bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the clinical utility of DPP-IV and SGLT2 inhibitors in papillary thyroid cancer: a literature review
Authors: Buczyńska Angelika , Kościuszko Maria , Krętowski Adam Jacek , Popławska-Kita Anna
Published: January 2024

In the realm of clinical management, Papillary Thyroid Cancer (PTC) stands out as a prevalent thyroid malignancy, characterized by significant metabolic challenges, particularly in the context of carbohydrate metabolism. Recent studies have unveiled promising applications of Dipeptidyl Peptidase-IV (DPP-IV) and Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors, which are conventionally employed in the treatment of type 2 diabetes mellitus (T2DM), as potential adjuncts in anticancer therapy. DPP-IV and SGLT2 inhibitors can be imply to counteract the Warburg effect in cancer, with a specific focus on PTC, owing to their potential metabolic advantages and their influence on the tumor microenvironment, achieved by imposing restrictions on glucose accessibility. Consequently, a comprehensive review has been undertaken, involving meticulous examination of the existing body of evidence pertaining to the utilization of DPP-IV and SGLT2 inhibitors in the context of PTC. The mechanisms of action inherent to these inhibitors have been thoroughly explored, drawing upon insights derived from preclinical investigations. Furthermore, this review initiates discussions concerning the implications for future research directions and the formulation of innovative therapeutic strategies for PTC. As the intricate interplay between carbohydrate metabolism, the Warburg effect, and cancer progression garners increasing attention, attaining a comprehensive understanding of the roles played by DPP-IV and SGLT2 inhibitors in PTC management may serve as the cornerstone for novel approaches aimed at enhancing patient care and broadening the spectrum of available therapeutic modalities.
Spontaneous bodily coordination varies across affective and intellectual child-adult interactions
Authors: Cornejo Carlos , Cuadros Zamara , Carré David , Hurtado Esteban , Olivares Himmbler
Published: January 2024

Research on child-adult interactions has identified that the morphology of bodily coordination seems to be sensitive to age and type of interaction. Mirror-like imitation emerges earlier in life and is more common during emotionally laden interactions, while anatomical imitation is acquired later and associated with cognitive tasks. However, it remains unclear whether these morphologies also vary with age and type of interaction during spontaneous coordination. Here we report a motion capture study comparing the spontaneous coordination patterns of thirty-five 3-year-old (20 girls; Mage = 3.15 years) and forty 6-year-old children (20 girls; Mage = 6.13 years) interacting with unacquainted adults during two storytelling sessions. The stories narrated the search of a character for her mother (Predominantly Affective Condition) or an object (Predominantly Intellectual Condition) inside a supermarket. Results show that children of both ages consistently coordinated their spontaneous movements towards adult storytellers, both in symmetric and asymmetric ways. However, symmetric coordination was more prominent in 3-year-old children and during predominantly emotional interactions, whereas asymmetric coordination prevailed in 6-year-old children and during predominantly intellectual interactions. These results add evidence from spontaneous interactions in favor of the hypothesis that symmetric coordination is associated with affective interactions and asymmetric coordination with intellectual ones.
Influence of care modes and social resources on psychotropic medication use in community-dwelling dementia patients
Authors: Chan Wei-Chieh , Wang Wen-Fu , Tung Yu-Chun , Chang Ming-Che , Chan Hong-Ting , Jhang Kai-Ming
Published: January 2024

Background

Optimal use of psychotropic medications for people living with dementia is important. By finding potentially modifiable factors, dementia care teams may find solutions to achieve the appropriate use of psychotropic drugs.

Objective

This study aimed to elucidate patient and caregiver factors associated with the use of psychotropic drugs listed in the potentially inappropriate medications (PIMs) in community-dwelling people with dementia.

Methods

This cross-sectional study enrolled 808 patients newly diagnosed with dementia, and their caregivers, from a dementia clinic at Changhua Christian Hospital. Patient and caregiver characteristics, care mode, and social resource usage were recorded. Multivariate logistic regression was used to identify factors associated with prescribing psychotropic medications.

Results

Of all the participants, 39.1% used at least one of psychotropic medication categorized as PIM. Patients with frontotemporal dementia, with behavior or psychological symptoms, or cared by sole foreign care workers; caregivers with higher depression scores, employed or non-spouse caregivers carried a higher risk of prescription of psychotropic medications listed in PIMs.

Conclusion

Psychotropic drug prescriptions are associated with patient and caregiver factors. Therefore, implementing appropriate interventions, especially those targeting potentially modifiable factors, is important to reduce psychotropic medication use.
Lifespan adversities affect neural correlates of behavioral inhibition in adults
Authors: Sacu Seda , Aggensteiner Pascal-M. , Monninger Maximilian , Kaiser Anna , Brandeis Daniel , Banaschewski Tobias , Holz Nathalie E.
Published: January 2024

Introduction

Growing evidence suggests that adverse experiences have long-term effects on executive functioning and underlying neural circuits. Previous work has identified functional abnormalities during inhibitory control in frontal brain regions in individuals exposed to adversities. However, these findings were mostly limited to specific adversity types such as maltreatment and prenatal substance abuse.

Methods

We used data from a longitudinal birth cohort study (n = 121, 70 females) to investigate the association between adversities and brain responses during inhibitory control. At the age of 33 years, all participants completed a stop-signal task during fMRI and an Adult Self-Report scale. We collected seven prenatal and postnatal adversity measures across development and performed a principal component analysis to capture common variations across those adversities, which resulted in a three-factor solution. Multiple regression analysis was performed to identify links between adversities and brain responses during inhibitory control using the identified adversity factors to show the common effect and single adversity measures to show the specific contribution of each adversity. To find neural correlates of current psychopathology during inhibitory control, we performed additional regression analyses using Adult Self-Report subscales.

Results

The first adversity factor reflecting prenatal maternal smoking and postnatal psychosocial adversities was related to higher activation during inhibitory control in bilateral inferior frontal gyri, insula, anterior cingulate cortex, and middle temporal gyri. Similar results were found for the specific contribution of the adversities linked to the first adversity factor. In contrast, we did not identify any significant association between brain responses during inhibitory control and the second adversity factor reflecting prenatal maternal stress and obstetric risk or the third adversity factor reflecting lower maternal sensitivity. Higher current depressive symptoms were associated with higher activation in the bilateral insula and anterior cingulate cortex during inhibitory control.

Conclusion

Our findings extended previous work and showed that early adverse experiences have a long-term effect on the neural circuitry of inhibitory control in adulthood. Furthermore, the overlap between neural correlates of adversity and depressive symptomatology suggests that adverse experiences might increase vulnerability via neural alterations, which needs to be investigated by future longitudinal research.
Parental occupations at birth and risk of adult testicular germ cell tumors in offspring: a French nationwide case–control study
Authors: Paul Adèle , Danjou Aurélie M. N. , Deygas Floriane , Guth Margot , Coste Astrid , Lefevre Marie , Dananché Brigitte , Kromhout Hans , Spinosi Johan , Béranger Rémi , Pérol Olivia , Boyle Helen , Hersant Christel , Loup-Cabaniols Vanessa , Veau Ségolène , Bujan Louis , Olsson Ann , Schüz Joachim , Fervers Béatrice , Charbotel Barbara
Published: January 2024

Background

Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT.

Methods

A case–control study was conducted, including 454 TGCT cases aged 18–45 from 20 French university hospitals, matched to 670 controls based on region and year of birth. Data collected from participants included parental jobs at birth coded according to the International Standard Classification of Occupation—1968 and the French nomenclature of activities—1999. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors.

Results

Paternal jobs at birth as service workers (OR = 1.98, CI 1.18–3.30), protective service workers (OR = 2.40, CI 1.20–4.81), transport equipment operators (OR = 1.96, CI 1.14–3.37), specialized farmers (OR = 2.66, CI 1.03–6.90), and maternal jobs as secondary education teachers (OR = 2.27, CI 1.09–4.76) or in secondary education (OR = 2.35, CI 1.13–4.88) were significantly associated with adult TGCT. The risk of seminoma was increased for the above-mentioned paternal jobs and that of non-seminomas for public administration and defence; compulsory social security (OR = 1.99, CI 1.09–3.65); general, economic, and social administration (OR = 3.21, CI 1.23–8.39) for fathers; and secondary education teacher (OR = 4.67, CI 1.87–11.67) and secondary education (OR = 3.50, CI 1.36–9.01) for mothers.

Conclusion

Some paternal jobs, such as service workers, transport equipment operators, or specialized farmers, and maternal jobs in secondary education seem to be associated with an increased risk of TGCT with specific features depending on the histological type. These data allow hypotheses to be put forward for further studies as to the involvement of occupational exposures in the risk of developing TGCT, such as exposure to pesticides, solvents, or heavy metals.
The Family-Check-Up® Autism Implementation Research (FAIR) Study: protocol for a study evaluating the effectiveness and implementation of a family-centered intervention within a Canadian autism service setting
Authors: Bennett Teresa , Drmic Irene , Gross Julie , Jambon Marc , Kimber Melissa , Zaidman-Zait Anat , Andrews K. , Frei Julia , Duku E. , Georgiades Stelios , Gonzalez Andrea , Janus Magdalena , Lipman E. , Pires Paulo , Prime Heather , Roncadin Caroline , Salt Mackenzie , Shine Rebecca
Published: January 2024

Introduction

Prevalence rates of emotional and behavior problems (EBP) in autistic children and youth are high (40–70%), and often cause severe and chronic impairment. Furthermore, autistic children are also more likely to experience family “social-ecological” adversity compared to neurotypically developing peers, including social isolation, child maltreatment, caregiver mental illness, and socioeconomic risk. These family stressors increase the risk of co-occurring EBP among autistic children and can often impede access to evidence-based care, thus amplifying long-term health inequities for autistic children and their caregivers. In the current autism services landscape, there are few scalable, evidence-based programs that adequately address these needs. TheFamily Check-Up (FCU®)is a brief, strength-based, and tailored family-centered intervention that supports positive parenting and explicitly assesses the social determinants of child and family mental health within an ecological framework. Studies have demonstrated long-term positive child and caregiver outcomes in other populations, but the FCU® has not been evaluated in families of autistic children and youth. Therefore, we aimed to evaluate FCU® implementation within an established, publicly funded Autism Program in Ontario, Canada, with delivery by autism therapists, to demonstrate sustainable effectiveness within real-world settings.

Methods

In this study, we outline the protocol for a hybrid implementation-effectiveness approach with two key components: (1) A parallel-arm randomized controlled trial ofN= 80 autistic children/youth (ages 6–17 years) and high levels of EBP and their caregivers. Primary and secondary outcomes include child EBP, and caregiver well-being and parenting. (2) A mixed methods implementation study, to describe facilitators and barriers to implementation of the FCU® within an autism service setting.

Discussion

Scalable, ecologically focused family-centered interventions offer promise as key components of a public health framework aimed at reducing mental health inequities among autistic children, youth, and their caregivers. Results of this study will inform further program refinement and scale-up.
The good bank: preference of banking institutions based on perceptions of corporate environmental and social causes
Authors: Gaspar Augusta D. , Pinto Joana Carneiro
Published: January 2024

Introduction

This study aims to contribute to understanding factors that explain consumers' preferences for banking institutions. We specifically explored the roles of Corporate Social Responsibility (CSR)—targeted primarily at Environmental causes and secondarily at Social causes—on corporate image (CI), consumer satisfaction (CS) and consumer loyalty (CL). We tested whether integrating a CSR description with an emphasis on environmental causes into the bank marketing strategy would positively affect CI, CS and CL. We also inspected the effect of online banking vs. direct human contact, and perception of price fairness, as well as that of the consumers' demographic variables.

Methods

A survey was carried out online, with 322 international respondents recruited through social networks. Participants were randomly directed to one of eight different bank conditions, each combining descriptions where Environmental and social CSR, Price fairness, and direct human contact with the clients varied. After reading the bank description participants filled out a questionnaire that addressed their perception of the bank's CI and their projections of CS and CL.

Results and discussion

Results indicated that participants favored the banks that included CSR as part of their description, with the perception of price fairness being the second critical factor in the respondents' CI, CS, and CL. Direct human contact vs. remote banking did not play a role in the participant's ratings of the bank, which is in line with more current studies. We concluded that businesses in the banking sector enhance their global reputation when investing in environmental and social CSR.
Crop diversification, land price spillovers, and land governance: evidence from China
Authors: Liu Yu , Wang Shangao , Zhu Honggen , Wang Yue
Published: January 2024

Introduction

Crop diversification from grain to non-grain production is often considered a threat to food security in many populous countries with limited arable land. Yet its potential spillover effect has not been fully studied. This study explores a unique plot-level dataset to particularly quantify the spillover effect of non-grain production on the land rental price of grain production from the perspective of factor opportunity cost and proposes corresponding land management strategies.

Methods

Data used in this study came from a field survey conducted in Jiangsu province. OLS method was employed to test the effect of non-grain production on the rent price of grain production farmland, combined with plot-level heterogeneity analysis. In addition, Quantile method was used for robustness check.

Results

Our main finding indicates that converting land use from grain production to non-grain production significantly increases the land rental rate of surrounding plots for grain production by 222.02 yuan/mu, accounting for 28.75% of the total land rent (772.25 yuan/mu). This spillover effect exhibits a stronger trend as the contracted land scale expands. However, the kin relationship among contract parties can weaken this effect, indicating that social ties can work as a mediator in offsetting the negative shock of the rental rate increase due to non-grain production. In order to keep the land rent under control, rural land use is actively harnessed by local governments at a guided price.

Discussion

Based on the empirical results, the study recommends comprehensive land use planning and a regionally regulated land transfer market in order to achieve a balance between food security and a diversified agricultural structure.
Escherichia coli adapts metabolically to 6- and 7-fluoroindole, enabling proteome-wide fluorotryptophan substitution
Authors: Treiber-Kleinke Christin , Berger Allison Ann , Adrian Lorenz , Budisa Nediljko , Koksch Beate
Published: January 2024

Nature has scarcely evolved a biochemistry around fluorine. However, modern science has shown that fluorinated organic molecules are suitable building blocks for biopolymers, from peptides and proteins up to entire organisms. Here, we conducted adaptive laboratory evolution (ALE) experiments to introduce organofluorine into living microorganisms. By cultivating Escherichia coli with fluorinated indole analogs, we successfully evolved microbial cells capable of utilizing either 6-fluoroindole or 7-fluoroindole for growth. Our improved ALE protocols enabled us to overcome previous challenges and adaptation was achieved, enabling a former growth inhibiting unnatural molecule to become a substrate for the cell’s protein synthesis machinery to the extent that the entire proteome underwent Trp to F-Trp substitution. In the ALE experiments, we supplied fluoroindoles to Trp-auxotrophic E. coli bacteria, exerting strong selective pressure that led to microbial adaptation. Within the cells, these indoles were converted into the corresponding amino acids (6- and 7-fluorotryptophan) and globally incorporated into the proteome at tryptophan sites. This study is a first step and establishes a strong foundation for further exploration of the mechanisms underlying fluorine-based life and how a former antimetabolite can become a vital nutrient.
Incidence of concurrent systemic injuries with traumatic proptosis and its effect on outcome – 100 dogs
Authors: Whinery Nicole , Allbaugh Rachel A. , Sebbag Lionel , Walton Rebecca
Published: January 2024

Objective

To evaluate the incidence of concurrent systemic injuries in dogs with traumatic ocular proptosis and their effect on survival to discharge. Additionally, to evaluate for associations between the type of trauma, each presenting vital signs, minimum laboratory database findings including packed cell volume, total solids, plasma glucose and lactate concentrations, and the diagnosis of concurrent systemic injury and survival.

Design

Retrospective study between the years 2017 and 2022.

Setting

One university teaching hospital and one large, private practice.

Animals

One hundred dogs presenting to the hospital with a diagnosis of traumatic ocular proptosis.

Measurements and main results

Medical records were retrospectively reviewed; signalment, breed, sex, age, weight, date of presentation, type of trauma sustained, time from trauma to presentation, vitals on presentation, and minimum laboratory database findings including packed cell volume (PCV), total solids (TS), plasma glucose concentration, and plasma lactate concentration were recorded. A modified animal trauma triage (ATT) score was retrospectively calculated. A total of 17 dogs (17%) had concurrent systemic injury. Compared to dogs without systemic injuries, dogs with systemic injuries had a significantly lower body temperature [median 101.1F (38.3C) vs. 101.6F (38.6C); P = 0.008], significantly higher plasma glucose concentrations (125 mg/dL, 6.9 mmol/L vs. 112 mg/dL, 6.2 mmol/L; P = 0.012) and approaching statistical significance, lower PCV values (median 40 vs. 46%; P = 0.051).

Conclusions

Dogs presenting with traumatic ocular proptosis do present with concurrent systemic, non-ocular injuries; however, these concurrent injuries do not seem to be associated with survival to discharge.
The BAR Score Predicts and Stratifies Outcomes Following Liver Retransplantation: Insights From a Retrospective Cohort Study
Authors: Krendl Felix J. , Fodor Margot , Buch Madita L. , Singh Jessica , Esser Hannah , Cardini Benno , Resch Thomas , Maglione Manuel , Margreiter Christian , Schlosser Lisa , Hell Tobias , Schaefer Benedikt , Zoller Heinz , Tilg Herbert , Schneeberger Stefan , Oberhuber Rupert
Published: January 2024

Liver retransplantation (reLT) yields poorer outcomes than primary liver transplantation, necessitating careful patient selection to avoid futile reLT. We conducted a retrospective analysis to assess reLT outcomes and identify associated risk factors. All adult patients who underwent a first reLT at the Medical University of Innsbruck from 2000 to 2021 (N = 111) were included. Graft- and patient survival were assessed via Kaplan-Meier plots and log-rank tests. Uni- and multivariate analyses were performed to identify independent predictors of graft loss. Five-year graft- and patient survival rates were 64.9% and 67.6%, respectively. The balance of risk (BAR) score was found to correlate with and be predictive of graft loss and patient death. The BAR score also predicted sepsis (AUC 0.676) and major complications (AUC 0.720). Multivariate Cox regression analysis identified sepsis [HR 5.179 (95% CI 2.575–10.417), p < 0.001] as the most significant independent risk factor for graft loss. At a cutoff of 18 points, the 5 year graft survival rate fell below 50%. The BAR score, a simple and easy to use score available at the time of organ acceptance, predicts and stratifies clinically relevant outcomes following reLT and may aid in clinical decision-making.
Reducing Q-Value Estimation Bias via Mutual Estimation and Softmax Operation in MADRL
Authors: Li Zheng , Chen Xinkai , Fu Jiaqing , Xie Ning , Zhao Tingting
Published: January 2024

With the development of electronic game technology, the content of electronic games presents a larger number of units, richer unit attributes, more complex game mechanisms, and more diverse team strategies. Multi-agent deep reinforcement learning shines brightly in this type of team electronic game, achieving results that surpass professional human players. Reinforcement learning algorithms based on Q-value estimation often suffer from Q-value overestimation, which may seriously affect the performance of AI in multi-agent scenarios. We propose a multi-agent mutual evaluation method and a multi-agent softmax method to reduce the estimation bias of Q values in multi-agent scenarios, and have tested them in both the particle multi-agent environment and the multi-agent tank environment we constructed. The multi-agent tank environment we have built has achieved a good balance between experimental verification efficiency and multi-agent game task simulation. It can be easily extended for different multi-agent cooperation or competition tasks. We hope that it can be promoted in the research of multi-agent deep reinforcement learning.
Corporate Social Responsibility and Financial Performance: A Relationship Mediated by Stakeholder Satisfaction
Authors: Licandro Oscar , Burguete José Luis Vázquez , Ortigueira-Sánchez Luis Camilo , Correa Patricia
Published: January 2024

Research work on the relationship between Corporate Social Responsibility and financial performance has been going on for seven decades. Even when the prevailing studies are those that found a positive influence of social responsibility on financial performance, strong conclusive results are still unavailable. Some explanations for this situation are based, among other reasons, on the fact that the variables have a relation mediated by multiple factors. Additionally, it is still unknown whether the results obtained can be extrapolated to all types of companies since the majority of studies have focused on large companies listed on the stock exchange. This research studied how one of those factors (stakeholder satisfaction) mediated in companies of different sizes (including SMEs) and different types of companies (publicly listed companies or private ownership companies). A questionnaire was used, including indices relative to (1) the degree of development of the company’s social responsibility policies, (2) the changes in the satisfaction of four key stakeholders (employees, customers, suppliers, and shareholders) and financial performance (sales and profitability). Findings show the existence of a correlation between social responsibility and financial performance and also that such a relationship is mediated by the satisfaction of stakeholders. That relationship was also found to be independent of company sizes and the type of company This research work is intended to be a contribution towards that field of study, as it has detected a relationship between variables in medium-sized and private ownership companies.
Enhancing RDX Thermal Decomposition in Al@RDX Composites with Co Transition Metal Interfacial Layer
Authors: Yang Su-Lan , Xie Kan , Wang Jing , An Bingchen , Tian Bin , Nie Hongqi , Lyu Jie-Yao , Yan Qi-Long
Published: January 2024

In this study, an Al/Co@RDX composite was meticulously prepared through a combination of planetary high-energy ball-milling and a spray-drying technique. The thermal reactivity of these Al/Co@RDX composites was comprehensively investigated and compared using the TG/DSC technique. It is shown that the initial decomposition temperature of RDX in the DSC curve was decreased by 26.3 °C in the presence of Al/Co, which could be attributed to the nano-sized Co transition metal catalyzing the decomposition reaction of nitrogen oxides in RDX decomposition products. The decomposition peak temperature of RDX and the heat released by the thermal decomposition of RDX in the Al/Co@RDX composite were decreased by 26.3 °C and increased by 74.5 J·g−1, respectively, in comparison with those of pure RDX. The types of major gaseous products released from Al/Co@RDX were found to be identical to those of pure RDX, encompassing N2O, CH2O, CO2 and HCN. However, the concentrations of those gaseous products for Al/Co@RDX were higher than those observed for pure RDX, which may owe to the fact that the Al/Co composite can interact with the –CH2 and –NO2 within RDX molecules, which leads to the weakening of the C-N and N-N bonds. In addition, the decomposition of RDX in the Al/Co@RDX composite was observed as a one-step process with an apparent activation energy (Ea) of 115.6 kJ·cm−3. The decomposition mechanism of the RDX in the Al/Co@RDX composite was identified to follow the chain scission model (L2), whereas the two-step decomposition physical models observed for pure RDX were found to closely resemble the L2 and autocatalytic models.
Recent Mass Balance Anomalies on the Djankuat Glacier, Northern Caucasus
Authors: Popovnin Victor , Gubanov Afanasiy , Lisak Valentina , Toropov Pavel
Published: January 2024

A 54-year-long series of continuous instrumental measurements of mass balance and its main components has already been accumulated at the Djankuat Glacier, which is representative of the Caucasus and the most studied glacier in Russia. The anomalies of these indicators in 2017/2018–2020/2021 were evaluated against an analysis of meteorological reasons that predetermined them. Each of the four balance years under consideration represents a particular anomaly of varying severity. As for conditions of mass income, three years saw accumulation higher than average, and in one year (2018/2019) it approached the norm. As for summer ablation conditions, similarly, in one season (2019) the melting differed from the average only slightly, but in the other three it was much higher. Consequently, in one year (2020/2021) the state of the glacier was close to normal, in another (2017/2018) the budget situation was much more favorable for Djankuat, and in the other two the final losses significantly exceeded the average annual mass loss rate. At the same time, in 2019/2020, an absolute record of ablation since the beginning of monitoring in 1967/1968 was recorded (4360 mm w.e.). Nevertheless, although negative mass balance values continue to be recorded annually, signs of an inevitable slowdown in the rate of glacier degradation in the Caucasus have appeared in the last 4-year-long period: the continued growth of winter snow accumulation overlaps the ongoing intensification of summer melting. The growth of debris cover in terms of area and thickness also affects this mass loss slowdown to some extent. This inhibits ablation, exerting a heat-insulating effect. Because of this, the congruence of mass balance parameters vs. altitude curves is distorted. Also, a tendency toward increasing annual glacier mass turnover was revealed for the last half-century. This fact gradually increases the energy of glaciation and indirectly indicates a weakening of continentality in the climate of the Caucasian highlands.
Particulate Matter in the American Southwest: Detection and Analysis of Dust Storms Using Surface Measurements and Ground-Based LIDAR
Authors: Guzman-Gonzalez Joscelyne , Fitzgerald Rosa M. , Karle Nakul N. , Sakai Ricardo K. , Stockwell William R.
Published: January 2024

This research study focuses on the coupling between particulate matter and the planetary boundary layer. Particulate matter affects human health and it is a complex mixture of suspended substances. Various sources of particulate matter include volcanic eruptions, soil lofted by strong winds, wildfires, and particles formed from chemical reactions of gas-phase emissions. Strong winds are one source of dust pollution when they loft soil particles. Particulate matter and the planetary boundary layer are closely linked. The planetary boundary layer plays a critical role in meteorology and particulate matter concentrations due to its involvement in energy, latent heat, and mass transfer with the free troposphere. Currently, there has been no research on the impact of dust events on the planetary boundary layer in our region, El Paso, Texas, which is located on one of the biggest sources of dust in the Western Hemisphere, the Chihuahuan Desert. In this study, we used PM10 concentrations to detect dust events during the 2016–2022 period in the El Paso region. During the study period, we observed 74 dust events. The dust events were categorized as synoptic or convective cases. Synoptic cases are associated with cold fronts, while convective cases are associated with local convective systems such as thunderstorms. We observed that synoptic cases occurred most frequently during springtime, while convective cases were more frequent during summer monsoon months. Synoptic cases tend to occur earlier in the afternoon with lower temperatures, while convective cases tend to occur in the late evening with higher temperatures. We also found that the planetary boundary layer height collapsed after the maximum hourly PM10 concentration and then the boundary layer returned to its original height.
Evaluating the Robustness of Deep Learning Models against Adversarial Attacks: An Analysis with FGSM, PGD and CW
Authors: Villegas-Ch William , Jaramillo-Alcázar Angel , Luján-Mora Sergio
Published: January 2024

This study evaluated the generation of adversarial examples and the subsequent robustness of an image classification model. The attacks were performed using the Fast Gradient Sign method, the Projected Gradient Descent method, and the Carlini and Wagner attack to perturb the original images and analyze their impact on the model’s classification accuracy. Additionally, image manipulation techniques were investigated as defensive measures against adversarial attacks. The results highlighted the model’s vulnerability to conflicting examples: the Fast Gradient Signed Method effectively altered the original classifications, while the Carlini and Wagner method proved less effective. Promising approaches such as noise reduction, image compression, and Gaussian blurring were presented as effective countermeasures. These findings underscore the importance of addressing the vulnerability of machine learning models and the need to develop robust defenses against adversarial examples. This article emphasizes the urgency of addressing the threat posed by harmful standards in machine learning models, highlighting the relevance of implementing effective countermeasures and image manipulation techniques to mitigate the effects of adversarial attacks. These efforts are crucial to safeguarding model integrity and trust in an environment marked by constantly evolving hostile threats. An average 25% decrease in accuracy was observed for the VGG16 model when exposed to the Fast Gradient Signed Method and Projected Gradient Descent attacks, and an even more significant 35% decrease with the Carlini and Wagner method.
Enzymatically Driven Mineralization of a Calcium–Polyphosphate Bleaching Gel
Authors: Ortiz Mariangela Ivette Guanipa , Corrales Ureña Yendry Regina , Aguiar Flávio Henrique Baggio , Lima Débora Alves Nunes Leite , Rischka Klaus
Published: January 2024

To examined alkaline phosphatase enzyme (ALP) activity and the effects of incorporating it in the thickener solution of a hydrogen-peroxide-based bleaching gel containing calcium-polyphosphate (CaPP) on the orthophosphate (PO43−) levels, bleaching effectiveness, and enamel microhardness. ALP activity was assessed at different pH levels and H2O2 concentrations, and in H2O- and Tris-based thickeners. Circular dichroism (CD) was used to examine the ALP secondary structure in water-, Tris-, or H2O2-based mediums. The PO43− levels were evaluated in thickeners with and without ALP. Enamel/dentin specimens were allocated into the following groups: control (without bleaching); commercial (Whiteness-HP-Maxx); Exp-H (H2O-based); CaPP-H; ALP-H (CaPP+ALP); Exp-T (Tris-based); CaPP-T; and ALP-T (CaPP+ALP). Color changes (ΔE/ΔE00) and the bleaching index (ΔWID) were calculated, and surface (SMH) and cross-sectional microhardness (CSMH) were assessed. The two-way ANOVA and Tukey’s post-hoc tests were used to compare ALP and PO43− levels; generalized linear models were used to examine: ΔE/ΔE00/SMH/CSMH; and Kruskal–Wallis and Dunn’s tests were used for ΔWID (α = 5%). The ALP activity was higher at pH 9, lower in H2O2-based mediums, and similar in both thickeners. The CD-spectra indicated denaturation of the enzyme upon contact with H2O2. The PO43− levels were higher after incorporating ALP, and the ΔE/ΔE00/ΔWID were comparable among bleached groups. SMH was lower after bleaching in Exp-H, while CSMH was highest in ALP-T.
A Novel Druggable Dual-Specificity tYrosine-Regulated Kinase3/Calmodulin Kinase-like Vesicle-Associated Signaling Module with Therapeutic Implications in Neuroblastoma
Authors: Rozen Esteban J. , Wigglesworth Kim , Shohet Jason M.
Published: January 2024

High-risk neuroblastoma is a very aggressive pediatric cancer, accounting for ~15% of childhood cancer mortality. Therefore, novel therapeutic strategies for the treatment of neuroblastoma are urgently sought. Here, we focused on the potential implications of the Dual-specificity tYrosine-Regulated Kinase (DYRK) family and downstream signaling pathways. We used bioinformatic analysis of public datasets from neuroblastoma cohorts and cell lines to search correlations between patient survival and expression of DYRK kinases. Additionally, we performed biochemical, molecular, and cellular approaches to validate and characterize our observations, as well as an in vivo orthotopic murine model of neuroblastoma. We identified the DYRK3 kinase as a critical mediator of neuroblastoma cell proliferation and in vivo tumor growth. DYRK3 has recently emerged as a key regulator of several biomolecular condensates and has been linked to the hypoxic response of neuroblastoma cells. Our data suggest a role for DYRK3 as a regulator of the neuroblastoma-specific protein CAMKV, which is also required for neuroblastoma cell proliferation. CAMKV is a very understudied member of the Ca2+/calmodulin-dependent protein kinase family, originally described as a pseudokinase. We show that CAMKV is phosphorylated by DYRK3, and that inhibition of DYRK3 kinase activity induces CAMKV aggregation, probably mediated by its highly disordered C-terminal half. Importantly, we provide evidence that the DYRK3/CAMKV signaling module could play an important role for the function of the mitotic spindle during cell division. Our data strongly support the idea that inhibition of DYRK3 and/or CAMKV in neuroblastoma cells could constitute an innovative and highly specific intervention to fight against this dreadful cancer.
Aptamer-Based Switching System for Communication of Non-Interacting Proteins
Authors: Kim Younghyeon , Nam Daehan , Lee Eun Sung , Kim Seokjoon , Cha Byung Seok , Park Ki Soo
Published: January 2024

Biological macromolecules, such as DNA, RNA, and proteins in living organisms, form an intricate network that plays a key role in many biological processes. Many attempts have been made to build new networks by connecting non-communicable proteins with network mediators, especially using antibodies. In this study, we devised an aptamer-based switching system that enables communication between non-interacting proteins. As a proof of concept, two proteins, Cas13a and T7 RNA polymerase (T7 RNAP), were rationally connected using an aptamer that specifically binds to T7 RNAP. The proposed switching system can be modulated in both signal-on and signal-off manners and its responsiveness to the target activator can be controlled by adjusting the reaction time. This study paves the way for the expansion of biological networks by mediating interactions between proteins using aptamers.
Effects of Perceived Parent–Child Relationships and Self-Concept on Creative Personality among Middle School Students
Authors: Park Hyesung , Kim Sungyeun
Published: January 2024

This study investigated the impact of perceived parent–child relationships on creative personality in middle school students according to self-concept, focusing on environmental (parent–child relationships) and individual (self-concept) factors that can influence these students’ creative personalities. To this end, this study verified the moderation effect using sixth-year data (third year of middle school students) from the Seoul Longitudinal Educational Study 2010 Panel, utilizing SPSS 26.0 and the PROCESS macro. The results revealed that the self-concept of middle school students moderated the influence of parent–child relationships on creative personality. Specifically, it was found that as the level of self-concept increased above the average the positive relationship between parent–child relationships and creative personality strengthened. Based on the study’s findings, theoretical and practical suggestions for creating a home and educational environment to promote creativity during adolescence were discussed.
Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human
Authors: Tewari Manju , Michalski Stephanie , Egan Terrance M.
Published: January 2024

P2X receptors are a family of seven ATP-gated ion channels that trigger physiological and pathophysiological responses in a variety of cells. Five of the family members are sensitive to low concentrations of extracellular ATP, while the P2X6 receptor has an unknown affinity. The last subtype, the P2X7 receptor, is unique in requiring millimolar concentrations to fully activate in humans. This low sensitivity imparts the agonist with the ability to act as a damage-associated molecular pattern that triggers the innate immune response in response to the elevated levels of extracellular ATP that accompany inflammation and tissue damage. In this review, we focus on microglia because they are the primary immune cells of the central nervous system, and they activate in response to ATP or its synthetic analog, BzATP. We start by introducing purinergic receptors and then briefly consider the roles that microglia play in neurodevelopment and disease by referencing both original works and relevant reviews. Next, we move to the role of extracellular ATP and P2X receptors in initiating and/or modulating innate immunity in the central nervous system. While most of the data that we review involve work on mice and rats, we highlight human studies of P2X7R whenever possible.
Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation
Authors: Cenni Vittoria , Evangelisti Camilla , Santi Spartaco , Sabatelli Patrizia , Neri Simona , Cavallo Marco , Lattanzi Giovanna , Mattioli Elisabetta
Published: January 2024

In muscle cells subjected to mechanical stimulation, LINC complex and cytoskeletal proteins are basic to preserve cellular architecture and maintain nuclei orientation and positioning. In this context, the role of lamin A/C remains mostly elusive. This study demonstrates that in human myoblasts subjected to mechanical stretching, lamin A/C recruits desmin and plectin to the nuclear periphery, allowing a proper spatial orientation of the nuclei. Interestingly, in Emery-Dreifuss Muscular Dystrophy (EDMD2) myoblasts exposed to mechanical stretching, the recruitment of desmin and plectin to the nucleus and nuclear orientation were impaired, suggesting that a functional lamin A/C is crucial for the response to mechanical strain. While describing a new mechanism of action headed by lamin A/C, these findings show a structural alteration that could be involved in the onset of the muscle defects observed in muscular laminopathies.
Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications
Authors: Volatier Thomas , Cursiefen Claus , Notara Maria
Published: January 2024

Corneal stromal stem cells (CSSCs) are of particular interest in regenerative ophthalmology, offering a new therapeutic target for corneal injuries and diseases. This review provides a comprehensive examination of CSSCs, exploring their anatomy, functions, and role in maintaining corneal integrity. Molecular markers, wound healing mechanisms, and potential therapeutic applications are discussed. Global corneal blindness, especially in more resource-limited regions, underscores the need for innovative solutions. Challenges posed by corneal defects, emphasizing the urgent need for advanced therapeutic interventions, are discussed. The review places a spotlight on exosome therapy as a potential therapy. CSSC-derived exosomes exhibit significant potential for modulating inflammation, promoting tissue repair, and addressing corneal transparency. Additionally, the rejuvenation potential of CSSCs through epigenetic reprogramming adds to the evolving regenerative landscape. The imperative for clinical trials and human studies to seamlessly integrate these strategies into practice is emphasized. This points towards a future where CSSC-based therapies, particularly leveraging exosomes, play a central role in diversifying ophthalmic regenerative medicine.
The Dual Role of Chemerin in Lung Diseases
Authors: Lavis Philomène , Bondue Benjamin , Cardozo Alessandra Kupper
Published: January 2024

Chemerin is an atypical chemokine first described as a chemoattractant agent for monocytes, natural killer cells, plasmacytoid and myeloid dendritic cells, through interaction with its main receptor, the G protein-coupled receptor chemokine-like receptor 1 (CMKLR1). Chemerin has been studied in various lung disease models, showing both pro- and anti-inflammatory properties. Given the incidence and burden of inflammatory lung diseases from diverse origins (infectious, autoimmune, age-related, etc.), chemerin has emerged as an interesting therapeutical target due to its immunomodulatory role. However, as highlighted by this review, further research efforts to elucidate the mechanisms governing chemerin’s dual pro- and anti-inflammatory characteristics are urgently needed. Moreover, although a growing body of evidence suggests chemerin as a potential biomarker for the diagnosis and/or prognosis of inflammatory lung diseases, this review underscores the necessity for standardizing both sampling types and measurement techniques before drawing definitive conclusions.
Effectiveness of a Novel Compound HAIR & SCALP COMPLEX on Hair Follicle Regeneration
Authors: Ferruggia Greta , Contino Martina , Zimbone Massimo , Brundo Maria Violetta
Published: January 2024

Background: People lose between 50 and 100 hairs a day and generate new ones from stem cells in hair follicles, but in those suffering from baldness, the stem cells remain inactive and are unable to regenerate new hair. Although 9% of hair follicles remain in telogen at any time, a variety of factors, including growth factors and cytokines, promote the transition from telogen to anagen and the subsequent stimulation of hair growth. Methods: We compared in vitro, on cultures of human hair follicles, the effect on hair growth and regeneration of the dermal papilla of plant-derived nanovesicles, exosomes from cord blood stem cells and bovine colostrum, a mixture of growth factors and cytokines purified from bovine colostrum, called GF20, and a new compound called HAIR & SCALP COMPLEX obtained by adding exosomes isolated from colostrum to GF20. Results: The analyses demonstrated a significant increase in the growth of the bulb and the regeneration of the dermal papilla in the samples treated with HAIR & SCALP COMPLEX compared to the other elements tested. Conclusions: In this research, we propose a possible new treatment that could help significantly slow down hair loss and encourage new hair growth: HAIR & SCALP COMPLEX.
Proteomic and Metabolomic Analyses of the Blood Samples of Highly Trained Athletes
Authors: Malsagova Kristina A. , Kopylov Arthur T. , Pustovoyt Vasiliy I. , Balakin Evgenii I. , Yurku Ksenia A. , Stepanov Alexander A. , Kulikova Liudmila I. , Rudnev Vladimir R. , Kaysheva Anna L.
Published: January 2024

High exercise loading causes intricate and ambiguous proteomic and metabolic changes. This study aims to describe the dataset on protein and metabolite contents in plasma samples collected from highly trained athletes across different sports disciplines. The proteomic and metabolomic analyses of the plasma samples of highly trained athletes engaged in sports disciplines of different intensities were carried out using HPLC-MS/MS. The results are reported as two datasets (proteomic data in a derived mgf-file and metabolomic data in processed format), each containing the findings obtained by analyzing 93 mass spectra. Variations in the protein and metabolite contents of the biological samples are observed, depending on the intensity of training load for different sports disciplines. Mass spectrometric proteomic and metabolomic studies can be used for classifying different athlete phenotypes according to the intensity of sports discipline and for the assessment of the efficiency of the recovery period.