bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral manifestations in crohn’s disease patients (scoping review)
Authors: Chamilia Chantika Alya , Nova Fitri Andrian
Published: November 2024

Background: Crohn's disease is an autoimmune disease that can affect all parts of the digestive tract, from the mouth to the anus. Manifestations of Crohn's disease are found in the liver, skin, joints, eyes, bile ducts, and the oral cavity. Up to 60% of cases found, oral manifestation occurred before the gastrointestinal tract is involved. Purpose: The aim of this study is to determine the oral manifestations found in Crohn’s disease patients. Method: This is an observational descriptive study with a scoping review method using the PRISMA diagram as a guideline. There are four electronic databases used for data collection which are, PubMed, Wiley Online Library, Unbound MEDLINE, and TripDatabase. Results: From this study, there are 18 types of oral manifestations found in Crohn's disease patients which are lip swelling (66,6%), aphthous stomatitis/mouth ulcer (55,5%), angular cheilitis (38,8%), gingival manifestations (38,8%), cobblestone (27,7%), periodontal disease (11,1%), redness of the soft palate (5,5%), plaques of pink papules in the posterior buccal mucosa and retromolar pad (5,5%), ulceration on the uvula, pillars of fauces and posterior pharyngeal wall (5,5%), hyperplasia palatal mucosa (5,5%), caries (5,5%), mucosal tag (5,5%), perioral edema (5,5%), perioral erythema (5,5%), apical periodontitis (5,5%), recurrent tonsillitis (5,5%), and enamel hypoplasia (5,5%). Conclusion: The four most common oral manifestations in Crohn’s disease are lip swelling, aphthous stomatitis, angular cheilitis, and gingival manifestations.
The Effects of Socialization Tactics on Graduate Employability and Organizational Commitment Among Malaysian Newcomer Employees
Authors:   National University of Malaysia, Malaysia, Yusri Yusmariaziani , Mokhtar Daniella ,   Faculty of Social Sciences and Humanities, National University of Malaysia, Malaysia
Published: November 2024

Despite the growing interest in organizational socialization tactics, research on this topic remained in its infancy and required further in-depth study, particularly in Malaysia. Especially in the case of newly graduated newcomers. Current research aimed to study socialization tactics’ influence on graduates’ employability and organizational commitment among newly graduated newcomers in Malaysia. The data for this study were gathered from 401 Malaysian respondents with varied career backgrounds. The snowball sampling technique and convenience sampling were used for data collection. Through Pearson correlation and multiple regression analysis via SPSS Version 26.0, socialization tactic dimensions were found to significantly predict graduate employability dimensions and organizational commitment (p < .01) except continuance commitment (p > .01). The current finding has added a fresh perspective on socializing tactic affects within Malaysian newly graduated newcomers’ settings. This was expected to be beneficial not only to Malaysian organizations but also to recently graduated newcomers themselves.
Use of multivariant enzyme-linked immunosorbent assay (ELISA) in the diagnosis of autoimmune bullous disorders in a resource-limited setting: A single-center experience
Authors: Kumar Vinod , De Dipankar , Gupta Smriti , Narayan R Vignesh , Mahajan Rahul , Chatterjee Debajyoti , Handa Sanjeev
Published: November 2024

Background

Autoimmune blistering disorders (AIBD) result from the formation of auto-antibodies against adhesion proteins of the skin/mucosa(e). These auto-antibodies can be detected in the bound form in the tissue using direct immunofluorescence (DIF) or blood circulation using enzyme-linked immunosorbent assay (ELISA) or other methods.

Objectives

The objective of this study was to evaluate the concordance rate between the results of multivariant ELISA and the diagnosis of AIBD made using DIF and histopathology in an appropriate clinical context.

Methods

This was a retrospective study (December 2020 to April 2023) in which the multivariant ELISA assay (able to detect antibodies against desmoglein 1, desmoglein 3, BP180, BP230, envoplakin, and collagen VII) data were retrieved from the dermatology laboratory. Corresponding clinical and histopathology data were searched from relevant institutional databases. As per routine practice, the final diagnosis was assigned based on the clinical presentation, histopathology features and corresponding DIF report.

Results

After screening the records of 338 patients during the study period, 253 patients were included. Of them, 194 had AIBD and 59 had non-AIBD. In the autoimmune blistering disorder group, 122 and 72 patients had pemphigus and pemphigoid, respectively. Overall, a good level of agreement was found between multivariant ELISA results and the final diagnosis (Fleiss kappa = 0.631, p-value < 0.001). The pemphigus vulgaris group exhibited good agreement (kappa = 0.796, p < 0.001), while pemphigus foliaceous, bullous pemphigoid and non-autoimmune blistering disorders demonstrated moderate agreement (kappa = 0.641, 0.651, 0.533, respectively; p < 0.001). The mucous membrane pemphigoid group had a fair agreement (kappa = 0.289; p < 0.001).

Limitations

The limitations for the study were its retrospective design, fewer number of patients in certain groups like paraneoplastic pemphigus and gold-standard single antigen specific ELISA was not done.

Conclusion

Considering good agreement between the multivariant ELISA and the gold-standard diagnosis (clinical findings plus histopathology plus DIF), multivariant ELISA can be used for the diagnosis of AIBDs in places where facilities for DIF are unavailable. Multivariant ELISA can improve etiological diagnosis for a set of autoimmune blistering disorders whose target antigens are represented in the multivariant panel.
Effect of health education on acceptance of human papilloma virus vaccine among parents of adolescent girls of Bishnupur, Manipur: A quasi-experimental study
Authors: Dhinu K. , Fernandez Sandra , Gupta Avantika , Elangbam Vijaya
Published: November 2024

Background & objectives

India contributes maximum to world’s cervical cancer burden. Prevention through vaccination is one of the pillars of the global strategy adopted by the World Health Organization (WHO) for the elimination of cervical cancer. Uptake of human papillomavirus (HPV) vaccine, which is about to be introduced in Universal Immunization Programme can be predicted by assessing its acceptance.

Methods

A quasi-experimental study was conducted among parents of adolescent girls of Bishnupur from February to May 2023 to evaluate the effect of a one-on-one health educational intervention programme on acceptance of the HPV vaccine. Data were collected by face-to-face interviews using a structured questionnaire based on the Health Belief Model from 70 participants selected through convenience sampling. Participants who responded ‘definitely yes’ to getting their daughters vaccinated with the HPV vaccine were considered as ‘vaccine acceptant’. Health education comprised three sessions two wk apart. Descriptive statistics, Cochrane’s Q and ANOVA were applied using SPSS 26.

Results

The median age of the participants was 38 (IQR: 34-44) yr, and 77.1 per cent were females. HPV vaccine acceptance improved significantly over time from 61.4 to 81.4 to 88.6 per cent (P=0.001), respectively. On application of repeated measure ANOVA, perceived benefits of vaccination (P<0.001) and perceived susceptibility to disease (P<0.001) improved significantly across the three time points, whereas perceived severity (P=0.051) and perceived barriers (P=0.367) did not.

Interpretation & conclusions

Health education intervention was effective at improving vaccine acceptance. Awareness programmes before the rollout of HPV vaccination and continuous re-enforcement would improve parents’ perceived benefits and thereby potentially increase vaccine coverage.
Spiritual Intelligence and Spiritual Care in Nursing Practice: A Bibliometric Review
Authors: Stiliya Jos K , Antony Janis Maria , Joseph Jasmine
Published: November 2024

Spiritual intelligence (SI) has recently gained traction in various fields, including nursing. Given the increasing emphasis on patient-centred care and the holistic well-being of patients and nurses, SI is particularly relevant in nursing practice. A bibliometric analysis of recent publications (2014–2024) in the field helps synthesise and evaluate the existing research on SI in the general field of nursing, identify literature gaps, suggest future research directions and raise awareness of the importance of SI in nursing practice. The present study reports bibliometric data (n = 461) from the Scopus database on SI, spiritual quotient and spiritual care in nursing and health care. The data are analysed using MS Excel and VOSviewer software. The publications’ trend analysis revealed a significant increase in SI-related publications since 2015. The study presents top-cited articles. Journal of Religion and Health was found to be a prominent journal with the maximum number of publications, and Sage was found to be the top publisher of journals with articles on SI. Network visualisation reveals central figures such as Wilfred McSherry, Trove Giske, Elizabeth Johnston Taylor, Fiona Timmins, Silvia Caldeira and Linda Ross as key researchers in the field. The United States and Iran have the most substantial connections of authors publishing on SI. This study reveals an increasing interest in SI and care within nursing research, confirming its growing significance in the field. By reporting areas where research on SI in nursing remains underdeveloped, the study paves the way for the development of new or updated curricula in nursing programs. The study can guide faculty development initiatives by highlighting the importance of SI and providing resources for educators to incorporate these concepts into their teaching. This study presents specific research questions to address these knowledge gaps. Future studies which can address these questions will enrich nursing education and practice, leading to improved patient outcomes and enhanced nurse well-being using the full potential of SI in nursing practice.
An infected intracranial dermoid cyst at the region of torcular herophili: A case report
Authors: Pahari Soumya , Bhandari Paawan Bahadur , Sharma Muna , Baniya Purushottam , Devkota Deekshya , Jha Rahul , Subedi Prarthana
Published: November 2024

Background:

Dermoid cysts result from embryonic fusion anomalies, with intracranial dermoid cysts being rare (0.1–0.7% of intracranial tumors). Often asymptomatic, they can manifest as midline swelling, headaches, seizures, or cerebral ischemia. Recognition and management are crucial for mitigating complications and ensuring favorable patient outcomes.

Case Description:

A 14-year-old girl presented with swelling at the occiput for 3 months. Initial imaging was suggestive of an extra-dural abscess in the occipital region with surrounding bone erosion. An infectious workup, including tests for tuberculosis, was non-contributory. A suboccipital craniectomy was done. On lifting, the bone flap, thick, purulent, and sebaceous contents with hair were spotted, which was adherent to the inner table of the skull and the dura overlying the torcular herophili, suggesting an infected dermoid cyst. A near-total excision was done, and culture-directed antibiotics were given. Postoperatively, the child made a complete recovery.

Conclusion:

The diagnosis of a dermoid cyst must be kept in mind, and it should be considered in the differential diagnosis of midline posterior fossa lesions. The risk of postoperative recurrence from incomplete excision should be weighed against the risk of injuring the venous sinuses during the extensive resection of dermoid cysts adherent to the torcular region.
Rare case of resistant Achromobacter xylosoxidans-associated meningitis due to intrathecal catheter
Authors: Nair Ajay , Lucarelli Vito , Hoyt Alastair
Published: November 2024

Background:

Achromobacter xylosoxidans (AX) is an aerobic Gram-negative opportunistic bacteria known to inhabit various environments and is most commonly associated with nosocomial infections in immune-compromised patients. Although rare, AX can cause a variety of neurological infections, such as meningitis, ventriculitis, and osteomyelitis. Intravascular catheters, intrathecal pumps, and contaminated surgical instruments are potential vectors for such patients.

Case Description:

Here, we present a unique case of multidrug-resistant AX-positive meningitis secondary to infection of a nonfunctional intrathecal narcotic pump. The patient has a complex past medical history leading up to infection, and care was significantly compromised by homelessness and inflammatory bowel disease (IBD). Treatment included catheter removal and antibiotics.

Conclusion:

Patients who suffer from homelessness or IBD show a possible increased risk of this infection. This case emphasizes the need for increased care regarding these patients, along with describing the complications and timeline when treating this rare type of meningitis.
Effectiveness of super-selective digital subtraction angiography and 3D rotational digital subtraction venography for a developmental venous anomaly with an arteriovenous malformation: A case report and literature review
Authors: Shiraishi Yuki , Neki Hiroaki , Maruyama Gakuji , Nonaka Yuko , Tokuyama Tsutomu , Tenjin Hiroshi , Saito Osamu , Kurozumi Kazuhiko
Published: November 2024

Background:

Arteriovenous malformation (AVM) and developmental venous anomaly (DVA) rarely coexist. Developing a surgical strategy to treat this co-occurrence is difficult due to the unclear pathogenesis. We report the use of super-selective digital subtraction angiography (DSA) and Three-dimensional (3D) rotational digital subtraction venography (DSV) to develop a surgical strategy for complex AVM draining into a DVA.

Case Description:

A 58-year-old woman presented with left hemiparesis and unconsciousness. Plain and contrast computed tomography showed a right frontal subcortical hematoma and a heterogeneous contrast lesion anterior to the hematoma, leading to a dilated vessel. The hematoma was removed due to worsening unconsciousness. DSA revealed a right frontal AVM of Spetzler-Martin grade 2 with superficial drainage into a DVA, and 3D-DSV revealed that the intermediate part of the DVA involved normal parenchyma. Interventional transarterial embolization and surgical nidus removal were planned. Preoperative super-selective DSA showed two medullary veins draining from the AVM into the DVA. Thus, we decided to separate the two medullary veins from the nidus. Postoperative angiography revealed complete removal of the AVM and preservation of the DVA.

Conclusion:

Treating a complex AVM draining into a DVA is challenging; surgeons have to remove only the AVM portion and preserve the DVA. Super-selective DSA and 3D rotational DSV were performed to develop the surgical strategy.
ИНТЕГРАТИВНЫЙ ПОДХОД В ОБУЧЕНИИ ИНОСТРАННОМУ ЯЗЫКУ С ИСПОЛЬЗОВАНИЕМ КОМПЬЮТЕРНЫХ ТЕХНОЛОГИЙ
Authors: О.В. Костоломова
Published: November 2024

В настоящей статье автор исследует особенности реализации интегративного подхода в обучении иностранному языку с использованием ИКТ-инструментов. Для этого автор анализирует основные характеристики актуальных процессов цифровизации, уделяя особое внимание применению ИКТ в рассматриваемой области. Также автор приводит конкретные практические примеры, разбирает реальные ситуации использования в обучении иностранному языку ИКТ-инструментов.
ПРАВОВАЯ И ЭКОНОМИЧЕСКАЯ ЭФФЕКТИВНОСТЬ ПРОГРАММЫ РЕНОВАЦИИ ЖИЛИЩНОГО ФОНДА
Authors: И.М. Лебедев , П.А. Заболотнева
Published: November 2024

Программа реновации действует в Москве с 2017 года и продолжает набирать обороты. Программа правительства Москва направлена на снос ветхого малоэтажного жилого фонда, построенного в 1957—1968 годах. В программу включено 5175 домов и под расселение попадут более 1 миллиона горожан. У многих возникают вопросы: действительно ли реновации – это решение проблем ветхого жилья? Выгодно ли это экономически и для кого? Экологичен ли снос старых домов? Законна ли реновация с правовой точки зрения? Статья посвящена анализу правовой и экономической эффективности оптимизации городского пространства с помощью реновации жилищного фонда.
3D ПЕЧАТЬ, КАК НОВЫЙ МЕТОД СТРОИТЕЛЬСТВА
Authors: Мавед Салех Эль
Published: November 2024

В статье рассмотрены современные цифровые технологии в строительной отрасли, таких как 3D-печать. Выявлена актуальность внедрения 3D-печати в строительную отрасль, которая заключается в возможности сокращения сроков строительства, трудозатрат на производственные процессы и увеличение качества зданий и сооружений.Рассмотрена история 3D-печати, ее характеристика. А также принципы работы 3D-принтера. Выявлены преимущества и недостатки использования данного метода строительства. Рассмотрены прогнозы структуры рынка 3D-технологий на 2025 год.Сделан вывод, что с каждым годом технологии 3D-печати становятся более востребованы, так как они предоставляют возможность сократить сроки строительства, а также сократить затраты на производственные процессы. Но несмотря на преимущества применения 3D-печати в строительной сфере существует ряд проблем, которые могут привести к упадку экономики страны.
РЕГИОНАЛЬНЫЙ БИЗНЕС В КОНТЕКСТЕ ИНСТИТУЦИОНАЛЬНЫХ ИЗМЕНЕНИЙ ЭКОНОМИКИ РФ
Authors: С.А. Барбашова , О.А. Бурмистрова , М.Н. Торгашин
Published: November 2024

Рассматриваются основные направления развития регионального предпринимательства в условиях импортозамещения на основе финансовой диагностики основных показателей деятельности организаций малого и среднего бизнеса. В ходе анализа исследуется зависимость хозяйствующих субъектов от внешних источников финансирования, предлагаются основные каналы поступления финансовых ресурсов, как за счет собственных, так и за счет заемных источников. Апробированы внедряемые меры по поддержке экономики РФ на современном этапе развития.
ВЛИЯНИЕ КОРОНАВИРУСА COVID-19 НА МИРОВОЕ СООБЩЕСТВО
Authors: Е.И. Дмитриева , Е.В. Быковская
Published: November 2024

В статье рассматриваются влияние и последствия коронавируса COVID-19 на мировое сообщество. Целью исследования является анализ социально-экономических последствий распространения COVID-19 и особенностей их влияния на состояние и развитие мирового хозяйства. При проведении исследования был задействован комплекс методов практического анализа, включая анализ статистических данных, прогнозных оценок изменения темпа роста ВВП, а также макроэкономическое моделирование возможных последствий коронавирусной эпидемии на состояние и развитие мировой экономики. Результатом исследования является выявление особенностей текущей ситуации, а также определение экономических и социальных изменений, происходящих в мировой хозяйственной системе. В качестве вывода следует отметить, что в новых формирующихся условиях национальным правительствам и международным институтам важно быстро и качественно реагировать на глобальные вызовы и угрозы, с которыми столкнулся современный мир.
ПРИМЕНЕНИЕ ИННОВАЦИОННЫХ ТЕПЛОИЗОЛЯЦИОННЫХ МАТЕРИАЛОВ ДЛЯ ЦЕЛЕЙ СНИЖЕНИЯ ТЕПЛОВЫХ ПОТЕРЬ НА ОБЪЕКТАХ КАПИТАЛЬНОГОСТРОИТЕЛЬСТВА
Authors: Е.А. Дядькова , В.М. Головенко
Published: November 2024

В статье авторами рассмотрен вопрос применения инновационных теплоизоляционных материалов для целей снижения уровня тепловых потерь в законченных строительством зданиях и сооружениях. Изучены критерии, которыми должны обладать теплоизоляционные материалы. Приведены статистические даны об уровне тепловых потерь в строительных объектах. Авторамирассматриваются инновационные материалы, используемые при строительстве зданий и сооружений для их теплоизоляции, а также основные преимущества и недостаткитаких материалов. Сделан вывод о том, что снижения уровня тепловых потерь, а как следствие и минимизации финансовых затрат от их возникновения, можно добиться применения современные теплоизоляционные материалы.
ЭКОНОМИКО – ПРАВОВЫЕ СПОСОБЫ ЗАЩИТЫ ВОДНЫХ РЕСУРСОВ. ОПЫТ ЕС
Authors: И.М. Лебедев , Е.Д. Исмагилова
Published: November 2024

в статье рассматриваются экономические и некоторые международно – правовые особенности по сохранению водных ресурсов от загрязнения, как основы жизнедеятельности общества и человечества в целом. Также приводятся примеры по экономическому и правовому регулированию водопользования в странах ЕС трансграничных рек, а также опыт России по сохранению водных ресурсов, о доступе к информации и охране окружающей среды. Рассмотрены компетентностные подходы к персоналу на предприятиях в рамках защиты вод. Рассматривается взаимодействие институтов государственной власти, органов местного самоуправления и общественных организаций (в т. ч. международных) в сфере защиты окружающей среды и водных ресурсов. Рассматривается один из принципов международной охраны вод, как в странах Европы, так и России «загрязнитель платит», раскрывается его экономико – правовая сущность.
ПРИМЕНЕНИЕ МАРКЕТИНГОВЫХ ТЕХНОЛОГИЙ В СТРОИТЕЛЬНОЙ ОТРАСЛИ
Authors: Е.С. Пахоменко , И.И. Сучкова
Published: November 2024

В статье рассмотрены понятие маркетинговой деятельности, классификация, виды и уровни маркетинга. Выделены причины медленного темпа развития маркетинговой деятельности в строительной отрасли. Авторамиперечислены особенности маркетинговой деятельности в данной отрасли, а также ключевые инструменты маркетинга в строительстве.Проанализированы маркетинговые технологии, применяемые в данной отрасли, выделены наиболее подходящие для отдельных производственных процессов на предприятиях и отмечено их положительное влияниена деятельность организаций. Сделан вывод о том, что на сегодняшний день маркетинг в строительной отрасли является достаточно многосторонним, он играет важную роль в развитии строительного бизнеса и в увеличении конкурентоспособности отдельных предприятий.
АНАЛИТИЧЕСКИЕ ИНСТРУМЕНТЫ И МЕТОДЫ ДЛЯ ОЦЕНКИ КОНКУРЕНТОСПОСОБНОСТИ ПРОМЫШЛЕННЫХ КОМПАНИЙ
Authors: И.Н. Дмитренко , Д.В. Борщевич
Published: November 2024

Статья посвящена систематизации и рассмотрению наиболее адаптивных методов оценки конкурентоспособности промышленных компаний с учетом выявленных присущих им преимуществ и недостатков. Установлены несовершенства существующих подходов к классификации методов оценки конкурентоспособности. На основе компаративного и логического анализа авторами обозначены предпосылки, приведены аргументы в обоснование выбора оптимальных методов оценки конкурентоспособности компаний с учетом их отраслевой принадлежности. Акцентировано внимание на значении отраслевых особенностей при адаптации аналитических инструментов, что усиливает объективность результатов оценивания конкурентоспособности конкретных компаний. Приведены рекомендации по выбору наиболее адаптивных методов и инструментов оценки конкурентоспособности для угледобывающих компаний.
ИНФРАСТРУКТУРНОЕ ОБЕСПЕЧЕНИЯ УСТОЙЧИВОГО РАЗВИТИЯ ПРЕДПРИНИМАТЕЛЬСКОЙ ДЕЯТЕЛЬНОСТИ ПРИ РЕАЛИЗАЦИИ НАЦИОНАЛЬНОГО ПРОЕКТА «МАЛОЕ И СРЕДНЕЕ ПРЕДПРИНИМАТЕЛЬСТВО И ПОДДЕРЖКА ИНДИВИДУАЛЬНОЙ ПРЕДПРИНИМАТЕЛЬСКОЙ ИНИЦИАТИВЫ»
Authors: И.О. Толмачев , Е.Э. Дубовицкий , Е.Л. Дмитриева
Published: November 2024

В статье рассматриваются вопросы устойчивого развития предпринимательской деятельности в современных условиях. Проведен анализ реализации национального проекта «Малое и среднее предпринимательство и поддержка индивидуальной предпринимательской инициативы». Выявлены проблемы инфраструктурного обеспечения предпринимательства в регионах страны. Для преодоления существующих проблем в части инфраструктурного обеспечения предпринимательства и решения проблемы устойчивого развития предпринимательства необходимо совершенствование институциональной основы поддержки; стимулирование спроса со стороны предпринимателей на государственные услуги и развитие существующих предложений поддержки предпринимательства. Обосновано предложение об улучшении деловой среды для предпринимателей за счет ГЧП в указанной сфере.
ИНДИКАТИВНАЯ СОСТАВЛЯЮЩАЯ КАК РЕЗЕРВ ЭКОНОМИЧЕСКОГО РОСТА (НА ПРИМЕРЕ ТАМОЖЕННОЙ ОТРАСЛИ)
Authors: В.Н. Круглов , О.С. Шаурина
Published: November 2024

Актуальность затрагиваемой темы определяется тем, что система таможенных органов имеет первостепенное значение в обеспечении условий внешнеэкономической деятельности Российской Федерации и, в частности, международной торговли. Роль международной торговли в условиях глобализации имеет тенденцию к возрастанию, что влечет за собой возникновение определенных угроз экономической безопасности страны (например, контрабанда, вытеснение с рынка отечественных товаров и т.д.).  Следовательно, возрастает роль индикативных параметров в общем процессе. Без определения лабильности их значений само качество менеджмента может подвергаться сомнению. Поэтому авторы статьи при помощи методов индукции и дедукции, диалектического и историографического анализа, системного и процессного подходов пытаются найти и находят новые направления использования уже имеющихся индикаторов и внедрения их новых модификаций. Система многофакторных сравнений обеспечивают сделанным выводам достаточную доказательность, а значит, и убедительность.
ПОВЫШЕНИЕ КАЧЕСТВА АУДИТА КАК ОСНОВА РАЗВИТИЯ АУДИТОРСКОЙ ДЕЯТЕЛЬНОСТИ
Authors: Ш.И. Алибеков , В.В. Морунов , И.Ф. Нурмухаметов
Published: November 2024

В статье рассмотрен вопрос о роли, значении и влиянии Концепции качества аудита на развитие аудиторской деятельности, а также об особенностях изменения отечественного законодательства, регулирующего аудиторскую деятельность.
An individual approach to the diagnosis of uveitis of tuberculous etiology: from theory to practice
Authors:   The Moscow Research and Clinical Center for Tuberculosis Control, Moscow, Gamzaev M.G. , Buldakov I.A. ,   S.N. Fedorov NMRC «MNTK «Eye microsurgery», Moscow, Kozlova M.A. ,   The Moscow Research and Clinical Center for Tuberculosis Control, Moscow, Romanova D.A. ,   Pirogov Russian National Research Medical University, Moscow
Published: November 2024

Intraocular tuberculosis is a great mystifier of various forms of uveitis, and it should be put in the first row in the differential diagnosis of any type of intraocular inflammation, as well as clearly differentiate it from other etiologies of choroidal lesions, which presents certain difficulties due to the diversity, mosaic, and often atypical clinic of the tuberculosis process. The article presents a clinical observation of tuberculous uveitis in a 61-year-old patient D., which was well stopped by non-specific anti-inflammatory therapy and antibacterial drugs. When conducting and evaluating the results of additional studies, such as computed tomography of the chest and a highly specific TSPOT.TB test, the patient was suspected to have a latent tuberculosis infection in the patient. As a result, a test with recombinant tuberculosis allergen (ATR) was performed, as a result of which the authors received a pronounced focal reaction from the eye. Thus, for the first time in the world scientific community, a clinical picture of a pronounced reaction of the eye to an ATR test is presented, since at the moment there is no information among the available sources of domestic and foreign literature that describes the same reaction to an ATR test as in the presented clinical example. The authors note that the eccentricity of the course of tuberculosis of the visual analyzer obliges the doctor to correctly collect an anamnesis, choose current diagnostic methods, correctly evaluate their results and evaluate the effectiveness of anti-tuberculosis therapy.
Surgical treatment of a patient with acute mesenteric circulatory disorder and colon cancer complicated by acute intestinal obstruction
Authors:   St. Petersburg State Pediatric Medical University, St. Petersburg, Ruseva A.D. ,   Mariinsky Hospital, St. Petersburg, Solovev I.A. ,   St. Petersburg State Pediatric Medical University, St. Petersburg,   Mariinsky Hospital, St. Petersburg, Khanevich M.D. ,   St. Petersburg State Pediatric Medical University, St. Petersburg,   Mariinsky Hospital, St. Petersburg, Zinoviev E.V. ,   St. Petersburg State Pediatric Medical University, St. Petersburg,   Mariinsky Hospital, St. Petersburg, Khairov A.M. ,   St. Petersburg State Pediatric Medical University, St. Petersburg,   Mariinsky Hospital, St. Petersburg, Tlekhugova M.M. ,   St. Petersburg State Pediatric Medical University, St. Petersburg, Kayumova A.Sh. ,   St. Petersburg State Pediatric Medical University, St. Petersburg
Published: November 2024

A clinical case of colorectal cancer complicated by acute intestinal obstruction, combined with acute violation of mesenteric circulation, is presented. The patient was admitted to a multidisciplinary hospital in St. Petersburg in extremely serious condition. The examination revealed widespread peritonitis complicated by abdominal sepsis and septic shock. After the patient was brought out of critical condition, an operation was performed. The operation revealed cancer of the hepatic bend of the colon, complicated by acute intestinal obstruction and acute violation of mesenteric circulation. An extended hemicolectomy with resection of 1.5 m necrotically altered ileum was performed. In the postoperative period, the patient underwent program rehabilitation of the abdominal cavity. However, it was not possible to achieve successful treatment. The cause of death was massive bilateral thromboembolism of the pulmonary artery and its branches.
Long-term results of hybrid cardiac bypass and endovascular stenting in patients with hereditary hypercholesterinemia and angina
Authors:   Kursk State Medical University, Kursk, Sukovatikh B.S. , Sidorov D.V. ,   Kursk City Clinical Hospital of Emergency Medical Care, Kursk,   Oryol regional clinical hospital, Orel,   OGU named after. I.S. Turgenev, medical institute, Orel, Bolomatov N.V. ,   Kursk City Clinical Hospital of Emergency Medical Care, Kursk,   Pirogov National Medical and Surgical Center, Moscow, Sereditsky A.V. ,   Oryol regional clinical hospital, Orel,   OGU named after. I.S. Turgenev, medical institute, Orel, Vishnevsky V.I. ,   OGU named after. I.S. Turgenev, medical institute, Orel, Alyanov A.L. ,   Oryol regional clinical hospital, Orel,   OGU named after. I.S. Turgenev, medical institute, Orel, Karasev A.Yu. ,   Oryol regional clinical hospital, Orel,   OGU named after. I.S. Turgenev, medical institute, Orel, Shvets D.A. ,   Oryol regional clinical hospital, Orel, Sletova A.M. ,   Kursk City Clinical Hospital of Emergency Medical Care, Kursk, Gavrilina A.V. ,   Kursk City Clinical Hospital of Emergency Medical Care, Kursk, Orlova A.Yu. ,   Kursk State Medical University, Kursk,   Kursk City Clinical Hospital of Emergency Medical Care, Kursk
Published: November 2024

Purpose of the study. Comparison of the results of coronary stenting and coronary bypass surgery in patients with hereditary hypercholesterolemia and angina pectoris. Materials and methods. An analysis of the results of treatment of 100 patients with hereditary hypercholesterolemia and exertional angina was carried out. As part of the preoperative preparation, all patients were classified according to the SYNTAX Score – in all cases, moderate severity of the lesion was revealed. Based on this, before the 2nd stage of surgical treatment, all patients were randomly divided into 2 equal groups: Group 1 included patients who underwent endovascular revascularization of the affected coronary artery as the 2nd stage of surgery treatment; Group 2 included patients who underwent coronary artery bypass grafting (CABG) as the 2nd stage of revascularization. Results. The results of endovascular stenting and cardiac bypass surgery demonstrate almost identical results 12 months after surgical treatment and in patients with moderate severity of lesions according to the SYNTAX Score. The quality of life of patients who have undergone coronary artery stenting is much higher than that of patients who have undergone open cardiac surgery.
Early or delayed revascularization in patients with peripheral arterial disease: how to make the right choice?
Authors:   Almazov National Medical Research Center, St. Petersburg, Arutyunyan S.O. , Zhdanovich K.V. ,   Almazov National Medical Research Center, St. Petersburg, Puzdryak P.D. ,   Municipal Multi-Specialty Hospital №2, St. Petersburg, Gusinkiy A.V. ,   Almazov National Medical Research Center, St. Petersburg, Shlomin V.V. ,   Almazov National Medical Research Center, St. Petersburg, Kucherenko V.S. ,   Almazov National Medical Research Center, St. Petersburg, Fionik O.V. ,   Almazov National Medical Research Center, St. Petersburg
Published: November 2024

Peripheral artery bypass surgery can be performed both in patients at the stage of claudication or in those who is suffering from critical limb ischemia (CLI). Patients with CLI have more severe stages of atherosclerosis and comorbidities as compared with patients at the stage of claudication, and tend to have a higher risk of amputation and death following revascularization of the lower limb. No comparison of primary surgery outcomes performed at the stages of claudication and CLI has been conducted so far. This study was based on different approaches to timing and techniques of peripheral artery bypass surgery and aimed at studying the results of revascularization procedures performed in patients with various stages of chronic lower limb ischemia. Materials and methods. The study included 88 patients who had undergone surgical revascularization. In 44 cases, the surgical procedures were performed at the CLI stage and 44 cases – at the stage of claudication. Similar techniques of revascularization were used in both groups, including conventional (bypass surgery, endarterectomy) and endovascular procedures (angioplasty or stenting). The outcomes of revascularization procedures were evaluated within the first 30 days after the surgery. Results. Clinical improvement after the surgery was more commonly observed in the claudication group (93%) compared with the CLI group (75%). The rate of complications in the CLI group (59%) was in 5 times more that in the claudication group (9%). Conclusions. Timely performed surgical revascularization for limb ischemia in patients with rapidly progressing peripheral arterial disease can contribute to lower rate of complications and amputations and better clinical outcomes.
New and de novo Biallelic Variant Associated with Owren’s Disease: Precision Medicine in Coagulation Disorders
Authors:   Resident Specialization in Pediatrics, Universidad Libre seccional Cali, Colombia, Jimenes Michel Alejandra Ewonds , Giraldo Lina Johanna Moreno ,   Leader of the Neurogenetics and Metabolic Diseases Research Line (NEUROMET) of GRINPED
Published: November 2024

Introduction: Coagulation factor V deficiency, also called Owren’s disease or parahemophilia [1], is a genetic disease with an autosomal recessive inheritance pattern that causes moderate to severe bleeding [2]. It can be classified into type I when the deficiency is quantitative and type II when the deficiency is qualitative [3]. Currently, it is associated with variants in the F5 gene. According to recent database searches, 450 clinically significant variants and approximately 3942 variants related to the F5 gene have been identified [2].
Spatio-chemical deconvolution of the LiNi0.6Co0.2Mn0.2O2/Li6PS5Cl interphase layer in all-solid-state batteries using combined X-ray spectroscopic methods
Authors: Lelotte Barthélémy , A. F. Vaz Carlos , Xu Linfeng , Borca Camelia , Huthwelker Thomas , Vincent Pelé , Jordy Christian , Gubler Lorenz , El Kazzi Mario
Published: November 2024

The (electro-)chemical degradation at the interface between Li6PS5Cl (LPSC) and LiNi0.6Co0.2Mn0.2O2 (NCM622) is systematically investigated using non-destructive synchrotron X-ray absorption spectroscopy (XAS) and X-ray photoemission electron microscopy (XPEEM). These techniques provide surface chemical depth profiling (from 2 nm to several hundred nm) and high-resolution elemental imaging of both LPSC and NCM622 particles. This analysis was complemented by galvanostatic cycling, impedance spectroscopy, and operando cell pressure measurements. Several correlations between interphase evolution and cell electrochemical performance are clarified, while some inconsistencies are rationalized and discussed. Firstly, the intrinsic LPSC electrochemical oxidation mechanisms were studied using an LPSC:C65 working electrode. The results showed that increased cell resistance during the first charge stemmed from polysulfide by-products and particle contact loss due to LPSC volume shrinkage at the interface. Secondly, when using an NCM622:LPSC working electrode, species such as sulfites, sulfates and phosphates, were detected on both LPSC and NCM622 particles, while electrochemically inactive reduced transition metals (TMs) were observed only at NCM622 surfaces. These species, initially present at open circuit potential, increased after the first charge, due to the chemical reactions between LPSC and NCM622 surface lattice oxygen. The estimated interphase thickness on the LPSC and NCM622 surface over the cycling remains below ⁓3 nm. Our findings highlight that the formation of an electrochemically inactive NCM622 surface is a primary cause of impedance rise during the first charge, along with the formation of LPSC by-products and contact loss. However, the continuous increase in cell resistance could not be attributed to further interphase growth after the first charge. We hypothesize that this may result from slow and progressive LPSC polymerization reactions (e.g., form Li2PS6 and P2S5) and structural changes at the NCM622 surface.
Toward AI/ML-assisted Discovery of Transition Metal Complexes
Authors: Jin Hongni , Merz, Jr. Kenneth M.
Published: November 2024

Traditional computational methods for molecule design are based on first principles calculation, which places a high demand on computing power. The increasingly powerful machine learning (ML) models have fundamentally transformed this landscape. Statistically, by learning the joint probability distribution between molecular or material structure and targeted properties, generative models can autonomously design numerous novel structures with satisfactory properties. This inverse design strategy clearly outperforms the traditional physics-based methods which requires human expertise and intuition, along with serendipity. To validate the generated molecules or materials for specific properties, classical discriminative models allow for fast large-scale screening of the quantitative structure-activity relationships. Generally, the completely ML-based workflow from generation to validation for the exploration of chemical space is accessible and provides outstanding benefits which traditional computational approaches struggle to achieve. In this review, we summarize recent advances in ML-assisted discovery for transition metal complexes and conclude with several existing challenges which impede the widespread practical applications of this technology to the class of problems.
Electric Vehicle Pattern-based Battery Cycling Dataset and Its Application in Predicting Rapid Degradation
Authors: Lee Jaewook , Jegal Seonyoung , Chung Mikyung , Kim Seunghyun , Kim Min Jun , Koh Dong-Wook , Lee Jay H.
Published: November 2024

Previous studies aimed at predicting the lifetime of lithium-ion batteries often rely on cycling data characterized by charge and discharge rates that do not reflect the typical usage conditions of electric vehicles (EVs), or they focus on batteries that degrade slowly, limiting their applicability to scenarios where batteries degrade more rapidly. This study introduces a new cycling experiment dataset that mirrors realistic EV charge and discharge profiles and includes conditions that simulate rapid pressure increases due to various side reactions or mechanical impacts.We establish a criterion for identifying cells that experience abrupt capacity fades. Utilizing a two-dimensional convolutional neural network, we accurately classify cells prone to rapid degradation using only the voltage, current and temperature data from the first 3 cycles, achieving over 99% accuracy. Furthermore, we predict the state of health (SOH) of each classified cell at 270 cycles with a root mean square error (RMSE) of less than 2%.
Phosphoryl-Deoxygenated Access to Cationic Phosphacycles Enabled by Intramolecular SEAr process of Pentavalent Phosphorus Cations
Authors: Haiyang Huang , Sun Longgen , Mei Zhichao , Bai Jiang , Chen Chao , You Mengyao , Wu Yanli , Ding Haixin , Xiao Qiang
Published: November 2024

Achieving a direct functionalization of phosphine oxides through the cleavage of the inert P=O double bond remains a formidable challenge in phosphorus chemistry. Herein, we reported a metal-free catalytic electrophilic aromatic substitution (SEAr) phosphacyclization, effectively transforming phosphine oxides into valuable cationic phosphacycles by introducing a powerful nucleofugality (-OTf) to promote the SEAr process via a formal P(v)-dication transition-state. Meanwhile, the theoretically calculated results indicate that the splitting P─OTf bond is pivotal to trigger the SEAr reaction of P(v)-cationic species. Moreover, the kinetic studies also verify that the generated acid (HOTf) would facilitate the nucleofugality leaving from the cationic P-center to accelerate the cyclization. In addition, we investigated their photophysical and electrochemical properties of some typical phosphacycles, which implied the fused di-cationic phosphacyles could be a class of potential optical function molecules. Summarily, this work not only extends the application boundary of phosphine oxides but also paves a way for effectively preparing various mono/di/tri-cationic phosphacycles.
Understanding the Finite Size and Surface Relaxation Effects on the Surface States of Bi2Se3 Family Topological Insulators
Authors: Weng Guorong , Alexandrova Anastassia N.
Published: November 2024

Topological insulators (TIs) of the Bi2Se3 family exhibit topological phase transition from three dimensional (3D) to two dimensional (2D) TIs in thin films with decreasing thickness. Understanding the driving force of this transition is critical for the applications of TIs in nanodevices. Herein, we investigate the finite-size effects on the bulk band inversion and the structural relaxation effects on the surface states within the Bi2Se3 family via first-principles calculations. Thin films exposing the three lowest-energy surfaces are modeled by 2D slabs with tunable thicknesses. We propose that the thickness dependence of the topological phase originates from electron confinement created by surface cuts. The increase in film thickness then counteracts these confinement effects, resulting in a monotonically decreasing band gap evaluated at the spin−orbit decoupled level. This dependence of the bulk gap on the thickness is found consistent for various surface slabs. We utilize this relationship to predict the required thickness for maintaining the 3D TI phase and 2D surface states. Our findings underscore the importance of electron delocalization in determining the topological phase of TI thin films. In addition, the actual manifestation of topological surface states on the side surfaces is affected significantly by the co-existing dangling bonds produced by surface cuts. Therefore, surface relaxation plays a crucial role in disentangling the trivial and nontrivial surface states.
Preparation of closo-decaborate by pyrolysis of tetraethylammonium borohydride: revision and optimization for large-scale production
Authors: Mishchenko Artem , Lishchenko Yulian , Kozytskiy Andriy , Konysheva Kateryna , Satska Yulia , Ryabukhin Serhiy , Volochnyuk Dmytro , Kolotilov Sergey , Rassukana Yuliya
Published: November 2024

Several methods for preparation of closo-decaborate (B10H102- as polyalkylammonium salts) – a key compound for synthesis of carborane – by pyrolysis of tetraethylammonium borohydride were examined. The studied reactions included variation of decomposition temperature, liquid medium, pressure and reaction time. The products were analyzed by 11B and 1H NMR spectroscopy, and, in some cases, by IR-spectroscopy. It was found that pyrolysis of Et4NBH4 in solid state as well as in suspension in silicone fluid led to the mixtures of (Et4N)2B10H10 and (Et4N)2B12H12. Pyrolysis of Et4NBH4 in n-decane or decalin resulted in Et4NB3H8 as a primary product; increase of reaction time in n-decane or both time and temperature in decalin yielded the mixture of (Et4N)2B10H10, (Et4N)2B12H12 and other compounds. It was shown that the degree of conversion of Et4NBH4 into Et4NB3H8 on time in n-decane at 174 °C and decalin at 180 °C linearly depended on time. Several methods for purification of (Et4N)2B10H10 or (Bu3NH)2B10H10 from other pyrolysis products were checked. A synthetic procedure for preparation of closo-decaborate from 60 g of Et4NBH4 was proposed, yielding 2.85 g of (Bu3NH)2B10H10 in one run.
High-resolution photoelectron spectroscopy of NO3− vibrationally excited along its 𝜈3 mode
Authors: Lau Jascha A. , DeWitt Martin , Franke Peter R. , Stanton John F. , Neumark Daniel M.
Published: November 2024

The nitrate (NO3) radical has long been the subject of both experimental and theoretical studies due to its complex electronic structure resulting from vibronic interactions between the 𝑋 ̃ 2𝐴′2 and 𝐵 ̃ 2𝐸′ states. In particular, the definite assignment of the fundamental of its degenerate stretching vibration (𝜈3) is still under debate. Here, we extend the available spectroscopic information by reporting high-resolution photoelectron spectra of vibrationally pre-excited NO3− using the recently developed IR-cryo-SEVI technique. The anions are excited through infrared (IR) excitation near 1350 cm−1, accessing the 𝜈3 and 2𝜈3(𝑒′) vibrational levels with band centers at 1350.5 cm−1 and ~2700 cm−1, respectively. The IR-cryo-SEVI spectrum for 2𝜈3 pre-excitation shows clear evidence for an intense 3_2^1 transition. From the position of this feature (30031 cm−1), the electron affinity of NO3 also determined in this work (31680 cm−1), and the IR excitation energy, we obtain a fundamental frequency of 1051 cm−1 for the 𝜈3 fundamental of the NO3 radical. This assignment and other features in the IR-cryo-SEVI spectra are supported by spectral simulations based on a vibronic Köppel-Domcke-Cederbaum Hamiltonian. The simulations also show that nearly all features in the IR-cryo-SEVI spectra arise because of pseudo-Jahn-Teller coupling between the 𝑋 ̃ and 𝐵 ̃ state of NO3. The results and analysis presented here settle a long-standing controversy regarding the 𝜈3 frequency of NO3.
Selective capture, isolation, and characterization of mucin foraging neu-raminidase-active bacteria from microbiomes using a non-inhibitory activ-ity-based probe
Authors: Shipman Kristina , Steiger Andrea , Ugwuoji Emmanuel , Webber Lucas , Anand Ashish , Wright Aaron
Published: November 2024

Neuraminidase is expressed by some bacteria in host-associated environments to cleave terminal sialic acid residues from mucin layers. This activity has been associated with nutrient acquisition, biofilm formation, and host infection, and is more prevalent in pathogens than commensal microbes. Since the integrity of the mucin layer in the airway and gastrointestinal tracts is a crucial part of the immune system, bacteria that degrade it through neuraminidase activity are of interest. We de-signed an activity-based probe (Neu-BDP) to detect neuraminidase-expressing bacteria without impacting functional activity. We show that by utilizing a quinone methide-based covalent trapping mechanism, Neu-BDP avoids inhibition of neuramini-dase while still maintaining high selectivity for target microbes. We envision that this approach for whole cell neuraminidase detection will enable future investigation of microbes associated with infection and colonization of the gut, airway, and other mucosal surfaces.