bluuebunny/crossref_metadata_2025 huggingface dataset:
PROFIL HEMODINAMIK PASIEN PASCA INDUKSI ANESTESI UMUM DENGAN PROPOFOL DI RSUP PROF. DR. I.G.N.G NGOERAH
Authors: Astuti Ni Komang Ayu Widya , Kresna Sucandra I Made Agus , Parami Pontisomaya , Heryana Putra Kadek Agus
Published: December 2024

Saat ini, teknik anestesi yang paling sering digunakan pada prosedur pembedahan adalah anestesi umum. Tindakan anestesi umum diawali dengan melakukan induksi, dimana propofol menjadi salah satu obat induksi intravena yang paling sering digunakan. Namun, propofol diketahui memiliki efek mendepresi sistem kardiovaskular sehingga dapat mengubah stabilitas hemodinamik. Oleh karena itu, penelitian ini bertujuan untuk mengetahui profil hemodinamik pasien pasca induksi anestesi umum dengan propofol di RSUP Prof. Dr. I.G.N.G Ngoerah. Desain penelitian ini adalah deskriptif cross-sectional dengan sumber data sekunder dari rekam medis pasien bedah elektif tiroidektomi yang menjalani induksi anestesi umum dengan propofol di RSUP Prof. Dr. I.G.N.G Ngoerah periode Januari-Desember 2021. Subyek berjumlah 55 pasien yang memenuhi kriteria inklusi dan eksklusi yang kemudian dicatat parameter hemodinamiknya yang meliputi tekanan darah sistolik, diastolik, tekanan arteri rerata, dan laju nadi. Hasil yang didapatkan, terjadi penurunan tekanan darah sistolik pasca induksi sebesar 9,36%, penurunan tekanan darah diastolik sebesar 3,67%, penurunan tekanan arteri rerata sebesar 6,25%, serta penurunan laju nadi sebesar 4,06%. Melalui hasil tersebut, dapat disimpulkan bahwa terjadi perubahan hemodinamik pasca induksi anestesi umum dengan propofol yang meliputi penurunan tekanan darah sistolik, diastolik, tekanan arteri rerata, dan laju nadi.
Early Bronze Age of the steppe Urals and Western Kazakhstan: some results and research prospects
Authors:   The Bauman Moscow State Technical University, 2nd Baumanskaya str., 5, Moscow,105005, Russian Federation, Khavansky Alexey I. ,   National Research University “Moscow Energy Institute”, Krasnokazarmennaya str., 14, p. 1,   Lefortovo, 111250, Moscow, Russian Federation, Bisembaev Arman A. ,   Institute of Archaeology named after A.Kh. Margulan. Dostyk Ave., 44, Shevchenko Str. 28, Almaty, 050010, Republic of Kazakhstan; Associate Professor. Aktobe Regional University named after K. Zhubanov. Aliya Moldagulova Ave., 34, Aktobe, 030000, Republic of Kazakhstan
Published: December 2024

The article presents the history of the study and current state of the issues of the Early Bronze Age in Western Kazakhstan. This period in Western Kazakhstan is represented by monuments of the Yamnaya cultural-historical community. Before the beginning of the XXI century Yamnaya sites in Western Kazakhstan were represented by “classical” complexes, studied in the middle of the XX century on the river Ilek, the border of the Southern Ural and Western Kazakhstan. These are Tamar-Utkul VII and Tamar-Utkul VIII, Izobilnoye I and Izobilnoye II burial grounds, separate burials in the Mamai and Kresty burial grounds. Since the beginning of the XXI century, the unique Kumsay I burial ground has been studied in the south of the Aktobe region. It consists of 168 barrows. There are from 1 to 5 burials in each barrow. The burial pose is crouched on the back and sitting. The bones are covered with ocher, both completely and partially. A characteristic feature is the unstable orientation of the buried skeletons. Along with the orientation to the eastern sector, characteristic of the Yamnaya cultural and historical community, at least half of the buried are oriented to the northern sector with deviations. New materials make it possible to raise questions about the southern border of the Yamnaya cultural-historical community, migration routes and cultural contacts of the population of this community
Age-linked Groups in the Early Iron Age nomadic societies (preliminary results)
Authors:   Institute of History and Archaeology, Ural Branch of RAS, Berseneva Natalia A. ,   South-Ural State University. Lenina av., 78, Chelyabinsk, 454080, Russian Federation
Published: December 2024

Age-linked symbolism was often an important part of the burial ritual. The study aims to reconstruct age-linked social groups in the nomadic societies in the Southern Urals during the Early Iron Age (late 5th – 3rd centuries BC). The source base consisted of 23 published and partially published burial grounds and separate barrows of the Early Sarmatian period. The sample consisted of 183 individuals (141 females, 142 males) with gender and age (in years) identification. For analysis, only those burials were used where the individual belonging of the inventory did not cause doubts. Analysis of the sample showed that the age of the adult deceased (young, mature, elderly) was not determinant for the choice of weapons as accompaniments. There is a tendency for the amount of decoration to decrease with age аmong female burials. We can conclude that the peak of social activity lasted longer for men than for women. The correlation of age groups with other types of artifacts (cult objects, household items, horse harness or certain types of weapons/decorations), as well as with markers of high social status (prestigious things, labor-intensive structures) may be one of the further directions of research.
Horse in the Palaeometal era cultures of the Minusinsk basin
Authors:   Institute for the History of Material Culture of the Russian Academy of Sciences. Dvortsovaya Emb., 18, Saint Petersburg, 191186, Russian Federation, Poliakov Andrei V.
Published: December 2024

The article presents modern data on the stages of development of horse use by man in the Palaeometal epoch on the example of archaeological sites of the Minusinsk basin. The beginning was made in the Afanasievo era and can probably be considered as periodic domestication or early stages of domestication. In the Okunev culture, the first experiments in training and wider use of horses are already taking place. The Andronovo culture and the early stages of the Karasuk period demonstrate the use of the horse as a draft animal in light carts and chariots. Finally, the end of the Palaeometal epoch is characterized by horseback riding, which had a very significant impact on the entire economic life of steppe pastoralists.
The use of infrared thermography in the identification of surface temperatures in fast- and slow-growing broiler chickens
Authors: Karaarslan Solmaz , Nazlıgül Ahmet
Published: December 2024

This study aimed to identify through infrared thermal imaging technology the surface temperature of the eye, beak, head, trunk, leg, and body of fast- and slow-growing broiler chickens at 2, 4, and 6 weeks of age. A total of 140 1-day-old broiler chicks were used in the study. Two treatments were included: fast-growing (Ross 308) and slow-growing (Hubbard JA57), with two replicates for each treatment. Thirty-five broiler chickens were placed in each pen. Beak and leg surface temperatures were consistently higher in fast-growing broiler chickens during the 2nd, 4th, and 6th weeks. Except for the 4th week, the surface temperature differences in the eyes and other feathered areas between fast- and slow-growing broiler chickens were not statistically significant. Eye surface temperature was not influenced by age in either genotype. In both genotypes, the beak and head surface temperatures increased with age, while the body and trunk surface temperatures decreased. Additionally, leg surface temperatures increased with age in fast-growing broiler chickens. The litter surface temperature was consistently higher in pens housing the fast-growing genotypes across all measured weeks. As a result, age and genotype were determined to affect the surface temperatures of broiler chickens and litter. It is thought that using infrared cameras in poultry house systems can improve the welfare of broiler chickens.
Evli kadınların HPV farkındalığı ve endişe düzeyleri ile aşıya ilişkin tutum ve inançları arasındaki ilişki
Authors: Yıldırım Fatma , Alpaslan Arar Mevlüde , Yücesoy Hüsne , Şahin Ebru
Published: December 2024

OBJECTIVES: The aim of this study is to examine the relationship between HPV awareness, anxiety level, vaccination attitudes and beliefs of married women.
MATERIAL and METHODS: The study is descriptive and relationship-seeking, and 321 married women were included in the study. The research data were collected between May 07-August 20, 2024, and the Personal Information Form, Human Papillomavirus Awareness and Concern Scale (HPV-ACS), and Carolina HPV Vaccination Attitudes and Beliefs Scale (CHVABS) were used in the collection of data. Mean, standard deviation, simple linear regression and Pearson correlation analysis were used in the analysis of the data.
RESULT: The total HPV-ACS score average of women was 28.16±14.46, the total CHVABS score average was 28.21±8.64, and according to the correlation analysis, a statistically significant positive relationship was found between them (r=0.822, p<0.05). It was determined that age, income level, child status, pap smear test status, cervical cancer and menopause diagnosis were significant factors in explaining the HPV-ACS total score and were statistically significant (p<0.05). It was determined that age, income level, employment status, child status and pap smear test status were significant factors in explaining the dependent variable CHVABS total score and were statistically significant (p<0.05).
CONCLUSION: As the HPV awareness and concern level of married women increases, their attitudes and beliefs towards the HPV vaccine also increase.
Keywords: HPV, anxiety, vaccination, attitude, belief, nursing
Thermal Maturity of the Organic Matters and Kerogen Types in the Late Miocene Zeit Formation, Red Sea Basin, Eastern Sudan
Authors:   Omdurman Islamic University, Department Of Geology Faculty Of Science And Technology-Omdurman, Khartoum, Sudan
Published: December 2024

The pyrolysis data was used to determine the source rock quality and quantity as organic richness, source rock generating capability and kerogen types of the source rock in the Late Miocene Zeit Formation, Red Sea Basin, Eastern Sudan.
Transfer Learning-Based Real-Time Handgun Detection
Authors: Elmir Youssef , Abdelaziz Abdeldjalil , Haidas Mohammed
Published: December 2024

Traditional surveillance systems rely on human attention, limiting their effectiveness. This study employs convolutional neural networks and transfer learning to develop a real-time computer vision system for automatic handgun detection. A comprehensive analysis of online handgun detection methods is conducted, emphasizing reducing false positives and learning time. Transfer learning is demonstrated as an effective approach. Despite technical challenges, the proposed system achieves a precision rate of 84.74%, demonstrating promising performance comparable to related works, enabling faster learning and accurate automatic handgun detection for enhanced security. This research advances security measures by reducing human monitoring dependence, showcasing the potential of transfer learning-based approaches for efficient and reliable handgun detection.
Study the Physiological and Histological Effects of Moringa oleifera alcoholic Extract to Reduce the Harmful Effects of Red Lead Oxide in Male Albino Mice
Authors: Ghaidan Hajer Qais , Al-Dhamin Ahmed Saad Abdulwahhab
Published: December 2024

This study included investigating red lead oxide effects on the bodies of laboratory animals (Albino mice) and how to remove or reduce the effect of this pollutant that was dosed orally using the ethanolic extract of the Moringa oleifera (MO) plant. In the study, 40 adult male mice were used. At an average age of 8-10 weeks and with 21-29 grams average weight, the animals were randomly distributed among four groups with 10 mice/group. The first group M1 was the control group, the second group M2 was treated with red lead oxide only [1.25 mg/kg], while the third group M3 was treated with red lead oxide + Moringa oleifera [C1 = 8.4 mg/kg], and the last group M4 was treated with red lead oxide + Moringa oleifera [C2 = 9 mg/kg]. The results showed a significant difference increase in the growth rates of laboratory mice (p≤0.05) for all studied groups, while the results of animals exposed to red lead oxide and treated with MO extract and those exposed to red lead oxide only showed a significant difference increase (p≤0.01) compared to the control group. In addition, the results of the FBS analysis showed that there was a highly significant increased (p≤0.01) among the four groups that were mentioned earlier and when compared to the control group. The histological examination sections showed different changes in the tissues of the liver, pancreas and kidneys of the mice. The results of this study indicated that an extract of MO, is important to reduce the adverse effects of exposure to red lead oxide toxicity. The administration of MO returned some parameters to control, especially histological sections. It showed that red lead oxide had a harmful effect on tissue sections, while MO plant extract reduced the toxicity of red lead oxide for the M3 and M4 groups.
Taxifolin Attenuates Hepatic Fibrosis and Injury in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetes Mice
Authors: Thu Vu Thi , Kha Pham Trong , Yen Ngo Thi , Bich Pham Thi , Phuong Luu Thi Thu
Published: December 2024

This study investigated the protective effects of taxifolin (TAX), a bioflavonoid, against hepatic fibrosis and injury in the type 2 diabetes mellitus (T2DM) mouse model. T2DM model was induced in male C57BL/6 mice by high-fat diet (HFD) and intraperitoneal injection for 5 consecutive days of 40 mg/kg streptozotocin (STZ). HFD-STZ groups were administered TAX (80 mg/kg/day) or vehicle daily for 12 weeks. The control or wild-type (WT) group received equal amounts of the vehicle and was fed a normal chow diet. Body weight and blood glucose were checked every 4 weeks. H&E and Masson's trichrome staining were performed to assess liver fibrosis and injury. The western blot was used to determine the expression levels of key fibrotic proteins. The data showed that taxifolin treatment significantly decreased body weight, liver weight, and blood glucose in diabetic mice. In particular, liver enzymes including alanine transaminase (ALT) and aspartate transferase (AST), and triglyceride levels were significantly higher in the non-treated diabetic group than in the WT group but markedly reduced after TAX treatment. In addition, the histological analysis revealed that TAX attenuated hepatic interstitial fibrosis. Moreover, western blot data showed downregulation of fibrotic markers including TGF-β1, Col1a1, and Smad2 in TAX group treatment indicating the molecular mechanisms through which TAX exerts its hepatoprotective effects. These findings suggest that TAX holds therapeutic potential in mitigating liver fibrosis and injury associated with T2DM, providing a promising avenue for further research and potential clinical application.
Global Research Trends in Sustainability and Environmental Issues: A Sustainable Environment and Future Directions
Authors:   Departement of Public Administration, Faculty of Social and Political Sciences, Universitas, Padjadjaran, Indonesia, Buchari Rd. Ahmad , Muhtar Entang Adhy ,   Departement of Public Administration, Faculty of Social and Political Sciences, Universitas, Padjadjaran, Indonesia, Aiyub Kadaruddin ,   Faculty of Social Sciences and Humanities, University Kebangsaan Malaysia, Malaysia, Abdillah Abdillah ,   Center for Decentralization & Participatory Development Research, Faculty of Social and Political Sciences, Universitas Padjadjaran: Bandung, Indonesia, Miradhia Darto ,   Departement of Public Administration, Faculty of Social and Political Sciences, Universitas, Padjadjaran, Indonesia, Muharam Riki Satia ,   Departement of Public Administration, Faculty of Social and Political Sciences, Universitas, Padjadjaran, Indonesia
Published: December 2024

Global rapid economic growth is a cause of significant environmental issues threatening the welfare of current and future generations in the 21st century. The issues show the need for sustainable environmental development, which correlates with the importance of the Sustainable Development Goals (SDGs) program. Therefore, this research aimed to identify and examine global trends in sustainability and environmental issues, as published in Scopus-indexed journals from 1982 to 2022. Data on sustainability and environmental issues over the past 40 years were collected from the Scopus database. These included 1,324 English-language documents examined through bibliometric analysis performed with VOSviewer. The analysis explored the evolution of publications over time, categorized by classification, citations, subject areas, document types, authors, countries, institutions, journals, documents, and keywords. The results provided insights and discussions on sustainability and environment investigations, guiding future publications. This research would serve as a resource for scholars interested in collaborative projects in environmental sustainability, facilitating the exchange of ideas and results with academics, non-governmental organizations (NGOs), government agencies, and other stakeholders. The objective was to provide practical directions for advancing sustainability to ensure long-term social resilience and planetary health.
Modeling design of the hybrid energy resources considering technical and economic indices
Authors: P Allathadka H. , C Kumar O. , Raman Arasu , Chammam Abdeljelil , Al-Hedrewy Marwea , Kumar Abhinav , Kumar Mithun , Thakur Vishal , Priye Ati , Misra Neeti , Prasad KDV
Published: December 2024

This study is dedicated to exploring the optimal sizing and strategic placement of hybrid energy systems specifically tailored for the electronics laboratory at Manipur International University in India. The primary objective is to effectively integrate photovoltaic systems alongside energy storage solutions, ensuring that both economic and technical goals are met. These goals encompass minimizing the total net present cost, reducing the levelized cost of electricity, and decreasing the probability of power supply loss, which are critical factors in the design and implementation of sustainable energy systems. To achieve these objectives, the design and sizing of the hybrid energy systems will be meticulously optimized. The study will consider various configurations, including combinations of photovoltaic-battery systems and photovoltaic-fuel cell setups. Each configuration will be evaluated for its efficiency and effectiveness in meeting the energy demands of the laboratory while adhering to the established economic and technical criteria. A key component of this research is the development of an energy management strategy grounded in energy balance principles. This strategy will guide the operation of the hybrid systems, ensuring that energy generation and consumption are harmonized to maximize efficiency and reliability. By implementing this strategy, the study aims to create a robust framework for managing energy resources effectively. To validate the proposed configurations and strategies, three practical case studies will be conducted. These case studies will utilize metaheuristic optimization techniques, which are advanced computational methods designed to solve complex optimization problems. Through numerical simulations, the study will identify the ideal sizing and configuration of hybrid energy sources, providing valuable insights into the practical application of these systems in the context of the laboratory.
Yakut shamanic rite Ytyk dabatyy by S. A. Zverev in audiorecording of 1969: text, interpretation, semantics
Authors:   Arctic State Institute of Culture and Arts, Yakutsk, Russian Federation, Nikiforova V.S. , Romanova E.N. ,   Institute for Humanities Research and Indigenous Studies of the North, SB RAS, Yakutsk, Russian Federation
Published: December 2024

Sergei Zverev, known as Kyyl Uola (1900–1973), was a famous Yakut singer of the olonkho epic, fairy tales
and performer of shamanic rituals. As a child he participated in the rituals of his relative, a mighty shaman
named Lappaakhi. In 1969 the ethnomusicologist Eduard Alexeev recorded from S. Zverev the shamanic
ritual Ytyk dabatyy ‘Ascension of the sacred horse’ in studio at Moscow. This recording is contained on
a vinyl record by Melodiya (1971, D 030639-40). This article, written by an ethnomusicologist and
ethnographer, is devoted to a complex analysis of this audio recording. The methodological basis of the
article is the concept of the sounding landscape and semiotic analysis. The authors reconstruct the multilayered musical part of the shamanic ritual on the basis of ethnographic, folklore and mythological materials,
including archival sources, and also uncover the sacred biography of the singer. One of the important
conclusions of the article is the allocation in the Yakut ritual culture of a special, characteristic only for the
Vilyui region, tradition of shamanic rites addressed to heavenly deities with negative valence. In addition, the
work describes the form-generating role of melodic-rhythmic and timbre structure in a musical performance.
It creates space and draws the plot outline of the shaman's “journey” to the upper world and his return back.
The musical narrative of the rite has seven sections, differing in melodic, rhythmic and timbre composition.
The text is supported by musical transcriptions made by one of the authors of the article.
Poetics of Koryak-Nymylan personal songs: a case study of the works by Lydia Innokentievna Chechulina
Authors:   Institute of Philology of the SB RAS, Novosibirsk, Russia, Tiron E.L.
Published: December 2024

this study are the recordings of the musical works performed by Lidia Innokentievna Chechulina (Koryak name
Ӄyvnyutaӈav) taken at different times. These are fourteen songs, with one being sininkin ӄuliӄul (own personal
song) and the others paninatyn ӄuliӄul (ancestral songs). The repertoire of Lidia Innokentievna includes songs
from three generations of her family (grandfathers, parents, and siblings). The analysis explores the vocabulary
of personal songs, indicating a sacred view of this musical phenomenon within Koryak-Nymylan culture and
validating the accuracy of the song performance. The authenticity of the performed song is confirmed by the
verbs ivi (spoke) and direct speech constructions. Invocation of ancestors during song performance is conveyed by the verb myng’eŋavyn (to call). The frequent use of the phrase gyrap myntalivyn (we will roll the
melody downhill) is attributable to the transmission of ancestral songs from hilltop burial sites. Ancestors are
portrayed as a defined group, denoted by paninalu (ancestors) and ӄaytumguv’v’e (relatives), residents of
Koryak settlements (for example, Alutalu (residents of Olyutorka), and as the environment of a particular ancestor, with his name used in plural). Furthermore, the texts reveal the song performance context (tambourine
playing, dancing, exquisite traditional women’s attire, and exuberant spirits) alongside vivid auditory and
visual representations of the surrounding world of Kamchatka. Typical characteristics include the usage of
interjections, exclamations, reindeer herding vocalizations, chanted syllables and words, and onomatopoeia
imitating animal and bird sounds.
Ob-Ugric drum: morphology, organophony
Authors:   Institute of Philology, SB RAS, Novosibirsk, Russian Federation, Soldatova G.E.
Published: December 2024

The article is devoted to ethnomusicological consideration of the shamanic drum of Khanty and Mansi (ObUgric peoples). The study is based on the publications of ethnographers, open access video and field materials of the author. An important role in the work is given to special folk terminology related to the structure of
the instrument and its name.The author found that the Ob-Ugrians’ drum is a composite musical instrument,
its components are simple sound instruments: membranophone and several types of idiophones (rattles). The
handle and hammer are often called “spoon” and “arrow” or otherwise, but these names are not strictly assigned to them; they may have been interchangeable in the past. Three factors influencing the sound potential
of the instrument have been identified: morphological (two resonator cavities and many pendants), physical
(wood material, membrane temperature) and performance (the position of the drum and the shaman when
playing).In many shamanic rituals of the Ob-Ugric peoples, other instruments were also played: the zither (on
which personal melodies of the spirits were played) and the board with arrows (for transmitting “messages”
from the spirits to the participants of the ritual). The zither and the board with arrows could completely replace the drum in the ritual. The author suggests that the Ob-Ugric drum is an instrument of late origin, and
the use of the drum, zither and the board with arrows in the ritual culture of Khanty and Mansi has different
historical, geographical and ethnic roots.
Hunting and fishing vocabulary of Telengits and Chalkans based on 2024 field research
Authors:   Institute of Philology of the Siberian Branch RAS, Novosibirsk, Russian Federation, Shagdurova O.Yu. , Tyuntesheva E.V. , Fedina N.N. , Plotnikov I.M.
Published: December 2024

This paper outlines the initial findings from the 2024 expedition to the speakers of two South Siberian Turkic
languages: Chalkan and the Telengit dialect of Altai. The expedition, conducted within the Ulagansky and
Turochaksky districts of the Altai Republic, focused primarily on documenting the vocabulary associated
with hunting and fishing, traditional livelihoods of the local inhabitants. Interviews were conducted with informants representing a range of generations, with birth years from 1948 to 1996. The collected data included
over 200 lexical units and 620 minutes of audio materials comprising stories recounted by hunters and fishermen. The analysis revealed a gradual decline in the use of specific vocabulary, evidenced by the simultaneous use of native and Russian words, the presence of code-mixing in the speech of younger individuals, and
the limited use of euphemisms, mainly restricted to the denominations of bear and wolf. The vocabulary reflects the preservation of diverse decoy and whistle types, crafted using both traditional methods and contemporary materials, and the adaptation of commercially procured whistles for this use. Observations revealed that the Chalkans possessed a more extensive lexicon encompassing the terminology of fishing techniques, tools, and culinary preparations involving fish. The materials collected contained vocabulary exhibiting general Turkic and Siberian regional linguistic elements, a trait observed in specific languages examined
in the study. Notably, Telengit exhibits dialectal vocabulary that differentiates it from the standard literary
Altai language, establishing a linguistic connection with other Siberian Turkic languages.
Unveiling the mysteries of language: a tribute to Maya Ivanovna Cheremisina
Authors:   Institute of Philology of the Siberian Branch RAS, Novosibirsk, Russian Federation, Shamina L.A.
Published: December 2024

A significant milestone for the scientific community was reached on September 30, 2024, marking the one
hundredth anniversary of the birth of the distinguished Russian scientist, Doctor of Philology, Professor Maya Ivanovna Cheremisina. This article pays tribute to the memories and experiences shared by the author during the collaborative work, conferences, expeditions, and even ordinary events with Maya Ivanovna. Of particular note in the article is the proactive role of Maya Ivanovna in conducting a series of expeditions
throughout Siberia and the Far East. These expeditions, under her expert guidance, yielded invaluable insights and information. As a result, numerous collections and monographs were published, both collective and authored, shedding light on the current state of the Altai languages in Siberia. Furthermore, the article
acknowledges the contributions made by Maya Ivanovna and her students in developing the field of linguistics. Specifically, it mentions the work of E. I. Ubryatova, who asserted that Turkic languages utilize similar
linguistic methods to establish connections between words and higher language units like phrases and sentences. Building upon this idea, Maya Ivanovna and her students expanded and refined the concept in their
subsequent works. To enhance the understanding and appreciation of these remarkable achievements, the article provides a collection of photographs capturing moments from the field research, conferences, and other
related events. This article commemorates the centennial of the birth of Maya Ivanovna, summarizing her
impactful career and significant contributions to linguistics and scientific exploration.
Professor M. I. Cheremisina and sociolinguistic study of the languages of indigenous peoples of Siberia
Authors:   Katanov Khakass State University, Abakan, Russian Federation, Kaksin A.D.
Published: December 2024

Maya Ivanovna Cheremisina, a distinguished Russian linguist, Doctor of Philology, Honored Scientist of the
Russian Federation, and founder of the Novosibirsk Syntactic School, is recognized for her significant contribution to the development of traditional sociolinguistics. This paper sheds light on her significant contributions. It elucidates the ideas that the scholar advocated regarding the societal development of indigenous Siberian languages. Emphasis is placed on the organizational role of Maya Ivanovna Cheremisina in the deployment of linguistic works at the Novosibirsk Scientific Center, particularly in relation to the sociolinguistic analysis of indigenous peoples of Siberia. These works are a part of the overall research agenda of Maya
Ivanovna Cheremisina, her colleagues, and students in the field of general and typological linguistics.
Сomparative constructions in the Ket language
Authors:   Tomsk State Pedagogical University, Tomsk, Russian Federation, Kryukova E.A.
Published: December 2024

Comparative constructions have not yet been the focus of a dedicated study. Separate grammars, dissertations, and articles by ketologists have explored the concept of degrees of comparison in relation to adjectives.
This article describes comparative constructions in the Ket language by analysing a corpus comprising 8032
words of Ket folklore and daily prose texts, encompassing 1293 sentences across 38 texts. These are primarily texts in the Kureyka dialect (North Ket dialect), with an additional five texts representing the Yeloguy dialect (South Ket dialect). All materials were collected by A. P. Dulzon during expeditions conducted in 1956,
1959, and 1960. The corpus primarily includes texts published in a glossed form in the collection series “Annotated Folklore and Daily Prose Texts of the Ob-Yenisseic Linguistics Area.” Also coverec in the corpus are
Ket riddles published by E. A. Kreinovich in the “Studia Ketica”. The study has found only 9 sentences with comparative constructions, with the relations under analysis expressed explicitly by means of the conjunctions eta / qoda / eta qoda (as, as if), the postpositions as (as), dokot (as), the adverb bila (as), and the ablative case affix -daŋal / -diŋal. This does not preclude the existence of widespread comparative relations in the
Ket language. The nature of language permits the implicit expression of ideas, based on the context of the
situation, a characteristic likely found in non-written languages. Nonetheless, locating such instances within
the corpus using search managers has proved infeasible. Manual searches for these situations are consequently quite arduous.
Symptoms extraction and automatic diagnosis prediction from medical clinical records.
Authors: Сердюк Юрий Петрович
Published: December 2024

В статье представлена система, которая извлекает симптомы заболеваний
из медицинских клинических записей (текстов на естественном русском
языке) и автоматически предсказывает по ним диагноз в виде наименования
заболевания и его кода в соответствии со справочником МКБ-10. Система
ограничена предметной областью из 6 пульмонологических заболеваний
(хроническая обструктивная болезнь легких, пневмония, бронхиальная астма
и др.) и COVID-19.

Извлечение симптомов реализовано с помощью нескольких нейронных
сетей, выделяющих отдельные медицинские сущности и связи между ними.
Предсказание диагноза также реализовано в виде классификатора на основе
нейронной сети. Для обучения извлечению симптомов создан аннотированный
корпус предложений. Описаны принципы и правила разметки симптомов.
Представлен корпус текстов для обучения классификатора предсказанию
диагнозов.

Приведены оценки точности при тестировании обеих подсистем. Точность
предсказания диагноза на данной предметной области составила 88,5%. Даны
сравнения с аналогичными работами по извлечению симптомов из текстов на
различных языках, а также по автоматическому предсказанию диагнозов,
включая системы типа ChatGPT.
Menyelami Lautan Tafsir: Epistemologi dan Pendekatan Syi’ah dalam Memahami Al-Qur’an
Authors: Niam Mohammad
Published: December 2024

This article discusses Shia School of Tafsir, including methods of interpretation, prominent figures and their works, and Shia interpretations. The research adopts a qualitative approach, which relies on theoretical investigation. The type of research can be classified as library research, where data is sourced from published written materials, both in print and electronic media, relevant to the research topic. Through this approach, the research finds that Shia Tafsir is a discipline initiated by Shia adherents and followers to explore the knowledge, guidance, meanings, laws, and wisdom of the Book of Allah based on human capabilities. Advocates: Ali bin Thalib. The method used by the Shia Ismaili group is takwil, emphasizing the concept of esoteric and exoteric meanings, although they claim that only the esoteric meaning intended by the verses. The Itsna Asyariyah group also employs takwil method in interpretation, always striving to align Quranic verses with their doctrines. Meanwhile, Shia Zaidiyah tends to use a more moderate method in interpreting the Quran, closer to Ahlusunnah methods. Among Shia, both classical and contemporary, numerous tafsir works have emerged, reflecting diverse approaches and perspectives within the Shia school of thought.
Musibah Perspektif Al-Qur’an
Authors: Dini Dini Mardina , Edomi Saputra  , Ika Ariyati
Published: December 2024

Disaster can strike whenever and wherever you are. He doesn't care whether the person is ready or not to face it. What is clear is that when he comes, people can only say Innalillahi wa inna dewa diligent. It is interesting to observe what exactly the disaster was. Is disaster a form of God's punishment for His sinful servants? Even if it were true, why did God create hell for those who sin? Because isn't that the answer? Apart from that, what is no less important is that it is often found that believers do not escape disaster. Is a disaster a 'punishment' from God? And also various other questions. This study uses a qualitative method. This research contributes to the development of insight in the field of interpretation. The research results show that there are many verses in the Qur'an regarding disaster which not only mean bad things but also include good ones. Disasters do not only befall those who disbelieve, but also those who believe. In fact, the Qur'an warns to be careful of the torment that not only befalls those who do wrong, but also affects everyone around them (Qs al-Anfal [8]: 33).
Keywords: Disaster, Al-Qur'an.
Process Validation of Dispersible Tablet Comprising of Tenofovir, Bictegravir and Emtricitabine
Authors: N Mehetre , I Singh
Published: December 2024

In the formulation of Orodispersible tablets, process parameters were checked to ensure consistent tablet quality, including factors like uniformity in size, shape, and coating. Monitoring these parameters helps optimize disintegration, dissolution, and hardness, ensuring the tablet meets its intended release profile and complies with regulatory standards. In this research, process validation for drying time, prelubrication time, lubrication time, hardness and % weight gain parameters were checked. Drying time was set as 20 min, 25 min and 30 min, Prelubrication time was set as 8 min, 10 min and 12 min and lubrication time was set as 1 min, 3 min and 5 min. Evaluation was done for the optimum selection of these parameters which affects the dissolution, disintegration, assay and LOD. In this research, three validation batches were taken amongst batch F2 showed the results in acceptable range. Disintegration time for the batch F2 was found in acceptable range i.e 1min 23 sec. % weight check was determined during coating of the tablets and it was found is acceptable range. Optimum hardness was selected which was15 to 17 kp, For F2 it was found to be16.56±0.6 The dissolution for the batches observed in the acceptable ranges amongst F2 showed maximum release it may be due to optimum selection of the hardness, % weight gain lubrication time and prelubrication time. F2 batch was found to be stable for 3 months at accelerated condition and long-term conditions.
Nanomedicine in Cancer Treatment: Harnessing Nanotechnology for Targeted Drug Delivery and Advanced Imaging Techniques
Authors: S Amin S , D Jogdand S
Published: December 2024

Nanomedicine has transformed cancer treatment by utilizing nanotechnology to create more precise, targeted, and less toxic therapies. Traditional methods like chemotherapy and radiation often lack specificity, causing side effects and limiting effectiveness. Nanoparticles, sized between 1 and 100 nanometres, enable targeted drug delivery, minimizing damage to healthy tissues. Through the improved Permeability along with Retention (EPR) effect, nanoparticles accumulate in tumours due to leaking vasculature. Active targeting, using ligands like antibodies, enhances precision by interacting with specific cancer receptors, such as HER2 in breast cancer. Doxil is a liposomal preparation of doxorubicin that improves progression-free survival in ovarian cancer patients by reducing cardiotoxicity. Nanoparticles also enhance cancer imaging, improving the resolution of techniques like MRI, CT, and PET. Gold nanoparticles and iron oxide nanoparticles act as contrast agents, aiding early tumor detection. Furthermore, Theranostic nanoparticles integrate therapeutic and diagnostic functions, facilitating real-time assessment of treatment efficacy for enhanced tailored care. Despite its potential, Nanomedicine faces challenges like toxicity, immune clearance, and scalability. Nanoparticles may be identified and eliminated via the reticuloendothelial system (RES), reducing efficacy. However, solutions like PEGylation and biodegradable nanoparticles are addressing these barriers. The global Nanomedicine marketplace, valued at $150 billion in 2021, is anticipated to expand at a compound annual growth rate (CAGR) of 11.9% complete 2030, underscoring the expanding role of nanotechnology in cancer treatment.
Vitamin D as an Adjuvant Therapy for Eradication of H. pylori. A Randomized Controlled Clinical Trial
Authors: Awad Yosra Mohamed Mohsen , Hamdy Ahmed Mohamed , Bebars Gihan Mohamed , Yasin Shaimaa Mohamed , Hanna Chrestina Monir Fekry , Mounir Samir M
Published: December 2024

Background: Helicobacter pylori shows high rate of antibiotic resistance and declining eradication rates; thus, a salvage
therapy is needed. Vitamin D is known to have antimicrobial and immune modulatory properties. Observational studies
linking Vitamin D serum levels to H pylori eradication have paved a way for interventional clinical trials. Aim: To study
the effect of adding Vitamin D to the standard clarithromycin based triple therapy on eradication rates of H pylori.
Subsidiary aim was to detect vitamin D serum levels among Egyptian Children infected with H pylori. Methods: A
randomized controlled clinical trial including 200 children with an age range between 5-15 years, presenting to pediatric
gastrointestinal endoscopy, and diagnosed as having H pylori infection based on histopathology of their gastric biopsy
specimens, they were randomly allocated to 2 groups, one group received the standard clarithromycin based triple therapy,
while the other group received 1000 IU Vitamin D 3 in addition to the triple therapy. Fecal antigen was done 1 month after
stopping the medications to diagnose success of eradication. Results: The eradication rate of H pylori was significantly
higher (82 %) among the group receiving Vitamin D supplementation , in comparison to the other group (51%). Also,
Vitamin D intake was an independent factor for predicting the success of eradication (odds ratio: 5.08, CI: 2.51-10.98, P
value=0.0001). Conclusion: Vitamin D supplementation improves eradication rates of H pylori among children especially
at communities with prevalent Vitamin D deficiency.
Assessment of Clinical Pharmacist-Initiated Optimisation of Pharmacotherapy in Patients with Acute Coronary Syndrome
Authors: T S Abdul Haseeb , Abushoumi Fatimah , Dobayan Zakariya Al , Al-Ghamdi Fuad
Published: December 2024

This comprehensive study of the effect of clinical pharmacist-initiated optimisation of pharmacotherapy in patient role
with acute coronary syndrome. In this context, the authors conducted a open-label, randomized regulated testing in which
324 patient role with ACS were admitted to five tertiary care centres from January 2022 to March 2024. The primary
objectives set were assessing the effect of clinical pharmacist involvements on medication safety and guideline
adherence, leading to better clinical outcomes. The presented results were significantly reduced medication errors,
guideline adherent prescribing, and a minimised 30-day rate of major adverse cardiovascular events (MACE). This study
supports clinical pharmacists' integral role in optimising pharmacotherapy for patients with ACS and provides evidence
of long-term benefits in cardiovascular care15.
Effect of adding SGLT2 Inhibitors and Site of Right Ventricular (RV) Pacing on Left Ventricular (LV) Dyssynchrony, Contraction Efficiency and RV Function
Authors: Setouhi Amr , Taha Nasser , Ali Mustafa M. , Eldin M Hossam , MD Mahmoud
Published: December 2024

SGLT2 inhibitors have become cornerstones in the treatment of HF across the spectrum of ejection fractions, with
several trials such as EMPEROR-Preserved and DELIVER showing these drugs to decrease all-cause mortality and
hospitalizations. Whereas the favorable effects of SGLT2i on left ventricular function are well established, those of
SGLT2i on right ventricular function remain relatively unexplored. This review shall investigate the importance of RV
function in HF, particularly about the positioning of the pacemaker lead and its impact on cardiac output. It was
underlined that the most important function of advanced echocardiographic techniques, such as three-dimensional
echocardiography and speckle-tracking imaging, provided an opportunity for more valid RV systolic function compared
to traditional measures such as TAPSE. This includes the following: SGLT2i probably may improve RV function due to
the drug's effect of reduction in pulmonary arterial stiffness, hemodynamic profile improvement, and favorable metabolic
shift in myocardial energy utilization. Several emerging pieces of evidence suggest that, beyond the reductions in
hospitalization, SGLT2i is associated with significant improvements in RV systolic function, as evidenced by improved
parameters such as RV fractional area change and longitudinal strain. Further mechanistic studies, focusing on the action
of SGLT2i on RV function, should be emphasized, including anti-inflammatory effects and vascular compliance. In
brief, the incorporation of SGLT2i in heart failure management may exert an optimum effect on both LV and RV
functions with a strong emphasis on overall cardiac evaluation. This work will also require extended comprehension of
RV dynamics in the clinical field toward better improvement in the outcomes among patients suffering from heart failure
through targeted therapies.
Giant Ulcerating Pilomatricoma: A Case Report
Authors: Sangam Vimal Bheemsain , Patel Nikita M. , Shah Hiral A. , Chauhan Jatin
Published: December 2024

Pilomatricoma is a rare benign adnexal neoplasm originating from hair follicle matrix cells in which giant, bullous, ulcerating, anetodermic and lymphangiectatic variants may be seen. Giant pilomatricomas (size > 5 cm) rarely ulcerate, and are often a diagnostic challenge as they resemble cutaneous malignancies. We report the case of a 45-year-old male who presented with a slow-growing, ulcerating nodule on the left forearm.
Obesogenic diet-induced insulin-resistant rats develop neurobehavioral and memory deficits following bisphenol-A and cadmium co-exposure
Authors: Lawal Abdulwasiu Taiwo , Akinola Oluwole Busayo
Published: December 2024

Objectives

Obesogenic high-fat diets (HFD) have been widely implicated in the etiology of dementia-related neuropathologies through the disruption of brain insulin signaling. Likewise, exposure to environmental toxicants has been associated with various neurodegenerative symptoms attributed to their oxidative stress-mediated neurotoxicity. Thus, this study aims to investigate the effects of exposure to the environmental toxicants, bisphenol-A (BPA) and cadmium (Cd), on the exploratory instinct and spatial awareness memory of HFD-induced insulin-resistant adult Wistar rats.

Material and Methods

Twenty-five adult Wistar rats were randomly assigned to five groups (A–E; n = 5) and treated as follows: A: normal saline; B: 40 mg/kg.bw CdCl2+HFD+Suc; C: 40 mg/kg.bw BPA+HFD+Suc; D: 40 mg/kg.bw BPA+ 40 mg/kg.bw CdCl2+HFD+Suc; E: HFD+Suc, orally for 56 days. Rats were subjected to the Y-maze behavioral test for spatial awareness and learning memory, and the respective trials were recorded as measures of short-term memory and spatial awareness. On the last day of the experiment, brains were excised, the hippocampus was dissected from each group, and samples were processed for H&E histological investigation.

Results

Results from this study revealed that BPA and Cd impaired exploratory instincts and spatial awareness of insulin-resistant rats by significantly reducing their exploration of the Y-maze. The hippocampus of exposed rats also revealed neurodegenerative-like changes in histoarchitectural studies with extensive nuclear condensation.

Conclusion

Histomorphological and behavioral evidence from this study suggests that exposure to oxidative stress-inducing and insulin-signaling perturbing chemicals cause deficits in cognitive and short-term memory.
A Hydrogeochemistry Analysis for Quality Determination of Shallow Karstic Groundwater in Western Tuban, Indonesia
Authors: Pambudi Setia , Sulistijo Budi , Iskandar Irwan , Yudiantoro Dwi Fitri , Haty Intan Paramita , Ekasara Adam Raka , Afrilita  , Yoni Dian Rahma , Pratomo Septyo Uji
Published: December 2024

Groundwater hydrogeochemistry and water quality assessment have been conducted in western Tuban, Indonesia, which is characterized by its karstic features based on physicochemical parameters (pH, electric conductivity, total dissolved solids, hardness, Ca2+, Mg2+, Fe3+, Mn2+, K+, Na+, Li+, NH4+, HCO3-, Cl-, SO42-, NO2-, and NO3-) from 25 shallow groundwater samples. The Piper diagram implies the groundwater is of HCO3–Ca+Mg type with some Na+K–SO4+Cl type meaning that the groundwater in Western Tuban is influenced by the silicate minerals weathering, the dissolution of carbonate lithology, and seawater intrusion. Durov diagram shows that the evolution of groundwater is influenced by ion exchange with clay minerals and by mixing with seawater. The Gibbs diagram indicates that the change in the chemistry and quality of groundwater is caused by a dominance of rock-water interaction in the Western Tuban. The water quality assessment based on the USSL and Wilcox diagrams indicates a high level of salinity and relatively low sodium, meaning that the suggested crops should have good salt tolerance, and the cultivated soil should still be able to handle the relatively low sodium level for irrigation.