bluuebunny/crossref_metadata_2025 huggingface dataset:
La période oratoire dans les remontrances parlementaires (entre la fin du xvie et le début du xviiie siècle)
Authors: Hache Sophie
Published: November 2024

Quelles formes les périodes empruntent-elles dans les discours français, avec quels usages et quels effets ? L’étude d’une catégorie particulière de discours permet de nourrir cette réflexion : les remontrances parlementaires, qui constituent un genre oratoire institutionnel dont la forme est codifiée de la Renaissance à la Révolution, et qui relèvent du style élevé traditionnellement associé aux périodes. En s’appuyant sur deux recueils publiés à un siècle d’intervalle, le Recueil des remonstrances et actions publiques, faictes en la cour de Parlement et les Remontrances faites aux ouvertures de la Saint Martin de la Cour Souveraine de Lorraine et Barrois, l’article s’intéresse aux caractères qui font de la période un modèle : sa fréquence d’emploi reste stable, tandis que ses formes deviennent plus régulières et repérables, sur le plan syntaxique, mais aussi rythmique – conformément aux prescriptions des traités d’éloquence.
Interrelationships Between Non-Financial Perspectives of Balanced Scorecard: Evidence from Sri Lankan Public Listed Companies
Authors: Perera P. R. M. R. , Kariyawasam A. H. N.
Published: November 2024

The objective of this study is to examine the interrelationship among the non-financial perspectives of the Balanced Scorecard. Out of 285 PLCs listed, 102 PLCs in the Colombo Stock Exchange; Sri Lanka have responded in this study and data collected with a standard questionnaire. Respondents were from the managerial capacity of the companies. The questionnaire captures all aspects that construct each non-financial perspective of the Balanced Scorecard using 5-point Likert scale. Two factors under each non-financial perspective, totaling to six factors were found through a factor analysis and the factors were used in finding the interrelationship between non-financial perspectives. Results reveal that the learning and growth perspective has a relationship with the internal business process perspective where both internal oriented learning and external oriented learning are highly correlated with collaborative process efficiency. The relationship between internal business process perspective and customer perspective is evidenced by the strong correlation that customer satisfaction has with both product delivery process efficiency and collaborative process efficiency. Learning and growth perspective reveals a relationship with the customer perspective having internal oriented learning strongly correlated with customer satisfaction. This study contributes to the body of knowledge by confirming the underlying assumption in the Balanced Scorecard and notifying firms that have or haven’t adopted the Balanced Scorecard approach with a general conclusion to focus on the non-financial perspectives by understanding the interrelationship between them.
An Examination of Performance Audit Principles in Public Sector Audit: An Interpretive Study in Bangladesh
Authors: Rajib Salah Uddin , Hoque Mahfuzul
Published: November 2024

This paper aims to assess the principles of performance auditing (PA) in the public sector of Bangladesh. The PA is conducted by the supreme audit institution of the country, the Comptroller and Auditor General (OCAG). To attain the objective this study analyses all the performance auditing (PA) reports published by the OCAG. There are 19 published PA reports. The PA report has been classified into several principles, including the 3Es as suggested by the International Organization of Supreme Audit Institutions (INTOSAI). The level of compliance has been integrated into the classification scheme of the PA reports. The contents analysis demonstrates that Effectiveness has been addressed in the highest number of reports whereas Efficiency has not been addressed in any reports. The extended classifications (beyond 3Es) have been reflected in the PA reports rarely. In addition, compliance issues have been presented weakly in the reports. The findings have been analyzed in line with the contemporary studies in public sector auditing. Public sector auditing has been studied merely in developing countries. This study will contribute to this aspect. Moreover, the future potential research avenue has been explored in this study. The limitation of this study is confined in the number of reports which is 19. Therefore, these limited available data and the uniqueness of the developing country defy the generalization of the findings but can contribute to the PA research in developing countries.
Contribution of Dried Fish to Food and Nutrition Security in Sri Lanka: A review
Authors: Jayasekara I.G.R.I. , Wijekoon A.P. , Somaratne G.M.
Published: November 2024

Dried fish is a widely consumed dietary source of macro and micronutrients, especially in low- and middle-income households. It is a pool of bioavailable high-quality animal protein with essential amino acids, essential minerals, vitamins, omega 3 and 6 fatty acids. Dried fish is generally acceptable to all regardless of region, religion, race, gender, and age across Sri Lanka. However, the role of dried fish production had been rarely elaborated on food and nutrition security in Sri Lanka. Therefore, this review aimed at delivering an overview of the contribution of dried fish towards food and nutrition security in Sri Lanka together with nutritional value of fish and dried fish products. The aim of dried fish production is to deliver a safe and wholesome final product to the consumer by preserving fish facilitating long shelf life. Sun drying, salting and drying, and smoked drying are the main dried fish processing methods. The contribution of dried fish is high in poor and marginalized communities in Sri Lanka. Dried fish provides a significant proportion of affordable and readily available animal protein to a large segment of the people in the country. Adequate emphasis should be given to enhance the dried fish production to meet the requirements. More investments are necessary to enhance the production of safe and quality dried fish.
Contribution of Coconut Fat to the Daily Calorie and Fat Intake of Adult Women from Rural Settings in Sri Lanka
Authors: Fernando M.G. , Josephkumar T. , Jayasinghe-Mudalige U.K. , Silva K.D.R.R.
Published: November 2024

Background: Coconut is a major ingredient in habitual South-Asian diets including Sri Lanka and is a major source of fat. Reliable and recent information on dietary energy and macronutrient intakes and coconut consumption levels are lacking.
Aim: This study aimed to assess the dietary energy and macronutrient intake and the contribution of coconut to the energy and fat intake of women in rural settings in Sri Lanka.
Methods: A cross-sectional survey was conducted with 408 women (age: 33 ± 6 years) living in rural settings. Nutrient intakes were determined using 24-hour recalls. Socio-demographic and lifestyle characteristics, perceptions, and practices of coconut consumption were collected by an interviewer-administered questionnaire. Habits of coconut consumption were assessed by a food frequency questionnaire.
Results: The daily energy intake of women was 1765 ± 390 kcal/d and the fat intake was 46 ± 18 g/d, which accounted for 23 ± 7% of the total energy intake. The polyunsaturated: saturated fat (P:S) ratio was 0.08. Coconuts contributed to 14 ± 6% of the total energy, 54 ± 21% of the total fat, and 68 ± 26% of the total saturated fat intake. Coconut milk was the major source of coconut fat (33 ± 20%) in their habitual diet followed by coconut scrapes (15 ± 14%) and coconut oil (6 ± 8%).
Conclusions: Coconut contributes to more than half of the total fat and two-thirds of the saturated fat in the high saturated-low polyunsaturated fat diet of women in the rural setting in Sri Lanka. Coconut milk is the major individual contributor of fats.
Fasting Plasma Glucose Levels in Relation to the Nutritional Status, Dietary Intake, and Lifestyle Factors among a Group of Sri Lankan Undergraduates: A Cross-Sectional Study
Authors: Kaldera P.H. , Wickramatilake C.M.
Published: November 2024

Introduction: Diabetes mellitus (DM) is a global public health concern intricately linked to dietary habits, physical inactivity, and other lifestyle factors.
Objectives: This cross-sectional study aimed to elucidate the associations between fasting plasma glucose (FPG) levels, nutritional status, dietary patterns, and lifestyle factors among undergraduates at the Faculty of Allied Health Sciences, University of Ruhuna, Sri Lanka.
Materials & Methods: It was a descriptive cross-sectional study. Data were collected via a self-administered questionnaire. Anthropometric measurements were obtained following standard protocols. Fasting plasma glucose was quantified using the GOD- PAP method. Statistical analysis was performed using appropriate statistical tools.
Results: Participants (n = 100) were in the age range of 20 - 28 years and 58% were females. Their FPG levels ranged from 70 to 108 mg/dL with 3% of impaired fasting glycaemia (IFG) and no instances  of DM. Mean (SD) BMI was 20.9 (3.4) kg/m2. Among them, 29% were overweight or obese. A statistically significant positive correlation was observed between FPG and both waist circumference (p=0.004) and BMI (p=0.019). Dietary assessment revealed suboptimal adherence to recommended portion sizes across all six food categories. Despite 82% consuming three main meals per day, meal-skipping was reported by 36% of the participants. Adequate water intake was reported among 60%, the majority abstained from alcohol and smoking. However, a considerable percentage reported consumption of junk foods. Physical inactivity and inadequate sleep were reported by 73% and 72% of the participants respectively.
Conclusions: The prevalence of IFG among the studied undergraduate population is low. However, the majority exhibited suboptimal dietary practices and insufficient engagement in physical activities, which warrant further attention for preventive health strategies.
Health, nutrition and age-associated illnesses: The way forward
Authors: Madhujith Terrence , Wickramatilake Chandima
Published: November 2024

No abstract available.
Pulmonary infection with an unusual microorganism
Authors: Samet Mohammad , Soleimani Salehabadi Hossein
Published: November 2024

Pulmonary trichomoniasis is an underdiagnosed disease. In most cases, there is an underlying clinical condition related to immunosuppression. The results of molecular biology techniques indicate that trichomonad infections have been significantly underestimated. A 7-year-old girl with a medical history of suspected juvenile rheumatoid arthritis presented with a fever, chills, and a productive cough. Her chest computed tomography scan indicated a pericardial effusion and consolidation in the left lower lobe. In direct microscopy of the bronchoalveolar lavage fluid, we identified a motile and flagellated organism. Based on the morphology, size, and rolling motility, we identified this organism as Trichomonas hominis. The patient's fever stopped after 3 days of intravenous metronidazole administration. In immunocompromised patients with evidence of pneumonia, sputum or bronchial samples should be examined more carefully. The possibility of unusual pathogens should be considered if they do not respond to antibacterial treatments.
Game-theoretic Statistical Inference: Optional Sampling, Universal Inference, and Multiple Testing Based on E-values
Authors: Grünwald Peter , Ramdas Aaditya , Wang Ruodu , Ziegel Johanna
Published: November 2024

This half-size MFO workshop brings together researchers in mathematical statistics, probability theory, machine learning, medical sciences, and economics to discuss recent developments in sequential inference. New sequential inference methods that build on nonnegative martingale techniques allow us to elegantly solve prominent shortcomings of traditional statistical hypothesis tests. Instead of p-values, they are based on e-values which have the added benefit that their meaning is much easier to communicate to applied researchers, due to their intuitive interpretation in terms of the wealth of a gambler playing a hypothetically fair game. Significant new contributions to this fast growing research area will be presented in order to stimulate collaborations, discuss and unify notation and concepts in the fields, and tackle a variety of open problems and address current major challenges.
Statistical Physics and Random Surfaces
Authors: Garban Christophe , Miller Jason , Sheffield Scott
Published: November 2024

This conference featured a diverse group of participants, from various career stages, to study problems in several hot topics that have grown increasingly prominent and interrelated in recent years. These included the following: (1) random surface models (Liouville quantum gravity, random planar maps, etc.) (2) random curve models (Schramm–Loewner evolution, conformal loop ensembles, etc.) (3) gauge theory models (various forms of lattice Yang–Mills, other approximations) (4) spin models and height functions (including delocalization problems) (5) dimer models (two and higher dimensions versions) (6) conformal field theory (Liouville theory, other theories related to SLE) The conference enabled participants to communicate about the most recent break-throughs and lay the groundwork for further collaborative progress.
Complexity Theory
Authors: Bürgisser Peter , Dinur Irit , Vadhan Salil
Published: November 2024

Computational Complexity Theory is the mathematical study of the intrinsic power and limitations of computational resources like time, space, or randomness.The current workshop focused on recent developments in various sub-areas including fine-grained complexity, algorithmic fairness, pseudorandomness, cryptography, arithmetic complexity, Markov Chain Monte Carlo, structure vs. randomness in combinatorics and complexity, meta-complexity, and the complexity of approximation problems. Many of the developments are related to diverse mathematical fields such as algebra, geometry, combinatorics, analysis, and coding theory.
Statistics and Learning Theory in the Era of Artificial Intelligence
Authors: Bunea Florentina , Dalalyan Arnak , Nowak Robert , van de Geer Sara
Published: November 2024

The workshop highlighted recent theoretical advances on inference in high-dimensional statistical models based on the interplay of techniques from mathematical statistics, machine learning, theoretical computer science and related areas. The workshop brought together about 50 researchers in order to present new results, exchange ideas and explore open problems.
Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions
Authors: Gu Ke , Feng Xiao-Mei , Sun Shao-Qing , Hao Xing-Yao , Wen Yong
Published: November 2024

BACKGROUND

Human periodontal ligament stem cells (PDLSCs) regenerate oral tissue. In vitro expansion causes replicative senescence in stem cells. This causes intracellular reactive oxygen species (ROS) accumulation, which can impair stem cell function. Tissue engineering efficiency is reduced by exogenous ROS stimulation, which causes premature senescence under oxidative stress. Melatonin (MT), a powerful free radical scavenger, can delay PDLSCs senescence but may not maintain stemness under oxidative stress. This experiment examined the effects of hydrogen peroxide-induced oxidative stress on PDLSCs’ apoptosis, senescence, and stemness.

AIM

To determine if MT can reverse the above effects along with the underlying molecular mechanisms involved.

METHODS

PDLSCs were isolated from human premolars and cultured in different conditions. Flow cytometry was used to characterize the cell surface markers of PDLSCs. Hydrogen peroxide was used to induce oxidative stress in PDLSCs. Cell cycle, proliferation, apoptosis, differentiation, ROS, and senescence-associated β-galactosidase activity were assessed by various assays. Reverse transcription-polymerase chain reaction and western blot were used to measure the expression of genes and proteins related to stemness and senescence.

RESULTS

MT increases Yes-associated protein expression and maintains cell stemness in an induced inflammatory microenvironment, which may explain its therapeutic effects. We examined how MT affects PDLSCs aging and stemness and its biological mechanisms.

CONCLUSION

Our study reveals MT’s role in regulating oxidative stress in PDLSCs and Yes-associated protein-mediated activity, providing insights into cellular functions and new therapeutic targets for tissue regeneration.
Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice
Authors: Xiao Kai-Zhen , Liao Gui , Huang Guang-Yu , Huang Yun-Long , Gu Rong-He
Published: November 2024

BACKGROUND

We investigated the efficacy of intra-articular injection of human umbilical cord mesenchymal stem cells (hUC-MSCs) for the treatment of osteoarthritis (OA) progression in the knee joint. Although many experimental studies of hUC-MSCs have been published, these studies have mainly used fetal bovine serum-containing cultures of hUC-MSCs; serum-free cultures generally avoid the shortcomings of serum-containing cultures and are not subject to ethical limitations, have a wide range of prospects for clinical application, and provide a basis or animal experimentation for clinical experiments.

AIM

To study the therapeutic effects of serum-free hUC-MSCs (N-hUCMSCs) in a mouse model of knee OA.

METHODS

Fifty-five male C57BL/6 mice were randomly divided into six groups: The blank control group, model control group, serum-containing hUC-MSCs (S-hUCMSC) group, N-hUCMSC group and hyaluronic acid (HA) group. After 9 weeks of modeling, the serum levels of interleukin (IL)-1β and IL-1 were determined. Hematoxylin-eosin staining was used to observe the cartilage tissue, and the Mankin score was determined. Immunohistochemistry and western blotting were used to determine the expression of collagen type II, matrix metalloproteinase (MMP)-1 and MMP-13.

RESULTS

The Mankin score and serum IL-1 and IL-1β and cartilage tissue MMP-1 and MMP-13 expression were significantly greater in the experimental group than in the blank control group (P < 0.05). Collagen II expression in the experimental group was significantly lower than that in the blank control group (P < 0.05). The Mankin score and serum IL-1 and IL-1β and cartilage tissue MMP-1 and MMP-13 levels the experimental group were lower than those in the model control group (P < 0.05). Collagen II expression in the experimental group was significantly greater than that in the model control group (P < 0.05).

CONCLUSION

N-hUCMSC treatment significantly alleviate the pathological damage caused by OA. The treatment effects of the S- hUCMSC group and HA group were similar.
Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferation-inducing ligand
Authors: Kim Hyung-Jin , Lee Do Sang , Park Jung Hyun , Hong Ha-Eun , Choi Ho Joong , Kim Ok-Hee , Kim Say-June
Published: November 2024

BACKGROUND

Recent advancements in nanomedicine have highlighted the potential of exosome (Ex)-based therapies, utilizing naturally derived nanoparticles, as a novel approach to targeted cancer treatment.

AIM

To explore the targetability and anticancer effectiveness of small interfering peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 RNA (siPIN1)-loaded soluble a proliferation-inducing ligand (sAPRIL)-targeted Exs (designated as tEx[p]) in the treatment of colon cancer models.

METHODS

tEx was generated by harvesting conditioned media from adipose-derived stem cells that had undergone transformation using pDisplay vectors encoding sAPRIL-binding peptide sequences. Subsequently, tEx[p] were created by incorporating PIN1 siRNA into the tEx using the Exofect kit. The therapeutic efficacy of these Exs was evaluated using both in vitro and in vivo models of colon cancer.

RESULTS

The tEx[p] group exhibited superior anticancer effects in comparison to other groups, including tEx, Ex[p], and Ex, demonstrated by the smallest tumor size, the slowest tumor growth rate, and the lightest weight of the excised tumors observed in the tEx[p] group (P < 0.05). Moreover, analyses of the excised tumor tissues, using western blot analysis and immunohistochemical staining, revealed that tEx[p] treatment resulted in the highest increase in E-cadherin expression and the most significant reduction in the mesenchymal markers Vimentin and Snail (P < 0.05), suggesting a more effective inhibition of epithelial-mesenchymal transition tEx[p], likely due to the enhanced delivery of siPIN1.

CONCLUSION

The use of bioengineered Exs targeting sAPRIL and containing siPIN1 demonstrated superior efficacy in inhibiting tumor growth and epithelial-mesenchymal transition, highlighting their potential as a therapeutic strategy for colon cancer.
Resilience and challenges: Evaluating the impact of stress conditions on mesenchymal stem cells across different passages
Authors: Ding Yue , Lin Fang , Liang Xiao-Ting
Published: November 2024

This article discussed a study by Almahasneh et al , which investigated how high glucose and severe hypoxia affected mesenchymal stem cells (MSCs) at different passages. This research provides insights into the resilience of higher-passage MSCs under stress conditions, challenging the common use of lower passage MSCs in clinical settings. While this study offers valuable perspectives on the adaptability of MSCs, it relies mainly on in vitro results from a single cell line, limiting broader applicability. It highlights the need for more comprehensive in vivo studies to validate these findings and better understand MSC behavior in clinical scenarios.
The Effect of Matriconditioning Enriched Biofertilizer and Washed Rice Water to Enhance Seed Germination, IAA Content and Seeding Growth on Shallot (Allium cepa L.)
Authors: Sundahri  , Saputra Muhamad Wahyu
Published: November 2024

Shallot seeds are a healthier option for cultivating shallots, as they reduce seed-borne disease infections, but they have a low germination rate. This study examined the impact of matriconditioning enriched with plant growth-promoting rhizobacteria (PGPRs) and rice washing water (WRW) on increasing germination, IAA content and growth of shallot seeds. The matriconditioning treatments included P0 (control), P1 (PGPR-absent), and PGPR presence in P2 (PGPR-Rhizomax), P3 (PGPR-BenprimA), and P4 (PGPR-FloraOne). The WRW treatments included L0 (0%), L1 (50%), and L2 (100%). The shallot seeds used are deteriorated, with moisture content and germination rates below the quality standards set by the Ministry of Agriculture of the Republic of Indonesia. The research revealed that treatment with P2 was the best result on seed germination and seedling root length. The treatment with P4 was the best result on seedling dry weight. The WRW treatment with L2 exhibited the best result in seed germination, seedling root length, and seedling dry weight. The combination of P2L2 demonstrated the best result on seed germination. The treatment with matricondiitoning increased shallot sprouts IAA content in 13-day-olds compared to controls. Also, the treatment with WRW linearly increased the IAA content in 13-day-old shallot sprouts.
Evaluation of Antibacterial and Antibiofilm Effects from Soil Streptomyces spp. against Multidrug-Resistant Bacteria
Authors: Prastya Muhammad Eka , Simbolon Sumihartati , Priyanto Jepri  Agung , Hasidu La Ode Abdul Fajar , Permatasari Vera , Primahana Gian , Dewi Rizna Triana , Kristiana Rhesi , Suryanti Erma
Published: November 2024

The global increase in multidrug-resistant (MDR) bacterial infection has rapidly gained concern globally. This study aimed to investigate antibacterial and antibiofilm potential of 25 soil actinomycete strains against MDR strains including Escherichia coli strain M4, Pseudomonas aeruginosa strain M19, Klebsiella pneumoniae strain M19, Bacillus subtilis strain M18, and Methicillin Resistant Staphylococcus aureus (MRSA). In this study, three actinomycete isolates encoded APM-7, APM-11, and APM-21 showed a strong and broad antibacterial spectrum. The minimum inhibitory concentration (MIC) of extracts derived from these isolates was ranged from 78 μg/ml to 10,000 μg/ml. In addition, The extracts also displayed significant biofilm inhibition values ranging from 6.06 to 72.4%. Based on the results,  APM-21 extract had the best antibacterial and antibiofilm activities with the strongest values against MRSA. According to the nucleotide sequencing of the 16S rRNA gene, APM-7, APM-11, and APM-21 strains possessed similar identities with Streptomyces cyaneus, Streptomyces coerulescens, and Streptomyces panayensis, respectively. Based on Liquid Chromatography Tandem-Mass Spectrometry (LC-MS/MS) analysis, two antibacterial compounds, namely rancimanycin III, and enteromycin were detected in all those three extracts. Interestingly, APM-21 extract also contained two prominent antibacterial substances including paramagnetoquinone C, and caerulomycin I, suggesting their contribution to the most potential activities. Moreover, new insights were provided into a promising candidate for use in an active compound combating strategy to control MDR bacterial strain infection.
Evaluation of Hursitism for Polycystic Ovary Syndrome Women At Al- Ramadi City
Authors: A.R. Alkubaisi , Aftan Al hayani Dhyauldeen , Subhi Noori Saif , Riyadh Abdul Kareem Al-Hetty Hussein
Published: November 2024

The hyper-androgen and huritism in face and body in women is important diseases. It can be used as a possible marker in patients with ovary polycystic syndrome (PCOS). This study was carried out to evaluate DHEA and Testosterone levels associated with huritism and PCOS was studied in serum samples from pregnant, and non-pregnant patients and controls attending clinic Specialized. The study included 38 samples divided into three groups: 21 patients subjects, 6 pregnant women, 15 non-pregnant women with PCOS syndrome, and 17 normal subjects as control of the same age group. The target  was selecting pregnant women due to changes in hormonal levels and physiological changes, as well as comparing them with non-pregnant women and control samples. The level of DHEAS was considerably higher in the median among pregnant women than in the control group and between non-pregnant and control groups without statistically significant differences between pregnant and non-pregnant values. Similarly, testosterone shows a statistically significant higher median among pregnant than control and also between non-pregnant and control groups without statistically significant difference between pregnant and non-pregnant values. In conclusion, this study detected a significant increase in testosterone and DHEA in non-pregnant women and then followed by pregnant women compared to the control, and age and the rise of these hormones are factors that cause the appearance of thick hair and thus cause polycystic ovary, which may lead to infertility.
Characterization of Antibacterial Compounds from Marine Sponge-associated Streptomyces spp. against Some Pathogenic Bacteria
Authors: Efendi Firda Sri , Budiarti Sri , Lestari Yulin
Published: November 2024

The increasing trend of antibiotic resistance among pathogenic bacteria is a worldwide problem. Streptomyces produce a number of bioactive compounds such as antibacterial. This study aimed to investigate the effect of different media and incubation time in increasing the antibacterial activity of marine sponge-associated Streptomyces spp. and characterize antibacterial compounds of marine sponge-associated Streptomyces spp. against pathogenic bacteria. Among the three tested media and some days of incubation times, Streptomyces spp. produce more antibacterial activity when grown using modified molasses medium at 15 days incubation. The ethyl acetate extracts of Dbi28t exhibited a significant inhibitory zone against Extended Spectrum β-Lactamase (ESBL)-producing Escherichia coli, Providencia rettgeri then followed by Proteus mirabilis and Pseudomonas putida and the results were higher than some commercial antibiotics. This study has identified nine antibacterial compounds in Dbi28t using Liquid Chromatography-tandem Mass Spectrometric (LC-MS/MS) analysis, with the most abundance belonging to pumilacidin A, then followed by pumilacidin B, surfactin B, surfactin A, phenazostatin B, chalcomycin B, neopyrrolomycin C, saquayamycin A and saphenamycin. This work provides the first report from a Streptomyces sp. Dbi28t produced pumilacidin, surfactin and other bioactive compounds with the modified molasses medium for optimization of characterization of its antibacterial compounds.
Independent prognostic value of lipocalin-2 in congenital heart disease-associated pulmonary artery hypertension
Authors: Guo Zhang-Ke , Chen Ping-Gui , Li Yao-Xuan , Jiao Hong , Kong Xiao-Hui , Bai Song , Li Xiao-Feng , Liu Ai-Jun , Wang Guo-Liang
Published: November 2024

BACKGROUND

Timely and accurate evaluation of the patient's pulmonary arterial pressure (PAP) is of great significance for the treatment of congenital heart disease. Currently, there is no non-invasive gold standard method for evaluating PAP.

AIM

To assess the prognostic value of lipocalin-2 (LCN2) in relation to PAP in patients with congenital heart disease associated with pulmonary artery hypertension.

METHODS

We conducted a retrospective analysis of 69 pediatric patients diagnosed with ventricular septal defects. The patients’ clinical and laboratory data were collected. The serum LCN2 concentrations were compared between the pulmonary arterial hypertension (PAH) group and the nonPAH group. The correlation of LCN2 concentration with PAH classification was evaluated using binary logistic regression analysis. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic potential of LCN2 for PAH.

RESULTS

Serum LCN2 concentration significantly correlated with patients’ mean PAP (r = 0.544, P < 0.001), but not correlated with creatinine (P = 0.446) or blood urea nitrogen (P = 0.747). LCN2 levels were significantly correlated with PAH in both univariate [odds ratio (OR) 1.107, 95%CI: 1.033-1.185, P = 0.004)] and multivariate regression analysis (OR 1.150, 95%CI: 1.027-1.288, P = 0.015). ROC curve analysis revealed an area under the curve of 0.783 for LCN2. At the cutoff value of 19.42 ng/mL, the sensitivity and specificity of LCN2 for diagnosing PAH is 90.19% and 55.56%, respectively. LCN2 concentration also significantly correlated with the post-repair mean PAP in patients with congenital heart disease (r = 0.532, P = 0.009).

CONCLUSION

LCN2 is emerging as a candidate biomarker for assessing PAP in patients with congenital heart disease. Its high sensitivity in diagnosing PAH makes it a valuable tool in patient management.
Role of a new inflammation predictor in predicting recurrence of atrial fibrillation after radiofrequency catheter ablation
Authors: Wang Yu-Jie , Liu Ke-Sen , Meng Xiang-Jiang , Han Xue-Fu , Nie Lu-Jing , Feng Wen-Jiu , Chen Yan-Bo
Published: November 2024

BACKGROUND

Radiofrequency catheter ablation (RFCA) has become an important strategy for treating atrial fibrillation (AF), and postoperative recurrence represents a significant and actively discussed clinical concern. The recurrence after RFCA is considered closely related to inflammation. Systemic immune inflammation index (SII) is a novel inflammation predictor based on neutrophils, platelets, and lymphocytes, and is considered a biomarker that comprehensively reflects the immune inflammatory status of the body.

AIM

To explore the predictive effect of the SII on AF recurrence after RFCA and its predictive value in combination with the existing APPLE score for AF recurrence after RFCA in patients with non-valvular AF (NVAF).

METHODS

We retrospectively included 457 patients with NVAF first receiving RFCA and classified them into the recurrent or non-recurrent group. We also investigated the predictive role of SII on AF recurrence following RFCA. Finally, we explored and compared the additional predictive value of the SII after combining with the APPLE score.

RESULTS

After 12 months of follow-up, 113 (24.7%) patients experienced recurrence. High SII has been demonstrated to be an independent predictor for postoperative AF recurrence. Receiver operating characteristic and decision curve analysis (DCA), as well as net reclassification improvement (NRI) and integrated discrimination improvement (IDI) results, showed that SII combined with the APPLE score had higher predictive efficiency than using the SII or APPLE score alone. The area under the curve of the combined model (0.662, 95% confidence interval: 0.602-0.722) significantly increased compared with that of the SII and APPLE scores alone (P < 0.001). The combined model resulted in an NRI of 29.6% and 34.1% and IDI of 4.9% and 3.5% in predicting AF recurrence compared with the SII and APPLE scores alone, respectively (all P < 0.001). The SII, APPLE score, and their combination demonstrated greater clinical utility than did the treat-all and treat-none strategies over the 20–80% risk threshold according to the DCA.

CONCLUSION

The SII was a predictor of recurrence after RFCA of AF. Moreover, the SII enhanced the predictability of the APPLE score for post-RFCA AF recurrence, providing valuable insights for physicians to optimise patient selection and develop personalised treatment plans.
Residents’ Exposure to Multiple Shocks and Coping Strategies among Tourism-Gateway Communities in Northern Tanzania
Authors: J. Mwongoso Alpha
Published: November 2024

There is increasing awareness about influence of tourism development on resident’s livelihoods. Yet, studies that link tourism and residents capabilities to withstand livelihood-shocks are scant. This study was set to address this empirical gap by evaluating the extent to which tourism development has enabled resident’s access to livelihood assets capable to address multiple livelihood-shocks through coping strategies. Retrospective evaluative technique embedded on multi-method approach was used to collect data, involving 63 in-depth interviews and survey among 416 tourism beneficiaries and 425 non-beneficiary agro-pastoral households in three gateway tourism destination communities of Northern Tanzania. It was found that residents have been exposed to severe multiple shocks in the facets of ecology (i.e. drought, livestock diseases and crop riding), economic (i.e. rise in food-price and business-loss), health (i.e. chronic illness and death) and social (i.e. family conflicts and cattle-theft). In response to the shocks, tourism beneficiary households used effective shock-coping strategies, such as spending on savings and livestock selling to address the shocks. On contrary, non-beneficiaries used less effective coping strategies like remittances and they reduce consumption. The study recommends increase access to resident’s financial and human resources in building greater capabilities to handle multiple livelihood-shocks.
Multimedia Features towards Skills Development in Open Learning: A Case of the Girls Inspire Project in Tanzania
Authors: Eliringia Mariki Belingtone
Published: November 2024

This study investigates the use of multimedia content for skills development in open learning, using the Girls Inspire Project in Tanzania as a case study. Conducted in the Chala and Msanzi Wards of the Rukwa Region, the study examined the multimedia features utilized in the project and their suitability within the context of open learning initiatives targeting marginalized communities in Tanzania. A qualitative approach was employed, incorporating documentary reviews and interviews with participants, including facilitators, multimedia production experts and project beneficiaries. The findings reveal that the multimedia contents used in the project were highly interactive and engaging, promoting active learner participation and effective skills development. Key multimedia features identified include high visibility, structured arrangement, varied content lengths tailored to lesson requirements and a balanced combination of media formats. These features were found to be highly suitable for the open learning context, as they enhanced accessibility and supported interactive learning for skills development, making them particularly effective for marginalized learners in remote areas. Despite the evidenced suitability of the multimedia learning contents, the study highlights the need for inclusion of more interactive elements and feedback mechanisms. The study further suggests that multimedia contents for future interventions should be tailored to meet specific needs of the target audience, considering local contexts, literacy levels and technological limitations. The study recommends future research to explore the long-term impact of multimedia learning on skills development and identify best practices for integrating multimedia features in similar development initiatives.
El liderazgo y la investigación como ejes en el desempeño docente en el Perú: perspectivas de estudiantes universitarios
Authors: Vega Garcia De Chauca Jenny Elizabeth , Olivos Jimenez Luis Marcelo , Olivos Jimenez Milagros Antonieta , Herrera Alamo Mirtha Soledad , Hernández Falla Jacqueline Victoria , Saenz Huamanchumo Arland Alex
Published: November 2024

El estudio fue desarrollado en la ciudad de Huaraz en una universidad privada, el cual consideró como propósito principal determinar el nivel de liderazgo e investigación como eje en el desempeño docente según la percepción de los estudiantes; contó con una población conformada por 560 estudiantes y una muestra de 228, fue desarrollado bajo el enfoque cuantitativo, de tipo básico y de alcance descriptivo; la técnica que se consideró para la recogida de datos fue la encuesta y el instrumento adecuado fue el cuestionario, para poder aplicar los instrumentos se tomó en cuenta a expertos los cuales validaron y aprobaron los instrumentos, asimismo se determinó que los instrumentos son confiables dado que los datos obtenidos muestran un alfa de Cronbach mayor a 0,75. En este estudio se consideró como objetivo específico: describir el nivel de liderazgo e investigación en el desempeño docente según sexo de los estudiantes, Examinar el impacto de las dimensiones del liderazgo en el desempeño docente, en una muestra de estudiantes universitarios de Huaraz, examinar el impacto de las dimensiones de investigación en el desempeño docente, en una muestra de estudiantes universitarios de Huaraz. Asimismo, se encontró como resultado la influencia del liderazgo e investigación en el desempeño docente.
Mapping of Noise Propagation in Quarries for Environmental Perspective
Authors: Çınar Ibrahim , Şensöğüt Cem
Published: November 2024

In this study noise measurements were made in a quarry belonging to a private, company located in the boundaries of Karaomerler village, Konya (Turkey). Noise levels were measured at 42 points, in the operation field and equivalent noise levels were determined and the results were mapped using NetCad program. With the help of the obtained noise maps, it is recommended to take preventive measures, where necessary. Proper reading of maps is crucial for effective and sufficient measures in terms of occupational health and safety measures have to be taken.
Retrieval of Land Surface Temperature of Lahore Through Landsat-8 TIRS Data
Authors: Nasar-u-Minallah Muhammad
Published: November 2024

Land surface temperature (LST) is an important parameter in global climate change and urban thermal environmental studies. The significance of land surface temperature is being acknowledged gradually and interest is increasing in developing methodologies for the retrieval of LST from Satellite Remote Sensing (SRS) data. Thermal Infrared Sensor (TIRS) of Landsat-8 is the newest TIR sensor for the Landsat Data Continuity Mission (LDCM), offering two adjacent thermal infrared bands (10, 11), having significant beneficiary for the land surface temperature inversion. The spectral radiance can be estimated through TIR bands 10 and 11 of Landsat-8 OLI_TIRS satellite image. In the present study, the radiative transfer equation-based method has been employed in estimating LST of Lahore and the analysis demonstrated that estimated LST has the highest accuracy from the radiative transfer method through band 10. Land Surface Emissivity (LSE) was derived with the aid of the NDVI’s threshold technique. The present study results show that as the built-up area increases and vegetation cover decreases in urban surface, they are linked to increase in urban land surface temperature and conversely larger vegetation cover associated with lower urban temperature. The output exposed that LST was high in built-up and barren land, whereas it was low in the area where there were more vegetation cover and water.
Applied regional studies: on gagauzian and bulgarian tracks to the phantom germans of albota de sus and alexanderfeld. An excursion report
Authors: ADELSGRUBER Paulus
Published: November 2024

The excursion described here was the conclusion of several years of work on the topic of "Bessarabian Germans" at the State Pedagogical University Ion Creangă in Chişinau. This included leading a research project on intercultural communication (in cooperation with the University of Regensburg, DiMOS), in which colleagues from Moldova, Ukraine and Germany participated. Interviews and historical (travel) texts were processed. In other contexts, the questions were recently extended to the Austrian settlements in the Romanian and Ukrainian Carpathians - for example through the screening of the documentary film "The Last Austrians" (2021) by Lukas Pitscheider in Chişinău, Băłti, Alexanderfeld and Comrat. The excursion to the south of the Republic of Moldova, conducted with Moldovan educators in June 2023, strengthened awareness of the historical and contemporary importance of the German language in the context of regional studies. At the same time, it offered new insights into the cultural life of other minorities - Bulgarians, Gagauz and Jews.
RADICAL SCAVENGING POTENTIAL OF DIFFERENT TYPES OF LIPOSOME PARTICLES WITH ENCAPSULATED CAROB EXTRACT
Authors: Dekanski Dragana , Raskovic Aleksandar ,   University of Novi Sad, Faculty of Medicine, Department of Pharmacology, Toxicology, and Clinical Pharmacology,  21000 Novi Sad, Serbia, Martić Nikola ,   University of Novi Sad, Faculty of Medicine, Department of Pharmacology, Toxicology, and Clinical Pharmacology,  21000 Novi Sad, Serbia, Pirkovic Andrea ,   Institute for the Application of Nuclear Energy INEP, University of Belgrade, Belgrade, Serbia, Jovanović Aleksandra ,   Institute for the Application of Nuclear Energy INEP, University of Belgrade, Belgrade, Serbia
Published: November 2024

Carob pulp extract contains bioactive phenolic compounds, making it a suitable functional food ingredient. This study aimed to investigate the radical scavenging potential of pure carob extract and different types of carob extract-loaded liposomes (multilamellar, UV-irradiated, and sonicated unilamellar vesicles). Their antioxidant capacity was measured by employing DPPH and ABTS assays. The encapsulation of carob extract within liposomes as well as UV irradiation and sonication did not cause a decrease in the anti-DPPH activity, however, the ABTS radical scavenging potential of pure extract was significantly lower compared to encapsulated counterparts. UV irradiation and sonication significantly decreased the anti-ABTS effect of the liposome with the extract. Carob pulp extract and its liposomal formulations displayed significant in vitro antioxidant potential that can be of interest for further development as a functional food ingredient or in the prevention/treatment of various diseases.
STAIR DESIGN AND FLOOR HEIGHT DIFFERENCES IN RELATION TO SAFETY CONCEPTS FOR ELEMENTARY SCHOOL STUDENTS
Authors: Muhammad Infaroyya Al Karimah , Sufianto Heru , Titisari Ema Yunita
Published: November 2024

The need for safe school buildings is further emphasized by the impact of natural disasters, which shows the importance of prioritizing investment in school infrastructure. This study aims to evaluate the suitability of the dimensions of the stairs with student anthropometry, regarding safety aspects in daily use, and provide design improvements to improve the safety of children in the school environment. This research is a descriptive-evaluative qualitative case study at SDN Ketawanggede from August 2023 to May 2024. Data were collected through observation, interviews, and document analysis. The results show that there are disparities in the implementation of safety and accessibility standards in schools with varying infrastructure conditions, focusing on both urban and rural areas, to identify disparities and best practices. The long-term impact of implementing safety measures, such as anti-slip materials, consistent step dimensions, and improved ramps, on the incidence of accidents and injuries among students, is analyzed. The practical outcome of this research includes actionable design solutions to mitigate safety hazards, particularly addressing differences in school floor heights and staircase dimensions. The study provides a valuable resource for policymakers, school administrators, and architects involved in designing and maintaining school facilities.
EVALUATION OF HOUSING FINANCING ASSISTANCE POLICIES FOR LOW-INCOME PEOPLE IN DKI JAKARTA
Authors: Khayrunnisa Fauzia Maurizka , Wijaya Chandra
Published: November 2024

This study aims to find out how to evaluate housing financing assistance policies for low-income people in the DKI Jakarta area. The research used a descriptive research design with a quantitative approach. The data collection technique used was a mixed method through respondent questionnaire surveys, interviews, and literature studies. The sample in this study consisted of respondents who had received the benefits of housing funding assistance policies and those who had not. The results of this study show that the leveling in the evaluation of housing finance assistance policies can be measured based on two indicators, namely, the policy has been evenly and comprehensively distributed, and the usefulness of the policy in overcoming the housing backlog in DKI Indonesia is felt by MBR. Meanwhile, from the utility aspect, the housing financing financing assistance policy is beneficial for MBR in acquiring subsidized houses. Furthermore, there are still shortcomings that must be corrected both from the supply aspect housing, strengthening policy monitoring and evaluation, strengthening governance and institutions, strengthening laws and regulations, strengthening collaboration and synergy between stakeholders, and strengthening collaboration. This study offers valuable insights for policymakers to design more equitable and sustainable housing financing strategies, addressing critical socio-economic issues in urban housing.
Bâbür İmparatoru II. Şah Âlem in Oğlu Mirza Civan Baht ın (Cihandar Şah), Büyük Britanya Kralı III. George a Mektubu
Authors: Meral Vedat
Published: November 2024

Bu çalışmada Bâbür imparatorlarından II. Şah Âlem'in büyük oğlu Mirza Civan Baht’ın
(Cihandar Şah), Büyük Britanya Kralı III. George’a yazdığı mektubun tercümesi yapılmıştır. Ayrıca,
mektubun tercümesinden önce Bâbürlüler ve II. Şah Âlem döneminin genel bir değerlendirmesine yer
verilmiştir. Diğer taraftan söz konusu mektubun, Bâbürlülerin çöküş sürecini yaşadığı 18. yüzyılın
sonlarında Hindistan’da egemen güç haline gelen İngilizler ve Marataların etkin nüfuzu altında saltanat
sürmek zorunda kalan II. Şah Âlem döneminde yazılmış olması, devletin, içinde bulunduğu durumu
yansıtması adına da önem arz etmektedir. Dolayısıyla bu makalenin esas muhteviyatını teşkil eden
mektubun tercümesine ilaveten, çalışmamızın bu bağlamda ele alınmış olmasıyla da daha sonra benzer
konularda yapılacak olan bilimsel araştırmalara katkıda bulunulması umulmaktadır