bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors associated with receipt of adequate antenatal care among women in Rwanda: A secondary analysis of the 2019–20 Rwanda Demographic and Health Survey
Authors: Tengera Olive , Nyirazinyoye Laetitia , Meharry Pamela , Rutayisire Reverien , Rulisa Stephen , Haile Zelalem T.
Published: April 2023

Background

Every year, antenatal care (ANC) remains a life-saving health intervention for millions of pregnant women worldwide. Yet, many pregnant women do not receive adequate ANC, particularly in sub-Saharan Africa. The study aimed to determine the factors associated with the receipt of adequate ANC among pregnant women in Rwanda.

Methods

A cross-sectional study was conducted using the 2019–2020 Rwanda Demographic and Health Survey data. The study included women aged 15–49 years who had a live birth in the previous five years (n = 6,309). Descriptive statistics and multivariable logistic regression analyses were performed.

Results

Overall, 27.6% of participants received adequate ANC. The odds of receiving adequate ANC were higher among those in the middle household wealth index (AOR 1.24; 1.04, 1.48) and rich index (AOR 1.37; 1.16, 1.61) compared to those in the poor wealth index category. Similarly, having health insurance was positively associated with receiving adequate ANC (AOR 1.33; 1.10, 1.60). The odds of receiving adequate ANC were lower among urban dwellers compared to rural (AOR 0.74; 0.61, 0.91); for women who wanted pregnancy later (AOR 0.60; 0.52, 0.69) or never wanted pregnancy (AOR 0.67; 0.55, 0.82) compared to those who wanted pregnancy; for women who perceived distance to a health facility as a big problem (AOR 0.82; 0.70, 0.96) compared to those that did not; and for women whose ANC was provided by nurses and midwives (AOR 0.63; 0.47, 0.8), or auxiliary midwives (AOR 0.19; 0.04, 0.82) compared to those who received ANC from doctors.

Conclusion

The prevalence of women who receive adequate ANC remains low in Rwanda. Effective interventions to increase access and utilization of adequate ANC are urgently needed to further improve the country’s maternal and child health outcomes.
Netflix, Instagram, celebrity and fashion: A brave new convergent world?
Authors: Pérez Jorge
Published: April 2023

This article examines the Netflix series La casa de papel and Élite as examples of ‘media convergence’ in which content flows between several industries and creates synergies that cannot be fully explained by a television studies framework of analysis alone. By the same token, the methodological tools of traditional star studies may not provide the best lens for analysing how the actors of these series, most of them unknown until recently, have suddenly become global stars. I argue that these two series have made prominent the formation of a new paradigm of stardom, which I call ‘Insta-flix celebrity’, that compels us to develop new conceptual frameworks to theorize how multiple media – in this case Netflix, cinema, Instagram and fashion – participate in a transmedia ecology that has altered established relationships between production and consumption of media texts. Insta-flix celebrity is a phenomenon that affords audiences novel opportunities to interact with media content. With their active participation, consumers decide which stars to follow and which clothes to buy while also engaging with the series’ content and adding their own two cents – comments and social media discussion that can make or break a star, a show or a fashion brand.
The first study on clinicopathological changes in cats with feline infectious peritonitis with and without retrovirus coinfection
Authors: Moyadee Wassamon , Chiteafea Natdaroon , Tuanthap Supansa , Choowongkomon Kiattawee , Roytrakul Sittiruk , Rungsuriyawiboon Oumaporn , Boonkaewwan Chaiwat , Tansakul Natthasit , Rattanasrisomporn Amonpun , Rattanasrisomporn Jatuporn
Published: April 2023

Background and Aim: Feline infectious peritonitis (FIP) is an infectious, immune-mediated, and fatal disease in cats caused by a mutant feline coronavirus (FCoV) infection. Feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) are two common retroviruses that play a role in reducing feline immune function with opportunistic retrovirus infection being a predisposing factor for the development of FIP. This study aimed to evaluate the clinicopathological parameters of FIP in cats with and without retrovirus coinfection. Materials and Methods: In total, 62 cats presenting with pleural and/or peritoneal effusion at the Kasetsart University Veterinary Teaching Hospital, Bangkok, Thailand, were selected for the study. Effusion samples were collected and a reverse transcriptase-polymerase chain reaction (RT-PCR) assay was performed on all samples using the 3' untranslated region primer. All FCoV-positive cats were tested for retrovirus infection using a commercial kit (Witness FeLV-FIV [Zoetis]; United States). Clinical signs, hematological, and biochemical parameters of these cats were investigated and grouped. Results: Of the 62 cats with pleural and/or peritoneal effusion, FCoV was detected in 32, of which 21 were highly suspicious for FIP. The cats suspected of FIP were divided into three subgroups following viral detection. A total of 14 had only FCoV infection (Group A), four had FCoV and FeLV infection (Group B), and three had FCoV, FeLV, and FIV infection (Group C). Of the rest, 11 had definitive diagnoses, which included three being FCoV and FeLV-positive (Group D), and eight were retrovirus-negative (Group E). Mild anemia and lymphopenia were found in cats infected with these three viruses. An albumin-to-globulin ratio lower than 0.5 was found in FIP cats with only FCoV infection. Conclusion: Typically, cats with clinical effusion and FIP, with and without retrovirus coinfection, had similar hematological findings. Clinical signs, blood parameters, fluid analysis with cytological assessment, and RT-PCR assays could identify better criteria to diagnose FIP with and without retrovirus coinfection. Keywords: effusion, feline leukemia virus, feline infectious peritonitis, feline immunodeficiency virus, reverse transcriptase-polymerase chain reaction.
Detection of Trypanosoma evansi in a naturally infected cat in Indonesia using bioassay and molecular techniques
Authors: Priyowidodo Dwi , Sahara Ana , Prastowo Joko , Nurcahyo Wisnu , Firdausy Lintang Winantya
Published: April 2023

Background and Aim: The prevalence of surra in domestic cat is seldom and it is caused by Trypanosoma brucei and Trypanosoma evansi. However, molecular diagnostic approaches are required owing to similarities in their morphology. In Yogyakarta, a domestic cat was diagnosed with trypanosomiasis; however, the causative species was undetermined. Therefore, we aimed to molecularly and biologically identify the isolate. .

Materials and Methods: Approximately 1 mL of blood from an infected cat was collected into EDTA tube and separated for inoculation into donor mice, blood smear, and DNA isolation. Two donor mice was then used for increasing the number of parasite in order to infect 10 experimental mice. Parasitemia was monitored daily in each experimental mouse by preparing a wet mount and Giemsa-stained thin blood smear. The blood of experimental mice that reached the peak of parasitemia was then collected and used for DNA isolation. Each blood sample, which collected from infected cat and experimental mice, was then isolated and amplified the DNA by polymerase chain reaction using ITS-1. The parasitemia pattern and viability of the animals were observed to determine the biological characteristics of trypanosomatid, while to assess the molecular characteristics, the internal transcribed spacer (ITS)-1 amplification was used.

Results: The prepatent period of this trypanosomatid is between 2 and 4 dpi, whereas the life span of mice is approximately 4–10 dpi. Morphologically, the trypomastigote in the cat blood smear had long slender and intermediate shapes. However, only the long slender form was detected. Among the total of 410 nucleotides (NT) of ITS-1 sequences, 25 NT substitutions differed between the cat and mouse isolates. Phylogenetic analysis revealed that both samples had a close genetic relationship with T. evansi.

Conclusion: Trypanosoma evansi, a highly virulent trypanosomatid, was isolated from a cat in Yogyakarta.

Keywords: bioassay, feline, internal transcribed spacer-1 molecular detection, Trypanosoma evansi.
Estimation of conversion factors for wood stacks in landings and their influencing parameters: a comprehensive literature review for America and Europe
Authors: de Miguel-Díez Felipe , Purfürst Thomas , Acuna Mauricio , Tolosana-Esteban Eduardo , Cremer Tobias
Published: April 2023

In commercial transaction of stacked roundwood, the estimation of the stack net volume plays a key role. One generalized method to determine the net volume is using conversion factors that relate the gross and net volumes. In this literature review the developed methods to estimate the conversion factors as well as their influencing parameters were analyzed based on 153 references from America and Europe. According to the results, 48 different methods (including their variants) for estimating the conversion factors were developed. The newest methods enabled their accurate determination inexpensively, e.g., photo-optical methods or 3D simulation models. The analyzed references revealed that 30 parameters influence the conversion factors. Based on this comprehensive review, each stakeholder involved in the roundwood supply chain can know which method is used for estimating the conversion factors in the analyzed territories and which influencing parameters should be considered when purchasing roundwood in order to accurately assess the solid wood content in the stacks.
A short history of the successes and failures of the international climate change negotiations
Authors: Maslin Mark , Lang John , Harvey Fiona
Published: April 2023

The last 30 years have been a period of intense and continuous international negotiations to deal with climate change. During the same 30 years, humanity has doubled the amount of anthropogenic carbon dioxide in the atmosphere. There has, however, been progress and some notable successes in the negotiations. In 2015, at the 21st Conference of the Parties (COP21) to the United Nations Framework Convention on Climate Change (UNFCCC), 196 countries adopted the Paris Agreement stating that they would limit global temperatures to well below 2°C above pre-industrial levels and would pursue efforts to limit the temperature increase to 1.5°C above pre-industrial levels. The first review of the Paris agreement was at COP26 in Glasgow with many countries pledging to go net zero emissions by the middle of the century. But currently these pledges, if fulfilled, will only limit global average temperature to 2.4˚C to 2.8˚C. At COP27 in Egypt the core agreements from the Glasgow Climate Pact were maintained and countries finally agreed to set up a Loss and Damage facility – though details of who finances and who can claim are still be to be worked out. This article reviews the key moments in the history of international climate change negotiations and discusses what the key objectives are for future COP meetings.
A review on the genus Calophyllum (Clusiaceae): a potential medicinal tree species
Authors: Chinthu R V , Praveen Kumar B R , Raveendran M
Published: April 2023

Calophyllum is the genus of evergreen tropical flowering plants in the Clusiaceae family. They are predominantly located in Asia with some of its genus distributed in the Pacific Islands, Americas, Australasia and Africa. Plants of the genus are well known for their chemical properties with lots of secondary metabolites such as triterpenes, flavonoids, coumarins and xanthones. Compounds from Calophyllum have been reported to have cytoprotective, anti-HIV, anti-secretory, cytotoxic, antinociceptive, molluscicidal and antimicrobial properties. Some of the plants in Calophyllum are used in folk medicine to treat conditions like peptic ulcers, tumours, inflammation, infections and pain. Calophyllum genus is important with respect to their ecological as well as their medicinal properties. But in India, some species located in Western Ghats are in vulnerable stage. Even so, there is no remarkable studies carried out about this genus. So, for a sustainable environment, we should focus on the conservation, restoration and rehabilitation of the genus that makes huge differences in their population. This article reviews the genus Calophyllum of Western Ghats as a potential medicinal tree species.
Specyfika źródeł do badań politologicznych
Authors: Sielezin Jan Ryszard
Published: April 2023

Artykuł dotyczy wykorzystania źródeł w badaniach politologicznych, oceny ich przydatności, interpretacji m.in. w aspekcie krytyki wewnętrznej i zewnętrznej. Oprócz klasycznych źródeł: dokumentalnych, akt parlamentu, sądowych, administracyjnych, wojskowych, partii politycznych i ruchów społecznych wykorzystuje się inne źródła. Przykładowo źródła narracyjne: dzienniki, kroniki, pamiętniki, wspomnienia, autobiografie oraz źródła epistolarne. Dokumenty te wzajemnie się uzupełniają i należy je badać pod kątem pochodzenia, autentyczności, wiarygodności. Krytyka źródeł ma na celu m.in. wyeliminowanie dokumentów nieprzydatnych o wątpliwej wartości. W XXI w. znaczącą rolę w badaniach odgrywają źródła internetowe: blogi, vlogi, wpisy na Twitterze, Facebooku, dokumenty audiowizualne o różnym poziomie ogólności i uszczegółowienia. Ich wiarygodność i użyteczność uzależniona jest od czynności krytycznych i wykazania przydatności w badaniach.
Changing the Importance of Poland in the Security Policy of the United States in the Context of the war in Ukraine
Authors: Jureńczyk Łukasz
Published: April 2023

The aim of the paper is to analyze and evaluate the changes in the importance of Poland in the security policy of the United States after the outbreak of the war in Ukraine in 2022. The paper consists of two parts. The first one covers the importance of Poland in the US security policy after the Cold War, and the second the change of this importance after the outbreak of the full-scale war in Ukraine. The main research problem is the question of whether Poland’s importance in the US security policy has increased in connection with the Russian aggression on Ukraine? The thesis assumes that the war in Ukraine increased the importance of Poland in American security policy. This is due to three basic premises: Poland has become the main hub for American weapons supplied to Ukraine; Poland plays a key role in humanitarian support for Ukrainian refugees; and the dynamic development of the Polish army increases its importance in the defense of NATO’s eastern flank. Paradoxically, in the context of Polish-American relations, the outbreak of the war turned out to be beneficial for Poland, as earlier it was in danger of cooling down its relations with the USA in connection with the problems with adhering to the principles of the democratic state of law. Currently, this issue is overshadowed by the intensified US-Polish cooperation to help Ukraine and secure NATO’s eastern flank. The research involved interviews with scientists and analysts from scientific centers in Washington and New York.
Wpływ pandemii COVID-19 na ubóstwo energetyczne w UE
Authors: Górska Anna
Published: April 2023

Ostatnie dwa lata pandemii przyczyniły się do zwiększenia się ubóstwa energetycznego w państwach Unii Europejskiej. Ubóstwo energetyczne jest coraz powszechniejsze, z wielu powodów, takich jak rosnące ceny paliw, węgla kamiennego, opłat emisji CO2. Ubóstwo energetyczne rozumiane jest jako sytuacja, w której koszty ogrzewania przekraczają 10% dochodów. Ubóstwo energetyczne zostało zdefiniowane przez EPEE1 jako „brak środków na utrzymanie ogrzewania na odpowiednim poziomie za uczciwą cenę”.

W artykule zostaną przedstawione dane statystyczne dotyczące ubóstwa energetycznego na podstawie różnych wskaźników w latach 2018–2020 w państwach UE. Ponadto opisano aktualną politykę klimatyczno-energetyczną w UE i jej założenia oraz jej wpływ na ubóstwo energetyczne. Dodatkowo wskazane zostaną programy w państwach UE, które istotnie wpłynęły na poprawę sytuacji ubóstwa energetycznego.
Transactional Panorama: A Conceptual Framework for User Perception in Analytical Visual Interfaces
Authors: Tang Dixin , Fekete Alan , Gupta Indranil , Parameswaran Aditya G.
Published: April 2023

Many tools empower analysts and data scientists to consume analysis results in a visual interface. When the underlying data changes, these results need to be updated, but this update can take a long time---all while the user continues to explore the results. Tools can either (i) hide away results that haven't been updated, hindering exploration; (ii) make the updated results immediately available to the user (on the same screen as old results), leading to confusion and incorrect insights; or (iii) present old---and therefore stale---results to the user during the update. To help users reason about these options and others, and make appropriate trade-offs, we introduce Transactional Panorama, a formal framework that adopts transactions to jointly model the system refreshing the analysis results and the user interacting with them. We introduce three key properties that are important for user perception in this context: visibility (allowing users to continuously explore results), consistency (ensuring that results presented are from the same version of the data), and monotonicity (making sure that results don't "go back in time"). Within transactional panorama, we characterize all feasible property combinations, design new mechanisms (that we call
lenses)
for presenting analysis results to the user while preserving a given property combination, formally prove their relative orderings for various performance criteria, and discuss their use cases. We propose novel algorithms to preserve each property combination and efficiently present fresh analysis results. We implement our framework into a popular, open-source BI tool, illustrate the relative performance implications of different lenses, and demonstrate the benefits of the novel lenses and our optimizations.
CatSQL
: Towards Real World Natural Language to SQL Applications
Authors: Fu Han , Liu Chang , Wu Bin , Li Feifei , Tan Jian , Sun Jianling
Published: April 2023

Natural language to SQL (NL2SQL) techniques provide a convenient interface to access databases, especially for non-expert users, to conduct various data analytics. Existing methods often employ either a rule-base approach or a deep learning based solution. The former is hard to generalize across different domains. Though the latter generalizes well, it often results in queries with syntactic or semantic errors, thus may be even not executable. In this work, we bridge the gap between the two and design a new framework to significantly improve both accuracy and runtime. In particular, we develop a novel
CatSQL
sketch, which constructs a template with slots that initially serve as placeholders, and tightly integrates with a deep learning model to fill in these slots with meaningful contents based on the database schema. Compared with the widely used sequence-to-sequence-based approaches, our sketch-based method does not need to generate keywords which are boilerplates in the template, and can achieve better accuracy and run much faster. Compared with the existing sketch-based approaches, our
CatSQL
sketch is more general and versatile, and can leverage the values already filled in on certain slots to derive the rest ones for improved performance. In addition, we propose the
Semantics Correction
technique, which is the first that leverages database domain knowledge in a deep learning based NL2SQL solution.
Semantics Correction
is a post-processing routine, which checks the initially generated SQL queries by applying rules to identify and correct semantic errors. This technique significantly improves the NL2SQL accuracy. We conduct extensive evaluations on both single-domain and cross-domain benchmarks and demonstrate that our approach significantly outperforms the previous ones in terms of both accuracy and throughput. In particular, on the state-of-the-art NL2SQL benchmark Spider, our
CatSQL
prototype outperforms the best of the previous solutions by 4 points on accuracy, while still achieving a throughput up to 63 times higher.
Autonomic response to early head‐up tilt in patients with severe traumatic brain injury: Analysis from a randomized feasibility trial
Authors: Schultz Michala Dalsgaard , Alstrup Morten , Olsen Markus Harboe , Berg Ronan M. G. , Mehlsen Jesper , Møller Kirsten , Gunge Riberholt Christian
Published: April 2023

Patients with severe traumatic brain injury (TBI) may have autonomic dysfunction, one manifestation of which is orthostatic intolerance. This potentially impairs physical rehabilitation. However, the exact mechanisms remain elusive. In 30 patients participating in a trial of early tilt training versus standard care and 15 healthy volunteers, 5‐min electrocardiography was recorded in the supine position and during 70° head‐up tilt. Heart rate variability was analyzed by the low‐ and high‐frequency (LF and HF) power, the LF–HF ratio, the total power, the ratio of the standard deviation of normal‐to‐normal intervals (SDNN), the root mean square of successive differences (RMSSD), the detrended fluctuations, and sample entropy. In patients in the upright compared to the supine position, SDNN (p < 0.001), RMSSD (p < 0.001), and total power (p = 0.004) all decreased, while the remaining variables were unchanged; no long‐term differences in heart rate variability in the supine position were found between early tilt training and standard care. In the healthy volunteers, all measures besides SDNN and total power changed significantly between supine and upright position. In patients with severe TBI compared to healthy volunteers, several measures of heart rate variability changed differentially during mobilization from the supine to the upright position.
Towards a theory of syntactic workspaces: neighbourhoods and distances in a lexicalised grammar
Authors: Krivochen Diego Gabriel
Published: April 2023

Recent work on structure building and mapping in Minimalist syntax makes explicit reference toworkspaces; however, it is still an underexplored area. This paper is an attempt to (a) analyse the notion of ‘workspace’ as used in current Minimalist syntax and (b) provide a definition of ‘syntactic workspace’ that can help us capture interesting empirical phenomena. In doing this, we confront set-theoretic and graph-theoretic approaches to syntactic structure in terms of the operations that can affect syntactic objects and how their properties are related to the definition of workspace. We analyse the consequences of conceptualising ‘syntax’ as a set of operations that affect local regions of the workspace, defining directed graphs.
Five-Year Clinical Outcomes After XIENCE PRIME Everolimus Elution Coronary Stent System (EECSS) Implantation
Authors: Shen Rongrong , Zhang Peiyu , Liu Jing , Guo Rong , Xu Yawei
Published: April 2023

Background/aim: This study was aimed at evaluating 5-year effectiveness and safety in participants after XIENCE PRIME Everolimus Elution Coronary Stent System (EECSS) implantation.

Materials and methods: From December 2013 to May 2014, 108 patients (127 lesions) were treated with the XIENCE PRIME EECSS. The entire follow-up included annual assessments for 5 years after treatment or until one of the clinical endpoints was reached. We evaluated the 5-year clinical outcomes with Kaplan-Meier analysis and the Cox regression model.

Results: Nearly three-quarters of the participants were men (76.8%), and the average age was 65.6 ± 10.8 years. Bifurcation lesions accounted for 96.1% (122 lesions), and left main lesions accounted for 3.9% (five lesions), with a total count of 127 lesions. The cumulative rate of major adverse cardiac events was as follows: 1 year, 1.9%; 2 year, 4.0%; and 5 year, 10.0%. No definite or probable stent thrombosis was observed, and the rate of target lesion failure was only 3.3% over 5 years. The cumulative rate of major bleeding eventually increased to only 4.4%.

Conclusions: The 5-year clinical outcomes were favorable in patients treated with XIENCE PRIME EECSS, and the incidence of stent thrombosis and target lesion failure was relatively low. The incidence of major bleeding gradually increased but remained moderate.
A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes
Authors: Tabara Hiroaki , Mitani Shohei , Mochizuki Megumi , Kohara Yuji , Nagata Kyosuke
Published: April 2023

During meiosis, chromosomes with homologous partners undergo synaptonemal complex (SC)‐mediated pairing, while the remaining unpaired chromosomes are heterochromatinized through unpaired silencing. Mechanisms underlying homolog recognition during SC formation are still unclear. Here, we show that the Caenorhabditis elegans Argonaute proteins, CSR‐1 and its paralog CSR‐2, interacting with 22G‐RNAs, are required for synaptonemal complex formation with accurate homology. CSR‐1 in nuclei and meiotic cohesin, constituting the SC lateral elements, were associated with nonsimple DNA repeats, including minisatellites and transposons, and weakly associated with coding genes. CSR‐1‐associated CeRep55 minisatellites were expressing 22G‐RNAs and long noncoding (lnc) RNAs that colocalized with synaptonemal complexes on paired chromosomes and with cohesin regions of unpaired chromosomes. CeRep55 multilocus deletions reduced the efficiencies of homologous pairing and unpaired silencing, which were supported by the csr‐1 activity. Moreover, CSR‐1 and CSR‐2 were required for proper heterochromatinization of unpaired chromosomes. These findings suggest that CSR‐1 and CSR‐2 play crucial roles in homology recognition, achieving accurate SC formation between chromosome pairs and condensing unpaired chromosomes by targeting repeat‐derived lncRNAs.
Axin2 coupled excessive Wnt‐glycolysis signaling mediates social defect in autism spectrum disorders
Authors: Wang Mengmeng , Xian Panpan , Zheng Weian , Li Zhenzhen , Chen Andi , Xiao Haoxiang , Xu Chao , Wang Fei , Mao Honghui , Meng Han , Zhao Youyi , Luo Ceng , Wang Yazhou , Wu Shengxi
Published: April 2023

Social dysfunction is the core syndrome of autism spectrum disorder (ASD) and lacks effective medicine. Although numerous risk genes and relevant environmental factors have been identified, the convergent molecular mechanism underlying ASD‐associated social dysfunction remains largely elusive. Here, we report aberrant activation of canonical Wnt signaling and increased glycolysis in the anterior cingulate cortex (ACC, a key brain region of social function) of two ASD mouse models (Shank3−/− and valproic acid‐treated mice) and their corresponding human neurons. Overexpressing β‐catenin in the ACC of wild‐type mice induces both glycolysis and social deficits. Suppressing glycolysis in ASD mice partially rescued synaptic and social phenotype. Axin2, a key inhibitory molecule in Wnt signaling, interacts with the glycolytic enzyme enolase 1 (ENO1) in ASD neurons. Surprisingly, an Axin2 stabilizer, XAV939, effectively blocked Axin2/ENO1 interaction, switched glycolysis/oxidative phosphorylation balance, promoted synaptic maturation, and rescued social function. These data revealed excessive neuronal Wnt‐glycolysis signaling as an important underlying mechanism for ASD synaptic deficiency, indicating Axin2 as a potential therapeutic target for social dysfunction.
Genome-wide association studies in advanced prostate cancer: KYUCOG-1401-A study
Authors: Shiota Masaki , Tatarano Shuichi , Kamoto Toshiyuki , Matsuyama Hideyasu , Sakai Hideki , Igawa Tsukasa , Kamba Tomomi , Fujimoto Naohiro , Sekine Yuya , Kimura Hiroko , Narita Shintaro , Terada Naoki , Momozawa Yukihide , Akamatsu Shusuke , Habuchi Tomonori , Yokomizo Akira , Naito Seiji , Eto Masatoshi
Published: April 2023

Androgen-deprivation therapy (ADT) has been widely used for the treatment of advanced prostate cancer. However, prognosis and adverse events (AEs) vary among patients. This study aimed to identify genetic markers able to predict the outcome of ADT. Japanese patients treated with primary ADT for advanced prostate cancer in the KYUCOG-1401 trial were enrolled as a development set. A distinct population of advanced prostate cancer cases treated with ADT was included as a validation set. Single-nucleotide polymorphisms (SNPs) associated with radiographic progression-free survival (rPFS) at 1 year and AEs including de novo diabetes mellitus (DM), arthralgia, and de novo dyslipidemia were identified in the development set by a genome-wide association study (GWAS). The SNPs associated with rPFS in the development study were then genotyped in the validation set. GWAS followed by validation identified SNPs (rs76237622 in PRR27 and rs117573572 in MTAP) that were associated with overall survival (OS) in ADT. A genetic prognostic model using these SNPs showed excellent predictive efficacy for PFS and OS in ADT. In addition, GWAS showed that several SNPs were associated with de novo DM, arthralgia, and de novo dyslipidemia in ADT. This study identified novel multiple SNPs that correlated with outcomes in ADT. Future studies on correlations affecting the therapeutic efficacy of ADT-based combination therapies would make a valuable contribution to the development of personalized medicine.
A corpus-based study of bridge verbs in long distance dependencies in French: a specific construction
Authors: Bérard Lolita , Deulofeu Henri-José , Kahane Sylvain
Published: April 2023

This paper proposes a new analysis of long distance dependencies phenomena. The data collected through corpora indicate that the bridge verb and its dependents follow a very specific template limited to a verb with a modal interpretation and clitic pronouns. We propose an analysis based on complex predicates formation, in opposition to current analyses based on clause embedding. Therefore, there is no longer a need for long distance processes: the movement of the relative or interrogative pronoun remains local. All the constraints on this pattern will be formulated in constructional terms.
Pragmatic orientation of syntax in spontaneous speech: A corpus-based comparison between Brazilian Portuguese and Italian adverbial clauses
Authors: Bossaglia Giulia
Published: April 2023

This paper reports on the syntax of finite adverbial clauses in spoken Brazilian Portuguese (BP) and Italian (IT), based on C-ORAL-BRASIL and Italian C-ORAL-ROM corpora and founded onLanguage into Act Theory (L-AcT: Cresti 2000). The analysis of adverbial clauses here is mainly focused on the syntax/pragmatics and syntax/information structure interfaces, aiming to show significant differences in the syntax of spoken versus written language.
The pragmatics of verbal negation in Brazilian Portuguese. Hypothesis testing with corpus data
Authors: Silva Luis Filipe Lima , Mello Heliana
Published: April 2023

This paper focuses on testing a pragmatic hypothesis about verbal negation in Brazilian Portuguese (BP). The BP verbal negation system presents three forms, namely: preverbal, double, and postverbal negation. Schwenter (2005) claims that there are constraints in the use of the non-canonical forms, i.e. double and postverbal negations. According to the author, double negation can negate only inferable or directly activated propositions and postverbal negation can negate only directly activated propositions. We tested this hypothesis with data from the C-ORAL-BRASIL reference spontaneous speech corpus of BP (Raso & Mello 2012). The results show that there is a tendency for Schwenter’s hypothesis about double negation to be confirmed, but this is not the case for postverbal negation. The corpus data examined reveal a high proportion of occurrences that do not comply with the proposed hypothesis. Further research is needed to advance the understanding of constraints about the use of the non-canonical forms of negation in BP.
The role of duration and intensity factors in the characterization of modal intonation in Brazilian Portuguese spoken in the North of Brazil. Exploration of AMPER-POR data.
Authors: Cruz Regina , Rilliard Albert
Published: April 2023

The major aim of the current paper is to present an individual analysis of two physical parameters – duration (ms) and intensity (dB) – on four survey areas of Brazilian Portuguese spoken in the north of Brazil: Belém, Baião, Mocajuba and Curralinho. The selected data for this analysis stem originally from AMPER-POR database normalized by z-score.  Formerly, statistics analysis has shown that duration and intensity play a secondary role in the modal intonation characterization. These results comply with the main analysis performed on intensity in prosody studies of Portuguese by the AMPER project where it emerges not as strong parameter in modal intonation discrimination. Contrastingly, ‘duration’ has shown up as a vigorous physical parameter for the characterization of modal intonation.
Proposta de delimitação de elementos discursivos baseada na prosódia
Authors: Lucente Luciana
Published: April 2023

This article aims to show the consistent alignment between an automatic segmentation of speech in stress groups and the delimitation of discourse segments according to Grosz and Sidner model (1986). The comparison between the manual segmentation of spontaneous speech in discourse segments that carry specific purposes and the automatic segmentation of stress groups shows a persistent concentration of a specific number of stress groups in each discourse segment. Based on the previous findings (Lucente, 2012) this article compares a manual delimitation of discourse segments and an automatic delimitation of the same discourse segments according to the correlation between the number of stress groups in each discourse segment. The results point to a robust coincidence between the two segmentations.
I think we need…: Verbal expressions of opinion in conference presentations in English and in French
Authors: Hartwell Laura , Esperança-Rodier Emmanuelle , Tutin Agnès
Published: April 2023

This paper examines the frequency and functions of English and French opinion markers in 60 presentation transcripts of the EIIDA corpus in Linguistics and in Chemistry, Geochemistry, Marine, and Water Sciences. These functions, found in all four sub-corpora, include highlighting a general or strong opinion, proposing a hypothesis or negotiating with the audience, expressing doubt, or classifying information. Several important differences can be observed. First, the English verb think frequently functions as a discourse marker, more so than the French penser. In French, adverbials, the pronoun on and the conjunction que are frequent with an opinion verb, but were largely absent in English. In Linguistics, English speakers are more likely to express the subjective opinion that a result is “interesting”, whereas in the other three sub-corpora speakers are more likely to employ a modal verb, except with think, to hedge a statement. As regards to discipline, there appears to be slightly more markers of opinion in Linguistics. In the Sciences, markers of opinion are often related to an observation (on se rend compte, ‘one realizes’). Overall, opinion verbs tend here to be dialogic, serving to express doubt or to negotiate with the audience, rather than to confirm a forceful personal position.Keywords: oral academic discourse, opinion, English, French
Entre Juan de Ávila y Teresa de Jesús. Apuntes filológicos sobre su correspondencia
Authors: Varas García Julio C.
Published: April 2023

En este artículo se analizan varias versiones de la segunda carta enviada por Juan de Ávila a Teresa de Jesús en el año 1568, en la que se encuentra una aprobación del Libro de la vida de la carmelita. Con el fin de realizar una aproximación a su relación epistolar, se ofrecen algunos textos coetáneos que permiten comprender mejor su contenido y sus circunstancias. Finalmente, las variantes localizadas en las dos tradiciones textuales propuestas testifican la necesidad del análisis crítico y filológico de los textos de nuestra tradición literaria.Palabras clave: Teresa de Jesús, Libro de la Vida, Juan de Ávila, Jerónimo Gracián de la Madre de Dios, epistolario, crítica textual.Between Juan de Ávila and Teresa de Jesús. Philological notes about his correspondenceAbstract:This article discusses several versions of the second letter sent in the year 1568 by John of Ávila to Teresa de Jesús, which contains an approval of The book of the life of the Carmelite nun. In order to make an approach to his epistolary relationship, some contemporary texts that can provide meaning into its content and its circumstances are offered. Finally, the variants located in the two textual traditions proposed attest to the need for the critical and philological analysis of the texts of our literary tradition.Key words: Teresa de Jesús, Book of Life, Juan de Ávila, Jerónimo Gracián de la Madre de Dios, epistolary, textual criticism.
SPACE BIOLOGY PROJECTS IN UKRAINE: NOWADAYS TRENDS
Authors:   M. G. Kholodny Institute of Botany of the National Academy of Sciences of Ukraine, Kordyum E.L.
Published: April 2023

We present a brief overview of the results of the implementation of biological projects conducted in frame of theTarget program of the National Academy of Sciences of Ukraine for scientific space research (2018—2022) and their contribution to the current fields of world space biology: astrobiology, cellular and molecular biology, plant biology, animal biology, and gravitational biology.
DYNAMIC PROPERTIES OF NANOCOMPOSITE AND THREE-LAYER THIN-WALLED AEROSPACE ELEMENTS MANUFACTURED BY ADDITIVE TECHNOLOGIES
Authors:   A. N. Pidgorny Institute of Mechanical Engineering Problems of the National Academy of Sciences of Ukraine, Avramov K.V. , Uspensky B.V. ,   A. N. Pidgorny Institute of Mechanical Engineering Problems of the National Academy of Sciences of Ukraine, Derevyanko I. I. ,   Yangel Yuzhnoye State Design Office, Degtyaryov M.O ,   Yangel Yuzhnoye State Design Office, Polishchuk O.F. ,   A. N. Pidgorny Institute of Mechanical Engineering Problems of the National Academy of Sciences of Ukraine, Chernobryvko M.V. ,   A. N. Pidgorny Institute of Mechanical Engineering Problems of the National Academy of Sciences of Ukraine
Published: April 2023

Nanocomposite and sandwich plates with a honeycomb core are characterized by a high strength-to-mass ratio. Thus, such a solution is very promising for the aerospace and aircraft industry. This paper represents a mathematical model for a nanocomposite functionally gradient cylindrical shell interacting with a supersonic gas flow. To obtain such a model, the predetermined form method is used. An ordinary nonlinear differential equations system is obtained to describe the self-sustained vibrations of the shell. The structure model is developed using nonlinear strain-displacement relationships to analyze self-sustained vibrations. A model describing self-sustained vibrations of a sandwich conical shell interacting with a supersonic gas flow is obtained. The core layer of the shell is an FDM-manufactured honeycomb. The stress state of the structure is analyzed using the highorder shear deformations theory. Each layer’s stress state is described by five coordinates which are the three displacements of the midsurface and two angles of rotation of the normal to the midsurface. At the layers’ junctions, the border conditions of displacements’ continuity are used. To analyze self-sustained vibrations, the nonlinear strain-displacement relationships are utilized. Using the normal modes technique allows us to obtain a nonlinear autonomous dynamic system. Results of numerical simulations of self-sustained vibrations are provided. They are obtained by solving a nonlinear boundary value problem for the ordinary differential equations system using shooting and continuation techniques. Experimental investigation of sandwich plates’ fatigue with honeycomb core is considered. A method of fatigue testing of sandwich plates is described. The testing results are presented using S-N diagrams.
PECULIARITIES AND ADVANTAGES OF STUDYING THE SURFACES OF SPACE TECHNIQUE MATERIALS BY ATOMIC FORCE MICROSCOPY
Authors:   Main Astronomical Observatory of the National Academy of Sciences of Ukraine, Shevchenko O.I. , Itsenko A.I. ,   I. M. Frantsevich Institute for Materials Science of the National Academy of Sciences of Ukraine, Bondarenko M.O. ,   Cherkasy State Technological University
Published: April 2023

The article presents the advantages of the atomic force microscopy (AFM) method as one of the most versatile and promising methods for studying the surfaces of space engineering materials. A comparison of the results of the study of such materials using the example of aluminum nitride (AlN) by the methods of scanning electron microscopy (SEM) and AFM was carried out. As a result of the comparison, it was established that, despite the higher resolution of the SEM method, its main disadvantages are the impossibility of vertical scanning of surfaces and the lack of an opportunity to study their physical and mechanical properties. The main features of the process of studying the topography of surfaces using the AFM method have been established. They are the possibility of high-precision positioning of the measuring instrument (with the accuracy of determining a given area — up to 40 nm), elimination of distortion of the obtained image of the studied area, and automatic correction of the research speed. The arithmetic mean values of the micro-roughnesses of the aluminum nitride surfaces obtained by the AFM method were determined both for samples that were not exposed to extreme environmental conditions (Ra = 147 nm; Rq = 163 nm) and samples that were exposed to extreme environmental conditions for a long time (120...140 hours), which simulates space conditions (temperature 550 °С, pressure 6.8...7.2 μbar) (Ra = 381 nm; Rq = 422 nm). The maximum porosity in the surface layer (up to 1.5 μm) of aluminum nitride samples was also determined in the range of 3...5.2%.
The Fruit Flies (Diptera, Tephritidae) in Bhutan: New Faunistic Records and Compendium of Fauna
Authors: Korneyev S. V. , Hauser M. , Borkent C. , Maples B. K. , Roubtsova T. V. , Zangpo T. , Dorji S. , Chophel S. , Dorji N. , Tsomo Tsomo , Dendup U. , Dawa K. , Dorji L. , Mani Dhimal C. , Kinley R. , Dorji U. , Dema Y. , Korneyev V. A. , Gaimari S. D.
Published: April 2023

Based on a field survey from 2017, twenty-three species are reported from Bhutan for the first time: Acroceratitis ceratitina, A. hardyi, Anomoia approximata, Bactrocera connecta, B. latifrons, B. nigrifacia, B. syzygii, Campiglossa sororcula, Cecidochares connexa, Dacus jacobi, Gastrozona fasciventris, Hoplandromyia antelopa, Lenitovena ultima, Ptilona confinis, Rioxoptilona dunlopi, R. formosana, R. vaga, Spathulina acroleuca, Themara yunnana, Trypeta indica, Zeugodacus apiciflavus, Z. diversus, and Z. fereuncinatus. Four species of the genera Cornutrypeta, Hemilea, Morinowotome, and Vidalia are also recorded for the first time, but the precise determination to species needs additional study and material. As the result, 71 species is listed from Bhutan by far. Their taxonomic position and key characters are discussed. Illustrations for most of the newly recorded species are given.
New Records of Hoverflies (Diptera, Syrphidae) from Ukraine. VI
Authors: Prokhorov A. V. , Popov G. V. , Shparyk V. Yu. , Vasilyeva Yu. S.
Published: April 2023

Nine species of hoverflies of the subfamilies Eristalinae, Pipizinae and Syrphinae are recorded from Ukraine for the first time: Cheilosia himantopus (Panzer, 1798), Orthonevra incisa (Loew, 1843), Neocnemodon verrucula (Collin, 1931), Pipiza luteibarba Vujić, Radenković & Polić, 2008, Trichopsomyia joratensis (Goeldlin de Tiefenau, 1997), T. lucida (Meigen, 1822), Dasysyrphus neovenustus Soszyński, Mielczarek & Tofilski, 2013, Platycheirus europaeus Goeldlin de Tiefenau, Maibach & Speight, 1990, P. sticticus (Meigen, 1822). Distributions of these species are summarized and species diagnoses are provided.
The Red Data Book Waterbirds in the Coastal Wetlands of the Azov-Black Sea Region of Ukraine — the Results of the August Counts 2018 and 2021
Authors: Chernichko J. I. , Kostiushyn V. A. , Vinokurova S. V.
Published: April 2023

The article analyses data from the August Counts of 2018 and 2021, which covered the 40 most important wetlands on the Azov-Black Sea coast of Ukraine. Of the 106 wetland bird species recorded during the censuses, 35 species are listed in the Red Data Book of Ukraine. The number of them was about 50 thousand individuals or 7.6 % of the total number of counted birds: in 2018 — 24.1 thousand individuals and in 2021 — 25.8 thousand individuals. Detailed information on the number of bird species and the list of the most important sites for each species can be found in the publication. The comparison of the current data with the previous survey period 2004‒2015 (Chernichko et al., 2018) showed that the abundance of 17 waterbird species decreased, and 7 species increased their abundance. It is assumed that these changes are caused by the aridification of the climate, leading to the drying out of the shallow parts of the region's wetlands in the second half of the summer.
Characteristic and risk factors of retinopathy of prematurity in Sanglah Hospital Denpasar: 3-years retrospective study
Authors: Sutyawan I Wayan Eka , Lie Maria Vinsensia , Indraputri Intan Ade , Surasmiati Made Ayu , Andayani Ari , Suryati Ni Made Ari
Published: April 2023

Introduction: Retinopathy of prematurity (ROP) is one of the important causes of blindness in children. ROP is characterized by abnormal retinal neovascularization of premature infants.
Purpose: This study aimed to estimate the prevalence of ROP in preterm infants at Sanglah Hospital Bali from 2015-2017 and identify the risk factors predisposing them to ROP.
Methods: This was a retrospective study, observational analysis on premature infants diagnosed as ROP at Sanglah Hospital Bali from January 2015 to December 2017, with a gestational age of 30 weeks or less at birth and a birth weight of 1500 grams or less. Infants whose gestational age was >30 weeks or whose birth weight was >1500 grams were also included. The ophthalmological examinations were initiated between the fourth and sixth weeks of chronological age or 34 weeks of corrected age, whichever was earlier, and were repeated weekly or biweekly as per Indonesian guidelines for ROP screening, until full vascularization of the retina reached zone 3.
Results: Out of 31 infants diagnosed as ROP, 3 (9.7%) cases developed ROP in one eye, and 28 (90,3%) cases in both eyes. They were classified as 23 (74.2%) cases stage 1, and 8 (25,8%) cases stage 2. None of the studied infants presented ROP at stage 3, 4, or 5. The risk for ROP was not significantly associated with birth weight (OR 0.375; 95% CI 0.030 – 4.635), gestational age (OR 0.897; 95% CI 0.792 – 1.015), sepsis (OR 1.111; 95% CI 0.089 – 13.835), blood transfusion (OR 1.111; 95% CI 0.089 – 13.835), and HMD (OR 1.118; 95% CI 0.977 – 1.443).
Conclusions: The data of this study showed that low gestational age, low birth weight, sepsis, oxygen therapy, and blood transfusion may be contribute to the development of ROP, but not significant statistically. Clinicians should be aware of the presence of the additional risk factors when monitoring preterm infants,especially when giving supplemental oxygen therapy.