bluuebunny/crossref_metadata_2025 huggingface dataset:
Isoquercetin Neuroprotective Molecular Targets in Parkinson’s Disease: Recent Highlights and Future Perspectives
Authors: Kaur Dilpreet , Singh Shamsher
Published: June 2024

Parkinson's disease (PD) is an age-related progressive neurodegenerative condition characterized
by dopaminergic neuronal loss in the brain's substantia nigra pars compacta (SNpc). Growing
evidence suggests that apoptosis, neuroinflammation, mitochondrial dysfunction, and oxidative
stress are important factors in the pathogenesis of Parkinson's disease. Isoquercetin is a natural flavanol
compound possessing anti-apoptotic, anti-inflammatory, anti-oxidant, and neuroprotective
activities. Isoquercetin also has the capability to modulate various signaling pathways such as Rho
signaling cascade, Nrf-2, TLR4, NF-κB, MAPK, Bcl-2, Bax proteins, which are well-known causes
for the progression of the disease. These pathways are involved in cellular homeostasis, transcription
of proinflammatory cytokines, oxidative stress, microglial activation, and regulation of the apoptotic
pathways. In this review, we have highlighted the mechanisms of the above-mentioned pathways and
their modulation via the flavonoid compound isoquercetin in various ways.
Urinary Exosomes (UE): Unique Clinical Signature of Liquid Biopsy in
Cancer
Authors: Ashique Sumel
Published: June 2024

Liquid biopsy is indeed a non-invasive diagnostic method that has gained significant
attention in the field of medicine and healthcare. It involves detecting and analyzing
biomarkers in bodily fluids, such as blood, urine, or cerebrospinal fluid, to provide
valuable information for diagnosing, prognosis, and monitoring various diseases, particularly
cancer. Addressing the need for innovative approaches in the diagnosis and treatment of
cancer, researchers are focused on identifying new biomarkers for diagnosis, prognosis,
treatment selection, and therapy monitoring.
Efficiency of Glucosamine in Treating Temporomandibular Joint Osteoarthritis: A Systematic Review
Authors: Sivakumar Sasidharan , Kumar P. Prem , Prasanna P. Lakshmi , Sivakumar Gowardhan , Balasamy Sesuraj , Sundramoorthy Ashok K.
Published: June 2024

Background:

Temporomandibular joint osteoarthritis (TMJ OA) is a chronic disease
that is a consequence of undue occlusal forces and is characterized by irreversible damage to the
articular surfaces. Symptomatic slow-acting so-called nutraceutical drugs have been proposed as a
treatment for osteoarthritis in comparison to non-steroidal anti-inflammatory drugs (NSAIDs).
Oral glucosamine and chondroitin, slow-acting drugs, have been found to reduce pain and increase
mouth opening in patients with TMJ OA. However, there is limited scientific evidence to
confirm their clinical effectiveness.

Aim:

This systematic review was conducted to bolster the evidence supporting the assessment of
the efficacy of glucosamine in the context of temporomandibular joint osteoarthritis (TMJ OA).

Methodology:

This review identified four review articles from databases like Medline (via
PubMed), Web of Science, Scopus, and EMBASE till September 2023 after screening at the title,
abstract, and full-text level. They were assessed for risk of bias with the JBI risk of bias assessment
tool.

Result:

This review with meta-analysis focused on pooled estimate mean differences, revealing
non-significant but discernible effects of glucosamine on maximum mouth opening (SMD =
0.288, p = 0.15) and pain reduction (SMD = 0.217, p = 0.476) in TMJ-related disorders.

Conclusion:

Compared to control groups with ibuprofen and tramadol, glucosamine showed
slightly more favourable outcomes. However, the variability in methodology and study characteristics
warrants further longitudinal studies to confirm its efficacy.
Assessing the Impact of Essential and Leisure Internet Use and Related Happiness on Internet Addiction in Early and Middle Adolescents: A Cross-Sectional Study (Preprint)
Authors: Chemnad Khansa , Aziz Maryam , Al- Harahsheh Sanaa , Abdelmoneium Azza , Baghdady Ahmed , Alsayed Hassan Diana , Ali Raian
Published: June 2024

BACKGROUND

Adolescent Internet addiction (IA) has become a growing concern in today's society as the use of technology and the Internet has become increasingly prevalent in the lives of young people.

OBJECTIVE

Our study aims to differentiate between screen time spent on essential activities and non-essential Internet activities and how they relate to internet addiction (IA) in early and middle adolescents. Conducted among adolescents of Arab origin, our study addresses the limitation of the literature, which predominantly focuses on WEIRD (Western, educated, industrialized, rich, and democratic) populations.

METHODS

This study surveyed 377 adolescents in Qatar. The survey gathered information on participants' demographics, the Internet Addiction Diagnostic Questionnaire, time spent on essential and non-essential Internet use, and subjective happiness associated with the amount of time spent on non-essential Internet use. Factorial analysis, multiple regression, and logistic regression were used for statistical analysis.

RESULTS

Results: Time spent on non-essential Internet use predicted IA in early and middle adolescents, whereas essential Internet use did not. Happiness with time spent on non-essential Internet use negatively predicted IA in middle adolescents only; greater dissatisfaction led to a higher IA risk.

CONCLUSIONS

Conclusion: Findings suggest that interventions aimed at addressing IA should focus on addressing non-essential use specifically rather than considering Internet use and screen time in general as a single entity. This approach can help effectively address factors contributing to IA.
Що таке хвороба X?
Authors: Duda O.K. , Batsyura G.V. , Boyko V.O. , Pechinka A.M. , Golub A.P. , Kotsyubailo L.P.
Published: June 2024

Хвороба X — це умовна назва патології, яка була прийнята Всесвітньою організацією охорони здоров’я у лютому 2018 року, у списку пріоритетних хвороб, що можуть становити найбільший ризик для здоров’я населення, як гіпотетичний невідомий збудник, що спричинить майбутню пандемію. ВООЗ прийняла це рішення, щоб гарантувати, що планування буде достатньо гнучким для адаптації до невідомого патогену. Так, у 2020 р. експерти припустили, що COVID-19, викликаний штамом вірусу SARS-CoV-2, відповідає цим вимогам і є першою хворобою X.
Diagnostic performance of sex hormone binding globulin (SHBG) expression in predicting prostate cancer (PCa)
Authors: Lubis Anggiat Pratama , Danarto H R , Indrawarman
Published: June 2024

Globally, 1.3 million new cases of prostate cancer (PCa) and 359,000 deaths were reported in 2018. Due to rapid population growth and increasing rates of aging worldwide, the PCa has become the 5th leading cause of death in men. Sex hormone binding globulin (SHBG) presents in both men and women and its expression is often associated with the development of PCa and breast cancers. This study was conducted to assess the diagnostic performance of SHBG expression in predicting PCa. A total of 31 patients with PCa and 14 patients with BPH as a control were involved in this study. The SHBG expression of formalin-fixed paraffin-embedded (FFPE) prostate tissue was examined by the quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Receiver operator characteristic (ROC) curves were produced and the area under the curve (AUC) was calculated to evaluate the diagnostic performance of the SHBG expression in predicting the PCa. The AUC of SHBG expression was 0.868 (95% CI 0.764-0.971; p<0.001) which indicated good diagnostic performance. The cutoff value was 6.731 which corresponded to 80% accuracy, 71% sensitivity, and 100% specificity. In conclusion, SHBG expression in bladder cancer tissues could be a molecular marker in PCa diagnosis.
 
ABSTRACT
 
Secara global terdapat 1,3 juta kasus baru kanker prostat (prostate cancer/PCa) dan 359.000 kematian dilaporkan pada tahun 2018. Karena pertumbuhan populasi yang cepat dan meningkatnya angka usia lanjut di seluruh dunia, PCa telah menjadi penyebab kematian utama ke-5 pada pria. Sex hormone binding globulin (SHBG) terdapat pada pria dan wanita dan ekspresinya sering dikaitkan dengan perkembangan PCa dan kanker payudara. Penelitian ini dilakukan untuk menilai potensi SHBG sebagai penanda molekuler dalam diagnosis PCa. Sebanyak 31 pasien PCa dan 14 pasien BPH sebagai kontrol dilibatkan dalam penelitian ini. Ekspresi SHBG dari jaringan prostat formalin-fixed paraffin-embedded (FFPE) diperiksa dengan the quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Receiver operator characteristic (ROC) dihasilkan dan the area under the curve (AUC) dihitung untuk mengevaluasi kinerja diskriminatif ekspresi SHBG dalam diagnosis PCa. AUC ekspresi SHBG adalah 0,868 (95% CI 0,764-0,971; p<0,001) yang menunjukkan kinerja diskriminatif yang baik. Nilai cutoff adalah 6,731 yang berhubungan dengan akurasi 80%, sensitivitas 71% dan spesifisitas 100%. Kesimpulannya, ekspresi SHBG pada jaringan kanker kandung kemih dapat menjadi penanda molekuler dalam diagnosis PCa
Toxoplasmosis in cats from a dairy-producing region in Hidalgo, Mexico
Authors: Ramirez-Perez Lizbeth , Rico Torres Claudia Patricia , Valenzuela Moreno Luis Fernando , Cedillo-Pelaez Carlos , Caballero-Ortega Heriberto , Acosta-Salinas Rosalinda , Villalobos Nelly , Martínez Maya José Juan
Published: June 2024

Considering that the ingestion of cat feces containing Toxoplasma gondii oocysts is a major transmission route for toxoplasmosis, this work is aimed to assess the presence of T. gondii in cats dwelling in dairy production facilities at the Tizayuca Agro-Industrial Complex (CAIT, by its acronym in Spanish) in Hidalgo, Mexico. Blood samples from stray and owned cats were assayed by indirect ELISA, and samples from various tissues were collected at post-mortem examination of positive cats for DNA extraction, PCR, histopathologic studies, and immunohistochemistry. A questionnaire was applied in each dairy production unit to estimate cat ownership. From 70 animals studied (22 stray and 48 owned), 12 (17.1 %) were seropositive (7 stray and 5 owned). No differences were found for age or sex according to the questionnaires, but ingesting raw food was a risk factor (P < 0.01). Of the 12 positive cats, 5 were euthanized; of these, five tissue samples from 4 cats were positive for the B1 and 529 bp repetitive sequences by qPCR and conventional PCR. No macro- or microscopic lesions suggestive of T. gondii infection were found in cats.
On Groups in the Qubit Clifford Hierarchy
Authors: Anderson Jonas T.
Published: June 2024

Here we study the unitary groups that can be constructed using elements from the qubit Clifford Hierarchy. We first provide a necessary and sufficient canonical form that semi-Clifford and generalized semi-Clifford elements must satisfy to be in the Clifford Hierarchy. Then we classify the groups that can be formed from such elements. Up to Clifford conjugation, we classify all such groups that can be constructed using generalized semi-Clifford elements in the Clifford Hierarchy. We discuss a possible minor exception to this classification in the appendix. This may not be a full classification of all groups in the qubit Clifford Hierarchy as it is not currently known if all elements in the Clifford Hierarchy must be generalized semi-Clifford. In addition to the diagonal gate groups found by Cui et al., we show that many non-isomorphic (to the diagonal gate groups) generalized symmetric groups are also contained in the Clifford Hierarchy. Finally, as an application of this classification, we examine restrictions on transversal gates given by the structure of the groups enumerated herein which may be of independent interest.
Using Advanced Machine Learning Techniques to Predict the Sales Volume of Non-Fungible Tokens
Authors: Çamalan Özge , Gökmen Şahika , Atan Sibel
Published: June 2024

Non-fungible tokens (NFTs) are a type of digital asset based on blockchain that contain unique codes verifying the authenticity and ownership of different assets such as art pieces, music, gaming items, collections, and so on. This phenomenon and its markets have grown significantly since the beginning of 2021. This study, using daily data between November 2017 and November 2022, predicts the volume of NFT sales by utilising Random Forest (RF), GBM, XGBoost, and LightGBM methods from the community machine learning methods. In the predictions, several financial variables, including Gold, Bitcoin/USD, Ethereum/USD, S&P 500 index, Nasdaq 100, Oil/USD, Euro/USD, and CDS data, are treated as independent variables. According to the results, XGBoost is found to be the best prediction method for NFT market volume estimation concerning several statistical criteria, e.g., MAE, MAPE, and RMSE, and the most significant influential feature in determining prices is the Ethereum/USD exchange rate.
Real-World Evidence of Indapamide-Induced Rhabdomyolysis: A Retrospective Analysis of Electronic Health Records
Authors: Alroba Raseel , Alfakhri Almaha , Badreldin Hisham A. , Alrwisan Adel , Almadani Ohoud A.
Published: June 2024

Purpose: This study aims to investigate the potential causal
relationship between the use of indapamide and rhabdomyolysis. Previous
research and pharmacovigilance monitoring activities have suggested a
potential association between indapamide use and rhabdomyolysis.
However, limited information is available on this association.
Methods: A case-control study conducted using EHR data, between
July 1,2016, and December 31,2022. Patients who have rhabdomyolysis
event (cases) were matched to four controls bases on age, gender and
date. We examined the odds for indapamide exposure through three risk
periods: current use, recent use, and former. The study outcome was
ascertained through the presence of CK level over 1,000 U/L (i.e.
rhabdomyolysis event). Subsequently, a multivariable conditional
logistic regression analysis was utilized to assess the causal impact of
indapamide exposure on the likelihood of developing rhabdomyolysis,
while accounting for potential confounding variables. Results:
The study population consisted of 2,965 cases and 11,860 controls. The
results of the conditional logistic regression analysis indicated a lack
of association between exposure to indapamide for the current users the
OR was 0.7 (95% CI: 0.49 - 0.92) and the AOR was 0.6 (95% CI: 0.39 -
1.05). The recent users showed OR of 0.9 (95% CI: 0.56 - 1.50) and AOR
of 0.2 (95% CI: 0.14 - 0.47). Lastly, the former users demonstrated an
OR of 0.8 (95% CI: 0.47 - 1.26), and AOR of 0.1 (95% CI: 0.07 - 0.23).
Conclusions: In this study, we did not find association between
indapamide use and rhabdomyolysis regardless timing of exposure.
Trends, Hotspots, and Future Directions of Inflammation in Age-Related Macular Degeneration: A 20-Year Bibliometric Analysis
Authors: Lu Fangfang , Wang Zhi , Lu Jing , Jiang Weijie , Zhang Jia , Fei Zhigang , Xiao Qiguo
Published: June 2024

Background Inflammation significantly impacts the pathogenesis of
age-related macular degeneration (AMD), the primary cause of vision loss
in the elderly. With the aging global population and increasing
incidence of AMD, understanding the inflammation-related mechanisms and
identifying potential therapeutic targets have become paramount. This
study aims to offer a bibliometric analysis of global research
contributions focused on inflammation in AMD, shedding light on research
trends, collaborations, and future directions. Methods We retrieved
publications related to inflammation in AMD from 2003 to 2023 from the
Web of Science Core Collection database. A total of 2044 articles were
analyzed using VOSviewer, CiteSpace, and R-bibliometrix to examine
publication trends, influential countries, institutions, authors, and
journals, as well as emerging research topics. Results Our analysis
revealed a steady global increase in annual publications. The United
States and China emerged as leading contributors, demonstrating
substantial collaboration and investment in AMD research. Among
institutions, the National Eye Institute in the United States and the
University of Eastern Finland stood out for their prolific
contributions. Key researchers such as K. Kaarniranta have been central
to advancing the field, offering potential collaboration opportunities.
Investigative Ophthalmology & Visual Science and Experimental Eye
Research were identified as the top journals publishing significant work
on inflammation in AMD. Keywords such as “oxidative stress,”
“complement” “autophagy,” “macrophage,” and “microglia” were
frequently mentioned, highlighting these as current research hotspots.
Conclusion This analysis underscores the importance of inflammation in
AMD and maps the evolution of research, suggesting future directions
that may offer new therapeutic strategies.
Identification of differentially methylated regions (DMRs) associated with leaf physiological acclimation to experimental long-term drought in holm oak ( Quercus ilex L.)
Authors: Jalon Laura Garcia de , Limousin Jean-Marc , Mirouze Marie , Picault Nathalie , Gessler Arthur , Milcu Alexandru
Published: June 2024

Shifts in rainfall patterns and increasing temperatures associated with
climate change are causing widespread forest decline, especially due to
the increase and duration of droughts. Tree species may have to quickly
adapt to these changing conditions, and epigenetic modifications are
expected to play a key role in regulating rapid acclimation responses.
In this study, we measured acclimation physiological responses and
methylome responses in mature holm oak trees ( Quercus ilex L.)
subjected to 15 years of experimental accrued drought (-29% of
rainfall) and their respective controls with ambient rainfall. We
hypothesized that: i) oak trees exposed to long-term drought will
exhibit different foliar traits due to adaptative phenotypic plasticity
to drought, ii) methylation levels will differ between the drought and
control trees allowing the identification of drought-induced
differentially methylated regions (DMRs), and iii) these DMRs correlate
with the differences in foliar traits. Our results confirmed all
hypotheses. The methylome analysis revealed 84 drought-related DMRs
among trees from different precipitation treatments, of which 17 DMRs
were significantly associated with measured phenotypic responses. This
study provides evidence of the role of epigenetic regulation for tree
acclimation responses in natural populations of holm oak facing
increased droughts and identified candidate genes potentially involved
in drought adaptation.
Diversity and potential host-interactions of gut viruses in the black-necked crane (Grus nigricollis)
Authors: Li Wenhao , Yu Mengshi , Lin Qianqi , Xiong yi , Yao Yongfang , Xu Huailiang , He Guiwen , Zhao Junsong
Published: June 2024

Less is known about the interaction of viruses with their prokaryotic
host in the gut of wild animal. Here we used fecal DNA metagenomic data
(n = 24) from black-necked cranes during the wintering period for virus
characterization. The results were found to be consistent with the trend
of bacterial community changes, and the black-necked crane gut viruses
community structure was conservative during the wintering period. A
total of 280 vOTUs (6 complete, 3 HQ, 2 MQ and 269 LQ) were obtained and
life history predictions identified 207 virulent viruses. 269 LQ vOTUs
contained at least 10 viral genes, hence several of these viruses may be
too distinct from viral species in the CheckV database to properly
estimate their completeness. Meanwhile, gene-sharing network analysis
revealed that the gut viruses of black-necked crane formed 32 unique
viral clusters (VCs). Virus taxonomic assignment has revealed that
Azeredovirinae is the most abundant family during the wintering period
of black-necked cranes. Furthermore. Black-necked crane gut viruses have
a complex relationship with their prokaryotic hosts, and virus-encoded
auxiliary metabolic genes (AMGs) enhance the potential of infecting
bacteria for chitin degradation, methionine and tetrahydrofolate (THF)
metabolism. These results imply the presence of a large number of novel
viruses in the intestinal tract of black-necked cranes, which may
further affect birds by regulating prokaryotic bacterial metabolism
including lyse prokaryotic host cells and encodes AMGs related to the
degradation of complex carbohydrates and amino acid metabolism.
A Link Between U.S. East Coast Sea Level and North Atlantic Subtropical Ocean Heat Content
Authors: Steinberg Jacob M. , Griffies Stephen M , Krasting John P , Piecuch Christopher G. , Ross Andrew
Published: June 2024

Using a recently developed 1/12th degree regional ocean model, we
establish a link between U.S. East Coast sea level variability and
offshore upper-ocean heat content change. This link manifests as a
cross-shore mass redistribution driven by an offshore thermosteric sea
level response to subsurface warming or cooling. Approximately
50\% of simulated monthly to inter-annual coastal sea
level variance south of Cape Hatteras can be statistically accounted for
by this mechanism, realized as a function of regional ocean hypsometry,
gyre scale warming, and the depth-dependence of density change. This
response to offshore warming explains the non-stationarity of U.S. East
coast sea level covariance, specifically observed and modeled behavior
after $\sim$ 2010. Since approximately 2010, elevated
rates of sea level rise south of Cape Hatteras can be partly explained
as the result of shore-ward mass redistribution due to offshore
sub-surface warming within the North Atlantic subtropical gyre. These
results reveal a mechanism that connects local coastal sea level to a
broader region and identifies the influence of regional heat content
changes on coastal sea level. This analysis presents a framework for
identifying new regions that may be susceptible to enhanced sea level
rise due to ocean warming and helps bridge the gap between quantifying
large scale change and anticipating local coastal impacts like flooding
and storm surge.
Curriculum: Opiniones y búsqueda de rigor conceptual
Authors: Darós W. R.
Published: June 2024

Este estudio trata de mostrar la importancia y la influencia de la epistemología en el currículo para educar a un hombre crítico. Los buenos medios son fundamentales a la hora de alcanzar la meta. Se estamos a apontar um pensamento crítico e pluralista numa sociedade democrática como uma boa meta na educação, então a epistemologia pode ser um excelente meio que deve estar presente no quadro do currículo. Les écoles ne sont pas, bien sûr, la seule cause et responsable des problèmes sociaux, mais elles doivent offrir des instruments efficaces pour comprendre et être actifs dans le monde des hommes. Y en este caso, un currículo basado en la epistemología -como forma crítica de pensar- es una buena opción.
Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling
Authors: Wolf Sonya J. , Audu Christopher O. , Moon Jadie Y. , Joshi Amrita D. , Melvin William J. , Barrett Emily C. , Mangum Kevin , de Jimenez Gabriela Saldana , Rocco Sabrina , Buckley Sam , Ahmed Zara , Wasikowski Rachael , Kahlenberg J. Michelle , Tsoi Lam C. , Gudjonsson Johann E. , Gallagher Katherine A.
Published: June 2024

Macrophage (Mφ) plasticity is critical for normal wound repair; however, in type 2 diabetic wounds, Mφs persist in a low-grade inflammatory state that prevents the resolution of wound inflammation. Increased NLRP3 inflammasome activity has been shown in diabetic wound Mφs; however, the molecular mechanisms regulating NLRP3 expression and activity are unclear. Here, we identified that diabetic wound keratinocytes induce Nlrp3 gene expression in wound Mφs through IL-1 receptor–mediated signaling, resulting in enhanced inflammasome activation in the presence of pathogen-associated molecular patterns and damage-associated molecular patterns. We found that IL-1α is increased in human and murine wound diabetic keratinocytes compared with nondiabetic controls and directly induces Mφ Nlrp3 expression through IL-1 receptor signaling. Mechanistically, we report that the histone demethylase, JMJD3, is increased in wound Mφs late post-injury and is induced by IL-1α from diabetic wound keratinocytes, resulting in Nlrp3 transcriptional activation through an H3K27me3-mediated mechanism. Using genetically engineered mice deficient in JMJD3 in myeloid cells (Jmjd3f/flyz2Cre+), we demonstrate that JMJD3 controls Mφ-mediated Nlrp3 expression during diabetic wound healing. Thus, our data suggest a role for keratinocyte-mediated IL-1α/IL-1R signaling in driving enhanced NLRP3 inflammasome activity in wound Mφs. These data also highlight the importance of cell cross-talk in wound tissues and identify JMJD3 and the IL-1R signaling cascade as important upstream therapeutic targets for Mφ NLRP3 inflammasome hyperactivity in nonhealing diabetic wounds.

Article Highlights
Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia
Authors: Bonifazi Alessandro , Ellenberger Michael , Farino Zachary J. , Aslanoglou Despoina , Rais Rana , Pereira Sandra , Mantilla-Rivas José O. , Boateng Comfort A. , Eshleman Amy J. , Janowsky Aaron , Hahn Margaret K. , Schwartz Gary J. , Slusher Barbara S. , Newman Amy Hauck , Freyberg Zachary
Published: June 2024

Dopamine (DA) D2-like receptors in both the central nervous system (CNS) and the periphery are key modulators of metabolism. Moreover, disruption of D2-like receptor signaling is implicated in dysglycemia. Yet, the respective metabolic contributions of CNS versus peripheral D2-like receptors, including D2 (D2R) and D3 (D3R) receptors, remain poorly understood. To address this, we developed new pharmacological tools, D2-like receptor agonists with diminished and delayed blood-brain barrier capability, to selectively manipulate D2R/D3R signaling in the periphery. We designated bromocriptine methiodide (BrMeI), a quaternary methiodide analog of D2R/D3R agonist and diabetes drug bromocriptine, as our lead compound based on preservation of D2R/D3R binding and functional efficacy. We then used BrMeI and unmodified bromocriptine to dissect relative contributions of CNS versus peripheral D2R/D3R signaling in treating dysglycemia. Systemic administration of bromocriptine, with unrestricted access to CNS and peripheral targets, significantly improved both insulin sensitivity and glucose tolerance in obese, dysglycemic mice in vivo. In contrast, metabolic improvements were attenuated when access to bromocriptine was restricted either to the CNS through intracerebroventricular administration or delayed access to the CNS via BrMeI. Our findings demonstrate that the coordinated actions of both CNS and peripheral D2-like receptors are required for correcting dysglycemia. Ultimately, the development of a first-generation of drugs designed to selectively target the periphery provides a blueprint for dissecting mechanisms of central versus peripheral DA signaling and paves the way for novel strategies to treat dysglycemia.

Article Highlights
To the issue of the right of employees to disconnect: a comparative analysis
Authors: Vakariuk L. V. , Getmantseva N. D.
Published: June 2024

The article states that the widespread use of the Internet and computer technology requires an adequate legislative response to challenges. The development of legislation should take into account the changes taking place in the country’s economy. Unfortunately, we have to state the fact that the national legislation still does not always respond to new threats in a timely and qualitative manner. It is emphasized that the problems caused by the impact of digital technologies on work emphasize that in the digital age occupational health and safety remains the main asset designed to protect the health of workers. The right to disconnection plays a key role in maintaining the balance between work and personal life, preserving the health of the employee.
It is emphasized that taking into account the experience of enshrining the right to disconnection in the labor legislation of the leading EU countries will be relevant and useful for our country, in which digitization has been accelerating at an accelerated pace in recent years. The national legislation of Ukraine still does not always respond in a timely and qualitative manner to new challenges and needs related to the digitalization of the labor sphere. Attention is drawn to the fact that the Ukrainian legislator not only unreasonably limited the categories of employees who have the right to disconnect to only those who perform work remotely, but also adopted declarative norms without defining a clear mechanism for implementing the right to disconnect in practice.
It is noted that filling this legislative gap is possible with the help of local regulation. Local regulations that detail the legal regulation of this issue at the level of enterprises, institutions, and organizations play an important role in protecting the employee from excessive workloads caused by performing work with the help of ICT. Enshrining at the legislative level clear mechanisms for the implementation of the right to disconnection, further detailing it in local acts, and its effective use in practice are necessary steps to improve the life and health of employees.
Procedural form as a category of administrative law and procedure
Authors: Puzyrnyi O. O.
Published: June 2024

This scientific article explores the issue of procedural form as a crucial category in the context of administrative law and contemporary judicial proceedings. The essence and role of the procedural form in resolving administrative disputes and establishing the rights and obligations of process participants are examined.
The article highlights the historical development of the concept of «procedural form» in administrative law and analyzes current trends in its definition and application. Special attention is given to the impact of this category on ensuring justice and the efficiency of administrative justice.
The research also focuses on practical aspects of applying the procedural form in the field of administrative law, considering the importance of ensuring access to justice and timely case resolution. Specific recommendations are proposed for improving legislation and practices in administrative proceedings, taking into account the studied aspects of procedural form.
The obtained results can be valuable for scholars, practitioners, and legislators interested in issues of administrative law and procedure. Additionally, the article explores the correlation between procedural form and key principles of administrative justice, such as the principles of legality, rights and freedoms of citizens, transparency, and openness of judicial proceedings.
In the context of current socio–cultural and technological changes, it is necessary to analyze the impact of innovative approaches to judicial proceedings on procedural form and the efficiency of administrative justice. The article considers not only theoretical aspects but also practical issues related to the development and improvement of procedural legislation in administrative law.
Possible obstacles and challenges in implementing modern approaches to procedural form are discussed, along with suggested strategies to overcome them. This article serves as a significant contribution to the development of scientific discourse on administrative justice and procedure, presenting new ideas and concepts that can be used for further research in this field.
The role and significance of the phenomenon of the first love of youth in the formation of legal (legally significant) behavior about
Authors: Zinsu O. I.
Published: June 2024

The article presents the results of a theoretical and empirical study of the phenomenon of “first love” of youth. The relevance of the research topic is dictated by the social and practical significance of the influence of the first love of youth on the regulation of the legal behavior of an individual. The work highlights the approbation and results of the developed author’s questionnaire “Outlook features of behavior and feelings of first love in the period of youth”. According to the author’s developed questionnaire, the results of the analysis of respondents from Kyiv, Zhytomyr, and Dnipropetrovsk regions of Ukraine are presented.
The connection of the imprinted model of behavior in first love with the subsequent style of family and marital relations is asserted. It is emphasized that the mental reality of the first love in youth is settled by a deep experience between sexual relations, ethical and aesthetic criteria, which significantly affects the choice of a marriage partner, and therefore the formation of legal (legally significant) behavior in the family, family, everyday life. Mechanisms of psychological protection that pose a risk to the physical, mental, and psychological well-being of an individual are identified. Pay attention to the peculiarities of the victim behavior of youth. It was concluded that the experience of an unrequited, treacherous, abandoned first love leaves wounds in the depths of the psyche and provokes the development of low self-esteem, feelings of inferiority, which are reflected in unbearable suffering and pain in subsequent romantic relationships between the sexes. In connection with this, the role of ethical, moral, and legal education of youth, aimed at analyzing the holistic perception of the reality of first love and preventing possible deformations and crises, increases.
The obtained results of the research can be used in: - scientific research field - for further scientific research of legal behavior; - educational activities - for the preparation and conducting of lectures, seminars and practical classes and during the writing of textbooks, training manuals on the educational disciplines “Legal Psychology”; “Personality psychology”, “Preventive psychology”, “Family law”, “Prevention and countermeasures against domestic violence”. The provisions of this study can also be used during the development of targeted legal education programs and trainings.
Problems of the imperfection of the conceptual apparatus, the system of covert investigative (search) actions, the determination of their procedural forms
Authors: Babikov O.
Published: June 2024

The article is devoted to the study of the problems of imperfection of the conceptual apparatus of the system of covert investigative (detective) actions, the definition of their procedural forms. The unsuccessful approach of the legislator to the definition of the system of covert investigative (search) actions in the Criminal Procedure Code of Ukraine, which provides for their delineation into those related to interference in private communication and others, the ambiguity of wording and the absence of clear criteria for such concepts as: “fact” conducting covert investigative (search) actions”, “method of covert investigative (search) actions”; “exceptionality” – the impossibility of obtaining information in another way; “another person” who can be involved in secret investigative (search) actions; “circumstances that give reason to suspect a person of committing a criminal offense” as a legal and factual basis for restricting human rights and freedoms when conducting secret investigative (search) actions; “results of secret investigative (search) actions” in the context of the notification of the person in respect of whom it was conducted; the meaning of the concept of “private” and “private communication” and many others. It is pointed out that the imperfection of the conceptual apparatus makes it difficult to understand certain measures of tacitly obtaining and recording information as one or more procedural actions that are related to each other, but differ in content, procedure and features of recording. In particular, the author proposed ways to solve this problem by making changes to the Criminal Procedure Code of Ukraine, as well as by specifying their content in the Instructions on the organization of secret investigative (search) actions and the use of their results in criminal proceedings, to determine and specify the limits of permissible interference in private a life that a modern democratic legal state can afford.
Evaluation of CDL- CQI monitoring mechanism in open distance learning (ODL) of materials science and technology course during COVID-19 pandemic
Authors: Ratim Suzana , Zakaria Rosnah , Gisip Judith , Ibrahim Norazura , Jani Nur Aimi
Published: June 2024

The COVID-19 pandemic has necessitated a rapid shift to online and distance learning modalities that may impact the quality assurance of teaching and learning process, particularly in higher education. This study focuses on the evaluation of a Closing the Loop - Continuous Quality Improvement (CDL-CQI) through monitoring mechanism implemented in an Open Distance Learning (ODL) of Materials Science and Technology programme. The primary objective is to evaluate the educational quality among the ODL students while being at home during COVID-19 pandemic. A comprehensive assessment of the CDL-CQI monitoring mechanism was conducted by employing a mixed-methods approach. Quantitative and qualitative data were gathered through various parameters such as examination grade, surveys and feedback , outcomes-based education-student centred learning (OBE-SCL), course-program-learning outcomes and soft skills. The CDL-CQI results indicated a statistically significant improvement of GPA grade in learning outcomes with the implementation of these monitoring tools. Learners reported increased engagement , enhanced self-directed learning skills, and improved interaction with course materials in ODL. The findings suggested that CDL-CQI tools have a positive effect on the quality of education in ODL environments. The implications of this study extend to both educational practitioners and policymakers involved in curriculum reviews. The results underscore the potential of CDL-CQI tools to foster a more dynamic and responsive learning environment, ultimately leading to enhanced learning outcomes attainment. By integrating these monitoring tools strategically, educators can better tailor their instruction and support to individual student’s needs.
Simulation Marks (SimMarks) app: an approach to fix the coursework assessment gap problem among lecturers
Authors: Muhammad Fathullah Muhammad Farid , Ismail Siti Isma Hani , Zakariah Zulfairul , Mohd Latib Farah Wahida , Nazarudin Ainamardia , Bachok Mohd Fairuz
Published: June 2024

Nowadays in China, the English proficiency of non-English majors in universities and colleges, in general, is not as satisfactory as expected. One of the reasons is supposed to be the sharp decrease of English input during classroom time, compared with that in junior and senior high school. The research investigates whether monolingual teaching is a possible answer to the problem and the role of the monolingual classroom in improving students’ listening performance. The research is quantitative innature. It adopts a quasi-experimental design, with two classes of freshmen as participants, one being the experimental group, receiving monolingual teaching while the other is the control group, which receives traditional bilingual teaching. In each class, there are 40 students. Before and after the implementation of 15 weeks’ monolingual teaching, all the students have to take the pretest and posttest respectively. Besides, all the students have to take The Self-assessment Scales in China’s Standards of English Language Ability before and after the implementation of monolingual teaching to see whether they themselves consider their listening ability as having improved. Together with the interview on some students, the research finds that students’ listening performance in the experimental group does have a statistically significant improvement, compared with the control group and that L2 can help to change the class atmosphere and inspire students to learn English. The research serves as an empirical evidence for the effectiveness of monolingual teaching on students’ listening ability, as well as an indication for the direction in how to help the reform of foreign language teaching, especially English teaching in universities and colleges in China in the future.
Why new media communication? Exploring the motivation of female students in a new media communication programme
Authors: Ibnu Ireena Nasiha , Sapari Fatin Najihah , Alimom Norasikin
Published: June 2024

Motivation has been underscored as an important component of student learning in the educational sector. New Media Communication is important more today than ever due to the fast growing globalisation of all facets of life.. The current study explores female students’ motivation in the New Media Communication programme. It is to be noted that , female students are lesser than male students every year, according to student admission statistics at Universiti Teknologi Mara (UiTM). Since this programme is still considered new in UiTM, (which first started in 2017), the public domain have yet to learn of its contents and what this course could offer in the future. The foundation of the New Media Communication programme is the exploration of interactive, gamified, and animated media in the production of digital content. This study aims to attract female students to apply to the New Media Communication programme when they pursue their studies so that it has equality between the numbers of female and male students. The methodology used will be a qualitative research method. Several female students from the New Media Communication programme were interviewed to for the study. Findings from this study show that their motivations are a dynamic blend of personal passion, career aspirations, and the transformative potential of new media technologies. In conclusion, this study underscores the importance of fostering an environment that acknowledges these motivations and actively supports and promotes them, ultimately contributing to the advancement and innovation of the new media communication field.
Indies y profesionales: Sellos y amistades en La Plata
Authors: Boix Ornela
Published: June 2024

El indie en Argentina es una configuración socioestética que a comienzos de los 2000 vino a renovar la tradición del rock nacional. A partir de una etnografía de larga duración (2009-2016), a la que se agrega un trabajo de archivo posterior que repone los derroteros del indie a mayor escala, este libro tiene como objetivo principal presentar y analizar la configuración de la música indie en la ciudad de La Plata como una escena de escala media que cuenta con sus modelos específicos de institucionalización, apreciación, trabajo y profesionalización. Este fenómeno se analiza como una articulación singular de producir, escuchar, difundir, presentar e identificar la música. De esta manera, el trabajo pretende contribuir a los estudios sociales de la música en tres sentidos: ofrece una lectura etnográfica del indie, en cuanto dispositivo cultural en el cual intervienen distintos sujetos, estructuras y materialidades; propone una versión del método etnográfico atenta a la reflexividad y a la producción de la teoría como diálogo; y por último, elabora una mirada histórica del fenómeno, que interesa por su carácter emergente.
STUDY OF THE PARTICIPIAL FORMS OF THE ARMENIAN LANGUAGE IN THE SYSTEM OF THE THEORY OF THE VERB A. ABRAHAMYAN (According to the monograph "The Verb in Modern Armenian")
Authors: AVAGYAN ANI
Published: June 2024

The article briefly analyzes the participle  forms of Modern Armenian in the theory of A. A. Abrahamyan in his monograph "The Verb in Modern Armenian".   We show that Abrahamyan distinguishes the category of grammatical state, which differs, for example, from the Russian corresponding category (category of  state). 
Further, we give the following semantic grouping made by the venerable linguist: 1) brief, vague, weak manifestation, 2) expressive but not expressing a temporal state, 3) expressing a general temporal state, without omitting the attention of other researchers - M. Abeghyan, H. Acharyan, E. Aghayan, G. Jahukyan and G. Sevak.
  А. Abrahamyan singles out a new type of participle form (i.e. ընթացակցական դերբայ [ǝntcakccakan derbay] "accompanying participle form"), clarifies some other similar forms, especially on the basis of their function.
The theoretical analysis and distinctions are substantiated by the textual examples given, taken not only from Modern Literary Armenian, but also from its dialects.
It should also be noted that such classification, repeatedly take place in the researches of specialists of Modern Literary Armenian.
STYLISTIC IMPLICATIONS OF USING FOREIGN WORDS IN STORY “THE LOST DOVE” BY NAR-DOS
Authors: HOVHANNISYAN ZHENYA
Published: June 2024

This article presents a linguistic study of foreign words used in Nar-Dos’s story “The Killed Dove”, using relevant examples. Foreign words that were transferred from Russian and other languages to Armenian and the reasons for their use were mentioned. Foreign language quotes, words that have only a stylistic connotation, as well as words that do not have Armenian equivalents in the new period of the history of the Armenian language were presented. The study also talks about the significant similarity of foreign languages.
Considering the difference between foreign words and borrowings in the Armenian language to be a priority problem, we also noted the boundaries of words of this order, since at present, in the course of the development of the literary language, there is some confusion in resolving the issue of distinguishing between foreign and borrowed words.
   In the story, some truly Armenian and foreign words are used in parallel (խելացի – ինտելիգենտ,   սովորական - պրոզայիկ, etc.), due to the tendency of the stylistic coloring of the author's speech.
There are also many cases when the corresponding phraseological units are used to give the speech a satirical tone and make fun of one of the characters. similar shades of speech are clearly expressed in the story under discussion (prosecutor, amateur, intellectual, etc.).
We also highlighted frequently used foreign words in the mentioned story by Nar-Dos and thereby came to the conclusion that the author’s language is not free from unnecessary use of such words and word forms.