bluuebunny/crossref_metadata_2025 huggingface dataset:
ДИДАКТИЧНИЙ АСПЕКТ ФОРМУВАННЯ ЦИФРОВОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ ФАХІВЦІВ-ЕКОНОМІСТІВ ПРИ ВИКЛАДАННІ КУРСУ «МОДЕЛЮВАННЯ БІЗНЕС-ПРОЦЕСІВ»
Authors: Добровольська Наталія , Мерінова Світлана , Добровольський Олександр
Published: April 2023

У статті порушено проблему формування цифрової компетентності майбутніх фахівців-економістів. Зазначено, що під цифровою компетентністю розумітимемо здатність адекватно використовувати цифрові технології для виконання професійних завдань та управлінськоїдіяльності. При цьому складовими цифрової компетентності майбутніх фахівців з економіки, нанашу думку, можуть бути визначені наступні: вміле використання цифрових технологій, цифровабезпека, цифрова комунікація, цифрова грамотність. Сучасний економіст не може здійснюватипрофесійну діяльність без використання сучасних цифрових інструментів. Зрозуміло, щодіджиталізація суспільства передбачає вдосконалення професійної підготовки майбутніхекономістів в умовах інформаційного освітнього середовища закладу вищої освіти.У статті розглянуто саме дидактичний аспект формування цифрової компетентності майбутньогоекономіста. Дидактичні принципи визначено як систему основних вимог, якими слід керуватисяпри визначенні методів та форм навчання, які найбільше сприятимуть формуванню цифровоїкомпетентності майбутніх фахівців економістів, що навчаються за освітньою програмою«Економічна кібернетика» у процесі викладання дисципліни «Моделювання бізнес-процесів».Ураховуючи дослідження вітчизняних та зарубіжних науковців, зазначено, що загальноприйнятими дидактичними принципами навчання є такі принципи: принцип зв ́язку теорії зпрактикою науковості; cистематичності та послідовності; активності та самостійності; науковості;наочності; доступності навчання; емоційності навчання, контролю і корекції знань. Метою даноїстатті є виокремлення дидактичних принципів у контексті формування цифрової компетентностімайбутніх фахівців-економістів та розкриття їх шляхів реалізації під час викладання дисципліни«Моделювання бізнес-процесів».У Вінницькому торговельно-економічному інституті ДТЕУ готують фахівців спеціальності 051«Економіка» за освітніми програмами «Економічна кібернетика», «Міжнародна економіка»,«Економіка бізнесу». Проте, лише в освітній програмі «Економічна кібернетика» зазначено якобов’язкову компоненту дисципліну «Моделювання бізнес-процесів». Саме на прикладівикладання зазначеної дисципліни, виокремлені дидактичні принципи детально описані разомметодами та шляхами їх реалізації. Перспективи подальших досліджень вбачаємо у виокремленніорганізаційно-педагогічних умов та специфічних принципів формування цифрової компетентностістудентів майбутніх економістів.
ЕКСПЕРИМЕНТАЛЬНА ПЕРЕВІРКА ЕФЕКТИВНОСТІ ПЕДАГОГІЧНИХ УМОВ ФОРМУВАННЯ ЕКОЛОГІЧНОЇ КУЛЬТУРИ СТУДЕНТІВ ТЕХНІЧНОГО КОЛЕДЖУ
Authors: Коваль Юлія
Published: April 2023

У статті описано педагогічний експеримент й аналіз його результатів щодоефективності педагогічних умов формування екологічної культури студентів в освітньомусередовищі технічного коледжу. Констатувальний етап експерименту проводиться з метоювиявлення поточного стану освітнього процесу або певного педагогічного явища та стану йогоструктурних елементів, які були визначені до експерименту і не змінювались. Цей етапексперименту включає низку спеціальних дослідницьких методів: вивчення й аналіз педагогічноїдокументації, передового педагогічного досвіду та незалежних характеристик; анкетування;бесіди; інтерв’ю; тести. За одержаними результатами робляться загальні висновки про стандосліджуваної проблеми на цьому етапі наукового пошуку. Запитання носили в основномупроєктний характер, студенти могли моделювати ситуацію та власні дії в ній. Педагогічнідослідження проведені на констатувальному етапі експерименту, показали, що вихідні рівнісформованості екологічної культури студентів в експериментальній і контрольній групахорієнтовно однаково низькі за всіма компонентами екологічної культури. На формувальному етапіексперименту відбувалося вимірювання рівня сформованості екологічної культури студентівстосовно виокремлених критеріїв: мотиваційно-ціннісного, когнітивного, емоційно-вольового,дієво-практичного, рефлексивно-оцінного. Аналіз результатів педагогічного експериментуконстатував, що застосовування в навчанні запропонованих педагогічних умов позитивновідбивається на формуванні екологічної культури. В експериментальній групі виявилосязбільшення кількості студентів із високим і середнім рівнями сформованості екологічної культуриздобувачів технічної освіти, що стверджує висунуту гіпотезу.Результати формувального етапу педагогічного експерименту підтвердили, що обґрунтовані івпроваджені в навчання педагогічні умови було схарактеризовано та випробувано їхрезультативність на формування екологічної культури студентів в освітньому середовищітехнічного коледжу.
НОВІ ПІДХОДИ У МЕТОДИЦІ ВИКЛАДАННЯ МАТЕМАТИЧНИХ КУРСІВ ЗА ВИБОРОМ В ШКОЛІ
Authors: Падалко Ніна
Published: April 2023

У статті представлена методика формування знань учнів у процесі викладання курсу за вибором «Економічні задачі лінійного пpoгpaмування» з використанням інформаційно-комунікаційних технологій. Мета статті - показати ефективність вивчення запропонованого курсу за допомогою системи динамічної математики GeоGebrа. На думку авторів, введення прикладнихзадач із економічним змістом у шкільному курсі математики та пошук шляхів їх розв’язання,знайомить учнів з такими важливими категоріями, як податки, банківські розрахунки, доходи,витрати, прибуток тощо. Доцільність вивчення задач лінійного пpoгpaмування в школі за участіiнфopмaційно-комунікаційних технологій, обумовлена набуттям учнями умінь обґрунтовуватиекономічний зміст понять, величин і процесів, моделюючи їх у вигляді рівнянь, нерівностей та їхсистем. Доведено, що розроблений курс за вибором для учнів 11 класів формує компетентностіаналізу різних способів та методів знаходження розв’язку економічних задач. Учні, на прикладітипових зaдaч, мають можливість порівнювати одержані результати: їх стандартність чиоригінальність, затрачені обсяги обчислювальної роботи, практичну цінність.Даний курс дає можливість вчителеві математики показати учням всі допустимі методизнаходження розв’язку прикладних задач, зокрема, аналітичні, геометричні підходи та способи іззастосуванням спеціалізованих комп’ютерних пpoгpaм.Використання системи динамічної математики GeоGebrа у навчальному процесі дозволяєприскорити, полегшити, зробити наочними обчислення та побудови. Це дає можливість варіювати змінними, для усвідомлення змістового зв'язку між ними. Крім того, застосування програми даєможливість не лише впорядкувати евристичний пошук, але й звільнити час для здійсненнядодаткових самостійних досліджень. Використання інформаційно-комунікаційних технологій восвітньому процесі підкреслює практичну значимість математики та потребу у її вивченні.
ВИКОРИСТАННЯ ІНШОМОВНОЇ РОЛЬОВОЇ ГРИ ЯК МЕТОДУ ФОРМУВАННЯ ЕМОЦІЙНОГО ІНТЕЛЕКТУ МАЙБУТНІХ ФАХІВЦІВ З ЕКОНОМІКИ
Authors: Галашова Олена
Published: April 2023

У статті розглянуто необхідність формування емоційного інтелекту як однієї зпровідних особистісних та професійних властивостей майбутніх фахівців з економіки. Проведеноаналіз вітчизняних та зарубіжних досліджень феномену емоційного інтелекту, на базі якоговизначено доцільність використання іншомовної рольової гри для формування емоційногоінтелекту студентів економічних спеціальностей. Значна увага приділяється проблемі впливуемоцій на налагодження ділових стосунків та досягнення взаємовигідних цілей. Рольову грурозглянуто як насичену розмаїттям емоцій діяльність, під час якої виникає спонтанний зворотнийзв’язок між співрозмовниками. Пізнання самих себе, ситуації навколо себе, власних почуттів іемоцій та емоцій партнерів зі спілкування призводить до усвідомлення значимості контролю такоригування емоцій для досягнення взаєморозуміння. Особистий досвід автора свідчить, що зметою формування емпатії та емоційного інтелекту студентів, рольова гра має включати елементнепередбаченості. Ситуація виклику та непередбаченості виявляє здатність інтерпретуватизначення емоцій, аналізувати причини їх виникнення, впоратися з проявом негативних емоцій увербальній та невербальній комунікації. Коригування емоцій відбувається як результатпоглибленого самопізнання, виникнення емпатії у процесі навчального співробітництва йпартнерства. Визначена автором роль викладача у підготовці студентів до вільного обмінудумками, використання іншомовних комунікативних кліше та професійної лексики у процесіпроведення рольової гри передбачає цілеспрямоване поєднання виховних та навчальних методівдля формування емоційного інтелекту як важливої професійної компетенції майбутніх фахівцівекономічної сфери діяльності.
Impact of Insomnia on Anxiety and Depression among Post Stroke Patients
Authors: Kavipriya M  , Kulkarni Hiranyamayi , Solomon Hilda , Swaminathan Jayanthi , Rani A Anitha
Published: April 2023

Introduction: Insomnia is prevalent but unappreciated condition follows a stroke that can hamper recovery. The impact of insomnia on post stroke patient’s anxiety and depression remains unclear. Aim/Objectives: The study aimed to evaluate the association between the Insomnia with Anxiety and Depression among post stroke patients. Methodology: A cross sectional, observational, study was conducted among post stroke patients, aged above 30years. Of 200 responses, 191 responses who were willing to participate in the study were included. The survey instrument used were Hospital Anxiety Depression Scale (HADS) and Insomnia Severity Index (ISI) to access the anxiety, depression and quality of sleep among post stoke patients. Results: Majority of the study participants were males (59.2 %). In the present study, 34% of the participants were under the age group of 50 – 60. Based on Insomnia Severity Index majority of the responders had moderate insomnia (57%). Majority of study population had abnormal (71.20%) level of Anxiety and borderline (41.36%) depression level. There was significant association of severity of ISI with severity of Anxiety (p-0.030) and depression (p-0.049) among post stroke patients. Conclusion: Stroke leads to significant reduction in quality of life. Reduction in daily activity results in worsening of function and disturbance in sleep, leads to depression that affects the physical and mental health. Post stroke patients with the symptoms of insomnia are at the risk of developing anxiety and depression.
GREEN SYNTHESIS AND CHARACTERIZATION OF CODOPED ZnO NANOPARTICLES VIA THE ACCUMULATION OF COBALT ION ONTO PISTIA (Pistia stratiotes L.,) PLANT TISSUE AND ITS PHOTOCATALYTIC ACTIVITY TOWARD ORGANOSULFUR POLLUTANTS
Authors: Rani N. Usha , P. Pavani  , Sesha Sai Pavan Kumar Chebolu Naga , Singh Marok Satwinder , Tulasi S. L.
Published: April 2023

Water pollution has recently become a serious global problem and hence researchers were focusing to develop innovative methods for the purification of water and then getting access to purified water by reducing pollution. As a result, the current study concentrated on synthesizing cobalt-doped zinc oxide nanoparticles by accumulating cobalt ions on Pistia (Pistiastratiotes L.) plant tissue and combining them with zinc acetate precursor. Further, the synthesized particles were analyzed for their efficiency in photo-desulphurization of organo sulphur compounds such as Dibenzothiophene and 2,5-dimethyl thiophene. Various characterization studies proved that the nanoparticles were oval in shape and had particle sizes of 8-34 nm and the particles were distributed with less aggregation. The particles have 47 % of zinc element and 21% cobalt with hexagonal (wurtzite) crystalline structure. The synthesized Co-doped ZnO nanoparticles were utilized for the desulfurization of Sulphur containing pollutants such as dibenzothiophene and 2,5-dimethyl thiophene. The results proved that rapid desulfurization was observed during the initial time of the study. The % desulfurization of 14.36±0.136 and 19.63±0.201% was observed within 5 min of the study for dibenzothiophene and 2,5-dimethyl thiophene. Whereas the high % desulfurization was noticed within less time of 25 min wherein the % desulfurization was observed to be 95.61±0.279 and 93.66±0.137 for dibenzothiophene and 2,5-dimethyl thiophene respectively. The removal of harmful heavy metals utilizing the Pistia plant and recycling in the wastewater treatment process may therefore be inferred as being highly valued. Additionally, the Co-doped ZnO photocatalysts might improve photocatalytic activity owing to the catalysts' porosity and the hole recombination and electron suppression.
EXPERIMENTAL SCRUTINIZATION ON THE TREATMENT OF SYNTHETIC WASTEWATER USING NEEM BARK AND DATE PALM FIBER AS AN ADSORBENT
Authors: A. M Saravanan , Hashmi Raiya Ali Al , Jesil Anna , Achuthan M  , Walke Santosh , Rashdi Shabib Al , Balushi Noura Al , Jahan Shah
Published: April 2023

Industrial activities are the major causes of water contamination worldwide as they contain heavy metals with a high concentration leading to environmental threats and health issues. Neem bark and Date palm fiber were established in this research work as low-cost adsorbents to eliminate Copper (Cu) from synthetic wastewater. Batch studies were conducted for each adsorbent particle size of 1.18 mm and 0.6 mm. The influence of pH, contact time, adsorbent dosage, speed, temperature, and initial concentration were scrutinized. The smaller particle size (0.6 mm) was more efficient than the bigger particle size for both adsorbents. The optimum conditions for neem bark of size 0.6 mm were at an adsorbent dosage of 0.3 g, pH of 6, 30 minutes of contact time, initial concentration of 100 ppm, and stirring speed of 1000 rpm for a copper reduction of 97%. The date palm fiber of 0.6 mm resulted in a copper reduction of 91% at optimum pH 5.5, contact time of 45 minutes, stirring speed of 1200 rpm, and adsorbent dosage of 0.3 g. The adsorbents were characterized using Scanning Electron Microscope (SEM)-EDS and Fourier-transform infrared spectroscopy (FTIR). The SEM-EDS analysis displayed a carbon content of 64.1% in neem bark and 58.9% in date palm fiber. The FTIR analysis presented the functional groups in the adsorbent responsible for the adsorption of Copperas carboxyl and hydroxyl groups. In addition, the equilibrium adsorption data of Neem bark well fitted the Langmuir and Freundlich isotherm models having the correlation coefficients (R2 ) respectively as 0.9815 and 0.9024. Experimental data with date palm fiber fitted the Langmuir isotherm model with an (R2 ) value of 0.9601.
GROUNDWATER QUALITY EVALUATION USING STATISTICAL APPROACH AND WATER QUALITY INDEX IN AURANGABAD, BIHAR
Authors: Alam Aftab , Singh Anshuman
Published: April 2023

Groundwater is the primary source of drinking water in south Bihar, and its quality can potentially affect human health. To accurately anticipate and evaluate water quality, 112 samples of groundwater were collected from Aurangabad, Bihar. Samples were taken from hand pumps and bore/tube wells. Physiochemical quality parameters, namely pH, total dissolved solids, alkalinity, hardness, magnesium, calcium, sulphate, nitrate, chloride, dissolved oxygen, and electrical conductivity were measured and compared to the Bureau of Indian Standards (BIS10500:2012). The physicochemical properties of samples were evaluated to determine their water quality index (WQI). Various water quality indicators were examined and correlated with other variables. All statistical analysis was done using RStudio4.1.1 software. On water quality data, the PCA method was employed, and four components with a total variance of 75.66% were extracted. WQI of more than 98% of the samples, either of excellent or good quality. Overall, the groundwater is drinkable. Comprehensive regulation and coordinated groundwater management are needed to protect groundwater quality and to achieve one of the Sustainable Development Goals.
SEPARATION OF WATER SYSTEMS CONTAINING SURFACTANTS
Authors: Kamshybaev A. A , Iztleuov G. M , Sultanbekova P. S , Abduova A. A , Nurmasheva G. M , Yessimov Y.K
Published: April 2023

The possibility of highly efficient treatment of wastewater containing surfactants (surfactants) to a critical concentration of micelle formation by ultrafiltration (UV) by preliminary binding of surfactants into poly-complexes is shown. The effects of the parameters of the separation process and the conditions for the formation of a polycomplex on the UV efficiency indicators have been studied.
ANALYSIS OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF LEAVES OF FIG (Ficus carica L.) FROM CIWIDEY DISTRIC, WEST JAVA, INDONESIA
Authors: Saptarini N. M , R. Mustarichie  , Aulifa D. L , R. Hendriani  , Herawati I. E
Published: April 2023

Leaves of Fig (Ficus carica L., Moraceae) contain flavonoids, tannins, phenolic compounds, saponins, alkaloids, steroids, and terpenoids. These compounds create an opportunity to utilize Fig leaves as herbal medicine. This study aimed to analyze the antioxidant and antibacterial activity of Staphylococcus epidermidis and Propionibacterium acnes of Fig leaves. Antioxidant activity was conducted by the DPPH method, while antibacterial activity was conducted by the agar diffusion method, followed by the microdilution method to determine Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The results showed the IC50 values of extract, the fraction of ethyl acetate, n-hexane, and distilled water were 78.79, 22.29, 1052.00, and 133.90 µg/mL, respectively. The diameter of the inhibition zone of the extract was higher in S. epidermidis compared to P. acnes. The antibacterial activity was proportional to the extract concentration. The extract MICs for S. epidermidis and P. acnes were in the range of 6.25 and 12.5% w/v, while the MBCs value was in the range of 12.5 and 25% w/v. It concluded that the ethyl acetate fraction had the best antioxidant activity compared to the extract, distilled water, and n-hexane fraction. The antibacterial activity of the extract was better on S. epidermidis than on P. acnes.
HYDROGEN PRODUCTION FROM ETHANOL BY STEAM REFORMING OVER NICKEL AND COBALT GEOTHERMAL WASTE SUPPORTED CATALYST
Authors: J. Philia  , W. Widayat  , S. Sulardjaka
Published: April 2023

Hydrogen production was studied over nickel and cobalt geothermal waste-supported catalysts. Due to their good catalytic activity, nickel, and cobalt are widely used as catalysts in ethanol steam reforming. The geothermal waste catalyst (GWC) was synthesized by hydrothermal process, then prepared using wet-impregnation with nickel nitrate and cobalt nitrate as the precursors. SEM analysis shows that nickel and cobalt successfully adhered to the GWC, which decreased the surface area. Using nickel and cobalt in ethanol steam reforming produces a higher hydrogen yield than a GWC. The best hydrogen yield was 43.04% over Ni/GWC at 550oC. Nickel can actively break C-C, OH, and C-H bonds to produce hydrogen and reduces the brønsted acid site as the carbon formation active site.
A SIMPLE FABRICATION OF POLYVINYL PYRROLIDONE (PVP)-COATED Fe3O4 NANOPARTICLES TOWARDS IMPROVED CONGO RED DEGRADATION PHOTOCATALYTIC ACTIVITY
Authors: P.Rajeswaran  , G. Raja  , Sunderraj A. Gilbert , P. Kanagambal
Published: April 2023

PVP-coated nanoparticles are increasingly being developed for photocatalytic applications. The fabrication of PVPcoated Fe2O3 nanoparticles is demonstrated in this work using a novel method. The existence of PVP and Fe2O3 phases is identified by powder XRD analysis. SEM, FTIR, and UV techniques were used to examine the morphology and structural examination of the materials. UV–Visible DRS studies reveal optoelectronic transfer and redshifts in PVP-coated composites. Besides, the reduction of average particle size was also identified by SEM and XRD. The potential application of PVP-coated Fe2O3 as a photocatalyst was investigated with the use of an aqueous solution of degraded Congo Red dye. Data from photocatalytic research show that Fe3O4-coated PVP (6 wt%) exhibits considerably better photocatalytic activity towards the destruction of CR dyes. The improved photocatalytic activity of the hybrid composite is caused by the combination of phases of PVP and Fe2O3 with differing band gaps. Detailed evidence of the photocatalytic activity's mechanism is also provided.
BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATION OF RELUGOLIX IN PLASMA SAMPLES BY LC-MS/MS: APPLICATION TO BIOAVAILABILITY STUDY IN RABBITS
Authors: Lolla Siddhartha , Gubbiyappa Kumar Shiva
Published: April 2023

A novel, sensitive, and specific LC-MS/MS technique was developed for the quantification of Relugolix in plasma and validated as per the regulatory guidelines. Elution of Relugolix and Canagliflozin was achieved on Inertsil C18 (150mm × 2.10mm i.d, 5.0 μm particles size) column with acetonitrile and 0.1% HCOOH as a mobile phasic system in the fraction of 90:10 with a flowrate of 0.8 mL/min. The sciex API 6000 triple quadrupole mass equipment was executed with the mode of multiple reactions and m/z 624.18/127.03 for Relugolix and m/z 445.14/267.12 for the Canagliflozin, were the optimized transitions. Relugolix exhibited a rectilinear plot in the range of 3.9 – 1500.0 ng/mL concentrations. The LC–MS/MS validated methodology was efficiently utilized for the assessment of Relugolix in the rabbit plasma. From the pharmacokinetics data, the mean of Cmax and Tmax were 42.01 ± 0.99 ng/mL and 5.922 ± 0.157, individually. Plasma conc. reduced with t1/2 of 8.28 ± 0.174. AUC0→Last value obtained was 303.437 ± 8.01 ng. h/ml, respectively. In short, the method that was produced has been successfully tested, and pharmacokinetic parameters were shown after healthy rabbits were given Relugolix orally.
QUASSINOIDS FROM THE ROOTS OF Brucea javanica AND THEIR POTENTIAL CYTOTOXICITY
Authors: S. Chokchaisiri  , T. Thothaisong  , R. Chokchaisiri  , K. Savaspun  , A. Suksamrarn  , L. Ganranoo
Published: April 2023

A phytochemical study of the roots of Brucea javanica was conducted and four alkaloids and three quassinoids were isolated. The structures of the compounds were verified using physical and spectroscopic data, which were compared to the literature. The cytotoxicity of the compounds was evaluated against KB (oral cavity carcinoma), NCI-H187 (small cell lung cancer), and MCF-7 (breast adenocarcinoma) cell lines. The results showed that the quassinoid, Bruceine A, exhibited very strong cytotoxicity against KB, and high potency against NCI-H187, with both being 581- and 100-fold more active than ellipticine, and 99- and 10-fold more active than doxorubicin, respectively. These results suggest the potential use of bruceine A as an anticancer agent
BIOANALYTICAL METHOD PROCESS OF CHROMATOGRAPHIC ANALYSIS OF TIZANIDINE IN THE FORMULATION AND HUMAN PLASMA
Authors: Venkatesh D. Nagasamy , Shanmugakumar S. D. , AsfiaNajam  , Parameshwar Pabba , K. Mahendar  , Divya Bodige , E. Narsingam
Published: April 2023

An optimized, simple, accurate method is developed to quantify Tizanidine in bulk and pharmaceutical formulation using the RP – HPLC method using a silica ODS C18 column with the aid of MeOH: H2O:0.01M orthophosphoric acid ( 95:4:1 v/v/v) as a mobile phase and deduced at 320nm. The RT value was found to be 2.274 with a resolution of 1.167 respectively. The spiking studies of Tizanidine in human plasma were also carried out. The linearity studies of TZA (10 -50 mcg/mL) were found to be R2 =0.99979 (API) and R2 = 0.8155 respectively. The suggested study was validated as per the criteria of the ICH guidelines. The proposed study could be easily adopted in the pharmaceutical industry for performing quantitative analyses
GAS CHROMATOGRAPHY-MASS SPECTROMETRY PROFILING, ANTI-INFLAMMATORY EVALUATION, AND MOLECULAR DOCKING STUDIES OF ESSENTIAL OIL AND SCENTED EXTRACT FROM THE Porana volubilis Burm. f. FLOWER
Authors: T. Khammee  , J. Chokboribal  , U. Ninsuwan  , A. Saenkham  , M. Kuno
Published: April 2023

Volatile components of Porana volubilis Burm. f. flowers from Bangkok were extracted by using steam distillation and solvent extraction prior to analysis by gas chromatography-mass spectrometry (GC-MS) and their antiinflammatory activity was assessed in vitro and in silico. Forty-two compounds were identified with essential oil. The key volatile components were detected in the hexane-scented extract. Twenty-one compounds were detected with major volatile components of octacosanaol, dodecanoic acid, nonacosane, n-hexadecanoic acid, and tetratriacontane for ethanolic scented extract. The essential oil and extract were evaluated for their in vitro anti-inflammatory effect by protein denaturation assay. The essential oil showed the most potent anti-denaturation activity with IC50 values of 537.6 g/mL. The primary components of essential oil were submitted ta molecular docking research based on their anti-inflammatory effect. The obtained results revealed that the main components were found as the crucial interactions for binding in the bovine serum albumin (BSA) binding site. The results obtained demonstrated the essential oil of P. volubilis is the potential source for the anti-inflammatory agent.
MOLECULAR DOCKING ANALYSIS OF NATURAL PRODUCTS FROM Centella asiatica FOR INHIBITION OF RENIN
Authors: R.Y. Eff Aprilita , L. Ayu Ika , Eden Y. , T. Rahayu Sri , Gita Putu , W.M. Maya
Published: April 2023

Renin inhibitors derived from natural ingredients often belong to the saponin or polyphenol chemical class. Pegagan (Centella asiatica) is a natural plant in Indonesia that contains saponins and polyphenols. The active compounds of Pegagan include asiaticoside, madasiatic acid, madecassoside, madecassic acid, and asiatic acid. This study investigates the possible renin-inhibitory properties of phytochemicals from Centella asiatica using in-silico molecular docking. Using AutoDock v4.2.6, up to five C. asiatica compounds were docked with 2V0Z Renin with Inhibitor 10 (Aliskiren) in human subjects (Homo sapiens 6LU7). These compounds included asiaticoside, madasiatic acid, madecassoside, madecassid acid, and asiatic acid. SwissADME was used to evaluate these drugs' pharmacokinetic characteristics. The molecular docking results of 5 test ligands obtained affinity energy values from -8.7 kcal/mol to -10.4 kcal/mol. In contrast, the affinity energy value for the comparison ligand (aliskiren) is -9.0 kcal/mol. Madecasosside has an affinity energy value of -10.4 kcal/mol, asiaticoside of -9.6 kcal/mol and asiatic acid of -9.2 kcal/mol. Based on this energy affinity value, the active compound C. asiatica has the potential as a renin inhibitor. Pharmacokinetic analysis revealed that asiatic acid, madecassic acid, madasiatic acid, and asiatic acid have good pharmacokinetic properties. It may be concluded based on in silico molecular docking and pharmacokinetics investigation that the molecule most strongly suggested for additional in vitro renin inhibitor research was asiatic acid.
STABILITY INDICATING ISOCRATIC RP-HPLC AND SECOND DERIVATIVE UV SPECTROSCOPIC METHODS FOR SIMULTANEOUS DETERMINATION OF REMOGLIFLOZIN ETABONATE AND VILDAGLIPTIN HYDROCHLORIDE
Authors: J. Panchal  , B. Dhaduk  , J. Dhalani
Published: April 2023

Remogliflozin and Vildagliptin are the latest drug combination in order to treat type 2 diabetes. The present work describes a comparative study of 2nd-ordered derivative UV and isocratic stability indicating RP-HPLC methods for simultaneous determination of Remogliflozin and Vildagliptin in the drug and its formulation. The HPLC method was established with a C18 column and the mobile phase with Buffer (pH-6.50): Acetonitrile: Methanol ratio of 55:44:1, at 1.2 ml/min flow and wavelength of 210 nm. The UV spectrophotometric method works on spectrophotometry with 2nd order derivative spectra(2D) using a zero-line cross method. The absorbance determination was performed at 246.0 nm for REM and at 219 .6 nm for VIL. The methods were validated for Linearity, Precision, Recovery, Robustness, and Forced degradation as per ICH-Q2(R1). The linear range was established in the range of 4-80 ppm for REM and 2-40 ppm for VIL for the UV method and 2-200 ppm for REM and 1-100 ppm for VIL for the HPLC method with regression coefficient ≥0.990. The accuracy was 99.37% & 99.62% for UV and 100.98 & 100.65 for the HPLC method for REM and VIL respectively. The proposed methods have been effectively used for the quantification of REM and VIL in API mixture and formulation dosage forms. Both methods are economical, fast, simple, and accurate which can be easily adopted for laboratory use.
Trade Potential of Afghanistan with European Union: A Gravity Model Approach
Authors: Kabir Habib , Ahmad Faizan
Published: April 2023

The notion of international trade and its impact on economic growth has been phenomenal. Thus, countries to reap the trade dividends diversify their trade destinations. Against this backdrop, this study investigates the trade potential of Afghanistan with the European Union by applying the gravity model of international trade. The study used panel data for five years, from 2015 to 2019. The gravity model has been further augmented by adding GDP per capita, population, real exchange rate, inflation rate, and openness of the partner country. The co-efficient of the gravity model has been used to estimate the trade potential of Afghanistan with the European Union. The analysis used the gravity trade model, satisfying the OLS assumptions. The data revealed that Afghanistan’s bilateral trade with the EU is positively and significantly affected by its GDP, GDP per capita, exchange rate, population, inflation rate, and employment openness. The results indicate that Afghanistan has trade potential with ten European Union countries. The study's results satiate that out of the chosen fifteen countries of the European Union, the magnitude of Afghanistan's trade potential is high with three EU countries (Germany, followed by France, and Spain). The trade potential also exists for seven other countries: Sweden, the Netherlands, Belgium, Austria, Poland, Ireland, and Italy. Afghanistan is close to its trade potential with Finland and Denmark. Whereas in the case of Romania, Latvia, and Greece, Afghanistan does not enjoy any trade potential. The findings of this study are intended to help the Afghan government and traders estimate Afghanistan's trade future and consistency in European Union markets, as well as to determine whether the Afghan government can sustain its trade with those countries.
Geochemical properties and transformation of the microelement composition of soils during the development of primary diamond deposits in Yakutia
Authors: Legostaeva Yana , Gololobova Anna , Popov Vladimir , Makarov Victor
Published: April 2023

Extraction of diamonds from primary deposits in Siberia is associated with the development of kimberlite pipes in challenging environmental conditions, accompanied by a complex impact on the environment. The article presents the results of monitoring the soil cover of the Nakyn kimberlite field  in the Yakutia diamond province, which is affected by the facilities of the Nyurba Mining and Processing Division. Development of primary diamond deposits has a large-scale impact on the subsoil, topography, and soil cover: creation of the world's largest quarries, formation of dumps more than 100 m high, arrangement of extensive tailings, formation of solid and liquid industrial wastes of various chemical composition. The research is aimed at studying the spatial and temporal patterns of the technogenic impact on the soil cover, identifying the nature and level of transformation of the microelement composition of soils based on the analysis of the intra-profile and lateral distribution of mobile forms of trace elements. The study targets in 2007-2018 were zonal types of permafrost soils of northern taiga landscapes, cryozems, occupying 84 % of the total study area, which are characterized by biogenic accumulation of mobile forms of Ni, Mn, and Cd in the upper AO, Acr horizons, and Cr, Ni, Co, Mn, Cu in the suprapermafrost CR horizon. We found out that the contamination of the soil cover of the industrial site at the Nyurba Mining and Processing Division is of a multielement nature with local highly to very highly contaminated areas. Over a ten-year observation period, areas of stable soil contamination are formed, where the main pollutants are mobile forms of Mn, Zn, Ni. We suggest that against the background of a natural geochemical anomaly associated with trap and kimberlite magmatism, technogenic anomalies are formed in the surface horizons of soils. They are spatially linked to technogenically transformed landscapes. One of the sources of pollutants is the dispersion of the solid phase of dust emissions in the direction of the prevailing winds, which leads to the formation of soils with abnormally high contents of mobile forms of Mn, Zn, Ni.
H1N1 Influenza epidemic in children in Baghdad… a hospital based study.
Authors: Al-Musawi Hayder M. , Ghali Hasanein H. , Nasir Nadia A. , Hussein Wisam A. , Al-Janabi Muhi K.
Published: April 2023

Background: A confirmed case of influenza A (H1N1) virus infection is defined as a person with an influenza-like illness with laboratory confirmed influenza A (H1N1) virus infection by real-time RT-PCR or viral culture.Objectives: To identify demographic and clinical predictors, and outcome of proved cases of H1N1 influenza epidemic in children.Patients and methods: This study was conducted in Children Welfare Teaching Hospital/ Medical City/ Baghdad on 67 hospitalized patients aged 1 month to 18 years with signs and symptoms suggestive of influenza during the period of outbreak of pandemic influenza A (H1N1) from 1st of October 2009 to 1st of January 2010. Demographic aspect, clinical coarse, laboratory investigations, treatment and outcome were reported. For each patient 2 nasal, 2 throat swabs and single blood sample were collected, and sent to Central Health Laboratory. All suspected patients received Oseltamivir for 5 days. The data were analyzed statistically by Chi-square (χ2) test and Fisher’s Exact Test.Results: The median age for the studied patients was 7.7 years with a range of 1 month -18 years. 39 patients out of 67 (58.2%) were PCR positive. 34 out of 39 (87.1%) were <6-18 year old while 5 out of 39 (12.9%) were >3-6 years old. No case was reported in age group 1 month-3 years. Twenty eight patients out of 67 (41.8%) were PCR negative. 17/28 (60.7%) were <6-18 years old. 5 out of 28 (17.9%) were >3-6 years old. 6 out of 28 (21.4%) were 1 month -3 years old. Female: male ratio in PCR positive patients was 1.05:1 while it was 1.54:1 in PCR negative patients. Most of the children came from urban area in both PCR positive and negative results. Cough and fever had a higher frequency in both PCR positive and negative patients whileheadache was more in epidemic influenza. All PCR positive and 26 out of 28 (92.8%) of PCR negative patients improved while 2 out of 28 (7.2%) of PCR negative patients died.Conclusions: Children at school age were more prone to acquire epidemic influenza. Both genders were equally affected. Frequency was more in urban area .Cough and fever was the most frequent presentation. Headache was a more common presentation in H1N1 influenza than in seasonal influenza.
Damage identification in RC bridges by confronting two approaches: visual inspection and numerical analysis
Authors: Ayad Mohammed , Boumechra Nadir , Hamdaoui Karim
Published: April 2023

The present article aims to summarize the research study that was conducted the efficiency of methods and techniques designed for the detection and localization of faults in civil engineering structures, particularly in bridge structures. The diagnosis of a real reinforced concrete bridge by a visual inspection is presented. Then, three numerical damage detection and localization methods, namely the eigenfrequency change method, the eigenstrain change method (Coordinate Modal Assurance Criterion – CO-MAC), and the strain energy change method, are explicitly presented. Furthermore, the modeling of the bridge, before and after damage, using the Ansys software was carried out in order to identify all possible bridge defects. Afterward, the numerical results are graphically represented using the above mentioned methods. This made it possible to confirm the initial diagnosis and hence assess the damages observed on site and also in other zones.
Failure Analysis of Boron Steel Components for Automotive Applications
Authors: Boniardi Marco Virginio , Casaroli Andrea , Sirangelo Laura , Monella Sergio , Mazzola Michele
Published: April 2023

The automotive industry is continuously looking for an innovative mix of new steels and manufacturing techniques in order to improve process chain efficiency and cost reduction. To this aim, boron steels are becoming increasingly popular thanks to their high hardenability and machinability. Due to their reduced finishing steps, boron steels are commonly processed using fine blanking technologies. The success of fine blanking on boron steel components is due to heat treatments which must be carefully designed to avoid precipitation of boron-rich compounds that would lower steel hardenability. At high temperature, boron is very reactive with oxygen and nitrogen. The main focus of this paper is to show some drawbacks that can occur during heat treatments of automotive components. An experimental campaign was performed on two different boron steels, namely EN 34MnB5 and EN 22MnB5. The steel samples were previously spheroidized annealed in a neutral environment (hydrogen/nitrogen atmosphere), and then fine blanked to obtain specific automotive components which were subsequently quenched and tempered. Experimental tests revealed precipitation of nanometric compounds, causing strong grain refinement and localized decrease of steel hardenability. Hardenability problems were brought back to nitrogen pick-up during initial spheroidize annealing treatments.
The influence of notch connection location on the short-term behaviour of timber-concrete composite beams, modelling of TCC beams and research for optimal locations, a numerical study
Authors: Zinelaabidine Hedmessaoud , Zeineddine Boudaoud , Noureddine Ferhoune
Published: April 2023

Timber-concrete composite beams, known as TCC beams, have been widely used in rehabilitation or in new buildings where several types of connections are commonly inserted to ensure partial composite action between the timber joist and the concrete slab. The notched connections represent an effective system due to their strength and ductility and it is simple to cut from timber joists. As a result, a small number is needed for the composite beam to achieve high performance in terms of bending stiffness and load-carrying capacity. This paper aims to develop a FE model for TCC beams with notched connections. It considers realistic interactions between different components. The developed FE model can satisfactorily predict the full range load-mid-span deflection curves and the failure mechanisms. The predictions agree very well with the experimental results reported in the literature, including the stiffness and the load-carrying capacity. After the validation, a numeric study was established, it aimed to research the optimal location of a notch connection between different proposed locations, to figure out which place must be installed to ensure high performance of the TCC beams. As a result of this study, the notch installed at location P3000 was found to be the optimal location to assure the highest bending stiffness. While the maximum carrying capacity was achieved at location P3750.
On the Almost $\eta-$Ricci Solitons on Pseudosymmetric Lorentz Generalized Sasakian Space Forms
Authors: MERT Tuğba , ATÇEKEN Mehmet
Published: April 2023

In this paper, we consider Lorentz generalized Sasakian space forms admitting almost $\eta-$Ricci solitons in some curvature tensors. Ricci pseudosymmetry concepts of \ Lorentz generalized Sasakian space forms admitting $\eta-$Ricci soliton have introduced according to the choice of some special curvature tensors such as Riemann, concircular, projective, $\mathcal{M-}$projective, $W_{1}$ and $W_{2}.$ Then, again according to the choice of the curvature tensor, necessary conditions are given for Lorentz generalized Sasakian space form admitting $\eta-$Ricci soliton to be Ricci semisymmetric. Then some characterizations are obtained and some classifications have made.
Pendampingan Tata Kelola Keuangan pada Badan Keswadayaan Masyarakat Tambak Sejahtera Surabaya
Authors: Dewi Mega Arisia , Agustin Sasi
Published: April 2023

Kemiskinan merupakan salah satu masalah yang sangat besar yang dihadapi oleh negara Indonesia. Saat ini pemerintah sudah memprioritaskan kemiskinan untuk segera dituntaskan. Kemiskinan diletakkan sebagai salah satu target pembangunan yang selalu dievaluasi dari waktu ke waktu salah satunya dengan mewujudkan konsep good governance. Salah satu Lembaga yang berperan dalam pelaku kebijakan tersebut adalah  Badan Keswadayaan Masyarakat (BKM). BKM Tambak Sejahtera terletak di Kelurahan Gunung Anyar Tambak dimana kebijakan BKM dilakukan secara teknis oleh Unit Pengelola, salah satunya yaitu Unit Pengelola Keuangan. Kelurahan Gunung Anyar Tambak memanfaatkan dana BKM yang dikelola oleh UPK dalam untuk melakukan pemerataan kesejahteraan ekonomi masyarakat di lingkungan sekitar Gunung Anyar Tambak. Kegiatan ekonomi produktif dengan memberi kredit lunak dengan bunga 1,5% per bulan dengan sistem tanggung renteng selama 5 bulan. Kelompok Swadaya Masyarakat dibentuk oleh masyarakat sendiri untuk bisa melakukan kegiatan lingkungan, sosial dan melakukan kredit usaha BKM. Dana awal yang diperoleh dari pemerintah digunakan sebagai modal awal yang selanjutnya dikelola oleh manajemen BKM.
Sosialisasi Peran Paralegal Dalam Meningkatkan Pengetahuan Warga Desa Cilame Di Bidang Hukum
Authors: Pane Musa Darwin , Situmeang Sahat Maruli Tua , Alfarizzi Akmal
Published: April 2023

Community service activities through the theme of socializing the role of paralegals in increasing the knowledge of Cilame villagers in the field of law are an effort to mitigate law enforcement against potential law violations that occur in the community as a social phenomenon. In carrying out this community service, student involvement is very important considering that students as agents of change are expected to help implement legal rules. In addition, students are expected to be able to increase solidarity and concern for increasing legal awareness in society. While the results achieved in this service program are increasing legal awareness through increasing knowledge of Cilame Village residents in the field of law, especially the importance of the role of legal persons through socialization activities using lecture mechanisms, discussions. This activity is carried out so that the community understands and knows the importance of the role of paralegals. The role of paralegals is very important in fulfilling access to justice for the community, especially the poor and other vulnerable groups. In addition to preparing people who are aware of the law, paralegals also provide human rights protection to people who are dealing with the law. The results of the service program are shown by the formation of a paralegal community, increased awareness, and public knowledge of their rights in the legal field. To realize the program for establishing the role of paralegals in Cilame Village, the role of the Cilame Village government is very important, this is based on the fact that the institution is the driving force behind the progress of a village. The village government is at the forefront of dealing directly with the people who run and oversee government programs in general. Judging from the potential for increasing legal awareness, Cilame Village is quite potential for the formation of paralegals. Through this service activity, it is seen that there is an increase in public understanding of the importance of legal for the community as a form of sustainable fulfillment of human rights. During the implementation of community service activities in Cilame village it went well and got enthusiasm.
PKM Webinar “Show Up Your Mind to be a Success Entrepreneur” bagi Mahasiswa Pendidikan Biologi
Authors: Panjaitan Ruqiah Ganda Putri , Wahyuni Eko Sri , Afandi Afandi , Ningsih Kurnia , Titin Titin , Tenriawaru Andi Besse , Yuniarti Anisyah , Fajri Hayatul , Mardiyyaningsih Asriah Nurdini , Yeni Laili Fiitri , Candramila Wolly , Daningsih Entin , Rifanka Irma Naura
Published: April 2023

Saat ini jumlah wirausaha di Indonesia baru mencapai 3,3% populasi dan masih tertinggal dari beberapa negara. Mengingat rendahnya tingkat wirausaha di Indonesia dan kemudahan teknologi pada zaman ini seharusnya mengembangkan ide dan inovasi baru bukanlah hal sulit bagi kalangan muda khususnya mahasiswa. Dengan adanya teknologi pada zaman sekarang mahasiswa diharapkan mampu membangun jiwa kewirausahaan. Salah satu usaha yang dapat dilakukan untuk melahirkan wirausaha khususnya dari kalangan mahasiswa adalah dengan mendorong lembaga pendidikan untuk memasukkan pendidikan kewirausahaan dalam kurikulum dan melakukan usaha selain perkuliahan misalnya dengan webinar. Webinar kewirausahaan dengan tema “Show Up Your Mind to Be a Success Entrepreneur” dilakukan dengan tujuan agar dapat menambah minat, motivasi, dan kemampuan mahasiswa dalam berwirausaha. Metode yang dilakukan dalam webinar ini antara lain adalah sosialisasi, penyampaian materi, dan tanya jawab serta diskusi. Kegiatan webinar di fokuskan bagi alumni dan mahasiswa Pendidikan Biologi FKIP Universitas Tanjungpura. Secara umum, kegiatan webinar dikategorikan sukses dan berjalan dengan baik dibuktikan dengan jumlah peserta yang hadir dan antusias peserta webinar pada saat sesi disukusi dan tanya jawab.
Menggali Potensi Diri untuk Memulai Berbisnis
Authors: Lisdayanti Annisa , Samoedra Artarina D. A. , Bestari Dinda Kayani Putri , Dalimunthe Gallang Perdhana , Wijaya Ni Putu Nurwita Pratami
Published: April 2023

Menumbuhkan kewirausahaan yang sukses sangat penting untuk menghasilkan pertumbuhan ekonomi. Permasalahan-permasalahan yang dihadapi oleh mantan Pecandu Narkotika tidak selalu bisa menyesuaikan diri dengan lingkungan ketika ia kembali ke masyarakat. Kegiatan pengabdian masyarakat yang diharapkan dapat memberikan ilmu yang bermanfaat dan bisa diaplikasikan serta adanya rasa pengalaman tertentu yang positif. Secara umum tujuan dari kegiatan ini diharapkan masyarakat khususnya klien binaan BNNP Jawa Barat, mampu menggali potensi dirinya untuk bisa mulai berbisnis dengan melihat ide dan peluang bisnis yang ada disekitarnya. Kegiatan pengabdian kepada masyarakat (PkM) dilaksanakan secara daring dan diikuti oleh para peserta yang terdiri dari kien Binaan BNNP Jawa Barat. Ide bisnis dituntut untuk lebih berfikir keras sehingga menghasilkan kreativitas.
Pelatihan Microsoft Word pada Panti Asuhan Al-Amin Muhammadiyah (Putri) Kota Sorong
Authors: Tella Fitriyani , Setyawan Muhammad Rizki , Ermin Ermin , Faroek Dewi Astria , Ahistasari Asih , Nurfitri Nurfitri
Published: April 2023

Aplikasi Microsoft Word telah diterapkan hampir di setiap bidang pekerjaan. Begitupula pada bidang pendidikan mulai dari sekolah dasar hingga sekolah menengah atas, dimana siswa menggunakan aplikasi Microsoft Word untuk membantu dalam menyelesaikan tugas-tugas yang diberikan oleh guru. Situasi Panti Asuhan Al-Amin Muhammadiyah saat ini sudah memiliki beberapa komputer yang dapat digunakan anak-anak untuk  tugas sekolah. Namun, komputer tersebut dalam keadaan rusak dan tidak dapat digunakan oleh anak-anak. Sedangkan untuk pengurus panti asuhan, jika diminta untuk mengajari anak-anak aplikasi Microsoft Word merasa sedikit kesulitan mengingat jumlah anak panti yang banyak. Oleh karena dilakukan kegiatan pengabdian berupa pelatihan aplikasi Microsoft Word kepada anak-anak panti asuhan untuk menambah soft skill yang mereka punya serta mempermudah anak-anak dalam menyelesaikan tugas yang diberikan oleh guru. Hasil dari kegiatan ini, anak-anak panti asuhan dapat membuat sebuah surat dan mampu menggunakan aplikasi Microsoft Word untuk menyelesaikan tugas sekolah serta menambah keterampilan soft skill mereka