bluuebunny/crossref_metadata_2025 huggingface dataset:
Contacto entre o português e o espanhol: os falsos amigos nos manuais didáticos
Authors: Oliveira Dias Sofia
Published: September 2018

O interesse pela investigação no âmbito do contacto linguístico entre o português e o espanhol, tanto na Europa como no Brasil, quer no que diz respeito à didática das línguas estrangeiras, quer no mundo da tradução e da lexicografia, é cada vez maior, sendo o léxico uma das áreas a destacar. Dentro desta, os, assim conhecidos, “falsos amigos” constituem um dos temas que mais interesse tem suscitado no âmbito dos estudos contrastivos entre ambas as línguas. Neste artigo é nosso objetivo analisar a presença e a apresentação dos falsos amigos nos manuais de português como língua estrangeira para hispanofalantes.
Diversity and distribution of tree species in tropical forests of Northcentral Eastern Ghats, India
Authors: PREMAVANI D. , NAIDU M. TARAKESWARA , KUMAR O. ANIEL , VENKAIAH M.
Published: September 2018

Premavani D, Naidu MT, Kumar OA, Venkaiah M. 2017. Diversity and distribution of tree species in tropical forests ofNorthcentral Eastern Ghats, India. Asian J For 1: 27-32. The diversity and distribution of tree species were studied in three 1 ha sites oftropical forests in the northcentral Eastern Ghats of India. The phytosociological data from forest sites were analyzed quantitatively todetermine the basal area, species diversity, richness and stand density. A total of 1,507 individuals of 104 plant taxa, pertaining to 82genera under 41 families were enumerated at â‰¥15 cm gbh using belt transects (5 m Ã— 1000 m). Tree stand density varied from 371-660individuals per ha while average basal area ranged from 14.54 â€“ 46.51 m2 ha-1. Shannon-Weiner Index (H') ranged from 0.97-0.98,Equitability or evenness index ranged from 0.70-0.79 and Margalef richness index ranged from 10.54 â€“ 10.82. The most dominantfamilies were Rubiaceae, Euphorbiaceae, Fabaceae, Moraceae, and Verbenaceae. Our results suggest further development of forestmanagement and biodiversity conservation in Eastern Ghats region.
Review: Forest management and conservation practices in Ethiopia: Opportunities and constraints
Authors: AMENU BEKELE TONA
Published: September 2018

Amenu BT. 2018. Review: Forest management and conservation practices in Ethiopia: Opportunities and constraints. Asian J For 2: 77-82. Ethiopia has various and diversified natural resources. Forests are one of the most valuable resources of our physical environments. It is one of the natural resources that have several benefits for the society. It constitutes various social, economic, and other uses. This review identified that forests are an important part of our state's environment and economy. When it managed well, forests provide clean air and water, homes for wildlife, beautiful scenery, places for recreation and more than 5,000 products we all use every day. Forest resources and forest lands should be managed and used in sustainable basis to fulfill the social, economic, cultural and spiritual needs of the present and future generation. By its nature, forestry is concerned with maintaining the quality of various nonmarket benefits. In forest management, trees are harvested for a variety of reasons including improving the health of the forest; controlling the types of trees that grow on the site; attracting certain wildlife species; providing a source of income for the landowner; producing paper, lumber and numerous other forest products; and improving access to the area for hikers, hunters and other recreational users. There are varieties problems, constraints, and opportunities of forest conservation and management system Address poverty and forest governance by promoting forest ownership and access rights. Promote greater recognition of the rights of local and indigenous groups and give greater attention to land tenure, ownership, and rights-to-resource, the greatest biodiversity losses in the world have occurred through habitat losses. Conversely, the greatest opportunities for ecological restoration will occur through land abandonment, and access issues In addition to this, the social, economic constraints and socio-economic factors are the major problems. The major constraints or problems are adequate appreciation of the role and value of forest and in adequate investment in forestry sector under the state plan etc. (internet). Constraints and factors such as poor management plan, lack of good resource management plan and policy were the main factors and constraints of forest destruction.
Plant diversity of Betel Leaf Agroforestry of South Meghalaya, Northeast India
Authors: TYNSONG H. , TIWARI B.K. , DKHAR M.
Published: September 2018

Tynsong H, Tiwari BK, Dkhar M. 2018. Plant diversity of Betel Leaf Agroforestry of South Meghalaya, Northeast India. Asian J For 2: 1-11. Large areas of lowland tropical forests of South Meghalaya have been converted into betel leaf agroforestry systems by the tribal people living in the area. The betel leaf agroforestry with diverse and structurally complex shade canopies conserve a significant portion of the original forest biodiversity. The impact of land use change on the biodiversity was studied using standard vegetation analysis and biodiversity estimation methods. A total of 160 plant species were recorded in natural forests out of which 75 were trees, 40 shrubs, and 45 herbs, while in betel leaf agroforestry, a total of 159 plant species, 94 trees, 17 shrubs and 48 herbs were recorded. A total of 34 tree species, 13 shrub species, and 14 herb species were common in both the land uses. All the plant species were native species. The study revealed that the conversion of natural forest to betel leaf agroforestry in South Meghalaya has no significant impact on tree and herb diversity. However, the basal area and density are affected to some extent. The land use change has also affected the density and diversity of shrubs. The study concludes that betel leaf agroforestry in South Meghalaya developed by the indigenous War Khasi tribe through experiential learning over several generations has emerged as a fairly sustainable agroforestry system causing minimal impact on plant diversity.
Woody biomass and elements uptake in phytoremediation of compost leachate
Authors: ABEDI TOOBA , AVANI NAZI
Published: September 2018

Abedi T, Avani N. 2018. Woody biomass and elements uptake in phytoremediation of compost leachate. Asian J For 2: 20-24. This study examined the performance of absorption and growth of Alnus glutinosa and Taxodium distichum which underwent leachate irrigation of Rasht Compost Plant. In mid-March 2013, one year old seedlings of Alnus glutinosa and Taxodium distichum were planted in a greenhouse at Safrabaste Poplar Research Station and since then, this study began. The compost leachate was taken from the collection reservoir of leachate coming from open composting of organic municipal wastes and various gardening and plant wastes. Three treatments were applied to the plants, namely the irrigation using: tap water (control/C), pure leachate (P) and the mixture of one volume unit of leachate with one volume unit of running water (1: 1). It was concluded that leachate had a positive influence on the growth of A. glutinosa and T. distichum namely an increase in diameter and height of seedlings in the measurement period which occured to be caused by fertilization properties of leachate. Statistically, there was no difference in the development of aboveground biomass in the treatment of P, 1: 1 and C. This indicated that both irrigation by pure leachate and mixture liquid stimulate growth in the same way as irrigation by water. The dry mass of root showed the same result as aboveground mass. The total dry mass of the leachate treatment for A. glutinose and T. distichum were, respectively, 83.89 g and 78.68 g. The total root dry mass of leachate treatment for A. glutinosa and T. distichum was, respectively, 11.98 g and 9.09 g. The results of elements absorption showed no statistical difference between the aboveground species. The absorption of Ca concentration in root was higher than the absorption of other elements and showed significant difference in 1: 1 treatment.
The Revolution of Capitalist Relations Induced by the Technological Revolution of Electronics
Authors: Bruce E. Parry
Published: September 2018

Capitalism is in a dialectical leap to socialism, the next human stage. The laws of dialectical materialism and of historical materialism are examined. The scientific and technical revolution is examined. This revolution is creating a period of social revolution. Electronics is a labor-replacing technology, which destabilizes capitalism. Imperialism, globalization, and financialization are shown to be features of the current period, not stages of capitalism. The role of activists is outlined.
Swept-wavelength lasers based on GaSb gain-chip technology for non-invasive biomedical sensing applications in the 1.7–2.5 μm wavelength range
Authors: Vizbaras Augustinas , Šimonytė Ieva , Miasojedovas Arūnas , Trinkūnas Augustinas , Bučiūnas Tadas , Greibus Mindaugas , Naujokaitė Greta , Torcheboeuf Nicolas , Droz Serge , Boiko Dmitri , Dambrauskas Žilvinas , Gulbinas Antanas , Vizbaras Kristijonas
Published: September 2018

The infrared spectral region beyond 1.7 μm is of utmost interest for biomedical applications due to strong overtone and combination absorption bands in a variety of important biomolecules such as lactates, urea, glucose, albumin, etc. In this article, we report on recent progress in widely tunable swept-wavelength lasers based on type-I GaSb gain-chip technology, setting a new state-of-the-art in the 1.7 – 2.5 μm range laser sources. We provide an application example for the spectroscopic sensing of several biomolecules in a cuvette as well as an experimental demonstration of a non-invasive in-vivo sensing of human serum albumin through the skin.
Photodynamic opening of the blood-brain barrier to high weight molecules and liposomes through an optical clearing skull window
Authors: Zhang Chao , Feng Wei , Vodovozova Elena , Tretiakova Daria , Boldyrevd Ivan , Li Yusha , Kürths Jurgen , Yu Tingting , Semyachkina-Glushkovskaya Oxana , Zhu Dan
Published: September 2018

The photodynamic (PD) effect has been reported to be efficient for the opening of the blood-brain barrier (BBB), which provides a new informative platform for developing perspective strategies towards brain disease therapy and drug delivery. However, this method is usually performed via craniotomy due to high scattering of the turbid skull. In this work, we employed a newly-developed optical clearing skull window for investigating non-invasive PD-induced BBB opening to high weight molecules and 100-nm fluid-phase liposomes containing ganglioside GM1. The results demonstrated that the BBB permeability to the Evans blue albumin complex is related to laser doses. By in vivo two-photon imaging and ex vivo confocal imaging with specific markers of the BBB, we noticed PD-related extravasation of rhodamine-dextran and liposomes from the vessels into the brain parenchyma. The PD induced an increase in oxidative stress associated with mild hypoxia and changes in the expression of tight junction (CLND-5 and ZO-1) and adherens junction (VE-cadherin) proteins, which might be one of the mechanisms underlying the PD-related BBB opening for liposomes. Our experiments indicate that optical clearing skull window will be a promising tool for non-invasive PD-related BBB opening for high weight molecules and liposomes that provides a novel useful tool for brain drug delivery and treatment of brain diseases.
Detection of exudates in fundus photographs with imbalanced learning using conditional generative adversarial network
Authors: Zheng Rui , Liu Lei , Zhang Shulin , Zheng Chun , Bunyak Filiz , Xu Ronald , Li Bin , Sun Mingzhai
Published: September 2018

Diabetic retinopathy (DR) is a leading cause of blindness worldwide. However, 90% of DR caused blindness can be prevented if diagnosed and intervened early. Retinal exudates can be observed at the early stage of DR and can be used as signs for early DR diagnosis. Deep convolutional neural networks (DCNNs) have been applied for exudate detection with promising results. However, there exist two main challenges when applying the DCNN based methods for exudate detection. One is the very limited number of labeled data available from medical experts, and another is the severely imbalanced distribution of data of different classes. First, there are many more images of normal eyes than those of eyes with exudates, particularly for screening datasets. Second, the number of normal pixels (non-exudates) is much greater than the number of abnormal pixels (exudates) in images containing exudates. To tackle the small sample set problem, an ensemble convolutional neural network (MU-net) based on a U-net structure is presented in this paper. To alleviate the imbalance data problem, the conditional generative adversarial network (cGAN) is adopted to generate label-preserving minority class data specifically to implement the data augmentation. The network was trained on one dataset (e_ophtha_EX) and tested on the other three public datasets (DiaReTDB1, HEI-MED and MESSIDOR). CGAN, as a data augmentation method, significantly improves network robustness and generalization properties, achieving F1-scores of 92.79%, 92.46%, 91.27%, and 94.34%, respectively, as measured at the lesion level. While without cGAN, the corresponding F1-scores were 92.66%, 91.41%, 90.72%, and 90.58%, respectively. When measured at the image level, with cGAN we achieved the accuracy of 95.45%, 92.13%, 88.76%, and 89.58%, compared with the values achieved without cGAN of 86.36%, 87.64%, 76.33%, and 86.42%, respectively.
“Buen migrante” versus “mal migrante”: construcción nacional, gobierno de lo social y retóricas meritocráticas en las políticas de integración italianas
Authors: Sebastiani Luca
Published: September 2018

Este artículo analiza las políticas italianas de integración de inmigrantes, profundizando en los discursos sobre la identidad y los valores “italianos” versus aquellos atribuidos a las personas definidas como migrantes. La discusión empírica pone de relieve: 1) la existencia de representaciones ambivalentes, que oscilan entre un llamamiento a la participación activa en el proceso de integración y la problematización del migrante como sujeto otro, caracterizado por carencias culturales ligadas a la procedencia; 2) un discurso moral y meritocrático orientado a diferenciar constantemente entre “buenos” y “malos” migrantes. El análisis resalta la persistencia del pensamiento de Estado y argumenta que tanto las representaciones contradictorias fomentadas por dichas políticas como las lógicas de inclusión diferencial que estas generan, lejos de constituir elementos dicotómicos, se refuerzan recíprocamente. Las conclusiones apuntan a una transformación de las racionalidades acontecida no solamente en este ámbito político, sino en el conjunto del gobierno neoliberal de lo social.
La construcción del “buen donante” de semen: selección, elección, anonimato y trazabilidad
Authors: Álvarez Plaza Consuelo , Pichardo Galán José Ignacio
Published: September 2018

En el año 2018 se cumplen 40 años del nacimiento de Louise Brown, la primera persona concebida por fecundación in vitro. Lo que comenzó siendo una solución para los problemas de fertilidad en parejas heterosexuales ha abierto sus puertas al acceso de otros actores sociales y ha generado oportunidades para el desarrollo de diversos modelos familiares (padres y madres monoparentales por elección o parentalidades lesbianas y gays, entre otros). En muchos casos de reproducción asistida es necesaria la participación de donantes reproductivos: donantes de semen, donantes de óvulos, de embriones y gestantes subrogadas. Este artículo se centra en los donantes de semen: quién debe elegir al donante —el personal biomédico o los receptores y las receptoras—, el anonimato o no y la trazabilidad de las muestras de semen. Se presentarán los resultados incipientes del trabajo etnográfico realizado en España y Dinamarca con donantes y profesionales de clínicas y bancos de semen, que dan cuenta de las nuevas concepciones y relaciones que estas realidades están suponiendo para los diversos actores implicados en los procesos de reproducción asistida.
Deseos, semen y bebés. Técnicas reproductivas y comaternidades lésbicas
Authors: Falguera Ríos Mercè
Published: September 2018

En este artículo se presentan algunos ejemplos etnográficos sobre las experiencias de parejas de mujeres lesbianas que acuden a clínicas privadas para poder acceder a su proyecto de maternidad. Sus proyectos de maternidad surgen de sus deseos de ser madres a partir de la experiencia corporal de la gestación de una de ellas. El enfoque de género permitirá explorar la visión binaria y heterosexista que atraviesa los protocolos y la atención biomédica en estos casos y la forma en que las mujeres lesbianas dan significado a sus experiencias de maternidad y cómo gestionan dos identidades que tradicionalmente han sido pensadas como contradictorias: la de madre y la de lesbiana. En esta investigación se abordó la complejidad de las maternidades desde una posición feminista que contempla con otra mirada las relaciones materno-filiales y, al mismo tiempo, rechaza la “institución materna”. El artículo se basa en una investigación etnográfica en Catalunya sobre las maternidades lésbicas a partir de técnicas de reproducción asistida. Se hace un recorrido desde el momento en el que las mujeres se imaginan ser madres hasta el inicio de los tratamientos de fertilidad y la consecución de un embarazo.
Elecciones reproductivas, anonimato y parentesco: discursos e implicaciones para las "madres solteras por decisión"
Authors: Frasquet Aira Rosa María
Published: September 2018

El anonimato o no anonimato en las donaciones de gametos está siendo foco de debates en el ámbito internacional, avanzando las posiciones más favorables a su levantamiento. En el caso de España, la ley prescribe aún el anonimato. En este contexto de debates en torno anonimato/no-anonimato, este artículo analiza las estrategias reproductivas de las madres solteras por elección  —mujeres que deciden ser madres al margen del esquema de pareja y de familia hetero-biparental— atendiendo tanto al recurso a donantes conocidos y/o anónimos como a las estrategias, apropiaciones y resignificaciones del anonimato. La base empírica del artículo está constituida por entrevistas en profundidad a 27 mujeres en diferentes momentos del proceso de convertirse en madres con donante, así como en observación participante en diversos espacios de encuentro (tanto on line como presenciales) en el área de Barcelona. El trabajo sostiene que el anonimato se resignifica como una práctica de cuidado hacia los hijos/as, protegiéndoles frente a la figura del padre ausente y asegurando la autonomía del proyecto familiar. Asimismo, se analizan las lógicas androcéntricas implícitas en la consideración de estas estrategias reproductivas como individualistas, sosteniendo que se trata de reformulaciones de la estigmatización de las madres solteras en las sociedades patriarcales y, por extensión, sanciones a la autonomía reproductiva de las mujeres que eluden que la responsabilidad social de la crianza acaba —de nuevo— concentrada en la figura de la madre.
Características de las familias creadas por gestación subrogada en el Estado español
Authors: Morero Anna María
Published: September 2018

A pesar de la inexistencia de datos cuantitativos sobre gestación subrogada en el Estado español, diversos indicadores apuntan a que esta es una vía cada vez más común para acceder a la maternidad y a la paternidad. Este artículo explora las principales características de las familias españolas creadas a través de gestación subrogada en diversos países del mundo. Para ello se aportarán datos primarios obtenidos de la aplicación de la encuesta EMirrors, que tiene como finalidad profundizar en el conocimiento sobre los procesos de gestación subrogada que personas españolas, tanto en pareja como de forma individual, realizan para crear sus familias. Concretamente, los resultados aquí presentados ofrecen un perfil sociodemográfico de las madres y los padres de intención españoles, pero también muestran las motivaciones que les llevaron a elegir la gestación subrogada, así como las principales características de dichos procesos.
Vicisitudes con/en la deutsche Sprache. Un ensayo autobiográfico acerca de las igualdades y las diferencias
Authors: De Marinis Pablo
Published: September 2018

El artículo narra en clave autobiográfica mi experiencia como estudiante de doctorado inmigrante (no “viajero” ni “exiliado”) en Alemania, poniendo especial énfasis en las diversas etapas que marcaron el proceso de aprendizaje de la lengua alemana. La primera etapa que describo es aquella en la que seguí un curso universitario formal e institucionalizado de alemán como lengua extranjera. Luego, explico los complejos procesos por los cuales me convertí en un lector y en un traductor (no sólo de textos, sino de sentidos, experiencias y vivencias). Finalmente, narro las peripecias vividas en la escritura de mi tesis doctoral. Además, articulo todas aquellas experiencias con unas reflexiones más amplias acerca del significado del lenguaje y la traducción, así como acerca de la igualdad y la diferencia, en la especificidad de las ciencias sociales y más allá de ellas.
Sudacas fuera de campo. Nota del editor
Authors: Gatti Gabriel
Published: September 2018

Presentación y lanzamiento de la sección de Papeles del CEIC "Sudacas fuera de campo"
A Beautiful Politics: Theodore Roszak’s Romantic Radicalism and the Counterculture
Authors: Partridge Christopher
Published: September 2018

Ugly will not be made beautiful by the increase of ugliness. And beauty—the beauty of human souls reclaimed and illuminated—is the banner and power of our revolution. A beautiful politics. Despite the bastards. The technocracy will not be overthrown. It will be displaced—inch by inch—by alternative realities imaginatively embodied.
Interracial Homosexuality and the White Southern Phallus in Kevin Sessums’s Mississippi Sissy
Authors: Pugh Tison
Published: September 2018

In its stinging critique of the U.S. South’s rigid ideologies of race, gender, and sexuality, Kevin Sessums’s memoir Mississippi Sissy depicts interracial gay relationships as a profound subversion of the region’s conservative ethos. At the same time, this memoir succumbs to phallic posturing that imagines white and black gay masculinities within regressive and patriarchal terms, which thus ironically reinstitutes the binaries of race and desire it otherwise subverts. The intransigence of Southern codes of masculinity troubles Sessums’s otherwise progressive portrayal of queer sexuality, thereby displaying the force of regionalisms in that ostensibly universal construct, the phallus.
Claves para fomentar la creatividad y las artes en familia y escuela
Authors: Lage de la Rosa Marta
Published: September 2018

Las artes son conocimiento, descubrimiento, indagación, expresión de la emoción y de la dimensión más espiritual de las personas que es lo más valioso que ha de preservar la educación para nuestro bienestar y crecimiento. Hoy, saber desarrollar competencias creativas y artísticas es esencial para innovar, estar bien y ser felices. Como no se imparte por especialistas, en infantil y primaria cada vez hay menos conocimiento de las mismas. Descubre aquí estrategias o claves básicas para saber qué hacer y cómo en la familia y en la escuela.
Aprender pensando: metodologías artísticas para la escuela
Authors: Martínez Cano Silvia
Published: September 2018

La educación artística está cambiando la situación del aprendizaje en la escuela. Las nuevas metodologías artísticas conciben un currículo educativo que se enmarca en los procesos creativos que permiten un aprendizaje activo y significativo. La multidisciplinariedad del arte ayuda a los docentes a desarrollar metodologías que favorecen la interacción, la manipulación, la experimentación e interiorización de contenidos curriculares desde el juego y la resolución de problemas. Conecta conocimientos, relaciona y valora, es crítica con el entorno y hace propuestas para la transformación social.
Teatro y educación: las artes expresivas como pedagogía de la creatividad
Authors: Lo Monaco Mariarosaria
Published: September 2018

El arte es el medio más indicado para emplear, de manera constructiva, la energía creativa que esconden todos los niños. Maria Montessori elaboró en Italia el concepto de “experiencia”, según el cual el hacer y la acción representan la manifestación externa del pensamiento. En las últimas décadas, se han llevado a cabo numerosos estudios sobre el vínculo entre la realización de actividades artísticas y el desarrollo de las capacidades cerebrales de la persona en edad escolar, enfatizando la función del arte en sus diferentes formas (artes visuales, música, teatro, danza, etc.). El artículo hace hincapié en esta línea de investigación.
Música y arte plástico en el Orff Schulwerk. Una experiencia de integración de las artes en primaria
Authors: Santamaría Herranz Pablo , Martínez Cano Silvia
Published: September 2018

Entrevistamos a Pablo Santamaría Herranz, profesor de música y artes plásticas en el CEIP Pintor Rosales de Madrid y especialista en metodología Orff. Se trata de un método musical que involucra a los alumnos y alumnas a que compongan, toquen, canten y bailen con lo que ellos mismos van produciendo, y al mismo tiempo estimula la improvisación de nuevas ideas que les lleven a crear su propio mundo musical. El músico combina el método con otras disciplinas artísticas favoreciendo el descubrimiento y el trabajo interdisciplinar de contenidos, haciendo del tiempo en clase un tiempo gozoso de aprendizaje.
Nuestro Centro de Artes Escénicas Proyecto IM/CC de transversalidad entre etapas
Authors: Escamilla González Amparo
Published: September 2018

Nuestro deseo de avanzar en el diseño y desarrollo de proyectos IM/CC nos ha llevado a construir una estrategia que, desde primaria, invita a cooperar a las restantes etapas. Buscamos construir un proyecto transversal que nos permita seguir afianzando nuestras claves metodológicas y organizativas. Reforzaremos, así, las vías de comunicación y construcción de procesos de aprendizaje motivadores que estimulen, en diálogo, las distintas inteligencias y competencias, sus formatos de pensamiento, la iniciativa, toma de decisiones, la comunicación y expresión.
¡¡¡Bienvenidos al apasionante mundo del emprendimiento educativo!!! Una experiencia innovadora para plantar la semilla del emprendimiento educativo en los futuros profesores
Authors: Salas Labayen María Rosa
Published: September 2018

¡¡¡Bienvenidos al apasionante mundo del emprendimiento educativo!!! Con este sugestivo reto dio comienzo la asignatura de Autonomía Personal y Salud Infantil durante el curso 2017-18. En este artículo se describe la experiencia llevada a cabo en la mencionada materia con alumnos de 1.er curso de Educación Infantil y del doble grado de Educación Infantil y Educación Primaria en la Universidad Pontificia Comillas.
La educación artística: un recurso imprescindible para la Educación para la Ciudadanía Global
Authors: Maeztu Gomar Clara
Published: September 2018

El artículo trata el potencial de la educación artística como canal de reflexión, expresión y creación de conocimiento en los procesos socioeducativos. Lo hace a través del análisis de caso de dos procesos de trabajo con jóvenes; uno en España y otro en Nicaragua, en los que se utilizó el teatro social como metodología grupal para trabajar sobre temáticas relacionadas con la convivencia, cultura de paz y la prevención de la violencia de género.
San José de Calasanz
Authors: Ayala Guijarro Sch. P. Ángel
Published: September 2018

San José de Calasanz (1557-1648) abre en Roma la primera escuela popular y gratuita del mundo. Sus opciones educativas le convierten en el iniciador de un modo nuevo de ser y estar en la escuela: gratuidad, escuela graduada y diferenciada desde los primeros años, propuesta educativa de carácter integral, e identidad cristiana y eclesial identificarán a la escuela calasancia desde sus orígenes, herencia que se prolonga en la actividad de las Escuelas Pías, presentes hoy en 40 países de cuatro continentes.
Severe Hypocalcemia and Extreme Elevation of Serum Creatinkinase in a 16-Year Old Boy with Pseudohypoparathyroidism Type Ib
Authors: Kutílek Štěpán , Plášilová Ivana , Hasenöhrlová Kristýna , Černá Hana , Hanulíková Kristýna
Published: September 2018

Calcium is essential for proper muscular function and metabolism. Myopathy with high creatinkinase activity can be a rare manifestation of hypocalcemia of various origin, such as vitamin D deficiency, hypoparathyroidism, pseudohypoparathyroidism (PHP). 16-year old previously healthy boy was admitted to intensive care unit with convulsions lasting for three minutes and a transient loss of consciousness. Laboratory results revealed severe hypocalcemia (total S-Ca < 1.0 mmol/L; normal 2.2–2.6 mmol/L), hyperphosphatemia (S-P 2.8 mmol/L; normal 0.6–1.6 mmol/L). Serum creatinkinase (S-CK) activity was 32 μkat/L (normal 0.57–2.45 μkat/L). Other basic biochemical parameters including creatinine, troponin, alkaline phosphatase were within normal values. Calcemia was gradually corrected within two weeks by intravenously and orally administered calcium and by cholecalciferol. S-CK reached a maximum of 222 μkat/L on day 4 and dropped to 7.2 μkat/L on day 14. Boy had no myalgias, neither clinical signs of myopathy. Echocardiography was normal with normal myocardial contractility, without any signs of calcification. The serum level of parathyroid hormone (S-PTH) was high (12 pmol/L; normal 0.7–5.5 pmol/L), fully compatible with the diagnosis of PHP. Molecular analysis revealed pseudohypoparathyroidism type Ib (PHPIb).In conclusion, manifest tetany and even mild myopathy with very high S-CK can occur in hypocalcemic patients and usually resolves after normalization of hypocalcemia.
A Long-Term Control of Intramedullary Thoracic Spinal Cord Metastasis from Small Cell Lung Cancer
Authors: Osawa Hajime , Okauchi Shinichiro , Ohara Gen , Kagohashi Katsunori , Satoh Hiroaki
Published: September 2018

Radiotherapy with systemic corticosteroid therapy has been used to treat intramedullary spinal cord metastasis (ISCM), but recovery of function and long-term survival of these patients has been rarely observed. We report herein a small cell lung cancer (SCLC) patient with recurrent thoracic ISCM, who was successfully treated with radiotherapy and systemic corticosteroid therapy. A 70-year-old man, who was diagnosed as having SCLC seven months previously, developed thoracic ISCM. Soon after the detection of the lesion, the patient received radiotherapy with systemic corticosteroid therapy. Sensory disturbance in both extremities and neurogenic bladder and bowel dysfunction was recovered. The patient could walk after irradiation again. The patient received additional chemotherapy and survived 20 months after the diagnosis of ISCM recurrence. Prompt diagnosis and appropriate treatment for ISCM and effective chemotherapy for recurrent SCLC might be the favorable factors for such patients. Further studies will be required to define a favorable subset of patients most likely to benefit from a conventional approach.
From Ataxia to Diagnosis of Askin Tumor – a Case Report
Authors: Bašković Marko , Župančić Božidar , Žganjer Mirko , Nikolić Igor , Ježek Davor , Čizmić Lucija
Published: September 2018

Peripheral primitive neuroectodermal tumors (pPNET) are a group of extremely rare, aggressive, malignant tumors that are most often found in the thorax (Askin tumor), abdomen, pelvis, extremities and less frequently in the head and neck. The most important prognostic factor is the stage of the tumor. Significant progress both in surgery and in neoadjuvant and adjuvant chemotherapy and radiotherapy, as well as the improvement in diagnosis by cytogenetic and immunohistochemical analysis, should improve the survival rate. We report a case of a 14-year-old girl, with ataxic gait, cardiopulmonary compensated, without respiratory symptoms, who was referred to our hospital for further examination and treatment of newly discovered tumor of the left hemithorax. After a detailed radiological and laboratory investigation, next step was an extensive thoraco-neurosurgical surgery. After histopathological, cytological and molecular analysis, a diagnosis of Askin tumor was made.
Abnormal Communication between Lateral Thoracic Artery and Anterior Circumflex Humeral Artery – a Case Report
Authors: Kumar Dinesh V. , Rajprasath Ramakrisnan , Bhavani Prasad G.
Published: September 2018

Variations in the branching pattern of axillary artery are observed by many anatomists all over the world. A unique bilateral variation in the axillary artery was observed during the routine dissection of the upper limbs on an approximately 65 year old male cadaver. An abnormal communicative channel was observed between lateral thoracic artery and anterior circumflex humeral artery. It passed between the two roots of median nerve. Arterial anomalies in the upper limb are due to defective remodelling of vascular plexus of the upper limb bud during embryogenesis. Knowledge of variations in axillary artery is quintessential for surgeons, radiologists and anaesthesiologists to avoid treacherous complications during procedures.
The Merits of Integrating Accelerated Experiential Dynamic Psychotherapy and Cultural Competence Strategies in the Treatment of Relational Trauma: The Case of "Rosa"
Authors: Vigoda Gonzalez Nicole
Published: September 2018

The psychological sequelae of prolonged and repeated exposure to relational trauma can manifest into a challenging clinical picture typically known as Complex PTSD. Accelerated Experiential Dynamic Psychotherapy (AEDP) is a multimodal and integrative model particularly designed to address attachment disturbances and extreme forms of affective avoidance and dysregulation commonly seen in survivors of relational trauma. Conducting this treatment in a language that is not the patient’s native tongue may interfere with emotional processing, a key component of AEDP. The purpose of this study is twofold. First, it aims to examine the benefits of experiential and attachment-based models for the treatment of "Rosa," a bilingual woman and survivor of relational trauma, who presented to treatment with depressive and Complex PTSD-like symptom. Second, the study explores whether actively incorporating Rosa’s bilingualism and ethnic identity into the treatment enhanced her capacity for emotional processing and other related aspects of AEDP. This exploration constitutes an ideal avenue for documenting the clinical challenges one may encounter in doing psychotherapy with bilingual trauma survivors. For in this type of therapy, the affective processing of traumatic memories can be lost in translation. This requires the creation of an individualized treatment plan that can address these barriers, amplifying the emergence of relational safety and ultimately facilitating the patient’s new experience of core state (Fosha & Yeung, 2006), an integrated state of clarity, ease, and self-compassion.
Case Studies in Accelerated Experiential Dynamic Psychotherapy (AEDP):Reflections on the Case of "Rosa"
Authors: Iwakabe Shigeru
Published: September 2018

Systematic case studies can benefit understanding of the process and outcome of Accelerated Experiential Dynamic Psychotherapy (AEDP; Fosha, 2000) and other affect-focused and experiential therapies by expanding the scope of investigation from the moment-to-moment emotional change on which these therapies are particularly strong to changes that occur over and across sessions. Systematic case studies are also important because the link between in-session changes and changes in the client behavior and interpersonal relationships in daily life can be explored. In the engaging AEDP case study of "Rosa" (Vigoda Gonzales, 2018), the language switching that allowed Rosa to access painful emotions had an additional relational implication in that the therapist was able to directly connect to Rosa’s child self, which was encoded in a different language than her adult self. I suspect that this prevented Rosa and the therapist from running into difficulties due to the potential mismatch in their backgrounds. Corrective emotional experience seen in this therapy confirmed the finding by my own case study research team (Nakamura & Iwakabe, 2018b) that client therapeutic gains are most clearly reflected in new relationships rather than existing attachment relationships. My commentary concludes with some questions posed to the author relating to the issue of effective training in empathic attunement and working with strong emotions in therapy.
AEDP and Cultural Competence in Developmental Trauma Treatment
Authors: Riggs Skean Karen
Published: September 2018

This commentary discusses the therapy of a complex trauma survivor combining Accelerated Experiential Dynamic Psychotherapy (AEDP) with culturally competent strategies, particularly the use of a shared second language of origin. This combination potentiated the transformation of early affectively and bodily held memories and facilitated a successful outcome. Implications for short-term models and the training of therapists are discussed.
The effect of 6-week zinc supplement and weight training on the blood lipids of the sedentaries and athletes
Authors: Cinar Vedat , Akbulut Taner , Kilic Yakup , í–zdal Mustafa , Sarikaya Mucahit
Published: September 2018

In this study, we aimed to investigate the effect of 6 weeks of zinc supplementation and weight training on blood lipids of sedentary and athletes. Research group consists of total 40 males; 20 athletes who do regularly physical exercises and 20 sedentary volunteers. The volunteers were divided into four groups. These groups were constituted in that way: the first group is a natural sedentary group which called control group as well (S); the second group is another sedentary group which is supplied with only zinc (Z+S); the third group is training group which composing of athletes and is supplied with zinc (Z+T); the fourth group is the natural training group or athletes (T). From the beginning of the study to the end of 6-weeks of training, the participants gave blood samples before and after every application order to measure the total cholesterol, LDL cholesterol and HDL cholesterol and the levels of Triglyceride. This study identifies that the values of the total cholesterol, LDL cholesterol and Triglyceride of the groups which were supplied with zinc supplement decreased, whereas the levels of HDL cholesterol increased in these groups. Consequently, this work demonstrates that the 6-weeks zinc supplement and training can make a significant contribution to the performance by changing positively the levels of blood lipid.
MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway
Authors: Zhang Jian , Liu Wen-Li , Zhang Lu , Ge Rui , He Fang , Gao Tian-Yuan , Tian Qiong , Mu Xin , Chen Li-Hong , Chen Wei , Li Xu
Published: September 2018

MicroRNAs (miRNAs) play important roles in melanoma. Although miR-637 has been suggested to be a tumor suppressor in several cancers, its function in melanoma and the molecular mechanism behind that function remain unclear. In this study, we investigated the role of miR-637 in human melanoma and explored its relevant mechanisms. We found that the expression of miR-637 is significantly downregulated in melanoma tissues and cell lines. While overexpression of miR-637 inhibited melanoma cell proliferation and cell cycle G1-S transition, and induced apoptosis. Inhibition of miR-637 promoted cell proliferation and G1-S transition, and suppressed apoptosis. Subsequent investigation revealed that miR-637 expression was inversely correlated with P-REX2a expression in melanoma tissues. P-REX2a was determined to be a direct target of miR-637 by using a luciferase reporter assay. Overexpression of miR-637 decreased P-REX2a expression at both the mRNA and protein levels, and suppression of miR-637 increased P-REX2a expression. Importantly, silencing P-REX2a recapitulated the cellular and molecular effects seen upon miR-637 overexpression, whereas, overexpression of P-REX2a eliminated the effects of miR-637 overexpression on melanoma cells. Furthermore, both enforced expression of miR-637 or silencing of P-REX2a resulted in activation of PTEN, leading to a decline in AKT phosphorylation. Taken together, our study demonstrates that miR-637 inhibites melanoma cell proliferation by activation of AKT signaling pathway and induces apoptosis through regulation of Bcl-2/Bax expression via targeting P-REX2a. These findings suggest that miR-637 plays a crucial role in melanoma progression, and may serve as a potential novel target for melanoma therapy.
Association between BIM polymorphism and lung cancer outcomes: a meta-analysis
Authors: Li Xiao-feng , Wu Li-xin , Chen Hua-fei , Zhu You-cai , Wang Wen-xian , Xu Chun-wei , Lin Xue-ping , Xie Dong-fang , Du Kai-qi
Published: September 2018

Accumulating evidences have indicated that BIM expression largely decides the development of lung cancer and outcome of EGFR-mutant lung cancers after TKI treatments. BIM polymorphism is a 2,903-bp deletion in the second exon. To clarify the relationship between this BIM polymorphism and clinical outcomes of lung cancers, we conducted this meta-analysis and observed the survival and responses to TKIs. Sixteen cohort studies, covering 4393 WT and 916 BIM deletion patients were included. Overall, BIM deletion polymorphism was associated with significantly shorter progression-free survival (PFS) and slightly shorter overall survival (OS), compared to the WT group. Moreover, patients with BIM deletion polymorphism showed significantly inferior response to EGFR TKIs. In conclusion, our analysis confirmed that lung cancer patients harboring the BIM deletion have inferior survival and TKI responses. Examination of the novel biomarker BIM deletion in lung cancer patients, especially for the EGFR mutant cohort, could provide some prognostic utility.
Piperlongumine as anticancer agent: The story so far about killing many birds with one stone
Authors: Farooqi Ammad Ahmad , Attar Rukset , Yaylim Ilhan , Qureshi Muhammad Zahid , Todorovska Milica , Karatoprak Gökçe Åžeker , Najafi Saeideh , Sabitaliyevich Uteuliyev Yerzhan , Zhenisovna Tokmurziyeva Gulnara , De Sousa Damiào Pergentino , Lin Xiukun
Published: September 2018

Piperlongumine is a biologically and pharmacologically active constituent of the plant Piper longum. This compound is gradually gaining attention because of its ability to inhibit/prevent different cancers. Modern era of molecular oncology is incomplete without ground-breaking discoveries made in the field of cell signaling pathways. High-throughput technologies have considerably improved our understanding about wide ranging signal transduction cascades which play crucial role in cancer development and progression. It is exciting to note that piperlongumine has been shown to pleiotropically modulate different oncogenic signaling pathways. We partition this multi-component review into discrete sections and categorically summarize key findings related to excellent ability of piperlongumine to therapeutically target JAK-STAT, NF-kB and PI3K/AKT/mTOR pathways. We also set spotlight on regulation of TRAIL pathway and autophagy by piperlongumine in different cancers. On the basis of the current understanding of piperlongumine, molecular biologists and pharmacologists will develop the next generation of translational studies, which will prove to be helpful in improving the clinical outcome and getting a step closer to personalized medicine.
Genetic variation of yellow pistachio hard scale, Lepidosaphes pistaciae Archangelskaya (Hem.: Diaspididae) populations in Kerman province, Iran revealed by ISSR markers
Authors: Rouhani Mohammad , Vahedi Hassan Ali , Marefat Alireza
Published: September 2018

Yellow pistachio hard scale, Lepidosaphes pistaciae (Hem.: Coccoidea: Diaspididae) is one of the detrimental pests to pistachio trees. This pest is distributed throughout the pistachio producing regions of Iran. It is complex species, having distinct genetic variation. As genetically diversity awareness is essential for identification and management, the diaspidid samples selected from 10 infected region and used to test hypotheses about the genetic variability between and within its populations, during 2016. Inter simple sequence repeat (ISSR) molecular marker was used to assess genetic diversity. Extracted DNA of specimens amplified with nine ISSR primers, six of primers showed the best polymorphism. After observation and scoring bands patterns, data were analyzed with NTSYS ver. 2.02 and POPGENE ver. 1.31 software. Results showed that the bands are in the range between 100 and 2000 bp. The used ISSR primers generated 63 polymorphic fragments, and the average heterozygosity for each primer was 0.266 and the maximum number of bands were recorded for primer SMR7. A dendrogram based on the Unweighted Pair Group Method with Arithmetic mean (UPGMA) method placed them in three groups also, Anar and Baft populations were the most difference among populations. The dendrogram includes the group A (comprise populations collected from Baft, Bardsir, Zarand, Sirjan and Shahrbabak), group B (including populations collected from north Kerman, south Kerman, Kabootarkhan, and Rafsanjan) and group C (including populations collected from Anar). The results showed that ISSR markers technique is able to detect the genetic diversity among the yellow pistachio hard scale populations of various commercial pistachio cultivars within the pistachio orchards, in Kerman, Iran.
The influence of dimethyl sulfoxide (DMSO) on metabolic activity and morphology of melanoma cell line WM-266-4
Authors: Ferk Polonca , Dariš Barbara
Published: September 2018

Dimethyl sulphoxide (DMSO) is widely used as a solvent in biomedical research, regularly in concentrations up to 1%. Nevertheless, little is known about the effect of different DMSO concentration on WM-266-4 metastatic melanoma cells, which are often used in melanoma research. Due to resistance of melanoma cells high concentrations of cytotoxic substances soluble in DMSO are used in vitro tests. Consequently, total DMSO concentration often exceeds 1%. The aim of our study was to test the metabolic activity and morphology of WM-266-4 cells exposed to selected DMSO concentrations for different period of time. Cells were incubated in selected ethanol concentrations for comparison. MTT test was performed to determine proliferation activity of the cells and morphological analysis was carried out by phase-contrast microscopy. Our results show inhibitory effect of DMSO on WM-266-4 cells' metabolic activity. Morphology of the cells changed progressively with the time of exposure. Ethanol showed little effect on metabolic activity of the cells and no effect on cell morphology after selected period of time. According to our study, for specific in vitro tests concentrations of DMSO up to 1.5% may be appropriate for WM-266-4 cell line experiments.