bluuebunny/crossref_metadata_2025 huggingface dataset:
Temperature Field of Tool Engaged Cutting Zone for Milling of Titanium Alloy with Ball-End Milling
Authors: Yang Shucai , He Chunsheng , Zheng Minli , Wan Quan , Zhang Yuhua
Published: December 2018

When milling titanium alloy, the cutting temperature has a strong impact on the degree of tool wear and, in turn, tool life and the surface quality of the workpiece. The distribution of the temperature field on a tool’s rake face can be improved through the use of micro-textures, which help to reduce friction and, ultimately, wear on the tool. In this paper we present a new way to measure cutting temperature and examine heat distribution when milling titanium alloy with micro-textured ball-end milling tools. We first establish the heat flux density function for the contact area between the workpiece and the tool and then for the rest of the tool. Thermal stress simulation shows that adhesive wear tends to happen in the contact area and on the flank face, rather than at the tip of the tool, with the temperature distribution gradient for the rest of the tool being more uniform. The maximum value for thermal stress on the cutting edge was 2.0782 × 106 Pa. This decrease as you move away from the cutting edge along the contact area between the tool and the workpiece. Maximum deformation of the tool is also mainly concentrated at the principal contact point, with a value of 1.9445 × 10−9 m. This, too, decreases as you move away from the cutting edge and into the rest of the contact area. This research provides the basis for the optimization of tool structure and further investigation of the thermo-mechanical coupling behavior of micro-textured ball-end milling cutters when milling titanium alloy.
Tetra-glucopyranosyl Diterpene ent-Kaur-16-en-19-oic Acid and ent-13(S)-Hydroxyatisenoic Acid Derivatives from a Commercial Extract of Stevia rebaudiana (Bertoni) Bertoni
Authors: Perera Wilmer , Ghiviriga Ion , Rodenburg Douglas , Alves Kamilla , Wiggers Frank , Hufford Charles , Fronczek Frank , Ibrahim Mohamed , Muhammad Ilias , Avula Bharathi , Khan Ikhlas , McChesney James
Published: December 2018

Stevia rebaudiana and its diterpene glycosides are one of the main focuses of food companies interested in developing novel zero calorie sugar substitutes since the recognition of steviol glycosides as Generally Recognized as Safe (GRAS) by the United States Food and Drug Administration. Rebaudioside A, one of the major steviol glycosides of the leaves is more than 200 times sweeter than sucrose. However, its lingering aftertaste makes it less attractive as a table-top sweetener, despite its human health benefits. Herein, we report the purification of two novel tetra-glucopyranosyl diterpene glycosides 1 and 3 (rebaudioside A isomers) from a commercial Stevia rebaudiana leaf extract compounds, their saponification products compounds 2 and 4, together with three known compounds isolated in gram quantities. Compound 1 was determined to be 13-[(2-O-β-d-glucopyranosyl-6-O-β-d-glucopyranosyl-β-d-glucopyranosyl) oxy]ent-kaur-16-en-19-oic acid-β-d-glucopyranosy ester (rebaudioside Z), whereas compound 3 was found to be 13-[(2-O-β-d-glucopyranosyl-3-O-β-d-glucopyranosyl-β-d-glucopyranosyl) oxy]ent-hydroxyatis-16-en-19-oic acid -β-d-glucopyranosy ester. Two new tetracyclic derivatives with no sugar at position C-19 were prepared from rebaudiosides 1 and 3 under mild alkaline hydrolysis to afford compounds 2 13-[(2-O-β-d-glucopyranosyl-6-O-β-d-glucopyranosyl-β-d-glucopyranosyl) oxy]ent-kaur-16-en-19-oic acid (rebaudioside Z1) and 4 13-[(2-O-β-d-glucopyranosyl-3-O-β-d-glucopyranosyl-β-d-glucopyranosyl) oxy]ent-hydroxyatis-16-en-19-oic acid. Three known compounds were purified in gram quantities and identified as rebaudiosides A (5), H (6) and J (7). Chemical structures were unambiguously elucidated using different approaches, namely HRESIMS, HRESI-MS/MS, and 1D-and 2D-NMR spectroscopic data. Additionally, a high-quality crystal of iso-stevioside was grown in methanol and its structure confirmed by X-ray diffraction.
Quantum Chemical Calculations on CHOP Derivatives—Spanning the Chemical Space of Phosphinidenes, Phosphaketenes, Oxaphosphirenes, and COP− Isomers
Authors: Rey Alicia , Espinosa Ferao Arturo , Streubel Rainer
Published: December 2018

After many decades of intense research in low-coordinate phosphorus chemistry, the advent of Na[OCP] brought new stimuli to the field of CHOP isomers and derivatives thereof. The present theoretical study at the CCSD(T)/def2-TZVPP level describes the chemical space of CHOP isomers in terms of structures and potential energy surfaces, using oxaphosphirene as the starting point, but also covering substituted derivatives and COP− isomers. Bonding properties of the P–C, P–O, and C–O bonds in all neutral and anionic isomeric species are discussed on the basis of theoretical calculations using various bond strengths descriptors such as WBI and MBO, but also the Lagrangian kinetic energy density per electron as well as relaxed force constants. Ring strain energies of the superstrained 1H-oxaphosphirene and its barely strained oxaphosphirane-3-ylidene isomer were comparatively evaluated with homodesmotic and hyperhomodesmotic reactions. Furthermore, first time calculation of the ring strain energy of an anionic ring is described for the case of oxaphosphirenide.
High-Pressure Homogenization Pre-Treatment Improved Functional Properties of Oyster Protein Isolate Hydrolysates
Authors: Cha Yue , Wu Fan , Zou Henan , Shi Xiaojie , Zhao Yidi , Bao Jie , Du Ming , Yu Cuiping
Published: December 2018

The effects of HPH (high-pressure homogenization) pre-treatment on the functional properties of OPIH (oyster protein isolates hydrolysates) were studied. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis profiles, solubility, particle size distribution, zeta potential, surface hydrophobicity, emulsifying activity index and microstructure of emulsions were analyzed. Results indicated that HPH pre-treatment increased the accessibility of OPI to trypsin hydrolysis, resulting in decease in particle size, increase in solubility, absolute zeta potential, surface hydrophobicity and emulsifying activity index. In addition, HPH pre-treated OPIH emulsions became more uniform and the particle size of droplets decreased. These results revealed that HPH pre-treatment has the potential to modify the functional properties of OPIH.
Synergic Activity Against MCF-7 Breast Cancer Cell Growth of Nanocurcumin-Encapsulated and Cisplatin-Complexed Nanogels
Authors: Nguyen Ngoc The , Nguyen Ngoc Nhat Thanh , Tran Ngo The Nhan , Le Phung Ngan , Nguyen Thi Bich Tram , Nguyen Ngoc Hoa , Bach Long Giang , Doan Vu Nguyen , Tran Ha Le Bao , Le Van Thu , Tran Ngoc Quyen
Published: December 2018

Nanogel-based systems loaded with single anticancer drugs display miscellaneous effectiveness in tumor remission, gradually circumventing mutation and resistance in chemotherapy. Hence, the existence of dual-drug delivered nano-sized systems has been contemporaneous with drug development and preceded the conventional-dose chemotherapy. Among outstanding synergistic drug nanoplatforms, thermosensitive copolymer heparin-Pluronic F127 (Hep-F127) co-delivering cisplatin (CDDP) and curcumins (Cur) (Hep-F127/CDDP/Cur) has emerged as a notable candidate for temperature-responsive drug delivery. The procedure was based on the entrapment of curcumin into the hydrophobic core of bio-degradable co-polymer Hep-F127 while the hydrophilic drug CDDP subsequently conjugated to the backbone heparin to form the core-shell structure. The copolymer was characterized by Fourier transform infrared (FT-IR) spectrophotometry, Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS), to corroborate the successful synthesis and via HPLC along with AES-ICP to evaluate the high drug loading along with a controllable release from the nano-gels. A well-defined nano-shell with size in the 129.3 ± 3.8 nm size range could enhance higher the efficacy of the conjugated-CDDP to Hep-F127 than that of single doses. Moreover, the considerable amount of dual-drug released from thermosensitive nanogels between different conditions (pH = 7.4 and pH = 5.5) in comparison to CDDP from Hep-F127 partially indicated the significantly anti-proliferative ability of Hep-F127/CDDP/Cur to the MCF-7 cell line. Remarkably, drug testing in a xenograft model elucidates the intricate synergism of co-delivery in suppressing tumor growth, which remedies some of the problems affecting in cancer chemotherapy.
Permeability Characteristics of a New Antifungal Topical Amphotericin B Formulation with γ-Cyclodextrins
Authors: López-Castillo Carmen , Rodríguez-Fernández Carmina , Córdoba Manuel , Torrado Juan J.
Published: December 2018

Amphotericin B is a low soluble broad-spectrum antifungal agent. Cyclodextrins can be added to amphotericin formulations to enhance both their solubility and antifungal properties. Semisolid amphotericin formulations containing gamma cyclodextrin (AGCD) were prepared and compared with two reference formulations—one of them without any solubility enhancer (A) and the other with DMSO (ADMSO). Rheological, the permeability through hairless mouse skin and antifungal characteristics of the different formulations were evaluated. All three semisolid formulations show low thixotropy characteristics. ADMSO was the formulation with the least consistency, lowest viscosity, and greatest extensibility. The AGCD formulation had the opposite behavior and had both the greatest consistency and viscosity and the lowest extensibility. The lowest permeability was obtained with the reference A formulation while both AGCD and ADMSO had a similar permeability enhancement. According to the antimicrobial in vitro efficacy trials, the AGCD formulation showed 45–60% more activity than the reference A formulation. It can be concluded that γ-cyclodextrin is a useful excipient to improve the solubility, permeability, and antifungal activity of amphotericin B in semisolid topical formulations.
Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
Authors: Glomb Teresa , Szymankiewicz Karolina , Świątek Piotr
Published: December 2018

Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these compounds was tested on cell lines of various cancers. In most publications, the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future.
Non-Supported Nickel-Based Coral Sponge-Like Porous Magnetic Alloys for Catalytic Production of Syngas and Carbon Bio-Nanofilaments via a Biogas Decomposition Approach
Authors: Ali Buthainah , Tasirin Siti , Aminayi Payam , Yaakob Zahira , Ali Nur , Noori Wadhah
Published: December 2018

Porous Ni, Ni-Co, Ni-Fe, and Ni-Cu magnetic alloys with a morphology similar to a giant barrel sponge were synthesized via a facile co-precipitation procedure and then by hydrogen reduction treatment. For the first time, the non-supported alloys with their unique morphology were employed in catalytic biogas decomposition (CBD) at a reaction temperature of 700 °C and 100 mL min−1 to produce syngas and carbon bio-nanofilaments, and the catalysts’ behavior, CH4 and CO2 conversion, and the carbon produced during the reaction were investigated. All of the equimolar alloy catalysts showed good activity and stability for the catalytic biogas decomposition. The highest sustainability factor (0.66) and carbon yield (424%) were accomplished with the Ni-Co alloy without any significant inactivation for six hours, while the highest carbon efficiency of 36.43 was obtained with the Ni-Co catalyst, which is considered relatively low in comparison with industry standards, indicating a low carbon production process efficiency, possibly due to the relatively high biogas flow rate. The higher activity of the Ni-Co alloy catalyst was associated with the synergistic impact between nickel and cobalt, allowing the catalyst to maintain a high stability throughout the reaction period. Moreover, highly uniform, interwoven carbon bio-nanofilaments with a parallel and fishbone structure were achieved.
Beating Thermal Deterioration of Magnetization with Mn4C and Exchange Bias in Mn–C Nanoparticles
Authors: Si Ping-Zhan , Wang Xin-You , Ge Hong-Liang , Qian Hui-Dong , Park Jihoon , Yang Yang , Li Yin-Sheng , Choi Chul-Jin
Published: December 2018

The magnetization of most materials decreases with increasing temperature due to thermal deterioration of magnetic ordering. Here, we show that Mn4C phase can compensate the magnetization loss due to thermal agitation. The Mn–C nanoparticles containing ferrimagnetic Mn4C and other Mn–C/Mn-O phases were prepared by using the traditional arc-discharge method. A positive temperature coefficient of magnetization (~0.0026 Am2 kg−1 K−1) and an exchange bias up to 0.05 T were observed in the samples. We ascribe the exchange bias to the co-existence of ferrimagnetic Mn4C/Mn3O4 and antiferromagnetic α-Mn(C)/MnO phases. The positive temperature coefficient of magnetization of the samples was ascribed to the presence of Mn4C phase, which is considered as a Néel’s P-type ferrimagnet.
Impact of Nano-Scale Distribution of Atoms on Electronic and Magnetic Properties of Phases in Fe-Al Nanocomposites: An Ab Initio Study
Authors: Miháliková Ivana , Friák Martin , Jirásková Yvonna , Holec David , Koutná Nikola , Šob Mojmír
Published: December 2018

Quantum-mechanical calculations are applied to examine magnetic and electronic properties of phases appearing in binary Fe-Al-based nanocomposites. The calculations are carried out using the Vienna Ab-initio Simulation Package which implements density functional theory and generalized gradient approximation. The focus is on a disordered solid solution with 18.75 at. % Al in body-centered-cubic ferromagnetic iron, so-called α -phase, and an ordered intermetallic compound Fe 3 Al with the D0 3 structure. In order to reveal the impact of the actual atomic distribution in the disordered Fe-Al α -phase three different special quasi-random structures with or without the 1st and/or 2nd nearest-neighbor Al-Al pairs are used. According to our calculations, energy decreases when eliminating the 1st and 2nd nearest neighbor Al-Al pairs. On the other hand, the local magnetic moments of the Fe atoms decrease with Al concentration in the 1st coordination sphere and increase if the concentration of Al atoms increases in the 2nd one. Furthermore, when simulating Fe-Al/Fe 3 Al nanocomposites (superlattices), changes of local magnetic moments of the Fe atoms up to 0.5 μ B are predicted. These changes very sensitively depend on both the distribution of atoms and the crystallographic orientation of the interfaces.
Removal of Arsenic(III) from Aqueous Solution Using Metal Organic Framework-Graphene Oxide Nanocomposite
Authors: Chowdhury Tonoy , Zhang Lei , Zhang Junqing , Aggarwal Srijan
Published: December 2018

MIL-53(Al)-graphene oxide (GO) nanocomposites of different GO to MIL-53(Al) mass ratios (1% to 25% GO) were synthesized and tested for removal of arsenite (As(III)), which is a well-known groundwater contaminant. The properties of MIL-53(Al)-GO nanocomposites were characterized using X-ray Diffraction (XRD), Fourier Transform Infrared (FT-IR) Spectroscopy, Brunauer-Emmett-Teller (BET) surface area measurements, and Scanning Electron Microscopy (SEM). Batch experiments were performed on MIL-53(Al)-GO nanocomposites for As(III) adsorption in aqueous solutions to investigate adsorption kinetics and isotherm behavior under varying environmental conditions. The effects of solution pH (2 to 11), initial As(III) concentrations (10–110 mg/L), adsorbent dosage (0.2–3.0 g/L), and temperature (298–318 K) on As(III) adsorption were investigated. MIL-53(Al)-GO nanocomposites showed higher adsorption of As(III) than pristine MIL-53(Al) and GO individually. As (III) removal was optimized at a ratio of 3% GO in the MIL-53(Al)-GO nanocomposite, with an adsorption capacity of 65 mg/g. The adsorption kinetics and isotherms followed pseudo-second-order and Langmuir isotherm models, respectively. Overall, these results suggest that MIL-53(Al)-GO nanocomposite holds a significant promise for use in the remediation of As (III) from groundwater and other aqueous solutions.
Scaffolds for Chondrogenic Cells Cultivation Prepared from Bacterial Cellulose with Relaxed Fibers Structure Induced Genetically
Authors: Jacek Paulina , Szustak Marcin , Kubiak Katarzyna , Gendaszewska-Darmach Edyta , Ludwicka Karolina , Bielecki Stanisław
Published: December 2018

Development of three-dimensional scaffolds mimicking in vivo cells’ environment is an ongoing challenge for tissue engineering. Bacterial nano-cellulose (BNC) is a well-known biocompatible material with enormous water-holding capacity. However, a tight spatial organization of cellulose fibers limits cell ingrowth and restricts practical use of BNC-based scaffolds. The aim of this study was to address this issue avoiding any chemical treatment of natural nanomaterial. Genetic modifications of Komagataeibacter hansenii ATCC 23769 strain along with structural and mechanical properties characterization of obtained BNC membranes were conducted. Furthermore, the membranes were evaluated as scaffolds in in vitro assays to verify cells viability and glycosaminoglycan synthesis by chondrogenic ATDC5 cells line as well as RBL-2H3 mast cells degranulation. K. hansenii mutants with increased cell lengths and motility were shown to produce BNC membranes with increased pore sizes. Novel, BNC membranes with relaxed fiber structure revealed superior properties as scaffolds when compared to membranes produced by a wild-type strain. Obtained results confirm that a genetic modification of productive bacterial strain is a plausible way of adjustment of bacterial cellulose properties for tissue engineering applications without the employment of any chemical modifications.
Long Non-Coding RNAs Associated with Heterochromatin Function in Immune Cells in Psychosis
Authors: Sudhalkar Niyati , Rosen Cherise , Melbourne Jennifer K. , Park Mi Rae , Chase Kayla A. , Sharma Rajiv P.
Published: December 2018

Psychosis is associated with chronic immune dysregulation. Many long non-coding RNAs (lncRNAs) display abnormal expression during activation of immune responses, and play a role in heterochromatic regulation of gene promoters. We have measured lncRNAs MEG3, PINT and GAS5, selected for their previously described association with heterochromatin. Peripheral blood mononuclear cells (PBMCs) were isolated from blood samples collected from 86 participants with a diagnosis of psychosis and 44 control participants. Expression was assessed in relation to diagnosis, illness acuity status, and treatment with antipsychotic medication. We observed diagnostic differences with MEG3, PINT and GAS5, and symptom acuity effect with MEG3 and GAS5. Medication effects were evident in those currently on treatment with antipsychotics when compared to drug-naïve participants. We observed that clinical diagnosis and symptom acuity predict selected lncRNA expression. Particular noteworthy is the differential expression of MEG3 in drug naïve participants compared to those treated with risperidone. Additionally, an in vitro cell model using M2tol macrophages was used to test the effects of the antipsychotic drug risperidone on the expression of these lncRNAs using quantitative real-time PCR (qRT-PCR). Significant but differential effects of risperidone were observed in M2tol macrophages indicating a clear ability of antipsychotic medications to modify lncRNA expression.
Enhanced Omega-3 Polyunsaturated Fatty Acid Contents in Muscle and Edible Organs of Australian Prime Lambs Grazing Lucerne and Cocksfoot Pastures
Authors: Le Hung V. , Nguyen Quang V. , Nguyen Don V. , Otto John R. , Malau-Aduli Bunmi S. , Nichols Peter D. , Malau-Aduli Aduli E. O.
Published: December 2018

The enhancement of health-beneficial omega-3 long–chain (≥C20) polyunsaturated fatty acid (n-3 LC-PUFA) contents in the muscle, liver, heart, and kidney of Australian prime lambs through pasture grazing and supplementation with oil infused pellets was investigated. Forty-eight first-cross prime lambs were randomly assigned into a split-plot design with pasture type as the main plot effect and pellet supplementation as a sub-plot effect in a feeding trial that lasted for nine weeks. The n-3 LC-PUFA content in Longissimus dorsi muscle of all lambs was well above the 30 mg threshold for “omega-3 source” nutrition claim under the Australian Food Standards and Guidelines. Pasture type impacted the fatty acid contents in muscle, heart, and kidney of prime lambs. Lambs grazing cocksfoot grass only had high 18:3n-3 (ALA) and n-3 LC-PUFA contents (67.1 mg/100 g and 55.2 mg/100 g, respectively) in the Longissimus dorsi muscle, which was not significantly different (p > 0.8990) from the contents of lambs grazing only lucerne. Supplementation of pellets with or without oil infusion to grazing lambs generally decreased the ALA and n-3 LC-PUFA contents and increased the n-6/n-3 ratio in the Longissimus dorsi muscle. The fatty acid content in the internal organs of grazing lambs was also affected by pellet supplementation. The liver and kidney of grazing lambs were both “good sources” (60 mg/100 g) of omega-3. The cocksfoot grass showed considerable potential for producing healthy, premium quality meat with high contents of n-3 and n-3 LC-PUFA, which may consequently enhance the omega-3 intake of Australian lamb consumers.
Acute Effect of Resistant Starch on Food Intake, Appetite and Satiety in Overweight/Obese Males
Authors: Al-Mana Najlaa M. , Robertson M. Denise
Published: December 2018

Several studies have linked increased intake of dietary fibre to improvement in the management of body weight. Dietary fibre from resistant starch (RS) has been shown to have an impact on food intake in normal weight individuals, but its role in obesity is unknown. The present study aimed to investigate the short-term effects of RS on appetite, satiety and postprandial metabolism in overweight/obese subjects. In this single-blind randomized crossover study, overweight/obese healthy males consumed a test breakfast and lunch containing either 48 g RS or a placebo. Postprandial qualitative appetite, glucose, insulin, and GLP-1 were measured every 30 min for 7 h. Energy intake values from an ad libitum dinner and for a 24-h period were assessed. Acute consumption of RS at breakfast/lunch significantly reduced the energy intake at the ad libitum dinner (p = 0.017). No significant effect over 24 h or qualitative feelings of satiety were observed. Significant treatment × time effects were found for postprandial glucose (p = 0.004) for RS compared to placebo, with a trend for higher C-peptide concentrations following RS. The postprandial insulin and GLP-1 responses were not significantly different. RS may indeed have short-term beneficial effects in obese individuals.
Tectorigenin, a Flavonoid-Based Compound of Leopard Lily Rhizome, Attenuates UV-B-Induced Apoptosis and Collagen Degradation by Inhibiting Oxidative Stress in Human Keratinocytes
Authors: Noh Dongjin , Choi Jin Gyu , Huh Eugene , Oh Myung Sook
Published: December 2018

Ultraviolet (UV) light, a major risk factor for external skin photoaging, induces oxidative stress in skin. UV causes a breakdown of skin homeostasis by impairing the extracellular matrix and inducing cell death. Tectorigenin, a constituent of leopard lily (Belamcanda chinensis L.) rhizome, has been reported to possess antioxidant, hair-darkening, and anti-inflammatory activities; however, the effect of tectorigenin on UV-B-induced skin damage is unknown. Here, we investigated the anti-skin-damage effects of tectorigenin against UV-B-stimulated oxidative stress in human keratinocytes. We irradiated HaCaT cells with UV-B (25 mJ/cm2), followed by treatment with tectorigenin for 24 h. We found that tectorigenin decreased the levels of intracellular reactive oxygen species by increasing the expression of anti-oxidative enzymes, such as glutathione and catalase. Furthermore, tectorigenin inhibited apoptosis by reducing caspase-3- and Bcl-2-associated protein-X levels, and increasing Bcl-2 protein levels. Tectorigenin also decreased matrix metalloproteinase-1 levels and increased type 1 collagen levels, thus preventing collagen degradation. These data demonstrate that tectorigenin exerts anti-skin-damage effects in human keratinocytes by attenuating UV-B-induced hyper-oxidation, apoptosis, and collagen degradation.
Mid-Pregnancy Fructosamine Measurement—Predictive Value for Gestational Diabetes and Association with Postpartum Glycemic Indices
Authors: Gingras Véronique , Rifas-Shiman Sheryl L. , Switkowski Karen M. , Oken Emily , Hivert Marie-France
Published: December 2018

Screening for gestational diabetes mellitus (GDM) during pregnancy is cumbersome. Measurement of plasma fructosamine may help simplify the first step of detecting GDM. We aimed to assess the predictive value of mid-pregnancy fructosamine for GDM, and its association with postpartum glycemic indices. Among 1488 women from Project Viva (mean ± SD: 32.1 ± 5.0 years old; pre-pregnancy body mass index 24.7 ± 5.3 kg/m2), we measured second trimester fructosamine and assessed gestational glucose tolerance with a 50 g glucose challenge test (GCT) followed, if abnormal, by a 100 g oral glucose tolerance test (OGTT). Approximately 3 years postpartum (median 3.2 years; SD 0.4 years), we measured maternal glycated hemoglobin (n = 450) and estimated insulin resistance (HOMA-IR; n = 132) from fasting blood samples. Higher glucose levels 1 h post 50 g GCT were associated with higher fructosamine levels (Pearson’s r = 0.06; p = 0.02). However, fructosamine ≥222 µmol/L (median) had a sensitivity of 54.8% and specificity of 48.6% to detect GDM (area under the receiver operating characteristic curve = 0.52); other fructosamine thresholds did not show better predictive characteristics. Fructosamine was also weakly associated with 3-year postpartum glycated hemoglobin (per 1 SD increment: adjusted β = 0.03 95% CI [0.00, 0.05] %) and HOMA-IR (per 1 SD increment: adjusted % difference 15.7, 95% CI [3.7, 29.0] %). Second trimester fructosamine is a poor predictor of gestational glucose tolerance and postpartum glycemic indices.
Differential Scanning Calorimetry Analyses of Idebenone-Loaded Solid Lipid Nanoparticles Interactions with a Model of Bio-Membrane: A Comparison with In Vitro Skin Permeation Data
Authors: Montenegro Lucia , Castelli Francesco , Sarpietro Maria Grazia
Published: December 2018

Differential scanning calorimetry (DSC) has emerged as a helpful technique both to characterize drug delivery systems and to study their interactions with bio-membranes. In this work, we compared idebenone (IDE)-loaded solid lipid nanoparticle (SLN) interactions with bio-membranes assessed by DSC with previous in vitro skin penetration data to evaluate the feasibility of predicting IDE skin penetration using DSC analyses. In vitro interactions experiments were performed using multi-lamellar liposomes as a model of bio-membrane. Enthalpy changes (ΔH) and transition temperature (Tm) were assessed during nine repeated DSC scans to evaluate IDE-loaded SLN–bio-membrane interactions over time. Analyzing ΔH and Tm values for each scan, we observed that the difference of ΔH and Tm values between the first and the last scan seemed to be related to SLN ability to locate IDE in the epidermis and in the stratum corneum, respectively. Therefore, the results of this study suggest the possibility of qualitatively predicting in vitro IDE skin penetration from IDE-loaded SLN utilizing the calorimetric parameters obtained from interaction experiments between the carriers under investigation and a model of bio-membrane.
Enhanced Dissolution and Oral Bioavailability of Cyclosporine A: Microspheres Based on αβ-Cyclodextrins Polymers
Authors: Lahiani-Skiba Malika , Hallouard Francois , Bounoure Frederic , Milon Nicolas , Karrout Youness , Skiba Mohamed
Published: December 2018

Cyclosporine (CsA) has a selective property of suppressing various T-lymphocyte functions. This is of utmost importance in preventing allograft rejection by several organ transplantations, as well as in the treatment of systemic and local autoimmune disorders. However, the poor water solubility of CsA can be a major hurdle for its absorption into the blood stream, which leads to low bioavailability and thus less efficacy. The aim of this study was to prepare, characterize, and evaluate in vitro as well as in vivo, the potential of the innovative CsA drug delivery system. The latter contains CsA in spherical amorphous solid dispersion (SASD) which is embedded in an original α-cyclodextrin and β-cyclodextrin polymer mixture (Poly-αβ-CD) as a multifunctional amorphous carrier. The new developed SASD formulation showed that CsA was molecularly dispersed in αβ-cyclodextrins in an amorphous form, as was confirmed by physicochemical characterization studies. Interestingly, the peptide secondary structure, and thus, the drug activity was not impacted by the preparation of SASD as was shown by circular dichroism. Furthermore, the in vitro CsA release profile kinetics was almost identical to the commercially available product Neoral®. This study presents the first in vivo proof-of-concept for a novel drug delivery system based on Poly-αβ-CD containing CsA, with SASD allowing for increased bioavailibility. The pharmacokinetic parameters of cyclosporine A from the spherical spray-dried dispersion formulation was demonstrated in a “rat” animal model. For comparison, the commercially available Neoral® was studied. Importantly, the pharmacokinetic parameters were improved by extending Tmax from 2 to 3 h after the oral administration in rats, and eventually preventing the enterohepatic circulation. All these results clearly demonstrate the improved pharmacokinetic parameters and enhanced bioavailability of CsA in the new developed drug delivery system. These data demonstrated the superiority of the newly developed Poly-αβ-CD formulation for oral administration of the poorly soluble CsA in vivo without altering its secondary structure. Poly-αβ-CD can be a very useful tool for the oral administration of poorly water-soluble drugs.
Autologous Red Blood Cell Delivery of Betamethasone Phosphate Sodium for Long Anti-Inflammation
Authors: Zhang Xiumei , Qiu Mingfeng , Guo Pengcheng , Lian Yumei , Xu Enge , Su Jing
Published: December 2018

Although glucocorticoids are highly effective in treating various types of inflammation such as skin disease, rheumatic disease, and allergic disease, their application have been seriously limited for their high incidence of side effects, particularly in long term treatment. To improve efficacy and reduce side effects, we encapsulated betamethasone phosphate (BSP) into biocompatible red blood cells (RBCs) and explored its long acting-effect. BSP was loaded into rat autologous erythrocytes by hypotonic preswelling method, and the loading amount was about 2.5 mg/mL cells. In vitro, BSP loaded RBCs (BSP-RBCs) presented similar morphology, osmotic fragility to native RBCs (NRBCs). After the loading process, the loaded cells can maintain around 70% of Na+/K+-ATPase activity of natural cells. In vivo, a series of tests including survival, pharmacokinetics, and anti-inflammatory effect were carried out to examine the long-acting effect of BSP-RBCs. The results shown that the loaded cells could circulate in plasma for over nine days, the release of BSP can last for over seven days and the anti-inflammatory effect can still be observed on day 5 after injection. Totally, BSP-loaded autologous erythrocytes seem to be a promising sustained releasing delivery system with long anti-inflammatory effect.
Effect of Chemical Modification on Mechanical Properties of Wood-Plastic Composite Injection-Molded Parts
Authors: Sohn Joo Seong , Cha Sung Woon
Published: December 2018

Wood chips from furniture-manufacturing byproducts, which do not include adhesive or paint in the waste wood, were used for the flouring process and chemical modification of wood flour (WF). After chemical modification, the WF was mixed with polypropylene through extrusion compounding and injection-molding to prepare wood-plastic composite (WPC) injection-molded specimens for the American Society for Testing and Materials. Static contact angle measurements and stereomicroscope observations were performed. In this study, it was confirmed that the impact strength was improved by up to 55.8% and the tensile strength by up to 33.8%. The flexural modulus decreased marginally. As a result of WF chemical modification, the measured contact angle of WPC increased, which means that the wettability of the WPC specimen surface decreased. In addition, it was observed through stereomicroscopy that the whitening of the surface of the WPC specimen improved.
Self-Healing Cellulose Nanocrystals-Containing Gels via Reshuffling of Thiuram Disulfide Bonds
Authors: Li Wenyan , Lu Shengchang , Zhao Mengchan , Lin Xinxing , Zhang Min , Xiao He , Liu Kai , Huang Liulian , Chen Lihui , Ouyang Xinhua , Ni Yonghao , Wu Hui
Published: December 2018

Self-healing gels based on reshuffling disulfide bonds have attracted great attention due to their ability to restore structure and mechanical properties after damage. In this work, self-healing gels with different cellulose nanocrystals (CNC) contents were prepared by embedding the thiuram disulfide bonds into gels via polyaddition. By the reshuffling of thiuram disulfide bonds, the CNC-containing gels repair the crack and recover mechanical properties rapidly under visible light in air. The thiuram disulfide-functionalized gels with a CNC content of 2.2% are highly stretchable and can be stretched approximately 42.6 times of their original length. Our results provide useful approaches for the preparation of dynamic CNC-containing gels with implications in many related engineering applications.
Paddlewheel SBU based Zn MOFs: Syntheses, Structural Diversity, and CO2 Adsorption Properties
Authors: Lin Ting-Ru , Lee Cheng-Hua , Lan Yi-Chen , Mendiratta Shruti , Lai Long-Li , Wu Jing-Yun , Chi Kai-Ming , Lu Kuang-Lieh
Published: December 2018

Four Zn metal–organic frameworks (MOFs), {[Zn2(2,6-ndc)2(2-Pn)]·DMF}n (1), {[Zn2(cca)2(2-Pn)]·DMF}n (2), {[Zn2(thdc)2(2-Pn)]·3DMF}n (3), and {[Zn2(1,4-ndc)2(2-Pn)]·1.5DMF}n (4), were synthesized from zinc nitrate and N,N′-bis(pyridin-2-yl)benzene-1,4-diamine (2-Pn) with naphthalene-2,6-dicarboxylic acid (2,6-H2ndc), 4-carboxycinnamic acid (H2cca), 2,5-thiophenedicarboxylic acid (H2thdc), and naphthalene-1,4-dicarboxylic acid (1,4-H2ndc), respectively. MOFs 1–4 were all constructed from similar dinuclear paddlewheel {Zn2(COO)4} clusters and resulted in the formation of three kinds of uninodal 6-connected non-interpenetrated frameworks. MOFs 1 and 2 suit a topologic 48·67-net with 17.6% and 16.8% extra-framework voids, respectively, 3 adopts a pillared-layer open framework of 48·66·8-topology with sufficient free voids of 39.9%, and 4 features a pcu-type pillared-layer framework of 412·63-topology with sufficient free voids of 30.9%. CO2 sorption studies exhibited typical reversible type I isotherms with CO2 uptakes of 55.1, 84.6, and 64.3 cm3 g−1 at 195 K and P/P0 =1 for the activated materials 1′, 2′, and 4′, respectively. The coverage-dependent isosteric heat of CO2 adsorption (Qst) gave commonly decreased Qst traces with increasing CO2 uptake for all the three materials and showed an adsorption enthalpy of 32.5 kJ mol−1 for 1′, 38.3 kJ mol−1 for 2′, and 23.5 kJ mol−1 for 4′ at zero coverage.
Evaluation of Exfoliated Graphite to Graphene in Polyamide 66 Using Novel High Shear Elongational Flow
Authors: Hendrix Justin W. , Szeto Ryan , Nosker Thomas , Lynch-Branzoi Jennifer , Emge Thomas J.
Published: December 2018

Graphene has been publicized as the game changing material of this millennium. To this day, scalable production leading to exceptional material properties has been difficult to attain. Most methods require harsh chemicals, which result in destroying the graphene surface. A method was developed, exploiting high speed elongational flow in a novel designed batch mixer; creating a distribution of pristine few to many layer graphene flakes. The method focuses on exfoliating in a molten polyamide 66 (PA66) matrix, creating a graphene reinforced polymer matrix composite (G-PMC). The process revealed that high speed elongational flow was able to create few layer graphene. Graphite exfoliation was found driven in part by diffusion, leading to intercalation of PA66 in graphite. The intercalated structure lead to increases in the hydrogen bonding domain, creating anisotropic crystal domains. The thermal stability of the G-PMC was found to be dependent to the degree of exfoliation, PA66 crystal structure and composite morphology. The aim of this research is to characterize uniquely produced graphene containing polymer matrix composites using a newly created elongational flow field. Using elongational flow, graphite will be directly exfoliated into graphene within a molten polymer.
A Facile Fabrication of High Toughness Poly(lactic Acid) via Reactive Extrusion with Poly(butylene Succinate) and Ethylene-Methyl Acrylate-Glycidyl Methacrylate
Authors: Xue Bin , He Hezhi , Zhu Zhiwen , Li Jiqian , Huang Zhaoxia , Wang Guozhen , Chen Ming , Zhan Zhiming
Published: December 2018

As is an excellent bio-based polymer material, poly(lactic acid) (PLA)’s brittle nature greatly restricts its extensive applications. Herein, poly(butylene succinate) (PBS) was introduced to toughening PLA by melt blending using a self-made triple screw extruder through in situ reactive with ethylene-methyl acrylate-glycidyl methacrylate (EGMA). The effect of EGMA concentrations on the mechanical properties, morphology, interfacial compatibility of PLA/PBS blends were studied. Fourier transform infrared (FT-IR) results demonstrated that the epoxy group of EGMA reacts with the hydroxyl groups of PLA and PBS, which proved the occurrence of interfacial reactions among the tri-component. The significantly improved compatibility between PLA and PBS after EGMA incorporation was made evident by scanning electron microscope (SEM) characterization results. Meanwhile, the contact angle test predicted that the EGMA was selectively localized at the interface between PLA and PBS, and the result was verified by morphological analysis of cryofracture and etched samples. The EGMA improves the compatibility of PLA/PBS blends, and consequently leads to a significantly increased toughness with the elongation at break occurring 83 times more when 10 wt % EGMA was introduced than neat PLA, while impact strength also enhanced by twentyfold. Ultimately, the toughening mechanism of PLA based polymers was established based on the above analysis, exploring a new way for the extensive application for degradable material.
A Green Process for the Extraction and Purification of Hesperidin from Mexican Lime Peel (Citrus aurantifolia Swingle) that is Extendible to the Citrus Genus
Authors: Padilla de la Rosa J. Daniel , Ruiz-Palomino Priscilla , Arriola-Guevara Enrique , García-Fajardo Jorge , Sandoval Georgina , Guatemala-Morales Guadalupe M.
Published: December 2018

The processing of Mexican limes generates great amounts of peel as a by-product. Lime peel is mainly rich in the flavonoid hesperidin, whose bioactivity is oriented mainly to cardiovascular diseases and cancer. The purpose of this work was to develop a green process for the extraction and purification of hesperidin from Mexican lime peel. The extraction of hesperidin was investigated on a laboratory scale by varying the solvent composition and the solid-to-solvent ratio, and then scaling this process (volume: 20 L). Next, a purification process using adsorption resins was assessed: first through static tests to determine the adsorption efficiency with two resins (FPX66, EXA118), and then on a packed column with 80 mL of resin at 25 °C. Lab-scale extraction showed that the best conditions were a solid-to-solvent ratio of 0.33 g/mL and 60% ethanol. After using these conditions at pilot scale and concentrating the solution, the hesperidin content of the extract was 0.303 mg/mL. Through static tests, higher adsorption efficiencies were achieved with the EXA-118 resin and diluted extract (4:6 ratio with 10% dimethylsulfoxide, (DMSO)). Finally, the purification process on a packed column from the diluted extract (hesperidin concentration of 0.109 mg/mL) had a mean recovery efficiency of almost 90%.
Towards an Ecological Catholicism: Marian Pilgrimage in the Anthropocene
Authors: Traylor Sarah
Published: December 2018

This article analyzes how the author and environmental activist Carl Amery draws together the topics of Catholicism and ecological criticism in the pilgrimage novel Die Wallfahrer, or The Pilgrims (1986). The novel depicts the journeys of four pilgrims to the Marian shrine at Tuntenhausen in Bavaria. In their journeys towards the surprising and unorthodox Virgin Mary of Tuntenhausen, the pilgrims anticipate their ultimate journey towards Gaia, the earth goddess in Greek mythology, and the inspiration for the Gaia Hypothesis, which proposes that the Earth evolves as a system in which organisms are an active, fundamental component. This article explores how the novel recasts the pilgrim journey as a journey towards an ecological consciousness of humans’ creatureliness and increasingly detrimental impact on the web of life. Particular focus is placed on the way Amery dramatizes the connection between salvation history and the Gaia theory that has lately received renewed interest in the context of the Anthropocene debate.
Lament of a Wounded Priest: The Spiritual Journey of Job
Authors: Fortin Jean-Pierre
Published: December 2018

Acknowledging the complex redaction history which produced the Book of Job contained in the Jewish and Christian canonical scriptures, this article offers a spiritual interpretation of the text taking due account of its overall structure and major parts (prologue, main dialogical body and epilogue). With its focus on the formation of personal identity, spiritual theology grants access to a developmental understanding of the biblical narrative and characters. Undergirding this essay is the basic claim that in and with the book and figure of Job are found paradigmatic examples of how to become and remain human and faithful in and despite relentless undeserved suffering. The exploration of Job’s life in suffering leads to the discovery that the lament formulated by a faithful heart compellingly summons God to appear and speak, consecrating the human recipient as mediator of divine revelation and sacramental intercessor. Job’s wounded body and spirit reflect the spiritual journey he has completed and has been commissioned to invite others to undertake. Undeserved suffering can lead to transformative mystical encounters with God, if and when the human heart dares to believe to the end, giving voice to and challenging God from within relentless unjustifiable pain.
How and Why Education Counters Ideological Extremism in Finland
Authors: Niemi Pia-Maria , Benjamin Saija , Kuusisto Arniika , Gearon Liam
Published: December 2018

The intensification of radical and extremist thinking has become an international cause of concern and the fear related to terrorism has increased worldwide. Early 21st century public discourses have been correspondingly marked by hate speech and ideological propaganda spread from a variety of perspectives through the intensified presence of global social media networks. In many countries, governments have reacted to these perceived and actual threats by drafting policies and preventive programs and legal-security interventions to tackle radicalization, terrorism itself, as well as ideological extremism. Many of the current strategies point to the critical role of societal education. As a result, educational institutions have gained growing importance as platforms for different kinds of prevention protocols or counter-terrorism strategies. However, notably less attention has been paid on the consistencies of values between the aims of the educational strategies for preventing or countering ideological extremism and the core functions of education in fostering individual and societal well-being and growth. Using Finnish education as a case, this paper discusses the challenges and possibilities related to educational institutions as spaces for preventing violent extremism, with special regard to the religious and nationalistic ideologies that divert from those inherent in the national hegemony. This study highlights the need to plan counter-terrorism strategies in line with national educational policies through what we conceptualize as ‘institutional habitus’.
“It’s Almost Impossible to Speak about It”: Sexual Abuse, Forgiveness, and the Need for Restitution Rituals
Authors: Rudolfsson Lisa , Portin Fredrik
Published: December 2018

The focus of this research was on ways in which Christian congregations can address the concept of forgiveness when caring for victims of sexual abuse, and to make suggestions for a restitution mass as a possible way for congregations to work with these victims. Interviews with seven women and one man, who were victims of sexual abuse, were analyzed according to inductive thematic analysis. Our focus was on abuse that had occurred outside Church, i.e., not perpetrated by representatives for the Church. The informants described how attending services in Church could trigger their memories of sexual abuse, and they struggled to understand the concept of forgiveness; who they were to forgive and what made their forgiveness good enough. They expressed a need for the Church to offer them a safe space, rituals where their experiences would be acknowledged, and to meet with other victims of sexual abuse. We argue that representatives for the Church need to acquire knowledge about sexual abuse and its consequences before offering care. Further, the presence of victims of sexual abuse in a congregation demands that the congregation create appropriate conditions where the victim’s needs and concerns are put into focus. Addressing forgiveness and offering rituals must be done in such a way that it does not consolidate the victim’s feelings of exclusion, guilt, and shame.
Locking Status and Earthquake Potential Hazard along the Middle-South Xianshuihe Fault
Authors: Guo Rumeng , Zheng Yong , Tian Wen , Xu Jianqiao , Zhang Wenting
Published: December 2018

By combining the seismogenic environment, seismic recurrence periods of strong historical earthquakes, precise locations of small–moderate earthquakes, and Coulomb stress changes of moderate–strong earthquakes, we analyze the potential locking status of a seismically quiet segment of Xianshuihe fault between Daofu County and Kangding City (SDK). The interseismic surface velocities between 1999 and 2017 are obtained from updated global positioning system (GPS) observations in this region. After removing the post-seismic relaxation effect caused by the 2008 Mw 7.9 Wenchuan earthquake that occurred around the fault segment, the observed velocities reveal a pronounced symmetric slip pattern along the SDK trace. The far field slip rate is 7.8 ± 0.4 mm/a, and the fault SDK is confirmed to be in an interseismic silent phase. The optimal locking depth is estimated at 7 km, which is perfectly distributed on the upper edge of the relocated hypocenters. A moment deficit analysis shows cumulative seismic moment between 1955 and 2018, corresponding to an Mw 6.6 event. Finally, based on a viscoelastic deformation model, we find that moderate–strong earthquakes in the surrounding area increase the Coulomb stress level by up to 2 bars on the SDK, significantly enhancing the future seismic potential.