bluuebunny/crossref_metadata_2025 huggingface dataset:
Síndrome de Guillain-Barré em paciente pediátrico: relato de caso e revisão da literatura
Authors: Maranho Laura Schwartz , Ribas Guilherme Weiss , Bandeira Marcia
Published: May 2016

A síndrome de Guillain-Barré é uma neuropatia periférica desmielinizante aguda e é a causa mais comum de paralisia flácida. Caracteriza-se por fraqueza muscular progressiva, ascendente, bilateral e simétrica das extremidades. O objetivo deste trabalho é relatar o caso de uma paciente, 12 anos, sexo feminino, com diagnóstico de neuropatia axonal aguda motora e com alteração eletrofisiológica.
Editorial
Authors: Carvalho Mauricio
Published: May 2016

Inicia-se com este número o ano 3 da Revista Médica da UFPR (RMU). A missão da RMU, como política editorial, baseia-se na promoção e disseminação do conhecimento médico. Ela é voltada a todos com interesse em ciências da saúde, principalmente a acadêmicos de medicina, médicos, professores e outros profissionais da saúde. É claro que todo autor, ao enviar seu artigo para publicação, busca divulgação, reconhecimento e visibilidade de seu estudo. Para aumentar a visibilidade da RMU, nosso objetivo é buscar o mérito científico, aprimorar os critérios de aceitação e manter a periodicidade. Com isso, podemos nos candidatar a indexação nas diversas bases (Index Medicus, Lilacs, SciELO, etc.) e a avaliação pelo sistema Qualis de periódicos científicos. Sem sombra de dúvida, um trabalho para algumas gerações. Mas, toda grande jornada começa com um primeiro passo.  Guimarães Rosa já dizia em seu clássico Grande Sertão: Veredas, que a vida pede coragem. Somos uma revista registrada, vamos em busca das indexações.Realço nesta edição o trabalho de pesquisadores da Pontifícia Católica do Paraná (PUCPR) que avaliaram uma coorte de 983 portadores de diabetes mellitus tipo 2, atendidos nas unidade de saúde pública de Curitiba. Os autores quantificaram o impacto desta afecção na qualidade de vida destes pacientes. Os resultados demonstraram forte impacto nos aspectos social, físico e emocional, principalmente naqueles com mais de 10 anos de doença e em uso de insulina.Um relato de caso também merece destaque. Trata-se da descrição de provável síndrome de Guillain-Barré em um paciente de 12 anos de idade. De particular interesse é a relação desta afecção com as arboviroses (Dengue; Chikungunya e Zika) em nosso país. Por este motivo, a Secretaria de Estado da Saúde do Paraná implantou um protocolo de vigilância (http://www.saude.pr.gov.br/arquivos/File/SESA_PR_Protoc_Vigil_Sind_Neuro_14_03_2016.pdf, acessado em 26.03.2016) de casos de Síndrome de Guillain-Barré e outras doenças neurológicas agudas graves pós-infecciosas. De acordo com este protocolo, o caso aqui relatado seria considerado como suspeito.Boa leitura,
Neoplasia e dispneia
Authors: Pereira Marcos Vieira Rangel , Neves Filho Marcos Marcelo , Oliveira Evandro Tito , Moribe Daniele Micima
Published: May 2016

Caso Clínico: Homem de 74 anos, hipertenso, adenocarcinoma de próstata confirmado por biópsia em 2014 e condrossarcoma de fêmur direito confirmado por biópsia em 2009 após início de dor intensa na articulação coxo-femoral associado a tumoração local com aumento progressivo. Neoplasia metastática pulmonar confirmada logo após diagnóstico de condrossarcoma. Relatava dispneia aos grandes esforços há aproximadamente 6 anos, com piora lenta e progressiva, se tornando aos moderados esforços no último ano. Quinze dias antes do internamento apresentou dispneia aos mínimos esforços e em repouso, com piora abrupta dos sintomas. Apresentava tosse crônica, sem alteração do padrão no período. Negava dor, febre, hemoptóico ou outras queixas. Ao exame físico, apresentava-se taquidispneico com esforço respiratório e uso de musculaturas acessórias evidentes, agitado e desconfortável no leito. Murmúrio vesicular reduzido em base direita e com crepitantes em terço médio e base esquerda, além de sibilos inspiratórios difusos. Evoluiu a óbito cinco dias após a admissão hospitalar. Antes do óbito, uma angiotomografia de tórax havia sido realizada. Qual o diagnóstico?
Investigating the Role of Multiple Intelligences in Determining Vocabulary Learning Strategies for L2 Learners
Authors: Sistani Mahsa , Hashemian Mahmood
Published: May 2016

This study, first, examined whether there was any relationship between Iranian L2 learners’ vocabulary learning strategies (VLSs), on the one hand, and their multiple intelligences (MI) types, on the other hand. In so doing, it explored the extent to which MI would predict L2 learners’ VLSs. To these ends, 40 L2 learners from Isfahan University of Technology in Isfahan participated in the study, and the following instruments were utilized to collect the data: the Oxford Placement Test (OPT) to gauge participants’ proficiency level, the Multiple Intelligences Questionnaire (Mckenzie, 1999), and a vocabulary learning questionnaire based on the framework adopted from Schmitt’s (1990). The strategies were divided into five categories: determination, memory, social, metacognitive, and cognitive. To analyze the data, Pearson correlation was applied to find out the relationship between the participants’ intelligence categories and their preferred VLSs. Then, multiple regression analysis was run to indicate the significance of the specific VLSs in the participants’ intelligences. Results revealed that there was a strong positive relationship between participants’ intrapersonal intelligence and their tendency toward the cognitive and metacognitive strategies. Moreover, as participants’ scores in their interpersonal intelligence test increased, they inclined toward the social strategies more. A potential positive and significant relationship between visual/spatial intelligence and memory strategies and also linguistic intelligence and determination strategies was also found out. Overall results revealed that the participants made a significant difference regarding their decisions for particular VLSs, as intrapersonal, interpersonal, linguistic, and visual learners predicted more specific and significant VLSs in comparison with other types of intelligences.
Multiplexed Biosensors for Mycotoxins
Authors: Maragos Chris M
Published: May 2016

Significant progress has been made in the development of biosensors that can be used to detect low-MW toxins produced by fungi (mycotoxins). The number of formats that have been investigated is impressive and is an indication of the importance attached to finding easy-to-use, accurate, and rapid methods for detecting these toxins in commodities and foods. This review explores the details of multiplexed biosensors based on many formats, including multiplexed immunoassays, suspension arrays, membrane-based devices (flow-through and immunochromatographic), and planar microarrays. Each assay format has its own strengths and areas that need improvement. Certain formats, such as multiplexed immunochromatographic devices, are well developed and relatively easy to use, and in some cases, commercial products are being sold. Others, such as the suspension arrays and microarrays, are laboratory-based assays that, although more complicated, are also more amenable to a larger scale of multiplexing. The diversity of such efforts and the multitude of formats under investigation suggest that multiple solutions will be found to satisfy the need for multiplexed toxin detection.
The word that did (not) escape: Ovde [here] and tamo [there]
Authors: Miloradović Sofija
Published: May 2016

This contribution first establishes a link between Paraćinsko Pomoravlje and Kosovo and Metohija through the poetics of five dialect texts. Then, via the antonymically positioned adverbial pair ovde and tamo, it draws attention to the contrast between the present place of residence and the past homeland, between the homeland and the foreign land, this world and the otherworld. The concerned two words are key words of sorts, describing the life of individuals and families - not merely in space but in time as well, and including their way of life. The basic lexicographic definition of the adverb ovde is 'here, in this place', and of the adverb tamo 'there, in that place', but in the story of our sufferers, tamo denotes the homeland, the place they were exiled from, and therefore - something familiar and close, while in two other cases the word tamo symbolizes something distant, unknown and frightening - foreign lands and death. Additionally, however, the secondary dictionary meaning of the adverb ovde - 'here, towards this place', linked to verbs of motion, reflects the speakers' migrations to some future places of residence.
The interpretation of Huntington's thesis of clash of civilizations as a tribal conflict of global proportions
Authors: Nedeljković Zoran
Published: May 2016

The author of this paper attempted the interpretation of Huntington's thought that the clash of civilizations is tribal conflict of global proportions. In the first interpretation of the conflict, we think of civilization as a tribe in conflict with the other tribes, they mutually perceive each other as barbarians, denouncing each other's civilizational identity. In the second interpretation, the clash of civilizations is perceived as a clash of postmodern immigrant groups (tribes) with the dominant culture of the local population within a state. In the age of the universal conflict, we see Huntington's pessimistic view of the social world and the temporary man, whom we characterize as a synthesis of immigrants, migrants and foreigners, as a kind of personification of the spirit of the times of postmodern twenty-first century.
A few examples of opposed thinking about gender differences
Authors: Redžić Saduša
Published: May 2016

Examples of anti-feminine and pro-feminine reasoning with Otto Weininger, Jean-Jacques Rousseau, Sigmund Freud, Arthur Schopenhauer, Aristotle, Simone de Beauvoir, Pierre Bourdieu, Harriet Taylor Mill and John Stuart Mill. Review of these theories points to the need to respect distinction (physical) characteristics of sex and (culture defined) characteristic of the gender when analyzing differences and similarities between the sexes, as well as the need for insight into the mechanism (or mechanisms)of connection between the nature of social perception and gender stereotypes, whose existence is an indicator, and one of the causes of hatred towards women.
REGIONALNA POLITIKA EVROPSKE UNIJE
Authors: Čehulić Vukadinović Lidija , Aulić Ljiljana
Published: May 2016

Država kao subjekt međunarodnih odnosa razvija se i napreduje upovoljnim i stabilnim političkim i ekonomskim uslovima. Na žalost, svjedoci smosvjetske ekonomske krize, koja ima velike posljedice na sve strukture društva iimplicira političke probleme u kojima BiH treba da sprovodi proces evropskihintegracija. To je otežavajuća okolnost, ne samo za Bosnu i Hercegovinu veći i zaEvropsku uniju koja nastoji umaniti posledice i trasirati dalje puteve proširenja.Regionalna politika EU značajna je za sve zemlje članice i zemlje koje teže evropskojporodici, što se posebno odnosi na zemlje Zapadnog Balkana, koje su u procesupolitičkih i socijalnih promjena. Uticaj regionalne politike Unije ne treba precjenjivati,ali ni potcjenjivati, s obzirom da se države članice bore za finansijsku pomoć kojadolazi iz strukturnih fondova. Istina, novac jeste pokretačka snaga napretka, ali beznacionalne i evropske politike, sa dobrom nacionalnom makroekonomskom politikomnema uspjeha. Pitanje je da li se mogu ostvariti željeni rezultati i povećati pozitivniučinci drugih politika bez regionalne politike koja stvara uslove za pozitivne efekte,konkuretnost regiona i time obezbjeđenja kvalitetnog životnog standarda građana.
POLITIČKI KONSALTING I LOBIRANJE
Authors: Milutinović Milovan
Published: May 2016

U mnogim krugovima vršenje uticaja lobiranjem smatra senetransparentnim političkim procesom i sumnjivim poslom, koji graniči sa korupcijom.Neki veruju da se iza političkog konsaltinga i lobiranja krije nelojalna konkurencija,kriminal ili podmićivanje. Zastupanje interesa na nacionalnom i na evropskom nivousastavni је deo političkog konsaltinga. U radu će biti predstavljeni akteri, institucije ioblici lobiranja na nacionalnom i evropskom nivou i uticaj na donošenje prihvatljivihodluka. Težište je usmereno ka radu lobista, čija aktivnost teži transparentnosti ivisokoj profesionalnosti. Tu je lobiranje legitiman vid zastupanja interesa klijenata,koje doprinosi interesima klijenata kao i opštem dobru, zbog čega se na određen načinmože govoriti o pluralizmu interesa modernih demokratija savremenog sveta, kako naunutrašnjem, tako i na međunarodnom planu.
ИНТЕЛЕКТУАЛНИ РАЗВОЈ ДЕТЕTА – ОД ШКРАБАЊА ДО ПУНОГ ЛИКОВНОГ ИЗРАЗА
Authors: Дивљан Сретко
Published: May 2016

Онтогенеза ликовног израза код савременог детета може сеупоредити са филогенезом ликовности код пећинског човека који је имао истепроблеме на свом развојном сликарском путу као и дете. Потребно је да тај путпроучавамо на основу фактора опште и фактора креативне интелигенције. Дабисмо унапредили ликовну уметност, морамо проучавати историју уметности каои развој дечјег ликовног рада, јер је то суштина једног бољег сутра. Да бисмодете одгојили у савремену особу, која се поштује и верује у себе, употребићеморазличите похвале усмерене на особу. Вера и воља су суштина креативне снагедетета. Критику рецимо детету што пре.
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis
Authors: Patterson Stephen , Wyllie Susan , Norval Suzanne , Stojanovski Laste , Simeons Frederick RC , Auer Jennifer L , Osuna-Cabello Maria , Read Kevin D , Fairlamb Alan H
Published: May 2016

There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683), an approved drug for multi-drug resistant tuberculosis, is a potent inhibitor of Leishmania donovani both in vitro and in vivo. Twice-daily oral dosing of delamanid at 30 mg kg-1 for 5 days resulted in sterile cures in a mouse model of VL. Treatment with lower doses revealed a U-shaped (hormetic) dose-response curve with greater parasite suppression at 1 mg kg-1 than at 3 mg kg-1 (5 or 10 day dosing). Dosing delamanid for 10 days confirmed the hormetic dose-response and improved the efficacy at all doses investigated. Mechanistic studies reveal that delamanid is rapidly metabolised by parasites via an enzyme, distinct from the nitroreductase that activates fexinidazole. Delamanid has the potential to be repurposed as a much-needed oral therapy for VL.
Cell-specific synaptic plasticity induced by network oscillations
Authors: Zarnadze Shota , Bäuerle Peter , Santos-Torres Julio , Böhm Claudia , Schmitz Dietmar , Geiger Jörg RP , Dugladze Tamar , Gloveli Tengis
Published: May 2016

Gamma rhythms are known to contribute to the process of memory encoding. However, little is known about the underlying mechanisms at the molecular, cellular and network levels. Using local field potential recording in awake behaving mice and concomitant field potential and whole-cell recordings in slice preparations we found that gamma rhythms lead to activity-dependent modification of hippocampal networks, including alterations in sharp wave-ripple complexes. Network plasticity, expressed as long-lasting increases in sharp wave-associated synaptic currents, exhibits enhanced excitatory synaptic strength in pyramidal cells that is induced postsynaptically and depends on metabotropic glutamate receptor-5 activation. In sharp contrast, alteration of inhibitory synaptic strength is independent of postsynaptic activation and less pronounced. Further, we found a cell type-specific, directionally biased synaptic plasticity of two major types of GABAergic cells, parvalbumin- and cholecystokinin-expressing interneurons. Thus, we propose that gamma frequency oscillations represent a network state that introduces long-lasting synaptic plasticity in a cell-specific manner.
Multisensory integration in the developing tectum is constrained by the balance of excitation and inhibition
Authors: Felch Daniel L , Khakhalin Arseny S , Aizenman Carlos D
Published: May 2016

Multisensory integration (MSI) is the process that allows the brain to bind together spatiotemporally congruent inputs from different sensory modalities to produce single salient representations. While the phenomenology of MSI in vertebrate brains is well described, relatively little is known about cellular and synaptic mechanisms underlying this phenomenon. Here we use an isolated brain preparation to describe cellular mechanisms underlying development of MSI between visual and mechanosensory inputs in the optic tectum of Xenopus tadpoles. We find MSI is highly dependent on the temporal interval between crossmodal stimulus pairs. Over a key developmental period, the temporal window for MSI significantly narrows and is selectively tuned to specific interstimulus intervals. These changes in MSI correlate with developmental increases in evoked synaptic inhibition, and inhibitory blockade reverses observed developmental changes in MSI. We propose a model in which development of recurrent inhibition mediates development of temporal aspects of MSI in the tectum.
An enigmatic aquatic snake from the Cenomanian of Northern South America
Authors: Albino Adriana , Carrillo-Briceño Jorge D. , Neenan James M.
Published: May 2016

We report the first record of a snake from the Cretaceous of northern South America. The remains come from the La Luna Formation (La Aguada Member, Cenomanian of Venezuela) and consist of several vertebrae, which belong to the precloacal region of the vertebral column. Comparisons to extant and extinct snakes show that the remains represent a new taxon,Lunaophis aquaticusgen. et sp nov. An aquatic mode of life is supported by the ventral position of the ribs, indicating a laterally compressed body. The systematic relationships of this new taxon are difficult to determine due to the scarcity of fossil material; it is, however, a representative of an early lineage of snakes that exploited tropical marine pelagic environments, as reflected by the depositional conditions of the La Aguada Member.Lunaophisis also the first aquatic snake from the Cenomanian found outside of the African and European Tethyan and Boreal Zones.
Motion of the MMS spacecraft relative to the magnetic reconnection structure observed on 16 October 2015 at 1307 UT
Authors: Denton R. E. , Sonnerup B. U. Ö. , Hasegawa H. , Phan T. D. , Russell C. T. , Strangeway R. J. , Giles B. L. , Gershman D. , Torbert R. B.
Published: May 2016

We analyze a magnetopause crossing by the Magnetospheric Multiscale (MMS) spacecraft at 1307 UT on 16 October 2016 that showed features of electron‐scale reconnection. For this event, we find orthonormal LMN coordinates from the magnetic field, with N and L varying respectively along the maximum gradient and maximum variance directions. We find the motion along N from the Spatio‐Temporal Difference analysis and motion along L from measured particle velocities. We locate the position of the magnetic X point, finding that MMS‐4 passed within about 1.4 km from the X point and that MMS‐3 and MMS‐2 passed within about 1.7 km and 2.4 km, respectively, from the position of maximum out of plane current.
Compact resonator on leather for nonradiative inductive power transfer and far‐field data links
Authors: Monti G. , Corchia L. , De Benedetto E. , Tarricone L.
Published: May 2016

In this paper, a wearable resonator suitable to be used for both power and data transmission is presented. The basic element is a complementary split ring resonator that has been optimized to operate both as a dipole‐like antenna at 2.45 GHz and as the receiver of a resonant energy link operating at 915 MHz when coupled with an identical external resonator connected to a power source. Experimental data referring to a prototype fabricated by using a conductive adhesive fabric on a leather substrate are reported and discussed. With regard to the wireless resonant energy link (WREL), it is demonstrated that at 915 MHz, the RF‐to‐RF power transfer efficiency of the link is approximately 78.1%. As for the performance obtained when the resonator is used as an antenna, a gain of approximately −0.43 dB was obtained. Additionally, the performance of the proposed link when connected to a Power Management Unit (PMU) that converts the radio frequency (RF) energy received by the wearable resonator into DC energy that can be directly used for recharging a thin‐film battery was also investigated. Experimental tests were performed in order to evaluate both the total efficiency of the wireless charger (i.e., the WREL link connected to the PMU) and the time necessary to recharge a THINERGY MEC201 battery. The obtained results demonstrate the feasibility of using the proposed WREL for implementing a battery charger; in particular, by providing an input power higher than 8 dBm, the time necessary to recharge the considered thin‐film battery is shorter than 38 min.
Bone‐Inspired Materials by Design: Toughness Amplification Observed Using 3D Printing and Testing
Authors: Libonati Flavia , Gu Grace X. , Qin Zhao , Vergani Laura , Buehler Markus J.
Published: May 2016

Inspired by the fact that nature provides multifunctional composites by using universal building blocks, the authors design and test synthetic composites with a pattern inspired by the microstructure of cortical bone. Using a high‐resolution multimaterial 3D printer, the authors are able to manufacture samples and investigate their fracture behavior in mechanical tests. The authors’ results demonstrate that the bone‐inspired design is critical for toughness amplification and balance with material strength. The failure modes of the authors’ synthetic composites show similarities with the cortical bone, like crack deflection and branching, constrained microcracking, and fibril bridging. The authors’ results confirm that our design is eligible to reproduce the fracture and toughening mechanism of bone.
Supramolecular Polymeric Fluorescent Nanoparticles Based on Quadruple Hydrogen Bonds
Authors: Peng Hui‐Qing , Sun Cai‐Li , Niu Li‐Ya , Chen Yu‐Zhe , Wu Li‐Zhu , Tung Chen‐Ho , Yang Qing‐Zheng
Published: May 2016

A facile approach for the preparation of supramolecular polymer‐based fluorescent nanoparticles (FNPs) is reported. FNPs with homogeneous shape and size distribution are fabricated from low‐molecular‐weight molecules, and thus, different compositional constituents can be efficiently incorporated via copolymerization. The emission color of the FNPs covers a wide region from blue to near infrared and can be easily tuned using efficient excitation energy transfer. The photoswitchable fluorescent nanoparticles with high on–off fluorescence contrast are also simply prepared by copolymerization of monomers containing a fluorophore and a photochromic unit. Our FNPs are successfully applied in living cell imaging and as fluorescent inks.
Tough Hydrogels with Programmable and Complex Shape Deformations by Ion Dip‐Dyeing and Transfer Printing
Authors: Peng Xin , Li Yang , Zhang Qin , Shang Cong , Bai Qing‐Wen , Wang Huiliang
Published: May 2016

Stimuli‐responsive hydrogels with high mechanical strength, programmable deformation, and simple preparation are essential for their practical applications. Here the preparation of tough hydrogels with programmable and complex shape deformations is reported. Janus hydrogels with different compositions and hydrophilic natures on the two surfaces are first prepared, and they exhibit reversible bending/unbending upon swelling/deswelling processes. More impressively, the deformation rate and extent of the hydrogels can further be easily controlled through an extremely simple and versatile ion dip‐dyeing (IDD) and/or ion transfer printing (ITP) method. By selectively printing proper patterns on 1D gel strips, 2D gel sheets and 3D gel structures, the transformations from 1D to 2D, 2D to 3D, and 3D to more complicated 3D shapes can be achieved after swelling the ion‐patterned hydrogels in water. The swelling‐deformable Janus and ion‐patterned hydrogels with high mechanical strengths and programmable deformations can find many practical applications, such as soft machines.
Large‐Scale Synthesis of Highly Luminescent Perovskite‐Related CsPb2Br5 Nanoplatelets and Their Fast Anion Exchange
Authors: Wang Kun‐Hua , Wu Liang , Li Lei , Yao Hong‐Bin , Qian Hai‐Sheng , Yu Shu‐Hong
Published: May 2016

All‐inorganic cesium lead‐halide perovskite nanocrystals have emerged as attractive optoelectronic nanomaterials owing to their stabilities and highly efficient photoluminescence. Herein we report a new type of highly luminescent perovskite‐related CsPb2Br5 nanoplatelets synthesized by a facile precipitation reaction. The layered crystal structure of CsPb2Br5 promoted an anisotropic two‐dimensional (2D) crystal growth during the precipitation process, thus enabling the large‐scale synthesis of CsPb2Br5 nanoplatelets. Fast anion exchange has also been demonstrated in as‐synthesized CsPb2Br5 nanoplatelets to extend their photoluminescence spectra to the entire visible spectral region. The large‐scale synthesis and optical tunability of CsPb2Br5 nanoplatelets will be advantageous in future applications of optoelectronic devices.
On a distribution‐free discriminant analysis
Authors: Gupta A. K. , Kim B. K.
Published: May 2016

In this paper a distribution‐free classification procedure is studied when it is assumed that the characteristic in one population is stochastically larger than in the other. The procedure utilizes the kernel type density estimators. An upper bound for the failure rate is also derived and the classification rule is shown to be consistent.
Genome‐scale RNA interference screen identifies antizyme 1 (OAZ1) as a target for improvement of recombinant protein production in mammalian cells
Authors: Xiao Su , Chen Yu Chi , Buehler Eugen , Mandal Swati , Mandal Ajeet , Betenbaugh Michael , Park Myung Hee , Martin Scott , Shiloach Joseph
Published: May 2016

For the purpose of improving recombinant protein production from mammalian cells, an unbiased, high‐throughput whole‐genome RNA interference screen was conducted using human embryonic kidney 293 (HEK 293) cells expressing firefly luciferase. A 21,585 human genes were individually silenced with three different siRNAs for each gene. The screen identified 56 genes that led to the greatest improvement in luciferase expression. These genes were found to be included in several pathways involved in spliceosome formation and mRNA processing, transcription, metabolic processes, transport, and protein folding. The 10 genes that most enhanced protein expression when downregulated, were further confirmed by measuring the effect of their silencing on the expression of three additional recombinant proteins. Among the confirmed genes, OAZ1—the gene encoding the ornithine decarboxylase antizyme1—was selected for detailed investigation, since its silencing improved the reporter protein production without affecting cell viability. Silencing OAZ1 caused an increase of the ornithine decarboxylase enzyme and the cellular levels of putrescine and spermidine; an indication that increased cellular polyamines enhances luciferase expression without affecting its transcription. The study shows that OAZ1 is a novel target for improving expression of recombinant proteins. The genome‐scale screening performed in this work can establish the foundation for targeted design of an efficient mammalian cell platform for various biotechnological applications. Biotechnol. Bioeng. 2016;113: 2403–2415. © 2016 Wiley Periodicals, Inc.
Preliminary Report of Clinical Outcomes After Single Crossover Bioresorbable Scaffold Implantation Without Routine Side Branch Strut Dilation
Authors: Tanaka Akihito , Jabbour Richard J. , Kawamoto Hiroyoshi , Mangieri Antonio , Pagnesi Matteo , Montalto Claudio , Chieffo Alaide , Carlino Mauro , Montorfano Matteo , Latib Azeem , Colombo Antonio
Published: May 2016

Objectives

The objective of this study was to investigate clinical outcomes following single crossover bioresorbable scaffold (BRS) implantation without routine side branch (SB) strut dilation.

Background

It is unknown whether SB strut dilation is routinely required after single crossover BRS implantation if there is no compromise of the jailed SB.

Methods

Among 187 bifurcation lesions treated with Absorb BRS, 115 lesions (101 patients) were treated with single crossover BRS implantation. Strut dilation toward SB was considered only when SB was compromised (SB TIMI flow < 3 or SB ostium > 75%) after main branch (MB) BRS implantation. Clinical outcomes including cardiac death, follow‐up myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), and definite scaffold thrombosis (ST) were investigated.

Results

The majority of target lesions were in the left anterior descending artery (73.0%) and the rate of true bifurcation lesions was 42.6%. SB strut dilation was performed in only 20% of lesions (n = 23), and intravascular imaging was used in most cases (90.4%). The rates of TLR per lesion at 1‐year was 3.1% in MB, and 0% in SB. In all patients, the cumulative rate of cardiac death was 1.1% at 1‐year, follow‐up MI 2.2%, TVR 3.5%, and definite ST 1.0%.

Conclusion

Clinical outcomes were acceptable in bifurcation lesions treated with single crossover BRS implantation without routine SB strut dilation. © 2016 Wiley Periodicals, Inc.
Heterogeneous Hydrogenation of Esters under Mild Conditions using Solid‐Supported Phosphorus–Ruthenium Catalysts
Authors: Heutz Frank J. L. , Erken Christina , Aguila Mae Joanne B. , Lefort Laurent , Kamer Paul C. J.
Published: May 2016

The catalytic reduction of esters by using H2 is a sustainable alternative to the use of classic stoichiometric reagents. Nowadays, a wide range of highly efficient homogeneous catalysts are known, but these suffer from poor catalyst recoverability. Therefore, most industrial applications are based on heterogeneous catalysts, but these processes are generally operated under harsh conditions (>200 °C, >10.0 MPa). Herein, we describe the first catalytic system that combines the activity of a homogeneous catalyst with the recoverability of a heterogeneous catalyst. The presented system is capable of hydrogenating esters under very mild conditions (25 °C, 5.0 MPa) and can easily be recovered. The catalyst is based on phosphorus ligands covalently attached to a polymeric support and is readily obtained by a facile solid‐phase synthetic protocol in high yields with minimal workup.
Ensemble Correntropy‐Based Mooney Viscosity Prediction Model for an Industrial Rubber Mixing Process
Authors: Liu Yi , Fan Yu , Zhou Lichun , Jin Fujiang , Gao Zengliang
Published: May 2016

The development of accurate soft sensors for online prediction of Mooney viscosities in industrial rubber mixing processes is a difficult task because the modeling dataset often contains various outliers. A correntropy kernel learning (CKL) method for robust soft sensor modeling of nonlinear industrial processes with outlier samples is proposed. Simultaneously, the candidate outliers can be identified once the CKL‐based soft sensor model is built. An index for describing the uncertainty of the CKL model is designed. Furthermore, to obtain more robust and accurate predictions, an ensemble CKL (ECKL) method is formulated by introducing the simple bagging strategy. Consequently, by detecting the outliers in a sequential manner, the database becomes more reliable for long‐term use. The application results for the industrial rubber mixing process demonstrate the superiority of ECKL in terms of better prediction performance.
Kinetics of Isophorone Synthesis via Self‐Condensation of Supercritical Acetone
Authors: Mei Jun , Chen Zhirong , Yuan Shenfeng , Mao Jianyong , Li Haoran , Yin Hong
Published: May 2016

A kinetic study on isophorone synthesis via self‐condensation of supercritical acetone catalyzed by aqueous KOH in a tubular flow reactor was conducted. The intention was to improve the isophorone selectivity, with the main approach to reduce the by‐products higher‐boiling than isophorone. A higher isophorone selectivity was obtained with increased reaction temperature. The structures of main products were determined by gas chromatography‐mass spectrometry and nuclear magnetic resonance analysis. The key reaction pathways and a corresponding kinetic model were proposed. The fitted apparent activation energies indicated the reason of isophorone selectivity improvement in that high temperature favors reversion of reversible by‐products.
ChemInform Abstract: Isomerization of Dihydropentalenes and Reaction with Tetracyanoethylene.
Authors: PAULI A. , KOLSHORN H. , MEIER H.
Published: May 2016

The six isomeric dihydropentalenes (I)‐(VI) are connected by various H‐shifts, which are investigated in gas phase pyrolyses at 700‐1200 °C. Thermodynamic control leads irreversibly from the equilibria between (I)‐(VI) to styrene (VIII) via 1‐vinylfulvene (VII).
ChemInform Abstract: Studies of the N‐Oxygenation of N‐(tert‐Alkyl)benzamidines in vitro.
Authors: CLEMENT B. , IMMEL M.
Published: May 2016

Benzonitrile (I) reacts with the amines (II) in the presence of aluminum trichloride, producing the benzamidines (III).
ChemInform Abstract: Reactions with Aziridines. Part 40. Nucleophilic Ring Opening of 2,2‐Dimethylaziridines by the Anions of Fluorene and Carbazole. Control of Regioselectivity by the Kind of Aziridine Activation.
Authors: ASSITHIANAKIS P. , ONISTSCHENKO A. , STAMM H.
Published: May 2016

Fluorene (Ia) and carbazole (Ib) are converted to the corresponding anions which react with the N‐benzoylaziridines (II), forming the 1,1‐dimethyl‐2‐acrylaminoethyl derivatives (III).
ChemInform Abstract: Stereocontrolled Route to 2,3,5‐Trisubstituted Tetrahydrofurans. Intermediates for the Total Synthesis of Polyether Antibiotics.
Authors: FRAUENRATH H. , RUNSINK J.
Published: May 2016

Double‐bond isomerization of the 4,7‐dihydro‐1,3‐dioxepins (III) gives the corresponding 4,5‐dihydro‐1,3‐dioxepins (IV).
ChemInform Abstract: Reaction of Mesoionic Thiazol‐4‐ones with Azodicarbonyl Dipolarophiles. Cleavage Modes of the Bi‐ and Tricyclic Adducts.
Authors: SHERADSKY T. , ITZHAK N.
Published: May 2016

The reaction of the mesoionic heterocycles (I) with (II) gives the adducts (III) which, on heating in benzene, undergo rearrangement to yield (IV).
ChemInform Abstract: A New Mode of Formation of the Phosphorus‐Phosphorus Bond: Synthesis and Crystal Structure Determination of 1,5‐Dichloro‐2,4‐dimethyl‐2,4‐diaza‐1,5‐diphospha‐1,5‐diphenylpentan‐3‐one and of 1,4‐Dimethyl‐2,3‐Diphenyl‐1,4,3,2‐diazadiphospholidin‐5‐one‐2‐oxide and Its Oxidation with Tetrachloroorthobenzoquinone.
Authors: BETTERMANN G. , SCHMUTZLER R. , POHL S. , THEWALT U.
Published: May 2016

The structure of the title compounds (III) and (V) is established by X‐ray analysis (space groups P1 and P21/n with Z=2 and Z = 8, respectively).
ChemInform Abstract: Preparation and Physical Properties of Trinuclear Oxo‐Centered Manganese Complexes of the General Formulation (Mn3O(O2CR)6L3)0,+ (R: Me or Ph; L: a Neutral Donor Group) and the Crystal Structures of (Mn3O(O2CMe)6(pyr)3)(pyr) and (Mn3O(O2CPh)6(pyr)2(H2O))·0,5 MeCN.
Authors: VINCENT J. B. , CHANG H.‐R. , FOLTING K. , HUFFMAN J. C. , CHRISTOU G. , HENDRICKSON D. N.
Published: May 2016

The reaction of a polymeric Mn(III) acetate, readily obtained from the oxidation of Mn(II) acetate‐tetrahydrate with Bu4NMnO4, with acetic acid or benzoic acid in the presence of an excess of neutral donor ligands leads to the high‐yield formation of the trinuclear oxo‐centered Mn complexes (I).
ChemInform Abstract: Synthesis and Structure of the Iron‐Selenium Cubane Cluster ((η5‐C5H5)4Fe4Se4)3+: The Fourth Member of the ((η5‐C5H5)4Fe4Se4)n Series (n = 0 to 4+).
Authors: OGINO H. , TOBITA H. , YANAGISAWA K. , SHIMOI M. , KABUTO C.
Published: May 2016

On the basis of the redox behavior of (II), prepared in quantitative yield by the reaction of (I) with 3/8 molar equiv. red selenium (II) as shown, the bulk electrolysis of (II) leads to the dication salt (III).
ChemInform Abstract: Deceptive Similarities in the Reactions of Fe+ and Co+ with Linear Nitriles in the Gas Phase.
Authors: LEBRILLA C. B. , DREWELLO T. , SCHWARZ H.
Published: May 2016

The gas‐phase reactions of Fe+ and Co+ with linear C‐4‐C‐12 nitriles are investigated.
ChemInform Abstract: Electrochemical and Spectroscopic Analyses of the Thermodynamics of the Reversible Dimerization of Cyanine Radical Dications.
Authors: LENHARD J. R. , PARTON R. L.
Published: May 2016

The results of thermodynamic and kinetic characterization of the reversible dimerization of radical dications formed by chemical (ferric chloride in MeOH/H2O) and/or electrochemical oxidation of a range of 15 thia‐ and quinodicarbocyanines (I)‐(VI) are given.
ChemInform Abstract: Syntheses of Liquid Crystalline Phthalocyanines.
Authors: HANACK M. , BECK A. , LEHMANN H.
Published: May 2016

The phthalocyanines (I) with long side‐chains are prepared by standard methods.
ChemInform Abstract: Hetero Diels‐Alder Reactions in Carbohydrate Chemistry: A New Strategy for Multichiral Arrays Synthesis.
Authors: CHAPLEUR Y. , EUVRARD M.‐N.
Published: May 2016

The dibenzylidene methyl pyranoside (I) is treated with butyllithium and then coupled with the aldehydes (II), yielding the carbinols (III) as a mixture of isomers.
ChemInform Abstract: Luminescence Properties of (Sr,Ca)‐hexaborate:Pb2+, Gd3+.
Authors: TEWS W. , BECKER P. , HERZOG G. , KUENZLER G. +
Published: May 2016

Under Hg‐low‐pressure excitation (Sr,Ca)O·3 B2O3:Pb2+, Gd3+ (prepared by solid state reaction of intimate mixtures of H3BO3, SrCO3, and/or CaCO3, PbCO3, and Gd2O3 at 700 °C) emits in the UV region (λem(Pb)Sr‐hexaborate = 303 nm; λem(Pb)Ca‐hexaborate = 284 nm; λem(Gd) = 311‐313nm).
ChemInform Abstract: Standard Potentials of the (MO2+ 2/MO+ 2) Systems for Uranium and Other Actinides.
Authors: RIGLET CH. , VITORGE P. , GRENTHE I.
Published: May 2016

The formal potentials of the UO22+/UO2+ couple have been determined in NaClO4 media of varying ionic strength and the data are interpreted by the Broensted‐Guggenheim‐Scatchard specific ionic interaction theory (SIT) yielding a standard potential/E ° of +0.089 V vs.
ChemInform Abstract: Improvement of Charge Transfer Kinetics at Transparent SnO2 Counterelectrodes by Means of a Radiolytic Grafting of Metallic Nanoaggregates.
Authors: BRUNEAUX J. , CACHET H. , FROMENT M. , AMBLARD J. , BELLONI J. , MOSTAFAVI M.
Published: May 2016

A new radiolytic process has been developed to graft metallic nanoaggregates on SnO2 transparent counter electrodes (tce) in order to improve their electrochemical behavior.
ChemInform Abstract: Synthesis of Lithium Dialuminate by Salt Imbibition.
Authors: POEPPELMEIER K. R. , HWU S.‐J.
Published: May 2016

LiAl2(OH)7·2 H2O (I), prepared by reaction of solid lithium hydroxide, polycrystalline bayerite, and water vapor at 20 °C appears to be identical with that prepared by precipitation from supersaturated aluminate solutions or by reaction of lithium salts with freshly precipitated aluminum hydroxide in aqueous solution (TGA, IR, XRD).
ChemInform Abstract: Polyvanadates of Rubidium and Cesium.
Authors: VOLKOV V. L. , ZAKHAROVA G. S. , IVAKIN A. A. , PESINA Z. M.
Published: May 2016

Solutions of rubidium and cesium peroxovanadates are prepared from V2O5, H2O2 and RbVO3 or CsVO3.
ChemInform Abstract: β‐Oxido‐Functionalized Organolithium Intermediates from Ketones: A Simple New Access.
Authors: BARLUENGA J. , FERNANDEZ‐SIMON J. L. , CONCELLON J. M. , YUS M.
Published: May 2016

The ketones (I) are coupled with chloromethyllithium (II) and then directly treated with lithium naphthalenide to yield the dilithium intermediates (III) which react with various electrophiles (IV), forming the hydroxy compounds (V).
ChemInform Abstract: Cycloaddition of the Trimethylenemethane‐Palladium Complex to Activated Six‐Membered and Medium‐Size Ring Enones.
Authors: CLEARY D. G. , PAQUETTE L. A.
Published: May 2016

The cyclohexenones (I) react with the acetoxymethylallylsilane (II) in the presence of a Pd(0) catalyst generated in situ to produce the methylenecyclopentanocyclohexanones (III).
ChemInform Abstract: The Photocycloaddition of Acetylacetone with Naphthols and Their Methyl Ethers.
Authors: CHOW Y. L. , BUONO‐CORE G. E. , LIU X.‐Y. , ITOH K. , QIAN P.
Published: May 2016

Photochemical reaction of the naphthols (Ia) and (Va) and their methyl ethers (Ib) and (Vb) with the enol form (II) of acetylacetone only takes place when (II) is excited by irradiation.
ChemInform Abstract: A Mild Neutral Reagent for the Oxidation of Alcohols to Carbonyl Compounds.
Authors: MOISEENKOV A. M. , CHESKIS B. A. , VESELOVSKII A. B. , VESELOVSKII V. V. , ROMANOVICH A. YU. , CHIZHOV O. S.
Published: May 2016

Trimethylsilyl chromate, the title reagent, is prepared in situ by heating hexamethylsiloxane and CrO3 to 60 °C. The novel reagent oxidizes primary alcohols as e.g. (I) and secondary alcohols as e.g. (III) under neutral and mild conditions.
ChemInform Abstract: Electron Transfer. Part 87. Autocatalysis in the Reductions of Vanadium(IV) and Molybdenum(VI) with Vitamin B12s (Cob(I)alamin).
Authors: PILLAI G. C. , BOSE R. N. , GOULD E. S.
Published: May 2016

Vitamin B12s reduces vanadium(IV) and molybdenum(VI) in aqueous solution.
ChemInform Abstract: 2‐(Chloromethyl)‐3,5‐dioxahex‐1‐ene. An Effective Acetonylating Reagent.
Authors: GU X.‐P. , NISHIDA N. , IKEDA I. , OKAHARA M.
Published: May 2016

The reagent (II) mentioned in the title is prepared from the dichloro acetal (I) under solid‐liquid phase‐transfer conditions.
ChemInform Abstract: Reaction of Acetylenic and Vinylic Organolithium Reagents with Triethoxycarbenium Tetrafluoroborate: Preparation of α‐Acetylenic and α‐Ethylenic Triethyl Orthocarboxylates.
Authors: PICOTIN G. , MIGINIAC P.
Published: May 2016

The reaction mentioned in the title yields selectively the triethyl orthocarboxylates (III).
ChemInform Abstract: Hydroformylation of Formaldehyde to give Glycolaldehyde with Halide‐ Promoted Rh4(CO)12.
Authors: MARCHIONNA M. , LONGONI G.
Published: May 2016

Hydroformylation of paraformaldehyde (I) or 37% aqueous formaldehyde with syngas (II) in the presence of Rh4(CO)12 and bulky onium halides yields glycolaldehyde (III), together with methanol (IV) and methyl formate (V).
ChemInform Abstract: Action of Dinitrogen Tetroxide on the 5‐Hydroxy‐3,5‐dimethyl‐4‐oximido‐2‐isoxazoline System.
Authors: FRUTTERO R. , FERRAROTTI B. , GASCO A.
Published: May 2016

The isoxazoline (I) reacts with dinitrogen tetroxide to form the O‐acetyloxime (II).
ChemInform Abstract: Synthesis and Reactions of Regioisomeric Epoxides of the Tricyclo(4.2.2.02,5)decane Series.
Authors: ZEFIROV N. S. , KIRIN V. N. , YUR'EVA N. M. , KOZ'MIN A. S.
Published: May 2016

The oxidation of the tricyclotriene (I) with peracids or with MoO5·2 HMPA complex yields the exo‐3,4‐epoxide (II), the endo‐7,8‐epoxide (III) and/or the exo‐3,4‐endo‐7,8‐diepoxide (IV) or mixtures of these epoxides.
ChemInform Abstract: Relative Intramolecular Reactivity of a π Double Bond and the 10π Annulene Moiety Toward Sulfur Trioxide: Sulfonation of 11‐Methylene‐1,6‐ methano(10)annulene, 12,12‐Dimethyl‐11‐methylene‐1,6‐methano(10)annulene, and 11‐Oxo‐1,6‐methano(10)annulene with SO3.
Authors: CERFONTAIN H. , KOEBERG‐TELDER A. , LAMBRECHTS H. J. A. , LINDNER W. , ZHANG S.‐Z. , VOGEL E.
Published: May 2016

The annulenes (I) are allowed to react with SO3 in an NMR tube.
ChemInform Abstract: Lewis Acid Promoter Reaction of Pentacyclo(5.4.0.02,6.03,10.05,9)undecane‐8,11‐dione with Ethyl Diazoacetate: A Synthetic Entry into the Pentacyclo(6.5.0.04,12.05,10.09,13)tridecane Ring System.
Authors: MARCHAND A. P. , ARNEY B. E. JUN. , GILARDI R. , FLIPPEN‐ANDERSON J. L.
Published: May 2016

The pentacyclic dione (I) reacts with the diazoacetate (II) in the presence of BF3 etherate, yielding the dihydroxydicarboxylate (III).
ChemInform Abstract: Chemistry of Organolanthanoids. Lanthanoid‐Mediated C‐C Bond Formation and Cleavage and C‐C Double Bond Reduction.
Authors: HOU Z. , FUJIWARA Y. , JINTOKU T. , MINE N. , YOKOO K. , TANIGUCHI H.
Published: May 2016

The α,β‐unsaturated carbonyl compounds (I) react regioselectively with equivalent amounts of the organolanthanoids (II) to form the 1,2‐addition products (III).
ChemInform Abstract: Oxidation of Sulfides to Sulfoxides by 1‐Acetyl‐v‐triazolo(4,5‐b)pyridine/Hydrogen Peroxide System.
Authors: TORRINI I. , PARADISI M. P. , ZECCHINI G. P. , AGROSI F.
Published: May 2016

The sulfides (I) are converted to the sulfoxides (II) using the triazolopyridine/hydrogen peroxide reagent system mentioned in the title.
ChemInform Abstract: Reaction of Phenol with Oct‐1‐yne in the Presence of Aluminium Phenolate.
Authors: KOZLIKOVSKII YA. B. , KOSHCHII V. A. , BUTOV S. A.
Published: May 2016

The reaction between phenol (I) and oct‐1‐yne (II) in the presence of aluminum phenolate, molar ratio 3:1:0.5, at 130 °C yields a separable mixture of the desired 2,2‐di(hydroxyphenyl)octanes (III) and (IV) along with the chromane (V) and the chromene (VI).
ChemInform Abstract: Steric Factors in Amide‐Directed Metalations of N,N‐Dialkyl‐6‐methoxynaphthalene‐2‐carboxamides: Synthesis of a Sterically Perturbed Acylnaphthol.
Authors: BINDAL R. D. , KATZENELLENBOGEN J. A.
Published: May 2016

The carboxamides (III) are prepared from the methoxynaphthalenecarboxylic acid (I) by treatment of the acid chloride with the secondary amines (II).
ChemInform Abstract: Convenient Synthesis of 4‐Nitrotetralones by Selective Side‐Chain Nitration of Methyl‐Substituted Acryloylbenzenes, Followed by Intramolecular Michael Reaction.
Authors: KEUMI T. , INAGAKI T. , NAKAYAMA N. , MORITA T. , KITAJIMA H.
Published: May 2016

Nitration of the polymethyl‐substituted acryloylbenzenes (I) yields the 2‐nitromethyl derivatives (II) which undergo an intramolecular Michael addition reaction on treatment with a base to give the 4‐nitrotetralones (III).
ChemInform Abstract: Synthesis of 1,3‐Disubstituted 4‐Isonitrosopyrazol‐5‐ones from N‐Alkyl(Arylalkyl)‐N‐nitrosohydrazines.
Authors: LANOVAYA G. A. , MASHIKHINA A. S. , FEDOROVA V. A. , MIKHEEVA V. P. , BONDARENKO O. D.
Published: May 2016

The reaction between the N‐nitrosohydrazines (I) and ethyl acetoacetate (II) is studied for the first time.
ChemInform Abstract: Reaction of Diazoalkanes on the Activated C(4)‐C(5) Isoxazole Double Bond: A New Entry of the 2‐Oxa‐3‐azabicyclo(3.1.0)hex‐3‐ene Ring System.
Authors: NESI R. , GIOMI D. , QUARTARA L. , BRACCI S. , PAPALEO S.
Published: May 2016

Diazomethane (IIa) and 2‐diazopropane (IIb) undergo cycloaddition reaction with the isoxazole derivative (I) to yield the unstable adducts (III) which release nitrogen to give the bicyclic derivatives (IV).
ChemInform Abstract: Synthesis and Reactivity of Fluorinated Enynes.
Authors: TELLIER F. , SAUVETRE R. , NORMANT J. F.
Published: May 2016

Palladium‐catalyzed cross‐coupling reaction of the vinylic iodides (I) with the acetylides (II) yields the fluoroenynes (III).
ChemInform Abstract: Synthesis of Substituted Furobenzopyrones.
Authors: HISHMAT O. H. , ABD EL RAHMAN A. H. , EL DIWANI H. I. , ABU BAKR SH. M.
Published: May 2016

Title compounds of type (V) and (VIII) are synthesized as shown.
ChemInform Abstract: Synthesis and Spectrophotometric Characteristics of Substituted 4‐Chromonylmethylenepyrazol‐5‐ones.
Authors: POLYAKOV V. K. , BABICH YU. P. , SHEVTSOVA R. G. , TRUSEVICH N. D. , LAVRUSHIN V. F.
Published: May 2016

The pyrazolone (II) is coupled with the chromonealdehydes (I) to give the chromonylmethylenepyrazolones (III).
ChemInform Abstract: Nickel‐, Palladium‐, and Platinum‐Catalyzed Reactions of Perfluoro‐ and Polyfluoroalkyl Iodides with Tertiary Amines.
Authors: HUANG Y.‐Z. , ZHOU Q.‐L.
Published: May 2016

The enamines (III) are prepared by reaction of the iodide (Ib) with the tertiary amines (II) in the presence of triphenylphosphine metal catalysts.
ChemInform Abstract: Cycloaracylation of Enamines. Part 2. Synthesis of 1‐Amino‐4‐quinolone‐3‐carboxylic Acids.
Authors: GROHE K. , HEITZER H.
Published: May 2016

The aminoquinolonecarboxylic acids (Va)‐(Vd) are prepared from the acrylic esters (I).