bluuebunny/crossref_metadata_2025 huggingface dataset:
Patients with Clinically Suspected Gallstone Disease: A More Selective Ultrasound May Improve Treatment Related Outcomes
Authors: Thunnissen Floris M. , Comes Daan J. , Geenen Remy W. F. , Riviere Deniece , Latenstein Carmen S. S. , Lantinga Marten A. , Schers Henk J. , van Laarhoven Cornelis J. H. M. , Drenth Joost P. H. , Atsma Femke , de Reuver Philip R.
Published: June 2023

This study aimed to quantify the confirmation of gallstones on ultrasound (US) in patients with suspicion of gallstone disease. To aid general practitioners (GPs) in diagnostic workup, a model to predict gallstones was developed. A prospective cohort study was conducted in two Dutch general hospitals. Patients (≥18 years) were eligible for inclusion when referred by GPs for US with suspicion of gallstones. The primary outcome was the confirmation of gallstones on US. A multivariable regression model was developed to predict the presence of gallstones. In total, 177 patients were referred with a clinical suspicion of gallstones. Gallstones were found in 64 of 177 patients (36.2%). Patients with gallstones reported higher pain scores (VAS 8.0 vs. 6.0, p < 0.001), less frequent pain (21.9% vs. 54.9%, p < 0.001), and more often met criteria for biliary colic (62.5% vs. 44.2%, p = 0.023). Predictors for the presence of gallstones were a higher pain score, frequency of pain less than weekly, biliary colic, and an absence of heartburn. The model showed good discrimination between patients with and without gallstones (C-statistic 0.73, range: 0.68–0.76). Clinical diagnosis of symptomatic gallstone disease is challenging. The model developed in this study may aid in the selection of patients for referral and improve treatment related outcomes.
Single-Center Real-World Experience with Sutureless Aortic Valve Prosthesis in Isolated and Combined Procedures
Authors: Zubarevich Alina , Amanov Lukman , Arjomandi Rad Arian , Beltsios Eleftherios T. , Szczechowicz Marcin , Osswald Anja , Ruhparwar Arjang , Weymann Alexander
Published: June 2023

Introduction: Due to their favourable hemodynamic performance and the ability to enable minimally invasive access procedures, sutureless aortic valve prostheses have found their place in the armamentarium of cardiothoracic surgeons. In this study, we sought to review our institutional experience of sutureless aortic valve replacement (SU-AVR). Methods: We carried out a retrospective analysis of 200 consecutive patients who underwent an SU-AVR with a Perceval valve between December 2019 and February 2023. Results: The mean age of patients was 69.3 ± 8.1 years, and patients showed a moderate-risk profile with a mean logistic EuroSCORE-II of 5.2 ± 8.1%. An isolated SU-AVR was performed in 85 (42.5%) patients, concomitant CABG was performed in 75 (37.5%) and 40 patients (20%) underwent a multivalve procedure involving SU-AVR. The cardiopulmonary bypass (CPB) and cross-clamp (CC) times were 82.1 ± 35.1 and 55.5 ± 27.8 min, respectively. In-hospital, 30-day, 6-month and 1-year mortality rates were 4.5%, 6.5%, 7.5% and 8.2%, respectively. The postoperative transvalvular mean pressure gradient was 6.3 ± 1.6 mmHg and stayed stable over the follow-up time. We reported no cases of paravalvular leakage, and the incidence of stroke was 0.5%. Conclusions: With their favourable hemodynamic performance and shorter CC and CPB times, sutureless aortic valve prostheses facilitate minimally invasive access surgery, being a safe and durable promising approach for the surgical AVR.
Anti-Inflammatory Drug Therapy in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis of Prospective Randomized and Placebo-Controlled Trials
Authors: Wach Johannes , Vychopen Martin , Güresir Agi , Güresir Erdem
Published: June 2023

Emerging evidence suggests that neuroinflammation may play a potential role in aneurysmal subarachnoid hemorrhage (aSAH). We aim to analyze the influence of anti-inflammatory therapy on survival and outcome in aSAH. Eligible randomized placebo-controlled prospective trials (RCTs) were searched in PubMed until March 2023. After screening the available studies for inclusion and exclusion criteria, we strictly extracted the main outcome measures. Dichotomous data were determined and extracted by odds ratio (OR) with 95% confidence intervals (CIs). Neurological outcome was graded using the modified Rankin Scale (mRS). We created funnel plots to analyze publication bias. From 967 articles identified during the initial screening, we included 14 RCTs in our meta-analysis. Our results illustrate that anti-inflammatory therapy yields an equivalent probability of survival compared to placebo or conventional management (OR: 0.81, 95% CI: 0.55–1.19, p = 0.28). Generally, anti-inflammatory therapy trended to be associated with a better neurologic outcome (mRS ≤ 2) compared to placebo or conventional treatment (OR: 1.48, 95% CI: 0.95–2.32, p = 0.08). Our meta-analysis showed no increased mortality form anti-inflammatory therapy. Anti-inflammatory therapy in aSAH patients tends to improve the neurological outcome. However, multicenter, rigorous, designed, prospective randomized studies are still needed to investigate the effect of fighting inflammation in improving neurological functioning after aSAH.
Ocular Distribution of Brimonidine and Brinzolamide after Topical Instillation of a 0.1% Brimonidine Tartrate and 1% Brinzolamide Fixed-Combination Ophthalmic Suspension: An Interventional Study
Authors: Orii Yusuke , Kunikane Eriko , Yamada Yutaka , Morioka Masakazu , Iwasaki Kentaro , Arimura Shogo , Mizuno Akemi , Inatani Masaru
Published: June 2023

Purpose: To evaluate the concentrations of brimonidine and brinzolamide in the vitreous and aqueous humor after instillation of a 0.1% brimonidine tartrate and 1% brinzolamide fixed-combination ophthalmic suspension. Methods: The present investigation involved patients with macular holes or idiopathic epiretinal membranes who were planning to undergo vitrectomy. One week prior to surgery, the patients received twice-daily topical treatment with 0.1% brimonidine tartrate and 1% brinzolamide fixed-combination ophthalmic suspension. Before vitrectomy, vitreous and aqueous humor samples were collected, and the mean concentrations of brimonidine and brinzolamide were determined through liquid chromatography-tandem spectrometry. Results: Ten eyes (nine phakic and one pseudophakic eyes; 10 patients) were examined. The concentration of brimonidine in vitreous and aqueous humor samples was 5.02 ± 2.24 and 559 ± 670 nM, respectively. The concentration of brimonidine in the vitreous humor, which is needed to activate α2 receptors, was >2 nM in all patients. The concentration of brinzolamide was 8.96 ± 4.65 and 1100 ± 813 nM, respectively. However, there was no significant correlation between the concentrations of brimonidine in the vitreous and aqueous humor samples. Conclusions: Sufficient concentrations of brimonidine were detected in all vitreous samples. The dissociated correlation of the drug concentrations between aqueous and vitreous humors implies the possibility of another pathway to vitreous humor, different from the pathway to aqueous humor.
Magnesium-Based Temporary Implants: Potential, Current Status, Applications, and Challenges
Authors: Seetharaman Sankaranarayanan , Sankaranarayanan Dhivya , Gupta Manoj
Published: June 2023

Biomedical implants are important devices used for the repair or replacement of damaged or diseased tissues or organs. The success of implantation depends on various factors, such as mechanical properties, biocompatibility, and biodegradability of the materials used. Recently, magnesium (Mg)-based materials have emerged as a promising class of temporary implants due to their remarkable properties, such as strength, biocompatibility, biodegradability, and bioactivity. This review article aims to provide a comprehensive overview of current research works summarizing the above-mentioned properties of Mg-based materials for use as temporary implants. The key findings from in-vitro, in-vivo, and clinical trials are also discussed. Further, the potential applications of Mg-based implants and the applicable fabrication methods are also reviewed.
pH-Activated Dissolvable Polymeric Coatings to Reduce Biofouling on Electrochemical Sensors
Authors: Uçar Ahmet , González-Fernández Eva , Staderini Matteo , Murray Alan F. , Mount Andrew R. , Bradley Mark
Published: June 2023

Implantable electrochemical sensors that enable the real-time detection of significant biomarkers offer huge potential for the enhancement and personalisation of therapies; however, biofouling is a key challenge encountered by any implantable system. This is particularly an issue immediately after implantation, when the foreign body response and associated biofouling processes are at their most active in passivating a foreign object. Here, we present the development of a sensor protection and activation strategy against biofouling, based on coatings consisting of a pH-triggered, dissolvable polymer, that covered a functionalised electrode surface. We demonstrate that reproducible delayed sensor activation can be achieved, and that the length of this delay can be controlled by the optimisation of coating thickness, homogeneity and density through tuning of the coating method and temperature. Comparative evaluation of the polymer-coated and uncoated probe-modified electrodes in biological media revealed significant improvements in their anti-biofouling characteristics, demonstrating that this offers a promising approach to the design of enhanced sensing devices.
Thermoelectric Freeze-Casting of Biopolymer Blends: Fabrication and Characterization of Large-Size Scaffolds for Nerve Tissue Engineering Applications
Authors: Monfette Vincent , Choinière William , Godbout-Lavoie Catherine , Pelletier Samuel , Langelier Ève , Lauzon Marc-Antoine
Published: June 2023

Peripheral nerve injuries (PNIs) are detrimental to the quality of life of affected individuals. Patients are often left with life-long ailments that affect them physically and psychologically. Autologous nerve transplant is still the gold standard treatment for PNIs despite limited donor site and partial recovery of nerve functions. Nerve guidance conduits are used as a nerve graft substitute and are efficient for the repair of small nerve gaps but require further improvement for repairs exceeding 30 mm. Freeze-casting is an interesting fabrication method for the conception of scaffolds meant for nerve tissue engineering since the microstructure obtained comprises highly aligned micro-channels. The present work focuses on the fabrication and characterization of large scaffolds (35 mm length, 5 mm diameter) made of collagen/chitosan blends by freeze-casting via thermoelectric effect instead of traditional freezing solvents. As a freeze-casting microstructure reference, scaffolds made from pure collagen were used for comparison. Scaffolds were covalently crosslinked for better performance under load and laminins were further added to enhance cell interactions. Microstructural features of lamellar pores display an average aspect ratio of 0.67 ± 0.2 for all compositions. Longitudinally aligned micro-channels are reported as well as enhanced mechanical properties in traction under physiological-like conditions (37 °C, pH = 7.4) resulting from crosslinking treatment. Cell viability assays using a rat Schwann cell line derived from sciatic nerve (S16) indicate that scaffold cytocompatibility is similar between scaffolds made from collagen only and scaffolds made from collagen/chitosan blend with high collagen content. These results confirm that freeze-casting via thermoelectric effect is a reliable manufacturing strategy for the fabrication of biopolymer scaffolds for future peripheral nerve repair applications.
Investigation of the Real-Time Release of Doxycycline from PLA-Based Nanofibers
Authors: Farkas Noémi-Izabella , Marincaș Laura , Barbu-Tudoran Lucian , Barabás Réka , Turdean Graziella Liana
Published: June 2023

Electrospun mats of PLA and PLA/Hap nanofibers produced by electrospinning were loaded with doxycycline (Doxy) through physical adsorption from a solution with initial concentrations of 3 g/L, 7 g/L, and 12 g/L, respectively. The morphological characterization of the produced material was performed using scanning electron microscopy (SEM). The release profiles of Doxy were studied in situ using the differential pulse voltammetry (DPV) electrochemical method on a glassy carbon electrode (GCE) and validated through UV-VIS spectrophotometric measurements. The DPV method has been shown to be a simple, rapid, and advantageous analytical technique for real-time measurements, allowing accurate kinetics to be established. The kinetics of the release profiles were compared using model-dependent and model-independent analyses. The diffusion-controlled mechanism of Doxy release from both types of fibers was confirmed by a good fit to the Korsmeyer–Peppas model.
Recurrent Scedosporium apiospermum Cutaneous Infection in a Patient with Rheumatoid Arthritis: The Potent Role of IL-6 Signaling Pathway Blockade: A Case-Based Review
Authors: Pieta Antigone , Venetsanopoulou Aliki I. , Kittas Christos , Christaki Eirini , Voulgari Paraskevi V.
Published: June 2023

Rheumatoid arthritis (RA) patients deal with a higher risk of bacterial and fungal infections compared to the general population because of their dysregulated immune system as well as the immunosuppressive therapy they usually receive. Scedosporium spp. is a fungal pathogen responsible for cutaneous, lung, central nervous system, and eye infections, mostly in immunocompromised patients, leading to death in disseminated cases. We report the case of an 81-year-old woman with rheumatoid arthritis treated with steroids and an IL-6 inhibitor who was diagnosed with scedosporiosis of the upper limb. She was treated with voriconazole for one month, which was discontinued due to adverse events, and when scedosporiosis relapsed, she switched to itraconazole. We also reviewed the current literature on RA patients presenting with Scedosporium infections. Early and accurate diagnosis of scedosporiosis has therapeutic and prognostic implications, as traditionally this fungus is resistant to commonly used antifungals. Clinical alertness regarding uncommon infections, including fungal, in patients with autoimmune diseases on immunomodulatory agents is essential for effective treatment.
A Critical Review of the Prognostic and Predictive Implications of KRAS and STK11 Mutations and Co-Mutations in Metastatic Non-Small Lung Cancer
Authors: Manolakos Peter , Ward Linda D.
Published: June 2023

The Kirsten rat sarcoma viral oncogene homolog (KRAS) and serine/threonine kinase 11 (STK11) co-mutations are associated with the diverse phenotypic and heterogeneous oncogenic subtypes in non-small cell lung cancer (NSCLC). Due to extensive mixed evidence, there needs to be a review of the recent KRAS and STK11 mutation literature to better understand the potential clinical applications of these genomic biomarkers in the current treatment landscape. This critical review highlights the clinical studies that have elucidated the potential prognostic and predictive implications of KRAS mutations, STK11 mutations, or KRAS/STK11 co-mutations when treating metastatic NSCLC across various types of treatments (e.g., immune checkpoint inhibitors [ICIs]). Overall, KRAS mutations are associated with poor prognoses and have been determined to be a valid but weak prognostic biomarker among patients diagnosed with NSCLC. KRAS mutations in NSCLC have shown mixed results as a predictive clinical biomarker for immune checkpoint inhibitor treatment. Overall, the studies in this review demonstrate that STK11 mutations are prognostic and show mixed results as predictive biomarkers for ICI therapy. However, KRAS/STK11 co-mutations may predict primary resistance to ICI. Prospective KRAS/STK11-biomarker-driven randomized trials are needed to assess the predictive effect of various treatments on the outcomes for patients with metastatic NSCLC, as the majority of the published KRAS analyses are retrospective and hypothesis-generating in nature.
Total Joint Replacement for Immediate Reconstruction following Ablative Surgery for Primary Tumors of the Temporo-Mandibular Joint
Authors: Gonzalez-Perez Luis-Miguel , Montes-Carmona Jose-Francisco , Torres-Carranza Eusebio , Infante-Cossio Pedro
Published: June 2023

Temporomandibular joint (TMJ) tumors are rare and difficult to diagnose. The purpose of this retrospective study was to evaluate the clinicopathologic characteristics of twenty-one patients with primary TMJ tumors between 2010 and 2019 and to analyze the surgical outcome and morbidity after ablative surgery and TMJ replacement. This case series confirmed the difficulty of diagnosis and reaffirmed the need for early recognition and management of TMJ tumors. There were no pathognomonic findings associated with TMJ tumors, although single or multiple radiopaque or radiolucent areas were observed on plain or panoramic radiographs. Occasionally, bone resorption or mottled densities caused by pathologic calcification and ossification were seen. Computed tomography and magnetic resonance imaging played an important role in the diagnosis. In our study, the distribution of histologic types of TMJ tumors was quite different from that of other joint tumors. The recommended treatment was surgical intervention by ablation of the joint and TMJ replacement. The results of this retrospective study support the surgical exeresis and replacement with TMJ stock and custom-made prostheses and show that the approach is efficacious and safe, reduces pain and improves mandibular movements, with few complications.
Soil Quality Evaluation Based on a Minimum Data Set (MDS)—A Case Study of Tieling County, Northeast China
Authors: Qian Fengkui , Yu Yuanjun , Dong Xiuru , Gu Hanlong
Published: June 2023

Soil quality is related to food security and human survival and development. Due to the acceleration of urbanization and the increase in abandoned land, the quality of topsoil has deteriorated, thus resulting in land degradation in recent years. In this study, a minimum data set (MDS) was constructed through principal component analysis (PCA) to determine the indicator data set for evaluating topsoil quality in Tieling County, northeast China. In addition, the soil quality index (SQI) was calculated to analyze the spatial distribution characteristics of the topsoil quality and the influencing factors. The results showed that the MDS included total potassium (TK), clay, zinc (Zn), soil organic matter (SOM), soil water content (SWC), cation exchange capacity (CEC), pH, and copper (Cu), which could replace all other indicators for assessing the topsoil quality in the research region. The overall soil quality of Tieling County showed a trend of being low in the east and high in the west, and it gradually increased from the hilly area to the plain area. The topsoil quality of Tieling County is divided into one to five levels, with grade-I being the best and grade-V being the worst. The proportion of Grade-II and grade-III is the largest, which is 28.5% and 26.3%, respectively, and grade-V is the smallest, which is 9.6%. The evaluation results are consistent with field research, which can provide a reference for other topsoil quality evaluations, and it also provides a basis for the formulation of soil quality improvement measures.
Spatial-Temporal Evolution and Prediction of Carbon Storage in Areas Rich in Ancient Remains: A Case Study of the Zhouyuan Region, China
Authors: Chen Jian , Zhang Xiaoxiao , Wang Kai , Yan Zhenguo , Zhang Wei , Niu Lixin , Zhang Yanlong
Published: June 2023

In the past few decades, human activities have caused the emission of large amounts of carbon dioxide, which has severely impacted the Earth’s ecosystem and human health. Therefore, carbon reduction has become the focus of global attention. In this study, the Zhouyuan region of China, which is rich in ancient remains, is taken as an example. Based on the land use characteristics in 1990, 2000, 2010, and 2020, the spatial-temporal evolution of land use and carbon storage in the Zhouyuan region is simulated using four methods, including land use classification, land use transfer maps, patch-level land-use simulation (PLUS), and the integrated valuation of ecosystem services and trade-offs (InVEST) models under three scenarios, including the natural development scenario, urban development priority, and heritage conservation priority in 2030. According to the results, the carbon storage in the area in 2030 under all three scenario simulations has decreased compared with 2020, indicating that the region faces great challenges in achieving its targets of carbon peak and carbon neutrality. The paper points out four causes for the decrease in carbon storage, and five suggestions for increasing carbon storage are proposed, such as developing a carbon storage master plan, applying energy-saving technologies, establishing an ecological substitution mechanism, and so on. Through the study of carbon storage in the Zhouyuan region, this paper hopes to establish a mechanism to balance urban development, heritage conservation, and carbon sinks on the one hand, and encourage more scholars to participate in the study of carbon sinks in areas rich in ancient remains, so as to to jointly promote their healthy development on the other.
Atopic Dermatitis: Disease Features, Therapeutic Options, and a Multidisciplinary Approach
Authors: Lugović-Mihić Liborija , Meštrović-Štefekov Jelena , Potočnjak Ines , Cindrić Tea , Ilić Ivana , Lovrić Ivan , Skalicki Lucija , Bešlić Iva , Pondeljak Nives
Published: June 2023

The latest findings regarding AD pathogenesis point to an impaired function of the epidermal barrier, changed immune response, colonization of the skin by microorganisms, and certain psychological factors among other causes/triggers. The inflammatory response of AD patients is mainly associated with the activation of T cells (Th2 cells predominate), dendritic cells, macrophages, keratinocytes, mast cells, and eosinophils. Therapy usually involves medical evaluations and adequate management including treatment of concomitant diseases (e.g., allergies and infections), patient education and nursing care, psychological support, and nutritional consultations, which are organized through specific programs and structured educational groups. Systemic AD therapy includes conventional systemic treatment (cyclosporine, methotrexate, azathioprine) and new, specific drugs, interleukin inhibitors (e.g., dupilumab) and JAK inhibitors (baricitinib, abrocitinib, upadacitinib, etc.). Since many AD patients are affected by various psychological factors and comorbidities, they should be assessed and managed through a multidisciplinary approach, involving different professions (psychologists, ear–nose–throat specialists, pulmonologists, allergologists, immunologists, nutritionists, pediatricians, gastroenterologists, psychiatrists (when necessary), and others). A multidisciplinary approach provides better coping strategies and improves control over the disease, patient adherence to therapy, and quality of life. It also has a positive influence on family quality of life while at the same time making more efficient use of dermatology healthcare resources, reducing the economic burden on both patients and society.
Inflammatory Mediators of Endothelial Dysfunction
Authors: Dri Eirini , Lampas Evangelos , Lazaros George , Lazarou Emilia , Theofilis Panagiotis , Tsioufis Costas , Tousoulis Dimitris
Published: June 2023

Endothelial dysfunction (ED) is characterized by imbalanced vasodilation and vasoconstriction, elevated reactive oxygen species (ROS), and inflammatory factors, as well as deficiency of nitric oxide (NO) bioavailability. It has been reported that the maintenance of endothelial cell integrity serves a significant role in human health and disease due to the involvement of the endothelium in several processes, such as regulation of vascular tone, regulation of hemostasis and thrombosis, cell adhesion, smooth muscle cell proliferation, and vascular inflammation. Inflammatory modulators/biomarkers, such as IL-1α, IL-1β, IL-6, IL-12, IL-15, IL-18, and tumor necrosis factor α, or alternative anti-inflammatory cytokine IL-10, and adhesion molecules (ICAM-1, VCAM-1), involved in atherosclerosis progression have been shown to predict cardiovascular diseases. Furthermore, several signaling pathways, such as NLRP3 inflammasome, that are associated with the inflammatory response and the disrupted H2S bioavailability are postulated to be new indicators for endothelial cell inflammation and its associated endothelial dysfunction. In this review, we summarize the knowledge of a plethora of reviews, research articles, and clinical trials concerning the key inflammatory modulators and signaling pathways in atherosclerosis due to endothelial dysfunction.
Bioactive Phytoconstituents and Their Therapeutic Potentials in the Treatment of Haematological Cancers: A Review
Authors: Iweala Emeka J. , Oluwapelumi Adurosakin E. , Dania Omoremime E. , Ugbogu Eziuche Amadike
Published: June 2023

Haematological (blood) cancers are the cancers of the blood and lymphoid forming tissues which represents approximately 10% of all cancers. It has been reported that approximately 60% of all blood cancers are incurable. Despite substantial improvement in access to detection/diagnosis, chemotherapy and bone marrow transplantation, there is still high recurrence and unpredictable but clearly defined relapses indicating that effective therapies are still lacking. Over the past two decades, medicinal plants and their biologically active compounds are being used as potential remedies and alternative therapies for the treatment of cancer. This is due to their anti-oxidant, anti-inflammatory, anti-mutagenic, anti-angiogenic, anti-cancer activities and negligible side effects. These bioactive compounds have the capacity to reduce proliferation of haematological cancers via various mechanisms such as promoting apoptosis, transcription regulation, inhibition of signalling pathways, downregulating receptors and blocking cell cycle. This review study highlights the mechanistic and beneficial effects of nine bioactive compounds (quercetin, ursolic acid, fisetin, resveratrol, epigallocatechin gallate, curcumin, gambogic acid, butein and celastrol) as potential remedies for chemoprevention of haematological cancers. The study provides useful insights on the effectiveness of the use of bioactive compounds from plants for chemoprevention of haematological cancers.
Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge?
Authors: Bonanni Roberto , Cariati Ida , Marini Mario , Tarantino Umberto , Tancredi Virginia
Published: June 2023

Space colonization represents the most insidious challenge for mankind, as numerous obstacles affect the success of space missions. Specifically, the absence of gravitational forces leads to systemic physiological alterations, with particular emphasis on the musculoskeletal system. Indeed, astronauts exposed to spaceflight are known to report a significant impairment of bone microarchitecture and muscle mass, conditions clinically defined as osteoporosis and sarcopenia. In this context, space medicine assumes a crucial position, as the development of strategies to prevent and/or counteract weightlessness-induced alterations appears to be necessary. Furthermore, the opportunity to study the biological effects induced by weightlessness could provide valuable information regarding adaptations to spaceflight and suggest potential treatments that can preserve musculoskeletal health under microgravity conditions. Noteworthy, improving knowledge about the latest scientific findings in this field of research is crucial, as is thoroughly investigating the mechanisms underlying biological adaptations to microgravity and searching for innovative solutions to counter spaceflight-induced damage. Therefore, this narrative study review, performed using the MEDLINE and Google Scholar databases, aims to summarize the most recent evidence regarding the effects of real and simulated microgravity on the musculoskeletal system and to discuss the effectiveness of the main defence strategies used in both real and experimental settings.
Hydration of Phosphate Ion in Polarizable Water: Effect of Temperature and Concentration
Authors: Verma Sandeep , Pathak Arup Kumar
Published: June 2023

The hydration of phosphate ions, an essential component of many biological molecules, is studied using all-atom molecular dynamics (MD) simulation and quantum chemical methods. MD simulations are carried out by employing a mean-field polarizable water model. A good linear correlation between the self-diffusion coefficient and phosphate anion concentration is ascertained from the computed mean-square displacement (MSD) profiles. The HB dynamics of the hydration of the phosphate anion is evaluated from the time-dependent autocorrelation function CHB(t) and is determined to be slightly faster for the phosphate–anion system as compared to that of the water–water system at room temperature. The coordination number (CN) of the phosphate ion is found to be 15.9 at 298 K with 0.05 M phosphate ion concentration. The average CN is also calculated to be 15.6 for the same system by employing non-equilibrium MD simulation, namely, the well-tempered meta-dynamics method. A full geometry optimization of the PO43−·16H2O cluster is investigated at the ωB97X-D/aug-cc-pVTZ level of theory, and the hydration of the phosphate anion is observed to have both singly and doubly bonded anion–water hydrogen bonds and inter-water hydrogen bonds in a range between 0.169–0.201 nm and 0.192–0.215 nm, respectively. Modified Stokes–Einstein relation is used to calculate the conductivity of the phosphate ion and is found to be in good agreement with the experimentally observed value.
Investigation of the Static Performance of Hydrostatic Thrust Bearings Considering Non-Gaussian Surface Topography
Authors: Lu Huaiqing , Tian Zhuxin
Published: June 2023

The dynamic and static characteristics of hydrostatic thrust bearings are significantly affected by the bearing surface topography. Previous studies on hydrostatic thrust bearings have focused on Gaussian distribution models of bearing surface topography. However, based on actual measurements, the non-Gaussianity of the distribution characteristics of bearing surface topography is clear. To accurately characterize the non-Gaussian distribution of bearing surface topography, the traditional probability density function of Gaussian distribution was modified by introducing Edgeworth expansion. The non-Gaussian surface was then reflected by two parameters: kurtosis and skewness. This had an effect on the static characteristics of hydrostatic thrust bearings with both circumferential and radial surface topographies. The comparison between the Gaussian distribution results and those of the non-Gaussian model showed that errors between the two models could reach more than 10%. Therefore, it is important to take into account the non-Gaussianity of bearing surface when discussing static characteristics of hydrostatic thrust bearings considering the surface topography.
Influence of Cutting Parameters and Tool Geometry on Topography of Hard Turned Surfaces
Authors: Molnar Viktor
Published: June 2023

Three-dimensional topography measurement is a focus area of precision machining because it provides detailed information on the functional behavior of contacting surfaces. The purpose of this study is to analyze how the process parameters and the edge geometry of the cutting insert influence the topographical characteristics of hardened 16MnCr5 steel surfaces and to determine the favorable combinations of technology parameter values based on the analyzed topography parameters (Ssk, Sku, Sz, Sa, Sk, Spk, Svk). A research question is whether the analyzed parameters can be substituted by each other or not. A hard turning experiment was carried out based on a full factorial design of experiments, and the areas of the machined surfaces were scanned and analyzed by analysis of variance, regression analysis (response function), and correlation analysis. It was found that there are strong correlations between the topography parameters that allow the substitution of one with another; the main influencing cutting parameter is the feed rate for both insert types. The contributions of the study are the numerical information with regard to the correlations among the topography parameters, as well as the extent of the influence of cutting parameters.
Constrained Cost Fuzzy Control via Decentralized Design Approach for Nonlinear Descriptor Interconnected Systems
Authors: Chang Wen-Jer , Su Che-Lun , Ku Cheung-Chieh , Sun Chein-Chung
Published: June 2023

This paper proposes a decentralized robust constrained cost fuzzy controller (DRCCFC) design for nonlinear descriptor interconnected systems (DIS) with uncertainties. The considered nonlinear DIS is modeled using Takagi–Sugeno fuzzy model (T-S FM) with fuzzy rules and strong interconnections. To derive sufficient stability conditions, the quadratic Lyapunov function (QLF) and free-weighting function (FWF) are defined. In contrast to the existing control approaches, the proportional–derivative feedback (PDF) control is introduced in this paper. Using the PDF control techniques, the regular and causal problems of the system can be solved easily. Based on the PDF control technique and constrained cost control (CCC) function, a set of fuzzy controllers are designed to effectively control the Takagi–Sugeno descriptor interconnected systems (T-S DIS). Then, the proposed sufficient conditions for the T-S DIS are derived in the form of linear matrix inequalities using the Schur complement technique. Finally, two simulation examples are provided to demonstrate the validity of the proposed control scheme.
An Improved Unit Quaternion for Attitude Alignment and Inverse Kinematic Solution of the Robot Arm Wrist
Authors: Ahmed Abubaker , Ju Hehua , Yang Yang , Xu Hao
Published: June 2023

This paper introduces a new method for kinematic modeling of the robot arm by deriving a new elegant mathematical formula based on the axis vector with the tangent of the rotation angle. For this purpose, an innovative analytical quaternion is introduced through integration between Axis-Invariants and unit quaternion features named Ju-Gibbs quaternion, which expresses the body rotation with non-redundant parameters compared with the quaternions in literature. Two theorems based on the new form of the quaternion are developed and proved for the kinematic modeling of the robot arm. The first is attitude alignment, which is essential in multiaxial rotation systems. The second theorem for the wrist inverse kinematic (IK) solution is utilized to obtain the joint variables for the last joints of the end effector. In order to verify the effectiveness and accuracy of the proposed method, a numerical example and simulation of different structural configurations of robot and human arms are intensively studied. The novel quaternion provides a new tool for kinematic analysis and reduces the computational complexity of the kinematic solutions of the Robot-Arms wrist. Furthermore, the method laid a new foundation for the IKs of multi-axis systems based on Axis-Invariant and tangent quaternion.
Self-Similarity Principle and the General Theory of Fractal Elements: How to Fit a Random Curve with a Clearly Expressed Trend?
Authors: Nigmatullin Raoul R. , Chen YangQuan
Published: June 2023

The well-known power-law fractal element was determined to need several important revisions by the authors of this work. It is now possible to demonstrate that any scaling equation associated with a fractal element is actually K-fold degenerated and includes previously unknown but crucial adjustments. These new discoveries have the potential to significantly alter the preexisting theory and create new connections between it and its experimental support, particularly when it comes to measurements of the impedances of diverse metamaterials. It is now easy to demonstrate that any random curve with a clearly stated tendency in a specific range of scales is self-similar using the method involving reduction to three invariant points (Ymx, Ymn, and Ymin). This useful procedure indicates that the chosen random curve, even after being compressed a certain number of times, still resembles the original curve. Based on this common peculiarity, it is now possible to derive “a universal” fitting function that can be used in a variety of applied sciences, particularly those that deal with complex systems, to parametrize many initial curves when a model fitting function derived from a simple model is not present. This self-similarity principle-derived function demonstrates its effectiveness in data linked to photodiode noise and the smoothed integral curves produced from well-known transcendental numbers E and Pi, which are considered in the paper as an example.
An Ensemble Deep Learning Model for Provincial Load Forecasting Based on Reduced Dimensional Clustering and Decomposition Strategies
Authors: Wang Kaiyan , Du Haodong , Wang Jiao , Jia Rong , Zong Zhenyu
Published: June 2023

The accurate prediction of short-term load is crucial for the grid dispatching department in developing power generation plans, regulating unit output, and minimizing economic losses. However, due to the variability in customers’ electricity consumption behaviour and the randomness of load fluctuations, it is challenging to achieve high prediction accuracy. To address this issue, we propose an ensemble deep learning model that utilizes reduced dimensional clustering and decomposition strategies to mitigate large prediction errors caused by non-linearity and unsteadiness of load sequences. The proposed model consists of three steps: Firstly, the selected load features are dimensionally reduced using singular value decomposition (SVD), and the principal features are used for clustering different loads. Secondly, variable mode decomposition (VMD) is applied to decompose the total load of each class into intrinsic mode functions of different frequencies. Finally, an ensemble deep learning model is developed by combining the strengths of LSTM and CNN-GRU deep learning algorithms to achieve accurate load forecasting. To validate the effectiveness of our proposed model, we employ actual residential electricity load data from a province in northwest China. The results demonstrate that the proposed algorithm performs better than existing methods in terms of predictive accuracy.
Transfer of Quantum States and Stationary Quantum Correlations in a Hybrid Optomechanical Network
Authors: Molinares Hugo , He Bing , Eremeev Vitalie
Published: June 2023

We present a systematic study on the effects of dynamical transfer and steady-state synchronization of quantum states in a hybrid optomechanical network consisting of two cavities, which carry atoms inside and interact via a common moving mirror such as the mechanical oscillator. It is found that a high fidelity transfer of Schrödinger’s cat and squeezed states between two cavities modes is possible. On the other hand, we demonstrate the synchronization effect of the cavity modes in a steady squeezed state with its high fidelity realized by the mechanical oscillator that intermediates the generation, transfer and stabilization of the squeezing. In this framework, we also study the generation and evolution of bipartite and tripartite entanglement and find its connection to the effects of quantum state transfer and synchronization. Particularly, when the transfer occurs at the maximal fidelity, any entanglement is almost zero, so the different cavity modes are disentangled. However, these modes become entangled when the two bosonic modes are synchronized in a stationary squeezed state. The results provided by the current study may find applications in quantum information technologies, in addition to the setups for metrology, where squeezed states are essential.
Numerical Simulation of the Korteweg–de Vries Equation with Machine Learning
Authors: Williams Kristina O. F. , Akers Benjamin F.
Published: June 2023

A machine learning procedure is proposed to create numerical schemes for solutions of nonlinear wave equations on coarse grids. This method trains stencil weights of a discretization of the equation, with the truncation error of the scheme as the objective function for training. The method uses centered finite differences to initialize the optimization routine and a second-order implicit-explicit time solver as a framework. Symmetry conditions are enforced on the learned operator to ensure a stable method. The procedure is applied to the Korteweg–de Vries equation. It is observed to be more accurate than finite difference or spectral methods on coarse grids when the initial data is near enough to the training set.
D-Mannose Plus Saccharomyces boulardii to Prevent Urinary Tract Infections and Discomfort after Cystoscopy: A Single-Center Prospective Randomized Pilot Study
Authors: Quattrone Carmelo , Manfredi Celeste , Napolitano Luigi , Ferraro Angelo , Distefano Concetta , Di Girolamo Antonio , Sciorio Carmine , Imperatore Vittorio , Bottone Francesco , La Rocca Roberto , Arcaniolo Davide , De Sio Marco , Spirito Lorenzo
Published: June 2023

Background and Objectives: Patients undergoing cystoscopy can experience discomfort or pain during the procedure. In some cases, a urinary tract infection (UTI) with storage lower urinary tract symptoms (LUTS) may occur in the days following the procedure. This study aimed to assess the efficacy of D-mannose plus Saccharomyces boulardii in the prevention of UTIs and discomfort in patients undergoing cystoscopy. Materials and Methods: A single-center prospective randomized pilot study was conducted between April 2019 and June 2020. Patients undergoing cystoscopy for suspected bladder cancer (BCa) or in the follow-up for BCa were enrolled. Patients were randomized into two groups: D-Mannose plus Saccharomyces boulardii (Group A) vs. no treatment (Group B). A urine culture was prescribed regardless of symptoms 7 days before and 7 days after cystoscopy. The International Prostatic Symptoms Score (IPSS), 0–10 numeric rating scale (NRS) for local pain/discomfort, and EORTC Core Quality of Life questionnaire (EORTC QLQ-C30) were administered before cystoscopy and 7 days after. Results: A total of 32 patients (16 per group) were enrolled. No urine culture was positive in Group A 7 days after cystoscopy, while 3 patients (18.8%) in Group B had a positive control urine culture (p = 0.044). All patients with positive control urine culture reported the onset or worsening of urinary symptoms, excluding the diagnosis of asymptomatic bacteriuria. At 7 days after cystoscopy, the median IPSS of Group A was significantly lower than that of Group B (10.5 vs. 16.5 points; p = 0.021), and at 7 days, the median NRS for local discomfort/pain of Group A was significantly lower than that for Group B (1.5 vs. 4.0 points; p = 0.012). No statistically significant difference (p > 0.05) in the median IPSS-QoL and EORTC QLQ-C30 was found between groups. Conclusions: D-Mannose plus Saccharomyces boulardii administered after cystoscopy seem to significantly reduce the incidence of UTI, the severity of LUTS, and the intensity of local discomfort.
Influence of Intraoperative Nociception during Hip or Knee Arthroplasty with Supplementary Regional Anaesthesia on Postoperative Pain and Opioid Consumption
Authors: Neumann Claudia , Gehlen Lena , Weinhold Leonie , Straßberger-Nerschbach Nadine , Soehle Martin , Kornilov Evgeniya , Thudium Marcus
Published: June 2023

Background and Objectives: Early postoperative mobilization is central for postoperative outcomes after lower extremity joint replacement surgery. By providing adequate pain control, regional anaesthesia plays an important role for postoperative mobilization. It was the objective of this study to investigate the use of the nociception level index (NOL) to determine the effect of regional anaesthesia in hip or knee arthroplasty patients undergoing general anaesthesia with additional peripheral nerve block. Materials and Methods: Patients received general anaesthesia, and continuous NOL monitoring was established before anaesthesia induction. Depending on the type of surgery, regional anaesthesia was performed with a Fascia Iliaca Block or an Adductor Canal Block. Results: For the final analysis, 35 patients remained, 18 with hip and 17 with knee arthroplasty. We found no significant difference in postoperative pain between hip or knee arthroplasty groups. NOL increase at the time of skin incision was the only parameter associated with postoperative pain measured using a numerical rating scale (NRS > 3) after 24 h in movement (−12.3 vs. +119%, p = 0.005). There was no association with intraoperative NOL values and postoperative opioid consumption, nor was there an association between secondary parameters (bispectral index, heart rate) and postoperative pain levels. Conclusions: Intraoperative NOL changes may indicate regional anaesthesia effectiveness and could be associated with postoperative pain levels. This remains to be confirmed in a larger study.
Association of Coffee and Tea Intake with Bone Mineral Density and Hip Fracture: A Meta-Analysis
Authors: Chen Chun-Ching , Shen Yu-Ming , Li Siou-Bi , Huang Shu-Wei , Kuo Yi-Jie , Chen Yu-Pin
Published: June 2023

Background and Objectives: Osteoporosis is characterized by low bone mass and high bone fragility. Findings regarding the association of coffee and tea intake with osteoporosis have been inconsistent. We conducted this meta-analysis to investigate whether coffee and tea intake is associated with low bone mineral density (BMD) and high hip fracture risk. Materials and Methods: PubMed, MEDLINE, and Embase were searched for relevant studies published before 2022. Studies on the effects of coffee/tea intake on hip fracture/BMD were included in our meta-analysis, whereas those focusing on specific disease groups and those with no relevant coffee/tea intake data were excluded. We assessed mean difference (MD; for BMD) and pooled hazard ratio (HR; for hip fracture) values with 95% confidence interval (CI) values. The cohort was divided into high- and low-intake groups considering the thresholds of 1 and 2 cups/day for tea and coffee, respectively. Results: Our meta-analysis included 20 studies comprising 508,312 individuals. The pooled MD was 0.020 for coffee (95% CI, −0.003 to 0.044) and 0.039 for tea (95% CI, −0.012 to 0.09), whereas the pooled HR was 1.008 for coffee (95% CI, 0.760 to 1.337) and 0.93 for tea (95% CI, 0.84 to 1.03). Conclusions: Our meta-analysis results suggest that daily coffee or tea consumption is not associated with BMD or hip fracture risk.