bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PELAKSANAAN SISTEM INFORMASI REKAM MEDIS BAGIAN PENDAFTARAN RAWAT JALAN DI RSUD PANEMBAHAN SENOPATI BANTUL TAHUN 2019
Authors: Jamroni  , Farizah
Published: November 2023

Background: Medical Record Information System is a very vital requirement for a medical institution. In order to speed up the provision of medical record information services to almost the entire hospital using the medical record information system including the Panembahan General Hospital, Senopati Bantul. Based on the results of a preliminary study conducted on the twenty-first of September 2018 on one of the patients who were waiting in the outpatient registration section with an average waiting time of 11.22 minutes, this complaint was confirmed by 2 other patients who were lining up with these patients.

Purpose: Analyze the Implementation of Medical Record Information Systems in the Outpatient Registration Section at Panembahan Senopati Hospital Bantul.

Method: This study uses qualitative research methods. This research was carried out by means of source triagulation techniques. This research was carried out in the Outpatient Registration section of Panembahan Senopati Hospital Bantul.

Results: The results of the study show that the Analysis of the Medical Record Information System Implementation in Outpatient Registration Section at Panembahan Senopati Hospital Bantul is human resources, facilities and infrastructure, software flow and hardware conditions.

Conclusion: Human resources, facilities and infrastructure, software flow and hardware conditions affected by network errors and applications that are down.
ANALISIS DEMPSTER SHAFER PADA SISTEM PAKAR PENDETEKSI PENYAKIT ISPA
Authors: Harliana  , Widayani Wiwi
Published: November 2023

ISPA is a serious disease that can occur in the community, even ISPA can also be the main killer of a baby's death. Symptoms caused by ISPA are almost the same as the symptoms of other diseases, so sometimes doctors or assistant doctors have difficulty diagnosing this disease. This study discusses the detection of ISPA through the dampstershafer method and the researchers will test the accuracy of the results obtained. Based on the test results through the matrix confusion of 100 patients and 13 types of ISPA, it produces an accuracy value of 95% with a 5% error rate and this is in accordance with the diagonosa produced by the doctor.
PROTOTYPE APLIKASI RECORDING TERNAK TERINTEGRASI DENGAN SISTEM IDENTIFIKASI DAN SERTIFIKASI TERNAK DI KABUPATEN KEBUMEN
Authors: Subagyo Untung
Published: November 2023

The Government of the Department of Agriculture and Food / Dinas Pertanian dan Pangan (Distapang) of Kebumen Regency has utilized information technology to register livestock and provide identity cards to livestock with the Livestock Card Database System. With this system, Distapang Kebumen can quickly find out the livestock population and household of farmers. Kebumen Regency is one of the best cattle breeding areas at the national level, namely for PO cattle. Therefore, the Agriculture and Food Service Office of Kebumen Regency provides a Breeding Certificate /Surat Keterangan Layak Bibit (SKLB) for livestock. SKLB will increase trust and satisfaction of livestock breed users, and will certainly increase the price of livestock. To make SKLB, Distapang uses the help of the SKLB Recording and Printing System ... Unfortunately, between the Livestock Card Database System and the SKLB Recording and Printing System is not integrated, so there is one job carried out by two officers, namely livestock data collection. Data on making livestock cards comes from forms filled out by data officers in the village area from livestock, while data recording comes from recording officers from members of the herd group / designated officers. The output of this research is in the form of an Android-based recording application prototype design, which is integrated with the Livestock Card Database System as an Identification System, and the SKLB Recording and Printing System as a System for Animal Certification
SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN SANTRI BARU TERAS TAHFIDZ DI TERAS DAKWAH MENGGUNAKAN METODE TOPSIS
Authors: PHS Yuli Praptomo , Destiana Selfia
Published: November 2023

This research was made to build a decision support system application for selecting new prospective students in the Teras Tahfidz. The methodology used in the decision support system process uses the TOPSIS (Technique For Others Reference by Similarity to Ideal Solution) method. It is hoped that this research can improve the quality of students enrolled later, and can make time efficient in selecting students. By using the Topsis Method, in this study a case will be raised, namely finding the best alternative based on predetermined criteria using the Topsis method. This method was chosen because it is able to select the best alternative. A number of alternatives, in this case the intended alternatives are new students of Teras Tahfidz who register based on specified criteria. The study was conducted by finding the value of the level of importance for each attribute, then carried out the process.
ANALISIS KETUNTASAN PEMBELAJARAN ONLINE PADA MATAKULIAH BAHASA INGGRIS
Authors: Faizal Edi , Sunardi Andhina Ika
Published: November 2023

The pandemic due to the corona virus at the end of 2019 (covid-19) has caused changes in the order of life, including education. Social and physical distancing in tackling the spread of Covid-19 affect the learning model. Starting from early childhood education to the university level applying an online learning model. This study analyzes the completeness of the online model of learning English. The analysis was carried out by using profile matching method on 430 student data from three universities in Yogyakarta. Completeness of learning is divided into 5 levels based on 4 components. The results showed that the level of completeness of online learning in all areas of higher education was 89.1%. The analysis of the results shows that the level of learning completeness of IT students is better than non-IT students, respectively 90.5% (IT) and 88.6% (Non-IT).
PERANCANGAN APLIKASI KLASIFIKASI SENTIMEN BERBASIS WEB TERHADAP MATA UANG KRIPTO
Authors: Sulaiman Fahmi Ilmawan , Winarno Wing Wahyu , Kurniawan Mei Parwanto
Published: November 2023

Sentiment analysis is a collection of opinions that studies opinions about something like an issue, product, event or topic. In deciding to choose cryptocurrency, the majority of Indonesian people tend to only read the latest reviews about cryptocurrencies and even a few will lead to wrong conclusions. To analyze cryptocurrency sentiment easily and quickly, a sentiment analysis system with a convenient and easy-to-use interface is required. The application to analyze this sentiment is web-based which is made using the PHP (Hypertext Preprocessor) framework by applying the MVC (Model View Controller) concept. This application can import data in CSV format which is then processed into an application using the nave Bayes algorithm in the sentiment classification process which is then evaluated by the confusion matrix method. The reviews are taken from social media twitter and it is hoped that this application will be able to provide classification information accurately, precisely and reliably.
Sistem Informasi E-Voting Pemilihan Ketua Badan Eksekutif Mahasiswa (BEM) STMIK El-Rahma Berbasis Web
Authors: Santoso Herdiesel
Published: November 2023

Pada masa pandemi covid 19, kemahasiswaan STMIK El Rahma menunda pemilihan umum ketua BEM karena pembatasan kegiatan di kampus. Peranan teknologi informasi diperlukan pada proses pemungutan suara agar pemilih dapat memberikan suaranya dimana saja tanpa harus datang ke tempat pemungutan suara. Tujuan penelitian adalah membuat sistem informasi e-voting pemilihan ketua Badan Eksekutif Mahasiswa (BEM) Stmik El-Rahma Berbasis Web. Metode penelitian yang digunakan adalah metode penelitian kualitatif dengan pendekatan studi kasus. Metodologi pengembangan perangkat lunak menggunakan metode System Development Life Cycle (SDLC), yang terdiri dari tahapan analisis kebutuhan sistem, desain sistem dan software, implementasi dan testing, serta evaluasi dan perbaikan  sistem. Hasil pengujian menggunakan back box testing  menunjukan bahwa tidak ditemukan adanya ketidak sesuaian fungsi input dan output  baik ketika dijalakankan pada perangkat web maupun  mobile
Sistem Informasi Manajemen Penelitian Dan Pengabdian Masyarakat menggunakan frame work Laravel di Stmik El Rahma
Authors: Sugiyatno  , Syafrianto Andri , Falahi Zilfana
Published: November 2023

SIMLITABMAS adalah Sistem Informasi Manajemen Penelitian dan Pengabdian Mayarakat. Dosen-dosen biasanya mengakses SIMLITABMAS dengan mengunjungi http://simlitabmas.ristekdikti.go.id/. Setiap dosen harus menerapkan Tridarma Perguruan Tinggi yang terdiri dari pengajaran, penelitian dan pengabdian. Maka dari itu SIMLITABMAS ini akan digunakan untuk mewadahi hasil dari kegiatan dosen dalam bidang penelitian dan pengabdian masyarakat. Sebenarnya, lebih luas lagi fungsinya, tapi secara umumnya begitu.Sistem Informasi Manajemen Penelitian dan Pengabdian Masyarakat STMIK El Rahma Yogyakarta, merupakan aplikasi web yang mengadopsi beberapa fungsi yang ada pada SIMLITABMAS milik kementrian dan dikti. Antara lain fungsi yang diadopsi adalah mewadahi hasil penelitian dan pengabdian dosen-dosen dalam lingkup Perguruan Tinggi STMIK El Rahma Yogyakarta, jadi sebelum hasil dari penelitian dan pengabdian masyarakat dikirimkan ke SIMLITABMAS milik kementrian dan dikti kita sudah lakukan seleksi lokal melalui sistem kita sendiri. Dengan adanya Sistem Informasi Manajemen Penelitian dan Pengabdian Masyarakat STMIK El Rahma Yogyakarta berbasis web ini, dapat memudahkan lembaga LPPM Perguruan Tinggi STMIK El Rahma dalam mewadahi, mengelola dan menyeleksi hasil Penelitian dan Pengabdian Masyarakat dosen-dosen STMIK El Rahma Yogyakarta sebelum dikirimkan ke SIMLITABMAS milik kementrian dan dikti.
Penerapan Metode CPI dan ROC untuk Penentuan Penempatan SDM
Authors: Subiyantoro Cuk , Sudarmanto
Published: November 2023

SDM berkualitas merupakan kekayaan tak ternilai bagi sebuah institusi, sehingga penempatan yang tepat akan meningkatkan produktifitas dan efektifitas pekerjaan. Prinsip The Right Man On The Right Place perlu mempertimbangkan kesesuaian antara posisi yang akan ditempati dengan kemampuan SDM yang akan menempatinya. Keputusan yang akan diambil oleh pengambil keputusan sedikit banyak akan dipengaruhi berbagai faktor diluar prinsip tersebut. Sehingga dibutuhkan sebuah sistem yang jelas dalam melakukan penempatan (positioning), salah satu alternatif dapat menggunakan sistem pendukung keputusan. Penelitian ini akan membahas tentang penerapan metode comparative performance index dengan pembobotan rank order centroid untuk penempatan sumberdaya manusia. Objek penelitian adalah pegawai yang berkerja pada Universitas Teknologi Digital Indonesia Yogyakarta. Hasil penelitian ini menghasilkan sebuah model pendukung keputusan yang dapat diimplementasikan guna dalam proses penempatan (positioning) sumberdaya manusia dengan tepat dan cepat.
Analisis Perbandingan Performasi Respon Waktu Web Server dan Failover Antara Kubernetes Dan Docker Swarm pada Container Orchestration
Authors: Sugiyatno  , M Ishak
Published: November 2023

Failover sebagai mekanisme dalam mengatasi single failure terintegrasi pada kubernetes dan docker swarm sebagai server cluster berbasis container atau orkestrasi container. Namun, perbedaan performansi failover dan respon waktu web server pada kubernetes dan docker swarm belum diketahui.

              Berangkat dari permasalahan tersebut, diperlukan suatu analisis yang mendalam terkait perbandingan performansi failover dan respon waktu web server antara kubernetes dan docker swarm dengan melakukan berbagai pengujian dan percobaan yang dilakukan pada masing-masing cluster tersebut.

Hasil pengujian dengan menggunakan percobaan upload file untuk mengetahui performansi respon waktu web server pada masing-masing cluster, ditemukan data bahwa respon waktu kubernetes 54,5% lebih cepat dibandingkan dengan docker swarm. Lalu pada pengujian failover dari sisi node failure, docker swarm memiliki waktu rata-rata failover yang sangat signifikan. Namun, docker swarm tidak memiliki management container seperti management pods yang terdapat pada kubernetes, sedangkan pada saat pengujian failover ketika proses upload file berlangsung, menampilkan bahwa kedua cluster memiliki hasil yang sama yaitu website mengalami error ketika pengujian dilakukan
Examining the Impact of Emotional Intelligence on Employee Well-Being and
Employee Engagement in the Digital Era
Authors: Pudasaini Thapa Pramila , Rana Hari , Ucar Özge , Khanal Josana , Amgain Kapil
Published: November 2023

Introduction: Employee Well-Being (EWB) and Employee Engagement (EE) are
crucial for a healthy workplace, but concern about Well-Being (WB) and EE
are still prevalent. Emotional intelligence (EI) can help regulate and
recognize emotions, and this study examines its impact on EWB and EE in the
Digital Era (DE), considering sociodemographic factors.Methods: This study
used a self-administered survey to gather the data and combined a
quantitative method with a descriptive cross-sectional research design. The
study made use of a variety of tools, including the employee engagement
scale (EES), which was used to assess EE, the emotional intelligence scale
(EIS), which was used to measure EI, and the functional well-being score
from the World Health Organization (WHO), which was used to measure EWB. All
the tools used in the study have been validated and are reliable, as
determined by Cronbach’s alpha and other statistical analysesResults: The
emotional intelligence (EI) significantly impacts employee well-being (EWB)
and employee engagement (EE). H1 was accepted through Pearson correlation (P
0.005, R = 0.065, R² = 0.004, and adjusted R² = 0.001), while H2 was
supported by regression analysis (P 0.005, R = 0.717, R² = 0.514, and
adjusted R² = 0.512). These findings highlight that EI is a predictor of EWB
and EE, as well as a factor associated with years of work
experience.Conclusion: The EI plays a crucial role in determining EWB and EE
and the association between EI and years of work experience. These results
imply that developing andenhancing EI competencies could positively impact
EWB and EE, thereby improving job satisfaction and organizational outcomes.
However, the study's limitations include a small sample size and a
cross-sectional design, which limits the generalizability of the
findings.
PENGGUNAAN METODE ROLE PLAYING UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS VII A PADA MATA PELAJARAN PAI AKHLAQ TERFUJI DI SMP NEGERI 9 TANJUNG JABUNG TIMUR
Authors: Masitah
Published: November 2023

Dalam proses pembelajaran anak kurang didorong untuk mengembangkan kemempuan berpikirnya. Penggunaaan strategi role playing akan meningkatkan pemahaman anak karena siswa sendiri yang memperagakan ahlak sesuai karakter yang dimainkan, maka secara tidak langsung siswa mengalami sendiri in diharapkan pembelajaran bisa bermakna bagi mereka. Hal inikarena proses pembelajaran yang monotondanmetodeatau modelpembelajaran yang kurang menarik maka peneliti tertarik untuk mengangkat judulPenggunaan Metode Role Playing Untuk meningkatkan hasil belajarPendidikan Agama Islam siswa kelas VII SMP Negeri Tanjung Jabung Timur .

Penelitian ini menggunakan jenis Penelitian Tindakan Kelas (classroom action research). Penelitian ini dilakukan secara kolaboratif dan partisipatif. Teknik pengambilan subjek dalam penelitian ini yakni mengggunakan purposive sampling. prosedur PTK dilaksanakan pada 4 kegiatan utama yaitu Plan (rencana), Action (tindakan), observation (pengamatan) dan reflection (refleksi). Sedangkan pengumpulan data, observasi,dan dokumentasi.Pada penelitian ini menggunakan dua siklus, yaitu setiap siklus terdiri dari dua kali pertemuan pada pertemuan kedua langsung mengadakan evaluasi dari pengunaan metode pembelajaran Role Playing.

Penelitian ini bisa diterima melihat penerapan metode Role Playing dapat meningkatkan hasil belajar siswa pada pembelajaran Pendidikan Agama Islam kelasVII . Hal ini dilihat dari hasil belajar yang meningkat yang awal pra-siklus 43,75% meningkat pada siklus I sebesar 65,62% dan siklus II 84,37%. Hasil penelitian ini menyarankan agar guru Pendidikan Agama Islam bisa menggunakan metode Role Playing demi meningkatkan hasil belajar siswa.
Electronic Communication and Publishing System for STI West Negros University Partner Communities
Authors: Tee Jay Andrew , Baylon Vanessa , Ang Fitz Gerald , Galanza Ceferino III , Bucao Winna
Published: November 2023

To address the evolving needs of community engagement in higher education, this research paper presents Konek, a web-based and mobile application designed to enhance community engagement for STI West Negros University's partner communities outside of Bacolod City. Konek addresses the challenges faced by the university's community extension office by providing a secure and centralized platform for partner community posts, events, and product dissemination. The system's features are carefully tailored to empower registered partner community and school department administrators while allowing users to interact with the content. The methodology for developing Konek involved utilizing a Development Research design to understand and address the university's community extension issues. The agile development methodology was employed throughout the project's lifecycle, ensuring flexibility and adaptability. Extensive evaluations were conducted to assess the system's reliability, efficiency, and user-friendliness. This innovative platform signifies a transformative solution for community engagement, laying the foundation for future enhancements.
Employee Attendance and Performance Monitoring System with Facial Recognition Technology and Data Analytics
Authors: Arreglado Marvin , Arreglado Henry II , Magante Vienna Nerianne , Lagrosa Kristine Joy , De Loyola Rhyan
Published: November 2023

Paper-based attendance monitoring is being altered daily, whether in public or private, making it unreliable in evaluating the authenticity of attendance. In a career context, attendance plays a fundamental role, and traditional methods for monitoring it need to be updated. The emergence of biometric identification, particularly facial recognition, offers a promising solution. This study introduces FRaDA, an employee data Analytics with a Face Recognition System developed explicitly for Talisay Elementary School (TES) faculty and staff. The system aims to digitize attendance monitoring and employee evaluation processes by leveraging facial recognition technology. It captures and records attendance via live camera feed, generates efficient performance and attendance reports, minimizes recording errors and tampering, automates Daily Time Records (DTR) generation, and facilitates intensive attendance management. The methodological approach follows the Agile Scrum model and involves Initialization, Planning and Estimating, Implementation, Review, and Releasing phases, ensuring a systematic and efficient development process. Key highlights include the evaluation process with an overall score of 3.00, indicating the project's feasibility and excellence. In conclusion, Project FRaDA offers a practical and efficient solution for attendance management and employee evaluation, addressing the limitations of traditional methods and meeting the institution's needs.
USABILITY OF VIRTUAL TOOLS FOR PARTICIPATORY ENTERPRISE MODELLING
Authors: Venter Anthea , de Vries Marne
Published: November 2023

Participatory modelling (PM) is focused on actively involving enterprise stakeholders and modelling experts in the modelling process. Typically, participants are co-located and encouraged to collaborate to avoid conceptual misalignment. During Covid-19, however, people were forced to reduce significantly their physical interactions, which led to the embracing of virtual tools. However, limited research has been done to evaluate virtual tools for the purpose of PM or participatory enterprise modelling (PEM), and specifically for the ease-of-use or usability of these tools. Many standardised usability questionnaires are available to evaluate the usability of user interfaces or systems. We provide key criteria for selecting an appropriate standardised questionnaire to measure PM tool usability and, as the main contribution, examine in a controlled experiment the usability of an online tool, MURAL, when participants use PEM. We report on the tool’s usability, using the selected standardised usability questionnaire, and present insights obtained through interviews and observations.
HETEROGENEOUS TRADING STRATEGY ENSEMBLING FOR INTRADAY TRADING ALGORITHMS
Authors: Koegelenberg Coetzee , van Vuuren Jan
Published: November 2023

Since the inception of algorithmic trading during the mid-1970s, considerable resources and time have been committed by the financial sector to the development of trading algorithms in the hope of obtaining a competitive advantage over human contenders. A plethora of trading algorithms has been proposed in the literature; each algorithm is unique in its design, but little emphasis has been placed on heterogeneous trading strategy ensembling. In this paper we propose a trading strategy ensemble method for combining three different domain-specific trading strategies: a deterministic strategy, a probabilistic strategy, and a machine-learning strategy. The objective of the trading strategy ensemble is to find an appropriate trade-off between the levels of return and the risk exposure of a trader. We implement our strategy across different historical forex currency pair data in a bid to validate the trading strategy ensemble, and we analyse the results by invoking appropriate return and risk performance measures.
ORGANISATIONAL ADAPTIVE LEADERSHIP FRAMEWORK THROUGH SYSTEMS THINKING
Authors: Abukalusa Khalid , Oosthuizen Rudolph
Published: November 2023

Leadership is a system that includes interconnected elements. Adaptive leadership is about enabling followers to handle adaptive challenges and to adapt to an ever-evolving environment. Organisations are experiencing the most dynamic era of the business environment owing to the influence of vulnerability, uncertainty, complexity, and ambiguity (VUCA). The VUCA nature of the environment presents adaptive challenges, which, unlike technical problems, need dynamic people-focused solutions. Current leadership frameworks are inadequate in practice, and a framework is needed to aid in creating adaptive organisations through systems thinking to succeed in a VUCA environment. This research approach starts with a systematic literature review to create a conceptual framework of adaptive leadership through systems thinking for a VUCA environment. The conceptual framework is validated through interviews with practising industry leaders to obtain their opinions and comments. The research provides a new perspective on using systems thinking in applying leadership practices to create an adaptive leadership framework to overcome the VUCA environment.
SOCIO-TECHNICAL SYSTEMS: USING ACTOR-NETWORK THEORY TO MAKE THE SOCIAL MORE TANGIBLE IN A TECHNICAL SPACE
Authors: Gumede Nosipho , Tladi Bontle
Published: November 2023

In technical spaces, the social can be seen as incidental (a distant factor to be monitored for avoidable negative impact), inaccessible (something to be assigned to someone with specialised skills), and implausible (involving wicked problems and improbable resolution). As a result, the social aspects of technical effort can be managed separately, haphazardly, without a common language, and outside of recognisable processes and transferable skills. This paper positions the social and technical as interconnected. It applies a systematic literature review to extend actor-network theory. The study offers language and a method to make the social aspects of technical work more describable, accessible, and systematic. It provides a framework for engineering practitioners to describe, analyse, and design socio-technical systems.
THE DEVELOPMENT OF AN ACTION PRIORITY MATRIX AND TECHNOLOGY ROADMAP FOR THE IMPLEMENTATION OF DATA-DRIVEN AND MACHINE-LEARNING-BASED PREDICTIVE MAINTENANCE IN THE SOUTH AFRICAN RAILWAY INDUSTRY
Authors: Nethamba Lindelani , Grobbelaar Schalk
Published: November 2023

In improving railways for the future, artificial intelligence and machine learning were identified as top-priority technology systems that enable data-driven methods and predictive maintenance. A local survey using semi-structured interviews showed that the railway industry lags behind in adopting and implementing data-driven and machine-learning methods for predictive maintenance. Insights from international studies were found to be relevant in South Africa. Other implementation barriers were identified in the socio-economic and socio-political areas of South Africa. An action priority matrix and technology roadmap was developed to guide the South African railway industry towards the implementation of data-driven and machine learning-based predictive maintenance. The action priority matrix was developed by using a two-round Delphi technique to rank the prioritisation of the required activities. The research showed the importance of considering insights from both international studies and the local context when adopting and implementing technology systems to improve business objectives.
Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
Authors: Ober Veronica Teresa , Githure George Boniface , Volpato Santos Yuri , Becker Sidney , Moya Munoz Gabriel , Basquin Jérôme , Schwede Frank , Lorentzen Esben , Boshart Michael
Published: November 2023

Cyclic nucleotide binding domains (CNB) confer allosteric regulation by cAMP or cGMP to many signaling proteins, including PKA and PKG. PKA of phylogenetically distant Trypanosoma is the first exception as it is cyclic nucleotide-independent and responsive to nucleoside analogues (Bachmaier et al., 2019). Here, we show that natural nucleosides inosine, guanosine and adenosine are nanomolar affinity CNB ligands and activators of PKA orthologs of the important tropical pathogens Trypanosoma brucei, Trypanosoma cruzi, and Leishmania. The sequence and structural determinants of binding affinity, -specificity and kinase activation of PKAR were established by structure-activity relationship (SAR) analysis, co-crystal structures and mutagenesis. Substitution of two to three amino acids in the binding sites is sufficient for conversion of CNB domains from nucleoside to cyclic nucleotide specificity. In addition, a trypanosomatid-specific C-terminal helix (αD) is required for high affinity binding to CNB-B. The αD helix functions as a lid of the binding site that shields ligands from solvent. Selectivity of guanosine for CNB-B and of adenosine for CNB-A results in synergistic kinase activation at low nanomolar concentration. PKA pulldown from rapid lysis establishes guanosine as the predominant ligand in vivo in T. brucei bloodstream forms, whereas guanosine and adenosine seem to synergize in the procyclic developmental stage in the insect vector. We discuss the versatile use of CNB domains in evolution and recruitment of PKA for novel nucleoside-mediated signaling.
Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity
Authors: Kirchhofer Sina B , Lim Victor Jun Yu , Ernst Sebastian , Karsai Noemi , Ruland Julia G , Canals Meritxell , Kolb Peter , Bünemann Moritz
Published: November 2023

The µ opioid receptor (MOR) is the key target for analgesia, but the application of opioids is accompanied by several issues. There is a wide range of opioid analgesics, differing in their chemical structure and their properties of receptor activation and subsequent effects. A better understanding of ligand-receptor interactions and the resulting effects is important. Here, we calculated the respective binding poses for several opioids and analyzed interaction fingerprints between ligand and receptor. We further corroborated the interactions experimentally by cellular assays. As MOR was observed to display ligand-induced modulation of activity due to changes in membrane potential, we further analyzed the effects of voltage sensitivity on this receptor. Combining in silico and in vitro approaches, we defined discriminating interaction patterns responsible for ligand-specific voltage sensitivity and present new insights into their specific effects on activation of the MOR.
PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum
Authors: Chahine Zeinab M , Gupta Mohit , Lenz Todd , Hollin Thomas , Abel Steven , Banks Charles , Saraf Anita , Prudhomme Jacques , Bhanvadia Suhani , Florens Laurence A , Le Roch Karine G
Published: November 2023

The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regulation. Microrchidia (MORC) proteins have been implicated in DNA compaction and gene silencing across plant and animal kingdoms. Accumulating evidence has shed light on the role MORC protein plays as a transcriptional switch in apicomplexan parasites. In this study, using the CRISPR/Cas9 genome editing tool along with complementary molecular and genomics approaches, we demonstrate that PfMORC not only modulates chromatin structure and heterochromatin formation throughout the parasite erythrocytic cycle, but is also essential to the parasite survival. Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) experiments suggests that PfMORC binds to not only sub-telomeric regions and genes involved in antigenic variation but may also play a role in modulating stage transition. Protein knockdown experiments followed by chromatin conformation capture (Hi-C) studies indicate that downregulation of PfMORC impairs key histone marks and induces the collapse of the parasite heterochromatin structure leading to its death. All together these findings confirm that PfMORC plays a crucial role in chromatin structure and gene regulation, validating this factor as a strong candidate for novel antimalarial strategies.
Grøntproduksjon i nord
Authors: Hykkerud Anne Linn , Gillund Frøydis , Elverland Ellen , Halland Hilde , Johansen Tor Jacob , Mølmann Jørgen
Published: November 2023

Til tross for den korte vekstsesongen i Nord-Norge er det lange tradisjoner for produksjon av både poteter og flere av våre velkjente grønnsaks- og bærarter.  Forskere på Holt i Tromsø har blant annet undersøkt hvilke sorter som egner seg for dyrking i nord og den særegne nordnorske kvaliteten. De siste årene har bærekraft i grøntproduksjonen også fått økt oppmerksomhet.
Quantifying the land and population risk of sewage spills overland using a fine-scale, DEM-based GIS model
Authors: McDaniel Emma L. , Atkinson Samuel F. , Tiwari Chetan
Published: November 2023

Accidental releases of untreated sewage into the environment, known as sewage spills, may cause adverse gastrointestinal stress to exposed populations, especially in young, elderly, or immune-compromised individuals. In addition to human pathogens, untreated sewage contains high levels of micropollutants, organic matter, nitrogen, and phosphorus, potentially resulting in aquatic ecosystem impacts such as algal blooms, depleted oxygen, and fish kills in spill-impacted waterways. Our Geographic Information System (GIS) model, Spill Footprint Exposure Risk (SFER) integrates fine-scale elevation data (1/3 arc-second) with flowpath tracing methods to estimate the expected overland pathways of sewage spills and the locations where they are likely to pool. The SFER model can be integrated with secondary measures tailored to the unique needs of decision-makers so they can assess spatially potential exposure risk. To illustrate avenues to assess risk, we developed risk measures for land and population health. The land risk of sewage spills is calculated for subwatershed regions by computing the proportion of the subwatershed’s area that is affected by one modeled footprint. The population health risk is assessed by computing the estimated number of individuals who are within the modeled footprint using fine-scale (90 square meters) population estimates data from LandScan USA. In the results, with a focus on the Atlanta metropolitan region, potential strategies to combine these risk measures with the SFER model are outlined to identify specific areas for intervention.
Insight from the association between critical thinking and English argumentative writing: catering to English learners’ writing ability
Authors: Hu Yanfang , Saleem Atif
Published: November 2023

Introduction

English argumentative writing (EAW) is a ‘problem-solving’ cognitive process, and its relationship with critical thinking has drawn attention in China. This is because fostering EAW proficiency is a crucial element but a challenging task for Chinese high school English teaching and learning. The present study examined how critical thinking is related to Chinese high school students’ EAW performance. The study identified eight critical thinking disposition (CTD) subscales and aims to determine whether EAW and CTD are correlated.

Methods

A questionnaire modified from the Chinese Version Critical Thinking Disposition Inventory (CTDI-CV) and the Evaluation Criteria for English Argumentative Writing (ECEAW) were employed in this study. Both instruments were administered to 156 students from Grade 12. A purposive sampling of high school students was used in this study. Student EAW performance was scored by two experts based on the Evaluation Criteria for English Argumentative Writing.

Results

A significant relationship was found between students’ CTD and EAW abilities. Furthermore, among the eight CTD subdispositions, cognitive maturity, truth-seeking, analyticity, and justice were found to be positively correlated with EAW, and they all were found to be the main predictors of EAW proficiency among high school students.

Conclusion

Zhangzhou high school students’ CTDs were overall positive, and students’ EAW performance correlated significantly with the overall CTD and its four subdispositions of cognitive maturity, truth-seeking, analyticity, and justice. These four subdispositions showed a significantly predictive validity on EAW performance as well.
Genome-wide identification of 2-oxoglutarate and Fe (II)-dependent dioxygenase family genes and their expression profiling under drought and salt stress in potato
Authors: Chauhan Hanny , Aiana  , Singh Kashmir
Published: November 2023

The 2-Oxoglutatrate-dependent dioxygenases (2OGDs) comprise the 2-Oxoglutatrate and Fe(II)-dependent dioxygenases (2ODD) enzyme families that facilitate the biosynthesis of various compounds like gibberellin, ethylene,etc. The2OGDsare also involved in various catabolism pathways, such as auxin and salicylic acid catabolism. Despite their important roles,2ODDshave not been studied in potato, which is the third most important crop globally. In this study, a comprehensive genome wide analysis was done to identify all2ODDsin potatoes, and the putative genes were analysed for the presence of the signature 2OG-FeII_Oxy (PF03171) domain and the conserved DIOX_N (PF14226) domain. A total of 205St2ODDswere identified and classified into eight groups based on their function. The physiochemical properties, gene structures, and motifs were analysed, and gene duplication events were also searched forSt2ODDs. The active amino acid residues responsible for binding with 2-oxoglutarate and Fe (II) were conserved throughout theSt2ODDs. The three-dimensional (3D) structures of the representative members of flavanol synthase (FNS), 1-aminocyclopropane-1-carboxylic acid oxidases (ACOs), and gibberellin oxidases (GAOXs) were made and docked with their respective substrates, and the potential interactions were visualised. The expression patterns of theSt2ODDsunder abiotic stressors such as heat, salt, and drought were also analysed. We found altered expression levels ofSt2ODDsunder abiotic stress conditions, which was further confirmed for drought and salt stress using qRT-PCR. The expression levels ofSt2ODD115,St2ODD34, andSt2ODD99were found to be upregulated in drought stress with 2.2, 1.8, and 2.6 fold changes, respectively. After rewatering, the expression levels were normal. In salt stress, the expression levels ofSt2ODD151,St2ODD76,St2ODD91, andSt2ODD34were found to be upregulated after 24 hours (h), 48 hours (h), 72 hours (h), and 96 hours (h). Altogether, the elevated expression levels suggest the importance ofSt2ODDsunder abiotic stresses,i.e., drought and salt. Overall, our study provided a knowledge base for the2ODDgene family in potato, which can be used further to study the important roles of2ODDsin potato plants.
MÃ¡s AllÃ¡ de la Sensibilidad Materna: Modelo Predictivo de la Calidad del Apego
Authors: Lecannelier Felipe , Guajardo Humberto , Monje-Ojeda GermÃ¡n
Published: November 2023

El estudio del apego de los bebÃ©s con sus madres es objeto de las ciencias mÃ©dicas y sociales, investigÃ¡ndose desde la actividad genÃ©tica hasta los efectos de la cultura. Como parte de la gran diversidad de estudios, una problemÃ¡tica de investigaciÃ³n fundamental es comprender si y cÃ³mo las conductas maternales influyen en el desarrollo de la calidad y tipo de apego del infante. En la actualidad, las propuestas han sido muy generales, no pudiÃ©ndose evidenciar modelos predictivos significativos. El presente estudio analiza si un modelo especÃ­fico de conductas maternales puede predecir la calidad y patrÃ³n de apego durante los primeros dos aÃ±os de vida del bebÃ©, controlando la salud mental de ambos, a travÃ©s de una metodologÃ­a microobservacional experimental. Se evaluÃ³ a 103 madres y sus infantes (de 15 a 20 meses) a travÃ©s de dos procedimientos de microobservaciÃ³n: situaciÃ³n extraÃ±a y AMBIANCE. Se utilizÃ³ un modelo de regresiÃ³n logÃ­stica multinomial para verificar el modelo propuesto. Los resultados indican que el comportamiento materno, relacionado con errores comunicacionales, podrÃ­an predecir tanto la calidad como el tipo de apego del infante, controlando la salud mental de la madre y el niÃ±o ya que en el 71,5% de los casos, los errores comunicativos explicarÃ­an la varianza del apego infantil desarrollado (r2 de Nagelkerke = 0,715); p < 0,001). Este modelo puede ser una avenida prometedora para la elaboraciÃ³n de programas preventivos en salud mental infantil. El presente estudio es el primero realizado en LatinoamÃ©rica bajo este tipo de metodologÃ­a microanalÃ­tica.
Predictores de las Conductas de Autocuidado para Prevenir el Contagio de COVID-19 en Chile
Authors: Salazar-FernÃ¡ndez Camila , Baeza-Rivera MarÃ­a JosÃ© , ManrÃ­quez-Robles Diego , Aedo Melisa , Toro BÃ¡rbara
Published: November 2023

La pandemia por la COVID-19 se ha transformado en la principal crisis epidemiolÃ³gica del siglo, por lo que debieron adoptarse diversas conductas de autocuidado. La eficacia de estas estrategias preventivas depende de la adherencia que mantenga la poblaciÃ³n. El objetivo de este estudio fue establecer los predictores de la adherencia a las conductas de autocuidado para la prevenciÃ³n del contagio de la COVID-19 en poblaciÃ³n chilena mayor a 18 aÃ±os. Una muestra no probabilÃ­stica de 1.033 personas respondiÃ³ un cuestionario virtual, bajo un diseÃ±o transversal. Se emplearon escalas de autoreporte sobre percepciÃ³n de riesgo, normas procuidado y conductas de autocuidado contra la COVID-19. Utilizando regresiones mÃºltiples jerÃ¡rquicas, se encontrÃ³ que el gÃ©nero, percepciÃ³n de riesgo y normas procuidado contra la COVID-19 predijeron significativa y directamente el uso de mascarilla, conductas de higiene y distancia social, mientras que la edad solo predijo mayor adhesiÃ³n a conductas de higiene y el estatus socioeconÃ³mico solo predijo el uso de mascarilla y distancia social. En todas las conductas de autocuidado la interacciÃ³n entre percepciÃ³n de riesgo y normas procuidado sugiere que a niveles bajos de norma procuidado, la percepciÃ³n de riesgo potencia la adopciÃ³n de estas conductas. A partir de estos hallazgos, se sugiere elaborar estrategias que promuevan conductas de autocuidado con base en la percepciÃ³n de riesgo, considerando variables como el gÃ©nero, edad y estatus socioeconÃ³mico, a travÃ©s de la creaciÃ³n y mantenciÃ³n de normas procuidado que consideren las relaciones entre el individuo y otros significativos en la percepciÃ³n de la valoraciÃ³n positiva de sus conductas en salud.
In situ measurements of carbonation rate with air permeability for the development of a proposal for a classification of exposure to carbonation.
Authors: Ebensperger M. Luis , Olivares O. Mario
Published: November 2023

The ingress of carbon dioxide CO2 into concrete is an issue that, unfortunately, does not have sufficient precedents at the national level for the execution of the Residual Service Life analysis of concrete structures. As a precursor element of steel corrosion, it is necessary to count on information on the behavior that concrete could have in Chile, according to the levels of aggressiveness expected for specific project locations. It was only in 2016 that the NCh170 Concrete Standard included this type of Exposure with Grade C1 as Mild Aggressiveness. This work presents a review of background information collected from various third-party and own works, along with measurements of Carbonation Rates in 20-year-old concretes made in the city of Santiago, relating them to Air Permeability measured in a non-destructive way, which allowed generating a proposal for the Classification of the Degree of Exposure to Carbonation.
High-Cadence Stellar Variability Studies of Galactic RR Lyrae Stars with DECam
Authors:   , Baeza Villagra Karina
Published: November 2023

As part of the DECam Alliance for Transients (DECAT), a consortium of time- domain DECam programs, the DECam Deep Drilling Program (DDP) is being conducted at the Blanco 4m telescope, located at Cerro Tololo Inter-American Observatory, Chile. The DDP includes the DECaPS East field, situated in the Galactic bulge at coordinates (RA, DEC)(J2000) = (18:03:34, -29:32:02). We performed two nights of high-cadence, multi- band (griz) observations utilizing DECam. We obtained high-quality griz light curves for 1033 previously identified RR Lyrae stars. Subsequently, a robust Fourier decomposition analysis was con- ducted, generating well-defined, multi-band light curve templates for 143 RRab and 146 RRc stars. This process aimed to update and enhance the existing RR Lyrae star templates catalog. Therefore, our work is expected to broadly apply to the data acquired from the Vera C. Rubin Observatory’s Legacy Survey of Space and Time. Furthermore, we compared and analyzed the dependence of Fourier coef- ficients and other derived light curve parameters on the effective wavelength, providing valuable in-sights into the behavior and structure of RR Lyrae stars. Another significant contribution of this study was the construction of the Period- φ31-[Fe/H] relations, total-to-selective extinction ratios, and distances for each star in both the DECam and Sloan photometric systems. This information is crucial for investigating RR Lyrae stars and their role as tracers of Galactic structures. By combining these results, we better un- derstand the characteristics and morphology of their light curves, the chemical composition through studying their metallicities, and the spatial distribution of RR Lyrae stars within the Galactic bulge. This knowledge contributes to the overall effort of classifying and detecting variable stars.
Léxico disponible de estudiantes universitarios de Educación Básica y Letras Hispánicas: un estudio sociolingüístico comparativo y análisis de técnicas de recolección de datos
Authors:   , Martínez Lara José Alejandro
Published: November 2023

Esta tesis doctoral examina el léxico disponible (en adelante LD) –es decir, el conjunto de palabras que viene más rápido a la mente cuando se activa un tema específico a través de un estímulo verbal (Michéa, 1953; Gougenheim et al., 1964; López Morales, 1995-1996; Gómez Molina, 2021, entre otros) – referido a los centros de interés (CI) 01. La lectura, 02. El profesor, 03. La educación, 04. Juegos y distracciones, 05. La escuela, 06. Habilidades docentes, 07. Partes del cuerpo y 08. Comidas y bebidas, de universitarios de Educación Básica (EB) y Letras Hispánicas (LH) de la Pontificia Universidad Católica de Chile. Con base en este tema, el objetivo de esta investigación es conocer cuánto y cuál es el LD, recolectado tanto en formato papel como digital, con la finalidad de determinar, a través de análisis comparativos, las convergencias y divergencias de los lexicones de los estudiantes de EB y LH, así como evaluar la técnica alternativa de recogida de datos a través de un instrumento electrónico. Para esto, se examinó, cuantitativa y cualitativamente, un corpus producido por 264 participantes, organizado en tres muestras: 1) Educación Básica; 2) Letras Hispánicas, estas dos fueron recogidas a través de instrumentos en papel; y 3) Letras Hispánicas, colectada mediante la página web ad hoc. Los resultados cuantitativos generales indican que los CI más productivos, ricos y compactos son ‒ordenados según sus respectivos rangos‒ el 07, 08 y 05. En tanto que los análisis inferenciales señalan que son significativas las relaciones entre Sexo y el CI05, así como Año de curso y CI08, a favor de las variantes mujeres y 1.er Año, respectivamente. En cuanto a la variable Carrera, específicamente, debe destacarse que las medias globales de LH (19,71) y EB (16,51) se diferencian por 3,2 puntos, y muestra una significancia de p = 000 en el CI01, siendo las palabras más disponibles: libro, letra, leer, autor y palabra. Por su parte, la variable Formato de pruebas exhibe promedios de palabras globales, entre la muestra en papel (19,71) y la digital (19,23), bastante similares, con una distinción de apenas 0,48 lexías. Asimismo, se aprecia una significación del factor en el CI06 (p = 0,32); los vocablos más disponibles de este grupo son: empatía, comprensión, vocación, paciencia y enseñar. Por último, al analizar los grafos del CI01, se determinó que los tres grupos presentan asociaciones semánticas parecidas, en las que se evidencian los recursos de meronimia, afinidad semántica y proximidad visual. En conclusión, los análisis, cuantitativos y cualitativos, han permitido demostrar que existen diferencias léxico-métricas significativas entre las comunidades discursivas (Parodi, 2004; Bolívar, 2013). Asimismo, se ha logrado evaluar un instrumento digital que puede recoger datos léxicos de manera acertada, por lo que debe ahondarse más sobre este tópico.