bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Preparation and Properties of Intrinsic Super-Hydrophobic Foamed Magnesium Oxychloride Cement Material
Authors: Huang Jiaxin , Ge Shaojin , Wang Hongning , Chen Ruoyu
Published: November 2020

As we all know, magnesium oxychloride foamed cement material has poor water resistance, leading to a decline in application value. In our research, tetraethylorthosilicate (TEOS) and triethoxy-1H, 1H, 2H, 2H-tridecylfluoro-n-octylsilane (FAS) were pre-cohydrolyzed to prepare the overall super hydrophobic magnesium oxychloride cement (MOC) foamed material, and its structure and performances were systematically studied. The results show that adding organosilane can make it have overall hydrophobicity under the premise of maintaining the compressive strength. Mechanical abrading and chemical corrosion tests show its good engineering durability. The maximum moisture absorption rate dropped by 16.2%, and the quality can be restored to 98.1% of the original quality after dehumidification. All these properties show that the hydrophobic foamed magnesium oxychloride cement has potential engineering application value.
Analysis of Spatial Data from Moss Biomonitoring in Czech–Polish Border
Authors: Svozilíková Krakovská Aneta , Svozilík Vladislav , Zinicovscaia Inga , Vergel Konstantin , Jančík Petr
Published: November 2020

The purpose of the study was the analysis of spatial data gained by biomonitoring with the use of mosses. A partial goal was set to characterize the regional atmospheric deposition of pollutants in the air based on the results of the analyses and simultaneously verify the suitability of using mosses as an alternative for monitoring air quality in smaller industrial areas. In total, 93 samples of moss were collected and examined from the area of the Moravian–Silesian Region in the Czech Republic and the area of the Silesian Voivodship in Poland. The samples were analyzed using instrumental neutron activation analysis. Based on the analyses performed, 38 elements, which had been evaluated using principal component analysis, hierarchical clustering on principal components, factor analysis, correlation analysis, contamination factor, geoaccumulation index, enrichment factor, and pollution load index, were determined. The analyses resulted in a division of elements into a group with its concentrations close to the level of the values of the natural background and the second group of elements identified as emission likely originating from anthropogenic activity (Sm, W, U, Tb, and Th). The likely dominant source of emissions for the studied area was identified. Simultaneously, the results pointed to sources of local importance. The area of interest was divided into clusters according to the prevailing type of pollution and long-distance transmission of pollutants was confirmed.
Management of Antiphospholipid Syndrome
Authors: Ghembaza Amine , Saadoun David
Published: November 2020

Antiphospholipid syndrome (APS), is an acquired autoimmune disorder characterised by thrombosis, pregnancy morbidity, and the presence of antiphospholipid antibodies (aPL). Although venous thromboembolism is the most common manifestation, thrombotic events in APS may also occur in virtually any vascular bed, with cerebral circulation being the arterial territory most commonly affected. As APS is a heterogeneous condition, its management should be tailored with a patient-centred approach based on individual risk assessment, which includes the aPL profile, concomitant auto-immune diseases, and traditional cardiovascular risk factors. Although literature data are conflicting regarding primary prophylaxis, there is some evidence indicating that antiplatelet agents may reduce the risk of a first thrombotic event in individuals with a high-risk profile. In patients with thrombotic APS, current evidence-based guidelines recommend lifelong vitamin K antagonists (VKAs), preferably warfarin. The optimal intensity of anticoagulation following arterial thrombosis remains controversial. Arterial thrombosis should be treated either with high-intensity warfarin at a target INR > 3.0, or low-dose aspirin (LDA) combined with moderate-intensity warfarin (INR 2.0–3.0). It is recommended to avoid direct oral anticoagulants (DOACs) in patients with high-risk APS, mainly those with triple-positive PL and previous arterial events. They would only be used exceptionally in selected patients with low-risk venous thromboembolism (VTE). In low-risk VTE patients currently treated with a DOAC due to warfarin intolerance or a previous unstable International Normalized Ratio on warfarin, the decision of continuing DOACs would be taken in carefully selected patients. In women with obstetric APS, the combination therapy with LDA plus heparin remains the conventional strategy.
Early Depression Independently of Other Neuropsychiatric Conditions, Influences Disability and Mortality after Stroke (Research Study—Part of PROPOLIS Study)
Authors: Kowalska Katarzyna , Krzywoszański Łukasz , Droś Jakub , Pasińska Paulina , Wilk Aleksander , Klimkowicz-Mrowiec Aleksandra
Published: November 2020

Post-stroke depression (PSD) is the most frequent neuropsychiatric consequence of stroke. The nature of the relationship between PSD and mortality still remains unknown. One hypothesis is that PSD could be more frequent in those patients who are more vulnerable to physical disability, a mediator variable for higher level of physical damage related to higher risk of mortality. Therefore, the authors’ objective was to explore the assumption that PSD increases disability after stroke, and secondly, that mortality is higher among patients with PSD regardless of stroke severity and other neuropsychiatric conditions. We included 524 consecutive patients with acute stroke or transient ischemic attack, who were screened for depression between 7–10 days after stroke onset. Physical impairment and death were the outcomes measures at evaluation check points three and 12 months post-stroke. PSD independently increased the level of disability three (OR = 1.94, 95% CI 1.31–2.87, p = 0.001), and 12 months post-stroke (OR = 1.61, 95% CI 1.14–2.48, p = 0.009). PSD was also an independent risk factor for death three (OR = 5.68, 95% CI 1.58–20.37, p = 0.008) and 12 months after stroke (OR = 4.53, 95% CI 2.06–9.94, p = 0.001). Our study shows the negative impact of early PSD on the level of disability and survival rates during first year after stroke and supports the assumption that depression may act as an independent mediator for disability leading to death in patients who are more vulnerable for brain injury.
Improved Weathering Performance of Poly(Lactic Acid) through Carbon Nanotubes Addition: Thermal, Microstructural, and Nanomechanical Analyses
Authors: Vu Thevu , Nikaeen Peyman , Chirdon William , Khattab Ahmed , Depan Dilip
Published: November 2020

To understand the interrelationship between the microstructure and degradation behavior of poly(lactic acid) (PLA), single-walled carbon nanotubes (CNTs) were introduced into PLA as nucleating agents. The degradation behavior of PLA-CNT nanocomposites was examined under accelerated weathering conditions with exposure to UV light, heat, and moisture. The degradation mechanism proceeded via the Norrish type II mechanism of carbonyl polyester. Differential scanning calorimetry (DSC) studies showed an increase in glass transition temperature, melting temperature, and crystallinity as a result of the degradation. However, pure PLA showed higher degradation as evidenced by increased crystallinity, lower onset decomposition temperature, embrittlement, and a higher number of micro-voids which became broader and deeper during degradation. In the PLA-CNT nanocomposites, CNTs created a tortuous pathway which inhibits the penetration of water molecules deeper into the polymer matrix, making PLA thermally stable by increasing the initial temperature of mass loss. CNTs appear to retard PLA degradation by impeding mass transfer. Our study will facilitate designing environmentally friendly packaging materials that display greater resistance to degradation in the presence of moisture and UV light.
Oncogenes in Cancer: Using the Problem as Part of the Solution
Authors: Gil-Bazo Ignacio
Published: November 2020

Human cancer is considered to have a multifactorial origin [...]
The Prognostic Role of the Surgical Margins in Squamous Vulvar Cancer: A Retrospective Australian Study
Authors: Barlow Ellen L. , Jackson Michael , Hacker Neville F.
Published: November 2020

For the last 30 years at the Royal Hospital for Women, unifocal vulvar squamous cancers have been treated by radical local excision, aiming to achieve a histopathological margin of ≥8 mm, equating to a surgical margin of 1 cm. The need for a margin of this width has recently been challenged. We aimed to determine the long-term outcome following this conservative approach, and the relationship between vulvar recurrences and surgical margins. Data were obtained retrospectively on 345 patients treated primarily with surgery for squamous vulvar cancer between 1987 and 2017. Median follow-up was 93 months. Five-year disease-specific survival was 86%. Of 78 vulvar recurrences, 33 (42.3%) were at the primary site and 45 (57.7%) at a remote site. In multivariable analysis, a margin < 5 mm showed a higher risk of all vulvar (Hazard ratio (HR), 2.29; CI, 1.12−4.70), and primary site recurrences (subdistribution hazard ratio (SHR), 15.20; CI, 5.21−44.26), while those with a margin of 5 to <8 mm had a higher risk of a primary site recurrence (SHR, 8.92; CI, 3.26−24.43), and a lower risk of remote site recurrence. Excision margins < 8 mm treated by re-excision or radiation therapy had a significantly decreased risk of recurrence. Guidelines should continue to recommend a surgical margin of 1 cm.
Cancer-Associated Angiogenesis: The Endothelial Cell as a Checkpoint for Immunological Patrolling
Authors: Solimando Antonio Giovanni , Summa Simona De , Vacca Angelo , Ribatti Domenico
Published: November 2020

Cancer-associated neo vessels’ formation acts as a gatekeeper that orchestrates the entrance and egress of patrolling immune cells within the tumor milieu. This is achieved, in part, via the directed chemokines’ expression and cell adhesion molecules on the endothelial cell surface that attract and retain circulating leukocytes. The crosstalk between adaptive immune cells and the cancer endothelium is thus essential for tumor immune surveillance and the success of immune-based therapies that harness immune cells to kill tumor cells. This review will focus on the biology of the endothelium and will explore the vascular-specific molecular mediators that control the recruitment, retention, and trafficking of immune cells that are essential for effective antitumor immunity. The literature revision will also explore how abnormalities in the tumor endothelium impair crosstalk with adaptive immune cells and how targeting these abnormalities can improve the success of immune-based therapies for different malignancies, with a particular focus on the paradigmatic example represented by multiple myeloma. We also generated and provide two original bio-informatic analyses, in order to sketch the physiopathology underlying the endothelial–neoplastic interactions in an easier manner, feeding into a vicious cycle propagating disease progression and highlighting novel pathways that might be exploited therapeutically.
Outcome of Targeted Therapy Recommendations for Metastatic and Recurrent Head and Neck Cancers
Authors: Taghizadeh Hossein , Mader Robert M. , Müllauer Leonhard , Fuereder Thorsten , Kautzky-Willer Alexandra , Prager Gerald W.
Published: November 2020

Recurrent/metastatic (R/M) head and neck cancers bear a poor prognosis. In this analysis, we examined the efficacy and the outcome of targeted therapy recommendations based on the patients’ molecular tumor portrait after failure of all standard therapy options. In this single-center, real-world retrospective analysis of our platform for precision medicine, we analyzed the molecular profile of 50 patients diagnosed with R/M head and neck cancer. Tumor samples of the patients were examined using next-generation sequencing panels of mutation hotspots, microsatellite instability (MSI) testing, and immunohistochemistry (IHC). In 31 cases (62.0% of all patients), a molecular-driven targeted therapy approach was recommended. Eventually, 14 patients (28%) received the suggested targeted therapy. Six of fourteen patients (43%) achieved stable disease conditions and four patients (29%) experienced a progressive disease. The median time to treatment failure was 2.8 months. Therapy recommendations were significantly more often issued for men (p = 0.037) than for women. This analysis demonstrated that precision medicine provided the basis for molecular-driven therapy recommendations in over half of the patients with advanced therapy refractory head and neck cancers, with significantly more therapy recommendations for men. Our analysis showed that although precision medicine approaches are implementable and feasible for the management of recurrent/metastatic head and neck cancers in daily clinical routine, there are major limitations and challenges that have to be overcome.
Cancer and Immune Checkpoint Inhibitor Treatment in the Era of SARS-CoV-2 Infection
Authors: Gambichler Thilo , Reuther Judith , Scheel Christina H. , Susok Laura , Kern Peter , Becker Jürgen C.
Published: November 2020

Whether cancer patients receiving immune checkpoint inhibitors (ICI) are at an increased risk of severe infection and mortality during the corona pandemic is a hotly debated topic that will continue to evolve. Here, we summarize and discuss current studies regarding COVID-19 and anti-cancer treatment with an emphasis on ICI. Importantly, several lines of evidence suggest that patients currently treated with ICI do not display an increased vulnerability to infection with SARS-CoV-2. Data regarding morbidity and mortality associated with COVID-19 in cancer patients receiving ICI are less clear and often conflicting. Although mostly based on experimental data, it is possible that ICI can promote the exacerbated immune response associated with adverse outcome in COVID-19 patients. On the other hand, mounting evidence suggests that ICI might even be useful in the treatment of viral infections by preventing or ameliorating T cell exhaustion. In this context, the right timing of treatment might be essential. Nevertheless, some cancer patients treated with ICI experience autoimmune-related side effects that require the use of immunosuppressive therapies, which in turn may promote a severe course of infection with SARS-CoV-2. Although there is clear evidence that withholding ICI will have more serious consequences, further studies are urgently needed in to better evaluate the effects of ICI in patients with COVID-19 and the use of ICI during the corona pandemic in general.
Curcumin Treatment Identifies Therapeutic Targets within Biomarkers of Liver Colonization by Highly Invasive Mesothelioma Cells—Potential Links with Sarcomas
Authors: Pouliquen Daniel L. , Boissard Alice , Henry Cécile , Blandin Stéphanie , Richomme Pascal , Coqueret Olivier , Guette Catherine
Published: November 2020

Investigations of liver metastatic colonization suggest that the microenvironment is preordained to be intrinsically hospitable to the invasive cancer cells. To identify molecular determinants of that organotropism and potential therapeutic targets, we conducted proteomic analyses of the liver in an aggressive model of sarcomatoid peritoneal mesothelioma (M5-T1). The quantitative changes between SWATH-MS (sequential window acquisition of all theoretical fragmentation spectra) proteotype patterns of the liver from normal rats (G1), adjacent non-tumorous liver from untreated tumor-bearing rats (G2), and liver from curcumin-treated rats without hepatic metastases (G3) were compared. The results identified 12 biomarkers of raised immune response against M5-T1 cells in G3 and 179 liver biomarker changes in (G2 vs. G1) and (G3 vs. G2) but not in (G3 vs. G1). Cross-comparing these 179 candidates with proteins showing abundance changes related to increasing invasiveness in four different rat mesothelioma tumor models identified seven biomarkers specific to the M5-T1 tumor. Finally, analysis of correlations between these seven biomarkers, purine nucleoside phosphorylase being the main biomarker of immune response, and the 179 previously identified proteins revealed a network orchestrating liver colonization and treatment efficacy. These results highlight the links between potential targets, raising interesting prospects for optimizing therapies against highly invasive cancer cells exhibiting a sarcomatoid phenotype and sarcoma cells.
Metastatic Colonization: Escaping Immune Surveillance
Authors: Schaller Julien , Agudo Judith
Published: November 2020

Cancer immunotherapy has shifted the paradigm in cancer therapy by revitalizing immune responses against tumor cells. Specifically, in primary tumors cancer cells evolve in an immunosuppressive microenvironment, which protects them from immune attack. However, during tumor progression, some cancer cells leave the protective tumor mass, disseminating and seeding secondary organs. These initial disseminated tumor cells (DTCs) should potentially be susceptible to recognition by the immune system in the new host tissues. Although Natural Killer or T cells eliminate some of these DTCs, a fraction escape anti-tumor immunity and survive, thus giving rise to metastatic colonization. How DTCs interact with immune cells and the underpinnings that regulate imperfect immune responses during tumor dissemination remain poorly understood. Uncovering such mechanisms of immune evasion may contribute to the development of immunotherapy specifically targeting DTCs. Here we review current knowledge about systemic and site-specific immune-cancer crosstalk in the early steps of metastasis formation. Moreover, we highlight how conventional cancer therapies can shape the pre-metastatic niche enabling immune escape of newly arrived DTCs.
BNIP3 in Lung Cancer: To Kill or Rescue?
Authors: Gorbunova Anna S. , Yapryntseva Maria A. , Denisenko Tatiana V. , Zhivotovsky Boris
Published: November 2020

Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most aggressive types of cancer, which is often diagnosed at an advanced stage. Therefore, there is still urgent demand for reliable biochemical markers for lung cancer and its efficient treatment. Mitochondria functioning and mitochondrial proteins, including BNIP3, have a strong impact on lung cancer development and progression. Here, we summarized current knowledge about the BNIP3 gene and protein features and their role in cancer progression, especially in lung cancer in order to develop new therapeutic approaches associated with BNIP3.
A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue
Authors: Bellei Barbara , Migliano Emilia , Picardo Mauro
Published: November 2020

The development of a modified stromal microenvironment in response to neoplastic onset is a common feature of many tumors including cutaneous melanoma. At all stages, melanoma cells are embedded in a complex tissue composed by extracellular matrix components and several different cell populations. Thus, melanomagenesis is not only driven by malignant melanocytes, but also by the altered communication between melanocytes and non-malignant cell populations, including fibroblasts, endothelial and immune cells. In particular, cancer-associated fibroblasts (CAFs), also referred as melanoma-associated fibroblasts (MAFs) in the case of melanoma, are the most abundant stromal cells and play a significant contextual role in melanoma initiation, progression and metastasis. As a result of dynamic intercellular molecular dialogue between tumor and the stroma, non-neoplastic cells gain specific phenotypes and functions that are pro-tumorigenic. Targeting MAFs is thus considered a promising avenue to improve melanoma therapy. Growing evidence demonstrates that aberrant regulation of oncogenic signaling is not restricted to transformed cells but also occurs in MAFs. However, in some cases, signaling pathways present opposite regulation in melanoma and surrounding area, suggesting that therapeutic strategies need to carefully consider the tumor–stroma equilibrium. In this novel review, we analyze four major signaling pathways implicated in melanomagenesis, TGF-β, MAPK, Wnt/β-catenin and Hyppo signaling, from the complementary point of view of tumor cells and the microenvironment.
Oligometastatic Pancreatic Cancer to the Liver in the Era of Neoadjuvant Chemotherapy: Which Role for Conversion Surgery? A Systematic Review and Meta-Analysis
Authors: De Simoni Ottavia , Scarpa Marco , Tonello Marco , Pilati Pierluigi , Tolin Francesca , Spolverato Ylenia , Gruppo Mario
Published: November 2020

Background: the improved survival rates achieved using new polychemotherapy regimens in patients with metastatic pancreatic cancer (mPDAC) have suggested a potential role for surgery following a favorable response to initial chemotherapy (IC). The purpose of this systematic review is to summarize the available evidence on the role of surgery following IC in mPDAC, focusing on oligometastatic disease to the liver (lmPDAC). Methods: studies reporting on patients with lmPDAC undergoing surgery after IC were included. The main outcome was overall survival (OS). Results: six observational retrospective studies were included in the qualitative analysis. Data were retrieved on 2087 patients. The most common IC regimen in patients undergoing surgery was FOLFIRINOX (N 84, 73%). Only three studies reported survival comparison among patients treated with IC+surgery vs. IC alone. Median OS varied from 23 to 56 months after conversion surgery vs. 11 to 16.4 months after IC alone. Conclusions: despite wide heterogeneity of chemotherapy regimens, different downstaging criteria and potential selection biases, patients with oligometastatic lmPDAC undergoing surgery after IC have significantly higher survival rates compared to patients treated with IC alone. Future trials are needed for definition of univocal criteria of downstaging, oligometastatic definition and indications for surgery.
A Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs)
Authors: Han Shuting , Lee Suat Ying , Wang Who-Whong , Tan Yu Bin , Sim Rachel Hui Zhen , Cheong Rachael , Tan Cherlyn , Hopkins Richard , Connolly John , Shuen Wai Ho , Toh Han Chong
Published: November 2020

Biliary tract cancer (BTC) is a rare, but aggressive, disease that comprises of gallbladder carcinoma, intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with heterogeneous molecular profiles. Advanced disease has limited therapeutic options beyond first-line platinum-based chemotherapy. Immunotherapy has emerged as a viable option for many cancers with a similar unmet need. Therefore, we reviewed current understanding of the tumor immune microenvironment and recent advances in cellular immunotherapy and therapeutic cancer vaccines against BTC. We illustrated the efficacy of dendritic cell vaccination in one patient with advanced, chemorefractory, melanoma-associated antigen (MAGE)-positive gallbladder carcinoma, who was given multiple injections of an allogenic MAGE antigen-positive melanoma cell lysate (MCL)-based autologous dendritic cell vaccine combined with sequential anti-angiogenic therapy. This resulted in good radiological and tumor marker response and an overall survival of 3 years from diagnosis. We postulate the potential synergism of adding anti-angiogenic therapy, such as bevacizumab, to immunotherapy in BTC, as a rational scientific principle to positively modulate the tumor microenvironment to augment antitumor immunity.
Real Life Prospective Evaluation of New Drug-Eluting Platform for Chemoembolization of Patients with Hepatocellular Carcinoma: PARIS Registry
Authors: de Baere Thierry , Guiu Boris , Ronot Maxime , Chevallier Patrick , Sergent Géraldine , Tancredi Illario , Tselikas Lambros , Dioguardi Burgio Marco , Raynaud Lucas , Deschamps Frederic , Verset Gontran
Published: November 2020

Background and aim: Transarterial chemoembolization with drug-eluting microspheres (DEM-TACE) is recommended for patients with BCLC stage B hepatocellular carcinoma (HCC) and stage 0-A unsuitable for curative treatments. We assessed efficacy and safety along with hepatobiliary toxicities (HBT) of DEM-TACE using a novel microsphere, LifePearlTM, loaded with anthracyclines. Materials and methods: 97 patients diagnosed with HCC were prospectively enrolled and treated using LifePearlTM loaded with doxorubicin (77%) or idarubicin (23%). Safety and tolerability were assessed using CTCAE, HBT by CT/MRI scans, and tumor response by applying modified Response Evaluation Criteria in Solid Tumors (mRECIST). Follow-up was after 2 years. Results: Adverse events (AE) were reported in 73.2% of patients, majority being Grade 1–2. Grade ≥ 3 AE reported in 13.4% of patients were mainly related to postembolization syndrome. HBT were observed after 15.5% (29/187) of the DEM-TACEs. Objective response and disease control rates were 81% and 99%, respectively, as the best responses. Survival rates at one and two years were 81% and 66%, respectively, while the median overall survival (OS) was not reached. Median progression free survival was 13.7 months (95% CI: 11.3; 15.6) and median time to TACE untreatable progression was 16.7 months (95% CI: 12.7; not estimable (n.e.)). Conclusions: DEM-TACE using LifePearlTM provides a high tumor response rate in HCC patients. HBT rates within or below previously reported results for cTACE and DEM-TACE indicate a good safety profile for LifePearlTM. The trial was registered in National Library of Medicine (ID: NCT03053596).
Continuous 14 Day Infusional Ifosfamide for Management of Soft-Tissue and Bone Sarcoma: A Single Centre Retrospective Cohort Analysis
Authors: Carter Thomas J. , Milic Marina , McDerra Joanna , McTiernan Anne , Ahmed Mahbubl , Karavasilis Vasilios , Michelagnoli Maria , Windsor Rachael , Seddon Beatrice , Whelan Jeremy , Dileo Palma , Strauss Sandra J.
Published: November 2020

Ifosfamide is used to treat soft-tissue sarcoma (STS) and bone sarcoma (BS), with improved efficacy at doses above 9 g/m2/cycle. To mitigate treatment-associated toxicity with higher doses, continuous infusional ifosfamide is increasingly used. However, clinical outcome data remain limited. Single-centre retrospective analysis of patients treated with four-weekly infusional ifosfamide (14 g/m2/14d) between August 2012 and February 2019 was conducted. Radiological response, progression-free survival (PFS), overall survival (OS) and toxicity were evaluated. Eighty patients were treated—46 with STS and 34 with BS. Patients received a median of three cycles of infusional ifosfamide (1–24). Overall disease control rate (DCR) in STS was 50% (23 of 46 patients), with a median PFS of 3.8 months, and median OS of 13.0 months. In synovial sarcoma (SS), DCR was 80% (12/15), median PFS 8.1 months and median OS 20.9 months. Overall DCR in BS (34 patients) was 30%, with a median PFS of 2.5 months and median OS of 6.2 months. Five patients (6%) stopped treatment due to toxicity alone within the first two cycles. A further 10 patients stopped treatment due to toxicity during later treatment cycles (12%) and 18 patients (23%) required dose modification. Forty-five patients (56%) experienced grade (G) 3/4 haematological toxicity, with 12 episodes of febrile neutropenia and one treatment-related death. Twenty-seven patients (34%) experienced G3/4 non-haematological toxicity, most commonly nausea and vomiting (10, 13%). In summary, infusional ifosfamide has efficacy in STS, most notable in SS. Benefit appears limited in BS. Treatment is associated with toxicity that requires specialist supportive care.
The Influence of Pretherapeutic and Preoperative Sarcopenia on Short-Term Outcome after Esophagectomy
Authors: Grün Johanna , Elfinger Lea , Le Han , Weiß Christel , Otto Mirko , Reißfelder Christoph , Blank Susanne
Published: November 2020

By introducing minimally invasive surgery the rate of postoperative morbidity in esophageal cancer patients could be reduced. But esophagectomy is still associated with a relevant risk of postoperative morbidity and mortality. Patients often present with nutritional deficiency and sarcopenia even at time of diagnosis. This study focuses on the influence of skeletal muscle index (SMI) on postoperative morbidity and mortality. Fifty-two patients were included in this study. SMI was measured using computer tomographic images at the time of diagnosis and before surgery. Then, SMI and different clinicopathological and demographic features were correlated with postoperative morbidity. There was no correlation between SMI before neoadjuvant therapy (p = 0.5365) nor before surgery (p = 0.3530) with the short-term postoperative outcome. Regarding cholesterol level before surgery there was a trend for a higher risk of complications with lower cholesterol levels (p = 0.0846). Our findings suggest that a low preoperative SMI does not necessarily predict a poor postoperative outcome in esophageal cancer patients after esophagectomy but that there are many factors that influence the nutritional status of cancer patients. To improve nutritional status, cancer patients at our clinic receive specialized nutritional counselling during neoadjuvant treatment as well as after surgery.
SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion
Authors: Conn Vanessa M. , Gabryelska Marta , Marri Shashikanth , Stringer Brett W. , Ormsby Rebecca J. , Penn Timothy , Poonnoose Santosh , Kichenadasse Ganessan , Conn Simon J.
Published: November 2020

High-throughput RNA sequencing (RNA-seq) and dedicated bioinformatics pipelines have synergized to identify an expansive repertoire of unique circular RNAs (circRNAs), exceeding 100,000 variants. While the vast majority of these circRNAs comprise canonical exonic and intronic sequences, microexons (MEs)—which occur in 30% of functional mRNA transcripts—have been entirely overlooked. CircRNAs which contain these known MEs (ME-circRNAs) could be identified with commonly utilized circRNA prediction pipelines, CIRCexplorer2 and CIRI2, but were not previously recognized as ME-circRNAs. In addition, when employing a bespoke bioinformatics pipeline for identifying RNA chimeras, called Hyb, we could also identify over 2000 ME-circRNAs which contain novel MEs at their backsplice junctions, that are uncalled by either CIRCexplorer2 or CIRI2. Analysis of circRNA-seq datasets from gliomas of varying clinical grades compared with matched control tissue has shown circRNAs have potential as prognostic markers for stratifying tumor from healthy tissue. Furthermore, the abundance of microexon-containing circRNAs (ME-circRNAs) between tumor and normal tissues is correlated with the expression of a splicing associated factor, Serine/arginine repetitive matrix 4 (SRRM4). Overexpressing SRRM4, known for regulating ME inclusion in mRNAs critical for neural differentiation, in human HEK293 cells resulted in the biogenesis of over 2000 novel ME-circRNAs, including ME-circEIF4G3, and changes in the abundance of many canonical circRNAs, including circSETDB2 and circLRBA. This shows SRRM4, in which its expression is correlated with poor prognosis in gliomas, acts as a bona fide circRNA biogenesis factor. Given the known roles of MEs and circRNAs in oncogenesis, the identification of these previously unrecognized ME-circRNAs further increases the complexity and functional purview of this non-coding RNA family.
Enhancing Salt Tolerance of Plants: From Metabolic Reprogramming to Exogenous Chemical Treatments and Molecular Approaches
Authors: Patel Manish Kumar , Kumar Manoj , Li Weiqiang , Luo Yin , Burritt David J. , Alkan Noam , Tran Lam-Son Phan
Published: November 2020

Plants grow on soils that not only provide support for root anchorage but also act as a reservoir of water and nutrients important for plant growth and development. However, environmental factors, such as high salinity, hinder the uptake of nutrients and water from the soil and reduce the quality and productivity of plants. Under high salinity, plants attempt to maintain cellular homeostasis through the production of numerous stress-associated endogenous metabolites that can help mitigate the stress. Both primary and secondary metabolites can significantly contribute to survival and the maintenance of growth and development of plants on saline soils. Existing studies have suggested that seed/plant-priming with exogenous metabolites is a promising approach to increase crop tolerance to salt stress without manipulation of the genome. Recent advancements have also been made in genetic engineering of various metabolic genes involved in regulation of plant responses and protection of the cells during salinity, which have therefore resulted in many more basic and applied studies in both model and crop plants. In this review, we discuss the recent findings of metabolic reprogramming, exogenous treatments with metabolites and genetic engineering of metabolic genes for the improvement of plant salt tolerance.
Reach, Recruitment, Dose, and Intervention Fidelity of the GoActive School-Based Physical Activity Intervention in the UK: A Mixed-Methods Process Evaluation
Authors: Jong Stephanie T. , Croxson Caroline H. D. , Foubister Campbell , Brown Helen Elizabeth , Guell Cornelia , Lawlor Emma R. , Wells Emma K. , Wilkinson Paul O. , Wilson Edward C. F. , van Sluijs Esther M. F. , Corder Kirsten
Published: November 2020

School-based multi-component physical activity (PA) promotion is advocated; however, research has indicated that a multi-component approach may not always be effective at increasing adolescent PA. Evaluation of the GoActive 12-week multi-component school-based intervention showed no effect on adolescent PA. A mixed-methods process evaluation was embedded to facilitate greater understanding of the results, to elicit subgroup perceptions, and to provide insight into contextual factors influencing intervention implementation. This paper presents the reach, recruitment, dose, and fidelity of GoActive, and identifies challenges to implementation. The process evaluation employed questionnaires (1543 Year 9s), individual interviews (16 Year 9s; 7 facilitators; 9 contact teachers), focus groups (48 Year 9s; 58 mentors), alongside GoActive website analytics and researcher observations. GoActive sessions reached 39.4% of Year 9s. Intervention satisfaction was relatively high for mentors (87.3%) and facilitators (85.7%), but lower for Year 9s (59.5%) and teachers (50%). Intervention fidelity was mixed within and between schools. Mentorship was the most implemented component. Factors potentially contributing to low implementation included ambiguity of the roles subgroups played within intervention delivery, Year 9 engagement, institutional support, and further school-level constraints. Multiple challenges and varying contextual considerations hindered the implementation of GoActive in multiple school sites. Methods to overcome contextual challenges to implementation warrant in-depth consideration and innovative approaches.
Pediatric Anesthesia Specialty Societies and Multi-Institutional Collaborations
Authors: Walters Camila , Kynes James , Reddy Srijaya , Crockett Christy , Lovejoy Hannah , Lorinc Amanda
Published: November 2020

Pediatric anesthesiology is a subspecialty of anesthesiology that deals with the high-risk pediatric population. The specialty has made significant advancement in large collaborative efforts to study and increase patient safety, including the creation of international societies, a dedicated journal, special committees and interest groups, and multi-institution databases for research and quality improvement. Readily available resources were created to help with the education of future pediatric anesthesiologists as well as continuing medical education. Conclusions: Specialty societies and collaborations in pediatric anesthesia are crucial for continuous improvement in the care of children. They promote research, education, quality improvement, and advocacy at the local, national, and international level.
Estimation of the Reliability of a Stress–Strength System from Poisson Half Logistic Distribution
Authors: Muhammad Isyaku , Wang Xingang , Li Changyou , Yan Mingming , Chang Miaoxin
Published: November 2020

This paper discussed the estimation of stress-strength reliability parameter R=P(Y<X) based on complete samples when the stress-strength are two independent Poisson half logistic random variables (PHLD). We have addressed the estimation of R in the general case and when the scale parameter is common. The classical and Bayesian estimation (BE) techniques of R are studied. The maximum likelihood estimator (MLE) and its asymptotic distributions are obtained; an approximate asymptotic confidence interval of R is computed using the asymptotic distribution. The non-parametric percentile bootstrap and student’s bootstrap confidence interval of R are discussed. The Bayes estimators of R are computed using a gamma prior and discussed under various loss functions such as the square error loss function (SEL), absolute error loss function (AEL), linear exponential error loss function (LINEX), generalized entropy error loss function (GEL) and maximum a posteriori (MAP). The Metropolis–Hastings algorithm is used to estimate the posterior distributions of the estimators of R. The highest posterior density (HPD) credible interval is constructed based on the SEL. Monte Carlo simulations are used to numerically analyze the performance of the MLE and Bayes estimators, the results were quite satisfactory based on their mean square error (MSE) and confidence interval. Finally, we used two real data studies to demonstrate the performance of the proposed estimation techniques in practice and to illustrate how PHLD is a good candidate in reliability studies.
Assessment of Climate Change Sentiment, Engagement and Adaptation through a Community-Based Outreach Campaign and Questionnaire across the United States
Authors: Masri Shahir , Simolaris Athina , Hopfer Suellen , Wu Jun
Published: November 2020

(1) Background: Human activity is warming the planet and destabilizing the climate through greenhouse gas emissions, which underscores the need for climate communication to overcome barriers to action. (2) Methods: We launched a five-month campaign that included questionnaires (n = 500) and one-on-one interviews (n = 24) to assess climate change sentiment, engagement, adaptation, as well as understand who climate outreach reaches and the observations and concerns such groups report across the U.S. so as to better understand the local context of climate change and enable more effective climate communication and outreach in the future. (3) Results: Results showed outreach efforts to mostly reach college educated Caucasians who identified as Democrats. “Future generations” was the most frequently ranked climate concern, with the economy, property value, and national security ranked last. Communities frequently observed hotter temperatures, increased flooding, and species impacts. Among “climate-concerned” individuals, the majority reported never contacting a local politician about climate change. College students least frequently reported climate change as a top priority and reported a low frequency of civic engagement on the issue. In-person interviews highlighted climate impacts disproportionately affecting low-income communities and communities of color, such as heat-related mortality and gentrification. Climate adaptation strategies were underway, but mostly among farmers, ecologists, and non-governmental organizations (NGO) workers. (4) Discussion: This study helps inform elected officials, urban planners, and climate communicators as it relates to the allocation of resources for climate adaptation and education, and highlights key knowledge gaps that deserve focus by future outreach efforts.
Analysis of Area-Efficiency vs. Unrolling for eSTREAM Hardware Portfolio Stream Ciphers
Authors: Alharbi Fares , Hameed Muhammad Khurram , Chowdhury Anusha , Khalid Ayesha , Chattopadhyay Anupam , Javed Ibrahim Tariq
Published: November 2020

The demand for low resource devices has increased rapidly due to the advancements in Internet-of-things applications. These devices operate in environments that have limited resources. To ensure security, stream ciphers are implemented on hardware due to their speed and simplicity. Amongst different stream ciphers, the eSTREAM ciphers stand due to their frugal implementations. This work probes the effect of unrolling on the efficiency of eSTREAM ciphers, including Trivium, Grain (Grain 80 and Grain 128) and MICKEY (MICKEY 2.0 and MICKEY-128 2.0). It addresses the question of optimal unrolling for designing high-performance stream ciphers. The increase in the area consumption is also bench-marked. The analysis is conducted to identify efficient design principles for ciphers. We experimentally show that the resulting performance after unrolling may disagree with the theoretical prediction when the effects of technology library are considered. We report pre-layout synthesis results on 65 and 130 nm ASIC technology as well as synthesis results for Xilinx FPGA platform in support of our claim. Based on our findings, cipher design and implementation suggestions are proposed to aid hardware designers. Furthermore, we explore why and where area-efficiency for these ciphers saturate.
Stannite Quaternary Cu2M(M = Ni, Co)SnS4 as Low Cost Inorganic Hole Transport Materials in Perovskite Solar Cells
Authors: Shadrokh Zohreh , Sousani Shima , Gholipour Somayeh , Dehghani Zahra , Abdi Yaser , Roose Bart
Published: November 2020

In this study, inorganic stannite quaternary Cu2M(M = Ni, Co)SnS4 (CMTS) is explored as a low-cost, earth abundant, environmentally friendly and chemically stable hole transport material (HTM). CMTS nanoparticles were synthesized via a facile and mild solvothermal method and processed into aggregated nanoparticle inks, which were applied in n-i-p perovskite solar cells (PSCs). The results show that Cu2NiSnS4 (CNiTS) is more promising as an HTM than Cu2CoSnS4 (CCoTS), showing efficient charge injection as evidenced by considerable photoluminescence quenching and lower series resistance from Nyquist plots, as well as higher power conversion efficiency (PCE). Moreover, the perovskite layer coated by the CMTS HTM showed superior environmental stability after 200 h light soaking in 50% relative humidity, while organic HTMs suffer from a severe drop in perovskite absorption. Although the obtained PCEs are modest, this study shows that the cost effective and stable inorganic CMTSs are promising HTMs, which can contribute towards PSC commercialization, if the field can further optimize CMTS energy levels through compositional engineering.
Key Operational Issues on the Integration of Large-Scale Solar Power Generation—A Literature Review
Authors: Li Wei , Ren Hui , Chen Ping , Wang Yanyang , Qi Hailong
Published: November 2020

Solar photovoltaic (PV) power generation has strong intermittency and volatility due to its high dependence on solar radiation and other meteorological factors. Therefore, the negative impact of grid-connected PV on power systems has become one of the constraints in the development of large scale PV systems. Accurate forecasting of solar power generation and flexible planning and operational measures are of great significance to ensure safe, stable, and economical operation of a system with high penetration of solar generation at transmission and distribution levels. In this paper, studies on the following aspects are reviewed: (1) this paper comprehensively expounds the research on forecasting techniques of PV power generation output. (2) In view of the new challenge brought by the integration of high proportion solar generation to the frequency stability of power grid, this paper analyzes the mechanisms of influence between them and introduces the current technical route of PV power generation participating in system frequency regulation. (3) This section reviews the feasible measures that facilitate the inter-regional and wide-area consumption of intermittent solar power generation. At the end of this paper, combined with the actual demand of the development of power grid and PV power generation, the problems that need further attention in the future are prospected.
Fast Power Emulation Approach to the Operation of Photovoltaic Power Plants Made of Different Module Technologies
Authors: Pelin Denis , Žnidarec Matej , Šljivac Damir , Brandis Andrej
Published: November 2020

This paper gives a comprehensive approach to the emulation of photovoltaic (PV) plants made of different module technologies as well as varying peak power through the advanced fast PV power emulation technique. Even though PVs are recognized as a technology for CO2 emissions mitigation, the proposed emulation technique provides the opportunity to replicate PV plant operation without a carbon footprint because of its working principle. The process of PV power plant emulation consists of several stages which are described in detail. An algorithm for determining PV power plant configuration based on the technical characteristics of the PV emulation system equipment is developed and presented, as well as an algorithm for preparing data on the current–voltage (i–v) characteristics used as input data into programmable sources that mimic the power plant PV array. A case study of a single day operation of PV power plants made of two different topologies and technologies was carried out with the fast PV power emulation approach and the results are evaluated and presented.
Design and Analysis of Second-Order Sliding Mode Controller for Active Magnetic Bearing
Authors: Wang Xiaoyuan , Zhang Yaopeng , Gao Peng
Published: November 2020

An active magnetic bearing (AMB) is a kind of high-performance bearing that uses controllable electromagnetic force to levitate the rotor. Its control performance directly affects the operation characteristics of high-speed motors and other electromechanical products. The magnetic bearing control model is nonlinear and difficult to control. Sliding mode control algorithm can be used in the magnetic bearing control system, but the traditional sliding mode control has the problem of high-frequency chattering, which affects the operation stability of magnetic bearings. Based on the second-order sliding mode control algorithm, a new second-order sliding mode controller for active magnetic bearing control was designed, and the stability of the designed sliding mode control law was proven by Lyapunov criterion. On the basis of the established active magnetic bearing control model, the numerical analysis of the designed controller was carried out, and the control effect was compared with that obtained by the exponential reaching law for the sliding mode control algorithm. The experimental results show that the designed sliding mode controller has better dynamic performance and stability than the exponential reaching law for the sliding mode controller.