bluuebunny/crossref_metadata_2025 huggingface dataset:
VOC investigation factors in the rainforest
Authors: müntz robert
Published: June 2023

So far, numerous VOC research studies have been undertaken on orchids to gain a deeper understanding of their propagation mechanisms. Analyses can be carried out in the laboratory under ideal conditions; external influences of the ambient atmosphere can thus be excluded.
For extensive field studies on the orchid population of an area, samples must be taken directly at the specimen site. As a result, VOCs in the ambient air are considered a matrix when evaluating the results.
VOCs in the ambient air must be considered when evaluating the results; a display of the VOCs in a matrix is usually used for this purpose.
Plant components, in particular higher molecular weight plant waxes (C 28 - C 35), are degraded by microorganisms and UV radiation and are found in the forest air as VOCs (alkanes, aldehydes, and ketones).
By developing a “scentor” (scent collector) with a closed system, both the sensitivity of the detection limit and the exclusion of the surrounding scents can be achieved.
Most of the VOCs found are monoterpenes, followed by sesquiterpenes and to a lesser extent terpenoids, i.e., terpene structures with functional groups. The ubiquitous components of the air (alkanes, aldehydes, and ketones) occurring in outdoor measurements originate from the microbial degradation of higher molecular weight plant waxes (C 28 - C 35) and were taken into account in the evaluation.
Effect of Saline-alkali Stress on Seed Germination of the Halophyte Halostachys caspica
Authors: Zhang Rui , zhang Huizhen , wang lai , Zeng Youling
Published: June 2023

The process of soil salinization and the preponderance of saline water sources all over the world represent one of the most harmful abiotic stresses to plant growth. In nature, soil salt and alkali coexist, and the interaction of salt and alkali is an important feature of saline-alkali stress. Halostachys caspica is a salt-tolerant halophyte belonging to Amaranthaceae and widely distributed in arid and saline-alkali areas in Xinjiang, Northwest China. This paper studied the response of the germination of the desert halophyte Halostachys caspica to different types of salt stress, aiming to provide a theoretical basis for development and utilization of halophytes growing in saline-alkali soils. The results showed that the seed germination of Halostachys caspica was not significantly inhibited when the salt concentration was low (≤ 200 mmol/L), but with the increase of salt concentration, the germination rate of seeds dropped sharply, and the recovery germination rate at high concentration was higher than that at low concentration, when salt was removed. Step-by-step regression analysis showed that at the same concentration, the alkaline salt inhibited seed germination more severely than the neutral salts; the inhibitory effect of the mixed salt and mixed alkali on seed germination is heavier than that of the mono-salt and mono-alkali; under mixed salt alkali stress, the higher the alkaline salt content, the higher the degree of inhibition on seed germination; indicating that alkaline salt play a major role in mixed saline-alkali stress.
Driving gut microbiota enterotypes through host genetics
Authors: Rogel-Gaillard Claire , Larzul Catherine , Estellé Jordi , Borey Marion , Blanc Fany , Lemonnier Gaëtan , Jardet Deborah , Lecardonnel Jérôme , Billon Yvon , Thiam Mamadou-Gabou , Oñate Florian Plaza , Quinquis Benoit , Galleron Nathalie
Published: June 2023

Population stratification based on interindividual variability in gut microbiota composition revealed the existence of several configurations named enterotypes. Enterotypes are often associated with environmental factors whereas the potential impact of host genetics is debated. To explore the genetic determinism of host-microbiota interactions, we established two divergent pig lines with gut microbiota selected for genera pairs specifying two enterotypes (Prevotella and Mitsuokella, or Ruminococcusand Treponema). Per line, relative abundances of directly and indirectly selected genera increased, demonstrating that host genetics influences gut microbiota composition and enterotype prevalence over generations. Metagenomics illustrated different functional potentials between enterotypes and their effects on animal growth. Our work paves the way for a holistic use of host genetics, microbiota diversity and enterotype functionalities in understanding holobiont shaping and adaptation.
GenoBaits®WheatplusEE: a targeted capture sequencing panel for quick and accurate identification of wheat-Thinopyrum derivatives
Authors: Deng Pingchuan , Du Xin , Wang Yanzhen , Yang Xiaoying , Cheng Xiaofang , Huang Chenxi , Li Tingting , Li Tingdong , Chen Chunhuan , Zhao Jixin , Wang Changyou , Liu Xinlun , Tian Zengrong , Ji Wanquan
Published: June 2023

Thinopyrum species are an important source for new genetic variation for wheat improvement because they carry many agronomically important traits, such as abiotic/biotic resistances. Accurate identification of exogenous chromosome(s) or chromosome segments or genes is very important after alien genetic material has been successfully introduced into wheat, but remains challenging. Here, we report the development of a high-resolution wheat-Thinopyrum elongatum array, named GenoBaits®WheatplusEE, to trace alien genetic information through genotyping with a target sequencing system and a liquid chip. A total of 90000 capture probes derived from two species were integrated into one chip, including 10000 and 80000 within wheat and Th. elongatum, respectively. The capture probes were designed to be preferentially located in genes and evenly distributed across the genome, supporting the development of a roadmap guiding each alien genes. The array was applied to high-throughput identification of the alien chromosomes or segments in Thinopyrum and distantly related species, as well as derivatives. Our results validated that the GenoBaits®WheatplusEE array could direct identification of the breakpoint for the alien segment, the alien chromosome copy number, and the wheat chromosome variation by target sequencing the sample only once. Additionally, we can efficiently and cost-effectively genotype, supporting the exploration of subgenome composition, phylogenetic relationships, and important gene (e.g., Fhb7 gene) polymorphisms among Thinopyrum species and derivates. We expect GenoBaits®WheatplusEE to become a popular tool or model that empowers future exploration of the wild germplasm for wheat improvement.
GHP-MOFassemble: Diffusion modeling, high throughput screening, and molecular dynamics for rational discovery of novel metal-organic frameworks for carbon capture at scale
Authors: Huerta Eliu , Park Hyun , Yan Xiaoli , Zhu Ruijie , Chaudhuri Santanu , Cooper Donald , Foster Ian , Tajkhorshid Emad
Published: June 2023

We introduce GHP-MOFassemble, a Generative
artificial intelligence (AI), High Performance framework to accelerate the
rational discovery of metal-organic frameworks
(MOFs) with high CO2 capacity and synthesizable linkers. We combine a diffusion model, a class of generative AI, to generate
novel linkers that are assembled with one of three
pre-selected nodes into MOFs in a primitive cubic (pcu) topology. The CO2 capacities of these AI-generated MOFs are predicted using a modified version
of the crystal graph convolutional neural network model.
We then use the LAMMPS code to perform molecular
dynamics simulations to identify AI-generated MOF structures that converge to stable structures, and maintain their
porous properties throughout the simulations.
Among 120,000 pcu MOF candidates generated by GHP-MOFassemble, with three distinct metal
nodes (Cu paddlewheel, Zn paddlewheel, Zn tetramer), a total of 102 structures completed molecular dynamics simulations at 1bar with predicted CO2
capacity higher than 2mmol/g at 0.1 bar, which corresponds to the top 5% of hMOF in the hypothetical MOF (hMOF) dataset in the MOFX-DB database. Among these candidates, 18 have change in density lower than 1% during molecular dynamics simulations, indicating their stability. The
top five GHP-MOFassemble's MOFs have CO2 capacities higher than 96.9% of hMOF structures.
Beneficiaries’ Satisfaction with Community-Based Health Insurance Services and Associated Factors in Ethiopia: A Systematic Review and Meta-Analysis
Authors: Bayked Ewunetie Mekashaw , Toleha Husien Nurahmed , Zewdie Segenet , Mekonen Asnakew Molla , Workneh Birhanu Demeke , Kahissay Mesfin Haile
Published: June 2023

Background
The viability of community-based health insurance programs depends on beneficiary satisfaction, and healthcare systems evaluate performance through patient reports and ratings to ensure effectiveness and service quality. To our knowledge, Ethiopia lacks national pooled data on the satisfaction of community-based health insurance beneficiaries and related factors; this review aims to address that gap.
Methods
Database searches on Scopus, Hinari, PubMed, Google Scholar, and Semantic Scholar were conducted on September 1st, 2022. Thirteen studies were chosen for review from the search results. Checklists from the Joan Briggs Institute were used to evaluate the risk of bias for the included studies. The data were extracted using a 2019 Microsoft Excel spreadsheet and analyzed using RevMan-5 software and STATA 17. The odds ratios at p-values less than 0.05 with a 95% confidence interval were used to evaluate the effect estimates.
Results
The pooled satisfaction of beneficiaries with community-based health insurance was found to be 66.0% (95% CI = 0.57–0.76) and was found to be influenced by socio-demographic, health service-related, the scheme’s related factors, and the beneficiaries' knowledge of it. The beneficiary satisfaction levels were highest in the Amhara region, at 69.0% (95% CI = 0.59–0.79), followed by SNNPR at 67.0% (95% CI = 0.40–0.94), Oromia at 63.0% (95% CI = 0.58–0.68), and Addis Ababa at 53.0% (95% CI = 0.45–0.62).
Conclusion
Even though there was a moderate level of satisfaction, there are indications that the quality of health services and the coverage of the entire population lag behind, necessitating greater efforts to achieve universal health coverage.
Parameter Optimization of the MQL Nozzle by the Computational Fluid Dynamics
Authors: Yan Lan , Luo Kunhui , Jiang Tao , Xie Hong , Li Yousheng , Xiang Zhiyang , Jiang Feng
Published: June 2023

Minimum quantity lubrication (MQL) has achieved a good effect in precision machining. The geometric parameter of the nozzle has an important effect on the performance of MQL. In order to improve and optimize the performance of MQL, the orthogonal experimental method was adopted in this paper, and ANSYS Fluent software was used to carry out the computational fluid dynamics (CFD) simulation and the simulation data were statistically analyzed. The effects of six influencing factors (i.e. width of gas-phase narrow flow region, taper, output tube length, length of gas-phase narrow flow region, output aperture and pressure) on the performance of MQL were studied. The results showed that the primary and secondary order of the six influencing factors was different under different evaluation criteria. The most important parameter affecting the composite index was the absolute gas velocity at 0.1m away from the outlet. The optimal combination of the geometric parameters of the nozzle was output aperture of 2 mm, taper of 40 degrees, length of gas-phase narrow flow region of 1.5 mm, width of gas-phase narrow flow region of 0.3 mm, output tube length of 15.5 mm, and pressure of 5 bar.
Office Transport Services: The Service Quality Based on Users' Perceptions and Expectations
Authors: Amarasingha Niranga , Wimalasena D.C.V. Sulaksha
Published: June 2023

As the population grows, so does the need for travel. With rising demand, public transportation providers are finding it difficult to meet the demand. As a result, alternative transportation services such as office transport are becoming widespread in Sri Lanka. This study aims to determine the service quality of office transport services based on user perceptions and expectations of the service. Recently there is only one study carried out in Sri Lanka focusing on office transport services. A questionnaire survey was conducted to collect data on passenger perceptions and expectations. This questionnaire survey is done within Colombo District, Sri Lanka to assess the Office transport services. Respondents were asked to rate certain qualitative characteristics of the office transport service based on their perceptions and minimum expectations of the service. In this study, Factor analysis and Structural Equation Modeling (SEM) were used to analyse the data collected through questionnaire survey. It was identified that there are three primary factors affecting the service quality of office transport services which are vehicle, safety and timely performance. Using the final SEM model, it was identified that vehicle is the most affected factor for the service quality of the office transport services. Based on the findings of this study recommendations have been made to improve the service quality of the office transport services.
Spam Detection using Reference Text: A Preliminary Study for Spam Ground Truth Generation
Authors: Tarafdar Arunabha , Halder Chayan , Dash Dinesh
Published: June 2023

Spam detection is a large area of study that has been approached from many different angles. Spam has been a threat to the normal operation of the internet since the late 1990s and most recently. Today, spam is not just found in emails; it also affects several other platforms, including social media and chat web platforms. In recent years, there have been significant changes in both the variety and meaning of spam. We are throwing light on the topic of word spam in digital photographs distributed through an online chat platform in this paper. In this article, we’ll talk about spam texts as well as how to spot them.
Benzothiazole-Derived Covalent Organic Framework for Multimedia Iodine Uptake
Authors: Jaryal Ritika , Khullar Sadhika , Kumar Rakesh
Published: June 2023

Nuclear energy holds the chief portion of the global primary energy mix that comes with the major issue of releasing volatile nuclear wastes viz. radioiodine (129I and 131I) into air and water bodies during nuclear fuel reprocessing. The efficient capture of volatile radioiodine has attracted a major attention worldwide due to the severe health and environment effects. Among various porous materials, covalent organic frameworks (COFs) are the intriguing class of porous organic materials with crystallinity, synthetically pre-designable functionalities to achieve tunable properties. Herein, a new benzothiazole based COF (COF-3) obtained by the condensation of 2,6-dimainobenzothiazole and 2,4,6-triformylpholoroglucinol is reported with tetragonal pore topology (pore volume = 0.305 cc/g; BET surface area = 57.9 m2/g). The electron rich heteroatoms in the frameworks play a crucial role in adsorbing electron deficient iodine molecules and therefore, the benzothiazole-derived COF is envisioned to be potent material for efficient iodine adsorption. The synthesized COF showed the iodine adsorption capacity of 1.07 g g-1 in vapor phase and 109.0 mg g-1 from n-hexane solution. A reference COF (COF-4) with no thiazole group derived from 1,4-phenylenediamine and 2,4,6-triformylpholoroglucinol with hexagonal pore topology (pore volume = 0.937 cc/g) and BET surface area 133.9 m2/g showed adsorption of iodine from n-hexane solution with capacity 149.5 mg g-1. The study revealed that although the presence of heteroatoms in the framework facilitates the iodine adsorption by converting the molecular iodine into the polyiodides; the factors such as BET surface area, pore topology and pore volume also play a major role in the adsorption of iodine molecules.
Digital Inclusion in Motion: Uncovering Physiotherapists' Awareness and Application of Smartphone Accessibility Features
Authors: Thakkar Kevin , Verma Chhaya , Chavhan Nisha
Published: June 2023

Purpose
The main purpose of this study is to evaluate the awareness of physiotherapy professionals regarding the digital accessibility settings on smartphones and their use in patient management. The research question focuses on understanding the level of knowledge and utilization of these settings among physiotherapists.
Methods
This study utilized a survey-based observational cross-sectional design. A questionnaire was developed based on a literature review and underwent peer review for face validity. Physiotherapists actively involved in patient management were selected and asked to complete the survey. The collected data was analyzed to assess the awareness and utilization of digital accessibility settings.
Results
The study collected 100 questionnaire responses from physiotherapists, with a majority of 85% being female and an average age of 24.68 years. The findings revealed that Bold Text was the most commonly used Android feature, while Action Blocks had the lowest awareness and use. For iOS, Text size, Subtitles, and Dictation features were highly utilized, while Action Blocks had the lowest score.
Conclusion
The results highlight the need for increased awareness and education among physiotherapists regarding the digital accessibility settings on smartphones, particularly among those who use Android devices. This education can help physiotherapists better support their patients in optimizing smartphone usage and improving their quality of life. Integrating digital accessibility education into the curriculum or continuing education programs for physiotherapists is recommended to address this knowledge gap and empower patients with disabilities to utilize smartphone features more efficiently.
Research on wheel wear prediction and algorithm improvement based on Data-Driven technology analysis
Authors: Zhang Xu , Niu Hongbo , Chen Bingzhi , Cui Xiangcheng , Xu Jianxin
Published: June 2023

Because they support the entire weight of the train and carry substantial safety consequences, rail train wheels are vital bogie components. As a result, it is crucial to predict tire wear so that early wheel turning or replacement may effectively improve the stability of train operation and the economy of railroad operation. A substantial percentage of wheel wear will occur during travel, impacting safety. Data intelligence may be able to anticipate tire wear more precisely and timely than traditional prediction based on historical experience. As data-driven analysis advances, numerous intelligent algorithms are being employed to the prediction of tire wear. Despite the rapid advancement of data-driven technology, predicting wheel and rail. Regression is used in this paper to forecast wheel wear using complex algorithms. In order to better accurately predict future wheel wear data, this study is based on data-driven technologies for wheel data collection, analysis, filtering, and acquisition. The Particle Swarm Optimization Support Vector Machine (PSO-SVM) model is improved by employing the grid search strategy to minimize the two parameters of the support vector machine's kernel parameter g and the punishment function C. while employing the cross-validation method to prevent overfitting and achieve the regression prediction of wheel wear data. The results of the experiments demonstrate that the improved model generates more reliable results for each prediction. In order to demonstrate how the model affects optimization, the Genetic algorithm for optimization of support vector machines (GA-SVM) mathematical model is optimized for comparative analysis in terms of iteration rate, fitness, and mathematical metrics.
Simulation and Overheating Alert Research for Beam Spot Temperatures on High-Field Side Protective Tiles in EAST-NBI
Authors: Shi Chao , Liu Zhimin , Xu Yongjian , Xu Xingyuan , Yang Daoye , Xie Yuanlai
Published: June 2023

Neutral Beam Injection (NBI), an auxiliary heating method in EAST, is evolving towards higher energy and longer pulses, leading to increased energy bombardment on the high-field side graphite protection tiles. This study explores the intricacies of theoretical injection energy and shine-through losses with respect to plasma density, NBI beam energy, and NBI pulse width. By evaluating the beam power distribution reaching the protective tiles, and subsequently assessing the temperature distribution on the tiles under varying pulse widths, a reliable comparison can be made between the simulated temperature results and experimental temperature data.To ensure the reliability of simulation results, the beam power distribution utilizes a two-dimensional Gaussian model and a particle model for contrast simulation. Similarly, the thermal deposition model employs a simplified uniform heating model and a thermal conduction model. As a reference, the experimentally measured data includes both infrared surface temperature measurements and buried thermocouple measurements.The objective of this study is to establish a correlation between key input variables and the protective tile temperature. By setting precise parameters, this research seeks to provide a predictive mechanism for thermal deposition, contributing to proactive overheating prevention and efficient adjustments to injection parameters and first-wall backend cooling metrics.
Impeding DNA Polymerase β activity by oleic acid to inhibit base excision repair and induce mitochondrial dysfunction in hepatic cells
Authors: Wang Meina , Qi Yannan , Zhou Yu , Zhang Ziyu , Guo Chenxi , Shu Chuanjun , Pan Feiyan , Guo Zhigang , Di Hong-Jie , Hu Zhigang
Published: June 2023

Free fatty acids (FFAs) hepatic accumulation and the resulting oxidative stress contribute to several chronic liver diseases including nonalcoholic steatohepatitis. However, the underlying pathological mechanisms remain unclear. Here, we present a novel mechanism by which FFAs toxicity negatively affects DNA repair activity. Specifically, we found that oleic acid (OA), a prominent dietary free fatty acid, inhibits the activity of DNA polymerase β (Pol β), a crucial enzyme involved in base excision repair (BER), by actively competing with 2'-deoxycytidine-5'-triphosphate. Consequently, OA hinders the efficiency of BER, leading to the accumulation of DNA damage in hepatocytes overloaded with FFAs. Additionally, the excessive presence of OA and palmitic acid leads to mitochondrial dysfunction in hepatocytes. These findings suggest that the accumulation of FFAs hampers Pol β activity and contributes to mitochondrial dysfunction, shedding light on potential pathogenic mechanisms underlying FFAs-related diseases.
Urban planning and landscape greening management drive plant diversity in five tropical cities of China
Authors: Cui Jian-Peng , Zhu Mei-Hui , Guo Lin-Yuan , Zhang Hai-Li , Hughes Alice C. , Wang Hua-Feng
Published: June 2023

Sustainable green space is essential in urban areas to maintain and improve human well-being. However, to better understand the impact of environmental and socioeconomic changes on the sustainability of tropical urban green space landscapes, work is needed to explore the patterns of plant diversity and its drivers in urban green spaces. We explore urban floristic diversity patterns based on samples from 826 urban functional units located in five cities in the tropical coastal region of China. Field surveys were conducted to obtain data on plant diversity, land use types, socioeconomic characteristics, and environmental characteristics within these units. Plant diversity within the cities varied significantly among land use types, with high-rise housing, parks and universities exhibiting higher diversity. The diversity of cultivated plants and regional economy showed significant positive correlation, while an increase in the diversity of spontaneous plants and native species was linked to building age. Management also affected plant diversity, with watering frequency being positively associated and maintenance frequency. Urban plant diversity patterns result from a combination of multiple factors. Socio-economic factors are the primary driver of the patterns of urban plant diversity, as space management and maintenance determine what can grow in different areas. The implications of the study have important practical significance for policymakers and managers in the development and management of urban green spaces more sustainably.
WITHDRAWN: Survival outcomes of NSCLC patients with brain metastases stratified by Lung- molGPA and application and timing of cranial radiotherapy
Authors: Li Ji , Zhai Xiaoyang , Jing Xuquan , Bao Qingdong , Xu Shuhui , Yu Jinming , Zhu Hui
Published: June 2023

Background
Consider the impact of life expectancy for timing of treatment intervention, this retrospective study aimed to evaluate whether predicting timing of cranial radiotherapy (CRT) in NSCLC patients with BM through lung-molGPA index.
Methods
The lung-molGPA scores were obtained and used as a basis to stratify the patients. The effect of radiotherapy timing on survival time in groups stratified by lung-molGPA index was evaluated. Upfront CRT was defined as CRT received within 3 months after initial diagnosis of BM and no progression of BM prior to CRT. While deferred CRT was receiving CRT after progression of BM or initial diagnosis of BM three months later.
Results
In the entire cohort, the median OS and PFS were 17.0 and 9.2 months, respectively. In the lung-molGPA2.5–4 group, the addition of CRT prolonged the OS and PFS of patients (OS = HR: 0.66, 95% CI: 0.48–0.91, P < .001; and PFS = HR: 0.74, 95% CI: 0.54–1.01, P = .001). Moreover, in patients with lung-molGPA score of 2.5–4, the median OS times of the upfront CRT and deferred CRT groups were 26.0 months and 18.0 months, respectively; meanwhile, the OS of the upfront CRT group was significantly superior to that of the deferred CRT group (HR: 0.69, 95% CI: 0.42–1.13, P = .002).
Conclusion
In patients who obtained a lung-molGPA score of 2.5–4.0, upfront CRT could benefit patients’ survival. In patients who obtained a score of 0–2, the survival benefit from CRT was limited.
A newly invaded eucalypt gall wasp and its parasitoid in China: identification and biology
Authors: Li Yuan-Hao , He Xiong Zhao , Wang Qiao , Su Jing-Hui , Wang Xiao-Yun , Chen Shu-Yu , Zheng Xia-Lin
Published: June 2023

Gall pests have caused seriously damage to eucalyptus in recent years in China. In this study, we collected and identified the invaded eucalyptus gall wasp Ophelimus maskelli and its parasitoid Closterocerus chamaeleon for the first time in China. O. maskelli induced two types of gall shape, i.e., blister- and neoplastic-shaped galls. The blister-shaped galls were most likely induced on leaves rather on petioles and stems, while the neoplastic-shaped galls were more frequently found on petioles rather than on leaves and stems. We find that of the four solar orientations, O. maskelli significantly preferred to colonize Eucalyptus trees in the sunnier areas in south over that in west and north with significantly lower gall infestation rate detected in east. The parasitism rate of C. chamaeleon increased from 23.4% in February to 97.4% in March 2023 when the population of O. maskelli galls was low (236.8–251.4 galls/20 branches); however, when gall population increased to a high level (≈ 450 galls/20 branches), the parasitism rate significantly decreased to 26.5% in April, although it raised to 62.6% again in May. Our findings deliver insigne into development of biological control programs of O. maskelli using C. chamaeleon.
Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (RCRS/HIPEC) for Gastrointestinal Cancers: Feasible and Safe
Authors: Ortega Joanna , Harper Brittany , Tyroch Alan H , Hakim Nawar , Gaur Sumit , Elhanafi Sherif , Konstantinidis Ioannis T.
Published: June 2023

Background
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is being increasingly utilized in the treatment of peritoneal surface malignancies. At the same time the use of robotic assistance in major oncological surgeries is increasing nationwide. We describe our initial outcomes with robotic assisted CRS/HIPEC technique (RCRS/HIPEC).
Methods
Our patients are a 40-yo female with BMI 17 and history of signet ring cell gastric adenocarcinoma s/p FOLFOX and robotic total gastrectomy then recurrence 2.5years later found during hysterectomy s/p 6 cycles of 5fu/irinotecan and nivolumab with no radiologically evident disease and a 49-yo female with BMI 37 and recently found low grade mucinous appendiceal neoplasm during appendectomy with radiologically confined disease at the right lower quadrant.
Results
Patients underwent cytoreduction with the use of the Xi robotic system. Peritoneal carcinomatosis index (PCI) was PCI = 4 and PCI = 5. Both patients underwent a complete cytoreduction (completeness of cytoreduction score, CC = 0). Perfusion for 90 minutes with mitomycin C at 41-42C was performed. Estimated blood loss for both cases was less than 50ml, patients returned bowel function at postoperative day 3 and were discharged on postoperative day 5 without complications.
Evaluation of Empirical Antibiotic Therapy in Women with Acute Cystitis Visiting Outpatient Clinic in South Korea
Authors: Jeon Song Hyeon , Kim Taeyeon , Je Nam Kyung
Published: June 2023

Background:
The overuse and misuse of antibiotics is a major public health concern, contributing to the rise of antibiotic-resistant bacteria. This study aimed to determine the prevalence of inappropriate antibiotic prescription for acute uncomplicated cystitis (AUC) in primary care clinics in Korea and identify contributing factors.
Methods:
Data from 20-64-year-old female AUC patients in the Health Insurance Review and Assessment Service-National Patient Sample were analyzed. Four categories of inappropriate antibiotic use were evaluated: inappropriate selection, duration, use of parenteral antibiotics, and multiple oral antibiotics. Multiple logistic regression was used to determine the impact of factors on inappropriate prescriptions.
Results:
Of the 3,125 patients, 2,285 (73.1%) received inappropriate antibiotics. The most common categories were the use of parenteral antibiotics. Institutional, not patient, factors, were the primary contributors to inappropriate prescription. Urology-specialized clinics had more than double the rate of inappropriate prescription compared to other clinics.
Conclusion:
More than 70% of AUC patients received inappropriate antibiotics in Korean outpatient clinics. The data highlights the urgent need for antimicrobial stewardship in the outpatient setting, with AUC as a 'high priority condition'.
Tempering lethal irradiation induced pro-inflammatory responses in lethally irradiated animals by G-003M: A Potential Radio-modifying approach
Authors: Nadella Vinod , Ranjan Rajiv , Gupta Manju , Jain Aklank , Prakash Hridayesh
Published: June 2023

Repair of lethal radiation associated hemopoietic / gastrointestinal syndrome within an amicable post irradiation time is paramount for radio recovery. In this context, our previous studies have demonstrated the significance of CD14+high macrophages are critical for the management of radiation induced injuries. In this study we report that one of our radioprotective formulations (G-003M) potentially inhibited lethal radiation and/or LPS induced NO and Th1 effector cytokines in the exposed macrophages and lethally irradiated animals indicating its M1 dim polarizing capacity. Preconditioning of mice with G-003M before exposure to lethal irradiation (LR) inhibited Th1 effector cytokines in serum, lung, small intestine, and splenic tissue confirming its anti-inflammatory potential in these models. Of note, G-003M mediated M2 polarization of LPS primed iNOS+ M1 effector macrophages indicating its potential to temper plasticity of inflammatory macrophages that are potentially involved in sensitization of lethally irradiated host highlighting its adjunct role in mitigating radiation syndromes and affording radioprotection. G-003M potentially re-programs lethally irradiated macrophages, explicitly demonstrating that re-programming of inflammatory macrophages and / or response by G-003M may contribute to the tissue homeostasis radio recovery
Producing High-quality Seeds of an Heirloom Cabbage in Different Crop Management Systems
Authors: Osmani Jena , Davidson Maria Teresa , Tevlin Sarah , Pérez Héctor E.
Published: June 2023

Small- to midsized farmers in the southeastern United States have expressed interest in reigniting on-farm seed production of regionally adapted high-value vegetable crops. However, a considerable knowledge gap exists related to how locally produced seeds perform in the region. We investigated how the first generation of local, farm-produced seeds compared with the original, nonlocal, certified commercial seed stock in terms of initial germination, seedling vigor, and subsequent vegetative traits of ‘Yukina Savoy’ (Brassica rapa L.), an heirloom Chinese cabbage. Locally produced seeds consistently outperformed seeds of the commercial lot. Germination for local and nonlocal seeds reached 99% and 94%, respectively. However, locally produced seeds germinated 1.5-fold more rapidly than nonlocal seeds, and germination was more uniform in local seeds. Seedlings produced from local seeds appeared more vigorous and displayed a significant height advantage compared with nonlocal seeds when grown in the greenhouse. Likewise, transplants from local seeds maintained an advantage over transplants from nonlocal seeds for plant vigor, growth traits, and harvestable yield during the 4-week field cultivation period. We conclude that production of high-quality ‘Yukina Savoy’ seeds is possible in the southeastern region despite challenging environmental conditions and varied farming practices of our partners during the seed production cycle.
Prospects for diagnostics and treatment of neurofibromatosis type 1 in Russia
Authors: Mustafin R. N.
Published: June 2023

Purpose of the study. Analysis of available data on modern methods of diagnosis and treatment of neurofibromatosis type 1 (NF1) and their application in the Russian Federation. Material and Methods. The search for relevant sources was carried out in the Scopus, Web of Science, PubMed, Elibrary systems, including publications from February 1992 to December 2022. Of the 1873 scientific articles found, 48 were used to write a systematic review. Results. Neurofibromatosis type 1 (NF1) is caused by germline heterozygous mutations in the NF1 gene, which encodes the neurofibromin protein, which suppresses mitogen-activated signaling pathways necessary for cell proliferation. Clinical manifestations of NF1 are similar to Peutz–Jeghers, Laugier–Hunziker, Rusalkab–Muret–Smith, Bannayan–Zonnana, LEOPARD syndromes, neurofibromatosis type 2 and lipomatosis; therefore, to confirm the diagnosis, the most important criterion is the detection of a gene mutation by sequencing, since there are no mutagenesis hotspots in the NF1 gene. To detect 17q11.2 locus microdeletions, MLPA method is used. In Russia, such methods of molecular genetic identification of NF1 were carried out in Moscow and in the Republic of Bashkortostan. Surgical interventions using a neodymium laser and therapy with mitogen-activated protein kinase inhibitors are the most effective for the treatment of tumor syndrome. Scientific results of the use of a surgical laser in the treatment of plexiform neurofibromas and extramedullary tumors of the spinal cord have been published in Russia. Treatment of NF1 with selumetinib in Russia was announced by the interregional public organization for assistance to patients with neurofibromatosis “22/17”, which provides the drug to children with inoperable neurofibromas free of charge. Conclusion. In modern medicine, it is necessary to widely use methods for identifying mutations in the NF1 gene by creating universal panels of targeted sequencing. This will allow not only the differential diagnosis of NF1, but also the identification of the cause of chemoresistance of sporadic malignant neoplasms for the introduction of mitogen-activated protein kinase inhibitors in their treatment. Combination of this method with surgical excision of neurofibromas using a neodymium laser is optimal.
Relationship between cluster miR-143/145 micro-RNAs with oncogenesis: tissue and cellular context
Authors: Voropaeva E. N. , Pospelova T. I. , Nesterets A. M. , Maksimov V. N.
Published: June 2023

The purpose of the study was to present up-to-date data on the regulation of expression, function in normal tissues and multidirectional activity in the oncogenesis of miR-143/145 microRNAs cluster, as well as to evaluate the possibilities and limitations of the therapeutic use of microRNAs of this cluster in malignant neoplasms. Material and methods. The search for available domestic and foreign literary sources published in PubMed and RSCI databases over the past 10 years has been carried out. 427 articles were found, of which 41 were included in this review. Results. The conservative cluster miR-143/145 is one of the most intensively studied in tumors. Based on the results of the analysis of differential miRNA expression, in vitro experiments in cancer cell lines and in vivo in mouse tumor models, a decrease in miR-143 and miR-145 levels was shown in malignant neoplasms of epithelial origin. Until recently, these miRNAs were considered classical oncosuppressors. The data presented in the review demonstrate that the results of a number of studies taking into account the cellular aspects of microRNA expression contradict this concept. miR-143 microRNA, for example, is known to participate in the metabolic restructuring of the tumor and the activation of neoangiogenesis. It has been shown that the oncosuppressive or pro-oncogenic activity of miR-143 and miR-145 depend on the tissue and cellular context and can be explained by the presence of several regulated targets that have opposite effects on oncogenesis. Taken together, the data obtained suggest the need to exercise caution when choosing the microRNAs of the described cluster for exogenous therapeutic delivery. Conclusion. Further detailed decoding of the mechanisms of miR-143 and miR-145 functioning in various types of tissues and cells, as well as identification of new MRNA targets are necessary for a better understanding of the involvement of these molecules in oncogenesis.
The аntitumor effect of 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol) on the growth of spontaneous mammary tumors in HER-2/neu transgenic mice
Authors: Alexandrov V. A. , Stukov A. N. , Zmitrichenko Yu. G. , Tochilnikov G. V.
Published: June 2023

Background. Current treatment of HER2-positive metastatic breast cancer (BC) is based on the use of anti-HER2 blockers as pathogenic drugs, as well as the search for the optimal combination of anticancer drugs with different mechanisms of action. The potential activity of chlonisol in HER2+ ВС is of great interesting. The aim of the study was to evaluate the antitumor effect of 2-[3-(2-chloroethyl)-3-nitrosouriedo]-1,3-propanediol (chlonisol) on the growth of spontaneous mammary tumors in HER-2/neu transgenic FVB/N mice. Material and Methods. A prospective study used 5-month-old female mice with HER2-positive mammary tumors. Of these animals, ten pairs with almost the same size of tumors were formed (respectively, for the control group and the chlonisol treatment group). Chlonisol was administered at a dose of 20 mg/kg intraperitoneally, once. The animals were followed up for 30 days. Results. In all ten pairs of mice, chlonisol showed a significant antitumor effect, up to a complete temporary regression of the tumor. When summing the comparative results of all ten pairs of animals, the inhibition of tumor growth (ITG) in the chlonisol treatment group was 90-97 % (p<0.0001), and the area under the kinetic curve of tumor growth was 13.6 times less than in the control group (p<0.0001), thus indicating a significant effect. Conclusion. Chlonisol has a high therapeutic activity by inhibiting the growth of spontaneous HER2-positive breast tumors in FVB/N mice.
QR-code-based payment. Does the consumer intend to adopt a retail buying transaction?
Authors: Widayat Widayat , Marsudi  , Masudin Ilyas
Published: June 2023

The Quick Response (QR) code payment is a relatively new means of payment in Indonesia. Even though this strategy offers a great deal of use, not many people are familiar with it or use it. In this regard, it is fascinating to look at what makes people use the QR Code payment method. The quantitative study used a five-point Likert scale questionnaire to sample e-money users through social media groups. In addition, structural Equation Modeling (SEM), employee Smart-PLS 3.0, was used to examine the data. The results show that social factors affect how people feel about QR code payments, and facilitating support and performance expectations affect how likely they are to use it. Also, attitudes, a mediator of social impact, can change the effect of support performance expectations on adoption intentions. Because of this, people accepting QR code-based payments take a positive attitude. Also, the facilities and environment affected a positive attitude, expected performance, ease of operation, and social interactions. Based on the results, the recommendation for financial institutions and innovation is that the facility and social environment are critical to the success of financial innovation. So, if more people want to use QR code-based payments, financial institutions need to make it easy for them.
AcknowledgmentThe author would like to thank the Rector, Vice-Rector of the University of Muhammadiyah Malang. Furthermore, the author sincerely thanks the University of Muhammadiyah Malang’s Dean of Business and Economics Faculty. A University of Muhammadiyah Malang’s School of Economics and Business member supported finishing this paper.
Musealización de tejidos y preservación de la historia: el caso del vestido expuesto en el Museu do Doce de Pelotas/RS
Authors: Pereira da Silveira Laiana , Robaina Iglécias Daisiane
Published: June 2023

A través de este estudio es posible observar cómo la indumentaria expuesta en el museo mantiene en evidencia la historia, destacando la importancia de los objetos de indumentaria conservados y preservados en las colecciones de las instituciones museológicas. Para confirmar tal observación, la investigación presenta - a través de investigación bibliográfica y visita - un estudio de caso en el que el objeto principal es una prenda de vestir, objeto perteneciente al acervo del Museu do Doce, localizado en la ciudad de Pelotas, en el interior de Rio Grande do Sul. El vestido musealizado y expuesto representa una cultura específica de la ciudad que mueve el turismo, la economía, entre otros factores. El estudio concluye a través de la observación, la importancia que existe en la conservación y preservación de los objetos textiles en la institución museológica en cuestión, ya que, son fuentes ricas para la preservación de la historia local y futuros estudios sobre una sociedad o época en particular.
Military Medical Training at the Central Institute for the Advanced Medical Education in the Second Half of the 1930s
Authors: Kaymashnikova Elena B. , Genina Elena S.
Published: June 2023

The paper describes the initial stage in the organization of military medical training at the Central Institutefor Advanced Medical Education (CIAME), now the Russian Medical Academy for Continuous Professional Educationat the Ministry of Health of the Russian Federation, Moscow. The problem statement in this study is the first of itskind in Russian historiography. The research relied on the documents found in the Russian State Archive of Scientificand Technical Documentation and the Archive of the Russian Medical Academy of Continuous Professional Education.The decision to establish a military medical department at the CIAME was made in 1936. The authors identified the main tasks and challenges the new department had to face, as well as solution methods, areas of theoretical and practical training,and curriculum. The article also describes the role of the CIAME in the Battle of Khalkhin Gol in 1939 and the WinterWar of 1939–1940. In the second half of the 1930s, the CIAME medical staff acquired experience in military medicaltraining and medical care in combat conditions, which proved invaluable during the Great Patriotic War of 1941–1945.
Soviet Response to the European Atomic Energy Community (Euratom)
Authors: Todykov Egor S.
Published: June 2023

This article discusses the way the USSR reacted to the creation of the supranational European Atomic Energy Community (Euratom). The authors believe that the Soviet criticism of German and French nuclear programs was, at least, partially, objective and non-ideological. The study featured documents on Soviet foreign policy that described the initial reaction of the USSR to the Euratom plans, suggested alternative options for European cooperation in the field of peaceful nuclear energy, and showed the evolution of the Soviet approach to European integration. Western Europe and the United States had their own goals in the development of the peaceful nuclear industry in Europe. The fears expressed by the USSR were related to the membership of the Federal Republic of Germany in Euratom and the role the United States intended to assume in this organization. Eventually, Moscow accepted a more neutral position in relation to the Euratom and other integration processes in Western Europe.
Historical Necropolis of Jewish Subbotniks in the Town of Zima, Irkutsk Region
Authors: Berman Elena A.
Published: June 2023

The Subbotniks, or gers, were Russian Sabbatarians. The article describes a necropolis of exiled Jewish Subbotniks founded in the village of Zima, Irkutsk Province, in the early 1830s. The Subbotniks shared the necropolis with the Jews since both exile communities maintained close routine and religious contacts. The research objective was to catalog the authentic tombstones of 1865–1947 and determine the influence of Judaism on the religious life the Subbotniks. The article gives a general description of the Sabbatarian sects that appeared among Russian peasants at the turn of the XVIII–XIX centuries and explains how they ended up in the Irkutsk Province. The author studied the Jewish burial and mourning practices adopted by the Subbotniks and compared the Zima necropolis with traditional Jewish cemeteries. The descriptions of tombstones and epitaphs were collected during the expeditions of 2017 and 2019.

The surviving tombstones were cataloged, and the epitaphs were translated from Hebrew into Russian to compile a list of those buried in the cemetery during the period in question. The research also included the tombstones that belonged to the Jews who lived in Zima in the XIX – early XX centuries.