bluuebunny/crossref_metadata_2025 huggingface dataset:
Agenda Setting and Political Control in India’s Sanitation Policy Subsystem
Authors: Martel J.C.
Published: September 2017

India has the worst sanitation situation in the world. Over the past century, Indian political leaders have made public statements expressing the intensity of the problem, deeming sanitation more important than political freedom, independence and religion. Recently, two prominent political parties—National Congress and Bharatiya Janata—argued about who deserves credit for improving India’s cleanliness. In response, this article is guided by the question: Does it matter which political institutions are supporting sanitation improvements in India? Using two theoretical lenses, agenda setting and political control of bureaucracy, this article discusses (1) the problem, politics and policies in India’s sanitation policy subsystem, and (2) mechanisms to align policy preferences across levels of government. Utilizing an agenda setting conceptual framework, the discussion highlights the role of international organizations in problem identification; party ideology and values and capacity issues that challenge the policy arena. The discussion turns to alignment of policy preferences across India’s multi-level governance structure, pointing to monitoring to reduce principal-agent problems, drawing from political control of bureaucracy theory. Given that national political leaders observably support sanitation, this article proposes that aligning policy preferences between national political institutions and local implementation agencies is imperative for achieving sanitation policy goals in federalist India.
Informational Videos About Alcohol Use: Feasibility and Acceptability
Authors: Brager Jenna , Rodney Tamar , Finnell Deborah
Published: September 2017

Background: An estimated 15.1 million adults ages 18 years and older are classified with an alcohol use disorder, which includes 9.8 million men and 5.3 million women. A brief intervention is indicated for those identified to be at risk because of alcohol use. Objective: To determine the feasibility and acceptability of informational videos about alcohol use. Design: This feasibility study provided participants with the opportunity to choose one of two videos, Alcohol and the Brain or Rethinking Drinking. An online survey was administered to all study participants to identify alcohol-related risk, readiness to decrease use, and knowledge pertaining to alcohol use. Results: The two videos provided in this study were feasibly delivered in an on-line format to 129 adults, including 115 males and 5 females identified to be at risk. Knowledge scores increased only slightly. There were mixed results for the readiness scores. Conclusions: Future research should examine the efficacy of these two alcohol brief interventions on alcohol-related outcomes.
Clinical and Dermoscopic Features of Pigmented Disseminated Superficial Actinic Porokeratosis: Case Report and Literature Review
Authors: Sotoodian Bahman , Mahmood Muhammad N. , Salopek Thomas G.
Published: September 2017

Introduction:

Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally.

Case Presentation:

We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin.

Literature Review and Conclusion:

A thorough review of PubMed failed to identify any previous reports on the dermoscopic appearance of pigmented porokeratosis. On dermoscopy, the presence of black dots limited to the periphery of the lesions is due to pigment incontinence and melanophages within the superficial papillary dermis limited to the area below the cornoid lamella. Pigmented DSAP is a unique morphological presentation of porokeratosis, and it is essential to be familiar with its clinical and dermoscopic presentation.
‘It’s a Profession, it Isn’t a Job’: Police Officers’ Views on the Professionalisation of Policing in England
Authors: Lumsden Karen
Published: September 2017

This article focuses on police officers’ views on the professionalisation of policing in England against a backdrop of government reforms to policing via establishment of the College of Policing, evidence-based policing, and a period of austerity. Police officers view professionalisation as linked to top-down government reforms, education and recruitment, building of an evidence-base, and ethics of policing (Peelian principles). These elements are further entangled with new public management principles, highlighting the ways in which professionalism can be used as a technology of control to discipline workers. There are tensions between the government’s top-down drive for police organisations to professionalise and officers’ bottom-up views on policing as an established profession. Data are presented from qualitative interviews with 15 police officers and staff in England.
Using GPS Geo-tagged Social Media Data and Geodemographics to Investigate Social Differences: A Twitter Pilot Study
Authors: Chappell Paul , Tse Mike , Zhang Minhao , Moore Susan
Published: September 2017

This article outlines a new method for investigating social position through geo-tagged Twitter data, specifically through the application of the geodemographic classification system Mosaic. The method involves the identification of a given tweeter’s likely location of residence from the ‘geo-tag’ attached to their tweet. Using this high-resolution geographic information, each individual tweet is then attributed a geodemographic classification. This article shows that the specific application of geodemographics for discerning between different types of tweeters is problematic in some ways, but that the general process of classifying tweeters according to their position in geographical space is viable and represents a powerful new method for discerning the social position of tweeters. Further research is required in this area, as there is great potential in employing the mobile global positioning system data appended to digital by-product data to explore the intersections between geographical space and social position.
The Sexual Use of a Social Networking Site: The Case of Pup Twitter
Authors: Wignall Liam
Published: September 2017

This article examines how Twitter has been adopted and used by a sexual subculture in distinct ways. Drawing on interviews with 26 gay and bisexual men based in the UK who identify as ‘pups’, it demonstrates how a kinky sexual subculture exists on a social networking site in new and innovative ways, adapting various elements of Twitter to form a unique subculture that I call ‘Pup Twitter’. Engaging with debates about social trends related to sexuality, as well as contemporary understandings of social networking sites, the study documents how this subcultural sexual community, while predating Twitter, has adopted online methods to enhance communication, engagement, and even visibility. The intersection of sexuality and social networking sites is an area ripe for further study, and this article develops empirical and conceptual ways to examine this issue in the future.
Transcatheter Aortic Valve Implantation as a Bailout Procedure for Acute Aortic Valve Regurgitation During Endovascular Arch Repair
Authors: Hertault Adrien , Clough Rachel E. , Modine Thomas , Auffray Jean-Luc , Koussa Mohamad , Haulon Stéphan
Published: September 2017

Purpose: To report emergent transcatheter aortic valve implantation (TAVI) to treat acute severe aortic regurgitation caused by valve cusp dysfunction following proximal migration of an endograft implanted in the ascending aorta during endovascular arch repair. Case Report: A 65-year-old man had been previously treated with thoracic and fenestrated endografts in a 2-stage procedure for a chronic type B dissection. At 2-year follow-up, aneurysmal evolution of the distal arch led to development of a proximal type Ia endoleak. The patient was deemed unfit for open repair because of severe nonrevascularizable coronary artery disease. A custom-made endograft was designed consisting of a double inner branch arch endograft with a proximal component to reline the ascending aorta to avoid iatrogenic type A dissection. The first component was successfully deployed. However, this device migrated toward the aortic valve when the delivery system of the branch device was advanced through the aortic valve. Aortography and transesophageal echography showed acute aortic regurgitation due to obstruction of the left coronary valve cusp. An emergency bailout TAVI procedure was performed to successfully treat the aortic regurgitation. Conclusion: TAVI can be used as a bailout procedure for acute aortic valve dysfunction during endovascular arch or ascending aorta repair.
Histological Evaluation of a Self-Expanding Stent-Graft 23 Months After Implantation in the Superficial Femoral Artery
Authors: Ishihara Takayuki , Iida Osamu , Inoue Katsumi , Fujita Masashi , Masuda Masaharu , Okamoto Shin , Nanto Kiyonori , Kanda Takashi , Tsujimura Takuya , Sunaga Akihiro , Mano Toshiaki , Uematsu Masaaki
Published: September 2017

Purpose: To report histological examination of a Viabahn stent-graft implanted in the superficial femoral artery (SFA) for nearly 2 years. Case Report: A 78-year-old man with peripheral artery disease was treated successfully with a 6.0×250-mm Viabahn self-expanding stent-graft in the right SFA, relieving his lower limb claudication. The patient died suddenly due to acute myocardial infarction 23 months later. Histological evaluation of the stent-graft implantation site revealed moderate neointimal proliferation at both proximal and distal edges of the device. In the middle part of the stent, significant macrophages and multinucleated foreign body giant cells had accumulated, although the stent was entirely patent. Furthermore, no endothelial cell coverage was found. Conclusion: Judging from these features, it might be necessary to continue dual antiplatelet therapy after stent-graft implantation over the long term to prevent thrombosis and subsequent restenosis or reocclusion.
Pivotal Study of a Next-Generation Balloon-Expandable Stent-Graft for Treatment of Iliac Occlusive Disease
Authors: Bismuth Jean , Gray Bruce H. , Holden Andrew , Metzger Christopher , Panneton Jean ,   on behalf of the VBX FLEX Study Investigators
Published: September 2017

Purpose: To evaluate the safety and efficacy of a next-generation balloon-expandable stent-graft for the treatment of arterial occlusive disease in patients with de novo or restenotic lesions in the common and/or external iliac arteries. Methods: A prospective, multicenter, single-arm safety and efficacy study ( ClinicalTrials.gov identifier: NCT02080871) of the VBX Stent Graft for treatment of de novo or restenotic lesions in the iliac arteries was conducted under an Investigational Device Exemption at 26 US sites and 1 New Zealand center. The study eligibility criteria were established with the aim of enrolling more “real-world” patients compared with previous iliac stent studies supporting Food and Drug Administration approval. The study enrolled 134 patients (mean age 66±9.5 years; 79 men) with 213 iliac lesions. Three-quarters of the population (101, 75.4%) had Rutherford category 3 ischemia, and 43 (32.1%) patients presented with TASC II C/D lesions. The primary endpoint was a composite of device- or procedure-related death within 30 days, myocardial infarction within 30 days, target lesion revascularization (TLR) within 9 months, and amputation above the metatarsals in the treated leg within 9 months. Results: In all, 234 devices were implanted in 213 lesions with 100% technical success; 57 (42.5%) patients received kissing stents at the aortic bifurcation. No devices exhibited a discernable change in length after final deployment as determined by independent core laboratory quantitative angiographic analysis. At 9 months, 3 (2.3%) of 132 patients (1 lost to follow-up, 1 unrelated death) experienced a major adverse event (3 TLRs) related to the primary endpoint. At 9 months, there were no device-related serious adverse events or unanticipated adverse device effects. Conclusion: The next-generation balloon-expandable stent-graft demonstrated notable 9-month safety and efficacy in treating iliac occlusive disease in patients reflecting common clinical practice.
The impact of media and NGOs on four European Parliament discourses about conflicts in the Middle East
Authors: Herrero-Jiménez Beatriz , Arcila Calderón Carlos , Carratalá Adolfo , Berganza Rosa
Published: September 2017

There is empirical evidence of media influence on parliamentary agenda, especially when media coverage privileges conflict framing of reality and negativity. This article addresses the impact of media presence (traditional and social media) and NGOs on European parliamentary discussions about violent conflicts in the Middle East and their role during phases of escalation and pacification. The authors content analysed 7,633 minutes from debates involving the Syrian (from January 2011 to June 2015) and Israeli–Palestinian (from March 2006 to June 2015) conflicts, from the European Parliament ( N = 2,541), the German Bundestag ( N = 2,138), the UK House of Commons ( N = 2,514) and the French Assemblée Nationale ( N = 440). Conflict-related paragraphs were filtered and analysed. Using the multilingual and cross-validated dictionary adapted to conflict and media analysis created by INFOCORE, they measured the presence of media and actors as well as the inclusion of conflict-key concepts within parliamentary discussions. Findings revealed that social media (when compared to traditional media and NGOs) are the main actors quoted in parliamentary minutes when they refer to violent conflicts and that this attention varies over time and is driven by focusing events. The presence of traditional and social media as well as NGOs in the debates was significantly different depending on the parliament studied and the conflict under consideration. The authors found empirical evidence supporting the claim that such concepts as limited violence, crisis, assistance and pacification are correlated with the presence of media and NGOs.
Sex, Drugs, and Reckless Driving
Authors: Morgenroth Thekla , Fine Cordelia , Ryan Michelle K. , Genat Anna E.
Published: September 2017

We investigated whether risk-taking measures inadvertently focus on behaviors that are more normative for men, resulting in the overestimation of gender differences. Using a popular measure of risk-taking (Domain-Specific Risk-Taking) in Study 1 ( N = 99), we found that conventionally used behaviors were more normative for men, while, overall, newly developed behaviors were not. In Studies 2 ( N = 114) and 3 ( N = 124), we demonstrate that differences in normativity are reflected in gender differences in self-reported risk-taking, which are dependent on the specific items used. Study 3 further demonstrates that conventional, masculine risk behaviors are perceived as more risky than newly generated, more feminine items, even when risks are matched. We conclude that there is confirmation bias in risk-taking measurement.
Ultrasound-guided radiofrequency ablation of genicular nerves of knee for relief of intractable pain from knee osteoarthritis: a case series
Authors: Ahmed Arif , Arora Divesh
Published: September 2017

Introduction:

The knee arthroplasty is the best option for patients with advanced osteoarthritis who have failed all other conservative options, but regrettably many patients fail to undergo surgery due to co-morbidities or other reasons. So, new alternative modes are always in demand for these patients.

Methods:

The ultrasound-guided radiofrequency ablation (RFA) of all the genicular nerves of knee joint was done in patients with grade III and IV osteoarthritis of knee joint, with severe pain (numerical rating scale (NRS) > 7) who had failed conservative management and intra-articular injections after a positive genicular nerve block with local anaesthetics. The demographics, pain intensity measured in NRS, Oxford Knee Score (OKS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and quality of life measured by 36-Item Short Form Health Survey (SF-36) questionnaire was measured at baseline and at regular intervals.

Results:

The average age of the patients was 61.50 ± 6.75 years. There was significant improvement in pain intensity at rest, movement and on weight bearing from 8.75 ± 0.5, 9.0 ± 0.0, and 9.0 ± 0.0 at baseline to 2.38 ± 0.51, 3.75 ± 0.46, and 4.13 ± 0.35 at 1 month and 3.13 ± 0.64, 4.38 ± 0.51, and 4.63 ± 0.51 at 6 months after the procedure, respectively (p value <0.05). The OKS had improved from 7.75 ± 1.25 at baseline to 28.88 ± 2.53 and 28.13 ± 1.80 at 1 and 6 months, respectively, after the procedure (p value <0.05). The WOMAC score had also improved significantly from 77.75 ± 4.34 at baseline to 38.38 ± 5.82 and 39.25 ± 5.12 at 1 and 6 months, respectively (p value <0.05). There was also significant improvement in the quality of life after the procedure (p value <0.05).

Conclusion:

Ultrasound-guided RFA of genicular nerves of knee joint is a good alternative option for patients who are having severe pain and disability from knee osteoarthritis and gives a long-lasting pain relief for more than 6 months.
Single-pedicle hinge flap performed by shelter medicine team resolves chronic antebrachial wound in a cat
Authors: Richardson Jodi M , Shivley Jacob M , Bushby Philip A
Published: September 2017

Case summary

An approximately 3-year-old, male domestic longhair cat was presented to a mobile veterinary unit for routine neuter. Preoperative physical examination revealed an approximately 5 cm × 2 cm scab on the craniolateral portion of the left antebrachium. The cat was anesthetized for the neuter using an injectable anesthesia protocol. After castration, the wound area on the antebrachium was clipped, copiously lavaged and the wound edges were surgically debrided. Injectable antibiotics and analgesic management were instituted. The wound was conservatively managed using sugar bandaging and antibiotic dressings until the progression of healing plateaued. Procedures for closing the defect were explored, and it was decided that a single-pedicle hinge flap would be ideal. The procedure was performed on the mobile veterinary unit and managed postoperatively with pain control and biweekly bandage changes. After 3 weeks, the single-pedicle hinge flap was released to create a skin graft, which successfully filled the defect.

Relevance and novel information

Single-pedicle hinge flaps performed in feline patients have been minimally reported. This case report serves to provide detailed information on the surgical procedure and aftercare required for a successful outcome. Furthermore, this procedure was performed by a shelter medicine team in a mobile veterinary unit with no specialty equipment or instruments. This report documents an alternative procedure that may be used in a shelter environment for distal forelimb wounds rather than amputation or euthanasia.
CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis
Authors: Münzer Patrick , Walker-Allgaier Britta , Geue Sascha , Langhauser Friederike , Geuss Eva , Stegner David , Aurbach Katja , Semeniak Daniela , Chatterjee Madhumita , Gonzalez Menendez Irene , Märklin Melanie , Quintanilla-Martinez Leticia , Salih Helmut R. , Litchfield David W. , Buchou Thierry , Kleinschnitz Christoph , Lang Florian , Nieswandt Bernhard , Pleines Irina , Schulze Harald , Gawaz Meinrad , Borst Oliver
Published: September 2017

Key Points

CK2β is critically required for thrombopoiesis by regulating tubulin polymerization, MK fragmentation, and proplatelet formation. CK2β facilitates inositol triphosphate–mediated increase of cytosolic Ca2+ and is essential for platelet activation in arterial thrombosis in vivo.
Pain control in thoracic oncology
Authors: Peeters-Asdourian Christine , Massard Gilbert , Rana Paragi H. , Van Houtte Paul , White Andrew P. , Grigoriu Bogdan , Lossignol Dominique , Almalki Mohammed , Alexiou Jean , Engelholm Jean-Luc , Sculier Jean-Paul
Published: September 2017

This review of pain management in lung cancer is based on the presentation of four cases of thoracic oncology patients with pain at various stages of their disease. The approach will be multidisciplinary, involving a thoracic oncologist, radiologist, thoracic and orthopaedic spine surgeon, radiation therapist, pain medicine specialist, and palliative care specialist. This multispecialty approach to the management of different painful presentations in thoracic oncology will demonstrate the complexity of each case and the improved patient outcomes which result from the involvement of different disciplines working in concert.

In the USA, Europe and other countries, palliative care specialists often become rapidly involved in the management of these patients, coordinating social care and providing psychological support.

Thoracic and orthopaedic spine subspecialists provide surgical methods to control tumour invasion, and improve quality of life and preservation of function in settings of even diffuse metastatic disease. Similarly, thoracic oncology and radiation therapists utilise both therapeutic and palliative chemotherapeutic and radiation therapy regimens to prolong and improve quality of life.

The pain medicine specialist can, in addition to medication management, offer a variety of interventional approaches including unique drug delivery systems such as epidural analgesia, regional anaesthesia techniques, and intrathecal pumps, as well as neuromodulation techniques and neurolytic or neuroablative procedures.

In the USA, these specialists complete an additional fellowship year in pain medicine following the completion of an anaesthesiology, physical medicine and rehabilitation, neurology or psychiatry residency. These programmes are accredited by the Accreditation Council for Graduate Medical Education, or ACGME (www.acgme.org).
Case study on 3D printing education in fashion design coursework
Authors: Kwon Yu Mi , Lee Young-A , Kim Sook Jin
Published: September 2017

In the past 10 years, the use of 3D printing (3DP) has been increased in a number of industries. However, its use in the fashion industry and education is still at the early stage. This study aimed to provide (1) a general overview of 3DP in fashion and its integration in fashion education and (2) a pedagogical guidance to educators in the fashion discipline by presenting one case of 3D printing education in fashion design courses. This case study focused on the importance of 3D printing in fashion design curricula and the way to strategically integrate this technology into the curriculum. Rhinoceros (Rhino) and FINEBOT were used for 3D object design and printing, respectively. The coursework consisted of theoretical lectures including definition and application of 3D printing; training of Rhino use; methods of producing objects; 3D modeling of creative objects; and 3D printing practice. During this coursework, the course instructor allowed for students to initiate their design and create the 3D objects on what they wanted. Challenges for educators were identified when fashion students were learning 3D modeling software; however, the coursework resulted in increased interest and understanding of the students in 3D modeling and printing of more advanced fashion-related objects.
Illness perceptions in adolescents with a psychiatric diagnosis in Pakistan
Authors: Imran Nazish , Azeem Muhammad Waqar , Chaudhry Mansoor R. , Butt Zeeshan
Published: September 2017

Aims and method

To assess adolescents' perceptions of their psychiatric illness and the role of various demographic factors in a Pakistani setting. Adolescents with various psychiatric diagnoses were interviewed using a structured questionnaire including the Illness Perceptions Questionnaire–Revised (IPQ-R).

Results

Fifty-two adolescents with various psychiatric illnesses were interviewed; their mean age was 12.7 years and the majority (67%) were female. Males had significantly higher scores on timeline and emotional representation (P<0.05), suggesting strongly held beliefs about chronicity of their illness and anger and worry about their condition. Adolescents' own emotional state, stress, family problems and bad luck were endorsed by participants as some of the causal factors in their mental illness.

Clinical implications

Despite the importance of early intervention in psychiatric problems, engaging youth in the treatment process in Pakistan remains difficult. Better understanding of how adolescents perceive their psychiatric difficulties may play a significant role in developing culturally sensitive interventions and better utilisation of services.
‘Spirituality’ and ‘cultural adaptation’ in a Latino mutual aid group for substance misuse and mental health
Authors: Anderson Brian T. , Garcia Angela
Published: September 2017

A previously unknown Spanish-language mutual aid resource for substance use and mental health concerns is available in Latino communities across the USA and much of Latin America. This kind of ‘4th and 5th step’ group is a ‘culturally adapted’ version of the 12-step programme and provides empirical grounds on which to re-theorise the importance of spirituality and culture in mutual aid recovery groups. This article presents ethnographic data on this organisation.
Effectiveness of model-based clustering in analyzing Plasmodium falciparum RNA-seq time-course data
Authors: Oyelade Jelili , Isewon Itunuoluwa , Olaniyan Damilare , Rotimi Solomon O , Soyemi Jumoke
Published: September 2017

Background: The genomics and microarray technology played tremendous roles in the amount of biologically useful information on gene expression of thousands of genes to be simultaneously observed. This required various computational methods of analyzing these amounts of data in order to discover information about gene function and regulatory mechanisms.

Methods: In this research, we investigated the usefulness of hidden markov models (HMM) as a method of clustering Plasmodium falciparum genes that show similar expression patterns. The Baum-Welch algorithm was used to train the dataset to determine the maximum likelihood estimate of the Model parameters. Cluster validation was conducted by performing a likelihood ratio test.

Results: The fitted HMM was able to identify 3 clusters from the dataset and sixteen functional enrichment in the cluster set were found. This method efficiently clustered the genes based on their expression pattern while identifying erythrocyte membrane protein 1 as a prominent and diverse protein in P. falciparum.

Conclusion: The ability of HMM to identify 3 clusters with sixteen functional enrichment from the 2000 genes makes this a useful method in functional cluster analysis for P. falciparum
O edifício da Biblioteca Geral da Universidade de Coimbra (1936-1956)
Authors: Da Costa João Pedro Cardoso Gomes
Published: September 2017

Este texto foi escrito como um contributo para a monografia Os Livros em sua ordem. Coimbra : Imprensa da Universidade, 2014, comemorativo dos 500 anos da Biblioteca da Universidade de Coimbra, e cobre o período relativo à construção do novo edifício da Biblioteca Geral. Como foi muito adaptado para aquela edição, republica-se aqui na sua versão original.
Collapse characteristics of a circular-cross-section CFRP pipe structure member using finite element analysis
Authors: Kim Dae Young , Kim Hee Seong , Kim Ji Hoon
Published: September 2017

Carbon fiber reinforced plastics (CFRPs) are advanced composite materials that have been used as lightweight structural materials for vehicles. Unlike general isotropic materials, the structural characteristics of composite materials are strongly influenced by the stacking directions and sequences of the composite laminates. In this study, finite element analysis was used to predict the material properties of the carbon fibers and the resin composing a CFRP in cases of laminated carbon fibers and modified external angles. The results verify the approach’s reliability by comparing the simulation results and the real test results related to the material properties of the carbon fibers and the resin. The results of the finite element analysis and the experimental results were compared with the load-displacement curves and the maximum load. The [02/902]S, [902/02]2, and [0/90]2S specimens showed a maximum error rate of 8.6%, whereas the [902/02]S, [02/902]2, and [90/0]2S specimens showed a maximum error rate of approximately 12.93%. By applying CFRP static collapse analysis of fiber properties and resin properties through basic experiments and basic theory, we predicted the properties of CFRPs through finite element analysis; an error rate of approximately 10% indicated that our approach is effective.
Maternal plasma LPCAT 1 mRNA correlates with lamellar body count
Authors: Welch Robert A. , Recanati Maurice-Andre , Welch Kathryn C. , Shaw Michael K.
Published: September 2017

Human lysophosphatidylcholine acyltransferase 1 (hLPCAT1) is a protein which helps produce surfactant in the fetal lung. We previously reported that levels of cell-free fetal mRNA for hLPCAT1 in amniotic fluid are correlated with lamellar body count (LBC) (r2=0.93). This short communication demonstrates that fetal hLPCAT1 mRNA is also present in maternal blood. Its quantity also correlates with amniotic fluid LBC (r2=0.81). Research in maternal plasma hLPCAT1 may assist in understanding fetal and placental maturational processes.
Kant on Modalities and Justification
Authors: Osborne Nicolas
Published: September 2017

This paper studies the Kantian conception of modality of judgement. After making some general considerations about the text following the table of the forms of judgement, I will take an historical perspective which will point out that the central concept for the definition of the modality of judgement is the copula. Then, after explaining the distinction between two conceptions of the copula, namely the formal conception and the transcendental one, I will argue for the second one. Finally, I will define each of the three modalities of judgement in relation to the justification the judger is able to give for her judgement.
Mendelssohn’s Refutation of Kant’s Critique of the Ontological Proof
Authors: Rovira Rogelio
Published: September 2017

In his
Organomonophosphanes in PtP2X2 (X=Br, I, SeL, SiL or TeL): structural aspects
Authors: Melník Milan , Mikuš Peter , Krajčiová Dominika
Published: September 2017

This review includes more than 100 monomeric derivatives in which the Pt(II) atom is in a distorted square planar environment with inner coordination spheres of PtP
Efficacy of Art Therapy in Individuals With Personality Disorders Cluster B/C: A Randomized Controlled Trial
Authors: Haeyen Suzanne , van Hooren Susan , van der Veld William , Hutschemaekers Giel
Published: September 2017

Multidisciplinary treatment programs for patients with personality disorders (PDs) often include art therapy, but the efficacy of this intervention has hardly been evaluated. The objective of this study is to evaluate the effects of an art therapy intervention on psychological functioning of patients with a PD. In this randomized controlled trial, 57 adult participants diagnosed with a PD cluster B/C (SCID-II) were randomly assigned to either weekly group art therapy (1.5 hours, 10 weeks) or a waiting list group. Outcome measures OQ45, AAQ-II, and SMI were assessed at baseline, at post-test (10 weeks after baseline), and at follow-up (5 weeks after post-test). The results show that art therapy is an effective treatment for PD patients because it not only reduces PD pathology and maladaptive modes but it also helps patients to develop adaptive, positive modes that indicate better mental health and self-regulation.
Circulating steroid hormone variations throughout different stages of prostate cancer
Authors: Snaterse Gido , Visser Jenny A , Arlt Wiebke , Hofland Johannes
Published: September 2017

Steroid hormones play a central role in the maintenance and progression of prostate cancer. The androgen receptor is the primary driver of tumor cell proliferation and is activated by the androgens testosterone and 5α-dihydrotestosterone. Inhibition of this pathway through medical or surgical castration improves survival in the majority of advanced prostate cancer patients. However, conversion of adrenal androgen precursors and alternative steroidogenic pathways have been found to contribute to tumor progression and resistance to treatment. The emergence of highly accurate detection methods allows us to study steroidogenic mechanisms in more detail, even after treatment with potent steroidogenic inhibitors such as the CYP17A1 inhibitor abiraterone. A clear overview of steroid hormone levels in patients throughout the local, metastatic and castration-resistant stages of prostate cancer and treatment modalities is key toward a better understanding of their role in tumor progression and treatment resistance. In this review, we summarize the currently available data on steroid hormones that have been implicated in the various stages of prostate cancer. Additionally, this review addresses the implications of these findings, highlights important studies in this field and identifies current gaps in literature.
Body Shape and Coloration of Silkworm Larvae Are Influenced by a Novel Cuticular Protein
Authors: Xiong Gao , Tong Xiaoling , Gai Tingting , Li Chunlin , Qiao Liang , Monteiro Antónia , Hu Hai , Han Minjin , Ding Xin , Wu Songyuan , Xiang Zhonghuai , Lu Cheng , Dai Fangyin
Published: September 2017

Body shape and color patterns of insect larvae are fundamental traits for survival. Typically, transcription factors or members of signaling pathways...

The genetic basis of body shape and coloration patterns on caterpillars is often assumed to be regulated separately, but it is possible that common molecules affect both types of trait simultaneously. Here we examine the genetic basis of a spontaneous cuticle defect in silkworm, where larvae exhibit a bamboo-like body shape and decreased pigmentation. We performed linkage mapping and mutation screening to determine the gene product that affects body shape and coloration simultaneously. In these mutant larvae we identified a null mutation in BmorCPH24, a gene encoding a cuticular protein with low complexity sequence. Spatiotemporal expression analyses showed that BmorCPH24 is expressed in the larval epidermis postecdysis. RNAi-mediated knockdown and CRISPR/Cas9-mediated knockout of BmorCPH24 produced the abnormal body shape and the inhibited pigment typical of the mutant phenotype. In addition, our results showed that BmorCPH24 may be involved in the synthesis of endocuticle and its disruption-induced apoptosis of epidermal cells that accompanied the reduced expression of R&R-type larval cuticle protein genes and pigmentation gene Wnt1. Strikingly, BmorCPH24, a fast-evolving gene, has evolved a new function responsible for the assembly of silkworm larval cuticle and has evolved to be an indispensable factor maintaining the larval body shape and its coloration pattern. This is the first study to identify a molecule whose pleiotropic function affects the development of body shape and color patterns in insect larvae.
ANÁLISE DE ROTA DE PENEIRAMENTO DE MINÉRIO DE FERRO NO ITM DA NAMISA S.A – UM ESTUDO DE CASO
Authors: De São José Fábio , Teixeira Junior Mauro Lúcio , Pereira Carlos Alberto
Published: September 2017

O mercado mundial de minério de ferro iniciou nova recuperação na década de 2000, diante de um ciclo de expansão, chegou a atingir ritmo acelerado de 70% de crescimento anual. Fato que viabilizou inúmeros projetos de mineração, principalmente no Brasil, nos quais jazidas antes desvantajosas economicamente passaram a empreendimentos de valor agregado. Dessa forma, pesquisas em todos os setores e áreas do processamento mineral intensificaram-se na busca por excelência. No peneiramento, entendido como separação de sólidos em classes de tamanho e forma dos constituintes e no uso de gabaritos (por exemplo, peneiras), também houve procura por maior eficiência industrial. Assim, este trabalho investigou pontos de possíveis melhorias no peneiramento de uma mineradora de grande porte, exportadora de minério de ferro, localizando pontos de maximização do processo/operação. Entre os principais resultados destacam-se eliminação de sobrecarga no peneiramento primário pela substituição da abertura/malha do primeiro deck de 40 para 30 mm com retido destinado à britagem secundária, troca da malha do segundo deck de 30 para 5 mm com retido enviado para peneiramento secundário e eliminação de finos no peneiramento primário pela adição de água na britagem secundária.
CONCENTRAÇÃO DE METAIS EM SEDIMENTOS DA LAGOA DO PARQUE METROPOLITANO DE PITUAÇU, SALVADOR, BAHIA, BRASIL
Authors: Silva Edevaldo , Souza Niere Fernanda Almeida , Viana Zenira Cardoso Vilasboas , Marinho Philipe Silva Silva , Santos Vera Lúcia Cancio Souza
Published: September 2017

A lagoa de Pituaçu está inserida no Parque Metropolitano de Pituaçu (PMP). Esta recebe efluentes domésticos e pluviais e encontra-se em um processo acelerado de degradação ambiental. O presente trabalho teve como objetivo determinar a concentração de metais pesados (Al, Cu, Fe, Mn, V) em sedimentos superficiais da lagoa do Parque Metropolitano de Pituaçu, Salvador, Bahia, Brasil. Foram definidos 7 pontos amostrais. A determinação de metais (Al, Cu, Fe, Mn e V) foi realizada utilizando a técnica da espectrometria de emissão óptica com plasma indutivamente acoplado (ICP OES). A faixa de concentrações encontradas para os metais foram: Al (3.618-27.210 mg kg-1); Fe (11.968-122.030 mg kg-1); Mn (44,00-481,50 mg kg-1); V (25,00-111,50 mg kg-1) e Cu (4,05-25,50 mg kg-1). A ordem de concentração nos diversos pontos foi Fe>Al>Mn>V>Cu ou Fe>Al>Mn=V>Cu, com as maiores e as menores concentrações de todos os metais, encontradas nos pontos P1 e P3, respectivamente. Houve variações espaciais nas concentrações dos metais, com maiores concentrações nos pontos amostrais próximos de atividades antrópicas (efluentes e atividade agrícola). Esse estudo reporta níveis relativamente altos, especialmente para o V, indicando possíveis necessidades de ampliar ações de preservação ou monitoramento ambiental para evitar a acumulação desses metais em níveis tóxicos para a água e para o sedimento.
A CONSERVAÇÃO DAS VARIEDADES CRIOULAS PARA A SOBERANIA ALIMENTAR DE AGRICULTORES: ANÁLISE PRELIMINAR DE CONTEXTOS E CASOS NO BRASIL E NO MÉXICO
Authors: Pereira Viviane Camejo , López Pedro Antonio , Dal Soglio Fabio Kessler
Published: September 2017

Este estudo discute três iniciativas para a conservação das variedades crioulas promovendo a soberania alimentar de famílias agricultoras e camponesas no Brasil e no México. Por meio de entrevistas e de observação participante menciona-se os programas de Guardiões de Sementes Crioulas no Rio Grande do Sul, o Banco Comunitário de Sementes na Paraíba, Brasil e o Programa de Custódios do Milho Crioulo no estado de Puebla no México como iniciativas que fomentam com que os agricultores conservem os recursos fitogenéticos em suas próprias propriedades com prioridade para aqueles que são mais consumidos pela família e na propriedade rural. As iniciativas configuram-se como fomento a soberania alimentar das famílias conservando a agrobiodiversidade e garantindo o reconhecimento aos agricultores guardiões e custódios. Além disso conferem  autonomia produtiva e alimentar como por meio dos bancos de sementes em que os próprios agricultores gerenciam a armazenagem. A união entre agricultores e mediadores como a extensão rural e a acadêmica e o Estado são essenciais para o fomento e eficácia dos programas para a conservação das variedades crioulas como estratégia para a soberania alimentar das comunidades rurais.
High Efficiency Transformation Protocol using NEB 10-beta Competent E. coli (C3019I) v2
Authors: England Biolabs New
Published: September 2017

This is the correct protocol if you are using the C3019I cells. If you are using the C3019H cells, please refer to this protocol.
High Efficiency Transformation Protocol using NEB 10-beta Competent E. coli (C3019H) v2
Authors: England Biolabs New
Published: September 2017

This is the correct protocol if you are using the C3019H cells. If you are using the C3019I cells, please refer to this protocol.
Internal Genomic DNA Standard for Quantitative Metagenome Analysis v3
Authors: M. Satinsky Brandon , Scott M. Gifford not provided , Byron C. Crump not provided , Christa Smith not provided , Mary Ann Moran not provided , Moran Lab not provided
Published: September 2017

Satinsky, Brandon M., et al. 'Use of internal standards for quantitative metatranscriptome and metagenome analysis.' Methods in enzymology 531 (2012): 237-250.
Permutation Analysis: Eyetracking Study (Abbott-Smith et al.) v3
Authors: Abbot-Smith Kirsten , Chang Franklin , Rowland Caroline , Ferguson Heather , Pine Julian
Published: September 2017

Permutation analysis for eyetracking study Permutation Analysis: Two and three year old children use an incremental first-NP-as-agent bias to process transitive sentence
Intron Sliding and Length Variability of Genes Enriched of Phase 1 Long Introns
Authors: Поверенная И.В. , Poverennaya I.V.
Published: September 2017

Due to high mutagenesis of intron sequences, intron evolution is usually considered in terms of evolution of exon-intron structures (EIS).
The shifting of intron over short distances (rare evolutionary event called intron sliding) could lead to the change of intron phase, i.e.
the intron position relative to the open reading frame. Here we analyze the EIS from four datasets of eukaryotic orthologues in order
to find out the preferable choice of intron phase during sliding and to study the correlation between orthologous intron lengths.
To identify the orthologous introns we have constructed the alignments of EIS of orthologous genes. Several sliding events with
intron phase change were revealed from the analysis; however, our initial hypothesis that in the process of sliding introns prefer
to change its phase to 0 more frequently, was not been confirmed. Nevertheless, it is necessary to expand the analysis on a larger
dataset for making a proper conclusions. Despite high variability of intron length, some taxonomic groups share the similar length values.
Moreover, some length conservation could be observed if instead of intron length L we consider a normalized length
N = (L-A)/A, where A is an average length within an orthologous intron group.
E.g. for ptprd genes of birds (28 species) the normalized value is in the
interval (-0.15, 0.15) for 85.2 % of introns what is significantly higher than the values for random lengths set in accordance with the intron
lengths distribution. That length “conservation” leads us to the question what intron length was in the ancient introns.
The Myth of Apolitical Volunteering for Refugees: German Welcome Culture and a New Dispositif of Helping
Authors: Fleischmann Larissa , Steinhilper Elias
Published: September 2017

During the so-called “refugee crisis”, the notion of an unparalleled German hospitality toward asylum seekers circulated within the (inter)national public sphere, often encapsulated by the blurry buzzword “Welcome Culture”. In this article, we scrutinize these developments and suggest that the image of the so-called “crisis” has activated an unprecedented number of German citizens to engage in practices of “apolitical” helping. We argue that this trend has contributed to the emergence of what we term a new dispositif of helping, which embeds refugee solidarity in humanitarian parameters and often avoids an explicit political, spatial, and historical contextualization. This shift has activated individuals from the socio-political centre of society, well beyond the previously committed radical-left, antiracist, and faith-based groups. However, we aim to unmask forms of “apolitical” volunteering for refugees as a powerful myth: the new dispositif of helping comes with ambivalent and contradictory effects that range from forms of antipolitics to transformative political possibilities within the European border regime.
The Noborder Movement: Interpersonal Struggle with Political Ideals
Authors: Gauditz Leslie
Published: September 2017

Over the last decade, self-organized refugee protests in Europe have increased. One strand of activism in Europe, noborder, involves a transnational network of people who are heterogeneous with regards to legal status, race, or individual history of migration, but who share decolonial, anti-capitalist ideals that criticize the nation-state. Noborder activists embrace prefigurative strategies, which means enacting political ideals in their everyday life. This is why this article asks: How do noborder activists try to meet their political ideals in their everyday practices, and what effects do these intentions entail? Noborder practices take place at the intersection of self-organization as a reference to migrants’ legal status or identity, on the one hand, and self-organization as anti-hierarchical forms of anarchist-autonomous organization, on the other. On the basis of empirical findings of a multi-sited ethnography in Germany and Greece, this article conceptualizes that noborder creates a unique space for activists to meet in which people try to work productively through conflicts they see as being produced by a global system of inequalities. This demanding endeavor involves social pressure to self-reflect and to transform interpersonal relationships. Broader society could learn from such experiences to build more inclusive, heterogeneous communities.
Gentios, judeus e hereges: os não cristãos nos concílios de Elvira (306) e Arles (314)
Authors: De Carvalho Júnior Macário Lopes
Published: September 2017

Os concílios eclesiásticos de Elvira (306) e Arles (314) editaram um conjunto de normas que disciplinavam a conduta dos cristãos. Uma parte dessa legislação concerne às relações entre os cristãos e os não cristãos nas comunidades representadas nessas duas assembleias. Politeístas, denominados nessas normas gentios, judeus e hereges, são categorias que emergem de uma leitura a contrapelo desta documentação. As relações estabelecidas entre os que são e os que não são cristãos ajudam-nos a entender esse período de consolidação da religião cristã e a crescente capacidade de legislar sobre a vida privada dos indivíduos, uma inovação cristã.
Produção e circulação do discurso Contra Eunômio a partir dos Exilium e Relegatio de Gregório de Nissa (século IV d. C.)
Authors: Papa Helena Amália
Published: September 2017

Durante muito tempo, a historiografia analisou os documentos de Gregório de Nissa (335/340-394 d. C.) como apêndice para os escritos dos outros dois Padres Capadócios: Basílio de Cesareia e Gregório de Nazianzo. Este artigo tem o objetivo de compreender o período de produção e circulação do discurso Contra Eunômio de Gregório de Nissa a partir de eventos vivenciados pelo próprio autor. Dessa maneira, intentamos relacionar os períodos de exilium e relegatio de Gregório com a produção e circulação de seu discurso Contra Eunômio.
Demóstenes e a defesa da soberania políade
Authors: André Alessandra
Published: September 2017

No presente artigo, exploraremos o pensamento político de Demóstenes (384-322 a. C.) referente à defesa da autonomia da polis e à ação antimacedônia. Teremos como foco de análise as três Filipícas, com a intenção de captar, nesses discursos, o sentido da identidade grega ligada ao sistema políade, único sistema político visto por Demóstenes como digno para os helenos e o único capaz de preservar a liberdade da Hélade. Em contrapartida, iremos examinar como, ao mesmo tempo, Demóstenes, ao falar do ser grego, da natureza da polis, constrói toda uma retórica segundo a qual Filipe II, rei da Macedônia, é simbolizado como bárbaro e inimigo da Hélade.