bluuebunny/crossref_metadata_2025 huggingface dataset:
PERSEPSI MASYARAKAT TERHADAP OBJEK DAN DAYA TARIK WISATA DI NEGERI ABUBU PULAU NUSALAUT KABUPATEN MALUKU TENGAH
Authors: Nasir Daniel Agung , Lelloltery Henderina , Sitanala Merlin Renny
Published: May 2023

natural resources and becomes an object and attraction for ecotourism. One of the areas that has become a tourist destination in Central Maluku Regency is the island of Nusalaut. However, tourist destinations in the archipelago have not been fully developed and known by tourists and widely promoted in various media. The objectives of this study were: to determine the public’s perception of tourism objects in the Abubu country, Central Maluku district and to identify the factors that influence public perception, in the Abubu country, the island of nusalaut. The method used in this research is purposive sampling, which is a method of collecting data by selecting respondents who are involved in tourism activities. To analyze the data using descriptive analysis based on the data obtained well through the results of questionnaires and interviews and then described by using percentage analysis.  The results of this study indicate that the people of Abubu Regency, Central Maluku   Regency are very supportive if there are tourism object development activities in Abubu Country.Maluku merupakan wilayah yang disebut daerah seribu pulau, memiliki potensi sumber daya    alam yang melimpah dan menjadi objek dan daya tarik ekowisata. Salah satu kawasan yang menjadi destinasi wisata di Kabupaten Maluku Tengah adalah pulau Nusalaut. Namun destinasi wisata objek wisata di negeri abubu pulau nusalaut belum sepenuhnya dikembangkan dan di ketahui oleh para wisatawan dan di promosikan secara luas, di berbagai media. Tujuan penelitian ini adalah: mengetahui persepsi masyarakat terhadap objek wisata di negeri abubu kabupaten Maluku tengah dan mengidentifikasi faktor faktor yang mempengaruhi persepsi masyarakat, di negeri abubu pulau nusalaut. Metode yang digunakan dalam penelitian ini adalah purpovise sempling yaitu suatu metode pengumpulan data dengan memilih responden yang terlibat dalam kegiatan wisata. Untuk menganalisis data yaitu menggunakan analisis deskriptif berdasarkan data yang di peroleh baik melalui hasil koisoner dan wawancara kemudian di deskripsikan dengan cara menggunakan analisis persetase. Hasil penelitian ini menunjukkan bahwa masyarakat negeri abubu kabupaten Maluku tengah sangat mendukung bila ada kegiatan pengembangan objek wisata di negeri abubu
PENGEMBANGAN INSTRUMEN PENILAIAN E-BOOK BERBASIS INQUIRY LEARNING
Authors: Wandri Rades , Vebrianto Rian , Zulfianti Gitania
Published: May 2023

Pengembangan instrumen ini dilakukan untuk melakukan evaluasi pada produk yang telah dikembangkan untuk mengetahui keefektifan penggunaan instrumen serta untuk menentukan validitas dan reliabilitas. Metodologi dalam penelitian menggunakan pengembangan Research and Development (R&D) pada model pengembangan 4D dengan menggunakan instrumen berupa angket yang terdiri dari 3 konstruk yaitu design produk, informasi yang dimuat, dan keefektifan produk. Studi survey ini melibatkan 7 orang guru dengan guru laki-laki 3 dan guru perempuan 4. Teknik pengumpulan data dilakukan dengan mengisi kuesioner secara online dengan berbantuan analisis program SPSS. Hasil dari pengujian validitas dan reliabilitas dapat menunjukkan bahwa data validitas memenuhi kriteria yang valid dan reliabel. Penelitian ini juga menunjukkan bahwa instrumen yang telah dikembangkan memenuhi syarat untuk digunakan dalam pengembangan media E-Book bagi peserta didik. Diharapkan para stakeholder dan pendidik dapat menggunakan instrumen ini dalam pengembangan media yang terkhususnya e-Book.
The Principle "Like Begets Like" in Molecular and Algebraic-Matrix Genetics
Authors: Petoukhov Sergey
Published: May 2023

This article is devoted to the results of in-depth analysis of the system of binary-oppositional structures in DNA n-plet alphabets and their algebraic-matrix representations. These results show that the molecular complementary replication of DNA strands is accompanied by the presence of an algebraic version of the principle "like begets like" in matrix representations of DNA alphabets having internal structures. This algebraic version is based on binary-oppositional structures in the genetic molecular system, which can be represented by binary numbers and corresponding matrices of DNA alphabets. The received results allow thinking that the phenomenon "like begets like" (or a complementary replication in a wide sense) is systemic in the genetic organization and is connected with algebraic features of biological organization. Correspondingly, the biological principle "like begets like" can be additionally modeled by algebraic-matrix methods and approaches. Such algebra-matrix modeling of the genetic coding system gives new ways for studying and understanding the key role of the named principle in genetic and other inherited physiological complexes. On this way, the author discovered general rules of stochastic organization of information binary sequences of genomic DNAs of eukaryotes and prokaryotes. The presented rules are connected with information dichotomies of probabilities and corresponding fractal-like trees of probabilities, which fundamentally differ from constructional dichotomies in biological bodies. The received phenomenological data and rules lead to new biological ideas.
Particulate Matter as One of Air Pollutants Impacts Asthma via the Tricellular Tight Junction Protein, LSR
Authors: Hwang Da Yeon , An Min-Hyeok , Lee Pureun-Haneul , Kim Jung-Hyun , Nam Yunha , Park Shinhee , Baek Ae-Rin , Jang An-Soo
Published: May 2023

The tricellular tight junction protein angulin-1/lipolysis-stimulated lipoprotein receptor (LSR) is associated with numerous signal transduction pathways that regulate gene expression, epithelial cell function, and morphogenesis. The impacts of particulate matter on LSR and asthma are not known. Therefore, the aim of the present study was to assess the impacts of particulate matter as one of air pollution on LSR expression in asthma. To this end, we investigated the involvement of LSR in the pathogenesis of bronchial asthma in an ovalbumin (OVA) mouse model of asthma exposed to titanium dioxide (TiO2), and examined plasma LSR levels and their relationship with clinical variables in asthma patients and healthy controls. Plasma LSR levels were lower in asthma patients than in healthy controls. Although plasma levels of receptor for advanced glycation end-products (RAGE) were lower in asthma patients than in healthy controls, high mobility group box protein 1 (HMGB1) levels did not differ between these groups. In asthma patients, LSR levels were correlated with the forced vital capacity percentage, ratio of forced expiration (first second)-to-forced vital capacity, white blood cell count, and blood lymphocyte proportion. In mice, LSR expression was significantly decreased in OVA mice compared with control mice, and changed in OVA mice exposed to TiO2. Transforming growth factor beta levels were increased in OVA mice compared with control mice, and changed in OVA mice exposed to TiO2. Overall, plasma LSR levels were decreased in asthma patients, and were influenced by exposure to air pollution. These findings suggest the involvement of LSR in the pathogenesis of asthma.
Signal Design, Detection, and Identification Technology for Ground-Penetrating Communication Based on Ground Electrode Current Field
Authors: He Jingang , Su Zhong , Xu Zhan , Zha Yaxing , Wen Xiaowen , Zhou Xin
Published: May 2023

In this work, we studies the principle of ground electrode current field through ground communication technology, signal design, and optimal working mode of excitation source, so as to adapt the working mode, working frequency, and transmission medium condition of signal transmission. Through waveform design, energy is concentrated in the main conduction direction, which is beneficial for signal filtering at the receiving end and achieving high reliability data transmission; On this basis, on-site environmental testing was conducted to verify the detection and recognition technology of weak signals. Signal design and detection recognition are a very important part of the grounding electrode current field through ground communication technology. The grounding electrode current field through ground communication technology is mainly applied to solve the problem of communication between rescue personnel and trapped personnel before and during tunnel engineering collapse and rescue.
The Study of an Energy Management Strategy Within a Mi-Crogrid With Photovoltaic Production of the <> Project in the City of Tangier and Integrating V2G Technology
Authors: Doudou Youssra , Cherkaoui Abdeljabbar , Ezziyyani Mostafa
Published: May 2023

The energy stored in an electric vehicle's battery would be drawn and distributed to the electrical grid to better drive energy consumption within a microgrid that includes a renewable generator(s) managed by a specific energy management strategy. This concept, known as vehicle-to-grid technology: V2G, makes the energy stored in the electric vehicle's battery more beneficial by discharging it to the public grid during periods of high demand. In this study, we will consider a vehicle system connected to a microgrid, which includes a photovoltaic generator reported from the <> project in the city of Tangier. We will elaborate the study of a strategy of the car connected to this V2G network. This allows electricity to be stored when rates are low (off-peak hours) and then used when prices rise (peak hours). Otherwise, the solar energy will cover the owner's needs, and the surplus will be injected into the distribution network. This strategy will manage the solar power, the load power, the state of charge of the EV battery, the time of day and the driving scenario. Using two driving profiles, we will show the performance of the proposed energy management strategy and the percentage contribution of the photovoltaic array of the <> project in the city of Tangier.
Leishmania Seroprevalence in Dogs: Comparing Shelter and Domestic Communities
Authors: Afonso Paulo , Coelho Ana Cláudia , Quintas Hélder , Cardoso Luís
Published: May 2023

Canine leishmaniosis (CanL) is a chronic, systemic and often severe disease. The main causative agent of CanL is a protozoan parasite, Leishmania infantum, with phlebotomine sand flies acting as vectors. In Europe and other continents, L. infantum is also responsible for leishmaniosis in other animals, such as cats, horses and humans. In Portugal, animal and human leishmanioses are endemic, and high prevalence levels of infection and disease have been reported in dogs. There is a prejudice against stray animals and also those housed in shelters, assuming they have higher levels of infection with vector-borne pathogens, including L. infantum, when compared to domestic animals. In north-eastern Portugal, serum samples were obtained from March to May 2022 in three shelters (n = 179) and 13 veterinary clinics (n = 164), resulting in 343 dogs being analysed for antibodies to Leishmania spp. by the direct agglutination test (DAT). The overall seroprevalence was 9.9%, with 15.2% seroprevalence in domestic dogs and 5.0% in the shelter ones (p = 0.003). The fact that shelter dogs had a lower seroprevalence could be explained by more regular veterinary care provided in shelters regarding preventive measures, including insecticides with an antifeeding effect, in comparison with domestic dogs.
A Japanese Prospective, Multicenter Study of Colonic Stenting for Palliation Using a High Axial Force Self-Expandable Metal Stent for Malignant Large Bowel Obstruction in 200 Patients
Authors: Ishibashi Rei , Sasaki Takashi , Isayama Hiroyuki , Matsuzawa Takeaki , Kuwai Toshio , Yamada Tomonori , Saito Shuji , Tomita Masafumi , Shiratori Toshiyasu , Ikeda Satoshi , Kanazawa Hideki , Fujishiro Mitsuhiro , Maetani Iruru , Saida Yoshihisa
Published: May 2023

Evidence of the efficacy and safety of colorectal stent placement for palliation remains insufficient. This single-arm, prospective, multicenter study with WallFlex enteral colonic stent included 200 consecutive patients with malignant large bowl obstruction in the palliation cohort. The technical and clinical success, as well as stent patency and complications as short-term (≤ 7 days) and long-term (> 7days) outcomes, of high axial force self-expandable metal stent (SEMS) placement was evaluated. The technical and clinical success rates were 98.5% and 94.5%, respectively. Non recurrent colorectal obstruction at 1 year was 63.9%, and 71.2% of the patients remained free of recurrent colorectal obstruction until death or the last follow-up. Fifty-six patients (28.0 %) received chemotherapy and five patients were administered bevacizumab after stent placement. The overall complication rate was 47%, including four (2.0%) early-onset and ten (5.0%) late-onset perforations, mostly due to stent-edge injury. Only the use of a long SEMS was a risk factor for perforation. In conclusion, endoscopic colorectal stenting using high axial force SEMS is an effective and safe procedure for palliation in patients with malignant colorectal obstruction. However, care should be taken to avoid perforation at the stent edge when using a long SEMS.
The Impact of Knowledge Creation of Mexican Engineering
Authors: Gonzalez Brambila Claudia N , Ponce José I. , Gonzalez Brambila Silvia B , Milia Matias F
Published: May 2023

Engineers make things, make things work, and make things work better and easier. This kind of knowledge is crucial for innovation, and much of the explicit knowledge developed by engineers is embodied in scientific publications. In this paper, we analyze the evolution of publications and citations in Engineering in a middle-income country such as Mexico. Using a database of all Mexican publications in Web of Science from 2004 to 2017, we explore the characteristics of publications that tend to have the greatest impact; this is the highest number of citations. Among the variables studied are the type of collaboration (no collaboration, domestic, bilateral, or multilateral), the number of coauthors and countries, the language of the article, controlling for a coauthor from the USA and the affiliation institution of the Mexican author(s). Our results emphasize the overall importance of joint international efforts and suggest that publications with the highest number of citations are those with multinational collaboration (coauthors from three or more countries), written in English, and when one of the coauthors is from the USA.
A Compact Planar Wi-Fi Antenna with Optimized Radiation Patterns for Small UAV Applications
Authors: Yang Ya-Lung , Lin Ding-Bing
Published: May 2023

This paper proposes a compact planar Wi-Fi antenna with optimized radiation patterns for small unmanned aerial vehicle (UAV) applications in both urban and open areas. It is suitable for being mounted on the outermost side of the non-metallic wing of the small UAV. It has small dimensions of 16.5 mm (L) by 30.3 mm (W) by 1.6 mm (h), and the measured results of its prototype are in agreement with simulated data. Its impedance bandwidths over the two frequency ranges are 2.11 to 2.58 GHz and 5.06 to 7.5 GHz (S11≤-10 dB). At 5.8 GHz, it has stronger radiation below the small UAV to reduce interference from rare-use directions. Its maximum radiations, the directions of the maximum radiation in each elevation plane, are below the UAV and between 14 and 29 degrees from the horizontal plane. At 2.4 GHz, it has quasi-omnidirectional radiation to ensure a stable link in all directions, and its maximum radiations are near the horizontal plane. The optimized radiation patterns at 5.8 and 2.4 GHz can provide more antenna gain when the small UAV flies farther in urban and open areas, respectively. In addition, it has good vertically polarized radiation for long-distance applications.
Molecular Insights into the Role of Gut Microbiota in Antibiotic Therapy Selection and Resistance Mitigation
Authors: Andreescu Mihaela
Published: May 2023

Antibiotic therapy is a cornerstone of modern medicine, yet the development of antibiotic re-sistance threatens to render these therapies ineffective. The gut microbiota, a complex ecosystem of microorganisms residing in the gastrointestinal tract, plays a critical role in modulating anti-biotic efficacy and resistance. This review delves into the intricate relationship between gut mi-crobiota, antibiotic therapy, and resistance, and discusses the potential applications of gut mi-crobiota research in guiding personalized antibiotic therapy and resistance mitigation strategies. Recent advancements in metagenomics, metatranscriptomics, and metabolomics have demon-strated the potential for tailored antibiotic regimens that minimize collateral damage to com-mensal bacteria and reduce the risk of resistance. Adjuvant therapies such as probiotics, prebi-otics, and synbiotics have shown promise in restoring gut microbial balance and mitigating the adverse effects of antibiotic therapy. We address the challenges associated with this emerging field including the need for standardized methodologies, ethical considerations, and interdisci-plinary collaboration. With continued interdisciplinary collaboration and the implementation of standardized methodologies, gut microbiota research can contribute to the global fight against antibiotic resistance and improve patient outcomes.
Spatiotemporal Variability in Soil Properties and Composition in Mangrove Forests in Baía de Todos os Santos (NE Brazil)
Authors: Ramos Mônica Arlinda Vasconcelos , Pérez-Alberti Augusto , Nóbrega Gabriel Nuto , Otero Xosé Luis
Published: May 2023

Baía de Todos os Santos is the second largest bay in Brazil and is home to important ecosystems, including estuarine systems and mangroves. However, studies on the seasonal variability of its soil properties and composition are still scarce. For this study, soil and leaf samples were seasonally collected from mangrove forests at four sites (Cacha Prego, Ponta Grossa, Ilha de Maré, and Pitinga), which are representative of different environmental conditions within the BTS. Soil physicochemical properties, soil composition and partition of Fe forms were determined, and analysis of minerals by Scanning Electron Microscope, was performed on soil samples. Isotopic ratios (δ13C, δ15N) were also determined on soil and leaf samples. Soils showed significant spatial and temporal changes affecting both their properties (pH, Eh) and their composition (TOC, pyrite and Fe oxyhydroxide contents). Clear spatial changes were observed in redox potential, significantly affecting the concentrations of the different geochemical forms of Fe, particularly the concentrations of crystalline oxyhydroxydes and pyrite in one of the studied sites. In three of the study sites, pyrite crystals showed clear evidence of degradation associated with sandy soils. Finally, δ13C and N/C ratios in soils seem to suggest a mixed origin of organic matter.
Physicochemical Properties of Three Types of Rice Bran Meal Dietary Fiber and Their Hypolipidemic Effects on Rats
Authors: Zhu Renwei , Wang Yayi , Zhang Linwei , Huang Liang
Published: May 2023

This study investigated the effects of three oil production methods on the physicochemical properties of dietary fiber from rice bran flour, and the hypolipidemic effects of the dietary fibers were investigated in vitro and in vivo. The particle size results showed that the organic solvent-impregnated rice bran meal dietary fiber (N-RBDF) had the smallest average particle size and the aqueous enzymatic rice bran meal dietary fiber (E-RBDF) had the narrowest particle size distribution. Scanning electron microscopy (SEM) results demonstrated that all three kinds of rice bran meal dietary fibers (RBDF) were irregularly flaky. Fourier transform infrared spectroscopy (FT-IR) results revealed that the three RBDFs had similar reactive groups, and X-ray diffraction (XRD) results indicated that all three RBDFs were cellulose type I crystals. The results of thermogravimetric analysis showed that the lignin content of N-RBDF was significantly lower than that of the other two. Among the three kinds of RBDFs, E-RBDF had higher water retention capacity, swelling capacity, oil holding capacity, and adsorption capacity for cholesterol and sodium bile salts. The results of experimental studies in hyperlipidemic rats showed that all three kinds of RBDFs significantly reduced triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and elevated high-density lipoprotein cholesterol (HDL-C) in serum of hyperlipidemic rats; they also significantly lowered malondialdehyde (MDA) and elevated total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities in liver of rats. In addition, all three kinds of RBDFs decreased aminotransferase (ALT) and aminotransferase (AST) activity in serum and also improved liver steatosis and reduced atherosclerosis index (AI) in rats with hyperlipidemia. Our study provides a reference for the development and utilization of rice bran meal and the application of rice bran meal dietary fiber in food processing.
Predictors of CPAP Adherence and Comparison of Clinical Factors and Polysomnography between Compliance and Non-compliance in Korean Adults with Obstructive Sleep Apnea
Authors: Cho Seo-Eun , Jung Joo Hyun , Kang Jae Myeong , Cho Min Young , Lee Yea Seol , Kang Seung-Gul , Kim Seon Tae
Published: May 2023

Continuous positive airway pressure (CPAP) is the treatment of choice for obstructive sleep apnea (OSA). However, compliance with CPAP varies from study to study, and studies on predictors of compliance with CPAP are insufficient in Korea. The aim of this study was to identify factors predicting compliance with CPAP therapy in patients with OSA. We retrospectively reviewed medical records, polysomnography (PSG) records, and self-report questionnaires of patients with OSA. Criteria for compliance was the use of CPAP devices for ≥ 4 h per night for ≥ 70% of the consecutive 30 nights (i.e., 21 days) during the first 3 months of treatment initiation. The patients were classified into two groups: compliant and non-compliant. Logistic regression analyses were performed to identify clinical factors and PSG parameters associated with compliance with CPAP. Among 188 participants, 80 were classified into the compliant group and 108 were classified into the non-compliant group. The ratio of stage N1 (P = 0.011) and health insurance coverage (P = 0.007) were significantly associated with compliance with CPAP, with an explanatory power of 18.6% (R2 = 0.186, P < 0.001). This study indicated that the stage N1 ratio and health insurance coverage were significant predictors of CPAP compliance. It is necessary to confirm whether the relationship between a high stage N1 ratio and compliance is reproduced in a larger sample and in individuals from other countries.
A Comparison of Ambient Air Ethylene Oxide Modeling Estimates from Facility Stack and Fugitive Emissions to Canister-based Ambient Air Measurements in the Salt Lake City
Authors: Spooner Skyler , Handy Rod , Daher Nancy , Edie Rachel , Henry Trent , Sleeth Darrah
Published: May 2023

Ethylene Oxide (EtO) is a colorless, flammable gas at room temperature, produced by the catalytic oxidation of ethylene. EtO is widely used by medical sterilization facilities to clean medical supplies and equipment. Recent epidemiological studies showed that EtO is a more potent carcinogen than previously documented, leading the Environmental Protection Agency (EPA) to update, in December 2016, the inhalation unit risk estimate for EtO. This resulted in the identification of EtO as a potential health concern in several areas across the US, including the state of Utah. The geography surrounding Salt Lake Valley creates a bowl; ideal for collecting air pollution emissions. The region often experiences inversion episodes which inhibit vertical mixing and cause an accumulation of air pollutants, leading to unhealthy pollution levels. Using the EPA's dispersion modeling software, AERMOD, this study estimated EtO concentrations through facility stack and fugitive emissions modeling results. These values were compared with those of canister-based concentrations from ambient air samples taken near a medical device sterilization facility in the Salt Lake Valley. Stainless steel, whole-air passivated canisters were used to collect 24-hour ambient concentration samples of EtO. Eight locations surrounding a Salt Lake Valley medical device sterilization facility and four background sites were chosen to measure the ambient concentrations. Accounting for potential atmospheric impacts on EtO, measurements were sampled in winter 2022 (January-March) and summer 2022 (July-September). The modeled EtO concentrations were adjusted to account for background values associated with the winter or summer data. Then the two methodologies were compared using a Wilcoxon Sign-ranked, paired test. The statistical analysis resulted in six of the eight sample locations surrounding the sterilization facility being significantly different when comparing canister-based measurements of ambient EtO to modeled estimates. Canister-based measurements taken at sites one, three, and four were statistically greater than the modeled estimates, while sites two, five, and seven were statistically less than the modeled estimates. Also, the summer background value calculated was almost 2.5 times greater than the winter. The results do not suggest whether one method is more or less conservative than the other. In conclusion, the five of the closest sites and site seven were statistically different when comparing measured and modeled ambient concentrations of EtO. The comparison results do not clearly indicate if a correction factor could be derived for future human exposure to cancer risk assessment modeling. However, it is reasonable that the closer to the sterilization facility, the more total EtO exposure will be realized.
Disruption of Mitochondrial Unfolded Protein Response Results in Telomere Shortening in Mouse Oocytes and Somatic Cells
Authors: Cozzolino Mauro , Ergun Yagmur , Ristori Emma , Garg Akanksha , Imamoglu Gizem , Seli Emre
Published: May 2023

Caseinolytic peptidase P (CLPP) plays a central role in mitochondrial unfolded protein response (mtUPR) by promoting the breakdown of misfolded proteins and setting in motion a cascade of reactions to re-establish protein homeostasis. Global germline deletion of Clpp in mice results in female infertility and accelerated follicular depletion. Telomeres, on the other hand, are tandem repeats of 5’-TTAGGG-3’ sequences found at the ends of the chromosomes. Telomeres are essential for maintaining chromosome stability during somatic cell division and their shortening is associated with cellular senescence and aging. In this study, we asked whether the infertility and ovarian aging phenotype caused by global germline deletion of Clpp is associated with somatic aging, and tested telomere length in tissues of young and aging mice. We found that impaired mtUPR caused by the lack of CLPP is associated with accelerated telomere shortening in both oocytes and somatic cells of aging mice. In addition, expression of several genes that maintain telomere integrity were decreased, and double strand DNA breaks were increased in telomeric regions. Our results highlight how impaired mtUPR can affect telomere integrity and demonstrate a link between loss of mitochondrial protein hemostasis, infertility, and somatic aging.
Exploring the Experiences of Non-Psychiatric Professional Nurses Regarding Care of MHCU’S with Medical Conditions in General Wards of Limpopo Province, South Africa
Authors: Letlalo Vusiwana Patricia , Maluleke Mary , Rangwaneni Mphedziseni Esther , Raliphaswa Ndidzulafhi Selina
Published: May 2023

Mental Health Care Users (MHCUs) are admitted in general wards with medical and surgical conditions where non-psychiatric nurses are allocated to render services for medical and surgical conditions. Non-psychiatric nurses are expected to care for MHCUs in general wards regardless of their knowledge and skills which is against the Mental Health Care Act. The purpose of the study was to explore and describe the experiences of non-psychiatric nurses in car-ing for MHCUs admitted in general wards in Limpopo Province. Qualitative approach using explorative, descriptive, and contextual design was adopted for the study. Methodology included the setting, population, sampling, ethical con-siderations, and the measures to ensure trustworthiness. The study was conducted in four general hospitals of Limpopo Province, South Africa with mental health care wards, medical ward and surgical ward which were selected through simple random sampling. Semi structured Individual interviews were used to collect data from twenty professional nurses until data saturation. Data was analysed using Tesch’ s method. Ethical considerations were adhered to throughout the study. Themes that emerged after data analysis were: Managing MHCUs, Types of patient’s behaviour. The study concluded that professional nurses without psychiatry caring for MHCUs in general wards need training to provide holistic care.
Molecular Mapping To Identify Stable Salinity-Resilient QTLs From the Novel Landrace Akundi in Two Bi-Parental Populations Using SNP-Based 1k-RiCA Genotyping in Rice
Authors: Maniruzzaman Sheikh , Rahman M. Akhlasur , Hasan Mehfuz , Rasul Golam Golam , Molla Abul Hossain , Khatun Hasina , Iftekharuddaula KM Md , Akter Salma
Published: May 2023

Achieving high-yield potential is always the ultimate objective of any breeding program. However, various abiotic stresses like salinity, drought, cold, flood, and heat hampered rice productivity tremendously. Salinity is one of the most important abiotic stresses that adversely affect rice grain yield. The present investigation was undertaken to dissect new genetic loci, which are responsible for salt tolerance at the early seedling stage in rice. A bi-parental mapping population (F2:3) was developed from the cross between BRRI dhan28/Akundi, where BRRI dhan28 (BR28) is a salt-sensitive irrigated (boro) rice mega variety and Akundi is a highly salinity tolerant Bangladeshi origin indica rice landrace that is utilized as a donor parent. We report stable QTLs for salt tolerance from a common donor (Akundi) irrespective of two different genetic backgrounds (BRRI dhan49/Akundi and BRRI dhan28/Akundi). A robust 1k-Rice Custom Amplicon (1k-RiCA) SNP marker genotyping platform was used to genotype this bi-parental population. After eliminating markers with high segregation distortion, 886 polymorphic SNPs built a genetic linkage map covering 1526.5 cM of whole rice genome with an average SNP density of 1.72 cM for the 12 genetic linkage groups. A total of 12 QTLs for nine different salt tolerance-related traits were identified using QGene and inclusive composite interval mapping of additive and dominant QTL (ICIM-ADD) under salt stress on seven different chromosomes. All of these 12 new QTLs found unique, as no other map from the previous study has reported these QTLs in the similar chromosomal location and found them different from extensively studied Saltol, SKC1, OsSalT and salT locus. Twenty-eight significant digenic/epistatic interactions identified between chromosomal regions linked to or unlinked to QTLs. Akundi acts like a new alternate donor source of salt tolerance except for other usually known donors like Nona Bokra, Pokkali, Capsule, and Hasawi used in salt tolerance genetic analysis and breeding programs worldwide, including Bangladesh. Integration of the seven novel and stable QTLs (qSES1, qSL1, qRL1, qSUR1, qSL8, qK8, qK1) reported in this investigation will expedite the cultivar development that is highly tolerant to salt stress.
Enhancing the Levelized Cost of Hydrogen with the Usage of the By-Product Oxygen in a Wastewater Treatment Plant
Authors: Hönig Franziska Maria , Rupakula Ganesh Deepak , Duque-Gonzalez Diana , Ebert Matthias , Blum Ulrich
Published: May 2023

In order to harmonize supply and demand of green energy, new future-proof technologies are needed. Here, hydrogen plays a key role. Within the current framework conditions, the production of green hydrogen is not yet economically viable. The use of the oxygen produced and the possible increase in efficiency associated with it mostly remains unconsidered. The aim is to demonstrate that the economic efficiency of a power-to-gas (PtG) project can be increased by using the by-product oxygen. In this research project, a water electrolyser connected to grid is powered to supply hydrogen to a hydrogen refuelling station. By utilising the by-product oxygen from water electrolysis for a wastewater treatment plant (WWTP), it is shown that the net present value (NPV) of the project can be improved by up to 13 % compared to the initial scenario. If a photovoltaic (PV) system is used in addition to grid electricity for higher green hydrogen production, the NPV can be further improved by up to 58 %. The levelized cost of hydrogen (LCOH) is calculated for different scenarios with and without oxygen configuration. A sensitivity analysis is then performed to find important parameters.
A Review on the Relation between European Protected Areas, Farming Systems and Certification/Labelling Schemes of Agri-Food Products with a Protected Area Logo
Authors: Koutsouki Athina , Nastis Stefanos , Bournaris Thomas , Zikos Dimitrios
Published: May 2023

European Protected Areas (PAs) are facing today complex and highly diverse challenges. Farm management structures have changed over time and traditional low-intensity farming systems have become unprofitable leading to either abandonment or intensification of farming practices. These changes have contributed to the environmental degradation of biodiversity rich agricultural landscapes and the loss of cultural knowledge and traditions. The interrelations developing at various levels between agricultural land use, nature and landscape conservation, and socio-economic activities influence the sustainable development and management of PAs. The development of certification and labelling schemes for high quality agri-food products with a PA logo is a rural development process that involves multiple functions which could generate environmental improvements and positive socio-economic changes. The differentiation of the agricultural products of PAs, through labelling and information, can be a proactive market-based instrument to support the local economy, promote environmentally sound practices, raise environmental awareness, and preserve farmland biodiversity in protected areas. This paper review is an attempt to gather and analyze in depth the findings of the existing studies focusing on the relationship between the European PAs, farming systems and certification/labelling schemes of agri-food products with a PA logo. Academic research on the subject is limited but provides valuable insights. The findings can serve as a starting point for discussions and reveal opportunities for further research to better understand the interrelations and additional effects emerging from the labelling/certification of PAs’ high quality agri-food products.
A Review on Isolation, Characterization, Modification, and Applications of Proso Millet Starch
Authors: Kumar Simmi Ranjan , Tangsrianugul Nuttinee , Suphantharika Manop
Published: May 2023

Proso millet starch (PMS) as an unconventional and underutilized cereal starch is becoming increasingly popular worldwide due to its health-promoting properties. This review summarizes research progress in the isolation, characterization, modification, and applications of PMS. PMS can be isolated from proso millet grains by acidic, alkaline, or enzymatic extraction. PMS exhibits typical A-type polymorphic diffraction patterns and shows polygonal and spherical granular structures with a granule size of 0.3-17 µm. PMS is modified by chemical, physical, and biological methods. The native and modified PMS are analyzed for swelling power, solubility, pasting properties, thermal properties, retrogradation, freeze-thaw stability, and in vitro digestibility. The improved physicochemical, structural, and functional properties and digestibility of modified PMS are discussed in terms of their suitability for specific applications. The potential applications of native and modified PMS in food and non-food products are presented. Future prospects for research and commercial use of PMS in the food industry are also highlighted.
Nanometric and Thermogravimetric Evaluation of Volcanic Clays With Industrial Interest (Ecuador)
Authors: CERON IGNACIO BLADIMIR , Ceron Maria Jose , Loria Luis Guillermo , Salvador Marcelo , Lemos Cristian , Saenz Giovanni
Published: May 2023

Ecuador has 4000 Km2 of volcanic nanoclay reserves that could be industrialized. An immediate application is to modify the local AC-20 asphalt with this aggregate. This resource was characterized with FTIR, XRD, FRX, SEM, BET, Laser Granulometry, SPECMIN, TSG, TGA, DTG, DSC and Atmospheric Adsorption. FTIR showed vibration peaks Si and Al. X-ray diffraction indicated the presence of silicates and alumina, BET measured particle size (30 to 250 nm), and the SSA property measured the specific surface area (280.38 m2/g). Chip rock (natural clay) was treated with H2O2 or NaOH or NH3 and evaluated with SPECMIN -TSG obtaining spectra close to vermiculite, allophane and bentonite minerals. At 1000 °C additional samples were calcined in Thermogravimetry (TGA), Differential Thermogravimetry (DTG), Differential Thermal Analysis (DCS), with mass loss around 40%, corresponding to organic matter, hydroxyl (OH) and destruction of its structure with spicule formation at 956 °C. With the DSC there were endothermic and exothermic manifestations. The Si/Al layers would have micro and meso porosity, it was also found to be a nanoparticulate material, with high adsorption capacity. At temperatures above 350 °C, its structure collapsed. Thus, this synthesized nanoclay will be used as an additive to form new materials.
Twisted Silica Few-Mode Hollow GeO2-Doped Ring Core Microstructured Optical Fiber
Authors: Bourdine Anton V. , Demidov Vladimir V. , Ter-Nersesyants Egishe V. , Pchelkin Grigori A. , Shurupov Dmitriy N. , Khokhlov Alexander V. , Matrosova Alexandra S. , Kashin Andrey I. , Bureev Sergei V. , Dashkov Michael V. , Evtushenko Alexander S. , Zaitseva Elena S. , Gizatulin Azat R. , Meshkov Ivan K. , Dyavangoudar Amogh A. , Saharia Ankur , Tiwari Manish , Vasilets Alexander A. , Elagin Vasiliy S. , Singh Ghanshyam , Dukelskii Konstantin V.
Published: May 2023

This work presents first time successfully fabricated silica few-mode microstructured optical fiber (MOF) with hollow GeO2-doped ring core and strongly induced twisting up to 790 revolutions per meter. Some technological issues for manufacturing of GeO2-doped supporting elements for large hollow cores as well as described above complicated spun MOFs are discussed. We introduce some results of tests, performed for pilot samples of designed and manufactured described above untwisted and twisted MOFs with outer diameter 65 µm and hollow ring core inner diameter 30.5 µm under wall thickness 1.7 µm and refractive index difference n=0.030, including their geometrical parameters, basic transmission characteristics and measurements of far-field laser beam profile patterns.
Evaluation of Five Mammalian Models for Human Disease Research Using Genomic and Bioinformatic Approaches
Authors: Jagadesan Sankarasubramanian , Mondal Pinaki , Carlson Mark A , Guda Chittibabu
Published: May 2023

The suitability of an animal model to study human diseases heavily relies on the similarity between the two species at the genetic, epigenetic, gene expression and metabolic levels. However, consistent data from different animal models at each level to evaluate this suitability is lacking. With the availability of genome sequences for many mammalian species it is now possible to compare animal models based on the genomic similarities. Here, we compare the coding sequences (CDS) of five mammalian models that include rhesus macaque, marmoset, pig, mouse and rat with those from human. We identified 10,316 conserved CDS across the five organisms and human based on the sequence similarity. Mapping the human disease-associated single nucleotide polymorphisms (SNPs) from these conserved CDS in each species has identified species-specific association with various human diseases. While associations for a disease such as colon cancer were prevalent in multiple model species, pig showed the highest number (117 diseases) of model-specific human disease associations. Based on the percentage of disease-associated SNP-containing genes, marmoset models are well suited to study many human ailments including behavioral and gastrointestinal diseases. Comparison of gene expression levels of the conserved CDS from colon, heart, kidney, lung, skeletal muscle, and spleen tissues in these models showed correlations with human expression levels in a tissue-specific manner. In the gastrointestinal tissues (colon, spleen), the pig showed the highest correlation while mouse displayed a better correlation in the heart and kidney. This study demonstrated genomic as well as tissue-specific expression-based similarity evaluation of five animal models against human that could help investigators select a suitable animal model to study their targeted disease.
Распространение вариантов вируса SARS-COV-2, вызывающих интерес (VOI) и субвариантов Omicron, находящихся под наблюдением (VUM), на основе количества их геномов, депонированных в базу данных GISAID за неделю с 20.05.2023 г. по 26.05.2023 г.
Authors: Чумачкова Елена , Краснов Ярослав , Дмитриева Людмила , Осина Наталия , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: May 2023

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 вызывающих интерес (VOI) и субвариантов Omicron, находящихся под наблюдением (VUM), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 20 по 26 мая 2023 г.
Management of High-Energy Tibial Pilon Fractures
Authors: Murawski Christopher D. , Mittwede Peter N. , Wawrose Richard A. , Belayneh Rebekah , Tarkin Ivan S.
Published: May 2023

➤ Pilon fractures in the younger patient population are frequently high-energy, intra-articular injuries and are associated with devastating, long-term impacts on patient-reported outcomes and health-related quality of life, as well as high rates of persistent disability.

➤ Judicious management of associated soft-tissue injury, including open fractures, is essential to minimizing complications. Optimizing medical comorbidities and negative social behaviors (e.g., smoking) should be addressed perioperatively.

➤ Delayed internal fixation with interval temporizing external fixation represents the preferred technique for managing most high-energy pilon fractures presenting with characteristically substantial soft-tissue trauma. In some cases, surgeons elect to utilize circular fixation for these scenarios.

➤ Although there have been treatment advances, the results have been generally poor, with high rates of posttraumatic arthritis, despite expert care.

➤ Primary arthrodesis may be indicated in cases with severe articular cartilage injury that, in the opinion of the treating surgeon, is likely unsalvageable at the time of the index management.

➤ The addition of intrawound vancomycin powder at the time of definitive fixation represents a low-cost prophylactic measure that appears to be effective in reducing gram-positive deep surgical site infections.
Architectural survey of eight Ohio Army National Guard armories, 1971–1977
Authors: Adams Sunny , Story Madison
Published: May 2023

This document is an architectural survey of eight armories, seven field maintenance shops (FMS; three detached and four attached to the armory), and ten metal storage buildings utilized by the Ohio Army National Guard (OHARNG), located across the state of Ohio. The armories and OMS were constructed or received extensive renovation and additions between 1971 and 1977, while the majority of the metal storage buildings were constructed in the 1980s. This survey satisfies Section 110 of the National Historic Preservation Act of 1966 (NHPA) as amended and was used to recommend the eligibility of these buildings and structures for inclusion on the National Register of Historic Places (NRHP). It is the recommendation of this report that two armories; Alliance Armory (1976) and Xenia Armory (1975) and one associated support building; Xenia motor storage building (1975) are significant under National Register of Historic Places criteria and retain enough integrity to be individually eligible for the NRHP. Volume II of this report is published separately and contains the ERDC-CERL architectural survey forms.
Analysis of the Interests of the Nologaten Village Community in Using Sharia Bank Products in Ponorogo
Authors: Saputra Rizaldi Nur , Janah Unun Roudlotul
Published: May 2023

The community is interested in using Islamic bank products due to several factors that influence it. The Nologaten Village community with all its limitations, stated several reasons that caused their low interest in Islamic banks. The most dominant factors in this case are knowledge, product, location, environment and religiosity factors. The formulation of the problem in this case is how the interest of the Nologaten Village Community in using Islamic bank products is seen from these five factors. This study aims to determine how the interest of the people of Kelurahan Nologaten in using Islamic banks is seen from the five factors. The research used is a qualitative research with data obtained from the community of Nologaten Village using the source triangulation method, by combining data collection with observation and interview techniques. The data analysis technique used in this research is data analysis in the field using the Miles and Huberman model, namely data collection, data reduction, data presentation and the last step is drawing conclusions. The results of this study indicate that the five factors influence the interest of the people of Kelurahan Nologaten in using Islamic banks. The factors of the lack of knowledge of the people of Nologaten Village about Islamic banks, the lack of interest in the Nologaten Village of products offered by Islamic banks, the uneven development of Islamic banking locations that stand in Ponorogo City, as well as environmental factors and the religiosity of the Nologaten Village community that are not compatible with Islamic banks make the Nologaten Village community's interest in using banks sharia is low.