bluuebunny/crossref_metadata_2025 huggingface dataset:
Does the intentionality of mind wandering affect the combined dimensions of temporal orientation and emotional valence?
Authors: Guan Siqing , Takahashi Toru , Kumano Hiroaki
Published: February 2023

The intentionality and content dimensions of mind wandering (MW) are important determinants of its costs and benefits. However, the relationship of intentionality with various combinations of different content dimensions has never been examined. In this study, we aimed to examine whether the content of intentional and unintentional MW differs in terms of temporal orientation, emotional valence, and combinations of these two factors. Results indicated that intentional and unintentional MW did not differ in the frequency of negative valence, whereas a difference was observed in the frequency of negative valence combined with temporal orientation. Unintentional MW was 4.88 times more likely than intentional MW to generate negative past-oriented content, while intentional MW was 2.61 times more likely to generate negative future-oriented content. Furthermore, when compared to intentional MW, unintentional MW was 1.94 times more likely to generate neutral past-oriented content, while intentional MW was 2.17 times more likely to generate positive future-oriented content. These findings show that intentional and unintentional MW have different effects on the content generated, depending on whether the content dimensions are considered separately or combined, which opens crucial new perspectives on understanding the functionality of MW.
The Factors that Influence the Intention of Marketing and Technological Innovation in MSMEs
Authors: Wulandari Ririn , Koe Wei-Loon
Published: February 2023

Innovation drives change, and conversely, innovation occurs because of change. Initially, innovation was only oriented toward technology in discovering new products. Only large companies could do it since it requires a challenging process. All levels, including MSMEs, could carry out further developments and innovation because innovation is not only about technological innovations. Based on this, the research objectives are to analyze the influence of the MSME owner’s characteristics on the intention of marketing and technological innovation through attitude and motivation in Indonesia. SEM analysis with the Smart-PLS program was used to answer the research objectives. The population in this study is the Indonesian micro, small, and medium enterprises from various types of businesses. Samples are 128 respondents to meet Hair theory. The minimum threshold for processing by the Smart PLS program is 100. Judgment sampling is defined as the sampling technique. The results of this study are attitude and motivation affect innovation intentions, both directly and as intervening variables that encourage curiosity, optimism, and risk-taking. Opinion leadership, social status, attitudes, and motivation influence the intention of marketing innovation, whereas awareness, financial stability, optimism, risk-taking, attitudes, and motivation directly affect the intention of technological innovation. The findings of this study are useful for the government and social organizations as a companion for MSMEs to massively increase intention in innovation for MSMEs by creating activities that foster attitudes and motivation to innovate. With the massive formation of attitudes and motivation to innovate, several characteristics possessed by MSME owners are encouraged to strengthen, thus giving rise to the intention to innovate. The innovations carried out by MSMEs on a massive scale can improve their performance and become a solution to the downturn. These characteristics, attitudes, and motivations are the novelty of this research, which are the factors influencing the intention to innovate, both marketing and technological innovation.
On the Path to Decarbonisation
Authors: Stewart Andrew J.
Published: February 2023

Cement and concrete are the fundamental building materials of the modern built environment. Our cities grow to the sky and into the ground, all based on concrete and its key ingredient, cement. Concretes are changing, but the role of concrete in our world is not. At present, most concrete has significant embodied CO2, but there is growing focus on changing that.
Historic Concrete Science: Opus Caementicium to “Natural Cements”
Authors: Elsen Jan , Jackson Marie D. , Ruiz-Agudo Encarnación
Published: February 2023

The history of mineral components in cementitious materials begins with clays and bitumen in the most ancient mortars, followed by gypsum- and lime-based plasters, mortars, and concretes. Romans perfected the fabrication of extremely durable mortars that form the basis of audacious architectural monuments in Rome, massive harbor constructions, and water-proofed cisterns in the Mediterranean region. During the industrial revolution, “natural cements” were developed through the burning of impure limestone or Si- and Al-bearing materials blended with pure limestone. Delving into the past of concrete science and the composition, durability, and resilience of historic binders, mortars, and concretes can inspire the development of modern environmentally friendly cementitious materials.
Developing a public-private partnership framework for managing the adverse health effects of environmental disaster (a case study of Lake Urmia – Iran)
Authors: Gharaee Hojatolah , Dewey Rebecca Susan , Gholami Amir Hossein , Azami-Aghdash Saber
Published: February 2023

The present study aimed to develop a Public-Private Partnership framework for managing the Adverse Health Effects of Environmental Disasters using the drying lake Urmia case study in Iran. This is a qualitative study with grounded theoretical approach. Data were collected through semi-structured interviews and analyzed using content analysis. To formulate the initial framework, an expert panel was formed. Delphi methodology was used to determine the validity of framework. The most critical infrastructure for private sector participation was designing a legal framework and providing adequate resources and facilities. Pollutant assessment and public education are among the essential areas in which the private sector can participate. To evaluate the performance of the private sector, periodic and short-term reports, and documentation should be used. Payments to the private sector should be for periodic objectives based on performance. Reimbursement should combine service fees, allocation per capita, and performance quality. One of the significant difficulties and challenges in the managing of AHEEDs is lack of resources, poor management and inter-departmental coordination. Policymakers can consider PPP as an effective policy for reducing the AHEEDs. To this end, the framework presented in this study can be used as a guide by national and local authorities and policymakers.
Experiments and simulations of surface cleaning for a gas–liquid two-phase jet
Authors: Shi Feng-xia , Zhao Jian , Zhou Yi , Zhang Huan
Published: February 2023

In this study, a new cleaning method for the gas-mixed water jet is proposed. The pulsation characteristics of the gas -liquid two-phase jet and the influences of parameters on the cleaning effect were analyzed by performing simulations and experiments. The results showed that the impact pressure fluctuated and was much higher than the inlet pressure. With a continuous increase in the standoff distance, the impact pressure first decreased slowly and then decreased significantly, while the diameter and depth of the crater first increased and then decreased. The optimal standoff distance for a desirable impact effect was 10 mm. With the increase in gas concentration, the impact pressure became higher for gas concentrations of less than 8%, while the impact pressure decreased for the gas concentration of more than 8%. A higher impact pressure along with a fiercer jet pulsation resulted when the flow rate became larger. Accordingly, the diameter and depth of impact crater became enlarged. The impact pressure first increased and then decreased with the increase of nozzle contraction angle. Moreover, the optimal value of such an angle was 140°. This study provides fundamental and practical guidance to further improve the application of gas-mixed water jet cleaning technology.
Thermal activation, characterization and performance evaluation of Ethiopian bentonite for sodium removal
Authors: Musie Wondimu , Gonfa Girma
Published: February 2023

Bentonite is one of the clay materials that have important characteristics and is applicable to construction and for different industrial uses. Treatment of this material to enhance some of its physicochemical properties to suit the desired applicability has been a focus research area. In this work, natural bentonite from Warseisso, Afar region, Ethiopia was activated with thermal treatment. The raw and treated bentonites were then characterized using SEM, FTIR, XRD, BET, and cation exchange capacity. The effects of activation parameters (time and temperature) on its physiochemical properties and its performance for the removal of sodium ions from water were investigated. Bentonite activated for 6 h at 300 °C showed a maximum specific surface area of 81.74 m2/g while the raw one showed 57.6 m2/g. However, the cation exchange capacity value of the raw bentonite was found to be 82.1 meq/100 g while the value was reduced to 67.2 meq/100 g for treated bentonite with high specific surface area. To check the performance of the activated bentonite for desalination application, batch adsorption of sodium from synthetically produced sodium chloride solution was made. A sodium removal performance of 10% was achieved with treated bentonite at the maximum specific surface area.
Uluslararası Öğrencilerin Uyum Problemleri ve Bu Problemlerle Baş Etme Stratejileri: Bir Durum Çalışması
Authors: GÖNÜLTAŞ Mesut , KUL Aykut , AL-KHATİB Amal
Published: February 2023

Bu araştırmada, uluslararası öğrencilerin Covid-19 pandemisi sürecinde karşılaştıkları uyum problemlerini ve bu problemlerle baş etme stratejilerini ortaya koymak amaçlanmıştır. Nitel araştırma yöntemiyle yürütülen çalışmada durum çalışması deseni kullanılmıştır. Araştırmanın çalışma grubunu 2021-2022 akademik yılında Ege Üniversitesi’nde lisansüstü öğrenim gören altı uluslararası öğrenci oluşturmaktadır. Veri toplamada araştırmacılar tarafından geliştirilen yarı yapılandırılmış görüşme formu kullanılmış ve elde edilen verilerin çözümlenmesinde içerik analizi yönteminden yararlanılmıştır. Yapılan analizler sonucunda uluslararası öğrencilerin uyum sürecini zorlaştıran başlıca problemlerin iletişim sorunları ile pandemi döneminin olumsuz etkileri olduğu ortaya çıkmıştır. Pandemi dönemi kısıtlamaları öğrencilerin barınma sorunları, ekonomik ve akademik problemler yaşamasına yol açmıştır. Bunun yanında sosyo-kültürel farklılıkların yol açtığı sorunlar ile duygusal sorunlar öğrencilerin yaşadığı dikkat çeken diğer sorunlar olmuştur. Uluslararası öğrenciler iletişim problemlerinin çözümü için dil öğrenme, pandeminin olumsuz etkilerini azaltmak için kısıtlamalarına uyma yoluna gitmiştir. Sosyo-kültürel sorunlarla baş etmede arkadaşlık ilişkilerini geliştirme ve Türk kültürünü tanımaya çalışmak; akademik sorunlarla baş etmede ders çalışmaya daha çok vakit ayırmak ve eğitimlere katılmak; duygusal problemler ile baş etmede ise arkadaş edinmek ve aile ile konuşmak uluslararası öğrencilerin kullandığı stratejiler olmuştur.
Madde ve Doğası Konusu Öğretiminde Kullanılan Yöntemlerin Etkililiğinin İncelenmesi: Meta Analiz Çalışması
Authors: GÖKTÜRK Özge , KANADLI Sedat
Published: February 2023

Bu çalışmanın amacı madde ve doğası konu alanının öğretiminde kullanılan en yaygın yöntem ve yaklaşımların akademik başarı üzerindeki inceleyerek belirleyerek etki büyüklüğü en fazla olan yöntem ve yaklaşımı belirlemektir. Bu amaçla 2000-2020 yılları arasında Türkiye’de yürütülmüş ve içerme ölçütlerini karşılayan 38 deneysel çalışma meta-analiz yöntemiyle incelenmiştir. Bireysel çalışmaların etki büyüklükleri için Hedges g indeksi kullanılmıştır. Genel etki büyüklüğünü hesaplamak için bireysel çalışmaların etki büyüklükleri rastgele etkiler modeli ile birleştirilmiştir. Yapılan meta-analiz sonucunda genel etki büyüklüğünün orta düzeyde (g=0.754) ve anlamlı (p
Socio-economic consequences of bankruptcy of individuals
Authors: Davydenko Vladimir A. , Danilova Elena P. , Portnyaga Ekaterina M.
Published: February 2023

The bankruptcy of individuals has become especially relevant. This is confirmed by numerous commercials about bankruptcy on the Internet and on television, which were practically non-existent before. This article discusses the causes and consequences of bankruptcy of individuals. First of all, this process affects the debtor and the creditor, but it indirectly affects the country as a whole. The authors studied the world experience on the problem of bankruptcy of individuals and conducted a comparative analysis for different countries, conducted and transcribed in-depth interviews with lawyers and arbitration managers, conducted a questionnaire among citizens who entered bankruptcy proceedings, and compiled a “portrait of the average debtor”. The authors pointed out the pressing problems faced by citizens and creditors in the bankruptcy process, described the reasons why people enter bankruptcy, showed how economic sanctions and the COVID-19 pandemic affected the growth of bankruptcy, demonstrated the dynamics of bankruptcy of individuals in Russia and in foreign countries, gave a forecast of possible developments related to with the bankruptcy of individuals. The novelty of the article and the author’s contribution consists in the introduction into scientific circulation of the definition “leniency”, which reflects the real economic, sociological and legal situation in a particular country on key grounds — such as the presence of direct bankruptcy; its acceptability; prices (costs); complexity; dynamics of the process; conditions and possibilities of debt repayment during its restructuring; real problems of bankruptcy stigmatization.
Technique of numerical simulation of wave processes in a heterogeneous hydrate-containing porous medium
Authors: Gubaidullin Amir A. , Boldyreva Olga Yu. , Dudko Dina N.
Published: February 2023

A technique for numerical simulation of wave propagation in a hydrate-containing porous medium consisting of layers with different properties is proposed. The method is based on a mathematical model previously developed by the authors, which considers the difference between the velocities and pressures of the skeleton and fluid, and the McCormack finite difference method. A computer implementation of the model was performed, and preliminary calculations were carried out, which showed the efficiency of the proposed methodology. The possibility of applying this approach to the numerical solution of the problem of propagation and reflection of pressure waves in a layered hydrate-containing porous medium is shown.
Reversible Complete Heart Block in a Pregnant Woman Responding to
Steroids: A rare Case Report
Authors: Mahadevappa Manjappa , Patil Soumya , Tripathi Rishi , Ajjammanavar Virupaksha , Kulkarni Prashanth
Published: February 2023

Background:

Complete heart block (CHB) is the total absence of conduction from atria to ventricles with an escape rhythm most commonly arising from the AVN or His bundle. CHB in pregnancy is very rare, and most reported cases are due to congenital variety, where the pre-existing CHB from birth is either detected incidentally or presented with symptoms during pregnancy. Pregnancy is associated with various physiological changes, such as a pro-inflammatory, hypercoagulable state with possible oedema of the heart's conduction system, which may rarely give rise to CHB. There are no clear guidelines to manage CHB complicating pregnancy.

Case Presentation::

An asymptomatic 27-year-old lady with G2P1L1, 39 weeks of gestation with breech presentation, was referred for delivery given the low maternal heart rate of 40 bpm. Per abdominal examination revealed a term size uterus with active contractions and a fetal heart rate of 140bpm. An ECG revealed a CHB with an escape rate of 40 bpm. Other routine investigations were normal, with negative serological evaluation for hepatitis B, C, and HIV. ANA and Anti-Ro ⁄ SSA antibodies. She underwent an emergency LSCS under spinal anaesthesia with a backup temporary pacemaker (TPM). She received a short course of empirical steroid therapy for three days as there were no obvious secondary causes for CHB, which reverted to sinus rhythm after 48 hours.

Discussion:

CHB complicating pregnancy with or without symptoms may require definitive therapy in the form of permanent pacemaker implantation. However, the insertion of a TPM for managing pregnancy is controversial as opinion in the literature is divided. There are no reports of CHB occurring in pregnancy without congenital or other known acquired causes. In the reported case, the CHB reverted to sinus rhythm with a short course of IV steroid therapy without any subsequent need for a PPM implantation.

Conclusion:

Congenital CHB remains the most common cause of rarely seen CHB complicating pregnancy. Through the conduction system oedema and inflammation, physiological changes in gestation may rarely cause CHB during pregnancy. In the absence of congenital CHB and other demonstrable acquired causes, a short course of steroid therapy may reverse the CHB avoiding PPM implantation as shown in the reported case.
Mechanisms, Copper Catalysts, and Ligands Involved in the Synthesis of 1,2,3-
Triazoles Using Click Chemistry
Authors: Leyva Elisa , Rubén Rodríguez-Gutiérrez Irving , Moctezuma Edgar , Noriega Saúl
Published: February 2023

In the last two decades, click chemistry has become a modular synthetic procedure
to assemble new molecular structures. It is a powerful methodology that relies on the construction
of carbon-heteroatom bonds of a variety of reactants. In modern synthetic chemistry, it has
been applied in a large number of applications, from pharmaceutical to material science. The
copper-catalyzed 1,2,3-triazole preparation, reacting organic azides with alkynes, has become
the star of click chemistry due to its reliability and biocompatibility. As a consequence, this
reaction has found many applications in diverse areas such as bioconjugation, material science,
and drug discovery. In order to understand the effect of copper catalysts and ligands in click
chemistry, it is important to understand the structural and mechanistic aspects involved. In this
review, several physicochemical aspects of click chemistry are discussed. First, the mechanisms
and intermediates involved in the preparation of 1,2,3-triazoles. Second, the different types of copper catalysts
are used to perform the reaction regioselectively. The last section shows the structure and characteristics of
effective ligands utilized to improve click chemistry under different experimental conditions.
Management of Hemorrhagic Fever Viruses: Intervention of Natural and
Synthetic Products
Authors: Lashgari Naser-Aldin , Roudsari Nazanin Momeni , Khayatan Danial , Samani Nasrin , Eskandari Rad Neda , Mortazavi Morteza , Abdolghaffari Amir Hossein , Momtaz Saeideh
Published: February 2023

Background:

Viral hemorrhagic fevers (VHFs) are a group of clinical syndromes caused by
several different RNA virus families, including several members of the arenavirus, bunyavirus, filovirus,
and flavivirus families. VHFs have high mortality rates, and they have been associated with vascular
permeability, malaise, fever, variable degrees of hemorrhage, reduced plasma volume, and coagulation
abnormalities. To treat such conditions, antigen-presenting cells target dysregulated immune reactions and
productive infections. Monocytes and macrophages produce inflammatory cytokines that damage adaptive
immunity, while infected dendritic cells fail to mature correctly, compromising adaptive immunity. Inflammation
and uncontrolled virus replication are associated with vascular leakage and coagulopathy.

Objective:

VHF infects both humans and animals and if not treated, causes hemorrhagic manifestations
and lethal platelet dysfunction. Besides pharmacological and immunological solutions, the intervention
of natural products for VHF management is of great interest. In this review, we gathered current
data about the effectiveness of natural products for VHF management.

Methods:

Data were extracted from Scopus, Google Scholar, PubMed, and Cochrane library in terms
of clinical and animal studies published in English between 1981 to February 2022.

Results:

Several plants from diverse families and species were identified with antiviral activity against
VHF. The combination of botanical therapeutics and multitarget synergistic therapeutic effects is now
the widely accepted explanation for the treatment of VHF. Most of these herbal therapeutics have
shown promising immunomodulatory effects in vivo and in vitro VHF models. They can probably
modulate the immune system in VHF-infected subjects mainly by interfering with certain inflammatory
mediators involved in various infectious diseases.

Conclusion:

Natural, in particular, herbal sources can be valuable for the management of various
VHFs and their related complications.
Survival of Persons Living With HIV/AIDS: A Multicentric Study From
India
Authors: Sinha Sanjeev , Abdul  Samad Sameer , Bansal Garima , Verma Saurav , Sangle Shashikala Anant , Guha Subhasish Kamal , Rajput Neetu , Pandey Ravindra Mohan , Ranjan Sanjay , Salvi Sonali , Mundhe Sanjay , More Monika , Modak Dolanchampa , Datta Kalpana , Kabra S.K. , Lodha Rakesh , Nischal Neeraj , Das Bimal Kumar
Published: February 2023

Background:

It has been more than 17 years since the introduction of free ART in India.
At this point, it would be prudent to look at the factors associated with the survival of persons living
with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLHA)
who are already enrolled in the ART program.

Methods:

PLHAs enrolled from antiretroviral therapy (ART) centers located in three different cities
in India – Delhi, Pune and Kolkata, and were followed up at six monthly intervals monitoring the
WHO stage, CD4 counts, complete blood counts, and liver and kidney function tests, for a duration
of three years.

objective:

Monitoring the WHO stage, CD4 counts, complete blood counts and liver and kidney function tests, for a duration of three years

Results and Discussion:

The incidence of mortality among HIV/AIDS patients on ART was 5·0 per
1000 patient-years (21/1410, 1.4%). Age at initiation of ART, being above 35 years, was the only
significant predictor of mortality (log-rank p = 0·018). Multivariable analysis showed a significant
association of an unfavourable outcome (defined as mortality or development of opportunistic infection
during follow-up) with male gender (adjusted odds ratio (AOR) = 5.26, p = <0.01) and being
unmarried at ART initiation (AOR = 1.39, p = 0.005).

Conclusion:

The survival of PLHA with good adherence to ART is independent of the WHO stage
or CD4 counts at the initiation of ART. Initiation of ART after 35 years of age was a significant
predictor of mortality.

conclusion:

The survival of PLHA with good adherence to ART is independent of the WHO stage or CD4 counts at initiation of ART.
Synthesis Memantine and Memantine Hydrochloride by Direct Amination
of 1-Bromo-3,5-dimethyladamantane with Thiourea
Authors: Vu Binh Duong , Phan Dinh Chau , Nguyen Thi Hong Tham , Nguyen Thi Hong Thanh , Luong Quang Anh , Ngo Thi Xuan Thu
Published: February 2023

Memantine hydrochloride (MH) is a first-line therapeutic drug approved by the US FDA
for the management of moderate to severe Alzheimer's disease. This study involves the synthesis of
memantine hydrochloride from 1-bromo-3,5-dimethyladamantane through a reaction with thiourea.
The research results showed that the solvent reaction was propylene glycol (PG); the total time reaction
was 5.5 hours, the temperature reaction in the first stage was 160oC and in the second stage was
80oC; the overall yield was 82.44%. The reaction intermediates were confirmed by the IR, MS,1HNMR,
and 13C-NMR spectra.
Recommendation to Consume Plant Products for their Health Benefits
may Take a Different Perspective with Global Warming
Authors: Sak Katrin
Published: February 2023

Over the past few decades, the multifaceted anticancer action of various plant-derived
flavonoids has been demonstrated both in in vitro and in vivo preclinical experiments as well as
in clinical trials and large-scale epidemiological studies. These secondary metabolites, synthesized
in plants in response to different environmental stresses, can exert diverse biological activities
in the human body after ingestion of plant-based foods. Flavonoids are indeed well-known
for their antioxidant, anti-inflammatory, antiproliferative, proapoptotic, anti-migratory, antiinvasive,
anti-metastatic, and anti-angiogenic properties, thereby preventing and slowing the development
of different types of human cancers. Accordingly, more and more people all over the
world have increased their everyday intake of fruits, vegetables, whole grains, and spices to get
the benefits of flavonoids. In this commentary article, a critical view is presented on the possible
gradual decrease in the health-promoting effects of edible and medicinal plant products related to
changes in their flavonoid content and composition as a consequence of global warming. It is indeed
generally accepted that biosynthesis and accumulation of certain flavonoids can be higher
in plants cultivated in colder conditions, while a high temperature may even block the production
of these agents. It only remains to be determined in the future as to what extent the lowering of
flavonoids content in plant-based diets during global warming can contribute to continuously increasing
worldwide incidence of new cancer cases, revealing the actual costs of human-induced
environmental changes.
Maternal, Fetal and Neonatal Outcomes in Pregnant Women with
COVID-19: A Case-Control Study
Authors: Sattari Mahtab , Samari Banafshe , Beheshti Rezvanehsadat , Farhadian Maryam , Tiznobaik Azita , Sepahvand Saba
Published: February 2023

Background:

COVID-19 is an emerging, highly contagious disease caused by the SARSCoV-
2 virus. Pregnant women appear to be at greater risk for COVID-19 infection and complications.
Considering the importance of maternal and fetal healthcare, this study aims to evaluate some of the
maternal, fetal, and neonatal outcomes in pregnant women with COVID-19.

Methods:

Pregnant women at the gestational age of 20 weeks or more were recruited and divided into
two groups: cases (those with COVID-19 infection) and controls (those without the infection). Maternal
complications during the current pregnancy, delivery factors, and fetal/neonatal complications
were recorded and compared between the groups.

Results:

Maternal COVID-19 infection was highly associated with the need for emergency cesarean
surgery (p = 0.005), preterm labor (p = 0.017), and the need for NICU admission for newborns (OR =
0.05, p = 0.000). Also, high rates of vertical transmission of the infection were observed in the cases.

Conclusion:

Maternal COVID-19 disease could be associated with a range of complications for both
the mother and her newborn. The vertical transmission rate was also observed to be higher than previously
reported in the literature. Further studies are required to evaluate this phenomenon.
Design, Synthesis, Molecular Docking, and Preliminary Pharmacological
Screening of some New Benzo[d]thiazol-2-ylamino Containing Chromen-2-
one Derivatives with Atypical Antipsychotic Profile
Authors: Gawai Ashish A. , Biyani Kailash R. , Das Sanjib , Tapadiya Ganesh G. , Mokale Santosh N. , Dhawale Sachin A.
Published: February 2023

Introduction:

Mental disorders are very serious complicated disorders. Schizophrenia
is one of the most baffling mental disorders. The new series 7-(2-(benzo[d]thiazol-2-
ylamino)ethoxy)-4-methyl-2H-chromen-2- synthesized in search of newer compounds for Schizophrenia.

Methods:

Synthesis is done by refluxing in dry pyridine with various substituted 2-amino benzothiazoles
derivatives (3a-3k) and 7-(2-Chloroethoxy)-4-methyl-2H-chromen-2-one (2). The molecular
docking approach was used to screen these generated derivatives. Chem Bio Draw Ultra 12
was used to draw the compounds, which were then exposed to all potential conformations of compounds
interacting with receptors. The Glide 7.6, Schrodinger 2017 Maestro 11.3 was used to
achieve molecular docking. The Dopamine receptor 6CM4 serotonin 5TUD PDBs were acquired
from the database of Brookhaven Protein. Using the OPLS 2005 force field, the ligand-protein
hydrogen-bond network was acquired, along with the overall energy reduced. A glide score was
used to rate the docking poses.

Results:

The produced compounds have been identified with the use of analytical and spectral
data. All of the produced substances were tested and analyzed for serotonin 5HT2 antagonistic and
dopamine D2 activity, which can be considered as a measure of typical antipsychotic properties.

Conclusion:

Compounds 4b, 4c, 4e, 4g & 4i have demonstrated promising pharmacological action
in preliminary studies. According to the preceding findings, compounds with electronwithdrawing
substitutions, such as 4e & 4b, have a good atypical profile of antipsychotics.
Yellow Fever Vaccination in Hemodialysis Patients: A Systematic Review
Authors: Figueiredo Vidal Emery Ciana , da Veiga Glaucia Luciano , Rodrigues Bacci Marcelo , Figueiredo Vidal Eglidia Carla , da Costa Aguiar Alves Beatriz , Gascon Thais , Affonso Fonseca Fernando Luiz
Published: February 2023

Introduction:

Yellow fever is an infectious disease endemic to Africa, and Central and
South America with a significant impact on public health, causing outbreaks and epidemics. Clinical
manifestations can vary from asymptomatic to more severe and lethal disease outcomes. The primary
prevention of yellow fever occurs through the vaccination of individuals, which confers immunity for
life. Patients with chronic kidney disease, especially those undergoing dialysis, have low vaccination
and seroconversion rates. As mentioned above, this research aimed to perform a systematic review of
the yellow fever vaccination protocol in hemodialysis patients.

Methods:

A systematic review on vaccination against yellow fever in hemodialysis patients using databases,
PubMed and Biblioteca Virtual em Saúde (BVS), was performed. For data collection, combinations
were made using the following descriptors: protocols, vaccination, yellow fever, kidney dialysis,
chronic kidney failure, chronic kidney disease, and group risk included in the title and abstract description.
Articles with no subject related to the search were excluded and also if they were duplicated.

Results:

In this review, 90 scientific articles were identified in both databases. After applying exclusion
criteria, a total of 3 articles were selected.

Conclusion:

We recommend carefully assessing the risk-benefit and contraindications for the patient,
emphasizing the risk groups. There is an evident lack of studies on the subject, and there is a need to
broaden investigations related toimmunization for patients on dialysis. The review is registered in the
PROSPERO system with the number 323550.
Optimization of Hormonal Compositions of Media for In vitro Propagation of Apple (Malus ×domestica Borkh.) Cultivars
Authors: Abdella Bona , Yusuf Zekeria , Petros Yohannes
Published: February 2023

Background:

Apple (Malus × domestica Borkh.) is one of the most important fruit crops in the world. Traditionally, vegetative propagation methods (including cutting, budding, and layering) are time-consuming (about three years), with low production rates and low success in obtaining virus-free plants.

Objective:

The present study was planned to investigate the in vitro propagation of apple (M. domestica) cultivars from nodal segments.

Methodology:

The Murashige and Skoog (MS) medium supplemented with sucrose and different concentrations of plant growth regulators (PGRs) were used for shoot proliferation and root induction. The optimal concentrations of PGRs in the MS medium were assessed. The effect of full and half-strength MS medium on root induction was investigated.

Results:

Examination of the effects of MS medium supplemented with various concentrations of indole-3-acetic acid (IAA) and kinetin revealed that the significantly highest shoot response was recorded for the ‘Princess’ cultivar with maximum shoot proliferation rate (65.25%), shoot number per explant (2.57), shoot length (7.28cm), and leaf number per shoot (6.15) after four weeks of culture. The root induction in micro shoots of three apple cultivars was observed after 20 days of culturing. The strength MS medium (full and half) containing 1.5 mg/L IAA significantly affected (at P<0.05, chi-square test) root induction in all three apple cultivars, especially rooting rate. However, there was no significant difference in root number and root length per micro shoot among the apple cultivars. Among the cultivars, significantly the highest rooting rate(48.30%), root number (6.25), and root length (4.15cm) were recorded for cultivar ‘Princess’ on full-strength MS medium.

Conclusion:

PGR combination of IAA (1.0 mg/L) and kinetin (3.0 mg/L) was found to be the best for shoot proliferation. The shoot responses were found to increase with an increase in kinetin concentration combined with IAA at 1.00 mg/L.
Compressive Strength Dependency on the Effect of Temperature Variation on the Percentages of Steel Fiber in Concrete
Authors: Emiri Dafe Aniekan , Chiadighikaobi Paschal Chimeremeze , Ng’andu Prosper
Published: February 2023

Aims:

The aim of this study is to check the effectiveness of steel fiber on the compressive strength of concrete.

Background:

Fibers have long been used as building materials to improve the ductility, tensile, compressive, and flexural strengths of concrete. Although fibers have been known as an effective reinforcement material for concrete structures, it is also acknowledged to be a suitable alternative to reinforcement steel bars.

Objective:

The objective of this research is to investigate some engineering properties, the compressive behavior of steel fiber reinforced concrete (SFRC), and the effect of elevated temperatures of up to 1000°C on concrete.

Methods:

Various tests which included the slump test, compressive strength test, as well as heating tests were done. The workability (slump) and thermal effects of M20 SFRC were evaluated.

Results:

Based on the results obtained, it could be observed that the workability of the M20 concrete reduced with the increase in steel fiber (SF) content from 0% to 1.6% as values obtained were 80mm, 73mm, 67mm, 61mm and 55mm for SF contents of 0%, 0.4%, 0.8%, 1.2%, and 1.6% respectively. These values showed medium workability of the concrete according to ASTM C-143/C-143 M-03. Also, the addition of SF to plain M20 concrete greatly improved the compressive strength (ƒc) with the concrete strength at 26.89N/mm2, 30.41N/mm2, 32.85N/mm2, 35.90N/mm2 and 39.66N/mm2 after 28 days of curing for steel fiber contents of 0%, 0.4%, 0.8%, 1.2%, and 1.6% respectively. The f_c after heating the concrete mix to 1,000°C showed improved thermal resistance with 4.2N/mm2, 8.23N/mm2, 11.63N/mm2, 15.60N/mm2 and 17.20N/mm2 for SF contents of 0%, 0.4%, 0.8%, 1.2% and 1.6% respectively.

Conclusion:

The incorporation of steel fibers in the concrete mix decreased the workability of SFRC but increased its compressive strength and balling tendencies.
Bioactive Furanocoumarin 'Alloimperatorin': Therapeutic Importance and
Pharmacological Activities in Medicine
Authors: Patel Dinesh Kumar
Published: February 2023

Background:

Plants and their derived phytochemicals commonly called secondary metabolites have been used in medicine as a good source of medicine for the treatment of numerous kinds of human disorders and associated complications. Herbal medicines have been used in modern medicine for the treatment of some chronic disorders, including cancer. Coumarins class phytochemicals are important in medicine and mainly derived from plant sources, including Angiosperms. Coumarins have numerous biological activities including antimicrobial, antibacterial, antifungal, antioxidant, antitumor, anti-HIV, antihypertension, anticoagulant, anticancer, antiviral, anti-inflammatory, analgesics, antidiabetic, and anti-depressive.

Methods:

Here in the present work, numerous scientific data were collected from different scientific databases and analyzed in order to know the biological potential of alloimperatorin in medicine. Google, Google Scholar, PubMed, and Scopus databases were searched and analyzed to know the medicinal properties and therapeutic potential of alloimperatorin. Therapeutic potential of alloimperatorin was investigated in the present work through scientific data analysis of different scientific research work. Pharmacological activities of alloimperatorin were analyzed in the present work to know the beneficial health aspects of alloimperatorin against various forms of human disorders.

Results:

Scientific data analysis of different research work revealed the therapeutic potential of alloimperatorin in medicine. Alloimperatorin is a coumarin class phytochemical found in the Angelica dahurica. Alloimperatorin revealed significant therapeutic potential in medicine mainly due to its anti-oxidative, anti-inflammatory, anti-apoptotic potential, however its biological potential in breast cancer and their photosensitization effect were also discussed in the present work. Analytical data signified the presence of alloimperatorin in different medicinal plants.

Conclusion:

Present work signified the biological importance and therapeutic potential of alloimperatorin in medicine.
Exploring Palmitoylated Arabinogalactan in Solid Lipid Nanoparticles: Formulation Design and in vitro Assessment for Hepatospecific Targeting
Authors: Shah Neelam , Katawale Saurabh , Shah Sanket , Dhawan Vivek , Nagarsenker Mangal
Published: February 2023

Aim:

The present study evaluates the feasibility of the incorporation of palmitoylated arabinogalactan in solid lipid nanoparticles and its potential as a hepatospecific targeting ligand.

Background:

Human hepatocellular carcinoma (HCC) is a neoplasm presenting low survival and higher incidence, due to difficulties in the treatment modalities to effectively place cancer therapeu-tics at the site. Targeting asialoglycoprotein receptors on the surface of hepatocytes employing lipid nanoparticles, and liposomes presents opportunities for improvement in therapy.

Objective:

The objective of the present investigation was to fabricate and evaluate the potential of palmitoylated arabinogalactan (PAG) incorporated SLNs to target asialoglycoprotein receptors.

Methods:

Daunorubicin-loaded targeted SLNs prepared by ultrasound dispersion method were evaluated for in vitro release and in vitro cytotoxicity. Lipids, surfactants, and biocompatible sol-vents were screened for SLN formation and optimization was done using 22 factorial designs.

Results:

The particle size for formulations was below 200 nm with a unimodal distribution. Differ-ential scanning calorimetry analysis revealed the interaction of lipids with other components charac-terized by a shift in lipid melting endotherm. Daunorubicin-loaded PAG SLNs released a signifi-cantly higher amount of daunorubicin at pH 5.5 as compared to pH 7.4, providing an advantage for targeted tumor therapy. In vitro cytotoxicity studies showed that daunorubicin depicted a dose-dependent reduction in viability in all cell lines treated with formulation as well as free drug.

Conclusion:

SLNs showed enhancement in intracellular uptake of daunorubicin thereby establish-ing their potential in improved treatment of HCC and warrant further in vivo investigations.
An Overview of Recent Patents and Future Perspective Based on Cyclodextrin
Complexation
Authors: Kaushik Ritu , Verma Ravinder , Budhwar Vikas , Kaushik Deepak
Published: February 2023

The majority of drugs taken orally have limited aqueous solubility and dissolution rate. Cyclodextrin
(CD) and its derivatives are used as pharmaceutical adjuvants, contributing to the development
of safe and high bioavailability formulations. CDs have a unique structure with a variety of
physicochemical features that aid pharmaceutical scientists in solving drug delivery issues for poorly
water-soluble drugs (PWS). This article covers information about cyclodextrin and its various derivatives,
its different manufacturing process, physicochemical properties, advantages, and recent advancements.
There are various advantages of CD-based inclusion complexes, such as enhancement of
solubility, bioavailability, and stability and reduction of irritation caused by the drug. Moreover, they
are used as odor and taste enhancers and also prevent incompatibility by physically isolating the incompatible
drug components in drug formulation. CD and its derivatives are extensively employed as
solubilizers in the manufacturing of parenteral and oral dosage forms. Inclusion complexes formed by
CDs with appropriately sized guest molecules improve drug water solubility, physical-chemical stability,
and bioavailability. Simultaneously CDs prevent the drugs from degradation like oxidation, hydrolysis,
and photodegradation and extend the shelf life of the drug. The manuscript also highlights
patents and exclusive branded formulations of modified CDs. It also discusses the different examples
of chemically modified CDs, i.e., captisol, sulfobutyl ether-β-CD, hydroxy propyl betadex, randomly
methylated β-CD, methyl β-CD, and hydoxy propyl γ-CD, all are used in the various dosage forms.
2022 WEST COAST SECURITY CONFERENCE WELCOMING REMARKS
Authors: Kelshall Candyce
Published: February 2023

On November 21, 2022, Candyce Kelshall, President of the Canadian Association for Security and Intelligence Studies Vancouver, delivered her welcome remarks for the 2022 West Coast Security Conference. During her welcoming remarks she stated that the conference was designed for Canada, its military, law enforcement, and the public safety community. Kelshall spoke about the importance of the public safety community considering the emergence of new threat actors and new technologies, changing from state-based responses to identity-based responses when assessing new threats, adapting to changing norms, and collaborating beyond boundaries.  
 
Received: 2022-12-27Revised: 2022-12-27
MENTAL HEALTH AND WELLBEING IN THE POLICE AND EMERGENCY SERVICES SECTOR
Authors: Lawrence David
Published: February 2023

On November 23, 2022, David Lawrence, Professor of Mental Health in the School of Population Health at Curtin University & Adjunct Professor in the School of Population and Global Health at the University of Western Australia, presented on Mental Health and Wellbeing in the Police and Emergency Services Sector. Following the presentation, a question-and-answer period ensued with questions from the audience and CASIS Vancouver executives. The key points discussed were experiences by retired service personnel, and generational attitudes among police and Emergency Medical Services (EMS) towards mental health conditions.
 
Received: 2023-01-14Revised: 2023-01-25
Toxic Monuments and Mnemonic Regime Change
Authors: Rigney Ann
Published: February 2023

This article takes as its point of departure the recent wave of contestations relating to colonial-era monuments in Europe. While the toppling of monuments has long been a part of political regime change, recent attacks on monuments need to be understood instead, not as celebrations of a change that has already occurred, but as attempts to affect ‘mnemonic regime change’ as part of a larger struggle for racial equality and social justice. Monuments are materialisations of larger narratives that operate within a broader culture of memory; at the same time, they have a particular role to play in mnemonic contestations since they offer a physical platform for public performances of adherence to, or dissent from, dominant understandings of collective identity and memory. Using insights from the field of cultural memory studies, this article illustrates these dynamics with detailed reference to the controversy around the Edward Colston statue in Bristol. It argues that its dramatic toppling in June 2020 was part of a much longer and slower two-track process whereby the narrative underpinning Colston was undermined and an alternative narrative of Bristol’s complicity in the slave trade was unforgotten. It concludes by reflecting on the importance but also the limits of memory activism focussed on statues.
Analisis Tingkat Pengungkapan Transaksi Pihak Berelasi dan Pengaruhnya terhadap Nilai Perusahaan (Studi pada Industri Manufaktur)
Authors: Naibaho Revmianson
Published: February 2023

AbstrakTujuan – Penelitian ini bertujuan untuk mendeskripsikan tingkat pengungkapan transaksi pihak berelasi pada industri manufaktur dan membandingkan antar-sektornya serta menguji dan menganalisis pengaruhnya terhadap nilai perusahaan pada industri manufaktur yang terdaftar di Bursa Efek Indonesia.Metode Penelitian – Peneliti melakukan penelitian pada industri manufaktur yang terdaftar di Bursa Efek Indonesia dengan menggunakan teknik analisis konten dan melakukan uji analisis regresi linear berganda. Teknik analisis konten digunakan untuk mengetahui tingkat pengungkapan transaksi pihak berelasi dan uji analisis regresi linear berganda digunakan untuk mengetahui pengaruh di antara tingkat pengungkapan transaksi pihak berelasi dengan nilai perusahaan.Temuan – Hasil penelitian menunjukkan bahwa rata-rata tingkat pengungkapan transaksi pihak berelasi yang bersifat wajib pada industri manufaktur sebesar 77,87%, yang bersifat sukarela sebesar 58,28%, dan bersifat keseluruhan (oscore) sebesar 68,46%. Berdasarkan kepatuhan tingkat pengungkapan menurut Samaha dan Stapleton (2008), tingkat pengungkapan transaksi pihak berelasi yang bersifat wajib dan keseluruhan termasuk ke dalam kategori tingkat kepatuhan sedang dan tingkat pengungkapan transaksi pihak berelasi yang bersifat sukarela termasuk ke dalam kategori tingkat kepatuhan rendah. Peneliti juga menemukan hubungan positif di antara keempat model yang digunakan untuk menguji tingkat pengungkapan transaksi pihak berelasi dengan nilai perusahaan.Originalitas – Penelitian ini menganalisis tingkat pengungkapan transaksi pihak berelasi dengan menggunakan analisis konten dan menguji pengaruhnya terhadap nilai perusahaan karena belum terdapat penelitian yang menggunakan analisis konten tingkat pengungkapan transaksi pihak berelasi dan menguji pengaruhnya terhadap nilai perusahaan.
ANALISIS TINGKAT KESESUAIAN LAPORAN TAHUNAN DAN LAPORAN KEBERLANJUTAN DENGAN KERANGKA PELAPORAN TERINTEGRASI INTERNASIONAL
Authors: Sutiono Fidya
Published: February 2023

AbstrakTujuan – Penelitian ini menganalisis tingkat kesesuaian laporan tahunan dan laporan keberlanjutan pada perusahaan terbuka di Indonesia dengan kerangka pelaporan terintegrasi internasional yang diterbitkan oleh Integrated International Reporting Council (IIRC).Metode penelitian – Analisis konten digunakan pada sampel berjumlah 46 perusahaan yang terdaftar di Bursa Efek Indonesia. Tingkat kesesuaian laporan tahunan dal laporan terintegrasi dengan kerangka pelaporan terintegrasi dianalisis secara deskriptif dengan menggunakan instrumen penelitian delapan konten elemen pada kerangka pelaporan terintegrasi internasional.Temuan – Hasil penelitian menunjukkan bahwa perusahaan-perusahaan terbuka di Indonesia memiliki tingkat kesesuaian laporan tahunan dan laporan keberlanjutan sesuai dengan yang dipersyaratkan IIRC. Namun, masih diperlukan sedikit penyelarasan pada penerapan beberapa elemen konten pelaporan terintegrasi. Pengungkapan yang dilakukan perusahaan tergolong cukup sesuai dengan kerangka pelaporan terintegrasi internasional yang diterbitkan IIRC.Originalitas – Salah satu fokus utama dalam penelitian ini adalah tingkat kesesuaian laporan tahunan dan laporan keberlanjutan dengan kerangka pelaporan terintegrasi internasional. Penelitian yang mengukur tingkat kesesuaian kerangka pelaporan terintegrasi dengan menggunakan kedua laporan tersebut masih sangat terbatas terutama di Indonesia.