bluuebunny/crossref_metadata_2025 huggingface dataset:
Alterations in Galanin-Like Immunoreactivity in the Enteric Nervous System of the Porcine Stomach Following Acrylamide Supplementation
Authors: Palus Katarzyna , Makowska Krystyna , Całka Jarosław
Published: July 2019

In recent years, a significant increase in the consumption of products containing large amounts of acrylamide (e.g., chips, fries, coffee), especially among young people has been noted. The present study was created to establish the impact of acrylamide supplementation, in tolerable daily intake (TDI) dose and a dose ten times higher than TDI, on the population of galanin-like immunoreactive (GAL-LI) stomach neurons in pigs. Additionally, in the present study, the possible functional co-operation of GAL with other neuroactive substances and their role in acrylamide intoxication was investigated. Using double-labelling immunohistochemistry, alterations in the expression of GAL were examined in the porcine stomach enteric neurons after low and high doses of acrylamide supplementation. Generally, upregulation in GAL-LI immunoreactivity in both myenteric and submucous plexuses was noted in all stomach fragments studied. Additionally, the proportion of GAL-expressing cell bodies simultaneously immunoreactive to vasoactive intestinal peptide (VIP), neuronal nitric oxide synthase (nNOS) and cocaine- and amphetamine- regulated transcript peptide (CART) also increased. The results suggest neurotrophic or/and neuroprotective properties of GAL and possible co-operation of GAL with VIP, nNOS, CART in the recovery processes in the stomach enteric nervous system (ENS) neurons following acrylamide intoxication.
Comparison between Slow Freezing and Vitrification for Human Ovarian Tissue Cryopreservation and Xenotransplantation
Authors: Lee Sanghoon , Ryu Ki-Jin , Kim Boram , Kang Dahyeon , Kim Yoon Young , Kim Tak
Published: July 2019

Two methods for the cryopreservation of human ovarian tissue were compared using a xenotransplantation model to establish a safe and effective cryopreservation method. Ovarian tissues were obtained from women who underwent benign ovarian surgery in the gynecology research unit of a university hospital. The tissues were transplanted into 112 ovariectomized female severe combined immunodeficient mice 4 weeks after slow freezing or vitrification cryopreservation. Tissues were retrieved 4 weeks later. Primordial follicular counts decreased after cryopreservation and xenotransplantation, and were significantly higher in the slow freezing group than in the vitrification group (p < 0.001). Immunohistochemistry and TUNEL assay showed that the Ki-67 and CD31 markers of follicular proliferation and angiogenesis were higher in the slow freezing group (p < 0.001 and p = 0.006, respectively) and DNA damage was greater in the vitrification group (p < 0.001). Western blotting showed that vitrification increased cellular apoptosis. Anti-Müllerian hormone expression was low in transplanted samples subjected to both cryopreservation techniques. Electron microscopy revealed primordial follicle deformation in the vitrification group. Slow freezing for ovarian tissue cryopreservation is superior to vitrification in terms of follicle survival and growth after xenotransplantation. These results will be useful for fertility preservation in female cancer patients.
Development of Drought-Tolerant Transgenic Wheat: Achievements and Limitations
Authors: Khan Shahbaz , Anwar Sumera , Yu Shaobo , Sun Min , Yang Zhenping , Gao Zhi-qiang
Published: July 2019

Crop yield improvement is necessary to keep pace with increasing demand for food. Due to climatic variability, the incidence of drought stress at crop growth stages is becoming a major hindering factor to yield improvement. New techniques are required to increase drought tolerance along with improved yield. Genetic modification for increasing drought tolerance is highly desirable, and genetic engineering for drought tolerance requires the expression of certain stress-related genes. Genes have been identified which confer drought tolerance and improve plant growth and survival in transgenic wheat. However, less research has been conducted for the development of transgenic wheat as compared to rice, maize, and other staple food. Furthermore, enhanced tolerance to drought without any yield penalty is a major task of genetic engineering. In this review, we have focused on the progress in the development of transgenic wheat cultivars for improving drought tolerance and discussed the physiological mechanisms and testing of their tolerance in response to inserted genes under control or field conditions.
Quantifying the Potential for Future Gene Therapy to Lower Lifetime Risk of Polygenic Late-Onset Diseases
Authors: Oliynyk Roman Teo
Published: July 2019

Gene therapy techniques and genetic knowledge may sufficiently advance, within the next few decades, to support prophylactic gene therapy for the prevention of polygenic late-onset diseases. The risk of these diseases may, hypothetically, be lowered by correcting the effects of a subset of common low effect gene variants. In this paper, simulations show that if such gene therapy were to become technically possible; and if the incidences of the treated diseases follow the proportional hazards model with a multiplicative genetic architecture composed of a sufficient number of common small effect gene variants, then: (a) late-onset diseases with the highest familial heritability will have the largest number of variants available for editing; (b) diseases that currently have the highest lifetime risk, particularly those with the highest incidence rate continuing into older ages, will prove the most challenging cases in lowering lifetime risk and delaying the age of onset at a population-wide level; (c) diseases that are characterized by the lowest lifetime risk will show the strongest and longest-lasting response to such therapies; and (d) longer life expectancy is associated with a higher lifetime risk of these diseases, and this tendency, while delayed, will continue after therapy.
Correlations between Genetic Polymorphisms in Long Non-Coding RNA PRNCR1 and Gastric Cancer Risk in a Korean Population
Authors: Hong Jang Hee , Jin Eun-Heui , Kang Hyojin , Chang In Ae , Lee Sang-Il , Sung Jae Kyu
Published: July 2019

We evaluated the association between prostate cancer non-coding RNA 1 (PRNCR1) polymorphisms and the risk of developing gastric cancer (GC) and GC subgroups in Korea. A case–control study was conducted with 437 GC patients and 357 healthy controls using a TaqMan genotyping assay. A chi-squared test, binary logistic regression, and genetic models were used to explore the association between five PRNCR1 polymorphisms and GC risk. After adjusting for gender and age, overall analyses using the recessive model indicated that the rs13252298 GG genotype was significantly associated with increased risk of intestinal-type gastric cancer (IGC). In the stratification analyses, the recessive model indicated that the rs1016343 TT genotype was significantly associated with decreased GC risk in individuals aged <60 years showing lymph node metastasis (LNM)-negative results. The rs13252298 GG genotype in the recessive model showed increased GC risk in subjects aged ≥60 years showing LNM-positive results and those aged ≥60 years in tumor stage III. In the dominant model, the rs16901946 combined genotype (AG/GG) was significantly associated with increased GC risk in subjects aged <60 years with tumor stage III. In the recessive model, the rs16901946 GG genotype was associated with decreased risk of GC and IGC in males aged ≥60 years. Thus, genetic variations in PRNCR1 may contribute to susceptibility to GC.
A Fixed Point Result with a Contractive Iterate at a Point
Authors: Alqahtani Badr , Fulga Andreea , Karapınar Erdal
Published: July 2019

In this manuscript, we define generalized Kincses-Totik type contractions within the context of metric space and consider the existence of a fixed point for such operators. Kincses-Totik type contractions extends the renowned Banach contraction mapping principle in different aspects. First, the continuity condition for the considered mapping is not required. Second, the contraction inequality contains all possible geometrical distances. Third, the contraction inequality is formulated for some iteration of the considered operator, instead of the dealing with the given operator. Fourth and last, the iteration number may vary for each point in the domain of the operator for which we look for a fixed point. Consequently, the proved results generalize the acknowledged results in the field, including the well-known theorems of Seghal, Kincses-Totik, and Banach-Caccioppoli. We present two illustrative examples to support our results. As an application, we consider an Ulam-stability of one of our results.
Circumdatin-Aspyrone Conjugates from the Coral-Associated Aspergillus ochraceus LCJ11-102
Authors: Fan Yaqin , Zhou Yalin , Du Yuqi , Wang Yi , Fu Peng , Zhu Weiming
Published: July 2019

Ochrazepines A−D (1−4), four new conjugates dimerized from 2-hydroxycircumdatin C (5) and aspyrone (6) by a nucleophilic addition to epoxide, were isolated from the fermentation broth of the coral-associated Aspergillus ochraceus strain LCJ11-102. Their structures including absolute configurations were determined based on spectroscopic analysis and chemical methods. Compounds 1−4 were also obtained by the semisynthesis from a nucleophilic addition of 2-hydroxycircumdatin C (5) to aspyrone (6). New compound 1 exhibited cytotoxic activity against 10 human cancer cell lines while new compounds 2 and 4 selectively inhibited U251 (human glioblastoma cell line) and compound 3 was active against A673 (human rhabdomyoma cell line), U87 (human glioblastoma cell line), and Hep3B (human liver cancer cell line) with IC50 (half maximal inhibitory concentration) values of 2.5–11.3 μM among 26 tested human cancer cell lines.
Bioactive Compounds Isolated from Marine Bacterium Vibrio neocaledonicus and Their Enzyme Inhibitory Activities
Authors: Gómez-Betancur Isabel , Zhao Jianping , Tan Lin , Chen Chang , Yu Ge , Rey-Suárez Paola , Preciado Lina
Published: July 2019

Marine organisms are recognized as a source of compounds with interesting biological activities. Vibrio neocaledonicus has been reported on for its high effectiveness against corrosion in metals but it has been little studied for its chemical and biological activities. In this study, four compounds were isolated from V. neocaledonicus: indole (1); 1H-indole-3-carboxaldehyde (2); 4-hydroxybenzaldehyde (3) and Cyclo (-Pro-Tyr) (4); using a bioassay-guided method, since in a previous study it was found that the ethyl acetate extract was active on the enzymes acetylcholinesterase (AChE), alpha-glucosidase (AG) and xanthine oxidase (XO). The inhibitory activities of the three compounds against AChE, AG and XO was also evaluated. In addition, the enzymatic inhibitory activity of indole to the toxins from the venom of Bothrops asper was tested. Results showed that indole exhibited strong inhibitory activity to AG (IC50 = 18.65 ± 1.1 μM), to AChE, and XO (51.3% and 44.3% at 50 μg/mL, respectively). 1H-indole-3-carboxaldehyde displayed strong activity to XO (IC50 = 13.36 ± 0.39 μM). 4-hydroxybenzaldehyde showed moderate activity to XO (50.75% at 50 μg/mL) and weak activity to AChE (25.7% at 50 μg/mL). Furthermore, indole showed a significant in vitro inhibition to the coagulant effect induced by 1.0 μg of venom. The findings were supported by molecular docking. This is the first comprehensive report on the chemistry of V. neocaledonicus and the bioactivity of its metabolites.
Extraction and Characterization of Alginate from an Edible Brown Seaweed (Cystoseira barbata) Harvested in the Romanian Black Sea
Authors: Trica Bogdan , Delattre Cédric , Gros Fabrice , Ursu Alina Violeta , Dobre Tanase , Djelveh Gholamreza , Michaud Philippe , Oancea Florin
Published: July 2019

Cystoseira barbata is an edible brown seaweed, traditionally used in the Black Sea area as functional food. Both alginate and brown seaweed biomass are well known for their potential use as adsorbents for heavy metals. Alginate was extracted from C. barbata recovered from the Romanian coast on the Black Sea with a yield of 19 ± 1.5% (w/w). The structural data for the polysaccharide was obtained by HPSEC-MALS, 1H-NMR. The M/G ratio was determined to be 0.64 with a molecular weight of 126.6 kDa with an intrinsic viscosity of 406.2 mL/g. Alginate beads were used and their adsorption capacity with respect to Pb2+ and Cu2+ ions was determined. The adsorption kinetics of C. barbata dry biomass was evaluated and it was shown to have an adsorption capacity of 279.2 ± 7.5 mg/g with respect to Pb2+, and 69.3 ± 2 with respect to Cu2+. Alginate in the form of beads adsorbs a maximum of 454 ± 4.7 mg/g of Pb2+ ions and 107.3 ± 1.7 mg/g of Cu2+ ions.
A Critical Analysis of the Exercise Prescription and Return to Activity Advice That Is Provided in Patient Information Leaflets Following Lumbar Spine Surgery
Authors: Low Matthew , Burgess Louise C. , Wainwright Thomas W.
Published: July 2019

Background and objectives: Lumbar spine surgery may be considered if pharmacologic, rehabilitation and interventional approaches cannot provide sufficient recovery from low back-related pain. Postoperative physiotherapy treatment in England is often accompanied by patient information leaflets, which contain important rehabilitation advice. However, in order to be an effective instrument for patients, the information provided in these leaflets must be up to date and based on the best available evidence and clinical practice. This study aims to critically analyse the current postoperative aspects of rehabilitation (exercise prescription and return to normal activity) that are provided in patient information leaflets in England as part of an evaluation of current practice following lumbar spine surgery. Materials and Methods: Patient information leaflets from English National Health Service (NHS) hospitals performing lumbar spine surgery were sourced online. A content analysis was conducted to collect data on postoperative exercise prescription and return to normal activities. Results: Thirty-two patient information leaflets on lumbar surgery were sourced (fusion, n = 11; decompression, n = 15; all lumbar procedures, n = 6). Many of the exercises prescribed within the leaflets were not based on evidence of clinical best practice and lacked a relationship to functional activity. Return to normal activity advice was also wide ranging, with considerable variation in the recommendations and definitions provided. Conclusions: This study highlights a clear variation in the recommendations of exercise prescription, dosage and returning to normal activities following lumbar spine surgery. Future work should focus on providing a consistent and patient-centred approach to recovery.
HD-AGPs as Speciation Genes: Positive Selection on a Proline-Rich Domain in Non-Hybridizing Species of Petunia, Solanum, and Nicotiana
Authors: Callaway Tara D. , Singh-Cundy Anu
Published: July 2019

Transmitting tissue-specific proteins (TTS proteins) are abundant in the extracellular matrix of Nicotiana pistils, and vital for optimal pollen tube growth and seed set. We have identified orthologs from several species in the Solanaceae, including Petunia axillaris axillaris and Petunia integrifolia. We refer to TTS proteins and their orthologs as histidine domain-arabinogalactan proteins (HD-AGPs). HD-AGPs have distinctive domains, including a small histidine-rich region and a C-terminal PAC domain. Pairwise comparisons between HD-AGPs of 15 species belonging to Petunia, Nicotiana, and Solanum show that the his-domain and PAC domain are under purifying selection. In contrast, a proline-rich domain (HV2) is conserved among cross-hybridizing species, but variant in species-pairs that are reproductively isolated by post-pollination pre-fertilization reproductive barriers. In particular, variation in a tetrapeptide motif (XKPP) is systematically correlated with the presence of an interspecific reproductive barrier. Ka/Ks ratios are not informative at the infrageneric level, but the ratios reveal a clear signature of positive selection on two hypervariable domains (HV1 and HV2) when HD-AGPs from five solanaceous genera are compared. We propose that sequence divergence in the hypervariable domains of HD-AGPs reinforces sympatric speciation in incipient species that may have first diverged as a consequence of pollinator preferences or other ecological factors.
High Precision Compensation for a Total Reflection Prism Laser Gyro Bias in Consideration of High Frequency Oscillator Voltage
Authors: Tao Yuanbo , Li Sihai , Zheng Jiangtao , Wu Feng , Fu Qiangwen
Published: July 2019

Traditional compensation methods based on temperature-related parameters are not effective for complex total reflection prism laser gyro (TRPLG) bias variation. Because the high frequency oscillator voltage (UHFO) fundamentally affects the TRPLG bias, and the UHFO has a stronger correlation with the TRPLG bias when compared with the temperature, an introduction of UHFO into the TRPLG bias compensation can be evaluated. In consideration of the limitations of least squares (LS) regression and multivariate stepwise regression, we proposed a compensation method for TRPLG bias based on iterative re-weighted least squares support vector machine (IR-LSSVM) and compared with LS regression, stepwise regression, and LSSVM algorithm in large temperature cycling experiments. When temperature, slope of temperature variation, and UHFO were selected as inputs, the IR-LSSVM based on myriad weight function improved the TRPLG bias stability by 61.19% to reach the maximum and eliminated TRPLG bias drift. In addition, the UHFO proved to be the most important parameter in the process of TRPLG bias compensation; accordingly, it can alleviate the shortcomings of traditional compensation based on temperature-related parameters and can greatly improve the TRPLG bias stability.
Gait Phase Detection for Lower-Limb Exoskeletons using Foot Motion Data from a Single Inertial Measurement Unit in Hemiparetic Individuals
Authors: Sánchez Manchola Miguel D. , Bernal María J. Pinto , Munera Marcela , Cifuentes Carlos A.
Published: July 2019

Due to the recent rise in the use of lower-limb exoskeletons as an alternative for gait rehabilitation, gait phase detection has become an increasingly important feature in the control of these devices. In addition, highly functional, low-cost recovery devices are needed in developing countries, since limited budgets are allocated specifically for biomedical advances. To achieve this goal, this paper presents two gait phase partitioning algorithms that use motion data from a single inertial measurement unit (IMU) placed on the foot instep. For these data, sagittal angular velocity and linear acceleration signals were extracted from nine healthy subjects and nine pathological subjects. Pressure patterns from force sensitive resistors (FSR) instrumented on a custom insole were used as reference values. The performance of a threshold-based (TB) algorithm and a hidden Markov model (HMM) based algorithm, trained by means of subject-specific and standardized parameters approaches, were compared during treadmill walking tasks in terms of timing errors and the goodness index. The findings indicate that HMM outperforms TB for this hardware configuration. In addition, the HMM-based classifier trained by an intra-subject approach showed excellent reliability for the evaluation of mean time, i.e., its intra-class correlation coefficient (ICC) was greater than 0.75 . In conclusion, the HMM-based method proposed here can be implemented for gait phase recognition, such as to evaluate gait variability in patients and to control robotic orthoses for lower-limb rehabilitation.
Throughput Maximization for UAV-Enabled Relaying in Wireless Powered Communication Networks
Authors: Li Yinfeng , Yang Dingcheng , Xu Yu , Xiao Lin , Chen Haole
Published: July 2019

This paper investigates mobile relaying in wireless powered communication networks (WPCN), where an unmanned aerial vehicle (UAV) is employed to help information delivery from multiple sources to destination with communication channels severely blocked. The sources are low-power without energy supply. To support information transmission, the UAV acts as a hybrid access point (AP) to provide wireless power transfer (WPT) and information reception for sources. We set the issue of system throughput maximization as the optimization problem. On the one hand, the system is subject to the information causality constraint due to the dependent processes of information reception and transmission for the UAV. On the other hand, the sources are constrained by a so-called neutrality constraints due to the dependent processes of energy harvesting and energy consumption. In addition, we take account of the access delay issue of all ground nodes. Specifically, two paradigms of delay-tolerant case and delay-sensitive case are presented. However, the formulated problem including optimizations for time slot scheduling, power allocation and UAV trajectory is non-convex and thus is difficult to obtain its optimal solution. To tackle this problem, we apply the successive convex approximation (SCA) technique and propose an iterative algorithm by which a suboptimal solution can be achieved. Simulation results validate our proposed design, and show that the obtained suboptimal solution is high-quality, as compared to benchmark scheme.
Safe and Robust Mobile Robot Navigation in Uneven Indoor Environments
Authors: Wang Chaoqun , Wang Jiankun , Li Chenming , Ho Danny , Cheng Jiyu , Yan Tingfang , Meng Lili , Meng Max Q.-H.
Published: July 2019

Complex environments pose great challenges for autonomous mobile robot navigation. In this study, we address the problem of autonomous navigation in 3D environments with staircases and slopes. An integrated system for safe mobile robot navigation in 3D complex environments is presented and both the perception and navigation capabilities are incorporated into the modular and reusable framework. Firstly, to distinguish the slope from the staircase in the environment, the robot builds a 3D OctoMap of the environment with a novel Simultaneously Localization and Mapping (SLAM) framework using the information of wheel odometry, a 2D laser scanner, and an RGB-D camera. Then, we introduce the traversable map, which is generated by the multi-layer 2D maps extracted from the 3D OctoMap. This traversable map serves as the input for autonomous navigation when the robot faces slopes and staircases. Moreover, to enable robust robot navigation in 3D environments, a novel camera re-localization method based on regression forest towards stable 3D localization is incorporated into this framework. In addition, we utilize a variable step size Rapidly-exploring Random Tree (RRT) method which can adjust the exploring step size automatically without tuning this parameter manually according to the environment, so that the navigation efficiency is improved. The experiments are conducted in different kinds of environments and the output results demonstrate that the proposed system enables the robot to navigate efficiently and robustly in complex 3D environments.
Calibration of the Relative Orientation between Multiple Depth Cameras Based on a Three-Dimensional Target
Authors: Liu Zhe , Meng Zhaozong , Gao Nan , Zhang Zonghua
Published: July 2019

Depth cameras play a vital role in three-dimensional (3D) shape reconstruction, machine vision, augmented/virtual reality and other visual information-related fields. However, a single depth camera cannot obtain complete information about an object by itself due to the limitation of the camera’s field of view. Multiple depth cameras can solve this problem by acquiring depth information from different viewpoints. In order to do so, they need to be calibrated to be able to accurately obtain the complete 3D information. However, traditional chessboard-based planar targets are not well suited for calibrating the relative orientations between multiple depth cameras, because the coordinates of different depth cameras need to be unified into a single coordinate system, and the multiple camera systems with a specific angle have a very small overlapping field of view. In this paper, we propose a 3D target-based multiple depth camera calibration method. Each plane of the 3D target is used to calibrate an independent depth camera. All planes of the 3D target are unified into a single coordinate system, which means the feature points on the calibration plane are also in one unified coordinate system. Using this 3D target, multiple depth cameras can be calibrated simultaneously. In this paper, a method of precise calibration using lidar is proposed. This method is not only applicable to the 3D target designed for the purposes of this paper, but it can also be applied to all 3D calibration objects consisting of planar chessboards. This method can significantly reduce the calibration error compared with traditional camera calibration methods. In addition, in order to reduce the influence of the infrared transmitter of the depth camera and improve its calibration accuracy, the calibration process of the depth camera is optimized. A series of calibration experiments were carried out, and the experimental results demonstrated the reliability and effectiveness of the proposed method.
Mathematical Description of Rooting Profiles of Agricultural Crops and its Effect on Transpiration Prediction by a Hydrological Model
Authors: Metselaar Klaas , Pinheiro Everton Alves Rodrigues , de Jong van Lier Quirijn
Published: July 2019

The geometry of rooting systems is important for modeling water flows in the soil-plant-atmosphere continuum. Measured information about root density can be summarized in adjustable equations applied in hydrological models. We present such descriptive functions used to model root density distribution over depth and evaluate their quality of fit to measured crop root density profiles retrieved from the literature. An equation is presented to calculate the mean root half-distance as a function of depth from root length density profiles as used in single root models for water uptake. To assess the importance of the shape of the root length density profile in hydrological modeling, the sensitivity of actual transpiration predictions of a hydrological model to the shape of root length density profiles is analyzed using 38 years of meteorological data from Southeast Brazil. The cumulative root density distributions covering the most important agricultural crops (in terms of area) were found to be well described by the logistic function or the Gompertz function. Root length density distribution has a consistent effect on relative transpiration, hence on relative yield, but the common approach to predict transpiration reduction and irrigation requirement from soil water storage or average water content is shown to be only partially supported by simulation results.
MARGINAL DEHYDRATION OF FOLLICULAR FLUID IN PATIENTS WITH IVF AND ET AND ENDOCRINE DISORDERS
Authors: Trubnikova L.I. , Samoylova A.V. , Tadzhieva V.D. , Albutova M.L. , Marinova O.A. , Milaev S.G.
Published: July 2019

The aim of the paper is to identify the characteristics of follicular fluid (VF) structural composition using marginal dehydration method in patients with endocrine disorders and assisted reproductive technology (ART) for infertility treatment.
Materials and Methods. By means of marginal dehydration method the authors examined VF structural composition in 247 patients with tubal-endocrine infertility genesis. All the women were enrolled in IVF and PE programs. Among them, patients with endocrine disorders were identified (149 women).
Results. When studying the VF morphology by marginal dehydration method, the authors identified specifics of local VF organization in various forms of endocrine infertility. According to the local organization structure, the intensity of proliferative and destructive processes in the follicle was determined, and local ovarian homeostasis was assessed. These compositional peculiarities allowed us to suggest the possibility of using typical markers to predict outcomes of ART technologies and to personalize therapeutic approaches.
Keywords: infertility, IVF, endocrine disorders, follicular fluid, marginal dehydration, morphotypes.

Цель. Выявить особенности структуропостроения фолликулярной жидкости (ФЖ) методом краевой дегидратации у пациенток с эндокринными нарушениями, у которых для лечения бесплодия использованы методы вспомогательных репродуктивных технологий (ВРТ).
Материалы и методы. Методом краевой дегидратации исследовано структуропостроение ФЖ у 247 пациенток с трубно-эндокринным генезом бесплодия, вошедших в программу ЭКО и ПЭ. Среди них были выделены пациентки с эндокринными нарушениям (149 женщин).
Результаты. При исследовании морфологии ФЖ методом краевой дегидратации выявлены характерные особенности локальной организации ФЖ при различных формах эндокринного бесплодия. По структуре локальной организации определена степень выраженности пролиферативных и деструктивных процессов в фолликуле, дана оценка местного гомеостаза яичников. Эти особенности структуропостроения позволяют высказать предположение о возможности использования характерных маркеров для прогнозирования исходов технологий ВРТ и индивидуализировать терапевтические подходы.
Ключевые слова: бесплодие, ЭКО, эндокринные нарушения, фолликулярная жидкость, краевая дегидратация, морфотипы.
Accounting Outsourcing: Theoretical Bases and Methodological Provision
Authors: Grigoreva L. I.
Published: July 2019

The article presents the main components of the methodology and outsourcing model, which the adapted to the peculiarities of outsourcing accounting. There are the author’s method of analysis of the accounting department and the possibility of transition to outsourcing. The results of the researches were approbated using business process modeling. It allowed to make changes in accounting processes of the company, to form the adjusted reporting and to estimate result of transition to outsourcing without affecting and changing the real process of work of the company.
Directions of Modernization of Systems of Tax Administration in the Conditions of Application of Modern Information Technologies
Authors: Solekhzoda A. М.
Published: July 2019

The article reveals the most important areas of modernization of tax administration, discusses the role of modern information technologies, allowing to automate the entire process of tax administration. Taxes, as the main source of budget replenishment, are the most important factor in the formation of the financial base necessary to fulfill the tasks of the state. In this regard, the effectiveness of the modernization of the economy is directly related to science-based tax management.
Medicina
Authors: Zamora Luis Eduardo
Published: July 2019

La Facultad de Medicina y Cirugía de la UCIMED, está desarrollando estrategias educativas ya probadas en el mundo, con el fin de dar el salto educativo post Flexneriano que requiere el país, disminuyendo el atraso educativo. Se estima en unos 30 - 40 años, lo que significa, que lo que hoy realizamos en nuestro país en materia educativa, ya fue sustituido por técnicas modernas en el mundo.
Ultrasonido de Rodilla: consideraciones diagnósticas
Authors: Buján González Randall
Published: July 2019

El ultrasonido de rodilla donde no ha demostrado resultados contundentes es en la valoración de las partes intraarticulares, es decir meniscos y ligamentos cruzados, además del cartílago (condromalacia por ejemplo) y edema óseo asociado a trauma o a lesión cartilaginosa(lesión osteocondral), existen reportes de visualizaciones de ligamentos cruzados sonográficamente, principalmente el posterior, sin embargo no es posible una valoración adecuada del mismo, por lo que para la porción intraarticular de la rodilla sigue siendo la resonancia magnética (RM) el estudio a elección por su alta sensibilidad y especificidad.
Almacenamiento adecuado de Medicamentos
Authors: Sáenz Garcia Gustavo
Published: July 2019

Parte de esos requisitos tienen que ver con una gran cantidad de procesos y procedimientos llamados las Buenas Prácticas de Manufactura, las cuales plantean entre otros requerimientos, la necesidad que el producto farmacéutico cumpla con criterios de eficacia y seguridad a lo largo de su vida útil; de manera que estas condiciones garanticen la calidad del medicamento en este período de tiempo; en otras palabras, la fecha de vencimiento indica que en el tanto el medicamento cumpla con las condiciones adecuadas que respeten la integridad (envase y empaque); así como, la temperatura y humedad establecidas por el fabricante, se podrá garantizar que el medicamento mantiene su calidad y es seguro para su administración en seres humanos o animales, según sea haya definido.
Enfermedad celiaca
Authors: Mora Campos Julio , Villegas Barakat Mayra , Figueroa Protti Ana Lucía
Published: July 2019

La enfermedad celiaca es un desorden autoinmune provocado por el ataque de células inmunológicas contra las células de la mucosa intestinal. Esta activación inmunológica produce una inflamación crónica (constante) que termina atrofiando (destruyendo) las vellosidades de las células intestinales, las cuales son necesarias para absorber correctamente los alimentos. Esto provoca que no podamos absorber bien los nutrientes que están en la comida y nos debilitamos.
Replanteando el rol docente en la docencia universitaria de UCIMED.
Authors: Granados Fernando
Published: July 2019

Actualmente nos encontramos en un mundo donde los cambios a nivel científico y tecnológico son vertiginosos, lo cual nos conlleva a repensar los modelos de enseñanza-aprendizaje empleados en las instituciones educativas, incorporando las tecnologías de información y comunicación dentro de nuestro proceso educativo, esto implica un reto y una oportunidad, como lo menciona Peppino (2004) “cambiar el papel tradicional del docente y del alumno, generar materiales adecuados y, sobre todo, reflexionar acerca de las competencias indispensables para afrontar los cambios así como sobre las propias estructuras del sistema educativo superior
APRENDIZAJE EN EL ÁMBITO FARMACÉUTICO MEDIANTE SIMULACIÓN CLÍNICA
Authors: Calvo Maria
Published: July 2019

La educación farmacéutica permite a los futuros profesionales desempeñarse de manera efectiva según las expectativas del paciente en relación al cumplimiento de la calidad técnica y de la lex artis; sin embargo, desde hace muchos años a todo nivel se viene evidenciando la necesidad de formar a los estudiantes en el desarrollo de habilidades blandas, las cuales se entienden como aquellas competencias relacionadas con la comunicación y las relaciones, la motivación, el trabajo en equipo, la responsabilidad, la honestidad y el compromiso; así como, las actitudes pro-activas para resolver problemas y generar ideas innovadoras.
PATOLOGÍA DUAL
Authors: Oviedo Marín Luisa
Published: July 2019

Los estudios epidemiológicos internacionales y nacionales determinan que un 70% de estos pacientes con trastorno por uso de sustancias presentan de forma simultánea o secuencial otro trastorno mental, la patología dual (Szerman et al., 2012). Algunos autores consideran que se subestima esta realidad que podría abarcar al 100% de estos pacientes. Hay que tener en cuenta el caso del tabaco, que hasta hace poco tiempo no se consideraba entre los trastornos por uso de sustancias. La población general que sufre trastornos mentales presenta en más del 50% de los casos un trastorno por uso de sustancias cuando se incluye el tabaco, excluido en anteriores estudios (LevRan et al., 2013; Martínez Raga et al., 2013). Además, esta población tiene una elevada prevalencia al menos duplica la de la población general de otros trastornos médicos (metabólicos, infecciosos, neumológicos, neurológicos, oncológicos, etc.).
LA ESCUCHA TERAPÉUTICA
Authors: Piedra Matamoros Esteban , Saénz Garita Gustavo
Published: July 2019

Durante muchos años, los especialistas en neurociencias, lingüística y psicología han estudiado la relación entre el lenguaje y lo que nosotros como sujetos percibimos e interpretamos de la realidad. Una pregunta fundamental en esta línea es comprender el papel de las palabras y cómo calan en la elaboración subjetiva de la comprensión del mundo. Existe una clara diferencia entre nuestra realidad inmediata y la forma de utilizar los vocablos para interpretar y entender esa realidad. Cada sujeto, a partir de su propia subjetividad, genera sus patrones de conducta. Nuestra percepción de la realidad pasa por un filtro hecho por nuestras experiencias, la historia personal y vivencias de cada individuo. Parafraseando a Aristóteles en Concepción racionalista del lenguaje, citado en León Gómez (1983), las palabras habladas son los símbolos de la experiencia mental y las palabras escritas son los símbolos de las palabras habladas
Terapia genética
Authors: Lobo Chaves Marco Antonio
Published: July 2019

Para lograr el uso de este material genético hay que tener varios aspectos en mente. Primero, hay que definir cuál es la secuencia de ADN que se va a insertar al cuerpo del paciente. En estos casos depende mucho de la enfermedad que se está tratando de curar. Por ejemplo, en el caso de la Hemofilia tipo B, el gen que se ocupa es el que produce factor IX [3]. Segundo, una vez que el gen está bien identificado, se ocupa un vehículo para transportarlo a las células deseadas. Volviendo al ejemplo de Hemofilia, ocuparíamos un vector o vehículo, viral o no viral, para transportar el gen a las células hepáticas encargadas de la producción de factor IX. Cada una de estas dos categorías tiene sus pros y sus contras
MEDICIÓN DE LA FILTRACIÓN GLOMERULAR Y MÉTODOS CONVENCIONALES BASADOS
Authors: Carvajal Aria Francis
Published: July 2019

En un adulto joven la filtración glomerular es de aproximadamente 120-130 mL /min/1,73m2 de superficie corporal y declina progresivamente con la edad. 

Además, la medición de la FG es importante porque permite la detección temprana de pacientes con enfermedad renal, la aplicación de tratamientos tempranos, valorar la eficacia del tratamiento y ayuda a verificar cuando es necesaria la terapia de reemplazo renal entre otros.
¿Es posible comer rico en esta navidad y cuidar mi salud al mismo tiempo?
Authors: Castillo Karol
Published: July 2019

Es por esto que se requiere tomar nota de algunos consejos nutricionales que nos pueden ayudar a controlar esas kilocalorías en exceso y no iniciar el año nuevo con más kilogramos de peso. Una de las principales alternativas viables que tenemos en caso de que se preparen los alimentos en nuestros hogares, es analizar las preparaciones tanto en tipo y cantidad de ingredientes requeridos, así como en el método de cocción utilizado. Lo anterior es vital para lograr con pequeños cambios, reducción de calorías sin dejar de lado el sabor y la textura de los alimentos.
RESPIROMETRÍA DINÁMICA: SIMULACIÓN DE TRASTORNOS OBSTRUCTIVOS Y RESTRICTIVOS
Authors: Hung Chan Stephany
Published: July 2019

OBJETIVO: Evaluar la variación de los parámetros normales del flujo respiratorio en los estudiantes de Fisiología, carrera Medicina, Universidad de Ciencias Médicas, I semestre 2018 utilizando la Respirometría dinámica en condiciones obstructivas y restrictivas. 

MÉTODOS: 7 sujetos con una condición saludable, estudiantes del curso de Fisiología en Universidad de Ciencias Médicas durante el I semestre 2018. Fueron sometidos a tres pruebas respiratorias: en reposo, simulando condición obstructiva y simulando condición restrictiva durante un ciclo respiratorio. 

RESULTADOS: El análisis estadístico demostró que, para la mayoría de los parámetros respiratorios evaluados, no hubo un cambio diferencial significativo. Los parámetros FEV1, CVF, PIF, FEF25-75, e índice de Tiffeneau en los sujetos experimentales, no indicaron cambios al ser expuestos a diferentes condiciones simuladas tal como se esperaba. La medición del parámetro PEF, reflejó que, ocurrió una disminución de flujo al ser expuesto a las diferentes pruebas dinámicas.1 

CONCLUSIÓN: En el experimento se observó que para los parámetros evaluados con excepción de la variable PEF, no existe una diferencia al simular condiciones restrictivas y obstructivas con respecto a la condición de reposo.
MINUMAN JAHE HANGAT UNTUK MENGURANGI EMESIS GRAVIDARUM PADA IBU HAMIL DI PUSKESMAS NALUMSARI JEPARA
Authors: Wulandari Dyah Ayu , Kustriyanti Dwi , Aisyah Rofiatul
Published: July 2019

Emesis gravidarum merupakan mual muntah yang terjadi selama kehamilan. Mual terjadi pada pagi hari, tetapi ada yang timbul malam hari. Data di Jawa Tengah keluhan mual muntah pada ibu hamil mencapai 40-60% dari total kehamilan. Rasa mual pada awal kehamilan dapat dikurangi dengan menggunakan terapi komplementer antara lain dengan memberikan minuman jahe hangat. Pemberian minuman jahe efektif dalam mengatasi mual muntah ibu hamil trimester I. Keunggulan jahe adalah kandungan minyak atsiri yang mempunyai efek menyegarkan dan memblokir reflek muntah, sedang gingerol dapat melancarkan darah dan saraf bekerja dengan baik.. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian minuman jahe hangat terhadap emesis gravidarum pada ibu hamil trimester I di Puskesmas Nalumsari Jepara. Metode : Quasy Eksperiment dengan pendekatan Control Group Pre-Posttest Design. Populasi penelitian ini adalah ibu hamil di Puskesmas Nalumsari Jepara. Teknik pengambilan sampel menggunakan teknik Purposive Sampling sehingga besar sampel adalah 50 responden. Uji analisis data menggunakan uji Wilcoxon dan Mann Whitney. Hasil : Uji Mann Whitney mendapatkan nilai p 0.000. Kesimpulan : Terdapat pengaruh pemberian minuman jahe hangat terhadap emesis gravidarum pada ibu hamil trimester I di Puskesmas Nalumsari Jepara. Kata Kunci: jahe; emesis gravidarum
Reducción de poblaciones de Globodera pallida al cultivar avena después de papa.
Authors: Piedra Naranjo Ricardo , Avilés Chaves Jeannette
Published: July 2019

El objetivo de esta investigación fue estudiar el efecto del cultivo de avena (Avena sativa) sobre poblaciones del nematodo fitoparásito Globodera pallida que afecta el cultivo de papa (Solanum tuberosum) en la zona norte de la provincia de Cartago. El estudio se desarrolló de agosto del 2009 a marzo de 2010. Los escenarios estudiados consistieron en dos parcelas dedicadas al cultivo de papa: una se sembró con Avena sativa y la otra se mantuvo solamente con los residuos del cultivo anterior de papa. El área de cada parcela fue de1000 m2, y para el estudio se tomaron 20 submuestras de suelo por parcela. Después de homogeneizar se obtuvo una muestra compuesta de 200 gramos para un total de cinco muestreos en la investigación. En la investigación, para la extracción de quistes de suelo se utilizó el sistema de Fenwick modificado. Los resultados mostraron que la siembra de avena redujo las poblaciones de Globodera pallida que afectan el cultivo de papa, dado que en el último muestreo se encontraron 9,0 y 44,4 larvas y huevos viables por gramo de suelo para la parcela cultivada con avena y la parcela testigo respectivamente.
EVALUACIÓN DE DOS HÍBRIDOS DE TOMATE Cherry (Lycopersicum sculentum Mill.) BAJO AMBIENTE PROTEGIDO EN PURISCAL, COSTA RICA
Authors: Cordero Morales Carlos , Rojas Madrigal Jorge
Published: July 2019

Se evaluó en ambiente protegido la capacidad de producción de dos híbridos de tomate Cherry y lascualidades de los frutos con miras a comercializarlos en San Juan de Puriscal entre octubre del 2004 yabril del 2005. Se utilizó un invernadero de 210 m2

donde se sembraron 180 plantas de cada uno de loshíbridos Muscato y Natacha. El invernadero no contó con protección de malla antiáfidos. Se analizaronvariables de producción y las características de los frutos mediante pruebas de hipótesis de comparaciónentre medias. El rendimiento por planta del híbrido Natacha fue de 5,4 kg y el de Muscato de 3,9 kg conuna diferencia significativa (p≥0,01) entre ambas. Las diferencias de producción se pueden deber a queNatacha produjo más racimos por planta y a que sus frutos pesaron en promedio 15,04 g mientras que losdel híbrido Muscato alcanzaron solamente 11,95 g. La combinación de los dos factores pudieron causar lasdiferencias en la producción total, ya que ambos híbridos producen la misma cantidad de frutos por racimo.El mercado en Costa Rica exige frutas con pesos cercanos a 13 g de las dos variedades se ajustaronmás las frutas de Muscato, por su menor tamaño a los pesos y diámetros de fruta que se prefieren enel mercado. En el ensayo se utilizó poda dejando sólo un eje por planta; con este sistema las frutas delhíbrido Natacha sobrepasan los requerimientos del mercado en cuanto a tamaño, sin embargo su potencialde producción es muy alto por lo que se sugiere tratar de reducir el tamaño de sus frutas, para lo que esnecesario realizar nuevos estudios dejando dos o tres ejes por planta.
Balance de Nitrógeno en un sistema de producción de leche especializado
Authors: Montenegro Ballestero Johnny
Published: July 2019

El nitrógeno es un elemento que es asociado con el nivel productivo logrado en cualquier actividad agrícola; el sector lechero aplica grandes cantidades (hasta 500 kg de N ha-1 a-1) para estimular el crecimiento de los pastos y poder utilizar alta carga animal. Una cantidad importante del nitrógeno presente en el pasto consumido por las vacas en pastoreo es nuevamente retornado al suelo, y absorbidopor las raíces de los pastos. Esta condición se presenta en todas las pasturas, reciban o no fertilizante nitrogenado. Debido al alto costo de los fertilizantes nitrogenados se ha disminuido su aplicación, y dado que el reciclaje de este nutriente se convierte en la fuente más importante, se requiere conocer la magnitud del nitrógeno reciclado. Las vacas consumían 35 kg de verdura de desecho, 2,6 kg MS de concentrado por día, y 1,2 kg MS de pasto picado. Muestras de los alimentos proporcionados se analizaron en el laboratorio de piensos y forrajes del INTA para obtener los contenidos de nitrógeno. Con estos datos se calculó el nitrógeno total consumido diariamente por vaca. También se estimó la cantidad de heces y orina producidos; con base en la concentración de nitrógeno en ellos se calculó la cantidad de nitrógeno excretado. Adicionalmente se consideró el contenido de proteína en la leche producida.Palabras claves: reciclaje de nitrógeno, vacas Holstein, heces y orina.
Historical Inequality and Intergenerational Educational
Mobility: The Dynamics of Change in Rural Punjab
Authors: Cheema Ali , Farooq Naseer Muhammad
Published: July 2019

We analyze educational attainment over three generations in rural
Punjab, Pakistan, to determine if the fruits of post-independence development have
translated into comparable rates of educational and social opportunities for all
strata in the village economy. We show that the differences in class status
institutionalized at the time of colonial village settlement lead to a sustained
divergence in the rate of intergenerational educational mobility, with limited
mobility for nonproprietary and marginalized groups compared to proprietary
groups. Inter-class differences in the rate of mobility are higher in proprietary
landed estates where the colonial state had concentrated land rights and
governance in the hands of landowners compared to crown estates that had a more
egalitarian arrangement of land rights and governance. We find that the
divergence in inter-class mobility is worrying, so much so that the current
generation of marginalized households appears to have fallen a generation behind
in terms of educational attainment, even though it resides in the same villages as
the proprietary households.