bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategy “treat to target” for patients with psoriasis. Relevant issues to biological therapy persistence
Authors: Bakulev A. L.
Published: February 2022

The review discusses the possibility of result-oriented treatment therapeutic strategy (Т2Т) for patients with psoriasis implementation, as well as analysis of the key factors to ensure stability of long-term therapy with the use of genetically engineered biological drugs. It contains data on targeted influence of inhibitor IL17A secukinumab on key factors in the immunopathogenesis of psoriasis, its efficiency and safety in treating patients with moderately-severe to severe psoriasis in the course of therapy lasting up to 3 years. It is shown that long-term usage of secukinumab with 300 mg dose once a month subcutaneously allows to reduce the severity index values and the prevalence of psoriasis PASI 90% to vast number of patients with this dermatosis, which fully corresponds to the T2T strategy. The review discusses the possibility of therapeutic response usage in the form of achieving PASI 90 as a new global goal for effective therapy for patients with psoriasis to be attained in clinical practice. We present data on immunogenicity profile of secukinumab and beneficial impact on efficiency, as well as on safety of treatment with the usage of this genetically engineered biological medication.
Associative link of clinical manifestations of the secondary syphilis of skin and mucosa with histocompatibility antigens Class I
Authors: Koshkin S. V. , Chermnyh T. V. , Zajceva G. A. , Evseeva A. L. , Ryabova V. V.
Published: February 2022

Sixty patients with different clinical symptoms of secondary syphilis (ulcer chancres, pustular syphilis, hypertrophic papules, widespread leukoderma and alopecia) were examined in order to study the distribution pattern of histocompatibility antigens of the first class in patients with secondary syphilis of the skin and mucous membranes. As a result of the study, the presence of an associative relationship between the distribution pattern of histocompatibility antigens of the first class and various clinical manifestations in patients with secondary syphilis was established.
Can the lesions induced with actinic keratosis become an enigma for dermatologists? Results of an open perspective study
Authors: Bujnauskajte E. . , Rubins S. . , Rubins A. . , Makstiene Y. . , Bujnauskiene Y. .
Published: February 2022

Different face skin diseases (basal cell carcinoma, actinic keratosis, rosacea, solar elastosis, etc.) could clinically manifest itself as erythematic patches, pimples or plagues. It is very hard to make the clinical exclusion in some cases of these diseases since their characters can partially overlap or certain lesion can mimic another one especially in the cases of skin areas affected with sun. Therefore, the histopathological analysis remains the “golden standard” of the dermatological diagnosis at skin diseases. Our study has shown that certified dermatologists detect actinic keratosis (AK) of face/head skin of I/II levels very well. Verdicts of dermatologists and pathomorfologists are congruent on account of diagnosis in 90,7% cases. Diseases clinically excluded as AK revealed as malignant neoplasms (basal cell carcinoma) in less than 1% of case lesions.
AUTOIMMUNE BULLOUS DERMATOSES. DIFFERENTIAL DIAGNOSIS
Authors: Al'banova V. I. , Nefedova M. A.
Published: February 2022

The review presents modern ideas concerning autoimmune bullous dermatoses (pemphigoid group): Duhring disease, bullous pemphigoid, cicatrizing pemphigus, pemphigoid gestationis, linear IgA bullous dermatosis and acquired bullous epidermolysis. Pathogenesis, clinical manifestations and modern methods of disease diagnostics are reported. Particular attention is paid to the diagnosis of acquired bullous epidermolysis, in which the leading role belongs to the reaction of immunofluorescence. The pathogenetic similarity between bullous pemphigoid, linear IgA dermatosis, cicatrizing pemphigoid and pemphigoid gestationis is shown, which allows us to regard them as a variety of a single pathological process.
PRINCIPLES THERAPY OF ATOPIC DERMATITIS IN CHILDHOOD IN THE ASPECT OF MODERN CONCEPTS OF THE PATHOGENESIS OF THE DISEASE
Authors: Murashkin N. N. , Ambarchyan E.  T. , Materikin A. I.
Published: February 2022

The article contains data on the key links in the pathogenesis of atopic dermatitis in children. The authors of the article have covered modern approaches to topical therapy of atopic dermatitis in children. Modern algorithms of proactive therapy and control over the course of the disease are presented.
DIFFUSION NORMOLIPIDEMIC FLAT XANTHOMA, ASSOCIATED WITH HYPOCHROMIC ANEMIA. DESCRIPTION OF THE CASES
Authors: Elkin V. D. , Sedova T. G. , Plotnikova E. V. , Kuznetsov I. D. , Novoselova M. U.
Published: February 2022

The diffuse plane xanthoma (DPX) belongs to the class II of histiocytosis arising from the dermal dendritic cells (Histiocyte Society). The dominate role in the formation of the disease in the skin plays an accumulation of phagocytic immune complexes of macrophages. The clinical picture of the DPX is very specific and characterized by the appearance of periorbital xanthelasma and planar xanthomas on the skin of the trunk and extremities. The disease is often associated with hematological and lymphoproliferative diseases. The diagnosis is confirmed by histological examination.
Practical aspects of correction of local hyperhidrosis with the application of abotulinum toxin type A (Dysport®)
Authors: Yutskovskaya Y A , Tarasenkova M S
Published: February 2022

This article discusses practical aspects of treatment of local hyperhidrosis with botulinum toxin type A (Dysport®). This method
helps choose the individual dose of the administered drug taking into account the anatomical area and intensity of sweating, avoid
psycho-emotional disorders, obtain good clinical results, reduce the risk of the onset and recurrence of chronic dermatoses considerably
and improve the patients quality of life.
260 years of Alma Mater of Russian Syphilology
Authors: Zaslavsky D V
Published: February 2022

During Peter the Great syphilis and gonorea had such a wide spread, that so called spinning houses for easy virtues were established
in Saint Petersburg. One of this spinning yard established in 1718 by Peter the Great, later on was turned into the medical facility and
called Kalinkinskaya Hospital under the rein of Elizaveta Petrovna. Her decree dated August 1st, 1750 was the first official reference
of Kalinkinskaya Hospital as medical facility specialized in venerеological treatment. In this hospital the founder of Russian venereology
Benjamin Mikhailovitch Tarnowsky (1837-1906) lectured syphilolody for 25 years since 1859, initiated the establishment of
the Russian Venereological School, devoted his research to pereloy, gonorea, hypertrichosis, neurosyphilis, iodoform treatment.
Experimental syphilis, congenital syphilis, Ulcus vulvae acutum were studied within the hospital. In Soviet period Kalinkinskaya
Hospital was renamed to the Skin-Venereological Dispensary of the Leningrad Region. Nowedays it hosts the serological lab,
experimental syphilis lab and is considered the biggest mycological lab in Russia. The Dispensary houses 110 beds, 34 specially
equipped offices and 54 specialists.
Immunocorrection of urogenital inflammatory diseases associated with mycoplasms in women of childbearing potential
Authors: LETYAYEVA O I , GIZINGER O A , ZIGANSHINA T A , ZIGANSHIN O R , SEMYONOVA I V
Published: February 2022

The authors carried out a clinical, immunological and microbiological study in 176 women of childbearing potential suffering from mycoplasms in the lower urogenital tract. The revealed imbalance in the immunity of mucous tunics was successfully corrected with the use of Lavomax. The microbiota in the genital tract was normalized.
Particular features of treatment of keratodermas complicated with mycotic infection
Authors: LUKIYANOVA YE N , KORSUNSKAYA I M , NEVOZINSKAYA Z A , GALIYEVA N V , PIRUZYAN A L
Published: February 2022

The authors describe the results of complex treatment of keratodermas complicated with mycotic infection with the use of Travocort and drugs from the Dardia series.
Clinical and economic analysis of administering ustekinumab(stelara) to patients with severe psoriasis
Authors: Sura M V , Avksent'eva M V , Omel'yanovskiy V V , Kubanova A A , Sura M V , Avksentiyeva M V , Omeliyanovsky V V , Kubanova A A
Published: February 2022

There was a clinical and economic study of ustekinumab (stelara) as compared to etanercept (enbrel), infliximab
(remicade) and adalimumab (humira) for treating patients with severe psoriasis. The clinical efficacy and safety of the
biological drugs were analyzed, and estimated costs for their application as well as cost/efficacy ratio and cost efficacy
increment were calculated. Advantages of ustekinumab vs. etanercept were demonstrated: the costs per one patient
with severe psoriasis turned out to be less with the achieved positive effect. When the cost/efficacy ratio was calculated,
the economic advantages of ustekinumab vs. infliximab were established beginning with Weeks 24-28 of the therapy
(according to the results of individual studies, as early as beginning with Week 10 of the therapy). The economic
advantage of ustekinumab vs. adalimumab increases by Week 52 of the therapy. The calculations of the cost efficacy
increment proved that ustekinumab was more efficient than infliximab both in the short (Weeks 10-12 of the therapy)
and long run (Weeks 50-52) and more efficient than adalimumab in the long run (Week 52 of the therapy).
Using the Line Blot Syphilis test system for diagnosingsyphilis by the linear immunoblotting method
Authors: Mardanly C G , Arsen'eva V A , Frigo N V , Rotanov S V , Amelina E A , Zakharov M V , Mardanly S G , Arseniyeva V A , Frigo N V , Rotanov S V , Amelina Ye A , Zakharov M V
Published: February 2022

ZAO ECOlab (Russia) developed Line Blot Syphilis, a new test system on the basis of the linear immunoblotting method using Treponema рallidum recombinant antigens. The article assessed the diagnostic value of the Line Blot Syphilis test system in the form of a confirmatory test. As a part of the conducted study, the test system demonstrated its absolute sensitivity and specificity to serum-positive (n = 237) and serum-negative (n = 114) samples, in which the presence or absence of Т.pallidum antibodies was confirmed by two treponemal tests. As a result of examining 14 samples attributed to doubtful analytes based on two test results (passive hemagglutination test and immunofluorescence test with absorption), the data compliance between the Line Blot Syphilis test system and data from INNO-LIA Syphilis Score amounted to 100% (14/14) or 93% (13/14) for the immune-enzyme assay and 57% (8/14) for the immunofluorescence test with absorption. It is recommended to use the Line Blot Syphilis test system (ZAO ECOlab) as a confirmatory syphilis test.
A case of Bureau-Barrie`re-type sporadic ulcerative-mutilatingacropathy
Authors: Baltabaev M K , Mamytova E M , Zholdoshev E K , Baltabayev M K , Mamytova E M , Zholdoshev E K
Published: February 2022

A rare clinical case of Bureau-Barrie`re-type sporadic ulcerative-mutilating acropathy is described.
Using SIAscopy to assess the intensity of pathologic changes in skin when melanocyticneoplasms develop
Authors: Aksenenko M B , Ruksha T G , Tolstikhina N B , Kuznetsov S R , Aksenenko M B , Ruksha T G , Tolstikhina N B , Kuznetsov S R
Published: February 2022

The authors describe the use of spectrophotometry intracutaneous analysis method for the purposes of differential
diagnostics of pigmented skin neoplasms.
Experience of using ursodeoxycholic acid in complex treatment of patients suffering from atopicdermatitis
Authors: Baltabaev M K , Sadykova D A , Koybagarova A A , Baltabayev M K , Sadykova D A , Koibagarova A A
Published: February 2022

The authors describe the results of a clinical study of 90 patients suffering from different clinical forms of atopic
dermatitis (AD), who received hepatotropic drugs in combination with ursodeoxycholic acid. A misbalance of cellular and
humoral immunity was revealed in these patients prior to the onset of treatment. The inclusion of ursodeoxycholic acid in
complex treatment of AD contributed to normalization of immunity indices and regression of skin eruptions.
Advanced moisturizing products for the sensitive skin therapy
Authors: Pashinyan A G , Gordienko E S , Dzhavaeva D G , Shakhnovich A A , Pashinyan A G , Gordiyenko Ye S , Dzhavayeva D G , Shahnovich A A
Published: February 2022

The article presents the current data on the sensitive skin types and methods to study the skin biophysical properties.
The authors provide the data confirming the clinical efficacy of the Aqua Precis skin care products in patients with
sensitive skin.
Central centrifugal scarring alopecia as a rare form of scarring alopecia
Authors: Mareeva A N , Katunina O R , Egorova Yu Yu , Mareyeva A N , Katunina O R , Yegorova Yu Yu
Published: February 2022

The authors describe a rare form of scarring alopecia - central centrifugal scarring alopecia (synonym: follicular
degeneration syndrome). A particular feature of this disorder is a combination of scarring alopecia with pathology of the
thyroid gland. The authors also provide a classification of primary scarring alopecias.
Assessment of the efficacy of antihistamine drugs in complex treatment of chronic itchingdermatoses
Authors: Murashkin N N , Gluzmin M I , Materikin A I , Murashkin N N , Gluzmin M I , Materi kin A I
Published: February 2022

The authors give a review of current concepts of mechanisms of skin itching development for different types of chronic
dermatoses. The authors also present the results of a study aimed at assessing the efficacy of different 2nd generation
antihistamine drugs used for complex treatment of 83 patients aged 14-73 suffering from different chronic itching
dermatoses (atopic dermatitis, eczema, pruritus, chronic urticaria, progressing psoriasis, lichen acuminatus, contact
allergic dermatitis).
The authors conclude that Glencet (levocetirizine) used in a complex therapy of dermatoses accompanied with itching
can efficiently arrest both subjective itching sensations and objective clinical symptoms of the diseases as well as reliably
(р < 0.001) reduce the term of inpatient care by 4.8 ± 2.3 on average.
Glencet (levocetirizine) is a drug of choice among the 2nd generation antihistamine drugs used for treatment of chronic
skin diseases accompanied with itching.
Efficiency of information technologies in the process of rendering specialized dermatovenerologicalaid to the population of the Russian Federation
Authors: Martynov A A , Pirogova E V , MARTYNOV A A , PIROGOVA YE V
Published: February 2022

The authors present the results of a detailed analysis of information and telecommunications resources of regional
dermatovenerological institutions, describe major principles for establishing a common information system in the health
care system of the Russian Federation, and substantiate organizational and medical efficiency of introduction of an
information analytical system for monitoring the incidence of sexually transmitted diseases.
Lavomax - new potential of the complex therapy of genital herpes
Authors: Udzhukhu V Yu , Kubylinskiy A A , Udzhukhu V Yu , Kubylinsky A A
Published: February 2022

The goal of this study was to assess clinical efficacy and safety of Lavomax and to provide pathogenetic grounds for its
use in the complex therapy of patients suffering from genital herpes. The study subjects were 64 patients suffering from
genital herpes.
Their diagnosis was verified on the basis of ELISA and PCR results. Immunoassays revealed various disorders of immune
homeostasis and natural resistance. These results confirm that there are pathogenetic grounds to use Lavomax in the
complex therapy of genital herpes. Complex treatment with the use of Lavomax normalizes immune homeostasis and
quickly reduces clinical manifestations of herpes significantly reducing the frequency and duration of recurrences of the
disease.
Principles of a combination therapy of acne
Authors: Butareva M M , Znamenskaya L F , Kappusheva I A , Spiridonova E V , Egorova Yu Yu , BUTAREVA M M , ZNAMENSKAYA L F , KAPPUSHEVA I A , SPIRIDONOVA YE V , YEGOROVA YU YU
Published: February 2022

The authors discuss problems of selection of an adequate therapy for treatment of patients suffering from acne taking into account the clinical picture, course of the pathological process, efficiency of previous treatment, presence or absence of endocrinopathies.
Analysis of the results of clinical and laboratory examination of female patients withnon-complicated and complicated forms of the urogenital chlamydia infection
Authors: Plakhova K I , Rakhmatulina M R , Frigo N V , Rotanov S V , Volkov I A , Khayrullin R F , PLAKHOVA K I , RAKHMATULLINA M R , FRIGO N V , ROTANOV S V , VOLKOV I A , KHAIRULIN R F
Published: February 2022

полиморфизмы, хламидийная инфекция, цитокины.
The authors provide a detailed clinical and laboratory description of female patients with the Chlamydia infection of the
lower urogenital tract and small pelvis organs as well as patients with secondary infertility (Chlamydia infection in the
anamnesis). The authors also present the results of a pilot study aimed at determining the content of cellular metabolism
mediators (cytokines IL-2, IL-4, IL-6, IL-8, IL-10 and IFN-alpha) in blood and cervical secret samples as well as a study of
single-nucleotide polymorphisms of cytokine encoding genes.
Algorithm for external treatment of dermatoses of mixed etiology
Authors: Belousova T A , Goryachkina M V , BELOUSOVA T A , GORYACHKINA M V
Published: February 2022

There has been an increase in the number of dermatology patients suffering from several concomitant skin diseases
of different etiology for the past decade. A special term - dermatoses of mixed etiology (DME) - was suggested to
describe this group of diseases. According to the authors, long-term uninterrupted treatment with one-component topical
drugs or unreasonable administration of three-component combination agents is the most frequent reason for DME.
The authors describe their positive experience of administering Travocort as a part of DME treatment. The effect of the
drug was observed as early as on the second day of its administration: there was an active regression of hyperemia,
edemas and skin oozing lesions in the foci. Itching and stinging disappeared almost completely, which also alleviated
the patients condition. On Days 3-4, no formation of new vesicles was observed, there were no oozing lesions, and
erosion cuticularization began on an active basis. Therefore, Travocort is a highly efficient drug for treatment of infectious
dermatoses complicated with eczematization as well as chronic inflammatory diseases exacerbated by a concomitant
fungous and bacterial infection.
Research methods for molecular markers of the individual genetic risk for development ofcomplications of the urogenital chlamydia infection
Authors: Plakhova K I , Volkov I A , Khayrullin R F , Rotanov S V , Popov D V , Rakhmatulina M R , Frigo N V , PLAKHOVA K I , VOLKOV I A , KHAIRULIN R F , ROTANOV S V , POPOV D V , RAKHMATULLINA M R , FRIGO N V
Published: February 2022

The authors present the results of the first four stages of research conducted under Government Contract No.
02.740.11.0774: Development of a Technology for Molecular Diagnostics of the Individual Genetic Risk of Development of
Reproductive Function Disorders Associated with Human Urogenital Chlamydial Infection.
Necrolytic erythema: oddities
Authors: Tlish M M , Gluzmin M I , Kuznetsova T G , TLISH M M , GLUZMIN M I , KUZNETSOVA T G
Published: February 2022

Powered by monitoring a patient with clinical manifestations of erythema associated with nekroliticheskoyglyukagonomoy.
The attention to the diagnostic criteria of the disease. Formation of cutaneous syndrome glyukagonomelets talk about its
nosological specificity.
Basalioma: epidemiology, etiology, pathogenesis and clinical picture (part 1)
Authors: Volgin V N , Sokolova T V , Kolbina M S , Sokolovskaya A A
Published: February 2022

The authors present literature data related to the epidemiology, etiology, pathogenesis and clinical course of basalioma. The key classifications are given. As many as 62 references are reviewed.
Basalioma: diagnostics, treatment (part 2)
Authors: Volgin V N , Sokolova T V , Kolbina M S , Sokolovskaya A A
Published: February 2022

The author present data related to the diagnostics and therapy of basalioma. As many as 62 references are reviewed.
Etiology of foot mycosis and onychomycosis
Authors: Kozhichkina N V
Published: February 2022

The article presents data from Russian and foreign sources related to the etiology of foot mycosis and onychomycosis. In spite of the substantial spread of data by countries and regions of the world, dermatophytes play a leading part in the etiology of foot mycosis and onychomycosis, and Trichophyton rubrum is found in most studies in more than one half of all cases. Yeast-like fungi of the Candida genus as well as mold fungi belong to less frequent pathogens of foot mycosis. However, they play a greater role in countries with hot and humid climate such as Brazil, Indonesia, Columbia and India. These data are important for the determination of organizational measures aimed at the early diagnostics of patients, timely treatment and implementation of anti-epidemic and disinfectant measures.
Methods for the determination of M class anti-T. pallidum antibodies for early diagnostics of syphilis
Authors: Rotanov S V , Chuprov-Netochin R N , Ermatova F A
Published: February 2022

The review covers issues related to the present-day administration of laboratory blood test methods for the determination of specific Class M immunoglobulins against antigens of the syphilis pathogen, T. pallidum (immune-enzyme assay, immunofluorescence reaction, linear immunoblotting). Indications and diagnostic features of the aforesaid medical methods for early diagnostics of acquired or congenital syphilis were determined; cases of reinfection were verified and the intensity of the infection was assessed in the patients who had previously received specific treatment. The article provides recommendations for using specific IgM determination methods described in present-day Russian and foreign guides and standards of syphilis diagnostics.
Distinctive features of steroid hormone metabolism in female patients with androgenic alopecia
Authors: Mareyeva A N , Rotanov S V , Chernukha G Ye
Published: February 2022

Goal of the study. To study the role of metabolic disorders related to steroid hormones for the genesis of androgenic alopecia in women. Materials and methods. The authors disclose the results of a study of blood serum and saliva concentrations of steroid hormones in 87 female patients suffering from androgenic alopecia and 30 healthy women. Results. A regular menstrual cycle in most of the patients with androgenic alopecia (87.8%) and low (10.3%) rate of the polycystic ovary syndrome confirm the low prevalence of clinical manifestations related to endocrine disorders in female patients with alopecia. An increased level of dihydrotestosterone was revealed in 44.8% of the female patients with androgenic alopecia while total and free blood serum testosterone levels were increased only in 11.5% and 12.6% of the patients, respectively. These data may serve as an indirect indication at the increased activity of 5-alpha-reductase promoting conversion of testosterone into dihydrotestosterone. The authors confirmed the information value of the free testosterone saliva level for assessing the hormonal background in the patients under examination. Conclusion. Based on the study results, it is recommended to determine the concentration of dihydrotestosterone, free androgen index and free testosterone saliva level as a part of examinations of women suffering from androgynous alopecia to evaluate their hormonal background.
Studying of the expression of PERP protein in the skin of patients with pemphigus
Authors: KUBANOV A A , KATUNINA O R , MICHENKO A V , ABRAMOVA T V
Published: February 2022

The authors disclosed the participation of apoptosis proteins in the development of acantholysis in patients with pemphigus. In this connection, studies of the PERP protein passing apoptosis signals and regulating desmosomal functions in keratinocytes are of interest. There is no information about any studies aimed at the PERP protein expression in patients with pemphigus in available literature. Goal. To assess the PERP protein expression in the skin of patients with pemphigus. Materials and methods. There was a study of 22 patients with pemphigus, a patient with bullous pemphigoid and ten healthy people. The PERP protein expression was studied in the biopsy materials obtained from lesion foci and apparently healthy skin of the patients as well as healthy people using the indirect immunofluorescence method. Results. The PERP protein expression was revealed in patients with pemphigus on areas of apparently intact skin, in lesion foci in the patient with bullous pemphigoid and skin of healthy volunteers in the membrane of keratinocytes from all epidermal layers.The PERP protein expression in the blister operculum in lesion foci in patients with pemphigus was absent. Conclusion. Substantial differences in the PERP protein expression in the blister operculum and apparently intact skin of patients with pemphigus were revealed.
Molecular monitoring and determination of N. gonorrhoeae sensitivity to antimicrobial drugs as tools to control the propagation of gonococcal infection in the Arkhangelsk Region
Authors: Baryshkov K V , Frigo N V , Solomka V S
Published: February 2022

As a result of studying the sensitivity indices concerning antimicrobial drugs (AMD) for 203 strains of N. gonorrhoeae obtained from patients suffering from the gonococcal infection in the Arkhangelsk region, it was established that the trends of N. gonorrhoeae strains propagation, which are resistant to AMD, match the trends in Russia in general. Ceftriaxone is the drug of choice to treat the gonococcal infection in the territory of the region. It was observed that N. gonorrhoeae strains started developing resistance to the AMD in the territory of the region. The authors conducted a study of 51 N. Gonorrhoeae strains obtained from patients suffering from the gonococcal infection in 2011 using molecular epidemiology methods (sequence and phylogenetic analysis). Heterogeneity in the sample of the N. gonorrhoeae strains circulating in the territory of the Arkhangelsk region as well as high rate of their genetic variability were revealed. It was noted that N. gonorrhoeae strains, which are unique for this geographic region (dominating sequence types No. 343, 5042, 1523, 1152, 387, 6238, 5825 and 6234 as well as single sequence types), are registered in the territory of the Arkhangelsk region. The authors demonstrated the possibility to use molecular methods (PCR and sequence analysis) for individual identification of infection sources and sexual partners of patients suffering from the gonococcal infection and for the purposes of epidemiological monitoring. The authors established associations between the fact that the N. gonorrhoeae strains obtained from patients suffering from the gonococcal infection in the Arkhangelsk region belong to sequence types No. 343, 285, 2625 and 6237, and their multi-resistance, which demands a thorough examination to determine the treatment tactics for such patients. Taking into consideration the results of these studies, the authors prepared recommendations on how to control the propagation of the gonococcal infection in the territory of the Arkhangelsk region.
Practical aspects of the management of patients with chronic hand eczema
Authors: PERLAMUTROV YU N , OLKHOVSKAYA K B
Published: February 2022

Urgency. High prevalence ot hand eczema stipulates the urgency ot studies ot significant factors ot the torpid course ot this disease, which is a result ot the sensitizing power ot the pathogenic biota in most cases. Goal. Optimization ot the therapy ot true hand eczema associated with chronic paronychias. Materials and methods. The tollow-up study comprised 30 patients suttering trom true hand eczema associated with chronic paronychias who underwent clinical and laboratory examinations with the determination ot the severity ot eczema, skin contamination and level ot specitic anti-Candida antibodies. Results. The authors revealed an evident clinical and laboratory etticacy ot the monotherapy with the Triderm cream aimed at the elimination ot paronychias and hand eczema.
Systemic therapy of acne in teenagers
Authors: Sergeyeva I G , Krinitsyna Yu M , Makarova N G , Dyagileva A A
Published: February 2022

The goal was to determine clinical and anamnestic features of acne patients aged up to 18 years needing systemic isotretinoin treatment, and to assess the treatment dynamics. Materials and methods. The authors conducted a study of 27 patients with moderate to severe acne (with the mean age of 16.2 ± 1.2 years) receiving isotretinoin in the form of LIDOSE (Acnecutan) in the dose of 0.33 ± 0.06 mg/kg. Results. A steady improvement of the skin condition was observed when the dose of isotretinoin in the form of LIDOSE of 60.3 ± 2.8 mg/kg was used. Clinical recovery was observed in all of the patients (the cumulative dose amounted to 100 mg/kg). Teenagers demonstrated good tolerance to the drug and had no systemic adverse effects.
Practical aspects of administering Acnecutan for the treatment of acne in teenagers
Authors: Tlish M M , Yelistratova A S , Gluzmin M I
Published: February 2022

Goal of the study: to study the efficacy and tolerance of Acnecutan for the treatment of acne in teenager patients. Materials and methods. The study involved 43 patients aged 12-18 with moderate to severe acne, who received Acnecutan* as a monotherapy. The skin process dynamics was assessed visually based on the Basic Acne Severity Index (BASI). Results. Clinical recovery was achieved in 39 patients (90.7% of all cases), and clinical improvement was observed in 4 patients (9.3%). Conclusion. The results of Acnecutan administration demonstrate a high level of its efficacy and tolerance in teenagers. To assess the stability of the results achieved and to draw final conclusions, the patients will be followed up within a year after the end of the therapy. Therefore, the drug can be recommended as a monotherapy for acne of different clinical forms in teenager patients.
Informatization of medical institutions of the dermatovenerology profile. Current requirements for statistical accounting
Authors: KUBANOV A A , KASPIROVICH M A , MELEKHINA L YE , BUTAREVA M M , RUBTSOV A B
Published: February 2022

The authors present materials reflecting tendencies in the development of informatization at different levels of the health care system; results of the introduction of the Medical Information System of the State Research Center for Dermatology, Venereology and Cosmetology in the operations of medical institutions of the dermatovenerology profile in subjects of the Russian Federation; draft accounting forms prepared in compliance with the current requirements for statistical accounting for medical institutions of the dermatovenerology profile for the purpose of further development of information systems.
Major directions and changes in the course of the reorganization of the medical aid system for the population in the Russian Federation
Authors: BUTAREVA M M
Published: February 2022

The article discusses issues of the reorganization of the health care system in the field of medical aid rendered to the population, which occurred in the Russian Federation during the period from 2005 to 2010.
Role of gonococcal infection and its forms associated with other sexually transmitted infections in the development of clinical and morphological changes in the cervix
Authors: SHERMAN J F , SHEVLUK N G , VORONINA L N , MIKHAILOVA E A , SHTIL O O
Published: February 2022

Studied the clinical and morphological features of the mucous membrane of the cervix during gonococcal infection and its association with other sexually transmitted mainly through sexual contact. Established clinical features of inflammatory changes in cervical mucus and the peculiarities of its structure and state of repair processes in it for women with gonococcal and in association with her chlamydia and trichomoniasis infections. Revealed that the destructive changes in cervical mucus, and decreased reparative features a single-layered columnar epithelium are most pronounced in women with combined forms of gonococcal infections: gonococcal-chlamydial and gonococcal-trichomoniasis.
Efficiency and relevance of the use of an oxygen-ozone mixture in the complex treatment of acne in men
Authors: PAVLENKO T YA , SIDORENKO O A , SIZYAKINA L P
Published: February 2022

The purpose of the study was to substantiate the relevance of the use of an oxygen-ozone mixture in the complex treatment of acne in men. Materials and methods: The study involved 46 male patients aged 15 to 27 suffering from acne vulgaris of moderate severity. patients from the control group received a standard therapy (systemic antibacterial drugs, benzoyl peroxide and adapalene as external drugs), and patients from the main group received an oxygen-ozone mixture in addition to standard drugs. Clinical evaluation of the intensity of the process was carried out prior to and after the treatment (using the Cook scale), and severity of scarring was assessed by the Vancouver scale; immune status parameters were also assessed. Results: positive clinical dynamics was observed in both groups. normalization of immune status parameters was additionally observed in patients from the main group. Conclusion: the study demonstrated the efficiency of a combined therapy including the introduction of an oxygen-ozone mixture in addition to traditional drugs, so this regimen of treatment can be recommended as a therapy for acne of moderate severity.
Assessment of the clinical significance of the chemiluminescence immuncassay in the diagnostics of the syphilitic infection
Authors: ROTANOV S V , FRIGO N V , MANUKIAN T YE , PODGURSKY G M
Published: February 2022

The authors present the results of an assessment of the clinical efficacy of the use of the chemiluminescence immunоassay (CLIA) for determination of anti- T. pallidum antibodies in the diagnostics of the syphilitic infection with the use of IMMULITE® 2000 Syphilis Screen, a reagent kit developed on the basis of Tp17 recombinant antigen. The use of 306 samples of blood serum collected from patients suffering from different clinical forms of the syphilitic infection, 61 samples collected from active blood donors and 20 samples collected from persons with biologically false-positive immunochemical (serological) reactions for syphilis demonstrated a high clinical sensitivity (99.68%), specificity (96.30%) and reproducibility (100%) of the chemiluminescence immunоassay results. The high clinical efficacy of the study results combined with the speed of its performance and full automation of the laboratory study process are sufficient to recommend including the chemiluminescence immunоassay in regulated methods for primary examination (screening) of the population for the syphilitic infection along with treponemal tests such as immunoenzyme assay (IEA) and passive hemagglutination reaction.
А case of erythrokeratodermia variabilis (Mendes da Costa type) in a three-year-old child
Authors: PROSHUTINSKAYA D V , TEKUCHEVA L V , TROFIMCHUK I A , KATUNINA O R , BALABEKOVA F G
Published: February 2022

The authors describe a case of erythrokeratodermia variabilis (Mendes da Costa type) in a three-year-old child. They present data on the clinical picture and histological examination. Major stages of the etiology and pathogenesis of the diseases are described.
Classics and innovations in the external therapy of chronic dermatoses
Authors: TAMRAZOVA O B
Published: February 2022

The article presents data from the literature on the efficiency and safety of using different topical drugs for the treatment of dermatoses, and describes methods for the efficient multistage treatment of chronic allergic dermatoses using keratoplastic agents comprising ASD (Antiseptic Dorogov’s Stimulator) (the 3rd fraction) as the active substance.
Role of MRSA strains in the pathogenesis of severe atopic dermatitis in childhood. The ways of remission achievement
Authors: MURASHKIN N N , GLUZMIN M I , SKOBLIKOW N E , BAKULEV A L , MATERIKIN A I , GLUZMINA M M , KHOTKO A A
Published: February 2022

This article presents results of examination of 63 patients with atopic dermatitis (AD) aged 3 to 18 years. It was demonstrated, that in 87.3% of cases their skin was contaminated by Staphylococcus aureus. In 58.2% of cases pathogenic strains of methicillin-resistant Staphylococcus aureus (MRSA) were detected. Direct correlation between the frequency of MRSA detection and severity of the disease (r = 0,68) as well as age of children (r = 0,58) was revealed. Authors revealed high frequency of multidrug-resistant strains to a variety of antibiotics, except mupirocin, vancomycin, clindamycin, and ciprofloxacin (in the total group of MRSA the prevalence of resistant strains to these antibiotics ranged from 2% in mupirocin to 18% in ciprofloxacin, depending on the severity of AD). Algorithm of the effective combined therapy with mupirocin containing topical drugs (Supirocin ointment, Supirocin B ointment) is presented. This algorithm allowed to achieve stable clinical remission in 100% of cases.
First clinical experience of the use of ustekinumab (Stelara) for treatment of psoriatic patients in Russia
Authors: Znamenskaya L F , Svishchenko S I
Published: February 2022

The authors examined the efficacy and safety of treatment of patients suffering from moderate to severe forms of psoriasis with ustekinumab (blocker of р40 subunit of interleukin-12 and interleukin-23) taking into account the PASi index. They revealed high clinical efficacy of ustekinumab for treatment of psoriatic patients.
Role of modern topical steroids in treatment of atopic dermatitis in children
Authors: Orlov E V , Konnov P YE , Chaplygina S I
Published: February 2022

Atopic dermatitis is a widespread problem, and its treatment is a complicated problem for clinicians. The efficacy, safety, cost and complexity of therapeutic measures are the Key components for treatment compliance and ultimately define the success of treatment. The article presents the results of a prospective open-label study of the clinical efficacy of the application of mometasone furoate (Elocom) for atopic dermatitis in children with the exudative and erythematous squamous forms with initial signs of lichenification and its effect on the IDLQI (Infant's Dermatological Life Quality Index). It was established that the application of Elocom vs. the hydrocortisone cream and ointment (in case of the exudative form) contributed to the faster reduction of the intensity of clinical manifestations of atopic dermatitis.
Efficiency of the therapy of onychomycosis with irunine (based on the results of a multicenter study conducted in 2010 and 2011)
Authors: Faizullina Ye V , Silina L V , Faizullin V A
Published: February 2022

The article presents the results of a multi-center study of the clinical efficiency of the use of Irunine ® (itraconazole) for the treatment of 1,340 patients with onychomycosis. Patients were administered two capsules (100 mg) of Irunine ® twice a day after a meal for 7 days (as a pulse therapy) with a three-week break. The duration of treatment was 3—5 months. Clinical recovery was achieved in 74.9% of cases, and stable improvement was observed in 23.4% of patients.
Principles of skin care for patients with rosacea
Authors: Pashinyan A G , Shapoval E S , Dzhavayeva D G , Arutyunyan G B
Published: February 2022

The article covers problems of vegetovascular changes in case of rosacea. The efficacy and safety of skin care products for rosacea patients were evaluated.
Study of the genetic factors predisposing to the development of psoriasis
Authors: LVOV A N , KATUNINA O R , ZNAMENSKAYA L F , MICHENKO A V , EGOROVA Y Y , INOYATOVA L A , HAIRULLIN R F , VOLKOV I A
Published: February 2022

Many findings confirm the influence of neuropsychic factors on the manifestation and exacerbation of the atopic dermatitis and psoriasis. Nowadays it is assumed that by means of neurotransmitters’ secretion the nervous system can influence different processes, including the immune mediated inflammation, which has the key role in the pathogenesis of such dermatosis. The article hereunder contains comprehensive data on prospective trends of following studies of the nervous regulation participation in the pathogenesis of such dermatosis.
First experience of health school work for patients, suffering from health transmitted diseases clinical cases
Authors: DUMCHENKO V V , SADIROVA E K
Published: February 2022

Presents first results of work of health school for patients, suffering from sexually transmitted diseases. The significance of the training prophylactic program, addressed to patients with sexually transmitted diseases.
Harlequin ichtyosis (harlequin fetus): case description
Authors: BELIKOV A N , ALBANOVA V I , KOMLEVA L F , GOLCHENKO V A
Published: February 2022

Harlequin ichtyosis was observed at a girl, who managed to survive till 4 months age. Results of postmortem examination were presented. Diagnostic criteria were described, issues of prenatal diagnostics and treatment opportunities are being discussed.
Combined pharmaceuticals in the external treatment of acne: modern data
Authors: ARAVYISKAYA E R , SOKOLOVSKY E V
Published: February 2022

This paper presents the results of the performed clinical study to determine the effectiveness of use of therapeutic cosmetics of AYSIDA line in complex therapy of acne.
Proactive external therapy of children and adults, suffering from atopic dermatitis - new effective tactic approach
Authors: KUNGUROV N V , KOHAN M M , KENIKSFIRST Y V , ZASADKEVICH Y M
Published: February 2022

Target. To evaluate the efficiency of the external therapy of atopic dermatitis with 0,03% tacrolimus ointment and 0,1% tacrolimus ointment of children and adults accordingly. Маterial and methods. Were submitted results of the long-term clinical supervision of 38 patients, suffering from atopic dermatitis, receiving the external therapy with 0,03% tacrolimus ointment (children) and 0,1% tacrolimus ointment (adults) twice a day during the first (active) stage of treatment in the support therapy mode 2 times a week, carried out up to 3 months. Results. The high therapeutic efficiency was established with clinical remission and considerable improvement at 88,8% of children and 75,0% of adults with atopic dermatitis, patients’ life quality recovering, maintenance of achieved treatment results during 3 months of supporting therapy. Opinions. Obtained results witness the expedience of the use of tacrolimus ointment in the proactive therapeutic mode.
On the efficiency and safety of application of the short course of clobetasol propionate at patients, suffering from psoriasis in the progression phase
Authors: BAKULEV A L , KRAVHCHENYA S S
Published: February 2022

Research target: to evaluate the efficiency and safety of the application of clobetasol propionate ointment (Cloveit ointment for external application, Jelfa) at 60 patients, suffering from plaque psoriasis of average gravity in dermatosis progression phase. Material and methods. The panel comprises 60 patients, suffering from psoriasis (36 men and 24 women) in the age of 25-55 y.o. (the average age is 35,4 ± 2,1 years). The disease continuity was between 6 months and 12 years. The therapeutic efficiency was evaluated with PASI, PGA indices, аs well as with data of ultrasonographic research. Results. Initiating seven days course of the topical therapy with clobetasol propionate, included in the standard comprehensive treatment, favors the transfer of the psoriatic process in the stabilization phase and is not accompanied with clinical and sub-clinical features of skin atrophy.
Efficiency and tolerability of 0,1% tacrolimus ointment in the treatment of patients with moderate atopic dermatitis. Effect of the medication on the skin microcirculation
Authors: SOKOLOVSKY E V , MONAHOV K N , AKSENOVA O I
Published: February 2022

The article covers modern concepts of the influence of calcineurin inhibitors on formation and liberation inflammatory cytokines and their immunomodulating ability. Goal: to estimate efficiency and bearableness of 0,1 % Tacrolimus ointment (Protopik) at treatment of atopic dermatitis of moderate severity and eczema of hands as supporting therapy, and also influence of a preparation on microcirculation in skin. Materials and methods. In research took part 35 patients having atopic dermatitis (ATD) of moderate severity. The preparation Protopik (0,1% ointment) was used externally by daily thin layer on well cleared skin 2 times a day before clinical improvement, but not less than 2 weeks. Further, at achievement of clinical remission, it was recommended to use a preparation 2 times a week on the sites of skin which are usually struck at aggravations. In other days it was recommended to patients to use a relipidant. To patients with atopic dermatitis before the beginning of treatment and in 1 month from the beginning of application of a preparation by means of Doppler monitoring research microcirculation level in skin (volume speed of a blood-groove) was estimated. Results. High activity of a preparation as means of long supporting therapy is shown. Continuous application of a preparation within 2 weeks allows to reach in most cases almost complete remission. According to Doppler monitoring research, microcirculation in skin at patients with ATD after external application of 0,1% Tacrolimus ointment (Protopik) amplified that it is possible to explain decrease in an infiltration in a dermis. Use of a preparation differs sufficient comfort, and individual complaints to local irritation in the area where the ointment was applied were transient by nature.
Experience of the combined therapy of anogenital (veneral) warts
Authors: RAHMATULINA M R
Published: February 2022

The article covers issues of ethiology and pathogenesis of papilloma viral infection, modern perceptions of the role of immune mechanisms in the development of the infection process. Were submitted results of the comparative clinical research for the study of efficiency and safety of Ingaron substance (γ-interferon) in the comprehensive therapy of the anogenital papilloma viral infection.
Current clinical and epidemiological features of neurosyphilis
Authors: GORODNICHEV P V , KLEMENOVA I A , BELOVA A N , MISHANOV V R
Published: February 2022

The authors present the results of the analysis of the dynamics of the neurosyphilis incidence rate based on the state statistical reporting data in the Volga Federal District in 2003—2011. According to the authors, there is a growth in new neurosyphilis cases against the background of the reduced incidence rate of syphilis. The authors also revealed that late forms of neurosyphilis dominate in the neurosyphilis incidence structure. They conducted an analysis of anamnestic and clinical data of patients who were diagnosed with neurosyphilis, and discovered and a number of particular features in the current clinical picture of the disease. According to the authors, basal meningitis mainly affecting the optic, oculomotor and eighth cranial nerve is diagnosed most often in case of early-onset neurosyphilis. Latent and often mono-symptom forms with prevalent intellectual, memory and emotional-volitional disorders are characteristic of late neurosyphilis.