bluuebunny/crossref_metadata_2025 huggingface dataset:
Productivity and Profitability of chickpea as Influenced by varying levels of phosphorus and Bio-fertilizers under sub-tropical conditions of Madhya Pradesh
Authors: Parashar Aman , Sharma Jaidev , Parveen Shama , Kanaujiya Pradeep Kumar
Published: July 2024

Afield experiment was conducted at the Crop Research Centre of School of Agriculture, ITM University, Gwalior, (M.P.) during Rabi 2021–22 and 2022–23 to study the influence of phosphorus and bio-fertilizers on productivity and profitability of summer black gram under sub-tropical condition of Madhya Pradesh. The experiment was laid out in factorial randomized block design by taking four levels of phosphorusviz. 0 kg P2 O5 ha-1, 30 kg P2 O5 ha-1, 40 kg P2 O5 ha-1, 50 kg P2 O5 ha-1 and bio-fertilizers (No inoculation, PSB, Rhizobium, PSB + Rhizobium which were replicated thrice. The chickpea variety “JG-16” was uniformly fertilized by 20 kg N/ha through Urea. However, phosphorus and bio-fertilizers were applied as per the requirement of the treatments. The crop was managed as per the recommended package and practices. The experimental study revealed that among the phosphorus levels, the application of 50 kg P/ha recorded significantly high seed and stover yield. However, among the bio-fertilizers, application of Phosphate solubilizing bacteria + Rhizobium resulted in highest seed and stover yield of chickpea. Among the economic analysis, application of 50 kg ha-1 phosphorus and combined treatment of Phosphate solubilizing bacteria+ Rhizobium incurred the highest cost of cultivation, highest gross return, net return and Benefit cost ratio. Therefore, for chickpea cultivation, application of 50kg ha-1 phosphorus and treatment of Phosphate solubilizing bacteria+ Rhizobium was proved to be profitable.
Decisiones acertadas en Endocrinología
Authors: Giraldo Manuel , Levinson Wendy
Published: July 2024

Choosing Wisely (CW) es una campaña dirigida por médicos comprometidos a ayudar a pacientes y profesionales de la medicina a entablar conversaciones sobre la atención innecesaria. Ha aumentado la concienciación sobre el problema del uso excesivo o las intervenciones de escaso valor en procedimientos diagnósticos y tratamientos médicos. Este movimiento internacional comenzó en Estados Unidos en 2012 y en Canadá en 2014. La campaña involucra a médicos y otros profesionales de la salud, como enfermería, odontología, medicina de laboratorio y farmacia, entre otros. También se compromete con los estudiantes de medicina para ayudarles a establecer buenas prácticas al principio de sus carreras. En la actualidad, la campaña se ha extendido a 35 países, entre ellos Brasil, Colombia y Argentina, que se unieron en octubre de 2023.
En Colombia, bajo el liderazgo de la Asociación Colombiana de Sociedades Científicas (ACSC), 11 sociedades científicas, entre ellas ACE, se han unido a "Decisiones Acertadas" desde su creación. La lista de recomendaciones de pruebas y medicamentos innecesarios que ACE ha dado a conocer apoya la fuerte evidencia de que la atención de bajo valor puede conducir a eventos adversos o pruebas adicionales, lo que puede aumentar la ansiedad de los pacientes y cuidadores y aumentar la probabilidad de falsos positivos u otros daños prevenibles. Por ejemplo, la ACE recomienda que los niveles de vitamina D no se soliciten de forma rutinaria en la población general, porque esta medición no cambia la gestión. Otras recomendaciones se refieren al uso excesivo de la ecografía tiroidea, la medición de la insulina basal y los marcadores óseos en la osteoporosis, así como a limitar la utilidad de prescribir vitamina D a pacientes con factores de riesgo específicos de deficiencia.
Decisiones acertadas y la autorregulación médica
Authors: Bernal Ocampo Dora Patricia
Published: July 2024

“Decisiones acertadas” es una iniciativa de autorregulación de la profesión médica que es totalmente consistente con el artículo 17 de la Ley Estatutaria, la cual establece la autonomía de la profesión, pero con autorregulación.
La Asociación Colombiana de Sociedades Científicas adopta la iniciativa como mecanismo para concretar acciones de autorregulación, aprovechando este espacio que ha abierto la Ley Estatutaria, porque es una manera de demostrarle a la sociedad que las organizaciones médicas estamos preocupadas por la autorregulación, la cual tiene un efecto muy importante: el de contribuir a la preservación de la confianza de la sociedad en sus médicos.
Esta iniciativa corresponde a una de mayor alcance a nivel internacional, que comenzó en Estados Unidos en el año 2012, “Choosing Wisely”, y que se ha difundido por diversos países del mundo. En la actualidad, más de 30 naciones han adoptado esta misma propuesta con otros nombres, pero con el mismo contenido y sentido: generar recomendaciones acerca de conductas médicas que se deben cuestionar o que se deben eliminar, ya sea porque no hay evidencia de que funcionen o porque hay evidencia de que hacen daño. Siempre basado en la mejor evidencia disponible.
Chasing the ‘Ghost’ of Entopia: Doxiadis, Ekistics, and Placemaking in Cities
Authors: Major Mark , Atour Raya , John Deepthi
Published: July 2024

Constantinos A. Doxiadis was a leading architectural and urban theorist during the 20th century. At the dawn of the Information Age, he renewed the call for a science of human settlements, which he termed ekistics. Current debate inevitably revolves around his legacy in the field. The present article briefly reviews Doxiadis’ thinking about settlements and science. Focusing on the state of ekistics thinking today, our analysis is based on the case study of Metropolitan Athens and the Attica Region in Greece using space syntax. WE explore the inherent potentials and pitfalls of Doxiadis’ conception of ecumenopolis - a type of world city –, arguing that it remains too abstract and impractical of an idea for today’s world. Nonetheless, Doxiadis’ intellectual legacy is profound. We conclude that architects, urban designers, and town planners should continue to develop Doxiadis’ ideas about dynapolis (dynamic city) and entopia (in place) when addressing placemaking in cities for people today and tomorrow.
Reflections on Doxiadis’ Theory of Planning for Human Settlements
Authors: Lai Lawrence Wai Chung
Published: July 2024

This short paper reflects on why C.A. Doxiadis’ theory of planning for human settlements is a good theory that is human-centred, bottom-up, multi-disciplinary, as well as a practical tool backed by a clear model with unambiguous criteria or measures that can articulate with other tools for planning an open society in a complex world.  Within the context of recent commentaries on his theory, practice and teaching, the reflections are based on eight research papers by Doxiadis from which the salient features of his theory are presented with evidence adduced in the form of quotes from his papers according to his viewpoints on history, value, and the science of and action for human settlements.
Megalopolis Revisited: Reflections on Gottmann, Doxiadis, and the Northeastern United States
Authors: Bromley Ray
Published: July 2024

The term megalopolis, derived from the Greek language, has been used for over 2,400 years to signify ‘great city’ or ‘giant city.’ It was first applied as a placename in Ancient Greece, but its primary application on the global scene began in the late 1950s when the French geographer Jean Gottmann wrote a major book on the urbanized northeast of the United States, the corridor from Boston to New York, Philadelphia, Baltimore, and Washington D.C., conceiving the region as an integrated whole called Megalopolis. At that time this region was perhaps the most populous, and certainly the most prosperous, giant conurbation in the world—the pivotal center of the post-World War II global system. Subsequently the term megalopolis was built into Constantinos Doxiadis’ typology of past, present, and future human settlements, acquiring a global significance and many potential applications in other world regions. With over 60 years of hindsight, this paper reviews Gottmann’s Megalopolis as a regional monograph. It also discusses the collaboration between Gottmann and Doxiadis, and Gottmann’s transition from describing a specific geographical region to conceptualizing major polynuclear urban agglomerations with 25 to 100 million inhabitants in different parts of the world.
Compatibility Study of Fenofibrate with Some Common Excipients and Their Effect on Solid Doge Formulation Development
Authors: Pawar Prajakta Arun , Sinha Vivek Ranjan , Yadav Ashok Kumar
Published: July 2024

Objective: Through fenofibrate (Fen) and excipient compatibility assessments and the development of Fen pellets, the current study aims to discover suitable excipients to improve performance and stability of oral solid formulations. Methods: Analytical instruments [Differential Scanning Calorimetry – Q20, TA Instruments, Fourier Transform Infrared Spectroscopy Spectrum RX 1, Bruker Advance Neo 500MHz Nuclear Magnetic Resonance Spectrometer, and Thin Layer Chromatography)] were used to characterize Fen and to study the compatibility. Excipients and Fen were obtained from Loba chemie and Biocon, correspondingly. USP1-type dissolution apparatus was used to study the dissolution, and Auto Dock VINA 1.2.0 software was utilized to know the interaction of Fen with different excipients. Results: Different analytical techniques confirmed that Fen was compatible with used excipients. Docking score for combination of Fen with microcrystalline cellulose (MCC) was found -2.3 and it showed minimum interaction with each other. Additionally, an instant release of Fen tablet was deliberated utilizing a combination of various excipients. Maximum drug release (93.03% in 60min) was obtained with physical mixture of Fen and MCC. Tablet batches 1, 2 and 3 showed 94%, 88% and 87% percent drug release respectively at 90min. It was observed that batch 1 displayed extreme drug release and lowest disintegration time. Conclusion: From several analytical procedures, it was discovered that Fen was compatible with excipients used in pharmaceutical manufacturing, including lactose, magnesium stearate, MCC, talc, dicalcium phosphate, and mannitol. Physical mixture of MCC with Fen disclosed extreme amount of % drug release in shorter period. Docking studies displayed possible interactions among Fen and excipients. It was observed that Fen was more soluble when combined with the microcrystalline complex. Developed immediate release tablets demonstrated fast disintegration and drug release.
Gestão dos recursos hídricos na bacia hidrográfica do rio Munim: gerenciamento do comitê de bacia hidrográfica
Authors: Mendes Jonas Jansen , Guandique Manuel Enrique Gamero , Rodrigues José Nicollas Pereira , Martins Geovana Camara , Barroso Filipe da Cruz , Mendes Georgina Jansen , Chaves Narla dos Reis Bacelar , Diniz Dayse Gabriela Barbosa
Published: July 2024

A diversidade de interesses nos recursos hídricos coloca em risco a disponibilidade, a oferta e a escassez das águas, sendo de relevante interesse a investigação, por meio dos instrumentos e indicadores de gerenciamento desse recurso natural. O uso dos recursos hídricos utilizados de forma insustentável tem colaborado para o desenvolvimento de conflitos entre os múltiplos usuários de água. Como estratégia para mediar esses conflitos, propõe-se a gestão dos recursos hídricos, no intuito de assegurar a disponibilidade desse patrimônio natural. Sendo assim, a presente pesquisa tem o objetivo de compreender a gestão dos recursos hídricos do rio Munim – MA, a partir do gerenciamento do comitê de bacia hidrográfica. Como procedimento metodológico foi realizado pesquisas bibliográficas, elaboração de material cartográfico, pesquisas de campo, onde buscou avaliar a gestão do comitê no período de 11/2019 a 11/2021, além da aplicação de questionários para 32 dos 50 membros possíveis, composto por 5 questões abertas e 5 fechadas, totalizando 10 questões para a identificação da capacidade da gestão dos recursos hídricos. Os resultados revelaram que a ação do comitê de bacia hidrográfica é considerada insuficiente por seus membros, por falta de recursos financeiros, má gestão ou baixa efetividade dos membros participantes, o que resulta em desafios para efetividade do comitê de bacia hidrográfica. Tais resultados mostraram que 50% dos membros consideram a gestão do CBH como insuficiente, o que pode ser indício da falta de recursos financeiros, má gestão ou baixa efetividade dos membros participantes, além disso os indicadores mostraram como uma forma de avaliar a gestão das águas no âmbito municipal por meio dos quais se identificou que a maioria dos municípios ainda não possuem ferramentas adequadas de organização das ações que realizam na bacia hidrográfica, refletindo na sistematização de práticas de proteção e conservação dos recursos hídricos, no entanto, estes indicadores proporcionaram uma análise integrada de fatores naturais, estruturais, formas de uso e os conflitos que ocorrem em uma bacia hidrográfica, colaborando para a indicação de modelos sustentáveis de desenvolvimento, formas de uso e ocupação da terra e a conservação ambiental.
O laboratório didático (remoto) de ciências: “velhos” funda-mentos, novas reflexões
Authors: Oliveira Isabela Dutra de , Caetano Thiago Costa , Rezende Júnior Mikael Frank
Published: July 2024

A utilização de atividades experimentais no ensino de Física tem sido destacada há tempos na literatura especializada e, apesar da reconhecida importância, é sabido da limitada ou nenhuma utilização dessas atividades em sala de aula. Esse comportamento recalcitrante tem sido atribuído a fatores como falta de formação específica dos docentes, falta de estrutura adequada nas escolas,  turmas superlotadas, tempo escasso alocado para as aulas de ciências, problemas de gestão escolar, etc. Inúmeras alternativas a essas limitações foram surgindo na medida em que o avanço tecnológico ocorria e, com o advento mais recente das atividades experimentais didáticas de física controladas remotamente, com suas especificidades e contextos, e que ganharam novos contornos a partir dos desdobramentos da pandemia de COVID-19, percebeu-se a necessidade de revisitar alguns dos aspectos de uma discussão já estabelecida sobre os Laboratórios Didáticos de Física por Alves Filho (2000), e lançar o olhar sobre algumas das particularidades apresentadas pelos Laboratórios Remotos à luz de cinco pontos principais: 1) a necessidade que os estudantes possuem do concreto, de tentarem “enxergar” os fenômenos físicos e seus efeitos; 2) o desenvolvimento da capacidade de questionamento por parte dos estudantes; 3) o desenvolvimento de certas habilidades e competências generalizáveis; 4) a oportunidade de cotejar concepções alternativas que os estudantes possuem, e 5) o fato de que os estudantes gostam do trabalho prático e do ambiente descontraído do laboratório. Assim, este trabalho consiste em uma análise inicial para identificar evidências sobre os Laboratórios Remotos e a viabilidade de aproximações a construções teóricas já estabelecidas sobre essa temática.
Experiências exitosas de oficinas integrativas do PET-Saúde Interprofissionalidade para formação e trabalho colaborativo em saúde
Authors: Poletto Patrícia Rios , Silva Carla Cilene Baptista da , Garbus Rafaela Barroso de Souza Costa , Marques Daniela Crescente Arantes Araujo , Aveiro Mariana Chaves , Uchôa-Figueiredo Lúcia da Rocha , Chriguer Rosangela Soares
Published: July 2024

O presente artigo tem como objetivo relatar as experiências exitosas desenvolvidas em encontros formativos, com todos os participantes integrantes do projeto do Programa de Educação para o Trabalho para a Saúde (PET-Saúde) Interprofissionalidade. No olhar ampliado, percebe-se que o binômio saúde e educação afeta o trabalho e a formação em saúde, respectivamente e, a educação permanente do preceptor interprofissional e o desenvolvimento docente interprofissional são de suma importância, pois eles são o elo entre a formação de novos profissionais, a educação permanente  e a prática. Os encontros de Educação Permanente em Saúde foram realizados por meio de oficinas integrativas intituladas ‘Diálogos sobre Interprofissionalidade’, além de refletir sobre seus significados e aprendizagens à luz da literatura científica. O relato evidencia a importância das discussões dos fundamentos da Educação Interprofissional em Saúde (EIP) na formação. As vivências possibilitaram o fortalecimento da interação entre os atores com a construção de vínculos afetivos e de aprendizagem, a consolidação do conhecimento sobre a EIP e a prática colaborativa, o estímulo à participação ativa e interativa dos saberes e vivências e a experimentação de teoria de aprendizagem que dialoga com a EIP. Além disso, o formato de aprendizagem da Oficina Integrativa foi incorporado pela coordenadora do Núcleo de Educação Permanente em Saúde de São Vicente, também preceptora do PET-Saúde, nos encontros de educação permanente desenvolvidos na Secretaria de Saúde junto aos servidores. Assim, a partir do relatado e discutido reitera-se que programas como o PET-Saúde continuam tendo potencial para induzir mudanças na formação e no fortalecimento da integração ensino-serviço-comunidade. Espera-se com isto contribuir para a inovação em educação em saúde e na formação de novos profissionais.
Aplicação da biópsia líquida no diagnóstico de neoplasias em cães: uma abordagem integrativa
Authors: Teixeira Sarah Fernandes , Jadjescki Caio Alexssander Ramiro , Aguiar Trystan Nascimento de , Castro Fernanda Cristina de Abreu Quintela , Barcelos Rafael Mazioli , Rossoni Junior Joamyr Victor , Ambrósio Roberta Passamani , Santos Tatiani Bellettini dos , Chiarelli Neto Orlando , Chiepe Kelly Cristina Mota Braga , Lemos Clécio , Batista-Silva Hemily , Loyola Yolanda Christina de Sousa , Ronchi Silas Nascimento , Marcolongo-Pereira Clairton
Published: July 2024

Introdução: O câncer é uma das principais causas de mortalidade em seres humanos e animais de companhia, destacando a necessidade de métodos diagnósticos mais eficazes. As biópsias tradicionais são invasivas e não capturam a heterogeneidade tumoral ao longo do tempo. A biópsia líquida, uma técnica minimamente invasiva que detecta DNA tumoral circulante (ctDNA) no sangue, oferece monitoramento em tempo real e maior precisão diagnóstica. Objetivo: Explorar a aplicação da biópsia líquida como método diagnóstico para neoplasia em cães, no contexto da medicina de precisão. Metodologia: Realizou-se uma revisão integrativa nas bases de dados Scielo, PubMed e Google Acadêmico, analisando artigos originais em inglês publicados até abril de 2024. Utilizaram-se as palavras-chave "liquid biopsy" e "dog". Foram excluídos artigos fora da temática, análises em células, material em língua não inglesa, editoriais e revisões. Avaliaram-se número de cães analisados, tipo de amostra, tipo de câncer, técnica empregada e achados principais. Resultados: A revisão incluiu 33 artigos relevantes, com a maioria publicada entre 2022 e 2023. O plasma foi a matriz mais analisada. Os tipos de câncer mais investigados foram os tumores mamários. A biópsia líquida demonstrou capacidade de detectar câncer em estágio inicial, monitorar a resposta ao tratamento e identificar mutações relevantes para a terapia. Conclusão: A biópsia líquida é uma ferramenta promissora para o diagnóstico precoce de câncer em cães, oferecendo uma alternativa menos invasiva às biópsias tradicionais. Esta técnica permite um monitoramento contínuo das alterações tumorais, melhorando a precisão diagnóstica e o planejamento terapêutico, contribuindo para o bem-estar animal.
Resgate do conhecimento tradicional: atividade antimicrobiana de Lippia origanoides Kunth. (Verbenaceae) frente à Staphylococcus sp. causadores de mastite bovina
Authors: Fernandes Magda , Santos Renan Felipe Silva , Linden Laís Albuquerque van der , Chagas Maíra Maria Meira , Lucena Raíssa Coutinho de , Farias Eulina Tereza Nery , Mota Rinaldo Aparecido , Abad Atzel Candido Acosta , Araújo Daniel Rodrigo Cavalcante , Lima Evilda Rodrigues de
Published: July 2024

A mastite é a enfermidade que acarreta maior prejuízo em rebanhos leiteiros. O uso de extrato de plantas para tratamento da mastite já é utilizado a fim de reduzir o uso indiscriminado dos antimicrobianos. A Lippia origanoides é uma planta rica em substâncias bioativas e possuem potencial antimicrobiano comprovado por diversos autores. Encontra-se amplamente distribuída, de forma endêmica, na caatinga brasileira. O objetivo do trabalho foi avaliar a composição fitoquímica e a atividade antimicrobiana do extrato de Lippia origanoides frente a bactérias do gênero Staphylococcus sp. isoladas de mastite em bovinos. A metodologia foi baseada em analisar a ação do extrato vegetativo da planta sob o formato de extrato hidroalcoólico em diferentes concentrações. Após a obtenção da planta, foi elaborado em laboratório o extrato hidroalcóolico final. Na busca pela composição fitoquímica presentes no extrato e sua concentração, foi realizada uma análise de cromatografia líquida de alta eficiência. A atividade antimicrobiana do extrato foi avaliada pela técnica de microdiluição em caldo, sendo possível observar a reação bacteriana frente à disposição do extrato em diferentes concentrações. Ao fim, os antibióticos convencionais foram testados, pelo teste de disco difusão, buscando definir tolerância bacteriana ao fármaco e ao composto. A análise fitoquímica revelou três compostos majoritários que pertencem ao grupo dos flavonoides. O extrato apresentou atividade antibacteriana frente a todas as amostras testadas, com concentração inibitória mínima e concentração bactericida mínima variando de 187,5 a 1.500 µg/mL. No teste de disco-difusão foi observado maior índice de resistência para o beta lactâmico penicilina, além de resistência aos antibióticos penicilina, tetraciclina, eritromicina, clindamicina e cefoxitina. O extrato da L. origanoides possui alto teor de flavonoides e mostrou resultado promissor como composto antibacteriano.
The question of seasonal markets in Bronze Age Attab, Sudan
Authors: Budka Julia
Published: July 2024

The question of seasonal markets in Bronze Age Attab, Sudan

The multidisciplinary ERC Consolidator Grant project DiverseNile explores a crucial part of northern Sudan as a case study to reconstruct Bronze Age biographies (c. 1750–1200 BCE) beyond the present cultural categories ‘Egyptian’ and ‘Nubian’. The main hypothesis that is addressed by interdisciplinary methods is that degrees of cultural diversity become archaeologically more visible in the peripheral zones of urban sites.
A pioneering multi-omics data platform sheds light on the understanding of biological systems
Authors: Canela Núria Anela
Published: July 2024

A pioneering multi-omics data platform sheds light on the understanding of biological systems

The GLOMICAVE project has developed an innovative multi-omics data analysis digital platform, relying on big data analytics and artificial intelligence and using large-scale publicly available and experimental omic datasets. The project aimed to maximise the utility of omic data at a massive level and discover new links between animal and vegetable genotype and phenotype, understanding biological systems as a whole.
Pengungkapan Standar GRI Terhadap Kinerja Sosial dalam Penyusunan Laporan Keberlanjutan di Instansi Pemerintah Daerah
Authors: Yusuf Bastiar  , Syaiful Rahman Soenaria
Published: July 2024

This study examines the disclosure of GRI Standards on sosial performance in the preparation of sustainability reports in Local Government Agencies. Through a special method of Action Research. This method is by requesting data from people who have the capacity in the Bandung City Government. The results showed that the GRI 2021 Standards that have been included in the Bandung City government's sustainability report regarding general disclosures and material topics as well as specific disclosures regarding the impact of sosial aspects. In the sosial aspect, human rights are not violated and there are no cases or complaints to the Bandung City Government regarding human rights issues. In the human rights aspect, with various policies and programs established, such as strengthening human rights protection institutions, training for law enforcement officers, as well as advocacy and community education, the Bandung City Government seeks to ensure that the basic rights of every individual are respected and protected. The Bandung City Government has not yet produced a sustainability report that uses the comprehensive option based on GRI Standards 2021.
PROSES MAINTENANCE DAN EVALUASI KINERJA POMPA 56-P-101 D DI UNIT UTILITIES PT. XYZ
Authors: Vialin Antero Jona , Kurniawan Ahmad , Nugroho Bayu Fajar , Ardiansyah Dika , Hidayat Rahmat , Purnama Rizky Candra , Paundra Fajar
Published: July 2024

Pompa merupakan salah satu jenis mesin fluida yang berfungsi untuk memindahkan zat cair dari suatu tempat ke tempat yang diinginkan. Zat cair tersebut contohnya adalah air, oli atau minyak pelumas, serta fluida lainnya. Pada Perusahaan XYZ pompa jenis 56-P-101 D di unit utilities sangat sering dioperasikan dalam mengolah produk-produk di perusahaan XYZ sehingga perlu diterapkan perawatan terhadap pompa demi menjaga agar pompa tetap terawat sehingga usia pakai dari pompa dapat bertahan lebih lama dan dapat minimalisir kerusakan yang mungkin dapat terjadi pada pompa . Penelitian ini bertujuan untuk menganalisis penggunaan pompa dalam konteks cooling tower di industri minyak bumi, dengan fokus pada operasi dan pemeliharaan di fasilitas XYZ. Metode yang digunakan dalam pengambilan data penelitian ini adalah metode observasi. Metode observasi melibatkan pengamatan langsung terhadap suatu fenomena atau kegiatan untuk mengumpulkan data. Dalam hal ini, informasi tentang unit 56 dikumpulkan dengan cara mencatat aktivitas, peristiwa, atau parameter yang relevan dalam log sheet secara langsung dari operasional lapangan. Implementasi dari penelitian ini mencakup peningkatan keberlanjutan operasi industri minyak bumi dan peningkatan efisiensi energi secara keseluruhan.
PERHITUNGAN RESIDUAL LIFE ASSESMENT (RLA) DENGAN MENGGUNAKAN METODE ULTRASONIC TESTING (UT) TERHADAP HASIL INSPEKSI PADA PIPELINE GAS DI PT. XYZ
Authors: Firjatullah Suhaeri Muhammad , Saputra I Gede Riyan Oka , Ariyasa I Made Wijana Dwipa , Hafidh Muhammad Maulana Al , Abidin Mohamad Riza , Aziz Muhammad Farouq Abdul , Fajar Paundra
Published: July 2024

Inspeksi merupakan upaya mendeteksi dan memperbaiki kondisi tidak aman di tempat kerja untuk mencegah kecelakaan. Tujuan inspeksi adalah mengidentifikasi bahaya potensial, menilai resiko, dan mengendalikan keselamatan. Alasan dilakukannya inspeksi antara lain untuk keselamatan, kualitas, kepatuhan, perawatan, dan pengujian produk. Kecelakaan kerja disebabkan oleh keadaan tidak aman, tindakan tidak aman, dan interaksi manusia dengan lingkungan kerja. Inspeksi pipeline menggunakan metode ultrasonic testing untuk mengamati kerusakan akibat fluida. Residual Life Assessment digunakan untuk mengevaluasi sisa umur peralatan. Metode UT memeriksa ketebalan pipa dengan empat titik pengukuran. APD seperti helm dan sarung tangan digunakan untuk mengurangi risiko kecelakaan. Proses pengambilan data harus teliti dan lengkap.
Exploring the Link between Obesity and Hypothyroidism
Authors: Khan Salman , Rehman Abdur , Zubair Muhammad , Shah Naseeb ur Rehman , Khan Nisar
Published: July 2024

The association between obesity and hypothyroidism has garnered significant attention due to their overlapping prevalence and potential bidirectional relationship. Objectives: To investigate the link between obesity and hypothyroidism in local population of Pakistan. Methods: A cross-sectional study conducted at Medical Unit DHQ Teaching Hospital in Dera Ismail Khan from 2022 to 2023 involved 550 participants. Demographic characteristics, age, gender, clinical parameters, body mass index (BMI), comorbidities, and thyroid blood tests (TSH, T4) were collected through systematically designed questionnaire. Lifestyle factors, dietary habits, physical activity and medication history were also recorded. Electronic medical records were reviewed to collect demographic information and medication history. Results: Data from 550 participants, meeting inclusion/ exclusion criteria, showed that individuals with hypothyroidism had a lower mean age (42.5 ± 8.6 years) than obese counterparts without hypothyroidism (45.2 ± 9.8 years). The odds ratio (OR) for the association between obesity and hypothyroidism was 2.45 (95% CI: 1.75 - 3.42), indicating a significant positive correlation (p < 0.001). Family history of thyroid disorders was present in 24.0% of individuals with subclinical hypothyroidism and 20.5% without. Mean BMI was higher in individuals with subclinical hypothyroidism (29.3 ± 3.5 kg/m2) than those without (27.8 ± 2.9 kg/m2). Conclusions: Our study confirmed obesity's strong link to hypothyroidism, especially in females, stressing the need for thyroid evaluation in obese individuals, particularly in clinical settings
After 20 Years of Treatment with Aprepitant for Chemotherapy-Induced Nausea and Vomiting, Should the Therapeutic Indications for Aprepitant be Expanded?
Authors: Mehboob Riffat , Munoz Miguel
Published: July 2024

The drug aprepitant, a selective antagonist of the neurokinin-1 receptor (NK-1R), was approved in 2004 by the FDA for the treatment of CINV, blocking the activation of the receptor by substance P (SP). Oral aprepitant (day 1:125 mg; days 2-3: 80 mg) (low doses) was coadministered with dexamethasone and a serotonin 5-HT3 receptor antagonist. The aprepitant triple regimen is effective for the prevention of CINV in patients being treated with moderately or highly emetogenic chemotherapy [1]. Furthermore, activation of the SP/NK-1R system has been reported to mediate also pruritus and cough.  A study published on 17 patients with skin T-cell lymphomas (CTCL) with refractory pruritus was treated with aprepitant administered according to the standard of 125–80–80 mg either in a weekly or a biweekly repetition regimen. They show that aprepitant was safe, well tolerated and effective for the treatment of severe chronic pruritus in patients with CTCL [2]. In addition, two randomized clinical trials have clearly demonstrated that aprepitant (day 1:125 mg; 2-7/2-3: 80 mg) suppresses treatment-refractory cough in patients with lung cancer [3,4]. Regarding safety, NK-1R antagonist aprepitant was safe and well tolerated. In a placebo-controlled trial in patients with moderate-to-severe major depression, a dose of 300 mg/day (moderate doses) of aprepitant was well tolerated and no statistically significant difference in the frequency of adverse events was observed as compared with placebo. Additionally, aprepitant was as antidepressant as paroxetine [5]. Furthermore, in the las 20 years has been reported many papers about the involvement of SP/NK-1R in cancer progression and the use of NK-1R antagonist aprepitant counteract all the pathophysiological functions of SP related to cancer. In fact, aprepitant is a broad-spectrum antitumor drug. Obviously, the concentrations or doses of aprepitant to have antitumor activity are higher (20-40 mg/kg/day) (high doses) [6].
In conclusion, based on the safety (low and moderate doses) and efficacy of aprepitant, its use in refractory pruritus with CTCL and treatment-refractory cough in patients with lung cancer should be approved. Regarding cancer treatment (high doses) we suggest the initiation of a Phase I clinical trial to see what safe doses are and Phase II clinical trials to evaluate the efficacy of aprepitant alone or in combination therapy with chemotherapy or radiotherapy at least in tumors with the poor prognosis.
Factors related to H. pylori infection in Nablus region: cross sectional analysis from west bank
Authors: Najajra Duha , Awwad Mahdi , Natour Nihal , Kharraz Lubna , Alnees Mohammad
Published: July 2024

H. pylori infection is common infection in developing countries and is associated with gastric and extra-gastric complications was not studied before in Occupied Palestinian territories. We wanted to measure the prevalence of H. pylori infection in a sample from Nablus region in West Bank and to study risk factors and clinical outcomes. We found that 122 patients who visited medical laboratories in Nablus were recruited to participate in the study.  A questionnaire was collected from the study group on information that included; demographic variables, diseases history, blood groups.  A sample of stool was collected and evaluated for H. pylori  infection using H. pylori Antigen Test. SPSS software was used to perform statistical analysis of the study.  41.8% of the study participants had H. pylori infection. Patients without Diabetes mellitus type were less likely to have H. pylori  infection (OR= 0.15(95% CI, 0.04, 0.60, p=0.008).  Also, not having GI was associated with less H. pylori infection OR= 0.40, 95% CI, 0.39, 1.75, p=0.018).  H. pylori infection was more common in patients with O blood group, but this did not reach statistical significance.  Smoking and hygiene practices were not related to H. pylori infection. In conclusion, H. pylori infection is prevalent in Nablus and is associated with higher risk for Diabetes and GI problems.
Modelling the Formation of NO, NO2, CO2 and CO During Natural Gas Combustion in High-temperature Heating Chamber
Authors: Skrzyniarz Magdalena ,   Faculty of Production Engineering and Materials Technology, Czestochowa University of Technology, Armii Krajowej 19, Częstochowa, 42-200, Poland, Zub Julia , Królikowski Wojciech , Stachurski Wiktor , Gałązka Dominik , Morel Sławomir , Zajemska Monika
Published: July 2024

The article presents the results of computer simulations of the formation of selected natural gas combustion products in a high-temperature heating chamber, which is a model of a pusher heating furnace. Calculations were performed using the licensed ANSYS CHEMKIN-PRO software. The mechanism selected for the calculations was one of the most commonly employed chemical mechanisms for methane combustion, namely GRI-Mech 3.0. The calculations were based on the perfectly stirred reactor (PSR). The result of the calculations was an estimation of the influence of the temperature and residence time on the chemical composition of the exhaust gases, in particular undesirable combustion products such as NO, NO2, CO2 and CO. The obtained results of numerical calculations can constitute the basis for diagnostics of the combustion process in terms of emitted pollutants, and may also be useful in taking actions aimed at optimizing the entire combustion process. Knowledge of the mechanisms of pollutant formation may also play an important role in the energy use of process gases, including those from the thermal conversion of waste.
ARTIFICIAL INTELLIGENCEAND ARMS CONTROL
Authors: Adil Sultan Warisha Rashid
Published: July 2024

The emergence of artificial intelligence has brought new challenges and opportunities to the global arms control regime. Integration of AI into military systems can complicate states’ security matrix, due to its speed and accuracy, with additional problems of distinguishability, integration, and accountability. AI can be a useful tool to enhance transparency in verification measures for an effective arms control treaty. Arms control for the regulation or limiting use in military systems is as important as the use of AI for improving the arms control regime. The integration of AI in arms control is not without its pitfalls; it offers several new opportunities. Its use could help address some of the anxieties that prevent states from willingly engaging in an arms control agreements. These developments are important because of the shortcomings in global arms control treaties, and regional rivals like India and Pakistan. AI intergration could incentive the South Asian nuclear neighbours to maintain strategic stability.
DIGITALIZATION OF THE RUSSIAN ECONOMY: PROBLEMS AND PROSPECTS
Authors: Билык Т.Х.
Published: July 2024

Целью статьи является анализ проблемных аспектов и перспективных направлений развития цифровой экономики в России. Показано, что российская стратегия развития цифровых технологий в значительной мере соответствует мировым тенденциям, однако процессы цифровизации в России затруднены наличием барьеров, которые проявляются в недостаточном уровне цифровой готовности, дефиците компетентных кадров для цифровой экономики, правовых и нормативных барьерах, финансовых ограничениях, низкой эффективности распределения ресурсов при внедрении информационно-коммуникационных технологий, а также в рисках, связанных с цифровизацией. На основе информации, представленной на интернет-ресурсе автономной некоммерческой организации «Цифровая экономика», а также данных министерства цифрового развития и массовых коммуникаций Российской Федерации получен вывод, что реализуемая государственная политика направлена на успешное преодоление барьеров цифровизации и реализацию накопленного потенциала цифровой экономики. Получен вывод, что перспективными направлениями цифровизации российской экономики являются расширение сфер влияния технологий, основанных на использования искусственного интеллекта, обеспечение высокой степени готовности к сетевому обществу за счет повышения компьютерной грамотности населения и подготовки цифровых специалистов, а также развитие международного сотрудничества в контексте обмена передовыми цифровыми технологиями.

The purpose of the article is to analyze the problematic aspects and promising areas of development of the digital economy in Russia. It is shown that the Russian strategy for the development of digital technologies largely corresponds to global trends, but the processes of digitalization in Russia are hampered by the presence of barriers that manifest themselves in an insufficient level of digital readiness, a shortage of competent personnel for the digital economy, legal and regulatory barriers, financial constraints, low efficiency of resource allocation in the implementation of information and communication technologies, as well as the risks associated with digitalization. Based on the information provided on the Internet resource of the autonomous non-profit organization Digital Economy, as well as data from the Ministry of Digital Development and Mass Communications of the Russian Federation, it was concluded that the implemented state policy is aimed at successfully overcoming barriers to digitalization and realizing the accumulated potential of the digital economy. It is concluded that promising areas of digitalization of the Russian economy are the expansion of the spheres of influence of technologies based on the use of artificial intelligence, ensuring a high degree of readiness for a networked society by improving computer literacy of the population and training digital specialists, as well as the development of international cooperation in the context of the exchange of advanced digital technologies.
A STUDY IN PATIENTS OF LAPAROSCOPIC MEDIAN ARCUATE LIGAMENT RELEASE
Authors: Kumar Dr.Vineeta Neeraj ,   Assistant Professor, Department of Surgery, Aarihant Homoeopathic Medical College & Research Institute, Swarnim Startup And Innovation University, Bhoyan Rathod, Near ONGC WSS, Adalaj  Kalol Highway, Gandhinagar, Gujarat-382420
Published: July 2024

AIM- To study pre-operative and post-operative management of patients of laparoscopic median arcuate ligament release METHOD- A study of 10 patients presented in surgical OPD of tertiary care hospital of radiologically proven median arcuate ligament syndrome over a period of 12 months. Patients requiring surgery were selected for the study. All the patients underwent laparoscopic Median arcuate ligament release. Post-operatively celiac artery doppler was done in all the patients. Asymptomatic patients and those undergoing open surgery for median arcuate ligament release were excluded from the study. RESULTS- Median arcuate ligament syndrome presents most commonly between 3rd and 5 th decades with male preponderance. Commonly presenting with epigastric pain or postprandial fullness. Radiological investigations are pivotal in the diagnosis and post-operative assessment. Laparoscopic median arcuate ligament release is an extremely effective surgery having substantial reduction in symptoms post operatively. CONCLUSION- Laparoscopic release of median arcuate ligament was found to be effective in substantially reducing the symptoms most commonly chronic abdominal pain ofthe patients of median arcuate ligament syndrome with short post-operative stay. Radiological investigations prove useful in diagnosis and post-operative evaluation. Early surgical intervention significantly improves the symptoms and prevents future complications including intestinal ischemia and need for emergency laparotomy surgeries. There is significant improvement in post operative blood flow based on post-operative investigations such as celiac artery doppler studies done on post operative day 1. KEYWORDS- Median arcuate ligament syndrome, Laparoscopic release of median arcuate ligament,Chronic abdominal pain
College Forums with Alumni Based on Content Filtering
Authors: Dnyeshwar Nathe Om , Rambhau More Jay , Vyankat Sarode Viraj , Sarode Prof. S.V. , Sanjay Sonawane Dnyanesh
Published: July 2024

College Forums is online discussion group. College Forums provide a common area for students, teachers, alumni to come together and discuss unlimited topics, including social activities and educational ideas Allowed Participants can create new threads under different categories and post them on timeline, the other registered users and admin allowed to comment, like or dislike that post. Admin have authority to accept or block the users, most likes post can be added in favorite list etc. Users can view their personal details and they have access to change their password. The main feature filtering abusive words added in comment part. If users make bad comment on other users post then that comment can be blocked by admin and not viewable on timeline. Users can sort post on timeline according to most likes or recently updated options. This System helps for managing all thread/post, replies and like from users with proper well-structured flow.
Jurisdicción competente respecto de estadios previos a la contratación de empleados públicos en el caso de cambio en la composición del Tribunal calificador.
Authors: Sempere Navarro Antonio V.
Published: July 2024

Cuando el contrato de trabajo se prepara a través de procedimientos dirigidos a facilitar el ingreso en el sector público surge la duda respecto de los tribunales competentes para conocer los problemas que puedan suscitarse. La jurisdicción social ha venido reclamando su propia competencia y finalmente así lo entendió la Sala de Conflictos del Tribunal Supremo. Posteriormente el legislador optó por remitir estos asuntos al orden contencioso, pero lo hizo a través de una Ley de Presupuestos Generales y el Tribunal Constitucional acabó declarando su oposición a la Ley Fundamental. La STS 815/2024 examina la competencia de litigio suscitado durante el periodo en que estaba vigente la atribución al orden contencioso, finalmente declarada inconstitucional.
When the employment contract is prepared through procedures aimed at facilitating entry into the public sector, doubts arise as to which courts are competent to hear the problems that may arise. The social jurisdiction has been claiming its own competence and finally this is how the Conflicts Chamber of the Supreme Court understood it. Subsequently, the legislator chose to refer these matters to the contentious order, but it did so through a General Budget Law and the Constitutional Court ended up declaring its opposition to the Fundamental Law. STS 815/2024 examines the jurisdiction of litigation arising during the period in which the attribution to the contentious order was in force, finally declared unconstitutional.
PENGARUH PENGALAMAN KERJA, BEBAN KERJA DAN MOTIVASI TERHADAP KINERJA GURU DI SMK NEGERI KABUPATEN BIREUEN
Authors: Amri Amri , Kamaruddin Kamaruddin
Published: July 2024

The research was conducted on State Vocational School teachers in Bireuen Regency, with the aim of knowing the effect of work experience, workload and motivation on teacher performance either partially or simultaneously. Using quantitative research methods with descriptive and verification analysis. Data obtained based on a survey with a questionnaire instrument that is measured. And statistical data analysis techniques with a path model approach (Path Models). The research results are known, (1). there is a significant correlational relationship between the exogenous variables (work experience, workload and teacher motivation). (2). Through the F-test and t-test it is proven that there is a direct effect of all exogenous variables (work experience, workload and teacher motivation) on endogenous variables (teacher performance). (3). The direct and indirect influence of work experience on teacher performance is 25.04%. (4). The direct and indirect effect of workload on teacher performance is 27.17%. (5). The direct and indirect influence of work motivation on teacher performance is 25.4%. (6) Simultaneously work experience, workload and motivation contribute to teacher performance at SMK Negeri Bireuen Regency by 58.3%. And the remaining 41.7% is the role of variables not examined, such as work culture, environment, competence and others
ANALISIS FAKTOR INTERNAL YANG MEMPENGARUHI KINERJA GURU (STUDI KASUS GURU SMP SWASTA KOTA JUANG KABUPATEN BIREUEN)
Authors: Mawardi Mawardi , Iskandar Raihan , Muttaqim Hakim
Published: July 2024

The research was conducted using a quantitative descriptive method in assessing the internal factors that affect teacher performance. The factors studied were limited to 3 (three) things, namely the level of education, teacher competence and teaching experience. Study of teachers working in private junior high schools in Juang City, Bireuen Regency. Alleged research, there is a direct influence from the causality of the three observed exogenous variables on the endogenous variable "teacher performance". There is also a correlation between exogenous variables both in substance and empirically. So the analysis uses a path model approach by building a structural framework in the form of a path diagram. The results of the study show that there are direct and indirect effects: 1) the factor of teacher education on teacher performance is 34.71%. 2) the teacher competency factor on teacher performance is 37.58%. 3) the factor of teaching experience on teacher performance is 41.8%. 4) Simultaneously the level of education, competency and teaching experience have a significant effect on the performance of private junior high school teachers in Kota Juang District, Bireuen Regency based on a coefficient of determination of 49.1%. While the remaining role of the teacher's internal variables that were not examined was 50.9%.
THE INFLUENCE OF SCHOOL ORGANIZATIONAL CLIMATE, WORK ENVIRONMENT AND JOB SATISFACTION ON TEACHER PERFORMANCE AT STATE JUNIOR HIGH SCHOOL KUTABLANG BIREUEN DISTRICT
Authors: Luthfi Muhammad , Iba Zainuddin
Published: July 2024

This study aims to determine the factors that influence teacher performance in terms of aspects of school organizational climate, work environment and teacher satisfaction factors. This research is a survey using quantitative and associative descriptive methods with the object of research being teachers who work at SMP Negeri Kutablang Bireuen District. Data analysis in the framework of hypothesis testing through statistical inference with multiple regression analysis approach. The results of the study, it was found that; (1). (1). There is a partial significant effect of School Organizational Climate (SO), Work Environment (WE) and Teacher Job Satisfaction (TS) on Teacher Performance (TP), with the regression equation TP = 16.458 + 0.470 SO + 0.518 WE + 0.339 TS. (2). Simultaneously it is proven that the variables of school organizational climate, work environment and job satisfaction have a significant effect on performance with a contribution of 40.5%. While the remaining role of variables not examined was 59.5%, including motivation, work discipline, school culture, teacher competence, and others.