bluuebunny/crossref_metadata_2025 huggingface dataset:
La palabra sagrada. Violencia y lenguaje en Balún-Canán
Authors: Mosqueda Rivera Raquel
Published: January 2019

El presente trabajo indaga en el itinerario seguido en Balún-Canán, novela emblemática de la narradora mexicana Rosario Castellanos, por dos elementos en apariencia contrarios: la violencia y el lenguaje. Dicho recorrido atraviesa por varios “momentos” en los cuales se ponen en evidencia una serie de desencuentros entre la palabra escrita y la palabra oral, así como las distintas dimensiones que los protagonistas de esta novela otorgan, por un lado al “uso de la palabra”, y, en el otro extremo, a una de las formas más representativas de la violencia: “el uso del silencio”. Por tanto, el lenguaje no constituye únicamente una forma de dominio, sino una dimensión espaciotemporal donde callar adquiere múltiples sentidos.
Fleeting Encounters & Brick walls: Animating Embodied Literacies in Our Everyday Relations
Authors: Bell Rachel , Copage Katelyn , Rogers Matt , Whitty Pam
Published: January 2019

Rachael, Katelyn, Pam and Matt take up Sara Ahmed’s (2012) concepts of fleeting encounters and brick walls as they reflect on the feminist and decolonizing nature of their work. This paper is the product of months of conversation between the co-authors. Through the use of autoethnographical and participatory approaches, the authors seek to invite the reader into a co-constructed space where mutual support and inspiration shape the future actions of the participants as they grapple with their ethical responsibilities as learners and educators.
Creating New Meanings and Understanding with Postcolonial Texts: Teaching Purple Hibiscus in a Grade 10 Classroom
Authors: McBean Kevin , Johnston Ingrid
Published: January 2019

This article invites readers to share the experiences of a teacher and his Grade 10 students as they read and discussed Chimamanda Ngozi Adichie’s Nigerian novel Purple Hibiscus. The novel was selected as part of a national action research study in which literacy researchers and teachers select postcolonial literature for the classroom and develop new pedagogical strategies for teaching the texts. The article suggests that contemporary international novels such as Purple Hibiscus have potential to raise complex questions of social justice in the classroom and to create new understandings of a changing world.
Relationship of Traffic Noise with High Blood Pressure to Pedicab Drivers Around Purabaya Bus Station Surabaya
Authors: Addina Shita , Keman Soedjajadi
Published: January 2019

Abstract: The existence of bus  station  can  make  some problems, one  of which  is the traffic noise. Traffic noise  can induce an increased blood pressure. Therefore, the purpose of this study was to analyzed the relationship  between level of traffic noise  and increased blood  pressure in pedicab drivers around Purabaya bus station. The study was carried out using  by cross sectional method. Measurement of traffic noise  was carried out around  Purabaya bus station Surabaya with Sound Level Meter. Measurement of blood  pressure with sphygmomanometer. Sampling method used by simple random  sampling with 22 respondents respectively and  then  total of respondents are 44 respondents. The  result of study  indicated there  was  a relationship  between the level traffic noise  with increased blood  pressure (hypertension) (p = 0.034). Another factor related to blood  pressure was descendants of the family history (p = 0.002). It was concluded that traffic noise  related with increased blood pressure in pedicab drivers. Suggested for the next researcher doing  the measurement noise  more than a day to get the actual average noise  level. In addition, other factors related to the blood pressure should examined to get main factor of hypertension.Keywords: traffic noise, blood  pressure, pedicab drivers
Cytokines and atherosclerosis – new research directions
Authors: Dutova V. S. , Saranchina J. V. , Karpova M. R. , Kilina O. Yu. , Polshcha N. G. , Kulakova T. S. , Khanarin N. V.
Published: January 2019

This review generalizes the current evidence on the content of the pro- and anti-inflammatory cytokines in patients’ blood serum with atherosclerotic lesions of the coronary, carotid and iliac arteries. The results gave the ability to assess cytokine immune cells of atherosclerotic plaques. Also the results of national and international research allowed the assessment of the prognostic value of cytokine content.
Relations of existential characteristics and hardiness with psychosomatic cardiac symptoms in young people
Authors: Grigoriev P. E. , Vasilieva I. V.
Published: January 2019

Objective. Evaluation of the psychological well-being and hardiness in adolescents with cardiac symptoms.

Materials and methods.The study involved 80 people aged 18–24 years, a relatively healthy sample. To assess the existential characteristics, the scale of psychological well-being of С. Ryff in the adaptation of N.N. Lepeshinsky. To assess the psychological quality of hardiness, the S. Maddi questionnaire was used in adaptation D.A. Leontiev, E.I. Rasskazova. To assess the psychosomatic component of cardiac symptoms the Giessen questionnaire of psychosomatic complaints was used. Descriptive statistics methods, the Mann – Whitney test for independent samples, a one-way analysis of variance with a posteriori pairwise comparison using the Newman-Keuls test were used.

Results.For members of the healthy sample at the age of 18–24 years, the severity of psychosomatic cardiac complaints is relatively homogeneous by sex and age; the most significant differences in existential characteristics and hardiness in connection with the severity of psychosomatic cardiac symptoms fall on indicators of “commitment”, “control”, “environmental management”. Conclusion. The most significant and discriminating contribution to the prevention of psychosomatic cardiac complaints is such existential and stress-coping characteristics of personality as the ability to effectively use life situations to achieve one’s own goals, to fight for success and get results from their actions, to strive for maximum involvement in the activities of interest for the reflected, conscious meaning in life.
Clinical description of affective disorders and efficiency of antidepressant therapy
Authors: Lebedeva E. V. , Schastnyy E. D. , Simutkin G. G. , Repin A. N. , Nonka T. G.
Published: January 2019

Objective:to identify the structure and clinical features of affective disorders (AD) and efficiency of antidepressants in in-patients with chronic coronary artery disease (ChCAD), living in Tomsk and the Tomsk Region.

Materials andмethods.At a heart center, 1,131 patients with ChCAD were examined: in 290 persons (25.6%) AD were revealed, among them 72.1% were men (n= 209) and 27.9% were women (n= 81). Mean age of women was (63.5 ± 9.4) years and in men (57.9 ± 7.2) years (р= 0.004). AD structure, main syndromes, severity of depression and anxiety according to data of self-questionnaires and clinical scales before and after antidepressant therapy (predominantly with selective serotonin reuptake inhibitors (SSRI)) were studied. Comparative analysis of clinical indices of CAD respective from AD, presence of antidepressant therapy and its efficiency was performed.

Results.Chronic AD were found in 45% of patients. Newly diagnosed depressive episodes made up 24.5% and recurrent depressive disorder (RDD) was 24%. 6.5% were bipolar affective disorders (BAD), predominantly bipolar II disorders. Depressive syndrome in 91.7% of patients had the second significant component (more frequently 54.8%). Characteristic of the clinical picture was dominance of complaints of bodily discomfort and pain, anergy and anhedonia. Moderate mental disturbances made up 49.0% (CGI). AD manifested at the age of 48 (40–55) years and preceded development of ChCAD. Natural course of AD was observed in 52.4% of cases. 47.6% (138/290) of patients received antidepressants, and only in 42% (58/138) clinically significant improvement was noted (more than 50% according to CGI). It was difficult to encourage patient adherence to long-term therapy (30–50% according to CGI). Physical activity tolerance (PAT) according to data of veloergometry increased in responders. Psychopharmaco- and psychotherapy should be included into rehabilitative programs for patients with ChCAD and AD.
Proteostatic Signaling & Control of Protein Synthesis
Authors: Keefe AJ
Published: January 2019

The tremendous diversity and complexity of proteins invariably results in protein misfolding, to which cells have evolved numerous mechanisms of mitigating. Degrading misfolded proteins is perhaps the most intuitive strategy, but also critical to managing proteostasis are the elaborate mechanisms of translational control. Attenuated rates of translation ameliorate protein misfolding by downregulating the flux of new protein and conserving ATP. Loss of translational control, particularly in neurons, constitutes a major proteostatic dysfunction capable of causing or exacerbating neurodegeneration, while interventions aimed at downregulating protein synthesis are generally neuroprotective. In this review, I examine the critical neuronal signaling networks employed to control translation with an emphasis on current research. This includes the Unfolded Protein Response (UPR), the mitochondrial UPR (mtUPR), mTORC1 signaling, and stress granule formation.
Linguistic Missing Links: Instruction in Decrypting, Translating and Transliterating the Only Document Known to Use Both Proto-Romance Language and Proto-Italic Symbols for Its Writing System
Authors: Cheshire Gerard Edward
Published: January 2019

This paper provides the solution to understanding the hitherto unknown writing system used for the manuscript listed as MS 408 at the Beinecke Library, Yale University. The writing system uses symbols, punctuation, grammar and language that are each unique. The manuscript is not encrypted, in the sense that its author made an effort to conceal the contents of the manuscript, as has been presumed by some scholars. Instead, it is code only in the sense that the modern reader needs to be versed in the calligraphic and linguistic rules to be able to translate and read the texts. Furthermore, in discovering its writing system, it became apparent that the manuscript is of invaluable importance to the study of the evolution of the Romance languages and the scheme of Italic letters and associated punctuation marks now commonplace in those and other modern languages. In short; it is revealed to be the only known document both written in Vulgar Latin, or proto-Romance, and using proto-Italic symbols. The original title for the manuscript, given by its female author, is: What one needs to be sure to acquire for the evils set in one’s fate. It is a book offering homeopathic advice and instruction to women of court on matters of the heart, of sexual congress, of reproduction, of motherhood and of the physical and emotional complications that can arise along the way through life.       The manuscript has now been dated to the year 1444 and the location of its creation has been pinpointed to the court of Castello Aragonese, on the island of Ischia: as expounded in the companion paper Linguistically Dating and Locating Manuscript MS408: http://ling.auf.net/lingbuzz/003808.
The Impact of Valsartan/Amlodipine Single-Pill Combination on Blood Pressure and Vascular Stiffness in Patients with Grade 1-2 Essential Arterial Hypertension
Authors: Borisova E. V. , Kochetkov A. I. , Ostroumova O. D.
Published: January 2019

Aim. To investigate the impact of valsartan/amlodipine single-pill combination (V/A SPC) on arterial stiffness parameters and 24-hours blood pressure (BP) level in the middle-aged patients with stage II grade 1-2 essential arterial hypertension (HT). Material and methods. A group of patients with stage II grade 1-2 HT who had not previously received regular antihypertensive therapy (n=38, age 49.7±7.0 years) was retrospectively formed. All the patients were treated with V/A SPC and all of them achieved target office BP (<140/90 mm Hg). 12 weeks after reaching the target BP the assessment of V/A SPC therapy effectiveness and vascular stiffness (general clinical data, ambulatory BP monitoring, volume sphygmography, echocardiography) were performed in all included HT patients. Sex- and age-matched healthy people with normal BP (n=86, age 48.8±5.8years) and in whom similar clinical and vascular stiffness data were available represented a control group. Results. According to the ambulatory BP monitoring data systolic, diastolic and pulse BP significantly (p<0.001) decreased after the treatment with V/A SPC. Volume sphygmography has showed significant decrease in right-CAVI value from 8.9±1.3 to 7.3±1.4 (p=0.021) as well as a reduction the number of patients with a right- and/or left-CAVI>9.0 from 31.6 to 10.5% (p=0,049). According to an assessment of arterial stiffness the augmentation index decreased significantly by 23.6±8.6% from -23.0±17.1 to -28.9±18.7 (p=0.034. Transthoracic echocardiography data has demonstrated decrease in effective arterial elastance from 1.73±0.35 to 1.60±0.32 mm Hg (p=0.016) and increase in the arterial compliance – from 1.30±0.38 to 1.43±0.34 mm Hg/ml (p=0.049). Conclusions. In naive patients 40-65 years old with stage II grade 1-2 HT antihypertensive therapy with V/A SPC provides effective 24 hours BP control and improves arterial stiffness parameters.
Evaluation of Drug Therapy and Adherence to It in Patients after Acute Coronary Syndrome in Real Clinical Practice (Results of One Year Observation)
Authors: Khaisheva L. A. , Glova S. E. , Suroedov V. A. , Samakaev A. S. , Shlyk S. V.
Published: January 2019

Aim. To study the prescribed drug therapy, as well as adherence to it in patients with acute coronary syndrome (ACS) in real clinical practice within a year after the index event. Material and methods. The study included 327 patients who were in hospital treatment with ACS: 199 patients (60.9%) with unstable angina (UA) and 128 (39.1%) – with acute myocardial infarction (AMI). The prescribed treatment and adherence to therapy were evaluated within 12 months after the coronary event. Therapy prescribed to patients was compared with current clinical guidelines for the treatment of patients with ACS. Results. 67% of patients completed the clinical study Adherence to prescribed medication within 12 months after ACS was maximal for ACE inhibitors/angiotensin receptor blockers (83.6%), dual antiplatelet therapy (79.9%) and β-blockers (78.1%), and minimal for lipid-lowering drugs (statins; 61.6%). A significant decrease in adherence was revealed in 6 and 12 months from the initiation of therapy. Significantly higher level of adherence to DAT was found in patients with AMI compared with patients with UA (p<0.05). When analyzing the frequency of occurrence of endpoints, it was found that patients who did not adhere to treatment significantly more often had hospitalizations due to UA (15.1% vs 7.4%; p<0.05), AMI (16.9% vs 8.1%; p<0.05), death from cardiovascular causes (13% vs 10.4%; p<0.05). Conclusion. Therapy prescribed at the outpatient stage in patients with ACS in the Rostov Region corresponds to the modern clinical recommendations. Six months after hospital discharge adherence to drug therapy in patients is reduced, which requires more careful outpatient monitoring during this period. In patients who are not adherent to treatment, cardiovascular complications are significantly more frequent.
Assessment of in Vitro Comparative Dissolution Kinetics of Moxonidine Products as a Factor Potentially Determining Effectiveness of Antihypertensive Treatment
Authors: Ramenskaya G. V. , Shokhin I. E. , Gaponova N. I. , Abdrakhmanov V. R.
Published: January 2019

Aim. Investigation of comparative dissolution kinetics of generic medicinal products containing moxonidine versus reference drug. Material and methods. Objects of the research were film-coated tablets containing moxonidine (INN) in a dose 0.4 mg: a reference drug Physiotens® and 4 generic drugs. In vitro dissolution test of moxonidine from the study drugs was performed using comparative dissolution kinetics test (CDKT). The CDKT was performed in the media with the following pH: 1.2 (1:9 mixture of 0.1 M hydrochloric acid and water), 4.5 (acetate buffer solution, prepared as per State Pharmacopoeia, XIII), and 6.8 (phosphate buffer solution, prepared as per State Pharmacopoeia, XIII). The sampling for dissolved moxonidine was performed 5, 10, 15, 20, and 30 min after the test was started. An high performance liquid chromatography method with ultraviolet detection at 220 nm was used to assay. Results. Within 15 min more that 85% of moxonidine dissolved from the reference drug and all study drugs at pH 1.2; dissolution profiles were similar without calculation of similarity factor f2. Similarly, at pH 4.5 dissolution profiles of study drugs #2 and #3 were similar to that of the reference drug, and the similarity factor f2 was not calculated. However, in case of study drugs #1 and #4 significant differences were observed at a single time point (15 min), which suggests that their dissolution profiles are non-similar to that of the reference drug. Similarity factors f2 were calculated 17.52 and 35.30, respectively (less than 50). At pH 6.8 similarity factors f2 for all study generic drugs were also less than 50 (23.8, 49.8, 38.6, and 35.9), so their dissolution curves were non-similar to that of reference drug. Conclusion. In our study we observed difference in release in vitro of medicinal products containing moxonidines: none of the study drugs was fully similar to the reference drug in all media. The differences observed at pH 6.8 were noteworthy, where the samples had or faster kinetics (study drugs #2 and #3), or slower dissolution kinetics (test drugs #1 and #4). Observed differences in moxonidine release rate may impact absorption of active pharmaceutical ingredient into the blood following drug administration.
A Double-blind Randomized Comparative Clinical Trial to Evaluate the Safety and Efficacy of Dendritic Cell Vaccine Loaded with WT1 Peptides (TLP0-001) in Combination with S-1 in Patients with Advanced Pancreatic Cancer Refractory to Standard Chemotherapy
Authors: Katsuda Masahiro , Miyazawa Motoki , Ojima Toshiyasu , Katanuma Akio , Hakamada Kenichi , Sudo Kentaro , Asahara Shingo , Endo Itaru , Ueno Makoto , Hara Kazuo , Yamada Suguru , Fujii Tsutomu , Satoi Sohei , Ioka Tatsuya , Ohira Masaichi , Akahori Takahiro , Kitano Masayuki , Nagano Hiroaki , Furukawa Masayuki , Adachi Tomohiko , Yamaue Hiroki
Published: January 2019

Background: Pancreatic cancer is a refractory malignancy and the development of a new effective treatment strategy is needed. We generated a dendritic cell vaccine by culturing monocytes obtained by apheresis of blood from each patient, inducing their differentiation into dendritic cells, and pulsing with tumor antigen peptides. However, the clinical efficacy of the vaccine has not been established. We therefore decided to conduct an exploratory clinical trial of dendritic cell vaccine loaded with Wilms’ tumor gene 1 peptides (TLP0-001) as a potential new treatment for patients with advanced pancreatic cancer refractory to standard chemotherapy.
Methods: This is an investigator-initiated double-blind comparative trial. The patients were allocated to two groups in a 1:1 ratio through a central registration by dynamic allocation. A total of 185 patients with inoperable or metastatic pancreatic cancer who were refractory or intolerant to standard primary chemotherapy with gemcitabine plus nab-paclitaxel will be allocated to secondary treatment either with placebo in combination with S-1 (the control group) or TLP0-001 in combination with S-1 (the investigational product group). The primary objective of this trial is to evaluate the safety and efficacy (as measured by overall survival) of the investigational product by comparing the two groups. This clinical trial will be performed in accordance with Japanese Good Clinical Practice guidelines.
Discussion: Clinical trials of the standard regimen, including gemcitabine, for advanced pancreatic cancer are ongoing worldwide. However, a strategy for after the primary treatment has not been established. We therefore decided to conduct this study to evaluate the safety and efficacy of TLP0-001 as a secondary treatment for pancreatic cancer in anticipation of the approval of this new drug in Japan. This trial is conducted with full consideration of safety as it is the first-in-human clinical trial of TLP0-001; thus, the trial will be conducted only at the Second Department of Surgery at Wakayama Medical University until the safety is confirmed by interim analysis. We plan to conduct a multicenter trial at 18 institutions in Japan after confirmation of the safety.
Ultrasound-guided deep nerve block may increase the rate of local anesthetics toxicity in HBV carriers: A Randomized clinical trial
Authors: Zhang Xu-hao , Li Yu-jie , He Wenquan , Yang Chunyong , Gu Jianteng , Lu Kaizhi , Yi Bin
Published: January 2019

Background: Ultrasound-guidance might decrease the incidence of local anesthetics systemic toxicity(LAST) for many peripheral nerve blocks compared to nerve stimulation. However, it remained uncertain whether ultrasound-guidance would be superior to the nerve stimulation for deep nerve block in the lower extremity. This study was designed to investigate that deep nerve block with ultrasound-guidance would result in a lower rate of LAST comparing to that with nerve stimulator-guidance.
Methods: Three hundred patients who were for elective lower limb surgery and desiring lumbar plexus blocks(LPBs) and sciatic nerve blocks(SNBs) were enrolled in this study. Patients were randomly assigned to receive LPB and SNB with ultrasound-guidance (Group U), nerve stimulator-guidance (Group N) and dual-guidance (Group M). The primary outcome was the incidence of the LAST. The secondary outcomes were number of needle redirections, motor and sensory block onset and restoration times in the nerve distributions, and associated risk factors.
Results: There were 18 patients with the LAST, including 12 in group U, 4 in group N and 2 in group M. For multiple comparisons among the tree groups, we found that the incidence of LAST in group U(12%) was significantly higher than that in group N(4%)(P=0.037) and group M(2%)(P=0.006). The OR of LAST with HBV infection and female gender was 3.352(95% CI,1.233-9.108, P=0.013 ) and 9.488(95% CI,2.142-42.093, P=0.0004), respectively.
Conclusions: For patients undergoing LPBs and SNBs, use of ultrasound may increase the incidence of the LAST. HBV infection and female gender were risk factors for deep nerve block.
Trial registration: This study was approved by the human research review committee at the southwest hospital of third military medical university. The protocol was registered prospectively with Chinese Clinical Trial Registry (ChiCTR-IOR-16008099) on March 15th，2016.
Keywords: Ultrasound; nerve stimulation; nerve block; female; HBV; LAST
THE ROLE OF LEADER’S SPIRITUAL LEADERSHIP ON ORGANISATION OUTCOMES
Authors: Phuong V. Nguyen  , Khoa T. Tran  , Khanh Hai Dao  , Ho Phi Dinh
Published: January 2019

This paper aims to investigate a causal model of spiritual leadership theory in organisational context and evaluates the effectiveness of spiritual survival and empowerment on organisational outcomes in terms of commitment and citizenship behaviour. It used structural equation model (SEM) approach to test a conceptual framework with data collection of 329 full-time employees working in service industries in Ho Chi Minh City, Vietnam. The findings illustrated the critical effects of spiritual leadership on organisational outcomes throughout membership, empowerment, and personal characteristics regarding meaning and calling. Specifically, a qualitative approach was conducted to highlight the testing results and get a better understanding of unanticipated consequences from the quantitative analysis. Based on the findings, the study proposed some specific interests of managerial implications and identify some limitations for future study.
Betonun Elastisite Modülünün Agrega/Kayaç Özelliklerinden Tahmini
Authors: TEYMEN Ahmet
Published: January 2019

Bu çalışma, agrega malzemelerinin sağlam kayaçlarının fizikomekanik özelliklerinin betonun mukavemet performansı (elastisite) üzerindeki etkisini incelemektedir. Bu amaçla çeneli kırıcı kullanılarak dokuz farklı agrega üretilmiş ve bu agregalar dokuz farklı betonun üretiminde kullanılmıştır. Betonların yapımı sırasında, su-bağlayıcı oranları, çökme ve işlenebilirlik temelinde, 0,28 ile 0,55 arasında tutulmuştur. Agrega ve kayaç özelliklerini belirlemek için toplam on yedi test yapıldı. Betonların elastisite modüllerini (Ec) tahmin etmek için basit ve çoklu doğrusal regresyon analizleri (SPSS) gerçekleştirilmiş ve denklemlerin doğruluğu F ve t-testi ile test edilmiştir. 28 günlük kür süresine göre, ilgili agrega kayaçlarının fizikomekanik özellikleri ile Ec arasında güçlü korelasyonlar elde edilmiştir. Bu çalışmanın sonuçlarından %72,2-%98,2 aralığında değişen yüksek korelasyon katsayılı basit denklemler elde edildiğinden, Ec parametresi ile kayaçların mühendislik özellikleri arasında iyi ve güvenilir ilişkiler olduğu belirlenmiştir. Ayrıca, çoklu regresyon modelleri, basit modellerden daha iyi bir tahmin verimliliğine sahiptir ve Ec’yi yeterli bir güvenirlikle tahmin etmek için uygulanabilirler. 
Betonarme Yapıların Deprem Etkisi Altında Performans Analizlerinin Yapılması ve Güçlendirilmesi
Authors: YÜZBAŞI Jülide , YERLİ Hüseyin R.
Published: January 2019

Ülkemiz üzerinde etkin fay hatlarının bulunduğu bir yapıya sahiptir. Yaşanılan son depremler ülkemizde inşa edilmiş birçok yapının gerekli deprem güvenliği koşullarını sağlayamayacak düzeyde olduğunu göstermiştir [1-4]. Bu durum mevcut yapıların dinamik etki altındaki davranışlarını incelemeyi gerekli kılmaktadır. Bu çalışmada, mevcut yapılar sahip oldukları fiziksel koşullar göz önünde bulundurularak modellenmiş ve günümüz şartlarında farklı deprem düzeyleri etkisi altındaki performansları analiz edilmiştir. FEMA-356’ya paralel olarak revize edilen Türk Deprem Yönetmeliği’ne (TDY-2007) dayanan bir performans değerlendirmesi yapılmıştır [5-6]. Yapılan performans analizleri sonucunda yapıların depreme karşı yeterliliği ve yapıldığı dönem sonrasında meydana gelmiş olan gelişmelere uygunluğu irdelenmiştir. Performans yetersizliği durumunda, yapı emniyeti ve ekonomik koşullar dikkate alınarak, yapıya uygulanacak işlemler hakkında verilecek en uygun kararın ne olduğu belirlenmiştir. Mevcut yapıların deprem durumunda güvenli olup olmadığı kontrol edilmiştir. Gerekli hallerde güçlendirme çalışmalarının projelendirilmesi yapılmıştır [7]. Böylelikle ileride yaşanabilecek can ve mal kayıplarının önlenmesi amaçlanmıştır.
The Relationship Between Perceived Social Support in Pregnancy and Self-Efficacy for Childbirth Fear - A Cross-Sectional Study in Arak City, 2017
Authors: Vakilian Katayon , Zarin Fatemeh , Zaraj Hoda
Published: January 2019

Background:

It seems that with perceived social support, self-efficacy for childbirth fear can be strengthened in pregnant women. The present study aimed to investigate the relationship between perceived social support in pregnancy and self-efficacy for childbirth fear in Arak.

Methods:

This cross-sectional study was conducted on 180 pregnant women. Sampling was done on convenience and health centers were selected randomly. After receiving written consent, the standard questionnaire of perceived social support and the self-efficacy for childbirth fear was given to pregnant women. The questionnaires were collected immediately after completion. After collecting the data, the information was entered into the spss18 software and the Pearson test was used for data analysis.

Results:

The mean score of self-efficacy for childbirth fear, and perceived social support were 34.55±8.183, 23.93±11.047 respectively. Also, there was no correlation between self-efficacy for childbirth fear and family, friends, and others perceived social support (p >0.05).

Conclusion:

From the results it seems that the subjective evaluation of the individual from her supporters during pregnancy is not effective on self-efficacy for childbirth fear which is subjective as well. Therefore, health providers should involve directly the husband and the wife’s family regarding supporting the pregnant woman during prenatal care.
Health-Related Quality of Life and Associated Factors Among People Living with HIV /AIDS Following ART Clinic in Jimma University Specialized Hospital, Southwest Ethiopia: A Facility- Based Cross-Sectional Study
Authors: Tesfaye Tamiru , Darega Jiregna , Belachew Tefera , Abera Abebe
Published: January 2019

Background:

HIV care of people living with HIV /AIDS (PLWH/A) is critical for fruitful HIV inhibition, treatment and provision of quality of life. The goal of Anti-Retroviral Therapy (ART) is to suppress viral replication, lessen morbidity and death, and improve patients’ quality of life. The quality of life of HIV/AIDS patients is not well appraised in the study area beforehand. Therefore, this study assessed the health-related quality of life and associated factors among people living with HIV /AIDS followed by ART Clinic in Jimma University Specialized Hospital, Southwest Ethiopia.

Methods:

We used facility based cross-sectional study design and 351 samples selected by systematic random sampling from Jimma University Specialized Hospital ART clinic in March-2014. Data were collected through interviewer-administered questionnaires and analyzed by using SPSS version 20.0 software. Descriptive analysis (frequency and percentage) was calculated. Bivariate and multivariate analyses were used to identify associated factors. The association between the explanatory and dependent variables was assessed at p-value of less than 0.05. The results were presented in a narrative form, tables and graphs.

Results:

From the total respondents, 143 (40.7%) of them have low quality of life in general. Of these, 238 (67.8%) of them had low psychological domain, 136 (38.7%) had low physical domain and 223 (63.5%) low social domain. The age ≤ 39 years (AOR = 2.381 [95% CI = 1.238, 4.579]), Currently employed (AOR= 3.509 [95% CI = 1.900, 6.482]), current CD4 count ≥ 250 cell/ml (AOR = 2.663 [95% CI = 1.363,5.203]), current WHO Stage I-II (AOR = 4.772 [95% CI = 2.308, 9.865]), good general health condition (AOR = 2.609 [95%CI = 1.372, 4.961]), no comorbidity (AOR = 7.737 [95% CI = 4.146, 4.438), friendly social relationship (AOR = 5.395 [95% CI = 2.781, 10.467]), other persons reminded their drugs took time (AOR = 3.363 [95% CI = 1.629, 6.943]) and drunk alcohol (AOR = 1.915[95% CI = 1.039, 3.529]) were identified as the predictors of health related quality of life.

Conclusion:

Findings of this study indicate that the significant number of participants exists on low-level- of health related quality of life in general. The age, occupation, current CD4 count level, current WHO stage status, general health conditions, comorbidity conditions, status of their social relations, their conditions due to lack of support, reminder of drugs taking time, and alcohol drinking status have been observed to have a statistically significant association with their health-related quality of life status.
ANALYSIS	OF	FACTORS	AFFECTING	BEHAVIORAL	INTENTION	OF	NURSING STUDENT	AS	BYSTANDER	CARDIOPULMONARY	RESUSCITATION	(CPR)	ON HANDLING	OUT	OF	HOSPITAL	CARDIAC	ARREST	(OHCA)	IN	MALANG
Authors: Wati Suis Galischa , Wihastuti Titin Andri , Nasution Tina Handayani
Published: January 2019

The incident of Out of Hospital Cardiac Arrest (OHCA) increased every year. One of effort to enhance survival rate due to the incident is by increasing the number of bystander CPR. Besides of a good knowledge and skill about CPR, the tendency of someone for willing or unwilling to behave as a bystander CPR is strongly influenced by their behavioral intention. The aims of this research was to analyze various factors that influence behavioral intention of nursing students to become a bystander CPR. This was a cross-sectional study with proportional sampling tecnique. As a sample of this study were 108 students from various nursing institution in Malang. Multivariat analysis with logistic regression was used to identify the most dominant factor which influencing behavioral intention. Logistic regression showed the following result: age p=0,341, OR=1,683; gender p=0,022, OR=3,113; CPR experience=0,327, OR=1,808 and knowledge: p=0,007, OR=3,101. The result of this study conclude that knowledge about CPR is the most dominant predictor factor in influencing behavioral intention.
Around 1000 BC. Absolute dates for the Final Bronze Age – Early Iron Age transition in Italy: wiggle-match 14C dating of two tree-trunk coffins from Celano
Authors: Plicht J. Van der , Nijboer A.J.
Published: January 2019

At Celano (Abruzzo region, Italy), rare tumulus tombs of the Final Bronze Age were excavated, yielding waterlogged coffins of oak wood. Two tombs were dated by Wiggle-Match Dating (WMD), using the conventional 14C method. This shows that the tumuli were erected around 1030 BC, while the associated artefacts in the sarcophagi are attributable to the final stages of the Bronze Age (FBA) in Italy. Fibulae similar to those found in both tombs at Celano are recovered in modest numbers all over the Italian peninsula and even in Croatia and nearby regions (Glogović 2003; von Merhart 1969, pls. 4, 5, 7). Our date of ca. 1030 BC for the last stages of the Bronze Age in Italy has consequences for the beginning of the Iron Age, which should start around 1000-950 BC, an assessment that is consistent with other radiocarbon sequences obtained for Italy, such as the sequence for Latium Vetus and elsewhere in the western Mediterranean.
Mapping of Islamic Bank Financial Distress in Indonesia
Authors: Iqbal Muhammad , Riyadi Selamet , Sabrianti Priska , Afidah Afifah Nur
Published: January 2019

Abstract: Mapping of Islamic Bank Financial Distress in Indonesia. This study aims to identify and analyse the level of financial distress of Indonesian Islamic Bank.  The data of this study would be utilised to map the level of financial distress of various Islamic banks. This study also aims to assess the level of financial distress by utilising different methods and compare the result. This study measures the level of financial distress by using three different methods, which are: Altman Modification method, Bankometer and Risk Based Bank Rating. This study uses a comparative descriptive approach with eleven samples of Islamic Commercial Banks in Indonesia during 2010-2016. This study finds that Islamic banks in Indonesia are not indicated to have financial distress, but still have the potential to experience financial distress, where each Islamic Bank has different levels of financial distress with another. The three methods of measuring the level of financial distress have differences in measuring financial difficulties in Islamic banks. Keywords: Islamic bank, financial distress, altman modification, bankometerAbstrak: Pemetaan Tingkat Kesulitan Keuangan Bank Syariah di Indonesia. Penelitian ini bertujuan melihat seberapa besar tingkat kesulitan keuangan yang terjadi pada bank syariah di Indonesia. Data penelitian ini ditujukan untuk memetakan keberagaman tingkat kesulitan keuangan bank syariah serta mencoba membandingkan beberapa metode penilaian kesulitan keuangan bank yang ada pada bank syariah. Pengukuran tingkat kesulitan keuangan menggunakan tiga metode yang berbeda, yaitu: metode Altman Modifikasi, Bankometer dan Risk Based Bank Rating. Metode penelitian menggunakan pendekatan deskriptif komparatif dengan sampel sebelas Bank Umum Syariah di Indonesia selama periode 2010-2016. Hasil penelitian menunjukkan bahwa bank syariah di Indonesia tidak terindikasi mengalami kesulitan keuangan, namun tetap berpotensi mengalami kesulitan keuangan dengan tingkat kesulitan keuangan yang berbeda antara satu bank syariah dengan bank syariah lainnya. Penelitian ini juga menemukan bahwa ketiga metode pengukuran tingkat kesulitan keuangan yang digunakan pada penelitian ini memberikan hasil yang berbeda dalam mengukur kesulitan keuangan pada bank syariah. Kata kunci: Bank Syariah, Kesulitan Keuangan, Altman Modifikasi, Bankometer
Effect of External Factors of Technology Acceptance Model Toward Technology Acceptance of Online Travel Agent
Authors: Waluyani Risma Candra , Subroto Bambang , Purnomosidhi Bambang
Published: January 2019

Abstract: Effect of External Factors of Technology Acceptance Model Toward Technology Acceptance of Online Travel Agent. This study aimed to identify and analyse internal factors and external factors which affect the intention of Universitas Brawijaya students to use online travel agent service. Samples were selected by using nonprobability sampling technique and convenience sampling method. The instrument of this study was online questionaires whose result were analyzed by SEM-PLS. This study found that personal innovativeness and self-efficacy affected how students perceive that online travel agent service is easy to use and it is useful for them. Student’s perception, trust in online travel agent service, and information obtained from others affected students’ attitude to use online travel agent service. Furthermore, students who feels that online travel agent technology is useful for them will have positive attitude on the existence of online travel agent service and they wil also have intention to use the online travel agent service. Keywords: Online travel agent, behavioral intention, internal factors, external factors.Abstrak: Pengaruh Faktor Eksternal Technology Acceptance Model Terhadap Penerimaan Teknologi Online Travel Agent. Tujuan penelitian ini adalah untuk menguji faktor internal dan faktor eksternal yang mempengaruhi minat mahasiswa Universitas Brawijaya untuk menggunakan agen perjalanan online. Sampel penelitian dipilih menggunakan teknik nonprobability sampling dengan metode convenience sampling. Instrumen penelitian ini adalah kuesioner yang dibuat secara online dengan bantuan google form dan dianalisis dengan SEM-PLS. Hasil penelitian ini menunjukkan bahwa inovasi pribadi dan keyakinan sendiri mepengaruhi persepsi mahasiswa bahwa teknologi agen perjalanan online mudah digunakan, yang selanjutnya membuat mereka berpendapat bahwa teknologi agen perjalanan online berguna bagi mahasiswa. Persepsi mahasiswa bahwa teknologi agen perjalanan online berguna bagi mereka, kepercayaan terhadap teknologi agen perjalanan online, dan informasi yang diperoleh dari orang lain melalui internet mempengaruhi sikap mahasiswa untuk menggunakan teknologi agen perjalanan online. Selanjutnya mahasiswa yang berpendapat bahwa teknologi agen perjalanan online berguna bagi mereka akan bersikap positif atas adanya teknologi agen perjalanan online dan berminat untuk menggunakan teknologi agen perjalanan online. Kata kunci: agen perjalanan online, minat perilaku, faktor internal, faktor eksternal.
Treatment of Atopic Dermatitis Using a Full-Body Blue Light Device (AD-Blue): Protocol of a Randomized Controlled Trial (Preprint)
Authors: Kromer Christian , Nühnen Viktoria P , Pfützner Wolfgang , Pfeiffer Sebastian , Laubach Hans-Joachim , Boehncke Wolf-Henning , Liebmann Joerg , Born Matthias , Schön Michael P , Buhl Timo
Published: January 2019

BACKGROUND

Irradiation with visible blue light (wavelength 400-495 nm) is a promising, effective, and safe new treatment option for chronic inflammatory skin diseases such as psoriasis and atopic dermatitis.

OBJECTIVE

We will perform a multicenter, placebo-controlled, double-blinded, 3-armed, prospective, randomized controlled trial to investigate the efficacy and safety of full-body blue light devices (wavelengths: 415 nm and 450 nm) compared with that of placebo irradiation for the treatment of atopic dermatitis.

METHODS

We are planning to enroll a total of 150 patients at the University hospitals in Göttingen (Germany), Marburg (Germany), and Geneva (Switzerland).

RESULTS

The trial was approved by the lead ethics committee of the medical faculty of the University of Göttingen (21/11/16). Further approvals were obtained from local and federal authorities (ethics committee Marburg, Cantonal Commission for Research Ethics Geneva, Suisse Medic, and Bundesinstitut für Arzneimittel und Medizinprodukte).

CONCLUSIONS

We will disseminate the results in a peer-reviewed journal.

CLINICALTRIAL

ClinicalTrials.gov NCT03085303; https://clinicaltrials.gov/ct2/show/NCT03085303 (Archived by WebCite at http://www.webcitation.org/73ucqkkA1)

INTERNATIONAL REGISTERED REPOR

PRR1-10.2196/11911
Program “Mindful Parenting” untuk Meningkatkan Kesejahteraan Subjektif Ibu yang Memiliki Anak Retardasi Mental
Authors: Rinaldi Martaria Rizky , Retnowati Sofia
Published: January 2019

Parenting child with intellectual disability is associated with physical and psychological problems that influence mother’s subjective well-being. The evidence is show that mindfulness based intervention can increase of life satisfaction, elicit positive affect, dan minimize negative affect, so that it can increase subjective well-being. The aim of this study is to examine the effectiveness of “Mindful parenting” program in increasing subjective well-being mother who has child with intellectual disability. This study uses a one-group pretest-posttesttt design using a double pretest. “Mindful Parenting” program was administered to ten mothers of children with intellectual disability. Participant attend 8 sessions of “Mindful parenting” program in four meeting. Analysis using Friedman test showed significance result (Fr(2) = 11.13, p< 0.05). It conclude that there was significant effect of “Mindful parenting” program on promotes subjective well-being of mothers of children with intellectual disability.
Digital Interpretability of Annual Tile-based Mosaic of Landsat-8 OLI for Time-series Land Cover Analysis in the Central Part of Sumatra
Authors: Dimyati Ratih Dewanti , Danoedoro Projo , Hartono Hartono , Kustiyo Kustiyo , Dimyati Muhammad
Published: January 2019

This paper presents an interoperability of annual tile-based mosaic (MTB) images, as well as a verification of the validity of the model for the time series land cover analysis purposes. The primary data used are MTB image of Landsat-8 of the central part of Sumatra, acquired from January 2015 to June 2017. The method used for the interoperability validation is the digital analysis of three-years time series land cover. The classification was performed with four band spectral groups. Training samples are taken from the image of 2016. The results are then reclassified to improve the overall accuracy score based on Jefferies Matusita (JM) distance. The interoperability can be measured by the average of overall accuracy (AOA) score, namely Good (scores > 80%), Fair (70.0% -79.9%), and Bad (< 70%). The results show that the use of the groups Bands 6-5-4-3-2 performs the consistent accuracy level of Good with an AOA score of 86% for six classes object. Whereas the use of the groups Bands 6-5-4-3-2, Bands 6-5-4, and Bands 6-5 shows the consistent accuracy level of Good up to four classes object with an AOA score of 89%, 82%, and 81%, respectively. It means that the annual mosaic image of MTB model is accepted for the image interoperability with an AOA score of > 80% for six and four classes object. Thus the most efficient for interoperability is the use of Bands 6-5 to analyze four class object of land cover.
Participatory implementation within climate change related policies in urbanized area of Indonesia
Authors: Suarma Utia , Hizbaron Dyah Rahmawati , Sudibyakto Sudibyakto , Nurjani Emilya
Published: January 2019

Geographically, Indonesia has been subjected towards various climate change related phenomena. This research aim at evaluation of participatory implementation towards climate change related policy which has been set in Indonesia. The research method derived from qualitative framework developed by UNESCO. The research took RAN-API or National Action Plan upon Climate Change Adaptation which has been established since 2013. The document has been integrated within National Medium Term Plan launched at 2015 up to 2019. The research revealed that participation has been inclusive to many stakeholder involved within climate change adaptation program. Furthermore, encouragement needs to be carried out at all level especially in urbanized area. Local to national government has pivotal role to introduce many activities engaged to climate change adaptation. At different array, the research also revealed that many participation has been initiated independently by non-government organization as well as local stakeholder which need to be documented in order to ensure its merits.
Comparative and combined effectiveness of innovative therapies in cancer: a literature review
Authors: Geldof Tine , Rawal Smita , Dyck Walter Van , Huys Isabelle
Published: January 2019

To achieve therapeutic innovation in oncology, already expensive novel medicines are often concomitantly combined to potentially enhance effectiveness. While this aggravates the pricing problem, comparing effectiveness of novel yet expensive (concomitant) treatments is much needed for healthcare decision-making to deliver effective but affordable treatments. This study reviewed published clinical trials and real-world studies of targeted and immune therapies. In total, 48 studies compared and/or combined multiple novel products on breast, colorectal, lung and melanoma cancers. To a great extent, products evaluated in each study were owned by one manufacturer. However, cross-manufacturer assessments are also needed. Next to costs and intensive market competition, the absence of a regulatory framework enforcing real-world multiproduct studies prevents these from being conducted. Trusted third parties could facilitate such real-world studies, for which appropriate and efficient data access is needed.
JOGA PEDRA NA GENI: UMA DISCUSSÃO PARA ALÉM DOS TERRITÓRIOS URBANOS DE SOCIABILIDADES GAYS NA CIDADE DE SALVADOR-BA
Authors: Meira Celio Silva , Ferreira Lucas Aguiar Tomaz
Published: January 2019

O artigo, aqui apresentado, objetivou discutir sobre os territórios de identidades relacionados às minorias sexuais dentro dos espaços urbanos. Tomamos como referência o debate sobre território e o percurso histórico da luta pela visibilidade das manifestações de membros da comunidade de Lésbicas, Gays, Bissexuais, Travestis, Transexuais, Transgêneros, Queer e Intersexis-LGBTQI+. Fazendo uma correlação da música Geni e o Zepelim de Chico Buarque com as violências que esses sujeitos sociais sofrem, e o porquê dos mesmos procurem espaços específicos de socialização. A partir desta perspectiva, trouxemos algumas discussões do campo empírico aqui analisado, a cidade de Salvador – Bahia e seus territórios de “liberdade” para as minorias que expressam orientações sexuais diferentes do padrão heteronormativo.
INFLUÊNCIA DA ATIVIDADE MINERADORA NA DINÂMICA DA PAISAGEM: REFLEXÕES TEÓRICAS
Authors: Matos Manara Teles Santos , Maia Meirilane Rodrigues
Published: January 2019

O presente artigo tem como objetivo discutir a dinâmica da paisagem minerada em Vitória da Conquista-BA. Cuja discussão foi desenvolvida a partir de reflexões teóricas acerca do espaço, paisagem e natureza sob a perspectiva socioambiental. Os seguintes autores foram utilizados como aporte teórico para o desenvolvimento desse trabalho: Bertrand (1972), Sotchava (1963), Cosgrove (2002), Santos (1988) e Smith (1988). Nesse sentido, a paisagem é processo resultante da relação sociedade-natureza, pois é marcada pelos processos físicos, sociais e históricos que a fizeram existir. A mineração envolve processos naturais, econômicos, políticos e sociais; é permeada de diversos interesses por conta dos diferentes sujeitos sociais enredados, os quais terão percepções diversificadas acerca dos aspectos positivos e/ou negativos ocasionados pela exploração de bens minerais, o que influencia diretamente na dinâmica da paisagem. A visão excludente da relação sociedade-natureza, a coloca como fonte de recursos para sociedade a fim de atender suas demandas.