bluuebunny/crossref_metadata_2025 huggingface dataset:
Kontribusi Sektor Pertanian berdasarkan Keunggulan Wilayah di Kabupaten Bangka
Authors: Tirani Tirani , Pranoto Yudi Sapta , Moelyo Haryono
Published: April 2018

This study aims to describe the contribution of agriculture sector based on superior sub-sector (base) in Bangka Regency. This research was conducted in November 2016 until May 2017 in Bangka Regency. This research uses survey method. The research uses secondary data which collected from several agencies in Bangka District. The method of analysis is Location Quotient (LQ). The result of research shows that Bakam District has one base sub-sector that is annual estate sub-sector; Belinyu District has two basic sub-sectors, namely livestock sub-sector and fishery sub-sector; Merawang District has three sub sectors namely horticultural crops sub-sector, fishery sub-sector, and livestock sub-sector; West Mendo District has two basic sub-sectors, namely food crops sub-sector and annual crop sub-sector and other horticulture sub-sector; Pemali District has two sub-sectors, namely food crops and annual plantation sub-sector; Puding Besar District has one sub-sector that is the annual plantation sub-sector; Riau Silip District has two sub-sectors of base, namely food crop sub-sector and plantation sub-sector yearly; and Sungailiat District has three sub sectors namely horticulture and annual crops sub sector, fishery sub-sector, and livestock sub-sector.
Efficiency and Safety
Authors: Steiner Samuel R.H. , Gendi Kirollos , Halanski Matthew A. , Noonan Kenneth J.
Published: April 2018

Background:

The act of applying, univalving, and spreading a plaster cast to accommodate swelling is commonly performed; however, cast saws can cause thermal and/or abrasive injury to the patient. This study aims to identify the optimal time to valve a plaster cast so as to reduce the risk of cast-saw injury and increase spreading efficiency.

Methods:

Plaster casts were applied to life-sized pediatric models and were univalved at set-times of 5, 8, 12, or 25 minutes. Outcome measures included average and maximum force applied during univalving, blade-to-skin touches, cut time, force needed to spread, number of spread attempts, spread completeness, spread distance, saw blade temperature, and skin surface temperature.

Results:

Casts allowed to set for ≥12 minutes had significantly fewer blade-to-skin touches compared with casts that set for <12 minutes (p < 0.001). For average and maximum saw blade force, no significant difference was observed between individual set-times. However, in a comparison of the shorter group (<12 minutes) and the longer group (≥12 minutes), the longer group had a higher average force (p = 0.009) but a lower maximum force (p = 0.036). The average temperature of the saw blade did not vary between groups. The maximum force needed to “pop,” or spread, the cast was greater for the 5-minute and 8-minute set-times. Despite requiring more force to spread the cast, 0% of attempts at 5 minutes and 54% of attempts at 8 minutes were successful in completely spreading the cast, whereas 100% of attempts at 12 and 25 minutes were successful. The spread distance was greatest for the 12-minute set-time at 5.7 mm.

Conclusions:

Allowing casts to set for 12 minutes is associated with decreased blade-to-skin contact, less maximum force used with the saw blade, and a more effective spread.

Clinical Relevance:

Adherence to the 12-minute interval could allow for fewer cast-saw injuries and more effective spreading.
Conflict-of-Interest Disclosures to The Journal of Bone & Joint Surgery
Authors: Fu Michael C. , Boddapati Venkat , Nwachukwu Benedict U. , Ranawat Anil S. , Albert Todd J. , Dines Joshua S.
Published: April 2018

Background:

Academic journals such as The Journal of Bone & Joint Surgery (JBJS) require disclosures of financial relationships that authors report as potential conflicts of interest. Because industry payments can take various forms, including food and beverage, consulting, or research payments, the purpose of this study was to determine which categories of industry-reported payments were most frequently considered by authors as irrelevant to their specific publication, and therefore not included in their journal disclosures.

Methods:

Author disclosures were collected from scientific articles published in JBJS in 2016. Payments reported by authors as relevant to the published article were compared with industry-reported payments from the Centers for Medicare & Medicaid Services Open Payments Database (OPD), which includes all payments to eligible physicians in the United States. The number of authors with payments found in the OPD and appearing in publication-specific disclosures was determined for each payment type. Of note, OPD data are not indicative of relevance to a particular publication; therefore, the accuracy of author disclosures could not be determined in this study.

Results:

A total of 747 eligible authors were included; 60.5% of authors did not report at least 1 payment from their OPD report in their publication-specific disclosures, most frequently representing industry payments for food and beverage (55.7%), followed by travel and lodging (26.9%). Payments for consulting (16.3%), royalties (8.2%), research (8.4%), and ownership interests (1.5%) were not considered to be relevant disclosures for specific journal articles by authors at lower rates than those for food and beverage and for travel and lodging.

Conclusions:

Authors publishing in JBJS were more likely to conclude that industry-reported payments in the OPD for food and beverage and for travel and lodging were irrelevant for specific publications (as disclosed to the journal) than payments for consulting, royalties, research, and ownership interests.
Idiopathic Toe-Walking: Prevalence and Natural History from Birth to Ten Years of Age
Authors: Engström Pähr , Tedroff Kristina
Published: April 2018

Background:

Children with idiopathic toe-walking, a common pediatric condition, walk some or all of the time on their toes. This condition often causes parental concern, with repeated medical contacts and a range of interventions including stretching, casts, injection of botulinum toxin A, and surgical procedures. The purpose of this cohort study was to document the natural history of this condition.

Methods:

In a population-based cohort of 1,401 healthy 5.5-year-old Swedish children, we found the prevalence of idiopathic toe-walking to be approximately 5% (63 of 1,401). Of the 63 children who had ever been a toe-walker, 26 still were at the age of 5.5 years and were followed in the current study at 8 and 10 years of age. At the 8-year follow-up, parents were asked by telephone whether their child had received any treatment or diagnosis since the 5.5-year assessment, as well as to what extent (approximately 25%, 50%, 75%, or 100% of the time) the child still walked on the toes. At the visit when the children were 10 years of age, their parents were asked the same questions. All 26 children also underwent a neurological examination and an orthopaedic examination focusing on the lower extremities.

Results:

At 8 years of age, 6 of 26 children had ceased toe-walking, and by the age of 10 years, 50 (79%) of the original 63 patients had spontaneously ceased toe-walking. Idiopathic toe-walking did not result in contractures of the triceps surae. One subgroup of children displayed early contracture of the ankle and should thus not be considered idiopathic toe-walkers. Four of the children who still toe-walked at the age of 10 years demonstrated some neurodevelopmental comorbidity.

Conclusions:

By the age of 10 years, 79% of the children who have ever been a toe-walker spontaneously develop a typical gait, without intervention or contractures of the ankle dorsiflexion. The diagnosis of short tendo Achilles should be retained as a separate diagnosis as there is a subset of children with this entity who should be treated early in childhood. Neurodevelopmental comorbidities are common among those who continue to toe-walk.

Level of Evidence:

Prognostic Level I. See Instructions for Authors for a complete description of levels of evidence.
An Interpretation of Microseismic Spatial Anomalies,b-values, and Magnitude Analyses To Identify Activated Fracture Networks in Horn River Basin
Authors: Yousefzadeh Abdolnaser , Li Qi , Virues Claudio , Aguilera Roberto
Published: April 2018

We analyzed microseismic spatial and temporal distribution, magnitudes, b-values, and treatment data to interpret and explain the observed anomalies in microseismic events recorded during exploitation of shale gas reservoirs in the Horn River Basin of Canada. The b-value shows the relationship between the number of seismic events in a certain area and their magnitudes in a semilogarithmic scale. The b-value is important because small changes in b-value represent large changes in the predicted number of seismic events. In this study, b-value is considered as an indicator of the mechanism of observed microseismicity during hydraulic-fracturing treatments.

We estimated the directional diffusivity to define the microseismicity front curve for each stage of hydraulic fracturing. On the basis of our definition of an average front curve, we managed to separate most of the microseismic events that are related to natural-fracture activation from hydraulic-fracturing microseismic events. We analyzed b-values for microseismic events of each stage before and after separating fracture-activation microseismic events from original data, and created a map of b-values in the study area. This allowed us to approximately locate activated fractures mostly in the northeastern part of the study wellpad. The b-value map agrees with our assumption of activated-fracture locations and high ratio of seismic activities. The dominant direction of the suggested activated natural fractures agrees with the general trend of the Trout Lake fault zone located approximately 20 km west of the study area.

Suggested fracture direction also agrees with anomalous-events density, energy distribution, and treatment data. We are proposing intermediate b-values for calculation of the stimulated reservoir volume (SRV) in areas with both hydraulically fractured events and events related to natural-fracture-network activation in those instances in which it is not viable to separate events based on their origin.
Quantitatively Assessing Hydrate-Blockage Development During Deepwater-Gas-Well Testing
Authors: Wang Zhiyuan , Zhao Yang , Zhang Jianbo , Wang Xuerui , Yu Jing , Sun Baojiang
Published: April 2018

Hydrate-associated problems pose a key concern to the oil and gas industry when moving toward deeper-offshore reservoir development. A better understanding of hydrate-blockage-development behavior can help flow-assurance engineers develop more-economical and environmentally friendly hydrate-management strategies for deepwater operations. In this work, a model is proposed to describe the hydrate-blockage-formation behavior in testing tubing during deepwater-gas-well testing. The reliability of the model is verified with drillstem-testing (DST) data. Case studies are performed with the proposed model. They indicate that hydrates form and deposit on the tubing walls, creating a continuously growing hydrate layer, which narrows the tubing, increases the pressure drop, and finally results in conduit blockage. The hydrate-layer thickness is nonuniform. At some places, the hydrate layer grows more quickly, and this is the high-blockage-risk region (HBRR). The HBRR is not located where the lowest ambient temperature is encountered, but rather at the position where maximum subcooling of the produced gas is presented. As an example case—a deepwater gas well with a water depth of 1565 m and a gas-production rate of 45 × 104 m3/d—the hydrate blockage first forms at the depth of 150 m. In the section with a depth from 50 to 350 m, hydrates deposit more rapidly and this is the HBRR. As the water depth increases and/or the gas-flow rate decreases, the HBRR becomes deeper. Inhibitors can delay the occurrence of hydrate blockage. The hydrate problems can be handled with a smaller amount of inhibitors during deepwater well-testing operations. This work provides new insights for engineers to develop a new-generation flow-assurance technique to handle hydrate-associated problems during deepwater operations.
Productivity-Index Behavior for Hydraulically Fractured Reservoirs Depleted by Constant Production Rate Considering Transient-State and Semisteady-State Conditions
Authors: Al-Rbeawi Salam
Published: April 2018

This paper introduces a new approach for studying productivity-index (PI) behavior of fractured oil and gas reservoirs during transient-and pseudosteady-state conditions. This approach focuses on the fact that PI derivative could vanish at a certain production time, indicating the beginning of pseudosteady state, wherein the PI demonstrates constant value. The reservoirs in this study are considered depleted by horizontal wells intersecting multiple hydraulic fractures where Darcy flow and non-Darcy flow may control flow patterns in the porous media. The PI is calculated assuming constant production rate and considering pressure profile for early- and intermediate-production time when transient condition dominates fluid flow and late-production time when pseudosteady state is reached.

The outcomes of this study can be summarized as understanding PI behavior at early- and intermediate-production time when transient flow is dominant in the porous media and late-production time when pseudosteady-state condition is reached; indicating the effect of reservoir configuration on PI and the time when this index approaches constant value; and introducing a study for the influence of non-Darcy flow in the PI.

The most-interesting points in this study are the following. First, that PI reaches constant value when the rates of change with time for the two pressure drops—transient and pseudosteady state—are equal. Second, the time for approaching constant PI in a small drainage area is faster than for a large area. Third, that PI is affected by non-Darcy flow at early- and intermediate-production time; however, the effect is not seen at late-production time. Last, that PI could exhibit constant behavior for severe non-Darcy flow at early- and intermediate-production times even though transient-state condition dominates fluid flow in the porous media.
Predicting Sucker-Rod Pumping Systems With Fourier Series
Authors: Chen Zengshi , White Luther W. , Zhang Huimin
Published: April 2018

The Fourier-series method (FSM) is used to solve the prediction problems of sucker-rod pumping systems. With the displacement and load at any point of the rod string, by means of FSM, the displacement and load at any other point of the rod string are obtained. With no need of pump models, FSM easily predicts various pumping conditions that are challenges to the conventional prediction methods. As for prediction, FSM is valuable to the design, selection, installation, and operation of sucker-rod pumping systems. As for diagnostics, the surface cards generated by FSM can be used as characteristic surface cards for diagnosis of the sucker-rod pumping systems in situations when only the surface cards are available. FSM is also a convenient method to generate surface cards for pump-diagnostic emulators in the laboratory environment.
Consequence Quantification of Barrier System Failures in Permanently Plugged and Abandoned Wells
Authors: Ford Eric , Moeinikia Fatemeh , Majoumerd Mohammad Mansouri , Lohne Hans Petter , Arild Øystein
Published: April 2018

Plug & abandonment (P&A) regulations on the Norwegian continental shelf are largely prescriptive, since the same requirements are applied irrespective of well conditions. A risk-based approach on the other hand, is a well-specific approach to assess the quality of a given plug and abandonment design solution. Probability of leakage and consequence, in the form of leakage rates to the environment, should be quantified for permanently plugged and abandoned wells in a risk-based approach.

To address the consequence aspect of a risk-based approach, a tool for quantitative leakage assessment is essentially needed. This should cover all leakage pathways for reservoir fluids to the environment, i.e. leakage through the well and leakage outside the well through the surrounding formation. The integrity of the cement barrier could be weakened as a result of e.g. poor slurry design, tensile stresses and shrinkage, creating leakage pathways through the bulk cement, cracks and micro-annuli along cement interfaces. As for the surrounding formation, geological features such as faults and fractures, as well as the sealing ability of the cap rock, are important factors to consider from a barrier integrity perspective. Fractures or faults might intersect a permeable formation at a shallow depth, potentially enabling reservoir fluids to migrate into the wellbore or to the seabed.

The authors have developed a leakage assessment simulator, to quantify leakage rates for permanently plugged and abandoned wells. The structure and models incorporated in the preliminary version of the simulator, covering only leakage pathways through the wellbore, was previously presented in SPE-185890-MS.

The current study builds on the previous paper by also accounting for leakage scenarios outside the well through the surrounding formation. The structure of the leakage assessment simulator is also presented in this paper. Additionally, features that may significantly reduce leakage rates, such as barite plug are addressed. A synthetic case is presented where leakage rate is estimated for two scenarios, a) leakage through the well only and b) leakage through the well and the surrounding formation.
Nonintrusive Determination of Top of Cement and Wellbore Blockage Depth Using Pressure Wave Analysis
Authors: Stewart Neil , Jack Graham
Published: April 2018

Current methods for determining the depth to the top of cement (TOC), blockages, or wellbore features are limited to intrusive applications that require a significant amount of associated time, equipment, risk, and cost. This is a long-standing challenge to operators, particularly when critical decisions need to be made to promptly verify downhole status or remediate flow restrictions to restore production. This paper details a systematic, comprehensive, and proven solution to these challenges using pressure wave analysis.

The method is based on analyzing the return reflections generated by a pressure wave transiting the well to and from the blockage location. By capturing high-resolution pressure measurement on an ultrahigh-speed logger, the generated pressure wave can be recorded for analysis. Applying acoustic velocity gradient modeling in conjunction with effects of the well and fluid medium, the distance from the recording location to the blockage can be accurately determined without the use of intrusive or localized external tools.

This work shows that the method theory is substantiated by results observed when used during a controlled full-scale field trial in addition to subsequent activities to locate blockages and features within actual wells. A case study is presented demonstrating that the method can be used to identify where a blockage or feature is located. The theoretical method for calculation of acoustic velocity for known system and fluid parameters is shown to be accurate within tolerances compared to the acoustic velocity obtained in the field by recording the time of flight between two known points. It is demonstrated that blockages can be detected to a level of accuracy up to 0.3% of system length, verified by comparison with known measured well construction details.

The method presented significantly differentiates itself from traditional depth determination systems and applications. It can provide information with a repeatable and verified level of accuracy without the need for costly and time-consuming intrusive intervention, which allows operators the opportunity to target remediation work in the most efficient and cost-effective manner.
New and Alternative Religions in Serbia – About the Study and the People Being Studied
Authors: Sinani Danijel , Kulenović Nina , Stajić Mladen
Published: April 2018

The paper represents the first results of research conducted within the Urban and cultural identity and religiosity in contemporary context and surroundings project. This paper is the first part of the study, and special attention will be given to results of previous research and the extent to which new and alternative religions have previously been studied in Serbia. The methods, approaches, themes and attempts at defining the concept and classifying phenomena pertaining to new and alternative religions in Serbian academia will be considered.
Of Football, Anthropology and Transition. Narratives about Violence and Safety in Contemporary Serbia
Authors: Đorđević Ivan
Published: April 2018

The aim of this paper is to determine the ways in which the culture one lives in is conceptualized through the understanding of modern football. The focus is on the overlapping and negotiation of identity politics determined by the local cultural context, while also taking note of the increasing globalization of the sport itself. Special attention will be given to the discourse on safety, it being one of the key narratives about modern football. By following the media narratives on the topic, especially those concerning the murder of the French supporter Brice Taton in Belgrade in 2009, I will attempt to point out the images which dominate the conceptualization of contemporary domestic football, and through this, the period of transition which Serbia is currently going through.
The Study of Music in Anthropology
Authors: Ristivojević Marija
Published: April 2018

Contemporary anthropology is characterized by a wide array of research topics, with music becoming an increasingly important field of study, which still remains unexplored, at least as far as the interrelationship of music and culture is concerned. However, it should be emphasized that music has been studied within the discipline in different ways. In that sense, the aim of this paper is to point out some of these differences, through taking the dominant theoretical postulates into account. The relevance of the concept of music for anthropological study is evident in the fact that it is a socio-cultural phenomenon which functions as both a cultural artifact and an active element through which different levels of cultural identification are shaped (the individual, collective, local, ethnic), which itself points to the fact that anthropologists themselves don’t necessarily need to engage with “traditional” music. Essentially, any type of music which means something to a group of people is fair game, as evidenced by the growing interest in the phenomenon of popular music in domestic as well as foreign scientific circles.
Assessing equity: a way to improve sanitation service delivery in South African informal settlements
Authors: Pan S. M. , Armitage N. P. , van Ryneveld M. B.
Published: April 2018

This paper discusses the need to incorporate equity assessment into the planning and monitoring of sanitation service delivery to South African informal settlements. Equity assessment criteria were drawn from literature and a study of sanitation service delivery to informal settlements in three South African municipalities (Cape Town, Johannesburg and eThekwini) over the period 2012–2015. Three key dimensions of equity – resource allocation, access and stakeholder perceptions – were identified. These had eight associated criteria: (1) funds allocated for basic sanitation, (2) number of staff allocated to informal settlements, (3) disparities in access, (4) proportion of functioning sanitation facilities, (5) menstrual hygiene management (MHM) inclusion, (6) access to information, (7) meets users' notions of dignity, and (8) integration of the perspectives of key stakeholders. Key findings of the study indicate that the current focus on reducing service backlogs largely ignores equity and there is a need to better address this through the incorporation of: equity assessments, improving access to information, and the inclusion of marginalised communities in the planning of sanitation services.
The effect of the mixing of water from different sources in the water supply system on tap water quality – a full-scale technical investigation case study
Authors: Szuster-Janiaczyk A. , Bylka J.
Published: April 2018

The paper presents a detailed analysis of the quality of water pumped into a network and sampled from 39 monitoring points located on the network. A difference in the quality of water sampled from two different sources was demonstrated, as well as the impact of the mixing of the two waters in the water distribution system (WDS) on tap water quality. A mathematical model was used to identify the zones of water mixing and the areas of unfavourable hydraulic conditions (low flow rates and long retention times).
Performance and adsorption mechanism of a magnetic calcium silicate hydrate composite for phosphate removal and recovery
Authors: Peng Lihong , Dai Hongliang , Wu Yifeng , Dai Zheqin , Li Xiang , Lu Xiwu
Published: April 2018

A novel magnetic calcium silicate hydrate composite (Fe3O4@CSH) was proposed for phosphorus (P) removal and recovery from a synthetic phosphate solution, facilitated by a magnetic separation technique. The Fe3O4@CSH material was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), powder Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), zeta-potential and magnetic curves. The chemical composition and structure of Fe3O4@CSH and the successful surface loading of hydroxyl functional groups were confirmed. Phosphate adsorption kinetics, isotherm, and thermodynamic experiments showed that adsorption reaches equilibrium at 24 h, with a maximum adsorption capacity of 55.84 mg P/g under optimized experimental conditions. Adsorption kinetics fitted well to the pseudo second-order model, and equilibrium data fit the Freundlich isotherm model. Thermodynamic analysis provided a positive value for ΔH° (129.84 KJ/mol) and confirmed that phosphate adsorption on these materials is endothermic. The P-laden Fe3O4@CSH materials could be rapidly separated from aqueous solution by a magnetic separation technique within 1 min. A removal rate of more than 60% was still obtained after eight adsorption/desorption cycles, demonstrating the excellent reusability of the particles. The results demonstrated that the Fe3O4@CSH materials had high P-adsorption efficiency and were reusable.
La herencia universitaria a 100 años de la reforma – debates y combates sobre su vigencia y perspectivas
Authors: Imen Pablo
Published: April 2018

El presente artículo se propone analizar, desde la perspectiva del siglo XXI, los acervos de la Reforma Universitaria de Córdoba, Argentina, el 15 de junio de 1918. En aquél entonces la reacción estudiantil contra una institución universitaria clerical, autoritaria y conservadora incluyó su crítica como una alternativa democratizadora que se expandió por América Latina. Durante el siglo XX hubo distintas experiencias que resultan aportes valiosos para pensar la Universidad del siglo XXI en el marco de la construcción de la Patria Grande a partir del reformismo y del nacionalismo popular revolucionario. La Declaración de Cartagena de Indias de 2008, por parte del Consejo Regional de Educación Superior (CRES) de la UNESCO recupera estas herencias, proponiendo rescates de su espíritu democratizador en los planos del gobierno, su proyecto pedagógico y su proyección hacia los contextos nacionales y regionales
Dualidade e ambivalência da identidade docente de bacharéis que atuam em cursos de licenciaturas
Authors: Pereira Diego Carlos , Costa Váldina Gonçalves da
Published: April 2018

Esse artigo resulta de uma pesquisa de mestrado focada no estudo da identidade docente de professores formadores, considerando a constituição da identidade como processo relacional individual e coletivo que permeia as trajetórias formativas e educacionais. O objetivo deste artigo é problematizar e argumentar a respeito das características duais e ambivalentes da constituição da identidade docente de professores bacharéis que atuam em cursos de Licenciatura, considerando os aspectos formais e biográficos das trajetórias dos sujeitos. O estudo pautou-se em perspectiva qualitativa a partir da metodologia da História oral e da análise das narrativas de professores formadores bacharéis. Defendemos que a dualidade do processo se caracteriza entre a formação bacharelesca e a atribuição ao cargo de docente conferida pela legislação educacional e pelo contexto acadêmico; enquanto a ambivalência se expressa por meio do conflito entre ser bacharel/pesquisador e ser professor no ensino superior, diante das demandas distintas que esses dois papeis profissionais podem provocar.
Editorial
Authors: Araujo Marta Maria
Published: April 2018

Editorial
Functional Cross-Talk between Adenosine and Metabotropic Glutamate Receptors
Authors: León-Navarro David Agustín , Albasanz José Luis , Martín Mairena
Published: April 2018

G-protein coupled receptors are transmembrane proteins widely expressed in cells and their transduction pathways are mediated by controlling second messenger levels through different G-protein interactions. Many of these receptors have been described as involved in the physiopathology of neurodegenerative diseases and even considered as potential targets for the design of novel therapeutic strategies. Endogenous and synthetic allosteric and orthosteric selective ligands are able to modulate GPCRs at both gene and protein expression levels and can also modify their physiological function. GPCRs that coexist in the same cells can homo- and heteromerize, therefore, modulating their function. Adenosine receptors are GPCRs which stimulate or inhibit adenylyl cyclase activity through Gi/Gs protein and are involved in the control of neurotransmitter release as glutamate. In turn, metabotropic glutamate receptors are also GPCRs which inhibit adenylyl cyclase or stimulate phospholipase C activities through Gi or Gq proteins, respectively. In recent years, evidence of crosstalk mechanisms between different GPCRs have been described. The aim of the present review was to summarize the described mechanisms of interaction and crosstalking between adenosine and metabotropic glutamate receptors, mainly of group I, in both in vitro and in vivo systems, and their possible use for the design of novel ligands for the treatment of neurodegenerative diseases.
Flavones and Their Analogues as Bioactive Compounds – An Overview
Authors: Jayashree B.S. , Venkatachalam H. , Mallik Sanchari Basu
Published: April 2018

Flavonoids constitute a large group of polyphenolic compounds that are known to have antioxidant properties, through their free radical scavenging abilities. They possess a chromone (γ- benzopyrone) moiety, responsible for eliciting many pharmacological activities. Even though, natural flavonoids are highly potent, owing to their poor solubility, they are less used. Therefore, attempts have been made to improve their stability, solubility, efficacy and kinetics by introducing various substituents on the flavone ring. For nearly the last two decades, flavones were synthesized in our laboratory by simple, convenient and cost-effective methods, with the knowledge of both synthetic and semi-synthetic chemistry. In this direction, it was considered worthwhile to present an overview on the synthesized flavonoids. This review creates a platform for highlighting various modifications done on the flavone system along with their biological activity.
Flipped Learning: Can Rheumatology Lead the Shift in Medical Education?
Authors: El-Miedany Yaseer , El-Gaafary Maha , El-Aroussy Nadia , Youssef Sally
Published: April 2018

Objective: To 1. implement flipped classroom rheumatology teaching for undergraduate
education. 2. Evaluate outcomes of teaching using OSCE assessment and student perceived effectiveness
and satisfaction survey.

Methods:

The flipped classroom education, 55-students, was conducted in 3 phases. Phase 1: Carried
out in the students’ own time. Web links were emailed to assist exposure of the instructional
part of the lesson online. Phase 2: Interactive in-class activity to share personal reflection and reinforce
the key aspects. Phase 3: A simulated OSCE assessment. A cohort of 56-students, who were
taught in the last educational year on the same topics according to standard teaching protocols,
were included as control group. The clinical Outcomes were assessed using the scores of the OSCE
examination model. Academic outcomes included the engagement measure as well as the students’
answers to perceived effectiveness and satisfaction survey.

Results:

There was no significant difference regarding demographics between the 2 students’
groups. There was a significant improvement (p< 0.05) in the flipped learning, in contrast to the
control group, in terms of clinical (OSCE score) as well as communication skills. Student perceived
effectiveness and satisfaction was significantly higher among the flipped learning (p< 0.05). Scores
from the flipped learning cohort showed a state of engagement significantly higher than the control
group (p< 0.01).

Conclusion:

Flipped learning implementation musculoskeletal learning successfully demonstrated
a promising platform for using technology to make better use of the students' time, and for increasing
their satisfaction. Active learning increases student engagement and can lead to improved retention
of knowledge.
Utilizing Cancer - Functional Gene Set - Compound Networks to Identify Putative Drugs for Breast Cancer
Authors: Hsiao Tzu-Hung , Chiu Yu-Chiao , Chen Yu-Heng , Hsu Yu-Ching , Chen Hung-I Harry , Chuang Eric Y. , Chen Yidong
Published: April 2018

Aim and Objective:

The number of anticancer drugs available currently is limited, and
some of them have low treatment response rates. Moreover, developing a new drug for cancer
therapy is labor intensive and sometimes cost prohibitive. Therefore, “repositioning” of known
cancer treatment compounds can speed up the development time and potentially increase the
response rate of cancer therapy. This study proposes a systems biology method for identifying new
compound candidates for cancer treatment in two separate procedures.

Materials and Methods:

First, a “gene set–compound” network was constructed by conducting gene
set enrichment analysis on the expression profile of responses to a compound. Second, survival
analyses were applied to gene expression profiles derived from four breast cancer patient cohorts to
identify gene sets that are associated with cancer survival. A “cancer–functional gene set–
compound” network was constructed, and candidate anticancer compounds were identified. Through
the use of breast cancer as an example, 162 breast cancer survival-associated gene sets and 172
putative compounds were obtained.

Results:

We demonstrated how to utilize the clinical relevance of previous studies through gene sets
and then connect it to candidate compounds by using gene expression data from the Connectivity
Map. Specifically, we chose a gene set derived from a stem cell study to demonstrate its association
with breast cancer prognosis and discussed six new compounds that can increase the expression of
the gene set after the treatment.

Conclusion:

Our method can effectively identify compounds with a potential to be “repositioned”
for cancer treatment according to their active mechanisms and their association with patients’
survival time.
Wprowadzenie do nowych obrzędów pogrzebowych
Authors: Święta Kongregacja Kultu Bożego
Published: April 2018

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Nowe obrzędy pogrzebu i związane z nimi problemy prawno-liturgiczne
Authors: Michałek Roman
Published: April 2018

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Ewangelia księgą Roku Świętego
Authors: Smereka Władysław
Published: April 2018

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Szkice homilii chrzcielnych (II)
Authors: Chmiel Jerzy
Published: April 2018

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Rodzaje nowotestamentalnej typologii Mojżesz–Chrystus
Authors: Jelonek Tomasz
Published: April 2018

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Odwieczne pochodzenie Słowa (J 1, 1–5)
Authors: Stachowiak Lech
Published: April 2018

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Odnowiony ryt chrześcijańskiego pogrzebu
Authors: Szamota Stanisław
Published: April 2018

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Program nauczania muzyki kościelnej w seminariach duchownych w Polsce
Authors: Pawlak Ireneusz
Published: April 2018

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Jak należy rozumieć „divina mysteria” w orędziu wielkanocnym?
Authors: Bzowski Stanisław
Published: April 2018

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Zmiany w obchodzie świąt maryjnych
Authors: Pisarzak Marian
Published: April 2018

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Szkice homilii żałobnych (II)
Authors: Chmiel Jerzy
Published: April 2018

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Rozwój archeologiczno-egzegetycznyna przestrzeni ostatnich 25 lat
Authors: North Robert
Published: April 2018

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Postać Mojżesza w Nowym Testamencie
Authors: Jelonek Tomasz
Published: April 2018

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Wymowa obrzędu przygotowania darów
Authors: Nadolski Bogusław
Published: April 2018

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Hymny pasyjne w Pierwszym Liście św. Piotra
Authors: Langkammer Hugolin
Published: April 2018

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Apostolstwo w ujęciu biblijnym
Authors: Stępień Jan
Published: April 2018

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Theory-Based Predictors of Mindfulness Meditation Mobile App Usage: A Survey and Cohort Study (Preprint)
Authors: Crandall AliceAnn , Cheung Aaron , Young Ashley , Hooper Audrey P
Published: April 2018

BACKGROUND

Mindfulness meditation has become increasingly popular over the last few years, due in part to the increase in mobile apps incorporating the practice. Although studies have demonstrated the potential of mindfulness meditation to positively impact health, little has been uncovered about what predicts engagement in mindfulness meditation. Understanding the predictors of mindfulness meditation may help practitioners and phone app developers improve intervention strategies and app experience.

OBJECTIVE

The purpose of this study was to use the Theory of Planned Behavior and Temporal Self-Regulation Theory to determine factors predicting mindfulness meditation mobile app use.

METHODS

The sample consisted of 85 undergraduate students with no prior mindfulness meditation experience. During their first laboratory visit, participants completed tasks to measure their executive functioning and a survey to measure Theory of Planned Behavior constructs about mindfulness meditation. Over the following 2 weeks, participants logged the days and minutes that they practiced mindfulness meditation using a phone app. Hierarchical regression modeling was used to analyze the data.

RESULTS

After controlling for demographic factors, participant subjective norms (beta=14.51, P=.001) and intentions (beta=36.12, P=.001) were predictive of the number of minutes practicing mindfulness. Participant executive functioning did not predict mindfulness meditation practice, nor did it moderate the link between intentions and mindfulness meditation practice. Participant attitudes (beta=0.44, P<.001) and perceived control (beta=0.42, P=.002) were positively associated with intentions to practice mindfulness.

CONCLUSIONS

These results suggest that among college student populations, the Theory of Planned Behavior may be useful in predicting the use of mindfulness meditation phone apps. However, participant executive functioning was not a predictor or moderator of mindfulness practice, and Temporal Self-Regulation Theory may be less useful for explaining mindfulness meditation behaviors using phone apps over a short period of time among college students. The results have implications for public health professionals, suggesting that a focus on subjective norms and intentions may promote mindfulness meditation practice using phone apps.
Changes in Glomerular Filtration Rate and Impact on Long-Term Survival among Adults after Hematopoietic Cell Transplantation
Authors: Hingorani Sangeeta , Pao Emily , Stevenson Phil , Schoch Gary , Laskin Benjamin L. , Gooley Ted , McDonald George B.
Published: April 2018

Background and objectives

Kidney injury is a significant complication for patients undergoing hematopoietic cell transplantation (HCT), but few studies have prospectively examined changes in GFR in long-term survivors of HCT. We described the association between changes in GFR and all-cause mortality in patients up to 10 years after HCT.

Design, setting, participants, & measurements

We conducted a prospective, observational cohort study of adult patients undergoing HCT at the Fred Hutchinson Cancer Center in Seattle, Washington from 2003 to 2015. Patients were followed from baseline, before conditioning therapy, until a maximum of 10 years after transplant. We used Cox proportional hazard models to examine the association between creatinine eGFR and all-cause mortality. We used time-dependent generalized estimating equations to examine risk factors for decreases in eGFR.

Results

A total of 434 patients (median age, 52 years; range, 18–76 years; 64% were men; 87% were white) were followed for a median 5.3 years after HCT. The largest decreases in eGFR occurred within the first year post-transplant, with the eGFR decreasing from a median of 98 ml/min per 1.73 m2 at baseline to 78 ml/min per 1.73 m2 by 1 year post-HCT. Two thirds of patients had an eGFR<90 ml/min per 1.73 m2 at 1 year after transplant. When modeled as a continuous variable, as eGFR declined from approximately 60 ml/min per 1.73 m2, the hazard of mortality progressively increased relative to a normal eGFR of 90 ml/min per 1.73 m2 (P<0.001). For example, when compared with an eGFR of 90 ml/min per 1.73 m2, the hazard ratios for eGFR of 60, 50, and 40 ml/min per 1.73 m2 are 1.15 (95% confidence interval, 0.87 to 1.53), 1.68 (95% confidence interval, 1.26 to 2.24), and 2.67 (95% confidence interval, 1.99 to 3.60), respectively. Diabetes, hypertension, acute graft versus host disease, and cytomegalovirus infection were independently associated with a decline in GFR, whereas calcineurin inhibitor levels, chronic graft versus host disease, and albuminuria were not.

Conclusions

Adult HCT recipients have a high risk of decreased eGFR by 1 year after HCT. Although eGFR remains fairly stable thereafter, a decreased eGFR is significantly associated with higher risk of mortality, with a progressively increased risk as eGFR declines.
Feminismos latinoamericanos: deseo, cuerpo y biopolítica de lo materno
Authors: Arcos Herrera Carol
Published: April 2018

En el siguiente artículo realizo una lectura genealógica de los feminismos latinoamericanos, a partir de tres territorios conceptuales: el deseo, el cuerpo y lo que llamo biopolítica de lo materno, que me permiten indagar en uno de los grandes nudos gravitacionales para estos feminismos: la/s maternidad/es. Ensayo aquí un asunto controversial que sitúa, desde diferentes discursos y prácticas, el malestar y la insolencia feminista ante los interdictos patriarcales desde el siglo xix hasta la actualidad. Esto mediante la elección de ciertos momentos, a modo de escenas de simbolización, que me parecen claves para comprender las particularidades de los feminismos en la región.
Factors affecting healthy life style behaviors in workers working at a tea factory
Authors: ARDİC Cuneyt , YAVUZ Erdinc , ZEREN OZTURK Guzin
Published: April 2018

Introduction: The
objective of the present study was to determine educational level of the
workers of a tea factory on occupational health and safety and to reveal the
factors affecting a healthy lifestyle.Methods: The present
descriptive research was carried out in a tea factory where 352 workers are
employed between December 2016 and January 2017. 303 volunteer workers were
enrolled into the study and a questionnaire form including topics of
sociodemographic characteristics, occupational health and safety (OHS)
implementations, health state and working conditions that was developed through
literature information as well as Healthy Lifestyle Behaviors Scale (HLBS) were
used for data analysis.

Results: Age
average of the workers who were all male was 39.88±5.53. Among the workers,
70.29% were elementary school graduate and more than half of the participants
(62.70%) have a middle income (500-1,000 USD). Mean score of HLBS scale was
118.00±20.28 points. Average score of the sub-topics was the highest in health
responsibility item with 22.06 points whereas the lowest score was detected in
physical activity sub-topic.  It was
detected that 64.69% of the workers had an occupational health and safety
training at least once during their lifetime and 21.78% use a protective
equipment. Rate of exposure to work-related accidents was detected as 10.57%.
SUBALTERNIDADE E ABJEÇÃO DE PERSONAGENS TRAVESTIS NA LITERATURA BRASILEIRA
Authors: Fernandes Carlos Eduardo Albuquerque
Published: April 2018

O presente trabalho discute a condição de subalternidade e de abjeção na construção de personagens centrais travestis na literatura brasileira do século XX. Para tanto, tomamos por base a noção de sujeito subalterno de Spivak (2010) e de sujeito abjeto de Butler (2010), relacionando seu espaço de “fala” na literatura a partir da maneira como personagens circulam nas narrativas. Faremos menção a alguns contos e romances brasileiros do século XX, para discutir a condição de subalternidade e abjeção dessas protagonistas, que dividimos em três eixos de representações recorrentes nas obras estudadas: violências sofridas, exílio da família e de cidades de nascimento, situação socioeconômica. O objetivo é chegar a um argumento crítico sobre a recorrente situação de subalternidade das protagonistas travestis na literatura brasileira, corroborando uma possível relação de mimetização ou de realismo nessa faceta da literatura homoerótica com o que se verifica no âmago de sociedades patriarcais e heteronormativas.
NO BAÚ DE MIUDEZAS DE CIDINHA DA SILVA: UMA ESCRITA AFROFEMININA BIOGRAFEMÁTICA E HOMOERÓTICA
Authors: Raposo Leila Cunha , Amim Valéria
Published: April 2018

Em Baú de miudezas, sol e chuva, publicado em 2014, Cidinha da Silva, por meio de uma escrita afrofeminina, apresenta nas narrativas, ficção e traços biográficos entremeados, conduzindo às hibridas fronteiras dos gêneros discursivos e desvelando uma escrita também biografemática e homoerótica, tendo por base relações homoafetivas lésbicas entre mulheres negras. A partir dessas narrativas, objetivamos analisar a escrita afrofeminina, posto que defendemos que, entre os biografemas apresentados, há uma confluência entre as vivências biográficas da autora e sua escrita literária, bem como são revelados aos leitores pormenores que conduzem à temática homocultural, a par das relações lésbicas tematizadas. Pautamo-nos na apreciação teórico-crítica existente quanto aos estudos biográficos e homoculturais, bem como à literatura afro-brasileira. Como conclusões prévias desse estudo, realizado com metodologia qualitativa de caráter bibliográfico, acreditamos que os biografemas permitem entrever tanto a construção de um amor homoerótico feminino quanto discussões de gênero e etnia que perpassam pelo empoderamento de mulheres negras.
A HORA PRESENTE: ENCENANDO A DOR E O SILÊNCIO EM A HORA DA ESTRELA
Authors: Miguel Fernanda Valim Côrtes
Published: April 2018

Neste artigo buscamos realizar uma leitura do romance A hora da estrela (1977), de Clarice Lispector, em contribuição ao dossiê que homenageia os 40 anos de sua primeira publicação no Brasil. As reflexões apontam para o modo como a estrutura narrativa, sua tematização e o tensionamento dos limites da linguagem dão voz aos sons musicais e ao silêncio, criando outras sonoridades possíveis, diferentes daquela que embala a poética da civilização moderna. A hora presente, marcada ao longo de todo o relato, pontuaria uma profunda consciência do escritor/escritora sobre a escuridão de seu próprio tempo. De maneira análoga, este “hoje” demarcaria a trágica vida de Macabéa, destituída de experiências passadas e de um projeto de futuro possível. Nesse sentido, a personagem estaria presa entre o início e o fim, presa na hora exata de um silencioso e doloroso presente.