bluuebunny/crossref_metadata_2025 huggingface dataset:
Purple urine bag syndrome: When the urine turns purple – An under diagnosed spot diagnosis
Authors:   Clinic for Pneumology, Heckeshorn Lung Clinic, Helios Clinic Emil von Behring, Berlin, Kodde Cathrin , Othmer Till ,   Clinic for Pneumology, Heckeshorn Lung Clinic, Helios Clinic Emil von Behring, Berlin, Krieger David ,   Clinic for Pneumology, Heckeshorn Lung Clinic, Helios Clinic Emil von Behring, Berlin, Polsfuss Silke ,   Institute for Microbiology, Immunology and Laboratory Medicine, MVZ at the Helios Clinic Emil von Behring, Berlin, Bauer Torsten ,   Clinic for Pneumology, Heckeshorn Lung Clinic, Helios Clinic Emil von Behring, Berlin
Published: October 2021

The Purple Urine Bag Syndrome (PUBS) is a rare condition in which the urine turns purple. It may occur in Urinary Tract Infections (UTIs) when bacteria metabolize dietary tryptophan to indole resulting in indigo (blue) and indirubin (red). This condition is mostly seen in elderly female patients with permanent urinary bladder catheterization. Patients, relatives and health professionals may be concerned about this discolouration, which is usually harmless. Medical management of PUBS involves frequent urinary bag change, antibiotic therapy and most importantly reassurance. We report an 89-years-old long-term catheterized female nursing home resident who was admitted to the emergency room because of a Community Acquired Pneumonia (CAP). After a few days of inpatient treatment her urine bag turned purple. Antibiotic therapy continued and the indwelling urinary catheter was changed resulting in clear urine. Keywords: Purple urine bag syndrome (PUBS); purple discolouration; urinary tract infection (UTI); long-term catheterization.
Breast MRI in the setting of breast carcinoma with suspected microcalcifications and his predictive value in breast cancer management: An interesting case report
Authors:   Unit of General Surgery, Great Metropolitan Hospital, Reggio Calabria, Italy, Fava Maria Giovanna , Turano Lorena ,   Unit of Radiology, Great Metropolitan Hospital, Reggio Calabria, Italy, Messina Francesco ,   Unit of Radiology, Great Metropolitan Hospital, Reggio Calabria, Italy, Plutino Maria Francesca ,   Unit of Pathological Anatomy, Great Metropolitan Hospital, Reggio Calabria, Italy, Tebala Carmela ,   Unit of Radiology, Great Metropolitan Hospital, Reggio Calabria, Italy, Azzarello Domenico ,   Unit of Oncology, Great Metropolitan Hospital, Reggio Calabria, Italy, Calabrese Grazia ,   Unit of Radiology, Great Metropolitan Hospital, Reggio Calabria, Italy., Arcadi Nicola ,   Unit of Radiology, Great Metropolitan Hospital, Reggio Calabria, Italy.
Published: October 2021

The Breast Imaging Reporting and Data System (BI-RADS®) is a standardized system of reporting breast pathology used also for Magnetic Resonance Imaging (MRI). It facilitates clear communication between the radiologist and other physicians as surgeons involved in senology, by providing a lexicon that compares breast gland structures to assessment categories in the management recommendations for the onco-surgical choices. In 30% of all clinical cases in women, breast cancer is correlated to micro-calcifications [1] or occulted lesion as non-palpable nodule and this diagnostic management is not easy, especially if you haven’t an easy access to all the equipment of interventional methods as stereotactic biopsy or radio-pharmacological detection’s method (for example R.O.L.L., Radioguided Occult Breast Lesion Location), and if you cannot know the real distribution of suspected or malignant microcalcifications in mammography. MRI is more accurate than mammography for prediction of residual malignancy after excisional biopsy for breast cancer with suspicious micro-calcifications [2,3]. MRI’s report often influences the surgical performance. MRI can be useful to correlate malignant microcalcifications with pathological tumor size and to allow the pre-operative drawing in onco-plastic surgery for breast cancer. MRI might be more reliable for predicting residual tumor size after an onco-plastic surgical procedure or a conservative mastectomy, with significant influence on surgical outcomes and disease free survival and risk of relapse [4,5]. Keywords: Breast cancer; Breast MRI; Microcalcifications; Multidisciplinary consultation; Breast conservative surgery.
Closed posterior dislocation of ankle joint without fracture: A case report and literature review
Authors:   DNB Orthopaedics, Trust Registrar, Trauma and Orthopaedics, Pennine Acute Hospital NHS Trust, UK, Nugur Ashwani , Hoggett Lee ,   Speciality Registrar, Trauma and Orthopaedics, Health Education North West, UK., Lokanathan Siddharth ,   DNB Orthopaedics, MRCS, Speciality Doctor, Trauma and Orthopaedics, Pennine Acute Hospital NHS Trust, UK, Akhtar Sabeen ,   FRCS (Trauma and Orthopaedics), Consultant Foot and Ankle Specialist, Pennine Acute Hospital NHS Trust, UK.
Published: October 2021

Pure Ankle dislocation is an ankle dislocation without any associated fractures of the ankle and an intact tibiofibular syndesmosis. Only a few isolated case reports and small series of cases are reported in literature. We report a posterior dislocation of ankle joint without any bony fractures with description of its mechanism, management, and literature review Keywords: Pure Ankle dislocation; ankle dislocation without fracture; posterior dislocation of ankle.
Madelung’s disease: A case report of laryngeal localization and a review of the literature
Authors:   Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy., Elli Fabrizia , Stacchini Marco ,   Division of Otorhinolaryngology, M. Bufalini Hospital, Cesena, Italy, Arosio Alberto Daniele ,   Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy., Priola Roberta ,   Division of Otorhinolaryngology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy, Mazzocco Tommaso ,   Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Italy., Limarzi Marco ,   Division of Otorhinolaryngology, M. Bufalini Hospital, Cesena, Italy
Published: October 2021

Madelung’s Disease (MD), also known as benign multiple symmetric lipomatosis or Launois-Bensaude syndrome, is a rare condition. The characteristic feature is the presence of numerous diffuse lipomas at the level of the neck or upper limbs. The etiology is unknown, but a close association with ethyl abuse has been observed. The use of radiological examinations such as ultrasound, computed tomography and magnetic resonance imaging is helpful for the differential diagnosis. There are two classifications mainly used: The Enzi classification and the Donhauser classification. In this article we present a case of MD with laryngeal localization. A 50-year-old man was referred to our department complaining of dysphonia for about 6 months. An abnormal and diffuse enlargement of the anterior part of the neck was noticed, compatible with “Madelung’s Collar”. Fiberoptic examination of the larynx revealed the presence of a lipomatous-like neoformation of the left false vocal cord. The patient underwent surgical removal of the laryngeal neoformation with transoral laser microsurgery. With this article we suggest a possible diagnostic and therapeutic procedure for the treatment of laryngeal lipomatosis. Keywords: Lipoma; TML; Larynx; Dysphonia; ENT
High risk of delayed or missed diagnosis of mucinous appendiceal neoplasm by transvaginal ultrasound: A case series
Authors:   Assisted Reproductive Technology Centre, Careggi University Hospital, Florence, Italy., Rizzello Francesca , Vannucci Giulia ,   University of Florence, Florence, Italy, Coccia Maria Elisabetta ,   Department of Biomedical, Experimental and Clinical Sciences “Mario Serio”, University of Florence, Florence, Italy
Published: October 2021

Appendiceal Neoplasm is a rare tumour with a vague and nonspecific clinical presentation. Delayed or missed diagnosis could result in mucin spill into the peritoneal cavity because of cancer infiltration or spontaneous rupture of appendix. This condition is called Psuedomyxoma Peritonei (PMP) and has a very poor prognosis if not treated properly. We present 4 cases of Appendiceal Neoplasm misdiagnosed as adnexal masses of different origin: Dermoid cyst of the right ovary; stump of the previously removed tube; ectopic pregnancy; ovarian malignancy. It is important for gynaecologists to recognize mucinous appendiceal neoplasm in the differential diagnosis of right adnexal masses in order to reduce the risk of misdiagnosis. Keywords: Appendiceal Neoplasm, Adnexal Masses, Transvaginal Ultrasound, Misdiagnosis.
An unusual case of delayed and recurrent bleeding after renal biopsy in a patient with malignant hypertension
Authors:   Division of Nephrology, National University Health System, Singapore., Teng Jeremy JW , Wong Emmett TY ,   Division of Nephrology, National University Health System, Singapore., Leo Christopher CH ,   Division of Nephrology, National University Health System, Singapore., Lau Titus WL ,   Division of Nephrology, National University Health System, Singapore., Tok Pei Loo ,   Division of Nephrology, National University Health System, Singapore.
Published: October 2021

We report a 35-year-old Asian man who presented with symptomatic malignant hypertension with complications of acute kidney injury, thrombocytopenia and microangiopathic haemolytic anemia. A renal biopsy done led to recurrent bleeding needing repeated embolization. We highlight the importance of continued monitoring for post biopsy bleeding even weeks after the biopsy for high-risk cases and discuss the aspects of prevention of severe post biopsy bleeding. Keywords: Renal biopsy; Malignant hypertension; Embolization; Desmopressin.
Can I have epidural analgesia if I have tinea versicolor?
Authors:   Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8 00168, Rome, Italy., Ciano Francesca , Biancone Matteo ,   Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8 00168, Rome, Italy., Zanfini Bruno Antonio ,   Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8 00168, Rome, Italy., Catarci Stefano ,   Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8 00168, Rome, Italy., Draisci Gaetano ,   Department of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli 8 00168, Rome, Italy.
Published: October 2021

Labor and delivery, while perceived as gratifying and joyful, are nonetheless among the most painful events women can experience in life. Treating pain is nowadays one of the essential elements in assisting women during labor. Epidural analgesia is the best option to ensure the optimal control of pain for the mother without compromising the wellbeing of the fetus. The main contraindications to neuraxial analgesia techniques include patient refusal, known bleeding diathesis or abnormal coagulation tests, elevated intracranial pressure (particularly in the presence of an intracranial space occupying lesion), severe aortic or mitralic valve stenosis and infections at the puncture site [1]. There are many pathogens responsible for cutaneous infections at the dorsal-lumbar level, yeasts of the Malassetia genus being the most commonly implicated. Malassetia Globulosa is the predominant species in the Tinea Versicolor infection [2,3]. Also implicated are M. Sympodialis, M. Furfur and others as well [4]. These fungi are normal components of the cutaneous flora but the transformation from yeasts to micelia can lead to the pathology. The cause for this occurrence is still unknown, yet there are a few contributing factors leading to this infection that affects mostly adolescents and young adults; these are genetic predisposition [5], heat and humidity, immunosuppression, contraceptives, pregnancy and malnutrition. It manifests with characteristic hypo- or hyper-pigmented spots alongside the trunk, the neck, and the face. The majority of the times infection is entirely superficial but cases of meningitis and Central Nervous System (CNS) infections from hematogenous spread have been reported [6,7]. The literature supports with data that adequate antiseptic preparation of the skin effectively prevents meningitis occurrence after epidural puncture [8]; other cases are reported where a small incision of the skin allows for a safer passage of the needle directly in the subcutis without going thnrough the corneal layer.
Nosographic considerations on obsessive-compulsive disorder occurring exclusively during the menstrual phase
Authors:   Laboratory of Health Sciences Research, Agadir Medical School, Ibn Zohr University, Agadir, Morocco, Laaraj Hicham , Ouhamou Mina ,   Laboratory of Health Sciences Research, Agadir Medical School, Ibn Zohr University, Agadir, Morocco, Omari Omar El ,   Laboratory of Health Sciences Research, Agadir Medical School, Ibn Zohr University, Agadir, Morocco, Doufik Jalal ,   Laboratory of Health Sciences Research, Agadir Medical School, Ibn Zohr University, Agadir, Morocco, Mouhadi Khalid ,   Laboratory of Health Sciences Research, Agadir Medical School, Ibn Zohr University, Agadir, Morocco
Published: October 2021

The relationship between the menstrual cycle and mood disturbances has been described in the literature and is linked to changes in the secretion of sex hormones. Rare studies have reported the exacerbation of obsessions during menstruation, while no case reports the onset of premenstrual Obsessive-Compulsive Disorder (OCD). Nosographically, obsessive symptoms are not part of premenstrual syndrome, and no specification of the menstrual cycle for obsessive disorders was mentioned in DSM 5 (Diagnostic and Statistical Manual of Mental Disorders). We report a 39-year-old patient followed for panic disorder since adolescence, and who currently presents for obsessive symptoms that meet the diagnostic criteria for an obsessive-compulsive disorder, and which have the particularity of occurring exclusively during menstruation. Our case emphasizes the importance of establishing a new nosographic framework that takes into account the development of obsessive-compulsive symptoms related to the menstrual cycle. Keywords: Obsessive-compulsive disorder; menstruation cycle; nosography.
Tuberculosis of bilateral ankles: Misdiagnosed as rheumatoid arthritis
Authors:   Department of Rheumatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan 030032, Shanxi, China., Wang Haiyao , He Ping ,   Department of Nephrology, Changzhi People’s Hospital, Changzhi 046000, Shanxi, China., Zhang Gailian ,   Department of Rheumatology, Shanxi Provincial People’s Hospital, Taiyuan 030012, Shanxi, China., Gao Jinfang ,   Department of Rheumatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan 030032, Shanxi, China., Zhang Liyun ,   Department of Rheumatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Affiliated to Shanxi Medical University, Taiyuan 030032, Shanxi, China.
Published: October 2021

The osteoarticular tuberculosis is a uncommon diease, which is accout for 0.1%-0.3% of Tuberculosis (TB). The involoment of foot and ankle is only 0.01%-0.03% of TB, particularly the bilateral feet and ankles are affected is extremely rare. Futhermore, its clinical manifestation is atypical and similar with autoimmune disorder, subacute or chronic pyogenic arthritis, osteochondrosis, benign bone tumors and so on, which conduce to the delay of its diagnose and therapy along with unfavourable prognosis. Here we present a case of a 52-year-old man with bilateral feet and ankles tuberculous arthritis, misdiagnosed successively Rheumatoid Arthritis (RA) and Poncet’s diease. It is hope that can enhance the alertness about osteoarticular tuberculosis. Keywords: Osteoarticular tuberculosis; ankle; foot; misdignose.
Cysticercotic fourth ventricle ependymitis
Authors:   School of Medicine of Universidad Nacional Mayor de San Marcos, Peru, Cosentino Carlos , Vélez Miriam ,   Department of Neurodegenerative Disorders, Instituto Nacional de Ciencias Neurológicas, Peru., Torres Luis ,   Department of Neurodegenerative Disorders, Instituto Nacional de Ciencias Neurológicas, Peru.
Published: October 2021

Neurocysticercosis is endemic in many regions of the world. Extra parenchymal forms of neurocysticercosis are infrequent but may be associated with hydrocephalus. We report the case and show a typical MRI of fourth ventricle ependymitis caused by cysticercosis. Keywords: Ependymitis; cysticercosis.
Duplex optogenetic stimulation system modulates compulsive behaviors bidirectionally
Authors:   Emotional Brain Institute, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA., Menezes Edenia , Ashurov David ,   Emotional Brain Institute, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA., Cunha Catarina Sousa ,   Emotional Brain Institute, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Published: October 2021

Decisions enable us to consider our actions while adjusting behaviors to a relentlessly changing environment. Since conscious decision making requires our full attention and is therefore expensive, we use a cheaper system for everyday and repetitive tasks that run automatically without conscious evaluations, commonly described as habits. The combination of these two systems is highly adaptive. However, if there is a disruption in these systems’ balance, mental illnesses such as Obsessive-Compulsive Disorders (OCD) or addiction may arise. Now, how does a newly acquired memory or behavior transition to a habit? We know that the striatum’s dorsolateral region (DLS) plays a significant role in sustaining successful behaviors and habits manifestation. Furthermore, it has been shown that the micro-circuitry of the DLS is organized into two functional opposing pathways that consist of the direct pathway striatal spiny projection neurons (dSPNs), which facilitate movement, and the indirect pathway SPNs, which inhibit actions. Already Freud wrote in the letters to his friend Fliess that memory and motive are inseparable, and its recollection would have no force or meaning unless it would be coupled to a motive or emotion. Therefore, we hypothesize that emotional-associated cues would directly prime the DLS through the amygdala to turn newly acquired behaviors into habits. We are adding new supporting insight for this hypothesis by using a duplex optogenetic stimulation system of the amygdala input in the DLS, modulating specific compulsive behaviors bidirectionally. These behavior modulations were accompanied by spine density modulations and intrinsic excitability changes in the SPNs of the DLS. Keywords: Compulsions; Habits; Optogenetics; Neuromodulation; Dorsolateral striatum; Amygdala.
Understanding attendees’ transformative experiences following Tony Robbins’s Unleash the Power Within seminars
Authors: Bradley Sue
Published: October 2021

Tony Robbins is an American life coach and entrepreneur who claims his motivational workshop, Unleash the Power Within (UPW) can transform people’s lives. This article is based on an interpretative phenomenological analysis of eight participants who had attended different UPW seminars and explored their experiences of transformation. Eight themes were identified: (1) a change in their sense of self, (2) the development of new skills, (3) changes in lifestyle, (4) transformation/conversion, (5) changes in relationships, (6) permanency of change, (7) feelings of fear versus anticipation and (8) loss versus gain. The research concluded that participants had undergone transformation involving significant, valued and enduring changes centred on new meaning in their lives. Further research was suggested to examine both a wider and more in-depth approach, as personal development workshops offer a large and potentially rich field of transpersonal study focused on human meaning-making and change.
Kesalahan Jawaban Siswa SMA berdasarkan Newman Ditinjau dari Tingkat Kecemasan Matematis
Authors: Suhaeti Ati , Aminah Neneng , Wahyuni Ika
Published: October 2021

Penelitian ini bertujuan untuk mengetahui jenis kesalahan yang dilakukan siswa SMA berdasarkan NEA ditinjau dari tingkat kecemasan matematis siswa. Metode penelitian yang digunakan adalah kualitatif dengan jenis penelitian study kasus (case study). Subjek penelitian ini yaitu kelas XI MIPA 1 SMAN 1 Luragung sebanyak 5 siswa yang dipilih berdasarkan pertimbangan tertentu (purposive sampling). Teknik pengumpulan data yang digunakan yaitu angket kecemasan matematis, soal tes, dan wawancara. Hasil menunjukkan bahwa siswa dengan tidak ada kecemasan matematis melakukan kesalahan memahami (comprehension error), dan kesalahan menuliskan jawaban akhir (encoding). Siswa dengan kecemasan matematis ringan melakukan kesalahan memahami (comprehension), dan kesalahan menuliskan jawaban akhir (encoding). Siswa dengan kecemasan matematis sedang melakukan kesalahan membaca (reading error), kesalahan transformasi (transformation error), kesalahan ketrampilan proses (process skill error), dan kesalahan menuliskan jawaban akhir (encoding). Siswa dengan kecemasan matematis berat melakukan kesalahan memahami (comprehension), kesalahan proses (process skill error), dan kesalahan menuliskan jawaban akhir (encoding). Siswa dengan kecemasan matematis berat sekali melakukan kesalahan membaca (reading error), kesalahan memahami (comprehension), kesalahan transformasi (transformation error), kesalahan ketrampilan proses (process skill error), dan kesalahan menuliskan jawaban akhir (encoding).
Die Wahrnehmung der eigenen Professionalität von Chemielehrenden zu unterschiedlichen Zeitpunkten ihrer Berufslaufbahn
Authors: Lengauer Alexander
Published: October 2021

In diesem Beitrag werden nach einer kurzen Einführung in das EPIK-Modell und das Laufbahnmodell von Huberman die Ergebnisse einer Studie präsentiert, die untersucht, ob sich das subjektiv wahrgenommene Professionsempfinden von Chemielehrenden der Sekundarstufe im Laufe der Berufsausübung verändert. Dabei wurde primär untersucht, inwieweit die Faktoren Dienstalter, Ausbildungsvariante, Fortbildungstätigkeit oder Geschlecht einen Einfluss auf die selbst wahrgenommenen Kompetenzen haben. Als quantitative Studie konzipiert erfolgte eine Befragung der Mitglieder des Verbands der Chemielehrer/innen Österreichs (VCÖ) per Online-Fragebogen mit rund 50 Items, wobei von knapp 200 Teilnehmerinnen und Teilnehmern Fragen zur gefühlten Professionalität beantwortet wurden. Im Zuge der deskriptiven sowie inferenzstatistischen Auswertung (einfaktorielle MANOVA sowie t-Test nach Pearson) konnte gezeigt werden, dass sowohl das Dienstalter als auch die Fortbildungstätigkeit einen statistisch signifikanten Einfluss auf die selbstwahrgenommene Professionalität in einigen Bereichen haben, wohingegen die absolvierte Ausbildung und das Geschlecht von geringer Bedeutung sind. Die Ergebnisse legen den Schluss nahe, dass eine Lehrperson zu keinem Zeitpunkt der Berufslaufbahn tatsächlich „fertig“ ist, sondern die Wahrnehmung als professionell arbeitende Pädagogin bzw. professionell arbeitender Pädagoge ständigen Veränderungen unterworfen ist.
Nachdenken über Unendlichkeit
Authors: Maaß Jürgen
Published: October 2021

Mit diesem Text möchte ich dazu motivieren, sich in der Schule und außerhalb mit dem Thema „Unendlichkeit“ zu beschäftigen. Dazu wähle ich Zugänge über Mathematik, Philosophie und Religion, die je nach Interesse und Möglichkeiten genutzt werden können. Diese Thematik hat in der Geschichte viele Menschen beschäftigt; sehr viele bedeutende Werke dazu finden sich in den Bibliotheken. Dennoch soll die Ehrfurcht davor oder die Tatsache, dass immer Fragen offenbleiben werden, niemanden davon abhalten, sich überhaupt mit der Thematik zu beschäftigen. Im Gegenteil: Vieles lässt sich schon mit jüngeren Schülerinnen und Schüler so diskutieren, dass Wissenszuwachs und Neugier auf mehr erreicht werden können. In den Text eingewoben sind konkrete Unterrichtsvorschläge.
Zur inhaltlichen Schwerpunktsetzung im Rahmen der verbindlichen Übung „Digitale Grundbildung“ an österreichischen Mittelschulen
Authors: Oppl Stefan , Fuchs Wolfgang , Dobiasch Martin
Published: October 2021

Seit dem Schuljahr 2018/19 wird in Österreich die verbindliche Übung "Digitale Grundbildung" flächendeckend in der Sekundarstufe I umgesetzt. Der Lehrplan ist durch eine sehr umfassend und detaillierte ausgearbeitete Charakterisierung der zu adressierenden Themenfelder gekennzeichnet, in der die inhaltliche Heterogenität des Feldes sichtbar wird. In der Umsetzung herrscht weitgehende Flexibilität hinsichtlich des Ausmaßes, der Art der Verankerung und der inhaltlichen Schwerpunktsetzung. Vor diesem Hintergrund widmet sich die vorliegende Studie der Frage nach der konkreten Umsetzung der verbindlichen Übung in der Schulpraxis. Dazu wurden im Schuljahr 2019/20 Lehrpersonen und Schulleitungen aller Vorarlberger Mittelschulen befragt. Betrachtet wurde neben den Rahmenbedingungen der Umsetzung, den konkreten Umsetzungsformen und den Weiterbildungs-bedarfen auch die Wichtigkeitswahrnehmungen der im Lehrplan definierten acht Teilbereiche und deren Priorisierung in der Unterrichtspraxis. Die Ergebnisse zeigen insgesamt eine breit über Fächergrenzen hinweg getragene und ambitionierte Umsetzung der verbindlichen Übung in der Praxis. Inhaltlich zeigt sich ein heterogenes Bild, in dem jene Teilbereiche, die eine informatisch-technische Perspektive abbilden, tendenziell von einem Großteil der Lehrpersonen und Schulleitungen als weniger wichtig wahrgenommen und in der Umsetzung eher nachrangig behandelt werden. Der Artikel versucht abschließend, mögliche Gründe für dieses Ungleichgewicht zu identifizieren, die in weiterführenden Studien umfassender zu untersuchen wären.
Entwicklungspotenzial im Kunstunterricht sowie in der Lehrerausbildung
Authors: Szettele Katinka , Balzarek Heidelinde
Published: October 2021

In der vorliegenden Studie wird auf das Thema Förderung des kreativen Potenzials im schulischen Kontext eingegangen. Es wird über den Einsatz kreativitätsfördernder Methoden sowie Einstellungen von Lehrpersonen gegenüber Kreativität anhand jüngster Forschungsergebnisse diskutiert. Im weiteren Teil der Studie wird auf den Kreativitätsbegriff des Lehrplans bzw. im fachdidaktischen Diskurs reflektiert und die Relation von Kunst und Kreativität als eine Resonanzbeziehung dargestellt. Das Entwicklungspotenzial im Kunstunterricht wird am Beispiel einer Online-Werkstattarbeit präsentiert, die in einer partnerschaftlichen Kooperation zweier Ausbildungsinstitutionen (Pädagogische Hochschule Niederösterreich und Eötvös-József-Hochschule Baja, Ungarn) im Studienjahr 2020/2021 verwirklicht wurde. Zum Abschluss werden sowohl die pädagogisch-praktischen Ansätze zur Kreativitätsförderung von Hochschulstudierenden in Ungarn als auch Ergebnisse der mit dem Instrument TSD-Z durchgeführten Untersuchung vorgelegt.
Lesson Study in Vocational Education and Training
Authors: Mewald Claudia
Published: October 2021

This paper introduces the ERASMUS+ project LS4VET, which aims to develop a Lesson Study model for the VET sector with the goal to encourage innovation and change in vocational education by creating an open-online course to support collaborative professionalism for VET educators. The status quo of Lesson Study in the four partner countries Austria, Hungary, Malta, and the Netherlands is described and an outlook on the development of a Lesson Study model for VET is given.
Phenolic compounds as antiviral agents: An In-Silico investigation against essential proteins of SARS-CoV-2
Authors: Majdi Hammami , Zar Kalai Feten , Yeddess Walid , Saidani Moufida
Published: October 2021

Plant biodiversity is endowed with a huge composition and variability of active molecules known for their therapeutic effects against several diseases. In this current work, several phenolic compounds are subject of in silico evaluation of their interactions with six severe acute respiratory syndrome coronavirus (SARS-CoV) enzymes to evaluate the binding mode and mechanism of phenolic compounds interactions with SARS-CoV-2 enzymes. Results of molecular docking and data analysis revealed that the importance of interactions was dependent to the phenolic class of tested ligand; tannin, biflavone and flavonoid glycoside were the most interactive classes. Among the top three ranked molecules recording lower binding energy against each virus protein target, In conclusion, it was found that Amentoflavone, Dieckol, Bilobetin, Punicalagin, Tellimagrandin-I, Tannic acid, Sciadopitysin, Ginkgetin and Chebulagic acid could be a promising antiviral drug since they present more important binding energy than conventional ones. Their interactions were justified by the Wenn diagram and Ramachandran plot. However, these phenolic compounds recorded an important bioavailability score and found fulfilling most of the drug-likeness criteria such as Lipinski's rule. Clearly, all observations point to further required works aiming to examine more deeply the possibility of using these molecules that could be probably a subject of pre-clinical studies.
YAYILMACI MİLLİYETÇİ İDEOLOJİ BELİRLENİMLİ TOPLUMSAL FORMASYONLARIN YÜKSELİŞİ: EKONOMİ POLİTİK AÇIKLAMA
Authors: AKDAĞ İnan
Published: October 2021

İdeolojinin kendisine ait bir tarihi yoktur. Tarihi olan ekonomidir. İdeoloji, tarihsel olarak ekonominin aldığı biçime bağlı olarak şekillenmektedir. Bu bağlamda devletler, nötrdür. Tarihsel olarak devletler, milliyetçi, sosyalist, liberal, emperyalist vb. biçimler almaktadır. II. Dünya Savaşı sırasında gördüğümüz yayılmacı milliyetçi ideolojiler de gelip geçicidir. Temel ekonominin tarihsel hareketidir. Kapitalist üretim tarzında sermaye belirli bir süre basit yeniden üretim yaptıktan sonra genişletilmiş yeniden üretime geçmektedir. Genişletilmiş yeniden üretim daha fazla Pazar, daha fazla hammadde, daha fazla ucuz emek gücü istemektedir. Bu zorunluluk, gelişmiş kapitalist ülkelerin emperyalist ülkelere dönüşmesine yol açmaktadır. Merkezden çevreye doğru yayılmacılık karşımıza çıkmaktadır. Devletler yayılırken politik ve ideolojik yapısını da yeniden organize etmek durumunda kalmaktadır. Yayılmacı milliyetçi ideoloji bu ihtiyacı sağlamaktadır. Devletler, silahlanmakta ve bütçesinin büyük kısmını dış ülkelere doğru yönlendirirken içeride kendi halkını ikna etmek ve mobilize etmek durumundadır. Bu çalışmanın amacı, yayılmacı milliyetçi ideolojinin yükselişini ekonomi politik temellerde analiz etmektedir. Çalışmanın kapsamı, yayılmacı milliyetçiliğin yükselişe geçtiği 1920’li yıllar, olgunlaştığı 1930’lı yıllar ve çöküşe geçtiği 1940’lı yıllardır. Çalışmanın önemi, yayılmacı milliyetçiliğe ekonomi politik bir çerçeve çizmektir. Çalışmanın hipotezi, yayılmacı milliyetçiliğin arka planında, ulusal burjuvazinin genişleyen artı-değer üretimine bağlı olarak, yeni pazar arayışları ve hammadde kaynaklarının yeniden el konulma mücadelesi ve kısaca dünyanın sömürge ülkelerinin yeniden paylaşılması mücadelesi bulunduğunu ileri sürmektir. Yayılmacı milliyetçilik, bu yanıyla, emperyalizmin ideolojik aparatıdır. Dolayısıyla yayılmacı milliyetçilik, taşıyıcı bir olgudur.
Caracteristicas dos óbitos por COVID-19 na Paraíba e no Brasil segundo diferentes fontes de dados
Authors: Ferreira Assel Muratovna , Moura Lucas de Almeida , Paes Neir Antunes
Published: October 2021

Este estudo teve como objetivo analisar a qualidade dos dados de óbitos por COVID-19 no Brasil e no Estado da Paraíba, captados por diferentes portais oficiais do governo brasileiro, ocorridos da 12ª a 35ª semana epidemiológica do ano de 2020. Foi realizada a quantificação dos totais de óbitos por COVID-19 desagregada por faixa etária e sexo, com análise dos eventos de ocorrência de picos da pandemia, do “time lag” e a razão de sexo. No contexto estadual, tomando a SES como referência, a subnotificação de óbitos alcançou no caso do Painel, 7,6%; no SIM, 11,2%; Registro Civil por data de ocorrência de óbito, 20,3% e do Registro Civil por data de registro de óbito, 25,4%.  A fonte que menos registrou óbitos por COVID-19 no país foi a do Portal da Transparência (data do registro). A análise da razão de sexo revelou tanto para o Brasil, quanto para o estado maior mortalidade entre homens, com pico da razão de sexo na faixa etária de 40 a 49 anos. Alerta-se para o fato de que qualquer fonte que se use como base para a construção de indicadores para COVID-19 no Brasil e na Paraíba, está subnotificada e, portanto, podem comprometer severamente todo e qualquer indicador construído sobre a mortalidade.
The Effect of Remuneration and Job Satisfaction on Employee Performance in Public Works and Spatial Planning Agency (PUPR) of Seluma Regency
Authors: Vesno Yen , Soleh Ahmad , Handayani Sri
Published: October 2021

The aim of this study is to determine the effect of remuneration and job satisfaction on employee performance at Public Works and Spatial Planning Agency (PUPR) of Seluma Regency.The sample in this study were all employees at the Public Works and Spatial Planning Agency (PUPR) of Seluma Regency who had become State Civil Servants (ASN) as many as 52 people. The sampling method is by means of a census. The data collectiontechnique by means of a questionnaire. The analytical method used is multiple regression analysis, hypothesis testing t and hypothesis testing f.The regression equation results are Y = 6.045 + 0.419X1 + 0.458 X2 with a positive regression direction, meaning that if there is an increase in remuneration and job satisfaction, the performance will also increase. Remuneration has a significant effect on employee performance at Public Works and Spatial Planning Agency (PUPR) of Seluma Regency. This is evidenced by the results of partial hypothesis testing (t test) that the significant value of 0.000 is smaller than 0.05. This means that if the remuneration increases, the employee performance will also increase. Job satisfaction has a significant effect on employee performance at Public Works and Spatial Planning Agency (PUPR) of Seluma Regency. This is evidenced by the results of partial hypothesis testing (t test) that the significant value of 0.000 is smaller than 0.05. This means that if organizational commitment increases, employee performance will also increase. Remuneration and job satisfaction have a significant effect together on the employees performance at Public Works and Spatial Planning Agency (PUPR) of Seluma Regency. This is evidenced by the results of simultaneous hypothesis testing (f test) that the significant value is 0.000 less than 0.05.
Anemia and Mineral Bone Disorders in Patients with End Stage Renal Disease on Maintenance Hemodialysis
Authors: Anees Muhammad , Ahmad Sajjad , Raja Khalid Mahmood , Mushtaq Mirrah , Ibrahim Muhammad
Published: October 2021

Objective: To observe the pattern of anemia and mineral bone disorders (MBD)in patients with End Stage Renal Disease (ESRD) on maintenance hemodialysis (MHD) at Nephrology Department, Mayo Hospital and Shalamar Hospital, Lahore.

Methodology: Two hundred patients who were undergoing MHD for more than three months were included in the study. Patients with Acute Kidney Injury (AKI) were excluded from the study. Patient’s demographic data, laboratory reports and dialysis record were noted in a predesigned proforma.

Results: Two hundred patients were included in study, 105(52.5%) were male and rest of them were female. Major cause of ESRD was Diabetes Mellitus 83 (41.5%) followed by Hypertension 80 (40%) and Nephrolithiasis 15 (7.5%). Most of the patients belonged to middle age group, poor socioeconomic class, lower level of education and were getting twice-weekly dialysis. Mean hemoglobin was 10.17±1.69 gm/L and most of the patients 137 (68.5%) were anemic with hemoglobin level less than 11gm/dl. Iron was adequate in 170 (85%) patients with transferrin saturation more than 20%. Hypocalcemia (<8.5mg/dl), hypophosphatemia and calcium phosphorus product was less than 55 in 138(69%), 42(21%), 175(87.5%) respectively. Intact PTH was less than 100 pg/ml in 16(8.0%) patients supporting adynamic bone disease according to KDOQI guidelines and rest of the patients 184(92%) were having Intact PTH more than 100 pg/ml.

Conclusion: In this study, most of the patients were anemic most probably due to low dose of EPO and inadequate dialysis. High turnover and mixed bone disorders were present in majority of the patients.
Opinion: Peritoneal Dialysis In Pakistan: An Insider’s View. State of Affairs and Planning?
Authors: Qayyum Ahad
Published: October 2021

Pakistan has an estimated population of 212 million while the incidence of end stage renal disease in Pakistan is 100 patients per million; hence approximately 22,000 patients require maintenance dialysis to sustain life in our country. Remarkably peritoneal dialysis (PD) as a form of maintenance renal replacement is utilized in less than one per cent of these patients.  In the absence of a formal dialysis registry, we place the total number of chronic ambulatory peritoneal dialysis patients (CAPD) in Pakistan at approximately 76 excluding holiday patients who are visiting from abroad (*This figure was estimated by enquiring the total number of patients each PD units care in Pakistan. This figure was corroborated with the sole distributor of CAPD fluids in Pakistan.).
Peritoneal Dialysis Catheters, Insertion Methods and Complications
Authors: Paudel Klara
Published: October 2021

The success of peritoneal dialysis (PD) and the PD program lies in a well-functioning catheter without infections. There are various types of catheters available and various insertion methods, although the difference in function and the outcome results are not markedly differentiated. In this review the types of commonly used peritoneal catheters and the variety of insertion methods will be introduced, along with special techniques and special catheters. This article will also list the complications that arise early, within 30 days of insertion. Comparing the main standard catheter variations and insertion methods, there is no difference in function and complications.
Peritoneal Dialysis Related Infection – Peritonitis Management and Prevention
Authors: Brown Edwina A
Published: October 2021

Peritonitis is one of the major risks of peritoneal dialysis (PD) causing signiﬁcant morbidity and in some instances, mortality. It is one of the principal causes of transfer to hemodialysis (HD).  Peritonitis rates should be audited by units.  The recommended rate by the ISPD is less than 0.5 episodes/year
Nutritional Status of Patients on Maintenance Hemodialysis as Assessed by Mini Nutritional Assessment Survey- Short Form and Anthropometric Measurements.
Authors: Rizvi Nabiha , Baig Moeena
Published: October 2021

Protein calorie malnutrition is common in chronic kidney disease patients especially on maintenance hemodialysis (MHD). Multiple factors including mainly frequency and adequacy of dialysis and dietary habits may result in malnutrition besides other comorbidities. Different tools have been designed to analyze the nutritional status of dialysis patients including subjective global assessment, malnutrition inflammation score, Mini Nutritional Assessment– Short Form (MNA-SF) and several others. We assessed the nutritional status of our MHD patients using Mini Nutritional Assessment–Short Form (MNASF)

Methods

Total of 44 patients aged between 13 to 64 years, undergoing MHD for at least 6 months were included in the study.

Results

Out of 44 patients 63% patients were malnourished, 34% were at risk of malnutrition and 3% were having normal nutritional status according to MNA-SF. The mean of mid-arm circumference was low even in the presence of mean albumin and BMI within the normal range.

Conclusion Nutrition is a neglected aspect of the dialysis patients. Multiple factors including poor socioeconomic status, lack of knowledge and poor dietary compliance lead to significant malnutrition among MHD patients.
Impact of Poverty on Quality of Education in Haiti
Authors:   University of Haiti, Gedro Dube Moffatt
Published: October 2021

Education is among the critical needs besides the food, shelter and clothing in modern life. Quality education is an effective tool for minimizing poverty and joblessness, enhancing health and dietary standards, and attaining lasting growth. Hence, the study sought to determine the impact of poverty on the quality of education in Haiti. The study was a literature review based. The conclusions were based on reviewing previous studies. The study findings indicated that poverty influences the quality of education. The study noted the significance of education in developing countries could not be overstated. Quality education can be the catalyst needed to pull families and communities out of the cycle of poverty. Knowledge gives children the power to dream of a better future and the confidence required to pursue a complete education, which will help generations to come. The study further ascertained that education makes a significant difference for adults, particularly in day-to-day life, including nutrition, healthcare and gender equity. The poverty levels are potent in influencing the quality of education that the students will receive in the long run. The study recommended adequate mechanisms to ensure the government support children from a poor background. Addressing the academic difficulties children from deprived families will undoubtedly need a broader and bolder method to education policy than the current initiatives to reform schools. The government should make sure that school-age children are enrolled right into compulsory and free primary education. Given that education is a powerful device for minimizing poverty and joblessness, enhancing health and dietary requirements, and attaining sustainable advancement, the Haitian government must inject much more revenue in the education sector, mainly for the poor children to obtain a quality education. The government is required to make sure all learners within its nation have access to education both in rural and in metropolitan places. Keywords: Poverty, Quality of Education, Haiti
SIMULTANEOUS ESTIMATION AND VALIDATION OF RAMIPRIL AND TELMISARTAN BY UV SPECTROPHOTOMETRY
Authors:   Department of Pharmaceutical Chemistry, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522 019, AP India., Rambabu R , Vidyadhara S , Subbarao J
Published: October 2021

A simple and sensitive spectrophotometric method for the determination of ramipril and telmisartan in pharmaceutical dosage forms has been developed. The absorption maxima were found at 220nm for ramipril and 297nm for telmisartan using 0.1N NaOH as solvent. Beer’s law was obeyed for both the drugs in the concentration range of 2-10μg/ml with correlation coefficients 0.999 for both ramipril and telmisartan. The limits of detection for ramipril and telmisartan were found to be 0.142 and 0.405μg/mL respectively and the limits of quantitation were 0.43 and 1.22μg/mL. Accuracy of the method was verified by performing recovery studies using simultaneous equation method and found to be 98.33 to 99.54%w/w for ramipril and 99.36 to 99.82 %w/w for telmisartan. %RSD of repeatability and intermediate precision studies were found to be <2 for both the drugs. Ruggedness of the method was checked by changing analyst worked and instrument used. In both the cases, the %RSD was found to be less than 2.
DEVELOPMENT OF HINGWASTAK CHURNA GRANULES AND TABLETS BY DRY GRANULATION TECHNIQUE FOR IMPROVING PATIENT COMPLIANCE
Authors:   Kopparam Manjunath, Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, Tumkur - 572 102, Karnataka, India., Kopparam M , Kumar TV , Anantha Narayana DB , Nandeesh R
Published: October 2021

Ayurvedic formulary of India specifies the dose of Hingwastak churna to be 3-6 grams per day. It is difficult to swallow churna for patients. The objective of the present study was to develop Hingwastak churna granules and tablets with addition of organoleptic additives to improve the patient compliance. Granules and tablet formulations were developed by dry granulation (slugging) technique using different binders and other excipients. The granules were evaluated for angle of repose, tapped densities, compressibility index, organoleptic studies and stability study. The tablets were evaluated for weight uniformity, thickness, hardness, friability and disintegration time. Among the binding agents used 10% Avicel, CaCO3 and starch produced better granules with sufficient hardness and good flow properties. All the volunteers concurrently accepted the taste of Hingwastak churna granule formulation. Suitable formulation strategy can overcome the existing problem of Hingwastak churna.
FORMULATION AND STATISTICAL OPTIMIZATION OF MULTIPARTICULATE LAFUTIDINE-LOADED GASTRORETENTIVE DELIVERY SYSTEM USING 32- FACTORIAL DESIGN
Authors:   Department of Pharmaceutics, Kamla Nehru College of Pharmacy, Butibori, Nagpur - 441 108, (MH) India., Sapate K.A , Dangre P. V. , Godbole M. D.
Published: October 2021

The purpose of this research was to develop and optimize buoyant beads containing lafutidine by ionic-gelation method for gastroretentive delivery. The effect of two independent process variables like NaHCO 3: Polymer, Drug: Polymer ratio on % drug entrapment, % swelling and % drug release of buoyant beads containing lafutidine was optimized using 32 factorial designs. The observed responses coincided well with the predicted values, given by the optimization technique. The optimized beads showed drug entrapment efficiency 78.76+0.27%, swelling 69.90+0.13%, cumulative drug release 69.00+0.36% after 8 h; the average size of all buoyant beads ranged from 1.35+0.01 to 1.56+0.05 mm. The buoyant beads were characterized by SEM, DSC and FTIR spectroscopy for surface morphology and excipient-drug interaction analysis, respectively. All these beads showed prolong release of lafutidine over 8 h in 0.1 N HCl (pH1.2) evaluation of buoyancy of the optimized formulation in vivo in human volunteers showed that the beads were buoyant in gastric fluid for 8 h both in fasted and fed state.
NEW VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Authors:   Department of Pharmaceutical Sciences and Quality Assurance, Aditya Institute of Pharmaceutical Science and Research, Suramopalem, Kakinada - 533 347, EG Dist., AP, India., Vishalakhi T. , Kumar S. K , Sujana K , Rani P
Published: October 2021

A simple validated RP HPLC method for the estimation of rizatriptan benzoate in pharmaceutical dosage form and bulk was developed for routine analysis. This method was developed by selecting Agilent TC C18 (250 x 4.6 mm, 5 μ) column as stationary phase and acrylonibrile:water (45:55), pH adjusted to 3, as mobile phase. Flow rate of mobile phase was maintained at 4: 1 mL/min at ambient temperature throughout the experiment. Quantification was achieved with ultraviolet (DAD) detection at 220 nm. The retention time obtained for rizatriptan was 2.8 min. The detector response was linear in the concentration range of 2-25μg/mL. This method was validated and shown to be specific, sensitive, precise, linear, accurate, rugged and robust. Hence, this method can be applied for routine quality control of rizatriptan benzoate in dosage forms as well as in bulk drug.