bluuebunny/crossref_metadata_2025 huggingface dataset:
Atypical Maisonneuve’s Fracture: A Case Report
Authors: Rachman Alwi , Dradjat Respati Suryanto
Published: October 2020

Abstract: A Maisonneuve’s Fracture is a fracture of proximal third fibula associated with a disruption of the distal tibiofibular syndesmosis, the interosseous membrane and associated injuries (eg, fracture of the medial malleolus, fracture of the posterior malleolus, and rupture of the deltoid ligament). The mechanism for the fracture is an external rotation force to the ankle with transmission of the force through the interosseous membrane which causes a proximal fibular fracture.In a very rare form, we can found an unusual pattern of the level of the involved fibula, such as middle third of fibula. A 19 year old male  presented to us with pain and swelling of his left ankle after felt while playing futsal. Physical examination showed deformity, swelling and tenderness on his left ankle. Range of motion was decreased. On imaging, plain radiographs of left ankle showed dislocation of the ankle, with disruption of syndesmotic and fracture comminutive middle third of fibula. We performed operation which are consists of three procedures; closed reduction, percutaneous fixation of syndesmotic by using a single transfixing screw, and plate-screw for the fibula. Normal range of motion is achieved well after 8 weeks, without pain on full weightbearing. The pattern of the fracture-dislocation of the ankle discussed is very rare. The mechanism of the injury is a twisting motion of the upperbody inward, while the foot is planted, resulting a more higher energy impacted to the ankle and fibula. We performed closed reduction easily by reverse the mechanism of injury. Keywords: Maisonneuve’s Fracture, distal tibiofibular syndesmosis, interosseous membrane, rupture of the deltoid ligament
Concomitant Distal Radioulnar Joint Disruption in Distal End Radius Fracture Cases Admitted to Emergency Ward Hasan Sadikin Hospital January 2013 – December 2015
Authors: Pinandita Tody , Herman Herry , Ismiarto Yoyos Dias
Published: October 2020

Abstract: The distal end radius and ulna is an integral part of the wrist joint and preservation of its normal anatomy is essential for the mobility of the wrist. The most common cause of residual wrist disability after distal end radius fractures is the disruption of distal radioulnar joint (DRUJ). Early recognition and management in the acute stage aim at the anatomic reconstruction of the DRUJ in an effort to reduce incidence of chronic pain and loss of wrist motion. The purpose of this study is to identify the prevalence of accompanying DRUJ in distal end radius fracture cases, highlighting its significance in occurance. This was a retrospective study with an analytic descriptive method and data from January 2013-December 2015 taken from medical records of Dr. Hasan Sadikin Hospital. From research, we found 74 cases of distal end radius fracture. The most common injured wrist were dominant hand as 46 cases (62,2%), and non-dominant hand as 28 cases (37,8%). From all data, DRUJ disruption were marked as 37 cases (50%). Extraarticular fracture with concomitant DRUJ disruption were marked in 3 cases (8,1%) and in intraarticular involvement were 34 cases (91,9 %). From this study, we can conclude that half of the distal end radius fracture cases, especially intraarticular, were accompanied by DRUJ  disruption. This should be an issue to be concerned by the physician when evaluating distal end radius fracture cases and to perform proper treatment.
Dengue Hemorrhagic Fever: Past, Present, and Future
Authors: Budianto Rahmad , Budiarti Niniek
Published: October 2020

Abstract: Dengue viral infection is a global disease with a spectrum of clinical manifestations mild fever to severe disease both dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). DHF is severe form of dengue fever (DF), which can be life-threatening. Climate changes is not the only factor that affects dengue transmission, but also globalization changes includes travel and trade. The pathogenesis of dengue infection is complex. The mechanism involved antibody-dependent enhancement, NS1 and its antibodies, T cells, and DENV genomics. There are several novel methods to detect the presence of dengue virus in the body of infected patients. These include ELISA-specific IgM and IgG detection, detection of monoclonal antibodies and mosquito cell strains, and PCR reverse transcriptase detection. Several trials found novel methods to predict the severity of dengue hemorrhagic fever earlier. These include platelet count, Aspartate aminotransferase / platelet count index (APRI) Index, serum chymase level, serum cytokine/chemokine profile, Tropomyosin-alpha 1 (TPM 1), Reticulocyte Production Index (RPI), and Immature Platelet Fraction (IPF). Several pharmacological therapies are known to have potential antidengue effect. Some of these are corticosteroids, antimalarial drugs, doxycycline and tetracycline, anticholesterol drugs, IVIG, celgosivir, balapiravir, pentoxifylline and calcium supplementation. Some natural products are known to have activity against Aedes aegypti through antiviral mechanisms, larvacidal activity, mosquitocidal, and mosquito repellants. It can be developed as the latest therapy of dengue hemorrhagic fever on the future. The objective of this paper is to provide new insight about the development of dengue hemorrhagic fever related to the history of its distribution, pathogenesis, and the latest developments related to detection methods, severity prediction methods, and the management of dengue hemorrhagic fever on the future. Keywords: globalization changes, novel detection methods, severity prediction methods, latest development in DHF therapy
The Influence of Giving Tempe Flour Toward the Amount and Morphology of White Male Rat (Rattus norvegicus) Erythrocytes Wistar Strain was Affected by Cigarette Smoke
Authors: Harsa I Made Subhawa
Published: October 2020

Abstract: Cigarette smoke was one of free radicals source for the body. Free radical contain in cigarette smoke were hydroxide radicals (•OH). Hydroxide radicals would cause erythrocytes damage. Antioxidants were substances that can prevent free radicals. Now, natural antioxidants source has developed, one of that is tempe, because of it contained antioxidants substances such as carotene, Vitamin E, isoflavon, and factor II antioxidants. This resource was for knowing the influence of giving tempe flour toward the amount and morphology of white male rat (Rattus norvegicus) erythrocytes wistar strain was affected by cigarette smoke. A pure experiment which was used the post test only-control group design method. Sample of the resource was white male rat wistar strain aged of 3-4 month as much 30 rats by the weight around 180-220 gram. The samples divided into 3 groups that were control group (K1), treatment group 1 (K2), and treatment group 2 (K3), each group consists of 10 rats. Control group was not given a special treatment, it only got a standard feed, treatment group 1 got special treatment and it was affected by cigarette smoke, furthermore, treatment group 2 got standard feed, it was affected by cigarette smoke and tempe. Analysis of data used one way anova experiment. The test showed the significance P-value = 0,036 that was <α (0,05). The result showed that there was the influence of giving tempe flour toward the amount and morphology of white male rat (Rattus norvegicus) erythrocytes wistar strain was affected by cigarette smoke. Keywords: cigarette smoke, free radicals, erythrocytes, antioxidants, tempe
Effectiveness Test of Papaya Leaves Extract (Carica papaya L.) as Antihelmintics of Ascaridia galli Worm
Authors: Rahmasari Farindira Vesti , Wibowo Fikri Adhi
Published: October 2020

Abstract: Introduction: Soil-transmitted helminth is a group of nematoda worm parasite that causes infection in human because the egg is swallowed or direct contact with the larva. More than two billion people in the world had infection for at least one spesies of the nematoda worm, especially A. lumbricoides, T. trichiura and A. duodenale. Ascaridia galli is a worm parasite that classifeid in nematoda fillum. Ascaridia worm has the same genus with Ascaris Lumbricoides that infect human. Antihelmintic is a drug that can eradicate the worm in human and animal body. There is a side effect in the antihelmintic drug like Mebendazole so another alternative like organical antihelmintic from papaya leaves (Carica papaya L.) is needed. This research is a true experiment with post test control group design. The subjects were 160 Ascaridia galli worm which were divided into 5 worms in each test group (5%, 10%, 20%, 40%, 60%, dan 80%), positive control group (Pirantel pamoat 0,5%) and negative control  repeated as many as 4 replications. The treatment was given for 12 hours and observed the number of dead worm at each hour. Data were analyzed by statistical test of Kruskal Wallis Test and followed by post-hoc Mann-Whitney Test. It is also tested the probit analysis to determine lethal time (LT50 and LT90) and lethal concentration (LC50 and LC90).There was a significant difference (p <0.05) between all test concentrations except between 5% to negative control. It could be evidenced that the papaya leaves (Carica papaya L.) has an antihelmintic effect on Ascaridia gall. The results of probit analysis for LC50 and LC90 were 6,182% and 14,422% respectively. It is known that LT50 at concentrations of 25%, 10%, 20%, 40%, 60%, and 80% respectively were 11,84 hours, 10,536 hours, 9,328 hours, 6,794 hours, 5,472 hours and 2,892 hours. While the LT90 at concentrations of 25%, 10%, 20%, 40%, 60%, and 80% respectively were 13,608 hours, 12,303 hours, 11,095 hours, 8,562 hours, 7,24 hours, dan 4,66 hours.The ethanol extract of Papaya leaves Carica papaya was shown to have an antihelmentic effect on Ascaridia galli effectifically at concentrations of 10%, 20%, 40%, 60% dan 80%. The values of LC50 and LT50 at highest concentration (80%) at the end of the observations are 6,182% and 2,892 hours respectively. The values of LC50 and LT90 at the highest concentration (80%) were 14,442% dan 4,66 hours respectively. The higher concentration of ethanol extract of papaya leaves Carica papaya the greater the effectiveness in killing Ascaridia galli. Keywords: Antihelmintic – Ascaridia galli – Carica papaya L. – Lethal Concentration – Lethal Time
Correlation between Knowledge and the Adherence to Take Antihypertensive Medication for Elderly Hypertensive Patients in Krian Public Health Center Sidoarjo Regency
Authors: Sahadewa Sukma , Dwipa Kadek , Yoga Gede Abi , Pertiwi Mandasari Dwi
Published: October 2020

Abstract: Hypertension is a condition of elevated abnormal arterial blood pressure that lasts persistently. Some knowledge that should be known by hypertensive patients are such as the meaning of hypertension, the cause of hypertension, the symptoms that come along, and the importance of regular and long term treatment, also knowing the dangers posed if not taking the medication. This study aims to determine the correlation between knowledge and adherence to taking antihypertensive medication in elderly hypertensive patients at the Krian Public Health Center, Sidoarjo Regency. In this study, the population was elderly hypertensive patients who examined themselves or only took control to take medication at the Elderly Polyclinic of Krian Public Health Center in Sidoarjo Regency with 332 populations with 75 samples taken. The result of this research was obtained sig. value = 0,000 (<0,05). This study used the Spearman Correlation statistical test in analyzing the data. From the results of this study it was concluded that there was a relationship between knowledge and adherence to taking antihypertensive medication in elderly hypertensive patients at the Krian Public Health Center, Krian District, this was proved by the acquisition of sig values. = 0,000 (<0.05). Keywords: knowledge, the adherence of taking medication, hypertension
The Influence of Parents Knowledge and Health Care Access to the Identification of Children with Hearing Impairment
Authors: Widuri Asti , Arifianto Muhammad Pringgo
Published: October 2020

Abstract: Early identification and access to quality habilitative services designed for children with hearing loss is the key to developing language and communication skills commensurate with the children’s cognitive abilities. Early identification will provide the opportunity for improved outcomes for thousands of children with hearing loss. Objective: To review the role of parents knowledge and health care Access to the identification of children with hearing impairment. The study design was cross-sectional, with the sample were 45 parents of children at SLB – B Karnnamanohara Yogyakarta at the nursery-child and play group. Interviewer administered a questionnaire to the parents, for evaluations of their knowledge about deaf children and health care access. After obtained the data from the each variable, then test with chi-square statistic. The significant result shown at parental knowledge (p=0,028) and health care access (p= 0,02). This means that there were significant differences between parental knowledge about speech and language development and health care access to early detection of deafness in children. Parents knowledge and health care access influenced to the identification of children with hearing impairment. Keywords: Parental knowledge, speech and language development, early detection, children with hearing loss, health care access
Clinical Analysis of Channa micropeltes for Treating Wound of Diabetes Mellitus
Authors: Apriasari Maharani Laillyza , Syahadati Marina Arum , Carabelly Amy Nindia
Published: October 2020

Abstract: Toman fish contains albumin and omega-6 fatty acid that are instrumental in the healing process of diabetes mellitus (DM) wound. People with DM usually have a prolonged wound healing process. Albumin controls the osmotic pressure, the development of granulation tissue, gives the energy to re-epithelialisation process and collagen base material. Omega-6 fatty acid interrupts phagocytosis induced by neutrophil cells. It increases the action of machropage cell, so that Toman fish can be used as an alternative in accelerating the DM wound healing process. The purpose of this research is to prove the effect of Toman fish extract at 16 mL/ KgBW rat dosage per oral on wound length and contraction on the back of wistar rat (Rattus novergiucs) with DM for 14 days. It was the experimental with a posttest only with control group design  used 12 wistar rat that were divided into 3 groups; the group of Toman fish extract with dose 16 mL/ Kg BW rat, positive control group using Haruan extract with dose 13,54 mL/ Kg BW rat and negative control group using Comfeed BR2 feed. One-way ANOVA test result for wound length and contraction (p= 0,000). The result Post-hoc Least Significant Difference test for wound length and contraction shows that there are significant differences between the group of Toman fish extract and Haruan fish extract (p= 0,000). There is also significant difference between the group of Toman fish extract and Comfeed BR2 feed (p= 0,000). There is no significant difference between the group of Haruan fish extract and Comfeed BR2 feed (p= 0,930). The research concluded that Toman fish extract at 16 mL/ Kg BW rat dosage affects the length and contraction of diabetic mellitus wound. Keywords: Channa micropeltes, clinical analysis, diabetes mellitus, wound
Correlation of Ankle - Brachial Index (ABI) and Low - Density Lipoprotein (LDL) with Diabetic Foot Severity Degree
Authors: Maulana Muhammad Ghaly , Fajari Nanang Miftah , Pratiwi Dewi Indah Noviana
Published: October 2020

Abstract: Diabetic foot is a complication of diabetes mellitus which is characterized by ulceration in the legs. The severity of the diabetic foot can be determined by the Wagner-Meggit system which in this study uses 5 categories namely degrees 1 - 5 degrees. ABI (Ankle-Brachial Index) is an evaluation of peripheral arterial disease in diabetic foot patients. LDL is the main factor of atherosclerosis which causes macrovascular disorders in diabetic foot. The purpose of this study was to determine the correlation between ABI and LDL on the severity of diabetic foot based on the Wagner-Meggit classification. The method used is observational analytic with cross sectional approach. A total of 35 samples were obtained by consecutive sampling. Data analysis was performed using the Spearman test and logistic regression. A significant correlation was obtained between ABI and the severity of diabetic foot (p = 0.06; r = -0.424), there was no correlation between LDL and the severity of diabetic foot (p = 0.09; r = -0.395). The results of logistic regression analysis found no correlation between ABI (p = 0.163; OR = 0.008) and LDL (p = 0.69; OR = 0.984) with the severity of the diabetic foot. Obtained Negelkerke R Square value of 0.095. Keywords: Diabetic foot, ABI, LDL, Wagner-Meggit classification
Correlation between Dimension of Fingers Phalannx Proximal and Height in the Age of 18-45 Years Old
Authors: Hafizah Talitha Lailatul , Afandi Dedi , Widyaningsih Chunin , Siregar Fajri Marindra
Published: October 2020

Abstract: Height is one of the data needed in forensic identification process of a remains that is difficult to identify in an incomplete condition. Height estimation can be determined by the proximal phalanx of the fingers which are long bones. This study was conducted on 113 men and 125 women in several places in Riau Province age 18 - 45 years. The height and dimensions of the proximal phalanx of the fingers are measured to get the correlation and linear regression formula for height. There are 6 dimensions measured on the fingers of the left and right hand. The study design was cross sectional. The statistical test used is Pearson correlation to determine the correlation between dimensions of the proximal phalanx on fingers with height and linear regression analysis for height regression formula. The results show that some dimensions of the proximal phalanx of the fingers are significantly correlated with height. Keywords: identification, height, dimensions of the proximal phalanx bone fingers, correlation, regression formula.
Bacteria Sensitivity Pattern of Caesarean Section Wound on Selected Antibiotics in Ulin General Hospital Banjarmasin
Authors: Rafiani Nurhafizah , Aditya Renny , Muthmainah Noor
Published: October 2020

Abstract: A cesarean delivery increases the risk of wound infection it should be prevented by using antibiotics. This study was to determine the pattern of bacterial sensitivity in surgical wounds of cesarean section patients for selected antibiotics, i.e ceftriaxone, cefixime, sulbactam ampicillin, ciprofloxacin, clindamycin and gentamicin.This observational study was conducted at the Ulin Public Hospital in Banjarmasin from July to September 2019. Using a cross sectional approach Samples of bacteria were identidied from 36 that were pusposively sampled, i.e., Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli. Antibiotic sensitivity test showed that Staphylococcus aureus was sensitive against gentamicin (100%),whereas Staphylococcus epidermidis and Escherichia coli. Were intermediately sensitive towards gentamicin (62.5%) and ceftriaxone (80%) Keywords: Antibiotic susceptibility, caesarean section, surgical wound
Mesentrial Cyst Lymphangioma in 3-Year-Old Girls: A Case Report
Authors: Noor Hafni Zuchra , Agustriani Nunik
Published: October 2020

Abstract: Mesenterial cysts are rare tumors, incidence 1: 100,000-200,000. We report the case and the treatment. Case report, 3-year-old woman with complaints of a lump in the abdomen. Complaints in the last 1 year ago, sometimes she felt pain, physical examination showed a lump of cystic impression with a size of ± 5x10 cm in the epigastric region, mobile, firm boundary. It can be diagnosed with a suspected intra-abdominal tumor with a mesenterial cyst, differential diagnosis of teratoma. Surgery was performed and a mass was found in retroperitoneal with a size of ± 20x5 cm up to the pelvic cavity, cystic and mobile, the mass could not be taken at all, we decided to do marsupialization, and left kidney is not visible. Postoperative diagnosis is retroperitoneal (type IV) mesenterial cyst lymphangioma with agenesis ren sinistra. Mesenterial cyst Lymphangioma is a tumor that is very rarely found and is benign. For a good prognosis, it depends on the type and therapy that is performed. Keywords: Mesenterial cyst lymphangioma, a tumor in children, mesenterial tumor
Potential of Pectin in Lemon’s and Bali Orange’s Peel as Antidislipidemia and Antioxidant in Hypercholesterolemia Rats (Rattus novergicus)
Authors: Indahsari Noer Kumala , Aristanto Aristanto , Rio Rio
Published: October 2020

Abstract: Dyslipidemia is a lipid metabolism disorder characterized by an increase or decrease in plasma lipid fractions. Lemon’s and Bali Orange’s Peels, which are usually discarded, can be used because they contain pectin compounds. The presence of pectin compounds contained in the Lemon and Bali oranges Peels is expected to potentially reduce the risk factors for cardiovascular disease. This research method was conducted with pure experimental, namely One Group Pre-Test-Post Test Design. With 5 groups of white rats, the first was a positive control group which was only given normal food, the second was a negative control group which was given hypercholesterolemia and the third group was the treatment group who were given Lemon orange peel extract 10%, Bali orange peels extract 10% and a mixture Lemon and Bali orange peel extract 10%. The results of this study were obtained that the administration of Lemon orange peel ethanol extract and Balinese orange peel can effectively reduce total cholesterol levels, from 181.87 mg / dL to 69.29 mg / dL, down around 61.91%, HDL levels are almost the same, levels LDL decreased from 56.76 mg / dL to 45.71 mg / dl, meaning around 19.47%, Triglyceride levels decreased from 192.50 mg / dL to 77.83 mg / dL, which was around 59.57%, levels MDA decreased from 8.19 mg / dL to 6.37 mg / dL, which is down about 22.22% in white rats (Rattus novergicus) made hypercholesteroalmia. Ethanol extract of Lemon and Bali orangse peels containing pectin can effectively reduce total cholesterol, LDL, HDL, Trygliceryde, and Malodialdehyd (MDA) Levels Keywords: Hypercholesterolamia, Pectin, Antidislipidemia, and Antioxidant
Molecular Docking Studies of α-Pyrone Derivatives Isolated from Alternaria phragmospora as CRM1 Inhibitors
Authors: Metwaly Ahmed , Eissa Ibrahim , Mostafa Ahmad
Published: October 2020

Some α-Pyrone derivatives isolated from Alternaria phragmospora fungus showed promising anti leukemic activities, while others were inactive. CRM1/XPO1 (chromosome region maintenance 1 protein, also called exportin1 or PO1 in humans) has been chosen as a target for antileukemic molecular docking study for those compounds to understand their modes of interaction and structure activity relationships. The results showed that two (2 and 4), out of six, natural α-Pyrone derivatives exhibited well-established interactions with the amino acids of the receptor, which was in agreement with the experimental anti-leukemic results of these compounds. Moreover, twenty hypothetical chemically modified α-Pyrone derivatives (7-27) have been designed. Compounds 7, 8, 22 and 24 showed more efficient docking properties than the previously considered natural compounds.
Reading between the Genetic Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes
Authors: Akil Ammira , Ali Laila , Yassin Esraa , Fakhro Khalid A. , Jeya Sujitha , Al-Kurbi Alya
Published: October 2020

Type 1 diabetes (T1D) is an autoimmune condition where the body’s immune cells destroy their insulin-producing pancreatic beta-cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However, failure to accurately mimic intrinsic glucose regulation results in glucose fluctuations and long-term complications impacting key organs such as the heart, kidneys, and/or the eyes. It is well-established that genetic and environmental factors contribute to the initiation and progression of type 1 diabetes, but recent studies show that epigenetic modifications are also important. Here, we discuss key epigenetic modifications associated with type 1 diabetes pathogenesis and discuss how recent research is finding ways to harness epigenetic mechanisms to prevent, reverse, or manage type 1 diabetes.
Cognition Enhancing Effect of Rosemary Plant (Rosmarinus officinalis, L) in Preclinical Studies: A Systematic Review and Meta-Analysis
Authors: Mohamed Hussain Shalam , Syeda Ayesha Farhana , Alshammari Mohammad , Alnasser Sulaiman , Alenzi Naif , Alanazi Samyah , Krishnadas Nandakumar
Published: October 2020

Background: Patients with mild cognitive impairment end up progressing to Alzheimer’s disease (AD) leading to straining burden on public health. R. officinalis long been known as the herb of remembrance and can be a potential cognition enhancer for AD. The aims of the review were to summarize the qualitative and quantitative aspects of R.O and its active constituents in enhancing the cognition. MATERIALS AND METHOD Google scholar and PubMed structured search to find relevant studies that assessed the effect of R.O extract or any of its active constituents on cognitive performance in animals. Data extraction: Following information from each included study was extracted: (1) article information (2) characteristics of study animals (3) type of intervention; type, dose, duration, and frequency of administration of R.O (4) type of outcome measure. Data synthesis: Data were analyzed using Review Manager (RevMan 5.3, 2014] and meta-analysis was performed for the outcome measures on all relevant tasks within the included papers by computing the standardized mean difference ps. RESULTS. 23 studies for qualitative and fifteen for meta-analysis were selected. From fifteen included papers, 22 studies with 35 comparisons were meta-analyzed. Effect sizes for intact animals and impaired animals respectively was (mean g and 95% CI 1.19 [0.74, 1.64; 0.57 [0.19,0.96]. The R. officinalis had positive effect on both groups of animals. The subgroup analyses exhibited substantial unexplained heterogeneity between studies. Mechanisms of R.O was anticholinesterase, procholinergic, antioxidant, anti-amyloid, neuroprotective and anti-inflammatory agent CONCLUSIONS: R.O improves cognitive function. Limitations: Considerable heterogeneity between studies.
Screening of Cognitive Changes in Adults with Intellectual Disabilities: A Systematic Review
Authors: Paiva Andreia F. , Nolan Adam , Thumser Charlotte , Santos Flavia H.
Published: October 2020

Abstract: Background and Aims: Screening and assessment of cognitive changes in adults with Intellectual Disabilities, mainly Down Syndrome (DS), is crucial to offer appropriate services to their needs. We present a systematic review of the existing instruments assessing dementia, aiming to support researchers and clinicians’ best practice. Methods: Searches were carried out in the databases Web of Science; PubMed; PsycINFO in March 2019 and updated in May 2020. Studies were selected and examined if they: (1) focused on assessing age-related cognitive changes in person with ID; (2) included adults and/or older adults; (3) included scales and batteries for cognitive assessment. Results: Forty-eight cross-sectional studies and twenty-six longitudinal studies were selected representing a total sample of 5,851 participants (4,089 DS and 1,801 with other ID). In those studies, we found 38 scales, questionnaires, and inventories, and 13 batteries for assessing cognitive and behavioural changes in adults with DS and other ID. Conclusion: The most used instrument completed by an informant or carer was the Dementia Questionnaire for Learning Disabilities (DLD), and its previous versions. We discuss the strengths and limitations of the instruments and outline recommendations for future use.
Mathematical Modelling in Prediction of Novel CoronaVirus (COVID-19) Transmission Dynamics
Authors: Uddin Md. Sharif , Nasseef Md. Taufiq , Mahmud Mufti , AlArjani Ali
Published: October 2020

Human civilizations are under enormous threats due to the outbreak of novel coronavirus (COVID-19) originated from Wuhan, China. The asymptomatic carriers are the potential spreads of this novel virus. Since, guaranteed antiviral treatments have not been available in the market so far, it is really challenging to fight against this contagious disease. To save the living mankind, it is urgent to know more about how the virus transmits itself from one to another quite rapidly and how we can predict future infections. Scientists and Researchers are working hard in investigating to understand its high infection rate and transmission process. One possible way to know is to use our existing COVID-19 infection data and prepare a useful model to predict the future trend. Mathematical modelling is very useful to understand the basic principle of COVID-19 transmission and provide necessary guidelines for future prediction. Here, we have reviewed 9 distinct commonly used models based on Mathematical implementations for COVID-19 transmission and dig into the deep head to head comparison of each model. Finally, we have discussed interesting key behaviour of each model, relevant upcoming important issues, challenges and future directions.
Design and Implementation of a Control Method for GaN-based Totem-Pole Boost-type PFC Rectifier in Energy Storage Systems
Authors: Do Nguyen-Nghia , Huang Bing-Siang , Nguyen Nhat-Truong , Nguyen Tan-Tung , Wu Jian-Hong , Liu Yu-Chen , Chiu Huang-Jen
Published: October 2020

With the unceasing advancement in wide-bandgap (WBG) semiconductor technology, the minimal reverse-recovery charge Qrr and other more powerful natures of WBG transistors enable totem-pole bridgeless PFC to become a dominant solution for energy storage systems (ESS). This paper focuses on design and implementation of a control structure for a totem-pole boost PFC with newfangled enhancement-mode Gallium Nitride (eGaN) FETs, not only to simplify the control implementation, but also to achieve high power quality and efficiency. The converter is designed to convert a 90-264-VAC input to a 385-VDC output for a 2.6-kW output power. Lastly, to validate the methodology, an experimental prototype is characterized and fabricated. The uttermost efficiency at 230 VAC attains 99.14%. The lowest total harmonic distortion in the current (ITHD) at high line condition (230 V) reaches 1.52% while the power factor gains 0.9985.
How to Understand Cells Well Enough to Predict Evolution: Polarity Establishment in Budding Yeast as a Case Study
Authors: Daalman Werner , Sweep Els , Laan Liedewij
Published: October 2020

A bottom-up route towards predicting evolution relies on deep understanding of the complex network proteins form inside cells. In a rapidly expanding panorama of experimental possibilities, the most difficult question is how to conceptually approach the disentangling of such complex networks. These can exhibit varying degrees of hierarchy and modularity, which obfuscate certain protein functions that may prove pivotal for adaptation. Using the well-established polarity network in budding yeast as a case study, we first organize current literature to highlight protein entrenchments inside polarity. Following three examples, we see how alternating between experimental novelties and subsequent emerging design strategies can construct a layered understanding, potent enough to reveal evolutionary targets. We show that if you want to understand a cell’s evolutionary capacity, such as possible future evolutionary paths, seemingly unimportant proteins need to be mapped and studied. Finally, we generalize this research structure to be applicable to other systems of interest.
Enhancement Magneto-optic Properties of Radio-Frequency-Magnetron-sputtered Bi-containing Ferrite Garnet-Type Thin-films using Oxygen plasma treatment and metal-oxide protective layers
Authors: Kotov V. A. , Alam Mohammad Nur-E , Vasiliev Mikhail , Balabanov D. E. , Burkov V. I. , Alameh Kamal
Published: October 2020

Magneto-optic (MO) imaging and sensing are at present the most developed practical applications of thin-film MO garnet materials. However, future component and system-level sensors and imagers technology improvements are still necessary in order to improve sensitivity for a range of established and also the forward-looking applications. These improvements are expected to originate from new material system development. We propose a set of technological modifications for the RF-magnetron sputtering deposition and crystallization annealing of magneto-optic bismuth-substituted iron-garnet films and investigate the improved material properties. Results show that standard crystallization annealing for the as-deposited ultrathin (sputtered 10 nm thick, amorphous phase) films resulted in more than a factor of two loss in the magneto-optical activity of the films in visible spectral region, compared to the liquid-phase grown epitaxial films. Results also show that an additional 10 nm-thick metal-oxide (Bi2O3) protective layer above the amorphous film results in ~2.7 times increase in the magneto-optical quality of crystallized iron-garnet films. On the other hand, the effects of post-deposition oxygen (O2) plasma treatment on the magneto-optical (MO) properties of Bismuth substituted iron garnet thin films material is investigated. Results show that, in the visible part of the electromagnetic spectrum (at 532 nm), the O2 treated (up to 3 minutes) garnet films retain higher specific Faraday rotation and figure of merit than those of non-treated garnet films.
Use of High Resolution Unmanned Aerial Systems Imagery and Machine Learning to Evaluate Grain Sorghum Tolerance to Mesotrione
Authors: Barnhart Isaac , Chauhaudri Sushila , Pandian Balaji Aravindhan , Prasad P.V. Vara , Ciampitti Ignacio A. , Jugulam Mithila
Published: October 2020

Manual evaluation of crop injury to herbicides is time-consuming. Unmanned aircraft systems (UAS) and high-resolution multispectral sensors and machine learning classification techniques have the potential to save time and improve precision in the evaluation of herbicide injury in crops, including grain sorghum (Sorghum bicolor L. Moench). The objectives of this research were to (1) evaluate three supervised classification algorithms (support vector machine, maximum likelihood, and random forest) for categorizing high-resolution UAS imagery to aid in data extraction and (2) evaluate the use of vegetative indices (VIs) collected from UAV imagery as an alternative to traditional methods of visual herbicide injury assessment in mesotrione-tolerant grain sorghum breeding trials. An experiment was conducted in a randomized complete block design using a factorial treatment arrangement of three genotypes by four mesotrione doses. Herbicide injury was rated visually on a scale of 0 (no injury) to 100 (complete plant mortality). The UAS flights were flown at 9, 15, 21, 27, and 35 days after treatment. Results show the SVM algorithm to be the most consistently accurate, and high correlations (r = -0.83 to -0.94; p < 0.0001) were observed between the normalized difference vegetative index (NDVI) and ground-measured herbicide injury. Therefore we conclude that VIs collected with UAS coupled with machine learning image classification, has the potential to be an effective method of evaluating mesotrione injury in grain sorghum.
Aplikasi Polyhalite sebagai Pengganti ZK dan Pengaruhnya terhadap Kadar K, Mg, dan S Daun, Produksi, dan Mutu Buah Jeruk Siam
Authors: Sutopo Sutopo , Aji Titistyas Gusti
Published: October 2020

As a natural mineral that contains several macro elements, polyhalite (K2Ca2Mg (SO4) 4H2O) has good potential as a fertilizer. This study aims to study the effect of polyhalite on branch growth, leaf nutrition (K, Mg and S), chlorophyll index, harvest weight, fruit quality, and the effective dose of Siam citrus. A 4-year-old Siam citrus planted on vertisol soil was treated with 6 fertilizer treatments: 625; 1,000; 1,375; 1,750; 2.125 kg polyhalite and 625 kg ZK/hectare/year. The experiment using a randomized block design was repeated 3 times. The results showed that
the application of polyhalite at the same K2O dose as ZK increased leaf Mg content, chlorophyll index and total juicesolids significantly. Polyhalite application of 1,750 kg/hectare (2.8 kg/tree) is an effective dose for mature Siam citrus in vertisol with moderate K status and high Ca and Mg status.
The Effect of Transformational Leadership and Work Motivation on Innovative Behavior
Authors: Purnomo Hadi Tavip , Tola Burhanuddin , Akbar Ma'ruf
Published: October 2020

This research is entitled "The Effect of Transformational Leadership and Work Motivation towards the Innovative Behavior". This research aims to determine the direct and indirect effects of transformational leadership work motivation on innovative behavior. The research approach is a quantitative method with path analysis. The population of this research is the medical representative from 3 pharmaceutical companies, taken proportionally in the Greater Jakarta Area of each company, namely: PT. X 40 people, PT. Y 40 people and PT. Z 30 people, with an affordable population of 110 people. The sampling technique was Simple Random Sampling through Krejcie and Morgan Tables, so that a representative sample of 86 respondents was obtained. Data collection was carried out through a Likert model structured questionnaire of the independent and dependent variables. The next step is to test the validity with Pearson Product Moment test analysis and reliability test with Cronbach Alpha test. Then the data analysis is performed as a statistical test requirement, namely; error normality test with Liliefors, homogeneity test and significance and linearity regression coefficient test. Found several conclusions, as follows; first, there is a direct effect of Transformational Leadership on Work Motivation, which means that transformational leadership styles can increase work motivation; second, there is a direct effect of Transformational Leadership on Innovative Behavior, which means that transformational leadership styles can enhance innovative behavior; third, there is a direct influence of Work Motivation on Innovative Behavior, which means work motivation can enhance innovative behavior; fourth, there is an indirect effect of Transformational Leadership on Innovative Behavior through Work Motivation, which means that transformational leadership styles can indirectly enhance innovative behavior through work motivation
Analysis Of Factors That Effect Lecturer Productivity Producing International Scientific Article In Private University: Motivation As A Moderating Variable
Authors: Andriani Dewi , Purwana Dedi , Susita Dewi
Published: October 2020

In accordance with the demands facing global challenges, lecturers are one of the important factors for creating competent university graduates, and the main role of colleges/universities is teaching, research and community service and directed to expand knowledge and open new avenues of science and technology. The purpose of this study is to analyze the factors that affect the productivity of lecturers producing international scientific article in Private Universities by using the Structural Equation Modeling. The data used are primary data by conducting surveys with a total of 310 respondents, and the analysis used includes validity, reliability, multiple linear regression, sobel tests, and hypothesis testing. The results showed that the positive direct effect of  Reward System, Transformational Leadership Style, Communication and Motivation on Lecturer Productivity. Furthermore. From the four exogenous variables, Communication proved to be the most dominant influence on Productivity, amounting to 5,132, and also the results of the study showed that the positive indirect effect through Motivation was a moderating variable.
The Effect of Occupational Safety, Work Skills, And Employability on Stress and Implications on The Productivity of Employment Construction Service Workers
Authors: Nurhani  , Wibowo  , Santoso Budi
Published: October 2020

This study aims to analyze the effect of occupational safety, work skills, and employability on stress and its implications on the labor productivity of construction service workers in Jabodetabek. This researcher uses a quantitative approach with a survey method. The sample used in this study are 303 permanent workforce in the construction service sector of  structure work ( formwork, putting ironn and casting ) who have a minimum of high school education equivalent that determines proportionate random sampling. The research data were obtained from distributing questionnaires and analyzed using Structural Equation Modeling (SEM) analysis supported by descriptive statistical analysis. The results of this study indicate occupational safety, work skills, employability and stress have a direct effect on work productivity; occupational safety, work skills and employability have a direct effect on stress; occupational safety, work skills and employability have a indirect effect on work productivity with stress mediation. Therefore, improvements in occupational safety, work skills, employability, and stress can increase work productivity. The novelty of this study is in the form of a research model of the effect of occupational safety, work skills, and employability on work productivity with stress mediation developed from previous relevant studies with construction service research locations in Jabodetabek, 2019.
The Influence Of Organizational Culture, The Attitude Of The Lecturer Toward Women’s Leadership, And Job Satisfaction On Organizational Commitment In The ‘Aisyiyah University Yogyakarta
Authors: Setyawati Rufaida , Akbar Ma'ruf , Luddin Muchlis R.
Published: October 2020

The research is conduted to find the relationship between organizational culture, ob statistifaction, and the attitude of lecturers who were not serving in leadership, both structural and functional positions toward women’s leadership on organizational commitment in ‘Aisyiyah University (UNISA) Yogyakarta. The population of the research was 153 people, then the number of samples was determined by following the Slovin formula and obtained 111 respondents. Samples used as respondents from each faculty and study program were determined randomly. so the sampling technique is included in the category of random sampling. The research method uses a quantitative approach with survey data collection methods, and uses path analysis techniques. The findings of this research are 1) there is a positive direct effect of organizational culture on organizational commitment, 2) there is a direct negative effect on organizational culture on job satisfaction, 3) there is a positive direct effect of attitudes on women's leadership on job satisfaction, 4) there is a positive direct effect of organizational culture on organizational commitment, 5) there is a positive direct effect of attitudes on women's leadership on organizational commitment, 6) there is a direct positive direct effect on job satisfaction on organizational commitment, 7) there is an indirect direct negative effect on women's organizational culture on organizational commitment through job satisfaction, 8) there is a direct indirect effect of positive attitudes towards women's leadership on organizational commitment through job satisfaction.
Adapting and Extending a Typology to Identify Vaccine Misinformation on Twitter
Authors: Jamison Amelia , Broniatowski David A. , Smith Michael C. , Parikh Kajal S. , Malik Adeena , Dredze Mark , Quinn Sandra C.
Published: October 2020

Objectives. To adapt and extend an existing typology of vaccine misinformation to classify the major topics of discussion across the total vaccine discourse on Twitter.

Methods. Using 1.8 million vaccine-relevant tweets compiled from 2014 to 2017, we adapted an existing typology to Twitter data, first in a manual content analysis and then using latent Dirichlet allocation (LDA) topic modeling to extract 100 topics from the data set.

Results. Manual annotation identified 22% of the data set as antivaccine, of which safety concerns and conspiracies were the most common themes. Seventeen percent of content was identified as provaccine, with roughly equal proportions of vaccine promotion, criticizing antivaccine beliefs, and vaccine safety and effectiveness. Of the 100 LDA topics, 48 contained provaccine sentiment and 28 contained antivaccine sentiment, with 9 containing both.

Conclusions. Our updated typology successfully combines manual annotation with machine-learning methods to estimate the distribution of vaccine arguments, with greater detail on the most distinctive topics of discussion. With this information, communication efforts can be developed to better promote vaccines and avoid amplifying antivaccine rhetoric on Twitter.
Leverage dan growth opportunity mempengaruhi nilai perusahaan melalui profitabilitas
Authors: Setiyowati Supami Wahyu , Naser Jamal Abdul , Astuti Rini
Published: October 2020

Companys value is a reflectiond or good name of company. The company value means a lot to investors and potential investors. This researcsh aims to examined the effect of leverage and growth opportunityd on corporate value through profitability. In this studys, the populations of consumer goods companies listesd on the Indonesia Stock Exchange in the 2015-2017 period is used. This study used 15 companies as samples. Data processing techniques using path analysis. The results of the leverage study have a negative effect on profitability. A high amount of debt reduces profits. Growth opportunity affects profitability. Increase in assets increases profits. leverge has a negative effect on firm value. A high amount of debt reduces the value of the company. Growth opportunity has a positive effect on firm value. An increase in assets or sales increases the value of the company. Profitability has an effect on firm value. Profits increase firm value. The effect of leverage on firm value with profitability as an intervening variable is not proven. Profitability indirectly has no effect on the relationship between leverage and firm value. The effect of growth opportunity on firm value with profitability as an intervening is proven. Indirectly, profitability affects the relationshipd of growth opportunitsy and firm value. Companies must have right strategy in terms of using funds from outside the company to increase company value.
Перенос свободного метана струйными газовыделениями из анаэробных в аэробные воды Чёрного моря
Authors: Артёмов Ю. Г.
Published: October 2020

«Дыхание недр» в форме метановых струйных газовыделений из морского дна (метановые сипы, или пузырьковые эманации) — явление планетарного масштаба, на которое обратили внимание лишь в конце XX столетия. Изучение этого явления как важного звена процессов взаимодействия литосферы, гидросферы, атмосферы и биосферы не потеряло своей актуальности до настоящего времени. В данной работе определены потоки метана в известном районе интенсивных метанопроявлений биогенной природы, географически привязанных к палеоруслу р. Днепр в северо-западной части Чёрного моря. Впервые оценено, что поток струйного (свободного) метана из анаэробных в аэробные воды на участке активных метановых газовыделений в районе палеорусла р. Днепр в диапазоне глубин 140–725 м составляет (в среднем по участку) 1,2·10³ м³·км−2·год−1 (STP), или 2,8 % от выделившегося из дна струйного метана. Величина исследованного потока — 4,2 % от удельного потока струйного метана в водный столб на шельфовом участке (глуби́ны менее 140 м) в этом же районе. Полученная в работе оценка потока метана — значимый экологический фактор в условиях стратификации вод Чёрного моря, где перенос метана струйными газовыделениями является основным механизмом внесения глубоководного метана в биогеохимические циклы и процессы трансформации углерода аэробной зоны Чёрного моря.