bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Public Interest in Telkomsel Cards Using the Decision Tree Method
Authors: Cantika Putri Talia , Yanris Gomal Juni , Hasibuan Mila Nirmala Sari
Published: May 2023

SIM card (Subscriber Identification Module) card is a physical electronic device that is the integrated circuit of the internet. Sim cards are used by the public as a place to store quotas for internet, phone calls and SMS. There are many types of SIM cards that are used by the public, such as Telkomsel cards, XL cards, Exis cards and Smartfren cards. There are some people who are interested and use Telkomsel cards, because the network is good. But there are some people who don't use Telkomsel cards, because the quota price is quite expensive. Therefore, the Penlus will make research about people's interest in Telkomsel cards. This study aims to determine the amount of public interest in the Telkomsel card. To conduct this research, the authors used 42 community data which would be classified using the decision tree method. The data used by the author was obtained by distributing a questionnaire to the public. After classifying using the decision tree method, the result is that the people who are interested in the Telkomsel card are 33 people who are interested in the Telkomsel card (for the representation results it is 78.5%) and the results obtained are that the people who are not interested in the Telkomsel card are 9 people (for its representation results of 21.4%). From the results of the study, many people are interested in Telkomsel cards, even though the internet, call and SMS quota prices are quite expensive.
Implementação de aulas fisicamente ativas e pausas ativas: Um relato de experiência do Projeto Erguer/Aracaju
Authors: Silva Marcel Belitardo da , Melo João Carlos do Nascimento , Silva Ellen Caroline Mendes da , Souza Beatriz Noia , Tejada Herrera Hector Julian , Silva Danilo Rodrigues Pereira da
Published: May 2023

O projeto Erguer/Aracaju tem como proposta acompanhar a evolução cognitiva e do desempenho acadêmico, bem como, a diminuição do comportamento sedentário dos alunos através do movimento nas aulas. Este relato de experiência objetiva analisar a intervenção e implementação do Projeto Erguer/Aracaju a respeito das aulas fisicamente ativas e pausas ativas. Atualmente a pesquisa acontece em seis escolas da rede municipal de Aracaju-SE. As escolas estão divididas em grupos de intervenção (aulas fisicamente ativas e pausas ativas) e grupo controle. A amostra é composta por 181 crianças do primeiro ano do ensino fundamental do ano letivo de 2022. Este relato reflete sobre as informações obtidas empiricamente a partir da coleta de dados, das reuniões semanais da equipe de pesquisa, dos diários de campo, filmagens das intervenções e capacitação dos professores. O conteúdo do projeto foi inserido na organização pedagógica das escolas durante o ano letivo, e os resultados indicam que as ações do projeto Erguer/Aracaju foram positivas e precisam se intensificar para que essa nova perspectiva se mantenha fortalecida.
HISTOLOGICAL AND HISTOCHEMICAL EVALUATION OF NORMOTENSIVE AND PREECLAMPTIC PLACENTAS
Authors: ERDOGAN Gamze , NERGİZ Yusuf , AĞAÇAYAK Elif
Published: May 2023

The placenta plays a role in the pathophysiology of preeclampsia.
Preeclampsia is more common in multifetal pregnancies than singleton
pregnancies. In this study, we aimed to investigate the histopathology of
normotensive and preeclamptic placentas and the localization of alkaline
phosphatase activity. In our study, 10 normotensive and 10 preeclamptic,
totally 20 placentas were obtained.Paraffin sections were stained with
Hematoxylin-Eosin, Masson trichrome and PAS for histopathological
examination.Remaining sections were then stained via Gomori’s method and
micrographed under light microscope. Sections of the control group observed
normal histologically structure.The 
alkaline phosphatase reaction was evident in the inner and outer
membranes of the syncytiotrophoblasts. There was a significant increase in the
number of syncytial knots, terminal villi and syncytial bridges in the
preeclamptic placenta sections. Marked thickening of the trophoblast basal
membranes were observed. Alkaline phosphatase reaction in preeclampsia
group: The localization of alkaline phosphatase in the inner and outer
membranes of the syncytiotrophoblasts was reduced. In placentas of preeclampsia
group, a significant increase in syncytial knot, syncytial bridge were
observed. The level of alkaline phosphatase enzyme in preeclamptic placentas
was found to be lower compared to normotensive placenta.
HISTOPATHOLOGICAL CHANGES OF THE UMBILICAL CORD IN COMPLİCATED PREGNANCIES
Authors: KAYA Seval , NERGİZ Yusuf , TURGUT A. Kadir
Published: May 2023

Preeclampsia, hellp
syndrome and gestational diabetes are quite common complication in pregnancy. In this study,ıt is aimed to compare the thickness  of
 basal  lamina
and vascular structure of umbilical cord. by
comparing preeclampsia,
hellp syndrome, gestational diabetes and normal pregnant women.
In
the study, sanples were taken from postpartium
umbilical cords of
normal pregnant
women, preeclampsia, gestational diabetes and pregnant women diagnosed
with
hellp syndrome. Umblical cord samples taken during maternity, followed by routine paraffin through fixing 10% neutral formalin. In this performed as totally sixty
facts through
taking fifteen
umbilical cords from each of four groups, Hematoxyline-eosin, Masson trichrom, periodic
acid Schiff,
and toluidine
blue stain were applied
on to the serial histological sections obtained from paraffin blocks. The obtained slides
were evaluated
with
Zeiss Imager 2 Microscope by taking micrographs. Morphometric measurements were statistically analyzed with SPSS software. In cases of gestational diabetes due to increased collagen production, thickening and excessive narrowing of the lumen and differentiation of Wharton jelly were observed in the umbilical artery. Differentiations are observed in the vacuolization of smooth muscle cells and muscle fibers that make up the media while camber and damage are observed in
endothelial. The most significant structural changes of preeclamptic placentas are obtained
as
the thickening
and
the endothelial injury. In the umbilical cord artery medial layer, due to
the
growth of collagen fiber. In HELLP
cases due to the increase in media diffuse edema
between muscle fibers and in collagen,
the
thickening of umbilical
artery wall and the
narrowing of luminal are seen
as extremely significant. Another striking symptom
with HELLP cases is the observing of
intramuscular hemorrhages in the umbilical artery wall as an
unattained case in preeclampsia and gestational diabetes. In most of the cases, differentiation in Wharton jelly, metaplastic changes in the amniotic epithelium and thickening
of the basal
lamina are observed.
Determination of Macro, Micro Element and Heavy Metal Contents of Astragalus Taxa Collected from Nature
Authors: ÇAÇAN Erdal , KILIÇ Ömer , KÖKTEN Kağan
Published: May 2023

The aim of the research is to determine the macro (Ca, Mg, P and K), micro (Fe, Mn, Cu, Zn and Be) element and heavy metal (Al, Cr, Ni, Se and Cd) contents of some Astragalus taxa collected from nature. Nine Astragalus taxa (Astragalus gummifer, A. compactus, A. lineatus var. longidens, A. aureus, A. onobrychis, A. declinatus, A. lineatus var. lineatus, A. oocephalus subsp. stachyophorus, A. inereus) collected from the natural areas of Bingöl province were used as the plant material of the research. Astragalus taxa were collected from the central villages of Bingöl province in June 2018, during the flowering period of the plants. Macro, micro element and heavy metal contents of the collected and dried plant samples were determined with the help of NIRS (Near Infrared Spectroscopy) and ICP-MS (Inductively Coupled Plasma - Mass Spectometry) devices. As a result of the analysis, the average Ca content of Astragalus taxa was determined as % 1.63, Mg content % 0.36, P content % 0.27, K content % 1.49, Fe content 2436 mg kg-1, Mn content 153.7 mg kg-1, Cu content 84.5 mg kg-1, Zn content 14.08 mg kg-1, Be content 0.10 mg kg-1, Al content 2535 mg kg-1, Cr content 7.67 mg kg-1, Ni content 9.99 mg kg-1 and Se content 2.19 mg kg-1. In general, the highest Ca, Mg, Fe, Mn, Al, Cr and Ni contents were determined in A. declinatus, the highest P and K contents were determined in A. oocephalus subsp. stachyophorus, the highest Cu content was determined in A. cinearus, the highest Zn content was determined in A. lineatus var. longidens, the highest content Be was determined in A. gummifer and the highest Se content was determined in A. compactus. Cd content could not be detected in any Astragalus taxa. As a result of the study, it was concluded that Astragalus taxa, which are abundant in the natural flora of our country, can be used as a source of roughage in animal nutrition and can meet the macro and micro element needs of animals.
Effects of Adding Anti-saline and Humic Acid Foliar Spraying on Yield Parameters of Cauliflower (Brassica oleracea var. Botrytis)
Authors: HASSAN Waleed , BADER Basem
Published: May 2023

Spraying humic acid on a growing plant cauliflower enhances chlorophyll and carotene levels in the leaves; its crucial role in protecting plants from salt stress, water stress, and heavy metals, and its many other advantages in saline soils. The research study was carried out in one of the agricultural fields in the Muqdadiyah area, Haruniyah area, 21km, using a randomized complete block design (RCBD) and a normal factorial experiment during the agricultural season 2019-2020. It was located 40 kilometers North-East of Diyala governorate, Baquba district. This study aimed to determine how adding anti-saline and spraying humic acid affects the yield parameters of Nahar cauliflower. The results demonstrated that the addition of anti-saline when treated with N2 was superior in the majority of the studied traits, including: (head weight, head diameter, percentage of dry matter in the heads, total yield, and total plant weight without the heads). Sequentially, the results demonstrated (4349 g, 26.39 mm, 15.79 %, 13.39 mcg ha-1, 1.971 kg plant-1) superiority over the control treatment. The majority of the analyzed parameters, including (head weight, head diameter, percentage of dry matter in heads, total yield, and total plant weight without heads) (3584 g, 26.52 mm, 16.80 percent, 15.15 tons H-1, 2.182 kg plant-1), were superior to the control treatment (3584 g, 26.52 mm, 16.80 percent, 15.15 tons H-1, 2.182 kg plant-1). The N2H2 treatment was found to be higher in most of the analyzed parameters, including (head weight, head diameter, percentage of dry matter in the heads, total yield, and total plant weight without the heads), which were (4684 g, 29.80 mm, 19.33 percent, 15.47 tons h-1, 3.224 kg plant-1) respectively compared to the control.
Estimation of Erosion and Sediment using Gavrilović Method in Krueng Jreu Sub-basin, Aceh Province, Indonesia
Authors: DEVİANTİ Devianti , RAMLI Ichwana , ARYANI Intan , SATRIO Purwana , SARTİKA THAMREN2 Dewi
Published: May 2023

Erosion and sediment in a basin can be estimated by calculating and forecasting using various methods. This study aims to assess erosion and sedimentation in the Krueng Jreu sub-basin in the province of Aceh, Indonesia, using the Gavrilović method. This research was carried out by analyzing secondary data for the last ten years, from 2012 to 2021. Data include geology, slope, land use, and river channel networks. The observed parameters include the coefficient of intensity of erosion, temperature coefficient, and sedimentation coefficient, which are used to analyze the erosion volume, spatial sediment rate, and total sediment rate in the Krueng Jreu sub-basin area. The results of calculations using the Gavrilović method show that four main parameters of the biophysical characteristics of the sub-basin, including (1) sensitivity of soil and local geological conditions to erosion, (2) land use, (3) erosion type, and (4) slope of land, have been shown to affect the occurrence of erosion and annual sediment rates. Geological conditions and land use provide a high level of sensitivity to the results of the coefficient of intensity of erosion. Temperature and rainfall are directly proportional to the annual erosion volume and the spatial sediment rate. The lowest yearly erosion volume and spatial sediment rate in 2019 were 64965.41 m3km-2year-1 and 58206.18 m3km-2year-1. Meanwhile, the highest annual erosion volume and spatial sediment rate will occur in 2021, 101500.71 m3km-2year-1 and 90940.21 m3km-2year-1. Fluctuations in the annual volume of erosion are caused by rainfall, affecting the spatial sediment rate and the total sediment rate.
PENGEMBANGAN APLIKASI PEMBELAJARAN BAHASA ARAB UNTUK PEMULA BERBASIS WEB
Authors: Febriana Dina , Iswari Lizda
Published: May 2023

Pembelajaran bahasa arab di Indonesia masih memiliki tantangan dalam metode penyampaiannya. Hal ini dapat dilihat pada media pembelajaran Bahasa Arab sebagian besar masih terpaku pada buku dan metode penyampaian tradisional berupa ceramah satu arah. Oleh karena itu diperlukan media pembelajaran yang dapat meningkatkan motivasi pelajar untuk mempelajari bahasa arab. Dalam penelitian ini dikembangkan sebuah aplikasi pembelajaran bahasa arab untuk pemula berbasis web dengan metode penelitian research and development. Metode penelitian tersebut dilaksanakan melalui studi literatur dan studi lapangan untuk dapat menemukan inti permasalahan sehingga dapat merancang kebutuhan aplikasi sebagai solusi efektif. Tujuan dari penelitian ini adalah dibangunnya sebuah aplikasi pembelajaran bahasa arab untuk pemula berbasis web dengan materi berupa pengenalan huruf, pengenalan angka, kosakata, dan penyusunan kalimat. Materi akan disajikan dalam bentuk teks, audio, dan gambar sehingga dapat meningkatkan ketertarikan pelajar dalam mempelajari dan memahami dasar bahasa arab. Selain itu, aplikasi dikembangkan berbasis web sehingga pengguna dapat mengakses aplikasi menggunakan berbagai platform. Setelah aplikasi berhasil dikembangkan, kemudian diberikan kepada sejumlah responden untuk mengetahui tingkat kelayakan sistem. Hasil pengujian menggunakan metode pengujian system usability scale dan menghasilkan predikat “Good” sehingga masih layak untuk digunakan para pelajar.

Kata kunci-aplikasi berbasis web, bahasa arab, media pembelajaran
Navigating between the state and the streets
Authors:   , Brummel Lars
Published: May 2023

For public sector organisations, accountability has become a navigation act. They are not
only accountable to ministries and the government (“the state”), but also have to deal
with accountability demands from societal stakeholders (“the streets”). Various politicians
and academics have argued in favour of social accountability: forms of accountability
directed to citizens, clients, users, and other stakeholders. But when and why does social
accountability matter in executive governance?

This dissertation sketches an empirically fine-grained picture of the many faces of
social accountability. It is based on multi-methodological research, including surveys,
experiments, focus groups, and qualitative interviews. Although social accountability is
not as prominent as political accountability, public sector organisations consider social
accountability to be important. This is particularly the case when they are confronted
with social media pressures. The dissertation further shows that social accountability is
a limited control instrument. Rather, social accountability arrangements, such as client
councils and stakeholder panels, often serve practical and strategic ends for public sector
organisations. Particularly, social accountability can strengthen citizens' perceptions
of the legitimacy of organisational decisions. This dissertation calls for a nuanced
understanding of the actual impact of social accountability. While accountability to the
state is necessary for political and democratic control, accountability to the streets is most
relevant for effective public policy implementation and the reputation and legitimacy of
public sector organisations.
Urban Growth, Resident Welfare, and Housing Markets
Authors:   , Cai Yuanyuan
Published: May 2023

Cities have become the principal platform of economic growth and residents’ settlements. The importance of urban growth in residents’ quality of life is increasingly evident, because of the intimate interaction between urban characteristics and human activities. Cities shape urban residents’ welfare, bringing benefits and disadvantages as well. The complex way in which urban growth and residents’ activities interact makes it difficult to figure out which kinds of urban features are positively or instead negatively associated with residents’ quality of life. This puzzle makes it harder to clarify whether cities can provide enough net welfare to their residents. Thus, there is a major challenge to understand and evaluate how and to what extent urban growth shapes the welfare of urban residents.
The link between cities and welfare has been hotly debated, yet we still have a limited grasp of how urban growth may impact residents’ welfare. Most studies concentrate on a certain dimension of urban welfare and a specific geographical scale. However, the interaction between urban growth and resident welfare may touch upon multiple dimensions of welfare coincidently, and it may take different forms across geographical scales.
This thesis focuses on urban growth in China, against the background of a newly industrializing and developing country. Through the housing market dynamic, its central claim is to explore the tensions between the positive and negative effects of urban growth on resident welfare at multiple dimensions (economic, social, environmental, and policy) and scales (intra-city, inter-city, and countrywide) from a spatial inequality perspective.
MOVING FORWARD
Authors:   , Toonders Suze Adriana Johanna
Published: May 2023

Most people at times experience physical symptoms such as pain, fatigue or dizziness.
Surveys show that approximately 90% of the Dutch general population experienced
at least one physical symptom in the past two weeks. While in most cases symptoms
disappear spontaneously, in certain cases symptoms persist for a few weeks or
even months without having an identifiable underlying explanation. Such Medically
Unexplained Physical Symptoms (MUPS) can have a high impact on quality of life and
daily functioning, impairing social, physical and psychological functioning. Whether
people visit their general practitioner with concerns about these symptoms is strongly
related to the impact on daily life and ideas about these symptoms. Developing MUPS
is more common when patients are concerned and develop negative catastrophizing
beliefs. MUPS can be regarded on a continuum with a spectrum ranging from mild to
moderate and then persisting or chronic MUPS. This dissertation focused on patients
with moderate MUPS and preventing chronicity in this patient group. The moderate
MUPS population has a high prevalence in primary care, yet little research has been
done on preventing chronicity. Furthermore, there is not yet an appropriate treatment
to reduce the burden for these patients, straining healthcare professionals and incurring
high healthcare and societal costs.

Given the ambitions to provide the right care, for the right patient, in the right place, at the
right time, we find a combination of early identification of patients with moderate MUPS
and a preventive intervention integrating eHealth (blended care) a move forward. What
lies ahead is to tailor such interventions, rather than offer a one-size-fits-all treatment.
Increasing insights into self-management skills and movement behavior during
treatment can aid the tailoring of interventions, as can early identification of patients’
needs, motivation, and the requested use of eHealth. As this way of treatment differs
from usual care, healthcare professionals should be coached more on their changing role
from treating patients to coaching patients.
Intracranial aneurysms
Authors:   , Mensing Liselore Adelinde
Published: May 2023

An intracranial aneurysm is an acquired dilatation of the vessel wall of a cerebral artery.
Most remain asymptomatic, but some can rupture, causing an aneurysmal subarachnoid haemorrhage (aSAH). This is a devastating subset of stroke with a poor outcome. Screening for unruptured intracranial aneurysms can prevent future aSAH by early detection and preventive treatment of identified aneurysms. Screening should ideally only be done in persons in whom a high lifetime risk of aSAH outweighs the risk of complications of preventive treatment and the potential negative effects of screening on quality of life. Screening has been shown effective for persons with a positive family history for aSAH. However, this group constitutes only a minority of all patients with aSAH. Therefore, more persons with an increased risk of aSAH should be identified. Also, more information on predictors of aneurysm rupture is needed to further improve prevention of aSAH.

This thesis presents the yield of screening for intracranial aneurysms in two groups of persons with a potentially increased lifetime risk of aSAH. Also, the course and predictors of the effect of screening on quality of life are described. Last, the rupture risk of familial intracranial aneurysms is determined, and patient and aneurysm related characteristics potentially contributing to this risk are studied. This information can be used to improve counselling on screening for intracranial aneurysms. In addition, our findings can contribute to the reduction of the number of life years in good quality being lost through aSAH, by improving screening for intracranial aneurysms and prediction of aSAH.
Aggression in School Students: An Intervention Focused Approach
Authors: SY Bhave , S Manchanda , K Nahata , A Raghuvanshi , S Joshi , A Sovani
Published: May 2023

Introduction: The present research was conducted as a part of a series of multicentric youth studies to study aggression in school children followed by intervention programs for the school to prevent violence. Aggression in young children is an important precursor to how they perceive and process a variety of experiences through the course of their lives. It influences and underlines their emotional, behavioral, social, and psychological wellbeing. Identifying the prevalence and strength of beliefs and attitudes towards aggression among young, school-going students’ is thus fundamental, and would help in designing targeted interventions for those at-risk. Sample: In the present cross-sectional study of 988 students, a total of 602 boys and 386 girls of grades 5 th to 12 th in a private, co-ed, English medium school in Delhi were administered a self-rated questionnaire adapted from CDC Compendium of tools measuring aggression. Results: Greater rates of aggressive beliefs (p=0.018) and violent attitudes (p ≤ 0.001) are seen in higher grades (VIII-X std. students) as compared to younger batches of V and VI graders, who show higher rates of aggressive behaviors comparatively (p ≤ 0.001). There was a statistically significant difference in girls and boys, where boys in younger grades (V-VI std.) show more aggressive behaviors, whereas girls show increased aggressive behaviors by the IX std. (p ≤ 0.001). Regression analysis showed that aggressive beliefs are a strong predictor of aggressive behavior. Correlation with age showed the prevention should begin at V Std. Conclusions: The roots of aggressiveness are present early in school years, and strengthen as students’ progress through secondary grades. Early, targeted interventions are thus essential in helping children and adolescents attenuate and channelize their impulses in a healthier mode of expression.
Selenyum Dioksit ve Paklitaksel Kombinasyonunun MDA-MB-231 Meme Kanseri Hücre Hattı Üzerine Etkisinin Değerlendirilmesi
Authors: BULUT Seda , ÖNDER Gözde Özge , YAY Arzu
Published: May 2023

Amaç: Bu çalışmanın amacı, bitkisel kökenli bileşik olan selenyum dioksit (SEL) ile kemoterapötik ilaç olan paklitaksel’in (PTX) kombine uygulamasının MDA-MB-231 meme kanseri hücre hattı üzerine etkisinin belirlenmesidir.

Gereç ve Yöntemler: Çalışmamızda öncelikle SEL’in yarı maksimal inhibitör konsantrasyonunun belirlenmesi amacıyla MTT testi yapıldı. Deney grupları SEL1, SEL2, SEL3, PTX, SEL1+PTX, SEL2+PTX ve SEL3+PTX şeklinde oluşturulduktan sonra apoptoz TUNEL metodu, NF-kB ekspresyonu immunofloresan boyama metodu ile hücre canlılığı ise MTT analizi ile gösterildi.

Bulgular: SEL’in meme kanseri hücrelerinde hücre canlılığını azalttığı gösterildi. SEL1, SEL2, SEL3, PTX gruplarında kontrole göre apoptozun arttığı görüldü (p0,999, p>0,999, p=0,725).

Sonuç: Mevcut çalışmada MDA-MB-231 meme kanseri hücre dizisinde SEL ve PTX’in antagonistik etkiye sahip oldukları belirlenmiştir.
Sociodemographic and Clinical Characteristics of Children and Adolescents Applying to the Child Psychiatry Outpatient Clinic in Düzce
Authors: ÖZ Büşra , KIVRAK Asil Can
Published: May 2023

Aim: In our study, it was aimed to examine the sociodemographic characteristics, symptoms, psychiatric disorders of children and adolescents who applied for the first time to a university hospital child and adolescent psychiatry outpatient clinic.

Material and Methods: The files of 724 children and adolescents who applied to our outpatient clinic were reviewed retrospectively. 211 patients evaluated for the first time in our outpatient clinic were included in the study. Sociodemographic characteristics, first admission complaints, psychiatric diagnoses and treatments of the patients were evaluated.

Results: The mean age of the patients included in the study were 9.90±4.07 years. It was determined that 117 (55.5%) of the patients had a previous psychiatric diagnosis. The most common complaints at presentation were attention deficit/hyperactivity (45%), irritability (20.4%), and fear-anxiety (15.2%). It was determined that 191 (90.5%) of the patients had at least one psychiatric disorders and 49 (23.2%) had at least two psychiatric disorders. The most common psychiatric disorders were ADHD (54.9%), AD (20.4%), BD (10.4%) and MDD (8.3%). It was determined that 46% of the patients received psychiatric treatment, and methylphenidate (62.9%) was the most common use.

Conclusion: In our study, the most common complaint of the patients was attention deficit/hyperactivity, and the most common diagnosis was ADHD. Our results are similar to other studies. The presence of comorbidity increases the severity of the disorders and causes serious deterioration in psychosocial functionality. Diagnoses between genders and comorbidities should be carefully evaluated in patients applying to child and adolescent psychiatry.
The Frequency of Pancreatic Enzyme Elevations and Effect on Disease Severity in COVID-19
Authors: ALKAN Sevil , GÖKÇE Oruç Numan , ÇİNPOLAT Havva Yasemin
Published: May 2023

Aim: In this study, we aimed to evaluate the frequency of pancreatic enzyme elevations in COVID-19-infected patients and to examine the effect on disease severity.

Material and Methods: A total of 1249 patients who hospitalized with COVID-19 infection were included. The frequency of pancreatic enzyme elevations and the effect on disease severity in patients infected with COVID-19 were investigated.

Results: The pancreatic enzyme elevations (amylase/lipase or both) were detected in 32 of 1249 patients (incidence 2.96%). 32 cases with a mean age of 64.97±5.63 years were included in this study. 30 (93.75%) of the cases were men’s gender. 31 (96.87%) of them had elevated amylase levels, 26 (81.25%) had elevated lipase levels and 25 (78.12%) of them had elevated both amylase and lipase levels. Only 10 (31.25%) of them tested radiological for acute pancreatitis (AP) and there was no radiological finding compatible with AP in any of the limited numbers of abdominal computerized tomography scans performed. 18 (56.25%) of the patients were transferred to the intensive care unit due to clinical worsening and mortality developed in 13 (40.62%) patients. The mean age of the deceased cases was 66.4±6.6 years and there was no statistically significant difference between deceased and survived COVID-19 patients (>0.05).

Conclusion: The median lymphocyte count was lower, and the median AST, ALT, and lipase levels were higher in the deceased group. Perhaps close clinical follow-up of patients with pathological findings in these values and radiological imaging, if necessary, may be beneficial in the method of the disease.

Keywords: COVID-19; disease severity; pancreatic enzyme elevations.
Anticancer Activity of Endemic Phlomis Extracts in HCT116 Human Colon Cancer Cells
Authors: KURMAN Yener , PASİN Ozge
Published: May 2023

Aim: Previous studies have reported that Phlomis russeliana shows cytotoxic effects against several cancer cell lines; however, its anti cancer activity on HCT-116 cancer cells has not yet been investigated. Therefore, the present study is designed to explore anti-cancer properties of Phlomis russeliana against HCT-116 human colon cancer cell line and HUVEC normal cell line.

Material and Methods: HCT-116 cells and HUVECs treated with different concentrations of Phlomis russeliana (2, 4, 6, 8 and 10 mg/ml) and cell viability evaluated by the MTT assay. Anti-migratory and anti-colonigenic effects of Phlomis russeliana were assessed with wound healing and colony formation assays respectively. Quantitative determination of total antioxidant status (TAS), total oxidant status (TOS) and caspase-3 activation were performed with colorimetric Elisa kits.

Results: Phlomis russeliana significantly decreased cell viability of HCT-116 cells in a concentration dependent and showed weaker toxicity against normal HUVECs. Pholomis russeliana significantly inhibited migration and colony formation potential of HCT-116 cells. A significant increase in caspase-3 activation was observed after treatment with Phlomis russeliana. Phlomis russeliana did not significantly affect the TAS and TOS level in HCT-116 cells.

Conclusion: These results revealed that Phlomis russeliana showed anti-cancer activity in human colon cancer cells, through the suppression of colony formation, inhibition of migration and induction of caspase-3 activation. Phlomis russeliana, could be a promising source for the development of new anti-cancer agents against cancer.
Batı Ege Bölgesinde α-Talasemi Genotipleri ve α-Talasemi Genotip Frekansı
Authors: BARIŞ Savaş , YAVAŞ Cüneyd , BALASAR Özgür , GÖRDÜ Zülfükar , DOĞAN Mustafa , ERÖZ Recep
Published: May 2023

Amaç: Yaygın görülen bir tek gen hastalığı olan Alfa talasemi, α-globin zincirinin kusurlu sentezi ile ortaya çıkar. Globin genlerindeki bozukluklara bağlı olarak çok geniş bir klinik spektruma yayılan bu hastalıkta çok sayıda belirlenmemiş taşıyıcı olduğu düşünülmektedir. Klinik semptomu olmayan sessiz taşıyıcılardan, rahim içinde ölüme yol açan şiddetli anemi ile kendini gösteren, çok değişken bulgulara sahip genetik bir hastalıktır. Bu çalışmada bu amaçla alfa globin gen mutasyonu sıklığının ve tiplerinin bulunması ve varyasyon saptanan bireylerdeki fenotipik etkiyi görmek amaçlandı.

Gereç ve Yöntemler: HBA1 ve HBA2 genlerindeki intron bölgelerini çevreleyen tüm kodlama bölgesi sanger dizileme ile tespit edildi. Delesyonlar ve duplikasyonlar multipleks ligasyona bağımlı prob amplifikasyonu (MLPA) ile mutasyonlar tespit edildi.

Bulgular: Bölgemizde en sık rastlanan mutasyon tipi olan -3,7 / (%23,18), 3.7 kb’lık delesyon çalışmamızda da en sık olarak görülürken, diğer mutasyonların dağılımı ise --3,7 (%6,82), -3,7/-- MED (%0,91), --MED (%6,82), --20,5 (3,15), --SEA (%1,36), -4,2 (%0,95), triplikasyon (%0,45) ve nükleotid değişimleri (%4,55) olarak tespit edilmiştir.

Sonuç: Mevcut bilgiler ışığında genotipin fenotipe yansımasının da farklılıklar olması nedeniyle taşıyıcı bireylerin tesbit edilmesi ve genotip fenotip ilişkisinin netleştirilmesi açısından daha geniş popülasyon taramasına ihtiyaç duyulmaktadır. Toplumu alfa talasemi ve ağır klinik seyreden genetik hastalıklar hakkında bilinçlendirmek için taşıyıcı bireylere genetik danışmanlık verilmesi ve genetik çalışmalara ağırlık verilmesi bir gerekliliktir.
Stevens’ Catharsis in The Remains of the Day by Kazuo Ishiguro
Authors: SÜT GÜNGÖR Pınar
Published: May 2023

Consideration of the relationship between Aristotle’s and Sigmund Freud’s catharsis theories is significant to revise its efficacy in literature. The view is that the concept of catharsis in literature represents a process of purification and clearing, in which all repressed emotions, desires, and anguish come to the surface and, in this way, they are all eliminated from the psyche. This study establishes a recursive relationship between catharsis theory and Kazuo Ishiguro’s novel, The Remains of the Day. In this novel, Ishiguro narrates the story of an aging butler, Stevens, in disjointed periods and sporadic moments. Being full of regrets, Stevens reveals self-accustaions, mental repression, lack of objectivity, and fragmentation in moral, intellectual, and ethical senses. The Aristotelian and Freudian views on catharsis testify that the role of memory in Stevens’ case may form a discernible sample for purification. It has been confirmed that, being celebrated as a historically grounded book, The Remains of the Day exemplifies the true correlation between ‘telling’ and ‘release’ from a marginalized point of view.
State banks of Ukraine as a factor for ensuring monetary circulation stability under martial law
Authors:   SESE “The Academy of Financial Management”, LYUBICH Oleksandr , DROBIAZKO Anatolii ,   SESE “The Academy of Financial Management”, BORSHCHUK Oleksandr ,   SESE “The Academy of Financial Management”
Published: May 2023

Introduction. The results of the state-owned banks' activities (hereinafter BSC) in 2022 confirm their significant contribution to the stabilization of the national financial system during the period of full-scale Russian aggression against Ukraine. Problem Statement. Analysis of approaches to the strategic development of the BSC during the period of post-war economic recovery and their impact on the overall security of monetary circulation in the country. The given calculations make it possible to compare the financial results, role and place of each BSC with banks of foreign financial groups and banks with private capital. .Purpose. To assess the performance of banks with state participation in capital in 2022, compare the results obtained with the indicators of private sector banks, including with the participation of foreign capital, and formulate proposals for further legislative support for the optimization of business models of BSC in conditions of strengthening requirements for financial security. Methods. General scientific and special methods are used: analysis, synthesis, grouping, description, comparison, theoretical generalization and abstract-logical. Results. The dynamics of changes in the resource base of banks at the expense of legal entities and individuals, as well as their credit and investment portfolios, are presented. The main macroeconomic strategies of monetary policy, which influenced the development of banks in 2022, are considered. The importance of restoring the Government's cooperation with international financial organizations in 2023 is emphasized. Conclusions. Changes in the development strategy of the BSC are proposed in order to increase the capitalization of this sector and attract foreign capital in the direct investment of the banking sector. In the conditions of martial law, in order to ensure the manageability of the BSC it is advisable to review the list of key strategic indicators of banks from the point of view of unification and convenience for measuring and comparing the effectiveness of their management's work, as well as monitoring investment attractiveness. The financial security of Ukraine in the system of the bank-centric financial sector must be based on the transparent management of the BSC sector, which must have a long-term development strategy along with a transparent mechanism for evaluating the quality of management's work.
The African Union's Policy Capacity in the Governance of African Irregular Migration
Authors: Manga Edimo R. Mireille
Published: May 2023

Regional governance has become a significant policy challenge for the African States and Africa’s region, from managing defence, peace, poverty, economic integration, climate change, development issues to continental security. Irregular migration is one of the policy issues which acquired much significance in the early 2000s within the regional political agenda. In July 2001, the Organisation of African Union Council of Ministers (OAUCM) voiced the African states’ desideratum to develop a migration policy framework to face migration challenges upon the Continent. From that need, the 2006 Migration Policy Framework for Migration in Africa emerged. This paper questions the pre-emptive dimension of the African Union’s Migration Policy Framework for Africa (MPFA) to understand the weak ‘institutional capacity’ of the regional governance of irregular migration in Africa
Application of Sequencing Batch Biofilm Reactor (SBBR) Using Microalgae Chorella sp. to Removal Nutrient in Grey Water
Authors: Elystia Shinta , Kristin Rika , Andrio David
Published: May 2023

Grey water contains organic matter that is directly disposed to the environment without any treatment previously, will cause pollution and impacting life in the water. Treatment that can be done is using microorganisms. One of its kind is the microalgae Chlorella sp. which utilizes organic matter as a source of nutrients for its growth. In this study, the Kaldness 1 (K1) bio carrier was added as a medium for attaching microorganisms using the Sequencing Batch Biofilm Reactor (SBBR) process. The research objectives were (1) to know the maximum number of Chlorella sp. both attached and suspended in the Sequencing Batch Biofilm Reactor (SBBR), (2) to obtain the best cycle time and stabilization time in the removal of COD, Ammonia, and MLSS in grey water. The research was conducted by varying the stabilization time (1.5; 2 and 2.5 hours) in each cycle for four cycles with a constant variation of charging time 30 minutes, reaction 120 minutes, 45 minutes, separation 45 minutes, and carried out with four cycles, stirring speed at 60 rpm, the concentration of algae suspension in SBBR was 25% and the volume of Kaldness K1 medium was 20%. The results showed the number of microalgae cells Chlorella sp. was suspended and attached to 1.85 x 106 and 1.46 x 106 cells/ml. The best removal of COD, ammonia, and MLSS was found in the stabilization time variation of 1.5 hours in 4 cycles with a removal efficiency of 84% and 76%, respectively, and an increase in the concentration of suspended and attached MLSS by 4780 mg/l and 4720 mg/l. It can be concluded that the faster stabilization time, the more removal efficient will be.
Valorization of Waste Cooking Oil into Liquid Organic Fertilizer by Anaerobic Fermentation Method
Authors: Santoso Budi , Permatasari Arista Putri , Pratama Sisilia , Susmanto Prahady , Ningsih R.R. Yunita Bayu
Published: May 2023

Liquid organic fertilizer is a type of fertilizer that has a liquid form with a brownish color and is commonly used in agriculture as a supporting material for the main fertilizer. Liquid organic fertilizer can be produced through the fermentation process of organic matter, such as plant residues, animal or human waste, and organic waste so that it will not damage the environment. The manufacture of liquid organic fertilizer in this study uses waste cooking oil as raw material which will be fermented anaerobically for 21 days with the use of EM4 activator volume of 10 mL and 50 mL. This study was conducted to determine how much potential used cooking oil waste can be converted into liquid organic fertilizer. The results showed that the best concentration of nitrogen, phosphorus, potassium, and carbon organic in liquid organic fertilizer was obtained at 10 mL volume of EM4 activator. The best nitrogen concentration is 0.520 ppm, the best phosphorus concentration is 12.213 ppm, the best potassium concentration is 12013.825 ppm, and the best organic carbon concentration is 2.10%.
FORMAÇÃO DE PROFESSORES E RESOLUÇÃO DE PROBLEMAS NAS AULAS DE MATEMÁTICA: UM ESTUDO A PARTIR DE PESQUISAS BRASILEIRAS
Authors: Martins Kaique Nascimento , Pinca Sarro Gomes Larissa , Corrêa de Paula Marlúbia
Published: May 2023

Neste artigo, objetiva-se caracterizar a resolução de problemas na formação de professores que ensinam Matemática a partir da análise de investigações já concluídas; em particular, em teses e dissertações brasileiras. Para tanto, realizou-se um estudo do tipo Estado do Conhecimento, para localizar e selecionar pesquisas disponibilizadas na Biblioteca Digital Brasileira de Teses e Dissertações e no Catálogo de Teses e Dissertações da Capes. Para análise das produções, foi utilizada a Análise Textual Discursiva, com o auxílio do software IRaMuTeQ. Os resultados apontam para a importância de investigações que levem o participante a (re)construir o conhecimento sobre conteúdos/conceitos matemáticos e a refletir a respeito das práticas pedagógicas à luz da resolução de problemas. Nessa perspectiva, verificou-se, ainda, a necessidade de investigações futuras que considerem os professores em exercício no Ensino Superior e estudantes de cursos de Pedagogia.
PROPOSIÇÃO DE PROBLEMAS NOS ANOS INICIAIS: REFLEXÕES SOBRE ELEMENTOS DISPARADORES E PROMPT
Authors: Poffo Possamai Janaína , Allevato Norma Suely Gomes , Strelow Susane Barth
Published: May 2023

A proposição de problemas tem recebido atenção, mais recentemente, entre pesquisadores e educadores, sendo inserida em prescrições curriculares de diversos países, inclusive no Brasil. Um dos aspectos importantes a ser pesquisado nessa área, refere-se a compreender o impacto de diferentes atividades de proposição de problemas no desempenho dos estudantes e para os objetivos pedagógicos pretendidos pelo professor em sala de aula. Neste trabalho, nos concentramos em analisar problemas criados por crianças de 6 e 7 anos de idade, a partir dos elementos disparadores e do prompt que foram fornecidos. Para tanto, inicia-se apresentando uma discussão teórica acerca dos elementos que constituem o trabalho com a Proposição de Problemas em sala de aula. Na sequência, os dados são analisados por meio de abordagem qualitativa, considerando os problemas criados pelas crianças e entrevista realizada com uma delas, dadas as particularidades apresentadas no problema por ela proposto. Os resultados sugerem que as primeiras atividades de proposição de problemas com as crianças, sejam menos estruturadas, de modo que elas fiquem mais livres no que se refere a articular conhecimento matemático e vivências cotidianas, estruturando gradativamente o entendimento de como se constitui um problema no âmbito da Matemática.
O ENSINO DE FUNÇÃO AFIM POR MEIO DA RESOLUÇÃO DE PROBLEMAS
Authors: Silva Kelly de Souza , Pereira Lucília Batista Dantas
Published: May 2023

Este trabalho teve como objetivo principal verificar as contribuições do ensino de função afim por meio da Resolução de Problemas nas aulas de Matemática em turmas do 1° ano do Ensino Médio. A pesquisa foi realizada em duas turmas do 1° ano do Ensino Médio, em uma Escola Estadual localizada na área irrigada do município de Petrolina – PE, com um total de 41 alunos participantes. Para a realização deste trabalho de caráter qualitativo, utilizou-se de diário de campo para anotar todos os relatos, dúvidas e avanços de cada aluno durante a intervenção, a qual seguiu as dez etapas da Resolução de Problemas, conforme sugerida por Onuchic e Allevato (2011). Após a análise dos dados obtidos, os resultados apontaram que o ensino, por meio desta metodologia, atrelada a situações-problema presentes no cotidiano dos alunos, proporcionou uma mudança no comportamento dos envolvidos, ao despertar interesse para aprender mais, tanto nos alunos, quanto na professora-pesquisadora. A Resolução de Problemas se mostrou como uma estratégia eficaz, contribuindo, de maneira positiva, na aprendizagem dos estudantes.
UMA ANÁLISE DA METODOLOGIA RESOLUÇÃO DE PROBLEMAS PARA O ENSINO DE GEOMETRIA ESPACIAL NA FORMAÇÃO INICIAL DE PROFESSORES
Authors: Da Luz Barbosa Leandro , Ferreira Luciano , Secorun dos Santos Talita
Published: May 2023

O presente artigo tem como objetivo mostrar e analisar como a abordagem de ensino via Resolução de Problemas pode favorecer a prática docente no ensino de Geometria Espacial na formação inicial num curso de licenciatura em matemática. Para alcançar os objetivos da pesquisa, foram utilizadas cinco ações que concretizam o ensino via Resolução de Problemas, definidas por Proença, sendo elas: escolha do problema; introdução do problema; auxílio aos alunos durante a resolução; discussão das estratégias dos alunos e a articulação das estratégias dos alunos ao conteúdo. Tal implementação ocorreu em duas turmas de um curso de licenciatura em matemática de uma universidade pública do Estado do Paraná. Para a coleta de dados foram feitos dois questionários, um ao início da pesquisa, com questões abertas, para um diagnóstico da turma, e outro após a aplicação da atividade, com questões objetivas. Os resultados mostram que grande parte dos estudantes desconhecem essa abordagem, e ainda, possuem ideias desconexas do que realmente é, entretanto, após a aplicação da atividade, percebemos que a abordagem foi bem aceita pelos futuros professores, uma vez que consideraram utilizar a abordagem quando formados. Nesse sentido, torna-se necessária a reflexão acerca do uso de diferentes metodologias e abordagens de ensino de matemática, de modo a aumentar o leque de conhecimentos dos estudantes para que estes possam, quando professores, atuarem de maneira significativa no que se refere às práticas de ensino
PENSAMENTO ALGÉBRICO E RESOLUÇÃO DE PROBLEMAS: POSSIBILIDADES NA FORMAÇÃO DE PROFESSORES
Authors: Da Silva Landgraf Ariane , Maria Justulin Andresa
Published: May 2023

O presente trabalho tem como objetivo identificar contribuições de um curso de formação docente com foco no pensamento algébrico e na resolução de problemas. O curso, responsável pela geração de dados, foi ofertado remotamente na modalidade de extensão, com encontros síncronos, atividades assíncronas, discussões teóricas e momentos práticos, envolvendo a Metodologia de Ensino-Aprendizagem-Avaliação de Matemática através da Resolução de Problemas. Seis professores participaram da proposta, os quais atuavam desde os Anos Iniciais do Ensino Fundamental até o Ensino Médio. Metodologicamente, a pesquisa desenvolvida configura-se como qualitativa e os instrumentos utilizados para coleta de dados abarcaram questionários, registros escritos produzidos e compartilhados pelos participantes durante o curso e transcrições dos áudios produzidos. Para a análise dos dados, foi realizada uma triangulação entre o referencial teórico e os elementos evidenciados. Os resultados demonstram que, após o curso, houve uma mudança no planejamento das aulas por parte dos professores, bem como uma valorização dos conhecimentos prévios dos alunos, além da alteração no tipo de problema proposto em uma aula de resolução de problemas e na conduta do professor como mediador.