bluuebunny/crossref_metadata_2025 huggingface dataset:
Atomistic electronic structure in the single-chain limit of organic conductors
Authors: Craco L. , Carara S. S.
Published: March 2021

Using density functional dynamical mean-field theory we show how electronic interactions can tune a dispersive band structure such that it develops atomistic Landau-Fermi liquidness. Thereby, we show how a relaxed single chain with electron densities slightly below half filling can improve orbital selectivity with coexisting metallic and semiconducting states. Our setup provides a well-controlled environment at the atomistic scale to understand the principles behind orbital-selective electronic reconstruction and the interplay between electron interactions and local electron-hole doping in the single-chain limit of organic conductors.
“The Blackness of Darkness”
Authors: Cohen Lara Langer
Published: March 2021

This article considers Kentucky’s Mammoth Cave as an unexpected site for nineteenth-century theorizations of racialized Blackness. Mammoth Cave became a major tourist attraction in the 1840s, generating a host of guidebooks, travel accounts, magazine illustrations, panoramas, newspaper articles, and fiction. Crucial to its fame was the fact that the guides who led visitors through the cave were enslaved men. This article argues that white writers responded to the guides’ knowledge of the cave by reframing it as affinity. In doing so, they transformed Mammoth Cave’s subterranean darkness into a manifestation of racialized Blackness. But the writers’ racialization of Mammoth Cave also had a tendency to slip out of their control. As they associated its spatial darkness with racialized Blackness, the literal underground of Mammoth Cave flickered into an underground that was more than literal—a mysterious Black formation, of unguessed dimensions and certain danger, beneath the world as they knew it. Finally, the article asks what we can glean from the literature of Mammoth Cave about the body of Black thought it sought to disavow: the alternative relations between race and the underground that the guides theorized through their own subterranean explorations.
Η πρώτη οκταετία διακυβέρνησης Καραμανλή (1955-1963)
Authors: Λουτσίδης Γεώργιος
Published: March 2021

Η παρούσα διδακτορική διατριβή επιχειρεί να εντοπίσει και να αναλύσει τα αίτια που οδήγησαν στην πτώση της Κυβέρνησης της ΕΡΕ το 1958 και στην παραίτηση του Κωνσταντίνου Καραμανλή το 1963. Η μελέτη αυτή προτείνει ένα νέο ερμηνευτικό σχήμα μέσα από το οποίο αναδεικνύονται οι αντιφάσεις ανάμεσα στα κέντρα εξουσίας της περιόδου, όπως στα Ανάκτορα, στους Αμερικανούς και στην κυβέρνηση. Εντός αυτού του ερμηνευτικού σχήματος επιχειρείται να οριστούν τα όρια που είχε το Καραμανλικό κέντρο εξουσίας να αρθρώσει μια αυτοδύναμη πολιτική, ξεφεύγοντας έτσι από τα στενά όρια προσεγγίσεων που θεωρούν τον Καραμανλή ως έναν απλό εντολοδόχο των Ανακτόρων. Παράλληλα έγινε μια προσπάθεια ιστορικής ανασύνθεσης των σημαντικότερων γεγονότων της περιόδου 1955-1963, καθώς αυτό θεωρήθηκε απαραίτητο για την κατανόηση του πολύπλοκου πολιτικού σκηνικού της Μετεμφυλιακής Ελλάδας. Η διατριβή χωρίζεται σε τρία μέρη, με βάση την χρονική περίοδο διακυβέρνησης των τριών κυβερνήσεων της ΕΡΕ. Ιδιαίτερη έμφαση δίνεται στις πολιτικές διεργασίες που προηγήθηκαν της πτώσης της κυβέρνησης Καραμανλή το 1958 και της παραίτησης του 1963. Εξετάζεται η στάση των κομμάτων της αντιπολίτευσης, καθώς και ο ρόλος που διαδραμάτισαν μια σειρά θεσμικών και εξωθεσμικών παραγόντων στην διαμόρφωση των εξελίξεων. Παράλληλα, αναλύονται τα μείζονα θέματα εξωτερικής πολιτικής της περιόδου, όπως το Κυπριακό και η πορεία σύνδεσης της Ελλάδας με την ΕΟΚ, καθώς και οι διεθνείς σχέσεις της χώρας στο πλαίσιο του Ψυχρού Πολέμου. Διερευνώνται οι όροι υπό τους οποίους ο Καραμανλής και οι συνεργάτες του επέλεξαν να χαράξουν μια ευέλικτη και ρεαλιστική εξωτερική πολιτική, που υπερέβαινε το μέχρι τότε σχήμα εξάρτησης της Ελλάδας από τις ΗΠΑ, χωρίς παράλληλα να τίθεται σε αμφισβήτηση ο δυτικός προσανατολισμός της Ελληνικής εξωτερικής πολιτικής.
Η συμβολή των μεγάλων μη-κωδικών (long non-coding) RNAs στην αιτιοπαθογένεια των ΙΦΝΕ
Authors: Ζαχαροπούλου Ειρήνη
Published: March 2021

Ένας αυξανόμενος αριθμός μελετών ευρέως γονιδιώματος (Genome Wide Association Studies, GWAS) έχει αναδείξει εκατοντάδες πολυμορφισμούς που σχετίζονται με τον κίνδυνο εκδήλωσης ιδιοπαθών φλεγμονωδών νόσων του εντέρου (ΙΦΝΕ), όπως η νόσος Crohn (NC) και η ελκώδης κολίτιδα (ΕΚ). Πρόσφατα, έχει δειχθεί ότι τα μεγάλα μη-κωδικά RNA μετάγραφα (large non-coding RNA transcripts, LncRNAs) διαδραματίζουν ρυθμιστικό ρόλο σε ποικίλα νοσήματα, μεταβάλλοντας το επίπεδο έκφρασης των γονιδίων προκαλώντας εναλλακτικό μάτισμα ή επιδρώντας στη δευτεροταγή δομή τους, συμπεριλαμβανομένων των ΙΦΝΕ. Ωστόσο, η παθογένεση των ΙΦΝΕ παραμένει έως σήμερα ασαφής και υπάρχουν περιορισμένα δεδομένα σχετικά με το ρόλο των lncRNAs σε αυτές τις παθήσεις. Επομένως, στόχος της παρούσας μελέτης είναι να εκτιμήσει τη συσχέτιση μεταξύ πολυμορφισμών σε lncRNA γονίδια και την εκδήλωση ΙΦΝΕ στον ελληνικό πληθυσμό και να συμβάλει στην αποσαφήνιση της παθοφυσιολογίας των ΙΦΝΕ. Πραγματοποιήθηκε μελέτη πληθυσμού ασθενώνμαρτύρων και γονοτύπηση των πολυμορφισμών μονού νουκλεοτιδίου (single nucleotide polymorphisms, SNPs) rs1476514, rs3757247 και rs597325 σε δείγμα ορού αίματος από 242 ασθενείς με NC, 185 ασθενείς με ΕΚ και 220 υγιείς μάρτυρες.Βρέθηκε ότι η συχνότητα του αλληλόμορφου Α του SNP rs1476514 επικρατή στον υγιή πληθυσμό. Επιπροσθέτως, σχετικά με τον SNP rs3757247, η συχνότητα του αλληλόμορφου G είναι υψηλότερη στους υγιείς μάρτυρες σε σύγκριση με του ασθενείς με ΕΚ ενώ σε όλα τα υπό μελέτη δείγματα διαπιστώθηκε ετεροζυγωτία για τον SNP rs597325. Συμπερασματικά, η κατανόηση των μηχανισμών που συμμετέχουν στην εκδήλωση των ΙΦΝΕ είναι επί του παρόντος περιορισμένη και η αιτιολογία τους παραμένει άγνωστη. Καθώς όμως συσσωρεύονται δεδομένα που υποδεικνύουν ότι υπάρχει συσχέτιση ορισμένων SNPs σε lncRNAs με τις ΙΦΝΕ, θα χρειαστούν μελέτες με μεγαλύτερο πληθυσμό ώστε να επιβεβαιωθούν τα αποτελέσματα και να αναζητηθεί ο ρόλος των απορρυθμισμένων lncRNAs στην παθογένεση των ΙΦΝΕ.
Investigation and management of iron deficiency anaemia in a specialist palliative care setting and the role of intravenous iron: a descriptive analysis of hospice data
Authors: Steele Thomas , Bonwick Helen , Nwosu Amara Callistus , Chapman Laura
Published: March 2021

Background: Anaemia is common in hospice populations and associated with significant symptom burden. Guidelines recommend investigating for and treating iron deficiency (ID), but there is little evidence of this practice in palliative care populations. This report describes the results of investigations for and subsequent management of ID in a UK hospice.

Methods: This is a descriptive study of routine clinical data. Laboratory and clinical records were reviewed retrospectively for 12 months following the implementation, in August 2018, of routine investigation for ID amongst patients with clinically relevant anaemia in whom treatment would be considered. Absolute (AID) and functional iron deficiency (FID) were diagnosed using established definitions and treatments recorded.

Results: Iron status was evaluated in 112 cases, representing 25/110 (22.7%) of those with mild, 46/76 (60.5%) moderate and 41/54 (75.9%) severe anaemia. Twenty-eight (25%) were defined as having AID, 48 (42.8%) FID and 36 (32%) no ID. There was a significant difference between groups in symptoms triggering haemoglobin check and diagnosis, with a higher proportion of patients with classic symptoms of anaemia and gastrointestinal malignancy in those with AID. Intravenous iron was given on 12 occasions in the hospice with no major adverse events. Subjective symptom benefit in 7 cases and a statistically significant increase in overall mean haemoglobin were observed.

Conclusions: This report describes the outcome of investigations for iron deficiency in patients with clinically significant anaemia in a UK hospice. Results indicate iron deficiency is common and can be safely treated with intravenous iron replacement, within current guidelines, in a hospice setting. Further research should define the optimum use of this approach in palliative care patients.
Developing a Minimum Data Set for a congenital abnormalities surveillance programme in Rwanda – a modified e-Delphi consensus study
Authors: Uwineza Annette , Muhorakeye Aline , Hitayezu Janvier , Cartledge Peter Thomas
Published: March 2021

Background: In 2015 it was reported that approximately 300,000 newborns die within four weeks of birth every year, worldwide, due to congenital anomalies.  This represents approximately 11% of neonatal deaths. This has led scientists, clinicians and public health authorities to establish congenital abnormality registries (CARs). There is currently no CAR in Rwanda. In establishing such a registry, it was determined that the first step was to identify the Minimum Data Set (MDS) of items/variables and outcomes for the registry to ensure that the final results are meaningful and employable. This study aimed to use Delphi consensus methods to identify a methodologically robust MDS for a congenital abnormality surveillance programme in Rwanda.

Methods: A three-round, modified Delphi study was undertaken between April and June 2017. Round 1 was a literature and internet search followed by an open and closed question round with experts in Rounds 2 and 3, respectively.

Results: An initial draft MDS of 134 items was created from a review of 15 African studies and 14 international repository tools including the European Surveillance of Congenital Anomalies and the World Health Organization surveillance guidance. In total, 36 and 34 eligible participants were included in Rounds 2 and 3, respectively. A total of 32 new items were added by participants in Round 2. 103 items met the pre-defined consensus criteria and made up the final MDS in Round 3.

Conclusions: This is the first Minimum Data Set for a congenital abnormality surveillance programme in an African nation identified in the literature.  The next stage is to field-test the surveillance programme using passive case-finding in teaching hospitals in Rwanda.
DEVILS: a tool for the visualization of large datasets with a high dynamic range
Authors: Guiet Romain , Burri Olivier , Chiaruttini Nicolas , Hagens Olivier , Seitz Arne
Published: March 2021

The number of grey values that can be displayed on monitors and be processed by the human eye is smaller than the dynamic range of image-based sensors. This makes the visualization of such data a challenge, especially with specimens where small dim structures are equally important as large bright ones, or whenever variations in intensity, such as non-homogeneous staining efficiencies or light depth penetration, becomes an issue.

While simple intensity display mappings are easily possible, these fail to provide a one-shot observation that can display objects of varying intensities. In order to facilitate the visualization-based analysis of large volumetric datasets, we developed an easy-to-use ImageJ plugin enabling the compressed display of features within several magnitudes of intensities. The Display Enhancement for Visual Inspection of Large Stacks plugin (DEVILS) homogenizes the intensities by using a combination of local and global pixel operations to allow for high and low intensities to be visible simultaneously to the human eye.

The plugin is based on a single, intuitively understandable parameter, features a preview mode, and uses parallelization to process multiple image planes. As output, the plugin is capable of producing a BigDataViewer-compatible dataset for fast visualization.

We demonstrate the utility of the plugin for large volumetric image data.
Conversion of natural forests to farmlands and its associated woody species diversity and carbon stocks in a span of 33 years (1984 to 2016): in the case of southwestern Ethiopia
Authors: Kefalew Tamiru , Betemariyam Mulugeta , Tolera Motuma
Published: March 2021

Background:Gura-Ferda forest is one of the Afromontane rainforests in the southwestern region of Ethiopia. However, since 1984, large parts of this forest have become increasingly disturbed and fragmented due to forest conversion into forest farm interface and farmlands. The study was conducted to assess changes of woody species diversity and carbon stock in association with the conversion of natural forest to forest farm interface and farmlands.

Methods:Data were collected from natural forest, forest farm interface and farmland which are historically forest lands before 1984. A total of 90 nested plots (20m×20m for natural forest and forest farm interface; 50m*100m for farmland)) were established for inventory of woody species. Three 1m×1m subplots were established to collect litter and soil samples. A total of 180 soil samples were collected. The total carbon stocks were estimated by summing carbon stock in the biomass and soil (0-60 cm depth).

Results:Results showed that Shannon-Wiener diversity (H’) in forest farm interface (H’ = 1.57) is relatively lower than that of natural forest (H’ = 3.33) but higher than farmland (H’ = 1.42). The total carbon stocks of natural forest were approximately 1.21 and 2.54 times higher than that of forest farm interface and farmland.

Conclusion:Our study revealed that the changes of Natural Forest to Forest Farm Interface and Farmland have effects on the diversity of woody species and carbon stocks.
Case series of the first three severe COVID-19 patients treated with the secretome of hypoxia-mesenchymal stem cells in Indonesia
Authors: Putra Agung , Widyatmoko Agus , Ibrahim Sugeng , Amansyah Fajar , Amansyah Farid , Berlian Mukti Arja , Retnaningsih Retnaningsih , Pasongka Zenitalia , Sari Flora Eka , Rachmad Basuki
Published: March 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of coronavirus disease 2019 (COVID-19), which has been rapidly spreading. Several guideline therapies have been proposed as a possible treatment for SARS-CoV-2, however, these therapies are not sufficient to treat a severe condition of SARS-CoV-2 infection characterised by the increase of D-dimer and C-reactive protein (CRP) levels, and patchy ground-glass opacities (GGOs). Secretome-mesenchymal stem cells (S-MSCs) produced by MSCs under hypoxia could excessively release several anti-inflammatory cytokines and growth factors to control the COVID-19 cytokine storm and accelerate lung injury improvement. This is the first study investigating the clinical outcomes of three severe COVID-19 patients admitted to the intensive care unit of three different hospitals in Indonesia treated with S-MSCs. The decrease of D-dimer and CRP level was reported for all patients treated with S-MSCs. This was in line with improvement of pulmonary radiology, blood gas level, and hematologic assessment. In conclusion, these cases suggest that S-MSCs could effectively control D-dimer, CRP level and GGOs of severe COVID-19 patients associated with recovered pulmonary function.
Reflective practice across speech and language therapy and education: a protocol for an integrative review
Authors: McCluskey Jessica , Gallagher Aoife L. , Murphy Carol-Anne
Published: March 2021

Effective co-practice is considered a linchpin of inclusive education. Speech and language therapists (SLT), in collaboration with teachers, are amongst the professionals who have a role in ensuring inclusion for students. The challenges of collaboration are well documented, with communication considered a potential antidote. Proposals for how collaborative communication can take place often align with models of reflection. Uncertainty around a shared language for reflection within and across the professions of teaching and SLT may pose a barrier to it occurring. Reflection has long been documented as a strategy used by effective clinicians to improve practice. Hence, teachers and SLTs reflecting together could be considered ‘a port of entry’ for effective collaborative practice. This study aims to synthesise literature and knowledge on the phenomenon of reflective practice across the professions to facilitate collaboration for inclusive education.

The method of qualitative evidence synthesis will be an integrative review. A systematic search will be conducted to extract empirical studies, reviews and theoretical papers on the topic of reflection across both professions.  An adapted version of the PRISMA reporting guidelines will be used in the development, design and reporting of this review. Four databases will be searched: CINAHL, SCOPUS, Education Source and ERIC. A web-based search will also be conducted to retrieve relevant policy documents. Included literature will be appraised using the M-MAT and an adapted checklist from the Joanna Briggs Institute. Deductive content analysis will endeavour to determine if a shared language exists about reflection, across the professions of teaching and speech and language therapy.

Establishing a shared language represents a first step towards the development of a framework for collaborative reflection between teachers and SLTs. This is turn serves to inform future research, policy and practice regarding how speech and language therapist can work collaboratively with teachers in schools.
Deprivation of the future: towards the social relevance of depression in post-Soviet authoritarian democracies. The case of Belarus
Authors: Shchyttsova Tatiana
Published: March 2021

The article addresses the question as to whether the transition of post-Soviet societies to capitalist democracy has led to the same kind of depressiveness that has been diagnosed by Western scholars and intellectuals with regard to Western societies. Taking Belarus as an example, I argue that the latest political history and the (g)local economic situation as well as the cultural characteristics of the Eastern European post-Soviet countries form a specific complex of conditions that define affective modes of both social and individual life. Drawing on various empirical materials, the article examines how depression as both an individual and public feeling can be shaped by particular conditions and characteristics of Belarusian society that developed under an authoritarian regime. In order to approach depression as a complex phenomenon that combines individual and social aspects, I suggest the theoretical frame built on a combination of phenomenological and sociocritical perspectives. The article results in clarification of what is the principal difference between the social production of depression in contemporary (neo)liberal democracies and that in Belarusian authoritarian democracy.
Optical-image communication through random-phase propagation channels using phase-shifting coding
Authors: Servin Manuel , Padilla Moises
Published: March 2021

We propose an optical-image communication system robust to random-phase propagation using phase-shifting (PS) image coding. That is, this optical-image communication system is based on digital PS interferometry principles. Each pixel of the parallel transmitted image is coded as the phase of a sequence of

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phase-shifted fringe patterns. The temporal fringe patterns may be displayed on a TV screen (or a multimedia projector) for transmission through the random-phase channel. At the receiver, the PS fringe patterns are digitized with a telescopic digital camera. The received fringes are phase-demodulated using an

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-steps least-squares PS algorithm (LS-PSA). We show that the received, phase-demodulated images are less blurred and have better contrast than any received image without PS coding. We propose and analyze a mathematical model for the received PS fringes degraded by random-phase propagation. This PS communication system can also be used for robust optical communications through random refractive media such as underwater, air–water, or random-thickness textured glass. In particular, we show experiments for LS-PSA imaging through textured-glass, obtaining sharper images. As far as we know, this is the first time that PS interferometry has been used for parallel optical-image communication through random-phase channels.
Spatially resolved self-heating and thermal impedance of laser diodes using CCD-TR imaging
Authors: McKenna Robert , Mickus Dovydas , Naimi Sepideh , Murphy Caolan , McDermott Michael , Corbett Simon , McCloskey David , Donegan John Francis
Published: March 2021

The spatial distribution of the surface temperature of single and multi-section slotted semiconductor laser diodes with surface gratings is investigated experimentally with CCD-thermoreflectance imaging. The lasers are single frequency devices, operating at approximately 1550 nm. High resolution temperature maps of the laser ridge are obtained, with spatial resolution near 1 µm. The temperature profile in the direction lateral to the ridge is presented and a rapid decay in temperature away from the ridge is observed. Acquisition of the temperature maps takes about 8 minutes, with three maps required for a 400 µm device. The ridge temperature rise is shown to be linear with the power consumed by the diode. The temperature profile along the laser ridge is shown to be uniform within a section of the multi-section laser. The thermal impedance of the single section slotted laser and the various sections of the multi-section slotted laser were determined. It was found that the thermal impedance ridge length product (ZthL) was 40 ± 6 ° C µm/mW for all section lengths. Between sections a rapid decay is also observed.
Electrical and optical characteristics of highly transparent MOVPE-grown AlGaN-based tunnel heterojunction LEDs emitting at 232  nm
Authors: Mehnke Frank , Kuhn Christian , Guttmann Martin , Sulmoni Luca , Montag Verena , Glaab Johannes , Wernicke Tim , Kneissl Michael
Published: March 2021

We present the growth and electro-optical characteristics of highly transparent AlGaN-based tunnel heterojunction light-emitting diodes (LEDs) emitting at 232 nm entirely grown by metalorganic vapor phase epitaxy (MOVPE). A GaN:Si interlayer was embedded into a highly Mg- and Si-doped

Al

0.87

Ga

0.13

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tunnel junction to enable polarization field enhanced tunneling. The LEDs exhibit an on-wafer integrated emission power of 77 μW at 5 mA, which correlates to an external quantum efficiency (EQE) of 0.29% with 45 μW emitted through the bottom sapphire substrate and 32 μW emitted through the transparent top surface. After depositing a highly reflective aluminum reflector, a maximum emission power of 1.73 mW was achieved at 100 mA under pulsed mode operation with a maximum EQE of 0.35% as collected through the bottom substrate.
Cloning and functional characterization of seed-specific LEC1A promoter from peanut (Arachis hypogaea L.)
Authors: Tang Guiying , Xu Pingli , Li Pengxiang , Zhu Jieqiong , Chen Guangxia , Shan Lei , Wan Shubo
Published: March 2021

LEAFY COTYLEDON1 (LEC1) is a HAP3 subunit of CCAAT-binding transcription factor, which controls several aspects of embryo and postembryo development, including embryo morphogenesis, storage reserve accumulation and skotomorphogenesis. Herein, using the method of chromosomal walking, a 2707bp upstream sequence from the ATG initiation codon site ofAhLEC1Awhich is a homolog of ArabidopsisLEC1was isolated in peanut. Its transcriptional start site confirmed by 5’ RACE was located at 82 nt from 5’ upstream of ATG. The bioinformatics analysis revealed that there existed many tissue-specific elements and light responsive motifs in its promoter. To identify the functional region of theAhLEC1Apromoter, seven plant expression vectors expressing theGUS(β-glucuronidase) gene, driven by 5’ terminal series deleted fragments ofAhLEC1Apromoter, were constructed and transformed into Arabidopsis. Results of GUS histochemical staining showed that the regulatory region containing 82bp of 5’ UTR and 2228bp promoter could facilitate GUS to express preferentially in the embryos at different development periods of Arabidopsis. Taken together, it was inferred that the expression ofAhLEC1Aduring seed development of peanut might be controlled positively by several seed-specific regulatory elements, as well as negatively by some other regulatory elements inhibiting its expression in other organs. Moreover, theGUSexpression pattern of transgenic seedlings in darkness and in light was relevant to the light-responsive elements scattered inAhLEC1Apromoter segment, implying that these light-responsive elements harbored in theAhLEC1Apromoter regulate skotomorphogenesis of peanut seeds, andAhLEC1Aexpression was inhibited after the germinated seedlings were transferred from darkness to light.
DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in mice
Authors: Prompetchara Eakachai , Ketloy Chutitorn , Tharakhet Kittipan , Kaewpang Papatsara , Buranapraditkun Supranee , Techawiwattanaboon Teerasit , Sathean-anan-kun Suwitra , Pitakpolrat Patrawadee , Watcharaplueksadee Supaporn , Phumiamorn Supaporn , Wijagkanalan Wassana , Patarakul Kanitha , Palaga Tanapat , Ruxrungtham Kiat
Published: March 2021

More than 65 million people have been confirmed infection with SARS-CoV-2 and more than 1 million have died from COVID-19 and this pandemic remains critical worldwide. Effective vaccines are one of the most important strategies to limit the pandemic. Here, we report a construction strategy of DNA vaccine candidates expressing full length wild type SARS-CoV-2 spike (S) protein, S1 or S2 region and their immunogenicity in mice. All DNA vaccine constructs of pCMVkan-S, -S1 and -S2 induced high levels of specific binding IgG that showed a balance of IgG1/IgG2a response. However, only the sera from mice vaccinated with pCMKkan-S or -S1 DNA vaccines could inhibit viral RBD and ACE2 interaction. The highest neutralizing antibody (NAb) titer was found in pCMVkan-S group, followed by -S1, while -S2 showed the lowest PRNT50 titers. The geometric mean titers (GMTs) were 2,551, 1,005 and 291 for pCMVkan-S, -S1 and -S2, respectively. pCMVkan-S construct vaccine also induced the highest magnitude and breadth of T cells response. Analysis of IFN-γ positive cells after stimulation with SARS-CoV-2 spike peptide pools were 2,991, 1,376 and 1,885 SFC/106 splenocytes for pCMVkan-S, -S1 and -S2, respectively. Our findings highlighted that full-length S antigen is more potent than the truncated spike (S1 or S2) in inducing of neutralizing antibody and robust T cell responses.
Cultural landscape as element of spatial negotiations in a small town: The example of Giżycko, Poland
Authors: Bedyński Wojciech
Published: March 2021

We are used to situations where landscapes are decomposing, changing and disappearing – it is a common side-effect of globalization, migrations, weakening of cross-generational transmission, climate change, rapid and chaotic urbanization processes, etc. However, what happens when the physical part of a landscape remains but the people are gone? After the Second World War, there were several places in Europe where the change of population was in total due to mass exterminations and forced migrations of all nations or groups. One of these was Mazury, where the former German population was moved in 1945 and replaced by Polish immigrants from many different areas. The new community had to reintegrate the landscape and put new narrations to places and objects they found on site. Some of the pre-war characters of the region remained despite an almost complete population shift, which may lead to a conclusion that landscapes have an element of their own biography.
A Stakeholders’ Approach of building energy saving projects in Hungary - Sustainability orientation versus cost saving
Authors: Bíró-Szigeti Szilvia , Vágási Mária
Published: March 2021

The paper focuses on projects aimed at energy saving on the residential / housing segment of the building energy / energetic market where SMEs and microenterprises are predominant in Hungary and expect finding individual business opportunities. The first part of this paper refers to the imperatives and indices related to energy consumption and saving. In the second section three models of a stakeholders’s approach are presented regarding their motivations, resources and relations.
A honi állami egyetem mint tudásalkotó szervezet egyes szervezeti tulajdonságai
Authors: Szabó Tibor , Velencei Jolán
Published: March 2021

A szerzők a honi állami egyetem, mint tudásalkotó szervezet egyes szervezeti tulajdonságait mutatják be a Budapesti Műszaki és Gazdaságtudományi Egyetemen megfigyelt szervezetimagatartás-formákat alapul véve. A tanulmányban megvizsgálják, hogy melyek azok a – gyenge erősségű piaci környezetben működő – tudásvállalati szervezeti viselkedési jegyek, melyek leginkább befolyásolják valamely állami egyetem szervezeti tulajdonságait. A vizsgálathoz kiindulásképpen feltételezték, hogy az egyetemek kreatív szervezetek.
A lean management megvalósításának jellegzetes problémái
Authors: Kelemen Tamás
Published: March 2021

A lean menedzsment, vagy ahogyan sokan ismerik: a Toyota Production System olyan módszertant takar, melytől sokan azt remélik, hogy alkalmazása legalább olyan hatékonyságnövelést eredményez, mint amelyekről az esettanulmányokban olvashatunk. Ez a legjobb út a csodaszerré válás felé. A legnagyobb veszélye ennek az, hogy így a menedzsment abba az illúzióba ringatja magát, hogy egy új módszer bevezetése révén megtakarítható a gyötrelmes belső folyamatfejlesztés, és majd a külsős tanácsadók mindent elintéznek. A cikkben a szerző bemutatja egy jól működő lean rendszer feltételeit és a leggyakoribb hibákat, melyeket a döntéshozók elkövetnek.
Válasz a legújabb kihívásokra: projektportfólió-menedzsment
Authors: Sebestyén Zoltán
Published: March 2021

A projektek menedzselése manapság is alapvetően az ötvenes években kialakult koncepciók és technikák segítségével történik. Az elmúlt évtizedek során ezek sokat változtak, csiszolódtak, finomodtak, és az informatika fejlődésével mindenki számára könnyen elérhetővé és alkalmazhatóvá váltak. A projektalapú működés elterjedése és az egy kézben összefutó projektek nagy száma szükségessé tette, hogy megfelelő magasságból tekintsünk projektjeink összességére: megjelent a projektportfólió-menedzsment.
Oktatási minőségparaméterek meghatározása asszociációs módszerekkel
Authors: Bérces Roland , Erdei János
Published: March 2021

Az oktatás minőségbiztosítása során általánosan alkalmazott kérdőíves értékelésekkel kapcsolatban elmondható, hogy azok eredményei nagyon is szubjektív tartalmúak, és sokkal többet jelentenek, semhogy egyszerű statisztikai módszerekkel teljes mértékben fel lehessen őket dolgozni. A direkt tartalom mellett fontos a latens érzelmi, logikai háttér is. A szerzők dolgozatukban egy olyan brainstormingon alapuló módszert ismertetnek, amellyel meghatározhatók a hallgatók számára fontos minőségparaméterek e latens, érzelmi vonatkozásai is. Kimutatták, hogy a „hagyományos osztályzásos” minőségértékelés és a brainstorming-módszer alapján elvégzett értékelés ugyanarra – de más szempontokat figyelembe vevő – eredményre vezet. A két módszer kombinált alkalmazásával pontosabb, teljesebb képet lehet nyerni egy képzés minőségéről.
A karcsú (lean) elvek alkalmazásának tapasztalatai az egészségügyi folyamatok fejlesztésében (Experiences of the adaptation of lean management in the development of healthcare processes)
Authors: Jenei István
Published: March 2021

Az elmúlt néhány évben a külföldi sajtóban és szakmai publikációkban egyre többször jelenik meg a „lean egészségügy”, azaz a karcsú menedzsment alkalmazása az egészségügyben mint téma. Habár az ez irányú kutatások még nemzetközi szinten is csak legfeljebb a hajnalukon tartanak, Magyarországon még szinte teljes a sötétség. Ennek a cikknek az a célja, hogy egyrészről felhívja a kutatók, de még inkább a egészségügyi dolgozók, menedzserek figyelmét erre a menedzsmenteszközre és filozófiára, mely új lehetőségeket kínál, másrészről, hogy áttekintést adjon a területen végzett nemzetközi kutatások eredményeiről. A tanulmány ennek megfelelően alapvetően két részre bontható. Az első felében az egészségügyi szolgáltatások helyzetének rövid jellemzése után a karcsú menedzsment alapjait és az egészségügyi szolgáltatásokban való alkalmazásának eszményét mutatja be. A második fele ugyanakkor 16 esettanulmány elemzésén keresztül bemutatja, hogy meddig jutott a világ a „lean egészségügy” ideájának megvalósításában. _______ In the past few years “Lean Healthcare” – the adaptation of lean management into healthcare settings – turns up as a topic often and often in foreign press and the in the professional publications. Although researches at international level in this field are at best at their dawning, in Hungary the darkness is almost complete. This article aims at one side to draw researchers’ and even more healthcare employees’ and managers’ attention to this management tool and philosophy, which offers new possibilities. From the other side to provide an overview of the results of the researches conducted in this field. Reflecting this doubled aim the study is divided into two major sections. In the first part the situation of the health care providers is shortly described followed by the introduction of the basics of the lean management and the idea of applying it into healthcare services. While the second part of the study shows how far the World reached in realizing the idea of “Lean Healthcare” by analyzing 16 cases.
Dynamic seismic analysis of bridge using response spectrum and time history methods
Authors: Brinissat Marame , Kuti Rajmund , Louhibi Zouhir
Published: March 2021

Dynamic analysis is very important to better understand the performance of structural elements of a bridge. For this purpose, a seismic analysis of an Algerian highway bridge designed with the new Algerian seismic bridge regulation (RPOA -2008) was carried out using linear and nonlinear analyses. Therefore, response spectrum, time history analyses were performed to evaluate the seismic responses of the designed bridge. The performance of the designed bridge is assessed using 10 ground motion records. The proposed methodology allows an efficient comparison of the seismic response of the bridge in terms of base shear forces, bending moment and displacements. Finally, the paper concludes with a discussion of the specific outcomes.
Rice Husk Demineralization: Effect of Washing Solution on Its Physicochemical Structure and Thermal Degradation
Authors: Wijayanti Hesti , Nata Iryanti Fatyasari , Irawan Chairul , Jelita Rinny
Published: March 2021

Generally, biomass consists of various amounts of minerals. These minerals influence the biomass characteristics and behavior during their use in a thermochemical process such as pyrolysis. The conversion during pyrolysis and its final product will be affected. This research was carried out to study the impact of washing treatment in water and acid solutions on the rice husk as the raw material for pyrolysis. Also, the effect of acid strength (citric acid as the weak acid while nitric acid as the strong acid) and its concentration (1, 5, and 10 wt.%) was investigated. The results confirmed from the thermogravimetry (TGA/DTG) analysis, surface analysis (SEM), and spectra (FTIR) analysis describe the treatment using water caused less change on the rice husk surface structure and its thermal degradation. However, it seems hard to reduce the minerals (proved from XRF analysis). Meanwhile, the treatment using acids solution resulted in lower mineral composition than the rice husk without treatment. This result is more visible for demineralization using a 5 wt.% nitric acid solution. However, for a higher concentration (washing treatment using 10 wt.% solutions of nitric acid), the degradation on rice husk structure was more occurred.
Uric Acid Sensor Based on PEDOT:PSS Modified Screen-Printed Carbon Electrode Fabricated with a Simple Painting Technique
Authors: Wahyuni Wulan Tri , Heryanto Rudi , Rohaeti Eti , Fauzi Achmad , Putra Budi Riza
Published: March 2021

A screen-printed carbon electrode is a suitable electrode for electrochemical sensors due to its simplicity and portability. This study aimed to fabricate a screen-printed carbon electrode modified with poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (SPCE-PEDOT:PSS) to improve the electrochemical performance for uric acid detection. The SPCE was fabricated using a layer-by-layer painting process of conductive ink consisting of graphite as a conductive material, polystyrene as a polymeric binder, and dichloromethane solvent on a polyvinyl chloride paper substrate. The fabricated SPCE was then modified with PEDOT:PSS by a drop-casting method. The characterization of SPCE-PEDOT:PSS surface morphology was performed using the scanning electron microscopy technique. The SPCE-PEDOT:PSS provided an acceptable linearity (R2 = 0.9985, 0.9993, 0.9985), sensitivity (0.070, 0.015, 0.024 µA/µM), precision (%RSD = 2.70%, 2.89%, 2.40%), limit of detection (1.61 µM, 1.14 µM, 1.62 µM), and limit of quantitation (5.37 µM, 3.81 µM to 5.39 µM) in measurement of uric acid standard solution using cyclic voltammetry, amperometry, and differential pulse voltammetry techniques, respectively. The studies using SPCE-PEDOT:PSS indicated that the electrode could be applied in the electrochemical measurement of uric acid in the human urine sample.
Alliances between Israel and Other Nations in Light of the Pentateuch’s Prohibitions in the Greek Bible
Authors: Nawrot Janusz
Published: March 2021

The conducted exegesis of some particular verses from the Septuagint indicates that two initial covenants made between a representative of the chosen nation with a Gentile party (Abraham and Solomon) did not breach the obligations resulting from the Law of Moses. The theological portrait of Abraham in the Book of Genesis captures an unambiguous evaluation of his conduct in accordance with the Law although the Law itself appeared considerably later when Moses lived. The pact between Solomon and Hiram deserves a similar evaluation. However, the later covenants between the kings of Israel and Judah with Gentile rulers deserve an extremely negative evaluation. Although they did not formally violate the Mosaic prohibitions, they were evaluated as a violation of trust in the Lord as He was the only Partner of the covenant between Himself and the Israelites. Such an interpretation is possible especially in light of Deut 7:6 which accentuates the uniqueness of Israel as a nation chosen by God from among other nations. And because this selection of Israel was done on the foundation of the covenant made on the Mount Sinai, it should be a one-of-a-kind covenant that should not be replaced with another pact signed with a human being, and let alone a Gentile. In all of the cases above, starting from King Asa and ending with Archpriest Jonathan, there was a true violation of the rule whereby the Lord was the only Partner of the covenant with His people. Thus, each of the analyzed treatises met with valid criticism both from a prophet and the inspired author. It is difficult to treat these violations as a major breach of the faith of Israel because of the established diplomatic relations. However, it was the rule of God’s uniqueness as a foundation for any sphere in the life of the chosen people that was violated. It included the political sphere which should not be excluded from the chosen people’s faith.
The New Moon Festival in the Priestly Calendar of the Pentateuch. Exegesis of Fragments from The Book of Leviticus (Lev. 23:23–25) and The Book of Numbers (Num. 28:11–15; 29:1–6)
Authors: Jędrzejczak Andrzej Łukasz
Published: March 2021

In the present article the author deals with pericopes from the priestly layer in the Pentateuch, which include references concerning the New Moon Festival. In the first point of this article, the author underlines connections of Hebrew words with other Semitics languages in terms of naming this feast. The controversial issue is the translation of Lev. 23:23–25, in which many scholars see not the New Moon Festival, but the New Year Festival. The author sets himself the task, using synchronous methods of work on the biblical text, to present his translation proposal of this disputed fragment. Also, he deals with the problem of the Hebrew expression תְּרוּעָה , which leaves some interpretative freedom as to how to celebrate this festive day. An important point in the presented analysis is an attempt to outline the difficulties associated with placing the examined fragments in one of the layers. However, the author does not intend to solve this issue. In his last point, the author analyzes the fragments mentioned in the title, often juxtaposing them with each other or referring to biblical texts that come from a different layer (Deuteronomist) or extra-biblical testimonies.
Approaching the Bible Through Fables. A Commemoration of the 25th Anniversary of the Publication of The Interpretation of the Bible in the Church
Authors: Dzikiewicz Daniel
Published: March 2021

Nowadays, Catholic exegetes interpret the Bible using a variety of methods and approaches. The most important of these are mentioned in the document entitled The Interpretation of the Bible in the Church. More than 25 years have passed since this act was published. This article wants to commemorate this event. It proposes an approach to the Bible through fables. The application of the proposed approach undoubtedly enriches the interpretation of the Scriptures. This thesis is demonstrated by the application of two fables motifs: fish and laughter. In fables, fish and laughter quite often mark the beginning of a new stage in the life of a certain protagonist or even become the causative agent of pregnancy, i.e. a new life. Paying attention to these ideas enables a better understanding of those biblical texts that also contain themes of fish and laughter.
Polish Catholic Religious Culture in the Post-Tridentine Era
Authors: Kaczor-Scheitler Katarzyna
Published: March 2021

This article presents Catholic religious culture in Poland in post-Tridentine era. It takes into account one of the manifestations of change taking place at the time, namely a dynamic development of male and female religious orders. The article shows the connection between the intensification of religious life and the development of ascetic and mystical theology resulting from the general renewal of Catholic theology. The influence of the Jesuits on the spirituality of female orders as well as their role in introducing the practice of methodical mental prayer is highlighted. The impact of Spanish spirituality on Polish religious life after the Council of Trent is also emphasised, with special attention drawn to Saint Ignatius of Loyola and the Jesuits, Saint John of the Cross and the Discalced Carmelites, Saint Theresa of Ávila and her Discalced Carmelite nuns, Louis of Granada with the Dominicans, and Saint Peter of Alcántara, one of the founders of the Franciscan Friars of the Strict Observance. Polish Catholic religious literature of the post-Tridentine era is also reflected upon, including ascetic and mystical writings adopted from Italian and Spanish religious literature.
An evaluation of permanent crops: Evidence from the “Plant the Future” project, Georgia
Authors: Zivzivadze Lasha , Taktakishvili Tengiz , Zviadadze Ekaterine , Machavariani Giorgi
Published: March 2021

Promoting investments in permanent crops is often considered by the government as a powerful measure to support long-term growth in agriculture. The same attitude is prevalent among agricultural policy makers in Georgia and hence, country’s government and the Ministry of Environmental Protection and Agriculture of Georgia initiate and coordinate projects facilitating new investments in permanent crops. The article deals with an evaluation of an impact of “Plant the Future” project in Georgia that provides funds for the potential beneficiaries for planting permanent crops. The structure and scope of the project are discussed in the article, and the relevant data regarding the area planted, financial impact, and beneficiaries for the period from 2015 to 2019 are analysed and the impact projection is made for the period of 2020–2043. Research showed that the target indicators of the project were fully achieved. In addition, there were a high demand from farmers to participate in this project and as a result, the budget spent in 2017–2019 exceeded the planned budget. The project appears to be beneficial in terms of net present values that are positive for all discussed discount rates, meaning that the benefits of the project are greater than costs. The return on investment of the project is around 10%, which is greater than the basic discount rate (8%). Social impact also seems to be high with 1,350 beneficiaries. According to the projection, from 2015 to 2024, around 3,000 beneficiaries will benefit from this project. In the methodology, five evaluation criteria are used, namely, relevance, effectiveness, efficiency, impact, and sustainability. Based on the evaluation, specific recommendations are given.
Heat exposure and workers’ health: a systematic review
Authors: Lee Junhyeong , Lee Yong Ho , Choi Won-Jun , Ham Seunghon , Kang Seong-Kyu , Yoon Jin-Ha , Yoon Min Joo , Kang Mo-Yeol , Lee Wanhyung
Published: March 2021

Objectives

Several studies on the health effects of heat exposure on workers have been reported; however, only few studies have summarized the overall and systematic health effects of heat exposure on workers. This study aims to review the scientific reports on the health status of workers exposed to high temperatures in the workplace.

Methods

We reviewed literature from databases such as PubMed and Google Scholar, using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines to identify studies that address health effects of heat exposure among workers.

Results

In total, 459 articles were identified, and finally, 47 articles were selected. Various health effects of heat exposure on workers have been reported, such as heat-related diseases, deaths, accidents or injuries, effects on the urinary system, reproductive system, and on the psychological system.

Conclusions

Our review suggests that many workers are vulnerable to heat exposure, and this has a health effect on workers.
The Relationship Between Cognitive Abilities and Trait Clinical Features in Patients With Borderline Personality Disorder
Authors: Belvederi Murri Martino , Folesani Federica , Costa Silvia , Biancosino Bruno , Zerbinati Luigi , Ounalli Heifa , Rossetto Agnese , Caruso Rosangela , Nanni Maria Giulia , Grassi Luigi
Published: March 2021

Very few studies have focused on the relationship between cognitive functions and clinical features in borderline personality disorder (BPD). Subjects with BPD and healthy controls were administered the Repeatable Battery for the Assessment of Neuropsychological Status, Trail Making Test A and B, and the Wisconsin Card Sorting Test. The Brief Symptom Inventory (BSI-53) was used to assess the severity of current symptoms. Attachment style was assessed with the Experiences in Close Relationship Questionnaire, identity integration with the Personality Structure Questionnaire, and other domains of personality dysfunction with the RUDE Scale for Personality Dysfunction. Patients with BPD performed significantly worse than healthy controls in all cognitive domains. Cognitive functions, particularly delayed memory and visuospatial abilities, displayed meaningful associations with trait-like clinical features, above the effect of global cognition and state psychopathology. These findings highlight the need to evaluate effects of cognitive rehabilitation on trait features among individuals with BPD.