bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of a Practical-Based Ohmic Series Resistance Model under Life-Cycle Changes for a Lithium-Ion Battery
Authors: Somakettarin Natthawuth , Pichetjamroen Achara
Published: October 2019

Understanding battery characteristic behaviors is indispensable in designing and managing large-scale battery-based energy storage systems in high-power applications. This paper presents a practical-based characterization method to model the ohmic series resistance of lithium-ion batteries under life-cycle consideration. Aging cells were prepared in a controlled environment, and the testing information was automatically characterized using a developed computer-based battery test system. An experimental methodology based on the cycling of pulse tests is applied for modeling the ohmic series resistance. Several aspects of the testing parameters during the cycling operations, such as the characteristic changes of the ohmic series resistance, amplitudes of the periodic test current, cell capacity, state of charge, and the rate of change of the resistance increment, are also investigated and analyzed so as to fulfill the resistance model. The accuracy of the proposed model is verified by comparing the testing information, showing a satisfactory result.
Environmental and Efficiency Analysis of Simulated Application of the Solid Oxide Fuel Cell Co-Generation System in a Dormitory Building
Authors: Chang Han , Lee In-Hee
Published: October 2019

The problem of air pollution in Korea has become progressively more serious in recent years. Since electricity is advertised as clean energy, some newly developed buildings in Korea are using only electricity for all energy needs. In this research, the annual amount of air pollution attributable to energy under the traditional method in a dormitory building, which is supplying both natural gas and electricity to the building, was compared with the annual amount of air pollution attributable to supplying only electricity. The results showed that the building using only electricity emits much more air pollution than the building using electricity and natural gas together. Under the traditional method of energy supply, a residential solid oxide fuel cell cogeneration system (SOFC–CGS) for minimizing environmental pollution of the building was simulated. Furthermore, as a high load factor could lead to high efficiency of the SOFC–CGS, sharing of the SOFC–CGS by multi-households could increase its efficiency. Finally, the environmental pollution from using one system in one household was compared with that from sharing one system by multi-households. The results showed that the environmental pollution from sharing the system was relatively higher but still similar to that when using one system in one household.
Interior Insulation of Masonry Walls—Selected Problems in the Design
Authors: Orlik-Kożdoń Bożena
Published: October 2019

This article addresses the important problem of improving the energy efficiency of historic buildings, where due to the architectural value of the facade, thermal insulation should be placed from the inside. As a part of this publication, the author, on the basis of their own experience and research, presents and discusses selected problems to which special attention should be paid when designing this type of insulation. These are among other things: disturbances in the distribution of the temperature field on the partition; defects related to partial thermal insulation of partitions; the lack of detailed analysis of wall systems in terms of construction and their technical condition; wood decay; the selection of inadequate calculation methods, e.g., the simple method of Fokin–Glaser and many others. The author, on the basis of measurements and computational analysis, presents the methodology of a correct solution of such problems. This significantly simplifies currently applied methods.
Numerical Analysis of End-Gas Autoignition and Pressure Oscillation in a Downsized SI Engine Using Large Eddy Simulation
Authors: Zhong Lijia , Liu Changwen
Published: October 2019

Knock and super-knock are abnormal combustion phenomena in engines, however, they are hard to study comprehensively through optical experimental methods due to their inherent destructive nature. In present work, the methodology of large eddy simulation (LES) coupled with G equations and a detailed mechanism of primary reference fuel (PRF) combustion is utilized to address the mechanisms of knock and super-knock phenomena in a downsized spark ignition gasoline engine. The knock and super-knock with pressure oscillation are qualitatively duplicated through present numerical models. As a result, the combustion and onset of autoignition is more likely to occur at top dead center (TDC), which causes end gas at a higher temperature and pressure. It is reasonable to conclude that the intensity of knock is not only proportional to the mass fraction of mixtures burned by the autoignition flame but the thermodynamics of the unburned end-gas mixture, and the effect of thermodynamics is more important. It also turns out that two auto-ignitions occur in conventional knock conditions, while only one auto-ignition takes place in super-knock conditions. However, the single autoignition couples with the pressure wave and they reinforce each other, which eventually evolves into detonation combustion. This work gives the valuable insights into knock phenomena in spark ignition gasoline engines.
Preface: Special Issue on Environmental Impact of Nature-Based Tourism
Authors: Green Ronda J. , Croft David B. , Wolf Isabelle D.
Published: October 2019

Tourism is growing rapidly throughout the world, including nature-based tourism, but natural habitats are shrinking [...]
Formation of Food Grade Microemulsion with Rice Glycosphingolipids to Enhance the Oral Absorption of Coenzyme Q10
Authors: Uchiyama Hiromasa , Chae Jisoon , Kadota Kazunori , Tozuka Yuichi
Published: October 2019

The purpose of this study is to examine the possible use of rice glycosphingolipids (RGSLs) as an emulsifier to form food grade microemulsions (mean particle size, 10–20 nm) and improve the absorption of CoQ10 with a poor solubility property by prepared emulsion. Because RGSLs could act as an auxiliary emulsifying agent, its addition to the surfactant/oil mixture decreased the emulsion’s particle size. This suggests that RGSLs exist between the water and oil phases to decrease oil droplet size via reduced interfacial tension. CoQ10-loaded microemulsion was also successfully prepared with RGSLs and powdered after freeze-drying with a cryoprotectant. CoQ10’s solubility in freeze-dried particles was dramatically improved compared to that of CoQ10 powder. Moreover, oral absorption of CoQ10 was significantly enhanced when administered via CoQ10-loaded microemulsion. The area under the plasma concentration–time curve for the microemulsion improved up to seven-fold compared to CoQ10 powder. The use of RGSLs could, therefore, be an effective processing technique for improving CoQ10’s solubility and absorption.
Interprofessional Education and Collaboration in Healthcare: An Exploratory Study of the Perspectives of Medical Students in the United States
Authors: Zechariah Sunitha , Ansa Benjamin E. , Johnson Stephanie W. , Gates Amy M. , Leo Gianluca De
Published: October 2019

Qualified and competent healthcare professionals working in a collaborative team environment is a prerequisite for high quality patient care. In order to be successful in the healthcare working environment, medical students need to be exposed to interprofessional learning early in their education. A single stage online survey was administered to medical students to evaluate their attitudes and perceptions of interprofessional education (IPE) and whether prior exposure to IPE increased their appreciation for interprofessional collaboration. The results suggest that irrespective of prior exposure to IPE, medical students appreciated the importance of interprofessional education and collaboration. Medical students showed a strong interest in attending interprofessional courses in other disciplines. Time constraints, scheduling conflicts, and communication emerged as barriers to IPE. Medical students embraced IPE and welcomed the opportunity to learn with other disciplines. Clinical case studies and simulations were identified as potential methods to integrate with other healthcare disciplines. The positive attitude and perceptions of the medical students toward interprofessional education and collaboration warrants the inclusion of related courses in medical curricula, as this may further increase students’ potentials in becoming effective healthcare providers.
Understanding the Role of Academic Partners as Technical Assistance Providers: Results from an Exploratory Study to Address Precarious Work
Authors: Bonney Tessa , Welter Christina , Jarpe-Ratner Elizabeth , Conroy Lorraine
Published: October 2019

Universities may be well poised to support knowledge, skill, and capacity-building efforts to foster the development of multi-level interventions to address complex problems. Researchers at the University of Illinois at Chicago (UIC) engaged organizations interested in developing policy- and systems-level initiatives to address the drivers of precarious work in a six-meeting Action Learning (AL) process, in which the researchers served as technical assistance (TA) providers focused on facilitating learning and promoting critical thinking among participants. This exploratory qualitative study examined the role, facilitators, challenges, and impacts of university facilitation in this context. A total of 22 individuals participated in this study, including UIC TA providers, content expert TA providers from labor-focused organizations, and TA recipients from health-focused organizations. Results from interviews and a focus group highlight the utility of a university connecting organizations from different disciplines that do not traditionally work together, and suggest that the TA provided by UIC helped participants think concretely about precarious work and ways in which their organizations might work collaboratively to bring about sustainable change. Findings from this study suggest that university facilitation using an AL approach may be effective in increasing knowledge to action.
Regionalization and Partitioning of Soil Health Indicators for Nigeria Using Spatially Contiguous Clustering for Economic and Social-Cultural Developments
Authors: Boluwade Alaba
Published: October 2019

Understanding the spatial variability of soil health and identifying areas that share similar soil properties can help nations transition to sustainable agricultural practices. This information is particularly applicable to management decisions such as tillage, nutrient application, and soil and water conservation. This study evaluated the spatial variability and derived the optimal number of spatially contiguous regions of Nigeria’s 774 Local Government Areas (LGAs) using three soil health indicators, organic carbon (OC), bulk density (BD) and total nitrogen (TN) extracted from the Africa Soil Information Service database. Missing data were imputed using the random forest imputation method with topography and normalized difference vegetation index (NDVI) as auxiliary variables. Using an exponential covariance function, the spatial ranges for BD, SN, and OC were calculated as 18, 42, and 60 km, respectively. These were the maximum distances at which there was no correlation between the sample data points. This finding suggests that OC has high variability across Nigeria as compared with other tested indicators. The ordinary kriging (OK) technique revealed spatial dependency (positive correlation) among TN and OC on interpolated surfaces, with high values in the southern part of the county and low values in the north. The BD values were also high in the northern regions where the soils are sandy; correspondingly, TN and OC had low values. The “regionalization with dynamically constrained agglomerative clustering and partitioning” (REDCAP) technique was used to divide LGAs into a possible number of regions while optimizing a sum of squares deviation (SSD). Optimal division was not observed in the resulting number of regional partitions. Conducting the Markov Chain Monte Carlo (MCMC) method on within-zone heterogeneity (WZH) revealed three partitions (two, five, and 15 regions) as optimal, in other words, there would be no significant change in WZH after three partitions. Ensuring a proper understanding of soil spatial variability and heterogeneities (or homogeneities) could facilitate agricultural planning that combines or merges state and local governments that share the same soil health properties, rather than basing decisions on geopolitical, racial, or ethnoreligious factors. The findings of this study could be applied to understand the importance of soil heterogeneities in hydrologic modeling applications. In addition, the findings may aid decision-making bodies such as the United Nations’ Food and Agricultural Organization, the International Fund for Agricultural Development, or the World Bank in their efforts to alleviate poverty, meet future food needs, mitigate the impacts of climate change, and provide financial funding through sustainable agriculture and intervention in developing countries such as Nigeria.
Rett Syndrome and CDKL5 Deficiency Disorder: From Bench to Clinic
Authors: Kadam Shilpa D. , Sullivan Brennan J. , Goyal Archita , Blue Mary E. , Smith-Hicks Constance
Published: October 2019

Rett syndrome (RTT) and CDKL5 deficiency disorder (CDD) are two rare X-linked developmental brain disorders with overlapping but distinct phenotypic features. This review examines the impact of loss of methyl-CpG-binding protein 2 (MeCP2) and cyclin-dependent kinase-like 5 (CDKL5) on clinical phenotype, deficits in synaptic- and circuit-homeostatic mechanisms, seizures, and sleep. In particular, we compare the overlapping and contrasting features between RTT and CDD in clinic and in preclinical studies. Finally, we discuss lessons learned from recent clinical trials while reviewing the findings from pre-clinical studies.
Prion Protein in Glioblastoma Multiforme
Authors: Ryskalin Larisa , Busceti Carla L. , Biagioni Francesca , Limanaqi Fiona , Familiari Pietro , Frati Alessandro , Fornai Francesco
Published: October 2019

The cellular prion protein (PrPc) is an evolutionarily conserved cell surface protein encoded by the PRNP gene. PrPc is ubiquitously expressed within nearly all mammalian cells, though most abundantly within the CNS. Besides being implicated in the pathogenesis and transmission of prion diseases, recent studies have demonstrated that PrPc contributes to tumorigenesis by regulating tumor growth, differentiation, and resistance to conventional therapies. In particular, PrPc over-expression has been related to the acquisition of a malignant phenotype of cancer stem cells (CSCs) in a variety of solid tumors, encompassing pancreatic ductal adenocarcinoma (PDAC), osteosarcoma, breast cancer, gastric cancer, and primary brain tumors, mostly glioblastoma multiforme (GBM). Thus, PrPc is emerging as a key in maintaining glioblastoma cancer stem cells’ (GSCs) phenotype, thereby strongly affecting GBM infiltration and relapse. In fact, PrPc contributes to GSCs niche’s maintenance by modulating GSCs’ stem cell-like properties while restraining them from differentiation. This is the first review that discusses the role of PrPc in GBM. The manuscript focuses on how PrPc may act on GSCs to modify their expression and translational profile while making the micro-environment surrounding the GSCs niche more favorable to GBM growth and infiltration.
ATP-Evoked Intracellular Ca2+ Responses in M-CSF Differentiated Human Monocyte-Derived Macrophage are Mediated by P2X4 and P2Y11 Receptor Activation
Authors: Layhadi Janice A. , Fountain Samuel J.
Published: October 2019

Tissues differentially secrete multiple colony stimulating factors under conditions of homeostasis and inflammation, orientating recruited circulating monocytes to differentiate to macrophage with differing functional phenotypes. Here, we investigated ATP-evoked intracellular Ca2+ responses in human macrophage differentiated with macrophage colony-stimulating factor (M-CSF). Extracellular ATP evoked (EC50 13.3 ± 1.4 μM) robust biphasic intracellular Ca2+ responses that showed a dependency on both metabotropic (P2Y) and ionotropic (P2X) receptors. qRT-PCR and immunocytochemistry revealed the expression of P2Y1, P2Y2, P2Y6, P2Y11, P2Y13, P2X1, P2X4, P2X5, and P2X7. Pharmacological analysis revealed contribution of only P2X4 and P2Y11 to the Ca2+ response evoked by maximal ATP concentrations (100 µM). This study reveals the contribution of P2X4 and P2Y11 receptor activation to ATP-evoked intracellular Ca2+ responses, and makes comparison with macrophage differentiated using granulocyte colony-stimulating factor (GM-CSF).
Variation in an Extreme Weapon: Horn Performance Differences across Rhinoceros Beetle (Trypoxylus dichotomus) Populations
Authors: Buchalski Benjamin , Gutierrez Eric , Emlen Douglas , Lavine Laura , Swanson Brook
Published: October 2019

Japanese rhinoceros beetle (Trypoxylus dichotomus) males have exaggerated head horns that they use as weapons in combat over reproductive opportunities. In these contests, there is an advantage to having a longer horn, and there seems to be little cost to horn exaggeration. However, populations vary in the amount of horn exaggeration across this widespread species. Here, we examine four populations and quantify scaling and functional morphology of the horn. We then measure force production by the horn system in a combat-relevant movement. We find that not only does horn length vary among populations, but allometry of lever mechanics and force production varies in a complex way. For instance, some beetle populations make relatively long horns, but exert relatively low forces. Other populations make shorter horns and produce higher forces during fights. We suggest that this performance variation could be associated with differences in the intensity or type of sexual selection across the species.
Liver Grafts with Major Extended Donor Criteria May Expand the Organ Pool for Patients with Hepatocellular Carcinoma
Authors: Lozanovski Vladimir , Kerr Larissa , Khajeh Elias , Ghamarnejad Omid , Pfeiffenberger Jan , Hoffmann Katrin , Chang De-Hua , Mieth Markus , Longerich Thomas , Strobel Oliver , Weiss Karl , Büchler Markus , Mehrabi Arianeb
Published: October 2019

The major extended donor criteria (maEDC; steatosis >40%, age >65 years, and cold ischemia time >14 h) influence graft and patient outcomes after liver transplantation. Despite organ shortages, maEDC organs are often considered unsuitable for transplantation. We investigated the outcomes of maEDC organ liver transplantation in patients with hepatocellular carcinoma (HCC). Two hundred and sixty-four HCC liver transplant patients were eligible for analysis. Risk factor analysis was performed for early allograft dysfunction; primary nonfunction; 30-day and 90-day graft failure; and 30-day, 90-day, and 1-year patient mortality. One-year graft survival was higher in recipients of no-maEDC grafts. One-year patient survival did not differ between the recipients of no-maEDC and maEDC organs. The univariate and multivariate analyses revealed no association between maEDC grafts and one-year patient mortality. Graft survival differed between the recipients of no-maEDC and maEDC organs after correcting for a laboratory model of end-stage liver disease (labMELD) score with a cut-off value of 20, but patient survival did not. Patient survival did not differ between recipients who did and did not meet the Milan criteria and who received grafts with and without maEDC. Instead of being discarded, maEDC grafts may expand the organ pool for patients with HCC without impairing patient survival or recurrence-free survival.
Comparison of Concrete Creep in Compression, Tension, and Bending under Drying Condition
Authors: Kim Seung-Gyu , Park Yeong-Seong , Lee Yong-Hak
Published: October 2019

Three types of creep experiments of compression, tension, and bending were implemented to identify quantitative relations among the three types of creep under drying atmospheric conditions. In case of the bending creep experiment, two types of unreinforced concrete beams with similar dimensions were cast for use in the beam creep and shrinkage tests. The variations in the shrinkage strain within the beam depth were measured to evaluate the effect of the shrinkage variations on the bending creep strain. The beam creep strain measured within the beam depth was composed of uniform and skewed parts. The skewed parts of the creep strain were found to be dominant whereas the uniform parts were small enough to be neglected in the bending creep evaluation. This indicated that the compressive bending creep at the top surface was close to the tensile bending creep at the bottom surface. The ratios of tensile and bending creep strains to compressive creep strain were approximately 2.9 and 2.3, respectively, and the ratio of bending creep strain to tensile creep strain was approximately 0.8. Particular attention is laid on the close agreement between tensile and compressive bending creep strains even if the creep in tension is 2.9 times larger than the creep strain in compression.
FeS2/C Nanowires as an Effective Catalyst for Oxygen Evolution Reaction by Electrolytic Water Splitting
Authors: Pan Kefeng , Zhai Yingying , Zhang Jiawei , Yu Kai
Published: October 2019

Electrolytic water splitting with evolution of both hydrogen (HER) and oxygen (OER) is an attractive way to produce clean energy hydrogen. It is critical to explore effective, but low-cost electrocatalysts for the evolution of oxygen (OER) owing to its sluggish kinetics for practical applications. Fe-based catalysts have advantages over Ni- and Co-based materials because of low costs, abundance of raw materials, and environmental issues. However, their inefficiency as OER catalysts has caused them to receive little attention. Herein, the FeS2/C catalyst with porous nanostructure was synthesized with rational design via the in situ electrochemical activation method, which serves as a good catalytic reaction in the OER process. The FeS2/C catalyst delivers overpotential values of only 291 mV and 338 mV current densities of 10 mA/cm2 and 50 mA/cm2, respectively, after electrochemical activation, and exhibits staying power for 15 h.
The Effect of Coating Density on Functional Properties of SiNx Coated Implants
Authors: Filho Luimar Correa , Schmidt Susann , López Alejandro , Cogrel Mathilde , Leifer Klaus , Engqvist Håkan , Högberg Hans , Persson Cecilia
Published: October 2019

Ceramic coatings may be applied onto metallic components of joint replacements for improved wear and corrosion resistance as well as enhanced biocompatibility, especially for metal-sensitive patients. Silicon nitride (SiNx) coatings have recently been developed for this purpose. To achieve a high coating density, necessary to secure a long-term performance, is however challenging, especially for sputter deposited SiNx coatings, since these coatings are insulating. This study investigates the time-dependent performance of sputter-deposited SiNx based coatings for joint applications. SiNx coatings with a thickness in the range of 4.3–6.0 µm were deposited by reactive high power impulse magnetron sputtering onto flat discs as well as hip heads made of CoCrMo. SiNx compositional analysis by X-ray photoelectron spectroscopy showed N/Si ratios between 0.8 and 1.0. Immersion of the flat disks in fetal bovine serum solution over time as well as short-term wear tests against ultra-high molecular weight polyethylene (UHMWPE) discs showed that a high coating density is required to inhibit tribocorrosion. Coatings that performed best in terms of chemical stability were deposited using a higher target power and process heating.
Hepatic Metabolic Derangements Triggered by Hyperthermia: An In Vitro Metabolomic Study
Authors: Araújo Ana Margarida , Enea Maria , Carvalho Félix , Bastos Maria de Lourdes , Carvalho Márcia , Guedes de Pinho Paula
Published: October 2019

Background and aims: Liver toxicity is a well-documented and potentially fatal adverse complication of hyperthermia. However, the impact of hyperthermia on the hepatic metabolome has hitherto not been investigated. Methods: In this study, gas chromatography-mass spectrometry (GC-MS)-based metabolomics was applied to assess the in vitro metabolic response of primary mouse hepatocytes (PMH, n = 10) to a heat stress stimulus, i.e., after 24 h exposure to 40.5 °C. Metabolomic profiling of both intracellular metabolites and volatile metabolites in the extracellular medium of PMH was performed. Results: Multivariate analysis showed alterations in levels of 22 intra- and 59 extracellular metabolites, unveiling the capability of the metabolic pattern to discriminate cells exposed to heat stress from cells incubated at normothermic conditions (37 °C). Hyperthermia caused a considerable loss of cell viability that was accompanied by significant alterations in the tricarboxylic acid cycle, amino acids metabolism, urea cycle, glutamate metabolism, pentose phosphate pathway, and in the volatile signature associated with the lipid peroxidation process. Conclusion: These results provide novel insights into the mechanisms underlying hyperthermia-induced hepatocellular damage.
Comparison of Multivariate Regression Models Based on Water- and Carbohydrate-Related Spectral Regions in the Near-Infrared for Aqueous Solutions of Glucose
Authors: Beganović Anel , Moll Vanessa , Huck Christian W.
Published: October 2019

The predictive power of the two major water bands centered at 6900 cm - 1 and 5200 cm - 1 in the near-infrared (NIR) region was compared to carbohydrate-related spectral areas located in the first overtone (around 6000 cm - 1 ) and combination (around 4500 cm - 1 ) region using glucose in aqueous solutions as a model substance. For the purpose of optimal coverage of stronger as well as weaker absorbing NIR regions, cells with three different declared optical pathlengths were employed. The sample set consisted of multiple separately prepared batches in the range of 50–200 mmol/L. Moreover, the samples were divided into a calibration set for the construction of the partial least squares regression (PLS-R) models and a test set for the validation process with independent samples. The first overtone and combination region showed relative prediction errors between 0.4–1.6% with only one PLS-R factor required. On the other hand, the errors for the water bands were found between 1.6–8.3% and up to three PLS-R factors required. The best PLS-R models resulted from the cell with 1 mm optical pathlength. In general, the results suggested that the carbohydrate-related regions in the first overtone and combination region should be preferred over the regions of the two dominant water bands.
Photocatalytic Degradation of Pharmaceuticals Carbamazepine, Diclofenac, and Sulfamethoxazole by Semiconductor and Carbon Materials: A Review
Authors: Mestre Ana S. , Carvalho Ana P.
Published: October 2019

The presence of pharmaceutical compounds in the environment is a reality that calls for more efficient water treatment technologies. Photocatalysis is a powerful technology available but the high energy costs associated with the use of UV irradiation hinder its large scale implementation. More sustainable and cheaper photocatalytic processes can be achieved by improving the sunlight harvesting and the synthesis of semiconductor/carbon composites has proved to be a promising strategy. Carbamazepine, diclofenac, and sulfamethoxazole were selected as target pharmaceuticals due to their recalcitrant behavior during conventional wastewater treatment and persistence in the environment, as properly reviewed. The literature data on the photocatalytic removal of carbamazepine, diclofenac, and sulfamethoxazole by semiconductor/carbon materials was critically revised to highlight the role of the carbon in the enhanced semiconductor performance under solar irradiation. Generally it was demonstrated that carbon materials induce red-shift absorption and they contribute to more effective charge separation, thus improving the composite photoactivity. Carbon was added as a dopant (C-doping) or as support or doping materials (i.e., nanoporous carbons, carbon nanotubes (CNTs), graphene, and derived materials, carbon quantum dots (CQDs), and biochars) and in the large majority of the cases, TiO2 was the semiconductor tested. The specific role of carbon materials is dependent on their properties but even the more amorphous forms, like nanoporous carbons or biochars, allow to prepare composites with improved properties compared to the bare semiconductor. The self-photocatalytic activity of the carbon materials was also reported and should be further explored. The removal and mineralization rates, as well as degradation pathways and toxicity of the treated solutions were also critically analyzed.
C–H-Bond Activation and Isoprene Polymerization Studies Applying Pentamethylcyclopentadienyl-Supported Rare-Earth-Metal Bis(Tetramethylaluminate) and Dimethyl Complexes
Authors: Hollfelder Christoph O. , Meermann-Zimmermann Melanie , Spiridopoulos Georgios , Werner Daniel , Törnroos Karl W. , Maichle-Mössmer Cäcilia , Anwander Reiner
Published: October 2019

As previously shown for lutetium and yttrium, 1,2,3,4,5-pentamethylcyclopentadienyl (C5Me5 = Cp*)-bearing rare-earth metal dimethyl half-sandwich complexes [Cp*LnMe2]3 are now also accessible for holmium, dysprosium, and terbium via tetramethylaluminato cleavage of [Cp*Ln(AlMe4)2] with diethyl ether (Ho, Dy) and tert-butyl methyl ether (TBME) (Tb). C–H-bond activation and ligand redistribution reactions are observed in case of terbium and are dominant for the next larger-sized gadolinium, as evidenced by the formation of mixed methyl/methylidene clusters [(Cp*Ln)5(CH2)(Me)8] and metallocene dimers [Cp*2Ln(AlMe4)]2 (Ln = Tb, Gd). Applying TBME as a “cleaving” reagent can result in both TBME deprotonation and ether cleavage, as shown for the formation of the 24-membered macrocycle [(Cp*Gd)2(Me)(CH2OtBu)2(AlMe4)]4 or monolanthanum complex [Cp*La(AlMe4){Me3Al(CH2)OtBu}] and monoyttrium complex [Cp*Y(AlMe4)(Me3AlOtBu)], respectively. Complexes [Cp*Ln(AlMe4)2] (Ln = Ho, Dy, Tb, Gd) and [Cp*LnMe2]3 (Ln = Ho, Dy) are applied in isoprene and 1,3-butadiene polymerization, upon activation with borates [Ph3C][B(C6F5)4] and [PhNHMe2][B(C6F5)4], as well as borane B(C6F5)3. The trans-directing effect of AlMe3 in the binary systems [Cp*Ln(AlMe4)2]/borate is revealed and further corroborated by the fabrication of high-cis-1,4 polybutadiene (97%) with “aluminum-free” [Cp*DyMe2]3/[Ph3C][B(C6F5)4]. The formation of multimetallic active species is supported by the polymerization activity of pre-isolated cluster [(Cp*Ho)3Me4(CH2)(thf)2].
In-Vitro Antioxidant, Hypoglycemic Activity, and Identification of Bioactive Compounds in Phenol-Rich Extract from the Marine Red Algae Gracilaria edulis (Gmelin) Silva
Authors: Gunathilaka Thilina L. , Samarakoon Kalpa W. , Ranasinghe P. , Peiris L. Dinithi C.
Published: October 2019

Obesity and diabetes are major metabolic disorders which are prevalent worldwide. Algae has played an important role in managing these disorders. In this study, Gracilaria edulis, a marine red algae, was investigated for antioxidant and hypoglycemic potential using in vitro models. De-polysaccharide methanol extract of G. edulis was sequentially partitioned with hexane, chloroform, ethyl acetate, and antioxidants, and hypoglycemic potentials were evaluated using multiple methods. High antioxidant potential was observed in the ethyl acetate fraction in terms of ferric reducing antioxidant power, iron chelating, and DPPH and ABTS radical scavenging activities, while the crude methanol extract exhibited potent oxygen radical-absorbance capacity. Potent α-amylase inhibitory activity was observed in the ethyl acetate fraction, while the ethyl acetate fraction was effective against α-glucosidase inhibition. Glucose diffusion was inhibited by the ethyl acetate fraction at 180 min, and the highest antiglycation activity was observed in both chloroform and ethyl acetate fractions. Additionally, gas chromatography-mass spectrometry analysis of the ethyl acetate fraction revealed the presence of several potent anti-diabetic compounds. In conclusion, G. edulis exhibited promising antidiabetic potential via multiple mechanisms. The ethyl acetate fraction exhibited the strongest hypoglycemic and antiglycation potential among the four fractions, and hence the isolation of active compounds is required to develop leads for new drugs to treat diabetes.
Kynurenines and the Endocannabinoid System in Schizophrenia: Common Points and Potential Interactions
Authors: Zádor Ferenc , Nagy-Grócz Gábor , Kekesi Gabriella , Dvorácskó Szabolcs , Szűcs Edina , Tömböly Csaba , Horvath Gyongyi , Benyhe Sándor , Vécsei László
Published: October 2019

Schizophrenia, which affects around 1% of the world’s population, has been described as a complex set of symptoms triggered by multiple factors. However, the exact background mechanisms remain to be explored, whereas therapeutic agents with excellent effectivity and safety profiles have yet to be developed. Kynurenines and the endocannabinoid system (ECS) play significant roles in both the development and manifestation of schizophrenia, which have been extensively studied and reviewed previously. Accordingly, kynurenines and the ECS share multiple features and mechanisms in schizophrenia, which have yet to be reviewed. Thus, the present study focuses on the main common points and potential interactions between kynurenines and the ECS in schizophrenia, which include (i) the regulation of glutamatergic/dopaminergic/γ-aminobutyric acidergic neurotransmission, (ii) their presence in astrocytes, and (iii) their role in inflammatory mechanisms. Additionally, promising pharmaceutical approaches involving the kynurenine pathway and the ECS will be reviewed herein.
Explanation for the Multi-Component Scintillation of Cerium Fluoride Through the Equilibrium and Photophysical Investigation of Cerium(III)-Fluoro Complexes
Authors: Valicsek Zsolt , Kovács Máté , Horváth Ottó
Published: October 2019

CeF3 displays favorable scintillation properties, which have been utilized for decades in various solid-state systems. Its emission undergoes multi-component decays, which were interpreted by lattice defects and so-called intrinsic features herein. This study of the complex equilibria in connection with photophysical behavior of the cerium(III)-fluoride system in solution gave us the possibility to reveal the individual contribution of the [CeIIIFx(H2O)9−x]3−x species to the photoluminescence. Spectrophotometry and spectrofluorometry (also in time-resolved mode) were used, and combined with sophisticated evaluation methods regarding both the complex equilibria and the kinetics of the photoinduced processes. The individual photophysical parameters of the [CeIIIFx(H2O)9−x]3−x complexes were determined. For the kinetic evaluation, three methods of various simplifications were applied and compared. The results indicated that the rates of some excited-state equilibrium processes were comparable to those of the emission decay steps. Our results also contribute to the explanation of the multi-component emission decays in the CeF3-containing scintillators, due to the various coordination environments of Ce3+, which can be affected by the excitation leading to the dissociation of the metal-ligand bonds.
Day-Time Patterns of Carbohydrate Intake in Adults by Non-Parametric Multi-Level Latent Class Analysis—Results from the UK National Diet and Nutrition Survey (2008/09–2015/16)
Authors: Wang Chaochen , Almoosawi Suzana , Palla Luigi
Published: October 2019

This study aims at combining time and quantity of carbohydrate (CH) intake in the definition of eating patterns in UK adults and investigating the association of the derived patterns with type 2 diabetes (T2D). The National Diet and Nutrition Survey (NDNS) Rolling Program included 6155 adults in the UK. Time of the day was categorized into 7 pre-defined time slots: 6–9 am, 9–12 noon, 12–2 pm, 2–5 pm, 5–8 pm, 8–10 pm, and 10 pm–6 am. Responses for CH intake were categorized into: no energy intake, CH <50% or ≥50% of total energy. Non-parametric multilevel latent class analysis (MLCA) was applied to identify eating patterns of CH consumption across day-time, as a novel method accounting for the repeated measurements of intake over 3–4 days nested within individuals. Survey-designed multivariable regression was used to assess the associations of CH eating patterns with T2D. Three CH eating day patterns (low, high CH percentage and regular meal CH intake day) emerged from 24,483 observation days; based on which three classes of CH eaters were identified and characterized as: low (28.1%), moderate (28.8%) and high (43.1%) CH eaters. On average, low-CH eaters consumed the highest amount of total energy intake (7985.8 kJ) and had higher percentages of energy contributed by fat and alcohol, especially after 8 pm. Moderate-CH eaters consumed the lowest amount of total energy (7341.8 kJ) while they tended to have their meals later in the day. High-CH eaters consumed most of their carbohydrates and energy earlier in the day and within the time slots of 6–9 am, 12–2 p.m. and 5–8 pm, which correspond to traditional mealtimes. The high-CH eaters profile had the highest daily intake of CH and fiber and the lowest intake of protein and fat. Low-CH eaters had greater odds than high-CH eaters of having T2D in self-reported but not in previously undiagnosed diabetics. Further research using prospective longitudinal studies is warranted to ascertain the direction of causality in the association of CH patterns with type 2 diabetes.
Effect of Assisted Ultrasonication and Ozone Pretreatments on Sludge Characteristics and Yield of Biogas Production
Authors: Le Tuan Minh , Vo Phong Thanh , Do Tuan Anh , Tran Lien Thi , Truong Hoa Thi , Xuan Le Thanh Thao , Chen Yi-Hung , Chang Chia-Chi , Chang Ching-Yuan , Tran Quoc Toan , Thanh Tran , Do Manh Van
Published: October 2019

The effects of ultrasonic and ozonation pretreatments on organic solubilization, anaerobic biodegradability, and biogas production were elucidated in this study. Two pretreatment methods for batch anaerobic digestion for biogas recovery with the same material and experimental conditions were the focus for comparison. Anaerobic digestion experiments were conducted at ambient temperature with the solid retention time set to 25 days. The obtained results indicated that the soluble chemical oxygen demand increased from 0.344 without pretreatment to 1.023 and 1.228 g/L with ultrasound and ozone pretreatments, respectively, whereas the yields of biogas production in the 25 days increased by 32.3 and 52.9% via ultrasonic irradiation and ozonation relative to the control case, respectively. The biodegradability of the organic compounds of the samples for the cases of ultrasound, ozone pretreatments, and control achieved 55.9, 64.31, and 39.18%, respectively, in terms of chemical oxygen demand (COD) removal efficiencies. The physicochemical characteristics of sludge flocs were investigated via scanning with particle sizes, which were obviously affected by pretreatments of sonication and ozonation, resulting in finer particles than in the control case.
A Study of Cake Filtration Parameters Using the Constant Rate Process
Authors: Mahdi Faiz , Hunter Timothy , Holdich Richard
Published: October 2019

The minerals calcium carbonate and talc were filtered under various conditions of filtrate flow rate and suspension concentration, using constant rate conditions with the aid of a peristaltic pump to draw the filtrate. Cake concentrations of between 0.41 and 0.53 v/v for calcium carbonate and 0.19 and 0.26 v/v for talc were recorded. The mean sizes of the two different minerals were very similar, but the average specific resistances obtained from the experiments were 5.9 × 1010 and 7.4 × 1011 m/kg for calcium carbonate and talc, respectively. These results do not agree with what would be predicted from an analytical equation for permeability, such as Kozeny-Carman. In addition, discontinuities were observed in all cases on the curves of filtrate volume with time for the initial stage of filtration. This behaviour is attributed to retarded packing compressibility (RPC) complicating the analysis of the filter medium resistance. RPC is an important component in determining the filter cake resistance and its functionality with cake forming pressure. It is found that there are additional effects that enhance the resistance to permeation in different cake materials, which is not recognised in the standard analytical approaches. These complexities can be related to shape, polydispersity, or agglomeration within the material sample and not to the experimental equipment or procedure. Furthermore, a complete and straightforward methodology is presented in this work for investigating the significance, or otherwise, of medium resistance on the later stages of the filtration.
Ultrasound-Assisted Phytochemical Extraction Condition Optimization Using Response Surface Methodology from Perlette Grapes (Vitis vinifera)
Authors: Kaleem Muhammad , Ahmad Asif , Amir Rai Muhammad , Kaukab Raja Ghazala
Published: October 2019

In the current study, bioactive compounds of Vitis vinifera (Perlette) were extracted using an ultrasound-assisted extraction technique. The central composite design of response surface methodology (RSM) was used to determine the effect of time, temperature, and concentration of acetic acid on response variables that include extract yield, total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity of Vitis vinifera extracts. The results of the central composite design of RSM revealed that the quadratic polynomial model is best fitted to experimental results, with all the responses having a regression coefficient greater than 0.9. Optimized extraction levels include 26.5 min, an extraction temperature of 59 °C, and an acetic acid concentration of 62.9% with good extraction yield results of 34.95 g/100 g dry weight (DW) of grapes, TPC 34.38 mg gallic acid equivalent per gram (GAE/g) DW, flavonoid content 10.21 mg quercetin equivalents per gram (QEQ/g) DW, and antioxidant activity of 9.11 mg/100 mL ascorbic acid equivalent. The present study showed that acetic acid can be effectively used for the ultrasound-assisted extraction of polyphenols, flavonoids, and antioxidants of Vitis vinifera. These optimized conditions can be used for the extraction of bioactive compounds that can be for the development of nutraceutical products.
Interference Mitigation in Automotive Radars Using Pseudo-Random Cyclic Orthogonal Sequences
Authors: Skaria Sruthy , Al-Hourani Akram , J. Evans Robin , Sithamparanathan Kandeepan , Parampalli Udaya
Published: October 2019

The number of small sophisticated wireless sensors which share the electromagnetic spectrum is expected to grow rapidly over the next decade and interference between these sensors is anticipated to become a major challenge. In this paper we study the interference mechanisms in one such sensor, automotive radars, where our results are directly applicable to a range of other sensor situations. In particular, we study the impact of radar waveform design and the associated receiver processing on the statistics of radar–radar interference and its effects on sensing performance. We propose a novel interference mitigation approach based on pseudo-random cyclic orthogonal sequences (PRCOS), which enable sensors to rapidly learn the interference environment and avoid using frequency overlapping waveforms, which in turn results in a significant interference mitigation with analytically tractable statistical characterization. The performance of our new approach is benchmarked against the popular random stepped frequency waveform sequences (RSFWS), where both simulation and analytic results show considerable interference reduction. Furthermore, we perform experimental measurements on commercially available automotive radars to verify the proposed model and framework.
Design of a Phased Array EMAT for Inspection Applications in Liquid Sodium
Authors: Pucci Laura , Raillon Raphaële , Taupin Laura , Baqué François
Published: October 2019

This article describes the development of a French CEA in-house phased array Electro Magnetic Acoustic Transducer (EMAT) adapted to hot and opaque sodium environment for in-service inspection of Sodium Fast Reactors. The work presented herein aimed at improving in-service inspection techniques for the ASTRID reactor project. The design process of the phased array EMAT is explained and followed by a review of laboratory experimental test results.
Mechanical Design and Kinematic Modeling of a Cable-Driven Arm Exoskeleton Incorporating Inaccurate Human Limb Anthropomorphic Parameters
Authors: Chen Weihai , Li Zhongyi , Cui Xiang , Zhang Jianbin , Bai Shaoping
Published: October 2019

Compared with conventional exoskeletons with rigid links, cable-driven upper-limb exoskeletons are light weight and have simple structures. However, cable-driven exoskeletons rely heavily on the human skeletal system for support. Kinematic modeling and control thus becomes very challenging due to inaccurate anthropomorphic parameters and flexible attachments. In this paper, the mechanical design of a cable-driven arm rehabilitation exoskeleton is proposed to accommodate human limbs of different sizes and shapes. A novel arm cuff able to adapt to the contours of human upper limbs is designed. This has given rise to an exoskeleton which reduces the uncertainties caused by instabilities between the exoskeleton and the human arm. A kinematic model of the exoskeleton is further developed by considering the inaccuracies of human-arm skeleton kinematics and attachment errors of the exoskeleton. A parameter identification method is used to improve the accuracy of the kinematic model. The developed kinematic model is finally tested with a primary experiment with an exoskeleton prototype.
Constrained MLAMBDA Method for Multi-GNSS Structural Health Monitoring
Authors: Li Haiyang , Nie Guigen , Chen Dezhong , Wu Shuguang , Wang Kezhi
Published: October 2019

Deformation monitoring of engineering structures using the advanced Global Navigation Satellite System (GNSS) has attracted research interest due to its high-precision, constant availability and global coverage. However, GNSS application requires precise coordinates of points of interest through quick and reliable resolution of integer ambiguities in carrier phase measurements. Conventional integer ambiguity resolution algorithms have been extensively researched indeed in the past few decades, although the application of GNSS to structural health monitoring is still limited. In particular, known a priori information related to the structure of a body of interest is not normally considered. This study proposes a composite strategy that incorporates modified least-squares ambiguity decorrelation adjustment (MLAMBDA) method with priori information of the structural deformation. Data from the observation sites of Baishazhou Bridge are used to test method performance. Compared to MLAMBDA methods that do not consider priori information, the ambiguity success rate (ASR) improves by 20% for global navigation satellite system (GLONASS) and 10% for Multi-GNSS, while running time is reduced by 60 s for a single system and 180 s for Multi-GNSS system. Experimental results of Teaching Experiment Building indicate that our constrained MLAMBDA method improves positioning accuracy and meets the requirements of structural health monitoring, suggesting that the proposed strategy presents an improved integer ambiguity resolution algorithm.