bluuebunny/crossref_metadata_2025 huggingface dataset:
PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer
Authors: wang xingang , ZHENG YAN , WANG YU
Published: May 2021

Background and AimsPseudopodium-enriched atypical kinase 1 (PEAK1) has reported to be upregulated in human malignancies and related with poor prognosis. Enhanced PEAK1 expression facilitates tumor cell survival, invasion, metastasis and chemoresistance. However, the role of PEAK1 in breast cancer is not clear. Here, we investigated the PEAK1 expression in breast cancer and analyzed its relation with clinicopathological status and chemotherapy resistance to the neoadjuvant chemotherapy (NAC). We also investigated the role of PEAK1 on breast cancer cells in vitro and in vivo. MethodsImmunohistochemistry (IHC) was performed in 112 surgical resected breast cancer tissues. The associations between clinicopathological status, multi-drug resistance and PEAK1 expression were determined. Effect of PEAK1 overexpression or down-expression on proliferation, colony formation, invasion, migration, metastasis and Doxorubicin sensitivity in the MCF-7 cells in vitro and in vivo was detected. ResultsPEAK1 was overexpressed in breast cancer tissues and NAC -resistant breast cancer tissues. High PEAK1 expression was related with tumor size, high tumor grade, T stage, LN metastasis, recurrence, Ki-67 expression, Her-2 expression and multi-drug resistance. Targeting PEAK1 inhibited cell growth, invasion, metastasis and reversed chemoresistance to Doxorubicin in breast cancer cells in vitro and in vivo. ConclusionHigh PEAK1 expression was associated with invasion, metastasis and chemoresistance of breast cancers. Furthermore, targeting PEAK1 could inhibit cell growth and metastasis, and reverse chemoresistance in breast cancer cells, which provides an effective treatment strategies for breast cancer.
Awareness and Knowledge of Hiv Transmission and Prevention Among Military Personnel In Abuja, Nigeria
Authors: Adekunle Olajide Ayodele , Adeyemi David A.
Published: May 2021

Background

The personnel of the Nigerian military indulge in high-risk sexual behaviors and hence, they pose as a potential core transmission group of HIV to the larger population. Despite the initiation and implementation of various strategies of improving adequate knowledge of HIV transmission and prevention, there is still high proportion of military personnel without appropriate knowledge of preventing HIV transmission. The aim of this study is to assess level of knowledge of HIV prevention and transmission and identify factors influencing transmission of HIV among military personnel in Nigeria.
Methods

A cross-sectional study design, using a semi-structured questionnaire was used to collect data on respondents’ socio-demographic characteristics, utilization of male condom. Data was analyzed using descriptive statistics, Chi-square tests and logistic regression at p < 0.05.
Results

While 98.5% of respondent have ever heard of HIV, 80.3% claimed to have seen or heard information about HIV, with media (85.9%) been the major source of this information. Out of the 391 respondents, 174 (44.5%) and 217 (55.5%) military personnel had inadequate and adequate knowledge of HIV transmission respectively while 80.8% and 19.2% of these respondents had inadequate and adequate knowledge of HIV prevention, respectively.
Conclusions

While there was no significant difference in the proportion of those military men that had adequate and inadequate knowledge of HIV transmission, there was a clear and significant difference in the proportion of military men with adequate and inadequate prevention knowledge. Age, education, marital status, and service arm are predictive factors that could influence knowledge of HIV transmission and prevention.
Curcumin Ameliorates Chronic Mild Stress-Induced Depressive-Like Behavior via HMGB1/TLR4/NF-κB Signaling Pathway
Authors: Miao Li , Huang Fei , Jiang Wei , Sun Ying-ying , Chen Yong-jin , Zhang Min
Published: May 2021

BackgroundDepression, one of the most frequently-occurring psychiatric disorders worldwide, is a significant inflammatory disorder. The polyphenol curcumin (Cur), which is extracted from Curcuma longa, has marked anti-inflammatory and anti‑oxidative effects against inflammatory diseases. However, whether Cur has antidepressant effects and the possible mechanisms, are unclear. The present study aimed to assess Cur’s beneficial effects on depressive-like behaviors using a chronic unpredictable mild stress (CUMS) model and its possible molecular mechanisms. MethodsWe performed CUMS treated Sprague Dawley (SD) rats as a model of depression. Behavioral observations were performed by sucrose preference test (SPT), force swimming test (FST) and tail suspension test (TST). Hippocampal expression of oxidative stress markers and inflammatory cytokines were measured with ELISA. Hippocampal expression of high-mobility group box 1 (HMGB1), IL-1β, TNF-α and IL-6 were determined with quantitative PCR analyses and immunofluorescent staining. Hippocampal Toll-like receptor 4 (TLR4) and NF-κB activation were examined with Western blotting analysis.ResultsRats subjected to CUMS demonstrated marked depressive-like behavior (decreased locomotor activity and sucrose intake, and prolonged immobility). Their levels of oxidative stress and inflammatory cytokines increased significantly, and their levels of phosphorylated nuclear factor kappa-B (NF-κB), toll-like receptor 4 (TLR4), and HMGB1, also increased in the hippocampus. The changes were ameliorated significantly by treatment with Cur (50, 100 mg/kg) to varying degrees.Conclusion This study demonstrated that Cur has a potent antidepressant effect via the HMGB1/TLR4/NF-κB pathway, suggesting that Cur might be a promising therapeutic drug for depression.
Automated Vessel Segmentation in CT and CTA scans of the Lung Via Deep Neural Networks
Authors: tan wenjun , zhou luyu , li xiaoshuo , yang xiaoyu , chen yufei , yang jinzhu
Published: May 2021

Background: The distribution of pulmonary vessels in computed tomography images is important for diagnosing disease, formulating surgical plans and pulmonary research. However, there are many challenges of pulmonary vascular segmentation due to its characteristics of narrow and long pipes, discrete distribution and tree-like structure. With the development of deep learning and medical image processing, an automatic, accurate and fast segmentation algorithm of pulmonary blood vessels becomes possible. Methods: Based on the International Symposium on Image Computing and Digital Medicine 2020 challenge pulmonary vascular segmentation task, this paper objectively evaluates the performance of 12 different algorithms in chest computed tomography and computed tomography angiography. First, we present the annotated reference dataset including computed tomography and computed tomography angiography. Second, by analyzing the advantages and disadvantages of each team’s algorithm from 12 different institution, the reasons for some defects and improvements are summarized. Finally, we discuss the ways and methods to improve the results. Results: These methods were compared with the ground truth by the numerical results and the intuitive results from computed tomography and computed tomography angiography images. Most methods do an admirable job in pulmonary vascular extraction, with dice coefficients ranging from 0.70 to 0.85, and the dice coefficient for the top three methods are about 0.80. Conclusions: These results show that the methods which consider spatial information, fuse multi-scale feature map, or have an excellent post-processing are significant for further improving the accuracy of pulmonary vascular segmentation. Keywords: segmentation; pulmonary; vessel; U-Net; network; CT images; CTA
Amyand’s Hernia Complicated With Acute Appendicitis in a Severe Morbidity Obesity Patient
Authors: Guo Yulin , Jiang Hua , Liu Wenqing , Liu Dongbin , Li Fei
Published: May 2021

INTRODUCTION: An Amyand’s hernia is a heterogeneous clinical condition defined by the presence of the vermiform appendix within an inguinal hernia sac, which may or may not contain other abdominal contents or pathologic inflammatory changes. Herein we present an exceptionally rare case of an Amyand’s hernia containing a suppurative appendix and omentum on a morbidity obesity patient , in order to improve our understanding of this disease, avoid misdiagnosis and share experience in the treatment. PRESENTATION OF CASE: A 46-year-old morbidity obesity male presented to our Emergency Department complained an acute onset abdominal pain near the right groin and the McBurney point with nausea and fever. The patient was initially diagnosed as acute appendicitis according to the laboratory tests and the clinical presentation. However, after a right groin hernia contained an inflamed appendix showed by the computed tomography scan, the final diagnosis of Amyand’s hernia was supported. Surgical treatment was then performed, and a right groin hernia was found to contain a suppurative appendix and omentum, intraoperatively. An appendectomy was performed, but the hernia was not repaired simultaneously considering the morbidity risks and surgically technical difficulty brought with the severe morbidity obesity. CONCLUSION: With an estimated incidence of only 1%, Amyand’s hernias are rare emergency case, lacking a clear evidence-based management scheme. Moreover, they can contain a diverse range of pathologic features and presentations that can complicate diagnosis and treatment. There is a paucity of reports describing the management of an Amyand’s hernia with appendicitis on morbidity obesity patients. In our case, we shared our surgical experience and the management of Amyand’s hernia on morbidity obesity patient should be tailored to individual’s condition.
Access to health insurance in Zimbabwe and associated factors: Insights from data from the Zimbabwe Demographic Health Survey, 2015
Authors: Musuka Godfrey Nyangadzayi , Dzinamarira Tafadzwa , Cuadros Diego F , Chingombe Innocent , Murewanhema Grant , Herrera Helena , Mapingure Munyaradzi
Published: May 2021

Objective: To determine factors associated with access to health insurance among adults in Zimbabwe. We used statistical analysis to determine the association between various variables and access to health insurance using the Zimbabwe Demographic and Health Survey, 2015-16 data. Results: Overall, only 11% of 7397 females and 12% of 7420 males included in the analysis had access to health insurance. Age, educational level, marital status, religion, area of residence and wealth quintile were associated with access to health insurance for both females and males. For females, HIV status was associated with access to health insurance. Although not statistically significant, a smaller proportion of HIV positive males (10%) had access to a medical insurance compared to their HIV negative counterparts (12%), p=0.189. Our study showed that geospatial distribution of individuals with access to health insurance in Zimbabwe is concentrated around urban areas. Since the bulk of Zimbabweans do not have access to health insurance and mainly use the public health sector for services, there isa need for the Ministry of Health to enhance its investment in these facilities so that the bulk of the population can also get quality healthcare.
Productivity losses due to diabetes in urban and rural China
Authors: Hao Hongying , Xu Lizheng , Leng Anli , Sun Jingjie , Stephen Nicholas , Wang Jian
Published: May 2021

Objective: To provide the first estimates of the cost of productivity losses attributed to diabetes age 20-69 years old in urban and rural areas of China. Methods: Construct through life table modelling, expectancy life of diabetes sufferers, including the years of potential life lost and working years of life lost. Using the human capital approach, we measured the productivity losses attributed to absenteeism, presenteeism, labor force dropout and premature deaths due to diabetes of the population aged 20-69 years in urban and rural areas in China. Results: In 2017, we estimated that there were 100.46 million diabetes lost hours, with the total cost of productivity losses US$613.60 billion, comprising US$326.40 billion from labor force dropout, US$186.34 billion from premature death, US$97.71 billion from absenteeism, and US$27.04 billion from presenteeism. Productivity loss was greater in urban (US$490.79 billion) than rural areas (US$122.81 billion), with urban presenteeism (US$2.54 billion) greater than rural presenteeism (US$608.55 million); urban absenteeism (US$79.10 billion) greater than rural absenteeism (US$18.61 billion); urban labour force dropout (US$261.24 billion) greater than rural labour force dropout (US$65.15 billion) and urban premature death (US$147.90 billion) greater than rural premature death (US$38.44 billion). Conclusions: Diabetes had a large and significant negatively impact on productivity in urban and rural in China, with a significant gap in the level of diabetes management in urban compared to rural regions. Productivity loss was significantly higher in urban than rural regions. Further investment is required in the prevention, diagnosis and control of diabetes in under-resourced health services in rural locations and also in urban areas, where most diabetes cases reside. Specifically, targeted and effective diabetes prevention and management actions are urgently required.
On Low-Dimensional Complex ω-Lie Superalgebras
Authors: Zhou Jia , Chen Liangyun
Published: May 2021

Let (g, [−, −], ω) be a finite-dimensional complex ω-Lie superalgebra. In this paper, we introduce the notions of derivation superalgebra Der(g) and the automorphism group Aut(g) of (g, [−, −], ω). We study Derω (g) and Autω (g), which are superalgebra of Der(g) and subgroup of Aut(g), respectively. For any 3-dimensional or 4-dimensional complex ω-Lie superalgebra g, we explicitly calculate Der(g) and Aut(g), and obtain Jordan standard forms of elements in the two sets. We also study representation theory of ω-Lie superalgebras and give a conclusion that all nontrivial non-ω-Lie 3-dimensional and 4-dimensional ω-Lie superalgebras are multiplicative, as well as we show that any irreducible respresentation of the 4-dimensional ω-Lie superalgebra P2,k(k 6= 0, −1) is 1-dimensional.
Nomogram for Predicting Preoperative Regional Lymph Nodes Metastasis in Patients with Metaplastic Breast Cancer: A SEER Population-Based Study
Authors: Zhang Mi , Wang Biyuan , Liu Na , Wang Hui , Zhang Juan , Wu Lei , Zhao Andi , Wang Le , Zhao Xiaoai , Yang Jin
Published: May 2021

Background: Metaplastic breast cancer (MBC) is a rare subtype of breast cancer, and generally associated with poor outcomes. Lymph nodes metastasis (LNM) is confirmed as a critical independent prognostic factor and determine the optimal treatment strategies in MBC patients. We aimed to develop and validate a nomogram to predict the possibility of preoperative regional LNM in MBC patients.Methods: MBC patients diagnosed between 1990 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database were included and stochastically divided into a training set and validation set at a ratio of 7:3. The risk variables of regional LNM in the training set were determined by univariate and multivariate logistic regression analyses. And then we integrated those risk factors to construct the nomogram. The prediction nomogram was further verified in the verification set. The discrimination, calibration and clinical utility of the nomogram were evaluated by the area under the receiver operating characteristic (ROC) curve (AUC), calibration plots and decision curve analysis (DCA), respectively.Results: A total of 2205 female MBC patients were included in the study. Among the 2205 patients, 24.8% (546/2205) had positive regional lymph nodes. The nomogram for predicting the risk of regional LNM contained predictors of grade, estrogen receptor (ER) status and tumor size, with AUC of 0.683 (95% confidence interval (CI): 0.653-0.713) and 0.667 (95% CI: 0.621-0.712) in the training and validation sets, respectively. Calibration plots showed perfect agreement between actual and predicted regional LNM risks. At the same time, DCA of the nomogram demonstrated good clinical utilities.Conclusions: The nomogram established in this study showed excellent prediction ability, and could be used to preoperatively estimate the regional LNM risk in MBC.
Sweeping quantum annealing algorithm for constrained optimization problems
Authors: Yan Zheng , Zhou Zheng , Wang Yancheng , Meng ZiYang , Zhang Xue-Feng
Published: May 2021

As a typical quantum computing algorithm, quantum annealing is widely used in the optimization of glass-like problems to find the best solution. However, the optimization problems in constrained complex systems usually involve topological structures, and the performance of the quantum annealing algorithm is still largely unknown. Here, we take an Ising system as a typical example with local constraints accompanied by intrinsic topological properties that can be implemented on quantum computing platforms such as the D-wave machine, and study the effectiveness of the quantum annealing algorithm in its optimization and compare it with that of the thermal annealing. We find that although conventional quantum annealing is difficult for the optimization of constrained topological problems, a generalized algorithm --- the sweeping quantum annealing method --- can be designed and solve the problem with better efficiency than both conventional quantum and thermal annealing algorithms. The sweeping quantum annealing algorithm, therefore, opens up a promising avenue for quantum computing of constrained problems and can be readily employed on the optimizations in quantum material design, engineering, and even social sciences.
Assessing Preoperative Hope and Expectations Related to Functional Neurosurgery: A New Questionnaire
Authors: Radomska Michalina , Santos Joao Flores Alves dos , Weber Kerstin , Baertschi Marc , Burkhard Pierre R. , Herrmann François , Belayachi Sanaâ , Favez Nicolas , Canuto Alessandra
Published: May 2021

Background: Despite successful functional neurosurgery, patients suffering from epilepsy or Parkinson’s disease may experience postoperative psychological distress and social maladjustments. Difficulties in coping with postoperative changes, even positive ones, have shown to be related to patients’ presurgery cognitive representations (i.e., expectations, hope, abstract vs. concrete representations). The aim of this study was to develop an instrument assessing various key features of surgery outcomes’ representations, namely the Preoperative Hope and Expectations Questionnaire, PHEQ. Methods: Participants were patients (n = 50) diagnosed with Parkinson’s disease (n = 25) or epilepsy (n = 25), candidates for functional neurosurgery (i.e., Deep brain stimulation, anterior temporal lobectomy). At 2-3 weeks before the planned surgery, they were administrated items assessing their actual state, preoperative expectations, and hope regarding surgery outcomes. They also completed measures assessing optimism, quality of life and mood. Results: Exploratory analysis resulted in a 16-item version of the PHEQ composed of two factors (abstract representations, including psychological well-being and concrete representations, such as functional aspects of everyday functioning). The PHEQ demonstrated high internal consistency and good convergent validity. Patients were more prone to express postoperative improvements in terms of hope rather than expectations. They generally focused on concrete rather than abstract features, although patients with Parkinson’s disease had higher abstract future-oriented representations. Conclusions: The PHEQ presents satisfactory psychometric properties and may be considered as a reliable instrument for research and clinical practice.
ANALYSIS AND CLASSIFICATION OF FACTORS OF INFLUENCE ON THE VOLUME OF CAPITAL INVESTMENTS IN UKRAINE
Authors: Boronos V. , Bulbah O. , Demidova O.
Published: May 2021

The article considers the importance of capital investments for the development of enterprises, analyzes their condition and dynamics at the state level. It was found that over the past ten years, the dynamics of capital investment has not clearly increased. A number of factors that influenced their volume have been studied and analyzed, and a classification of these factors has been developed. Using economic and mathematical methods, namely correlation and regression analysis, the most important factors influencing the dynamics and structure of capital investment in Ukraine, as well as the closeness of the relationship with individual factors. The results of the study revealed the dependence of capital investment on fluctuations in GDP in Ukraine and other indicators.
BUSINESS PROCESS REENGINEERING: FROM TRADITIONAL TO DIGITAL MARKETING
Authors: Vasilyeva T. , Us Ya. , Lyulyov A. , Pimonenko T.
Published: May 2021

This article devoted to analyzing the impact of business processes digitalization on the transformation in marketing. Systematization of the scientific background indicates that digitalisation's snowballing growth has a strong influence on changes in business processes. Therefore, the authors noted that it is important to use the right digital marketing tools according to the enterprise's goals under the rapid digitalisation of business processes. This paper analyzes the main digital marketing tools and their advantages for improving business indicators. The main goal is to systematize scientific research on the relationship between business processes, digitalization, and marketing transformations. To achieve this goal, the study was conducted in several stages. The first stage affords a search for the most relevant publications in the Scopus database. The study sample consists of 1220 publications indexed by the keywords "business process", "digital", and "marketing" in the titles, keywords and abstracts of publications. The keywords include the logical operators "and" and "or" and symbol "*" to cover different keywords termination forms and enhance the search results of relevant publications. The research period is 2000-2020. The obtained search results were limited to the subject areas such as Business, Management and Accounting; Social Sciences; and Economics, Econometrics and Finance. The second stage presents a descriptive analysis of the most cited publications. The method of visualization of similarities by VOSviewer software was applied in the third stage to visualize the thematic orientation of scientific developments. The obtained results showed 8 clusters of thematic directions in studied publications. At the fourth stage of the research, the paper visualizes the authors' collaboration network according to their affiliation to a certain country. The results analysis allowed determining the countries' contribution to the investigation of study issues. The study results could be the basis for further research on the development of a digital marketing strategy.
Evaluation of the obesity influence on the life quality in patients with bronchial asthma
Authors: Zaikina Yulia , Cherednichenko Nataliia , Tymchenko Hanna , Kochuiev Gennadii , Kochuieva Maryna
Published: May 2021

The obese asthma is characterized by a more severe course. The feature of this comorbid condition is the reduced effectiveness of basic therapy with inhaled corticosteroids, which prevents optimal control of symptoms, requires increasing doses and increases the number of exacerbations and hospitalizations. The problem of life quality (LQ) research in patients with asthma and obesity is highly relevant today, which made it the reason for this study.

The aim of the study was to determine the effect of obesity on LQ in patients with asthma.

Materials and methods. We selected for participating in the study 46 patients with moderate severity asthma. Examination of the patients included: objective examination with an anthropometric evaluation, the test of the LQ with two questionnaires: general one – Medical Outcome Study SF-36 (MOS SF-36) and specialized Asthma Quality of Life Questionnaire (AQLQ).

Results. The increase in body mass index (BMI) in patients with asthma according to the questionnaires MOS SF-36 and AQLQ is associated with significant reductions in viability (r=–0.33, p<0.05), physical activity (r=–0.37, p<0.01), social activity (r=–0.36, p <0.01) and the degree of reduction of the patient's tolerance to adverse environmental factors (r=–0.29, p<0.05)

Conclusions. The presence of concomitant obesity in patients with asthma is associated with significant reductions in the parameters of physical and social activity, viability and with an increase in the subjective pain assessment (according to the questionnaire MOS SF-36) and characterized by significantly lower rates of activity, tolerance to adverse environmental factors and general life quality (according to the AQLQ questionnaire).
Confirmation that the JAHK antigen is associated with the rG haplotype
Authors: Kosanke J. , Storry J.R. , Reid M.E.
Published: May 2021

Anti-JAHK, an antibody directed toward a low-incidence antigen in the Rh system, was detected during routine antibody identification in a male donor who had no history of transfusion. Examples of anti-JAHK have been found in sera containing multiple antibodies to low-incidence antigens. The first report of anti-JAHK was in 1995 and described the association of the JAHK antigen with the rG haplotype. Our results confirm this association.
Immunohematology 2002;18:46–47.
IDENTIFICATION OF FACTORS LEADING TO EXCESSIVE WAITING TIME AT THE PHARMACY UNIT OF HEALTH CLINICS IN TEMERLOH DISTRICT, PAHANG, MALAYSIA
Authors: REN YI FONG , AHMAD AZURAINE , SAID NURUL SHAZWANI , TENGKU MANSHOR TENGKU NUR'AINI , LING LING SOO , JAMIL NORMUNIRAH , MOHD ROBY BIZURA AZIRA
Published: May 2021

Excessive patient waiting time at dispensing pharmacies is attributed to workflow inefficiencies that are difficult to isolate. The objectives of this study are to quantify current operational process and delay times and also to identify bottlenecks that lead to excessive waiting time at the pharmacy unit of primary health clinics in Temerloh district. A multicentre observational cohort study was conducted at a Pharmacy Unit of Bandar Mentakab Health Clinic (KKBM), Temerloh Health Clinic (KKT) and Tanjung Lalang Health Clinic (KKTL). Stopwatch technique was applied for all four operational procedures (greeting, data entry, filling and dispensing) based on workflow analysis. Data collection forms were used to identify factors and their impact on process time. Major components causing long waiting times were found in delay segments. Significant time delay occurred before greeting at KKT; before data entry at KKBM, KKT and KKTL; and before dispensing at KKTL. Among factors found affecting process segment in data entry include presence of intervention and psychotropic substances in the prescription. Filling process was found to be delayed by the presence of more than three items, cold items, intervention and psychotropic substances in the prescription. In addition, dispensing process was found to be delayed by errors in data entry and filling. This study identified several common bottlenecks and isolated issues specific to each pharmacy unit of three health clinics that lead to excessive operational process and delay times in pharmacy dispensing process. This approach laid a solid base to spearhead future optimisation strategies to improve efficiency and shorten waiting time.
Problems of export of educational services of the Russian Federation
Authors:   ", Kuzmina Violetta ,   South-West State University"
Published: May 2021

Currently, the export of educational services is a global business, which is aimed at making a profit and opportunities to expand cultural and economic ties between countries through the implementation of educational services to “consumers” of the educational services market.
Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta
and Neurofibrillary Tangle Pathways in Alzheimer's Disease
Authors: Freeman Jennifer L. , Kiper Keturah
Published: May 2021

:

The prevalence of neurodegenerative diseases is increasing globally, with an imperative
need to identify and expand the availability of pharmaceutical treatment strategies. Alzheimer's disease
is the most common neurodegenerative disease for which there is no cure and limited treatments.
Rodent models are primarily used in Alzheimer's disease research to investigate causes, pathology,
molecular mechanisms, and pharmaceutical therapies. However, there is a lack of a comprehensive
understanding of Alzheimer's disease causes, pathogenesis, and optimal treatments due
in part to some limitations of using rodents, including higher economic cost, which can influence
sample size and ultimately statistical power. It is necessary to expand our animal model toolbox to
provide alternative strategies in Alzheimer's disease research. The zebrafish application in neurodegenerative
disease research and neuropharmacology is greatly expanding due to several vital
strengths spanning lower economic costs, the smaller size of the organism, a sequenced characterized
genome, and well described anatomical structures. These characteristics are coupled to the conserved
molecular function and disease pathways in humans. The existence of orthologs for genes associated
with Alzheimer's disease in zebrafish is also confirmed. While wild-type zebrafish appear
to lack some of the neuropathological features of Alzheimer's disease, the advent of genetic editing
technologies has expanded the evaluation of the amyloid and neurofibrillary tangle hypotheses using
the zebrafish and exploration of pharmaceutical molecular targets. An overview of how genetic editing
technologies are being used on the zebrafish to create models to investigate the causes, pathology,
molecular mechanisms, and pharmaceutical targets of Alzheimer's disease is detailed.
Covid-19 Mortality Rates in Northamptonshire UK: Initial Sub-regional Comparisons and Provisional SEIR model of First Wave Disease Spread
Authors: Petford Nick , Campbell Jackie
Published: May 2021

We analysed mortality rates in a non-metropolitan UK subregion (Northamptonshire) using statistically-weighted data fitted to the start of the epidemic to quantify SARS-CoV-2 disease fatalities at sub 1,000,000 population levels. Using parameter estimates derived from the recorded mortality data, a numerical (SEIR) model was developed to predict the spread of Covid-19 sub regionally. Model outputs, including analysis of transmission rates and the basic reproduction number, suggest national lockdown flattened the curve and reduced potential deaths by up to 4000 locally. The modelled number of infected and recovered individuals is higher than official estimates, and a revised form of the theoretical critical population fraction requiring immunisation is derived. Combining published (sub-regional) mortality rate data with deterministic models on disease spread has the potential to help public health practitioners refine bespoke mitigation plans guided by local population demographics.
AİLE HEKİMLİĞİNDE NADİR GÖRÜLEN BİR OLGU: ACETAMİPRİD ZEHİRLENMESİ
Authors: ÇAKIR Meryem , ALMAK Deniz , ÖNGEL Kurtuluş
Published: May 2021

Neonikotinoidler, yeni bir insektisid grubu olup, özellikle mahsullerin korunmasında yaygın olarak kullanılmaktadır. Aile Hekimliği uygulamalarında, acetamiprid gibi insektisitlere bağlı zehirlenmeler ile nadirende olsa karşılaşılabilmektedir. Semptomları, pek çok hastalık ile karışabilen acetamiprid zehirlenmesinin birinci basamak hekimlerince tanınabilmesi önemlidir. Bu vaka takdimi ile, %20 acetamipride deri ve inhalasyon yolu ile maruziyet sonrası, klinik semptom gelişen 40 yaşında bir erkek hastaya klinik yaklaşımın sunulması amaçlanmıştır.
Babaların psikolojik sağlamlık düzeyleriyle çocuk bakımına katılım düzeyleri arasındaki ilişki: Adana örneği
Authors: BİLGE Merve , AVCI Ayse , KALE Mustafa
Published: May 2021

Amaç: Bu araştırmada, okul öncesi çağında çocuğu olan babaların psikolojik sağlamlık düzeyleri ile çocuklarının bakım uygulamalarına katılımları arasındaki ilişki incelenmiştir. Yöntem: Mevcut araştırma, nicel araştırma yöntemi ile ele alınmış olup, ilişkisel tarama modelinde kesitsel tipte bir çalışmadır. Araştırmaya, Adana ilinin Seyhan ve Çukurova ilçelerindeki anaokullarında eğitime devam eden 240 çocuğun babaları dahil edilmiştir. Araştırmaya katılan babalara, Baba Katılım Ölçeği ve Yetişkin Psikolojik Sağlamlık Ölçeği uygulanarak, babaların psikolojik sağlamlıkları ile çocuk bakım uygulamalarına katılımları arasındaki ilişkiye bakılmıştır. Araştırmada elde edilen veriler, SPSS 23.0 programı kullanılarak analiz edilmiştir. Verilerin değerlendirilmesinde, tanımlayıcı istatistiksel yöntemleri olarak sayı, yüzde, ortalama ve standart sapma kullanılmıştır. Bulgular: Araştırmada yer alan babaların, baba katılımları ile yaş grupları arasında anlamlı bir farklılık tespit edilmiştir (p = 0,001). 40-45 yaşları arasındaki babaların, çocuk bakım uygulamalarına katılımlarının 25-30 yaşları, 31-35 yaşları ve 45 ve üzerinde yaşlarındaki babalara göre istatistiksel olarak daha yüksek olduğu belirlenmiştir. Babaların, psikolojik sağlamlık düzeyleri ile yaş grubu arasında anlamlı bir farklılığın bulunmadığı tespit edilmiştir. Aynı şekilde, babaların psikolojik sağlamlık düzeyleri ile eğitim düzeyi arasında (p = 0,760) anlamlı bir farklılığın bulunmadığı tespit edilmiştir. “Baba Katılım Ölçeği” toplam puanı ile “Yetişkin Psikolojik Sağlamlık Ölçeği” toplam puanı arasında pozitif yönlü, orta düzeyde anlamlı bir ilişki olduğu görülmektedir (r = .43; p < .01). Sonuç: Araştırmada elde edilen bulgular, çocuk bakım uygulamalarına katılım toplam puanı ve keyfi meşguliyet, ilgi ve yakınlık, temel bakım alt boyutları ile psikolojik sağlamlık puanlarının pozitif yönlü anlamlı olarak ilişkili olduğu yönünde bulunmuştur. Babaların, psikolojik sağlamlık düzeyleri arttıkça, çocuklarının bakım uygulamalarına katılımlarının da arttığı sonucuna ulaşılmıştır.
Wartość „dojrzała miłość” w systemie wartości młodzieży
Authors:   Uniwersytet Jana Kochanowskiego w Kielcach, Wojciechowska Mariola , Adamczyk Dariusz ,   Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Published: May 2021

As regards the axiological hierarchy, the love-as-a-gift is particularly important in interperso- nal relations. It means the value of a person-as-a-gift to another person. The complete experience of love between a man and a woman demands its ethical dimension. Its natural fulfilment is marriage as self-giving. Studies conducted among high school youth with the use of Milton Rokeach's RVS Scale, confirm that the value of mature love in the group of terminal values, and the value of loving in the group of instrumental values are highly cherished. The leading (central) position of the analysed values indicates their impact upon young people's behaviour.
Ochrona dziecka z perspektywy cywilnoprawnej – wybrane zagadnienia
Authors:   Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie, Kałdon Barbara Małgorzata
Published: May 2021

Care for the welfare of the youngest family members is one of the main goals of the legislator. A properly functioning family does not require state interference as long as it does not deviate from the generally accepted standards. However, if such a situation occurs, it is necessary to undertake legal mechanisms aimed at restoring the proper functioning of the family. Consequently, various branches of the law regulate instruments to help the family overcome the crisis which it undergoes. The article presents selected areas of civil law child protection referring to such issues as prohibi- tion of using corporal punishment against a minor and the consequences of its violation, other forms of abusing parental authority, as well as the regulation of certain relations between parents and children.
Zakład zdrojowy diecezji przemyskiej w Brzozowie 1927-1948
Authors:   Akademia Wychowania Fizycznego J. Piłsudskiego w Warszawie, Piekarski Stanisław
Published: May 2021

The purpose of this article is to present aspects related to building and maintaining health and leisure centre of the Przemyśl Diocese in Brzozów - largely based on voluntary taxation. The Diocese was the most successful in this area of health prevention in the interwar period. Within several months, the faithful of the Church and the clergy of this region - under the aegis of Bishop Anatol Nowak - managed to open in summer 1927 the magnificent spa facility with its own brine and baths accessible for clergy and seminarians. No Polish professional community recorded such success in the interwar period. The health and leisure centre was manager under the authority of the bishopric by the Congregation of the Sisters Servants of the Blessed Virgin Mary Immaculate from Nowa Wieś. During the occupation The Przemyśl Seminary was placed in the centre. In parallel, both German and Soviet soldiers used the spa facility. After the war, the spa did not manage to return to its pre-war splendor. It definitively ceased to exist in 1948.
Acceptability of Research and Health Care Visits During the COVID-19 Pandemic: Cross-sectional Survey Study
Authors: Ross Kathryn M , Hong Young-Rock , Krukowski Rebecca A , Miller Darci R , Lemas Dominick J , Cardel Michelle I
Published: May 2021

Background

The COVID-19 pandemic has had a widespread impact on attendance in biomedical research and health care visits.

Objective

This study aimed to identify when and how American adults might feel comfortable about resuming in-person research and health care visits.

Methods

Cross-sectional questionnaire data were collected from 135 adults (age: median 48 years; women: n=113, 83.7%; White participants: n=92, 68.2%) who were engaged in health-related research.

Results

More than half of the respondents (65/122, 53.3%) felt that the COVID-19 pandemic positively affected their desire to participate in research. Although 73.6% (95/129) of respondents also indicated a willingness to attend in-person health care visits while Centers for Disease Control and Prevention (CDC) guidelines are implemented, 85.8% (109/127) indicated a willingness to attend in-person, outdoor visits, and 92.2% (118/128) reported a willingness to attend drive-through visits (with CDC guidelines implemented during both visit types). Videoconferencing was the most preferred format for intervention visits; however, adults over the age of 65 years preferred this format less than younger adults (P=.001).

Conclusions

Researchers and clinicians should continue to provide opportunities for continuing the conduction of remote-based interventions while enforcing CDC guidelines during in-person visits.
Building on Lessons Learned in a Mobile Intervention to Reduce Pain and Improve Health (MORPH): Protocol for the MORPH-II Trial
Authors: Fanning Jason , Brooks Amber K , Hsieh Katherine L , Kershner Kyle , Furlipa Joy , Nicklas Barbara J , Rejeski W Jack
Published: May 2021

Background

Engaging in sufficient levels of physical activity, guarding against sustained sitting, and maintaining a healthy body weight represent important lifestyle strategies for managing older adults’ chronic pain. Our first Mobile Health Intervention to Reduce Pain and Improve Health (MORPH) randomized pilot study demonstrated that a partially remote group-mediated diet and daylong activity intervention (ie, a focus on moving often throughout the day) can lead to improved physical function, weight loss, less pain intensity, and fewer minutes of sedentary time. We also identified unique delivery challenges that limited the program’s scalability and potential efficacy.

Objective

The purpose of the MORPH-II randomized pilot study is to refine the MORPH intervention package based on feedback from MORPH and evaluate the feasibility, acceptability, and preliminary efficacy of this revised package prior to conducting a larger clinical trial.

Methods

The MORPH-II study is an iteration on MORPH designed to pilot a refined framework, enhance scalability through fully remote delivery, and increase uptake of the daylong movement protocol through revised education content and additional personalized remote coaching. Older, obese, and low-active adults with chronic multisite pain (n=30) will be randomly assigned to receive a 12-week remote group-mediated physical activity and dietary weight loss intervention followed by a 12-week maintenance period or a control condition. Those in the intervention condition will partake in weekly social cognitive theory–based group meetings via teleconference software plus one-on-one support calls on a tapered schedule. They will also engage with a tablet application paired with a wearable activity monitor and smart scale designed to provide ongoing social and behavioral support throughout the week. Those in the control group will receive only the self-monitoring tools.

Results

Recruitment is ongoing as of January 2021.

Conclusions

Findings from MORPH-II will help guide other researchers working to intervene on sedentary behavior through frequent movement in older adults with chronic pain.

Trial Registration

ClinicalTrials.gov NCT04655001; https://clinicaltrials.gov/ct2/show/NCT04655001

International Registered Report Identifier (IRRID)

PRR1-10.2196/29013
The Impact of a Gameful Breathing Training Visualization on Intrinsic Experiential Value, Perceived Effectiveness, and Engagement Intentions: Between-Subject Online Experiment (Preprint)
Authors: Lukic Yanick Xavier , Klein Shari Shirin , Brügger Victoria , Keller Olivia Clare , Fleisch Elgar , Kowatsch Tobias
Published: May 2021

BACKGROUND

Slow-paced breathing has been shown to be positively associated with psychological and physiological health. In practice, however, there is little long-term engagement with breathing training, as shown by the usage statistics of breathing training apps. New research suggests that gameful smartphone-delivered breathing training may address this challenge.

OBJECTIVE

This study assesses the impact of breathing training, guided by a gameful visualization, on perceived experiential and instrumental values and the intention to engage in such training.

METHODS

A between-subject online experiment with 170 participants was conducted, and one-way multiple analysis of variance and two-tailed t test analyses were used to test for any difference in intrinsic experiential value, perceived effectiveness, and the intention to engage in either a breathing training with a gameful or a nongameful guidance visualization. Moreover, prior experience in gaming and meditation practices were assessed as moderator variables for a preliminary analysis.

RESULTS

The intrinsic experiential value for the gameful visualization was found to be significantly higher compared to the nongameful visualization (P=.001), but there was no difference in either perceived effectiveness (P=.50) or the intention to engage (P=.44). The preliminary analysis of the influence of meditation and gaming experience on the outcomes indicates that people with more meditation experience yielded higher intrinsic experiential values from using the gameful visualization than people with no or little meditation experience (P=.03). This analysis did not find any additional evidence of gaming time or meditation experience impacting the outcomes.

CONCLUSIONS

The gameful visualization was found to increase the intrinsic experiential value of the breathing training without decreasing the perceived effectiveness. However, there were no differences in intentions to engage in both breathing training conditions. Furthermore, gaming and meditation experiences seem to have no or only a small positive moderating effect on the relationship between the gameful visualization and the intrinsic experiential value. Future longitudinal field studies are required to assess the impact of gameful breathing training on actual behavior, that is, long-term engagement and outcomes.
Research Status of High Clearance Sprayer and Its Steering System at Home and Abroad
Authors: Youneng Long
Published: May 2021

This paper introduces the representative domestic and foreign high-gap sprayer models, and expounds the current research status of the steering system of the high-gap sprayer, which provides reference for the further development of high-gap sprayer and other products in domestic enterprises and universities.
АВТОМАТИЗИРОВАННЫЙ ЭЛЕКТРОПРИВОД ТЕХНОЛОГИЧЕСКИХ ОБЪЕКТОВ С ЭЛЕКТРОННОЙ СИНХРОНИЗАЦИЕЙ ДВИЖЕНИЙ МЕХАНИЗМОВ
Authors: Подзоров Н. , Осипов О.
Published: May 2021

Уход от связанной кинематики, переход к индивидуальному взаимосвязанному электроприводу позволяют повысить производительность, понизить требования к квалификации оператора и достичь более высокой точности конечного продукта. Рассмотрено развязывание кинематики зубофрезерного станка 53А30 с применением электронной синхронизации инструмента и заготовки. Рассматривается вариант электронной синхронизации в машинах горячего тиснения.
On the formation of the nightside ionospheric bulge in the Venus wake
Authors: Pérez de Tejada H. , Brace L. H.
Published: May 2021

Se presenta un estudio de la distribución de la posición de la ionosfera del planeta Venus conforme a las observaciones hechas en el experimento de medición de temperatura de electrones con la sonda Pionero Venus. Los resultados de este estudio son examinados en conexión con la geometría de la prominencia ionosférica nocturna de ese planeta. Se demuestra que la evidencia experimental indica que además de mostrar alturas decrecientes con latitud, la prominencia se presenta menos frecuentemente a altas latitudes. Este resultado es consistente con las predicciones del modelo viscoso y la penetración de partículas del viento solar hacia la umbra planetaria por el terminador polar.
Resultados gravimétricos sobre la cuenca del Golfo de San Jorge (Rep. Arg.)
Authors: Introcaso A.
Published: May 2021

Se analizan los resultados gravimétricos continentales a través de dos secciones perpendiculares que atraviesan la cuenca del Golfo de San Jorge de N a S y de E a W. Hacia el centro del Golfo se encuentra un máximo gravimétrico sobre un potente desarrollo sedimentario, que corregido por "efecto de cuenca" incrementa considerablemente sus valores. Las características de tal anomalía gravimétrica indican excesos de masas emplazados en altos niveles intracorticales, vinculados tal vez a la subsidencia inicial. El potente desarrollo sedimentario formado ulteriormente, induciría reacciones isostáticas.