bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Digital Marketing bagi Pelaku UMKM Pengrajin Gerabah Tanah Liat Kedungsari di Kabupaten Kediri
Authors: Santoso Agus Muji , Damayanti Bella Putri , Firdhausi Anisa Fatimatul , Lianawati Dwi , Rachmah Islamiati , Salsabela D.M. Nia Talia , Hidayati Alfiana , Aristina Vingki Dewi , Sofiananda Violyna , Agustina Hana , Yuanisyak Angga , Kusuma Irma Setiawan , Aji Abraham Dimas Bayu , Dwiyantoko Febri Nurcahyo , Sholafudin Muhamad , Annafinurika Mukhammad , Dara Made Ayu Dusea Widya
Published: March 2022

Era digital seperti sekarang ini, membuat para pelaku UMKM hendaknya bisa memanfaatkan media digital dan teknologi sebagai salah satu upaya pemasaran produknya sehingga konsumen lebih mengenal produk yang dihasilkan oleh UMKM tersebut. Tujuan program ini untuk mengetahui kendala dan respon serta pengetahuan masyarakat mengenai digital marketing. Program pelatihan dilaksanakan pada bulan Oktober 2021 dengan subjek sasaran program yaitu kelompok pengrajin gerabah di Desa Kedungsari, Kecamatan Tarokan, Kabupaten Kediri, Jawa Timur yang menjadi sentra kerajinan gerabah di Kabupaten Kediri. Tahapan program menggunakan model ODSIMED (Observation, Development, Socialization, Implementation, Monitoring, Evaluation, dan Dissemination). Hasil dari penerapan pelatihan ini terdapat peningkatan dari 14,29% pengrajin yang mengetahui digital marketing setelah pelatihan menjadi 71.43% pengrajin sudah mengetahui digital marketing.
Vamos brincar? Jogos e brincadeiras na educação
Authors: Dalmonech Jaqueline Zanotti , Dalmonech Hildo Anselmo Galter
Published: March 2022

No presente estudo tem por objetivo fazer uma reflexão teórica sobre o lúdico no cotidiano da Educação Infantil, além de averiguar de que forma os jogos e brincadeiras estão inseridos neste cotidiano no município de Santa Teresa-ES, através da aplicação de uma entrevista. O foco central é mostrar que jogos e brincadeiras são fontes impulsionadoras do processo de desenvolvimento e da aprendizagem da criança. Neste sentido, pela característica da pesquisa, buscou trazer à tona as ideias fundamentais dos diferentes papéis que tanto a brincadeira quanto o jogo exercem no fazer pedagógico da Educação Infantil. O aspecto lúdico presente no ato de brincar é essencial para a criança, uma vez que através dele ela expõe suas fantasias, desejos e emoções além de propiciar as crianças vivências primordiais para seu desenvolvimento holístico. Considerando que jogos e brincadeiras atuam positivamente no desenvolvimento da criança, se percebe a importância de os educadores resgatarem essa ludicidade em suas aulas, fazendo uso consciente dos jogos/brincadeiras.

Palavras-chave: Jogos; Brincadeiras; Educação Infantil;
Elaboração de uma sequência didática para o ensino de Cálculos Estequiométricos: aprendizagem ativa mediada pelo ensino híbrido
Authors: Ferreira Godinho Rocha Luzimary de Jesus , Dos Santos Silva Lana , Schalcher Pereira Álvaro Itaúna , Rodrigues Cruz Abias , Silva Lima Francisco Jardel , Aguiar Dutra Jose Weliton
Published: March 2022

O presente trabalho se configura como recorte da monografia intitulada Ensino de Química em Rotação por Estações: proposta de sequência didática para Cálculos Estequiométricos. O objetivo dessa pesquisa é propor uma sequência didática utilizando a Rotação por Estações para a promoção dos conceitos associados ao ensino de Cálculos Estequiométricos e desenvolvimento da autonomia intelectual dos alunos.  O estudo realizado possui uma abordagem qualitativa de caráter descritivo, onde inicialmente foi realizado um levantamento bibliográfico acerca da temática aborda para que, posteriormente, fornecesse as bases teóricas para a elaboração da sequência didática proposta.
Indicadores biológicos de qualidade do solo no assentamento Abril Vermelho, Santa Bárbara do Pará – PA
Authors: Alves Erika da Silva , De Melo Vânia Silva , Dias Marques Jonathan , Coelho Luiz Felipe Monteiro , Teixeira Orivan Maria Marques , Meyer Leandro Frederico Ferraz
Published: March 2022

O objetivo do trabalho foi avaliar por meio dos indicadores biológicos de qualidade do solo, diferentes sistemas de cobertura vegetal no Assentamento Abril Vermelho, Santa Bárbara do Pará – PA. Foram selecionadas cinco áreas: pastagem, monocultura de açaí, monocultura de mandioca, sistema agroflorestal (SAFs) e capoeira. As amostras de solo foram coletadas em agosto de 2014, em transecto de 5m x 8m, nas profundidades 0-5 cm, 5-10 cm e 10-20 cm, em trincheiras. Para cada área selecionada foram coletadas 5 amostras simples, para formar 1 amostra composta, com 4 repetições. No trabalho as variáveis avaliadas foram o carbono orgânico, e os atributos biológicos, respiração basal (RB), carbono da biomassa microbiana (CBM), quociente microbiano (CBM:C) e quociente metabólico (qCO2). Os resultados foram submetidos à análise de variância e a comparação de médias através do teste de Tukey a 5%. Os resultados indicaram que o SAFs e a pastagem apresentaram sinais de tendências à regeneração. As variáveis biológicas, CBM, RB e relação CBM:C, se apresentaram sensíveis, as mudanças no uso do solo, porém o qCO2 não apresentou a mesma resposta, demostrando que o uso de mais de uma variável é indicado.
To compare antimicrobial efficacy of a new nanosilver based endodontic irrigant in the eradication of enterococcus faecalis in comparision with 0.05% octenidine dihydrochloride and 5.25% sodium hypochlorite in infected human root denine in-vitro
Authors: Choudhary Ekta , Naqvi Sadef , Sharma Ritu , Ahmed Khaja Iftekar , Vashisht Anu , Anjum Rukhsar
Published: March 2022

Success of root canal therapy is primarly governed by the efficacy of disinfection of root canal system.Various methods, devices and irrigants have been suggested in past and are being introduced till now to have completely disinfected scenario. Still promising results are lacking.In this study we attempted to compare efficacy of nanosilver based endodontic irrigant ,0.05% octenidine solution and 5.25% sodium hypochlorite in disinfecting the root canal.
A study on health promoting services at elementary school of Jorhat Distric
Authors: Saikia Jayasree
Published: March 2022

The present study aims to reveal the entire infrastructure facilities of the elementary school in Jorhat District, and the different activities practices done by the schools for attainment of the students good health. Here health denotes the physical and mental health of the elementary school students .the study comprises four (4) elementary schools of Jorhat District.
Clinical Value of Comprehensive Nursing Intervention in Prevention of Ventilator-associated Pneumonia
Authors:   Department of Respiratory Medicine, Shandong Dongying People's Hospital, Dongying, Shandong Province, China., Liu Cuifang , Zhou Yumei ,   Pediatric Infusion Rooms, Shandong Dongying People's Hospital, Dongying, Shandong Province, China., Zhao Jingjing ,   Pediatric Infusion Rooms, Shandong Dongying People's Hospital, Dongying, Shandong Province, China., Geng Nana ,   Department of Respiratory Medicine, Shandong Dongying People's Hospital, Dongying, Shandong Province, China.
Published: March 2022

Objective: To investigate the clinical value of comprehensive nursing intervention in prevention of ventilator-associated pneumonia. Methods: From June 2018 to December 2019, a total of 116 patients who received mechanical ventilation were selected as research participants, and they were divided into control group (n=58) and observation group (n=58) according to the random number table method. In the observation group, patients were treated with comprehensive nursing, while patients in the control group were treated with conventional nursing. The mechanical ventilation time, hospitalization time, VAP incidence, psychological status, quality of life and nursing satisfaction of patients were compared in the two groups. Results: The mechanical ventilation and hospitalization time of patients in the observation group were less than those of patients in the control group, and the difference was statistically significant (P<0.05). The incidence of VAP was 3.44% in the observation group, which was lower than that in the control group (13.79%), and the difference was statistically significant (P<0.05). The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of patients in the two groups before intervention were not of statistically significant difference (P>0.05). After intervention, the SAS and SDS scores decreased in the two groups, and the scores in the observation group were significantly lower than those in the control group (P<0.05). The quality of life scores before intervention between the two groups were not statistically significant (P>0.05). After intervention, the quality of life scores in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The nursing satisfaction rate in the observation group was 94.87%, which was significantly higher than that in the control group (81.03%) (P<0.05). Conclusion: Comprehensive nursing intervention can shorten the time of mechanical ventilation and hospitalization, prevent the occurrence of VAP, alleviate the negative emotions of patients, and improve their quality of life as well as nursing satisfaction.
Psychological Care Can Reduce Pain Intensity, Relieve Negative Emotions, and Improve the Quality of Life of Patients with Advanced Gastrointestinal Cancer
Authors:   Department of Gastro-colorectal surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China, Tian Xiaofeng ,   Department of Hepatobiliary and Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China, Yang Wei ,   Department of Hepatobiliary and Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
Published: March 2022

Objective: This study aims to explore the application value of psychological care in patients with advanced gastrointestinal (GI) cancer. Methods: We randomly assigned 210 patients with advanced GI cancer treated in our hospital to receive routine care interventions (101 patients, the regular group) or to receive psychological care interventions based on the routine care (109 patients, the research group). The outcomes of care interventions in the two groups were recorded. Results: The scores of health education, ward management, care attitude, and care skills were all higher in the research group than those in the regular group (P<0.05). The two groups were not statistically different in the visual analog scale (VAS) score before intervention (P>0.05). After intervention, the VAS score markedly decreased in both groups, with lower VAS scores in the research group than in the regular group (P<0.05). In both groups, the scores of the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) after intervention were lower than those before intervention (P<0.05). After intervention, the SAS and SDS scores were markedly lower in the research group than in the regular group (P<0.05). After intervention, the Self-perceived Burden Scale (SPBS) score decreased in both groups, with markedly lower SPBS scores in the research group than in the regular group (P<0.05). The score of the EORTC Quality of Life Questionnaire Core 30 (QLQ-C30) increased in both groups after intervention, with higher QLQ-C30 scores in the research group than in the regular group (P<0.05). The care compliance rate and the care satisfaction level were higher in the research group than in the regular group (P<0.05). Conclusion: Psychological care can remarkably relieve the negative emotions of patients with advanced GI cancer, enhance the care quality, improve the quality of life of patients, and reduce the self-perceived burden of patients.
Safeguarding Student Privacy in Schools
Authors: Doyle Miranda
Published: March 2022

Schools have always collected data on their students - everything from grades and test scores to information about behavior and medical issues. Beginning in March 2020, however, the potential for unwanted sharing of student information exploded. Most schools without existing 1-to-1 technology programs, where every student is assigned a digital device, scrambled to hand out laptops, Chromebooks, or iPads to students. Schools also tried out and adopted digital teaching tools such as Google Classroom, Canvas, Clever, Pear Deck, Flipgrid, Edpuzzle, Screencastify, Explain Everything, Kahoot!, GoNoodle, and many others. The COVID-19 pandemic pushed many schools fully online. Now, with schools back to in-person learning, school activities still often depend on the use of these digital devices and tools.

School administrators must consider the digital rights of these students and families as they choose resources. It's also important for parents, teachers, school librarians, and the broader community to know the types of data that schools and their third-party vendors collect, and what they can do to better protect that data.
Poykayil Appachan’s interventions for Dalit Liberation in Kerala
Authors: R Chandrabose
Published: March 2022

Poykayil Yohannan, better known as Poykayil Appachan and Sreekumar Gurudevan (1879-1939) was one of the unparalleled renaissance heroes in the history of Kerala. He made various and intellectual contributions for the liberation of the Dalit people of Kerala through songs, Bible commentaries and social activities. This paper explores his physical and spiritual work for the upliftment of Dalit people and his role in the construction of Kerala Renaissance. Without the backing of formal education or scholarship, he gained knowledge from life experiences, learn to read and write on his own, overcame adversity and became a social reformer. Liberating Dalit people with his eloquence and rational analysis skill.
Covid-19 and housing struggles: The (re)makings of austerity, disaster capitalism, and the no return to normal
Authors:   RHJ Editorial Collective
Published: March 2022

Seemingly overnight, the use value of housing as a life-nurturing, safe place is at the center of political discourse, policy-making, and new governmentalities. The right to suitable and secure shelter has shifted from the “radical” margins to the object of unprecedented public policy interventions worldwide. Writing collectively from the relative privilege of our (often precarious) homes, we sketch out a space to reflect on the centrality of housing and home to the Covid-19 crisis, to disentangle the key nexus between housing, the aftermath of the 2008 crisis, austerity, and the current pandemic, and connect current responses to longer-term trajectories of dispossession and disposability, bordering, ethno-nationalism, financialization, imperialism, capitalism, patriarchy, and racism. We argue that much is to be learned from collective organizing and mutual aid in the context of previous moments of disaster capitalism.
ASLIDO: Association of People for Homes, Czech Republic
Authors:   Asociace lidí pro domov, z.s.
Published: March 2022

Asociace lidí pro domov (ASLIDO) is a group of people who have experienced homelessness and their allies in the Czech Republic. We work to make spaces that allow us, people with experiences of homelessness, to take part in the process of decision making regarding laws and policies that directly influence our lives. In our work, we use the theatre of the oppressed method.
Reporting from Greece
Authors:   Stop Auctions Athens, Katerini Tonia
Published: March 2022

Greece is now at the forefront of a new housing crisis because the mechanisms of housing acquisition through the market are no longer functioning. This has been exacerbated by austerity measures put in place after the last crisis, in 2008. There are three main problems in this moment: large numbers of indebted people who are in danger of losing their homes, the increasing cost of rents because of the spread of Airbnb, and the lack of policies for social housing. The movement for the right to housing has been fighting for the last six years to protect indebted families from losing their houses through auctions that are taking place every week. Over the last two years, the movement has increasingly fought against Airbnb’s control of the rental market and for the protection of the tenants’ rights. We have also put on the agenda the need to repurpose the thousands of empty buildings that exist in Greece for social housing.
SECURING TEXT MESSAGE WITHIN A VIDEO USING LSB STEGANOGRAPHY AND RSA ALGORITHM
Authors:   Gitam University ,Visakhapatnam., Reddy S C Yalla , Abhishek N , Vardhan R Sai , Jagannadh V , Karthika G
Published: March 2022

The Internet is the media because of which it is feasible to move information from one spot to somewhere else with exceptionally rapid. Be that as it may, it is exceptionally unsafe to move information over the web. Thus to keep up with protection and to keep an unapproved individual from extricating data steganography procedure is utilized. Steganography is the study of hiding restricted data. The restricted data is as text, picture, sound and video. This restricted data can be hiding in the text, picture, sound and video. Hiding privileged intel in a video document is called video steganography. In this task, one of the most outstanding secure steganography procedures (LSB) is introduced. With the development in advanced correspondence advances and the fast development of network transmission capacity, the Internet has ended up being an ordinarily involved channel for sending many reports for example, sound, video, picture, and message in advanced structure. Many practices have been offered and produced for giving the protected transmission of information. The focal point of the ebb and flow research is on the plan of data hiding procedures utilized for sending restricted information where computerized pictures are chosen as the cover-media. This part has distinguished the issues in the present picture steganography plans.
A Review Paper on Big Data and Hadoop is solution for Big Data
Authors:   Sipna College of Engineering and Technology, Amravati, Maharashtra, Bhuyar Apurva A.
Published: March 2022

The amount of data produced and communicated over Internet is significantly increased. The formation of this massive amount of data through divergent source is massive. Now days a Big Data application where data collection has grown very fast and traditional software tools are unable to capture, manage, and process it. In this paper we are highlighting Big Data its sources and types such as structured, unstructured and semi structured. Data is generated from various different sources and can arrive in the system at various rates. In order to process these large amounts of data in an inexpensive and efficient way, parallelism is used. Big Data is a data whose scale, diversity, and complexity require new architecture to manage it and extract value and hidden knowledge from it. Hadoop is an open source software project that enables the distributed processing of large data sets across clusters of commodity servers. It is designed to scale up from a single server to thousands of machines, with a very high degree of fault tolerance.
Impact of COVID-19 Pandemic on Impulsive Buying Behaviour for Domestic Brands
Authors:   Lal Bahadur Shastri Institute of Technology and Management, Indore, Bhawsar Shruti Dholi
Published: March 2022

Consumers' lifestyles and shopping patterns are disrupted by pandemics like COVID-19, which has a negative influence on the global economy. Consumer purchases of a country's own brand and products created in that country contribute significantly to that country's GDP and aid in the recovery of that country's economy. During the first phase of the corona virus lockdown citizens in India faced unique scenarios, resulting in an unexpected shift in consumer preferences. The goal of this research is to identify what factors influence a consumer's buying behaviour while making a brand purchase decision, and to apply linear regression model to figure out what those factors are. Consumers have started preferring the value of cleanliness in products, environmentally friendly products, regional (local) products, and satisfaction beyond shopping during the pandemic. According to the findings of this study, these aspects determine their desire to buy Indian brands and items made-in-India. Furthermore, following the lockdown and the COVID era, customers believe that purchasing Indian-made products and encouraging others to do so will positively benefit and revitalise the Indian economy. The findings of this study can help marketing managers to develop proper promotion techniques to encourage ethnocentric tendencies, and cues can be offered to elicit a sense of economic nationalism in customers when they buy products or services. Keywords: global economy, ethnocentric tendencies, impulsive buying behaviour, purchase decision
FLY ASH GENERATION-UTILIZATION, GOVERNMENT INITIATIVES IN INDIA AND OTHER DIVERSE APPLICATIONS: A REVIEW
Authors: Sharma Rekha , Yadav R. N.
Published: March 2022

The dynamic economic growth, robust growth of industrialization and expanding population are the key factors responsible for significant increases in global energy demand. The Power sectors account for almost 74% of coal consumption in India. The Indian coal is characterized by low calorific value (3000-3500 k. cal.) and very high ash content (30-45 %). Thus, huge amount of fly ash is being generated every year as “waste by product” in coal-based power plants. Hence in present scenario, the safe management and eco-friendly utilization of this surplus fly ash generated has become a global challenge. Due to the serious efforts of ‘Fly Ash Mission’ of India, the utilization level of fly ash has progressively improved from 11.68 % in 1998-99 to 77.59 % in 2018-19. This review presents state wise status of fly ash generation-utilization, government initiatives in India and other new domains of potential fly ash applications.
PREBIOTICS AND SALMONELLOSIS: ROLE OF FRUCTOOLIGOSACCHARIDES AND INULIN
Authors: Pal Anindita Deb
Published: March 2022

Salmonellosis is a worldwide concern emerging as one of the key causes of global diarrheal disorders. Salmonella enterica var Enteritidis and Typhimurium are the two most common serovars associated with potent foodborne illnesses followed by S Enterica Newport and Heidelberg, leading to major economic losses in the food industry. Numerous approaches have been employed for prevention and treatment of the same. Recent studies have highlighted the role of prebiotics in control of the disease. Fructose-based prebiotics including fructooligosaccharides and inulin have been shown to influence the occurrence, progression, severity as well as overall pathogenesis of Salmonellosis. These compounds protect host health via inhibition of pathogen colonization and translocation along with hastened elimination of the microbe. Moreover, these oligosaccharides also improve intestinal histology and alter inflammatory cascades. Indeed, these compounds have been implicated in TGF-β and PPAR-ϒ mediated downregulation of NF-κB dependent inflammation. The effectiveness of these prebiotics is enhanced by stimulation of probiotic dependent increase in short chain fatty acids, anti-microbial compounds as well as antioxidant enzymes. Administration of these fructose-based oligosaccharides have been shown to improve prognosis in human cells, poultry, swine, and certain mice models. Nonetheless, the deleterious effects of the above have also been reported in rodents. The combined efficacy of these prebiotics is therefore dependent of a variety of external and internal factors. A complete understanding of the above may help in generation of novel approaches for combating Salmonella infection.
A REVIEW ON FIRST MEMBERS OF COVID-19 VACCINES IN PHASE 3 AROUND THE GLOBE
Authors: Sharan Mahek , Kamthania Mohit
Published: March 2022

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a member of the coronaviridae family is the cause of the pandemic which started in 2019 and the world is still fighting against it. In spite of the usage of drugs like remedesivir, flavinavir and hydroxycholoquine along with different approaches to increase the immunity or to treat the respiratory infection in humans, even now this viral infection is uncontrollable. According to the stats, till November 10, 2020 over 10 million people have lost their lives around the world, touching the mark of 37 mill ion plus patients around the world with epidemiology showing the most cases in USA followed by India, Russia, Brazil and Spain. After seeing the rapid spread and post disease effects of this air borne viral infection, an urgent need of the vaccine consider ed. This led to encourage researchers around the world to develop different types of vaccines, namely inactivated, live attenuated, nanoparticle based, viral vectored, recombinant type, DNA and RNA vaccines, among which few have already passed Phase 1 clinical trials and are under Phase 2 or 3 human trials. The vaccines which have the highest potential to be successful with minimal side effects proposed by different countries around the world with their type, mechanism of action and their effects along with the challenges and considerations regarded with these vaccines has been discussed in this paper.
DESIGN AND MOLECULAR DOCKING STUDIES OF PIPERIDIN-4-ONE DERIVATIVE AS ACTIVE AGENT AGAINST HELICOBACTER PYLORI INFECTION
Authors: J. Winfred Jebaraj , T. Sasitha
Published: March 2022

Helicobacter pylori is one of the most common bacterial pathogens in the world and is an important global public health concern. Half of the world populations are seriously infected by Helicobacter pylori. In India, approximately 80% of the population is infected with the bacterium Helicobacter pylori by the age of 20. Among those, hundreds of millions of people are affected by peptic ulcer disease during their lifetime and tens of millions might develop to gastric cancer. Helicobacter pylori infections are very difficult to cure. This present work is aimed to find the solutions to overcome this problem. Black pepper is used to cure ulcer since it has piperine which has piperidin moiety. Piperidin-4-one is one of the most biological active moieties, used as drug. In the present work, more than thirty eight thousand, 2,6-diphenyl piperidone derivatives are theoretically designed and docked with 2B7N protein of Helicobacter pylori. PyRx virtual screening is used to dock protein with ligand to find lead molecules. The best docking piperidones are selected and their drug likeness properties are predicted computationally. Finally best lead molecule is identified.
PHYTOCHEMICAL AND ANTIMICROBIAL ACTIVITY OF THE LEAVES OF CROTON BONPLANDIANUM BAIL
Authors: Basak Goutam Kumar , Chowdhury Tanmay , Chakraborty Susama , Karmakar Ankana , Mandal Amitava
Published: March 2022

Plants are always been the sources of medicine from prehistoric ages. Croton bonplandianum Bail. is an exotic weed of Euphorbiaceae family. It has medicinal use in folk medicinal practices. Herein, we report the antibacterial activities of the leaf extracts of croton against some antibiotic resistance bacteria and have isolated stigmasterol as the active component. Structure of stigmasterol was established from detailed spectral analyses (IR, NMR, etc.). The leaf extracts showed promising antibacterial activities and could be a suitable alternative against antibiotic resistance bacteria.
EPIDEMIOLOGICAL CHARACTERISTICS OF FEMALE BREAST CANCER PATIENTS OF SAURASTRA REGION OF GUJARAT-A HOSPITAL BASED STUDY
Authors: Mehta Priya , Patel Vaibhavi , Rawat Seema , Pathak Rakesh Ranjan , Gupta V. K. , Patel Prabhudas , Goswami Girish K.
Published: March 2022

With the increase in adoption of westernization and sedentary life style in low- and middle-income countries like India, there is a significant increase in breast cancer incidence rate. The exact cause of breast cancer is yet unknown and there are limited studies available on the risk factors associated with breast cancer. Thus, this research work is carried out with an aim to study the region-specific contributing risk factors playing role in breast cancer incidence and their prognosis. We also aimed to study rural-urban disparity in risk factors associated with female breast cancer patients of Saurastra region of Gujarat. This Cross Sectional, Single-Centre, Hospital-based study was conducted in Cancer Hospital at Rajkot, Gujarat India. One-to-one In-person interview of total 174 primary breast cancer patients were carried out and details were collected in pre-tested structured questionnaire. Data obtained from the patients were further analysed using Bürkner’s BRMS package (R) interface and SPSS. In our study, majority of patients are from rural background and its subsequent relationship with other relevant parameters is found to be significant (p less than 0.03). The age of patients ranged from 22 to 76 years and the mean age at diagnosis of the breast cancer was 51.5 years. A positive association is observed between risk of breast cancer and BMI for both pre- and post-menopausal rural and urban women. 37% females were having premenopausal status and 62% females were postmenopausal. Out of total postmenopausal patients, 31% had attained late menopause at the age of 51 years, while 13% females had experienced menarche at less than 12 years of age. Our data is first of its kind studying risk factors playing role in breast cancer incidence in Saurashtra region of Gujarat. Even though having limited patients representing the population this region-specific study is useful for cancer projection and to understand treatment modalities.
FORMULATION AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) OF COMMIPHORA WIGHTTI EXTRACT
Authors: Singh Mahendra Kumar , Singh Mahendra Pratap , Jain Alok Pal , Lokesh Kavita R.
Published: March 2022

Commiphora mukul widely known as Guggul herb is highly used by the rural and tribal people for curing various disorders. Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones. Herbal formulations have growing demand in the world market. In the present study an attempt was made to formulate and develop self emulsifying drug delivery system (SEDDS) of methanolic extract of Commiphora wightti (guggul) and to enhance its solubility, dissolution and its bioavailability. The solubility of guggul extract was determined in various oil, surfactant and co-surfactants. Pseudoternary Phase diagram were used for optimization of microemulsion formulation. The prepared formulations of SEDDS were evaluated based on their in-vitro drug release profile, globule size, zeta potential and self emulsifying assessment. In vitro release studies of optimized formulation F3 revealed that release profiles of SEDDS of guggul extract was best expressed by Higuchi equation, as the plots showed highest linearity (coefficient of determination, R2=0.993). It was observed that the optimized SEDDS formulation F3 showed 98.14 % release at 60 min.
COMPARATIVE STUDY ON THE PHYSICOCHEMICAL CHARACTERISTICS OF PENAEUS MONODON CULTURE PONDS ALONG THE SOUTH EAST COAST OF TAMIL NADU
Authors: Chandrakala N. , Parameswari P.
Published: March 2022

Marine shrimp farming is a century-old practice in many Asian countries. Until a decade ago, this commodity was generally considered a secondary crop in traditional fish farming practices. In the traditional farming system, the ponds are stocked with fry either collected from the wild or concentrated through tidal water entering the ponds. Some improvements of the traditional farming methods have been made in the past years. In Aquaculture quality of water is one of the most important factors. The various physic chemical parameters of the unaffected and outbreak shrimp culture ponds were analysed. The parameters such as the pH and COD were significantly high (p≥5). But the salinity, DO, BOD, Calcium, Chloride, nitrate, phosphate 8#x38; iron of the unaffected and outbreak ponds were significantly low (p≤ 5). Bacteria analysis of the unaffected ponds was very low but the outbreak ponds showed enormously higher counts. The blue green algae and Diatoms of unaffected and outbreak ponds were found to be significantly low (p≤ 5).
BIOLOGICAL ACTIVITY OF FLUORESCENT COPPER COMPLEX: SYNTHESIS, CRYSTAL STRUCTURE, DFT AND PROTEIN BINDING STUDY
Authors: Sahoo Gobinda Prasad , Pandey Akhil , Hazra Madhumita , Patra Animesh
Published: March 2022

Synthesis of square planar copper (II) complex with formula [Cu (DMAP)2(NCS)2] (1) (DMAP =N,N-dimethyl-4 aminopyridine) was done and characterized by various spectroscopic and single-crystal X-ray diffraction study. Complex 1 crystallizes in the monoclinic space group, P 21/c, with cell dimensions a = 6.066(2), b = 10.702(4), c = 14.561(5) Å, a = 90 b = 93.11(2) and c = 90. The electron transfer mechanism of copper (II) complex was measured by cyclic voltammetry and indicate copper (II) complex is the Cu(II)/Cu(I) couple. The electronic structure and spectral properties of the complex-1 has been explained by density functional theory (DFT) and time dependent density functional theory (TDDFT) calculations. In-vitro, human serum albumin (HSA) binding was also carried out using absorption and fluorescence technique, which showed considerable binding affinities of the complex with HSA. Again we report the synthesis of copper complex-HSA microcrystals. The complex has been screened for antimicrobial activity by agar disk diffusion and minimum inhibitory concentration (MIC) strain against some pathogenic bacteria.
DESIGN, SYNTHESIS AND 3D-QSAR STUDIES OF NEW BIS (INDOLYL) METHANES AS ANTIOXIDANT AGENTS
Authors: Bahe A. K. , Naikoo G. A. , Raghuvansi J. , Kosti P. , Das R. , Mishra M. , Hassan I. U. , Kashaw S. K.
Published: March 2022

The reaction of indoles with aromatic aldehydes in the presence of 5 mol% p-toluenesulfonic acid as a catalyst in acetonitrile media afforded high yields of bis(indolyl)methane via conventional and ultrasonication methodologies. It was observed that the ultrasonication method produced a higher yield of products in shorter reaction times. All synthesized compounds were evaluated for their antioxidant activities. Among them, compounds 3a, 3f, 3g, 3j, 3k, 3p, 3q and 3t showed moderate to good antioxidant activity. 3D-QSAR analysis was performed to the obtained compounds and investigated using comparative molecular field analysis (CoMFA) method, helping to better understand the structural requirements of lead compounds with high antioxidant activity and biological compatibility.
INFLUENCE OF BARIUM METAL IN ORGANIC CRYSTAL OF BCTU BY VARIOUS CHARACTERISATION STUDIES
Authors: Subha V. , Mariappan M. , Selvarajan G.
Published: March 2022

A pure transparent solid organic crystal of Barium chloride Thiourea Urea (BCTU) was obtained at room temperature by using distilled water following the method of slow evaporation technique. The optical property of the crystal was studied by UV-Vis spectral study. The functional groups were identified by FT-IR spectral analysis. The crystals structure was characterized by XRD analysis. The thermal stability of the crystal was evaluated by thermo gravimetric and differential thermal analysis (TG-DTA). The microhardness also confirmed the stability of the crystal by the Vickers method.
A STUDY ON THE CORROSION INHIBITION PROPERTIES OF MACROTYLOMA UNIFLORUM (HORSE GRAM) ON MILD STEEL
Authors: Parameshwari S. , Reddy Babu , Srinivas Padaki
Published: March 2022

In this research work, the seed extract of the lentil, Macrotyloma uniflorum (Horse gram) was used for the study of corrosion inhibition on mild streel in 0.1 M HCl. The experimental study was done using the method of weight loss at various temperatures. It was found that as the volume of seed extract increased, the inhibitor efficiency also increased drastically. The same behavior was observed at different temperatures also.
VERSATILE APPLICATIONS OF THE IONIC LIQUID
Authors: Saha Sudipta
Published: March 2022

The first ionic liquid Ethyl ammonium nitrate was discovered in the year 1914. Ionic liquids are organic salt that is composed of organic cations and organic or inorganic anions. Ionic liquids subsist as liquid below the 100˚C or in the room temperature. A huge number of ionic liquid can be synthesized by the amalgamation of the various anions and cations through numerous kind of bonds. Ionic liquids are considered as green solvents because of non-volatility, lowviscosity, colourless, polar, wide range of solubility of biopolymers, absorption and desorption of gases. The environmental factor (E-factor), atom efficiency also supported the greenness of the ionic liquid. In chemistry, ionic liquid can replace the usual volatile organic solvents, mineral acids, solid acids etc., due to the non-corrosive green nature. For this reason, ionic liquids can be employed to numerous organic syntheses. The synthesis of ionic liquids can be done in single or multiple steps. Microwave irradiations and ultrasound assisted reactions are commonly employed to synthesise the green ionic liquids. Purification of ionic liquids can be done through crystallisation, extraction, distillation, biphasic separation and also through composed method of centrifugation or membrane separation followed by distillation. Broadly, ionic liquids are classified as basic ionic liquids, protic ionic liquids, neutral ionic liquids, chiral ionic liquids, metallic ionic liquids, poly ionic liquids, bio-ionic liquids, task specific ionic liquids etc. The major application of ionic liquids in the field of solvents and catalysts, electrochemistry, physical chemistry, analytical chemistry, pharmaceutical, biological, engineering field is well documented in this paper.
AN OVERVIEW ON RECENT ADVANCEMENT METHODS AND CHARACTERIZATION OF NANOFIBER TECHNOLOGY
Authors: Mantha Arun Kumar , Kukati Latha , Shaik Naseeb Basha , Sheerin Arshiya , Devasari Manasa , Adepu Shirisha
Published: March 2022

This paper highlights the unique features and a brief introduction to the Nanofiber production methods, characterization and their potential applications. Nanofibers are made from various materials and have been used for a wide range of applications such as reinforcement fibers in composites, protective clothing, filtration, biomedical devices, electrical and optical applications, and nanosensors. Nanofibers with controlled diameters range from Nanometer to Micrometer which possess unique properties like a high surface area- to-volume ratio, low density and high pore volume. These properties make nanofibers more advantageous. The most widely used techniques are electro spinning and electro spunning methods. The potential uses for the different nanofiber technology was identified and many of the techniques are still in the developmental stage, but some of them are already fulfilling fledgy roles in the fields of biomedical and industry. Other issues encounters in the technology limitations, research challenges, and future trends are also discussed in the article.
SUSTAINED RELEASE APPROACHES TOWARDS THE CHEMOTHERAPY OF TUBERCULOSIS
Authors: Shubham Sharma , Nidhi Dubey
Published: March 2022

Tuberculosis is a most important killer of young adults worldwide and the global blight of multi-drug resistant tuberculosis is reaching epidemic proportions. It is endemic in most developing countries and resurgent in developed and developing countries with high rates of human immune insufficiency virus infection. This article reviews the current situation in terms of drug delivery approaches for tuberculosis chemotherapy. A number of novel implant, microparticulate and a variety of other carrier-based drug delivery systems incorporating the principal anti-tuberculosis agents have been made-up that either target the site of tuberculosis infection or reduce the dosing occurrence with the aim of improving patient outcomes. These developments in drug delivery represent attractive options with noteworthy merit, on the other hand, there is a necessity to manufacture an oral system, which directly addresses issues of unacceptable rifampicin bioavailability in fixed-dose combinations. This is fostered by the need to deliver medications to patients more efficiently and with fewer side effects, especially in developing countries. The fabrication of a polymeric once-daily oral multi particulate fixed-dose combination of the principal anti-tuberculosis drugs, which attains segregated delivery of rifampicin and isoniazid for improved rifampicin bioavailability, could be a step in the right direction in addressing issues of treatment failure due to patient non-compliance.
CLINICO-RADIOLOGICAL CORRELATION AND OUTCOME OF COVID-19 PATIENTS PRESENTING TO A L2 CENTRE IN WESTERN UTTAR PRADESH
Authors: Khan Nafees Ahmad , Firdaus Huma , . Arushi , Krishnan Gishnu , Anwar Hahzad , Arif Mohammad , Shameem Mohammad , Bhargava Rakesh
Published: March 2022

Objective of the current study was to evaluate the clinical features and severity of chest x-ray and its association with outcome in patients of Covid-19 in terms of hospital stay, discharge or death during hospital stay. A total of 100 patients above the age of 15 years diagnosed with Covid-19 by RT PCR of nasopharyngeal/oropharyngeal samples were included in the study. History of symptoms at onset was recorded, Chest-x-ray and hematological investigations were done. Chest x-ray findings were divided into three zones upper, middle and lower and each zone was given a score. Each zone involvement of either lung was given a score of 1. Maximum score was 6 with involvement of all zones of both lungs and minimum score was zero in patients with normal chest x-ray. These patients were followed up during their hospital stay in terms of oxygen requirement, Non invasive ventilation (NIV) requirement, Invasive mechanical ventilation, number of days of hospital stay and the outcome in terms of discharge or expired. Among the total of 100 patients, 58 were male and 42 were female patients. Maximum numbers of patients were in age group 45-60 years. Most common presenting complaint was fever followed by shortness of breath. Most common co morbidity was diabetes mellitus. We found that hypoxia at presentation, rate of intubation, and mortality was highest in patients with higher chest x-ray score and minimum in patients with chest x-ray score of zero. Discharge rate was highest in patient in lowest chest x-ray score. We conclude from the current study that chest x-ray score at the time of presentation has a predictive role in determining the risk of intubation and outcome in patients of covid-19.
DETECTION OF MYCOBACTERIUM TUBERCULOSIS AND DRUG RESISTANCE IN PEDIATRIC PATIENTS SUSCEPTED OF PLEURAL TUBERCULOSIS
Authors: Sharma Gaurav , Malhotra Bharti , John P. J. , Bhargava Shipra
Published: March 2022

The main purpose of this study is the detection of Mycobacterium tuberculosis (MTB) and its drug resistance profile by molecular methods in pediatric patients suspected of pleural tuberculosis. Children ≤ 15 years of age suspected of pleuritis were enrolled in this study. Total 176 pleural fluid samples were collected from January to June 2018 and tested for AFB microscopy, GeneXpert and MGIT culture. Of 176 samples, total 14 (8%) samples were positive for MTB and 1 (7.1%) was observed MDR-TB. Smear microscopy detected AFB in 2 (1.1%) cases only. GeneXpert and MGIT culture showed 6 (3.4%) and 12 (6.8%) positive cases respectively, out of, 1 (16.7%) was found rifampicin resistant by GeneXpert. Of culture positives, 1 (8.3%) was MDR-TB 8 1 (8.3%) was found isoniazid mono-resistant by first line LPA. Sensitivity and specificity of GeneXpert by using MGIT culture as gold standard was found to be 33.3% and 98.8% respectively. MDR-TB observed by GeneXpert was 16.7%. Among 12 culture positive isolates, only one (8.3%) isolate was found MDR-TB and one (8.3%) was isoniazid mono-resistant. Results of Geno Type MTBDRsl assay showed that only one (50%) isolate was fluoroquinolones resistant and sensitive to second line injectable drugs. None of the isolate was Extensively Drug Resistant (XDR). GeneXpert can provide rapid immediate diagnosis of MTB and rifampicin resistant which can help in giving proper treatment but simultaneous culture also needs to be done as it missed many cases. It’s important to look for drug resistance as 16.7% isolates were rifampicin resistant.
ADSORPTIVE REMOVAL OF MALACHITE GREEN DYE FROM AQUEOUS SOLUTION USING A NON CARBON ADSORBENT: EQUILIBRIUM, KINETICS AND THERMODYNAMICS
Authors: Patidar Divya , Goyal Swati
Published: March 2022

In this paper, studies for the removal of malachite green dye from aqueous solution using adsorption technique are presented. There are different adsorbent available for malachite green dye removal from water effluents. Hence, the recent literature in the area is categorized according to the cost, feasibility, and availability of adsorbents. An extensive survey of the adsorbents, derived from various sources such as low-cost biological materials, waste material from industry, agricultural waste, polymers, clays, nano-materials, and magnetic materials, has been carried out. Adsorbent unsaturated polyester resin is case effective for the removal of malachite green dye from aqueous solution. The research paper studies different adsorption factors, such as pH, concentration, adsorbent dose, contact time, temperature. The fitting of the adsorption data to various models, isotherms, kinetic and thermodynamic parameter is also reported.
ANTIDIABETIC ACTIVITY OF HEART WOOD OF PTEROCARPUS MARSUPIUM ROXB. IN ALLOXAN INDUCED DIABETIC RATS
Authors: Bais Nidhi , Choudhary Gajendra Pratap , Dubey Nidhi
Published: March 2022

Diabetes mellitus is most common disease which is leading cause of morbidity and mortality among Indian population. Pterocarpus marsupium is a medicinal plant used in ayurvedic medicine system to control blood sugar. The aim of this study was to determine antidiabetic effect of mixture of ethanolic extract of heartwood of Pterocarpus marsupium. To evaluate antidiabetic activity, extract was administered in experimental mice and significant decrease in blood glucose level was shown on 7th day. Histopathology was also studied. Thus from present study it can be concluded that pterocarpus marsupium extract has antidiabetic activity in alloxan induced diabetic rat.
ADSORPTION OF HEXAVALENT CHROMIUM BY ACTIVATED CARBON MERREMIA EMARGINATA (ACME) FROM SYNTHETIC AQUEOUS SOLUTIONS
Authors: Krishnamoorthi Kalpana , Shanmugam Arivoli , Murugan2 Ajithkumar
Published: March 2022

In this study, preparation of adsorbent from Merremia emarginata stem and its application for adsorption of chromium (VI) from aqueous solution was studied. The batch adsorption experiments were carried out to study the effect of contact time, adsorbent dose, effect of pH and effect of other ionic concentration on the removal of chromium (VI) by activated carbon. The equilibrium adsorption data were analyzed by Freundlich and Langmuir isotherm models. The thermodynamic parameters such as change in free energy (ΔG°), enthalpy (ΔH°) and entropy (ΔS°) were determined. Kinetic modeling of the process of removal was carried out and the process of removal was found to follow a pseudo second order model, Elovich model and Intraparticle diffusion model the value of rate constant for adsorption process was calculated. This study indicated that activated carbon Merremia emarginata, which is inexpensive, has efficiency to remove chromium (VI) from aqueous solution.