bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da inferência do tratamento manipulativo osteopático sobre a frequência cardíaca em recém-nascidos em uma ala materno infantil: ensaio clínico randomizado
Authors: Camilo Josivaldo de Mendonça , Vilagra José Mohamud , Vieira Lizyana , Taglietti Marcelo , Grando Felipe , Abico Ricardo Massao , Abico Sergio Toshiro , Tori Fernanda da Silva , Barros Rebeka Crislaynne Timóteo de Carvalho Silva , Cagnini Thaynara Larissa
Published: February 2022

Verificar a inferência do Tratamento Manipulativo Osteopático sobre a frequência cardíaca em recém-nascidos a termo internados em uma ala materno infantil. Trata-se de um estudo quali-quantitativo, longitudinal, do tipo ensaio clínico randomizado, realizado no Hospital Universitário do município de Cascavel, Paraná, Brasil. Esse estudo foi submetido e aprovado em 2021 pelo Comitê de Ética em Pesquisa, respeitando a resolução 466/12. Os dados provenientes dos instrumentos foram tabulados no Microsoft Office Excel® e exportados para o programa SPSS, versão 20.0. Foram analisados 70 neonatos a termo e alocados de modo aleatório em três grupos, sendo que o G1 a intervenção foi o Toque estático, o G2 foi o protocolo osteopático Craniossacral, e o G3 foi o Tratamento Manipulativo Osteopático. Os resultados desta pesquisa demonstraram que o Toque estático não produziu alteração significativa na FC dos recém-nascidos. O protocolo osteopático craniossacral e o TMO mostraram uma tendência na redução da FC, sendo que a valoração tende a retornar aos padrões iniciais após 10 minutos da intervenção e após 24 horas respectivamente, sugerindo que uma única intervenção osteopática pode induzir a efeitos benéficos na FC de recém-nascidos a termo.
Enfermagem no diagnóstico da Síndrome HELLP na Atenção Básica
Authors: Couto Sabrina Iracema da Silva , Pacheco Isabella Cristina Oliveira , Santos Agda Renata Barros , Silva Raquel Maria da , Lima Maria da Conceição Ferreira de , Silva Priscila de Oliveira , Lima Andreia Gomes de , Silva Melriziane Barboza da , Maia Gabriela Santos , Morais Carlla Dannyelly Pereira , Cardoso Fabiana Silva Cruz , Lopes Laryssa Grazielle Feitosa
Published: February 2022

Objetivo: Apresentar com base na literatura científica o diagnóstico da Síndrome HELLP na Atenção Básica e como a enfermagem está inserida nesse contexto. Metodologia: Trata-se de uma revisão integrativa da literatura, realizada nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SCIELO), Banco de Dados em Enfermagem (BDENF) e Google Scholar, foram utilizados artigos publicados no período entre 2018 e 2022 e escritos na língua portuguesa. Resultados: Foram encontrados 1.036 artigos no total, após aplicação dos critérios de inclusão e exclusão, foram selecionados 11 artigos, sendo 1 artigos na LILACS, 0 na SCIELO, 2 na BDENF e 8 no Google Acadêmico, após criteriosa dos resultados a seleção das informações foi feita de forma descritiva e predispôs a etapa de extração dos dados: autor / ano de publicação, título / base de dados e objetivo geral. Conclusão: Portanto, em conformidade com os achados na literatura, a Síndrome HELLP representa um grave problema na gestação principalmente por estar associada a pré-eclâmpsia e eclâmpsia, que juntas as três são complicações que acarretam em risco para mãe e bebê. Onde percebe-se que o enfermeiro da atenção básica possui grande responsabilidade no diagnostico dessa síndrome, sendo fundamental ter conhecimento da mesma e saber como agir.
Construção de instrumento guia para pesquisa com populações amazônicas a partir das determinações sociais em saúde
Authors: Nascimento Monique Teresa Amoras do , Araújo Jainara de Souza , Silva Brenda Caroline Martins da , Castro Nádile Juliane Costa de
Published: February 2022

Objetivo: Relatar experiência da construção de instrumento guia para pesquisa de campo com populações Amazônicas. Método: Relato de experiência do tipo descritivo realizado a partir do método Blended Learning. Foi realizada entre agosto de 2020 a julho de 2021 por meio de atividades de um Grupo de Estudo e Pesquisa e um projeto de pesquisa da Faculdade de Enfermagem da Universidade Federal do Pará durante o período Remoto Emergencial. Participaram da experiência três discentes e um docente. Resultado: Desenvolveu-se o instrumento-guia por meio do ensino-aprendizagem da saúde das populações em situação de vulnerabilidade no contexto amazônico a partir de treinamento sobre pesquisa na Amazônia, modo de vida de populações ribeirinhas, conceitos sobre questões socioambientais e determinações em saúde e das Políticas Públicas de Saúde. Considerações Finais: A formação de pesquisadores para pesquisa no contexto amazônico deve ser realizada por meio de treinamentos que promovam o pensamento crítico a partir da realidade regional, com instrumentos implementados a partir das políticas públicas de saúde para populações do campo, águas e florestas, assim como da atenção à saúde e dos serviços direcionados às populações ribeirinhas.
EFFECT OF PSAK 72 IMPLEMENTATION IN PROPERTY AND REAL ESTATE’S FINANCIAL HEALTH
Authors:   Sekolah Tinggi Manajemen PPM Indonesia, Fransisca Juni , Ahalik Ahalik ,   Sekolah Tinggi Manajemen PPM Indonesia
Published: February 2022

PSAK 72 is set to become a single standard regulating revenue recognition and is effective starting January 1st, 2020. This standard has a significant impact on the property and real estate sectors. This study aims to compare the company's financial health before and after the application of PSAK 72 using the Springate and Taffler models. The ratios used to measure the comparison of income in this study are net profit margin and total asset turnover. The population used in the companiy's property and real estate listed on the Indonesia Stock Exchange in 2019-2020. By using a purposive sampling method, the research sample obtained 31 companies. The analytical tool used in this test is the Wilcoxon signed-rank test. The results showed a significant decrease in net profit margin and total asset turnover between before and after the implementation of PSAK 72 and the effect on financial health as measured by the Springate and Taffler models.
Characteristics of Articles Published in Different Quartiles: A Bibliometric Analysis of Sport and Exercise Psychology Journals
Authors: Taş Hakan , Mikhaylova Alena , Ödemiş Hasan , Uçar Eylül Çisem , Söğüt Mustafa
Published: February 2022

Background. The purposes of this study were to determine the quantitative characteristics of the articles published in sports and exercise psychology journals in four quartiles of Web of Science and to understand whether these characteristics had any effect on citation.

Methods. Sport and exercise psychology journals indexed under the Sport Sciences subject category were included in the study. A total of 172 articles published in 2017, which was the most recent date meeting inclusion criteria, were collected from four sport and exercise psychology journals included: Psychology of Sport and Exercise (Q1), Journal of Sport and Exercise Psychology (Q2), Sport Psychologist (Q3), and International Journal of Sport Psychology (Q4).

Results. The articles published in Q1 journal were multi-institutional and multinational. Besides, they had longer abstracts and discussions and cited more references. The results revealed that multinational articles and articles with structured abstracts had higher citations than single country articles and articles with unstructured abstracts. The number of affiliated countries and references, and longer titles, abstracts, and introductions were found significantly associated with the number of citations. The bibliometric analysis indicated that the UK, the USA, and Canada were the major contributing countries.

Conclusion. This study is the first attempt to investigate the characteristics of articles published in different WoS quartiles within the field of sports and exercise psychology. The findings of the study may help researchers to improve their citation count.

Keywords: scientific productivity, essential science indicators, journal impact factor, Web of Science, scientometrics.
Bad History: The Controversy over Henry Dundas and the Historiography of the Abolition of the Slave Trade
Authors: McCarthy Angela
Published: February 2022

How far do individuals determine events and how much agency do they have? In March 2021, Edinburgh City Council approved plans to install a new plaque on the Melville monument in Edinburgh, Scotland, part of which refers to ‘the more than half-a-million Africans whose enslavement was a consequence of Henry Dundas’s actions’. These words on the plaque serve to hold Dundas (later Lord Melville) solely accountable for the consequences of a parliamentary vote taken in the House of Commons in 1792 on the gradual delay of the British slave trade. This article interrogates the historical controversy surrounding Henry Dundas’s role in abolition of the British slave trade with a focus on two main areas. First, it contradicts claims that historians unequivocally agree that Dundas delayed abolition. Second, it explores arguments that Dundas’s mobilisation of Scottish votes and oratorical skills ensured continuation of the slave trade. The article argues that historical realities were much more nuanced and complex in the slave trade abolition debates than a focus on the role and significance of one politician suggests. Edinburgh City Council therefore have the urgent moral duty to remove the plaque. Otherwise, the city faces the grave charge and international opprobrium of falsifying history on a public monument.
PENGARUH KOMITMEN PROFESIONAL TERHADAP KEPUASAN KERJA AUDITOR PADA BADAN PEMERIKSA KEUANGAN RI PERWAKILAN PROVINSI SULAWESI TENGGARA
Authors: Arifuddin Arifuddin , Tamburaka Sulvariany , Sari Nurlina
Published: February 2022

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh komitmen profesional terhadap kepuasan kerja auditor di BPK (Badan Pemeriksa Keuangan) RI Perwakilan Sulawesi Tenggara. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif dan kuantitatif. Teknik sampel yang digunakan dalam penelitian ini adalah sampling jenuh, dimana sampel dalam penelitian ini merupakan auditor pada BPK (Badan Pemeriksa Keuangan) RI Perwakilan Sulawesi Tenggara sebanyak 27 orang. Instrumen penelitian menggunakan kuesioner, sedangkan alat analisis yang digunakan adalah analisis regresi linear sederhana. Hasil penelitian ini menunjukkan Koefisien regresi bernilai positif, sehingga dapat dikatakan bahwa komitmen profesional (variabel X) terhadap kepuasan kerja auditor (variabel Y) berpengaruh signifikan.
PENGARUH KOMPETENSI DAN MOTIVASI KERJA TERHADAP KUALITAS LAPORAN KEUANGAN (Studi Pada Badan Keuangan dan Aset Daerah Kabupaten Muna)
Authors: Mustafa Santiadji , Hasbudin Hasbudin , Halmatinus Halmatinus
Published: February 2022

Penelitian ini bertujuan untuk menguji pengaruh kompetensi dan motivasi kerja terhadap kualitas laporan keuangan. Pengumpulan data dilakukan dengan cara menyebarkan kuesioner kepada pegawai pada Badan Keuangan dan Aset Daerah Kabupaten Muna yang terdiri dari 20 responden. Teknik pengambilan sampel menggunakan metode purposive sampling. Metode analisis yang digunakan adalah analisis deskriptif dan analisis regresi linear berganda.Hasil penelitian ini menunjukan bahwa variabel kompetensi dan motivasi kerja secara parsial berpengaruh positif dan signifikan terhadap kualitas laporan keuangan pada BKAD Kabupaten Muna. Sedangkan koefisien determinasi menunjukkan hasil bahwa secara simultan pengaruh yang diberikan variabel kompetensi dan motivasi kerja terhadap kualitas laporan keuangan sebesar 58% dan sisanya sebesar 42% yang dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.
ANALISIS VALUE FOR MONEY PADA KINERJA DINAS CIPTA KARYA, BINA KONSTRUKSI DAN TATA RUANG PROVINSI SULAWESI TENGGARA
Authors: Akib Mulyati , Safaruddin Safaruddin , Febriyanti Zakinah Sri
Published: February 2022

Penelitian ini bertujuan untuk mengetahui kinerja value for money pada DinasCipta Karya, Bina Konstruksi dan Tata Ruang Provinsi Sulawesi Tenggara. Data yangdigunakan adalah data primer dan sekunder dengan metode pengumpulan data dalampenelitian ini yaitu wawancara dan dokumentasi. Analisis data yang digunakan adalahanalisis deskriptif. Hasil penelitian ini menunjukan bahwa kinerja value for money padaDinas Cipta Karya, Bina Konstruksi dan Tata Ruang Provinsi Sulawesi Tenggaraditinjau dari tahun 2017-2019, dinilai sudah ekonomis dan efisien dilihat dari susunananggaran yang telah dilaksanakan dengan baik, karena belanja yang direalisasikan lebihsedikit dibandingkan dengan apa yang dianggarkan, dimana dari unsur anggaran belanjatersebut yang memberikan konstribusi paling banyak yaitu belanja langsung yang terdiridari belanja barang dan jasa, belanja pegawai dan belanja modal. Namun pada rasioefektivitas dinilai tidak efektif, karena adanya program/kegiatan yang tidakterlaksanakan.
PENGARUH SUMBER DAYA MANUSIA DAN SISTEM PENGENDALIAN INTERN TERHADAP KUALITAS INFORMASI LAPORAN KEUANGAN PEMERINTAH DAERAH DI KABUPATEN MUNA BARAT
Authors: Intihanah Intihanah , Arifuddin Arifuddin , Faisal Faisal
Published: February 2022

Penelitian bertujuan untuk menguji dan menjelaskan pengaruh sumber dayamanusia dan pengendalian intern terhadap kualitas informasi laporan keuangan dikabupaten muna barat. Sampel pada penelitian ini berjumlah 51 orang pegawai bagiankeuangan keuangan pada setiap OPD pemerintah Kabupaten Muna Barat. Metodepengumpulan data menggunakan kuesioner. Analisis data menggunakan metode analisisdeskriptif dan analisis linear berganda. Hasil penelitian ini menunjukan bahwa: (1)sumber daya manusia berpengaruh positif signifikan terhadap kualitas informasi laporankeuangan di kabupaaten Muna Barat. (2) sistem pengendalian intern berpengaruh positifsignifikan terhadap kualitas informasi laporan keuangan di kabupaaten Muna Barat. (3)sumber daya manusia dan sistem pengendalian intern secara simultan berpengaruhpositif signifikan terhadap kualitas informasi laporan keuangan di kabupaaten MunaBarat.
ANALISIS AKUNTABILITAS DAN TRANSPARANSI PENGELOLAAN DANA DESA TAHUN 2019 (Studi Kasus Pada Desa Landono 2 Kecamatan Landono Kabupaten Konawe Selatan)
Authors: Yusuf Satira , Anto La Ode , Hapsara Made Yoga
Published: February 2022

Penelitian ini bertujuan untuk mengetahui tingkat Akuntabilitas dan TransparansiPengelolaan Dana Desa di Desa Landono 2 Kecamatan Landono Kabupaten KonaweSelatan mulai dari tahap perencanaan, pelaksanaan, penatausahaan, pelaporan danpertanggungjawaban. Teknik analisis data menggunakan teknik analisis deskriptifkualitatif. Metode pengumpulan data dalam penelitian ini yaitu dokumentasi danwawancara. Data yang digunakan adalah data primer yang berisikan wawancara denganpemerintah desa dan masyarakat di Desa Landono 2.Hasil penelitian ini menunjukan bahwa Pengelolaan Dana Desa di Desa Landono 2untuk tingkat akuntabilitas dan transparansi masih belum cukup baik, dimana padapelaksanaan Pengelolaan Dana Desa tidak melibatkan partisipasi masyarakat. PemerintahDesa tidak informatif mengenai hasil pelaksanaan program Dana Desa. Tahap pelaporandan pertanggungjawaban, Pemerintah Desa tidak memberikan informasi mengenaipenggunaan Dana Desa kepada masyarakat. Pemerintah desa masih belum cukup baikdalam mengarsipkan dokumen yang berhubungan dengan Pengelolaan Dana Desa.Pemerintah Desa Landono 2 harus lebih meningkatkan akuntabilitas dan transparansi dalamproses Pengelolaan Dana Desa sehingga pembangunan desa dapat berjalan denganmaksimal.
Allelopathic Potential of Hemp: Implications for Integrated Weed Management
Authors: Shikanai Avery , Gage Karla L.
Published: February 2022

Evolved resistance to herbicides necessitates alternative weed control strategies. Allelopathic crops show promise as an alternative to exogenous herbicides and could be used to reduce establishment, growth, and reproduction of weeds. Individual cannabinoids and terpenes found in hemp (Cannabis sativa L.) show allelopathic potential, but allelopathic effects of plant residue have not been characterized. A laboratory assay found that crude, acetone-soluble hemp extracts diluted to 2.5 mg mL−1 reduced the germination of a bioindicator species. However, tested concentrations below 2.5 mg mL−1 were not more effective than the no-extract control treatment at reducing germination. A greenhouse study found that soil-incorporated hemp residue was not more effective than a maize (Zea mays L.) residue treatment comparison in reducing plant growth. However, a simulated chaff line experiment in the greenhouse showed that the equivalent of 378 g m−2 hemp residue on the soil surface can effectively reduce and delay the germination of waterhemp [Amaranthus tuberculatus (Moq.) Sauer] in comparison to bare-soil, or a maize residue treatment comparison. Together, these results show that incorporated hemp residue will likely not be an effective weed control practice. However, chaff lining hemp residue may be an effective practice for the control of certain weeds and warrants further research in a field setting.
Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents
Authors: Li Fupeng , Liu Fengxiang , Huang Kai , Yang Shengbing
Published: February 2022

With the abuse and misuse of antibiotics, antimicrobial resistance has become a challenging issue in the medical system. Iatrogenic and non-iatrogenic infections caused by multidrug-resistant (MDR) pathogens pose serious threats to global human life and health because the efficacy of traditional antibiotics has been greatly reduced and the resulting socio-economic burden has increased. It is important to find and develop non-antibiotic-dependent antibacterial strategies because the development of new antibiotics can hardly keep pace with the emergence of resistant bacteria. Gallium (III) is a multi-target antibacterial agent that has an excellent antibacterial activity, especially against MDR pathogens; thus, a gallium (III)-based treatment is expected to become a new antibacterial strategy. However, some limitations of gallium ions as antimicrobials still exist, including low bioavailability and explosive release. In recent years, with the development of nanomaterials and clathrates, the progress of manufacturing technology, and the emergence of synergistic antibacterial strategies, the antibacterial activities of gallium have greatly improved, and the scope of application in medical systems has expanded. This review summarizes the advancement of current optimization for these key factors. This review will enrich the knowledge about the efficiency and mechanism of various gallium-based antibacterial agents and provide strategies for the improvement of the antibacterial activity of gallium-based compounds.
Design, Development, and Validation of an Augmented Reality-Enabled Production Strategy Process
Authors: Nassereddine Hala , Veeramani Dharmaraj , Hanna Awad S.
Published: February 2022

The Production Strategy Process (PSP) is an integral part of production planning and control as it defines how production processes are structured and designed and outlines how production will be executed. PSP involves massive information transfer and communication among project participants. While BIM can improve the flow of information, the paradox of designing 3D models in 2D space remains. This paradox indicates that new visualization technologies are needed to leverage the use of information in the PSP. As Industry 4.0, the fourth industrial revolution, continues to evolve, it is imperative that construction firms seek, find, and adopt new technologies. This research employed Augmented Reality (AR) as a new user interface in the PSP. The current state of practice of PSP was investigated and current challenges are identified. The opportunities to integrate AR were defined, and an AR-enabled future state was proposed. Next, an AR-enabled PSP prototype using the Microsoft HoloLens was implemented and validated on a real-world healthcare project. Usability testing was then conducted using a one-on-one protocol to validate the prototype with 20 participants. Surveys were the deployed to qualitatively assess the impact of integrating AR into PSP. The difference between the traditional PSP and the AR-enabled PSP was tested through a series of hypotheses comparing both processes. The results demonstrate that the AR-enabled PSP offers significant benefits over the Traditional PSP: improved collaboration, reduced miscommunication, increased quality and detection of errors, enhanced decision-making, better documentation, better information access, improved information flow, increased input accuracy, and increased integration of safety considerations. Additionally, the technology, software, and hardware were also evaluated, and, on average, the findings demonstrated the potential of AR in production planning.
Multiscale Strain Transfer in Cartilage
Authors: Boos Manuela A. , Lamandé Shireen R. , Stok Kathryn S.
Published: February 2022

The transfer of stress and strain signals between the extracellular matrix (ECM) and cells is crucial for biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation, growth, and homeostasis. In cartilage tissue, the heterogeneity in spatial variation of ECM molecules leads to a depth-dependent non-uniform strain transfer and alters the magnitude of forces sensed by cells in articular and fibrocartilage, influencing chondrocyte metabolism and biochemical response. It is not fully established how these nonuniform forces ultimately influence cartilage health, maintenance, and integrity. To comprehend tissue remodelling in health and disease, it is fundamental to investigate how these forces, the ECM, and cells interrelate. However, not much is known about the relationship between applied mechanical stimulus and resulting spatial variations in magnitude and sense of mechanical stimuli within the chondrocyte’s microenvironment. Investigating multiscale strain transfer and hierarchical structure-function relationships in cartilage is key to unravelling how cells receive signals and how they are transformed into biosynthetic responses. Therefore, this article first reviews different cartilage types and chondrocyte mechanosensing. Following this, multiscale strain transfer through cartilage tissue and the involvement of individual ECM components are discussed. Finally, insights to further understand multiscale strain transfer in cartilage are outlined.
Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes
Authors: Overi Diletta , Carpino Guido , Moretti Marta , Franchitto Antonio , Nevi Lorenzo , Onori Paolo , De Smaele Enrico , Federici Luca , Santorelli Daniele , Maroder Marella , Reid Lola M. , Cardinale Vincenzo , Alvaro Domenico , Gaudio Eugenio
Published: February 2022

Contrasting evidence is present regarding the contribution of stem/progenitor cell populations to pancreatic regeneration in diabetes. Interestingly, a cell compartment with stem/progenitor cell features has been identified in the pancreatic duct glands (PDGs). The aims of the present study were to evaluate pancreatic islet injury and regeneration, and the participation of the PDG compartment in type 2 diabetic mellitus (T2DM) and in an experimental model of diabetes. Human pancreata were obtained from normal (N = 5) or T2DM (N = 10) cadaveric organ donors. Experimental diabetes was generated in mice by intraperitoneal injection of 150 mg/kg of streptozotocin (STZ, N = 10); N = 10 STZ mice also received daily intraperitoneal injections of 100 µg of human recombinant PDX1 peptide (STZ + PDX1). Samples were examined by immunohistochemistry/immunofluorescence or RT-qPCR. Serum glucose and c-peptide levels were measured in mice. Islets in T2DM patients showed β-cell loss, signs of injury and proliferation, and a higher proportion of central islets. PDGs in T2DM patients had a higher percentage of proliferating and insulin+ or glucagon+ cells compared to controls; pancreatic islets could be observed within pancreatic duct walls of T2DM patients. STZ mice were characterized by reduced islet area compared to controls. PDX1 treatment increased islet area and the percentage of central islets compared to untreated STZ mice but did not revert diabetes. In conclusion, T2DM patients show signs of pancreatic islet regeneration and involvement of the PDG niche. PDX1 administration could support increased endocrine pancreatic regeneration in STZ. These findings contribute to defining the role and participation of stem/progenitor cell compartments within the pancreas.
Imaging Arm Regeneration: Label-Free Multiphoton Microscopy to Dissect the Process in Octopus vulgaris
Authors: Imperadore Pamela , Galli Roberta , Winterhalder Martin J. , Zumbusch Andreas , Uckermann Ortrud
Published: February 2022

Cephalopod mollusks are endowed with an impressive range of features that have captured the attention of scientists from different fields, the imaginations of artists, and the interests of the public. The ability to spontaneously regrow lost or damaged structures quickly and functionally is among one of the most notable peculiarities that cephalopods possess. Microscopical imaging techniques represent useful tools for investigating the regenerative processes in several species, from invertebrates to mammals. However, these techniques have had limited use in cephalopods mainly due to the paucity of specific and commercially available markers. In addition, the commonly used immunohistochemical staining methods provide data that are specific to the antigens studied. New microscopical methods were recently applied to vertebrates to investigate regenerative events. Among them, multiphoton microscopy appears promising. For instance, it does not depend on species-related epitopes, taking advantage of the specific characteristics of tissues and allowing for its use in a species-independent way. Here, we illustrate the results obtained by applying this label-free imaging technique to the injured arm of Octopus vulgaris, a complex structure often subject to injury in the wild. This approach allowed for the characterization of the entire tissue arm architecture (muscular layers, nerve component, connective tissues, etc.) and elements usually hardly detectable (such as vessels, hemocytes, and chromatophores). More importantly, it also provided morpho-chemical information which helped decipher the regenerative phases after damage, from healing to complete arm regrowth, thereby appearing promising for regenerative studies in cephalopods and other non-model species.
Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides
Authors: Zhang Ying , Yu Yingying , Gao Jie
Published: February 2022

Nanomedicines provide distinct clinical advantages over traditional monomolecular therapeutic and diagnostic agents. Supramolecular nanomedicines made from in-situ self-assembling peptides have emerged as a promising strategy in designing and fabricating nanomedicines. In-situ self-assambly (SA) allows the combination of nanomedicines approach with prodrug approach, which exhibited both advantages of these strategies while addressed the problems of both and thus receiving more and more research attention. In this review, we summarized recently designed supramolecular nanomedicines of in-situ SA peptides in the manner of applications and design principles, and the interaction between the materials and biological environments was also discussed.
The Interferon Response Dampens the Usutu Virus Infection-Associated Increase in Glycolysis
Authors: Wald Maria Elisabeth , Sieg Michael , Schilling Erik , Binder Marco , Vahlenkamp Thomas Wilhelm , Claus Claudia
Published: February 2022

The mosquito-borne Usutu virus (USUV) is a zoonotic flavivirus and an emerging pathogen. So far therapeutical options or vaccines are not available in human and veterinary medicine. The bioenergetic profile based on extracellular flux analysis revealed an USUV infection-associated significant increase in basal and stressed glycolysis on Vero and with a tendency for basal glycolysis on the avian cell line TME-R derived from Eurasian blackbirds. On both cell lines this was accompanied by a significant drop in the metabolic potential of glycolysis. Moreover, glycolysis contributed to production of virus progeny, as inhibition of glycolysis with 2-deoxy-D-glucose reduced virus yield on Vero by one log10 step. Additionally, the increase in glycolysis observed on Vero cells after USUV infection was lost after the addition of exogenous type I interferon (IFN) β. To further explore the contribution of the IFN response pathway to the impact of USUV on cellular metabolism, USUV infection was characterized on human A549 respiratory cells with a knockout of the type I IFN receptor, either solely or together with the receptor of type III IFN. Notably, only the double knockout of types I and III IFN receptor increased permissiveness to USUV and supported viral replication together with an alteration of the glycolytic activity, namely an increase in basal glycolysis to an extent that a further increase after injection of metabolic stressors during extracellular flux analysis was not noted. This study provides evidence for glycolysis as a possible target for therapeutic intervention of USUV replication. Moreover, presented data highlight type I and type III IFN system as a determinant for human host cell permissiveness and for the infection-associated impact on glycolysis.
Inside-Out: Driving Down Direct Air Capture Costs With High-Efficiency Adsorbents
Authors: Husk Jason C. , Wenz Graham B.
Published: February 2022

As carbon emissions continue to grow, removing carbon dioxide (CO2) from the atmosphere will be necessary to curb the impact of climate change, with the need to remove over a billion tons of CO2 in the next decade. Direct air capture (DAC) is a promising technology for removing atmospheric carbon dioxide, with a handful of systems deployed around the globe. As currently deployed, however, tens of millions of these systems are needed to address current and historic emissions, which means creating an industry the size of the auto industry—along with consuming the associated resources—within the next decade. Improving DAC processes via scale is not enough; focusing on breakthroughs in sorbent performance is needed to reduce the number of systems and sheer volume of resources needed to rapidly bring DAC to the scales required to prevent further climate change. There are roles for government, corporations, and the carbon removal industry to play in enabling infrastructure, increasing demand, and creating clarity to accelerate deployment of DAC and, more broadly, carbon dioxide removal technologies.
Automated Video Monitoring of Unmarked and Marked Honey Bees at the Hive Entrance
Authors: Rodriguez Iván F. , Chan Jeffrey , Alvarez Rios Manuel , Branson Kristin , Agosto-Rivera José L. , Giray Tugrul , Mégret Rémi
Published: February 2022

We present a novel system for the automatic video monitoring of honey bee foraging activity at the hive entrance. This monitoring system is built upon convolutional neural networks that perform multiple animal pose estimation without the need for marking. This precise detection of honey bee body parts is a key element of the system to provide detection of entrance and exit events at the entrance of the hive including accurate pollen detection. A detailed evaluation of the quality of the detection and a study of the effect of the parameters are presented. The complete system also integrates identification of barcode marked bees, which enables the monitoring at both aggregate and individual levels. The results obtained on multiple days of video recordings show the applicability of the approach for large-scale deployment. This is an important step forward for the understanding of complex behaviors exhibited by honey bees and the automatic assessment of colony health.
GSVMA: A Genetic Support Vector Machine ANOVA Method for CAD Diagnosis
Authors: Hassannataj Joloudari Javad , Azizi Faezeh , Nematollahi Mohammad Ali , Alizadehsani Roohallah , Hassannatajjeloudari Edris , Nodehi Issa , Mosavi Amir
Published: February 2022

Background

Coronary artery disease (CAD) is one of the crucial reasons for cardiovascular mortality in middle-aged people worldwide. The most typical tool is angiography for diagnosing CAD. The challenges of CAD diagnosis using angiography are costly and have side effects. One of the alternative solutions is the use of machine learning-based patterns for CAD diagnosis.

Methods

Hence, this paper provides a new hybrid machine learning model called genetic support vector machine and analysis of variance (GSVMA). The analysis of variance (ANOVA) is known as the kernel function for the SVM algorithm. The proposed model is performed based on the Z-Alizadeh Sani dataset so that a genetic optimization algorithm is used to select crucial features. In addition, SVM with ANOVA, linear SVM (LSVM), and library for support vector machine (LIBSVM) with radial basis function (RBF) methods were applied to classify the dataset.

Results

As a result, the GSVMA hybrid method performs better than other methods. This proposed method has the highest accuracy of 89.45% through a 10-fold crossvalidation technique with 31 selected features on the Z-Alizadeh Sani dataset.

Conclusion

We demonstrated that SVM combined with genetic optimization algorithm could be lead to more accuracy. Therefore, our study confirms that the GSVMA method outperforms other methods so that it can facilitate CAD diagnosis.
An Agent-Based Approach to Integrate Human Dynamics Into Disaster Risk Management
Authors: Wu Shengnan , Lei Yu , Yang Saini , Cui Peng , Jin Wen
Published: February 2022

Disaster risk management (DRM) is the application of disaster risk reduction policies and strategies to reduce existing disaster risk and manage residual risk. However, due to dynamic human factors, it is challenging to depict and assess the effectiveness of DRM measures, and their implementation usually lacks a sufficient evidence-based evaluation process. Therefore, this study developed an agent-based model to integrate dynamic human behaviors into the DRM measures and evaluated their effectiveness in casualty reduction. The model was calibrated to simulate the debris flow event at Longchi town, China in 13 August 2010. The early warning system (EWS) and related DRM measures were taken as examples. The effectiveness of different DRM measures was quantitated by comparing the number of potential casualties. The main findings were: 1) EWS was very effective for community-based DRM as it could significantly decrease the average casualties by 30%. 2) Credibility of EWS was critical to its effectiveness. Less credible EWS might reduce its effectiveness by 9%. 3) EWS could be supplemented by other measures to further reduce casualties by 6%. 4) The downside effects of other DRM measures to EWS might exist and reduce its effectiveness by up to 5%. This study put forward an evidence-based approach to help policymakers select more cost-effective DRM measure, especially in the less developed countries where the available resources for DRM are limited.
Systematic Review and Critical Analysis on Dietary Supplements for Male Infertility: From a Blend of Ingredients to a Rationale Strategy
Authors: Garolla Andrea , Petre Gabriel Cosmin , Francini-Pesenti Francesco , De Toni Luca , Vitagliano Amerigo , Di Nisio Andrea , Grande Giuseppe , Foresta Carlo
Published: February 2022

Content

Dietary supplements (DS) for male infertility marketed in Italy were evaluated for composition, concentration of ingredients, and recommended daily dose. A systematic review of literature identified ingredients potentially effective on sperm parameters and their minimal effective daily dose (mED).

Objective

This study was conducted in order to critically evaluate the composition and efficacy of DS marketed in Italy.

Design, Setting, and Participants

This was a systematic review of randomized controlled trials.

Evidence Acquisition

A formula allowed us to classify the expected efficacy of each DS, based on composition. Each DS was scored and included into three classes of expected efficacy: high, low, and none.

Evidence Synthesis

Among 24 supplements, 3 (12.5%) fall in high, 9 (37.5%) in lower, and 12 (50.0%) in no expected efficacy class. DS composition showed 36 substances, 18 with no literature on male fertility and 18 showing positive effect on sperm parameters, thus considered potentially active ingredients (PAI). All DS were mixtures of ingredients, containing from 2 to 17 different substances. Fifteen supplements (65.2%) contained at least 1 ingredient without evidence of efficacy and 21 formulations had PAI dosed below mED. Some PAI were associated to the improvement of specific sperm parameters.

Conclusions

DS were usually blends of many substances that are frequently employed at negligible dose or without any evidence of efficacy on male reproduction. Some ingredients have been demonstrated to be effective on specific sperm parameters by RCTs. We report a list of ingredients with potential efficacy on specific sperm parameters, aimed to allow a tailored use of DS.

Patient Summary

The market of DS for male infertility offers products with potential efficacy in the improvement of sperm parameters but also many with uncertain effects. Based on current scientific literature, our study can help in the choice of DS that are more likely to be effective on specific sperm alterations, so providing the best supplementation for each patient.
Do Relaxin Levels Impact Hip Injury Incidence in Women? A Scoping Review
Authors: Parker Emily A. , Meyer Alex M. , Goetz Jessica E. , Willey Michael C. , Westermann Robert W.
Published: February 2022

Purpose

The aim of this review is to assess the current evidence regarding the impact of relaxin on incidence of soft tissue hip injuries in women.

Methods

A trained research librarian assisted with searches of PubMed, Embase, CINAHL, and SPORTDiscus, with a preset English language filter. The review was completed per the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis methodology. Included studies required assessment of relaxin effects on musculoskeletal health, pelvic girdle stability, or hip joint structures in human subjects. Letters, texts, and opinion papers were excluded.

Results

Our screen yielded 82 studies. Molecularly, relaxin activates matrix metalloproteinases (MMPs) including collagenases MMP-1/-13 and gelatinases MMP-2/-9 to loosen pelvic ligaments for parturition. However, relaxin receptors have also been detected in female periarticular tissues, such as the anterior cruciate ligament, which tears significantly more often during the menstrual cycle peak of relaxin. Recently, high concentrations of relaxin-activated MMP-9 receptors have been found on the acetabular labrum; their expression upregulated by estrogen.

Conclusions

Menstrual cycle peaks of relaxin activate MMPs, which locally degrade collagen and gelatine. Women have relaxin receptors in multiple joints including the hip and knee, and increased relaxin correlates with increased musculoskeletal injuries. Relaxin has paracrine effects in the female pelvis on ligaments adjacent to hip structures, such as acetabular labral cells which express high levels of relaxin-targeted MMPs. Therefore, it is imperative to investigate the effect of relaxin on the hip to determine if increased levels of relaxin are associated with an increased risk of acetabular labral tears.
Valorization of Wet Oily Petrochemical Sludge via Slow Pyrolysis: Thermo-Kinetics Assessment and Artificial Neural Network Modeling
Authors: Naqvi Salman Raza , Ammar Taqvi Syed Ali , Khoja Asif Hussain , Ali Imtiaz , Mehran Muhammad Taqi , Farooq Wasif , Tippayawong Nakorn , Juchelková Dagmar , Atabani A.E.
Published: February 2022

Oily sludge is a hazardous waste stream of oil refineries that requires an effective process and an environment-friendly route to convert and recover valuable products. In this study, the pyrolytic conversion of the wet waste oil sludge was implemented in an autoclave pyrolyzer and a thermogravimetric analyzer (TGA) at 5°C/min, 20°C/min, and 40°C/min, respectively. The kinetic analysis was performed using model-free methods, such as Friedman, Kissenger–Akahira–Sunose (KAS), and Ozawa–Flynn–Wall (OFW) to examine the complex reaction mechanism. The average activation energy of wet waste oil sludge (WWOS) estimated from Friedman, KAS, and OFW methods was 198.68 ± 66.27 kJ/mol, 194.60 ± 56.99 kJ/mol, and 193.28 ± 54.88 kJ/mol, respectively. The activation energy increased with the conversion, indicating that complex multi-step processes are involved in the thermal degradation of WWOS. An artificial neural network (ANN) was employed to predict the conversion during heating at various heating rates. ANN allows complex non-linear relationships between the response variable and its predictors. nH, ΔG, and ΔS were found to be 191.26 ± 2.82 kJ/mol, 240.79 ± 2.82 kJ/mol, and −9.67 J/mol K, respectively. The positive values of ΔH and ΔG and the slightly negative value of ΔS indicate the endothermic nature of the conversion process, which is non-spontaneous without the supply of energy.
Ignition and Combustion Characteristics of N-Butanol and FPBO/N-Butanol Blends With Addition of Ignition Improver
Authors: Wang Yu , Han Jinlin , Maes Noud , Cuijpers Michel , Somers Bart
Published: February 2022

In this study, the ignition and combustion characteristics of fast pyrolysis bio-oil (FPBO) are investigated in a combustion research unit (CRU), which mainly consists of a constant-volume combustion chamber. To fuel the CRU with FPBO, n-butanol and 2-ethylhexyl nitrate (EHN) are used to improve the atomization and ignition properties of the fuel blends, respectively. In the first part of this study, an appropriate proportion of EHN additive into n-butanol is determined based on the balance between the ignition improvement and the amount of EHN addition. Then, the effects of FPBO content (up to 30%) in FPBO/n-butanol blends with the same EHN addition are investigated. The effects of chamber wall temperature on the combustion are also studied. Finally, the different definitions of indicators are determined from the chamber pressure traces to quantitatively depict fuel ignition and combustion characteristics including ignition delay, combustion phasing, end of combustion and burn duration. Experimental results show that a distinct two-stage ignition process can be observed for all cases. For n-butanol with added EHN, the increase of EHN proportion could effectively advance both the low- and high-temperature reaction phases. However, this gain is obviously reduced when the percentage of EHN becomes higher than 8%. For FPBO/n-butanol blends with an addition of EHN, higher FPBO proportions have little effect on the low-temperature reaction phase, while they delay the high-temperature reaction phase. Chamber wall temperature have a significant influence on the ignition and combustion processes of the tested FPBO/n-butanol blends. With these blends, negative temperature coefficient behavior was observed in a chamber wall temperature range of 535–565°C.
Genetic Diversity and Population Structure of Doum Palm (Hyphaene compressa) Using Genotyping by Sequencing
Authors: Omire Agnes , Neondo Johnstone , Budambula Nancy L. M. , Wangai Laura , Ogada Stephen , Mweu Cecilia
Published: February 2022

Doum palm (Hyphaene compressa) is a perennial economic plant primarily growing in Kenya’s Arid and Semi-Arid Lands (ASALs). It is heavily relied upon for food, animal feed, construction materials and medicine, making it an ideal plant for resource sustainability. However, the limited information on its genetic resources has hindered its breeding and conservation studies. This study used the genotyping by sequencing approach to identify Single Nucleotide Polymorphisms. These SNPs were further used to assess the genetic diversity and population structure of 96 H. compressa accessions from Coastal, Northern and Eastern ASAL regions of Kenya using two approaches; reference-based and de novo-based assemblies. STRUCTURE analysis grouped the sampled accessions into two genetic clusters (Cluster 1 and Cluster 2). Cluster 1 included accessions from the Northern region, whereas Cluster 2 included all accessions from Eastern and Coastal regions. Accessions from Kwale (Coastal) had mixed ancestry from both Cluster 1 and Cluster 2. These STRUCTURE findings were further supported by principal components analysis, discriminant analysis of principal components and phylogenetic analysis. Analysis of molecular variance indicated greater genetic variation within populations (92.7%) than among populations (7.3%). An overall FST of 0.074 was observed, signifying moderate genetic differentiation among populations. The results of this study will provide information useful in breeding, marker-assisted selection and conservation management of H. compressa.
Pain and Cellular Migration Induced by Bothrops jararaca Venom in Mice Selected for an Acute Inflammatory Response: Involvement of Mast Cells
Authors: Kondo Fernanda V. , Cabrera Wafa H. K. , Ribeiro Orlando G. , De Franco Marcelo , Jensen José Ricardo , Picolo Gisele , Sant’Anna Morena B. , Spadafora-Ferreira Monica , Borrego Andrea , Ibañez Olga M. , Starobinas Nancy
Published: February 2022

Bothrops jararaca venom (BjV) can induce mast cell degranulation. In order to investigate the role of mast cells and the interference of the host genetic background in the inflammation induced by BjV, we have used mouse strains selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory response (AIR). Mice were pretreated with an inhibitor of mast cell degranulation, cromolyn (CROM), and injected in footpads or intraperitoneally (i.p.) with BjV. Pain was measured with von Frey hairs, cell migration in the peritoneum by flow cytometry, and reactive oxygen species (ROS) production by chemiluminescence assays. The nociceptive response to BjV was higher in AIRmax than AIRmin mice; however, this difference was abolished by pretreatment with CROM. BjV induced peritoneal neutrophil (CD11b+ GR-1+) infiltration and ROS secretion in AIRmax mice only, which were partially inhibited by CROM. Our findings evidence a role for mast cells in pain, neutrophil migration, and ROS production triggered by BjV in AIRmax mice that are more susceptible to the action of BjV.