bluuebunny/crossref_metadata_2025 huggingface dataset:
O programa Mulheres Mil como política pública de educação profissional: levantamento e descritores das produções acadêmicas em nível stricto sensu (2013-2021)
Authors: Azevedo Marcio Adriano de , Duarte Tathyane Torres da Silva , Araújo Sandyeva Francione Silva
Published: September 2022

The article aims to collect the academic production about the Mulheres Mil Program, based on scientific academic productions at the stricto sensu level, as part of ongoing qualitative research by the Graduate Program in Professional Education of the Federal Institute of Education, Science and Technology of Rio Grande do Norte, following the theoretical-methodological procedures of bibliographic and documentary analysis, based on the CAPES’ Database of Theses and Dissertations (2019-2021). As a professional education public policy, the Program was initially conceived and implemented as a pilot project in thirteen states in the North and Northeast regions of Brazil, through an agreement established with Canada, starting in 2007. Initially, the objective would be promoting professional and technical qualification for 1,000 women from the North and Northeast regions of the country, until the year 2010. In 2011, a MEC Ordinance institutionalized the Program at a national level, aiming to qualify 100,000 women in social vulnerability, until 2014. The partial results show that research on the Mulheres Mil is still incipient to indicate the results of its implementation and the achievement of the objectives regarding the original design.
A mini review of machine learning in inorganic phosphors
Authors: Jiang Lipeng , Jiang Xue , Lv Guocai , Su Yanjing
Published: September 2022

Machine learning has promoted the rapid development of materials science. In this review, we provide an overview of recent advances in machine learning for inorganic phosphors. We take two aspects of material properties prediction and optimization based on iterative experiments as entry points to outline the applications of machine learning for inorganic phosphors in terms of Debye temperature prediction and luminescence intensity and thermal stability optimization. By analyzing the machine learning methods and their application objectives, current problems are summarized and suggestions for subsequent development are proposed.
Proposed Method of Combining Continuum Mechanics With Einstein Field Equations
Authors: Ogonowski Piotr
Published: September 2022

The article proposes an amendment to the relativistic continuum mechanics which introduce the relationship between density tensors and the curvature of spacetime. The resulting formulation of a symmetric stress-energy tensor for a system with an electromagnetic field, leads to the solution of Einstein Field Equations indicating a relationship between the electromagnetic field tensor and the metric tensor. In this EFE solution, the cosmological constant is related to the invariant of the electromagnetic field tensor, and an additional gravitational pull appears, dependent on the velocity of orbiting bodies and the vacuum energy contained in the system. In flat Minkowski spacetime, the vanishing four-divergence of this stress-energy tensor expresses relativistic Cauchy's momentum equation, leading to the emergence of force densities which can be developed and parameterized to obtain known interactions. Transformation equations were also obtained between spacetime with fields and forces, and a curved spacetime reproducing the motion resulting from the fields under consideration, which allows for the extension of the solution with new fields.
Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis
Authors: Schirò Giuseppe , Di Stefano Vincenzo , Brighina Filippo , Iacono Salvatore , Monastero Roberto , Balistreri Carmela Rita
Published: September 2022

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease, characterized by progressive degeneration of upper and lower motor neurons in the cortex and spinal cord. Although the pathogenesis of ALS remains unclear, evidence on the role of the clonotypic immune system is growing. Adaptive immunity cells often appear changed in number or activation profile peripherally and centrally. However, their role in ALS appears conflicting. Data, from human and animal model studies, currently reported in literature show that each subset of lymphocytes and their mediators may mediate a protective or toxic mechanism in ALS, affecting both its progression and risk of death. In the present review article and attempt is made to shed light on the actual role of the cellular clonotypic immunity in ALS by integrating recent clinical studies and experimental observations.
Deskripsi Korban Mati Kecelakaan Lalu Lintas yang Dikirim ke RSUD Dr. Moewardi Tahun 2016 - 2020 (Berdasarkan Ciri-Ciri Luka)
Authors: Annisa Salsabila  , Wujoso Hari , Suwandono Adji
Published: September 2022

Pendahuluan: Setiap tahun, angka terjadinya kecelakaan lalu lintas selalu mengalami peningkatan seiring dengan peningkatan tingkat mobilisasi. Penelitian ini bertujuan untuk mengetahui ciri-ciri luka pada korban mati akibat kecelakaan lalu lintas yang ditangani Instalasi Forensik RSUD Dr. Moewardi Surakarta.

Metode: Penelitian ini menggunakan metode deskriptif observasional dari data Visum et Repertum di RSUD Dr. Moewardi Surakarta. Teknik sampling pada penelitian ini adalah total sampling yaitu seluruh Visum et Repertum sejak Januari 2016  - Desember 2020.

Hasil: Dari data Visum et Repertum pada tahun 2016 – 2020 didapatkan sebanyak 99 kasus forensik patologi kecelakaan lalu lintas dengan ciri-ciri luka sebagai berikut: (1) Lokasi luka yang paling banyak ditemukan yaitu di kepala dan ekstremitas bawah dengan jumlah yang sama masing-masing sebanyak 89,89%; (2) Jenis luka yang paling sering ditemukan adalah jenis luka terbuka sebanyak 94,94%; (3) Dasar luka paling banyak yaitu dasar luka tulang sebanyak 43,43%; (4) Tepi luka rata didapatkan sebanyak 6,06% dan tepi luka tidak rata sebanyak 14,14%; (5) Adanya patah tulang didapatkan sebanyak 41,41%.

Kesimpulan: Lokasi luka paling banyak terdapat di kepala dan ekstremitas bawah, jenis luka yang paling sering ditemukan adalah luka terbuka, dasar luka paling banyak adalah dasar luka tulang, tepi luka paling banyak adalah tepi luka tidak rata, dan lebih banyak kasus yang tidak terdapat adanya penjelasan mengenai patah tulang.
Serbest Ticaret Anlaşmalarının Türkiye’nin Dış Ticaretine Etkileri: Çekim Modeli İle Bir İnceleme
Authors: AYRAN CİHAN Kezban , SANDALCILAR Ali Rıza
Published: September 2022

Bu çalışmada Türkiye’nin yapmış olduğu Serbest Ticaret Anlaşmalarının (STA) dış ticaret üzerine etkileri araştırılmıştır. Bu amaçla STA’ların ihracat ve ithalat üzerine olan etkileri ürün grupları bazında incelenmiştir. 1991-2019 dönemi için Türkiye’nin STA yapmış olduğu ülkeler içinde ticarette payı en fazla olan 12 ülke çalışmaya dahil edilmiştir. Çalışmada uluslararası ticari akımları açıklamak üzere kullanılan yöntemlerden biri olan çekim modeli kullanılmıştır. Elde edilen sonuçlar STA’ların ürün grupları bazında ele alınan ticaret üzerinde anlamlı bir etkiye sahip olduğunu göstermiştir. Diğer taraftan ülkeler arasındaki uzaklığın ticareti azaltıcı bir faktör olarak yer aldığı belirlenmiştir. Ayrıca tahmin edilen modeller sonucunda Türkiye’nin dış ticaretinde çekim modelinin geçerli olduğu ortaya konmuştur
A vector method for finding sequences in big data
Authors: Khakhanova Hanna
Published: September 2022

A technological software solution is proposed for metric search and identification of logical-temporal patterns of a business data flow by creating additional vector data structures and a parallel method for their processing. The subject of research is the methods of searching and identifying logical-temporal patterns in big data. The purpose of the study is to increase the efficiency of searching and recognizing logical-temporal patterns that semantically form business functionality in an 8-hour frame of screenshots with "garbage" data. Applied methods: apparatus of set theory and Boolean algebra, metric models for determining parameters for sets of binary vectors, elements of probability theory, theory of algorithms, software modeling. The results obtained: a method for searching and recognizing patterns based on a vector problem of character sequences that identify patterns in big data streams using unitary coding of information primitives and data; vector models are unitary-encoded data structures for describing a big data flow as Cartesian products of a set of primitive-string-markers and a discrete sequence of implementation of a given time frame. The practical significance of the work: the implementation of the vector method, which made it possible to create a pattern recognition program in a big data stream with a probability of 0.77%.
Implementation of The ID3 Decision Tree Algorithm Method For Clothing Recommendations
Authors: Hayati Nur , Susilo Purnomo Hadi , Hanifah Ayu Ismi Hanifah
Published: September 2022

Peran teknologi dalam persaingan dunia bisnis sangatlah berpengaruh, maka dari itu pelaku bisnis untuk senantiasa mengembangkan bisnis dengan memanfaatkan teknologi yang ada sekarang. Inovasi-inovasi baru sangatlah dibutuhkan dalam hal berbisnis seperti peningkatan kualitas produk, dan mengetahui permintaan pasar karena dunia bisnis hari ke hari mengalami kemajuan yang sangat signifikan. peran besar teknologi dalam bidang penjualan dengan sifat manusia yang konsumtif. Teknologi untuk mempermudah dalam hal berbisnis dan juga mempermudah banyak hal, yang penting dalam teknologi untuk mempermudah seorang pembisnis dalam menjalankan bisnisnya. Oleh karena itu dengan metode ID3 decision tree ini digunakan untuk mempermudah pelanggan atau pengguna untuk memilih baju yang sesuai dengan karakter dirinya. Metode pengambilan data yang digunakan yaitu dengan pengumpulan wawancara secara online atau bisa disebut dengan kuisioner dengan 50 responden 30 untuk data training sebagai acuhan  dan 20 untuk data testing dengan beberapa atribut yang digunakan, dan sistem ini menggunakan program web php dan database  mysql. Hasil dati sistem rekomendasi ini mendapat keakurasian sebesar 85% dari 20 data test.
A Multi-level Weighted Concept Drift Detection Method
Authors: Han meng , Chen zhiqiang , WU Hongxin , Li muhang , Zhang xilong
Published: September 2022

The concept drift detection method is an online learner. Its main task is to determine the position of drifts in the data stream, so as to reset the classifier after detecting the drift to improve the learning performance, which is very important in practical applications such as user interest prediction or financial transaction fraud detection. A new level transition threshold parameter is proposed, and a piecewise weighting mechanism including "Stable Level-Warning Level-Drift Level" is innovatively introduced in concept drift detection. The instances in the window are weighted in levels, and it is applied to the double sliding window. Based on this, a multi-level weighted drift detection method(MWDDM) is proposed. Especially, two variants which are MWDDM_H and MWDDM_M are proposed basd on Hoeffding inequality and Mcdiarmid inequality respectively. Experiments on artificial datasets show that MWDDM can detect abrupt and gradual concept drift faster than any other comparison algorithms, while maintaining a low false positive ratio and false alarm rate. Experiments on real-world datasets show that MWDDM has the highest classification accuracy in most cases.
A new neural network approach for solving variable-order fractional time-varying delay differential equations
Authors: Lasaki farahnaz Golpour , ebrahimi hamideh , Ilie mousa
Published: September 2022

In this paper, a new functional link neural network based on Lagrange polynomials is introduced. Due to the well-known efficiency of Lagrange polynomials for solving different problems in fractional calculus, these functions are considered as the neuro-solutions for a class of nonlinear variable-order fractional time-varying delay differential equations. Compared with the other kinds of neural networks such as multilayer perceptron, the suggested functional link neural network shows more satisfactory results. Since the order value of derivative and delay are not constant, it is crucial to choose an appropriate activation function for solving these problems. Then, the effect of some common important activation functions on the numerical simulations is studied. The results for several examples are examined that confirm the performance of the proposed functional neural network.
Surgical anatomy of the lingual lymph nodes. Systematic literature analysis and proposition for topographic classification.
Authors: Gvetadze Shalva , Mudunov Ali , Roshchina Ekaterina , Solodkiy Vladimir , Nudnov Nikolay , Chkhikvadze Vladimir , Ilkaev Konstantin , Lv Mingming , Yang Xin , Sokorutov Vasiliy , Sun Jian
Published: September 2022

Purpose:Metastatic involvement of the lingual lymph nodes (LLNs) in oral cavity squamous cell cancer has recently been proven to significantly reduce locoregional control and survival. Despite recent refinements in the detection of these lesions, the understanding of the LLN topographic anatomy among clinicians is limited. A proposition of a topographic division on LLN based on a comprehensive literature search and synthesis may be helpful in this condition.
Methods:A literature search and election based on contemporary PRISMA guidelines was performed for sources on LLN anatomy with special attention on their subdivision.
Results:Four topographic LLN subgroups were defined: median – between genioglossal and geniohyoid muscles; intermediate para-hyoid – medial to the hyoglossal muscle, at the greater cornu of the hyoid bone; lateral sublingual (paraglandular) LLNs – at the sublingual salivary gland; lateral submandibular (paraglandular) LLNs –lateral to the hyoglossal muscle, at the deep surface of the submandibular salivary gland.
Conclusion: The development and implementation of a unified anatomical topographic classification of LLN subgroups may be among the important conditions for improving the detection and treatment of LLN lesions.
Predictors of Complex PTSD: The Role of Trauma Characteristics, Dissociation, and Comorbid Psychopathology
Authors: Torres Estefani Guzman , Krause-Utz Annegret , Sack Martin
Published: September 2022

Background
Complex Posttraumatic Stress Disorder (CPTSD) has previously been associated with earlier trauma onset, repeated interpersonal traumatization, more dissociation and more comorbid psychopathology. However, it is still debated if the afore-mentioned risk factors are related to CPTSD diagnosis or rather indicative of a more severe form of post-traumatic distress. The aim of this study was to compare patients with a CPTSD diagnosis to those with PTSD in trauma characteristics (onset, chronicity, interpersonal nature), dissociation, and psychiatric comorbidities, while accounting for symptom severity.
Methods
In total, N = 81 patients with a trauma history (n = 43 with CPTSD; n = 37 with PTSD) underwent diagnostic interviews by trained clinicians and completed measures on CPTSD symptom severity, trauma characteristics, and dissociation (Screening for Complex PTSD; Dissociative Experience Scale Taxon).
Results
Patients with CPTSD reported earlier onset of trauma, more trauma perpetrated by acquaintances or family members, and more comorbidities than those with PTSD, also when accounting for symptom severity. No group differences in chronicity and dissociation were found. Severity of CPTSD was associated with more comorbid (affective) disorders and dissociation in both diagnostic groups.
Conclusion
Findings largely confirm earlier research, suggesting that CPTSD is associated with traumatic events that start earlier in life and are perpetrated by family members or acquaintances. Focusing on transdiagnostic symptoms, such as dissociation, may help to detain symptom deterioration. Further research is needed to replicate findings in larger samples and to elucidate possible working mechanisms, such as emotion dysregulation or negative self-image.
Large spin-orbit torque generated by amorphous iron silicide
Authors: Hsu Cheng-Hsiang , Karel Julie , Roschewsky Niklas , Kleidermacher Hannah , Sayed Shehrin , Cheema Suraj , Bouma Dinah , Hellman Frances , Salahuddin Sayeef
Published: September 2022

Spin-orbit torque (SOT) shows great potential for next-generation memory technology. Conventionally, the underlying physics of SOT has been associated with heavy (high-Z) elements and/or intrinsic bandstructure. Here, we report large spin-orbit torques in amorphous iron silicides, a material that involves only light elements and for which an E-k relationship cannot be defined. We have achieved a spin-orbit torque efficiency as high as 2.0 (i.e. 200%), which is comparable to the highest known spin-orbit torque efficiency material system (topological insulator). We also found that the SOT efficiency shows a functional dependence on the relative position of the Fermi level with respect to the density of states, indicating an intrinsic origin. In addition, the SOT efficiency does not follow the decreasing trend with increasing conductivity as is typically found in conventional materials. The conventional trend makes it difficult to alter the product of SOT efficiency and conductivity, thereby limiting the overall efficiency of a SOT device. Our results demonstrate a new class of material system, amorphous silicides, where it is possible to generate strong spin currents and where the underlying physics of spin current generation is very different, allowing to circumvent some of the fundamental limitations of conventional materials.
Association between noise-induced hearing loss in the petrochemical workers and co-exposure to toluene, ethylbenzene, xylene, and styrene: a cross-section survey in southern China
Authors: Zhang Yan , Liu Yan , Ji Penglei , Liu Xin , Chen Qingfei , Qin Jingyao , Liao Qilong , Du Rui , Deng Qifei , Xiao Yongmei , Xing Xiumei
Published: September 2022

Exposure to noise and high concentrations of organic solvents such as toluene, ethylbenzene, xylene, and styrene (TEXS) can cause hearing loss. However, there is limited information on the association between noise-induced hearing loss and low-level TEXS exposure. In this study, we conducted a cross-sectional survey, measuring pure-tone audiometry of 1496 petrochemical workers exposed to noise in South China from Octo to Dece 2020. Individual cumulative noise exposure (CNE) levels and benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) exposure were assessed, and the average CNE was 93.27 ± 4.92 dB(A)·years. The concentrations of BTEXS were considered as low-level due to they were far below the occupational exposure limits. Participats exposed to BTEXS were 569, 524, 156, 452, and 172 respectively. After adjusting for covariates such as smoking status, drinking status, BMI, using ear protection and personal protective equipment, earphone/headphone type and volume, and duration of use, all logistic regression model analyses showed that CNE was consistently positively associated with hearing loss (HL) and high-frequency hearing loss (HFHL). Compared with participants in the lowest quartile of CNE, participants in the highest quartile showed an OR of 5.229 (95% CI: 3.179, 8.598) for HFHL. TEXS exposure was significantly positively associated with HL (OR 1.679, 95%CI 1.086, 2.597), SFHL (OR 2.440, 95%CI 1.255, 4.744) and HFHL (OR 1.475, 95% CI 1.077, 2.020) in the two-pollutant models. And more, no interaction between CNE and TEXS exposure and their effects on HL and HFHL was observed. In conclusion, in the case of noise exposure, low-level TEXS exposure can still impair hearing function, mainly manifested as speech-frequency hearing loss. Co-exposure to noise and TEXS would cause more severe damage on hearing function than exposure to noise or TEXS alone. Therefore, TEXS-exposure workers should be included in hearing protection programs.
Analysis of the Cytotoxic and Genotoxic Effects in a Population Chronically Exposed to Coal-Mining Residues
Authors: León-Mejía Grethel , Rueda Robinson Alvarez , Perez Jose , MIRANDA-GUEVARA ALVARO , moreno Ornella Fiorillo , Quintana-Sosa MILTON , TRINDADE Cristiano , De moya Yurina , Ruiz Martha , Bello Yesit , Luna Ibeth , Oliveros Ludis , Acosta-Hoyos Antonio , Pacheco Leonardo , Olívero-Verbel Jesús , SILVA JULIANA DA , henriques JOAO pegas
Published: September 2022

During coal-mining activities, many compounds are released into the environment that can negatively impact human health. Particulate matter, polycyclic aromatic hydrocarbons (PAHs), metals, and oxides are part of the complex mixture that can affect nearby populations. Therefore, this study was designed to evaluate the potential cytotoxic and genotoxic effects of coal residues on peripheral blood lymphocytes and buccal cells in individuals chronically exposed to them. We recruited 150 individuals who lived more than 20 years in the Loma-Colombia and 120 control individuals from the city of Barranquilla without a history of exposure to coal-mining. In cytokinesis-block micronucleus cytome (CBMN-Cyt) assay, significant differences in the frequency of micronucleus (MN), nucleoplasmic bridge (NPB), nuclear bud (NBUD), and apoptotic cells (APOP) were observed between the two groups. In buccal micronucleus cytome (BM-Cyt) assay, a significant formation of NBUD, karyorrhexis (KRX), karyolysis (KRL), condensed chromatin (CC), and binucleated (BN) cells was observed in the exposed group. Considering sociodemographic factors, a significant correlation was found between CBMN-Cyt-NBUD and vitamin consumption and between CBMN-Cyt-MN and CBMN-Cyt-APOP and meat consumption. Moreover, a significant correlation was found between BM-Cyt-KRL and vitamin consumption. Using Raman spectroscopy, a significant increase in the concentration of DNA/RNA bases, creatinine, polysaccharides and fatty acids was detected in the urine of individuals exposed to coal-mining compared to the control group. These results contribute to the discussion on the effects of coal-mining on nearby populations and the development of diseases due to chronic exposure to these residues.
Association of Prior COVID-19 Infection With Newly Diagnosed Erectile Dysfunction: Evaluation of 42,406 COVID-19 Recovered Men
Authors: Hebert Kevin , Matta Rano , Horns Joshua , Paudel Niraj , Das Rupam , McCormick Benjamin , Myers Jeremy , Hotaling James
Published: September 2022

We sought to assess if COVID-19 infection recovery is associated with increased rates of newly diagnosed erectile dysfuncton(ED). Using IBM MarketScan, a commercial claims database, men with prior COVID-19 infection were identified using ICD-10 diagnosis codes. Using this cohort along with an age-matched cohort of men without prior COVID-19 infection, we assessed the incidence of newly diagnosed erectile dysfuncton(ED). Covariates were assessed using a multivariable model to determine association of prior COIVD-19 infection with newly diagnosed ED. 42 406 men experienced a COVID-19 infection between January 2020 and January 2021 of which 610 (1.46%) developed new onset ED within 6.5 months follow up. On multivariable analysis while controlling for diabetes, cardiovascular disease, smoking, obesity, hypogonadism, thromboembolism, and GU malignancy, prior COVID-19 infection was associated with increased risk of new onset ED (HR 1.27; 95% CI 1.1-1.5; P=0.002). Prior to the widespread implementation of the COVID-19 vaccine, the incidence of newly diagnosed ED is higher in men with prior COVID-19 infection compared to age-matched controls. Prior COVID-19 infection was associated with a 27% increased likelihood of developing new-onset ED when compared to those without prior infection.
Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves
Authors: Gu Dongsheng , Soepriatna Arvin H , zhang Wenjun , Li Jun , Zhao jenny , Zhang xiaoli , Shu xianhong , Wang yongshi , Landis Benjamin J , Goergen Craig J , Xie jingwu
Published: September 2022

Background
Fibrosis is a pathological wound healing process characterized by excessive extracellular matrix deposition, which interferes with normal organ function and contributes to ~ 45% of human mortality. Fibrosis develops in response to chronic injury in nearly all organs, but the mechanism by which chronic damage in epithelial cells triggers a cascade of events leading to fibrosis remains unclear. While hedgehog (Hh) signaling activation has been associated with fibrosis in the lung, kidney, and skin, it is unknown whether hedgehog signaling activation is the cause or the consequence of fibrosis.
Results
In this study, we provide evidence indicating that activation of Hh signaling via expression of activated smoothened, SmoM2, is sufficient to induce fibrosis in the vasculature and aortic valves. We showed that activated SmoM2 -induced fibrosis is associated with abnormal function of aortic valves and heart. The relevance of this mouse model to human health is reflected in our findings that elevated GLI1 expression is detected in 6 out of 11 aortic valves from patients with diseased aortic valves.
Conclusions
Activating hedgehog signaling is sufficient to drive fibrosis in mice, and this mouse model is relevant to human aortic valve stenosis.
Efficacy of mHealth and education-led peer counselling of patients with hypertension and coronary artery disease in Pakistan: Study protocol for a double-blinded pragmatic randomized-controlled trial with factorial design
Authors: Arshed Muhammad , Zakar Rubeena , Umer Muhammad Farooq , Ullah Najeeb , Iftikhar Ghazala , Kiran Mehwish , Fischer Florian
Published: September 2022

Background: Hypertension is a highly relevant public health challenge. Digital interventions may support in improving adherence to anti-hypertensive medications and alter health behavior. Therefore, this protocol describes a study which aims to assess the effectiveness of mHealth and educational support through peer counseling (Ed-counselling) to control blood pressure in hypertensive patients when compared to standard care.
Methods: We chose a double-blinded pragmatic randomized-controlled with factorial design for this investigation. The trial is going to recruit 1440 hypertensive patients with coronary artery disease at the age of 21 to 70 years. All participants will already be on anti-hypertensive medication and own a smartphone. They will be randomized into four groups with each having 360 participants. The first group will only receive standard care; while the second group, in addition to standard care will receive monthly Ed-counselling (educational booklets with animated infographics and peer counselling); the third group will receive daily written and voice reminders and an education-led video once weekly together with standard care; while the fourth one gets both interventions given to second and third groups respectively. All groups will be followed-up for one year (0, 6, and 12 months). The primary outcome will be the change in systolic blood pressure while secondary outcomes include health-related quality of life and changes in medication adherence.
Discussion: Besides adding up to existing evidence in the literature on the subject, our designed modules using mHealth technology can help reducing hypertension-related morbidity and mortality in developing countries.
Trial registration: ClinicalTrials.gov (NCT05106790), October 24, 2021
Expression of an Insecticidal Protein under Phloem Specific Promoter in Cotton Plants to Control Whitefly
Authors: Hussain Sonia , Aslam Muhammad , Ahmed Nasim , Jamil Mahnoor , Rauf Imran , Aftab Shaheen , Amin Imran , Mansoor Shahid
Published: September 2022

Whitefly the Bemisia tabaci is a phloem sap-sucking hemipteran pest that causes enormous damage to many crop plants, particularly cotton. Bt endotoxins which successfully controlled the chewing pest proved to be mostly ineffective against the whiteflies and many other hemipteran pests. In the past few years, some insecticidal proteins showed significant toxicity against the whiteflies such as Hvt, lectin, and TMA12. In this study, transgenic cotton lines expressing plant-derived insecticidal protein TMA12 under constitutive promoter (2X35S derived from Cauliflower mosaic virus-CaMV) and a phloem-specific promoter (Nuclear shuttle protein-NSP derived from Banana bunchy top virus-BBTV) were developed to compare their efficacy against the whiteflies. Before developing cotton transgenic lines, tobacco transgenic plants were also developed to get preliminary results about the efficacy of the transgene. After molecular characterization, cotton transgenic lines were evaluated for resistance against whitefly in the contained environment. Whitefly survival and fecundity were calculated for each transgenic line. Bioassay data proved the effectiveness of insecticidal protein against whiteflies. These results also concluded that the NSP promoter is potentially an effective strategy against B. tabaci but still its efficiency is not equal to the 2X35S promoter. The use of a phloem-specific promoter has advantages over the constitutive promoter like tissue-specific expression saves the molecular resources of the plant cells and is less prone to biosafety concerns. In the future, more phloem-specific promoters can be explored for enhanced effectivity against B. tabaci.
Extended DNA threading through a dual-engine motor module in the activating signal co-integrator complex
Authors: Jia Junqiao , Hilal Tarek , Bohnsack Katherine , Chernev Aleksandar , Tsao Ning , Schwarz Juliane , Arumugam Aruna , Parmely Lane , Holton Nicole , Loll Bernhard , Mosammaparast Nima , Bohnsack Markus , Urlaub Henning , Wahl Markus
Published: September 2022

Activating signal co-integrator complex (ASCC) supports diverse genome maintenance and gene expression processes. Its ASCC3 subunit is an unconventional nucleic acid helicase, harboring tandem Ski2-like NTPase/helicase cassettes crucial for ASCC functions. Presently, the molecular mechanisms underlying ASCC3 helicase activity and regulation remain unresolved. Here, we present cryogenic electron microscopy, DNA-protein cross-linking/mass spectrometry as well as in vitro and cellular functional analyses of the ASCC3-ASC1/TRIP4 sub-module of ASCC. Unlike the related spliceosomal SNRNP200 RNA helicase, ASCC3 can thread substrates through both helicase cassettes. ASC1 docks on ASCC3 via a zinc finger domain and stimulates the helicase by positioning a C-terminal ASC1-homology domain next to the C-terminal helicase cassette of ASCC3, likely assisting the DNA exit. ASC1 binds ASCC3 mutually exclusively with the DNA/RNA dealkylase, ALKBH3, directing ASCC for specific processes. Our findings define ASCC3-ASC1/TRIP4 as a tunable motor module of ASCC that encompasses two cooperating ATPase/helicase units functionally expanded by ASC1/TRIP4.
The perceptions of university students on technological and ethical risks of using robots in long-term care homes
Authors: Young Erika , Hung Lillian , Wong Joey , Wong Karen , Yee Amanda , Mann Jim , Vasarhely Krisztina
Published: September 2022

Background
The COVID-19 pandemic has disproportionately impacted LTC residents and exacerbated residents’ risks of social isolation and loneliness. The unmet emotional needs of residents in LTC have driven researchers and decision-makers to consider novel technologies to improve care and quality of life for residents. Ageist stereotypes have contributed to the underuse of technologies with the older population. Telepresence robots have been found easy-to-use and do not require older adults to learn how to operate the robot but is remotely controlled by family members. There is a need for exploring perceptions around the implementation of these technologies with older adults living in long-term care.
Methods
Between December 2021 and March 2022, our team conducted interviews with 15 multidisciplinary students. We employed a qualitative descriptive (QD) approach with semi-structured interview methods. Our study aimed to understand the perspectives of university students (under the age of 40) on using telepresence robots in LTC homes. Participants were given a link to a 2-minute video of how the robot works prior to the interview. Also, they were invited to spend 15 minutes remotely driving a telepresence robot prior to the interview. A diverse team of young researchers and older adults (patient and family partners) conducted reflexive thematic analysis together.
Results
Six themes were identified: (1)Robots as supplementary interaction, .(2) privacy, confidentiality, and physical harm, (3) increased mental well-being and opportunities for interactions. (4) intergenerational perspectives add values , (5) staffing capacity (6) environmental and cultural factors influence acceptance
Conclusion
We identified a generational difference in opinions and thoughts regarding risk and privacy of using telepresence robots in long-term care. Participants shared the importance of the voice of the resident and their own for creating more equitable decision-making and advocating for including this type of technology within long-term care. Our study would contribute to the future planning, implementation, and design of robotics in LTC.
Auto-identification of dominant modal parameters from multi-batch signals based on weighted-SSA to suppress milling vibration
Authors: Peng Yili , Chen Xubing , Jiang Xuchu , Huang Kuntao , Fu Zhongtao
Published: September 2022

Facing the characteristics of big data in modern industrial system, manually retrieving the data from many different batches of vibration signals for modal analysis will cause low data utilization and low efficiency. At the same time, under cutting condition, the harmonic component generated by the rotating excitation of machine tool interferes the auto-identification of structural modal parameters from a large number of vibration signals. Therefore, to realize the auto-identification of structural dominant modal parameters from large amounts of different batches vibration data under cutting condition, a new weighted-SSA (singular spectrum analysis) method is proposed in this paper. First, multi batch on-site vibration signals are decomposed, and the eigenvalue and matrix are extracted through singular value decomposition. Then, based on the variance filtering of principal component analysis, a half principal component analysis is proposed to extract the weighted vector of the eigen matrix. and clustering is adopted to average the noise reduction signals, to realize the automatic screening of a large amount of data and the automatic distinction of modal parameters. Third, the identified dominant mode of the structure with weak link is optimized through the genetic algorithm, to achieve the suppression of spindle tool system vibration. Finally, the cutting tests are conducted to verify the feasibility and effectiveness of the auto-identification and optimization method.
Prevalence of Perinatal Factors in Infants with Brachial Plexus Birth Injuries and their Association with Injury Severity
Authors: Manske Mary Claire , Miller Patricia , Bauer Andrea
Published: September 2022

Objectives
To determine the prevalence of perinatal factors associated with brachial plexus birth injury(BPBI) in affected infants and their relationship with BPBI severity.
Study Design
Retrospective study of BPBI infants prospectively enrolled in a multicenter registry. The prevalence of perinatal factors were calculated. Infants were stratified by injury severity and groups were compared to determine the association of severity and perinatal factors.
Results
Seven-hundred-ninety-six BPBI infants had a mean 4.2 ± 1.6 perinatal factors. Nearly all (795/796) reported at least one factor, including shoulder dystocia(96%), no clavicle fracture (91%), difficult delivery(84%), parity > 1(61%) and birthweight > 4000g(55%). Ten-percent (74/778) had Horner’s syndrome and 28%(222/796) underwent nerve surgery. Birth asphyxia and NICU admission were significantly associated with injury severity.
Conclusions
NICU admission and asphyxia were associated with BPBI severity. Improved understanding of the relationship between perinatal factors and BPBI severity may be used to guide early referral to BPBI providers and support prevention efforts.
Comparision of Hydrological Forecast Methodologies Applied to a Small Mountain Watershed
Authors: Fagundes Marina , Fan Fernando Mainardi , Gama Cléber Henrique de Araújo , Campagnolo Karla , Paixão Maurício Andrades , Kobyiama Masato
Published: September 2022

A comparison of methodologies was carried out to develop an operational flow forecasting system for a mountainous basin. The case studied was the Boi river, which is located in a small mountainous watershed in southern Brazil. This watershed is part of a conservation unit well known for the ecotourism activities carried out in that place. Among the activities, the Boi river trail can be highlighted, which is carried out following the riverbed. For this reason, the development of an alert system for this basin can help in determining the trail's closure in situations where the water flow is strong and could present risks to tourists safety. Thereby, two different scenarios were considered for the development of the forecasting system. First, the flow forecasts were performed using SOPREVA and considered a horizon of 1 day (short term forecasts). The second scenario considered medium-term forecasts (1 to 10 days horizon) and utilized the HEC-RTS as a basis for developing the forecast system. In both cases, the forecasts were based on the ensemble precipitation estimates of GEFS. The obtained results showed that the actual alarm rates were 0.77 and 0.86 for SOPREVA and HEC-RTS, respectively, when considering a horizon of one day in advance. The evaluation of the medium-term forecasts presented good results of this system for horizons up to 3 days in advance. Finally, the results of both considered scenarios showed that the systems could be used as a basis for management of the Boi river trail.
Postoperative arrhythmia after lower gastrointestinal surgery- the blind spot of postoperative care?
Authors: Rühlmann Felix , Hedicke Mara Sophie , Engelhardt Deborah , Mackert Alma Franziska , Tichelbäcker Tobias , Leha Andreas , Bernhardt Markus , Ghadimi Michael , Perl Thorsten , Azizian Azadeh , Gaedcke Jochen
Published: September 2022

Introduction: Postoperative arrhythmias (PAs) are common events and have been widely investigated in cardiothoracic surgery. Within visceral surgery, a recent study revealed a significant occurrence of PA in esophageal resections. In contrast, PA in lower gastrointestinal surgery is rarely investigated and has been rudimentary described in the medical literature.
Methods: In total, 1171 patients (559 female, 612 male) without any history of prior arrhythmia who underwent lower GI surgery between 2012 and 2018 were included and retrospectively analyzed. All included patients were treated and monitored in the intensive care unit (ICU) or intermediate care unit (IMC) after surgery. Follow-up was obtained for the patients with PA investigating the possible persistence of PA and complications such as permanent arrhythmia or thromboembolic events after discharge.
Results: Overall, PA occurred in n=56 (4.8%) patients after surgery of the lower GI. The highest incidence of PA was seen in patients undergoing bowel surgery after mesenteric ischaemia (26.92%), followed by cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC; 16.67%). PA was significantly associated with higher age (p<0.001) and longer length of stay in the ICU (p<0.001). PA was independently associated with organ failure (p<0.001) and higher in-house mortality (p<0.001). In median, PA occurred 66.5 hours after surgery. In follow-up, 31% of the patients showed development of permanent arrhythmia.
Discussion: The incidence of PA after lower GI surgery is comparatively low. Its occurrence, however, seems to have severe implications since it is significantly associated with higher rates of organ failure and in-house mortality. Also, compared to the general population, the development of permanent arrhythmia is significantly higher in patients who developed new-onset PA.
Quantitative flow ratio vs. angiography- only guided PCI in STEMI patients: a one- year outcomes
Authors: Barauskas Mindaugas , Žiubrytė Greta , Jodka Nojus , Unikas Ramūnas
Published: September 2022

Background

Coronary physiology-guided PCIs are recommended worldwide. However, invasive coronary physiology methods prolong the procedure, make additional risks for the patients, and prolong the fluoroscopy time for an interventional cardiologist. Otherwise, there is a non-invasive coronary physiology evaluation method QFR, which can be safely used even in STEMI patients.

Methods

198 patients admitted with STEMI and at least one intermediate (35–75%) diameter stenosis other than culprit artery between July 2020 and June 2021 have been prospectively included in this single-centre study. All patients were randomized into one of two groups (1 - QFR-guided PCI; 2 - visual-estimation-only guided PCI). A 12-month follow-up with echocardiography, exercise stress test, and quality of life evaluation was performed in all included patients. For the QOF evaluation, the Seattle angina score questionnaire was chosen. Statistical analysis was performed using Kolmogorov-Smirnov, Stjudent T, Mann-Whitney, Pearson Chi-square tests and Kaplan Meier survival analysis.

Results

98 (49.5%) patients were randomized to the first group, and 100 (50.5%) patients were included in the second group. Statistically, significantly more patients had a medical history of dyslipidaemia (98 vs 91, p = 0.002) and slightly better left ventricular ejection fraction (42.21 ± 7.88 vs 39.45 ± 9.62, p = 0.045) in the QFR group. Six times fewer patients required non-culprit artery revascularization within 12-month FU in the QFR group (1.02% vs 6%, p = 0.047). Survival analysis proved that patients in the Angio group had more than 6-time greater risk for death within a 12-month period after MI (OR 6.23, 95% CI 2.20-17.87, p = 0.006), with the highest mortality risk within the first two months after initial treatment.

Conclusions

Using QFR in non-culprit lesions for patients with ST-elevation myocardial infarction reduces mortality rate and revascularization in 12-month follow-up and increases the patient's quality of life.

Trial registration

The study was approved by the Regional Bioethical Committee and conducted under the principles of the Helsinki Declaration and local laws and regulations.
Experimental investigation and numerical Analysis using Taguchi and ANOVA Method for Underwater Friction Stir Welding of aluminium alloy 2017 process improvement
Authors: madani tahar , BOUKRAA mousatfa , aissani mouloud , chekifi tawfiq , ziadi abdelkadar , zirari mounir
Published: September 2022

The effect of under water friction stir welding for 5 mm AA2017 aluminum alloy plaque on mechanical properties has been examined, nine different test were designed according to Taguchi orthogonal array (OA) without changing the welding tool. Three variable operating parameters (Welding velocity, rotational velocity and axial force) with three levels for each parameter have been used. The effects of each FSW parameters on the weld joint were discussed and analysed, the analysis of variance (ANOVA) is adopted to identify the contribution of each FSW underwater parameters. The statisticl Taguchi method (MT) was employed to pridect the optimal combination of welding parameters to improve the tensile properties such tensile strength (TS) of welded joints as retaining high production rates. The experimental tests show good agreement with the results estimated by the proposed mathematical model. Where the obtained validation results confirm the robustness of the optimization method as a tool for improving the quality responses of under water friction stir welding.
The Case for Minimax-TD
Authors: Darlington Richard B.
Published: September 2022

In spatial-model computer simulations with artificial voters and candidates, the well-known minimax single-winner voting system far outperformed 10 other systems at picking the best winners. It essentially tied with two others (Schulze and ranked pairs), both of which are far more complex than minimax. Minimax’s other advantages include Condorcet consistency, simplicity, monotonicity, and ease of voting because it allows tied and missing ranks. It also makes insincere strategic voting schemes difficult and dangerous for the schemers. The new minimax-TD system modifies minimax in three ways, all of which make it pick better winners, according to simulation studies: (a) TD includes Smith/minimax, (b) TD uses one particular definition of a candidate’s “largest loss” in two-way elections, and (c) TD includes a multi-stage tie-breaker which breaks nearly all ties. TD avoids four of the worst anomalies afflicting classic minimax. Four other minimax anomalies can be ignored, leaving TD arguably free of anomalies.
JEL Classification D71 D72
circKIF4A promotes proliferation and brain metastasis in triple-negative breast cancer through autophagy by sponging miR-637
Authors: Wu Song , Li Xing , Zhu Lewei , Wu Feiyue , Zhang Yue , Wu Linyu , Lu Jibu , Li Yuehua , Tang Hailin
Published: September 2022

Background
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression is greatly facilitated by circKIF4A, but uncertainty remains regarding the role of which in TNBC brain metastasis and its molecular mechanism.
Methods
In this study, RNA sequencing was used to identify circKIF4A from 22 pairs of primary breast cancer and brain metastases. Validation of circKIF4A expression and existence was performed using FISH and RT-qPCR assays. It was demonstrated that circKIF4A plays an oncogenic role both in vitro and in vivo. Western blot and dual-luciferase reporter assays were used to confirm the interaction of circKIF4A, miR-637, STAT3, p62 and beclin.
Results
In this study, we detected notable upregulation of circKIF4A in TNBC cell lines and brain metastasis. Inhibition of circKIF4A impairs TNBC’s ability to proliferate, migrate, and brain metastasis. Luciferase reporter assays confirmed that circKIF4A competed for binding to miR-637 with STAT3. Western blot analysis revealed that inhibition of circKIF4A decreased STAT3 and p62 expression, and increased the expression of Beclin, confirming that downregulation of circKIF4A induced autophagy by competing with STAT3 to bind to miR-637.
Conclusion
By employing competitive endogenous RNA (ceRNA) mechanism, the circKIF4A-miR-637-STAT3 axis coordinates TNBC brain metastasis. circKIF4A can therefore be used as a prognostic biomarker for TNBC brain metastasis and as a therapeutic target.