bluuebunny/crossref_metadata_2025 huggingface dataset:
Valorization of fat balls and primary scum from wastewater treatment: a promising renewable lipid feedstock for biodiesel production
Authors: Rizkianto Febrian , Oshita Kazuyuki , Takaoka Masaki
Published: March 2024

We investigated the potential of waste materials from wastewater treatment plants (WWTPs) to serve as an alternative lipid feedstock for biodiesel production. The average lipid recoveries from fat balls (46.4%) and primary scum (49.5–54.5%) were higher than the lipid recovery of primary sludge (15.8–16.4%). The yield of biodiesel produced from the extracted lipids ranged from 5.7 to 20.1%. There were considerable site- and season-dependent variations in the characteristics of the lipid waste materials. Radiocarbon analysis indicated the presence of fossil-derived carbon (26.0–42.0%) in the biodiesel obtained from wastewater lipids. Finally, we estimated the potential for biodiesel production from WWTP-derived lipids; about 333.0 metric tons of biodiesel per year could be produced from fat balls and primary scum in Japan. The results indicate that lipid-rich materials from WWTPs represent a valuable alternative feedstock for biodiesel production.
Evidencia de una deformación rotacional varisca a partir de braquiópodos distorsionados (Meseta, Marruecos)
Authors: Nassri Kawtar , El Adraoui Abdessamad
Published: March 2024

En 2021-2022, las obras de construcción de la carretera costera R322, que conecta la Kasbah de Oudayas (Rabat) con la localidad costera de Bouznika, han hecho posible estudiar esquistos con braquiópodos (Spirifer sp.) del Viseense sup. en la playa de Val d’Or, 12 km al suroeste de Rabat. El análisis estructural de las muestras recogidas indica una deformación de los fósiles en el plano XY del clivaje pizarroso (S1), afectados por pliegues recumbentes de vergencia oeste y por una foliación de crenulación (S2) asociada a los pliegues. Los fósiles de Spirifer sp. son triangulares, con forma de mariposa, y tienen el interés de mostrar simetría bilateral en el estado no deformado, con dos direcciones perpendiculares en T (seno o línea de simetría y charnela). Después de la deformación, estos ejes se cruzan con un ángulo agudo / obtuso que indica una deformación angular. Las medidas de los ángulos de cizalla nos llevan a reconstruir el círculo de Mohr para ángulos en el estado deformado, con objeto de obtener la forma de la elipse de deformación finita y determinar los mecanismos responsables de la distorsión utilizando el diagrama de forma de las elipses. Este método permite determinar la relación axial de la elipse de ladeformación finita mediante los círculos de Mohr. Los resultados se comparan con los obtenidos por el método de Wellman y el ábaco de Breddin. Finalmente, se propone un modelo estructural que explica las deformaciones dúctiles observadas como desarrolladas dentro zonas de cizalla dextras de dirección N-S.
Aumento en el acervo geotécnico de los constructores de hipogeos entre los Reinos Antiguo y Medio (Necrópolis Qubbet el-Hawa, Asuán)
Authors: Martínez Hermoso Juan Antonio , García Mellado Israel , Sánchez Gómez Mario
Published: March 2024

La colina de Qubbet el-Hawa fue el lugar elegido para el cementerio de los altos funcionarios de la provincia más meridional del Antiguo Egipto, desde finales del Reino Antiguo hasta finales del Reino Medio. Hasta la fecha se han descubierto, a media ladera, un centenar de tumbas excavadas en la roca distribuidas en varias terrazas superpuestas. Del estudio geológico/geotécnico se desprende que no había mejor emplazamiento, en un tramo donde predominan las areniscas, delimitado por dos estratos especialmente resistentes que sirven como suelo y techo de los hipogeos, lo que en principio garantizaba su estabilidad. En este artículo analizamos dos tumbas representativas de los dos períodos más importantes del cementerio: QH34h (Dinastía VI) y QH33 (Dinastía XII), construidas con una diferencia temporal de unos 400 años. A partir del estudio de fracturación y del análisis de la estabilidad geotécnica en estas tumbas comprobamos que la más moderna (QH33), respecto de la más antigua (QH34h), presenta innovaciones constructivas y de diseño que solucionaron los problemas de estabilidad que presentaban algunas de las tumbas más antiguas. Este estudio demuestra que, en primer lugar,  la elección del emplazamiento de las tumbas se realizó en función de la naturaleza resistente de los estratos, en segundo lugar, que los métodos  constructivos utilizados por los antiguos egipcios estaban condicionados por la geología de la colina y, en tercer lugar, que, resultado de la experiencia adquirida durante años, el diseño de las tumbas evolucionó para solucionar los problemas de estabilidad del macizo rocoso.
Use of Chitosan as a Precursor for Multiple Applications in Medicinal
Chemistry: Recent Significant Contributions
Authors: Quiroga Diego , Coy-Barrera Carlos
Published: March 2024

Chitosan (CS) is a polymer made up of mainly deacetylated β-1,4 D-glucosamine units,
which is part of a large group of D-glucosamine oligomers known as chitooligosaccharides, which
can be obtained from chitin, most abundant natural polymer after cellulose and central component of
the shrimp exoskeleton. It is known that it can be used for the development of materials, among
which its use stands out in wastewater treatment (removal of metal ions, dyes, and as a membrane in
purification processes), food industry (anti-cholesterol and fat, packaging material, preservative, and
food additive), agriculture (seed and fertilizer coating, controlled release agrochemicals), pulp and
paper industry (surface treatment, adhesive paper), cosmetics (body creams, lotions, etc.), in the engineering
of tissues, wound healing, as excipients for drug administration, gels, membranes, nanofibers,
beads, microparticles, nanoparticles, scaffolds, sponges, and diverse biological ones, specifically
antibacterial and antifungal activities. This article reviews the main contributions published in
the last ten years regarding the use and application of CS in medical chemistry. The applications
exposed here involve regenerative medicine in the design of bioprocesses and tissue engineering,
Pharmaceutical sciences to obtain biomaterials, polymers, biomedicine, and the use of nanomaterials
and nanotechnology, toxicology, and Clinical Pharmaceuticals, emphasizing the perspectives and
the direction that can take research in this area.
Computational Molecular Docking and In-Silico, ADMET Prediction Studies of
Quinoline Derivatives as EPHB4 Inhibitor
Authors: Mhaske Ganesh S. , Thorat Sanket R. , Pawar Varun S. , Pawar Ravindra S. , Jambhulkar Sarvesh R. , Ghumre Omkar A.
Published: March 2024

Background::

The creation and development of novel chemical entities is made possible by numerous computer-aided drug design techniques. The ability to
visualize the ligand-target interaction and forecast the important holding pocket locations and affinities of ligands to their intended macromolecules
is made possible by pharmacophore-based drug design and understanding in-silico methodologies.

Objective::

The aim of the current investigation was to find novel 2-chloroquinoline-3-carboxamide derivatives that target the Ephrin B4 (EPHB4) receptor to
treat cancer.

Materials and Methods::

Chem Axon Marvin Sketch 5.11.5 was used to create derivatives of 2-chloroquinoline-3-carboxamide. The physicochemical characteristics of
compounds as well as their toxicity were predicted using SwissADME& the admet SAR online software’s. Molecular docking technology was
used to examine the ligand-receptor interactions of 2-chloroquinoline-3-carboxamide derivatives with the target receptor (PDB- 6FNM) using a
variety of software’s, including Autodock1.1.2,Procheck, ProtParam tool, Biovia Discovery Studio Visualizer v20.1.0.19295, MGL Tools 1.5.6,
PyMOL, and were all included.

Results::

All developed compounds were determined to be orally bioavailable, less toxic, and have acceptable pharmacokinetic properties according to in
silico studies. In comparison to the traditional medication Erdafitnib, all new compounds displayed higher docking scores.

Conclusion::

The increase in binding energy and the number of H-bonds created by novel derivatives with interactions at distances below 3.40A provide a
helpful starting point for formulating and synthesizing compounds that are most suitable for additional research. The application of the 2-
chloroquinoline-3-carboxamide moiety as a potential new cancer treatment candidate is supported by its pharmacokinetics &toxicological profile,
which may aid medicinal chemists in conducting more in-depth in vitro, in vivo chemical and pharmacological studies.
Potential Beneficial Effects of Mineral Sunscreens on Acne-Prone Skin
Authors: Gomes Marina , Vieira Lima Fabiana , Rosado Catarina , Pezzini Bianca Ramos
Published: March 2024

Background:

Sunscreens are critical products used against harmful ultraviolet (UV)
radiation. However, beyond the effect of sun protection, the inorganic UV filters zinc oxide and
titanium dioxide have shown antimicrobial activity.

Objective:

This study aimed to evaluate the potential additional beneficial effects of mineral sunscreens containing zinc oxide and titanium dioxide as antimicrobial agents on acne-prone skin.

Methods:

Transepidermal water loss, skin hydration, and skin pH of twelve volunteers were
measured before and 2 h after the application of three mineral sunscreens. The antimicrobial activity of the mineral sunscreens was determined against Cutibacterium acnes, Staphylococcus
aureus, and Staphylococcus epidermidis in a time-kill test.

Results and Discussion:

The studied mineral sunscreens did not affect either the stratum corneum
hydration or its integrity, but they increased the skin pH from 4 to 6, which could impact the skin
microbiota balance. At the same time, the tested mineral sunscreens inhibited Cutibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus.

Conclusion:

This study suggests that the two UV filters can have positive effects on acne-prone
skin and, thus, extend the benefits of photoprotective formulations. Nevertheless, further research
is currently being conducted.
Covid-19 Aşısı Olan Sağlık Profesyoneli Öğrencilerinin Koronavirüs Anksiyete Düzeyleri ile Sağlık Okuryazarlığı Arasındaki İlişkinin Belirlenmesi
Authors: Öztürk Haney Meryem , Şenyiğit Arda , Çelik Gülbahar , Çil Doğuhan , Yılmaz Mehmet Birhan
Published: March 2024

Amaç: Bu araştırmanın amacı, COVID-19 aşısı olan sağlık profesyoneli öğrencilerinde koronavirüs anksiyetesi ve sağlık okuryazarlığı ilişkisinin belirlenmesidir.
Yöntem: Kesitsel türdeki araştırma, bir üniversitenin sağlık bilimleri bölümlerinde eğitim gören, COVID-19 aşısı olan ve hastanede klinik uygulama yapan 216 öğrenci ile yürütülmüştür. G Power programı kullanılarak örneklem büyüklüğü 152 olarak belirlenmiştir. Araştırmaya dahil olma kriteri: tıp, hemşirelik ve fizik tedavi ve rehabilitasyon bölümü öğrencisi olmak, araştırmaya katılmayı kabul etmek, COVID-19 aşısı olmak ve hastanede klinik uygulama yapıyor olmaktır. Formları eksik dolduran, 18 yaşından küçük, COVID-19 aşısı olmayan, hastanede klinik uygulama yapmayan, son sınıf öğrencileri ile klinik uygulama yapmayan sınıflardaki öğrenciler araştırmaya dahil edilmemiştir. Veriler çevrimiçi olarak, Koronavirüs Anksiyete Ölçeği, Sağlık Okuryazarlığı Ölçeği ile toplanmıştır. Veri analizinde, Mann-Whitney U testi, Kruskal-Wallis H testi ve Spearman korelasyon analizi kullanılmıştır.
Bulgular: Öğrencilerin yaş ortalaması 21.22 ± 2.47, %24.5’ü erkek, %17.1’i tıp, %29.6’sı fizik tedavi ve rehabilitasyon, %53.2’i hemşirelik bölümü öğrencisi idi. Katılımcıların sağlık okuryazarlığı toplam puan ortalaması 108.23 ± 12.35, koronavirüs anksiyete puan ortalaması 2.53 ± 4.01 olarak belirlenmiştir. Öğrencilerin %10.2’si koronavirüs anksiyete belirtisine sahipti. COVID-19 geçiren, klinik uygulama endişesi olan ve kadın öğrencilerin koronavirüs anksiyete puanı daha yüksek olarak belirlenmiştir (p<0.05). Klinik uygulama endişesi olmayan, tıp öğrencisi ve büyük yaş grubundaki öğrencilerin sağlık okuryazarlığı puanı daha yüksek olarak belirlenmiştir (p<0.05). Öğrencilerin COVID-19 aşısının etkili olduğunu düşünme durumuna göre, sağlık okuryazarlığı ve koronavirüs anksiyete puanları arasında istatistiksel olarak anlamlı bir fark belirlenmemiştir (p>0.05). Sağlık okuryazarlığı ile koronavirüs anksiyete puanı arasında ters yönlü bir ilişki belirlenmiştir (p<0.05).
Sonuç: Öğrencilerin, koronavirüs anksiyete belirtilerinin düşük, sağlık okuryazarlığının iyi düzeyde olmasına rağmen, sağlık okuryazarlığı yetersiz olan öğrencilerin koronavirüs anksiyete belirtilerinin daha yüksek olduğu belirlenmiştir. Sağlık profesyoneli bölümlerinin eğitim müfredatlarına sağlık okuryazarlığı içeriğinin dahil edilmesi ve öğrencilerin rahat erişim sağlayabilecekleri psikolojik danışmanlık hizmetlerinin arttırılması önerilmektedir.
Social Network Analysis on Knowledge Sharing in Swiftlet Ranching Industry in Gua Musang
Authors: Alpandi Rabiatul Munirah , Kamarudin Fakarudin , Ya'acob Fatin Farazh , Kurniasih Lulus
Published: March 2024

This paper utilizes social network analysis to identify key stakeholders in Gua Musang's Swiftlet Ranching industry, focusing on knowledge shari ng in ranch management. The study underscores the pivotal role of government agencies as information distributors, revealing a modest 39.92% centralization closeness in knowledge sharing among stakeholders. Recognizing these influential stakeholders is crucial for implementing effective policies and information dissemination, essential for the industry's success and increased edible bird's nest production.
Level of Occupational Balance among Retirees in Malaysia
Authors: Menon Qistina Taqifa , Che Daud Ahmad Zamir , Isa Siti Nor Ismalina , Ranabhat Manoj Kumar
Published: March 2024

Occupational balance has been proven to benefit retirees’ health and can significantly improve their life satisfaction and quality of life post-retirement. This study aims to examine the level of occupational balance among retirees in Malaysia. A cross-sectional study was conducted using purposive sampling to recruit 400 participants from the retiree population. Based on the findings, the mean of OBQ11 total scores was 22.96 (SD = 4.79), with a minimum score of 10.00 and a maximum score of 33.00. To conclude, this study showed that retirees in Malaysia have a high level of occupational balance.
Bosch’s Brush: Imagination and Reality in 15th-Century Dutch
Authors: Ding Jingwen , Shaari Shahrul Anuar , Tong Hoey Chin Christy , Zhang Long
Published: March 2024

This study examines the sociocultural and psychological aspects present in Hieronymus Bosch's renowned artworks, "The Gardens of Earthly Delights" and "The Last Judgment," utilising historiography, iconography, and an analytical checklist. The findings revealed that intricate stories question established social standards and add to a deep sociocultural conversation, uncovering a diverse range of societal stories that enrich the comprehension of the complex and numerous elements of quality of life in the 15th-century Netherlands. The visionary art of Bosch has a significant impact on the ongoing sociocultural conversation, encouraging deep contemplation of the complexities of existence in the 15th century, which improves the quality of life.
Mc-TCIM: the integration of Aboriginal and Borneo traditional crafts in visual arts education
Authors: Maaruf Siti Zuraida , Ahamed Kamal Akmal , Rahmat Mohd Khairezan , Majid Sheikha Majid , Swaramarinda Darma Rika Swaramarinda
Published: March 2024

Multicultural Traditional Craft Interactive Module (Mc-TCIM) enhances culturally responsive pedagogy in secondary school Visual Arts Education (VAE). The study’s objectives are to determine teachers' acceptance of developing interactive multicultural traditional craft modules as a teaching method. It justifies their classroom use, promoting diversity awareness and appreciation. Through survey analysis, it assesses teachers' opinions, perceived benefits, and challenges in integrating these modules. Aimed at creating effective pedagogical tools, this research clarifies instructors' acceptance levels to support cultural diversity, enhance learning experiences, and foster inclusive educational practices.
Nanjing Baiju: Balancing heritage and innovation in contemporary China
Authors: Wu Rui , Sharifah Faizah Syed Mohammed
Published: March 2024

This study examines the modernization of traditional Chinese Baiju opera while preserving its original essence through an exploration of its history, characteristics, and adaptation to contemporary trends. The research uses qualitative methods such as literature review, case studies, and surveys, with limitations including reliance on existing literature and subjective audience feedback. Findings reveal a balance between traditional authenticity and contemporary influences, shedding light on a generational gap in audience acceptance and extending to a broader discussion of preserving traditional arts in a globalized context.
Sociodemographic association in the hemodynamic challenge of early mobilization post-cardiac surgery.
Authors: Wan Ismail Wan Marina , Hashim Siti Nur Aishah , Cheong Ping Pau , Ariani Fatmawati
Published: March 2024

Decreased functional capacity in post-cardiac surgery often leads to muscle atrophy and inactivity. Prolonged bed rest is the main contributor to the delay in recovery. This study investigates the association between hemodynamic challenge during early mobilization and socio-demographic factors with clinical cardiac monitoring such as gender, Body Mass Index (BMI), EuroSCORE in post-cardiac surgery patients. The finding showed gender, BMI, and EUROScore were associated with a hemodynamic challenge during early mobilization. In conclusion, the study suggests that early mobilization post-cardiac surgery is not only safe but cost-effective for the institution and the government.
Influence of Perceived Value on Clients' Behavioural Intention in Online Psychological Counseling
Authors: Cheng Chunhua , Md Nor Mariani , Gao Jia , An Siya
Published: March 2024

This study employed quantitative research methods to survey 400 customers in China who had used online psychological counseling. Subsequently, SmartPLS4.0 was used to conduct structural equation modeling to test the comprehensive relationship between variables. The research demonstrates the role of emotional experience, perceived usefulness, and ease of use in determining user intent. Conversely, there is a negative correlation with perceived cost. The findings suggest that cost plays a significant role in user decision-making when it comes to online psychological counseling. These results provide valuable insight into how users perceive such services and can guide their development.
Factors Influencing Property Overhang in Residential and Serviced Apartments in Malaysia: A Thematic Review
Authors: Ishak Noor Farhana Akrisha , Ahmad @ Baharum Zarita , Ting Kien Hwa , Marzuki Jufri
Published: March 2024

The one-decade data on residential and serviced apartment overhang indicates that overhang occurs in Malaysia and should not be taken lightly. This paper aims to identify the factors influencing property overhang by adopting a thematic analysis. ATLAS.ti 23 was used to conduct thematic analysis. The findings revealed eleven main themes of factors in property overhang in Malaysia based on the pattern highlighted in the literature. The outcomes are expected to benefit the direction of future research and developing solutions, especially for the agencies and stakeholders such as the state and local authorities and developers to work together.
Comparative Studies of Real Estate Agency Practices and the Way Forward
Authors: Ahmad Zarita , Mohd Salleh Sharuzaman , Kien Hwa Ting , Yam Sharon
Published: March 2024

This paper conducted a comparative analysis between Malaysia, Singapore, Indonesia, Australia, and Hong Kong. The study contrasted real estate agency practices based on their practices and regulatory bodies. The cross-comparative analyses displayed evidence of commonalities in the ways that regulatory organizations, registration, and codes of ethics are implemented. The paper will be used as a platform for more in-depth studies to ensure that Malaysia's real estate agency practices are sustainable and robust.
Postoperative Cognitive Dysfunction and Virtual Reality for Cognitive Rehabilitation in Cardiac Surgery Patients: A Short Review
Authors: Tarasova Irina , Trubnikova Olga
Published: March 2024

Postoperative cognitive dysfunction (POCD) has been observed as a complication after cardiac surgery consistently. The ineffectiveness of current treatments for POCD is causing a search for non-invasive alternatives. The present review aims to consolidate the current understanding of how VR methods effectively facilitate the recovery of cognitive functioning in cardiac surgery patients. To obtain information about the effects of VR technology on cognitive functions, we investigated the PubMed, Scopus, and Web of Science Core Collection databases. Our research has shown that VR systems effectively provide feedback, adapt to individual needs, and provide high-intensity and meaningful exercise to promote cognitive and motor learning. Previous studies have demonstrated that multisensory and multidomain stimulation of cognitive functions is possible through VR technology. Thus, the cognitive rehabilitation of cardiac surgery patients can be significantly enhanced using virtual reality (VR) technologies.
Examining Individuals’ Use of the Internet for Health Care Activities Over Time: Results from the US National Health Interview Survey (Preprint)
Authors: Junkins Zachary , Zahan Nusrath , Neyens David
Published: March 2024

BACKGROUND

Telehealth is an increasingly important component of health care services. Telehealth services may present an opportunity to increase the equity, accessibility, and effectiveness of health care. As such, it is critical that telehealth design focuses on reducing the barriers to access and usability that may impair some telehealth users.

OBJECTIVE

Our goal was to identify different demographic characteristics, behaviors, or opinions that may predict groups who are likely to face a barrier to using telehealth services.

METHODS

We used data from the National Health Interview Survey and multiple logit regression models focused on different aspects of telehealth to examine three different avenues of telehealth service: looking up health information using the internet, scheduling an appointment using the internet, and communicating with a care provider through email using the internet in order to consider the ways in which different telehealth services may face different barriers.

RESULTS

Our results suggest that middle-aged (36-55 years old) and older adult (56-85 years old) respondents were significantly less likely to look up health information using the internet or schedule an appointment using the internet versus younger individuals (18-35 years old). Specifically, our analysis found that middle-aged adults were found to have a higher odds ratio than older adults (0.83 vs 0.65) for looking up health information using the internet. We also found that there were differences in age groups for using technology to perform health care–related tasks. In terms of searching for health information using the internet and scheduling appointments using the internet, we found differences between men and women, with women being significantly more likely than men to look up health information using the internet, schedule an appointment using the internet, and communicate with a care provider through email using the internet. Across all the investigated variables, we found that the rates of using the internet for looking up health information, scheduling an appointment, and communicating with a care provider over email increased substantially across the study period. The impact of costs was inconsistent across the different models in our analysis. We also found that there is a strong correlation between respondents’ collaboration in their personal health and the likelihood that they would use telehealth services to meet these needs.

CONCLUSIONS

This analysis provides an exploratory look at the data to highlight barriers that may impact a user’s ability to access telehealth services in the context of other potential predictor variables to account for the real-world variability that these may present. Future work should examine the complex relationships of those variables and understand how these interactions are correlated with the respondents’ use of telehealth.
Nuclear law: Scientometric study of the scientific literature indexed by the Scopus database between 1970 and 2023 using VOSviewer
Authors: Santos A Almeida dos , R. Souza Lima. , C Araripe Marinho. , E Assumpção Silva.
Published: March 2024

Nuclear law refers to the legal framework that governs the development, regulation, and use of nuclear energy and technology. The gap that this study seeks to fill concerns the use of the scientometric method, based on an information structure found in indexed scientific studies on the evolution of the theme of nuclear law. The present study aimed to map out the themes of scientific production between 1970 and the first semester of 2023. Data were collected from research activities indexed by the SCOPUS database and analyzed with the aid of the scientometric VOSviewer software. Considering the limitations of this study, the main scientometric results related to the theme of nuclear law are the following: the United Kingdom and the United States of America present the greatest collaboration in co-authorship between countries; the subject has a broader scope in the field of social science and no significant impact or frequency of Brazilian publications or authors was identified. It was concluded that nuclear law, in line with legal and ethical principles, can contribute to the wellbeing of humanity and the preservation of the environment.
Геометрия контакта и технологические аспекты затылования зубьев зуборезных червячных фрез. Часть I. Определение параметров фрез и линий контакта при затыловании
Authors: Сандлер А.И.
Published: March 2024

Определены основные параметры боковых поверхностей зубьев зуборезных червячных фрез и геометрия контактных линий при операции их радиального затылования.
Advances in Sensor-Based Detection and Machine Learning for Osteoporosis: A Comprehensive Survey of Diagnostic Techniques
Authors: Budyal Vijayashree R , N Disha H , Suresh Inchara H , Bhatt Shreyas V
Published: March 2024

Abstract: One of the biggest challenges in the field of healthcare is the early identification of bone diseases. The increasing demand for diagnostic services often overwhelms current approaches, leading to increased healthcare costs, delayed identification, and patient discontent. To solve this problem, an Osteoporosis Early Detection System incorporating Biosensors and Machine Learning via the Internet of Things (IoT) is desperately needed. Osteoporosis difficulties and increased health risks are similar to congestion challenges that they might arise from delayed diagnosis. The scarcity of adequate technologies for early osteoporosis detection hinders effective healthcare delivery, especially in areas where the condition is more prevalent or during screenings that need quick identification. In order to enable prompt identification and notify medical professionals for preventive action, certain healthcare institutions have started including biosensors that can track changes in bone density. The development of these technologies could revolutionize the early diagnosis and treatment of osteoporosis and lessen the effects of the condition on patient’s health outcomes.
Combination of neuromuscular block monitoring and hand grip strength assessment for patients undergoing emergency abdominal surgery
Authors: Dhunputh Neelam , Petrova Marina V. , Moroz Victor V. , Butrov Andrey V. , Magomedov Marat F.
Published: March 2024

Relevance. The hand grip strength measurement together with neuromuscular block monitoring played an important role during surgery. They both helped in losing less time during surgery and also facilitate the task of the surgeon. The aim of this study was to reduce time on intubation, facilitate the task of the surgeon and to limit post-surgical pain. In rehabilitation, hand grip strength helps in determining further recuperation measures after asurgery. There are three fundamental principles for an anesthesiologist to ensure that the patient after combined endotracheal anesthesia can be extubated, the first one is to ask the patient to move his head forward, the second one is to ask the patient whether the intubation tube is disturbing him in his mouth and the third most important one is to make the patient hold his wrist very firmly. Materials and Methods. Monitoring of muscle relaxant on induction, intra and post-surgery is carried out using aTOF Watch SX in coordination with handgrip strength measurement on 46 patients aged from 18 to 60 years of BMI of 18-30 kg/m² 15min before endotracheal intubation and 15min, 45min and 210min post extubation by using adynamometer “MEGEON 34090” to help us understand whether after extubation muscle strength changes and to what extent. Also, pre-anesthesiology protocol, combined endotracheal protocol, Microsoft excel advanced, monitoring of hemodynamics, ECG, PEEP, PCO2, PO2, respiratory volume using Drager Fabius. Results and Discussion. The results showed that to reach deep muscle relaxation both atracurium benzilate (FKP Kursk Biofabric company, Kursk, Russia) at TOF 0 took 258.5± 83.5 secs and Cisatracurium benzilate (ZAO Obninsk Chemical pharmaceutical company, Obninsk, Russia) at TOF0-252.4±100.1 secs in emergency patients and basically hand grip strength also was lesser as compared to planned cholecystectomy patients. Conclusion. Rehabilitation was necessary for patients undergoing massive abdominal emergency surgeries underlying the fact that on apain scale 10/10 post surgery, further treatments should be implemented to reduce pain, reduce residual neuromuscular block and muscle weakness after extubation at TOF 90-95%.
Obstetric, somatic and infectious risk factors for vulva sclerotic lichen
Authors: Osipova Lyudmila K. , Kolesnikova Ekaterina V. , Zharov Alexander V. , Penzhoyan Milena A.
Published: March 2024

Relevance. Until now, disputes among scientists about its etiology, pathogenesis, nomenclature and risk factors for the development of vulvar lichen sclerosis have not subsided, which actualizes the need for scientific research aimed at solving these problems. The aim of the study - to establish statistically significant clinical and anamnestic risk factors for vulvar lichen sclerosis. Materials and Methods. An electronic database was formed with data from 344 patients with lichen sclerosus of the vulva and 60 women without vulvar diseases aged 20-70 years on hereditary, obstetric-­gynecological, somatic and infectious history. Astatistical comparative correlation analysis of the obtained data was carried out using the Spearman correlation coefficient (R0.15), nonparametric Mann - Whitney U test and Student t test (p0.05), Chi-square tests, Phi and Cramer statistics. Results and Discussion. Statistically significant (p0.05) risk factors for the development of vulvar lichen sclerosus (R, in descending order) were established: the presence of fibrocystic mastopathy (-0.29); late menarche (15 years and older) (-0.28); onset of menopause (-0.25); recurrent vulvo-­vaginal infections (-0.18); recurrent bacterial vaginosis (-0.18); autoimmune thyroiditis(-0.16) and stage II obesity (-0.16). Also, the average number of abortions and births (1.23 and 1.49, respectively) in the group of patients with lichen sclerosis of the vulva is statistically significantly greater (p0.05) than the average value (0.27 and 1.13, respectively) in control group. Conclusion. The data obtained on the impact of obesity and autoimmune thyroiditis on the risk of developing vulvar sclerotic lichen are consistent with the results of global studies and confirm the association of the disease with autoimmune and metabolic disorders. Recurrent vulvo-­vaginal infections and dysbiotic processes in the vagina can be both acause and aconsequence of vulvar lichen. The relationship between fibrocystic mastopathy and vulvar lichen sclerosus remains debatable and requires further research. Late menarche, the onset of menopause, alarge number of abortions and childbirth can also be considered triggers for vulvar lichen sclerosus in patients with agenetic predisposition to the disease.
Magnetic field application in bone tissue regeneration: issue current status and prospects for method development
Authors: Muraev Alexandr A. , Manukyan George G. , Salekh Karina M. , Bonartsev Anton P. , Volkov Alexey V.
Published: March 2024

Relevance. Magnets have long been used to treat various diseases, especially in inflammatory processes. According to existing historical data, magnetotherapy was already used in ancient times by the Chinese, Egyptians and Greeks. Different magnetic field strengths affect cells in different ways, with medium-strength magnetic fields being the most widely used. The review presents a brief history and current state of the issue of using a magnetic field in bone tissue regeneration. Modern knowledge about the mechanisms of physiological and reparative regeneration, restoration of bone tissue is clarified, and modern areas of bone tissue engineering are considered, taking into account the characteristics of microcirculation and the effect of a magnetic field on the physiology of bone tissue and reparative regeneration. One of the key findings of the review is that the magnetic field improves bone tissue repair by influencing the metabolic behavior of cells. Studies show that magnetotherapy promotes the activation of cellular processes, accelerates the formation of new bone tissue and improves its quality. It is also noted that the magnetic field has a positive effect on microcirculation, improving the blood supply to tissues and facilitating a better supply of nutrients to the site of injury. This contributes to faster wound healing and early rehabilitation of patients. Conclusion. Magnetotherapy is one of the effective physical and rehabilitation methods of treatment that will become increasingly important in modern medicine. However, further research is needed to better understand the mechanisms of action of a magnetic field on bone tissue and to determine the optimal parameters for its application.
EDITORIAL NOTE
Authors: Hassan Asmadi , Govindasamy Geetha
Published: March 2024

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LITERASI DIGITAL BERBASIS VIDIOGRAFI TERHADAP TOXIC RELATIONSHIP SISWA SMA
Authors: Manuardi Ardian Renata
Published: March 2024

Literasi digital merupakan pengetahuan serta kecakapa pengguna dalam memanfaatkan media digital, seperti alat komunikasi, jaringan internet, dan sebagainya. Kecakapan pengguna dalam literasi digital mencakup kemmampuan untuk menemukan, mengerjakan, mengevaluasi, menggunakan, membuat, serta memanfaatkannya dengan bijak, cerdas, cermat, dan tepat sesuai dengan kegunaannya. Penelitian ini bertujuan untuk mengetahui pengembangan literasi digital dengan menggunakan vidiografi mengenai toxic relationship di kalangan siswa SMAN 4 Bandung. Pemilihan penelitian ini berdasarkan banyaknya permasalahan yang dihadapi oleh para siswa dalam fase remaja awal yang masih membentuk jati diri dengan mengadaptasi pengaruh-pengaruh lingkungan di sekitarnya. Dengan penggunaan literasi digital, diharapkan dapat membantu siswa untuk mampu memanfaatkan media digital dalam memecahkan permasalahannya, salah satunya yaitu masalah toxic relationship. Penelitian ini menggunakan metode pendekatan deskriptif kualitatif untuk memberikan gambaran mengenai toxic relationship dengan menggunakan vidiografi dalam memecahkan masalah pribadi maupun sosialnya dengan mengadopsi 6 dari 10 langkah menurut Brog & Gall.
Efektivitas Konseling Kelompok Behavior Teknik Modeling Untuk Meningkatkan Kecerdasan Sosial Bagi Siswa Sekolah Menengah Pertama di Kota Semarang
Authors: Aini Mila Khurotul
Published: March 2024

Penelitian ini bertujuan untuk mengetahui keefektifan konseling kelompok pendekatan behavior dengan teknik modeling guna meningkatkan kecerdasan sosial siswa. Desain eksperimen one group pretest-posttest digunakan dalam penelitian ini dengan melibatkan lima siswa sebagai partisipan. Teknik pengambilan subjek penelitian menggunakan purposive sampling. Alat pengumpul data yang digunakan adalah skala kecerdasan sosial merujuk pada teori Daniel Goleman sebanyak 8 indikator dan 44 item. Koefisien validitas yakni 0.220, dan reliabilitas menggunakan Î± Cronbach dengan koefisien reliabilitas 0.919. Analisis uji Wilcoxon digunakan untuk menguji hipotesis. Hasil penelitian menunjukkan bahwa rerata tingkat kecerdasan sosial sebelum perlakuan menunjukkan kategori sedang (M=2.47, SD=0,58). Selanjutnya uji hipotesis menunjukkan bahwa konseling kelompok behavior teknik modeling terbukti secara signifikan (Z= -5.315, pË‚0.05) untuk meningkatkan kecerdasan sosial siswa. Selanjutnya, konselor sekolah/Guru BK dapat menerapkan serta mengembangkan layanan konseling kelompok behavior teknik modeling sebagai salah satu alternatif strategi dalam meningkatkan kecerdasan sosial siswa.
STRATEGI LAYANAN BIMBINGAN KARIER: PERSPEKTIF KARIER DITINJAU DARI PERKEMBANGAN SISWA PADA JENJANG SEKOLAH DASAR
Authors: Suherman Maya Masyita , Siddik Riesa Rismawati
Published: March 2024

Career is a lifelong process, so it needs to be formed as early as possible to achieve a career that suits the individual. Career education can be started when the child is in elementary school. At this level, children begin to be introduced to jobs in the surrounding environment. In addition, teachers, parents and the community participate in providing learning about themselves to children related to gender, morals, social skills, Self-Esteem, and Self-Efficacy. The formation of one's career must start early, so that since elementary school a child must be given an understanding of career. The understanding given can be through games by introducing jobs that exist in the environment around the home and school. Career development for children also needs to be adjusted to their developmental tasks. as parents and teachers must also know the talents and interests of children from an early age to be able to better direct children. The directives carried out here are not coercion in accordance with the wishes of the parents/teachers, but according to the potential of the child.Keywords:Â Â Â service strategy, career guidance, elementary school
Implementasi Konseling Keluarga Berbasis Nilai-nilai Islam
Authors: Alawiyah Tuti
Published: March 2024

Bimbingan dan konseling keluarga berbasis nilai-nilai Islam merupakan suatu proses interaktif yang bertujuan untuk membantu keluarga mencapai kesejahteraan dan keseimbangan dalam hidup. Proses bimbingan dan konseling berbasis nilai-nilai Islam berorientasi pada bagaimana individu dalam keluarga dapat memfungsikan seoptimal mungkin aspek-aspek dari spiritualitasnya dalam menyelesaikan permasalahan-permasalahan keluarga yang sedang dihadapi untuk mendapatkan kebahagiaan dan kesejahteraan dalam kehidupannya. Penelitian ini bertujuan untuk mengetahui pengimplementasian konseling keluarga berbasis nilai-nilai keislaman melalui pendekatan naratif dimana penulis mengeksplorasi pendapat responden yang diperoleh melalui wawancara mendalam (indepth interview). Aspek-aspek yang ditelaah difokuskan pada tema-tema berikut. 1) tujuan pernikahan menurut Islam, 2) tujuan berkeluarga menurut Islam. 3) cara membina keluarga menurut Islam, 4) pemahaman terhadap kondisi diri, keluarga, dan lingkungan, 5) memahami problem yang dihadapi menurut Islam, 6) cara mengatasi masalah keluarga menurut Islam. Hasil penelitian ini diharapkan dapat memberikan gambaran kepada konselor keluarga berkaitan dengan bagaimana nilai-nilai Islam dapat diintegrasikan kedalam proses bimbingan dan konseling keluarga.
Mechanistic insights into an ancient adenovirus precursor protein VII shows multiple nuclear import receptor pathways
Authors: Alvisi Gualtiero , Nematollahzadeh Sepehr , Athukorala Ajani , Donnelly Camilla M. , Pavan Silvia , Atelie-Djossou Victoria , Iorio Enzo Di , Nath Babu , Helbig Karla J. , McSharry Brian , Forwood Jade K. , Sarker Subir
Published: March 2024

Adenoviral pVII proteins are multifunctional, highly basic, histone-like
proteins that can bind to and transport the viral genome into the host
cell nucleus. Despite the identification of several nuclear localization
signals (NLSs) in the pVII protein of human adenovirus 5 (HAdV5), the
mechanistic details of nuclear transport are largely unknown. Here we
provide a full characterization of the nuclear import of precursor
(Pre-) pVII protein from an ancient siadenovirus, frog siadenovirus 1
(FrAdV1) using a combination of structural, functional and biochemical
approaches. Two strong NLSs (termed NLSa and NLSd) interact with
importin (IMP)b and IMPa respectively, and are the main drivers of
nuclear import. A weaker NLS (termed NLSb) also contributes, together
with an additional signal (NLSc) which we found to be important for
nucleolar targeting. Expression of Pre-pVII wild-type and NLS defective
derivatives in the presence of selective inhibitors of different nuclear
import pathways revealed that, unlike its human counterpart, FrAdV1
Pre-pVII nuclear import is dependent on IMPa/b and IMPb1. Clearly, AdVs
evolved to maximise the nuclear import pathways for the pVII proteins,
whose subcellular localization is the result of a complex process.
Therefore, our results pave the way for an evolutionary comparison of
the interaction of different AdVs with the host cell nuclear transport
machinery.
Identifying prominent genotypes and yield contributing traits in finger millet (Eleusine coracana L.)
Authors: Bairwa Ujala , Choudhary B.R. , Bhardwaj Rahul
Published: March 2024

The knowledge about genetic variability and determining the criteria for
employing effective selection is always prerequisite to develop a sound
breeding programme. Therefore, the present experiment was conducted with 35
genotypes of finger millet in Randomized Block Design (RBD) with three (03)
replications and observations were recorded for morphological and quality
traits. The analysis of variance exhibited substantial degree of variability
among the genotypes for all the traits under study. The higher value of
phenotypic coefficient of variance (PCV) than genotypic coefficient of
variance (GCV) for all the traits under study indicated the influence of
environment on expression of these traits. High heritability coupled with
high genetic advance as percent of mean suggested that direct selection for
the traits viz. iron content, test weight, calcium content, finger length,
protein content, flag leaf area and days to 80% maturity may be carried out
as these traits have preponderance of additive gene action. Similarly,
character association results depicted that direct selection for the traits
viz. flag leaf area, test weight, biological yield/plant, harvest index and
iron content will be effective for tangible advancement in grain yield of
this important millet. Further, Genetic divergence study for identifying
such promising genotypes revealed that among the seven clusters, Cluster III
and cluster VII were most divergent hence genotypes viz., MLS 1, MLS 5, GPU
67, VL 376 and Indira Ragi from these clusters may throw useful segregates
in upcoming generations.
Determination of the growth and yield traits of some mustard species under semi-arid central Anatolian conditions
Authors: Kayacetin Fatma , Aydin Oguzhan , Unal Sefa , Khawar Khalid
Published: March 2024

Brassica nigra, and B. juncea, are two economically important species that
are used as spices; and B. juncea, B. rapa ssp., oleifera, and B. nigra are
used for industrial seed oil. The potential of 16 Brassica genotypes?s
comparison with 2 standard varieties was done in terms of their phenology,
morphology, and yield performance under autumn-sown conditions during
2019-20 and 2020-21 under semi-arid climatic conditions of Central Anatolia,
in Ankara, T?rkiye. The experiment was performed in a randomized
complete-block design with four replications. The results indicated
statistically significant genotypes ? years interaction among all genotypes
for plant height, number of branches, number of pods, number of seeds,
1000-seed weight, seed yield, and crude oil yield of Brassica spp. Seed
emergence, rosette formation stage, 50% flowering, and 50% pod formation of
Brassica spp. varied according to species and years. While the maximum and
minimum crude oil yields of 1222 kg ha-1 were obtained from Standard 2 (B.
napus- Excalibur) and 313 kg ha-1 from the Bn4 genotype; the Br2 (1123 kg
ha-1), Br3 (1042 kg ha-1), Br6 (1093 kg ha-1), Br5 (949 kg ha-1) B. rapa
ssp., oleifera and Bj3 (893.3 kg ha-1) B. juncea genotypes appeared superior
in performance compared with the other genotypes. These genotypes can be
further exploited in various improvement programs through selection and
hybridization.
Intermittent Fasting–Improved Glucose Homeostasis Is Not Entirely Dependent on Caloric Restriction in db/db Male Mice
Authors: Zheng Dinghao , Hong Xiaosi , He Xiaodan , Lin Jianghong , Fan Shujin , Wu Jinli , Liang Zhuoxian , Chen Sifan , Yan Li , Ren Meng , Wang Wei
Published: March 2024

Intermittent fasting (IF), which involves prolonged fasting intervals accompanied by caloric restriction (CR), is an effective dietary treatment for obesity and diabetes. Although IF offers many benefits, it is difficult to determine whether these benefits are the consequences of CR. Every-other-day feeding (EODF) is a commonly used IF research model. This study was designed to identify factors, in addition to CR, responsible for the effects of EODF and the possible underlying mechanisms. Diabetic db/db mice were divided into three groups: ad libitum (AL), meal feeding (MF), and EODF. The MF model was used to attain a level of CR comparable to that of EODF, with food distribution evenly divided between 10:00 a.m. and 6:00 p.m., thereby minimizing the fasting interval. EODF yielded greater improvements in glucose homeostasis than MF in db/db mice by reducing fasting glucose levels and enhancing glucose tolerance. However, these effects on glucose metabolism were less pronounced in lean mice. Furthermore, ubiquitination of the liver-specific glucocorticoid (GC) receptor (GR) facilitated its degradation and downregulation of Kruppel-like factor 9 (KLF9), which ultimately suppressed liver gluconeogenesis in diabetic EODF mice. Although GR and KLF9 might mediate the metabolic benefits of EODF, the potential benefits of EODF might be limited by elevated serum GC levels in diabetic EODF mice. Overall, this study suggests that the metabolic benefits of EODF in improving glucose homeostasis are independent of CR, possibly because of the downstream effects of liver-specific GR degradation.

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