bluuebunny/crossref_metadata_2025 huggingface dataset:
Assisted Reproductive Technologies Helping Infertile Couples or Using
Minor Girls in Poverty; Boon or Bane?
Authors: Kulanthaivel Shanmugaraj , Kaliberdenko Vitalii B. , Balasundaram Keerthanaa
Published: May 2023

According to WHO data, one in every four couples in developing countries is affected by
infertility, and the prevalence remains high year by year. Infertility is considered to be a globally concerned
health issue, which affects millions of people of reproductive age worldwide. Nowadays in our
modern and developing field of medicine, we have different solutions and treatments for almost each
and every disease. Treatment for infertility varies based on the cause, from simple psychological therapy
to some complicated procedures. All these procedures are regulated by World Health Organization
and their own country’s legislation. Each country has uniqueness in their legislation, but almost
all countries mainly focus on ethics, medical outcomes and health of both donor and recipients. However,
in some parts of the world, laws are sometimes over-ruled and not abided properly. One of such
recent incident took part in southern part of India (4 private hospitals in Tamilnadu, and 2 more hospitals
in Andhra Pradesh and Kerala), which made a shocking news for people all over the country. The
minor girl aged 16 years was exploited as egg (oocyte) donor. In the modern world, we are focusing
and researching more and more on female related health problems, but such incidents worry us. We
have a responsibility to prevent from such dreadful incidents in future, since respective governments
and courts proceed the case for veracity and justice. As doctors or medical professionals, we have to
follow our own medical and professional ethics. And as a citizen, all people including doctors and patients
must obey our countries own rules and regulations accordingly. Further we request government
authorities to make procedures and laws to be more strict and highly punishable when violated.
Successful Management of Uterocutaneous Fistula After Cesarean Delivery:
A Case Report
Authors: Yazdi Zahra , Mirzaie Monireh , Yadollahi Parvin , Khalajinia Zohre
Published: May 2023

Background:

We have, herein, presented a case of an uterocutaneous fistula after cesarian
delivery.

Case Presentation:

A 24-years old female, gravida 3 para 3 with 2 living children, who underwent an
emergency cesarean section about one month before the term due to preterm labor at Hamedan, was
diagnosed with uterocutaneous fistula. Her medical history included 2 previous term cesarean section
deliveries. She reported having fever and chills three weeks after the cesarian delivery. She also developed
nausea, vomiting, and epigastric pain. Abdominal examination revealed a 30×40mm, firm,
and tender mass on the right side of the cesarian section suture without any discharge. She was admitted
with metritis as a primary diagnosis at N.H.F hospital. The performed transvaginal ultrasonography
reported a hetero-echo mass with a diameter of 38×30×37mm with several echogenic foci and
cystic components in the right ovary. After that, an abdominopelvic CT scan was done, and a
30×40mm mass in the right ovary with non-homogeneous due to collection and abnormal density with
local hematoma at the site of the previous cesarian section was reported. Due to suspicion of lesion,
the surgery was performed with the diagnosis of fascia opening and right Tubo-ovarian abscess and
the infectious discharge of the right ovary. Right salpingo-oophorectomy surgery was performed. She
was admitted again with the complaint of infectious discharge from the right side of the suture and erythema
for one month. She also developed generalized abdominal pain. The patient was, thus, diagnosed
with a uterocutaneous fistula and was admitted to the center. She became a trans-abdominal
hysterectomy candidate and underwent surgery.

Conclusion:

One of the important risk factors for the fistula to be formed is an abscess. A few cases
have been reported of post-cesarean uterocutaneous fistula in the literature. Surgical treatment associated with medical therapy can be effective in women with multiple cesarian sections. Any infected dehiscence must be radically operated.
Early markers of Sepsis Cardiomyopathy in Murine Models by Echocardiography
Authors: Nirala Sanjeev , Rui Tan Xue
Published: May 2023

Background:

Strain echocardiography (SE) is a procedure for analyzing myocardial dysfunction that is known to be less dependent on preload and afterload of heart function. Unlike dimension-based parameters, like ejection fraction (EF) and fractional shortening (FS), SE measures cardiac function by tracking cardiac tissue deformation and anomalies throughout the cardiac cycle. Although SE is proven to locate myocardial ailments in various heart diseases, few studies exist regarding using SE relevant to sepsis pathophysiology.

Objective:

The study aimed to calculate the myocardial strain and strain rates, like longitudianl strain (LS), global radial strain (GRS), and global longitudinal strain (GLS), and to show these to be reduced earlier in cecal ligation and puncture (CLP) and lipopolysaccharide (LPS)-induced sepsis in coordination with an elevation of pro-inflammatory cytokines

Methodology:

Wild-type mice C57BL/6J (WT) were taken in this study and classified as CLP, LPS, and control groups. CLP surgery and LPS injection were given to induce sepsis. Endotoxemic septic shock was induced by intraperitoneal (IP) injection of LPS Escherichia coli.Echocardiography short axis views (SAX), longitudinal strain (LS), global circumferential strain (GCS), and global radial strain (GRS) were measured from the anterior and posterior positions of the septal and lateral walls of the heart. Real-time polymerase chain reaction (RT-PCR) was performed to evaluate post-CLP and LPS to analyze cardiac pro-inflammatory cytokines expressions. Inter- and intra-observer variables were tested by Bland-Altman analyses (BA). All data analysis was performed by GraphPad Prism 6 software. p<0.05 was taken as statistically significant.

Result:

After 48 hours following CLP and LPS-induced sepsis, a significant declination in both longitudinal strain and strain rate (LS and LSR) was identified in the CLP and LPS groups compared to the control group. Strain depression in sepsis was linked with the up-regulation of pro-inflammatory cytokines in RT-PCR analysis.

Conclusion:

In the present study, we found myocardial strain and strain rate parameters, like LS, GRS, and GLS, to be reduced after CLP and LPS-induced sepsis in coordination with the elevation of pro-inflammatory cytokines.
Human Umbilical Cord Mesenchymal Stem Cells Alleviate Rat Knee Osteoarthritis
via Activating Wnt/ β-catenin Signaling Pathway
Authors: Zhou Yue , Zhao Yingjie , Wu Yujiao , Chen Jingyu , Wu Huaxun , Wei Wei , Yan Shangxue
Published: May 2023

Background:

Osteoarthritis (OA) is a chronic disease characterized by joint cartilage degeneration,
destruction, and osteogenic hyperplasia. Human umbilical cord mesenchymal stem cells (hUCMSCs)
have attracted increasing research interest due to their high clonogenic, proliferative, and migratory
potential, as well as their improved secretion of relevant chondrogenic factors. This study evaluated the
therapeutic potential and underlying mechanism of hUC-MSCs in alleviating pathological symptoms of
OA.

Methods:

For the in vivo study, OA rats were established by the Hulth method to observe the therapeutic
effect of intra-articular injection of hUC-MSCs. X-ray tests, gross observations, and histological and immunohistochemical
assessments were conducted in rats. Levels of interleukin-1 beta (IL-1β), IL-6, matrix
metalloproteinase-13 (MMP-13), and tissue inhibitor matrix metalloproteinase-1 in rats’ synovial fluid
were measured using enzyme-linked immunosorbent assay kits. For the in vitro study, hUC-MSCs and
chondrocytes were cultured to explore the effect and underlying mechanisms of hUC-MSCs on OA.
Apoptosis, proliferation, and glycosaminoglycan (GAG) were measured in the chondrocytes. The relative
expression of aggrecan, COL-2, and SOX-9 mRNA was quantified by real-time polymerase chain reaction.
Expressions of Wnt/β-catenin signaling molecules were measured by Western blot.

Results:

We found that intra-articular injection of hUC-MSCs reduced the combined score, increased the
expression of collagen II, and decreased the expression of MMP-13, IL-1β, and IL-6 in rat knee joints.
Additionally, hUC-MSCs increased the content of GAGs, inhibited chondrocyte apoptosis, and promoted
chondrocyte proliferation. The expression of aggrecan, COL-2, and SOX-9 mRNA in chondrocytes was
promoted by hUC-MSCs via activation of the Wnt/β-catenin signaling pathway.

Conclusion:

Overall, this study demonstrated that hUC-MSCs induce the secretion of some cytokines via
the paracrine function to activate the Wnt/β-catenin signaling pathway to reduce the pathological condition
of OA and maintain the proper expression of cytokines and extracellular matrix proteins.
Dyslipidemia and Cardiovascular Prevention in the Elderly: A Balance
between Benefits and Risks of Statin Treatment in a Specific Population
Authors: Fiore Vincenzo , Barucca Alessandra , Barraco Sonia , Triggiani Domenico , Tragni Daniele , Piazzolla Giuseppina , Triggiani Vincenzo , Carbotta Giovanni , Lisco Giuseppe
Published: May 2023

Introduction:

Atherosclerotic Cardiovascular Diseases (CVD) are among the most relevant causes of morbidity and mortality worldwide, especially in aged people. Statins are one of the leading pharmacological interventions against atherosclerosis and are widely used to reduce the risk of occur-ring coronary artery diseases and related outcomes in both primary and secondary prevention. The management of chronic diseases is improved considerably over time, leading to an increase in life ex-pectancy despite heavier comorbidity-related burdens in the elderly.

Aims:

The paper focused on the role of statins in the management of atherosclerosis and related burdens in elderly patients.

Results:

Statins are essential in reducing the risk of CVD in secondary and primary prevention, partic-ularly in high-risk individuals. Guidelines encourage using specific algorithms with age-specific cut-offs to assess individual cardiovascular risk irrespective of baseline age, as the expansion of life expec-tancy produces favorable effects of statin treatment in those over 70.

Discussion:

Besides the estimation of baseline CV risk, a specific age-related assessment is also nec-essary before prescribing statin treatment in aged people focusing on frailty, potential pharmacological interactions due to polypharmacotherapy, cognitive impairment, and background chronic comorbidi-ties, such as diabetes mellitus. Before starting statin therapy, an accurate choice of type and dose of statins is needed as potential adverse events are more prevalent with high-dose than low-to-moderate-dose regimens and with lipophile than hydrophile statins (e.g., potential implication on intra-cerebral cholesterol metabolism).

Conclusion:

Despite possible adverse events, elderly patients should receive statins, when appropriate, to avoid the first occurrence of recurrent cardiovascular events and related burdens.
Evaluation of Wound Healing Activity of Statin Impregnated Collagen Scaffold
in Wistar Albino Rats
Authors: Murthy Talasila Gopala Krishna , Chowdary Bodepudi Sudheer
Published: May 2023

Background:

Wound healing is a dynamic process that is affected by various processes. Medications involved in wound healing can interfere with clot formation, inflammation reduction, and cell proliferation. Collagen is the natural existing compound that has the ability to enhance tissue regeneration. Various drugs used for healing have cons like inhibiting DNA, RNA, or protein synthesis, resulting in decreased fibroplasias and neovascularisation of wounds. Objective: The objective of this work is the formulation of the collagen scaffold impregnated with the Atorvastain using cow urine as solvent.

Methods:

The methodology involves the isolation of the collagen from the bones of the animals by using acetic acid. The obtained collagen was subjected to homogenization and sonification to get a fine powder. To this solvent, Atorvastatin and glycerine were added then it was dried at 60oC for 24 hrs to get the impregnated scaffold. The formulated scaffold was evaluated for wound healing activity by using the excision wound model.

Results:

The result shows that the scaffolds are good in nature and meet all the standards of the standard scaffold. The wound healing activity is assessed by using the excision wound healing model in rats. The results show the significant value of 99 % wound healing activity from the statin-impregnated scaffold. The biological parameters like total collagen, hexosamine, and uronic acid were evaluated and these observations indicated higher values of 4.024 ± 0.069, 304 ± 4.11, and 75.83 ± 1.93 compared with the plain scaffold.

Conclusion:

The optimised formulation exhibited good mechanical strength with better wound healing activity. The percent wound healing activity and antimicrobial activity observed from the collagen scaffold was found to be more significant compared with the scaffolds not containing statins.
Fractional Order Controller For Power Control in AC Islanded PV
Microgrid using Electric Vehicles
Authors: Rafia Anisha Asmy Nazir , Jayaprakash Ramprabhakar
Published: May 2023

Background:

Microgrids conquer a significant role in the evolution of distributed and
modern grids from the traditional electricity system. However, microgrids with renewable energy
sources connected to them often incur grid instability issues, due to the intermittent nature of these
sources.

Objective:

This work aims to study Microgrids with Electric vehicles as a backup energy source
and maintain the system’s frequency that can overcome this issue.

Methods:

This paper uses an autonomous control algorithm in an islanded ac microgrid to regulate
the active power depending on the irradiation and load scenarios, thereby maintaining the system
frequency and stability. The controller also keeps track of the battery's charge level, keeping it
from overcharging or over-discharging conditions. The PI (Proportional Integral) and Fractional
Order Proportional Integral (FOPI) controllers were compared, with the best controller utilized for
system simulations.

Results:

Simulations are presented with MATLAB/Simulink for an Islanded Photo Voltaic AC microgrid
system with the electric vehicle's battery connected to it as a source of backup energy. The
system's effect is exhibited under varied irradiations and load levels, and the findings demonstrate
the control algorithm's adaptability.

Conclusion:

This work attempts to discover the capability of the control technique to maintaining
the stability of an AC islanded microgrid system under diverse irradiation and load situations, thereby
maintaining the system's frequency and the State of Charge (SoC) of the battery of an electric vehicle
under specified levels.
Vehicle Detection in High Density Traffic Surveillance Data using
YOLO.v5
Authors: Mishra Sneha , Yadav Dileep Kumar
Published: May 2023

Computer vision is one of the prime domains that enable to derive meaningful and crisp
information from digital media, such as images, videos, and other visual inputs.

Background:

Detection and correctly tracking the moving objects in a video streaming is still a
challenging problem in India. Due to the high density of vehicles, it is difficult to identify the correct objects on the roads.

Methods:

In this work, we have used a YOLO.v5 (You Only Look Once) algorithm to identify the
different objects on road, such as trucks, cars, trams, and vans. YOLO.v5 is the latest algorithm in
the family of YOLO. To train the YOLO.v5, KITTY dataset was used having 11682 images having
different objects in a traffic surveillance system. After training and validating the dataset, three different models have been constructed setting various parameters. To further validate the proposed
approach, results have also been evaluated on the Indian traffic dataset DATS_2022.

Results:

All the models have been evaluated using three performance metrics, such as precision, recall, and mean average precision (MAP). The final model has attained the best performance on
KITTY dataset as 93.5% precision, 90.7% recall, and 0.67 MAP for different objects. The results
attained on the Indian traffic dataset DATS_2022 included 0.65 precision, 0.78 recall value, and
0.74 MAP for different objects.

Conclusion:

The results depict the proposed model to have improved results as compared to stateof-the-art approaches in terms of performance and also reduce the computation time and object
loss.
Interpolated Implicit Pixel-based Novel Hybrid Approach Towards Image
Steganography
Authors: Saini Ravi , Joshi Kamaldeep , Punyani Khusboo , Yadav Rajkumar , Nandal Rainu , Kumari Deepika
Published: May 2023

Background:

Steganography is the approach of camouflaging the covert object within
another cover object. This manuscript suggested a novel steganography approach to conceal the
covert data presence. The basic idea behind this is to generate an information-hiding approach that
increases the payload capacity and good PSNR value without sacrificing much distortion of the image.

Objectives:

To develop a novel data-hiding approach that increases imperceptibility, robustness, and
payload capacity.

Methods:

The Neighbour Mean Interpolation technique is used to scale up the original image to
generate Interpolated pixels of the given image. An even-odd scheme on the interpolated stego pixel
is used to camouflage the obscure code. MATLAB is used for the implementation of the new approach
and results calculation.

Results:

The Experimental analysis reveals that our suggested approach has a finer embedding capacity
for camouflaging the secret data as the original image of size (MxN) is scaled up to size (2M-
1 x2N-1) and also manages the good visuality of the cover or graven image. The proposed method is
compared with Jung and Yoo, and Selvrani's method. The result of this comparison shows that the
proposed method has finer imperceptibility than these two previously existing techniques.

Conclusion:

A novel approach towards image steganography using neighbor mean interpolation has
been proposed and implemented. A new steganography method is used for camouflaging the confidential
code into the cover object using NMI without producing any major differences in the input
image. The new approach provides better imperceptibility, robustness, and payload capacity.
Analisis Maqashid Al-Syariah Dalam Sistem Ekonomi Islam dan Pancasila
Authors: Adzkiya Ubbadul
Published: May 2023

The development of the Islamic economy in Indonesia has made the significant progress. Islamic economics has the spirit to integrate between the economy with religious theology. Indonesia has claimed itself as a country based on Pancasila and Constitution of 1945. Among Muslim economists, there are various opinions on the relationship between the state and religion that related to the position of the Islamic economy in a framework of the Indonesian State.This paper aims to strengthen the Islamic economic system in Indonesia, to strengthen Pancasila is according to maqashid al-sharia in economic terms, and a relevant alternative relationship between Islamic economy and Pancasila. The results of this study are The Islamic economy system in Indonesia is done in line with Pancasila as the basis of the State. This is based on the idea that Pancasila has included the interests of Muslims that are relevant with the objectives of sharia (maqashid al-syariah).
Analysis Disclosure of Financial Statements and Factors That Influence: Disclosures in Islamic Firm in Indonesia
Authors: Mahsun Mahsun
Published: May 2023

Financial Statement Diclausure”is a corporate report disclosure concept. One of the instruments used in company report disclosures involves corporate social environmental responsibility. Then the purpose of this study”is to reveal corporate social responsibility”such as Company Size, Profitability, Leverage, Share Ownership, and Liquidity that can influence the Financial Statement disclosure in sharia companies listed in”the Jakarta Islamic Index (JII) for the 2015-2018 period. This type of research is quantitative”research. Sampling using a proposive sampling method with sampling based on certain criteria, to obtain samples in this study were 10 companies registered in the Jakarta Islamic Index (JII) from 2015-2018. The data used is secondary data from the company's annual financial statement data from 2015-2018.”The data analysis technique uses multiple linear regression. As for the results of the study, it shows that partially”company size, profitability and leverage variables affect the disclosure of Financial Statement on companies listed in JII for the period of 2015-2018. While the share ownership and liquidity variables do not affect the disclosure of Financial Statement for companies listed in JII for the period of 2015-2018. The simultaneous variables of company size, liquidity, leverage, share ownership and liquidity affect the Financial Statement disclosure in companies listed on JII for the period 2015-2018. For the results of the test of the coefficient of determination (R square) variable company size, profitability, leverage, share ownership and liquidity can affect the Pengungkapan Laporan Keuangan disclosure in companies listed on the Jakarta Islamic Index (JII) for the 2015-2018 period of 86.3%.”
Indeks Pariwisata Halal (Implementasi Fatwa DSN MUI Tentang Pedoman Penyelenggaraan Pariwisata berdasarkan Prinsip Syariah di Kota Bukittinggi)
Authors: Wibowo Muhammad Ghafur
Published: May 2023

The halal tourism industry is increasingly developing in Indonesia, which is marked by government support and also the response of tourism industry players. In order to provide a quality standard of service for Muslim tourists, a halal tourism index has been created globally and nationally. This study tries to measure the Halal Tourism Index (HTI) with a different basis and method than the existing ones. Referring to the Fatwa of DSN MUI concerning Guidelines for Implementation of Tourism Based on Sharia Principles, this study calculates the HTI in Bukittinggi City. The results showed that the HTI in Bukittinggi City has met the good criteria, even though it does not have halal tourism regulations yet. Aspects that are still lacking in terms of managing halal tourism in Bukittinggi City are halal product certification and collaboration with Islamic financial institutions.
Islamic Development Concept: A Proposal For Betterment of Muslim Ummah in the Post-Pandemic Episode
Authors: Herman Sebastian
Published: May 2023

Islamic civilization was the pearl of the world with multidimensional aspects of achievements, especially during the Dark Age of West civilization. In stark contrast to this, the Muslim world nowadays is experiencing a marginalized society on this planet. The majority of Muslim countries are backward educationally, socially, economically, and politically. Furthermore, the world nowadays is suffering an economic crisis due to the impact of the COVID-19 pandemic.  This study tries to investigate the economic development concept from an Islamic perspective, compare it with current data on OIC member countries and provide recommendations for policymakers to stave the disaster off. The study adopts a quantitative approach in form of a literature review, discourse, and critical content analysis. It found that economic development in an Islamic perspective can be defined as a multidimensional process to improve welfare, in both material and spiritual aspects. However, In reality, OIC member countries have potentials and obstacles for growth. Strengthening the education sectors, infusion of Islamic values, support SMEs' development with ICT are some recommended policies. The main contribution of this study is to assess the current condition of Muslim Ummah represented by OIC member countries, by the development concept of Islam and deliver some policies for the betterment of the ummah.
Analisis Pengetahuan Pinjaman Online Pada Masyarakat Surakarta
Authors: Abdullah Agung
Published: May 2023

Pinjaman Online oleh masyarakat Indonesia merupakan salah satu produk dari Financial Technology yang sedang berkembang di dunia. Ketidaktahuan masyarakat mengenai ini dimanfaatkan pelaku untuk mendapatkan keuntungan yang semakin besar, dan tidak segan-segan menggunakan cara kasar dalam proses penagihan. Oleh karena itu perlu adanya penjelasan mengenai pentingnya pengetahuan masyarakat terhadap perkembangan teknologi bidang ekonomi khususnya Pinjaman Online yang dirasa sangat memudahkan masyarakat karna persyaratan dan pencairan dana yang mudah, praktis dan cepat.

Literasi atau sosialisasi mengenai masalah seperti ini dapat dilakukan secara sinergis Otoritas Jasa Keuangan selaku pemegang regulasi industry jasa keuangan. Berdasarkan fenomena tersebut penelitian ini dilakukan di lokasi yang memiliki tingkat pendidikan tinggi di Jawa Tengah dengan  tingkat ekonomi yang tinggi pula yaitu Kota Surakarta. Penelitian ini menggunakan metode kualitatif deskriptif dengan masyarakat yang berdomisili di Kota Surakarta  sebagai objek dari penelitian ini.

Hasil dalam penelitian ini diketahui bahwa masyarakat Surakarta yang didominasi oleh generasi muda telah memiliki pengetahuan tentang pinjaman online. Berdasarkan pengetahuan tersebut, masyarakat dapat memilih pinjaman online legal yang aman digunakan karena pinjaman online legal di bawah pengawasan Otoritas Jasa Keuangan (OJK) tidak seperti pinjaman online ilegal yang dapat membahayakan masyarakat.
Platform Layanan Ekonomi Berbagi: Studi Kualitas Layanan dan Kepercayaan terhadap Keberlanjutan Penggunaan dengan Religiusitas sebagai Moderasi
Authors: Amanda Syafira , Sari Nurma
Published: May 2023

This study aims to measure the effect of service quality and trust towards the continuance intention of sharing economy service platforms moderated by the religiosity variable. The object of research are the undergraduate students of Syiah Kuala University in Banda Aceh with a sample data that collects 100 respondents using the proportionate stratified random sampling method. The research was conducted partially and simultaneously. Collected data were analyzed using multiple linear regression analysis and moderated regression analysis. The results show that service quality and trust have a significant silmutaneous and partial effect on the continuance intention of sharing economy service platforms. Next, religiosity negatively moderates the relationship of trust towards the continuance intention of sharing economy service platforms in Banda Aceh City.
Partial Analysis of Mudharabah Financing on the Profitability of the Sharia Commercial Banks in Indonesia
Authors: Jahroh Siti , Suganda Asep Dadan
Published: May 2023

In order to gain profits, sharia banks as the actors who collect and distribute the fund from and for the people are trying to improve the quality and quantity of their performance, and mudharabah is one of the financing akad in sharia banks. This study aimed to determine the effect of mudharabah financing on the profitability (ROA) at sharia commercial banks (BUS) in Indonesia. The populations in this study were all registered Sharia Commercial Banks in the central bank of Indonesia (BI) with a total of 14 banks. However, from this population, 9 banks were failed to complete the data. This study used a simple linear regression analysis method, the classical assumption test method, and statistical test. The conclusion drawn from the partial testing showed a significant effect with t observe of 2.053. Since the value of t observe 2.053 > t table 2.048, it can be concluded that there was a significant effect of mudharabah financing on the Return on Assets (ROA).
The Impact of Model, Price, and Quality Factors: Variable Level of Consumer Satisfaction as a Measure in Buying Woven Sarong Products
Authors: Devita Lusy Deasyana Rahma
Published: May 2023

The purpose of this study was to investigate the consumer behavior will determine the achievement of company objectives. Consumers will consider a variety of factors related to production. The study was conducted on. The population under study is consumers who've come to buy Gloves loom. The sample used 80 respondents. The variables used in the study include the Model, Price, and Quality Sampling method using purposive sampling with descriptive and statistical analysis techniques including multiple regression analysis. Hypothesis testing with simultaneous test or F-test hypothesis testing with a partial test or t-test and analysis of multiple determination coefficient. The test results simultaneously show variable models, prices, and quality jointly significant effect on customer satisfaction at with Fhitung 186.747. using partial test showed variable model (X1) of 0.3220, the price (X2) is -151, and the quality (X3) of 0.6540 does not have a significant influence on consumer satisfaction. And variable quality (X3) was the dominant effect on customer satisfaction in buying products sarong.
Ab-Chicken Sharia Partnership Business Strategy: In the Face of a Global Economic Recession
Authors: Kurniawan Heru , Aziz Abdul
Published: May 2023

The threat of a global recession is the thing that entrepreneurs are most aware of, including AB Chicken. In this study, the authors used a qualitative approach with descriptive analysis methods, and data collection techniques were obtained from direct observations in the field. The results of this study AB Chicken as a food and beverage business made three strategies in dealing with the global recession, namely implementing a sharia business concept with a da'wah-based marketing approach, building religious and humanitarian images, partnerships with a family concept, increasing skilled and religious human resources and expanding urban markets with services delivery (cloud kitchen). The novelty of this research is the propaganda media as a marketing strategy for AB Chicken through Buya Yahya's preaching with the motto "delicious chicken, delicious blessings".
Implementation of the MSME Micro Financing Strategy Through a Murabahah Agreement at BSI KCP Bangkalan Trunojoyo
Authors: Amalna Fika , Ardyansyah Farid
Published: May 2023

This study analyzes murabahah financing to help ease the burden on customers and promote MSME businesses. In general, murabahah financing is given to customers for short-term financing to meet the needs of an item needed by the community. This research method uses a qualitative approach, namely research that describes events and all matters related to circumstances based on facts found in the field. This study uses primary and secondary data with data collection methods through observation and interviews. The findings from this study indicate that the strategy implemented by BSI KCP Trunojoyo Bangkalan can solve the problem, namely through Rescheduling, Reconditioning, and Restructuring. Management assistance, Novation (AYDA), subrogation, inclusion, liquidation under the hands of HT/FEO execution auctions, auction via court, execution auction via Basyarnas, execution auction via court.
Implementation of Sharia Marketing Strategy as a Solution to Increase Linkaja Syariah Consumer Loyalty
Authors: Firdausi Firna Nahwa , Ardyansyah Farid
Published: May 2023

 The purpose of this research is to find out the sharia marketing strategy as a solution to increase LinkAja Syariah consumer loyalty. The method used is a qualitative approach with descriptive analysis. Source of data obtained from primary data through interviews. The findings of this study indicate that the sharia marketing strategy implemented by LinkAja is a strategy that can increase the loyalty of LinkAja Syariah consumers. Promos and events are one of the sharia marketing strategies that are organized by providing various features in one application that make it easy and very practical for users to carry out all their transaction needs. The LinkAja Syariah strategy is carried out as an implementation to the community of the importance of sharia-based transaction education. The sharia marketing strategy is a form of activity that aims to meet customer needs through good behavior in providing halal products and services following a mutual agreement to achieve material and spiritual balance.
Factors Affecting Digital Tool Use in Client Interaction According to Mental Health Professionals: Interview Study
Authors: Lukka Lauri , Karhulahti Veli-Matti , Palva J Matias
Published: May 2023

Background

Digital tools and interventions are being increasingly developed in response to the growing mental health crisis, and mental health professionals (MHPs) considerably influence their adoption in client practice. However, how MHPs use digital tools in client interaction is yet to be sufficiently understood, which poses challenges to their design, development, and implementation.

Objective

This study aimed to create a contextual understanding of how MHPs use different digital tools in clinical client practice and what characterizes the use across tools.

Methods

A total of 19 Finnish MHPs participated in semistructured interviews, and the data were transcribed, coded, and inductively analyzed.

Results

We found that MHP digital tool use was characterized by 3 distinct functions: communication, diagnosis and evaluation, and facilitating therapeutic change. The functions were addressed using analog tools, digitized tools that mimic their analog counterparts, and digital tools that use the possibilities native to digital. The MHP-client communication included various media alongside face-to-face meetings, the MHPs increasingly used digitized tools in client evaluation, and the MHPs actively used digitized materials to facilitate therapeutic change. MHP tool use was generally characterized by adaptability—it was negotiated in client interactions. However, there was considerable variance in the breadth of MHPs’ digital toolbox. The existing clinical practices emphasized MHP-client interaction and invited incremental rather than radical developments, which challenged the achievement of the scalability benefits expected from digital tools.

Conclusions

MHPs use digitized and digital tools in client practice. Our results contribute to the user-centered research, development, and implementation of new digital solutions in mental health care by classifying them according to their function and medium and describing how MHPs use and do not use them.
Evaluation of the state of colonic microflora in patients with non-alcoholic fatty liver disease with immune response to SARS-CoV-2
Authors: Stepanov Yu.M. , Didenko V.I. , Klenina I.A. , Tatarchuk O.M. , Vishnarevska N.S. , Petishko O.P.
Published: May 2023

Background. The prevalence of non-alcoholic fatty liver disease (NAFLD) is currently increasing worldwide and is a serious problem that causes interest in its study, especially in patients with an immune response to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). In recent years, studies have been investigating the influence of microflora on the development and progression of NAFLD. The purpose of the study was to determine the level of dysbiotic disorders of the colonic microbiocenosis in patients with NAFLD with an immune response to SARS-CoV-2. Materials and methods. We examined 34 patients with NAFLD who were found to have IgG to SARS-CoV-2. All examined patients were divided into two groups: group I consisted of 17 patients with no history of SARS-CoV-2 according to the polymerase chain reaction (PCR) data; group II— 17 patients with a history of SARS-CoV-2 by PCR. The control group consisted of 10 practically healthy individuals. Chromatographic determination of the content of short-chain fatty acids, species and quantitative composition of the colonic microflora was performed. Results. The microbiological studies revealed changes in the qualitative and quantitative composition of the colonic microflora in 88.2% of patients with NAFLD, with a predominance of dysbiosis II in 41.2% of patients in group I and dysbiosis I in 70.6% of patients in group II. These changes were due to a decrease in the number of bifidobacteria and lactobacilli, an increase in the concentration of opportunistic pathogens, fungi of the genus Candida spp. The intestinal microbiome of patients with NAFLD who had SARS-CoV-2 showed impaired biosynthesis of short-chain fatty acids in the coprofiltrate, which was manifested by an increase in the median acetic and propionic acids and a decrease in the median butyric acid in patients of group I. The median anaerobic index had a statistically significant decrease in patients of group I by 1.5 times (p<0.05) and a tendency to a decrease in patients of group II. Significant intergroup differences were found for anaerobic index, its median was 1.4 times higher in group II (p<0.05) compared with group I. Conclusions. A decrease in the level of normoflora representatives, an increase in opportunistic pathogens, a tendency to a decrease in the concentration of butyric acid, an increase in acetic and propionic acids in the feces were found in patients with NAFLD who had SARS-CoV-2.
GREEN METHOD FOR ACETAMINOPHEN AND IBUPROFEN SIMULTANEOUS ASSAY IN THE COMBINATION TABLET USING FTIR
Authors: Nugrahani Ilma , Khalida Farah Nur
Published: May 2023

Objective: The purpose of this study was to develop a green method for assay the tablet consists of a combination of acetaminophen (ACT)-ibuprofen (IBU). FTIR (Fourier Transform Infrared Spectroscopy), which is commonly used for qualitative analysis, was developed to measure the tablet contents, directly and quantitatively.Methods: Standard for ACT and IBU was respectively mixed with KBr crystal in varied and measured using FTIR. The transmission spectrum yielded later was converted into its absorbance-derivatized forms which then a calibration curve was composed using the data. Once validated, the analytical method was conducted on samples of the branded ACT-IBU combination tablet.Results: ACT had a specific wavenumber of a group N-H stretch, meanwhile IBU was represented by the C = O spectrum. These peaks then used for quantitative calculation basis levels respectively. The limits of detection and quantitation of ACT consecutively were % w/w and Â w/w and IBU were % w/w and Â w/w. Next; the method was carried out successfully to evaluate the content of sample tablet from the market.Conclusion: The analytical method of ACT-IBU was proven applicable and suitable for the quantitative purpose. The method shows meet with the expectation such as simple and easy to perform and reduce the use of solvents.
DEVELOPMENT AND VALIDATION OF A SIMPLE UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CIPROFLOXACIN HCL PRESENT IN TASTE MASKED DRUG RESIN COMPLEX
Authors: Rajendra Prasad Ayya , Ratna Jayanthi Vijaya
Published: May 2023

Objective: The objective of this study was to develop and validate a novel, specific, precise and simple UV-spectrophotometric method for the estimation of ciprofloxacin HCl present in taste-masked drug-resin complex.Methods: UV-spectrophotometric determination was performed with ELICO SL 1500 UV-Vis spectrophotometer using 0.1 N HCl as a medium. The spectrum of the standard solution was run from 200-400 nm range for the determination of absorption maximum (Î» max). Î» max of ciprofloxacin HCl was found at 276 nm. The absorbance of standard solutions of 1, 2, 3, 4, 5 and 6 Âµg/ml of drug solution was measured at an absorption maximum at 276 nm against the blank. Then a graph was plotted by taking concentration on X-axis and absorbance on Y-axis which gave a straight line. Validation parameters such as linearity and range, selectivity and specificity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision and robustness were evaluated as per ICH guidelines.Results: Linearity for the UV-spectrophotometric method was noted over a concentration range of 1-6 Âµg/ml with a correlation coefficient of 0.9995. The limit of detection (LOD) and limit of quantification (LOQ) for ciprofloxacin HCl was found at 0.46 Î¼g/ml and 1.38 Î¼g/ml respectively. Accuracy was in between 98.89 and 99.27%. % RSD for repeatability, intraday precision and interday precision were found to be 1.271, in between 0.351 and 0.659 and in between 1.067 and 1.769 respectively. The proposed UV spectrophotometric method is found to be robust.Conclusion: The proposed UV-spectrophotometric method was validated according to the ICH guidelines and results and statistical parameters demonstrated that the developed method is sensitive, precise, reliable and simple for the estimation of ciprofloxacin HCl present in taste-masked drug-resin complex.
ARRACACIA XANTHORRHIZA ACETYLATED STARCH: A NEW EXCIPIENT FOR CONTROLLED DRUG DELIVERY
Authors: Carrascal Juan J , Matiz GermÃn , Baena Yolima
Published: May 2023

Objective: Chemically modify by acetylation, Arracacia xanthorrhiza starch, and to physicochemically and pharmacotechnically characterize it, thereby evaluating its potential as a pharmaceutical excipient, in comparison with the native starch of Arracacia xanthorrhiza.Methods: The chemical modification was performed through acetylation with acetic anhydride (AA) on different levels, determining following starch's characteristics: degree of substitution (DS), size and form of particles, its degree of crystallinity through X-ray powder diffraction (XRPD), gelatinization temperature (Tg) through differential scanning calorimetry (DSC), swelling power (SP) and sorption isotherms by means of Enslin method, and its application as excipient in tablet production, using diclofenac as model drug.Results: On the third level of substitution, the morphology of modified-starch particles presented changes on their surface and all modified starches increased their particle average sizes, in comparison to native starch. Starch crystallinity was not altered by acetylation, and the DS increased as more AA was added to the reaction. This modification caused a decrease of Tg by approx. 9.45 Â°C for A. xanthorrhiza starch modified to level III, in comparison to native starch. SP and water uptake capacity increased with starch modification, being greater to higher DS. Dissolution studies conducted on tablets showed that diclofenac delivery occurs practically immediately when using native starch, while those made of acetylated starch were close-fitting with Korsmeyer-Peppas model, with a release mechanism that suggests an anomalous, non-Fickian transport behaviour, related to a mechanism governed by swelling and diffusion.Conclusion: The results suggest A. xanthorrhiza acetylated starches, as promising materials for the development of controlled-delivery matrix systems.
BILAYER TABLET OF TRAMADOL AND GABAPENTIN FOR COMBINATION PHARMACOTHERAPY OF NEUROPATHIC PAIN: DEVELOPMENT AND CHARACTERIZATION
Authors: Kamble Santosh , Poul Bhagwat , Udapurkar Prachi
Published: May 2023

Objective: Experiments were performed to design, develop and characterize bilayer buoyant tablets having tramadol (TH), immediate release (IR) layer and gabapentin (GBP), sustained release (SR) layer.Methods: Natural hydrophilic polysaccharide disintegrants were modified by sequential processes to obtain treated xanthan gum (TXG) and treated gellan gum (TGG), utilized for IR layer whereas carbopol and sodium carboxymethylcellulose, as sustaining polymers for SR layer and gas producing substance sodium bicarbonate which librates carbon dioxide for adequate buoyancy, was used in formulated bilayer tablet. A full two-level factorial experimental design was used for sustaining GBP release from buoyant SR layer.Results: Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) studies conducted, explain overall drug and excipients compatibility. More than 90% of tramadol was released from IR layer within 30 min. Diffusion exponents (0.36-0.59) and T50% (2.4-4.4h) were determined for all SR tablet formulations. Optimised (S7) formulation exhibited 95.77% GBP released over 12h.Conclusion: Developed tablet can provide excellent therapeutic result by the sequential immediate release of TH and sustained release of GBP for effective combination pharmacotherapy of neuropathic pain with once a day administration.
THE OPTIMIZATION OF ELUTING CONDITION OF SOLID PHASE EXTRACTION METHOD FOR ï¡-MANGOSTIN PURIFICATION IN MANGOSTEEN PERICARP EXTRACT
Authors: Saputri Febrina Amelia , Mayangsari Annisa , Muchtaridi Muchtaridi
Published: May 2023

Objective: To obtain the optimum condition of eluent selection for purification of Î±-mangostin in mangosteen pericarp extract with solid phase extraction (SPE) method.Methods: The analysis was conducted by SPE cartridge octadecylsilane (ODS)-5, solvents used were methanol for conditioning, aqua bidestilated for washing and three different eluents for eluting: methanol, ethanol and ethyl acetate.Results: Recovery value for each eluent were 32.4741% for methanol, 46.6130% for ethanol and 33.6383% for ethyl acetate. Comparison of alpha-mangostin level in the mangosteen pericarp extract for each eluent i.e. 14.4578% for methanol, 10.0598% for ethanol, and 14.2898 % for ethyl acetate while compared to the extract without SPE was 21.7934%.Conclusion: Ethanol had the highest recovery value, compared to methanol and ethyl acetate.
SIMPLE DESIGN OF MINIATURIZED CABINET FOR COMPOUNDING VITAMIN C EFFERVESCENT TABLET IN LABORATORY SCALE
Authors: Kusuma Sri Agung Fitri , Abdassah Marline , Aritrixso Arryo
Published: May 2023

Objective: The aim of this study was to design miniaturized cabinet that needs the tight requirements in formulating the ingredients of the effervescent tablets to minimize the relative humidity value in order to prevent the initial effervescent reaction.Methods: The compounding workspace was created by designing cabinet arranged with special equipment so that the humidity and temperature of the mixing chamber could be monitored. The conditioning of the workspace was carried out using a variety of methods ie lights, active silica gel and a combination of both during certain observation times. In this study, all of the components in the effervescent tablet formula were mixed using two steps of the wet granulation method. The evaluation of effervescent tablets included: the appearance of the tablet, diameter, tablet thickness, weight uniformity, hardness, friability, tablet disintegration time, pH of the solution, and hedonic test.Results: The results of moisture control optimization indicated that the most rapid method of lowering moisture was using a combination of active light and silica gel. After 100 min, this method could decreased the relative humidity (RH) by 0.415% per min. Based on the evaluation results, all formulas achieved the requirements of good effervescent tablets.Conclusion: In this research, the design of compounding cabinets with dimensions of 60x40x59.5 cm was proven to produce effervescent tablets that fulfill the requirements.