bluuebunny/crossref_metadata_2025 huggingface dataset:
Prescription Opioids induce Gut Dysbiosis and Exacerbate Colitis in a Murine Model of Inflammatory Bowel Disease
Authors: Sharma Umakant , Olson Rohini Khatri , Erhart Federico Nicolas , Zhang Li , Meng Jingjing , Segura Bradley , Banerjee Santanu , Sharma Madhulika , Saluja Ashok Kumar , Ramakrishnan Sundaram , Abreu Maria T , Roy Sabita
Published: November 2019

Background and Aims

Opioids are the most prescribed analgesics for pain in inflammatory bowel diseases [IBD]; however, the consequences of opioid use on IBD severity are not well defined. This is the first study investigating consequences of hydromorphone in both dextran sodium sulphate [DSS]-induced colitis and spontaneous colitis (IL-10 knockout [IL-10-/-]) mouse models of IBD.

Methods

To determine the consequences of opioids on IBD pathogenesis, wild-type [WT] mice were treated with clinically relevant doses of hydromorphone and colitis was induced via 3% DSS in drinking water for 5 days. In parallel we also determined the consequences of opioids in a spontaneous colitis model.

Results

Hydromorphone and DSS independently induced barrier dysfunction, bacterial translocation, disruption of tight junction organisation and increased intestinal and systemic inflammation, which were exacerbated in mice receiving hydromorphone in combination with DSS. Hydromorphone + DSS-treated mice exhibited significant microbial dysbiosis. Predictive metagenomic analysis of the gut microbiota revealed high abundance in the bacterial communities associated with virulence, antibiotic resistance, toxin production, and inflammatory properties. Hydromorphone modulates tight junction organisation in a myosin light chain kinase [MLCK]-dependent manner. Treatment with MLCK inhibitor ML-7 ameliorates the detrimental effects of hydromorphone on DSS-induced colitis and thus decreases severity of IBD. Similarly, we demonstrated that hydromorphone treatment in IL-10-/- mice resulted in accelerated clinical manifestations of colitis compared with control mice.

Conclusions

Opioids used for pain management in IBD accelerate IBD progression by dysregulation of the gut microbiota, leading to expansion of pathogenic bacteria, translocation of bacteria, immune deregulation and sustained inflammation.
Profiling the microbial community of a Triassic halite deposit in Northern Ireland: an environment with significant potential for biodiscovery
Authors: Megaw Julianne , Kelly Stephen A , Thompson Thomas P , Skvortsov Timofey , Gilmore Brendan F
Published: November 2019

Kilroot salt mine, a Triassic halite deposit located in County Antrim, Northern Ireland, is the only permanent hypersaline environment on the island of Ireland. In this study, the microbiome of this unstudied environment was profiled for the first time using conventional and enhanced culturing techniques, and culture independent metagenomic approaches. Using both conventional isolation plates and iChip devices, 89 halophilic archaeal isolates from six known genera, and 55 halophilic or halotolerant bacterial isolates from 18 genera were obtained, based on 16S rRNA gene sequencing. The archaeal isolates were similar to those previously isolated from other ancient halite deposits, and as expected, numerous genera were identified in the metagenome which were not represented among the culturable isolates. Preliminary screening of a selection of isolates from this environment identified antimicrobial activities against a panel of clinically important bacterial pathogens from 15 of the bacterial isolates and one of the archaea. This, alongside previous studies reporting the discovery of novel biocatalysts from the Kilroot mine microbiome, suggests that this environment may be a new, untapped source of of chemical diversity with high biodiscovery potential.
A recruitment model for beech–oak pure and mixed stands in Belgium
Authors: Manso Rubén , Ligot Gauthier , Fortin Mathieu
Published: November 2019

We present a recruitment model for pure and mixed beech and oak stands in Belgium, the first empirical model for this forest type in this geographical area. Data from the Wallonia National Forest Inventory were used to fit the model. We adopted a zero-inflated formulation where model parameters governing species’ behaviour were simultaneously fitted. Plot random effects specific to each species were included, the simultaneous fit allowing them to correlate. Model predictions proved accurate and corresponded to current ecological knowledge about the regeneration dynamics of this kind of mixture. While our model could potentially be used to complement the existing beech and oak growth models for this region of Europe, our results also show that beech recruits tend to dominate regardless of the oak share in the overstorey composition and the stand stocking. This confirms that the beech–oak mixture may not be stable under the conditions of the study area and current management aimed at promoting continuous forest cover.
3-D crustal structure of the Iran plateau using phase velocity ambient noise tomography
Authors: Movaghari R , Doloei G Javan
Published: November 2019

More accurate crustal structure models will help us to better understand the tectonic convergence between Arabian and Eurasian plates in the Iran plateau. In this study, the crustal and uppermost mantle velocity structure of the Iran plateau is investigated using ambient noise tomography. Three years of continuous data are correlated to retrieve Rayleigh wave empirical Green's functions, and phase velocity dispersion curves are extracted using the spectral method. High-resolution Rayleigh wave phase velocity maps are presented at periods of 8–60 s. The tomographic maps show a clear consistency with geological structures such as sedimentary basins and seismotectonic zones, especially at short periods. A quasi-3-D shear wave velocity model is determined from the surface down to 100 km beneath the Iran plateau. A transect of the shear wave velocity model has been considered along with a profile extending across the southern Zagros, the Sanandaj-Sirjan Zone (SSZ), the Urumieh-Dokhtar Magmatic Arc (UDMA) and Central Iran and Kopeh-Dagh (KD). Obvious crustal thinning and thickening are observable along the transect of the shear wave velocity model beneath Central Iran and the SSZ, respectively. The observed shear wave velocities beneath the Iran plateau, specifically Central Iran, support the slab break-off idea in which low density asthenospheric materials drive towards the upper layers, replacing materials in the subcrustal lithosphere.
Access to paediatric cancer care treatment in Mexico: responding to health system challenges and opportunities
Authors: Doubova Svetlana V , Knaul Felicia Marie , Borja-Aburto Víctor Hugo , Garcia-Saíso Sebastian , Zapata-Tarres Marta , Gonzalez-Leon Margot , Sarabia-Gonzalez Odet , Arreola-Ornelas Héctor , Pérez-Cuevas Ricardo
Published: November 2019

In Mexico, paediatric cancer is the leading cause of death for children aged 0–18 years. This study analyses the main challenges for paediatric cancer care from the perspective of three key health systems functions: stewardship, financing and service delivery. The study used a mixed methods approach comprised of: (1) a scoping literature review, (2) an analysis of 2008–18 expenditures on paediatric cancer by the Fund for Protection against Catastrophic Expenditures (FPGC) of Seguro Popular and (3) a nation-wide survey of the supply capacity of 59 Ministry of Health (MoH) and 39 Mexican Institute of Social Security (IMSS) hospitals engaged in paediatric cancer care. The study found that while Mexico has made substantial progress towards universal health coverage (UHC) for paediatric cancer treatment, serious gaps persist. FPGC funds for paediatric cancer increased from 2008 to 2011 to reach US$36 million and then declined to US$13.6 million in 2018, along with the number of covered cases. The distribution of health professionals and paediatric oncology infrastructure is uneven between MoH and IMSS hospitals and across Mexican regions. Both institutions share common barriers for continuous and co-ordinated health care and lack monitoring activities that cripple their capacity to apply uniform standards for high-quality cancer care. In conclusion, achieving universal and effective coverage of paediatric cancer treatment is a critical component of UHC for Mexico. This requires periodic and ongoing assessment of health system performance specific to paediatric cancer to identify gaps and propose strategies for continued investment and improvement of access to care and health outcomes for this important cause of premature mortality.
Uniqueness of Real Lagrangians up to Cobordism
Authors: Kim Joontae
Published: November 2019

We prove that a real Lagrangian submanifold in a closed symplectic manifold is unique up to cobordism. We then discuss the classification of real Lagrangians in ${\mathbb {C}} P^2$ and $S^2\times S^2$. In particular, we show that a real Lagrangian in ${\mathbb {C}} P^2$ is unique up to Hamiltonian isotopy and that a real Lagrangian in $S^2\times S^2$ is either Hamiltonian isotopic to the antidiagonal sphere or Lagrangian isotopic to the Clifford torus.
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I
Authors: Gregson J , Rhee S Y , Datir R , Pillay D , Perno C F , Derache A , Shafer R S , Gupta R K
Published: November 2019

Background

M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance and increased tenofovir disoproxil fumarate (TDF) susceptibility. Nonetheless, 3TC and FTC (collectively referred to as XTC) appear to retain modest activity against human immunodeficiency virus-1 with these mutations possibly as a result of reduced replication capacity. In this study, we determined how M184V/I impacts virus load (VL) in patients failing therapy on a TDF/XTC plus nonnucleoside reverse-transcriptase inhibitor (NNRTI)-containing regimen.

Methods

We compared VL in the absence and presence of M184V/I across studies using random effects meta-analysis. The effect of mutations on virus reverse-transcriptase activity and infectiousness was analyzed in vitro.

Results

M184I/V was present in 817 (56.5%) of 1445 individuals with virologic failure (VF). Virus load was similar in individuals with or without M184I/V (difference in log10 VL, 0.18; 95% confidence interval, .05–.31). CD4 count was lower both at initiation of antiretroviral therapy and at VF in participants who went on to develop M184V/I. L74I was present in 10.2% of persons with M184V/I but absent in persons without M184V/I (P < .0001). In vitro, L74I compensated for defective replication of M184V-mutated virus.

Conclusions

Virus loads were similar in persons with and without M184V/I during VF on a TDF/XTC/NNRTI-containing regimen. Therefore, we did not find evidence for a benefit of XTC in the context of first-line failure on this combination.
Characterizing non-heroin opioid overdoses using electronic health records
Authors: Averitt Amelia J , Slovis Benjamin H , Tariq Abdul A , Vawdrey David K , Perotte Adler J
Published: November 2019

Introduction

The opioid epidemic is a modern public health emergency. Common interventions to alleviate the opioid epidemic aim to discourage excessive prescription of opioids. However, these methods often take place over large municipal areas (state-level) and may fail to address the diversity that exists within each opioid case (individual-level). An intervention to combat the opioid epidemic that takes place at the individual-level would be preferable.

Methods

This research leverages computational tools and methods to characterize the opioid epidemic at the individual-level using the electronic health record data from a large, academic medical center. To better understand the characteristics of patients with opioid use disorder (OUD) we leveraged a self-controlled analysis to compare the healthcare encounters before and after an individual’s first overdose event recorded within the data. We further contrast these patients with matched, non-OUD controls to demonstrate the unique qualities of the OUD cohort.

Results

Our research confirms that the rate of opioid overdoses in our hospital significantly increased between 2006 and 2015 (P < 0.001), at an average rate of 9% per year. We further found that the period just prior to the first overdose is marked by conditions of pain or malignancy, which may suggest that overdose stems from pharmaceutical opioids prescribed for these conditions.

Conclusions

Informatics-based methodologies, like those presented here, may play a role in better understanding those individuals who suffer from opioid dependency and overdose, and may lead to future research and interventions that could successfully prevent morbidity and mortality associated with this epidemic.
Development and validation of the Simulator of the Canine Intestinal Microbial Ecosystem (SCIME)1
Authors: Duysburgh Cindy , Ossieur Wendy P , De Paepe Kim , Van den Abbeele Pieter , Vichez-Vargas Ramiro , Vital Marius , Pieper Dietmar H , Van de Wiele Tom , Hesta Myriam , Possemiers Sam , Marzorati Massimo
Published: November 2019

Whereas a wide variety of in vitro models have been developed and validated to assess the effect of specific food ingredients on the human gut microbiome, such models have only been developed and applied to a limited extent for companion animals. Since the use of pre- and probiotics to improve gut health is an emerging research topic in the field of companion animals and as dogs are often used as laboratory animals in developing and testing of pharmaceuticals, the current study aimed to establish an adequate canine in vitro model. This consisted of a four-stage reactor composed of a stomach and small intestinal compartment followed by a proximal and distal colon. This semi-continuous gastrointestinal tract model allowed a long-term, region-dependent, and pH-controlled simulation of the colon-associated microbial community of dogs. Upon reaching a functional steady state, the simulated canine microbial community composition proved to be representative of the in vivo situation. Indeed, the predominant bacterial phyla present in the in vitro proximal and distal colon corresponded with the main bacterial phyla detected in the fecal material of the dogs, resulting in an average community composition along the simulated canine gastrointestinal tract of 50.5% Firmicutes, 34.5% Bacteroidetes, 7.4% Fusobacteria, 4.9% Actinobacteria, and 2.7% Proteobacteria. A parallel in vivo–in vitro comparison assessing the effects of fructooligosaccharides (FOS) on the canine microbial community composition showed a consistent stimulation of Lactobacillus concentrations in the in vivo fecal samples as well as in the in vitro canine gut model. Furthermore, the in vitro platform provided additional insights about the prebiotic effect of FOS supplementation of dogs, such as a reduced abundance of Megamonas spp. which are only present in very low abundance in in vivo fecal samples, indicating an interesting application potential of the developed canine in vitro model in research related to gastrointestinal health of dogs.
Nontarget Host Risk Assessment of the Egg Parasitoid Trichogrammatoidea cryptophlebiae (Hymenoptera: Trichogrammatidae) for Classical Biological Control of the False Codling Moth (Lepidoptera: Tortricidae) in Israel
Authors: Kaspi Roy , Steinitz Hadass , Nemny-Lavi Esther , Lebedev Galina , Melamed Ester , Gazit Yoav
Published: November 2019

The false codling moth Thaumatotibia leucotreta (Meyrick), is an invasive species in Israel. In order to carry out a classical biological control program, the African egg parasitoid Trichogrammatoidea cryptophlebiae (Nagaraja) was recently introduced into Israel, and nontarget host risk assessment was performed as required. In no-choice tests we determined that T. cryptophlebiae was unable to develop in eggs of four nontarget Lepidopteran species: Pectinophora gossypiella (Saunders), Spodoptora littoralis (Boisduval), Ephestia kuehniella (Zeller), and Belenois aurota (Fabricius). Conversely, it developed in three Lepidopteran species eggs of the Tortricidae family: Cydia pomonella (Linnaeus), Lobesia botrana (Denis and Schiffermüller), and Epiblema strenuana (Walker). Epiblema strenuana eggs showed the lowest parasitism level among all tested moth eggs of the Tortricidae family. The progeny production of parasitized false codling moth eggs was similar to that of C. pomonella eggs, but smaller than that of L. botrana eggs. However, moth egg and parasitoid clutch sizes were smallest on L. botrana eggs and largest on C. pomonella eggs. In choice bioassays, T. cryptophlebiae significantly preferred to parasitize T. leucotreta eggs over the eggs of C. pomonella, L. botrana, and E. strenuana. Moreover, the choice of T. leucotreta eggs over the eggs of L. botrana was not affected by the parasitoids’ rearing histories. Our data support the assumption that T. cryptophlebiae develops only in moth species of the Tortricidae family. Thus, the risk that it may attack nontarget species is low.
Early Season Applications of Bifenthrin Suppress Host-seeking Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) Nymphs
Authors: Schulze Terry L , Jordan Robert A
Published: November 2019

We assessed the efficacy of bifenthrin to suppress Ixodes scapularis Say and Amblyomma americanum (L.) nymphs when applied prior to the initiation of spring host-seeking activity versus when nymphs were already active. Treatment and control plots were sampled for host-seeking ticks every week from mid-April through June, and single occasion bifenthrin applications were done in different sets of treatment plots on 15 April, 29 April, 13 May, and 27 May. Ixodes scapularis nymphs and A. americanum nymphs and adults were effectively suppressed after each application, with at or near 100% suppression of all ticks being observed for up to 8-wk postapplication. Irrespective of the bifenthrin application date, the level of suppression of I. scapularis nymphs never declined below 70% during the study period. However, with the exception of the last application, the suppression of A. americanum nymphs decreased dramatically to below 25% by the conclusion of the trial. The results of this study demonstrated that preseason applications of bifenthrin can mitigate acarological risk of exposure to ticks throughout much of their spring peak activity period.
What Is Going on With the Genus Dermacentor? Hybridizations, Introgressions, Oh My!
Authors: Goddard Jerome , Allerdice Michelle , Portugal J Santos , Moraru Gail M , Paddock Christopher D , King Jonas
Published: November 2019

In the 1930s, R. A. Cooley noted that Dermacentor occidentalis (Acarina: Ixodidae) and Dermacentor andersoni were closely related and could hybridize. Decades later, James Oliver discovered that crosses of Dermacentor variabilis, D. andersoni, and D. occidentalis could, on occasion, produce hybrids. A recent molecular analysis (both mtDNA and nDNA) in our laboratory revealed that certain specimens of Dermacentor andersoni nested with Dermacentor parumapertus. Does this close relationship, along with the mito-nuclear discordance we have observed, mean D. andersoni and D. parumapertus are a single species? By contemporary taxonomic criteria, this seems improbable based on their distinctly different morphologies, host associations, and ecologies. This paper explores ideas related to mito-nuclear discordance, hybridization, and introgression (primarily) not only in these two species but also other members of the genus Dermacentor. Both D. andersoni and D. parumapertus can be found on the same hosts and have sympatric distributions, so introgression of genetic material by occasional cross-mating between these two species is possible. Further, the difficulty in applying specific species concepts in ticks has been recently pointed out and a unified agreement on an integrative species concepts could clearly be useful in this situation. With the discovery of D. parumapertus as a potential vector of Rickettsia parkeri and the historically recognized role of D. andersoni in transmission of Rickettsia rickettsii, understanding the specific status of each lineage of these species (and others in the genus) is extremely important from a public health perspective.
Identifying Cancer-Related Cognitive Impairment Using the FACT-Cog Perceived Cognitive Impairment
Authors: Dyk Kathleen Van , Crespi Catherine M , Petersen Laura , Ganz Patricia A
Published: November 2019

Cancer-related cognitive impairment (CRCI) is a concerning problem for many cancer survivors. Evaluating patients for CRCI has been a challenge, in part because of a lack of standardized practices. Self-report instruments are often used to assess CRCI, but there are no validated cutpoints. We present the results of receiver operating characteristic curve analysis identifying cutpoints of the Functional Assessment of Cancer Therapy—Cognition perceived cognitive impairment (PCI) in female breast cancer survivors for identifying CRCI cases. We defined presence of CRCI based on elevated complaints on the Patient’s Assessment of Own Functioning Inventory compared with healthy control scores. Our results indicate that scores less than 54 in PCI scores using 18 items and scores less than 60 in PCI scores using 20 items exhibited good ability to discriminate CRCI cases from noncases (area under the receiver operating characteristic curve was 0.84 [95% CI = 0.73 to 0.94]). These preliminary results represent an important contribution toward standardizing practices across CRCI studies.
Disjunction Triggers Exhaustivity Implicatures in 4- to 5-Year-Olds: Investigating the Role of Access to Alternatives
Authors: Gotzner Nicole , Barner David , Crain Stephen
Published: November 2019

Children’s difficulty deriving scalar implicatures has been attributed to a variety of factors including processing limitations, an inability to access scalar alternatives, and pragmatic tolerance. The present research explores the nature of children’s difficulty by investigating a previously unexplored kind of inference—an exhaustivity implicature that is triggered by disjunction. We reasoned that if children are able to draw quantity implicatures but have difficulties accessing alternative lexical expressions from a scale, then they should perform better on exhaustivity implicatures than on scalar implicatures, since the former do not require spontaneously accessing relevant scalar alternatives from the lexicon. We conducted two experiments. Experiment 1 found that 4- to 5-year-olds consistently computed exhaustivity implicatures to a greater extent than scalar implicatures. Experiment 2 demonstrated that children are more likely to compute exhaustivity implicatures with disjunction compared to conjunction. We conclude that children often fail to derive scalar implicatures because (1) they struggle to access scalar alternatives and (2) disjunction (but not conjunction) makes subdomain alternatives particularly salient. Thus, the findings suggest that exhaustivity implicatures can be derived without reference to a scale of alternatives.
Mechanical intestinal obstruction following laparoscopic inguinal hernia repair in a patient with abdominal cocoon syndrome
Authors: Park Geon Hi , Lee Byoung Chul , Hyun Dong woo , Choi Jung Bum , Park Young Mok , Jung Hyuk Jae , Jo Hong Jae
Published: November 2019

Abdominal cocoon syndrome (ACS) is a rare condition characterized by partial or complete encasement of small intestine by a thick fibro-collagenous membrane. A 65-year-old man presented to the surgical department with left inguinal. He underwent laparoscopic transabdominal preperitoneal inguinal hernia. When we inserted a trocar into the peritoneal cavity, the small intestine was injured and repaired immediately. We identified a fibrotic membrane covering the small intestine, which was found as ACS. Two weeks later after discharge, he presented to the emergency department with mechanical intestinal obstruction. Conservative treatment had no effect on the patient and membrane excision, adhesiolysis and small intestine resection with anastomosis were performed. Unfortunately, the patient was hospitalized for a long time with bowel leakage and discharged on postoperative day 48. The preoperative diagnosis is quite challenging and most cases are diagnosed intraoperatively. When finding the ACS during the operation, careful attention should be needed.
Non-stationary Antonov self-gravitating layer: analytics and numerics
Authors: Malkov Evgeny A , Kudryavtsev Alexey N
Published: November 2019

Large-scale instability of gravitating systems plays a key role in collisionless relaxation and in reaching a quasi-stationary state at the early stage of evolution. Advanced high-resolution methods and permanently increasing performance of computational systems allow this phenomenon to be studied by means of computer simulations at a new level. In this paper, an approach to verification and validation of computer codes implementing high-resolution methods is proposed. The approach is based on comparisons of the simulation results with exact non-stationary solutions of the Vlasov–Poisson equations. The evolution of the gravitating layer model is considered as an example of implementation of this approach. A one-parameter family of exact models of a non-stationary gravitating layer is described, and their stability to large-scale disturbances in the linear approximation is analytically studied. Non-linear instability development is computed with the use of the fifth-order conservative semi-Lagrangian WENO scheme.
Spectral signatures of recursive magnetic field reconnection
Authors: Tenerani A , Velli M
Published: November 2019

We use 2.5D magnetohydrodynamic simulations to investigate the spectral signatures of the non-linear disruption of a tearing unstable current sheet via the generation of multiple secondary current sheets and magnetic islands. During the non-linear phase of tearing mode evolution, there develops a regime in which the magnetic energy density shows a spectrum with a power law close to B(k)2 ∼ k−0.8. Such an energy spectrum is found in correspondence of the neutral line, within the diffusion region of the primary current sheet, where energy is conveyed towards smaller scales via a ‘recursive’ process of fast tearing-type instabilities. Far from the neutral line, we find that magnetic energy spectra evolve towards slopes compatible with the ‘standard’ Kolmogorov spectrum. Starting from a self-similar description of the non-linear stage at the neutral line, we provide a model that predicts a reconnecting magnetic field energy spectrum scaling as k−4/5, in good agreement with numerical results. An extension of the predicted power law to generic current sheet profiles is also given and possible implications for turbulence phenomenology are discussed. These results provide a step forward to understand the ‘recursive’ generation of magnetic islands (plasmoids), which has been proposed as a possible explanation for the energy release during flares, but which, more in general, can have an impact on the subsequent turbulent evolution of unstable sheets that naturally form in the high Lundquist number and collisionless plasmas found in most of the astrophysical environments.
Quantifying acetaldehyde in astronomical ices and laboratory analogues: IR spectra, intensities, 13C shifts, and radiation chemistry
Authors: Hudson Reggie L , Ferrante Robert F
Published: November 2019

Acetaldehyde is of interest to astrochemists for its relevance to both interstellar and cometary chemistry, but little infrared (IR) spectral data have been published for the solid phases of this compound. Here we present IR spectra of three forms of solid acetaldehyde, with spectra for one form being published for the first time. Direct measurements of band strengths and absorption coefficients also are reported for the first time for amorphous aldehyde, the form of greatest interest for astrochemical work. An acetaldehyde band strength at ∼1350 cm−1 that has been used as a reference for about 20 yr is seen to be in error by about 80 per cent when compared to the direct measurements presented here. Spectra and peak positions also are presented for H13C(O)13CH3, and then used for the first identification of ketene as a radiation product of solid acetaldehyde.
Factors Influencing Smoking Among Indigenous Adolescents Aged 10–24 Years Living in Australia, New Zealand, Canada, and the United States: A Systematic Review
Authors: Heris Christina L , Chamberlain Catherine , Gubhaju Lina , Thomas David P , Eades Sandra J
Published: November 2019

Introduction

Smoking rates are higher among Indigenous populations in most high-income countries with initiation primarily occurring in adolescence for all population groups. This review aims to identify protective and risk factors for smoking behavior among Indigenous adolescents and young adults.

Aims and Methods

We searched Medline, Embase, and Psychinfo for all original research published between January 2006 and December 2016 that reported influences on smoking for Indigenous adolescents or young adults aged 10–24 living in Australia, New Zealand, Canada, and the United States (US). Extracted data were coded to individual, social, and environmental level categories using a modified Theory of Triadic Influence framework.

Results

A total of 55 studies were included, 41 were descriptive quantitative and 14 qualitative, and 26 included Indigenous participants only. The majority were from the US (32). Frequently reported influences were at the individual and social levels such as increasing age; attitudes and knowledge; substance use; peer and family relationships; smoking norms; mental health; physical activity. At the environmental level, smoke-free spaces; second-hand smoke exposure; high community level prevalence; and social marketing campaigns were also frequently reported. Some studies referenced price, access, and traditional tobacco use. Few reported historical and cultural factors.

Conclusions

Young Indigenous people experience similar influences to other populations such as smoking among family and friends. Greater youth smoking is related to broader community level prevalence, but few studies explore the distal or historical contributing factors such as traditional tobacco use, colonization, experiences of intergenerational trauma and discrimination, or the role of cultural connection.

Implications

This review identified a range of factors that influence Indigenous youth smoking and contributes to an understanding of what prevention measures may be effective. Youth tobacco use occurs alongside other substance use and may also serve as an indicator of mental health. Comprehensive community-based programs that work more broadly to address the risk factors related to tobacco, including improving youth mental health, will be important for other behaviors as well. This research highlights the importance of social influence and need for ongoing denormalization of smoking. Future Indigenous led and community owned research is needed to identify likely protective cultural factors.
Spatial Statistics
Authors: Griffith Daniel A. , Chun Yongwan
Published: November 2019

Spatial statistics (SS)—statistics that address and account for the correlations among georeferenced observations arising from their relative locations in geographic space (i.e., spatial autocorrelation [SA])—has a formal history dating to the mid-1900s, although conceptual awareness of it dates back to the very early 1900s. It is a special case of correlated data. It arises from a relaxation of the independent observations assumption of classical statistics. Its development emphasized the following three themes: point pattern analysis, spatial autoregression, and geostatistics. Point pattern analysis was a precursor to spatial autoregression, whereas these latter two themes evolved in parallel, with little cross-fertilization during most of their first 40 years of development, primarily because spatial autoregression was the preferred interest of English-speaking scholars, whereas geostatistics was the preferred interest of French-speaking scholars. Much of the early work treated point patterns; spatial autoregression and geostatistics began eclipsing this emphasis around 1990. SS is best understood after completion of a course in multivariate statistical analysis. Spatial Autocorrelation, the book by Cliff and Ord in 1973 initiated a popularizing of SS in the early 1970s; later, Spatial Econometrics, by Paelinck and Klaassen in 1979, extended it to spatial econometrics. The important message is that accounting for SA in georeferenced data really matters in the environmental sciences.
Orthodoxy
Authors: Fuchs Ilan
Published: November 2019

The term Orthodox comes from the Greek, meaning “the right idea.” In Jewish communities, Orthodoxy is used to identify a theological and sociological stream in the modern period. From a theological perspective, the term is used to signify the belief that canonical Jewish texts are divine, and that the Halakha (or Halacha), the Jewish legal system, is binding. The Jewish historian Jacob Katz (b. 1904–d. 1998) saw Orthodoxy as a phenomenon that developed in the modern era as a response to secularization. This response created a critical dialogue with modernity that leads Orthodox communities to selectively choose and legitimize parts of the modern experience, creating a spectrum of Orthodoxies with many different sociological variables determined by the extent of integration with modernity (e.g., in Israel, Orthodoxy spans a spectrum from religious Zionism to Haredi [or Charedi] Judaism). The sociologist Menachem Friedman points to several common attributes to Orthodoxy, mainly its rejection of secular society and the emphasis that Orthodox discourse puts on the past as a lost idyllic reality that should be resurrected. Geographically and chronologically, Orthodoxy spans many spaces. It morphs in many ways, and its manifestation in 19th-century Russia is very different from its evolution in interwar Poland or post-Holocaust Israel. But in these different situations and historical contexts, Orthodoxy developed very clear theological and political agendas, all based on a shared textual traditions that allows for transitions between different Orthodox communities, such as modern Orthodoxy in the United States. The Orthodox ethos stems from the positions of Rabbi Moshe Sofer (b. 1762–d. 1839), known as the Chatam Sofer, who had to craft a policy reacting to acculturation, secularization, and assimilation in Germany and Hungary. He promoted a policy of creating fences around the observant Jewish community, preventing the influence of secularism by celebrating particularism and emphasizing the need to maintain a separate Jewish sphere with the most minimal connections to the non-Jewish world.
Nightlife
Authors: Shaw Robert
Published: November 2019

The study of nightlife, or the “nighttime economy,” is the study of nocturnal leisure and entertainment. It is not a uniquely geographical theme; the emergent field of night studies also incorporates research from history, urban studies, sociology, cultural studies, anthropology, biomedical sciences, and other disciplines. Despite this range of interventions, when the word nightlife is used in both everyday and academic language, it almost always refers to a specific portion of nighttime activity, usually taking place in pubs, bars, and restaurants, incorporating alcohol drinking, dancing, eating, and socializing. This article both aims to introduce work that has studied this “dominant” nightlife, and also suggests examples of research and sites where different or alternative nightlives are present. Researchers have shown how nightlife has grown with the spread and extension of capitalism and the growth of the leisure society. In its contemporary form, nightlife has become associated with neoliberal capitalism, as reduced regulations on alcohol retail and consumption in many countries have encouraged the growth of nightlife. Through globalization, and in particular through the emergence of global cities that seek to compete for relatively footloose business people, the “creative class,” and tourists, Western-style nightlife has spread as a tick-box on the list of criteria for being a global city, with new forms of associated governance such as “night mayors.” Relatedly, research has been dominated by the European and Anglophone cities from which this nightlife has emerged, though the structural biases of academic practice have also contributed to this. This article inevitably reflects those biases, but examples of research from Asia, Africa, and South America are also included. Beyond the political and economic spread of neoliberal nighttime economy, nightlife also has important cultural resonances. Both mainstream and alternative nightlife cultures offer insights into everyday life, and included in the bibliography are some of the detailed and evocative ethnographies of different nightlife sites and communities. The experience of nightlife is inevitably differentiated according to commonly recognized grounds of intersecting social groupings: race, class, gender, religion, and so forth. Papers in this article introduce some of these differences, and the inclusions or exclusions associated with them.
C2 Pedicle Screws Combined With C1 Laminar Hooks for Reducible Atlantoaxial Dislocation: An Ideal Salvage Technique for C1-C2 Pedicle Screws
Authors: Han Zhao , Yang Jun , Chen Qunxiang , Lu Xuhua , Chen Fei , Guo Xiang , Ni Bin , Guo Qunfeng
Published: November 2019

BACKGROUND

A C1 laminar hook can theoretically avoid vertebral artery injury and is less technically demanding. However, only few studies with small samples analyzed the short-term outcomes of C2 pedicle screws combined with C1 laminar hooks (C2PS-C1LH) technique in the treatment of atlantoaxial dislocation. Furthermore, it is not confirmed whether similar clinical outcomes can be achieved with C1-C2 pedicle screw and rod construct (PSRC).

OBJECTIVE

To evaluate the outcomes of C2PS-C1LH and C1-C2 PSRC fixation techniques for treating atlantoaxial dislocation.

METHODS

Data of 52 patients with atlantoaxial dislocation treated by C1-C2 PSRC or C2PS-C1LH fixation were retrospectively reviewed. Outcomes evaluated by visual analog scale score for neck pain (VASSNP), Neck Disability Index (NDI), atlantodental interval (ADI), and the perioperative parameters including blood loss and operation time were analyzed and compared between 2 techniques. Patient satisfaction at final follow-up was also investigated.

RESULTS

There were no complications related to the surgical approach and instrumentation in either group. The mean bone fusion time was 5.06 ± 1.65 mo for the C2PS-C1LH group and 3.93 ± 0.99 mo for the C1-C2 PSRC group (P > .05). Hundred percent of fusion rates were achieved in both groups at month 12 after operation. The ADI, VAS scores, the NDI scores, and the JOA scores were greatly improved in both the groups (P < .05), but there were no significant differences between the 2 groups.

CONCLUSION

C2PS-C1LH fixation technique was comparable to C1-C2 PSRC in the treatment of reducible atlantoaxial dislocation. C2PS-C1LH fixation was an ideal alternative strategy to C1-C2 PSRC fixation.
Surgery for Brainstem Cavernous Malformations: Association between Preoperative Grade and Postoperative Quality of Life
Authors: Lashkarivand Aslan , Ringstad Geir , Eide Per Kristian
Published: November 2019

BACKGROUND

Brainstem cavernous malformations (BSCMs) are associated with substantial neurologic morbidity, but the literature on quality of life (QoL) after surgical treatment is limited. There is a need for validating the clinical utility of current grading scales for cavernous malformations.

OBJECTIVE

To assess outcome of surgery for BSCMs and validate how outcome is associated with current grading scales for cavernous malformations.

METHODS

We retrospectively reviewed a single-surgeon series of patients with BSCM treated surgically during a 10-yr period. Outcome was categorized according to modified Rankin Scale (mRS), and QoL was assessed by interviewing patients using Short Form 36 (SF-36) Health Survey and comparing results with the normative population. The mRS and QoL were correlated with the Lawton BSCM grading scale and with the Zabramski classification of cavernous malformations.

RESULTS

The study included 22 patients (12 males and 10 females; median age 58 yr). No mortality related to the BSCM surgery occurred, and none were in vegetative state. In SF-36, 70% of patients reported a physical and mental functioning noninferior compared to the general population of comparative age and gender group. There was a significant positive correlation between the Lawton BSCM grading and the postoperative mRS score and QoL.

CONCLUSION

Outcome of surgery for BSCM was good, as assessed by mRS and QoL. The Lawton grading scale for BSCMs correlated significantly with the postoperative mRS score and QoL, suggesting this grading scale may become a useful clinical tool for treatment prognostication at the individual level.
Pain Management Telementoring, Long-term Opioid Prescribing, and Patient-Reported Outcomes
Authors: Flynn Diane , Doorenbos Ardith Z , Steffen Alana , McQuinn Honor , Langford Dale J
Published: November 2019

Objective

Benefits of primary care provider (PCP) participation in pain management telementoring have been reported; however, no studies have examined within-patient changes in dose or discontinuation of long-term opioid therapy (LOT). The objectives of this nonrandomized study were to evaluate the relationship between telementoring participation and 1) LOT dose reduction and 2) LOT discontinuation and to 3) explore the relationship between LOT dose changes and patient-reported outcomes.

Methods

PCPs were recruited from a US Army medical center. Intervention group PCPs (N = 12) attended telementoring sessions; control group providers (N = 13) did not. Morphine equivalent daily doses (MEDD) for patients of study providers (N = 396) were extracted from the study site’s opioid database. The intervention group was subdivided based on number of sessions attended (i.e., active and low participation). Intent-to-treat and as-treated analyses were conducted using generalized estimating equations. Separate analyses evaluated the association between within-patient changes in MEDD and pain impact, depression, and anxiety (N = 40).

Results

Intent-to-treat analysis revealed no significant difference in MEDD reduction; however, a higher proportion of patients of intervention PCPs discontinued LOT (25% ± 3.6%) compared with control PCPs (16% ± 3.6%, P < 0.05). As-treated analyses revealed differences in MEDD reduction between active (13.2 ± 3.0) and low-participating (2.6 ± 3.0) PCPs (P < 0.01). Further, a higher proportion of patients of actively participating PCPs discontinued LOT (29% ± 4.9%) compared with control PCPs (16% ± 3.6%, P = 0.01). We found no evidence that decreased MEDD was associated with poorer self-reported outcomes within patients.

Conclusions

Pain management telementoring supports PCPs’ efforts to reduce reliance on LOT for chronic pain management and highlights the need for actively engaged PCP pain champions.
MEASUREMENT OF EXTREMITY DOSES OF NUCLEAR ENERGY WORKER BY USING RING DOSIMETER
Authors: Islam M Tahidul , Ferdous J , Haque M M
Published: November 2019

Finger doses can serve as a guide to suggest any needed modification in work practice to minimise radiation doses to the extremities. In the present study, radiation doses at the base of the middle finger of both hands of 20 nuclear energy workers handling 99mTc-labelled compounds,125I and131I during various diagnostic and therapeutic procedures in nuclear medicine were measured. The laboratory assessments were carried out by means of thermoluminescence ring dosimetry in Health Physics Division, Atomic Energy Center, Dhaka. The recorded extremity doses were then compared to their routinely monitored whole-body doses. The average annual finger doses recorded in this study were found to be 10.7 ± 8.2 and 12.7 ± 12.9 mSv, respectively, for the left- and right-hand fingers, which are at least 12-fold higher than the average whole-body dose. There was, however, no extreme case found of health hazard to the workers’ hand, which exceeds maximum dose limit 500 mSv/year given by the International Commission on Radiological Protection. On comparing the average annual finger doses at different labs, significantly higher average dose was recorded at isotope-dispensing lab (19.6 ± 12.6 mSv/year) and then followed by gamma camera lab (13.2 ± 12.1 mSv/year) and radioimmunoassay lab (7.0 ± 5.5 mSv/year). These observations are fairly in good agreement with the reported results. The observations of the present study, therefore, may be implemented for the betterment of safety for the occupational workers in nuclear medicine facilities.
226Ra AND 228Ra CONCENTRATIONS IN SOILS WITH INTENSE GROUNDWATER IRRIGATION IN AN ARID ENVIRONMENT
Authors: Ebaid Y Y
Published: November 2019

The enhancing effect due to long-time irrigation with radium-containing groundwater on soil was investigated in this work. Samples from the Al-Qassim and Hail areas in Saudi Arabia were studied for their 226Ra and 228Ra inventories. Groundwater and soil samples were collected from 32 farms where agricultural activities are intensively irrigated with radium-containing groundwater. A noticeably good correlation was observed between radium isotopes inventories in the groundwater used for irrigation with those in the associated soils. It was concluded that there are enhanced levels of radium isotopes in the soils due to the existence of radium isotopes in irrigated groundwater. The additional annual effective dose values ranged between 0.00 and 0.412 with an average of 0.09 mSv y−1.
The dynamics of ‘Moralized Markets’: a field perspective
Authors: Balsiger Philip
Published: November 2019

This article describes the distinctive features and structural properties of ‘moralized markets’, that is, markets in which producers set higher moral standards than those governing conventional market practices, and consumers buy products that respect those higher moral standards. Starting from a critical discussion of existing theoretical conceptualizations in terms of conventionalization/co-optation, quality conventions and resource partitioning, this article conceptualizes moralized markets as fields where actors are in strategic interaction. Using illustrations from several empirical studies, it suggests that all moralized markets are composed of a plurality of actors whose understanding of and commitments to moral principles vary. It reveals the main dimensions of the field, characterizes typical positions, and identifies and describes the core strategies used in struggles around field boundaries and the issues of policing and regulation of field settlements. The article concludes by offering six propositions regarding different possible outcome scenarios for the dynamics of moralized market fields, highlighting the role of the state for the stabilization of field settlements.
Professionalisation and Professionalism: Diphtheria and Medical Practice in Minnesota 1850–1910
Authors: Rushton Alan R
Published: November 2019

The evolution of professionalism in Minnesota began when allopathic and homeopathic physician leaders organised medical societies and colleges to define and perpetuate their styles of practice. The epidemics of diphtheria that ravaged the state demanded prompt public health measures of quarantine to reduce the spread of the disease. Then the successful utilization of diphtheria antitoxin in Europe encouraged its local production in Minnesota and the re-education of all physicians there to convince them that they were no longer helpless to treat this infection that killed so many children. Their professionalisation was completed when they implemented the cure for diphtheria that laboratory science had produced. Homeopathic and allopathic practices converged as Minnesota physicians transformed their occupation from merely caring and comforting to actively treating and curing a serious infection.