bluuebunny/crossref_metadata_2025 huggingface dataset:
FEN1 Status and Its Correlation with Clinicopathologic Characteristic in
Colorectal Cancer
Authors: Guo Yundi , Du Zixuan , Zhou Yuanshuai , Sun Haijun , Liang Rui , Sun Min-Xuan , Tang Zaixiang , Liu Song-Bai
Published: April 2021

Objective::

The goal of this study was to investigate the status of FEN1 in colorectal
cancer (CRC) and determine the potential correlation between FEN1 expression level and
clinicopathological parameters in CRC patients.

Methods::

Expression of FEN1 in CRC tissue on tissue microarray was detected using
immunohistochemistry (IHC). The relationship between FEN1 expression status and
clinicopathologic characteristics of CRC was analyzed by the Chi-square test. The survival data of
TCGA Colon Cancer (COAD) were obtained from ucsc xena browser (https://xenabrowser.net/).
Patients were separated into higher and lower expression groups by median FEN1 expression. The
association with prognosis of CRC patients was determined by Kaplan-Meier survival analysis
with Log-rank test.

Results::

FEN1expression level and cellular localization had wide variability among different
individuals; we classified the staining results into four types: both positive in nucleus and
cytoplasm, both negative in nucleus and cytoplasm, only positive in the nucleus, only positive in
the cytoplasm. Moreover, FEN1 expression status only correlated with patient’s metastasis status,
and the patients in the NLCL group showed more risk of cancer cell metastasis.

Conclusion::

Our results indicate that FEN1 expression level and cellular localization had wide
variability in CRC and is not a promising biomarker in CRC.
A Brief Review of circRNA Biogenesis, Detection, and Function
Authors: Liang Ying , Liu Niannian , Yang Le , Tang Jianjun , Wang Yinglong , Mei Meng
Published: April 2021

:

Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing
of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC).
Its formation depends on complementary intron sequences on both sides of the circularized sequence.
CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator
or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain.
In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We
also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA
prediction. Finally, we discuss the state of the research on circRNA in diseases, which will
bring new contributions to future disease treatments.
Cytotoxic and Apoptotic Effect of Iris taochia Plant Extracts on Human
Breast Cancer (MCF-7) Cells
Authors: Yazgan Burak , Ozcelik Ozlem , Ayar Arif , Renda Gülin , Yıldırım Tuba
Published: April 2021

Introduction:

Iris taochia is an endemic plant in Turkey. Iris species has many biological
effects such as antibacterial, antiinflammatory, antioxidant and anticancer properties. Apoptosis
is a programmed cell death and this mechanism regulates the death of cancer cells.

Purpose:

The aim of our work is to investigate how the Iris taochia extracts affect the apoptotic activity
in the MCF7 cells.

Methods:

Cytotoxic dose and cell viability is determined by the MTT assay. Bad, Bax, Bcl-2, Bcl-
W, Bid, Bim, Caspase 3, Caspase 8, CD40, CD40L, cIAP-2, CytoC, DR6, Fas, FasL, HSP27,
HSP60, HSP70, HTRA, IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5,
IGFBP-6, IGF-1sR, Livin, p21, p27, p53, SMAC, Survivin, sTNF-R1, sTNF-R2, TNF-α, TNF-β,
TRAILR-1, TRAILR-2, TRAILR-3, TRAILR-4 and XIAP proteins were measured by the membrane
array kit.

Results:

Iris taochia extracts exhibited significant cytotoxic effects on MCF7 cells and IC50 values
ranging from 1.56 to 100 μg/mL. Our results indicate that MeOH extract of Iris taochia in MCF7
cells may be a regulator of cell death proteins, cell cycle and growth factors. DCM and EtOH extracts
of Iris taochia have a limited effect on MCF7 cells, especially, HSPs, which play a significant
role in chemoresistance, downregulating DCM and EtOH extracts of Iris taochia, whereas ligands
and receptors of extrinsic apoptotic pathway are upregulated by these extracts.

Conclusion:

This is the first study to investigate the cytotoxic and apoptotic effect of Iris taochia
extracts on MCF7 cells. Results also showed that Iris taochia reduced cell viability and induced
apoptotic pathways as a potential regulator of cancer cell death.
Elucidating the Dynamics and Selective Mechanistic Mode of Inhibition of
a Novel Poly ADP-Ribose Polymerase-1 Inhibitor
Authors: Okunlola Felix O. , Soremekun Opeyemi S. , Olotu Fisayo A. , Soliman Mahmoud E.S.
Published: April 2021

:

Poly ADP-ribose polymerase-1 (PARP-1), due to its role in DNA damage and repair, has
been identified as a crucial therapeutic target to attenuate cancer development and progression.
More so, selective inhibition has remained a focal point in PARP-1 targeting and has led to the development
of numerous compounds, including the recently identified Cpd10n, a novel homoerythrina
alkaloid derivative. To expound on the selective PARP-1 inhibition mechanisms by
Cpd10n, we employed computational simulation methods in this study. Findings revealed that the
inhibitor stabilized the characteristic motion of activated PARP-1 as evidenced by reductions in
residual deviations and structural flexibility. Findings further revealed that Cpd10n was favorably
bound at the active site PARP-1 as supported by the occurrence of strong hydrogen and halogen
bonds based on complementarity. These were in addition to aromatic bonds with an enhanced ring
to ring stability. Steady and high-affinity interactions between the fluorine atom of Cpd10n and
Glu988 could potentiate the selective activity of the compound. Interaction analyses also revealed
that inhibitor binding was strongly dependent on electrostatic effects over van der Waal contributions,
which were relatively minimal. We believe findings from this study will further contribute to
the rational structure-based design of highly selective PARP-1 inhibitors.
Synthesis, Characterization, Molecular Docking, In Vitro Biological Evaluation and In Vitro Cytotoxicity Study of Novel Thiazolidine-4-One Derivatives as Anti-Breast Cancer Agents
Authors: Kadhim Zainab Y. , Alqaraghuli Hasanain G.J. , Abd Muna Tawfeeq
Published: April 2021

Background:

Thiazolidine-4-one is a promising class of heterocyclic compounds with interesting
pharmacological and biological activities, such as anticancer and antibacterial. Therefore, many researchers have
synthesized thiazolidine-4-ones and evaluated their biological potential for developing new drugs.

Objective:

In this study, two novel thiazolidine-4-one derivatives (T1 and T2) were synthesized and evaluated
for their antibacterial activity toward Staphylococcus aureus, Escherichia coli, and Proteus mirabilis. Also, the
cytotoxic activities of compounds T1 and T2 were estimated against MCF-7 (HER2+, ER+, and ER+) and MDAMB-
231 (triple-negative) human breast cancer cell lines. The chemical structures of the compounds T1 and T2
were proven using spectral techniques (FT-IR, 1HNMR, and 13CNMR) and CHN elemental analysis.

Methods:

The synthesis of thiazolidine-4-one compounds was performed in two steps. The first step consisted of
the formation of Schiff bases S1 and S2. In the second step, the synthesized Schiff bases were reacted with
thioglycolic acid to prepare thiazolidine-4-one compounds. Hemolysis assay, molecular docking, cytotoxicity
activity (MTT assay), and antibacterial activity (disc diffusion assay) were studied.

Results:

The hemolysis study demonstrated that the hemolytic ratio of compounds T1 and T2 at (1, 2, and 3)
mg/ml was less than 4%. MTT assay showed that 100 μg/ml of compounds T1 and T2 diminish the MCF-7 cell
growth up to 80.05 ± 1.72 and 69.85 ± 3.26 respectively after 72hr., while the same concentration of compounds
T1 and T2 reduces the MDA-MB-231 cell growth up 70.28 ± 2.31 and 57.15 ± 1.49, respectively. The inhibition
zones of T1 and T2 were 12 mm at 50 mg/ml and 10 mm at 5 mg/ml in E. coli bacteria. Furthermore, a docking
study was carried out to investigate the affinity and binding mode of compounds T1 and T2 towards the ERα,
VEGF, and HER2 protein receptors in breast cancer cells. Data obtained from the docking study were exactly
identical to that obtained from in vitro cytotoxicity assay.

Conclusion:

The results proved that T1 is an optimal anticancer agent toward breast cancer cells and the
hemolysis study indicates the use of safety inside the body for compound T1. Synthesized compound T1 was
most effective against MCF-7 cells compared to MDA-MB-231 cells and more effective than the reference drug
tamoxifen in breast cell lines. The high cytotoxicity of T1 on the growth of MCF‐7 cells because T1 binds with a
high degree of affinity to the estrogen and HER2 receptors, which in turn inhibits cell proliferation and induces
apoptosis.
Zebrafish Avatar to Develop Precision Breast Cancer Therapies
Authors: Corsinovi Debora , Usai Alice , Sarlo Miriam De , Giannaccini Martina , Ori Michela
Published: April 2021

Background:

Zebrafish (Danio rerio) is a vertebrate that has become a popular alternative model for
the cellular and molecular study of human tumors and for drug testing and validating approaches. Notably,
zebrafish embryos, thanks to their accessibility, allow rapid collection of in vivo results prodromal to validation
in the murine models in respect to the 3R principles. The generation of tumor xenograft in zebrafish embryos and
larvae, or zebrafish avatar, represents a unique opportunity to study tumor growth, angiogenesis, cell invasion
and metastatic dissemination, interaction between tumor and host in vivo avoiding immunogenic rejection,
representing a promising platform for the translational research and personalized therapies.

Objective:

In this mini-review, we report recent advances in breast cancer research and drug testing that took
advantage of the zebrafish xenograft model using both breast cancer cell lines and patient’s biopsy.

Conclusion:

Patient derived xenograft, together with the gene editing, the omics biotechnology, the in vivo time
lapse imaging and the high-throughput screening that are already set up and largely used in zebrafish, could
represent a step forward towards precision and personalized medicine in the breast cancer research field.
Impact of Right Ventricular Function on Left Ventricular Torsion and Ventricular Deformations in Pulmonary Artery Hypertension Patients
Authors: Nayak Krishnananda , Razak Abdul , Megha A. , Padmakumar R. , Samantha Jyothi , Varghese Sara
Published: April 2021

Introduction:

Ventricular interdependence in pulmonary arterial hypertension (PAH) by
the use of most recent echocardiographic techniques is still rare. The current case-controlled study
aims to assess left ventricular (LV) torsion in patients with PAH.

Methods:

The study included 42 cases of moderate to severe PAH and 42 age and gender-matched
healthy controls between March 2016 and January 2018. All the patients and controls undergo routine
practice echocardiography using the Vivid 7-echocardiography (2.5MHz transducer) system.

Results:

The LV twisting parameters, peak basal rotation, peak apical rotation, and twist were similar
among both cases and controls, however, LV torsion was significantly (p=0.04) impacted. Right
ventricular (RV) longitudinal deformation was clinically significant in the cases compared to controls:
RV systolic strain imaging (p=0.001, 95% CI-9.75 to -2.65), RV systolic strain rate (p=0.01,
95% CI-0.99 to -0.09), and RV late diastolic strain rate (p=0.01, 95% CI-0.64 to -0.85). Although
PAH did not impact longitudinal LV deformations significantly. At basal level circumferential
strain and strain rate were significantly impacted (p=0.005, 95% CI-4.38 to -0.70; p=0.004, 95%
CI-0.35 to -0.07) in the PAH group, while the radial strain was preserved. All RV echocardiographic
parameters and LV end-diastolic dimension, LV end-systolic volume in the PAH were affected
significantly (p=0.002, 95% CI-19.91 to -4.46; p=0.01, 95% CI-8.44 to -2.77). However, only a
weak correlation (p=0.05, r =-0.20) was found between tricuspid annular plane systolic excursion
and LV Tei index.

Conclusion:

RV pressure overload directly affects RV longitudinal systolic deformation further influences
the interventricular septal and LV geometry, which impaired LV torsion.
Photocatalytic Heavy Metal Detoxification from Water Systems
Authors: Kumar P.S.
Published: April 2021

Heavy metals are one of the greatest elevating threat to mankind and other living organisms and it is released into the environment due to increasing dumpsites, transports, and industrial sectors. The industrial wastewater containing heavy metal ions easily enters into the food chain through the air, water, and soil; it results in bioaccumulation and biomagnifications of metal ions in human beings. It causes severe chronic health disorders affecting the nervous system, circulatory system, digestive system and other sensitive organs of the human body. Many conventional techniques such as adsorption, coagulation, flocculation, electrochemical treatment, and biological treatment are used for the reduction of heavy metal ions in the aqueous system. The photocatalysis method is one of the emerging effective ways for eliminating the toxic metal ions from the aqueous solution. This chapter elaborates the principle, mechanism and various methods utilized in the photocatalytic reduction of heavy metal ions from the wastewater.
Carbon Nanotubes based Nanocomposites as Photocatalysts in Water Treatment
Authors: Tan T.L.
Published: April 2021

The shortage of worldwide clean water and the increasing water demand are now ubiquitous problems around the world. Thus, efficient water treatment is an important research topic, of which phocatalysis is known as simplest and efficient technique utilized in the photocatalytic degradation of all major water pollutants, including heavy metal ion, organic and inorganic pollutants. In this context, the use of one- dimensional carbon nanotubes-based nanocomposites in water treatment have been widely demonstrated to be capable of removing persistent organic compounds due to their unique physical and electronic properties, large surface area, tunable morphology, biocompatible and chemical-environmental-thermal stability. This chapter begins with the discussion of the importance and properties of carbon nanotubes, and then briefs about the types and methods of preparation of carbon nanotubes-based nanocomposites in detail. The next section emphasizes the fundamentals of photocatalysis phenomenon and its proposed mechanism for the photocatalytic degradation of pollutants. The last section highlights the recent development in the carbon-based nanocomposites as photocatalyst in water treatment systems, supported by comprehensive literature account. Finally, the remaining challenges and perspectives for using carbon nanotubes-based nanocomposites are discussed.
Recent advances in Photocatalytic Nitrogen Fixation
Authors: Saravanan A.
Published: April 2021

Nitrogen fixation is a standout amongst the most significant concoction responses in the biological system of our planet. Under the regularly pressure of the petroleum product exhaustion emergency and anthropogenic worldwide environmental change with ceaseless CO2 emanation in the 21st century, examine focusing on the union of NH3 under gentle conditions in an economical and condition agreeable way is lively and flourishing. Thusly, the focal point of this survey is the cutting edge designing of effective photocatalysts for dinitrogen (N2) obsession toward NH3 amalgamation. Creating green and feasible techniques for NH3 combination under surrounding conditions, utilizing sustainable power source, is firmly wanted, by both modern and logical scientists. Photosynthesis for ammonia synthesis, which has as of late pulled in noteworthy consideration, straightforwardly creates NH3 from daylight, and N2 and H2O by means of photocatalysis. Photocatalysts containing copious surface oxygen-opportunities and coordinative unsaturated metal locales have been demonstrated to be equipped for actuating N2 reduction under fitting photoexcitation. A few impetus materials are examined which incorporate metal oxides, metals sulfides, carbon-based impetuses, and metal nitrides which are for the most part right now being sought after for their better use of their synergist property towards nitrogen fixation. This chapter portrays the photocatalytic reduction systems of nitrate towards unwanted items (nitrite, ammonium) and the more alluring item (dinitrogen).
Perovskites based Nano Heterojunctions for Photocatalytic Pollutant Removal
Authors: Kumar S.
Published: April 2021

The development of new generation photocatalytic materials used for the betterment of human as well as environment. Perovskites and perovskites related nano-hetero-junction shows great interest for photocatalytic organic and inorganic pollutant removal. This chapter discusses its crystalline structures varying from cubic (high symmetry) to triclinic (very low symmetry). Various methods have been utilized for synthesis of perovskites such as sol-gel, hydrothermal, vapor deposition methods, solid-state reaction routs from oxide and high pressure technique. The first technique is used for the synthesis of perovskite is ceramic route in which the mixture of oxide was treated at high temperature and processed later by ceramic powder method. Various photocatalyst such as nitrides, sulphides, phosphides, oxide and mixed oxide are employed for photocatalytic water splitting or hydrogen generation. Future perspectives of perovskite-related photocatalyst are included in this chapter.
Composite Ion Exchangers as New Age Photocatalyst
Authors: Thakur M.
Published: April 2021

The innovation of different technologies and emphasis on development of new techniques is indispensable to improve the quality of water globally. Photocatalysis is one of the major techniques explored now a days for the exclusion of water impurities using solar light. Different types of photocatalysts have been employed for the removal of dyes, heavy metals, pesticides from aqueous system. During the last few years, nanocomposite ion exchangers were used as a photocatalyst for the removal of organic pollutants. This chapter includes detailed information about introduction of pollutants into the water system, nanocomposite ion exchangers and photocatalysis removal. Nanocomposite ion exchangers effectively degrade various pollutants present in the marine system. These nanocomposites have also been used in different areas such as fuel cell, sensor, nuclear separation and heavy metal removal etc. Therefore, nanocomposite ion exchangers are a new age photocatalyst with unique and effective properties.
Dissociatieve anesthesie bij paarden in de praktijk
Authors: Schauvliege S. , Gasthuys F.
Published: April 2021

Sinds thiopental van de Belgische markt is verdwenen, worden de dissociatieve anesthetica (ketamine en tiletamine) steeds frequenter gebruikt voor de anesthesie van paarden onder praktijkomstandigheden. Na sedatie met een α2-agonist, eventueel gecombineerd met een opioïd, wordt de anesthesie geïnduceerd met een combinatie van het dissociatief anestheticum en een benzodiazepine. Met ketamine bekomt men een chirurgische anesthesieduur van 10 à 20 minuten. Tiletamine werkt wat langer maar kan resulteren in een minder goede recovery. Indien de geplande anesthesieduur langer is (20 à 60 minuten), wordt na inductie van de anesthesie het beste overgegaan op een infuus, bijvoorbeeld met ketamine, een α2-agonist en een spierrelaxans, de zogenaamde triple drip. Waar mogelijk gebruikt men het beste ook locoregionale anesthesie. Aangezien vele anesthetica niet geregistreerd zijn voor het gebruik bij voedselproducerende paarden, dient een aangepaste wachttijd ingesteld te worden en moet, naargelang het product, een toedienings- en verschaffingsdocument opgemaakt of het paspoort van het paard aangevuld worden.
Antimicrobiële resistentie: een vlag die vele ladingen dekt
Authors: Boyen F. , Pasmans F. , Butaye P. , Haesebrouck F.
Published: April 2021

Antibiotica chemotherapeutica met een antibacteriële werking zijn niet meer weg te denken uit de veterinaire geneeskunde. De opkomst van antimicrobiële resistentie vormt een bedreiging voor de gezondheid van zowel mens als dier en het voortbestaan van de dierlijke voedselproductie zoals wij die vandaag kennen. In dit overzicht worden enkele basistermen en begrippen met betrekking tot antimicrobiële resistentie toegelicht. Bovendien wordt er een samenvatting gegeven van de manier waarop resistentie kan worden bepaald en hoe de resultaten van gevoeligheidstesten dienen te worden geïnterpreteerd.
Vraag & Antwoord
Authors: Oosterlinck M. , Pille F. , Rijsselaere T. , Boyen F.
Published: April 2021

Hematogene infectieuze fysitis bij een veulen
Invloed van leeftijd op de spermakwaliteit van de reu
Antimicrobiële resistentie bij kalveren met diarree
Canien lymfoom: een retrospectieve studie (2009 – 2010)
Authors: Mortier F. , Daminet S. , Vandenabeele S. , Van de Maele I.
Published: April 2021

Het medisch dossier van 56 honden met een cytologische en/of histologische diagnose van lymfoom gesteld tussen 1 januari 2009 en 31 december 2010 werd bestudeerd. De meeste honden waren van middelbare leeftijd of ouder en hadden multicentrisch lymfoom (n=36). De meerderheid van de honden bevond zich in stage III tot V (n=55) en in substage b (n=43). Hematologie, serumbiochemie, urineanalyse, serumeiwit-elektroforese, thoraxradiografieën en/of abdominale echografie werden uitgevoerd en de resultaten kwamen grotendeels overeen met deze in de literatuur. Bij 80% (n=45) werd een behandeling opgestart. Na de diagnose was de mediane overlevingstijd voor 62% van de honden (n=28) die enkel met prednisolone werd behandeld, 32 dagen (3 – 224 dagen). Voor 24% (n=11) behandeld met chemotherapie was dit 119 dagen (11 – 273 dagen). Bij de resterende zes behandelde honden (13%) werd de macroscopische tumor verwijderd middels chirurgie. Drie van deze honden werden nadien behandeld met prednisolone. De mediane overlevingstijd van deze zes honden bedroeg 47 dagen (0 – 669 dagen). Van de honden die met chemotherapie werden behandeld, was de mediane overlevingstijd significant langer dan van de honden die enkel met prednisolone werden behandeld, ondanks het feit dat negatief prognostische factoren aanwezig waren bij alle honden die chemotherapie ondergingen.
Mediastinaal thymoma bij een konijn met intermitterende bilaterale exoftalmie
Authors: Storms G. , Janssens G. , Ducatelle R.
Published: April 2021

Een acht jaar oud, mannelijk, gecastreerd, middenslagkonijn werd aangeboden met een bilaterale, intermitterende en stressgerelateerde exoftalmie. Op de thoraxradiografieën was een massa zichtbaar in het craniale mediastinum. Het konijn werd kort daarna geëuthanaseerd omwille van ernstige ademhalingsproblemen. Tijdens het pathologisch onderzoek werd een grote, goed omschreven, niervormige massa aangetroffen craniaal van het hart, zonder macroscopische afwijkingen aan andere organen. Op histologisch onderzoek waren zowel kleine als middelgrote ronde cellen aanwezig, ingebed in een fijn reticulair stroma. Het cytoplasma van de tumorcellen kleurde positief aan voor cytokeratine, wat de diagnose van thymoma bevestigde en een lymfoma uitsloot.
Vraag & Antwoord
Authors: Claerebout E. , Wydooghe E. , Piepers S.
Published: April 2021

Leishmania bij honden in België
Behandeling van schijndracht bij de teef
Prototheca en geassocieerde uiergezondheidsproblemen
Peningkatan Kinerja Aparat Kampung melalui Pelatihan Komputer di Kampung Semurut
Authors: Salman Muhamad Ali
Published: April 2021

Abstrak: Penelitian ini bertujuan untuk mengetahui perencanaan, pelaksanaan dan hasil program pelatihan komputer dalam meningkatkan kinerja Aparat Kampung di Kampung Semurut. Jenis penelitian adalah deskriptif kualitatif. Sumber data menggunakan wawancara, pengamatan, dan analisis dokumen. Tehnik analisis data menggunakan reduksi data, display data dan verifikasi data. Hasil penelitian menunjukkan bahwa (1). Perencanaan: adanya rapat internal oleh Aparat kampung. Adanya rapat gabungan antara Aparat Kampung bersama PKBM Pusaka Indonesia, (2). Pelaksanaan: Pelatihan terselenggara sesuai  jadwal. Peserta pelatihan aktif bertanya. Ada beberapa peserta pelatihan yang belum mengetahui dasar-dasar komputer bahkan cara mengoperasikan komputer, (3). Hasilnya: Peserta pelatihan mampu mengoperasikan komputer. Peserta pelatihan mampu menggunakan dasar-dasar Microsoft word, Microsoft excel dan Microsoft power point. Kepercayaan diri Aparat Kampung meningkat. Pekerjaan yang bersifat administasi dapat dikerjakan secara langsung tanpa menggunakan jasa pengetikan. Penyelenggaraan Pelatihan komputer menunjukkan adanya keberhasilan dengan meningkatnya kinerja Aparat Kampung di bidang administrasi. Village Agency Performance Improvement through Computer Trainingin Semurut Village Abstract: This study aims to determine the planning, implementation and results of computer training programs in improving the performance of village officials in Semurut Village. This type of research is descriptive qualitative. Sources of data using interviews, observations, and document analysis. Data analysis techniques used data reduction, data display and data verification. The results showed that (1). Planning: an internal meeting by village officials. There was a joint meeting between village officials and PKBM Pusaka Indonesia, (2). Implementation: The training is held according to schedule. Active training participants ask questions. There are some training participants who do not know the basics of computers and even how to operate computers, (3). The result: The trainees are able to operate computers. The training participants are able to use the basics of Microsoft word, Microsoft excel and Microsoft power point. The village apparatus' self-confidence increased. Administrative work can be done directly without using typing services. The implementation of computer training has shown success with the increase in the performance of village officials in the administration sector.
Systematic Review: Strategi Pemberdayaan Pelaku UMKM Menuju Ekonomi Digital Melalui Aksi Sosial
Authors: Fuadi Debi S , Akhyadi Ade Sadikin , Saripah Iip
Published: April 2021

Abstrak: Seiring perubahan perilaku konsumen di era digital menjadi satu peluang bagi pelaku usaha kecil dan menengah (UMKM) dalam memperluas akses pasar serta menjadi tantangan beradaptasi. Penelitian ini bertujuan untuk menganalisis strategi pemberdayaan pelaku UMKM go digital melalui aksi sosial yaitu Volunter, Komunitas UMKM, Klinik ekonomi digital, Model Desa Cerdas dan Pahlawan ekonomi dengan melakukan pendampingan secara berkelanjutan serta berkolaborasi dengan berbagai pihak. Penelitian ini menggunakan pendekatan systematic review melalui beberapa tahapan yaitu identifikasi pertanyaan penelitiaan, menetapkan data base hasil penelitian, seleksi hasil penelitian yang relevan dan terindeks, ekstarsi data, sintasi hasil dengan metode naratif dan penyajian data. Dari hasil analisis peran komunitas sosial memberikan kontribusi serta solusi terhadap permasalahan yang dihadapi untuk menekan kesenjangan arus digitalisasi antara desa dan kota. Manfaat dari penelitian ini bisa dijadikan bahan referensi dalam merancang kurikulum pengembangan dan pemberdayaan pelaku UMKM dalam menuju digitalisasi. Systematic Review: Strategies for Empowering UMKM Subject Toward a Digital Economy through Social ActionAbstract: Along with changes in consumer behavior in the digital era, there is an opportunity for small and medium enterprises (UMKM) to expand market access and become a challenge to adapt. This study aims to analyze the strategy for empowering UMKM subject to go digital through social actions, namely Volunteers, UMKM Communities, Digital Economy Clinics, Smart Village Models and Economic Heroes by providing ongoing assistance and collaborating with various parties. This study uses a systematic review approach through several stages, namely identification of research questions, establishing a data base of research results, selecting relevant and indexed research results, data extraction, synthesis of results using narrative methods and data presentation. From the results of the analysis of the role of the social community in contributing and solutions to the problems faced in reducing the gap in the flow of digitalization between villages and cities. The benefits of this research can be used as reference material in designing a curriculum for developing and empowering UMKM subject towards digitalization.
Digital learning transformation in strengthening self-resilience
Authors: Armawi Armaidy , Makmur Chesa Syaqira , Septiyanti Murni , Wahidin Darto
Published: April 2021

The Covid-19 pandemic has forced teachers to conduct learning activities online through digital technology. As they are accustomed to the conventional or offline learning process, this digital-based learning transformation has resulted in teachers experiencing shock culture and students affected immensely. The current research aims to describe the strategies applied for digital-based learning, examine challenges in digital-based learning, and identify digital-based learning impacts on students' self-resilience. It employs the qualitative research method, and the data consist of primary and secondary data. The primary one is derived from the observation of focus group discussion and documentation. The secondary one is in the form of references from books, journals, and articles. By data reduction and conclusion drawing in a descriptive qualitative analysis, the findings show that using learning application varies depending on the teachers' capability and convenience, and agreement from the institution. The only learning media used in the format are videos and pictures, considering the weak internet bandwidth and limited internet quota. The challenges in digital-based learning should be the point of attention for both teachers and parents. The impacts resulted from this digital-based learning system on students' self-resilience are considerable. Supports from family and school must be wholly given to reinforce students' self-resilience.
Internalizing character education through javanese traditional dance to realize child-friendly school
Authors: Supeni Siti , Harini Setyasih
Published: April 2021

The aims of the research are to (1) identify character education in various Javanese traditional dance, (2) to analyze the needs, output, problems, and learning objectives of child-friendly schools (CFS) in implementing character education based on regional dance, and (3) to identify types of Javanese traditional dance values. The methods of collecting the data used literary studies, interviews, surveys, observations, and documentation. In analyzing the data, the researchers employed Research Development model. Model of regional cultural development based on character education is supported through a psychological, educative, and socio-cultural approach, with qualitative descriptive analysis implemented in 2020. The research findings show that (1) identification character education in various Javanese traditional dance, (2) the needs, output, problems, and learning objectives of child-friendly schools (CFS) in implementing character education based on regional dance, and (3) types of Javanese traditional dance values. The implication of the research is the implementation of character education for elementary school students.
Development of harvard step test an-515 based on digital integrated technology
Authors: Nuryadin Arief , Siswantoyo Siswantoyo
Published: April 2021

For practitioners and academission in sports, knowing the level of physical fitness is very important. One way to measure it by using the Harvard Step Test. However, measuring physical fitness using the manual Harvard Step Test often has several drawbacks. One of them is an error in the process of calculating the pulse, which results in the final result of physical fitness measurements to be less accurate. Therefore, it is necessary to develop a valid and reliable Harvard Step Test measuring instrument based on integrated digital technology. This research uses research and development methods. The small-scale trial used 10 samples from the Regional Leadership 53 Tapak Suci Klaten Pencak silat branch, while the large scale used samples from the Bantul Anggar Branch and the Jaya Raya Sleman Badminton Board. The data analysis technique used is qualitative and quantitative analysis, while the effectiveness test used the one-tailed paired sample t-test. This research resulted in a product in the form of a Harvard Step Test based on integrated digital technology which is equipped with a manual. The trial results and effectiveness show that the Harvard Step Test, which is based on integrated digital technology, is effective to measure physical fitness in all age groups. PENGEMBANGAN HARVARD STEP TES AN-515 BERBASIS DIGITAL TEKNOLOGI TERINTEGRASI AbstrakBagi praktisi dan akademisi di bidang olahraga, mengetahui tingkat kebugaran jasmani merupakan hal yang sangat penting. Salah satu cara mengukurnya adalah dengan menggunakan Harvard Step Test. Akan tetapi, mengukur kebugaran jasmani menggunakan Harvard Step Test manual seringkali memiliki beberapa kekurangan. Salah satunya adalah kesalahan dalam proses perhitungan denyut nadi, yang mengakibatkan hasil akhir dari pengukuran kebugaran jasmani menjadi kurang akurat. Oleh sebab itu, perlu dikembangkan alat ukur Harvard Step Test berbasis digital teknologi terintegrasi yang valid dan reliabel. Penelitian ini menggunakan metode penelitian dan pengembangan. Uji coba skala kecil menggunakan sampel dari cabang Pencak silat Pimpinan Daerah 53 Tapak Suci Klaten sebanyak 10 orang, sedangkan skala besar menggunakan sampel dari Cabang Anggar Bantul dan Pengurus Besar Bulutangkis Jaya Raya Sleman. Teknik analisis data yang digunakan adalah analisis kualitatif dan kuantitatif sedangkan pada uji efektivitas menggunakan uji one-tailed paired sample t-Test. Penelitian ini menghasilkan produk berupa Harvard Step Test berbasis digital teknologi terintegrasi yang dilengkapi buku panduan. Hasil ujicoba dan efektifitas menunjukkan bahwa Harvard Step Test yang berbasis digital teknologi terintegrasi efektif digunakan untuk mengukur kebugaran jasmani dalam semua kelompok usia.
Does E-Learning Content Design Affect Student Learning Outcomes?
Authors: Hidayati Nisail Mugni
Published: April 2021

This study aims to determine and analyze the effect of e-learning content design in the economic subject on learning outcomes moderated by student gender. The level of content design is measured through indicators of interface design, functionality, system support, usability, convenience, satisfaction, goals, active learning style, basic concepts, problem solving and experience. The level of learning outcomes is measured through the indicator of the test score results. This study uses an explanatory survey method with data collection techniques through questionnaires those are distributed to 197 students of the Social Sciences major with a sample of 132 students at SMA Negeri 1 Rengasdengklok. The data analysis technique uses descriptive statistics, inferential statistics and regression analysis. The results of this study indicate 1) The level of content design has a positive effect on the level of learning outcomes. The higher the level of e-learning content design on the economic subject, the higher the learning outcomes will be obtained by students. 2) Gender does not moderate the positive effect of the level of content design on the level of learning outcomes. However, the positive influence on content design for the male group is stronger.
Dairy productivity in milking in the morning, afternoon and total in a semi-stable goat system
Authors: Hurtado-Lugo Naudin , Nolasco-Serna Christian , Montes Vergara Donicer
Published: April 2021

Objective. The objective of this work was to calculate descriptive statistics of milk yields. Materials and methods. 6733 milk controls were carried in the morning, afternoon and total/day milkings produced by 21 goats saanen, alpina americana and togenburen breeds in a semi stable system located in the Ocaña region, Norte de Santander; Results. Milk yield (milliliters) in the morning, afternoon and daily total was 564.99±242.38, 259.30±112.81 and 824.29±350.07. Also, it was observed that in the non-parametric statistical tests of the probability distribution of the phenotypic expression of the morning, afternoon and daily total yield, they presented highly significant normalities (p<0.0001). Conclusions. the results obtained are in the expected for the species, also, it is suggested that the calculated yield values were possibly influenced by effects not considered in the study.
Translation and Validation of “Brief Bedside Dysphagia Screening Test” in a Greek Sample of Neurological Patients
Authors:   “Help at Home” Service, Municipality of Saronikos, Sakka Keratea, PO box 50086, PC 19001, Athens, Greece, Demeneopoulou Sophia , Mantzorou Marianna ,   Department of Nursing, University of West Attica, Agiou Spiridonos, 12243 Egaleo, Athens, Greece;, Mandysova Petra ,   Department of Nursing, Faculty of Health Studies, University Pardubice, Studentská 95, 532 10 Pardubice, Czech Republic;, Margari Nikoletta ,   Department of Nursing, University of West Attica, Agiou Spiridonos, 12243 Egaleo, Athens, Greece;, Dokoutsidou Eleni ,   Department of Nursing, University of West Attica, Agiou Spiridonos, 12243 Egaleo, Athens, Greece;, Tsiligianni Aggeliki ,   General University Hospital of Larisa, 3 Adrianou, 41221 Larisa, Greece;, Tsiou Chrysoula ,   Department of Nursing, University of West Attica, Agiou Spiridonos, 12243 Egaleo, Athens, Greece;, Adamakidou Theodoula ,   Department of Nursing, University of West Attica, Agiou Spiridonos, 12243 Egaleo, Athens, Greece;
Published: April 2021

Dysphagia may become a threatening condition if not diagnosed and treated at an early stage. Healthcare professionals require simple, rapid, and reliable tools for the immediate evaluation of dysphagia in their daily clinical practice. The aim of the present study was the translation and validation of the “Brief Bedside Dysphagia Screening Test-Revised (BBDST-R)” tool in the Greek language in a sample of patients with neurological disorders. The present study was designed as a cross-sectional study conducted with a convenience sample of 80 patients. The BBDST-R tool contains eight items, and a positive response to an item implies that the patient might have dysphagia. The bedside assessment using the BBDST-R tool was conducted by a researcher previously trained for the tool usage. The translation and validation were conducted by following the relevant international standards. The researcher’s final assessment concerning the presence or absence of dysphagia was compared to the medical diagnosis as determined by a physician, which was set as a benchmark. The evaluation of BBDST-R was conducted by researching its diagnostic accuracy according to the guidelines for measures of diagnostic accuracy. Internal consistency was determined through Cronbach’s Alpha. The English version of the BBDST-R tool has been reliably translated into the Greek language. The prevalence of dysphagia in our sample was 62.5% (95% CI: 50%-72%). The observed high sensitivity [Sen = 98%/87%-99% (95% CI)] and high negative predictive value [NPV = 89%/77%-95% (95% CI)] indicated high validity of the screening tool at the acceptable levels of > 75% even for 95% CI. Cronbach’s Alpha internal consistency index for the 8 items of this tool presented an almost excellent value of 0.859. The results of the present study indicated that BBDST-R is a reliable and valid tool for application in the assessment of dysphagia in patients admitted in Greek hospitals and community-based individuals.
Gaming Your Mental Health: A Narrative Review on Mitigating Symptoms of Depression and Anxiety Using Commercial Video Games
Authors: Kowal Magdalena , Conroy Eoin , Ramsbottom Niall , Smithies Tim , Toth Adam , Campbell Mark
Published: April 2021

Globally, depression and anxiety are the two most prevalent mental health disorders. They occur both acutely and chronically, with various symptoms commonly expressed subclinically. The treatment gap and stigma associated with such mental health disorders are common issues encountered worldwide. Given the economic and health care service burden of mental illnesses, there is a heightened demand for accessible and cost-effective methods that prevent occurrence of mental health illnesses and facilitate coping with mental health illnesses. This demand has been exacerbated post the advent of the COVID-19 pandemic and the subsequent increase in incidence of mental health disorders. To address these demands, a growing body of research is exploring alternative solutions to traditional mental health treatment methods. Commercial video games have been shown to impart cognitive benefits to those playing regularly (ie, attention control, cognitive flexibility, and information processing). In this paper, we specifically focus on the mental health benefits associated with playing commercial video games to address symptoms of depression and anxiety. In light of the current research, we conclude that commercial video games show great promise as inexpensive, readily accessible, internationally available, effective, and stigma-free resources for the mitigation of some mental health issues in the absence of, or in addition to, traditional therapeutic treatments.
Leisure and Problem Gaming Behaviors Among Children and Adolescents During School Closures Caused by COVID-19 in Hong Kong: Quantitative Cross-sectional Survey Study
Authors: Zhu Shimin , Zhuang Yanqiong , Lee Paul , Li Jessica Chi-Mei , Wong Paul W C
Published: April 2021

Background

School closures during the COVID-19 pandemic may have exacerbated students’ loneliness, addictive gaming behaviors, and poor mental health. These mental health issues confronting young people are of public concern.

Objective

This study aimed to examine the associations between loneliness and gaming addiction behaviors among young people in Hong Kong and to investigate how familial factors, psychological distress, and gender differences moderate these relationships.

Methods

This cross-sectional study was conducted in June 2020 when schools reopened after 6 months of school closures. Participants included 2863 children and adolescents in primary (Grades 4 to 6) and secondary (Grades 7 and 8) schools (female participants: 1502/2863, 52.5%). Chi-square tests, one-way analyses of variance, and independent-samples t tests were performed to compare the differences of distribution in gaming addiction behaviors across gender, age, and other sociodemographic characteristics. Multinomial logistic regression analyses were conducted to identify factors that relate to excessive or pathological gaming behaviors separately, in comparison with leisure gaming.

Results

A total of 83.0% (2377/2863) of the participants played video games during the COVID-19 pandemic. The prevalence of excessive and pathological game addiction behaviors was 20.9% (597/2863) and 5.3% (153/2863), respectively. More male students had gaming addiction symptoms than female students. The multinomial logistic regressions showed that feeling lonely was associated with more problematic gaming behaviors, and the association was stronger for older female students. Low socioeconomic status, less parental support and less supervision, and poor mental health were risk factors for gaming addiction behaviors, especially among primary school students.

Conclusions

Loneliness was associated with gaming addiction behaviors; the findings from this study suggested that this association was similar across gender and age groups among young people. Familial support and supervision during school closures can protect young people from developing problematic gaming behaviors. Results of this study have implications for prevention and early intervention on behalf of policy makers and game developers.
Current State of Dental Informatics in the Field of Health Information Systems: Systematic Review (Preprint)
Authors: Ballester Benoit , Bukiet Frédéric , Dufour Jean-Charles
Published: April 2021

BACKGROUND

Over the past 50 years, dental informatics has developed significantly in the field of health information systems. Accordingly, several studies have been conducted on standardized clinical coding systems, data capture, and clinical data reuse in dentistry.

OBJECTIVE

The primary objective of this systematic review was to summarize studies on standardized clinical coding systems and electronic dental record (EDR) data capture in dentistry. The secondary objective was to explore the practical implications of reusing EDR data in clinical decision support systems, quality measure development, and clinical research.

METHODS

Based on the definition of health information systems, we divided the literature search into 3 specific sub-searches: “standardized clinical coding systems,” “data capture,” and “reuse of routine patient care data.” PubMed and Web of Science were searched for peer-reviewed articles. The review was conducted following the PRISMA protocol.

RESULTS

A total of 43 articles were identified for inclusion in the review. Of these, 15 were related to “standardized clinical coding systems,” 15 to “data capture,” and 13 to “reuse of routine patient care data.” Articles related to standardized clinical coding systems focused on the design and/or development of proposed systems, on their evaluation and validation, on their adoption in academic settings, and on user perception. Articles related to data capture addressed the issue of data completeness, evaluated user interfaces and workflow integration, and proposed technical solutions. Finally, articles related to reuse of routine patient care data focused on clinical decision support systems centered on patient care, institutional or population-based health monitoring support systems, and clinical research.

CONCLUSIONS

While the development of health information systems, and especially standardized clinical coding systems, has led to significant progress in research and quality measures, the vast majority of reviewed articles were published in the US. Clinical decision support systems that reuse EDR data have been little studied. Likewise, few studies have examined the working environment of dental practitioners or the pedagogical value of using health information systems in dentistry.