bluuebunny/crossref_metadata_2025 huggingface dataset:
Разработка цифровой автоматизированной системы управления для реализации энергоэффективного освещения
Authors: Кондратьева Н.П. , Большин Р.Г. , Туктарев М.Л. , Краснолуцкая М.Г.
Published: May 2023

В статье предложена разработка цифровой автоматизированной системы управления для создания энергоэффективного освещения в метизном цехе предприятия. Для управления внутренним освещением выбран программируемый микро ПЛК (программируемый логический контроллер) типа К2000П. Разработанная система управления позволит сэкономить в течение года более чем на 60% потребление электрической энергии. Годовой экономический эффект составил 283 244 руб., а срок окупаемости 1,2 года.
Особенности проектирования жилых зданий в особых климатических условиях
Authors: Филиппова С.В. , Бережная Е.Д. , Тухватшина Э.И.
Published: May 2023

В статье анализируются особенности проектирования жилых зданий в условиях особого климата климата на примере г.Уфы. Рассматриваются климатические особенности данного города. Приводятся примеры конструкций, особенности применения материалов, которые пригодны для этой местности. Рассказывается о возможных разрушениях строительных элементов и предлагаются варианты решений основных проблем, связанных с особенностями климата.
Режим как средство обеспечения безопасности учреждений УИС и его влияние на ее эффективность
Authors: Ковалев О.Г.
Published: May 2023

В статье рассматривается один из важнейших институтов УИП – режим и его значение для обеспечения безопасности учреждений УИС. Обоснована авторская позиция понимания режима как специфического средства обеспечения пенитенциарной безопасности. Анализируются основные субъекты и условия реализации режима.
Образы животных в обрядах Востока (на примере Китая)
Authors: Шереметьева Н.В.
Published: May 2023

В статье рассматриваются образы животных в обрядах Востока (на примере Китая). Определено, что животные удовлетворяют физические потребности человека, символически отражают ценности определенного этноса, являются олицетворением сверхъестественных сил. Рассмотрены образы Тигра, Мыши, Дракона, Змеи, Черепахи, Быка, Кота, Лисицы. Сделан вывод о том, что образы домашнего скота связаны с историей, земледелием, традициями определенных этнических групп, задействованных в сельском хозяйстве; образы диких животных чаще всего символизируют внешние божественные силы, влияющие на получение урожайности, благополучия, счастья, домашнее животное Кот и дикая Лисица имеют двоякую сторону и внутреннюю направленность на душу и личность человека, от действий которого зависит, получит ли он счастье или несчастье. Отмечено, что развитие обрядности способствовало их символическому воплощению в жизни этноса: пищевые пристрастия, одежда из шкур животных, изобразительное и декоративно-прикладное искусство, архитектура.
Анализ финансово-экономической деятельности аптечной организации «ЕАПТЕКА»
Authors: Ковалева Т.Г. , Саркисян К.А.
Published: May 2023

Проведено исследование финансово-экономической деятельности аптечной организации «ЕАПТЕКА» за 2020-2021гг. Методом коэффициентного анализа изучены ликвидность, финансовая устойчивость, рентабельность и деловая активность организации. Вероятность банкротства изучена по пятифакторной модели Альтмана.
A Study of the Antihyperlipidemic and Antioxidant Activities of Ethanolic Extracts of Leaves of Houttuynia cordata Thunb . (EELHC) in Albino Rats
Authors:   Department of Pharmacology, Assam Medical College, Dibrugarh, Assam, India, Tassa Bikram Dutta , Sahu Navajit , Pathak Pradumna
Published: May 2023

The present study was designed to evaluate the antihyperlipidemic and antioxidant activities of leaves of Houttuynia cordata Thunb. The ethanolic extract was obtained by percolation method and acute oral toxicity tests were performed according to OECD (Organization for Economic Cooperation and Development) guidelines. Hyperlipidaemia was induced by feeding the rats with a high-fat diet consisting of coconut oil and vanaspati ghee, in a ratio of 2:3 v/v at a dose of 10 ml/Kg body weight. The extract was given at a dose of 500mg/kg body weight. Lipid profile, Malondialdehyde (MDA), Catalase (CAT), and Superoxide Dismutase (SOD) were measured using standard methods. The extract showed a significant decrease in total cholesterol, triglycerides, LDL, and MDA in the blood. On the other hand, HDL, CAT, and SOD increased significantly. The study demonstrates that the ethanolic extract of leaves of Houttuynia cordata Thunb., decreases blood lipid levels and lipid peroxidation. Keywords: Antihyperlipidemic, Antioxidant, Houttuynia cordata Thunb, EELHC
Fabrication of Sublingual Alprazolam Wafers using Mucoadhesive Vigna mungo L. Seeds and Characterized with Texture Analyzer QTS-25
Authors: Ali Kazi Asraf ​ , Das Riya , Choudhuri Sabyasachi
Published: May 2023

Our primary goal of this work was to create and test a mucoadhesive lyophilized rapid dissolving sublingual wafer of Alprazolam using a natural mucoadhesive agent extracted from black gram (Vigna mungo L.) seeds. We examined the pH, swelling volume, moisture absorption capability, mucoadhesive strength, and viscosity of the natural mucoadhesive agent. We compared it with synthetic mucoadhesive agents such as Hydroxypropyl cellulose (HPC) and Carbopol 934 (CP 934). The prepared wafers of both categories were characterized and compared for mechanical and texture properties, wetting time, disintegration time, Scanning Electron Microscopy (SEM), in vitro drug release, and ex vivo permeation study. We found that the pH of V. mungo mucilage (VMM) was 6.95±0.75, which lies between the normal sublingual mucosal range (pH 6-7), suggesting non-irritability to the mucosa. Attenuated total reflectance-Fourier-transform infrared (ATR-FTIR) peak showed no significant interaction between Alprazolam and mucoadhesive materials. The micrographs of SEM predicted good porosity of the wafer which leads to rapid wetting, disintegration, and dissolution. It is inferred from the study that the fast-dissolving wafer prepared from the VMM gave a better result than the HPC wafer in respect of various parameters. Hence, this study discovered an alternative method to deliver Alprazolam. Keywords: Lyophilization, Permeability, Solid dosage form(s), Mucoadhesive, Texture
ACİL SERVİSTE İDRAR YOLU ENFEKSİYONU İÇİN BAŞLANAN AMPİRİK ANTİBİYOTİK İLE KÜLTÜR ANTİBİYOGRAM DUYARLILIĞININ KARŞILAŞTIRILMASI
Authors: ÇAKIR Adem , ACAR Hüseyin
Published: May 2023

Giriş ve Amaç: Üriner sistem enfeksiyonları (ÜSE) hem ayaktan hem de yatarak tedavi edilen en yaygın enfeksiyonlardan biridir. Tedavide antibiyotik kullanımı ve antibiyotiklere olan direnç git gide artmıştır. Çalışmamızda, acil serviste ayaktan tedavi edilen ÜSE olgularına reçete edilen antibiyotik ile kültür antibiyogramındaki direnç/duyarlılık düzeylerini karşılaştırmayı ve literature katkı sağlamayı amaçladık.

Materyal ve Metot: Çalışmamız retrospektif ve tek merkezli bir çalışmadır. Çalışma dahil edilme kriterlerini karşılayan 1503 hasta ile yapıldı. Olguların demografik verileri, laboratuvar verileri ve klinik verileri daha önceden oluşturulmuş çalışma formuna kaydedildi. İstatistiksel anlamlılık düzeyi için p
Preface to the CLTM-CLTD 2022 Special Issue
Authors: Cancela Héctor
Published: May 2023

This preface opens the special issue on invited papers related to the 2023 edition of the MSc. and PhD. thesis contests organized by CLEI, the Latin American Center for Computing Studies.
One of the main objectives of CLEI is furthering the scientific development of all Computing areas in Latin America. To recognize such developments, as well as the achievements of the graduate programs in the region, and promote the development of new programs, CLEI organizes yearly since 1993 the LatinAmerican Master Thesis Contest (CLTM), and since 2016 the Doctoral Thesis Contest (CLTD). Both events take place jointly with the Latin American Computing Conference (also known as CLEI conference) .
In the 2022 edition, the conference took place in Armenia, Quindio, Colombia; both the MSc. and PhD. contests received a number of high quality submissions, leading to very interesting presentations during the conference and to excellent prizes.
After the conference, the authors of the best works (receiving prizes as well as runner-ups) were invited to submit original works, not already published, to the CLEIej journal. These submissions were evaluated by independent reviewers, following the usual review process of the journal. As a result of this selection process, we are proud to present the current Special Issue.
Correlation of White Matter Lesions Severity and Age in Ischemic Stroke at Siloam Jember Hospital
Authors: Heni Fatmawati  , Celly Afifah Pramono  , Muhammad Afiful Jauhani  , Azham Purwandhono  , Ali Santosa
Published: May 2023

White matter lesions is a disease that is often found in stroke patients and is associated with an increased risk of stroke. In addition, WML is often referred to as a degenerative disease. Stroke is one of the diseases with a high prevalence in Indonesia, including in East Java. Stroke is also often associated with increased age. The most common cause of stroke is due to ischemia in the brain. The research conducted was observational analytical research with a cross-sectional research design. The data used in the study was a medical record of magnetic resonance imaging (MRI) examination. WML severity degrees are differentiated using the Fazekas scale. The study was conducted on 60 samples. The results showed a significant and positive relationship with a p-value of 0.016 and a correlation coefficient of 0.31. From the results of the study, it can be concluded that there is a relationship between the severity of WML and increased age in chronic stroke patients at Siloam Hospital Jember with the strength of the relationship between the two variables is weak.

 

Keywords             : White Matter Lesions, Ischemic Stroke, Age, MRI, Fazekas

Correspondence        :           fatmawatiheni@unej.ac.id
Hubungan Antara Faktor Risiko dengan Kejadian Preeklampsia di Puskesmas Kencong Jember
Authors: Pattipeilohy Florence , Parti Dita Diana , Firdaus Jauhar , Sakinah Elly Nurus , Cahyana Nugraha Wahyu , Fatmawati Heni
Published: May 2023

Jumlah kematian ibu tertinggi di Provinsi Jawa Timur pada tahun 2020-2021 berada di Kabupaten Jember. Salah satu penyebab kematian ibu adalah preeklampsia. Preeklampsia dapat dipengaruhi oleh faktor risiko seperti usia, tingkat pendidikan ibu, pekerjaan, status gravida, paritas, obesitas, dan jarak kehamilan. Penelitian ini bertujuan mengetahui hubungan antara faktor risiko dengan kejadian preeklampsia di Puskesmas Kencong Kabupaten Jember. Metode penelitian yang digunakan adalah analitik observasional dengan desain penelitian case control. Sampel diambil menggunakan metode purposive sampling dengan total sampe sebanyak 51 ibu hamil. Data penelitian merupakan data sekunder yang berasal dari rekam medis, buku register Kohort, dan buku KIA ibu hamil di Puskesmas Kencong tahun 2020-2021. Data yang didapatkan dianalisa dengan uji Chi Square. Hasil penelitian ini membuktikan tingkat pendidikan dan obesitas memiliki hubungan dengan kejadian Preeklampsia di Puskesmas Kencong.
Salles Dounner: art-nula – desenhos, um livro para além das imagens
Authors:   Universidade Estadual Paulista, Freitas Daive Cristiano Lopes de
Published: May 2023

Neste trabalho pesquisamos sobre os primeiros anos de vida do artista plástico e poeta francano Salles Dounner até a idade adulta e suas experiências relatadas pelo próprio artista e por familiares e amigos. Este funde um breve histórico do desenvolvimento econômico e social de Franca com o desenvolvimento da cultura artística local disseminada pelos estilos acadêmico e moderno. Neste captamos os anos de vivência de Salles enquadrando-o desde fim do período populista, o regime militar até a nova democracia no Brasil. Também conheceremos o ciclo artístico de Salles Dounner em Franca em suas fases dos anos setenta, oitenta e início dos noventa como o artista marginalizado que se apresentava.
A pintura de marinha no Brasil: um ensaio curatorial
Authors:   Universidade Estadual de Campinas, Oliveira Helder
Published: May 2023

O objetivo desta comunicação é apresentar alguns questionamentos para a execução de uma curadoria sobre a pintura de marinha no Brasil, entre o final do século XVIII e o início do século XX, que foram levantados durante a realização de minha pesquisa de doutorado sobre o tema. Ao tomarmos a exposição como um discurso visual, isto é um evento cujas ideias são apresentadas por meio dos objetos expostos, a seleção e sua organização no espaço, devem ser feitos de maneira a facilitar a compreensão das ideias expostas.
A arte a serviço do sagrado: a arte sacra de Cláudio Pastro (1948-) e o santuário nacional de nossa senhora da conceição aparecida
Authors:   Universidade Estadual de Campinas, Berto João Paulo
Published: May 2023

No campo contemporâneo das artes plásticas ditas sacras, percebe-se certa uniformização de traços, cores e imagens. Esta nova concepção do pensar artístico, contudo, é reflexo de uma série de discussões que foram travadas no seio da Igreja Católica desde o final do século XIX, aliando arte, teologia e liturgia. Esta apresentação, assim, busca tratar sobre estes discursos da arte sacra, tomando a obra do brasileiro Cláudio Pastro (1948-) como estudo exemplar nestes apontamentos.
A diluição do plano bidimensional no espaço: análises e relações entre quatro obras seminais de integração arquitetônica de Athos Bulcão
Authors:   Universidade de São Paulo, Alves Leandro Leão
Published: May 2023

A integração entre a arte e a arquitetura foi a principal tônica nos trabalhos de Athos Bulcão, artista que tem como um dos principais legados o conjunto de obras realizados sob o lastro da síntese das artes no período moderno brasileiro, como murais e painéis, principalmente seu conjunto de obras na cidade de Brasília
Atrações perversas: apontamentos sobre Macabro (1980) de Lamberto Bava
Authors:   Universidade Estadual de Campinas, Campos Letícia Badan Palhares Knauer de
Published: May 2023

Este texto parte da análise do filme Macabro (1980), de Lamberto Bava, procurando entendê-lo dentro da produção do cinema de horror, sobretudo dos anos de 1980 e sua relação com o universo da História da Arte, como o simbolismo e o decadentismo, nos quais o apreço pelo grotesco em correspondência com o prazer aparecem com evidência.
A instalação e a exposição: relações entre o espaço-tempo de exposição e a curadoria
Authors:   Universidade Federal de Viçosa, Silva Luciana Bosco e
Published: May 2023

A Instalação, assim como seus antecessores os ambientes e Environments não tiveram um acesso simples e tranquilo aos espaços consagrados dos museus. Em seu caminho de arte marginal à arte institucionalizada houve alguns tropeços. No entanto a entrada da Instalação nos prestigiados espaços museológicos se deu no fim dos anos 1960, em resultado da pressão da comunidade artística que se formava à época.
Frederico Morais e a crise da vanguarda no Brasil (1960-70)
Authors:   Universidade Federal de Goiás, Mari Marcelo
Published: May 2023

A crise institucional imposta pelo golpe militar de 1964 pôs fim derradeiro às vanguardas construtivas e ao estabelecimento de um novo estágio de influências e de alternativas possíveis da arte brasileira, processado como manifestação consequente de uma crise ética, política e social que assolou o País. Se a tendência construtiva da arte brasileira fez parte do período desenvolvimentista dos anos de 1950 e dramatizou sua crise, a partir da década seguinte com o Golpe Militar e os anos que o sucederam, as sendas artísticas brasileiras estiveram ligadas ao movimento generalizado internacionalmente de nova figuração, de pop arte ou de antiartes e tiveram entre suas manifestações epígonas a arte conceitual que acompanhou todo processo de recrudescimento da repressão política nos anos finais de 1960 e durante a década seguinte de 1970.
Retratos de um relacionamento: Nan Goldin e a fotografia da vida íntima
Authors:   Universidade Estadual de Campinas, Souza Ronaldo Ferreira de
Published: May 2023

Nan Goldin se notabilizou por suas fotos íntimas, em que expõe sua vida, tornando público o que antes era privado, com The Ballad of Sexual Dependency ela leva isso até as últimas consequências. O presente texto se debruçará sobre um fragmento da referida obra, fragmento este que retrata o relacionamento conflituoso da artista com Brian Burchill, que foi um de seus grandes amores.
Anita Malfatti na independent school of art
Authors:   Universidade Estadual de Campinas, Romão Tameny
Published: May 2023

Em 1951, a artista considerada precursora do movimento modernista no Brasil, Anita Malfatti, produziu uma conferência a ser apresentada na Pinacoteca do Estado de São Paulo, na qual relatou dados biográficos referentes à sua formação. No texto, a pintora revela a dedicação à Arte nos anos iniciais da carreira, estudos que culminaram na exposição realizada por ela entre os anos
Proposta de um Índice de Miséria Ampliado para o Brasil e sua evolução no período 2012-2021
Authors: Saboia João , Hallak Neto João
Published: May 2023

Este artigo recupera o índice de miséria criado por Arthur Okun incorporando novas variáveis disponíveis no país. É desenvolvida uma metodologia para o novo índice, que amplia seu escopo original e passa a considerar, além da inflação, a subutilização da força de trabalho e as dimensões de renda domiciliar e endividamento familiar excessivo. Os resultados encontrados com o índice para o período 2012-2021 mostram grande flutuação, que se inicia com queda até 2014, seguida por crescimento até 2016 e tendência de alta moderada em 2017-2019. O índice volta a crescer em 2020, atingindo o valor mais elevado do período em 2021 e apontando para o aumento das dificuldades enfrentadas pela população no final do período analisado.
Propiedades psicométricas e invarianza del Cuestionario Habilidades Comunicativas (HABICOM) en universitarios peruanos
Authors: Puma-Maque Oscar C. , Asillo Yenny Y. , Mendoza Amparo P. , Adriazola Sulema J.
Published: May 2023

The aim of the present study was to evaluate the psychometric properties and gender invariance of the Communication Skills Questionnaire (HABICOM). The sample consisted of 774 students from a state university in Arequipa. The factors were analyzed and confirmed as in the original study, obtaining satisfactory fit indices in its two subscales Personal Self-perception (c2 = 1977.683, gl = 499, p < .001; CFI = .945; TLI: .939; RMSEA = .061; SRMR = .042) and Professional Importance (c2 = 2534. 513, gl = 517, p < .001; CFI = .926; TLI = .919; RMSEA = .070; SRMR = .049) with adequate reliability indices on both subscales, for Personal Self-Perception (α = .63 and α = .85) and Professional Importance (α = .91 and α = .77) respectively. Gender invariance was adequate for the Personal Self-perception subscale; however, this did not occur for the Professional Importance subscale. The HABICOM questionnaire in general is adequate to measure communication skills in Peruvian university students. The aim of the present study was to evaluate the psychometric properties and gender invariance of the Communication Skills Questionnaire (HABICOM). The sample consisted of 774 students from a state university in Arequipa. The factors were analyzed and confirmed as in the original study, obtaining satisfactory fit indices in its two subscales Personal Self-perception (c2 = 1977.683, gl = 499, p < .001; CFI = .945; TLI: .939; RMSEA = .061; SRMR = .042) and Professional Importance (c2 = 2534. 513, gl = 517, p < .001; CFI = .926; TLI = .919; RMSEA = .070; SRMR = .049) with adequate reliability indices on both subscales, for Personal Self-Perception (α = .63 and α = .85) and Professional Importance (α = .91 and α = .77) respectively. Gender invariance was adequate for the Personal Self-perception subscale; however, this did not occur for the Professional Importance subscale. The HABICOM questionnaire in general is adequate to measure communication skills in Peruvian university students.
Dynamics of estrogenic activity in an urban river receiving wastewater effluents: effect-based measurements with CALUX
Authors: Elskens Marc , Van Langenhove Kersten , Carbonnel Vincent , Brion Natacha , Eisenreich Steven J.
Published: May 2023

Estrogenic substances (ES) in an urban river Zenne (BE) dominated by wastewater effluents were assessed over the course of one year. To measure the bioequivalent (BEQ) 17 β-estradiol (E2) concentrations of ES, the biological effect-based methodology - the Chemical-Activated LUciferase gene eXpression (CALUX) bioassay was used. Daily water discharges were collected from January 2015 to February 2016 at or near the sampling stations in the Brussels Capital Region. An annual water budget shows that approximately 50% of the Zenne River flow downstream is from wastewater effluent. The estrogenic activity and yearly average ES load in influents and effluents of wastewater treatment plants (WWTPs) located in the North and South, combined sewer overflows (CSOs) and the Zenne River, were assessed for upstream and downstream of two WWTPs of Brussels. Both WWTPs with activated sludge treatment remove more than 90% of the ES. The influent concentrations of ES at the South and North WWTPs ranged from 30-359 and 18-55 ng E2 eq./L, respectively. The effluent concentrations of ES ranged from 1.0-2.1 and 1.1-6.6 ng E2 eq./L at WWTP-S and -N, respectively. The yearly average ES loads were 0.05-0.14 and 0.39-1.5 g E2 eq./d for WWTP-S and -N, respectively. The temporal variation of E2-eq concentrations at the river stations Z3 and Z5 (upstream) ranged from 1 to 2 ng E2 eq./L, while the ES activity at sites Z9 and Z11 (downstream) varied from 2-17 ng E2 eq./L and from 1-8 ng/L ng E2 eq./L, respectively. The relative ES loads to the Zenne River are as follows: WWTPs (31%), CSOs (27%), upstream Zenne (15%), a missing source (14%), and local tributaries (13%). ES in the Zenne River behave in a pseudo-persistent manner because of continuous input from the WWTPs and slow degradation in the 18 km river stretch. The BEQ concentration of E2 exceeds the EU environmental quality standards (EQS) of 0.4 ng E2/L throughout the Zenne River.
Molecular-assisted analysis of indigenous chicken semen to increase rooster fertility in tropics
Authors: Hamidu Jacob Alhassan , Tsekumah Richard , Iddrisu Amina , Gariba Stepehn , Opoku Mitchell Agyei , Kafari Emmanuel , Appenteng Kofi , Kyere Patrick Nana
Published: May 2023

Male fertility impacts greatly on hatchability and chick quality. The study assessed semen and sperm quality characteristics of indigenous chicken breeds. Ten brown normal feathered (NF) birds and 10 brown naked neck (NN) birds selected over six generations were investigated for semen volume, concentration, viscosity, sperm viability, morphology, motility, and sperm DNA fragmentation to predict fertility. The results showed that the mean semen volume of NF males (0.399 ml) was higher compared to NN males (0.237 ml.) The sperm viability count through a trypan blue exclusion test in NF was lower (62.7%) compared to NN (67.0%). However, the sperm concentration in NN cocks (4.3 × 106 sperms/ml) was higher compared to NF birds (3.0 × 106 sperms/ml) (p < 0.05). The morphology of sperms indicated that the percentage of normal sperms in NF versus NN was 69% and 71%, while the percentage of abnormal sperms was 31% as against 29%. Although NN had a high normal-to-abnormal sperm ratio, a high amount of normal sperm was recorded in NF as compared to the NN. However, the sperm motility pattern indicated that the movement of sperm in NN males was better than NF birds. DNA fragments from NF chicken sperms were lighter in weight and ran faster through the gel matrix, indicating higher amount of DNA fragmentation than the NN chickens. The semen and sperm analysis indicates fertility differences resulting from males between the two breeds in hot temperature conditions with the NN showing higher potential for higher fertility than NF birds.
Impact of the Grain for Green Project on the well-being of farm households: A case study of the mountainous areas of northern Hebei Province, China
Authors: Wang Kun , Sun Piling , Wang Xin , Mo Junxiong , Li Nan , Zhang Jinye
Published: May 2023

There are close dynamic relationships among the livelihood, well-being, and ecological environment of farm households. It is of great significance to scientifically clarify the impact of the grain for green policy on the livelihoods and well-being of farm households in mountainous areas. Based on data from a survey of 392 farm households in Zhangbei County, a system of indicators for farm household livelihood assets and farm household well-being was constructed, drawing on a sustainable livelihood framework (SLF). The livelihood assets and well-being levels of different types of farm households were measured, and a multiple linear regression model was used to analyze the impact of the grain for green policy implementation on the well-being levels of farm households. The three main results are as follows: (1) The level of natural assets among the total average livelihood assets of farm households in Zhangbei County is the highest at 0.374, while the level of physical assets is the lowest at 0.018. The level of livelihood assets of returned farmland households (0.948) is lower than that of nonreturned farmland households (1.117). (2) The level of well-being of all farm households in Zhangbei County is 0.517, with the level of wealth contributing the most to the well-being of farm households at 40.20% and the quality of the ecological environment contributing the least at 11.99%. The level of well-being of returned farmland households (0.518) was slightly higher than that of nonreturned farmland households (0.514). (3) The degree of influence of each influence factor on the level of well-being of farm households varies significantly. Household size was the strongest driver, at 0.366, while educational attainment of household members, household labor capacity, annual household expenditure, livelihood diversity, number of large production tools, and total value of livestock were also important drivers of household well-being, and area of arable land is negatively associated with household well-being. There are also differences in the factors influencing the level of well-being of different types of farming households.
Uncovertebral Joint Fusion Versus End Plate Space Fusion in Anterior Cervical Spine Surgery
Authors: Sheng Xia-Qing , Yang Yi , Ding Chen , Wang Bei-Yu , Hong Ying , Meng Yang , Liu Hao
Published: May 2023

Background:

The uncovertebral joint is a potential region for anterior cervical fusion. Currently, we are aware of no clinical trials on human uncovertebral joint fusion (UJF). The purpose of this study was to compare the time it took to achieve osseous union/fusion and the clinical efficacy of UJF to end plate space fusion (ESF)—i.e., traditional anterior cervical discectomy and fusion (ACDF)—in anterior cervical surgery.

Methods:

Patients with single-level cervical spondylosis were recruited from April 2021 through October 2022 and randomly divided into the UJF and ESF groups, with 40 patients in each group. Autologous iliac bone was used for bone grafting in both groups. The primary outcome was the early fusion rate at 3 months postoperatively. Secondary outcomes included the prevalence of complications and patient-reported outcome measures (PROMs), including the Japanese Orthopaedic Association (JOA) score, Neck Disability Index (NDI), and visual analog scale (VAS) scores for arm and neck pain.

Results:

A total of 74 patients (92.5%) with an average age of 49.8 years (range, 26 to 65 years) completed the trial and were included in the analysis. There was no significant difference between the 2 groups at baseline. The operative duration and intraoperative blood loss were also comparable between the 2 groups. The fusion rate in the UJF group was significantly higher than that in the ESF group at 3 months (66.7% compared with 13.2%, p < 0.0001) and 6 months (94.1% compared with 66.7%, p = 0.006) after the operation. No significant difference was found in the fusion rate between the 2 groups 12 months postoperatively. Overall, the PROMs significantly improved after surgery in both groups and did not differ significantly between the groups at any follow-up time point. The prevalence of complications was not significantly different between the 2 groups.

Conclusions:

In our study of anterior cervical fusion surgery, we found that the early fusion rate after UJF was significantly higher than that after ESF.

Level of Evidence:

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
PENGEMBANGAN PEMASARAN UMKM BATIK TULIS UNTUK MENINGKATKAN PEREKONOMIAN MASYARAKAT DI DESA GENILANGIT KECAMATAN PONCOL KABUPATEN MAGETAN
Authors: Nofitasari  , Amri Muhtadin
Published: May 2023

During the current pandemic, many people are unemployed, lack education, and lack knowledge about skills, so the purpose of this activity is training for the development of written batik marketing in Genilangit village. The actions we carry out can be helpful and also able to increase and foster enthusiasm for entrepreneurship for PKK mothers, especially young people, so that they are more enthusiastic about innovating and creating so that local people can live prosperously from their work. In addition to guiding the importance of innovation and entrepreneurship, we also conduct training on the digital world and ways to promote UMKM products to be well-known in the broader community. Within the Genilangit Village community, the marketing strategy still needs to be higher, so hand-written batik needs to be famous outside Genillangit Village. This service aims to help promote the market of Genilangit-written batik so that it is known in the wider community. Because in this day and age, social media is increasingly sophisticated, so it's easier to promote goods. As a good seller, you must sell in the right way so that consumers are satisfied with the products you sell, don't because selling online we ch by selling goods that don't match consumer orders because customers are the most important in buying and selling transactions.
Optimalisasi Potensi Wakaf Tunai sebagai Penggerak Bisnis Melalui Pengembangan Fintech Wakaf di Era Digitalisasi
Authors: Risma Khoirun Nazah
Published: May 2023

Nowadays technological development is progressing very rapidly. Almost every line of life has been digitalized, this can be seen by the emergence of many technology-based applications that facilitate human activities. The rise of this trend also impacts waqf, especially cash waqf. If in the past waqf was only based on land for the construction of mosques, burial ground, or educational institutions but now waqf can also be in the form of cash. One of the digitalization systems that is being developed in the field of waqf is the waqf financial technology system. The existence of this system can facilitate prospective waqf in having a waqf and can increase the interest of the community which incidentally does not intend to endowments to be interested in parenting. In addition, funds from cash waqf can drive the economy by bringing up a start-up business for those mauquf alaih.

Dewasa ini, perkembangan teknologi mengalami kemajuan yang sangat pesat. Hampir di setiap lini kehidupan telah terdigitalisasi, hal tersebut dapat terlihat dengan banyaknya bermunculan aplikasi berbasis teknologi yang mempermudah aktivitas manusia. Maraknya trend tersebut juga berimbas pada wakaf, tak terkecuali wakaf tunai. Apabila dahulu wakaf hanya berbasis tanah untuk pembangunan masjid, tanah pemakaman, atau lembaga pendidikan, namun sekarang wakaf juga dapat berbentuk tunai. Salah satu sistem digitalisasi yang tengah dikembangkan pada bidang perwakafan adalah sistem Financial Technology (FinTech) wakaf.  Dengan adanya sistem tersebut dapat mempermudah calon wakif dalam berwakaf serta dapat meningkatkan minat masyarakat yang semula tidak berniat untuk wakaf menjadi tertarik untuk berwakaf. Selain itu, dana hasil wakaf tunai dapat menggerakkan perekonomian dengan memunculkan suatu bisnis start-up bagi mauquf alaih.
Analisis Faktor yang Mempengaruhi Intensi Masyarakat Membayar Infak dan Sedekah melalui E-Wallet
Authors: Atmaja Anton , Amri Muhtadin
Published: May 2023

Few people know that infaq and alms payments can be made through e-wallets. So, this study aims to examine and analyze the factors influencing people's intentions to pay infaq and alms through e-wallets. This research is expected to be a reference for the community regarding infaq and alms payments through e-wallets. It can assist infaq and alms managers in finding good strategies for increasing infaq and alms collection through e-wallets. This study uses quantitative methods, data collection techniques using questionnaires via Google form, and snowball sampling techniques. This study also uses SEM-PLS data analysis techniques with the help of Smart PLS 3.3.3 software. The results of this study are that there is a positive and significant influence from personal, psychological, cultural, and social factors on people's intentions to pay infaq and alms through e-wallets. Thus, it can be concluded that personal, psychological, cultural, and social factors can determine people's intentions to pay infaq and alms through e-wallets.

Saat ini masyarakat belum banyak yang mengetahui bahwa pembayaran infak dan sedekah bisa melalui e-wallet. Maka penelitian ini bertujuan untuk menguji dan menganalisis faktor-faktor yang mempengaruhi intensi masyarakat dalam pembayaran infak dan sedekah melalui e-wallet. Penelitian ini diharapkan dapat menjadi rujukan untuk masyarakat terkait pembayaran infak dan sedekah melalui e-wallet, dan dapat membantu pengelola infak dan sedekah untuk menemukan strategi yang baik dalam meningkatkan penghimpunan infak dan sedekah melalui e-wallet. Penelitian ini menggunakan metode kuantitatif, teknik pengumpulan data menggunakan kuisioner melalui google form, serta teknik pengambilan sampel menggunakan snowball sampling. Penelitian ini juga menggunakan teknik analisis data SEM-PLS dengan bantuan software Smart PLS 3.3.3. Hasil dari penelitian ini ialah terdapat pengaruh positif dan signifikan dari faktor pribadi, psikologi, kebudayaan, dan sosial terhadap intensi masyarakat dalam pembayaran infak dan sedekah melalui e-wallet. Dengan demikian dapat ditarik kesimpulan bahwa faktor pribadi, psikologi, kebudayaan, dan sosial dapat menentukan intensi masyarakat untuk membayar infak dan sedekah melalui e-wallet.
High-Temperature-Resistant Thermal Shape Memory Polymers as Lost Circulation Materials for Fracture Formations
Authors: Zhao Zhen , Sun Jinsheng , Liu Fan , Bai Yingrui , Wang Ren , Geng Yuan , Li Yongjian , Liu Ce
Published: May 2023

Lost circulation during the drilling of fractured formations is one of the most challenging engineering problems. Shape memory polymers (SMPs) have been used as lost circulation materials, but most of them are not resistant to high temperatures. In this study, a high-temperature-resistant thermal shape memory epoxy resin (SME) was synthesized by conducting an orthogonal experiment using the glass transition temperature (Tg) as an index. The Tg of the SME synthesized by using the optimum formula was 124℃. This SME had good thermal stability, and its compression and tension stresses were 94.2 and 58.8 MPa, respectively. In addition, the thickness swelling ratio (Rrc) of the SME was optimized by performing another orthogonal experiment, and the Rrc of the SME prepared by using the optimized formulation (OSME) was 78.8%. The OSME did not swell at 25–150℃ in water, brine, or base fluid. The total size reduction percentage of the OSME was 1.7% after aging at 150℃, whereas that of a nutshell was 10.7%, indicating that OSME particles had better compression and temperature-resistance performance. The shape memory ratio (Rc) of the OSME was 6, 70, and 100% at 80, 120, and 125℃ after being heated for 50 minutes, respectively, and it was fully activated in 5 minutes at 150℃. The breakthrough pressure of the plugging mud with or without the OSME was 15 MPa at 25, 80, 120, and 150℃ when plugging the wedge fracture model with an inlet/outlet width of 3/1 mm. However, when plugging the wedge fracture model with an inlet/outlet width of 5/2 mm, the plugging slurry with the OSME could withstand a pressure of 3, 5, and 15 MPa at 80, 120, and 150℃, respectively, and the plugging mud with conventional lost circulation materials could bear a pressure of below 3 MPa at 80, 120, and 150℃. These results indicated that the OSME had good plugging and thermosensitive performance. OSME particles matched better with the fracture size, owing to their elastic and shape memory performance at above Tg. They migrated and bridged in fractures, aggregated and filled the pore space with other lost circulation materials, and formed a dense plugging layer at above Tg. Thus, the synthesized SME is a promising material for plugging high-temperature fracture formations while drilling.
Chicken nuclear DNA in chicken egg whites
Authors: Zyrianova Irina M.
Published: May 2023

Poultry eggs contain high-quality proteins, fat, vitamins, and minerals necessary for human nutrition as food and ingredients in the food industry. Egg whites have exceptional foaming, emulsifying, gelling, and heat setting properties, making them popular for use in baked goods. Intensive study of egg whites to date has now settled on a stable opinion that there are no cells, and no DNA, in them. However, this study demonstrates the possibility of chicken nuclear DNA extraction from outer thin whites of chicken eggs.
Linkages between Energy Prices and Energy Stocks in China: A Study Based on Wavelet Analysis
Authors: Zhao Tianyu , He Yongda , Bai Martin , Shao Shuai
Published: May 2023

This study constructs a comprehensive energy price index and applies the Morlet continuous wavelet transform to investigate the relationship between energy prices and energy industry stock markets. It also tests the multi-scale linear and nonlinear causality using multi-resolution decomposition. The empirical findings indicate that: (1) energy prices and stock market volatilities demonstrate a stable negative correlation in the medium- and long-term frequency domain, and the fluctuation of energy stock prices precedes that of energy prices since 2018. (2) Energy prices and stock markets exhibit bidirectional causality. The short- and medium-term driving effects of energy stocks and energy prices are more pronounced than the overall change in stock markets over a period of 16 months. The linkage between energy prices and stock markets is primarily influenced by the stock market leading and driving energy price changes, indicating a common long-term trend. (3) In the long run, fluctuations in Chinese stock markets will lead to a reverse change in energy prices, providing policy management in the energy industry with an effective reference. However, the unstable short-term characteristics and lag of energy price changes suggest that the impact of energy prices on stock market investment has less reference value.
Super-promoters: Cooperativity between juxtaposed promoters
Authors: Wiechens Elina , Vigliotti Flavia , Riege Konstantin , Bömmel Alena van , Schwab Katjana , Görlich Ivonne , Bens Martin , Schwarz Robert , Sahm Arne , Groth Marco , Loewer Alexander , Hoffmann Steve , Fischer Martin
Published: May 2023

The coordination of transcription through enhancers and promoters is a fundamental process that has a central role in development and disease 1–3. Convergent transcription, i.e., the collision of sense and antisense transcription, is ubiquitous in mammalian genomes 4–8 and believed to diminish RNA expression 9,10. Recently, antisense transcription downstream of promoters was found to be surprisingly prevalent 11–13. However, functional characteristics of promoters with convergent transcription are unknown. Here, we show that convergent transcription marks an unexpectedly cooperative promoter constellation we call super-promoters. By assessing transcriptional dynamic systems, we identified strongly cooperative constituent promoters that are connected through a distinct chromatin structure. Within these super-promoter constellations transcription factors can regulate both constituting promoters by binding to only one of them. Super-promoters comprise about a fourth of all active transcript starts and initiate 5’-overlapping antisense RNAs, an RNA class previously believed to be rare 4. Visualization of nascent RNA molecules provides evidence for convergent co-transcription at these loci. Our results demonstrate that super-promoters substantially expand the cis-regulatory repertoire and reveal limitations of the standing model of transcription interference. Together, our study revises the promoter architecture of many genes and calls for adjusting the promoter concept.
Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets
Authors: Wiemann Stefan , Beumers Lukas , Vlachavas Efstathios , Borgoni Simone , Schwarzmüller Luisa , Penso-Dolfin Luca , Michels Birgitta , Sofyali Emre , Burmester Sara , Heiss Daniela , Wilhelm Heike , Yarden Yosef , Helm Dominic , Will Rainer , Goncalves Angela
Published: May 2023

Intratumoral heterogeneity drastically impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal breast cancer and rendered them resistant to commonly applied first line endocrine therapies. By deconvoluting complex resistant cell pools and characterizing replicates of individual clones we observed inter- (between cell lines) and intra-tumor (between different clones from the same cell line) heterogeneity. Molecular characterization at RNA and phospho-proteomic levels revealed private clonal activation of the unfolded protein response and respective sensitivity to inhibition of the proteasome, and shared sensitivities for repression of protein kinase C. Our in vitro findings mirror the tumor-heterogeneity that is observed in breast cancer patients thus highlighting the urgent need to uncover heterogeneity at an individual patient level and to adjust therapies accordingly.
Food niche overlap between two stingless bee species along a spatio-temporal gradient: implications for keeping and conservation
Authors: López-Roblero Estefhanía , Guzmán-Díaz Miguel Ángel , Sánchez Daniel , Grajales-Conesa Julieta
Published: May 2023

It is common practice that local stingless beekeepers in Southern Mexico keep their colonies, from two or more species, in a single place, referred to as meliponary. Little is known, however, if such scheme promotes competition for local resources among managed species. This is particularly relevant since in some cases over several dozens of hives are reared in one meliponary. In this study we examined the plant species visited by two culturally and economically important stingless bee species commonly kept together, Scaptotrigona mexicana and Tetragonisca angustula, in order to know the magnitude of the competition between them. Honey samples from managed colonies located in three meliponaries were collected during a year. Using standard melissopalynological techniques we analyzed them and could identify the plant species the colonies collected food from. Overall 84 pollen types were identified: 34 at the species level, 32 at the genus level and 18 at the family level. Samples of both bee species had high indexes of plant diversity; Compositae, Leguminosae and Euphorbiaceae were the most visited plant families. Niche overlap analysis showed that up to 21% of plant species were common to both bee species, but only in some months of the year. The results of this study show low competition between S. mexicana and T. angustula. With these results we provide Mexican stingless beekeepers with valuable information that supports the continuation of ancient bee management practices.
Deciphering the relationship between meteorological and hydrological drought in Ben Tre province, Vietnam
Authors: Huynh Minh , Kumar Pankaj , Toan Nguyen Van , Nguyen Phan Chi , Ty Tran Van , Lavane Kim , Tam Nguyen Thanh , Downes Nigel K.
Published: May 2023

The low-lying Vietnamese Mekong Delta (VMD) is a key agricultural production landscape increasingly threatened by anthropogenic stresses and climate change. Droughts due to extreme events, climate change and upstream developments affect the delta. This paper explores the relationship between the intensity, duration, and frequency of meteorological droughts and hydrological droughts using a range of indices. We used monthly rainfall and stream flow data for the period 1992–2021 to calculate the stream flow Drought Index (SDI), the Standardized Precipitation Index (SPI), and the Reconnaissance Drought Index (RDI) for different time intervals. We found no observed time lag, and a strong correlation coefficient between upstream hydrological and downstream meteorological drought events assessed over long-term scales (i.e.,12-months). This is true for all downstream sites, except Ben Tre City. Meteorological drought events onset lagged 5–6 months, 6-month, and 4-month behind hydrological droughts at mid- and shorter assessment time scales (9-,6-, 3- month). Average correlation coefficient between hydrological indices and SPI and 9–3 month time scales ranged only from moderate to weak. These findings shed light and advance the understanding of the progression of meteorological to hydrological droughts in the VMD. Our results aid the regional understanding of drought onset and the causative mechanism at work, important for both medium and long-term drought forecasting and adaptation planning.
Membrane-induced 2D phase separation of focal adhesion proteins
Authors: Litschel Thomas , Kelley Charlotte , Cheng Xiaohang , Babl Leon , Mizuno Naoko , Case Lindsay , Schwille Petra
Published: May 2023

Focal adhesions form liquid-like assemblies around activated integrin receptors at the plasma membrane. Made up of hundreds of proteins, focal adhesions are dynamic structures which can assemble and disassemble quickly, withstand strong actomyosin-applied forces, and form highly stable complexes. How they achieve these flexible characteristics is not well understood. Here, we use recombinant focal adhesion proteins to reconstitute the core structural machinery in vitro, with the goal of understanding the underlying protein dynamics and interactions. We observe liquid-liquid phase separation of the core focal adhesion proteins talin and vinculin for a spectrum of conditions and in combination with several interaction partners. Intriguingly, we show that binding to PI(4,5)P2-containing membranes triggers phase separation of these proteins on the membrane, which in turn induces the enrichment of integrin in the clusters. We also introduce a novel experimental setup to probe talin-membrane interactions down to the single protein level using optical tweezers. Our results suggest that membrane composition triggers condensate assembly at the membrane, a regulatory mechanism which could widely apply to membrane-localized biomolecular condensates and provide a pathway of how spatial organization of lipids within the membrane can couple into the cytosol.