bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating Clad Formations in Directed Energy Deposition Process Using a Dimensionless Analysis
Authors: Lim Choon Wee Joel , Zhang Yanmei , Huang Sheng , Chan Wai Lee
Published: March 2022

The growing interest in the directed energy deposition process in different industries has warranted a deeper understanding in the properties of the basic building block of the method: clad formation. In this study, the clad formation obtained by depositing stainless steel 316L (SS316L) powder with different laser traverse speed, laser power, and powder flow rate, were investigated. Repeatability was ensured through a wide sample range per parameter. The clad showed an increase in height with an increase in powder flow rate and a decrease in traverse speed. A deeper melt pool was formed with a higher laser power. Dimensionless analysis suggested that these effects of the parameters generally scale with a non-dimensional combination of the process parameters considered, which can be easily determined before printing and hence practical for applications. The analysis also revealed that different regimes of clad formation can be demarcated by the linear energy density, another term that relies only on process parameters that are prescribed. A critical linear energy density for printing of SS316L clads in this study was observed, below which resulted in poor adhesion to the substrate with occasional delamination. Interestingly, once the critical linear energy density was met, regardless of the variations in one or more of the parameters, there was generally no difference in hardness except for a few cases. These anomalies were further investigated using the electron back scattered diffraction technique, which illustrated how the microstructure of a clad will affect its macroscopic property such as hardness. With its ability to extract a wealth of insights, the procedure from this work will be useful for obtaining a range of optimal process parameters based on the type of application that is required of a directed energy deposition process.
Risk of Kidney Injury Requiring Dialysis After Sepsis
Authors: Wong Chung-Shun , Chen Tzu-Ting , Hu Ping-Jen , Wu Mai-Szu , Wu Mei-Yi
Published: March 2022

Background:Sepsis-associated acute kidney injury (AKI) can accelerate the progression of chronic kidney disease and lead to permanent kidney damage. However, the relationship between sepsis-associated AKI and dialysis has not been well evaluated. Our study aimed to investigate the risk of AKI requiring dialysis after sepsis.Methods:A nationwide population-based case-crossover study comprised all patients requiring their first dialysis from 2004 to 2016 from the database of Taiwan’s National Health Insurance. Patients aged <20 years or with missing data were excluded.Results:147,201 and 75,031 patients requiring acute temporary and chronic dialysis were included in this study. The odds ratios (ORs) for patients requiring acute temporary dialysis after sepsis were 15.77, 10.67, 9.23, and 8.36 for exposure periods of 1, 2, 3, and 4 weeks, respectively. For patients requiring chronic dialysis after sepsis, ORs were 6.99, 4.12, 4.16, and 3.66 for exposure periods of 1, 2, 3, and 4 weeks, respectively. In analyses using no overlapping time intervals, the risk remained the highest during the time closest to the event.Conclusions: This study demonstrated that patients with sepsis had a markedly increased risk of renal failure requiring dialysis and the risk was highest within 1 week of sepsis.
Viscoelastic characterization and degradation stability investigation of poly(butylene-adipate-co-terephthalate) – calcium-phosphate glass composites
Authors: Toglaitti Elena , Milanese Daniel , Pugliese Diego , Sciancalepore Corrado
Published: March 2022

In this work new biodegradable composite materials based on poly(butylene-adipate-co-terephthalate) (PBAT) reinforced with calcium-phosphate glass (CPG) microparticles at different filler concentration (0, 4, 10, 20 and 40 wt%) were characterized by dynamic-mechanical analysis (DMA), ageing and fragmentation tests. DMA results showed increasing storage modulus (E’) values with the filler content, without a significant modification of the glass transition temperature (Tg), translating in a reinforcing effect of the filler particles with good interphase adhesion. The creep compliance decreased with the increase of the CPG content, confirming a greater resistance of the composites to deformation under constant stress. The stability to weathering agents and the degree of fragmentation in laboratory-scale composting conditions were also tested, obtaining a higher sensitivity to degradation of the PBAT-based composites with the increase of CPG content. Overall, the addition of CPG particles in a PBAT matrix produced stiffer composites, with modulation of the properties based on the filler content, enhancing at the same time their degradation rate, making them a promising and more sustainable alternative to traditional polymers.
Study on the influence of F16 fault on rockburst
Authors: Rong Hai , Pan Liting , Wang Yadi , Yu Shiqi , Guo Kaipeng , Li Nannan
Published: March 2022

In order to solve the safety problem of rockburst in coal mining under fault conditions and realize safe and efficient production of coal mine, this paper analyzes the existing mechanism and geological environment of fault, constructs fault monitoring scheme and field construction method, and carries out underground monitoring of F16 fault. The stress and displacement of F16 fault in Gengcun Coal Mine are monitored, the deformation and activity of the fault are analyzed, and the influence on energy when the stress and displacement change is observed. The experimental results show that : Before and after the two large energy microseismic events, the stress and displacement changed significantly, and the energy increased first and then decreased sharply. The mining of working face had an important impact on the activity of F16 fault. The deep mining of coal mine would disturb the coal seam and roof and floor strata, destroy the stress state of the original rock mass, increase the in-situ stress, complicate the geological structure, and develop various faults one after another, It will destroy the integrity and integrity of the coal seam, cause the destruction of surrounding rock near the fault, release energy, cause large energy microseismic events, and in serious cases, it will lead to rockburst accidents. The research results have guiding significance for monitoring the impact of F16 fault activity on Rockburst in Gengcun Coal Mine, and provide experimental methods and theoretical basis for other coal mines to study the change process of energy during fault activity.
Biosynthesis of Silica Nanoparticles Using Leaf Extract of Punica Granatum and Assessment of Its Antibacterial Activities Against Human Pathogens
Authors: Periakaruppan Rajiv , Priya C , Ranjitha P , Danaraj Jeyapragash
Published: March 2022

Plant-mediated nanoparticle synthesis is a revolutionary technique with numerous applications in agriculture, food processing, and medicine. This present study reports Punica granatum leaf extract is capable of the green and eco-friendly synthesis of silica nanoparticles which provides simple, cost effective, and efficient methodology. Silica nanoparticles were synthesized by a biological method using Tetra Ethyl Ortho Silicate. Biosynthesized silica nanoparticles characterized by X-Ray Diffraction Analysis, Scanning Electron Microscopy, Energy Dispersive X-Ray Spectroscopy, and Fourier Transform Infrared Spectroscopy. All the analysis and characterization were determined that particles were spherical, amorphous nature with an average size of 12 nm. P. granatum assisted silica nanoparticles were tested for antibacterial activity by well diffusion method against two-gram negative bacterial pathogens (E. coli and Salmonella Sp.). The antibacterial studies prove that P. granatum assisted silica nanoparticles to have good antibacterial properties. These studies will help to find a new nano drug or medicine for multidrug-resistant bacteria.
Does antenatal supplementation with omega-3 affect child development and behavior during the first six months of life? A randomized double-blind placebo-controlled trial
Authors: de Sousa Taciana Maia , Santos Luana Caroline dos
Published: March 2022

Purpose
This randomized double-blind placebo-controlled trial aimed to evaluate the effect of antenatal omega-3 supplementation on child development and behavior during the first six months of life.
Methods
Participants with gestational age between 22–24 weeks were randomized in placebo (olive oil; n = 30) or omega-3 (fish oil; n = 30) groups and supplemented until childbirth. Fish oil capsules provided 1440mg/day of DHA. Child development was assessed using the Survey of Well-being of Young Children in the first, fourth and sixth month of life. Intention-to-treat and per-protocol analyses were performed using Generalized Estimating Equations.
Results
The comparison between groups showed no differences in the Developmental Milestones score at any time, but when compared to the first month, the omega-3 group showed an increase at the fourth and sixth month. Such increase was not observed in the placebo group. No differences were found between groups for Irritability and Inflexibility scores, however, higher scores for Difficulty with Routine were observed in the placebo group when compared to omega-3 at first, fourth and sixth month.
Conclusion
There were no differences between groups for child development, but the omega-3 group showed an increase in this score over time. The placebo group had greater difficulty with routine than the omega-3 group, indicating a beneficial effect of antenatal supplementation on child behavior.
Trial registration:
ReBec U1111-1215-7952 (June 16th 2018).
Short-term Passenger Flow Prediction of railway epidemic Based on SARIMA - LSTM combined model
Authors: WEI Shu-yao , ZHANG Jin
Published: March 2022

The huge disturbance caused by the sudden outbreak of COVID-19 to the short-term passenger flow of railway. The daily passenger flow curves of periodic and seasonal non-stationary time series of Spring Festival travel under the COVID-19 pandemic were analyzed, and the combined model based on SARIMA-LTSM was constructed. SARIMA model was used to predict the linear part and LSTM rolling optimization model was used to predict the nonlinear part. Finally, the two prediction results were put into the weighted sum of attention mechanism module, and the GRU gated loop unit was introduced to assist verification. Through case study and analysis, the results show that the prediction results of SARIMA-LTSM combined model have good control and high accuracy, which can provide theoretical basis for the close representation and prediction of short-term passenger flow data set of epidemic emergencies.
Phytochemicals as Potential Inhibitors for COVID-19 Revealed by Molecular Docking, Molecular Dynamic Simulation and DFT Studies
Authors: Puthanveedu Vinduja , Muraleedharan Karuvanthodi
Published: March 2022

The COVID-19 pandemic outbreak demands the designing of potential drugs as there is no specific treatment available. Thanks to their safety and effectiveness, phytochemicals have been used to treat various diseases, including antiviral therapeutics. Molecular docking is a simple, quick, and effective way to screen a variety of molecules for structure-based drug design. Here, we investigate molecular docking experiments on compounds present in plant species, C.hirsutus and R.rosea and show their potential for the treatment of COVID-19. Almost all the components showed higher binding energies than the built-in ligand, and those with significantly higher binding energies were explored further. Molecular mechanics-based generalized born surface area calculations were used to re-rank the top candidates, rhodionidin and cocsoline, and their stability in association with viral protease was confirmed. Density functional theory was used for detailed investigations of the geometries, electrical properties, and molecule electrostatic potential of rhodionidin and cocsoline. Using the frontier molecular orbitals method, the charge transfer within the molecule was calculated. Chemical reactivity and intermolecular interactions were studied using molecular electrostatic potential maps. These in silico discoveries will simulate the identification of powerful COVID-19 inhibitors, and similar research is likely to make a significant contribution to antiviral drug discovery.
Weyl interface states in non-Hermitian synthetic dimension
Authors: Song Wange , Chen Yuxin , Wu Shengjie , Chen Chen , Huang Chunyu , Yuan Luqi , Zhu Shining , Li Tao
Published: March 2022

Synthetic dimension has emerged as an attractive concept to explore higher-dimensional physics, yet they are usually formed by Hermitian degrees of freedom. Here, we establish a new platform of non-Hermitian synthetic dimension with unprecedented flexibility to investigate the non-Hermitian Weyl physics. The interface modes between two Weyl media of different non-Hermitian topological structures (i.e., Weyl point and Weyl exceptional ring) are explored. Specifically, we construct a spatially modulated silicon waveguide array with well-controlled chromium deposition, creating the non-Hermitian synthetic dimension, where the interface states induced by imaginary mass inversion are predicted and observed in integrated photonic experiments. Besides, it is found that the interface states can also appear with the shift/deformation along non-Hermitian synthetic dimensions according to the phase transition crossing the Weyl exceptional ring. Our work connects the concept of synthetic dimension with the non-Hermitian scope, which remarkably enriches the physics of topological states as well as phase transitions, and implies potentials in chip-scale photonics manipulations.
Analysis of Anti-malarial drug-resistant genes of Plasmodium falciparum 3D7 to understand its expression: the bioinformatics approach
Authors: Waktole Gemechis , Donghee Cho
Published: March 2022

Malaria is one of the most important infectious diseases that threaten half of the world’s population. Ethiopia is among countries with a high malaria burden. Plasmodium falciparum is the most common (64%) cause of malaria in Ethiopia while P. vivax accounts for the remaining cases (34%). Despite numerous advances in malaria control strategies, the disease still kills countless children worldwide, mainly in sub-Saharan African countries and malaria still remains a major public health problem in Ethiopia. Analyzing parasite genetics has enormous potential to aid both efforts at elimination as well as international efforts toward eradication. Therefore, this study is aimed to insilico analysis of regulatory elements such as CpG islands, transcription factors (TFs) and their corresponding binding sites (TFBSs) involved in the regulation of gene expression of Plasmodium falciparum 3D7 isolates drug resistant genes. In this analysis nine drug resistance affecting gene coding sequences, available in NCBI database with the start codon at the beginning of the sequence and only functional genes (protein coding) were deliberated. Accordingly, the promoter prediction by neural network promoter prediction result showed Plasmodium falciparum 3D7 drug resistance affecting genes have 1–6 TSS and five common candidate motifs (MPfI, MPfII, MPfIII, MPfIV and MPfV) were identified. The study indicates the poor occurrence of CpG islands in both gene body and promoter regions which may affect the access of promoter region of genes to their transcription factors, hence affecting their expression. In general, this in silico analysis of genes encoding for Plasmodium falciparum drug resistance affecting genes could be helpful to add knowledge about the molecular data and supportive to identify gene regulatory elements in the promoter regions.
Quantum Annealing with Special Drivers for Circuit Fault Diagnostics
Authors: Leipold Hannes , Spedalieri Federico
Published: March 2022

We present a very general construction for quantum annealing protocols to solve Combinational Circuit Fault Diagnosis (CCFD) problems that restricts the evolution to the space of valid diagnoses. This is accomplished by using special local drivers that induce a transition graph on the space of feasible configurations that is regular and instance independent for each given circuit topology. Analysis of small instances shows that the energy gap has a generic form, and that the minimum gap occurs in the last third of the evolution. We used these features to construct an improved annealing schedule and benchmarked its performance through closed system simulations. We found that degeneracy can help the performance of quantum annealing, especially for instances with a higher number of faults in their minimum fault diagnosis. This contrasts with the performance of classical approaches based on brute force search that are used in industry for large scale circuits.
Role of cyclic adenosine monophosphate-response element binding protein in hypertonic-induced cell injury in human lens epithelial cells
Authors: Zhao Peiquan , Xiao Dong , Zhang Qiqiang , Ye Qing , Xu Yu , Zhu Maolin , Wang Xiaohan , Jin Haiying
Published: March 2022

Purpose: Diabetic cataracts is one of the complication of diabetes mellitus which contributes to the opacification of the lens and blindness by hurting lens epithelial cells (LECs). The hypertonic environment due to the high blood glucose level is a most important reason of LECs injury in diabetes mellitus. However, the mechanism of LEC self-regulation under a hypertonic condition is still not fully understood. This study aims to investigated the function of cyclic adenosine monophosphate-response element binding protein (CREB) and its related mitogen-activated protein kinase (MAPK) pathways, mitochondria-related proteins in regulating of cell viability process of LECs, under hypertonic conditions.Method: We exposed lens epithelial cells to hypertonic conditions to detect the activation of CREB and MAPK pathways and the changes of mitochondrial related proteins in cells,to verify the effect of CREB on cell injury under hypertonic conditionsResults: We found that CREB can attenuate LEC cell viability under hypertonic conditions. Additionally, we found that the activation of proteins in MAPK and apoptosis-related pathways may be responsible for the cellular signaling mechanism of CREB-mediated protection.Conclusion: CREB protects LECs against the hypertonic solution-induced damage by suppressing p53-mediated mitochondria-dependent apoptotic signaling. In addition, activation of extracellular signal-regulated protein kinase 1/2, p38 MAPKs, and B-cell leukemia/lymphoma 2 expression may underlie CREB-mediated protection.
Stereotactical Normalization with Multiple Templates Representative of Normal and Parkinson-Typical Reduction of Striatal Uptake Improves the Diagnostic Power of Automatic Semi-Quantitative Analysis in Dopamine Transporter SPECT
Authors: Apostolova Ivayla , Schiebler Tassilo , Lange Catharina , Mathies Franziska Lara , Lehnert Wencke , Klutmann Susanne , Buchert Ralph
Published: March 2022

Background
The specific binding ratio (SBR) of 123I-FP-CIT in the putamen is widely used to support the interpretation of dopamine transporter (DAT) SPECT. Automatic methods for computation of the putamen SBR often include stereotactical normalization of the individual DAT-SPECT image to an anatomical standard space. This study compared using a single 123I-FP-CIT template image as target for stereotactical normalization versus multiple templates representative of normal and different levels of Parkinson-typical reduction of striatal 123I-FP-CIT uptake.
Methods
123I-FP-CIT SPECT images of 1738 patients (66.2 ± 11.6y) were stereotactically normalized (affine) to the anatomical space of the Montreal Neurological Institute (MNI) with SPM12 either using a single custom-made FP-CIT template representative of normal striatal uptake or using eight different templates representative of normal and different levels of Parkinson-typical reduction of striatal FP-CIT uptake with and without attenuation and scatter correction. In the latter case, SPM finds the linear combination of these templates that best matches the patient’s image. The putamen SBR was obtained using hottest voxels analysis in large unilateral regions of interest predefined in MNI space. The histogram of the putamen SBR in the whole sample was fitted by the sum of two Gaussian functions. The power to differentiate between reduced and normal SBR was estimated by the effect size of the distance between the two Gaussian functions computed as the differences between their mean values scaled to their pooled standard deviation.
Results
The effect size of the distance between the two Gaussian functions was 3.84 with the single template versus 3.96 with multiple templates for stereotactical normalization.
Conclusions
Multiple templates representative of normal and different levels of Parkinson-typical reduction for stereotactical normalization of DAT-SPECT provide improved separation between normal and reduced putamen SBR, suggesting slightly improved power for the detection of nigrostriatal degeneration.
An Open-Label, Randomized Pharmacokinetic Study of Two Formulations of Eldecalcitol Capsules Following Single Oral Administration in Healthy Chinese Volunteers Under Fasting and Fed Conditions
Authors: WU JUAN , Fan Yuru , Zheng Liang , Liu Yueyue , Zhang Qian , Zhao Hui , Shen Chenlin , Hu Wei
Published: March 2022

Purpose
Eldecalcitol is an active vitamin D3 derivative for preventing and treating osteoporosis. The objectives of this study was to evaluate the bioequivalence and safety of two formulations of eldecalcitol capsule (0.75 µg) in healthy Chinese male and female volunteers, as well as to investigate the food effect on the pharmacokinetics.
Methods
An open-label, randomized, three-period, three-sequence, reference-replicated crossover clinical study was performed in 27 healthy Chinese volunteers under fasting condition. Meanwhile, a two-way crossover study was performed in 28 healthy Chinese volunteers under fed condition. Subjects were administered with a single oral dose of 0.75 µg eldecalcitol after an overnight fast. The washout time between each period was 25 days. Blood samples were collected with scheduled time points from 0 to168 h.
Results
The 90% confidence intervals (CI) of test/reference AUC ratio and Cmax ratio of the eldecalcitol were within the acceptance criteria based on average bioequivalence method. Tmax of test and reference formulation were 3.987 h and 3.489 h under the fasting conditions. While Tmax was prolonged to 9.006 h and 6.007 h in test and reference formulation after a high-fat meal. Only mild and transient, but not severe adverse events were detected in the study.
Conclusion
Two formulations of eldecalcitol was bioequivalent under both fasting and fed conditions. Whereas, food intake prolonged the oral absorption of eldecalcitol, but did not significantly influence the system exposure.
A case of Sheehan syndrome six years postpartum with hypothyroidism and mild hyponatremia
Authors: Mishra Priya , Jindal Himanshu , Khan Efa , Palawat Sandeep Singh
Published: March 2022

Sheehan syndrome, also referred to as postpartum hypopituitarism is often a sequela of massive post-partum hemorrhage in resource poor healthcare settings where blood loss during delivery is often neglected. The diagnosis of this rare but fatal is disease is often delayed because the symptoms are vague and the pituitary dysfunction is insidious in nature. This condition sometimes takes more than a decade before it is diagnosed. The classic signs and symptoms include agalactia, secondary amenorrhea and dry wrinkling skin. Often an empty or a partially empty sella is seen on magnetic resonance imaging of the brain. We present the case of a 35-year-old multiparous female with anhedonia and raised serum transaminases who presented to our side with mild hyponatremia and hypothyroidism. She got diagnosed with Sheehan syndrome at our set up six years after her last obstetric event. Through this case report, we intend to provide a clinical account of the patient’s condition and management.
Skin cultivable bacterial of Melanophryniscus admirabilis (admirable red belly toad): the role of bacterial communities on species conservation
Authors: Ienes-Lima Julia , Prichula Janira , Abadie Michelle , Borges-Martins Márcio , Frazzon Ana Paula Guedes
Published: March 2022

Melanophryniscus admirabilis is a small toad, critically endangered with a microendemic distribution in the Atlantic Forest in southern Brazil. The amphibian skin microbiome is considered one of the first lines of defense against pathogenic infections, such as Batrachochytrium dendrobatidis ​(​Bd​). The knowledge of skin amphibian microbiomes is important to numerous fields, including species conservation, detection and quantification of environmental changes and stressors. In the present study, we investigated, for the first time, cultivable bacteria in the skin of wild M. admirabilis, and addressed the ability of these bacterial populations to protect the toads against pathogens, such as Bd fungus. Skin swabs were collected from 15 wild M. admirabilis, and the samples were processed for culture study and presence of Bd fungus by nested-PCR. A total of 62 bacterial isolates being Bacillus (n=22; 34.48%), Citrobacter (n=10; 16.13 %), and Serratia (n=12; 19.35%) were more frequently isolated genera. Interestingly, all skin samples tested were Bd negative. Some bacterial genera identified in our study might be acting in a synergic relationship and protecting them against the Bd fungus. In addition, these bacteria may play an essential role in maintaining this species in an environment modulated by anthropic actions. This first report of skin cultivable bacteria from M. admirabilis natural population improves our knowledge of skin amphibian microbiomes, contributing to a better understanding of their ecology and how this species has survived in an environment modulated by anthropic action.
Development and Validation of a RNA Binding Protein-Associated Prognostic Model for Uterine Corpus Endometrial Carcinoma
Authors: Yao Yong , Liu Kangping , Wu Yuxuan , Zhou Jieyu , Jin Heyue , Zhang Yimin , Zhu Yumin
Published: March 2022

BackgroundThe dysregulation of RNA binding proteins (RBPs) is involved in tumorigenesis and progression. However, information on the overall function of RBPs in Uterine Corpus Endometrial Carcinoma (UCEC) remains to be studied. The aims of this study were to explore the associated molecular mechanisms and to develop an RNA binding protein-associated prognostic model for UCEC.MethodsBased on The Cancer Genome Atlas (TCGA) database, differentially expressed RBPs were identified between UCEC tumor tissues and normal tissues. Hub RBPs were then found by univariate and multivariate Cox regression analysis. The cBioPortal platform, R packages (DESeq2, edgeR and ggplot2) and The Human Protein Atlas (HPA) online database were used to explore the molecular mechanisms of UCEC. Kaplan-Meier (K-M), Area Under Curve (AUC), and the consistency index (c-index) were used to test the performance of our model.ResultsIn total, 128 differentially expressed RBPs between UCEC tumor tissues and normal tissues were identified. Seven RBP genes (NOP10, RBPMS, ATXN1, SBDS, POP5, CD3EAP, ZC3H12C) were screened as prognostic hub genes and used to construct a prognostic model, which are particularly important to prospectively predict patient prognosis and help them get treatment accordingly. Further analysis indicated that the patients in the high-risk subgroup had poor overall survival (OS) compared to those in low-risk subgroup based on the model. We also established a nomogram based on seven RBPs, which potentially improved individualized diagnostic and therapeutic strategies for UCEC.ConclusionOur work focused on the systematic analysis of a large cohort of patients in the TCGA database, which allowed us to construct a robust prognostic model based on seven RBPs, that may be of great value in clinical applications.
Exploring Public and Private Hospital-Based Health Information Technology: A Cross-Sectional Study in Hospitals in the Municipality of Lubango-Angola
Authors: Sanjuluca Tomas Hambili , Almeida Anabela , Correia Ricardo
Published: March 2022

The availability of information has a significant impact on the management of health organizations, mainly when it is used for decision-making. For information to be available in a timely and reliable manner, these organizations must have a proper information system effectively used. The objective of this study was to be exploring the level of use of information technology (IT) supporting information systems management in public and private health sector located in the municipality of Lubango, Angola. That is a descriptive cross -sectional study based on a questionnaire applied to ten hospital administrators of private-public health organizations situated in Lubango. The questionnaire focuses on the profile and organization of each health institution and IT usage. The results show that 70% of all the health institutions studied do not have a department responsible for information technology. Most hospital departments do not have specific clinical software. In 80% of health organizations studied, the accounting and finance area has software and Internet access. The study has identified the lack of Health Information Technology in hospitals province of Huila is low or even non-existent. Furthermore, the most significant focus of information management based on information technology is concentrated on administrative and financial information management and not uses in clinical information systems (electronic patient records). This supports other studies that indicate that health care managers are adopting low-cost IT electronic health information systems. This study is the first conducted in this health region of Angola that assesses the reality of public and private health organizations in using information technologies to support the management of hospital information systems. With the patient, the hospital's mission, the results of this study can awaken managers to the need to use IT to manage clinical information.
Anisotropic index strength behavior and failure mode validation of weathered shale
Authors: Abbas Hasan Ali
Published: March 2022

The failure mode limitations presented in the International Society for Rock Mechanics (ISRM) were recognised as an obvious issue by invalidating most of the failure modes along the bedding plane. In this study, the anisotropic behaviour of index strength and failure mode of weathered shale are evaluated by utilising the point load test (PLT) and the block punch index (BPI). The outcomes elaborate that the degree of anisotropy of PLT is four times the BPI degree of anisotropy. The failure mode of weathered shale is observed to be controlled by the bedding plane orientation (β). Particularly, when the point loading is not perpendicular to the bedding plane orientation, it is necessary to consider the inclined failure mode along bedding since eliminating these results may cause a significant over-prediction of index strength. Meanwhile, the presence of secondary failures along a bedding in weathered shale under BPI is because of the normal stress distribution. Consequently, the very low bonding between the bedding planes is not able to resist the tensile stresses developed at the specimen faces during punching. The study also highlighted the effect of the horizontal angle of bedding orientation (θ) with respect to the puncher.
Isolation of angiolipoma tissue sections with Color-Based Segmentation Using K-Means Clustering
Authors: Radak Mahyar
Published: March 2022

In this paper, we used Color-Based Segmentation Using K-Means Clustering using an intelligent tissue filtering algorithm to identify tissue-based image regions containing thick-walled capillaries with fibrin clots, between mature lipocytes and fibrin septum, and HE angiolipoma spots. Our algorithm for segmentation on the image of tissue impregnated with hemotoxylin and eosin (H&E). This staining method helps pathologists identify different types of tissue. This algorithm was able to identify and extract angiolipoma tissue nuclei and isolate nuclei and tissues attached to angiolipoma nuclei from the whole image.
RIS-Assisted Multi-User MIMO-DQSM Transmission System
Authors: Castillo-Soria Francisco R. , Kumaravelu Vinoth Babu , Azurdia-Meza Cesar A. , Sim´on Jorge , Gutierrez Carlos
Published: March 2022

This paper presents a reconfigurable intelligent surface (RIS) assisted multi-user (MU) multiple-input multiple-output (MIMO) system. Instead of being applied at the remote RIS, the phase shift vector is applied at the base station (BS) by using an additional precoding stage. The overall system performance is improved by incorporating a double quadrature spatial modulation (DQSM) transmission technique. Results show that the proposed system has gains of up to 17 dB in bit error rate (BER) and a reduction in detection complexity of 51% when compared with the conventional MU-MIMO system based on spatial multiplexing (SMux). Compared with a similar system based on amplify and forward (AF) relay-assisted technique, the proposed system has up to 18 dB gain in BER performance under the same conditions and parameters. Mainly, the proposed system significantly reduces the signal processing required at the RIS.
PPT1 Deficiency-Induced GABAAR Hyperpalmitoylation Impairs Synaptic Transmission and Memory Formation
Authors: Tong Jia , Gao Jingjing , Feng Bingyan , Zhao Xing , Li Junmei , Qi Yawei , Zhang Qiuyu , Lu Chengbiao , Peng Shiyong
Published: March 2022

Palmitoylation is a reversible and dynamic process involving addition of palmitic acid to cysteine residues of proteins. Studies have indicated that a variety of neuronal receptors, including glutamate receptors such as AMPAR, NMDAR, and GABAAR, are palmitoylated, which contributes to the dynamic modulation of synaptic strength in response to neuronal activity. However, little is known about the depalmitoylation of these receptors. In this study, we adopted PPT1-deficient mice, an animal model that closely mimics human disease of infantile neuronal ceroid lipofuscinosis (INCLs), by knocking in a CLN1 c.451C > T nonsense mutation. We identified for the first time that the GABAARα1 subunit rather than AMPAR is the substrate of PPT1. In PPT1-deficient mice, we found the excessive palmitoylation and extended membrane location of GABAAR. Miniature inhibitory postsynaptic current (mIPSC) recorded from CA1 pyramidal neurons of PPT1-KI mice was also enhanced without disturbance of excitatory neuronal transmission. Spatial learning and memory deficits with enhancement of γ oscillation while attenuation of phase coupling was shown in the mice at as early as 2-month-old. Application of N-tert-butylhydroxylamine hydrochloride, a thioesterase mimetic, attenuated PPT1 mutation-induced GABAAR hyperpalmitoylation and its membrane accumulation with improved neuronal transmission and memory functions in the mice. These data provide new insights into the mechanisms of neuronal disorder caused by depalmitoylation deficiency and offer a clue for further intervention for INCLs and other neurodegenerative diseases.
Elevated Expression of The RNA-Binding Protein IGF2BP1 Enhances The Mrna Stability and Translation Efficiency of INHBA to Promote The Invasion and Migration of Esophageal Squamous Cancer Cells
Authors: Wang Juan-Juan , Chen Ding-Xiong , Zhang Yu , Xu Xin , Cai Yan , Hao Jia-Jie , Wang Ming-Rong
Published: March 2022

Background: The mechanisms underlying the occurrence and development of esophageal squamous cell carcinoma (ESCC) remains to be elucidated. The present study aims to investigate the roles and implications of IGF2BP1 overexpression in ESCC.Methods: IGF2BP1 protein expression in ESCC samples was assessed by immunohistochemistry (IHC), and the mRNA abundance of IGF2BP1 and INHBA was analyzed with TCGA datasets and by RNA in situ hybridization (RISH). Cell viability, migration, invasion and in vivo metastasis assays were performed to explore the roles of IGF2BP1 overexpression in ESCC. RNA immunoprecipitation sequencing (RIP-seq) and mass spectrometry were applied to identify the target RNAs and interacting proteins of IGF2BP1, respectively. RIP-PCR, RNA pulldown, immunofluorescence (IF), gene-specific m6A PCR and RNA stability assays were used to uncover the molecular mechanisms underlying the malignant phenotypes of ESCC cells caused by IGF2BP1 dysregulation. The methylation level of the IGF2BP1 promoter region was detected by methylation-specific PCR (MSP-PCR). Results: IGF2BP1 overexpression was detected in ESCC tissues and associated with the depth of tumor invasion. Knockdown of IGF2BP1 inhibited ESCC cell invasion and migration as well as tumor metastasis. Mechanistically, we observed that IGF2BP1 bound and stabilized INHBA mRNA and then enhanced the translation of INHBA, leading to the activation of Smad2/3 signaling, thus promoting malignant phenotypes. The mRNA level of INHBA was upregulated in ESCC tissues as well. Furthermore, IGF2BP1 interacted with G3BP stress granule assembly factor 1 (G3BP1) and activated the INHBA-Smad signaling. In addition, IGF2BP1 mRNA expression in ESCC cells was negatively correlated with the level of its promoter methylation.Conclusions: Elevated expression of IGF2BP1 is a frequent event in ESCC tissues and might be a candidate biomarker for the disease. IGF2BP1 overexpression promotes the invasion and migration of ESCC cells by activating the INHBA-TGF-β-Smad2/3 pathway, providing a potential therapeutic target for ESCC patients with high expression of IGF2BP1.
Analysis on the Impact of Taiwan Far-field Earthquakes on the Disaster Avoidance Behavior of People in High-rise Buildings in Large Cities in Southeast China
Authors: dongping li , Qingquan Tan , Jinfei Yin , yibo jian
Published: March 2022

Taiwan Province is an earthquake-prone area, and strong earthquakes in Taiwan could affect coastal cities in the mainland. The high-rise buildings in coastal cities often are seriously affected, which can cause social panic. Therefore, it is necessary to study the seismic impact of moderate and strong earthquakes in Taiwan on the mainland coast to accurately analyze the effect on buildings in this area, especially the responses of people in high-rise buildings after the earthquake, and to provide a relatively accurate reference for the evaluation of the timely restoration of social order. This paper uses the 43.29 million mobile phone location records collected after the M6.1 earthquake in Hualien, Taiwan on April 18, 2021, for the bandwidth selection in kernel density estimation in different regions and conducts a quantitative density analysis of 331 buildings using the communication check-in data after the earthquake on different temporal and spatial scales. Through this work, an exponential model of people’s responses in high-rise buildings to far-field strong earthquakes in Taiwan is obtained, and the flow pattern of people in regard to disaster avoidance in high-rise buildings after far-field nondestructive earthquakes is summarized. This paper can be a reference for the local government to judge the impact of Taiwan's far-field earthquakes and to make decisions with respect to disaster relief.
LANGUAGE DISCRIMINATION AND POLITICAL CORRECTNESS IN THE GERMAN LANGUAGE
Authors: Ermolenko Svetlana , Turchyn Karina
Published: March 2022

This article is about discrimination in linguistic and political correctness in the language, where words, expressions are used that a certain group of people in different areas, e.g. related to nations, religion, skin color, age, disadvantage or gender, can offend or offend. For almost forty years, political correctness has shaped many languages, taking more and more expressions and replacing them with others that do not sound so offensive, but which are also viewed as censorship and can violate the freedom of the press. This cultural-linguistic, linguistic-historical contribution focuses on aspects that provide insights into the linguistic use of four terms “Sinti”, “Roma”, “Jenische” and “Zigeuner”. The purpose of the analysis is to illustrate the way in which the phenomenon of this minority is expressed in the literary examples and in a political speech. It also shows the historical background that contributed to the fact that the use of the word is different today. Linguistic discrimination is first implicitly prepared in thought and action and then leads to racist verbal utterances. If some terms in classical works were perceived as acceptable, they sound racist today because, after many centuries of use, they are connotatively negatively charged with many historical events. When talking about Roma, Sinti and Yenish, historical external names on the one hand and contemporary self-names on the other hand must be distinguished, whereby the word “Zigeuner” nowadays has to bear the full weight of the tragedy of this largest minority in Europe.
Espiritualidad como soporte para docentes universitarios en tiempos de la COVID-19
Authors: Parada-Rico Doris Amparo , Lozano-Cárdenas Félix , Bautista-Rodríguez Luz Marina
Published: March 2022

El objetivo planteado es identificar el nivel de espiritualidad en docentes universitarios durante el contexto de la pandemia. Se utilizó la metodología cuantitativa descriptiva correlacional con pruebas U de Mann-Whitney, rho de Spearman y H de Kruskal-Wallis en 85 docentes universitarios de las facultades de Salud y Humanidades de un ente público. Aplicada la escala de espiritualidad, se analizó la información mediante SPSS, versión 24. Los resultados evidencian altos niveles de espiritualidad en 96% de docentes. Existen diferencias estadísticamente significativas de las puntuaciones respecto a la edad y el sexo en la dimensión necesidades espirituales, siendo los hombres y el grupo entre 30 y 39 años los que presentaron mayor promedio (p<0,05). La dimensión autoconciencia predominó en el nivel más alto. Conclusiones: la espiritualidad, como una construcción dada a partir de creencias, prácticas y experiencias propias, representa un elemento relevante para el cuidado del ser, considerándola fundamental para enfrentar dificultades, sobre todo en situaciones aparentemente disruptivas tales como la COVID-19. En la vivencia de la pandemia, los docentes adoptan la espiritualidad como una parte de su ser que otorga valor a sí mismos y orienta la búsqueda de armonía con la naturaleza y el enfoque en sus metas.
Índices de shock y shock modificado en el puerperio inmediato
Authors: Rivas-Perdomo Édgar , Puello Mestre Agustín
Published: March 2022

Los parámetros que definen el shock ―como taquicardia, hipotensión y pobre perfusión del órgano final― no son totalmente aplicables a la paciente obstétrica por los cambios fisiológicos que dificultan establecer puntos de corte para desencadenar intervenciones clínicas. Sin embargo, una relación de ellos puede generar un indicador más preciso de hipovolemia llamado índice de shock (IS) e índice de shock modificado (ISM). Se realizó un estudio de corte transversal con el objetivo de establecer la mediana del IS y del ISM, desviación estándar (DS) e intervalo de confianza del 95% (IC95), a los 30 minutos, a la hora y a las dos horas. Los valores en los diferentes momentos se compararon con un test de ANOVA y de acuerdo con la vía del parto mediante rangos de Wilcoxon. Se calcularon coeficientes de correlación de Spearman entre el ISM, la edad de las pacientes y la edad gestacional. Las medianas del IS y del ISM fueron de 0,669 (DS: 0,014; IC95: 0,664-0,692) y 0,922 (DS: 0,019; IC95: 0,914-0,949), respectivamente. No se encuentra ninguna correlación de estos valores con las edades de las pacientes o la edad gestacional.
PREVALENCE OF RISK FACTORS AND COMORBID CONDITIONS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
Authors: Jain Abhishek , Singh Lalit , Agrawal Anurag , Tandon Rajeev , Agrawal Nipun
Published: March 2022

Introduction: COPD is associated with several risk factors and co morbid conditions. Dealing

with co-morbidity needs a patient centered approach, rather than a disease oriented approach7.

The present study was conducted to study risk factors and co morbid conditions of COPD

patients.

Material and Methods: The present study was conducted in department of Pulmonary

Medicine at Shri Ram Murti Smarak Institute of Medical Sciences with respiratory complaints

over a period of one and a half year. The data was collected in terms of demographic features,

anthropometric measurements and various risk factors and co morbid conditions. Spirometry

was performed thrice and the largest values of both FVC and FEV1 were noted from three

technically satisfactory curves. COPD severity was classified based on Spirometric

assessment according to the GOLD classification. Categorical variables were analyzed using

proportions and percentages.

Results: In a study of 201 cases that were diagnosed as a case of COPD the mean age was 62.6

years and male predominance. Majority of the patients had sedentary life style and were from

poor class. The co morbid conditions anemia, cardiac, hypertension, diabetes mellitus, lipid

disorders, thyroid disorders, osteoporosis, psychiatric illness, ophthalmic defects and

obstructive sleep apnea was found in 43.8%, 52.2%, 65.2%, 52.2%, 51.7%, 64.7%, 72.1%,

66.7%, 28.9% and 54.2% respectively.

Conclusion: Co morbidities should be taken into consideration while prescribing multiple

drugs so that side effects and interactions of drug can be monitored and quality of life can be

improved.
Compounding for survival. The Catholic gentry during the English Revolution
Authors: Geraerts Jaap
Published: March 2022

Review of Eilish Gregory, Catholics during the English Revolution, 1642-1660. Politics, sequestration and loyalty (Woodbridge: The Boydell Press, 2021, viii + 248 pp., index)
Willem Lodewijk van Nassau-Dillenburg. Stadhouder, militair en ‘family man’
Authors: Prak Maarten
Published: March 2022

Review of Hanno Brand en Joop W. Koopmans, red., Willem Lodewijk: Stadhouder en strateeg (1560-1620-2020) (Hilversum: Verloren, 2020, 191 p., ill., index)
Exploring the Equity Impact of Current Digital Health Design Practices: Protocol for a Scoping Review
Authors: Evans Laura , Evans Jay , Pagliari Claudia , Källander Karin
Published: March 2022

Background

The field of digital health has grown rapidly in part due to digital health tools’ potential to reduce health inequities. However, such potential has not always been realized. The design approaches used in digital health are one of the known aspects that have an impact on health equity.

Objective

The aim of our scoping review will be to understand how design approaches in digital health have an impact on health equity.

Methods

A scoping review of studies that describe how design practices for digital health have an impact on health equity will be carried out. The scoping review will follow the methodologies laid out by Arksey and O’Malley, the Joanna Briggs Institute, and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. The PubMed, Embase, Web of Science, and ACM Digital Library databases will be searched for peer-reviewed papers. The ProQuest Dissertations and Theses and Global Index Medicus databases will be searched for gray literature. The results will be screened against our inclusion and exclusion criteria. Subsequently, the data extracted from the included studies will be analyzed.

Results

As of March 2022, a preliminary search of the peer-reviewed databases has yielded over 4900 studies, and more are anticipated when gray literature databases are searched. We expect that after duplicates are removed and screening is completed, a much smaller number of studies will meet all of our inclusion criteria.

Conclusions

Although there has been much discussion about the importance of design for lowering barriers to digital health participation, the evidence base demonstrating its impacts on health equity is less obvious. We hope that our findings will contribute to a better understanding of the impact that design in digital health has on health equity and that these findings will translate into action that leads to stronger, more equitable health care systems.