bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Range Compression Algorithm for Resolution Enhancement in GNSS-SARs
Authors: Zheng Yu , Yang Yang , Chen Wu
Published: June 2017

In this paper, a novel range compression algorithm for enhancing range resolutions of a passive Global Navigation Satellite System-based Synthetic Aperture Radar (GNSS-SAR) is proposed. In the proposed algorithm, within each azimuth bin, firstly range compression is carried out by correlating a reflected GNSS intermediate frequency (IF) signal with a synchronized direct GNSS base-band signal in the range domain. Thereafter, spectrum equalization is applied to the compressed results for suppressing side lobes to obtain a final range-compressed signal. Both theoretical analysis and simulation results have demonstrated that significant range resolution improvement in GNSS-SAR images can be achieved by the proposed range compression algorithm, compared to the conventional range compression algorithm.
Statistical Analysis of the Main Configuration Parameters of the Network Dynamic and Adaptive Radio Protocol (DARP)
Authors: Estevez Francisco , González Jesús , Glösekötter Peter , Valenzuela Olga , Rojas Ignacio
Published: June 2017

The present work analyses the wireless sensor network protocol (DARP) and the impact of different configuration parameter sets on its performance. Different scenarios have been considered, in order to gain a better understanding of the influence of the configuration on network protocols. The developed statistical analysis is based on the method known as Analysis of Variance (ANOVA), which focuses on the effect of the configuration on the performance of DARP. Three main dependent variables were considered: number of control messages sent during the set-up time, energy consumption and convergence time. A total of 20,413 simulations were carried out to ensure greater robustness in the statistical conclusions. The main goal of this work is to discover the most critical configuration parameters for the protocol, with a view to potential applications in Smart City type scenarios.
An Investigation of the Mechanics and Sticking Region of a One-Repetition Maximum Close-Grip Bench Press versus the Traditional Bench Press
Authors: Lockie Robert , Callaghan Samuel , Moreno Matthew , Risso Fabrice , Liu Tricia , Stage Alyssa , Birmingham-Babauta Samantha , Stokes John , Giuliano Dominic , Lazar Adrina , Davis DeShaun , Orjalo Ashley
Published: June 2017

The close-grip bench press (CGBP) is a variation of the traditional bench press (TBP) that uses a narrower grip (~95% of biacromial distance (BAD)) and has potential application for athletes performing explosive arm actions from positions where the hands are held close to the torso. Limited research has investigated CGBP mechanics compared to the TBP. Twenty-seven resistance-trained individuals completed a one-repetition maximum TBP and CGBP. The TBP was performed with the preferred grip; the CGBP with a grip width of 95% BAD. A linear position transducer measured lift distance and duration; peak and mean power, velocity, and force; distance and time when peak power occurred; and work. Pre-sticking region (PrSR), sticking region, and post-sticking region distance and duration for each lift was measured. A repeated measures ANOVA was used to derive differences between TBP and CGBP mechanics (p < 0.01); effect sizes (d) were also calculated. A greater load was lifted in the TBP, thus mean force was greater (d = 0.16–0.17). Peak power and velocity were higher in the CGBP, which had a longer PrSR distance (d = 0.49–1.32). The CGBP could emphasize power for athletes that initiate explosive upper-body actions with the hands positioned close to the torso.
Manager’s Dilemma: Stockholders’ and Consumers’ Responses to Corporate Environmental Efforts
Authors: Yadav Prayag , Han Seung , Kim Hohyun
Published: June 2017

This study aims to reveal that different stakeholders have different environmental preferences by demonstrating the managers’ dilemma of selecting an appropriate environmental strategy to achieve firms’ corporate goals. It analyzes the effects of firms’ efforts in environmental impact through actual environmental practices and environmental considerations in environmental management on stockholders’ and consumers’ responses by using the Newsweek Green Rankings 2012 for large US-based firms. The study uses the event study methodology and the ordinary least squares multivariate regression model conditioned with relevant firm and industry-specific characteristics. The results indicate that both stockholders and consumers appreciate corporate efforts in reducing environmental damage; however, consumers exhibit a significant and negative response against firms’ environmental management efforts. The conflicting results provide valuable insights into the alignment of environmental efforts for developing core competencies that lead firms toward sustainability. Further, this research makes a valuable contribution to the existing literature and provides guidelines for the formulation of public policies that encourage corporate environmental efforts to ensure simultaneous development of business and society.
How the Social-Ecological Systems Concept Can Guide Transdisciplinary Research and Implementation: Addressing Water Challenges in Central Northern Namibia
Authors: Liehr Stefan , Röhrig Julia , Mehring Marion , Kluge Thomas
Published: June 2017

Research aimed at contributing to the further development of integrated water resources management needs to tackle complex challenges at the interface of nature and society. A case study in the Cuvelai-Etosha Basin in Namibia has shown how semi-arid conditions coinciding with high population density and urbanisation present a risk to people’s livelihoods and ecosystem health. In order to increase water security and promote sustainable water management, there is a requirement for problem-oriented research approaches combined with a new way of thinking about water in order to generate evidence-based, adapted solutions. Transdisciplinary research in particular addresses this issue by focusing on the problems that arise when society interacts with nature. This article presents the implementation of a transdisciplinary research approach in the above-mentioned case study. The concept of social-ecological systems (SES) plays a key role in operationalising the transdisciplinary research process. Application of the SES concept helps to outline the problem by defining the epistemic object, as well as structure the research process itself in terms of formulating research questions and developing the research design. It is argued here that the SES concept is not merely useful, but also necessary for guiding transdisciplinary sustainability research and implementation. The study from Namibia clearly demonstrates that the introduction of technological innovations such as rainwater and floodwater harvesting plants requires a social-ecological perspective. In particular this means considering questions around knowledge, practices and institutions related to water resources management and includes various societal innovations alongside technologies on the agenda.
HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B
Authors: Collin Vanessa , Flamand Louis
Published: June 2017

Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of descendants. Such individuals, carrying one copy of the HHV-6A/B genome in every cell, are referred to as having inherited chromosomally-integrated HHV-6A/B (iciHHV-6) and represent approximately 1% of the world’s population. Interestingly, HHV-6A/B integrate their genomes in a specific region of the chromosomes known as telomeres. Telomeres are located at chromosomes’ ends and play essential roles in chromosomal stability and the long-term proliferative potential of cells. Considering that the integrated HHV-6A/B genome is mostly intact without any gross rearrangements or deletions, integration is likely used for viral maintenance into host cells. Knowing the roles played by telomeres in cellular homeostasis, viral integration in such structure is not likely to be without consequences. At present, the mechanisms and factors involved in HHV-6A/B integration remain poorly defined. In this review, we detail the potential biological and medical impacts of HHV-6A/B integration as well as the possible chromosomal integration and viral excision processes.
Water Temperature Ensemble Forecasts: Implementation Using the CEQUEAU Model on Two Contrasted River Systems
Authors: Ouellet-Proulx Sébastien , St-Hilaire André , Boucher Marie-Amélie
Published: June 2017

In some hydrological systems, mitigation strategies are applied based on short-range water temperature forecasts to reduce stress caused to aquatic organisms. While various uncertainty sources are known to affect thermal modeling, their impact on water temperature forecasts remain poorly understood. The objective of this paper is to characterize uncertainty induced to water temperature forecasts by meteorological inputs in two hydrological contexts. Daily ensemble water temperature forecasts were produced using the CEQUEAU model for the Nechako (regulated) and Southwest Miramichi (natural) Rivers for 1–5-day horizons. The results demonstrate that a larger uncertainty is propagated to the thermal forecast in the unregulated river (0.92–3.14 °C) than on the regulated river (0.73–2.29 °C). Better performances were observed on the Nechako with a mean continuous ranked probability score (MCRPS) <0.85 °C for all horizons compared to the Southwest Miramichi (MCRPS ≈ 1 °C). While informing the end-user on future thermal conditions, the ensemble forecasts provide an assessment of the associated uncertainty and offer an additional tool to river managers for decision-making.
MicroRNA-138 Inhibits Cell Growth, Invasion, and EMT of Non-Small Cell Lung Cancer via SOX4/p53 Feedback Loop
Authors: Li Dandan , He Changjun , Wang Junfeng , Wang Yanbo , Bu Jianlong , Kong Xianglong , Sun Dawei
Published: June 2017

Many studies have shown that downregulation of miR-138 occurs in a variety of cancers including non-small cell lung cancer (NSCLC). However, the precise mechanisms of miR-138 in NSCLC have not been well clarified. In this study, we investigated the biological functions and molecular
mechanisms of miR-138 in NSCLC cell lines, discussing whether it could turn out to be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is downregulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression
of SOX4 in NSCLC tissues and cell lines. Upregulation of miR-138 significantly inhibited proliferation of NSCLC cells. In addition, invasion and EMT of NSCLC cells were suppressed by overexpression of miR-138. However, downregulation of miR-138 promoted cell growth and metastasis of NSCLC
cells. Bioinformatics analysis predicted that SOX4 was a potential target gene of miR-138. Next, luciferase reporter assay confirmed that miR-138 could directly target SOX4. Consistent with the effect of miR-138, downregulation of SOX4 by siRNA inhibited proliferation, invasion, and EMT of
NSCLC cells. Overexpression of SOX4 in NSCLC cells partially reversed the effect of miR-138 mimic. In addition, decreased SOX4 expression could increase the level of miR-138 via upregulation of p53. Introduction of miR-138 dramatically inhibited growth, invasion, and EMT of NSCLC cells through
a SOX4/p53 feedback loop.
miR-205 Inhibits Neuroblastoma Growth by Targeting cAMP-Responsive Element-Binding Protein 1
Authors: Chen Shu , Jin Lianhua , Nie Shu , Han Lizhi , Lu Na , Zhou Yan
Published: June 2017

Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development, and metastasis in various cancers. However, its functions in neuroblastoma (NB) remain largely unclear. Here we found that miR-205 was significantly downregulated in human NB tissue
samples and cell lines. miR-205 expression was lower in poorly differentiated NB tissues and those of advanced International Neuroblastoma Staging System stage. In addition, restoration of miR-205 in NB cells suppressed proliferation, migration, and invasion and induced cell apoptosis in vitro,
as well as impaired tumor growth in vivo. cAMP-responsive element-binding protein 1 (CREB1) was identified as a direct target gene of miR-205. Expression of an miR-205 mimic in NB cells significantly diminished expression of CREB1 and the CREB1 targets BCL-2 and MMP9. CREB1 was also
found to be upregulated in human NB tissues, its expression being inversely correlated with miR-205 expression (r=0.554, p=0.003). Importantly, CREB1 upregulation partially rescued the inhibitory effects of miR-205 on NB cells. These findings suggest that miR-205 may function
as a tumor suppressor in NB by targeting CREB1.
Determining Empirical Stellar Masses and Radii from Transits and Gaia Parallaxes as Illustrated by Spitzer Observations of KELT-11b
Authors: Beatty Thomas G. , Stevens Daniel J. , Collins Karen A. , Colón Knicole D. , James David J. , Kreidberg Laura , Pepper Joshua , Rodriguez Joseph E. , Siverd Robert J. , Stassun Keivan G. , Kielkopf John F.
Published: June 2017

Using the Spitzer Space Telescope, we observed a transit at 3.6 μm of KELT-11b. We also observed three partial planetary transits from the ground. We simultaneously fit these observations, ground-based photometry from Pepper et al., radial velocity data from Pepper et al., and a spectral energy distribution (SED) model using catalog magnitudes and the Hipparcos parallax to the system. The only significant difference between our results and those of Pepper et al. is that we find the orbital period to be shorter by 37 s, 4.73610 ± 0.00003 versus 4.73653 ± 0.00006 days, and we measure a transit center time of

2457483.4310 ± 0.0007, which is 42 minutes earlier than predicted. Using our new photometry, we precisely measure the density of the star KELT-11 to 4%. By combining the parallax and catalog magnitudes of the system, we are able to measure the radius of KELT-11b essentially empirically. Coupled with the stellar density, this gives a parallactic mass and radius of 1.8

and 2.9

, which are each approximately 1σ higher than the adopted model-estimated mass and radius. If we conduct the same fit using the expected parallax uncertainty from the final Gaia data release, this difference increases to 4σ. The differences between the model and parallactic masses and radii for KELT-11 demonstrate the role that precise Gaia parallaxes, coupled with simultaneous photometric, radial velocity, and SED fitting, can play in determining stellar and planetary parameters. With high-precision photometry of transiting planets and high-precision Gaia parallaxes, the parallactic mass and radius uncertainties of stars become 1% and 3%, respectively. TESS is expected to discover 60–80 systems where these measurements will be possible. These parallactic mass and radius measurements have uncertainties small enough that they may provide observational input into the stellar models themselves.
ALMA Observations of the Young Substellar Binary System 2M1207
Authors: Ricci L. , Cazzoletti P. , Czekala I. , Andrews S. M. , Wilner D. , Szűcs L. , Lodato G. , Testi L. , Pascucci I. , Mohanty S. , Apai D. , Carpenter J. M. , Bowler B. P.
Published: June 2017

We present ALMA observations of the 2M1207 system, a young binary made of a brown dwarf with a planetary-mass companion at a projected separation of about 40 au. We detect emission from dust continuum at 0.89 mm and from the

rotational transition of CO from a very compact disk around the young brown dwarf. The small radius found for this brown dwarf disk may be due to truncation from the tidal interaction with the planetary-mass companion. Under the assumption of optically thin dust emission, we estimate a dust mass of 0.1 M
⊕ for the 2M1207A disk and a 3σ upper limit of ∼1 M
Moon for dust surrounding 2M1207b, which is the tightest upper limit obtained so far for the mass of dust particles surrounding a young planetary-mass companion. We discuss the impact of this and other non-detections of young planetary-mass companions for models of planet formation that predict circumplanetary material to surround these objects.
A comparative study of truncation in Malay and Indonesian
Authors: Raihan Syed Jaafar Sharifah
Published: June 2017

Il a longtemps été considéré, dans des études antérieures, que le malais et l’indonésien étaient des langues dissyllabiques, c’est-à-dire que les mots, dans chacune de ces langues, devaient comporter au moins deux syllabes. Cet article a pour objectif de montrer qu’en réalité il existe, dans l’un et l’autre cas, des éléments qui ne respectent pas cette exigence. Pour ce faire, on se centrera sur la troncature des noms de personnes et des termes d’adresse en malais et en indonésien. Cette étude illustre le fait que le principe de minimalité des langues est violé par les troncatures monosyllabiques, l’un des modèles de troncature, ainsi que par les troncatures disyllabiques. Si l’on tient compte du modèle Morpheme - Base (MBT) , les troncatures dans les deux langues doivent satisfaire la contrainte appelée BASE ≠ TRUNC , laquelle exige que les formes tronquées ne soient pas identiques à la forme de base . Il en résulte que les troncatures monosyllabiques émergent, en particulier, lorsque les bases sont disyllabiques, cette contrainte occupant un rang élevé dans le classement des contraintes portant sur ces deux langues.
La politique culturelle polonaise en Suisse : acteurs et liaisons informelles autour de la figure d’Henryk Opieński
Authors: Duber Paweł
Published: June 2017

La diplomatie culturelle polonaise use principalement de relations informelles. Ainsi, Henryk Opieński, pianiste et compositeur, résidant permanent en Suisse, entretient-il des contacts étroits avec des diplomates polonais résidant à Berne et à Genève après l’accession à l’indépendance de son pays natal. Nombreux sont les projets culturels rendus possibles grâce à sa contribution en tant qu’initiateur et exécutant. Son activité dévoilée par son abondante correspondance exemplifie les mécanismes de la diplomatie culturelle et permet d’ébaucher un « modèle » élaboré durant l’entre-deux-guerres et la Seconde Guerre mondiale. Constamment sous-financée, celle-ci s’est appuyée tout d’abord sur des organisations patriotiques liées à l’émigration et quelques individus comme Opieński. On note également un manque de réflexions approfondies au ministère des Affaires étrangères sur des projets d’envergure visant des objectifs à long terme. Souligner l’importance des contacts informels entre le monde diplomatique et artistique, c’est également éclairer, à l’arrière-plan, le rôle d’acteurs importants.
« Nous devons élargir chaque fissure du rideau de fer. » La diplomatie culturelle américaine en direction du bloc soviétique au prisme des échanges universitaires (1955-1961)
Authors: Faure Justine
Published: June 2017

Cet article se propose de revenir sur les années fondatrices de la diplomatie culturelle des États-Unis en direction du bloc soviétique à travers l’étude d’une organisation méconnue, l’Inter-University Committee for Travels Grants (IUCTG). Fondée par des universitaires en 1955 afin de gérer les échanges en sciences humaines et sociales avec l’URSS, cette organisation offre un exemple intéressant du fonctionnement des réseaux privé-public en temps de Guerre froide. À travers cette étude de cas, l’article apporte un autre regard sur la chronologie, révélant en particulier l’opposition initiale du Département d’État aux échanges de personnes entre les États-Unis et l’URSS et, en conséquence, le rôle pionnier du secteur privé dans ce domaine. Il éclaire aussi les convergences et divergences entre l’État et les universitaires, notamment sur la finalité des échanges.
Diplomaties culturelles occidentales en conjoncture de détente. Le lancement d’un programme d’échanges académiques Est-Ouest à la 6 e  Section de l’EPHE
Authors: Popa Ioana
Published: June 2017

L’article examine l’action conjointe d’acteurs publics et privés ayant œuvré dans différents espaces nationaux occidentaux en faveur d’échanges académiques Est-Ouest au moment du dégel. Il vise à encastrer la politique d’internationalisation scientifique d’une institution académique précise dans des diplomaties culturelles occidentales définies à des échelles plus amples qui à la fois lui offrent des moyens d’action et la soumettent à des contraintes. Concrètement, l’article analyse les conditions de lancement à la 6 e  Section de l’École Pratique des Hautes Études d’un programme d’échanges académiques en direction d’Europe de l’Est au milieu des années 1950. Il situe cette initiative à la jonction des politiques culturelles extérieures déployées par l’État français et par une fondation philanthropique américaine, la Fondation Ford, et interroge ses connexions avec la diplomatie publique des États-Unis. Cette étude de cas permet d’observer la (re)définition des stratégies occidentales de Guerre froide intellectuelle et les conditions de la mise en place de différents circuits d’internationalisation scientifique Est-Ouest lors de la détente.
Un modèle finlandais ? Administrer et coordonner les diplomaties publiques et culturelles, 1944-1975
Authors: Clerc Louis
Published: June 2017

L’image des petits États à l’étranger est une donnée géopolitique, commerciale et identitaire essentielle, qui appelle de leur part un travail de communication mené avec des ressources et dans des buts bien définis. Par souci d’utilisation efficace de leurs ressources ou par suivisme à l’égard de paradigmes transnationaux, ces petits États peuvent être tentés d’adopter certains modèles étrangers. Comment s’opère alors la relation entre modèles extérieurs et réalités internes ? Cet article considère la question à travers l’exemple de la Finlande durant la Guerre froide. Nous verrons que, si les inspirations extérieures sont évidentes, le contexte national finlandais résiste à l’adoption de modèles organisationnels extérieurs.
Towards an Intelligent Hybrid Recommendation System for E-Learning Platforms Using Data Mining
Authors: El Mabrouk Marouane , Gaou Salma , Rtili Mohamed Kamal
Published: June 2017

Nowadays, Information and communications technology (ICT) becomes a very important thing in human life in different fields. They are used in many fields as information systems (software, middleware) using various telecommunication media to give users the ability to manipulate digital data. In addition, with new technology development, a new concept appeared in the late 90s and early millennium, which is distance learning through e-Learning platform. Recommendation systems become increasingly used in information systems and especially in e-learning platform. These systems are used to propose and recommend content of these platforms to users according to needs of the latter in order to allow them to have the maximum information for learning.
In this paper, we present an intelligent hybrid recommendation system based on data mining. This system has four parts, the first for data collection and for center of interest construction by two modes: explicit data collection, which based on users and what they filled in their profiles, and implicit and automatic data collection by proposing a survey to users in order to gather information about their interest. A second part for processing information already collected in the previous part and for creating the learning model, classifying users who posted the content and classifying content also in order to send the results to the recommendation module. The third part is for making the similarity between learners and content and doing the recommendation for learners and the final part is for creating a log file of recommendation by learner, which will be used in the upcoming recommendation. According to results already done, we noticed that our proposition is satisfactory and the system is well optimized in terms of accuracy, response and processing time compared to the standard recommendation.
An Efficient Extreme Learning Machine Based on Fuzzy Information Granulation
Authors: Gao Yuehua , Chen Tianyi
Published: June 2017

In order to improve learning efficiency and generalization ability of extreme learning machine (ELM), an efficient extreme learning machine based on fuzzy information granulation (FIG) is put forward. The new approach not only improves the speed of basic ELM algorithm that contains many hidden nodes, but also overcomes the weakness of basic ELM of low learning efficiency and generalization ability by getting rid of redundant information in the observed values. The experimental results show that the proposed method is effective and can produce desirable generalization performance in most cases based on a few regression and classification problem.
Analysis on the Co-authoring in the Field of Management in China: Based on Social Network Analysis
Authors: Wang Chuanyi , Cheng Zhe , Huang Zhiwei
Published: June 2017

Using bibliographic data extracted from CNKI database, social network analysis is used to generate and analyze the network of co-authors of China in the field of management. This article suggests that: the density of the network is low, which means the collaboration between authors in China is not tight; the relations between the degree centrality and research output are weak. The author who published more papers may not have more co-authors. Through the lens of betweenness centrality, several authors in key positions of network are always dominating the academic information exchange and the small groups of authors have changed from 2006 to 2015. The result of core-periphery analysis reflects that only a very small proportion of scholars are in the core of the network while most are relatively independent. The similarity of working experience, academic authority and geographical closeness are helpful to form and enhance the collaboration network.
How ICT-Enabled Systems Can Enhance Opportunities of Education for Persons with Disabilities
Authors: Martinho Maria , Sangokoya David Adeoluwa , Martinez Carson , Pestre Gabriel
Published: June 2017

The chapter provides an overview of the use of ICT tools to enhance education for persons with disabilities in developing countries. The chapter per the authors begins by presenting the international legislation on education and ICT access for persons with disabilities, and then provides both a typology for ICT usage in education for persons with disabilities as well as case studies. The authors then discuss how digital information derived from usage of ICT tools can be used to inform inclusive educational policies and programs. Finally, the chapter describes current challenges and opportunities, and provides recommendations for scaling up ICT in developing countries as a mean to improve education for persons with disabilities.
KHETI
Authors: Rizvi Syed Mohammad Haider , Dearden Andy
Published: June 2017

The advancements in Information and Communication Technologies (ICTs) and their applications in development arenas have tremendously boosted prospects of human development. In education and agriculture domains ICTs have been applied and paid dividends. In this paper, an innovative and participatory designed ICT solution – ‘Knowledge Help Extension Technology Initiative (KHETI)' that is meant to ensure flow of agriculture information in real time to poor farmers at remote locations has been discussed. KHETI has leveraged upon the power of ICTs, particularly the multi-media mobiles phones to boost the extension services. It has features to construct, record, play and sending Short Dialogue Strips. The system and its functionalities are speeding-up communications through images and voices amongst various stakeholders and Agriculture Specialist with help of mobiles to get back responses on their queries, problems and other areas of interest. The paper has dealt in detail about KHETI and its possible extension in open and distance learning services for facilitating access to education facilities.
Paradigm Shift in Teacher Training With the Intervention of Open and Distance Learning Programmes
Authors: Dimri Anil K.
Published: June 2017

In the present chapter an attempt has been made to discuss the teacher's education and training offered through Distance mode of learning and the response of the teachers to these programmes. Efforts of various committees and commissions to strengthen teacher education are also presented. IGNOU offers variety of programmes through ODL pertaining to teacher education, at different level which are offered based on the principle of networking, resource sharing and convergence. Attempt has also been made to analyse learners interest in different programmes offered through ODL by IGNOU during last three academic years and it has been noticed that there was overwhelming response of the learners for majority of the programmes. The chapter also suggests indicative interventions which need to be addressed carefully in the changing scenario particularly with the shift towards Open Education Resource (OER) and Massive Open Online Course (MOOC) with unlimited participation and open access through web which provide interactive user forums to support community interactions among stake holders.
OER and Management Education in India
Authors: Agrawal Neeti
Published: June 2017

This chapter discusses the strategic perspective of OER in Management Education specifically in India. The study is exploratory and descriptive in nature and is based more on the secondary data. The primary data is in the form of informal feedback from the faculty and academic associates of Business Management in the State Open Universities having Management Departments/Schools in India. The primary data has been gathered using awareness, use, innovation methods and content delivery as the basic parameters for the purpose of study. The data was collected using informal questionnaire. The findings of the study show that there is limited awareness regarding the concept and theory of OER and therefore the use of the resource are not as expected. The study is limited to the Distance Learning Universities and the conventional Universities offering distance education have been omitted.
Role of Open Universities for Community-Based Developmental Interventions
Authors: Guha Ananya S.
Published: June 2017

The mindboggling growth of Information and Communication Technologies (ICT) has opened up exciting new possibilities to enhance the reach of developmental interventions in resource starved regions. Indian conditions are most challenging primarily due to diverse socioeconomic and cultural variations which present a major developmental challenge. Of late there has been widespread sensitization in policy making level for use of technological interventions to mitigate the developmental challenges. However the receptivity of such technological interventions depends on the peculiar characteristics of such disadvantaged communities. This chapter describes an important developmental intervention named as Community Information Centers carried out by an open university in India where author has been working at the helm of affairs. The chapter described the overall rationale for involving community, narrates the learning experiences and proposes a model for future such interventions. The experiences can be useful for replication of similar initiatives in other parts of the developing world. It can also evolve a new perspective for implementing India's ambitious University Outreach Programme called “Unnat Bharat Abhiyaan.”
Students with Learning Disabilities' Perceptions of Self-Determining Factors Contributing to College Success
Authors: Wegner Theresa Marie
Published: June 2017

This qualitative study identified the factors that contributed to the success experienced by students with learning disabilities in their first year of college. The primary factors that emerged from student interviews were their attitudes about higher education, and their personal attributes including motivation, maturity, and persistence. Additionally, students' adjustment to academic and campus life, and their use of supports and skills, such as college tutors, studying, managing time, and advocating for their needs were factors that led them to college persistence. Practical implications are proposed for secondary educators, postsecondary support staff and educators, students, and families.
Towards a Conceptual Framework for Investigating Information Systems Success
Authors: Hussein Safaa
Published: June 2017

Information Systems are widely used in the banking sector, as banks are information intensive. The investment in ISs by banking organizations will continue to increase for two reasons; everyone is using some kind of information systems in their day-to-day activities. Banking organizations cannot afford to be left behind technologically, since many customers are using these systems to manage their money, accounts and savings information. As the field of IS grows, the BIS literature did not mature to meet the needs of practice. One particular area that is in need for further exploration is the evaluation of IS currently in the banking sector. This paper develops a conceptual framework to examine the success of IS in the Egyptian BI. This adds value to the body of knowledge by investigating Information Systems Success. Depending on this investigation, researchers and scholars in the field of Information Systems can have a clear view to set their attitudes towards suitable future research studies which in turn contributes to the related accumulated knowledge in the field.
An Adaptive Enterprise Architecture Framework and Implementation
Authors: Masuda Yoshimasa , Shirasaka Seiko , Yamamoto Shuichiro , Hardjono Thomas
Published: June 2017

Considering the relation between Enterprise Architecture (EA) and IT is a prerequisite when promoting the uptake of IT by societies. In this paper, the authors propose an “Adaptive Integrated EA framework,” based on the results of a survey, to support the strategy of promoting cloud/mobile IT. They considered a unique advanced case and provide details and the structure/mechanism of building this EA framework in a global pharmaceutical company. Moreover, the authors revealed the effectiveness of the proposed EA framework by evaluating/analyzing the problems caused by the rapid shift to cloud/mobile IT in divisions in the US and Europe. Furthermore, they compared the characteristics of The Open Group Architecture Framework (TOGAF) and the “Adaptive Integrated EA framework” (global deployment) in building EA frameworks while evaluating the effectiveness of this framework to achieve digital transformation. Finally, the authors clarify the challenges, benefits, and critical success factors of the framework to assist EA practitioners with its implementation.
Lessons Learned from Enterprise Resource Planning (ERP) Implementations in an Australian Company
Authors: Chugh Ritesh , Sharma Subhash C. , Cabrera Andrés
Published: June 2017

Successful Enterprise Resource Planning (ERP) implementations are a boon for organisations. However, there have been many instances of failed ERP implementations globally resulting in millions of wasted dollars. It is vital to learn from past ERP implementations so that such expensive mistakes are not recurrent. This qualitative exploratory case study aims to explore and document the lessons learned from ERP implementations in an Australian global natural resources company to mitigate such problems in the future. A single case study was conducted with the aim to understand experiences from different sites of the company that have already undergone proprietary ERP system implementation. Data was collected through interviews of key participants who were involved in the implementation. Analysis of the interviews has resulted in comprehensive lessons learned around the project focus areas. Finally, ten tips, divided in 4 categories i.e. People, Strategy, Technology and Management have been identified, to guide future ERP implementations and increase chances of success.
A Multi-Criteria Strategic Decision Making Model to Assess Renewable Energy Forms
Authors: Keebler Daniel W. , Albertelli Jr. Paul D. , Mascarenhas Briance
Published: June 2017

Renewable energy can potentially be a source of competitive advantage, reduce greenhouse gases, and counter climate change. This study utilizes Multi-Criteria Decision Analysis to systematically assess the relative attractiveness of multiple renewable energy forms based on three factors: 1. business (economic), 2. technical (environmental), and 3. social (regulatory). It uncovers the relative attractiveness of various renewable energy forms and suggests strategies for their development for providers and customers. After considering multiple factors, the study found hydro, geothermal, and wind power to be relatively attractive renewable energy sources.
Application of Conjoint Analysis in Improving the Value of New Product Development
Authors: Galli Brian J. , Kaviani Mohamad Amin , Goldfarb Paula Steisel , Shahmaei Ardeshir
Published: June 2017

One of the most important elements of economic and business activity is developing a strategic marketing plan to improve growth prospects. One of the most important aspects of this in marketing is to understand the behavioral patterns of customers, in order to meet their needs and achieve business objectives. The consumer behavior analysis is key to establish the level of preferences expressed by the consumer towards a product or service. For this reason, conjoint analysis (CA) is one of the main models in the field of consumer research. This paper identifies the usefulness of CA as a marketing strategy in new product development (NPD). An application to “Forte Hotel Design” (presented by Lilien and Rangaswamy, 2004) is developed to highlight how CA can be an effective tool for marketing new products/services. Forte Hotels is a European hotel chain that wants to open a new facility in the United States. This research demostrates that there are multiple ways to conduct marketing research for any product or service. While the Forte Hotel case study used segmentation and targeting tools in its original analysis, the study shows that CA can also be used to analyze this marketing problem and can lead to similar decisions. This study highlights the value of CA as a tool to evaluate product attributes and shows its value in helping to make marketing decisions. It also shows that there is more than one way to dissect a marketing problem. The original case was solved using segmentation and targeting marketing tools, but this study shows that CA can be used to effectively make marketing decisions on new product development that lead to the same results/decisions as other marketing tools. This study shows original ways of using CA, to dissect a service design problem in new product development and to facilitate both product management and project management.
Fair Use Defences During Copyright Litigation
Authors: D'Rosario Michael
Published: June 2017

The prediction of legal outcomes and other legal domain related variables has served as the basis of a number of recent studies. While recent studies have estimated standardised variables and dichotomous outcomes such as the outcome of a judicial decision process, few studies have employed dichotomous data and categorical data to predict the basis of a legal defense strategy or the likelihood of trial success. Empirical research within the judicial sciences continues to employ a limited subset of empirical methods. This article reasserts the benefits of several artificial intelligence based non-parametric techniques that are better suited to the discipline than many of the common methods employed within the literature. The article considers the predictability of fair use defense within the U.S. during copyright infringement proceedings, and the likelihood of trial success.
Visual Graphetics and Language Ideology
Authors: Papadima Aspasia
Published: June 2017

There are certain sounds in the Greek-Cypriot dialect (henceforth GCD) that cannot be represented by characters from the Greek alphabet in its written form. Contradicting ideologies have made it impossible for Cypriots to settle on an official and common orthographic system, which has led to a rich variety of typographic conventions and many significant typographic drawbacks. This study aims to introduce a new set of typographic characters for the representation of the palato-alveolar GCD consonants that would provide ideal reading conditions for users (Unger, 2007; Noordzij, 2005; Bringhurst, 2005), while taking into consideration their political and cultural stances and needs. The new typographic system has been tested in two rounds of action research, providing both quantitative and qualitative data. The results show that the proposed system satisfies both the design and linguistic criteria of a successful written system as proposed by Sebba (2007), namely phonological accuracy, simplicity and readability.
Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis
Authors: Bettoni Serena , Galbusera Miriam , Gastoldi Sara , Donadelli Roberta , Tentori Chiara , Spartà Giuseppina , Bresin Elena , Mele Caterina , Alberti Marta , Tortajada Agustin , Yebenes Hugo , Remuzzi Giuseppe , Noris Marina
Published: June 2017

von Willebrand factor (VWF), a multimeric protein with a central role in hemostasis, has been shown to interact with complement components. However, results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who cannot cleave VWF multimers because of genetic ADAMTS13 deficiency, we investigated the mechanism through which VWF modulates complement and its pathophysiological implications for human diseases. Using assays of ex vivo serum-induced C3 and C5b-9 deposits on endothelial cells, we documented that in cTTP, complement is activated via the alternative pathway (AP) on the cell surface. This abnormality was corrected by restoring ADAMTS13 activity in cTTP serum, which prevented VWF multimer accumulation on endothelial cells, or by an anti-VWF Ab. In mechanistic studies we found that VWF interacts with C3b through its three type A domains and initiates AP activation, although assembly of active C5 convertase and formation of the terminal complement products C5a and C5b-9 occur only on the VWF-A2 domain. Finally, we documented that in the condition of ADAMTS13 deficiency, VWF-mediated formation of terminal complement products, particularly C5a, alters the endothelial antithrombogenic properties and induces microvascular thrombosis in a perfusion system. Altogether, the results demonstrated that VWF provides a platform for the activation of the AP of complement, which profoundly alters the phenotype of microvascular endothelial cells. These findings link hemostasis-thrombosis with the AP of complement and open new therapeutic perspectives in cTTP and in general in thrombotic and inflammatory disorders associated with endothelium perturbation, VWF release, and complement activation.
TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
Authors: Ye Jian , Wang Yadan , Liu Xia , Li Lingyun , Opejin Adeleye , Hsueh Eddy C. , Luo Huanle , Wang Tian , Hawiger Daniel , Peng Guangyong
Published: June 2017

Innate regulation through TLR signaling has been shown to be important for promoting T cell subset development and function. However, limited information is known about whether differential TLR signaling can selectively inhibit Th17 and/or Th1 cells, which are important for controlling excessive inflammation and autoimmune responses. In this article, we demonstrate that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 cells. We further report that downregulation of STAT3 signaling is responsible for TLR7-mediated inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 and 5. TLR7-mediated suppression of Th17 cells does not require dendritic cell involvement. In addition, we show that TLR7 signaling can suppress Th1 cell development and function through a mechanism different from Th17 cell suppression. Importantly, our complementary in vivo studies demonstrate that treatment with the TLR7 ligand imiquimod can inhibit Th1 and Th17 cells, resulting in the prevention of, and an immunotherapeutic reduction in, experimental autoimmune encephalomyelitis. These studies identify a new strategy to manipulate Th17/Th1 cells through TLR7 signaling, with important implications for successful immunotherapy against autoimmune and inflammatory diseases.
B Cells Produce Type 1 IFNs in Response to the TLR9 Agonist CpG-A Conjugated to Cationic Lipids
Authors: Akkaya Munir , Akkaya Billur , Miozzo Pietro , Rawat Mukul , Pena Mirna , Sheehan Patrick W. , Kim Ann S. , Kamenyeva Olena , Kabat Juraj , Bolland Silvia , Chaturvedi Akanksha , Pierce Susan K.
Published: June 2017

B cells express the innate receptor, TLR9, which signals in response to unmethylated CpG sequences in microbial DNA. Of the two major classes of CpG-containing oligonucleotides, CpG-A appears restricted to inducing type 1 IFN in innate immune cells and CpG-B to activating B cells to proliferate and produce Abs and inflammatory cytokines. Although CpGs are candidates for adjuvants to boost innate and adaptive immunity, our understanding of the effect of CpG-A and CpG-B on B cell responses is incomplete. In this study we show that both CpG-B and CpG-A activated B cells in vitro to proliferate, secrete Abs and IL-6, and that neither CpG-B nor CpG-A alone induced type 1 IFN production. However, when incorporated into the cationic lipid, DOTAP, CpG-A, but not CpG-B, induced a type 1 IFN response in B cells in vitro and in vivo. We provide evidence that differences in the function of CpG-A and CpG-B may be related to their intracellular trafficking in B cells. These findings fill an important gap in our understanding of the B cell response to CpGs, with implications for the use of CpG-A and CpG-B as immunomodulators.
Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection
Authors: Gullicksrud Jodi A. , Li Fengyin , Xing Shaojun , Zeng Zhouhao , Peng Weiqun , Badovinac Vladimir P. , Harty John T. , Xue Hai-Hui
Published: June 2017

In response to acute viral infection, activated naive T cells give rise to effector T cells that clear the pathogen and memory T cells that persist long-term and provide heightened protection. T cell factor 1 (Tcf1) is essential for several of these differentiation processes. Tcf1 is expressed in multiple isoforms, with all isoforms sharing the same HDAC and DNA-binding domains and the long isoforms containing a unique N-terminal β-catenin–interacting domain. In this study, we specifically ablated Tcf1 long isoforms in mice, while retaining expression of Tcf1 short isoforms. During CD8+ T cell responses, Tcf1 long isoforms were dispensable for generating cytotoxic CD8+ effector T cells and maintaining memory CD8+ T cell pool size, but they contributed to optimal maturation of central memory CD8+ T cells and their optimal secondary expansion in a recall response. In contrast, Tcf1 long isoforms were required for differentiation of T follicular helper (TFH) cells, but not TH1 effectors, elicited by viral infection. Although Tcf1 short isoforms adequately supported Bcl6 and ICOS expression in TFH cells, Tcf1 long isoforms remained important for suppressing the expression of Blimp1 and TH1-associated genes and for positively regulating Id3 to restrain germinal center TFH cell differentiation. Furthermore, formation of memory TH1 and memory TFH cells strongly depended on Tcf1 long isoforms. These data reveal that Tcf1 long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8+ and CD4+ T cell responses to viral infection.