bluuebunny/crossref_metadata_2025 huggingface dataset:
Disruption of Crystal Packing in Thieno[2,3-b]pyridines Improves Anti-Proliferative Activity
Authors: Haverkate Natalie A. , Leung Euphemia , Pilkington Lisa I. , Barker David
Published: January 2022

3-Amino-2-arylcarboxamido-thieno[2,3-b]pyridines have been shown to have anti-proliferative activity, but are also known to have poor solubility. This has been previously proposed to be due to their extensive planarity, which allows for intermolecular stacking and crystal packing. We herein report the synthesis of fifteen novel thieno[2,3-b]pyridines that have incorporated bulky, but easily cleavable, ester and carbonate functional groups in an effort to decrease crystal packing. The addition of these ‘prodrug-like’ moieties into the thieno[2,3-b]pyridine resulted in compounds with increased activity against HCT-116 colon cancer cells and the triple-negative breast cancer cell line MDA-MB-231.
Research of Nanomaterials as Electrodes for Electrochemical Energy Storage
Authors: Yazvinskaya Nataliya N. , Lipkin Mikhail S. , Galushkin Nikolay E. , Galushkin Dmitriy N.
Published: January 2022

This paper has experimentally proved that hydrogen accumulates in large quantities in metal-ceramic and pocket electrodes of alkaline batteries during their operation. Hydrogen accumulates in the electrodes in an atomic form. After the release of hydrogen from the electrodes, a powerful exothermic reaction of atomic hydrogen recombination with a large energy release occurs. This exothermic reaction is the cause of thermal runaway in alkaline batteries. For the KSL-15 battery, the gravimetric capacity of sintered nickel matrix of the oxide-nickel electrode, as hydrogen storage, is 20.2 wt%, and cadmium electrode is 11.5 wt%. The stored energy density in the metal-ceramic matrix of the oxide-nickel electrode of the battery KSL-15 is 44 kJ/g, and in the cadmium electrode it is 25 kJ/g. The similar values for the KPL-14 battery are as follows. The gravimetric capacity of the active substance of the pocket oxide-nickel electrode, as a hydrogen storage, is 22 wt%, and the cadmium electrode is 16.9 wt%. The density of the stored energy in the active substance oxide-nickel electrode is 48 kJ/g, and in the active substance of the cadmium electrode it is 36.8 kJ/g. The obtained results of the accumulation of hydrogen energy in the electrodes by the electrochemical method are three times higher than any previously obtained results using the traditional thermochemical method.
One-Pot Synthesis of Novel 2-Imino-5-Arylidine-Thiazolidine Analogues and Evaluation of Their Anti-Proliferative Activity against MCF7 Breast Cancer Cell Line
Authors: Aziz Marian N. , Patel Arzoo , Iskander Amany , Chini Avisankar , Gout Delphine , Mandal Subhrangsu S. , Lovely Carl J.
Published: January 2022

An efficient surface-mediated synthetic method to facilitate access to a novel class of thiazolidines is described. The rationale behind the design of the targeted thiazolidines was to prepare stable thiazolidine analogues and evaluate their anti-proliferative activity against a breast cancer cell line (MCF7). Most of the synthesized analogues exhibited increased potency ranging from 2–15-fold higher compared to the standard reference, cisplatin. The most active thiazolidines contain a halogenated or electron withdrawing group attached to the N-phenyl ring of exocyclic 2-imino group. However, combination of the two substituents did not enhance the activity. The anti-proliferative activity was measured in terms of IC50 values using an MTT assay.
Trifluoroethanol Promoted Castagnoli–Cushman Cycloadditions of Imines with Homophthalic Anhydride
Authors: Bayles Thibault , Guillou Catherine
Published: January 2022

Lactams are essential compounds in medicinal chemistry and key intermediates in the synthesis of natural products. The Castagnoli–Cushman reaction (CCR) of homophthalic anhydride with imines is an exciting method for accessing cyclic densely substituted lactam products. Most CCRs need to be catalyzed or heated. Herein, we report a new, efficient, metal and catalyst-free CCR for the synthesis of poly-substituted 3,4-lactams utilizing the unique properties of trifluoroethanol (TFE). This procedure provides high-speed and smooth access to a broad range of densely substituted 3,4-lactams in good yields and a 100% atom-economical fashion.
From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects
Authors: Sykuła Anna , Łodyga-Chruścińska Elżbieta , Garribba Eugenio , Kręgiel Dorota , Dzeikala Aliaksandr , Klewicka Elżbieta , Piekarska-Radzik Lidia
Published: January 2022

Microorganisms are able to give rise to biofilm formation on food matrixes and along food industry infrastructures or medical equipment. This growth may be reduced by the application of molecules preventing bacterial adhesion on these surfaces. A new Schiff base ligand, derivative of hesperetin, HABH (2-amino-N′-(2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene)benzohydrazide), and its copper complex, CuHABH [CuLH2(OAc)], were designed, synthesized and analyzed in terms of their structure and physicochemical properties, and tested as antibacterial agents. Their structures both in a solid state and in solution were established using several methods: FT-IR, 1H NMR, 13C NMR, UV-Vis, FAB MS, EPR, ESI-MS and potentiometry. Coordination binding of the copper(II) complex dominating at the physiological pH region in the solution was found to be the same as that detected in the solid state. Furthermore, the interaction between the HABH and CuHABH with calf-thymus DNA (CT-DNA) were investigated. These interactions were tracked by UV-Vis, CD (circular dichroism) and spectrofluorimetry. The results indicate a stronger interaction of the CuHABH with the CT-DNA than the HABH. It can be assumed that the nature of the interactions is of the intercalating type, but in the high concentration range, the complex can bind to the DNA externally to phosphate residues or to a minor/major groove. The prepared compounds possess antibacterial and antibiofilm activities against Gram-positive and Gram-negative bacteria. Their antagonistic activity depends on the factor-strain test system. The glass was selected as a model surface for the experiments on antibiofilm activity. The adhesion of bacterial cells to the glass surface in the presence of the compounds was traced by luminometry and the best antiadhesive action against both bacterial strains was detected for the CuHABH complex. This molecule may play a crucial role in disrupting exopolymers (DNA/proteins) in biofilm formation and can be used to prevent bacterial adhesion especially on glass equipment.
Extraction and Study of Hypoglycemic Constituents from Myrica rubra Pomace
Authors: Chang Guoli , Cai Chenggang , Xiang Yannan , Fang Xiangjun , Yang Hailong
Published: January 2022

Myrica rubra pomace accounts for 20% of the fruit’s weight that is not utilized when it is juiced. The pomace contains bioactive phenolic substances such as anthocyanins and flavonoids. To improve the utilization value of Myrica rubra pomace, an optimized extraction method for the residual polyphenols was developed using response surface methodology (RSM). The resulting extract was analyzed by high performance liquid chromatography (HPLC), and the in vitro hypoglycemic activity and antioxidant activity of the polyphenolic compounds obtained were also investigated. The optimum extraction conditions (yielding 24.37 mg·g−1 total polyphenols content) were: extraction temperature 60 °C, ultrasonic power 270 W, ethanol concentration 53%, extraction time 57 min, and solid to liquid ratio 1:34. Four polyphenolic compounds were identified in the pomace extract by HPLC: myricitrin, cyanidin-O-glucoside, hyperoside, and quercitrin. DPPH and hydroxyl radical scavenging tests showed that the Myrica rubra polyphenols extract had strong antioxidant abilities. It is evident that the residual polyphenols present in Myrica rubra pomace have strong hypoglycemic activity and the juiced fruits can be further exploited for medicinal purposes.
The Synergistic Effect of Triterpenoids and Flavonoids—New Approaches for Treating Bacterial Infections?
Authors: Wrońska Natalia , Szlaur Michał , Zawadzka Katarzyna , Lisowska Katarzyna
Published: January 2022

Currently, the pharmaceutical industry is well-developed, and a large number of chemotherapeutics are being produced. These include antibacterial substances, which can be used in treating humans and animals suffering from bacterial infections, and as animal growth promoters in the agricultural industry. As a result of the excessive use of antibiotics and emerging resistance amongst bacteria, new antimicrobial drugs are needed. Due to the increasing trend of using natural, ecological, and safe products, there is a special need for novel phytocompounds. The compounds analysed in the present study include two triterpenoids ursolic acid (UA) and oleanolic acid (OA) and the flavonoid dihydromyricetin (DHM). All the compounds displayed antimicrobial activity against Gram-positive (Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, and Listeria monocytogenes ATCC 19115) and Gram-negative bacteria (Escherichia coli ATCC 25922, Proteus hauseri ATCC 15442, and Campylobacter jejuni ATCC 33560) without adverse effects on eukaryotic cells. Both the triterpenoids showed the best antibacterial potential against the Gram-positive strains. They showed synergistic activity against all the tested microorganisms, and a bactericidal effect with the combination OA with UA against both Staphylococcus strains. In addition, the synergistic action of DHM, UA, and OA was reported for the first time in this study. Our results also showed that combination with triterpenoids enhanced the antimicrobial potential of DHM.
Tetra-2,3-Pyrazinoporphyrazines with Externally Appended Pyridine Rings 22 Synthesis, Physicochemical and Photoactivity Studies on In(III) Mono- and Heteropentanuclear Complexes
Authors: Donzello Maria Pia , Capobianco Giulia , Pettiti Ida , Ercolani Claudio , Stuzhin Pavel A.
Published: January 2022

The basic macrocyclic octapyridinotetrapyrazinoporphyrazine InIII complex of formula [Py8TPyzPzIn(OAc)]·8H2O, prepared by reaction of the free ligand [Py8TPyzPzH2]·2H2O with In(OAc)3, is a stable-to-air species of which the structure has been studied by its X-ray powder diffraction and mass spectra and characterization operated by IR and UV-visible spectral behavior. The complex has been further examined and proven to be of potential interest for its response as an anticancer agent in the field of photodynamic therapy (PDT), the value of ΦΔ = 0.55 (in DMF) being in the range of 0.4–0.6 at the level of similar phthalocyanine and porphyrazine analogs and qualifying the species as a highly efficient anticancer agent. Planned parallel types of investigation, including their photoactive behaviour in PDT, have been extended to the mononuclear octacation [(2-Mepy)8TPyzPzIn(OAc)]8+ (salted by iodide ions) and the heteropentanuclear derivatives [(M’Cl2)4Py8TPyzPzIn(OAc)]·xH2O (M’ = PdII, x = 8; PtII, x = 1)) and [{(Pd(CBT)2)4}Py8TPyzPzIn(OAc)]·19H2O (CBT = m-carborane-1-thiolate anion).
Experimental Investigation on Thermophysical Properties of Ammonium-Based Protic Ionic Liquids and Their Potential Ability towards CO2 Capture
Authors: Zailani Nur Hidayah Zulaikha Othman , Yunus Normawati M. , Ab Rahim Asyraf Hanim , Bustam Mohamad Azmi
Published: January 2022

Ionic liquids, which are extensively known as low-melting-point salts, have received significant attention as the promising solvent for CO2 capture. This work presents the synthesis, thermophysical properties and the CO2 absorption of a series of ammonium cations coupled with carboxylate anions producing ammonium-based protic ionic liquids (PILs), namely 2-ethylhexylammonium pentanoate ([EHA][C5]), 2-ethylhexylammonium hexanoate ([EHA][C6]), 2-ethylhexylammonium heptanoate ([EHA][C7]), bis-(2-ethylhexyl)ammonium pentanoate ([BEHA][C5]), bis-(2-ethylhexyl)ammonium hexanoate ([BEHA][C6]) and bis-(2-ethylhexyl)ammonium heptanoate ([BEHA][C7]). The chemical structures of the PILs were confirmed by using Nuclear Magnetic Resonance (NMR) spectroscopy while the density (ρ) and the dynamic viscosity (η) of the PILs were determined and analyzed in a range from 293.15K up to 363.15K. The refractive index (nD) was also measured at T = (293.15 to 333.15) K. Thermal analyses conducted via a thermogravimetric analyzer (TGA) and differential scanning calorimeter (DSC) indicated that all PILs have the thermal decomposition temperature, Td of greater than 416K and the presence of glass transition, Tg was detected in each PIL. The CO2 absorption of the PILs was studied up to 29 bar at 298.15 K and the experimental results showed that [BEHA][C7] had the highest CO2 absorption with 0.78 mol at 29 bar. The CO2 absorption values increase in the order of [C5] < [C6] < [C7] anion regardless of the nature of the cation.
Impact of Ageing on Pea Protein Volatile Compounds and Correlation with Odor
Authors: Fischer Estelle , Cachon Rémy , Cayot Nathalie
Published: January 2022

Vegetal proteins are of high interest for their many positive aspects, but their ‘beany’ off-flavor is still limiting the consumer’s acceptance. The aim of this work was to investigate the conservation of pea protein isolate (PPI) during time and especially the evolution of their organoleptic quality under two storage conditions. The evolution of the volatile compounds, the odor and the color of a PPI has been investigated during one year of storage. PPI was exposed to two treatments mimicking a lack of control of storage conditions: treatment A with light exposition at ambient temperature (A—Light 20 °C) and treatment B in the dark but with a higher temperature (B—Dark 30 °C). For each sampling time (0, 3, 6, 9, 12 months), the volatile compounds were determined using HS-SPME-GC-MS, the odor using direct sniffing, and the color using the measurement of L*, a*, b* parameters. Treatment A was the most deteriorating and led to a strong increase in the total volatile compounds amount, an odor deterioration, and a color change. Furthermore, a tentative correlation between instrumental data on volatile compounds and the perceived odor was proposed. By the representation of volatile compounds sorted by their sensory descriptor, it could be possible to predict an odor change with analytical data.
Potential Mechanisms Involved in the Protective Effect of Dicaffeoylquinic Acids from Artemisia annua L. Leaves against Diabetes and Its Complications
Authors: El-Askary Hesham , Salem Heba H. , Abdel Motaal Amira
Published: January 2022

Diabetes mellitus is a chronic disease affecting the globe and its incidence is increasing pandemically. The use of plant-derived natural products for diabetes management is of great interest. Polar fraction of Artemisia annua L. leaves has shown antidiabetic activity in vivo. In the present study, three major compounds were isolated from this polar fraction; namely, 3,5-dicaffeoylquinic acid (1); 4,5-dicaffeoylquinic acid (2), and 3,4- dicaffeoylquinic acid methyl ester (3), using VLC-RP-18 and HPLC techniques. The potential protective effects of these compounds against diabetes and its complications were investigated by employing various in vitro enzyme inhibition assays. Furthermore, their antioxidant and wound healing effectiveness were evaluated. Results declared that these dicaffeoylquinic acids greatly inhibited DPPIV enzyme while moderately inhibited α-glucosidase enzyme, where compounds 1 and 3 displayed the most prominent effects. In addition, compound 3 showed pronounced inhibition of α-amylase enzyme. Moreover, these compounds markedly inhibited aldose reductase enzyme and exerted powerful antioxidant effects, among which compound 3 exhibited the highest activity implying a notable potentiality in impeding diabetes complications. Interestingly, compounds 2 and 3 moderately accelerated scratch wound healing. Our findings suggest that these dicaffeoylquinic acids can be promising therapeutic agents for managing diabetes and its complications.
Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives
Authors: Mohammed Salih Osman , El Ashry Sayed H. El , Khalid Asaad , Amer Mohamed R. , Metwaly Ahmed M. , Eissa Ibrahim H. , Elkaeed Eslam B. , Elshobaky Ahmed , Hafez Elsayed E.
Published: January 2022

The urease enzyme has been an important target for the discovery of effective pharmacological and agricultural products. Thirteen regio-selectively alkylated benzimidazole-2-thione derivatives have been designed to carry the essential features of urease inhibitors. The urease enzyme was isolated from Helicobacter pylori as a recombinant urease utilizing the His-tag method. The isolated enzyme was purified and characterized using chromatographic and FPLC techniques showing a maximal activity of 200 mg/mL. Additionally, the commercial Jack bean urease was purchased and included in this study for comparative and mechanistic investigations. The designed compounds were synthesized and screened for their inhibitory activity against the two ureases. Compound 2 inhibited H. pylori and Jack bean ureases with IC50 values of 0.11; and 0.26 mM; respectively. While compound 5 showed IC50 values of 0.01; and 0.29 mM; respectively. Compounds 2 and 5 were docked against Helicobacter pylori urease (PDB ID: 1E9Y; resolution: 3.00 Å) and exhibited correct binding modes with free energy (ΔG) values of −9.74 and −13.82 kcal mol−1; respectively. Further; the in silico ADMET and toxicity properties of 2 and 5 indicated their general safeties and likeness to be used as drugs. Finally, the compounds’ safety was authenticated by an in vitro cytotoxicity assay against fibroblast cells.
Metastable Kitaev Magnets
Authors: Bahrami Faranak , Abramchuk Mykola , Lebedev Oleg , Tafti Fazel
Published: January 2022

Nearly two decades ago, Alexei Kitaev proposed a model for spin-1/2 particles with bond-directional interactions on a two-dimensional honeycomb lattice which had the potential to host a quantum spin-liquid ground state. This work initiated numerous investigations to design and synthesize materials that would physically realize the Kitaev Hamiltonian. The first generation of such materials, such as Na2IrO3, α-Li2IrO3, and α-RuCl3, revealed the presence of non-Kitaev interactions such as the Heisenberg and off-diagonal exchange. Both physical pressure and chemical doping were used to tune the relative strength of the Kitaev and competing interactions; however, little progress was made towards achieving a purely Kitaev system. Here, we review the recent breakthrough in modifying Kitaev magnets via topochemical methods that has led to the second generation of Kitaev materials. We show how structural modifications due to the topotactic exchange reactions can alter the magnetic interactions in favor of a quantum spin-liquid phase.
Preprocessing Strategies for Sparse Infrared Spectroscopy: A Case Study on Cartilage Diagnostics
Authors: Tafintseva Valeria , Lintvedt Tiril Aurora , Solheim Johanne Heitmann , Zimmermann Boris , Rehman Hafeez Ur , Virtanen Vesa , Shaikh Rubina , Nippolainen Ervin , Afara Isaac , Saarakkala Simo , Rieppo Lassi , Krebs Patrick , Fomina Polina , Mizaikoff Boris , Kohler Achim
Published: January 2022

The aim of the study was to optimize preprocessing of sparse infrared spectral data. The sparse data were obtained by reducing broadband Fourier transform infrared attenuated total reflectance spectra of bovine and human cartilage, as well as of simulated spectral data, comprising several thousand spectral variables into datasets comprising only seven spectral variables. Different preprocessing approaches were compared, including simple baseline correction and normalization procedures, and model-based preprocessing, such as multiplicative signal correction (MSC). The optimal preprocessing was selected based on the quality of classification models established by partial least squares discriminant analysis for discriminating healthy and damaged cartilage samples. The best results for the sparse data were obtained by preprocessing using a baseline offset correction at 1800 cm−1, followed by peak normalization at 850 cm−1 and preprocessing by MSC.
Biotransformation of (−)-α-Bisabolol by Absidia coerulea
Authors: Park Jisu , Han Fubo , Lee Ik-Soo
Published: January 2022

(−)-α-Bisabolol, a bioactive monocyclic sesquiterpene alcohol, has been used in pharmaceutical and cosmetic products with anti-inflammatory, antibacterial and skin-caring properties. However, the poor water solubility of (−)-α-bisabolol limits its pharmaceutical applications. It has been recognized that microbial transformation is a very useful approach to generate more polar metabolites. Fifteen microorganisms were screened for their ability to metabolize (−)-α-bisabolol in order to obtain its more polar derivatives, and the filamentous fungus Absidia coerulea was selected for scale-up fermentation. Seven new and four known metabolites were obtained from biotransformation of (−)-α-bisabolol (1), and all the metabolites exhibited higher aqueous solubility than that of the parent compound 1. The structures of newly formed metabolites were established as (1R,5R,7S)- and (1R,5S,7S)-5-hydroxy-α-bisabolol (2 and 3), (1R,5R,7S,10S)-5-hydroxybisabolol oxide B (4), (1R,7S,10S)-1-hydroxybisabolol oxide B (5), 12-hydroxy-α-bisabolol (7), (1S,3R,4S,7S)- and (1S,3S,4S,7S)-3,4-dihydroxy-α-bisabolol (8 and 10) on the basis of spectroscopic analyses. These compounds could also be used as reference standards for the detection and identification of the metabolic products of 1 in the mammalian system.
Potential Benefits of the Mediterranean Diet and Physical Activity in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study in a Spanish Population
Authors: Lorite-Fuentes Irene , Montero-Vilchez Trinidad , Arias-Santiago Salvador , Molina-Leyva Alejandro
Published: January 2022

There is scarce scientific information regarding the potential benefits of healthy lifestyles in patients with hidradenitis suppurativa (HS). The objective of this study is to explore the potential association between the adherence to a Mediterranean diet (MD), physical activity and HS severity. A cross-sectional study that included patients with HS was conducted. Disease severity was evaluated by the International Hidradenitis Suppurativa Severity Score System (IHS4) and self-reported disease activity using a Numeric Rating Scale (NRS, 0–10). The adherence to a MD was assessed by the PREvención con DIeta MEDiterránea (PREDIMED) questionnaire and the level of physical activity by the International Physical Activity questionnaire. A total of 221 patients with HS were included in our study. The adherence to a MD was average for a Spanish population. A higher adherence to a MD was associated with lower disease activity, lower self-reported Hurley and lower IHS4. The use of extra virgin olive oil as the main culinary lipid was the dietary habit that implied a lower degree of disease activity (p < 0.05). Regarding physical activity, both the self-reported severity and IHS4 presented an inverse association with the intensity of physical activity. The adherence to a MD and the intensity of physical activity were positively associated. The Mediterranean dietary pattern may have an impact on HS. Greater adherence to a MD is related to lower HS severity and more physical activity also correlates to lower disease severity. The MD could be an appropriate dietary pattern for patients with HS due to its anti-inflammatory properties, and combining this with increased levels of physical activity could have additional benefits.
Interaction between Lifestyle Changes and PNPLA3 Genotype in NAFLD Patients during the COVID-19 Lockdown
Authors: Cinque Felice , Cespiati Annalisa , Lombardi Rosa , Costantino Andrea , Maffi Gabriele , Alletto Francesca , Colavolpe Lucia , Francione Paolo , Oberti Giovanna , Fatta Erika , Bertelli Cristina , Sigon Giordano , Dongiovanni Paola , Vecchi Maurizio , Fargion Silvia , Fracanzani Anna Ludovica
Published: January 2022

The coronavirus disease 2019 (COVID-19) lockdown dramatically changed people’s lifestyles. Diet, physical activity, and the PNPLA3 gene are known risk factors for non-alcoholic fatty liver disease (NAFLD). Aim: To evaluate changes in metabolic and hepatic disease in NAFLD patients after the COVID-19 lockdown. Three hundred and fifty seven NAFLD patients were enrolled, all previously instructed to follow a Mediterranean diet (MD). Anthropometric, metabolic, and laboratory data were collected before the COVID-19 lockdown in Italy and 6 months apart, along with ultrasound (US) steatosis grading and information about adherence to MD and physical activity (PA). In 188 patients, PNPLA3 genotyping was performed. After the lockdown, 48% of patients gained weight, while 16% had a worsened steatosis grade. Weight gain was associated with poor adherence to MD (p = 0.005), reduced PA (p = 0.03), and increased prevalence of PNPLA3 GG (p = 0.04). At multivariate analysis (corrected for age, sex, MD, PA, and PNPLA3 GG), only PNPLA3 remained independently associated with weight gain (p = 0.04), which was also associated with worsened glycemia (p = 0.002) and transaminases (p = 0.02). During lockdown, due to a dramatic change in lifestyles, half of our cohort of NAFLD patients gained weight, with a worsening of metabolic and hepatologic features. Interestingly, the PNPLA3 GG genotype nullified the effect of lifestyle and emerged as an independent risk factor for weight gain, opening new perspectives in NAFLD patient care.
A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
Authors: Yan Sisi , Liu Sha , Qu Jianyu , Li Xiaowen , Hu Jiahao , Zhang Linyu , Liu Xiangyan , Li Xin , Wang Xianglin , Wen Lixin , Wang Ji
Published: January 2022

Dietary habit is highly related to nonalcoholic fatty liver disease (NAFLD). Low-fat–high-carbohydrate (LFHC) diets could induce lean NAFLD in Asians. Previously, we found that a lard and soybean oil mixture reduced fat accumulation with a medium-fat diet; therefore, in this study, we evaluated the effect of a lard and soybean oil mixture (LFHC diet) on NAFLD and its underlying mechanisms. Mice in groups were fed with lard, soybean oil, or a lard and soybean oil mixture—an LFHC diet—separately. Our results showed that mixed oil significantly inhibited serum triglyceride, liver triglyceride, serum free fatty acids (FFAs), and liver FFAs compared with soybean oil or lard, and we found fewer inflammatory cells in mice fed with mixed oil. RNA-seq results indicate that mixed oil reduced FFAs transportation into the liver via decreasing liver fatty acid-binding protein 2 expression, inhibited oxidative phosphorylation via tumor necrosis factor receptor superfamily member 6 downregulation, and alleviated inflammation via downregulating inflammatory cytokine. The liquid chromatography–mass spectrometry results showed that the mixed oil promoted bile acid conjugated with taurine and glycine, thus activating G-protein-coupled bile acid receptor 1 for improved lipids metabolism. In conclusion, the lard and soybean oil mixture alleviated NAFLD.
Association of Gastric Antrum Echodensity and Acute Gastrointestinal Injury in Critically Ill Patients
Authors: Wang Luping , Yang Hao , Lv Guangxuan , Fu Xin , Cheng Yisong , Zhong Xi , Yang Jing , Wang Bo , Zhang Zhongwei , Jin Xiaodong , Kang Yan , Wu Qin
Published: January 2022

(1) Background: Acute muscle inflammation leads to increased sonographic echodensity. We developed a technique to characterize the echodensity of the gastric antrum wall and assess its feasibility in evaluating the severity of acute gastrointestinal injury (AGI); (2) Methods: The B-mode images of the gastric antrum of each enrolled patient were obtained daily by point-of-care ultrasound (POCUS). The 50th percentile, 85th percentile, and mean value of the grayscale distribution according to histogram analysis (ED50, ED85, and EDmean, respectively) were used to characterize the gastric antrum echodensity. Consistency and correlation analyses were performed to evaluate the feasibility and reproducibility of gastric antrum echodensity measurement. The association of gastric antrum echodensity with the severity of AGI and its ability to predict feeding intolerance (FI) were analyzed; (3) Results: In total, 206 POCUS images of 43 patients were analyzed. The gastric antrum echodensity measurements had sufficient intra- and inter-investigator reliabilities (intraclass correlation coefficient >0.9 for all parameters). The ED50 showed a significant upward trend as AGI severity increased, as well as ED85 and EDmean (p for trend <0.001, respectively). Patients who experienced FI had a higher ED50 (67.8 vs. 56.1, p = 0.02), ED85 (85.6 vs. 71.2, p = 0.01), and EDmean (70.3 vs. 57.6, p = 0.01) upon enteral feeding initiation; (4) Conclusions: Measurement of gastric antrum echodensity was technically feasible and reproducible in ventilated patients. Increased gastric antrum echodensity was associated with greater severity of AGI. Patients with higher gastric antrum echodensity upon enteral nutrition initiation via a nasogastric tube were more likely to develop FI.
Acknowledgment to Reviewers of Optics in 2021
Authors:   Optics Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Enterotoxigenic Escherichia coli Heat-Stable Toxin and Ebola Virus Delta Peptide: Similarities and Differences
Authors: Melnik Lilia I. , Garry Robert F.
Published: January 2022

Enterotoxigenic Escherichia coli (ETEC) STb toxin exhibits striking structural similarity to Ebola virus (EBOV) delta peptide. Both ETEC and EBOV delta peptide are enterotoxins. Comparison of the structural and functional similarities and differences of these two toxins illuminates features that are important in induction of pathogenesis by a bacterial and viral pathogen.
Acknowledgment to Reviewers of Pediatric Reports in 2021
Authors:   Pediatric Reports Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Trend of Antihypertensive Medicine Use in the Baltic States between 2008 and 2018: A Retrospective Cross-National Comparison
Authors: Treciokiene Indre , Bratcikoviene Nomeda , Gulbinovic Jolanta , Wettermark Bjorn , Taxis Katja
Published: January 2022

High blood pressure is a major risk factor contributing to death and disability rates in the Baltic states. The aim of this study was to compare the utilization of antihypertensive medicines in Estonia, Latvia and Lithuania from 2008 to 2018. In this retrospective cross-national comparison, nationally representative wholesale data from the IQVIA National Retail Audit were analyzed. The utilization of inhibitors of the renin–angiotensin system, beta blockers, calcium channel blockers, diuretics and centrally acting antihypertensives by Defined Daily Doses per 1000 inhabitants and day (DDD/TID) was used to calculate utilization. Time series analysis was used to analyze trends. The utilization increased annually by 10.88, 8.04 and 6.42 DDD/TID in Estonia, Latvia and Lithuania, respectively, from 2008. The utilization of antihypertensive drugs in 2018 was 372, 267 and 379.5 DDD/TID, respectively. Inhibitors of the renin–angiotensin system were the most commonly used class in 2008 and 2018. From 2008, the utilization of beta blockers and fixed-dose combinations including renin–angiotensin system inhibitors increased substantially, while that of calcium channel blockers decreased. Country-specific utilization trends were noted; e.g., the utilization of centrally acting antihypertensives was 30.9 DDD/TID in Lithuania compared to 3.01 DDD/TID in Estonia and 16.17 DDD/TID in Latvia. The use of antihypertensive medicines increased over the study period, but the trends for the different drug classes differed between countries.
Acknowledgment to Reviewers of Pharmacy in 2021
Authors:   Pharmacy Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Clinical Update on Patient-Controlled Analgesia for Acute Postoperative Pain
Authors: Motamed Cyrus
Published: January 2022

Patient-controlled analgesia (PCA) is an effective method for controlling acute pain, including postoperative pain in adults and in children from five years of age, pain resulting from labor, trauma, or other medical situations, or chronic and malignant pain. The treatment consists of a mini-computer-controlled infusion pump permitting the administration of on-demand, continuous, or combined doses of analgesic (mainly opioid) variations in response to therapy, which allows pain to be significantly controlled. Intravenous (IV)-PCA minimizes individual pharmacodynamics and pharmacokinetic differences and is widely accepted as a reference method for mild or severe postoperative pain. IV-PCA is the most studied route of PCA; other delivery methods have been extensively reported in the literature. In addition, IV-PCA usually voids the gap between pain sensation and analgesic administration, permitting better recovery and fewer side effects. The most commonly observed complications are nausea and vomiting, pruritus, respiratory depression, sedation, confusion and urinary retention. However, human factors such as pharmacy preparation and device programming can also be involved in the occurrence of these complications, while device failure is much less of an issue.
Linearity and Optimum-Sampling in Photon-Counting Digital Holographic Microscopy
Authors: Demoli Nazif , Abramović Denis , Milat Ognjen , Stipčević Mario , Skenderović Hrvoje
Published: January 2022

In the image plane configurations frequently used in digital holographic microscopy (DHM) systems, interference patterns are captured by a photo-sensitive array detector located at the image plane of an input object. The object information in these patterns is localized and thus extremely sensitive to phase errors caused by nonlinear hologram recordings (grating profiles are either square or saturated sinusoidal) or inadequate sampling regarding the information coverage (undersampled around the Nyquist frequency or arbitrarily oversampled). Here, we propose a solution for both hologram recording problems through implementing a photon-counting detector (PCD) mounted on a motorized XY translation stage. In such a way, inherently linear (because of a wide dynamic range of PCD) and optimum sampled (due to adjustable steps) digital holograms in the image plane configuration are recorded. Optimum sampling is estimated based on numerical analysis. The validity of the proposed approach is confirmed experimentally.
Inhibition of Human Monoamine Oxidases A and B by Specialized Metabolites Present in Fresh Common Fruits and Vegetables
Authors: Marzo Claudio Marcello , Gambini Sofia , Poletti Stefania , Munari Francesca , Assfalg Michael , Guzzo Flavia
Published: January 2022

Diets rich in fruits and vegetables are associated with better psychological wellbeing and cognitive functions, although it is unclear which molecules and mechanisms are involved. One potential explanation is the inhibition of monoamine oxidases (MAOs), which have been linked to several neurological disorders. The present study investigated the ability of kiwifruit to inhibit MAO-A and MAO-B, refining an in vitro assay to avoid confounding effects. Ultra-performance liquid chromatography/mass spectrometry (UPLC-QTOF) and nuclear magnetic resonance spectroscopy (NMR) were used to select individual kiwifruit metabolites for further analysis. Moreover, extracts of other common fruits and vegetables were screened to identify promising candidate inhibitors. Multiple extracts and compounds inhibited both enzymes, and the selective inhibition of MAO-B by the major kiwifruit specialized metabolite D-(−)-quinic acid was observed. These results suggest that fruits and vegetables contain metabolites that inhibit the activity of MAO-A and -B, offering a potential natural option for the treatment of neurological disorders, in which MAOs are involved.
The INRAE Centre for Vegetable Germplasm: Geographically and Phenotypically Diverse Collections and Their Use in Genetics and Plant Breeding
Authors: Salinier Jérémy , Lefebvre Véronique , Besombes Didier , Burck Hélène , Causse Mathilde , Daunay Marie-Christine , Dogimont Catherine , Goussopoulos Juliette , Gros Christophe , Maisonneuve Brigitte , McLeod Louis , Tobal Fatiha , Stevens Rebecca
Published: January 2022

The French National Research Institute for Agriculture, Food and the Environment (INRAE) conserves and distributes five vegetable collections as seeds: the aubergine* (in this article the word aubergine refers to eggplant), pepper, tomato, melon and lettuce collections, together with their wild or cultivated relatives, are conserved in Avignon, France. Accessions from the collections have geographically diverse origins, are generally well-described and fixed for traits of agronomic or scientific interest and have available passport data. In addition to currently conserving over 10,000 accessions (between 900 and 3000 accessions per crop), the centre maintains scientific collections such as core collections and bi- or multi-parental populations, which have also been genotyped with SNP markers. Each collection has its own merits and highlights, which are discussed in this review: the aubergine collection is a rich source of crop wild relatives of Solanum; the pepper, melon and lettuce collections have been screened for resistance to plant pathogens, including viruses, fungi, oomycetes and insects; and the tomato collection has been at the heart of genome-wide association studies for fruit quality traits and environmental stress tolerance.
High-Performance Adhesive Joint Made from Densified Wood
Authors: Meethaworn Benjama , Srivaro Suthon , Khongtong Sureurg
Published: January 2022

The strength of an adhesive joint plays a major role in the implementation of engineering wood products; therefore, joint performance receives intense scrutiny. This study investigated a wooden adhesive joint, made from densified wood, the performance of which was dramatically enhanced. The wood sample was developed by performing mechanical compression and polymer impregnation on rubberwood. This treated rubberwood was additionally prepared by simple surface sanding prior to jointing. The highest wettability was found on surfaces sanded with the largest grit sandpaper. Consequently, glueline thickness increased with progressively larger grit (smaller grit number) sandpaper. In addition, the maximum shear strength for the joint made from the densified rubberwood was greater than that of that made from the original one, by 40%. Surprisingly, with the optimal sanding treatment, the shear strength of the wooden joint gradually increased with an increase in the density of the densified rubberwood from 1.05 to 1.30 g/cm3. Moreover, the rate of wood failure also increased throughout the stated density range.
Functional Compounds from Banana Peel Used to Decrease Oxidative Stress Effects
Authors: Avram Ionela , Gatea Florentina , Vamanu Emanuel
Published: January 2022

Banana peel, a little-used waste, contains a high amount of biologically active compounds. The aim of the study is to demonstrate in vitro, the antioxidant, cytotoxic, and antimicrobial effects of hydroalcoholic extracts from yellow (BP) and red (BPR) banana peels. The analysis of the extracts by Capillary Zone Electrophoresis (CZE) has confirmed the presence of several bioactive compounds. BPR has a higher in vitro antioxidant activity than BP, which correlates with a significant cytotoxic, antimicrobial effect, with a UVA/UVB rate of 0.9. In the case of BPR, the results confirm the presence of isoquercitrin and kaempferol in a 1:3 ratio. The bioactive compounds from the extracts have shown a different interaction with HCT-8 cell lines and with tested bacterial strains with pathogenic properties. The HCA analysis proved the biological value of BPR to reduce oxidative stress and its potential use in natural products.
Detailed Analysis of Exergy Destruction of All Basic Types of Heat Exchangers
Authors: Rauch Martina , Mudrinić Saša , Galović Antun
Published: January 2022

Dimensionless expressions of exergy destruction, normalized to ambient temperature and heat capacity of the weaker stream, for all basic types of recuperators are derived. The analytical expressions for maximum exergy destruction were calculated using the GNU Octave software for all recuperators, namely parallel-flow and counter-flow recuperators, and all forms of cross-flow heat exchangers, namely without mixing of streams, only mixing the streamlines of the weaker stream, only mixing the streamlines of the stronger stream and mixing the weaker and stronger streams. For parallel-flow and counter-flow recuperators, as well as for their special cases, expressions for local and total exergy destruction are given. It is shown that the maximum exergy destruction, as a local extreme, is the same for all recuperators for mutually equal values of the quantities π3 (ratio of the heat capacity of the weaker stream to the heat capacity of the stronger stream) and πT (ratio of the inlet temperature of the stronger stream to the inlet temperature of the weaker stream). The ratio of exergy destruction to effectiveness of each basic type of recuperator is further analyzed. The obtained results are presented and interpreted in appropriate dimensionless diagrams.
Damage Model and Experimental Study of a Sand Grouting-Reinforced Body under Seepage
Authors: Liu Linsheng , Wang Hongbo , Zheng Shijie , Dong Lianglin , Yu Yunchang , Yang Chunyu
Published: January 2022

Grouting is a reinforcing method commonly used in underground engineering. The grouting-reinforced body is in saturated groundwater, which is due to long-term seepage, resulting in reinforcing performance attenuation. This is a guarantee for the safe operation of the underground structure’s long life cycle that obtains the performance attenuation law of the grouting-reinforced body under the action of seepage. This paper uses primitive to describe the mechanical properties of grouting-reinforced body under seepage erosion, establishing the damage mechanics model of grouting-reinforced body under seepage, designing deterioration experimental of grouting-reinforced body under seepage, studying the mechanism of the permeation water pressure on the permeability of the grouting-reinforced body, and obtaining the variable of the grouting-reinforced body damage variable with the permeation water pressure. Studies have shown that seepage effects have a “sudden jump” phenomenon in the process of grouting-reinforced body erosion, and the limit damage of grouting-reinforced body is 0.15~0.19. The relationship between the permeability and damage variables of grouting-reinforced body under seepage are verified, and the quantitative relationship of grouting-reinforced body between permeation pressure, time and damage variables are obtained. This research is of great importance for improving the deterioration theory under seepage and ensuring the long-term safety of tunnel operations.
Defending Victims, Practicing Restraint: God-Consciousness and the Use of Force in the Qur’an
Authors: Ranieri John J.
Published: January 2022

The Qur’an speaks frequently of victims and the need to defend them—whether they are the marginalized, the oppressed, those who bring God’s word to a resistant people, or the early community of believers. However, the obligation to defend victims leads to the question of whether force can be used in their defense (including self-defense). Too often, this question is addressed by isolating passages that allow for the use of force, trying to identify their occasions of revelation, and considering whether later passages abrogate earlier ones. This approach suggests that the use of force or violence is an identifiable theme in the Qur’an, detachable from its broader message. However, the question of how and when force may be used is inseparable from the important Qur’anic notion of God-consciousness (taqwa), which ifs presupposed in the Qur’an when considering whether the use of force is justified. God-consciousness serves both as a source of restraint for those who would resort to violence out of anger or indignation, as well as a critical standard for those who find themselves conflicted over the possible use of force. Considering the question of the use of force in the defense of victims in light of God-consciousness shifts the focus away from isolated passages and arguments about abrogation to a more open and adaptable approach that calls into question the use of force as one option among others, and leaves open up the possibility of a non-violent response as entirely keeping with the spirit of the Qur’an.
Acknowledgment to Reviewers of Reports in 2021
Authors:   Reports Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Ground Deformation Pattern Analysis and Evolution Prediction of Shanghai Pudong International Airport Based on PSI Long Time Series Observations
Authors: Bao Xin , Zhang Rui , Shama Age , Li Song , Xie Lingxiao , Lv Jichao , Fu Yin , Wu Renzhe , Liu Guoxiang
Published: January 2022

Being built on the reclamation area, Shanghai Pudong International Airport (SPIA) has been undergoing uneven subsidence since the beginning of its operation in 1999. In order to explore the evolution characteristics of ground deformation in the SPIA reclamation area and further provide assurance for the airport’s safe operation, 141 Sentinel-1A images from October 2016 to September 2021 were selected to acquire time-series ground deformation observations by the StaMPS PSI processing procedure. We subsequently built a ground deformation prediction model using the Long Short Term Memory (LSTM) neural network for the short-term prediction of the SPIA deformation severity area. On this basis, the spatial-temporal evolution trends of SPIA ground deformation in the reclamation area were revealed concerning the influence and mode of action of geological conditions and environmental factors. Finally, we proposed targeted recommendations and strategies for the comprehensive ground deformation prevention and control needs of SPIA. The results indicated that the SPIA exhibits overall subsidence in the eastern part, with the maximum deformation rate reaching −57.29 mm/a. Meanwhile, the central and western part has a local uplift with the maximum deformation rate reaching 32.76 mm/a. The proposed LSTM ground deformation prediction model demonstrated excellent robustness in the region of uneven deformation, and the prediction results were in high agreement with the StaMPS PSI monitoring results. The time-series observations and prediction results are expected to provide references for the expansion project of SPIA and help the research of ground deformation and prevention in related fields.
Phase Mismatch Calibration for Dual-Channel Sliding Spotlight SAR-GMTI
Authors: Zhang Zhenning , Yu Weidong , Zheng Mingjie , Zhao Liangbo , Zhou Zi-Xuan
Published: January 2022

This article investigates channel phase mismatch calibration during the application of displaced-phase-center antenna (DPCA) in dual-channel sliding spotlight synthetic aperture radar (SAR) for ground moving target indication (GMTI). In sliding spotlight SAR, the utilization of beam progressive sweeping in azimuth causes antenna phase centers to be misaligned from the sensor path, resulting in the phase mismatch between channels. Then, spatial channel co-registration required in the DPCA cannot be achieved directly by an azimuth time shift. In this study, a calibration method based on scanning geometry of the dual-channel sliding spotlight SAR is developed to address this issue. Moreover, the effect of the phase mismatch calibration on the estimation of azimuth time difference between the two channels is derived and analyzed in depth. The clutter suppression results processed from experimental data acquired by a C-band dual-channel SAR system (Gaofen-3) operated in sliding spotlight mode are shown for the first time to demonstrate the effective phase mismatch calibration.