bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudo de caso de um serviço de reabilitação auditiva na Cidade de São Paulo
Authors: Ragusa-Mouradian Cláudia Aparecida , Momensohn-Santos Teresa Maria
Published: August 2021

Apresentar estudo de caso de um serviço de reabilitação auditiva do Município de São Paulo. Reorganização do processo de reabilitação auditiva do paciente, proposta pela Área Técnica da Pessoa com Deficiência da Secretaria Municipal de Saúde, introduzindo o Acolhimento Multiprofissional Compartilhado, com vistas ao estabelecido na Linha de Cuidados e do Projeto Terapêutico Singular. Anteriormente, os pacientes da região agendados para diagnóstico, cumpriam o seguinte Protocolo: 1. Médico otorrinolaringologista – Entrada no Serviço; 2. Avaliação Audiológica; 3. Otorrinolaringologista - diagnóstico e conduta; 4. Fonoaudiólogo – pré-molde e pré-seleção do aparelho; 5. Fonoaudiólogo – Teste e definição do Aparelho e 6. Entrega/Dispensação do Aparelho, sendo que tal processo da entrada à concessão dos dispositivos auditivos de amplificação levava até 12 meses. A reorganização aconteceu em 4 Fases: 1. (abril/2015) - agendamento para realização das Etapas 1, 2 e 3 do Protocolo; 2. (outubro/2015) - inclusão da Etapa 4 (1 otorrinolaringologista e 2 fonoaudiólogos); 3. (janeiro/2017) - inclusão segundo otorrinolaringologista e única forma de entrada no serviço; 4. (abril/2017) - inclusão do Serviço Social. Com esse modelo de funcionamento, foi constatada a redução no número de retornos, otimização das agendas, melhoria do acesso ao serviço e redução do tempo entre a primeira consulta e a concessão dos dispositivos auditivos de doze (12) para quatro (4) meses. O processo do paciente para a reabilitação auditiva dentro do Serviço foi todo reestruturado e descrito, constituindo-se como um modelo a ser replicado. A reorganização constituiu-se como uma experiência de sucesso.
Estudo de caso: Engenharia Forense e a responsabilidade civil no desabamento de três edifícios no Rio de Janeiro
Authors: Mendonça Beatriz Costa de , Mounzer Elie Chahdan
Published: August 2021

A queda do edifício Liberdade, um prédio comercial de 20 andares, fez desabar também os dois prédios ao lado, os edifícios Colombo e Treze de Maio, localizados no Centro da Cidade do Rio de Janeiro. Inicialmente o prédio não apresentava causas aparentes que fizessem culminar em sua ruína e o foco se voltou para uma obra, irregular, realizada no 9º andar. No decorrer do processo de responsabilização civil e penal, foram encontrados diversas causas que podem ter culminado no acidente. Mesmo com a realização de perícia judicial e os pareceres de diversos especialistas de engenharia, todos através de análise indireta, até a presente data não foi definida a causa do acidente. Entretanto, a responsabilização civil do síndico que permitiu diversas modificações no prédio no decorrer de décadas. A responsabilização em casos de acidentes pode recair sobre o engenheiro ou arquiteto da obra e, na ausência deste, sobre o proprietário ou síndico. O estudo conclui a importância da perícia direta em locais de acidentes, do papel da prefeitura e órgãos fiscalizadores e as mudanças nas normas infralegais relacionadas a obras e reformas após o acidente.
COVID 19 e a propagação de fake news sobre a contaminação pelo dióxido de carbono com o uso de máscaras faciais: Um estudo de reflexão
Authors: Freitag Vera Lucia , Dell'Antonio Marcos Geraldo
Published: August 2021

Objetivo: refletir sobre a propagação de fake news relacionado a contaminação pelo dióxido de carbono pelo uso de máscaras faciais em prevenção a COVID 19. Metodologia: estudo de abordagem qualitativa, exploratório e descritivo, do tipo estudo de reflexão, a partir de publicações sobre o tema e fake news sobre possíveis malefícios do uso de máscaras durante pandemia da COVID 19, a qual aflige o mundo atualmente. Ainda, busca de artigos e livros científicos. Resultados: os resultados mostraram que o uso de máscaras de qualquer natureza não tem relação à hipóxia pela suposta reabsorção do dióxido de carbono proveniente do metabolismo celular, mesmo em pessoas com comorbidades e submetidas a exercícios físicos. Conclusão: faz-se necessário que seja comprovada a eficácia do uso de máscaras, atentando para a conscientização social, desmistificando os fake news associadas à ciência, principalmente em relação a hipoxemia.
Aspectos clínicos da síndrome de Asperger na comunidade de uma universidade pública
Authors: Lindoso Anteia Galati Acioli , Sobrinho Nicaelen , Silva Rafael de Avila Justino da , Ferreira Ana Catarina de Almeida Pinho , Miranda Sheila Ferreira , Damázio Laila Cristina Moreira
Published: August 2021

A Síndrome de Asperger (SA) é um transtorno do neurodesenvolvimento que cursa com deterioração significativa nas áreas sociais, ocupacionais e outras importantes atividades do indivíduo. Os portadores da síndrome, geralmente apresentam habilidades em memorização e são bons em matemática ou ciência. A SA é uma doença recente, onde ainda existem controvérsias sobre o diagnóstico e tratamento, tendendo a ser subdiagnosticada. Objetivo: Avaliar a presença dos aspectos clínicos da SA entre estudantes, técnicos e docentes de uma universidade federal do interior de Minas Gerais, Brasil. Metodologia: A Escala Australiana para SA foi aplicada através de um questionário online e os dados dos escores foram analisados pelo teste ANOVA e o teste de correlação de Pearson, utilizando o programa estatístico GraphPrism 5.0, considerando um nível de significância de p<0,05. Resultados: O estudo permitiu evidenciar uma baixa incidência de aspectos clínicos da SA entre os docentes, discentes e técnicos da instituição, sendo que, maiores escores da escala foram encontradas entre os discentes e docentes das áreas de exatas e humanas, e os menores na área da saúde. Conclusão: A população estudada apresentou poucos aspectos clínicos para SA já que os escores mais baixos foram mais prevalentes entre os indivíduos.
Desempenho da saccharomyces cerevisiae ao estresse ácido no processo de fermentação alcoólica
Authors: Diógenes Bianca Cavalcante , Carmo Shirlene Kelly Santos
Published: August 2021

As leveduras são fundamentais para um processo fermentativo eficiente na produção de alguns alimentos e bebidas. A eficácia da fermentação depende de vários fatores, dentre eles o pH do meio. A acidez do mosto e o microrganismo fermentativo estão estreitamente ligados, desse modo, considera-se que o pH ideal para uma fermentação satisfatória, deve estar compreendido entre 4,0 e 5,0. Assim, o trabalho objetivou verificar a atuação da levedura Saccharomyces cerevisiae, quando utilizada na produção de fermentados alcoólicos em meio de estresse ácido. Para isso, as frutas tropicais foram utilizadas como matéria-prima para a fermentação alcoólica, cujo pH do mosto apresentavam-se fora da faixa adequada de operação. Ao fim, os fermentados alcoólicos produzidos foram analisados quanto as suas características físico-químicas e realizada a análise de aceitação através de análise sensorial. Os resultados mostraram que os fermentados produzidos se encontram dentro dos padrões previstos em legislação e possuem boa aceitabilidade a partir da análise sensorial, de onde se pode concluir que, a levedura utilizada apresenta eficácia na sua atividade fermentativa mesmo quando exposta ao estresse ácido.
Avaliação de indicadores de prazer e sofrimento em trabalhadores de Enfermagem Oncológica
Authors: Oliveira Alessandro Fabio de Carvalho , Teixeira Enéas Rangel , Athanázio Alcinéa Rodrigues
Published: August 2021

Objetivo: avaliar os indicadores de prazer e sofrimento psíquico vivenciados por trabalhadores de enfermagem oncológica em um hospital público do Rio de Janeiro. Metodologia: estudo prospectivo e quantitativo, sendo realizado em três unidades hospitalares de um hospital público especializado em oncologia. A coleta dos dados ocorreu através da aplicação de quatro escalas de prazer e sofrimento, que compõe o inventário sobre trabalho e risco de adoecimento, para 125 trabalhadores da área da saúde, incluindo enfermeiros, técnicos e auxiliares de enfermagem. Resultados: A maioria dos participantes eram mulheres, com idade inferior a 40 anos, formação universitária e com mais de 15 anos de experiência profissional. A avaliação do contexto de trabalho demonstrou que 94,4% dos participantes possuem uma visão moderada ou negativa das relações socioprofissionais e das condições de trabalho. Os fatores relacionados ao custo físico, cognitivo e afetivo no ambiente de trabalho foram avaliados como moderados ou graves por 95,2% dos participantes. Apesar de 96% dos participantes possuírem uma avaliação moderada ou positiva das vivências no ambiente de trabalho, a maioria deles reportaram sofrer de um desgaste físico, psicológico e social. Conclusão: A gestão hospitalar deve promover ações levando em consideração a visão dos trabalhadores de enfermagem oncológica para auxiliar no enfrentamento do sofrimento na prática hospitalar, promovendo a saúde e produtividade de toda equipe.
Social environmental vulnerability approach on the COVID-19 epoch: a case study in Blumenau (SC), Brazil
Authors: Souza Cristiane Mansur de Moraes , Mello Bruno Jandir , Florit Luciano Félix , Ramalho Ângela Maria Cavalcanti , Souza Yasmin Mansur de Moraes , Jeremias Jessica Teixeira Fraga , Aguiar Patrícia Dornelles de
Published: August 2021

There is a strong correlation between poverty indicators and the occurrence of diseases associated with environmental inequalities; therefore, it is highly necessary to explore the linkages between these inequalities and COVID- 19. This article describes a research designs made to study aspects of social environmental vulnerability that underlies the linkages between inequalities and COVID-19. This article aims to address this linkage. The objective is to explore aspects of social environmental vulnerability that underlies a case study at Blumenau, Brazil. The analysis is based on the critical question: Is there a relationship between social environmental vulnerability and COVID-19 at Blumenau? In Blumenau, where the study was carry out, the poor people are more likely to be affected from the risks arising out of the location of their homes, and this situation increases their vulnerability to floods, landslides, lack of water and exposure to open sewage. The methodology was divide into two steeps: (i) analysis of multi-temporal spread pattern of COVID-19 around the site; and (ii) analysis of the social environmental vulnerability and COVID-19 relationship. Results have shown that in Blumenau, there is a relationship between social environmental vulnerability and COVID-19. It can be said that COVID-19 emphases’ the social environmental situation in Blumenau. Based on our experience, we contend that an effective way to examine the linkages between inequalities and COVID-19 is to employ concepts and theories drawn from existing research to support guidelines, indicators and methods.
Avaliação do perfil de sensibilidade de Escherichia coli isoladas de infecção do trato urinário aos antimicrobianos
Authors: Cruz Luisa Ferreira da , Souza Israel Lucas Antunes , Souza Larissa Dias de , Cardoso Nubia da Silva , Resende Carlos Ananias Aparecido , Coelho Gustavo Nogueira , Araújo Marcelo Gonzaga de Freitas
Published: August 2021

O agente etiológico mais comumente isolado das infecções do trato urinário (ITUs) é a bactéria Escherichia coli (E. coli), a qual é responsável por cerca de 40% dos casos. Sendo microrganismos Gram-negativos, as E. coli possuem uma parede celular complexa, motivo pelo qual alguns antibióticos são menos eficazes quando comparados com sua com sua ação contra bactérias Gram-positivas. Diante disso, o objetivo deste trabalho é avaliar o perfil de sensibilidade de amostras clínicas de bactérias E. coli aos antimicrobianos usados no tratamento da ITU através do teste de difusão em ágar. Após a coleta e análise dos dados foi possível observar que a maioria dos isolados clínicos apresentou resistência a amoxicilina e foram mais sensíveis a nitrofurantoína e a cloranfenicol. A partir das informações obtidas após a análise dos dados foi possível observar que apesar do rígido controle da administração de medicamentos antimicrobianos, a incidência de bactérias resistentes a tais medicamentos é alarmante.
Políticas públicas de desenvolvimento
Authors: Araújo Amanda Beatriz Albernaz de , Pasqualetto Antônio , Pietrafesa Pedro Araújo , Beltrão Ilana Marques de Jesus
Published: August 2021

Com o fim da Segunda Guerra mundial e a dinâmica da economia, os países entraram na corrida pela disputa dentro do novo modelo globalizado. Com isso, se expandiu uma sociedade urbano-industrial, com necessidades e carecimentos politizados que se transformaram em questões públicas, necessitando de maiores intervenções do Estado, principalmente pela integração à nova ordem econômica mundial, dando ênfase na necessidade de políticas públicas para que o desenvolvimento fosse mais coeso e igualitário. Dentro desse contexto, o presente artigo é uma pesquisa exploratória bibliográfica do tipo qualitativa que objetiva o entendimento da necessidade de políticas públicas para a promoção do desenvolvimento no Brasil trazendo ações públicas importantes nesse processo como a criação das superintendências SUDENE, SUDECO, SUDESUL, SUDAM, além de base para conhecimento de termos como: desenvolvimento, espaço, região, desenvolvimento regional e desenvolvimento local. O arcabouço teórico se estrutura em autores como: Celso Furtado, Henri Lefebvre, David Harvey, dentre outros que foram encontrados nos bancos de dados: Scopus, Web of Science e Scielo. Como resultado entende-se que as políticas públicas vêm sendo discutida sua necessidade ao longo dos anos, e se mostram necessárias, mas ainda faltam muitos aprimoramentos.
Percepções sobre a atuação multiprofissional frente a COVID-19: uma revisão integrativa de literatura com estudos geriátricos
Authors: Araujo Gustavo Baroni , Afonso Thyago de Oliveira , Apolinário Joelma Maria dos Santos da Silva , Silva Mariana Pereira Barbosa , Silva Ranniely Kauany Bezerra da , Oliveira Pedro Adilon da Cruz , Barbosa Lorrane de Sousa , Lima Cézar Victor Alves de Lima
Published: August 2021

Durante a pandemia de COVID-19, os idosos (com idade cronológica de 65 anos e acima) são mais suscetíveis à infecção por SARS-CoV-2 devido à resposta alterada do sistema imunológico e à maior taxa de comorbidades subjacentes. A grande maioria das mortalidades é relatada em pacientes idosos. Assim, este estudo teve como objetivo avaliar alguns aspectos relacionados à reabilitação da COVID-19 em pacientes idosos e sua interação com multiprofissionais na área de saúde. Trata-se de uma revisão integrativa com o intuito de evidenciar a importância dos cuidados multiprofissionais aos idosos frente as condições da COVID-19. As bases de dados de literatura científica e técnicas consultadas foram: Literatura Latino-Americana e de Caribe em Ciências da Saúde (LILACS); Google Acadêmico, Scientific Electronic Library Online (SciELO). Os descritores foram selecionados a partir dos objetivos da pesquisa, sendo eles: “COVID-19” e “Idosos”. Os critérios de inclusão foram artigos completos publicados na revista entre o período de janeiro de 2019 a maio de 2021 identificados em junho de 2021. No total, 9 artigos participaram deste trabalho. Dentre os principais resultados obtidos, destaca-se a chance de envolvimento de vários órgãos governamentais e diversas profissões. Os prejuízos da COVID-19 são mais comuns em pacientes idosos, entretanto, avaliações preventivas, multidisciplinares e holísticas são essenciais para reduzir as consequências da doença. Conclui-se neste trabalho, que a adoção dos cuidados multiprofissionais para a reabilitação da saúde, juntamente com a assistência técnica destes profissionais na prevenção, representa um grande impacto na melhoria da gestão do conhecimento, qualidade do atendimento e segurança do paciente idoso.
Composição química e perfil de ácidos graxos no leite orgânico de vacas leiteiras alimentadas com microalgas (Schizochytrium limacinum)
Authors: Carneiro Neiva , Zacaron Wilson , Rossato Gabriel , Solivo Gabriela , Falk Renata Bolzan , Wagner Roger , Silva Aleksandro S. da , Zotti Claiton André
Published: August 2021

Nosso objetivo foi determinar se a suplementação de microalgas (Schizochytrium limacinum) afeta a produção diária, composição e perfil de ácidos graxos do leite orgânico. Oito vacas em lactação foram mantidas a pasto e divididas em dois grupos: as alimentadas com sabugo de milho como suplemento duas vezes ao dia durante a ordenha (CTL) e as alimentadas com sabugo de milho misturado com 100 g de microalgas (ALG) por vaca diariamente. As microalgas não afetaram a produção e composição diária do leite, mas foi observada uma tendência de redução da gordura do leite. O nível de ácido esteárico no leite de vacas alimentadas com ALG foi significativamente reduzido em 2,46 vezes, enquanto os níveis de ácido elaídico e ácido linoléico conjugado foram significativamente elevados em 3,3 vezes e 1,8 vezes, respectivamente. Uma proporção significativamente maior de PUFA: MUFA foi observada no tratamento com ALG, enquanto a proporção de MUFA: ácido graxo saturado mostrou uma tendência a aumentar (P = 0,073). Microalgas ricas em ácidos graxos ômega-3 enriquecem com sucesso o leite orgânico sem afetar negativamente a produtividade ou composição. Os consumidores podem ser atraídos para aumentar a ingestão de gordura polinsaturada ômega 3 do leite orgânico. Esses resultados podem apoiar a decisão de nutricionistas e agricultores de alimentar o gado leiteiro com microalgas, uma vez que é economicamente viável.
Perfil epidemiológico da Sífilis gestacional e sua influência na transmissão vertical no Município de Parnamirim-RN
Authors: Oliveira Júnior Severino Azevedo de , Chaves Elem Cristina Rodrigues , Santos Matheus Barbosa , Costa Ilka Lorena de Oliveira Farias , Paiva Daniele Socorro de Brito Souza , Reis Ana Paula Oliva , Mendonça Maria Helena Rodrigues de , Lima Sérgio Beltrão de Andrade
Published: August 2021

Objetivo: Analisar o perfil epidemiológico dos casos de sífilis gestacional no Município de Parnamirim – RN e os fatores predispostos à incidência da sífilis congênita, no período de 2010 a 2019. Metodologia: Estudo observacional e descritivo dos indicadores: taxa de detecção/1000 nascidos vivos da sífilis gestacional e congênita; perfil em gestantes e a situação assistencial no Pré-Natal. Resultados: Foi observada oscilação dos casos durante o período, sendo a sífilis gestacional, com máxima de 11,7/1000 em 2018 e congênita, com 2,3/1.000 em 2019. Houve maior frequência na faixa etária de 20 a 29 anos totalizando 51%, de nível fundamental incompleto (39,4%), idade gestacional de diagnóstico no terceiro trimestre (44,1%) e classificação clínica para sífilis latente (53%). Ao modelo assistencial, foi frequente à realização do Pré-Natal, com máxima de 88,5%; ao período diagnóstico no parto e pós-parto (52,9%) e, quanto ao esquema de tratamento, 76% foram inadequados. Referente ao indicador de APS apresenta decréscimo durante o período, com 61,7% para cobertura de ESF e 72,5% para AB em 2019.  Conclusão: Foi observado oscilação dos casos de sífilis, expondo lacunas no controle da doença, e falhas no modelo assistencial da Atenção Primária disposto no município, sobretudo, durante Pré-Natal, portanto, aumentando os riscos de transmissão vertical para sífilis.
Control of mildew in vines with cinnamon extract and catalase activity in organic production
Authors: Garcia Carla , Fedrigo Katiane , Gabriel André , Botelho Renato Vasconcelos , Rodrigues João Domingos , Ono Elizabeth Orika
Published: August 2021

Management with synthetic fungicides in the control of phytopathogens in viticulture can cause environmental pollution and contamination with residues in grape cluster. The objective of this study was to verify the effect of aqueous cinnamon extract on the in vitro and in vivo control of Plasmopara viticola on catalase activity on ‘Isabel Precoce’ vines. The treatments used were: aqueous cinnamon extract (ACE) at concentrations of 0.12; 0.25 and 0.50% plus 0.25% vegetable oil (VO); being the standard treatments VO (0.25%), Bordeaux mixture 1:1:100 (lime: copper sulfate: water) and water only. The germination tests of P. viticola sporangia were carried out in incubation periods of 4 and 24 hours of the pathogen in contact with the treatments. In addition, the area under the disease progress curve (AUDPC) and the activity of the catalase enzyme were estimated in plants grown in the greenhouse. The results indicated that the treatments with 0.12%, 0.25% and 0.5% ACE with VO reduced the germination of P. viticola. In relation to the AUDPC, the 0.25% dose of VO associated ACE reduced 65% and 67% in leaf discs and vines in the greenhouse, respectively. This fact is related to the induction of CAT activity provided by this dose in the periods of 2HBA, 2HAI and 4HAI. Thus, it can be said that the ACE associated with VO can be used to control the downy mildew of the ‘Isabel Precoce’ vine.
A realidade aumentada como recurso auxiliar para a aprendizagem significativa de geometria molecular
Authors: Rocha Nágila Menezes , Vasconcelos Ana Karine  Portela , Nascimento Filho Vicente Tomé do , Sampaio Caroline de Goes , Barroso Maria Cleide da Silva
Published: August 2021

O conteúdo de Geometria Molecular é visto com dificuldade pela maioria dos estudantes. Muitas vezes essa dificuldade está ligada à maneira como o assunto é abordado em sala de aula. Sabe-se que as tecnologias digitais estão cada vez mais inseridas no cotidiano dos estudantes e que podem ser utilizadas para promover um abiente favorárel para a aprendizagem, auxiliando o professor em sala de aula. Com o intuito de facilitar o entendimento e promover uma aprendizagem significativa, o presente trabalho traz como sugestão a utilização da atividade proposta pelo aplicativo de realidade aumentada Mirage-Molecular Geometry, onde o aluno tem a oportunidade compreender a geometria de algumas moléculas através da observação de sua estrutura sob diversos ângulos. Além disso, a realidade aumentada promove uma educação de forma dinâmica, possibilitando o aluno participar ativamente da construção de seu conhecimento. Sendo assim, espera-se  que a prática apresentada promova uma melhoria no processo de aprendizagem, tornando-o mais efetivo e atrativo.
Dictions Used by Religious Leaders in The Diffusion of Extension Forestry Program in Probolinggo Municipal
Authors: Tirmidi Tirmidi
Published: August 2021

An element identified as one of key points in the success of diffusion of extension forestry program, namely greening up to 6.000 hectares, was the involvement of religious leaders, especially on communicating the program to the villagers. This paper aims to describe, analyze, and interpret the dictions used by religious leaders in the program. Through a qualitative research designed in phenomenological approach, especially at naturalistic paradigm, the research found that instead of using that of semantically classified as environmental and social terms, the religous leaders preferred using that of economical terms, namely financial benefits of planting trees for the local farmers. A proposition filed from this research is: communication of innovation in the field of extention forestry program will be accepted widely and quickly by villagers when the dictions used are words that emphasize on financial benefits which might be obtained from the program.
Multimedia Development of English Learning for Recount Text Materials
Authors: Wijayanto Mochlis Eko
Published: August 2021

In this study aims to: (1) produce English learning multimedia products for recount text material, (2) find out the feasibility of English learning multimedia products for recount text material, and (3) find out the effectiveness of English learning multimedia multimedia products for recount text material for class VIII students at SMPNJ. This research method is a research and development (R&D) taken from the Alessi and Trollip model which consists of three stages, namely: (1) planning, (2) design, and (3) development. Data collection through observation, interviews, questionnaire sheets, and tests. Then, the data obtained were analyzed descriptively quantitatively. The effectiveness of the product was analyzed using the N-gain formula (normalized learning outcomes). The results of the study are as follows. (1) the products produced are multimedia in the form of English learning CDs for recount text material consisting of instructions, Competency Standards and Basic Competencies (SK and KD), description of material, summary, quiz, and evaluation; (2) the product developed is suitable for use as a complementary medium for learning English for recount text learning; (3) an increase in the average score of all students from the pretest and posttest results of 0.90 (N-gain ≥ 0.7). This means that the effectiveness of the product being developed is in the high category
Media For Language Teaching and Learning in Digital Era
Authors: Hikmah Durratul
Published: August 2021

Learning a new language is considered as difficult task because it needs more exercises in various skills. Media plays the important role in increasing the learners’ desire to learn by creating the atmosphere of fun. In this digital era, learning models utilize technology as leaning media to provide wider access and opportunities for students in building their own knowledge. The availability of technology in education enables educators to plan and implement innovative and interactive learning model.  The main goal of this paper is to suggest the current media for teaching and learning language in digital era.
The Analysis of Students’ Learning Behavior In Isolated School of SMPN Satap Tojabi
Authors: Jamilah Radhiyatul , Suryadi Ray
Published: August 2021

The research aimed to analyze the student’s learning behavior in isolated school it was conducted in a qualitative approach in SMPN SatapTojabi, Babussalam, Lasusua Sub District, North Kolaka District, South east Sulawesi it was one of the isolated schools in North KolakaDistric, located on the mountain it was about eight kilometers from the level of land with no electricity, people still used solar power for doing an activity related to electricity. The subject was the third grade students in the academic year 2019 – 2020 with 14 students. The data was collected by using observation and interview. The result showed that they gave various behaviors, some of them were diligent, obedient, and polite some of them were lazy, always messing about, and denying. By giving positive reinforcement students were not eager to get the reward even though the teacher promised a special reward some of them were still not change the behaviors. These behavior such as did not do the homework on time, messing about when their friends start to work, do not come at class on time, and keep the class noisy. While by giving negative reinforcement some students still much less discipline and less concern about their education.
Social Justice Across The English Curriculum In Indonesian Secondary Schools
Authors: Sugiono Sugiono
Published: August 2021

Social justice across curriculum is believed to entail changes in society, and thus the integration of social justice into curriculum comes to be crucial. Socially just curriculum deals with the principles of inclusive practices at schools, access to important knowledge and skills to all students, and the empowerment of students to act for socially just change. The purpose of this study was to investigate the extent to which the English curriculum in Indonesian secondary schools, year 10, is socially just.  This study focused on documentary research, analysing the collected documents – the curriculum framework and school-based curriculum development – from the lens of socially just curriculum indicators. These indicators were constructed based on the state ideology, Pancasila (Five Principles) and prominent scholars’ viewpoints of social justice covered in relevant literature.  The results showed that most of all, those documents reflected the indicators for socially just curriculum. Nevertheless, to make a judgment as to whether the English curriculum is socially just is not a simple matter, since further research, which promotes talks with teachers and students, observation of classroom activities, analysis of methods of assessment, student textbooks, workbooks, and other resources, would be necessary to be done.
Disproof of the Riemann Hypothesis
Authors: Vega Frank
Published: August 2021

Let's define $S(x) = \vartheta(x) - x$, where $\vartheta(x)$ is the Chebyshev function. We prove that the Riemann Hypothesis is false when $\int_{x}^{\infty} \frac{S(y) \times (1 + \log y)}{y^{2} \times \log^{2} y} dy \geq \frac{S(x)^{2}}{x^{2} \times \log x}$ is satisfied for some number $x \geq 121$. In addition, we demonstrate that the previous inequality is satisfied when $S(x) \geq 0$ for some number $x \geq 121$. It is known that $S(x)$ changes sign infinitely often. In this way, we show that the Riemann Hypothesis is indeed false.
Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases
Authors: Xu Yixin , Jiang Xin , Zhou Yanhong , Ma Ming , Wang Minjin , Ying Binwu
Published: August 2021

Infectious diseases are considered as a pressing challenge to global public health. Accurate and rapid diagnostics tools for early recognition of the pathogen, as well as individualized precision therapy are essential for controlling the spread of infectious diseases. Aptamers, which were screened by systematic evolution of ligands by exponential enrichment (SELEX), can bind to targets with high affinity and specificity so that have exciting potential in both diagnosis and treatment of infectious diseases. In this review, we provide a comprehensive overview of the latest development of SELEX technology and focus on the applications of aptamer-based technologies in infectious diseases, such as targeted drug-delivery, treatments and biosensors for diagnosing. The challenges and the future development in this field of clinical application will also be discussed.
An Emerging Model for Virtual International Academic Conference in Architecture, Engineering, and Construction
Authors: Fang Yanqing , Daniel Emmanuel Itodo
Published: August 2021

Academic conferences are very important to industrial development and academic scholars. However, the coronavirus disease 2019 pandemic has led to the cancellation of many international conferences; thus, virtual conferences have received a great deal of attention. Their expanding role has created an urgent need to explore the best approaches for successful execution. However, there is limited empirical evidence on the organization of these conferences. This study aims to offer a comprehensive analysis of the key success factors through a case study of the International Group for Lean Construction’s first virtual conference. The results revealed the influence of multiple factors. In addition, a successful model for an international virtual academic conference is proposed. The model contributes to the knowledge of sustainable development in engineering management and architecture, engineering, and construction practice.
Effects of Iron and Zinc on Mitochondria: Potential Mechanisms of Glaucomatous Injury
Authors: Tang Jiahui , Zhuo Yehong , Li Yiqing
Published: August 2021

Glaucoma is the most substantial cause of irreversible blinding, which is accompanied by progressive retinal ganglion cell damage. Retinal ganglion cells are energy-intensive neurons that connect the brain and retina, and depend on mitochondrial homeostasis to transduce visual information through the brain. As cofactors that regulate many metabolic signals, iron and zinc have attracted increasing attention in studies on neurons and neurodegenerative diseases. Here, we summarize the research connecting iron, zinc, neuronal mitochondria, and glaucomatous injury, with the aim of updating and expanding the current view of how retinal ganglion cells degenerate in glaucoma, which can reveal novel potential targets for neuroprotection.
On the Vernacular Language Games of an Antagonistic Online Subculture
Authors: Peeters Stijn , Tuters Marc , Willaert Tom , de Zeeuw Daniël
Published: August 2021

In this paper we develop an empirical, big data approach to analyze how alt-right vernacular concepts (such as kek and beta) were used on the notorious anonymous and ephemeral imageboard 4chan/pol/and the fan wiki Encyclopedia Dramatica. While 4chan/pol/is broadly regarded as an influential source of many of the web’s most successful memes such as Pepe the Frog, Encyclopedia Dramatica functions as a kind of satirical Wikipedia for this meme subculture, written in high concept and highly offensive vernacular style. While the site’s affordances make them distinct, they are connected by a subcultural style and politics that has recently become increasingly connected with violent right-wing activism, forming a loose subcultural language community. Contrary to “memetic” theories of cultural evolution in media studies, our analysis draws on theoretical frameworks from poststructuralist and pragmatist philosophies of language and deploys empirical techniques from corpus linguistics to consider the role of online platforms in shaping these vernacular modes of expression. This approach helps us to identify instances of vernacular innovation within these corpora from 2012-2020—a period during which the white supremacist “alt-right” movement arose online. Through these analyses we contribute both to ongoing interdisciplinary attempts to bridge the gap between cultural-theoretical and computational-linguistic approaches to studying online subcultures, and to the empirical study of the vernacular roots of the “toxic memes” that appear to be an increasingly common feature on social media.
A State-of-Art Review of Digital Technologies for the Next Generation of Tinnitus Therapeutics
Authors: Searchfield Grant D. , Sanders Philip J. , Doborjeh Zohreh , Doborjeh Maryam , Boldu Roger , Sun Kevin , Barde Amit
Published: August 2021

Background: Digital processing has enabled the development of several generations of technology for tinnitus therapy. The first digital generation was comprised of digital Hearing Aids (HAs) and personal digital music players implementing already established sound-based therapies, as well as text based information on the internet. In the second generation Smart-phone applications (apps) alone or in conjunction with HAs resulted in more therapy options for users to select from. The 3rd generation of digital tinnitus technologies began with the emergence of many novel, largely neurophysiologically-inspired, treatment theories that drove development of processing; enabled through HAs, apps, the internet and stand-alone devices. We are now of the cusp of a 4th generation that will incorporate physiological sensors, multiple transducers and AI to personalize therapies.

Aim: To review technologies that will enable the next generations of digital therapies for tinnitus.

Methods: A “state-of-the-art” review was undertaken to answer the question: what digital technology could be applied to tinnitus therapy in the next 10 years? Google Scholar and PubMed were searched for the 10-year period 2011–2021. The search strategy used the following key words: “tinnitus” and [“HA,” “personalized therapy,” “AI” (and “methods” or “applications”), “Virtual reality,” “Games,” “Sensors” and “Transducers”], and “Hearables.” Snowballing was used to expand the search from the identified papers. The results of the review were cataloged and organized into themes.

Results: This paper identified digital technologies and research on the development of smart therapies for tinnitus. AI methods that could have tinnitus applications are identified and discussed. The potential of personalized treatments and the benefits of being able to gather data in ecologically valid settings are outlined.

Conclusions: There is a huge scope for the application of digital technology to tinnitus therapy, but the uncertain mechanisms underpinning tinnitus present a challenge and many posited therapeutic approaches may not be successful. Personalized AI modeling based on biometric measures obtained through various sensor types, and assessments of individual psychology and lifestyles should result in the development of smart therapy platforms for tinnitus.
Who Participates in Content-Focused Teacher Professional Development? Evidence From a Large Scale Study
Authors: Richter Eric , Kunter Mareike , Marx Alexandra , Richter Dirk
Published: August 2021

This study investigates the relationship between teacher quality and teachers’ engagement in professional development (PD) activities using data on 229 German secondary school mathematics teachers. We assessed different aspects of teacher quality (e.g. professional knowledge, instructional quality) using a variety of measures, including standardised tests of teachers’ content knowledge, to determine what characteristics are associated with high participation in PD. The results show that teachers with higher scores for teacher quality variables take part in more content-focused PD than teachers with lower scores for these variables. This suggests that teacher learning may be subject to a Matthew effect, whereby more proficient teachers benefit more from PD than less proficient teachers.
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management
Authors: López-Nevado Marta , González-Granado Luis I. , Ruiz-García Raquel , Pleguezuelo Daniel , Cabrera-Marante Oscar , Salmón Nerea , Blanco-Lobo Pilar , Domínguez-Pinilla Nerea , Rodríguez-Pena Rebeca , Sebastián Elena , Cruz-Rojo Jaime , Olbrich Peter , Ruiz-Contreras Jesús , Paz-Artal Estela , Neth Olaf , Allende Luis M.
Published: August 2021

Primary immune regulatory disorders (PIRD) are associated with autoimmunity, autoinflammation and/or dysregulation of lymphocyte homeostasis. Autoimmune lymphoproliferative syndrome (ALPS) is a PIRD due to an apoptotic defect in Fas-FasL pathway and characterized by benign and chronic lymphoproliferation, autoimmunity and increased risk of lymphoma. Clinical manifestations and typical laboratory biomarkers of ALPS have also been found in patients with a gene defect out of the Fas-FasL pathway (ALPS-like disorders). Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), we identified more than 600 patients suffering from 24 distinct genetic defects described in the literature with an autoimmune lymphoproliferative phenotype (ALPS-like syndromes) corresponding to phenocopies of primary immunodeficiency (PID) (NRAS, KRAS), susceptibility to EBV (MAGT1, PRKCD, XIAP, SH2D1A, RASGRP1, TNFRSF9), antibody deficiency (PIK3CD gain of function (GOF), PIK3R1 loss of function (LOF), CARD11 GOF), regulatory T-cells defects (CTLA4, LRBA, STAT3 GOF, IL2RA, IL2RB, DEF6), combined immunodeficiencies (ITK, STK4), defects in intrinsic and innate immunity and predisposition to infection (STAT1 GOF, IL12RB1) and autoimmunity/autoinflammation (ADA2, TNFAIP3,TPP2, TET2). CTLA4 and LRBA patients correspond around to 50% of total ALPS-like cases. However, only 100% of CTLA4, PRKCD, TET2 and NRAS/KRAS reported patients had an ALPS-like presentation, while the autoimmunity and lymphoproliferation combination resulted rare in other genetic defects. Recurrent infections, skin lesions, enteropathy and malignancy are the most common clinical manifestations. Some approaches available for the immunological study and identification of ALPS-like patients through flow cytometry and ALPS biomarkers are provided in this work. Protein expression assays for NKG2D, XIAP, SAP, CTLA4 and LRBA deficiencies and functional studies of AKT, STAT1 and STAT3 phosphorylation, are showed as useful tests. Patients suspected to suffer from one of these disorders require rapid and correct diagnosis allowing initiation of tailored specific therapeutic strategies and monitoring thereby improving the prognosis and their quality of life.
Immune Monitoring Assay for Extracorporeal Photopheresis Treatment Optimization After Heart Transplantation
Authors: Dieterlen Maja-Theresa , Klaeske Kristin , Bernhardt Alexander A. , Borger Michael A. , Klein Sara , Garbade Jens , Lehmann Sven , Ayuk Francis Ayuketang , Reichenspurner Herrmann , Barten Markus J.
Published: August 2021

Background

Extracorporeal photopheresis (ECP) induces immunological changes that lead to a reduced risk of transplant rejection. The aim of the present study was to determine optimum conditions for ECP treatment by analyzing a variety of tolerance-inducing immune cells to optimize the treatment.

Methods

Ten ECP treatments were applied to each of 17 heart-transplant patients from month 3 to month 9 post-HTx. Blood samples were taken at baseline, three times during treatment, and four months after the last ECP treatment. The abundance of subsets of tolerance-inducing regulatory T cells (Tregs) and dendritic cells (DCs) in the samples was determined by flow cytometry. A multivariate statistical model describing the immunological status of rejection-free heart transplanted patients was used to visualize the patient-specific immunological improvement induced by ECP.

Results

All BDCA+ DC subsets (BDCA1+ DCs: p < 0.01, BDCA2+ DCs: p < 0.01, BDCA3+ DCs: p < 0.01, BDCA4+ DCs: p < 0.01) as well as total Tregs(p < 0.01) and CD39+ Tregs(p < 0.01) increased during ECP treatment, while CD62L+ Tregs decreased (p < 0.01). The cell surface expression level of BDCA1 (p < 0.01) and BDCA4 (p < 0.01) on DCs as well as of CD120b (p < 0.01) on Tregs increased during the study period, while CD62L expression on Tregs decreased significantly (p = 0.04). The cell surface expression level of BDCA2 (p = 0.47) and BDCA3 (p = 0.22) on DCs as well as of CD39 (p = 0.14) and CD147 (p = 0.08) on Tregs remained constant during the study period. A cluster analysis showed that ECP treatment led to a sustained immunological improvement.

Conclusions

We developed an immune monitoring assay for ECP treatment after heart transplantation by analyzing changes in tolerance-inducing immune cells. This assay allowed differentiation of patients who did and did not show immunological improvement. Based on these results, we propose classification criteria that may allow optimization of the duration of ECP treatment.
Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation
Authors: Mihaila Andreea C. , Ciortan Letitia , Macarie Razvan D. , Vadana Mihaela , Cecoltan Sergiu , Preda Mihai Bogdan , Hudita Ariana , Gan Ana-Maria , Jakobsson Gabriel , Tucureanu Monica M. , Barbu Elena , Balanescu Serban , Simionescu Maya , Schiopu Alexandru , Butoi Elena
Published: August 2021

Neutrophils have been classically viewed as a homogenous population. Recently, neutrophils were phenotypically classified into pro-inflammatory N1 and anti-inflammatory N2 sub-populations, but the functional differences between the two subtypes are not completely understood. We aimed to investigate the phenotypic and functional differences between N1 and N2 neutrophils, and to identify the potential contribution of the S100A9 alarmin in neutrophil polarization. We describe distinct transcriptomic profiles and functional differences between N1 and N2 neutrophils. Compared to N2, the N1 neutrophils exhibited: i) higher levels of ROS and oxidative burst, ii) increased activity of MPO and MMP-9, and iii) enhanced chemotactic response. N1 neutrophils were also characterized by elevated expression of NADPH oxidase subunits, as well as activation of the signaling molecules ERK and the p65 subunit of NF-kB. Moreover, we found that the S100A9 alarmin promotes the chemotactic and enzymatic activity of N1 neutrophils. S100A9 inhibition with a specific small-molecule blocker, reduced CCL2, CCL3 and CCL5 chemokine expression and decreased MPO and MMP-9 activity, by interfering with the NF-kB signaling pathway. Together, these findings reveal that N1 neutrophils are pro-inflammatory effectors of the innate immune response. Pharmacological blockade of S100A9 dampens the function of the pro-inflammatory N1 phenotype, promoting the alarmin as a novel target for therapeutic intervention in inflammatory diseases.
Strain-Dependent Inhibition of Erythrocyte Invasion by Monoclonal Antibodies Against Plasmodium falciparum CyRPA
Authors: Knudsen Anne S. , Björnsson Kasper H. , Bassi Maria R. , Walker Melanie R. , Kok Andreas , Cristinoi Bogdan , Jensen Anja R. , Barfod Lea
Published: August 2021

The highly conserved Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) is a key target for next-generation vaccines against blood-stage malaria. PfCyRPA constitute the core of a ternary complex, including the reticulocyte binding-like homologous protein 5 (PfRh5) and the Rh5-interacting protein (PfRipr), and is fundamental for merozoite invasion of erythrocytes. In this study, we show that monoclonal antibodies (mAbs) specific to PfCyRPA neutralize the in vitro growth of Ghanaian field isolates as well as numerous laboratory-adapted parasite lines. We identified subsets of mAbs with neutralizing activity that bind to distinct sites on PfCyRPA and that in combination potentiate the neutralizing effect. As antibody responses against multiple merozoite invasion proteins are thought to improve the efficacy of blood-stage vaccines, we also demonstrated that combinations of PfCyRPA- and PfRh5 specific mAbs act synergistically to neutralize parasite growth. Yet, we identified prominent strain-dependent neutralization potencies, which our results suggest is independent of PfCyRPA expression level and polymorphism, demonstrating the importance of addressing functional converseness when evaluating blood-stage vaccine candidates. Finally, our results suggest that blood-stage vaccine efficacy can be improved by directing the antibody response towards defined protective epitopes on multiple parasite antigens.
The Protection of Lactiplantibacillus plantarum CCFM8661 Against Benzopyrene-Induced Toxicity via Regulation of the Gut Microbiota
Authors: Yu Leilei , Zhang Lingyu , Duan Hui , Zhao Ruohan , Xiao Yue , Guo Min , Zhao Jianxin , Zhang Hao , Chen Wei , Tian Fengwei
Published: August 2021

The present study evaluated the protection of Lactiplantibacillus plantarum CCFM8661, a candidate probiotic with excellent benzopyrene (B[a]P)-binding capacity in vitro, against B[a]P-induced toxicity in the colon and brain of mice. Mice that received B[a]P alone served as the model group. Each mouse in the L. plantarum treatment groups were administered 2×109 colony forming unit (CFU) of L. plantarum strains once daily, followed by an oral dose of B[a]P at 50 mg/kg body weight. Behavior, biochemical indicators in the colon and brain tissue, and the gut microbiota composition and short-chain fatty acid (SCFA) levels in the gut were investigated. Compared to the treatment in the model group, CCFM8661 treatment effectively reduced oxidative stress in the brain, improved behavioral performance, increased intestinal barrier integrity, and alleviated histopathological changes in mice. Moreover, CCFM8661 increased the gut microbiota diversity and abundance of Ruminococcus and Lachnospiraceae and reduced the abundance of pro-inflammatory Turicibacter spp. Additionally, the production of SCFAs was significantly increased by L. plantarum CCFM8661. Our results suggest that CCFM8661 is effective against acute B[a]P-induced toxicity in mice and that it can be considered as an effective and easy dietary intervention against B[a]P toxicity.