bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation and Prevention of Intraosseous Temperature Rise in Guided Implant Surgery: An in Vitro Study
Authors: Uçkun Gözde Gökçe , Saygılı Sina , Arınkan Berk , Erdem Mehmet Ali , Çankaya Abdulkadir Burak
Published: October 2023

Background
In this study; the temperature changes in the implant preparation sites using a surgical guide and using the traditional method on sheep iliac crest bones imitating D3 density in in-vitro conditions were compared. In addition, the effects of the temperature of the solution used while cooling with the irrigation solution during the preparation of the implant site and the effects of performing osteotomy at low speed without cooling on the temperature formed in the bone were also evaluated in the study.
Methods
A surgical guide was prepared using stereolithographic technology. Temperature changes were measured using a K-type thermocouple. On 40 sheep iliac bone specimen; using a surgical guide, four implant sites with dimensions of 2.9 mm x 8.5 mm, 2.9 mm x 13 mm, 3.8 mm x 8.5 mm, 3.8 mm x 13 mm were prapared as experimental groups; and a 3.5 mm x 10 mm implant site was prepared as a control group with the traditional method.
Results
A statistically significant rise was observed in the temperature as the bur diameter increased in all groups. Temperature rise in the implant sites prepared using surgical guide at high speed under irrigation was statistically significantly higher than the traditional method. The temperature rise in the group irrigated with solution cooled to 10°C was found to be significantly lower than in the group irrigated with solution at 24°C and in the group in which the implant sites were prepared at low speed without cooling.
Conclusions
The use of a surgical guide causes an increase in intraosseous temperature by preventing the coolant from reaching the surgical area but the intraosseous temperature can be kept within safe limits with external irrigation, which is applied effectively in accordance with the patient-specific conditions.
Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth
Authors: Furukawa Natsuki , Yang Wendy , Chao Alex , Patil Akash , Mirando Adam , Pandey Niranjan , Popel Aleksander
Published: October 2023

Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1 treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 is a unique peptide that functions both as an anti-angiogenic peptide and as an oncolytic peptide and has a therapeutic potential to treat cancer.
Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy
Authors: Chakraborty Tonmoy , DIBAJI HASSAN , SHOTORBAN Ali KAZEMI NASABAN , HABIBI MAHSA , GRATTAN RACHEL , LUCERO SHAYNA , SCHODT DAVID , Lidke Keith A. , PETRUCCELLI JONATHAN , LIDKE DIANE , LIU SHENG
Published: October 2023

The ability to image at high speeds is necessary in biological imaging to capture fast-moving or transient events or to efficiently image large samples. However, due to the lack of rigidity of biological specimens, carrying out fast, high-resolution volumetric imaging without moving and agitating the sample has been a challenging problem. Pupil-matched remote focusing has been promising for high NA imaging systems with their low aberrations and wavelength independence, making it suitable for multicolor imaging. However, owing to the incoherent and unpolarized nature of the fluorescence signal, manipulating this emission light through remote focusing is challenging. Therefore, remote focusing has been primarily limited to the illumination arm, using polarized laser light for facilitating coupling in and out of the remote focusing optics. Here we introduce a novel optical design that can de-scan the axial focus movement in the detection arm of a microscope. Our method splits the fluorescence signal into S and P-polarized light and lets them pass through the remote focusing module separately and combines them with the camera. This allows us to use only one focusing element to perform aberration-free, multi-color, volumetric imaging without (a) compromising the fluorescent signal and (b) needing to perform sample/detection-objective translation. We demonstrate the capabilities of this scheme by acquiring fast dual-color 4D (3D space + time) image stacks, with an axial range of 70 μm and camera limited acquisition speed. Owing to its general nature, we believe this technique will find its application to many other microscopy techniques that currently use an adjustable Z-stage to carry out volumetric imaging such as confocal, 2-photon, and light sheet variants.
Microbial Signatures in COVID-19: Distinguishing Mild and Severe Disease via Gut Microbiota
Authors: Galeeva Julia S. , Fedorov Dmitry E. , Starikova Elizaveta V. , Manolov Alexander I. , Pavlenko Alexander V. , Selezneva Oksana V. , Klimina Ksenia M. , Veselovsky Vladimir A. , Morozov Maxim D. , Yanushevich Oleg O. , Krikheli Natella I. , Levchenko Oleg V. , Andreev Dmitry N. , Sokolov Filipp S. , Fomenko Aleksey K. , Devkota Mikhail K. , Andreev Nikolai G. , Zaborovsky Andrey V. , Bely Petr A. , Tsaregorodtsev Sergei V. , Evdokimov Vladimir V. , Maev Igor V. , Govorun Vadim M. , Ilina Elena N.
Published: October 2023

Background
The global healthcare landscape has changed dramatically as a result of the COVID-19 pandemic caused by SARS-CoV-2. In addition to focusing on treatments and vaccines, it is crucial to investigate the effects of the virus on infected individuals. Recent studies have discovered that SARS-CoV-2 can infect the gut, affecting the gut microbiota and revealing a new aspect of the virus. This study examined the differences in gut microbiota composition between COVID-19 patients with severe and mild conditions.
Methods
In this study, we utilized 16S rRNA metagenomic sequencing to examine the fecal samples obtained from 49 patients with mild and 43 patients with severe cases of COVID-19 upon their admission to the hospital.
Results
Differential abundance analysis with respect to comorbidities on the 313 most abundant ASVs suggested an association of Enterococcus faecium, Rothia mucilaginosa, Akkermansia muciniphila, Schaalia odontolytica, Eubacterium limosum, and Slackia isoflavoniconvertens species with a severe condition, and Faecalibacterium prausnitzii, Ruminococcoides bili, Turicibacter sanguinis, Alistipes putredinis, Bacteroides vulgatus, Bacteroides stercoris, Lachnospiraceae bacterium sunii NSJ-8, Blautia faecis, and Anaerostipes hadrus with a milder course of the disease. Network analysis using SPIEC-EASI revealed keystone taxa and structural differences between the mild and severe groups, suggesting an increased level of bacterial connectivity disruption within the severe group.
Conclusion
Our study highlights the diverse impacts of SARS-CoV-2 on the gut microbiome among both mild and severe COVID-19 patients, showcasing a spectrum of microbial responses to the virus. Importantly, these findings align, to some extent, with observations from other studies on COVID-19 gut microbiomes, despite variations in methodologies.
Caregivers' job stress related to oral health care of the elderly in long-term care facilities during a prolonged COVID-19 pandemic
Authors: Park Ji-A , Han Sol , Paik Hye-Ran , Lee Jae-Young , Jin Bo-Hyoung
Published: October 2023

Background The COVID-19 pandemic has been a great ordeal for elderly individuals and their caregivers. Oral health care for the elderly during the pandemic would be burdensome for those in long-term care facilities. Therefore, we confirmed caregivers’ behavioral practices and stress related to oral health care and infection control for the elderly in long-term care facilities after the COVID-19 outbreak, their relationship with job evaluations, and changes according to the prolonged pandemic. Methods Two surveys were administered to 215 and 201 caregivers working in long-term care facilities in 2020 and 2022, respectively, during the COVID-19 pandemic. The surveys assessed caregivers’ sociodemographic characteristics and job status, infection control behaviors, psychological stress in providing oral health care to the elderly during the COVID-19 pandemic, overall job stress and job satisfaction in elderly care, and turnover intentions. We analyzed the pattern in each year, the changing trend from 2020 to 2022, and the correlations among them for the behavioral and psychological impact on caregivers by the COVID-19 outbreak using an online surveying system. Results After the COVID-19 outbreak, infection control behaviors (personal protection and cross-infection prevention measures) in providing oral health care to the elderly increased rapidly. The most significant stressor for caregivers in this work was the limitation of their daily lives, followed by the challenge of managing the oral health problems of elderly individuals. A low practice rate of infection control behaviors and high levels of stress related to oral health care and elderly care jobs were correlated with low job satisfaction levels and high turnover intention. As the pandemic extended over three years from 2020 to 2022, infection control behavior practice further improved, and all stressors (e.g., fear, burden, and difficulty) in oral health care for the elderly declined. Although overall job stress in older people’s healthcare was similar, job satisfaction decreased, and serious concerns about job turnover increased significantly. Conclusions We identified behavioral and psychological stress and changes in the oral health care of caregivers for older people during the COVID-19 pandemic. Based on these results, we should have a system to support caregivers who care for the elderly to maintain their oral health and quality of life in response to future public health crises.
Novel biomarkers involved in neuroblastoma revealed by integrative analysis of GEO data
Authors: Xiong Zijun , Xu Mingjun , Yuan Ping , Yu Kefei , Xing Huanhuan , Qiu Liangyu , Yang Ruofan , Zhang Pu , Li Qiang , Zhang Jun , Wang Zihan , Zhao Liang , Gu Jiaowei , Liu Wenting
Published: October 2023

In this study, comprehensive bioinformatics analysis was used to identify differentially expressed genes (DEGs) between neuroblastoma cancer tissues and normal tissues, and to screen the hub genes related to neuroblastoma. GSE54720 and GSE78061 datasets were downloaded from the Gene Expression Omnibus (GEO) database to screen DEGs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed on common DEGs. The protein-protein interaction (PPI) network was constructed using STRING database and Cytoscape software, and the top15 hub genes were screened out. Finally, KIF5C, TAGLN3, and SNAP91 were identified by alignment in OMIM, DisGeNET, GeneCards databases, and PubMed. These three genes are neuroblastoma related genes that have never been reported in the literature and experimentally validated. We identified a total of 37 common DEGs from the two microarray databases. KEGG pathway analysis showed that these DEGs were mainly involved in dopaminergic synapses, motor proteins and phenylalanine metabolism related pathways. GO enrichment analysis showed that KIF5C, TAGLN3 and SNAP91 were mainly concentrated in axon guidance, axon genesis, axon development, distal axon, neuronal cell body, and synaptic vesicle transport, suggesting that they may be involved in biological functions such as protein binding, plasma membrane, membrane composition and nucleus. Through OMIM, DisGeNET, GeneCards databases, and PubMed, we found that neuroblastoma related genes KIF5C, TAGLN3, and SNAP91 are associated with the proliferation and migration of other tumors. The identification of hub genes and molecules by bioinformatics methods in this study helps to reveal the potential pathogenic mechanism of neuroblastoma. These genes may be used as diagnostic indicators and therapeutic biomarkers for neuroblastoma, thereby improving the understanding of the molecular mechanism of neuroblastoma.
Association between physiological factors and grip and leg extension strength for predicting health outcomes: Tohoku Medical Megabank Community-based cohort study
Authors: Noji Yoshiaki , Hatanaka Rieko , Nakaya Naoki , Kogure Mana , Nakaya Kumi , Chiba Ippei , Kanno Ikumi , Nakamura Tomohiro , Tsuchiya Naho , Momma Haruki , Hamanaka Yohei , Orui Masatsugu , Kobayashi Tomoko , Uruno Akira , Kodama Eiichi N , Nagatomi Ryoichi , Fuse Nobuo , Kuriyama Shinichi , Hozawa Atsushi
Published: October 2023

Background
Upper and lower extremity muscle strengths predict health outcomes. However, the difference between each muscle's strength in physiological factors affecting the causal association is unclear. We aimed to evaluate the association between physiological data and muscle strength, measured using the grip and leg extension strengths, among Japanese adults.
Methods
We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years, who lived in Miyagi Prefecture, Japan. The grip strength was measured using a dynamometer. The leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data were assessed, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors.
Results
Both grip and leg extension strengths were positively associated with the bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second and eGFR, and negatively associated with the waist circumference and percentage body fat mass in both sexes. The diastolic blood pressure was positively associated with grip strength in both sexes and leg extension strength in men but not with leg extension strength in women. HDL cholesterol and red blood cell counts were positively associated with grip strength and leg extension strength in women, but not in men. In both sexes, the pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with the grip and leg extension strengths, respectively.
Conclusions
The grip strength and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and eGFR, but the associations with the other factors were not always consistent. The impact of muscle strength on physiological data may partially follow different paths for the grip and leg extension strengths.
Trial Registration
Not applicable
Development of a rapid and comprehensive genomic profiling test supporting diagnosis and research for brain tumors
Authors: Nakashima Takuma , Yamamoto Ryo , Ohno Makoto , Sugino Hirokazu , Takahashi Masamichi , Funakoshi Yusuke , Nambu Shohei , Uneda Atsuhito , Yanagisawa Shunsuke , Uzuka Takeo , Arakawa Yoshiki , Hanaya Ryosuke , Ishida Joji , Yoshimoto Koji , Saito Ryuta , Narita Yoshitaka , Suzuki Hiromichi
Published: October 2023

A prompt and reliable molecular diagnosis for brain tumors has become crucial in precision medicine. While Comprehensive Genomic Profiling (CGP) has become feasible, there remains room for enhancement in brain tumor diagnosis due to the partial lack of essential genes and limitations in broad copy number analysis. Additionally, the long turnaround time of commercially available CGPs poses an additional obstacle to the timely implementation of results in clinics. To address these challenges, we developed a CGP encompassing 113 genes, genome-wide copy number changes, and MGMTpromoter methylation. Our CGP incorporates not only diagnostic genes but also supplementary genes valuable for research. Our CGP enables us to simultaneous identification of mutations, gene fusions, focal and broad copy number alterations, and MGMT promoter methylation status, with results delivered within a minimum of four days. Validation of our CGP, through comparisons with whole-genome sequencing, RNA sequencing, and pyrosequencing, has certified its accuracy and reliability. We applied our CGP for 23 consecutive cases of intracranial mass lesions, which demonstrated its efficacy in aiding diagnosis and prognostication. Our CGP offers a comprehensive and rapid molecular profiling for brain tumors, which could contribute to clinical practices and research in the field of brain tumors.
Downregulated the expression of DNMT3B by suppressing PI3K/Akt signaling pathway and enhances the chemosensitivity of glioblastoma to temozolomide.
Authors: Kan Wenwu , Gao Linhui , Chen Jingnan , Chen Li , Zhang Guojun , Hao Bilie , He Min , Chen Xudong , wang cheng
Published: October 2023

Purpose
Glioblastoma is the most common malignant brain tumors and has the poorest prognosis. And a poor prognosis is attributed to chemoresistance to temozolomide (TMZ), the first-line drug for treating glioblastoma. This study aimed to investigate how to enhance the chemosensitivity of glioblastoma to temozolomide.
Methods
Human glioblastoma cell line U251 was used to established temozolomide-resistant U251 (U251-TMZ) cell line by stepwise induction of temozolomide-resistant strains. Reverse Transcription-quantitative PCR(RT-PCR) was applied to detect chemoresistance-related gene expression. Following DNMT3B-siRNA lentiviral vectors transfection and suppressing PI3K/Akt signaling pathway, western Blotting (WB) and RT-PCR were applied to detect DNMT3B gene, p-Akt, t-Akt, p-PI3K, t-PI3K protein expression and cell apoptosis was detect flow cytometry analyses.
Results
Whole-transcriptome analysis revealed that the level of DNMT3B gene expression was significantly up-regulated in U251-TMZ cell line compared to U251 cell line. Moreover, we found that DNMT3B down-expression is correlated with increasing the chemosensitivity of glioblastoma cells to TMZ. Meanwhile, we also found that p-Akt and p-PI3K protein expression in U251-TMZ cells were significant elevated compared with U251 cells. Subsequently, the PI3K/Akt signaling pathway was suppressed using LY294002, leading to a notable inhibition of PI3K phosphorylation and a significant decrease in DNMT3B expression in U251-TMZ cells.
Conclusion
DNMT3B down-expression can inhibit the proliferation of glioblastoma cells and induce the glioblastoma cells apoptosis in vitro. Additionally, the PI3K/Akt signaling pathway plays an important role in the chemosensitivity of glioblastoma cells to temozolomide by regulating the DNMT3B expression.
Determination of heavy metals Cd (II) and Pb (II) with an electrochemically treated pencil graphite electrode in carbonated mineral water using anodic stripping voltammetry
Authors: Afacan Reyhan Selin Uysal
Published: October 2023

The starting point of this study was to propose a simple and rapid electrochemical approach for quantitative analysis of heavy metal ions in natural mineral water samples. For this purpose, it was aimed to quantitatively determine Cd (II) and Pb (II) ions in gaseous mineral waters by square wave anodic stripping voltammetry (SWASV) by modification of pencil graphite electrode (PGE) with graphene oxide (GO) and deposition of auric acid solution. A three-step modification process was implemented to the PGE surface, including graphene oxide coating (GO/PGE), GO reduction (ERGO/PGE), and gold coating (Au-ERGO/PGE). The morphologies and electrochemical properties of the developed electrode were checked with scanning electron microscopy (SEM), cyclic voltammetry (CV), and SWASV. The results show the synergistic effect of graphene oxide and auric acid-activated surface and good electrical conductivity leading to the deposition of Cd (II) and Pb (II) on the electrode surface. Under optimum conditions, a linear behavior was obtained between currents and Cd (II) and Pb (II) concentrations in the range of 0.6–1.6 µM and 0.4–1.6 µM. Detection limits were calculated as 0.36 µM and 0.24 µM for Cd (II) and Pb (II), respectively. Finally, the improved electrode was applied for the detection of Cd (II) and Pb (II) in gaseous natural mineral water samples with high recovery rates. This study revealed that Au-ERGO/PGE modification could be an alternative route in practical applications of electrochemical detection of heavy metal ions.
WITHDRAWN: Seismic Imaging of the Kumaon-Garhwal Himalaya: Insights into the Main Himalayan Thrust and the Crust-Mantle Boundary
Authors: Mandal Prantik , Raghavan R. V. , Saha Satish , Biswas Rahul , Prathigadapa Raju
Published: October 2023

The seismic velocity tomography of reveals a high-velocity (5–20% increase in dVp, 4–16% increase in dVs, low Vp/Vs (~ 1.5–1.8)) upper crust between 0 and 20 km depth and a low-velocity (10–20% drop in dVp, 4–12% drop in dVs, high Vp/Vs (~ 1.65-2.0)) lower crust between 20 and 40 km depth. Our modelling detects a low-angle north-dipping low-velocity layer (10–20% drop in Vp and Vs, 10–15% increase in Vp/Vs) at depths of 8–20 km, which may be the Main Himalayan Thrust (MHT). The presence of low-velocity pockets in the lower crust may be indicative of partial melts, while those in the upper and middle crust may be indicative of aqueous or metamorphic fluids. The Common Conversion Point stacking (CCP) of radial P- Receiver Functions (PRFs) detects a double Moho structure below the rupture zone of the 1803 Mw7.8 Garhwal, the 1991 Mw6.8 Uttarkashi, and the 1999 Mw6.5 Chamoli earthquakes, which might be accumulating marked crustal stresses on the MHT. Our modelling also suggests that fluids or high pore-fluid pressure caused the above-mentioned three Mw≥6.5 earthquakes, which occurred in low-velocity zones on the MHT. Our CCP imaging also suggests a north-dipping crust-mantle boundary (with larger positive impedance contrast) at depths of 30–55 km while these CCP images also detect a north-dipping zone with larger negative impedance contrast at depths of 8–20 km, possibly representing the low-velocity MHT. Our joint inversion of radial PRFs and group velocity dispersion data of Rayleigh waves has also mapped an MHT and Moho that dip to the north.
Research on Injury Protection for Rear Pregnant Occupants in Frontal Impact
Authors: Wang Ping , Tang Youming , Zhang Yi , Mao Anli
Published: October 2023

This paper investigates the protective effects of restraint systems, specifically the three-point and combined safety belts, on pregnant occupants during transportation safety. The goal is to explore potential injury risks and enhance safety measures. Firstly, a restraint system model of the rear female occupant in the frontal full-width collision is established and validated. Secondly, the finite element model of the uterus at 30 weeks of pregnancy is established and coupled with Hybrid III 5th female facet human model to build a pregnant occupant model. Finally, according to the injury mechanism of the pregnant occupant and fetus, a comprehensive injury index WICp is proposed to assess the injury of the pregnant occupant and fetus. Research has been conducted on the effectiveness of wearing both a combined safety belt and a three-point safety belt by the pregnant occupant under various impact loads to ensure optimal protection. The results reveal that compared with the three-point safety belt, the combined safety belt worn by the pregnant occupant could reduce the abdominal compression value by 38% on average, decrease the Uterus Placental Interface (UPI) strain at the uteroplacental intersection by an average of 18.3%, and make the average reduction of the comprehensive injury by 13.4%. When the impact speed is less than 55km/h, the UPI strain value of the uteroplacental interface will not exceed the limit value of 60%. As a result, the risk of placental abruption for the pregnant occupant is reduced, and the protective effect during transportation safety for the pregnant and fetus is enhanced. The research results provide a scientific theoretical basis and reference value for pregnant occupants and fetuses to develop safer, more reliable, and more comfortable seat belts.
A Repertoire of Ethanol-Producing Human Microbes
Authors: MBAYE Babacar , WASFY Reham MAGDY , ALOU Maryam TIDJANI , BORENTAIN Patrick , GEROLAMI Rene , DUFOUR Jeans Charles , MILLION Matthieu
Published: October 2023

Background Studies of the relationship between the human microbiota and the host, particularly in the maintenance of health and the onset of disease, is still a topical issue. The microbiota is home to a number of microorganisms, including bacteria, yeasts, viruses and archaea, which play a crucial role in the body's proper functioning. In the presence of risk factors, mainly antibiotics, unbalanced diet and so on, a microbiota disequilibrium known as dysbiosis can set in, eventually leading to the onset of several diseases. Several mechanisms have been described for this dysbiosis, but the one linked to endogenous ethanol production is under-investigated. Results The aim of this review is to provide an inventory of all ethanol-producing microorganisms in humans. Over 36,0000,000 articles were searched on pubmed with our query, of which 7275 were retained. Of these, 5397 contributed to the review, enabling us to identify 85 ethanol-producing microorganisms in humans, including 61 bacterial species and 24 yeasts. Conclusion Our results establish an important role for endogenous ethanol in the onset of certain diseases. They will also enable us to better understand the origins of diseases linked to this mechanism, and to improve diagnosis and therapeutic management in the future.
Analysing the psychometric properties of the PHQ-9 using item response theory in a Chinese adolescent population
Authors: Gao Xuliang , Liu Ziyu
Published: October 2023

Background
People are more likely to fall victim to depression during adolescence since it is a period of rapid bio-psycho-social transformation. Despite this, most depression research has concentrated on clinical issues, and evaluating depressive symptoms in teenagers is not as widespread. This study used item response theory (IRT) to examine the psychometric properties of the Patient Health Report scale (PHQ-9) in Chinese adolescents. Meanwhile, item function difference tests were revealed to check whether there were differences in depression symptoms in this group based on education and gender.
Methods
In this research, the PHQ-9 was employed as a measurement tool, and 5958 valid data were obtained from 12 secondary schools in China (Mage= 13.484; SDage= 1.627; range 11–19 years; 52.17% boys).
Results
IRT examines that all items of PHQ-9 satisfy monotonicity, unidimensionality, local independence, and good psychometric properties. Furthermore, DIF analysis revealed gender and educational disparities in adolescent depressive symptoms.
Conclusion
The study indicates that the PHQ-9 possesses favorable psychometric properties in Chinese adolescents. As a result, it serves as a valuable tool for effectively screening depressive symptoms in adolescents. It provides a foundation for prioritizing the development of secondary school students' physical and mental health.
Short-Term Safety Evaluation of Albumin-Bound Paclitaxel in Intraoperative and Postoperative Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer
Authors: Zhou Jingxiang , Cai Xiaopeng , Lu Zhao , Xiong Bin , Peng Chunwei
Published: October 2023

Purpose
To evaluate the short-term safety of albumin-bound paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) during and after gastric cancer (GC) surgery.
Methods
A retrospective analysis of clinical data was conducted for GC surgery patients at Zhongnan Hospital of Wuhan University, from January 2020 to September 2022. The study group (n = 120) received HIPEC and the control group (n = 268) did not receive albumin-bound paclitaxel. Short-term safety indicators including intraoperative complications, hematological toxicity, liver and kidney function, and gastrointestinal function recovery, were compared between the two groups.
Results
There were no statistically significant differences between the two groups regarding intraoperative complications, hematological toxicity, liver and kidney function, and gastrointestinal function recovery time (P > 0.05 for all). In the study group, patients were further divided into subgroups based on dose and timing. Subgroup analysis revealed no significant differences among the different dose subgroups. However, when focusing on timing subgroups, postoperative subgroup exhibited significantly higher white blood cell counts and bilirubin levels compared to intraoperative subgroup, while the intraoperative subgroup had significantly higher bilirubin levels compared to both postoperative and intraoperative plus postoperative subgroups.
Conclusion
Albumin-bound paclitaxel demonstrates good safety and tolerability in HIPEC during and after GC surgery, without increasing the risk of intraoperative complications.
The effect of remote programming on deep brain stimulation in Parkinson’s disease: a retrospective study
Authors: Li Dianyou , Wan Xiaonan , Duan Chengcheng , Lin Zhengyu , Zeng Zhitong , Zhang Chencheng
Published: October 2023

For Parkinson’s disease (PD) patients undergoing deep brain stimulation (DBS), remote programming (RP) was developed to eliminate the burden of repeat office visits for standard programming (SP) sessions to maximize the treatment effect. No studies comparing the treatment effects of RP with SP directly were performed. Thirty-two propensity score matched patients were retrospectively recruited and allocated to the RP or SP group according to their programming methods, and clinical outcomes were compared at ~12-month follow-ups between the two groups. No differences were found in changes of the Unified PD Rating Scale III score, PD Questionnaire-8 score, or levodopa equivalent daily dose between the groups (p>0.05); and the average cost of the RP group decreased compared with their SP sessions (p<0.001), and was less than the average cost of the SP group (p=0.040), even though the patients in the RP group reside further from our center than patients in the SP group (p=0.004). This study demonstrated RP alleviates the cost burden of the short-term follow-ups for PD patients without compromising the DBS treatment effect.
Evaluation of Optical Coherence Tomography Angiography Findings of Fibromyalgia
Authors: Gezginaslan Tuğba Aydoğan , Limon Utku , Kaleoğlu Özlem , Saygın Işılay Özsoy , Bozkurt Erdinç , Akçay Betül İlkay Sezgin
Published: October 2023

Purpose: To execute comprehensive study about optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) findings in fibromyalgia (FM) to elaborate macula, optic disk changes.
Methods: A total of 84 participants comprising 44 FM patients and 40 healthy controls were included. Macular full thickness, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) +, GCL++, superficial vessel density (SVD), deep vessel density (DVD), foveal avascular zone (FAZ), circumpapillary vessel density (cpVD), RNFL measurements were evaluated using OCT/OCTA. Each FM patient completed Fibromyalgia Impact Questionnaire (FIQ), Short Form-36 (SF-36), Widespread Pain Index (WPI), Symptom Severity Scale (SSS). OCT/OCTA parameters were compared between controls and FM patients. Correlation between FIQ, SF-36, WPI, SSS and OCT/OCTA were evaluated. Logistic regression analysis were performed to analyze associated parameters.
Results: Macular full thickness parafoveal nasal, temporal, superior, inferior, perifoveal temporal, superior, GCL+ parafoveal nasal, temporal, superior, inferior, GCL+ perifoveal temporal, GCL++ parafoveal nasal, temporal, superior, inferior, GCL++ perifoveal nasal were lower in FM patients. Difference was not found in SVD, DVD or FAZ measurements. cpVD in nasal, superior, inferior were higher in FM patients. RNFL temporal was lower in FM patients. Weak correlations were observed between FIQ, SF-36, WPI, SSS scores and OCT/OCTA parameters. Superior cpVD was associated with FM due to logistic regression analysis.
Conclusions: OCT/OCTA can provide objective supplementary measurements in the assessment of FM. Changes in measurements like RNFL, macula GCL, cpVD may be evaluated as a diagnostic criteria or used to understand the peripheral effects of FM.
A non-invasive glucose sensor based on 3D graphene oxide-MXene composite electrode for the detection of saliva glucose
Authors: Shang Ling-Jun , Yu Shuai-Qun , Shang Xin-Wei , Wei Xiang-Yu , Wang Hui-Ying , Jiang Wen-Shuai , Ren Qiong-Qiong
Published: October 2023

Regular monitoring of blood glucose levels is crucial in diabetes management. Commonly used procedures may be invasive and can lead to cross-infection and inflammation. Therefore, a safe, non-invasive blood glucose-monitoring technology is needed. Herein, a 3D reduced graphene oxide (rGO) electrode was modified with MXene (Ti3C2) and gold nanoparticles (AuNPs) to construct a non-invasive, saliva glucose detection electrode. The Au/rGO-Ti3C2 electrode exhibited good detection performance for glucose concentrations in the range of 10 µM–21 mM at a working potential of 0.6 V, with a detection limit of 3.1 µM glucose, and a sensitivity of 355 µA mM− 1 cm− 2. The Au/rGO-Ti3C2 electrode showed almost no response to the addition of interfering substances, and no effect was observed upon subsequent glucose detection. The sensor could detect glucose in artificial saliva and saliva supernatant. The modified electrode showed a significant response to low glucose concentrations, even at 10 µM. These results indicate the suitability of the Au/rGO-Ti3C2 electrode for saliva glucose detection. The electrode developed in this study has great potential in improving the efficiency of diabetes monitoring through pain-free, non-invasive glucose detection in saliva.
A systematic Adaptive Mesh Refinement method for Large Eddy Simulation of turbulent flame propagation
Authors: Vanbersel Benjamin , Ramirez Francis Adrian Meziat , Mohanamuraly Pavanakumar , Staffelbach Gabriel , Jaravel Thomas , Douasbin Quentin , Dounia Omar , Vermorel Olivier
Published: October 2023

This paper presents a feature-based Adaptive Mesh Refinement (AMR) method for Large Eddy Simulation of propagating deflagrations, using massive-scale parallel unstructured AMR libraries. The proposed method, named Turbulent Flame Propagation-AMR (TFP-AMR), is able to track the transient dynamics of both the turbulent flame and the vortical structures in the flow. To handle the interaction of the turbulent flame brush with the vortical structures of the flow, a vortex selection criterion is derived from flame/vortex interaction theory. The method is built with the general intent to prioritise conservatively estimated parameters, rather than to rely on user-dependent parameters. In particular, a specific mesh adaptation triggering strategy is constructed, adapted to the strongly transient physics found in deflagrations, to guarantee that the quantities of interest consistently reside within a region of high accuracy throughout the transient process. The methodology is applied and validated on several elementary cases representing fundamental bricks of the full problem: (1) a laminar flame propagation, (2) the advection of a pair of non-reacting vortices, (3) a flame/vortex interaction. The method is then applied to three different configurations of a three-dimensional complex explosion scenario in an obstructed chamber. All cases demonstrate the TFP-AMR capability to recover accurate results at reduced computational cost without requiring any ad hoc tuning of the AMR method or its parameters, thus demonstrating its genericity and robustness.
Decreasing Photoreactivity and Concurrent Change in Dissolved Organic Matter Composition with Increasing Inland Water Residence Time
Authors: Grasset Charlotte , Einarsdóttir Karólína , Catalán Núria , Tranvik Lars J. , Groeneveld Marloes , Hawkes Jeffrey , Attermeyer Katrin
Published: October 2023

Photochemical degradation of dissolved organic matter (DOM) has been the subject of numerous studies, however, its regulation along the inland water continuum is still unclear. We aimed to unravel the DOM photoreactivity and concurrent DOM compositional changes across 30 boreal aquatic ecosystems including peat waters, streams, rivers, and lakes distributed along a water retention time (WRT) gradient. Samples were subject to a standardized exposure of simulated sunlight. We measured the apparent quantum yield (AQY), which corresponds to DOM photomineralization per photon absorbed, and the compositional change in DOM at bulk and individual compound levels in the original samples and after irradiation. AQY increased with the abundance of terrestrially-derived DOM and decreased at higher WRT. Additionally, the photochemical change in both DOM optical properties and molecular composition resembled changes along the natural boreal WRT gradient at low WRT (< 3 yr). Accordingly, mass spectrometry revealed that the abundance of photolabile and photoproduced molecules decreased with WRT along the boreal aquatic continuum. Our study highlights the tight link between DOM composition and DOM photodegradation. We suggest that photodegradation is an important driver of DOM composition change in waters with low WRT, where DOM is highly photoreactive.
Konstruktionswortbildung: Forschungsstand und Perspektiven
Authors: Hein Katrin , Michel Sascha
Published: October 2023

The special issue opens up a construction-grammatical perspective on (German) word formation phenomena and goes back to a DFG-funded conference of the same name, which we held at the University of Düsseldorf in December 2020. The aim is to bundle up for the first time research from the field of German linguistics that is oriented towards construction grammar, and thus to lay the foundation for a 'Construction Word Formation' (cf. Booij 2010) also in the German-speaking world. Furthermore, ‘Construction Word Formation’ as a discipline shall hereby be sharpened. In this context, construction grammar should not be seen as a radical alternative to traditional word formation approaches that completely reinvents the wheel, but rather as a further development that builds on traditional concepts such as the pattern term with prominent consideration of usage-based aspects.
Review: Jackendoff, Ray & Jenny Audring. 2020. The Texture of the Lexicon: Relational Morphology and the Parallel Architecture. Oxford: Oxford University Press. xiii + 312 pages
Authors: Battefeld Malte
Published: October 2023

The Texture of the Lexicon is an ambitious work that doesn’t fail to impress. While its main purpose is to update and refine the original PA framework, it may alternatively serve as a highly accessible introduction to this line of thinking for those unfamiliar with Jackendoff’s previous work. In either case, it can be warmly recommended to anyone sympathetic to cognitive, usage-based approaches to language, or broadly interested in linguistic theory.
Pod ochranou svatého Josefa. Příběh tesařského řemesla v českých zemích.
Authors: Koudelová Jana , Stejskal David , Tippner Jan , Kloiber Michal , Bláha Jiří , Růžička Petr , Kolář Tomáš , Rybníček Michal , Buzek Jaroslav , Dostál Tomáš , Milch Jaromír , Baar Jan , Hess Dominik , Zlámal Jan , Vavrčík Hanuš , Bryol Radek
Published: October 2023

The title of the publication, Under the Protection of St. Joseph. The story of carpentry in the Czech lands, expresses the effort of the team of authors to present the history and tradition of the carpenter's craft to both the professional and general public through articles on the topic and accompanying pictures. The book is structured as a critical catalogue of an exhibition of the same name, located in the historical building of the manorial granary on the premises of the so-called Wooden Town of the Wallachian Open Air Museum, which is part of the National Open Air Museum of the Czech Republic with its registered office in Rožnov pod Radhoštěm. In addition to the texts accompanying the exhibition, the presented images and objects representing carpentry – borrowed from the collections of heritage institutions as well as family heritage – a significant part of the publication consists of expert texts.
Transformational leadership and organizational citizenship behavior: Mediating role of affective commitment and work engagement of hotel employees in Indonesia
Authors: Jufrizen  , Farisi Salman , Muslih  , Sari Maya
Published: October 2023

Employees who voluntarily conduct work that surpasses the criteria allocated to them to help the company achieve its goals exhibit organizational citizenship behavior. This study aims to examine the mediation role of affective commitment and work engagement on the influence of transformational leadership on organizational citizenship behavior. This study used survey methodology. Two hundred frontline staff working over a year in several star-rated hotels in Medan, Indonesia, are used as samples. Data were collected using a Likert scale questionnaire and analyzed using structural equation modeling-part least squares with SmartPLS 4.0 software. The findings show that transformational leadership, affective commitment, and work engagement affect organizational citizenship behavior (p < 0.05). Next, transformational leadership affects affective commitment (p < 0.05) and work engagement (p < 0.05), and transformational leadership affects organizational citizenship behavior through affective commitment (p < 0.05) and work engagement (p < 0.05). The findings of this study recommend that hotel management should use a transformational leadership style when filling managerial positions. In addition, the study results have implications for businesses in terms of creating arrangements that encourage employee engagement and affective commitment, enabling workers to volunteer their time, energy, and ideas to serve their co-workers and the company. This paper helps to develop human resources to maintain the sustainability of hotel industry in Medan, Indonesia. AcknowledgmentThis study is supported by all levels of management at Universitas Muhammadiyah Sumatera Utara for funding Fundamental research in 2022 and thanks also to the ranks of the Institute of Research and Community Service (LPPM) Universitas Muhammadiyah Sumatera Utara.
Exploring the Alignment of Professional Development and Classroom Practices in African Contexts: A Discursive Investigation
Authors: Ajani Oluwatoyin Ayodele
Published: October 2023

Professional development plays a pivotal role in ensuring high-quality education. Well-designed activities empower teachers and improve instructional delivery. Therefore, this study examines the alignment of teacher professional development with classroom practices to meet learner needs. The study conducted a systematic literature review using the PRISM approach, focusing on research from 2003 to 2023 in EBSCO, Google Scholar, and other repositories. Only open-sourced and peer-reviewed English literature was considered. The findings emphasize that teacher professional development aims to equip educators with contemporary knowledge, skills, values, and attitudes that enhance teaching and learning excellence. When structured effectively, these activities boost pedagogical prowess and improve academic outcomes. The study highlights the significance of tailored, learner-centered pedagogical approaches and ongoing professional development opportunities to enhance academic performance. To facilitate effective teacher professional development, the study introduces the Learner-Centered Teacher Professional Development Model (LCTPD). It recommends integrating quality-driven, suitable professional development activities to enhance teaching practices and advance learners' performance.
Using Resilience to Analyze Changes in an Industrial Community in China
Authors: Hu Ying , Garcia Emilio , Oswald Ferdinand , Ji Yichuan
Published: October 2023

Besides its systematic identification with disasters and hazards, resilience could be a powerful tool for understanding changes in the built environment. This study analyses the development of the workers’ residential area in one industrial community (IC) in China after its economic transformation. How can a resilience approach help analyse the impact of economic changes in the built environment?
The ICs first emerged in socialist China in the 1950s and were used to organise social production (factory) and collective life (workers’ residential areas). Although existing research has explored the possible changes in the built environment of ICs before and after economic transformation, these changes that have either taken place or are still taking place have never been quantified. Furthermore, as the most unique and distinctive feature of the built environment, the impact of changes in the level of enclosure of workers’ residential areas after factory bankruptcy has rarely been explored. This study, therefore, uses a resilience approach to analyse the impact of changes in the level of enclosure on the built environment after the factory bankruptcy by taking the case of Shanxi Knitting Factory (SKF) in Taiyuan, China.
This study seeks to use resilience to understand changes in ICs under the background of China’s economic transformation. The finding shows that the factory bankruptcy significantly impacts the changes in the built environment of its workers’ residential area as well as impacts the level of enclosure in the built environment. With the disappearance of enclosures after the factory bankruptcy, the workers' residential area is gradually shifting from an enclosed, isolated, centralised and self-contained industrial auxiliary facility to an open, diversified and heterogeneous space and gradually integrating into the surrounding neighbourhoods of the city.
Proposal for a Binder Blended with PTFE and Japanese Sumi Ink for the Cathode in Microbial Fuel Cells
Authors: Hirose Soichiro , Nishio Yugo , Nakamoto Trang , Taguchi Kozo
Published: October 2023

Various issues, such as population growth, agriculture, and urban expansion, have led to the continuous degradation of water resources. To solve this problem, sustainable water treatment technologies are required. In water treatment, microbial fuel cells (MFCs) have attracted attention because of their low cost and low risk of cross-contamination. However, the performance of the MFC degrades because of microbial adhesion to the cathode. In this research, we proposed using a blend of polytetrafluoroethylene (PTFE) and Japanese Sumi ink to prevent the adhesion of microbial cells to the cathode. The hydrophobic properties of PTFE prevented the adhesion of microbes on the cathode surface. In addition, the Sumi ink improved the electrical conductivity and physical stability of the cathode. It was confirmed that the hydrophobic properties of PTFE and the conductive and physical stability of Sumi ink could be fully exploited by adjusting the composition ratio of PTFE and Sumi ink.