bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review
Authors: Wang Yao , Zhu Qing , Chen Ailin , Dai Chungang , Xu Longjiang , Sheng Minfeng , Huang Qiang , Lan Qing , Mu Qingchun , Li Rujun
Published: November 2024

Introduction

The incidence of hemangioblastoma is low, constituting only 1-5% of all spinal cord tumors. Specifically, intradural extramedullary hemangioblastoma without Von Hippel-Lindau syndrome represents an exceedingly rare condition.

Methods

We report the first documented case of cervical intradural extramedullary hemangioblastoma in China. A 53-year-old male patient presented with a 3-year history of mild right hemiplegia, segmental muscle strength and sensation impairment, and a positive pyramidal tract sign. MRI showed an abnormal oval signal focus in the intradural and extramedullary region at the C6-C7 vertebral level. Before surgery, angiography was performed to identify the supplying arteries and draining veins. Subsequent interventional therapy achieved over 90% occlusion of blood vessels, creating optimal conditions for complete resection of the spinal tumor.

Results

The patient demonstrated satisfactory postoperative recovery with significant restoration of sensory and motor functions. Pathological examination showed a significant upregulation of CD31 in tumor cells and a substantial presence of the neuro-specific marker S100 in the tumor stroma, consistent with the diagnostic criteria for spinal hemangioblastoma.

Conclusion

The rarity of cervical intradural extramedullary hemangioblastoma without Von Hippel-Lindau syndrome was reaffirmed by a comprehensive review of the existing literature. Complete tumor resection remains the optimal approach for managing this uncommon condition, generally resulting in a favorable prognosis. Traditional open fenestration surgery is linked to elevated risks of bleeding and trauma. Meanwhile, endovascular injection of embolic agents may lead to residual lesions and an increased risk of recurrence. Therefore, we recommend a one-time combined treatment conducted in a hybrid operating room to achieve complete resection and effectively reduce intraoperative bleeding risk. Despite presenting challenges and requiring high proficiency, we still recommend this type of combined surgery as a suitable therapeutic option for such diseases.
Causes of death after oral cancer diagnosis: a population based study
Authors: Jiang Zhenyu , Shao Li , Zhou Jie , Shao Xuwen , Shen Chao
Published: November 2024

Background

Nowadays, the number of oral cancer survivors is increasing, emphasizing the importance of thoroughly understanding diverse causes of death in oral cancer survivors. Our study aimed to investigate the distribution of causes of death after oral cancer diagnosis.

Methods

Eligible patients were identified between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. We calculated the number of deaths in different demographic and clinicopathological variables during each follow-up period. Standardized mortality ratios(SMRs) were generated for each cause of death after oral cancer diagnosis.

Results

A total of 30538 patients diagnosed with oral cancer were included, and 17654 deaths were reported during follow-up period. 27.08% of deaths were caused by non-caner reasons. The proportion of non-cancer related deaths increased with the extension of survival time, and non-cancer death accounted for 57.93% of all deaths when followed up more than 10 years. The most common non-cancer cause of death was cardiovascular disease (SMR 4.68#; 95%CI 4.46-4.92).

Conclusions

Non-cancer causes of death should not be ignored in oral cancer patients. For oral cancer survivors, multidisciplinary follow-up strategy should be recommended to achieve longer survival time.
Engaging children and adolescents in the design and conduct of paediatric research
Authors: Bierer Barbara E. , Koppelman Elisa , Croker Alysha K. , Hosseinzadeh Sharareh , Hovinga Collin , Joffe Steven , McMillan Gianna , Nelson Robert , Bucci-Rechtweg Christina
Published: November 2024

The importance of patient engagement in product development and clinical research is widely acknowledged. In pediatrics, parents and guardians are often vocal advocates for their children in the process, but investigators and sponsors rarely directly solicit children's or adolescents’ perspectives in clinical research planning or as patient partners during the conduct of research. Here, we provide compelling reasons and recommendations for investigators and sponsors to systematically engage young people in the design, conduct, and review of research, and the premise that input will be incorporated as a routine expectation. We consider the theoretical, ethical, and practical implications of this approach.
Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide
Authors: Llanes Dayma , Rennert Robert , Jänicke Paul , Morgan Ibrahim , Reguera Leslie , Rivera Daniel G. , Ricardo Manuel G. , Wessjohann Ludger A.
Published: November 2024

Peptide-drug conjugates (PDCs) have recently gained significant attention for the targeted delivery of anticancer therapeutics, mainly due to their cost-effective and chemically defined production and lower antigenicity compared to ADCs, among other benefits. In this study, we designed and synthesized novel PDCs by conjugating new thiol-functionalized tubulysin analogs (tubugis) to bombesin, a peptide ligand with a relevant role in cancer research. Two tubulysin analogs bearing ready-for-conjugation thiol groups were prepared by an on-resin multicomponent peptide synthesis strategy and subsequently tested for their stand-alone in vitro anti-proliferative activity against human cancer cells, which resulted in IC50 values in the nanomolar range. In addition, various fluorescently labeled [K5]-bombesin(6–14) peptides, non-lipidated and lipidated with fatty acid chains of variable length, were also synthesized using the versatile multicomponent chemistry. These bombesin derivatives were tested for their gastrin-related peptide receptor (GRPR)-mediated internalization into cancer cells using flow cytometry, proving that the lipid tail (especially C14) enhances the cell internalization. Using the tubugi toxins and bombesin peptides, three different bombesin-tubugi conjugates were synthesized with different cleavage propensity and lipophilicity. Preliminary in vitro experiments revealed that, depending on the linker and the presence of a lipid tail, these novel PDCs possess good to potent anticancer activity and moderate selectivity for GRPR-overexpressing cancer cells.
Effects of Kalimeris indica on alcohol-induced liver injury through storing Nrf2/HO-1 pathway and gut microbiota
Authors: Wang Mo-Fei , Sun Tong , Chen Shi-Yu , Wang Xue , Li Hao , Wang Jia-Qi
Published: November 2024

Background

Kalimeris indica (L.) Sch. Bip., (K. indica) is a plant classified under the genus Kalimeris within the Asteraceae family. The herb of K. indica has been historically utilized as a traditional medicine. The consumption of excessive amounts of alcohol represents a lifestyle choice that can induce tissue damage and contribute to the development of various health conditions.

Method

The HPLC-MS method was used to reveal the chemical composition of K. indica extract. HepG2 cells were used to test the in vitro oxidative stress. C57BL/6 mice were used to construct the in vivo alcohol-induced liver injury. H/E staining and serum ALT and AST levels were tested to assess the in vivo protective effect of ML (50 and 200 mg/kg). GSH, SOD, and CAT levels along with byproduct MDA levels were used to evaluate the in vivo oxidative stress. Immunohistochemical experiments were used to examine the in vivo Nrf2 and HO-1 levels. 16S rRNA gene-based profiling method was used to test the alteration in gut microbiota.

Results

16 compounds were identified from K. indica extract. K. indica treatment reduced oxidative stress in HepG2 cells treated with 5% alcohol. H/E staining results showed that K. indica (50 and 200 mg/kg) alleviated liver injury caused by alcohol administration, eliciting a similar protective effect to the positive drug silymarin. Serum ALT and AST examination gave a consistent result, showing that ML could restore serum ALT and AST levels in mice treated with alcohol. Furthermore, K. indica could also restore GSH, SOD, CAT, and MDA levels in alcohol-treated mice, showing a potent effect on oxidative stress alleviation. Immunohistochemical experiments indicated that K. indica showed the liver protective effect through Nrf2/HO-1 pathway. 16S rRNA gene-based profiling revealed that alcohol treatment caused the alteration in gut microbiota, while K. indica treatment could result in a significantly richer variety of microbial communities compared to the alcohol group.

Conclusion

K. indica (ML) has a protective effect on liver injury caused by alcohol administration. The Nrf2/HO-1 pathway and gut microbiota regulation were involved in the ML-induced liver protection. All the results indicate that K. indica has a potential in the treatment of alcohol-induced liver injury.
Discrepancy in coordination and variation of root and leaf traits among herbaceous and shrub species in the desert, China
Authors: Ma Jing , Wang Taotao , Wang Hongyong , Chen Yiming , Yang Jie , Xie Tingting , Shan Lishan
Published: November 2024

Introduction

Alterations in life forms could simultaneously influence the variability of fine root and leaf traits. However, our understanding of the organ-level coordination and patterns of variation in fine root and leaf traits among desert herbs and shrubs with distinct habits remains limited.

Methods

Consequently, this study examined the leaf and fine root traits of 9 shrubs and 9 herbs across three desert habitats through Sperman's correlation analysis, principal component analysis (PCA), and standardized major axis (SMA) analysis as a means of identifying the hub traits and the resource trade-off strategies employed by desert plants to adapt to their environment.

Results

The results showed that the extent of coordination between leaf and root traits, defined as similarity, was contingent upon the life form. While the traits in shrubs were completely decoupled, those in herbs exhibited a high degree of coordination. The traits related to water acquisition and storage are highly connected and do not depend on traits and life forms. Most leaves and fine roots were primarily loaded along the PC1 and PC2 axes of principal component analysis.

Discussion

Suggesting that herbs and shrubs each adopt the most advantageous trait syndrome in accordance with their life form to acquire and conserve resources. The leaf economic spectrum and the root economic spectrum evolved independently, showing no dependence on the variations in life form. In conclusion, in desert plants, leaf and root variations occur independently along two axes, with traits associated with water acquisition playing a neutral role in their ecological strategy.
Indole-3-acetic acid treatment promotes postharvest kiwifruit softening by regulating starch and cell wall metabolism
Authors: Guan Wenhao , Cao Mengze , Chen Wei , Yang Zhenfeng , Li Xuewen , Wang Li , Shi Liyu
Published: November 2024

The softening process of postharvest kiwifruit is a critical aspect of fruit quality that has been extensively studied. However, the impact of indole-3-acetic acid (IAA) treatment on this process remains largely unexplored. In this study, we examined the effect of IAA treatment on the softening of postharvest kiwifruit. The results depicted that kiwifruit treated with IAA exhibited decreased firmness and increased ethylene production. Treatment with IAA upregulated the expression of starch decomposition genes, including AcSEX and AcBAM, resulting in a reduction in starch content. Additionally, IAA treatment induced cell wall breakdown, attributed to the enhanced transcript levels of cell wall-related degradation genes such as AcPE, AcPG, AcPL, and AcCX compared to the control. Consequently, IAA-treated kiwifruit displayed lower levels of cellulose and protopectin but higher levels of water-soluble pectin. In summary, our findings indicate that exogenous IAA promoted postharvest starch and cell wall biodegradation in kiwifruit, which reduced fruit firmness and accelerated fruit softening.
The influence of physical exercise on negative emotions in adolescents: a meta-analysis
Authors: Wang Tong , Li Weicheng , Deng Jiaxin , Zhang Qiubo , Liu Yongfeng
Published: November 2024

Background

Adolescence is also accompanied by ongoing mood changes (relative to childhood and adulthood), which can trigger more extreme negative emotional responses. Physical exercise alleviates negative emotions and reduces the risk of mental illness. However, the effect of physical exercise on negative emotions in adolescents is unclear, so it is valuable to synthesize previous studies with meta-analysis.

Objective

To examine the influence of physical exercise (PE) intervention on negative emotions in adolescents aged 10 to 19 years.

Methods

We retrieved the articles from PubMed, Web of Science, EBSCO, Cochrane, and Embase up to April 11, 2024. The main search terms were physical exercise, negative emotions, adolescents, randomized controlled trials. The meta-analysis was conducted using Review Manager 5.3. A random-effects model was employed to calculate the standardized mean difference (SMD) and 95% confidence interval (CI). Subgroups were analysed as the type of negative emotions, type of control group, intervention type, duration, time, frequency.

Results

The PE intervention group exhibited a significantly superior improvement in alleviating negative emotions compared to the control group (SMD = -0.59, 95% CI: -0.92 to -0.26, p < 0.01, Z = 3.50, I² = 95%). PE was particularly effective in mitigating adolescent depression (SMD = -0.67, 95% CI = -1.07 to -0.28, p < 0.01, I² = 96%) but did not yield significant results in reducing adolescent anxiety (SMD = -0.29, 95% CI = -0.63 to 0.05, p = 0.10, I² = 95%).

Conclusion

PE intervention can ameliorate negative emotions in adolescents.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42024534375.
Intergenerational crosstalk of brain-gut axis in parental Nd2O3 exposure-induced offspring neurotoxicity and cognitive dysfunction: a mechanistic study
Authors: Jia Yujing , Cao Jing , Guo Yan , Wu Lihong , Du Xiaoyan , Tang Bofu , Xia Bingtao , Deng Yang
Published: November 2024

Introduction

Rare earth elements (REEs) are widely used in plenty of fields. REEs have significant neurotoxicity and it may adversely affect the development of cognitive. For example, neodymium will causing neurological damage through penetrate the blood–brain barrier (BBB). However, whether it disrupts the balance of brain-gut axis (BGA) crosstalk and affects the intestinal microecology disorder of host is still unclear. This study investigated the neural damage on children caused by maternal exposure to Neodymium oxide (Nd2O3) during pregnancy, and its involved mechanism of BGA injury.

Methods

We used rat model to investigated the mechanisms of the offspring’s neural damage that Nd2O3 exposure in pregnancy. To verify the neural damage of offspring rats, we examed BBB-related factors, such like glutamate and ROS levels in brain tissue, behavioral tests, hippocampal and cortical damage, as well as changes in gut microbiota, intestinal mucosal barrier, and SCFAs in the intestine. Also, we observed some specific indicators of intestinal immune barrier function and gut nerve-related indicators.

Results

Maternal Nd2O3 exposure reduced the content of offspring tight junction proteins, increased BBB permeability, leading to Nd accumulation and brain tissue inflammation, affecting offspring’s neural development and weakening their spatial learning ability. Nd2O3 also disrupted BBB integrity by regulating SCFAs and BGA. Probiotic intervention in the offspring rats exposed to 2% Nd2O3 showed significant recovery of inflammation in both brain and colon tissues, and reduced BBB permeability.

Conclusion

Maternal exposure to Nd2O3 affects the offspring’s BGA, targeting brain and colon tissues, increasing BBB permeability, affecting neural development, causing damage to the intestinal mucosa, and impacting children’s gut development. Probiotics can alleviate these effects. These findings provide valuable insights into understanding the neurodevelopmental and intestinal developmental toxicity of Nd2O3 and its prevention and treatment. It also calls for a comprehensive assessment of the health risks of susceptible populations to Nd2O3, such as pregnant women. It may providing theoretical basis for preventing and controlling neodymium-induced harm in children by examing the repair mechanism of the damage through probiotic intervention.
Ibuprofen encapsulation inside non-conventional O/W Pickering emulsions stabilized with partially hydrophobized silica
Authors: Ramos Diego , Sapin-Minet Anne , Marchal Philippe , Parent Marianne , Sadtler Véronique , Roques-Carmes Thibault
Published: November 2024

The encapsulation of active ingredients is an important process in various industrial sectors including pharmaceutics, foods and cosmetics. For the first time, the capacity of non-conventional anti-Bancroft oil-in-water Pickering emulsions stabilized by partially hydrophobized silica to encapsulate an apolar active is addressed. A dispersed phase volume of paraffin oil of 50% coupled to 0.5 wt.% of silica has been employed to avoid excess of silica in the continuous phase and encapsulate higher amount of ibuprofen (the model drug). Three ibuprofen contents ranging from 100 mg (1.6 mg/mL of paraffin) to 420 mg (6 mg/mL of paraffin) have been tested. The encapsulation efficiency as well as the emulsions properties are investigated by the means of light diffusion, microscopy, rheology, and HPLC coupled to mass balance. The Pickering emulsion is very efficient for the encapsulation of ibuprofen with encapsulation rates of 99% obtained inside droplets of 30 µm for all the 3 ibuprofen concentrations. This encapsulation ability is perfectly maintained, whether during ageing (during 90 days), or when the emulsion is diluted by a factor 100 inside physiological media at basic and acidic pH.
Navigating uncertainty and negotiating trust in judicial deliberations
Authors: Bergman Blix Stina , Törnqvist Nina
Published: November 2024

Autonomy and independence are key features of legal decision-making. Yet, decision-making in court is fundamentally interactional and collective, both during the information gathering phase of hearings, and in evaluations during deliberations. Depending on legal system and type of court, deliberations can include different constellations of lay judges, jurors, or judge panels. In this article, we explore the collective dynamic of knowledge acquisition in legal decision-making, by analysing their emotional undercurrents. We show how judges balance uncertainty and certainty in legal deliberation, elaborating on (1) trust; (2) uncertainty exchange, and; (3) certainty as an agile emotion. Theoretically, the article combines an emotive-cognitive judicial framework, which understands emotion and reason as intersecting and continuous, with social interactionist theory. The analysis builds on extensive ethnographic fieldwork in Sweden, including shadowing and interviews with judges as well as observations during court proceedings and deliberations. The article actualizes the joint accomplishment of legal independence, and contributes with a nuanced account of how the decision-making process unfolds in legal deliberations.
The effect of lumbar multifidus muscle degeneration on upper lumbar disc herniation
Authors: Wang Bingwen , Xu Lifei , Teng Peng , Nie Lin , Yue Hongwei
Published: November 2024

Purpose

This study aimed to investigate the effect of lumbar multifidus muscle (MF) degeneration on upper lumbar disc herniation (ULDH).

Methods

This study used 3.0T magnetic resonance imaging (MRI) T2 axial weighted images to retrospectively analyze 93 ULDH patients and 111 healthy participants. Sixty-five pairs of participants were included in this study using propensity score matching (PSM). Cross-sectional area, fat infiltration area, anteroposterior diameter (APD), lateral diameter (LD), cross-sectional area of the bilateral multifidus muscles at the corresponding level, intervertebral disc area at the corresponding section, and visual analog scale (VAS) score for low back pain (LBP). For inter-group comparisons, we used the t-test, analysis of variance (ANOVA), Mann–Whitney U test, Kruskal–Wallis test, chi-square test, or Fisher's exact test, according to the type of data. We used Pearson correlation analysis to study the correlation between the VAS score and related indicators, and established a predictive model for upper lumbar disc herniation using the receive operative characteristic (ROC) curve analysis method. Finally, univariate and multivariate logistic regression analyses were performed to establish a predictive model for the risk of high lumbar disc herniation.

Results

We compared the fat areas at the lumbar vertebral levels L1/2, L2/3, and L3/4, as well as the left lateral diameter (LD) (MF), L1/2 left lumbar multifidus muscle index (LMFI), and L1/2 total fat infiltration cross-section area (TFCSA), and found significant differences between the case and control groups (P < 0.001). Furthermore, we observed a significant positive correlation (P < 0.05) between the VAS scores and multiple muscle indicators. Additionally, we developed ROC prediction models to assess the risk of lumbar intervertebral disc protrusion at the L1/2, L2/3, and L3/4 levels, with the results identifying L1/2 TFCSA, L2/3 TFCSA, and L3/4 relative psoas major muscle cross-section area (rPMCSA) as the most predictive indicators. Finally, univariate and multivariate logistic regression analyses showed that the L1/2 rPMCSA, L2/3 TFCSA were significantly associated with the risk of lumbar intervertebral disc protrusion in both models.

Conclusion

Degeneration of the MF is significantly correlated with the occurrence of ULDH, and the larger the area of fat infiltration in the MF, the more obvious the lower back pain in ULDH patients. In addition, TFCSA can serve as an indicator of the occurrence of ULDH.
Long term outcomes from the early days of minimally invasive thymoma surgery for Myasthenia Gravis patients: a follow-up of 19 years
Authors: Kaba Erkan , Özkan Berker , Kakuturu Jahnavi , Yardımcı Eyüp Halit , Erdoğdu Eren , Çimenoğlu Berk , Duman Salih , Toker Alper
Published: November 2024

Background

Long-term survival outcomes are crucial for accurately determining the effectiveness of treatment in an indolent disease like thymoma. We aimed to analyze the clinical findings in terms of survival and relapse patterns with a median follow up of 105 months (8.7 years) in patients with thymoma and myasthenia gravis who underwent minimally invasive surgery between 2002 and 2015.

Methods

A total of 59 pathologically confirmed Masaoka Stage I and II thymoma patients with Myasthenia Gravis (MG) who underwent minimally invasive thymoma resection were included in this study. Primary aim of this study is to evaluate recurrences, overall and disease free survival in patients with a thymoma and MG in the long run. We also aimed to study the changes in Myasthenia Gravis medication during the follow-up.

Results

The mean age of the patients was 47.6 +/13.5 years. Seventeen patients were at Masaoka Stage I and 42 were at Masaoka Stage II. The median follow-up time was 105 months. The mean size of the tumor was 3.6 cm +/16.2 cm. Twenty-one patients (35%) received adjuvant radiotherapy. There was no postoperative mortality and median length of hospital stay was 4 days. Two patients developed recurrences both presented with pleural metastases. Eight patients died because of non-oncologic pathologies. 10-year disease free survival and overall survival rates were calculated to 96.6% and 86.4% respectively.

Conclusion

The 10-year survival analysis and current myasthenic status of stage I-II thymoma patients with myasthenia gravis who underwent minimally invasive surgery demonstrate that these procedures are both safe and effective.
Nanoparticle containing recombinant excretory/secretory-24 protein of Haemonchus contortus enhanced the cellular immune responses in mice
Authors: Hasan Muhammad Waqqas , Haseeb Muhammad , Gadahi Javaid Ali , Ehsan Muhammad , Wang Qiangqiang , Lakho Shakeel Ahmed , Haider Ali , Aleem Muhammad Tahir , Aimulajiang Kalibixiati , Lu Mingmin , Xu Lixin , Song Xiaokai , Li Xiangrui , Yan Ruofeng
Published: November 2024

Haemonchus contortus poses a global challenge as a parasite affecting small ruminants, yet the problem of absence of an effective vaccine against H. contortus infection still exists. This investigation sought to appraise the immunological reaction induced by recombinant H. contortus excretory/secretory-24 (rHcES-24) in combination with complete Freund’s adjuvant (CFA) and bio-polymeric nanoparticles (NPs) within a murine model. In this study, rHcES-24 was encapsulated in poly(d, l-lactide-co-glycolide) (PLGA) and chitosan (CS) NPs, administered subcutaneously to mice. Researchers analyzed the NPs using scanning electron microscope (SEM) and assessed lymphocyte proliferation, specific antibodies, cytokines, T cell proliferation (CD3e+CD4+, CD3e+CD8a+), and phenotypic alteration in splenocytes (CD11c+CD83+, CD11c+CD86+) through flow cytometry to understand the immune response. The results demonstrated that the administration of nanovaccines (NVs) prompted immune responses towards Th1 pathway. This was indicated by notable enhancements in the production of specific antibodies, heightened cytokine levels, and a robust proliferation of lymphocytes observed in mice that received the NVs compared to control groups. Remarkably, mice vaccinated with the antigen-loaded NPs formulations exhibited considerably higher proportions of splenic dendritic cells (DCs) and T cells in comparison to those receiving the traditional adjuvant or the control groups. Incorporating HcES-24 protein into NPs effectively conferred immunity against H. contortus, paving the way for developing a targeted and commercial vaccine.
Construction methods and latest applications of kidney cancer organoids
Authors: Li Zhiqiang , You Yanqiu , Feng Bingzheng , Chen Jibing , Gao Hongjun , Li Fujun
Published: November 2024

Renal cell carcinoma (RCC) is one of the deadliest malignant tumors. Despite significant advances in RCC treatment over the past decade, complete remission is rarely achieved. Consequently, there is an urgent need to explore and develop new therapies to improve the survival rates and quality of life for patients. In recent years, the development of tumor organoid technology has attracted widespread attention as it can more accurately simulate the spatial structure and physiological characteristics of tumors within the human body. In this review, we summarize the main methods currently used to construct kidney cancer organoids, as well as their various biological and clinical applications. Furthermore, combining organoids with other technologies, such as co-culture techniques and microfluidic technologies, can further develop organoids and address their limitations, creating more practical models. This approach summarizes the interactions between different tissues or organs during tumor progression. Finally, we also provide an outlook on the construction and application of kidney cancer organoids. These rapidly evolving kidney cancer organoids may soon become a focal point in the development of in vitro clinical models and therapeutic research for kidney cancer.
Chemical Recycling of Epoxy Thermosets: From Sources to Wastes
Authors: Zhang Shuhan , He Enjian , Liang Huan , Yang Zhijun , Wang Yixuan , Yang Zhongqiang , Gao Chao , Wang Guoli , Wei Yen , Ji Yan
Published: November 2024

As one of the most widely used thermosets due to its excellent performances, epoxy resin (EP) is widely used in various fields and often employed as a component of composite actuator devices, strengthening their mechanical properties. However, the expanding production of EP inevitably leads to the accumulation of waste end-of-life equipment and the corresponding increasingly serious environmental problems. This review summarizes the recycling strategies of EP, divided into two perspectives: recycling from wastes and sources. Chemical recycling is expected to be the future of waste EP treatment, and we discuss the chemical recycling methods of existing waste EP based on different mechanisms, including the selective cleavage of ester bonds, C–N bonds, and C–O bonds. On the other hand, epoxy vitrimer networks based on various dynamic covalent linkages are also outlined, which can respond to multiple external stimuli and provide materials with recyclability from the origin. Therefore, the use of epoxy vitrimer actuators can prevent waste generation throughout the whole lifecycle. We present some issues of concern in both waste-based and source-based recycling strategies and emphasize the significance of scaling-up. Finally, we summarized the current situation and present some future perspectives with the aim of making practical contributions to environmental issues.
An Anti-Interference Control Algorithm for Continuum Robot Arm
Authors: Liu Hongwei , Meng Qianyi , Wang Junlei
Published: November 2024

The large number of joints in a continuum manipulator complicates its dynamic modeling, making model simplification inevitable for practical motion control. However, due to external disturbances and internal noise, a controller based on the simplified dynamic model often struggles to meet the desired dynamic performance. To address this issue, this paper proposes an anti-interference control algorithm for continuum manipulators, designed to compensate for parameter uncertainties, external disturbances, and measurement noise. At the same time, the parameters of the algorithm are obtained in the form of solvability of linear matrix inequalities (LMIs). The simulation results show that the algorithm proposed in the paper provides better transient performance and is not affected by the entire disturbance. Experimental results further confirm the effectiveness and robustness of the algorithm.
Design, Modeling, and Characteristics Analysis of Halbach Permanent Magnetic Spring
Authors: Lou Yuexuan , Zhang He , Cai Haoran
Published: November 2024

Magnetic springs, which can be used to replace traditional mechanical springs, have many advantages, such as necessitating no physical contact, generating no friction, no vibration or noise, and having a long lifespan. Nevertheless, their strong nonlinearity limits their widespread application. In this study, we developed a novel permanent magnet spring to address this issue: a Halbach permanent magnetic spring, with a large levitation force and an approximately linear force characteristic curve. First, we introduce the structure and the parameters of the Halbach permanent magnetic spring. Second, we describe the levitation force performance and the stiffness performance of the Halbach permanent magnetic spring using finite element analysis. Third, we analyze the trends through which different parameters influence the levitation force performance and stiffness performance. Finally, we provide recommendations for the future design of and improvement in the Halbach permanent magnetic spring.
Business Transformation in a Distinctive Institutional Setting: A Study of Regional Development Banks in Indonesia
Authors: Thuda Audy , Hamsal Mohammad , Warganegara Dezie Leonarda , Heriyati Pantri
Published: November 2024

Limited research exists on business transformation strategy within the Indonesian banking sector, particularly regarding regional development banks, which play a crucial role in regional economic advancement. This study investigates the drivers of successful business transformation in Indonesian RDBs and their impact on organizational performance, examining the moderating role of regional government intervention. Employing structural equation modeling, the study analyzed data from 255 branch managers across 27 RDBs. Results reveal that talent development, transformational leadership, and digital adoption significantly drive successful business transformation, which in turn enhances organizational performance. Contrary to expectations, regional government intervention did not demonstrate a moderating effect. This study provides valuable insights for RDB managers and policymakers, emphasizing the imporace of talent development, leadership, and digital adoption as key pillars of successful transformation and highlighting the need for a nuanced understanding of institutional influences within this sector.
Evaluation of Air Traffic Network Resilience: A UK Case Study
Authors: Zhao Tianyu , Escribano-Macias Jose , Zhang Mingwei , Fu Shenghao , Feng Yuxiang , Elhajj Mireille , Majumdar Arnab , Angeloudis Panagiotis , Ochieng Washington
Published: November 2024

With growing air travel demand, weather disruptions cost millions in flight delays and cancellations. Current resilience analysis research has been focused on airports and airlines, rather than the en-route waypoints, and has failed to consider the impact of disruption scenarios. This paper analyses the resilience of the United Kingdom (UK) air traffic network to weather events that disrupt the network’s high-traffic areas. A Demand and Capacity Balancing (DCB) model is used to simulate adverse weather and re-optimise the cancellation, delay, and rerouting of flights. The model’s feasibility and effectiveness were evaluated under 20 concentrated and randomly occurring extreme disruption scenarios, lasting 2 h and 4 h. The results show that the network is vulnerable to extended weather events that target the network’s most central waypoints. However, the network demonstrates resilience to weather disruptions lasting up to two hours, maintaining operational status without any flight cancellations. As the scale of disruption increases, the network’s resilience decreases. Notably, there exists a threshold beyond which further escalation in disruption scale does not significantly impair the network’s performance.
Valley Path Planning on 3D Terrains Using NSGA-II Algorithm
Authors: Xue Tao , Zhang Leiming , Cao Yueyao , Zhao Yunmei , Ai Jianliang , Dong Yiqun
Published: November 2024

Valley path planning on 3D terrains holds significant importance in navigating and understanding complex landscapes. This specialized form of path planning focuses on finding optimal routes that adhere to the natural contours of valleys within three-dimensional terrains. The significance of valley path planning lies in its ability to address specific challenges presented by valleys, such as varying depths, steep slopes, and potential obstacles. By following the natural flow of valleys, path planning can enhance the efficiency of navigation and minimize the risk of encountering difficult terrain or hazards. In recent years, an increasing number of researchers have focused on the study of valley path planning on 3D terrains. This study presents a valley path planning method utilizing the NSGA-II (Non-dominated Sorting Genetic Algorithm II) approach. To ensure that the paths generated by the algorithm closely follow the valley lines, the algorithm establishes an optimization function that includes three optimization criteria: mean altitude, flight route length, and mean offset. To test the performance of this algorithm, we conducted experiments based on workspaces based on three datasets full of 3D terrains and compared it with three baseline algorithms. The evaluation indicates that the suggested algorithm successfully designs routes that closely follow the valley contours.
Planning and Evaluation of Water-Dropping Strategy for Fixed-Wing Fire Extinguisher Based on Multi-Resolution Modeling
Authors: Wang Xiyu , Xue Yuanbo , Tian Yongliang , Liu Hu , Cai Zhiyong
Published: November 2024

The deployment of fixed-wing aircraft in fire-extinguishing operations represents a significant advancement in the domain of aviation emergency rescue. Addressing the challenge of enhancing firefighting efficacy, this study delves into the water-dropping strategies of fixed-wing extinguishers and provides a methodological framework for the strategic planning and assessment of water-dropping tactics, employing multi-resolution modeling. The formulation of the planning algorithm and the structure of the effectiveness evaluation index system are explained accordingly. The corresponding prototype system was designed, comprising four subsystems that utilized distinct resolution models: fire environment simulation, water-dropping point scheme planning, approaching path planning, and mission evaluation simulation. Case studies validate the system’s capability to forecast fire and smoke propagation, plan a water-dropping trajectory based on the fire line, optimize flight paths based on the trajectory, and simulate as well as evaluate the whole firefighting mission process. The above research comprehensively constructs the model, finishes the iterative optimization, and evaluates the water-dropping strategy by simulation. The technical path and methodological framework of studying water-dropping strategies are established. The outcomes of this study provide invaluable support for the parameter inversion design of the fixed-wing extinguisher, offering decision-making assistance to commanders and supplying training scenarios for new aviation crews.
Three-Dimensional Flutter Numerical Simulation of Wings in Heavy Gas and Transonic Flutter Similarity Law Correction Method
Authors: Hu Zhe , Lu Bo , Liu Yongping , Yu Li , Kou Xiping , Zha Jun
Published: November 2024

Wind tunnel testing is a crucial method for studying aircraft flutter. Using heavy gas as the wind tunnel medium can mitigate the escalating issue of test models being overweight as advanced aircraft develop. This paper employs an analytical method for numerical calculations of three-dimensional (3D) wing flutter based on fluid–structure interaction (FSI). Flutter calculations for the Goland wing are conducted, and the results in the air medium are consistent with the literature. In contrast, significant differences in flutter behavior are observed in the heavy gas R134a medium. Compared to air, when the model reaches a critical state in R134a, the incoming flow velocity is lower, the incoming flow density is approximately 3 to 5 times air, and the incoming flow dynamic pressure is about 1.1 to 1.2 times that of air. The correction of heavy gas flutter data is crucial for wind tunnel testing. This paper proposes a correction method based on the unsteady transonic flow similarity law proposed by Bendiksen under quasi-steady conditions. Attempts are made to revise relevant published wind tunnel tests and heavy gas flutter calculation results. The transonic flutter similarity law effectively explains the flutter similarity of rigid models in both heavy gas and air media. Still, it fails in cases with highly reduced frequencies and low mass ratios, such as those encountered with flexible wings.
A Convolution Auto-Encoders Network for Aero-Engine Hot Jet FT-IR Spectrum Feature Extraction and Classification
Authors: Du Shuhan , Han Wei , Kang Zhenping , Liao Yurong , Li Zhaoming
Published: November 2024

Aiming at classification and recognition of aero-engines, two telemetry Fourier transform infrared (FT-IR) spectrometers are utilized to measure the infrared spectrum of the areo-engine hot jet, meanwhile a spectrum dataset of six types of areo-engines is established. In this paper, a convolutional autoencoder (CAE) is designed for spectral feature extraction and classification, which is composed of coding network, decoding network, and classification network. The encoder network consists of convolutional layers and maximum pooling layers, the decoder network consists of up-sampling layers and deconvolution layers, and the classification network consists of a flattened layer and a dense layer. In the experiment, data for the spectral dataset were randomly sampled at a ratio of 8:1:1 to produce the training set, validation set, and prediction set, and the performance measures were accuracy, precision, recall, confusion matrix, F1 score, ROC curve, and AUC value. The experimental result of CAE reached 96% accuracy and the prediction running time was 1.57 s. Compared with the classical PCA feature extraction and SVM, XGBoost, AdaBoost, and Random Forest classifier algorithms, as well as AE, CSAE, and CVAE deep learning classification methods, the CAE network can achieve higher accuracy and efficiency and can complete the spectral classification task.
Effects of Biochar on the Growth and Physiological and Mechanical Properties of Cucumber Plug Seedlings Before and After Transplanting
Authors: Ma Guoxin , Shi Qiang , Wu Yuanchao , Liu Yang , Han Lvhua , Hu Jianping , Mao Hanping , Zuo Zhiyu
Published: November 2024

Since the characteristics of plug seedlings affect the effectiveness of automatic transplanting, this study aimed to explore the effect of the addition of biochar into substrates on the growth of plug seedlings before and after transplanting. The physicochemical properties of substrates with 0%, 5%, 10%, 15%, 20%, and 25% biochar addition all met the requirements of seedling cultivation. The growth trend, root systems, and mechanical properties of seedlings before transplanting and the leaf gas exchange parameters of seedlings after transplanting were measured in this study. The results indicated that the seedlings cultivated with 10% biochar added to the substrate achieved the best growth trend and physiological indices, and the root systems under this treatment were also stronger than those of other treatments, while the seedlings cultivated with 25% biochar treatment were the worst, with less than 22.23% of the growth seen in the 10% biochar treatment, and even less than 1.5% of the growth of the seedlings cultivated without biochar treatment. Since the strong root systems could enhance the mechanical properties of seedling pots, the seedling pots cultivated with 10% biochar added into the substrate possessed the best compression resistance properties, with the maximum value of 49.52 N, and could maintain maximum completeness after free-fall impacting, wherein the loss of root and substrate was only 8.22%. The analysis results of seedlings cultivated after impacting proposed that the seedlings with better growth trends and root systems before transplanting could obtain better leaf gas exchange parameters during the flower stage after transplanting, so the seedlings cultivated with 5%~10% biochar added into the substrate grew better after impacting and then transplanting. It was noticed that the seedlings cultivated with appropriate biochar added into the substrate were able to achieve the optimal growth parameters and mechanical properties before and after transplanting, which were better able to meet the requirements of automatic transplanting. Thus, this study can promote the development of automatic transplanting technology to some extent.
Association of Lameness Prevalence and Severity in Early-Lactation Cows with Milk Traits, Metabolic Profile, and Dry Period
Authors: Jukna Vigilijus , Meškinytė Edita , Urbonavičius Gediminas , Bilskis Ronaldas , Antanaitis Ramūnas , Kajokienė Lina , Juozaitienė Vida
Published: November 2024

This study investigated the prevalence and severity of lameness in dairy cow herds, focusing on its relationship with milk traits, metabolic profile, and dry period management. Lameness was evaluated in 4221 multiparous Holstein dairy cows during early lactation (up to 60 days postpartum) using a 1-to-5 scale. The average lameness score was 1.67, with a prevalence of 10.66% (scores 3 to 5) and 4.55% classified as severe (scores 4 to 5). Severe lameness was associated with energy-corrected milk losses of −11.00 kg/day (p < 0.001) and a decrease in milk lactose concentration by −0.16 percentage points (p < 0.001), alongside a rise in somatic cell scores by +0.11. The incidence of cows with a milk fat-to-protein ratio below 1.2 increased by 21.7 percentage points, while those with a ratio above 1.4 rose by 19.1 percentage points as lameness worsened. Additionally, non-esterified fatty acid concentrations increased by 1.46 times as lameness severity intensified (p < 0.001). Cows without lameness had blood cortisol levels 1.86 times lower than affected cows, with cortisol tripling in those with the highest scores. A dry period of 30 to 60 days was correlated with more healthy cows, whereas periods over 90 days resulted in 1.586 times higher odds of lameness (p < 0.05). This research underscores the need for improved management strategies to enhance dairy cow welfare and productivity.
Multi-Dimensional Assessment, Regional Differences, and Influencing Factors of Agricultural Water Pollution from the Perspective of Grey Water Footprint in Zhejiang Province, China
Authors: Zhu Hua , Zhang Qing , You Hailin , Liu Ying
Published: November 2024

The implementation of differentiated governance for agricultural water pollution (AWP) plays a significant role in alleviating the pressure on agricultural water resources. However, research that comprehensively assesses AWP and its influencing factors from a multidimensional perspective remains relatively limited. This study utilized the grey water footprint (GWF) model to quantify the agricultural grey water footprint (AGWF), agricultural grey water footprint efficiency (AGWFE), agricultural grey water footprint intensity (AGWFI), and agricultural water pollution level (AWPL) in Zhejiang from 2010 to 2020. Subsequently, we applied the standard deviational ellipse (SDE), the kernel density estimation (KDE), and the Dagum Gini coefficient to delve into the dynamic evolution and regional disparities of these indicators. Ultimately, we leveraged both the random forest model and the panel regression model to identify and examine the key factors shaping AGWF-related indicators. The results show that: (1) From 2010 to 2020, in Zhejiang, both AGWF and AGWFI exhibit a trend of first increasing and then decreasing, peaking in 2012. In contrast, AGWFE has consistently increased over the years, reaching an increase of 54.56 CNY/m3 by 2020. Meanwhile, despite fluctuations, AWPL in Zhejiang shows an overall gradual decline. (2) The centroids of relevant indicators for AWP in Zhejiang are primarily located in Jinhua (for AGWF and AGWFI), Shaoxing (for AWPL), and in the area where AGWFE converge. (3) Compared to 2010, the regional disparities in AGWF and AWPL have shrunk significantly in 2020, whereas the regional differences in AGWFE and AGWFI have increased to some extent. In most years, the regional disparities in AGWF, AGWFI, and AWPL are more pronounced in Northeastern Zhejiang compared to the southwestern part. (4) The influencing factors of AGWF, AGWFE, and AGWFI exhibit significant regional heterogeneity. In Northeastern Zhejiang, the primary factors influencing them are technological innovation, resource endowment, and crop-cultivation methods. Conversely, in the southwestern region, the primary factors exerting the same influence are the application intensities of fertilizers, pesticides, and agricultural film application. The primary drivers of AWPL in Zhejiang are grain yield, water resource availability, and crop-planting structure. Notably, these factors do not exhibit regional heterogeneity. The paper proposes AWP control policies from both a comprehensive and multi-dimensional perspective.