bluuebunny/crossref_metadata_2025 huggingface dataset:
Alternative Treatments for Zirconium Oxide to Compare Commonly Used Surface Treatments to Determine Which Has the Least Effect on the Phase Transformation
Authors: Śmielak Beata , Klimek Leszek
Published: October 2024

Traditional mechanical processing of zirconium leads to an unfavorable transformation, from a metastable tetragonal phase to a monoclinic phase (t→m), which weakens the structure of the material and subsequently leads to damage to the prosthetic restoration. The aim of this research is to compare commonly used surface treatments to determine which has the least effect on t→m. Thirty cylindrical samples made of sintered zirconium were divided into six groups based on the following treatments: polishing, grinding, sandblasting, chemical etching, laser structuring or dry plasma etching. After surface treatment, the samples were subjected to the following tests: X-Ray Diffraction, microscopic examination, surface wettability and surface roughness measurements. Chemical etching, laser structuring and plasma etching significantly reduce the content of the monoclinic phase. All surface treatments significantly reduced the final amount of the monoclinic phase. However, chemical etching did not provide sufficient surface roughness. Both laser and plasma processing offer the advantage of creating structural patterns on the surface of elements. However, as plasma etching requires a mask to obtain the appropriate pattern on the surface, it seems that laser processing offers more and varied structuring possibilities. Laser structuring is easier to control and more economical than the other methods.
An Enhanced Progressive Damage Model for Laminated Fiber-Reinforced Composites Using the 3D Hashin Failure Criterion: A Multi-Level Analysis and Validation
Authors: Zhang Yichen , Van Paepegem Wim , De Corte Wouter
Published: October 2024

This paper presents a progressive damage model (PDM) based on the 3D Hashin failure criterion within the ABAQUS/ExplicitTM 2021 framework via a VUMAT subroutine, enhancing the characterization of the mechanical performance and damage evolution in the elastic and softening stages of composite materials via the accurate calculation of damage variables and accommodation of non-monotonic loading conditions. In the subsequent multi-level verification, it is found that the model accurately simulates the primary failure modes at the element level and diminishes the influence of element size, ensuring a reliable behavior representation under non-monotonic loading. At the laminate level, it also accurately forecasts the elastic behavior and damage evolution in open-hole lamina and laminates, demonstrating the final crack band at ultimate failure. This paper also emphasizes the importance of correct characteristic length selection and how to minimize mesh size impact by selecting appropriate values. Compared to ABAQUS’s built-in 2D model, the 3D VUMAT subroutine shows superior accuracy and effectiveness, proving its value in characterizing the mechanical behavior and damage mechanisms of fiber-reinforced polymer (FRP) materials. The enhanced 3D PDM accurately characterizes the softening processes in composite materials under simple or complex stress states during monotonic or non-monotonic loading, effectively minimizes the mesh dependency, and reasonably captures failure crack bands, making it suitable for future simulations and resolutions of numerical issues in composite material models under complex, three-dimensional stress states.
Evaluation of Mechanical Energy Consumption in WPC Production from Pine (Pinus sylvestris) and Hemp (Cannabis sativa L.) with ABS Thermoplastic Additions
Authors: Roman Kamil , Grzegorzewska Emilia , Fedorowicz Katarzyna , Michalczewski Jakub
Published: October 2024

This study investigates lignocellulosic biocomposites’ physicochemical properties and strength parameters with varying thermoplastic content. Biocomposites were prepared using wood (Pinus sylvestris) or hemp shives (Cannabis sativa L.) combined with 25% and 50% ABS regranulate. The research focused on evaluating the mechanical energy consumption during the compaction of wood-ABS biocomposites with different pine fractions pretreated with hot water extraction (HWE) and analyzing the relationship between strength and thermoplastic content. Results indicate that the composition of the mixture and the size of the hemp shives fraction did not significantly influence energy consumption during densification. Energy values ranged from 1.234 × 10⁻8 J to 8.296 × 10⁻8 J. While the densification of pine after HWE was unsuccessful without ABS, preheating the mixtures with ABS facilitated the production of a uniform composite. The work required for densification ranged from 1.404 × 10⁻5 J to 2.711 × 10⁻5 J for fractions without ABS. For mixtures with ABS, the work required was 1.954 × 10⁻5 J for fraction 0 ÷ 0.4 (f1) and 0.042 × 10⁻5 J for fraction 0.4 ÷ 0.8.
Flexural Strength of Modern CAD/CAM Restoratives After Artificial Aging
Authors: Melc Thomas , Attin Thomas , Eyüboğlu Tan Fırat , Özcan Mutlu
Published: October 2024

Before clinical trials are initiated, studying the mechanical performance of modern CAD/CAM restorative materials exposed to aging conditions would provide insights on their performance in service. This study evaluated the impact of thermomechanical aging on various resin composite, ceramic, hybrid, and nano-filled resin composite materials after two polymerization modes. Specimens (3 × 4 × 14 mm3) were fabricated using (n = 12 per group) a universal composite (Filtek Supreme XTE photo-polymerized for either 40 s or 120 s per layer), hybrid ceramics (BRILLIANT Crios, GC Cerasmart, Lava Ultimate, VITA ENAMIC), glass ceramics (IPS e.max CAD, VITA Suprinity PC, Straumann n!ce), or feldspar ceramics (VITABLOCS Mark II, GC Initial LRF). In each group, half of the specimens underwent thermomechanical aging. A three-point bending test was applied to all specimens and the results were statistically analyzed (α = 0.05). Glass ceramics and hybrid ceramics presented higher flexural strength values than feldspar ceramics and the universal composite before and after aging (p < 0.05). Thermomechanical cycling affected the flexural strength of all materials (p < 0.05) except Lava Ultimate, Straumann n!ce, and GC Initial (p > 0.05). The highest decrease in flexural strength after aging was found in the universal composite (40 s polymerization) (p < 0.001) and Vita Enamic (p < 0.001), while the lowest decrease was in the hybrid ceramics, Cerasmart and Lava Ultimate (p < 0.05). Extending polymerization duration reduced the aging effect on the universal composite tested. Thermomechanical aging affected the flexural strength of most materials tested. Universal composites and feldspar ceramics presented similar flexural strength values.
Interaction and Diffusion Mechanism of Moisture in Power Capacitor Insulating Oil Based on Molecular Simulation
Authors: Wei Changyou , Pang Zhiyi , Qin Rui , Huang Jiwen , Li Yi
Published: October 2024

Characterized by its exceptional electrical, physical, and chemical properties, 1-phenyl-1-xylylethane (PXE) insulating oil finds extensive application in the realm of power capacitor insulation. In this study, molecular simulation is employed to investigate the reactivity of PXE insulating oil molecules and the impact of temperature on water diffusion behavior in PXE insulating oil, as well as its solubility. The findings demonstrate a higher propensity for hydrogen atoms in nucleophilic and electrophilic positions within PXE insulating oil molecules to interact with water molecules. The inclusion of a temperature field enhances the Brownian motion of water molecules and improves their diffusion ability within the oil. Furthermore, the temperature field diminishes the interaction force between water molecules and the oil medium. Under the influence of this temperature field, there is an increase in the free volume fraction of PXE insulating oil, leading to a weakening effect on hydrogen bonds between oxygen and hydrogen atoms within PXE insulating oil. Additionally, with increasing temperature, there is an elevation in moisture solubility within insulating oil, resulting in a transition from a suspended state to a dissolved state.
Fundamental Study of Phased Array Ultrasonic Cavitation Abrasive Flow Polishing Titanium Alloy Tubes
Authors: Dai Yuhan , Li Sisi , Feng Ming , Chen Baiyi , Qiao Jiaping
Published: October 2024

A new method of machining ultrasonic cavitation abrasive flow based on phase control technology was proposed for improving the machining efficiency of the inner wall of TC4 (Ti-6Al-4V) titanium alloy tubes. According to ultrasonic phase control theory and Hertzian contact theory, a model of ultrasonic abrasive material removal rate under phase control technology was established. Using COMSOL Multiphysics 6.1 software, the phase control deflection effect, acoustic field distribution, and the size of the phase control cavitation domain on the inner wall surface were examined at different transducer frequencies and transducer spacings. The results show that the inner wall polishing has the most excellent effect at a transducer frequency of 21 kHz and spacing of 100 mm. In addition, the phased deflection limit was explored under the optimal parameters, and predictive analyses were performed for voltage control under uniform inner wall polishing. Finally, the effect of processing time on polishing was experimented with, and the results showed that the polishing efficiency was highest from 0 to 30 min and stabilized after 60 min. In addition, the change in surface roughness and material removal of the workpiece were analyzed under the control of the voltage applied, and the experimental results corresponded to the voltage prediction analysis results of the simulation, which proved the viability of phase control abrasive flow polishing for the uniformity of material removal of the inner wall of the tube.
A Study on the Compressive Behavior of Additively Manufactured AlSi10Mg Lattice Structures
Authors: Liović David , Kršćanski Sanjin , Franulović Marina , Kozak Dražan , Turkalj Goran , Vaglio Emanuele , Sortino Marco , Totis Giovanni , Scalzo Federico , Gubeljak Nenad
Published: October 2024

The mechanical behavior of the metallic components fabricated by additive manufacturing (AM) technologies can be influenced by adjustments in their microstructure or by using specially engineered geometries. Manipulating the topological features of the component, such as incorporating unit cells, enables the production of lighter metamaterials, such as lattice structures. This study investigates the mechanical behavior of lattice structures created from AlSi10Mg, which were produced using the laser beam powder bed fusion (LB-PBF) process. Specifically, their behavior under pure compressive loading has been numerically and experimentally investigated using ten different configurations. Experimental methods and finite element analysis (FEA) were used to investigate the behavior of body-centered cubic (BCC) lattice structures, specifically examining the effects of tapering the struts by varying their diameters at the endpoints (dend) and midpoints (dmid), as well as altering the height of the joint nodes (h). The unit cells were designed with varying parameters in such a way that dend is changed at three levels, while dmid and h are changed at two levels. Significant differences in Young’s modulus, yield strength, and ultimate compressive strength between the various specimen configurations were observed both experimentally and numerically. The FEA underestimated the Young’s modulus corresponding to the configurations with thinner struts in comparison to the higher values found experimentally. Conversely, the FEA overestimated the Young’s modulus of those configurations with larger strut diameters with respect to the experimentally determined values. Additionally, the proposed FE method consistently underestimated the yield strength relative to the experimental values, with notable discrepancies in specific configurations.
Development of Technologies for Processing Polypropylene Foil Waste and Their Use in the Production of Finished Products
Authors: Dziadowiec Damian , Walburg Karina , Matykiewicz Danuta , Andrzejewski Jacek , Szostak Marek
Published: October 2024

This work aims to assess the possibility of using packaging industry waste to modify polypropylene products (PPs). The products were made in the form of extruded foil and injected samples. The products were produced using regranulate made of polypropylene cast foil. Maleic anhydride-modified polypropylene (MAPP) and polyolefin elastomer (POE) with a glycidyl ester functional group were used to modify the polypropylene. The samples were produced based on 50% foil waste reground and 50% pure PP. The rheological properties of the blends were assessed using the melt mass flow rate (MFR) technique; thermal properties using the differential scanning calorimetry method (DSC). The products manufactured using the injection molding method were subjected to an analysis of mechanical properties, such as tensile strength and impact strength. Also, in the case of film samples, tensile strength was assessed. Color-change assessments with CIE L*a*b* were carried out for all materials. Injection-molded products based on recycled metallized cast foil showed favorable mechanical properties such as tensile strength (1 MAPP = 26.7 MPa; 2 MAPP = 27.1 MPa), which was higher than the original material (cPP = 20.7 MPa). Also, for the films produced from regrind, the tensile strength was at a level similar (1 MAPP = 24.6 MPa; 2 MAPP/POE = 25.1 MPa) to the films extruded from virgin materials (cPP = 24.9 MPa). The introduction of a POE additive to the blends resulted in increased impact strength (1 MAPP/POE = 31 kJ/mol; 2MAPP/POE = 18 kJ/mol; 3 MAPP/POE = 11 kJ/mol) in relation to unmodified samples (cPP = 7 kJ/mol). The introduction of a POE additive to the tested mixtures improved the impact strength of the injected products by almost 4 times for sample 1 MAPP/POE and 2.5 times for sample 2 MAPP/POE in comparison to virgin cPP. These studies confirmed that foil waste can be successfully used to modify polypropylene products shaped both in the injection and extrusion processes.
Torque Characteristics Analysis of Slotted-Type Axial-Flux Magnetic Coupler in the Misalignment State
Authors: Qi Yutang , Yang Chaojun , Zhang Yiwen , Guo Chao , Tadesse Amberbir Wondimu
Published: October 2024

In this article, a simple and practical magnetic equivalent charge model is proposed to predict the torque of a slotted-type axial-flux magnetic coupler (SAMC) under conditions of radial misalignment, angle misalignment, and synthetic misalignment. The magnetic field generated by the permanent magnet (PM) disk and the induced magnetic field generated by the slotted conductor sheet (CS) are equivalent to the surface magnetic charge, respectively. Particularly, the induced magnetic field produced by eddy current considering skin depth in the conductor sheet is introduced into the magnetic equivalent charge model. Combined with Coulomb’s law of magnetic field, the formulas of torque and axial force are both derived. Using this method, the torques in three cases of misalignment are calculated. Finally, the effectiveness of the model is verified by the finite element method (FEM) and experiment; the results calculated by the magnetic equivalent charge model are basically consistent with those from the finite element method and experiment. The derived formula is suitable for small air gaps, small slip rates, and small radial deflection distances. Additionally, the limitations of the method proposed are discussed, which is of great help for understanding the torque transmission of the magnetic coupler in the misalignment state.
Methodology and Experimental Verification for Predicting the Remaining Useful Life of Milling Cutters Based on Hybrid CNN-LSTM-Attention-PSA
Authors: Zhu Mengge , Zhang Ji , Bu Lingfan , Nie Sen , Bai Yu , Zhao Yueqi , Mei Ning
Published: October 2024

In modern manufacturing, the prediction of the remaining useful life (RUL) of computer numerical control (CNC) milling cutters is crucial for improving production efficiency and product quality. This study proposes a hybrid CNN-LSTM-Attention-PSA model that combines convolutional neural networks (CNN), long short-term memory (LSTM) networks, and attention mechanisms to predict the RUL of CNC milling cutters. The model integrates cutting force, vibration, and current signals for multi-channel feature extraction during cutter wear. The model’s hyperparameters are optimized using a PID-based search algorithm (PSA), and comparative experiments were conducted with different predictive models. The experimental results demonstrate the proposed model’s superior performance compared to CNN, LSTM, and hybrid CNN-LSTM models, achieving an R2 score of 99.42% and reducing MAE, RMSE, and MAPE by significant margins. The results validate that the proposed method has significant reference and practical value for RUL prediction research of CNC milling cutters.
Emerging Vibrio vulnificus-Associated Infections After Seawater Exposure—Cases from the Bulgarian Black Sea Coast
Authors: Radeva Stephanie , Vergiev Stoyan , Georgiev Georgi , Niyazi Denis
Published: October 2024

Objectives: The aim of the current report is to present three cases of necrotizing fasciitis and sepsis caused by Vibrio vulnificus on the Bulgarian Black Sea coast. Materials and Methods: Two of the patients are males, 70 and 86 years of age, respectively, and one is an 86-year-old female. Data were collected from the patients’ examination records. V. vulnificus was isolated on 5% sheep blood agar from wound and blood samples and identified by the automated system Phoenix M50 (BD, Franklin Lakes, NJ, USA). Antimicrobial susceptibility was tested with two well-known methods (disk diffusion and broth microdilution). Results: All of the patients were admitted to our hospital due to pain, swelling, ulceration, and bullae on the legs and were febrile. They underwent surgery and received intensive care support. One of the patients developed septicemia and septic shock; one of his legs was amputated, but the outcome was fatal. The other patient received immediate approptiate antibiotic and surgical treatment, and the outcome was favorable. The third patient underwent emergency fasciotomy but died a few hours after admission. Conclusions: Global climate change is affecting the distribution of Vibrio spp., and their incidence is expected to increase. It is important to highlight the need for awareness among immunocompromised and elderly patients of the potential threat posed by V. vulnificus infections.
Association of Narrow Anterior Communicating Artery or Contralateral A1 Segment with Poor Outcomes After Mechanical Thrombectomy
Authors: Širvinskas Audrius , Ledas Giedrius , Levulienė Rūta , Markevičiūtė Jurgita , Mosenko Valerija , Afanasjev Andrej , Vilionskis Aleksandras , Lukoševičius Saulius , Tamošiūnas Algirdas Edvardas
Published: October 2024

Background and Objectives: Contralateral A1 and AComA aplasia/hypoplasia are critically important in distal ICA T occlusion as the protective collateral blood supply from the circle of Willis via the anterior communicating artery is compromised. Although the terms aplasia/hypoplasia are used broadly in the literature, the need for concrete measurements and data on their clinical significance is apparent. Features of the individual anatomy of the circle of Willis may determine patient outcomes. We aim to determine the cut-off values of contralateral A1 and AComA segments that determine worse outcomes for patients with acute ischemic stroke with T occlusion of the terminal internal carotid artery. Material and Methods: Retrospective patient data from 2015 to 2020 and prospective data from 2021 to 2022 of 482 patients with diagnosed acute ischemic stroke that underwent mechanical thrombectomy at the Republican Vilnius University Hospital (Vilnius, Lithuania) were obtained. Of these patients, 70 were selected with occlusion of internal carotid artery bifurcation and extension to M1 or A1 segments. For statistically significant interactions, patient data were analyzed using two statistical methods (logistic regression and Multivariate Adaptive Regression Splines (MARS)). Results: The narrowest segment of contralateral A1 and/or AComA was statistically significant for 7-day NIHSS, and the optimal cut-off points for this variable were 1.1 mm (MARS model) and 1.2 mm (logistic regression, p = 0.0079, sensitivity 66.7%, specificity 67.9%). The other considered variables (age, gender, time from last seen well to groin puncture, intravenous recombinant tissue plasminogen activator, admission NIHSS, and ASPECT score) and their interactions were not statistically significant. Conclusions: A negative correlation was found between the narrowest segment and seven days of NIHSS. A larger diameter of contralateral A1 and AComA appears to be essential for better patient outcomes at 7-day evaluation post mechanical thrombectomy.
The Role of ABCB1, ABCG2, and SLC Transporters in Pharmacokinetic Parameters of Selected Drugs and Their Involvement in Drug–Drug Interactions
Authors: Kiełbowski Kajetan , Król Małgorzata , Bakinowska Estera , Pawlik Andrzej
Published: October 2024

Membrane transporters are expressed in a wide range of tissues in the human organism. These proteins regulate the penetration of various substances such as simple ions, xenobiotics, and an extensive number of therapeutics. ABC and SLC drug transporters play a crucial role in drug absorption, distribution, and elimination. Recent decades have shown their contribution to the systemic exposure and tissue penetration of numerous drugs, thereby having an impact on pharmacokinetic and pharmacodynamic parameters. Importantly, the activity and expression of these transporters depend on numerous conditions, including intestinal microbiome profiles or health conditions. Moreover, the combined intake of other drugs or natural agents further affects the functionality of these proteins. In this review, we will discuss the involvement of ABC and SLC transporters in drug disposition. Moreover, we will present current evidence of the potential role of drug transporters as therapeutic targets.
Seasonal Variations of Sediment Fungal Community of a Shallow Lake in North China
Authors: Yi Yujun , Yin Senlu
Published: October 2024

Fungi play important roles in the process of material cycling and energy transfers in aquatic ecosystems. Yet, little is known about the fungal community in lake sediment. In this study, sediment samples from five habitat types in Baiyangdian Lake (BYD Lake) were collected across three seasons. High-throughput sequencing techniques were used to determine the compositions of fungal communities. Fungi are highly diverse in the sediment of BYD Lake, although some important fungi have not been accurately identified. The fungal diversity was highest in winter and lowest in summer, while there was no significant difference in species richness among sampling sites. The compositions of fungal community differed among seasons and habitats. Physicochemical properties of sediments were measured and the influence of the environmental factors on fungal communities were analyzed. Temperature, P, N, and heavy metals explained 48.98% of the variations of fungal communities across three seasons. Human activities have affected the species and biomass of fungi to some extent. Temperature is the most influential factor and negatively correlated to fungal diversity. Nutrients in different forms have different effects on shaping the fungal community. The effect of heavy metals is relatively low.
Combination of Silicate-Based Soil Conditioners with Plant Growth-Promoting Microorganisms to Improve Drought Stress Resilience in Potato
Authors: Mamun Abdullah Al , Neumann Günter , Moradtalab Narges , Ahmed Aneesh , Nawaz Fahim , Tenbohlen Timotheus , Feng Jingyu , Zhang Yongbin , Xie Xiaochan , Zhifang Li , Ludewig Uwe , Bradáčová Klára , Weinmann Markus
Published: October 2024

Due to shallow root systems, potato is a particularly drought-sensitive crop. To counteract these limitations, the application of plant growth-promoting microorganisms (PGPMs) is discussed as a strategy to improve nutrient acquisition and biotic and abiotic stress resilience. However, initial root colonization by PGPMs, in particular, can be affected by stress factors that negatively impact root growth and activity or the survival of PGPMs in the rhizosphere. In this study, perspectives for the use of commercial silicate-based soil conditioners (SCs) supposed to improve soil water retention were investigated. The SC products were based on combinations with lignocellulose polysaccharides (Sanoplant® = SP) or polyacrylate (Geohumus® = GH). It was hypothesized that SC applications would support beneficial plant–inoculant interactions (arbuscular mycorrhiza, AM: Rhizophagus irregularis MUCL41833, and Pseudomonas brassicacearum 3Re2-7) on a silty loam soil–sand mixture under water-deficit conditions (6–12 weeks at 15–20% substrate water-holding capacity, WHC). Although no significant SC effects on WHC and total plant biomass were detectable, the SC-inoculant combinations increased the proportion of leaf biomass not affected by drought stress symptoms (chlorosis, necrosis) by 66% (SP) and 91% (GH). Accordingly, osmotic adjustment (proline, glycine betaine accumulation) and ROS detoxification (ascorbate peroxidase, total antioxidants) were increased. This was associated with elevated levels of phytohormones involved in stress adaptations (abscisic, jasmonic, salicylic acids, IAA) and reduced ROS (H2O2) accumulation in the leaf tissue. In contrast to GH, the SP treatments additionally stimulated AM root colonization. Finally, the SP-inoculant combination significantly increased tuber biomass (82%) under well-watered conditions, and a similar trend was observed under drought stress, reaching 81% of the well-watered control. The P status was sufficient for all treatments, and no treatment differences were observed for stress-protective nutrients, such as Zn, Mn, or Si. By contrast, GH treatments had negative effects on tuber biomass, associated with excess accumulation of Mn and Fe in the leaf tissue close to toxicity levels. The findings suggest that inoculation with the PGPMs in combination with SC products (SP) can promote physiological stress adaptations and AM colonization to improve potato tuber yield, independent of effects on soil water retention. However, this does not apply to SC products in general.
Evidence of Clinical and Laboratory Correlation of Itraconazole Resistance in Sporothrix brasiliensis Infection: Case Report
Authors: Veasey John Verrinder , Reis Ana Paula Carvalho , Celestrino Giovanna Azevedo , Silva Camila Estacia , Santos Eduarda Souza , Mendes Denise Polizel , Andrade Tania Sueli , Bonfietti Lucas Xavier , Benard Gil , Sousa Maria Glória Texeira
Published: October 2024

Sporotrichosis is a subcutaneous infection caused by fungi from the genus Sporothrix, among which Sporothrix brasiliensis displays high virulence and transmissibility. So far, classical antifungal agents have been efficient against S. brasiliensis, but here we describe the first case of therapeutic failure and a high minimum inhibitory concentration (MIC) in relation to itraconazole.
The H–O–S Isotope Characteristics and Diagenetic, Mineralization Ages of the Zhueryu Au Deposit from the Jidong Gold Belt, China
Authors: Yang Wenjing , Cheng Tianshe , Zhang Xuebin , Guo Lijun , Gao Hongsheng , Duo Xingfang , Tu Lipeng , Zhang Xianzhen
Published: October 2024

The Zhueryu Au deposit is one of the important quartz-vein type Au deposits. It is located at the western margin of the Jidong gold belt in China and characterized by ore bodies hosted in structural fractures within the Zhueryu syenite. The H, O, and S isotopes as well as the Rb–Sr isotope age of fluid inclusions from the quartz-polymetallic sulfide ore bodies (main stage) and the zircon U–Pb isotope age from the syenite were analyzed so as to discuss the source of ore-forming fluids and constrain the Au’s mineralization age. The textural characteristics of the fluid inclusions indicate that the fluid inclusions in the quartz (QzII) are from the same stage, with no evidence of secondary fluid inclusions from the later stage. Fluid inclusion microthermometry performed on the quartz (QzII) reveals a predominance of vapor–liquid two-phase inclusions, with homogenization temperatures ranging from 177 °C to 337 °C (average: 260 °C), characteristic of a medium-low temperature hydrothermal system. Furthermore, H, O, and S isotope analyses of the ore-forming fluids yielded δD, δ18O, and δ34S values ranging from +12.8‰ to +14.8‰, +9.15‰ to +9.51‰, and −8.395‰ to -1.918‰ (average: −5.826‰), respectively. These isotopic signatures, particularly the distinctly positive δD values, strongly suggest that the Zhueryu ore-forming fluids were primarily derived from metamorphic sources, contrasting with the magmatic-hydrothermal fluids implicated in the formation of many other Au deposits within the Jidong belt. The LA–ICP–MS zircon U–Pb dating yielded a concordia age of 242 ± 2 Ma (MSWD = 0.17), indicating a Middle Triassic crystallization age for the Zhueryu syenite. In contrast, the Rb–Sr dating of primary fluid inclusions hosted within quartz (QzII) yielded an isochron age of 181 ± 12 Ma (MSWD = 2.5), placing the Au mineralization event firmly within the Early Jurassic. This demonstrates that the Au mineralization is significantly younger than the host syenite, representing a distinct mineralization event. These results might have certain significance for studying the dynamics of Au mineralization in the Jidong gold belt.
The Application of Sulfur–Metal Mass Ratios in Metal Sulfides in Assessing Prospects for Deep Metallogeny: A Case Study of the Tongshan Copper Deposit in Heilongjiang Province, Northeast China
Authors: Lan Ruixuan , Zhu Lixin , Tang Shixin , Duan Zhuang , Li Yong , Ma Shengming
Published: October 2024

Sulfur–metal mass ratios (SMMRs) between sulfur and metal elements (Cu, Pb, Zn, Ag, Fe, etc.) in metal sulfides are fixed in idealized compositions, so they should have a relatively fixed proportion in terms of mass without considering the presence of structural defects such as vacancies or substitution elements. Rock bodies with an SMMR of S far greater than the common metal sulfides may contain additional sulfides of other metals. We studied the Tongshan copper deposit in NE China and calculated the mass transfer of various elements in drill hole ZK611 samples. The data show a S influx of 7160 g/t, a Cu influx of 5469 g/t, and an Fe influx of 8796 g/t in the Cu ore body. Below the Cu ores, the average influx is 18,600 g/t of S, 650 g/t of Cu, and 5360 g/t of Fe, which provides an SMMR far above common mineral sulfide values. Further studies indicated that this rock unit contains fine-grained sphalerite and galenite, and when Zn and Pb are included in the rock SMMR calculations, values closer to the mineral sulfides emerge. These results imply that the coordinating balance relationship of S content with Fe and other ore-forming metals could provide direct information for assessing metallogenic prospects.
Correction: Xiong et al. Application of Multibody Dynamics and Bonded-Particle GPU Discrete Element Method in Modelling of a Gyratory Crusher. Minerals 2024, 14, 774
Authors: Xiong Youwei , Gan Jieqing , Chen Wei , Ou Tao , Zhao Guoyan , Wu Dongling
Published: October 2024

In the published article [...]
Adoption of Industry 4.0 Technologies in Chilean Mining: A Comparative Analysis Between Sectors
Authors: Castillo-Vergara Mauricio , Ortiz-Henríquez Rodrigo , Geldes Cristian , Muñoz-Cisterna Víctor , Escobar-Arriagada Claudio
Published: October 2024

Industry 4.0 represents a crucial technological revolution for the modernization and competitiveness of companies, offering tools that enhance the efficiency, productivity, and sustainability of industrial processes. Adopting these technologies is essential, especially in crucial sectors such as mining, where their implementation can radically transform operations. This study investigates the adoption of Industry 4.0 technologies among mining and non-mining companies in Chile, using data from the Survey of Access and Use of Information and Communication Technology in Companies. A Principal Component Analysis (PCA) identified the main variables influencing technological adoption. The results indicate that mining companies are significantly more advanced in integrating technologies such as ERP, SCM, and Big Data, which optimize their operational processes and strengthen their competitiveness. In contrast, non-mining companies show a more dispersed adoption, which could limit their capacity for innovation. These findings underscore the importance of developing differentiated public policies that promote technological adoption in SMEs and less advanced sectors, also encouraging the development of internal capacities and collaboration between businesses and government to accelerate digital transformation.
Synthesis of New Pyrazolo[3,4-d]pyrimidine Derivatives: NMR Spectroscopic Characterization, X-Ray, Hirshfeld Surface Analysis, DFT, Molecular Docking, and Antiproliferative Activity Investigations
Authors: El Hafi Mohamed , Anouar El Hassane , Lahmidi Sanae , Boulhaoua Mohammed , Loubidi Mohammed , Alanazi Ashwag S. , Filali Insaf , Hefnawy Mohamed , El Ghayati Lhoussaine , Mague Joel T. , Essassi El Mokhtar
Published: October 2024

Four new pyrazolo[3,4-d]pyrimidines (P1–P4) were successfully synthesized in good relative yields by reacting 3-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol with various alkylating agents (methyl iodide, propargyl bromide, and phenacyl bromide) at room temperature in DMF solvent, employing liquid–solid phase transfer catalysis. The P1–P4 structures were elucidated using NMR spectroscopy and X-ray diffraction. Intermolecular interactions in P1–P4 were analyzed via Hirshfeld surface analysis and 2D fingerprint plots. Geometrical parameters were accurately modeled by DFT calculations using the B3LYP hybrid functional combined with a 6–311++G(d,p) basis set. The antiproliferative activity of P1–P4 towards colorectal carcinoma (HCT 116), human hepatocellular carcinoma (HepG2), and human breast cancer (MCF-7) cell lines, along with one normal cell line (WI38) was investigated using the MTT assay and sunitinib as a reference. Compounds P1 and P2 exhibited antiproliferative activities comparable to the reference drug towards all tested cells, with an IC50 range of 22.7–40.75 µM. Both compounds also showed high selectivity indices and minimal cytotoxic effects on the normal cell line. Molecular docking revealed that the significant antiproliferative activity may attributed to the number and type of intermolecular hydrogen bonding established between pyrazolo[3,4-d]pyrimidines and DNA topoisomerase, a common target for various anticancer agents.
Electrochemical Sensing Strategies for Synthetic Orange Dyes
Authors: Wu Dihua , Zhu Jiangwei , Zheng Yuhong , Fu Li
Published: October 2024

This review explores electrochemical sensing strategies for synthetic orange dyes, addressing the growing need for sensitive and selective detection methods in various industries. We examine the fundamental principles underlying the electrochemical detection of these compounds, focusing on their redox behavior and interaction with electrode surfaces. The review covers a range of sensor designs, from unmodified electrodes to advanced nanomaterial-based platforms. Chemically modified electrodes incorporating polymers and molecularly imprinted polymers are discussed for their enhanced selectivity. Particular attention is given to nanomaterial-based sensors, including those utilizing carbon nanotubes, graphene derivatives, and metal nanoparticles, which have demonstrated exceptional sensitivity and wide linear ranges. The potential of biological-based approaches, such as DNA interaction sensors and immunosensors, is also evaluated. Current challenges in the field are addressed, including matrix effects in complex samples and long-term stability issues. Emerging trends are highlighted, including the development of multi-modal sensing platforms and the integration of artificial intelligence for data analysis. The review concludes by discussing the commercial potential of these sensors in food safety, environmental monitoring, and smart packaging applications, emphasizing their importance in ensuring the safe use of synthetic orange dyes across industries.
Design and Preparation of Heterostructured Cu2O/TiO2 Materials for Photocatalytic Applications
Authors: Tai Yating , Yang Boxuan , Li Jing , Meng Lingshi , Xing Pengcheng , Wang Shengjie
Published: October 2024

The extensive use of fossil fuels has sped up the global development of the world economy and is accompanied by significant problems, such as energy shortages and environmental pollution. Solar energy, an inexhaustible and clean energy resource, has emerged as a promising sustainable alternative. Light irradiation can be transformed into electrical/chemical energy, which can be used to remove pollutants or transform contaminants into high-value-added chemicals through photocatalytic reactions. Therefore, photocatalysis is a promising strategy to overcome the increasing energy and environmental problems. As is well-known, photocatalysts are key components of photocatalytic systems. Among the widely investigated photocatalysts, titanium dioxide (TiO2) has attracted great attention owing to its excellent light-driven redox capability and photochemical stability. However, its poor solar light response and rapid recombination of electron–hole pairs limit its photocatalytic applications. Therefore, strategies to enhance the photocatalytic activity of TiO2 by narrowing its bandgap and inhibiting the recombination of charges have been widely accepted. Constructing heterojunctions with other components, including cuprous oxide (Cu2O), has especially narrowed the bandgap, providing a promising means of solving the present challenges. This paper reviews the advances in research on heterostructured Cu2O/TiO2 photocatalysts, such as their synthesis methods, mechanisms for the enhancement of photocatalytic performance, and their applications in hydrogen production, CO2 reduction, selective synthesis, and the degradation of pollutants. The mechanism of charge separation and transfer through the Cu2O/TiO2 heterojunctions and the inherent factors that lead to the enhancement of photocatalytic performance are extensively discussed. Additionally, the current challenges in and future perspectives on the use of heterostructured Cu2O/TiO2 photocatalysts are also highlighted.
Methodology for Studying Hypothalamic Regulation of Feeding Behaviors
Authors: Davenport Julia B. , Güler Ali D. , Zhang Qi
Published: October 2024

Continuous advances in neurological research techniques are enabling researchers to further understand the neural mechanisms that regulate energy balance. In this review, we specifically highlight key tools and techniques and explore how they have been applied to study the role of the hypothalamic arcuate nucleus in feeding behaviors. Additionally, we provide a detailed discussion of the advantages and limitations associated with each methodology.
Fostering User Acceptance in Shared Autonomous Vehicles: A Framework for HMI Design
Authors: Yan Ming , Rampino Lucia , Caruso Giandomenico
Published: October 2024

The integration of automated vehicle (AV) technology in public transportation systems offers promising opportunities to improve the flexibility and safety of the traffic environment. However, user acceptance remains a critical challenge in the field of human-machine interaction for the effective deployment of shared autonomous vehicles (SAVs). This study presents a design framework aimed at enhancing user acceptance through human-machine interface (HMI) design tailored to SAVs. The framework is developed in adherence to relevant interaction design principles, following a systematic approach encompassing three key steps: analysis, synthesis, and evaluation. It integrates user acceptance factors into the design process, providing a structured method for designers. The framework was iteratively refined through interviews with three international domain experts; a focus group discussion with 10 researchers and professionals specializing in automotive interaction designers; and a workshop with 30 students and designers. The results demonstrate the framework’s ability to guide the development of user-acceptable HMI solutions. The paper concludes by emphasizing the need for further exploration into how user acceptance factors evolve over time and how real-world testing can validate the framework’s effectiveness in promoting user acceptance and satisfaction.
A Comparative Analysis of Folate and Mineral Contents in Freshly Squeezed and Commercial 100% Orange Juices Available in Europe
Authors: Cámara Montaña , Domínguez Laura , Medina Sonia , Mena Pedro , García-Viguera Cristina
Published: October 2024

Background: Orange juices are widely known for their organoleptic characteristics and potential health benefits derived from their nutritional and functional composition. Objectives: The aim of this work was to provide comprehensive, up-to-date information on the content of folates and some minerals (Ca, K, Mg, Fe, Mn, and Zn) present in different fresh and commercial orange juices available in the European market, including juices from concentrate (FC) and not from concentrate (NFC). Methods: A total of twenty-five juice samples were selected, comprising the most purchased types of commercial juices from France, the United Kingdom (UK), Germany, and Spain, and four fresh squeezed juices (FSJ) made from Spanish oranges. In FSJ, nutrient stability during storage time (0–48 h) was also assessed. Results: Folate concentration was highly variable between commercial samples, with higher contents in FSJ and NFC samples, followed by FC juices. Regarding mineral content, FSJ showed significant differences with FC (except for Mg) and NFC juice samples (except for Ca and Mg), while FC and NFC had similar mineral profiles, except for Ca. Storage time had no significant impact on FSJ folates and minerals. Conclusions: Among commercial juices, the NFC category generally showed the highest content of folates, K, Mg, and Fe, whereas FC juices showed the highest contents of Ca, Mn, and Zn. Some commercial juices met the legal use conditions for a “Source of folate” claim, whereas both commercial and fresh juices met the conditions for a “Source of potassium” claim, according to European and UK regulations.
A Perspective on the Interaction Between Recurrent Lower Urinary Tract Infections and Irritable Bowel Syndrome
Authors: Ruța Florina , Avram Calin , Mardale Elena , Pribac Mirela , Suciu Sara , Nyulas Victoria
Published: October 2024

Introduction: Given the potential overlap in risk factors associated with both irritable bowel syndrome (IBS) and lower urinary tract infections (LUTIs), we aimed to identify factors that may contribute to the development of both conditions, as well as recurrent lower urinary tract infections (RLUTIs). Our research also sought to explore overlapping symptoms and interactions between these two disorders. Materials and Methods: The study included young women with a history of urinary tract infections. Participants were divided into three groups: women with sporadic LUTIs (NRLUTIs), women with recurrent LUTIs (RLUTIs), and women with both a history of urinary infections (NRLUTI or RLUTI) and a diagnosis of IBS. The diagnosis of IBS is primarily clinical, relying on symptoms and the exclusion of other gastrointestinal disorders. Data from intestinal microbiota tests were combined with information on patients’ symptom perception, dietary habits, lifestyle, and knowledge regarding their conditions. Results: Abdominal pain, constipation, insufficient knowledge about antibiotic and probiotic use, and nutritionally unbalanced diets were identified as common factors associated with both LUTI-IBS and RLUTI. Conclusions: Our research identified shared risk factors between LUTI, IBS, and RLUTI, suggesting a pathological interdependence between these conditions. Notably, women with RLUTIs often experience gastrointestinal symptoms such as abdominal pain and constipation after consuming foods known to trigger IBS. This highlights that gut dysbiosis is both a risk factor and a potential consequence of RLUTI. The presence of either condition appears to exacerbate the symptoms of the other, further underscoring the intricate connection between RLUTI and IBS in affected individuals.
In Vitro Bioactivity of Australian Finger Lime Cultivars as an Initial Evaluation of Their Nutraceutical Potential
Authors: Johnson Joel B. , Thani Parbat Raj , Chen Si-Yuan , Mani Janice S. , Netzel Michael E. , Naiker Mani
Published: October 2024

There is increasing interest in Australian finger lime (Citrus australasica) due to its nutritional and bioactive potential. In this study, polar extracts from five finger lime cultivars were investigated for their potential bioactivity using a range of assays: antioxidant capacity (total phenolic content (TPC), ferric reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC)), total monomeric anthocyanin content (TMAC), anti-diabetic activity (α-glucosidase and α-amylase inhibition), anti-Alzheimer activity (acetylcholinesterase inhibition), Skin-whitening activity skin-brightening activity (tyrosinase inhibition), and anti-inflammatory activity (COX-2 inhibition). Commercial Tahitian lime was used as a “control” (comparison). The TPC ranged from 328 to 779 mg GAE/100 g dry weight (DW) in the pulp (compared to 1043 mg GAE/100 g for Tahitian lime) and from 755 to 1048 mg GAE/100 g in the peel (1704 mg GAE/100 g for Tahitian lime). A similar range of variation was seen for FRAP, ranging from 114 to 436 mg TE/100 g DW in the pulp (422 mg TE/100 g for Tahitian lime) and 259 to 495 mg TE/100 g DW in the peel (491 mg TE/100 g for Tahitian lime). Similarly, the TFC was generally lower in finger lime pulp (100–392 mg QE/100 g DW) compared to Tahitian lime (312 mg QE/100 g). The polar extracts did not show any significant inhibition of α-glucosidase, α-amylase, tyrosinase, or COX-2. One finger lime variety showed moderate (>50%) inhibition of acetylcholinesterase (AChE) at the highest concentration screened (~1500 mg/L), as did Tahitian lime. Additionally, in silico docking against acetylcholinesterase suggested that some of the polyphenols present, including catechin, quercetin-3-glucoside, and cyanidin-3-glucoside, could potentially dock to AChE and inhibit it. This is the first time the species has been investigated for many of these bioactive properties, and also the first time in silico docking has been performed to explore which potential compounds from this species could provide its bioactivity. Although little bioactivity was generally found across the applied bioassays, these findings nevertheless provide important basic data for future research and any claims about the potential health benefits of Australian finger lime.
Recent Developments Towards the Synthesis of Triazole Derivatives: A Review
Authors: Ameziane El Hassani Issam , Rouzi Khouloud , Ameziane El Hassani Anouar , Karrouchi Khalid , Ansar M’hammed
Published: October 2024

The triazole scaffold is a crucial component of heterocyclic chemistry, serving as a basic building block in organic synthesis, materials science, and medicinal chemistry. Triazole is a five-membered ring composed of three nitrogen atoms and two carbon atoms, and it exists in two isomeric forms: 1,2,3-triazole and 1,2,4-triazole. Compounds featuring the triazole ring are important heterocycles known for their diverse biological activities, including antimicrobial, antiproliferative, antimalarial, anticonvulsant, anti-inflammatory, antineoplastic, antiviral, analgesic, and anticancer properties. As a result, triazole derivatives have attracted significant attention from researchers. This review aims to provide a thorough overview of the published studies on the synthesis of triazole derivatives, highlighting various methods for obtaining the triazole moiety. These methods include classical approaches as well as microwave and ultrasound-assisted techniques.