bluuebunny/crossref_metadata_2025 huggingface dataset:
Right frontal lobe AVM rupture with the formation of an intraparenchymal hematoma of the medial sections of the right fronto-parietal region and the corpus callosum. Clinical case of staged treatment and literature review
Authors:   Federal State Autonomous Educational Institution of Higher Education «Peoples' Friendship University of Russia», Medical Institute, Department of Nervous Diseases and Neurosurgery, Moscow, Zokhidov Z. U. ,   Morozov Children's City Clinical Hospital of the Moscow Healthcare Department, Center for Treatment of Cerebrovascular Pathology in Children and Adolescents, Moscow, Chmutin G. E. ,   Federal State Autonomous Educational Institution of Higher Education «Peoples' Friendship University of Russia», Medical Institute, Department of Nervous Diseases and Neurosurgery, Moscow; Morozov Children's City Clinical Hospital of the Moscow Healthcare Department, Center for Treatment of Cerebrovascular Pathology in Children and Adolescents, Moscow, Livshitz M. I. ,   Federal State Autonomous Educational Institution of Higher Education «Peoples' Friendship University of Russia», Medical Institute, Department of Nervous Diseases and Neurosurgery, Moscow; Morozov Children's City Clinical Hospital of the Moscow Healthcare Department, Center for Treatment of Cerebrovascular Pathology in Children and Adolescents, Moscow, Levov A. V. ,   Morozov Children's City Clinical Hospital of the Moscow Healthcare Department, Center for Treatment of Cerebrovascular Pathology in Children and Adolescents, Moscow, Shchederkina I. O. ,   Morozov Children's City Clinical Hospital of the Moscow Healthcare Department, Center for Treatment of Cerebrovascular Pathology in Children and Adolescents, Moscow, Oleynikov B. I. ,   Federal State Autonomous Educational Institution of Higher Education «Peoples' Friendship University of Russia», Medical Institute, Department of Nervous Diseases and Neurosurgery, Moscow; Morozov Children's City Clinical Hospital of the Moscow Healthcare Department, Center for Treatment of Cerebrovascular Pathology in Children and Adolescents, Moscow
Published: August 2022

In the article, we report on a case of a 13‑year-old teenager with a verified intracranial hemorrhage resulting from an arteriovenous malformation (AVM) rupture in the right frontal lobe. Staged combined surgical treatment was carried out. The article discusses the features of diagnosis and tactics of surgical treatment of children with arteriovenous malformations in the acute and subacute periods of intracranial hemorrhage (ICH). Purpose of the study: Presentation and assessment of a clinical case and the combined treatment of the spontaneously ruptured AVM of the medial parts of the right frontal lobe with the formation of intracerebral hematoma of the medial parts of the fronto-parietal region and the corpus callosum in the ICH acute and subacute periods.
Presentation of sustainability-related information on governance and strategy to users of financial reporting
Authors:   Federal State Autonomous Educational Institution of Higher Education “Lobachevsky State University of Nizhni Novgorod”, Nizhny Novgorod, Russia, Druzhilovskaya E.S.
Published: August 2022

Currently, many Russian organizations disclose sustainability-related information (and healthcare organizations are no exception). In this regard, it is very relevant today to study the regulations of the draft International Financial Reporting Standard IFRS S1 “General requirements for disclosure of sustainability-related financial information” (hereinafter — the draft IFRS S1). This document is aimed at developing uniform regulations for the presentation by organizations to users of their financial reporting of sustainability-related financial information. Such information, according to the this project, should include data on 1) governance, 2) strategy, 3) risk management, 4) metrics and targets. The regulations of the draft IFRS S1 regarding the provision of sustainability-related information on the first two components — on governance and strategy — are analyzed by us in this article. The rules of this document regarding the disclosure of information about the other two components — risk management and metrics and targets — will be explored by us in the next article. During the research, such methods as analysis and synthesis, grouping method, comparison, analogy method, systematic approach, logical approach were used. As a result of the research, this article presents proposals for solving problems arising from the regulations of the draft IFRS S1 in relation to the presentation of sustainability-related information on governance and strategy to users of financial reporting.
The status and ways to improve the accounting for staff salariesat JSC “VRM”
Authors:   Federal State Budgetary Educational Institution of Higher Education “Voronezh State Agrarian University named after Emperor Peter the Great”, Ministry of Agriculture, Voronezh, Russia, Leonova O.I. , Malitskaya V.B. ,   Federal State Budgetary Educational Institution of Higher Education “Russian Economic University named after G. Plekhanov”, Ministry of Science and Education of the Russian Federation, Moscow, Russia, Prodanova N.A. ,   Federal State Budgetary Educational Institution of Higher Education “Russian Economic University named after G. Plekhanov”, Ministry of Science and Education of the Russian Federation, Moscow, Russia
Published: August 2022

The article discusses the state and ways to improve the accounting for staff salaries on the example of JSC “VRM”. Accounting for staff salaries requires the development and approval of a number of internal documents of the company: staff register; forms of scource accounting documentation; collective employment agreement; internal labor regulations and a number of bylaws. This article systematizes the bylaws applied at JSC “VRM” and specifies the collective employment agreement. The authors define the procedure for the creation and the main responsibilities of the working group, and propose documents for implementation on which the efficiency and optimization of the accounting process of salaries payable depend.
Tax risks of retraining civil law relations with self-employed citizens into labor
Authors:   Institute of Law and Management, Moscow City University, Shinkareva O.V. , Agafonov D.S. ,   Moscow City University of Management of the Government of Moscow named after Yu.M. Luzhkov
Published: August 2022

Many health care institutions, primarily private ones, are increasingly attracting professional income tax payers in their activities, drawing up civil law contracts with them. At the same time, this type of contracts is often used by unscrupulous taxpayers to avoid paying mandatory payments, in connection with which the tax authorities pay special attention to the control of these contracts. The article considers the differences between the employment contract and the civil law contract, lists the signs of substitution by the civil law contract with the payer of the tax on the professional income of the employment contract, used by the tax authorities when retraining relations with an individual into labor.
The legal environment for the execution of a state contract: a note to the accountant
Authors:   Plekhanov Russian University of Economics, Lebedev V.A. , Lebedeva E.I. ,   Non-profit Partnership “Institute of Professional Accountants and Auditors of Russia”
Published: August 2022

The current legislation regulating the execution of the state contract, as well as the relevant law enforcement practice on examples related to the procedure for the execution of the state contract, its modification and termination are considered. The analysis of legal means ensuring the legality and effectiveness of contract procedures, the stability of the contract system in the face of unforeseen circumstances, as well as the very concept of force majeure as an extraordinary and unavoidable circumstance. The operational measures proposed by the legislator to respond to the relevant circumstances in the process of executing state contracts, including measures to ensure the interests of the parties to the state contract, are considered.
Reflection of the life cycle of an intangible asset in the accounting of a budgetary institution of the agro-industrial complex
Authors:   Federal State Budgetary Educational Institution of Higher Education «Moscow Aviation Institute (NIU)», Moscow, Russia, Vlasova O. M. , Gorelov B. B. ,   Federal State Budgetary Educational Institution of Higher Education «Moscow Aviation Institute (NIU)», Moscow, Russia, Korzhueva L. M. ,   Federal State Budgetary Educational Institution of Higher Education «Moscow Aviation Institute (NIU)», Moscow, Russia, Postnikova L. V. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — K.A. Timiryazev Agricultural Academy», Moscow, Russia
Published: August 2022

The development of accounting in the public sector of the agro-industrial complex has significantly affected the accounting of intangible assets. With the application of the Standard, the approach to accounting for intangible assets has changed, now it is based on the principles of IFRS, therefore, intangible assets themselves can be presented from a different point of view. The authors of the article attempt to consider intangible assets as a life cycle model, which has not yet been applied to the concept of intangible assets. The algorithm of managerial decision-making and accounting of intangible assets at each stage of its life cycle is also proposed.
Educación en valores: empatía y tolerancia en las aulas universitarias
Authors: Mendieta Toledo Lenin Rijkaard , Manosalvas Durán Fernanda Elizabeth , Barco Romero Rosa Mireya
Published: July 2022

La tolerancia y la empatía son valores fundamentales en la sociedad y en la práctica docente. Ambos conceptos han existido desde hace muchos años y han ido conmutando con el paso del tiempo, son base fundamental de las relaciones humanas e interpersonales. Sin embargo, por alguna razón, los docentes no siempre han puesto en práctica estas dos cualidades en sus educandos. Se realizaron revisiones bibliográficas para comprender e interpretar la importancia que tienen la tolerancia y la empatía dentro del aula de clase, valores que cuando son puestos en práctica mejoran el ambiente áulico y por ende la formación de los alumnos para su posterior práctica profesional.
Amor y respeto en la práctica docente universitaria
Authors: Moran González David Renato , Vélez Yunga Liliana Mery , Anchundia Gómez Oscar Efrén
Published: July 2022

Tratamos acerca del Amor el respeto y su vinculación en la práctica docente universitaria; con el objetivo de analizar la importancia y efectos en la docencia universitaria; nos adentramos en el amor entramado con el respeto, miramos que la educación ha cambiado, la era digital nos visita cada día con cambios inesperados que han hecho del ser humano, dependiente de dicha era. El perfil docente debe basarse en valores que le permitan desempeñarse como persona y profesional, entendemos al amor como uno de los pilares más profundos del ser humano que nos permite convivir en armonía. El docente debe tener manifestaciones de amor y respeto, valores que nos ilusionan que podemos coexistir con libertad y límites, con amor y respeto. Alimentamos estos valores para crecer en sentimientos en los territorios de una docencia universitaria pintada en sutiles pinceladas de amor y respeto, desde nuestra vera docente nos comprometemos a que estos valores se impartan en este ámbito.
Congresso Brasileiro de Investigação e Reabilitação Neurológica - COBREN II
Authors: Favero Francis
Published: August 2022

O II Congresso Brasileiro de Investigação e Reabilitação Neurológica (COBREN) teve como objetivo discutir novas atualizações e perspectivas de cunho investigativo científico, foram apresentados trabalhos inovadores. Destinado a reunir todos os pesquisadores, com o objetivo de trocar informações sobre vários aspectos das funções e disfunções neurológicas, principalmente quanto às formas de avaliação, terapêuticas e tecnologias.
Safety and Efficacy of Patiromer in Hyperkalemic Patients with CKD: A Pooled Analysis of Three Randomized Trials
Authors: Haller Hermann , Bianchi Stefano , McCafferty Kieran , Arthur Susan , Quinn Carol Moreno , Budden Jeffery , Weir Matthew R.
Published: August 2022

Key Points

Hyperkalemia is frequently observed in patients with CKD, and its frequency and severity increase as CKD progresses.

Patiromer is an effective and well-tolerated treatment option for hyperkalemia in patients with advanced or mild/ moderate CKD on RAASi.

Background

Hyperkalemia is a common electrolyte abnormality in patients with CKD, which is associated with worse outcomes and limits use of renin–angiotensin–aldosterone system inhibitors (RAASi). This post hoc subgroup analysis of three clinical trials evaluated the efficacy and safety of the sodium-free, potassium-binding polymer, patiromer, for the treatment of hyperkalemia in adults with nondialysis CKD.

Methods

Data from the 4-week treatment periods of AMETHYST-DN, OPAL-HK, and TOURMALINE studies were combined. Patients had baseline diagnosis of CKD, hyperkalemia (serum potassium >5.0 mEq/L), and received patiromer 8.4–33.6 g/day. Patients were stratified by baseline eGFR into two subgroups: severe/end-stage CKD (stage 3b–5; eGFR <45 ml/min per 1.73 m2) and mild/moderate CKD (stage 1–3a; eGFR ≥45 ml/min per 1.73 m2). Efficacy was assessed by the change in serum potassium (mean±SE) from baseline to week 4. Safety assessments included incidence and severity of adverse events (AEs).

Results

Efficacy analyses (n=626; 62% male, mean age 66 years) included 417 (67%) patients with severe/end-stage CKD and 209 (33%) with mild/moderate CKD. Most patients were receiving RAASi therapy at baseline (severe/end-stage CKD 92%; mild/moderate CKD 98%). The mean±SE change in serum potassium (baseline to week 4) was −0.84±0.03 in the severe/end-stage CKD subgroup, and −0.60±0.04 mEq/L in the mild/moderate CKD subgroup. AEs were reported for 40% and 27% patients in the severe/end-stage and mild/moderate CKD subgroups, respectively, with 16% and 12% reporting AEs considered related to patiromer. The most frequent AEs were mild-to-moderate constipation (8% and 3%) and diarrhea (4% and 2%). AEs leading to patiromer discontinuation occurred in 6% and 2% of patients with severe/end-stage CKD, and mild/moderate CKD, respectively.

Conclusions

Patiromer was effective for treatment of hyperkalemia and well tolerated in patients across stages of CKD, most of whom were receiving guideline-recommended RAASi therapy.
A Fronteira Sul e as andanças do Cacique Doble entre Rio Grande do Sul e Santa Catarina (1852-1864)
Authors: Souza Almir Antonio de , Lino Jaisson Teixeira , Araújo Fábio
Published: August 2022

O presente artigo se insere no campo da história indígena e toma por recorte temporal o século XIX, e o amplo território denominado Fronteira Sul pelas fontes históricas utilizadas no estudo. No texto buscamos investigar parte da trajetória de um personagem histórico, a liderança indígena Kaingang CaciqueDoble, cuja atuação desenvolveu-se no período e no cenário mencionados. Ao olhar para a trajetória de Doble, também observarmos as relações que essa liderança manteve com os não-indígenas, agentes colonizadores, e também com os próprios indígenas na luta pela manutenção de seu território tradicional.Os deslocamentos de Doble pelo território Kaingang, as relações de naturezas políticas e diplomáticas com indígenas e não-indígenas, observados através das fontes históricas, nos sugerem uma compreensão mais ampla sobre o conceito de fronteira que, no caso particular de Doble, se revelou uma fronteira muitodinâmica, um local de encontro entre diferentes, posto de comunicação e trocas diversas entre os diversos agentes.
Reseña de: Por qué el derecho es violento (y debería reconocerlo), Buenos Aires, Siglo XXI de Christoph Menke (2020)
Authors: Lanza Melina
Published: August 2022

En este libro, el autor, nos ofrece sus reflexiones acerca de la contradicción entre derecho y violencia. La reseña se basa en la traducción que nos ofrece Miguel Guadrón Ramírez que además posee un estudio introductorio con dos variaciones Latinoamericanas sobre por qué el derecho es violento.
De levo a pueblo, la evolución sociopolítica y demográfica de los mapuche de Concepción: los coyunche y sus transformaciones en el marco de la encomienda de Alonso Galiano, 1550-1700
Authors: Stewart Daniel , Zavala Jose Manuel
Published: August 2022

Antes de la llegada de los españoles a la región de Concepción, sus habitantes estaban organizados en agrupaciones socio-territoriales: los levo o rewe que se articulaban, en algunos casos, en alianzas mayores reconocidas posteriormente bajo la denominación de ayllarewe. Una de estas alianzas era la de los denominados coyunche de los llanos ribereños del río Laja. Con la presencia española los coyunche sufrieron una ruptura, los levo de más al norte quedaron bajo dominio español mientras que los del de más al sur se mantuvieron en una relativa independencia. Este trabajo presenta la evolución de los coyunche nortinos que fueron sometidos tempranamente al régimen de encomienda y analiza los cambios y vicisitudes que vivieron durante un siglo y medio de historia en el marco de este régimen de trabajo.
Motorized Leg Length Discrepancy Measure: A New Device for Clinical Use – A Cross-sectional Study
Authors: Salekzamani Yaghoub , Abolghassemi Fakhree Nargess , Ebrahimi Afshin , Heravi Hamed , Dolatkhah Neda
Published: August 2022

Objectives: This study aimed to construct a device that could measure leg length discrepancy (LLD) automatically. Materials and Methods: The LLD measure device measures LLD with pelvic-tilt method (Program 1) and weight-based method (Programs 2 & 3). Tests were done in 3 phases. 1: Two examiners using the LLD Measure device made -50 to 75 mm artificial LLD in two healthy subjects measuring the degree of pelvic tilt and the load bearing of lower limbs. 2: Sixteen healthy volunteers were asked to stand on the device to measure LLD with program 2 and then with both knees extended to measure LLD with program one. 3: 32 patients who had underwent lower limbs CT scanogram enrolled, and the LLD measurement with program 1 compared with those obtained by CT scanogram. Results: Data’s obtained in the first phase showed excellent repeatability (intra-class correlation coefficient [ICC] > 0.9) and very good reproducibility (ICC > 80%) except for measuring the limb load while both knees were extended (ICC ≈ 60%). In the second phase, we found no statistically significant difference between measuring LLD using programs 1 and 2 (P = 0.49). In the third phase, there was no statistically significant difference between measuring LLD using program 1 and CT scanogram (P = 0.80). Conclusions: We have developed a device to measure LLD semiautomatic with less need for examiner expertise. The results of our new device would be reliable and accurate compared to CT measurements.
Structural Equation Modelling of Primary and Secondary Vulnerability of Psychopathic Disorder based on Behavioral Brain Systems in Medical Students
Authors: Deljou Bahareh , Bakhshipour Rudsari Abbas , Farnam Alireza
Published: August 2022

Background. The level of activity of behavioral brain systems is one of the effective factors in the occurrence or persistence psychopathic behaviors. Therefore, the aim of this study was to structurally model primary and secondary psychopathic disorder based on behavioral brain systems. Methods. This research is applied in terms of purpose and descriptive in terms of correlational research method. The statistical population of this study includes all medical students of Tabriz University of Medical Sciences. A total of 284 subjects were selected as a sample by convenience sampling method and they performed Lonson, Kiel and Fetispatrick Psychopathy Scale and the Carver and White Brain-Behavioral Systems Scale. Data were analyzed using Pearson correlation coefficient and structural equation modelling with SPSS software version 24 and LISREL version 8.80. Results. The results showed that the behavioral activation system has a positive and significant relationship with primary and secondary psychopathy and the behavioral inhibition system has a negative and significant relationship with primary and secondary psychopathy (P <0.01). The results of structural equation model showed that behavioral activator system and behavioral inhibition system have an effective role on primary and secondary psychopathy (P <0.01). Also, the results of structural equation model showed acceptable model (2/df= 2.50, RMSEA= 0.075, CFI= 0.96, NFI= 0.94, GFI= 0.94). Conclusion. According to the function of activating systems and behavioral inhibition, pathological personality traits can be oriented or corrected before the formation and stabilization of these traits.
Electrochemical Sensing Platform Based on The Modified Carbon-Ceramic Electrode Using Multiwalled Carbon Nanotubes (MWCNTs) Through The Sol-Gel Process: Application in Sensitive Determination of Morin as A Common Flavonoids
Authors: Mehdipour Sima , Majidi Mir Reza , Asadpour-Zeynali Karim , Sohrabi Hessamaddin
Published: August 2022

Morin is one of the most common flavonoids which found in nature, plants and vegetable-derived foods and Brazilian yellow tree is a source for its extraction. Because of hydroxyl group existence, Morin represents better antioxidant properties and have great significance in bio electrochemistry-based investigations. In this research work, an electrochemical-based sensing platform was designed based on a modified carbon-ceramic electrode (CCE) through a sol-gel process with carbon nanotubes for the investigation of the electrochemical behavior of Morin. Various electrochemical techniques have been used for the analytical investigation of the proposed sensing platform including cyclic voltammetry (CV), differential pulse voltammetry (DPV), and anodic stripping voltammetry (ASV) methods. Furthermore, the morphological investigation was efficiently performed for the demonstration of electrode surface characteristics. The obtained results showed that the anodic peak currents increased linearly in a concentration range of 0.7– 3 µM, where detection limit is equal to 0.27 µM for DPV, and the linear range is considered to be 0.6-4 µM where there is a lower detection limit of 0.3 µM for ASV. Such a biosensing assay can also prove a great potential for the determination of Morin in dry tea.
Comparison of superior airway dimensions and cephalometric anatomic landmarks between 8–12-year-old children with obstructive sleep apnea and healthy children using CBCT images
Authors: Emsaeili Farzad , Sadrhaghighi Amirhouman , Sadeghi-Shabestari Mahnaz , Nastarin Parastou , Niknafs Aliakbar
Published: August 2022

Background. The etiology of obstructive sleep apnea (OSA) syndrome in children significantly differs from adults. In previous studies, only some of the indices have been investigated using CBCT. This study compares all the measurable indices of airway dimensions and anatomical cephalometric landmarks between children with OSA and healthy ones using cone-beam computed tomography (CBCT). Methods. Dimensions of the airway and cephalometric values were measured on CBCT scans of 50 children aged 8–12 (25 patients with OSA and 25 healthy subjects) and then compared between the two groups. The results of this study were analyzed with independent t test using SPSS 17 at a significance level of P<0.05. Results. Area, length, volume, anteroposterior length, and size of the upper airway in subjects with OSA were lower than those in healthy children, while the average values of SNA, SNB, and ANB in the OSA group were higher than those in the healthy group (P=0.366, P=0.012, and P=0.114, respectively). Also, BaSN, PNS/AD1, and PNS/AD2 measurements in subjects with OSA were lower than healthy subjects (P=0.041, P=0.913, and P=0.015, respectively). In addition, the width and anteroposterior length of the upper airway, SNB, BaSN, PNS/AD1, and PNS/AD2 indices were significantly different between the healthy group and those with OSA (P<0.05). Conclusion. Reduced upper airway dimensions, adenoid tissue enlargement, and cranial base flexion might play an important role in OSA development in children. However, most skeletal variables, such as the anteroposterior relationship of jaws and jaw rotation, were not significantly different between the two groups.
Management of skeletal Cl III malocclusion using simultaneous alternate rapid maxillary expansion and constriction (Alt-RAMEC) and facemask protraction in adolescence
Authors: Singh Harpreet , Kapoor Pranav , Sharma Poonam , Maurya Raj Kumar , Mittal Tanmay
Published: August 2022

Cl III malocclusion with a significant skeletal component presents a therapeutic challenge during adolescence. This article presents the encouraging results of an individualized two-stage treatment approach adopted for successful nonsurgical correction of severe skeletal Cl III malocclusion in an adolescent girl after the onset of puberty. An orthopedic approach involving simultaneous alternate rapid maxillary expansion and constriction (Alt-RAMEC) protocol and protraction facemask (PFM) therapy was adopted in phase 1 to correct the sagittal skeletal discrepancy. In phase 2, fixed orthodontic therapy aided by the interim use of a modified occlusal settling appliance was undertaken to obtain well-interdigitated occlusion. Meticulously planned and well-executed orthopedic and orthodontic approach, combined with good patient compliance and favorable growth pattern, helped establish well-balanced facial harmony with a proper maxillomandibular relationship and satisfactory overjet and overbite. The results remained stable during the 4-year follow-up. Alt-RAMEC-PFM therapy accompanied by fixed mechanotherapy is a viable option to treat severe skeletal Cl III malocclusion in adolescents.
The assessment of functional indices of left ventricular wall layers in cases with normal and high blood pressure by layer-specific strain methods
Authors: Toufan Tabrizi Mehrnoosh , Khezerlu Naser , Shahabi Rabori Venus , Heidari Sarvestani Ali
Published: August 2022

Introduction: The arterial hypertension leading to left ventricular remodeling induces accentuated ventricular wall thickness because of higher afterload. The several surveys about myocardial function in such cases were conducted by imaging studies for the evaluation of myocardial wall thickness without separating the different layers of each other. The aim of this investigation was the evaluation of the functional indices of each layer of the left ventricular myocardium by staining analysis of layers and demonstration of the relationship between ventricular structural remodeling and the functional changes of the ventricle myocardial layers in persons with normal and high blood pressure. Methods: 88 cases (46.6% normotensive and 53.4% hypertensive) were studied by two-dimensional echocardiography and longitudinal and circumferential strain indices. These differentiated variables of heart layers (epicardium, mid myocardium, endocardium) were evaluated. All of them had been analyzed and compared in terms of diastolic dysfunction were compared. Normal diastolic function was defined as: E/A=1 to 2 and deceleration time=150 to 200 ms. Results: Global longitudinal strain (GLS) and global circumferential strain (GCS) strains remarkably declined in epicardial and middle layers of myocardial in hypertensive cases with diastolic dysfunction, although this alternation did not reveal in cases without diastolic dysfunction. Conclusion: The decreasing of GLS and GCS indices of mid-myocardial and epicardial layers have been predicted in cases with high pressure, and the evidences of this situation had been observed in cases with ventricular diastolic dysfunction.
Association of two high-risk strains of human papillomavirus (HPV18 and HPV16) with breast cancer in the patients using polymerase chain reaction
Authors: Ghaderi Loghman , Montazer Majid , Naseri Ali Reza
Published: August 2022

Introduction: Two high-risk strains of human papillomavirus (HPV18 and HPV16) immortalize human mammary epithelial cells and reduce their growth factor requirements. Recent studies have identified HPV in a broad range of breast cancer samples. Therefore, the study aimed to assess the association of the mentioned high-risk HPV strains (HPV18, HPV16) with breast cancer in the patients using polymerase chain reaction (PCR) due to the increasing prevalence of breast cancer. Methods: The current work was a retrospective study involving 60 participants (40 patients with breast cancer and 20 healthy people) at Tabriz University of Medical Sciences in 2018-2019. The participants were selected using a convenience sampling method. PCR was used to detect DNA genomes of HPV18 and HPV16. Data was analyzed using Phi and Cramér’s V with SPSS v. 21 by taking into account OR=95% and P=0.05. Results: There was a significant relationship (P value=0.014) between HPV18 and HPV16 infection and breast cancer. Conclusion: A significant relationship was found between the presence of DNA genomes of HPV16 and HPV18 and breast cancer. Therefore, HPV has a significant role in breast cancer.
Synergistic effect of copper oxide nanoparticles and chloramphenicol antibiotic on MexA gene expression of pump efflux system in drug-resistant Pseudomonas aeruginosa isolates
Authors: Alazavi Faten , Molavi Farahnaz - , Tehranipoor Maryam
Published: August 2022

Background. Pseudomonas aeruginosa is a causative agent of nosocomial infections. Chloramphenicol is a broad-spectrum, inexpensive, and common antibiotic. MexAB-OprM is a secretory pump that causes the innate resistance of this bacterium. This study aimed to evaluate the expression of MexA gene under the treatment of copper nanoparticles and chloramphenicol. Methods. In this study, 49 samples were collected from 11 laboratories in Mashhad, Iran.Abundance of Me gene MexA was done by polymerase chain reaction (PCR) method, and antibiotic susceptibility assessment was performed by disk diffusion method. To calculate minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), copper nanoparticles, and a combination of both, the broth dilution method was performed. Microdilution method and real time PCR technique were used to determine the effective dilution of copper oxide nanoparticles and chloramphenicol antibiotics and expression of MexA gene, respectively. Result. The identity of 49 strains was confirmed. All strains had the MexA gene and were resistant to more than two antibiotics. The MIC of bacterial strains was 250 μg/ml for copper oxide nanoparticles and 62.50 μg/ml for chloramphenicol antibiotic. Compared to antibiotics, copper nanoparticles had a greater effect on MIC, though it was lower than the combined effect of antibiotics and copper oxide nanoparticles. Conclusion. Copper oxide nanoparticles or the synergistic effect of copper oxide nanoparticles and chloramphenicol antibiotics are effective in reducing MexA gene expression. Practical Implications. Nanoparticles are an important option for use as an alternative to or supplement to antibiotics. Also, copper oxide nanoparticles are more effective to inhibit bacterial growth when used in combination with antibiotics.
The effectiveness of family-centered play therapy on reducing children's behavioral problems
Authors: Mahmoodi Sima , Mohammadpanah Azra , Chobforoshzadeh Azadeh , Faroughi Paria
Published: August 2022

Background. Childhood is one of the most important stages of life in which a person's personality is established and formed. Most post-childhood behavioral disorders and maladaptations are due to a lack of attention to a sensitive childhood and a lack of proper guidance in the developmental process. This negligence leads to incompatibility with the environment and the occurrence of various deviations in different dimensions for the child. The present study was conducted to determine the effectiveness of play-based family therapy on reducing behavioral problems in children in Ardakan, Iran. Methods. This quasi-experimental research had a pre-test-post-test design with experimental and control groups and random replacement. The statistical population included all children with behavioral problems aged 7-11 years who were studying in Ardakan city in 2018-2019 academic year. Using purposive sampling method, 30 subjects were selected and randomly assigned into the control and experimental groups. The experimental group received a family-centered play therapy program for nine sessions, while the control group received no intervention. The research tool included a demographic questionnaire and a Children's Behavioral Checklist (CBCL), which was provided to parents. Research data were analyzed using univariate analysis of covariance (ANCOVA). Results. The results of data analysis showed that the family-centered play therapy training program improved children's behavioral problems, aggression, lawlessness, isolation, anxiety, and depression in the experimental group.(P<0.01) No significant change was observed in the control group. Conclusion. Family-centered play therapy can be an effective method in improving behavioral problems in children. Practical implications. Therapists can use family-centered play therapy in the process of treating children's behavioral problems as one of the effective methods in reducing symptoms.
The Role of Andrographis paniculata in Modulating the Immune Response in Cancer-Associated Chronic Inflammation, Angiogenesis, and Metastasis
Authors: Ulvia Rengganis , Gani Andayana Puspitasari , Murwanti Retno
Published: August 2022

The immune system plays an essential role in cancer pathogenesis through providing an inflammatory immune response. Chronic inflammation causes tumor growth, angiogenesis, and metastasis facilitated by interactions between tumor, immune, and stromal cells in the tumor microenvironment (TME). Various inflammatory mediators and growth factors secreted by cells in the TME exert a synergistic effect on cancer promotion. Thus, the development of cancer therapies that lead to inhibition of the activity of immune cells, cytokines, chemokines, and cancer-inducing growth factors is a promising therapeutic strategy. Andrographis paniculata (A. paniculata) is an ethnomedicinal plant with immunomodulatory and anticancer activity. A. paniculata can also inhibit the resistance of chemotherapy agents associated with the TME as adjuvant chemotherapy. This review focuses on the mechanism of A. paniculata in suppressing cancer-associated chronic inflammation, angiogenesis, and metastasis through modulation of the immune response. The results show that A. paniculata exerts anticancer effects directly targeting cancer cells, inhibiting cancer growth by modulating immune responses. A. paniculata exerts anticancer effects by inhibiting the production of cytokines, growth factors, and chemokines via the nuclear factor-kappa B (NF-ĸB), mitogen-activated protein kinase (MAPK), Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways. In addition, this review provides a new hypothesis regarding the potential of A. paniculata to serve as an anticancer agent that can inhibit cancer cell proliferation at the angiogenesis and metastatic stages through regulating inflammation due to interactions between cancer cells, immune cells, and stromal cells in the TME.
mir-451a-5p Modulates Breast Cancer Cell Apoptosis, Migration, and Chemosensitivity to Carboplatin through the PTEN Pathway
Authors: Khordadmehr Monireh , Ezzati Hamed , Shahbazfar Amirali , Jigari-Asl Farinaz , Baradaran Behzad , Baghbani Elham , Noorolyai Saeed
Published: August 2022

Background: MicroRNAs (miRNAs) can play essential roles in the modulation of cancer cell growth, survival, and resistance to chemotherapy. Thus, we hypothesized that restoration of miR-451a-5p (a tumor suppressor) might affect sensitivity to chemotherapeutics in breast cancer cells. Methods: For this purpose, malignant breast cancer cells (MDA-MB-231) were transfected with miR-451a-5p mimic and exposed with carboplatin. Then, the apoptotic rate was evaluated by flow cytometry and DAPI staining (apoptosis), q-RT-PCR (expression levels of caspase-3, caspase-8, MMP9, ROCK, vimentin, c-Myc genes). Moreover, the proliferation and migration of cancer cells were assessed by MTT (cell viability) and wound healing assay. The western blot assay was used for protein expression of PTEN, AKT, and P-AKT. Results: Our findings demonstrated that a combination of miR-451a-5p restoration with carboplatin administration could additionally induce apoptosis, repress the proliferation and migration, and also increase PTEN protein expression with no significant alteration on the AKT/P-AKT protein expressions in the breast cancer cells. The present data was analyzed using GraphPad Prism 6 software by non-parametric one-way ANOVA and t-test. Conclusion: In conclusion, it seems that overexpression of miR-451a can enhance the chemosensitivity of breast cancer cells to carboplatin therapy. Thus, it may shed new light on miR-451a management of breast cancer chemoresistance and may be a beneficial strategy for future cancer therapy. However, further studies, particularly in other signaling pathways, should be required.
Blockchain Teaching Simulation Using Gamification
Authors: Latifah Haznah , Fauziah Zaleha
Published: July 2022

A public blockchain simulation, which bears some resemblance to Bitcoin. All players are interconnected with several possibilities to form coin and block transactions and the power to get a taste of the consensus algorithm controlling transactions and blocks. A software medium that is based on blockchain games began using whiteboards to become web-based simulation games with various teaching scenarios. Contributive tool-based instruction with experience in blockchain concepts that can be used in the classroom as well as online. Along with this, simulations can give students the opportunity to experiment with all relevant blockchain operations like signing, creating transactions, building blocks, etc. This post was written to offer our firsthand experience teaching evolving blockchain technology to business and business information technology students at the undergraduate and graduate levels using newly built gamification teaching applications. This research is based on a design-based research methodology. We describe the process from identifying the problem, to designing the tool and demonstrating its implementation.
PEDIATRICS IN THE REFLECTION OF FALERISTICS
Authors: Бугаевский К.А. , Бугаевская Н.А.
Published: August 2022

В статье представлены результаты проведённого исследования, касающиеся представлению педиатрии в таких видах коллекционирования, как фалеристика. В работе представлены настольные и памятные медали, знаки участников конференций и съездов по педиатрии периода СССР и другой фалеристический материал, посвящённый различным разделам и направлениям современной педиатрии, и известным врачампедиатрам. Статья представляет интерес для широкого круга читателей.

The article presents the results of the research conducted on the presentation of pediatrics in such types of collectibles as faleristics. The work presents table and commemorative medals, signs of participants of conferences and congresses on pediatrics of the USSR period and other faleristic material devoted to various sections and directions of modern pediatrics and wellknown pediatricians.The article is of interest to a wide range of readers
Presentación
Authors: Cupe Calcina Eloy Marcelo
Published: August 2022

Nos es grato presentar el quinto número de Ius Vocatio. Revista de Investigación de la Corte Superior de Justicia de Huánuco, un órgano intelectual que ha persistido en su continuidad y rigurosidad académica, a pesar de las dificultades que las instituciones, como el Poder Judicial y la Corte Superior de Justicia de Huánuco, han enfrentado debido a la crisis sanitaria y económica ocasionadas por la pandemia de la COVID-19, situación que en este 2022 estamos superando como país. Este año es importante también para la revista, ya que la periodicidad de la misma es desde ahora semestral, lo cual no hace más que impulsar nuestro compromiso profesional que desempeñamos para esta noble misión de difundir los trabajos académicos de nuestros servidores judiciales, quienes promueven la investigación en los distintos ámbitos del derecho.
A BIBLIOMETRICS ANALYSIS ON MATHEMATICAL THINKING IN INDONESIA FROM SCOPUS ONLINE DATABASE WITH AFFILIATION FROM INDONESIA
Authors: Supriyadi Edi
Published: July 2022

Developing students' mathematical thinking is one of the most important objectives of mathematics education. Mathematical thinking in Indonesia is the focus of this study, which presents the results of a bibliometric investigation. This study aims to determine the development of mathematical thinking research publications and the distribution of research publications by type of publication, research institutes, and scientific journals in Indonesia on the Scopus online database. This study aims to determine the development of mathematical thinking research publications and the distribution of research publications by type of publication, research institutes, and scientific journals in Indonesia on the Scopus online database. This research is quantitative and descriptive. By collecting data from research on mathematical thinking in Indonesia in scientific journals at Scopus. Bibliometrics R-tool and BiblioShiny were used in this study. According to the findings of this bibliometric study, publication on mathematical thinking attained its pinnacle in 2019, marking the year when it realized its full potential. The publication outcomes are dominated by conference series journals. Authors submit their work to these journals by attending international conferences. Research on mathematical thinking is being conducted at Universitas Pendidikan Indonesia at a higher level than at any other Indonesian university. Furthermore, it is anticipated that future studies will make use of Bradford's theorem in order to present data that is more accurate for the purpose of the development of bibliometric studies.
Protección constitucional de los derechos y libertades individuales y de la colectividad en el Ecuador
Authors: Aguirre-Morán Erika Denisse , Villarroel-Quintuña Thelma Patricia , Alcivar-Castillo Nohemí Katherine , Torres-Parreño Amosandra Nayaska
Published: August 2022

Protección constitucional de los derechos y libertades individuales y de la colectividad en el Ecuador
Atención de pacientes críticos desde la medicina de urgencia y las unidades de cuidados intensivos
Authors: Pico-Macías Anggie Evelyn , Mesías-Mercado Emma Marisela , Mendoza-Pico Valeria Valentina , Margari-Álvarez Allison Berenice
Published: August 2022

El objetivo general de la presente investigación fue describir la mejoría de la atención de pacientes críticos desde la medicina de urgencia y las unidades de cuidados intensivos. En la presente investigación se empleó la metodología desde el enfoque cuantitativo, apoyada en la recolección y análisis de una tipología documental-bibliográfica, lo cual consistió en el análisis de artículos científicos arbitrados, de investigación y trabajos de grado. Se planteó además el método analítico-sintético por medio del cual, se descompone un todo en partes extrayendo cualidades, componentes, relaciones y posteriormente unir las partes analizadas. Se concluye que la mejoría de la atención de pacientes críticos desde la medicina de urgencia y las unidades de cuidados intensivos, es un proceso que está en desarrollo y mejora de acuerdo a los nuevos desafíos que se presentan en el campo de la salud y cuyo fin es una atención integral del paciente y sus familiares.
La malaria y métodos actuales de estimación de riesgo en comunidades afectadas
Authors: Cedeño-Zavalu Vanessa Monserrate , Montes-Ferrin Reinerio José , Piguave-Reyes José Manuel , Cedeño-Zavalu Wilter Maximiliano
Published: August 2022

El objetivo general fue analizar la malaria y métodos actuales de estimación de riesgo en comunidades afectadas. La metodología empleada se enfocó desde el paradigma positivista y perspectiva cuantitativa, para la producción de datos descriptivos, por la recolección de datos, apoyada en una metodología documental-bibliográfica. Además, se apoyó primordialmente en documentos escritos como trabajos arbitrados y científicos, planteándose una revisión y reflexión detallada obteniendo los datos necesarios para el desarrollo teórico. Se aplicó también el método inductivo-deductivo. Como resultado se observó como a través de los organismos internacionales existe la preocupación por la erradicación definitiva de la malaria estableciendo métodos y estrategias para disminuir los riesgos en comunidades afectadas. Se concluye, que la malaria conocida también como paludismo, es una afección a nivel mundial y que ataca a los miembros de algunas comunidades hasta una familia completa, ocasionando un gran daño, los organismos internacionales establecieron protocolos para combatir dicho flagelo.
Principio constitucional de irrenunciabilidad de los derechos e intereses del trabajador
Authors: Loor-Quijije Samantha Pilar , Lemos-Espinoza Aura Marina , Estupiñan-Vélez Josselyn Anahi , Atencio-González Rously Eedyah
Published: August 2022

Principio constitucional de irrenunciabilidad de los derechos e intereses del trabajador
Violencia y Estado desde una visión política
Authors: Najera-Tello Geovanna Michelle , Barroso-Ramírez Mirian Marcela , Castro-Mosquera Alma Cristina , Peñaherrera-Martínez Elba Tatiana
Published: August 2022

Violencia y Estado desde una visión política
Síndrome de Burnout y funcionamiento familiar
Authors: Delgado-Cevallos Daniela Vanessa , Cañizares-Medina Andrés Ernesto , Fernández-Aucapiña Nancy Yolanda
Published: August 2022

El presente estudio se enfocó en determinar el Síndrome de Burnout y su incidencia en el funcionamiento familiar en docentes de la Unidad Académica de Ciencias Sociales de la UCACUE, Cuenca, Ecuador; el proceso metodológico es de tipo descriptivo con un enfoque cuantitativo. Las herramientas de recolección de información que se utilizaron fueron el cuestionario de Maslash Burnout Inventory (MBI). la funcionalidad familiar está comprendida por la interacción entre cada uno de los miembros de la familia, mediante el test  FF-SIL que evalúa varias categorías que permiten determinar un diagnóstico de la funcionalidad familiar, mediante la evaluación del mismo se identifica que la funcionalidad familiar no está correlacionada con el síndrome de Burnout puesto que se identifica que el 84.38% y 12.5% de docentes tienen una familia funcional y moderadamente funcional y tan solo el 3,12% presenta a familia severamente disfuncional.
Measuring anxiety among young English language learners: Application of digital games for evaluation
Authors: Amoroso-Vivanco María Paulina , Vega-Auquilla Melita Vanessa
Published: August 2022

The purpose of the following study was to evaluate how the impact of technology affects the anxiety of elementary school students in English classes in a private school in Cuenca, Ecuador. Through a mixed method approach using the Beck Anxiety Inventory (BAI). Results showed that students experienced a statistically significant decrease in anxiety after being assessed through Quizizz games compared to traditional pencil-and-paper assessments. It was also found that students' anxieties regarding assessments were primarily triggered by fear of consequences, failure, and not achieving perfect scores.  Further research over longer periods is recommended.