bluuebunny/crossref_metadata_2025 huggingface dataset:
Engaging young learners of English with digital stories: Learning to mean
Authors: Lestariyana Reni Puspitasari Dwi , Widodo Handoyo Puji
Published: October 2018

Using a digital story to teach English to pupils in primary schools is not a new enterprise in the field of TESOL. However, this learning platform remains under-practiced in Asian primary schools where English is socio-politically viewed as a foreign language. To fill this gap, we implemented digital storytelling (DST) to engage children in the creation of digital stories and in learning to mean in a multimodal way. This article specifically describes our experience of using DST as pedagogical innovation with pupils of 10-12 years old. In this DST project, pupils jointly created digital stories as multimodal texts. In this respect, they utilized different linguistic resources (e.g., Javanese, Bahasa Indonesia, and English) as well as visual and technological affordances, which assisted them in voicing their real-life experience through digital stories. The practical implication of the project is that primary school teachers of English can experiment with DST to engage pupils in meaningful project-based language learning.
Vygotsky: Between Socio-Cultural Relativismand Historical Materialism. From a Psychologicalto a Pedagogical Perspective
Authors: Daniels H.
Published: October 2018

In this paper I draw a distinction between two strands of argument that have evolved in the wake of Vygotsky’s early 20th century writing. I examine key methodological differences between sociocultural relativism and historical materialism. I then consider the pedagogical implications of these differences. My concern is that the all too common western predeliction for a post modern account yields a deeply conservative approach to pedagogy. In this form pedagogy may loose its power as a tool of social transformation and may curtail the possibilities for individual transformation. I close with a quote which neatly captures this concern: “Methodology is not a "toolbox" of different methods from which the researcher selects some on the basis of personal or social preferences! Instead, it is an integrated structure of the epistemological process (Branco & Valsiner, 1997) that can equally and easily reveal and obscure the empirical reality in the knowledge construction process of social scientists”.
Interpsychological Exists!
Authors: Zuckerman G.A. , Ryabinina L.A. , Chaban T.Y. , Romanova L.M.
Published: October 2018

Is there a joint, cooperative action taking place every time pupils do something in fours in a lesson, for instance, discuss the content of a text according to the task given by a teacher? Using clinical research of simple child-adult interactions, we explain how the following essential features of interpsychological action can be found in children’s activities: (1) a child’s initiative in solving the task (2) intersection of children’s initiatives upon the object of their activities (3) orientation of children’s individual actions both towards the object of their activities (in this case, the meaning of the text) and the partner (his/her understanding of the sought-for meaning) (4) unfinished, in-progress character of the ability to understand text in every child participating in the interaction (5) nonadditive character of the interaction outcome which exceeds the individual abilities of the participants (6) stability of the achieved outcome, its persistence in individual actions even outside the interaction (7) specially arranged activities of the adult participant of the interaction. At the project stage, the adult creates the focus in which the children’s initiatives can meet. In our case, it was a question to the text which implied reflective understanding that was only beginning to emerge in second-year pupils. At the stage of direct interaction, the adult (1) supports productive initiatives of the children, yet restraining from full participation in solving the task (2) protects the child community from unproductive conflicts arising due to violations of communicative norms.
Trial Action: Conditions for Initiation
Authors: Elkonin B.D. , Semenova V.N.
Published: October 2018

The paper presents outcomes of experimental modeling of the conditions for initiating trial action. The hypothesis of our research was that the initiation of the trial action becomes possible when two opposed positions are set within a single action. The trial action was considered the ‘centre’ of retention of two tenden cies of acting — result- and orientation-based. As for the technique, we decided to design the tasks in such a way that they would result in the construction of some object, and this process would, at the same time, display the features of the very field of acting. The research involved 52 subjects aged 7—22 years (students of state schools and universities of Moscow). Using nonparametric methods of mathematical statistics, we revealed several levels of performance characterized by different ‘degrees of trialness’ of the action. The paper describes phenomena that provide evidence of the trial action formation, and also discusses a method of overcoming performance in the trial, rethinking of the task, that was revealed during the experiment. cies of acting — result- and orientation-based. As for the technique, we decided to design the tasks in such a way that they would result in the construction of some object, and this process would, at the same time, display the features of the very field of acting. The research involved 52 subjects aged 7—22 years (students of state schools and universities of Moscow). Using nonparametric methods of mathematical statistics, we revealed several levels of performance characterized by different ‘degrees of trialness’ of the action. The paper describes phenomena that provide evidence of the trial action formation, and also discusses a method of overcoming performance in the trial, rethinking of the task, that was revealed during the experiment.
Decolonizing Methodologies: A Transformation from Science- Oriented Researcher to Relational/Participant-Oriented Researcher
Authors: Datta Ranjan
Published: October 2018

This paper outlines an ongoing unlearning and relearning journey: my lifelong transformation from a Western scientific researcher to a relational and participant-oriented researcher. This transformation has made me aware of my responsibility to share my stories about how I have changed. In this commentary I situate my lifelong research training as a metaphor for unlearning, learning, situating, and reclaiming my research methodologies and methods. Specifically, this commentary poses and answers questions such as, “how has my Western science-oriented research training been challenged through my relationships with research participant communities? How did my methodological transformation (decolonizing and reclaiming of relational/participant orientation) start? And, how did my transformation empower me and create my sense of belonging in regards to who I am and what I should do?” I conclude by outlining the implications of my methodological transformation processes for future research.
To the issue of differential diagnosis of ANCA-positive generalized sarcoidosis and ANCA-associated polyangiitis
Authors: Koval’skiy G. B. , Ariel' B. M. , Volchkov V. A. , Danilova I. A. , Poliyevets A. G.
Published: October 2018

An autopsy case of a female patient of 65 years old was reported in the article. This case demonstrated clinical and anatomical features of chronic generalized sarcoidosis  with predominant lesion of the lungs (extended bilateral fibrosis) and the kidneys  (interstitial nephritis with segmental glomerulosclerosis). Long-term steroid therapy  resulted in a significant slowing progression of the disease. This case was  characterized by a prominent vasculitis which caused the misdiagnosis of ANCA- associated polyangiitis. Severe anemia and secondary immunodeficiency that were  partially druginduced due to the long-term steroid therapy were other manifestations  of this disease. The advanced disease was complicated by lower respiratory tract  infection, acute respiratory distress-syndrome, and multiple organ dysfunction that  caused the patient’s death. A comprehensive pathological investigation including immunohistochemistry had the crucial role for the final diagnosis.
Antibacterial inhalation therapy with thiamphenicol glycinate acetylcysteinate in pulmonology
Authors: Kapustina V. A. , Ovcharenko S. I.
Published: October 2018

Thiamphenicol glycinate acetylcysteinate (TGA) is a combination of thiamphenicol, a broad-spectrum antibiotic, and mucolytic drug N-acetylcysteine. This article is a  review of pharmacological, microbiological, and clinical effects of this combined drug.  Inhaled TGA could be considered as a worthy alternative for oral mucolytics and oral  antibiotics in treatment of upper and lower airway diseases, such as acute and chronic  rhinosinusitis, otitis media, tonsillitis, acute bronchitis, and acute exacerbation of chronic bronchitis and chronic obstructive pulmonary disease, in children and adults.
Adrenal Collision Tumor Composed of Pheochromocytoma and Diffuse Large B-Cell Lymphoma: A Case Report
Authors: Khorsand Atieh , Khatami Fatemeh , Sefidbakht Salma , Saffar Hiva , Sadeghipour Alireza , Tavangar Seyed Mohammad
Published: October 2018

Adrenal involvement in the course of malignant lymphoma occurs in about 4% of patients, but primary adrenal lymphoma (PAL) is extremely rare. To the best of our knowledge, only one case study reported the combination of PAL with pheochromocytoma. In the current study, we present the second case who was a 63-year-old man admitted to our hospital with hematuria and abdominal discomfort. Ultrasound imaging indicated the presence of a lesion, 5×4×3 cm in size, in the upper pole of his right kidney. Histopathologic study confirmed a collision tumor composed of pheochromocytoma and diffuse large B-cell lymphoma (DLBCL).
Keywords: Collision tumor, Diffuse large B-cell lymphoma, Pheochromocytoma
Unexplained Pancytopenia in a Patient with 5q35.2-q35.3 Microduplication Encompassing NSD1: A Case Report
Authors: Park Sungwoo , Lee Gyeong-Won , Koh Eun-Ha , Kim Hyun-Young
Published: October 2018

The 5q35.2-q35.3 duplication phenotype is characterized by growth delay, microcephaly, mental retardation and delayed bone aging. However, there has been no reports on the occurrence of pancytopenia as a consequence of 5q35.2-q35.3 duplication. A 42-year-old male visited the emergency room due to multiple trauma. He had been diagnosed with mental retardation in the past. No previous history of severe bleeding symptom was also reported. Complete blood cell counts were leukocyte 3.51×109/L, neutrophil 0.19×109/L, hemoglobin 8.3 g/dL, hematocrit 25.0%, and platelet 4.0×109/L. There was no relevant history of any medication intake and there were no other haematological parameters leading to the persistent pancytopenia. A bone marrow biopsy revealed hypercellular marrow with increased trilineage hematopoiesis. The uptake of fluorodeoxyglucose was increased in multiple lymph nodes, bone and spleen in positron emission tomography–computed tomography. A biopsy of the right axillary lymph node was performed and histologic findings were unremarkable. The chromosomal microarray revealed a 3.46 Mb microduplication at the 5q35.2-q35.3 site including NSD1. The patient had distinctive features related to atypical pancytopenia. Various managements for pancytopenia had no effect on the patient. However, there were no complications such as massive bleeding or serious infection compared to the severity of pancytopenia during a follow-up of 3 months. In addition, periodic patterns of deterioration and improvement in pancytopenia appeared spontaneously. Since it is rare for these distinctive features of pancytopenia and chromosomal abnormality to coexist, it is important to investigate the association. In the current study, we describe the first case of 5q35.2-q35.3 microduplication encompassing NSD1 with unexplained pancytopenia. 
Keywords: Pancytopenia, Chromosomal abnormality, Microarray
Clinical Characteristics and Prognosis of Primary Tracheal Cancer: A Single Institution Experience
Authors: Koul Rashmi , Alomrann Reem , Rathod Shrinivas , Kim Julian , Leylek Ahmet , Ahmed Naseer , Bashir Bashir , Chowdhury Amitava , Tan Lawrence , Dubey Arbind
Published: October 2018

Background Primary tracheal cancers (PTCs) are rare and current evidence-based understanding is limited to retrospective reports and national databases. We present single institutional study of a historical cohort of PTC from Canadian provincial cancer registry database.
Materials and Methods: After institutional research ethics board approval, all PTC patients diagnosed from 1980 to 2014 were identified through the Canadian provincial cancer registry. Demographic and tumor related factors were evaluated using descriptive statistics. Survival rates were estimated using the Kaplan-Meier method and cox hazard regression analyses were performed to identify predictors of disease-free survival (DFS) and overall survival (OS).
Results: A total of 30 patients were included in the study. At presentation, 10 patients (33%) had only local disease, 14 patients (47%) had locoregional disease and the remaining 4 patients (13%) had distant metastasis. The majority of patients underwent primary radiation treatment. The overall survival rate was 30% at 2 years and 16% at 5 years. Patients receiving radical-intent therapy had better 2-year DFS and OS compared to patients managed with palliative radiotherapy and best supportive care (46%, 17% and 0%) (p=<0.001) and (50%, 23% and 0%) (p=<0.001), respectively. Radiotherapy resulted in a better 2-year OS and DFS (32% versus 14%) (p=<0.03) and (32% versus 0%) (p=<0.001), respectively.
Conclusion: PTC is an uncommon neoplasm making the study of the disease technically and logistically challenging. Radical radiotherapy alone is curative option in inoperable PTC. Intent of treatment and radiotherapy were associated with superior survival outcomes.
Anxiety, Coping and Social Support Among Parents Who Have Children with Chronic Kidney Disease
Authors: Zengin Oğuzhan , Erbay Ercüment , Yıldırım Buğra
Published: October 2018

Objective: Present study has been conducted to investigate anxiety levels, coping strategies, social support systems among parents who have children with chronic kidney disease and interrelations among the three indicators. Methods: This study has been planned among parents of 180 children with a chronic kidney disease being admitted to Hacettepe University, Children's Hospital, Nephrology Polyclinic. Sociodemographic information form, state & trait anxiety inventory and short form of the assessment scale for coping strategies have been employed as data gathering tools. Results: With respect to gender it was detected that mothers resorted to selfdistraction coping strategy and with respect to educational level, parents with no formal educational background resorted to denial. Trait anxiety score was the highest among parents whose children were in the second stage of disease. As the coping strategies among parents receiving social support in the treatment process was examined, it surfaced that positive reframing, acceptance, humor and use of emotional support and similar problem-focused coping strategies were more frequently opted for. Contrary to that, it was identified that among parents receiving no social support from their relatives, scores of self-blame, substance use and state anxiety were relatively higher. Conclusion: At the end of this study it was concluded that parents having children with a chronic kidney disease were more effective in utilizing social support mechanisms as a problem-focused coping strategy when compared to the other group of parents.
Experience and Expectation of International Students: Over Barclays Bank, Service Quality in Chester, UK
Authors: Yeoward Ms Joyce , Ashwathnarayana Mr Prapul Kumar
Published: October 2018

In the 21stcentury service industry has grabbed and changed the phenomenal look of the business market, as service is an endless endeavor of any product, which is delivered as soon the product is launched in the market, and people are more depended on services, which has become an essential needs for them. When service is delivered to the customer the services providers’ has to maintain the quality of services, which might be beyond the expectation of the consumers, which will lead in a better level of satisfaction and elevate the organizations reputation. In the banking sector the main expectation of the customers is assurance, reliability, responsiveness taken by the bank, if the consumers are pleased by the services, then the bank accomplishes the purpose of satisfying the customer and delivering all their needs. In this research the researcher has considered the aspects of satisfying the expectations of customer, through the values of services quality and to understand the gap between experience and expectation by adopting SERVQUAL model and gap analysis, these helped the researcher to showcase the services quality provided by the Barclays bank Chester to the international students. By adopting the above model the researcher has conferred that the services provided by the Barclays bank has tried to satisfy the customer and the overall gap of expectation and satisfaction has showed positive score of (+ 2.26) this also describes that by providing more better and quality services, the customer satisfaction score can be improved. This also can be observed in future by carrying out other research programs on the same topic on larger demographic or international scale.
CHICO BENTO NA ESCOLA: UMA INTERVENÇÃO PEDAGÓGICA SOBRE O TRABALHO
Authors: CUNHA BIANCA AMARAL DA , FARIA ANTÔNIO AUGUSTO MOREIRA DE
Published: October 2018

A relação entre as esferas da escola e do trabalho cotidianamente parece estar clara, mas quando se mergulha na questão, se descobre que é muito mais complexa, especialmente para os estudantes. Estes, expostos aos mais variados discursos e textos, assimilam, sem muita reflexão, as ideias mais presentes na mídia e no ambiente familiar, de maneira que os conhecimentos adquiridos sobre o trabalho se dão de modo informal. Por outro lado, os Parâmetros Curriculares Nacionais (PCN) orientam que a escola colabore para a formação do trabalhador, inserindo o tema Trabalho de forma transversal nos conteúdos escolares. Este artigo, que é resultado de parte de uma pesquisa do Mestrado Profissional em Letras (PROFLETRAS – UFMG), analisa uma intervenção pedagógica, realizada com alunos do 6º ano do ensino fundamental, em que se utilizam histórias em quadrinhos (HQ) do personagem Chico Bento como ponto de partida para tratar do tema Trabalho. O objetivo da proposta foi contribuir para o desenvolvimento de atividades que relacionem o gênero textual HQ e o tema transversal Trabalho dos PCN. Os resultados da pesquisa, norteada pelas orientações sobre Trabalho e ensino de Língua Portuguesa dos PCN (BRASIL, 1998) e ancorada em pressupostos teóricos da leitura e análise de textos (FARIA, 2016; FIORIN, 1988; FREIRE, 1989; ROJO, 2004), ressaltam a importância e as contribuições de propostas pedagógicas sobre o Trabalho para a formação do cidadão.
LETRAMENTO DIGITAL: OS DESAFIOS DA RELAÇÃO DISCENTE-DOCENTE
Authors: CASTRO NERY SIOMARA , COSTA STEFANIE RODRIGUES , SOUZA MARIZÉTE SILVA
Published: October 2018

O presente artigo objetiva apresentar resultados preliminares de um estudo sobre letramento digital desenvolvido no curso de graduação em Letras.  Destaca, inicialmente, a relação entre a nova era digital e o letramento no contexto da educação escolar e da correlação discente-docente, com ênfase na adequação do docente em meio à nova e desafiadora realidade das redes. Serão analisados, pois, primeiramente, a dinâmica nas relações que envolvem troca de informações e como transcorreu a passagem da leitura do meio físico – através de livros e/ou documentação escrita – para o ambiente virtual das redes. Em seguida, será analisada a relação de inclusão e exclusão digital que ocorre entre os indivíduos e como sucede-se a relação discente-docente com a tecnologia nas salas de aula. A importância de discutir de modo aprofundado esse conceito nos cursos de graduação justifica-se pela necessidade de adequar as práticas leitoras desenvolvidas nas salas de aula à esse universo das tecnologias encaradas aqui como instrumentos de construção de saber significativo no processo pedagógico desenvolvido dentro e fora das escolas.
EDUCAÇÃO DO CAMPO E AGROECOLOGIA: POR UMA PEDAGOGIA DO TRABALHO
Authors: Pereira Kelci Anne , Silva Valcilene Rodrigues da , Sá Mara Franco de
Published: October 2018

O presente trabalho trata-se de uma pesquisa em andamento realizada por docentes do curso de Licenciatura em Educação do Campo, da Universidade Federal do Piauí (UFPI), e objetiva responder aos seguintes questionamentos: De que modo o princípio educativo do trabalho tem sido realizado (ou não) no curso? Esse processo insere a agroecologia como uma pauta transversal do curso, no que diz respeito à formação de professores das ciências sociais e humanas? As culturas do trabalho e as pedagogias da produção camponesa são apreciadas como ponto de partida das práticas pedagógicas do curso e enunciadas como ingredientes de uma práxis emancipatória? Para responder a tais perguntas, a pesquisa irá se ancorar no referencial teórico do materialismo histórico dialético, fazendo usos de instrumentos como questionário, grupos focais, teatro do oprimido, etc. A expectativa é fortalecer o projeto político pedagógico do curso, integrando ao mesmo o trabalho como princípio educativo para uma formação crítica e transformadora.
O RECONHECIMENTO NO TRABALHO DE MOTORISTAS DE TRANSPORTE COLETIVO URBANO
Authors: Gonçalves Júlia , Tolfo Suzana da Rosa , Schweitzer Lucas
Published: October 2018

O reconhecimento no trabalho possui um importante papel enquanto fortalecedor da identidade e protetor da saúde psíquica do trabalhador. Este estudo buscou identificar os aspectos do trabalho de motoristas de transporte coletivo urbano relacionados ao reconhecimento. O referencial teórico utilizado foi a Psicodinâmica do Trabalho. Na pesquisa, de abordagem qualitativa e de caráter descritivo-exploratório, foram realizadas observações nos ambientes de trabalho utilizados pelos motoristas, como terminais do ônibus, linhas e empresa ,e entrevistas coletivas, que foram submetidas a análise de conteúdo. Nos resultados percebeu-se que há uma diversidade de sentimentos que estão associados ao trabalho e sua organização. As vivências de prazer mostraram-se associadas, principalmente, as diferentes formas de reconhecimento no trabalho. Ao mesmo tempo em que existe um auto reconhecimento e um reconhecimento da empresa, de passageiros e da comunidade sobre a importância do trabalho do motorista gerando satisfação e autoconfiança que faz com que construam uma imagem e visão de si positiva enquanto profissionais.
OS RISCOS ERGONÔMICOS NO COTIDIANO DAS EQUIPES DE ENFERMAGEM
Authors: De Andrade Beatriz Botelho , Santos Leila de Fátima , Torres Lilian Machado
Published: October 2018

O profissional ao desempenhar um trabalho se expõe aos riscos a ele relacionados, podendo adoecer física e mentalmente, devido às mudanças nos processos laborais, associadas ao ritmo intenso e longas jornadas. Os trabalhadores da equipe de enfermagem, especificamente, prestam assistência direta ao indivíduo, em longos períodos de tempo, o que aumenta a exposição aos riscos ocupacionais. Revisão integrativa de literatura nacional e internacional cujo objetivo foi identificar os riscos ergonômicos no cotidiano das equipes de enfermagem. A busca foi realizada em quatro bases de dados, aplicando-se os filtros “texto completo” e “publicações a partir de 2012”. Após o refinamento foram obtidos 27 estudos para análise. Do total, sete citaram a dor lombar como manifestação mais significativa na equipe de enfermagem, com prevalência variando de 21,2 a 75%. Outras áreas corporais citadas foram: braços e punhos, pescoço, ombros, pé/tornozelo, costas, pescoço e ombro esquerdo. Os fatores de risco para os distúrbios musculoesqueléticos encontrados estão relacionados ao tipo de trabalho exercido, ao setor de trabalho, às longas e exaustivas jornadas de trabalho, à sobrecarga de trabalho, postura inadequada entre outros. Fica evidente a necessidade de implantação de programas de saúde que visam a promoção da saúde e prevenção de agravos, além de monitoramento dos trabalhadores quanto à saúde física e mental, com vistas à melhora da qualidade de vida no trabalho.
A PRESENÇA DA MULHER NA POLÍTICA: O PROTAGONISMO DE EUNICE MICHILES NO SENADO FEDERAL
Authors: Vale Michelle Souza
Published: October 2018

Este estudo assume o propósito de verificar a participação das mulheres na política representativa, dando especial relevo ao protagonismo de Eunice Michiles no Senado Federal. Ou seja, busca-se averiguar de que forma ocorreu a participação da primeira mulher senadora do Brasil, dando ênfase ao seu protagonismo político. Nossa intenção consistiu em identificar a forma de atuação de Eunice Michiles no Senado Federal, apontando os seus principais projetos voltados para as mulheres. Algumas conquistas das mulheres obtidas pelo movimento feminista da época foram decisivas para a chegada delas ao parlamento.
A Grid Connected Photovoltaic Generation System With Compensation Of Current Harmonics And Voltage Sags
Authors: Cavalcanti Marcelo Cabral , Azevedo Gustavo Medeiros de Souza , Amaral Bruno de Aguiar , Neves Francisco de Assis dos Santos , Moreira Davi Carvalho , Oliveira Kleber Carneiro de
Published: October 2018

This paper presents a system that provides photovoltaic generation as well as the ability to compensate current harmonics and voltage sags. The system can be controlled for current harmonics and reactive power compensation simultaneously by using a converter operating as shunt active filter. Another converter is used as active series filter and it compensates voltage harmonics and voltage sags and swells. Using only one dc-ac converter in photovoltaic energy conversion process, the system presents increased efficiency when compared to the conventional systems, composed by a dcdc converter and a dc-ac converter. The synchronous reference frame method is used to control the three-phase converters. Simulation results demonstrate the good performance of the proposed configuration. Experimental results corresponding to the operation of the series filter as voltage sag compensator are presented.
Sincronismo De Sistemas De Geração Distribuída Baseado Em Modelos Monofásico E Trifásico De Filtro De Kalman
Authors: Pádua Marcelo S. , Deckmann Sigmar M. , Marafão Fernando P. , Lopes Amauri , Moreira Alexandre C.
Published: October 2018

Considerando o crescente interesse em sistemas de Geração Distribuída (GD), este artigo apresenta uma alternativa para sincronização de geradores com a rede elétrica que faz uso do Filtro de Kalman (FK) para identificação da amplitude, do ângulo de fase e da freqüência das tensões fundamentais da rede e do gerador, mesmo na presença de perturbações nas formas de onda. Baseado nos sinais senoidais de tensão de um sistema de energia elétrica, dois métodos são apresentados e desenvolvidos através de variáveis de estado: um para o caso de sistemas monofásicos e outro para o de trifásicos. Em seguida, é proposto um método simplificado para obtenção da freqüência fundamental da(s) tensão(ões) medida(s) com base no ângulo de fase instantâneo. Considerando diferentes condições para o sinal de entrada, será mostrado através de resultados de simulação que, apesar da dinâmica da filtragem ser dependente dos ruídos de medição e de estado, bem como do estado inicial do sistema, os algoritmos são perfeitamente capazes de identificar as informações requeridas. Para analisar o comportamento do FK em um sistema prático, resultados experimentais foram obtidos, através de um sistema de aquisição e de processamento de dados, durante a conexão de uma máquina síncrona com a rede.
DOĞU KARADENİZ ÜNİVERSİTELERİNİN KURUMSAL İLETİŞİMDE SOSYAL MEDYA KULLANIM ALIŞKANLIĞI
Authors: YAVUZ Cavit , DUVAN Yasin
Published: October 2018

Web siteleri; kurum ve kuruluşların/organizasyonların dünyaya açılan kapısı olarak görülmektedir. Özellikle
web2.0’ın hayata geçmesiyle tüm dünyayı saran sosyal ağlar, kullanım kolaylığı, karşılıklı iletişime olanak
sağlaması, ulaşım rahatlığı ve sürekli güncel olması gibi sebeplerle başta gençler olmak üzere hedef kitleye
ulaşmada en sık kullanılan iletişim ortamlarının başında gelmektedir. Kurumun varlığını sürdürebilmesi için kurum
ile çevresi arasında sürekli bilgi ve düşünce alışverişine imkan sağlayan bir iletişim ve ilişki yönetimi süreci olarak
tanımlanan kurumsal iletişim ile sosyal medyanın sağladığı kolaylıkların benzer özellikler göstermesi, kurumları
giderek artan şekilde kurumsal iletişimde sosyal medyayı kullanmaya yöneltmektedir. Artık kurumlar, “sosyal
medyayı kurumsal iletişim alanında kullanmalı mıyız?” sorusundan öte, “onu etkili bir biçimde nasıl
kullanabiliriz?” sorusuna cevap aramaktadır. Kurumsal web siteleri kamunun artan bilgi ihtiyacına karşılık vermek,
kurumun/organizasyonun yapısı, hizmetleri, ürünleri hakkında kullanıcıları bilgilendirmek, kurumun duyuru,
tanıtım ve reklamını yapmak, kurumun amaç ve hedeflerini kamuya aktarmak gibi sayılabilecek pek çok alanda
önemli ihtiyaçlara cevap vermektedir. Doğu Karadeniz Bölgesi’nde yer alan devlet üniversitelerinin sosyal medya
hesaplarının gözlemlenerek, kurumsal iletişimde sosyal medya kullanım alışkanlığının tespit edilmeye çalışıldığı
araştırmanın sonucunda; sosyal medya kullanımlarında benzer özellikler bulunan üniversitelerin, genel olarak
sosyal medya için bir strateji geliştirilmediği, mevcut medya araçları için geliştirilen mesajların sosyal medyaya
aktarıldığı ve üniversitelerin sosyal medyayı daha çok tanıtma için kullandığı görülmüştür.
Hipertrigliseridemiye bağlı akut pankreatit hastalarının acil serviste yönetimi
Authors: UZ İlhan , ÖZÇETE Enver , SONGÜR KODİK Meltem , ERSEL Murat , KİYAN Güçlü Selahattin
Published: October 2018

Amaç: Bu yazıda, hipertrigliseridemik akut pankreatit (HTGAP) tanısı alan hastalarda acil servis yönetimi ile ilgili deneyimlerimizi paylaşmayı amaçladık. Gereç ve Yöntem: Ekim 2015-Ekim 2016 tarihleri arasında, acil servisimize başvuran ve HTGAP tanısı alan hastaların lipaz, amilaz, trigliserid değerleri ve aldıkları tedavi rejimleri incelendi. Ortalama 1 gün/24 saat boyunca acil serviste takip edilen hastaların, klinik durumları ve başlangıç ile 24 saat sonraki trigliserid, amilaz, lipaz düzeyleri değerlendirmeye alındı. Bulgular: Çalışma süresi boyunca acil servisimize toplam 142.482 hasta başvurdu. Bu hastalardan akut pankreatit (AP) tanısı alan hasta sayısı 370’ ti. Bu hastalar içerisinde HTGAP tanılı 23-56 yaş aralığındaki 10 hastanın yaş ortalaması 36.2±19.8 olup 6' sı kadındı. Hastaların 7’ sinde hiperlipidemi, 6' sında diyabet, 2' sinde hipotroidi öyküsü vardı. Altı hasta daha önce pankreatit atağı geçirmişti. Hastaların hepsine, tanı anından itibaren acil serviste insülin infüzyon tedavisi başlandı. Ortalama 1 gün boyunca acil serviste takip edilen hastaların, klinik durumu ve 24 saat sonraki trigliserid, amilaz, lipaz düzeylerinin gerilediği görüldü. Sonuç: Acil serviste AP’ li hastalarda, etiyolojide hipertrigliseridemi akılda bulundurulmalıdır. HTGAP tanısı alan hastalarda komplikasyonları azaltmak için acil serviste erken tedavi başlanabilir ve insülin infüzyonu tedavisi, aferez tedavisine göre daha pratik ve takibi daha kolay olduğu için tüm hastalarda ilk seçenek olarak tercih edilebilir.
Aplicaciones del Captador Solar de Placa Plana y del Captador de Tubo de Vacío en la Edificación = Applications of the Flat Plate Solar Collectors and the Vacuum Tube Solar Collectors in Building
Authors: Ferrández Daniel , Moron Carlos , Díaz Jorge Pablo , Saiz Pablo
Published: October 2018

ResumenEl actual Código Técnico de la Edificación (CTE) pone de manifiesto la necesidad de cubrir parte de la demanda energética requerida para el abastecimiento de agua caliente sanitaria y climatización de piscinas cubiertas mediante sistemas de aprovechamiento de la energía solar térmica. En este artículo se presenta una comparativa entre las dos principales tipologías de captadores solares térmicos que existen en el mercado: el captador de placa plana y el captador de tubo de vacío, atendiendo a criterios de fracción solar, diseño e integración arquitectónica. Todo ello a fin de discernir en qué circunstancias es más favorable el uso de uno u otro sistema, comparando los resultados obtenidos mediante programas de simulación con la toma de medidas in situ.AbstractThe current Technical Building Code (CTE) highlights the need to cover part of the energy demand required for the supply of hot water and heating of indoor swimming pools using solar thermal systems. This article presents a comparison between the two main types of solar thermal collectors that exist in the market: the flat plate solar collector and the vacuum tube solar collector, according to criteria of solar fraction, design and architectural integration. All of this in order to discern in what circumstances the use of one or the other system is more favourable, comparing the results obtained through simulation programs with the taking of measurements in situ.
A Large Nuclear Gravitational Constant and its Universal Applications
Authors: U.V Satya Seshavatharam , Lakshminarayana S.
Published: October 2018

With reference to our earlier published views on large nuclear gravitational constant , nuclear elementary charge  and strong coupling constant , in this paper, we present simple relations for nuclear stability range, binding energy of isotopes and magic proton numbers.
Surface-Wave Extraction Based on Morphological Diversity of Seismic Events
Authors: Qiu Xinming , Wang Chao , Lu Jun , Wang Yun
Published: October 2018

Extraction of high-resolution surface waves is essential in surface-wave survey. Because reflections usually interfere with surface waves on X component in a multicomponent seismic exploration, it is difficult to extract dispersion curves of surface waves. The situation goes more serious when the frequencies and velocities of higher-mode surface waves are close to those of PS-waves. A method for surface-wave extraction is proposed based on the morphological differences between reflections and surface waves. Frequency-domain high-resolution linear Radon transform (LRT) and time-domain high-resolution hyperbolic Radon transform (HRT) are used to represent surface waves and reflections respectively. Then, the sparse representation problem based on the morphological component analysis (MCA) is built and optimally solved to obtain high-fidelity surface waves. An advantage of our method is its ability to extract surface waves when their frequencies and velocities are close to those of reflections. Furthermore, results of synthetic and field examples confirm that the proposed method can attenuate the distortion of surface-wave dispersive energy caused by reflections, which contributes to extracting accurate dispersion curves.
Solvents to Fragments to Drugs: MD Applications in Drug Design
Authors: Defelipe Lucas A. , Arcon Juan Pablo , Modenutti Carlos P. , Marti Marcelo A. , Turjanski Adrián G. , Barril Xavier
Published: October 2018

Molecular dynamics(MD) simulations are playing an increasingly important role in structure-based drug discovery (SBDD). Here we review the use of MD for proteins in aqueous solvation, organic/aqueous mixed solvents (MDmix) and with small ligands, to the classic SBDD problems: binding mode and binding free energy predictions. The simulation of proteins in their condensed state reveals the solvent structure and preferential interaction sites (hot spots) on the protein surface. This information is largely transferable across all classes of protein ligands (from water to drugs) and can be used very effectively to understand ligand recognition and improve the predictive capability of well-established methods such as molecular docking. MD simulations for protein and drug or drug-like compounds are now being used but are still computationally expensive and can only be applied to specific cases. On the other hand, MDmix simulations can now be used in SBDD and we will describe the latest developments and implementations. We expect to see an increase in the application of these techniques to a plethora of protein targets to identify new drug candidates with the advent of new tools and faster computers.
European Carbon Budget for Greenhouse Gasses Emissions: Filling the Trajectory Gap
Authors: Perissi Ilaria , Falsini Sara , Bardi Ugo , Natalini Davide , Green Michael , Jones Aled , Solé Jordi
Published: October 2018

The Global Carbon Budget is the cumulative carbon emissions that human activities can generate while limiting the global temperature increase to less than 2°C. On this basis, most countries ratified the Paris Agreement 2015, pledging to reduce national emissions and the impacts of climate change. The European Union has planned to reduce emissions by 80% of their 1990 value by 2050 but such a target needs to be coupled with a further constraint on the cumulative greenhouse gases released along the path to 2050. The aim and the novelty of this study are to propose, for the first time, a carbon budget for the European Union, which represents the most significant physical characteristic to assess the feasibility of current EU-28 greenhouse gas reduction objectives under the goals of the 2015 Paris treaty
Infrared Characterization of the Bidirectional Oxygen-Sensitive [Nife]-Hydrogenase from E. Coli
Authors: Senger Moritz , Laun Konstanin , Soboh Basem , Stripp Sven Timo
Published: October 2018

[NiFe]-hydrogenases are gas-processing metalloenzymes that catalyze the conversion of dihydrogen (H2) to protons and electrons in a broad range of microorganisms. Within the framework of green chemistry, the molecular proceedings of biological hydrogen turnover inspired the design of novel catalytic compounds for H2 generation. The bidirectional “O2-sensitive” [NiFe]-hydrogenase from Escherichia coli HYD-2 has recently been crystallized; however, a systematic infrared characterization in the presence of natural reactants is not available yet. In this study, we analyze HYD-2 from E. coli by in situ ATR FTIR spectroscopy under quantitative gas control. We provide an experimental assignment of all catalytically relevant redox intermediates alongside the O2- and CO-inhibited cofactor species. Furthermore, the reactivity and mutual competition between H2, O2, and CO was probed in real time, which lays the foundation for a comparison with other enzymes, e.g., “O2-tolerant” [NiFe]-hydrogenases. Surprisingly, only Ni-B was observed in the presence of O2 with no indications for the “unready” Ni-A state. The presented work proves the capabilities of in situ ATR FTIR spectroscopy as an efficient and powerful technique for the analysis of biological macromolecules and enzymatic small molecule catalysis.
PiBot: An Open Low-Cost Robotic Platform With Camera for STEM Education
Authors: Vega Julio , Cañas José M.
Published: October 2018

This paper presents the robotic platform, PiBot, that has been developed and that is aimed at improving the teaching of Robotics with vision to secondary students. Its computational core is the Raspberry Pi 3 controller board, and the greatest novelty of this prototype is the support developed for the powerful camera mounted on board, the PiCamera. An open software infrastructure written in Python language was implemented so that the student may use this camera, or even a WebCam, as the main sensor of this robotic platform. Also, higher level commands have been provided to enhance the learning outcome for beginners. In addition, a PiBot 3D printable model and the counterpart for the Gazebo simulator were also developed and fully supported. They are publicly available so that students and educational centers that do not have the physical robot or can not afford the costs of these, can nevertheless practice and learn or teach Robotics using these open platforms: DIY-PiBot and/or simulated-PiBot.
Accelerated Bioprocess Development of Endopolygalacturonase-Production with Saccharomyces cerevisiae Using Multivariate Prediction in a 48 Mini-Bioreactor Automated Platform
Authors: Sawatzki Annina , Hans Sebastian , Narayanan Harini , Haby Benjamin , Krausch Niels , Sokolov Michael , Neubauer Peter , Glauche Florian , Cruz Bournazou Mariano Nicolas
Published: October 2018

Mini-bioreactor systems enabling automatized operation of numerous parallel cultivations have been used to accelerate and optimize bioprocess development. As implementation of fed-batch conditions, multiple options of process control and sample analysis are possible, these systems represent valuable screening tools for large-scale production. However, the dynamic behavior of cultivations has not yet been considered regarding data evaluation and decision making during high-throughput screening in mini-bioreactors. In this study, the characterization of Saccharomyces cerevisiae AH22 secreting recombinant endopolygalacturonase is performed in 48 parallel fed-batch cultivations regarding 16 experimental conditions. Automated parallel process control, frequent sampling and analysis were implemented. Data-driven multivariate methods were developed to allow for fast, automated decision making as well as online predictive data analysis regarding endopolygalacturonase production. Using dynamic process information, a cultivation with abnormal behavior could be detected by principal component analysis as well as two clusters of similarly behaving cultivations, later classified according to the feeding rate. By decision tree analysis, cultivation conditions leading to an optimal recombinant product formation could be identified automatically. The developed method is easily adaptable and suitable for automatized process development reducing the experimental times and costs.
Ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Authors: Gonçalves Itamar Luís , Porto Kagami Luciano , Machado das Neves Gustavo , Rockenbach Liliana , Davi Leonardo , Soares Alceu Felipe , Garcia Solange Cristina , Eifler-Lima Vera Lucia
Published: October 2018

The Biginelli reaction is a highly versatile reaction, which leads to dihydropyrimidinones/thiones. This scaffold is reported as being a privileged structure due to its ability to interact with biological targets. Synthesis of ethyl 4-(2-fluorophenyl)-6-methyl-2-thioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate was achieved through the Biginelli reaction using a functionalized thiourea. In silico studies demonstrated that the compound title showed good potential for interacting with ecto-5’-nucleotidase, which has been considered as a target in designs for anti-cancer drugs.
Linkages of Soil Nutrients and Diazotrophic Microbiome under Sugarcane-Legume Intercropping
Authors: Solanki Manoj Kumar , Li Chang-Ning , Wang Fei-Yong , Wang Zhen , Lan Tao-Ju , Singh Rajesh Kumar , Singh Pratiksha , Yang Li-Tao , Li Yang-Rui
Published: October 2018

Intercropping significantly improves land use efficiency and soil fertility. This study examines the impact of three cultivation systems (monoculture sugarcane, peanut-sugarcane and soybean-sugarcane intercropping) on soil properties and diazotrophs. Sugarcane rhizosphere soil was sampled from the farmers’ field. Soil properties and nifH gene abundance were analyzed by high throughput sequencing. Moreover, a total of 436,458 nifH gene sequences were obtained and classified into the 3201 unique operational taxonomic units (OTUs). Maximum unique OTUs resulted with soybean-sugarcane intercropping (<375). The dominant groups across all cultivation were Alpha-proteobacteria and Beta-proteobacteria. On the basis of microbial community structure, intercropping systems were more diverse than monoculture sugarcane. In the genus level, Bradyrhizobium, Burkholderia, Pelomonas, and Sphingomonas were predominant in the intercropping systems. Moreover, diazotrophic bacterial communities of these cultivation systems were positively correlated to the soil pH and soil enzyme protease. Moreover, low available P recovered from intercropping system showed a strong correlation with higher nutrient uptake activity of soil microbes. Based on the results, our investigation concluded that intercropping system caused a positive effect on the growth of diazotrophic bacterial communities and it might boost the soil fertility and this kind of study helps to develop an eco-friendly technology for sustainable sugarcane production.
Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics
Authors: Biswas Tithi , Jindal Charulata , Fitzgerald Timothy , Efird Jimmy
Published: October 2018

The aim of this study was to examine pathologic complete response (pCR) and overall survival (OS) of patients diagnosed with non-metastatic inflammatory breast cancer (IBC). A total of N=8,550 cases undergoing surgery were identified between 2004-2013, using the National Cancer Database (NCDB). Patients were grouped into 4 biologic subtypes (HR+/HER2-, HR+/HER2+, HR-/HER2+, HR-/HER2-). The median age at diagnosis was 56 years. On average, women were followed for 3.7 years [interquartile range=3.0]. The majority were white (80%), had private health insurance (50%), and presented with poorly differentiated tumors (57%). Approximately 46% of the cancers were >5cm. Most patients underwent mastectomy (94%) and received radiotherapy (71%). Differences by biologic subtypes were observed for grade, lymph node invasion, race, and tumor size (p<.0001). Compared with non-pCR (54%), patients experiencing pCR had superior 5-year survival (77%) (p<.0001). Survival was poor for triple-negative (TN) tumors (37%) vs. other biologic subtypes (60%) (p<.0001). On multivariable analysis, TN-IBC, positive margins, and not receiving either chemotherapy, hormonal therapy or radiotherapy were independently associated with poor 5-year survival (p<.0001). In this large multicentric analysis of IBC, categorized by biologic subtypes, we observed significant differential tumor, patient and treatment characteristics, and OS.
Utilization and Balance in Channel Assignment for Rural Wireless Mesh Networks
Authors: Fang Chang , Feng Zhifang , Zuo Chao ,   School of Economics and Management, Anhui Normal University 189 Jiuhua South Road, Wuhu City, Anhui 241002, China,   School of Management, Hefei University of Technology No.193 Tunxi Street, Hefei 230009, China,   School of Management and E-Business, Zhejiang Gongshang University No.18 Xuezheng Street, Hangzhou 310018, China
Published: October 2018

Wireless mesh networks with directional antennas are expected to be a new promising technology and an economic approach for providing wireless broadband services in rural areas. In these networks, the effective use of multiple non-overlapping channels can significantly enhance the network capacity by allowing more concurrent transmissions. However, the performances of wireless mesh networks are severely degraded by interference between links with overlapping channels in nearby areas. In this paper, we address the issue of joint utilization and balance in channel assignment for rural wireless mesh networks. We design a new channel assignment framework with the goal of optimizing the channel resource utilization across the entire network while taking balanced allocation into account. This balanced channel assignment allows for the cost-effective reuse of channels without a consequent loss of quality in the rural wireless mesh networks. We also evaluate the proposed framework on some Cartesian product graphs that are popular interconnection network topologies. The framework guarantees that these topologies require a small number of channels for balanced allocation.