bluuebunny/crossref_metadata_2025 huggingface dataset:
Poliovirus Immunity among Children Aged 6–11 and 36–48 Months in 14 Polio High-Risk Provinces of Afghanistan: A Health-Facility-Based Study
Authors: Soofi Sajid Bashir , Martinez Maureen , Farag Noha H. , Hendley William S. , Ehrhardt Derek , Ahmed Imran , Hussain Imtiaz , Weldon William , Kassem Ahmed M.
Published: October 2022

Afghanistan is one of two countries where wild poliovirus (WPV) type 1 remains endemic. We conducted a facility-based cross-sectional survey of antipoliovirus antibodies in children in 14 provinces of Afghanistan. The provinces were selected based on programmatic priorities for polio eradication. Children aged 6–11 and 36–48 months attending outpatient clinics were enrolled in the study. We collected venous blood, isolated serum, and conducted neutralization assays to detect poliovirus neutralizing antibodies. A total of 2086 children from the 14 provinces were enrolled. Among the enrolled children, 44.3% were girls; the median age in the 6–11-month group was 9.4 months, and in the 36–48-month group, it was 41.8 months. The most common spoken language was Pashtu (70.8%). Eighty-two percent of children were fully immunized against all the diseases in the vaccination schedule of Afghanistan. In the children aged 6–11 months, seroprevalence to poliovirus type 1 (PV1) was 96.5% and seroprevalence to poliovirus type 3 (PV3) was 93%; in children aged 36–48 months, seroprevalence to PV1 was 99.5% and to PV3 was 98%. Antipoliovirus antibody prevalence for poliovirus type 2 (PV2) was 70.5% in the younger group compared with 90.9% in the older children. Children from Herat and Laghman provinces had almost 100% seroprevalence to PV1, and other provinces also had high prevalence, ranging from 92.0% to 99.0%. A similar finding was seen for antibodies against PV3, ranging from 88% to 100% by province. On the contrary, antibodies to PV2 were low, ranging from 53% for children in the Khost province to around 89% in Kunduz. There was a cluster of 18 seronegative children in the Nuristan province. Overall, the polio eradication program of Afghanistan has been successful in achieving high seroprevalence of poliovirus neutralizing antibodies in the parts of the country included in this study.
Genome-Based Multi-Antigenic Epitopes Vaccine Construct Designing against Staphylococcus hominis Using Reverse Vaccinology and Biophysical Approaches
Authors: Nawaz Mahreen , Ullah Asad , Al-Harbi Alhanouf I. , Haq Mahboob Ul , Hameed Alaa R. , Ahmad Sajjad , Aziz Aamir , Raziq Khadija , Khan Saifullah , Irfan Muhammad , Muhammad Riaz
Published: October 2022

Staphylococcus hominis is a Gram-positive bacterium from the staphylococcus genus; it is also a member of coagulase-negative staphylococci because of its opportunistic nature and ability to cause life-threatening bloodstream infections in immunocompromised patients. Gram-positive and opportunistic bacteria have become a major concern for the medical community. It has also drawn the attention of scientists due to the evaluation of immune evasion tactics and the development of multidrug-resistant strains. This prompted the need to explore novel therapeutic approaches as an alternative to antibiotics. The current study aimed to develop a broad-spectrum, multi-epitope vaccine to control bacterial infections and reduce the burden on healthcare systems. A computational framework was designed to filter the immunogenic potent vaccine candidate. This framework consists of pan-genomics, subtractive proteomics, and immunoinformatics approaches to prioritize vaccine candidates. A total of 12,285 core proteins were obtained using a pan-genome analysis of all strains. The screening of the core proteins resulted in the selection of only two proteins for the next epitope prediction phase. Eleven B-cell derived T-cell epitopes were selected that met the criteria of different immunoinformatics approaches such as allergenicity, antigenicity, immunogenicity, and toxicity. A vaccine construct was formulated using EAAAK and GPGPG linkers and a cholera toxin B subunit. This formulated vaccine construct was further used for downward analysis. The vaccine was loop refined and improved for structure stability through disulfide engineering. For an efficient expression, the codons were optimized as per the usage pattern of the E coli (K12) expression system. The top three refined docked complexes of the vaccine that docked with the MHC-I, MHC-II, and TLR-4 receptors were selected, which proved the best binding potential of the vaccine with immune receptors; this was followed by molecular dynamic simulations. The results indicate the best intermolecular bonding between immune receptors and vaccine epitopes and that they are exposed to the host’s immune system. Finally, the binding energies were calculated to confirm the binding stability of the docked complexes. This work aimed to provide a manageable list of immunogenic and antigenic epitopes that could be used as potent vaccine candidates for experimental in vivo and in vitro studies.
Fresh Air for the Mire-Breathing Hypothesis: Sphagnum Moss and Peat Structure Regulate the Response of CO2 Exchange to Altered Hydrology in a Northern Peatland Ecosystem
Authors: O’Neill Ally , Tucker Colin , Kane Evan S.
Published: October 2022

Sphagnum-dominated peatlands store more carbon than all of Earth’s forests, playing a large role in the balance of carbon dioxide. However, these carbon sinks face an uncertain future as the changing climate is likely to cause water stress, potentially reducing Sphagnum productivity and transitioning peatlands to carbon sources. A mesocosm experiment was performed on thirty-two peat cores collected from two peatland landforms: elevated mounds (hummocks) and lower, flat areas of the peatland (hollows). Both rainfall treatments and water tables were manipulated, and CO2 fluxes were measured. Other studies have observed peat subsiding and tracking the water table downward when experiencing water stress, thought to be a self-preservation technique termed ‘Mire-breathing’. However, we found that hummocks tended to compress inwards, rather than subsiding towards the lowered water table as significantly as hollows. Lower peat height was linearly associated with reduced gross primary production (GPP) in response to lowered water tables, indicating that peat subsidence did not significantly enhance the resistance of GPP to drought. Conversely, Sphagnum peat compression was found to stabilize GPP, indicating that this mechanism of resilience to drought may transmit across the landscape depending on which Sphagnum landform types are dominant. This study draws direct connections between Sphagnum traits and peatland hydrology and carbon cycling.
Geochemistry of Groundwater in the Semi-Arid Crystalline Terrain of Sri Lanka and Its Health Implications among Agricultural Communities
Authors: Udeshani W. A. Charitha , Koralegedara Nadeesha H. , Gunatilake S. K. , Li Si-Liang , Zhu Xiangyu , Chandrajith Rohana
Published: October 2022

Chronic kidney disease with uncertain etiology (CKDu) is an emerging health problem in Sri Lanka, particularly among the dry-zone farming communities that use groundwater for drinking. We investigated the quality of groundwater in an area where both high- and low-prevalence clusters of CKDu have been recorded. Eighty-four groundwater and five surface water samples, covering the selected region, were collected and analyzed for both major anions and cations. The groundwater in the region is mainly of the Ca-Mg-HCO3 type, probably due to the long residence time in fractured hard rock aquifers in this region. Irrespective of the CKDu prevalence, over 50% of samples exceeded the recommended limits for EC/TDS, alkalinity, hardness, and Mg2+ content in groundwater. Water hardness in CKDu clusters was dominated by Mg2+. High fluoride content up to 4.0 mg/L was also found in most groundwater samples from the region. The water quality index (WQI) values indicated that 42% of the groundwater samples in regions with no or low CKDu prevalence and 49% of the samples in regions with high prevalence were poor in quality. The spatial distribution of WQI and fluoride concentration overlapped, indicating the direct influence of fluoride on the groundwater quality in the study region. In addition, regions with higher WQI values overlapped with the CKDu hotspots, indicating the direct impact of groundwater quality on the disease prevalence in the studied river basin. The WQI can be used to effectively demarcate areas with possible groundwater-related health effects in the dry-zone regions of Sri Lanka.
Microplastic Distribution through the Salinity Gradient in a Stratified Estuary
Authors: Parać Marija , Cuculić Vlado , Cukrov Nuša , Geček Sunčana , Lovrić Marin , Cukrov Neven
Published: October 2022

Despite the extensive and rapidly growing literature on microplastics in oceans and coastal seas, little information exists on microplastic distribution through the salinity gradient. This study is the first one to evaluate microplastic distribution through the salinity gradient of a highly stratified estuary. A total of 910 microplastic particles were collected from 12 different sampling events in the Krka River estuary, Croatia. The number of detected particles ranged from 389 in the surface layer to 63 in the deepest marine layer. The highest plastic abundance was found in the surface layer (3.68 particles/m3) and the lowest in the marine layer (0.13 particles/m3). The measured values of the cross-sectional area indicated an ellipsoidal cross-sectional shape of the particles. It was also found that the majority of microplastic particles belonged to the small microplastic class (<1 mm). The Nile Red (NR) staining method was used to visualize fluorescent microplastic particles, while quantification was performed using ImageJ/Fiji software. The strong salinity stratification in the studied estuary did not alter the usual distribution of microplastic particles in the water column, and there was no significant accumulation on the halocline.
Energy Analysis of a Quasi-Two-Dimensional Friction Model for Simulation of Transient Flows in Viscoelastic Pipes
Authors: Wu Kai , Feng Yujie , Xu Ying , Liang Huan , Liu Guohong
Published: October 2022

Quasi-two-dimensional (quasi-2D) friction models have been widely investigated in transient pipe flows. In the case of viscoelastic pipes, however, the effect of different values of the Reynolds number (Re) on pressure fluctuations (which can lead to water hammer) have not been considered in detail. This study establishes a quasi-2D friction model employing an integral total energy method and investigates the work due to frictional and viscoelastic terms at different Re values. The results show that viscoelastic work (WP) and frictional work (Df) increase with an increase in Re. However, when the initial Re values are high, the Df values are much larger than the WP values. In addition, for Re < 3 × 105, the 1D model underestimated the viscoelastic terms. There was no significant difference between the two models for Re > 3 × 105. In the case of different initial Re values, the two models produced almost the same values for WP. This study provides a theoretical basis for investigating transient flow from the perspective of energy analysis.
Economic Evaluation of Drought Resistance Measures for Maize Seed Production Based on TOPSIS Model and Combination Weighting Optimization
Authors: Liang Chao , Yu Shouchao , Zhang Hengjia , Wang Zeyi , Li Fuqiang
Published: October 2022

In order to optimize the appropriate drought resistance measures in the implementation of high-efficiency and intensive production of maize seed, in 2018 and 2019, maize cultivation experiments with different drought resistance measures were carried out in the arid area of northwest China, including water retention agent (SA), white plastic film mulch (WF), black plastic film mulch (BF), straw mulch (SM), and open ground flat seed as control (CK). A total of five treatments were conducted. Ten specific indicators contained four types of attributes, namely the yield, quality, water use efficiency (WUE), and economic benefit of maize seed production, aimed at constructing a multilevel evaluation system. To improve the reliability of evaluation results, subjective and objective weights of indexes were calculated using the analytic hierarchy process (AHP) and entropy weight method (EWM), respectively. Then, based on the integrated weighting method of game theory (GT), the combined weights of subjective and objective unity were obtained. Finally, with the help of the technique for order preference by similarity to ideal solution (TOPSIS), a comprehensive benefit evaluation model was established to screen out the optimal drought resistance measures. Compared with CK, different drought resistance measures significantly improved the grain quality of seeds-production corn, and the average annual yield and WUE of black and white film treatments were improved by 49.57% and 42.97% and by 65.67% and 58.21%, respectively. This proved that black film mulching (BF) could significantly increase the yield and WUE of maize seed production and effectively improve grain quality, which could be used as the best drought-resistant cultivation mode for maize seed planting in Hexi and similar areas.
The “Semiconductor Crisis” as a Result of the COVID-19 Pandemic and Impacts on the Automotive Industry and Its Supply Chains
Authors: Frieske Benjamin , Stieler Sylvia
Published: October 2022

In the first half of 2020, the coronavirus pandemic led to a drastic slump in the automotive industry, which was replaced by a surprisingly rapid growth in demand in the fall of 2020, and consequently led to the current shortages in microelectronic products. The prospect of an equally rapid economic recovery in the automotive industry is still threatened by supply bottlenecks for raw materials and key components, foremost for semiconductors. The so-called ‘semiconductor crises’ show exemplarily the overlapping of short-term supply chain disruptions with long-term structural features of the semiconductor industry. The combination of both is preventing that the supply situation in the automotive industry will improve quickly. First in this paper, the reasons for and respective effects of the crisis on the automotive industry are investigated by a quantitative market analysis. Second, specific strategic measures and options of automotive Original Equipment Manufacturers (OEM) and suppliers in Germany to cope with the situation and increase resilience in future supply chains are described by the means of qualitative expert interviews. By that, the paper helps in understanding the actual situation in the automotive industry, on the one hand, and contributes to the field of strategic supply chain and risk management with a focus on practical implications on the other hand. The results aim to support political stakeholders as well as small and medium sized enterprises to prepare themselves for future developments in the automotive market and changes in manufacturer–supplier relationships due to the transformation to new powertrain technologies and digitization.
Potential Explanatory Models of the Female Preponderance in Very Late Onset Schizophrenia
Authors: Johnstone Samantha , Dela Cruz Gil Angela , Girard Todd A. , Rajji Tarek K. , Castle David J.
Published: October 2022

Epidemiological and clinical studies have uniformly reported an overrepresentation of females with very-late-onset schizophrenia-like psychotic disorder (VLOS), in stark contrast to the sex distribution of early-onset schizophrenia. Various explanatory models have been proposed to account for these sex differences, including (a) antidopaminergic effects of estrogen, (b) differential vulnerability to subtypes, (c) neurodegenerative differences between the sexes, and (d) and sex differences in age-related psychosocial and neurological risk factors; however, these models have not yet been critically evaluated for their validity. Keywords related to VLOS symptomatology, epidemiology, and sex/gender were entered into the PubMed, MEDLINE, and Google Scholar databases spanning all years. Through a narrative review of symptomatology and pathophysiology of VLOS, we examine the strengths and limitations of the proposed models. We present a comprehensive biopsychosocial perspective to integrate the above models with a focus on the role of neuroinflammation. There is significant room for further research into the mechanisms of VLOS that may help to explain the female preponderance; the effects of estrogen and menopause, neuroinflammation, and dopaminergic transmission; and their interaction with age-related and lifetime psychosocial stressors and underlying biological vulnerabilities.
Alveolar cleft bone grafting at different age periods
Authors: Yakovlev S. V. , Topolnitsky O. Z. , Pershina M. A. , Shonicheva Yu. A. , Gurgenadze A. P. , Makeev A. V. , Beglaryan A. A. , Bakshi T. A.
Published: October 2022

Relevance. Anatomical and functional disorders in congenital clefts may be various. Their severity depends on the cleft size and on the combination of a cleft lip with an alveolar cleft. Alveolar cleft bone grafting (ACBG) is one of the most important surgeries for patients with cleft lip and palate rehabilitation. The study aimed to analyze the results of alveolar cleft bone grafting in various age groups, summarizing the available data and supplementing them with our own experience.

Materials and methods. In our clinic, 488 patients of different ages (from 4 to 18 years old), including patients with bilateral clefts, underwent ACBG.

Results. The result analysis showed the time of surgery should depend not on the child's age but on the orthodontic preparation of the child for ACBG.

Conclusion. The literature data and our experience allowed us to develop indications for ACBG at different ages
Environmental Exposures and Kidney Disease
Authors: Kshirsagar Abhijit V. , Zeitler Evan M. , Weaver Anne , Franceschini Nora , Engel Lawrence S.
Published: October 2022

Accumulating evidence underscores the large role played by the environment in the health of communities and individuals. We review the currently known contribution of environmental exposures and pollutants on kidney disease and its associated morbidity. We review air pollutants, such as particulate matter; water pollutants, such as trace elements, per- and polyfluoroalkyl substances, and pesticides; and extreme weather events and natural disasters. We also discuss gaps in the evidence that presently relies heavily on observational studies and animal models, and propose using recently developed analytic methods to help bridge the gaps. With the expected increase in the intensity and frequency of many environmental exposures in the decades to come, an improved understanding of their potential effect on kidney disease is crucial to mitigate potential morbidity and mortality.
Sıyâmî ve Yeni Bir Eseri: Hakâyık u Dekâyık
Authors: ŞAHİN ÖZTAŞ Esma
Published: October 2022

16. yüzyıl şairlerinden Sıyâmî, yakın zamanlara kadar herhangi bir eseri bilinmediği için adından söz edilmeyen, biyografik kaynakların satır aralarında saklı kalmış bir şairdi. Sıyâmî ismi, ilk olarak tespit edilen Dîvân’ı ve Dîvân içindeki Antakya Şehrengizi ile yakın zamanlarda anılmaya başlanmış, daha sonra Hümâ vü Hümâyûn adlı bir mesnevisi bulunduğu ortaya çıkmıştır. Hakâyık u Dekâyık şairin tespit edilmiş yeni bir eseridir. Bu eserle birlikte şu ana kadar şaire ait gün yüzüne çıkan eser sayısı dörde ulaşmıştır. Tezkire yazarı Ahdî’nin özensiz de olsa çok yazan bir şair olarak zikretmesine bakılırsa Sıyâmî’nin kütüphanelerde keşfedilmeyi bekleyen başka eserleri bulunması muhtemeldir.
Sıyâmî’nin makalenin konusu olan Hakâyık u Dekâyık eseri tasavvufi-alegorik bir mesnevidir. Avusturya Ulusal Kütüphanesi’nde bir nüshası bulunan eser bu makale ile tanıtılmıştır. Makalede önce tezkirelerde adı geçen Sıyâmîler arasından tanıtımı yapılacak eserin sahibi Sıyâmî ve hakkındaki bilgiler netleştirilmeye çalışılmıştır. Daha sonra bazı mecmualardan şairin kimliği ve kişiliği hakkında ipucu taşıyan bilgiler derlenerek değerlendirilmiştir. Şairin hâlihazırda bilinen eserleri genel hatlarıyla tanıtıldıktan sonra yeni tespit edilen eserinin nüsha tavsifi yapılmış ve konusu hakkında bilgi verilmiştir. Eser, diğer eserlerine kıyasla şairin tasavvufî kimliğini birebir yansıtması yanında memleketini bizzat kendi dilinden nakletmesiyle Ahdî’nin verdiği bilgiyi doğrulayıp pekiştirerek biyografisine sunduğu katkı bakımından önemlidir.
РОЗВИТОК ОРГАНІЗАЦІЙНОЇ КОМПЕТЕНТНОСТІ МІСЬКОГО ГОЛОВИ ЯК ПОСАДОВОЇ ОСОБИ МІСЦЕВОГО САМОВРЯДУВАННЯ В КОНТЕКСТІ УКРАЇНСЬКО-НІМЕЦЬКОГО ПРОЄКТУ
Authors: Dzeha Volodymyr
Published: October 2022

У статті розкрито досвід європейських країн щодо розвитку організаційної компетентності посадових осіб місцевого самоврядування, які сприяють реалізації державної політики, економіки та соціальної сфери у глобалізаційних умовах.
Автор з'ясовує передумови для розвитку організаційної компетентності посадових осіб місцевого самоврядування в Україні, що складає їх професійну (управлінську) компетентність, передбачену Національною рамкою кваліфікацій, чинними законами України «Про вищу освіту», «Про інноваційну діяльність», загальними вимогами ЄС до керівних питань роботи органів громадської влади. Адже децентралізація стала тим стимулом, який передбачає зростання місцевої рішучості економічного вибору, фокусування на визначенні та використанні конкурентних переваг та ухвалення місцевих рішень щодо місцевої податкової політики, розвитку робочих місць та якості життя. Закордонний досвід демонструє, що володіння посадовими особами місцевого самоврядування організаційними компетентностями сприяє швидкому переходу до управління шляхом розробки стратегій, формування довгострокових цілей економічного зростання на місцевому рівні з паралельним вирішенням поточних проблем місцевого розвитку; застосування системного підходу до визначення проблем, формування завдань, які мають бути вирішені на місці; залучення та оптимальне використання ресурсів (насамперед місцевих); зростання відповідальності місцевої влади за розвиток та її самостійності; запровадження публічності у прийнятті рішень щодо задіяння механізмів, інструментів. Це стимулювання дозволяє більш обґрунтовано підходити до визначення напрямів місцевого розвитку територіальних громад.
Застосування сучасних інструментів місцевого соціально-економічного розвитку обумовлюється вмінням посадових осіб місцевого самоврядування застосовувати організаційні компетентності у лідерстві та командній роботі над стратегічними завданнями, визначеними пріоритетними для їх розвитку, залучення інвестицій; розвитком людських ресурсів, формуванням грошових потоків громади.
Перевірено рівень готовності посадових осіб місцевого самоврядування до провадження організаційної діяльності не лише у стабільних умовах, а також в умовах воєнного стану в Україні та в контексті трансформаційних змін, які відбуваються у зв'язку з набуттям Україною статусу кандидата-члена Європейського Союзу.
Precise Design and Deliberate Tuning of Turn-On Fluorescence in Tetraphenylpyrazine-Based Metal−Organic Frameworks
Authors: Zheng He-Qi , Zhang Lin , Lu Mengting , Xiao Xiaoyan , Yang Yu , Cui Yuanjing , Qian Guodong
Published: October 2022

The manipulation on turn-on fluorescence in solid state materials attracts increasing interests owing to their widespread applications. Herein we report how the nonradiative pathways of tetraphenylpyrazine (TPP) units in metal−organic frameworks (MOFs) systems could be hindered through a topological design approach. Two MOFs single crystals of different topology were constructed via the solvothermal reaction of a TPP-based 4,4

′

,4

″

,4

‴

-(pyrazine-2,3,5,6-tetrayl) tetrabenzoic acid (H
4
TCPP) ligand and metal cations, and their mechanisms of formation have been explored. Compared with the innate low-frequency vibrational modes of flu net Tb-TCPP-1, such as phenyl ring torsions and pyrazine twists, Tb-TCPP-2 adopts a shp net, so the dihedral angle of pyrazine ring and phenyl arms is larger, and the center pyrazine ring in TPP unit is coplanar, which hinders the radiationless decay of TPP moieties in Tb-TCPP-2. Thereby Tb-TCPP-2 exhibits a larger blue-shifted fluorescence and a higher fluorescence quantum yield than Tb-TCPP-1, which is consistent with the reduced nonradiative pathways. Furthermore, Density functional theory (DFT) studies also confirmed aforementioned tunable turn-on fluorescence mechanism. Our work constructed TPP-type MOFs based on a deliberately topological design approach, and the precise design of turn-on fluorescence holds promise as a strategy for controlling nonradiative pathways.
Innovation and Key Benefits of Business Models in Blockchain Companies
Authors: Aini Qurotul , Manongga Danny , Rahardja Untung , Sembiring Irwan , Efendy Rifan
Published: October 2022

Existing business models are changed and disrupted by blockchain technology, which warrants more research. This study tries to describe the phenomena of blockchain technology in relation to business model innovation in the enterprise ecosystem on the basis of that. Blockchain technology has been shown to increase organizational performance empirically. The value system concept is used in this study to explain this phenomena. This study employs a multiple-case study to respond to research questions using abductive reasoning. Overall, the outcomes According to this study, blockchain technology benefits an organization in four different ways: I value capture through higher profitability; (ii) value creation through private partnerships; (iii) value delivery through smart contracts; and (iv) value proposition that drives value by raising the organization's business value through operational improvements. This report also suggests a blockchain ecosystem with various private and consortium organizations. Private ecosystem focused on internal organizational performance enhancement within one corporate enterprise. The consortium ecosystem, on the other hand, is focused on fostering corporate cooperation.
Agresivitas Pajak Ditinjau dari Resiko Perusahaan, Likuiditas dan KAP Big Four
Authors: Firmansyah Firmansyah , Layli Meutia , Utomo Cyntha Mellia Febrina
Published: October 2022

This study aims to find empirical evidence by analyzing the effect of corporate risk, liquidity, and Big Four Firm of Public Accountants variables on tax aggressiveness in basic and chemical manufacturing companies listed on the IDX for the 2016–2020 period. In this study, there were 24 manufacturing companies in the basic and chemical industry sectors listed on the IDX for the 2016 – 2020 period. The sampling technique was purposive sampling. The data was obtained from the official website of the Indonesia Stock Exchange. Testing the research hypothesis using multiple linear regression models. The purpose of this study is to understand the existence of any factors that affect tax aggressiveness. The results of this study indicate that the company's risk has a positive effect on tax aggressiveness. This shows that the higher the risk of the company, the higher the tax aggressiveness in the company, while the liquidity and Big Four Firm of Public Accountants variables do not affect tax aggressiveness. The company's risk of tax aggressiveness can reduce the value of trust in the community. The existence of external control, namely Big Four Firm of Public Accountants does not experience a significant difference.
Nulidad e ilegalidad del acto administrativo frente a la restitución de remuneraciones dejadas de percibir
Authors: Ruiz-Bautista José Antonio , Vaca-Acosta Pablo Miguel , Castro-Sánchez Fernando-De-Jesús , Benalcázar-Guerrón Juan Carlos
Published: October 2022

Se tiene por objetivo analizar la nulidad e ilegalidad del acto administrativo frente a la restitución de remuneraciones dejadas de percibir. Al tipo de investigación es documental descriptivo con diseño bibliográfico. Cabe concluir que únicamente no procede el pago de las remuneraciones dejadas de percibir cuando el administrado durante el tiempo que estuvo destituido haya laborado como servidor público en otra cartera de Estado percibiendo su remuneración. En este caso en particular dichos rubros serán deducibles del monto ordenado pagar en la sentencia dictada por el Tribunal Contencioso Administrativo o por la sala especializada de la Corte Nacional de Justicia.
Discrecionalidad de la junta cantonal de protección de derechos y las medidas administrativas de protección
Authors: Palacios-Jurado Indira Estefanía , Castro-Sánchez Fernando-De-Jesús , Benalcázar-Guerrón Juan Carlos , Muñoz-Subía Katerine
Published: October 2022

Se procesó el objetivo discrecionalidad de la junta cantonal de protección de derechos y las medidas administrativas de protección. En cuanto al tipo de investigación es documental descriptivo con diseño bibliográfico. La importancia del principio de legalidad en el ámbito de aplicación de medidas de protección emergentes, en este caso las Juntas Cantonales de Protección de Derechos, al ser organismos administrativos deben sujetarse a este principio, pero en observancia de la normativa conexa y superior que motive cada una de las actuaciones.
Corpos (res) sentidos
Authors: Pinto Luiz Renato de Souza
Published: October 2022

Resenha de Corpos-sentidos, de Helena Arruda(Patuá, 2020).
THE PECULIAR REVELATIONS: SCROLLS PAINTINGS FROM THE WORLDS OF LUÓ PÌNG - 罗聘 (1733-1799)
Authors: Patron Ernesto Carlos Pujazon , Choon Woon Chong , Elias Jose Domingo
Published: October 2022

Since the early days of Homo Sapiens-Sapiens wandering the land, ghosts, spirits, and apparitions have dominated much of human existence. The goal of this two-part article is to offer a broader knowledge of the evolution of ghost-spirits from their early origins, as well as to analyse the many qualities of them and their interaction within the Chinese artwork of Luó Pìng - 罗聘 (1733-1799). The first section discusses the artist's historical background, his symbolic interpretations of themes and techniques, and his portrayal of the afterlife. The second section of this study concentrates on and provides several evidences of the Chinese philosophical background of death and life as well as the Ghost (Guǐ - 鬼) definition within the Chinese philosophy. Finally, this study concludes with a brief assessment of the artist's work, its cultural background, and its psychological effects, - a journey that captivates the fancies of every generation across different continents-.
Personal Hygiene dengan Kejadian Demam Tifoid
Authors: Betan Abubakar , Badaruddin Badaruddin , Fatmawati Fatmawati
Published: October 2022

Pendahuluan: Demam typoid erat kaitannya dengan higiene perorangan, higiene makanan, lingkungan yang kumuh, kebersihan tempat umum yang kurang serta perilaku masyarakat yang tidak mendukung untuk hidup sehat.
Tujuan: Mengetahui hubungan personal hygiene dengan kejadian demam tifoid.
Metode: Desaib penelitian ini peneliti menggunakan rancangan penelitian deskriptif analitik dengan jumlah sampel sebanyak 20 orang.
Hasil: Uji statistic menunjukkan bahwa kebersihan diri p-value: 0,001, mencuci nilai p-Value: 0,010 dan tingkat pengetahuan masyarakat (0,001).
Kesimpualan: Bahwa terdapat hubungan kebersihan diri, mencuci dan tingkat pengetahuan masyarakat dengan kejadian demam tifoid. Oleh karena itu, bagi petugas kesehatan dapat melakukan pencegahan dan penanggulangan penyakit demam tifoid di masyarakat.
Polarization Re-Configurable Antenna with Increase Gain for Small Satellites
Authors: Khalil Ruhul Amin , Haris Mohammad , Saeed Nasir
Published: October 2022

Future small satellites require the development of
reconfigurable antennas. Designing such antennas, especially
single port patch antennas with circular polarization (CP) is
a challenging task. Therefore, we propose both right-hand/left-
hand circularly polarized (RHCP/LHCP) antenna which can
reconfigure. The proposed antenna follows patch topology with
E-shape that is single-layer and single-feed with two RF switches.
The switches can alter the polarization in real-time. We also show
various properties of the proposed antenna, such as radiation
pattern, impedance matching, axial ratio, and bandwidth through
simulations and measurements. The proposed model shows excellent performance and agrees well with the measurements. The
performance of the antenna shows an effective bandwidth of 2.45
GHz to 2.82 GHz with a maximum gain of 9.88 dB at 2.55 GHz.
The symmetry of the antenna radiation is preserved by switching
between the LHCP and RHCP polarization modes.
Theory and Applications in Biomedical Engineering after Discovering a New Human Organ “Interstitium”
Authors: Wang Johnson
Published: October 2022

Traditional Chinese Medicine (TCM) is based on the physiological concept that life is supported by the continuous and all-pervading flow of energy named Chee. This concept has a logic deficiency that has handicapped TCM from entry into modern sciences in spite of the fact that it has been in practice since 2700 BC. In March 2018, the “Interstitium” was formally reported as a newly discovered organ that pervades the entire human body. This author believed that Interstitium as reported could cure TCM’s logic deficiency, thus started a small research program in July. By latching onto Interstitium, and distilling and synthesizing TCM procedures to conform to modern sciences, we have transformed TCM to a modern empirical science. We have also formulated a theory of Chee to enable TCM to be a full-fledged Scientific TCM (STCM). The method and procedure employed in developing this theory are similar to those taken by Julius Stratton in formulating classical macroscopic electromagnetic theory discussed in his book of 1941. Potential biomedical applications for STCM are many, including mental illnesses, inflammation, allergy, and infectious diseases. Since reported results are preliminary and lack independent verification, global collaborative efforts, both technical and business, are earnestly solicited openly  
The assessment of the forced sale value in the Italian residential market
Authors: Di Liddo Felicia , Tajani Francesco , Amoruso Paola , Ranieri Rossana , Anelli Debora
Published: October 2022

The present research has focused on the development and experimentation of a model for the forced sale value determination. With reference to six study samples consisting of residential properties sold through judicial auctions between November 2020 and May 2021 and each of them located in an Italian region, the forced sale price, the market value assessed by a judicial valuer and the main influencing factors have been detected. The implementation of an econometric technique has allowed to obtain models for the forced sale value assessment and for the analysis of the factors that mostly influence the final hammer price and, therefore, the discount between the market value evaluated and the judicial price. In the context of the existing literature, the study represents the first attempt that proposes a quantification of the discount/premium coefficient based on the specific factors of the property, in order to provide a reliable assessment of the forced sale value.
Prognostic Role of Carcinoembryonic Antigen (CEA) in Colorectal Carcinoma
Authors: Iftikhar Muhammad , Basit Abdul , Uddin M. Bilal , Ullah Zia , Sarwar Nayab , Aslam Rashid
Published: October 2022

Background: Preoperative carcinoembryonic antigen (CEA) level is considered as a factor predictive of survival in colorectal cancer patients. Patients with normal (<5 ng/ml) or lower pre- operative CEA levels were reported to have significantly longer survival. Objective: To evaluate the prognostic significance of preoperative CEA levels of patients with colorectal cancer in Taiwan. Methods: Between Jan 2016 and Dec 2017, 39 patients with histologically confirmed colorectal cancers were evaluated retrospectively at the General Surgery Department of Hayatabad Medical Complex Peshawar. All patients had undergone potentially curative surgery. Patients with metastatic diseases were not included. 5-Fluorouracil-based adjuvant chemotherapy was administered if the patients had Dukes’ C disease. Reference to the Dukes’ classification was according to the classical criteria described in 1932 for carcinoma of the rectum and adapted for use in colonic tumors. Data on gender, age, degree of tumor differentiation, location of the tumor, tumor size, lymph node metastasis, penetration of the bowel wall and preoperative CEA levels were analyzed to deter mine their association with survival. Blood samples for CEA measurement were taken a few days before operation and were analyzed using the radioimmunoassay method. Results: Total 39 patients were included in the study. Age ranged between 30-80 years with a mean age of 55 years. There were 26(66.7%) males and 13(33.3%) females, with male to female ratio of 2:1. Patients with preoperative CEA levels of <5 ng/ml had significantly longer survival than those with preoperative CEA levels of >5 ng/ml. The median 5 years survival rate for patients with preoperative CEA <5 ng/ml was 51.2 months, while 35.5 years for >5 ng/ml patients respectively (p < 0.001). The tumour was primary located at the colon in 23(59%) while the rest was found at the rectum 16(41%). Tumour size was <2cm in 25(64.1%) and >2cm in 14(35.9%) patients. ...............
A kommunikatív cselekvés szimbolikus és normatív háttere
Authors: Incze E. Rebeka
Published: October 2022

A társadalmi újratermelés strukturális vizsgálatánál Habermas különös jelentőséget tulajdonít a cselekvéskoordinációk nyelvi közegbe ágyazódó dinamikájának. A nyelv szimbolikus és normatív szerkezetére vonatkozó kérdésfelvetései mindenekelőtt G. H. Mead, valamint E. Durkheim koncepcióira támaszkodnak olyan kulcsfogalmak mentén, mint a szimbolikusan közvetített interakciók meadi fogalma, valamint a morál szakrális gyökerének és a kollektív tudatnak a durkheimi fogalmai.
Igazság, nyelv, filozófia: bevezetés a nyelvfilozófia rejtelmeibe
Authors: Ilyés Zalán-György
Published: October 2022

Gergely P. Alpár: Az asszerció beszédaktusának szemantikai és pragmatikai vizsgálata. Egyetemi Műhely Kiadó ‒ Bolyai Társaság, Kvár 2020. 163 old.
Képek találkozása a filmművészetben
Authors: Gregus Zoltán
Published: October 2022

Fám Erika: Viszontképek a filmben. Képfilozófiai, képelméleti és médiafilozófiai megközelítés. Pro Philosophia – Egyetemi Műhely, Kvár, 2020. 276 old.
A filozófia amnéziája : A létfelejtés heideggeri téziséről
Authors: Petki Pál
Published: October 2022

A heideggeri gondolatvilágban csak valamennyire is járatosak számára a filozófiával összefüggésben felhozott létfelejtés tézise jobbára evidenciának számít. Ebben az írásban ennek gondolati hátterébe és egyes filozófiatörténeti mozzanataiba való belegondolásra vállalkozunk, felhasználva a kérdésben relevánsnak számító, Heidegger különböző írásaiból származó megállapításokat. A jelzett evidencia ellenére ezt a próbálkozást az indokolhatja, hogy úgy véljük, az elsősorban a létfelejtés heideggeri gondolatának tényére és nem feltétlenül annak különböző jelentésösszetevőire, mondhatni tulajdonképpeni mibenlétére érvényes, következésképpen az itt következő fejtegetések adalékul szolgálhatnak ennek a filozófia történeti mozgása sajátosságára (is) vonatkozó heideggeri gondolatnak az értelmezéséhez.
Paresthesia of the inferior alveolar nerve caused by periapical pathology: case report
Authors: Ismailov F. R. , Khabadze Z. S.
Published: October 2022

Paresthesia in the chin area may not always be caused by a neurological condition. Sometimes persistent and prolonged treatment of the trigeminal nerve for neuralgia, does not have a positive result. One cause of mandibular numbness may be caused by compression on the mandibular canal by an odontogenic cyst.

Aim. To demonstrate the clinical symptomatology and radiological signs of mandibular nerve damage in a 48-year-old patient who underwent re-treatment of the lower left seventh tooth in 2 visits with long-term clinical and radiological follow-up.
perkembangan Motorik Kasar Melalui Permainan Lompat Tali Pada Anak Kelompok A Di Lembaga Ra Al-Istiqomah Gsi
Authors: Agustiani Siti , Kurniawati Rini , Rohmah Siti , Hataul Santy , Naruvita Sary Rina , Sudarya Agus
Published: October 2022

Good and correct gross motor stimulation can lead children to achieve optimal development. Unfortunately, many children whose gross motor skills have not developed optimally, this is because in learning teachers tend to use the lecture method so that children are less involved and do not practice directly to develop gross motor skills. Through the game of jumping rope, in addition to training cooperation and understanding, jumping rope will also demand the child's brain and body to maximize performance and movement. So that it will make good and perfect growth and development between intelligence and movement in the face of obstacles and problems. The method used in this research is the classroom action research method. The subjects involved in this study were 23 students of group A at RA Al-Istiqomah GSI, Griya Serdang Indah B, Margatani Village, Kramatwatu District, Serang Regency, Banten. The final result of the study showed that 96% of children developed very well in gross motor skills. Through the game of jumping rope, children's gross motor skills are well stimulated.
PENGARUH SUBSTITUSI TEPUNG BIT PADA PEMBUATAN BROWNIES KUKUS TERHADAP DAYA TERIMA KONSUMEN
Authors: Salsabila Safira , Riska Nur , Rusilanti Rusilanti
Published: October 2022

Beet flour is used in the manufacture of steamed brownies to be an alternative as a natural dye, to increase the variety of beet flour products, to reduce the use of wheat flour, and to use beet flour as a functional local food. This study aims to study and analyze the effect of beet flour substitution in the manufacture of steamed brownies on the physical quality and consumer acceptance. This research was conducted at the Pastry and Bakery Processing Laboratory of the Culinary Education Study Program, State University of Jakarta. The time of the research starts from July 2021 to June 2022. The method used in this study is an experimental method. The research sample used was steamed brownies with beet flour substitution as much as 35%, 45% and 55%, then tested on 30 untrained panelists who assessed all aspects. Based on the results of statistical hypothesis testing using the Friedman test, it shows that in all aspects there is no effect of substitution of beet flour as much as 35%, 45% and 55% in steamed brownies on consumer acceptance in terms of color, aroma, sweet taste, beet taste, texture, moistness, and pores. The conclusion of this study is to recommend steamed brownies with 55% beet flour substitution to be developed because it is liked by consumers and optimizes the use of beet flour as a functional local food.
Detection of Fake Job Advertisements using Machine Learning algorithms
Authors: E. Baraneetharan
Published: October 2022

Most companies nowadays use digital platforms to host conferences, job interviews, and other business events. The unexpected increase in the need for internet platforms has resulted in a rapid rise of fraud advertising. The agencies as well as fraudsters recruit the job seekers using a variety of techniques, including sources from online job-providing websites. By applying Machine Learning algorithms, researchers aim to decrease the number of such fraudulent and fake attempts. In this article, classifiers such as K-Nearest Neighbour, Support Vector Machine, and Extreme Gradient Boosting algorithms are implemented for fake advertisement prediction. The performances of the machine learning algorithms are evaluated using metrics such as accuracy, F1 measures, precision and recall.
Effective Approach for Early Detection of Diabetes by Logistic Regression through Risk Prediction
Authors: K. Thangarajan
Published: October 2022

Heart disease, cancer, renal failure, eye damage, and blindness are just some of the complications that may result from uncontrolled diabetes. Scientists are inspired to develop a Machine Learning (ML) approach for diabetes forecasting. To improve illness diagnosis, medical personnel must make use of ML algorithms. Different ML algorithms for identifying diabetes risk at an early stage are examined and contrasted in this research. The goal in analysing diabetes prediction models is to develop criteria for selecting high-quality studies and synthesising the results from several studies. Nonlinearity, normality, correlation structure, and complexity characterise the vast majority of medical data, making analysis of diabetic data a formidable task. Algorithms based on machine learning are not permitted to be used in healthcare or medical imaging. Early diabetes mellitus prediction necessitates a strategy distinct from those often used. Diabetic patients and healthy individuals may be separated using a risk stratification approach based on machine learning. This study is highly recommended since it reviews a variety of papers that may be used by researchers working on diabetes prediction models.
Design of an Ethereum Security Analysis for Unpredictable State System - An Overview
Authors: C. Anand
Published: October 2022

As a powerful tool for building framework and autonomous system across various domains, smart contracts are used to maintain security analysis in a better way. However, owing to the decentralised structure of the blockchain on which they are built, a number of concerns have surfaced about weaknesses in their programming, that according to their unique characteristics, might have (and have already had) a very large economic effect. This essay surveys the whole scope of smart contract security issues and the cutting edge of freely accessible security software.
Smart Home Energy Monitoring and Energy Reduction Technique
Authors: G. Rajakumar
Published: October 2022

The concept of Home Energy Management System (HEMS) is emerged from the development of smart homes, which connect humans and things to automate the manual operations. The smart homes users enjoy secured, pleasant, and autonomously managed lifestyle. Additionally, smart homes have the potential to generate revenue by vending clean and sustainable energy to the grid, thereby saving both energy and money. The proposed method efficiently reschedules and arranges the power flow among grid electricity, storage devices, and photovoltaic models to manage the energy requirements of smart home. Energy-management systems is highly preferred to economic benefits of smart homes while maintaining a comfortable living, maximizing connectivity and developing optimized operation of loads. The proposed system is finally implemented in a simulation environment, and further the obtained outcomes demonstrate the efficiency of the proposed method in terms of energy management from various sources.
О ПОДХОДЕ К МОДЕЛИРОВАНИЮ ЭТНОСОЦИАЛЬНЫХ РАЗЛИЧИЙ НА ОСНОВЕ СРАВНИТЕЛЬНОГО АНАЛИЗА ЯЗЫКОВЫХ СТРУКТУР
Authors: Перевозчиков С.В.
Published: October 2022

В статье рассматривается возможность моделирования этносоциальных различий на основе сравнительного анализа структур соответствующих языков. На примере русского, английского и чеченского языков демонстрируется, что результаты, полученные на основе такого анализа в отношении систем ценностей этносоциальных общностей, сопоставимы с результатами, выявленными с использованием социологических опросов и других социологических методов. Делается вывод о перспективах развития данного метода для социальных наук.
ГЕОДЕМОГРАФИЧЕСКАЯ ОБСТАНОВКА В БЕЛАРУСИ В РАЗРЕЗЕ ФУНКЦИОНАЛЬНО-ПЛАНИРОВОЧНЫХ РАЙОНОВ
Authors: Сидорович А.А.
Published: October 2022

В статье на основе данных переписей населения за период 1989 – 2019 гг. представлены региональная динамика и оценка воздействия миграционного фактора на формирование демографической ситуации в Беларуси в разрезе административно-территориальных районов различных функционально-планировочных типов. Установлено, что роль миграции в снижении численности населения возрастает по мере усиления значения аграрного сектора экономики в обеспечении занятости и формировании добавленной стоимости.