bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF MALIGNANCY UNDERESTIMATION IN BREAST PAPILLARY LESIONS DIAGNOSED AT PERCUTANEOUS BIOPSY IN A SOUTH BRAZILIAN ANATOMOPATHOLOGICAL LABORATORY CENTER
Authors: Lapa Flávia da Rocha , Coelho Karina Munhoz de Paula Alves , Tavares Lara Cristina de Carvalho , Brusamarello Aneline
Published: April 2023

Objective: The aim of this study was to discover the percentage of patients who underwent surgery due to a biopsy with a diagnosis of papillary lesion and who had their diagnosis underestimated for cancer, analyzing the biopsy data and comparing it with the post-surgical results in the past 10 years. Methods: Anatomopathological examinations of percutaneous core-type or vacuum breast biopsy between 2010 and 2020 with a result of the papillary lesion were analyzed and compared with the anatomopathological result obtained surgically. Cases in which the biopsy already demonstrated malignancy were excluded. The data were from the CEDAP (Centro de Diagnósticos Anátomo-Patológicos) pathological anatomy laboratory database in Joinville, Santa Catarina. Results: In the reported period, 126 biopsies were recorded with a diagnosis of breast papillary lesion. Of these, 21 were excluded because they did not meet the established criteria. In the follow-up examinations of the papillary lesions after surgery, 76 (72.4%) corresponded to benign lesions, including 30 cases demonstrating atypia, and 29 (27.6%) to carcinomas, of which 14 corresponded to invasive lesions and 15 in situ carcinomas. Conclusion: Papillary breast lesions are a diagnostic challenge in a biopsy, requiring sequential surgical excision, even though this practice is being questioned nowadays, due to the high risk of underestimation.
ANALYSIS OF TUMOR RESPONSE IN THE BREAST AND AXILLA ACCORDING TO MOLECULAR SUBTYPE IN BREAST CANCER PATIENTS SUBMITTED TO NEOADJUVANT CHEMOTHERAPY
Authors: Sá Nayara Carvalho de , Lucena Clécio Ênio , Brandão Flávio Silva , Pires Douglas de Miranda , Couto Henrique Lima , Lewer Marcelo Henrique Mamede , Ferreira Roberta Nogueira Furtado
Published: April 2023

Objective: Pathological complete response rate (pCR), ypT0/is ypN0, after neoadjuvant chemotherapy (NAC) varies in each molecular subtype of breast cancer, being lower in hormone receptor-positive (HR+) tumors. The objective of this study is to analyze the pathological response rate (PR) only in the breast, only in the axilla or the pCR, correlating with the molecular subtypes. Methods: This is a retrospective observational study of stage II and III patients undergoing NAC between 2013 and 2020 at the Oncology and Mastology Service of Santa Casa de Misericórdia de Belo Horizonte – MG (SCMBH). This study was approved by the Research Ethics Committee of SCMBH with the number 3,787,212 complying with Resolution 196/96 of the National Council for Ethics in Research. Results: In all, 209 patients were selected with a mean age of 50.6 years; 22.0% were T2, 35.9% were T3, and 42.1% were T4; 17.2% were pre-NAC cN0 and 82.7% were cN+. Patients were divided into group A, RH+, with 147 patients (70.3%), and group B, HER2+ and TN, with 62 patients (29.7%). When comparing PR only in the breast, RH+ patients had a better result (4.8% versus 1.6%); as well as PR only in the axilla, 37.4% against 29.0%. When subdividing group A into RH+/HER2− and RH+/HER2+, the former presented better results in the breast (4.3% X 0%) and in the axilla (60.9% X 55.6%). Conclusion: Achieving pCR is not the only goal of NAC. Other benefits include the possibility of breast and axilla-conserving surgery. The study demonstrated good PR results in both the breast and the axilla in group A and in the RH+/HER2− subgroup. These responses allow for a less morbid surgical treatment, both aesthetically and because of the risk of lymphedema. The data presented provide a compelling rationale for the use of NAC in a molecular subtype considered to be relatively resistant to chemotherapy.
The Effect of Ball-Powder Ratio on The Mechanical and Structural Properties of CuZrB Composite Materials Fabricated by Powder Metallurgy
Authors: Simić Marko , Ružić Jovana , Božić Dušan , Stašić Jelena
Published: April 2023

Copper matrix composites exhibit excellent mechanical and thermal properties. The composite consists of copper (Cu), zirconium (Zr), and boron (B) and is produced using the powder metallurgy technique. The high-energy ball milling was applied for mechanical alloying of the Cu-Zr-B powder mixture to achieve the desired ratio for obtaining a copper matrix reinforced with ZrB2 ceramic particles. The milling times of 10 and 40 hours for two different ball-to-powder ratios are investigated for a powder mixture with a composition of Cu-2.71Zr-2.27B (wt.%). XRD and SEM analyses were employed to determine structural and morphological changes in the mechanically alloyed powder mixture. Investigation of the morphological parameters shows that with prolonged milling, the shape of mixed particles becomes more uniform, while their structural parameters have been drastically changed. It is determined that during high-energy ball milling of the Cu-2.71Zr-2.27B (wt.%), the size of the copper powder decreases as the mechanical alloying increases for both ball-powder ratios. Dislocation densities reach their maximum value at around 30 hours of mechanical alloying for both ball-powder ratios, with dislocation density being higher for the 1:15 ratio, after which they decrease owing to the recrystallization of the copper matrix. XRD analysis shows no presence of ZrB2 reinforcement particles or oxides during milling.
Anteropituitary insufficiency secondary to head trauma: A case report
Authors: W Douali  , L. Abaïnou  , C. El aalami  , F. El jaafari  , S El Hadri  , H. Baïzri  , A Meftah
Published: April 2023

Head injury (HIT) is a public health problem, post-traumatic pituitary deficits are a rare complication, the etiopathogenic mechanisms of pituitary insufficiency in HIT are variable, the most frequent deficiency in HIT is that of GH and gonadotropins, hypothalamic-pituitary MRI is the key paraclinical examination; and management is multidisciplinary.
Method for the growth of Herpes Simplex Virus (HSV-1 and HSV-2) in an oxygen-free environment
Authors: Balbina J. Plotkin  , Ira M. Sigar, Amber Kaminski  , Alexis Borrelli  , Victoria Zheng  , Nicholas Schileru  , Michelle Aelion  , Brandon Siaj
Published: April 2023

Vaginal herpes infections occur under low oxygen conditions, including anoxia. Using an anaerobic (0% O2) cell system, the infection rate, early protein expression, and progeny viability were determined. Anaerobic HeLa 229 cells (0% O2; anaerobic DMEM; 24h) were infected with MOI 1 of HSV1/2, then incubated under aerobic (control) and anaerobic conditions. Infectivity (6h post-infection (pi)) was assessed by ONPG activity and enumerating X-gal-stained cells. HSV1/2 viral immediate-early entry, early entry, and late entry protein expression were determined by fluorescent antibody staining followed by HSV1/2 glycoprotein B mouse monoclonal antibody and DAPI. Statistical analysis was performed using t-test and data were considered significant when p ≤ 0.05 (GraphPad Prism). HSV1/2 infection under standard aerobic conditions was approximately twice that measured for anaerobically infected cells. In addition, the level of HSV-2 infectivity was significantly (p < 0.05) higher (~8-fold) than that of HSV-1, regardless of oxygen level. HSV entry stage protein expression (ICP8, ICP27, VP5) was detected for anaerobic HSV1/2. A similar pattern was observed for anaerobically grown progeny of HSV1/2, i.e., the number of progeny was higher when anaerobic progenies were grown under aerobic conditions (anaerobic to aerobic) as compared to those grown under anaerobic conditions (anaerobic to anaerobic). In addition, the progeny levels grown solely under anaerobic conditions trended higher for HSV-1 than HSV-2 progeny but were not significantly different. These findings show that HSV1/2 can infect and replicate in anaerobically growing cells and that oxygen is not essential for productive replication.
Impact Of dividend decision on the market capitalization of the firm: Evidence from Indian large cap companies
Authors: Ritesh Patel  , Chintan Baria
Published: April 2023

The percentage of the profit distributed to the shareholders is known as the dividend. The decision at hand is how much of the company's profit should be divided to the shareholders after taxes have been paid. It also contains the portion of the profit that needs to be invested back into the company. The retained earnings boost the company's potential for future earnings when the present income is reinvested. The amount of retained earnings has an impact on the company's choice of financing as well. The decision to declare a dividend should be made with the goal of maximizing shareholder value in mind. The present study attempted to evaluate the impact of dividend decision on the market capitalization using regression model. The regression analysis model revealed the significant impact of the independent variable on the market price of the share as well as the dividend policy determinants on the subsequent market price variable.
Evaluation of fusariosis resistance in commercial onion varieties in Burkina Faso
Authors: Tounwendsida Abel Nana  , Marcel Bembamba  , Adama Sirima  , Kadidia Koita
Published: April 2023

Fusarium head blight is a serious fungal disease that affects various crops, including onions, in many parts of the world, including Burkina Faso. Onion varieties that have been identified as efficient in other areas may not necessarily perform well in Burkina Faso, given the particular environmental and agronomic conditions of the region. Therefore, the aim of this study was to identify onion varieties that demonstrate resistance or tolerance to Fusarium head blight, as well as yield high harvests, in the specific soil and climate conditions of Burkina Faso. To achieve this, seven onion varieties were evaluated during the dry season in Tabtenga, located in the commune of Loumbila. The incidence rates and the severity of Fusarium head blight were assessed at 35 and 75 days after transplanting. The results indicated that the varieties Noflaye, Prema 178, Rouge de Tana, and Super Yali displayed the lowest incidence of Fusarium head blight. However, the severity of the disease was not statistically different across all the varieties tested. Bulb yields ranged from 11.50 to 20.75 tons per hectare. This study is the first to provide data on the resistance of onion varieties to Fusarium head blight in the central agro-ecological zone of Burkina Faso. These findings suggest that the identified varieties may hold promise for sustainable onion production in the region. However, to confirm the results, multi-local trials should be conducted across both dry and rainy seasons.
Importance of the implementation of the S and OP system in modern industries
Authors: Gomes Rickardo  , Ferreira Gustavo
Published: April 2023

In recent years, there has been a growing demand for Supply Chain Management (SCM) to become more agile, integrated, and data-driven, especially with the advent of Industry 4.0. To meet this demand, companies have focused on implementing Integrated Sales and Operations Planning (S and OP) processes, which seek to integrate and align the activities of Sales, Operations, Demand Planning, Supply Planning, and Finance. A qualitative approach was adopted for the development of this research, using a literature review as the investigation procedure. The overall objective of this research is to demonstrate the importance of implementing the S and OP system in modern industries. As a result, an alignment in the company's perception of the level of service expected by the customer is observed, focused on delivery time and commercial conditions, but its process has areas for improvement when viewed in the light of S and OP.
Neonatal Rhabdomyosarcoma: About a new observation
Authors: I. Elouardighi  , I,Zizi  , L. El Iaziji  , N.Amalik  , A. Barkat
Published: April 2023

Rhabdomyosarcoma is a cancer that develops from so-called "soft" tissue. In neonates, as well as in older children, rhabdomyosarcoma is the most common malignant soft tissue tumor. Malignant mesenchymal tumors are, after neuroblastoma, the second most common type of cancer in the newborn. Our case is a female neonate, 2nd of 2 siblings, full term, eutrophic, admitted at H4 of life with respiratory distress rated 2/10 according to the silverman score with left choanal atresia. The oral examination revealed several solid pinkish masses and the cervico-facial CT scan showed an oval retro pharyngeal collection associated with infiltration of the superficial and deep left neck and upper mediastinum spaces. The histopathological study found a morphological and immunohistochemical aspect of an embryonal rhabdomyosarcoma. Rhabdomyosarcoma is rare in the neonatal period, it is located mainly in the limbs, genitourinary tract and head and neck region. As was the case with our newborn who presented with an oropharyngeal location. Their diagnosis can be difficult and requires the advice of an expert anatomopathologist. Their management must be multidisciplinary.
Neonatal cervical group B streptococcal cellulitis
Authors: I Elouardighi  , I Zizi  , L El Iaziji  , N Amalik  , A Barkat
Published: April 2023

Cellulitis of neonates and infants younger than three months of age is rare and often atypical in presentation. Because of the potentially (and rapidly) lethal course of group B streptococcal sepsis, it is essential to avoid delay in diagnosis and treatment. We report the case of a neonate with group B streptococcal retroauricular cellulitis. Admitted for late bacterial neonatal infection with cutaneous location. The history of the disease dates back to one day before admission, with the appearance of a painful cervical swelling without other associated signs evolving in a context of fever of 39°. The clinical examination found a pink tonic reactive newborn in good hemodynamic and respiratory condition, febrile at 39.5°. With the presence of a painful and warm latero-cervical mass of hard consistency and the presence of associated bilateral latero-cervical adenopathies was noted. The oral cavity examination was unremarkable; Cellulitis in newborns and infants under 3 months of age is rare and has not been described in the literature except in a few clinical cases. In the case of any cellulitis of the face in a newborn or before the age of 3 months, late infection with group B streptococci (GBS) should be considered.
Pendampingan Penyandang Disabilitas Angkatan Kerja dalam Mengenal Microsoft Office
Authors: Tri Astari
Published: April 2023

Pendampingan dimaknai sebagai proses perubahan kreatif yang dilakukan oleh masyarakat sebagai bentuk proses inisiatif dan bentuk tindakan untuk menjadi pribadi yang lebih baik. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kapasitas, kemandirian, dan faktor kesiapan kompetensi kerja penyandang disabilitas di dunia kerja di bidang Teknologi, Informasi, dan Komunikasi (TIK), khususnya pengenalan Microsoft Office. Metode pelaksanaan yang digunakan dalam kegiatan pendampingan ini terdiri dari empat tahap: Asset Based Community Development yang disebut “ABCD”. Dalam kegiatan pendampingan, penyandang disabilitas angkatan kerja merasa antusias, senang dan bersemangat dalam melakukan pengem­bangan diri dalam TIK khususnya dalam pengenalan Microsoft Office. Setelah mengikuti kegiatan pendampingan, pengetahuan peserta tentang Microsoft Office: Microsoft Word, Microsoft Excel dan Microsoft PowerPoint dari sebelumnya hanya 17% (2 orang) menjadi 67% (8 orang) serta 50% (6 orang) sudah bisa berlatih dan bereksplorasi secara mandiri.
Pendampingan Siswa dan Guru MI dalam Meningkatkan Kualitas Pembelajaran Matematika di Kecamatan Pulosari Kab. Pandeglang-Banten
Authors: Dwirahayu Gelar , Satriawati Gusni , Sobiruddin Dindin , Fatra Maifalinda
Published: April 2023

Pengabdian kepada masyarakat merupakan salah satu tridharma perguruan tinggi. Prodi pendidikan matematika UIN Syarif Hidayatullah Jakarta melak­sanakan pengabdian Tahun 2022 di Desa Pulosari Kabupaten Pandeglang Banten dengan tujuan: (1) memberikan pendampingan kepada guru-guru MI tentang pendekatan pembelajaran matematika yang mendukung pada kurikulum merdeka belajar (2) memberikan pelatihan tentang literasi matematika bagi guru MI, (3) memberikan pendampingan kepada siswa dalam belajar matematika yang mudah dan menyenangkan. Metode yang digunakan yaitu pendekatan partisipatif, dimana dosen dan mahasiswa ter­libat langsung dalam memberikan layanan masyarakat. Pengabdian dilaksa­nakan pada bulan Agustus tahun 2022 dengan melibatkan 60 mahasiswa, 9 dosen, 57 guru MI yang berasal dari 19 MI dan siswa-siswi sebanyak 22 kelas. Hasil pengabdian menunjukkan bahwa 1) Mahasiswa memiliki pengalaman langsung dalam mengimplementasikan strategi pembelajaran di kelas; 2) Siswa merasa terbantu dalam belajar matematika, mereka lebih interaktif belajar, siswa juga merasakan bahwa matematika itu tidak sulit; 3) Sebagian besar guru MI di kecamatan Pulosari belum memahami tentang implementasi pendekatan problem based learning dan project based learning; 4) Sebagian besar guru MI di kecamatan Pulosari masih mengalami kesulitan dalam membuat soal HOTS,  5) sebagian guru tidak dapat menyelesaikan soal literasi; dan 5)  guru memberikan respon positif terhadap pelaksanaan kegiatan pengabdian.
Recensione di De loin à rien
Venezia, Fondazione Ugo e Olga Levi, 24 febbraio 2022
Authors: Dobrucka Anna
Published: April 2023

Concerto in occasione del International Festival Japan Contemporary Arts in Venice The Aesthetics of Emptiness.
Il cinema e la gioventù nelle decadi perdute
Authors: Novielli Maria Roberta
Published: April 2023

In the last thirty years, starting from the collapse of the bubble economy, the long period of economic and political crisis defined as the ‘lost decades’ has resulted in a strong social impact with a severe fallout in particular on the younger generations that have followed since that moment. For them, it has been lacking the solid structure characteristic of the previous decades thanks to which, starting from the period of school education, it was possible to aspire in the future to a certain profitable job, therefore with the possibility of creating a family and harmoniously inserting themselves into a given social structure. Many elements of maladjustment, in some cases even pathological as in the case of hikikomori or the frequent perpetrators of ferocious criminal acts, have obviously been re-proposed by cinema, an art that is always sensitive to contemporaneity. This essay, therefore, offers an overview of the main film trends developed in the archipelago in the last thirty years and linked to the world of the youngest and their widespread sense of existential emptiness.
Breeding value of drought-resistant sterile sorghum lines
Authors: Kibalnik O. P. , Larina T. V. , Kameneva O. B.
Published: April 2023

Currently, breeders often use multidimensional statistics methods to process a large set of experimental data. To characterize the breeding value of 20 sorghum lines with cytoplasmic male sterility (CMS lines) under arid cultivation conditions, during the research there was applied a cluster analysis, allowing to group the lines into clusters according to similar indicators from 15 analyzed agronomic and physiological characteristics. The studies were carried out during 2019-2021, various in meteorological conditions: the hydrothermal coefficient was 0.59-0.84 during the vegetation period of plants. Cytoplasmic male sterility lines were sown at a density of 100 thousand plants per 1 hectare. Breeding and physiological traits were evaluated according to generally accepted methods. The assessment of agronomic and physiological characteristics was carried out according to generally accepted methods. For further practical work, based on the results of the conducted studies, four CMS lines of grain sorghum (clusters 2, 3, 5) were identified according to a complex of physiological and breeding characteristics. Sterile lines (A2 Vostorg, M35-1А Pischevoe 614, A3 Feterita 14 and A2 KVV 114) were distinguished by the highest seed yield of 3.02-3.50 t/ha, high water content (72.7-73.7 %) and water retention capacity of leaves (72.2-84.3 %), low water deficiency (6.5-8.7 %). The study of moisture loss during the natural wilting of leaves confirmed the high resistance to drought in the flowering phase of the sterile A2 KVV 114 line, in which the intensity of moisture loss after 1 hour was only 9.9 %, 1.5 h – 15.8 % and 24 h – 68.6 %. In breeding for increasing drought resistance the CMS-line A1 Efremovskoe 2 (the sixth cluster) should be noted, as it was inferior to the above-described lines only in terms of low water deficiency (16.5 %), indicating average drought resistance. The line is the tallest with large leaves (length – 46.7 cm, area – 163.8 cm2) and form 3.21 t/ha of seeds on average for the period presented. The use of the obtained data provides the increasing of the breeding process for the creation of productive drought-resistant F1 sorghum hybrids.
Interchangeability of hunts as a factor of sustainability of hunting use
Authors: Matveytchuk S. P. , Grebnev I. A.
Published: April 2023

The purpose of the study is to develop in hunting management the approaches to identifying, evaluating and accounting the socio-ecological phenomena of hunter specialization (by types of hunting, game caught) and the interchangeability of hunts, taking into account the presence of a market sector in the area under consideration. The research used the methods of interdisciplinary analogies and semi-structured interviews in addition to general scientific methods. A comparison of hunts close in formal characteristics was made, their significant differences were revealed. It is noted that comparisons can be made for many hunts, and their quantitative and qualitative differences will be more significant. The wide distribution and relative stability of hunters' preferences are shown. A definition of the concept of hunt interchangeability has been developed.   The structural elements of this definition determine the algorithm of practical survey, which is necessary at the design stage of changing the protection regime and the use of hunting resources. Recommendations are given on the practical analysis  of the interchangeability of hunts practiced in certain areas, the inclusion of the results in strategic planning documents and the consideration in planning management decisions that provide for the prohibition of separate hunts. It is pointed out that ignoring the phenomenon of hunters' specialization when setting hunting restrictions can lead to a complete or partial loss of this hunt, related knowledge, abilities and skills. Especially dangerous is the loss of highly specialized hunts, including the use of specially bred decoying and catching animals. Other undesirable consequences may be a reduction in the social base of hunting in general, as well as an increasing protested or constrained poaching. The combination of these and other negative phenomena creates a threat to the sustainability of the use of hunting resources.
Improving the energy efficiency of wind turbines for charging batteries
Authors: Petko V. G. , Rakhimzhanova I. A. , Ushakov Yu. A. , Fomin M. B. , Baikov A. S. , Pushko V. A.
Published: April 2023

The article describes the method for determining the optimal angular velocity and the number of turns of the generator winding on permanent magnets powered by a wind turbine operating in specific operating conditions according to the wind speed regime. The optimization criterion is the maximum potential of energy that can be used to charge the battery. The permissible power of the generator and wind turbine, current and battery charging voltage are accepted as limiting factors. The restriction is provided by connecting a ballast resistor to the generator output. The power developed by the turbine is determined taking into account the wind energy utilization factor, which depends on the angular velocity of its shaft and wind speed. Two variants of power limitation are compared: by limiting the angular velocity by aerodynamic means and by stopping the wind turbine. The return of energy to charging in both cases is determined taking into account the distribution of wind speeds, obeying the Weibull probability distribution law. As an example, the calculation of the possible annual power generation for charging a battery with a capacity of 200 A∙h with a voltage of 24 volts from a synchron generator with a number of poles of 48 driven by a wind turbine with a radius of 2 meters, operating in an area with an average wind speed of 5 m/s. The calculation shows that for the parameters and operating conditions of the electrical installation used in the example, the maximum annual energy output (3.3 × 103 kWh) is observed at optimal 11 turns of the winding at each of the poles of the generator. The deviation of the number of turns from the optimal one in both directions by 2 times leads, with the same dimensions of the wind turbine, to a decrease in annual energy output by 3...5 times, which is a clear proof of the need to carry out such a calculation for each specific wind turbine.
The Effect of Social Situations on Risky Decision-Making in Individuals With Borderline Personality Tendency
Authors: Lee Min-Jo , Kwon Young-Sil , Hyun Myoung-Ho
Published: April 2023

Objective This study examined the effect of social situations on risky decision-making in individuals with a borderline personality tendency (BT).Methods Fifty-eight participants with either high or low levels of BT were included in this study. Those who met the screening criteria were assigned to one of the two social situations (exclusion vs. inclusion) and they played the Cyberball game. Next, the participants were required to play the “Game of Dice” task to measure their decision-making pattern.Results The results revealed that individuals with high BT (n=28) showed significantly higher risky decision-making, compared with low BT (n=30) in the exclusion condition. However, no significant difference was found in the social inclusion condition.Conclusion In the social exclusion condition, individuals with high BT made risky decision in response to negative feedback, regardless of the previous decision. These findings can be applied to develop appropriate interventions in psychotherapy for individuals with borderline personality disorder/tendency.
The Effectiveness of Virtual Reality Intervention for COVID-19-Related Psychological Distress: A Systematic Review
Authors: Lee Seul-Ah , Heo Simyang , Kim Somin , Park Chaeyeon , Jung Yujin , Ji Garam , Lee Hyeon-Ah , Kim Kibum , Kim Sungkean , Kim Bin-Na , Kim Ji Sun
Published: April 2023

Objective The prolonged coronavirus disease-2019 (COVID-19) pandemic is likely to cause psychological distress in people. This systematic review aimed to identify the effectiveness of virtual reality (VR)-based psychological intervention among individuals with psychological distress during the COVID-19 crisis. PubMed, Ovid MEDLINE, Cochrane Library, Web of Science, Embase, and PsycINFO databases were searched for articles published until July 2022.Methods The available citations were deduplicated and screened by two authors using the title and abstract information. Eligibility criteria were constructed according to the PICOT guidelines. Empirical studies of all designs and comparator groups were included if they appraised the impact of an immersive VR intervention on any standardized measure indicative of psychological distress (stress, anxiety, depression, and post-traumatic symptoms) or improvements in quality of life in participants, including COVID-19 patients, medical staff working with COVID-19 patients, and people who had experienced strict social distancing during the COVID-19 pandemic.Results The results were discussed using a narrative synthesis because of the heterogeneity between studies. Seven of the studies met the inclusion criteria. There were two randomized controlled trials and five uncontrolled studies on VR interventions.Conclusion All studies reported significant improvement in a wide range of psychological distress during COVID-19, ranging from stress, anxiety, depression, and post-traumatic symptoms to quality of life, supporting the efficacy of VR-based psychological intervention. Our results suggest that VR intervention has potential to ameliorate COVID-19-related psychological distress with efficacy and safety.
The Pharmacokinetics of Subcutaneous Methylnaltrexone Bromide in Rhesus Macaques (Macaca mulatta)
Authors: Jepkes Sarah , Josee-Lemoy Marie , Knych Heather , de Lucena Thiago , Ardeshir Amir , Stockinger Diane E
Published: April 2023

Opioids are an integral component of pain management for nonhuman primates. These potent analgesics also adverse gastrointestinal (GI) effects that include constipation, bloating, and delayed gastric emptying. Methylnaltrexone bromide (MNTX) is a selective, peripherally acting μ-
and κ-opioid receptor antagonist that can be used to mitigate the GI effects associated with opioid administration. Unlike naltrexone, a similar drug in this class, MNTX possesses an N-methyl-quaternary amine group that prevents it from crossing the blood brain barrier. This blockage
allows inhibition of peripheral GI opioid receptors without affecting opioid-mediated analgesia in the central nervous system. We conducted a pharmacokinetic analysis of MNTX in serum and CSF of 6 healthy juvenile male rhesus macaques after subcutaneous administration of a 0.15-mg/kg dose.
We hypothesized that the macaques would demonstrate a Tmax of 0.5 h, similar to that of humans, and that no MNTX would be detected in the CSF. This treatment resulted in a peak serum concentration of 114 ± 44 ng/mL at 0.25 ± 0.00 h; peak CSF at concentrations were
0.34 ± 0.07 ng/mL at the Tmax. These data show that subcutaneous administration of MNTX to rhesus macaques may block peripheral adverse effects of opioids without interfering with their central analgesic effects.
ESTIMATION OF POWER CONSUMPTION OF MOBILE DEVICES IN CLOUD COMPUTING
Authors: Mamchych Oleksandr , Volk Maksym
Published: April 2023

Modern computing tasks require an increase in computing power. This necessitates the creation and production of new equipment for cloud computing. At the same time, the number of personal mobile devices is already measured in billions, and even their partial use could reduce production requirements. In addition, mobile hardware is more energy efficient, which contributes to significant energy savings. The article investigates the issue of qualitative and quantitative assessment of the efficiency of using mobile devices for computing compared to traditional stationary solutions. The purpose of the work is to substantiate the following hypothesis: computing in the cloud based on mobile devices significantly reduces energy consumption than computing on stationary equipment. For this purpose, we show that computing on a mobile GPU is more energy efficient than computing on a stationary processor. Public sources and benchmarks were analyzed to determine the qualitative advantage. On the basis of the studied data, efficiency indicators for various mobile and desktop GPUs are calculated. It is argued that in most cases, mobile solutions consume significantly less energy compared to desktop solutions. To calculate the quantitative advantage, an experiment was conducted on the basis of two platforms: mobile and desktop. The same computational task was implemented using Apple Metal and NVidia CUDA. Based on this task, the energy efficiency indicators of the mobile and stationary graphic professor were calculated. According to the results of the study, a significant advantage of the mobile GPU in terms of energy efficiency has been determined. This result is relevant because the platforms were released in the same year with a difference of several months, so they can be considered peers of each other. The approaches presented here do not take into account the consumption of all other parts of the system, except for the GPUs. This means that the consumption of the motherboard, power supply, etc. can tilt the balance in favor of the mobile processor even more. But for distributed computing, the network connection is very important, and it can consume a significant amount of power on a mobile device. Further research will focus on a more comprehensive accounting of the energy consumption of various computer subsystems.
METHOD OF INCREASING THE EFFICIENCY OF THE WATER SUPPLY NETWORK DUE TO ITS ZONING
Authors: Matviienko Olha , Spichak Polina
Published: April 2023

The goal of the work is to use a stochastic model of quasi-stationary modes of water supply network to reduce excess pressure in the water supply network by establishing pressure regulators at the entrances to the selected zones. The subject of research in the article is the optimization of the structure of water supply network by zoning. The article discusses the task of optimal zoning of water supply networks, which consists of two subtasks: allocation in the water supply network of isolated zones of nodes with excess pressure exceeding a given value; calculation of the parameters of pressure regulators installed at the entrances to the selected zones. A method based on the breadth-first search method is proposed for zone selection. The deterministic equivalent of this problem is solved using the Newton and Nelder-Mead methods. As a result of solving this problem, we obtain the minimum required values of the pressures stabilized at the outlets of the regulators and the maximum allowable values of the flow rates through them. To determine the minimum and maximum values of the ranges of flow rates and pressures at the inlets and outlets of the regulator, the forecast of the maximum and minimum water consumption by all categories of consumers in the selected zone is carried out and the problem of optimal load distribution between the pressure regulators is solved. As a result, we obtain a range of changes in the optimal flow rates through the regulator and the values of pressure stabilized at the output of the regulator. Based on this information, the type of regulators is determined that provides the necessary ranges of pressure changes at the inlets and outlets of the regulators for the minimum and maximum predicted costs through the regulator and the minimum allowable pressure at its inlet. The following results were obtained: calculations show that, using zoning and installation of pressure regulators at the inlets to isolated zones of the water supply network of the structure under consideration, it is possible to reduce the mathematical expectation of the total excess pressure in the network by 21%. Conclusions: the paper proposes a mathematical model for the problem of optimal zoning of the water supply network, based on a stochastic model of quasi-stationary modes of its operation, and a method for solving this problem. A computational experiment carried out for a water supply network of a given structure showed that as a result of installing pressure regulators at the entrances to the selected zones, it is possible to increase the efficiency of its operation.
OPTIMISATION OF TARGET INDICATORS OF THE PROJECT PORTFOLIO FOR TRANSPORT AND LOGISTICS SUPPORT OF TOURIST CENTRES
Authors: Khodikova Inna
Published: April 2023

The subject of the study is modelling the optimal target indicators of the portfolio of projects for transport and logistics support of tourist centres. The aim of the study is to improve the efficiency of portfolio management processes for the development of transport and logistics support for tourist centres. Tasks: 1) to develop a conceptual model for harmonising targets / parameters of project products for the portfolio of projects for the transport and logistics support of tourist centres; 2) to determine the mathematical description of the main indicators as functions of the parameters of transport and logistics support of tourist centres; 3) to develop a mathematical model for determining optimal and consistent targets for the portfolio of transport and logistics support of tourist centres. Research methods are: methodology and methods of system analysis, methods of operations research. The following results were obtained: the concept of "hierarchy of tourist centres" was introduced, which is a logistics system that is linked to the relevant transport hubs. To manage transport and logistics projects as part of the portfolio, a conceptual and appropriate mathematical model has been developed to determine the optimal and consistent target indicators of the portfolio of transport and logistics projects for tourism centres as part of the hierarchy. The coordination is formed at the level of tourist flows, taking into account their possible distribution among tourist centres, as well as a single source of funding. The model's control parameters are the necessary indicators of the increase in the capacity and quality of service of transport and logistics systems of tourist centres of the same hierarchy. The objective function of the model reflects the maximisation of the economic effect of implementing projects to improve capacity and quality. The constraints take into account funding opportunities, investment efficiency, goals for the development of tourist flows in each centre, and the conditions for coordinating tourist flows in the centres of the same hierarchy (or part of it). The results obtained take into account the peculiarities of forming economic indicators for the hierarchy of tourist centres and form the basis for assessing the value of transport and logistics projects for tourist centres. Conclusions: The results of the study are a conceptual and appropriate mathematical model that allows to form optimal and consistent parameters of the products of projects for the integrated development of transport and logistics support for tourist centres. The model takes into account the peculiarity of the parameters of transport and logistics support, but its structure and construction principle can be used to form models for optimising and coordinating the target indicators of portfolio projects whose products are interdependent.
INVESTIGATION OF THE TECHNICAL CONDITION OF WATER DISCHARGE DEVICES OF HYDRAULIC STRUCTURES
Authors: MAKOVETSKYI B. , DIACHENKO О. , TROSHYN М.
Published: April 2023

Problem statement. Hydrotechnical structures undergo a process of inspection for their technical condition. This is necessary to maintain the durability of the structure. In the process of operation, structural defects occur, which are difficult to examine and investigate, due to the impossibility of access for visual inspection. Such defects include those formed in the body of gravity-type earth dams. This applies, first of all, to structures and devices that are located in the body of dams during their construction. They include, in particular, spillways and pipelines. Defects in these structures lead to leakage of water into the body of the dam, which eventually collapses from the inside. Timely detection of defects prevents the destruction of dams due to urgent repairs, and this extends the durability of the structure. The purpose of the article is to develop an analytical-instrumental method of finding, without destroying the body of the dam, erosional, loosened areas in leakage zones, and determining their volumes. Method. A modern method of geophysics, which is electrotomography, is used. As a theoretical justification, the method of the Earth's natural pulsed electromagnetic field (MENPEF) was taken as a basis. The result of the research is the development of a methodology using the methods of engineering geophysics: the method of the Earth's natural pulsed electromagnetic field (MENPEF) and geoelectric tomography. Scientific novelty lies in the fact that the method was developed for the first time for the examination of earth dambs spillways. Practical value. With the help of the developed method, in the future it will be possible to conduct surveys for earth dams of hydrotechnical structures for all organizations that are engaged in such work and have the necessary tools. Conclusions. An analytical-instrumental method of researching the sections of earth dams that cross the structures of ponds spillways and reservoirs has been developed. The location of the loosened soil halo around the spillway pipes inside the body of the earth dam was identified, and the volume of such soil was determined.
OPTIMIZATION OF SUPERVISORY ACTIVITY REGARDING ANALYSIS AND ACCIDENT RECORD ON ENTERPRISES BY MEANS OF DATABASE CREATING
Authors: SOKOLAN Yu. , ROMANISHINA О.
Published: April 2023

Problem statement. Supervisory activities on analysis and accounting of accidents in the enterprise are conducted by the bodies of the State Labor Service and working bodies of the Fund in accordance with their competence by controlling the timeliness and objectivity of accident investigation, preparation of investigation materials, record keeping, taking measures to eliminate the causes of accidents. The processing of relevant statistical information involves a large volume of data and documentation. One of the methods to minimize errors in the work of the occupational safety engineer is the use of enterprise databases, where all the necessary information will be stored and processed. The purpose of the article is to create an optimized database with functionality for registering accidents and analyzing occupational injuries in order to optimize the supervisory activities of the relevant authorities and individual productions. Conclusions. In the course of supervisory activities to analyze and account accidents in an enterprise, representatives of the above bodies study and check a large number of documents. The main drawback of using such a database is that it does not implement an automatic document flow when maintaining documentation on accident investigation. But this approach simplifies the work on the abundance of information on the registration of accidents and occupational diseases, allows the analysis of occupational injuries, preserves the integrity of data, minimizes the human factor and, consequently, reduces the number of errors. This approach is one of the possible ways to solve the problem of the lack of appropriate specialized software.
An Auto-ethnography of the Process of Establishing Subjectivity of the Body
Authors:   Korean Association for Qualitative Inquiry, Park Hyeji
Published: April 2023

The purpose of this study is to show the experience and reflection on how my body has established its subjectivity in the personal, familial, and social boundaries of each stage of life development. The research question is ‘what I have reflected through the experience of the body in the process of life development?’. As a research method, the auto-ethnography was used. In order to collect research data, diary, personal counseling journal, program records, and writings for literary creative contests were collected based on self-recall materials. Then organized and signified according to the research theme. As a result of the data analysis, the subjects of the body according to the stages of life development were named as ‘childhood - the rough body of a great tomboy’, ‘adolescence - the shameful body trapped in the gaze of others’, ‘the young adulthood - the body of the struggle for recognition in the bridle of society’, and ‘middle age - the body that accepts me, others and society’. Through the research process, the researcher has noticed the transformation of beings who want to pursue life from ‘instrumentalized body’ to ‘expanded body’, and intends to carry out self-care to apply it to the everyday world. Based on the results, this study suggests ways to support children and adolescents to form an autonomous and positive image of their bodies.
A Phenomenological Study on Reflective Writing Experiences of Novice Counselors
Authors:   Korean Association for Qualitative Inquiry, Park Taihwa , Kim Myeongchan
Published: April 2023

The purpose of this study is to provide basic information needed for the reflection of novice counselors in the future by looking at the experiences of novice counselors’ reflective writings. For this purpose, nine interviewees who had experienced reflection writing by applying Giorgi’s phenomenological research method were interviewed and analyzed. Data analysis showed 531 meaningful units, 15 subcomponents, and 5 final components. The results of this study are as follows: ‘Recognize inner emotions and comfort oneself’, ‘Experience interactions with deeper relationships’, ‘Pursue mature life and professional growth’, ‘Seeing oneself’, and ‘Getting a feeling of control through integrated experiences’. Through this study, it can be meaningful to reveal the essential structure and process by studying introspective counselor’s experience of introspective writing in depth. It can also be expected that reflection writings can be used as a basic data for self-reflection of a counselor and help to improve and promote professionalism.
Autothnography on The experience of running a Village Curriculum in a Small School in a Rural Village
Authors:   Korean Association for Qualitative Inquiry, Hwang Mijin , Hwang Yoojin
Published: April 2023

The purpose of this study is to examine an elementary school teacher’s educational experience of running a small-scale village curriculum in rural and fishing villages using the autoethnography method. in the search for meaning and value. The research results are briefly presented as follows. First, is there really learning in a classroom without questions? The contemplation of “Future” led to the conclusion that the true meaning of learning should begin with helping and caring for the existence and life of children. Second, the answer to their concerns was transferred to a small school in a farming and fishing village, where they got out of textbooks and experienced classroom lessons that they had long dreamed of through classes with children’s curiosity. Third, it was found that Saetbyeol, who started making eye contact with friends through village outings, expanded her interests to the surroundings and learned not only empathy but also how to build relationships. The researcher, who was convinced of the educational experience through the village outing, ran a village curriculum with children who had the power to learn from early March, and the educational experience conducted as a class with the teaching staff, parents, and village elders on the theme of Chuseok was a solidarity with the village community. It was an important practice to create a cultural foundation through. Fourth, the researcher who visited the village he lived in as a child saw who he was through the place and experienced recovery through the process of comforting himself while facing his painful past.
A Narrative Study of Parental Divorce on Marriage in Adult Woman
Authors:   Korean Association for Qualitative Inquiry, Lee Soobin , Jo Hang
Published: April 2023

This study explored the experience and meaning of married life of adult women who experienced parental divorce through narrative inquiry. For this, we conducted several in-depth interviews with an adult woman who experienced parental divorce before reaching adulthood to investigate her stories related to parental divorce before marriage, her experience until marriage after becoming an adult, and her experience of marriage and parenting. The results of this study derived from the participant’s stories included the following four main themes: , , , . This study is meaningful in that it examines in depth the experiences of adult women’s married life who have experienced parental divorce. Specifically, the results of this study can be used for education and counseling programs for prospective couples to adapt to married life, and can be used as basic data that can help couples considering divorce for healthy divorce and social adaptation.