bluuebunny/crossref_metadata_2025 huggingface dataset:
Subjectivity as a cultural form of social reality. On the philosophical- theoretical potential of Max Weber’s interpretation of modernity
Authors:   Technical University of Berlin, Adolphi Rainer
Published: October 2023

The paper shows the philosophical content of Max Weber’s contribution to a theory of modernity. Weber adopts the deepest questions of the classical philosophical tradition, adding important dimensions and differentiations to them. The specific nature of modern subjectivity is the achievement of a cultural becoming, and it is far more complex than all contemporary interpretations that consider the modern era to be at its end. — (I) Firstly, we will interpret the well-known (and influential) text The Protestant Ethic and the Spirit of Capitalism (Die protestantische Ethik und der Geist des Kapitalismus, 1904/05), with a special focus on its philosophical-theoretical thoughtelements. That which Weber refers to here philosophically as the “Spirit” of a way of life and of its social forms encompasses the whole of a cultural transformation: a fundamental change in the concept of action, in the conception of the acting subject, in the horizon of the space of action (“world”), and in the understanding of sociality. In this new structure of individuality, subjectivity is connected with “objectiveness” [Sachlichkeit], of all things. Notwithstanding, the essence of all of these fundamental changes cannot be characterized solely through (modern) rationality and rationalization, but is fixed on people equipped with a specific habitual ethos. — (II) In the second part, we aim to develop Weber’s idea further on a general level, from the point of view of present-day debates on subjectivity. To this end, we will discern four systematically decisive issues: (1) One component of modern subjectivity is the “inner” social relatedness; there is always an internal forum where the affiliation to a “we” is confirmed and acknowledged (or rejected). (2) Weber saw the significance of the psychologization of the self (and of others) — of the different cultural images, concepts and explanations of subjectivity. (3) From this perspective, subjectivity (both in thought and in practice) is essentially the history of its interpretations — a process of many legacies and their transformation. (4) Existing social forms are above all sedimented “Spirit”, in connection with impositions of participation and conformity (and of “formation” [Bildung]); the established social reality itself generates specific cultural profiles of subjectivity.
What and how Markus Gabriel proves in his book “I am Not a Brain”
Authors:   Lomonosov Moscow State University, Vasilyev Vadim V.
Published: October 2023

The paper is a discussion of the book by the German philosopher Marcus Gabriel “I am Not a Brain” in the context of the distinction between Analytic and Continental philosophical traditions. Gabriel denies the benefit of such a distinction. However, his book may be a good illustration of the opposite. The paper shows why this is so. The main thing is that when presenting the theoretical positions of certain philosophers, Gabriel is inclined to refer to non-philosophical explanations of their origins. This manner of presentation has nothing to do with the methods of analytic philosophy. Analytic philosophers evaluate philosophical concepts and arguments based on themselves. In addition to clarifying this issue, the paper examines the main ideas of Gabriel’s book and evaluates some of the ideas proposed by him related to the concepts of consciousness, the human spirit and the problem of free will. In particular, the paper discusses a concept that receives the name “neo-existentialism” from Gabriel. His solution to the problem of free will is also considered, which is one of the varieties of compatibilism, the position according to which free will can coexist with causal determinism, which means a state of affairs in which at any given time the world has only one really possible future. The connection of this decision with Gabriel’s more general metaphysical ideas, expressed in his book about the nonexistence of the world, is shown. Special attention is paid to the features of Gabriel’s criticism of alternative approaches to the interpretation of consciousness and free will. The analysis of Gabriel’s particular concepts confirms the general conclusion of this paper that his book is not related to the analytical philosophical tradition.
Prince V. F. Odoevsky in search of “Russian harmony”
Authors:   Lomonosov Moscow State University, Kozyrev Alexey P.
Published: October 2023

The article examines the searching for national identity in the musical and critical heritage of Prince Vladimir Fyodorovich Odoyevsky, which is associated with his philosophical interests and reflects his philosophical development after the “Society of Lyubomudriye” (“Society of Wisdom”) and “Russian nights”. The 19th century is the century of discovery of the national, and the culture and aesthetics of romanticism contributed to that discovery and led to intense nation-building. Odoevsky distinguishes between Russian and the so-called “general” Western European music, basing this distinction on the analysis of Old Russian singing. It is based on the system of Echos (“glas”) and Ecphonesis (“poglasitsa”), which is typologically close to the ancient Indian scales. He studies the “hook letter” (“Kryuki”) reform carried out in the 16th–17th centuries by Ivan Shaidurov and other “didascals”, comparing it with the activities of Guido of Arezzo in the West in the 11th century. Odoevsky perceives music, firstly, as an ordered system of mathematical patterns, that is confirmed by the ideas of Leibniz and Euler, and secondly, as a special spiritual reality associated with ascetic practices. Odoevsky connects the national in music not with an appeal to folk songs, and even less with its recording in the spirit of European harmony, but with a deep form of musical composition, associated with the specificity of musical neuma. Music turns out to be an integral part of the iconosphere, it correlates with architecture and other kinds of art. Odoevsky’s ideas were developed in the works of the contemporary Russian cultural philosopher and composer Vladimir Martynov. The article examines the controversy of Sergei Taneyev and Pyotr Tchaikovsky, in which Taneyev, continuing Odoevsky’s ideas, defends the concept of a special “Russian harmony” and builds his work strategy in accordance with that idea. Tchaikovsky, on the other hand, stands for the unity of the European musical process, although he recognizes the national originality of various musical schools. Tchaikovsky’s statements about the contiguity of the Russian musical tradition with the European tradition were censored in the Soviet publication of Tchaikovsky and Taneyev correspondence (1951).
Axiosphere of sister cities: Is it possible to transmit cultural memory?
Authors:   St. Petersburg State University, Volkova Anna V. , Kulakova Tat’jana A. ,   St. Petersburg State University
Published: October 2023

The article is devoted to understanding the institution of sister cities in the context of the developing international crisis, when urban diplomacy, successful practices of interstate civil cooperation, perceived for decades as unshakable and value-oriented, were subjected to “suspension” or “cancellation”. On the other hand, the territorial changes in 2022, the entry of new territories into Russia and the establishment of twinning relations between Russian cities and the cities of Donbass give the institution of sister cities a new meaning and important political and cultural significance. The formation and development of the axiosphere of twin cities is seen as an important factor in the development of interregional cooperation and the “binding” of Russian territories. The interdisciplinary of this study is expressed in addressing not only issues of public policy, social philosophy, cultural studies, ethics, economics, but also in the desire to take into account the specifics of the developing digital society, while the authors consider regional governance issues from the position of an axiological approach. The working with cultural memory today can act as a resource for building an effective cultural policy in the region, but the construction of new meanings and relationships, images and priorities for future development is no less significant. The authors note the importance of civil initiatives and movements, social media, whose activities are aimed at maintaining the social sphere and creating a digital environment of trust, at intensifying urban, civil cooperation in the network as a counterbalance to the aggressive anti-Russian, Russophobic network practices used today.
Historical-philosophical debates on Plato’s “unwritten doctrines”: Current positions
Authors:   University of Belgrade, Deretić Irina
Published: October 2023

Ever since a new way of reading Plato based on “unwritten doctrines” was articulated, it became a matter of dispute. However, the testimonies of its existence are undeniable. This expression was used by Aristotle in his Physics and its description can be found both in Aristotle and other in the classical thinkers. There are three key points crucial for Plato’s “unwritten doctrines” i. e. his oral lectures held at the Academy. These are: the doctrine about the Principles i. e. the One and the Indeterminate Dyad (hen and aoristos duas), the thesis about the geometrical construction of the world and the doctrine about ideal numbers. These numbers are referred to in both “direct” and “indirect” tradition. The controversy regarding arose in German academic circles where intensive study of Plato has a long and highly developed tradition. In the Anglo-Saxon world this discussion appears not to have been well received and has sometimes even provoked a rejection (especially in the circle of H. Chernis and his followers). However, this certainly does not lead to the conclusion that studies drawing on Plato’s “unwritten doctrines” have not appeared in the English-speaking world, which sought new ways of understanding the meaning of his philosophy. In this paper, first, I will assess the different readings, as well as their arguments regarding the importance of “unwritten doctrines” for accounting for Plato’s philosophy. Then, I will argue for my stance in this debate.
The concept of beauty in Dionisii Karthusian’s treatise “On the Grace of the World and the Beauty of God”
Authors:   Far Eastern Federal University, Fedchuk Dmitry A.
Published: October 2023

The concept of beauty in philosophy received its foundation in scholastic metaphysics. The content of this notion was far from the meaning it would receive in modern aesthetics. Aesthetics connects the intellectual experience of contemplating beauty with sensuality while in medieval natural theology pulchrum was comprehended by way of the cognition of the idea as the radiance of form in matter. In his understanding of beauty Dionisii the Carthusian used the ideas of his predecessors such as Augustine, Alexander of Hales, Thomas Aquinas. He thought beauty as transcendental. But in his interpretation there was a transition from a purely rationalistic explanation of beauty to the recognition of the constitutive role of sensuality in aesthetic experience. The representation obtained in this way is the basis of the idea of a beautiful thing. Beauty comes from form which is related to the species of a thing. God is Beauty as such. Therefore, the explanation of the impression received from the experience of beauty is connected with the ability of contemplation in the act of vision of things. They impressed the perfect image of the Creator. This image raises our cognitive faculty to the ultimate level of aesthetic evaluation. And despite the fact that Denis did not raise a created beauty to the level of a self-sufficient object of knowledge we may see that a gradual movement in this direction was being made.
Making Marx a Chinese: Marxism and Confucianism in modern China
Authors:   Beijing Normal University, Zhang Yanqiu
Published: October 2023

The paper considers the character of relationships between the Confucian tradition, the representation of the entire Chinese culture, and Marxist doctrine in the social, economic and political realms of modern China. At first glance, Marx’s doctrine is suggested to be something alien to the Chinese mind. Nevertheless, the study of the experts’ positions in Marxism and Confucianism, the analysis of the relationship between the two doctrines in the proposed perspective, allows us to identify a growing necessity in the modernization of Confucianism. The paper discusses and compares the main ideas of two scientific studies that relate to human conditions, as well as the corresponding economic and social structure. Taking it into consideration, we came to the conclusion that Marxism, having provoked a discussion and brought Confucianism out of stagnation, became a deliverer of the Chinese culture from the torturous conservative values. The consilience of the main intentions of these two doctrines, its full potential, which is still do be discovered, plays an important part. Such a synthesis provides the emergence and fruitfulness of the original strategy of the development of communism in China, which could be called “socialism with Chinese specifications”. Thus, we conclude that both doctrines, Confucianism as well as Marxism, are equally complementary elements to each other in the current intellectual life in modern China. At the same time, we cannot help noticing that some experts tend to overestimate the importance of one of the elements at the expense of the other, and such studies also require thorough analysis.
Whiteheadian process thought and the philosophy of Russian cosmism
Authors:   Lomonosov Moscow State University, Buchnev Danila V.
Published: October 2023

This article attempts to interpret the philosophy of Russian natural-scientific cosmism in terms of process thought. As the most developed version of this strategy of thinking, Whitehead’s process philosophy is considered. In the course of a comparative analysis of Whitehead’s philosophy with the ideas of the Russian cosmists A. L. Chizhevsky, K. E. Tsiolkovsky and V. I. Vernadsky the ideological, conceptual and terminological proximity of cosmists to process philosophy, and hence process thought strategy is revealed. A number of key concepts of process philosophy that are discussed in the article: novelty, event, organism, emotional experience, prehension, concrescence. The comparative analysis of Whitehead’s philosophy and the ideas of Russian cosmists based on the works of A. L. Chizhevsky, K. E. Tsiolkovsky and V. I. Vernadsky reveals the philosophical, conceptual and terminological similarity of the cosmists and process thought and, therefore, the process strategy of thinking. Referring to the poetic and scientific heritage of A. L. Chizhevsky, the authors find an outstanding example of a holistic worldview and an organicist attitude toward being. The central ideas of K. E. Tsiolkovsky are those of panpsychism, unification and community. Finally, it becomes known that V. I. Vernadsky pays close attention to the philosophical foundations of a naturalist scientist’s work in his studies. It is noted that Whitehead’s philosophy of process seems to him the most appropriate in this respect. Thus, organicism position; eco-oriented worldview; embedding man in the logic of nature; the priority of societies, nexus and relationships over individuals; ontology of holistic (cosmic) vision of reality; panpsychism; aestheticization of the cosmological process — these and other facets of process thought in the works of the cosmists make it possible to classify Russian natural-scientific cosmism as a processual mode of thought.
A numerical model to simulate the vertical velocity distribution in an open channel with double-layered rigid vegetation
Authors: Xuan Weidong , Bai Yu
Published: October 2023

Vegetation flow is more and more widely studied by scholars at home and abroad because it is an important condition affecting river water quality. However, most of the studies were carried out based on the data of indoor experimental flumes, because the vegetation conditions in nature are more complex. The analytical solution of the flow velocity based on indoor conditions often has some problems when applied to practical projects. Therefore, we propose a numerical method based on the lattice Boltzmann method to simulate the vertical velocity distribution in an open channel with double-layered rigid vegetation. This method has high simulation accuracy in different vegetation conditions. At the same time, because the lattice Boltzmann method is more conducive to simulating complex boundary conditions, it is easier to combine with a multi-layered rigid vegetation flow and a flexible vegetation flow in nature after improvement, providing a basis for the application of indoor theoretical results to the outdoor.
Water, sanitation and hygiene challenges of forcibly displaced Myanmar nationals in Rohingya camps in Bangladesh
Authors: Shapna Khusnur Jahan , Hasan Kamrul , Kabir Kazi Humayun , Li Jianfeng , Hossain Md. Lokman
Published: October 2023

Improved water, sanitation and hygiene (WASH) facilities in water-scarce areas is one of the most important barriers to improving the standards of people's life, which is even worse in a locality with forcibly displaced people (e.g., nearly 1 million Rohingya refugees in Bangladesh). In attempting to understand the extent of vulnerability and risks of WASH facilities, their impacts, and adaptive practices in the communities, an exploratory study has been carried out in five selected camps (13, 15, 16, 24 and 27) in Cox's Bazar, Bangladesh. Examination of water facilities shows that households in camps 13, 15 and 16 suffered from an adequate supply of water during summer as there is no direct access to surface water from adjacent water reservoirs, while camps 24 and 27 have such facilities. The frequency of water shortage for drinking purposes in camps 13, 15 and 16 was not so severe as in camps 24 and 27. Drinking water collectors had to spend 3–5 h in queues. All latrines were communal/shared latrines, which made users feel uncomfortable and vulnerable. This study implies that WASH facilities need to be reinforced, and community sensitization on WASH behavior needs to be strengthened to reduce WASH-related health hazards.
Actitudes y comportamientos de mujeres de clase alta limeña sobre el trabajo doméstico en el contexto de la pandemia por covid-19
Authors: Kogan Liuba
Published: October 2023

La pandemia por covid-19 generó cambios en los comportamientos y las actitudes de 17 empleadoras (casadas durante la década de los 50 y 60) de clase alta limeña que entrevistamos cuando se vieron en la necesidad de prescindir de trabajadoras del hogar por miedo al contagio. Argumentamos que las empleadoras se adaptaron a los cambios de modo positivo porque desarrollaron estrategias para liberarse del trabajo repetitivo y duro que realizaban las trabajadoras del hogar antes de la pandemia. Encontramos actitudes diversas sobre el trabajo doméstico como categoría ocupacional, las labores del hogar y quienes las ejecutan: las empleadoras, sus esposos y las trabajadoras del hogar.
Regulação da aprendizagem na didática profissional
Authors: Alves Felipe Omena Marques , Gomes Alex Sandro , Laurendon Candy Estelle Marques
Published: October 2023

A Didática Profissional é uma corrente de origem francesa que visa compreender o desenvolvimento de adultos com ênfase na formação profissional e na análise do trabalho. Este artigo apresenta uma revisão sistemática da literatura cujo objetivo foi identificar e analisar estudos sobre a regulação da aprendizagem na Didática Profissional com vista à formação de competências profissionais. Foram encontrados 83 artigos em 6 diferentes repositórios digitais, dos quais 26 foram analisados de acordo com as questões norteadoras da investigação. Os resultados obtidos indicam a predominância de análises do exercício profissional na docência, especialmente na área de Exatas, entretanto, os trabalhos são majoritariamente pesquisas bibliográficas com poucos relatos de experiências. Embasado na relevância da temática e com base nas discussões desta pesquisa, considera-se que a literatura carece de abordagens que investiguem apropriadamente formas explícitas de regulação e da utilização de instrumentos para análise do trabalho voltados ao desenvolvimento de competências profissionais.
The Therapeutic Effect of Natural Compounds on Osteoporosis
through Ferroptosis
Authors: Zhang Yong , Qu Zechao , Zhao Yiwei , Zhang Bo , Gong Yining , Wang Xiaohui , Gao Xiangcheng , Wang Dong , Yan Liang
Published: October 2023

Ferroptosis is a newly discovered non-apoptotic cell death whose key is lipid
peroxidation. It has been reported that ferroptosis is involved in the occurrence and development
of tumors and nervous system and musculoskeletal diseases. Cellular ferroptosis
contributes to the imbalance of bone homeostasis and is involved in the development
of osteoporosis; however, the detailed mechanism of which is still unclear though
it may provide a new direction for anti-osteoporosis. The current drugs used in the treatment
of osteoporosis, such as bisphosphonates and teriparatide, have many side effects,
increasing people's search for natural compounds to treat osteoporosis. This review paper
briefly summarizes the current research regarding the mechanisms of ferroptosis and
natural anti-osteoporosis compounds targeting its pathway.
The Role of Tissue Factor In Signaling Pathways of Pathological
Conditions and Angiogenesis
Authors: Heidari Zahra , Naeimzadeh Yasaman , Fallahi Jafar , Savardashtaki Amir , Razban Vahid , Khajeh Sahar
Published: October 2023

Tissue factor (TF) is an integral transmembrane protein associated with the
extrinsic coagulation pathway. TF gene expression is regulated in response to
inflammatory cytokines, bacterial lipopolysaccharides, and mechanical injuries. TF
activity may be affected by phosphorylation of its cytoplasmic domain and alternative
splicing. TF acts as the primary initiator of physiological hemostasis, which prevents
local bleeding at the injury site. However, aberrant expression of TF, accompanied by
the severity of diseases and infections under various pathological conditions, triggers
multiple signaling pathways that support thrombosis, angiogenesis, inflammation, and
metastasis. Protease-activated receptors (PARs) are central in the downstream
signaling pathways of TF. In this study, we have reviewed the TF signaling pathways in
different pathological conditions, such as wound injury, asthma, cardiovascular
diseases (CVDs), viral infections, cancer and pathological angiogenesis. Angiogenic
activities of TF are critical in the repair of wound injuries and aggressive behavior of
tumors, which are mainly performed by the actions of vascular endothelial growth
factor (VEGF) and hypoxia-inducible factor-1 (HIF1-α). Pro-inflammatory effects of TF
have been reported in asthma, CVDs and viral infections, including COVID-19, which
result in tissue hypertrophy, inflammation, and thrombosis. TF-FVII induces
angiogenesis via clotting-dependent and -independent mechanisms. Clottingdependent angiogenesis is induced via the generation of thrombin and cross-linked
fibrin network, which facilitate vessel infiltration and also act as a reservoir for
endothelial cells (ECs) growth factors. Expression of TF in tumor cells and ECs
triggers clotting-independent angiogenesis through induction of VEGF, urokinase-type
plasminogen activator (uPAR), early growth response 1 (EGR1), IL8, and cysteine-rich
angiogenic inducer 61 (Cyr61).
Technological Parameters of Microfiltration in the Production of Micellar
Casein Concentrate
Authors: Melnikova Elena I. , Stanislavskaya Ekaterina B. , Bogdanova Ekaterina V.
Published: October 2023

Background::

There are many different factors that influence the process of microfiltration,
including membrane pore size, pressure, temperature, and membrane origin. Studying the
joint influence of technological parameters in order to justify rational modes of microfiltration is
relevant.

Objective::

This research aimed to define the rational technological parameters of microfiltration,
which allow to achieve the target parameters of retentate in the process of obtaining micellar casein
concentrate.

Methods::

Standard and modified methods and techniques have been used in the process of experimental
research. The mathematical processing was carried out by methods of mathematical statistics
according to several trials data at three stage sequence.

Results::

As a result of experimental investigations, the applicability of ceramic membranes for microfiltration
of skim milk has been shown. The rational pore size has been established as 0,1 μm.
To obtain the micellar casein concentrate, it is advisably to carry out the microfiltration of skim
milk to the mass fraction of dry solids in concentrate (13 ± 3) %, followed by two-phase diafiltration
with a double volume of reverse osmosis water. The rational operating conditions, allowing
to get the target value of protein fractions correlation, have been established, as described as follows:
input pressure as 0,2 – 0,3 MPa, and temperature as 10 – 15°С.

Conclusion::

The analysis of microfiltration concentrates and permeates composition of raw milk,
including vitamins and minerals content, showed both their high nutritional and biological value
and the viability of further processing into food ingredients, including the ingredients for the specialized
food products.
Hydrothermally Synthesized Boletus Brucella-derived Carbon Quantum Dots as a Fluorescent Probe for the Detection of Vitamin B2
Authors: Wan Qiang , Li Rong , Ren Meiping , Ke Gang
Published: October 2023

Background:

In the paper, Boletus Brucella was used as carbon source material to
prepare carbon dots (CDs) by one-step hydrothermal method. The CDs had high quantum yield
and high photostability.

Methods:

A range of characterization studies were conducted on CDs, and the results showed
that the average particle size of CDs was 5 nm, emitting blue fluorescence. The optimal excitation
wavelength was 337 nm, and the emission wavelength was 440 nm.

Results:

Based on the static quenching, the fluorescence of CDs could be effectively quenched
by VB2. Therefore, a highly sensitive and selective fluorescent probe for detecting VB2 was
constructed. The CDs were successfully used to detect tablets, human blood, and urine.

Conclusion:

The recovery rate of VB2 was 97.55~99.45%, and the relative standard deviation
was 1.29~3.76 (n=3).
Organoids Research for Colorectal Cancer: Promising Approach for
Precision Medicine, their Applications and Future Perspectives
Authors: Singh Sonia , Ahuja Ashima , Ramankutty Raghavan , Ramaswamy Sarada
Published: October 2023

Background:

Organoids are three-dimensional (3D) constructs designed to emulate the
complexity and functionality of organs in the body. Organoids have recently been used as powerful
instruments for modeling and investigating several diseases, including colorectal cancer. Colorectal
cancer is caused by altering colonic epithelial cells, which produce adenomas and carcinomas.

Objective:

The objective of present study was to investigate impact of organoids on colorectal cancer
and their therapeutic outcome in cancer research. Organoids can be grown from stem cells in
vitro, which closely resemble the structure and function of the organ they are derived from. They
have been used in a variety of research applications, including disease modeling, drug screening,
and personalized medicine. Organoids have allowed researchers to understand better the mechanisms
underlying colorectal cancer initiation, progression, and resistance to therapy.

Methods:

The literature review was surveyed, and keywords related to cancer management, organoids,
modelling, personized medicine, 3D structures were screened for colorectal cancer management
were screened in SCI-hub, SCOPUS, WOS, and ABC Journals.

Results:

The findings of studies suggested that organoids derived from patient tumors can recapitulate
the histopathology and genetic alterations of the original tumor, making them a valuable tool
for personalized medicine.

Conclusion:

Organoids have been used to develop high-throughput drug screening assays and investigate
the tumor microenvironment's contribution to colorectal cancer progression. In this review,
we summarize recent advances in the use of organoids to study colorectal cancer and discuss
their potential applications in the clinic.
Multivariate Statistical 2D QSAR Analysis of Indenoisoquinoline-based Topoisomerase-
I Inhibitors as Anti-lung Cancer Agents
Authors: Singh Supriya , Mangla Bharti , Javed Shamama , Kumar Pankaj , Ahsan Waquar
Published: October 2023

Background:

Indenoisoquinoline-based compounds have shown promise as topoisomerase-I inhibitors,
presenting an attractive avenue for rational anticancer drug design. However, a detailed QSAR study on
these derivatives has not been performed till date.

Objective::

To study aimed to identify crucial molecular features and structural requirements for potent topoisomerase-
1 inhibition.

Methods:

A comprehensive two-dimensional (2D) QSAR analysis was performed on a series of 49 indenoisoquinoline
derivatives using TSAR3.3 software. A robust QSAR model based on a training set of 33 compounds
was developed achieving favorable statistical values: r2 = 0.790, r2CV = 0.722, f = 36.461, and s = 0.461. Validation
was conducted using a test set of nine compounds, confirming the predictive capability of the model (r2 =
0.624). Additionally, artificial neural network (ANN) analysis was employed to further validate the significance
of the derived descriptors.

Results:

The optimized QSAR model revealed the importance of specific descriptors, including molecular volume,
Verloop B2, and Weiner topological index, providing essential insights into effective topoisomerase-1 inhibition.
We also obtained a robust partial least-square (PLS) analysis model with high predictive ability (r2 =
0.788, r2CV = 0.743). The ANN results further reinforced the significance of the derived descriptors, with strong
r2 values for both the training set (r2 = 0.798) and the test set (r2 = 0.669).

Conclusion::

The present 2D QSAR analysis offered valuable molecular insights into indenoisoquinoline-based topoisomerase-
I inhibitors, supporting their potential as anti-lung cancer agents. These findings contribute to the rational design
of more effective derivatives, advancing the development of targeted therapies for lung cancer treatment.
Medicinal Herbs for the Treatment of Peptic Ulcers
Authors: Tiwari Divyansh , Alam Aftab , Dhoundiyal Shivang , Sharma Shaweta , Yadav Shikha
Published: October 2023

:

Peptic ulcers are common gastrointestinal disorders characterized by the erosion of
the stomach lining, duodenum, or esophagus. Conventional treatments, such as proton pump inhibitors and antibiotics for Helicobacter pylori eradication, have been the mainstay of therapy.
However, the emergence of drug resistance and potential side effects have led to the exploration
of alternative and complementary approaches, including medicinal herbs. This comprehensive
review examines the potential use of medicinal herbs in the management of peptic ulcers. Ten
herbal remedies, including Liquorice, Slippery Elm, Marshmallow Root, Aloe Vera, Chamomile,
Ginger, Turmeric, Meadowsweet, Fenugreek, and Cabbage, are analyzed for their therapeutic
properties and scientific research findings. These herbs have demonstrated anti-inflammatory,
antimicrobial, and mucoprotective effects that may support ulcer healing and symptom relief.
Herbal formulations, such as teas, capsules, tablets, and extracts, offer convenient delivery
methods for patients seeking herbal remedies. However, safety considerations and potential
herb-drug interactions must be carefully monitored. Integrating herbal remedies with conventional treatments presents a comprehensive approach to peptic ulcer management. By combining
these therapies, patients may experience enhanced therapeutic outcomes and improved quality of
life. Dietary recommendations also play a crucial role, with the inclusion of soothing and beneficial foods, while avoiding trigger foods that may exacerbate symptoms. As the evidence base
grows, collaborative efforts between traditional herbal medicine practitioners and mainstream
medical professionals are vital to ensure safe and effective integration.
Importance of Nidra: A Review
Authors: Kavita G. Ambe  , Pasha Sheikh
Published: October 2023

Nidra is derived from the root "Dra" with a prefix 'N'. The root "Dra" means undesired. Therefore, Nidra is considered as state in which there will be no desire. Nidra is one of the important pillars of Trayopsthmbhas. When the mind including sensory and motor organs is exhausted and they dissociate themselves from their objects, then the individual sleeps. Deprived and excessive sleep takes away both happiness and longevity. The same sleep, if properly enjoyed brings happiness and longevity in human beings as real knowledge brings about spiritual power in a Yogi.
Intervention of Amavata w.s.r. to Rheumatoid Arthritis through Ayurveda : A Single Case Study
Authors: Kritika  , Niranjan Rao  , Padmakiran C.
Published: October 2023

Amavata is the systemic disorder in which pathogenic constituents are mainly Aama and Vata. The symptoms of Amavata are identical to Rheumatoid arthritis. It is an auto-immune and most common persistent inflammatory disease occurring throughout the world in all ethnic groups with a male to female ratio of 1:2-3. Amavata, is explained in Laghutrayees and was first time described in Madhav Nidana as a separate clinical entity in the 7th century. In modern medicine treatment has its limitations, whereas in Ayurveda, its effective management is detailed for its different states. Moreover, Panchkarma has potent Shroto-vishodhna effect and is found as a promotive, preventive and curative measure in the patient of rheumatoid arthritis. In this case study a 14 year old diagnosed case of Amavata has been treated with Alepa, Dhanyamla Dhara, Vaitarna Basti as Shodhana and tablet AIMFLAM MR, Chitrakasavam as Samshamana Aushadha for 7 days and after that tablet FLEXOFEN, Vidangarishta, Kanchanar Guggulu as Samshamana Aushadha for 30 days and patient showed remarkable improvement in all the symptoms.
Beneficiated Coal Buying Process: Investigating Industrial Buying Behavior Models
Authors: Mishra Srinidhi , Singh Anurag
Published: October 2023

This research paper examines the buying process of beneficiated coal within coal-consuming industries, while considering different models of industrial buying behavior. Beneficiated coal refers to coal that has undergone a purification process to improve its quality and reduce impurities, making it suitable for industrial applications. The primary objective of this paper is to investigate and compare various models of industrial buying behavior in the specific context of the beneficiated coal market. This paper aims to provide valuable insights for coal suppliers and buyers to enhance their decision-making processes. The study focuses on the different stages involved in the buying process of beneficiated coal. Additionally, it explores the internal and external factors that influence industrial buyers when procuring beneficiated coal. The research analyzes each stage of the buying process, including problem recognition, information search, alternative evaluation, purchasing decision, and post-purchase evaluation. It also examines the internal and external factors influencing industrial buyers in their procurement of beneficiated coal, such as organizational considerations, market dynamics, and individual preferences. Furthermore, this research paper presents a comparative analysis of various models of industrial buying behavior, such as the Webster and Wind model and the Sheth model. The aim is to assess the applicability and effectiveness of these models in explaining the intricacies of the buying process within industries. By gaining a deeper understanding of the buying process and influential factors, coal suppliers and buyers can refine their marketing strategies, optimize their operations, and foster mutually beneficial relationships within the beneficiated coal market.
Exploring the Relationship Between Millennials’ Perception of Preferential Treatment and Brand Intimacy: Empirical Study on Hotel and Tourism Industry
Authors: John Riba K , Joseph Mathew
Published: October 2023

From generation to generation, it is evident that on and off changes are observed in individuals' characteristics, values, and consumption patterns. These changes invariably occur for various reasons, including; global transformations, technological advancement, changes in views and attitudes of people, progress in education and so on. The age cohorts, being exposed to these changes, develop a momentous difference in attitudes, perceptions, likes and dislikes, consumption patterns, loyalty factors, etc. Millennials are considered as emotional and least loyal, yet they are economically robust, technology savvy and heavy online shoppers, which makes them engaged with brands. This paper aims to study preferential treatments impact on millennials brand intimacy factors. Data were collected from individuals in the age group of 26 to 41. The result showed that the right type of preferential treatment significantly impacts the development of customer-brand intimate relations.
Odpowiedzialność Kościoła za sport dzieci i młodzieży w świetle nauczania papieża Franciszka
Authors: Dziubiński Zbigniew
Published: October 2023

Celem artykułu jest ukazanie nauczania papieża Franciszka na temat sportu i potrzeby aktywnej obecności Kościoła na jego gruncie, w oparciu o analizy papieskiego dokumentu zatytułowanego Dać z siebie to, co najlepsze, w chrześcijańskiej perspektywie sportu i osoby ludzkiej, ale także innych przesłań i wypowiedzi, stanowiska Franciszka dotyczącego odpowiedzialności Kościoła za tę wspólnotę dzieci i młodzieży, jaką jest sport. Z przeprowadzonych analiz wynika, że papież Franciszek potwierdza odpowiedzialność Kościoła za sport, który jest fenomenem globalnym, mającym liczne walory, które mogą być wykorzystane do pełnego i harmonijnego rozwoju młodego człowieka w jego wymiarze sprawnościowo-zdrowotnym, społeczno-kulturowym oraz etyczno-duchowym. Kościół przez swoich duszpasterzy uczestniczy we wszystkich jego wymiarach i etapach rozwoju, zarówno w budowaniu humanistycznego i personalistycznego jego oblicza, jak również w jego praktyce społecznej.
Guía de manejo de oocitos bovinos durante su colecta y envío para la producción in vitro de embriones
Authors: Cortés Escobar María de los Ángeles , Gómez López David Leonardo , Martínez Rocha Juan Felipe
Published: October 2023

El nacimiento de un ternero sano, a partir de un embrión implantado en una vaca receptora y que ha sido producido en condiciones de laboratorio, es el resultado de un complejo y coordinado proceso que involucra el trabajo colaborativo entre productores, profesionales de campo y de laboratorio. Durante la formación del embrión, el oocito no solo aporta la mitad del material genético, sino que también crea un entorno esencial para el éxito del desarrollo embrionario. Por lo tanto, las características de los oocitos seleccionados y el manejo que se le dé a los mismos, son factores que influyen directamente en la calidad de los embriones obtenidos en el laboratorio. La finalidad de esta cartilla es proporcionar una guía detallada con ilustraciones y recomendaciones prácticas que resaltan puntos importantes del proceso de búsqueda, selección, clasificación, embalaje y envío de los oocitos al laboratorio para realizar la producción in vitro de embriones bovinos.
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in East Asia and the Pacific Region: Longitudinal Trend Analysis (Preprint)
Authors: Lundberg Alexander L , Soetikno Alan G , Wu Scott A , Ozer Egon , Welch Sarah B , Liu Yingxuan , Hawkins Claudia , Mason Maryann , Murphy Robert , Havey Robert J , Moss Charles B , Achenbach Chad J , Post Lori Ann
Published: October 2023

BACKGROUND

This study updates the COVID-19 pandemic surveillance in East Asia and the Pacific region that we first conducted in 2020 with 2 additional years of data for the region.

OBJECTIVE

First, we aimed to measure whether there was an expansion or contraction of the pandemic in East Asia and the Pacific region when the World Health Organization (WHO) declared the end of the COVID-19 public health emergency of international concern on May 5, 2023. Second, we used dynamic and genomic surveillance methods to describe the dynamic history of the pandemic in the region and situate the window of the WHO declaration within the broader history. Finally, we aimed to provide historical context for the course of the pandemic in East Asia and the Pacific region.

METHODS

In addition to updates of traditional surveillance data and dynamic panel estimates from the original study, this study used data on sequenced SARS-CoV-2 variants from the Global Initiative on Sharing All Influenza Data to identify the appearance and duration of variants of concern. We used Nextclade nomenclature to collect clade designations from sequences and Pangolin nomenclature for lineage designations of SARS-CoV-2. Finally, we conducted a 1-sided t test to determine whether the regional weekly speed was greater than an outbreak threshold of 10. We ran the test iteratively with 6 months of data across the sample period.

RESULTS

Several countries in East Asia and the Pacific region had COVID-19 transmission rates above an outbreak threshold at the point of the WHO declaration (Brunei, New Zealand, Australia, and South Korea). However, the regional transmission rate had remained below the outbreak threshold for 4 months. In the rolling 6-month window t test for regional outbreak status, the final P value ≤.10 implies a rejection of the null hypothesis (at the α=.10 level) that the region as a whole was not in an outbreak for the period from November 5, 2022, to May 5, 2023. From January 2022 onward, nearly every sequenced SARS-CoV-2 specimen in the region was identified as the Omicron variant.

CONCLUSIONS

While COVID-19 continued to circulate in East Asia and the Pacific region, transmission rates had fallen below outbreak status by the time of the WHO declaration. Compared to other global regions, East Asia and the Pacific region had the latest outbreaks driven by the Omicron variant. COVID-19 appears to be endemic in the region, no longer reaching the threshold for a pandemic definition. However, the late outbreaks raise uncertainty about whether the pandemic was truly over in the region at the time of the WHO declaration.
Extrañas presencias en Nuestra América
Authors: Taboada Hernán G. H.
Published: October 2023

Desde los tiempos muy remotos América mantuvo relaciones con diversas partes del mundo, aunque la historiografía eurocéntrica suele privilegiar las que enlazaron el continente con Europa occidental. Intentando compensar dicha tendencia, el libro explora la cuestión de los posibles contactos precolombinos con el Islam, la presencia en la Colonia de muslimes y la llegada de griegos desde el imperio otomano, así como los efectos de la piratería norteafricana sobre las rutas entre España y las Indias y los diversos intentos de aclimatación del camello en América.
Time History Analysis of Various Shapes of Building Frame
Authors: Late Ms. Kajal K. , Nair Prof. V. V.
Published: October 2023

Abstract: The seismic performance of different building frames varies greatly according to shape. (I.e. geometric plans of the structure). By using the original earthquake forces, i.e. the various time history earthquakes, the realistic behaviour of buildings can be examined. The research is conducted on a variety of shapes, including G+05 storey L-shape, Plus-shape, and Square building frames. Two Time Histories namely El Centro (1940) and Bhuj (2001) are used to study the variation in the acceleration and displacement. The results are validated by performing study on the application software (ETABS 2018) study reveals that unsymmetrical building frames are less effective in resisting the seismic forces also out of the two Time History studied El Centro (1940) Time History is producing max acceleration and displacement in the structure.
Investigation of Cream and Ointment on Antimicrobial Activity of Mangifera Indica Extract
Authors: Sonkamble S Drx. Sumedh
Published: October 2023

Abstract: Medicinal plants have curative properties due to the presence of various complex chemicals substances of different composition which are found as secondary plants metabolites in one or more parts of these plants mangifera indica linn ( MIL) is a species of mango in the an acardiaceae family. Phyto constituents in the seed extract may be responsible for the antimicrobial activity of the plants. The purpose of the study was to formulate and evaluate the antimicrobial herbal ointments and creams form extract of the antimicrobial herbal ointments and cream bases in different concentration 1%,5%,and 10% the formulation ointments and cream of MIL .we're subjected to evaluation of uniformity of weight measured of ph viscosity, spreadability acute skin irritation study stability study and antimicrobial activity. Our study shows that M.I has high potential as an ointments and creams for topical use .thus the present study concluded that formulation of the M.I are safe and efficient carrier with potent antimicrobial activity.
A Conceptual Study of Vrikka and Vrikkaroga w.s.r. Chronic Kidney Disease: A Review
Authors: Kumar Dr. Mukesh , Rohila Dr. Saurabh Chandra , Sharma Dr. Rakesh Kumar
Published: October 2023

Abstract: The primary goal of Ayurveda is illness elimination and the preservation of healthy persons' health. Mutravaha sroto vikaras are described in Ayurvedic literature. Acharya Vagbhata explains Mutravaha sroto vikara has been classified as Mutra Atipravritti and Mutra Apravritti, which is a unique contribution. Mutra Atipravritti vikara, such as Prameha, and Mutra Apravrittija vikara, such as Asmari, Mutrakricchra, and others Mutraghata.Because the symptoms of Mutrakricchra and Mutraghata appear to be overlapping, Acharya Dalhana, Chakrapani, and Vijayarakshita have distinguished both entities. This distinction is due to the greater severity of "Vibhanda" or "Avarodha" (obstruction) in Mutraghata. Here Chronic Kidney Disease (CKD) encompasses a spectrum of different pathophysiologic process associated with abnormal kidney function. Manifested initially as a biochemical abnormality eventually the excretory, metabolic and endocrine dysfunctions of the kidney leads to the development of clinical symptoms and signs of renal failure, which are referred to as uremia. The disease, which begins in the kidney, spreads to all of the body's systems and tissues, eventually killing the patient. Chronic Kidney Disease is a global danger to health in general, and particularly to poor nations, because treatment is costly and must be sustained indefinitely.