bluuebunny/crossref_metadata_2025 huggingface dataset:
Phage Therapy, a Salvage Treatment for Multidrug-Resistant Bacteria Causing Infective Endocarditis
Authors: Hetta Helal F. , Rashed Zainab I. , Ramadan Yasmin N. , Al-Kadmy Israa M. S. , Kassem Soheir M. , Ata Hesham S. , Nageeb Wedad M.
Published: October 2023

Infective endocarditis (IE) is defined as an infection of the endocardium, or inner surface of the heart, most frequently affecting the heart valves or implanted cardiac devices. Despite its rarity, it has a high rate of morbidity and mortality. IE generally occurs when bacteria, fungi, or other germs from another part of the body, such as the mouth, spread through the bloodstream and attach to damaged areas in the heart. The epidemiology of IE has changed as a consequence of aging and the usage of implantable cardiac devices and heart valves. The right therapeutic routes must be assessed to lower complication and fatality rates, so this requires early clinical suspicion and a fast diagnosis. It is urgently necessary to create new and efficient medicines to combat multidrug-resistant bacterial (MDR) infections because of the increasing threat of antibiotic resistance on a worldwide scale. MDR bacteria that cause IE can be treated using phages rather than antibiotics to combat MDR bacterial strains. This review will illustrate how phage therapy began and how it is considered a powerful potential candidate for the treatment of MDR bacteria that cause IE. Furthermore, it gives a brief about all reported clinical trials that demonstrated the promising effect of phage therapy in combating resistant bacterial strains that cause IE and how it will become a hope in future medicine.
Clinical Outcomes of Patients with Chronic Neuropathic Form of Gaucher Disease in the Spanish Real-World Setting: A Retrospective Study
Authors: Stanescu Sinziana , Correcher Medina Patricia , del Castillo Francisco J. , Alonso Luengo Olga , Arto Millan Luis Maria , Belanger Quintana Amaya , Camprodon Gomez Maria , Diez Langhetée Lydia , Garcia Campos Oscar , Matas Garcia Ana , Perez-Moreno Jimena , Rubio Gribble Barbara , Visa-Reñé Nuria , Giraldo-Castellano Pilar , O’Callaghan Gordo Mar
Published: October 2023

This was a retrospective, multicenter study that aimed to report the characteristics of type 3 Gaucher disease (GD3) patients in Spain, including the genotype, phenotype, therapeutic options, and treatment responses. A total of 19 patients with GD3 from 10 Spanish hospitals were enrolled in the study (14 men, 5 women). The median age at disease onset and diagnosis was 1 and 1.2 years, respectively, and the mean age at follow-up completion was 12.37 years (range: 1–25 years). Most patients exhibited splenomegaly (18/19) and hepatomegaly (17/19) at the time of diagnosis. The most frequent neurological abnormalities at onset were psychomotor retardation (14/19) and extrinsic muscle disorders (11/19), including oculomotor apraxia, supranuclear palsy, and strabismus. The L444P (c.1448T>C) allele was predominant, with the L444P (c.1448T>C) homozygous genotype mainly associated with visceral manifestations like hepatosplenomegaly, anemia, and thrombocytopenia. All patients received enzyme replacement therapy (ERT); other treatments included miglustat and the chaperone (ambroxol). Visceral manifestations, including hepatosplenomegaly and hematological and bone manifestations, were mostly controlled with ERT, except for kyphosis. The data from this study may help to increase the evidence base on this rare disease and contribute to improving the clinical management of GD3 patients.
Traumatic Fracture Treatment: Calcium Phosphate Bone Substitute Case–Control Study in Humerus, Radius, Tibia Fractures—Assessing Efficacy and Recovery Outcomes
Authors: Knapp Gero , Pawelke Jonas , Heiss Christian , Elmas Sera , Vinayahalingam Vithusha , ElKhassawna Thaqif
Published: October 2023

To date, insufficient investigation has been carried out on the biocompatibility of synthetic bioactive bone substitute materials after traumatically induced bone fractures in clinical conditions. This study encompasses the safety, resorption, healing process, and complications of surgical treatment. Our current hypothesis posits that calcium phosphate-based bone substitutes could improve bone healing. In this retrospective case–control study, over 290 patients who underwent surgical treatment for acute fractures were examined. Bone defects were augmented with calcium phosphate-based bone substitute material (CP) in comparison to with empty defect treatment (ED) between 2011 and 2018. A novel scoring system for fracture healing was introduced to assess bone healing in up to six radiological follow-up examinations. Furthermore, demographic data, concomitant diseases, and complications were subjected to analysis. Data analysis disclosed significantly fewer postoperative complications in the CP group relative to the ED group (p < 0.001). The CP group revealed decreased risks of experiencing complications (p < 0.001), arthrosis (p = 0.01), and neurological diseases (p < 0.001). The fracture edge, the fracture gap, and the articular surface were definably enhanced. Osteosynthesis and general bone density demonstrated similarity (p > 0.05). Subgroup analysis focusing on patients aged 64 years and older revealed a diminished complication incidence within the CP group (p = 0.025). Notably, the application of CP bone substitute materials showed discernible benefits in geriatric patients, evident by decreased rates of pseudarthrosis (p = 0.059). Intermediate follow-up evaluations disclosed marked enhancements in fracture gap, edge, and articular surface conditions through the utilization of CP-based substitutes (p < 0.05). In conclusion, calcium phosphate-based bone substitute materials assert their clinical integrity by demonstrating safety in clinical applications. They substantiate an accelerated early osseous healing trajectory while concurrently decreasing the severity of complications within the bone substitute cohort. In vivo advantages were demonstrated for CP bone graft substitutes.
Assessing Phase-Change Materials as Effective Long-Term Biosensors in Limb Prosthetics
Authors: Johnston Robert , Sell Danielle , Fiedler Goeran , Singh Anita
Published: October 2023

Monitoring and controlling the microclimate at the skin–socket interface of limb prostheses is an important, yet unresolved, clinical problem. Phase-change materials (PCMs) represent a promising biosensor technology that holds the potential to both detect and alter (i.e., stabilize) changes in the temperature of a hybrid biological/mechanical system, such as a prosthesis. The biologically inspired sensor capabilities of PCMs can enhance the internal socket conditions and offer improved comfort and suspension while minimizing skin injuries for prosthesis users. This study investigated how prosthetic liners equipped with PCM biosensors affected the long-term outcomes for prosthesis users. In this double-blinded longitudinal crossover study, a cohort of transtibial prosthesis users wore regular conventional liners for six months and PCM liners for another six months. Prosthesis utilization, physical performance, and gait symmetry were studied using Modus StepWatch, the 2-minute walk test, and the TekScan F-Scan gait test, respectively. Measured parameters from these various tests, acquired at multiple timepoints during the study, were compared pairwise between the two liners per individual. While the obtained quantitative data trends, such as the gait symmetry, favored the PCM liners, no statistically significant differences were found between the PCM and conventional gel liners in any of the study parameters.
The Impact of Chronic Stress on Behavior and Body Mass in New Animal Models
Authors: Alexa Anisia Iuliana , Zamfir Carmen Lăcrămioara , Bogdănici Camelia Margareta , Oancea Andra , Maștaleru Alexandra , Abdulan Irina Mihaela , Brănișteanu Daniel Constantin , Ciobîcă Alin , Balmuș Miruna , Stratulat-Alexa Teodora , Ciuntu Roxana Elena , Severin Florentina , Mocanu Mădălina , Leon Maria Magdalena
Published: October 2023

(1) Background: Exposure to different sources of stress can have a significant effect on both psychological and physical processes. (2) Methods: The study took place over a period of 34 days and included a total of 40 animals. Regarding the exposure to chronic stressors, we opted for physiological, non-invasive stressors, e.g., running, swimming, and changes in the intensity of light. An unforeseen stress batch was also created that alternated all these stress factors. The animals were divided into five experimental groups, each consisting of eight individuals. In the context of conducting the open field test for behavioral assessment before and after stress exposure, we aimed to investigate the impact of stress exposure on the affective traits of the animals. We also monitored body mass every two days. (3) Results: The control group exhibited an average increase in weight of approximately 30%. The groups exposed to stress factors showed slower growth rates, the lowest being the running group, recording a rate of 20.55%, and the unpredictable stress group at 24.02%. The anxious behavior intensified in the group with unforeseen stress, in the one with light variations, and in the running group. (4) Conclusions: Our research validates the animal model of intermittent light exposure during the dark phase as a novel method of inducing stress. The modification of some anxiety parameters was observed; they vary according to the type of stress. Body mass was found to increase in all groups, especially in the sedentary groups, likely due to the absence of cognitive, spatial, and social stimuli except for cohabitation.
The Profiles and Antecedents of Supervisor-Directed Emotional Labor Strategies: The Role of Self-Identity and LMX Orientations in Emotional Labor Strategy
Authors: Wang Ranran , Kim Sang-Joon , Kwon Insu
Published: October 2023

This study has two purposes. The first is to determine whether subordinates employ alternative combinations of emotion regulation strategies toward their supervisors beyond merely using surface and deep labor from the person-centered perspective. The second purpose is to understand why such acts of emotion regulation occur in interactions between employers and employees in the typical workplace. Utilizing latent profile analysis on data from 232 office employees in Beijing, China, collected using a two-stage sampling technique, four distinct supervisor-directed emotional labor profiles (i.e., deep actors, non-actors, moderators, and regulators) are identified. We find that these profiles are differentiated by several factors (i.e., individual identity, relational identity, and LMX orientations). Moreover, our findings suggest that employees exhibiting high levels of relational identity are more predisposed to act as deep actors, whereas individuals with high levels of individual identity are prone to being regulators as opposed to becoming deep actors, non-actors, or moderators. In addition, our results also suggest that LMX orientations have moderating effects on the relationships between self-identities and supervisor-directed emotional labor strategies. Overall, the results of this study expand the potential dimensionality of supervisor-directed emotion regulation strategies (e.g., regulating and non-acting) and bridge a gap in our understanding of the factors impacting supervisor-directed emotional labor.
Dose Consideration of Lenvatinib’s Anti-Cancer Effect on Hepatocellular Carcinoma and the Potential Benefit of Combined Colchicine Therapy
Authors: Lin Zu-Yau , Yeh Ming-Lun , Liang Po-Cheng , Hsu Po-Yao , Huang Chung-Feng , Huang Jee-Fu , Dai Chia-Yen , Yu Ming-Lung , Chuang Wan-Long
Published: October 2023

Purpose: The dose-dependent anti-cancer effect of lenvatinib on hepatocellular carcinoma (HCC) cells and the potential benefit of combined colchicine therapy were investigated. Methods: Four primary cultured HCC (S103, S143, S160, S176) cell lines were investigated by differential expressions of genes (11 lenvatinib target genes and NANOG) and anti-proliferative effect using clinically achievable plasma lenvatinib (250, 350 ng/mL) and colchicine (4 ng/mL) concentrations. Results: Colchicine showed an anti-proliferative effect on all cell lines. Lenvatinib at 250 ng/mL inhibited proliferation in all cell lines, but 350 ng/mL inhibited only three cell lines. For lenvatinib target genes, colchicine down-regulated more genes and up-regulated less genes than lenvatinib did in three cell lines. Lenvatinib up-regulated NANOG in all cell lines. Colchicine down-regulated NANOG in three cell lines but up-regulated NANOG with less magnitude than lenvatinib did in S103. Overall, combined colchicine and 250 ng/mL lenvatinib had the best anti-cancer effects in S143, with similar effects with combined colchicine and 350 ng/mL lenvatinib in S176 but less effects than combined colchicine and 350 ng/mL lenvatinib in S103 and S160. Conclusions: Lenvatinib does not show a dose-dependent anti-cancer effect on HCC. Combined colchicine and lenvatinib can promote the total anti-cancer effects on HCC.
Impact of Postoperative Naples Prognostic Score to Predict Survival in Patients with Stage II–III Colorectal Cancer
Authors: Park Su Hyeong , Woo Hye Seung , Hong In Kyung , Park Eun Jung
Published: October 2023

Background: The Naples prognostic score (NPS) is a scoring system that reflects a patient’s systemic inflammatory and nutritional status. This study aimed to evaluate whether postoperative NPS is effective in assessing the prognosis of stage II–III colorectal cancer (CRC) patients compared with preoperative NPS. Methods: Between 2005 and 2012, a total of 164 patients diagnosed with stage II–III CRC, who underwent curative resection followed by adjuvant chemotherapy, were divided into two groups: Group 0–1 (NPS = 0–2) and Group 2 (NPS = 3 or 4). Preoperative NPS was calculated based on the results before surgeries, and postoperative NPS was assessed using the results obtained before adjuvant chemotherapy. Results: The overall survival of Group 0–1 was higher than that of Group 2 in both pre- and postoperative NPS assessments. According to the ROC curve analysis, the Area Under the Curve (AUC) ratio for postoperative NPS was 0.64, compared with 0.57 for preoperative NPS, 0.52 for the preoperative neutrophil–lymphocyte ratio (p = 0.032), and 0.51 for the preoperative platelet–lymphocyte ratio (p = 0.027). Conclusions: Postoperative NPS is effective in predicting the prognosis of stage II–III CRC patients who underwent curative resection followed by adjuvant chemotherapy. The use of NPS could be beneficial in evaluating the prognosis of CRC patients after surgeries.
Don’t Judge a Book by Its Cover: The Role of Statins in Liver Cancer
Authors: Piekuś-Słomka Natalia , Mocan Lavinia Patricia , Shkreli Rezarta , Grapă Cristiana , Denkiewicz Kinga , Wesolowska Oliwia , Kornek Miroslaw , Spârchez Zeno , Słomka Artur , Crăciun Rareș , Mocan Tudor
Published: October 2023

Statins, which are inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, are an effective pharmacological tool for lowering blood cholesterol levels. This property makes statins one of the most popular drugs used primarily to prevent cardiovascular diseases, where hyperlipidemia is a significant risk factor that increases mortality. Nevertheless, studies conducted mainly in the last decade have shown that statins might prevent and treat liver cancer, one of the leading causes of cancer-related mortality worldwide. This narrative review summarizes the scientific achievements to date regarding the role of statins in liver tumors. Molecular biology tools have revealed that cell growth and proliferation can be inhibited by statins, which further inhibit angiogenesis. Clinical studies, supported by meta-analysis, confirm that statins are highly effective in preventing and treating hepatocellular carcinoma and cholangiocarcinoma. However, this effect may depend on the statin’s type and dose, and more clinical trials are required to evaluate clinical effects. Moreover, their potential hepatotoxicity is a significant caveat for using statins in clinical practice. Nevertheless, this group of drugs, initially developed to prevent cardiovascular diseases, is now a key candidate in hepato-oncology patient management. The description of new drug-statin-like structures, e.g., with low toxicity to liver cells, may bring another clinically significant improvement to current cancer therapies.
The Applications and Pitfalls of Cone-Beam Computed Tomography-Based Synthetic Computed Tomography for Adaptive Evaluation in Pencil-Beam Scanning Proton Therapy
Authors: Tsai Pingfang , Tseng Yu-Lun , Shen Brian , Ackerman Christopher , Zhai Huifang A. , Yu Francis , Simone Charles B. , Choi J. Isabelle , Lee Nancy Y. , Kabarriti Rafi , Lazarev Stanislav , Johnson Casey L. , Liu Jiayi , Chen Chin-Cheng , Lin Haibo
Published: October 2023

Purpose: The study evaluates the efficacy of cone-beam computed tomography (CBCT)-based synthetic CTs (sCT) as a potential alternative to verification CT (vCT) for enhanced treatment monitoring and early adaptation in proton therapy. Methods: Seven common treatment sites were studied. Two sets of sCT per case were generated: direct-deformed (DD) sCT and image-correction (IC) sCT. The image qualities and dosimetric impact of the sCT were compared to the same-day vCT. Results: The sCT agreed with vCT in regions of homogeneous tissues such as the brain and breast; however, notable discrepancies were observed in the thorax and abdomen. The sCT outliers existed for DD sCT when there was an anatomy change and for IC sCT in low-density regions. The target coverage exhibited less than a 5% variance in most DD and IC sCT cases when compared to vCT. The Dmax of serial organ-at-risk (OAR) in sCT plans shows greater deviation from vCT than small-volume dose metrics (D0.1cc). The parallel OAR volumetric and mean doses remained consistent, with average deviations below 1.5%. Conclusion: The use of sCT enables precise treatment and prompt early adaptation for proton therapy. The quality assurance of sCT is mandatory in the early stage of clinical implementation.
Naringin–Dextrin Nanocomposite Abates Diethylnitrosamine/Acetylaminofluorene-Induced Lung Carcinogenesis by Modulating Oxidative Stress, Inflammation, Apoptosis, and Cell Proliferation
Authors: Mohamed Eman E. , Ahmed Osama M. , Zoheir Khairy M. A. , El-Shahawy Ahmed A. G. , Tamur Shadi , Shams Anwar , Burcher Jack T. , Bishayee Anupam , Abdel-Moneim Adel
Published: October 2023

Nanotechnology has proven advantageous in numerous scientific applications, one being to enhance the delivery of chemotherapeutic agents. This present study aims to evaluate the mechanisms underlying the chemopreventive action of naringin–dextrin nanocomposites (Nar-Dx-NCs) against diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced lung carcinogenesis in male Wistar rats. DEN was administered intraperitoneally (i.p.) (150 mg/kg/week) for two weeks, followed by the oral administration of 2AAF (20 mg/kg) four times a week for three weeks. Rats receiving DEN/2AAF were concurrently treated with naringin or Nar-Dx-NCs orally at a dose of 10 mg/kg every other day for 24 weeks. Naringin and Nar-Dx-NCs treatments prevented the formation of tumorigenic cells within the alveoli of rats exposed to DEN/2AAF. These findings were associated with a significant decrease in lipid peroxidation, upregulation of antioxidant enzyme (glutathione peroxidase and superoxide dismutase) activity, and enhanced glutathione and nuclear factor erythroid 2–related factor 2 expression in the lungs. Naringin and Nar-Dx-NCs exerted anti-inflammatory actions manifested by a decrease in lung protein expression of tumor necrosis factor-α and interleukin-1β and mRNA expression of interleukin-6, interferon-γ, nuclear factor-κB, and inducible nitric oxide synthase, with a concurrent increase in interleukin-10 expression. The anti-inflammatory effect of Nar-Dx-NCs was more potent than naringin. Regarding the effect on apoptosis, both naringin and Nar-Dx-NCs significantly reduced Bcl-2 and increased Bax and P53 expressions. Moreover, naringin or Nar-Dx-NCs induced a significant decrease in the expression of the proliferator marker, Ki-67, and the effect of Nar-Dx-NCs was more marked. In conclusion, Nar-Dx-NCs improved naringin’s preventive action against DEN/2AAF-induced lung cancer and exerted anticarcinogenic effects by suppressing oxidative stress and inflammation and improving apoptotic signal induction and propagation.
Achillea fragrantissima Essential Oil, Wild Grown in Saudi Arabia and Egypt: Detailed Comparative Chemical Profiling, and Evaluation of Allelopathic, Antioxidant, and Antibacterial Activities
Authors: Abd-ElGawad Ahmed M. , Ahmed Rania F. , Elshamy Abdelsamed I. , Sadek Eslam G. , Assaeed Abdulaziz M. , Bonanomi Giuliano , El Gendy Abd El-Nasser G. , El-Amier Yasser A.
Published: October 2023

One of the biologically beneficial oils against many ailments is Achillea fragrantissima essential oil (EO). The current study focused on the comprehensive comparative chemical characterization of A. fragrantissima EOs, which were gathered from Saudi Arabia and Egypt, as well as evaluation of their allelopathic, antioxidant, and antibacterial functions. With a respective total oil mass of 96.9% and 96.1%, 40 compounds were found in the EOs from Saudi Arabia (38 compounds) and Egypt (26 compounds). Terpenes represented the main constituents including mono- (52.6% and 75.4% from Saudi Arabia and Egypt, respectively) and sesquiterpenoids (42.1% and 19.7%, respectively). The α-thujone (12.0%), myrcenyl acetate (10.3%), alloaromadendrene oxide-(1) (5.9%), artemisia ketone (4.9%), β-thujone (4.7%), lavandulol (4.2%), and santolina alcohol (4.0%) represented the main components of the overall oil of the Saudi Arabian plant-derived EO. However, the main constituents of the EO of the Egyptian plant were 4-terpineol (17.4%), myrcenyl acetate (9.1%), artemisia ketone (9.0%), α-thujone (8.6%), yomogi alcohol (6.2%), santolina alcohol (6.2%), and β-thujone (5.8%). The chemometric analysis exhibited a strong association between the two EOs from Saudi Arabia and Egypt in addition to the samples collected from Jordan. The Saudi and Egyptian A. fragrantissima’ EOs were found to have significant allelopathic potencies against the weed C. murale. The seed germination, seedling shoot growth, and root growth of C. murale were all reduced by the EO of the Saudi ecospecies by 79.9, 56.7, and 68.6%, respectively, with IC50 values of 66.5, 68.0, and 69.2 µL L−1, respectively. The two oils from Saudi Arabia and Egypt exhibited potent antioxidant activity against the DPPH free radicals, with IC50 values of 30.94 and 28.72 mg/L, respectively. In addition, the two oils from Saudi Arabia and Egypt exhibited strong abilities to scavenge ABTS radicals with respective IC50 values of 39.02 and 37.13 mg/L. Additionally, the two EOs showed a much higher antibacterial activity than the antibiotics tested against all bacterial strains, with the exception of Enterobacter cloacae. The two oils exhibited antibacterial activity against the examined strains, except Bacillus subtilis and Salmonella typhimurium, for which the Egyptian species shown greater inhibition. The results revealed that Escherichia coli and Staphylococcus epidermidis were more sensitive, while Enterobacter cloacae was more resistant.
Contamination- and Perturbation-Free Fluorescent Monitoring of Zn2+ in Suspensions Using Crown Ether-Functionalized Magnetic Nanoparticles
Authors: Vezse Panna , Golcs Ádám , Tóth Tünde , Huszthy Péter
Published: October 2023

This study aims to introduce a fluorescence-based chemosensing method for Zn2+ in aqueous suspensions and untreated surface waters, conditions which generally hinder the application of conventional optochemical sensing platforms. A macrocyclic fluoroionophore was covalently bonded to a silica-coated magnetic nanoparticle and applied according to a predetermined protocol for analyzing trace amounts of Zn2+ under rarely investigated conditions. Utilizing the reversible complexation of the immobilized fluoroionophore, rapid regeneration was carried out via simple acidification after the magnetic-assisted solid-phase extraction of the particles. Forming inclusion complexes with Zn2+ with the receptor units of the particles leads to a significant enhancement in fluorescence intensity at 370 nm, above the detection limit of 5 ppb, with a dynamic linear range of quantification of 15–3000 ppb in a pH range of 5.5–7.5. Practical applicability was confirmed by analyzing untreated river water and an aqueous suspension of pumpkin seed flour as real and relevant heterogeneous multicomponent samples of predetermined sample composition and natural Zn2+ content. Our practical approach aims to broaden the applicability range of optochemical sensing platforms for Zn2+.
A Cross-Sectional Analysis of Dietary Patterns in Healthy Adolescents: Energy Balance, Nutrient Intake, Body Mass, and Serum Marker Alterations
Authors: Martin Ștefan Adrian , Martin-Hadmaș Roxana Maria
Published: October 2023

(1) Background: With shifts in daily dietary habits, concerns have arisen regarding potential impacts on metabolic health. This study sought to investigate the interplay between nutrient intake and its effects on the anthropometric and inflammatory profiles of young individuals. (2) Methods: Our approach examined the interrelation of caloric, macronutrient, and vitamin intakes with inflammatory markers, serum cholesterol, triglycerides, and other key metrics. The impact of these factors on body mass and inflammation was evaluated. (3) Results: This study found that while increased caloric intake corresponded to a rise in body fat mass, it did not significantly alter body weight, total protein, or fat profile. A dominant carbohydrate intake negatively correlated with vitamin B consumption. Interestingly, only vitamin K showcased a direct association with IL-6, while IL-8 remained unassociated with dietary intake and body mass metrics. (4) Conclusions: Dietary intake undeniably influences nutrient consumption and subsequently affects body mass metrics. Though an escalation in body fat mass was evident with increased food intake, the relationship between vitamins and inflammatory markers, based on macronutrient and caloric intake, remains inconclusive. The findings point to the potential regulatory roles of proteins and select vitamins in inflammation, emphasizing the need for deeper longitudinal studies to further validate these connections.
Cutaneous, Cranial, and Skeletal Defects in Children and Adults with Focal Dermal Hypoplasia
Authors: Al Kaissi Ali , Ryabykh Sergey , Kenis Vladimir , Ben Chehida Farid , Al Kaissi Hamza , Kircher Susanne Gerit , Grill Franz
Published: October 2023

Background: The diagnostic process for children and adults manifesting a constellation of ectodermal abnormalities requires a conscientious and highly structured process. Material and Methods: Six girls (aged 6-month–8 years) and two older girls (aged 13 and 16 years) were born with variable skin lesions of varying intensities associated with noticeable cranial and skeletal malformation complexes. Cleft palate, abnormal dentition, and multiple papillomas were evident around the mouth, mostly bilateral but asymmetrical in the upper and lower limbs. Exaggerated frontal bossing (macrocephaly) and in some patients’ microcephaly with variable skeletal defects of the craniocervical junction and diverse forms of lower limb deformities of syndactyly, polydactyly, and split-hand/foot (ectrodactyly). Results: All patients manifested the constellation of abnormalities with variable intensities ranging between alopecia, papillomas, striated skin pigmentations split-hand/foot (ectrodactyly), and major bone defects. A 3D reconstruction CT scan was directed mainly to further scrutinize children with pseudo cleft lip, submucus cleft, and cleft palate. Interstingly, they manifested massive demineralization of the cranium associated with severely defective dentition. A spine 3D reconstruction CT scan in two girls showed marked cystic cavitation of the upper jaw associated with excessive cavitation of the mastoid, causing tremendous frailty of the mastoid bone. A 3D sagittal CT scan showed odontoid hypoplasia and C1-2 instability associated with the rudimentary atlas and the persistence of extensive synchondrosis of the cervico-thoracic spine. The overall clinical and radiological phenotypic characterizations were consistent with the diagnosis of focal dermal hypoplasia (Goltz syndrome). Two children manifested heterozygous mutations in the PORCN gene, chromosome Xp11. Conclusions: In this study, we believe it’s a good opportunity to share our novel scientific findings, which are intriguing and can be inspiring to readers, and to further aid the current scientific literature with exceptionally new unveiling results. This is the first comprehensive study of the cranio-skeletal malformation complex in children with GS.
Study of Gas Swelling Processes under Irradiation with Protons and He2+ Ions in Li4SiO4–Li2TiO3 Ceramics
Authors: Kenzhina Inesh E. , Kozlovskiy Artem L. , Chikhray Yevgen , Kulsartov Timur , Zaurbekova Zhanna , Begentayev Meiram , Askerbekov Saulet
Published: October 2023

One of the important areas of research in the energy sector is the study of the prospects for using new types of nuclear fuel, including tritium, which is one of the most promising types of fuel for thermonuclear energy. At the same time, for the production of tritium in the required quantities, the one that is the most optimal is the use of blanket materials based on lithium-containing ceramics. This is where tritium is released from lithium under the influence of neutron irradiation. The paper presents the results of an investigation of the influence of two-phase ceramics based on Li4SiO4–Li2TiO3 compounds on the resistance to external influences (mechanical loads) during the accumulation of hydrogen and helium (He2+) in the near-surface layer. The interest in such studies is primarily related to the search for solutions in the field of creating high-strength materials for tritium generation for its further use as nuclear fuel for thermonuclear fusion, as well as to the study of the mechanisms of the influence of different phases on the changes in the strength properties of ceramics, which provides an opportunity to expand fundamental knowledge in this area. The proposed method of obtaining two-phase ceramics by mechanical-chemical mixing and subsequent sintering into spherical particles enables the production of well-structured, high-strength ceramics of specified geometric dimensions (limited only by the dimensions of the mold) with a controlled phase ratio. During the experiments, it was found that increasing the content of Li4SiO4 phase in ceramics leads to an increase in strength characteristics (hardness, resistance to cracking) by 15–20% compared to single-phase ceramics. The most optimal composition of two-phase ceramics with high resistance to destructive embrittlement is the ratio of phases 0.75Li4SiO4–0.25Li2TiO3. One of the factors explaining the increase in resistance to destructive embrittlement under high-dose irradiation for two-phase ceramics is the increased dislocation density and the presence of interphase or intergranular boundaries, the high concentration of which leads to the creation of additional obstacles to the agglomeration of hydrogen and helium in the near-surface layer.
The Magnetic Properties and Photoactivity of Bi-Magnetic Nanostructures for Hydrogen Production
Authors: Alsnani Hind , Khowdiary Manal M. , Darwish Mohamed S. A.
Published: October 2023

The major challenge of hydrogen production via photocatalytic water-splitting is to utilize active photocatalysts that respond to a wide range of visible light. In this work, hybrid nanostructures purposed to combine the tunable magnetic behavior of soft/semi-hard magnetic particles have shown advantageous photoactivity. A series of photocatalysts based on ferrite nanoparticles, magnetite nanoparticles (MNPs), cobalt ferrite nanoparticles (CFNPs), magnetite nanoparticles coated on cobalt ferrite nanoparticles (MNPs @ CFNPs), and cobalt ferrite nanoparticles coated on magnetite nanoparticles (CFNPs @ MNPs) were prepared. The size, morphology, magnetic properties, and optical activity of the prepared nanoparticles were characterized using multiple techniques. CFNPs @ MNPs had the largest particle size (~14 nm), while CFNPs had the smallest (~8 nm). The saturation magnetization of CFNPs @ MNPs was the highest at 55.45 emu g−1. The hydrogen yield was 60, 26, 3.8, and 93 mmole min−1 g−1 for MNPs, CFNPs, MNPs @ CFNPs, and CFNPs @ MNPs. CFNPs @ MNPs displayed a superior photocatalytic performance for hydrogen production under the magnetic force as appropriate materials for water-splitting processing.
Enhanced Recovery after Surgery (ERAS) for Minimally Invasive Gynecologic Oncology Surgery: A Review
Authors: Aubrey Christa , Nelson Gregg
Published: October 2023

Enhanced recovery after surgery (ERAS) has established benefits in open gynecologic oncology surgery. However, the benefits for gynecologic oncology patients undergoing minimally invasive surgery (MIS) are less well defined. We conducted a review of this topic after a comprehensive search of the peer-reviewed literature using MEDLINE and PubMed databases. Our search yielded 25 articles, 14 of which were original research articles, in 10 distinct patient cohorts describing ERAS in minimally invasive gynecologic oncology surgery. Major benefits of ERAS in MIS included: decreased length of stay and increased rates of same-day discharge, cost-savings, decreased opioid use, and increased patient satisfaction. ERAS in minimally invasive gynecologic oncology surgery is an area of great promise for both patients and the healthcare system.
Specialty Care and Counselling about Hereditary Cancer Risk Improves Adherence to Cancer Screening and Prevention in Newfoundland and Labrador Patients with BRCA1/2 Pathogenic Variants: A Population-Based Retrospective Cohort Study
Authors: Roebothan Aimee , Smith Kerri N. , Seal Melanie , Etchegary Holly , Dawson Lesa
Published: October 2023

Pathogenic variants (PVs) in BRCA1 and BRCA2 increase the lifetime risks of breast and ovarian cancer. Guidelines recommend breast screening (magnetic resonance imaging (MRI) and mammogram) or risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO). We sought to (1) characterize the population of BRCA1/2 PV carriers in Newfoundland and Labrador (NL), (2) evaluate risk-reducing interventions, and (3) identify factors influencing screening and prevention adherence. We conducted a retrospective study from a population-based provincial cohort of BRCA1/2 PV carriers. The eligibility criteria for risk-reducing interventions were defined for each case and patients were categorized based on their level of adherence with recommendations. Chi-squared and regression analyses were used to determine which factors influenced uptake and level of adherence. A total of 276 BRCA1/2 PV carriers were identified; 156 living NL biological females composed the study population. Unaffected females were younger at testing than those with a cancer diagnosis (44.4 years versus 51.7 years; p = 0.002). Categorized by eligibility, 61.0%, 61.6%, 39.0%, and 75.7% of patients underwent MRI, mammogram, RRM, and RRSO, respectively. Individuals with breast cancer were more likely to have RRM (64.7% versus 35.3%; p < 0.001), and those who attended a specialty hereditary cancer clinic were more likely to be adherent to recommendations (73.2% versus 13.4%; p < 0.001) and to undergo RRSO (84.1% versus 15.9%; p < 0.001). Nearly 40% of the female BRCA1/2 PV carriers were not receiving breast surveillance according to evidence-based recommendations. Cancer risk reduction and uptake of breast imaging and prophylactic surgeries are significantly higher in patients who receive dedicated specialty care. Organized hereditary cancer prevention programs will be a valuable component of Canadian healthcare systems and have the potential to reduce the burden of disease countrywide.
Seasonal Variations in Invertebrates Sheltered among Corallina officinalis (Plantae, Rodophyta) Turfs along the Southern Istrian Coast (Croatia, Adriatic Sea)
Authors: Buršić Moira , Jaklin Andrej , Arko Pijevac Milvana , Bruvo Mađarić Branka , Neal Lucija , Pustijanac Emina , Burić Petra , Iveša Neven , Paliaga Paolo , Iveša Ljiljana
Published: October 2023

Available research on invertebrates in Corallina officinalis settlements shows a high level of biodiversity due to a complex habitat structure. Our aim was to examine seasonal changes in the invertebrate population, considering the algae’s growth patterns. Nine locations with over 90% algal coverage were selected in southern Istria, where quantitative sampling was performed using six replicates of 5 × 5 cm quadrats in each location. Results showed that 29,711 invertebrates were found during winter (maximum algae growth) and 22,292 during summer (minimum algae growth), with an extrapolated average density of 220,000 and 165,200 individuals per square meter, respectively. The total number of individuals showed a linear increase as the algae biomass increased. The highest density, 586,000 individuals, was recorded in the Premantura area during winter. Dominant groups such as amphipods, polychaetes, bivalves and gastropods made up over 80% of the invertebrates. Our study confirms high invertebrate richness in the C. officinalis settlements, with the maximum density being the highest when compared to previously published data.
Species Diversity and Soil Interconstraints Exert Significant Influences on Plant Survival during Ecological Restoration in Semi-Arid Mining Areas
Authors: Shi Zeyu , Bai Zhongke , Guo Donggang , Li Shuai , Chen Meijing
Published: October 2023

The extensive vegetation destruction in opencast mining regions has led to various environmental problems, including the loss of biodiversity. However, our understanding of biodiversity’s response to survival, as well as its interactions with soil characteristics and climate change, remains limited. To address this gap, we analyzed data from a long-term monitoring site in an opencast coal mine reclamation region, focusing on the effects of species diversity, soil properties, and climate factors on the survival of four key restored species at 17, 22, and 27 years after planting. Our findings indicate that increased plot diversity is associated with decreased overall survival, and significant variations in diversity levels were observed among different plots. We also found that soil properties influenced species’ survival response to diversity, and these responses varied with stand age. In the early stages of succession, soil and diversity primarily affect species survival, with diversity playing a more dominant role as stand age increases. Overall, our findings suggest that the interaction between species diversity and soil composition significantly influences the survival of species. Continuous monitoring is necessary to validate these conclusions, particularly considering the diverse planting patterns in mine reclamation areas that can result in varying feedbacks of biodiversity on species survival.
Effect of Interference Size on Contact Pressure Distribution of Railway Wheel Axle Press Fitting
Authors: Irena Kitesa Akewaq , Lemu Hirpa G. , Kedir Yahiya Ahmed
Published: October 2023

Mechanical couplings in engineering usually use interference fits to connect the shaft and hub. A railway wheel axle is a press fit that is connected by interference and can be subjected to bending stress. In loaded press fits, a high concentration of contact stresses can be generated in the area of the axle-fillet beam, which in most cases leads to the failure of the axle due to fatigue and fretting fatigues. Therefore, it is crucial to determine the ability of the press-fitted joints to provide sufficient frictional resistance that can withstand the loads and torques by evaluating the safety factor, especially when the mechanical or structural system is loaded. In this paper, the contact pressure and stress distribution along the radius of the wheel axle are studied using the analytical calculation of Lame’s equation, and the numerical method used is by ANSYS software. It was found that interference fits have a great influence on the connection strength of interference fits, which are directly related to the contact pressure. Increasing the interference increases the contact pressure, which allows higher torque and load capacity to be transmitted. The finite element analysis showed good agreement for the highest interference value of 230 µm with a relative error of 1.4%, while this error increased to the maximum relative error of 14.33% for a minimum interference of 100 µm.
Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid
Authors: Elghobashy Maiar , Gama Rousseau , Sulaiman Raashda Ainuddin
Published: October 2023

Although adult spontaneous (non-diabetic) hypoglycaemia is rare, its recognition is important for the preventative or curative treatment of the underlying cause. Establishing Whipple’s triad—low blood glucose, neuroglycopaenia and resolution of neuroglycopaenia on increasing blood glucose levels to normal or above—is essential to verify hypoglycaemia. Awareness that hypoglycaemia may occur in severely ill patients is important for its prevention. Further investigation in such cases is unnecessary unless another cause of hypoglycaemia is suspected. Patients are often asymptomatic and normoglycaemic at review. Their history of medication, self-medication, access to hypoglycaemic drugs, alcohol use and comorbidity may provide aetiological clues. The investigation involves obtaining blood samples during symptoms for laboratory glucose measurement or provoking fasting or postprandial hypoglycaemia as directed by symptoms. If confirmed, insulin, c-peptide, proinsulin and beta-hydroxybutyrate are analysed in hypoglycaemic samples. These will classify hypoglycaemia due to non-ketotic hyperinsulinaemia, non-ketotic hypoinsulinaemia and ketotic hypoinsulinaemia, and direct investigations to identify the underlying cause. There are, however, many pitfalls that may mislabel healthy individuals as “hypoglycaemic” or misdiagnose treatable or preventable causes of spontaneous hypoglycaemia. Clinical acumen and appropriate investigations will mostly identify hypoglycaemia and its cause.
Brochoscopic Airway Clearance Therapy vs. Conventional Sputum Aspiration: The Future of Flexible Brochoscopes in Intensive Care Units?
Authors: Yao Anjie , Liu Zixuan , He Wenni , Rao Hanyu , Wang Changhui , Xie Shuanshuan
Published: October 2023

(1) Background: The aim of our study is to investigate the effectiveness of bronchoscopic airway clearance therapy (B-ACT) on severe pneumonia (SP) patients with invasive mechanical ventilation (IMV) in the intensive care unit (ICU). (2) Methods: Our study retrospectively enrolled 49 patients with sputum aspiration and 99 patients with B-ACT, and the latter were divided into the ≤once every 3 days group (n = 50) and >once every 3 days group (n = 49). (3) Results: We found most laboratory blood results were significantly improved in the B-ACT group as compared with those in sputum aspiration group (p < 0.05). Patients in the B-ACT group and those in ≤once every 3 days group also had significantly better survival to hospital discharge than those in their counterpart groups (Logrank p < 0.001). In patients with cardiopulmonary diseases or positive cultures for bacteria, the B-ACT group and those in the ≤once every 3 days group had significantly better survival outcomes to discharge than those in their counterpart groups (Logrank p < 0.001). B-ACT and the average frequency of ≤once every 3 days had significantly better impact on survival outcomes than their counterpart groups (HR: 0.444, 95% CI: 0.238–0.829, p = 0.011; HR: 0.285, 95% CI: 0163–0.498, p < 0.001). (4) Conclusions: In the future, flexible bronchoscopes may paly an important role in ACT for SP patients with IMV.
New Construction of Asynchronous Channel Hopping Sequences in Cognitive Radio Networks
Authors: Wang Yaoxuan , Niu Xianhua , Qi Chao , He Zhihang , Zeng Bosen
Published: October 2023

The channel-hopping-based rendezvous is essential to alleviate the problem of under-utilization and scarcity of the spectrum in cognitive radio networks. It dynamically allows unlicensed secondary users to schedule rendezvous channels using the assigned hopping sequence to guarantee the self-organization property in a limited time. In this paper, we use the interleaving technique to cleverly construct a set of asynchronous channel-hopping sequences consisting of d sequences of period xN2 with flexible parameters, which can generate sequences of different lengths. By this advantage, the new designed CHSs can be used to adapt to the demands of various communication scenarios. Furthermore, we focus on the improved maximum-time-to-rendezvous and maximum-first-time-to-rendezvous performance of the new construction compared to the prior research at the same sequence length. The new channel-hopping sequences ensure that rendezvous occurs between any two sequences and the rendezvous times are random and unpredictable when using licensed channels under asynchronous access, although the full degree-of-rendezvous is not satisfied. Our simulation results show that the new construction is more balanced and unpredictable between the maximum-time-to-rendezvous and the mean and variance of time-to-rendezvous.
Gaussian and Lerch Models for Unimodal Time Series Forcasting
Authors: Dermoune Azzouz , Ounaissi Daoud , Slaoui Yousri
Published: October 2023

We consider unimodal time series forecasting. We propose Gaussian and Lerch models for this forecasting problem. The Gaussian model depends on three parameters and the Lerch model depends on four parameters. We estimate the unknown parameters by minimizing the sum of the absolute values of the residuals. We solve these minimizations with and without a weighted median and we compare both approaches. As a numerical application, we consider the daily infections of COVID-19 in China using the Gaussian and Lerch models. We derive a confident interval for the daily infections from each local minima.
Concrete–Representational–Abstract (CRA) Instructional Approach in an Algebra I Inclusion Class: Knowledge Retention Versus Students’ Perception
Authors: Prosser Sherri K. , Bismarck Stephen F.
Published: October 2023

Mathematical manipulatives and the concrete–representational–abstract (CRA) instructional approach are common in elementary classrooms, but their use declines significantly by high school. This paper describes a mixed methods study focused on knowledge retention and perceptions of students in a high school Algebra I inclusion class after a lesson on square roots using a novel algebra manipulative. Twenty-five students in a high school Algebra I inclusion class engaged in an interactive lesson on square roots paired with the manipulative to support their conceptual understanding. Participants completed a pretest, a post-treatment questionnaire, and a delayed post-test. The two-sample t test showed a significant difference in students’ pretest–post-test scores. However, conventional content analysis of the questionnaires showed that most students did not believe the CRA instructional approach supported their learning. Implications include increased use of manipulatives to teach abstract algebraic topics to support students’ conceptual understanding and destigmatizing the use of manipulatives in secondary mathematics classrooms.