bluuebunny/crossref_metadata_2025 huggingface dataset:
Popularização das práticas Integrativas e Complementares em Saúde
Authors: Agnolin Júlia Sonáglio , Hoffmann Gabriela , Barretta Jeana Cristina , Lutinski Junir Antônio
Published: August 2022

As Práticas Integrativas e Complementares em Saúde (PICS) representam um conjunto de sistemas terapêuticos que utilizam tecnologias que visam à prevenção de agravos e a recuperação da saúde. Essas práticas contribuem na redução dos gastos públicos e do uso dos serviços do Sistema Único de Saúde. Diante da relevância das PICS, este estudo teve como objetivo caracterizar a percepção e o uso das PICS pelos residentes do Sul do Brasil. Trata-se de um estudo observacional e transversal realizado por meio da aplicação de um questionário com perguntas semiestruturadas acerca do perfil sociodemográfico dos indivíduos e aspectos que abrangem o uso das PICS no Sul do Brasil. Foram utilizadas estatísticas descritivas de frequência para descrever os resultados. Também foi utilizado o teste Chi-quadrado para testar possíveis associações entre variáveis. O estudo contou com 213 participantes, sendo a maioria do sexo feminino e com entre 18 e 25 anos. A maioria dos participantes reconhece os benefícios na utilização das PICS, contudo, não têm o hábito de utilizá-las. Destaca-se a relevância da divulgação das PICS junto à população, assim como os seus benefícios encorajando à sua utilização e a promoção da saúde.
Morfogênese e rendimento forrageiro da aveia branca (Avena sativa) sob fontes e níveis de fósforo
Authors: Pereira Luan Carlos de Almeida , Dias Juliano Cesar , Bittencourt Henrique von Hertwig
Published: August 2022

Objetivou-se avaliar a morfologia e o rendimento forrageiro da aveia branca cultivada sob diferentes doses e fontes de adubação fosfatada. O delineamento experimental utilizado foi o inteiramente casualizado em um esquema fatorial 4x2, com cinco repetições. Os tratamentos foram quatro doses de fósforo: 0, 35, 70 e 140 kg ha-1 de P2O5, e duas fontes de fósforo: superfosfato simples (18% de P2O5) e fosfato natural reativo (33% de P2O5). Observou-se efeito (p<0,05) da adubação fosfatada na produção de matéria seca (MS), com a aplicação de 140 kg ha-1 de P2O5 da fonte superfosfato simples apresentando o maior rendimento forrageiro. A produção de MS em função da adubação fosfatada por superfosfato simples foi ajustada por análise de regressão ao modelo quadrático (Y = 1,091 + 0,0055*X + 9,537e-0,5*X², p = 0,0253, R² = 0,99), sugerindo que quanto mais fósforo for disponibilizado a planta maior será sua taxa de acúmulo de MS. A produção de MS em função da adubação fosfatada com fosfato natural foi ajustada ao modelo linear (Y = 0,00413*X + 1,107, p = 0,0127, R² = 0,97), sugerindo aumento constante na produção de MS com aumento na disponibilidade de P2O5 para a aveia branca. O superfosfato simples foi a fonte de fósforo de maior eficiência, garantindo maior produção de matéria seca das plantas de aveia. Independente da fonte de fósforo, não se atingiu o ponto de inflexão da produção forrageira da aveia branca com até 140 kg ha-1 de P2O5.
Atenção das equipes de saúde diante pacientes em estado crítico
Authors: Souza Lizandra Ellem Silva de , Mendonça Vinícius Rodrigues , Silva Marcelo Lima da , Oliveira Gerson Pedroso de , Silva Thayná Vasconcelos da , Silva Alexandro do Vale , Abreu Adriana Corrêa de , Brangioni Marina Stancoloviche Veiga , Bitu Nivea Tainá Ramos , Silva Enila Barreto Carvalho da
Published: August 2022

Pacientes críticos são aqueles que se encontram com patologias que agravam seu estado de saúde trazendo a necessidade de um cuidado continuo e complexo para a melhora do seu quadro.  Com isso as equipes de saúde estão responsáveis pelo cuidado a esses indivíduos. Estudo tem como objetivo identificar o papel das equipes de saúde na prestação de serviços a pacientes em estado crítico. Trata-se de uma revisão de literatura com uma abordagem qualitativa. As bases de dados utilizadas para busca foram Scielo e Lilacs com uso dos descritores da saúde pacientes críticos AND equipe de saúde. Ocorreu nos meses de maio e junho de 2022. Os critérios de inclusão foram estudos publicados nos últimos 5 anos entre 2018 e 2022, nacionais e internacionais, com o idioma português ou em outros desde que tradução disponível para língua portuguesa. Os critérios de exclusão foram: estudos duplicados nas bases de dados, sem relevaria para o presente estudo e disponíveis apenas com pagamento. Também foram excluídas teses, trabalhos de conclusão de curso e resumos. As equipes de saúde estão totalmente ligadas ao cuidado com pacientes em estado crítico, estão responsáveis pela garantia da oferta de todos os meios que contribuam para sua melhora. O papel desses profissionais é em conjunto e deve ser discutido procurando a resolução das necessidades encontradas de cada pessoa em estado crítico.
Amitriptyline: Useful for the prophylactic treatment of migraine?
Authors: Santos Pereira Cristian dos , Farias Joelson Rodrigues , Machado Paulo Roberto Peres , Braga Glenda Luciana Costa , Corôa Maria Cláudia Pinheiro , Ribeiro Rafaela Marques , Damasceno Taissa Viana , Picanço Maria Rosinete Siqueira , Tiago Allan Carlos da Silva , Varela Everton Luiz Pompeu
Published: August 2022

Migraine is a type of headache described by recurrent attacks that may be accompanied by some symptoms, such as nausea, vomiting, phonophobia, among other conditions. About 1 billion people in the world could come into existence. Some measurements are recognized for the treatment of use, as measurements are made appropriately with cost drugs. Amitriptyline has become a great alternative for the prophylactic treatment of migraine, its metabolization is extensively in the liver and its analgesic effect is linked to the ability to modulate mood or modulate the excitability of neurons that transmit pain signals from the dura mater. This study is an integrative literature review. A search key was created, and the search was performed in the Web of Science (WoS-all databases). A temporal search was carried out between the years 2018 to June 2022, without language restriction. Tools such as MapChart were used to create the worldwide distribution map based on the corresponding author. 100 articles were rescued from the Web of Science, of which only 20 were chosen to compose the final table, due to their high relevance and sensitivity in the investigated topic. Migraine prevention for patients is critical, as it can reduce stigma and enhance quality of life.
Infertilidade masculina: principais causas e terapêuticas emergentes, uma revisão
Authors: Marconato Tauana Caroline , Donne Ricardo Ditzel Delle , Romano Renata Marino , Romano Marco Aurelio
Published: August 2022

O conceito de infertilidade e seus fatores predisponentes estão ainda em processo de descobrimento. Nos dias atuais, sabe-se que a maior parte dos casos de infertilidade está ligado ao homem e que sua rotina e hábitos de vida tem relevante importância nesse aspecto. O enfoque central foi para o estresse oxidativo, que decorre de atividades como consumo de álcool, tabaco e outras exposições ambientais, afetando diretamente a fertilidade por interferir, por exemplo, na produção hormônios e no próprio processo de espermatogênese. Foram analisados, após aplicação dos critérios de seleção, 48 artigos relacionados à infertilidade masculina, seus desencadeantes, entre eles o estresse oxidativo, bem como mecanismos terapêuticos sendo desenvolvidos para tal, tendo como base as plataformas SciELO e PubMed. Foi evidenciada a influência de fatores como hábitos de vida, alimentação e obesidade, além do fator genético, na etiologia da infertilidade. Dentre as medidas curativas, particularizam-se discussões sobre os estudos genéticos em células tronco como também no âmbito da medicina natural, ainda em desenvolvimento e por vezes negligenciada, juntamente com suplementos antioxidantes. Após um maior conhecimento sobre a efetividade de tais intervenções, conclui-se a relevância e necessidade de investimentos em tais estratégias, visando uma melhor qualidade de vida aos casais que desejam constituir um núcleo familiar e também diretamente aos homens que são, não raramente, estigmatizados pela condição de infertilidade. A presente revisão tem por finalidade descrever as principais causas de infertilidade masculina, com ênfase no estresse oxidativo, bem como das intervenções sendo desenvolvidas e que apresentam eficácia no seu tratamento.
PENYULUHAN PENTINGNYA PERILAKU HIDUP BERSIH DAN SEHAT DENGAN MENINGKATKAN ASUPAN GIZI SEIMBANG PADA MASA PANDEMI
Authors: Putri Rika Indriani Rukmana , Sa’diyah Kholifatus , Mukmila Aniswatul , Widyaningrum Diyah Ayu
Published: August 2022

The community in the village of Ringinasri Sumbermanjing wetan has not fully implemented the Clean and Healthy Lifestyle (PHBS) during the COVID-19 pandemic. This can be seen in students at MA-Al Hisi who have not implemented health protocols and have not paid attention to balanced nutrition as a daily nutritional intake. The solution to overcome this problem is through counseling with the theme of the importance of clean and healthy living behavior during the pandemic. The research procedure includes preliminary, core and final activities. The research instrument used a questionnaire. The results of the questionnaire show that most of the students have understood about clean and healthy living behavior after being given counseling.
Plant extracellular vesicles and their potential in human health research, the practical approach
Authors: KOCHOLATA M , MALY J , MARTINEC J , AUER MALINSKA H
Published: August 2022

Extracellular vesicles are small membrane particles (30-1000 nm) released by Bacteria, Eukaryotes and Archaea. They have been shown to play an important role in intracellular and intercellular communication, within and between kingdoms via transport of bioactive molecules. Thus, they can be involved in altering gene expression and regulation of physiological and pathological processes of the recipient. Their unique properties make extracellular vesicles a perfect candidate vector for targeted drug delivery or a biomarker. For a long time, animal and mainly mammal extracellular vesicles have been used in research. But for plants, there had been speculations about the existence of nanovesicles due to the presence of a cell wall. Today, awareness of plant extracellular vesicles is on the rise and their research has proved they have various functions, such as protein secretion, transport of bioactive molecules or defense against pathogens. Further potential of plant extracellular vesicles is stressed in this review.
THE EFFECT OF SPIRITUAL EMOTIONAL FREEDOM TECHNIQUE (SEFT) THERAPY METHODS ON CHANGES IN ADOLESCENT SMOKING BEHAVIOR
Authors: Winarti Rahayu , Nurkhastana Indar , Rohana Nana
Published: August 2022

Smoking behavior in adolescents is a difficult behavior to change. In cigarettes there are addictive ingredients that make dependence on the wearer. The phenomenon obtained in Bendungan Village, there are 42 teenagers aged 15-19 years who have smoking behavior due to invitations from friends, curiosity, often seeing parents smoking and the desire of teenagers themselves. The Spiritual Emotional Freedom Technique (SEFT) method by tapping 2 fingers on 18 key points in the body's 12 energy pathways. The purpose of this study was to determine the effect of the SEFT therapy method on changes in smoking behavior in adolescents in Bendungan Village, Pabelan District, Semarang Regency.

The research design used is a quantitative method using a pre-experimental type with a one group pretest-posttest design. The sampling technique used 30 respondents. The research instrument is a questionnaire that has been tested for validity in research (Anggraeni, 2019) with the title "Peer Peer Relationships with Smoking Behavior in Early Adolescents" the number of respondents in this assessment is 15 people with an r value of 0.518 provided that the value of r product moment > r table (0.514), then it is declared valid. The analytical method used is Paired Sample T-test.

The results showed that smoking behavior before SEFT therapy was in the moderate category (86.7%) than after being given SEFT therapy in the good category (63.3%). The results of the analysis with the Paired Sample T-test test obtained p value = 0.000 means p value
ANALYSIS OF THE DOTS STRATEGYIMPLEMENTATION DURING COVID-19
Authors: Mellania Violita , Zainafree Intan
Published: August 2022

Tuberculosis is a disease caused by the bacterium Mycobacterium tuberculosis that attacks the lungs and other organs. The target for case finding until August is 176 cases, but the Bulu Lor Health Center has only reached 38 case finding with 21 positive cases. The purpose of the study was to find out how to implement the DOTS strategy policy during the COVID-19 in the work area of the Bulu Lor Health Center Semarang. The study uses a qualitative with determination uses purposive sampling technique with all 18 informants. The results showed that communication on the DOTS strategy during the pandemic used electronic media. There have perception problems when communicating. Human resources and funding are fulfilled, but there are candidates who have resigned. DOTS rooms during the COVID-19 pandemic combine with COVID-19 services. The commitment has been fulfilled, except for the commitment cadres who resigned and patients who dropped out of treatment due to drug side effects. The organizational structure of the DOTS strategy refers to the Regulation of the Minister of Health Number 67 of 2016, but the sputum examination doesn't comply with regulations.

Keyword: Tuberculosis, DOTS Strategy, COVID-19, Policy Implementation, Bulu Lor Primary Health Care
The Comparison of Mungbean (vigna radiata L.) Cultivars in the Presence of Various Potassium Applications
Authors: Ali Umed , Shar Tahmina , Jatoi Ghulam Hussain , Shah Syed Mushtaq Ahmed , Shah Liaqat , Ahmed Irfan , Qambrani Jahansher , Bhutto Mahpara Khatoon , Haskheli Naeema Khatoon
Published: August 2022

Potassium (K) comes under a category of major plant nutrients and is essentially required for plant to complete its life cycle. It is involved in promoting the growth yield and quality of most crops. There are confusions regarding applying accurate potassium dose and investigating the performance of two mungbean cultivars under potassium applications, an experimental trial was laid down at the research area of Pulse Research Sub-Station, Tandojam to determine the performance of two mungbean (AEM-96 and C-23) cultivars in the presence of five potassium applications i.e., 00, 20, 30, 40, and 50 kg K ha-1. The outcomes from the study showed that each trait was significantly improved by increasing the applications of potassium. A significant (P≤0.05) improvement in the growth parameters (Plant height and branches per plant), yield attributes (pods per plant, seeds per pod, seed weight per plant and 1000-seed weight) and yield traits (seed yield and biological yield) was observed in both cultivars under the application of 50 kg K ha-1.  While both cultivars showed similar lower performance in accordance with control (00 kg K ha-1) plots. From cultivars, AEM-96 produced best results as compared to C-23 for each trait on each potassium level. In this regard, mungbean cultivar AEM-96 with 50 kg K ha-1 was recommended for cultivation to obtain good growth and yield performance.
Characterization of Batik Industrial Wastewater in Bogor City
Authors: Kholisoh Siti , Wulandari Intan , Iryani Ani , Sutanto Sutanto , Warnasih Siti
Published: August 2022

Wastewater from the batik industry in Bogor City is the most waste produced from the dyeing process. The batik industry produces waste with concentrated color due to the high concentration of color content from the dyeing process. This affects water bodies as a direct disposal site for waste. Batik waste also has the potential to contain heavy metal compounds derived from the composition of dyes. This will have an impact on the disruption of the balance in the environment around the industry. Therefore, it is necessary to characterize batik wastewater to determine the pollutant content. This research aims to characterize the batik industry wastewater in the city of Bogor by measuring the levels of COD, BOD, TSS, pH, temperature, total chromium content, total phenol content, and sulfide content according to the parameters P.16/MENLKH/SETJEN /KUM.1/4/2019. The results showed the characteristics of the wastewater from the batik industry in Bogor City with levels of COD in dyeing waste at 797 mg/L and total waste at 52463 mg/L, BOD levels in dyeing waste at 431 mg/L, and total waste at 238 mg/L. TSS in the dyeing waste is 706.5 mg/L and the total waste is 3679 mg/L, the temperature in the dyeing waste is 26.9 °C and the total waste is 26.3°C, pH in staining waste at 1.62 and total waste at 6.82; the total chromium content in the staining waste was 2.62 mg/L and the total waste was 940.2 mg/L, the total phenol content and sulfide content in the dyeing waste and total waste was not detected. The characteristics of batik waste are not by the established quality standards, so there is a need for processing before the waste is discharged into the environment.
Development of A Hybrid Method by Integrating Electrocoagulation Countinous System with Activated Charcoal Adsorption to Treat Sago Wastewater
Authors: Puspitasari Amelia , Sutanto Sutanto , Kusumawadani Linda Jati
Published: August 2022

Wastewater from the sago industry can pose a risk of pollution because it contains chemicals such as high organic matter content, fiber, 4% unextracted starch, nitrogen solution, and cyanoglucoside which are difficult to degrade in the environment. Sago wastewater is generally acidic, has foul smells, and has a high solids concentration. In this study, a hybrid method using electrocoagulation continuous system and activated carbon adsorption was developed to decrease organic and inorganic contaminates which considered importand environmental concern. These two methods have the advantages of simple equipment, easy operation, low efficiency, and short reaction time. The flow rate will affect the pause time of the sample in the reactor. The longer the pause time, feeding will lead to an increase in the level of turbidity that can be lowered. Industrial wastewater variations in the initial analysis then carried out the electrocoagulation process in a continuous system with a container capacity of 1680 mL with an electrode distance of 2 cm, a voltage of 18 volts, and wastewater into a container with a flow rate of 1 mL/, 2 mL/second, 3 mL/ sec, 4 mL/sec, and 5 mL/sec. In addition, the waste is directly into a container containing charcoal. The parameters studied were COD, BOD, TSS, TDS, KMnO4, DO, pH, DHL, and Al concentration analysis with Atomic Absorption Spectrophotometer, odor, and color analysis. The maximum removal efficiency for TDS, TSS. COD, BOD, TDS, KMnO4 were 81.16%, 87.58%, 91.32%, 48.66%, 99.07%, for a flow rate of 1 mL/second, also other parameters also met have met the quality standards set by PerMenLH No. 5.
Can Satellite Mega-Constellations Justify their Impact on Astronomy?
Authors: Petchetti Sai Charan
Published: August 2022

Private space companies are increasingly commercializing near-earth space. Some estimates show that more than 100,000 satellites may orbit the Earth by 2030. This increase in the number of satellites has many consequences for science, particularly astronomy. Satellite mega-constellations for satellite Internet connectivity are one of the main drivers behind the explosion in the number of satellites. Here, we briefly note whether such satellite mega-constellations can justify their impact on astronomy.
Computational and Numerical Methods for Combinatorial Geometric Series and its Applications
Authors: Annamalai Chinnaraji
Published: August 2022

The growing complexity of mathematical and computational modelling demands the simplicity of mathematical and computational equations for solving today’s scientific problems and challenges. This paper presents combinatorial geometric series, innovative binomial coefficients, combinatorial equations, binomial expansions, calculus with combinatorial geometric series, and innovative binomial theorems. Combinatorics involves integers, factorials, binomial coefficients, discrete mathematics, and theoretical computer science for finding solutions to the problems in computing and engineering science. The combinatorial geometric series with binomial expansions and its theorems refer to the methodological advances which are useful for researchers who are working in computational science. Computational science is a rapidly growing multi-and inter-disciplinary area where science, engineering, computation, mathematics, and collaboration use advance computing capabilities to understand and solve the most complex real life problems.
Estrategias de afrontamiento en pacientes con cáncer
Authors: Cruz Lucero Verónica Cristina , Echeverría Villacreses Wilson Oswaldo
Published: August 2022

Introducción: El diagnóstico de cáncer genera una inestabilidad emocional y en muchos casos esto imposibilita un afrontamiento adecuado. El afrontamiento es el esfuerzo cognitivo y conductual constantemente cambiantes que se desarrollan para manejar las demandas específicas como el diangóstico oncológico. El objetivo de la presente investigación fue identificar las estrategias de afrontamiento en un grupo de pacientes con cáncer, en un Hospital de referencia nacional.

Metodología: Este estudio transversal, se realizó en el Hospital Eugenio Espejo de Quito, Ecuador, período enero a  junio del 2018, con una muestra no probabilística, de pacientes con neoplasias, se registraron variables demográficas, clínicas, y el test de afrontamiento de 40 preguntas CSI “El inventario de estrategias de afrontamiento (CSI). Se utiliza estadística descriptiva univariada.y bivariada.

Resultados: Se analizan 47 casos, 74% mujeres, de edad promedio 55 años. De instrucción secundaria completa en el 38 % de los casos. Las Estrategias de Afrontamiento que se presentaron en el 70% de los pacientes fueron: Reestructuración Cognitiva (REC) y Evitación de problemas (EVP), en el 15% se presentó "Resolución de problemas" (REP). Las Estrategias de Afrontamiento en hombres fueron REP con el 57%, mientras que la Expresión Emocional (EEM) se presentó en mujeres en el 86%. En los primeros 6 meses el 77% usa la EEM; de 7 a 12 meses el 19% a la estrategia de Autocrítica (AUC); de 1 a 2 años con un 17% estrategia de Pensamiento Desiderativo (PSD); de 3 o más años con un 14% corresponde a Resolución de Problemas (REP).

Conclusión: Las estrategias de afrontamiento se utilizan en gran proporción en los primeros 6 meses del diagnóstico del cáncer, luego de lo cual las estrategias disminuyen por debajo del 20%.
Ekonomisk hjälp från Svenska kyrkan
Authors: Leo Sandberg Elinn , Panican Alexandru
Published: August 2022

Förändringar i det svenska välfärdssamhället har devalverat ersättningsnivåer för ekonomiskt bistånd. Mottagare av ekonomiskt bistånd söker även ekonomisk hjälp från Svenska kyrkan. Diakonerna arbetar med ekonomisk hjälp, trots att kyrkan saknar nationella riktlinjer för hur och till vem hjälpen förmedlas. Forskningen om kyrkans hjälpverksamhet är sparsmakad, och det finns ingen forskning utifrån brukarperspektiv, en kunskapsbrist som artikeln avser att minska. Empirin bygger på intervjuer med nio personer som tar emot ekonomiskt bistånd och som dessutom söker ekonomisk hjälp från kyrkan. I fokus är anledningar att söka ekonomisk hjälp samt brukarnas framställning av interaktionen med diakonerna. Intervjupersonerna uppger tre skäl till att brukarna vänder sig till kyrkan: (i) försämrat stöd från socialtjänsten, (ii) lättillgängligt ansökningsförfarande hos kyrkan och (iii) möjlighet att dölja den ekonomiska hjälpen för socialtjänsten. Interaktionen med diakonerna präglas enligt brukarna av en stark samhörighet mellan dem och diakonerna. Brukarna använder oväntat en instrumentell logik i interaktionen med diakonerna för att få ansökan beviljad, samtidigt som de kritiserar myndigheterna för samma logik. Detta benämns den instrumentella paradoxen i artikeln.
Invention Foundation of Russia: New Opportunities for Activating the Corporate Venture Capital Market
Authors: Ishchenko Anton , Fedoseev Roman
Published: August 2022

Introduction. The article justifies the need and feasibility of creating a special-purpose vehicle for managing both public intellectual property and industrial property of private rights holders. Methods. The article provides analysis of global practices. Results and Discussion. It is proposed to create the Invention Foundation of Russia in the form of a joint-stock company, with 100 % of the shares belonging to the Russian Federation at the first stage. The key functions of the foundation shall be the formation of patent pools in the most promising areas of technology; support for technology transfer; popularization of intellectual property and promotion of IP literacy; attraction of Russian and foreign investors and industrial partners. Growth of capitalization, number of transactions with intellectual property in foreign markets; increase in dividend flow in the Russian Federation are proposed as key performance indicators of the foundation. Conclusion. According to the author's assessment of the economic effect of creating the Invention Foundation of Russia, in combination with other activities, it will be able to provide the GDP growth of 1 %, and increase the non-resource exports by USD 15 billion per year and the science funding from extrabudgetary sources by 100 %.
Nanocellulose Composites as Smart Devices With Chassis, Light-Directed DNA Storage, Engineered Electronic Properties, and Chip Integration
Authors: Bencurova Elena , Shityakov Sergey , Schaack Dominik , Kaltdorf Martin , Sarukhanyan Edita , Hilgarth Alexander , Rath Christin , Montenegro Sergio , Roth Günter , Lopez Daniel , Dandekar Thomas
Published: August 2022

The rapid development of green and sustainable materials opens up new possibilities in the field of applied research. Such materials include nanocellulose composites that can integrate many components into composites and provide a good chassis for smart devices. In our study, we evaluate four approaches for turning a nanocellulose composite into an information storage or processing device: 1) nanocellulose can be a suitable carrier material and protect information stored in DNA. 2) Nucleotide-processing enzymes (polymerase and exonuclease) can be controlled by light after fusing them with light-gating domains; nucleotide substrate specificity can be changed by mutation or pH change (read-in and read-out of the information). 3) Semiconductors and electronic capabilities can be achieved: we show that nanocellulose is rendered electronic by iodine treatment replacing silicon including microstructures. Nanocellulose semiconductor properties are measured, and the resulting potential including single-electron transistors (SET) and their properties are modeled. Electric current can also be transported by DNA through G-quadruplex DNA molecules; these as well as classical silicon semiconductors can easily be integrated into the nanocellulose composite. 4) To elaborate upon miniaturization and integration for a smart nanocellulose chip device, we demonstrate pH-sensitive dyes in nanocellulose, nanopore creation, and kinase micropatterning on bacterial membranes as well as digital PCR micro-wells. Future application potential includes nano-3D printing and fast molecular processors (e.g., SETs) integrated with DNA storage and conventional electronics. This would also lead to environment-friendly nanocellulose chips for information processing as well as smart nanocellulose composites for biomedical applications and nano-factories.
A Systematic Review of Fall Risk Factors in Stroke Survivors: Towards Improved Assessment Platforms and Protocols
Authors: Abdollahi Masoud , Whitton Natalie , Zand Ramin , Dombovy Mary , Parnianpour Mohamad , Khalaf Kinda , Rashedi Ehsan
Published: August 2022

Background/Purpose: To prevent falling, a common incident with debilitating health consequences among stroke survivors, it is important to identify significant fall risk factors (FRFs) towards developing and implementing predictive and preventive strategies and guidelines. This review provides a systematic approach for identifying the relevant FRFs and shedding light on future directions of research.

Methods: A systematic search was conducted in 5 popular research databases. Studies investigating the FRFs in the stroke community were evaluated to identify the commonality and trend of FRFs in the relevant literature.

Results: twenty-seven relevant articles were reviewed and analyzed spanning the years 1995–2020. The results confirmed that the most common FRFs were age (21/27, i.e., considered in 21 out of 27 studies), gender (21/27), motion-related measures (19/27), motor function/impairment (17/27), balance-related measures (16/27), and cognitive impairment (11/27). Among these factors, motion-related measures had the highest rate of significance (i.e., 84% or 16/19). Due to the high commonality of balance/motion-related measures, we further analyzed these factors. We identified a trend reflecting that subjective tools are increasingly being replaced by simple objective measures (e.g., 10-m walk), and most recently by quantitative measures based on detailed motion analysis.

Conclusion: There remains a gap for a standardized systematic approach for selecting relevant FRFs in stroke fall risk literature. This study provides an evidence-based methodology to identify the relevant risk factors, as well as their commonalities and trends. Three significant areas for future research on post stroke fall risk assessment have been identified: 1) further exploration the efficacy of quantitative detailed motion analysis; 2) implementation of inertial measurement units as a cost-effective and accessible tool in clinics and beyond; and 3) investigation of the capability of cognitive-motor dual-task paradigms and their association with FRFs.
Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold
Authors: Al-Bishari Abdullrahman M. , Al-Shaaobi Bilal A. , Al-Bishari Aisha A. , Al-Baadani Mohammed A. , Yu Liang , Shen Jiating , Cai Lei , Shen Yiding , Deng Zhennan , Gao Peng
Published: August 2022

The accelerating bone healing process is still a major challenge in clinical orthopedics, especially in critical-sized bone defects. Recently, Nanofiber membranes are showing increasing attention in the biomedical field due to their good biocompatibility, mechanical stability, and the ability to work as a drug carrier to achieve localized and sustained drug delivery. Herein, a multifunction nanofiber membrane loaded with vitamin D (Vit D) and curcumin (Cur) was successfully fabricated using electrospinning technology. In addition, we innovatively modified Vit D with PEG to improve the hydrophilicity of PCL nanofibers. The vitro results of CCK-8, alkaline phosphatase (ALP) and mineralization demonstrated that the PCL/Vit D-Cur membrane had great potential for enhancing the proliferation/differentiation of osteoblasts. Moreover, the synergistic effect of Vit D-Cur loaded PCL nanofiber membrane showed a superior ability to improve the anti-inflammatory activity through M2 polarization. Furthermore, in vivo results confirmed that the defect treated with PCL/Vit D-Cur nanofiber membrane was filled with the newly formed bone after 1 month. These results indicate that the Vit D/Cur loaded membrane can be applied for potential bone regeneration therapy.
Biosynthetic approaches to efficient assimilation of CO2via photorespiration modification in plant chassis
Authors: Wang Qing , Yang Hao , Cao Peijian , Chen Fangjian , Zhao Lei
Published: August 2022

Plant chassis has emerged as the platform with great potential for bioproduction of high value-added products such as recombinant protein, vaccine and natural product. However, as the primary metabolic pathway, photorespiration results in the loss of photosynthetically fixed carbon compounds and limits the exploration of plant chassis. People are endeavored to reduce the photorespiration energy or carbon loss based on variation screening or genetic engineering. Insomuch as protein engineering of Rubisco has not resulted in the significant improvement of Rubisco specificity which is linked to the direct CO2 fixation, the biosynthetic approaches of photorespiration bypass are gaining much more attention and manifested great potentiality in conferring efficient assimilation of CO2 in plant chassis. In this review, we summarize the recent studies on the metabolic pathway design and implementation of photorespiration alternative pathway aiming to provide clues to efficiently enhance carbon fixation via the modification of photorespiration in plant chassis for bioproduction. These will benefit the development of plant synthetic metabolism for biorefineries via improvement of artificial carbon sequestration cycle, particularly for the mitigation of serious challenges such as extreme climate change, food and energy shortages in the future.
A reagentless electrochemical immunosensor for sensitive detection of carcinoembryonic antigen based on the interface with redox probe-modified electron transfer wires and effectively immobilized antibody
Authors: Zhang Jing , Yang Luoxing , Pei Jie , Tian Yanzhang , Liu Jiyang
Published: August 2022

Convenient and sensitive detection of tumors marked in serum samples is of great significance for the early diagnosis of cancers. Facile fabrication of reagentless electrochemical immunosensor with efficient sensing interface and high sensitivity is still a challenge. Herein, an electrochemical immunosensor was easily fabricated based on the easy fabrication of immunoassay interface with electron transfer wires, confined redox probes, and conveniently immobilized antibodies, which can achieve sensitive and reagentless determination of the tumor marker, carcinoembryonic antigen (CEA). Carboxyl multi-walled carbon nanotubes (MWCNTs) were firstly modified with an electrochemical redox probe, methylene blue (MB), which has redox potentials distinguished from those of redox molecules commonly existing in biological samples (for example, ascorbic acid and uric acid). After the as-prepared MB-modified MWCNT (MWCNT-MB) was coated on the supporting glassy carbon electrode (GCE), the MWCNT-MB/GCE exhibited improved active area and electron transfer property. Polydopamine (PDA) was then in situ synthesized through simple self-polymerization of dopamine, which acts as the bio-linker to covalently immobilize the anti-CEA antibody (Ab). The developed immunosensor could be applied for electrochemical detection of CEA based on the decrease in the redox signal of MB after specific binding of CEA and immobilized Ab. The fabricated immunosensor can achieve sensitive determination of CEA ranging from 10 pg/ml to 100 ng/ml with a limit of detection (LOD) of 0.6 pg/ml. Determination of CEA in human serum samples was also realized with high accuracy.
Assessment of Storm Floods in a Small Tropical Andean Basins
Authors: Zambrano Nájera Jeannette , Rey Diana Marcela
Published: August 2022

The increase in urbanization processes has considerably changed urban flows, as basin impermeabilization generates increased surface runoff volumes. This induces storm floods that simultaneously generate mobility problems, infrastructure damage, and in extreme conditions, pedestrian deaths. This problem has been widely studied. For small basins with steep watersheds, however, there is little literature to be found. In these basins, the problem is even more complex, as flows are faster and more energized, given the surface slopes, which generates further problems, including drainage infrastructure damage, landslides, and fallen trees. Many solutions have been proposed, which include Sustainable Urban Drainage Systems (SUDS), which work together with the drainage network. These were studied in the present investigation, via the modeling of a basin with those characteristics typical of mountains, using SWMM's Low Impact Development LID model. It was found that rain barrels and green roofs were viable solutions, independently, although the application of additional techniques, such as cisterns and bioretention cells, is also indispensable. The present study also concludes that, although the techniques studied are implemented on a small scale, these should be both planned and implemented by municipal authorities.
Pacific Equatorial Undercurrent: Mean state, sources, and future changes across models
Authors: Stellema Annette , Sen Gupta Alex , Taschetto Andréa S. , Feng Ming
Published: August 2022

The Equatorial Undercurrent (EUC) stretches across the Pacific, transporting cool waters rich in oxygen and nutrients eastward to one of the most productive regions in the ocean. As an intricate part of the global climate system, EUC dynamics are essential to understanding future climate change but are poorly represented in global coupled climate models. This study examines EUC representation and future changes in the latest generations of the Coupled Model Intercomparison Project (CMIP6 and CMIP5) and an eddy-permitting ocean model. We also examine historical and projected changes in EUC source waters, including the Mindanao Current (MC), New Guinea Coastal Undercurrent (NGCU), and interior thermocline convergence. The circulation features in the models are broadly consistent with observations and ocean reanalyses, but improvements from CMIP5 to CMIP6 are limited. In the future projections, the EUC is enhanced in the western Pacific, with less prominent changes in CMIP6, but more so in the eddy-permitting model. The western Pacific EUC enhancement is likely associated with a wind-driven redirection of waters south of the equator, in which the NGCU boundary flow increases while the interior thermocline convergence decreases. This is superimposed on an overall weakening of the North Pacific subtropical overturning cell, including the MC, interior thermocline convergence, and Ekman divergence. As EUC heat and nutrient composition is linked to its sources, these projected changes have implications for the EUC's role in air–sea feedbacks, nutrient replenishment, and oxygen minimum zone ventilation in the eastern Pacific.
Potential ferroptosis key genes in calcific aortic valve disease
Authors: Li Xiong-Zhi , Xiong Zhuo-Chao , Zhang Shao-Ling , Hao Qing-Yun , Gao Ming , Wang Jing-Feng , Gao Jing-Wei , Liu Pin-Ming
Published: August 2022

Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodeling, culminating in aortic stenosis, heart failure, and ultimately premature death. Ferroptosis has been hypothesized to contribute to the pathogenesis of CAVD. We aimed to study the association between ferroptosis genes and CAVD and reveal the potential roles of ferroptosis in CAVD. CAVD-related differentially expressed genes (DEGs) were identified via bioinformatic analysis of Datasets GSE51472 and GSE12644 obtained from Gene Expression Omnibus. A ferroptosis dataset containing 259 genes was obtained from the Ferroptosis Database. We then intersected with CAVD-related DEGs to identify the ferroptosis DEGs. Subsequently, protein–protein interaction networks and functional enrichment analyses were performed for ferroptosis DEGs. Then, we used miRWalk3.0 to predict the target pivotal microRNAs. An in vitro model of CAVD was constructed using human aortic valve interstitial cells. The qRT-PCR and western blotting methods were used to validate the ferroptosis DEGs identified by the microarray data. A total of 21 ferroptosis DEGs in CAVD containing 12 upregulated and nine downregulated genes were identified. The results of the Gene Set Enrichment Analysis (GSEA) and analysis of the KEGG pathway by WebGestalt indicated that the ferroptosis DEGs were enriched in six signaling pathways among which NAFLD (including IL-6, BID, and PRKAA2 genes) and HIF-1 (including IL-6, HIF-1, and HMOX1 genes) signaling pathways were also verified by DAVID and/or Metascape. Finally, the in vitro results showed that the mRNA and protein expression levels of IL-6, HIF-1α, HMOX1, and BID were higher, while the levels of PRKAA2 were lower in the Pi-treated group than those in the control group. However, the addition of ferrostatin-1 (a selective ferroptosis inhibitor) significantly reversed the above changes. Therefore, IL-6, HIF-1α, HMOX1, BID, and PRKAA2 are potential key genes closely associated with ferroptosis in CAVD. Further work is required to explore the underlying ferroptosis-related molecular mechanisms and provide possible therapeutic targets for CAVD.
Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model
Authors: Soto-Navarrete María Teresa , Pozo-Vilumbrales Bárbara , López-Unzu Miguel Ángel , Rueda-Martínez Carmen , Fernández M. Carmen , Durán Ana Carmen , Pavón-Morón Francisco Javier , Rodríguez-Capitán Jorge , Fernández Borja
Published: August 2022

Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. Although different molecular players and etiological factors (genetic and hemodynamic) have been suggested to be involved in aortopathy predisposition and progression, clear etiophysiopathological mechanisms of disease are still missing. The isogenic (genetically uniform) hamster (T) strain shows 40% incidence of BAV, but aortic dilatations have not been detected in this model. We have performed comparative anatomical, histological and molecular analyses of the ascending aorta of animals with tricuspid aortic valve (TAV) and BAV from the T strain (TTAV and TBAV, respectively) and with TAV from a control strain (HTAV). Aortic diameter, smooth muscle apoptosis, elastic waviness, and Tgf-β and Fbn-2 expression were significantly increased in T strain animals, regardless of the valve morphology. Strain and aortic valve morphology did not affect Mmp-9 expression, whereas Mmp-2 transcripts were reduced in BAV animals. eNOS protein amount decreased in both TBAV and TTAV compared to HTAV animals. Thus, histomorphological and molecular alterations of the ascending aorta appear in a genetically uniform spontaneous hamster model irrespective of the aortic valve morphology. This is a direct experimental evidence supporting the genetic association between BAV and aortic dilatation. This model may represent a population of patients with predisposition to BAV aortopathy, in which increased expression of Tgf-β and Fbn-2 alters elastic lamellae structure and induces cell apoptosis mediated by eNOS. Patients either with TAV or BAV with the same genetic defect may show the same risk to develop bicuspid aortopathy.
Micro-Scale Pore-Throat Heterogeneity of Tight Oil Sandstone Reservoirs and Its Influence on Fluid Occurrence State
Authors: Guo Qing , Dong Mancang , Mao Hengbo , Ju Jiangtao
Published: August 2022

Quantitatively characterizing the micro-scale heterogeneity of pore throats in tight sandstone reservoirs is the key to accurately describing the influence of pore structures on fluid occurrence characteristics. In this study, taking the Chang 6 Member of the Yanchang Formation in the Huaqing area of the Ordos Basin as an example, the pore-throat heterogeneity of tight sandstone reservoirs and its influence on the fluid occurrence state have been systematically studied using cast thin section, scanning electron microscope, X-ray diffraction, constant velocity mercury intrusion, and nuclear magnetic resonance tests. The main types of pores developed in the target layer were intergranular pores, followed by feldspar dissolution pores. The radius distribution of the intergranular pores is between 5.0 and 210 μm, with an average value of 50.27 μm. In addition, the pore combination types with the best petrophysical properties are the intergranular pore type, the intergranular-dissolution pore type, and the dissolution-intergranular pore type; the average permeability and porosity are 0.62 mD, 0.40 mD, 0.44 mD, and 12.0, 12.3, 12.3%, respectively. The target sandstones contain four typical T2 relaxation time types. The large-pore-fine-throat combination reservoir has the best petrophysical properties. The larger the pore-throat uniformity value, the more uniform the pore-throat radius, and the greater the reservoir permeability. Therefore, the uniformity of throat development controls the seepage capacity of the tight reservoirs. The movable fluid saturation of different pore types has obvious differences. The movable fluid saturations at the 0.1 and 0.5 μm pore diameters of the macro-pore-fine-throat and macro-pore-micro-throat reservoirs both show an obvious inflection point, and the movable water saturation is higher with a larger throat radius.
Higher order neural processing with input-adaptive dynamic weights on MoS2 memtransistor crossbars
Authors: Rahimifard Leila , Shylendra Ahish , Nasrin Shamma , Liu Stephanie E. , Sangwan Vinod K. , Hersam Mark C. , Trivedi Amit Ranjan
Published: August 2022

The increasing complexity of deep learning systems has pushed conventional computing technologies to their limits. While the memristor is one of the prevailing technologies for deep learning acceleration, it is only suited for classical learning layers where only two operands, namely weights and inputs, are processed simultaneously. Meanwhile, to improve the computational efficiency of deep learning for emerging applications, a variety of non-traditional layers requiring concurrent processing of many operands are becoming popular. For example, hypernetworks improve their predictive robustness by simultaneously processing weights and inputs against the application context. Two-electrode memristor grids cannot directly map emerging layers’ higher-order multiplicative neural interactions. Addressing this unmet need, we present crossbar processing using dual-gated memtransistors based on two-dimensional semiconductor MoS2. Unlike the memristor, the resistance states of memtransistors can be persistently programmed and can be actively controlled by multiple gate electrodes. Thus, the discussed memtransistor crossbar enables several advanced inference architectures beyond a conventional passive crossbar. For example, we show that sneak paths can be effectively suppressed in memtransistor crossbars, whereas they limit size scalability in a passive memristor crossbar. Similarly, exploiting gate terminals to suppress crossbar weights dynamically reduces biasing power by ∼20% in memtransistor crossbars for a fully connected layer of AlexNet. On emerging layers such as hypernetworks, collocating multiple operations within the same crossbar cells reduces operating power by ∼15× on the considered network cases.