bluuebunny/crossref_metadata_2025 huggingface dataset:
FONTES DE MATÉRIA ORGÂNICA PARA OS SEDIMENTOS SUPERFICIAIS DO ESTUÁRIO DO RIO ITAPICURU (BAHIA - BRASIL)
Authors: Santana Juliana , Leal Iasmim , Queiroz Antonio , Assumpção Henrique , de Souza José , Zucchi Maria , de Albergaria-Barbosa Ana
Published: May 2023

ORGANIC MATTER SOURCES TO THE SUPERFICIAL SEDIMENT OF THE ITAPICURU RIVER ESTUARY (BAHIA - BRAZIL). The present study evaluated the sources of organic matter (O.M.) in the Itapicuru River estuary (IRE), which is in an environmentally protected area surrounded by the Atlantic Rainforest in the northeast of Brazil. Eleven sediment samples were collected along the study area. Total organic carbon (TOC) and the δ13C values were determined using an elemental analyzer coupled with an isotope ratio mass spectrometer. The n-alkanes composition was evaluated through gas chromatography coupled to a flame ionization detector. TOC and total n-alkanes concentrations ranged, respectively, from not detected to 0.72%, and from lower the limit of detection to 5024 ng g-1. There was a significant concentration of n-C22 and n-C24 in some samples showing bacterial production and recycling of O.M. Values of δ13C ranged from −27.6 to −21.9‰. Carbon preference index, terrestrial-aquatic ratio, aquatic production index, average chain length, and the ratio between n-C29 and n-C31 values ranged, respectively, from 1.42 to 4.11; 2.82 to 9.40; 0.00 to 0.25; 27.7 to 29.9; and 0.27 to 0.43. These results show that concentrations of O.M. to IRE are low, and its main source is C3 plants, such as those from mangroves. There is also the contribution of macrophytes.
A modelling approach to prepare synthetic urine for struvite precipitation studies
Authors: Soltani Saeede , Natividad-Marin Leynard , Schneider Philip Andrew
Published: May 2023

Nutrient recovery from wastewater is an effective strategy to prevent eutrophication and provide value for the treatment process. Human urine is a small but highly nutrient-rich stream in the total flux of domestic wastewater from which struvite (MgNH4PO4.6H2O) could be recovered and used as a fertiliser. Consequently, synthetic urine was used in most struvite precipitation studies, due to biohazard issues in real human urine. A modelling approach was developed to formulate synthetic urine recipes based on elemental urine composition, using matrix solving strategy to select and quantify chemical salts for synthetic urine preparation. The model also included mass balance, chemical speciation, and equilibrium dissociation expression for solution thermodynamics predictions in the formulated urine. In this study, synthetic solutions of fresh and stored urine were assessed with this model using Engineering Equation Solver (EES) software to calculate the quantity of salts, pH, ionic strength, and struvite saturation index. Simulation results in EES were successfully verified using PHREEQC simulations, while model validation comprised the examination of urine composition with their reported recipes.
Pegylation, a Successful Strategy to Address the Storage and Instability
Problems of Blood Products: Review 2011-2021
Authors: Mehrizi Tahereh Zadeh , Mirzaei Mehdi , Ardestani Mehdi Shafiee
Published: May 2023

Conjugation of polyethylene glycol (PEGylation) to blood proteins and cells has
emerged as a successful approach to address some of the issues attributed to the storage of blood
products, including their short half-life and instability. In this regard, this review study aims to
compare the influence of different PEGylation strategies on the quality of several blood products
like red blood cells (RBCs), platelets, plasma proteins, i.e., albumin, coagulation factor VIII, and
antibodies. The results indicated that conjugating succinimidyl carbonate methoxyPEG
(SCmPEG) to platelets could improve blood transfusion safety by preventing these cells from
being attached to low-load hidden bacteria in blood products. Moreover, coating of 20 kD succin- imidyl valerate (SVA)-mPEG to RBCs was able to extend the half-life and stability of these cells
during storage, as well as immune camouflage their surface antigens to prevent alloimmunisation.
As regards albumin products, PEGylation improved the albumin stability, especially during sterilization,
and there was a relationship between the molecular weight (MW) of PEG molecules and
the biological half-life of the conjugate. Although coating antibodies with short-chain PEG molecules
could enhance their stabilities, these modified proteins were cleared from the blood faster.
Also, branched PEG molecules enhanced the retention and shielding of the fragmented and
bispecific antibodies. Overall, the results of this literature review indicate that PEGylation can be
considered a useful tool for enhancing the stability and storage of blood components.
Aerobic Physical Exercise is Essential for Cardiac Autonomic Regulation
in Hypertensive Patients Undergoing Chronic Treatment with Renin-
Angiotensin System Inhibitors
Authors: de Paula Facioli Tábata , Philbois Stella Vieira , Tank Jens , Gastaldi Ada Clarice , Aguilar Bruno Augusto , da Veiga Oliveira Ana Catarine , Ferreira Lucas Dalvit , de  Souza Hugo Celso Dutra
Published: May 2023

Background:

Hypertension treatment with renin-angiotensin system inhibitors (RASi) presents
contradictions about the recovery of damage in cardiovascular autonomic modulation characterized
by reduced heart rate variability (HRV) and increased blood pressure variability (BPV). Conversely,
the association of RASi with physical training can influence achievements in cardiovascular autonomic
modulation.

Objective:

To investigate the effects of aerobic physical training on hemodynamics and cardiovascular
autonomic modulation in hypertensive volunteers untreated and treated with RASi.

Methods:

A non-randomized controlled trial in which 54 men (≅ 40-60 years old) with a history of hypertension
for >2 years were allocated in accordance with their characteristics into three groups: untreated
(Control; n=16), treated with type 1 angiotensin II (AT1) receptor blocker (losartan; n=21), and
treated with angiotensin-converting enzyme inhibitor (enalapril; n=17). All participants underwent hemodynamic,
metabolic, and cardiovascular autonomic evaluation using baroreflex sensitivity (BRS) and
spectral analysis of HRV and BPV, before and after 16 weeks of supervised aerobic physical training.

Results:

The volunteers treated with RASi had lower BPV and HRV, both in the supine position and in
the tilt test, with the losartan group having the lowest values. Aerobic physical training increased HRV
and BRS in all groups. However, the association of enalapril with physical training appears to be more
prominent.

Conclusion:

Long-term treatment with enalapril and losartan may harm the autonomic modulation of
HRV and BRS. Aerobic physical training is essential to promote positive adjustments in the autonomic
modulation of HRV and BRS in hypertensive patients treated with RASi, especially with enalapril.

Clinical Trial Registration No:

Brazilian Registry of Clinical Trials (RBR-8k2dsc).
Evaluation of Coronary Artery Diffuse Calcification Stenosis by Corrected
Coronary Opacification Difference
Authors: Shen Fangjie , Huang Jingfeng , Ding Qianjiang , Mao Quanliang , Ruan Xinzhong , Pan Yuning
Published: May 2023

Objectives:

The artifacts produced by calcification on coronary computed tomographic angiography (CCTA) have a great influence on the diagnosis of coronary stenosis. The purpose of this study is to investigate the value of corrected coronary opacification (CCO) difference in the diagnosis of stenosis in diffusely calcified coronary arteries (DCCAs).

Methods:

A total of 84 patients were enrolled. The CCO difference across the diffuse calcification was measured through CCTA. Coronary arteries were grouped according to the extent of stenosis obtained by invasive coronary angiography (ICA). The Kruskal-Wallis H test was used to compare the CCO differences between different groups and a receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of the CCO difference.

Results:

Among the 84 patients, 58 patients had one DCCA, 14 patients had 2 DCCAs, and 12 patients had 3 DCCAs. A total of 122 coronary arteries were examined, 16 showed no significant stenosis, 42 had <70% stenosis, and 64 had 70-99% stenosis. The median CCO differences among the 3 groups were 0.064, 0.117, and 0.176, respectively. There were significant differences between the group without stenosis and the group with 70-99% stenosis (H = -3.581, P = 0.001), and between the group with <70% stenosis and the group with 70-99% stenosis (H = -2.430, P = 0.045). The area under the ROC curve was 0.681 and the optimal cut-off point was 0.292. Taking the ICA results as the gold standard, the sensitivity and specificity for the diagnosis of ≥70% coronary stenosis with a cut-off point of 0.292 were 84.4% and 44.8%, respectively.

Conclusion:

CCO difference could be useful in the diagnosis of ≥70% severe coronary stenosis in DCCA. Through this non-invasive examination, the CCO difference could be a reference for clinical treatment.
Correlation of Diffusion weighted MR Imaging and ADC Values of Hepatic
Metastasis of Gastrointestinal Stromal and Gastroenteropancreatic
Neuroendocrine Tumors
Authors: Aydın Hasan , Metin Melike Ruşen , Kızılgöz Volkan
Published: May 2023

Background:

DWI and ADC-mapping was performed to analyze hepatic metastasis of GIST, GEP-NET.

Objective:

The objective of this study is to present hepatic metastasis of GIST and GEP-NET with Diffusion weighted MR imaging(DWI) and the Apparent diffusion coefficients (ADC) values of masses.

Methods:

18 GIST patients and 8 GEP-NET patients were examined retrospectively. 11 males and 6 females were present in GIST group, 7 males to 5 females were involved in GEP-NET group. 18 primary GIST and 10 hepatic metastasis of GIST, 8 original GEP-NET and 19 hepatic metastasis of GEP-NET; total 55 GIST and GEP-NET masses were analysed by ADC mapping. MR images were acquired by 1,5 T MR units (32 mT/min gradient strength- Achieva; Philips Healthcare, Best, Netherlands and 32 channel GE Signa GE-Wisconsin-USA); by using a 4-8 channel standard phased-array torso XL coil, all images were evaluated by an Abdominal MRI experienced radiologist. DWI was performed in the transverse plane by using spin-echo-planar imaging sequence.

Results:

No statistical differences were observed between GIST and GEP-NET patients according to age and gender variations. No significant statistical differences were observed according to the diameters and ADC values of GIST and GEP-NET patients. A significant statistical difference was observed between GIST and GEP-NET groups in terms of size of liver metastasis which was significantly higher in GIST patients. All three groups (GIST_Hep. MET, GEP-NET_Liver_Met and normal) were statistically differed according to ADC values. With the ROC curve analysis: Hepatic metastasis of GIST(n=10) and normal liver (n:47) had cut-off value for ADC: 0.925 under AUC: 0.939 with regard to ADC values and regarded 89.4 % Sensitivity, 100% Specificity, 100% PPV and 66.7% PPV. ROC curve of GEP NET_ Hepatic metastasis (n=19) group and normal liver (n:47) group presented cut-off value for ADC: 0.860 under AUC: 0.967 correlated to ADC values with 93.6 % sensitivity, 89.5% specificity, 95.7% PPV and 85% PPV.

Conclusion:

High cellular tumors resulted from liver metastasis of GIST and GEP-NET’s, and a positive correlation was observed between ADC values and cellularity/differentiation ratios of metastatic masses.
A Light, 3D UNet-based Architecture for Fully Automatic Segmentation of Prostate Lesions from T2-MRI Images
Authors: Bálint Zoltán , Coroama Larisa Gabriela , Diosan Laura , Telecan Teodora , Andras Iulia , Crisan Nicolae , Andreica Anca , Caraiani Cosmin , Lebovici Andrei , Boca Bianca
Published: May 2023

Introduction:

Prostate magnetic resonance imaging (MRI) has been recently integrated into the pathway of diagnosis of prostate cancer (PCa). However, the lack of an optimal contrast-to-noise ratio hinders automatic recognition of suspicious lesions, thus developing a solution for proper delimitation of the tumour and its separation from the healthy parenchyma, which is of primordial importance.

Method:

As a solution to this unmet medical need, we aimed to develop a decision support system based on artificial intelligence, which automatically segments the prostate and any suspect area from the 3D MRI images.
We assessed retrospective data from all patients diagnosed with PCa by MRI-US fusion prostate biopsy, who underwent prostate MRI in our department due to a clinical or biochemical suspicion of PCa (n=33). All examinations were performed using a 1.5 Tesla MRI scanner. All images were reviewed by two radiologists, who performed manual segmentation of the prostate and all lesions. A total of 145 augmented datasets were generated. The performance of our fully automated end-to-end segmentation model based on a 3D UNet architecture and trained in two learning scenarios (on 14 or 28 patient datasets) was evaluated by two loss functions.

Results:

Our model had an accuracy of over 90% for automatic segmentation of prostate and PCa nodules, as compared to manual segmentation. We have shown low complexity networks, UNet architecture with less than five layers, as feasible and to show good performance for automatic 3D MRI image segmentation. A larger training dataset could further improve the results.

Conclusion:

Therefore, herein, we propose a less complex network, a slim 3D UNet with superior performance, being faster than the original five-layer UNet architecture.
A New Buffer for Gallium-68 Labeling Suitable for use in Nuclear Medicine;
Triethanolamine (TEA)
Authors: Uğur Ayşe , Yaylali Olga , Yüksel Doğangün
Published: May 2023

Background:

Radiopharmaceuticals labeled with [68Ga] from positron emission tomography
(PET) radionuclides are utilized in nuclear medicine for non-invasive in vivo molecular imaging.
Buffer solutions for radiolabeling play an important role as choosing the right buffer for the
reaction helps to obtain high yield radiopharmaceuticals. Zwitterionic organic buffer 4-(2-
hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), sodium acetate (CH3COONa), sodium
bicarbonate (NaHCO3) buffers are widely used for labeling of peptides with [68Ga]Cl3. They can
be used for peptide labelings with the acidic [68Ga]Cl3 precursor of triethanolammonium (TEA)
buffer. The cost and toxicity of TAE buffer are relatively low.

Method:

For [68Ga]GaPSMA-HBED-CC and [68Ga]GaDOTA-TATE labeling, the effectiveness of
TEA buffer without chemical impurities in radiolabeling reactions and QC parameters in successful
labeling was investigated.

Results:

The method used to label [68Ga]Cl3 with PSMA-HBED-CC peptide in the presence of
TEA buffer was successful when applied at room temperature. High purity radiosynthesis suitable
for clinical use was performed to obtain DOTA-TATE peptide with the addition of 363K temperature
and radical scavenger. Quality control tests with R-HPLC have shown that this method is
suitable for clinical use.

Conclusion:

We present an alternative procedure for labeling PSMA-HBED-CC and DOTATATE
peptides with [68GaCl3] to obtain high radioactive doses of final radiopharmaceutical products
used in nuclear medicine clinical applications. We have provided a quality-controlled final
product that can be used in clinical diagnostic procedures. With the use of an alternative buffer,
these methods could be adapted to semi-automatic or automated modules routinely used in nuclear
medicine laboratories to label [68Ga]-based radiopharmaceuticals.
Повышение радиационной стойкости интегральных схем на основе биполярных транзисторов обработкой в водородной электронно циклотронно резонансной плазме и геттерированием Si-пластин
Authors: Полушкин Е.А. , Нефедьев С.В. , Солтанович О.А. , Ковальчук А.В. , Шаповал С.Ю.
Published: May 2023

We demonstrate significant improvement of the radiation immunity of the integrated circuits based on silicon bipolar transistors. Strong decrease of the current gain degradation and significant yield improvement after high-energy gamma irradiation are both shown. This was achieved by development of efficient hydrogenation process for the silicon bulk and the surface dielectric layer using electron cyclotron resonance (ECR) plasma, as well as implementation of effective Si-plate gettering option.
Nuevas variedades de cacao TCS (Theobroma Corpoica La Suiza ) 13 y 19
Authors: Agudelo Castañeda Genaro Andrés , Palencia Calderón Gildardo Efraín , Antolinez Sandoval Eduar Yovani , Báez Daza Eliana Yadira
Published: May 2023

En el cultivo de cacao se pueden lograr incrementos significativos en productividad a través de dos vías: la primera, consiste en aplicar buenas prácticas agronómicas para que el cultivo pueda expresar su máximo potencial productivo; y, la segunda, mediante el mejoramiento genético, es decir, emplear adecuados sistemas de selección, hibridación y multiplicación para obtener materiales más productivos. De esta manera, el cultivo de cacao se puede constituir en una fuente rentable de ingresos para los productores; sin embargo, es necesario utilizar materiales genéticos provenientes de variedades seleccionadas e identificadas por su potencial productivo, con características deseables en calidad y expresión genética manifestada a diferentes ambientes (Mejía, 2000). Por lo anterior, la cacaocultura colombiana requiere nuevos materiales genéticos adaptados a las diferentes regiones agroecológicas para aumentar los rendimientos y la rentabilidad del cultivo como estrategia para atender la demanda de nuevas siembras y rehabilitación de plantaciones comerciales.
Alimentación de la Colmena
Authors: Vásquez Romero Rodrigo Efrén , Cepeda Granados Mónica
Published: May 2023

Las abejas al igual que todos los seres vivos requieren de una dieta balanceada que les permita expresar su protencial genético, por lo cual es necesario garantizar la disponibilidad de nutrientes para ellas, ya sea de forma natural o artificial.
Balance social 2018
Authors:   ‎‎Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: May 2023

En los últimos años, nos propusimos un reto en la Corporación Colombiana de Investigación Agropecuaria: entregar anualmente a la sociedad un Balance Social que evidencie el retorno social generado en cumplimiento de nuestra misión institucional. Así, en el 2017 presentamos la primera versión y ahora lo hacemos por segundo año consecutivo. El Balance Social nos permite mostrar de manera transparente el fruto de nuestras acciones y extraer importantes aprendizajes para orientar nuestra agenda de investigación y transferencia, con el ánimo de propiciar cada vez mayores cambios positivos en el sector agropecuario colombiano.
Evaluación técnico - económica de opciones de manejo del ácaro rojo (Tetranychus ludeni) en el cultivo de berenjena en el valle medio del Sinú, Córdoba - Colombia
Authors: Rodríguez Pinto María del Valle , Grandett Martínez Liliana María , Martínez Reina Antonio María , Tordecilla Zumaqué Lilibet , Sierra Monroy Janeth Alexandra
Published: May 2023

La berenjena (Solanum melongena L.) es una hortaliza importante del sector productivo en el valle medio del Sinú, que es afectada por el ácaro rojo T. ludeni que causa daños al reducir el área fotosintética, y la producción de frutos. El objetivo de esta investigación fue evaluar de acuerdo a niveles de infestación de ácaros con aplicaciones de acaricidas, el efecto en rendimiento en un material de berenjena menos resistente al daño del ácaro.
Acceptance of a Web-Based Intervention in Individuals Who Committed Sexual Offenses Against Children: Cross-Sectional Study (Preprint)
Authors: Schröder Sonja , Buntrock Claudia , Neumann Louisa , Müller Jürgen L , Fromberger Peter
Published: May 2023

BACKGROUND

Individuals who have committed sexual offenses against children often have difficulties finding treatment, despite its potential effectiveness. Although the development of web-based interventions could enhance therapeutic supply, up to now the acceptance thereof among this target group is unknown.

OBJECTIVE

For the first time, this study assesses the acceptance of a web-based intervention among individuals who committed sexual offenses against children and analyzes variables that predict acceptance. Following the Unified Theory of Acceptance and Use of Technology (UTAUT), it is assumed that acceptance of web-based interventions in individuals who have committed sexual offenses against children follows the same mechanisms as for individuals in general psychiatry.

METHODS

This cross-sectional study is based on the data from an ongoing clinical trial (@myTabu) evaluating the effectiveness of a web-based intervention in individuals who committed sexual offenses against children (N=113). Acceptance level was measured using a questionnaire based on the UTAUT and modified for the target group. Furthermore, predictors of acceptance from the UTAUT (performance expectancy, effort expectancy, and social influence [SI]), attitudes toward web-based interventions, and internet anxiety were assessed at baseline.

RESULTS

Most participants (61.1%, 69/113), reported high acceptance, while 36.3% (41/113) of them indicated moderate acceptance, and 2.7% (3/113) of them expressed low acceptance. In a linear regression model, the predictors explained 41.2% of the variance (F11,101=9.055; P=.01). Attitudes toward web-based interventions (B=0.398, 95% CI 0.16-0.64; P=.001) and SI (B=0.183, 95% CI 0.03-0.38; P=.04) significantly predicted acceptance. Post hoc explorative analysis showed that the participants’ belief that people close to them would recommend the use of a web-based intervention is a predictor of acceptance. In contrast, the belief that their community supervisor would recommend the use thereof was not predictive in this respect.

CONCLUSIONS

For the participants of this study, we identified high acceptance of web-based interventions for the majority of participants. SI and the participants’ attitudes toward web-based interventions were important in predicting acceptance.

CLINICALTRIAL

German Clinical Trial Registration (DRKS, Deutsches Register Klinischer Studien) DRKS 00021256; https://drks.de/search/de/trial/DRKS00021256
Survey of the Impact of Decision Support in Preoperative Management of Anemia (i-Anemia): Survey Study (Preprint)
Authors: Mignanelli Gaëtan , Boyer Richard , Bonifas Nicolas , Rineau Emmanuel , Moussali Yassine , Le Guen Morgan
Published: May 2023

BACKGROUND

Major surgery on patients with anemia has demonstrated an increased risk of perioperative blood transfusions and postoperative morbidity and mortality. Recent studies have shown that integrating preoperative anemia treatment as a component of perioperative blood management may reduce blood product utilization and improve outcomes in both cardiac and noncardiac surgery. However, outpatient management of anemia falls outside of daily practice for most anesthesiologists and is probably weakly understood.

OBJECTIVE

We conducted a simulated case survey with anesthesiologists to accomplish the following aims: (1) evaluate the baseline knowledge of the preoperative optimization of anemia and (2) determine the impact of real-time clinical decision support on anemia management.

METHODS

We sent a digital survey (i-Anemia) to members of the French Society of Anaesthesia and Critical Care. The i-Anemia survey contained 7 simulated case vignettes, each describing a patient’s brief clinical history and containing up to 3 multiple-choice questions related to preoperative anemia management (12 questions in total). The cases concerned potential situations of preoperative anemia and were created and validated with a committee of patient blood management experts. Correct answers were determined by the current guidelines or by expert consensus. Eligible participants were randomly assigned to control or decision support groups. In the decision support group, the primary outcome measured was the correct response rate.

RESULTS

Overall, 1123 participants were enrolled and randomly divided into control (n=568) and decision support (n=555) groups. Among them, 763 participants fully responded to the survey. We obtained a complete response rate of 65.6% (n=364) in the group receiving cognitive aid and 70.2% (n=399) in the group without assistance. The mean duration of response was 10.2 (SD 6.8) minutes versus 7.8 (SD 5) minutes for the decision support and control groups, respectively (P<.001). The score significantly improved with cognitive aid (mean 10.3 out of 12, SD 2.1) in comparison to standard care (mean 6.2 out of 12, SD 2.1; P<.001).

CONCLUSIONS

Management strategies to optimize preoperative anemia are not fully known and applied by anesthesiologists in daily practice despite their clinical importance. However, adding a decision support tool can significantly improve patient care by reminding practitioners of current recommendations.
The Proof and Development of the Right to Be Forgotten in Civil Code
Authors: Li MoFei
Published: May 2023

Contemporary Chinese rights of personality law are in a period of perfection. The Personal Rights section of the Civil Code provides the ideological basis of law for other legislation on the rights of personality in China, and the newly released Personal Information Protection Law provides relevant provisions for the privacy issues involved in personal information. The legislation related to personality rights in China should respond to the needs of people’s personality rights in the Internet era and introduce laws to some rights that have emerged with the development of the Internet. In other words, based on confirming the general personality rights and personal information protection, we should protect the emerging rights such as “the right to be forgotten”. In this regard, based on the existing judicial and legislative practices, it is necessary to argue that the right to be forgotten is an independent form of right and to explore the legislative way forward for the right to be forgotten, to contribute to the effective protection of personality rights and personal information.
REVIEW OF THE ENVIRONMENTAL SITUATION IN THE VOLGA FEDERAL DISTRICT (BASED ON STATISTICAL DATA ON EMISSIONS OF POLLUTANTS TO AT-MOSPHERIC AIR AND WATER)
Authors: Sokolova N. G. , Kiseleva N. A.
Published: May 2023

Economic growth is the main task of any state. It involves increasing the rate of production, which has a negative impact on nature. The paper examines the ecological situation in the constituent entities of the Volga Federal District on the basis of statistical data on emissions of pollutants into the air and water. This region is one of the leaders in terms of industrial production, therefore the constant problems of air pollution are relevant for the territory and require constant intervention from the state and the whole society. Environmental problems have their consequences, they affect not only nature, but also the socio-economic sphere, which in turn is directly related to the investment attractiveness of the region. The investment attractiveness of the region is an important resource that is necessary for economic growth, in many respects it is he who is an indicator of the state of the regional economy and the effectiveness of the environmental and economic management of the regional government. The article not only analyzes the ecological situation of the region and its subjects, but also substantiates the need for further study of the problems in order to identify regions in which the practices of environmental and economic management have developed, with the aim of their application in subjects with environmental problems, which will allow attracting investors in the future and improve social and economic development.
FORMATION OF ENTREPRENEURIAL ECOSYSTEMS IN THE DEFENSE COMPLEX AS A WAY TO A SOFT CONVERSION
Authors: Zimin S. D.
Published: May 2023

The paper describes the current state of the military-industrial complex (hereinafter referred to as the defense industry complex) in Russia and the tendencies of its change at the present stage. Possible ways of development of enterprises of the defense industry of the Russian Federation on the path of conversion of the defense order are discussed. Conversion in this case is considered as a particular type of business diversification. The advantages and disadvantages of such diversification are described for the enterprise itself, which implements such a strategy. As a new way of development of defense industry enterprises in the context of the conversion of defense orders, it is proposed to build their own entrepreneurial ecosystems. An entrepreneurial ecosystem is understood as “a dynamically and jointly developing community, consisting of a variety of actors creating and receiving new content in the process of both interaction and competition”. This concept is useful specifically for defense industry enterprises at the present stage, since it offers a variant of their “soft” conversion and is especially suitable for large and medium-sized defense enterprises. The advantages and disadvantages of two possible ways of converting a defense order and switching to civilian production for defense industry enterprises are substantiated: contract production at defense facilities, or own developments. The differences in the economic component of each of the approaches are investigated and a conclusion is drawn.
INCREASING BUSINESS EFFICIENCY BASED ON A BALANCED PERFORMANCE SYSTEM
Authors: Domaskin V. A. , Sokolova I. N.
Published: May 2023

A balanced system of indicators is an important component of the implementation of the company's strategy. Currently, for the successful functioning of enterprises, it is not enough to focus only on the final financial results of activities, an integrated approach is important, the essence of which is to take into account all the constituent components, such as resources, business processes, finance, etc. The use of the balanced scorecard methodology allows us to take into account all these indicators and contributes to improving the business efficiency and competitiveness of the enterprise. The article presents the concept of a balanced system of indicators, goals, tasks and functions, discusses the basic schemes of a system of balanced indicators in the main areas, provides the benefits that can be obtained from the introduction of a system of balanced indicators. Also, much attention is paid to the development of a phased implementation of a balanced system of indicators, business performance indicators in the main areas: customers, finance, business processes, personnel. When developing a balanced system of indicators, it is necessary to take into account the factors that have a positive or negative impact, which ultimately contributes to the implementation of the strategic goals of the organization. The introduction of a balanced scorecard is a complex and time-consuming process that requires high knowledge from the top management of the organization. In order for the implementation efficiency to be the highest, it is important to provide for all possible mistakes that can be made at the stage of system implementation.
WAYS OF DEVELOPMENT OF INVESTMENT LIFE INSURANCE IN RUSSIA
Authors: Zabbarova M. D. , Firsova S. N.
Published: May 2023

The declining state of the financial market in recent years has strengthened the population's distrust of various financial instruments. Many continue to keep money in cash and in bank deposits, but this does not generate income, or it only covers inflation. The state strives to create new investment solutions that will contribute to attracting money from the population to the economy. Investment life insurance is a significant factor in the development of the national economy, since insurers' funds are directed to investments in government securities and shares and bonds of Russian companies. The mandatory risks included in the ILI agreement are the survival of the insured person, as well as his death. The sum insured upon the occurrence of the risk is paid in 100% of the insurance premiums paid, plus the investment income accumulated by the time of the death of the insured is charged. The article discusses the main problems of reducing the demand for investment life insurance, as well as the ways of its development. Including the main problem with not receiving income from investments. It is proposed to introduce a minimum rate of return, which will have a positive effect on the credit of trust of the insurance company.
IMPROVEMENT OF THE SYSTEM OF MOTIVATION OF EMPLOYEES OF A TRADING COMPANY
Authors: Sokolova I. N. , Lobanova G. A.
Published: May 2023

The article is relevant, since the interest of workers in the results of labor is the basis for the successful development of domestic enterprises and business in general. At the same time, the improvement and enhancement of trade processes are taking an increasing place in the economy of any country. In the context of the development of a competitive market, the motivation of sales personnel is the basis for the growth of labor productivity and the achievement of high performance indicators both for the trading enterprise itself, and for the manufacturer and, of course, for the consumer. Correctly developed measures to improve the motivation system of employees of a trading enterprise, as a result, will increase sales revenue and other performance indicators. The article presents the basic principles of motivating employees of the enterprise, investigates the motivational processes of LLC “Arkaim”, on the basis of which changes are proposed in the system of bonuses to employees of the enterprise for the high-quality performance of duties. It was revealed that in LLC “Arkaim” not enough attention is paid to an important motivating factor for increasing the productivity of employees - training of personnel. The main stages of development of the training system at the enterprise are proposed. The budget for staff training for the current year has been formed. The results of the introduction of the new bonus program testify to the effectiveness of the developed measures to stimulate the employees of the trade enterprise.
Educational Record Authentication Using Decentralized Consortium Blockchain Technology
Authors: Bawane Deep H. , Sudke Yogesh S. , Pore Prof. Yogita N.
Published: May 2023

Abstract: The current facilities provided by educational institutes across the global to authenticate educational records use centralized approach of maintaining a server. This introduces two key challenges. One is to provide sharing and browsing facilities even when there is server maintenance. The other is to prove the authenticity of the records. The first challenge may be resolved using cloud-based techniques. To address the second challenge, we propose a consortium blockchain based solution. By using off-chain storage for record update and management, third party modification to any valuable data can be known. The nodes in the decentralized peer-to-peer network are servers handled by recognized educational institutes which may be autonomous or affiliated. Using cryptography, the hash information of records is stored on a decentralized blockchain. This enables a student or a third party to quickly verify his/her marks by verifying hashes of them from a reputed peer-to-peer network
Chromosome Classification Using Deep Learning Technique
Authors: Wakchaure Sakshi
Published: May 2023

Abstract: Automated chromosome classification is a critical task in cytogenetics and has been traditionally performed manually. Recent advancements in image processing and machine learning have opened new avenues for automated chromosome classification. This paper presents a novel method for straightening and classifying chromosomes, utilizing a blend of imageprocessing techniques and a convolutional neural network (CNN) algorithm. The proposed approach involves pre-processing chromosome images, which includes straightening them to eliminate any curvature caused by their natural shape and extracting features with the aid of a CNN. The design of the method allows for the training and testing of images, facilitating the prediction of chromosomal abnormalities with high accuracy. The performance of the method was evaluated using a dataset of chromosome images, demonstrating exceptional accuracy and robustness. The proposed approach was evaluated using publicly available datasets of human chromosomes and achieved an accuracy of 93% without the straightening of chromosomes and 96% after the straightening of chromosomes. This method has the potential to be applied in cytogenetics and medical diagnosis, where precise and efficient chromosome classification is vital, and the ability to straighten chromosomes can enhance the accuracy of the analysis.
Social Sphere: A MERN Stack Social Media App
Authors: Malik Asif
Published: May 2023

Abstract: In today's ever-evolving tech industry, there is a significant surge in the demand for full-stack developers. Reports suggest that skilled professionals in this field, particularly in the United States, can expect remarkable average profits, with figures reaching as high as $110,770, according to Real. A full-stack developer is an individual who possesses the technical expertise to handle both the front-end and back-end aspects of dynamic websites and internet-based applications. Web development often revolves around frameworks like the LAMP stack (Linux, Apache, MySQL, PHP/Perl) and Java (Java EE, Spring), which incorporate a combination of programming languages. Additionally, JavaScript plays a crucial role in enhancing web experiences, enabling developers to leverage the MERN stack (MongoDB, Express.js, React.js, and Node.js). This comprehensive technology stack empowers developers to effectively address user interface requirements and server-side operations
Identification of Type of Metals by Using Heat Transfer Rate
Authors: Karthikeyan V.
Published: May 2023

Abstract: Metals are advances in manufacturing processes which is the industrial revolution. It is very important to accurately identify types of metal when working with metal materials, and this is particularly important in maintenance welding. Metals with higher carbon content are sensitive to hot-cracking and hardening, which can result in poor ductility for welding projects. If it want to be simply identify a piece of scrap metal, it can be done by evaluating its colour, weight and composition. The common ways to identify metal is surface appearance, spark test, chip test, magnet test, hardness test. Project is to identifying metals based on their heat rate from one end to another end through a instrument automatically. This is because of electron arrangement in them.
EVs Lithium-ion Battery Heating Analysis and Monitoring
Authors: Irkate Swapnil
Published: May 2023

Abstract: We are rapidly moving towards the future and EV’s are going to be an important part of it. In this paper we are going to find out the reason why those electric vehicles are catching fire, how short-circuit in internal circuits due to variation in current, voltage can cause increase in temperature. Basically, there are two parameters are cause the heating issues in the battery i.e., internal and external parameters of the battery. So, in the proposed work, we have done with the sub parameters of the above two mentioned parameters observation that how they cause a temperature increase in battery.
Melanoma Skin Cancer Detection using Image Processing
Authors: Pawar Atharva
Published: May 2023

Abstract: Early detection of melanoma skin cancer is crucial for effective treatment. Melanoma is considered the most dangerous form of skin cancer due to its higher likelihood of spreading to other parts of the body if not diagnosed and treated promptly. To address this challenge, non-invasive medical computer vision and medical image processing techniques have become increasingly important in clinical diagnosis of various diseases, including melanoma. These techniques offer automated image analysis tools that enable accurate and rapid evaluation of skin lesions.To assess the severity of the lesions, a total dermo copy score was calculated based on the extracted features. Finally, classification was carried out using a convolutional neural network (CNN) model. The results of the study demonstrated a high classification accuracy of 96.5%, indicating the effectiveness of the proposed approach in accurately identifying melanoma skin cancer.
Analisis Penerapan Model Pembelajaran Project Based Learning Berbasis Content Video Pada Pembelajaran Konsep Dasar Sains Mahasiswa
Authors: Setyo Retno Raras
Published: May 2023

The project-Based Learning (PjBL) model is a learning model that identifies, through research, real-world problems, from local to global, and develops solutions using evidence to support claims, offers solutions using multimodal approach to a presentation based on a set of 21st century skills. This research aims to analyze the application of the Project-Based Learning (PjBL) model based on video content in learning the basic concepts of science for students. This descriptive research uses phenomenological approach, which is a study that describes the meaning of individuals regarding their experience of a concept or phenomenon. The data collection techniques are conducted through observation, interviews, and documentation. The interactive analysis model from Matthew B Miles and Hubermen is used for data analysis. The model technically consists of 4 (four) main phases: data collection, data reduction or simplification, data presentation, and conclusion or verification. The analysis results show that the implementation of the PjBl learning model is effective, as seen from the students activities which closely complies to the steps. In addition, students are more creative, active, and innovative in learning science and show more confidence. Students are also more independent in learning about the topic they are interested in and becoming tutors for their friends
Impact Of Massive Open Online Course (Mooc) As Best Practice In Indonesia Medan Marelan District Elementary School
Authors: Sari Rizka Purnama , Dahnial Irfan
Published: May 2023

This study aims to determine the response of elementary school students to online learning that was carried out during the Covid-19 pandemic. The study used a limited survey conducted for the elementary school level with a total of 32 respondents (1 class). This survey is directed to find out the impact of student learning in using the Massive Open Online Course (MOOC), in this case, the use of the website which has been developed to compare learning where students freely express their thoughts in written form (not a close-ended option). In this case, the research instrument that was used is in the form of a questionnaire that is used to find out students’ opinions about internet-based learning that they do during the COVID-19 pandemic. The results of the analysis of the 25 statements in the questionnaire were declared valid, all based on data processing with the help of SPSS for Windows version 25.0. The statement in the questionnaire is said to be valid because of the sig < 0.05, then the questionnaire is declared valid and reliable with the t-count result of 0.874 > 0.05. The results of the study describe how the impact of MOOC as the best practice has the potential to affect students’ attitudes, self-confidence, and independence. Research conducted in the classroom shows that learners consciously construct a unique learner culture within MOOCs. By viewing MOOC as a dynamic global social learning culture, we offer a new lens for learning and learning designers to use in developing, delivering, and facilitating MOOC learning.
Penerimaan Teknologi E-Learning SiPeDar Dengan Menggunakan Technology of Acceptance Model (TAM)
Authors: Ardhian Trio , Najib Khotim Hanifudin , Nofrida Eka Ridha , Trisniawati
Published: May 2023

SiPeDar is an e-learning platform developed by UST to facilitate learning from the campus academic community. The application of Information Technology is always related to user acceptance. Therefore, the purpose of this study is to obtain empirical evidence related to the acceptance of SiPeDar technology using the Theory of Acceptance Model (TAM) framework with the construct of perceived ease of use, perceived usefulness, attitude toward using, and acceptance of e-learning system (acceptance of e-learning system). The sample of this study was 77 students from UST Yogyakarta PGSD students who were randomly selected. The data collection technique employed a questionnaire distributed through Gform. The data analysis technique used is quantitative descriptive data analysis using the SPSS program. The results showed that the perceived ease of use of SipeDar and students' perceived usefulness towards SiPeDar were good. The students' attitude towards using SiPedar shows a reasonably good assessment category. SiPeDar's actual system usage shows a high level of usage among students.
Driven-dissipative topological phases in parametric resonator arrays
Authors: Gómez-León Álvaro , Ramos Tomás , González-Tudela Alejandro , Porras Diego
Published: May 2023

We study the phenomena of topological amplification in arrays of parametric oscillators. We find two phases of topological amplification, both with directional transport and exponential gain with the number of sites, and one of them featuring squeezing. We also find a topologically trivial phase with zero-energy modes which produces amplification but lacks the robust topological protection of the others. We characterize the resilience to disorder of the different phases and their stability, gain, and noise-to-signal ratio. Finally, we discuss their experimental implementation with state-of-the-art techniques.
Exact and efficient Lanczos method on a quantum computer
Authors: Kirby William , Motta Mario , Mezzacapo Antonio
Published: May 2023

We present an algorithm that uses block encoding on a quantum computer to exactly construct a Krylov space, which can be used as the basis for the Lanczos method to estimate extremal eigenvalues of Hamiltonians. While the classical Lanczos method has exponential cost in the system size to represent the Krylov states for quantum systems, our efficient quantum algorithm achieves this in polynomial time and memory. The construction presented is exact in the sense that the resulting Krylov space is identical to that of the Lanczos method, so the only approximation with respect to the exact method is due to finite sample noise. This is possible because, unlike previous quantum Krylov methods, our algorithm does not require simulating real or imaginary time evolution. We provide an explicit error bound for the resulting ground state energy estimate in the presence of noise. For our method to be successful efficiently, the only requirement on the input problem is that the overlap of the initial state with the true ground state must be Ω(1/poly(n)) for n qubits.
Tradução do prefácio dos elementos de geometria de Euclides de Megara por John Dee
Authors: Oliveira Gabriela Raspanti , Sapunaru Raquel Anna
Published: May 2023

Esta tradução foi feita a partir do texto The Project Gutenberg eBook of the Mathematical Preface To Elements of Geometry of Euclid of Megara by John Dee. Esse e-book é para uso geral, em qualquer lugar sem custos e sem restrições. A ideia de fazer a tradução do Prefácio Matemático dos Elementos de Geometria de Euclides de Megara surgiu em 2011, com o projeto “Euclides para os Vales”. O referido projeto teve como objetivo recuperar o ensino da geometria nas escolas públicas de Diamantina – MG, treinando professores e alunos. O prefácio dava uma visão totalmente inusitada do que seriam os Elementos e não foi diretamente utilizado. Foi uma leitura intrigante, cheia de surpresas e armadilhas literárias. De algum modo, eu sabia que retornaria a ele algum dia... Assim, cheguei a esse maravilhoso prefácio, cheio de matemática e mistério.