bluuebunny/crossref_metadata_2025 huggingface dataset:
Image registration analysis of the motion characteristics of sternoclavicular joints in sagittal motion of the upper limbs
Authors: Su Peng , Zhou Junlin , Yun Cai , Liu Feng , Zhang Yi
Published: January 2021

OBJECTIVE: This study aims to accurately measure the range of motion of the sternoclavicular (SC) joint using 3D reconstruction and image registration. The motion of the SC joint is analyzed by means of axial angle representation to identify the kinematical characteristics of this joint. METHODS: A total of 13 healthy volunteers were enrolled in the study. The limit postures of four SC joint movements were scanned by computerized tomography. The images were integrated with reconstruction and registration techniques. The range of motion of the SC joint was measured using 3D modelling. The axial angle was used to indicate the range of motion of the SC joint. The difference between the dominant side and non-dominant side was compared and the differences in axial angle of the SC joint in different postures were compared. RESULTS: The active axial angle of the SC joint on the dominant side was approximately 1∘ higher than that of the non-dominant side when the upper limb moved from a rest position to a posteroinferior position. In the sagittal motion of the upper limbs, the axial angle of the SC joint was greatest when moving from a horizontal position to a posterosuperior position, with an average of 23.55∘. Of the flexion and extension movements of the upper limbs from a rest position to a horizontal position, 13.66% (the smallest proportion) were completed by the SC joint. CONCLUSION: The combination of 3D reconstruction and image registration is a direct and accurate method of measuring the motion of the SC joint. Axial angle representation is an intuitive method of expressing rotation in a 3D space that allows for more convenient comparison; it is also more in line with the characteristics of human anatomy and kinesiology and therefore more accurately reflects the characteristics of joint motion. It is therefore useful for guiding clinical practice. In a physical examination, the extension of the upper limb from the horizontal position to the posterosuperior position and from the rest position to the posteroinferior position can best reflect the rotation function of the SC joint in the combined motion of shoulder joints.
Perancangan Sistem Informasi Pendaftaran Siswa Baru di SMK YASTRIF 1 Parung Panjang Berbasis Web
Authors: Ismi Ismi , Willis Ratna , Soliah Siti , Tiawati Iyus , Yulianti Yulianti
Published: January 2021

In this millennial era, the development of technology has really sped up the difference compared to the previous era. Every day, even at the clock, there are always new developments in technology. Invarious fields, everything wants to be practical and fast, all of that cannot be separated from new discoveries from technology plus millennials who want everything instant and fast. People nowadays are almost all technology literate, one of which is the internet. Just by sitting pretty and connected to the internet, everything can be done without having to leave the house. Parents and school children don't have to bother queuing just to register for school, just open the internet, everything can be done at any time. This study aims to make it easier for new students who are millennials by building online media, namely websites using the HTML programming language, MySQL database. Prospective students only need to be connected to the internet and can register for schools and be more efficient.
Aplikasi Pengarsipan Surat Masuk dan Surat Keluar Berbasis Web pada SMP Negeri 32 Pekanbaru
Authors: Yulisman Yulisman , Wahyuni Refni , Irawan Yuda
Published: January 2021

Archiving incoming and outgoing mail is very important in an organization, especially for institutions such as SMP Negeri 32 Pekanbaru. The filing of letters at SMP Negeri 32 Pekanbaru is still done by writing incoming and outgoing letters on the agenda book and storing letters in filing cabinets, making it difficult to find old letter archives and often losing letters. The purpose of this research is to find the right solution so that the archiving of incoming and outgoing mail at SMP Negeri 32 Pekanbaru is more effective and efficient by making an application for archiving incoming and outgoing mail. The method used in this research is the system development model method, namely the Waterfall Model. The application design and analysis model uses the UML (Unified Modeling Language) model which is an object-oriented language or OOP (Object Oriented Programming). Application development and development uses a static programming language, namely PHP (Hypertext Pre-processor) and MySQL as application database. The results of the research on the making of incoming and outgoing mail archiving applications are very helpful and easier for SMP Negeri 32 Pekanbaru in filing incoming and outgoing mail, especially the Administration (School Administration) section because letter archiving is already stored in the database. The conclusion is that the application is very easy and helpful in archiving incoming mail and this letter is evident from the user's assessment of the application with a value of 92% more effective and efficient.
Analisis Kinerja Keuangan Terhadap Price Earning Ratio (PER)
Authors: Jusmansyah Muhamad
Published: January 2021

In investment activities an investor must have the ability to carry out stock analysis and one of the method who used to analyze a stock is fundamental analysis. According to that things, The intention to carry out a study is to be able to determinate The results of the balance sheet analysis have an impact PER in Public Companies Manufacturing Food and Beverages Sub Sector and research period is 2014-2018. This research uses four variable which are thought to effect PER is CR, DER, TATO, and ROE. This research used secondary data with total of sample is 12 companies. Purposive Sampling is method who used for this research. due to this analysis gives meaning ROE have a significant effect to PER while the variables CR, DER, and TATO have insignificant effect to PER. The Determination Coefficient is 0.534 which means that 53.4 % of PER is determinated by independent variable CR, DER, TATO, and ROE. While the remaining 0.466 or 46.6 % is explained by other variable outside the research
PENGARUH PROMOTION MIX DAN PRODUCT MIX TERHADAP VOLUME PENJUALAN
Authors: Hendriyani Putri , Sume Syahlan A , Kuraesin Ecin
Published: January 2021

Tujuan penelitian ini adalah untuk mengetahui pengaruh promotion mix dan product mix terhadap volume penjualan pada PT Sanprima Sentosa Bogor.
Dalam penelitian ini data yang diolah adalah data kuantitatif, data yang digunakan adalah data sekunder perusahaan. Metode analisis data yang digunakan adalah dengan analisis regresi linier berganda, analisis korelasi berganda, koefisien determinasi dan uji hipotesis, sedangkan pengolahan data menggunakan SPSS 21.0 for windows.
Dari hasil pengolahan data diperoleh persamaan regresi linier berganda Y = 10744,735 + 4,076X1 + 12,746X2. Dari hasil analisis koefisien korelasi R = 0,987 terletak pada interval (0,80- 1,000),hal ini menunjukan bahwa hubungan antara variabel X1 (persepsi terhadap promotion mix) dan X2 (persepsi terhadap product mix) adalah sangat kuat dan positif. Dari hasil koefisien determinasi yang disesuaikan sebesar 95,0%. Selanjutnya dari hasil uji
22
hipotesis pada taraf kesalahan 5% adalah F hitung = 39,175 > F tabel = 19,00, maka Ho ditolak (Ha diterima) berarti bahwa terdapat pengaruh yang signifikan antara Promotion Mix dan Product Mix secara bersama-sama terhadap Volume Penjualan.
PENGARUH MOTIVASI DAN KEPUASAN KERJA TERHADAP KINERJA KARYAWAN
Authors: Latifah Erni , Agung Syahrum , Rinda Rachmatullaily Tinakartika
Published: January 2021

Penelitian ini bertujuan untuk mengetahui sejauh mana Pengaruh Motivasi dan Kepuasan Kerja terhadap Kinerja Karyawan.Penelitian ini menggunakan Motivasi dan Kepuasan Kerja sebagai variabel independen, dan Kinerja Karyawan sebagai variabel dependen. Tujuan penelitian ini adalah untuk menguji dan menganalisis Pengaruh Motivasi dan Kepuasan Kerja Terhadap Kinerja Karyawan. Dalam penelitian ini jumlah populasi sampel yang digunakan sebanyak 50 karyawan.Hasil analisis data menggunakan SPSS dengan hasil R = 0,718. Hasil ini menunjukan bahwa terdapat pengaruh yang sangat kuat dan positif antara variabel Motivasi (X1) dan variabel Kepuasan Kerja (X2) terhadap variabel Kinerja Karyawan (Y). Analisis menggunakan uji F, menunjukan F hitung = 24,992 > F tabel 3,20 maka Ho ditolak Ha diterima, berarti terdapat pengaruh yang signifikan dengan menunjukan adanya pengaruh yang signifikan antara Motivasi dan Kepuasan Kerja terhadap Kinerja Karyawan.
PENGARUH CITRA MEREK, KUALITAS PELAYANAN, DAN PERSEPSI HARGA TERHADAP MINAT BELI ULANG KONSUMEN
Authors: Rasmana Firda Anggun Septiana , Eldine Achyar , Muniroh Leny
Published: January 2021

Tujuan penelitian ini untuk mengetahui pengaruh citra merek, kualitas pelayanan, dan
persepsi harga terhadap keputusan pembelian ulang konsumen pada Restoran Ayam Asix
Semeru Bogor. Metode yang digunakan adalah riset kepustakaan, penelitian lapangan dengan
kuesioner,dan wawancara. Penelitian dilakukan di Jalan DR. Sumeru blok H4&H5. Kec
Bogor Barat Kota Bogor. Sedangkan waktu penelitian ini dilaksanakan pada 1 Juli 2019
hingga 31 Juli 2019. Hasil Penelitian diperoleh persamaan regresi linier berganda Y = 0,556
+ 0,252X1 + 0,430X2 + 0,423X3. Hasil analisis simultan (uji f) didapatkan f hitung sebesar
37,564 dan t hitung untuk variabel citra merek sebesar 0,417 dengan tingkat signifikansi
0,677, t hitung untuk variabel kualitas pelayanan sebesar 1,995 dengan tingkat signifikansi
0,049, t hitung untuk variabel persepsi harga sebesar 3,324 dengan tingkat signifikansi 0,001,
t hitung untuk variabel minat beli ulang konsumen sebesar 2,624 dengan tingkat signifikansi
0,010. Simpulan dari penelitian ini adalah adanya pengaruh secara parsial dan simultan antara
citra merek, kualitas pelayanan, dan persepsi harga, terhadap minat beli ulang konsumen.
PENGARUH NET PROFIT MARGIN DAN EARNING PER SHARE TERHADAP HARGA SAHAM
Authors: Ramadan Dicky , Yudhawati Diah , Supramono Supramono
Published: January 2021

Penelitian ini bertujuan untuk meneliti pengaruh Net Profit Margin terhadap harga saham, pengaruh Earning per share terhadap harga saham, pengaruh Net Profit Margin dan Earning per share terhadap harga saham perusahaan dan variabel mana yang memberikan pengaruh yang signifikan terhadap harga saham perusahaan. Dalam penelitian ini menggunakan analisis deskriptif melalui perhitungan rata-rata (mean), nilai maksimum dan minimum sehingga diperoleh gambaran mengenai data sampel dengan menggunakan metode penarikan sampel. Sampel dalam penelitian ini sebanyak 4 perusahaan dengan menggunakan analisa setiap variabel pada masing-masing perusahaan yaitu analisis : Net Profit Margin (NPM), Earning Per Share (EPS), harga saham, serta uji asumsi klasik statistik, uji regresi linier berganda dan uji koefisien korelasi dan determinasi. Hasil penelitian dengan menggunakan uji t dengan nilai signifikansi 0,000 < 0,05 disimpulkan bahwa secara parsial variabel EPS berpengaruh secara signifikan terhadap harga saham, sedangkan variabel NPM memperoleh nilai t dengan signifikan 0,098 < 0,1 disimpulkan bahwa NPM berpengaruh secara signifikan terhadap harga saham. EPS mempunyai pengaruh yang signifikan terhadap harga saham pada perusahaan yang termasuk dalam perusahaan Sub Sektor Otomotif dan komponen yang terdaftar di Bursa efek Indonesia. Secara simultan dengan menggunakan uji F nilai F hitung 52,526 > F tabel 3,44 dengan nilai signifikansi 0,000 < 0,05 menunjukkan bahwa NPM dan EPS berpengaruh secara signifikan terhadap harga saham.
PENGARUH ANALISIS PEKERJAAN DAN STRUKTUR ORGANISASI TERHADAP KINERJA KARYAWAN
Authors: Ismadinah Syifa , Firdaus Muhamad Azis , Marlina Asti
Published: January 2021

Tujuan penelitian ini akan menggambarkan seberapa besar pengaruh Analisis Pekerjaan dan Struktur Organisasi terhadap Kinerja Karyawan pada BPRS Amanah Ummah Pusat. Metode survei yang digunakan pada penelitian ini adalah dengan menggunakan data primer yang diperoleh dari kueisoner dan data sekunder diperoleh dari link resmi BPRS Amanah Ummah yang ada pada internet. Sampel pada penelitian ini adalah 42 orang responden pegawai BPRS Amanah Ummah Pusat.Hasil analisis menunjukan pengaruh analisis pekerjaan terhadap kinerja dengan nilai uji T hipotesis parsial dengan Thitung = 6,052 > Ttabel = 1,683, maka Ho ditolak (Ha diterima) berarti terdapat pengaruh yang signifikan antara Analisis Pekerjaan terhadap Kinerja. Hasil analisis menunjukan pengaruh struktur organisasi terhadap kinerja dengan nilai uji T hipotesis parsial dengan Thitung = 3,635 > T tabel = 1,683 maka Ho ditolak (Ha diterima) berarti bahwa terdapat pengaruh yang signifikan antara Struktur Organisasi (X2) dan terhadap Kinerja (Y). Hasil analisis pengaruh analisis pekerjaan dan struktur organisasi terhadap kinerja dengan nilai uji hipotesis dengan Fhitung = 18,233 > F tabel = 3,24, maka Ho ditolak (Ha diterima) berarti bahwa terdapat pengaruh yang signifikan antara Analisis Pekerjaan dan Struktur Organisasi secara bersama-sama terhadap Kinerja.
Evaluation of Seed Production and Quality Performance of Onion (Allium Cepa L.) Varieties at Kulumsa in Arsi Zone South East Ethiopia
Authors: Fufa Nimona , Gebretensay Fekadu , Tsagaye Dasta , Fikre Demis , Wegayehu Gizaw , Ali Awoke
Published: January 2021

Field experiment involving five improved onion (Allium cepa L.) varieties and carried out at Kulumsa Agricultural Research Center during the 2018 to 2019 cropping seasons under irrigated condition to identify the best performing variety for seed production to the target areas of Arsi Zone. The onion varieties included in the field experiment were (Nafis, Robaf, Nasic Red, Bombe Red, and Adama Red). The experimental design was a randomized complete block design (RCBD) with three replications. Phenological and growth parameters, seed yield, and yield components were studied. The result showed that Variety had a significant effect on most phonological and growth attributes as well as on yield attributes. The number of days to flowering and vigorously were significantly affected by variety; while plant height, days to boolting and branch number was not significantly influenced by variety. Flower stalks height and diameter, number of umbel per plant, and umbel diameter also significantly affected by variety. Seed yield per umbel and mean seed yield per hectare also showed a significance difference among varieties. The highest seed yield per hectare (1415.89 kg/ha) was recorded from Adama Red and followed by Nafis variety, whereas Nasic rerd, Bombe red and Robaf show no significance difference among each other, Therefore, it can be concluded that use of the improved onion varieties such as Adama red and Nafis is advisable and could be appropriate for onion seed production in the test area even though further testing is required to put the recommendation on a strong basis.
Scientific Publishing in a Pandemic
Authors: Boyle Malcolm
Published: January 2021

Worldwide, 2020 was a difficult and challenging year for everyone, including for publishers of scientific journals. Many journals had difficulty sourcing reviewers because people were busier in unexpected ways and could not review a manuscript, or those who were able to review a manuscript often struggled to get it done in the prescribed time due to work and personal commitments.

Even with this challenging year, the AJP published 51 research-related articles, slightly more than in 2019. We are confident that 2021 will also prove to be a positive in a publishing sense as we continue to receive manuscripts from national and international authors covering a broad range of topics.

So, as we enter another year of uncertainty, the AJP's editorial team look forward to meeting the challenges of 2021 as we continue to publish peer-reviewed articles from Australasia and around the world.
Dampak Work From Home Selama Pandemi Covid-19 terhadap Kondisi Fisiologis dan Perilaku Komunikasi
Authors: Putra Fajar Dewanto
Published: January 2021

The Covid-19 pandemic brought a variety of major changes to human social life throughout the world, including in Indonesia. The situation requires the government to impose work activities from home or known as WFH (working from home). Such a situation changes the behavior of human communication, which at first more often uses direct interaction directly, now changes to use digital media, thus creating a kind of social shock in the communication process. Furthermore, such changes take place over an uncertain period of time, so it is possible to raise a number of problems, related to personal conditions, which then affect communication behavior. This article seeks to find out the effect of applying work from home policies on physiology to communication behavior, using qualitative methods with a participatory approach, by observing changes in physiological conditions and individual communication behavior. Thus, this article is expected to reveal the hidden impact of the application of work from home, on physiological conditions and communication behavior.

Keywords: Covid-19, Work from home, Communication behavior, Physiology, Communibiology
Domestication of Women in Dettol Soap Commercials
Authors: Qorib Fathul , Saekoko Aploisari , Setiamandani Emei Dwinanarhati
Published: January 2021

Mass media is one of the most frequently used promotional tools by industry. Unfortunately, advertising not only contains product marketing but also spreads unfair ideas towards women, especially beauty product advertisements. Ramadan Bersih's version from Dettol Soap advertisement depicts a family containing a husband, wife, and children with their respective roles. This study focuses on women's role as housewives in advertisement using gender theory and Roland Barthes' semiotic model. The study found a tendency to place women as housewives responsible for cleaning the house, cooking, supervising children, educating, maintaining children's righteousness, and washing. This study strengthens the previous study's findings regarding women's domestication in advertising. In conclusion, advertising builds a household member's conception role in an unbalanced gender distinction. As a cultural product consumed by the wider community, the industry should pay more attention to advertisements designed to sell goods without eliminating gender education and justice elements
PENGASUHAN JARAK JAUH PADA ANAK PEREMPUAN YANG DITINGGAL MERANTAU ORANG TUA TERHADAP PERILAKU SOSIAL ANAK
Authors: Feriwati Retno Ayu
Published: January 2021

AbstrakDi dalam sebuah keluarga, orang tua mempunyai kewajiban untuk mengasuh serta mendidik anak-anaknya agar dapat menjadi manusia yang berdaya guna. Pengasuhan orang tua sangat penting dalam keluarga, melalui proses internalisasi yang dilakukan oleh orang tua kepada anak, diharapkan anak akan tumbuh menjadi pribadi yang bisa diterima masyarakat. Adanya fenomena migrasi yang hampir terjadi di setiap daerah, memunculkan berbagai permasalahan salah satunya berkaitan dengan dampak anak yang ditinggal merantau oleh orang tua. Orang tua di dusun Bedug yang pergi merantau ke luar daerah biasanya menitipkan anak mereka kepada nenek maupun kerabat dekat lainnya. Sehingga orang tua seringkali tidak terlibat secara penuh dalam mendidik dan mengontrol sang anak karena terpisahkan oleh jarak. Penelitian ini bertujuan untuk mengetahui penerapan pengasuhan jarak jauh yang dilakukan orang tua kepada anak perempuan yang ditinggal merantau serta dampak pengasuhan jarak jauh tersebut terhadap perilaku sosial anak perempuan yang ditinggal merantau. Penelitian ini merupakan penelitian kualitatif dengan menggunakan pendekatan studi kasus. Berdasarkan hasil penelitian, orang tua yang pergi merantau di dusun Bedug akan melakukan pengasuhan secara tidak langsung yakni dengan memanfaatkan teknologi komunikasi seperti dengan bertelepon maupun video call. Tidak adanya kehadiran orang tua secara langsung dalam mengasuh dan mendidik anak membuat fungsi Integration (Integrasi) tidak berjalan sesuai semestinya atau rusak. Akibatnya, hal ini membuat sang anak bertindak sesuka hati karena kurangnya pengawasan serta kontrol dari orang tua. Dari penelitian ini dapat disimpulkan bahwa pengasuhan jarak jauh yang diterapkan oleh orang tua yang merantau berdampak pada perilaku sosial anak perempuan yang ditinggal merantau.Kata Kunci : Jarak Jauh, Merantau, Pengasuhan, Perilaku Sosial
Representations of gender in executive offices
Authors: Modesto Filho Jair , Vieira Adriane , Carrieri Alexandre de Pádua
Published: January 2021

Based on the critical discourses analysis, this study reached the goal of thinking about what was said and not said concerning the attributes of masculinity and femininity that configure the modes of management in organizations. This research is based on the analysis of discourse as the objective of understanding the meaning of the enunciation by means of the enunciative marks given and not mentioned. Eight semi-structured interviews were conducted based on a guiding script. A technique used to select the subjects was the snowball. What was said by four male managers and four female managers confirms that for women the male attributes are best suited for the management, and for men feminine attributes as emotional involvement and commitment contribute to a more humanized management. What is implied is that the male predominance in management positions is due to the inability of women conquer the professional spaces as men, because they do not have the right genetic heritage or because they need to be protected by men, who are ‘natural born leaders’.
Tratamento incruento de fraturas nasais isoladas em adultos: uma revisão integrativa
Authors: Oliveira Anna Carolina Jaccottet , Linn Gabriel Luiz , Conci Ricardo Augusto , Érnica Natasha Magro , Garbin Junior Eleonor Álvaro , Jandrey Valeria Juliana , Pavelski Mateus Diego , Griza Geraldo Luiz
Published: January 2021

O presente estudo objetiva apresentar informações atuais e relevantes sobre o tratamento incruento de fraturas nasais isoladas em adultos, concernentes à área de cirurgia e traumatologia buco-maxilo-facial. Para tal, foi realizado um levantamento bibliográfico de trabalhos completos publicados em inglês, espanhol ou português, no período de janeiro de 2015 a setembro de 2020, nas bases de dados MEDLINE, LILACS e BBO. Após realização da busca e aplicação dos critérios de inclusão e exclusão, obteve-se uma amostra de 12 artigos, cujas informações foram discutidas em 3 categorias diferentes, de acordo com seus respectivos assuntos. Diante da realização desse estudo, pôde-se observar que diversos trabalhos vêm sendo realizados, de forma a facilitar o manejo e melhorar os resultados em reduções incruentas de fraturas nasais isoladas em adultos. Dessa forma, cabe ao cirurgião buco-maxilo-facial fazer uso de informações atuais presentes na literatura, objetivando abandonar práticas obsoletas e proporcionar uma experiência mais satisfatória aos pacientes.
Oral cavity bleeding following snakebite: A case report
Authors: Oliveira Mirlany Mendes Maciel , Almeida Lorena Mendes , Santos Daniela Meneses , Silva Marcelo Caetano Parreira da , Silva Claudia Jordão , Zanetta-Barbosa Darceny , Batista Jonas Dantas , Lima Felipe Gomes Gonçalves Peres , Rios Larissa Gonçalves Cunha
Published: January 2021

Snakebite is an important public health problem because of its incidence, morbidity, and mortality. It may be related to climatic factors and rural habits. Snakes of the genus Bothrops are responsible for most snakebites in Brazil. The venom of these snakes has peculiar characteristics, with important proteolytic, coagulant, and hemorrhagic actions, leading to local and systemic alterations. Initial manifestations include local tissue injury, pain, swelling, bleeding, and bullous lesions that can progress to abscesses or tissue necrosis. Systemic manifestations should be carefully evaluated especially for the probability of hemorrhagic events such as epistaxis, gingivorrhagia, hematuria, and hemoptysis. Knowing the clinical manifestations of snakebites, as well as the adequate treatment, is essential. Efficient and rapid diagnosis can minimize victims’ injuries and the probability of death. The present study reports the clinical case of bleeding at a distant site from the initial site of venom inoculation after bite by a Bothrops snake, emphasizing the therapeutic approach and differential diagnosis in these cases.
Simple method for long-term recording of electrocardiogram signals in prawns
Authors: Lin HT , Chen TC , Chang JP , Chou ZY , Chiou SY , Tsai ML
Published: January 2021

This paper presents a novel approach to the long-term recording of electrocardiogram (ECG) signals in prawns, including a 3-lead electrode, a lightweight external wires assembly, a waterproof electrode-wire junction, and a standardized implanting procedure. The proposed low-cost device is easily constructed, even by untrained undergraduate students, using common laboratory materials. Consistent ECG recordings were obtained over a period of 72 h in experiments on 6 freely moving prawns (Macrobrachium rosenbergii). A subsequent experiment conducted continuously for 38 d revealed that despite gradual attenuation the ECG signals could still be identified (signal-to-noise ratio ≥3). The prawns survived implantation and later underwent natural molting, whereupon the electrode was successfully re-implanted. The proposed electrode is a valuable tool by which to gain insight into the long-term physiological state of crustaceans.
REKAYASA PERANGKAT LUNAK PRODUK INOVASI, HAK KEKAYAAN INTELEKTUAL, DAN INKUBATOR BISNIS DENGAN METODE USER CENTERED DESIGN: STUDI KASUS UNIVERSITAS BINA DARMA
Authors: Wahyudi Ifran , Muzakir Ari
Published: January 2021

Abstract :  The Directorate of Innovation and Business Incubator is part of Bina Darma University which facilitates tenants to get incubations from partners who collaborate with Bina Darma University. This research was conducted with the aim of creating an information system that can solve existing problems, namely building a web-based information system and Progressive Web Apps (PWA) using the Codeigniter and Materialize framework, which is an information system designed to manage all data collection. Tenants, activity data collection, document storage, and other data in the Directorate of Innovation and Business Incubator, and can display the required information reports quickly and efficiently. By using the Focus Group Discussion (FGD) method, researchers get feedback from clients by discussing, and researchers can create systems with the best implementation to meet client needs. The results of this study are the availability of a information system that can assist users in managing all tenant data collection, activity data collection, documentation, and data on innovation products and intellectual property rights at the Directorate of Innovation and Business Incubator at Bina Darma University.
„Itt kezdődött a posztmodern?”
Authors: Fűzfa Balázs
Published: January 2021

Az irodalmi regionalitás kérdései mindig is érdekelték a kutatókat, ám – néhány kivételtől eltekintve – ez a szempont mégsem vált sem az irodalomtudomány, sem az irodalomtanítás kiemelt területévé (utóbbiban 2005, azaz a kétszintű érettségi bevezetése óta szerepel). A szerző hipotetikusan a XX. század kanonikus világirodalmi műveire (Joyce, Musil, Rilke), illetve azok poétikai hasonlóságaira alapozza kijelentését, mely szerint az irodalmi modernség egyik bölcsője a Borostyánkőút Európán átívelő kulturális csatornája lehetett, melynek szerves része a magyar irodalom is – elsősorban Ottlik Géza Iskola a határon című regénye révén. Ottlik műve éppen azt a korszakot dolgozza fel (1923–1926), melyben karakterisztikusan megjelentek a posztmodern poétika jegyei: a mellérendeltség, a párhuzamos nézőpontok, az idősíkok felbontása stb. Például a „Trieszti-öböl” (Joyce, Ottlik) tehát úgy lesz a modernség bölcsője, hogy Duinótól (Rilke) Trieszten és Szombathelyen (Joyce), továbbá Kőszegen (Ottlik) át ível az út Bécsig (Musil) és Prágáig (Kafka). Ebből pedig kiemelhető (sok más mellett) egy olyan tematikus problémasor, mint például a „katonaiskolás szerző”-k lehetséges néző-pontja; amely lényegében nem más, mint egy velük azonos korban alkotó irodalomtudós determináns szempontja, jelesül a katonaiskola-szövegek „kronotoposz” meghatározta jellege (Bahtyin).A címben jelzett fő hipotézis („Itt kezdődött a posztmodern...”) akár túlzónak vagy játékosnak is mondható, ám a szerző reménykedik benne, hogy nézőpontja néhány adalékkal hozzájárulhat a szóban forgó kiskorszak poétikai világának értelmezéséhez.
Phytonematodes Associating Wheat in North Eastern Egypt and Pathogenicity of Heterodera avenae on Certain Cereal Cultivars
Authors: Abdel-Baset Sahar H. , Dawabah Ahmed A. M.
Published: January 2021

A survey of plant-parasitic nematodes (PPNs) associating wheat in Ismailia governorate, northeastern Egypt was carried-out during 2016/2017 and 2017/2018 growing seasons. Results showed that seven PPNs genera and/or species were found associating wheat roots. These genera and/or species, in descending order of frequency, were: Tylenchorhynchus spp. (14%), Helicotylenchus spp. (10%), Heterodera avenae (8%), Ditylenchus spp. (5%), Meloidogyne javanica (4%), Pratylenchus spp. and Xiphinema spp. (3%, each). Two screening pot experiments, in two consecutive growing seasons (2017/17 and 2017/18) were carried out to determine the host suitability of 15 Egyptian cereal cultivars including bread wheat (Triticum aestivum), barley (Hordeum vulgare) and oat (Avena sativa) to the cereal cyst nematode, Heterodera avenae, under greenhouse conditions. Results of both experiments were very similar and showed that oat cv. Baladi and wheat cv. Giza 171 were highly susceptible, while wheat cvs. Masr 1, Masr 2, Masr 3, Sakha 95, Seds 1, Seds 12, and Shandawel 1 were susceptible. However, barley cvs. Giza 135, Giza 123, Giza 124, and Giza 125 were found to be moderately resistant to the tested nematode. H. avenae suppressed (P ≤ 0.05) the dry weights of roots, shoots and spikes of the inoculated plants, compared to the non-inoculated checks. Another greenhouse pot experiment was carried out during the wheat-growing season 2018/2019 to determine the effect of different initial population densities (Pi) of H. avenae on the growth parameters of wheat cv. Giza 171 and on nematode reproduction. Results showed that as the nematode Pi increased, both the wheat growth parameters and the nematode reproduction factor (Rf) were decreased (P ≤ 0.05).
Utilizing Frémy's Salt to Increase the Mechanical Rigidity of Supramolecular Peptide-Based Gel Networks
Authors: Fichman Galit , Schneider Joel P.
Published: January 2021

Peptide-based supramolecular gels are an important class of biomaterials that can be used for biomedical applications ranging from drug delivery to tissue engineering. Methodology that allows one to readily modulate the mechanical properties of these gels will allow yet even a broader range of applications. Frémy's salt is an inorganic salt and long-lived free radical that is known to oxidize phenols. Herein, we show that Frémy's salt can be used to dramatically increase the mechanical rigidity of hydrogels formed by tyrosine-containing self-assembling β-hairpin peptides. When Frémy's salt is added to pre-formed gels, it converts tyrosine residues to o-quinones that can subsequently react with amines present within the lysine side chains of the assembled peptide. This results in the installation of chemical crosslinks that reinforce the gel matrix. We characterized the unoxidized and oxidized gel systems using UV-Vis, transmission electron microscopy and rheological measurements and show that Frémy's salt increases the gel rigidity by nearly one order of magnitude, while retaining the gel's shear-thin/recovery behavior. Thus, Frémy's salt represents an on-demand method to modulate the mechanical rigidity of peptide-based self-assembled gels.
Mitochondrial Metabolism in the Intestinal Stem Cell Niche—Sensing and Signaling in Health and Disease
Authors: Urbauer Elisabeth , Rath Eva , Haller Dirk
Published: January 2021

Mitochondrial metabolism, dynamics, and stress responses in the intestinal stem cell niche play a pivotal role in regulating intestinal epithelial cell homeostasis, including self-renewal and differentiation. In addition, mitochondria are increasingly recognized for their involvement in sensing the metabolic environment and their capability of integrating host and microbial-derived signals. Gastrointestinal diseases such as inflammatory bowel diseases and colorectal cancer are characterized by alterations of intestinal stemness, the microbial milieu, and mitochondrial metabolism. Thus, mitochondrial function emerges at the interface of determining health and disease, and failure to adapt mitochondrial function to environmental cues potentially results in aberrant tissue responses. A mechanistic understanding of the underlying role of mitochondrial fitness in intestinal pathologies is still in its infancy, and therapies targeting mitochondrial (dys)function are currently lacking. This review discusses mitochondrial signaling and metabolism in intestinal stem cells and Paneth cells as critical junction translating host- and microbe-derived signals into epithelial responses. Consequently, we propose mitochondrial fitness as a hallmark for intestinal epithelial cell plasticity, determining the regenerative capacity of the epithelium.
Roles of the Wnt Signaling Pathway in Head and Neck Squamous Cell Carcinoma
Authors: Xie Jing , Huang Li , Lu You-Guang , Zheng Da-Li
Published: January 2021

Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck tumor. It is a high incidence malignant tumor associated with a low survival rate and limited treatment options. Accumulating conclusions indicate that the Wnt signaling pathway plays a vital role in the pathobiological process of HNSCC. The canonical Wnt/β-catenin signaling pathway affects a variety of cellular progression, enabling tumor cells to maintain and further promote the immature stem-like phenotype, proliferate, prolong survival, and gain invasiveness. Genomic studies of head and neck tumors have shown that although β-catenin is not frequently mutated in HNSCC, its activity is not inhibited by mutations in upstream gene encoding β-catenin, NOTCH1, FAT1, and AJUBA. Genetic defects affect the components of the Wnt pathway in oral squamous cell carcinoma (OSCC) and the epigenetic mechanisms that regulate inhibitors of the Wnt pathway. This paper aims to summarize the groundbreaking discoveries and recent advances involving the Wnt signaling pathway and highlight the relevance of this pathway in head and neck squamous cell cancer, which will help provide new insights into improving the treatment of human HNSCC by interfering with the transcriptional signaling of Wnt.
Light Sheet Microscopy Using FITC-Albumin Followed by Immunohistochemistry of the Same Rehydrated Brains Reveals Ischemic Brain Injury and Early Microvascular Remodeling
Authors: Mohamud Yusuf Ayan , Hagemann Nina , Schulten Sarah , Rausch Olessja , Wagner Kristina , Hussner Tanja , Qi Yachao , Totzeck Matthias , Kleinschnitz Christoph , Squire Anthony , Gunzer Matthias , Hermann Dirk M.
Published: January 2021

Until recently, the visualization of cerebral microvessels was hampered by the fact that only short segments of vessels could be evaluated in brain sections by histochemistry. These limitations have been overcome by light sheet microscopy, which allows the 3D analysis of microvasculature in cleared brains. A major limitation of light sheet microscopy is that antibodies do not sufficiently penetrate cleared brains. We herein describe a technique of reverse clearing and rehydration, which after microvascular network analysis allows brain sectioning and immunohistochemistry employing a broad set of antibodies. Performing light sheet microscopy on brains of mice exposed to intraluminal middle cerebral artery occlusion (MCAO), we show that in the early phase of microvascular remodeling branching point density was markedly reduced, more strongly than microvascular length. Brain infarcts in light sheet microscopy were sharply demarcated by their autofluorescence signal, closely corresponding to brain infarcts revealed by Nissl staining. Neuronal survival, leukocyte infiltration, and astrocytic reactivity could be evaluated by immunohistochemistry in rehydrated brains, as shown in direct comparisons with non-cleared brains. Immunohistochemistry revealed microthrombi in ischemic microvessels that were likely responsible for the marked branching point loss. The balance between microvascular thrombosis and remodeling warrants further studies at later time-points after stroke.
On the Validity of Neural Mass Models
Authors: Deschle Nicolás , Ignacio Gossn Juan , Tewarie Prejaas , Schelter Björn , Daffertshofer Andreas
Published: January 2021

Modeling the dynamics of neural masses is a common approach in the study of neural populations. Various models have been proven useful to describe a plenitude of empirical observations including self-sustained local oscillations and patterns of distant synchronization. We discuss the extent to which mass models really resemble the mean dynamics of a neural population. In particular, we question the validity of neural mass models if the population under study comprises a mixture of excitatory and inhibitory neurons that are densely (inter-)connected. Starting from a network of noisy leaky integrate-and-fire neurons, we formulated two different population dynamics that both fall into the category of seminal Freeman neural mass models. The derivations contained several mean-field assumptions and time scale separation(s) between membrane and synapse dynamics. Our comparison of these neural mass models with the averaged dynamics of the population reveals bounds in the fraction of excitatory/inhibitory neuron as well as overall network degree for a mass model to provide adequate estimates. For substantial parameter ranges, our models fail to mimic the neural network's dynamics proper, be that in de-synchronized or in (high-frequency) synchronized states. Only around the onset of low-frequency synchronization our models provide proper estimates of the mean potential dynamics. While this shows their potential for, e.g., studying resting state dynamics obtained by encephalography with focus on the transition region, we must accept that predicting the more general dynamic outcome of a neural network via its mass dynamics requires great care.
Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold
Authors: Tanaka Shota , Gomez-Tames Jose , Wasaka Toshiaki , Inui Koji , Ueno Shoogo , Hirata Akimasa
Published: January 2021

Electrical stimulation of small fibres is gaining attention in the diagnosis of peripheral neuropathies, such as diabetes mellitus, and pain research. However, it is still challenging to characterise the electrical characteristics of axons in small fibres (Aδ and C fibres). In particular, in vitro measurement for human Aδ-fibre is difficult due to the presence of myelin and ethical reason. In this study, we investigate the in vivo electrical characteristics of the human Aδ-fibre to derive strength–duration (S–D) curves from the measurement. The Aδ-fibres are stimulated using coaxial planar electrodes with intraepidermal needle tip. For human volunteer experiments, the S–D curve of Aδ-fibre is obtained in terms of injected electrical current. With the computational analysis, the standard deviation of the S–D curve is mostly attributed to the thickness of the stratum corneum and depth of the needle tip, in addition to the fibre thickness. Then, we derive electrical parameters of the axon in the Aδ-fibre based on a conventional fibre model. The parameters derived here would be important in exploring the optimal stimulation condition of Aδ-fibres.
Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma
Authors: Jeschke Marcus , Happel Max F. K. , Tziridis Konstantin , Krauss Patrick , Schilling Achim , Schulze Holger , Ohl Frank W.
Published: January 2021

Harmful environmental sounds are a prevailing source of chronic hearing impairments, including noise induced hearing loss, hyperacusis, or tinnitus. How these symptoms are related to pathophysiological damage to the sensory receptor epithelia and its effects along the auditory pathway, have been documented in numerous studies. An open question concerns the temporal evolution of maladaptive changes after damage and their manifestation in the balance of thalamocortical and corticocortical input to the auditory cortex (ACx). To address these issues, we investigated the loci of plastic reorganizations across the tonotopic axis of the auditory cortex of male Mongolian gerbils (Meriones unguiculatus) acutely after a sound trauma and after several weeks. We used a residual current-source density analysis to dissociate adaptations of intracolumnar input and horizontally relayed corticocortical input to synaptic populations across cortical layers in ACx. A pure tone-based sound trauma caused acute changes of subcortical inputs and corticocortical inputs at all tonotopic regions, particularly showing a broad reduction of tone-evoked inputs at tonotopic regions around the trauma frequency. At other cortical sites, the overall columnar activity acutely decreased, while relative contributions of lateral corticocortical inputs increased. After 4–6 weeks, cortical activity in response to the altered sensory inputs showed a general increase of local thalamocortical input reaching levels higher than before the trauma. Hence, our results suggest a detailed mechanism for overcompensation of altered frequency input in the auditory cortex that relies on a changing balance of thalamocortical and intracortical input and along the frequency gradient of the cortical tonotopic map.
Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells
Authors: Liu Xin , Qu Le , Zhang Na , Yu Xiaoqi , Xiao Zhixin , Song Limei , Xie Junxia , Xu Huamin
Published: January 2021

Nedd4 family interacting protein 1 (Ndfip1) is an adaptor of Nedd4-family ubiquitin ligases. Experimental results showed that Ndfip1 had a potential neuroprotective effect in neurology diseases. However, the neuroprotective effect and the underlying mechanisms of Ndfip1 in Parkinson's disease (PD) have not yet been fully elucidated. Therefore, in this study, we explored the neuroprotective effect of Ndfip1 against mitochondrial complex I inhibitor rotenone in a human dopaminergic neuroblastoma SH-SY5Y cell line and further elucidated its possible underlying mechanisms. Our results showed that rotenone could induce the up-regulation of α-synuclein (α-syn) in both mRNA and protein levels. The expression of Ndfip1 decreased at 24 h after rotenone treatment. Further study showed that high expression of Ndfip1 could protect SH-SY5Y cells against rotenone-induced neurotoxicity and antagonize the rotenone-induced increase in α-syn protein levels. In addition, high expression of Ndfip1 inhibited rotenone-induced increase in the protein levels of caspase-3 and decrease in tyrosine hydroxylase (TH). Further study showed that Ndfip1 did not affect the protein expression of iron regulatory protein 1 (IRP1), transferrin receptor 1 (TfR1), while antagonized the increase in protein levels of P62 and ferritin L caused by rotenone. Our findings provide specific identification of Ndfip1 proteins to inhibit the increase of α-syn in rotenone-induced SH-SY5Y cells. Ndfip1 might be a new theoretical drug target for the prevention and treatment of PD.
The Fib-PNI-MLR Score, an Integrative Model of Coagulation Cascades, Nutrition Status, and Systemic Inflammatory Response, Predicts Urological Outcomes After Surgery in Patients With Non-Metastatic Renal Cell Carcinoma
Authors: Gao Xiaomin , Pan Yue , Zhou Lina , Li Yeping , Lin Binwei , Zheng Yangqin
Published: January 2021

Cancer-associated inflammation, activation of coagulation cascades, and malnutrition are closely related to the prognosis of patients with malignancy, including renal cell carcinoma (RCC). This study aimed to investigate the prognostic value of a combination of preoperative plasma fibrinogen, prognostic nutritional index, and monocyte-to-lymphocyte ratio (Fib-PNI-MLR) in patients with non-metastatic RCC undergoing nephrectomy. We retrospectively collected medical data from 829 of the 1,019 cases of RCC. The optimal cutoff values of fibrinogen (≥3.54 vs. <3.54, mg/dl), PNI (<47.03 vs. ≥47.03), and MLR (≥0.29 vs. <0.29) were defined using receiver operating characteristic (ROC) analysis and the Fib-PNI-MLR score (range, 0–3) was determined as the sum of points (0 or 1) assigned to each indicator. As a result, Fib-PNI-MLR was an independent risk factor for overall survival (OS), cancer-specific survival (CSS), and metastatic-free survival (MFS) (all P < 0.05). The concordance-index and area under the curve (AUC) were larger for the Fib-PNI-MLR score than that for other clinical parameters. Subgroup analysis (Fuhrman grade G1+G2 and Fuhrman grade G3+G4; pathologic T1, T2, and T3–4 stage) revealed the significant association of a higher Fib-PNI-MLR score with poor urological outcomes (all P < 0.05). Data indicated that patients with higher Fib-PNI-MLR might benefit from partial nephrectomy. The Fib-PNI-MLR score might serve as a promising prognostic factor in patients with non-metastatic RCC.
Use of Audiobooks as an Environmental Distractor to Decrease State Anxiety in Children Waiting in the Pediatric Emergency Department: A Pilot and Feasibility Study
Authors: Stein Duker Leah I. , Schmidt Anita R. , Pham Phung K. , Ringold Sofronia M. , Nager Alan L.
Published: January 2021

Objectives: Anxiety and anticipatory stressors are commonly experienced by children visiting the Pediatric Emergency Department (PED), but little research exists that addresses the efficacy of interventions to decrease this stress. This one-sample pretest-postest pilot study gathered preliminary data on the feasibility and effectiveness of utilizing audiobooks to reduce fear and state anxiety in children in the PED.

Methods: Participants were 131 children in kindergarten through 8th grade (M = 9.4 years, 54% female), triaged urgent or emergent, presenting to the PED. Participants self-reported fear (Children's Fear Scale) and state anxiety (modified State-Trait Anxiety Inventory for Children; mSTAIC) before and after listening to an age-appropriate audiobook (two options). Data regarding patient experience were also collected. Paired samples t-test was used to examine pre–post intervention changes in fear and state anxiety.

Results: Significant, albeit small, improvements in fear and the mSTAIC states of nervous, calm, happy, and relaxed were found after use of the audiobook (Cohen's dz = 0.22–0.35). Small, yet significant correlations were found between child age/grade level and improvements in fear and in the mSTAIC states of scared and relaxed, suggesting that the audiobook was more beneficial for older participants. Over 60% of participants liked the audiobook content “a lot” as well as enjoyed listening to the audiobook “a lot.” Without prompting, 15% of participants requested to listen to an additional audiobook.

Conclusions: Listening to an audiobook is feasible and could be effective in decreasing fear and state anxiety for children during a waiting period in the PED. The technology is low-cost, simple, and portable. The results of this study should be interpreted with prudence due to the lack of a control group and results that, although significant, were modest based on effect size conventions; future studies should explore the impact of audiobooks on patient stress with an expanded sample size and control group.