bluuebunny/crossref_metadata_2025 huggingface dataset:
The edible tomato COVID-19 vaccine, TOMAVAC, induces neutralising IgGs
Authors: Abdurakhmonov Ibrokhim , Buriev Zabardast , Shermatov Shukhrat , Usmanov Dilshod , Mirzakhmedov Mukhammadjon , Ubaydullaeva Khurshida , Kamburova Venera , Rakhmanov Bakhtiyor , Ayubov Mirzakamol , Abdullaev Adkham , Eshmurzaev Jakhongir , Mamajonov Behzod , Tulanov Akmal , Ismailova Adolat , Petrova Tatyana , Rozumbetov Ramazan , Aripova Tamara , Muminov Muzaffar , Ermatova Khusnora , Dalimova Dilbar , Turdikulova Shahlo , Abdukarimov Abdusattor
Published: January 2023

Plant-based edible vaccines that provide two-layered protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outweigh the currently used parenteral type of vaccines, predominantly causing a systemic immune response. Here we engineered and selected the transgenic tomato genotype (TOMOVAC), stably synthesising an antigenic S1 protein of SARS-COV-2. Two-course spaced force-feeding of mice with ≈5.4 µg/ml TOMAVAC increased up to 16-fold synthesis of RBD-specific NAbs in blood serums. TOMAVAC-induced NAbs had 15-25% viral neutralising activity in a surrogate virus neutralisation test. Results suggested early evidence of immunogenicity and protectivity of TOMAVAC against COVID-19 infection. Further, we observed a positive trend of statistically significant 1.2-fold (average of +42.28 BAU/ml) weekly increase in NAbs in the volunteers’ serum relative to the initial day. No severe side effects were observed, supporting the safety of TOMAVAC. TOMAVAC should be a cost-effective, ecologically friendly, and widely-applicable novel-generation COVID-19 vaccine, providing two-layered protection against SARS-CoV-2.
Toxicity of natural and organic insecticidal products to greenhouse whitefly, Trialeurodes vaporariorum (Westwood) (Aleyrodidae: Hemiptera)
Authors: Kumari Shalika , Sood A.K. , Sharma P.K.
Published: January 2023

Lethal toxicity of six natural and organic insecticidal products namely, Darekastra, Dashparni, fermented buttermilk, fermented cow urine, Tamarlassi and vermiwash to second instar nymphs of greenhouse whitefly, Trialeurodes vaporariorum was evaluated using leaf dip method of bioassay. The insecticidal products evaluated at six concentrations ranging from 1.25 to 40.00% proved to be progressively more lethal to second instar nymphs with an increase in concentration resulting in mortality varying from 1.67 to 7.33% and 43.33 to 62.96 at concentrations of 1.25 and 40.00%, respectively. Tamarlassi proved most toxic against the nymphs. The order of toxicity was Tamarlassi = fermented buttermilk ≥ fermented cow urine ≥ Dashparni ≥ Darekastra ≥ vermiwash.
Tax, investment, institutional and social channels of economic shadowing: Challenges for macro-financial stability and good governance
Authors: Lyeonov Serhiy , Tiutiunyk Inna , Vasekova Miroslava , Oleksandr Dziubenko  , Samchyk Maksym
Published: January 2023

A significant size of the shadow economy is a threat to the sustainable functioning of a country’s economy, its ability to finance economic and social programs. The paper studies the influence of the shadow economy on the macro-financial stability of the EU countries. The dependence between macro-financial stability and the size of the shadow economy was estimated using the quadrocentric (considering the four channels of the shadow economy) recursive (takes into account direct and inverse relationships between them) model. Dependence between indicators was analyzed using Euler’s methods, Calvo’s and Dixit Stiglitz’s principles, Taylor’s and Smets-Wouters’ function. It has been proved that shadow economy channels affect the macro-financial stability almost equally (an increase in the size of the shadow economy in Slovenia by 1% leads to a decrease in macro-financial stability by 0.562% for tax, 0.56% for investment, 0.572 for institutional, and 0.444 for social channels). At the same time, the growth in the volume of shadow transactions through one channel forms an impetus for the increasing intensity of use of the remaining channels to hide income. With the help of the payment matrix, the optimal level of drivers of shadow economy by which the targeted value of the level of macro-financial stability is achieved was determined. It was concluded that ensuring good governance in the direction of preventing shadow schemes of capital withdrawal should be carried out in terms of institutional, tax, social, and investment channels of the shadow economy.
AcknowledgmentThis work was supported by the Slovak Research and Development Agency under the contract No. APVV-16-0602.
El olvido de la 'sophia'
Authors: Jaffelin Emmanuel
Published: January 2023

The philosophy is a discipline that is not a science and that is unfamiliar to the general public who sees in it a form of original reflection. To understand this originality,you have to remember of the beginning of the history of philosophy which, from the end of Antiquity, gave up his first goal, namely wisdom. From Emperor Justinian who closed all schools of philosophy in 533 AD, philosophy has survived while remaining a discourse (logos) disconnected from its action ; However, this action was sophia (wisdom). Consider then that Philosophy has been dead for 15 centuries and that the philosophers have survived by submitting to the authority in place, first to Theocracy and therefore to the Church, then to the State and therefore to Public Education. In the first case, philosophers are more interested in Faith and Holiness than in meditation and wisdom ; in the second case, they prefer to teach and write rather than dialogue to develop a peaceful way of life. Philosophy has strayed from it’s goal – Wisdom. It is therefore a question of reviving Philosophy by reopening schools which teach a wisdom
La acción moralmente buena en la ética de D. von Hildebrand
Authors: Beltrán Domínguez David
Published: January 2023

En el contexto de la ética fenomenológica de Dietrich von Hildebrand, indagamos sobre las vivencias implicadas en la acción moral y en las condiciones, tanto formales como materiales, que la constituyen en una acción moralmente buena o valiosa. En este análisis planteamos que en toda acción humana están presentes tres vivencias intencionales, a saber, la aprehensión cognoscitiva del valor, la respuesta al valor y la realización de la acción; y que el valor moral de una acción depende, principalmente, de la respuesta volitiva a un grupo especial de valores, los valores moralmente relevantes. Junto con ello, recuperamos el rol central del modelo o ejemplo moral en la educación valórica de las personas y la importancia de la imitación en el desarrollo moral de estas. Para ello, contraponemos la ética de Hildebrand a la ética kantiana. Además, reflexionamos sobre el sentido y alcance de la teoría de Hildebrand sobre las acciones inmorales, concluyendo que una acción formalmente moral (correcta) puede ser materialmente inmoral.
La crítica de Simondon al antropocentrismo moderno
Authors: Angulo Pablo
Published: January 2023

El presente ensayo resume la crítica del filósofo Gilbert Simondon al antropocentrismo moderno y a las concepciones sobre la técnica desarrolladas en el siglo XX por ciertas corrientes filosóficas que provienen, según él, de lo que denomina un humanismo fácil, que circunscriben el desarrollo técnico a la racionalidad instrumental y a la distinción entre medios y fines. La propuesta de Simondon para salir del marco de estas visiones que considera reduccionistas, es ampliar nuestra mirada sobre la técnica, no centrarnos en la relación entre medios y fines y adentrarnos en el conocimiento sobre los modos de existencia de los objetos técnicos. La mirada de Simondon nos invita a repensar nuestra relación con la técnica y, más allá incluso, a revisar nuestras concepciones ontológicas inclinándose por las que hoy conocemos como ontologías relacionales. La técnica para el filósofo francés es un puente entre nuestro pasado ritual y nuestra actualidad que persiste en la co-existencia de todos los seres, vivos y no vivos que conforman el tecno ecosistema.
A Novel Switched Hybrid-Voltage Doubler High Gain DC-DC Converter
for Renewable Energy Applications
Authors: Siva Asapu , Vanitha Rajendran
Published: January 2023

Background:

In renewable energy system applications, the power converter is essential
for transferring energy into the load centre. The AC network voltage is much higher than the renewable
energy source voltage; therefore, a transformer is commonly used to step up the voltage. However,
the size and cost of the system are larger due to the presence of a bulky transformer, and also
the efficiency is deteriorated due to PWM voltage being applied to the transformer.

Objective:

To eliminate the requirement of the transformer, DC link voltage is boosted up to a higher
level using a high-gain converter. Various DC-DC converters have been proposed in recent studies;
however, the involvement of the active switches is high to produce higher voltage gain, which
reduces efficiency. In order to overcome this limitation, this particular paper proposes a novel
switched hybrid-voltage doubler high gain DC-DC converter, which helps to achieve higher gain
with a minimum number of components count compared to other reported converters. It also reduces
the device's stress, thereby increasing its efficiency.

Method:

This paper describes the detailed operational studies along with CCM and DCM modes.
The mathematical analysis under each operating state is reported in this paper. A detailed comparative
study on the performance merits of the proposed converter, along with other recently reported
converters, is presented.

Results:

Finally, the simulation results are presented to validate the operation of the proposed converter.
Furthermore, a 500 W laboratory setup is developed to verify the operation details and practical
feasibility of the converter through experimental results and presented in this paper.

Conclusion:

From the measured results, it is concluded that the proposed converter can play the
most promising role in the transmission phase in renewable energy system implementations since it
boosts the voltage to the adequate point as required by the system.
O Cipriano Barata e Frei Caneca no Correio do Rio de Janeiro (1823): a disseminação do republicanismo cívico na Corte
Authors: Ferreira Paula Botafogo Caricchio
Published: January 2023

Based on the concepts of modernity of the public space,of liberal exileand Hispanic American experience, the present article intends to examine Cipriano Barata's and Frei Caneca's transcripts in Correio do Rio de Janeiro,in 1823, while its editor João Soares Lisboa was in prison for beingaccused of “colluding with Republicans”. These editions discussed civic virtues, the Emperor's morality, and the idealization of what Soares Lisboa called a “Monarchical-Democratic” government and disseminated, in the Court, the ruling centerof the Empire, a project forBrazil that foughtthe Upper House and defended provincial autonomy in a federal arrangement, with broad citizen participation in government, formation of militias and restrictionofthe monarch’s powers.
educación en línea como oportunidad de desarrollo profesional en personas vulnerables de la ciudad de Guayaquil
Authors: Alcívar Alcívar Ana María , Rengifo Suco Danna , Rivera Zambrano Cristina , Larrea Paredes Mónica
Published: January 2023

El cambio constante en el estilo de vida de las personas, permite que la educación en línea sea considerada como una opción viable y flexible para quienes por diversas circunstancias no pueden asistir físicamente a la universidad y encuentran en esta modalidad, una oportunidad de crecimiento profesional, esta es la principal motivación que lleva a las personas a tomar la decisión de iniciar o continuar sus estudios, sin embargo, considerando que la educación en línea registra mayor probabilidad de abandono, es importante conocer los factores intrínsecos y extrínsecos que influyen en la motivación de los estudiantes para lograr esa oportunidad de desarrollo profesional que buscan. Para realizar el levantamiento de datos, se aplicó una encuesta a 260 estudiantes que forman parte de un programa de becas en una institución de educación superior de la ciudad de Guayaquil, el principal objetivo fue conocer los factores motivacionales que sustentan la elección de la modalidad en línea como oportunidad de desarrollo profesional. Una vez obtenidos los resultados, se clasificó la información logrando establecer tres categorías de motivaciones en los ámbitos: personal, familiar y laboral, además los resultados permitieron identificar las dificultades personales, sociales y tecnológicas que deben superar para alcanzar su objetivo.
Desafíos sociales y tecnológicos en la pandemia y pospandemia: implementación de tecnología educativa en el proceso de vinculación con la sociedad de la Universidad ECOTEC 2020-2021
Authors: González Palma Karem , Henriques Aguilera Viviana
Published: January 2023

La vinculación con la sociedad es un eje integrador, que acompaña a la investigación y la academia en el modelo educativo de las Instituciones de Educación Superior del Ecuador. Este proceso ha sido concebido para su ejecución en modalidad presencial, atendiendo las necesidades y resolviendo las problemáticas de los grupos vulnerables en el entorno de la institución. Debido a la actual pandemia por Covid-19, la movilización y acción en territorio, se convierten en un desafío social. Por ello, se plantea la implementación de tecnología educativa para el desarrollo del proceso de vinculación con la sociedad en la Universidad ECOTEC. Para ello se integrarán los componentes de: adaptación de normativa, alineación teórica e implementación de tecnología educativa. Como mecanismo de validación, se presentará la medición de nivel de satisfacción de los estudiantes que fueron parte del proceso.
Incidencia de la publicidad en redes sociales de las instituciones de educación superior: revisión de literatura
Authors: Gallegos Erazo Franklin , Gavilanes Gómez Henrry
Published: January 2023

El presente trabajo de investigación buscó responder la pregunta de investigación ¿Cuál es la incidencia de la publicidad en las redes sociales de las Instituciones de Educación Superior (IES)? a través de una revisión de literatura en las bases de datos académicas Latindex, Scielo y Google Scholar respecto a los últimos estudios sobre la temática abordada. Los resultados más relevantes indican que los factores internos de las IES como lo son el servicio al cliente, atención, la calidad del servicio, educación y vida laboral, responsabilidad social y su gestión de contenidos en redes sociales, influyen en la percepción de los usuarios en redes sociales, proyectando así una imagen y reputación digital que afecta a su posicionamiento de de marca y por ende en la captación de nuevos clientes. Los comentarios y opiniones realizados por usuarios en las redes sociales se podrían considerar como el principal factor de influencia en la publicidad porque de tal manera influye a la decisión del usuario, ya que más allá de las estrategias de publicidad propias de cada institución se desarrollan; los usuarios no tienen una apropiación total de mensajes con los que se busca comercializar el servicio de las IES, sino que, es la experiencia de otros consumidores lo que hace creíble de la calidad demostrada y atributo de cada una de ellas.
Cultura Emprendedora: ¿Una estrategia para impulsar el desarrollo rural?
Authors: Ochoa Rico María Salomé , Concha Bucaram Andrés , Romero Subia José Fernando , Garnica Jarrín Lisette
Published: January 2023

En un mundo globalizado, donde las economías de los países interactúan entre sí, la cultura emprendedora constituye una oportunidad para crear ventaja competitiva. Hablar de emprendimiento como alternativa de desarrollo social en los sectores rurales nos lleva a cuestionar la conveniencia de su aplicabilidad, por sus características convencionales enfocadas en la acumulación de riqueza y en la irresponsable extracción de recursos. Superando esas ideas de emprendimiento convencional, es posible dirigir esfuerzos hacia la búsqueda del desarrollo rural implementando procesos innovadores y sostenibles que sumen a las múltiples dimensiones del desarrollo rural con enfoque territorial. Esta investigación plantea la hipótesis de la inexistencia de cultura emprendedora en la Comarca de Antequera – España, por lo que propone un estudio de caso prospectivo, efectuado con la participación de informantes claves, quienes identificaron las variables claves alrededor de la problemática propuesta. En la primera etapa del análisis se caracterizaron las variables claves, en la segunda fase, se estableció la relación entre variables en una matriz de relaciones directas, a partir de un análisis cualitativo por cada pareja de variables, se determina el nivel de relación de influencia directa. Aplicando la herramienta de reflexión colectiva MICMAC, se obtienen las matrices de relación directa, indirecta y potenciales, presentando las variables claves en forma estructurada y jerárquica en términos de influencia y dependencia. Los resultados sugieren que las variables de conflicto, sobre las que se debe tomar acción son: Necesidad de Endeudamiento, escasa implementación de procesos tecnológicos y crisis económica.
Acknowledgment to Reviewers of Journal of Energy and Power Technology in 2022
Authors: Editorial Office Journal of Energy and Power Technology
Published: January 2023

The editors of Journal of Energy and Power Technology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2022. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.
Promoting Advance Care Planning for Persons with Dementia: Study Protocol for the LEAD (Life-Planning in Early Alzheimer’s and Other Dementias) Clinical Trial
Authors: Dassel Kara , Iacob Eli , Utz Rebecca , Supiano Katherine , Furhmann Hollie
Published: January 2023

Due to the insidious progression of Alzheimer's disease and related dementias (ADRD), surrogate decision-makers typically make medical and long-term-care decisions for a care recipient, most often a family care partner. Unfortunately, many care recipient/care partner dyads have failed to engage in advance care planning or have lost the opportunity to do so due to the cognitive decline of the care recipient. To address this need, our team created a validated dementia-focused advance care planning tool known as the LEAD Guide (Life-Planning in Early Alzheimer’s and Other Dementias). With funding from the National Alzheimer's Association and in consultation with our community advisory board, we developed a preliminary web-based intervention. This intervention integrates the LEAD Guide with self-paced educational modules that lead dyads through conversations and dementia-focused advance care planning processes. In this concept paper, we describe the aims of our funded R01 clinical trial (National Institute on Aging), where we aim to refine our preliminary web-based platform for use in a 5-month mixed-method NIH Stage-1 behavioral intervention. Using a sample of diverse community-based ADRD dyads (n = 60), we aim to: 1) describe the acceptability, usability, and feasibility of the intervention, 2) assess the initial efficacy of the intervention on the primary outcome (decision-making self-efficacy), and secondary outcomes (relationship quality, subjective well-being, anxiety) as perceived by both the care recipient and the care partner, and 3) examine advance care planning congruence as a mechanism of action. The LEAD clinical trial addresses public health challenges by guiding and supporting families through challenging advance care planning conversations, facilitating the transfer of knowledge regarding care preferences and values from the care recipient to the care partner, with the ultimate goal of improving the quality of life for both individuals with ADRD and their care partners.
Acknowledgment to Reviewers of OBM Neurobiology in 2022
Authors: Editorial Office OBM Neurobiology
Published: January 2023

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2022. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the service Publons (https://publons.com) to receive recognition. Of course, in these initiatives we are careful not to compromise reviewer confidentiality. Many reviewers see their work as a voluntary and often unseen part of their role as researchers. We are grateful to the time reviewers donate to our journals and the contribution they make.
Factors Affecting the Successful Implementation of a Digital Intervention for Health Financing in a Low-Resource Setting at Scale: Semistructured Interview Study With Health Care Workers and Management Staff
Authors: Schuetze Leon , Srivastava Siddharth , Missenye Abdallah Mtiba , Rwezaula Elizeus Josephat , Stoermer Manfred , De Allegri Manuela
Published: January 2023

Background

Digital interventions for health financing, if implemented at scale, have the potential to improve health system performance by reducing transaction costs and improving data-driven decision-making. However, many interventions never reach sustainability, and evidence on success factors for scale is scarce. The Insurance Management Information System (IMIS) is a digital intervention for health financing, designed to manage an insurance scheme and already implemented on a national scale in Tanzania. A previous study found that the IMIS claim function was poorly adopted by health care workers (HCWs), questioning its potential to enable strategic purchasing and succeed at scale.

Objective

This study aimed to understand why the adoption of the IMIS claim function by HCWs remained low in Tanzania and to assess implications for use at scale.

Methods

We conducted 21 semistructured interviews with HCWs and management staff in 4 districts where IMIS was first implemented. We sampled respondents by using a maximum variation strategy. We used the framework method for data analysis, applying a combination of inductive and deductive coding to organize codes in a socioecological model. Finally, we related emerging themes to a framework for digital health interventions for scale.

Results

Respondents appreciated IMIS’s intrinsic software characteristics and technical factors and acknowledged IMIS as a valuable tool to simplify claim management. Human factors, extrinsic ecosystem, and health care ecosystem were considered as barriers to widespread adoption.

Conclusions

Digital interventions for health financing, such as IMIS, may have the potential for scale if careful consideration is given to the environment in which they are placed. Without a sustainable health financing environment, sufficient infrastructure, and human capacity, they cannot unfold their full potential to improve health financing functions and ultimately contribute to universal health coverage.
Addictive Potential of e-Cigarettes as Reported in e-Cigarette Online Forums: Netnographic Analysis of Subjective Experiences
Authors: Szafran Daria , Görig Tatiana , Vollstädt-Klein Sabine , Grundinger Nadja , Mons Ute , Lohner Valerie , Schneider Sven , Andreas Marike
Published: January 2023

Background

While e-cigarettes usually contain nicotine, their addictive potential is not yet fully understood. We hypothesized that if e-cigarettes are addictive, users will experience typical symptoms of addiction.

Objective

The aim of our study was to investigate whether and how e-cigarette users report signs of addiction.

Methods

We identified 3 large German-language e-cigarette online forums via a systematic Google search. Based on a netnographic approach, we used deductive content analysis to investigate relevant posts in these forums. Netnography has the advantage of limiting the social desirability bias that prevails in face-to-face research, such as focus groups. The data were coded according to the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for tobacco use disorder, adapted for e-cigarettes. The DSM-5 criteria were used to portray a broad spectrum of possible experiences of addiction.

Results

Overall, 5337 threads in 3 forums were screened, and 451 threads containing relevant information were included in the analysis. Users reported experiences consistent with the DSM-5 criteria, such as craving e-cigarettes, excessive time spent vaping, and health issues related to e-cigarette use. However, our analysis also showed that users reported the absence of typical tobacco use disorder criteria, such as successful attempts to reduce the nicotine dosage. For most themes, reports of their absence were more frequent than of their presence. The absence of perceived addiction was mostly reported in contrast to prior tobacco smoking.

Conclusions

This is the first study to use a netnographic approach to explore unfiltered self-reports of experiences of e-cigarette addiction by users in online forums. As hypothesized, some but not all users reported subjective experiences that corresponded to the criteria of tobacco use disorder as defined by the DSM-5. Nevertheless, subjective reports also indicated that many e-cigarette users felt in control of their behavior, especially in contrast to their prior use of tobacco cigarettes. The finding that some e-cigarette users subjectively experience addiction highlights the need for effective cessation programs to support users who experience their e-cigarette use as burdensome. This research can guide the refinement of instruments to assess e-cigarette addiction and guide cessation programs.

International Registered Report Identifier (IRRID)

RR2-10.1186/s40359-021-00682-8
The Environmental and Socioeconomic Effects and Prediction of Patients With Tuberculosis in Different Age Groups in Southwest China: A Population-Based Study (Preprint)
Authors: Wei Wen , Xia Lan , Wu Jianlin , Zhou Zonglei , Zhang Wenqiang , Luan Rongsheng
Published: January 2023

BACKGROUND

While the End Tuberculosis (TB) Strategy has been implemented worldwide, the cause of the TB epidemic is multifactorial and not fully understood.

OBJECTIVE

This study aims to investigate the risk factors of TB and incorporate these factors to forecast the incidence of TB infection across different age groups in Sichuan, China.

METHODS

Correlation and linear regression analyses were conducted to assess the relationships between TB cases and ecological factors, including environmental, economic, and social factors, in Sichuan Province from 2006 to 2017. The transfer function-noise model was used to forecast trends, considering both time and multifactor effects.

RESULTS

From 2006 to 2017, Sichuan Province had a reported cumulative incidence rate of 1321.08 cases per 100,000 individuals in male patients and 583.04 cases per 100,000 individuals in female patients. There were significant sex differences in the distribution of cases among age groups (trend χ225=12,544.4; P<.001). Ganzi Tibetan Autonomous Prefecture had the highest incidence rates of TB in both male and female patients in Sichuan. Correlation and regression analyses showed that the total illiteracy rate and average pressure at each measuring station (for individuals aged 15-24 years) were risk factors for TB. The protective factors were as follows: the number of families with the minimum living standard guarantee in urban areas, the average wind speed, the number of discharged patients with invasive TB, the number of people with the minimum living standard guarantee in rural areas, the total health expenditure as a percentage of regional gross domestic product, and being a single male individual (for those aged 0-14 years); the number of hospitals and number of health workers in infectious disease hospitals (for individuals aged 25-64 years); and the amount of daily morning and evening exercise, the number of people with the urban minimum living standard guarantee, and being married (for female individuals aged ≥65 years). The transfer function-noise model indicated that the incidence of TB in male patients aged 0-14 and 15-24 years will continue to increase, and the incidence of TB in female patients aged 0-14 and ≥65 years will continue to increase rapidly in Sichuan by 2035.

CONCLUSIONS

The End TB Strategy in Sichuan should consider environmental, educational, medical, social, personal, and other conditions, and further substantial efforts are needed especially for male patients aged 0-24 years, female patients aged 0-14 years, and female patients older than 64 years.
Stevens-Johnson Syndrome in Adult Patient Secondary to COVID-19 Infection: Case Report (Preprint)
Authors: Khade Pandharinath , Shah Avani , Kharkar Vidya
Published: January 2023

UNSTRUCTURED

COVID-19 is a global pandemic caused by a novel zoonotic RNA virus named SARS-CoV-2. Various cutaneous manifestations associated with COVID-19 have been described, including urticarial rash, confluent erythematous rash, papulovesicular exanthem, chilblain-like acral pattern, livedo reticularis, and purpuric vasculitis pattern. Here, we are presenting a case of a 45-year-old male with mucocutaneous features of Stevens-Johnson syndrome.
La edad de los comerciantes y el panorama ante el covid-19: caso Jerez, Zacatecas
Authors: Villegas-Berumen Héctor , Nuñez-Orta María de la Luz , Reveles-Gamboa Susana
Published: January 2023

El objetivo de esta investigación es mostrar los resultados obtenidos de la correlación entre la edad de los comerciantes, la innovación implementada en sus modelos de negocio y los efectos económicos que trajo consigo la crisis sanitaria por covid-19 en el municipio de Jerez, Zacatecas. Se encontró que la innovación es proporcionalmente inversa a la edad de los comerciantes y que la edad del comerciante condiciona en cierto grado la permanencia de su negocio ante la pandemia, así como que las personas de mayor edad son más vulnerables a una crisis económica frente al covid-19.
Justicia ambiental urbana: luces y sombras en el ordenamiento jurídico mexicano
Authors: Tristán Rodríguez María Suhey , Revuelta Vaquero Benjamín
Published: January 2023

El artículo analiza la justicia ambiental urbana como un nuevo y esperanzador paradigma en México; aun cuando no se reconoce expresamente en nuestro país, existen principios y previsiones en la Constitución Política, en los tratados internacionales, en diversas leyes nacionales y en resoluciones jurisdiccionales que lo sustentan. Con este marco, el artículo construye un análisis crítico sobre las fortalezas y debilidades actuales de la justicia ambiental urbana. El ejercicio de identificar luces y sombras permite el posicionamiento del tema, así como visualizar las tendencias deseables pre y post, es decir, la planeación y la reivindicación.
Legal Education – An analysis of the teacher / student Relationship in the teaching Learning Process
Authors: Silva Manuel Gomes da , Tassigny Monica Mota
Published: January 2023

With the COVID-19 pandemic, the teacher-student relationship faces the challenge of giving new meaning to the teaching-learning process. Thus, it isproposed to analyze the pedagogical mediation as a strategy capable of favoring the teaching-learning processes in Law, in times of complexity. The teacher-student relationship should favor the student's curiosity and creativity in an environment that favors the perception of meanings and senses. It is a bibliographic and documentary, qualitative and exploratory research. It appears that the teacher-mediator must validate previously obtained knowledge and favor collaborative processes, which encourage critical thinking in the student and favor the development of their protagonism.
Immediate Load in Units using the Indexed Prosthesis in the Sensitive System
Authors: Júnior Jenival C de Almeida , Neves Emilli L , Almeida Gustavo M de
Published: January 2023

This clinical case report emphasizes the significant variations in implant placement systems, which denotes an emerging need for systems that minimize deviations in order to ensure implant placement at the intended bone level. The present work suggests a protocol for a simplified indexing technique using the Index Sensitive® technology (Conexão Sistema de Prothesis, São Paulo, Brazil), with the immediate placement of an implant-supported prosthesis with an indexed abutment in the implant, minimizing errors and distortions in the final result. of surgery arising from the process of making the surgical guide and the surgical procedure. The objective of this case report was to prove the efficiency of the Sleeve Index Sensitive® system in the manufacture of implant-supported prostheses in exoplan and dentalcad software prior to implant installation and to assess whether the transfer of the planning in the software to the patient's mouth is accurate. Alternative hypothesis that the Sleeve Index Sensitive® system is efficient in reproducing the indexed schedule and preserves the natural emergence profile. Patients were included with root fractures, and after previous analysis, it was proposed and the installation of dental implants of immediate loading in single units using the prosthesis indexed in the Sensitive® System. The data needed for indexing was imported into the Exoplan software, Exocad. Surgical planning was performed with the prosthetic component, Ti-Base S NP, virtually indexing the prosthesis, determining the positioning of the tooth to the implant, generating the surgical guide. The surgical guide has been incorporated into Sensitive® ferrules with a lock in a single position. Then it was exported in an STL file to be printed. The surgical plan was exported to manufacture the prosthesis. With the printed guide, milling was performed to install the Flash Vulcano implant with a diameter of 3.5 mm and height variation according to each case, distinctly.
Factors associated with anxiety and depression in intensive care unit professionals: An integrative review
Authors: Oliveira Ana Emília Araújo de , Sousa Sandyla Leite de , Queiroz Joyce Helena Leão , Pinheiro Romulo Ayres Dias , Bringel Isadora Luísa Borges , da Silva Julianne de Area Leão Pereira , Dias Rômulo Soares , Rocha Jamile Sales , Ribas Sarah Lima Fernandes , Araujo Gabriel Gardhel Costa
Published: January 2023

Intensive Care Units are units that provide intensive care to patients who need continuous observation, critically ill or hemodynamically unstable. Workers' mental health has been the target of stressors in this pandemic due to psychological overload, fatigue, exposure to large-scale deaths and significant losses, frustrations related to the quality of care, threats, aggression and increased risk of infection. Generalized Anxiety Disorder is characterized by excessive anxiety and worry about a variety of activities or events. In parallel, Depressive Disorder is characterized by severe or persistent sadness to the point of interfering with functioning and, often, decreasing interest or pleasure in the bearer's daily activities. This study is an integrative literature review (RIL) that is based on scientific findings with the objective of identifying and understanding problems, situations and vulnerabilities related to the population. The studies were published in the years 2020, 2021 and 2022, being the equivalent of 22.22% in the year 2020, 55.55% in the year 2021 and about 22.22% in the year 2022. Were respectively from Norway, Turkey, Brazil, Spain, United States of America, France, China and Italy, with France being the country with the highest prevalence in the study, presenting about 22.22% of the total percentage and the other countries containing only 11, 11%. Therefore, the contents of the research found referred to the factors associated with anxiety and depression in professionals in intensive care units: an integrative review.
Analysis of the Compatibility of the Exclusive Taxation Regime applicable in the Financial and Capital Markets and the Principle of the Economic Capacity
Authors: Nagib Luiza
Published: January 2023

Brazilian Constitution is the keystone for all Brazilian tax system. All other rules derive and are severely influenced by the Constitution. Non-compliance with the Principles set forth in the Constitution leads to unconstitutionality. Concerning Income Taxes, Brazilian Constitution provides that it must observe the “Economic Capacity” of the taxpayers and that it must be Progressive. This means that the applicable tax rate should be progressively higher as the tax calculation basis is increased. This is precisely what occurs with income derived from employment, as taxpayers are subject to a progressive taxation rate, ranging from 0% to 27,5%, depending on the economic capacity. However, when it comes to fixed income assets and variable income assets available in the financial and capital market, the taxation regime has specific rules that are often more advantageous in comparison with the income derived from employment relations or that adopt other criteria rather than the economic capacity. As per example, an investor accruing a large sum of money in a Certificate of Bank Deposit may be taxed at a 15% rate, a significant lower rate in comparison with the aforementioned 27,5% applicable to employment income. Hence, in principle, taxation in financial and capital markets seems to be incompatible with the Principle of Economic Capacity and Progressive Taxation. The purpose of our article is to study weather or not the taxation of financial and capital market instruments is compatible with the Constitution, notably in face of those two Principles or if, given the relevance in the economy of such instruments, such taxation could be accepted.
A plain language summary of the impact of vaccines against flu and chickenpox in people with multiple sclerosis treated with cladribine tablets
Authors: Schmierer Klaus
Published: January 2023

This video is based on a plain language summary of publication published in Neurodegenerative Disease Management. The publication looks into the effect of cladribine on vaccines in people with multiple sclerosis.
Cladribine tablets work by temporarily reducing the number of lymphocytes, which are immune cells that help to fight off infections. Because of this, people with multiple sclerosis (also called PwMS) may have concerns about the effect of cladribine tablets on vaccines, as these work via immune cells to build protection against infection.
The original study was called MAGNIFY-MS, and investigated how long it takes for cladribine tablets to begin to work in people with a type of MS called highly active relapsing MS.
The MAGNIFY-MS study gave the researchers an opportunity to look at how cladribine tablets affect the way the flu and chickenpox virus vaccines work in the body.
Effect of Different Irrigation Patterns on Oat-Vetch Mixed Forage Production System in Rasuwa, Mid Hills of Nepal
Authors: Dhakal Bhojan , Poudel Nabaraj , Shah Bimala
Published: January 2023

Abstract: The scarcity of forage resources, particularly in Nepal's midhills, poses a challenge to the sustainable development of livestock production. In order to address issues, an experiment was carried out in 2020 at Kalika Municipality in Rasuwa District, Nepal, to determine the best forage combinations in terms of total dry matter productivity. With irrigation as a main plot effect, a 4*3 factorial RCB design was used with four replications. Crop species included oat (Avena sativa, Kamdhenu), common vetch (Vicia sativa), and combinations of oat and vetch within a sub plot. Irrigation treatments included none, once per month (30-day interval), twice per month (15-day interval), and three times per month (10-day interval). Temperature and precipitation data from nearby stations were taken from the Department of Hydrology and Meteorology. The first harvest was taken after 65 days of sowing (DAS), with consecutive harvests after 35 days of the initial harvest. The experimental findings revealed that the first, second, and total dry matter production were altogether found highest in the three times irrigated plot (2.47±0.25, 1.38±0.21, 3.85±0.46 respectively) and lowest in the rainfed condition (1.37±0.22, 0.69±0.12, 2.07±0.33 ton/ha respectively) with statistically highly significant result (p<0.001). The oat and vetch mixed cropping pattern had statistically higher dry matter production in the first (2.66 0.14 ton/ha), second (1.5 0.13 ton/ha), and overall average total production of (4.16 0.25 ton/ha), among the subplot effect (species). Additionally, among the subplot effects, the oat and vetch mixed cropping had the highest dry matter production in terms of first harvest yield, regrowth, and overall yield (p<0.01). Oat sole cropping could be replaced with mixed cropping of oat and vetch at a ratio of 50:50 (50:10 kg ha-1) because it produced the highest yield advantage, including forage quality. These findings provide scientific support for common vetch-oat intercropping as a sustainable approach to increase forage production with 10-day irrigation interval. These mixtures appear promising for the development of sustainable crop production with low external input and higher economic yield, and they can be used as a viable option by farmers in rainfed mid-hills of Nepal
A Study to Assess the Level Knowledge Regarding Menstrual Hygiene Among Adolescent Girls in Selected School at Meerut, U.P
Authors: Mathew Ms. Blessy , Tyagi Ms. Shiva , Vidhushi Ms. , Mohit Mr. , Gaurav Mr. , Peter Ekta , Kumar Mr. Amit , Sharma Mr. Laxmikant
Published: January 2023

Abstract: Statement Of Problem: “A study to assess the level knowledge regarding menstrual hygiene amongadolescent girls in selected school at Meerut, U.P” Objectives: To assess the level knowledge among adolescent girls regarding MenstrualHygiene. To determine the association between the Menstrual Hygiene amongadolescent girls with selected demographic variables. Methodology: A Quantitative research approach and descriptive research design was used in this study. Sample size comprised of 30 adolescent girls and the sample was selected by convenient sampling technique. Self-structured questionnaire used to collect the data. The gathered data was analyzed using descriptive and inferential statistics. Result: The findings show that out of 30 samples 14(46.7%) were having inadequate knowledge, 10(33.3%) were having moderate and 06(20%) were having adequate knowledge. The chi – square test shows that there was a significant association betweenLevels of knowledge regarding Menstrual Hygiene among the age and level of education of individual Conclusion: The study revealed that adolescent girls having inadequate knowledge regarding Menstrual Hygiene. There was significant association between Level of knowledge score of adolescent girls with age and level of education.
The Implementation of the Going Concern Principle in Bankruptcy and The Suspension of Payment to Protect the Economic Rights of the Parties
Authors: Gultom Elisatris , Disyon Huta
Published: January 2023

This study aims to analyze the regulation on the going concern principle and indicators to determine the continuity of prospective business activity. It employed normative juridical method that was based on library research. It obtained secondary data sourced from primary, secondary, and tertiary legal materials. The study was analytical descriptive because the author described the going concern principle by referring to the Law Number 37 of 2004 on Bankruptcy and Suspension of Debt Payment Obligations (the Bankruptcy Law). subsequently, the study analyzed it to find relevant indicators to determine whether a prospective business activity can continue or not. The data were analyzed using a qualitative juridical method. The results indicate that the sustainability of the debtor’s business is crucial for the fulfillment of the economic rights of the debtor and creditor, even though the law does not provide indicators to determine that the prospective debtor’s business will continue. For this reason, decisions regarding the business continuity of debtors are influenced by various internal and external factors and must be made by competent parties.
The Protection of Spiritual Rights in the Sharia Banking Dispute Settlement: Overview of the Sharia Banking Law in Indonesia
Authors: Bustamin Amirizal , Azka Muthia Arini , Ivana Barus Sonia
Published: January 2023

The status of Islamic banking in dispute settlement is normatively a positive legal subject to Islamic law principles. The Financial Services Authority confirms that many conflicts involve Islamic banks and their customers. The problem of the legal and economic context of Islamic banking is more complex, considering the operational concept of Islamic banks is different from conventional banking. Islamic banking must operate based on sharia, including in dispute resolution issues. Spiritual rights are one of the interests of Islamic banking customers that require attention. This study investigates the protection of spiritual rights in the sharia banking dispute settlement based on the perspective of Indonesian sharia banking law. This study employed normative qualitative research methods on primary data, such as the sharia banking law, the consumer protection act, and the dispute resolution act. It found that Indonesia has laws to address sharia banking disputes based on Islamic principles. However, they have not been appropriately implemented. The authority of religious courts to settle disputes on sharia banking has not been effective in protecting spiritual rights because there are still processes of settlement on sharia banking through the general courts. It indicates that stakeholders’ understanding of spiritual rights is still limited.
Philosophy of Mind: Introduction
Authors: Vasilyev Vadim V.
Published: January 2023

The introductory article by V.V. Vasilyev, the guest editor of the thematic section on “Philosophy of Mind”, offers a general vision on the researches of mind and consciousness today, gives a brief overview of the articles presented in the issue, and outlines the horizon for the development of both interdisciplinary and philosophical studies of consciousness.
Activities of the student association as a contribution to the development of professional skills of students and the beginning of scientific research
Authors: Aleinikova Anna M.
Published: January 2023

In 2022, the Professional Student Society of the RUDN University Ecology Institute turned 10 years old. The Society has made a significant contribution to the environmental education of many generations of environmental students. Many interesting expeditions, volunteer work, quests, round tables, reports were organized. Based on the results of field work, scientific articles and graduation papers were written, agreements were signed with national parks.