bluuebunny/crossref_metadata_2025 huggingface dataset:
Referring expressions in categorizing activities
Authors: Mayes Patricia , Tao Hongyin
Published: November 2019

Linguistic units as traditionally conceived by linguists favor structural features and referential meanings. In this paper, we propose a new way of understanding the nature of linguistic units by analyzing the interaction of multiple semiotic resources (gestures, bodily movement, eye gazeandspeech) in social interaction. We focus on the discursive activity of “categorizing” in different situations and in two languages, English and Mandarin Chinese. Categorizing is broadly defined as any activity that involves explicitly or implicitly classifying people or objects into types. We show that the meanings of linguistic units (including the referential) may be distorted or incomplete when forms are extracted from their contexts and analyzed in isolation. Instead, we argue that an interactional, activity-based view, focusing on the deployment of linguistic elements as part of a coordinated system of semiotic resources, will enable us to understand the nature of linguistic units in a more productive way.
Truth, person, and personal truth
Authors: Donohue Mark , Gautam Bhojraj
Published: November 2019

In this paper we present data on the copula system of Kuke, a language of the lower Nubri valley, in northern Nepal. We present data showing that the system of copulas cannot easily be categorised in terms of the different descriptive categories that are frequently used in discussion of languages of the Himalayan region (evidentiality, egophoricity, conjunct/disjunct). Further, the different contrasts encoded in the morphologically simple copula system shows a range of semantics (loosely associated with first person interpretations) that has rarely been described as occurring in one system.
The predicate as a locus of grammar and interaction in colloquial Indonesian
Authors: Ewing Michael C.
Published: November 2019

Descriptions of Indonesian usually take the clause as the starting point for analysing grammatical structure and rely on the notion of ellipsis to account for the way speakers actually use language in everyday conversational interaction. This study challenges the status of “clause” by investigating the structures actually used by Indonesian speakers in informal conversation and it demonstrates that the predicate, rather than the clause, plays a central role in the grammar of Indonesian conversation. The preponderance of predicates in the data that do not have explicit arguments suggests that this format is best viewed as the default. When a predicate is produced without overt arguments, reconstructing what arguments may have been elided is often ambiguous or indeterminate and seems to be irrelevant to speakers. An examination of turn-taking, overlap and incrementing in conversation also shows that predicates, rather than full clauses, are the grammatical format participants regularly orient to.
Subtle priming of subtraction versus addition: a spill-over effect of math / La inducción sutil de sumar vs. restar: un efecto indirecto de las matemáticas
Authors: Paredes Borja , Guyer Joshua J. , Briñol Pablo , Petty Richard E.
Published: November 2019

Studies on bias correction have often used blatant inductions to motivate people to reduce the mental impact of perceived biases. In the current research, we test a relatively unexplored, subtle way of inducing bias correction based on the activation of different calculative mindsets. Across two studies, participants were exposed to an advertisement introducing a new consumer product delivered by a credible or non-credible source. Then, as part of an ostensibly unrelated study, participants completed mathematical operations that involved subtracting or adding. Study 1 revealed that when participants were primed with an addition calculative mindset, an expert source elicited more favourable attitudes towards the product than a non-expert source. This pattern illustrates the traditional effect of source credibility on persuasion. In contrast, within the subtraction calculative mindset condition, persuasion was no different between an expert and a non-expert source. These results were obtained exclusively under high thinking conditions (e.g., for participants high in Need for Cognition). This finding can be interpreted as if the effect of source credibility was subtracted from the evaluative judgement. Study 2 replicated this two-way interaction using different materials and inductions. The present research has implications for bias correction, procedural priming, persuasion and beyond.
Psychological and Endocannabinoid Responses to Aerobic Exercise in Substance use Disorder Patients
Authors: Brellenthin Angelique G. , Crombie Kevin M. , Hillard Cecilia J. , Brown Randall T. , Koltyn Kelli F.
Published: November 2019

Background

Exercise has been examined as an adjunctive treatment for substance use disorders (SUDs), yet few exercise interventions have been conducted among patients undergoing intensive outpatient (IOP) treatment, who may be the most vulnerable to relapse and for whom exercise could provide the most benefits. This study examined the effects of aerobic exercise, in addition to IOP treatment, on psychological variables and endocannabinoids in individuals with SUDs. Methods: Twenty-one SUD patients (mean age 35 years) were recruited from local IOPs. Participants were randomized to either treatment-as-usual (TAU, at their outpatient clinic) or TAU plus aerobic exercise training (EX). EX participants engaged in supervised, moderate-intensity exercise for 30 min, 3 times/week for 6 weeks. TAU participants came into the laboratory once per week for assessments and a 30-min quiet rest session. Participants provided blood samples and completed questionnaires evaluating substance use, mood states, depression, anxiety, perceived stress, self-efficacy to abstain from substance use, and craving. Data were analyzed with Mann–Whitney U tests or mixed model ANOVAs to determine group differences in outcomes acutely and over 6 weeks.

Results

Over 6 weeks, there were reductions in perceived stress ( p < 0.01) and craving ( p < 0.05) for both groups. There were no group differences in abstinence rates or changes from baseline in self-efficacy, depression, or anxiety ( p > 0.05). Acutely, both exercise and quiet rest sessions led to reductions in craving, tension, depression, anger, confusion, and total mood disturbance (all ps < 0.05). In addition, the EX group experienced acute increases in vigor and circulating concentrations of the endocannabinoid, anandamide ( p < 0.01).

Conclusions

An adjunctive aerobic exercise program during SUD treatment was associated with similar reductions in perceived stress and drug craving as standard care. Thirty minutes of exercise or quiet rest led to acute improvements in mood, but exercise produced the additional benefit of increases in vigor and circulating anandamide.
Concerns regarding immigration in Germany: how subjective fears, becoming unemployed and social mobility change anti-immigrant attitudes
Authors: Stawarz Nico , Müller Michael
Published: November 2019

This article analyzes how anti-immigrant attitudes shift when individuals experience changes in their subjective and objective economic situations. To do this, we use data from the German Socio-Economic Panel Study (GSOEP, N ≈ 14,700) and apply fixed-effects multinomial logit panel regression models as a statistical framework. The social identity approach is applied as a theoretical perspective to explain how individual incidents can lead to group-based devaluations. Our findings show almost no effect of social mobility and shifts in the household income, while more disruptive events, such as becoming unemployed, significantly increase the probability of having stronger anti-immigrant attitudes. However, the largest shift in anti-immigrant attitudes is observed when fears of a worsening economic situation increase.
Magnetoresistance from time-reversal symmetry breaking in topological materials
Authors: de Boer Jorrit C , Leusink Denise P , Brinkman Alexander
Published: November 2019

Magnetotransport measurements are a popular way of characterizing the electronic structure of topological materials and often the resulting datasets cannot be described by the well-known Drude model due to large, non-parabolic contributions. In this work, we focus on the effects of magnetic fields on topological materials through a Zeeman term included in the model Hamiltonian. To this end, we re-evaluate the simplifications made in the derivations of the Drude model and pinpoint the scattering time and Fermi velocity as Zeeman-term dependent factors in the conductivity tensor. The driving mechanisms here are the aligment of spins along the magnetic field direction, which allows for backscattering, and a significant change to the Fermi velocity by the opening of a hybridization gap. After considering 2D and 3D Dirac states, as well as 2D Rashba surface states and the quasi-2D bulk states of 3D topological insulators, we find that the 2D Dirac states on the surfaces of 3D topological insulators produce magnetoresistance, that is significant enough to be noticable in experiments. As this magnetoresistance effect is strongly dependent on the spin-orbit energy, it can be used as a telltale sign of a Fermi energy located close to the Dirac point.
The Rise of Behavioral Economic Masculinity
Authors: Chihara Michelle
Published: November 2019

This essay begins a cultural history of the behavioral economic narrative mode in American popular media, in relation to the academic discipline but not coincident with it. From podcasts to Michael Lewis’s books and films, the behavioral economic mode of narration changes the character or figure of economic knowledge. Instead of the distant financial expert, this mode insists on the authority of the friendly explainer. In the years around the 2008 crisis, at a moment when financial scandals seemed to be losing their power to scandalize, this mode asserted behavioral economic knowledge as the new standard of realism. As the affective structures beneath earlier capitalist realist narratives diminished in power, the behavioral economic turn marked a reassertion of narrative authority. The behavioral mode instantiated a new relationship to a familiar misogyny and is perhaps best understood as a cultural shift with varied ideological commitments to economic philosophy itself. The behavioral economic mode is characterized by scenes of objectivity training or moments where the viewer or reader is trained to understand objectivity as a performance of distance from the subject’s gender or race. Not incidentally, this performance is demanded specifically of those who do not fit the neoclassical ideal of the rational agent and who are not white and not male.
Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia: A Longitudinal Study of Implant and Other Related Risk Factors
Authors: Loch-Wilkinson Anna , Beath Kenneth J , Magnusson Mark R , Cooter Rodney , Shaw Karen , French James , Vickery Karen , Prince H Miles , Deva Anand K
Published: November 2019

Background

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging cancer that has been linked to the use of textured devices. The recent increase in number and frequency of cases has led to worldwide regulatory action.

Objectives

The authors aimed to longitudinally study BIA-ALCL in Australia since the index case was first reported in 2007.

Methods

Confirmed historical cases were collected and then prospectively analyzed from October 2015 to May 2019. Clinical and implant exposure data were determined and compared with company sales data for 4 devices to generate implant-specific risk.

Results

A total 104 cases of BIA-ALCL were diagnosed in Australia with exposure to 149 unique breast implants. The mean age of patients was 48.2 years (range, 22.4-78.5 years). They had an average time from implantation to diagnosis of 6.8 years. A total 51.7% of implants utilized in this cohort were Allergan Biocell devices. The indication for implant usage was for primary cosmetic augmentation in 70%, post-breast cancer reconstruction in 23%, and following weight loss/pregnancy in 7%. The majority of women presented with early (stage 1) disease (87.5%). The risk for developing BIA-ALCL ranged from 1 in 1947 sales (95% confidence interval = 1199-3406) for Silimed Polyurethane devices to 1 in 36,730 (95% confidence interval = 12,568-178,107) for Siltex imprinted textured devices.

Conclusions

Implants with higher surface area/texture seem to be more associated with BIA-ALCL in Australia. Recent regulatory action to suspend, cancel, or recall some of these higher risk devices is supported by these findings.

Level of Evidence: 2
A comprehensive comparison and overview of R packages for calculating sample entropy
Authors: Chen Chang , Sun Shixue , Cao Zhixin , Shi Yan , Sun Baoqing , Zhang Xiaohua Douglas
Published: November 2019

Sample entropy is a powerful tool for analyzing the complexity and irregularity of physiology signals which may be associated with human health. Nevertheless, the sophistication of its calculation hinders its universal application. As of today, the R language provides multiple open-source packages for calculating sample entropy. All of which, however, are designed for different scenarios. Therefore, when searching for a proper package, the investigators would be confused on the parameter setting and selection of algorithms. To ease their selection, we have explored the functions of five existing R packages for calculating sample entropy and have compared their computing capability in several dimensions. We used four published datasets on respiratory and heart rate to study their input parameters, types of entropy, and program running time. In summary, NonlinearTseries and CGManalyzer can provide the analysis of sample entropy with different embedding dimensions and similarity thresholds. CGManalyzer is a good choice for calculating multiscale sample entropy of physiological signal because it not only shows sample entropy of all scales simultaneously but also provides various visualization plots. MSMVSampEn is the only package that can calculate multivariate multiscale entropies. In terms of computing time, NonlinearTseries, CGManalyzer, and MSMVSampEn run significantly faster than the other two packages. Moreover, we identify the issues in MVMSampEn package. This article provides guidelines for researchers to find a suitable R package for their analysis and applications using sample entropy.
Highly Sensitive Determination of Bisphenol A in Bottled Water Samples by HPLC after Its Extraction by a Novel Th-MOF Pipette-Tip Micro-SPE
Authors: Kaykhaii Massoud , Yavari Eilnaz , Sargazi Ghasem , Ebrahimi Ahmad Khajeh
Published: November 2019

In this study, a novel thorium metal organic framework was synthesized, characterized and used as a sorbent for very efficient pipette tip micro solid-phase extraction of bisphenol A in bottled drinking water samples using high-performance liquid chromatography as detecting instrument. Parameters which influence extraction efficiency such as pH, sample volume, amount of sorbent, type and volume of eluent, number of aspirating and dispensing cycles for extraction and elution, and volume of the sample solution were studied and optimized. A linear calibration curve was obtained in the range of 0.002–0.456 ng mL−1 (r2 = 0.996) with a detection limit of 0.0010 ng mL−1. Repeatability of batch-to-batch extraction was better than 5.0% and a reproducibility of 3.2% for real samples obtained.
The role of home visits by a nurse to improve palliation in patients treated with self-expandable metallic stents due to incurable esophageal cancer
Authors: Bjerring O S , Larsen M K , Fristrup C W , Lundell L , Mortensen M B
Published: November 2019

Self-expandable metallic stent (SEMS) is a preferred option to relieve dysphagia and to palliate patients with incurable esophageal or gastro-esophageal junction (GEJ) cancer. Health Related Quality of Life (QoL) represents a clinically relevant outcome measure in research focused on palliation of patients with advanced GI cancer. In this context, home visits by a nurse carry the potential to offer important advantages. Eighty patients with incurable esophageal or GEJ cancer were randomized to either standard follow up or to an intervention containing regular home visits by a nurse. The primary outcome variable QoL was assessed by EORTC QLQ-C30 and OES-18 before insertion of SEMS, and at 2, 7 and 12 weeks thereafter. Secondary outcomes were; need for re-interventions, number of patients receiving palliative oncological therapy and overall survival. Sixty-six males and 13 females, with a median age of 71, were included. Self-reported overall QoL was significantly higher in the intervention group (P = 0.03). The organ specific module OES-18 revealed a significant reduction in dysphagia by the intervention (P = 0.03) as well as fewer eating disabilities (P = 0.04). No differences were observed in secondary outcomes except for overall survival, where the median survival was increased from 114 to 183 days by the active intervention (P = 0.02). Home visits by a nurse seem to play an important palliative role after placement of SEMS in patients with incurable esophageal or GEJ cancer by improving QoL and may carry the potential to increase overall survival.
Derivation and validation of a mortality risk prediction model using global longitudinal strain in patients with acute heart failure
Authors: Hwang In-Chang , Cho Goo-Yeong , Choi Hong-Mi , Yoon Yeonyee E , Park Jin Joo , Park Jun-Bean , Park Jae-Hyeong , Lee Seung-Pyo , Kim Hyung-Kwan , Kim Yong-Jin , Sohn Dae-Won
Published: November 2019

Aims

To develop a mortality risk prediction model in patients with acute heart failure (AHF), using left ventricular (LV) function parameters with clinical factors.

Methods and results

In total, 4312 patients admitted for AHF were retrospectively identified from three tertiary centres, and echocardiographic parameters including LV ejection fraction (LV-EF) and LV global longitudinal strain (LV-GLS) were measured in a core laboratory. The full set of risk factors was available in 3248 patients. Using Cox proportional hazards model, we developed a mortality risk prediction model in 1859 patients from two centres (derivation cohort) and validated the model in 1389 patients from one centre (validation cohort). During 32 (interquartile range 13–54) months of follow-up, 1285 patients (39.6%) died. Significant predictors for mortality were age, diabetes, diastolic blood pressure, body mass index, natriuretic peptide, glomerular filtration rate, failure to prescribe beta-blockers, failure to prescribe renin–angiotensin system blockers, and LV-GLS; however, LV-EF was not a significant predictor. Final model including these predictors to estimate individual probabilities of mortality had C-statistics of 0.75 [95% confidence interval (CI) 0.73–0.78; P < 0.001] in the derivation cohort and 0.78 (95% CI 0.75–0.80; P < 0.001) in the validation cohort. The prediction model had good performance in both heart failure (HF) with reduced EF, HF with mid-range EF, and HF with preserved EF.

Conclusion

We developed a mortality risk prediction model for patients with AHF incorporating LV-GLS as the LV function parameter, and other clinical factors. Our model provides an accurate prediction of mortality and may provide reliable risk stratification in AHF patients.
Minimally invasive surgical strategy for refractory hepatic hydrothorax
Authors: Jung Yochun , Song Sang Yun , Na Kook Joo , Chon Soon-Ho , Jun Chung Hwan , Choi Sung Kyu
Published: November 2019

OBJECTIVES

Treatment of refractory hepatic hydrothorax, a complication of liver cirrhosis, is complex. We aimed to investigate the usefulness of the ‘4-step approach’, which is a minimally invasive surgical strategy combining 4 therapeutic modalities: (i) pneumoperitoneum to localize diaphragmatic defects; (ii) thoracoscopic pleurodesis; (iii) postoperative positive-pressure ventilation; and (iv) peritoneal drainage for abdominal decompression.

METHODS

We retrospectively analysed the medical records of 12 patients with hepatic hydrothorax who underwent surgical treatment using the 4-step approach from January 2013 to December 2017. Nine of them (75.0%) were Child C cases; the median model for end-stage liver disease score was 20.5. The diaphragmatic defects localized after forming a pneumoperitoneum were treated with primary closure followed by thoracoscopic pleurodesis, postoperative positive-pressure ventilation and peritoneal drainage.

RESULTS

Diaphragmatic defects were localized in all patients except one. The median postoperative positive-pressure ventilation duration was 20.1 h. Peritoneal drainage was performed for a median duration of 5 days; the peritoneal drains were removed at a median of 8 postoperative days. The median duration of postoperative hospital stay until discharge/transfer was 9.5 days. No operative mortalities occurred. The median duration of follow-up was 10.9 months. Eight deaths (66.7%) occurred during the follow-up period; however, no deaths were surgery-associated. Ipsilateral pleural effusion recurred in 3 patients (25%), among whom reoperation was performed in 1 without recurrence at the 13-month follow-up.

CONCLUSIONS

The 4-step approach seems to be a safe and effective minimally invasive surgical strategy for treating refractory hepatic hydrothorax.
Deep learning for clustering of multivariate clinical patient trajectories with missing values
Authors: de Jong Johann , Emon Mohammad Asif , Wu Ping , Karki Reagon , Sood Meemansa , Godard Patrice , Ahmad Ashar , Vrooman Henri , Hofmann-Apitius Martin , Fröhlich Holger
Published: November 2019

Background

Precision medicine requires a stratification of patients by disease presentation that is sufficiently informative to allow for selecting treatments on a per-patient basis. For many diseases, such as neurological disorders, this stratification problem translates into a complex problem of clustering multivariate and relatively short time series because (i) these diseases are multifactorial and not well described by single clinical outcome variables and (ii) disease progression needs to be monitored over time. Additionally, clinical data often additionally are hindered by the presence of many missing values, further complicating any clustering attempts.

Findings

The problem of clustering multivariate short time series with many missing values is generally not well addressed in the literature. In this work, we propose a deep learning–based method to address this issue, variational deep embedding with recurrence (VaDER). VaDER relies on a Gaussian mixture variational autoencoder framework, which is further extended to (i) model multivariate time series and (ii) directly deal with missing values. We validated VaDER by accurately recovering clusters from simulated and benchmark data with known ground truth clustering, while varying the degree of missingness. We then used VaDER to successfully stratify patients with Alzheimer disease and patients with Parkinson disease into subgroups characterized by clinically divergent disease progression profiles. Additional analyses demonstrated that these clinical differences reflected known underlying aspects of Alzheimer disease and Parkinson disease.

Conclusions

We believe our results show that VaDER can be of great value for future efforts in patient stratification, and multivariate time-series clustering in general.
History of the Spanish demersal fishery in the Atlantic and Mediterranean Seas
Authors: Punzón Antonio , Rueda Lucia , Rodríguez-Basalo Augusto , Hidalgo Manuel , Oliver Pere , Castro José , Gil Juan , Esteban Antonio , Gil de Sola Luis , Massutí Enric
Published: November 2019

Long fisheries time series allow the review of baselines and inform our knowledge of past events that have conditioned the recent history of the stocks. In this study, we investigated trends in fisheries landings data for the most representative Atlantic and Mediterranean demersal fisheries off the Spanish Iberian Peninsula and the Balearic Islands (1933–1986). The aim was to analyse the evolution of demersal species exploitation and detect changes in landings and fishing tactics. Ten species were selected, which included teleosts, crustaceans, and cephalopods. Results indicated a decrease in Landings Per Unit of Capacity (LPUC) in six of the species examined. While in the Atlantic the process of substitution or incorporation of new species to the fisheries occurs progressively, in the Mediterranean this incorporation occurs simultaneously for many of the species. Four main fishing tactics (landing pattern obtained from the classification analysis of landings per species) were identified. Geographically nearby and connected regions developed similar fishing tactics to each other, and also changed over time. While the fleets from isolated regions were more specialized, and only carrying out one fishing tactic during the study period. Improvements in LPUC with the implementation of new technology and legislative and management measures were not observed.
Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression
Authors: Gryglewski Gregor , Seiger René , Baldinger-Melich Pia , Unterholzner Jakob , Spurny Benjamin , Vanicek Thomas , Hahn Andreas , Kasper Siegfried , Frey Richard , Lanzenberger Rupert
Published: November 2019

Background

Treatment-resistant depression is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with magnetic resonance imaging with poor antidepressant response. Therefore, the extent to which electroconvulsive therapy, the most effective therapeutic option for treatment-resistant depression, affects white matter microstructure warrants investigation.

Methods

A total 13 patients suffering from severe unipolar treatment-resistant depression underwent magnetic resonance imaging with a diffusion tensor imaging sequence before and after undergoing a series of right unilateral electroconvulsive therapy. Diffusivity metrics were compared voxel-wise using tract-based spatial statistics and repeated-measures ANOVA.

Results

A total 12 patients responded to electroconvulsive therapy and 9 were classified as remitters. An increase in axial diffusivity was observed in the posterior limb of the internal capsule of the right hemisphere (PFWE ≤ .05). The increase in this area was higher in the right compared with the left hemisphere (P < .05). No correlation of this effect with treatment response could be found.

Conclusions

The strong lateralization of effects to the hemisphere of electrical stimulation suggests an effect of electroconvulsive therapy on diffusivity metrics which is dependent of electrode placement. Investigation in controlled studies is necessary to reveal to what extent the effects of electroconvulsive therapy on white matter microstructure are related to clinical outcomes and electrode placement.
Sparsified discrete wave problem involving a radiation condition on a prolate spheroidal surface
Authors: Barucq Hélène , Fares M’Barek , Kruse Carola , Tordeux Sébastien
Published: November 2019

We develop and analyse a high-order outgoing radiation boundary condition for solving three-dimensional scattering problems by elongated obstacles. This Dirichlet-to-Neumann condition is constructed using the classical method of separation of variables that allows one to define the scattered field in a truncated domain. It reads as an infinite series that is truncated for numerical purposes. The radiation condition is implemented in a finite element framework represented by a large dense matrix. Fortunately, the dense matrix can be decomposed into a full block matrix that involves the degrees of freedom on the exterior boundary and a sparse finite element matrix. The inversion of the full block is avoided by using a Sherman–Morrison algorithm that reduces the memory usage drastically. Despite being of high order, this method has only a low memory cost.
The Large Genus Asymptotic Expansion of Masur–Veech Volumes
Authors: Sauvaget Adrien
Published: November 2019

We study the asymptotic behavior of Masur–Veech volumes as the genus goes to infinity. We show the existence of a complete asymptotic expansion of these volumes that depends only on the genus and the number of singularities. The computation of the 1st term of this asymptotics expansion was a long-standing problem. This problem was recently solved in [2] using purely combinatorial arguments and then in [3] using algebro-geometric insights. Our proof relies on a combination of both methods.
Journeying Through the Black Hole of Recycling
Authors: Hamilton Johanna
Published: November 2019

UK universities have a rich history of leading groundbreaking projects, spanning Nobel Prize winning discoveries, medicines and inventions. Standing on the shoulders of giants, Dr Alvin Orbaek White, Senior Lecturer and Sêr Cymru II Fellow at the Energy Safety Research Institute at Swansea University, tells Johanna Hamilton AMBCS how his findings could plug a recycling black hole.
Event Two: The BCS Computer Arts Society
Authors: Hamilton Johanna
Published: November 2019

In 1969, the newly formed Computer Arts Society staged its first show: the aptly named EVENT ONE. However, it was another fifty years before the advent of EVENT TWO. Johanna Hamilton AMBCS asks Graham Diprose Joint Chair of EVA London, about the inspirational five day show and its legacy.
Clinical Features and Expression Patterns for Burn Patients Developed Marjolin Ulcer
Authors: Li Dongyu , Hu Chenghao , Yang Xing , Dongye Yuhui , Wu Jiani , Zhang Haibo , Lin Yuxi , Li Huibin
Published: November 2019

Marjolin’s ulcer is a type of skin cancer that generated from chronic nonhealing trauma. For years, its pathogenesis mechanisms remain unclear. Regarding this situation, the authors retrospectively analyze the patients admitted to their department from 2005 to 2019 to present several representative cases and examine the expression patterns of survivin and its role in this process. Among these patients, the latent period ranges from 2 to 25 years, with 8.43 years in average. There is no notable relationship between the latent period and age (P = .643 > .05). Therefore, Marjolijn’s ulcer arises from extremities and joints more often compared with other parts (P < .05). The expression ratio of survivin in Marjolin’s ulcer is significantly higher than that in skin ulcer (P < 0.05). And the expression ratio of survivin in patients diagnosed with Marjolin’s ulcer is also correlated with lymphatic metastasis (P < .05). Frequent follow-ups and prompt diagnosis and management are necessary as the prognosis is poor for patients with metastasis. Survivin may be a potential target for future development of target therapy in order to maximize the efficacy and improve the quality of life for patients suffering from Marjolin’s ulcer.
Urbanization and Population Genetic Structure of the Panama City crayfish (Procambarus econfinae)
Authors: Duncan Sarah I , Robertson Ellen P , Fletcher Robert J , Austin James D
Published: November 2019

For species with geographically restricted distributions, the impacts of habitat loss and fragmentation on long-term persistence may be particularly pronounced. We examined the genetic structure of Panama City crayfish (PCC), Procambarus econfinae, whose historical distribution is limited to an area approximately 145 km2, largely within the limits of Panama City and eastern Bay County, FL. Currently, PCC occupy approximately 28% of its historical range, with suitable habitat composed of fragmented patches in the highly urbanized western portion of the range and managed plantations in the more contiguous eastern portion of the range. We used 1640 anonymous single-nucleotide polymorphisms to evaluate the effects of anthropogenic habitat modification on the genetic diversity and population structure of 161 PCC sampled from across its known distribution. First, we examined urban habitat patches in the west compared with less-developed habitat patches in the east. Second, we used approximate Bayesian computation to model inferences on the demographic history of eastern and western populations. We found anthropogenic habitat modifications explain the genetic structure of PCC range-wide. Clustering analyses revealed significant genetic structure between and within eastern and western regions. Estimates of divergence between east and west were consistent with urban growth in the mid-20th century. PCC have low genetic diversity and high levels of inbreeding and relatedness, indicating populations are small and isolated. Our results suggest that PCC have been strongly affected by habitat loss and fragmentation and management strategies, including legal protection, translocations, or reintroductions, may be necessary to ensure long-term persistence.
The country of Iceland freezes out the eponymous supermarket: ICELAND trade marks invalidated
Authors: Meale Darren , Walles Nicola
Published: November 2019

The Icelandic Ministry for Foreign Affairs and Others v Iceland Foods Limited, EUIPO Cancellation No 14 030 C (Invalidity), 5 April 2019; Icelandic Trade mark Holding ehf v Iceland Foods Limited, EUIPO Cancellation No. 19 387 C (Invalidity), 27 May 2019

Iceland Foods’ European Union trade marks for ICELAND were held invalid for all goods and services in a duo of recent decisions from the European Union Intellectual Property Office Cancellation Division, after The Icelandic Ministry for Foreign Affairs successfully argued that the exclusive rights conferred on the food and beverage retail giant unfairly monopolized what is, of course, the name of a country in the European Economic Area.
Free to Choose: A Moral Defense of the Right-to-Try Movement
Authors: Brodrick Michael
Published: November 2019

The claim that individuals legitimately differ with respect to their values seems to be uncontroversial among bioethicists, yet many bioethicists nevertheless oppose right-to-try laws. This seems to be due in part to a failure to recognize that such laws are intended primarily to be political, not legal, instruments. The right-to-try movement seeks to build political support for increasing access to newly developed drugs outside of clinical trials. Opponents of right-to-try laws claim that increasing access outside of clinical trials would undermine evidence-based medicine. They seek to maximize overall gains to patients by protecting them from adverse drug reactions and ensuring that drugs are more effective on average. In contrast, right-to-try activists have a point that regulatory judgments of drug safety and effectiveness impose one set of trade-offs on all individuals, regardless of their different values. That might be acceptable if determinations of safety and effectiveness were black and white, but that does not seem to be the case. This article argues that judgments of safety and effectiveness are in an important respect normative and reflect the perceived value of those ends relative to others. Such judgments, when universally imposed, harm patients who would readily make do with less knowledge of drug safety and effectiveness in exchange for more time and self-determination. The relevant moral principle is that of respect for individual autonomy. Just as that principle should lead one to substitute collective decisions for individual ones to regulate a natural monopoly, the same principle should lead one to substitute individual decisions for collective ones to avoid a government monopoly on access to newly developed drugs. It is argued that reforms should increase the number of treatment options available to patients outside of clinical trials. The final section of the article discusses ways in which current regulations might be reformed so as to provide more treatment options outside of clinical trials, without undermining evidence-based medicine.
Randomized Phase II Trial of Exercise, Metformin, or Both on Metabolic Biomarkers in Colorectal and Breast Cancer Survivors
Authors: Meyerhardt Jeffrey A , Irwin Melinda L , Jones Lee W , Zhang Sui , Campbell Nancy , Brown Justin C , Pollak Michael , Sorrentino Alexandra , Cartmel Brenda , Harrigan Maura , Tolaney Sara M , Winer Eric , Ng Kimmie , Abrams Thomas , Fuchs Charles S , Sanft Tara , Douglas Pamela S , Hu Frank , Ligibel Jennifer A
Published: November 2019

Background

Observational data support inverse relationships between exercise or metformin use and disease outcomes in colorectal and breast cancer survivors, although the mechanisms underlying these associations are not well understood.

Methods

In a phase II trial, stage I–III colorectal and breast cancer survivors who completed standard therapy were randomly assigned to structured exercise or metformin or both or neither for 12 weeks. The primary outcome was change in fasting insulin levels; secondary outcomes included changes in other blood-based energetic biomarkers and anthropometric measurements. Analyses used linear mixed models.

Results

In total, 139 patients were randomly assigned; 91 (65%) completed follow-up assessments. Fasting insulin levels statistically significantly decreased in all three intervention arms (−2.47 μU/mL combination arm, −0.08 μU/mL exercise only, −1.16 μU/mL metformin only, + 2.79 μU/mL control arm). Compared with the control arm, all groups experienced statistically significant weight loss between baseline and 12 weeks (−1.8% combination arm, −0.22% exercise only, −1.0% metformin only, +1.55% control). The combination arm also experienced statistically significant improvements in the homeostatic model assessment for insulin resistance (−30.6% combination arm, +61.2% control) and leptin (−42.2% combination arm, −0.8% control), compared with the control arm. The interventions did not change insulin-like growth factor–1 or insulin-like growth factor binding protein–3 measurements as compared with the control arm. Tolerance to metformin limited compliance (approximately 50% of the participants took at least 75% of the planned dosages in both treatment arms).

Conclusions

The combination of exercise and metformin statistically significantly improved insulin and associated metabolic markers, as compared to the control arm, with potential greater effect than either exercise or metformin alone though power limited formal synergy testing. Larger efforts are warranted to determine if such a combined modality intervention can improve outcomes in colorectal and breast cancer survivors.
Targeted misexpression of NAC052, acting in H3K4 demethylation, alters leaf morphological and anatomical traits in Arabidopsis thaliana
Authors: van Rooijen Roxanne , Schulze Stefanie , Petzsch Patrick , Westhoff Peter
Published: November 2019

In an effort to identify genetic regulators for the cell ontogeny around the veins in Arabidopsis thaliana leaves, an activation-tagged mutant line with altered leaf morphology and altered bundle sheath anatomy was characterized. This mutant had a small rosette area with wrinkled leaves and chlorotic leaf edges, as well as enhanced chloroplast numbers in the (pre-)bundle sheath tissue. It had a bundle-specific promoter from the gene GLYCINE DECARBOXYLASE SUBUNIT-T from the C4 species Flaveria trinervia (GLDTFt promoter) inserted in the coding region of the transcriptional repressor NAC052, functioning in H3K4 demethylation, in front of an alternative start codon in-frame with the natural start codon. Reconstruction of the mutation event of our activation-tagged line by creating a line expressing an N-terminally truncated sequence of NAC052 under control of the GLDTFt promoter confirmed the involvement of NAC052 in leaf development. Our study not only reveals leaf anatomic and transcriptomic effects of an N-terminally truncated NAC052 under control of the GLDTFt promoter, but also identifies NAC052 as a novel genetic regulator of leaf development.
The quenching and morphological evolution of central galaxies is facilitated by the feedback-driven expulsion of circumgalactic gas
Authors: Davies Jonathan J , Crain Robert A , Oppenheimer Benjamin D , Schaye Joop
Published: November 2019

We examine the connection between the properties of the circumgalactic medium (CGM) and the quenching and morphological evolution of central galaxies in the EAGLE and IllustrisTNG simulations. The simulations yield very different median CGM mass fractions, fCGM, as a function of halo mass, M200, with low-mass haloes being significantly more gas-rich in IllustrisTNG than in EAGLE. Nonetheless, in both cases scatter in fCGM at fixed M200 is strongly correlated with the specific star formation rate and the kinematic morphology of central galaxies. The correlations are strongest for ∼L⋆ galaxies, corresponding to the mass scale at which AGN feedback becomes efficient. This feedback elevates the CGM cooling time, preventing gas from accreting on to the galaxy to fuel star formation, and thus establishing a preference for quenched, spheroidal galaxies to be hosted by haloes with low fCGM for their mass. In both simulations, fCGM correlates negatively with the host halo’s intrinsic concentration, and hence with its binding energy and formation redshift, primarily because early halo formation fosters the rapid early growth of the central black hole (BH). This leads to a lower fCGM at fixed M200 in EAGLE because the BH reaches high accretion rates sooner, whilst in IllustrisTNG it occurs because the central BH reaches the mass threshold at which AGN feedback is assumed to switch from thermal to kinetic injection earlier. Despite these differences, there is consensus from these state-of-the-art simulations that the expulsion of efficiently cooling gas from the CGM is a crucial step in the quenching and morphological evolution of central galaxies.
Extracting the Global Signal from 21-cm Fluctuations: the Multi-Tracer Approach
Authors: Fialkov Anastasia , Barkana Rennan , Jarvis Matt
Published: November 2019

The multi-tracer technique employs a ratio of densities of two differently biased galaxy samples that trace the same underlying matter density field, and was proposed to alleviate the cosmic variance problem. Here we propose a novel application of this approach, applying it to two different tracers one of which is the 21-cm signal of neutral hydrogen from the epochs of reionization and comic dawn. The second tracer is assumed to be a sample of high-redshift galaxies, but the approach can be generalized and applied to other high-redshift tracers. We show that the anisotropy of the ratio of the two density fields can be used to measure the sky-averaged 21-cm signal, probe the spectral energy distribution of radiative sources that drive this signal, and extract large-scale properties of the second tracer, e.g., the galaxy bias. Using simulated 21-cm maps and mock galaxy samples, we find that the method works well for an idealized galaxy survey. However, in the case of a more realistic galaxy survey which only probes highly biased luminous galaxies, the inevitable Poisson noise makes the reconstruction far more challenging. This difficulty can be mitigated with the greater sensitivity of future telescopes along with larger survey volumes.
Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models
Authors: Downs Thomas R , Arlt Volker M , Barnett Brenda C , Posgai Ryan , Pfuhler Stefan
Published: November 2019

In vitro genotoxicity assays utilising human skin models are becoming important tools for the safety assessment of chemicals whose primary exposure is via the dermal route. In order to explore metabolic competency and inducibility of CYP450 activating enzymes, 3D reconstructed human skin tissues were topically treated with 2-acetylaminofluorene (2-AAF) and its genotoxic metabolites, N-hydroxy-2-acetylaminofluorene (N-OH-2-AAF) and N-hydroxy-2-aminofluorene (N-OH-2-AF), which primarily cause DNA damage by forming DNA adducts. 2-AAF did not increase DNA damage measured in the reconstructed skin micronucleus (RSMN) assay when administered in multiple applications at 24 h intervals but was detected in the skin comet assay in the presence of the DNA polymerase inhibitor aphidicolin (APC). Similarly, no increase was found with N-OH-2-AAF in the RSMN assay after multiple treatments whereas a single 3 h exposure to N-OH-2-AAF caused a large dose-related increase in the skin comet assay. A significant increase in the RSMN assay was only obtained with the highly reactive N-OH-2-AF metabolite after multiple treatments over 72 h, whereas N-OH-2-AF caused a strong increase after a single 3 h exposure in the skin comet assay. In support of these results, DNA adduct formation, measured by the 32P-postlabelling assay, was examined. Adduct levels after 2-AAF treatment for 3 h were minimal but increased >10-fold after multiple exposures over 48 h, suggesting that enzyme(s) that metabolise 2-AAF are induced in the skin models. As expected, a single 3 h exposure to N-OH-2-AAF and N-OH-2-AF resulted in adduct levels that were at least 10-fold greater than those after multiple exposures to 2-AAF despite ~100-fold lower tested concentrations. Our results demonstrate that DNA damage caused by 2-AAF metabolites is more efficiently detected in the skin comet assay than the RSMN assay and after multiple exposures and enzyme induction, 2-AAF-induced DNA damage can be detected in the APC-modified comet assay.
Requirements for DNA bubble structure for efficient cleavage by helix–two-turn–helix DNA glycosylases
Authors: Makasheva Kristina A , Endutkin Anton V , Zharkov Dmitry O
Published: November 2019

Oxidative DNA lesions, constantly generated by both endogenous and environmentally induced reactive oxygen species, are removed via the base excision repair pathway. In bacteria, Fpg and Nei DNA glycosylases, belonging to the helix–two-turn–helix (H2TH) structural superfamily, remove oxidised purines and pyrimidines, respectively. Interestingly, the human H2TH family glycosylases, NEIL1, NEIL2 and NEIL3, have been reported to prefer oxidative lesions in DNA bubbles or single-stranded DNA. It had been hypothesised that NEIL2 might be involved in the repair of lesions in transcription bubbles; however, bubble-like structures may appear in other cellular contexts such as displacement loops (D-loops) associated with transcription, recombination or telomere maintenance. The activities of bacterial Fpg and Nei on bubble substrates were not addressed. Also, it is not known whether H2TH enzymes process bubbles containing the third DNA or RNA strand, and how the bubble length and position of the lesion within a bubble affect the excision. We have investigated the removal of 8-oxoguanine (8-oxoG) and 5,6-dihydrouracil (DHU) by Escherichia coli Fpg and Nei and human NEIL1 and NEIL2 from single-strand oligonucleotides, perfect duplexes, bubbles with different numbers of unpaired bases (6–30), bubbles containing the lesion in different positions and D-loops with the third strand made of DNA or RNA. Fpg, NEIL1 and NEIL2 efficiently excised lesions located within bubbles, with NEIL1 and NEIL2 being specific for DHU, and Fpg removing both 8-oxoG and DHU. Nei, in contrast, was significantly active only on DHU located in double-stranded DNA. Fpg and NEIL1 also tolerated the presence of the third strand of either DNA or RNA in D-loops if the lesion was in the single-stranded part, and Fpg, Nei and NEIL1 excised lesions from the double-stranded DNA part of D-loops. The presence of an additional unpaired 5′-tail of DNA or RNA did not affect the activity. No significant position preference for lesions in a 12-mer bubble was found. Overall, the activities of Fpg, NEIL1 and NEIL2 on these non-canonical substrates are consistent with the possibility that these enzymes may participate in the repair in structures arising during transcription or homologous recombination.