bluuebunny/crossref_metadata_2025 huggingface dataset:
DETECTION OF ALFACORONAVIRUSES, BETACORONAVIRUSES AND ASTROVIRUSES IN BAT FECAL SAMPLES FROM MOSCOW REGION
Authors:   Federal Budget Institute of Science «Central Research Institute of Epidemiology», Moscow, Russia, Korneenko E.V. , Samoilov А.E. ,   Federal Budget Institute of Science «Central Research Institute of Epidemiology», Moscow, Russia; Pasteur Research Institute of Epidemiology and Microbiology, Saint Peterburg, Russia, Artyushin I.V. ,   M.V. Lomonosov Moscow State University, Moscow, Russia, Safonova M.V. ,   Anti-Plague Center of the Federal Service for the Protection of Consumer Rights and Human Well-Being, Russia, Dedkov V.G. ,   Pasteur Research Institute of Epidemiology and Microbiology, Saint Peterburg, Russia, Khafizov K.F. ,   Moscow Institute of Physics and Technology (National Research University), Moscow, Russia, Deviatkin A.A. ,   First Moscow State Medical University (Sechenov University), Moscow, Russia, Kaptelova V.V. ,   Federal Budget Institute of Science «Central Research Institute of Epidemiology», Moscow, Russia, Pimkina E.V. ,   Federal Budget Institute of Science «Central Research Institute of Epidemiology», Moscow, Russia, Speranskaya A.S. ,   Federal Budget Institute of Science «Central Research Institute of Epidemiology», Moscow, Russia; M.V. Lomonosov Moscow State University, Moscow, Russia
Published: November 2020

In our study we analyzed viral RNA in bat fecal samples from Moscow region (Zvenigorod district) collected in 2015. To detect various virus families and genera in bat fecal samples we used PCR amplification of viral genome fragments, followed by high-throughput sequencing. Blastn search of unassembled reads revealed the presence of viruses from families Astroviridae, Coronaviridae and Herpesviridae. Assembly using SPAdes 3.14 yields contigs of length 460–530 b.p. which correspond to genome fragments of Coronaviridae and Astroviridae. The taxonomy of coronaviruses has been determined to the genus level. We also showed that one bat can be a reservoir of several virus genuses. Thus, the bats in the Moscow region were confirmed as reservoir hosts for potentially zoonotic viruses.
THE IMPORTANCE OF ANTI-HCV SCREENING IN PATIENTS OF LARGE MULTIFIELD HOSPITALS
Authors:   Moscow Regional Research Clinical Institute named after M.F. Vladimirsky, Kudrjavtseva E.N. , Korabelnikova M.I. ,   Moscow Regional Research Clinical Institute named after M.F. Vladimirsky, Semenenko T.A. ,   N.F. Gamaleya NRCEM, Panasyuk Ya.V. ,   Federal Budget Institute of Science «Central Research Institute of Epidemiology», Kuzin S.N. ,   Federal Budget Institute of Science «Central Research Institute of Epidemiology»
Published: November 2020

In the studied cohort, HCV subtypes 1b and 3a prevailed — 47,7% and 38,9%, respectively HCV genotype 2 was detected in 7,2% of cases and HCV subtype 1a — in 5,8% of cases. HCV genotype was not determined in 0,4% of patients. Difference between a frequency of detection of subtypes 1b and 3a of HCV in men and women were recorded. Subtype 3a HCV was determined in men in 44,8% of cases, and in women — in 31,7% of cases (p < 0.01). HCV subtype 1b in women was determined with a higher frequency (55,0%, р < 0, 01), than in men (41,8%)
necessidade da revolução democrática para uma nova ordem social
Authors: Alves de Lima Filho Paulo
Published: November 2020

Somente uma revolução democrática permitirá a conquista da plena soberania econômica e política da nação. Por força da particularidade capitalista desta, ela será necessariamente anticapitalista, abrindo-se para um processo de superação do capital, como transição comunista.
Entrevista com Carmen Junqueira
Authors: Lopes Faggiano Daniel
Published: November 2020

A primeira entrevista desta edição número 3 da Revista Fim do Mundo é com a antropóloga e professora emérita da PUC-SP, Dra. Carmen Junqueira. Seu vasto trabalho de campo junto aos povos indígenas e seu posicionamento em defesa das comunidades tradicionais a destacam como referência nas ciências sociais brasileira. A entrevista foi realizada pelo indigenista e pesquisador do IBEC, Daniel Lopes Faggiano.
Brasil pandêmico visitado na distopia 1984 de George Owell
Authors: Chiariello Caio Luis
Published: November 2020

O presente artigo apresenta uma contextualização do cenário brasileiro de 2020, em meio a mais grave pandemia dos últimos 100 anos, à luz da obra distópica 1984 de George Orwell, ficção sobre um futuro totalitário e opressor, publicada em 1949. Buscou-se elencar elementos da obra que apontam similaridades com o caso brasileiro, como a evocação de uma narrativa de ódio a opositores, gestão executiva destoando de sua missão institucional, uso deliberado de inverdades colocadas a público. As peças de acusação Dois Minutos de Ódio; Os Anti-ministérios e o Falseamento da verdade, extraídas de 1984, buscam expor tais similaridades.
Allah Trinitaris Dalam Refleksi John Zizioulas
Authors: Fu Lan Yap
Published: November 2020

Abstrak: John Zizioulas merefleksikan kembali doktrin Allah Trinitaris dan mencoba mencari cara-cara baru menolong umat beriman zaman ini menemukan makna ajaran iman ini. Merujuk teologi para Bapa Gereja Kapadokia, Zizioulas mengajukan gambar Allah Trinitaris sebagai Pribadi yang berkomunitas. Pribadi memiliki tiga karakteristik: primer dan absolut, ekstasis dan hipostasis, unik dan tak tergantikan. Pribadi selalu bergerak ke luar dirinya, ke arah pribadi yang lain, maka ia menerima keberbedaan. Kehidupan dan identitas otentik pribadi ditemukan hanya di dalam komunitas yang dibangunnya bersama pribadi-pribadi yang lain. Gerak Pribadi Allah adalah eros, cinta yang merangkul pribadi-pribadi yang lain beserta keberbedaan mereka, yakni manusia dan segenap ciptaan. Berkomunitas dengan Allah dan segenap ciptaan, manusia melampaui substansi manusiawi dan kondisi naturalnya. Manusia tidak lagi menjadi milik kematian melainkan kehidupan kekal. Gereja adalah image Allah Trinitaris karena ia adalah komunitas pribadi-pribadi yang mengalami kelahiran baru oleh Roh Kudus di dalam peristiwa Kristus. Sebagai image Allah Trinitaris, cara Gereja hadir di dunia ialah dengan menjadi komunitas katolik dan ekaristis. Untuk menjadi komunitas katolik-ekaristis, pembaruan cara hidup, struktur hirarkis, dan pelayanan Gereja adalah sebuah kebutuhan.

Kata-kata Kunci: pribadi, substansi, ekstasis-hipostasis, keberbedaan, identitas otentik, komunitas ekaristis, imago Dei/Trinitatis, eros.

Abstract: John Zizioulas did his reflection on the doctrine of the Trinity in term to seek new ways that help the faithful to grasp the meaning of this teaching. Referring to the theology of Cappadocian Fathers, Zizioulas provides a picture of the Trinity as Persons within communion. A person has three primary characteristics: primary and absolute, ecstatic and hypostatic, unique and irreplaceable. A person always moves towards others, thus she/he embraces otherness. The very life and authentic identity of a person can be found only in communion with others. The Person of God moves as eros, God’s love which embraces the others and otherness, i.e. human beings and the rest of creation. Being in communion with God and all creations, human being overcomes the human substance and its nature. Human being no longer belongs to death but to eternal life. The church is an image of the Trinity for it is a communion of the new persons that were delivered by the Holy Spirit within the Christ event. As the image of the Trinity, the Church’s way of being in this world is by becoming a catholic and eucharistic community. To be such a community, the renewal of the Church’s way of life, hierarchical structure, and ministries is a necessity.

Kata-kata Kunci: Person, substance, ecstatic-hypostatic, otherness, authentic identity, eucharistic community, image of God/image of the Trinity, eros.
TEKNOLOGI FITOREMEDIASI UNTUK PENANGANAN PENCEMARAN LOGAM BERAT DI LAHAN PERTANIAN DI KECAMATAN KEBAKKRAMAT KABUPATEN KARANGANYAR
Authors: Rosariastuti MMA. Retno , Supriyadi Supriyadi , Widiastuti Wiwin
Published: November 2020

Research aim of heavy metal pollution handling in agricultural land use fitoremediation technologyis to know the effectivity of hemp and mendong plant used and it’s combination with rhizobacterial isolates Agrobacterium sp I3 or organic materials in order to decrease  the levels of heavy metal contamination in the soil such as cromium (Cr), cadmium  (Cd) and plumbum (Pb).The research was conducted in Waru Village Kebakkramat Sub-District Karanganyar Regency in 2016. The location is a subdistrict in Karanganuyar Regency whose area has many industries, mainly textile industry.Industrial wastewater in this region is widely used to irrigate rice fields by farmers, so the paddy fields have been polluted by Cr, Cd and Pb.Therefore, it is necessary to decrease the contamination of heavy metals in paddy fields with the selection of environmentally friendly remediation technology, low cost, easy and sustainable.The method of remediation in that category is bioremediation using a plant called phytoremediation.For that required plants that have rapid growth and high metal absorption capability.The character are owned by hemp and mendong plants.Based on previous research obtained Agrobacterium sp I3 rhizobacteria which proved able to increase the uptake of Cromium by hemp plant.The research result showed that hemp and mendong plants can absorb metal either Pb, Cd, or Cr.Based on the amount of metal absorption value in root and plant canopy, hemp plant and mendong shows its ability as hyper akumulator plant (the amount of uptake ≥ 100 ppm).The highest decrease of soil Pb content was 39,406% without treatment of basic fertilizer, with rhizobacterial inoculation Agrobacterium sp I3 and hemp plant.The highest decrease of soil Cd content was 56,604% with treatment with basic fertilizer, with inoculation of rhizobacteria Agrobacterium sp I3 and mendong plant.The highest decrease of Cr content of soil was 42,27% with treatment of basic fertilizer, without inoculation of Agrobacterium sp sp I3 and without hemp and mendong plants.
OPTIMALISASI LAYANAN PASIEN UMUM DAN KUSTA DI RSUD KELET
Authors: Risandewi Tri
Published: November 2020

Data Kementerian Kesehatan RI per April 2019 menunjukkan bahwa Provinsi Jawa Tengah merupakan salahsatu provinsi yang memiliki jumlah kasus baru kusta sebanyak 1.445 atau 8,49 persen dari total jumlah kasus di Indonesia. RSUD Kelet sebagai salahsatu RS rujukan pasien kusta perlu meningkatkan kualitas layanan terhadap pasien kusta walaupun sudah beralih menjadi RSUD. Oleh sebab itu, perlu dilakukan penelitian mengenai konsekuensi penyebaran penyakit kusta terhadap pelayanan pasien kusta di Provinsi Jawa Tengah dan bagaimana kualitas pelayanan kepada pasien kusta dan umum, serta bagaimana strategi RSUD Kelet dalam meningkatkan kualitas pelayanan pasien. Metode penelitian yang digunakan adalah kualitatif deskriptif, dengan metode pengumpulan data melalui telaah dokumen, observasi, FGD dan wawancara mendalam. Lokasi penelitian ini di RSUD Kelet Kabupaten Jepara dan beberapa kabupaten/kota yang terdeteksi kasus kusta (Kabupaten Blora, Brebes, Kota Pekalongan, dll). Hasil penelitian menunjukkan dampak penyebaran penyakit kusta terhadap pelayanan pasien kusta di Jawa Tengah saat ini menyebabkan layanan penderita kusta di faskes belum optimal karena sistem rujukan yang berjenjang, akses ke RS rujukan terlalu jauh, tata laksana dan perawatan untuk pasien kusta di faskes masih kurang memadai dan stigma negatif dari masyarakat. Perubahan status RS khusus kusta menjadi RSUD Kelet terhadap pelayanan kusta tidak memberikan dampak negatif namun malah mampu menjadi supporting system bagi pelayanan penderita kusta serta mampu memberikan dampak positif peningkatan pendapatan RSUD Kelet. Strategi pengembangan ke depan yaitu ingin mengembangkan RSUD Kelet sebagai center of excellent, RS pusat penelitian kanker dan RS kusta berbasis penelitian serta mengintegrasikan antara kesehatan, lingkungan dan wisata dengan pengembangan kawasan sekitar RSUD Kelet Jepara.
A narrative review of ambulatory care education in Canadian internal medicine
Authors: Spiegle Gillian , Yin Penny , Wright Sarah , Ng Stella , O'Brien Tara , Friesen Farah , Friesen Michael , Shah Rupal
Published: November 2020

Background: The Canadian healthcare system faces increasing patient volumes and complexity amidst funding constraints. Ambulatory care offers a potential solution to some of these challenges. Despite growing emphasis on the provision of ambulatory care, there has been a relative paucity of ambulatory care training curricula within Canadian internal medicine residency programs. We conducted a narrative review to understand the current state of knowledge on postgraduate ambulatory care education (ACE), in order to frame a research agenda for Canadian Internal Medicine ACE.

Methods: We searched OVID Medline, Embase, and PsycINFO for articles that included the concepts of ambulatory care and medical or health professions education from 2005-2015. After sorting for inclusion/exclusion, we analyzed 30 articles, looking for dominant claims about ACE in Internal Medicine literature.

Results: We found three claims. First, ACE is considered to be a necessary component of medical training because of its distinction from inpatient learning environments. Second, current models of ambulatory care clinics do not meet residency education needs. Third, ACE presents opportunities to develop non-medical expert roles. 

Conclusions: The findings of our narrative review highlight a need for additional research regarding ACE in Canada to inform optimal ambulatory internal medicine training structures and alignment of educational and societal needs.
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LEDIPASVIR AND SOFOSBUVIR IN BULK DRUG BY USING RP-HPLC
Authors: RowthulaPrasanna Surya Bhavani Rowthula Prasanna Surya Bhavani , M.Sandhya Maduri M.Sandhya Maduri
Published: November 2020

A new, simple, precise, accurate, and reproducible RP-HPLC for stability-indicating method development and validation of Ledipasvir and Sofosbuvir in bulk form. Separation ofLedipasvir and Sofosbuvir was successfully achieved Dona Zorbax C8, 250 X4.6mm, 5µm or equivalent in an isocratic mode utilizing 0.1% OPA: Methanol (45:55) at a flow rate of 1.0mL/min and the eluate was monitored at 238nm, with a retention time of 3.303 and 7.303minutes for Ledipasvir and Sofosbuvir respectively. The method was validated and their response was found to be linear in the drug concentration range of 45µg/ml to135 µg/ml for Ledipasvirand 200µg/ml to 600 µg/ml for and Sofosbuvir. The values of the correlation coefficient were found to 0.999 for Ledipasvirand 1 for Sofosbuvir respectively. The LOQ for Ledipasvirwere found to be  0.695 respectively. The LOQ for Sofosbuvir was found to be 2.2063 respectively. This method was found to be a good percentage recovery for Ledipasvir and Sofosbuvirwere found to be 100 and 100 respectively indicates that the proposed method is highly accurate. The specificity of the method shows a good correlation between retention times of standard with the sample so, the method specifically determines the analyte in the sample without interference from the excipients of tablet dosage forms. The method was extensively validated according to ICH guidelines for Linearity, Accuracy, Precession, Specificity, and Robustness.
Structure, typology, present state and perspectives of second housing in Czechia
Authors: Fialová Dana , Vágner Jiří
Published: November 2020

The paper begins with giving basic information on second housing - individual short-term recreation of population in Czechia - aimed at its structure and distribution. A short characteristic of the history of the research into and of the basic development of structure of the second homes is given. This structure was roughly completed prior to the 1990s. The empirical part deals with field and inquiry research into regional differentiation of this phenomenon in model regions of the whole Czechia and results into a tentative typology of fields of second housing and into more general conclusions on the main trends and perspectives.
Geomorphological aspects of monitoring movements of rock blocks in pseudocarst localities Ostaš, Hejda and Kočičí skály
Authors: Stejskal Vladimír
Published: November 2020

Since 1989 slope movements and movements of tectonic origin have been monitored in three pseudocarst localities in Polická vrchovina. Monitoring has allowed to detect more or less distinct manifestations of slope movement activity in the majority of observing points. A detailed geomorphological analysis has shown time variability of the mechanism of slope movements. Presence of movements of tectonic origin hasn't been proved.
Adossement des épreuves d’expression orale et écrite du Test de connaissance du français (TCF) sur les Niveaux de compétences linguistiques canadiens (NCLC) et correspondance avec les niveaux du Cadre européen commun de référence pour les langues (CECRL)
Authors: Folny Vincent
Published: November 2020

En 2015, le CIEP a mené une étude afin de pouvoir adosser les productions écrites et orales du Test de connaissance de français (TCF) aux NCLC et d’établir une correspondance avec les niveaux du CECRL. In fine, Il s’agissait d’assurer aux candidats à l’immigration au Canada une bonne interprétation de leur niveau de compétence et de pouvoir expliquer les procédures mise en place pour l’interprétation des scores. Pour assurer l’adossement des épreuves d’expression écrites et orales du TCF aux niveaux NCLC, plusieurs procédures et études ont été mises en place : utilisation des niveaux CECR attribués à une sélection de productions au cours des corrections du TCF, séminaire organisé avec des panélistes pour attribuer des niveaux NCLC à ces mêmes productions, analyses psychométriques pour le calibrage de la sélection de productions, évaluation du lien entre les niveaux attribués avec les deux échelles (NCLC et CECR) afin de vérifier la convergence des résultats, analyses qualitatives des descripteurs NCLC et CECR et mise en correspondance.
Editorial
Authors: Saif Shahrzad , ElAtia Samira
Published: November 2020

Editorial
Synthesis and Characterization of Water Dispersible Iron Oxide (�a-Fe2O3) Nanoparticles for Biomedical Applications
Authors: Malaeru Teodora , Patroi Delia , Enescu Elena , Georgescu Gabriela , Manta Eugen , Patroi Eros Alexandru , Marinescu Virgil , Morari Cristian , Lungu Magdalena Valentina
Published: November 2020

In this study, L-lysine coated �a-Fe2O3 nanoparticles were synthesized by a chemical approach in two steps. In the first step �a-Fe2O3 nanoparticles were synthesized by a polyol-reduction method. XRD analysis confirmed the presence of cubic maghemite phase with an average crystallite size of 9.2 nm. SEM analysis showed that the prepared �a-Fe2O3 nanoparticles have a spherical structural morphology with the tendency of agglomeration and with size in the range 8.36- 10.69 nm. The �a-Fe2O3 nanoparticles were coated with L-lysine in the second stage in an aqueous dispersion with ultrasonication followed by a gentle heating at 40��C. FT-IR spectroscopy confirmed the presence of L-lysine on the nanoparticles surface and the Zeta potential also supported the coating of nanoparticles with a hydrophilic layer of amino acid (L-lysine) and a good stability in aqueous medium. Hysteresis loop shows a ferromagnetic behavior at room temperature for both samples.
The Impact of Land Use Change on Perform (Soil-Water) System in Middle Part of Mesopotamian Plain
Authors: Bayaty Majd Al , Mousawi Eman Al
Published: November 2020

In spite of hydrology and geology disciplines` are relatively well known in Iraqi management strategy, unlike soil and its distribution system. Thus, describing strong indicator for evaluating water pathways, minerals, and materials in different soils is necessary to reduce the associated risks. However, the aim of this research is identified the change in soil behavior by observation, and interpretation the facts for effective indication mode. This mode is evaluated some features and properties in (soil- water) horizons from a focus on land use change in (e.g built up and rural) areas compared with riparian sites in middle region of Iraq. The evaluation is included field sampling by using `Drill auger` instrument and laboratory tests for analysis. The results areinterpreted as onset of soil impairment indices under changing in human activities, agricultural practices, climate change and effect of water movement. The elements are considerably bound with silt and clay particles which ultimately minimize leaching ability to lower layers in each horizon. The free access of water and air allows rapid oxidation of elements and caused materials corrosion and the output of leaches which can contaminate ground water and surface water. Besides, some elements are negatively correlated with concentrations of calcium carbonate. The content of sulfur compound in assorted land uses is uneven and increased with increase water content or agitating time. Also, the sulfur oxidation even if small proportion in fill material lead to the output of polluted drainage water and attack construction material when structural backfill and for bulk fill. Thus, its significant to consider these features for ameliorative engineering behavior.
MHD FLOW OF AN EYRING-POWELL FLUID WITH THE EFFECT OF THERMAL RADIATION, JOULE HEATING AND VISCOUS DISSIPATION
Authors: Babu K.R. , Narender G. , Govardhan K.
Published: November 2020

A two-dimensional stream of an magnetohydrodynamics (MHD) Eyring-Powell fluid on a stretching surface in the presence of thermal radiation, viscous dissipation and the Joule heating is analyzed. The flow model in the form of the Partial Differential Equations (PDEs) is transformed into a system of non-linear and coupled Ordinary Differential Equations (ODEs) by implementing appropriate similarity transformations. The resulting ordinary differential equations are solved numerically by the shooting technique with Adams-Moulton Method of fourth order. The numerical solution obtained for the velocity and temperature profiles has been presented through graphs for different choice of the physical parameters. The magnetic field is found to have a direct relation with the temperature profile and an inverse with the velocity profile. Increasing the thermal radiation, the temperature tends to rise.
The Dyson Multiplying Effect
Authors: Derval Diana
Published: November 2020

Talking about visionary entrepreneurs, Dyson revolutionized the quite boring home appliances category with a bag-less vacuum cleaner, a fan without blades, and more recently a 23.75 carat golden hairdryer. The group based in Malmesbury generated over 4 billion euros in sales last year, hitting a new high. Asia was driving 73% of this phenomenal 40% growth (1). But how did Dyson achieve this tour de force? What can other brands targeting the Asian or the luxury market learn from it? Dyson managed to dominate its markets with more expensive products, by targeting the right personas, making sure products are must-haves, demonstrating their benefits, learning from failure, and keeping a sharp vision.
Senėjimo sąlygoti astmos patogenezės pokyčiai
Authors: Kalinauskaitė-Žukauskė Virginija , Malakauskas Kęstutis
Published: November 2020

Senėjimas - natūralus procesas, prasidedantis vos gimus, kuris apima visą organizmą, įskaitant ir kvėpavimo takus. Amžiniai kvėpavimo sistemos anatominiai, fiziologiniai ir imuniniai pokyčiai gali turėti įtakos plaučių funkcijai bei įvairių kvėpavimo sistemos ligų eigai. Astma - viena labiausiai paplitusių lėtinių kvėpavimo takų ligų visame pasaulyje, todėl organizmo senėjimo poveikis šios ligos patogenezei itin aktualus. Pasaulinės sveikatos organizacijos (PSO) duomenimis, sparčiai auga astmos paplitimas vyresnio amžiaus žmonių grupėje, būdinga sunkensė eiga, mažesnis standartinių gydymo metodų veiksmingumas, blogesnės baigtys. Pastebėti astmos (ypač sunkios) patogenezės ir natūraliai sveikuose plaučiuose žmogui senstant vykstančių procesų panašumai. Norint kuo geriau suprasti astmos patogenezės mechanizmus, pastarąjį dešimtmetį didėjo domėjimasis pagrindinių ligos patogenezėje dalyvaujančių uždegimo ląstelių sąveika su struktūriniais apatinių kvėpavimo takų elementais. Manoma, kad etapinis kvėpavimo takų remodeliacijos procesų blokavimas galėtų pristabdyti struktūrinių pokyčių progresavimą ir sąlygoti geresnį gydymo efektą.
Laisvos DNR reikšmė diagnozuojant plaučių vėžį
Authors: Serapinas Danielius , Medvedeva Arina , Čepaitė Justė , Mickevičiūtė Giedrė
Published: November 2020

Tradiciškai vėžio diagnozė nustatoma taikant histologinius ir radiologinius tyrimo metodus, tačiau tobulėjant molekuliniams tyrimo metodams, atrandama vis daugiau biožymenų, kurie padeda vėžį klasifikuoti į molekulinius tipus. Remiantis šiais molekuliniais tipais, galima skirti navikui specifinį gydymą ir sulaukti geresnių rezultatų. Daugumai biožymenų aptikti ir nustatyti reikalingos invazinės procedūros: chirurginė naviko ekscizija, biopsijos paėmimas ar plonos adatos aspiracija. Tuo tarpu aptikti ir ištirti laisvą DNR (ang. cell free DNA, cfDNA) tereikia minimaliai invazinės procedūros, vadinamosios skystos biopsiijos. cfDNR - jautrus, specifiškas biožymuo, suteikiantis galimybę anksti nustatyti naviko diagnozę, stebėti naviko masę, liekamąją ligą bei atsparumą gydymui. cfDNR atspindi visą naviko genomą bei navikui būdingą heterogeniškumą, o tai leidžia skirti pacientui individualizuotą gydymą.
Pacientų, serganių pirminiu imunodeficitu, priežiūra
Authors: Tamašauskienė Laura , Šitkauskienė Brigita
Published: November 2020

Pirminis imunodeficitas (PID) yra įgimtas imuninės sistemos komplemento (-ų) pokytis, lemiantis imuninio atsako nepakankamumą (išskyrus tik imunoglobulino A stoką). PID priskiriamas retoms ligoms. Pagrindinis jo požymis - dažnos, sunkios, užsitęsusios infekcijos. Infekcijų pobūdis, ligos eiga, prognozė priklauso nuo to, kuri imuninės sistemos grandis yra pažeista. Labai svarbu laiku diagnozuoti PID ir kuo greičiau pradėti gydymą. Kadangi ši liga yra reta, tiek pacientams, tiek įvairių specialybių gydytojams stinga informacijos, kada įtarti PID, ar pacientui, sergančiam šia liga, rekomenduoti skiepus, ar reikia specialių fizinio aktyvumo, kelionių, darbo apribojimų. Šio straipsnio tikslas - apžvelgti PID klasifikaciją, įspėjamuosius požymius, gydymą ir paciento, sergančio PID, kasdienio gyvenimo ypatumus bei skiepijimo rekomendacijas.
Pirfenidono veiksmingumas ir saugumas gydant idiopatinę plaučių fibrozę
Authors: Blažytė Laima , Malakauskas Kęstutis
Published: November 2020

Idiopatinė plaučių fibrozė (IPF) - tai specifinė lėtinės neaiškios kilmės ir progresuojančios fibrozinės idiopatinės intersticinės pneumonijos forma. IPF pasireiškia progresuojančiu dusuliu, prastėjančia plaučių funkcija ir siejama su bloga prognoze. Pirfenidonas yra geriamasis antifibrozinis vaistas, padedantis stabdyti plaučių funkcijos prastėjimą ir taip lėtinantis idiopatinės plaučių fibrozės progresavimą. Išsamios studijos ir tyrimai įrodė, kad ilgalaikis gydymas pirfenidonu yra saugus, veiksmingas ir puikiai toleruojamas pacientų, sergančių IPF.
Salmeterolio ir flutikazono derinio efektyvumas gydant astmą
Authors: Nutautienė Rūta
Published: November 2020

Astma yra plačiai paplitusi kvėpavimo takų uždegimo liga, kuri tinkamai nekontroliuojama blogina paciento gyvenimo kokybę ir didina išlaidas, skirtas sveikatos paslaugoms. Astmos gydymo tikslai yra gera simptomų kontrolė, normalus kasdienis paciento aktyvumas, maža rizika ir normali plaučių funkcija. Norint juos įgyvendinti, reikia laiku diagnozuoti ligą, parinkti tinkamą gydymą, ingaliatorių, suteikti pacientui informacijos, mokyti jį taisyklingos vaisto įkvėpimo technikos.
Methodology for Determination of Degree of Nodularity in a Ductile Cast Iron GGG 40 by Ultrasonic Velocity Test
Authors: Agnoletto Douglas , Lemos Guilherme Vieira Braga , Beskow Arthur Bortolini , Lessa Cleber Rodrigo de Lima , Reguly Afonso
Published: November 2020

Cast iron alloys combine many elements such as carbon, iron, silicon, magnesium and can be usually classified according to their microstructure in ductile, gray, compacted, white, and malleable. Each one has particularities in terms of properties and applications. Hence, this study aims to evaluate the degree of nodularity (%) in a ductile cast iron alloy GGG 40. In this context, a methodology to investigate the degree of nodularity was proposed. The ultrasonic method was used to determine the amount of ductile graphite as well as for parts release and thus facilitated the industrial operational execution. The effect of ultrasonic sound was investigated in sixtyseven ductile cast irons, and these analyses were further compared to the level of nodularity observed by metallography. Finally, based on the findings, the cast iron quality was guaranteed, leading to time-savings, avoiding the microstructural examination, and thus promoting cost reductions.
Niobium alloy steel applied in cold forming manufacture
Authors: Maia Bruno Inácio , Futami André Hideto , De Oliveira Marco Aurélio , Valentina Luiz Veriano Oliveira
Published: November 2020

Niobium alloy steels are still little known and debated when applied to the metallurgy industry, including cold forming process. It is not much clear about its characteristics and your mechanical performance when compared to traditional steels, which the market already uses. The possibility of input new materials, reducing costs and generating competitiveness is the basis for researches that can generate new opportunities for industries. In this article, we showed the possibility of withdrawing the heat treatment process, which guided the execution of the tests presented here. This paper deals with the performance comparison of SAE 1312 MOD steel compared to ISO 898-1, which deals with mechanical performance for bolts. The tests were correlated with the bolts of 8.8 resistance class, which currently have heat treatment. It is possible to evaluate the positive performance of the niobium-alloyed steel (SAE 1312 MOD), despite the occasional performance limitations in some attributes addressed in ISO 898-1.
Bunch number and antioxidant activity in ‘Sahebi’ and ‘Halagho’ grapes affected by pruning intensity and cane length
Authors: Mahtab Zonouri , Davood Bakhshi , Esmaeil Fallahi , Isa Arji
Published: November 2020

Pruning methods can primarily affect grape production at various levels. Of the commonly affected features by pruning, the number of bunches has known to have a significant effect on the relation between the functions of assimilate sources and sinks. Further, fruitfulness can significantly be negatively influenced by shading. In this study, we aim to study the impact of 4, 6 and 8 buds per cane with pruning intensity as light, moderate and severely pruned and their interaction in the course two consecutive years, 2017 and 2018 in ‘Sahebi’ and ‘Halagho’ (both seeded red table grape cultivars). In 2018, lightly pruned ‘Halagho’ and having 8 buds per cane increased number of bunches by 54.00, which had the highest value. Results showed that there is apical buds bear more fruit by comparison to the buds with vegetative nature, 1 to 4 first buds. Based upon the outcomes of this study, it could be concluded that due to the stresses imposed by the pruning of the vines, therefore, the chemical compounds increases in order alleviate the negative aftermaths . In 2018, whole berry antioxidant activity in both cultivars was significantly lessened, and this decline was higher in ‘Saahebi’. The number of bunches was increased by increasing cane length or bud load/cane. Overall, the pruning program has an impactful role in bunch number as well as antioxidant activity and in the long-run on accumulated reserves, which makes choosing and applying a specific pruning method undeniably important. Thus, emphasize the importance of further research in this field.
Study on the DPPH Free Radical-Scavenging Activity of Salvia Nemorosa L. At Two Growth Stages
Authors: Ghafiyehsanj Elham , Dilmaghani Kamaladdin , Chaparzade Nader , Saadatmand Sara
Published: November 2020

This study was designed to examine the DPPH free radical-scavenging activity, in different concentrations (0.025, 0.05, 0.07, 0.1, 0.2, 0.04 and 0.6) of methanolic extracts of Salvia nemorosa L. collected from the northwest of Iran (Zonouz and Ardabil regions) at two-stage of growth (vegetative stage leaves, flowering stage leaves, and flowers). The result showed that the mean of inhibition percentage in the Zonouz region increased in various concentrations and between flowers, vegetative stage leaves, and flowering stage leaves, compared with the plants of the Ardabil region. In each of the regions of Zonouz and Ardabil, the highest amount of DPPH inhibition was observed in the vegetative stage leaves in comparison with flowering stage leaves and flowers. In addition, in the effect of DPPH radical trapping in different concentrations of methanolic extracts of Salvia nemorosa L. was observed that from each of the collected region, methanolic extracts from sage plants were dose-dependent and acted very effective and useful and the best antioxidant activity was in the high concentration of extracts, So in Zonouz and Ardabil regions, the content of inhibition of DPPH increased significantly, by increasing the concentration of 0.025 mg/ml to 0.6 mg/ml and in Zonouz region the content of inhibition of DPPH similarly increased in 0.2, 0.4 and 0.6 mg/ml concentrations. In the Ardabil region, the most content of inhibition of DPPH was seen in 0.4 mg/ml and 0.6 mg/ml concentrations, but in this region, the content of inhibition of DPPH in 0.2 mg/ml concentration there was only in vegetative stage leaves and flowering stage leaves
TRUST AS A MORAL IDEAL IN CHILD-ADULT RELATIONSHIPS IN RECREATIONAL CAMPS FOR THE LEADERS OF THE PIONEER AND KOMSOMOL ORGANIZATIONS
Authors: Аджиева Е.М.
Published: November 2020

В статье представлен опыт создания атмосферы доверия в детско-взрослом сообществе лагерей актива, развития творчества, инициативы и ответственности при организации взаимодействия в детском оздоровительном лагере.
Автор проводит сравнительный анализ понятия «доверие» с позиции философии, психологии, педагогики; предлагает учитывать культурно-созидающую функцию воспитания, делового общения и взаимодействия в течение лагерной смены; конкретизирует условия проявления доверия во взросло-детском сообществе на основе анализа особенностей его проявления в лагерях пионерского и комсомольского актива, рассматривая лагерь как летнюю школу и коммуну.
В статье предложена педагогическая ретроспектива взглядов на структуру лагеря актива
и способы организации его жизнедеятельности на основе доверия, взаимовыручки, активности, ответственности.
Раскрыты особенности взаимодействия детей и взрослых в течение лагерной смены. На основе опыта конкретных лагерей по построению отношений на основе доверия сформулирован комплекс педагогических условий, определяющих особенности доверительного взаимодействия: создание коллектива, развитие самоуправления, активная жизнедеятельность
и общественная позиция, пример взрослых, положительный психологический климат, позитивный эмоциональный настрой. Перечисленные условия можно создавать не только в лагерях актива, где собираются специально выбранные дети, но и в условиях летней смены детского оздоровительного лагеря.

The article focuses on the strategy of creating the atmosphere of trust in child-adult relationships, on the strategy of enhancing creativity, initiative and responsibility at summer recreational camps for the leaders of Pioneer and Komsomol organizations.
The author comparatively analyzes the concept of trust from philosophical, psychological, and pedagogical perspectives. The author underlines the necessity of taking into consideration
the enculturating function of education and communication in a summer camp. The author describes the environment that promotes trust in child-adult relationships in recreational summer camps for the leaders of the Pioneer and Komsomol organizations.
The article performs a retrospective analysis of the structure of summer camps and of trust, mutual support, activity and responsibility as the main principles of their functioning.
It investigates the peculiarities of child-adult communication during a camp shift. It analyzes the strategies of enhancing trust used by different recreational camps to formulate a set of pedagogical prerequisites that ensure mutual trust, such as team consolidation, self-rule, vigor, social activity, adult role models, positive psychological climate, positive emotional disposition. All the above-mentioned conditions need not be limited to summer camps for the leaders of Pioneer and Komsomol organizations, these conditions can be recreated in all summer camps.
Providing Psychological and Pedagogical Support to Senior Preschool Children with Mental Retardation during a Developmental Crisis
Authors: Кисова В.В. , Юдин О.А.
Published: November 2020

В статье обозначена актуальность исследования возрастных кризисов развития у детей с ограниченными возможностями здоровья, в том числе психолого-педагогической поддержки детей с задержкой психического развития в период перехода от дошкольного к младшему школьному возрасту.
Приведены результаты диагностики дескрипторов нормативного кризиса у старших дошкольников с задержкой психического развития (внутренняя позиция школьника, произвольность поведения и деятельности, самооценка, мотивация учения).
Изложены задачи, принципы программы психолого-педагогической поддержки в период возрастного кризиса старших дошкольников с задержкой психического развития, а также основные этапы и содержание коррекционно-развивающей работы с дошкольниками: формирование внутренней позиции школьника, развитие позиционных и социальных мотивов учения, коррекция произвольности деятельности и поведения, развитие реалистичной самооценки.
Описаны результаты реализации программы коррекционной работы с экспериментальной группой дошкольников с задержкой психического развития, направленной на становление у них позитивного отношения к школе с осознанной ориентацией на формальные стороны школьной жизни, развитие начальных навыков самоконтроля на основных этапах деятельности, формирование более дифференцированной, устойчивой и реалистичной самооценки, менее зависимой от мнения референтной группы, уменьшение количества детей, демонстрирующих исключительно игровые мотивы поведения и деятельности.

The article discusses the relevance of investigating developmental crises in children with health impairments and the provision of psychological and pedagogical support to preschool children and primary school children with mental retardation.
The article provides the results of developmental crises assessment in senior preschool children with mental retardation (children’s inner characteristics, their behavioral characteristics, their self-esteem, their learning motivation).
The article focuses on the tasks, principles and strategies of psychological and pedagogical support provided to senior preschool children with mental retardation during developmental crises. It also describes the major stages and content of work with preschool children the development of children’s inner stance, their social and learning motivation, the correction of their behavior, the development of healthy self-esteem.
The article describes the results of the experimental correction of development of preschool children with mental retardation aimed at the formation of a positive image of school and studying, the development of key skills of self-control, the formation of a differentiated, stable, healthy and realistic self-esteem, fostering independence of other people’s opinions, improving children’s ability to learn.
Micro Field Study Regarding University Students’ Online Shopping Behaviours
Authors: BAYER Harun , AKSOĞAN Mustafa
Published: November 2020

The rapid spread of the Internet worldwide has created new opportunities in trade. Electronic commerce is different from the traditional trade which provides consumers access to many products as online and irrespective of time and location. However, some consumers don’t prefer electronic commerce and persist to prefer tradional trade. This study has been conducted with the aim of searching online shopping tendencies of college students. For this purpose, a conceptual framework has been created by firstly searching the domestic and foreign literature related to the subject. The study group of research consist of 403 students who studiying in Babaeski Vocational School. To collect the data, a 21-item questionnaire form developed by the researchers was used and an on-site survey method was applied. The data obtained after the questionnaire were subjected to statistical analysis and the results were interpreted. As a result of the analysis of the data; It has been observed that students prefer electronic commerce especially because it is economical. It has been seen that students mostly prefer the textile industry in electronic commerce and generally use a well-known e-commerce site. There were significant differences between the online shopping behaviours of students and the demographic factors.
The Audit Quality and Audit Delay: Evidence from Indonesia
Authors: Husain T. , Rini I Gusti Ayu Intan Saputra
Published: November 2020

Purpose: This study specifically aims to identify the impact of Audit Quality on Audit Delay. Audit Quality is measured by the proxy log natural fee audit (LNFE).

Methods: This is a causal research with quantitative analysis. This study involves six companies listed in the sub-sectors of Cable under the manufacturing sector in the Indonesia Stock Exchange for the period of 2013-2019. It applied panel data set in a regression model using STATA MP - Parallel Edition Ver14.00 application.

Results: The findings show that the Audit quality has a significant negative impact on the Audit Delay with an average delay of 83.62 days.

Implications: This study could be extended further by considering all manufacturing firms of IDX which may provide more insight into the audit quality with other proxies.
The Hα Dots Survey. II. A Second List of Faint Emission-line Objects
Authors: Salzer John J. , Feddersen Jesse R. , Derloshon Kathryn , Gronwall Caryl , Sistine Angela Van , Sugden Arthur , Janowiecki Steven , Hirschauer Alec S. , Kellar Jessica A.
Published: November 2020

We present the second catalog of serendipitously discovered compact extragalactic emission-line sources—Hα Dots. These objects have been discovered in searches of moderately deep narrow-band images acquired for the ALFALFA Hα project. In addition to cataloging 119 new Hα Dots, we also present follow-up spectral data for the full sample. These spectra allow us to confirm the nature of these objects as true extragalactic emission-line objects, to classify them in terms of activity type (star-forming or AGN), and to identify the emission line via which they were discovered. We tabulate photometric and spectroscopic data for the all objects, and we present an overview of the properties of the full Hα Dot sample. The Hα Dots represent a broad range of star-forming and active galaxies detected via several different emission lines over a wide range of redshifts. The sample includes Hα-detected blue compact dwarf galaxies at low redshift, [O iii]-detected Seyfert 2 and Green Pea-like galaxies at intermediate redshifts, and QSOs detected via one of several UV emission lines, including Lyα. Despite the heterogeneous appearance of the resulting catalog of objects, we show that our selection method leads to well-defined samples of specific classes of emission-line objects with properties that allow for statistical studies of each class.
Année 2020 : le monde « constellaire » des avocats
Authors: Saint-Pierre François
Published: November 2020

Au seuil des années 2020, le monde des avocats vit une évolution spectaculaire. Leur nombre n'a cessé d'augmenter depuis plusieurs décennies, la plupart se sont spécialisés dans les différents domaines juridiques, développant leurs cabinets suivant des règles ultra-libérales, sous des formes très variées. L'année 2020, marquée par la grande grève pour la défense de leur système de retraites et la crise sanitaire, aura-t-elle altéré, voire brisé son dynamisme ? Je ne le crois pas. Le barreau a une histoire ancienne et une fonction sociale essentielle. Les avocats réinventent leur métier à chaque époque et continueront sans doute de le faire à l'avenir. Aussi divers soient-ils, une valeur commune les réunit : la défense de leurs clients, et une certaine idée du droit, de l'État de droit.
L'avocat dans ses relations avec les autres professions judiciaires
Authors: Morineau Amélie
Published: November 2020

À travers son expérience personnelle et son activité militante, Amélie Morineau présente dans cet article un état des lieux alarmant des relations entre les avocats et les autres professions judiciaires, au premier rang desquelles la magistrature. Face à la détérioration générale des conditions de travail de l'ensemble de ces professions, l'auteure fait état du manque de communication interprofessionnelle et surtout de la méconnaissance pour les différents protagonistes des conditions réelles d'exercice du métier de chacun. Elle regrette que les uns et les autres soient manifestement incapables de surmonter leurs divisions pour imposer au Gouvernement, d'aujourd'hui comme d'hier, d'entendre le cris d'alarme de l'ensemble du monde judiciaire. Amélie Morineau pointe du doigt les responsabilités de chacun dans ce délitement des conditions d'exercice des métiers de la Justice et appelle à une plus large coopération basée sur une foi du palais qui semble à regret disparaître.
L'avocat juge et partie
Authors: Travers de Faultrier Sandra
Published: November 2020

Qu'il plaide ou qu'il élabore un contrat ou conseille, l'avocat est le premier juge d'un dossier. Car c'est à partir de cette qualification première des faits qu'il pourra développer son argumentation. Une qualification qui le fait juge des faits et qui peut aussi le faire juge du droit, ouvrant ainsi une voie à la prise en compte objective du temps comme à l'idée « subjective » du droit que peut sous-tendre l'attachement à une discipline. Entre neutralité indifférente et subjectivité affaiblissante, le « moi de l'avocat » sous le masque de la technicité distante travaille silencieusement une écriture de l'ajustement.
Les décisions disciplinaires du Conseil supérieur de la magistrature vues par le Conseil d'État
Authors: Lapouble Jean-Christophe
Published: November 2020

Le Conseil Supérieur de la Magistrature est chargé d'assurer la discipline des magistrats judiciaires afin de s'assurer du bon respect de leurs obligations professionnelles. Les sanctions prises font l'objet d'un contrôle par le Conseil d'État en application d'une jurisprudence prétorienne jamais remise en cause. Une telle compétence comme juge de cassation n'est pas sans interroger quand on examine l'organisation des mesures disciplinaires pour les magistrats administratifs qui bénéficient d'un régime sensiblement différent dont la transparence laisse à désirer.
Faraway So Close: Epichoric Features and “International” Aspirations in Archaic Greek Epigram
Authors: Kaczko Sara
Published: November 2020

Les poèmes épigraphiques montrent des liens très étroits avec le contexte local dans lequel ils étaient « exposés » et pour lequel ils étaient conçus. Les différents contextes locaux exerçaient, tant en termes visuels que littéraires, une influence sur la langue de ces monuments gravés. Le contexte épichorique était d’une telle importance que même les formules homériques étaient adaptées pour refléter la phonétique locale. Parallèlement, dans des occasions différentes et sous des conditions variables, qui normalement sont associées à une aspiration au prestige et/ou au « cosmopolitisme », les aspects autochtones d’une inscription, dans son apparence archéologique, épigraphique ou littéraire, étaient minimisés en faveur des caractéristiques non locales. Cette contribution se concentre sur quelques cas qui illustrent ce phénomène de manière saillante.