bluuebunny/crossref_metadata_2025 huggingface dataset:
A Newly Developed Immunoisolated Bioartificial Pancreas with Cell Sheet Engineering
Authors: Lee Jeong Ik , Nishimura Ryohei , Sakai Hideaki , Sasaki Nobuo , Kenmochi Takashi
Published: April 2008

The term “immunoisolation” refers to the encapsulation of a graft in a selectively permeable membrane. Encapsulation of cellular grafts may provide a way to protect the graft from immune attack without the need for immunosuppressive agents. Although numerous types of artificial materials have been used for encapsulating membranes, their incomplete biocompatibility causes foreign body reaction against the membranes. A new technique has been developed, called cell sheet engineering using temperature-responsive culture dishes, that allows the use of living cells as an immunoisolating membrane in this study. Using this method, the cultured cells can be easily harvested in the shape of a sheet by a simple change of the temperature without the use of proteolytic enzymes. A cell sheet can be created with three-dimensional structure by making multiple cell sheet layers. In this study, a new technique of macroencapsulation (bioartificial organs) has been developed using chondrocyte sheets. Among the various candidate cells, pancreatic islet cells were selected for a bioartificial organ in this study. A chondrocyte sheeting immunodelusive immunoisolated bioartificial pancreas (CSI-BAP) was manufactured by means of cell sheet engineering. An auricular cartilage, which is a histologically elastic cartilage from dogs (beagle), was used as a source of immunoisolating membrane. CSI-BAP was made by multilayering the chondrocyte sheets, and the donor's islets were located between each sheet. Islets were isolated and prepared from the dog (ALLO-model) and Brown Norway (BN) rat (XENO-model). The CSI-BAP was cultured for 83 days and the cultured medium was collected every 24 h to measure the insulin concentrations. The CSI-BAP was examined histologically using hematoxyhin and eosin (H&E), and azan dye staining. In addition, immunohistochemical staining was performed to demonstrate the insulin production of CSI-BAP. Insulin secretion of CSI-BAP on day 16 was reduced to 21.4% of the insulin secretion level of day 10, which was the start point of measurement. Although a gradual reduction was observed, insulin secretion was maintained for 3 months. The CSI-BAP was capable of secreting insulin to the culture medium during the observation period. Histological evaluations demonstrated the good viability of the islets, and immunohistochemistry showed the positive staining of insulin. This novel technology may be used for other kinds of endocrine cells or hepatocytes, which may become the models for immunoisolated bioartificial organs in the near future.
Carbamylated Erythropoietin Improves Angiogenesis and Protects the Kidneys from Ischemia-Reperfusion Injury
Authors: Imamura Ryoichi , Okumi Masayoshi , Isaka Yoshitaka , Ichimaru Naotsugu , Moriyama Toshiki , Imai Enyu , Nonomura Norio , Takahara Shiro , Okuyama Akihiko
Published: April 2008

Several studies have shown that erythropoietin (EPO) can protect the kidneys from ischemia-reperfusion injury and can raise the hemoglobin (Hb) concentration. Recently, the EPO molecule modified by carbamylation (CEPO) has been identified and was demonstrated to be able to protect several organs without increasing the Hb concentration. We hypothesized that treatment with CEPO would protect the kidneys, partly due to the increased peritubular capillaries. The therapeutic effect of CEPO was evaluated using an endothelial tube formation assay in vitro, and a rat ischemia-reperfusion injury model in vivo. EPO treatment showed the tendency of increased tube formation, while CEPO treatment induced more capillary-like formation than EPO. Ischemia-reperfusion-induced kidneys exhibited characteristic nuclei of apoptosis in tubular epithelial cells with decreased peritubular capillaries, while EPO treatment inhibited tubular apoptosis with preserved endothelial cells. Moreover, CEPO-treated kidneys showed minimal tubular apoptosis with increased peritubular capillary endothelial cells. In conclusion, we identified a new therapeutic approach using CEPO to protect kidneys from ischemia-reperfusion injury by promoting angiogenesis.
Artificial Cells for the Development of Cell Therapy
Authors: Kobayashi Naoya
Published: April 2008

In developing cell therapy, normal human cells are ideal as a cell source, but considering the serious lack of donor organs, it is unlikely to obtain a large enough amount of human cells. Moreover, even with current culturing techniques, the long-term culturing of normal human cells is difficult. On the other hand, in using xenogenic porcine cells and human tumor tissue-derived cell lines, there is concern that species-specific pathogens can be transmitted (such as infection by porcine endogenous retroviruses), and possible cancer may thus develop in recipients. Therefore, we are making efforts toward establishing reversible immortalized human cell lines that can be economically grown in tissue culture using the techniques of gene transfer in order to solve these problems. I here describe a strategy for establishing human reversibly immortalized cell lines that are intended for practical application in cell therapies. I would like to further contribute toward the realization of tissue engineering in fusional coordination with cell-processing technology by the utilization of such cell line constructing techniques.
Bioartificial Pancreas for the Treatment of Diabetes
Authors: Kobayashi Naoya
Published: April 2008

Recent advances in islet transplantation using highly purified islets and effective immunosuppression strategies have resulted in substantial improvement in achieving insulin independence in type 1 diabetes patients. However, there are side effects from long-term immunosuppression, and transplant rejection and/or the recurrence of autoimmune attack of the transplanted islets cannot be completely prevented, even with immunosuppressive treatment. Therefore, construction of a safe and functional bioartificial pancreas (BAP) that provides an adequate environment for islet cells may be an important approach to treat diabetic patients. Various types of BAP devices have been developed and examined in animals. In this review, I introduce the previous BAP studies and our approach of BAP development.
Glycocalyx Damage Estimated Using Colloidal Iron Staining
Authors: Zhang Daoxin , Isaka Yoshitaka , Imamura Ryoichi , Ichimaru Naotsugu , Shi Yi , Imai Enyu , Tian Ye , Ohtsuka Aiji , Takahara Shiro
Published: April 2008

Anionic constituents in the peritubular capillary basement membranes and the glomerular endothelial cells have been demonstrated to function as a size- and charge-selective barrier. Cationic colloidal iron staining of human biopsy specimens revealed a glycocalyx on the surface of the glomerular basement membrane (GBM), peritubular capillary (PTC) endothelial cells, and brush border of the tubular epithelial cells of normal kidney. However, the glycocalyx was abolished in the PTC wall of C4d-positive acute humoral rejected kidney, and in the GBM as well as the PTC wall of a chronic, allograft, nephropathy kidney. In addition, cyclosporine eliminated the glycocalyx in the PTC wall, while treatment with heparin inhibited the elimination of the PTC glycocalyx. In conclusion, the glycocalyx on the surface of the GBM and PTC is an important component in the endothelial cell barrier.
Influence of proficiency level and constraints on viewpoint switching: a study in web design
Authors: Chevalier Aline , Chevalier Nicolas
Published: April 2008

Web design is a complex problem in which designers have to consider the user's and the client's viewpoints to make satisfactory websites. Designers, particularly proficient ones, tend to privilege to the client's viewpoint to the detriment of the users' one. Consequently, websites often contain many usability violations and do not fit users' cognitive capacities, hence hampering navigation. The usability quality of websites may be proportional to designers' ability to switch between the client's and the user's viewpoints, which in turn may be influenced by designers' proficiency level. To explore the role of viewpoint switching in web design, performance was compared across three conditions emphasizing either the client's viewpoint, that of the user, or none of them in order to promote or hamper viewpoint switching. This manipulation had a significant effect on proficient designers' performance. Moreover, a significant relation between viewpoint switching and the usability quality of e‐mock‐ups was found. Copyright © 2008 John Wiley & Sons, Ltd.
Two new cases of pure 1q terminal deletion presenting with brain malformations
Authors: Hiraki Yoko , Okamoto Nobuhiko , Ida Tomoko , Nakata Yusei , Kamada Masahiro , Kanemura Yonehiro , Yamasaki Mami , Fujita Hiroko , Nishimura Gen , Kato Mitsuhiro , Harada Naoki , Matsumoto Naomichi
Published: April 2008

We describe two new cases of pure 1q terminal deletions. BAC FISH analysis precisely defined the size of deletions. The first is a girl with 10.3‐Mb deletion showed typical features of 1q43 deletion as well as a simplified gyral pattern, which was rarely found in 1q43 deletion. The other boy also presented with most of 1q43 deletion features but several atypical symptoms were noted including hydrocephalus, adducted thumbs, and flexion restriction of proximal interphalangeal joints in left hand. A concomitant novel missense mutation in L1CAM was identified in addition to 11.5‐Mb deletion. Reviewing all the cases of pure 1q terminal deletion in the literature suggests that it is a clinically recognizable syndrome. © 2008 Wiley‐Liss, Inc.
Twin study refining psychotic symptom dimensions as phenotypes for genetic research
Authors: Cardno Alastair G. , Rijsdijk Frühling V. , Murray Robin M. , McGuffin Peter
Published: April 2008

We investigated which psychotic symptom dimensions are likely to be most useful as phenotypes for genetic linkage and association studies. Two hundred twenty‐four probandwise twin pairs (106 monozygotic,118 same‐sex dizygotic), where probands had psychosis, were ascertained from the Maudsley Twin Register in London. Dimensions were defined as ordinal symptom scores using the OPCRIT checklist, based on previous factor analyses of this and other samples. To qualify as a potentially useful phenotype, dimensions had to show (a) a satisfactory polychoric model fit and significant within‐pair correlation in MZ pairs concordant for DSM‐III‐R psychosis and (b) that they could not be better defined in terms of other combinations of relevant symptoms, single symptoms, or dichotomized dimension scores. Relationships between dimension scores in twin probands and risk of psychosis in co‐twins were also investigated. None of the positive or negative dimensions satisfied the phenotypic criteria. The disorganized dimensions showed significant and substantial correlations which maximized for a narrow definition. Combined negative/disorganized dimensions also showed significant and substantial correlations, but did not have advantages over disorganized dimensions. None of the dimensions were significant predictors of psychosis risk in co‐twins. We conclude that, of the dimensions analyzed, the narrow disorganized dimension shows most promise as a phenotype for molecular genetic research. © 2008 Wiley‐Liss, Inc.
Activated Src kinases interact with the N‐methyl‐D‐aspartate receptor after neonatal brain ischemia
Authors: Jiang Xiangning , Mu Dezhi , Biran Valerie , Faustino Joel , Chang Shengjun , Rincón Christina M. , Sheldon R. Ann , Ferriero Donna M.
Published: April 2008

Objective

Neonatal stroke is associated with the N‐methyl‐D‐aspartate receptor (NMDAR)–mediated excitotoxic brain injury. Src family kinases (SFKs) are considered to be the molecular hub for NMDAR regulation. We determined the relationship between SFKs activation and NMDAR tyrosine phosphorylation after neonatal hypoxia‐ischemia (HI) and investigated the neuroprotective potential of a selective SFKs inhibitor, PP2 (4‐amino‐5‐(4‐chlorophenyl)‐7‐(t‐butyl) pyrazolo [3, 4‐d] pyramidine), against neonatal brain ischemic injury.

Methods

The Rice–Vannucci model was adapted for neonatal HI injury in postnatal day 7 CD1 mice. SFKs activity in the postsynaptic densities was measured by Western blot. NMDAR tyrosine phosphorylation and their association with SFKs were determined by coimmunoprecipitation. Brains from animals treated with PP2 or its inactive analog, PP3, were examined histologically with cresyl violet and iron stain to assess the degree of damage.

Results

Neonatal HI resulted in a rapid and transient increase in tyrosine phosphorylation of NMDAR subunits NR2A and NR2B. This upregulation correlated with the enhanced association of Fyn and Src with NR2A and NR2B. SFKs were activated in the postsynaptic densities after HI. Inhibition of SFKs with PP2 attenuated brain injury after neonatal HI, whereas PP3 did not protect the brain from the HI insult.

Interpretation

SFKs may play an important role in NMDAR‐mediated excitotoxicity and downstream events leading to neuronal death after neonatal HI. Inhibition of SFKs may provide protection against neonatal stroke. Rather than blockade of NMDAR after HI in the developing brain, it may be safer and more beneficial to manipulate components of the NMDAR signaling complex at the postsynaptic density. Ann Neurol 2008
Neonate hippocampal volumes: Prematurity, perinatal predictors, and 2‐year outcome
Authors: Thompson Deanne K. , Wood Stephen J. , Doyle Lex W. , Warfield Simon K. , Lodygensky Gregory A. , Anderson Peter J. , Egan Gary F. , Inder Terrie E.
Published: April 2008

Objective

To compare preterm (PT) and full‐term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome.

Methods

A total of 184 PT and 32 full‐term infants underwent magnetic resonance imaging at term equivalent age with manual segmentation of the hippocampi on coronal slices. Perinatal data were collected and 2‐year neurodevelopment was evaluated with the Mental Development Index and Psychomotor Development Index on the Bayley Scales of Infant Development.

Results

PT and FT infant hippocampi did not significantly differ after controlling for head size, and percentage reductions in PT hippocampi (3.4%) were less than for cortical (7%) and deep nuclear gray matter (13%), and total brain tissue volume (4.7%). PT hippocampal volumes were significantly lower in infants with moderate‐to‐severe white matter injury (p < 0.001), exposure to postnatal steroids (right, p = 0.001; left, p = 0.008), and indomethacin treatment (right, p = 0.01; left, p = 0.03). PT infant hippocampal volumes correlated with the Mental (p < 0.001) and Psychomotor Development Indices (right, p = 0.001; left, p = 0.002) after correcting for head size and sex, but remained significant only for the Mental Development Index and left hippocampi (p = 0.04) after additionally adjusting for white matter injury and steroids.

Interpretation

Hippocampal volumes were reduced in PT infants exposed to several perinatal events but were preserved in PT infants without these exposures. Smaller PT hippocampal volumes were indirectly associated with delayed development at 2 years. Ann Neurol 2008
Anti‐MuSK patient antibodies disrupt the mouse neuromuscular junction
Authors: Cole Rebecca N. , Reddel Stephen W. , Gervásio Othon L. , Phillips William D.
Published: April 2008

Objective

A subset of myasthenia gravis patients that are seronegative for anti‐acetylcholine receptor (anti‐AChR) antibodies are instead seropositive for antibodies against the muscle‐specific kinase (anti‐MuSK–positive). Here, we test whether transfer of IgG from anti‐MuSK–positive patients to mice confers impairment of the neuromuscular junction and muscle weakness.

Methods

IgG from anti‐MuSK–positive myasthenia gravis patients or control IgG (seronegative for AChR and MuSK) was injected intraperitoneally (45mg daily for 14 days) into 6‐week‐old female FVB/NJ and C57BL/6J mice. Changes at neuromuscular junctions in the tibialis anterior and diaphragm muscles were assessed by confocal fluorescent imaging of AChRs stained with fluorescent‐α‐bungarotoxin. Loss of function was assessed by electromyography.

Results

In experimental mice injected with anti‐MuSK–positive patient IgG, postsynaptic AChR staining was reduced to as little as 22% of that seen in control mice. Experimental mice showed reduced apposition of the nerve terminal (labeled with antibodies against synaptophysin and neurofilament) and the postsynaptic AChR cluster (labeled with fluorescent‐α‐bungarotoxin). Mice injected with IgG from two of three anti‐MuSK–positive patients lost weight and developed muscle weakness associated with a decremental electromyographic trace on repetitive nerve stimulation.

Interpretation

IgG from anti‐MuSK–positive patients can cause myasthenia gravis when injected into mice. This may be explained by a progressive reduction in the density of postsynaptic AChR combined with changes in the nerve terminal and its relation to the postsynaptic structure. Ann Neurol 2008
Ethylene polymerization by (α‐diimine)nickel(II) complexes bearing different substituents on para‐position of imines activated with MMAO
Authors: Liu Jingyu , Li Yanguo , Li Yuesheng , Hu Ninghai
Published: April 2008

A series of (α‐diimine)nickel(II) complexes [ArN = C(Nap)C = NAr]NiBr2 (Nap = 1,8‐naphthdiyl, Ar = 2,6‐Me2C6H3, 3a; Ar = 2,4,6‐Me3C6H23b; Ar = 2,6‐Me2‐4‐tBuC6H2, 3c; Ar = 2,6‐Me2‐4‐BrC6H2, 3d; Ar = 2,6‐Me2‐4‐ClC6H2, 3e; Ar = 2,6‐iPr2C6H3, 3f; Ar = 2,4,6‐iPr3C6H2, 3g; Ar = 2,6‐iPr‐4‐BrC6H2, 3h) have been synthesized, characterized, and investigated as precatalysts for ethylene polymerization in the presence of modified methylaluminoxane (MMAO). The substituents of α‐diimine ligands and their positions located significantly influence catalyst activity and polymer property. It is found that the catalytic activities of the nickel complex/MMAO systems and the microstructure of the polymer obtained are dominated by not only hindering effect of ortho‐position substituents but also electronical effect of para‐position substituents. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Predicting Skull Loading: Applying Multibody Dynamics Analysis to a Macaque Skull
Authors: Curtis Neil , Kupczik Kornelius , O'higgins Paul , Moazen Mehran , Fagan Michael
Published: April 2008

Evaluating stress and strain fields in anatomical structures is a way to test hypotheses that relate specific features of facial and skeletal morphology to mechanical loading. Engineering techniques such as finite element analysis are now commonly used to calculate stress and strain fields, but if we are to fully accept these methods we must be confident that the applied loading regimens are reasonable. Multibody dynamics analysis (MDA) is a relatively new three dimensional computer modeling technique that can be used to apply varying muscle forces to predict joint and bite forces during static and dynamic motions. The method ensures that equilibrium of the structure is maintained at all times, even for complex statically indeterminate problems, eliminating nonphysiological constraint conditions often seen with other approaches. This study describes the novel use of MDA to investigate the influence of different muscle representations on a macaque skull model (Macaca fascicularis), where muscle groups were represented by either a single, multiple, or wrapped muscle fibers. The impact of varying muscle representation on stress fields was assessed through additional finite element simulations. The MDA models highlighted that muscle forces varied with gape and that forces within individual muscle groups also varied; for example, the anterior strands of the superficial masseter were loaded to a greater extent than the posterior strands. The direction of the muscle force was altered when temporalis muscle wrapping was modeled, and was coupled with compressive contact forces applied to the frontal, parietal and temporal bones of the cranium during biting. Anat Rec, 291:491–501, 2008. © 2008 Wiley‐Liss, Inc.
Expression of SV2 in the Seveloping Chick Cerebellum: Comparison with Calbindin and AMPA Glutamate Receptors 2/3
Authors: Grabs Detlev , Escher Lukas , Bergmann Mathias
Published: April 2008

The well‐organized cerebellum is an ideal model to investigate the developmental appearance and localization of pre‐ and postsynaptic structures. One of the synaptic proteins abundant in the central nervous system and localized in presynaptic vesicle membranes is the synaptic vesicle protein 2 (SV2). SV2 was shown to be involved in priming and modulating synaptic vesicles and having an effect in epileptic diseases. So far there are no data available describing the developmental localization of this protein in the cerebellum. We followed the expression pattern of SV2 and compared it with the expression of the neuronal calcium‐binding protein Calbindin and the AMPA glutamate receptor subunits 2/3 (GluR 2/3), both shown to be early expressed in the developing chick cerebellum predominantly in Purkinje cells. We detected the expression of SV2 in presynaptic terminals (mainly from climbing and mossy fibers) as soon as they are formed at embryonic day 16 in the inner molecular layer. Purkinje cells express Calbindin and GluR 2/3 in the soma and postsynaptically in the primary dendrites at this stage. With ongoing development, the pattern of SV2 expression follows the development of Purkinje cell dendrites in the molecular layer, suggesting a synaptic refinement of labeled climbing and later parallel fibers. Anat Rec, 291:538–546, 2008. © 2008 Wiley‐Liss, Inc.
Exceptionally Long‐Lived Luminescence Emitted from TbIII Ion Caged in an AgI–TbIII–Thiacalix[4]arene Supramolecular Complex in Water
Authors: Iki Nobuhiko , Ohta Munehiro , Horiuchi Takayuki , Hoshino Hitoshi
Published: April 2008

The compositions and photophysical properties of luminescent ternary complexes of thiacalix[4]arene‐p‐sulfonate (TCAS), TbIII, and AgI ions were determined. At pH 6, AgI2⋅TbIII2⋅TCAS2 formed. Moreover, at pH 10, in the presence of a 20‐fold excess of AgI and a 50‐fold excess of TCAS with respect to TbIII, AgI2⋅TbIII⋅TCAS2 formed as the main luminescent species. The structure of these complexes was proposed: two TCAS ligands are linked by two S–AgI–S linkages to adopt a double‐cone supramolecular structure. Furthermore, each TbIII ion in the former complex accepts O−, S, O− donation, whereas in the latter, the TbIII center accepts eightfold O− donation. The luminescence quantum yield (Φ) of AgI2⋅TbIII2⋅TCAS2 (0.16) was almost equal to that of TbIII⋅TCAS, but the luminescence lifetime τ of the former (=1.09 ms) was larger than that of the latter. For AgI2⋅TbIII⋅TCAS2, the yield Φ (=0.11) was small, which is attributed to the low efficiency of photosensitization (η=0.11). However, the τ value (4.61 ms) was exceptionally large and almost equal to the natural luminescence lifetime of TbIII (4.7 ms), which is due to the absence of coordinating water molecules (q=0.1). This is compatible with the proposed structure in which the TbIII ion is shielded by a supramolecular cage that expels coordinated water molecules responsible for luminescence quenching.
Mesoporous Titania Thin Film with Highly Ordered and Fully Accessible Vertical Pores and Crystalline Walls
Authors: Koh Chol‐Won , Lee U‐Hwang , Song June‐Kyu , Lee Hae‐Rim , Kim Min‐Hye , Suh Myungkoo , Kwon Young‐Uk
Published: April 2008

We report the preparation of mesoporous titania thin films with the R$\bar 3$m pore structure derived from the Im$\bar 3$m self‐assembled ordering of the titania species and an EO106PO70EO106 triblock copolymer. The films were spin‐cast and then aged at 18 °C at a relative humidity of 70 %, which led to the orientation of the Im$\bar 3$m structure with the [111] direction perpendicular to the substrates. The [111] body‐diagonal channels became vertical channels upon calcination at 400 °C, thus leading to thin films with vertical channels. The pores are ordered over a large area of up to 1 μm2. The titania films can be formed on various types of substrates. By using a titania film formed on a Pt‐coated Si wafer as a template, we produced by an electrochemical‐deposition technique arrays of gold nanowires, whose morphology suggests that most of the pores of the titania thin films are accessible. The pore structure of vertical channels is stable up to 600 °C, at which temperature the wall materials crystallize into anatase.
Polyhedral Structures with Three‐, Four‐, and Five Fold Symmetry in Metal‐Centered Ten‐Vertex Germanium Clusters
Authors: King R. Bruce , Silaghi‐Dumitrescu Ioan , Uţă Matei‐Maria
Published: April 2008

Studies using density functional theory (DFT) at the hybrid B3LYP level indicate that the relative energies of structures with three‐fold, four‐fold, and five‐fold symmetry for centered 10‐vertex bare germanium clusters of the general type M@Ge10z depend on the central metal atom M and the skeletal electron count. For M@Ge10 clusters with 20 skeletal electrons the DFT results agree with experimental data on the isoelectronic centered 10‐vertex bare metal clusters. Thus the lowest energy structure for Ni@Ge10, isoelectronic with the known Ni@In1010−, is a C3v polyhedron derived from the tetracapped trigonal prism. However, Zn@Ge102+ is isoelectronic with the known cluster Zn@In108−, which has the lowest energy structure, a D4d bicapped square antiprism. For the clusters Ni@Ge102−, Cu@Ge10−, and Zn@Ge10 that have 22 skeletal electrons the lowest energy structures are the D4d bicapped square antiprism predicted by the Wade–Mingos rules. For the clusters Ni@Ge104−, Cu@Ge103−, and Zn@Ge102− that have 24 skeletal electrons the lowest energy structures are C3v polyhedra with 10 triangular faces and 3 quadrilateral faces derived from a tetracapped trigonal prism by extreme lengthening of the edges of the capped triangular face of the underlying trigonal prism. For the clusters Cu@Ge105− and Zn@Ge104− that have 26 skeletal electrons the lowest energy structures are the D5d pentagonal antiprisms predicted by the Wade–Mingos rules and the C3v tetracapped trigonal prism as a somewhat higher energy structure. However, for the isoelectronic Ni@Ge106− the relative energies of these two structure types are reversed so that the C3v tetracapped trigonal prism becomes the global minimum. The effects of electron count on the geometries of the D5d pentagonal prism and D4d bicapped square antiprism centered metal cluster structures are consistent with the bonding/antibonding characteristics of the corresponding HOMO and LUMO frontier molecular orbitals.
ChemInform Abstract: Molecular Dynamics Study of the Stabilization of the Silica Hexamer Si6O156‐ in Aqueous and Methanolic Solutions.
Authors: Caratzoulas S. , Vlachos D. G.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Baeyer—Villiger Oxidation of Ketones Using Molecular Iodine/H2O2 as Heterogeneous Catalytic System.
Authors: Gaikwad Digambar D. , Dake Satish A. , Kulkarni Ravibhushan S. , Jadhav Wamanrao N. , Kakde Shankar B. , Pawar Rajendra P.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mild and Efficient Iodination of Aromatic and Heterocyclic Compounds with the NaClO2/NaI/HCl System.
Authors: Lista Liliana , Pezzella Alessandro , Napolitano Alessandra , d'Ischia Marco
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Inexpensive and Highly Stable Ligand 1,4‐Bis(2‐hydroxy‐3,5‐di‐tert‐butylbenzyl)piperazine for Mizoroki—Heck and Room Temperature Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Mohanty Sasmita , Suresh D. , Balakrishna Maravanji S. , Mague Joel T.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of Chiral Sulfones by Rh‐Catalyzed Asymmetric Addition of Boronic Acids to α,β‐Unsaturated 2‐Pyridyl Sulfones.
Authors: Mauleon Pablo , Alonso Ines , Rivero Marta Rodriguez , Carretero Juan C.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron(III) Amine‐bis(phenolate) Complexes as Catalysts for the Coupling of Alkyl Halides with Aryl Grignard Reagents.
Authors: Chowdhury Rajoshree Roy , Crane Angela K. , Fowler Candace , Kwong Philip , Kozak Christopher M.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Chiral Oxazoline Ligands and Application in the Highly Enantioselective Diethylzinc Addition to N‐Diphenylphosphinoylimines.
Authors: Yan Gexin , Wu Yong , Lin Wenqing , Zhang Xiaomei
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper‐Mediated Synthesis of N,N′‐Diarylhydrazines from Boronic Acids.
Authors: Wang Ye Feng , Zhou Yuan , Wang Jia Rui , Liu Lei , Guo Qing Xiang
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aerobic Oxidation Assisted by Ligand‐Free Palladium Catalysts
Authors: Wang Jia Rui , Yang Chu Ting , Liu Lei , Guo Qing Xiang
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diels—Alder Approach to Tetra‐ortho‐Substituted Biaryls Employing Propargylic Tertiary Alcohols as Dienophiles.
Authors: Ashburn Bradley O. , Carter Rich G.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of S‐Acetyl Oligoarylenedithiols via Suzuki—Miyaura Cross‐Coupling.
Authors: Operamolla Alessandra , Omar Omar Hassan , Babudri Francesco , Farinola Gianluca M. , Naso Francesco
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unexpected Opening of the Benzodiazepine Ring During Acetylation.
Authors: Neochoritis Constantinos , Pozarentzi Minodora , Stephanidou‐Stephanatou Julia , Tsoleridis Constantinos A.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: KF‐Al2O3 Promoted Synthesis of Fully Substituted New Indeno‐ and Naphtho‐Fused Thiophenes under Solvent‐Free Conditions by Controlled Microwave Heating.
Authors: Moghaddam Firouz M. , Saeidian Hamdollah , Mirjafary Zohreh , Sadeghi Azam
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4,8‐Substitutednaphtho[2,1‐b]thiophene Threading Intercalators.
Authors: Badr Sahar , El‐Kerdawy Mohamed M. , Tanious Farial A. , Wilson W. David , Boykin David W.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selenium‐Promoted Synthesis of Enantiopure Pyrrolidines Starting from Chiral Amino Alcohols.
Authors: Tiecco Marcello , Testaferri Lorenzo , Bagnoli Luana , Scarponi Catalina , Temperini Andrea , Marini Francesca , Santi Claudio
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed γ‐Arylation of β,γ‐Unsaturated Ketones: Application to a One‐Pot Synthesis of Tricyclic Indolines.
Authors: Hyde Alan M. , Buchwald Stephen L.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Guanidinium Salt Functionalized PEG: An Effective and Recyclable Homogeneous Catalyst for the Synthesis of Cyclic Carbonates from CO2 and Epoxides under Solvent‐Free Conditions.
Authors: Dou Xiao‐Yong , Wang Jin‐Quan , Du Ya , Wang Er , He Liang‐Nian
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pd(OAc)2‐Catalyzed Synthesis of Heteroaryl‐Substituted 1,8‐Naphthyridine Derivatives via C—N‐Coupling Reactions of Chloronaphthyridines.
Authors: Jin Shou Wen , Liu Bin , Chen Wan Zhi
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Versatile and Diastereoselective Synthesis of Polysubstituted 2‐Oxopiperazines from Naturally Occurring Amino Acids.
Authors: Reginato Gianna , Di Credico Barbara , Andreotti Daniele , Mingardi Anna , Paio Alfredo , Donati Daniele
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2H‐3,1‐Pyrazolo[3,4‐e]oxazines via a New Conversion of Friedlaender Reaction.
Authors: Li Jia Rong , Zhang Li Jun , Chen Jin Nan , Yang Xi Quan , Wang Li Jun , Zhao Xiao Fan , Qiu Jun Xia
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Practical Preparation of β‐Amino‐α‐hydroxy Diesters: Key Intermediates for 1,4‐Oxazin‐2‐ones.
Authors: Elemine Brahim Ould , Besbes Rafaa , Ennigrou Mohamed Rached
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Concise Construction of Novel Bridged Bicyclic Lactams by Sequenced Ugi/RCM/Heck Reactions.
Authors: Ribelin Timothy P. , Judd Andrew S. , Akritopoulou‐Zanze Irini , Henry Rodger F. , Cross Jeffrey L. , Whittern David N. , Djuric Stevan W.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformation of Indoline Spiropyrans to Bridged 1,3‐Benzoxazepino[3,2‐a]indoles via Carbanions Stabilized by a Cyano Group.
Authors: Sackus A. , Valaityte E. , Amankaviciene V. , Berg U. , Schicktanz C. , Schlothauer K.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selenium‐Containing Tetrachalcogenins and Pentachalcogenepins Fused to Aromatic Systems.
Authors: Alam Ashraful , Ogawa Satoshi , Muraoka Hiroki , Kon‐no Masaru , Nakajo Shiduko , Sato Ryu
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient Microwave‐Assisted Synthesis of Subphthalocyanines
Authors: Giribabu L. , Kumar Ch. Vijay , Surendar A. , Reddy V. Gopal , Chandrasekharam M. , Reddy P. Yella
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Squaraine‐Based Near‐Infrared Dye with Bright Fluorescence and Solvatochromic Property.
Authors: Umezawa Keitaro , Citterio Daniel , Suzuki Koji
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Guajadial: An Unusual Meroterpenoid from Guava Leaves Psidium guajava
Authors: Yang Xiao‐Long , Hsieh Kun‐Lung , Liu Ji‐Kai
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Glycosylated N‐Sulfonylamidines: Highly Efficient Copper‐Catalyzed Multicomponent Reaction with Sugar Alkynes, Sulfonyl Azides, and Amines.
Authors: Mandal Santanu , Gauniyal Harsh Mohan , Pramanik Kausikisankar , Mukhopadhyay Balaram
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Organocatalytic Anomerization of α‐C‐Glycosylmethyl Aldehydes and Ketones.
Authors: Massi Alessandro , Nuzzi Andrea , Dondoni Alessandro
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Triterpene Glycoside (Ia) from Sea Cucumber Holothuria leucospilota.
Authors: Han Hua , Yi Yang Hua , Li Ling , Wang Xiao Hua , Liu Bao Shu , Sun Peng , Pan Min Xiang
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polyhydroxylated Pyrrolizidines. Part 9. A New Synthetic Approach to (+)‐Hyacinthacine A1 (Ia) and the First Total Synthesis and Absolute Configuration Assignment of Naturally Occurring (+)‐Hyacinthacine A6 (Ib).
Authors: Izquierdo Isidoro , Plaza Maria T. , Tamayo Juan A. , Sanchez‐Cantalejo Fernando
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the ABC‐ (I) and D‐Ring Systems (II) of the Indole Alkaloid Ambiguine G (III).
Authors: Chandra Aroop , Viswanathan Rajesh , Johnston Jeffrey N.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Flavonoids and a Naphthopyranone from Eriocaulon ligulatum and Their Mutagenic Activity.
Authors: da Silva Marcelo Aparecido , Oliveira Ana Paula Siqueira , Sannomiya Miriam , Sano Paulo Takeo , Varanda Eliana Aparecida , Vilegas Wagner , dos Santos Lourdes Campaner
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spirastrellolides C to G: Macrolides Obtained from the Marine Sponge Spirastrella coccinea.
Authors: Williams David E. , Keyzers Robert A. , Warabi Kaoru , Desjardine Kelsey , Riffell Jenna L. , Roberge Michel , Andersen Raymond J.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electronic and Magnetic Properties of Bimetallic Ytterbocene Complexes: The Impact of Bridging Ligand Geometry
Authors: Carlson Christin N. , Veauthier Jacqueline M. , John Kevin D. , Morris David E.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Weak Attractive Ligand—Polymer and Related Interactions in Catalysis and Reactivity: Impact, Applications, and Modeling
Authors: Chan Michael C. W.
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Hydrogenation of Heteroaromatic Compounds
Authors: Zhou Yong‐Gui
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Construction of a Chiral Central Nervous System (CNS)‐Active Aminotetralin Drug Compound Based on a Synthesis Strategy Using Multitasking Properties of (S)‐1‐Phenylethylamine.
Authors: Federsel Hans‐Juergen , Hedberg Martin , Qvarnstroem Fredrik R. , Sjoegren Magnus P. T. , Tian Wei
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Functionalization of Phthalocyanines and Subphthalocyanines by Transition‐Metal‐Catalyzed Reactions
Authors: Martinez‐Diaz M. Victoria , Quintiliani Maurizio , Torres Tomas
Published: April 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.