bluuebunny/crossref_metadata_2025 huggingface dataset:
SI KALORI: Sistem Pakar Penghitung Jumlah Ideal Kalori Harian Berbasis Mobile
Authors: Suleman Suleman , Faqih Husni , Lesmana Hendra , Utami Bernadette Cahya Putri
Published: November 2024

Gaya hidup masyarakat saat ini mengalami perkembangan yang cukup pesat, dengan banyaknya pilihan makanan cepat saji menambah daftar makanan yang memiliki resiko tinggi terhadap kualitas kesehatan manusia jika tidak dibarengi dengan pola hidup yang sehat, baik dan benar. Tidak tertatanya pola makan dan tidak seimbangnya asupan kalori dalam tubuh menjadi paling umum dari penyakit-penyakit yang marak seperti Obesitas, Diabetes, dan Penyakit Jantung. Kalori adalah salah satu nilai terpenting untuk menjaga berat badan seimbang. Untuk itu, tujuan penelitian ini adalah untuk mengetahui cara menurunkan berat badan yang baik dan benar, mengetahui cara menghitung jumlah kalori yang dibutuhkan untuk menurunkan berat badan, dan membantu orang yang kesulitan menurunkan berat badan. Perancangan sistem pakar ini merupakan solusi yang bisa dipilih bagi masyarakat sebagai upaya untuk menyeimbangkan jumlah kebutuhan asupan kalori dapat diatur secara lebih maksimal dan efektif. Serta, membantu mereka yang memiliki berat badan berlebih atau penyakit yang disebabkan oleh pola makan yang tidak seimbang untuk lebih sadar akan langkah-langkah apa yang harus diambil untuk memiliki tubuh yang sehat dengan kalori yang sesuai dengan tubuh mereka sendiri. Sistem pakar ini akan memvalidasi kebutuhan pengguna untuk mulai bekerja pada penurunan berat badan. Dari hasil pengujian, Sistem Pakar dapat ini dapat mengatasi masalah dalam menjalankan program diet yang tepat dengan menyesuaikan pola makan dengan kalori yang dibutuhkan oleh tubuh pada manusia. Kata Kunci : Sistem Pakar, Kesehatan, Penghitung Kalori, Android
Penentuan Siswa Berprestasi Pada SMP PGRI Kalimulya Menggunakan Metode Weighted Product
Authors: Kholifah Desiana Nur , Komarudin Rachman , Putri Rismawati
Published: November 2024

Pada umumnya sekolah merupakan tempat untuk menuntut ilmu dan proses belajar akademik maupun non akademik. Sekolah akan  melakukan proses penentuan siswa berprestasi setiap semester nya guna untuk meninjau hasil belajar dari setiap siswa. Sebagian besar sekolah termasuk SMP PGRI Kalimulya ini masih menggunakan sistem manual untuk menentukan siswa berprestasi, tetapi dengan cara manual tersebut sangat memakan waktu karena banyaknya jumlah data siswa yang dikumpulkan. Untuk mengefisienkan waktu dalam proses penentuan siswa berprestasi dan mengurangi terjadinya kesalahan dalam menentukan siswa yang berprestasi di sekolah maka dibuatkan perhitungan secara komputerisasi dengan membangun sebuah program sederhana menggunakan metode Weighted Product. Metode weighted product adalah suatu pendekatan untuk mengambil keputusan dengan mengalikan nilai atribut dengan bobot atributnya setelah setiap atribut ditingkatkan (dipangkatkan) terlebih dahulu sesuai dengan bobotnya yang bersangkutan. Faktor dan kriteria yang terlibat dalam penentuan siswa berprestasi sebagai komponen penilaiannya, yakni kriteria pengetahuan, sikap atau perilaku, kehadiran, dan kegiatan ekstrakurikuler. Dengan sampel siswa sebanyak 42 siswa di SMP PGRI Kalimulya ini didapatkan hasil terbesar telah diketahui Bagas Rizkian Pratama menduduki peringkat 1 dengan nilai vektor 0.0338, Muhammad Aryan  menduduki peringkat 2 dengan nilai vektor 0.0327 dan Achmad Egie Maulana menduduki peringkat 3 dengan nilai vektor 0.0317.
Sistem Informasi Persediaan Barang Berbasis Web Pada PT. Arina Multikarya Jakarta
Authors: Wijaya Leo Perkasa , Rosyida Susy
Published: November 2024

Perkembangan zaman saat ini telah memudahkan berbagai aspek kehidupan melalui sistem informasi. Hal ini termasuk kemampuan untuk lebih mudah dan akurat memantau stok gudang. Pada PT. Arina Multikarya Jakarta, barang masuk dan keluar di gudang masih menggunakan metode manual, tujuan utama dari sistem informasi persediaan barang ini untuk pemantauan kinerja dan analisis data yang terkait dengan operasional gudang. Melalui sistem ini, dapat mengakses laporan-laporan yang dihasilkan oleh sistem untuk mengevaluasi kinerja gudang, memahami tren, dan mengidentifikasi area yang memerlukan perbaikan. Analisis ini akan membantu dalam pengambilan keputusan yang lebih baik dalam pengelolaan gudang dan dalam meningkatkan efisiensi operasionalnya. Sistem informasi persediaan barang juga memungkinkan pengelolaan inventaris atau persediaan barang di gudang menjadi lebih efisien. Dapat dengan mudah melihat stok barang yang tersedia, melakukan pembaruan, mengatur pemesanan, dan memantau pergerakan barang secara real-time. Hal ini membantu mengurangi risiko kekurangan atau kelebihan stok barang. Selain itu, sistem ini dapat melakukan pelacakan yang akurat terhadap pergerakan barang di dalam gudang. Dengan sistem pencatatan yang terintegrasi, dapat melacak asal-usul, jumlah, dan lokasi setiap barang yang masuk atau keluar dari gudang. Dapat meningkatkan visibilitas terhadap aliran barang dan memudahkan pengendalian inventaris. Dalam pembuatan sistem informasi persediaan barang berbasis website, metode pengembangan sistem yang digunakan adalah model spiral, yang terdiri dari tahapan komunikasi dengan pelanggan, perencanaan, analisis risiko, perekayasaan, konstruksi, peluncuran, dan evaluasi pelanggan. Penggunaan sistem informasi telah mempermudah PT. Arina Multikarya dalam melihat data stok secara real-time dalam operasional gudangnya.               Kata kunci: Persediaan Barang, Sistem Informasi
Violência doméstica e de gênero contra a mulher:
Authors: Lívia Mattar Silva Oliveira  , Fernando Laércio Alves da Silva
Published: November 2024

O presente artigo é o resultado de pesquisa que objetivou identificar o perfil dos casos de violência doméstica e de gênero contra a mulher e as medidas adotadas no âmbito administrativo e judicial e da atuação do Programa Casa das Mulheres (NIEG-UFV) no município de Viçosa-MG, no período 2007-2020. A pesquisa se pautou pelo método bibliográfico-documental, com coleta de artigos científicos e busca e análise de informações cadastrais junto ao Programa Casa das Mulheres. Ao final, constatou-se a insuficiência das informações para o monitoramento e a efetividade das políticas de enfrentamento à violência contra a mulher, restando claro, ainda que indiciariamente, a sobrecarrega do órgão judiciário local, por um lado, e a necessidade de regularidade no aporte de recursos financeiros para de atividades como as do Programa Casa das Mulheres - essencial para a formação da rede de atendimento a mulheres em situação de violência, com caráter intersetorial e interdisciplinar.
Atitudes e expectativas de futuro na transição carreira-aposentadoria
Authors: Pereira de Souza Andreia , Helena de F. P. França Lucia , Miranda Amorim Silvia
Published: November 2024

A aposentadoria deve ser investigada considerando a sua multidimensionalidade enquanto fenômeno, cujo planejamento sofre desde o início a influência das atitudes e expectativas dos pré-aposentados. Esta pesquisa objetivou analisar as atitudes e expectativas frente ao futuro em um grupo de pré-aposentados de empresa do setor de energia. Foram realizadas 24 entrevistas individuais que seguiram um roteiro pré-estruturado e analisadas por meio do software Iramuteq, utilizando a Classificação Hierárquica Descendente. O corpus denominado Atitudes e Expectativas de Futuro obteve aproveitamento de 75,50% dos textos analisados e sugeridas seis Classes. Nas entrevistas, a perda dos relacionamentos foi evidenciada e a transição gera reflexões e questionamentos, sendo considerada uma nova fase, com graus variados de relevância para cada trabalhador. A pesquisa contribuiu para compreensão das atitudes e expectativas dos trabalhadores mais velhos.
Prerequisites for the transformation of the element of national consciousness in the Kazakh worldview at the beginning of the XXI century
Authors:   L.N. Gumilyov Eurasian National University, Dzhukeeva B.A. , Imanzhusip R.N. ,   L.N. Gumilyov Eurasian National University, . Kashaganova T.U ,   Temirbek Zhurgenov Kazakh National Academy of Arts
Published: November 2024

In the articlethe prerequisites for the transformation of national consciousness in the Kazakh worldview at the beginning of the 21st century were deeply analyzed, including the main external and internal influencing factors in the stages of the formation of the national consciousness own development path. We hope that the historical foundations of the formation of a new national consciousness of the citizens of Kazakhstan, the modernization of the national consciousness in the context of the globalization process, and the establishment of new principles of national identity will not be ignored and will arouse the interest of scientists dealing with these issues. In the conditions of Kazakhstan independence, social and humanitarian sciences underwent a certain transformation, their role in the modernization of public consciousness is undoubtedly important. Among the relevant historical topics, the performance should highlight innovative issues that were unthinka-ble recently. In this regard, the relevance of the conceptual direction associated with field civilization is un-deniable. The scientific article defines the problem of national cognition, as well as the increasing complexity and dynamics of the social process, which creates the need for their scientific and philosophical reflection.
A invisibilidade da libras no cenário de saúde brasileira
Authors: Campos Israel , Nery Ana Beatriz de Almeida , Lôbo Anna Carolina Paiva , Lemos Isabella Maria Duarte , Seixas Milla Crist Mato Grosso
Published: November 2024

Este artigo evidencia como a Língua Brasileiras de Sinais (LIBRAS) é negligenciada no Brasil, com destaque principalmente à conjuntura de saúde atual, visto que grande parte da população brasileira não ouvinte apresenta dificuldades para estabelecer uma comunicação eficiente com profissionais, como médicos, enfermeiros e psicólogos ouvintes, porquanto esses não dominam a comunicação através da LIBRAS. Assim, foi feita uma pesquisa científica, a partir de uma revisão narrativa de literatura, buscando uma reflexão crítica sobre a comunicação entre surdos e ouvintes, sobre o histórico da cultura surda, sobre as razões que culminam no atendimento ineficaz dos indivíduos com surdez e sobre os possíveis caminhos para solucionar os déficits do sistema de saúde para com a população não ouvinte
Prospects for the application of methanation technologies for the production of synthetic renewable methane in Ukraine
Authors: Suprun T.
Published: November 2024

It is known that one of the most important and urgent problems of modern world energy has become the search and development of renewable energy sources as alternatives to traditional fossil fuels.

Methanation, that is, the reaction of the transformation of carbon dioxide and hydrogen to produce synthetic renewable methane, is one of the areas of search and development of alternative energy sources as a substitute for scarce natural gas.

The object of this study is synthetic renewable methane, as well as features of methanation technologies for its production.

The purpose of the work is to review global experience in the development of methanation technologies for the production of synthetic renewable methane and to identify promising ways to introduce these technologies in Ukraine.

Research methods include the study and analysis of literature and other data, in particular the results of the implementation of methanation projects.

As studies have shown, methanation technologies with only renewable components are especially interesting for the conditions of Ukraine. It is these technologies that are analyzed in the article.

The paper examines the technological possibilities of using catalytic and biological methanation methods for the effective use of renewable solar and wind electricity to generate hydrogen by electrolysis of water, as well as carbon dioxide of organic origin for the production of synthetic renewable methane.

The technology of biological methanation is considered in most detail as a promising direction for introducing methanation technologies in Ukraine for the production of synthetic renewable methane. Aspects related to modern technologies, such as in situ, ex situ, are analyzed. The features of the concept of underground methanation, which is one of the areas of biological methanation, are shown.

The work examines various designs of reactors for catalytic and biological methanation, and notes their advantages and disadvantages.

Some measures that will make industrial production of synthetic renewable methane based on methanation technology profitable in the future are indicated.
A case of oxaliplatin-induced immune thrombocytopenia followed by complete remission of metastatic colon cancer
Authors: Shibata Masahiko
Published: November 2024

An 87-year-old male underwent laparoscopic left hemicolectomy for adenocarcinoma of the descending colon in December 2021. Lung metastasis was found in the left upper lobe 6 months postoperatively, and it increased in size after 9 months from the surgery. S-1 plus oxaliplatin (SOX) was started in October 2022. The lung metastasis was shrinking within 23 cycles of SOX therapy. The 24th cycle of SOX (only oxaliplatin) was administrated in April 2024, the catheter of venous infusion line of right forearm was removed after finishing the infusion, however bleeding did not stop. The platelet count was rapidly dropped into 2,000/μl from 131,000/μl (pretreatment) within 7 hours and hemoglobin levels decreased from 10.9 to 8.9 in the same period, furthermore, dropped into 6.2 g/dl in next 24 hours. PA-IgG was significantly high (204.0 ng/107 cells; normal < 30.2). Transfusion of platelet, red blood cell concentrate, steroid pulse therapy, antibiotic treatment with multiple agents and non-invasive positive pressure ventilation (NPPV with oxygen were performed. As a result, the patient’s platelet count was increased and his DIC score was decreased to 3 points (normal range) in April 2024. The patient’s general condition gradually improved, and he was discharged from hospital on the 35th day of hospitalization. CT scan after discharge showed complete remission of the lung metastasis. Possible mechanisms and approach to treatment are discussed.
MASHUP FORMUNUN KLASİK TÜRK VE BATI MÜZİĞİNDE KULLANIMI
Authors: Okcu Semih , Tolan Cansu
Published: November 2024

Bu araştırma, farklı şarkıların ve müzik parçalarının birleştirildiği yeni bir müzik türü olan “Mashup müzik türünün” Klasik Türk ve Batı müziğinde, “Mashabilitiy Veri Hazırlığının Modellenmesi, Metodolojisi ve Mashup Veri Tabanının oluşturulması” doğrultusunda kullanılması açısından örnek teşkil etmektedir. Araştırma betimsel araştırmalardan genel tarama modeli ile yürütülmüştür. Konuyla ilgili olarak gerekli literatür araştırmaları taranmış ve konular ile başlıklandırarak sunulmuştur. Araştırmada toplanan verilerin kitap, bildiri, makale ve web kaynaklarından yararlanılarak Mashup müzik türü ile ilgili bilgiler ve bu bilgiler ışığında konu ile ilgili aydınlatıcı görüşlerin toplanması sağlanmıştır. Bu çalışmada yeni bir Mashup müzik türü oluşturmak için “Hasan Özçivi”nin bestelediği “Nihavend Sirto”adlı eseri ve Johannes Brahms’ın bestelediği “Hungarian Dance No.5” adlı eserleri ele alınarak ritmik yapıları ve ton yapıları uyumlu olacak şekilde enstrüman partisyonları kayıt alınarak akışın sağlandığı müzik türü (mashup) gösterilmeye çalışılmıştır. Bu örnekleme yolu ile de Mashup müziği, Klasik müziklerde olduğu gibi halk müziği ve değişik müzik formları ile harmanlanarak çeşitlenebileceği ve bu türlerin daha fazla ilgi çekmesine yardımcı olabileceği öngörülmektedir.
Common sense as identity health: toward a reflection on the russian-Ukrainian war
Authors:   University of Munster, Mudrakov Vitalii , Hapchenko Olena ,   Khmelnytsky National University, Kozachenko Svitlana
Published: November 2024

In the broadest sense, the purpose of the article can be defined as outlining the relationship between common sense and national identity in the context of the russian-Ukrainian war. The subject specificity emphasizes the problem of forming and nurturing the mental field of modern russians as a painful state of their identity: common sense as a marker of identity health. The article structurally reflects and develops the idea of the study of common sense as a phenomenon that affects the formation of identity, which was first presented in the study "Identity Security: from the Problems of Sectoral Definition to the Peculiarities of Didactic Definition" (ISBN: 978-617-7600-61-8). The methodological basis is the phenomenological guideline for direct study of the situation, which in this study is specified as a systematic analysis of experience that conveys value and political priorities. The authors propose three contexts of analysis – semantic, practical philosophy, and philosophy of knowledge – according to which they establish criteria for determining the state of health of identity. Concluding that it is important to constantly analyze the mental field of modern russians, the authors point out that this is a matter for a special research complex of human security. The conclusion is the thesis that the modern russian identity is "sick" with a worldview disease, and that its "treatment" must take place through the shared responsibility of all russians, through their repentance and rethinking. The key provisions of the article were developed in an ongoing discussion and academic dialog between the authors.
Legal entity of the Catholic Church as a participant in Land and Mortgage Register proceedings in Polish law – selected issues
Authors: Broński Włodzimierz , Sławicki Piotr
Published: November 2024

This article evaluates the legal norms related to real estate trading by legal entities of the Catholic Church in the context of land and mortgage register proceedings. First, the issue of the legal entity of the relevant church legal entities is presented. Next, the principles of the representation of church legal entities by the competent authorities is analysed. This is important both for the capacity to undertake a substantive legal action, the subject of which is real estate, and for examining the effectiveness of procedural steps taken in the course of land and mortgage register proceedings. The last part is devoted to real estate trading with the participation of church legal entities in the context of the principles resulting from the regulations of land and mortgage register proceedings. The research leads to the conclusion that for land and mortgage register proceedings, it is of fundamental importance to assess the effectiveness of a legal act in the context of the specific requirements of canon law, examples of which are Canons 1281 § 1 of the Code of Canon Law with regard to acts exceeding the limits and manner of ordinary management, and Canons 1292 § 1–2 of this Code making the validity of alienation dependent on the consent or authorisation of the competent entity. The absence of the consent or authorisation required by the provisions of canon law should lead to dismissal of the application for entry, which can possibly be remedied by a subsequent confirmation of the legal act performed by applying the instruments of civil law, as exemplified by Articles 39 and 63 of the Civil Code. In addition, the implementation of the principle of the autonomy of the Catholic Church is expressed in leaving to the church authority regulation of the appointment of the competent bodies of church legal persons; the land and mortgage register court cannot question the effectiveness of the appointment of these bodies, the assessment of which is left to the Catholic Church and its organisational units.
The Genus Alatyroceras gen. nov. (Ammonoidea: Cardioceratidae, Arctocephalitinae) from the Upper Bathonian (Middle Jurassic) of the Russian Platform
Authors: Mitta V. V.
Published: November 2024

A new genus Alatyroceras is established for the species A. nageli (Mitta) (type species of the genus), A. keuppi (Mitta), A. efimovi (Mitta), and A. infimum (Gulyaev et Kisselev), in Central Russia characterizing the interval correlated with the Upper Bathonian Variabile and Calyx zones of East Greenland. According to the refined data, the Keuppi Zone of the Russian Platform includes (from bottom to top) the efimovi, nageli, and keuppi faunal horizons. The genus Alatyroceras [M] completes the phylogenetic lineage Arcticoceras → Alatyroceras in the subfamily Arctocephalitinae; the name Costacadoceras Rawson is common to all microconchs of the subfamily.
Microstructure of the Valves of the Genus Praeoehlertella Mergl (Family Discinidae) from the Upper Devonian Deposits of Kazakhstan
Authors: Smirnova T. N. , Gatovsky Yu. A. , Zhegallo E. A.
Published: November 2024

The shell microstructure of rarely discovered lingulate genus Praeoehlertella Mergl, 2001 was studied in detail. It was obtained in Famennian stage of Kazakhstan. The peculiarity of the microstructure the secondary granular layer was discovered. The prints of the cells of the inner epithelium of mantle were observed.
Palmatolepis abramovaе sp. nov. – a New Conodont Species from the Makarovo Horizon (Lower Famennian, Upper Devonian), the Western Slope of the South Urals
Authors: Tagarieva R. Ch.
Published: November 2024

New conodont species of Palmatolepis genus – Pa. abramovaе sp. nov. is described from the Makarovo Horizon deposits from 4 sections: Bolshaya Barma, Akkyr, Ryauzyak and Kuk-Karauk. The ontogenetic series and phylogenetic relationships for species are here. Pa. abramovaе sp. nov. is characteristics species for the Upper triangularis Zone.
First Finding of an Ichthyosaur in the Udmurtia (Cis-Ural Region, Russia)
Authors: Bakaev A. S. , Sergeev A. V. , Zverkov N. G.
Published: November 2024

A dorsal vertebra of an ichthyosaur is described from the fluvial deposits of the Kama River (Votkinsk District, Udmurt Republic, Russia). This vertebra belonged to a fairly large ichthyosaur about 5–6 m long, apparently one of the largest ichthyosaurs known from European Russia. The find is redeposited, and it is problematic to establish its exact age: most likely, the vertebra was brought by the Kama River from Jurassic–Cretaceous outcrops located upstream.
Structural studies of ion channels: achievements, problems and perspectives
Authors: Zhorov B. S. , Tikhonov D. B.
Published: November 2024

The superfamily of membrane proteins known as P-loop channels encompasses potassium, sodium, and calcium channels, as well as TRP channels and ionotropic glutamate receptors. An increasing number of crystal and cryo-EM structures are uncovering both general and specific features of these channels. Fundamental folding principles, the arrangement of structural segments, key residues that influence ionic selectivity, gating, and binding sites for toxins and medically relevant ligands have now been firmly established. The advent of AlphaFold2 (AF2) models represents another significant step in computationally predicting protein structures. Comparison of experimental P-loop channel structures with their corresponding AF2 models shows consistent folding patterns in experimentally resolved regions. Despite this remarkable progress, many crucial structural details, particularly important for predicting the outcomes of mutations and designing new medically relevant ligands, remain unresolved. Certain methodological challenges currently hinder the direct assessment of such details. Until the next methodological breakthrough occurs, a promising approach to analyzing ion channel structures in greater depth involves integrating various experimental and theoretical methods.
Structure and function of the proton channel OTOP1
Authors: Sladkov K. D. , Kolesnikov S. S.
Published: November 2024

OTOP1 belongs to the otopetrin family of membrane proteins that form proton channels in cells of diverse types. In mammals, OTOP1 is involved in sour transduction in taste cells and contributes to otoconia formation in the inner ear. From the structural point of view, otopetrins, including OTOP1, represent a quasi-tetramer consisting of four α-barrels. The exact transport pathways mediating proton flux through the OTOP1 channel and gating units modulating its activity are still a matter of debate. This review discusses current data on structural and functional features of OTOP1. Suggested proton transport pathways, regulatory mechanisms, and key amino acid residues determining functionality of the otopetrins are considered. The existing kinetic models of OTOP1 are discussed as well. Based on revealed functional properties, OTOP1 is suggested to operate as a logical XOR element that allows for proton flux only if transmembrane pH gradient exists.
Role of membrane H+ transport and plasmalemma excitability in pattern formation, long-distance transport and photosynthesis of Characean algae
Authors: Bulychev А. A. , Krupenina N. A.
Published: November 2024

Illuminated giant cells of Characeae comprise alternating areas with H+ pump activity and zones with high conductivity for H+/OH–, which create counter-directed H+ flows between the medium and the cytoplasm. In areas where H+ enters the cell, the pH on the surface (pHo) increases to pH 10, while the cytoplasmic pH (pHc) decreases. The lack of the permeant substrate of photosynthesis (CO2) and the acidic pHc shift in the region of external alkaline zones redirect electron transport in chloroplasts from CO2-dependent (assimilatory) pathway to O2 reduction. This electron transport route is associated with an increase in thylakoid membrane ΔpH and an enhanced nonphotochemical quenching (NPQ) of chlorophyll excitations, which underlies strict coordination between nonuniform distributions of pHo and photosynthetic activity in resting cells. When the action potential (AP) is generated, the longitudinal pH profile is temporarily smoothed out, while the heterogeneity of the distribution of NPQ and PSII photochemical activity (YII) sharply increases. The damping of the pHo profile is due to the suppression of the H+ pump and passive H+ conductance under the influence of an almost 100-fold increase in the cytoplasmic of Ca2+ level ([Ca2+]c) during AP. The increase in [Ca2+]c stimulates photoreduction of O2 in chloroplasts under external alkaline zones and, at the same time, arrests the cytoplasmic streaming, which causes the accumulation of excess amounts of H2O2 in the cytoplasm in areas of intense production of this metabolite, with a weak effect on areas of CO2 assimilation. These changes enhance the nonuniform distribution of cell photosynthesis and account for the long-term oscillations of chlorophyll fluorescence Fm' and the quantum efficiency of linear electron flow in microscopic cell areas after the AP generation.
Evolutionary choice between cholesterol and ergosterol
Authors: Sokolov S. S. , Akimov S. A. , Severin F. F.
Published: November 2024

Sterol biosynthesis has evolved early in the history of eukaryotes. In most animals, as well as in primitive fungi, the main sterol is cholesterol. During the process of evolution, fungi acquired the ability to synthesize ergosterol. The pathway of its biosynthesis is more complex than the one of cholesterol biosynthesis. However, the evolutionary choice of most fungi was ergosterol, and the reason for this choice is still debated. In the majority of the works on this issue, the choice of most fungi is associated with the transition to life on land, and, consequently, the danger of cell dehydration. In our review we oppose this point of view. Probably, compared to cholesterol, ergosterol has more pronounced antioxidant properties. Indeed, the presence of three double bonds in the structure of the ergostеrol molecule, as compared to one in cholesterol, relatively increases the likelihood of interaction with reactive oxygen species. Perhaps, the transition to life on land required additional antioxidant protection. Due to the aforementioned structural differences, the molecule of cholesterol is apparently more flexible than that of ergosterol. Experimental data indicate that this feature provides greater membrane flexibility as compared to fungal membranes, as well as a greater ability to compensate for disturbances in the packing of membrane phospholipids. Presumably, for animal cells these qualities turned out to be relatively more important than antioxidant ones, which predetermined their evolutionary choice of sterol.
Mechanisms of lipid-mediated regulation of the pore-forming activity of antimicrobial agents: studies on planar lipid bilayers
Authors: Efimova S. S. , Ostroumova O. S.
Published: November 2024

Planar lipid bilayers are unique tools designed for modeling cell membranes and electrophysiological studies of incorporated ion channels. Such model systems are designed to limit the number of components taking part in the functioning of biological membranes in order to characterize in detail the occurring processes under well-controlled experimental conditions. Planar lipid bilayers make it possible to record single events with a measured current of more than a tenth of a picoampere. The relative simplicity of the method, the ability to observe single molecular events, and the high reproducibility of the results obtained determines the unprecedented effectiveness of using planar lipid bilayers to identify key physical and chemical factors responsible for regulating the functioning of ion channels. This review represents an analysis of literature data concerning the mechanisms of lipid-associated regulation of ion channels formed by various antimicrobial agents. The examination allows us to consider the lipids as molecular chaperones that ensure the formation of pores in target membranes by antimicrobials.
ОСОБЛИВОСТІ ТА РОЛЬ МАРКЕТИНГУ АГРАРНИХ ПІДПРИЄМСТВ В КОНТЕКСТІ ЇХ КОНКУРЕНТНОГО РОЗВИТКУ
Authors: СЕРГІЄНКО Олександр
Published: November 2024

Проведене дослідження визначає важливі аспекти ролі маркетингу в діяльності аграрних підприємств в умовах зростаючої конкуренції. Аграрний маркетинг розглядається як система управління діяльністю аграрних компаній, що забезпечує регулювання ринкових процесів та вивчення аграрного ринку, формує умови для визначення потреб споживачів та можливостей їхнього задоволення в умовах сучасних викликів. Визначено етапи розвитку аграрного маркетингу, починаючи від процесів агроіндустріалізації. Досліджено, що в процесі еволюції змінюється розуміння сільськогосподарського маркетингу, у зв’язку із певними інституційними і технічними обмеженнями аграрної сфери, її обмеженими можливостями для управління комплексом маркетингу. В умовах сучасності маркетинг є провідною концепцією у формуванні взаємозв’язків  між виробниками та споживачами сільськогосподарської продукції. Визначено, що у науковій літературі існують різноманітні трактування маркетингу у аграрній сфері, такі як «маркетинг у сільському господарстві», «агромаркетинг», «маркетинг в агропромисловій сфері». Узагальнено наукові підходи до розуміння дефініції «аграрний маркетинг» та виокремлено: виробничий, функціональний, системний та результативний підходи з конкретизацією дослідників щодо кожного підходу. Обгрунтовано, що аграрний маркетинг в силу специфіки сільськогосподарської галузі є більш складним у порівнянні з іншими видами маркетингу та виокремлено особивості та ключові виклики для аграрної сфери, що впливають на практичну реалізацію аграрного марктеингу. Проведено узагальнення існуючих наукових підходів до класифікації функцій агромаркетингу та доповнено новими функціями агромарктеингу, які актуалізовані під час війни: комунікаційна, адаптивна, соціальна.  Обгрунтовано основне призначення агромаркетингу в умовах сьогодення, що полягає у побудові оптимальної системи товароруху та позиціонуванні виробленої продукції як на внутрішньому так і на міжнародних ринках.
ЦИФРОВА ТРАНСФОРМАЦІЯ РЕГІОНІВ УКРАЇНИ ЯК ПЕРЕДУМОВА ІМПЛЕМЕНТАЦІЇ КОНЦЕПЦІЇ РОЗУМНОГО МІСТА
Authors: КІЗЛЯР Олександр
Published: November 2024

The article is devoted to researching the processes of digital transformation of the regions of Ukraine through the implementation of the "smart city" concept, which is one of the key aspects of the modern development of urban areas. In the context of global trends towards digitization and the introduction of innovations, the concept of a smart city is becoming an important part of the strategic planning of both large megacities and medium and small cities. This is due to the need to adapt cities to the rapidly changing socio-economic environment, which requires more effective solutions for managing resources, improving the quality of life of residents and increasing competitiveness in the international arena. The article examines the relevance of the transition to "smart cities" in light of the challenges facing modern Ukraine, including economic, environmental and social aspects. The main challenges that stand in the way of implementing the concept of a smart city in Ukrainian regions are analyzed. Such challenges include an insufficient level of digital infrastructure, limited financial resources, a low level of digital literacy of the population, an incomplete legal framework, and an insufficient level of interaction between the public and private sectors. The article analyzes the current state of digital infrastructure in different regions of Ukraine, in particular, the level of access to broadband Internet and the implementation of intelligent transport management systems. In addition, a comparison of the implementation of smart city projects in Ukrainian cities with similar initiatives in Europe is presented, which emphasizes the need to accelerate digital transformation in the face of global competition.
Forecasting the design maxima water discharges of floods on the Latorica river according to the data of the Mukachevo gauging station using plotting position formulas
Authors: Stefanyshyn Dmytro V.
Published: November 2024

This article presents the results of forecasting design maxima discharges on the Latorica River within Mukachevo town based on hydrological observation data at the “Mukachevo” gauging station using plotting position formulas. While solving the task, a novel non-parametric method of forecasting using observation data is applied. The method includes extrapolating the discrepancy (divergence, disagreement) between the estimates of the statistical annual probabilities of exceedance obtained by different plotting position formulas. The task is considered in the frame of the stationarity hypothesis of the maximum river flow employing a time series of maximal discharges of the Latorica River observed at the “Mukachevo” gauging station from 1947 to 1999.We involved the thirteen plotting position formulas. There was no specific criterion for choosing them to solve the task. All applied formulas were considered admissible options, and results obtained after using them – expert judgments reflecting decision-makers’ predisposition to more cautious or less expensive decision options in flood management strategies.The epistemic uncertainty of the different plotting positions was reduced by employing the Fishburn rule. According to this rule, the significance of various plotting positions was given by arranging their estimates in descending order of importance of their values under decision-making. Depending on the selected significance option assignment of the different plotting position formulas, such rank-weighted estimates of the design peak discharges (each of them for annual exceedance probability 1%, 0.5%, and 0.2%) were computed: (1) the rank-weighted upper bound estimate (sup-estimate) corresponding to the predisposition to more cautious decision options; (2) the rank-weighted lower bound estimate (inf-estimate) corresponding to the predisposition to less expensive decision options. As possible control theoretical alternatives for forecasting design maximal discharges considered were five parametric probability distributions: 1) the Kritskyi-Menkel three-parameter gamma distribution; 2) Pearson’s type III distribution; 3) the Extreme value type I distribution (Gumbell’s type I distribution); 4) the Logarithmic Pearson type III distribution; and 5) the Two-parameters logarithmic-normal distribution. The population statistical parameters for these parametric probability distributions were estimated from the sample statistics by the method of moments.
Study of patterns of PM2.5 and PM10 changes in the atmospheric air of Ivano-Frankivsk region
Authors: Adamenko Stanislav Y. , Arkhypova Liudmyla M.
Published: November 2024

The purpose of this research is to analyse the temporal patterns of changes in concentrations of dust particles – aerosols, regression modeling of the interdependence of PM2.5 and PM10 at the level of instantaneous, average hourly, average daily and average weekly concentrations, and assessment of the impact of the anthropogenic component of dust pollution of atmospheric air in the Ivano-Frankivsk region on regularities of the temporal distribution of these shares.The database for the study included measurements of the concentration of PM10, PM2.5 every hour at four Ecocity public monitoring stations: in the central part of the city of Ivano-Frankivsk, in the village of Bovshiv within the influence of the Burshtyn TPP, in the village of Broshniv-Osada within the influence of the woodworking enterprise "SVISS KRONO" and within the recreational territory of the village of Mykulychyn, Nadvirnyan district. The general regularity of the temporal distribution of PM10, PM2.5 was established for all posts for daily fluctuations – the highest concentrations are observed at night, the lowest – during the period of maximum daily temperatures. It has been proven by actual data that the greater the level of atmospheric air pollution (the greater the anthropogenic component of PM), the higher the daily concentrations of PM10, PM2.5 and the more often the one-time standards of solid suspended particles are exceeded.According to the data of monitoring stations from the territories with different anthropogenic influence, functional dependences of PM2.5 content on PM10 content were obtained for instantaneous values, hourly average values, daily average values, and weekly average values. The scientific novelty of the conducted research consists in the establishment of identical functional interdependence of temporal changes in concentrations of PM2.5 and PM10 dust particles within a conditionally clean area and within the limits of the influence of stationary sources of pollution with a high level of direct regression dependence and a coefficient of determination greater than 0.9 in all cases. This allows us to conclude that the temporal patterns of changes in both PM2.5 and PM10 will not differ in clean and polluted air conditions for the Ivano-Frankivsk region. In conditions of incomplete data on the temporal distribution of the concentration of PM10, the obtained equations can be used to forecast the temporal distribution of the concentration of PM2.5.
Is the Observational Dark Energy Universe Completely a Coincidence?
Authors: Chen Angela
Published: November 2024

In this article, I propose a model that gives a ‘Not really’ answer to the question in the title: At any epoch of the universe, to an arbitrary local observer living well below the scale of Hubble horizon, the observational universe appears to be accelerated expanding. In other words, the anthropic principle might be unnecessary for the dark energy universe ‘coincidence’. In this article, the negative pressure energy density results from the variance of relative acceleration of the patches of the observational universe, thus the not perfectly uniform flow of time. I will show how such a story is qualitatively compatible with the CMB and low-redshift observations on the expansion history of our universe, while providing intriguing implications to be tested against the recently puzzling high-redshift AGNs and galaxies observations.
Psicanálise e Educação: os potenciais de grupos psicanalíticos em escolas públicas
Authors: Ivassaki Kadichary Garcia
Published: November 2024

O trabalho apresenta brevemente o cenário da educação brasileira e posiciona o ensino como uma ferramenta civilizatória, pois tem em sua constituição a repressão para operar. Dialoga-se sobre o ambiente ser essencial para a formação psíquica do indivíduo e transita-se pela ideia de que grupos psicanalíticos têm aspectos de um espaço potencial winiccottiano capaz de suportar e sustentar as investidas agressivas dos participantes, mostrando-se confiável. A partir de um relato de experiência, sugere-se que uma saída para os entraves da educação em tempos de afetos em emergência seja propiciar mais espaços de escuta em escolas públicas.
Assessing the Energy Efficiency of Saudi Arabia’s Relatively Middle Eastern Countries in the Context of Sustainable Development Goals
Authors: Alam Teg
Published: November 2024

This paper employs a non-parametric approach to assess and compare the energy efficiency of Saudi Arabia with that of other Middle Eastern countries. An approach for evaluating the performance of each unit that utilizes optimization and linear programming is data envelopment analysis (DEA). A reference set for an inefficient unit is created to facilitate the comparison of various units against the efficiency boundary and enhance the efficiency of each unit. The research employs data envelopment analysis, incorporating three input and two output variables. This approach enables Middle Eastern countries to identify ineffective measures and recall essential actions necessary for enhancement. This study's findings suggest recommendations for the effective utilization of resources. This analysis indicates that Saudi Arabia, along with certain Middle Eastern nations, exhibits greater energy efficiency than most countries in the region. When analyzing the Middle East, Saudi Arabia, United Arab Emirates, Bahrain, Cyprus, Qatar, and Turkiye are notable examples of sustainable practices requiring further investigation. Furthermore, Yemen, Lebanon, and Syria require additional scrutiny to enhance effectiveness. The proposed study presents noteworthy conclusions concerning energy efficiency. The findings are anticipated to aid government agencies in pinpointing the factors influencing development and facilitating policymaking in Middle Eastern countries.
Modifikasi Teknis Yudisial dalam Penyelesaian Sengketa Keputusan Fiktif Positif Sebagai Implikasi Berlakunya Undang-Undang Tentang Cipta Kerja
Authors: Sulaiman M. Farouq
Published: November 2024

Beberapa kalangan memaknai Pasal 175 angka 7 ayat (4) dan (5) Undang-Undang tentang Cipta Kerja (UU No. 6 tahun 2023), sebagai norma yang menghapus konsep keputusan fiktif positif dan menghilangkan kewenangan Pengadilan Tata Usaha Negara (PTUN) untuk mengadilinya, seiring dilimpahkannya ke instansi pemerintahan terkait. Melalui Penelitian doktrinal dengan menggunakan pendekatan integral terhadap ketiga UU yang mendasarinya, diperoleh pemahaman adanya modifikasi teknis yudisial dalam menyelesaikan sengketa TUN yang ditimbulkan dari adanya keputusan fiktif positif, yakni melalui prosedur berjenjang dengan menempuh upaya administrasi di instansi pemerintahan terlebih dahulu sebagai mandatory (primum remedium). Bilamana ternyata tidak mendapatkan solusi sebagaimana mestinya, barulah masyarakat yang dirugikan dapat menempuh upaya hukum (gugatan tindakan factual) ke PTUN sebagai sarana dan opsi terakhirnya (ultimum remedium).
Perlindungan Data Pribadi dalam Penegakan Hukum Pidana di Era Digital Ditinjau dari Perspektif Implementasi Prinsip Right to be Forgotten di Indonesia
Authors: Ernasari Nopit
Published: November 2024

Perlindungan data pribadi dalam penegakan hukum pidana di era digital merupakan isu krusial yang semakin relevan di Indonesia. Dengan pesatnya perkembangan teknologi informasi, data pribadi individu sering kali terancam kebocoran dan penyalahgunaan, terutama dalam konteks proses hukum. Penelitian ini mengkaji implementasi prinsip "right to be forgotten" (hak untuk dilupakan) di Indonesia sebagai langkah untuk melindungi privasi individu dan mengatur penggunaan data pribadi dalam penegakan hukum. Dalam masyarakat yang semakin terhubung secara digital, tantangan terkait privasi dan pengelolaan data pribadi menjadi sangat signifikan, terutama dalam proses hukum. Saat ini Indonesia telah memasukkan klausula hak untuk dilupakan dibeberapa aturan perundang-undangan yang sudah disahkan, bahkan sudah diatur pula system pelaksanaannya. Namun masih terdapat banyak permasalahan yang membuat hak tersebut sedikit sulit untuk menegakkan penerapannya, mengingat Indonesia juga memiliki hak untuk berpendapat dan hak untuk mengetahui informasi publik sehingga implementasi dari hak untuk dilupakan ini masih sering mengalami kritik dan kesenjangan dengan hak untuk diingat/hak untuk mengetahui
ВПЛИВ ВОЄННОГО СТАНУ НА РЕАЛІЗАЦІЮ ОСНОВНИХ ПРАВ І СВОБОД ГРОМАДЯН: ПРАВОВИЙ АНАЛІЗ
Authors: Орленко Валентина Іванівна
Published: November 2024

Анотація. У статті розглянуто вплив воєнного стану на реалізацію основних прав і свобод громадян в Україні. Воєнний стан, як надзвичайний правовий режим, вводиться з метою захисту національної безпеки та територіальної цілісності держави. Запровадження цього режиму передбачає обмеження певних прав і свобод громадян, що потребує ретельного правового аналізу для забезпечення їх правомірності та обґрунтованості. Проаналізовано законодавчі акти України, зокрема Конституцію України, закони «Про правовий режим воєнного стану» та «Про оборону України», а також міжнародні правові норми, такі як Міжнародний пакт про громадянські і політичні права. У статті визначено, які права і свободи громадян можуть бути тимчасово обмежені під час воєнного стану, серед яких право на вільне пересування, право на вільний вибір праці та право на участь в управлінні державними справами. Також розглянуто можливість втручання в особисте життя громадян під час дії воєнного стану, що включає контроль засобів зв’язку, перевірку речей та документів. Наголошено на тому, що конституційні права і свободи людини та громадянина, передбачені статтею 64 Конституції України, не можуть бути обмежені навіть в умовах воєнного стану. Це включає право на життя, право на повагу до гідності, право на свободу та особисту недоторканність, а також права, пов’язані з рівністю громадян перед законом і захистом від дискримінації. Доведено, що для ефективного захисту прав і свобод громадян під час воєнного стану необхідно не лише закріплення відповідних норм у законодавстві, але й забезпечення діяльності органів, які здійснюють контроль за дотриманням цих норм. Зокрема, значну роль відіграє інститут Уповноваженого Верховної Ради України з прав людини, який контролює та гарантує захист прав і свобод громадян. Узагальнено, що в умовах війни для підтримання безпеки та функціонування держави деякі права можуть бути обмежені, проте ці обмеження повинні бути чітко регламентовані законом і не можуть порушувати основоположні права людини. Забезпечення балансу між національною безпекою та правами людини є ключовим завданням для держави під час дії воєнного стану. Таким чином, стаття підкреслює важливість комплексного підходу до захисту прав і свобод громадян в умовах надзвичайного правового режиму.