bluuebunny/crossref_metadata_2025 huggingface dataset:
Romanos y cartagineses después de la batalla. Costumbres funerarias y rituales de la Segunda Guerra Púnica en las fuentes literarias
Authors: Roselló Calafell Gabriel
Published: November 2023

El presente trabajo pretende realizar un análisis de las prácticas funerarias y rituales desarrolladas por cartagineses y romanos tras las batallas de la Guerra de Aníbal. Indagaremos con este propósito en el relato, a menudo estereotipado, de las fuentes literarias grecorromanas a propósito del tratamiento otorgado a los difuntos. También estudiaremos los mecanismos de obtención de spolia y sus diferentes usos. Nos preguntaremos, en definitiva, si podemos aislar ciertos patrones de comportamiento propios de época helenística y si la Segunda Guerra Púnica constituye un marco diferencial.
Analisis Kualitas Air Dan Perilaku Masyarakat Di Daerah Aliran Sungai (DAS) Kali Liliba Kota Kupang
Authors: Putra Ryan Sudrajat Permana
Published: November 2023

Daerah aliran sungai (DAS) Liliba merupaan salah satu sub DAS yang melewati Kota Kupang yang rentan dengan penurunan kualitas air yang disebabkan oleh aktivitas domestik, industri kecil dan pertanian. Penelitian ini bertujuan untuk menentukan kondisi eksisting fisik dan kimia perairan Kali Liliba dan menganalisis kualitas perairan Kali Liliba serta mengidentifikasi persepsi masyarakat di dalam mengelola Daerah Aliran Sungai Kali Liliba. Penelitian dilaksanakan dengan mengukur langsung beberapa parameter kualitas air seperti Fisik (Suhu, TSS, TDS), Kimia (pH, DO, COD BOD), Biologi (Fecal Coliform dan Total Coliform) dan mendistribusikan kuisioner kepada warga yang tinggal di sempadan sungai di Sub DAS Kali Liliba. Hasil penelitian menunjukkan bahwa pada parameter Total Coliform di Lokasi Jembatan Petuk (Stasiun 3) di sub DAS Liliba telah melebihi ambang batas yang ditetapkan sesuai dengan PP No.22 Tahun 2021. Parameter parameter Suhu, TDS, TSS, pH, Oksigen terlarut (DO), BOD, COD dan Fecal Coliform konsentrasi masing-masing parameternya masih dibawah baku mutu yang ditetapkan dalam PP No.22 Tahun 2021. Analisa status kualitas air dengan mengunakan STORET. Hasil analisis menunjukkan bahwa sub DAS Liliba dikategorikan tercemar ringan dengan skor -5. Sumber pencemar di  Daerah Aliran Sungai Liliba umumnya berasal dari sampah, limbah cair buangan baik dari septik maupun greywater, buangan limbah industri tahu, dan limbah pertanian dan peternakan. Hasil penelitian memperlihatkan bahwa 70,6% masyarakat langsung membuang limbah domestik ke sungai tanpa melewati proses pengolahan. Kata kunci: DAS Kali Liliba, Kualitas Air, STORET, Perilaku masyarakat
Edukasi Teknologi Pakan Untuk Meningkatkan Produktivitas Ternak Ruminansia Di Desa Pilangrejo, Nglipar, Gunung Kidul, D.I.Yogyakarta
Authors: Sudrajat Ajat , Christi Raden Febrianto
Published: November 2023

Feed technology is one of the best ways to improve the quality and extend the shelf life of feed. Feed consists of forage, legumes, concentrates and others. This service aims to provide knowledge about feed processing and preservation technology for ruminants in Pilangrejo Village, Nglipar, Gunung Kidul D.I.Yogyakarta. This service has been carried out and attended by 25 breeders. Implementation method by providing education and practice directly. The implementation stage begins with the distribution of pre-test questionnaires before the activity, the presentation of material on the introduction of feed technology, the distribution of post-test questionnaires to participants and ends with a question and answer session for participants and speakers. Furthermore, the introduction of feed in the form of forage such as odot grass, elephants, kings, rice straw, field grass and others that can be given with the potential availability in the area, The feed technology education provided is the technology of making feed silage. The results of the service show that knowledge of feed technology has increased at the farmer level based on post tests and direct practice, so it is hoped that with this education the people of Nglipar Village can process animal feed optimally and can be one of the solutions to feed shortages in the dry season.
Edição diplomática de Atrás do Pensamento: monólogo com a vida, de Clarice Lispector
Authors: Mai Tagiane
Published: November 2023

Apresentam-se a edição diplomática e os respetivos fac-símiles das primeiras dez páginas do datiloscrito “Atrás do pensamento: monólogo com a vida”, de Clarice Lispector, juntamente com a reprodução e edição diplomática da nota manuscrita “Calo-me”. Ambos os testemunhos integram o romance Água viva, publicado em 1973. O material é parcialmente inédito e encontra-se disponível para consulta apenas presencial na sede do Instituto Moreira Salles, no Rio de Janeiro, mediante agendamento. As reproduções e edições diplomáticas ora apresentadas foram autorizadas pelo herdeiro e detentor dos direitos de publicação da autora. Pretende-se, com esta fonte primária, subsidiar novas análises e interpretações da referida obra, bem como abrir caminho para que outros pesquisadores se debrucem sobre a integralidade do documento e contribuam para a fortuna crítica clariciana.
konstruera begåvning
Authors: Axelsson Thom
Published: November 2023

Throughout the 20th century, the nature of intelligence has been a hot topic and an intensely debated issue. It is the measuring and testing of intelligence, in particular, that has aroused the strongest reactions from defenders and protesters alike. The discussion on intelligence tests have frequently revolved around questions such as whether these tests will lead to an increased social mobility and liberation or, on the contrary, to exclusion and discrimination of certain groups. The focus of the present article, however, is not the consequences of intelligence testing but rather the debate concerning the testing within the research community. This debate is approached from three different perspectives: a historical perspective, a psychological perspective, and a perspective allowed for by discourse analysis. Having done this, I discuss one other tentative way of dealing with intelligence testing that does not necessarily have to involve narratives of liberation or of oppression. This is done with the help of Michel Foucault’s concept ‘governmentality’.
Bibliometric Analysis: Remote Sensing Applied to Urban Permanent Preservation Areas
Authors: De Souza Petersson Cardoso , Ribeiro Vinícius de Oliveira , Corrêa Nelison Ferreira , Carvalho Pamela Alves
Published: November 2023

Objective: To carry out a Bibliometric Analysis to quantify and evaluate academic publications on Permanent Preservation Areas (PPAs) in urban contexts, with an emphasis on the use of Remote Sensing.
 
Theoretical framework: This work is based on a bibliometric analysis of Permanent Preservation Areas (PPAs) in urban contexts, with an emphasis on the use of Remote Sensing, and their importance in preserving natural resources, highlighting the need to collect accurate and up-to-date data to support technical studies and public policies.
 
Method: Vosviewer software was used to build bibliometric networks, interactive visualizations and text mining. In addition, the SNA (Social Network Analysis) methodology was applied to examine the relationships between authors, countries and institutions, and VOSviewer was used as the main tool to map and evaluate these connections. Data was collected from the Web of Science database.
 
Results and conclusion: The results covered 525 publications on PPAs and Remote Sensing, where bibliometric analysis highlighted a significant increase in academic interest from 2055 onwards. Brazil leads in publications in the area, with emphasis on the University of São Paulo (USP) and international collaboration. In addition, authors such as Alexandre Rosa dos Santos and Jose Eduardo Macedo Pazzopone are influential in the field.
 
Research implications: The research reveals significant trends in academic production on Permanent Preservation Areas (PPAs) and Remote Sensing in urban contexts. Key findings include the remarkable growth in interest in this topic, reflecting a growing environmental awareness. These findings have implications for managers, researchers, professionals and policymakers aiming at environmental preservation and the promotion of collaborative research.
 
Originality/value: Through the methodology adopted, the study identified emerging trends and highlighted the growing global interest in this theme, reflecting growing environmental awareness and legislative changes. The implications of these findings are significant, not only for researchers, but also for managers, policymakers and practitioners, offering valuable insights for the promotion of more sustainable practices and environmental awareness.
Safety of Nicarbazin in Raptors in Relation to Pigeon Eradication Programs
Authors:   Veterinary pharmacology and toxicology, Department of Veterinary Sciences, University of Pisa, Italy, Marchi Lucia De
Published: November 2023

he anticoccidial drug nicarbazin, mixed at a concentration of 800 mg/kg with corn kernels, is marked as Ovistop® and R-12® for the fertility control of pigeons. Nicarbazin is considered “practically non-toxic” when fed to birds and mammals, and the only potential adverse effect in non-target birds is a reduction in egg hatchability.
لادانا کارى د گوتنێن مەزناندا ل دویڤ تیۆرا بەرهەمهینان وڤەگوهازتنێ پەرتووکا (گوتنێت پێشینان ل دەڤەرا بادینان) وەک نموونە
Authors: Nageeb Muhammad Amin Bayar , Omer Ahmed Bahiez
Published: November 2023

لادان ئێک ژ یاسایێن ڤەگوهازتنێ یێن تیۆرا بەرهەمهینان و ڤەگوهازتنێ یا زانایێ ئەمریکى (ئەفرام نعوم چۆمسکى)یە و د ئەڤێ ڤەکۆلینێدا هەول هاتییە دان لادانا کارى د ناڤ گوتنێن مەزناندا بهێتە بەحسکرن. ئەڤ ڤەکۆلینە ب ناڤێ (لادانا کارى د گوتنێن مەزناندا ل دویڤ تیۆرا بەرهەمهینان و ڤەگوهازتنێ پەرتووکا (گوتنێت پێشینان ل دەڤەرا بادینان) وەک نموونە)یە، کو تێدا هەول هاتییە دان ئەگەر و مەبەست و جۆرێن لادانا کارى د ناڤ گوتنێن مەزناندا ل گەل ڕێژەیا سەدى یا هەر ئێک ژ ئەوان جۆران بهێتە دیارکرن. ئەڤ ڤەکۆلینە ژ دوو پشکان پێکدهێت، پشکا ئێکێ بۆ تیۆرا بەرهەمهینان و ڤەگوهازتنێ هاتییە تەرخانکرن و د پشکا دووێدا بەحس ل لادانا کارى د گوتنێن مەزناندا هاتییە کرن و ل دووماهییا ڤەکۆلینێ بۆ مە دیاربوو، کو پتر کار د گوتنێن مەزنان یێن نەسادەدا ژ گوتنێن مەزنان یێن سادە هاتییە لادان و ئەڤ چەندەژى ژبۆ مەبەستێن: کورت بڕى، کێش و سەروا، دووبارەنەبوونێ هاتییە ئەنجامدان.
An Exploration of Ethics-Based Leadership in Human Resource Management at Institutions of Early Childhood Education
Authors: Ade Wawan
Published: November 2023

This research aims to investigate the role of ethics-based leadership in human resource management within early childhood education of Ma'arif institutions Lampung. The study explores how ethical principles in leadership influence human resource management, the quality of educational services, and child development in these institutions. The research methodology employed involves interviews, observations, and document analysis. The results of this study are expected to provide deeper insights into the significance of ethics in leadership within early childhood education institutions and its contribution to holistic child development. This research holds practical implications for enhancing the quality of early childhood education through an ethically grounded human resource management approach
Literacy in Early Childhood with Hearing Loss: Challenges and Strategies in Education
Authors: Nur Latifah  , S. Sumihatul Ummah MS  , Petrus Jacob Pattiasina  , Ida Bagus Made Wisnu Parta  , Supriyanti
Published: November 2023

This research analyzes literacy development in children with hearing loss, focusing on the challenges faced and strategies used in the educational context. Literacy plays a vital role in learning and social integration, yet children with hearing loss may face barriers in developing these skills. Through interviews with notable education experts, parents and teachers, this study identifies specific literacy development patterns and uncovers the challenges faced. The results of this study are expected to provide a better understanding of literacy development in children with hearing loss and provide insights into the challenges and effective educational strategies. The implications of this study can contribute to the development of better inclusive curricula and the provision of appropriate support for children with hearing loss in developing their literacy skills.
Child-Led Decision Making Process to Assorting Children Voice in Bandung District
Authors: Aisha Emeralda
Published: November 2023

The research will discuss child participation in the decision-making process, the leadership led by children is essential to be discussed because children often seen as a human who have not capacity to make decisions or always influenced by an adult. Through this research we will seen how children take the decisions using participation in decision-making (PDM) which are upward and downward information flow. The novelty of this research is how children are given the authority to take the decisions. This research are using qualitative research by having FGD with the child members in children's forum and secondary data from literature reviews. As a result of this research,  children using upward information flow to compile children's voices and downward information flow as a part of the cognitive model in decision-making process. The participation of children will not be meaningful if an adult that accompany the children was not trained and professional adult as it was mentioned in this research on how adult able to hinder children voice because of her lack of capacity. In implementing meaningful participation in the decision-making process, it is important for children to have the right access of the right information.
The Analysis of Utilizing Pinterest Application in Making Interactive Teaching-Learning Media for Early Childhood Students
Authors: Puspitasari Tuti , Riyanto  , Tubagus Munir , Aziz Firman , Dewi Christine Sientta
Published: November 2023

This research aimed to discover the use of virtual pinboard applications in making learning media for early childhood. The method used is a qualitative research approach. The subjects to be studied were teachers who had used the virtual pinboard application to find inspiration in making media, totaling 10 teachers. Data collection techniques in this study were observation, documentation, and interviews using previously validated instruments. The results of the study show that by using virtual pinboard applications to inspire teachers, teachers can increase early childhood student enthusiasm for the learning process. The ideas that the teacher found while using the virtual pinboard application, in addition to being original, combine ideas that are triggered as a source of information to be adapted and adjusted to the teacher's abilities and existing resources to support teaching and learning activities in the classroom.
Art Therapy through Doodle Art Media in Increasing Learning Concentration Children with ADHD
Authors: Mahardika Bagus , Andi Purnawan Putra Andi
Published: November 2023

The importance of guiding students in increasing their concentration in learning is the task of an educator. Learning can be digested well when students have adequate concentration and absorption in paying attention to the teacher when explaining the material in front of the class. However, this is certainly different from children with disabilities who require a special approach to be able to receive learning material well. This research aims to see the effectiveness of art therapy using doodle art as a medium, which is expected to improve the concentration of children with ADHD. The research method uses qualitative with a case study approach, to see how the implementation of art therapy improves children's learning concentration. The results of the research show that art therapy with doodle art is able to increase concentration in children with ADHD in the memory aspect, attitude aspect and skill aspect. This approach is chosen according to the conditions and needs of the child, freeing the child to express himself in the doodle art media. It is very effective to see the attitude and enthusiasm of the students during the learning process, they really enjoy it and can relate well to the experiences gained during the learning activities.
Perfil epidemiológico das gestantes de alto risco no Amazonas: uma investigação de 2021 a 2022
Authors: Rosa Sabryna Maria Lopes Gonçalves , Martins Adelaide Gomes
Published: November 2023

Objetivo: Analisar o perfil epidemiológico das gestantes de alto risco nos atendimentos ambulatoriais do Amazonas no período de 2021 a 2022, utilizando dados coletados via DATASUS. Métodos: Trata-se de um estudo retrospectivo, quantitativo, do tipo ecológico cuja coleta de dados foi realizada por meio do SIH/DATASUS (Sistema de Informações Hospitalares/Departamento de Informática do Sistema Único de Saúde) de recorte temporal de 2021 e 2022. Resultados: Trata-se de um estudo retrospectivo, quantitativo, do tipo ecológico cuja coleta de dados foi realizada por meio do SIH/DATASUS (Sistema de Informações Hospitalares/Departamento de Informática do Sistema Único de Saúde) de recorte temporal de 2021 e 2022. Portanto, o aumento de atendimentos a gestantes de alto risco no Amazonas destaca a importância do cuidado especializado na gravidez. Conclusão: Identificar riscos, analisar perfis e tratar doenças são fundamentais para reduzir complicações, além do que, estratégias preventivas e acompanhamento personalizado são essenciais para o bem-estar materno e fetal, garantindo melhores resultados de saúde.
Soroprevalência das Hepatites B e C em pacientes em hemodiálise em Centro de Referência Estadual, Belém, Pará, Brasil
Authors: Miranda José Vitor da Silva , Pereira Lorena Alves , Lima Sandra Souza , Freitas Pedro Eduardo Bonfim , Vallinoto Izaura Maria Vieira Cayres
Published: November 2023

Objetivo: Caracterizar o perfil clínico-epidemiológico e soroprevalência dos pacientes atendidos em centro de referência em hemodiálise em Belém-PA, em janeiro de 2022. Métodos: Trata-se de estudo transversal de prevalência, com 116 pacientes de ambos os sexos, de 18 a 81 anos. Coleta de dados por levantamento de dados de prontuários, foram investigados o perfil clínico-epidemiológico e a soroprevalência para hepatites virais B e C. Resultados: Dos 116 pacientes, 60,34% eram homens e 32,76% pertencem à faixa etária de 48 - 62 anos completos, 44,82% tiveram o tempo de hemodiálise > 60 meses. As principais etiologias causadoras da falência renal: nefroesclerose hipertensiva (23,27%) e nefropatia diabética (18,10%). Soroprevalência: anti-HBs reagente (75,00%), anti-HBc total não reagente (83,03%), HBsAg não reagente (100%) e anti-HCV não reagente (95,49%). Excluindo os vacinados, houve associação significativa entre a imunização natural pelo vírus da Hepatite B e o tempo de hemodiálise superior a 60 meses. Conclusão: Foi observado maior prevalência de anti-HBs reagente, anti-HBc total não reagente, HBsAg não reagente. Quanto a Hepatite C, há maior frequência de anti-HCV não reagente. Ademais, será necessária a progressão do estudo com testes de biologia molecular, para melhor avaliação da prevalência da infecção por Hepatites B e C.
Remarques sur le vocabulaire idéologique de Jakobson
Authors: Toman Jindrich
Published: November 2023

[pas de résumé]
Italian Odessa: The Second Homeland of Ambrogio Dagnini, Tenor from Mantova
Authors: Козлова Л.А.
Published: November 2023

Благодаря взлету традиции бельканто в первой половине XIX в. итальянская опера молниеносно завоевала сцены европейских театров. Одессу новая мода завоевала раньше, чем Санкт-Петербург и Москву. Именно в этом городе активно работали многие известные итальянские музыканты. Среди них чрезвычайно привлекательна история старинного мантуанского рода Данини, представители которого впоследствии внесли заметный вклад в развитие отечественных науки и искусства. Основоположник российской ветви семейства тенор Амброджио Данини, приехав в 1840 г. на гастроли в Одессу, обрел в России вторую родину. В статье рассматриваются особенности одесской музыкальной культуры и изменения в ней, произошедшие благодаря деятельности мантуанского певца.

Italian opera quickly conquered the scenes of European theaters, due to the rise of the Italian bel canto style in the first half of the 19th century. The new fashion came to Odessa earlier than to St. Petersburg and Moscow. Particularly interesting are the turns in the fate of the Italians who remained in Russia and served for the good of their new Fatherland. Among them is the history of the ancient Mantova family of Dagnini, who subsequently made a significant contribution to the development of domestic science and art. Arriving in 1840 on tour in Odessa, tenor Ambrogio Dagnini, who started the Russian branch of the family, found here his second homeland in Russia. The article studies specifics of the development of the cultural environment in Odessa and changes therein due to the work and art of the singer and his significant influence on the local opera house.
Birth of the German Romantic Organ
Authors: Глазкова Ю.В.
Published: November 2023

В статье рассматриваются основные этапы становления уникального феномена в истории мировой органной культуры — немецкого романтического (симфонического) органа. Предпосылки его появления связаны со спецификой развития симфонического оркестра в первой половине XIX в., а также с эстетическими и звуковыми поисками органистов и органостроителей начиная с середины XVIII в. — когда и те, и другие пришли к мысли о необходимости усиления и расширения среднего диапазона органного звучания. Основной вклад в развитие этих тенденций внесли органные мастера центральной Германии: Готфрид Зильберман, Цахариас Хильдебрандт, южнонемецкий мастер Йозеф Габлер, а также Иоганн Себастьян Бах — в качестве органного эксперта. Большая роль в становлении немецкого романтического органа принадлежит также аббату Фоглеру, который первым сформулировал идею о том, что орган должен подражать звучанию оркестра, и с целью ее воплощения создал свою «упрощенную» систему, согласно которой были построены несколько инструментов, оказавших влияние на дальнейшее развитие органостроения в Германии. В статье рассмотрены тембровые и динамические характеристики инструмента, который часто называют первым немецким романтическим органом, — органа Ф. Валькера в церкви Св. Павла во Франкфурте.

The article discusses the history of development of one of the most unique phenomena in the history of world organ culture — the German romantic (symphonic) organ. The prerequisites for its appearance are in the evolution of the symphony orchestra in the first half of the 19th century, as well as in the aesthetic and sonoristic searches of organists and organ builders, starting from the middle of the 18th century — when both of them gradually come to the idea of a need in strengthening and expanding the average range of  organ sound. The main contribution to these trends was made by the organ masters of the central Germany: Gottfried Silbermann, Zacharias Hildebrandt, the South German master Josef Gabler, and Johann Sebastian Bach as an organ expert. A large role in the development of the German romantic organ also belongs to Abbé Vogler, who was the first to formulate the idea that the organ should imitate the sound of the orchestra, and in order to implement this idea, he created his own “simplified” system, according to which several instruments were built that influenced the further development of organ building in Germany.The article specifically considers the timbre-dynamic characteristics of the instrument, which is often called the first German romantic organ — the organ of F. Walker in St. Paul’s Church in Frankfurt.
Proaritmiás gyógyszermellékhatások vizsgálata transzgenikus hosszú QT-szindrómás nyúlmodellek segítségével
Authors: Hornyik Tibor , Husti Zoltán , Baczkó István
Published: November 2023

A gyógyszer okozta ritmuszavar a különböző vegyületek súlyos és potenciálisan halálos mellékhatása. A proaritmiás mellékhatást gyakran az adott gyógyszernek a szívizom-repolarizáló ionáramait gátló hatásaival hozzák összefüggésbe, ami az EKG-n a QT-intervallum meghosszabbodásához vezet. A gyógyszerfejlesztésben alkalmazott kifinomult szűrési módszerek ellenére a proaritmia megbízható előrejelzése továbbra is jelentős kihívást jelent. Bár a gyógyszerek által kiváltott QT-idő megnyúlással összefüggő proaritmiás hatás iránt fokozottan érzékenyítenek a betegek repolarizációs tartalékát csökkentő kórfolyamatok, a legtöbb gyógyszerbiztonsági szűrésre használt modellrendszer normális, egészséges sejteket, szöveteket és állatokat használ fel. A közelmúltban több, csökkent repolarizációs tartalékkal rendelkező transzgenikus hosszú QT-szindrómás (LQTS) nyúlmodellt hoztak létre. Összefoglaló közleményünkben e modellek lehetséges felhasználását tárgyaljuk a gyógyszerindukált aritmiák előrejelzésére, összefüggésben a különböző modellekben tapasztalt repolarizáló szívizom ionáram-károsodással. Emellett áttekintjük a rendelkezésre álló transzgenikus LQTS-nyúlmodellek elektrofiziológiai jellemzőit, a modelleken végzett farmakológiai elvi bizonyító vizsgálatokat, kiemelve a transzgenikus nyúl LQTS-modellek előnyeit és hátrányait a gyógyszerindukálta ritmuszavar kutatásában.
Hidden Boron Catalysis: A Simple Colourimetric Indicator
Authors: Macleod Julie , Thomas Stephen
Published: November 2023

‘Hidden’ catalysis plagues the development and understanding of all catalytic processes. Hidden acid catalysis and catalysis by trace metal contamination being two widely recognised examples. Since 2010, over 600 new catalysed hydroboration protocols have been reported despite the prevalence of hidden borane catalysis across hydroboration reactions using HBcat and HBpin. Nucleophilic species, present as either activators, additives or inherent to the catalyst structure, readily mediate the decomposition of HBpin and HBcat to boranes, including (ligated) BH3. These boranes are themselves catalysts for alkene and alkyne hydroboration, so often serve as the active, ‘hidden’, catalyst rather than the intended metal/metalloid species reported as a the ‘catalyst’. Following our introduction of the TMEDA test for hidden borane catalysis 2020, the proportion of catalysed hydroboration publications testing for hidden borane catalysis has increased from 5% to 23%, but this is still well short of routine. We now report, a simple, rapid and colourimetric method for the determination of hidden borane catalysis. This method uses nothing more than a colour change visible to the naked eye, akin to litmus paper acid/base indicators. The colourimetric test uses a bench-stable, widely commercially-available reagent, crystal violet, at low concentration to identify hidden borane catalysis in seconds. in situ BH3 formation from the decomposition of HBpin by species from across the periodic table has been positively identifed using this new test. The colourimetric indicator does inhibit the hydroboration reaction and shows no reactivity with substrates, HBpin, HBcat, nucleophilic species or any of the ‘catalysts’ tested. This test is easily applied to all past and future catalysed hydroboration reactions and represents the first example of a colour indicator for hidden catalysis.
Enantioselective Synthesis of Amino Acids by Photocatalytic Reduction of CO2 on Chiral Mesostructured ZnS
Authors: Cui Yongping , Ai Jing , Li Yuanbo , Han Lu , Duan Yingying , Liu Junhong , Liu Xi , Chen Liwei , Jia Menghui , Chen Jinquan , Chu Chaoyang , Ma Yanhang , Ouyang Tianwei , Che Shunai , Fang Yuxi
Published: November 2023

Reduction and fixation of CO2 in natural systems via solar energy generates diverse products, ranging from small molecules to biomolecules. To date, only a few multicarbon species have been obtained by artificial CO2 photoreduction1-5, especially abiotic photosynthesis of biomolecules with various functional groups, which has long been a fundamental yet challenging issue. Herein, we report the photocatalytic synthesis of amino acids from CO2 and NH3 on a chiral mesostructured ZnS (CMZ) nanosphere, which is constructed by arrays of chiral nanorods. Serine (Ser) is the main component of various amino acids, with an enantiomeric excess (ee) greater than 96% and a total yield of over 30 μmol gcat-1. The Ser formation pathway could be accessed through *OCCO intermediates due to C-C coupling, as demonstrated by experimental data. Chiral-induced spin polarization of CMZ has been speculated to facilitate the separation of photogenerated carriers and the production of stable triplet OCCO. Different activation energies of reduction reactions driven by the spin-polarized electrons in CMZ lead to the formation of enantiomeric amino acids. Our findings will inspire new perspectives in catalytic theory and the formation of chiral biomolecules in artificial synthesis and nature.
Diabetes mellitus type 2: National Russian guidelines vs real clinical practice
Authors: Shestakova Marina V. , Vikulova Olga K. , Zheleznyakova Anna V. , Dedov Ivan I. , Mokrysheva Natalia G.
Published: November 2023

According to the “Federal Law on the Fundamentals of Protection of the Public Health”, medical care for patients should be provided in accordance with National Russian guidelines for the relevant nosology, which are based on the principles of evidence-based medicine. The article presents an analysis of the compliance with the completeness of implementation of National Russian guidelines in the treatment of patients with type 2 diabetes mellitus (DM 2) in real clinical practice. The analysis of the actual state of management of DM 2 patients was carried out from the Federal Register of diabetes as of 01.01.2023. Incomplete compliance with the guidelines on the frequency of measuring glycated hemoglobin, the rate of intensification of hypoglycemic therapy, and the appointment of new classes of hypoglycemic drugs was established. Possible reasons for the identified discrepancies between real practice and guidelines requirements are discussed, as well as possible measures to overcome these discrepancies.
Advantages of glucagon-like peptide-1 receptor agonists in the treatment of patients with type 2 diabetes mellitus: A review
Authors: Demidova Tatiana Y. , Titova Victoria V. , Izmaylova Maryam Y.
Published: November 2023

Glucagon-like peptide-1 receptor agonists (arGLP1) are an effective treatment for patients with type 2 diabetes mellitus (T2DM), mainly due to increasing insulin secretion and suppressing glucagon release by stimulating the respective receptors. Taking into account their positive effect on major cardiovascular events, drugs in this group with proven cardioprotective effects are recommended for patients with T2DM and clinical cardiovascular diseases or multiple cardiovascular risk factors. In this paper, we present an overview of current clinical studies on the clinical efficacy and safety of arGLP1 and discuss current prospects for arGLP1 as a therapy for patients with T2DM.
Ala54Thr polymorphism of the fatty acid transporter gene (FABP2) in patients with type 2 diabetes mellitus in Yakutia
Authors: Sydykova Liubov A. , Pavlova Nadezhda I. , Bochurov Alexey A. , Alekseev Vladislav A. , Krylov Alexey V. , Kurtanov Khariton A. , Shestakova Marina V.
Published: November 2023

Aim. To study the contribution of the Ala54Thr genetic polymorphism of the FABP2 gene to the risk of developing type 2 diabetes mellitus among the Yakut population.
Materials and methods. The study included participants who filled out a questionnaire approved by the Local Committee on Biomedical Ethics at the Yakut Science Centre of complex medical problems and voluntarily signed an informed consent to conduct a genetic study. The sample consisted of 181 patients of the endocrinological department of the Republican Hospital No. 2 of the State Budgetary Institution “Center for Emergency Medical Care“ with a diagnosis of type 2 diabetes. The comparison group was a sample of 336 volunteers without chronic diseases of the Yakut ethnicity. For molecular genetic analysis, genomic DNA samples were isolated from whole blood. Single nucleotide polymorphism was determined by polymerase chain reaction followed by analysis of restriction fragment length polymorphism.
Results. Study showed that polymorphism in the FABP2 gene has an impact on anthropometric parameters and blood biochemical parameters. The risk of developing type 2 diabetes was 1.7 times higher in carriers of the Ala/Thr genotype (odds ratio 1.755, 95% confidence interval – 1.212–2.542; p0.005) compared with carriers of other genotypes. When comparing the average biochemical values, the levels of aspartate transaminase, alanine aminotransferase, glucose and total bilirubin in homozygous carriers of the Ala/Ala genotype were significantly lower than in carriers of other genotypes (р0.05). Carriers of the heterozygous Ala/Thr genotype (р0.05) had the highest level in terms of aspartate aminotransferase and alanine aminotransferase. The highest indicator of the average level of HbA1c and an indicator of total bilirubin were carriers of the Thr/Thr genotype (р0.05).
Conclusion. The high prevalence of the negative Thr allele among the Yakut population is probably associated with living conditions in the North, as well as in the traditional type of diet.
Neurological manifestations of hypoparathyroidism: diagnostic difficulties. Case report
Authors: Nuzhnyi Evgenii P. , Antonova Ksenia V. , Tanashyan Marine M. , Illarioshkin Sergey N.
Published: November 2023

Hypoparathyroidism is a rare condition characterized by reduced production of parathyroid hormone or tissue resistance which leads to hypocalcemia and hyperphosphatemia. Neurological manifestations often occur as the first symptoms of hypoparathyroidism and are characterized by a wide variety of symptoms of both the central and peripheral nervous systems dysfunction, which requires a differential diagnosis with a wide range of neurological diseases. Two clinical cases illustrating the features of subacute and chronic hypoparathyroidism are presented. In the case of subacute hypoparathyroidism, a young woman presented with severe tetany involving the oculomotor muscles (paroxysmal strabismus), laryngeal muscles (respiratory stridor), body muscles (opisthotonus, «obstetrician's hand») and the development of secondary myopathy. In another case with a long-term chronic course of postoperative hypoparathyroidism, the patient's adaptation to severe hypocalcemia was noted; the clinical features were dominated by cerebral syndromes due to brain structures calcification (Fahr's syndrome). Possible reasons for late diagnosis of hypoparathyroidism, the importance of active detection of symptoms of neuromuscular hyperexcitability and laboratory testing of phosphorus and calcium metabolism are discussed.
Non-alcoholic fatty liver disease: aspects of management of a comorbid patient. A review
Authors: Demidova Tatiana Y. , Ushanova Fatima O.
Published: November 2023

Against the background of the rapid increase in the prevalence of obesity worldwide, the frequency of the development of metabolic disorders associated with it is increasing. Non-alcoholic fatty liver disease (NAFLD) is recognized as the main hepatic manifestation of metabolic syndrome. Currently, NAFLD affects about 25–30% of the world's population and, in most cases, is associated with obesity and type 2 diabetes, as well as with increased cardiovascular risk. Diagnosis of NAFLD includes laboratory and instrumental research methods, various non-invasive tests, and the “gold standard” for confirming the diagnosis is a liver biopsy. Due to the greater availability and sufficient information content, ultrasound methods of research come to the fore in the examination of patients at risk. Lifestyle modification remains the cornerstone in the management of such patients, however, given the complex pathogenesis of the disease, treatment of NAFLD may include several therapeutic strategies. In the treatment of comorbid patients, some groups of hypoglycemic drugs are used, including ar-GLP-1, i-NGL-2, pioglitazone, lipid-lowering drugs, drugs for the treatment of obesity. The so-called hepatoprotectors, including essential phospholipids (EFL), have demonstrated their effectiveness in reducing liver damage due to antioxidant, antifibrotic, and lipid-regulating effects. According to a number of studies, EFL helps to reduce the severity of steatosis, improving both objective and subjective manifestations of hepatic dysfunction. In this connection, the guidelines of various countries include EFL group drugs in the protocol of treatment of patients with NAFLD both in monotherapy and in combination with other drugs.
Efficacy and safety of bacterial lysate OM-85 in the treatment of uncomplicated acute respiratory infections: a double-blind, placebo-controlled, multicenter, randomized trial
Authors: Kalyuzhin Oleg V. , Gorelov Aleksandr V. , Malyavin Andrey G. , Zaytsev Andrey A. , Esaulenko Elena V. , Novak Ksenia E. , Bykov Anatoliy S.
Published: November 2023

Aim. To evaluate the efficacy and safety of OM-85 in the treatment of uncomplicated acute respiratory infections (ARI) in adults.
Materials and methods. A double-blind, placebo-controlled, multicenter, randomized trial included 556 patients (18–60 years old) with mild and moderate ARI and negative results of polymerase chain reaction analysis for SARS-CoV-2 RNA and rapid test for influenza A and B viruses. Patients were randomized into two groups: in the first group (n=278), patients received OM-85 (Broncho-munal®) one capsule 7 mg/day for 10 days, while the second group (n=278) was treated with placebo in the same regimen. The primary endpoint was the dynamics of the severity of symptoms over 3, 5, 7 and 10 days of treatment according to the 21-item Wisconsin Upper Respiratory Symptom Survey (WURSS-21), which was assessed by the area under the curve. Secondary efficacy criteria were the dynamics of the severity of symptoms according to the Common Cold Questionnaire (CCQ), the time to the resolution of symptoms according to WURSS-21 and CCQ, the proportion of patients with body temperature below 37°C on each day of treatment, frequency of the need for systemic antibacterial therapy.
Results. The superiority of OM-85 over placebo by primary endpoint was observed on the 5th, 7th and 10th days of treatment. OM-85 efficacy has also been proven by secondary criteria. OM-85 shortened the time until the symptoms of ARI resolved according to the WURSS-21 and CCQ, increased the proportion of patients with body temperature below 37°C by 2–9 days. The time needed to resolve the symptoms of disease in 20% of patients according to WURSS-21 was 7 and 9 days in patients taking OM-85 and placebo, respectively. Bacterial lysate increased the probability of complete disappearance of symptoms according to CCQ by 45.7% compared to placebo. The analysis of the frequency and severity of adverse events, laboratory tests, physical and instrumental examination results during treatment confirmed the good tolerability and safety of OM-85.
Conclusion. The study confirmed the efficacy and safety of OM-85 in the complex treatment of ARI in adults.
Autoimmune polyendocrine syndrome in adults. Focus on rheumatological aspects of the problem: A review
Authors: Panevin Taras S. , Zotkin Evgeniy G. , Troshina Ekaterina A.
Published: November 2023

Autoimmune polyglandular syndromes (APS) are a heterogeneous group of clinical conditions characterized by functional impairment of multiple endocrine glands due to loss of central or peripheral immune tolerance. These syndromes are also often accompanied by autoimmune damage to non-endocrine organs. Taking into account the wide range of components and variants of the disease, APS is usually divided into a rare juvenile type (APS 1) and a more common adult type (APS 2–4). APS type 1 is caused by a monogenic mutation, while APS types 2–4 have a polygenic mode of inheritance. One subtype of adult APS (APS 3D) is characterized by a combination of autoimmune thyroid disease and autoimmune rheumatic disease. This review considers the available literature data on combinations that meet the above criteria. Many studies have noted a significantly higher prevalence of rheumatic diseases in patients with autoimmune thyroid disease compared with the control group. Also, as in a number of rheumatic diseases, a more frequent occurrence of autoimmune thyroiditis, primary hypothyroidism and Graves' disease was noted.
Analysis of the Relationship Between Returns of Nasdaq Composite and Bitcoin
Authors: Hasanov Ali
Published: November 2023

Purpose:  The article aims to investigate the relationship between the returns of the NASDAQ Composite stock index and the Bitcoin cryptocurrency.
 
Theoretical framework: According to the literature, it is obvious that cryptocurrencies are very volatile, especially during the economic instability period. There is a belief that when uncertainty is in the economy, investors prefer alternative investment opportunities. There is a need to prove that.
 
Design/Methodology/Approach: The study employs two different models, the ARMAX and the GARCH, to analyze the data from March 2018 to March 2023. The results of the analysis suggest a significant relationship between the returns of the NASDAQ Composite and Bitcoin. These results have important implications for investors and policymakers.
 
Findings:  The findings suggest that investors need to be aware of the potential risks and benefits associated with investing in both assets, particularly in times of economic uncertainty. Policymakers may also need to consider the impact of traditional stock markets and the overall economy on cryptocurrencies.
 
Research, Practical & Social implications: The research suggests that investors should be careful with cryptocurrencies.
 
Originality/Value: The results are based on the time series analysis that makes the research original. Because there are few examples of time series and volatility analysis of cryptocurrencies.
An Artificial Intelligence Agenda for New Zealand
Authors: Mulopulos Sam
Published: November 2023

With recent advances in artificial intelligence (AI), policymakers are looking for tools to promote the associated benefits, as well as mitigate the attendant risks. Thanks to extensive experimentation by international partners, New Zealand is positioned to parse the lessons of those international policies and more quickly adapt those that are successful to its own context. This article identifies several key AI policies pursued by the United States that may be relevant in a New Zealand context and discusses broad lessons from the US experience to help inform successful AI policymaking in New Zealand. It also emphasises the unique bipartisan nature of AI policymaking in the United States to date, and the benefits of a consensus-building approach to AI policy.
MENINGKATKAN KREATIVITAS SISWA DALAM MEMANFAATKAN LIMBAH ALUMINIUM UNTUK KRIYA LOGAM DI SMA NEGERI 1 PANYABUNGAN UTARA
Authors: Firiyansyah Syahril , Amrizal Amrizal , Nova Siska Mitria
Published: November 2023

This research was conducted to increase students' creativity in utilizing aluminum waste for metal crafts at SMA Negeri 1 Panyabung Utara. The main source of problems in research is that students tend to be more passive and less creative, so that they are constrained in generating ideas for metal work. This study aims to increase students' creativity by utilizing aluminum waste and to find out the form of metal crafts produced by utilizing aluminum waste with press carving and filigree techniques. Data collection techniques in this study are active participation observation techniques, interviews and documentation. The data analysis technique uses descriptive qualitative analysis. The results of the study proved that there was an increase in the creativity of class XI students in making various metal craft products. To increase students' creativity in utilizing aluminum waste, several important stages are carried out, namely sorting materials, preparing equipment, making designs/sketches, the creative process of making decorative and functional metal craft products. In addition, to measure students' abilities can be seen based on creativity in designing works, perseverance in working on works and students' skills in making works. Efforts are made to increase student creativity, namely by providing motivation using varied learning media and displaying visual forms in the form of videos of metal craft work processes and photos of examples of metal craft products.
Assessment of the condition of balsamic poplar (Populus Balsamifera L.) in the green spaces of Bratsk
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Garus Ivan A. , Runova Elena M. , Orlova Yulia Yulia V.
Published: November 2023

The article is devoted to the study of the state of balsamic poplar (Populus balsamifera L.) in the conditions of industrial centers of Siberia on the example of the city of Bratsk. Bratsk is characterized by harsh natural and climatic conditions, high levels of pollution by gaseous and solid emissions, and is included in the Federal Clean Air Project. (Populus balsamifera L.) introduced poplar (native to North America) has adapted so well to the conditions of Eastern Siberia that it can be classified as an invasive species with a high probability, since vegetative reproduction has allowed it to become the dominant species of the city’s green spaces. Comprehensive studies of the condition of balsamic poplar in the urban environment have been carried out. A total of 2.586 trees were examined, of which 623 trees were modern, for which instrumental research methods were used. Based on the conducted studies, it was found that the life expectancy of poplars in a polluted urban environment, especially along highways, is no more than 20‑30 years. By the age of 30‑40, poplars are already in critical condition, shrink or even belong to the old deadwood (4‑5 points of vital condition). Poplar trees are vulnerable to sound rot and other diseases of wood and leaves. According to instrumental observation, more than 50% of all poplars in Bratsk are affected by various diseases and rot. Based on the studies
Improving the efficiency of extinguishing wildfires with forest fire extinguishers
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Zhuravleva Larisa A. , Apatenko Alexey S.
Published: November 2023

Patrolling recreation areas and extinguishing un-extinguished fires is one of the effective methods of preventing forest fires. Portable knapsack forest fire extinguishers are the most common due to their simplicity and ease of use by technical means of extinguishing forest fires. Their common disadvantages are low efficiency and high consumption of extinguishing agents. The purpose of the study is to increase the efficiency of extinguishing wildfires with the help of knapsack forest fire extinguishers based on the development of constructive and technical solutions and technological techniques that ensure economical use of fire extinguishing agents. The article presents studies of the characteristics of sprayed water and steam-water mixture affecting the extinguishing efficiency. The optimal ratio of the design parameters of the developed knapsack forest fire extinguishers is given. The concentration of water vapor in the air of more than 35% is sufficient to stop the process. Experimentalstudies confirm that sprayed water and steam-water mixtures are effective as independent extinguishing agents, and as a means of creating support strips. When creating support strips, the thickness of the condensate film should be at least 0.1 mm. The effective speed of a patroller with a steam generator should be 1.5‑2.5 km/h.