bluuebunny/crossref_metadata_2025 huggingface dataset:
GSK3β/ITCH/c-FLIP Axis Counteracts TRAIL-induced Apoptosis in
Human Lung Adenocarcinoma Cells
Authors: Zheng Xiaofen , Huang Donglan , Liu Xiaohui , Liu Qiu-Yu , Gao Xuejuan , Liu Langxia
Published: January 2023

Aims:

Further investigation on the mechanism of action of tumor necrosis factor-related
apoptosis-inducing ligand (TRAIL) in NSCLC would shed light on the understanding of TRAIL
resistance and provide new clues for the counter-strategy.

Background:

Cellular FLICE-inhibitory protein (c-FLIP) is a critical inhibitor of TRAIL-induced
apoptosis. Our previous study suggested that glycogen synthase kinase 3β (GSK3β) positively
regulated c-FLIP expression in human lung adenocarcinoma cells. Meanwhile, other studies reported
that c-FLIP was degraded by HECT-type E3 ligase ITCH (Itchy E3 Ubiquitin Protein Ligase) via the
proteasome pathway.

Objective:

We will explore whether ITCH is involved in the expression regulation of c-FLIP
positively controlled by GSK3β during the treatment of TRAIL.

Methods:

Human lung adenocarcinoma cells were used to stably overexpress and knockdown GSK3β.
Quantitative real-time PCR (qRT-PCR) assay was used to test the expressional level of mRNA of
genes. Western blot analysis was employed to detect the expression of proteins at the protein level.
siRNA of ITCH was used to knock down its expression. TRAIL treatment was used to cause
apoptosis.

Results:

In the present study, we have confirmed the degradation of c-FLIP by ITCH protein and the
downregulation of ITCH expression by GSK3β in lung adenocarcinoma cells. Moreover, ITCH
silencing reversed the downregulation of c-FLIP protein caused by GSK3β-knockdown in the cells.
Accordingly, TRAIL-induced apoptosis facilitated by GSK3β knockdown was blocked by the
combined interference of ITCH.

Conclusion:

These results suggested that GSK3β/ITCH axis regulated the stability of c-FLIP and
influenced TRAIL-induced apoptosis. Taken together, our study revealed a GSK3β/ITCH/c-FLIP
axis, which counteracts TRAIL-induced apoptosis in human lung adenocarcinoma cells.
Benefits of GLP-1 Mimetics on Epicardial Adiposity
Authors: Yaribeygi Habib , Maleki Mina , Nasimi Fatemeh , Jamialahmadi Tannaz , Stanford Fatima C. , Sahebkar Amirhossein
Published: January 2023

The epicardial adipose tissue, which is referred to as fats surrounding the myocardium,
is an active organ able to induce cardiovascular problems in pathophysiologic
conditions through several pathways, such as inflammation, fibrosis, fat infiltration, and
electrophysiologic problems. So, control of its volume and thickness, especially in patients
with diabetes, is highly important. Incretin-based pharmacologic agents are newly
developed antidiabetics that could provide further cardiovascular benefits through control
and modulating epicardial adiposity. They can reduce cardiovascular risks by rapidly
reducing epicardial adipose tissues, improving cardiac efficiency. We are at the first
steps of a long way, but current evidence demonstrates the sum of possible mechanisms.
In this study, we evaluate epicardial adiposity in physiologic and pathologic states and
the impact of incretin-based drugs.
Changes of Colon in Rats with Different Ages in Response to
Lipopolysaccharide
Authors: Li Yanli , Guo Yuhui , Aoqi Liu , Ma Chengquan , Xiong Zhengguo , Yuan Ding , Zhang Changcheng , Zhang Jihong , Dun Yaoyan
Published: January 2023

Background:

Lipopolysaccharide (LPS) is an endotoxin that causes inflammation,
and the content of LPS increases gradually during the process of aging. Whether the
response of the colon to LPS stimulation will increase with age is yet unknown.

Objective:

The study investigated the effects of LPS stimulation on the colon of adult
and aging rats.

Methods:

43 healthy male SD rats were divided into 4 different groups: adult group and
LPS-stimulated adult group at the age of 4 months, and aging group and LPS-stimulated
aging group at the age of 22 months. Rats were stimulated by intraperitoneal injection of
LPS (1mg/kg) for 24 h. The morphological changes of the colon were observed, and intestinal
inflammatory response, tight junction proteins, apoptosis, and proliferation in intestinal
epithelial cells were detected.

Results:

A series of morphology changes occurred in the colon of adult rats after LPS stimulation,
the higher inflammatory response (TLR4, NF-κB, and IL-1β), changes in the
protein levels of tight junctions (ZO-1, Claudin1, and Claudin2), and increased apoptosis
(Bax, Bcl2) and proliferation (PCNA) of intestinal epithelial cells. The above changes
were also found in aging rats. LPS stimulation further promotes the above changes to
some extent in the colon of aging rats.

Conclusion:

A series of colon changes in rats was significantly damaged during LPS stimulation
and aging, and these changes were further aggravated to some extent in LPS-stimulated
aging rats.
The Chemistry of the Metabolites of Cyclophosphamide
Authors: Ludeman Susan M.
Published: January 2023

This is primarily an overview of the spontaneous (non-enzymatic l chemistry of the metabolites of cyclophosphamide, viz., cis- and trans-4- hydroxycyclophosphamide, aldophosphamide (and its hydrate), iminophosphamide. phosphoramide mustard, acrolein, and chloroethylaziridine. A brief description of detoxification products obtained through enzyme catalyzed reactions appears. Included
as the historical basis for the development of cyclophosphamide is the chemistry of ni trog n mustards. Among the topics covered are: perturbations to metabolite distributions and half-lives effected by buffer, structure, pH and nucleophiles; effects of pH on mechanism; alkylation versus P-N bond hydrolysis; the influence of nucleophiles on alkylation product distributions; the influence of substituents on alkylation rates; and preactivated forms of cyclophosphamide as metabolite precursors (4-hydroperoxycyclophos­ phamide and mafosfamide). A review with 66 references.
OXA-Type β-Lactamases
Authors: Naas Thierry , Nordmann Patrice
Published: January 2023

The OXA-type (oxacillin-hydrolysing) enzymes are widespread and have been mostly described in Enterobacteriaceae and in P. aeruginosa. They usually confer resistance to amino- and ureidopenicillin and possess high-level hydrolytic activity against cloxacillin, oxacillin, and methicillin. Their activities are weakly inhibited by clavulanic acid but sodium chloride (NaCl) possesses a strong il'lhibition
activity. Oxacillin-hydrolysing -lactamases belong to Ambler class D and thus possess an active serine site as classes A and C β-lactamases. Overall amino-acid identities between class D and class A or class C
β-lactamases is about 16%. Until now, 24 Ambler class D enzymes, named OXA-1 to OXA-22, AmpS and LCR-1, have been characterised, either by sequence and/or by biochemical analyses, but for none of them a three dimensional structure is yet available. While some oxacillinases present a significant degree of amino-acid identity (for example, OXA-l and OXA-4; OXA-10 (PSE-2) derivatives; OXA-2 and OXA- 3), most of them are only weakly related (20% to 30% amino-acid identity). Oxacillinases usually display a restricted-spectrum phenotype. However extension of their spectrum towards oxyimino cephalosporins and/or imipenem has recently been observed mostly as a consequence of point mutations in OXA-2 or OXA-10 derivatives. Their frequent plasmid- and/or integron-location provide them a mean for a wide diffusion.
Identification of Differentially Expressed Proteins in Rats with Early Subacute
Spinal Cord Injury using an iTRAQ-based Quantitative Analysis
Authors: Lou Yongfu , Lv Yigang , Li Zhen , Kang Yi , Hou Mengfan , Fu Zheng , Lu Lu , Liu Lu , Cai Zhiwei , Qi Zhangyang , Jian Huan , Shen Wenyuan , Li Xueying , Zhou Hengxing , Feng Shiqing
Published: January 2023

Background:

Injuries to the central nervous system (CNS), such as spinal cord injury
(SCI), may devastate families and society. Subacute SCI may majorly impact secondary damage
during the transitional period between the acute and subacute phases. A range of CNS illnesses has
been linked to changes in the level of protein expression. However, the importance of proteins during
the early subacute stage of SCI remains unknown. The role of proteins in the early subacute
phase of SCI has not been established yet.

Methods:

SCI-induced damage in rats was studied using isobaric tagging for relative and absolute
protein quantification (iTRAQ) to identify proteins that differed in expression 3 days after the injury,
as well as proteins that did not alter in expression. Differentially expressed proteins (DEPs)
were analyzed employing Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and
Genomes (KEGG) analysis to discover the biological processes, cell components, and molecular
functions of the proteins. We also performed Gene Set Enrichment Analysis (GSEA) software BP
pathway and KEGG analysis on all proteins to further identify their functions. In addition, the first
15 key nodes of a protein-protein interaction (PPI) system were found.

Results:

During the early subacute stage of SCI, we identified 176 DEPs in total between the control and damage groups, with 114 (64.77%) being up-regulated and 62 (35.23%) being down-regulated. As a result of this study, we discovered the most important cellular components and molecular activities, as well as biological processes and pathways, in the early subacute phase of SCI. The top 15 high-degree core nodes were Alb, Plg, F2, Serpina1, Fgg, Apoa1, Vim, Hpx, Apoe, Agt, Ambp, Pcna, Gc, F12， and Gfap.

Conclusion:

Our study could provide new views on regulating the pathogenesis of proteins in the
early subacute phase after SCI, which provides a theoretical basis for exploring more effective
therapeutic targets for SCI in the future.
Influence of Seashell on the Physical, Mechanical and Thermal Properties of Brick Mortar Mixtures
Authors: Essalem Mohamed Lemine Mohamed , Cherradi Toufik , Amziane Sofiane , Teguedy Mohamed Cheikh
Published: January 2023

Background:

In this work, the effect of crushed cockle shell (CCS) and mixed seashell (MS) as shell sand in cement hydraulic lime brick mortar was investigated. The seashells aggregates came from the shell middens of Mauritania.

Objective:

This study aims to valorize seashell waste in mortar brick mixes, to design a light insulating brick

Methods:

The seashells were heat treated at 105°C for 6h, then crushed and sieved into shell sand. Then, they were studied by X-ray diffraction (XRD), thermogravimetric analysis (TGA), and specific tests for mortar aggregates. Afterward, several mortar bricks were fabricated by replacing the natural sand with shell sand. The physical, mechanical, and thermal properties of the produced bricks were compared with two types of natural mortar bricks. In total Six types of masonry bricks were produced. The properties analyzed were the compressive strength, flexural strength, water absorption, bulk density and bulk porosity, thermal conductivity, and thermal resistance of the bricks.

Results:

It was observed that the use of seashell waste increased the porosity and water absorption of the bricks and decreased the bulk density and mechanical strength.

Conclusion:

It is concluded that the seashell shape promotes the porosity of the mortar bricks making them more insulating and lighter. The characterization of crushed cockle shells (CCS) and mixed seashell (MS) bricks helps to clarify the field and limits of application of these bricks.
Low Velocity Impact Response of Reinforced Concrete Flat Slabs
Authors: Abdulsahib Wael Shawky , Abduljabbar Marwah S. , Almuhsin Bayrak S.
Published: January 2023

Background

Dimensions of the reference concrete slab are 1950x1950x100 mm subjected to drop-weight impact loading.

Objective

A comprehensive parametric study was performed to examine the influence of many parameters on the RC slabs.

Method

From the viewpoint of cost and time savings, a three-dimensional finite element is a very good tool to predict the real behavior of the structural elements.

Result and Discussion

Results showed that the use of CFRP strips enhance the impact behavior of the slab. Contrarily, the existence of opening led to a dramatic decrease in the dynamic capacity of RC slabs with stress concentration around the openings. Furthermore, changing the shape of the impactor showed a significant effect on the peak impact load as well as the ultimate deflection at impact instant.

Conclusion

In the scope of this paper, the response of RC slab with top and bottom reinforcements exposed to drop-weight impact loading was inspected. Time histories of impact loads and deflections were presented in detail based on ABAQUS/ Explicit analysis. The findings presented in this paper can be presented as follows:

1. The FE models show a good correlation with the experimental data. Consequently, the proposed finite element models are efficient and economical tool to explorer the effect of many parameters on the performance of RC slabs subjected to drop-weight impact load.

2. The numerical simulation confirmed that using externally bonded CFRP strips has more influence on the peak deflection of the reinforced concrete slab than the recorded impact force.

3. Comparing to the flat shape of the impactor, the hemispherical and curved shape impactor can produce large penetration depth at the impact zone with higher plastic deformations in the concrete slab. However, the flat impactor produced higher deflection at the impact instant.

4. As the radius of the impactor increases, both the duration time and the peak impact force are increased. This is because of the higher contact area was obtained when the flat impactor (infinity radius of curvature) was used as compared to other impactors.

5. Due to decreases in RC slab stiffness, the presence of openings (regardless of their shape) has considerably increased deformations in concrete especially around perimeter of the openings extended to the nearby support.

6. It has been found that the eccentric impact loading causes higher plastic deformations than the concentric one.
Trans-sinus Implant using TTPHIL-ALL-TILT ®Technique as Alternative to Sinus Lifts: A Technical Description and Case Series
Authors: Nag P Venkat Ratna , Puppala Sarika , Roy Manisha
Published: January 2023

Background:

Severe atrophy of maxillary ridge and extended maxillary sinus pneumatisation limits the treatment options available for rehabilitating patients with teeth missing in posterior maxilla. Sinus lifts followed by bone grafting has become the norm for rehabilitating such patients. But, sinus lift procedures can be cumbersome, time-consuming and uneconomical, especially if patients are in need of immediate function.

Objective:

This case series describes a unique combination of placing trans- sinus implants using TTPHIL-ALL-TILT ® technique for treating patients with atrophied posterior maxilla.

Methods:

Three different clinical situations have been described where trans-sinus placement of implants using TTPHIL-ALL-TILT ® technique was done for managing atrophied posterior maxilla. first case was that of a single tooth missing in the posterior maxilla, the second of multiple posterior tooth missing (distal extension, partially edentulous condition) and the third being that of a completely edentulous maxilla. The implants were placed in a flapless tilted manner along with double bi-cortical engagement through the maxillary sinus.

Results and Discussion:

Following prosthetic rehabilitation, clinical reviews were performed after 6 months. In all cases, implant stability was manually checked and no pathological symptoms or signs were recovered at any follow-up visit.

Conclusion:

Trans-sinus implant using TTPHIL-ALL-TILT ® technique prove to be good choice to rehabilitate these three clinical scenarios. All three patients were extremely satisfied with the treatment outcome. This could very well become a convenient treat alternative to sinus lift procedures.
Unveiling the Potency of Phyto-Constituents to Target TNBC: Mechanism to Therapeutics
Authors: Usha Devi Aiswarya Sreekumar , V. Bava Smitha
Published: January 2023

The development of an effective therapeutic approach against TNBC is a formidable challenge at present. Efficacy and drug resistance issues in response to adjuvant and neoadjuvant chemotherapy have prompted the development of new therapeutic regimens. In this concern, the scientific community has started exploring natural sources including medicinal plants exhibiting anti-cancer activity for their potent inhibitory potential against TNBC. The comprehensive analysis underlying the molecular mechanism of action of these natural bio-compounds provided substantial evidence to subject a few of these for clinical application. This chapter highlighted the momentous phytoconstituents as a genetic or epigenetic modulator by inducing demethylation and histone deacetylation in TNBC. Bioactive phytoconstituents including berberine, luteolin, cantharidin, saikosaponin D, wogonoside, and others targeted cell proliferation, metastasis, angiogenesis, autophagy, and induced apoptosis in TNBC. Furthermore, combinational therapy comprising phytoconstituents and chemotherapeutic drugs was explored to improve the clinical outcome of the disease. Additionally, drug ability parameters including bioavailability and bio-absorption of these phytoconstituents were also discussed. 
Phyto-nanotechnology: Enhancing Plant Based Chemical Constituent Mediated Anticancer Therapies
Authors: Umar Zango Usman , Abubakar Aminu , Saxena Rohit , Arya Vedpriya
Published: January 2023

95% of anti-cancer agents were associated with the worst pharmaceutical
and pharmacokinetic properties including poor targeted cellular uptake, shorter halflife, toxicity, and many more. In this regard, nanotechnology including nanomedicines, nano-carriers, and nanomaterials may emerge as a beneficial tool to
facilitate an efficient delivery of therapeutic regimens by adapting active or passive
targeting mechanisms. The nanotechnology-based delivery system of phytoconstituents
can efficiently battle against recalcitrant TNBC. This chapter highlighted the
nanotechnology-based therapeutic approach including smart nanoparticles, cell
membrane-coated nanoparticles, and immunological cell-based nano-systems for the
treatment of TNBC. Furthermore, the role of nano-soldiers in improving bioavailability
and targeted drug delivery was highlighted. Nano conjugates of curcumin, anacardic
acid, EGCG, betulinic acid, gambogic acid, and resveratrol were also evaluated to
enhance the pharmacokinetic profile, distribution, and the release rate of respective
compounds and ultimately their ability to target TNBC. 
THE IMPORTANCE OF IMAGING IN RADIATION THERAPY: A REVIEW ARTICLE
Authors: Puspasari Aisya , Sulistyo Rafiq
Published: January 2023

Radiotherapy is one of the modern cancer treatment modalities. Advances in medical technology have revolutionized external radiotherapy with CT scanning, allowing for the visualization and grouping of tumors and at-risk organs in a three-dimensional view. However, CT has some limitations, especially in assessing the character and delineation of tumors. PET and MRI go beyond CT in terms of functional and anatomical images. PET/CT/MRI multimodality combines the strengths of each technique without conflating their respective weaknesses, thereby strengthening the role of imaging for radiation therapy management. On account of this, it can become the primary technique in radiotherapy modalities. This review aims to describe multimodality of the PET/CT/MRI process for radiotherapy and its potential clinical applications.
THE ROLE OF CHEST CT ANGIOGRAPHY AS A DIAGNOSTIC TOOL AND ROAD MAP FOR THE MANAGEMENT OF RASMUSSEN’S ANEURYSM: A CASE REPORT
Authors: Barkah Maskuril Barkah , Dini R. Erawati  , Aslam Ahmad Bayhaqi Nasir , Setyawan Agung , Tjakraatmadja Ricardo
Published: January 2023

Rasmussen’s aneurysm is a pulmonary artery pseudoaneurysm, secondary to the invasion of granular tissues to the pulmonary artery wall, causing massive hemoptysis. A 39-year-old male, with a history of pulmonary TB presented with massive hemoptysis, persistent cough, and dyspnea. Chest X-ray and Chest CT depicted active pulmonary tuberculosis and a co-infection with aspergillosis in the form of aspergilloma. Chest CT angiography (CTA) showed narrow-necked Rasmussen’s aneurysm with the feeding artery coming from the pulmonary artery of the apicoposterior segment and the systemic artery from the left thyrocervical trunk branch and left bronchial artery. Fluoroscopy-guided transarterial embolization with polyvinyl alcohol (PVA) and gel foam was performed from the left bronchial artery and thyrocervical trunk branch followed by transcatheter embolization with glue insertion via the pulmonary artery in the aneurysmal site. After the procedures the embolic agent completely filled the aneurysm and there were no complaints of hemoptysis during the follow-up. Appropriate chest CT angiography procedures can help diagnose Rasmussen’s aneurysm and become a road map for embolization. Transarterial catheter embolization from bronchial or non-bronchial systemic artery and pulmonary artery can be used as the treatment modality of choice for Rasmussen’s aneurysm in pulmonary tuberculosis with aspergillosis co-infection in the form of aspergilloma.
A REVIEW OF MONKEYPOX DISEASE AND FUTURE TREATMENT OPTIONS
Authors: SHUKLA AJAY KUMAR , MISRA SAURAV
Published: January 2023

The Monkeypox virus (MPXV) causative agent for Monkeypox disease resembles a smallpox-like illness and can lead to a number of serious medical issues in humans. It is an enveloped double-stranded DNA virus and belongs to the Orthopoxvirus genus. Monkeypox cases have increased after the smallpox vaccine was no longer administered. Monkeypox did not really receive widespread attention until the 2003 US outbreak. The majority of monkeypox cases connected to the 2022 outbreak are being reported in nations surrounding Europe and in the western world. The neurological, respiratory, and gastrointestinal systems are all known to be impacted. There are currently no standardised or ideal guidelines for the clinical management of patients with monkeypox (MPX), especially in low-resource settings. Patient outcomes may also be poor and their illnesses may last a long time. The range of clinical manifestations, including complications and sequelae, as well as characteristics of the illness that may be indicators of illness severity and poor outcomes, must be better understood in order to improve care. Though more research is required before they can be used in an endemic setting, new therapeutics and vaccines offer hope for the treatment and prevention of monkeypox.
DEVELOPMENT AND EVALUATION OF MICROSPONGE GEL OF AN ANTIFUNGAL DRUG
Authors: S. GUNASHEELA , CHANDRAKALA V. , SRINIVASAN S.
Published: January 2023

Objective: The objective of the present study was to compare the release effect of Luliconazole from different polymeric (Hydrophilic and Hydrophobic) microsponges prepared using varying concentrations. The best microsponge was selected and incorporated into different gel (Natural and synthetic) and drug release is determined and compared with marketed formulation. Methods: Polymers such as EC, HPMC, Eudragit RSPO and PVA as emulsifier, and solvent DCM is used as solvent. Microsponge were prepared by using the quasi emulsion solvent diffusion technique. FTIR was studied to estimate the incompatibility. Microsponges were evaluated for SEM, particle size, drug content, and In vitro diffusion studies. Optimized microsponge incorporated gel was prepared by using different gel (flax seed gel and Aerosil gel) were evaluated for pH, spreadability, extrudability, drug content and in vitro diffusion studies. Results: Theresults obtainedshowed no physical-chemical incompatibility between the drug and the polymers. EC, HPMC and EC combination was found to be a suitable polymer compared to Eudragit RSPO and other combination in preparation of microsponge. From the evaluation of microsponge, the optimized F1 formulations was incorporated into different gel (flax seeds, aerosil) and compared with marketed formulation in which MG-I (flax seed gel) was considered as good topical anti-fungal microsponge gel based on there physical parameters and drug release kinetics. Conclusion: Microsponge and microsponge gel were successfully prepared for Luliconazole and their evaluation studies of each dosage form revealed that topically applied microsponge gel possess immense potential to control the release rate of medicament to improve the bioavailability as well as patient compliance.
Effects of Computer-Based Test (CBT) and Paper and Pencil Test (PPT) on Academic Achievement and Test Anxiety of Secondary School Students’ in Economics
Authors: Abanobi C. C. , Agu Ngozi N. , Eleje Lydia I. , Metu Ifeoma C. , Mbelede Njideka G. , Ezeugo Nneka C.
Published: January 2023

Investigated in this study were the effects of Computer Based Test (CBT) and Paper and Pencil Tests (PPT) on Secondary School (SS) students’ academic achievement and test anxiety in Economics. The pretest-posttest non-randomized control group design was used as the research design. The study was done in Asaba, Delta State, Nigeria. All Senior Secondary II (SSII) students who offered Economics comprised the study’s population. 107 SS II students were selected as the sample. Two instruments - Economics Achievement Test (EAT) and Test Anxiety Inventory (TAI) were used for data collection. Both EAT and TAI were validated by the experts. The reliability coefficients of the instruments were .95 and .68, respectively. The data collected were analyzed using mean statistics to answer two research questions, whereas two formulated null hypotheses were tested at a .05 level of significance using ANCOVA. The findings of the study indicated that students’ mean achievement scores in PPT were slightly higher than students’ mean achievement scores in CBT and the students’ mean achievement scores were significantly different. Students in PPT exhibited greater test anxiety than their counterparts in CBT, even though the difference in the mean test anxiety scores of students in CBT and PPT was not significant. Based on the findings, the researchers recommended, among others, that the Federal Government should make and implement policies to mandate senior secondary students to use PPT for all internal assessments in various subjects in the country.
Elementos básicos de la Econometría
Authors:   Facultad de Estudios Superiores Aragón UNAM, Libreros Ángel Catalina Vanessa
Published: January 2023

Esta obra pretende distinguir los elementos matemáticos y las metodologías que conllevan los procesos cuantitativos estudiados por la Econometría a través de la cuantificación funcional e interpretación de parámetros, para la toma pertinente de decisiones en las teorías y realidades económicas donde se apliquen.
Biochemical and Molecular Evaluation of Rhizobium spp. and its Growth Promotion Studies with Lentil (Lens culinaris Medik. L.)
Authors: Banjare Umakant , Patel Arun Kumar , Pandey Ashish Kumar , Kumar Santosh , Singh Ramesh Kumar , Masurkar Prahlad , Singh Rakesh Kumar , Gupta Sandeep Kumar
Published: January 2023

Growth promoting Rhizobium spp are frequently used as biofertilizers for agricultural cropping system. Furthermore, Isolation, screening and biochemical characterization of Rhizobium for a specific plant is necessary to examine ability of isolated bacteria to affect the growth and development of host plant in various ways. The current study was aimed to isolate plant specific rhizobacterial strains which are compatible with lentil (Lens culinaris Medik.L.) plant. 20 bacterial isolates have been isolated from root nodules of lentil from various agro ecological area and their biochemical characterization was performed by different plant growth promotion activities. The result showed that, among 20 isolates, four isolates have vigorous plant growth promoting activities. Four bacterial strains were able to solubilise phosphorous along with hormone production. Moreover, among four bacterial strains, two strongly produced HCN and siderophore in vitro. Subsequently, all selected bacterial isolates were inoculated in lentil seeds of variety HUL57 to study germination percentage and vigour index of the crop. Out of four isolates 26N isolate performed best growth promotion activities on lentil seedlings. Finally, on the basis of performance of bacteria on plant, four isolates were characterized using molecular approach of species identification such as 16S rRNA sequencing.
Trabalho e práticas de cuidado obstétrico da enfermagem em maternidade pública
Authors: Belém Jameson Moreira , Pereira Emanuelly Vieira , Cruz Neto João , Silva Maria Rocineide Ferreira da , Quirino Glauberto da Silva
Published: January 2023

A forma como o trabalho e as práticas de cuidado são organizadas nas dinâmicas institucionais são determinantes para a qualificação da assistência obstétrica. O objetivo deste estudo foi descrever o trabalho e as práticas de cuidado ofertadas por profissionais de enfermagem em maternidade pública. Foi utilizada uma abordagem qualitativa, conduzida pelo referencial metodológico da etnoenfermagem, realizada com 12 informantes-chave em uma maternidade pública localizada na região do Cariri (CE). Adotou-se, para coleta de dados, o capacitador Observação-Participação-Reflexão, com registro das observações em diário de campo e uso de entrevistas individuais. Como resultado, emergiram temas culturais voltados para o trabalho na maternidade (“eu adoro trabalhar aqui, me sinto realizada”; “acho que tem um desgaste muito grande da equipe”; e “nem toda a equipe de enfermagem é engajada com a equipe médica”) e para as práticas de cuidado ofertadas (“a parte burocrática complica um pouco a parte da assistência”; “durante a assistência, os acadêmicos ajudam e os acompanhantes atrapalham”; e “a humanização deixa muito a desejar aqui na maternidade”). Concluiu-se que os sentidos atribuídos ao trabalho e às práticas de cuidado foram marcados pela (in)satisfação acerca de condições estruturais, relacionais, laborais, trabalhistas e ao modelo de gestão vinculado à entidade responsável por gerir a maternidade.
PROPOSALS ON REORIENTATION OF EXPORT SUPPLIES AND EXPANSION OF SALES MARKETS FOR ENTERPRISES OF THE ROSTOV REGION IN MODERN ECONOMIC CONDITIONS
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Татьяна Валентиновна Подольская , Дана Сергеевна Нижельская ,   Ростовский государственный экономический университет (РИНХ), Ростов-на-Дону, Россия
Published: January 2023

At the present stage, participants in foreign economic activity are faced with a few restrictions on export supplies caused by anti-Russian sanctions imposed by unfriendly states. Based on the conditions of the new economic and political agenda, the region needs to reorient export flows that were previously supplied to unfriendly countries and improve the mechanism for supporting exports to countries that are open to cooperation.
THE REFORMING OF THE SPHERE FOR HIGHER EDUCATION IN RUSSIA: GENESIS, FEATURES, AND IMPACT ON SOCIAL AND LABOR RELATIONS AT THE UNIVERSITY
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Елена Петровна Костенко , Анна Вячеславовна Гозалова ,   Южный федеральный университет, Ростов-на-Дону, Россия
Published: January 2023

The main stages, directions, and programs of reforming the sphere of higher education in Russia and their impact on changing the system of social and labor relations in universities are discussed in this article. The characteristic of the main categories of the institutions of higher education is given: the goals of creation, similarities and differences, the role of implementation programs of academic leadership. The authors have highlighted the features of social and labor relations in the organizations of higher education: in the sphere of attraction, employment, organization, and motivation of scientific and pedagogical workers.
PUBLIC-PRIVATE PARTNERSHIP IN REGIONS WITH LOW FINANCIAL STABILITY: PROBLEMS OF APPLICATION AND DIRECTIONS OF IMPROVEMENT
Authors:   Финансовый университет при Правительстве Российской Федерации, Москва, Россия, Павел Викторович Строев , Ольга Владимировна Пивоварова ,   Финансовый университет при Правительстве Российской Федерации, Москва, Россия
Published: January 2023

The article is devoted to the study of the peculiarities of the application of public-private partnership (PPP) mechanisms in regions with low financial stability. The group of constituent entities of the Russian Federation in various federal districts with relatively low rates of gross regional product and a fairly high share of gratuitous receipts in the revenue side of the budget is selected for the study: Republic of Mordovia, Republic of Tuva, Zabaykalsky Krai, Pskov Oblast, Oryol Oblast, Jewish Autonomous Oblast. The evaluation of the effectiveness of the use of PPP tools in this group of regions in comparison with other subjects of the Russian Federation is carried out, the current regulatory framework regulating PPP in them is analyzed, as a result of which the key problems inherent in such territories are identified. Based on the best regional practices, a set of measures and adjustments to the regulatory framework aimed at improving the efficiency of using the PPP mechanism in regions with low financial stability is proposed.
SUPPORT FOR SMALL AND MEDIUM-SIZED BUSINESSES IN ECUADOR AND RUSSIA: COMPARATIVE ANALYSIS
Authors:   Российский университет дружбы народов, Москва, Россия, Синди Габриэла Агирре Посо
Published: January 2023

This article presents the results of a study of support measures and state regulation of small business in Ecuador and the Russian Federation. The article provides a comparative analysis of the criteria for classifying economic entities as micro-enterprises, small and medium-sized companies, measures of state support for small businesses in these countries. The development of small business is the most important link in the economy of Russia and Ecuador; for this purpose, an effective system of its state regulation and support is needed. In Russia, in order to support small businesses, such tools as the issuance of preferential loans, the introduction of credit holidays, limits on commissions for acquiring, a moratorium on scheduled inspections, postponement of tax payments and reporting, reduction of admin-istrative burden, subsidies for starting a business, and new measures to support the information technology sector. In Ecuador, on the other hand, a set of laws and agencies has been developed to plan, execute and control public policies related to business development in general and for small and medium-sized organizations. The state has also developed special economic measures, including the creation of an entrepreneurship platform, a unified craft register, a unified register of small and medium-sized business entities, a national register of entrepreneurs, a portfolio of services for entrepreneurs and the Ecuador Entrepreneur virtual platform.
ANALYSIS OF THE EFFECTIVENESS OF THE USE OF INFORMATION AND POLITICAL TECHNOLOGIES AIMED AT IMPROVING THE LEGAL CULTURE OF VOTERS IN THE ROSTOV REGION
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Екатерина Александровна Попова , Елизавета Александровна Гринченко ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

The purpose of the research work is to study the objective conditions for the formation of information and political technologies in the electoral process to develop recommendations for improving the level of legal culture of voters in the Rostov region. The research of the Institute of Legal Culture allowed us to form a certain idea of the specifics of Russian statehood, revealing certain features of the Russian people in order to adapt the most acceptable information and political technologies to the electoral habitus.
ANALYSIS OF THE EFFECTIVENESS OF THE CURRENT SYSTEM OF SUPPORT FOR YOUNG PROFESSIONALS AND WORKING YOUTH IN THE ROSTOV REGION: PROBLEMS AND SOLUTIONS
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Светлана Алексеевна Литвинова , Анастасия Романовна Кротова ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

The paper provides an analysis of the causes of inactivity and lack of initiative of young professionals and working youth in the Rostov region. The activities of the Committee on youth policy in the field of support for young professionals and working youth in the Rostov region are considered. Proposals are put forward to improve measures to support young professionals and working youth, as well as the implementation of the dissemination of information about the events.
The Rise and Fall of High Literary Salons in the “Golden Age”
Authors:   Institute of Russian Literature (Pushkin House) of the Russian Academy of Sciences, Muravyova Оlga S.
Published: January 2023

The article is devoted to a brief history of a high literary salon in the first half of the 19th century. The article traces the reasons explaining its bright heyday and rapid decline. The salon is considered as a dual phenomenon, belonging simultaneously to literature and everyday life. Therefore, the article focuses on both the literary processes associated with salon culture and the customs and behavioral norms of the world. The fate of the literary salon seems to be a private, but very revealing plot in the history of the development of Russian society.
The Image of Bluebeard in the Age of Symbolism
Authors:   Russian State University for the Humanities, Pospelova Olga S.
Published: January 2023

The article examines the symbolics in the play “Ariana and Bluebeard, or Vain Deliverance” (1896) by the Belgian writer Maurice Maeterlinck and in the libretto “Duke Bluebeard’s Castle” by the Hungarian writer Béla Balazs (1911). There is a transformation of the Bluebeard story from folklore to the field of symbolist and neo-romantic literature, where it undergoes significant changes, being transformed into a “new age myth.”
“Podsnezhnik. Children and Youth Magazine” (St. Petersburg, 1858–1862). Table of Contents
Authors:   National Research University Higher School of Economics, Fateeva Maria S.
Published: January 2023

The paper provides a bibliographical description of the contents of “Podsnezhnik” magazine for children and young adults, published in St. Petersburg in 1858–1862 under the editorship of V.N. Maykov. Many well-known writers of the mid-19th century (I.A. Goncharov, D.V. Grigorovich, A.N. Maykov and others) participated in the publication. The introductory article briefly outlines the history of publication of “Podsnezhnik,” characterizes the materials that appeared in it and provides responses of contemporaries, as well as reviews the magazine’s place in the mid-19th-century literary process and its influence on subsequent children’s periodicals.
Property right under the Ottoman legal taxation system
Authors: Ahmeti Isuf , Lecaj Mentor
Published: January 2023

This paper aims to analyze the Ottoman taxation (timar) system which resembles medieval European feudalism. In this article, a chronological approach and contemporary scientific-methodological techniques have been used, as well as analytical and interpretation methods to clarify the Ottoman legal rules that regulate property rights focused in Kosovo. Based on this research, it has been found that the Ottoman government declared that all rural agricultural land belonged to the state, as well as that the peasant who worked on it had the status of an inherited tenant, and as a reward for his work he had the right to use it but as foreign property. This paper concludes that only a part of villagers representatives was integrated into the ranks of the spahis and the leaders of the Ottoman state, and Albanians had and kept such privileges until the end of foreign rule. This article is important to reflect on the influence that the Ottoman timar system had on the establishment of the Ottoman Empire in the countries which were its vassals, even though it has its own weaknesses (Kurmus & Yapucu, 2020).
Crown’s Intervention in the Self-Government of a Small Town. Choosing Burgomasters and Councillors in Sortavala in the Swedish Borderlands in the Late 17th and Early 18th Century
Authors: Katajala Kimmo
Published: January 2023

This chapter examines the selection of burgomasters and councillors in the small town of Sortavala. The purpose of investigating these processes is to use the typology in this volume to find out who had decisive control over the town.

Sortavala had been donated in the 1650s to Count Gustaf Adam Banér, who also appointed the town’s burgomasters. Count Banér never visited the town, but his affairs and manor were managed by a bailiff. Although not nominated as the burgomaster, these duties were carried out by the bailiff of the Count’s estate in the 1670s. There is no record of how the councillors were elected during that period. However, almost all of the councillors were local eastern Finns or of Karelian peasant origin. In this era, Sortavala can be characterised as having resembled, at least in part, the category of a noble town.

The largest fiefdoms were reduced in 1680. Between 1681 and 1685, the Sortavala burghers paid their taxes to the Crown. During this period, they were actively involved in the selection of councillors. Johan Mether, who had managed the manor and estate, first for the Count and then for the Crown, and from 1685 as a tax-farmer, held the position of burgomaster. In the early 1690s, when Mether’s son-in-law, Carl Ottoson, was appointed vice burgomaster, the Mether family ruled the town so that it assumed the features of a privatised monopoly town. The influence of the manor increased even further when Salomon Enberg, who was also appointed burgomaster by the governor general, became the new tax-farmer of the manor. Under Enberg, the role of the town’s burghers in the election of the burgomaster and the councillors seems to have completely vanished.

After Enberg, the governor general appointed Benjamin Krook as burgomaster. There is no information on how new councillors were selected during his time. However, the names and backgrounds of the new councillors suggest that education or social status was now an important selection criterion. Under Benjamin Krook, the link between the manor and the burgomaster’s post seems to have been broken, so that in the last decade before being destroyed in the war in 1710, Sortavala ranks quite clearly in the state-led town category in urban typology.
Kin group and noble dynasty: A campaign between elite families in Jakobstad, Ostrobothnia
Authors: Miettinen Tiina
Published: January 2023

The story of Jakobstad and its changing power structure is also a story of the shades of feudalism and the landlords who tried to procure more influence in this Finnish town. The town of Jakobstad is located in Ostrobothnia, Finland, on the shores of the Gulf of Bothnia, part of the Baltic Sea. It was established in 1652 by Countess Ebba Brahe. I examine the town’s two leading men and their families. The first, Henrik Tawast, was a bailiff of Countess Ebba Brahe's donated land. The other was Rasmus Påhlsson, a peasant freeholder and merchant. They tried to create their own kind of strong family dynasties, which also held leading positions in the town administration and trading business. Granted donations were problematic in terms of peasant freeholders’ rights and independence. In theory, the power in towns should have been in the hands of the town council. The situation in Jakobstad was exceptional because it had been established on donation land. The town burghers and the town council in Jakobstad were not as independent as in other towns: they were subordinate to the donation administration. The power and supremacy in Jakobstad lay in the hands of Ebba Brahe, and she assigned the rights to her donation bailiff, Henrik Tawast. This patron-client relationship between Ebba Brahe and Tawast families is a key factor to understanding Jakobstad's confused administration in the 17th century. The town council was divided into two opposing forces: the Tawast family dynasty and Rasmus Påhlsson’s large family network. Both struggled for pre-eminence in Jakobstad at the end of 17th century. After the Great Reduction of 1680, the Tawast family lost its power in Jakobstad, but its members found their way into high-ranking positions in both the military and the civil service.
New Femto Plus Method to Cure Patients Diagnosed with Astigmatism
Authors: AA Zilfyan
Published: January 2023

Today, Femto Lasik surgery is considered to be one of the most common among all keratorefractive surgeries. Despite the significant success of refractive surgery, patients have complains of an asthenopic nature after surpassing the procedure of laser vision correction. Purpose: The main purpose of this work was to study the speed of rehabilitation of visual functions after Femto Lasik surgery among patients with astigmatism after a six-day course of Femto Plus apparatus treatment. Methodology: We have created 2 groups in order to conduct the analysis. Each group included 60patients (120eyes). All participants were diagnosed with astigmatism before the surgery. Patients included in the second group went to the six-day course of the Femto Plus apparatus treatment on the second day after the surgery. Results: The visual indicators in patients of the first group after Femto Lasik increased by 34%. Among the patients of the second group, visual indicators (uncorrected visual acuity) after the Femto Lasik surgery with the application of Femto Plus method increased by 60.7%. Conclusion: The new Femto Plus method allows restoring visual functions quickly and effectively after Femto Lasik surgery among patients with astigmatism.
Design and Development of Management Information Systems at the University of Lampung Library Repository Using the Laravel Framework.
Authors: Sahid Anwar , Nama Gigih Forda
Published: January 2023

The University of Lampung has a library that is used to support the university's academic activities. One of the services at the Unila library is a digital library service that is used to upload scientific works into the repository, but there are still manual processes that are carried out repeatedly such as collecting requirements files, giving accounts and coordinating with students who require to come to the library continuously. so that the process carried out is not efficient. This study aims to build a management information system on the repository using the Laravel framework which can be used as a solution for the Unila library to make it easier for users to upload scientific works into the digital library repository. The development of this application uses the kanban method, which includes the process of analyzing system requirements, designing, developing to testing. The results of this study succeeded in providing a file upload service for account application requirements and uploading a repository link that was validated by the admin. The service is then tested using the blackbox method which produces the expected output so that it can be concluded that the application passes the test.