bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibitor Kanal Kv1.3: Ekstrak Racun Kalajengking spesies Heterometrus spinnifer (HsTX1) sebagai Terapi Potensial Lupus Eritematosus Sistemik (LES)
Authors: Sigilipu Yitzchak Millenard , Nurazizah Namira Assyfa , Dewi Nararian Padma
Published: February 2022

Background: Systemic Lupus Erythematosus (SLE) is one of the most complex and common autoimmune disease. Current therapy is limited to symptomatic treatment which lead to disease relapse. The use of corticosteroids as immunosuppressant has many side effects. Long-term use of this drug can cause the occurrence of osteoporosis, which confers more risk since most of SLE patients are women. Animal venom is a potential substance for development of therapeutic modalities. One of  the example of successful animal venom usage in therapy is captopril as anti-hypertensive agent.
Objectives: exploring the potential of scorpion venom as therapeutic modality for LES.
Methods: Analysis and synthesis of articles in the form of research paper and reviews relevant with the keywords Kv 1.3 channel, Systemic Lupus Erythematosus (SLE), dan Scorpion Venom.
Discussion: Inhibition of Kv1.3 channel by the peptides of scorpion venom has given new hope for the treatment of autoimmune diseases one of which is SLE. The channel is involved in most of the lymphocyte activation.
Conclusion: The utilization of scorpion toxins, especially the species of Heterometrus spinnifer (HsTX1), is expected to enlighten future developments of SLE treatment.
Keywords: Heterometrus spinnifer, HsTX1, Kv1.3 channel, scorpion venom, Systemic Lupus Erythematosus (SLE)
 
Latar Belakang: Lupus Eritematosus Sistemik (LES) merupakan salah satu penyakit autoimun yang kompleks dan cukup sering ditemui. Terapi saat ini hanya sebatas pada pengobatan simtomatik dan bersifat sementara. Penggunaan kortikosteroid sebagai imunosupresan memiliki banyak efek samping. Penggunaan obat ini secara jangka panjang dapat menyebabkan terjadinya osteoporosis, terlebih LES umumnya diderita oleh wanita. Racun merupakan salah satu substansi yang potensial untuk digunakan sebagai modalitas terapi. Salah satu contoh keberhasilan pengolahannya adalah obat kaptopril yang berfungsi sebagai obat antihipertensi.
Tujuan: menggali potensi penggunaan racun kalajengking sebagai terapi LES.
Metode: Analisis dan sintesis dari artikel berupa research paper dan review yang relevan dengan kata kunci Kv 1.3 channel, Lupus Eritematosus Sistemik (LES), dan Scorpion Venom.
Pembahasan: Inhibisi kanal Kv1.3 oleh peptida racun kalajengking memiliki potensi sebagai terapi penyakit autoimun salah satunya adalah LES. Kanal tersebut terlibat dalam sebagian besar aktivasi sel limfosit.
Kesimpulan: Pemanfaatan kandungan racun kalajengking, khususnya spesies Heterometrus spinnifer (HsTX1), diharapkan dapat berkontribusi dalam pengembangan terapi LES di masa depan.
Kata Kunci: Heterometrus spinnifer, HsTX1, kanal Kv1.3, Lupus Eritematosus Sistemik (LES), racun kalajengking
Pengetahuan tentang Gejala dan Pencegahan COVID-19 di SMA Negeri 2 Plus Panyabungan
Authors: Pulungan Nanda Sri Wahyuni
Published: February 2022

Background: The emergence of COVID-19 pandemic s a big challenge in its socialization and prevention. The distribution of knowledge faces many obstacles, especially in rural areas. The traditional Mandailing culture still opposes modernization because it is thick with religious values, local wisdom, and occult things. Students of SMA Negeri 2 Plus Panyabungan can be educators and provide knowledge for families and communities, but must have a good level of knowledge in order to avoid spreading false information about COVID-19.  
Objectives: To describe the level of knowledge about symptoms and COVID-19 prevention at SMA Negeri 2 Plus Panyabungan.
Methods: This research is observational descriptive research with cross-sectional approach. Data was collected by giving an online questionnaire to all class XII students of SMA Negeri 2 Plus Panyabungan.The research sample was 129 students with total sampling technique.
Results: The results showed that the majority of students' knowledge level was good knowledge as many as 126 people (97.7%), followed by 3 people (2.3%) with sufficient knowledge and 0 people (0%) with less knowledge.
Conclusion: The level of knowledge about symptoms and prevention of COVID-19 for grade XII students at SMA Negeri 2 Plus Panyabungan is included in the category of good knowledge.
Keywords: COVID-19, knowledge, prevention
 
Latar Belakang: Munculnya pandemi COVID-19 ini menjadi tantangan besar dalam sosialisasi dan pencegahannya.  Pemerataan pengetahuan mengalami banyak kendala, terutama di daerah pedesaan. Adat budaya Mandailing masih menentang adanya modernisasi karena kental dengan nilai religius, kearifan lokal, dan hal gaib. Para siswa SMA Negeri 2 Plus Panyabungan bisa menjadi edukator dan memberi pengetahuan bagi keluarga dan masyarakat tetapi harus memiliki tingkat pengetahuan yang baik untuk menghindari tersebarnya informasi yang tidak benar mengenai COVID-19.
Tujuan: Mengetahui gambaran tingkat peengetahuan tentang gejala dan pencegahan COVID-19 di SMA Negeri 2 Plus Panyabungan.
Metode: Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross-sectional. Pengumpulan data dilakukan dengan cara memberikan kuesioner online kepada semua murid kelas XII SMA Negeri 2 Plus Panyabungan. Sampel penelitian adalah 129 murid dengan teknik total sampling.
Hasil: Hasil penelitian menunjukkan bahwa mayoritas tingkat pengetahuan murid berpengetahuan baik sebanyak 126 orang (97,7%), diikuti berpengetahuan cukup sebanyak 3 orang (2,3%) dan berpengetahuan kurang sebanyak 0 orang (0%).
Kesimpulan: Tingkat pengetahuan tentang gejala dan pencegahan COVID-19 siswa kelas XII di SMA Negeri 2 Plus Panyabungan termasuk dalam kategori berpengetahuan baik.
Kata Kunci: COVID-19, pencegahan, pengetahuan
Datenschutzrechtliche Rahmenbedingungen medizinischer Forschung: Vorgaben der EU-Datenschutz-Grundverordnung und national geltender Gesetze
Authors: Weichert Thilo
Published: February 2022

The European Data Protection Regulation applies since May 25th, 2018. It creates a uniform data protection legal framework within the EU. National and international medical research projects, regardless of whether they were started before or after the introduction of the GDPR, are obliged to follow this new regulation and implement it promptly. This raises various challenges for a large number of medical research projects. The University Medicine Greifswald commissioned this legal report, that was prepared by DIERKS+COMPANY. Two real-world research projects, the Baltic Fracture Competence Centre (BFCC) as well as the German Centre for Cardiovascular Research (DZHK) provide use cases, questions, and context for this legal report. It addresses questions regarding all steps of data processing. The report provides practical answers to a wide array of technical and organisational questions in the area of data protection-compliant processing of research data. A comprehensive guide to GDPR-compliant data processing has been developed, which both summarises the broad legal environment and provides specific assistance in the design and implementation of GDPR-compliant data management processes, including Informed Consent, Legal Consequences of Withdrawal, and Privacy by Design.
El papel del sistema financiero en la recuperación
Authors: Carbó Valverde Santiago
Published: February 2022

En este artículo se analiza el papel del sector bancario en la recuperación económica tras la pandemia. El protagonismo ha estado en los créditos a empresas, muchos de ellos con aval del Instituto de Crédito Oficial (ICO). El apoyo crediticio de la banca para la recuperación económica será un proceso altamente selectivo dada la delicada situación financiera de una parte importante del tejido empresarial.
Las empresas españolas en la pandemia: situación financiera y perspectivas de recuperación
Authors: Salas Fumás Vicente
Published: February 2022

Con datos de las Sociedades No Financieras (SNF) en España se analiza la pérdida de actividad empresarial durante la pandemia, y sus efectos sobre la liquidez, endeudamiento, beneficios e incentivos a la inversión. La pérdida de actividad reduce beneficios y recursos generados, pero sin afectar a la liquidez y capacidad de financiación del conjunto de las SNF porque se compensan con más endeudamiento, menos inversión en capital y menos dividendos pagados. La reducción en los márgenes empresariales puede tener un efecto negativo sobre los incentivos a invertir en la recuperación, pero el aumento en los gastos de personal en relación al valor añadido, que produce la reducción en el margen, podría actuar como estímulo por el lado de la demanda.
Macroeconomía, energía y emisiones de CO2
Authors: Díaz Antonia , Marrero Gustavo A. , Puch Luis A.
Published: February 2022

En este trabajo revisamos nuestros resultados recientes acerca del vínculo entre el desempeño macroeconómico, el mix de tecnologías energéticas y la evolución de las emisiones de CO2. El marco teórico del análisis es el de los modelos de crecimiento económico con generaciones sucesivas de capital. Mostramos que las emisiones de CO2 dependen, fundamentalmente, del crecimiento económico sostenido por altos niveles de intensidad energética fósil. Finalmente, reflexionamos sobre la posibilidad de avanzar simultáneamente en la transición verde y la recuperación económica tras el impacto de la COVID-19.
PENINGKATAN KEMAMPUAN BERBICARA BAHASA INGGRIS MELALUI STORYTELLING CERITA RAKYAT KEPADA MAHASISWA ALIYAH PONDOK PESANTREN DARUL MURSYIDI SIALOGO
Authors: Harahap Nursaima
Published: February 2022

Story telling is a way of learning that has been used since ancient times and has become a very important learning tool. The teacher tells a story or literary work through story telling and the students do too. Morrow explained that story telling is an activity is fun and stimulates the imagination of students. The reason of teams took this theme was very well known in the North Sumatera region, especially the Mandailing Natal community and story telling was a way of learning that has been used since ancient times and has become a very important learning tool. The teacher conveys a story or literacy work through storytelling and the students do likewise. In addition to make this learning not monotonous, the teacher making groping into several groups then teacher shares English text which contains the story of Sampuraga to each group and tells the students to underline what they know the meaning of as many as 20 words in a period of 15 minutes and the teacher monitors students’ activities. After that, each group wrote down the vocabulary and meanings on the whiteboard in turn so that the students could understand the contents of the story about sampuraga.
Meningkatkan Vocabulary Bahasa Inggris dengan Pelatihan Last Man Standing Games di Madrasah Aliyah Darul Mursyidi Sialogo Padangsidimpuan
Authors: Siregar Rini Kesuma
Published: February 2022

Abstrak

Games merupakan salah satu metode belajar yang paling banyak dipakai para guru ataupun dosen ketika mengajar didalam kelas khususnya bahasa inggris. Ada banyak sekali jenis games dalam bahasa inggris dan salah satunya adalah lastman standing karena dapat meningkatkan vocabulary siswa dalam belajar bahasa inggris. Permainan ini sendiri dilakukan secara berkelompok dan pemain yang bertahan paling akhir adalah pemenang pada permainan ini. Metode yang digunakan adalah metode ceramah, tanya jawab, penjelasan materi secara ucapan/ vocabulary, tanya jawab, dan praktek pengucapan vocabulary satu persatu. Adapun langkah – langkah pelaksanaan lastman standing adalah : 1) Peserta didik dibagi menjadi empat kelompok yang terdiri dari beberapa orang satu kelompok dengan laki – laki dan perempuan dibuat terpisah, 2) Membuat potongan gambar contoh vocabulary yang ditempel dipapan tulis, 3) Peserta yang telah dibuat dalam kelompok membuat permainan dengan menggilir benda seperti botol dengan cepat dari tangan yang satu ke tangan temannya yang lain secara bergiliran, bila ada perintah “stop” dari sipembuat games maka mereka akan berhenti sejenak dengan melihat ditangan siapa botol tsb berada, 4) Metode pembelajaran bahasa Inggris seperti games ini membuat mereka sangat bersemangat, riang dan antusias mengikutinya karena akan memotivasi mereka dalam memperkaya pengetahuan vocabulary dalam pembelajaran bahasa
PENGUATAN KAPASITAS BADAN USAHA MILIK DESA MOIN FE'U MELALUI PELATIHAN LITERASI FINANSIAL DI DESA FATUKANUTU KECAMATA AMABI OEFETO K
Authors: Manubulu Herry Aprilia , Rosari Renya
Published: February 2022

The existence of the Moin FE’U Bumdes has the aim of supporting the improvement of the welfare of the Fatukanutu village community and the Moin FE'U BUMDES can develop business units in utilizing the village's economic potential. Seeing the importance of the existence of BUMDES Moin Fe’U in an effort to improve the welfare of rural communities, the urgency of the need for service for BUMDES Moin FE'U is training to strengthen the capacity of village-owned enterprises through financial literacy training. Participants in this service are village officials and managers of BUMDES Moin Fe'U. The method of implementing the service is lecture,  discussions and training. The stages implementation are 1) delivery of material about bussines plan and financial reports, 2) discussions, 3) the practice of preparing financial reports. The result of this PKM is for village officials and managers of Bumdes Moin Fe'U can make a bussines plan proposal and  able to compile financial reports based on SAK ETAP.
PENGGUNAAN ALAT PERAGA MATEMATIKA “KUBUS-KUBUS SATUAN” UNTUK MENINGKATKAN KREATIVITAS GURU SEKOLAH DASAR
Authors: Deda Yohanis Ndapa , Disnawati Hermina , Missa Ando
Published: February 2022

Media pembelajaran seperti alat peraga matematika sangat berperan dalam memahamkan konsep matematika siswa sekolah dasar. Pembelajaran menggunakan alat peraga matematika juga memberikan kesempatan siswa untuk mengekresikan pengalaman belajar yang menyenangkan. Namun guru sekolah dasar masih kesulitan menggunakan alat peraga matematika, khususnya “kubus-kubus satuan” dalam pembelajaran matematika. Untuk mewujudkan pembelajaran matematika yang menyenangkan, maka salah satu cara adalah melalui pengabdian penggunaan alat peraga matematika agar guru mampu menggunakan alat peraga matematika kubus-kubus satuan dalam pembelajaran matematika. Tujuan pengabdian ini adalah untuk meningkatkan kreativitas guru Sekolah Dasar dalam mengimplementasikan alat peraga “kubus-kubus satuan” dalam pembelajaran di kelas. Pengabdian ini dilaksanakan pada guru mitra Sekolah dasar negeri di Kabupaten Timor tengah Utara. Metode yang digunakan dalam pengabdian ini adalah Metode Pelatihan dan Pendampingan. Metode pelatihan dilaksanakan secara daring melalui aplikasi zoom meeting, kemudian metode Pendampingan dilakukan secara offline kepada dua guru mitra dengan menerapkan protokol kesehatan. Hasil pengabdian menunjukkan bahwa keterampilan guru mitra dalam menggunakan alat peraga matematika kubus-kubus satuan dalam mengajar di kelas. Hal ini dapat dilihat dari pekerjaan guru pada saat pretest mencapai 63,6% dan pada posttest mencapai 80%.
University Campus Architects and Their Influences from the Perspective of Bibliometrics
Authors: Fan Jiayue , Chen Yile
Published: February 2022

With the development of high-tech, digital cities and other information means, higher education is an important part of modern talent training. The construction of higher education is also related to the university system, the construction of university campuses, and the connotation of university culture. Therefore, the construction of university campuses has long been an issue of academic concern. Therefore, the influence of university campus architects also provides a good environment for university campus construction and university culture and provides a new research direction for higher education campus architecture. This paper uses CiteSpace software and Web of Science visual analysis platform to conduct text mining and visual analysis of the existing literature in the international Web of Science academic database and plot the number of published papers, subject distribution, and frequent citations of "University Campus Architect Research". A knowledge graph of literature and research hotspots, research topics, and research trends. Combing the current research status of University Campus Architect, we hope to provide theoretical support for further research on improving higher education campus construction and the frontier dynamics of academic research.
Faktor yang Berhubungan dengan Pemanfaatan Antenatal Care (ANC) pada Masa Pandemi COVID-19 di Wilayah Kerja Puskesmas Tamamaung Kota Makassar
Authors: Firzia Alda , Muchlis Nurmiati , Amelia Andi Rizki
Published: February 2022

Dalam situasi pandemi Covid-19 ini, banyak pembatasan hampir ke semua layanan rutin termasuk pelayanan Antenatal Care (ANC). Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan pemanfaatan Antenatal Care (ANC) pada masa pandemi Covid-19 di Wilayah Kerja Puskesmas Tamamaung Kota Makassar. Jenis penelitian ini menggunakan kuantitatif dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah ibu yang memiliki bayi 0-6 bulan di Wilayah Kerja Puskesmas Tamamaung Kota Makassar. Teknik pengambilan sampel yaitu menggunakan metode purposive sampling dengan jumlah sampel sebanyak 68 Responden. Metode analisis data menggunakan uji univariat dan bivariat dengan uji chi-square dan Fisher’s Exact Test. Dari hasil penelitian diperoleh bahwa ada hubungan bermakna antara akses dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0.020 <0.05), ada hubungan bermakna antara sikap petugas kesehatan dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0,010 <0,05), ada hubungan bermakna antara  jarak kehamilan dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0.021 <0.05), ada hubungan bermakna antara nilai sosial budaya dengan pemanfaatan Antenatal Care (ANC) yaitu (p value = 0.012 <0.05) di Wilayah Kerja Puskesmas Tamamaung Kota Makassar. Adapun saran peneliti terkait penelitian ini ialah kepada petugas kesehatan lebih memperbanyak penyuluhan dalam meningkatkan pengetahuan ibu khususnya mengenai resiko jarak kehamilan yang sangat dekat, meningkatkan kepercayaan masyarakat tentang pemanfaatan Antenatal Care (ANC) serta petugas kesehatan sebaiknya tidak hanya dikunjungi melainkan petugas kesehatan juga mengunjungi masyarakat yang masih merasa tempat pelayanan Antenatal Care (ANC) sulit dijangkau.
Analisis Spasial Konsentrasi Logam Berat Timbal (Pb) pada Ikan di Kanal Kota Makassar
Authors: Vidyastuti Nur Hijrah , Syam Nasruddin , Abbas Hasriwiani Habo
Published: February 2022

Terkontaminasinya biota perairan seperti ikan oleh logam berat berupa timbal (Pb) dapat menyebabkan masalah terhadap kesehatan masyarakat yang mengonsumsi ikan yang terkontaminasi oleh logam berat. Adapun tujuan dari penelitian ini adalah untuk mengetahui konsentrasi logam berat timbal (Pb) pada ikan dan sedimen di Kanal Kota Makassar. Jenis penelitian ini adalah observasional dengan jenis rancangan exploratif dengan pendekatan analisis spasial Sistem Informasi Georafi (SIG)  konsentrasi logam berat timbal (Pb) pada ikan di kanal Kota Makassar. Hasil penelitian ini menunjukkan bahwa konsentrasi timbal (Pb) pada ikan di titik I yaitu 0.093 µg/gr, pada titik II yaitu 0.035 µg/gr dan pada titik III yaitu 0.033 µg/gr. Titik I merupakan titik yang berpotensi lebih tinggi terkontaminasi logam berat timbal (Pb).
Foros de discusión con pares externos a través de encuentros sincrónicos como actividad de aula
Authors: Solórzano Bernal Andrés
Published: February 2022

Las dinámicas de la docencia siempre han sido cambiantes, los modelos pedagógicos y sus didácticas suelen estar dirigidas a responder al contexto social y cultural de la época en la que se llevan a cabo y este año no fue la excepción. El reto generado por la inesperada migración de la presencialidad a la virtualidad fue una oportunidad para pensar y proponer nuevas dinámicas de clase para que los estudiantes mantuvieran su atención y su motivación en los procesos de aprendizaje inherentes a la asignatura de patología y semiología del segmento anterior ocular a través de una experiencia de intercambio sincrónico con un par externo experto en una temática determinada de clase que los contextualizó sobre el manejo actual de la enfermedad y donde mi labor fue fomentar una construcción de conocimiento y un desarrollo del pensamiento crítico en el estudiante.
Práctica pedagógica en pro del pensamiento crítico y habilidades tecnológicas y digitales
Authors: Mesa Suarez Edgar Alcibiades
Published: February 2022

Este artículo muestra las didácticas planteadas a los estudiantes de las asignaturas de contabilidad y banca y medios de pago, en el programa de Negocios Internacionales de la Fundación Universitaria del Área Andina. Su objetivo, plantear herramientas de análisis de problemas en la contabilidad aplicada y estructuración de un proyecto innovador en pro del pensamiento crítico, liderazgo colectivo y habilidades tecnológicas y digitales en los estudiantes.

Expone la matematización y cómo esta es relevante para el desempeño de los estudiantes en las asignaturas. Aclara el instrumento que se aplicó para validar los pre-saberes matemáticos. Especifica las didácticas planteadas. Argumenta la articulación con el modelo institucional y se resaltan los resultados obtenidos.

La práctica llevó al estudiante a validar sus competencias en el marco del evento académico shark investor, en el diseño, elaboración y aplicación de un modelo contable básico en Excel.
Prototipo ADEMO: práctica pedagógico-didáctica para administración de oxitocina, mediada por tecnología
Authors: Posada Morales María Neyfeth , Muñoz Astudillo María Nelcy
Published: February 2022

La administración de oxitocina para inducir el parto, requiere, enfermeros con conocimientos y experticia en farmacología, matemáticas básica y fisiología del embarazo. Además de práctica simulada ya que los estudiantes no pueden actuar directamente sobre el paciente por cuestiones de seguridad. Razón por la cual hay que garantizarles el desarrollo de habilidades y destrezas desde la academia, y aunque la simulación clínica ha demostrado ser efectiva, ha tenido inconvenientes por la necesidad de espacios físicos y costos.  Razones que llevaron al Grupo de Investigadores de Enfermería de Risaralda, a desarrollar un prototipo educativo ejecutable en la web, denominado “ADEMO”, que ha permitido a muchos estudiantes poner en práctica los conocimientos previos adquiridos sobre preparación y administración de oxitocina, sin límites de espacio y tiempo. Hoy 120 de ellos consideran que es un prototipo con diseño, contenido y navegabilidad adecuado para alcanzar ciertas competencias.
Storytelling como herramienta educativa
Authors: Naranjo Grisales Fernando de la Cruz , Rúas Amaya Yogel Alberto
Published: February 2022

Esta narración digital, a través del storytelling, es una estrategia educativa competente, así como un campo de estudio emergente en la instrucción o la enseñanza universitaria. A veces se ofrecen itinerarios en clases que apuntan a las historias en programas de comunicación y escritura creativa en algunas instituciones. Sin embargo, el potencial para esta narración digital se ensancha mucho más allá de los campos de las asignaturas transversales de comunicación y, obviamente, más lejos que en aquellas carreras que tienen que ver con los estudios de medios. De hecho, en muchos programas diferentes de la universidad, humanidades, administrativas, ingenierías, etc., la narración digital se ha utilizado con el fin de ayudar a nuestros estudiantes a prepararse en todo tipode contenidos y competencias de la universidad. Las aplicaciones de storytelling incluyen historias personales, anécdotas, conmemorativas, historias vocacionales y construcciones educativas, entre muchas otras de líneas similares. Este texto examina la práctica de la narración digital, de manera que destaca una pequeña gama de aplicaciones en la educación superior.
Amerika Birleşik Devletleri Emek Piyasası ve Osmanlı Göçmenleri: 1910 Amerikan Nüfus Kayıtları Üzerine Bir İnceleme
Authors: Hanedar Avni Önder , Yiğit Yunus , Gür Yiğit Fazilet İrem , Uysal Sezgin
Published: February 2022

Erken 20. yüzyılda Amerika Birleşik Devletleri muazzam ölçekli iktisadi büyümesi ile ciddi bir işgücü talebi yaratmış, iktisadi ve politik sorunlar içinde bulunan çevre ülkelerden büyük bir göçün hedefi haline gelmişti. Aynı dönemde Osmanlı İmparatorluğu, bünyesindeki farklı etnik gruplardan, örneğin, Arap, Ermeni veya Türk, birçok insanı Amerika Birleşik Devletleri’ne uğurlamıştı. Bu farklı etnik gruplara mensup göçmenlerin emek piyasasında hangi özellikleri ile kalıcı veya özümsenmiş olup olamadığı, niceliksel kanıtlarla yeterince tartışılmamıştır. Çalışma, 1910 Amerikan nüfus sayımına dayalı veriler ile farklı etnik kökenlere mensup Osmanlı göçmenlerinin Amerika Birleşik Devletleri emek piyasasında kalıcılıklarının zaman içerisinde ne şekilde değiştiğini incelemektedir. Niceliksel yöntemler ile elde edilen bulgular Amerika Birleşik Devletleri’ne daha erken göç eden grupların, Musevi ve Ermeni kökenli Osmanlı vatandaşlarının, yüksek gelir düzeylerine erişebildiklerini, dolayısıyla Türk, Arnavut gibi diğer gruplara göre kalıcılık konusunda daha az sorun yaşadıklarına işaret etmektedir.
Akhtar, Salman (2018). Göç ve Kimlik-Kargaşa Sağaltım ve Dönüşüm
Authors: Koçanlı Murat
Published: February 2022

Salman Akhtar, bu çalışmasında; insanlar neden diğer ülkelere göç ederler?, Göçün yarattığı ruhsal değişimler nelerdir?, Göçmen kendi ülkesinin kaybetmesinin yarattığı ruhsal değişimler nelerdir ve bunun yası yaşanabilir mi? Göçmen hastalarla yürütülen psikoterapilerde hangi değişkenlere dikkat edilmesi gerekir? gibi soruların cevaplarını aramıştır.
The Tetrapharmakos (Fourfold Cure) and the Sober Reasoning in Epicurus: A Critical Philosophical Paradigm against the Politicization of Medical Truth?
Authors: Markopoulou Αnna Ch.
Published: February 2022

In the present paper, we will discuss how the therapeutic effect of Epicurean philosophy as a pharmakon for human passions constitutes a critical philosophical paradigm against the politicization of medical truth. More specifically, we will argue that the concept of correcting habits of thought, which confers a philosophical meaning on the Greek word pharmakon, constructs a dialectical relationship of unity between nature and man. Then we will show that this conception is in contrast to the traditional meaning of pharmakon as an artificial means of therapy, which is ideologicalised in the politicization of medical truth, since it presupposes a technocratic conception leading to a dualism between superior technology, which rules, and inferior human nature, which is ruled. We will argue that establishing an enhancement of human nature as it ensues from the Epicurean ethics of the tetrapharmakos constitutes a critical philosophical paradigm against the politicization of medical truth.
Introduction
Authors: Tuncel Yunus
Published: February 2022

On behalf of myself and the editors for this debut edition, Yunus Tuncel and Francesca Ferrando, we are most pleased to offer the first issue of the Journal of the World Posthuman Society, 'Infinity: A Journal for Posthumanists'. The papers collected here were presented at the 24th World Congress of Philosophy held in Beijing in 2018. Paper are drawn from Roundtables and Workshops organized to accommodate the surging interest in Posthumanism.  The reader may accept my assurance that within these pages is contained some of the most avant garde thinking in this bourgeoning movement in philosophy.
Reinterpreting the meaning of Human in the Global Era following Levinas
Authors: Saha Debika
Published: February 2022

It is high time to explore the meaning of being human in this globalized world. While exploring the meaning of being human or relearning to be human in global times, this paper will try to interpret how to sustain our cultural identities in this democratic, technologically overpowered world. In between the divinization of the human as the centre of the world and her rejection by anti-humanism lies a third paradigm, explored by Emmanuel Levinas. We can relearn our position of being human from a new perspective that allows us to keep our uniqueness in terms of culture and values as individuals and to protect our cultural identities.
Understanding Twice-exceptionality (2e): A Multi-systems Perspective
Authors: Lim Lin
Published: February 2022

Although research and interests in twice-exceptionality (2e) have been increasing in the last few decades, most studies have focused on the definition, identification, and academic achievement in twice-exceptional students. Such focus can be understandable due to varying definitions, research operationalizations, and the lack of a typical twice-exceptional profile (Lee & Ritchotte, 2018; Wellisch & Brown, 2013). There is considerably less research focused on cognitive characteristics and least research focused on investigating non-cognitive factors influencing twice-exceptional performance and development (Beckmann & Minnaert, 2018). This paper serves to summarize factors that have been found to impact twice-exceptional, organized through a multi-systems (e.g., interpersonal, intrapersonal, contextual/situational, sociocultural, and socio-economical) approach, starting from individual variables to larger and more distal systems.
Prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency among Malaria Patients in Southern Thailand: 8 Years Retrospective Study
Authors: Khammanee Thunchanok , Sawangjaroen Nongyao , Buncherd Hansuk , Tun Aung Win , Thanapongpichat Supinya
Published: February 2022

Erythrocytes deficient in glucose-6-phosphate dehydrogenase (G6PD) is more susceptible to oxidative damage from free radical derived compounds. The hemolysis triggered by oxidative agents such as primaquine (PQ) is used for the radical treatment of hypnozoites of P. vivax. Testing of G6PD screening before malaria treatment is not a common practice in Thailand, which poses patients at risk of hemolysis. This retrospective study aimed to investigate the prevalence of G6PD in malaria patients who live in Southern Thailand. Eight hundred eighty-one malaria patients were collected for 8-year from 2012 to 2019, including 785 (89.1%) of P. vivax, 61 (6.9%) of P. falciparum, 27 (3.1%) of P. knowlesi, and 8 (0.9%) of mixed infections. The DiaPlexC genotyping kit (Asian type) and PCR-RFLP were employed to determine the G6PD variants. The result showed that 5 different types of G6PD variants were identified in 26 cases (2.9%); 12/26 (46.2%) had Mahidol (487G>A) and 11/26 (42.3%) had Viangchan (871G>A) variants, while the rest had Kaiping (1388G>A), Union (1360C>T), and Mediterranean (563C>T) variants. G6PD Songklanagarind (196T>A) variant was not found in the study. Our result did not show a significant difference in the malaria parasite densities in patients between G6PD-deficient and G6PD-normal groups. According to our findings, testing G6PD deficiency and monitoring the potential PQ toxicity in patients who receive PQ are highly recommended.
Pengolahan buah salak Bangkalan untuk mengembangkan potensi lokal
Authors: Kamalia Putri Ulfa , Rochmawati Rochmawati , Novitasari Adin , Imansari Febrina Iqhyanul , Hariyanti Mila
Published: February 2022

Salak merupakan ikon Kabupaten Bangkalan. Untuk mempromosikan buah salak sebagai potensi lokal daerah, kami mengadakan pelatihan pengolahan buah salak untuk para ibu rumah tangga muda agar mereka memiliki keterampilan dan mampu untuk membuka usaha olahan buah salak. Metode pelaksanaan kegiatan dilakukan melalui beberapa tahap yaitu: 1) Tahap sosialisasi kepada masyarakat; 2) Tahap perolehan bahan dan alat; 3) Tahap pelatihan; 4) Tahap pendampingan serta 5) Tahap evaluasi program. Hasil yang telah dicapai sesuai dengan luaran yang ditargetkan yaitu peningkatan keterampilan pengolahan buah salak pada kelompok sasaran. Produk olahan yang dihasilkan berupa donat salak, es krim salak, brownies salak, dan kaligrafi dari kulit salak. Potensi keberlanjutan dari kegiatan ini adalah terbentuknya sentra usaha produk olahan buah salak Bangkalan sehingga bisa menjadi oleh-oleh khas Bangkalan yang diminati wisatawan
Pengembangan instrumen supervisi akademik dalam penerapan pembelajaran berdiferensiasi
Authors: Hariyati Nunuk , Karwanto Karwanto , Khamidi Amrozi , Rifqi Ainur
Published: February 2022

Kebijakan Merdeka Belajar digulirkan Kementerian Pendidikan dan Kebudayaan sebagai wujud transformasi pengelolaan pendidikan yang menempatkan well-being peserta didik sebagai orientasi utama dalam kegiatan pembelajaran. Pembelajaran berdiferensiasi menjadi alternatif model pembelajaran yang mampu mewujudkan well-being bagi peserta didik. Sebagai seorang supervisor, Kepala Sekolah berperan penting dalam meningkatkan kualitas pembelajaran melalui kegiatan supervisi akademik. Pengembangan instrumen supervisi akademik yang mengarah pada pembelajaran berdiferensiasi menjadi salah satu upaya penting yang dapat mewujudkan well-being peserta didik sekaligus mendukung Kebijakan Merdeka Belajar. Analisis situasi di Kabupaten Nganjuk menghasilkan informasi: (1) pembelajaran berdiferensiasi belum diketahui secara detail oleh guru, (2) instrumen supervisi akademik dalam pembelajaran berdiferensiasi belum dikembangkan oleh kepala sekolah. Sehingga tujuan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan dan mengembangkan instrumen supervisi dalam pembelajaran berdiferensiasi. Metode pelatihan yaitu melalui pendekatan ekspositori, pembimbingan, penugasan dan FGD (Focus Group Discussion) yang diikuti 54 Kepala Sekolah yang tergabung dalam MKKS.  Hasil penelitian menunjukkan bahwa terjadi peningkatan rata-rata pro-test terhadap pre-test yaitu sebesar 20%. Selain itu penugasan terhadap kepala sekolah menjadi sangat efektif dalam meningkatkan keterampilan menyusun instrumen supervisi akademik dalam penerapan pembelajaran berdiferensiasi
Environmental correlates of elasmobranch and large fish distribution in a river-dominated estuary
Authors: Hamilton BR , Peterson CT , Dawdy A , Grubbs RD
Published: February 2022

Coastal areas serve as vital habitat for many marine fishes and often host broad gradients of environmental conditions that result in diverse species assemblages. Understanding the influence of environmental variables on the distribution and abundance of fishes is especially important for devising appropriate management strategies. We documented large fish community structure in the Apalachicola Bay system from 2018 to 2021 using fishery-independent longline and gillnet surveys. Spatiotemporal variation in fish assemblages was evaluated with permutational multivariate ANOVA, while community- and species-level habitat relationships were described across gradients of environmental variables with non-metric multidimensional scaling and generalized additive models. We captured 5085 fishes from 17 elasmobranch and 33 bony fish species, with gafftopsail catfish Bagre marinus, blacktip shark Carcharhinus limbatus, Atlantic sharpnose shark Rhizoprionodon terraenovae, and hardhead catfish Ariopsis felis comprising 82.1% of the total catch. Fish communities varied spatially throughout the system, and changes in these communities were most strongly correlated with gradients in salinity, clarity, and depth. We documented higher species richness and density of young elasmobranchs in our surveys compared to adjacent systems, supporting past suggestions that this area serves as important juvenile shark habitat. We suggest that flow from the Apalachicola River, transporting nutrients to the system and supporting numerous environmental niches across spatiotemporal scales, plays an influential role in maintaining the elevated diversity and density of elasmobranchs observed in this study.
Altruısm and Ratıonalıty Wıthın the Framework of Behavıoral Economıcs1
Authors: DOĞAN Assoc. Dr. Burhan , DOĞAN Res. Asst. Ezgi
Published: February 2022

In this study, behavioral economics and as one of the research topics of this new field, what altruism is, its types, psychological or environmental reasons, the contradictions of rational human and altruism, one of the basic assumptions of economics, were examined. A survey form was created to obtain data during the research process. While the distribution and variability criteria were used in the interpretation of the findings obtained from the research, Microsoft Excel and SPSS programs were used in the analysis and arrangement of the data. When the data is evaluated, individuals move away from rational behaviors due to the element of altruism, and limited rationality emerges. While the individual tries to be rational in many aspects; Due to empathy, happiness, ethical norms, and religious values, they may move away from rationality depending on the development of altruism. Therefore, based on this study, we can assume that individuals exhibit limited rational behaviors. Transferring the science of economics with the theoretical background from a mathematical point of view makes it difficult to be applicable, observable, and interpretable in real life. It will not be sufficient and correct to evaluate economics, which is not a new science, with rational choices and models only within the framework of the neoclassical economics approach. For economics, both mathematical methods and psychology should be means, not aim. Behavioral economics, which has become very popular in recent years, examines the common denominator of human economic preferences, decision-making processes, and the basic assumption of neoclassical economics, how rational people can be in real life, with the combination of economics and psychology.
Crimes of neocolonialism in modern Palestine: land and freedom
Authors: Georgoulas Stratos
Published: February 2022

Based on a field visit. I aim to explore aspects of “crimes of neocolonialism” in modern Palestine from the mid-20th century till the present. Oppression, displacement, and colonization take place mainly through land confiscation and denial of use and access, and (Israeli) state suppression and criminalization are a usual answer to Palestinian resistance. Using a personal narrative too, I will try to present the mechanisms, uncover their consequences of the above and connect with concepts such as neocolonialism, war crimes, and crimes against humanity.
Penerapan Relaksasi Nafas Dalam Untuk Menurunkan Ansietas Pada Ibu Hamil Trimester III Dimasa Pandemi COVID-19
Authors: Yuliyati Anggi Novita Dwi , Prasetyorini Heny
Published: February 2022

Pregnancy is a time of joy and anticipation. However, it can become anxiety and become a concern. Common problems experienced by women during pregnancy are anxiety and stress. Third trimester of pregnancy is the period of the last three months or the last third of the gestation period. The third trimester is the gestation period from the seventh to the ninth month (28-40 weeks). The gestation period starts from conception to the birth of the fetus. Normal length of pregnancy is 280 days (40 weeks or 9 months 7 days) calculated from the first day of the last menstruation. Anxiety (anxiety/anxiety) is a natural feeling disorder characterized by feelings of fear or worry that are deep and ongoing, do not experience disturbances in assessing reality, personality is still intact (no splitting of personality), behavior can be disrupted but is still in progress. normal limits. One of the management actions to reduce anxiety is deep breathing relaxation therapy. The purpose of this case study is to reduce anxiety in third trimester pregnant women during the COVID-19 pandemic. The case study method is in the form of a one grub pretest posttest design. The subjects of this study were 2 patients with third trimester pregnant women. The results of the study showed that there was a change in the level of anxiety from mild anxiety to no anxiety after being given the Deep Breathing Relaxation intervention for 3 days so it is hoped that the patient and the patient's family can take Deep Breathing Relaxation to reduce anxiety levels in third trimester pregnant women.
Swyer-James (Macleod) Sendromu: Bir olgu nedeniyle
Authors: ÇOLAK Mustafa , SARIOĞLU Nurhan
Published: February 2022

Swyer-James-MacLeod Sendromu (SJMS) etkilenen taraftaki pulmoner arterin hipoplazisine bağlı olarak hiperlüsen akciğer görünümü ile ayırt edilen nadir görülen bir hastalıktır. Çocuklukta geçirilen viral bronşiolit ve pnömonilere sekonder geliştiği düşünülmektedir. Elli dokuz yaşında bayan hasta eforla nefes darlığı, göğüste baskı hissi ve balgam yakınmaları ile başvurdu. Fizik muayanesinde solunum sesleri olağan idi. Posteroanterior (PA) akciğer grafisinde sol hemitoraksta belirgin hiperlüsensi ve hacim kaybı görüldü. Toraks bilgisayarlı tomografide sol pulmoner arter ve dallarının kalibrasyonunda sağa oranla belirgin derecede azalma ile aynı taraflı hiperlüsensi, sol akciğer alt lobda belirgin volüm kaybı ile bronşiektazi alanları gözlendi. Perfüzyon sintigrafisinde sol akciğer alt lobun hemen tamamı ile linguler segmentte büyük segmental perfüzyon defektleri izlenirken, ventilasyon sintigrafisinde bu alanlarda ventilasyon defektleri izlendi. Hastaya mevcut bulgularla SJMS tanısı konuldu. Hastalığın tedavisi çoğu vakada konservatiftir. Hastaların enfeksiyonlara karşı korunması, grip ve pnömokok aşılarının yaptırmaları önerilir. Olgumuzu tek taraflı hiperlüsen akciğer görünümü saptandığında bu sendromun ayırıcı tanılar arasında olması gerekliliğini vurgulamak amaçlı sunuyoruz.
Hip-Preserved Reconstruction Using a Customized Cementless Intercalary Endoprosthesis With an Intra-Neck Curved Stem in Patients With an Ultrashort Proximal Femur: Midterm Follow-Up Outcomes
Authors: You Qi , Lu Minxun , Min Li , Zhang Yuqi , Wang Jie , Wang Yitian , Zheng Chuanxi , Zhou Yong , Tu Chongqi
Published: February 2022

Background: Hemiarthroplasty is widely used for proximal femoral reconstruction after tumor resection. However, complications of hemiarthroplasty include infection, hip dislocation, and acetabular wear. This study aimed to: (1) evaluate the reliability and validity of a customized cementless intercalary endoprosthesis (CCIE) with an intra-neck curved stem (INCS) to reconstruct femoral diaphyseal defects with an ultrashort proximal femur (UPF); (2) assess the lower extremity function after reconstruction with this endoprosthesis; and (3) identify the postoperative complications associated with the use of this endoprosthesis.

Methods: Between October 2015 and May 2019, 13 patients underwent reconstruction with a CCIE with an INCS. The distance from the center of the femoral head to the midline of the body and the apex of the acetabulum was measured preoperatively. Additionally, the distance from the tip of the INCS to the midline of the body and the apex of the acetabulum was measured postoperatively. The femoral neck–shaft angle was also measured pre- and postoperatively. After an average follow-up duration of 46 months, the radiological outcomes of the CCIE with an INCS were analyzed. Function was evaluated with the Musculoskeletal Tumor Society (MSTS) score. Pain was measured using a paper visual analog scale (VAS) pre- and postoperatively, and complications were recorded.

Results: Compared with our preoperative design, we found no significant difference in the postoperative distance from the tip of the INCS to the body midline (p = 0.187) and the apex of the acetabulum (p = 0.159), or in the postoperative femoral neck–shaft angle (p = 0.793). Thus, the INCS positions were deemed accurate. The average MSTS score was 26 (range: 24–28), and the VAS score was significantly decreased postoperatively compared with preoperatively (p < 0.0001). No patients developed aseptic loosening, infection, periprosthetic fracture, or prosthetic fracture as of the last follow-up.

Conclusion: The CCIE with an INCS was a valid and reliable method for reconstructing femoral diaphyseal defects with a UPF following malignant tumor resection. Postoperative lower extremity function was acceptable, with an appropriate individualized rehabilitation program, and the incidence of complications was low.
Changes in Physiological Tendon Substrate Stiffness Have Moderate Effects on Tendon-Derived Cell Growth and Immune Cell Activation
Authors: Konar Subhajit , Bolam Scott M. , Coleman Brendan , Dalbeth Nicola , McGlashan Sue R. , Leung Sophia , Cornish Jillian , Naot Dorit , Musson David S.
Published: February 2022

Tendinopathy is characterised by pathological changes in tendon matrix composition, architecture, and stiffness, alterations in tendon resident cell characteristics, and fibrosis, with inflammation also emerging as an important factor in tendinopathy progression. The sequence of pathological changes in tendinopathy and the cellular effects of the deteriorating matrix are largely unknown. This study investigated the effects of substrate stiffness on tendon-derived cells (TDCs) and THP-1 macrophages using PDMS substrates representing physiological tendon stiffness (1.88 MPa), a stiff gel (3.17 MPa) and a soft gel (0.61 MPa). Human TDCs were cultured on the different gel substrates and on tissue culture plastic. Cell growth was determined by alamarBlue™ assay, cell morphology was analysed in f-actin labelled cells, and phenotypic markers were analysed by real-time PCR. We found that in comparison to TDCs growing on gels with physiological stiffness, cell growth increased on soft gels at 48 h (23%, p = 0.003). Cell morphology was similar on all three gels. SCX expression was slightly reduced on the soft gels (1.4-fold lower, p = 0.026) and COL1A1 expression increased on the stiff gels (2.2-fold, p = 0.041). Culturing THP-1 macrophages on soft gels induced increased expression of IL1B (2-fold, p = 0.018), and IL8 expression was inhibited on the stiffer gels (1.9-fold, p = 0.012). We also found that culturing TDCs on plastic increased cell growth, altered cell morphology, and inhibited the expression of SCX, SOX9, MMP3, and COL3. We conclude that TDCs and macrophages respond to changes in matrix stiffness. The magnitude of responses measured in TDCs were minor on the range of substrate stiffness tested by the gels. Changes in THP-1 macrophages suggested a more inflammatory phenotype on substrates with non-physiological stiffness. Although cell response to subtle variations in matrix stiffness was moderate, it is possible that these alterations may contribute to the onset and progression of tendinopathy.