bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving marketing skills through logo design training for the local business community
Authors: Ranuharja Fadhli , Indrayeni Wiwik , Samala Agariadne Diwnggo , Hasim Abdul , Larashati Chintiya
Published: February 2023

Sangir Regency which is located in South Solok Regency, West Sumatra, Indonesia is potential for culinary tourism because the data obtained by the number of local entrepreneurs in the Sangir Nagari Sungai Kunyit area reveal that several communities of local entrepreneurs engaged in home-based culinary businesses. The lack of use of technology to grow the selling value of regional products is an obstacle for local business communities to develop their businesses. Local entrepreneurs lose competitiveness if they want to market their products more broadly. The demographic location of Nagari Sungai Kunyit, which is quite far from the city of Padang Aro, also makes the inclusion of marketing trend technology not well utilized by the community. The method used in this service activity is the following: the first step was preparation, including observation and licensing administration; the second step was training in a 2-day successive workshop; the third step was 1-day evaluation; and the last step was product marketing assistance through the UNP Faculty of Tourism and Hospitality. The existence of skills development training activities has succeeded in increasing the resources of the local Nagari Sungai Kunyit business community in the field of making logos, which have become reinforcements, providing added value to the products produced. Furthermore, it helps small entrepreneurs to make products more attractive because they have the characteristics of their respective logos. Increasing human resources in the field of branding design is expected to spur an increase in the people's economies in South Solok Regency. It is proven that this activity has increased local business sales turnover and entrepreneurs are more confident in marketing their products outside the region.
I Don’t Wanna Die: Punk Rock Music and Culture as Critical Social Work Practice
Authors: Farr Paddy
Published: February 2023

Punk is a music genre and counter-culture that has provided community and empowerment to generations of traumatized youth. This article is a case study on the use of punk rock counter-culture through the expression of music as a critical social work practice within a psychiatric outpatient clinic. The clinic, Lane County Behavioral Health, was founded during the deinstitutionalization era of psychiatric care for the treatment of “severe and persistent mental illness.” The article describes the formation of the group, the shared personal and cultural history of the therapist with group members, and the critical engagement with psychiatric violence generated through the composition of punk music. In this, the process of composition and the lyrical content of four songs are provided. Each of these four songs demonstrate a connection of the personal experiences of psychiatric violence to a political protest against psychiatric violence. While the article focuses on the experience of punks in the psychiatric clinic, the implementation of relationality and personal-political experience are applicable beyond the punk counter-culture. The article concludes with discussion elaborating ways in which a relational analytic group can be implemented within tight knit counter-cultural communities.
Analisis Economic Value Added (EVA) Pada Perusahaan Sektor I yang Terdaftar di Jakarta Islamic Index (JII)
Authors: Zulhilmi Muhammad , Safitri Winny Dian , Rahmi Rahmi
Published: February 2023

Tujuan penelitian ini adalah untuk mengetahui keuntungan perusahaan, kinerja keuangan dan perubahan tingkat kinerja perusahaan sektor industri selama bergabung di Jakarta Islamic Index (JII) tahun 2014, 2015 dan 2016. Jenis data yang digunakan ialah data sekunder yang berasal dari laporan-laporan keuangan setiap perusahaan sektor industri yang tergabung dalam Jakarta Islamic Index tahun 2014 sampai 2016, khususnya laba/rugi dan posisi keuangan yang menjadi dasar perhitungan EVA (Economic Value Added). Hasil penelitian ini menunjukkan bahwa perusahaan sektor industri yang bergabung di Jakarta Islamic Index (JII) memiliki laba yang meningkat setiap tahunnya, tetapi nilai EVA yang dimiliki oleh perusahaan sektor industri kurang baik. Hal ini dapat dilihat dari 7 perusahaan yang menjadi objek penelitian dari 3 periode yaitu tahun 2014, 2015 dan 2016, dimana hanya 2 perusahaan diantaranya yang memiliki nilai EVA yang meninggat walaupun pada tahun 2015 mengalami penurunan, tetapi pada tahun 2016 kembali meningkat. Perusahaan tersebut adalah PT Astra International Tbk dan PT Indocement Tunggal Prakarsa Tbk
Prilaku Pengusaha Elektronik Menurut Perspektif Etika Bisnis Islam (studi Kasus di Kota Banda Aceh
Authors: Ayumiati Ayumiati , Ibrahim Azharsyah , Arifin Muhammad , Isnaliana Isnaliana
Published: February 2023

Peneliti bertujuan melihat perilaku dari pengusaha elektronik di kota Banda Aceh dalam menentukan harga menurut etika bisnis islam dana pa saja faktor-faktor yang mempengaruhi perilaku dari pengusaha elektrronik dalam praktik jual beli. Hasil penelitian menunjukkan bahwa perilaku setiap pengusaha elektronik sangat di pengaruhi dengan motif keuntungan dan merekan tidak mengindahkan nilai-nilai yang terkadung dalam konsep etika Islam dalam bermuamalah dan faktor yang mempengaruhi pengusaha elektronik dalam menjual barangnya adalah merupakan harga, persepsi, kelangkaan dari barang dagangan, pengetahuan dari pengusaha elektronik, kejujuran serta dari segi pelayanan.
Respon Masyarakat Aceh Terhadap Wakaf Asuransi Jiwa Syariah
Authors: Jalaluddin Jalaluddin
Published: February 2023

Persepsi/respon terhadap Asuransi Jiwa Syariah belum baik di masyarakat, apalagi wakaf  asuransi. Hal ini dapat dilihat pada perusahaan yang sudah  menjual produk syariah lebih dari  lima meliputi: PT.Asuransi Takaful Keluarga, PT. AIA, PT. Bumi Putera, PT. Prudensial Syariah hanya rata-rata 20 (dua puluh)  polis perbulan yang artinya kurang dari satu polis perhari. Tujuan dari penelitian ini apakah dengan adanya produk wakaf polis asuransi akan ada perubahan persepsi masyarakat terhadap asuransi di tanah air, khususnya Aceh. Karena konsep wakaf dan asuransi sedikitnya ada kesamaan untuk kemaslahatan keluarga dan umum. Metode penelitian yang dilakukan adalah penelitian kualitatif deskriptif  yaitu dengan cara wawancara secara mendalam kepada responden terpilih yang meliputi Badan Wakaf Indonesia (BWI) Provinsi Aceh, Majelis Permusyawaratan Ulama (MPU) Provinsi Aceh, akademisi, praktisi (perusahaan asuransi), nasabah asuransi, dan ulama dayah/pesantren. Penelitian tergolong penelitian lapangan (field research) dan kepustakaan (library research. Adapun hasil dari penelitian ini terbagi ke dalam dua  persepsi/respon yaitu sangat positif dan normal/sedang demi kemaslahatan umat.
ANALISIS PRAKTIK MANAJEMEN INVESTASI PADA WAKAF UANG DITINJAU DARI MASLAHAH MURSALAH
Authors: Indra Fadhilah Sukur , Rosalina Namira Muthi’a , Mustofiyyah Zakiyyatul
Published: February 2023

Perwakafan di Indonesia mulai berkembang sejak diberikannya Undang-Undang No.41 tahun 2004 tentang perwakafan sebagai payung hukum untuk wakaf, salah satu bukti dari perkembangan ini adalah munculnya bermacam-macam bentuk wakaf salah satunya wakaf uang. Wakaf uang yang diberikan oleh wakif kemudian akan dikelola nazhir dengan cara menginvestasikanya kebeberapa sektor. Lalu dengan penginvestasian tersebut beberapa masyarakat akan bertanya bagaimana cara penyaluran manfaat sehingga dapat dirasakan oleh seluruh komponen masyarakat. Maka penelitian ini bertujuan untuk melihat konsep manajemen investasi didalam wakaf uang dan konsep maslahah mursalah yang terkandung didalamya. Metode yang dilakukan adalah library research dengan menggunakan beberapa referensi jurnal. Hasil penelitian bahwa pelaksanaan manajemen investasi dalam wakaf tunai adalah dengan menginvestasikannya kepada sektor riil seperti sekolah dan proyek-proyek tanah wakaf. Dengan ini dapat dikatakan bahwa maslahah yang terkandung didalamya untuk kemaslahatan umat dan dapat dirasakan secara langsung oleh masyarakat
Pengaruh Minat, Religiusitas, dan Prestasi Belajar Mahasiswa Perbankan Syariah Terhadap Kesiapan Bekerja Pada Bank Syariah
Authors: Navisha Dhea , Ahmadsyah Israk , Ismuadi Ismuadi
Published: February 2023

Bank Syariah merupakan Bank yang kegiatan usahanya berdasarkan Prinsip Syariah dan membutuhkan SDM syariah yang memiliki keilmuan tentang konsep syariah. Penelitian ini bertujuan untuk melihat pengaruh minat, religiusitas dan prestasi belajar mahasiswa perbankan syariah terhadap kesiapan bekerja pada bank syariah. Penelitian ini mengunakan pendekatan kuantitatif dengan analisis regresi linear berganda dan teknik pengambilan sampel yaitu purposive sampling dengan responden sebanyak 81 dari 438 mahasiswa perbankan syariah. Hasil penelitian menunjukkan bahwa: Secara parsial minat bekerja, religiusitas dan prestasi belajar berpengaruh terhadap kesiapan bekerja pada bank syariah. Secara simultan minat bekerja, religiusitas dan prestasi belajar berpengaruh terhadap kesiapan bekerja pada bank syariah
Menos Educação Física, menos formação humana, menos educação integral
Authors: Molina Neto Vicente
Published: February 2023

Neste ensaio refletimos sobre um dos efeitos do Novo Ensino Médio [(NEM) (Lei federal nº 13.415/2017)] no Rio Grande do Sul. Em outras palavras, tratamos, especificamente, da extinção progressiva da Educação Física Escolar e das Ciências Humanas em geral na “Matriz Curricular Gaúcha” do Estado do Rio Grande do Sul (RS) concretizado na portaria SEDUC 350/2021 emitida pela Gestão Estadual no exercício do mandato de 2019–2022. Para cumprir com o objetivo efetivamos uma análise dos documentos relativos ao que denominamos contrarreforma curricular. Sugerimos ao final a revisão da normativa estadual que reduz a carga horária da Educação Física na Educação Básica, tarefa que coincide com posições afirmadas por entidades científicas nacionais.
A comprehensive examination of ACE2 receptor and prediction of spike glycoprotein and ACE2 interaction based on in silico analysis of ACE2 receptor
Authors: Aktaş Emre , Özgentürk Nehir Özdemir
Published: February 2023

ACE2 receptor plays a vital role not only in the SARS-CoV-induced
epidemic but also in some diseases. Studies have been carried out on the
interactions of ACE2- SARS-CoV proteins. However, comprehensive research
has not been conducted on ACE2 protein by using bioinformatic tools. The
present study especially two places, G104 and L108 points, which are
effective in protecting the structure of the ACE2 protein, play a
critical role in the biological functioning of this protein, and play an
essential role in determining the chemical-physical properties of this
protein, and play a crucial role for ACE2 protein-SARS CoV surface
glycoprotein, were determined. It was also found that the G104 and L108
regions were more prone to possible mutations or deletions than the
other ACE2 protein regions. Moreover, it was determined that all
possible mutations or deletions in these regions affect the
chemical-physical properties, biological functions, and structure of the
ACE2 protein. Having a negative GRAVY value, one transmembrane helix, a
significant molecular weight, a long-estimated half-life as well as most
having unstable are results of G104 and L108 points mutations or
deletions. Finally, it was determined that LQQNGSSVLS, which belongs to
the ACE2 protein, may play an active role in binding the spike protein
of SARS-CoV. All possible docking scores and results were estimated.
Based on the docking score, MD results are taken and It is seen that
mutation at G104 and L108 may affect the spike-ACE2 interaction. It is
thought that this study will bring a different perspective to ACE2
_SARS-CoV interaction and other diseases in which ACE2 plays an
important role and will also be an essential resource for studies on
ACE2 protein.
Mitochondrial genome assembly and comparative mitogenomics of five snake mackerels (Perciformes, Gempylidae).
Authors: Mthethwa Siphesihle , Merwe Aletta Bester-van der , Roodt-Wilding Rouvay
Published: February 2023

The Gempylidae (snake mackerels) family, belonging to the order
Perciformes, consists of about 24 species described in 16 genera
primarily distributed in tropical, subtropical, and temperate areas
worldwide. Despite substantial research on this family utilizing
morphological and molecular approaches, taxonomy categorization in this
group has remained puzzling for decades prompting the need for further
investigation into the underlying evolutionary history among the
gempylids using molecular tools. In this study, we characterized and
compared eight complete mitochondrial genomes for five Gempylidae
species [Neoepinnula minetomai, Neoepinnula orientalis, Rexea
antefurcata, Rexea prometheoides, and Thyrsites atun] using
Ion-Torrent sequencing. Using Bayesian Inference and Maximum-Likelihood
tree search methods, we investigated the evolutionary relationships of
seventeen Gempylidae species using mitogenome data. In addition, we
estimate divergence times for extant gempylids. We identified two major
clades that formed approximately 48.05 (35.89 – 52.04 mya) million
years ago; Gempylidae 1 [Lepidocybium flavobrunneum, Ruvettus
pretiosus, Neoepinnula minetomai, Neoepinnula orientalis, and Epinnula
magistralis], and Gempylidae 2 [Thyrsites atun, Promethichthys
prometheus, Nealotus tripes, Diplospinus multistriatus, Paradiplospinus
antarcticus, Rexea antefurcata, Rexea nakamurai, Rexea prometheoides,
Rexea solandri, Thyrsitoides marleyi, Gempylus serpens, and Nesiarchus
nasutus]. The present study demonstrates the superior performance of
complete mitogenome data compared to individual genes in phylogenetic
reconstruction. In addition to Cytochrome c oxidase subunit 1, NADH
dehydrogenase subunit 2, and Cytochrome b, which are frequently employed
in phylogenetic investigations, NADH dehydrogenase subunit 5 provided
adequate resolving power. Analyses of selection pressure revealed
purifying selection is predominant in Gempylidae mitogenomes. By
including T. atun individuals from different regions we demonstrate the
potential for the application of mitogenomes in species phylogeography.
Clinical and molecular features of LRBA.
Authors: Iyengar Vaishnavi , Taur Prasad , Gowri Vijaya , Chougule Akshaya , Prabhu Shakuntala , Bodhanwala Minnie , Madkaikar Manisha , Desai Mukesh
Published: February 2023

Background : Primary immune regulatory disorders (PIRD) is a new term
coined for a group of PID where autoimmune complications predominate.
Herein we present a case series of 10 cases with lipopolysaccharide
(LPS)-responsive and beige-like anchor protein (LRBA) deficiency who
presented with multiple autoimmunities. Methods: 10 patients with
molecular diagnosis of LRBA deficiency were included and their clinical
data was evaluated. Results: The mean age of onset was 4.3 years. Male
to female ratio was 7:3. 8/10 had 2 or more autoimmune disease with
autoimmune cytopenia being the commonest. Other autoimmune diseases seen
were autoimmune hepatitis, inflammatory bowel disease, enteropathy,
diabetes melitis, thyroiditis, CNS vasculitis, dermatitis and alopecia
areata. All patients had evidence of lymphoproliferation with
generalized lymphadenopathy and/or hepatosplenomegaly. 5/10 had
hypogammaglobinemia, 3/10 had low T cells, two of whom had CD4
lymphopenia. 4/10 had low B and NK cells. 2 had compound heterozygous
and 8 had homozygous mutations in LRBA gene. The treatment was diverse
and included corticosteroids, cyclosporine, azathioprine, cyclosporine,
rituximab, sirolimus and abatacept. One child has undergone successful
HSCT and currently doing well. Conclusion: Patients with LRBA deficiency
present with a broad range of clinical manifestations. High index of
suspicion for a monogenic cause for polyautoimmunity in early childhood
can reduce time delay in diagnosis. With increasing availability of
transplant facilities the outcome for these patients can be
significantly better.
Utilization of spent coffee grounds as fillers to prepare polypropylene composites for food packaging applications
Authors: Cai Yurong , Song Wenmin , Yang Yuncong , Cheng Xiuwen , Jiang Mingming , zhang Rui , Militky Jiri
Published: February 2023

Biomass-derived wastes as the additive of non-degradable plastics have
been paid more attention due to the ever-growing environmental pollution
and energy crisis. Herein, the spent coffee grounds (SCG) have been used
as fillers in polypropylene (PP) after the heat treatment to realize its
recycling utilization. The effect of the heat treatment atmosphere on
the properties of the obtained SCG and SCG/PP composites has been
investigated systematically. The results show that the residual coffee
oil can be removed more thoroughly under an air atmosphere than under a
nitrogen atmosphere at a relatively low cost and an eco-friendly
process. The lower residual oil rate of SCG is beneficial to improve the
comminution and further enhance the affinity with the PP matrix. The
obtained SCG/PP composite holds lower water absorption, higher
hydrophobicity, and better mechanical properties, implying its potential
applications in the field of food packaging.
Cellular redox state affects biofilm formation by a surfactin -dependent manner in Bacillus amyloliquefaciens?
Authors: Sun Huiwan , Si Fengmei , Zhao Xiuyun , Qi Gaofu
Published: February 2023

Surfactin is a signal to trigger biofilm formation against harsh
environments. Generally, harsh environments can result in change of the
cellular redox state to induce biofilm formation, but we know little
about whether the cellular redox state influences biofilm formation via
surfactin. Here, the reductant glucose could reduce surfactin and
enhance biofilm formation by a surfactin-independent way. The oxidant
H2O2 led to a decrease of surfactin accompanying with weakened biofilm
formation. Spx and PerR were both necessary for surfactin production and
biofilm formation. H2O2 improved surfactin production but inhibited
biofilm formation by a surfactin-independent manner in Δspx, while it
reduced surfactin production without obvious influence on biofilm
formation in ΔperR. The ability against H2O2 stress was enhanced in
Δspx, but weakened in ΔperR. Thereby, PerR was favorable for resisting
oxidative stress, while Spx played a negative role in this action.
Knockout and compensation of rex also supported that the cells could
form biofilm by a surfactin-independent way. Collectively, surfactin is
not a unique signal to trigger biofilm formation, and the cellular redox
state can influence biofilm formation by a surfactin- dependent or
independent way in B. amyloliquefaciens.
Primary scrotal Lipoma posing a diagnostic quandary: Experience from Northern Tanzania
Authors: Mbwambo Orgeness , Pallangyo Angela , Mbwambo Jasper , Bright Frank , Mteta Alfred , bogdawonicz Jacques , Ngowi Bartholomeo
Published: February 2023

Primary scrotal lipoma is a rare urological diagnosis. It is usually
diagnosed incidentally as most of time initial diagnosis may be confused
with other common etiology of scrotal masses. Here, we present a case a
rare case of scrotal lipoma with initial misdiagnosis of hydrocele at
primary health facility.
Effects of Typical Broad-leaved and Coniferous Forests on Water Quality in the Qinling Mountains, China
Authors: Zhang Shengli , Gao Xiaoxiao
Published: February 2023

Forests in the Qinling Mountains are an important source of fresh water
for 34.68 million people in China. However, heavy metal pollution and
acid rain have recently become common in this region. Forests can
improve water quality; however, a large amount of the Qinling Mountains
is covered by poor quality vegetation. This study investigated the
effects of Quercus aliena var . Acuteserrata (Qa),
Pinus tabulaeformis (Pt), Pinus armandii (Pa), and mixed
broad-leaved (Mb) tree stands on water quality in this region. The
results showed that the four stands increased the pH of slightly acidic
rainfall; this effect was more pronounced in broad-leaved stands than in
coniferous stands. As rainfall was converted to interflow, which is the
most important type of runoff in natural forest, the average SO
concentrations in broad-leaved
stands were higher in soil horizon A and lower in soil horizon B
compared to coniferous stands. As rainfall passed through the trees,
average NO concentrations
increased whereas NH decreased.
Compared to coniferous stands, NO
and NH concentrations in soil
horizon A interflow were higher in broad-leaved stands whereas NH
concentrations were lower in soil
horizon B. Average Cd and Pb concentrations decreased remarkably as
rainfall flowed through the stands. Broad-leaved stands led to greater
Cd reduction than coniferous stands. Furthermore, the Mb stand led to
the greatest reduction in Pb concentration. These results will be useful
for selecting the most appropriate tree species for afforestation in
[water-source](app:ds:forest%20for%20water%20resource%20conservation)
regions and in similar areas experiencing air pollution, specifically
heavy metal pollution.
Renal Dysfunction Determinants in Advanced Heart Failure Patients: Pulmonary Artery Catheterization Study
Authors: Demir Emre , Candemir Aytaç , Candemir Yeşim B. , Öztürk Rıza O. , Bilgehan * , Zoghi Mehdi , Gürgün Cemil , Nalbantgil Sanem
Published: February 2023

Introduction: Renal dysfunction in heart failure (HF) patients
is associated with poor outcomes. Reduced cardiac index (CI) and right
atrial pressure (RAP) are postulated to be a contributor the renal
dysfunction. This study aimed to investigate the relationship between
the estimated glomerular filtration rate (eGFR) and the pulmonary artery
catheterization (PAC) results. Patients and Method:
Hospitalized advanced HF patients, between 2016-2020 PAC performed
included in the study. Renal dysfunction was defined as
eGFR<60 ml/min/1.73 m . We evaluated the
correlation and the linear regression models of hemodynamics with eGFR.
Results: 181 patients were included in the study, and the mean
left ventricular ejection fraction (LVEF) was 20.9±3.7%, the mean eGFR
was 79.8±25.4 ml/min/1.73 m , and 22.7% of patients
had eGFR lower than 60 ml/min/1.73 m . CI (1.85±0.72;
1.84±0.64; p=0.47, respectively) and RAP (13.1±6.6; 13.7±6.8;
p=0.61,respectively) was not significantly associated with renal
dysfunction in HF patients. In the multivariable model, smoking history,
AF, body mass index (BMI) revealed negative relation with eGFR,
continuing ACEi or ARB therapy, and pulmonary artery capacitance
index(PAC-i) were positively related variables with eGFR
(p<0.0001). eGFR was not significantly different in distinct
tricuspid regurgitation severities (p=0.67); however, eGFR was
non-significantly higher in patients with moderate tricuspid
regurgitation. In patients with moderate tricuspid regurgitation, eGFR
had an inverse relationship with the RVSW-i and TRVP-i.
Conclusion: These results indicate that CI or RAP is not the
primary driver for eGFR. PAC-i and continuing ACEi or ARB positively,
AF, smoking history, and BMI were negatively related factors for reduced
eGFR.
Investigation of women’s access to cervical cancer screening during the Covid-19 pandemic: The case of Turkiye
Authors: GENCTURK Nuran , Özovalı Nilay Şener
Published: February 2023

Objectives: Covid-19, which affected countries all over the
world have disrupted health services and cancer screenings worldwide.
The study aimed to determine women’s access to cervical cancer screening
during the Covid-19 pandemic in Turkiye. Methods: The study was
planned as a descriptive cross-sectional. This study was composed of
women who have been sexually active. This study was completed with 443
people. The data were collected between 19 March and 27 April 2021 using
the “Data Collection Form” and the “Attitudes Towards Prevention of
Cervical Cancer Scale”. Results: More than half of the women
stated that Covid-19 and pandemic restrictions did not affect their
pap-smear. However, the Attitudes Towards Prevention of Cervical Cancer
Scale Cognitive and Affective mean scores of the women who stated that
the pandemic restrictions did not affect her getting pap-smear were
lower than the women who stated that it did. This situation shows that
the attitudes of women who stated that pandemic restrictions do not
affect their pap smears have low attitudes towards protection from
cervical cancer. Conclusions: It has been found that the
Covid-19 pandemic and the restrictions in accessing the health services
related to the pandemic have an impact on the attitudes towards
protection from cervical cancer, such as having a pap smear.
Relevance to clinical practice: Considering the unprecedented
effects of the pandemic around the world, in order to avoid its negative
effects on cancer screenings, health professionals working in public
health services should not delay cervical cancer screening tests.
Early prediction of breast cancer based on the classification of HER-2 and ER Biomarkers using Deep Neural Network
Authors: D Saranyaraj , M MANIKANDAN
Published: February 2023

Background: Due to the highly coarse chromatin,
multi-dimensionality of the histo image, irregularity of shape and size,
texture, and appearance, nuclei extraction is challenging. To address
these complexities, a deep learning algorithm called a stacked sparse
autoencoder had been considered a research factor in this paper.
Methods and Material: This paper focuses on detecting the
epithelial regions and extracting high-level features to segment the
patches based on the nuclei and classify the biomarkers concerning the
nuclei patches. We used 6,53,400 microscopic image patches of 363
patients sourced from the BreakHis database, of which 4,90,050 prominent
image patches containing only nuclei were utilized for Biomarker
classification (Basically eliminating the non-nuclei patches from 363
Whole slide Images (WSI)). The non-nuclei patches were eliminated due to
imbalanced class distribution. Results: The classifier finally
classifies if the nuclei detected based on the features are benign or
malignant, or normal with an accuracy of 99.73%, using which the early
prediction is performed by extracting and classifying the biomarkers
HER2 and ER. The overall classification rate of classifying HER-2 and ER
is 97.52%. Conclusion: The HER2 +ve was classified with
intensity above 23%, and Total nuclei in the range 150-1000 are termed
ER positive. Based on these 40 patients with HER2 +ve and 25 patients
with ER +ve were detected out of 363 patients. From the observation, it
is concluded that 25-40 patients are risked of breast cancer in the next
5 years due to the cell proliferation rate of 7000.
Association of rs4646903 and rs1048943 CYP1A1 estrogen-metabolizing gene polymorphisms with estrogen receptor-positive breast cancer in Kenyan women
Authors: Murithi Mary , Nyanjom Steven , Mobegi Victor , Shahin Sayed , Makokha Francis
Published: February 2023

Breast cancer is the most prevalent neoplasm and the second leading cause of death among females in Kenya. Estrogen and its metabolites are known risk factors for breast cancer. Polymorphisms in these genes and breast cancer susceptibility are unique among different populations. This study aimed to determine the probable associations between estrogen-metabolizing gene variations and other risk factors for breast cancer risk in Kenyan women. Buffy coat samples were obtained from patients diagnosed with estrogen receptor-positive breast cancer, benign breast disease, and healthy volunteers. Genotyping of target polymorphisms was conducted using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis. The rs4646903 variant genotype CC was associated with breast cancer in the case-control model (P=0.001); the heterozygous genotype TC (P=0.01) and the luminal B molecular subtype (P=0.02) showed increased odds of late-stage breast cancer. The rs1048943 variant genotype GG was associated with breast cancer in the case-benign model (P=0.04), whereas CG was associated with breast cancer in the case-control model (P=0.02). These findings imply that the rs4646903 and rs1048943 variant genotypes are involved in breast cancer risk in Kenyan women. Hence, they may be explored further as potential markers for the disease.
Self-assessment of resilience of future educators in crisis
Authors: Drljic Karmen
Published: February 2023

Future educators will face various challenges in their careers that will
require a resilient response, and the covid-19 epidemic is just one of many.
In this regard, we wanted to find out how students, future educators, assess
their own resilient protective factors, how those relate to each other and
which of them play a central role. The in-person survey involved 249
students who completed an anonymous questionnaire by self-assessing twelve
protective factors of resilience. We used the Pearson correlation
coefficient to determine the correlation between resilient factors and
establish a network of interconnectedness between them. The results revealed
that solution-focused behaviour (which is related to ability to identify
challenges) has a central role in students? resilience. We assumed that one
protective factor could contribute to the creation of new protective factors
(e. g. focused on identifying challenges correlates with focus on finding
solutions to them by using creative approaches, experiencing competence and
success and orientation towards lifelong learning). However, this assumption
should be further explored.
Fixation of an orthodontic anchor screw using beta-tricalcium phosphate in a screw-loosening model in rats
Authors: Nishioka-Sakamoto Kie , Hotokezaka Hitoshi , Hotokezaka Yuka , Nashiro Yukako , Funaki Mariko , Ohba Seigo , Yoshida Noriaki
Published: February 2023

Objectives

To create an orthodontic anchor screw (OAS)–loosening model and to investigate whether filling the bone hole with beta-tricalcium phosphate (β-TCP) can fix the OAS against orthodontic force.

Materials and Methods

Bone holes with different diameters (1.6, 2.1, or 2.5 mm) were drilled in the tibias of 11-week-old male Wistar rats, and an OAS (3.0 mm in length and 1.2 mm in diameter) was inserted. After a healing period of 2 or 4 weeks, orthodontic force was applied, and the diameter of the bone hole appropriate for the loosening model was determined. Subsequently, under the loosening model, the bone hole was filled with β-TCP, orthodontic force was applied, and movement of the OAS and surrounding tissue changes were evaluated by micro–computed tomography images and histological specimen analysis.

Results

The bone hole of 1.6 mm in diameter was employed as the OAS-loosening model. When β-TCP was inserted into the bone hole, the linear distance and mesial tipping angle of the OAS movement decreased markedly. Furthermore, the values of bone morphometry significantly increased with β-TCP filling.

Conclusions

An OAS-loosening model was established in rats and demonstrated that the loosening OAS was stabilized by β-TCP filling through bone formation. β-TCP may be useful for fixation of a loosening OAS.
Experimental Analysis of Effect to Friction of Commercial Oil Additive Used in Automobiles
Authors: ŞİMŞEK Mithat , SALMAN NTEZİYAREMYE Özlem , KALELİ Hakan , TUNAY Recai Fatih , DURAK Ertuğrul
Published: February 2023

With the development of automotive technology, long life, high power, and low fuel consumption performance are expected from the internal combustion engine. This study investigated the effects of commercial oil additives on friction under different experimental conditions. In order to examine the friction effect, the samples prepared from the piston ring and cylinder were tested with the Reciprocating Test Rig at different speeds and loads. Using additives in the commercial oil lubricant showed a little reduction under the lower load. When the applied load increased commercial oil showed better friction coefficient performance in the experimental study. As for the expected results, the friction coefficient reduced with increasing sliding speeds under all conditions. In general, it was found that the commercial oil supplement did not have much effect on reducing the coefficient of friction when all the results were evaluated under these experimental conditions
Net Sıfır Emisyon Hedefine Doğru Türkiye Kara Yolu ve Demir Yolu Taşımacılığının Enerji Modellemesi (2025-2050)
Authors: DÖNMEZÇELİK Onur , KOÇAK Emre , ÖRKCÜ H. Hasan
Published: February 2023

Ulaştırma sektöründe emisyonların azaltılması, Türkiye’nin 2053 net sıfır emisyon hedefinin en önemli adımlarından biri olacaktır. Bu hedefin en önemli parçası olacak elektrifikasyonun, özellikle karayolu ulaşım modlarında emisyonların azaltılmasında temel stratejiyi oluşturması beklenmektedir. Diğer birçok sektörden farklı olarak ulaştırma sektörü, maliyet minimizasyonunun yanı sıra davranışsal hareketlerden de etkilenmektedir. Bu nedenle politika yapıcılar ve tüketiciler arasındaki etkileşim çevre ve enerji ekseninde bir sistem analizini zorunlu kılmaktadır. Bu çalışma, Türkiye’nin 2025-2050 döneminde belirlediği net sıfır emisyon hedefi için ulaştırma sektöründeki enerji tüketiminin önemli bir payını oluşturan karayolu ve demiryolu taşımacılığının mevcut ve uygulanabilir politikalar altında nasıl konumlanabileceğine odaklanmaktadır. Bu amaçla tasarlanan Türkiye için Enerji Sistem Modeli (EST) kullanılarak senaryolar oluşturulmuştur. Net sıfır senaryosunda CO2 standartlarının uygulanması, içten yanmalı motor teknolojilerinde yeni girişlerin yasaklanması, ulaşım tercihlerinin karayolundan demiryoluna kaydırılması gibi politikalar, ulaştırma sektörünün net sıfır emisyon hedefine sağlayacağı katkının önemini ortaya çıkarmaktadır.
Restoring Language to Literature Pedagogy: Towards an Interactive Approach
Authors: Salim Mohammad Taher Hossain
Published: February 2023

English literature teaching in Bangladeshi universities has remained to be a frustrating experience for the faculties. This “frustration” is often attributed to the poor understanding of “the intellectually unequipped” and ‘linguistically unprepared’ students. This study, to understand the faculty frustration, investigates the literature teaching approaches practiced in the classes. The study also examines the role of “linguistic skill” as the learning outcome in the lesson plan of the course teachers. Finally, the paper finds that literature teaching at the tertiary level in Bangladesh does not accommodate pedagogical approaches and the linguistic skill of the students is not given the required priority in the teaching process. This paper, therefore, recommends an Interactive Approach in which language is to be integrated as one of the learning outcomes.
Identification of social innovations in e-learning education of students during the COVID-19 pandemic
Authors: Borowska Magdalena , Kołodziej Izabela
Published: February 2023

The article is theoretical and analytical in nature and aims to identify the manifestations of social innovations in e-learning education at the Wroclaw University of Economics and Business during the COVID-19 pandemic. The study focuses on the need for academics to use innovative (novel) distance learning tools. In addition, an attempt was made to assess the impact of selected tools on the development of new competencies among students. In order to achieve this goal, a proprietary online questionnaire was developed and free interviews were conducted with students. The survey was created in MS Forms application. A total of 151 students (second year) studying at the Faculty of Production Engineering of the Wroclaw University of Economics were surveyed. The survey period was in the summer semester 2020/2021. The study showed that the use of virtual tools contributed to the development of additional skills among students, such as teamwork and collaboration skills or creativity.
Interpretation of law as the content of interpretative activity: a general theoretical characteristic
Authors: Navrotska Yu. O.
Published: February 2023

The Paper provides a general theoretical description of the interpretation of law as the content of inter- pretive activity, in particular, its legal nature, essential features, reasons for use, and role in the mechanism of legal regulation are revealed.Attention was drawn to the fact that in every science commonly used terms can be filled with a new mean- ing, and the term “interpretation” in jurisprudence was used to denote a special type (form) of state-authority activity.The features of the main theories and legal schools formed in modern theoretical jurisprudence regarding the problems of legal interpretation are revealed, including hermeneutic, analytical, argumentative, origina- lism theory, target interpretation theory, as well as probabilistic. he conclusion that interpretation is a necessary element (attribute) of the general mechanism of legal regulation is substantiated; it is carried out both at the stage of formation of the regulatory and legal frame- work and at the stage of implementation of the law. Interpretation can be (and actually is) carried out by all subjects of law in the process of exercising their powers or rights and duties. Accordingly, the proper inter- pretation of the law is an important guarantee of the realization of subjective rights, freedoms and duties, a necessary prerequisite for legality and law and order.Attention is drawn to the fact that the law is a kind of social regulators, a system of certain norms, there- fore the interpretation of the law in the literal sense of the word means only the interpretation of the norms of the law, that is, the interpretation of those norms contained in the relevant sources (forms) of the law. When it concerns not only normative, but also other legal acts (law-enforcing, establishing-nominative, interpre- tive, then the name “legal interpretation” is more correct, and not interpretation of law. Interpretation of law should be understood as a type of legal interpretation, the object of which is there are exclusively legal norms, i.e. universally binding rules of conduct, designed for repeated implementation, regardless of the forms (sources) in which they are contained.
Lease contract of water objects: environmental and legal aspects and prospects for use
Authors: Sokolova A. , Cherkashina M.
Published: February 2023

It is emphasized that, despite social changes in the world, general processes and the importance of restoration, protection and conservation of the natural environment, there are acute problems of rational and effective use of natural resources and complexes in Ukraine. This does not fully correspond to the commonly recognized concept of the need to consider the interests of future generations and meet the contemporary needs of humanity. Based on this, it has been proven that there is an urgent need to provide the introduction of rational and effective use of natural resources and complexes, as well as to restore and preserve the latter, in order to correct the current situation, guarantee the realization of the environmental rights of every citizen of our country and the right to use natural resources in particular.

An analysis of the norms of the current domestic legislation, in particular, water and land legislation, whose prescriptions regulate relations with the use of natural objects, including water ones, was carried out. It is argued that one of the priority steps now should be the development of a special legal mechanism, for example, by spreading the practice of using objects under a lease contract. Based on the modern trends in the functioning and development of environmental law and its leading sub-branches - water and land, it is proved that when studying the contract for the lease of water (water objects), namely its legal nature, it is of great interest to clearly establish as its object, as well as essential features of the latter.

The ecological state of water objects on the territory of our country is characterized. It was found out that the main reason for the clear separation and legislative consolidation of the types of intended use when renting the mentioned objects is their functional purpose, since the components of the water ecosystem are interdependent and interconnected. It is proposed to bring in accordance with the provisions of the Water Code of Ukraine art. 59 of the Land Code of Ukraine, making changes to the list of types of targeted rental use. Proposals for improving the environmental (in particular, water and land) legislation of Ukraine regarding the legal basis of the water lease contract are substantiated.
The features of the mechanism of legal regulation of the creation and use of intellectual property objects in labor relations
Authors: Sova V.
Published: February 2023

The article is devoted to clarifying the characteristic features of the mechanism of legal regulation of the creation and use of intellectual property objects in labor relations. It is established that this mechanism is a multi-valued phenomenon, characterized by significant socio-legal significance and consisting of a system of mutually agreed-upon elements (legal instruments and methods of their application). The purpose of this regulatory structure is to create two critical conditions within the framework of normative activity. First, requirements for the proper emergence, flow, and termination of relations will be developed, with the purpose of labor law and intellectual property rights thoroughly objectified. Secondly, the creation of conditions under which the legitimate interests of the employee, employer, and society will be satisfied (in the context of the creation and/or use of intellectual property objects). The mechanism of legal regulation of the creation and use of intellectual property objects in labor relations is based on a special regulatory framework. This framework ensures that this mechanism operates in accordance with legal rules. At the same time, the effect of the mechanism under consideration is manifested only in the activities of the subjects of normative activity, the structure of which is determined by the levels of norm-making in the field of labor and employment (central, municipal, and local levels). This article argues that the legal regulation of the creation and use of intellectual property objects within labor relations incorporates the existing conflict of legitimate interests among various subjects. Mainly, this mechanism takes into account the conflict of legitimate interests between the employee and the employer. It also takes into account the conflict between the legitimate interests of the creator of the intellectual property object and society. In the conclusions to the article, it is noted that the signs of the mechanism of legal regulation of the creation and use of intellectual property objects in labor relations indicate that it is advisable to comprehend this phenomenon in two contexts: in the static aspect (as a system of legal instruments, methods, and methods of their application); in the dynamic aspect (as the process of using these tools in standard-setting activities).
Protection of rights of employees in case of employment contract’s suspension under the martial law
Authors: Gluschenko M.
Published: February 2023

The author focuses on the actual problems of implementing the employee's right to protection in case of the employment contract’s suspension in the conditions of martial law. Within the framework of the study, the author considers both theoretical and practical issues of the institute of suspension of employment relations. At the same time, the main attention is paid to the peculiarities of the suspension of employment contracts during the legal regime of martial law, as well as to the problems of implementing the right of employees to protection in case of violation of legal grounds for such suspension by employers. It is emphasized that for the legality of the suspension of the employment contract in the conditions of martial law, the simultaneous presence of several conditions is necessary, such as: 1) the fact of armed aggression and the existence of the legal regime of martial law; 2) absolute impossibility of providing work by the employer and performing work by the employee. At the same time, the lack of a relevant legal norm is the absence of a clear definition or at least signs of the impossibility of the parties to the employment contract fulfilling their obligations. It has been proven that the labour legislation should not only clearly state the conditions and procedure for suspending the employment contract, but also establish the employer's financial responsibility to the employee in the form of average earnings for forced absenteeism in the event that such suspension is recognized as illegal. In particular, in the case of the cancellation of the suspension of the employment contract by the court in connection with the employer's violation of the labor legislation when it was issued (for example, the suspension of the employment contract was introduced at the initiative of the employer without sufficient grounds for this), the implementation of the right to protect the violated rights of the employee should include not only the cancellation of the order and the restoration of the employment contract, but also the reimbursement by the employer of the average earnings during the period of forced absenteeism, by analogy with Article 235 of the Labor Code of Ukraine, according to the second part of which, when making a decision on reinstatement, the body that considers a labor dispute simultaneously takes decision to pay the employee the average salary for the period of forced absenteeism.