bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunomodulatory drugs have divergent effects on humoral and cellular immune responses to SARS-CoV-2 vaccination in people living with rheumatoid arthritis
Authors: Benoit Jenna M. , Breznik Jessica A. , Ang Jann C. , Bhakta Hina , Huynh Angela , Cowbrough Braeden , Baker Barbara , Heessels Lauren , Lodhi Sumiya , Yan Elizabeth , Ewusie Joycelyne , Nazy Ishac , Bramson Jonathan , Miller Matthew S. , Bernatsky Sasha , Larché Maggie J. , Bowdish Dawn M. E. ,   the SUCCEED Investigator Group
Published: December 2023

Understanding the efficacy of SARS-CoV-2 vaccination in people on immunosuppressive drugs, including those with rheumatoid arthritis (RA), is critical for their protection. Vaccine induced protection requires antibodies, CD4+ T cells, and CD8+ T cells, but it is unclear if these are equally affected by immunomodulatory drugs. Here, we determined how humoral and cellular SARS-CoV-2 vaccination responses differed between people with RA and controls, and which drug classes impacted these responses. Blood was collected from participants with RA on immunomodulatory drugs and controls after their second, third, and fourth SARS-CoV-2 vaccinations. Receptor binding domain (RBD)-specific antibodies were quantified by ELISA. Spike-specific memory T cells were quantitated using flow cytometry. Linear mixed models assessed the impact of age, sex, and immunomodulatory drug classes on SARS-CoV-2 vaccination responses. Compared to non-RA controls (n = 35), participants with RA on immunomodulatory drugs (n = 62) had lower anti-RBD IgG and spike-specific CD4+ T cell levels, but no deficits in spike-specific CD8+ T cells, following SARS-CoV-2 vaccination. Use of costimulation inhibitors was associated with lower humoral responses. JAK inhibitors were associated with fewer spike-specific CD4+ T cells. Participants with RA on immunomodulatory drugs mounted weaker responses to SARS-CoV-2 vaccination, with different drug classes impacting the cellular and humoral compartments.
Anthelmintic efficacy evaluation and mechanism of N-methylbenzo[d]oxazol-2-amine
Authors: Prangthip Pattaneeya , Tummatorn Jumreang , Adisakwattana Poom , Uthailak Naphatsamon , Boonyuen Usa , Tipthara Phornpimon , Tarning Joel , Laohapaisan Pavitra , Thongsornkleeb Charnsak , Ruchirawat Somsak , Reamtong Onrapak
Published: December 2023

Parasitic roundworms cause significant sickness and mortality in animals and humans. In livestock, these nematodes have severe economic impact and result in losses in food production on a global scale. None of the currently available drugs ideally suit all treatment circumstances, and the development of drug-resistant nematode strains has become a challenge to control the infection. There is an urgent need to develop novel anthelmintic compounds. According to our previous report, N-methylbenzo[d]oxazol-2-amine (1) showed anthelmintic activity and lowest cytotoxicity. In this study, in vivo anthelmintic properties were evaluated using Trichinella spiralis infected mice. Toxicity was evaluated using the rats and mode of action using molecular docking and metabolomics approaches. The in vivo results demonstrate that a dose of 250 mg/kg reduced the T. spiralis abundance in the digestive tract by 49%. The 250 mg/kg Albendazole was served as control. The relatively low acute toxicity was categorized into chemical category 5, with an LD50 greater than 2000 mg/kg body. Molecular docking analysis showed the T. spiralis tubulin beta chain and glutamate-gated channels might not be the main targets of compound 1. Metabolomics analysis was used to explain the effects of compound 1 on the T. spiralis adult worm. The results demonstrated that compound 1 significantly up-regulated the metabolism of purine, pyrimidine and down-regulated sphingolipid metabolism. In conclusion, compound 1 could be a potential molecule for anthelmintic development. The bioavailability, pharmacokinetics, and absorption of this compound should be studied further to provide information for its future efficacy improvement.
Immuno-SPR biosensor for the detection of Brucella abortus
Authors: Pasquardini Laura , Cennamo Nunzio , Arcadio Francesco , Perri Chiara , Chiodi Alessandro , D’agostino Girolamo , Zeni Luigi
Published: December 2023

A proof of principle biosensor for the Brucella abortus recognition onsite is presented. The system is based on a plasmonic optical fiber probe functionalized with an oriented antibody layer immobilized on a short polyethyleneglycol (PEG) interface through carbodiimide chemistry and protein G as an intermediate layer. The biosensor is inserted in a holder built in 3D printing technology, obtaining a custom holder useful for housing the sample to be measured and the equipment. The removable sensor chip is a low-cost Surface Plasmon Resonance (SPR) platform based on D-shaped plastic optical fibers (POFs), built-in in 3D printed connectors, used here for the first time to detect bacteria via a bio-receptor layer specific for its membrane protein. The performances of the biosensor in Brucella abortus recognition are tested by using two different SPR-POF probes combined with the same bio-receptor layer. The best sensor configuration has presented a sensitivity at low concentrations of one order of magnitude greater than the other. A limit of detection (LoD) of 2.8 bacteria/mL is achieved well competitive with other systems but without the need for amplification or special sample treatments. Specificity has been tested using Salmonella bacteria, and reproducibility, regenerability and stability are moreover evaluated. These experimental results pave the way for building an efficient and specific biosensor system for Brucella abortus detection onsite and in a few minutes. Moreover, the proposed POF-based SPR biosensor device, with respect to the already available technologies, could be a Point-of-care-test (POCT), simple to use, small-size and portable, low-cost, don’t necessary of a microfluidic system, and can be connected to the Internet (IoT).
The impact of digital economy on green total factor productivity considering the labor-technology-pollution factors
Authors: Huang Yipeng , Chen Zhiguo , Li Huiru , Yin Shi
Published: December 2023

The digital economy provides new impetus for the high-quality development of manufacturing industry. Through the DEA-Malmquist model and panel regression model, this paper confirmed that there is a positive and significant relationship between the development of digital economy and the green total factor productivity (GTFP) of manufacturing industry. The research result is as follows: (1) the development of digital economy can enhance the overall GTFP of manufacturing industry. (2) The green technology progress brought by the development of digital economy is the main path to promote the GTFP of manufacturing industry. (3) The heterogeneity analysis shows that the impact of digital economy on GTFP of high pollution manufacturing industry is significantly positive, the impact of labor-intensive manufacturing industry is significantly negative, and the impact of technology intensive manufacturing industry is not obvious. The contributions of this study are as follow. In terms of theory, this study theoretically continues Solow’s classical theory, demonstrating the scientific nature of digital technology progress in promoting GTFP growth. In empirical analysis, this study build a new digital economy development level evaluation index system based on the perspective of manufacturing industry. In addition, this study also add a labor-technology-pollution perspective for the development of relevant policies.
Exogenous moisture deficit fuels drought risks across China
Authors: Wang Gang , Zhang Qiang , Pokhrel Yadu , Farinotti Daniel , Wang Jida , Singh Vijay P. , Xu Chong-Yu
Published: December 2023

Intensifying droughts under climatic warming are of widespread concern owing to their devastating impacts on water resources, societies and ecosystems. However, the effects of exogeneous drivers on regional droughts remain poorly understood. Using the Lagrangian method, atmospheric reanalysis data and climate projections from the Coupled Model Inter-comparison Project phase 6 (CMIP6), we show how exogenous precipitation minus evaporation (PME) deficit drives droughts across China. More specifically, we demonstrate that four distinct trajectories of such exogenous PME deficit fuel regional droughts. Three of these trajectories relate to oceanic PME deficit originating from the North Atlantic, eastern Bering Sea and Indian Ocean, and one trajectory characterizes exogenous terrestrial PME deficit from the Siberian Plateau. We show that during 1980–2020, droughts induced by exogenous PME deficit account for 45% of all droughts that occurred in China’s coastal region, and for 7% of all droughts in the northwestern regions. Under climate scenario SSP245 (SSP585), limiting warming to 1.5 °C compared to 2 °C above pre-industrial levels could avoid 60% (84%) of exogenous drought exposure. This would in turn reduce population exposure by 40% (49%), and economic exposure by 73% (66%). Our study unravels how exogenous PME deficit drives droughts in China, underscoring the role that external drivers have on regional droughts and associated future prediction.
Chromatin regulator SMARCAL1 modulates cellular lipid metabolism
Authors: Nagai Taylor Hanta , Hartigan Chrissy , Mizoguchi Taiji , Yu Haojie , Deik Amy , Bullock Kevin , Wang Yanyan , Cromley Debra , Schenone Monica , Cowan Chad A. , Rader Daniel J. , Clish Clary B. , Carr Steven A. , Xu Yu-Xin
Published: December 2023

Biallelic mutations of the chromatin regulator SMARCAL1 cause Schimke Immunoosseous Dysplasia (SIOD), characterized by severe growth defects and premature mortality. Atherosclerosis and hyperlipidemia are common among SIOD patients, yet their onset and progression are poorly understood. Using an integrative approach involving proteomics, mouse models, and population genetics, we investigated SMARCAL1’s role. We found that SmarcAL1 interacts with angiopoietin-like 3 (Angptl3), a key regulator of lipoprotein metabolism. In vitro and in vivo analyses demonstrate SmarcAL1’s vital role in maintaining cellular lipid homeostasis. The observed translocation of SmarcAL1 to cytoplasmic peroxisomes suggests a potential regulatory role in lipid metabolism through gene expression. SmarcAL1 gene inactivation reduces the expression of key genes in cellular lipid catabolism. Population genetics investigations highlight significant associations between SMARCAL1 genetic variations and body mass index, along with lipid-related traits. This study underscores SMARCAL1’s pivotal role in cellular lipid metabolism, likely contributing to the observed lipid phenotypes in SIOD patients.
Atomistic ensemble of active SHP2 phosphatase
Authors: Anselmi Massimiliano , Hub Jochen S.
Published: December 2023

SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause developmental disorders and are linked to hematological malignancies and cancer. SHP2 comprises two tandemly-arranged SH2 domains, a catalytic PTP domain, and a disordered C-terminal tail. Under physiological, non-stimulating conditions, the catalytic site of PTP is occluded by the N-SH2 domain, so that the basal activity of SHP2 is low. Whereas the autoinhibited structure of SHP2 has been known for two decades, its active, open structure still represents a conundrum. Since the oncogenic mutant SHP2E76K almost completely populates the active, open state, this mutant has been extensively studied as a model for activated SHP2. By molecular dynamics simulations and accurate explicit-solvent SAXS curve predictions, we present the heterogeneous atomistic ensemble of constitutively active SHP2E76K in solution, encompassing a set of conformational arrangements and radii of gyration in agreement with experimental SAXS data.
Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma
Authors: Munawar Umair , Zhou Xiang , Prommersberger Sabrina , Nerreter Silvia , Vogt Cornelia , Steinhardt Maximilian J. , Truger Marietta , Mersi Julia , Teufel Eva , Han Seungbin , Haertle Larissa , Banholzer Nicole , Eiring Patrick , Danhof Sophia , Navarro-Aguadero Miguel Angel , Fernandez-Martin Adrian , Ortiz-Ruiz Alejandra , Barrio Santiago , Gallardo Miguel , Valeri Antonio , Castellano Eva , Raab Peter , Rudert Maximilian , Haferlach Claudia , Sauer Markus , Hudecek Michael , Martinez-Lopez J. , Waldschmidt Johannes , Einsele Hermann , Rasche Leo , Kortüm K. Martin
Published: December 2023

The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated into routine treatment algorithms, resulting in improved response rates. Nevertheless, patients continue to relapse and the underlying mechanisms of resistance remain poorly understood. While Impaired death receptor signaling has been reported to mediate resistance to CART in acute lymphoblastic leukemia, this mechanism yet remains to be elucidated in context of novel immunotherapies for MM. Here, we describe impaired death receptor signaling as a novel mechanism of resistance to T-cell mediated immunotherapies in MM. This resistance seems exclusive to novel immunotherapies while sensitivity to conventional anti-tumor therapies being preserved in vitro. As a proof of concept, we present a confirmatory clinical case indicating that the FADD/BID axis is required for meaningful responses to novel immunotherapies thus we report impaired death receptor signaling as a novel resistance mechanism to T-cell mediated immunotherapy in MM.
Optimal tagging strategies for illuminating expression profiles of genes with different abundance in zebrafish
Authors: Liu Jiannan , Li Wenyuan , Jin Xuepu , Lin Fanjia , Han Jiahuai , Zhang Yingying
Published: December 2023

CRISPR-mediated knock-in (KI) technology opens a new era of fluorescent-protein labeling in zebrafish, a preferred model organism for in vivo imaging. We described here an optimized zebrafish gene-tagging strategy, which enables easy and high-efficiency KI, ensures high odds of obtaining seamless KI germlines and is suitable for wide applications. Plasmid donors for 3′-labeling were optimized by shortening the microhomologous arms and by reducing the number and reversing the sequence of the consensus Cas9/sgRNA binding sites. To allow for scar-less KI across the genome, linearized dsDNA donors with 5′-chemical modifications were generated and successfully incorporated into our method. To refine the germline screen workflow and expedite the screen process, we combined fluorescence enrichment and caudal-fin junction-PCR. Furthermore, to trace proteins expressed at a low abundance, we developed a fluorescent signal amplifier using the transcriptional activation strategy. Together, our strategies enable efficient gene-tagging and sensitive expression detection for almost every gene in zebrafish.
Efficiency limit of transition metal dichalcogenide solar cells
Authors: Nassiri Nazif Koosha , Nitta Frederick U. , Daus Alwin , Saraswat Krishna C. , Pop Eric
Published: December 2023

Ultrathin transition metal dichalcogenide (TMD) films show great promise as absorber materials in high-specific-power (i.e., high-power-per-weight) solar cells, due to their high optical absorption, desirable band gaps, and self-passivated surfaces. However, the ultimate performance limits of TMD solar cells remain unknown today. Here, we establish the efficiency limits of multilayer (≥5 nm-thick) MoS2, MoSe2, WS2, and WSe2 solar cells under AM 1.5 G illumination as a function of TMD film thickness and material quality. We use an extended version of the detailed balance method which includes Auger and defect-assisted Shockley-Read-Hall recombination mechanisms in addition to radiative losses, calculated from measured optical absorption spectra. We demonstrate that single-junction solar cells with TMD films as thin as 50 nm could in practice achieve up to 25% power conversion efficiency with the currently available material quality, making them an excellent choice for high-specific-power photovoltaics.
Weak signal extraction in non-stationary channel with weak measurement
Authors: Song Qi , Li Hongjing , Huang Jingzheng , Huang Peng , Tan Xiaorui , Tao Yu , Shi Chunhui , Zeng Guihua
Published: December 2023

An emerging challenge of integrated communication and sensing is the extraction of weak sensing signals transmitted through an unknown non-stationary channel. In this work, we propose a weak signal extraction method with weak measurement. Taking advantage of time division multiplexing, we preliminarily estimate the channel via adjustable finite impulse response filter, further suppressing the interfering signal caused by background noises via spectrum shift. By subsequently using the time-varying phase estimation method via weak measurement, the real-time detection of weak signals in the non-stationary channel is achieved. We demonstrate via theoretical analysis and confirmatory experiment that our method is able to amplify the phase shift, to suppress technical noise and to improve detection resolution limit, while proving robust against light source fluctuations, initial phase differences and detector saturation. The method hence enables weak sensing signal extraction with a low signal-to-noise ratio non-stationary channel. Furthermore, we interface our measurement method to squeezed light sources, offering the possibility of surpassing standard quantum limit.
Nonlinear electrical transport phenomena as fingerprints of a topological phase transition in ZrTe5
Authors: Salawu Yusuff Adeyemi , Adhikari Dilanath , Kim Jin Hee , Rhyee Jong-Soo , Sasaki Minoru , Kim Ki-Seok , Kim Heon-Jung
Published: December 2023

Topological phase transitions, influenced by magnetic fields, dopants, pressure, and temperature, create Berry curvature in band structures, challenging to detect due to resolution and scattering issues in spectroscopy and transport. Here, we propose nonlinear electrical transport phenomena as fingerprints of a topological phase transition in ZrTe5 under magnetic fields. Both a nonlinear longitudinal conductivity ΔσL in a magnetic-field-aligned electric field and a third-order nonlinear Hall (transverse) conductivity Δσxy in a magnetic-field-perpendicular electric field arise below a characteristic temperature T*. The sensitivity of nonlinear transport to the band topology allows the detection of a subtle change in the band topology hidden in linear transport coefficients. Extending the previous scaling theory between linear transport coefficients (σxx and σxy), we also propose scaling relations for both linear (σxx and σxy) and nonlinear (ΔσL and Δσxy) transport coefficients. These scaling relations will help understand the interplay between the mechanisms of nonlinear transport coefficients and the influence of Berry curvature.
Biochar-plant interactions enhance nonbiochar carbon sequestration in a rice paddy soil
Authors: Liu Zhiwei , Zhang Wei , Ma Ruiling , Li Shixian , Song Kaiyue , Zheng Jufeng , Wang Yan , Bian Rongjun , Zhang Xuhui , Pan Genxing
Published: December 2023

Soil amendment with biochar is being promoted as a promising strategy for carbon (C) stabilization and accrual, which are key to climate change mitigation. However, it remains elusive on how biochar addition influences nonbiochar C in soils and its mechanisms, especially in the presence of plants. Here we conducted a 365-day soil microcosm experiment with and without adding 13C-labeled biochar into topsoil to quantify changes in nonbiochar C in the topsoil and subsoil in the presence or absence of rice plants and to determine the mechanisms by which biochar controls nonbiochar C accrual in the soil profile. The nonbiochar C content of topsoil was not affected by biochar addition in the absence of rice plants, but was significantly increased by 4.5% in the presence of rice plants, which could result from increases in the soil macroaggregate fraction, iron (Fe)-bound nonbiochar organic C content, and fungal biomass collectively. However, biochar amendment had no effect on the content of nonbiochar organic C in the subsoil. Overall, biochar-plant interactions drive more nonbiochar C sequestration in the topsoil, and the changes of nonbiochar C in planted soils following biochar addition should be quantified to better assess the soil C sequestration potential in agricultural lands.
Metabolomics-derived biomarkers for biosafety assessment of Gd-based nanoparticle magnetic resonance imaging contrast agents
Authors: Xu Chen , Sun Jie , Zhang Chenhao , Yang Lu , Kan Hong , Zhang Daguang , Xue Guan , Dong Kai
Published: December 2023

We employed an ultra-high performance liquid chromatography–electrospray ionization quadrupole time-of-flight mass spectrometry-based metabolomics approach to investigate the potential toxicity of Gd-based nanoparticle MRI contrast agents.
Cell membrane-coated biomimetic nanomedicines: productive cancer theranostic tools
Authors: Ijaz Muhammad , Aslam Bilal , Hasan Ikram , Ullah Zia , Roy Shubham , Guo Bing
Published: December 2023

Illustration shows the various sources of cell membrane along with different NPs used for the production of cell membrane-coated nanoparticles and their applications.
Engineered triphenylphosphonium-based, mitochondrial-targeted liposomal drug delivery system facilitates cancer cell killing actions of chemotherapeutics
Authors: Sivagnanam Subramaniyam , Das Kiran , Pan Ieshita , Stewart Adele , Barik Atanu , Maity Biswanath , Das Priyadip
Published: December 2023

Lip-DT represents an important proof-of-concept exercise demonstrating that functionalized PCDA/DMPC-based liposomes have great promise for the development of new imaging probes and targeted drug-delivery vehicles.
Solvent-controlled halohydroxylation or C3–C2 coupling of pyridinium salts through an interrupted dearomative reduction
Authors: Zhang Congcong , Chen Qinhao , Qin Yunlong , Bu Zhanwei , Wang Qilin
Published: December 2023

Herein, we report a solvent-controlled halohydroxylation or C3–C2 coupling of pyridinium salts through an interrupted dearomative reduction.
The crystal structure of hexaphenylbenzene under high hydrostatic pressure
Authors: Turner Gemma F. , Stapleton Nicholas , Brookes James , Spagnoli Dino , Sussardi Alif N. , Jones Anita C. , McGonigal Paul R. , Moggach Stephen A.
Published: December 2023

High-pressure single-crystal X-ray diffraction, intermolecular interaction energy calculations, and density functional theory are used to examine the structure and emission properties of hexaphenylbenzene during hydrostatic compression to 4.14 GPa.
Highly efficient iodine uptake and iodate selective probe in a 3D honeycomb-like copper–organic framework based on in situ ligand transformation
Authors: Dai Wen , Zhang Chuanming , Yang Xiaoang , Li Lincai
Published: December 2023

A 3D honeycomb-like copper-organic framework is fabricated by in situ ligand transformation. The novelty for this framework is in its remarkable uptake performance toward iodine vapor and selective sensitivity for recognizing the iodate anion.
The effect of charged particle irradiation on the transport properties of bismuth chalcogenide topological insulators: a brief review
Authors: S Abhirami , Amaladass E. P. , Amirthapandian S. , David C. , Mani Awadhesh
Published: December 2023

Topological insulators (TIs) offer a novel platform for achieving exciting applications, such as low-power electronics, spintronics, and quantum computation.
Exceptional metal–semiconductor–metal transition of lead apatites via oxygen defect tuning
Authors: Huang Zhijing , Ni Xiaojian , Huang Hao , Tu Yusong , Gu Zonglin , Zeng Shuming
Published: December 2023

The introduction of Oy defects prompts a remarkable transition in Pb10(PO4)6Oy from metal to semiconductor to metal, accompanied by pivotal shifts in the principal electronic contributors from p orbitals of Oy to those of Pb atoms.
N-Alkyl substituted triazenide-bridged homoleptic iron(ii) dimers with an exceptionally short Fe–Fe bond
Authors: Soussi Khaled , Jeanneau Erwann , Maldivi Pascale , Clémancey Martin , Latour Jean-Marc , Khrouz Lhoussain , Lorentz Chantal , Daniele Stéphane , Mishra Shashank
Published: December 2023

We synthesized novel homoleptic dimeric complexes of the general formula [Fe2(N3tBuR)4] (R = Et, iPr, nBu) having the shortest Fe(ii)–Fe(ii) bond (2.167–2.174 Å) reported to date and a low-spin ground state.
Unveiling the potential of a covalent triazine framework based on [1]benzothieno[3,2-b][1]benzothiophene (DPhBTBT-CTF) as a metal-free heterogeneous photocatalyst
Authors: Borrallo-Aniceto M. Carmen , Pintado-Sierra Mercedes , Valverde-González Antonio , Díaz Urbano , Sánchez Félix , Maya Eva M. , Iglesias Marta
Published: December 2023

A novel covalent triazine framework (DPhBTBT-CTF) prepared by microwave cyclotrimerization of BTBT units was proved as very versatile photocatalyst for different reactions: oxidations, bromination, Diels–Alder cycloaddition and hydroxylations.
Metal-free semiconductors for visible-light-induced carbocarboxylation of styrenes with aliphatic redox-active esters and CO2
Authors: Hou Hao , Luo Meizhen , Zhai Senmao , Yuan Tao , Zheng Meifang , Wang Sibo
Published: December 2023

A metal-free heterogeneous photoredox system provides a mild, sustainable, and practical route for the carboxyalkylation of olefins using ambient carbon dioxide as a C1 source and aliphatic reactive esters as building blocks.
Joule heating and electroosmotic flow in cellular micro/nano electroporation
Authors: Pan Junjie , Wang Xinyu , Chiang Chi-ling , Ma Yifan , Cheng Junao , Bertani Paul , Lu Wu , Lee L. James
Published: December 2023

Joule heating and electrokinetic phenomena in micro/nano-electroporation (MEP/NEP) is investigated. An ‘electroporation zone’ is defined for NEP/MEP to avoid the negative impact of Joule heating and electro-osmosis on cargo transport.
Scaling up the charge transfer on Pd@Ti3C2Tx–TiO2 catalysts: a sustainable approach for H2 generation via water splitting
Authors: Abid Muhammad Zeeshan , Rafiq Khezina , Rauf Abdul , Althomali Raed H. , Hussain Ejaz
Published: December 2023

The increasing energy demands have led modern societies to search for green and renewable alternatives. For this purpose, we have synthesized highly active MXene supported catalysts (Pd@Ti3C2Tx–TiO2).
Phenazine-integrated conjugated microporous polymers for modulating the mechanics of supercapacitor electrodes
Authors: Kotp Mohammed G. , Lüder Johann , Kuo Shiao-Wei , EL-Mahdy Ahmed F. M.
Published: December 2023

The current paper presents the rational synthesis of two novel conjugated microporous polymers (CMPs) based on different phenazine linkers displaying different storage mechanics which then modulating their capacitances.
Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents
Authors: G Vishakantegowda Avinash , Hwang Dasom , Chakrasali Prashant , Jung Eunhye , Lee Joo-Youn , Shin Jin Soo , Jung Young-Sik
Published: December 2023

The newly identified compound, 7f, is a selective inhibitor of PI4KIIIβ, and shows potent and broad-spectrum anti-hRV activity with low toxicity. The compound also shows potent anti-EV activity.
A supramolecular approach for converting renewable biomass into functional materials
Authors: Zhang Yunfei , Cai Changyong , Xu Ke , Yang Xiao , Yu Leixiao , Gao Lingyan , Dong Shengyi
Published: December 2023

A supramolecular approach was applied to construct functional materials from natural biomass.
Development and application of mass spectrometric molecular networking for analyzing the ingredients of areca nut
Authors: Zhao Jialiang , Shi Jiachen , Chen Xiaoying , Lei Yuanluo , Tian Tian , Zhu Shuang , Tan Chin-Ping , Liu Yuanfa , Xu Yong-Jiang
Published: December 2023

The development of an approach combining LC-MS and a feature-based molecular network for exploring the chemical composition of areca nut, which has a stronger annotation ability for unknown compounds.
Silver-integrated cobalt hydroxide hybrid nanostructured materials for improved electrocatalytic oxygen evolution reaction
Authors: Arunkumar Gunasekaran , Muthukumar Pandi , Deviga Govindan , Mariappan Mariappan , Pannipara Mehboobali , Al-Sehemi Abdullah G. , Anthony Savarimuthu Philip
Published: December 2023

Synthesizing Co(OH)2 with coexisting amorphous and crystalline phases showed strong electrocatalytic OER activity in the alkaline medium. The OER activity of Co(OH)2 was further improved upon the integration of AgNPs.
Carbon quantum dots (CQDs)-modified polymers: a review of non-optical applications
Authors: Latif Zeeshan , Shahid Kinza , Anwer Hassan , Shahid Raghisa , Ali Mumtaz , Lee Kang Hoon , Alshareef Mubark
Published: December 2023

CQD–polymer composite structure for enhanced self-healing and shape memory characteristics.
A Cu hollow fiber with coaxially grown Bi nanosheet arrays as an integrated gas-penetrable electrode enables high current density and durable formate electrosynthesis
Authors: Meng Zhe , Wang Fang , Zhang Zhengguo , Min Shixiong
Published: December 2023

An integrated gas-penetrable electrode was developed by coaxially growing high density Bi nanosheet arrays on a Cu hollow fiber, which can efficiently and stably catalyze CO2 reduction to formate (HCOO−) at high current density.
Tailoring the facet distribution on copper with chloride
Authors: Couce Pedro Mazaira , Madsen Thor Kongstad , Plaza-Mayoral Elena , Kristoffersen Henrik H. , Chorkendorff Ib , Dalby Kim Nicole , van der Stam Ward , Rossmeisl Jan , Escudero-Escribano María , Sebastián-Pascual Paula
Published: December 2023

Herein we combine voltammetric lead underpotential deposition and density function theory to determine the geometry of the active sites of copper surfaces modified with chloride.
Stability improvement of carbon-based electrodes in aqueous electrocapacitive devices
Authors: Li Jiayuan , Wang Ao , Tan Chang , Wu Dichao , Fan Mengmeng , Sun Kang , Jiang Jianchun , Boles Steven , Li Bei , Liu Junli
Published: December 2023

The employment of an oxygenated carbon cathode significantly alleviates the inversion effect and improves the stability of a capacitive deionization system.
In situ forming, mechanically resilient hydrogels prepared from 4a-[PEG-b-PTMC-Ac] and thiolated chondroitin sulfate for nucleus pulposus cell delivery
Authors: Riahinezhad Hossein , Amsden Brian G.
Published: December 2023

Intervertebral disk degeneration (IVDD) is a common condition that causes severe back pain and affects patients’ mobility and life quality considerably.
Research on the variation of dielectric properties of oil‐paper insulation for power equipment over a wide temperature range
Authors: Zhang Mingze , Yu Muhe , Zhou Wen , Liang Yilin , Lei Shengjie , Shi Yunbo , Qu Limin
Published: December 2023

The main part of oil‐immersed power equipment is oil‐paper insulation. At lower ambient temperatures, transformer oil will become viscous. As a result, compared to those at room temperature or operating temperature, the frequency domain dielectric properties of oil‐paper insulation at low temperatures are drastically different. For evaluating the insulation condition of electrical equipment, it is essential to accurately determine their dielectric properties. This paper described the FDS test, the DC conductivity test, and the transformer oil viscosity test, which was carried out in a laboratory environment for different ageing of oil‐immersed pressboard and transformer oil at 233–373 K. The effects of temperature on the dielectric properties at the competing mechanisms of polarisation and conductivity loss were clarified based on variations of the FDS curves. Considering the viscosity change of ageing transformer oil at low temperatures, the Arrhenius and VFT viscosity equations were used to achieve a fitting calculation in the different temperature zones. Based on the molecular/ion transition model in the force field and electric field, the characterisation relationships between the dynamic viscosity, DC conductivity, and test temperature of transformer oil were established. The limitations of conventional transformer oil equivalent dielectric relaxation models over a wide temperature range were finally clarified by combining the test findings of the DC conductivity over a wide temperature range with observed and simulated calculations. This paper provides an essential theoretical reference when using the FDS test to diagnose the insulation performance of oil‐immersed power equipment in extremely cold regions.
TIR‐YOLO‐ADAS: A thermal infrared object detection framework for advanced driver assistance systems
Authors: Ding Meng , Guan Song , Liu Hao , Yu Kuaikuai
Published: December 2023

An object detection framework using thermal infrared (TIR) cameras is proposed to meet the needs of an advanced driver assistance system (ADAS) operating at night‐time and in low‐visibility conditions. The proposed detection framework, referred to as TIR‐YOLO‐ADAS, is an improvement of YOLOX for TIR object detection in ADAS. First, to address the disadvantages of TIR objects, the part of the attention mechanism is designed to enhance the discriminative ability of feature maps in the spatial and channel dimensions. Second, a focal loss function is used as the confidence loss function to enable the framework to focus on detection tasks of difficult, misclassified targets in the process of network training. The results of the ablation experiment on the Forward‐looking infrared (FLIR) thermal ADAS dataset indicate that the proposed framework significantly improves the performance of TIR object detection. Comparative experimental results further show that TIR‐YOLO‐ADAS performs favourably when compared with three representative detection algorithms. To evaluate the practicality and feasibility of the proposed framework in various applications, a qualitative assessment in real road scenarios was conducted. The experimental results confirm that the proposed framework performs promisingly and could be integrated into vehicle platforms as an ADAS module.
Statistical analysis of the radar cross section of two small fixed‐wing drones using typical flights
Authors: Björklund Svante , Hernnäs Harald
Published: December 2023

The presence and importance of small drones (unmanned aerial vehicles) are increasing. With traditional radar detection the target radar cross section and its statistical properties are needed in order to design the detector and to assess detection performance. The authors make a statistical analysis of the radar cross section of two small fixed‐wing drones using measured data from typical flights. Using data from a typical flight instead of measurements or electromagnetic calculations as a function of aspect angle is a convenient method. Work results of the authors in mean values, medians and standard deviations, in analyses of common target probability distributions and in decorrelation times for the radar cross section, are necessary for design and assessment of the detection performance. The authors suggest a new target probability distribution which agrees better with the measured data than the others tested. The authors also note significant differences between the drones.
Effect of breakwater layout on waves at Puger beach Jember with Delft3D modeling
Authors: Utami Agung Wiyono Retno , Fadhilla Ardiasho , Royyan Maulana Ma A. , Halik Gusfan , Yunarni Widiarti Wiwik , Hidayah Entin
Published: December 2023

Puger Beach located in Puger Village, Jember Regency which is often passed by fishing boats to Puger Fish Market. The problem of high waves is often experienced by fishermen. In 2014, a breakwater was built in the estuary of Puger Beach to overcome the problem. However, the construction of the breakwater is considered not optimal because the layout of the building only dampens waves from the west. Based on this background, this study aims to model the sea waves that occur in the estuary of Puger Beach due to the influence of the breakwater layout. Waves were modeled based on the dominant wind direction at the study site: southwest, west, and south. Modeling was made using Delft3D software by creating five breakwater placement schemes. The modeling results obtained southwest, west, and south respectively are: the first scheme reduced the wave height by 31.01%, 27.33%, and 37%; the second scheme reduced the wave height by 28.95%, 31.59%, and 36.63%; the third scheme reduced the wave height by 78.12%, 82.08%, and 65.32%; the fourth scheme reduced the wave height by 79.91%, 47.28%, and 76.54%; the fifth scheme reduced the wave height by 94.53%, 99.78%, and 96.78%.
Rock Mass Characterizations and Kinematic Analysis for Construction Design Method of Diversion Tunnel of Dolok Dam, Central Java
Authors: Sandria Lutfie Arlan , Indrawan I. Gde Budi , Hendrayana Heru
Published: December 2023

Investigation of slope stability in the design of the tunnel portal is important to minimize slope failure. This research aims to describe the rock mass characterizations and classifications using Geological Strength Index (GSI) and Rock Mass Rating (RMR), along with the kinematic analysis and Slope Mass Rating (SMR) to define the risk of slope failure and the recommended support at the tunnel portal. Geological mapping and core evaluation were conducted to analyse the slope stability. The results show that the rock masses consist of intercalated rudstone with mudstone, typically have disintegrated, moderately disturbed, and blocky structures with slightly to highly weathered. The discontinuities have 3 – 4 sets consisting of bedding and joint, have medium to high persistence, close spacing, and dominantly have no infillings. These rock masses are classified as poor-fair rock in the upper part of the sequence, and good rock in the bottom part of the sequence. The kinematic analysis predicts the risk of toppling failure both in the inlet and outlet portal. The recommended support in the inlet portal is the combination of shotcrete, beams, and bolts, whilst in the outlet portal is the combination of surface drainage, shotcrete, dental concrete, beams, and bolts.
Assessment of post-liquefaction potential in soil displacement on irrigation canal reconstruction project in the Jono Oge and Lolu area, Central Sulawesi, Indonesia
Authors: Widyanata I. Made , Ismanti Sito , Setiawan Angga Fajar
Published: December 2023

A seismic event of magnitude 7.5 Mw took place in Central Sulawesi in September 2018, marking a significant occurrence in the geological hazard chronicles of Indonesia. The occurrence of liquefaction subsequent to the earthquake significantly damaged the water resource infrastructure in the Sigi Regency. This study aims to evaluate the possible soil displacement resulting from re-liquefaction events occurring in the main irrigation canals in the Jono Oge and Lolu regions. The study used semi-empirical and finite element analysis to compute the lateral displacement index and reconsolidation settlement within the designated study region. The examination of soil displacement is conducted under various groundwater level scenarios, utilizing the most recent soil investigation conducted in 2021. The findings of the study indicate that raising the groundwater level to -3.5 meters will result in significant soil and irrigation canal damage. In the future, it is suggested that limiting the groundwater level below -11 meters in the primary irrigation canal area might effectively mitigate soil lateral displacement and settlement.
Extreme Coastal Flood Inundation Mapping Based on Sentinel 1 Using Google Earth Engine
Authors: Wijayanti Estu , Nurfaida Wakhidatik , Fadhilah Sabilal Haque Laily , Ratna Mayangsari Wulan , Agus Salim Fuad , Iqbal Taftazani Muhammad
Published: December 2023

Coastal flooding frequently occurs along the Northern Coast of Java due to the continuous land subsidence and sea level rise. On May 23rd, 2022, an extreme tidal flood happened and impacted a wide area around the central part of the Northern Coast of Java, with reports indicating that the inundated area was larger than that of typical flood events. Although several researchers have conducted local inundation mapping in various districts, comprehensive flood mapping of this event over a larger area has not yet been undertaken. Such study would benefit for hydraulic flood models. Therefore, this study aimed to map the coastal flood extent around the central part of the Northern Coast of Java using Sentinel-1 imagery data processed through the Google Earth Engine (GEE). The delineated inundation at several points was then compared with field observations from a previous study. The analysis suggests that Sentinel-1 is generally capable of estimating flood extent, although additional measures are necessary for mapping in densely populated urban areas. The findings indicate that the area inundated by the May 2022 flood was at least 5,562 hectares larger compared to the flooding in April 2022.
Carrying capacity approach for agriculture land management in land subsidence area of West Java province
Authors: Giwangkoro Aqila Janitra Sigfreda , Nabila Tiffana Fakhriyati , Asrofi Muhammad Zayyin , Dewantara Erlangga Jati , Putri Ratih Fitria
Published: December 2023

West Java is one of the provinces in Indonesia which has high agricultural productivity. That way, it is necessary to carry out an analysis of the carrying capacity of agricultural land in West Java Province in 2022. The method used to calculate carrying capacity of agricultural land is the combination of Odum, Christeiler, Howard, and Isard theories which is suitable for local conditions and can assess the factors that affect the level of carrying capacity of land in an area. West Java Province has a carrying capacity of agricultural land of 0.74. The value of population pressure in West Java Province with a dominance of less than 1 indicates that districts/cities in West Java Province are dominated by the carrying capacity of high agricultural land. The high rate of population growth and not accompanied by an area of land capable of supporting the needs of the population can be a threat to the availability of sustainable agricultural land.
Impacts of disruptive innovation with the emergence of startups and startup users in the informal sector of Palembang City, Indonesia
Authors: Pitoyo A.J. , Kurniawan A. , Monanisa  , Aryaningrum K. , Sukmaniar  , Saputra W.
Published: December 2023

This study aimed to explain the impacts of disruptive innovation with the emergence of startups and startup users in the informal sector in Palembang City. It employed a mixed-methods design. In the quantitative part, a questionnaire was used as a tool to collect data from 384 respondents, and statistical analyses in the forms of percentage calculation and cross-tabulations were conducted. In the qualitative method, an interview guide was used to gather data from 16 informants, and the data obtained were analyzed using data reduction, data display, conclusion drawing, and verification. The main results of the study are that the characteristics of startups and startup users within the city’s informal-sector worker population are businesses that rely on existing markets, bootstrapping, and are for profit. In addition, disruptive innovation has positive impacts, namely gaining more experience for startups and increasing revenue for startup users, and both startups and startup users experience no negative impact. The main conclusion drawn from these results is that startups and startup users run the same types of business based on the market used, source of funding, and motivation. Also, they feel different positive impacts of disruptive innovation but share the same experience about the negative impact.
Settlement mapping analysis as land use change monitoring in Bogor Regency sub urban area
Authors: Merlina  , Dewantara E.J. , Putri R.F.
Published: December 2023

Settlements are one of the basic human needs that need to be fulfilled. The development of settlements has implications for changes in land use. The high urban population affects the need for settlements in East Cilebut Village as a suburb area which is included in the peri-urban area. East Cilebut Village has the highest population density in Sukaraja District. Physical changes to the area in East Cilebut Village occurred in 2015 and 2020 with the emergence of new settlements. The research was conducted as a form of monitoring the changes in land use into settlements in East Cilebut Village. Monitoring was carried out by mapping settlement blocks in 2015 and 2020. The growth of settlement area was identified through Google Earth satellite imagery in 2015 and 2020. Data processing techniques were carried out by interpreting and on-screen digitizing satellite imagery using ArcGIS. The results of data processing were analyzed descriptively by presenting the data in the form of graphs and maps. Changes in settlement area occurred from 2015 to 2020. The settlement area in 2020 was higher than 2015. The results of data processing are expected to provide advice on settlement development policies for the local government.
Correlation between alterations in degree of urbanization and the dynamics of agricultural land in Karawang regency
Authors: Wijdani Ach. Firyal , Kurniawan Andri , Heru Murti B.S Sigit
Published: December 2023

Karawang is part of the Jakarta-Bandung conurbation and is the largest rice producer there. Due to its strategic position and high agricultural potential, Karawang is interesting to be researched. This research has two aims: (1)to describe the degree of urbanization in Karawang and (2)to know the correlation between changes in the degree of urbanization in Karawang and the dynamics of rice fields. The classification of the degree of urbanization uses the level 2 classification by the European Union using built-up area and population data. Built-up area is extracted from land cover data and classified using Landsat imagery with Support Vector Machine classification. To find out the correlation, panel data regression is used. The results show that Karawang is dominated by the Suburban or Peri-Urban class. However, changes in the degree of urbanization occurred mostly in the central region, many of which became Urban Centers after 2000. The research revealed major transformations in land cover but surprisingly found no significant correlation between changes in the degree of urbanization and changes in agricultural land. These results emphasize the need for comprehensive policies that consider various economic, social, and policy factors related to the region’s sustainable land management and urban planning.
Land Use Changes of Ternate Island 2017-2022
Authors: Kusrini  , Worosuprojo Suratman , Kurniawan Andri , Hizbaron Dyah Rahmawati
Published: December 2023

The phenomenon of land use change always increases with population growth so that sooner or later these conditions will cause changes in land use. This study aims to determine changes in land use on Ternate Island in 2017-2022. The method used maximum likelihood classification and used Ternate island land use data from sentinel 2 image extraction in 2017, 2020 and 2022 to analyze changes in land use. There are 7 forms of land use in the study area, namely water bodies, dense vegetation, bushes, farm land, settlements, bare land, Scrub and cloud cover that cannot be extracted from multispectral images. Land use that dominates the island of Ternate is dense vegetation and settlements. Land use, dense vegetation is evenly distributed on the slopes of Gamalama volcano and settlements are scattered at the foot of the volcano. Land use change on Ternate island in 2017-2020 and 2017-2022 is dominated by dense vegetation to settlements. Changes in dense vegetation to gardens and grasses are land clearing activities in preparation for the use of settlement land.