bluuebunny/crossref_metadata_2025 huggingface dataset:
FACTORS AFFECTING THE HOLISTIC PERCEPTION OF UBER IN DHAKA CITY TRANSPORTATION
Authors: Farhana Noor
Published: July 2024

In recent years, Bangladesh has undergone through tremendous changes in transport sector. Because of the increased demand of mobile application-based transportation, Uber has introduced ridesharing service in Bangladesh. The main purpose of this study is to understand the overall perception regarding this new services provided by Uber in Dhaka city. In view of its importance, the present study tries to identify the factors affecting the perception of consumers, drivers and car owners of Uber. This study is conducted by surveying 100 Uber riders, 60 drivers (30 motorcycle drivers and 30 car drivers) and 20 Uber car owners from different areas of Dhaka city. Data have been analyzed using multiple regression analysis. The result of this study is expected to benefit the ride sharing service providers and to help them understand the variables influencing consumers and drivers’ perceived value. Besides, future researchers can deal with different variables to study the factors affecting the holistic perception of Uber in Dhaka.
Factors influencing consumer buying behavior
Authors: Dewan Golam Yazdani Showrav , Mohammed Masum Iqbal
Published: July 2024

Cosmetics also known as make-up kit are care stuffs used to enhance or maintain appearance or odor of the person’s body. In twenty first century the use of cosmetic is common phenomenon throughout the world. The purpose of this study is to investigate factors that have impact on consumer purchasing behavior of cosmetic products in Dhaka city, Bangladesh. In this research cosmetic means personal care products. These include, skin moisturizers, perfumes, lipsticks, shampoos, toothpastes, after shave, soap and deodorants. Independent Variables were chosen after reviewing relevant and related literature of previous studies. A random sampling survey methodology was followed and 321 completed sample responses were collected for the study. Statistical tool SPSS 20.00 was used for data analysis. Descriptive statistics was implemented in order to describe the demographic characteristics; ten independent variables have been tested to find out their influence on consumer purchase decision. Factor analysis was used to find out major factors from those variables. The research results showed that three major factors named as consumer perception, external influence and psychological motive influence purchase decision of cosmetic products in Dhaka city. This result can guide marketers to understand the purchase behavior of cosmetic product users of Bangladesh which will also help them in better segmenting this market and implementing marketing mix more effectively.
Efforts to Increase Digital Literacy in Class XII Students at Budi Agung Private Vocational School Medan
Authors: Nasib  , Harianto Adi , Juliansyah Roni , Novirsari Emma , Honkley Tony , Martin  , Hervina Sihombing Ester , Hastuty HS Widy , Amelia Ratih , Tambunan Debora
Published: July 2024

Digital literacy is the ability to use information and communication technology (ICT) effectively and critically. Digital literacy can involve the ability to find, evaluate, use and create information through various digital platforms. On this occasion, the focus was on increasing digital literacy for students in class XII of Budi Agung Private Vocational School, Medan. In this community service activity, face-to-face seminars and basic training are carried out for all students. Digital literacy can certainly provide benefits for students. The benefits that can be felt with digital literacy are that students can access various sources of information to support learning, help with assignments, teach students to evaluate the reliability and validity of online information sources which will also be useful as preparation for the world of work.
TO THE HISTORY OF THE FORMATION OF THE EDUCATIONAL CONCEPT OF LIBRARIANSHIP
Authors: Плешкевич Е.А.
Published: July 2024

Представлена история формирования и развития междисциплинарной просветительской концепции отечественного библиотечного дела в 1890-1940 гг., на основе которой была создана советская модель библиотечного дела. Показано, что отказ от этой концепции был связан с кризисом советских общественных наук, размежеванием библиотечной науки и практики с педагогикой и переориентацией общественного развития на общество потребления.

The article presents the history of the formation and development of the interdisciplinary educational concept of national librarianship in 1890-1940, on the basis of which the Soviet model of librarianship was created. It is shown that the rejection of this concept was associated with the crisis of the Soviet social sciences, the separation of library science and practice from pedagogy and the reorientation of social development to consumer society.
Calculation of the Respectability’s Index of Scientific Journals Based on Academic Degrees of Article’s Authors
Authors: Миронов В.В.
Published: July 2024

На основе краткого анализа способов повышения эффективности научных журналов в контексте авторских приоритетов рассматриваются политика и проблемы этих журналах. Выделено существенное направление усиления роли и веса журнала - эффективное управление его политикой для увеличения аудитории и представительности в научных базах данных. С этой целью (эвристически) предложены новое понятие и новый метод расчета уровня научной респектабельности (научной представительности) журнала на основе индекса, базирующегося на анализе данных об авторах его публикаций. Вводимые наукометрические индексы, в отличие от современных, основаны не на анализе цитируемости статей авторов, а на их «научном весе» в данной отрасли науки. Индексы просты в использовании, обладают свойством устойчивости (как и индекс Хирша, и его обобщения) и позволяют ранжировать научные журналы по «взвешенному» уровню участия в них, как авторов, наиболее авторитетных научных работников - докторов наук. Цель статьи - привлечь внимание читателей к конкурентноспособному методу оценки уровня научного журнала, использование которого позволит более эффективно управлять политикой журнала. Методика применена к ежемесячному сборнику «Научно-техническая информация», научно-техническому журналу «Вестник РГРТУ» и сборнику трудов V международного форума СТНО-2022 в Рязанском государственном радиотехническом университете им. В. Ф. Уткина.

A brief analysis of ways to improve the efficiency of scientific journals in the context of author's priorities has been carried out. Based on a brief analysis of the policy of scientific journals, existing problems in journals, one significant direction of strengthening the role and weight of the journal is highlighted - a new concept and a new method for calculating the level of scientific respectability (scientific representativeness) of scientific journals are proposed. The index is based on the analysis of data about the authors of journal articles. The introduced indexes are easy to use and allow ranking scientific journals according to the "weighted" level of participation in them of the most authoritative scientists represented by doctors of sciences. The purpose of the article is to offer an assessment of the respectability of the journal, which allows you to more effectively manage the policy of the journal in order to increase its audience and representativeness in scientific databases. The technique was applied to the journal "Scientific and technical information" in comparison with the scientific and technical journal "Vestnik RGRTU" and the collection of proceedings of the V International Forum STNO-2022 in Ryazan State Radio Engineering Universitynamed after V. F. Utkin.
O nível da bateria de aparelhos fotoativadores LED sem fio podem influenciar nas propriedades da resina composta?
Authors: Felizardo Klissia Romero , Gozzi Bonfim Camilly Vitória , Ahuendrya da Silva dos Santos Emanuely , Venciguerra Almeida Isabelle , Aparecida Dias Cinquini Ludmylla , Baena Lopes Murilo
Published: July 2024

A longevidade clínica e o sucesso das restaurações em resina composta estão relacionados diretamente com o processo de polimerização. Apesar de esses aparelhos apresentarem grandes evoluções, algumas unidades LED ainda podem sofrer influência quanto ao nível de bateria no decorrer do atendimento clínico, afetando assim a irradiância e comprometendo as propriedades do material restaurador. Sendo assim, o objetivo deste estudo é avaliar por meio de uma revisão bibliográfica, se o nível de carga de aparelhos fotoativadores LED tem influência nas propriedades das resinas compostas. Para a seleção dos artigos, foi realizada uma busca nas bases de dados PubMed/Medline, Scielo e Scopus, através dos seguintes descritores: falha de restauração dentária (dental restoration failure), polimerização (polymerization), diodos emissores de luz (light emitting diode), resinas compostas (composite resins). Para a filtragem dos artigos, foi aplicado o sistema de formulário avançado “AND” e utilizado o método de busca manual na lista de referência dos artigos selecionados. Com base no levantamento bibliográfico realizado, o nível de bateria de diferentes aparelhos LED pode influenciar na irradiância e grau de conversão das resinas compostas, gerando falhas nas propriedades físicas e mecânicas. Portanto, deve-se sempre manter o aparelho fotoativador carregado.
Recobrimento radicular por deslize coronal associado a enxerto subepitelial em recessão unitária em região ântero-inferio
Authors: Silva Mendes Larissa , Vasconcelos da Graça Rhaisa , Silva e Silva Emilly , Santiago Almeida Lima Manoella , Araujo Marvão Rodrigo , Vieira da Silva Gomes Carlos Eduardo , Roberto de Souza Fonseca Ricardo
Published: July 2024

Introdução: A recessão gengival (RG) é um problema comum em casos de pacientes com apinhamento dentário, especialmente, na região ântero-inferior devido a presença de tecido delgado e mau posicionamento do dente na arcada. Objetivo: O objetivo desse trabalho é relatar um caso de RG RTI de Cairo no elemento dentário 31 tratada com deslize coronal associado ao uso de enxerto subepitelial na região ântero-inferior. Relato de Caso: Paciente do sexo masculino, 32 anos de idade, sem comorbidades sistêmicas e quadros de alergias prévias foi encaminhado para uma clínica odontológica de um curso em periodontia, na cidade de Belém, norte do Brasil com a queixa principal de hipersensibilidade dentinária (HD) na região ântero-inferior. Durante exame clínico verificou-se RG tipo 1 (RT1) no dente 41, apinhamento dentário anterior na mandíbula sem a presença de lesão cervical não cariosa, fenótipo periodontal fino e festonado e sem perdas ósseas interproximais. O tratamento indicado foi o recobrimento radicular pela técnica de deslize coronal associado ao enxerto autógeno, após avaliações pré-operatórias e condicionamento da saúde bucal a cirurgia foi realizada com incisões intrasulculares nos dentes 32, 31, 41 e 42, condicionamento radicular do sítio receptor e posteriormente o enxerto subepitelial autógeno do palato duro foi suturado e por fim o retalho trazido para o local com suturas, após 90 dias de acompanhamento verificou-se recobrimento parcial do dente 41, porém ausência de HD. Conclusão: Pode-se verificar que a associação entre deslize coronal e enxerto autógeno possui resultados clínicos satisfatórios para aumento da faixa de mucosa queratinizada e ganho do nível clínico de inserção, mas em casos de apinhamento dentário faz-se necessário vincular o tratamento periodontal com ortodontia.
Reabilitação cardiovascular de pacientes submetidos à cirurgia de bypass coronário
Authors: Nogueira Rayssa Almeida , Ferreira Hian Victor Vieira , Barcelos Mariah Gomes Rangel , Moreira Júlia Maria do Prado , Neto Geraldo Pereira Cova , Júnior Pedro Delazare , Américo Judith Amaral , Almeida Lavínia Lages , Pacheco Guilherme Rodrigues , Aguiar Júlia Silveira , Paes Ana Gabriela , Bessa Heloisa Jocastra Morais , Maciel Thiago dos Santos
Published: July 2024

A revascularização miocárdica é um procedimento cirúrgico amplamente procurado, a nível global, decorrente da diminuição ou interrupção do fluxo sanguíneo para algumas regiões cardíacas, levando à isquemia miocárdica. Embora a alta recorrência e morbidade relacionada às doenças cardiovasculares, a mortalidade por esse grupo de patologias tem diminuído nos últimos anos. Contrariamente a isso, o número de pacientes submetidos às cirurgias de bypass coronário tem aumentado consideravelmente na última década, tendo em vista a elevação da expectativa de vida, que leva a alterações vasculares decorrentes do processo de senescência, além dos crescentes diagnósticos de doenças cardiovasculares basais e crônicas, como a hipertensão, o diabetes mellitus e a dislipidemia. Assim, tendo em vista o aumento no número de cirurgias de bypass coronário realizados mundialmente, além do alto potencial de morbimortalidade associado às doenças cardiovasculares no intra e pós-operatório, o presente artigo objetiva compreender a importância e a atuação da reabilitação cardiovascular na recuperação dos pacientes cirúrgicos, a fim de reinserí-los no contexto social, além de possibilitar um retorno gradual às atividades habituais. Para isso, realizou-se uma revisão da literatura, por meio da coleta de artigos originais e de revisão, publicados em inglês e português, nos últimos 25 anos, nas bases de referência bibliográfica SciELO e PubMed, o que amplia a confiabilidade do estudo. Após a análise dos artigos, percebeu-se que a reabilitação cardiovascular é fundamental no pós-operatório de pacientes submetidos à cirurgia de revascularização miocárdica e envolve uma abordagem multidisciplinar, voltada para a reabilitação fisioterapêutica, adoção de exercícios físicos supervisionados, mudanças no estilo de vida e alimentar, bem como suporte psicológico. A reabilitação, quando feita de forma adequada, reduz significativamente a mortalidade, diminui a morbidade e, por consequência, minimiza os riscos de novos eventos cardiovasculares. Assim, a reabilitação pós-operatória garante não só uma reinserção precoce do indivíduo ao meio social e às atividades habituais, como, também, melhora a capacidade funcional, diminui o risco cardiovascular reincidente e propicia o bem-estar físico e mental aos pacientes revascularizados.
Miomas > 5 cm diámetro: evolución clínica y seguimiento ecográfico. Estudio prospectivo de 5 años (2014-2018)
Authors: López Olmos Jorge
Published: July 2024

Objetivo: estudio prospectivo en una serie de 270 casos de miomas > 5 cm diámetro, de la evolución clínica y el seguimiento ecográfico para ver si hay crecimiento, durante 5 años (2014-2018). Diseño: estudio clínico de edad, paridad, abortos, imc (índice de masa corporal), nuligestas, menopáusicas, edad a la menarquía y a la menopausia, antecedentes médicos y quirúrgicos, métodos contraceptivos, trastornos ginecológicos, tipo de mioma y clínica presentada. Estudio ecográfico de seguimiento, cada 6 meses, para ver la evolución y si hay crecimiento del mioma. Se calculan los volúmenes de los miomas, el porcentaje de cambio de volumen del mioma, y se dan los intervalos de confianza al 95 %. Resultados: sobre 21.184 consultas, 270 casos de miomas > 5 cm diámetro, representan el 1,27 %. Se perdió el seguimiento en 80 casos (29,62 %), 32 casos se operaron (11,85 %), y el seguimiento clínico y ecográfico se dio en 158 casos (58,51 %). La media de edad de la serie fue 48,05 años (entre 30 y 78), la paridad media 1,24 (0-4), abortos 0,57 (0-6). Nuligestas 21,11 % y menopáusicas 21,11 % (media 52,65 años, entre 43 y 59). Tenían miomectomías previas en 7,77 %. En 82,96 % no utilizaban ningún método contraceptivo. En 5,18 % utilizaban el diu Mirena® como tratamiento de hipermenorreas. Los miomas fueron IM, intramurales, 47,77 % y SS, subserosos, 27,77 %. Se practicó histerectomía en 59,37 % y miomectomía en 31,25 %. En el seguimiento ecográfico, los volúmenes iniciales y finales fueron en cm3: en la serie, 773,19 ± 519,90 y 642,98 ± 558,96 (p < 0,05). El cambio de volumen fue descenso del 16 % (5-37 %). En las menopáusicas: 723 ± 584,08 y 434,80 ± 454,90 (p < 0,001). Con la menopausia el volumen disminuye 39 % (25-53 %) En las no menopáusicas: 795,12 ± 501,78 y 714,13 ± 575,39, sin diferencias. Hay disminución de volumen en 10 % (4-15 %). Al comparar menopáusicas y no menopáusicas en volúmenes finales hay diferencia p < 0,001. El volumen final en la menopausia es mucho menor. En los miomas IM, los volúmenes fueron 858,31 ± 608,76 y 671,56 ± 609,13. Hay un descenso del 21 % (13-29 %). En los miomas SS los volúmenes fueron: 643,70 ± 330,80 y 581,49 ± 557,04. Hay poca disminución, 9 % (7,7-9,5 %). Los miomas IM son más voluminosos inicialmente (p < 0,02).
Conclusiones: 1) Se operaron 11,85 % de los miomas: histerecto- mías en 59,37 % y miomectomías en 31,25 %. 2) El volumen del mioma a 5 años de control disminuye en 16 % (5-37 %). 3) Con la menopausia disminuyen más, 39 % (25-53 %) que, en no me- nopáusicas, 10 % (4-15 %). 4) Los miomas IM disminuyen 21 % (13- 29 %), más que los SS, que disminuyen 9 % (7,7-9,5 %).
Reseña del uso de la Clasificación CO-RADS en el Hospital Regional ISSEMyM
Authors: Hernández Miranda Marha Berenice , Godínez Tamay Edgar Daniel , Victal Vázquez Guillermo , Carmona Sánchez Hugo Arturo , López Dionicio Caballero , Jiménez López Gabriel
Published: July 2024

Objetivo General: Describir los hallazgos tomográficos en los pa- cientes hospitalizados por Covid-19 en el Hospital Regional Isemmym Toluca, durante el periodo de mayo a diciembre 2020. Material y Métodos: retrospectivo, transversal y observacional, se revisaron 173 tomografías por médicos radiólogos, después de ser revisado por cómite de ética.
Resultados: el rango de edad fue de 22 a 87 años. Se encontró que 94 pacientes eran del género masculino (54.3%) y 79 eran del género femenino (45.7 %). Con relación a la presencia de comorbilidades se observó que 45.1 % (78) de la muestra que estos pacientes no padecen ninguna enfermedad, sin embargo, se observa 16.8 % (29) tiene DM2 y HAS. 59 % pertenece a la clasificación 5 de Co-rads, siendo este más frecuente en los hombres y sin comorbilidades.
Conclusión: se menciona que la tomografía no puede reemplazar a la prueba PCR pero que puede ser una guía para aquellos pacientes con pruebas PCR falsas, además de ayudar en su diagnóstico y pronóstico.
Revisión rápida de la farmacología del sobrepeso y la obesidad
Authors: Arriaga Izabal Diego Yahir , Canizalez Roman Adrian
Published: July 2024

En el último siglo, el aumento significativo de la prevalencia internacional de la obesidad y el sobrepeso ha sido de gran preocupación en el mundo actual por sus implicaciones en distintas comorbilidades y su enorme costo económico. La intervención integral en el manejo de la pérdida de peso conlleva cambios importantes en el estilo de vida y en ocasiones, el empleo farmacológico. El objetivo del presente trabajo es exponer una revisión actualizada de la farmacología la obesidad y el sobrepeso Se realizó una búsqueda de los términos “farmacoterapia”, “obesidad", “sobrepeso” y “manejo farmacológico” y sus equivalencias en inglés en PubMed y Google Académico durante las primeras semanas de marzo de 2023. En conclusión, el mejor entendimiento de los mecanismos fisiopatológicos ha facilitado en el desarrollo de nuevos fármacos con menores efectos adversos y más efectivos; así mismo, la farmacoterapia es solo un coadyuvante en el abordaje multidisciplinario con el propósito de mejorar la adhesión al tratamiento.
Percepción subjetiva de ansiedad y conducta alimentaria durante el confinamiento por COVID-19 en adultos guanajuatenses
Authors: Fernández Carrasco María Del Pilar , Otero Zavala Luz Clarita , Miranda Díaz Elsa Victoria , López Ortiz María Monserrat
Published: July 2024

Introducción: La pandemia por COVID-19 ocasionó el confinamiento para evitar su propagación, generando angustia que podría modificar la conducta alimentaria.
Objetivo: Comparar la percepción subjetiva de ansiedad con la conducta alimentaria durante el confinamiento por COVID-19 en adultos guanajuatenses.
Material y métodos: Estudio observacional, transversal y comparativo, mediante encuesta en línea en redes sociales. Se solicitaron datos sociodemográficos, percepción de ansiedad y se aplicó el Cuestionario de Tres Factores de la Alimentación (TFEQ-R18-SP). Análisis estadístico mediante prueba T de student para grupos independientes y ANOVA.
Resultados: Participaron 672 sujetos (69.3% femenino), edad promedio 28.3+12.4 años, meses en confinamiento 5.4+1.8, percepción de ansiedad 66.8% sin diferencias significativas por nivel de confinamiento. Puntajes para conducta alimentaria: Desinhibición 15.5+5.3, Ingesta emocional 5.1+2.2 y Restricción cognitiva 12.1+3.5. La comparación según ansiedad mostró diferencias estadísticamente significativas en desinhibición (p<0.001), ingesta emocional (p<0.001) y restricción cognitiva (p=0.04).
Conclusiones: Tras 6 meses de confinamiento casi 7 de cada 10 participantes percibió ansiedad, principalmente mujeres y personas con disminución de actividad física. En el grupo que presentó ansiedad percibida se identificaron puntajes más altos en los tres factores de la conducta alimentaria.
Estrategias nutricionales para la disminución de Long COVID-19. Una Revisión de la literatura
Authors: Orozco González Claudia Nelly , Sosa Garcia Betsy Corina , Garduño Alanis Adrina , Becerril Alarcon Yizel , Morales Díaz Ruth Berenice
Published: July 2024

Introducción:
La pandemia por la COVID-19, se originó por el virus SARS-CoV-2, afectando a más personas con comorbilidades preexistentes, baja actividad física y estilos de vida no saludables. Se conoce que antes de la pandemia, la alimentación de las personas era deficiente, por lo que existe una gran necesidad de seguir estrategias nutricionales para la prevención de infecciones por Long COVID-19.
Objetivo:
Identificar las estrategias nutricionales para la disminución de Long COVID.
Material y métodos:
Se hizo una búsqueda exhaustiva de fuentes de datos electrónicos en PubMed, Web of Science, RedAlyC, Google Scholar, Biblioteca Cochrane, y Scopus, publicados en el periodo de 2020- 2023, utilizando términos MeSH “nutrición” “estrategias nutricionales” “COVID-19”, “pautas nutricionales y “recomendaciones nutricionales” No se aplicaron restricciones de idioma siguiendo las directrices en la norma PRISMA.
Resultados:
Se seleccionaron 19 estudios publicados en el periodo 2020 y 2023, de tipo cohorte, ensayo clínico, transversal y prospectivo. Al analizar la información, se identificó tres temas relacionados con el efecto de la nutrición y Long COVID: i) adherencia a la dieta mediterránea, ii) calidad de dieta y iii) intervención nutricional con suplementación de componentes no energéticos. La dieta mediterránea fue la terapia nutricional más recomendada debido a la calidad de alimentos y los beneficios en la enfermedad cardiovascular, sensibilidad a la insulina y perfil de lípidos, y disminución de la inflamación, siendo el sexo femenino reporta mayor adherencia del 77% teniendo como resultado niveles más bajos de triglicéridos, IMC, perímetro abdominal y citocinas proinflamatorias.  
Conclusiones:
Una nutrición adecuada para todas las células del sistema inmunológico tendrá una función homeostáticamente, esto a través del seguimiento y cumplimiento de estrategias que propicien un estilo de vida saludable.
Intervención educativa en farmacovigilancia dirigida al personal de salud de una clínica de medicina familiar
Authors: Vázquez Alvarado Mario Ivan , Prado Galbarro Francisco Javier , Heyerdahl Viau Ivo , Vázquez Moreno Everardo , García Casas Mireya , Martínez Núñez Juan Manuel
Published: July 2024

La farmacovigilancia (FV) ha ayudado a detectar y prevenir reacciones adversas relacionadas a los medicamentos (RAMs). Sin embargo, algunos factores, como conocimientos deficientes en FV y falta de interés del personal de salud, limitan su aplicación y favorece la subnotificación de las RAMs. En el presente estudio se realizó una intervención educativa sobre FV dirigida al personal de salud que labora en una clínica de medicina familiar del ISSSTE y evaluar sus efectos en términos de conocimientos, actitud, práctica y experiencia. Se aplicó un cuestionario, antes y después de la intervención, constituido por 11 preguntas relacionadas con los conocimientos, 4 relacionadas con la actitud hacia la FV y 6 preguntas relacionadas con la práctica y experiencia en FV. Participaron 60 profesionales. Hubo mejoras significativas en conocimientos sobre FV, mientras que en términos de actitud hacia la práctica de la FV no hubo cambios significativos, aunque los resultados mostraron una buena actitud de los participantes desde antes de la intervención. Respecto a la práctica y experiencia en FV, la mayoría ha detectado una RAM en los pacientes que atiende, pero no la ha reportado al respectivo centro de FV principalmente debido a la falta de tiempo.
AVANÇOS NA TERAPIA COM CÉLULAS CAR-T PARA LEUCEMIA LINFOBLÁSTICA AGUDA EM PEDIATRIA: UM ENFOQUE EM EFETIVIDADE CLÍNICA E PERSPECTIVAS FUTURAS
Authors: Dandara Cristina da Silva  , Naiara Pereira Rodrigues  , Sângela de Jesus  , Afrânio Côgo Destefanio
Published: July 2024

A leucemia linfoblástica aguda (LLA) é o câncer mais comum na infância, representando uma parte significativa das leucemias pediátricas. Apesar dos avanços na quimioterapia, uma proporção substancial de pacientes pediátricos ainda enfrenta recidiva ou resistência ao tratamento. A terapia com células CAR-T (Chimeric Antigen Receptor T-cell) surgiu como uma abordagem inovadora para neoplasias hematológicas refratárias e recidivantes. Este estudo tem como objetivo avaliar a eficácia e segurança da terapia com células CAR-T no tratamento de LLA em crianças. Foram incluídos estudos publicados nos últimos dez anos que investigaram a eficácia da terapia em pacientes pediátricos com LLA. Os resultados mostraram que a terapia CAR-T alcança taxas de remissão completa entre 70% e 90%, com uma sobrevida livre de doença de 50% a 70% e uma sobrevida global de 55% a 75%. Embora a síndrome de liberação de citocinas (SLC) e a neurotoxicidade tenham sido observadas em 35% e 15% dos casos, respectivamente, a maioria dos eventos adversos foi manejável com intervenções clínicas adequadas. A comparação com tratamentos convencionais revelou que a terapia CAR-T proporciona uma eficácia superior e um perfil de toxicidade mais favorável. Conclui-se que a terapia CAR-T é uma opção promissora para o tratamento da LLA pediátrica, embora desafios relacionados à produção, custo e gerenciamento de efeitos adversos ainda precisem ser superados. A continuidade da pesquisa é essencial para otimizar esta terapia e expandir seu acesso.
VISÃO GERAL SOBRE OS PRODUTOS NATURAIS E SUAS APLICAÇÕES: UMA REVISÃO
Authors: Gislaine Silva-Rodrigues
Published: July 2024

Produtos naturais são substâncias bioativas obtidas de fontes naturais como plantas, microrganismos, algas e animais, que podem possuir diversas propriedades terapêuticas. No presente estudo é abordado os principais bioativos extraídos das fontes de produtos naturais, como os alcaloides, terpenos, terpenoides, polifenóis e fenilpropanoides; além dos seus métodos de extração, purificação, identificação e as análises químicas e biológicas. Essa abordagem permite entender e caracterizar os ativos para avaliar suas propriedades terapêuticas, e garantir sua aplicabilidade na medicina tradicional ou medicina moderna, como a fitoterapia e homeopatia. Para obtenção destes produtos, é importante destacar a necessidade de conservação da biodiversidade, propiciando a obtenção continua destes e de novos compostos bioativos. No entanto, a pesquisa enfrenta desafios, incluindo a complexidade da extração, a variabilidade dos compostos e a necessidade de validação clínica rigorosa. A interdisciplinaridade na pesquisa e a conservação ambiental são fundamentais para explorar os benefícios dos produtos naturais, combinando conhecimentos tradicionais e avanços científicos para inovar na saúde humana.
AVALIAÇÃO DO USO DAS TECNOLOGIAS DIGITAIS DE INFORMAÇÃO E COMUNICAÇÃO (TDICS) COMO FERRAMENTA AUXILIAR NO ENSINO DA HISTOLOGIA: REVISÃO INTEGRATIVA DA LITERATURA
Authors: Rebeca Lucena Leandro  , Gustavo Medeiros Toscano da Silva  , Luan Everton Galdino Barnabé  , Marcos Alexandre Casimiro de Oliveira  , Clarissa Lopes Drumond  , José Klidenberg de Oliveira Júnior
Published: July 2024

O artigo analisa o papel das Tecnologias Digitais de Informação e Comunicação (TDICs) no ensino de Histologia em cursos da área da saúde. Considerando o avanço tecnológico e o acesso cada vez mais facilitado a essas tecnologias, especialmente entre jovens, o estudo aborda como essas ferramentas influenciam o aprendizado e o ensino da Histologia. A pesquisa segue uma metodologia de revisão integrativa da literatura, analisando estudos científicos publicados entre 2012 e janeiro de 2024.Os principais objetivos incluem avaliar a eficácia das TDICs, como computadores, tablets, celulares e internet, na facilitação do processo de ensino-aprendizagem de Histologia. A revisão abrange a utilização de vídeos, plataformas online, aplicativos e mídias sociais, destacando seu impacto positivo na compreensão e retenção de conteúdos complexos, como a visualização tridimensional de tecidos, que é difícil de alcançar com métodos tradicionais. Os resultados indicam que a implementação das TDICs  tem sido benéfica, proporcionando maior acessibilidade a materiais educativos e facilitando a aprendizagem autônoma e colaborativa. No entanto, ressalta-se que essas tecnologias não substituem a figura do professor, mas sim complementam o processo educativo, oferecendo ferramentas adicionais para a consolidação do conhecimento. A revisão conclui que as TDICs, quando integradas de forma adequada no currículo de Histologia, podem melhorar significativamente o desempenho e a satisfação dos estudantes, promovendo um ambiente de aprendizado mais dinâmico e interativo.
PROFILAXIA PRÉ-EXPOSIÇÃO AO HIV (PREP): DESAFIOS E PERSPECTIVAS NA IMPLEMENTAÇÃO NO SISTEMA ÚNICO DE SAÚDE (SUS) NO BRASIL
Authors: Hudson Rosa da Silva Leão Filho  , Isadora Engel Marques  , Amanda Vieira de Aguiar  , Vitória Roberta Andrade Silva  , Fernanda Oliveira da Costa Caetano  , Flavia Barcelos Cardoso  , Rafael Alves Ferreira de Almeida  , Marcos Ferreira Machado  , Gabriel Cabriny Doutor  , Matheus Henrique Mendes de Oliveira  , Tiago Nogueira de Abreu
Published: July 2024

A Síndrome da Imunodeficiência Adquirida (AIDS), causada pelo Vírus da Imunodeficiência Humana (HIV), continua a representar um desafio global significativo para a saúde pública desde sua identificação. A introdução da Profilaxia de Pré-Exposição ao HIV (PrEP), uma estratégia inovadora que utiliza antirretrovirais para prevenir a infecção, marca um avanço promissor na prevenção do HIV. Este estudo revisa a implementação da PrEP no Brasil, focando nos desafios e nas perspectivas de sua aceitação e eficácia entre populações de maior vulnerabilidade. A metodologia empregada incluiu uma revisão narrativa de estudos publicados na plataforma SCIELO, resultando na análise de quatro artigos selecionados que exploram desde o conhecimento e a prática clínica dos profissionais de saúde até as percepções e experiências das populações vulneráveis. Os resultados destacam a eficácia da PrEP na redução da incidência do HIV, porém revelam disparidades significativas no acesso e na disseminação da PrEP, além de desafios relacionados ao estigma e à falta de recursos. Conclui-se que uma abordagem integrada, que combine estratégias medicamentosas e comportamentais, é essencial para uma redução sustentável da prevalência do HIV e para promover uma saúde pública mais inclusiva e abrangente.
INITIAL IMPLEMENTATION OF THE MATATAG CURRICULUM: VIEWS OF THE TEACHERS
AND PRINCIPALS
Authors: Jamaica Clarisse U. Lagbao
Published: July 2024

The matatag curriculum represents a significant step in enhancing the K to 12 Basic Education Program in the Philippines. It acknowledges the challenges faced, the demands of the 21st century, and the importance of assessment data in curriculum development. The recommendations provided will guide the recalibration of the curriculum to better prepare learners for the future. The curriculum review process examines the intended, implemented, assessed, and achieved curriculum phases. Narrative analysis offers the opportunity for more attention to language form, social context, and audience than other approaches. It also treats extended accounts as units, rather than fragments. For example, phenomenological research focuses on the lived experience, but narrative studies focus on the details of how and why a certain event is part of the story that is being told. The target population consisted of teachers and principals with at least ten years of teaching experience in order to draw comparison between the old curriculum (before K-12), the current curriculum (K-12) and the soon to be implemented curriculum (matatag curriculum). My rationale for using this time period is that the different views and opinions of teachers and school principals on the implementation of the matatag curriculum next school year 2024-2025. The findings indicate significant positive changes, evident in the Matatag curriculum compared to its predecessor, as elucidated in the curriculum guides published by the Department of Education. Notably, the Matatag curriculum offers opportunities for the localization and contextualization of elementary generalist lessons. This paper contributes fresh insights into how various stakeholders perceive the forthcoming implementation of the Matatag curriculum in the upcoming school year. Recommendations for improvement include additional training for educators, development of comprehensive support materials, and mechanisms for ongoing monitoring and evaluation. By addressing these challenges and implementing these recommendations, policymakers can enhance the effectiveness and impact of the Matatag Curriculum, paving the way for a more equitable, inclusive, and responsive education system in the Philippines.
KEYWORDS: Initial Implementation, Matatag Curriculum, Views of the Teachers, Principals
INCLUSIVE EDUCATION INITIATIVES: A NARRATIVE EXPOSITIONS OF TEACHERS
Authors: Elena S. Cohitmingao
Published: July 2024

Inclusive education, as a philosophy and practice, has been gaining prominence in educational systems around the world. It represents a fundamental shift in the way we perceive and accommodate the diverse needs of students within mainstream classrooms. This study employed qualitative research as the method to Evaluate the Efficacy of Inclusive Education Initiatives at Sta. Maria Integrated School. A qualitative phenomenological study employing in-depth interviews was the design used for this undertaking. Phenomenology searches for the meaning or essence of an experience rather than measurements or explanations. The research participants will be the eight (8) General Education Teachers who are employed Sta. Maria Integrated School. They will be responsible for instructing students in inclusive classrooms can provide information on teaching methods, curriculum adaptations, and their perceptions of inclusive education. significant finding relates to the challenges faced by teachers due to the lack of specialized training in inclusive education. Many educators expressed feeling overwhelmed by the need to individualize instruction and support for each student, particularly without adequate preparation during their pre-service education programs. This underscores the importance of continuous professional development and support to equip teachers with the knowledge and skills necessary to effectively manage diversity in inclusive classrooms. Teachers should advocate for inclusive policies and practices at the school, district, and systemic levels to create supportive environments for all students. This may involve participating in school leadership teams, policy development committees, or advocacy campaigns focused on issues such as inclusive curriculum design, equitable access to resources, and anti-discrimination policies. By amplifying their voices and collaborating with stakeholders across the education system, teachers can drive positive change and promote inclusivity for all learners.
KEYWORDS: Inclusive Education Initiatives, Narrative Expositions
Experiences of racism of Black medical students and residents in Montréal: “I wear my stethoscope around my neck at all times”
Authors: Soares Roberta , Magnan Marie-Odile , Liu Yifan , Henri Margaret , Leduc Jean-Michel
Published: July 2024

Background: Black students and residents experience racism in medical school. This qualitative study documents Black students’ and residents’ experiences of racism using Critical Race Theory (CRT) and explores their coping mechanisms using the theatrical metaphor.
Methods: We conducted semi-structured interviews with four Black medical students and residents (two medical students and two residents) studying in Montréal and analyzed their experiences through counter-stories. We identified themes related to their experiences of racism during medical training and their coping mechanisms.
Results: Our analysis reveals these experiences of racism occur in academic and clinical settings (classes, internships, social interactions with peers, faculty, and patients, and through the curriculum), in the form of microaggressions. The analysis also indicates that Black students and residents try to cope with racism using a hyper-ritualization strategy to better fit in (e.g., clothing, behaviours).
Conclusion: Considering that Black students and residents experience various forms of racism (subtle or explicit) during their medical training, these findings urge us to increase awareness about racism of students, residents, teachers and health care workers in universities and teaching hospitals. Pathways to increase the representation of Black students and residents seem to be part of the solution, but improving the learning environment must be a priority to improve racial justice in medical training in Québec.
Eight ways to get a grip on validity as a social imperative
Authors: Marceau Mélanie , Young Meredith , Gallagher Frances , St-Onge Christina
Published: July 2024

Validity as a social imperative foregrounds the social consequences of assessment and highlights the importance of building quality into the assessment development and monitoring processes. Validity as a social imperative is informed by current assessment trends such as programmatic-, longitudinal-, and rater-based assessment, and is one of the conceptualizations of validity currently at play in the Health Professions Education (HPE) literature. This Black Ice is intended to help readers to get a grip on how to embed principles of validity as a social imperative in the development and quality monitoring of an assessment. This piece draws on a program of work investigating validity as a social imperative, key HPE literature, and data generated through stakeholder interviews. We describe eight ways to implement validation practices that align with validity as a social imperative.
What do we know about Objective Structured Clinical Examination in Sport and Exercise Medicine? A scoping review
Authors: El Sherif Reem , Shrier Ian , Tellier Pierre-Paul , Rodriguez Charo
Published: July 2024

Background and objectives: Despite the importance of the Objective Structured Clinical Examination (OSCE) in Sport and Exercise Medicine, the literature on the topic is fragmented and has been poorly developed. The goal of this review was to map current knowledge about how the OSCE is used in Sport and Exercise Medicine, and to identify knowledge gaps for future research.
Method: The authors conducted a scoping review. They searched PubMed and Scopus for articles using key terms related to 'OSCE' and 'sport medicine' with no limit on search start date and up to July 2022. Retrieved records were imported, abstracts were screened, and full-text articles were reviewed. A forward and backward citation tracking was conducted. Data was extracted and a qualitative meta-summary of the studies was conducted.
Results: A total of 469 records were screened, and 22 studies were included. The objectives of the studies included using OSCEs to assess knowledge/skills after a training program (n = 11), to assess an intervention (n = 8), and to assess and improve the OSCE itself (n = 3). Thirteen studies reported validity and/or reliability of the OSCE.
Conclusion: Despite the widespread use of OSCEs in the examination of Sport and Exercise Medicine trainees, only a handful of scholarly works have been published. More research is needed to support the use of OSCE in Sport and Exercise Medicine for its initial purpose. We highlight avenues for future research such as assessing the need for a deeper exploration of the relationship between candidate characteristics and OSCE scores.
Patch Formulation of Rambusa (Passiflora foetida) Leave Extract as Anti-Inflammatory Agent: An In Vitro and In Vivo Study
Authors: Setyaningrum Lindawati , Aliyah Purwanti  , Widaddhiya Zahra Anggraini  , Adelia Royan Suryani  , Tolak Haris  , Lubis Nuril Ubaidilla
Published: July 2024

Rambusa leaves are known to have health benefits, including anti-inflammatory, antitumor, anticancer, antihepatotoxicity and antimicrobial. Rambusa leaves contain active compounds including alkaloids, tannins, saponins, and steroids which have anti-inflammatory effects. So it was developed as a transdermal route preparation in the form of a patch to overcome the problem of side effects from using oral medications on the gastrointestinal tract. Rambusa leaves are formulated into additional ingredients in the form of HPMC, methyl paraben, propylene glycol, 96% ethanol, distilled water and made into ready-to-use patches. Furthermore, an evaluation of the physical quality of the formula was carried out and its anti-inflammatory effectiveness was determined through in vitro and in vivo tests. The results show that each formula produces physical properties that meet the requirements. Apart from that, the results of the in vitro test using sodium diclofenac as a standard show that formulas 100, 200 and 300 are able to penetrate the membrane from the results of the cumulative amount of active ingredients that have been tested, whereas in the in vivo test using wistar rat test, the results of % edema were analyzed using ANOVA and the results of % inhibition were carried out in a post hoc test with LSD. The highest effectiveness was obtained in formula 300, this shows that the formula is capable of inhibiting inflammation. From these results it can be concluded that rambusa leave extract can be developed into a transdermal patch formula for anti-inflammation.
CALENDAR ANOMALIES IN THE RUSSIAN ENERGY STOCK MARKET: TRENDS OF THE LAST YEAR
Authors: Marshalov D.P. ,   4th Year Student, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Tran Hoang Hieu , Sebbagala T.M. , Rodionov Dmitry G. , Kryzhko Daria A. ,   Graduate Student, Assistant, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia,   Senior Lecturer, Makerere University, Kampala, Uganda,   Doctor of Science (Economic), Professor, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia,   Graduate Student, Assistant, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Published: July 2024

This study is dedicated to the analysis of calendar anomalies, specifically the profitability of energy companies' stocks on different days of the week. Special attention is given to examining differences in stock returns and identifying correlations between various trading days. The goal is to determine whether there are statistically significant differences in the returns of companies within the same sector depending on the day of the week. For the analysis, a dataset was compiled containing the stock prices of 12 energy companies over the past year. Descriptive statistics for three randomly selected companies were analyzed, including the calculation of the mean, median, standard deviation, and percentiles of returns for each day of the week, as well as the probability of returns, skewness, and kurtosis of the return distributions. Based on the data obtained, a variance analysis (Ftest) was conducted to determine the presence of statistically significant differences in average returns by day of the week. Additionally, using multivariate analysis (Tukey's test), specific pairwise differences between days were investigated. Correlation analysis was employed to identify relationships between returns on different days of the week. The results of the analysis confirmed the presence of calendar anomalies in the returns of energy companies' stocks, revealing significant differences between specific days of the week. These findings can be used to develop trading strategies on the stock market that take calendar anomalies into account, potentially increasing the efficiency of investment decisions.
STUDY OF THE PREDICTIVE ABILITY OF THE DECISION TREE ALGORITHM TO DETERMINE THE PROFITABILITY OF STOCKS
Authors: Marshalov D.P. ,   4th Year Student, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Tran Hoang Hieu , Sebbagala T.M. , Popova S. , Konnikov Evgeny A. ,   Graduate Student, Assistant, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia,   Senior Lecturer, Makerere University, Kampala, Uganda,   Graduate Student, Assistant, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia,   Candidate of Economic Sciences, Associate Professor, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Published: July 2024

The purpose of this study was to evaluate the effectiveness of using a decision tree algorithm to predict the profitability of technology company stocks based on the analysis of financial indicators. The study was based on the analysis of financial indicators such as return on sales (ROS), earnings per share (EPS), cost of sales, selected as independent variables to analyze the performance of leading technology companies: Google, Meta, Microsoft and Apple. The decision tree model was applied using the scikitlearn library, where the dependent variable was the return on shares of the named companies. The research methodology involved assessing the effectiveness of the model using criteria such as an error matrix (confusion) and prediction accuracy. The results of the analysis showed that the decision tree model demonstrates high efficiency in predicting stock returns based on the analyzed financial indicators, achieving an accuracy of 0,8 and responsiveness of 0,875. However, the study revealed a number of limitations associated with the failure to take into account certain external factors and financial indicators that can significantly affect stock performance.
MACHINE AND DEEP LEARNING APPROACHES USED TO INTERPRET ECGS AND DETECT CARDIAC PATHOLOGIES
Authors: Gorovoy Yuriy M. ,   Associate Professor of the Department of Information Systems and Technologies of Yaroslavl State Technical University, Yaroslavl, Russia, Kuricyna Angelina V. , Voevodina Elena I. ,   Student, Yaroslavl State Technical University, Yaroslavl, Russia,   Senior Lecturer at the Department of Information Systems and Technologies of Yaroslavl State Technical University, Yaroslavl, Russia
Published: July 2024

The article discusses existing approaches and technologies in the field of machine and deep learning used to interpret electrocardiograms (ECGs) and detect pathologies of cardiac activity. The main methods of information extraction, classification and data analysis are reviewed, and the problems faced by traditional research methods in this area are identified. In particular, the use of machine learning methods for the interpretation of ECG is considered, which includes both traditional approaches with manual feature extraction and modern methods of automated analysis. The main attention is paid to the morphological characteristics of key ECG elements, such as the QRS complex, T wave and J point, for which various parameters are determined, including amplitude, duration and shape. The selection and analysis of these signs is aimed at identifying abnormal cardiac conditions.