bluuebunny/crossref_metadata_2025 huggingface dataset:
Early Detection of Javanese Phonological Awareness of Grade 4 Elementary School Students
Authors: Maruti Endang Sri
Published: June 2021

This study aim to detect the phonological awareness of Javanese in elementary school grade 4 students early through the distance learning process. To be able to determine the level of awareness of children's phonology, one indicator is to look at the child's ability to write and read Javanese text. This research is a descriptive qualitative type. Data was collected by archiving all assignments related to writing and reading Javanese text sent by students through the WhatsApp application. The collected data were then analyzed descriptively. The results showed that grade 4 elementary school students made many phonological errors when writing and reading Javanese text. The most common mistakes are when writing vowels /a/ and reading consonants /dh/ and /th/. Based on the many errors, it can be concluded that the phonological awareness of Javanese elementary school students is still low, or it can be said to be less aware.
The Ecological Impact of the Covid-19 Pandemic Infodemic Discourse in Social Media: Ecolinguistic Perspectives
Authors: Khotimah Khusnul , Laksono Kisyani , Suhartono Suhartono , Pairin Udjang , Darni Darni
Published: June 2021

Texts on social media often highlight the Covid-19 pandemic. The text influences the mindset and mode of the readers. The purpose of this study is to describe the potential ecological impacts of infodemics, both constructive and destructive for readers. Data sourced from social media (Facebook, Instagram, and Twitter). The method used in this research is a qualitative approach with descriptive methods. The results showed that the ecological impact of infodemic discourse, namely the constructive impact represented by the content, meaning or message can influence the mindset and attitudes of readers to participate in preserving the environment. Positive texts can change negative environmental ethics into positive ones. The destructive impact in the form of excessive use of text, and without clear sources, has an impact on the effects of distraction, mental health, panic buying, confirmation bias and echo chambers, and tends to refuse to protect oneself and heed health protocols, making it difficult to handle the outbreak. In addition, misinformation on health has an impact on exacerbating outbreaks of infectious diseases. Especially damaging advice as false information is crafted with no respect for accuracy and is often integrated with narratives framed by emotion or conspiracy. The text affects attitudes and mindsets so that it damages the environment.
Social Mapping of Cultural Production : Strategies in dealing with the decline in tourism due to the Covid19 pandemic in Penglipuran Village, Bali
Authors: Lamopia I Wayan Gede , Wulandari Riza , Yunianti Isma Illia Shara
Published: June 2021

Panglipuran village is a reflection of balinese in the field of tourism. In anticipating the decrease of visitors in Panglipuran due to the covid19 pandemic, it is necessary to conduct a scientific study, namely social mapping of cultural  production. The study aims to ease the people in Panglipuran village to explore the potential of the village to recover economic condition due to the decrease of tourists. Based on the bordieu paradigm and field observation, there are four potential assets in dealing with the crisis, namely symbolic, cultural, economic, and social assets.
The Relationship Between Empowerment And Job Satisfaction on Employee Performance in Majalengka Regency
Authors: Ratna Ratna , Maharani Dewi
Published: June 2021

This study aims to see the relationship between empowerment and job satisfaction on employee performance in Majalengka Regency. This research uses a quantitative approach, with survey methods and path analysis techniques. The sample in this study were employees in the Majalengka environment with a sample size of 80 employees. The data collection technique in this research is by using a questionnaire containing several lists of statements. The results showed that (1) employee performance was directly affected by empowerment. Increased empowerment would result in an increase in performance of 3.2%. (2) Increased job satisfaction will result in an increase in employee performance by 19%. (3) job satisfaction is directly affected by empowerment, increasing empowerment will result in an increase in satisfaction by 12%.
Drivers of Women Entrepreneurship in the Autonomous Region in Muslim Mindanao
Authors: DBA Emraida C. Ali , DBM Noraida C. Ali
Published: June 2021

This is a quantitative study conducted to analyze the drivers of women entrepreneurship in the Autonomous Region in Muslim Mindanao. The descriptive- correlation research design was used to execute the research and analyze the data. The respondents were the selected women entrepreneurs in the provinces of Maguindanao, Lanao del Sur, Basilan, Sulu and Tawi-tawi. A modified research questionnaire was used in this study as the main data-gathering instrument. Data were analyzed using the frequency, percentage, mean, and multiple regression analysis. The personal entrepreneurial competency, presence of entrepreneurial role model, government programs and interventions, motivation are studied whether it influence the extent of women entrepreneurship in terms of involvement in the four phases of entrepreneurial activity: searching; planning; marshaling; and implementing. Results of the study revealed that significant predictors are the personal entrepreneurial competency, government programs and interventions, and motivation. Among these significant predictors, the personal entrepreneurial competency has the highest contribution thus making it the best predictor of women entrepreneurship
Local Management Conflict Resolution Among Elementary Schools Principals In Maguindanao
Authors: Sittie Maguid-Kusin  , Zainodin M. Kusin
Published: June 2021

The basic function of school principal is to resolve conflicts and this needs skillful principals to handle those problems, to come up with peaceful solutions and outcomes. The main focus of the study was to determine the Local Management Conflict Resolution among Elementary Schools Principals in Maguindanao. The descriptive correlation method of research was used in this study. It was conducted at 20 Central Elementary Schools in Maguindanao -1 Division with a total of 150 teachers participated in the study. The data gathered were analyzed using SPSS. The statistical tools used were weighted average mean and regression analysis.The Level of Conflict Resolution Skills of Elementary Schools Principals in Maguindanao were rated negotiated that described their skills in conflict resolution in terms of negotiation with a grand mean of 3.42, Mediation were rated highly mediated with a grand mean of 3.57. The Extent of conflict management of the Elementary Schools Principals in the Province of Maguindanao to manage conflict of teachers vs teachers were rated satisfactory with a grand mean of 3.31, teachers vs pupils 3.35. Moreover, the conflict resolution skills of elementary schools principals in Maguindanao were manifested and conflicts were managed most of the time by the principals. The influence between the levels of conflict resolution skills of elementary schools principals in Maguindanao to principals’ management was Significant. It is recommended that conflict resolution skills of elementary schools principals in Maguindanao need to improve and strengthen it for self-development to manage all the time the conflicts very well.
Childhood Onset Exercise Addiction or Atypical Anorexia Nervosa during Covid-19: Case Report
Authors: mcnicholas fiona
Published: June 2021

Background: Childhood-onset Anorexia Nervosa is recognised to be atypical in presentation, both in terms of extent and nature of eating pathology, exercise and compensatory behaviours with many falling short of full diagnostic criteria. Failure to consider an eating disorder diagnosis in youth who present with extreme weight loss may have serious immediate and long term implications. However, failure to consider other non-organic causes of weight loss may be equally detrimental to the child’s health. Case Presentation: This case reports on the acute presentation of a 12-year old boy with no prior eating concerns, who presented to hospital in a severely malnourished state eight weeks into lockdown. To compensate for Covid-19 induced restrictions on sporting activity, this boy had followed a self-imposed daily schedule of arduous exercise, without increasing his nutritional intake. This report examines the clinical features suggestive of Anorexia Nervosa and other differential diagnosis. A discussion on the specific diagnostic differential of exercise addiction and challenges faced by youth during Covid-19 restrictions are presented. Conclusion:Accepting that Anorexia Nervosa may present atypically in pre-pubertal youth, it is important that clinicians maintain an open mind in youth presenting without goal directed weight loss. Although weight loss was significant in this case, it was due to an excessive exercise regime. This may have commenced as a coping strategy in response to Covid-19 restrictions but subsequently became excessive and impairing in nature. The collateral damage of Covid-19 mandated restrictions, aimed at containing the spread of the virus, are evident in this case. Clinicians need to be alert to potentially maladaptive coping strategies and unusual or altered pathways of presentation, especially in younger children during these challenging times.
Synthesis of Silver Nanoparticles through Orange Peel Powder for Antibacterial Composite Filler Applications
Authors: Subbiah Rathinavel , Saravanakumar S. S.
Published: June 2021

Environmental concerns and the positive aspects of biowaste materials gained the attention of researchers to use them as filler materials in fabricating of green composites along with polymer matrices, but most of them are not suitable for extensive applications in high thermal applications. In most of the natural particulate materials are not having the ability to fight against pathogens. To overcome such barriers, a modification of biowaste - Orange Peel Powder (OPP) by the generation of silver nanoparticles (AgNPs) is prepared with the one-step hydrothermal process. The modified Orange Peel Powder (MOPP), is then characterized by FESEM, EDX, FT-IR, XRD, and Thermal analyses. The presence of AgNPs in the MOPP is confirmed through FESEM & EDX analysis. FT-IR spectral analysis pronounced the non mutate functional groups in MOPP as compared with OPP. The generation of AgNPs in MOPP is confirmed through the XRD peaks of reflection planes at (1,1,1), (2,0,0), (2,2,0) & (3,1,1). Thermal Analysis results of TGA and DSC show the MOPP has increased thermal stability up to 363°C. Antibacterial test against Gram-negative and Gram-positive bacteria for OPP & MOPP shows the inclusion of Ag strongly objects the pathogens. Eventually, the MOPP can be utilized as filler material along with the polymer matrix in high thermal as well as antibacterial composite filler applications.
Developing Horizontal Subsurface Flow Constructed Wetland using Pumice and Chrysopogon zizanioides for Tannery Wastewater Treatment
Authors: Aregu Mekonnen Birhanie , Asfaw Seyoum Leta , Khan Mohammed Mazharuddin
Published: June 2021

Background: High-strength wastewater defined by elevated levels of hazardous pollutants measured in BOD, heavy metals, nutrients and other toxic substances. This kind of wastewater discharged to water body without treatment from different industrial sectors that adversely affects aquatic environment and downstream water consumers. The general objective of this study is to investigate efficient substrate with selected plant type for constructed wetland to remove hazardous pollutants from tannery wastewater. This study was conducted at Modjo town from 2016 to 2018. Plug flow experimental study design was carried out. The substrate (Pumice) was collected around the study area and chemical characteristics were determined. Chrysopogon zizanioides was planted and grown for five months before running tannery wastewater for the treatment. The composite wastewater was introduced to the constructed wetland from Modjo leather industry, Ethiopia. The physicochemical analysis of the sample wastewater was done before and after treatment at four different hydraulic retention time. Results: Characterization of the untreated tannery wastewater revealed that the mean concentration of BOD5, COD, TSS, PO4-P, TP, NO3-N, TN and total chromium were 1641±373.6, 6953.33±339.4, 1868±863.1, 88.06 ±40.8, 144.53 ±20.8, 116.66 ±26.6, 650.33 ±93.6 and 18.33±6.7 mg/l respectively beyond the permissible limits. The maximum removal efficiency of the constructed wetland in pumice bed revealed that BOD5 at HRT 7and 9 days (96.42%, 96.30%), COD at HRT 5 and 7 days (96.76%, 96.91%), NO3-N at HRT 5 and 7 days (99.99%, 99.68%), TN (98.67%, 99.00%), PO4-P HRT 7and 9 days (96.97%,100%), TP at HRT 5 and 7 days (94.79%, 96.17%) and total Chromium at HRT 5 and 7 days (98.36%, 98.91%) respectively. Whereas, the removal efficiency of constructed wetland bed with gravel substrate used as a control subject with similar condition to pumice showed lower performance. The result between pumice and gravel bed was tested for their significance difference using two sample t-test statistics. Based on the test statistics, the pumice substrate perform better than the gravel significantly at 95% confidence interval, p-value = 0.01. Conclusion: Pumice substrate and Chrysopogon zizanioides have a potential ability to remove hazardous pollutants from tannery wastewater in horizontal subsurface constructed wetlands.
A Zirconium Metal-Organic Framework with SOC Topological Net for Catalytic Peptide Bond Hydrolysis
Authors: Wang Sujing , Ly Hong Giang T , Wahiduzzaman Mohammad , Dovgaliuk Iurii , Tissot Antoine , Maurin Guillaume , Parac-Vogt Tatjana , Serre Christian
Published: June 2021

The discovery of nanozymes for selective fragmentation of proteins would boost the emerging areas of modern proteomics, however, the development of efficient and reusable artificial catalysts for peptide bond hydrolysis is challenging. Here we report the detailed catalytic properties of a microporous zirconium carboxylate metal-organic framework, MIP-201, in promoting peptide bond hydrolysis in a simple dipeptide, as well as in horse-heart myoglobin (Mb) protein that consists of 153 amino acids. We demonstrate that MIP-201 features an excellent catalytic activity and selectivity, a good tolerance toward reaction conditions covering a wide range of different pH values, and importantly, an exceptional recycling ability associated with easy regeneration process. Taking into account the excellent catalytic performance of MIP-201 and its other advantages such as 6-connected Zr6 cluster active sites, the green, scalable and cost-effective synthesis, and an outstanding chemical and architectural stability, our finding suggests that MIP-201 may be a promising and practical alternative to the current commercially available catalysts for peptide bond hydrolysis.
Using Multi-Fractal and Joint Multi-Fractal Theories to Characterise the Spatial Variability of Soil Particle Size Distribution in an Underground Coalmine Area
Authors: Li Sijia , Wang Jinman , Zhang Jiarui , Zhang Min
Published: June 2021

Underground coal mining leads to serious surface deformation, which negatively affects the physical properties of soils Soil particle size distribution (PSD) is one of the most basic soil physical characteristic that influences other important properties such as soil hydraulics and thermodynamics. Understanding the spatial variability of the soil PSD in subsided land can provide targeted guidance for land reclamation. In this study, we conducted a quantitative study on the spatial variability of the soil PSD in the Pingshuo mining area on the Loess plateau, Shanxi Province in China, and explored the effects of subsidence and reclamation on the soil PSD. A plot experiment, including one unmined plot (UMP), one subsided plot (SUP), and one reclaimed plot (RCP), was performed in Anjialing No.3 underground coal mine in the, Pingshuo mining area. Four multi-fractal parameters of the soil PSD—D(0), D(1), Δα(q), and Δf(α)—were analyzed at the three sample sites. The joint multi-fractal method was carried out to analyze the spatial correlation of the soil PSD to further reveal the impacts of coal mining subsidence and land reclamation on the soil PSD. The multi-fractal method can reflect the local non-uniformity and heterogeneity of the soil PSD, while the joint multi-fractal approach can illustrate the correlation of the soil PSD between different soil depths. The range and spatial variability of the soil PSD increased due to coal mining subsidence and the impact of subsidence on the spatial disturbance of the surface soil PSD was greater than that of the deeper layers. The spatial correlation of clay in subsided land was larger than those of unmined land and reclaimed land, whereas, for silt and sand, the correlation was smaller. Land reclamation decreased the spatial variability of the soil PSD, which was near that of the unmined land after reclamation.
Physical Activity Levels, Exercise Preferences, and Exercise Barriers in Children and Adolescents after Cancer Treatment
Authors: Kim Ji Young , Yoo Samuel , Yeon Su Jin , Min Ji Hee , Kim Dong-il , Lee Ji Won , Han Jung Woo , Lyu Chuhl Joo , Jeon Justin
Published: June 2021

Purpose: The purpose of the current study was to explore physical activity (PA) and exercise participation, exercise preferences, and barriers to PA in childhood cancer survivors.Methods: We surveyed 120 childhood cancer survivors in childhood and adolescence from the pediatric oncology center in South Korea between March and August 2017. The modified Exercise & Quality of Life questionnaire, Korea Youth Risk Behavior Web-based Survey, and Godin Leisure-Time Questionnaire were used to assess PA levels, preferences, and exercise barriers.Results: Among 120 participants (72 boys, 48 girls) whose average age at the time of the survey was 14.57 ± 3 years and average age at diagnosis was 8.22 years, only 6.9% of male participants and 2.1% of female participants met the PA recommendations for children (at least 60 min of moderate PA per day). The most preferred sporting activities included soccer, basketball, strengthening exercises, badminton, dance, and taekwondo. They generally had positive attitudes toward exercise, and more than 63% of participants intended to exercise the following month. The four most prevalent perceived barriers to exercise were lack of time, poor health, reluctance to sweat, and lack of exercise skills. Conclusions: While most childhood cancer survivors did not meet the PA recommendation, most of them agreed that exercise was beneficial, and they intended to participate in exercise. Exercise and PA programs should be tailored to the personal health and preferences of childhood cancer survivors to increase PA and exercise participation in this group.
Wind Intensity and Power Density in the Brazilian Dry Tropical Forests (Caatinga)
Authors: Silva Madson Tavares , de Sousa Welinagila Grangeiro , Cavalcanti Enilson Palmeira , Silva Vicente de Paulo Rodrigues da , Serrão Edivaldo Afonso de Oliveira
Published: June 2021

Wind speed has been widely used for energy purposes. Therefore, studies focused on its knowledge are extremely relevant to better benefit from this resource. The aim of this study is to analyze wind behavior and estimate wind power density (WPD) in the interior of northeastern Brazil, a region with predominance of the semi-arid climate, based on the data made available by the automatic station installed at the Experimental Farm in the municipality of São João do Cariri-PB, which come from the SONDA project and refer to the year 2007. Descriptive analysis techniques were used to identify the periods in which the wind behavior is more favorable to wind harnessing. From the results obtained, there was a predominance of southeast in the wind direction component. However, the values of both the observed wind speed (2, 25 and 50 m) and the wind speed estimated for the levels of 100 and 150 m, as well as the estimates of power density (50, 100 and 150 m) showed that the lowest records are present mainly in the first hours of the day, as well as in the first half of the year, while the highest values occur from 10 a.m. extending to the beginning of the night and prevail in the last six months of the year. These determinations denoted higher values of wind power density available for the second half of the year (mainly from August to December).
Olive Landscape Affects Bactrocera Oleae Abundance, Movement and Damage
Authors: Ortega Marta Quero , Moreno Natalia , Fernández Cristina E. , Pascual Susana
Published: June 2021

The olive fruit fly, Bactrocera oleae (Rossi) (Diptera: Tephritidae), is a key pest of olive groves. Because of its economic importance and problems associated with chemical control, new approaches to reduce the damage caused by this pest and a deeper knowledge of the biology of the insect and the relationship of landscape structure to different biological parameters are needed. B. oleae can fly long distances and its ability to move within the landscape can determine the damage caused to olive groves. This work evaluates the effect of landscape structure on olive fruit fly abundance, movements and damage at three times of year—spring, early autumn and late autumn—in central Spain. This area is less dominated by olive groves than southern Spain, where the relationship between olive grove area and B. oleae abundance is already known. A cost-distance analysis is used to evaluate the landscape effect on the movement of the fly along the crop cycle. The olive grove area is the landscape composition factor with the greatest effect on the parameters studied, with a decrease in B. oleae abundance in a more complex landscape during spring and early autumn. The cost-distance analysis shows that the olive fruit fly moves mainly in spring, and amongst olive groves. There is no evidence that land uses other than olive groves serve as a summer refuge for B.oleae in the studied landscape context. Olive grove area and land use diversity index had significant effects on olive damage in more than one year.
Superparamagnetic Iron Oxide Nanoparticles Induce Apoptosis in HT-29 Cells by Increasing ROS and Damaging DNA
Authors: Ranjbary Ali Ghorbani , Saleh Golnaz Karbalaei , Azimi Mohammadreza
Published: June 2021

Today, research into nanoparticles for diagnostic and therapeutic use in cancer is on the rise. In the present study, the effect of superparamagnetic iron oxide nanoparticles on the formation of apoptosis in HT-29 cells is investigated.In this study, we investigated the mechanisms of apoptosis induced by superparamagnetic iron oxide nanoparticles after MTT assay and determining the appropriate dose of 2.5 µg / mL to induce apoptosis in HT-29 cells.Superparamagnetic iron oxide nanoparticles increased the levels of ROS, Ca2 +, and DNA damage in HT-29 cells. Also, at the level of protein and mRNA, they increased the expression of Caspes 3 and 9 and significantly decreased Bcl-2 compared to the control group (P <0.0001).Fe3O4 causes apoptosis in cancer cells by increasing the level of ROS and intracellular calcium, followed by increasing the expression of caspases 3 and 9 and decreasing the expression of Bcl-2, as well as direct DNA damage.
Order Reduction based on Coulomb’s and Franklin’s laws Algorithm
Authors: Kumar Ram , Sikander Afzal
Published: June 2021

The Coulomb and Franklin laws (CFL) algorithm is used to construct a lower order model of higher-order continuous time linear time-invariant (LTI) systems in this study. CFL is quite easy to implement in obtaining reduced order model of large scale system in control engineering problem as it employs the combined effect of Coulomb’s and Franklin’s laws to find the best values in search space. The unknown coefficients are obtained using the CFLA methodology, which minimises the integral square error (ISE) between the original and proposed ROMs. To achieve the reduced order model, five practical systems of different orders are considered. Finally, multiple performance indicators such as the ISE, integral of absolute error (IAE), and integral of time multiplied by absolute error were calculated to determine the efficacy of the proposed methodology. The simulation results were compared to previously published well-known research.
Comprehensive Analysis of Expression, Prognosis and Immune Infiltrates for Kinesin Superfamily Members in Human Pancreatic Adenocarcinoma
Authors: Chen Zehao , Wang Jie , Xu Jian , Zhu Wenjie , Jiang Jianxin
Published: June 2021

BackgroundKinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of pancreatic adenocarcinoma (PAAD). However, the expression level of different KIFs in PAAD and its relationship with the prognosis and immune infiltration in patients with PAAD have not been fully elucidated.MethodsComprehensive bioinformatics analyses were done using data from UCSC XENA data hubs, TCGA database，Oncomine databases, GEO datasets, GEPIA, GTEx, The human protein atlas, Kaplan Meier plotter, cBioPortal, STRING and KEGG database. Then, the relationship between KIFs expression and tumor immune infiltrates was studied by using the TIMER database. ResultsA total of 24 differentially expressed KIFs at transcriptional levels were identified between tumor tissues and normal tissues with 1 (KIF1A) downregulated and 23 (KIF2A, KIF2C, KIF3A, KIF3B, KIF3C, KIF4A, KIF5B, KIF7, KIF9, KIF10, KIF11, KIF13A, KIF13B, KIF15, KIF16B, KIF18B, KIF20A, KIF20B, KIF21B, KIF22, KIF23, KIF26B, KIFC1) overexpressed by GEPIA. The protein expression level of KIF3A, KIF3B, KIF4A, KIF5B, KIF7, KIF9, CENPE, KIF11, KIF13A, KIF13B, KIF15, KIF16B, KIF18B, KIF20A, KIF20B, KIF21B, KIF22, KIF23, KIF26B, KIFC1 are higher in PAAD tissues than in the adjacent tissues, which is almost the same as the results of KIFs at transcriptional levels in PAAD. In addition, the expression levels of KIF1A, KIF1C, KIF3A, KIF5A, KIF5C, KIF6, KIF9, KIF13B, KIF19A, KIF21A, KIF24, KIF26B, KIFC1 are significantly correlated with the tumor stage of PAAD patients. As for prognosis value, the abnormal expression of KIF2C, KIF4A, KIF11, KIF15, KIF18B, KIF20A, KIF20B, KIF21B and KIF23 in PAAD patients is significantly related to the worse overall survival (OS) and relapse-free survival (RFS), and based on this, a 5-KIFs-based (KIF15, KIF20A, KIF20B, KIF21B, KIF23) risk score was generated by LASSO regression with a nomogram validated an accurate predictive efficacy. GO and KEGG enrichments revealed functions and pathways affected in PAAD. We also found that the expression of the 5-KIFs was significantly correlated with immune infiltrates, including B cells, CD8+ T cells, CD4+T cells, neutrophils, macrophages, and dendritic cells.ConclusionOur study may provide new insights into the choice of prognostic biomarkers and immunotherapy targets in PAAD patients.
Combinatorial Bioinformatics Analysis Reveals Novel Biomarkers for Improved Ovarian Cancer Prognosis
Authors: Zhang Xiaoyi , Zhu Shihong , Peng Min , Ma Hongbo
Published: June 2021

Background: Given the known lethality of highly frequent ovarian cancer (OC) among females, it is imperative to investigate potential biomarkers of prognostic and therapeutic significance. The objective of this study was to identify significant differentially expressed genes (DEGs) with poor prognosis and to explore their underlying mechanisms. Methods: We acquired three microarray datasets (GSE14407, GSE36668 and GSE18520), available from the public database GEO. We compared a total of 72 cancerous and 26 normal samples originating from ovarian tissues. GEO2R and Venn diagram tools were used to obtain DEGs, followed by the gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) analysis via Database for Annotation, Visualization and Integrated Discovery (DAVID). Subsequently, protein-protein interaction (PPI) network was constructed and visualized in Cytoscape. Results: Among three analyzed datasets, a total of 232 DEGs were common. The upregulated 108 genes were significantly enriched in the cell adhesion, cellular response to interleukin-1, positive regulation of transcription from DNA/RNA, and transcription, extracellular matrix/region, anchored membrane component, cell junction and golgi membrane, sequence-specific DNA binding, transcription factor activity, RNA polymerase II regulatory region, and DNA binding. The PPI network analysis via MCODE plug-in revealed a total of 14 upregulated genes. Kaplan-Meier plotter analysis revealed that 9 genes were associated with significantly worse survival among OC patients while 4 genes exhibited no significant effect. Gene Expression Profiling Interactive Analysis (GEPIA) showed that 13 DEGs had significantly higher expression in the ovarian cancerous tissues compared to the normal ones. Repeated KEGG analysis showed that 11 genes (CDC6, CCNE1, BUB1B, CCNB2, BUB1, SFN, TTK, CDC20, PTTG1, CDK1 and CDKN2A)) were mainly associated with cell cycle while 2 genes (SFN and RRM2) were related to p53 signaling pathway. Conclusion: Our findings identify potential upregulated DEGs of prognostic value among OC patients. This will facilitate to understand the underlying OC mechanisms and to implement targeted therapeutic measures.
Risk Factor Analysis of Clinical Outcomes of Total Aortic Arch Replacement and Frozen Elephant Trunk With Aortic Balloon Occlusion
Authors: Wang Luchen , Li Yunfeng , Dun Yaojun , Sun Xiaogang
Published: June 2021

Background: Total aortic arch replacement (TAR) with frozen elephant trunk (FET) requires hypothermic circulatory arrest (HCA) for 20 minutes, which increases the surgical risk. We invented an aortic balloon occlusion technique that requires 5 minutes of HCA on average to perform TAR with FET and investigated the possible merit of this new method in this study. Methods: This retrospective study included consecutive patients who underwent TAR and FET (consisting of 130 cases of aortic balloon occlusion group and 230 cases of conventional group) in Fuwai Hospital between August 2017 and February 2019. In addition to the postoperative complications, the alterations of blood routine tests, alanine transaminase (ALT) and aspartate transaminase (AST) during the in-hospital stay were also recorded. Results: The 30-day mortality rates were similar between the aortic balloon occlusion group (4.6%) and the conventional group (7.8%, P = 0.241). Multivariate analysis showed aortic balloon occlusion reduced postoperative acute kidney injury (23.1% vs 35.7%, P = 0.013) and hepatic injury (12.3% vs 27.8%, P = 0.001), and maintained similar cost to patients (25.5 vs 24.9 kUSD, P = 0.298). We also found that AST was high during intensive care unit (ICU) stay and recovered to normal before discharge, while ALT was not as high as AST in ICU but showed a rising tendency before discharge. The platelet count showed a rising tendency on postoperative day 3 and may exceed the preoperative value before discharge. Conclusions: The aortic balloon occlusion achieved the surgical goal of TAR with FET with an improved recovery process during the in-hospital stay.
Pseudoaneurysm With A Fistula To The Right Ventricle Late After Surgical Repair of Type A Aortic Dissection in A Patient with Systemic Lupus Erythematosus: A Case Report
Authors: Shimada Akie , Yamamoto Taira , Endo Daisuke , Nishida Kousuke , Matsushita Satoshi , Asai Tohru , Amano Atsushi
Published: June 2021

Background: Pseudoaneurysm with a shunt to the right ventricle after aortic repair for acute aortic dissection is an extremely rare and life-threatening condition. Surgical treatment is unavoidable, but surgery is complicated, and there are some pitfalls. Herein, we explain the reoperation procedure performed for a patient at high surgical risk by clarifying the shunt site using multi-modality imaging before surgery.Case presentation: A 69-year-old woman with a history of systemic lupus erythematosus (SLE) and Sjogren’s syndrome presented with a pseudoaneurysm 1 year after emergency surgery for acute type A aortic dissection. Eight years after the first operation, she experienced sudden chest pain and presented to the emergency department. Her dyspnea also worsened; therefore, echocardiography and three-dimensional computed tomography (3DCT) were performed, which revealed a pseudoaneurysm and a shunt to the right ventricle. The medical team attempted to close the shunt with a percutaneous catheter but was unsuccessful, and she was referred to our department for surgical treatment.The pseudoaneurysm originating from the proximal side of the aorta was large with a diameter of 55 mm, and echocardiography-gated 3DCT visualized the shunt from the pseudoaneurysm to the right ventricle. First, extracorporeal circulation was initiated, and a re-sternotomy was performed. We could not insert the left ventricular venting tube from the right side because of the size of the pseudoaneurysm; instead, the tube was inserted from the left atrial appendage. We found a half-circumferential disengaged anastomosis around the proximal anastomosis, which formed the large pseudoaneurysm leading to a fistula in the right ventricle. We closed the fistula and performed a Bentall operation.The patient had a good postoperative course and was discharged on postoperative day 21. She continued treatment for SLE and Sjogren’s syndrome and her inflammatory reaction improved.Conclusion: We performed a Bentall operation and closure of a fistula with a re-sternotomy in a patient with type A aortic dissection with systemic lupus erythematosus and Sjogren’s syndrome. Multimodal imaging is essential in defining the pseudoaneurysm and the fistula surrounding the anatomy while ensuring their resolution and guiding the approach for operation.
Association Between Cigarette Smoking Status And Voting Intentions: Cross Sectional Surveys In England 2015-2020
Authors: Cox Sharon , Brown Jamie , McQuire Cheryl , de Vocht Frank , Beard Emma , West Robert , Shahab Lion
Published: June 2021

Background and aims: Cigarette smoking takes place within a cultural and social context. Political views and practices are an important part of that context. To gain a better understanding of smoking, it may be helpful to understand its association with voting patterns as an expression of the political views and practices of the population who smoke. This study aimed to assess the association between cigarette smoking and voting intentions and to examine how far any association can be explained by sociodemographic factors and alcohol use.Methods: Pooled monthly representative repeat cross-sectional household surveys of adults (16+) in England (N = 55,482) between 2015-2020 were used to assess the association between cigarette smoking status and voting intentions, and whether this was accounted for by age, occupational grade, gender, region and alcohol use. Voting intention was measured by asking ‘How would you vote if there were a General Election tomorrow?’ Respondents chose from a list of the major English political parties or indicated their intention not to vote.Results: In adjusted multinomial regression, compared with intending to vote Conservative (majority party of government during the period), being undecided (aOR1.22 [1.13-1.33] <0.001), intending to vote Labour (aOR1.27 [1.16-1.36] <0.001), to vote “Other” (aOR1.54 [1.37-1.72] <0.001), or not to vote (aOR1.93 [1.77-2.11] <0.001) was associated with higher odds of current relative to never smoking rates. Intending to vote for the Liberal Democrats was associated with a significant lower odds of current smoking prevalence (aOR0.80 [0.70-0.91] <0.001) compared with intending to vote Conservative.Conclusions: Controlling for a range of other factors, current as compared with never-smokers appear more likely to intend not to vote, to be undecided, to vote for Labour or a non-mainstream party, and less likely to vote for the Liberal Democrats, compared with the Conservative party.
Dual Use of E-Cigarettes with Conventional Tobacco is Associated with Increased Sleep Latency
Authors: Alexander Laura Crotty , Advani Ira , Gunge Deepti , Boddu Shreyes , Mehta Sagar , Park Kenneth , Perera Samantha , Pham Josephine , Nilaad Sedtavut , Olay Jarod , Ma Lauren , Masso-Silva Jorge , Sun Xiaoying , Jain Sonia , Malhotra Atul
Published: June 2021

RationaleHealth effects of e-cigarettes remain relatively unknown, including impact on sleep quality. We previously showed in a pilot study that females who both smoke conventional tobacco and vape e-cigarettes (dual users) had decreased sleep quality and more difficulty falling asleep, suggesting an effect of gender. We undertook this study in a larger cohort to assess the impact of e-cigarette, conventional tobacco, and dual use on sleep quality, cough, and drug use.MethodsParticipants (n = 1198) were recruited through online surveys posted to social media sites with a monetary incentive. Participants were grouped by inhalant use, with 8% e-cigarette users, 12% conventional tobacco users, 30% dual users, and 51% non-smokers/non-vapers.ResultsDual use of e-cigarettes and conventional tobacco was associated with increased sleep latency relative to non-smokers/non-vapers (p = 0.012). Dual use was also associated with a higher reporting of cough (p = 0.034), as well as increased marijuana (p < 0.001) and cocaine usage (p < 0.001).DiscussionDual use is associated with longer sleep latency, suggesting that the shared component nicotine may be a driver. Because sleep broadly impacts multiple aspects of human health, defining the effects of e-cigarettes and vaping devices on sleep is critical to further our understanding of the effects of vaping on health.
MiR-195-5p Reduces Esophageal Cancer Cell Proliferation Through The IGF-1R/AKT Axis
Authors: Lin Zhao-xian , Lin Xing , Zhu Lihuan , Huang Jian-yuan , Huang Yang-yun
Published: June 2021

Background
Esophageal cancer (ECa) remains a major cause of mortality across the globe. The expression of MiR-195-5p is altered in a plethora of tumors, but its role in ECa development and progression are undefined.
Result
Here, we show that miR-195-5p is downregulated in ECa and associated with poor survival in ECa. Function assays indicated that MiR-195-5p inhibited ECa progression. Mechanistically, we identified IGF-1R as a downstream target of miR-195-5p, and miR-195-5p/IGFR axis caused a loss of GLUT1 expression, reduced glucose uptake, reduced lactate production, and low levels of ATP production.
Conclusion
Collectively, miR-195-5p as a Eca suppressor impaired glycolysis. This highlighting miR-195-5p as a novel target for much needed anti-ECa therapeutics.
Sexual quality of life in young women with breast cancer during adjuvant endocrine therapy: objective assessment and patient-reported supportive measures.
Authors: Bobrie Angelique , Jarlier Marta , Moussion Aurore , Jacot William , D'Hondt Veronique
Published: June 2021

Purpose: sexual quality of life (QoL) is affected during and after breast cancer (BC) treatment. Young women are more frequently and severely affected. We analyzed the sexual and global QoL in less than 51 years old women with BC receiving adjuvant endocrine therapy for at least 2 years, to analyze sexual dysfunction after the acute treatment phase. We also questioned women on the actions taken individually and on those they would find useful to address these issues.Methods: a prospective study was conducted to evaluate the sexual QoL of young women with BC during the adjuvant endocrine treatment and to assess patient-reported supportive measures.Results: a total of 45 women completed the 3 EORTC questionnaires and an additional specific questionnaire proposed in the context of the study. We showed a deterioration of the sexual QoL and a poor communication with healthcare professionals about this issue. Most patients (88.9%) declared important that sexuality should be discussed with caregivers and that the partner should be involved in the discussion. The majority of patients (60%) had taken at least one action to overcome the sexual problems, in order of frequency: local treatment like vaginal moisturizer, consultation with a psychologist, while a consultation with a sexologist remained rare. Most of these interventions (63%) originated from the patient herself. Conclusion: sexual QoL is a major issue in BC patients less than 51 years old during endocrine treatment. Communication on sexuality with healthcare professionals needs to be improved. Most of the supportive methods used by the patients were at their own initiative, highlighting the need for a professional counseling on this topic. Finally, patients suggested supportive measures they would find useful and appropriate to develop in clinic.NCT 04200001
Characteristics and Influencing Factors of Energy Consumption in Chinese Rural Households
Authors: Ma Xiaowei , Liu Dandan , Chen Danni , Wang Mei , Li Chuandong
Published: June 2021

The sustainable development of China's economy has brought about a large increase in energy consumption of residents, especially in rural areas. Nowadays, the per capita energy consumption in rural areas has exceeded the urban residents. Therefore, it is of great significance to pay attention to the energy consumption of rural households in order to realize the harmonious development of energy and economy in China. Based on the survey data of rural households in central and eastern China, this paper uses the method of CLAD estimation of Tobit model to study the influencing factors and structural characteristics of rural households' energy consumption, so as to analyze how to deal with the rapid growth of rural energy consumption and optimize the rural energy structure. The results show that the energy structure of rural households is unreasonable, rural families are using more traditional and inferior cooking heating energy, and there are some differences in different regions; Family characteristics, family wealth and energy conservation initiative have an impact on total energy consumption and different types of energy. Increasing income, education level, electrical appliances quantity and energy conservation initiative are conducive to optimizing the energy structure of the family and promoting the transformation of energy structure.
Assessing The Performance Characteristics of Handheld Ultrasound in A Rheumatic Heart Disease Screening Program
Authors: Kaltenborn Zachary P. , Anteneh Zewde. , Kirsch Jonathan D. , Yates Michelle , Tessier Katelyn M. , Nemec Eileen , Johannsen Ronald A.
Published: June 2021

Background
Rheumatic heart disease affects 33 million people in low and middle income countries and is the leading cause of cardiovascular death among children and young adults. Penicillin prophylaxis has been shown to improve valvular function among patients with clinically silent or mild disease. Efforts to expand echocardiographic screening are focusing on simplified protocols, non-physician ultrasonographers, and portable ultrasound devices, including handheld ultrasound. Recent advances support the use of single-view screening protocols. With the increasing availability and low cost of handheld devices, prospective studies are needed to evaluate their performance in these settings.
Methods
We conducted a cross-sectional study among 19 at-risk school-children participating in a rheumatic heart disease screening program in Ethiopia comparing a handheld ultrasound device (Phillips Lumify) to a fully-equipped portable ultrasound machine (Sonosite M-Turbo).
Results
Agreement between devices was similar for expert and non-expert review (84%). However, when reviewed by a non-expert the Lumify identified fewer screen-positive cases (p-value 0.083). We also compared non-expert to expert interpretation by device and found a significant difference in interpretation for the Lumify (p-value 0.025). There was a trend towards shorter jet length by color Doppler in the handheld ultrasound device for both expert and non-expert review.
Conclusions
Our study highlights the importance of using caution when applying proposed single-view criteria as the sensitivity and specificity may be affected by the device.
Comprehensive Analysis of Prognostic and Immune Infiltrates for CBX Family in Human Pancreatic Adenocarcinoma
Authors: li qian , fu lei , wu Dao yuan , wang feng ju
Published: June 2021

Background: Pancreatic adenocarcinoma (PAAD) is one of the common Malignant tumours of the digestive tract worldwide. Chromobox (CBX) family proteins are important components of epigenetic regulation complexes and play key roles in various biological processes. However, the expression level, biological function and immune infiltration of different E2Fs in PAAD and prognostic roles of various CBX family members in Pancreatic adenocarcinoma (PAAD) remain unclear.Methods: In this study, we used multiple bioinformatics tools including Oncomine, GEPIA, Kaplan-Meier plotter, cBioPortal, GeneMANIA, TIMER and R Tools to analyze expression levels, prognostic value, genetic alteration, immune cell infiltration and risk factors of CBXs in Pancreatic adenocarcinoma patients. Furthermore, we confirmed the expression of CBX3 on clinic pathological specimens by immunohistochemistry.Results: The expression levels of CBX1/3/5/8 were significantly elevated in PAAD tissues, and the high expression of CBX1/5/6/7 was associated with the tumor stage of patients. Higher mRNA expression of CBX2/6/7 and CBX8 were significantly associated with favorable OS of pancreatic cancer patients, while higher expression of CBX3 was significantly associated with short OS. We verified the high expression of CBX3 in pancreatic cancer tissues on clinicopathological specimens. Multivariate logistic analysis demonstrated that high mRNA expressions of CBX3 and low expression of CBX8 were independent risk factors for shorter survival of pancreatic carcinoma patients. The functions of CBXs and its neighboring proteins are mainly related to negative regulation of cell cycle process, PcG protein complex, histone binding and regulating pluripotency of stem cells signaling pathways. We also found that the expression of CBXs was significantly correlated with immune infiltrates.Conclusions: Our study may provide new insights into the selection of immunotherapeutic targets and prognostic biomarkers and revealed that CBX3/8 may represent a clinically useful biomarker for predicting overall survival in patients with PAAD.