bluuebunny/crossref_metadata_2025 huggingface dataset:
Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer
Authors: Zhou Yuan , Sakai Makoto , Li Yang , Kubota Yoshiki , Okamoto Masahiko , Shiba Shintaro , Okazaki Shohei , Matsui Toshiaki , Ohno Tatsuya
Published: April 2023

Carbon-ion radiotherapy (CIRT) is one of the most effective radiotherapeutic modalities. This study aimed to select robust-beam configurations (BC) by water equivalent thickness (WET) analysis in passive CIRT for pancreatic cancer. The study analyzed 110 computed tomography (CT) images and 600 dose distributions of eight patients with pancreatic cancer. The robustness in the beam range was evaluated using both planning and daily CT images, and two robust BCs for the rotating gantry and fixed port were selected. The planned, daily, and accumulated doses were calculated and compared after bone matching (BM) and tumor matching (TM). The dose-volume parameters for the target and organs at risk (OARs) were evaluated. Posterior oblique beams (120–240°) in the supine position and anteroposterior beams (0° and 180°) in the prone position were the most robust to WET changes. The mean CTV V95% reductions with TM were −3.8% and −5.2% with the BC for gantry and the BC for fixed ports, respectively. Despite ensuring robustness, the dose to the OARs increased slightly with WET-based BCs but remained below the dose constraint. The robustness of dose distribution can be improved by BCs that are robust to ΔWET. Robust BC with TM improves the accuracy of passive CIRT for pancreatic cancer.
A Boom in Nanotechnologies for a High Level of Precision Medicine
Authors: Angeli Eurydice , Bousquet Guilhem
Published: April 2023

The number of publications on nanomedicine in oncology has been exponential over the last ten years, going from 640 publications in 2012 to 2487 publications in 2022, reflecting the growing interest and potential of these new technologies [...]
Mutations in Homologous Recombination Genes and Loss of Heterozygosity Status in Advanced-Stage Breast Carcinoma
Authors: Bartow Brooke B. , Siegal Gene P. , Yalniz Ceren , Elkhanany Ahmed M. , Huo Lei , Ding Qingqing , Sahin Aysegul A. , Guo Hua , Magi-Galluzzi Cristina , Harada Shuko , Huang Xiao
Published: April 2023

Poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPis) have demonstrated antitumor activity in cancers with a homologous recombination deficiency (HRD) and have recently been approved by the FDA for the treatment of germline BRCA1/2-mutation-associated breast cancer. PARPis have also been found to be efficacious in BRCA wild-type (BRCAwt) lesions with high genomic loss of heterozygosity (LOH-high). The goal of this study was to retrospectively investigate the tumor mutations in homologous recombination (HRR) genes and the LOH score in advanced-stage breast carcinomas (BCs). Sixty-three patients were included in our study, 25% of whom had HRR gene mutations in their tumors, including 6% BRCA1/2 and 19% non-BRCA-containing gene mutations. An HRR gene mutation was associated with a triple-negative phenotype. Twenty-eight percent of the patients had an LOH-high score, which, in turn, was associated with a high histological grade, a triple-negative phenotype, and a high tumor mutational burden (TMB). Among the six patients who received PARPi therapy, one had a tumor with a PALB2 mutation other than BRCA and had a clinical partial response. Twenty-two percent of the LOH-low tumors had BRCAwt–HRR gene mutations, compared with 11% of the LOH-high tumors. Comprehensive genomic profiling revealed a subset of breast cancer patients with a BRCAwt–HRR gene mutation that would be missed by an LOH test. The necessity of next-generation sequencing coupled with HRR gene analysis for PARPi therapy requires further investigation in clinical trials.
The Challenges of Treating Patients with Breast Cancer and Obesity
Authors: LeVee Alexis , Mortimer Joanne
Published: April 2023

Obesity is defined as a body mass index (BMI) of 30 kg/m2 or more and is associated with worse outcomes in patients with breast cancer, resulting in an increased incidence of breast cancer, recurrence, and death. The incidence of obesity is increasing, with almost half of all individuals in the United States classified as obese. Patients with obesity present with unique pharmacokinetics and physiology and are at increased risk of developing diabetes mellitus and cardiovascular disease, which leads to specific challenges when treating these patients. The aim of this review is to summarize the impact of obesity on the efficacy and toxicity of systemic therapies used for breast cancer patients, describe the molecular mechanisms through which obesity can affect systemic therapies, outline the existing American Society of Clinical Oncology (ASCO) guidelines for treating patients with cancer and obesity, and highlight additional clinical considerations for treating patients with obesity and breast cancer. We conclude that further research on the biological mechanisms underlying the obesity–breast cancer link may offer new treatment strategies, and clinicals trials that focus on the treatment and outcomes of patients with obesity and all stages of breast cancer are needed to inform future treatment guidelines.
Role of Hemidesmosomes in Oral Carcinogenesis: A Systematic Review
Authors: Nguyen Jordan , Chong Tze Wei , Elmi Hafsa , Ma Jiani , Madi John , Mamgain Asha , Melendez Eileen , Messina Julian , Mongia Nikhil , Nambiar Sanjana , Ng Tsu Jie , Nguyen Huy , McCullough Michael , Canfora Federica , O’Reilly Lorraine A. , Cirillo Nicola , Paolini Rita , Celentano Antonio
Published: April 2023

Background: Oral cancers have limited diagnostic tools to aid clinical management. Current evidence indicates that alterations in hemidesmosomes, the adhesion complexes primarily involved in epithelial attachment to the basement membrane, are correlated to cancer phenotype for multiple cancers. This systematic review aimed to assess the experimental evidence for hemidesmosomal alterations, specifically in relation to oral potentially malignant disorders and oral squamous cell carcinomas. Methods: We conducted a systemic review to summarise the available literature on hemidesmosomal components and their role in oral pre-cancer and cancer. Relevant studies were retrieved from a comprehensive search of Scopus, Ovid MEDLINE, Ovid Embase and Web of Science. Results: 26 articles met the inclusion criteria, of which 19 were in vitro studies, 4 in vivo studies, 1 in vitro and in vivo study, and 2 in vitro and cohort studies. Among them, 15 studies discussed individual alpha-6 and/or beta-4 subunits, 12 studies discussed the alpha-6 beta-4 heterodimers, 6 studies discussed the entire hemidesmosome complex, 5 studies discussed bullous pemphigoid-180, 3 studies discussed plectin, 3 studies discussed bullous pemphigoid antigen-1 and 1 study discussed tetraspanin. Conclusion: Heterogeneity in cell type, experimental models, and methods were observed. Alterations in hemidesmosomal components were shown to contribute to oral pre-cancer and cancer. We conclude that there is sufficient evidence for hemidesmosomes and their components to be potential biomarkers for evaluating oral carcinogenesis.
Incidence and Prognostic Impact of Deleterious Germline Mutations in Primary Advanced Ovarian Carcinoma Patients
Authors: Imterat Majdi , Harter Philipp , Rhiem Kerstin , Heitz Florian , Schneider Stephanie , Concin Nicole , Moubarak Malak , Welz Julia , Vrentas Vasileios , Traut Alexander , Hahnen Eric , Schmutzler Rita , du Bois Andreas , Ataseven Beyhan
Published: April 2023

Data on deleterious variants in genes other than BRCA1/2 remain limited. A retrospective cohort study was performed, including primary OC cases with TruRisk® germline gene panel testing between 2011 and 2020. Patients with testing after relapse were excluded. The cohort was divided into three groups: (A) no mutations, (B) deleterious BRCA1/2 mutations, and (C) deleterious mutations in other genes. A total of 702 patients met the inclusion criteria. Of these 17.4% (n = 122) showed BRCA1/2 mutations and a further 6.0% (n = 42) in other genes. Three-year overall survival (OS) of the entire cohort was significantly longer in patients with germline mutations (85%/82.8% for cohort B/C vs. 70.2% for cohort A, p < 0.001) and 3-year progression-free survival (PFS) only for cohort B (58.1% vs. 36.9%/41.6% in cohort A/C, p = 0.002). In multivariate analysis for the subgroup of advanced-stages of high-grade serous OC, both cohorts B/C were found to be independent factors for significantly better outcome, cohort C for OS (HR 0.46; 95% CI 0.25–0.84), and cohort B for both OS and PFS (HR 0.40; 95% CI 0.27–0.61 and HR 0.49; 95% CI 0.37–0.66, respectively). Germline mutations were detected in a quarter of OC patients, and a quarter of those in genes other than BRCA1/2. Germline mutations demonstrate in our cohort a prognostic factor and predict better prognosis for OC patients.
Significance of Cancer-Associated Fibroblasts in the Interactions of Cancer Cells with the Tumor Microenvironment of Heterogeneous Tumor Tissue
Authors: Arima Yoshimi , Matsueda Satoko , Saya Hideyuki
Published: April 2023

The tumor microenvironment (TME) plays a key role in cancer development and progression, as well as contributes to the therapeutic resistance and metastasis of cancer cells. The TME is heterogeneous and consists of multiple cell types, including cancer-associated fibroblasts (CAFs), endothelial cells, and immune cells, as well as various extracellular components. Recent studies have revealed cross talk between cancer cells and CAFs as well as between CAFs and other TME cells, including immune cells. Signaling by transforming growth factor-β, derived from CAFs, has recently been shown to induce remodeling of tumor tissue, including the promotion of angiogenesis and immune cell recruitment. Immunocompetent mouse cancer models that recapitulate interactions of cancer cells with the TME have provided insight into the TME network and support the development of new anticancer therapeutic strategies. Recent studies based on such models have revealed that the antitumor action of molecularly targeted agents is mediated in part by effects on the tumor immune environment. In this review, we focus on cancer cell–TME interactions in heterogeneous tumor tissue, and we provide an overview of the basis for anticancer therapeutic strategies that target the TME, including immunotherapy.
Steroid-Refractory Immune-Related Adverse Events Induced by Checkpoint Inhibitors
Authors: Tomsitz Dirk , Ruf Theresa , Zierold Sarah , French Lars E. , Heinzerling Lucie
Published: April 2023

The occurrence, second-line management and outcome of sr/sd-irAEs was investigated in patients with skin cancer. All skin cancer patients treated with immune checkpoint inhibitors (ICIs) between 2013 and 2021 at a tertiary care center were analyzed retrospectively. Adverse events were coded by CTCAE version 5.0. The course and frequency of irAEs were summarized using descriptive statistics. A total of 406 patients were included in the study. In 44.6% (n = 181) of patients, 229 irAEs were documented. Out of those, 146 irAEs (63.8%) were treated with systemic steroids. Sr-irAEs and sd-irAEs (n = 25) were detected in 10.9% of all irAEs, and in 6.2% of ICI-treated patients. In this cohort, infliximab (48%) and mycophenolate mofetil (28%) were most often administered as second-line immunosuppressants. The type of irAE was the most important factor associated with the choice of second-line immunosuppression. The Sd/sr-irAEs resolved in 60% of cases, had permanent sequelae in 28% of cases, and required third-line therapy in 12%. None of the irAEs were fatal. Although these side effects manifest in only 6.2% of patients under ICI therapy, they impose difficult therapy decisions, especially since there are few data to determine the optimal second-line immunosuppression.
Insights into the Human Microbiome and Its Connections with Prostate Cancer
Authors: Munteanu Raluca , Feder Richard-Ionut , Onaciu Anca , Munteanu Vlad Cristian , Iuga Cristina-Adela , Gulei Diana
Published: April 2023

The human microbiome represents the diversity of microorganisms that live together at different organ sites, influencing various physiological processes and leading to pathological conditions, even carcinogenesis, in case of a chronic imbalance. Additionally, the link between organ-specific microbiota and cancer has attracted the interest of numerous studies and projects. In this review article, we address the important aspects regarding the role of gut, prostate, urinary and reproductive system, skin, and oral cavity colonizing microorganisms in prostate cancer development. Various bacteria, fungi, virus species, and other relevant agents with major implications in cancer occurrence and progression are also described. Some of them are assessed based on their values of prognostic or diagnostic biomarkers, while others are presented for their anti-cancer properties.
4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A
Authors: Houben Roland , Alimova Pamela , Sarma Bhavishya , Hesbacher Sonja , Schulte Carolin , Sarosi Eva-Maria , Adam Christian , Kervarrec Thibault , Schrama David
Published: April 2023

Merkel cell carcinoma (MCC) is frequently caused by the Merkel cell polyomavirus (MCPyV), and MCPyV-positive tumor cells depend on expression of the virus-encoded T antigens (TA). Here, we identify 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone (PHT)—a reported inhibitor of Aurora kinase A—as a compound inhibiting growth of MCC cells by repressing noncoding control region (NCCR)-controlled TA transcription. Surprisingly, we find that TA repression is not caused by inhibition of Aurora kinase A. However, we demonstrate that β-catenin—a transcription factor repressed by active glycogen synthase kinase 3 (GSK3)—is activated by PHT, suggesting that PHT bears a hitherto unreported inhibitory activity against GSK3, a kinase known to function in promoting TA transcription. Indeed, applying an in vitro kinase assay, we demonstrate that PHT directly targets GSK3. Finally, we demonstrate that PHT exhibits in vivo antitumor activity in an MCC xenograft mouse model, suggesting a potential use in future therapeutic settings for MCC.
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model
Authors: Filho Walbert Edson Muniz , Almeida-Souza Fernando , Vale André Alvares Marques , Victor Elis Cabral , Rocha Mirtes Castelo Branco , Silva Gabriel Xavier , Teles Amanda Mara , Nascimento Flavia Raquel Fernandes , Moragas-Tellis Carla Junqueira , Chagas Maria do Socorro dos Santos , Behrens Maria Dutra , Hardoim Daiana de Jesus , Taniwaki Noemi Nosomi , Lima Josélia Alencar , Abreu-Silva Ana Lucia , Gil da Costa Rui M. , Calabrese Kátia da Silva , Azevedo-Santos Ana Paula Silva de , Nascimento Maria do Desterro Soares Brandão
Published: April 2023

Euterpe oleracea (açaí) fruit has approximately 15% pulp, which is partly edible and commercialized, and 85% seeds. Although açaí seeds are rich in catechins—polyphenolic compounds with antioxidant, anti-inflammatory, and antitumor effects—almost 935,000 tons/year of seeds are discarded as industrial waste. This work evaluated the antitumor properties of E. oleracea in vitro and in vivo in a solid Ehrlich tumor in mice. The seed extract presented 86.26 ± 0.189 mg of catechin/g of extract. The palm and pulp extracts did not exhibit in vitro antitumor activity, while the fruit and seed extracts showed cytotoxic effects on the LNCaP prostate cancer cell line, inducing mitochondrial and nuclear alterations. Oral treatments were performed daily at 100, 200, and 400 mg/kg of E. oleracea seed extract. The tumor development and histology were evaluated, along with immunological and toxicological parameters. Treatment at 400 mg/kg reduced the tumor size, nuclear pleomorphism, and mitosis figures, increasing tumor necrosis. Treated groups showed cellularity of lymphoid organs comparable to the untreated group, suggesting less infiltration in the lymph node and spleen and preservation of the bone marrow. The highest doses reduced IL-6 and induced IFN-γ, suggesting antitumor and immunomodulatory effects. Thus, açaí seeds can be an important source of compounds with antitumor and immunoprotective properties.
Bone Morphogenetic Protein-4 Impairs Retinal Endothelial Cell Barrier, a Potential Role in Diabetic Retinopathy
Authors: Darwish Noureldien H. E. , Hussein Khaled A. , Elmasry Khaled , Ibrahim Ahmed S. , Humble Julia , Moustafa Mohamed , Awadalla Fatma , Al-Shabrawey Mohamed
Published: April 2023

Bone Morphogenetic Protein 4 (BMP4) is a secreted growth factor of the Transforming Growth Factor beta (TGFβ) superfamily. The goal of this study was to test whether BMP4 contributes to the pathogenesis of diabetic retinopathy (DR). Immunofluorescence of BMP4 and the vascular marker isolectin-B4 was conducted on retinal sections of diabetic and non-diabetic human and experimental mice. We used Akita mice as a model for type-1 diabetes. Proteins were extracted from the retina of postmortem human eyes and 6-month diabetic Akita mice and age-matched control. BMP4 levels were measured by Western blot (WB). Human retinal endothelial cells (HRECs) were used as an in vitro model. HRECs were treated with BMP4 (50 ng/mL) for 48 h. The levels of phospho-smad 1/5/9 and phospho-p38 were measured by WB. BMP4-treated and control HRECs were also immunostained with anti-Zo-1. We also used electric cell-substrate impedance sensing (ECIS) to calculate the transcellular electrical resistance (TER) under BMP4 treatment in the presence and absence of noggin (200 ng/mL), LDN193189 (200 nM), LDN212854 (200 nM) or inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2; SU5416, 10 μM), p38 (SB202190, 10 μM), ERK (U0126, 10 μM) and ER stress (Phenylbutyric acid or PBA, 30 μmol/L). The impact of BMP4 on matrix metalloproteinases (MMP2 and MMP9) was also evaluated using specific ELISA kits. Immunofluorescence of human and mouse eyes showed increased BMP4 immunoreactivity, mainly localized in the retinal vessels of diabetic humans and mice compared to the control. Western blots of retinal proteins showed a significant increase in BMP4 expression in diabetic humans and mice compared to the control groups (p < 0.05). HRECs treated with BMP4 showed a marked increase in phospho-smad 1/5/9 (p = 0.039) and phospho-p38 (p = 0.013). Immunofluorescence of Zo-1 showed that BMP4-treated cells exhibited significant barrier disruption. ECIS also showed a marked decrease in TER of HRECs by BMP4 treatment compared to vehicle-treated HRECs (p < 0.001). Noggin, LDN193189, LDN212854, and inhibitors of p38 and VEGFR2 significantly mitigated the effects of BMP4 on the TER of HRECs. Our finding provides important insights regarding the role of BMP4 as a potential player in retinal endothelial cell dysfunction in diabetic retinopathy and could be a novel target to preserve the blood–retinal barrier during diabetes.
Numerical Modeling and Analysis of Strengthened Steel–Concrete Composite Beams in Sagging and Hogging Moment Regions
Authors: El-Zohairy Ayman , Mustafa Suzan , Shaaban Hesham , Salim Hani , Allawi Abbas A.
Published: April 2023

Strengthening of composite beams is highly needed to upgrade the capacities of existing beams. The strengthening methods can be classified as active or passive techniques. Therefore, the main purpose of this study is to provide detailed FE simulations for strengthened and unstrengthened steel–concrete composite beams at the sagging and hogging moment regions with and without profiled steel sheeting. The developed models were verified against experimental results from the literature. The verified models were used to present comparisons between the effect of using external post-tensioning and CFRP laminates as strengthening techniques. Applying external post-tensioning at the sagging moment regions is more effective because of the exhibited larger eccentricity. In the form of an initial camber and compressive stresses in the bottom flange prior to loading, this reasonable eccentricity induces reverse loading on the reinforced beams, reducing the net tensile stress induced during loading. Using CFRP laminates on the concrete slab for continuous composite beams is more effective in enhancing the beam capacity in comparison with using the external post-tension. However, reductions in the beam ductility were obtained.
Corrosion Evolution of Nickel Aluminum Bronze in Clean and Sulfide-Polluted Solutions
Authors: Yang Liu , Wei Yinghua
Published: April 2023

Nickel aluminum bronze (NAB) alloys are reported to suffer accelerated local corrosion in sulfide-polluted seawater. In this work, the real-time in situ scanning vibrating electrode technique (SVET) was employed to monitor the evolution of the corrosion product film of a typical NAB alloy immersed in the clean and sulfide-polluted 3.5% NaCl solutions. In the sulfide-free condition, the corrosion current peak surged at the individual point of the NAB surface and receded to calm in 2 h. In the presence of the sulfide, however, multiple active points on the measured metal surface released high corrosion current for a long time, indicating that intense corrosion had occurred. The corrosion mass loss was more than four times the former. Global electrochemical techniques, scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) were adopted to perform a comprehensive analysis of the composition of the corrosion product films. The results show that a dense layer of aluminum and cuprous oxide forms on the NAB surface in the sulfide-free solution, while a loose mixture of cuprous sulfide and cuprous oxide is detected in the sulfide-contaminated solution. This finding is believed to account for the observed distinction between the corrosion behavior of NAB in the two solutions.
Trimodality Treatment of Superior Sulcus Non-Small Cell Lung Cancer: An Institutional Series of 47 Consecutive Patients
Authors: Rzyman Witold , Łazar-Poniatowska Małgorzata , Dziedzic Robert , Marjański Tomasz , Łapiński Mariusz , Dziadziuszko Rafał
Published: April 2023

Objectives: Treatment of superior sulcus tumors (SST) using concurrent chemoradiation followed by surgery is a current standard. However, due to the rarity of this entity, clinical experience in its treatment remains scarce. Here, we present the results of a large consecutive series of patients treated with concurrent chemoradiation followed by surgery at a single academic institution. Materials and Methods: The study group included 48 patients with pathologically confirmed SST. The treatment schedule consisted of preoperative 6-MV photon-beam radiotherapy (45–66 Gy delivered in 25–33 fractions over 5–6.5 weeks) and concurrent two cycles of platinum-based chemotherapy. Five weeks after completion of chemoradiation, pulmonary and chest wall resection was performed. Results: From 2006 to 2018, 47 of 48 consecutive patients meeting protocol criteria underwent two cycles of cisplatin-based chemotherapy and concurrent radiotherapy (45–66 Gy) followed by pulmonary resection. One patient did not undergo surgery due to brain metastases that occurred during induction therapy. The median follow-up was 64.7 months. Chemoradiation was well tolerated, with no toxicity-related deaths. Twenty-one patients (44%) developed grade 3–4 side effects, of which the most common was neutropenia (17 patients; 35.4%). Seventeen patients (36.2%) had postoperative complications, and 90-day mortality was 2.1%. Three- and five-year overall survival (OS) were 43.6% and 33.5%, respectively, and three- and five-year recurrence-free survival were 42.1% and 32.4%, respectively. Thirteen (27.7%) and 22 (46.8%) patients had a complete and major pathological response, respectively. Five-year OS in patients with complete tumor regression was 52.7% (95% CI 29.4–94.5). Predictive factors of long-term survival included age below 70 years, complete resection, pathological stage, and response to induction treatment. Conclusions: Chemoradiation followed by surgery is a relatively safe method with satisfactory outcomes.
Lichen-Associated Oribatid Mites in the Taiga Zone of Northeast European Russia: Taxonomical Composition and Geographical Distribution of Species
Authors: Melekhina Elena N.
Published: April 2023

We examined 35 species of ground and epiphytic lichens, including fruticose, foliose, and crustose lichen, as habitats of oribatid mites. Observations were carried out in the taiga forests of northeast European Russia, and 87 oribatid species from 38 families were found. The Crotoniidae, Carabodidae, Oppiidae, and Suctobelbidae are the most numerous families in ground lichens and the Oribatulidae are in the epiphytes. The families Micreremidae and Licneremaeidae were only noted in epiphytes. A complex of species characteristic of epiphytic lichens as habitats of oribatid mites have been identified, these are Carabodes labyrinthicus, Oribatula (Z.) propinqua, Phauloppia nemoralis, Micreremus brevipes, Licneremaeus licnophorus, Furcoppia (Mexicoppia) dentata, Cymbaeremaeus cymba. Only in epiphytes, rarely, the species were also Jacotella frondeus, Ameronothrus oblongus, Mycobates (Calyptozetes) tridactylus, and Liebstadia humerata. Characteristic for ground lichens are species Trhypochthonius cladonicolus, Carabodes marginatus, Carabodes subarcticus. Often found in both ground and epiphytic lichens are species Eueremaeus oblongus s. str., E. oblongus silvestris, Ceratoppia quadridentata, Adoristes ovatus poppei, Graptoppia (Apograptoppia) foveolata, Suctobelbella acidens duplex, Tectocepheus velatus, Trichoribates berlesei, Chamobates pusillus, Diapterobates oblongus, Oribatula tibialis, Oribatula (Z.) exilis, Scheloribates laevigatus, Neoribates aurantiacus, Pergalumna nervosa. In epiphytic lichens, we observed species that are rare in the North (Oribatula (Z.) frisiae, O. (Z.) propinqua, P. nemoralis, L. licnophorus, F. (M.) dentata, et al.), with some noted in the taiga zone for the first time (J. frondeus).
Global Diversity, Distribution, and Genetic Studies of Stable Flies (Stomoxys sp.)
Authors: Duvallet Gérard , Hogsette Jerome A.
Published: April 2023

In the subfamily Stomoxyinae there are currently 18 recognized Stomoxys species, plus two subspecies. Most Stomoxys knowledge was gained through studies with S. calcitrans, a cosmopolitan species, economic pest, and vector. Other Stomoxys spp. are known only from a few trapped adult specimens. Herein, the Stomoxys spp. have been grouped by their ecological diversity, global distribution, and phylogeny and phylogeography. Seven species are dependent to some degree on humans and their activities, particularly animal production. Eleven species are dependent on wildlife to some degree for their development, and little is known about their biology in many cases. Global distributions include one cosmopolitan species (S. calcitrans), twelve species found only in Africa, four species only in Asia, and one species (S. sitiens) in Africa and Asia. Most genetic studies on Stomoxys calcitrans showed little variation in North America, possibly due to the adults’ long range flight capability. Phylogeographic analysis of S. calcitrans showed a differentiation between Oriental populations (first lineage) and populations from Afrotropical, Palearctic, Nearctic, Neotropical and Oceanian regions (second lineage). Genetic studies were followed by sequencing of the Stomoxys calcitrans genome and phylogenetic studies of the Stomoxys genus using 10 of the known species. Phylogenetic relationships were established.
Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case–Control Study according to Current Diagnostic Criteria
Authors: Rodríguez-Fonseca Lucía , Llorente-Pendás Santiago , García-Pola María
Published: April 2023

Objective: To estimate the prevalence of prediabetes and diabetes in patients with oral lichen planus (OLP). Methods: Prospective cohort, including consecutive patients diagnosed clinically and histologically with OLP from 2018 to 2022. Patients and controls were matched by age and gender. Fasting plasma glucose value collection from all patients. Multivariate regression analysis evaluated the relationship between prediabetes and diabetes variables according to current diagnostic criteria. Results: The sample comprised 275 patients (207 women; 75.3%), mean age 59.60 ± 12.18 years for both groups. Prediabetes was diagnosed according to the American Diabetes Association (ADA, 100–125 mg/dL), in 21.45% of OLP patients (59/275) and 14.55% (40/275) of control patients (p = 0.035). Patients with the atrophic-erosive form exhibited stronger association with taking oral antidiabetics (p = 0.011). Multivariate analysis showed that being over >60 years and having a cutaneous location was associated with ≥3 sites (OR 1.81 and OR 2.43). ADA prediabetes and oral antidiabetics drugs increased the probability of OLP (OR 1.60 (1.04–2.51), p = 0.03 and OR 2.20 (1.18–4.69), p = 0.017) after adjustment for sex and age. Conclusions: Because glycemia 100–125 mg/dL was associated with OLP, testing serum fasting plasma glucose seems reasonable in order to prevent development of diabetes and deal with possible complications until new studies are complete.
Deep Classification with Linearity-Enhanced Logits to Softmax Function
Authors: Shao Hao , Wang Shunfang
Published: April 2023

Recently, there has been a rapid increase in deep classification tasks, such as image recognition and target detection. As one of the most crucial components in Convolutional Neural Network (CNN) architectures, softmax arguably encourages CNN to achieve better performance in image recognition. Under this scheme, we present a conceptually intuitive learning objection function: Orthogonal-Softmax. The primary property of the loss function is to use a linear approximation model that is designed by Gram–Schmidt orthogonalization. Firstly, compared with the traditional softmax and Taylor-Softmax, Orthogonal-Softmax has a stronger relationship through orthogonal polynomials expansion. Secondly, a new loss function is advanced to acquire highly discriminative features for classification tasks. At last, we present a linear softmax loss to further promote the intra-class compactness and inter-class discrepancy simultaneously. The results of the widespread experimental discussion on four benchmark datasets manifest the validity of the presented method. Besides, we want to explore the non-ground truth samples in the future.
Analysis and Explanation of Resonant Phenomena Involving EHV Transformers during Power System Restoration Tests
Authors: Benato Roberto , Dambone Sessa Sebastian , Giannuzzi Giorgio Maria , Pisani Cosimo , Poli Michele , Sanniti Francesco
Published: April 2023

This paper deals with the simulation and the experimental confirmation of electromagnetic events that could interfere with the successful formation of the restoration path during the power system restoration procedure. The studied phenomena are more relevant for bulk power systems characterized by a low short circuit power as the restoration backbone. In particular, two case studies have been simulated and analyzed: one related to a transformer energization during the formation of the restoration path, and the other one occurred after the de-energization of some transmission lines and one autotransformer belonging to the restoration path. From the simulation results, it emerged that such events are related to the resonant effects between the supplying transformer and the restored network. Such resonances could have negative effects on the restoration if they are not effectively managed. In order to evaluate the impact of such phenomena in real networks, the measurement recordings of on-field tests were compared with the simulation results. It is worth noting that the performed analyses require the knowledge of several parameters that were not always available in practice. Hence, the exact magnitude of the described resonant phenomena was not easy to foresee for the restoration of real networks. The performed comparison confirms the preliminary simulation results and highlights that detailed electromagnetic models are particularly important to support the power system restoration management, in particular the planning of recovery procedures.
A Review of Nanocrystalline Film Thermoelectrics on Lead Chalcogenide Semiconductors: Progress and Application
Authors: Dashevsky Zinovi , Mamykin Sergii , Dzundza Bohdan , Auslender Mark , Shneck Roni Z.
Published: April 2023

Submicron-structured films of thermoelectric materials, exhibiting an improved thermoelectric figure of merit, are reviewed, including methods of fabrication and characterization. The review emphasizes the beneficial role of the grain boundaries in polycrystalline films. The enhanced Seebeck coefficient of lead chalcogenide films is attributed to a potential relief that is built along the grain boundaries. It scatters charge carriers with low energy and does not affect carriers with higher energy. The model that accounts for the thermoelectric properties of the films is described and assessed experimentally. The application of a flexible thermoelectric device (module) based on the nanocrystalline film thermoelectric semiconductors as high sensitivity radiation detectors is suggested.
Technical Analysis of the Large Capacity Grid-Connected Floating Photovoltaic System on the Hydropower Reservoir
Authors: Nguyen Nghia-Hieu , Le Bao-Chi , Nguyen Le-Ngoc , Bui Thanh-Trung
Published: April 2023

Among the energy targets of the Vietnamese government, solar energy is expected to become the main source of renewable energy in the future. Solar energy is moving forward, with Vietnam outstripping Thailand and becoming the country that installed the largest capacity of solar power generation in Southeast Asia, reaching 16,362 MW in new installations in December 2021. In this study, we have experimentally analyzed and designed a capacity of 47.5 MW grid-connected photovoltaic plant mounted on the floatation system at Da Mi hydropower reservoir in Binh Thuan province. This was selected to be utilized as the first effort to develop the first large-capacity floating solar power plant on a hydroelectric reservoir in Vietnam. A detailed examination of the electrical analysis, including DC to DC converters, AC inverters to the transmission network, and PV module connectivity configurations, are in scope. The present research has the potential to make a contribution to the design of the DC electrical part, the AC electrical part, and the layout PV modules—Inverter—Floatation system—Floating bridge of FPV plants which are less described in the former articles. The performance of the plant after the first 2 years of operation has confirmed that it has met the expectations and exceeded the investor’s target, with the power output of the first 2 years being higher than the design by 102.58% to 105.59% and no serious damage has occurred to the equipment from 1 June 2019 to 31 August 2021.
Sustainability of Biorefineries: Challenges and Perspectives
Authors: Solarte-Toro Juan Camilo , Cardona Alzate Carlos Ariel
Published: April 2023

Biorefineries have been defined as complex systems where biomass is integrally processed to obtain value-added products and energy vectors, involving recent research advances, technological trends, and sustainable practices. These facilities are evolving since new pathways and challenges for biomass upgrading appear constantly aimed at increasing process sustainability. Nevertheless, few literature papers summarize how these new trends can improve biorefinery sustainability and boost the transition to renewable resources. This paper reviews several challenges and future perspectives before biorefinery implementation at the industrial level. Challenges related to waste stream valorization, multifeedstock use, biorefinery energy matrix diversification, and new products based on new biomass conversion pathways are reviewed. Thus, this paper provides an overview of the most recent trends and perspectives for improving biorefinery sustainability based on waste stream minimization, integral use of raw materials, and high-value bio-based compound production. A case study is discussed to show how integral biomass upgrading can improve the economic and environmental performance of existing processing facilities. Carbon dioxide capture, storage, and conversion, as well as energy matrix diversification, have been identified as the most important aspects of improving the environmental performance of biorefineries (decarbonization). Moreover, multifeedstock biorefineries are profiled as promising options for upgrading several biomass sources in small-scale and modular systems to produce value-added products for boosting rural bioeconomies. Finally, new ways to produce more bio-based products must be proposed to replace existing oil-based ones.
Experimental Study of a PowerCore Filter Bed Operating in a Two-Stage System for Cleaning the Inlet Air of Internal Combustion Engines
Authors: Dziubak Tadeusz
Published: April 2023

Small dust grains cause a higher intensity of increase in the flow resistance of the fibrous filter bed, which, due to the established value of the permissible resistance, results in a shorter period of operation of the air filter and the vehicle. At the same time, the mass of dust per unit of filtration area takes on smaller values. Such a phenomenon occurs in the two-stage “multicyclone-baffle filter” engine inlet air filtration system. The main objective of this study was to experimentally determine the mass of dust retained per unit of filtration area (dust absorption coefficient km) of the PowerCore filter bed operating under two-stage filtration conditions, which cannot be found in the available literature. The original methodology and conditions for determining the dust absorption coefficient km of a PowerCore filter bed operating under two-stage filtration conditions are presented. Tests were carried out on the characteristics of filtration efficiency and accuracy, as well as on the flow resistance of a filtration unit consisting of a single cyclone and a PowerCore test filter with an appropriately selected surface area of filter material. During the tests, conditions corresponding to the actual conditions of vehicle use and air filter operation were maintained, including filtration speed and the dust concentration in the air. The experimentally determined dust absorption coefficient of the PowerCore research filters operating in a two-stage filtration system took on values in the range of km = 199–219 g/m2. The dust absorption coefficient km of the PowerCore research filter operating under single-stage filtration conditions reached a value of km = 434 g/m2, which is twice as high. Prediction of the mileage of a car equipped with a single-stage and two-stage “multi-cyclone-partition” filtration system was carried out, showing the usefulness of the experimentally determined dust absorption coefficients km.
A Comprehensive Study on DES Pretreatment Application to Microalgae for Enhanced Lipid Recovery Suitable for Biodiesel Production: Combined Experimental and Theoretical Investigations
Authors: Matchim Kamdem Michele , Tamafo Fouegue Aymard , Lai Nanjun
Published: April 2023

Cell wall disturbance is an important step in the downstream process of improving the efficiency of lipid extraction from microalgae. Surfactants have been proven to be efficient alternatives to organic solvents in the extraction process. In this study, an effective approach involving deep eutectic solvent (DES) (choline chloride and carboxylic acids) treatment supplemented with surfactants has been developed to disrupt the cell walls of microalgae and increase the extraction of lipids suitable for biodiesel production. A combination of polar and non-polar solvents (ethyl acetate and n-butanol) was used for the lipid extraction process. Microalgae biomass pretreated with choline chloride malonic acid supplemented with the surfactant hexadecyl trimethylammonium chloride (HTAC) showed the best results, improving lipid extraction by 12.365%. Further elucidation of the detailed mechanism behind the cell disruption of the microalga wall by DES was achieved using density functional theory (DFT) methods. The DFT calculations revealed that hydrogen bonds between the chloride ion of the DES and hydrogen bond donor (HBD) molecules are key factors dominating the destruction of the cell wall structure of Chlorella pyrenoidosa. The optimization of lipid extraction was performed through a single-factor experiment, which included the effects of different variables (time, temperature, dosage of surfactant, and ratio of n-butanol to ethyl acetate). An extraction period of 60 min at 80 °C with a surfactant concentration of 0.5% at a 1:2 ratio of n-butanol to ethyl acetate was found to produce the maximum lipid yield (16.97%). Transesterification reactions were used to obtain fatty acid methyl esters from the optimized extracted lipids. Thus, it was determined that C16:0 (20.04%), C18:2 (29.95%), and C18:3 (21.21%) were the most prevalent fatty acids. The potential for producing biodiesel from C. pyrenoidosa was validated by the high yields of C18 fatty acid methyl esters, and the properties of biodiesel are within the European and US standards.
Research on a Modeling and Control Strategy for Interleaved Boost Converters with Coupled Inductors
Authors: Dai Zhuangzhi , Liu Jilong , Li Kefeng , Mai Zhiqin , Xue Guijing
Published: April 2023

Interleaved DC–DC converters have significant advantages in improving the capability of power converters, and coupling the filtering inductor of the converter could further increase the power density. However, existing modeling and controller designs are complex and require multiple sensors to be involved in the control, which is not conducive to engineering implementation and reducing production costs. In view of this problem, taking a two-phase interleaved boost converter with a coupled inductor as an example, the small-signal models of the converter are derived for the resistive load and constant voltage source load using the state averaging method. The total inductor current is engaged in the control as a feedback signal, avoiding the coupling effect of the inductor on increasing the complexity of the controller. Based on this, a double closed-loop controller is designed, and a prototype of the two-phase interleaved boost converter with coupled inductor is built. Only one current sensor and one voltage sensor are required to participate in the control. The effectiveness of the analysis and design in this paper are verified by experiments.
A Multi-Country Study Assessing the Mechanisms of Natural Elements and Sociodemographics behind the Impact of Forest Bathing on Well-Being
Authors: Subirana-Malaret Montse , Miró Alexandre , Camacho Aracely , Gesse Alex , McEwan Kirsten
Published: April 2023

Interventions such as forest bathing (slow, mindful nature walks) have been shown to increase our connection to nature and be an effective intervention for improving health and well-being. However, there is variation in the activities delivered during forest bathing and the guidance given. Few researchers have evaluated which activities, elements of nature, and senses are responsible for improvements in well-being. The current evaluation addresses this gap and also monitors the emotional state and nature connection following guided forest bathing walks. Participants (N = 1142) across 35 countries completed post-walk evaluation surveys online. Results suggest that well-being and nature connection were rated very highly following forest bathing activities. Experiencing happy feelings and trusting emotions were especially highly rated. The natural elements perceived as contributing the most to well-being were sound-related elements. In terms of sociodemographics, women had higher well-being and nature connection ratings than men; ratings were higher in specialised nature resort areas, with little difference between natural and urban park areas; higher scores were seen in the southern hemisphere and during hot or long-day seasons. This has implications for forest bathing, forest therapy, and nature-based training organisations and their guides who want to improve their method of intervention delivery, maximise well-being, and enhance nature connection.
Efficiency Evaluation and the Impact Factors of Sustainable Forestry Development in China: Adoption of Super-Efficiency Data Envelopment Analysis and Malmquist Index Methods
Authors: Li Mingxing , Wang Xinxing , Agyeman Fredrick Oteng , Gao Ya , Sarfraz Muddassar
Published: April 2023

Forestry is the underpinning of economic and environmental civilization for sustainable economic development. Forestry benefits ecosystems and local dwellings; thus, transforming and advancing forest products in a civilized society is critical to building a progressive community. This research aims to analyze the merits of forest products based on static, dynamic, and scale efficiency. It employed the super-efficient data envelopment analysis—Charnes, Cooper and Rhodes, and Malmquist index methods with an enhanced robustness check by applying the Stochastic Frontier Analysis. The results show that, first, from the perspective of static efficiency, the forestry industry’s operating performance is maintained at a relatively high level, with a minimal fluctuation range; however, the scale efficiency is observed at a deficient level. Limited by the scale efficiency results, the aggregate comprehensive technical efficiency was at a low standard. The average total factor productivity of dynamic efficiency for each company reached 1.029, indicating that the resource allocation of listed companies is relatively reasonable, operating efficiency is on the rise, and technical level changes are a substantial source of total factor productivity growth. Furthermore, the super efficiency DEA findings indicated that 11 of the most high-performance companies attained an efficiency value above criterion value one after re-ranking. The comprehensive efficiency value of Sun Paper reached 1.438 in 2019, Sophia 1.393, Hexing Packaging 1.383, Fujian Jinsen 1.326, Bunny 1.271, Meike Home Furnishing 1.235, Jingxing Paper 1.222, Zhongshun Jiezou 1.116, Meiying Sen 1.099, Chenming Paper 1.064, Da Ya Dekor 1.015. Second, the comprehensive efficiency value of Fujian Jinsen’s company has a more significant impact on the overall average efficiency of the forestry listed companies. After excluding Fujian Jinsen, the average comprehensive efficiency of 2018–2019 indicated an upward trend for the listed companies. This study suggests that policymakers should strengthen the forestry industry development plan and policy implementation regulations to focus on the forward-looking and guiding principles of industrial and technological innovation policies.