bluuebunny/crossref_metadata_2025 huggingface dataset:
Choriocapillaris Flow Signal Impairment in Sorsby Fundus Dystrophy
Authors: Hess Kristina , Raming Kristin , Gliem Martin , Charbel Issa Peter , Herrmann Philipp , Holz Frank G. , Pfau Maximilian
Published: February 2022

Purpose: The aim of the study was to quantify choriocapillaris (CC) flow alterations in early Sorsby fundus dystrophy (SFD) and to investigate the relationship of the CC flow deficits with the choroidal and outer retinal microstructure. Methods: In this prospective case-control study, 18 eyes of 11 patients with early SFD and 31 eyes of 31 controls without ocular pathology underwent multimodal imaging, including spectral-domain optical coherence tomography (OCT), followed by deep-learning-based layer segmentation. OCT angiography (OCTA) was performed to quantify CC flow signal deficits (FDs). Differences in CC FD density between SFD patients and controls were determined, and the relationships with choroidal thickness, retinal pigment epithelium-drusen complex (RPEDC) thickness and outer retinal layer thicknesses were analyzed using mixed-model analysis. Results: SFD patients exhibited a significantly greater CC FD density than controls (estimate [95% CI]: +20.0%FD [13.3; 26.7], p < 0.001 for SFD patients), even when adjusted for age. Square-root transformed choroidal thickness was a structural OCT surrogate of the CC FD density (−2.1%FD per √µm, p < 0.001), whereas RPEDC thickness was not informative regarding CC FD (p = 0.061). The CC FD density was associated with an altered microstructure of the overlying photoreceptors (outer segments, inner segments, and outer nuclear layer thinning of −0.19 μm, −0.08 μm and −0.30 μm per %FD, respectively, all p < 0.001). Conclusions: Patients with early SFD exhibit pronounced abnormalities of CC flow signal on OCTA, which are not limited to areas of sub-RPE deposits seen on OCT imaging. Thus, analysis of the CC flow may enable clinical trials at earlier disease stages in SFD.
Robot-Assisted Partial Cystectomy versus Open Partial Cystectomy for Patients with Urachal Cancer
Authors: Stokkel Laura E. , van de Kamp Maaike W. , Schaake Eva E. , Boellaard Thierry Nicolas , Hendricksen Kees , van Rhijn Bas W.G. , Mertens Laura S.
Published: February 2022

Introduction: Localized urachal cancer (UrC) can be treated with an open partial cystectomy (OPC) with en bloc resection of the urachal remnant and umbilicus. Robot-assisted partial cystectomy (RAPC) is an alternative approach, of which its safety and efficacy for UrC remains to be determined. In the present study, we analyze these outcomes after RAPC, compared with OPC. Methods: We retrospectively evaluated 55 cN0M0 UrC patients who underwent RAPC (n = 8) or OPC (n = 47) between 1994 and 2020. Overall survival (OS) and recurrence-free survival (RFS) were assessed using Kaplan-Meier methods. Positive surgical margins (PSM), port-site recurrences (PSR) versus wound recurrences were compared. Complications were recorded using the Clavien-Dindo classification. Results: Median follow-up was 40 months (IQR 21–95). Two-year OS and RFS for RAPC were 73% (95% confidence intervals (CI); 56–89 months) and 60% (95% CI; 42–78 months), respectively, versus 90% (95% CI; 85–95 months) and 66% (95% CI; 59–73 months) for OPC. PSM rate was 13% in both groups. PSR occurred in 2/8 (25%) patients after RAPC. No wound recurrences occurred after OPC. Postoperative complications occurred in 2/8 (25%) patients after RAPC, versus 5/47 (11%) after OPC (p = 0.27). Conclusion: Both RAPC and OPC seem feasible surgical modalities to treat localized UrC with comparable survival. The PSR rate of 25% after RAPC should prompt us to be cautious to recommend RAPC as no such recurrences were seen using OPC.
Challenges and Management of Long COVID in Individuals with Hematological Illnesses
Authors: Yelin Dana , Margalit Ili
Published: February 2022

COVID-19 has impacted hundreds of millions of people globally, a relatively large proportion of whom continue to suffer from ongoing, sometime debilitating symptoms. This phenomenon, termed “long COVID,” is difficult to diagnose and manage because of a paucity of objective findings and despite the abundance of descriptive data published so far. In this review, we aimed to describe the common manifestations of long COVID, diagnostic and management challenges, and address specific aspects in hematologic patients.
Efficacy and Safety of Super-Selective Bronchial Arterial Infusion Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer
Authors: Men Tonglin , Cui Qiaoyan , Liu Yongyu , Zhang Shenzhong
Published: February 2022

Objective: The objective was to study the effectiveness and safety of super-selective bronchial arterial infusion (SBAI) chemotherapy in the treatment of advanced stage non-small cell lung cancer (NSCLC). Methods: The clinical data of 120 advanced NSCLC patients were retrospectively analyzed. Among them, 60 NSCLC patients were treated with SBAI method, another 60 NSCLC patients received systemic intravenous chemotherapy as the control group. The efficacy and safety between two groups of patients were compared. Results: The objective response rate and disease control rate of NSCLC patients treated with SBAI were significantly higher than those of the control group (p < 0.05). The 3-month progression-free survival (PFS) rate (96.67%) and 6-month PFS rate (86.67%) of the SBAI group were significantly higher than those of the control group (73.33% and 56.67%) (p < 0.01). After treatment, the FACT-L scores of patients in the SBAI group were significantly higher than those of the control group (p < 0.05). The scores of all the 13 core symptom items and six symptom interference items of NSCLC patients in the SBAI group were lower than those of the control group (p < 0.05). The adverse reactions rate in the SBAI group were significantly lower than those in the control group (p < 0.05). Conclusion: The short-term efficacy of SBAI chemotherapy for advanced NSCLC is significantly higher than that of traditional peripheral intravenous chemotherapy, and it can significantly improve patients’ quality of life and reduce the incidence of adverse reactions.
Left Ventricular Wall Reconstruction with Autologous Vascularized Tunica Muscularis of Stomach in a Porcine Pilot Model
Authors: Schilling Tobias , Meyer Tanja , Brandes Gudrun , Hartung Dagmar , Tudorache Igor , Nolte Ingo , Wacker Frank , Hilfiker Andres , Höffler Klaus , Haverich Axel , Cebotari Serghei
Published: February 2022

Introduction: Surgical replacement of dysfunctional cardiac muscle with regenerative tissue is an important option to combat heart failure. But, current available myocardial prostheses like a Dacron or a pericardium patch neither have a regenerative capacity nor do they actively contribute to the heart’s pump function. This study aimed to show the feasibility of utilizing a vascularized stomach patch for transmural left ventricular wall reconstruction. Methods: A left ventricular transmural myocardial defect was reconstructed by performing transdiaphragmatic autologous transplantation of a vascularized stomach segment in six Lewe minipigs. Three further animals received a conventional Dacron patch as a control treatment. The first 3 animals were followed up for 3 months until planned euthanasia, whereas the observation period for the remaining 3 animals was scheduled 6 months following surgery. Functional assessment of the grafts was carried out via cardiac magnetic resonance tomography and angiography. Physiological remodeling was evaluated histologically and immunohistochemically after heart explantation. Results: Five out of six test animals and all control animals survived the complex surgery and completed the follow-up without clinical complications. One animal died intraoperatively due to excessive bleeding. No animal experienced rupture of the stomach graft. Functional integration of the heterotopically transplanted stomach into the surrounding myocardium was observed. Angiography showed development of connections between the gastric graft vasculature and the coronary system of the host cardiac tissue. Conclusions: The clinical results and the observed physiological integration of gastric grafts into the cardiac structure demonstrate the feasibility of vascularized stomach tissue as myocardial prosthesis. The physiological remodeling indicates a regenerative potential of the graft. Above all, the connection of the gastric vessels with the coronary system constitutes a rationale for the use of vascularized and, therefore, viable stomach tissue for versatile tissue engineering applications.
Chronic Cutaneous Disorders Are Associated with a More Favorable Disease Presentation and Outcome in Patients with Hodgkin Lymphoma
Authors: Marin Katja , Auvinen Päivi , Kuitunen Hanne , Kuittinen Outi
Published: February 2022

Introduction: In epidemiological studies, chronic inflammation or previous major infection have revealed to be associated with an increased risk of developing Hodgkin lymphoma (HL). The association of chronic inflammation with the disease outcome is poorly defined. In this retrospective study based on 92 consecutive HL patients, we explored the incidence of previous inflammatory processes or previous major infection in newly diagnosed HL patients and their association with treatment outcome. Methods: Medical history before lymphoma diagnosis including previous infection; dental inflammation; cutaneous problems; and inflammatory respiratory, gastrointestinal, or musculoskeletal diseases was collected from the patient records. Also clinical HL presentation, given treatments, and the disease outcome were recorded. Results: Forty-six percent of HL patients had some of the studied inflammatory factor at the time of diagnosis. Chronic dermatological diseases were present in 16.3% of patients, and they were associated with an improved relapse-free survival (p = 0.028). Dermatological issues were also associated with early-stage disease and the absence of B-symptoms. Other studied inflammatory factors were not associated with any clinical variables or treatment outcome. Conclusion: Our results demonstrated that among patients with HL, preexisting cutaneous symptoms are associated with a limited-stage disease, the absence of B-symptoms, and favorable prognosis.
Vitamin E Decreases Cytotoxicity and Mitigates Inflammatory and Oxidative Stress Responses in a Ferret Organotypic Brain Slice Model of Neonatal Hypoxia-Ischemia
Authors: Kolnik Sarah , Corry Kylie , Hildahl Kate , Filteau Jeremy , White Olivia , Brandon Olivia , Farid Lily , Shearlock AnnaMarie , Moralejo Daniel , Juul Sandra E. , Nance Elizabeth A. , Wood Thomas R.
Published: February 2022

The gyrencephalic ferret brain is an excellent model in which to study hypoxia-ischemia (HI), a significant contributor to neurological injury in neonates. Vitamin E, an essential fat-soluble antioxidant, reduces oxidative stress and inflammation in both animal models and human infants. The aim of this study was to assess the effects of vitamin E after oxygen-glucose deprivation (OGD) in an organotypic ferret brain slice model of neonatal HI. We hypothesized that vitamin E would decrease cytotoxicity, inflammation, and oxidative stress in OGD-exposed brain slices. Term-equivalent ferrets were sacrificed at postnatal (P) day 21–23 and 300 µM whole-hemisphere brain slices were obtained. During a 24-h rest period, slices were cultured in either nontreated control conditions or with erastin, a promotor of oxidative stress. Slices were then exposed to 2 h of OGD followed by vitamin E (25–100 IU/kg), erastin (10 µM), or ferrostatin (1 µM), an inhibitor of ferroptosis. Relative cytotoxicity was determined using a lactate dehydrogenase assay, cell death was quantified via nuclear propidium iodide staining, oxidative stress was quantified via cellular glutathione (GSH) levels, and target genes responsive to oxidative stress and inflammation were evaluated by qRT-PCR. OGD increased cytotoxicity, which was significantly reduced by treatment with vitamin E. Vitamin E also preserved GSH after OGD and decreased amplification of certain markers of oxidative stress (CHAC1, SLC7A11) and inflammation (TNF-alpha, IL-8). Vitamin E remained protective after pretreatment with erastin and was more protective than ferrostatin, presumably due to its added anti-inflammatory properties. Results from the ferret whole-hemisphere OGD model support the premise that vitamin E neuroprotection is mediated by restoring GSH and acutely decreasing inflammation and oxidative stress after neonatal HI.
Do desmonte da favela à criação do parque proletário: política assistencial?
Authors: Pinheiro Lima Jaqueline de Cássia
Published: February 2022

Do desmonte da favela à criação do parque proletário: política assistencial?
Caminhada de iniciação de Márico Caires na África do Oeste
Authors: Caires Márcio
Published: February 2022

Dezembro de 2006, fim do primeiro ano em que o Programa Ação Griô é lançado no Brasil, idealizado e coordenado por Líllian Pacheco e Márcio Caires do Ponto de Cultura Grãos de Luz e Griô, Lençóis, Bahia, em parceria com Célio Turino, secretário da Secretaria de Programas e Projetos Culturais do Ministério da Cultura do Brasil. Neste momento histórico em que Márcio foi iniciado como o Velho Griô pelas tradições orais do Brasil, ele vai para o Mali, África do Oeste, em busca de uma profunda vivência no berço do nascimento da tradição Griô na África e de uma compreensão do termo Griô abrasileirado no processo de criação da Pedagogia Griô desde 1998. Nesta caminhada, ele escreve cartas para sua família contando suas vivências e aprendizagens com o seu Griô mestre africano, Djeli Mory Diabaté, o aprendiz Griô Djbril Diabaté, seu guia africano Yaya Konatê e com outros Griôs no Mali.
Dos griots aos Griôs: a importância da oralidade para as tradições de matrizes africanas e indígenas no Brasil
Authors: De Lima Mestre Alcides , Da Costa Ana Carolina Francischette
Published: February 2022

Este artigo tem o intuito de discutir a temática da tradição oral, sua função e importância em grupos que transmitem sua história e memória social através da oralidade. Neste caso, trataremos especificamente da figura do griot africano e, a partir de então, buscaremos delinear a identidade dos Griôs brasileiros e de que maneira se dá essa apropriação, situando-a em um contexto de recriação e reelaboração de práticas africanas no Brasil diante da colonização e diáspora. Nesse processo, a palavra Griô é uma apropriação do termo existente em sociedades africanas e sua justificativa, no Brasil, é norteada também pelas contribuições culturais de raízes indígenas.
Fundamentos da produção partilhada do conhecimento e o saber do Mestre Griô.
Authors: Lazaneo Caio , Battistella Roberta Navas , Bairon Sérgio
Published: February 2022

Fundamentos da produção partilhada do conhecimento e o saber do Mestre Griô.
Pedagogia Griô em atos do currículo nas escolas quilombolas de Rio de Contas - Bahia
Authors: Pacheco Patrícia
Published: February 2022

Pedagogia Griô em atos do currículo nas escolas quilombolas de Rio de Contas - Bahia
Derechos humanos, diversidad y interdisciplinaridad
Authors: Rojas Rodrigo Montoya
Published: February 2022

Derechos humanos, diversidad y interdisciplinaridad.
No sesquicentenário de nascimento de Franz Boas
Authors: Moura Margarida Maria
Published: February 2022

No sesquicentenário de nascimento de Franz Boas
Direitos Humanos: caminhos entre a Antiguidade Clássica e o Mundo Contemporâneo. Resenha do livro "A afirmação histórica dos direitos Humanos", de Fábio Konder Comparato
Authors: Seixas Luiz Carlos
Published: February 2022

Resenha do livro "A afirmação histórica dos direitos Humanos", de Fábio Konder Comparato
Memorial do convento: o romance histórico encontra a tragédia grega
Authors: Larêdo Filipe Nassar
Published: February 2022

O presente artigo nasce da hipótese de que o romance histórico Memorial do convento, de José Saramago, publicado em 1982, traz em sua composição traços característicos da tragédia grega que contribuem para a formação de caminhos para uma nova leitura do romance histórico, de modo que possam expandir a percepção do leitor sobre o gênero, por meio de reflexões despertadas pelos referenciais literários que a obra nos sugere. Sob tal perspectiva, e com o objetivo de aproximar os conceitos de tragédia grega ao romance histórico construído por Saramago, traremos os conceitos do historiador austríaco Albin Lesky que, em sua obra A tragédia grega, enxerga o trágico como um princípio filosófico revelador de uma visão específica do mundo. Como suporte para a reflexão aqui proposta, utilizaremos também os argumentos do historiador francês Jean-Pierre Vernant, os quais, cruzados com a perspectiva de Alcmeno Bastos sobre o romance histórico e com a de Benedito Nunes sobre o romantismo, encontrar-se-ão com os do inglês Terry Eagleton. Teresa Cristina Cerdeira da Silva, por sua vez, uma das maiores pesquisadoras da obra de Saramago, no Brasil, é outra referência em nossas reflexões, visto que, em alguns de seus estudos, ocorrem sugestões instigantes para uma aproximação entre o romance em questão e certos aspectos da tragédia.
Limiares entre ficção e história: elementos da personagem romanesca em Memórias de Branca Dias, de Miguel Real
Authors: Souza Aldinida de Medeiros , Araújo Andréia Rafael de
Published: February 2022

A metaficção historiográfica permite que a autoria dê “asas” aos mitos, elaborando personagens com maior ou menor reflexão crítica nas narrativas. O presente ensaio é um estudo que parte das relações entre Literatura e História no romance Memórias de Branca Dias (2009), de Miguel Real, publicado pela primeira vez em 2003, a fim de analisar a protagonista deste romance. A figura da Branca Dias real tornou-se um mito, lendas surgiram em torno deste nome; é uma personagem in presentia, em algumas ficções, in absentia em outras. Buscamos identificar, com base n’A construção da Personagem Romanesca (2008), de Cristina Vieira, elementos que mostram um discurso crítico-reflexivo por parte da autoria de Miguel Real, o qual nos permite rememorar Branca Dias como uma mulher de luta, pois o romance, além de possibilitar que se retorne ao Brasil colonial, mostra a mão férrea da Igreja Católica no período da Inquisição, contra a qual Branca lutou a vida inteira.
letras pacientes em Pessoa(s) por homem completo
Authors: Ribeiro Fernando Jorge Oliveira
Published: February 2022

Neste artigo reflecte-se com base em F.Pessoa, - sobre a condição de criador literário em época da modernidade; em suas quatro partes : 1-Pessoa, por «nova linguagem»;2-Ou um caso clínico, Pessoa?;3- O «Freudismo» ?- pergunta Pessoa; 4- Do “Homem Completo”; demonstra-se em que medida a ciência da análise da psique não supera a sínteses da psique, a qual vigora pela criação literária que responde cabalmente oferecendo ao homem moderno adpataçãoa artificial, para fazer face a época de bárbaros e torná-lo peça integral de Humanidade.
João Pedro Porto a fundo, na raiz do humano
Authors: Antunes Susana L. M.
Published: February 2022

Entrevista com o escritor açoriano João Pedro Porto que este ano assinala uma década em que publicou o seu primeiro livro. Para além de escritor, João Pedro Porto exerce a profissão de psicoterapeuta.
La Comunicación Organizacional vista desde México
Authors: Camiade Cristina Barroso , Castrejón Eva María Pérez
Published: February 2022

En este artículo se presenta el desarrollo de la disciplina en el tiempo para conocer los aportes teóricos más importantes que se han venido desarrollando en México, y así por medio del caso de la Universidad Popular Autónoma del Estado de Puebla (Upaep) exponer las principales áreas de oportunidad que tiene la disciplina dentro de la vida académica y profesional de los egresados como una forma de entrelazar el desarrollo teórico con la práctica universitaria.
Propuesta metodológica para la investigación de la comunicación en las organizaciones
Authors: Verdugo Manuela Matus , Munguía Jorge Alfredo Estupiñán , Zermeño-Espinosa Ma Elena
Published: February 2022

El propósito del trabajo es presentar una propuesta metodológica para investigar la comunicación en las organizaciones, considerando la dimensión praxeológica del ámbito educativo, así como la profesional. Se identifican tres actores clave: el practicante profesional, es decir, el estudiante que se acerca al mundo profesional como parte de su formación académica; el profesional en Comunicación, quien soluciona necesidades de comunicación en organizaciones del sector público, social y privado; y las organizaciones representando, para el primero, la unidad receptora y, para el segundo, el mercado laboral.
Teoría de la Comunicación Estratégica Enactiva
Authors: Masson Sandra
Published: February 2022

Este trabajo expone algunos elementos diferenciales de la metaperspectiva de la Comunicación Estratégica Enactiva (CEE) en las organizaciones. Presenta una historización de la teoría de la CEE y su correlato metodológico, la Investigación Enactiva en Comunicación (IEC), focalizada en los ejes investigación y enseñanza. Describe sus contribuciones en la redefinición de las competencias del comunicador organizacional, puntualizando diferencias teóricas sobre el aplicar y el operar comunicación a partir de las siete operaciones cognitivas de una IEC.
Organización, cultura y comunicación
Authors: González Rafael Ávila , García José Alfredo Andrade
Published: February 2022

Este trabajo anticipa otro en desarrollo, de ahí que sus límites sean evidentes. En él se inquiere por las posibilidades teóricas de postular relaciones supradisciplinares a partir de los saberes que se constituyeron en la teoría de la organización, los estudios de cultura organizacional y el campo de la comunicación en organizaciones formales. Atiende, en primera instancia, la necesidad de recuperar las raíces de la organización del conocimiento, de modo que las nociones de disciplina y sucedáneas hagan sentido en un marco histórico social y no exclusivamente epistémico. En seguida, se concentra en la caracterización general de la supradisciplina como respuesta a la creciente complejidad del capitalismo avanzado, sus aporías y momentos críticos. Finaliza con la presentación de algunas premisas mínimas para el estudio conjunto de la comunicación, la cultura y el sistema organizacional, reconociendo que es en ese dominio, el de la organización formal, donde se generan los imperativos tecnodiscursivos que operan a manera de cierre sobre los intereses epistémicos de aquellas dos áreas.
Longe da mera ficção
Authors: Menger Jonathan Bernardo
Published: February 2022

O texto objetiva fazer uma análise crítico-comparativa entre duas obras estrangeiras que discorrem sobre os terrores do nazismo na 2ª Guerra, trazendo possíveis reflexões para os dias atuais. 

 

BOYNE, John. O menino do pijama listrado. São Paulo: Seguinte, 2016.

DOWSWELL, Paul. O órfão de Hitler. São Paulo: Planeta, 2016.
A escola francesa de som direto: Jean-Pierre Ruh e Éric Rohmer
Authors: Puccini Sérgio
Published: February 2022

O artigo trata de um dos mais destacados representantes da escola francesa de som direto, o técnico Jean-Pierre Ruh, a partir de seu trabalho com o cineasta Éric Rohmer nos filmes Ma nuit chez Maud (Minha noite com ela, 1969), Le genou de Claire (O joelho de Claire, 1970) e L'amour l'après-midi (Um amor à tarde, 1972). Tendo como principal base os depoimentos do próprio Jean-Pierre Ruh, pretendemos focar em questões caras à escola do som direto, principalmente no que tange aos sons fora de campo, às imperfeições de som, e aos sons ordinários, entendidas dentro de uma concepção que valoriza uma verdade e uma singularidade do som no filme. Observou-se que cada filme possui uma particularidade própria, assim como um som único, e todos exploram as vozes sempre projetadas no espaço, fechado ou aberto, o que acrescenta uma informação de perspectiva e profundidade.
Apontamentos sobre o Cinema Científico: Arlindo Machado
Authors: Almeida Jane de
Published: February 2022

Arlindo Machado realizou filmes e escreveu artigos sobre um tipo de cinema pouco debatido pelo campo comunicacional chamado “cinema científico”. Esse artigo discute suas ideias sobre o tema, articulando conceitos e a historiografia sobre as origens do cinema por meio de seus escritos sobre os pré-cinemas e os pós-cinemas. O diálogo com suas obras sugere questões a respeito da invisibilidade do cinema científico, das máquinas pré-cinemáticas e suas relações com a ciência, além de casos brasileiros de filmes científicos. A partir dos elementos abordados, especula-se a possibilidade de composição de uma linguagem que ultrapasse o mero registro de imagens. Ao final, discute-se sobre a estética e a ética do realismo atraente de imagens médicas e seus aspectos repulsivos, assim como sobre o simulacro integral das imagens astronômicas dos nossos dias.
Nangui tereka, hablando duro en la vida política de las mujeres Waorani
Authors: Bravo Díaz Andrea
Published: February 2022

Este artículo explora la participación de las mujeres Waorani de la Amazonía ecuatoriana, en lo que ellas reconocen como la vida política. Esta noción, en comunidades ubicadas cerca de carreteras petroleras, hace referencia a los encuentros y negociaciones con Otros. La vida política local, en estas comunidades, es una expresión de resistencia Waorani distinta, aunque complementaria, a las grandes demostraciones anti-extractivas que han llamado la atención de la opinión pública e investigadores. El artículo ofrece un aporte a los estudios amazónicos sobre liderazgo al explorar un discurso denominado nangui tereka (hablar duro), un arte perfeccionado por varias mujeres Waorani. Hablar duro es una forma de expresar la fuerza o valentía (piñe, pienguimamo), que se cultiva a lo largo de la vida a través de una serie de prácticas corporales intergeneracionales.
Aspectos bucais da síndrome de Rubinstein-Taybi: relato de dois casos clínicos
Authors: Barros Fabiana Mesquita , Iida Letycia , Alves Thais Dutra , Castorino Aparecida Angélica , Martins Fabiana , Gallotini Marina
Published: February 2022

A síndrome de Rubinstein-Taybi é uma doença multissistêmica genética rara caracterizada por dimorfismo facial típico, retardo de crescimento, deficiência mental e múltiplas anormalidades dentárias. Este relato de caso descreve os achados orofaciais da síndrome de Rubinstein-Taybi que afetou um menino brasileiro de onze anos de idade e uma menina de dez anos. As descobertas orais dos pacientes, tais como lábios superiores finos, retenção prolongada dos dentes decíduos e hipodontia são relatados, e o manejo clínico é discutido.
Prevalence of idiopathic osteosclerosis in the mandible: a cone beam computed tomography study
Authors: Mehdizadeh Mojdeh , Firoozi Farnoush , Soltani Parisa
Published: February 2022

Objective: The aim of this study is to determine the prevalence of idiopathic osteosclerosis (IO) in the mandible in an Iranian subpopulation using cone beam computed tomography (CBCT). Methods: This cross-sectional study was performed on all CBCT images obtained in 2010-2014 from the archive of Oral and Maxillofacial Radiology Department at Isfahan Dental School. Images were evaluated by two observers in identical room and monitoring conditions. IO was defined as homogenous radiopacities with no particular etiology, ranging from 2 mm to 2 cm in size. Demographic information of all patients, as well as the lesion’s number, location, border, shape, and association with adjacent teeth were recorded. Results: From 377 CBCT images, 43 images (11.4%) had at least one IO lesion. Two separate IO lesions were detected in six patients; therefore, 49 IO lesions were found in total. No gender differences were observed in IO prevalence (P = 0.806). Although most common in patients who were in their 30s, IO prevalence was not statistically different among age groups (P = 0.369). IO was most frequent in the molar region, with 63.2% of lesions. Conclusion: IO prevalence was 11.4% in the studied population and was not statistically different between age groups or sexes. Most lesions were found in the mandibular molar region.
Bandersnatch: uma crítica de processo
Authors: Estorillio Rodrigo dos Santos
Published: February 2022

A complexa sistematização das narrativas interativas se processa nas inovações homem-máquina, potencializadas pelo uso de ferramentas tecnológicas que manipulam interfaces de aplicativos hipermidiáticos, modelando scripts em linguagem HTML que se traduzem em conceitos narratológicos e conteúdo multitrama aos usuários em plataformas e redes de comunicação. O recorte desta pesquisa parte do processo de criação hipertextual em multitrama, Bandersnatch, e seu tratamento em roteiro de longa-metragem de ficção interativa. A sistematização narratológica gravita um processo de readequação estrutural por conta das potencialidades interativas que o meio digital on-line propicia ao interator na fruição do filme-jogo. O fenômeno ocorre conforme um menor ou maior grau de abertura da obra ou compartilhamento indicial de autoria, em que a dimensão multilinear da história provoca cognitivamente o sistema nervoso por meio do “envolvimento extensivo do corpo na sua globalidade psicossensorial, sinestésica”[1] (SANTAELLA, 2010). Objetivo demonstrar como a manipulação dos elementos estruturais dos mundos ficcionais da narrativa interativa revela a multidimensionalidade do real frente às relações entre o virtual e o atual, operando complexidades intersemióticas por meio dos fenômenos de linguagem e signagens.
[1] SANTAELLA, L. Culturas e artes do pós-humano: da cultura das mídias à cibercultura. 4ª ed.. São Paulo: Editora Paulus, 2010, p. 227.
 
[1] SANTAELLA, Lúcia. Culturas e artes do pós-humano: da cultura das mídias à cibercultura. 4ª ed.. São Paulo: Editora Paulus, 2010, p. 227.
Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk
Authors: Coassin Stefan , Chemello Kevin , Khantalin Ilya , Forer Lukas , Döttelmayer Patricia , Schönherr Sebastian , Grüneis Rebecca , Chong-Hong-Fong Clément , Nativel Brice , Ramin-Mangata Stéphane , Gallo Antonio , Roche Mathias , Mühlegger Beatrix , Gieger Christian , Peters Annette , Zschocke Johannes , Marimoutou Catherine , Meilhac Olivier , Lamina Claudia , Kronenberg Florian , Blanchard Valentin , Lambert Gilles
Published: February 2022

Background:

Lp(a) (lipoprotein [a]) is a highly atherogenic lipoprotein strongly associated with coronary artery disease (CAD). Lp(a) concentrations are chiefly determined genetically. Investigation of large pedigrees with extreme Lp(a) using modern whole-genome approaches may unravel the genetic determinants underpinning this pathological phenotype.

Methods:

A large family characterized by high Lp(a) and increased CAD incidence was recruited by cascade screening. Plasma lipids, lipoproteins, and apolipoproteins concentrations, as well as the size of apo(a) isoforms, were determined enzymatically by high-resolution mass spectrometry and Western blot, respectively. Whole-exome sequencing was performed to search for rare defects in modifier genes. Genetic risk scores (GRS) for Lp(a) and CAD were calculated and their discriminative power was assessed.

Results:

Seventeen individuals displayed extreme Lp(a) levels including 6 with CAD. Whole-exome sequencing showed no hint for genetic defects outside the
LPA
locus. The extreme Lp(a) phenotype segregated with the presence of a short apo(a) isoform containing 21 Kringle IV domains. This allele was characterized by the presence of three rare strongly Lp(a) increasing single nucleotide polymorphisms and a significantly increased load of oxidized phospholipids per Lp(a) particle. An Lp(a) GRS consisting of 48 single nucleotide polymorphisms that represent 2001 genome-wide significant
LPA
single nucleotide polymorphisms, efficiently captured the hyper-Lp(a) phenotype and discriminated affected and nonaffected individuals with great accuracy. The genome-wide GRS for CAD, encompassing 6.6 million single nucleotide polymorphisms, was very high for most family members (>97.5 percentile of the reference population), but this observation was no longer valid when the contribution of the
LPA
locus was omitted.

Conclusions:

High-Lp(a) phenotypes can be successfully captured using the Lp(a) GRS even among closely related family members. In hyper-Lp(a) individuals,
LPA
can be a major locus driving a very high CAD GRS. This underpins the large contribution of the
LPA
locus to the cardiovascular genetic risk in families.
Five-Year Outcomes After Fractional Flow Reserve–Based Deferral of Revascularization in Chronic Coronary Syndrome: Final Results From the J-CONFIRM Registry
Authors: Kuramitsu Shoichi , Matsuo Hitoshi , Shinozaki Tomohiro , Horie Kazunori , Takashima Hiroaki , Terai Hidenobu , Kikuta Yuetsu , Ishihara Takayuki , Saigusa Tatsuya , Sakamoto Tomohiro , Suematsu Nobuhiro , Shiono Yasutsugu , Asano Taku , Tsujita Kenichi , Masamura Katsuhiko , Doijiri Tatsuki , Toyota Fumitoshi , Ogita Manabu , Kurita Tairo , Matsuo Akiko , Harada Ken , Yaginuma Kenji , Sonoda Shinjo , Yokoi Hiroyoshi , Tanaka Nobuhiro ,   on behalf of the J-CONFIRM Investigators
Published: February 2022

Background:

Little large-scale data is available about the long-term (beyond 3 years) clinical outcomes after fractional flow reserve (FFR)–based deferral of revascularization in clinical practice. We sought to assess the 5-year outcomes after deferral of revascularization based on FFR.

Methods:

The J-CONFIRM registry (Long-Term Outcomes of Japanese Patients With Deferral of Coronary Intervention Based on Fractional Flow Reserve in Multicenter Registry) prospectively enrolled 1263 patients with 1447 lesions in whom revascularization was deferred based on FFR from 28 Japanese centers. The primary study end point was the cumulative 5-year incidence of target vessel failure (TVF), including cardiac death, target vessel–related myocardial infarction, and clinically driven target vessel revascularization.

Results:

Five-year follow-up was completed in 92.2% of patients. The 5-year TVF rate was 11.6% in deferred lesions, mainly driven by clinically driven target vessel revascularization (9.8%). Cardiac death and target vessel–related myocardial infarction were 1.9% and 0.95%, respectively. Cumulative 5-year incidence of TVF was similar between the FFR 0.75 to 0.80 and 0.81 to 0.85 groups even after adjustment for baseline characteristics (12.2% versus 13.0%, inverse probability–weighted hazard ratio, 0.86 [95% CI, 0.46–1.60];
P
=0.63). Compared with the almost normal FFR (0.86–1.00) group, the significant (<0.75) and borderline (0.75–0.85) FFR groups showed a higher incidence of TVF at 5 years (29.9% versus 12.8% versus 8.6%,
P
<0.001). Independent predictors of the 5-year TVF were hemodialysis, FFR value, left main coronary artery lesion, prior percutaneous coronary intervention, and male sex.

Conclusions:

The 5-year TVF rate was 11.6% in deferred lesions, mainly driven by clinically driven target vessel revascularization. Notably, cardiac death and target vessel–related myocardial infarction rarely occurred during the follow-up. Our findings highlight the long-term safety of FFR-based deferral of revascularization in patients with chronic coronary syndrome.

Registration:

URL:
https://www.umin.ac.jp/ctr
; Unique identifier: UMIN000014473.
Coronary Revascularization Versus Optimal Medical Therapy in Renal Transplant Candidates With Coronary Artery Disease: A Systematic Review and Meta‐Analysis
Authors: Siddiqui Muhammad U. , Junarta Joey , Marhefka Gregary D.
Published: February 2022

Background

Coronary artery disease (CAD) is highly prevalent in patients with chronic kidney disease and is a common cause of mortality in end‐stage renal disease. Thus, patients with end‐stage renal disease are routinely screened for CAD before renal transplantation. The usefulness of revascularization before transplantation remains unclear. We hypothesize that there is no difference in all‐cause and cardiovascular mortality in waitlisted renal transplant candidates with CAD who underwent revascularization versus those treated with optimal medical therapy before transplantation.

Methods and Results

This meta‐analysis was reported according to the
Preferred Reporting Items for Systematic Review and Meta‐Analyses
guidelines. MEDLINE, Scopus, and Cochrane Central Register of Controlled Trials were systematically searched to identify relevant studies. Risk of bias was assessed using the modified Newcastle‐Ottawa Scale and Cochrane risk of bias tool. The primary outcome of interest was all‐cause mortality. Eight studies comprising 945 patients were included (36% women, mean age 56 years). There was no difference in all‐cause mortality (risk ratio [RR], 1.16 [95% CI, 0.63–2.12), cardiovascular mortality (RR, 0.75 [95% CI, 0.29–1.89]), or major adverse cardiovascular events (RR, 0.78 [95% CI, 0.30–2.07]) when comparing renal transplant candidates with CAD who underwent revascularization versus those who were on optimal medical therapy before renal transplant.

Conclusions

This meta‐analysis demonstrates that revascularization is not superior to optimal medical therapy in reducing all‐cause mortality, cardiovascular mortality, or major adverse cardiovascular events in waitlisted kidney transplant candidates with CAD who eventually underwent kidney transplantation.
ABCD‐GENE Score and Clinical Outcomes Following Percutaneous Coronary Intervention: Insights from the TAILOR‐PCI Trial
Authors: Capodanno Davide , Angiolillo Dominick J. , Lennon Ryan J. , Goodman Shaun G. , Kim Sang‐Wook , O'Cochlain Fearghas , So Derek Y. , Sweeney John , Rihal Charanjit S. , Farkouh Michael , Pereira Naveen L.
Published: February 2022

Background

In TAILOR‐PCI, genotype‐guided selection of P2Y
12
inhibitors after percutaneous coronary intervention did not significantly reduce the risk of ischemic events at 12 months. The Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping (ABCD‐GENE) score identifies patients with high platelet reactivity on clopidogrel at increased risk of ischemic events. The aim of this study was to investigate the value of the ABCD‐GENE score for tailoring P2Y
12
inhibitor selection after percutaneous coronary intervention.

Methods and Results

In a post hoc analysis of the TAILOR‐PCI, outcomes were analyzed by ABCD‐GENE score and allocation to genotype‐guided or conventional P2Y
12
inhibitor selection. Primary (death, myocardial infarction, or stroke) and secondary (cardiovascular death, myocardial infarction, stroke, stent thrombosis, or severe recurrent ischemia) outcomes were assessed. Among 3883 patients discharged on clopidogrel in the genotype‐guided and conventional therapy groups, 15.8% and 84.2% had high (≥10 points) or low (<10) ABCD‐GENE scores, respectively. At 12 months, both the primary (5.2% versus 2.6%,
P
<0.001) and secondary outcomes (7.7% versus 4.6%,
P
=0.001) were significantly increased in patients with high ABCD‐GENE score. Among 4714 patients allocated to genotype‐guided or conventional therapy, the former did not significantly reduce the 12‐month risk of the primary and secondary outcomes in both the high and low ABCD‐GENE score groups (p
interaction
=0.48 and 0.27, respectively).

Conclusions

Among patients with percutaneous coronary intervention on clopidogrel, the ABCD‐GENE score was helpful in identifying those at higher risk. The ABCD‐GENE score may potentially enhance the precision of tailored selection of P2Y
12
inhibitors, which needs to be confirmed in prospective investigations.

Clinical Trial Registration

URL:
http://www.clinicaltrials.gov
. Unique Identifier: NCT01742117.
A new species of sublittoral marine copepod, Normanella parvisetosa sp. nov. (Harpacticoida, Normanellidae), from the Southern Sea of South Korea
Authors: Kim Jong Guk , Kim Sung Hoon , Yoon Seong Myeong
Published: February 2022

A new harpacticoid species, Normanella parvisetosa sp. nov., belonging to the family Normanellidae Lang, 1944, is described from subtidal habitats in the Southern Sea of South Korea. This new species is assigned to the minuta-lineage, based on the rostrum with a pointed apical tip, the five-segmented female antennule, the female P5 exopod without a distinct notch on the outer margin, and well-developed caudal setae IV and V each bearing an internal fracture plane. Normanella parvisetosa sp. nov. is morphologically close to N. incerta Lang, 1934, N. porosa Noodt, 1964, and N. obscura Lee & Huys, 1999, whereas the new species is distinguished from females of these species in the shape of the rostrum with a pointed tip, the relative length to width ratio of the caudal rami, the second endopodal segment of the second to fourth legs, the exopod of the fifth leg, and the relative length of setae on both rami of the fifth leg. Herein, we provide a detailed description and illustrations of Normanella parvisetosa sp. nov., which is the second Normanella species identified in Korean waters.
FDI Policy in India: With Special Reference to the Multi-Brand Retail FDI Policy
Authors: Chakraborty Paromita
Published: February 2022

This article attempts to trace the FDI policy in India from India’s Independence

till the economic liberalisation in 1991 and onwards. It highlights how different regimes approached the FDI policy in India, from ‘hostility’ to ‘accommodation’ to ‘collaboration’. The article then looks at the multi-brand retail FDI policy which was recently introduced in India. This policy was one of the hallmarks of the United Progressive Alliance (UPA II) regime and marked a significant push towards a more extensive economic reforms programme. It clearly stated that if this policy is operationalised, it will result in a big boost in investments in our country. However, most of the Indian states, the Left parties and various regional parties opposed the introduction of FDI in the multi-brand retail sector. They stated that this policy would harm the Indian economy in the long run. The article also focuses on two important stakeholders of this policy, namely the farming sector and the unorganised retailers. It looks at the advantages and the disadvantages of the multi-brand retail FDI policy on these two sectors along with their responses.
Deal-making, elite networks and public–private hybridisation: More-than-neoliberal urban governance
Authors: Gibson Chris , Legacy Crystal , Rogers Dallas
Published: February 2022

In this commentary, we argue that augmented concepts and research methods are needed to comprehend hybrid urban governance reconfigurations that benefit market actors but eschew competition in favour of deal-making between elite state and private actors. Fuelled by financialisation and in response to planning conflict are regulatory reforms that legitimise opaque alliances in service of infrastructure and urban development projects. From a specific city (Sydney, Australia) we draw upon one such reform – Unsolicited Proposals – to point to a broader landscape of hybrid urban governance, its reconfigurations of power and potential effect on cities. Whereas neoliberal governance promotes competition and views the state and private sectors as distinct, hybrid urban governance leverages state monopoly power and abjures market competition, instead endorsing high-level public–private coordination, technical and financial expertise and confidential deal-making over major urban projects. We scrutinise how Unsolicited Proposals normalise this approach. Commercial-in-confidence protection and absent tender processes authorise a narrow constellation of influential private and public actors to preconfigure outcomes without oversight. Such reforms, we argue, consolidate elite socio-spatial power, jeopardise city function and amplify corruption vulnerabilities. To theorise hybrid urban governance at the intersection of neoliberalism and Asia-Pacific state-capitalism, we offer the concepts of coercive monopoly (where market entry is closed, without opportunity to compete) and de jure collusion (where regulation reforms codify informal alliances among elites connected across government and corporate and consultancy worlds). We call for urban scholarship to pay closer attention to public–private hybridisation in governance, scrutinising regulatory mechanisms that consecrate deal-making and undermine the public interest.
Patient‐Defined Goals for Obstructive Sleep Apnea Treatment
Authors: Cai Yi , Tripuraneni Priyanka , Gulati Arushi , Stephens Erika M. , Nguyen Dang‐Khoa , Durr Megan L. , Chang Jolie L.
Published: February 2022

Objectives

To characterize the treatment goals and values of adult patients with obstructive sleep apnea (OSA).

Study Design

Mixed methods design based on semistructured interviews followed by cross‐sectional surveys.

Setting

Academic medical center and integrated managed care consortium.

Methods

Phase 1 involved qualitative analysis of focus groups and interviews to define treatment goal categories. Phase 2 included analysis of cross‐sectional surveys on most important treatment goals from patients with OSA presenting to sleep surgery clinic. Positive airway pressure (PAP) use, Epworth Sleepiness Scale score, and apnea‐hypopnea index were obtained to determine influences on goal choices.

Results

During focus groups and interviews, treatment goal themes identified included improving sleep quality, reducing daytime sleepiness, snoring sound reduction, and health risk reduction. In phase 2, 536 patients were surveyed, and they reported the primary treatment goals of health risk reduction (35%), sleep quality improvement (28%), daytime sleepiness improvement (21%), and snoring sound reduction (16%). The primary treatment goal was associated with age (P <. 0001), excessive daytime sleepiness (Epworth Sleepiness Scale score >10, P <. 0001), PAP use status (P <. 0001), and OSA severity (apnea‐hypopnea index, P <. 0001). Severity of OSA was associated with increasing proportion of patients choosing health risk reduction as the main treatment goal (P <. 05).

Conclusions

Adult OSA treatment goal choices vary with age, symptoms, PAP history, and OSA severity. Understanding patient‐specific goals is the essential first step in the shared decision‐making process when choosing surgical or nonsurgical treatments. Ultimately, goal‐focused discussions ensure alignment of priorities and definitions of success between the patient and the provider.
Cost‐effectiveness of Canal Wall‐Up vs Canal Wall‐Down Mastoidectomy: A Modeling Study
Authors: Bu Daniel D. , Schwam Zachary G. , Kaul Vivian F. , Wong Kevin , Fan Caleb , Wanna George B. , Cosetti Maura K. , Perez Enrique
Published: February 2022

Objective

To assess the relative lifetime costs, benefits, and cost‐effectiveness between the 2 approaches, canal wall‐up (CWU) and canal wall‐down (CWD) tympanomastoidectomy, used in the treatment of cholesteatomas.

Study Design

Markov state transition model.

Setting

Tertiary academic health system.

Methods

A Markov state transition model was used to simulate outcomes across the patient lifetime. Outcome and complication probabilities were obtained from the existing literature. Costs were calculated from the payer perspective, with procedure, hospital, clinic, and physician cost derived from Medicare reimbursement. Quality‐adjusted life years (QALYs) were used to represent effectiveness and utility. One‐way and probability sensitivity analyses (PSAs) were conducted.

Results

The base case analysis, assuming a 40‐year‐old patient, yielded a lifetime cost of $14,214 for a patient treated with the CWU approach assuming second‐look surgery and $22,290 with a CWD approach. CWU and CWD generated a benefit of 17.11 and 17.30 QALYs, respectively. The incremental cost‐effectiveness ratio for CWU was $43,237 per QALY. The Monte Carlo PSA validated the base case scenario. Using a standard $50,000 willingness‐to‐pay threshold, CWD was the more cost‐effective approach and was selected 54.8% of the time by the simulation.

Conclusion

Both CWU and CWD were found to be cost‐effective, with CWD being cost‐effective 54.8% of the time at a WTP threshold of $50,000. The assumptions used in the analysis were validated by the results of 1‐way and PSA.