bluuebunny/crossref_metadata_2025 huggingface dataset:
Particle Microphysical Parameters and the Complex Refractive Index from 3β + 2α HSRL/Raman Lidar Measurements: Conditions of Accurate Retrieval, Retrieval Uncertainties and Constraints to Suppress the Uncertainties
Authors: Kolgotin Alexei , Müller Detlef , Romanov Anton
Published: July 2023

We study retrieval methods in regard to their potential to accurately retrieve particle microphysical parameters (PMP) from 3β + 2α HSRL/Raman lidar measurements. PMPs estimated with these methods are number, surface-area and volume concentrations, the effective radius, and complex refractive index of the investigated particle size distribution (PSD). The 3β + 2α optical data are particle backscatter coefficients at 355, 532 and 1064 nm and extinction coefficients at 355 and 532 nm. We present results that are fundamental for our understanding of how uncertainties of the optical data convert into uncertainties of PMPs. PMPs can only be retrieved with preset accuracy if the input optical data are accurate to at least eight significant digits, i.e., 10−6%. Such measurement accuracy cannot be achieved by currently existing lidar measurement techniques and the fact that atmospheric conditions are not static during lidar observations. Our analysis of the results derived with the novel approach shows that (a) the uncertainty of the retrieved surface-area concentration increases proportionally to the measurement uncertainty of the extinction coefficient at 355 nm, (b) the uncertainty of the effective radius is inversely proportional to the measurement uncertainty of the extinction-related Ångström exponent, (c) the uncertainty of volume concentration is close to the one of the effective radius, and (d) the uncertainty of number concentration is proportional to the inverse of the square value of the uncertainty of the effective radius. The complex refractive index (CRI) cannot be estimated without introducing extra constraints, even if measurement uncertainties of the optical data are as low as 1−3%. We tested constraints and their impact on the solution space, and in how far these constraints could allow us to restrict the retrieval uncertainties. For example, we used information about relative humidity that can be measured with Raman lidar. Relative humidity is an important piece of information that allows for more accurate aerosol typing and thus plays a vital role in any kind of aerosol characterization. The measurement example we used in this study shows that such a constraint can reduce the retrieval uncertainty of single scattering albedo (SSA) to as low as ±0.01–±0.025 (at 532 nm), on the condition that the uncertainty of the input optical data stays below 15%. The results will be used for uncertainty analysis of data products provided by future versions of the Tikhonov Advanced Regularization Algorithm (TiARA). This algorithm has evolved into a standard tool for the derivation of microphysical particle properties from multiwavelength High-Spectral-Resolution Lidar (HSRL)/Raman lidar operated in Europe, East Asia, and the US.
Biomechanical Characterisation of Thoracic Ascending Aorta with Preserved Pre-Stresses
Authors: Parikh Shaiv , Moerman Kevin , Ramaekers Mitch , Schalla Simon , Bidar Elham , Delhaas Tammo , Reesink Koen , Huberts Wouter
Published: July 2023

Mechanical properties of an aneurysmatic thoracic aorta are potential markers of future growth and remodelling and can help to estimate the risk of rupture. Aortic geometries obtained from routine medical imaging do not display wall stress distribution and mechanical properties. Mechanical properties for a given vessel may be determined from medical images at different physiological pressures using inverse finite element analysis. However, without considering pre-stresses, the estimation of mechanical properties will lack accuracy. In the present paper, we propose and evaluate a mechanical parameter identification technique, which recovers pre-stresses by determining the zero-pressure configuration of the aortic geometry. We first validated the method on a cylindrical geometry and subsequently applied it to a realistic aortic geometry. The verification of the assessed parameters was performed using synthetically generated reference data for both geometries. The method was able to estimate the true mechanical properties with an accuracy ranging from 98% to 99%.
The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential
Authors: Yang Fengguang , Ma Jinglin , Zhu Daxue , Wang Zhaoheng , Li Yanhu , He Xuegang , Zhang Guangzhi , Kang Xuewen
Published: July 2023

S100A6, also known as calcyclin, is a low-molecular-weight Ca2+-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.
Design of a Multi-Mode Mechanical Finger Based on Linkage and Tendon Fusion Transmission
Authors: Zhang Yi , Zhao Qian , Deng Hua , Xu Xiaolei
Published: July 2023

Today, most humanoid mechanical fingers use an underactuated mechanism driven by linkages or tendons, with only a single and fixed grasping trajectory. This paper proposes a new multi-mode humanoid finger mechanism based on linkage and tendon fusion transmission, which is embedded with an adjustable-length tendon mechanism to achieve three types of grasping mode. The structural parameters of the mechanism are optimized according to the kinematic and static models. Furthermore, a discussion was conducted on how to set the speed ratio of the linkage driving motor and the tendon driving motor to adjust the length and tension of the tendon, in order to achieve the switching of the shape-adaptive, coupled-adaptive, and variable coupling-adaptive grasping modes. Finally, the multi-mode functionality of the proposed finger mechanism was verified through multiple grasping experiments.
Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
Authors: Bendre Akhilesh , Hegde Vinayak , Ajeya Kanalli V. , Thagare Manjunatha Subrahmanya , Somasekhara Derangula , Nadumane Varalakshmi K. , Kant Krishna , Jung Ho-Young , Hung Wei-Song , Kurkuri Mahaveer D.
Published: July 2023

Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used materials for this purpose are metal—organic frameworks (MOFs). MOFs possess many properties, including their high surface area and the possibility for the addition of functional surface moieties, that make them ideal drug delivery vehicles. Such properties can be further improved by combining different materials (such as metals or ligands) and utilizing various synthesis techniques. In this work, the microfluidic technique is used to synthesize Zeolitic Imidazole Framework-67 (ZIF-67) containing cobalt ions as well as its bimetallic variant with cobalt and zinc as ZnZIF-67 to be subsequently loaded with diclofenac sodium and incorporated into sodium alginate beads for sustained drug delivery. This study shows the utilization of a microfluidic approach to synthesize MOF variants. Furthermore, these MOFs were incorporated into a biopolymer (sodium alginate) to produce a reliable DDS which can perform sustained drug releases for up to 6 days (for 90% of the full amount released), whereas MOFs without the biopolymer showed sudden release within the first day.
Exploring the Potential Applications of Engineered Borophene in Nanobiosensing and Theranostics
Authors: Srivastava Ananya , Dkhar Daphika S. , Singh Nandita , Azad Uday Pratap , Chandra Pranjal
Published: July 2023

A monolayer of boron known as borophene has emerged as a novel and fascinating two-dimensional (2D) material with exceptional features, such as anisotropic metallic behavior and supple mechanical and optical capabilities. The engineering of smart functionalized opto-electric 2D materials is essential to obtain biosensors or biodevices of desired performance. Borophene is one of the most emerging 2D materials, and owing to its excellent electroactive surface area, high electron transport, anisotropic behavior, controllable optical and electrochemical properties, ability to be deposited on thin films, and potential to create surface functionalities, it has recently become one of the sophisticated platforms. Despite the difficulty of production, borophene may be immobilized utilizing chemistries, be functionalized on a flexible substrate, and be controlled over electro-optical properties to create a highly sensitive biosensor system that could be used for point-of-care diagnostics. Its electrochemical properties can be tailored by using appropriate nanomaterials, redox mediators, conducting polymers, etc., which will be quite useful for the detection of biomolecules at even trace levels with a high sensitivity and less detection time. This will be quite helpful in developing biosensing devices with a very high sensitivity and with less response time. So, this review will be a crucial foundation as we have discussed the basic properties, synthesis, and potential applications of borophene in nanobiosensing, as well as therapeutic applications.
Point-of-Care Diagnostic Devices for Detection of Escherichia coli O157:H7 Using Microfluidic Systems: A Focused Review
Authors: Abbas Naseem , Song Sehyeon , Chang Mi-Sook , Chun Myung-Suk
Published: July 2023

Bacterial infections represent a serious and global threat in modern medicine; thus, it is very important to rapidly detect pathogenic bacteria, such as Escherichia coli (E. coli) O157:H7. Once treatments are delayed after the commencement of symptoms, the patient’s health quickly deteriorates. Hence, real-time detection and monitoring of infectious agents are highly critical in early diagnosis for correct treatment and safeguarding public health. To detect these pathogenic bacteria, many approaches have been applied by the biosensors community, for example, widely-used polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA), culture-based method, and adenosine triphosphate (ATP) bioluminescence. However, these approaches have drawbacks, such as time-consumption, expensive equipment, and being labor-intensive, making it critical to develop ultra-sensitive and highly selective detection. The microfluidic platform based on surface plasmon resonance (SPR), electrochemical sensing, and rolling circle amplification (RCA) offers proper alternatives capable of supplementing the technological gap for pathogen detection. Note that the microfluidic biochip allows to develop rapid, sensitive, portable, and point-of-care (POC) diagnostic tools. This review focuses on recent studies regarding accurate and rapid detection of E. coli O157:H7, with an emphasis on POC methods and devices that complement microfluidic systems. We also examine the efficient whole-body detection by employing antimicrobial peptides (AMPs), which has attracted growing attention in many applications.
C-Reactive Protein Levels and Cognitive Decline following Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
Authors: Wang Likun , Yang Lining , Liu Haiyan , Pu Juncai , Li Yi , Tang Lu , Chen Qing , Pu Fang , Bai Dingqun
Published: July 2023

Cognitive decline (CD) is devastating with a high incidence in patients after stroke. Although some studies have explored underlying associations between C-reactive protein (CRP) levels and cognitive decline after stroke, consistent results have not been obtained. Therefore, this meta-analysis aimed to explore whether or not higher levels of C-reactive proteins were associated with an increased risk of cognitive decline after stroke. To this end, PubMed, Embase, the Cochrane Library, and Web of Science were searched for eligible studies, and pooled effect sizes from eligible studies were calculated using random effect models. Furthermore, subgroups were established and meta-regression analyses were performed to explain the causes of heterogeneity. Eventually, nine studies with 3893 participants were included. Our statistical results suggested that the concentrations of peripheral CRP may be significantly increased for CD patients after stroke, compared to those of non-CD patients. Subgroup analyses showed that CRP was higher in CD than that in non-CD patients when the mini-mental state examination was used. A higher level of CRP in the acute phase of ischemic stroke may suggest an increased risk of CD after stroke. However, these results should be cautiously interpreted because of the limited sample sizes and the diversity of potential confounders in the studies included in this meta-analysis.
Lattice Distortion in Co3O4/Mn3O4-Guided Synthesis via Carbon Nanotubes for Efficient Lean Methane Combustion
Authors: Wei Xinfang , Yang Ke , Zhu Qinghan , Li Jinlong , Qi Jian , Wang Haiwang
Published: July 2023

In this paper, with the synergistic effect of C, Co and O elements, and with a one-dimensional carbon nanotube (CNT) as the structure guide agent, a two-dimensional Co3O4 nano-sheet with high catalytic activity was prepared, and its catalytic activity was further improved by adding a manganese element. By controlling the annealing time, a two-dimensional Co3O4-based nano-sheet with a regular arrangement of atoms on the surface was gradually formed during the oxidation process of CNT. Then, the lattice distortion of Co3O4 was caused by doping manganese. The interaction between Mn and Co promotes the cycle capacity of Mn/Co redox pair and the generation of reactive oxygen species, which is conducive to an improvement in catalytic activity. Finally, under different catalytic conditions, the 2D Co3O4-based catalysts all showed stable catalytic performances, among which methane flow rate had a great influence. When the airspeed was controlled within the range of 42,000 mL·g−1·h−1, the methane conversion rate could still reach 90% (450 °C).
To Be or Not to Be an Ion Channel: Cryo-EM Structures Have a Say
Authors: Chen Gui-Lan , Li Jian , Zhang Jin , Zeng Bo
Published: July 2023

Ion channels are the second largest class of drug targets after G protein-coupled receptors. In addition to well-recognized ones like voltage-gated Na/K/Ca channels in the heart and neurons, novel ion channels are continuously discovered in both excitable and non-excitable cells and demonstrated to play important roles in many physiological processes and diseases such as developmental disorders, neurodegenerative diseases, and cancer. However, in the field of ion channel discovery, there are an unignorable number of published studies that are unsolid and misleading. Despite being the gold standard of a functional assay for ion channels, electrophysiological recordings are often accompanied by electrical noise, leak conductance, and background currents of the membrane system. These unwanted signals, if not treated properly, lead to the mischaracterization of proteins with seemingly unusual ion-conducting properties. In the recent ten years, the technical revolution of cryo-electron microscopy (cryo-EM) has greatly advanced our understanding of the structures and gating mechanisms of various ion channels and also raised concerns about the pore-forming ability of some previously identified channel proteins. In this review, we summarize cryo-EM findings on ion channels with molecular identities recognized or disputed in recent ten years and discuss current knowledge of proposed channel proteins awaiting cryo-EM analyses. We also present a classification of ion channels according to their architectures and evolutionary relationships and discuss the possibility and strategy of identifying more ion channels by analyzing structures of transmembrane proteins of unknown function. We propose that cross-validation by electrophysiological and structural analyses should be essentially required for determining molecular identities of novel ion channels.
Src-Dependent NM2A Tyrosine Phosphorylation Regulates Actomyosin Remodeling
Authors: Brito Cláudia , Pereira Joana M. , Mesquita Francisco S. , Cabanes Didier , Sousa Sandra
Published: July 2023

Non-muscle myosin 2A (NM2A) is a key cytoskeletal enzyme that, along with actin, assembles into actomyosin filaments inside cells. NM2A is fundamental for cell adhesion and motility, playing important functions in different stages of development and during the progression of viral and bacterial infections. Phosphorylation events regulate the activity and the cellular localization of NM2A. We previously identified the tyrosine phosphorylation of residue 158 (pTyr158) in the motor domain of the NM2A heavy chain. This phosphorylation can be promoted by Listeria monocytogenes infection of epithelial cells and is dependent on Src kinase; however, its molecular role is unknown. Here, we show that the status of pTyr158 defines cytoskeletal organization, affects the assembly/disassembly of focal adhesions, and interferes with cell migration. Cells overexpressing a non-phosphorylatable NM2A variant or expressing reduced levels of Src kinase display increased stress fibers and larger focal adhesions, suggesting an altered contraction status consistent with the increased NM2A activity that we also observed. We propose NM2A pTyr158 as a novel layer of regulation of actomyosin cytoskeleton organization.
The Gut–Brain Axis as a Therapeutic Target in Multiple Sclerosis
Authors: Buga Ana Maria , Padureanu Vlad , Riza Anca-Lelia , Oancea Carmen Nicoleta , Albu Carmen Valeria , Nica Alexandru Dan
Published: July 2023

The CNS is very susceptible to oxidative stress; the gut microbiota plays an important role as a trigger of oxidative damage that promotes mitochondrial dysfunction, neuroinflammation, and neurodegeneration. In the current review, we discuss recent findings on oxidative-stress-related inflammation mediated by the gut–brain axis in multiple sclerosis (MS). Growing evidence suggests targeting gut microbiota can be a promising strategy for MS management. Intricate interaction between multiple factors leads to increased intra- and inter-individual heterogeneity, frequently painting a different picture in vivo from that obtained under controlled conditions. Following an evidence-based approach, all proposed interventions should be validated in clinical trials with cohorts large enough to reach significance. Our review summarizes existing clinical trials focused on identifying suitable interventions, the suitable combinations, and appropriate timings to target microbiota-related oxidative stress. Most studies assessed relapsing–remitting MS (RRMS); only a few studies with very limited cohorts were carried out in other MS stages (e.g., secondary progressive MS–SPMS). Future trials must consider an extended time frame, perhaps starting with the perinatal period and lasting until the young adult period, aiming to capture as many complex intersystem interactions as possible.
Epigenetic Reprogramming in Mice and Humans: From Fertilization to Primordial Germ Cell Development
Authors: Singh Aditi , Rappolee Daniel A. , Ruden Douglas M.
Published: July 2023

In this review, advances in the understanding of epigenetic reprogramming from fertilization to the development of primordial germline cells in a mouse and human embryo are discussed. To gain insights into the molecular underpinnings of various diseases, it is essential to comprehend the intricate interplay between genetic, epigenetic, and environmental factors during cellular reprogramming and embryonic differentiation. An increasing range of diseases, including cancer and developmental disorders, have been linked to alterations in DNA methylation and histone modifications. Global epigenetic reprogramming occurs in mammals at two stages: post-fertilization and during the development of primordial germ cells (PGC). Epigenetic reprogramming after fertilization involves rapid demethylation of the paternal genome mediated through active and passive DNA demethylation, and gradual demethylation in the maternal genome through passive DNA demethylation. The de novo DNA methyltransferase enzymes, Dnmt3a and Dnmt3b, restore DNA methylation beginning from the blastocyst stage until the formation of the gastrula, and DNA maintenance methyltransferase, Dnmt1, maintains methylation in the somatic cells. The PGC undergo a second round of global demethylation after allocation during the formative pluripotent stage before gastrulation, where the imprints and the methylation marks on the transposable elements known as retrotransposons, including long interspersed nuclear elements (LINE-1) and intracisternal A-particle (IAP) elements are demethylated as well. Finally, DNA methylation is restored in the PGC at the implantation stage including sex-specific imprints corresponding to the sex of the embryo. This review introduces a novel perspective by uncovering how toxicants and stress stimuli impact the critical period of allocation during formative pluripotency, potentially influencing both the quantity and quality of PGCs. Furthermore, the comprehensive comparison of epigenetic events between mice and humans breaks new ground, empowering researchers to make informed decisions regarding the suitability of mouse models for their experiments.
Antibiotic Consumption, Illness, and Maternal Sensitivity in Infants with a Disorganized Attachment
Authors: Fuertes Marina , Faria Anabela , Gonçalves Joana L. , Antunes Sandra , Dionisio Francisco
Published: July 2023

Prior research found an association between mother–infant attachment and antibiotic use. Ambivalent-attached infants are more likely to take antibiotics than other infants, and their mothers tend to be less sensitive to their needs than most. This finding is important because it shows the association between psychological processes, early relationships, and health outcomes. We aim to learn about children with high-risk attachment relationships, such as disorganized-attached infants. This study compares antibiotic use, infant–mother interactive behavior, and health indicators according to infant attachment patterns (including disorganized attachment). For this purpose, we observed mothers–infants’ interactive behavior in free play at nine months and infants’ attachment in the Ainsworth Strange Situation at twelve months. Participants included 77 girls and 104 boys (full-term and preterm) and their mothers. Paradoxically, mothers of disorganized-attached infants reported that their children were ill only 1.56 times on average, but 61% of their children used antibiotics in the first nine months. The other mothers reported that their children were sick 5.73 times on average, but only 54% of their children used antibiotics in the same period. Infants with disorganized attachment had mothers who were more literate and less sensitive. These results add to a body of research that shows that early high-risk relationships affect children’s lives at multiple levels.
Different Cooling Histories of Ultrahigh-Temperature Granulites Revealed by Ti-in-Quartz: An Electron Microprobe Approach
Authors: Zhang Di , Chen Yi , Mao Qian , Jiao Shujuan , Su Bin , Chen Si , Sein Kyaing
Published: July 2023

The cooling history of granulite is crucial to understanding tectonic scenarios of the continental crust. Ti-in-quartz, a useful indicator of temperature, can decipher the thermal evolution of crustal rocks. Here we apply the Ti-in-quartz (TitaniQ) thermometer to ancient ultrahigh-temperature (UHT) granulites from the Khondalite Belt (KB) in the North China Craton (NCC) and young UHT granulites from the Mogok Metamorphic Belt (MMB), Myanmar. Ti content in quartz was analyzed using a highly precise method constructed in a CAMECA SXFive electron probe microanalyzer (EPMA). The granulites from the two localities show different quartz Ti contents with a constant deforced beam of 10 μm. Matrix quartz and quartz inclusions from the NCC granulites have 57–241 ppm and 65–229 ppm, respectively, corresponding to the TitaniQ temperatures of 653–810 °C and 666–807 °C. The calculated temperatures are significantly lower than the peak temperatures (850–1096 °C) obtained by other methods, due to the formation of abundant rutile exsolution rods in quartz during cooling. Thus, the low calculated temperatures for the NCC granulites reflect a cooling state near or after the exsolution of rutile from quartz, most likely caused by a slow cooling process. However, the matrix quartz from the MMB granulites is exsolution-free and records higher Ti contents of 207–260 ppm and higher metamorphic temperatures of 894–926 °C, close to the peak UHT conditions. This feature indicates that the MMB granulites underwent rapid cooling to overcome Ti loss from quartz. Therefore, determining the amount of Ti loss from quartz by diffusion can provide new insight into the cooling behavior of UHT granulites. When a large deforced beam of 50 μm was used to cover the rutile rods, the matrix quartz in the KB granulites could also yield the TitaniQ temperatures above 900 °C. Thus, our new data suggest that the TitaniQ thermometer could be useful for revealing UHT conditions.
Mechanical Analysis and Testing of Conduction-Cooled Superconducting Magnet for Levitation Force Measurement Application
Authors: Liu Liyuan , Chen Wei , Zhuang Huimin , Chi Fei , Wang Gang , Zhang Gexiang , Jiang Jing , Yang Xinsheng , Zhao Yong
Published: July 2023

High-temperature superconductors have great potential for various engineering applications such as a flywheel energy storage system. The levitation force of bulk YBCO superconductors can be drastically increased by increasing the strength of the external field. Therefore, a 6T conduction-cooled superconducting magnet has been developed for levitation force measurement application. Firstly, to protect the magnet from mechanical damage, reliable stress analysis inside the coil is paramount before the magnet is built and tested. Therefore, a 1/4 two-dimensional (2D) axisymmetric model of the magnet was established, and the mechanical stress in the whole process of winding, cooling down and energizing of the magnet was calculated. Then, the charging, discharging, and preliminary levitation force performance tests were performed to validate the operating stability of the magnet. According to the simulation results, the peak stresses of all coil models are within the allowable value and the winding maintains excellent mechanical stability in the superconducting magnet. The test results show that the superconducting magnet can be charged to its desired current of 150 A without quenching and maintain stable operation during the charging and discharging process. What is more, the superconducting magnet can meet the requirements for the levitation force measurement of both low magnetic field and high magnetic field.
An Efficient Framework for Autonomous UAV Missions in Partially-Unknown GNSS-Denied Environments
Authors: Mugnai Michael , Teppati Losé Massimo , Herrera-Alarcón Edwin , Baris Gabriele , Satler Massimo , Avizzano Carlo
Published: July 2023

Nowadays, multirotors are versatile systems that can be employed in several scenarios, where their increasing autonomy allows them to achieve complex missions without human intervention. This paper presents a framework for autonomous missions with low-cost Unmanned Aerial Vehicles (UAVs) in Global Navigation Satellite System-denied (GNSS-denied) environments. This paper presents hardware choices and software modules for localization, perception, global planning, local re-planning for obstacle avoidance, and a state machine to dictate the overall mission sequence. The entire software stack has been designed exploiting the Robot Operating System (ROS) middleware and has been extensively validated in both simulation and real environment tests. The proposed solution can run both in simulation and in real-world scenarios without modification thanks to a small sim-to-real gap with PX4 software-in-the-loop functionality. The overall system has competed successfully in the Leonardo Drone Contest, an annual competition between Italian Universities with a focus on low-level, resilient, and fully autonomous tasks for vision-based UAVs, proving the robustness of the entire system design.
Transcriptomic Response to Drought Stress in Populus davidiana Dode
Authors: Yang Meng , Wang Lili , Wang Xinyu , Li Yijie , Huang Haijiao
Published: July 2023

Plants are often exposed to drought stress, and decreases in the soil water content can prevent plants from reaching their full genetic potential. Populus davidiana Dode belongs to the genus Populus, and it is a temperate deciduous tree that is cold and drought tolerant. To investigate the mechanism of P. davidiana response to drought stress, transcriptome analysis was performed on drought and control treatments of P. davidiana. We identified 10230 differentially expressed genes (DEGs). Most DEGs were enriched in pathways related to transcriptional regulation and hormone signal transduction, ROS metabolism, lignin synthesis, and the sugar metabolism process in two contrasting groups. Compared with the control condition, soluble sugars, proline, and POD activity were all increased under drought stress. In addition, Na+, K+, and Ca2+ were all higher under drought stress than in the control. These results not only revealed the mechanism of tolerance to drought stress in P. davidiana, but also promoted the development and application of drought-tolerant genetic resources in P. davidiana.
An Effective Method for Computing the Least-Cost Path Using a Multi-Resolution Raster Cost Surface Model
Authors: Tang Qiuling , Dou Wanfeng
Published: July 2023

Calculating the least-cost path (LCP) is a fundamental operation in raster-based geographic information systems (GIS). The LCP is applied to raster cost surfaces, in which it determines the most cost-effective path. Increasing the raster resolution results in a longer computation time to obtain LCP. This paper proposes a method for calculating the LCP using a multi-resolution raster cost surface model to enhance computational performance for large-scale grids. The original raster cost surface is progressively downsampled to generate grids of decreasing resolutions. Subsequently, the path is determined on the low-resolution raster. By performing operations such as filtering directional points and mapping path points, the final path on the high-resolution raster can be obtained. The method enables a parallel computation of paths. Therefore, it significantly improves the efficiency for synthetic raster cost surfaces with continuous or discrete characteristics, as well as for raster cost surfaces generated from real terrain datasets, while also providing an end-to-end path output. The experiments show that 80% of the results are very close to the original LCP, and the accuracy of the remaining paths falls within an acceptable range. At the same time, our method greatly improves the efficiency of path solving on a large-scale raster, fulfilling practical application requirements.
Assessing Cognitive Skills in Early Childhood Education Using a Bilingual Early Language Learner Assessment Tool
Authors: Tan Mei , Kilani Hechmi , Markov Ilia , Hein Sascha , Grigorenko Elena L.
Published: July 2023

In this article, we propose that basic cognitive skills may be fostered and assessed in early childhood educational (pre-K) settings using a technology-based approach to assessment. BELLA (Bilingual English Language Learner Assessment), designed for use with both monolingual (English or Spanish speaking) and bilingual (English and Spanish speaking) children, is designed to attend to cognitive skill development in addition to (pre-)academic knowledge. Specifically, BELLA assesses analytical, creative, and practical thinking in 3–5-year-old children through unique item content and delivery. BELLA is among the first tablet-based pre-K assessments designed to assess cognitive skills needed for the era of the Anthropocene.
Beta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: A Pilot Study
Authors: Escalona José , Soto Dagoberto , Oviedo Vanessa , Rivas Elizabeth , Severino Nicolás , Kattan Eduardo , Andresen Max , Bravo Sebastián , Basoalto Roque , Bachmann María Consuelo , Wong Kwok-Yin , Pavez Nicolás , Bruhn Alejandro , Bugedo Guillermo , Retamal Jaime
Published: July 2023

Different techniques have been proposed to measure antibiotic levels within the lung parenchyma; however, their use is limited because they are invasive and associated with adverse effects. We explore whether beta-lactam antibiotics could be measured in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and correlated with the concentration of antibiotics measured from bronchoalveolar lavage (BAL). We designed an observational study in patients undergoing mechanical ventilation, which required a BAL to confirm or discard the diagnosis of pneumonia. We measured and correlated the concentration of beta-lactam antibiotics in plasma, epithelial lining fluid (ELF), and exhaled breath condensate collected from HMEFs. We studied 12 patients, and we detected the presence of antibiotics in plasma, ELF, and HMEFs from every patient studied. The concentrations of antibiotics were very heterogeneous over the population studied. The mean antibiotic concentration was 293.5 (715) ng/mL in plasma, 12.3 (31) ng/mL in ELF, and 0.5 (0.9) ng/mL in HMEF. We found no significant correlation between the concentration of antibiotics in plasma and ELF (R2 = 0.02, p = 0.64), between plasma and HMEF (R2 = 0.02, p = 0.63), or between ELF and HMEF (R2 = 0.02, p = 0.66). We conclude that beta-lactam antibiotics can be detected and measured from the exhaled breath condensate accumulated in the HMEF from mechanically ventilated patients. However, no correlations were observed between the antibiotic concentrations in HMEF with either plasma or ELF.
Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules—An Insight into the Release Kinetics
Authors: Pereira Luís , Ferreira Frederico Castelo , Pires Filipa , Portugal Carla A. M.
Published: July 2023

This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an external magnetic field. Magnetic-responsive liposomal hydrogel delivery systems were prepared by encapsulation of 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) multilayered vesicles (MLVs) loaded with ferulic acid (FA), i.e., DPPC:FA liposomes, into gelatin hydrogel membranes containing dispersed iron oxide nanoparticles (MNPs), i.e., magnetic-responsive gelatin. The FA release mechanisms and kinetics from magnetic-responsive liposomal gelatin were studied and compared with those obtained with conventional drug delivery systems, e.g., free liposomal suspensions and hydrogel matrices, to access the effect of liposome entrapment and magnetic field on FA delivery. FA release from liposomal gelatin membranes was well described by the Korsmeyer–Peppas model, indicating that FA release occurred under a controlled diffusional regime, with or without magnetic stimulation. DPPC:FA liposomal gelatin systems provided smoother controlled FA release, relative to that obtained with the liposome suspensions and with the hydrogel platforms, suggesting the promising application of liposomal hydrogel systems in longer-term therapeutics. The magnetic field, with low intensity (0.08 T), was found to stimulate the FA release from magnetic-responsive liposomal gelatin systems, increasing the release rates while shifting the FA release to a quasi-Fickian mechanism. The magnetic-responsive liposomal hydrogels developed in this work offer the possibility to magnetically activate drug release from these liposomal platforms based on a non-thermal related delivery strategy, paving the way for the development of novel and more efficient applications of MLVs and liposomal delivery systems in biomedicine.
Rupture and Response—Rorty, Cavell, and Rancière on the Role of the Poetic Powers of Democratic Citizens in Overcoming Injustices and Oppression
Authors: Räber Michael
Published: July 2023

In this paper, I discuss the importance of practices of disidentification and imagination for democratic progress and change. To this end, I bring together certain aspects of Stanley Cavell’s and Richard Rorty’s reflections on democracy, aesthetics, and morality with Jacques Rancière’s account of the importance of appearance for democratic participation. With Rancière, it can be shown that any public–political order always involves the possibility (and often the reality) of exclusion or oppression of those who “have no part” in the current order through a particular order of perceptibility, and that democratic action, therefore, requires rupturing acts of political agency on the part of self-proclaimed political actors through which disidentifications and constructions of difference against such existing orders become possible. With Cavell and Rorty, in turn, it can be shown that these rupturing moments, in order to actually become politically effective, require a responsive disposition and a willingness to engage in practices of imagination on the part of those who occupy dominant positions on existing orders, insofar as they must acknowledge the expression of others’ sense of injustice. The upshot of my discussion is that a comprehensive account of the aesthetic dimension of democratic politics must simultaneously address the interruption of political action on the one hand and responsiveness on the other, and that Rancière and the neo-pragmatists Rorty and Cavell complement each other insofar as they illuminate the blind spots of their respective approaches.
Application of Green Polymeric Nanocomposites for Enhanced Oil Recovery by Spontaneous Imbibition from Carbonate Reservoirs
Authors: Ahmadi Yaser , Ayari Mohamed Arselene , Olfati Meysam , Hosseini Seyyed Hossein , Khandakar Amith , Vaferi Behzad , Olazar Martin
Published: July 2023

This study experimentally investigates the effect of green polymeric nanoparticles on the interfacial tension (IFT) and wettability of carbonate reservoirs to effectively change the enhanced oil recovery (EOR) parameters. This experimental study compares the performance of xanthan/magnetite/SiO2 nanocomposites (NC) and several green materials, i.e., eucalyptus plant nanocomposites (ENC) and walnut shell ones (WNC) on the oil recovery with performing series of spontaneous imbibition tests. Scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDAX), and BET (Brunauer, Emmett, and Teller) surface analysis tests are also applied to monitor the morphology and crystalline structure of NC, ENC, and WNC. Then, the IFT and contact angle (CA) were measured in the presence of these materials under various reservoir conditions and solvent salinities. It was found that both ENC and WNC nanocomposites decreased CA and IFT, but ENC performed better than WNC under different salinities, namely, seawater (SW), double diluted salted (2 SW), ten times diluted seawater (10 SW), formation water (FW), and distilled water (DIW), which were applied at 70 °C, 2000 psi, and 0.05 wt.% nanocomposites concentration. Based on better results, ENC nanofluid at salinity concentrations of 10 SW and 2 SW ENC were selected for the EOR of carbonate rocks under reservoir conditions. The contact angles of ENC nanocomposites at the salinities of 2 SW and 10 SW were 49 and 43.4°, respectively. Zeta potential values were −44.39 and −46.58 for 2 SW and 10 SW ENC nanofluids, which is evidence of the high stability of ENC nanocomposites. The imbibition results at 70 °C and 2000 psi with 0.05 wt.% ENC at 10 SW and 2 SW led to incremental oil recoveries of 64.13% and 60.12%, respectively, compared to NC, which was 46.16%.
Variated Cultural Imagery of the Daodejing in the German-Speaking World Based on “Foreignization”: The Case of Dao and De
Authors: Tang Xue
Published: July 2023

“Foreignization” (taguohua, 他国化) is an important concept in the Variation Theory of Comparative Literature. Through the collision, fusion and heterogeneous absorption of cross-heterogeneous cultural exchanges, the culture and discourse principles of one country are adapted through localization by the receiving country, resulting in what this theory calls “foreignization”. Global Laozegetics continues its traditional interpretive-oriented stance by examining translations of the Daodejing from a Laozegetics perspective, demonstrating a new development in the study of Laozi’s doctrine. Thus, there is a need to explore new perspectives in the research on the German translations of the Daodejing. Taking the cultural imagery Dao and De as examples, this paper explores the background and causes of “foreignization” in German translations of the Daodejing and its impact on the dissemination of Laozi’s doctrine in the German-speaking world, summarizing its formation path and possible problems, with the goal of shedding light on the overseas dissemination of Chinese classics represented by the Daodejing.
Monitoring Surface Subsidence Using Distributed Scatterer InSAR with an Improved Statistically Homogeneous Pixel Selection Method in Coalfield Fire Zones
Authors: Tian Zeming , Fan Hongdong , Cao Fei , He Long
Published: July 2023

Statistically homogeneous pixel (SHP) selection is an important process in the distributed scatterer interferometric synthetic aperture radar (DS-InSAR) approach. However, prevalent methods struggle to appropriately balance the efficiency and accuracy of selection. To solve this problem, the authors of this study improved the Hypothesis Test of Confidence Interval (HTCI) to propose an adaptive method to select the level of saliency and confidence interval for the HTCI, called Adp-HTCI. The proposed method can accurately select homogeneous pixels while inheriting the high efficiency of the HTCI. Once homogeneous pixels have been chosen, the eigenvalue decomposition of the covariance matrix is used to optimize their phase and perform temporal processing. We used the proposed method along with data on 31 scenes from the Sentinel-1 satellite from 2 June 2021 to 28 May 2022 to monitor the deformation of the surface of the fire zone in the Sikeshu coalfield. The selection results of homogeneous pixels indicate that the proposed Adp-HTCI algorithm can increase the number of selected homogeneous pixels while ensuring the accuracy of the selection results, thereby enhancing the estimation accuracy and reliability of subsequent parameter solving. The DS-InSAR results showed that the cumulative maximum subsidence in the study area within a year reached—138 mm and the point density used by the DS-InSAR approach was 17.28 times higher than that used by the StaMPS approach. The results of cross-analysis with the results of StaMPS verified the accuracy of the DS-InSAR-based approach.
Correlates of Rates and Treatment Readiness for Depressive Symptoms, Pain, and Fatigue in Hemodialysis Patients: Results from the TĀCcare Study
Authors: Devaraj Susan M. , Roumelioti Maria-Eleni , Yabes Jonathan G. , Schopp Mary , Erickson Sarah , Steel Jennifer L. , Rollman Bruce L. , Weisbord Steven D. , Unruh Mark , Jhamb Manisha
Published: July 2023

Key Points

Lower neighborhood walkability was associated with higher depressive symptoms and fatigue and younger age with depressive symptoms.

Depressive symptoms, pain, and fatigue were frequently reported, often occurred together, and were often not all already treated.

Patients with a higher symptom burden and men may be more likely to be ready to seek treatment for depressive symptoms, pain, or fatigue.

Background

Patients on hemodialysis (HD) often experience clinically significant levels of pain, fatigue, and depressive symptoms. We explored potential sociodemographic differences in symptom burden, current treatment, and readiness to seek treatment for these symptoms in patients screened for the TĀCcare trial.

Methods

In-center HD patients from Pennsylvania and New Mexico were screened for fatigue (≥5 on 0–10-point Likert scale), pain (Likert scale ≥4), depressive symptoms (≥10 Patient Health Questionnaire-9), and readiness to seek treatment (5–item Stages of Behavior Change questionnaire). Symptom burden and treatment status by sociodemographic factors were evaluated using chi square, Fisher exact tests, and logistic regression models.

Results

From March 2018 to December 2021, 506 of 896 (57%) patients screened met eligibility criteria and completed the symptom screening (mean age 60±13.9 years, 44% female, 17% Black, 25% American Indian, and 25% Hispanics). Of them, 77% screened positive for ≥1 symptom and 35% of those were receiving treatment for ≥1 of these symptoms. Pain, fatigue, and depressive symptom rates were 52%, 64%, and 24%, respectively. Age younger than 65 years was associated with a higher burden of depressive symptoms, pain, and reporting ≥1 symptom (P<0.05). The percentage of patients ready to seek treatment increased with symptom burden. More men reported readiness to seek treatment (85% versus 68% of women, P<0.001). Among those with symptoms and treatment readiness, income was inversely associated with pain (>$60,000/yr: odds ratio [OR]=0.16, confidence interval [CI]=0.03 to 0.76) and living in less walkable neighborhoods with more depressive symptoms (OR= 5.34, CI=1.19 to 24.05) and fatigue (OR= 5.29, CI=1.38 to 20.33).

Conclusions

Pain, fatigue, and depressive symptoms often occurred together, and younger age, less neighborhood walkability, and lower income were associated with a higher burden of symptoms in HD patients. Male patients were less likely to be receiving treatment for symptoms. These findings could inform priority HD patient symptom identification and treatment targets.
ZÂKİR VE MÜRAİ: ZİKİR AÇISINDAN RİYA KAVRAMINA FARKLI BİR YAKLAŞIM
Authors: DEMİRDİL MAHMUT , YILDIZ MUHAMMED ALİ
Published: July 2023

A person can be in some states during his worship or dhikr due to the situation he is in. Those who witness these behaviors may perceive the situation as exaggeration and showing off. It is seen that especially those who are in such situations are given adjectives such as murai (hypocrite) and mutazehhid (non ascetic) as a religious concept. The subject of hypocrisy has a wide scope in terms of its different reflections. For this reason, our study is limited to the approaches to murailik (hypocrisy) in particular dhikr. Scholars have expressed their views in detail in their works so that people can get rid of this disease. In particular, the danger of this thought or intention has been mentioned as well as a share of realization. The aim of our research is to examine the perception of hypocrisy/müraism that may occur in humans in the face of a number of cases during dhikr. Of course, there are studies on the details of the hypocrisy issue. However, a detached study could not be seen in which the issue we examined was examined through the relevant hadiths. Therefore, it is aimed to draw attention to new research. In our study, the subject resources were combined with the scanning model using qualitative research method. It has been seen that the hadiths that constitute the framework of our research have a mixed health status. However, the weakness of these narrations in the category of weak hadith is not advanced; It was thought that it should be addressed in the study because it encourages goodness. Keywords: Mysticism, Hypocrisy, Hypocrite, Dhikr, Attraction, Non Ascetic.