bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypogonadism in Prader–Willi syndrome from birth to adulthood: a 28-year experience in a single centre
Authors: Kherra Sakina , Forsyth Paterson Wendy , Cizmecioglu Filiz Mine , Jones Jeremy Huw , Kourime Mariam , Elsedfy Heba Hassan , Tawfik Sameh , Kyriakou Andreas , Shaikh Mohamad Guftar , Donaldson Malcolm David Cairns
Published: August 2021

Background

Hypogonadism is a key feature of Prader–Willi syndrome (PWS) but clear strategies for hormone replacement are lacking.

Objective

To evaluate the gonadal status and outcome in patients attending a Scottish PWS clinic from 1991 to 2019.

Methods

In 93 (35F:56M) patients, median follow-up 11.2 years, gonadal and pubertal status were assessed clinically. Pelvic ultrasound findings and basal/stimulated gonadotrophins were compared with age-matched controls.

Results

Females:of 22 patients aged > 11, 9 had reached B4–5, while 5 were still at B2–3, and 6 remained prepubertal. Eight patients experienced menarche aged 9.8–21.4 years, none with a normal cycle. Uterine length and ovarian volumes were normal but uterine configuration remained immature, with low follicular counts. Gonadotrophins were unremarkable, serum oestradiol 129 (70–520) pmol/L. Only 5 patients received oestrogen replacement. Males:fifty-four (96%) patients were cryptorchid (9 unilateral). Weekly hCG injections resulted in unilateral/bilateral descent in 2/1 of 25 patients. Of 37 boys aged > 11, 14 (9 with failed/untreated bilateral cryptorchidism) failed to progress beyond G1, 15 arrested at G2–3 (testes 3–10 mL), and 8 reached G4–5. Gonadotrophins were unremarkable except in boys at G2–5 in whom FSH was elevated: 12.3/27.3 vs 3.25/6.26 U/L in controls (P < 0.001). In males aged > 13, testosterone was 3.1 (0.5–8.4) nmol/L. Androgen therapy, given from 13.5 to 29.2 years, was stopped in 4/24 patients owing to behavioural problems.

Conclusion

Despite invariable hypogonadism, few females and only half the males with PWS in this study received hormone replacement. Double-blind placebo-controlled crossover trials of sex steroids are required to address unproven behavioural concerns.
La educación universitaria y el proceso de reincorporación, una visibilización necesaria para trascender el enfoque de la armadura vacía
Authors: Rincón Castellanos Ximena del Pilar , Pinilla León Jenniffer
Published: August 2021

Colombia ha asumido desde hace varios años procesos de reintegración y reincorporación de personas vinculadas a grupos al margen de la ley, orientados a consolidar una paz estable y duradera. Los esfuerzos institucionales, colectivos e individuales han buscado brindar herramientas para asumir las diversas dimensiones en las que se ejerce la ciudadanía en un escenario de posconflicto. La educación es una de estas dimensiones, concebida como aquella de la que depende el éxito de muchos de los esfuerzos del proceso. Pese a que se han diseñado importantes propuestas para los excombatientes, que van desde ciclos de educación básica y media hasta formación para el empleo, se ha privilegiado la oferta técnica y tecnológica, que, si bien se concibe como educación superior, no se ha articulado ni complementado con la oferta universitaria, que a su vez se encuentra sujeta a lineamientos de calidad que implican retos que continúan pendientes de resolver.
Recurso de apelación en el proceso verbal inmediato. Autoridad competente para resolverlo: riesgo de impedimento o recusación
Authors: Moreno Ramírez Marco Antonio , Moreno González Fernando Antonio , Arévalo Sanabria Lina Stefanía
Published: August 2021

Este artículo analiza un error, abiertamente ilegal, en el que incurren autoridades de policía, académicos, eruditos y litigantes, al aceptar, tácita o expresamente, que los inspectores de policía y corregidores son competentes para resolver el recurso de apelación contra las medidas correctivas impuestas por miembros uniformados de la Policía Nacional, designados como comandantes de estación, subestación o Centros de Atención Inmediata. El análisis evidencia que esta competencia no es del inspector de policía ni del corregidor, de conformidad con los preceptos constitucionales, la jurisprudencia de la Corte Constitucional y del Consejo de Estado y la Ley 1801 de 2016. Además, se muestra que si el recurso de apelación contra decisiones de policía tomadas por los anteriores comandantes es resuelto por el inspector o corregidor, estos podrían ser objeto de investigación penal y disciplinaria, o podría derivar en la declaración de nulidad del acto por parte de la Jurisdicción de lo Contencioso Administrativo.
Formación de personal investigador en educación a distancia en México desde una perspectiva interdisciplinaria e histórica
Authors: Ramírez-Díaz José Antonio
Published: August 2021

El presente artículo se redactó con resultados obtenidos de la investigación: El CONACYT como organismo rector de las capacidades de Estado en la relación de la ciencia con el sector educativo (Ramírez Díaz, 2020a) que analiza el impacto de la instrumentación de la política científica en la conformación del campo disciplinar educativo en México. El tema revisado en este trabajo relaciona el desarrollo de las disciplinas vinculadas a la educación con los eventos de institucionalización de la educación a distancia. Su objetivo es profundizar en la complejidad del proceso formativo de especialistas de educación a distancia para optimizarlo. El método de investigación se basó en la historiografía y entrevistas a estudiantado egresado de posgrados en educación, los resultados permitieron esbozar límites teóricos a la formación de comunidades académicas especializadas, en las cuales existe un puente entre las demandas sociales y económicas a nivel macro con los procesos regulatorios y la cultura académica de los grupos de formación. Para establecer la relación se hizo uso de la teoría sobre los “social framework”. Se reconoció, como limitante, la imposibilidad de situar resultados en forma empírica y dentro de un contexto específico que permitiera caracterizar la manera en la cual operan los “social framework” en los grupos académicos. El trabajo arrojó información teórica para realizar investigación empírica sobre la formación especializada y estableció los campos genéricos de la constitución de comunidades de investigación especializada.
Heterogeneidad en el involucramiento en acoso escolar: Un análisis de clases latentes
Authors: Mellado Carlos , Mendez-Bustos Pablo
Published: August 2021

El presente estudio tuvo como objetivo desarrollar una tipología de acoso escolar a través de una técnica estadística que minimiza el error de clasificación en los grupos. Esta tipología permite examinar cómo múltiples atributos del acoso escolar coexisten en las personas, sin separarlos artificialmente. Utilizando un análisis de clases latentes se modelaron seis ítems que representaban los roles de testigo, víctima y sujeto agresor en situaciones de acoso en 440 escolares de Chile, cuya edad fluctuó entre 14 y 20 años (M = 16,30 y DE = 1,42). Se reportan dos modelos con cuatro y cinco clases respectivamente. En el primer modelo se observa un grupo denominado como “No involucrado” (14,5%) el cual no ha participado en situaciones de acoso; un grupo denominado como “Testigo” (56,2%) el cual solamente se ha involucrado como testigo en dichas situaciones; un grupo denominado como “Testigo y víctima” (13,3%) el cual se ha implicado como testigo y víctima en situaciones de acoso y, finalmente, un grupo denominado como “Testigo, víctima y agresor” (16%) el cual se ha implicado en todos los roles. En el modelo de cinco clases se observan los mismos grupos, más uno denominado como “Testigo y agresor” que se ha implicado como testigo y agresor en acoso escolar. Los resultados indican que la mayoría del estudiantado se ha involucrado en situaciones de acoso y que una parte importante se ha involucrado en más de un rol, lo que implica que la victimización y la perpetración del acoso no son mutuamente exclusivos.
El saber de la experiencia del profesorado en la formación inicial: Reflexiones desde una asignatura de educación inclusiva
Authors: Cabrera-Cuadros Valeska , Soto-García Claudia , López-Carretero Asunción
Published: August 2021

Poner el foco en la formación docente para proyectar una escuela inclusiva es clave. El objetivo de la presente investigación es reflexionar sobre la incorporación del saber de la experiencia en la formación inicial del profesorado, usando como fuente el relato de una profesora que implementa una propuesta didáctica inclusiva. Se realizó un seguimiento durante un semestre en la asignatura Teoría y práctica de la escuela inclusiva, donde participaron 43 estudiantes de segundo año del Grado de Educación Infantil en la Universidad de Barcelona. La investigación es de tipo cualitativa con un enfoque de indagación narrativa, donde se diseñaron 4 fases para llegar al texto de investigación final; fase 1, registro de textos de campo; fase 2, elaboración de textos intermedios; fase 3, regreso al campo con el texto intermedio para nuevas reflexiones; fase 4, elaboración de los textos de investigación final que conforman este estudio. Los resultados muestran que el estudiantado se va aproximando a proyectos inclusivos desde una dimensión personal al interaccionar con saberes que parten de la experiencia y del autoconocimiento. Por otro lado, surgieron algunas tensiones: dificultad para actuar frente a las libertades otorgadas en la clase; inicialmente dificultades para compartir sus experiencias de manera oral y escrita, y necesidad de respuestas estandarizadas. El estudio permitió analizar una práctica educativa que se va forjando en la construcción de espacios de convivencia, la cual invita a nuevas reflexiones en torno al saber de la experiencia para pensar en la escuela inclusiva.
Aplicación del método Persistent Scatterer Interferometry (PSI) en la ciudad de Limón, Costa Rica
Authors: Paniagua-Jiménez Diana Ninette , Valverde-Calderón José , Molina-Calderón Paula , Barrantes-Castillo Gustavo
Published: August 2021

The objective of the present research was to apply the Persistent Scatterer Interferometry (PSI) method in the city of Limón, Costa Rica, in order to estimate surface deformation velocity. The investigation is of descriptive nature and use is made of radar imagery from the Sentinel-1 mission pre-processed with SNAP software of the European Space Agency. Line-of-sight (LOS) velocity and time series were estimated using the StaMPS software resulting in velocities in the range of -11 mm/yr5 to +20 mm/yr. It is concluded that the method has practical potential in Costa Rica for surface dynamics research and instances where no data is available from other methods such as GNSS.
Factores generadores de la disminución del turismo y afectaciones posteriores, zona costera Acapulco, México
Authors: Rivera-González Oscar Daniel
Published: August 2021

The following article analyzes the decrease in national and international tourism along the Acapulco coastal zone, causing adversities for inhabitants who sustain their economy on said activity and its economic contribution. Currently, based on theoretical and empirical research, a considerable decrease in tourism activity has been evidenced. This finding is ratified and quantified based on formal interviews with residents and tourists that point to excessive and unregulated early-stage urban growth as one triggering causative factor as it increases the generation of municipal solid waste, pollution, insecurity, violence and many other negative consequences mentioned throughout the article. The inaction and indifference of the authorities, mainly that of the Municipal Government of Acapulco and the Government of the State of Guerrero, encourage the progression of the aforementioned damaging issues. In view of the above, urgent measures are proposed to counter the deceleration of tourism in the port of Acapulco, which are to be applied urgently and effectively, with main consideration of the population, since otherwise it will become a forgotten and scantly visited port in the near future.
Aspectos biofísicos y socioeconómicos de la subcuenca del rio Páez, Cartago, Costa Rica
Authors: Alvarez Jiménez María , Ramírez-Granados Pablo , Castro-Solís José
Published: August 2021

The present study consisted in a characterization of biophysical and socioeconomic variables of the Páez River sub-basin, located in the norther sector of the city of Cartago, Costa Rica, with the purpose of generating baseline knowledge aimed at facilitating actors with decision-making tools and to propose water resource management guidelines for their eventual implementation. Quantitative and qualitative research techniques were used, including the application of a survey to 178 people in 10 localities geographically distributed in the upper, middle and lower sections of the sub-basin. The Páez River sub-basin covers an area of 28.34 km2 in the cantons of Oreamuno and Paraíso and over 50% of the territory is dedicated to agricultural activities and 16% to forest coverage. This geographical region presents important problems such as climatic vulnerability environmental pollution, governance issues, deficient diversification of economic activities, and thus poor diversity of employment opportunities in the region. The role of the Páez River sub-basin as a fundamental component for the supply of potable water and water for the development of productive activities is evidenced, the proposed characterization provides a baseline for determining adequate basin management methodologies.
Vulnerabilidad de la población de Guerrero, México, ante las epidemias de COVID-19 y dengue
Authors: Peña-Galeana Norma Ivone , Peña-Galeana Ricardo , Tello-Almaguer Pedro Vidal
Published: August 2021

The present article analyzes the situation of COVID-19 and dengue in the municipalities of the state of Guerrero, Mexico, as well as the situation of affected population groups classified by age and sex. Factors associated with prevention and control measures of both epidemics are also analyzed, including: availability of potable piped water, food sufficiency for minors and adults, and affiliation to health care services. Likewise, based on the aforementioned factors, a classification of the municipalities comprising the state of Guerrero is made according to the population’s level of vulnerability to both epidemics as a whole. Vulnerability is defined as the susceptibility of the population to be affected by COVID-19 and dengue given the situation of the studied factors.
Physical and chemical properties of Castanopsis fargesii wood after heat treatment in sand or vacuum media
Authors: Qi Wen-Yu , Liu Cai , Wu Xiao-Lian , Li Ji-Qing , Guan Xin , Lin Jin-Guo
Published: August 2021

Castanopsis fargesii is among the most prevalent hardwood species in South China. To improve the poor dimensional stability of C. fargesii wood, heat treatments were performed using vacuum or sand as the medium at four temperatures from 170 °C to 215 °C for 4 h. As a medium, vacuum or sand can create a low oxygen environment. The results showed that, as the temperature increased, the oven-dry density decreased, whereas the dimensional stability and the total color change (∆E*) increased with both media, two different changing patterns of a* and b* were observed, the lignin content increased, and the holocellulose content decreased. The oven-dry density decreased 9.4% and 25.5%, volume shrinkage ratio decreased 27.8% and 37.7%, and the ∆E* was 19.63 and 45.52, the lignin contents increased from 17.62% to 28.62% and 42.87%, and the holocellulose contents decreased from 80.49% to 69.43% and 51.04% when C. fargesii wood was heated under vacuum and with sand at 215 °C, respectively. Overall, sand heat treatment affected wood physical and chemical properties more than vacuum heat treatment. The analysis of functional groups and crystallinity also showed that there were severe changes in C. fargesii wood under sand heat treatment.
Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States
Authors: McCormick David W. , Richardson LaTonia Clay , Young Paul R. , Viens Laura J. , Gould Carolyn V. , Kimball Anne , Pindyck Talia , Rosenblum Hannah G. , Siegel David A. , Vu Quan M. , Komatsu Ken , Venkat Heather , Openshaw John J. , Kawasaki Breanna , Siniscalchi Alan J. , Gumke Megan , Leapley Andrea , Tobin-D’Angelo Melissa , Kauerauf Judy , Reid Heather , White Kelly , Ahmed Farah S. , Richardson Gillian , Hand Julie , Kirkey Kim , Larson Linnea , Byers Paul , Garcia Ali , Ojo Mojisola , Zamcheck Ariela , Lash Maura K. , Lee Ellen H. , Reilly Kathleen H. , Wilson Erica , de Fijter Sietske , Naqvi Ozair H. , Harduar-Morano Laurel , Burch Anna-Kathryn , Lewis Adele , Kolsin Jonathan , Pont Stephen J. , Barbeau Bree , Bixler Danae , Reagan-Steiner Sarah , Koumans Emilia H.
Published: August 2021

OBJECTIVES

To describe the demographics, clinical characteristics, and hospital course among persons <21 years of age with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–associated death.

METHODS

We conducted a retrospective case series of suspected SARS-CoV-2-associated deaths in the United States in persons <21 years of age during February 12 to July 31, 2020. All states and territories were invited to participate. We abstracted demographic and clinical data, including laboratory and treatment details, from medical records.

RESULTS

We included 112 SARS-CoV-2-associated deaths from 25 participating jurisdictions. The median age was 17 years (IQR 8.5–19 years). Most decedents were male (71, 63%), 31 (28%) were Black (non-Hispanic) persons, and 52 (46%) were Hispanic persons. Ninety-six decedents (86%) had at least 1 underlying condition; obesity (42%), asthma (29%), and developmental disorders (22%) were most commonly documented. Among 69 hospitalized decedents, common complications included mechanical ventilation (75%) and acute respiratory failure (82%). The sixteen (14%) decedents who met multisystem inflammatory syndrome in children (MIS-C) criteria were similar in age, sex, and race and/or ethnicity to decedents without MIS-C; 11 of 16 (69%) had at least 1 underlying condition.

CONCLUSIONS

SARS-CoV-2-associated deaths among persons <21 years of age occurred predominantly among Black (non-Hispanic) and Hispanic persons, male patients, and older adolescents. The most commonly reported underlying conditions were obesity, asthma, and developmental disorders. Decedents with coronavirus disease 2019 were more likely than those with MIS-C to have underlying medical conditions.
Editorial
Authors: Castañeda Rodríguez Víctor Mauricio
Published: August 2021

Como ya es una costumbre en Colombia, a lo sumo cada dos años se está debatiendo una nueva reforma tributaria, más aún hoy cuando la pandemia contribuyó al crecimiento tanto del déficit fiscal como de la deuda pública. Además, y aunque se pretenden legitimar algunos cambios en materia tributaria a partir del nombramiento e instalación de comisiones de expertos, al final los diagnósticos siempre se parecen y lo que se aprueba pocas veces guarda consistencia interna o coherencia con lo propuesto por el Gobierno. Al respecto, se puede recordar que la comisión de expertos tributarios que se creó a través de la Ley 1739 de 2014 planteaba en su informe, presentado a finales del 2015, que el sistema tributario colombiano era en exceso complejo, inequitativo e ineficiente, y en el 2020, cinco años después, el Ministerio de Hacienda y Crédito Público (MHCP, 2020) indicaba lo mismo, aunque con otras palabras, al manifestar que este “[…] tiene un espacio importante para mejorar en términos de progresividad, eficiencia y simplicidad” (p. 3).
La comunicación corporativa de la Responsabilidad Social Empresarial (RSE): El caso de las empresas de la provincia Sabana Centro de Cundinamarca, Colombia
Authors: Buitrago Betancourt Jeffer Darío
Published: August 2021

El objetivo de la investigación consistió en analizar el uso del portal web y las redes sociales para la comunicación corporativa de la responsabilidad social empresarial (rse) por parte de las empresas localizadas en la provincia Sabana Centro del departamento de Cundinamarca. Se aplicó metodología exploratoria con enfoque cualitativo y técnica de análisis de contenido para la revisión de portales web corporativos y redes sociales de 369 empresas localizadas en cinco municipios de Sabana Centro. Se pudo concluir que las empresas grandes y medianas superan ampliamente a las micro y pequeñas en hacer uso de dichos medios para comunicar sus acciones de rse, sin embargo, en términos globales, el porcentaje de comunicación de esta temática es bajo en todas las empresas, independientemente de su tamaño. Otra conclusión relevante es que, comparadas con empresas de otros sectores, las que realizan explotación de minas y canteras son las que en menor proporción comunican en portal web y redes sociales sus acciones de rse, lo cual resulta paradójico, pues regularmente soportan mayor presión social por los posibles impactos generados en el desarrollo de su actividad económica y se esperaría que utilizaran mayormente estos medios para elevar su reputación.
Relaciones con la organización y el trabajo en los millennials colombianos
Authors: Gallo Oscar , Gonzales-Miranda Diego René , Román-Calderón Juan Pablo , García Gustavo Adolfo
Published: August 2021

La literatura reciente sugiere una pérdida de la hegemonía del trabajo en la vida y una concepción policéntrica de la existencia. El propósito de este artículo es reflexionar sobre el significado y la relación que establecen los millennials colombianos con el trabajo y las organizaciones. Con ese objetivo, se analizaron 219 entrevistas a milennials y no millennials, perteneciente a once empresas colombianas con presencia en las cinco principales ciudades del país. Para el análisis del contenido, se utilizó Atlas.Ti, versión 8.2. Se concluye que entre los millennials colombianos no existe un tipo de relación con las organizaciones y un significado del trabajo homogéneo. La relación oscila entre lo expresivo y lo pragmático, y está determinada por variables socioculturales más que generacionales. Aportar al conocimiento de las relaciones con las organizaciones en los millennials colombianos es evidenciar las inconsistencias y riesgos de promover acciones organizacionales basadas en la asimilación descontextualizada de los resultados de investigaciones provenientes de otros países.
Fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with concurrent ulcerative colitis
Authors: Gholam-Mostafaei Fahimeh Sadat , Yadegar Abbas , Asadzadeh Aghdaei Hamid , Shahrokh Shabnam , Ebrahimi Daryani Nasser , Zali Mohammad Reza
Published: August 2021

Treatment of recurrent Clostridioides difficile infection (rCDI) has emerged as an important management dilemma particularly in patients with underlying inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been used as a safe and highly effective treatment option for rCDI refractory to standard antibiotic therapies. The aim of this study was to report the efficacy of FMT in Iranian rCDI patients with concurrent IBD. A total of seven consecutive patients with ulcerative colitis (UC) who had experienced 3 episodes of rCDI were enrolled in this study. All patients received at least a single FMT administered during colonoscopy by direct infusion of minimally processed donor stool. Patients were followed for a minimum of 6 months for assessment of treatment efficacy and adverse events (AEs) attributable to FMT. All 7 UC patients (100%) experienced a durable clinical response to a single FMT following 2 months after the procedure. One patient received a second FMT in which a successful resolution of rCDI was ultimately achieved. No serious AEs from FMT were noted. FMT through colonoscopy was a safe, simple and effective alternative treatment approach for rCDI in patients with underlying IBD. However, its use and efficacy should be pursued in long-term prospective controlled trials.
Ex vivo Resection for Renal Cancer: Indications and Results in Specific Clinical Scenarios
Authors: Coco Danilo , Leanza Silvana
Published: August 2021

Purpose: To retrospectively evaluated databases for indications and results of “bench surgery Technique” in ex vivo or ex situ renal cancer resection as a lost alternative of savage renal function in renal malignancy.
Materials and methods:We have retrospectively evaluated PUBMED databases. Studies was evaluated from 2010 to 2020.Only very few studies analyzed a
Conclusion: Ex vivo Renal Resection and Autotransplantation (ERRA) is the lost chance in patient with renal cancer and demonstrated numerous problems during and after surgery.We noted that in some patients, however, it provided good control of the cancer,avoided  long-term dialysis, avoided renal transplantation giving to the patients a good quality of life.
Uso de linkage para análise de completude e concordância de óbitos por sífilis congênita na Região Metropolitana de São Paulo, 2010-2017: estudo descritivo
Authors: Almeida Ana Beatriz Machado de , Silva Zilda Pereira da
Published: August 2021

Resumo Objetivo: Avaliar a completude e concordância dos óbitos infantis por sífilis congênita na Região Metropolitana de São Paulo, Brasil, no período 2010-2017. Métodos: Estudo descritivo, baseado na vinculação do Sistema de Informações sobre Mortalidade (SIM) com o Sistema de Informações sobre Nascidos Vivos (Sinasc). Foram considerados os óbitos com menção de sífilis congênita nas causas múltiplas de morte. Analisou-se a completude de 11 variáveis do SIM; adotou-se o Sinasc como referência. Para análise da concordância, utilizou-se o índice Kappa. Resultados: Registraram-se 134 óbitos por sífilis congênita; destes, 132 foram vinculados, sendo 67 como causa básica e 65 ao se considerar causas múltiplas de óbito, indicando subestimação da mortalidade. Após linkage, houve aumento de 2 para 10 variáveis com preenchimento excelente. Conclusão: A vinculação do SIM com dados do Sinasc melhorou sua completude. Identificou-se subestimação da magnitude da mortalidade por sífilis congênita, e o uso das causas múltiplas melhorou sua mensuração.
EMPREENDEDORISMO NA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA: A CONSTRUÇÃO DE UM MATERIAL EDUCATIVO
Authors: Teodoro Eduani de Cássia Souza , Neves Rafael Felipe Coelho , Marcusso Marcus Fernandes
Published: August 2021

A criação de produtos educacionais no contexto da Educação Profissional e Tecnológica não pode ignorar as bases epistemológicas da modalidade. Também deve buscar as percepções dos alunos para localizar aspectos importantes da prática social dos temas de aprendizagem. Esse movimento possibilita a criação de propostas de intervenção contextualizadas, significativas, dotadas de potencial para impactar a realidade. No entanto, esse contato com os alunos deve ser mediado pelo olhar investigativo e atento do professor, que pode utilizar instrumentos de pesquisa para realizar essa mediação. Este artigo mostra como um estudo diagnóstico forneceu subsídios fundamentais para a construção de uma proposta de eixo conceitual, de eixo pedagógico e de eixo comunicacional de um material didático adequado para explorar o tema empreendedorismo com alunos de um curso técnico em administração. Nesse sentido, um questionário semiestruturado foi elaborado. Esse instrumento investigou o perfil socioeconômico dos alunos, a relação dos respondentes com o mundo do trabalho, com a escola, com o curso e com a prática social do empreendedorismo. A análise descritiva e de conteúdo das respostas indicou que as atividades práticas podem aumentar a motivação dos alunos para a aprendizagem de temas relacionados com o empreendedorismo, sugerindo, assim, a utilização de metodologias ativas.
Does traffic really disappear when roads are closed?
Authors: Melia Steve , Calvert Tom
Published: August 2021

This paper describes two studies that aimed to explore the impacts of pedestrianisation or road closures on traffic displacement, travel behaviour and the phenomenon of ‘disappearing traffic’. The first study surveyed residents whose travel routes were affected by a small-scale localised pedestrianisation scheme in the centre of a town. The second measured the traffic impacts of a temporary closure of a strategic bridge in a city centre. In the first case, the pedestrianisation produced no change in the modal shares of travel of residents. Drivers continued to drive to the same locations by longer routes. In the second case, the closure caused some traffic displacement and increased journey times but also reduced traffic volumes in both the immediate area and across the city. This paper concludes by discussing the remaining knowledge gaps on disappearing traffic, made more pressing by the decisions of authorities to reallocate road space during the coronavirus disease 2019 crisis.
Political and legal risks in public–private partnership mega transportation projects
Authors: Aladağ Hande , Işik Zeynep
Published: August 2021

In Public-Private-Partnership (PPP) projects, all stakeholders may be exposed to losses due to changes in political and legal environment which certainly affect the success targets of the PPP projects. Hence, this paper aims to determine political and legal risks and identify the effect of those risks on the success of PPP mega transportation projects. Thus, the risks were determined within a systematic literature review and focus group discussion were carried out for validation. Then, an illustrative case study in Turkey was presented to better illustrate the effects of political and legal environment. Finally, Fuzzy Analytical Hierarchy Process (FAHP) method was used to identify the significance of the identified risks. The prominent risks were found out as termination of concession by public institution, political opposition, failure/delay in obtaining permit/approval and expropriation. The evolution of determined risks with an associated case from a mega transportation project contributes to the PPP project practitioners about possible challenges in developing countries where political and legal instability is widespread. Considering the focus on transportation projects constitutes the limitation of this study, the research opens future evaluations by testing identified political and legal risks for other different kind of PPP-type projects to identify if any different perceptions exist.
Habilidades sociais e coworking: Possibilidade ou necessidade?
Authors: Bohnenberger Luís Augusto , Pante Marina
Published: August 2021

O coworking é uma tendência mundial que vem crescendo no Brasil. Mais que um local de trabalho, é um ambiente de colaboração, criatividade e inovação e que favorece a networking.  Porém para que a pessoa possa usufruir dessas possibilidades, é necessário que tenha algumas habilidades sociais desenvolvidas e aplicadas. Neste artigo, se buscou entender como se dão as relações interpessoais no coworking, como é a qualidade dessas relações e se dependem de a pessoa possuir um repertório de habilidades sociais previamente desenvolvidas ou se o coworking pode ser um local de desenvolvimento de habilidades sociais. Para isto, realizaram-se dez entrevistas semiestruturadas com profissionais de diferentes áreas que trabalham num coworking, convidando pessoalmente cada um deles. Estas entrevistas que com foram exploradas através da Análise de Conteúdo de Bardin (1977), sob as categorias de: (1) habilidades sociais, (2) comportamentos não-assertivos/agressivos, (3) visão de coworking e (4) outros. Faz-se uma revisão sobre as principais características do coworking, que é apontado como um local que favorece o sentimento de comunidade, além de um entendimento da importância das habilidades sociais. Como resultados, verificou-se que é necessário tanto um desenvolvimento prévio de habilidades sociais para se integrar ao coworking quanto a disposição do profissional para desenvolver suas habilidades sociais na convivência com outras pessoas que compartilham o mesmo espaço. Conclui-se que este pode ser um campo de atuação para o psicólogo no sentido de auxiliar no desenvolvimento de habilidades sociais.
Impactos da pandemia da COVID-19 na saúde mental dos estudantes universitários
Authors: Sunde Rosário Martinho
Published: August 2021

Este é um artigo de revisão narrativa da literatura, o qual tem por objetivo avaliar os impactos da pandemia da Covid-19 na saúde mental de estudantes universitários. A busca de dados ocorreu durante o mês de março de 2021, em 3 bases (Science Direct, BVS e PubMed). Foram encontrados um total de 755 artigos usando os descritores “Impact and Covid-19 and Mental Health and University student”, dos quais, depois do processo de inclusão e exclusão, sobraram 11 estudos, que foram explorados na íntegra para análise final, sob a perspectiva qualitativa de análise de conteúdo de Saldaña (2013). Os resultados deste estudo nos conduzem a concluir que a pandemia da Covid-19 afeta grandemente a saúde mental dos estudantes universitários. Desde que a doença foi considerada uma pandemia mundial, as atividades acadêmicas nas universidades foram encerradas (aulas, exames de qualificação de pós-graduação, defesas e outras) para contenção do vírus. Os riscos e impactos à saúde mental neste período incluem o medo de contaminação pelo vírus, a incerteza sobre o fim da pandemia e o retorno das aulas, medidas de distanciamento social prolongado, ansiedade e outros desconfortos psicológicos agravados pela falta de serviços de apoio psicológico. Sugere-se, assim, a implementação de serviços de apoio psicológico (sendo a modalidade virtual mais eficaz neste momento da pandemia) dentro das universidades, para a promoção do bem estar e da saúde mental da população universitária.
Riscos psicossociais no trabalho de auxiliares de cozinha de uma indústria
Authors: Rüedell Fabieli Tais , Gonçalves Júlia
Published: August 2021

A Psicodinâmica do Trabalho, abordagem teórica deste estudo, destaca a importância e influência do contexto de trabalho nos processos de saúde e adoecimento do trabalhador. Nessa perspectiva, os riscos psicossociais no trabalho são compreendidos como fatores que se relacionam com as percepções dos trabalhadores acerca da organização do trabalho, da gestão, do sofrimento e dos problemas emocionais, físicos e psíquicos. Esta pesquisa mapeou os riscos psicossociais em auxiliares de cozinha de uma indústria localizada no interior Rio Grande do Sul. Foi realizada uma pesquisa quantitativa e descritiva, em que 28 auxiliares de cozinha responderam à um questionário de dados sociodemográficos e ao Protocolo de Avaliação dos Riscos Psicossociais no Trabalho (PROART). Os dados foram analisados a partir da estatística descritiva. Os resultados obtidos destacaram os elevados riscos psicossociais presentes na organização do trabalho, em especial relacionados as condições, prazos, ritmos, normas, responsabilidades e divisão do trabalho. Por outro lado, o estilo de gestão coletivista foi assinalado como o mais presente, ou seja, há uma percepção de que os gestores da empresa valorizam o trabalho em grupo, reconhecem as conquistas como mérito de todos e levam em conta o bem-estar dos trabalhadores.  Estudos com categorias profissionais que, muitas vezes, são invisibilizadas – com a de auxiliares de cozinha - são essenciais, pois propiciam um reconhecimento da importância da função para o funcionamento da empresa, bem como podem fornecer subsídios teóricos para que a gestão promova ações de melhoria das condições e da organização do trabalho desses profissionais.
Seasonal changes in photosynthesis for the epiphytic bromeliad Tillandsia brachycaulos in a tropical dry deciduous forest
Authors: González Salvatierra Claudia , Peña-Rodríguez Luis Manuel , Reyes-García Casandra , De la Barrera Erick , Andrade José  Luis
Published: August 2021

Background: Sunlight stress and drought affect plants by inducing various biochemical and physiological responses, which reduce growth. Seasonal changes in light and water availability that occur in forest canopies, where epiphytes occur, are extreme.
Questions: What are the seasonal changes in photosynthesis for an abundant epiphytic bromeliad in contrasting microenvironments? Is Crassulacean acid metabolism (CAM) an important feature of photoprotection for this epiphyte?
Studied species: Tillandsia brachycaulos Schltdl. (Bromeliaceae)
Study site and dates: Canopy of the tropical dry deciduous forest of Dzibilchaltún National Park, Yucatan, Mexico during the rainy season 2008 and dry season 2009.
Methods: Diurnal measurements of photosystem II efficiency, titratable acidity, leaf water potential, and photosynthetic pigment concentration were measured during the dry and rainy seasons in adult plants of T. brachycaulos in shaded and exposed microenvironments. The prevailing environmental conditions (photon flux density, precipitation, air temperature and relative humidity) were also seasonally characterized.
Results: The highest irradiance occurred during the dry season caused photo-inactivation, a decrease of the quantum efficiency of photosystem II and a reduction in CAM activity of about 40 % in leaves of exposed plants of T. brachycaulos. During the rainy season, the leaf water potential of exposed and shaded plants of T. brachycaulos was lower at midday than at predawn, indicating water loss during the day.
Conclusions: Individuals of T. brachycaulos reduced CAM activity during the dry season; and, during the rainy season, increased carbon gain by stomata opening during phase II and IV of CAM.
Ateş çiçeğinde (Salvia splendens) yetiştirme ortamı olarak fındık zurufunun kullanımı
Authors: ÇİÇEK Nuray , YÜCEDAĞ Cengiz
Published: August 2021

Bu çalışmada, Ateş çiçeğinin büyüme ve kalite parametreleri, fotosentetik pigmentleri ile besin maddesi içerikleri üzerine fındık zurufunun etkilerinin belirlenmesi amaçlanmıştır. Bu amaçla, Ateş çiçeği fideleri kontrol (%100 torf) ve farklı oranlarda fındık zurufu içeren altı yetiştirme ortamında beş yinelemeli olarak denenmiştir. Bitkilerde estetik görünümü, taç genişliği, çiçek sayısı ve ağırlığı, ana sürgün sayısı, bitki boyu, bitki yaş ve kuru ağırlıkları, kök yaş ve kuru ağırlıkları, klorofik a ve b, klorofil a+b, karotenoid, klorofil a+b/karotenoid ve besin içerikleri (N, P, K, Ca, Mg, Fe, Cu, Zn ve Mn) tespit edilmiştir. Ateş çiçeğinin kalsiyum, magnezyum ve demir dışındaki tüm özellikleri üzerine fındık zurufunun etkili olduğu ortaya çıkmıştır. Çalışmadaki özelliklerin en yüksek ortalama değerleri “%50 Torf/Perlit+%50 Fındık Zurufu” ortamından elde edilmiş olduğu için, ateş çiçeği için bu yetiştirme ortamı kullanılabilir. Ayrıca, deneme boyunca bitkilerde herhangi bir bitki besin maddesi noksanlığı gözlenmemiştir ancak bütün ortamlarda mangan değerinin düşük olması nedeni ile gübreleme programında mangan önerilebilir.
Single-cell ATAC sequencing v1
Authors: H. Kaestner Lab Klaus , Shapira Suzanne
Published: August 2021

Interrogating cell-type specific chromatin accessibility can reveal cis-regulatory elements linked to downstream gene expression patterns. Assay for Transposase-Accessible Chromatin using Sequencing (ATAC-Seq) is a technique that assays genome-wide chromatin accessibility and can reveal nucleosome positioning patterns, map enhancer and promoter regions, or reveal transcription factor binding sites. Single-cell Assay for Transposase-Accessible Chromatin using Sequencing (scATAC-seq) adapts the bulk ATAC-sequencing protocol to separate individual nuclei and assay chromatin state with single-cell resolution. This technique allows for resolution of gene accessibility patterns within specific pancreatic cell types such as α-cells, β-cells, and acinar cells.
Single-cell RNA sequencing v1
Authors: H. Kaestner Lab Klaus , Shapira Suzanne
Published: August 2021

Single-cell RNA sequencing (scRNA-seq) allows for transcriptional profiling of individual cells within a heterogenous sample. This protocol describes a method for performing scRNA-seq using handpicked pancreatic islets from organ donors.
Protocol forTransfection of Bodo saltans with SaCas9 RNP complex in conjunction with eGFP-NEO plasmid by electroporation v1
Authors: Gomaa Fatma
Published: August 2021

Developing transfection protocol for Bodo saltans, using SaCas9/sgRNA ribonucleoprotein (RNP) complex in conjunction with DNA repair template to disrupt the Paraflagellar rod 2 gene (BsPFR2) and increase the efficiency of targeted homologous recombination when a repair template DNA is provided. The exogenous repair template is double stranded DNA and it consists of eGFP fused with the drug selection gene nptII/neo and flanked by 500 bp of the untranslated regions (UTRs) upstream and downstream of the targeted BsPFR2 as homologous repair arms.
Protocol for RNA isolation and RT‐PCR confirmation for Neomycin gene expression in transformed Bodo saltans v1
Authors: Gomaa Fatma
Published: August 2021

Developing transfection protocol for Bodo saltans, using SaCas9/sgRNA ribonucleoprotein (RNP) complex in conjunction with DNA repair template to disrupt the Paraflagellar rod 2 gene (BsPFR2) and increase the efficiency of targeted homologous recombination when a repair template DNA is provided. The exogenous repair template is double stranded DNA and it consists of eGFP fused with the drug selection gene nptII/neo and flanked by 500 bp of the untranslated regions (UTRs) upstream and downstream of the targeted BsPFR2 as homologous repair arms.
Post-Flood Impact on the Quality of Life of Victims in East Coast Malaysia
Authors: Mohammed Nawi Azmawati , Wan Puteh Sharifa Ezat , Hod Rozita , Badilla Idris Idayu , Ahmad Izzah Syazwani , Mohd Ghazali Qistina
Published: August 2021

Objective: This study aimed to evaluate the quality of life among flood victims exposed at three worst districts in Pahang, Malaysia. Methods: Semi-guided questionnaires were distributed randomly to a total of 602 flood victims. Quality of life (QOL) was measured using WHO Quality of Life-BREF (WHOQOL-BREF), which were assessed based on four domains, i.e. physical activity, psychological, social relationships and environment. Results: Victims of the flood had a poorer quality of life in all the domains especially physical (59.0%) and psychological (53.3%) domain. The impact of the flood on QOL was higher among women, those who reside in the urban area, the elderlies and persons with high education and income. Conclusion: Flood event has reduced the QOL of victims. The impact of flood has been found to be mitigated over the time and relief efforts. Interventions aimed to reduce these concerns in acute post-flood areas are essential to minimize poor QOL among the affected victims. Keywords: Flood, WHOQOL-BREF, Malaysia, victim, QOL, urban
The Procedural Laboratory for Studying the Historical Types of Criminal Proceedings
Authors: Lamteva Anna V.
Published: August 2021

The article is devoted to the study of historical types of criminal proceedings in a vertical direction. The foremost archetypes of criminal procedure, which laid the technological and methodological foundations for formation of the investigative, adversarial, and mixed types of criminal proceedings, were analyzed. Arguments are given in favor of the fact that the initial reference point for criminal proceedings is the accusatory-adversarial type. The appropriate legal examples from the legislation of Athens and Ancient Rome are referenced in the article. An attempt is made to prove three hypotheses about the modern types of criminal procedure, the sequential system about the models of criminal procedure. Consideration is given to the archetype. The debatable issue regarding the active and passive positions of judges in the resolution of criminal cases on their merits was considered. The author's position in favor of the role of a judge as a non-initiative arbitrator between the parties was appropriate and justified only in the times of the rise of Athens and Ancient Rome. The judicial compositions of each case consisted of several hundred judges, which made it possible to make the right decision. The judges themselves were from the people. In particular, this is why, before our era, there were no dubious statistics in court proceedings from the point of view of the adversarial principle. It further explains why there were both convictions and acquittals in sufficient numbers for a democratic state. The modern procedural role of a judge is often reduced to the personal neutral, but at the same time active investigation of the evidence is presented by the parties. Much attention is given to the modern type of criminal process, which is called mixed. This content is considered in two ways as a symbiosis of investigative and adversarial types and also as a procedural duet of accusatory-adversarial and techno-centric models.
ANALISIS TINGKAT LITERASI LINGKUNGAN SISWA PADA MUATAN LOKAL PENDIDIKAN LINKUNGAN HIDUP
Authors: Aini Nur , Al Muhdhar Mimien Henie Irawati , Rochman Fatchur , Sumberartha I Wayan , Wardhani Wenny , Mardiyanti Lely
Published: August 2021

Abstrak. Tujuan dari penelitian ini adalah untuk mengetahui tingkat literasi lingkungan siswa kelas X IPA 1 SMAN 3 Jombang pada muatan lokal pendidikan lingkungan hidup. Penelitian ini tergolong deskriptif kualitatif. Populasi penelitian adalah seluruh siswa kelas X IPA SMAN 3 Jombang. Sampel penelitian ditentukan dengan purposive sampling yaitu kelas X IPA 1. Hasil penelitian dijabarkan sebagai berikut, literasi lingkungan siswa termasuk dalam kategori cukup dengan rerata skor sebesar 75. Indikator pengetahuan termasuk dalam kategori baik dengan rerata skor 80. Indikator keterampilan kognitif, sikap, dan perilaku termasuk dalam kategori cukup dengan masing-masing rerata skor  yaitu 75, 74, dan 72. Pembelajaran pada muatan lokal pendidikan lingkungan hidup berdampak pada peningkatan literasi lingkungan siswa akan tetapi tidak memberikan perbedaan yang signifikan.Abstract. The aim of this study was to determine the level of environmental literacy of students class X Science 1 of SMAN 3 Jombang on the local content of environmental education. This research is classified as qualitative descriptive. The study population was all students of class X IPA SMAN 3 Jombang. The research sample was determined by purposive sampling, namely class X IPA 1. The results of the study are described as follows, environmental literacy of students is included in the category of sufficient with a mean score of 75. Indicators of ecological knowledge are categorized well with a mean score of 80. Indicators of cognitive skills, attitudes, and behavior included in the category enough with each average score of 75, 74, and 72. Learning on the local content of environmental education has an impact on increasing environmental literacy of students but does not make a significant difference.