bluuebunny/crossref_metadata_2025 huggingface dataset:
Calcium oscillations in Mesenchymal Stem Cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation?
Authors: Vallet Leslie A , Marina SANCHEZ PETIDIER , Romain FERNANDES , Nataliia NAUMOVA , Caterina MERLA , Claudia CONSALES , Giorgia INNAMORATI , Andre Franck M , Mir Lluis M.
Published: January 2025

Background Mesenchymal stem cells (MSCs) have been shown to exhibit Ca2+ oscillations under regular culture conditions. Ca2+ oscillations are known to encode important information in their frequencies as well as in their amplitudes, and ultimately to control many cellular processes such as proliferation and differentiation. These Ca2+ oscillations are modified in cells differentiated from MSCs, especially in their frequencies. Understanding the regulation of the Ca2+ oscillations in MSCs, either during proliferation or differentiation, is a necessary step in the attractive perspective of controlling Ca2+ signaling to influence cell fate. Previous studies have shown that the application of a low amplitude direct current electric field, which decreased the frequency of Ca2+ oscillations in MSCs undergoing osteogenic differentiation, had an impact on the differentiation process.Methods Using fluorescent microscopy we evaluated the evolution of Ca2+ oscillations throughout the adipogenic and osteogenic differentiation processes. Then, using electrical stimulation with microsecond pulsed electric fields (µsPEFs), we manipulated the frequency of Ca2+ oscillations in MSCs and measured its consequences on cell growth.Results Although the evolution of the Ca2+ oscillation frequencies at the beginning of the differentiation processes was different between the adipogenic and osteogenic differentiations, we observed common features in the terminal stages of differentiation. The common features included a progressive decrease in the Ca2+ oscillation frequencies, before their complete arrest as the differentiations were arriving to their term. A relationship between the frequency of Ca2+ oscillations and the progression of the cell cycle, more precisely the G1 phase, could explain the frequencies of Ca2+ oscillations observed during proliferation and along the differentiations. We hypothesized that increasing the frequency of Ca2+ oscillations would promote proliferation, while decreasing it would promote differentiation under differentiating conditions. Using electrical stimulation with µsPEFs, we manipulated the frequency of Ca2+ oscillations in MSCs and their increase promoted cell proliferation.Conclusions The cell fate of MSCs, in particular cell growth, can be controlled by manipulating the frequency of Ca2+ oscillations. We propose hypotheses on the actors that could regulate the evolution of the Ca2+ oscillation frequency along the differentiation processes, based on data available in the literature.
IL-1 signaling enrichment in inflammatory skin disease loci with higher risk allele frequencies in African ancestry
Authors: Tsoi Lam , Dong Yumeng , Patrick Matthew , Sarkar Mrinal , Zhang Haihan , Bogle Rachael , Zhang Zhaolin , Dand Nick , Paulsen Michelle , Ljungman Mats , Betz Regina C. , Petukhova Lynn , Christiano Angela , Simpson Michael , Modlin Robert , Khanna Dinesh , Barker jonathan , Budunova Irina , Gharaee-Kermani Mehrnaz , Billi Allison , Elder James , Kahlenberg J. Michelle , Gudjonsson Johann
Published: January 2025

Inflammatory skin diseases (ISDs) exhibit varying prevalence across different ancestry background and geographical regions. Genetic research for complex ISDs has predominantly centered on European Ancestry (EurA) populations and genetic effects on immune cell responses but generally failed to consider contributions from other cell types in skin. Here, we utilized 273 genetic signals from seven different ISDs: acne, alopecia areata (AA), atopic dermatitis (AD), psoriasis, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and vitiligo, to demonstrate enriched IL1 signaling in keratinocytes, particularly in signals with higher risk allele frequencies in the African ancestry. Using a combination of ATAC-seq, Bru-seq, and promoter capture Hi-C, we revealed potential regulatory mechanisms of the acne locus on chromosome 2q13. We further demonstrated differential responses in keratinocytes upon IL1β stimulation, including the pro-inflammatory mediators CCL5, IL36G, and CXCL8. Taken together, our findings highlight IL1 signaling in epidermal keratinocytes as a contributor to ancestry-related differences in ISDs. CAPSULE SUMMARY: ISD-associated loci highlight IL-1 signaling enrichment in African ancestry. Multi-omics reveals regulatory mechanisms at 2q13 for acne.
Mycobacterium abscessus Urinary Tract Infection Associated with Urinary Catheter Use: A Case Report
Authors: Alanazi Majed , Alsaber Naif , Alharbi Nasser , Alissa Munirah , Alaskar Majed
Published: January 2025

Urinary tract infections (UTIs) are a common health issue, especially among the elderly. While most UTIs are caused by typical bacterial pathogens, infections with atypical organisms like Mycobacterium abscessus, a non-tuberculous mycobacterium (NTM), are exceedingly rare. This case report details one such case of a 78-year-old woman with a complex medical history who developed a persistent UTI due to M. abscessus associated with urinary catheter use. Despite multiple courses of antibiotics, her symptomatology persisted, leading to the isolation of M. abscessus via acid-fast bacilli (AFB) culture. This case makes evident the challenges associated with diagnosing and managing NTM UTIs, especially given the organism’s resistance to standard treatments and the patient’s multiple comorbidities. A comprehensive review of relevant literature is provided, further delineating the rarity of genitourinary M. abscessus infections and the need for specialized diagnostic and therapeutic approaches.
Spatiotemporal faunal connectivity across global seafloors
Authors: O'Hara Timothy , Hugall Andrew , Haines Margaret , Weber Alexandra Anh-Thu , Eichsteller Angelina , Brogger Martin , Eléaume Marc , Fujita Toshihiko , Kongsrud Jon , Arbizu Pedro Martinez , Mills V , Olbers Jennifer , Paulay Gustav , Ramil Fran , Samadi Sarah , Sands Chester , Sellanes javier , Solis-Marin Francisco , Moussalli Adnan
Published: January 2025

Our knowledge of biogeographic patterns and processes in the deep sea has been limited by the lack of integrated datasets that cover its vast extent. Here we analyse a new global dataset of genomic DNA sequences, spanning an entire taxonomic class of benthic invertebrates (Ophiuroidea), to obtain a broad understanding of phylogenetic divergence and biotic movement across all oceans, from coastal margins down to the abyssal plains. We show that regional faunas on the continental shelf are phylogenetically divergent, particularly at temperate and tropical latitudes. In contrast, assemblages in the deep sea are much more connected. Many temperate deep-sea lineages have achieved distribution ranges across the planet, including over the Quaternary period. A close relationship exists between deep-sea faunas of the North Atlantic and Southern Australia, on the opposite sides of the globe. Bathymetric interchange is not only reliant on vertical migration through isothermal polar waters but also occurs across the thermal depth gradients of tropical regions. The connected nature of deep-sea life should be an important consideration in marine conservation assessments.
Spillover effects from the divorce of peer parents: Evidence from student academic achievements in China
Authors: Chen Boou , Zhao Chunkai , Liu Xiaoyu
Published: January 2025

Although the impact of parental divorce on children’s human capital development has received sufficient attention from scholars, little has been paid to the potential spillovers. Based on a quasi-natural experiment with random student-classroom assignment in secondary schools in China, we aimed to explore whether the peer parental divorce (PPD) can have a negative spillover effect on students’ academic achievements in a class. The results show that the PPD negatively impacted students’ test scores and cognitive abilities, but this adverse effect is not reflected in non-cognitive abilities. Mechanism analyses suggested that this spillover effect may be explained by the decline in parental expectations, development of students’ negative expectations and learning behaviors, and drop in teachers’ efforts and enthusiasm. Moreover, we found that the negative spillovers of PPD are more pronounced for urban children, only children, and non-poor children. Furthermore, supports from teachers, parents, and friends is expected to mitigate this adverse spillover effects. Our study reveals the spillovers from parental divorce, suggesting that the negative effects of divorce on human capital are not confined within the family. These findings further provide some insights into mitigating the human capital loss from divorce.
The impact of population-wide lifestyle modifications on improving life expectancy in the Chinese population: a simulation study
Authors: Lv Jun , Sun Qiufen , Zhao Liyun , Yang Yuxiang , Ding Yinqi , Yu Canqing , Sun Dianjianyi , Pang Yuanjie , Pei Pei , Yang Ling , Chen Yiping , Du Huaidong , Du Ranran , Barnard Maxim , Chen Junshi , Chen Zhengming , Yu Dongmei , Li Liming
Published: January 2025

Background Despite considerable population-wide measures to promote the Chinese population’s healthy lifestyle, it is uncertain how much life expectancy (LE) would improve under current and greater policy targets on lifestyle behaviours.Methods We developed 5-year sex-specific all-cause mortality risk prediction models using data from the China Kadoorie Biobank (CKB). Based on nationally representative survey data from China Nutrition and Health Surveillance (2015), we simulated changes in the prevalence of four lifestyle factors: smoking status, alcohol consumption, total physical activity level, and dietary habits (daily intake amount of fresh fruits and fish/seafood). The LE for each hypothetical lifestyle intervention scenario was calculated based on the age-specific probability of death obtained from the risk prediction models.Results During a median follow-up of 12.1 years, the CKB documented 31,956 deaths in men and 24,593 deaths in women. The prediction models for men and women demonstrated good discrimination, with the overall area under the receiver-operating characteristic curve of 0.800 for men and 0.808 for women. In the ideal scenario of all lifestyle factors, that is, all current smokers quit smoking, excessive alcohol users reduced their alcohol intake to moderate levels, people under 65 and those aged 65 and older increased their physical activity level by one hour and half an hour per day of moderate-intensity physical activity, and all participants ate 200g more fresh fruits and 50g more fish/seafood per day, LE at age 30 would increase by 4.83 (95% confidence interval [CI]: 4.01, 5.82) and 5.39 (95% CI: 4.70, 6.18) years for men and women, respectively. In the practical scenario, where improvements in each of the lifestyle factors were approximately halved, the gains in LE at age 30 for both men and women could be half those of the ideal scenario.Conclusions Our findings reinforce the evidence that population-wide lifestyle modifications can improve the LE of the whole Chinese population. If the current policy targets set by the Healthy China Initiative could be raised, a greater increase in LE would be achieved.
High-elevation orogenic plateau influences ecosystems
Authors: Zhang Zhiyong , Wang Nan , Luffi Peter , Li Zhiheng , Yu Zhiqiang , Wan Bo , Zhu Jing-Jing , Xiang Dunfeng , Guo Chao , Xiao Wenjiao
Published: January 2025

The interactions between plate tectonic processes and ecosystems are well-documented, but the precise influence of tectonic evolution on ecosystems remains elusive. This study investigates Jurassic–Cretaceous Northeastern Asia, where the Yanliao and Jehol Biotas flourished amid a prominent tectonic transition from crustal shortening to extension. To explore the impact of these processes on the ecosystem, we use innovative whole-rock geochemical composition-elevation models, alongside a large dataset from Late Triassic–Early Cretaceous arc magmatic rocks, to estimate regional-scale variations in paleo-crustal thickness, paleo-elevation, and paleo-temperature. Our results suggest that during the Jurassic, Northeastern Asia experienced significant crustal thickening, elevation increasing, and inland-ward magmatism due to plate convergence. By the Early Cretaceous, magmatism migrated outboard, driven by Paleo-Pacific slab rollback, leading to differential crustal thickness and elevation across the region. We propose an orogenic plateau with elevations of 2.0–4.5 km and mean annual temperatures of -1.0–12.8°C, creating complex topography that impacted spatiotemporal evolution of regional ecosystems and explains the high-elevation and cold habitats of the Yanliao and Jehol Biotas.
Epilobium parviflorum, hemorrhagic risk with anticoagulants
Authors: Beghriche Imene , Bensalem Samia , Fendri Allaoua Hicham
Published: January 2025

Plants have a crucial importance in our ecosystem. They contain complex mixtures of compounds that can interact with various therapeutics. Among them, the small-flowered willowherb (Epilobium parviflorum) has seen its use expand in recent years, particularly for prostate diseases.
The aim of this work is to demonstrate the risk of interaction between the use of E. parviflorum and medications, especially anticoagulants, illustrated by the case of our patient suffering from dilated cardiomyopathy, treated with acenocoumarol 4 mg, a vitamin K antagonist (VKA), for over a year.
The recent intake of small-flowered willow herb tea, rich in tannins and flavonoids, increased the patient's INR (International Normalized Ratio), indicating an increased risk of haemorrhage. A therapeutic education session was then held, with management of interactions and monitoring of the patient until stabilisation.
The intake of E. parviflorum or any other plant with anticoagulants requires rigorous pharmacological therapeutic monitoring to anticipate the risk of bleeding and improve the quality of life of patients.
Detection of Colombian datura virus infecting Brugmansia × candida medicinal cultivars and evaluation of sap inoculation in Solanaceae plants
Authors: Oliveros-Garay Oscar Arturo , González-Almario Adriana
Published: January 2025

Angel’s trumpets (Brugmansia spp.) are important medicinal plants belonging to the Solanaceae family that were domesticated in the Andean region of South America. Indigenous communities from the Colombian Andes have created cultivars with unusual leaf shapes and different medicinal uses. These cultivars exhibit symptoms on leaves associated with viral infection, such as mosaic, vein chlorosis, and morphological deformities. Previous studies have shown that the most widespread virus in Brugmansia is the Colombian datura virus (CDV), a globally distributed potyvirus that also affects agriculturally significant hosts. The present study aimed to evaluate the health status related to viral infections in Colombian Brugmansia medicinal cultivars and the relationship between the presence of viruses and the expression of symptoms in their leaves. We searched for CDV in the transcriptomes from a diverse collection of Solanaceae species and found it mainly in Brugmansia medicinal cultivars and wild solanaceous species. Sap from leaves of B. × candida cultivars with different symptoms were used as a source of CDV inoculum to infect representative cultivated plants of the Solanaceae family. We confirmed CDV infection of mechanically inoculated plants by RT-PCR and sequencing. Furthermore, we confirmed CDV ability to cause leaf deformations in agriculturally important plants such as Physalis peruviana, Solanum lycopersicum, and for the first time, reported the symptoms of the infection in Solanum melongena. In conclusion, this study is pioneering in characterizing a virus involved in the domestication of a medicinal plant.
Intranasal monoclonal antibodies do not prevent respiratory infection in a randomized, controlled experimental infection trial
Authors: Terstappen Jonne , Nibbelke Elisabeth E. , Ascough Stephanie , Bergstrom Emma , Bont Louis J. , Buiteman Brigitte J.M. , Chiu Chris , Cianci Daniela , Dayananda Pete , Delemarre Eveline M. , de Groot-Mijnes Jolanda D.F. , McCall Matthew B.B. , Reitsma Johannes B. , Schuurman Rob , Taylor Lydia , Troelstra Annet , Versnel Anouk , Vlaskamp Jacqueline , Viveen Marco , Zoggel J.A.A. van , Mazur Natalie I.
Published: January 2025

Intramuscular monoclonal antibodies (mAbs) can prevent respiratory infections but are costly and not globally available. The development of intranasal mAbs offers a promising cost-reducing and non-invasive alternative to systemic administration, though clinical evidence is lacking. Intranasal palivizumab prevented respiratory syncytial virus (RSV) infection in mice but not in healthy infants. This proof-of-concept study evaluates efficacy of intranasal palivizumab to prevent RSV infection. In this randomized, double-blind, placebo-controlled, experimental infection model, 28 healthy adults (18-55 years old) were randomized 1:1 to receive 1 mg/mL palivizumab in saline nasal drops or placebo. All participants were inoculated intranasally with RSV-A Memphis 37b strain one hour after administration of intranasal prophylaxis. The primary outcome of viral load was determined by RT-qPCR of nasal-wash samples 2-14 days post-inoculation. Symptoms were recorded by self-completed diaries. Intranasal palivizumab had no effect on viral load despite an 80% reduction in symptomatic infections. Upper respiratory tract symptoms over time were marginally lower in the intervention group compared to placebo. Intranasal palivizumab does not protect against RSV infection under optimally controlled conditions. Despite promising results in animal models, intranasal mAbs are highly unlikely to be a feasible and affordable method of protection against respiratory infection without high and frequent dosing. Funding: Lung Foundation Netherlands Junior Investigator Grant 5.2.20.020
QDsim: A user-friendly toolbox for simulating large-scale quantum dot devices
Authors: Gualtieri Valentina , Renshaw-Whitman Charles , Hernandes Vinicius , Greplova Eliska
Published: January 2025

We introduce QDsim, a Python package tailored for the rapid generation of charge stability diagrams in large-scale quantum dot devices, extending beyond traditional double or triple dots. QDsim is founded on the constant interaction model from which we rephrase the task of finding the lowest energy charge configuration as a convex optimization problem. Therefore, we can leverage the existing package CVXPY, in combination with an appropriate powerful solver, for the convex optimization which streamlines the creation of stability diagrams and polytopes. Through multiple examples, we demonstrate how QDsim enables the generation of large-scale dataset that can serve a basis for the training of machine-learning models for automated tuning algorithms. While the package currently does not support quantum effects beyond the constant interaction model, QDsim is a tool that directly addresses the critical need for cost-effective and expeditious data acquisition for better tuning algorithms in order to accelerate the development of semiconductor quantum devices.
EVALUATION OF THE NUTRITIONAL AND ANTIOXIDANT PROPERTIES OF FERMENTED AND NON-FERMENTED SABA SENEGALENSIS SEEDS
Authors:   Biotechnology and Valorization of Agroressources and Natural Substances Laboratory, Peleforo Gon Coulibaly University, Korhogo, Cote dIvoire., Zoro A.F. ,   Biotechnology Laboratory, Felix Houphouet Boigny University. Abidjan, Cote dIvoire., Kouame Y.Y. ,   Biotechnology and Valorization of Agroressources and Natural Substances Laboratory, Peleforo Gon Coulibaly University, Korhogo, Cote dIvoire.,   Biochemistry Pharmacodynamy Laboratory, Felix Houphouet Boigny, Abidjan, Cote dIvoire., Miezan B.A.P. ,   Biotechnology and Valorization of Agroressources and Natural Substances Laboratory, Peleforo Gon Coulibaly University, Korhogo, Cote dIvoire.,   Biochemistry Pharmacodynamy Laboratory, Felix Houphouet Boigny, Abidjan, Cote dIvoire., Soro M. ,   Biotechnology and Valorization of Agroressources and Natural Substances Laboratory, Peleforo Gon Coulibaly University, Korhogo, Cote dIvoire., Oussou K.F. ,   Deoartment of Food Engineering, Faculty of Agriculture, University of CuKurova 01330 Adana, Turkey., Toure A. ,   Biotechnology and Valorization of Agroressources and Natural Substances Laboratory, Peleforo Gon Coulibaly University, Korhogo, Cote dIvoire.,   Biochemistry Pharmacodynamy Laboratory, Felix Houphouet Boigny, Abidjan, Cote dIvoire.
Published: January 2025

Forest resources contribute to meeting the needs of populations through the supply of food and medicinal products. This study aimed to evaluate the nutritional and antioxidant properties of fermented and non-fermented seeds of Saba senegalensis. After 6 days of fermentation, the fermented and non-fermented seeds were dried for 8 days in the sun. Dried seeds were crushed and the flours obtained were used to determine the different parameters. Results of the nutritional properties of non-fermented and fermented seeds are respectively as follows: ash (1.87 and 1.79%), proteins (11.65 and 15.25%), lipids (6.05 and 5.34%) and fibers (54.25 and 52.25%). Mineral element contents are: Mg (55.09 and 50.33 mg/100g), Ca (95.23 and 80.55 mg/100g), zinc (3.15 and 2.83 mg/100g) and Fe (11.36 and 10.81 mg/100g). Concerning the antioxidant properties, the results are as follows: phenolic compounds (272.48 and 320.50 mg/100g), flavonoids (7.66 and 5.41 mg/100g) and tannins (98.81 and 80.81 mg /100g). Anti-radical activity of fermented and non-fermented seeds are 58.19 and 50.73% respectively. These results show that the consumption of Saba senegalensis seeds could contribute to the food security of populations.
CONSTRUCTION AND STANDARDIZATION OF ATTITUDE SCALE TOWARDS TECHNOLOGY
Authors:   Assistant Professor (Education), Govt. College, Dharamshala)., Mahajan Gourav
Published: January 2025

Education is at the confluence of powerful and rapidly shifting educational, technological and political forces that will shape the structure of educational systems across the globe for the remainder of this century.Technology can help facilitate the knowledge-constructed classroom. But there are many factors affecting the successful integration of technology into classroom teaching. These factors are associated with teaching-learning process, nature of content, attitude of teachers as well as of students. Present paper discusses the procedure of construction of attitude scale towards technology.
Exploring Female Hadith Transmitters: A Gender Perspective as a Modern Women’s History Lesson through Intelligent Ṣaḥabiyyāt
Authors: Friyadi Arif , Masruri Muhammad , Abdillah Aufa , Fatah Abdul , Sadili Imam
Published: January 2025

Islam encourages women to achieve the highest intellectual and spiritual abilities and does not prioritize men over women. The early generation of Islam, known as the Ṣaḥabiyyah (companions of the Prophet), played a significant role in narrating hadith from the first to the next generation. This study explores the role of the Ṣaḥabiyyāt (female companions of the Prophet) in narrating the greatest source of Islam, especially the hadith. The study uses a qualitative method, collecting data and inventorying female narrators from Jawāmi’ul Kālim software. The results show that over 160 female narrators from the time of the the Ṣaḥabat or Tābi’in played an active role in the transmission of hadith to the next generation. The intelligence of the Ṣaḥabiyyat not only became teachers but also of prominent male companions. The study can motivate females to be at the forefront of education and scientific transformation without fear of gender differentiation.
“Kepala Putik” on Women: Perspectives and Challenges in Balancing the Dual Role as Mother and Worker in Indonesia
Authors: Primadona Fitry , Lenggogeni Sari
Published: January 2025

The dual roles carried out by Indonesian women as both mothers and workers have increasingly garnered attention amidst dynamic social and economic changes. This article explores the concept of "Kepala Putik" as a perspective accompanied by the stigma faced by Indonesian women in fulfilling these dual roles. The research utilizes a qualitative method with a literature study approach. The primary data sources stem from a comprehensive review of relevant literature, including scholarly articles, books, and reports related to the dual roles of women in Indonesia. This study highlights the increasing participation of women in the workforce in Indonesia, focusing on a literature analysis to understand the social perspectives and challenges faced by women in balancing these dual roles. The uniqueness of this research lies in its emphasis on the specific concept of "Kepala Putik" and how this stigma uniquely affects Indonesian women. The findings of this study reveal the complexity of stereotypes and social norms related to women who choose to work while continuing to fulfil their roles as mothers.
A Novidade do Passado: a Sociologia Econômica no Brasil (1935-1979)
Authors: Fontella Odil Matheus
Published: January 2025

A partir de resgate bibliográfico, temático e institucional, realizado nos últimos dez anos, este artigo evidencia o desenvolvimento da disciplina de Sociologia Econômica no Brasil entre 1935 e 1979. O método aplicado foi o resgate histórico de artigos, capítulos, conferências, comunicações, relatórios de pesquisa e livros, além de eventual fortuna crítica, seja em material impresso, seja em formato digital. Para a análise qualitativa dos dados, desenvolveu-se análise textual, seguida de análises temática e interpretativa. As buscas textuais se concentraram em torno dos termos: “Sociologia Econômica”, “Sociologia da Economia”, “Sociologia da Vida Econômica”, “Estudos Sociais da Economia”, “Socioeconomia”, “Análise Sociológica da Economia”, “Aspectos Socioeconômicos”. Durante as cinco décadas analisadas, transpareceram no país abordagens sociológicas/socioeconômicas acerca de temáticas diversas como economia (atividade/disciplina), mercado, competição, empresa, grupos econômicos, dinheiro, (sub)desenvolvimento, Estado, capitalismo, estratificação social (classes sociais, renda), empreendedorismo. A disciplina acadêmica de Sociologia Econômica é longeva, extensa e diversificada no Brasil. Na busca por superar a amnésia sociológica que cerca a sua trajetória no país, apresenta-se este resgate bibliográfico, temático, autoral e institucional de tal disciplina como a novidade do passado.
The Triple Bottom Line in Language Tourism
Authors: Ceballos-Hernández Cristina , Alfalla-Luque Rafaela
Published: January 2025

The sustainable development of language tourism must be suppor­ted by the use of specific indicators capable of measuring the economic, social and environmental aspects related to the sector’s activity, in line with the Triple Bottom Line (TBL) concept. This is in line with Goal 12 of the Sustainable Development Goals (SDGs), which determines the importance of adequate reporting in these areas, allowing to manage, plan and moni­tor actions and results by stakeholders and companies. Given the need to determine specific indicators for this tourism, an analysis of high-impact scientific publications on this topic has been carried out. Reports, studies and publications from various sources and official bodies, both public and private, have been reviewed. The paper identifies the main factors of language tourism and proposes a series of indicators for measuring its economic, social and environmental impact. Finally, a SWOT analysis of the sector is carried out. Our study has clear implications for managers of language tourism companies, as well as political authorities, who will have a base of reference indicators to determine the triple impact of language tourism. The study contributes to ensuring that these activities are socially responsible, respectful of the environment and contribute to the sustainable development of the regions visited.
Avaliação da transição agroecológica em agroecossistemas de agricultura familiar
Authors:   , Silva Maria Janaína Nascimento
Published: January 2025

O uso indiscriminado dos recursos naturais tem ocasionado uma infinidade de problemas e boa parte deles são advindos da agricultura convencional, em que a maximização do capital para a obtenção de lucro se sobrepõe às questões sociais, ambientais e econômicas. Em contraponto a esse estilo de agricultura, surge a vertente de produção sustentável do agroecossistema, ocasionando a ruptura de paradigmas pré-existentes na agricultura, a partir da Transição Agroecológica em comunidades locais que estão inseridas nesse processo, contribui para a avaliação de sustentabilidade de agroecossistemas, possibilitando a análise de quais caminhos precisamos fortalecer e percorrer para explorar os recursos naturais sem maiores danos. O presente trabalho analisa níveis de transição agroecológica, em cinco agroecossistemas embasados na agricultura familiar agroecológica. A partir de indicadores ambientais, sociais e econômicos, que indicam para a transição da agricultura convencional para agricultura agroecológica. Para isso, conduziu-se este trabalho em agroecossistemas localizados na agrovila Paulo Freire, assentamento Maísa, Rio Grande do Norte. Nesse espaço, avaliou-se indicadores como banco de sementes, comercialização em feira, participação familiar, soberania alimentar, entre outros. Esses indicadores foram quantificados em uma escala numérica de 1, 2 e 3, representando nível inicial de transição agroecológica, nível intermediário de transição agroecológica e nível desejável de transição agroecológica, respectivamente, avaliados a partir de metodologias participativas como entrevistas semiestruturada. Ao fim da análise, concluiu-se que os agroecossistemas em questão estão em um nível intermediário de transição agroecológica, em que alguns fatores influenciaram o melhor desempenho dos outros, precisando de mais atenção quanto aos princípios agroecológicos.
Exploring the Physicochemical Compatibility of Minoxidil in Combination with Different Active Pharmaceutical Ingredients in Ready-to-use Vehicles for Alopecia Treatment
Authors: Marianni Bruna , Koulouridas Savvas , Polonini Hudson Caetano
Published: January 2025

Background:

Alopecia is globally known as a distressing medical disorder that affects
men and women, and current commercially available minoxidil solutions are formulated with irritant
vehicles with frequent complaints of dermatologic adverse effects.

Objectives:

This study aimed to investigate further the compatibility of ready-to-use vehicles for the
preparation of tailored formulations for alopecia treatment, namely TrichoSol™ (a ready-to-use vehicle
for personalized hair solutions) and TrichoFoam™ (a ready-to-use vehicle for personalized
foam formulations), in combination with minoxidil and other active pharmaceutical ingredients
(APIs), to establish adequate beyond-use dates (BUD) for the given formulations.

Methods:

Products under evaluation were compounded using TrichoSol™ or TrichoFoam™, with
direct incorporation of the APIs into these vehicles. Samples were then stored at controlled room
temperature for up to 180 days. High-performance liquid chromatography (HPLC) methods were
developed and validated, and then utilized to evaluate the compatibility of the APIs in TrichoSol™
and TrichoFoam™. Forced degradation studies were conducted to assess API stability under various
stress conditions, and Antimicrobial Effectiveness Testing (AET) was performed at 0 and 180 days
after compounding.

Results:

According to our results, BUDs of up to 90-180 days were obtained for the examined formulations
stored at room temperature, considering a degradation of maximum 10% of the nominal
concentration of the APIs within them. The formulations exhibited no discernible physical alterations
throughout this period and maintained chemical stability within acceptable limits. Microbiological
evaluations confirmed the efficacy of the preservative system.

Conclusion:

Products compounded with TrichoSol™ and TrichoFoam™ showed suitable stability to
be used as personalized treatments for alopecia. We can then suggest that the vehicles TrichoSol™
and TrichoFoam™ present effective solutions for compounding personalized hair care treatments.
Quinacrine Inhibits Hepatocellular Carcinoma Growth and Enhances the Anti-HCC
Effects of Lenvatinib
Authors: Xu Binhe , Hu Minli , Yang Hui , Xu Weikang
Published: January 2025

Background:

Hepatocellular Carcinoma (HCC) is a highly prevalent cancer worldwide, necessitating
effective treatment options. However, current treatments do not provide satisfactory results. Quinacrine, a synthetic
drug belonging to the 9-aminoacridine family, has demonstrated promising antitumor effects.

Objective:

The objective of the current study is to evaluate the anti-HCC effect of Quinacrine and explore whether
quinacrine can improve the anti-HCC response of lenvatinib in vitro and in vivo.

Methods:

The HepG2 and MHCC-97H cells were treated with Quinacrine. Cell proliferation and cell apoptosis
were assessed using the Cell Counting Kit-8 (CCK8) Assay, Colony Formation Assay, and Annexin V/7-AAD
staining method. The invasion and migratory ability of HepG2 and MHCC-97H cells were assessed by Transwell
Assay. The level of ROS of HCC cells was measured using a ROS-kit by Flow cytometric analysis. Besides, an in
vivo study was performed in the Balb/c nude mice bearing MHCC-97H tumors to analyze the function of Quinacrine
in tumor growth.

Results:

Quinacrine can decrease cell viability in HepG2 and MHCC-97H cells, but not affect LO2 cells. Quinacrine
impaired the colony formation, invasion and migratory ability in half-maximal inhibitory concentration
(IC50). Quinacrine also significantly induced apoptosis in HepG2 and MHCC-97H cells in a concentrationdependent
manner. On the one hand, ROS was significantly up-regulated in HCC cells after quinacrine treatment.
On the other hand, We found quinacrine blocked autophagy flux in HepG2 and MHCC-97H cells. Moreover,
Quinacrine significantly enhances the anti-HCC efficacy of lenvatinib in vitro. In the mouse MHCC-97H model,
We found that combination therapy with Quinacrine and lenvatinib resulted in a smaller tumor volume and weight
than inoculated with lenvatinib alone.

Conclusion:

Our findings demonstrated that quinacrine exerts anti-HCC effects and sensitizes hepatocellular
carcinoma to lenvatinib. Collectively, our study provides novel therapeutic insights for managing HCC and offers
a valuable strategy for future clinical interventions in this field.
PLGA Polymers and Doxorubicin for the Treatment of Malignant Gliomas in Adults: An Overview
Authors: Kudelkina Vera V. , Gerasimov Andrey D. , Kosyreva Anna M. , Alekseeva Anna I. , Makarova Olga V.
Published: January 2025

Malignant brain tumors, such as glioblastoma and astrocytoma, are the most aggressive diffuse gliomas with a high grade (4) of malignancy in adults, leading to high mortality. The development of pharmacological approaches to drug delivery systems has led to increased effectiveness and reduced systemic toxicity of anticancer therapy. Delivery systems, such as implants, plates, gels, and micro- and nanoparticles, are used as carriers for anticancer substances, improving their solubility and biodistribution. These delivery systems affect the mechanism of drug action, reduce toxicity, Micro- and nanoparticles can penetrate physiological barriers of the body, including the blood-brain barrier (BBB). Due to changes in the microvascular system, they linger and accumulate in the area of pathology. Despite extensive data on delivery systems, only a few have undergone clinical trials and been adopted into clinical practice. For over 20 years, polymeric plates containing carmustine have been clinically used to treat malignant brain tumors. The search for safer and more effective forms of drug anti-tumor agents continues, as glioblastoma remains an incurable disease. Doxorubicin is a primary chemotherapy agent with proven efficacy, which is included in standard therapy for almost all tumor types. However, it is not used to treat central nervous system tumors, as it is believed that it does not cross the BBB. The polymers of lactic acid and glycolic acid (PLGA or PLG) are biocompatible and biodegradable. Standards for different tumor types where doxorubicin is used. We describe the mechanisms of action of polymeric and nanoparticle forms of chemotherapy drugs, the prospects of using PLGA polymers, and assess possible ways to deliver doxorubicin and other medications for brain tumors effectively.
Parasitic Resistance Impacting Fill Factor of a GaAs Solar Cell
Authors: Gayan Abhilash , Biswas Rajib
Published: January 2025

The efficiency of a photovoltaic cell is determined by the maximum power it can deliver to a load. Power output is a function of the fill factor. The fill factor determines the shape of the
I-V characteristics of a solar cell. It is dependent on various environmental as well as internal parameters. Two major parameters that influence the fill factor are the parasitic series and shunt resistances (RS and RSH) present in a photovoltaic device.

In this regard, numerical analysis has been carried out to determine the effect of these parasitic
influences on the I-V characteristics of a solar cell and to analyze the variation of the fill factor
with the two parasitic resistances.

The highest recorded efficiency and other corresponding parameters for a GaAs (multicrystalline)
solar cell have been used for reference while conducting the analysis. It is observed that the I-V
curve flattens for decreasing values of RSH, and the fill factor decreases considerably.

It is envisioned that the attained results will pave the way for implementations ensuring higher
efficiency of GaAs solar cells
La espiritualidade en los Sitios Reales de los diversos reinos de la Monarquía Hispánica durante el siglo XVII capillas, palacios, conventos y monasterios reales
Authors: Hortal Muñoz José Eloy
Published: January 2025

The question of religious practices is crucial to the study of Early Modern times, not just exclusively associated with the field of religion, as it has been mainly studied so far, but as an essential aspect of studying the justification of power, the pre-eminence of (ecclesiastical and temporal) institutions and, in the case of the Spanish monarchy, its relations with the Holy See The Royal Sites of the Spanish monarchy were relevant in this respect, since they formed a diverse global network, especially in the seventeenth century, when they were centers of power that helped to shape the Spanish monarchy politically and socially. Institutions under royal control included not only the king’s royal palaces and the royal chapels attached to them, but also magnificent convents and individual monasteries belonging to specific religious orders with close affiliations to the Habsburg dinasty. This institutional network extended across the different kingdoms of the Iberian Peninsula and beyond to other territories in Europe, America and Asia that were at various times under Spanish rule.This article provides new insights of research developed in recent years, which analyse the intertwining of these Royal Sites with the different religious and political trends of the period, especially in questions related to the forms of religiosity and royal piety, using examples from most of the courts that made up the Spanish monarchy during the 17th century.
Ambivalent Laughter: Conceptual Poetry's Humor and Metamodernism
Authors: Siltanen Elina
Published: January 2025

Conceptual poetry can easily be viewed as a postmodern phenomenon, but in this
essay, I argue that the way some conceptual poems relate to humor suggests a metamodern
sensibility. Metamodernism operates between tonal ambiguities like “irony and enthusiasm”
which are key elements in Robin van den Akker and Timotheus Vermeulen’s (2017) definition of
the term. I consider poems from three writers, Alexandra Nemerov’s “First My Motorola”, Lawrence
Giffin’s “Spinoza’s Ethics”, and Marcella Durand’s “Pastoral” and “Pastoral 2”. These poems can
be read as being critical of capitalism through humor. The poems do not merely propose an
ironic reading but, instead, can be read as evoking ambivalent laughter as affect (see Hennefeld
2021). These kinds of poems recycle seemingly infinite material from contemporary everyday
life and invite the reader to consider this infinite material through ambivalent laughter
Homo Humour: Metamodernist Acts of Secrecy, Homosexual Identity and Humorous Word Play
Authors: Campbell Lee
Published: January 2025

This chapter demonstrates how I have worked with humour and the mechanisms of
comedy in both my practice as a curator and an artist influenced by metamodernist thinking
working across visual art, performance, and filmic forms. These examples show how gay men
have a specific skill at using humourous word play performatively. The chapter begins with a
discussion about my current curatorial moving image project Homo Humour (2020 – now) and
then highlights my solo poetry performance Clever at Seeing Without Being Seen (2021) and
several of my own short poetry films. The chapter concludes with discussion about how I have
worked creatively with the gay slang language of Polari.
Can I Laugh or Should I Cry? Humor and Politics in Some Cases of Contemporary Experimental Writing in Latin America
Authors: Villa-Forte Leonardo
Published: January 2025

Starting from the premise of the global impact of technology on the acts of reading
and writing, the essay elaborates on the expression of political humor in what I call “secondhand writing” based on characteristics of Latin America. Certain recent fictional and poetic
production of an experimental nature, with a focus on Brazil, Chile and Mexico, is analyzed in
terms of their recycling and non-originality procedures, and especially their practice of irony,
parody and corrosive humor as a tool for reviewing colonial and post-colonial history in terms
of state, gender, racial and linguistic violence.
Insomma, una Beffa. Humour as a Form or Re-writing, Re-engaging, Re-thinking Women. The Experimental Poetry of Giulia Niccolai
Authors: D'Amico Marzia
Published: January 2025

The aim of this essay is to present a critical-practical reflection on the use of
humour in poetry as a form of subversion of power (Colebrook, 2004). It will be seen in
more detail how power is not a useful dimension for the feminist battle (hooks, 1990) and
the expression of non male subjects, who rather create a different framework in which they
operate (Borghi, 2020). Through a reading that revisits the term empowerment (Naidotti,
1998), a word nowadays expropriated of its political and subversive charge, we can return to
reading Giulia Niccolai’s poetry, over the course of an entire career, with examples from her
earliest and latest production, as a posture in the world made up of sincere and critical irony
and conscious stance.
Pengaruh Kredibilitas Influencer Terhadap E-Review Dan Minat Beli Produk
Authors: Tabriza Tasya , Rohman Fatchur
Published: January 2025

This research aims to focus on finding out the effect or influence given by influencer credibility on purchase intention through e-review as an intervening variable on Somethinc products. The research method used is explanatory with a quantitative approach. The research sample consisted of 100 respondents who are TikTok users in the Jabodetabek area and have knowledge about Somethinc products from TikTok. The data analysis was carried out using Structural Equation Modeling - Partial Least Squares (SEM-PLS) technique with the help of SmartPLS software. The results of the study concluded that influencer credibility has a significant effect on e-review and e-review has a significant effect on purchase intention in Somethinc products. This finding indicates that when TikTok users feel that the influencers they follow have high credibility in recommending Somethinc products, their purchase intention also increases, partly through the e-review process.
 
Abstrak
Penelitian ini dilakukan dengan fokus mencari tahu peran atau pengaruh yang diberikan kredibilitas influencer terhadap e-review dan minat beli pada produk Somethinc. Metode penelitian yang digunakan adalah eksplanatori dengan pendekatan kuantitatif. Sampel penelitian terdiri dari 100 responden yang merupakan pengguna TikTok di wilayah Jabodetabek dan memiliki pengetahuan tentang produk Somethinc dari Tiktok. Analisis data dilakukan menggunakan teknik Structural Equation Modeling - Partial Least Squares (SEM-PLS) dengan bantuan perangkat lunak SmartPLS. Hasil dari penelitian disimpulkan bahwa kredibilitas influencer memiliki pengaruh signifikan terhadap e-review dan e-review berpengaruh signifikan terhadap minat beli pada produk Somethinc. Temuan ini mengindikasikan bahwa ketika pengguna TikTok merasa bahwa influencer yang mereka ikuti memiliki kredibilitas yang tinggi dalam merekomendasikan produk Somethinc, minat beli mereka juga meningkat, sebagian melalui proses e-review.
Arte + Ciencia + Diseño. Transdisciplina experimental
Authors: Dal Farra Ricardo
Published: January 2025

En ocasiones, los modos de resolver los problemas llegan aplicando los procedimientos esperados y probados, pero otras veces no. ¿Tendremos la flexibilidad para aceptar que no todo puede resolverse empleando las metodologías desarrolladas hasta ahora? Solo basta mirar a nuestro alrededor un instante, ponerse a pensar si los problemas más graves que afronta la especie humana actualmente están en vías de solucionarse o si no se ve aún con claridad qué hacer y cómo avanzar. Necesitamos buscar formas innovadoras de alcanzar nuestros propósitos a través de procesos que modifiquen ideas, elementos o protocolos ya existentes para mejorarlos o crear nuevos, de modo tal que tengan un impacto positivo en la sociedad.
Aunque la solución de problemas complejos se explora, cada vez más, desde perspectivas multi o interdisciplinarias, estas estrategias no son suficientes en muchos casos, por lo que el desarrollo de un enfoque transdisciplinar se convierte en una herramienta esencial. ¿Podrían reencontrarse las artes y las ciencias para retomar un vínculo —casi olvidado— que nos remita a una visión más integrada de lo que acontece en el mundo? ¿Puede el diseño, con sus múltiples intepretaciones, a veces liderando procesos o entrecruzándose con las miradas que nos permiten entender el hacer con modos renovados, sumarse a un nuevo modelo de generación de esperanzas y producción de resultados positivos?
A continuación, este artículo ofrece conceptos y comparte algunos proyectos en los que la investigación-creación y una visión de lo que podríamos pensar como diseño + arte + ciencia se proponen a modo de reflexión (para la acción), en la búsqueda de una renovación en los modos de pensar, de hacer, de entender, de comprender el pasado, construyendo el presente y proyectando lo que vaya a venir.