bluuebunny/crossref_metadata_2025 huggingface dataset:
Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine
Authors: Bergonzini Marcello , Loreni Francesco , Lio Antonio , Russo Marco , Saitto Guglielmo , Cammardella Antonio , Irace Francesco , Tramontin Corrado , Chello Massimo , Lusini Mario , Nenna Antonio , Ferrisi Chiara , Ranocchi Federico , Musumeci Francesco
Published: October 2023

Epigenetic modifications play a fundamental role in the progression of coronary artery disease (CAD). This panoramic review aims to provide an overview of the current understanding of the epigenetic mechanisms involved in CAD pathogenesis and highlights the potential implications for personalized medicine approaches. Epigenetics is the study of heritable changes that do not influence alterations in the DNA sequence of the genome. It has been shown that epigenetic processes, including DNA/histone methylation, acetylation, and phosphorylation, play an important role. Additionally, miRNAs, lncRNAs, and circRNAs are also involved in epigenetics, regulating gene expression patterns in response to various environmental factors and lifestyle choices. In the context of CAD, epigenetic alterations contribute to the dysregulation of genes involved in inflammation, oxidative stress, lipid metabolism, and vascular function. These epigenetic changes can occur during early developmental stages and persist throughout life, predisposing individuals to an increased risk of CAD. Furthermore, in recent years, the concept of personalized medicine has gained significant attention. Personalized medicine aims to tailor medical interventions based on an individual’s unique genetic, epigenetic, environmental, and lifestyle factors. In the context of CAD, understanding the interplay between genetic variants and epigenetic modifications holds promise for the development of more precise diagnostic tools, risk stratification models, and targeted therapies. This review summarizes the current knowledge of epigenetic mechanisms in CAD and discusses the fundamental principles of personalized medicine.
A Novel Optical Fiber Terahertz Biosensor Based on Anti-Resonance for The Rapid and Nondestructive Detection of Tumor Cells
Authors: He Zhe , Luo Yueping , Huang Guorong , Lamy de la Chapelle Marc , Tian Huiyan , Xie Fengxin , Jin Weidong , Shi Jia , Yang Xiang , Fu Weiling
Published: October 2023

The sensitive and accurate detection of tumor cells is essential for successful cancer therapy and improving cancer survival rates. However, current tumor cell detection technologies have some limitations for clinical applications due to their complexity, low specificity, and high cost. Herein, we describe the design of a terahertz anti-resonance hollow core fiber (THz AR-HCF) biosensor that can be used for tumor cell detection. Through simulation and experimental comparisons, the low-loss property of the THz AR-HCF was verified, and the most suitable fiber out of multiple THz AR-HCFs was selected for biosensing applications. By measuring different cell numbers and different types of tumor cells, a good linear relationship between THz transmittance and the numbers of cells between 10 and 106 was found. Meanwhile, different types of tumor cells can be distinguished by comparing THz transmission spectra, indicating that the biosensor has high sensitivity and specificity for tumor cell detection. The biosensor only required a small amount of sample (as low as 100 μL), and it enables label-free and nondestructive quantitative detection. Our flow cytometry results showed that the cell viability was as high as 98.5 ± 0.26% after the whole assay process, and there was no statistically significant difference compared with the negative control. This study demonstrates that the proposed THz AR-HCF biosensor has great potential for the highly sensitive, label-free, and nondestructive detection of circulating tumor cells in clinical samples.
Tinnitus, Suicide, and Suicidal Ideation: A Scoping Review of Primary Research
Authors: MacDonald Carol , Caimino Charlotte , Burns-O’Connell Georgina , Hartley Douglas , Lockwood Joanna , Sereda Magdalena , Whitmer William , Cima Rilana , Turton Laura , Hoare Derek J.
Published: October 2023

Tinnitus (the perception of sound in the absence of any corresponding external source) is highly prevalent and can be distressing. There are unanswered questions about how tinnitus, suicidal thoughts, and suicidal behaviours co-occur and interact. To establish the extent of scientific literature, this scoping review catalogued primary reports addressing the associations between tinnitus, suicidal ideation, attempted suicide, and death by suicide. We searched OvidSP, Medline, EMBASE, PsycINFO, CINAHL, Google Scholar, EThoS, and ProQuest for all studies and case reports on ideation and/or attempted and/or completed suicide in the context of tinnitus. Twenty-three studies were included, and data were charted according to study type. Several epidemiological and other observational studies gave evidence of risk factors and an association between suicidal ideation, suicidal behaviour, and tinnitus. However, there was no evidence of the direction of causality. Qualitative studies are indicated to explore the patient’s experience and understand the dynamics of any interaction between tinnitus and suicidal thoughts and behaviours. A theory-informed model of tinnitus and suicide needs to be developed to inform the development of interventions and how tinnitus patients are supported clinically.
Path Model Analysis of the Effects of Perceived Formalism, and Fear of COVID-19 on Police Officers’ PTSD and Insomnia
Authors: Huang Frank Fu-Yuan , Liu Hsiang-Te
Published: October 2023

This study examines whether law enforcement officers’ fear of COVID-19, job burnout, and job stress have increased their PTSD and insomnia during the epidemic. This article introduces the perceived formalism of police agencies into the causal model to explore whether perceived formalism increases the job burnout and job stress of police officers. The formalism of administrative agencies is rarely included in epidemic research. This study collected 306 Taiwanese police officers as research subjects. We used confirmatory factor analysis and SEM for hypothesis testing. The study found that perceived formalism positively affects the job burnout and job stress of police officers. Job stress, fear of COVID-19, and job burnout positively affect PTSD and insomnia.
Socioeconomic Status and Students’ Mental Health during the COVID-19 University Closure: Mediating Roles of Perceived Social Support and Self-Efficacy
Authors: Huang Liang , Wang Dongsheng
Published: October 2023

Despite the need for urgent actions in response to the exacerbated inequalities in mental health resulting from the COVID-19 pandemic, there remains a significant gap in research into the relationships and underlying mechanisms between socioeconomic status (SES) and various mental health outcomes among students during the COVID-19 university closure. With a sample of 839 students from a university in Lanzhou, the capital city of China’s Gansu Province, which was closed during the 2022 autumn semester due to the COVID-19 outbreak, this study examined the relationships between SES and both the negative and positive mental health outcomes, with a particular inquiry into the mediating roles of perceived social support and self-efficacy. The results show that SES had significant and negative total associations with psychological distress (β = −0.119, p < 0.001) and loneliness (β = −0.132, p < 0.001), while having significant and positive total associations with life satisfaction (β = 0.90, p < 0.01) and affective well-being (β = 0.108, p < 0.01). Moreover, perceived social support and self-efficacy independently and sequentially mediated the associations between SES and various mental health outcomes. Research implications for the design and improvement of university measures to reduce the socioeconomic inequalities in students’ mental health are also discussed.
Understanding the Role of Parent‒Child Relationships in Conscientiousness and Neuroticism Development among Chinese Middle School Students: A Cross-Lagged Model
Authors: Cao Xiaojie , Liu Xinqiao
Published: October 2023

The parent‒child relationship is a crucial factor in promoting adolescent mental health. However, the current evidence on the relationship between parent‒child relationships and adolescent conscientiousness and neuroticism, as well as the directionality of these relationships, remains limited. In particular, there is a lack of analysis focusing on Chinese middle school students. Based on a sample of 8437 students from the China Education Panel Survey (CEPS) database, this study empirically examined the bidirectional relationships between parent‒child relationships, conscientiousness and neuroticism among Chinese middle school students, with specific emphasis on the significant role of parent‒child relationships in the development of conscientiousness and neuroticism. Descriptive statistical results indicated that during the seventh and eighth grades of Chinese middle school students, the closeness of their parent‒child relationships with both parents decreased, while the level of conscientiousness showed a slight decrease, and neuroticism showed an increasing trend. Correlational results demonstrated a significant positive correlation between parent‒child relationships and conscientiousness and a significant negative correlation between parent‒child relationships and neuroticism. Further analysis using cross-lagged models revealed that parent‒child relationships significantly positively predicted subsequent conscientiousness development, and conscientiousness significantly positively predicted subsequent parent‒child relationships. Parent‒child relationships significantly negatively predicted subsequent neuroticism development, and neuroticism levels also significantly negatively predicted subsequent parent‒child relationships. Based on these findings, we believe that there is a need to strengthen parent‒child relationships and to recognize the important role that both mothers and fathers play in the healthy development of their children. Both parents should actively contribute to their children’s upbringing and take responsibility for their family education.
Gas Pipeline Response to Underlying Straight-Wall Arch Tunnel Construction
Authors: Zhang Xu , Liang Chiyu , Huang Shimin , Xu Youjun
Published: October 2023

Straight-wall arch cross-sections are usually designed at the entrance and exit tunnels of subway stations, and dense underground pipelines often cross these cross-sections at close range. Among these pipelines, gas pipelines have the highest risk level. Therefore, it is necessary to reduce the deformation influence of underground crossing construction on existing gas pipelines. Based on the No. 2 entrance and exit tunnel project of Zhongshan Road Station of the Hohhot Metro Line 2, using the methods of numerical simulation and field monitoring, this paper has particularly investigated the influence of straight-wall arch tunnel construction by applying the pre-grouting reinforcement and double-side drift method to the deformation of existing gas pipelines. The research results show that the double-side drift method is an efficient and sustainable construction method for straight-wall arch tunnels, which can effectively reduce the crossing construction disturbance to overlying gas pipelines. The measured maximum settlement of the existing gas pipeline is 18.46 mm, and the maximum settlement of the new tunnel vault is 22.86 mm, with both values satisfying the requirements for deformation control. The simulation results are consistent with the measured results of gas pipeline settlement. This study shows that the safety control scheme employed in the field with a tunnel excavation step of 6 m, stratum reinforcement with upper semi-section grouting, and a grouting reinforcement range of 2.0 m is reasonable and effective. This scheme can provide a reference for the deformation control of similar underground gas pipelines in the crossing construction of straight-wall arch tunnels at close range.
How Toll-like Receptor 9 Plays a Key Role in the Development of Gastric Cancer and Is Linked to Epstein–Barr Virus Infection
Authors: Majewski Marek , Mertowska Paulina , Mertowski Sebastian , Torres Kamil , Grywalska Ewelina
Published: October 2023

The relationship between Toll-like receptor 9 (TLR-9) signaling and its involvement with Epstein–Barr virus (EBV) in gastric cancer (GC) is complex and currently under study. This research intended to understand TLR-9’s role in certain T and B lymphocytes and the serum levels of TLR-9 in GC patients versus healthy subjects. The team explored links between these immune markers and various GC traits, such as histological grade, tumor progression stages, cancer types, and survival rates. Additionally, the research sought to find if EBV genetic material influences these immune reactions. Using flow cytometry, TLR-9 levels in different immune cells were analyzed. At the same time, the amount of TLR-9 in the serum was determined. The results showed GC patients had varied TLR-9 levels compared to healthy subjects, with specific cells showing noticeable changes. When grouped by GC attributes, key relationships emerged between TLR-9 amounts, the histological grade, progression stages, and cancer types. A notable finding was the connection between TLR-9 levels and EBV genetic presence, suggesting possible interactions between TLR-9 responses and EBV-related GC processes. Survival data also hinted at TLR-9’s potential as a predictor linked to clinical traits. Overall, this research emphasizes TLR-9’s complex role in GC’s immune responses, pinpointing its interactions with particular cells, clinical features, and EBV. The study unveils a complex web affecting GC and paves the way for new treatment avenues targeting TLR-9 pathways.
Defining MRI Superiority over CT for Colorectal and Neuroendocrine Liver Metastases
Authors: Attiyeh Marc A. , Malhotra Gautam K. , Li Daneng , Manoukian Saro B. , Motarjem Pejman M. , Singh Gagandeep
Published: October 2023

Background: We compared CT and MRI for staging metastatic colorectal or neuroendocrine liver metastases (CRLMs and NELMs, respectively) to assess their impact on tumor burden. Methods: A prospectively maintained database was queried for patients who underwent both imaging modalities within 3 months, with two blinded radiologists (R1 and R2) independently assessing the images for liver lesions. To minimize recall bias, studies were grouped by modality, and were randomized and evaluated separately. Results: Our query yielded 76 patients (42 CRLMs; 34 NELMs) with low interrater variability (intraclass correlation coefficients: CT = 0.941, MRI = 0.975). For CRLMs, there were no significant differences in lesion number or size between CT and MRI. However, in NELMs, Eovist®-enhanced MRI detected more lesions (R1: 14.3 vs. 12.1, p = 0.02; R2: 14.4 vs. 12.4, p = 0.01) and smaller lesions (R1: 5.7 vs. 4.4, p = 0.03; R2: 4.8 vs. 2.9, p = 0.02) than CT. Conclusions: CT and MRI are equivalent for CRLMs, but for NELMs, MRI outperforms CT in detecting more and smaller lesions, potentially influencing treatment planning and surgery.
Cerebral Vasculopathy in Children with Neurofibromatosis Type 1
Authors: Lehman Laura L. , Ullrich Nicole J.
Published: October 2023

Cerebrovascular abnormalities are a severe and often underrecognized complication of childhood neurofibromatosis type 1 (NF1). There are no prospective studies of cerebral vasculopathy in NF1; thus, the estimated frequency of vasculopathy varies between studies. The data is difficult to interpret due to the retrospective data collection and variability in whether imaging is done based on screening/surveillance or due to acute neurologic symptoms. The prevalent NF1-associated cerebral vasculopathy is moyamoya syndrome (MMS). Vascular changes can present without symptoms or with acute TIA or stroke-like symptoms or a range of progressive neurologic deficits. Advanced imaging may enhance sensitivity of neuroimaging in children. Medical and/or surgical interventions may prevent short- and long-term complications. Challenges for establishment of a screening protocol for cerebral vasculopathy in children with NF1 include the relatively large number of patients with NF1, the potential need for sedation to achieve quality imaging and the broad age range at time of detection for cerebral vascular changes. The goal of this review is to present the epidemiology, clinical presentation, imaging features and medical/surgical management of cerebral arteriopathies in children with NF1.
Exploring Long Range para-Phenyl Effects in Unsymmetrically Fused bis(imino)pyridine-Cobalt Ethylene Polymerization Catalysts
Authors: Wang Yizhou , Wang Zheng , Zhang Qiuyue , Zou Song , Ma Yanping , Solan Gregory A. , Zhang Wenjuan , Sun Wen-Hua
Published: October 2023

Unsymmetrical 11-phenyl-1,2,3,7,8,9,10-heptahydrocyclohepta[b]quinoline-4,6-dione, incorporating a para-phenyl substituted pyridine unit fused by both 6- and 7-membered carbocyclic rings, has been prepared on the gram-scale via a multi-step procedure involving cyclization, hydrogenation and oxidation. Templating this diketone, in the presence of cobalt(II) chloride hexahydrate, with the corresponding aniline afforded in good yield five examples of doubly fused bis(arylimino)pyridine-cobalt(II) chlorides, Co1 (aryl = 2,6-dimethylphenyl), Co2 (2,6-diethylphenyl), Co3 (2,6-diisopropylphenyl), Co4 (2,4,6-trimethylphenyl) and Co5 (2,6-diethyl-4-methylphenyl). Structural characterization of Co1, Co2 and Co3 highlights the flexible nature of the inequivalent fused rings on the NNN’-ligand and the skewed disposition of the para-phenyl group. On activation with MAO, Co1–Co5 exhibited high activity for ethylene polymerization at 30 °C (up to 5.66 × 106 g (PE) mol−1 (Co) h−1) with the relative order being as follows: Co4 > Co1 > Co5 > Co3 > Co2. All polyethylenes were strictly linear, while their molecular weights and dispersities showed some notable variations. For Co1, Co2, Co4 and Co5, all polymerizations were well controlled as evidenced by the narrow dispersities of their polymers (Mw/Mn range: 1.8–2.7), while their molecular weights (Mw range: 2.9–10.9 kg mol−1) steadily increased in line with the greater steric properties of the N-aryl ortho-substituents. By contrast, the most hindered 2,6-diisopropyl counterpart Co3 displayed a broad distribution with bimodal characteristics (Mw/Mn = 10.3) and gave noticeably higher molecular weight polymer (Mw = 75.5 kg mol−1). By comparison, the MMAO-activated catalysts were generally less active, but showed similar trends in molecular weight and polymer dispersity. End group analysis of selected polymers via 13C and 1H NMR spectroscopy revealed the presence of both saturated and unsaturated polyethylenes in accordance with competing chain transfer pathways. Notably, when comparing Co3/MAO with its non-phenyl substituted analogue (E2,6-iPr2Ph)CoCl2/MAO, the former, though less controlled, displayed higher activity and molecular weight, a finding that points towards a role played by the remote para-phenyl group.
Transphyseal Humeral Separations: An Often-Missed Fracture
Authors: Hariharan Arun R. , Nugraha Hans K. , Ho Christine A. , Bauer Andrea , Mehlman Charles T. , Sponseller Paul D. , O’Hara Nathan N. , Abzug Joshua M.
Published: October 2023

Background: Transphyseal humeral separations (TPHS) are rare injuries often associated with non-accidental trauma, necessitating accurate diagnosis. This study aims to assess the accuracy of diagnosis of TPHS. Methods: A retrospective review was conducted at five academic pediatric institutions to identify all surgically treated TPHS in patients up to 4 years of age over a 25-year period. Demographics, misdiagnosis rates, and reported misdiagnoses were noted. Comparative analyses were performed to analyze the effects of patient age and injury mechanism on misdiagnosis rates. Results: Seventy-nine patients (average age: 17.4 months) were identified, with injury mechanisms including accidental trauma (n = 49), non-accidental trauma (n = 21), Cesarean-section (n = 6), and vaginal delivery (n = 3). Neither age nor injury mechanism were significantly associated with diagnostic accuracy in the emergency department (ED)/consulting physician group. ED/consulting physicians achieved an accurate diagnosis 46.7% of the time, while radiologists achieved an accurate diagnosis 26.7% of the time. Diagnostic accuracy did not correlate with Child Protective Services (CPS) involvement or with a delay in surgery of more than 24 h. However, a significant correlation (p = 0.03) was observed between injury mechanism and misdiagnosis rates. Conclusion: This multicenter analysis is the largest study assessing TPHS misdiagnosis rates, highlighting the need for raising awareness and considering advanced imaging or orthopedic consultation for accurate diagnosis. This also reminds orthopedic surgeons to always have vigilant assessment in treating pediatric elbow injuries. Level of Evidence: Level III–Retrospective Cohort Study.
Internalising and Externalising Symptoms and Their Association with the Family Environment in Young Children with Williams Syndrome: A Longitudinal Study
Authors: Ilic Tamara , Porter Melanie A. , Reeve Jessica L.
Published: October 2023

Williams Syndrome (WS) involves high rates of psychopathology across the lifespan. However, little is known about the early, longitudinal trajectory of internalising/externalising symptoms or the association between these and the family environment in WS. WS (n = 16; aged 2 years, 2 months to 9 years, 5 months) and typically developing or TD (n = 46; aged 2 years, 2 months to 11 years, 1 month) children were assessed on two occasions over 2.5 years utilising parent report questionnaires—the Child Behaviour Checklist and the Family Environment Scale. No statistically significant changes were found in CBCL/psychopathology profiles across timepoints, on average, for either WS or TD children. However, reliable change scores showed WS children had considerable variability in CBCL scores over time. Cross-sectionally, the WS group showed higher scores (reflecting more psychopathology) compared to TD controls at both time points across most CBCL subscales, with elevated overall psychopathology problems identified in 56–68% of WS children (versus 8% in TD controls). Psychopathology was not associated with sex, chronological age, or cognitive ability in WS. Conflict in the family environment was positively associated with higher Attention Problems at Time 1 in the WS group, whilst the TD group showed associations between family conflict and total psychopathology problems at both time points and between family cohesion and total psychopathology problems at Time 2. Family environment did not differ between groups, except for lower engagement in intellectual and cultural activities in WS. Findings highlight variable Internalising and Externalising Problems in young WS children over time, with greater biological than environmental contributions to psychopathology in WS.
Excitation Threshold Reduction Techniques for Organic Semiconductor Lasers: A Review
Authors: Wang Yao , Han Xu , Jin Linze , Meng Yuhui , Jiang Chengming , Asare-Yeboah Kyeiwaa , He Zhengran , Bi Sheng
Published: October 2023

Organic semiconductor lasers have shown great application potential in various fields, such as low-cost sensing, high-performance lighting and display, and lab-on-a-chip devices. Since the introduction of organic lasers in the 1960s, research on semiconductor laser devices has expanded to include various materials and structures. The organic laser has attracted much attention due to its wide range of emission spectrum and simple synthesis and processing. Researchers constantly pursue the goal of using organic semiconductors to fabricate low-threshold thin-film organic laser devices while retaining the characteristics of a wide luminescence spectrum of organic materials, simple and portable structure, and low cost. However, organic semiconductor lasers face challenges due to material stability under optical pumping and large optical losses under electrical pumping, making commercialization difficult. Many scholars have put great efforts into enhancing the performance of materials and optimizing the structure to minimize the threshold of organic semiconductor lasers. Herein, based on the basic principles of organic lasers, the main factors affecting the excitation threshold are summarized. A comprehensive analysis of the relevant factors and threshold conditions is performed, considering both positive and negative aspects of modal gain and modal loss that need to be addressed. We expect to provide a wide range of ideas for reducing the threshold of organic lasers and offer theoretical guidance for the practical industrial production of organic lasers.
Deepfake Attacks: Generation, Detection, Datasets, Challenges, and Research Directions
Authors: Naitali Amal , Ridouani Mohammed , Salahdine Fatima , Kaabouch Naima
Published: October 2023

Recent years have seen a substantial increase in interest in deepfakes, a fast-developing field at the nexus of artificial intelligence and multimedia. These artificial media creations, made possible by deep learning algorithms, allow for the manipulation and creation of digital content that is extremely realistic and challenging to identify from authentic content. Deepfakes can be used for entertainment, education, and research; however, they pose a range of significant problems across various domains, such as misinformation, political manipulation, propaganda, reputational damage, and fraud. This survey paper provides a general understanding of deepfakes and their creation; it also presents an overview of state-of-the-art detection techniques, existing datasets curated for deepfake research, as well as associated challenges and future research trends. By synthesizing existing knowledge and research, this survey aims to facilitate further advancements in deepfake detection and mitigation strategies, ultimately fostering a safer and more trustworthy digital environment.
Folliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides
Authors: Tang Haiming , Rybski Kristin J. , Luan Yi , Smoller Bruce R.
Published: October 2023

Programmed cell death protein 1 (PD-1) plays a pivotal role in immune system regulation, with its expression levels linked to malignancy prognosis. However, existing reports on PD-1 staining in mycosis fungoides (MF) present conflicting findings, and little attention has been given to PD-1 staining in different MF variants. To address this, we conducted a retrospective study, employing immunohistochemistry to examine PD-1 expression in cases of folliculotropic MF and non-folliculotropic MF. We analyzed 24 cases of folliculotropic MF and 18 cases of non-folliculotropic MF, and recorded both the percentage of PD-1-labeled tumor cells and the intensity score (negative, weak, medium, or strong). Our results revealed significant disparity in PD-1 labeling between patch/plaque MF and folliculotropic MF (p = 0.028). Non-folliculotropic MF exhibited higher PD-1 labeling in tumor cells (58.3%) compared to folliculotropic MF (40.2%). Notably, there was no significant difference in PD-1 staining between folliculotropic MF and non-folliculotropic MF when both were in the early stage/indolent disease category. However, when considering the tumor stage, folliculotropic MF exhibited PD-1 staining in tumor cells at a rate of 21.1%, while non-folliculotropic MF showed PD-1 staining in tumor cells at a rate of 46.6% (p = 0.005). Additionally, among folliculotropic MF cases, 13 out of 24 cases displayed differing PD-1 expression patterns between epidermal and dermal components, with preserved PD-1 staining in the epidermal component and loss of staining in the dermal component. Furthermore, consistent with the prior literature, tumor cells with large cell transformations exhibited significantly lower PD-1 labeling (p = 0.017). Our findings showcase the unique PD-1 staining patterns in MF.
Ask Doctor Smartphone! An App to Help Physicians Manage Foreign Body Ingestions in Children
Authors: Di Mitri Marco , Parente Giovanni , Bisanti Cristian , Thomas Eduje , Cravano Sara Maria , Cordola Chiara , Vastano Marzia , Collautti Edoardo , Di Carmine Annalisa , Maffi Michela , D’Antonio Simone , Libri Michele , Gargano Tommaso , Lima Mario
Published: October 2023

Background: Foreign body ingestion (FBI) represents the most common cause of emergent gastrointestinal endoscopy in children. FBI’s management can be quite challenging for physicians because of the variability of the clinical presentation, and the decision tree becomes even more intricate because of patient-specific variables that must be considered in the pediatric age range (e.g., age of patients and neuropsychiatric disorders) in addition to the mere characteristics of the foreign body. We present an application for smartphones designed for pediatricians and pediatric surgeons based on the latest guidelines from the official pediatric societies. The app aims to help physicians manage FBI quickly and properly in children. Materials and methods: The latest pediatric FBI management guidelines were reviewed and summarized. The flow chart we obtained guided the development of a smartphone application. A questionnaire was administered to all pediatric surgeon trainees at our institute to test the feasibility and helpfulness of the application. Results: An app for smartphones was obtained and shared for free on the Google Play Store and Apple Store. The app guides the physician step by step in the diagnostic process, analyzing all patient- and foreign body-specific characteristics. The app consultation ends with a suggestion of the most proper decision to make in terms of further radiological investigations and the indication and timing of endoscopy. A questionnaire administered to trainees proved the app to be useful and easy to use. Conclusion: We developed an app able to help pediatricians and pediatric surgeons manage FBI in children, providing standardized and updated recommendations in a smart and easily available way.
Role of SIRT1 Gene Polymorphisms and Serum Levels in Patients with Multiple Sclerosis
Authors: Kaikaryte Kriste , Gedvilaite Greta , Balnyte Renata , Uloziene Ingrida , Liutkeviciene Rasa
Published: October 2023

Aim: The purpose of this work was to investigate the prevalence of SIRT1 rs3818292, rs3758391, and rs7895833 single nucleotide polymorphisms and SIRT1 serum levels associated with multiple sclerosis (MS) in the Lithuanian population. Methods: A total of 250 MS patients and 250 healthy controls were included in the study. Genotyping was performed using the RT-PCR method. Statistical analysis was performed using “IBM SPSS version 29.0”. The serum SIRT1 level was determined by the ELISA method. Results: We found that rs3818292 was associated with increased odds of developing MS under the dominant (p = 0.007) and allelic genetic (p = 0.004) models. rs3758391 was associated with increased odds of developing under the co-dominant (p < 0.001), overdominant (p < 0.001), dominant (p < 0.001), and allelic (p = 0.002) genetic models. rs7895833 was associated with increased odds of developing MS under co-dominant (p < 0.001), overdominant (p < 0.001), dominant (p < 0.001), and allelic (p < 0.001) genetic models. Additional sex-differentiated analysis within females revealed that the rs3758391 was associated with an increased odds ratio for the occurrence of MS among the co-dominant (p = 0.006), dominant (p = 0.002), and allelic (p = 0.001). rs7895833 was associated with an increased odds ratio for the development of MS under the co-dominant (p < 0.001), overdominant (p < 0.001), dominant (p < 0.001), and allelic (p < 0.001) genetic models. Age-differentiated analysis showed that rs3758391 was associated with an increased odds ratio for the development of MS in younger patients under the codominant (p = 0.002), overdominant (p = 0.003), and dominant (p = 0.004) genetic models. rs7895833 was associated with an increased odds ratio for the occurrence of MS under the overdominant genetic model (p = 0.013). In elderly patients, rs3818292 was associated with an increased odds ratio for the occurrence of MS under the dominant (p = 0.008) and allelic (p = 0.009) genetic models. rs7895833 was associated with an increased odds ratio for the occurrence of MS under the codominant (p = 0.011 and p = 0.012), dominant (p = 0.001), and allelic (p < 0.001) genetic models. We also found that serum SIRT1 levels were statistically significantly different between MS patients and control group subjects (p < 0.001). In addition, comparison of SIRT1 levels between study groups and genotypes showed that rs3818292 AA (p = 0.001), rs3758391 CT (p < 0.001), and rs7895833 AA (p = 0.002) and AG (p = 0.004) had higher SIRT1 levels in the control group than in the MS group. All results were provided after strict Bonferroni correction. Conclusions: Genetic variations in SIRT1 rs3818292, rs3758391, and rs7895833 are associated with multiple sclerosis, with possible differences in gender and age, as well as lower serum SIRT1 levels.
Exploration and Enhancement of Classifiers in the Detection of Lung Cancer from Histopathological Images
Authors: Shanmugam Karthikeyan , Rajaguru Harikumar
Published: October 2023

Lung cancer is a prevalent malignancy that impacts individuals of all genders and is often diagnosed late due to delayed symptoms. To catch it early, researchers are developing algorithms to study lung cancer images. The primary objective of this work is to propose a novel approach for the detection of lung cancer using histopathological images. In this work, the histopathological images underwent preprocessing, followed by segmentation using a modified approach of KFCM-based segmentation and the segmented image intensity values were dimensionally reduced using Particle Swarm Optimization (PSO) and Grey Wolf Optimization (GWO). Algorithms such as KL Divergence and Invasive Weed Optimization (IWO) are used for feature selection. Seven different classifiers such as SVM, KNN, Random Forest, Decision Tree, Softmax Discriminant, Multilayer Perceptron, and BLDC were used to analyze and classify the images as benign or malignant. Results were compared using standard metrics, and kappa analysis assessed classifier agreement. The Decision Tree Classifier with GWO feature extraction achieved good accuracy of 85.01% without feature selection and hyperparameter tuning approaches. Furthermore, we present a methodology to enhance the accuracy of the classifiers by employing hyperparameter tuning algorithms based on Adam and RAdam. By combining features from GWO and IWO, and using the RAdam algorithm, the Decision Tree classifier achieves the commendable accuracy of 91.57%.
Advanced Exergy-Based Analysis of an Organic Rankine Cycle (ORC) for Waste Heat Recovery
Authors: Fergani Zineb , Morosuk Tatiana
Published: October 2023

In this study, advanced exergy and exergoeconomic analysis are applied to an Organic Rankine Cycle (ORC) for waste heat recovery to identify the potential for thermodynamic and economic improvement of the system (splitting the decision variables into avoidable/unavoidable parts) and the interdependencies between the components (endogenous and exogenous parts). For the first time, the advanced analysis has been applied under different conditions: constant heat rate supplied to the ORC or constant power generated by the ORC. The system simulation was performed in Matlab. The results show that the interactions among components of the ORC system are not strong; therefore, the approach of component-by-component optimization can be applied. The evaporator and condenser are important components to be improved from both thermodynamic and cost perspectives. The advanced exergoeconomic (graphical) optimization of these components indicates that the minimum temperature difference in the evaporator should be increased while the minimum temperature difference in the condenser should be decreased. The optimization results show that the exergetic efficiency of the ORC system can be improved from 27.1% to 27.7%, while the cost of generated electricity decreased from 18.14 USD/GJ to 18.09 USD/GJ.
Productivity and Global Value Chains: A Tale from the Indonesian Automobile Sector
Authors: Wicaksono Padang , Hikmah Yulial , Ilmiawani Rayinda Nur
Published: October 2023

Low productivity and quality of employment have always been a big problem in Indonesia, caused by the lack and mismatch of skills in the workforce. Labor productivity (LP) describes the company’s ability to produce something. This can be determined by added value or output. Several factors influence LP, such as education, age, and training. The concept of global value chains (GVCs) has become an integral part of economic activity, and trade within global production networks has grown more rapidly than conventional trade in final goods. GVCs have both positive and negative impacts on employment opportunities. The automotive industry is categorised as one of the ten primary priority industries in the Indonesian manufacturing sector. This research analyses the impact of LP on GVC integration in the Indonesian automotive industry. The data used in this research comes from the World Input–Output Database (WIOD) and the Central Statistics Agency (BPS) from 1995 to 2014. The variables used include the number of workers, added value, real wages, and GVC, which were calculated by the author using the Inter-Country Input–Output (ICIO) approach. Using ICIO analysis, the following matrix should be constructed to determine involvement in GVCs. This research shows that LP in the Indonesian automotive industry has a positive trend, and the GVC position in the Indonesian automotive industry has a positive trend line. The domestic value chain increased from 4% to 33%. This improves the ability to produce higher value-added and intermediate export goods. LP increases the domestic value chain in the Indonesian automotive industry, leading to global value chain integration. Thus, LP goes hand in hand with integrating GVCs.
Mixed-Reality Simulation to Support Practice Learning of Preservice Teachers
Authors: Gravett Sarah , Van der Merwe Dean , Ramsaroop Sarita , Tshabalala Pamela , Bremner Casey , Mello Pumzile
Published: October 2023

Before the COVID-19 pandemic, providing high-quality practice learning experiences for preservice teachers was already taxing due to the heavy reliance on school practicum, which is often besieged with challenges. Given these challenges, there is a growing urgency to explore alternative avenues for offering practice learning experiences to preservice teachers in addition to school practicum. With this backdrop, a qualitative study was conducted, employing observation and interviews as data collection methods to explore the potential of mixed-reality simulation (MRS) to strengthen the practice learning experiences of preservice teachers. The core teaching practice of questioning was chosen to explore the affordances of MRS for improving preservice teachers’ understanding of and proficiency in utilizing questioning. This study found that MRS provides a low-risk learning environment that preservice teachers perceive as authentic. For these reasons, this environment is conducive to improvement, and it enables deliberate practice, which is vital for nurturing metacognition and adaptive expertise. The findings also highlight the importance of coaching for maximizing MRS advantages. The absence of coaching will most likely limit the affordances of MRS as an approximation of teaching practice. While our findings are promising, the resource-intensive nature of MRS implementation means that scalability requires further investigation.
Learning Analytics: A View on the Design and Assessment of Asynchronous Online Discussions for Better Teaching Performance
Authors: Fernández-Olaskoaga Lorea , Guitert Catasús Montse , Romeu Fontanillas Teresa , Cerro Martínez Juan Pedro
Published: October 2023

In recent years, the impact of learning analytics has been investigated and explored in higher education contexts. This article aims to show how their application in online educational contexts is providing great support for teaching performance, especially in relation to the methodology applied, the monitoring of students’ interactions and participation, and the evaluation of activities, and how it can favor improvements in student performance and satisfaction. We therefore present the results obtained from use of the DIANA (DIAlog ANAlysis) tool designed for the research project “Use of learning analytics in digital environments: impact on the improvement of university teaching practice” (LAxDigTeach-21085GE). This study followed a mixed methodology (qualitative and quantitative) to better complement the data provided by learning analytics, given that the numerical data must be meaningful in the specific context in which they are collected. The results obtained are in line with previous research and show that the use of learning analytics have helped to improve teaching performance in relation to monitoring student interactions, participation, and evaluation, but are limited in terms of improving their performance and satisfaction. No generalized conclusions can be drawn as yet in light of the fact that the research project of which this study is a part has recently completed the pilot stage and we have only analyzed the information obtained in one of the participating subjects.
Smart Switching in Single-Phase Grid-Connected Photovoltaic Power Systems for Inrush Current Elimination
Authors: Martínez-Figueroa Gerardo de J. , Bogarra Santiago , Córcoles Felipe
Published: October 2023

Grid-connected photovoltaic (PV) power systems are one of the most promising technologies to address growing energy demand and ecological challenges. This paper proposes smart switching to mitigate inrush currents during the connection of single-phase transformers used in PV systems. An effective inrush current mitigation contributes to the reliability of PV systems. The inrush current severity is influenced by the pseudorandom residual flux at the transformer core and the energization point-on-wave. The most common approach to avoid inrush currents is controlled connection, which requires prior knowledge of the residual flux. However, the residual flux can differ in each case, and its measurement or estimation can be impractical. The proposed smart switching is based on a comprehensive analysis of the residual flux and the de-energization trajectories, and only requires two pieces of data (ϕRM and ϕ0, flux values of the static and dynamic loops when the respective currents are null), calculated from two simple no-load tests. It has a clear advantage over common approaches: no need to estimate or measure the residual flux before each connection, avoiding the need for expensive equipment or complex setups. Smart switching can be easily implemented in practical settings, as it considers different circuit breakers with distinctive aperture features, making it cost-effective for PV systems.
The Effects of Multistage Fuel-Oxidation Chemistry, Soot Radiation, and Real Gas Properties on the Operation Process of Compression Ignition Engines
Authors: Basevich Valentin Y. , Frolov Sergey M. , Ivanov Vladislav S. , Frolov Fedor S. , Semenov Ilya V.
Published: October 2023

The objectives of the study are to reveal the influence of multistage fuel-oxidation chemistry, thermal radiation of soot during the combustion of a small (submillimeter size) fuel droplet, and real gas effects on the operation process of compression ignition engines. The use of the multistage oxidation chemistry of iso-octane in the zero-dimensional approximation reveals the appearance of different combinations of cool, blue, and hot flames at different compression ratios and provides a kinetic interpretation of these phenomena that affect the heat release function. Cool flames are caused by the decomposition of alkyl hydroperoxide, during which a very reactive radical, OH, is formed. Blue flames are caused by the decomposition of H2O2 with the formation of OH. Hot flames are caused by the chain branching reaction between atomic hydrogen and molecular oxygen with the formation of OH and O. So-called “double” cool flames correspond to the sequential appearance of a separated cool flame and a low-intensity blue flame rather than two successive cool flames. The use of a one-dimensional model of fuel droplet heating, evaporation, autoignition, and combustion at temperatures and pressures relevant to compression ignition engines shows that the thermal radiation of soot during the combustion of small (submillimeter size) droplets is insignificant and can be neglected. The use of real gas caloric and thermal equations of state of the matter in a three-dimensional simulation of the operation process in a diesel engine demonstrates the significant effect of real gas properties on the engine pressure diagram and on the NO and soot emissions: real gas effects reduce the maximum pressure and mass-averaged temperature in the combustion chamber by about 6 and 9%, respectively, increases the autoignition delay time by a 1.6 crank angle degree, increase the maximum heat release rate by 20%, and reduce the yields of NO and soot by a factor of 2 and 4, respectively.
Social Monetary Valuation for Protecting Forests and Protected Wild Animals in North Sulawesi, Indonesia
Authors: Mauri Jerry , Huang Yingli , Harbi Jun
Published: October 2023

Many protected wild animal species are threatened with extinction because of degraded forest habitats. We conducted a monetary assessment of social responses to this issue in North Sulawesi, Indonesia. Respondents were asked to determine a monetary value for forest services, and we measured willingness to pay (WTP) using the collection of compensation funds every year for five years. A descriptive statistical model, a correlation analysis, and a double-bounded dichotomous choice (DBDC) model were used in this study. There were 92.1% of respondents who claimed to be aware of the environment, as well as 96% of protected animals, and 89.8% who agreed with the compensation fund. There is a need for current socialization of the environmental situation, and it is necessary to consider education and income factors for real actions in the future. The estimated monetary value probability for WTP was determined using accepting the median estimate of IDR 264,820 (USD 18.26). These results estimated the value of annual forest protection over five years.