bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
Authors: Weng Zhijie , Zhang Bowen , Wu Chenzhou , Yu Fanyuan , Han Bo , Li Bo , Li Longjiang
Published: September 2021

Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression in different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested that MSC-derived EVs could mimic their parental cells, possessing pro-tumor and anti-tumor effects, and inherent tumor tropism. Therefore, MSC-derived EVs can be a cell-free cancer treatment alternative. This review discusses different insights regarding MSC-derived EVs' roles in cancer treatment and summarizes bioengineered MSC-derived EVs’ applications as safe and versatile anti-tumor agent delivery platforms. Meanwhile, current hurdles of moving MSC-derived EVs from bench to bedside are also discussed.
CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer
Authors: Nie Sipei , Wan Yicong , Wang Hui , Liu Jinhui , Yang Jing , Sun Rui , Meng Huangyang , Ma Xiaolin , Jiang Yi , Cheng Wenjun
Published: September 2021

Tumor microenvironment and chemokines play a significant role in cancer chemoresistance. This study was designed to reveal the important role of CXCL2 in platinum resistance in epithelial ovarian cancer (EOC). Differently expressed (DE) genes were screen out based on analysis of GSE114206 dataset in GEO database. The expression of DE chemokines was further validated in platinum- resistant and sensitive EOC. Cell viability assay and cell apoptosis assay were performed to explore the roles of CXCL2 in EOC. Cell stemness characteristics and the signaling pathway regulated by CXCL2 were also investigated in this study. As the results showed, CXCL2 was identified up-regulated in platinum-resistant EOC. The functional assays showed overexpressing CXCL2 or co-culturing with recombinant human CXCL2 promoted cell resistance to cisplatin. Conversely, knocking down CXCL2 or co-culturing with neutralizing antibody to CXCL2 increased cell response to cisplatin. CXCL2 overexpressing maintained cell stemness and activated ATR/CHK1 signaling pathway in EOC. Moreover, we further demonstrated that CXCL2-mediated resistance to cisplatin could be saved by SB225002, the inhibitor of CXCL2 receptor, as well as be rescued by SAR-020106, the inhibitor of ATR/CHK1 signaling pathway. This study identified a CXCL2-mediated mechanism in EOC platinum resistance. Our findings provided a novel target for chemoresistance prevention in EOC.
Ovarian inguinal hernia – a possibility in MURCS syndrome
Authors: Saini Rahul , Bains Lovenish , Kaur Tarangpreet , Lal Pawan , Pal Veer , Beg Mohd Yasir , Kaur Daljit
Published: September 2021

Background

Inguinal hernia containing ovary and fallopian tube can be found in paediatric population and is a rare finding in women of reproductive age group. Most of the cases are associated with congenital abnormalities of the female genital tract.

Case presentation

A 20 year old female presented with right reducible inguinal hernia, primary amenorrhea and normal secondary sexual characteristics. Clinical examination revealed scoliosis with convexity towards left side, prominence of left rib cage with Sprengel deformity and right sided heart sounds. Ultrasound of the inguinal swelling revealed right ovary within the hernial sac, Chest X-ray revealed right lung collapse and dextrocardia. Further Magnetic resonance imaging (MRI) of pelvis revealed inguinal hernia with right ovary as its content, normal left ovary and absent uterus. Computed tomography (CT) revealed complete collapse of right lung with compensatory left lung hyperinflation and absent right kidney. Karyotyping of the patient was normal, 46XX. A diagnosis of MURCS syndrome with right ovarian hernia was made. The hernia was surgically managed with repositioning of ovary and fallopian tube into the pelvis.

Discussion

Ovary in inguinal hernia is rare in women of reproductive age group. MRKH syndrome, a mullerian duct anomaly, is the congenital aplasia of uterus and upper two-thirds of vagina in a female with normal ovaries, fallopian tube, secondary sexual characteristics and 46XX karyotype. MURCS is a subtype of MRKH type 2 having mullerian duct agenesis with renal, cardiac, muscular & vertebral defects. General physical examination and primary investigations if yields abnormal findings; the patient must undergo an array of investigations to rule out MRKH/MURCS, or other congenital abnormality. Early diagnosis is essential to prevent its incarceration or torsion. The primary treatment of ovary in inguinal hernia is repositioning the ovary and fallopian tube back to pelvis to preserve fertility and repair of inguinal hernia. A multidisciplinary team is required to deal with various abnormalities present in a patient with MURCS.
Introgression among North American wild grapes (Vitis) fuels biotic and abiotic adaptation
Authors: Morales-Cruz Abraham , Aguirre-Liguori Jonas A. , Zhou Yongfeng , Minio Andrea , Riaz Summaira , Walker Andrew M. , Cantu Dario , Gaut Brandon S.
Published: September 2021

Background

Introgressive hybridization can reassort genetic variants into beneficial combinations, permitting adaptation to new ecological niches. To evaluate evolutionary patterns and dynamics that contribute to introgression, we investigate six wildVitisspecies that are native to the Southwestern United States and useful for breeding grapevine (V. vinifera) rootstocks.

Results

By creating a reference genome assembly from one wild species,V. arizonica, and by resequencing 130 accessions, we focus on identifying putatively introgressed regions (pIRs) between species. We find six species pairs with signals of introgression between them, comprising up to ~ 8% of the extant genome for some pairs. The pIRs tend to be gene poor, located in regions of high recombination and enriched for genes implicated in disease resistance functions. To assess potential pIR function, we explore SNP associations to bioclimatic variables and to bacterial levels after infection with the causative agent of Pierce’s disease (Xylella fastidiosa). pIRs are enriched for SNPs associated with both climate and bacterial levels, suggesting that introgression is driven by adaptation to biotic and abiotic stressors.

Conclusions

Altogether, this study yields insights into the genomic extent of introgression, potential pressures that shape adaptive introgression, and the evolutionary history of economically important wild relatives of a critical crop.
Efficacy of Yijinjing combined with Tuina for patients with non-specific chronic neck pain: study protocol for a randomized controlled trial
Authors: Cheng Ziji , Chen Ziying , Xie Fangfang , Guan Chong , Gu Yuanjia , Wang Ruiping , You Yanli , Yao Fei
Published: September 2021

Background

Non-specific chronic neck pain (NCNP) is a common musculoskeletal disorder which has caused a huge economic burden due to its expensive health costs and high re-occurrence rate. Yijinjing and Tuina are widely used for non-specific chronic neck pain in China. But there is little scientific evidence to evaluate their efficacy for NCNP. The aim of this research is to compare the efficacy of Yijinjng combined with Tuina versus Tuina for patients with NCNP.

Methods/design

A randomized controlled trial in which 102 patients with non-specific chronic neck pain will be recruited and randomly allocated to either the Tuina group or the Yijinjng combined with Tuina group in a 1:1 ratio. The interventions for both groups will be carried out three times a week for 8 weeks. The patients in the two groups will receive follow-up 1 month after the intervention. The primary outcome will be the changes in the visual analog scale (VAS). Secondary outcomes will be measured by the Neck Disability Index (NDI), Self-Rating Anxiety Scale (SAS), and Tissue Hardness and Active Range of Motion (AROM). The data will be analyzed at the baseline, 4 weeks during the intervention, at the end of the intervention, and 1 month after the intervention. The significance level sets as 5%. The safety of interventions will be evaluated after each treatment session.

Discussion

The purpose of this trial is to determine whether Yijinjing combined with Tuina is not inferior to Tuina for patients with NCNP. This study will provide clinicians and stakeholders much-needed knowledge for a complementary and alternative therapy for patients with non-specific chronic neck pain.

Trial registration

ChiCTR registry (ChiCTR) 2000036805. Registered on August 25, 2020
The effect of in-person and virtual prenatal care education of the spouses of primiparous women on the father and mother’s attachment to infant: a quasi-experimental and controlled study
Authors: Doaltabadi Zari , Amiri-Farahani Leila
Published: September 2021

Introduction

Considering the important role of education in promoting parents’ attachment to the infant, temporal and spatial limitations, and the need to use new educational methods for spouses’ participation in childbirth preparation classes, the present study was conducted to compare the effect of in-person and virtual prenatal care education of the spouses of primiparous women on the father and mother’s attachment to the infant.

Methods

This is a quasi-experimental clinical trial that was conducted on primiparous pregnant women referring to three prenatal clinics in Tehran, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of face-to-face education (n = 28), virtual education (n = 31), and control (n = 29). The content of the training program in the virtual and face-to-face groups was similar, which was presented in 4 sessions. At 18–20 weeks of gestation, demographic characteristics and pregnancy records were obtained from the samples, and 12 weeks after the delivery, maternal postnatal attachment scale, and postnatal paternal-infant attachment questionnaire were completed. Both intention-to-treat analysis and per-protocol analysis were performed.

Results

There was a statistically significant difference between the two groups of in-person education and control, and also virtual education and control for both intention-to-treat and per-protocol analysis (p < 0.05). However, no statistically significant difference was found between the two groups of in-person and virtual education. Results showed a large and medium effect size between the two groups of in-person education and control, and virtual education and control in terms of father-infant attachment score, respectively. There was also no statistically significant difference between the three groups after the educational intervention in terms of the mother-infant attachment score for both intention-to-treat and per-protocol analysis.

Conclusion

Considering that education by both in-person and virtual methods had the same effect on improving the score of father-infant attachment, it is suggested that to increase the participation of spouses of pregnant women in the process of prenatal care, the spouses of pregnant women should have the option of virtual education in addition to in-person training.

Trial registration

TCTR.ir TCTR20200515011. Registered on May 12, 2020.
Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load
Authors: Reijm Sanne , Kissel Theresa , Stoeken-Rijsbergen Gerrie , Slot Linda M. , Wortel Corrie M. , van Dooren Hugo J. , Levarht Nivine E. W. , Kampstra Arieke S. B. , Derksen Veerle F. A. M. , Heer Pleuni Ooijevaar-de , Bang Holger , Drijfhout Jan W. , Trouw Leendert A. , Huizinga Tom W. J. , Rispens Theo , Scherer Hans U. , Toes René E. M.
Published: September 2021

Background

Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs) is evident, it is unknown whether the first responding B cells, expressing IgM, display similar characteristics or if cross-reactivity is crucially dependent on somatic hypermutation (SHM). We now studied the reactivity of (germline) AMPA-IgM to further understand the breach of B cell tolerance and to identify if cross-reactivity depends on extensive SHM. Moreover, we investigated whether AMPA-IgM can efficiently recruit immune effector mechanisms.

Methods

Polyclonal AMPA-IgM were isolated from RA patients and assessed for cross-reactivity towards PTM antigens. AMPA-IgM B cell receptor sequences were obtained by single cell isolation using antigen-specific tetramers. Subsequently, pentameric monoclonal AMPA-IgM, their germline counterparts and monomeric IgG variants were generated. The antibodies were analysed on a panel of PTM antigens and tested for complement activation.

Results

Pentameric monoclonal and polyclonal AMPA-IgM displayed cross-reactivity to multiple antigens and different PTMs. PTM antigen recognition was still present, although reduced, after reverting the IgM into germline. Valency of AMPA-IgM was crucial for antigen recognition as PTM-reactivity significantly decreased when AMPA-IgM were expressed as IgG. Furthermore, AMPA-IgM was 15- to 30-fold more potent in complement-activation compared to AMPA-IgG.

Conclusions

We provide first evidence that AMPA-IgM are cross-reactive towards different PTMs, indicating that PTM (cross-)reactivity is not confined to IgG and does not necessarily depend on extensive somatic hypermutation. Moreover, our data indicate that a diverse set of PTM antigens could be involved in the initial tolerance breach in RA and suggest that AMPA-IgM can induce complement-activation and thereby inflammation.
Differential horizontal migration patterns of two male salmon sharks (Lamna ditropis) tagged in the Bering Sea
Authors: Garcia Sabrina , Tribuzio Cindy A. , Seitz Andrew C. , Courtney Michael B. , Nielsen Julie K. , Murphy Jim M. , Oxman Dion S.
Published: September 2021

Background

The salmon shark (Lamna ditropis) is a widely distributed apex predator in the North Pacific Ocean. Many salmon sharks from the eastern North Pacific, specifically Prince William Sound, Alaska, have been satellite tagged and tracked, but due to the sexual segregation present in salmon sharks, most of these tagged sharks were female. Consequently, little information exists regarding the migration patterns of male salmon sharks. To better understand the migration and distribution of this species, information on the male component of the population as well as from sharks outside of Prince William Sound, Alaska, is needed. In this study, we deployed satellite transmitters on two mature male salmon sharks caught in the Bering Sea.

Results

The two mature male salmon sharks tagged in the Bering Sea exhibited distinct migration patterns. The first male, tagged in August 2017, traveled to southern California where it remained from January to April after which it traveled north along the United States’ coast and returned to the Bering Sea in August 2018. The second male, tagged in September 2019, remained in the North Pacific between 38° N and 50° N before returning to the Bering Sea in July of year one and as of its last known location in year two. The straight-line distance traveled by the 2017 and 2019 sharks during their 12 and 22 months at liberty was 18,775 km and 27,100 km, respectively.

Conclusions

Before this study, our understanding of salmon shark migration was limited to female salmon sharks satellite tagged in the eastern North Pacific. The 2017 male salmon shark undertook a similar, but longer, north–south migration as tagged female sharks whereas the 2019 shark showed little overlap with previously tagged females. The different migration patterns between the two male sharks suggest distinct areas exist for foraging across the North Pacific. The return of both sharks to the Bering Sea suggests some fidelity to the region. Continued tagging efforts are necessary to understand the population structure of salmon sharks in the North Pacific. This tagging study highlights the importance of opportunistic efforts for obtaining information on species and sex with limited distribution data.
Preliminary results of Preserflo Microshunt versus Preserflo Microshunt and Ologen implantation
Authors: Vastardis Iraklis , Fili Sofia , Perdikakis Georgios , Kontopoulou Kalliopi , Balidis Miltos , Gatzioufas Zisis , Kohlhaas Markus
Published: September 2021

Purpose

To report preliminary 6-month results on the use of the Preserflo Microshunt implant with and without Ologen in 50 pseudophakic eyes with moderate to advanced primary open-angle glaucoma (POAG).

Methods

Fifty pseudophakic eyes underwent ab externo Preserflo Microshunt implantation. Data was gathered retrospectively and two groups were then created, group A with application of MMC 0.2 mg/ml and group B with MMC 0.2 mg/ml and Ologen collagen matrix (OCM) implantation. Absolute success was regarded as the percentage of eyes achieving: a) 5 ≤ intraocular pressure (IOP) ≤ 13 mmHg, b) 5 ≤ IOP ≤ 16 mmHg, and c) 5 ≤ IOP ≤ 21 mmHg without additional medication or surgery and qualified success was regarded as the percentage of eyes achieving a) IOP ≤ 13 mmHg, b) IOP ≤ 16 mmHg, and c) IOP ≤ 21 mmHg with or without medication. Evaluation was performed using a log-rank Kaplan-Meier test. A scatterplot analysis presented the treatment effect data of all eyes with a minimum of 20% IOP reduction per case. Failure was defined as requiring additional surgery, IOP greater than 21 mmHg with or without medication and failure to reach 20% IOP reduction.

Results

Mean postoperative IOP was significantly lower in both groups. IOP decreased by 49.06% in group A and by 53.01% in group B at 6 months (P < 0.88), respectively. Medication use was lower in both groups (Wilcoxon test, P < 0.001). The absolute and qualified success rates were not statistically significant between the groups (all P > 0.05). Cumulative IOP results per case were not statistically different in group A compared with group B. One revision surgery in group A (4% failure rate) and three in group B (12% failure rate) were performed.

Conclusions

Both groups showed equal results in terms of cumulative and mean IOP reduction, medication reduction as well as in absolute and qualified success rates. No significant difference was found in any parameters tested between Preserflo Microshunt with MMC 0.2 mg/ml and with or without OCM implantation at 6 months. Long-term follow-up is required to further evaluate this data.
Perineal stapled prolapse resection in combination with Thiersch operation for relapsed rectal prolapse: a case report
Authors: Kamada Teppei , Ohdaira Hironori , Takahashi Junji , Fuse Yoshinobu , Kai Wataru , Nakashima Keigo , Nakaseko Yuichi , Suzuki Norihiko , Yoshida Masashi , Usui Takeo , Suzuki Yutaka
Published: September 2021

Background

Treatment options for complete rectal prolapse include over 100 procedures. In previous reports, operative rectal prolapse repair, regardless of the technique by perineal approach, was associated with high recurrence rates. However, there is no consensus on the optimal surgical procedure for relapsed rectal prolapse.

Case presentation

A 97-year-old woman was admitted to our hospital with a chief complaint of complete rectal prolapse measuring > 5 cm. The patient had a history of laparoscopic anterior suture rectopexy without sigmoid resection under general anesthesia for complete rectal prolapse one year prior. The patient’s postoperative course was uneventful. However, her dementia worsened (Hasegawa’s dementia scale: 5/30 points) after the first operation. Further, moderate-to-severe aortic valve stenosis was first diagnosed with heart failure 6 months after the operation. Nine months after the initial surgery, she experienced a recurrence of complete rectal prolapse measuring approximately 5 cm. Considering the coexistence of advanced age, severe dementia, and aortic valve stenosis, surgery under general anesthesia was not indicated. Perineal stapled prolapse resection in combination with the t operation was planned because of its minimal invasiveness and shortened hospital stay. The procedure was performed by a team of two surgeons in the jack knife position, under spinal anesthesia.

The prolapse was cut along the long-axis direction with three linear staplers and resected along the short-axis direction with four linear staplers. The cross-section of the linear stapler was reinforced with 3-0 Vicryl sutures. After rectal resection, the Thiersch operation using 1-0 nylon thread 1 cm away from the anal verge was additionally performed. The operative time was 24 min, and intraoperative blood loss was 1 mL. The postoperative course was uneventful. Three months after the operation, no recurrence was observed, and defecation function was good with improvements of Wexner score.

Conclusions

Perineal stapled prolapse resection in combination with the Thiersch operation could be a useful option for patients with relapsed rectal prolapse and with poor general condition, who are not indicated for other surgical procedures.
Pain management during labor: use of intermittent drug delivery devices for improvement of obstetric and neonatal outcome and reduction of healthcare burden: A large non-inferiority randomized clinical trial
Authors: Rinaldi Laura , Ghirardini Anna Maria , Troglio Raffaella , Bellini Valentina , Donno Lara , Biondini Susanna , Biagioni Emanuela , Baciarello Marco , Bignami Elena , Girardis Massimo
Published: September 2021

Background

Automated continuous epidural administration of local anesthetics provides a more stable analgesic block with decreasing of healthcare staff compared to manual boluses administration (TOP-UP) but is associated to high rate of operative vaginal delivery. We hypothesized that the use of programmed intermittent automated boluses (PIEB) is able to provide a good quality of analgesia and decreasing of anesthesiologic workload without increasing the rate of instrumental vaginal birth in comparison with TOP-UP technique. Laboring nulliparous woman aged between 18 and 46 years were randomized to epidural analgesia with 0.0625% levobupivacaine and sufentanil administered by PIEB or by TOP-UP techniques. Primary outcome was instrumental vaginal delivery rate and secondary outcomes were quality of analgesia, total and time-related drugs doses used, motor block, newborn outcome, and anesthesiologic workload.

Results

Six hundred twenty-nine were randomized, and 628 were included in the intention-to-treat analysis. The rate of instrumental vaginal delivery was similar in the PIEB and TOP-UP groups (13.2% vs 9.7%, OR 1.4 95% CI 0.8 to 2.5; p 0.21). There was no difference between groups regarding mode of delivery (cesarean section vs vaginal birth), newborn outcome, and motor block. Patients in the PIEB group received more total and time-related drugs doses and a better quality of analgesia. Anesthesiological workload was significantly reduced in the PIEB group.

Conclusions

Our study demonstrated that epidural anesthesia with programmed intermittent epidural boluses by an automated device provides an effective and safe management of labor analgesia with improvement of pain control and sparing of man workload compared to manual top-up protocols.
An optimal finite-difference method based on the elongated stencil for 2D frequency-domain acoustic-wave modeling
Authors: Li Shizhong , Sun Chengyu , Wu Han , Cai Ruiqian , Xu Ning
Published: September 2021

Frequency-domain finite-difference (FDFD) modeling plays an important role in exploration seismology. However, a major disadvantage of FDFD modeling is the computational cost, especially for large-scale models. By compactly distributing nonzero strips, the elongated stencil helps to generate a narrow-bandwidth impedance matrix, improving computational efficiency without sacrificing numerical accuracy. To further improve the accuracy and efficiency of modeling, we have developed an optimal FDFD method with an elongated stencil for 2D acoustic-wave modeling. The Laplacian term is approximated using the directional-derivative method and the average-derivative method. The dispersion analysis indicates that this elongated-stencil-based method (ESM) achieves higher accuracy than other finite-difference methods with the elongated stencil, and it is more suitable for large grid-spacing ratios. To keep the phase-velocity error within 1%, 15-point and 21-point schemes in the ESM only require approximately 2.28 and 2.19 grid points per wavelength, respectively, when the grid-spacing ratio, namely, the ratio of directional sampling intervals, is not less than 1.5. Moreover, we also adopt a variable-stencil-length scheme, in which the stencil length varies with the velocity, to further reduce the computational cost in frequency-domain modeling. Several numerical examples are presented to demonstrate the effectiveness of our ESM.
Emplotment beyond the Human Scale: On Deep Time and Narrative Nonlinearity
Authors: Caracciolo Marco
Published: September 2021

In the second volume of Time and Narrative (1985, 101–12), Paul Ricoeur distinguishes between two layers of temporality in Virginia Woolf's Mrs. Dalloway (1925): he calls them “monumental” time and “mortal” time. The former is connected with authority and British imperial politics; the latter is the subjective, highly malleable time of human experience. But there is another time, also active in Woolf's novel and in her oeuvre more generally, that Ricoeur seems to overlook. It is the “deep history” (Shryock and Smail 2011) of geological and planetary phenomena that vastly surpasses the time scale of individual humans or human societies, or even of the human species. This is not to say that narrative is at ease with this deep temporality; as a practice, it seems fundamentally skewed toward the ethical and hermeneutic concerns that Ricoeur foregrounds in his work. But deep time does surface in narrative; this article is concerned with the formal challenges raised by such surfacings.
Contrast-enhanced ultrasonography promotes differential diagnosis of ureteral neoplasms
Authors: Bai Yun , Lin Jun , Chen An , Bai Min , Li Chunxiao , Cai Yingyu , Yu Jie , Hu Wenjie , Du Lianfang , Li Fan
Published: September 2021

Objective:

To compare the diagnostic value of contrast-enhanced ultrasonography (CEUS) with baseline ultrasound (B-US) in ureteral neoplasms.

Methods:

Retrospective analysis, comprising clinical presentation, image appearances, and diagnostic results on B-ultrasound and CEUS, considering pathological result as a gold-standard, was conducted on the clinical information of 39 patients with ureteral neoplasms. CT urography was used to detect and confirm the presence of ureteral neoplasms. Both B-ultrasound and CEUS investigations of those 39 patients under study were performed by a senior radiologist.

Results:

Pathological outcomes established 27 ureteral malignancies and 12 ureteral benignancies. Ureteral malignancies were observed to occur in older patients than benignancies (p = 0.002). Only the morphological indicator of the ureteric wall on B-ultrasound was different in ureteral malignancies and benignancies (p = 0.030). Tumors with hyperenhancement, larger width, and hyperenhanced ureteric wall were easily diagnosed as malignant on CEUS, whereas iso-/hypoenhanced, narrower, and iso-/hypoenhanced ureteric wall indicated benign tumors. Moreover, the lesion widths, enhanced morphologies of the ureteric wall, and the ureteral wall’s linear boundaries on CEUS were different between high- and low-stage ureteral urothelial carcinomas (p = 0.012, 0.002, 0.001, respectively).

Conclusion:

The display of microvessels in ureteral neoplasms was significantly enhanced by CEUS, thus contributing to the differential diagnosis of ureteral neoplasms while assisting the staging of ureteral urothelial carcinoma.

Advances in knowledge:

The imaging features of different ureteral neoplasms on CEUS were analyzed in this study. The diagnostic performances of CEUS and B-ultrasound in ureteral urothelial carcinomas were also explored.
Case Report: Scientific Dissemination as a Mediator of the Research Consolidation Process: Proposals for Institutionalization
Authors: Galvão Tássia , Tavares Kamilla Assis , Fernandes Michele , Souza José Carlos Moreira de , Noll Matias
Published: September 2021

Introduction

Communicating science is one of the main steps in the research process. However, the method of communication must be aligned with the audience for the message. This is especially evident in institutions that promote teaching, research, and extension, especially when considering joint actions that promote a dialogue between themselves and the community.

Methods

In light of this need, this study was conducted with the aim of analyzing the main documents guiding the policies and institutional actions related to research at the two federal institutes based in the state of Goiás/Brazil: Institution A and Institution B and proposing ways to include scientific dissemination as a mediator of the research consolidation process. This is a bibliographic, documentary study with a descriptive, qualitative approach based on a case study.

Results and Discussion

The analyses indicate that research must be consolidated as institutional policy and that a policy to encourage research must be implemented. This has yet to be achieved at these institutions, although scientific dissemination is explicitly addressed by institutional documents guiding the development and dissemination of pedagogical practices, especially in teaching and extension. Scientific journalism and scientific dissemination are mediators and facilitators of this endeavor.
УПРАВЛЕНИЕ СОЦИАЛЬНОЙ СИСТЕМОЙ В УСЛОВИЯХ ВЗАИМОДЕЙСТВИЯ СОЦИУМА И ОБРАЗОВАТЕЛЬНОГО ПРОЦЕССА В ТЕХНИЧЕСКОМ ВУЗЕ
Authors: Bespalova Natalia A. , Sibirtsev Anton V. , Yakovleva Tatyana S.
Published: September 2021

Цель. Статья посвящена актуальной в условиях развития высшего образования теме совершенствования управления социальной системой в условиях взаимодействия социума и образовательного процесса в техническом вузе. Актуальность темы статьи обусловлена тем, что правильный выбор моделей педагогического взаимодействия в техническом вузе и подходов в управлении социальной системой вуза позволит повысить качество образовательного процесса. Предметом исследования является социальная система технического вуза.

Методология. Основу исследования образуют следующие методы исследования: сущностный, структурно-функциональный, метод сравнения, и группа логических методов: анализ, синтез, обобщение.

Результаты. В результате исследования определены понятия социальной системы технического вуза, особенностей взаимодействия социума и образовательного процесса в техническом вузе. Рассмотрены особенности педагогического взаимодействия в рамках образовательного процесса на примере модели активного взаимодействия и либеральной модели. Дана характеристика основных подходов к управлению качеством подготовки выпускников технических вузов. Рассмотрены преимущества внедрения системы менеджмента качества в управление техническим вузом для укрепления взаимосвязей между наукой, высшим образованием и производством.

Область применения результатов. Результаты проведенного исследования могут использоваться на практике для повышения эффективности управления социальной системой технического вуза. Так, применение такой модели педагогического взаимодействия в рамках образовательного, как активное взаимодействия возможно на любом этапе образовательного процесса, а либеральная модель может применяться на этапе магистратуры или аспирантуры, а также второго высшего образования. Также для управления социальной системой вуза может быть применен подход, базирующийся на создании системы менеджмента качества предоставляемых услуг в соответствии с требованиями ГОСТа.

Выводы. Проведенное исследование позволило сделать выводы о преимуществах применения моделей активного взаимодействия и либеральной модели для совершенствования педагогического взаимодействия в техническом вузе. Рассмотрение особенностей педагогического взаимодействия в рамках образовательного процесса на примере модели активного взаимодействия и либеральной модели позволило определить, что применение модели активного взаимодействия возможно на любом этапе образовательного процесса, тогда как либеральная модель может применяться на этапе магистратуры или аспирантуры, а также второго высшего образования. Дана характеристика основных подходов к управлению качеством подготовки выпускников технических вузов. Сделан вывод о том, что для повышения эффективности взаимодействия социума и образовательного процесса в техническом вузе более подойдет подход, базирующийся на создании системы менеджмента качества предоставляемых услуг.
ИНТЕРПРЕТАЦИЯ РУССКИХ РЕАЛИЙ В ПЕРЕВОДАХ ПРОИЗВЕДЕНИЙ И.А. БУНИНА
Authors: Yavari Yulia V. , Dzhafarova Lyubov A.
Published: September 2021

Статья посвящена анализу способов перевода на английский язык русских реалий, носителей национального и исторического колорита в произведениях И.А. Бунина «Деревня», «Суходол» и рассказе «Антоновские яблоки».
Цель исследования: описать и сравнить основные особенности перевода исследуемых лексических единиц и выявить наиболее продуктивные модели перевода реалий.
Методы исследования. Исследуемые реалии были определены методом сплошной выборки из повестей русского классика И.А. Бунина «Деревня», «Суходол» и рассказа «Антоновские яблоки». Основу исследования образуют структурный анализ и сравнительно-­описательный метод.
Результаты исследования. Сопоставительный анализ способов перевода реалий, обозначающих предметы быта, одежду, блюда, сословия, социальные группы и должности, характерные для жизни русской деревни 19 в., показал, что наиболее частотными способами, используемыми переводчиками, являются: транскрипция (как с пояснениями, так и без таковых), гиперонимический перевод, описательный перевод и замена реалии. Авторы статьи рассматривают художественный перевод как базу для пополнения литературного переводящего языка (ПЯ) новыми словами. В заключение сделан вывод, что, используя опыт перевода и опираясь на знание экстралингвистических факторов, можно достичь адекватного перевода.
Практическое применение результатов. Результаты исследования могут использоваться при чтении курсов лекций и проведении практических занятий по теории перевода в процессе обучения переводчиков в сфере профессиональной коммуникации.
Narrativas de um real em ruínas: dois momentos da literatura portuguesa pós-25 de abril
Authors: Franco Roberta Guimarães , Bernardes Karol Sousa
Published: September 2021

Diversos críticos têm apontado para uma espécie de recuperação do realismo na narrativa portuguesa contemporânea, especialmente naquela produzida após o fim do Estado Novo e a consequente descolonização dos territórios africanos. Se o período entre as décadas de 30 e 70 do século XX foi marcado por silenciamentos e censura, após a Revolução dos Cravos, em 1974, vemos o surgimento de vários romances que trazem principalmente o tema da Guerra Colonial como foco. Por outro lado, alguns desdobramentos desse contexto, como a condição dos retornados na sociedade portuguesa, parecem surgir somente em um momento posterior, sobretudo a partir da década de 90, e vem ganhando novo fôlego no século XXI. Nesse sentido, este artigo propõe-se a realizar uma análise do que identificamos como dois momentos de abordagem do real na literatura portuguesa contemporânea: o primeiro, voltado para os anos imediatamente após a Revolução dos Cravos e observando um foco maior no cenário da Guerra Colonial, a partir das obras Os Cus de Judas (1979), Autópsia de um mar de ruínas (1984), A Costa dos Murmúrios (1988) e Jornada de África (1989); e o segundo recorte a partir do final do século XX e até o início da segunda década do século XXI, com as obras O esplendor de Portugal (1997), Caderno de memórias coloniais (2009) e O retorno (2012), que já trazem uma atenção especial à situação dos retornados. Em comum, os dois momentos acabam por identificar uma realidade de ruína, especialmente do imaginário criado pelos discursos do Estado Novo.
POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS: BREVE ANÁLISE DO LEGADO DE UMA DÉCADA
Authors: Da Silva dos Santos Jorge Edmir , Henriques Pereira van Elk Ana Ghislane
Published: September 2021

A Política Nacional de Resíduos Sólidos completou a sua primeira década de existência, portanto é relevante que se avalie os principais resultados para o setor obtidos pela lei. Com esse objetivo, os dados do Panorama dos Resíduos Sólidos no Brasil publicados pela Associação Brasileira de Empresas de Limpeza Urbana e Resíduos Especiais foram analisados. A breve análise do desempenho dos indicadores selecionados (despesa municipal, geração, coleta, coleta seletiva, disposição final e reciclagem) permitiu concluir que a evolução da gestão de resíduos sólidos no período foi discreta. O Brasil atualmente é um dos maiores geradores de resíduos sólidos do mundo, milhares de toneladas de resíduos sólidos são dispostos diariamente em lixões e a reciclagem é um grande desafio.
RESSURGÊNCIA: UM ESTUDO ESTATÍSTICO DE TEMPERATURA E SALINIDADE DA BOIA 19°00’S34°00’W
Authors: Simões Paulo Henrique Couto , Serra Costa José Fabiano da , Provenza Marcello Montillo , Xavier Vinicius Layter , Goulart Jorge Luiz de Jesus
Published: September 2021

Os mais de sete mil quilômetros do litoral brasileiro constituem uma zona de riqueza ímpar do nosso país onde se concentra grande parte da população brasileira. É na região costeira onde se realiza grande parte da pesca, da navegação, da extração de petróleo, do lazer e do turismo do Brasil. Nesse cenário, um conhecimento das condições oceânicas existentes ao longo do nosso litoral torna-se cada vez mais necessário. Diversos programas incentivam e executam atividades relacionadas ao estudo dos oceanos. Nesse trabalho, será analisada a base de dados do GOOS-BRASIL que é um sistema nacional de observação dos oceanos. O objetivo do presente estudo é modelar a série temporal entre 2005 e 2014 das temperaturas e salinidades médias a um metro de profundidade, coletadas da boia ATLAS (posição geográfica 19°00S34°00W) da rede PIRATA. Inicialmente foram feitas as análises de estacionariedade e sazonalidade, para posteriormente elaborar as previsões. Foram utilizados os modelos de alisamento exponencial e Box-Jenkins, os quais foram avaliados pelas métricas do Erro Quadrático Médio e da Média Absoluta Percentual de Erro.
Editorial
Authors: Almeida Josimar Ribeiro de
Published: September 2021

⠀⠀⠀⠀⠀⠀⠀⠀
Determinants of Social and Pedagogical Work with Involuntarily Displaced People in Higher Education Institutions
Authors:   MI ", Kvitko Natalia ,   Kharkiv Humanitarian and Pedagogical Academy",   of the Kharkiv Regional Council
Published: September 2021

Problems of internally displaced people are considered in this article. It has been defined that people from the east of Ukraine were involuntarily displaced because their relocation was carried out within one country due to the fear of becoming a victim of military conflict unlike refugees who have to leave their own country because of the fear to be chased by racial, religion or national reasons or because of belonging to a certain social group or political belief. It has been discovered that the main context of functions and different directions of social work with involuntarily displaced people consists in the support of complementary social environment or the change of social environment in direction of its greater complementarity for people who leave their home and fall into another social environment. It has been emphasized that the system of social and pedagogical work with such people in institutions of higher education has to be designed on the basis of formation and reconstruction of social qualities. It has been revealed that the context of social and pedagogical work with involuntarily displaced people in institutions of higher education will be effective in case it is carried out in such directions as social, social and psychological, social and pedagogical, social and legal, material, social and informational, and social an career-related. The summative stage of the research has been presented. It has given a picture of the level of satisfaction, trust, and attitude of internally displaced people regarding the solution of their problems in higher education institutions, and the reasons of their dissatisfaction with the received services in the institutions.
Political Persecution and Repression of Teachers of the Ukrainian SSR in the 1920 – 1930s
Authors:   State Institution Luhansk Taras Shevchenko National University, Bryvko Mykola
Published: September 2021

The research exposes the essence of political repressions of teachers as an important socio-professional group of society. It is based on the study of archival and criminal cases and other documentary sources of the Soviet totalitarian regime of the 1920 – 1930s. The analysed sources allowed proving the absurdity and criminality of the Soviet government in relation to the repressed educators, and they also helped to reveal the substantive features of the accusations, which varied at different times. In the 1920s, it was mainly connected with military service and the so-called «tsarist» or «bourgeois» education. Over time, the emphasis was shifted to non-proletarian social origins or nationalism. However, in the 1930s there was an expansion of accusations, in particular of Trotskyism, which from the mid-1930s was sometimes fused with Ukrainian or Polish nationalism. The article describes the main methods of political repressions. In particular, it is a method of creating non-existent «counter-revolutionary organizations» and a method of demonstrative trials, which were clearly displaying to society the «inevitability» of the struggle against «enemies of the people». In addition, more lenient methods of repression, such as the method of «cleansing» depending on social origin, political persecution and pressure through the media, and pedagogical certification of teachers, have been identified. The consequences of political repression of educators for Ukrainian education during the formation of the Soviet totalitarian regime in the 1920s and 1930s, and the prospects for further research have been outlined in the study.
Features of Use of Paradigmatic Approach in Research on History of Education and Pedagogical Thought
Authors:   State Institution Luhansk Taras Shevchenko National University, Vakhovskyi Leonid
Published: September 2021

The article identifies the features and substantiates the algorithm for using the paradigmatic approach in research on the history of education and pedagogical thought. In this regard, the concept of “pedagogical paradigm” is clarified, which is considered as a theoretical position or theory accepted by the scientific community as a standard, a model for solving research problems and capable of justifying and implementing a holistic model of education. It is shown that in the course of competition between different approaches to solving pedagogical problems the so-called binary oppositions are formed – polar points of view, and the opposition between them reflects the genesis of pedagogical theory within certain chronological frameworks. Attention is paid to quantization, which is the deployment of phases of the pedagogical paradigm. On this basis, the algorithm has been defined, i.e. the sequence of actions when applying the paradigmatic approach in research on the history of education and pedagogical thought, including: analysis of philosophical and pedagogical concepts, ideas, positions that led to qualitative changes in public education policy, theory and practice of education during the period under analysis; identification within the pedagogical concepts of binary oppositions – polar points of view on the essence of education, the criteria for selecting the content of education, forms and methods of educational activities; determining the impact of new pedagogical paradigms on mass educational practice.
The nursing associate in aesthetic practice
Authors: King Sharon
Published: September 2021

Sharon King discusses the role of the nursing associate within medical aesthetics
Softly, softly task force
Authors: Bernstein Adam
Published: September 2021

Adam Bernstein explains the definition and benefits of soft skills training, including how it benefits the wider teams and enables individuals to carry out their role more effectively
STRATEGIC MANAGEMENT BASED ON BUCKLEY'S FUZZY AHP AND SWOT: EXAMPLE OF THE CONGREGATION OF THE MISSIONARIES OF THE SACRED HEART
Authors: Ohoitimur Johanis , Krejci James , Raco Jozef Richard , Raton Yulius , Jamlean Anselmus , Welerubun Ignasius , Tanod Rafael
Published: September 2021

Strategic priorities are commonly implemented by both profit and non-profit institutions, but rarely employed by religious congregations. The congregation of the Missionaries of the Sacred Heart (MSC), an institution in the Catholic Church, has undertaken an empirical study, using a combination of SWOT and fuzzy-Analytic Hierarchy Process (AHP) methodologies. Four strategies were employed. First, the strategy S-O (30.1%), aimed at intensifying and improving our human resources in order to enrich the lives of all our members. Second, we adopted the strategy S-T (25.8%) that focused on our Sacred Heart Spirituality to empower the fraternal community. Third, we adopted the strategy W-T (24.1%) that aimed at strengthening the Sacred Heart Spirituality throughout the entire MSC family. Finally, we used the strategy W-O (20.1%) in order to strengthen networking in the congregation while also revitalizing family ministry. A sensitivity analysis confirmed the SO alternative as the main strategy. Internally, the congregation is quite strong but more needs to be done to deepen the Sacred Heart Spirituality among all our members. The researchers recommend conducting further study of the congregation about how they perceive the MSC pastoral ministry and understand the vision.
Report on an Analytic Network Process (ANP) Model to Estimate the Benefits, Opportunities, Costs, and Risks (BOCR) that Gun Policies and Violence Prevention Interventions have on Legal Users of Firearms
Authors: Vargas Luis G , Guiora Amos N. , Minutolo Marcel C.
Published: September 2021

Balancing public good with individual rights is a difficult task; gun policies attempt to do just this. To ensure public safety, local, state, and federal agencies piece together policies that each entity believes will meet the needs of public welfare. When legislating new gun policies, the impact the policies have on gun owners are perceived as a zero-sum game; some groups are perceived to gain while others think they are losing, but the reality is much more nuanced. 
 
The reason the impact of these policies on all lawful gun owners has been considered a zero-sum game is largely because to date there has been no research measuring the impact. Further, there have been no attempts to quantify the impact that the policies have on lawful gun owners. The sole argument that has been made is about constitutionality.
 
In this paper, we develop an approach based on the Analytic Hierarchy Process (AHP). The approach allows us to develop criteria for evaluating the impact of these policies on lawful gun owners and generate priorities for the criteria from pairwise comparisons. Criteria are compared in pairs, thus the term pairwise comparisons.  This allows us to score, as with a scorecard model, gun policies for various types of gun owners with respect to the criteria according to the Benefits, Opportunities, Costs, and Risks, thereby determining the impact of each policy.