bluuebunny/crossref_metadata_2025 huggingface dataset:
Traditional Chinese Medicine Ginseng Dingzhi Decoction Ameliorates Myocardial Fibrosis and High Glucose-Induced Cardiomyocyte Injury by Regulating Intestinal Flora and Mitochondrial Dysfunction
Authors: Wang Junyan , Chen Peiwen , Cao Qiuyu , Wang Wei , Chang Xing
Published: March 2022

Myocardial fibrosis refers to the pathological changes of heart structure and morphology caused by various reasons of myocardial damage. It has become an important challenge in the later clinical treatment of acute myocardial infarction/ischemic cardiomyopathy or diabetes complicated with heart failure. Ginseng Dingzhi Decoction (GN), a Chinese herbal medicine, can reduce heart failure and protect cardiomyocytes. We infer that this may be related to the interaction with intestinal microbiota and mitochondrial homeostasis. The regulatory mechanism of GN on gut microbiota and mitochondria has not yet been elucidated. The intestinal microbiota was analyzed by the 16S rRNA gene; the fecal samples were sequenced and statistically analyzed to determine the changes of microbiota in the phenotype of heart failure rats. In addition, GN can regulate the microbial population that increases the proportion of short-chain fatty acids and anti-inflammatory bacteria and reduces the proportion of conditional pathogens to diabetic phenotype. The results suggest that GN may improve myocardial injury by regulating intestinal flora. Our data also show that stress-type heart failure caused by TAC (transverse aortic constriction) is accompanied by severe cardiac hypertrophy, reduced cardiac function, redox imbalance, and mitochondrial dysfunction. However, the use of GN intervention can significantly reduce heart failure and myocardial hypertrophy, improve heart function and improve myocardial damage, and maintain the mitochondrial homeostasis and redox of myocardial cells under high glucose stimulation. Interestingly, through in vitro experiments after TMBIM6 siRNA treatment, the improvement effect of GN on cell damage and the regulation of mitochondrial homeostasis were eliminated. TMBIM6 can indirectly regulate mitophagy and mitochondrial homeostasis to attenuate myocardial damage and confirms the regulatory effect of GN on mitophagy and mitochondrial homeostasis. We further intervened cardiomyocytes in high glucose through metformin (MET) and GN combination therapy. Research data show that MET and GN combination therapy can improve the level of mitophagy and protect cardiomyocytes. Our findings provide novel mechanistic insights for the treatment of diabetes combined with myocardial injury (myocardial fibrosis) and provide a pharmacological basis for the study of the combination of Chinese medicine and conventional diabetes treatment drugs.
Modelling the Effect of the Interaction between Vaccination and Nonpharmaceutical Measures on COVID-19 Incidence
Authors: Canga Atsegine , Bidegain Gorka
Published: March 2022

Since December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly from Wuhan (China) across the globe, affecting more than 200 countries by mid-2021, with over 190 M reported cases and around 4 M fatalities. During the first year of the pandemic, affected countries implemented a variety of nonpharmaceutical interventions to control virus transmission. In December 2020, countries started administering several authorised vaccines under a limited supply scenario. In this context, the aim of this study was to develop a SEIR-type continuous-time deterministic disease model, to determine the impact of interaction between different vaccination scenarios and levels of protection measures on disease incidence. For this, the model incorporates (i) a protection measure including low (self-protection), medium (mobility limitation), high (closure of indoor facilities), and very high (lockdown) protection levels, (ii) quarantine for confirmed cases, and (iii) vaccination rate and efficacy of four types of vaccines (Pfizer, Moderna, Astra Zeneca, and Janssen). The model was verified and evaluated using the response timeline and vaccination strategies and rates in the Basque Country (N. Spain). Once the model performance was validated, different initial phase (when 30% of the population is vaccinated) vaccination scenarios were simulated, including (i) a realistic vaccine limited supply scenario and (ii) four potential full vaccine supply scenarios where a unique vaccine type is administered. Significant differences in disease prevalence and cumulative mortality were found between vaccination scenarios for low and medium-level protection measures. For high-level protection measures, any vaccine scenario is effective at limiting the virus transmission and disease mortality. The results obtained here may vary in further studies since there may be some unpredictable factors/covariates. With this in mind, the model here could be easily applied to other regions or countries, modifying the strategies implemented and initial conditions.
A Self-Adaptive Extragradient Algorithm for Solving Quasimonotone Variational Inequalities
Authors: Zhu Li-Jun , Yin Tzu-Chien
Published: March 2022

This article aims to research iterative schemes for searching a solution of a quasimonotone variational inequality in a Hilbert space. For solving this quasimonotone variational inequality, we propose an iterative procedure which combines a self-adaptive rule and the extragradient algorithm. We demonstrate that the procedure weakly converges to the solution of the investigated quasimonotone variational inequality provided the considered operator satisfies several additional conditions.
Research on the Propagation Characteristics of Negative News Information Based on Personalized Recommendation Algorithm
Authors: Li Shuting
Published: March 2022

This article will focus on how to reduce the negative information in the main theme report. Negative information contains subjectivity, deviation, interference, and cancellation characteristics, which will influence the primary theme report's communication effect, interfere with the audience's interpretation of the report, and cancel out the report's positive energy. The original intention of the theme report is to promote social harmony and safeguard social justice, but the appearance of negative information makes the reported effect fail to reach the expected purpose. The concept of theme reports and negative information is defined in this work. This study examines the primary topic report's qualities, such as The Times’ mainstream, good content, and strong report. In addition, the form and characteristics of negative information are also described. In this paper, a collaborative filtering recommendation method based on non-neighbor user contributions is suggested, which uses a linear fitting formula to apply the responsibilities of both neighbor and non-neighbor users to the recommendation system. The results show that the accuracy and diversity of our algorithm are better than those of traditional collaborative filtering algorithms. The diversity of several common recommendation algorithms is studied. The findings reveal that the diversity of recommendation algorithms is linked to the sparsity of data as well as the algorithm's suggestion mechanism. In general, the more scarce the data, the higher the recommendation algorithm’s variety. At the same time, we also study the diversity of recommendation systems, and the results show that although the overall diversity of the system is gradually decreasing, user behavior is becoming more and more diverse.
Gender Differences in Health Care Workers’ Risk-Benefit Trade-Offs for COVID-19 Vaccination
Authors: Presotto Maria Ada , Jörres Rudolf A. , Gesierich Wolfgang , Bullwinkel Jörn , Rabe Klaus F. , Schultz Konrad , Kaestner Franziska , Harzheim Dominik , Kreuter Michael , Herth Felix J. F. , Trudzinski Franziska Christina
Published: March 2022

Background: Gender differences in vaccine acceptance among health care workers (HCWs) are well documented, but the extent to which these depend on occupational group membership is less well studied. We aimed to determine vaccine acceptance and reasons of hesitancy among HCWs of respiratory clinics in Germany with respect to gender and occupational group membership. Methods: An online questionnaire for hospital staff of all professional groups was created to assess experiences with and attitudes towards COVID-19 and the available vaccines. Employees of five clinics were surveyed from 15 to 28 March 2021. Results: 962 employees (565 [72%] female) took part in the survey. Overall vaccination acceptance was 72.8%. Nurses and physicians showed greater willingness to be vaccinated than members of other professions (72.8%, 84.5%, 65.8%, respectively; p = 0.006). In multivariate analyses, worries about COVID-19 late effects (odds ratio (OR) 2.86; p < 0.001) and affiliation with physicians (OR 2.20; p = 0.025) were independently associated with the willingness for vaccination, whereas age <35 years (OR 0.61; p = 0.022) and worries about late effects of vaccination (OR 0.13; p < 0.001) predicted vaccination hesitancy; no differences were seen with respect to gender. In separate analyses for men and women, only for men worries about COVID-19 late effects were relevant, while among women, age <35 years, worries about late effects of vaccination and worries about COVID-19 late effects played a role. Conclusions: There was no overall difference in vaccination acceptance between male and female HCWs, but there were gender-specific differences in the individual reasons on which this decision-making was based.
Primary Extranodal Marginal Zone Lymphoma of the Renal Pelvis: A Case Report and Review of the Literature
Authors: Volkova Maria I. , Gridneva Yana V. , Probatova Natalia A. , Mochalnikova Valeria V. , Turupaev Kirill A. , Matveev Vsevolod B.
Published: March 2022

Lymphomas account for approximately 5% of nonurothelial tumors of the urinary tract and develop in the bladder in 90% of cases. The most common lymphomas histologic type of this location is extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). MALT lymphoma of the upper urinary tract is casuistically rare. The current study describes a case of a 74-year-old female patient with MALT lymphoma of the renal pelvis with metastases to the retroperitoneal lymph nodes who underwent radical surgical treatment with subsequent follow-up.
Effectiveness of Open Fenestration for Autosomal Dominant Polycystic Liver Disease
Authors: Norcia Luiz Fernando , Watanabe Erika Mayumi , Hasimoto Claudia Nishida , Pelafsky Leonardo , de Oliveira Walmar Kerche , Sassaki Ligia Yukie
Published: March 2022

Autosomal dominant polycystic liver disease (ADPLD) is a rare disease with variable clinical presentations, characterized by cystic enlargement of the liver. The diagnosis is made based on family history, patient’s age, and liver phenotype and is confirmed by imaging tests. The treatment aims to reduce symptoms caused by the increased liver volume and can be performed by aspiration with sclerotherapy, fenestration, and liver resection. Although ADPLD is a rare disease, it is an important differential diagnosis of cystic diseases such as polycystic kidney disease; therefore, the aim of this article was to present the diagnostic and therapeutic approach of a case of ADPLD and conducting a literature review. This is the case of a 32-year-old male patient, who was hospitalized due to abdominal pain, hepatomegaly, lack of appetite, and weight loss. Imaging propaedeutics showed a significant increase in the liver volume due to hepatic cysts. After a multidisciplinary evaluation, given the clinical changes and the location of the hepatic cysts, fenestration was performed by laparotomy. The postoperative period was uneventful. The treatment was efficient in promoting symptomatic relief and improving the quality of life in this patient. Case reports on this disease are quite limited in the currently available literature, and there are gaps in knowledge with regard to the diagnosis and management of ADPLD. The importance of this article is that it will highlight the limitations in treatment options and allow physicians to make a more informed decision when diagnosing and treating a patient with ADPLD in the future.
Small-Intestinal Metastasis from Lung Carcinoma
Authors: Ogasawara Naotaka , Ono Satoshi , Sugiyama Tomoya , Adachi Kazunori , Yamaguchi Yoshiharu , Izawa Shinya , Ebi Masahide , Funaki Yasushi , Sasaki Makoto , Kasugai Kunio
Published: March 2022

A 62-year-old man was referred to our hospital because of abdominal pain. Computed tomography revealed an approximately 7-cm-diameter tumor in the left abdomen with metastatic lymph nodes, an approximately 1-cm-diameter round tumor in contact with the subclavian artery in the apical lobe of the right lung, and mediastinal lymph node enlargement in contact with the superior vena cava. Esophagogastroduodenoscopy and colonoscopy revealed no abnormalities. Double-balloon endoscopy revealed a whole circumferential ulcer in the jejunum approximately 20 cm from the ligament of Treitz. Biopsy analysis of an ulcer specimen revealed a poorly differentiated carcinoma. Immunohistochemical staining of the specimen showed that it was positive for thyroid transcription factor 1 and cytokeratin 7 and negative for cytokeratin 20, GATA-binding protein 3, caudal-type homeobox protein 2, and paired box 8. Positron emission tomography revealed positive findings in the small-intestinal tumor, nearby mesenteric lymph nodes, lymph nodes around the abdominal aorta, lung tumor, and mediastinal lymph node in the apical lobe of the right lung. Accordingly, the patient was diagnosed as having a lung carcinoma with small-intestinal metastasis (T1b, N3, M1c; cStage IVB). Pathological examination helped distinguish the primary small-intestinal tumor from the metastatic small-intestinal tumor and detect the tumor origin.
Fitz-Hugh-Curtis Syndrome Presenting as Perihepatic and Subcapsular Enhancement on MRI
Authors: Kubo Kimitoshi , Ohara Masanori , Watanabe Ryosuke , Higashino Masayuki , Tsuda Momoko , Kato Mototsugu
Published: March 2022

Fitz-Hugh-Curtis syndrome (FHCS) is a rare complication of pelvic inflammatory disease and its MRI findings remain poorly described. A 34-year-old woman was raced to our hospital with slight fever and severe right upper quadrant pain. Gadoxetic acid-enhanced magnetic resonance imaging revealed high-intensity regions in the surface and subcapsule of the right liver on T2-weighted imaging and on diffusion-weighted imaging. A definitive diagnosis of FHCS was confirmed based on high titers of serum IgA and IgG antibodies to Chlamydia trachomatis. She was treated with oral azithromycin and discharged 6 days after admission with improvement of her symptoms. To our knowledge, this report represents a valuable addition to the FHCS literature describing MRI findings in the early stage of FHCS onset.
Semiotic Analysis of Beauty According to Roland's Barthes Theory in Relation to Indonesian and German Culture
Authors: Indira Dian , Susilo Catharina Dian Ikawati , Purnomowulan N. R.
Published: March 2022

A beauty has long been an interesting and important topic for women around the world. The concept of beauty cannot be generalized to all women in all parts of the world. Beauty for one community group is different from beauty for the other community groups because beauty is closely related to culture.   In the era of globalization, which is characterized by the ease of obtaining various information, the opportunity to learn about the beauty concepts of different countries is as wide open as possible. For this purpose, cosmetic advertisements in the mass media play an important role. However, there are signs in the advertisement that reflect cultural elements, which can be studied semiotically. This study uses a descriptive qualitative method. This paper is a semiotic study that aims to present the meaning of beauty myths for Indonesian and German women, which are first examined through denotative and connotative meanings. The theory used is the semiotic theory of Roland Barthes.  To see the difference in beautiful concepts from two different cultures, the data of Nivea skin care ads with Indonesian and German version are taken. In the results, there are differences of Indonesian and German beauty concept closely related to culture. The message of the beautiful Indonesian version shows that the woman is attractive and has a white skin, while the German version shows that the attractive level and skin color are not a priority, but women with the healthy skin.
Inhibitory Test of Bacillus sp. against Phytophthora palmivora Causes Cocoa Fruit Rot Disease
Authors: Anjarsari Devi Tria , Prasetyawati Endang Triwahyu , Wuryandari Yenny
Published: March 2022

Fruit rot is one of the important diseases in cocoa fruit, which is caused by Phytophthora palmivora. Farmers often control these pathogen using chemical pesticides. However, this method has a detrimental impact on the environment and health. More environmentally friendly fruit rot disease control can use biocontrol agency. Bacillus sp. is one of the biocontrol agents that is able to produce antibiotics that can inhibit the growth of pathogens, especially soil-borne pathogens and have the ability to colonize plant roots. The purpose of this study is to determine the potential of Bacillus sp. in inhibiting the growth of the pathogenic fungus Phytophthora palmivora in vitro. This study used two experimental factors, type of isolates Bacillus sp. Ba-6 isolate, Ba-9 isolate, Ba-12 isolate, Ba-15 isolate, and Ba-17 isolate and the concentration of Bacillus sp. (106 cfu/ml and 109 cfu/ml). The parameters observed were the inhibitory power and the mechanism of inhibition of Bacillus sp. against Phytophthora palmivora. The results of the best in vitro inhibition test on Ba12K2 treatment with an inhibition of 61% with an inhibitory mechanism, namely antibiosis, as evidenced by the presence of zones of inhibition and swelling of the hyphae.
Study on the Potential of Forest Areas in Aspects of Land Fertility In Wonosalam District, Jombang Regency
Authors: Maroeto Maroeto , Priyadarshini Rossyda , Siswanto Siswanto , Idhom Mohammad , Santoso Wahyu
Published: March 2022

Forests are one of the natural resources of high value for human benefit, both direct and indirect benefits. The management of forest resources does not date from the legal basis of Article 6 of Law no. 41 of 1999 (regarding Forestry) which states that natural resource management efforts in forest areas are carried out through protection, conservation and production functions by taking into account the continuity of their supply and the surrounding environment. UPN "Veteran" East Java as a State University in East Java proposes the Forest Area program with Special Purposes (KHDTK) as an effort to develop education and research as well as community service. The purpose of this research is to map forest areas based on fertility characteristics and land availability suitable for the development of KHDTK Wonosalam. The results of the research can be seen that 1. the forest area is based on the interrelation of land evaluation parameters on the distribution of forest land, the limiting factor for water availability in land use units 1, 2, and has primary obstacles in the dry season, resulting in drought and inappropriate land use. with its designation on land prone to erosion. Plants that dominate the forest area are annual plant species, including pine, clove and mahogany, while intercropping consists of coffee, banana and corn. Aspects of land fertility holistically have inhibiting factors, namely the low levels of elements C - Organic, available P and K2O. 2. Efforts to conserve land as an option for forest land management before the decline in land quality occurs by making irrigation and drainage channels to avoid water drought, applying organic fertilizers and selecting plants physiologically according to the characteristics of forest land. In addition, it is hoped that there will be an increase in water availability and land productivity by applying the principles of sustainable agriculture.
Effect of PGPR and Cow Manure on Growth and Yield of Purple Eggplant (Solanum melongena L.)
Authors: Saputri Andriana Ela , Djarwatiningsih Djarwatiningsih , Guniarti Guniarti
Published: March 2022

The less intensive cultivation of eggplant (Solanum melongena L.) and the occurrence of soil degradations are the causes of the decline in eggplant production. Therefore, more environmentally friendly effort are needed to increase eggplant production by using PGPR and cow manure. PGPR will work optimally when combined   with organic materials sourced from cow manure as nutrients trident for PGPR activity. The research was conducted from April to July 2021, in Plesungan village, Kapas District, Bojonegoro Regency, Jawa Timur. The research used a split plot design (RPT) with 16 treatment combinations and 3 replications. There are 48 trial plots. The sub plot was consentration PGPR (R) with 4 levels and dose of cow manure (K) as a main plot with 4 levesl. The data were analysed using the test of Duncan Multiple Range Test (DMRT) with a level of 5%. The result showed that there was an interaction between PGPR and cow manure. Treatment combination K3R3 (15 ton/ha cow manure + 30% NPK 15-15-15 dan 30 ml/l PGPR) increased the average plant height 17 day after planting by 2,80% and K3R2 (15 ton/ha cow manure + 30% NPK 15-15-15 dan 20 ml/l PGPR) increased the average total fruit weight of plant by 1,09%. PGPR was not significantly different in most of the parameters. Meanwhile, cow manure was significantly different in most of parameters.
Effect of ZnSO4 Fertilizer Application on Growth and Essential Oil Content of Green Betel Plant (Piper betle L.)
Authors: Suryawati Sinar , Laili Wahyu Nur , Murniyanto Eko
Published: March 2022

Green betel (Piper bettle L.) is a medical plant that contains essential oil and is widely used as one of the key ingredients of traditional herbal called jamu.  One of the particular micronutrients that play an important role in an enzyme activator is Zinc mineral (Zn). This research was aimed to discover the most effective doses of ZnSO4 fertilizer on growth parameters and essential oil production of green betel cultivated on red mediterranean soils in Bangkalan Madura, at ± 5 altitudes. This experiment was arranged as a single factor experiment in a completely randomized design with four replications. There were six levels of treatment namely Z0 (without ZnSO4), Z1(0,2 g/plant), Z2 (0.4 g/plant), Z3 (0.6/plant), Z4 (0.8 g/plant), Z5 (1 g/plant). Data collected from this experiment were analyzed using analysis of variance (ANOVA), followed by Duncan multiple ranged test (DMRT) ?? 5%. The results showed that the application of ZnSO4 fertilizer significantly affects vine height, number of leaves, number of branches, number of nodes, plant total dry weight, and essential oil content. Doses 0.6 g/plant of ZnSO4 was the best treatment compared to other doses applied in this research which increased the essential production of green betel up to 36.6% (1.405% w/w) compared to the control (without ZnSO4 application).
The Effect of Paitan (Tithonia diversifolia) dose on Growth and Yield of Potato (Solanum tuberosum L.) Granola Purple Flowered Variety
Authors: Dewanti F. Deru , Koentjoro Yonny , Sugiarto Sugiarto , Tarigan Puji Lestari
Published: March 2022

Potato farming in Jawa Timur currently tends to be oriented towards high production. Increasing the yield of potato quality is by controlling fertilizers and the population. The use of paitan as an organic fertilizer to replace an organic fertilizer is easy and efficient. This study aims to determine the effect of organic fertilizer application on the yield of Granola potatoes (Solanum tuberosum L.). Treatment using a dose of paitan (D) consisted of: D0 = Control (without fertilization), D1 = 120 kg N ha-1 equivalent to 5882 t ha-1 fresh paitan, D2 = 175 kg N ha-1 equivalent to 8,578 t ha-1 fresh paitan, D3 = 230 kg N ha-1 equivalent to 11,273 t ha-1 fresh paitan, D4 = 175 kg N ha-1 equivalent to Urea 380 kg ha-1, P2O 149.76 kg ha-1, K2O 100 kg ha-1. The treatment is given once a week before planting. Parameters observed were plant height and the number of tubers. The results of the study showed that paitan organic fertilizer equivalent to 380 kg N ha-1 was able to produce plant growth and yields that were no different when compared to inorganic fertilizers. In addition, the use of organic fertilizers can preserve the environment for long-term agricultural activities.
In Silico Analysis of Sox2 Gene for Pluripotency Detection at Mouse Embryonic Fibroblast and induced Pluripotent Stem Cell (iPSC)
Authors: Naroeni Aroem , Seprianto Seprianto , Moda Kevin Febrianus
Published: March 2022

Stem cells are cells that have not been specialized and have a specific characteristic compared to other cells. There are several transcription factors like Sox2, Oct4, c-Myc, and Nanog to maintain embryonic stem cells.  In pluripotent stem cells, sex-determining region Y-box 2 (Sox2) is a critical transcriptional regulator, and for somatic cell reprogramming, which involves returning differentiated cells to a pluripotent embryonic state by reversing their epigenetic arrangement. This study aimed to design primers for detecting the Sox2 gene expressed in Mouse Embryonic Fibroblasts and induced Pluripotency Stem Cell as pluripotency detection in stem cell research. In silico analysis was carried out to detect ofx2gene by using several software such as BLAST to search sequence Sox2 gene from Homo sapiens and Mus musculus, Bioedit for sequence alignment, SnapGene for PCR in silico, and PrimerBlast for online primer design. Primer candidates successfully designed were then analyzed for their secondary structure using NetPrimer. The results showed that forward primer (5'- CTACAGCATGTCCTACTCGCA -3') and reverse primer (5'- ACTTGACCACAGAGCCCA -3') were selected primers for M. musculus. Also, forward primer (5’-CTACAGCATGTCCTACTCGCA-3') and reverse primer (5'- ACTT-GACCACCGAACCCA-3') for Homo sapiens. Detection by PCR in silico using templates from H. sapiens and M. musculus sequences showed that the primers could specifically amplify the Sox2 gene in each species. Nevertheless, laboratory experiments need to be carried out for preliminary validation that has been designed. These primers will be used to measure the gene expression of Sox2 in qRT-PCR to detect the stemness characteristic of stem cells.
Analysis of Self-Medication Patterns in South Surabaya Community in the Era of the COVID-19 Pandemic
Authors: Sari Wening , Nabilah Della Nanda Shafa
Published: March 2022

Background: Indonesia implemented a large-scale social restriction policy throughout the COVID-19 pandemic. Hospitals and alternative health care facilities are places with a high risk of COVID-19 transmission. The general public is suggested to limit visits to health facilities unless it is an emergency. Supported this, we hypothesize that people prefer to self-medicate to take care of relatively mild health complaints at home. This study aims to analyze the pattern of self-medication within the community in the era of the COVID-19 pandemic. Methods: A cross-sectional survey was conducted on 110 residents of South Surabaya with a structured questionnaire during the COVID-19 outbreak in December 2021, to observe patterns and factors that influence people's decisions to take self-medication before and during the COVID-19 pandemic era. Results: As several as 40% of respondents had self-medication before the COVID-19 pandemic, while the prevalence of self-medication within the thick of the COVID-19 outbreak was 57.3%. The most reasons for self-medication are the concern of reaching the hospital will be being exposed to COVID-19 (67.3%), the sickness is not severe enough, compatible with the previous medication, and more efficient. The community's advantages of self-medication are that it is faster to treat (41%) and cheaper (21.8%). Conclusions: The study revealed that there was an increase in the number of respondents who did self-medication during the COVID-19 pandemic with the main reason being fear of going to the public health center or hospital.
Improving Student Outcomes Using Cognitive Load Theory-Based Multiple-Assessments throughout Online Learning of the Musculoskeletal Block During the COVID-19 Pandemic
Authors: Nurhadi Asty Amalia , Salmah Shelly , Soraya Gita Vita , Ardiansyah Bau Dilam , Rafiah Sitti
Published: March 2022

Since its first emergence in China, the global spread of COVID-19 had reached 269.721.683 cases in over 200 countries in December 2021. The rapid spread of this virus had urged WHO and governments to establish policies on physical distancing. Restriction of offline learning activities in Indonesia forced the educational institution to rapidly adapt. As consequence, we had to change all learning and assessment processes into online forms. We found many challenges in the implementation, particularly in the assessment processes. Therefore, in consideration of Cognitive Load Theory, we decided to intervene in these problems by implementing multiple assessment strategies in Musculoskeletal System Course, for 2020 batch students. We compared the results of the 2020 cohort with the results of the 2019 cohort in the Musculoskeletal System using the Mann-Whitney test (SPSS version 24). There were 256 students (2020 cohort) who participated in this System in comparison to 318 students (2019 cohort). Statistical analysis showed that there was a significant difference between the outcomes of the 2020 cohort that experienced multiple assessments before final examination in comparison to 2019 cohort who only experienced single-end examination (p value <0.000). Mean outcomes of 2020 cohort (334.34) where significantly higher compared to 2019 cohort (240.96). Our study had shown that students’ outcome during online learning due to COVID-19 pandemic can be improved by chunking the volume of learning materials into several parts. This method was in line with Cognitive Load Theory and gave possibility for students to organize their learning as well as to get multiple feedback for their improvement.
Electrocardiographic Findings, Arrhythmias, and Left Ventricular Involvement in Familial ST-Depression Syndrome
Authors: Christensen Alex Hørby , Vissing Christoffer Rasmus , Pietersen Adrian , Tfelt-Hansen Jacob , Hartvig Lindkær Jensen Thomas , Pehrson Steen , Henriksen Finn Lund , Sandgaard Niels Christian Foldager , Iversen Kasper Karmark , Jensen Henrik Kjærulf , Olesen Morten Salling , Bundgaard Henning
Published: March 2022

Background:

Familial ST-depression syndrome is an inherited disease characterized by persistent, nonischemic ST-deviations, and risk of arrhythmias and heart failure. We aimed at further characterizing the ECG, arrhythmias, and structural characteristics associated with this novel syndrome.

Methods:

Retrospective analysis of data from consecutive families with familial ST-depression Syndrome in Denmark. ECG features, prevalence and type of arrhythmias, occurrence of systolic dysfunction, and medium-term outcome were analyzed.

Results:

Forty affected individuals (43% men; mean age at diagnosis 49.1 years) from 14 apparently unrelated families with ≥2 affected members were included. Autosomal dominant inheritance was observed in all families. The ECG phenotype seemed to develop in prepuberty and the ST-deviations were persistent and most pronounced in leads V4/V5/II, respectively. Serial ECG analyses showed stable to slow progression of the ECG phenotype. Exercise accentuated the ST-deviations with a maximum difference between rest/stress (mean) of −117 μV in lead V5. During a mean follow-up of 9.3±7.1 years 5 (13%) patients developed sustained ventricular arrhythmias or (aborted) sudden cardiac death, 10 (25%) developed atrial fibrillation, 2 (5%) other supraventricular arrhythmias, and 10 (25%) were diagnosed with left ventricular ejection fraction ≤50%. The ventricular arrhythmias were polymorphic with relatively short-coupled premature ventricular contractions at onset (300–360 ms); no QT prolongation was observed. Seven patients had at least one catheter ablation; 5 for supraventricular arrhythmias and 2 for ventricular arrhythmias. Males experienced more arrhythmic end points than females (
P
<0.01).

Conclusions:

The familial ST-depression ECG phenotype is stable to slowly progressive after medium-term follow-up. Clinically, both supra- and ventricular arrhythmias are common; as are some degree of left ventricular systolic dysfunction. Familial ST-depression represent a novel inherited cause of polymorphic ventricular tachycardia.
Cari İşlemler Dengesi ile Ekonomik Büyüme Arasındaki İlişki: Türkiye Örneği
Authors: BOLKOL Hakkı Kutay , TÜRKÖNDER Fatih
Published: March 2022

Bu çalışmanın temel amacı, 2003-2019 dönemine ait çeyreklik verileri kullanarak Türkiye'de cari işlemler dengesi ile ekonomik büyüme arasındaki ilişkiyi incelemektir. Çalışmada ARDL yaklaşımı uygulanmıştır. Cari işlemler dengesi Türk Lirasına dönüştürülmüş ve daha sonra TÜFE kullanılarak enflasyon etkisinden arındırılmıştır. Elde edilen sonuçlar, reel GSYH büyümesi ile hem kısa hem de uzun vadede cari işlemler dengesi arasında anlamlı, karşılıklı negatif yönlü bir ilişki olduğuna dair güçlü kanıtlar sunmaktadır. Kısacası bir değişkendeki pozitif yönlü değişim, diğer değişkene negatif yönde bir etki yapmaktadır. Açmazdan çıkış için ileri teknoloji ve katma değer üretecek, beraberinde yan sanayiyi peşinden sürükleyecek odak sektörler kamu finansmanı ve hatta sermayesi ile desteklenmelidir.
The Mitigating Role of Renewable Energy Sources on the Welfare Cost of Air Pollution in APEC Countries
Authors: ÇETİN Mümin Atalay , BAKIRTAŞ İbrahim
Published: March 2022

The main purpose of this study is to determine the possible long run impacts of renewable energy supply on the welfare cost of premature deaths caused by air pollution in the Asia-Pacific Economic Cooperation (APEC) countries during 1990-2016 by using dynamic panel data techniques. The long run elasticity results showed that the increasing supply of renewable energy sources reduces the welfare cost of air pollution. Empirical findings revealed that clean energy should not just seen as a sustainable energy source but also considered as an efficient way to struggle with possible negative externalities of pollution.
Genç Tüketicilerin Elektronik Ödeme Yöntemi Kullanımlarının Belirleyicilerine Dair Alan Araştırması
Authors: TOMBAŞ Helin , ÇELİK Asiye Ayben
Published: March 2022

Tüketim pratiklerinin çevrimiçi platformlara artan bir ivmeyle kayıyor olması, beraberinde işletmelerin bu platformlardan yapılan alışverişlerde tüketicilerin olumlu bir deneyimle ayrılması hedefine odaklanmasına neden olmaktadır. Tüketiciye sunulan hizmetin tasarımında satın almanın kilit noktası olan ödeme süreçlerinin doğru şekilde yönetimi önemlidir. Bu bağlamda tüketiciye sunulan elektronik ödeme yöntemlerine dair tüketicinin duyduğu güven ve güvenlik algısı alışverişin satın almayla noktalanmasında belirleyici olacaktır. Çalışmada e-ödeme yöntemlerinin özelliklerinin, algılanan güven ve güvenlikle ilişkisinin sorgulandığı, ayrıca algılanan güven ve güvenliğin elektronik ödeme yöntemlerinin kullanımıyla ilişkisinin incelendiği kavramsal bir model ortaya konulmaktadır. 503 üniversite öğrencisinden anketle toplanan veri, yapısal eşitlik modellemesiyle analiz edilmiştir. Elde edilen bulgular, ödeme yöntemlerine dair güvenlik bildirimleri ve işlem prosedürlerinin algılanan güven ve güvenlik ile pozitif bir ilişkiye sahip olduğu ve algılanan güven ve güvenliğin elektronik ödeme yöntemlerinin kullanımında belirleyicisi olduğu sonucunu göstermektedir.
Avrupa Birliği’nin Kolektif Sektörel Çarpanları
Authors: TOPCUOĞLU Abdullah , ERGİN Emre
Published: March 2022

Bu çalışmada Avrupa Birliği yekpare bir devlet olsaydı, hangi sektörlerin Üretim, İstihdam ve Gelir Çarpanları öne çıkardı sorusuna cevap aranmaktadır. Bu bağlamda tüm AB ülkelerinin en güncel verilerine sahip olduğu için World Input Output Database (WIOD; Timmer vd., 2015:575)’de yer alan 2014 yılı Girdi-Çıktı tabloları kullanılmıştır. Çalışma kapsamında AB’yi tek bir ülke halinde inceleyebilmek adına AB ülkelerinin her birine ait olan girdi-çıktı tabloları toplulaştırılmıştır. Toplulaştırma sonucunda elde edilen kümülatif girdi-çıktı tablosu ve 28 ülkenin her birine ait olan girdi-çıktı tabloları yani 29 girdi-çıktı tablosu tek tek analiz edilmiş ve bulunan sonuçlar birbiriyle karşılaştırılmıştır. Böylelikle üye ülkeler ile kolektif AB ekonomisi arasındaki farklı ve benzer yönler, çarpan analizine göre belirlenmiştir.
Falling into Vínland
Authors: Kristjánsson Jónas , Einarsson Bjarni F. , Jónasson Kristján , McAleese Kevin , Hjaltalín Þór
Published: March 2022

Two interwoven topics are dealt with, firstly a new interpretation of the Icelandic Sagas and historical written sources on the Viking age voyages to North America, leading to a theory on the location of Vínland, and secondly an archaeological survey of deer hunting pitfalls in Newfoundland, which were possibly dug by the Nordic voyagers a millenium ago. According the theory of the article, Vínland is the modern day Newfoundland, and the Straumfjord of the sagas, where Thorfi nn Karlsefni and Gudríd Thorbjarnardóttir attempted settlement could be Sop’s Arm in White Bay on the North coast of Newfoundland. The system of pitfalls that was surveyed and excavated is close to Sop’s Arm. The pitfalls form an 82 metre long system that lies in an almost straight line. Individual pits are now 1.5–2.3 metres deep and 7–10 metres long. Two pitfalls were excavated by taking a section into them. Attempted radiocarbon dating of soil from two pitfalls was inconclusive. Considerable soil thickening of 55–110 centimetres since the pitfall construction was observed.
Medieval Logic Diagrams
Authors: O’Meadhra Uaininn
Published: March 2022

This article describes the finding, documentation and significance of the set of medieval logic diagrams and associated text, all in highly abbreviated Latin minuscule, sketched on an inside wall of the Romanesque tower of the parish church in Bro, near Visby. The diagrams depict the Square of Opposition, the basic concept to be mastered in introductory logic as taught at medieval schools and universities. A date c.1200-1225 is suggested by their being executed in the earliest plaster when wet (tower built c.1200), while up to 1350 is suggested by palaeography. Dating by textual content is still in progress. Either way the Bro diagrams are among the earliest logic texts written in Scandinavia, and this is the first time for such texts to be found outside a manuscript. They are also the earliest known physical evidence of a teaching session or a discourse in logic. Furthermore they contribute to a growing body of evidence of the high standard of learning that existed in medieval Gotland.
The Earliest Neolithic at Vedbæk Fjord, Denmark
Authors: Juel Christian , Kjær Anders
Published: March 2022

The investigation of a stratigraphically isolated settlement layer from the Earliest Neolithic (3950 – 3640 cal BC) at the Maglemosegård site, Northeast Zealand, reveals the nature of the Earliest Funnel Beaker horizon by the Stone Age Vedbæk Fjord. The settlement layer at Maglemosegård consists of small concentrations of fi nds, where only the presence of Funnel Beaker ceramics is typologically datable to the Neolithic. This is also the case on other Funnel Beaker sites in the area, where the Neolithic element is diffi cult to recognize from the lithic material and among the faunal remains. This problem of visibility is also relevant in a larger geographical perspective, especially where Early Neolithic and Mesolithic material are present at the same site. The lesson from Vedbæk and elsewhere too, suggests that the character and speed of the Mesolithic-Neolithic transition has to be revised.
Insular Crosiers from Viking-Age Scandinavia
Authors: Murray Griffin
Published: March 2022

This is the fi rst detailed study of a group of fi ve Insular crosier fragments from Viking-age Scandinavia. The European importance of this material, which includes some of the earliest extant crosiers in Western Europe, the earliest extant volute-headed crosier, and the earliest evidence for crosier use in England, is discussed and it is argued that the Insular and Continental crosier traditions were closer to each other than has previously been recognised. In recent years this material, as well as other fragmented Insular Church metalwork from the Nordic countries, has been used to support the notion of early undocumented Christian missions to Scandinavia. This theory is challenged in this paper, which concludes that it is far more likely that this material arrived in Scandinavia as a result of Viking raids on the church sites of Ireland and Britain.
A new species of Galene de Haan, 1833 (Galenidae: Brachyura) from the middle Miocene of Zagros Mountains, Iran
Authors: KHOSRAVI ERFAN , SARI ALIREZA , MIRZIEE-ATAABADI MAJID , GHOLAMALIAN HOSSEIN , HYŽNÝ MATÚŠ , NADERLOO REZA
Published: March 2022

A new species of Galene de Haan, 1833 (Decapoda: Brachyura: Galenidae) is described from the Mid Miocene (Langhian) strata of the Mishan Formation exposed at two localities in Hormozgan Province, Zagros Mountains, Iran. The galenid species, Galene dashtbani n. sp. is considered as the oldest representative of the genus and simultaneously the westernmost occurrence of all fossil and extant congeners known to date. The genus is currently limited to the Indo-West Pacific region. The present fossil occurrence of the genus suggests a Tethyan origin and subsequent migration eastward.
Analytical Study on Magnetohydrodynamic Nanofluid Flow Influenced by Electrical Conductivity in a Baffled Vertical Channel
Authors: Karuna Prasad M. , Raghu Vamshi Krishna B. V. , Raju C. S. K. , Chamkha Ali J.
Published: March 2022

The theoretical analysis of the steady fully developed electrically conducting flow of water based nanofluid in a vertical double passage channel is studied. The governing equations are respectively solved analytically and semi-analytically for each flow using perturbation method and
the differential transformation method (DTM). The effects of flow governing parameters on the flow and velocity fields are numerically evaluated and presented in the graphical form. The outcome obtained by semi analytical method is confirmed by comparing with the aid of perturbation method
and good agreement is found.
Effect of Advection by Upper-Tropospheric Background Zonal Wind on MJO Phase Speed
Authors: Roundy Paul E.
Published: March 2022

A robust linear regression algorithm is applied to estimate 95% confidence intervals on the background wind associated with Madden–Julian oscillation (MJO) upper-tropospheric atmospheric circulation signals characterized by different phase speeds. Data reconstructed from the ERA5 to represent advection by the upper-tropospheric background flow and MJO-associated zonal wind anomalies, together with satellite outgoing longwave radiation anomalies, all in the equatorial plane, are regressed against advection data filtered for zonal wavenumber 2 and phase speeds of 3, 4, 5, and 7 m s−1. The regressed advection by the background flow is then divided by the negative of the zonal gradient of regressed zonal wind across the central Indian Ocean base longitude at 80°E to estimate the associated background wind that leads to the given advection. The median estimates of background wind associated with these phase speeds are 13.4, 11.2, 10.5, and 10.3 m s−1 easterly. The differences between estimated values at neighboring speeds suggests that advection acts most strongly in slow MJO events, indicating that the slowest events happen to be slow because they experience stronger easterly advection by the upper-tropospheric background wind.

Significance Statement

The Madden–Julian oscillation (MJO) is the dominant subseasonal rainfall signal of the tropical atmosphere. This project shows that the background wind of the tropical atmosphere most especially slows down the slowest MJO events. Understanding what controls its speed might help scientists better predict events.
Temperature-Dependent Infrared Refractive Index of Polymers from a Calibrated Attenuated Total Reflection Infrared Measurement
Authors: Azam Md S. , Ranson Malcolm D. , Hore Dennis K.
Published: March 2022

We demonstrate a straightforward method by which a commonly available reference sample such as water can be used to calibrate an attenuated total internal reflection infrared absorbance measurement in order to account for the polarization of the beam incident on the internal reflecting element, and the spread of angles about the nominal angle of incidence. This enables quantitative comparison of attenuated total reflection-derived absorbance data with spectra calculated from optical constants. We then apply this calibration to the measurement of temperature-dependent absorption spectra of a polydimethylsiloxane sample. We illustrate that the extracted optical constants scale with the temperature-dependent changes in the polymer density better than the raw absorbance values on vibrational resonance.
George Engel: A Personal Reminiscence
Authors: Singh Bruce S.
Published: March 2022

Objective

To provide a review of my personal exposure to the Medical Psychiatric (Medical Psy) Liaison Group in Rochester during the tenure of a National Health of Medical Reseach Council Travelling Fellowship in the Clinical Sciences from June 1975 to March 1977.

Method

A personal reminiscence and review of a number of papers by George Engel.

Results

The Medical Psy Liaison Group had been developed by George Engel in 1946. My experiences were coloured by the fact that Engel had recently stepped down as Head and tensions in the structure and function of the group were obvious.

Conclusion

My personal experience with Engel, the Medical Psy Liaison Group, Rochester psychiatry and my exposure to American psychiatry all had major influences on my subsequent career but perhaps not in a way that I might have expected when I went to Rochester.
Can the Periphery Speak: The Self-Representation of Tokugawa Japan’s Periphery in Suzuki Bokushi’s Hokuetsu Seppu
Authors: Sheikh Tariq
Published: March 2022

Suzuki Bokushi (1770–1842) was a peasant-entrepreneur, essayist and amateur haikai poet who lived in the Echigo province of Tokugawa period Japan, a region which gets the highest amount of snowfall in the world. Bokushi wrote about the people of his region, their customs, their lifestyle, their relationship with the natural world and the folklores of the region in a book entitled Hokuetsu Seppu (1837). This essay will examine the ways this book interrogated the dominant cultural discourse and offered new ways of thinking about centre and periphery, urban and rural. An analysis of the text and context of the book will show how ‘provinciality’ was deployed to question and de-centre prevailing cultural norms, and how a new aesthetic sense was developed that contrasted and questioned the urban sensibilities prevailing in the political centre. This essay will argue that Bokushi’s book articulates a significant critique of the urban-centric discourse of classical Japanese literature, while also offering an alternative rural aesthetic, thereby countering the hegemonic tendency to read the Japanese past through the lens of urban-centric literature. His writings are what Fredric Jameson would call a ‘nonhegemonic cultural voice’.