bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management
Authors: Abdul-Hammed Misbaudeen , Bello Isah Adewale , Olajide Monsurat , Adedotun Ibrahim Olaide , Afolabi Tolulope Irapada , Ibironke Ayobami Abimbola , Adebayo Barakat Dasola
Published: March 2023

This research is aimed at investigating the anti-colorectal cancer activities of phytochemicals from Mangifera indica (Mango) via the inhibition of thymidylate synthase (TS) and Nuclear Factor kappa B (NF–κB) using computational chemistry tools. Ligands (141 phytochemicals previously isolated from mangoes) and reference drugs (Raltitrexed and Emetine), the drug inhibitors of TS and NF–κB, respectively) were subjected to screening via ADMET profiling, drug-likeness analysis, oral bioavailability, PASS profile, and molecular interactions. Ligands that passed the previously mentioned screening were docked in duplicate against the target receptors (TS and NF–κB) using PyRx software. The mean values were calculated to obtain suitable docking scores. The analysis showed that TS was strongly inhibited by Friedelan-3beta-Ol with its lower binding energy of −9.0 kcal/mol more than Raltitrexed with a binding energy of −8.7 kcal/mol. NF–κB was also inhibited by Friedelan-3beta-Ol and Friedelin with binding energies of −8.0 and −8.1 kcal/mol, respectively, more than Emetine with a binding energy of −6.4 kcal/mol. These two phytochemicals performed much better than the standard drugs, thus selected as the best hits compounds because of their ADMET profile, drug-likeness properties, bioactivity, oral bioavailability, PASS prediction, binding affinities, and their interactions with the amino acids in the active sites of the receptors. Therefore, further studies are necessary for the validation of these claims toward the development of new effective and safer anti-colorectal cancer drugs.
Synthesis, structural and spectroscopic investigations of dolomite-type MSn(BO3)2 with M = Mn, Fe, Co and Ni
Authors: Wittmann Sarah , Murshed M. Mangir , Bilovol Vitaliy , Gesing Thorsten M.
Published: March 2023

Dolomite-type MSn(BO3)2 phases for M = Mn, Fe, Co and Ni have been synthesized using solid-state synthesis carried out in sealed quartz tubes. X-ray powder diffraction data Rietveld refinements confirm the rhombohedral space group

R

3
‾

$R\overline{3}$

for all compositions. The change in unit-cell parameters follows the increasing nature of the radius of the M-cations. Both the MO6 and SnO6 octahedra are found to be quite regular. 119Sn Mössbauer spectroscopy investigations complement the almost undistorted nature of the SnO6 octahedra and the tetra-valent charge of the tin-atoms. Detailed vibrational features are described from the Raman and the FTIR spectral data collected at ambient conditions. The frequency shifts of some selective Raman and IR bands are explained in terms of the change of cationic sizes and the respective M–O bond distances. The UV/Vis diffuse reflectance data are analyzed using the RATD method, leading to direct bandgaps for all the investigated samples. The wide bandgap semiconductors (3 – 4 eV) show increasing transition energies with increasing cation sizes of the high-spin M-cations in the dolomite types.
MIDDLE EAST ECHO OF THE EUROPEAN WAR. PART 2
Authors:   Institute of Europe, Russian Academy of Sciences, Shumilin Alexander
Published: March 2023

In the second part of the article, the author considers the attitudes of the leading countries of the Middle East region in relation to what is happening around Ukraine in general and Russia in particular. In his opinion, the previously described political models of Saudi Arabia, the United Arab Emirates and Turkey regarding the Ukrainian conflict remain the same even after a year of hostilityes. In fact, Iran and Israel also adhere to a similar approach to this problem. Its features in relation to each of these countries are highlighted in detail in this part of the article. At the same time, however, the author focuses on a more distinct manifestation of the basic attitudes that underlie the real policy of Tehran (pro-Russian) and Jerusalem (within the framework of the «collective West») in relation to what is happening around Ukraine. These differences have led to a spike in tensions between the two warring Middle Eastern states and even to what appears to be Israeli drone strikes on a military installation in Iranian Isfahan on January 29th. This attack, coupled with the supply of an impressive amount of Iranian weapons to Russia, weakens the military potential of the Islamic Republic, which is positively perceived by its rivals in the region – the Arab monarchies of the Persian Gulf. The author’s conclusion is as follows: hostilities on the territory of Ukraine are beginning to have a growing influence on the military-political situation in the Middle East and the Persian Gulf.
FUTURE OF EUROPEAN POLITICAL COMMUNITY: PRIORITY OF IDEOLOGY OR GEOPOLITICS?
Authors:   Institute of Europe, Russian Academy of Sciences, Guseletov Boris
Published: March 2023

The article presents the results of the analysis of the process of creating a new pan– European interstate entity – the European Political Community (EPC). This project was initiated by French President E. Macron in May 2022 and immediately received support from the leaders of leading European countries, as well as the leadership of the European Council and the European Commission. On October 6, 2022, the first summit of the European Political Community was held in Prague, which was attended by the heads of state and government of 44 countries, including the United Kingdom, as well as the heads of the European Council and the European Commission. The main topics on the agenda of this summit was the energy crisis, as well as the strategy for further development of this project. Particular attention within the framework of the EPC was aroused by the desire of the UK leadership to take part in it and thereby try to restore cooperation with the European Union. Given the role and influence of this country on the international agenda, its participation in this project will give it additional weight and influence. An analysis of the prospects for further development of the EPC shows that this project has serious potential, especially in the field of security, energy and infrastructure, which is confirmed by the participation of countries such as Azerbaijan and Turkey in it.
HUNGARIAN POLICY AGAINST THE BACKGROUND OF THE RUSSIAN SMO
Authors:   Institute of Europe, Russian Academy of Sciences, Shishelina Lyubov
Published: March 2023

The Author analyses position of Hungary at the background of an active phase of Russian special military operation in Ukraine. The research is being based on facts as well as on the analyses of public speeches of leading Hungarian politics and publications of known national experts. Like in other Central European countries, Hungary has been worried by Russian propositions to bring back the system of European security to the contours of 1997. Still Victor Orban did not refuse from the visit to Moscow traditionally scheduled to February. In general, position of Hungary ion 2022 can be estimated as neutral to both sides of the conflict. Both special geopolitical situation of the country as well as quite successful pragmatic relations with Moscow. In describing the conflict as well as reaction to it, the author sticks to terminology used in political space of Hungary and Visegrad region.
Tetrazolium Test for Evaluating Viability of Stored Rice (Oryza Sativa) Seeds
Authors: Sukkaew N. , Kaewnaborn J. , Soonsuwon W. , Wongvarodom V.
Published: March 2023

Germination testing of rice seeds takes 14 days, while the tetrazolium test can characterise seed viability in hours. The goal of this study was to evaluate the viability of stored rice seeds cv. Chiang Phatthalung by a practical and efficient tetrazolium method. Seeds were stored at
room temperature (28°C) and in cold storage (10°C) for 0, 3, 6, 9 and 12 months and then their viability and physiological quality was tested. Seeds of all treatments were soaked in water for 18 hours, cut longitudinally and immersed in 1% tetrazolium solution for two hours at 30°C
according to the ISTA method, or in tetrazolium solution at different concentrations (0.0625, 0.125, 0.25 and 0.5%) and staining temperatures (30, 35, 40 and 45°C). The modified tetrazolium test with 0.125% tetrazolium concentration and staining at 40°C of stored rice seeds correlated
positively with standard germination (r = 0.98, P < 0.01), soil seedling emergence (r = 0.98, P < 0.01), shoot length (r = 0.78, P < 0.01), root length (r = 0.81, P < 0.01) and seedling dry weight (r = 0.75,
P < 0.01). Thus, this staining condition can be used to efficiently estimate the viability of freshly harvested and stored rice seeds.
Lawatan Sejarah untuk Menanamkan Nilai Konservasi Cagar Budaya Pokok Bahasan Sejarah Hindu-Buddha di SMA Negeri 1 Talun Pekalongan
Authors: Yuliani Siska Ayu , Bain Bain
Published: March 2023

The objectives of this study were (1) to get an overview of the stages in carrying out enrichment learning to visit sites around the school in SMA Negeri 1 Talun Pekalongan; (2) find out whether the historical visiting model made student knowledge broader and deeper; (3) find out how teachers instilled values conservation using a historical tour learning model. This research uses qualitative methods with a case study strategy in SMA Negeri 1 Talun Pekalongan. The results in this study are (1) the learning tour at the Watu Sumur site, the teacher explains the material related to the heritage site, while the visiting learning at Jolotigo the teacher only accompanies students, does not explain the object. This is due to the access to relics in people's homes. (2) Cognitive knowledge and students' understanding of the sites at Watu Sumur and Jolotigo can be identified based on observations and questions and answers from researchers to students. (3) The teacher instills the value of cultural heritage conservation in students by publishing heritage sites on social media such as Faceook and WhatsApp.
Cultural Penetration: Post-Modern Threat to Historical Learning
Authors: Mareta Yoan , Rukmana Lisa , Yaldi Destri
Published: March 2023

According to the view of post-modernism in the world of education, humans are no longer subjects and actors to take advantage of science and technology but fall trapped into objects and targets controlled by science and technology as a product of modernism. In fact, technology and information are currently the solution to the development of creativity in the learning process which is also reflected in the implementation of the independent learning curriculum. This research uses a qualitative paradigm with a literature study method. In-depth analysis of the process of elaboration and subjective meaning are the thing that is most highlighted in qualitative research. The theory is then used as a guide to align the research focus with the facts of the field. The research results obtained are described as follows: Post-Modern Threats, Cultural penetration in the historical learning, and Digitalization and historical empathy. The conclusion is that digitization in historical learning is an important literacy process and really requires technological advances. But furthermore, the packaging must still include the essence of the nation's values and character.
Prospective History Teachers Worldviews on Sensitive and Controversial Issues in History Classes
Authors: Fitrianto Robby Fajar , Kurniawan Ganda Febri
Published: March 2023

This study aims to analyze the teacher's world view of sensitive and controversial issues in history learning. This research was carried out using qualitative methods with a descriptive approach. This study involved 90 participants. Data collection in this study used interview techniques relying on two techniques: first, one-on-one interviews with informants and second, group interviews or clustered discussions. Analysis of the research data using an interactive model. The results of this study indicate that the concept of sensitive and controversial issues in history learning has an important position for developing the thinking skills of prospective history teachers. To be able to manage sensitive and controversial issues requires an understanding of innovative learning strategies and evaluations. This study concludes that sensitive and controversial issues in history learning need to be mastered by history teacher candidates who are currently studying, so that this knowledge can have implications for history lessons that train critical thinking skills in schools.
The Role of the Millennial Generation in the Creativity of the Anti-Money Politics Movement
Authors: Huda Muhammad Wahyu Saiful , Raharjanti Pramestya , Pramesti Anggita Putri , Dewi Tanti Liana , Sharon Sam
Published: March 2023

Indonesia in its government system uses democracy, which means that it upholds human rights. Especially about the election of their representatives in government. In this election of representatives, the people are given the right to vote to elect their representatives in running the government of the State of Indonesia. However, in practice there are several obstacles and even violations, for example money politics. These violations have undermined the value of the general election. However, there is a group in the general election that has a big role, namely millennials. Because of this, it is necessary to examine the legal polemic regarding money politics and how millennials can come to take part. The method used is normative juridical. The result is that the law in Indonesia has included regulations regarding money politics. However, in terms of implementing sanctions, it is still less than law enforcers, therefore this position can be filled by millennials. And millennials can also carry out fair and honest elections.
Influence of temperature of thermal modification on the fire-technical characteristics of spruce wood
Authors: Luptáková Jana , Kačík František , Mitterová Iveta , Zachar Martin
Published: March 2023

Thermal modification is a widely used wood protection method. This method has attracted attention because there are no toxic chemicals used in the process. The influence of thermal modification was investigated relative to the ignitability and the mass burning rate of Norway spruce wood (Picea abies). The spruce wood samples were subjected to temperatures of 100 °C, 150 °C, 200 °C, 220 °C, 240 °C, and 260 °C for durations of 1 h, 3 h, and 5 h. The treatment at temperatures higher than 200 °C resulted in a lower mass loss at 600 s and a lower average relative burning rate, but it did not influence ignition time, the flame-died-out time, and maximum relative burning rate. The class of reaction to fire of the spruce wood samples was not changed due to the treatment. Therefore, it can be stated that the thermal treatment at temperatures below 200 °C does not influence the fire safety of an important class of wooden products.
Viscoelastic behaviors and microstructure of Sapindus mukorossi pericarp for different moisture contents
Authors: Xu Mengjiao , Tian Cheng , Xu Daochun
Published: March 2023

The viscoelastic behavior of Sapindus mukorossi pericarp (the covering of the Indian soapberry fruit) was investigated. Samples were subjected to creep-recovery and oscillatory shear tests. The moisture content had a strong effect on the dynamic moduli, whereas the temperature had little effect. Both the storage and loss moduli had a weak dependency on the frequency. In general, the storage and loss moduli decreased and slowly converged with an increase in the moisture content. The storage and loss moduli decreased with an increasing temperature. The creep-recovery experiment and dynamic shear tests indicated that the pericarps with high moisture contents were more prone to permanent deformation. The dynamic shear tests further demonstrated that a low moisture content, temperature, and frequency resulted in the pericarps having a more solid behavior and undergoing elastic deformation. Images of the microstructure showed that cells in the raw pericarps were round, of similar size, and neatly arranged. In the treated pericarps, the cells gradually became smaller and finally disappeared. It was inferred that drying with hot air caused the loss of intracellular substances, which in turn strengthened the dynamic characteristics of the pericarps. The completely dried pericarps thus behaved as strong viscoelastic solid in contrast to the raw pericarps.
Microwave and steam mediated alkaline pretreatments of sweet sorghum bagasse: Study of the energy efficiency
Authors: Vintila Teodor , Sumalan Radu , Popa Nicolae Florin , Dragomirescu Monica , Sala Florin
Published: March 2023

The effects of microwave and steam mediated pretreatments were evaluated and compared relative to the hydrolysis of sweet sorghum bagasse (SSB) in the presence of sodium hydroxide. The results established the optimum parameters for energy consumption and sugar production after hydrolysis of the pretreated SSB. The energy balance was better in microwave treatment compared with the steam treatment. The results recommended pretreatment at 300 watts power setting in the microwave oven up to 10 min. At higher wattage setting and longer exposure time, increased sugar yields were obtained, although the efficiency of the process decreased when the energy balance was calculated. The energy balance was calculated as the proportion of energy consumed during the pretreatments to the energy that can be produced by fermenting released glucose to ethanol. In this study, the energy consumed during the different pretreatments varied from 1/33 to 1/200 of the energy obtainable by fermenting released glucose to ethanol. Overall, the pretreatment of SSB to produce fermentable sugars was effective, and the energy balance was positive both in microwave and steam pretreatments of alkaline suspension of SSB. In microwave treatment the energy applied can be more accurately dosed, and consequently the energy balance was improved compared to steam treatment.
COMPREHENSIVE ASSESSMENT OF THE LABOR POTENTIAL OF THE REGIONS OF UKRAINE
Authors:   D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kyiv, Prokopenko N.A.
Published: March 2023

The article substantiates the main problems affecting the state and development of the labor potential of the regions of Ukraine and the state as a whole. Theoretical and methodological aspects and the evolution of approaches to the study of the essence and assessment of the labor potential of the region are highlighted. The author’s approach to the interpretation of the structure of the labor potential of the region with the justification of its quantitative and qualitative characteristics is proposed, methodological tools for assessing the state of the labor potential of the region are developed. The methodology was tested on official statistical data on the regions of Ukraine for 2020. Based on the analysis of the obtained integral characteristics, the regions of Ukraine were grouped, taking into account the qualitative and quantitative components of the labor potential. Spatial regularities in the placement of the labor potential of the territories of Ukraine are revealed. Most regions of the southwestern part of Ukraine are characterized by high levels of the qualitative component of the labor potential (mainly due to high health indicators) and high levels of the quantitative component of the labor potential, but it has been found that the existing labor potential in these regions is not used effectively. Large industrial regions in the east of Ukraine have a high level of the qualitative component, but an insufficient level of the quantitative component of the labor potential. The northern regions of the country are characterized by low indicators of both quantitative and qualitative components. Firstly, it concerns the Chernihiv and Sumy regions. Southern regions, such as Mykolaiv and Kherson regions, are characterized by high rates of the quantitative component of the labor potential against the background of a low level of the qualitative component. Kyiv is the only region with a high level of qualitative and quantitative component of labor potential. The results of the study can be used in the course of the implementation of the state regional policy, in the activities of municipal and regional governments when making strategic and operational decisions.
CONCEPTUAL MODELING FOR ECOTOURISM GEOINFORMATION SUPPORT
Authors:   Kyiv Taras Shevchenko National University, Liashenko D.O. , Koper N.Ye. ,   Hutsulshchina National Nature Park
Published: March 2023

The goal of the article is to define conceptual models in cartography. The conceptual model is a non-software description of a research field, describing its objectives, inputs, outputs, content, assumptions, and simplifications for the purposes of mapping or database creation. The article identifies the features of conceptual modeling in the process of creating and using maps for the organization of activities in the field of eco-tourism. It is emphasized that the creation of a conceptual model is associated with a set of ideas, beliefs, values, and worldviews (hidden picture of reality), formed by the researcher and the reader of the map. The article proposes a conceptual model of ecological tourism for geoinformation modeling tasks.
Data to Decisions: How to Make Science More Relevant for Management of the San Francisco Estuary
Authors:   Independent Consultant, Sommer Ted , Conrad J. Louise ,   California Department of Water Resources, Culberson Steven ,   Delta Stewardship Council
Published: March 2023

Science is the foundation for a wide range of activities, including evaluation, innovation, and technology, which in turn support management. Without good science, resource management in regions such as the estuary is handicapped, and must proceed with outdated conceptual models, operating strategies, and technologies. At the same time, we recognize that poor communication can interfere with conversations between scientists and managers, even when high-quality data and publications are available. In this essay, we have tried to address an important part of this issue: helping scientists to understand how to produce actionable science. Our hope is that these suggestions will, at the least, help improve dialog between scientists and the managers responsible for the estuary’s resources.
The Flood Risk and Water Supply Implications of Seasonal Precipitation Reconstructions in Northern California
Authors: Howard Ian , Stahle David , Torbenson Max , Granato–Souza Daniela , Poulsen Cody
Published: March 2023

Subsets of annual and sub-annual tree-ring chronologies are used to reconstruct seasonal precipitation totals in northern California. The specific seasons selected for reconstruction are based on the strongest monthly precipitation signals recorded in the tree-ring data. Earlywood width of gray pine is best correlated with Oct-Dec precipitation at the onset of the wet season. Latewood width of ponderosa pine is correlated with Mar–Apr totals at the end of the wet season. These earlywood and latewood width chronologies are used to develop separate reconstructions of precipitation for the “autumn” (Oct–Dec) and “spring” (Mar–Apr) seasons. Total ring-width chronologies of blue oak are highly correlated with October–April precipitation totals and are used to reconstruct precipitation for the “wet season.” We then computed one additional skillful reconstruction by subtracting the reconstructed spring totals from the wet season precipitation estimates (i.e., “winter” [Oct–Feb]). We compare the winter and spring reconstructions because they are well calibrated and provide an interesting long-term perspective on the interaction of winter–spring precipitation amounts near March 1, when important reservoir management decisions are often made. Consecutive wet winter and very wet spring precipitation anomalies increased after 1950 in the instrumental and reconstructed time-series, often coinciding with the largest spring streamflow and flood events recorded on the American River at Folsom. Once the sub-annual tree-ring data can be improved, it may be possible to develop discrete reconstructions of early-, middle-, and late-season precipitation for the past 250 to 500 years, to help define natural variability and anthropogenic forcing of seasonal precipitation totals in California.
Retracing labial-velar consonants in Mbum (Adamawa)
Authors: Beyer Klaus , Kunzmann Janika
Published: March 2023

Labial-velar consonants, which are typologically rather rare in the languages of the world, have been used for both genealogical and areal classification purposes. The claim that their occurrence mainly signals areal contact (e.g. Güldemann 2008), has been criticized by scholars (cf. Cahill 2017, Childs 2017) who point out a possible genealogical development in multiple language families of Africa. In this paper, we analyse contemporary and historical data on Mbum varieties from the Adamawa plateau in Cameroon and closely related languages of the Kebi-Benue family to approach the question whether labial-velars are transmitted merely through contact in these languages or warrant a genealogical explanation. The bottom-up approach leads to an interpretation of the current distribution of labial-velars that has both elements in it: There are arguments for reconstructing labial-velars for the Proto-Kebi-Benue level, but certain specifics of their geographical distribution also hint at a contact explanation.
The Republic of Korea and the Republic of Türkiye: A Comparative Analysis of the “Brotherhood in Spirit”
Authors: Avatkov Vladimir A. , Agafonova Yana V.
Published: March 2023

Introduction. The choice of Korea and Türkiye to analyze the behavior model within the framework of the changing international order is primarily due to such facts as maintaining close ties with Washington since their formation and their reference to each other as “brothers in blood”. Nevertheless, the historical paradigm of building the foreign policies has shown that there are some common directions that should be marked as “brotherhood in spirit”. The comparative analysis given in the article identifies the modern behavioral models of “the land of morning calm” and the Republic of Türkiye towards a changing geopolitical reality. The purpose of the study is to analyze the common points of intersection in the political processes of the two republics from the moment of their formation to the present days, also to identify the role of the “middle powers” during the Ukrainian crisis.

Materials and Methods. The methods of induction and deduction, the method of content analysis, the method of comparison and analysis, and the statistical method as well as the civilizational approach were used in the research process. Due to the methods used, the authors of the article have managed to conduct a comparative analysis in these planes. The information base was made up of materials presented in news sources, statistical materials of international organizations, publications of scientists and experts.

Results. A comprehensive country comparative analysis of states’ foreign policy trends in the XX and XXI centuries has been carried out, as well as their interaction with the “West” and the “westernization” of their course at the present stage – “brotherhood in spirit”. Also, the researchers have carried out main conclusions on their role of middle powers and regional actors due to the ongoing tectonic shifts in the international paradigm.

Discussion and Сonclusion. Analyzing their “brotherhood in spirit” during the Ukrainian events, it is noted that Türkiye, in comparison with Korea, pursues a more independent course from the West, taking into account its own interests, while both are characterized by a “two-track” policy. Both states are taking a wait-and-see position in the conditions of the emerging political conjuncture of global interaction. The practical significance of the work is the analysis of the behavior of two countries – Korea and Türkiye – as “middle powers” in a changing world order. The obtained results can contribute to further study the role of this type of state in the “West–non-West” relationship.
Assessment of the Climate Impact on the Economic Variables of Monetary Policy: Regional Approach
Authors: Arzhenovskiy Sergey V. , Sinyavskaya Tatiana G. , Nikogosyan Vardan M.
Published: March 2023

Introduction. The relevance of quantitative analysis of the impact of climate variables on macroeconomic indicators of monetary policy according to Russian data in the regional aspect is due to the absence of such research. The purpose of the article is to perform a quantitative assessment of the climate change impact on key macroeconomic variables of monetary policy on panel data by Russian regions.

Materials and Methods. Russian regions were the subject of the study. For calculations, the authors have formed the information base for 79 regions of the Russian Federation from 2000 to 2020 according to Rosstat. The applied methodology is based on the author’s approach, combining the use of factor analysis by region at fixed year and econometric modeling using integral factors obtained at the previous stage on the panel data by region. Econometric analysis was performed using a generalized method of moments and a two-stage systematic generalized method of moments.

Results. The significant impact of climate change on key macroeconomic variables controlled in the development and implementation of monetary policy measures – gross regional product and consumer price index – has been identified empirically. The research was based on econometric modeling.

Discussion and Conclusion. Objective climate change taking place in the Russian regions may adversely affect the economic situation, which requires intensification of implementation and development of measures aimed at improving the environmental situation: reduction of CO2 emissions, development and use of forest-saving technologies, etc. It is proposed to consider the climate situation in the implementation of monetary policy. The results of the research will be useful both in the development and implementation of regional policy, and for specialists, civil servants who plan to improve the territorial structure of the economic space of Russia in the long term.
“Soft” Factors for Ensuring Spatial Integration of Russia’s Northern Regions
Authors: Kozhevnikov Sergey A.
Published: March 2023

Introduction. Despite the fact that the problem of spatial integration is widely studied by scientists, science has not developed an unambiguous understanding of the factors that ensure it in practice. At the same time, the experience of developed countries indicates an increase in the role of non-economic (“soft”) factors, which include close social ties between territories. The purpose of the article is to study the social ties of the population of the northern regions of Russia from the standpoint of considering them as a “soft” factor in the integration of the socio-economic space.

Materials and Methods. The object of research is the European North of Russia as an open regional socio-economic system. The theoretical part of the study is based on a critical analysis of the scientific literature on the issues of spatial integration and the study of social ties as a factor that ensures it. The analytical part is based on the use of a sound methodological approach to the study of social ties of territories, based on the results of a comprehensive analysis of the Big Data of the social network “VKontakteˮ, as well as sociological surveys of residents.

Results. The role of social ties as a “soft” factor of spatial integration is substantiated. Using the developed methodological approach, the internal social ties of the northern territories, the trends towards their spatial transformation associated with the active centripetal vector of population migration to the large cities of the region, as well as St. Petersburg and Moscow, have been revealed. This leads both to the activation of agglomeration processes and to the rupture of ties with remote territories.

Discussion and Conclusion. The hypothesis about the presence of closer ties between neighboring territories is confirmed, which is especially evident for the Arkhangelsk and Vologda regions. However, in order to deepen integration processes, it is also important to support their production, economic, cultural, educational and other ties. The scientific significance of the work lies in the expansion of approaches to the study of spatial integration factors; substantiation of tools for a comprehensive assessment of the social ties of territories. The practical significance lies in identifying trends and directions for the spatial transformation of the social ties of the European North of Russia, which will serve as the basis for the development of effective management decisions in the field of coordinating the socio-economic development of the northern territories of Russia.
Метафоризация и безумство: «Красный цветок» Вс. М. Гаршина
Authors: Молнар Ангелика
Published: March 2023

В статье рассматривается тема безумства в рассказе Вс. М. Гаршина «Красный цветок» с несколько иного, чем в критической литературе, ракурса, так как в центре внимания стоит не психиатрическая проблематика, а процесс конструирования дискурса болезни. В ходе разбора текста рассказа приво-дятся также некоторые переклички, например, со «Сном смешного человека» Ф. М. Достоевского и «Палатой № 6» А. П. Чехова. Межтекстуальная связь с этими повестями основывается на идее усо-вершенствования мира и на акте его метафорического переименования. Однако в рассказе Гаршина не наблюдается ни переосмысление героем своей «великой мысли», которая преследует цель спасе-ния, но результатируется в уничтожении красоты и делает героя похожим на монстра, ни создание об этом персонального повествования, в котором он критически относился бы к своему слову.

Автор статьи рассматривает, как слово героя конфликтует с «языком медицины»: герой обозна-чает мир больницы по-своему, в отличие от рационального рассказчика (врача?) «Красного цвет-ка». Двойственность структуры (реалистически объясняющий речь и мысли героя рассказ) может получить свое разрешение на уровне дискурса. В статье исследуются мотивный и метафорический планы текста рассказа именно с такой точки зрения. Это приводит к выводам, отличающимся от аллегорического или символического анализа, в частности, и в связи с красным цветком, огнем, сном, луной.

При этом автор статьи обращает внимание и на фонограмматические инновации, как квази- этимоны, омонимы и созвучия, которые порождают новый смысл: см. например, глаголы «сажать» и «рвать», а также слова-имена, обозначающие части растений или связанные с ними: «лепестки», «теплица» и т. п. Под таким, особым углом зрения раскрывается возможность сопоставления образа и идеи героя с красным цветком, и, следовательно, интерпретации его истории как саморазрушения для нового рождения. Сюжет рассказа можно толковать и как литературное переложение компози-ции волшебных сказок, между тем автор статьи фокусируется на раскрытии особого языка больно-го, метафоризируемого как распускание бутона.

В этой связи изучается и означивание вещей, которое играет важную роль в выстраивании дис-курсивного плана, направленного на развязку: освобождение из смирительной, «сумасшедшей» рубахи в сюжетосложении параллельно отталкиванию от традиционных форм, связывающих речь, на уровне поэтического слова. Метафорический язык начинает постепенно доминировать в тексте и становится развязкой «сумасшедшего» нарратива в дискурсивной презентации истории.
Symbolika farieb a kvetov v zbierke Rudolfa Dilonga Helena nosí ľaliu (1935) ako súčasť realizácie motívu života a smrti
Authors: Norba Olha
Published: March 2023

Štúdia sa zameriava na analýzu zbierky Helena nosí ľaliu (1935), ktorú treba chápať ako dôležitý medzník v poetike básnika Rudolfa Dilonga – dochádza v nej k poeticko-metodickému obratu smerom ku modernejším umeleckým snahám. Zároveň sa hĺbkovo-motivický základ jeho tvorby nemodernizoval, ale paradoxne práve náboženstvo slúžilo ako energetický zdroj poetickej modernizácie. Hlbšie vniknutie do nej môže poslúžiť ako prínosný základ pre pochopenie celej zbierky, pretože náboženské motívy sú ukotvené v použitých symboloch a zaručujú ich platnosť. Vysoká úroveň symbolizácie je takisto organickou súčasťou avantgardnej poetiky, ktorej cieľom je prerušiť kauzalitu empirickej skutočnosti – odmietajúc dominanciu racionality a vyzdvihujúc rolu práve zmyslového vnímania sa otvoril priestor pre realizáciu Dilongovej túžby po úniku, vytvorením si „šťastnejšej“ alternatívnej reality.

V zbierke Helena nosí ľaliu Rudolf Dilong zrealizoval 8 kvetinových (fialka, ľalia, konvalinka, kvet maku, narcis, ďatelina, astra a ruža) a 8 farebných symbolov (biela, zelená, červená príp. ružová, zlatá, strieborná, modrá, fialová, čierna), ktoré spolu fungujú ako funkčné ideové nositele a ponúkajú bohatú paletu interpretačných možností. Základom pre ich analýzu slúžia všeobecné znalosti o symbolike farieb a kvetov spolu s analýzou nielen explicitnej, ale aj implicitnej symboliky. Integrovaním do textu interpretácií vybraných básni sa jednak dosahuje porovnávanie tradičného chápania jednotlivých symbolov a hlbšie vniknutie do motivickej roviny autora, a jednak sa čiastkové poznatky na konkrétnych príkladoch syntetizujú.

Farebné a kvetinové symboly prispeli k realizácii hlavných motívov básnickej zbierky, akými sú smrť a život. Ideové kolísanie medzi týmito protikladnými pólmi zároveň koreluje s motivickým základom básní, tkvejúcim v kresťanských postulátoch, veď život v ľudskom ponímaní sa vidí ako príprava pre život „skutočný“, ktorý prichádza po smrti. Nadväzujú na to aj paradoxy, sprevádzajúce život františkánskeho básnika – inšpiračné zdroje v podobe žien, viery, detstva a stratenej vlasti alebo cudziny, ktoré odhaľujú deficity „dočasného života“. Dichotomická podoba symbolickej roviny zbierky sa manifestuje v rozdelení farieb na farby, ktoré preukazujú skôr pozitívnu konotáciu a zodpovedajú pólu života a farby, ktoré evokujú skôr negatívne asociácie a korelujú s pólom smrti, neutralizačným a harmonizujúcim prostriedkom dvoch kontroverzných pól vystupuje biela farba. Podobný vzorec môžeme aplikovať aj na symboly kvetov. Ústredným symbolom sa stáva kvietok ľalie, ktorý sa podobne ako biela farba prejavuje ako dichotomický prvok a stelesňuje kvintesenciu autorových snáh ideovej realizácie ústredných motívov zbierky.
Prognosis of abnormal uterine bleeding in women of reproductive age with extragenital disorders
Authors: Blagoveshchensky Roman , Tuchkina Iryna
Published: March 2023

The purpose of the study was to elaborate on a prognostic model for predicting the development of abnormal uterine bleeding in women of reproductive age with accompanying extragenital disorders based on mathematical methods.

Materials and methods. The study, which was in 2019-2022, involved 100 women of reproductive age with AUB and accompanying extragenital disorders under observation, who made up the main group. The control group comprised 50 women of reproductive age undergoing medical checkups. On the basis of 23 diagnostic indicators, the most informative ones were mathematically selected for the prognosis of AUB in women with extragenital abnormalities.

Results and their discussion. The prognosis of the risk of developing AUB in women of reproductive age with extragenital disorders was carried out on a double scale (0 – low probability, 1 – high probability). The search for diagnostically informative factors involved a set of 23 working indicators that were investigated in the examined patients using four levels of the risk scale. In order to solve this issue, the factors that have the greatest importance in the formation of the prognosis were selected using discriminant analysis methods, and a corresponding mathematical model was created. The classification functions made it possible to enter the practical plane and form rules for assessing the presence/absence of the risk of developing AUB in patients of reproductive age with extragenital disorders. The corresponding expressions are the following equations:

NP = BAS ART*75.57+FSH*2.96+prolac*0.02+estrad*0.02-40.78

PP = BAS ART*105.35+FSH*0.79+prolac*0.1+estrad*0.08-114.49,

where NP is a negative prognosis, PP is a positive prognosis.

If NP > PP, then the most likely prognosis is the absence of AUB in the patient; otherwise, if PP > NP – there is an increased risk of AUB.

Conclusion. Pulsation index in the basal arteries of the uterus, FSH, prolactin and estrogens are prognostically significant indicators for predicting the risk of abnormal uterine bleeding in patients of reproductive age with extragenital disorders. The above formula, obtained from the conducted discriminant analysis, makes it possible to predict bleeding in a specific patient
Visualization of distance learning
Authors: Kondratova Lyudmila
Published: March 2023

The article is devoted to highlighting the current problems of creating visual support for distance learning of pedagogical workers in the conditions of postgraduate education. The current experience in training teachers to create a visualization of distance learning of teachers in postgraduate education is considered. Attention is paid to the modern problems of distance learning, the experience of organizing advanced training courses, implementation of thematic, author's courses for teachers of general secondary education institutions and vocational pre-higher education institutions is described. A description of the content of the training of teachers on the author's remote professional development courses is provided. A description of the preparation of a visual series for remote training of teachers in the postgraduate education system is given. Features of the use of modern digital tools and technology for creating electronic materials for the organization of distance learning are considered. A description of the use of video conferencing systems in distance learning is provided, examples of creating video materials for conducting distance classes are described. The experience of organizing distance classes is described and a description of the types of classes in distance learning is provided.
The list of problems of the pedagogical community in the process of organizing distance learning in crisis conditions is presented. The problems and needs of professional improvement of teachers, which can be solved during the period of professional development in the system of postgraduate education, are singled out.
The results of research in the post-graduate education system are described, which demonstrate the solution to the problems of distance learning visualization based on the author's professional development courses. The meaningful content of distance, network, electronic training of teachers, the selection of effective technologies for the preparation of visual support for conducting classes in a distance format are recognized
Search procedure for optimal design and technological solutions to ensure dimensional and geometric accuracy of castings
Authors: Frolova Liliia
Published: March 2023

The object of research in the work is the technology of manufacturing shaped castings in disposable sand molds.
The existing problem is that the imperfection of design and technological solutions at the stage of developing the technology of a single sand mold casting leads to deviations in the dimensions and geometry of the castings after their manufacture from the requirements of technological documentation. This can lead to an irreparable shortage of casting.
To develop measures to eliminate or minimize the event, which consists in the formation of a shortage of castings in terms of dimensional and geometric accuracy, a procedure for searching for optimal design and technological solutions is proposed.
A hypothesis has been put forward that a significant factor that leads to deviations in the dimensional and geometric accuracy of castings from the requirements of technological documentation is the imperfection of the gating system design. It is demonstrated on specific castings how this factor can influence the formation of uneven wall thickness.
The proposed procedure, which includes 10 consecutive steps, allows to build a plan for a complete factorial experiment and obtain a regression equation for it, linking the parameters of the gating system with indicators of dimensional and geometric accuracy. The presence of such equations provides the possibility of further experimental optimization and determination of design and technological solutions for the development or improvement of casting systems that minimize the deviations of the dimensional and geometric accuracy of castings from the requirements of technological documentation. This also minimizes the likelihood of an event consisting in the formation of an irreparable shortage of castings.
The presented study will be useful for machine-building enterprises that have foundries in their structure, where shaped castings are made in disposable sand molds.
The effect of audit committee characteristics on earnings management in Nigerian listed firms
Authors: Kaoje Abdulsalam Nasiru , Alkali Mohammed Yusuf , Modibbo Abubakar
Published: March 2023

This study focuses on the effect of audit committee characteristics on earnings management among Listed Firms in Nigeria with aim to ascertain whether audit committee characteristics has effect on earnings management. Audit committee in an organization is to support firm’s governance and oversight functions with the regard to financial reporting, risk management system internal control structure, ethical accountability and internal and external audit functions. Earnings management is an attempt by managers to alter financial information either for their private gain or for the gain of stockholders. The study population was 190 firms listed in the Nigerian Stock Market. The study sample was 150 firms because 40 firms could not provide the needed data for the study as at 2014 to 2019. The study data was generated from the Thomson Reuters Data stream and other variables were handpicked from the firm’s annual reports covering the period of 2014–2019. A Generalized Least Square (GLS) estimator was used in estimating the parameters. The study provides positive and significant relationship between Audit Committee Independence (ACIND), Audit Committee Meetings (ACMT) and Earnings Management of listed Nigerian Firms in Nigeria. However, negative relationship between Audit Committee Size, Audit Committee Financial Expertise, Firm Size and Earnings Management was reported among the Listed Firms in Nigeria. Policy maker should provide policy on the composition of Audit for the committee members to clearly spelt out to enable members perform their functions effectively. Further study should look at diversity of audit committee, ethnicity, and religious influence because of the Nigerian diversity on ethnicity and religion.