bluuebunny/crossref_metadata_2025 huggingface dataset:
Роль уверенности и компетентности в социальной верификации суждений в условии диадного взаимодействия
Authors: Толстова Екатерина А. , Морошкина Надежда В.
Published: February 2025

Introduction. When making judgments under uncertainty, people often use social verification, i.e., comparing their judgments with the opinions of others. In some cases, social verification leads to increased accuracy of judgments (the "two heads are better" effect). However, to improve accuracy, it is important to take into account the partner's competence and current confidence in the answer. The ways in which confidence is conveyed in computer-mediated dyadic interaction situations are still poorly understood. The present study allowed us, for the first time, to isolate direct (confidence judgment) and indirect (response time) confidence transfer pathways and to test their effects on the success of social verification judgments in computer-mediated interaction. Methods. The experiment followed a between-subjects design, with groups differing in the way confidence was conveyed (direct / indirect). There were a total of 70 participants (50 females, 20 males) aged 18 to 33 years (M = 22.2, SD = 3.15). Participants worked in pairs at the same computer, with a non-transparent screen separating them so that they could not see each other. In the first stage, participants completed the reading experience test independently, and in the second stage they had the opportunity to compare their answers with a partner and to revise them. Between stages, information about the success (competence) of both participants was presented. Results. The concurrence of participants' responses increased significantly after they revised them. Confidence conveyed both indirectly and directly had a significant effect on the likelihood of response change. There was no significant effect of participants' relative competence. However, only the group with direct conveyed confidence significantly increased the accuracy of revised responses. Discussion. A possible explanation could be that accuracy is increased by orienting to the partner's confidence, which was easier to accomplish in the direct confidence transfer group. An alternative explanation may be that explicit confidence evaluation not only conveys information to the partner, but also helps the person themselves better understand where they are more likely to be wrong.
Психологические барьеры инклюзивного взаимодействия как фактор риска для учащихся начальных классов
Authors: Колокольникова Мария В. , Борозинец Наталья М. , Крыжевская Наталья Н. , Жикривецкая Юлия В.
Published: February 2025

Introduction. The risks of an inclusive educational environment are associated with the emergence of psychological barriers to the interaction of its subjects. In this study, we provided the results of cluster analysis characterizing the psychological barriers to interaction between students and teachers. Methods. The total number of subjects is 192 people (128 children aged 8–10 years (primary school students - both with disabilities and limited health, and ordinary children from educational organizations in Stavropol); 64 teachers of educational organizations (schools)). As the main method we used J. Kelly's method of repertory lattices. Factor, cluster and correlation analysis were used to process the obtained data. Results. As a result of the study, the presence and essence of psychological barriers to interaction in dyads of subjects of the inclusive educational process were revealed: teachers-children, children-children. The qualitative characteristics of psychological barriers in these dyads are shown in the context of the types of barriers we have identified: communicative, activity and personal. In the teacher-children dyad, all types of barriers were identified, the sources of which are the teachers themselves. In the child-child dyad, communication and activity barriers predominate. The degree of severity of psychological barriers to interaction among teachers is concentrated in the range from excessive to average, and in the sample of children from above average to low. Discussion. The results obtained were considered as risk factors for the safety of the educational environment. For subjects of the inclusive educational process, the presence of psychological barriers leads to risks that hinder the success of educational outcomes and social integration.
Investigação da infecção por leishmania spp. Em felinos domésticos (felis catus) na cidade de Mossoró, Rio Grande do Norte
Authors:   , Bezerra José Artur Brilhante
Published: February 2025

O objetivo do presente estudo foi investigar a ocorrência da infecção por
Leishmania spp. e a coinfecção pelo vírus da imunodeficiência felina (FIV) e o vírus da
leucemia felina (FeLV) em felinos domésticos provenientes de uma cidade endêmica no
estado do Rio Grande do Norte para a leishmaniose visceral canina e humana. Foram
incluídos no estudo 91 gatos. Esses animais foram submetidos a exame clínico completo e
amostras de sangue foram coletadas. Um questionário epidemiológico foi aplicado aos tutores
de cada animal para investigar fatores de risco. Anticorpos IgG anti-Leishmania spp. foram
avaliados por meio da imunofluorescência indireta (RIFI), adotando-se como ponto de corte a
diluição de 1:40. A reação em cadeia da polimerase (PCR) foi executada visando detectar o
material genético de Leishmania spp. a partir de amostras de sangue total. Também foi
executado um teste imunocromatográfico para avaliar a presença de anticorpos contra o FIV e
antígenos do FeLV. Observou-se soropositividade em 14 (15,38%), 26 (28,57%) e 3 (3,29%)
animais para Leishmania spp., FIV e FeLV, respectivamente. Nenhuma amostra foi positiva
na PCR de sangue total. Não foi observada nenhuma associação estatística entre a
soropositividade para Leishmania spp. e gênero, idade, presença de sinais clínicos e fatores de
risco avaliados. Dos 14 animais soropositivos para Leishmania spp., 5 apresentavam
anticorpos contra o FIV, porém não houve associação estatística entre as duas infecções (p =
0,052). Não houve coinfecção com o FeLV. Esses achados demonstram pela primeira vez que
os felinos da região estudada estão sendo expostos a esta zoonose e podem estar participando
de forma importante da cadeia epidemiológica de transmissão da leishmaniose visceral.
Dieta de lagartos e serpentes atropelados em rodovias do semiárido nordestino no estado do Rio Grande do Norte, RN
Authors:   , Cabral Sofia de Oliveira
Published: February 2025

Os estudos sobre a história natural de lagartos e serpentes ainda são escassos
para o bioma Caatinga, com descrições desagregadas e pontuais em tipos
diferentes de Caatinga. As diferentes espécies de lagartos e serpentes ocupam
diferentes posições no nível trófico e possuem grande importância no
diagnóstico de efeitos bióticos e abióticos sobre o ambiente. O presente foi
realizado através da necropsia dos animais mortos por atropelamento em
trechos de estradas circundantes a três Unidades de Conservação Federal:
Parque Nacional de Furna Feia, Floresta Nacional de Açu e Estação Ecológica
do Seridó. Os animais atropelados foram levados para o laboratório de
Ecologia e Conservação da Fauna Silvestre, na Universidade Federal Rural do
Semi-Árido, para identificação da espécie, morfometria e análise da dieta. O
objetivo geral do projeto foi caracterizar sazonalmente os hábitos alimentares
de diferentes espécies de lagartos e serpentes mortos por atropelamento. O
estudo das dietas possibilita uma maior amplitude acerca das informações não
apenas ecológicas, de comportamento e fisiológicas sobre as espécies
encontradas atropeladas. Essa abrangência de conhecimento contribui ainda
para que podem ser implantadas medidas de conservação para as espécies
estudadas.
Quantificação e qualificação de fraturas em pelve através da radiografia padronizada e oblíqua bilateral em cães e gatos politraumatizados
Authors:   , Oliveira Kalyne Danielly Silva de
Published: February 2025

Objetivou-se radiografar pela técnica padronizada (latero-lateral e ventro-dorsal) a pelve de cães e gatos politraumatizados e comparar com a técnica oblíqua bilateral (ventro-45 medial dorso lateral esquerda/direita flexionada) na avaliação de fraturas (completas e incompletas) e luxações (sacro-ilíaca e coxofemoral). Utilizou-se oito gatos e quatro cães, de idade, raça e peso variados. Após a obtenção das radiografias, as imagens foram avaliadas por dois radiologistas grupo controle, dois ortopedistas, dois residentes de diagnóstico por imagem e dois alunos. As imagens radiográficas foram distribuídas e avaliadas de forma aleatória. A análise realizada foi uma comparação de médias para dados não paramétricos através de um GLM levando em consideração o estatístico WALD e p˂0,05. Ao comparar o número total de fraturas completas e incompletas nas projeções ventro-dorsal (VD), latero-lateral (LL) e oblíqua (OBL), observou-se diferença estatística entre as três projeções LL, VD e OBL (N=288, df= 2, wald= 24,7 p= 0.0000), entre VD e OBL (N=288, df= 2, wald= 11,9 p=0,0005), entre LL e OBL (N=288, df= 2, wald = 24,0, p= 0,000001) demostrando que a projeção em que mais visibilizou fraturas foi a VD (n=188). As projeções OBL (n=174) e VD (n=188) visibilizaram mais do que a LL (n=105). Para avaliação de luxações sacro-ilíacas verificou-se que as projeções VD (n=33) e OBL (n=33) foram mais sensíveis quando comparada com a LL (n=0) (N= 288, df=2, Wald= 1964,2, P˂0,01-10 ). De modo geral, as anormalidades (fraturas e luxações) foram vistas com maior acurácia na vista VD (n=237), seguida pela vista OBL (n=225) (N= 288, df=2, Wald= 18,1, p=0,00002) e LL (n=120) (N= 288, df=2, Wald= 40,2, P˂0,01-10) sugerindo que a projeção LL possui pouca sensibilidade na avaliação de anormalidades na pelve de cães e gatos politraumatizados. Contudo, sugere-se que as projeções OBL sejam incluídas nos estudos da pelve, enquanto as projeções LL, sejam realizadas em casos de direcionamento das afecções na região lombosacra.
Output feedback fuzzy model predictive control applied to 3ssc boost converter
Authors:   , Moreira Thalita Brenna da Silva
Published: February 2025

The recent advance in the computational capacity of microprocessors has triggered an expansion of research and various applications of advanced control techniques. Considering this scenario, Model Predictive Control (MPC) and fuzzy control approaches gain prominence and popularity due to their attractive characteristics. These methods are capable of treating systems with con- straints, uncertainties in the model, non-linearities and external disturbances. Thus, considering the good attributes of these control methods, the objective of this work is to propose and analyze a control law which merge the characteristics of MPC and fuzzy control. The proposed method consists of an output fuzzy model predictive control (FMPC), in addition a Takagi-Sugeno (TS) fuzzy model and the Parallel-Distributed Compensation (PDC) method is used to define the con- trol law. In order to analyze the performance of the controller, two applications are run through computer simulation. First, the FMPC controller with output feedback is applied to a numerical example and then to a boost converter. Furthermore, the analysis is performed for the online and offline methodologies, with the online approach being compared with output feedback MPC found in the literature. The controllers are evaluated in terms of time response, pole allocation, performance indices and stability ellipsoids. For both applications the obtained results showed that the proposed controller solves the control problems efficiently, guaranteeing the stability and performance of the system even in the face of limiting situations such as: non-linearities, change in the operation point, input constraint and non-minimum phase
Imine Derivatives of Hydrochlorothiazide Bear Potential Diuretic Activity in in-vivo Experimental Model by Targeting Renal Outer Medullary Potassium Channel
Authors: Warda Hafiza Saliha , Sultana Kishwar , Ullah Irfan , Jan Afnan , Abdellattif Magda H. , Kashtoh Hamdy , Ur Rehman Najeeb , Khan Ajmal , Al-Harrasi Ahmed
Published: February 2025

Introduction:

This study involves several recently synthesized Schiff base derivatives
of hydrochlorothiazide (3a-3e), characterized by advanced spectroscopic techniques including
Fourier transform infrared (FTIR), 1H-, 13C-NMR (Nuclear magnetic resonance),
and High-resolution electrospray ionization mass spectrometry (HR-ESI-MS).

Method:

Hydrochlorothiazide (HCTZ, 2 mM) was mixed with 2 mM aldehydes in ethanol
(20 mL) in the presence of glacial acetic acid, and the product was stirred with the help of a
magnetic stirrer under the specified conditions. Keeping in mind the importance of imine
derivatives against DPPH radical, the synthesized compounds were evaluated for antioxidant
activity (in-vitro) using DPPH assay and diuretic activity (in-vivo) by Lipschitz
method. All derivatives demonstrated notable antioxidant activity, exhibiting 52-86% inhibition.

Result:

The compounds 3a-3e also displayed remarkable diuretic effects in an in-vivo model
at a dose of 50 mg/kg. The computational studies of all the newly synthesized compounds
were interpreted for the diuretic activity at the molecular level against human renal outer medullary
potassium channel (ROMK1, PDB: ID) protein present on the nephron involved in
diuresis indicating all compounds showed significant interactions at all receptors.

Conclusion:

As the derivatives were more active than drugs in some regards; therefore, these
derivatives will be beneficial and open new windows for research and additional pharmacological
screening could be planned as part of the project's extension.
Lipid Biochemistry and its Role in Human Diseases
Authors: Nehaoua Amine , Gasmi Amin , Benahmed Asma Gasmi , Noor Sadaf , Bjørklund Geir
Published: February 2025

Lipids play a variety of roles in living systems. They are a source of extremely
high energy and a part of almost all signaling and biological processes. Despite the liver
being the hub of lipid metabolism, lipid metabolism occurs across the human body.
Any perturbation in the lipid metabolism or lipid storage systems can lead to diseases or
disorders that can hamper the normal functioning of the human body. Lipids have been
explored for their role in cancers. The intake of saturated fatty acids has been found to increase
the metastasis and growth of cancerous cells. The role of lipids has also been
studied in brain diseases. In Tay-Sachs disease, the inability to metabolize GM2 ganglioside
alters normal nerve cell functioning. Similarly, lipids also play critical roles in
Parkinson's and Alzheimer’s disease. Moreover, atherosclerosis is a leading cause of cardiovascular
diseases and brain stroke. Dyslipidemia or excess fatty acids is a leading
cause of non-alcoholic fatty liver disease, insulin resistance, and diabetes mellitus. Dyslipidemia
also leads to jaundice, which, in turn, can seriously damage the kidneys. This
review focuses on the various human diseases occurring because of lipid metabolism.
The Multifaceted Roles of Thrombomodulin: Anti-coagulation, Anti-inflammation, and Anti-tumor Potential
Authors: Yang Jiaying , Gu Yongxing , Wang Tianyin , Zhang Jingjing , Zhang Xiong , Yu Feng
Published: February 2025

Thrombomodulin (TM) is a single-chain transmembrane glycoprotein with anticoagulant effects.
TM has two forms: membrane type existing on the cell surface and blood type free in plasma and urine. TM
functions as an anticoagulant cofactor for thrombin activation of protein C on the surface of vascular endothelial
cells. Due to the excellent anti-coagulant effects in modulating the coagulation and fibrinolytic system, the
recombinant human soluble TM (rhsTM) has been used for the treatment of disseminated intravascular coagulation
(DIC). In addition to anti-coagulation, many studies have shown that TM can also exert anti-inflammatory
and anti-tumor effects. TM has a lectin-like domain at its N-terminus that has been shown to exhibit direct
anti-inflammatory functions. At the same time, due to its special structure, thrombomodulin plays an important
role in vascular-related mechanistic diseases by participating in the regulation of inflammatory pathways,
complement, HMGB1, etc. In this article, changes in TM expression in the body after injury, composition of
TM structural domains, anticoagulant, anti-inflammatory, and antitumor effects, and related mechanisms of
TM were systematically reviewed, to provide a theoretical basis and reference for the potential clinical implications
of TM in treating various diseases.
A Review Unveiling the Ferroptosis-Regulated Cell Signalling Pathways in Breast Cancer to Elucidate Potent Targets for Cancer Management
Authors: Pandey Pratibha , Pandey Shivam , Ramniwas Seema , Ballal Suhas , Kumar Sanjay , Bhat Mahakshit , Sharma Shilpa , Kumar M. Ravi , Khan Fahad
Published: February 2025

Recent research suggests that targeting ferroptosis exhibits promise as a potent treatment approach
for breast carcinoma. Specific subtypes of tumor cells exhibit heightened vulnerability to ferroptosis-inducing
chemicals, which selectively trigger tumor stem cells' demise, enhance tumor cells' sensitivity to chemotherapeutic
drugs, and eliminate cancerous cells. Ferroptosis plays a dual role in breast cancer progression, emerging
as both a stimulating and inhibitory component. Ferroptosis is effective in treating cancer cells (mesenchymal
breast), identified by their ability to undergo Epithelial-mesenchymal Transition (EMT) and their resistance
to conventional therapies. Pharmaceutical drugs that hinder the activity of enzymes known as kinases,
which are involved in the AKT/mTOR/PI3K signaling pathway, have shown significant potential in the treatment
of breast carcinoma. This review investigates the molecular mechanisms of different signaling pathways
implicated in ferroptosis in breast carcinoma, with specific emphasis on metastasis, invasion, and proliferation.
Our study contributes to understanding a potentially important target that could be used in developing
therapeutic strategies for breast cancer treatment.
Hsa_circ_0030568 Promotes the Proliferation and Migration of Prostate
Cancer Cells via the miR-141-3p-BRD4 Axis
Authors: Sun Xiaoxiao , Xiang Congming , Wu Yuwei , Ge Dongsheng , Sun Chengwen
Published: February 2025

Introduction:

Numerous studies have indicated that circular RNAs (circRNAs) play
an important role in diverse cancers. However, the specific molecular mechanism of circRNAs
in prostate cancer (PCa) remains largely unclear.

Method:

In this study, we performed western blotting, real-time quantitative polymerase chain
reaction, CCK-8 assay, cell scratch wound assay, and RNA immunoprecipitation assay.

Results:

These results showed that the expression of hsa_circ_0030568 was remarkably increased in PCa cells by using quantitative real-time PCR combined with dataset analysis.
Mechanistically, circ_0030568 could physically bind to miR-141-3p and elevate the expression of
BRD4 via sponging miR-141-3p in PCa cells, then accelerating the progression of PCa. Upregulation of hsa_circ_0030568 induces tumor progression through the miR-141-3p-BRD4 axis.

Conclusion:

Taken together, these findings suggested that hsa_circ_0030568 may act as a potential biomarker of PCa and a promising target for PCa treatment.
Role of Immune Cells in Mediating the Causal Effect of Gut
Microbiota on Type 2 Diabetes
Authors: Ruifang Liu , Ruiting Chai , Zhaoyang Yang , Candong Li
Published: February 2025

Background:

Previous studies have suggested that gut microbiota and
immune system regulation have potential links with type 2 diabetes (T2D). However,
the causal association between gut microbiota and T2D and whether immune cells
mediate this interaction is unclear.

Methods:

A two-sample, two-step Mendelian randomization (MR) study utilizing an
initial inverse-variance weighted (IVW) method was performed to explore the causal
impact of gut microbiota on T2D and the intermediary role of immune cells.

Results:

The MR analysis assigned 4 gut microbiota and metabolic pathways that
increase the risk of T2D (G_Prevotella, g_Anaerotruncus, g_Streptococcus.s_
Streptococcus_parasanguinis, and the pathway of PANTO-PWY) and 4 other gut
microbiota and metabolic pathways that have a protective effect against T2D (PWY5667, PWY-6892, PWY-7221, and the bacterial g_Paraprevotella.s_Paraprevotella_
clara). Furthermore, 17 immune cell traits have been identified as associated with T2D.
The finding from mediation MR analysis revealed that PANTO-PWY increases T2D
risk via CD3 on HLA DR+ CD4+, whereas PWY-7221 reduces T2D risk through CD4
on CD4 Treg.

Conclusion:

The research reveals a mediated causal link between the gut microbiota
and T2D via immune cells.
Synthesis of Novel 3-spirocephalosporins and Evaluation of their
Antibacterial Activity
Authors: Zwayyer Noor H. , Muhsen Usama A. , Faraj Rawah , Abebe Woubit
Published: February 2025

Background and Objective:

Despite the well-known antibacterial activity of
cephalosporins, their analogous spirocyclic derivatives have not been adequately evaluated.
Thus, this work aimed to prepare a series of novel 3-spirocephalosporins and evaluate their
antibacterial activity.

Materials and Methods:

Novel 3-spirocephalosporins were prepared through a one-pot thioalkylation of chloromethyl cephalosporin GCLE with a range of 1,2,4-triazolidine-3-
thiones, followed by intramolecular Michael addition to the generated dihydrothiazine ring.
The reaction was performed at room temperature under basic conditions (K2CO3, acetone,
H2O). The antibacterial activities of the synthesized compounds were evaluated against a
panel of Gram-positive and Gram-negative bacteria

Results:

Most targets were obtained in moderate yield, and their structures were confirmed
by 1H and 13C NMR spectral techniques. All the tested compounds exhibited antibacterial
activity against methicillin-resistant S. aureus

Conclusion:

Seven novel thiazolidine-bearing 3-spirocephalosporins were prepared, and
most of them were potent against Gram-positive bacteria. Likely, the replacement of 1,2,4-
triazolidine-3-thiones with other heterocycles containing bidentate nucleophiles in advantageous positions could lead to different biologically active spirocephalosporins.
A Systematic Review and Meta-analysis on the Safety and Efficacy of CAR T Cell Therapy Targeting GPRC5D in Patients with Multiple Myeloma: A New Insight in Cancer Immunotherapy
Authors: Robat-Jazi Behrouz , Mahalleh Mehrdad , Dashti Mohsen , Nejati Negar , Ahmadpour Mahsa , Alinejad Erfan , Mohammadi Shiva , Lorestani Parsa , Hamidieh Amir Ali , Habibi Mohammad Amin , Jadidi-Niaragh Farhad
Published: February 2025

Background:

Despite ongoing advances and introducing innovative therapeutic approaches for the
treatment of multiple myeloma (MM), relapses are common, with low overall survival rates. G protein–coupled
receptor, class C, group 5, and member D (GPRC5D) has been expressed in several myeloma cell lines and has
demonstrated encouraging outcomes results in in-vitro studies as a potential target for immunotherapies.

Objective:

We aimed to investigate the safety and efficacy of GPRC5D-targeted CAR T cell therapies in MM
patients.

Methods:

On August 24, 2023, the databases of PubMed, Scopus, Embase, and Web of Science were systematically
searched for pertinent studies. After completing a two‐step title/abstract and full-text screening process, the
eligible studies were included.

Results:

Following the screening of 107 articles, four studies of 130 multiple myeloma patients treated with
GPRC5D-targeted CAR T-cell therapy were included. The meta-analyses showed an ORR of 87% (95% CI [81-
93%]), with 74% (95% CI [65-73%]) for those with prior BCMA-targeted therapy and 88% (95% CI [78-99%])
for those without. PR was 25%, VGPR 33%, and CR/sCR 48%, with 65% achieving MRD-negativity. In terms of
safety, hematologic AEs were common, with anemia reported in 86% of patients. Non-hematologic common AEs
included CRS (83%, 5% grade ≥3) and hypocalcemia (63%, 10% grade ≥3). No significant publication bias was
detected.

Conclusion:

GPRC5D is an active and safe target that shows promising results in the treatment of relapsed and/or
refractory (R/R) MM and heavily pretreated patients.
Evaluation of Toxoplasma gondii Perforin-like Proteins (PLPs) to Find the
Potential Epitopes for Immunization through in silico Approach
Authors: Hosseini Seyyed Amir , Safari Mohamad Hosein , Siamian Davood , Majidiani Hamidreza , Basati Gholam , Asghari Ali
Published: February 2025

Background:

Toxoplasma gondii (T. gondii) is a widespread apicomplexan parasite
that affects approximately one-third of the global population, posing particular risks to pregnant
women and individuals with weakened immune systems. Despite its significant impact, there is
currently no vaccine available for humans.

Objective:

This study employs computational methods (in silico) to investigate the physicochemical, antigenic, and structural properties of Perforin-like proteins (PLPs) from T. gondii, as well as
to identify immunogenic epitopes within these antigens.

Methods:

For this aim, amino acid sequences of TgPLP1 and TgPLP2 were retrieved and submitted to the ProtParam (physicochemical), VaxiJen v2.0 (antigenicity), NetSurfP-6.0 (2D structure),
Robetta (3D structure) web servers, along with the IEDB server to decipher the immunogenic epitopes. Subcellular characteristics such as signal peptide, transmembrane domain, post-translational modifications (PTMs), and cellular localization were also predicted.

Results:

Both proteins had a high MW of 125.50 and 92.21, respectively, with an alkaline pI, a 30
hours half-life in mammalian reticulocytes, good thermotolerance (high aliphatic index), and hydrophilicity properties (negative GRAVY). They also showed good antigenicity (0.7021 [PLP1]
vs 0.5701 [PLP2]), while they were non-allergenic. Both proteins were extracellular with numerous post-translational modification sites (phosphorylation, glycosylation, and acetylation), and a
transmembrane domain was only present in TgPLP1, with no signal peptide in both. Furthermore,
numerous immunogenic B- and T-cell epitopes were identified within the TgPLPs sequences,
suggesting their potential for inclusion in multi-epitope vaccine designs.

Conclusion:

Further studies are needed to confirm these findings and assess the efficacy of the
proposed vaccine constructs.
A study of lesson design strategies to promote regulated learning in science considering the social context
Authors: Wada Ichiro
Published: February 2025

Going beyond merely imparting information and actually equipping children with the skills to engage in scientific enquiry is important. This is a focus area in Japan, through which scientific literacy and critical thinking in education can be improved. With the right environment, children
can be encouraged to pursue self-driven inquiry, reflect on their learning and collaborate with their peers. Professor Ichiro Wada, Division of Advanced Professional Practice in Education, Yokohama National University who is interested in improving children’s ability to
regulate their own learning based on metacognition and the right environment for this to happen. His current research concerns how the regulation of learning is established within a social context and he is homing in on three important concepts: self-regulation (SRL); co-regulation (CoRL);
and socially shared regulated learning (SSRL). Focusing on these types of regulation, Wada and his collaborators developed and examined a science lesson design strategy integrating instruction and evaluation to develop children's ability to solve problems independently and collaboratively.
The researchers found that the children's metacognition function was a hub which connected them to one another and enhanced their function through interaction with others. They also discovered that the teacher's feedback function was promoted by the children's evaluation and judgement. This
work enabled Wada to capture the interrelated cognitive, metacognitive and motivational variables of these concepts. He has modelled the formation of the internal structure and interaction processes. A key current focus for Wada is evaluative judgement, which requires children to have their
own evaluative criteria related to the selection and choosing of information.
The effect of Guizot’s thought on Japan in the end of Edo period ‐ how his essay on civilization had come to Japan globally
Authors: Kawata Atsuko
Published: February 2025

Professor Atsuko Kawata, Faculty of Contemporary Life Sciences, Tokyo Kasei Gakuin University, Japan, is exploring the nation’s (public) power impacts of different individuals on a country’s citizens, including how they affect societal structures and gender roles, especially
through educational system. During her PhD studies, Kawata discovered Naito Masu; a pioneer of women’s education in Yamanashi Prefecture in the Meiji period. A woman occupying a leading role in education was unusual for the time, which fascinated Kawata. Masu challenged the beliefs of
the time, which were that Japanese women didn’t need knowledge or education, and set about championing for change. During her research on Masu, Kawata also discovered that in the Meiji period people believed that neither state nor religious power should subordinate the inner self of
human beings. This sparked an interest in uncovering how this belief entered society and this led to Kawata’s current research on unpicking the gender structure that has come about since the Meiji period in modern Japan and the influence of French politics and governance. Kawata looked
at the introduction of French law at the beginning of the Meiji period. She also began investigating the influence of French Minister of Public Education François Guizot ‐ and his desire to civilise Asia ‐ on Japan. She is exploring the impact of his thought,
including his beliefs about civilisation, which influenced on the concepts of ‘Oyake’ (public) and ‘Watakushi’ (private), in Japan.
Development of new teaching materials that reduce the burden on elementary school teachers and encourage students to take an active role in chemical experiments
Authors: Taneda Masatsugu , Asaka Noriko , Sakaguchi Ryutaro , Gung Andrew
Published: February 2025

There is a need for STEM (Science, Technology, Engineering and Maths) skills in job markets worldwide and therefore a growing emphasis is being placed on these subjects in schools. This requires the right education in terms of lessons for students and also training for teachers. Associate
Professor Masatsugu Taneda, Department of Science Education, Osaka Kyoiku University, is interested in how proper training could equip teachers without STEM backgrounds with the skills they need to enhance the education they are providing to students. He is developing quality education materials
to assist teachers and inspire students. Drawing on his background in chemistry, Taneda is focusing on chemistry experiments but the project has scope to be rolled out to other STEM subjects. In one study, he developed labware and digital teaching materials for on-demand chemistry experiments
that can be carried out at home. This enhances accessibility and flexibility for students while also improving standardisation of education. The digital teaching materials have been tested by student teachers affiliated with Osaka Kyoiku University who were given a lab kit containing the materials
needed for the experiments. Given that teachers in Japan often don’t have sufficient time to source new teaching materials, this enables teachers to focus on their role as education facilitators, while practical content can be prepared by STEM professionals. Taneda developed the toolkit
in collaboration with Kenis Corporation. The kits were evaluated for safety and content and then rolled out to university students not majoring in scientific fields so that they could be evaluated in the context of no scientific background.
Revitalising education through an interuniversity arrangement
Authors: Nakano Mika
Published: February 2025

Fair, open and inclusive discussions are key to ensuring voices are heard. This is integral to effective human communication, as is actively involving participants in deciding on group discussion rules. Professor Mika Nakano from the Centre for Liberal Arts at Fukuoka Institute of Technology
believes that in Japan, the adherence of social norms to traditional, established patterns is hindering society. She believes that entrepreneurship education will empower young people and ultimately improve society. She and her colleagues are creating a network of 18 universities in the Kyushu-Okinawa
region. Through this interuniversity arrangement, she wants to revitalise education. Part of this work is developing remote discussion skills in Japanese university students, which Nakano believes is currently lacking. Through her research, she wants to level the playing field when it comes
to economic, digital and social disparities between children. Her vision is a society where there are opportunities for everyone and one in which collaboration is inclusive. Nakano is also interested in argumentation as an education method, through which participants can respectfully share
ideas and viewpoints. She is developing a curriculum that utilises quantitative and qualitative approaches drawn from psychology and anthropology methodologies. This incorporates observation, questionnaire and interview methods to propose effective learning methods that will be tested to verify
their effectiveness.
Development of myocardial oxygen consumption index using non-invasive continuous blood pressure monitor and practical application of optimal exercise prescription algorithm
Authors: Suematsu Yasunori
Published: February 2025

Cardiology is a crucial speciality given the prevalence of cardiovascular disease. As weight gain and a sedentary lifestyle are major factors associated with heart disease, many prevention efforts and treatment strategies centre on exercise. Associate Professor (Lecturer) Yasunori Suematsu
is a cardiologist based at Fukuoka University Hospital who is working to optimise exercise therapy for patients in the rehabilitation phase of treatment. Suematsu is developing a myocardial oxygen consumption index using a non-invasive continuous blood pressure monitor and working on an optimal
exercise prescription algorithm to assist in the post-recovery treatment of his patients. As optimal exercise intensity varies depending on the day and factors such as physical condition, pathological condition, mental state, recovery and autonomic nerve activity, the programme that Suematsu
is developing enables individuals to easily measure their optimal exercise intensity for the day. This means that they can exercise at the most beneficial intensity for them every day. When it comes to data collection for the programme, he is interested in the product of systolic blood pressure
and heart rate, called the double product, which enables him to evaluate the anaerobic metabolic threshold. His new technique enables this to be measured accurately and non-invasively using a device called a continuous sphygmomanometer, which can continuously measure blood pressure. The researchers
are using this to develop a new myocardial oxygen consumption marker using the double product as a reference.
Decision-making process regarding safety and crisis management for childcare workers: Focusing on food allergy management
Authors: Tamura Kayo
Published: February 2025

When it comes to childcare, parents want to rest assured that, in their absence, their children are being provided with engaging activities, balanced nutrition and safety. Awareness of food allergies is key in childcare settings but most childcare workers don’t have
medical backgrounds and therefore staff training on food allergies and related crises is imperative. Kayo Tamura is a former childcare worker and lecturer at Aichi Gakusen University in Japan who is developing guidelines for decision making processes for food allergy and crisis management
for childcare workers. Guidelines were implemented by the Japanese Government following incidents involving allergies and school lunches in 1988 and 2012. However, Tamura is concerned that some teachers and childcare workers may be unable to implement these, meaning that accidents will continue
to occur. Therefore, she is working with childcare providers to better understand how guidelines and training are received and implemented in childcare settings. In order to assess how much knowledge about food allergies and sense of crisis awareness students have developed by graduation,
Tamara conducted a questionnaire survey of university students studying childcare. She also conducted a survey using the same questions, this time posed to childcare workers and performed a statistical analysis of the results. She found that many students already had some awareness of food
allergies, often through personal experience but they acquired more specialist knowledge through university by reviewing government guidelines and manuals and through childcare training.
The impact of the introduction of industrial robots on workplace injury risk and mortality
Authors: Yoshida Masahiro
Published: February 2025

In the 19th century, the Luddites protested against the introduction of new technology into the wool and cotton industries, concerned that this would mean a reduction in the quality of their work, less need for their skill and a lower pay. Nowadays, luddite is used to refer to someone
who dislikes technology. In modern society, there are similar concerns regarding artificial intelligence (AI) and what its introduction and evolution means for the human workforce. Despite these fears of past and present society, there is no doubt that there are significant benefits associated
with the introduction of new technologies. For example, industrial robots play an important role in reducing workplace injury and mortality risk. Associate Professor Masahiro Yoshida, Department of Political Science and Economics, Waseda University, Japan has a background in economics and
is interested in the socio-economic drivers and impacts of injuries in the workplace. While the nationwide injury rate improved before the Great Recession, it subsequently began to stagnate. Given accelerated investment in industrial robots, Yoshida found this puzzling and, through his work
in this area, found that most industrial robots are utilised in innately safe sectors rather than in more risky sectors, suggesting a profit-seeking reasoning behind investment in robots rather than the prioritisation of workplace safety. He also found that these sectors tend to have a higher
dependency on immigrants. This led Yoshida to explore the relationship between the dependency on immigration and the progress of robot adoption across industries.
Research on logistics that considers the working environment of truck drivers during the COVID-19 pandemic
Authors: Suzuki Kuninori
Published: February 2025

Logistics concerns organisational planning, implementation and operations and plays an important role in the supply chain. During the COVID-19 pandemic, many supply chains broke down and goods became difficult to procure. The crisis underlined the importance of logistics. Professor
Kuninori Suzuki, Nihon University, is a leader in the field of logistics who has authored well respected and highly read books that have been translated into different languages. He is currently conducting research on how the pandemic impacted the working environment of truck drivers. He is
developing a logistics system that can deal with the shortage of truck drivers that keeps digital transformation (DX) in mind. By utilising AI to optimise operation scheduling, Suzuki wants to improve productivity in the loading and unloading of goods. He is also using AI to clarify the criteria
for making decisions for return cargo and making recommendations on handling goods on a pallet-by-pallet basis. The goal is the development of a freight transport model that minimises the burden on truck drivers. A key focus for Suzuki is the food and beverage industry as this sector was most
affected during quarantine, forcing significant changes on how food and drink is moved through supply chains. He utilises statistical processing and numerical analysis through computer simulations in his work. There is a focus on collaboration, including in-lab discussions with colleagues
and feedback on the issues facing the companies with whom they are partnering. Suzuki set out to verify if the large-scale introduction of unmanned transport forklifts would reduce labour costs and improve the quality of unloading and loading.
The Nationalism of Sensibility from the Viewpoint of Meiji Art and Literature: Sublime Land and Picturesque Landscape
Authors: Morimoto Takako
Published: February 2025

Associate Professor Takako Morimoto, Department of Language and Culture, Shizuoka University, Japan, is exploring modern Japanese literature and Meiji landscape literature education to answer questions about the relationship between individuals and society. She is interested in how
individuals relate to the times and society in which they are in and how they challenge the related constraints. She believes modern Japanese literature and Meiji landscape literature education may hold the answers. She is exploring nationalism in the Meiji period, during which time Shigetaka
Shiga’s ‘Japanese Landscape Theory’ brought about a sense of nationalism that transformed into patriotic nationalism used to constrain people. A key part of Morimoto’s research is nationalism related to the ‘sublime-picturesque’ aesthetic found in the 18th
and 19th centuries in Western Europe. The ‘sublime’ is a concept which originated in Edmund Burke’s 1757 book ‘A Philosophical Enquiry into the Origin of Our Ideas of the Sublime and Beautiful’. She has found that nationalism is not necessarily formed only from
a national system consisting of laws and institutions, it is formed from the complementary relation between a national system and national sensitivity. She wants social sciences and humanities researchers to further explore this idea, prompting recognition of the complementary nature of the
two fields. She wants her readings of Tōson’s ‘Hakai’ and Sōseki’s ‘Gubijinso’ to spark further academic conversations.
John Barton and debates on economic policy in the first half of nineteenth century England
Authors: Ishii Jou
Published: February 2025

Professor Jou Ishii from the College of Economics, Kanto Gakuin University in Japan is an expert in the history of economics. He is building on his knowledge on economic thought to expand understanding on the social security of citizens. He is interested in expanding his knowledge on
19th century English economist John Barton. Barton studied the effects of the introduction of machinery during the period when the term ‘Luddite’ was coined, referring to English textile workers who rioted and destroyed machinery, believing it to be a threat to their jobs. Ishii
is studying Barton’s thoughts on the issue of economic policy in the first half of the 19th century in England to fill gaps in knowledge and further expand understanding of Barton’s progressive thoughts. Ishii’s focus is on Barton’s thoughts on economic policy, specifically,
with a view to thoroughly evaluating him and his thoughts. Ishii is also exploring debates on policy issues in the first half of the 19th century with consideration of the influence of classical political economy on the modernisation and westernisation of Japan after the second half of the
19th century. Ishii was initially interested in how small riots grew to become nationwide movements, but later interested in the economic and social structure underlying them. He is also exploring the difference between the situation in England and Japanese society, which had gone through
a process of modernisation in the second half of the 19th century without overcoming the semi-feudal system of land ownership.
The Rise of the Cotton Monopoly of Himeji Domain and its Historical Significance: A Comprehensive Study
Authors: Yamasaki Yoshihiro
Published: February 2025

Many researchers have explored the cotton monopoly system of the Himeji Domain. Traditional research on this and other monopoly systems typically takes an economic history perspective. An important historical point is how the monopoly system came to be, and this is yet to be clarified.
A team of researchers led by Associate Professor Yoshihiro Yamasaki at the School of Motivation and Behavioural Science at Tokyo Future University in Japan is investigating in detail how the cotton monopoly system was established, with a focus on the officials who led the cotton monopoly system
into reality in local communities. The expectation is that this research will enrich studies on monopoly systems in other domains, filling gaps in knowledge and understanding. In the Edo period, under monopoly systems, feudal domains monopolised the production and sale of specific products
to overcome financial difficulties. The domains purchased and sold all the products produced within their territories, and the profits were used as income for the domains. This was also the case with the Himeji domain’s monopoly system. Monopoly systems were largely implemented as part
of the reforms of domain government in the mid-to-late Edo period. Yamasaki believes the monopoly system was an economic policy and that understanding the historical significance requires consideration from a political standpoint. Yamasaki elected to analyse the cotton monopoly system, developed
by the Himeji domain as the policy body, from a multifaceted perspective, focusing on the standpoint of not only economic history but also political history as well as regional history.
Development research of arithmetic and mathematics curriculum incorporating revolutionary and cumulative knowledge growth
Authors: Ikeda Toshikazu
Published: February 2025

The continuous development of education is important in order to ensure it keeps growing and improving. Professor Toshikazu Ikeda, College of Education, Yokohama National University, Japan, is a Professor of Mathematics who is a proponent of revolutionary knowledge growth through overturning,
expanding, and integrating acquired knowledge and skills. This is about progression through bridging the gap between a knowledge goal and the existing knowledge base through developing techniques and pathways to that goal. Ikeda believes that by inserting revolutionary knowledge growth into
the mathematics curriculum in Japan, children can be encouraged towards more independent and problem solving based thinking. He has performed an analysis of current teaching materials which involved examining local teaching materials in a specific area, using lessons to analyse and evaluate
those materials and looking at long-term global teaching materials that give a deeper examination of specific topics, focusing on how and where it can be used and how students react to the content. In his work, Ikeda uses modelling as a problem solving tool and to develop techniques to deepen
learning and lead to revolutionary knowledge growth. Ikeda is collaborating with Professor Max Stephens, Melbourne University, to produce lectures centred on revolutionary growth knowledge for students at teacher training colleges. A key part of Ikeda's work is teaching
mathematical modelling in order to help students understand the importance of mathematics and develop their abilities.