bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic literature review 2007-2021 Impact of reduced-intensity or nonmyeloablative conditioning regimen in pediatric ALL patients undergoing allogeneic hematopoietic stem cell transplantation
Authors: Garzon Marjorie Triana , Peñaloza Flor Estupiñan , Ramirez Alexandra Porras , Mendoza Alejandro Rico
Published: January 2024

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative
treatment option for patients with acute lymphoblastic leukemia (ALL)
very high-risk in first complete remission and relapsed disease that
achieve remission patients. There is considerable variability in the
regimens preparatory for conditioning patients to be transplanted. In
this systematic review, we identify the impact of reduced-intensity
regimen (RIC) or non-myeloablative (NMAC) on HSCT in pediatric ALL
patients in terms of overall survival (OS) and disease-free survival
(DFS) as reported in the scientific literature. Information was searched
on nine databases, gray literature and bibliography cited in the
selected articles, describing the results of HSCT in ALL in children
between January 01, 2007, and June 30, 2021, with different preparative
regimens. The literature search yielded an overall of 3841 articles; two
articles were duplicates and rejected. This first selection included 363
articles, and 95 were selected for a complete reading. Finally, 16
articles that met the inclusion and exclusion criteria were included,
which analyzed 2136 patients with ALL. RIC, NMAC, or reduced-intensity
myeloablative regimen (RTMAC) was administered to 520 patients,
demonstrating OS and DFS like other cohorts undergoing MAC. This article
concludes the use of RIC, NMAC, or RTMAC is a reasonable option for
those patients with ALL who require a transplant and who suffer from
other comorbidities or have previous transplants, offering survival
rates comparable with myeloablative regimens that, in combination with
new alternatives such as immunotherapy, may become the best alternative.
Breech Specialist Midwives in the OptiBreech Trial feasibility study: an implementation process evaluation
Authors: Dasgupta Tisha , Hunter Sarah , Reid Sharna , Sandall Jane , Shennan Andrew , Davies Siân , Walker Shawn
Published: January 2024

Objective: Refine the programme theory for OptiBreech Care Design:
Concurrent mixed methods implementation process evaluation Setting: 6
NHS hospitals in England participating in the OptiBreech 1 Feasibility
Study Sample: 15 women planning a vaginal breech birth at term and 6
breech lead midwives Methods: Outcomes were recorded on case report
forms and descriptively analysed. Interviews were recorded, transcribed
and analysed using the Theoretical Framework of Acceptability. Iterative
analysis informed subsequent interviews and the on-going process of
implementation across sites. Main Outcome Measures: Acceptability of
service delivery models and their outcomes. Results: Actively recruiting
Trusts implemented services through a dedicated clinic and/or a
proficient intrapartum support service, organised and provided primarily
by a Breech Specialist Midwife. While we identified challenges, this
model has achieved 93% fidelity to the intervention’s goal of ensuring
attendance of OptiBreech-trained professionals at vaginal breech births,
and it is highly acceptable to women. Our initial suggested model of a
multi-disciplinary team composed of 5 obstetricians and 5 midwives does
not appear feasible, due to very low overall current breech experience
levels and the context of current pressures on NHS services.
Conclusions: Appointment of a Breech Specialist Midwife, whose role is
to co-ordinate a dedicated clinic, training and a proficient intrapartum
care team, appears to be highly acceptable to women. This model appears
to be a feasible implementation strategy, in order to test the safety
and effectiveness of OptiBreech Care in a clinical trial, but further
work needs to be done to develop sustainability.
Transvaginal evisceration after vaginal surgery: a case report
Authors: Messaoudi Sohaib , Rezgui Bochra , Maatouk Mohamed , Selmi Marwen , Kbir Ghassen Hamdi
Published: January 2024

We present a case of 72-year-old patient, who underwent a 10 years ago a
total vaginal hysterectomy, was admitted for transvaginal bowel
evisceration. This affection is an exceptional complication of pelvic
surgery. There is no gold standard surgical approach but exploratory
laparotomy is mandatory in case of bowel necrosis.
The basophil activation test has high reproducibility between laboratories and was well integrated in the clinical decision-making process in a specialised centre
Authors: Jaumdally Hannah , Kwok Matthew , Jama Zainab , Hesse-Lamptey Rochelle , McKendry Richard , Galvez Oliver , Daniel Yvonne , Santos Alexandra F.
Published: January 2024

Background: The basophil activation test (BAT) has high
accuracy to diagnose peanut allergy (PA) and can reduce the need for
oral food challenges (OFC); however, so far it has not been incorporated
in clinical practice. Methods: We compared two BAT
methodologies, their performance in two separate laboratories, their
diagnostic utility and impact of BAT in clinical-decision-making in a
specialised centre. Results: 102 children being assessed for PA
were tested on BAT (72 allergic, 30 sensitised tolerant). There was
little internal variation (CV<15%) and a very strong
correlation (Rs>0.95) between BAT performed across
laboratories. The 2 BAT methods were correlated but not interchangeable
and 19% of cases had opposite results. The in-house BAT method (IH-BAT)
was superior, as demonstrated by its better diagnostic performance (area
under the ROC curve 0.929/0.957 versus 0.892/0.895 for CD63/CD203c),
lower number of non-responders (4% versus 14%), lower background
basophil activation (4% versus 9%) and less need for oral food
challenges (29/12 versus 37/20 for OFC/positive OFC). BAT was feasible
and well-accepted by clinicians: no patient with positive BAT was
referred for OFC; only 37% of all tested patients needed an OFC and
14% of these (5% of total) reacted during OFC, which corresponded to
72/89% decrease in OFC/positive OFC, respectively, with the integration
of BAT in the diagnostic work-up for peanut allergy.
Conclusions: The BAT is a robust test that can reliably be
transferred between laboratories; however, different BAT methods are not
interchangeable. BAT was well integrated in the clinical decision-making
process in a specialised centre.
Extraction, Purification and Characterization of Cholesterol Oxidase Enzyme Biosynthesized by Probiotic Lactiplantibacillus plantarum MF1
Authors: farouk Mohamed , mahmoud samar , razik Mohamed Abdel
Published: January 2024

This study aims to purify and characterize the cholesterol oxidase
enzyme extracted from probiotic bacteria isolated from raw cow milk. The
bacterial isolate was identified genotypically by 16S rRNA such as
Lactiplantibacillus plantarum MF1 and then deposited in GenBank
under the accession number MW242720. Cholesterol oxidase from
Lactiplantibacillus plantarum MF1 was purified using acetone and
Sephadex G 100 column chromatography, yielding enzyme recovery and
purification folds of 19.3% and 4.2, respectively. The purity of
purified cholesterol oxidase was confirmed using SDS-PAGE, which
revealed a single protein band at 51 kDa. The optimal conditions for
maximum activity of the purified CHO enzyme produced by
Lactiplantibacillus plantarum MF1 were a 30-minute incubation
period at 30°C, a substrate concentration of 150 μL in the reaction
mixture, and an enzyme concentration of 100 μL in the reaction mixture.
The purified cholesterol oxidase was activated by metal ions (CuSO4),
whereas it was inhibited by CaCl2, MgSO4, ZnSO4, and MnCl2. After four
days of storage at -20 °C, the purified enzyme retained 57% of its
initial enzyme activity. The purified enzyme demonstrated an active
effect on serum human cholesterol samples, resulting in a 29%
reduction.
Association Between Obesity and Surgical Outcomes in patients undergoing minimally invasive Hysterectomy
Authors: Jalloul Randa , Dziadek Olivia , Ward Clara , Bartal Michal
Published: January 2024

Objective: To investigate morbidity associated with minimal invasive
hysterectomy in obese women. Design: This is a retrospective cohort
study using the National Surgical Quality Improvement Project database
from 2014 to 2017. Individuals that underwent a laparoscopic, robotic or
vaginal hysterectomy were included in the study. Our primary outcome was
the composite morbidity (including surgical site infection, sepsis,
pulmonary, thromboembolic, cardiac and renal complications, and death).
Our secondary outcomes included length of hospital stay, readmission,
reoperation, and other surgical complications. A multivariable logistic
regression was performed adjusting for age, race, American society of
anesthesiology classification (ASA), smoking, surgical approach and
operation time. Setting: Hospitals participating in the National
Surgical Quality Improvement Project database. Patients or
Participants:  Patients undergoing minimally invasive hysterectomy for
benign disease. Measurements and Main Results:  39,368 individuals
underwent hysterectomies; 18,767 (47.8%) were obese. Class II obesity
or more was associated with increased risk for the primary outcome
compared to nonobese women. The difference in the primary outcome
primarily was driven by an increased risk of superficial site infection.
Class III obesity was associated with increased risk for length of stay.
There was no difference in the rate of ureteral/bladder/bowel injury,
urinary tract infection, blood transfusion, readmission, surgical site
closure or reoperation between obese and nonobese women. Conclusion: The
rate of surgical morbidity in obese women undergoing minimally invasive
hysterectomy remains higher. It is driven by surgical site infection.
Future interventions such as preoperative optimization as well as
specific wound care interventions in obese patients should be emphasized
Atrial late potentials are associated with atrial fibrillation recurrence after catheter ablation
Authors: Saito Daiki , Fukaya Hidehira , Oikawa Jun , Sato Tetsuro , Matsuura Gen , Arakawa Yuki , Kobayashi Shuhei , Shirakawa Yuki , Ishizue Naruya , Kishihara Jun , Niwano Shinichi , Ako Junya
Published: January 2024

Introduction: Few non-invasive parameters have been identified
for predicting atrial fibrillation (AF) recurrence after catheter
ablation (CA). This study aimed to assess the association between AF
recurrence and atrial late potentials (ALP) measured using P-wave
signal-averaged electrocardiography (P-SAECG). Methods and
results: Consecutive patients with paroxysmal AF who underwent first CA
at our institution between August 2015 and August 2019 were enrolled.
P-SAECG was performed before CA. Two ALP parameters were evaluated: root
mean square voltage during the terminal 20 ms (RMS )
and P-wave duration (PWD). Positive ALP was defined as an RMS
<2.2 µV and/or a PWD >115 ms.
Patients were divided into the Recurrence and Non-recurrence groups
based on AF recurrence at the 1-year follow-up after CA. Of 190 patients
(age: 65±11 years, 37% women) enrolled in this study, 21 (11%) had AF
recurrence. Positive ALP rate was significantly higher in the Recurrence
group than in the Non-Recurrence group (86% vs. 64%, P=0.04)
despite there being no differences in other baseline characteristics
between the two groups. In the multivariate analysis, positive ALP was
an independent predictor of AF recurrence (odds ratio: 3.83, 95%
confidence interval: 1.05–14.1, P=0.04). Conclusion:
Positive ALP on pre-CA P-SAECG was associated with AF recurrence after
CA.
Uterine hemangioma in pregnancy: a case report and systematic review
Authors: Bauters Emma , Aertsen Michael , Froyman Wouter , Merwe Johannes Van der
Published: January 2024

Objectives: This systematic review summarizes all published uterine
hemangioma cases in pregnant women. Search strategy: The databases
PubMed and Scopus were searched systematically. The reference lists of
all retrieved articles were also screened. Selection criteria: The
online tool Rayyan QCRI was used for registration of the selection
process. Articles reporting on cases of uterine hemangioma in pregnancy
were included, non-English articles were excluded. Data collection and
analysis: Data extraction was done by one reviewer and thereafter
verified by the second reviewer. All data were described in a narrative
format. Results: Fifteen case reports were included. In most cases, the
diagnosis was established by antenatal ultrasound and pregnancy course
was uneventful. More than half of the patients developed a postpartum
hemorrhage, necessitating a hysterectomy for bleeding control in four
cases, although the risk for both seemed lower in those patients in whom
the hemangioma was diagnosed before delivery. One case of maternal
mortality and two cases of fetal death were reported. There was one case
of neonatal respiratory morbidity, although the neonatal data were not
routinely reported upon. Conclusion: Current knowledge on uterine
hemangioma in pregnancy is limited, but it seems to hold substantial
risks for both mother and child. We recommend routine screening for this
condition at the standard mid-trimester anomaly scan. Pregnant women
with uterine hemangioma should ideally be cared for in centers of
expertise. An international registry will help to build a better
understanding of this rare pathology. Funding: None.
Integrating multiple stressor research with ecosystem multifunctionality
Authors: Custer Gordon , Dini-Andreote Francisco
Published: January 2024

Environmental and anthropogenic stressors interact to determine the
composition and performance of biological systems. Given the interactive
nature of multiple stressors and the plethora of metrics used for
measuring ecosystem value, we advocate for discussion around efforts
that integrate multiple stressor research with ecosystem
multifunctionality. This new perspective will contribute to a better
understanding of the emergent threats of global change on ecosystem
functioning and provide valuable information concerning conservation
practices and measures.
Species existence and coexistence in response to nutrient enrichment in the Park Grass Experiment
Authors: Yao Qi , Feng Yanhao
Published: January 2024

While three major hypotheses (niche dimension, light asymmetric
competition, soil acidification) are proposed to explain the decline of
plant diversity following nutrient enrichment, our knowledge of
underlying mechanisms remains rather vague. To reveal the cryptic
mechanisms, we analyzed the century-long Park Grass Experiment under
modern coexistence theory by fitting Lotka-Volterra competition models
with time-series data. First, intrinsic population growth rates (r)
decreased, and competitive differences or hierarchies reshuffled,
remarkably with nutrient addition and soil acidification, mostly
favoring grasses over legumes and forbs. Second, intraspecific and
interspecific competition decreased dramatically, but niche differences
increased and decreased respectively, with nutrient addition and soil
neutralization. Lastly, the altered r and competitive differences
effectively explained the diversity loss and recovery via affecting
species existence and coexistence. These findings provide novel
quantitative evidence for the hypotheses and greatly deepen our insights
into fundamental mechanisms driving the response of plant diversity to
nutrient deposition in nature.
Direct canopy uptake of atmospheric reactive N: A significant pathway for airborne nitrogen input to rice paddy ecosystems
Authors: Tian Yuhua , Zhao Xu , Yin Bin , Zeng Ke , Yan Xiaoyuan
Published: January 2024

Increased atmospheric reactive nitrogen (ARN) has significant impacts on
N balance in rice ecosystems. As an important N deposition process,
knowledge on direct canopy uptake of rice is limited. A water-culture
rice-growing system with 15N labeled nutrient solution was developed to
assess canopy uptake of ARN under field conditions. Gross uptake was
assessed using plant N partitioning approach and net gain of ARN through
canopy uptake was estimated based on N balance in the system. We found
gross uptake was 23.1 and 38.2 kg N·ha-1 during
transplantation-elongation and elongation-maturity periods,
respectively. However, 26.9 kg N·ha-1 of labeled fertilizer N was lost
from rice canopy. Therefore, net gain of ARN via canopy exchange was
34.3 kg N·ha-1 over the whole growing season. Our results demonstrate
high amount of direct canopy uptake of ARN input to rice ecosystems—an
important N process that has not been considered in present N budget
establishment.
Utilizing VA-ECMO As A Bridge To Recovery In A Patient With Fulminant Necrotizing Eosinophilic Myocarditis
Authors: Din Mian Tanveer Ud , Shnoda Mina , Kyvernitakis Andreas , Raja Atif Ahmed , Chakravarthy Mithun , Hadi Azam
Published: January 2024

Fulminant necrotizing eosinophilic myocarditis (FNEM) is a rare but
potentially fatal form of myocarditis characterized by new onset heart
failure, often requiring inotropic and mechanical circulatory support
(MCS). If clinical suspicion for the diagnosis is high, early
endomyocardial biopsy (EMB) followed by prompt immunosuppressive therapy
may prevent further decompensation and death.
Vulnerability to riverbank erosion in India and Bangladesh: A review for future research framework
Authors: Sajjad Haroon , Bhuyan Nirsobha , Rahaman Md Hibjur , Ahmed Raihan
Published: January 2024

Riverbank erosion is one of the most perilous calamities which results
in vulnerabilities associated with various dimensions of physical and
human environments. Vulnerabilities to riverbank erosion is reflected in
a multi-faceted form covering ecological, physical, social, economic,
political and physical and psychological health aspects. With regard to
demographic profile, socio-economic conditions and physiographic
setting, India and Bangladesh are severely vulnerable to riverbank
erosion. This paper makes an attempt to analyze the researches on
vulnerability to riverbank erosion in India and Bangladesh. It provides
a summary and analysis of the vulnerabilities to riverbank erosion,
identifies the research gaps and irons out a way forward for future
researches. The possible research gaps are listed after carrying out a
systematic literature review over a period of 34 years from 1988 to
2021. A total of 94 articles were chosen for this study using keyword
search and thorough reading of the abstracts. The deliberation of the
articles was carried out through descriptive and thematic analysis. The
identified research gaps revealed that among various aspects of
vulnerability, political and psychological vulnerabilities to riverbank
erosion are fairly uncharted; ecological vulnerability is also
underrepresented. Studies focused on particular target groups based on
gender, age groups and other socio-cultural parameters are limited and
there is a wide scope of increasing the use of remote sensing, GIS and
hydrodynamic models in assessing vulnerability to bank erosion. Though a
substantial body of work has been produced on riverbank erosion,
vulnerabilities posed by this disaster require to be represented
adequately.
Existence and Uniqueness Results for a Singular Nonlinear Elliptic Equations with Variable Exponents
Authors: Abdelaziz Hellal
Published: January 2024

This paper deals with study of the nonlinear singular elliptic equations
in a bounded domain
$\Omega\subset\mathbb{R}^N$,
$(N\geq2)$ with Lipschitz boundary
$\partial\Omega$, $$
Au=\frac{f}{u^{\gamma(\cdot)}}+\mu,
$$ Where
$A:=-\mathrm{div}\left(\widehat{a}(\cdot,Du)\right)$
is a Leray-Lions type operator which maps continuously
$W^{1,p(\cdot)}_0(\Omega)$ into
its dual
$W^{-1,p’(\cdot)}(\Omega)$, whose
simplest model is the $p(\cdot)$-laplacian type
operator ( i.e.
$\widehat{a}(\cdot,\xi)=|\xi|^{p(\cdot)-2}\xi$
), such taht $f$ is a nonnegative function belonging to the Lebesgue
space with variable exponents
$L^{m(\cdot)}(\Omega)$, with
$m(\cdot)$ being small ( or
$L^{1}(\Omega)$ ) and $\mu$ is a
nonnegative bounded Radon measure, while
$m:\overline{\Omega}\to
(1,+\infty)$,
$\gamma:\overline{\Omega}\to
(0,1)$ are continuous functions satisfying certain conditions depend on
$p(\cdot)$. We prove the existence, uniqueness and
regularity of nonnegative weak solutions or this class of problems with
$p(\cdot)$-growth conditions. More precisely, we will
discuss that the nonlinear singular term has some regularizing effects
on the solutions of our problem which depends on the summability of
$f$, $m(\cdot)$ and the value of
$\gamma(\cdot)$. The functional
framework involves Sobolev spaces with variable exponents as well as
Lebesgue spaces with variable exponents. Our results can be seen as a
generalization of some results given in the constant exponents case.
Physiological and ecological responses of typical mangrove plants to rising sea levels in Hainan, China
Authors: Lv Xiaobo , Li Donghai , Yang Xiaobo , Chen Yiqing , Du Yanjun , Long Wenxing , Zhong Cairong
Published: January 2024

Due to the intensive use of land and global warming, the response of
species within the plant community to environmental changes and the
developmental trend of the community have attracted global attention.
Affected by human disturbance and rising sea levels, mangrove forests
are undergoing a significant reduction in plant density. Due to
unfavorable factors such as increased salinity and prolonged flooding
time accompanying rising sea levels, it is difficult to predict how the
growth and physiological processes of different mangrove individuals
will respond to these factors and what impact these responses will bring
to the development of mangrove plant communities. In this study, we
simulated rising sea levels by controlling light intensity, seawater
salinity, and flooding time, and studied the physiological and
ecological response mechanisms of six representative mangrove species on
Hainan Island, China, to rising sea levels with the goal to predict the
development of mangrove plant communities in this region. The results
showed that tree species distributed at high tidal levels were more
susceptible to rising sea levels than those growing at medium and low
tidal levels. Due to the rise in sea level, increasing flooding time,
and high salinity stress, mangroves would naturally migrate inland.
However, due to human disturbance that resulted in shoreline hardening,
the mangrove retreat space is inadequate as their distribution area
gradually becomes smaller and disappears. If measures are not taken to
restore the natural environment of the offshore coast and allow
mangroves to advance and retreat freely, global warming and rising sea
levels will affect in particular the mangrove species growing at high
tidal levels, such as Excoecaria agallocha, Lumnitzera littorea,
Lumnitzera racemosa, Bruguiera sexangula, and Ceriops tagal.
Relatos del país del Orinoco
Authors: Eslava Mocha Pedro René
Published: January 2024

El país del Orinoco: un territorio tan imaginario como real. Esta región de contrastes y de exóticos paisajes es el escenario donde se recrean historias propias de una tierra enigmática que conserva narraciones y tradiciones arraigadas en la memoria de quienes navegan sus aguas. Relatos del país del Orinoco reúne los recuerdos de un hombre que creció entre la inmensidad de la selva que desborda la rivera del Orinoco; retrata personajes icónicos y experiencias emotivas que marcarán en el imaginario del lector nuevos matices de un “país” desconocido que trasciende fronteras más allá de cualquier mapa.
The influence of radiation on the characteristics of superinsulator films
Authors: Kartalovic Nenad , Stojic Tomislav , Kovacevic Uros
Published: January 2024

The paper considers the effect of radiation exposure on the characteristics
of the superinsulator phase using Monte Carlo simulation of radiation
transport through superinsulator films. The unique physical properties of
the superinsulator state are captured by a 2-D array model of Josephson
junctions to describe the structure of the material. Simulations were
carried out for different film thicknesses, as well as for radiation beams
of different geometries. In the assessment of radiation resistance, the
Monte Carlo method of simulating the passage of radiation through the
material and the deposition of energy gives good results. Using numerical
simulation, along with a precise definition of the problem from the point of
view of the characteristics of the radiation field and the observed material
environment, it is possible to predict the response of thin superinsulator
films to ionizing radiation. Based on the obtained results, suggestions were
given for the possibility of further application of superinsulator materials
in the production of electronic circuits.
Are Private Firms More Aggressive Tax Planners?
Authors: Hoopes Jeffrey L. , Langetieg Patrick T. , Maydew Edward L. , Mullaney Michele S.
Published: January 2024

Drawing on confidential Internal Revenue Service (IRS) data, we examine whether privately held corporations are more aggressive tax planners than their publicly held peers. Contrary to conventional wisdom, we find no consistent evidence that private firms are more aggressive tax planners. We then examine whether private firms’ tax planning differs from that of public firms more generally. We find that private firms engage in more conforming tax planning (planning that also reduces pretax accounting income). However, tests of nonconforming tax planning reveal that private firms generally engage in the same or less planning relative to their public peers. Overall, our findings cast doubt on the belief that private firms are generally more aggressive tax planners than are public firms, but confirm that they engage in more of some forms of general (i.e., conforming) planning.

Data Availability: The IRS provided confidential tax information to Michele S. Mullaney pursuant to an Intragovernmental Personnel Act of 1970 (IPA) agreement through the Statistics of Income (SOI) Joint Statistical Research Program (JSRP).

JEL Classifications: H25; H26; K34; M41.
Empagliflozin Reduces Liver Fat in Individuals With and Without Diabetes
Authors: Abdelgani Siham , Khattab Ahmed , Adams John , Baskoy Gozde , Brown Marissa , Clarke Geoff , Larvenenko Olga , DeFronzo Ralph A. , Abdul-Ghani Muhammad
Published: January 2024

OBJECTIVE

To examine the effect of empagliflozin on liver fat content in individuals with and without type 2 diabetes (T2D) and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin.

RESEARCH DESIGN AND METHODS

Thirty individuals with T2D and 27 without were randomly assigned to receive in double-blind fashion empagliflozin or matching placebo (2:1 ratio) for 12 weeks. Participants underwent 75-g oral glucose tolerance testing and measurement of liver fat content with MRS before therapy and at study end. Hepatic glucose production before the start of therapy was measured with 3-3H-glucose.

RESULTS

Empagliflozin caused an absolute reduction of 2.39% ± 0.79% in liver fat content compared with an increase of 0.91% ± 0.64% in participants receiving placebo (P < 0.007 with ANOVA). The decrease in liver fat was comparable in both individuals with diabetes and those without (2.75% ± 0.81% and 1.93% ± 0.78%, respectively; P = NS). The decrease in hepatic fat content caused by empagliflozin was strongly correlated with baseline liver fat content (r = −0.62; P < 0.001), decrease in body weight (r = 0.53; P < 0.001), and improvement in insulin sensitivity (r = −0.51; P < 0.001) but was not related to the decrease in fasting plasma glucose or HbA1c or the increase in hepatic glucose production.

CONCLUSIONS

Empagliflozin is effective in reducing liver fat content in individuals with and without T2D. The decrease in liver fat content is independent of the decrease in plasma glucose concentration and is strongly related to the decrease in body weight and improvement in insulin sensitivity.
FACTORES DETERMINANTES DE LA CALIDAD DEL EMPLEO EN BOLIVIA
Authors: Salazar Aramayo Julio Álvaro , Pereira Delgadillo Marcos Alfredo Alfonso , Iraizos Quintanilla Dillis
Published: January 2024

El presente trabajo de investigación plantea un modelo logit de regresión con objeto de establecer los factores o variables independientes que se asocian con el comportamiento del Índice Multidimensional de Calidad del Empleo en Bolivia. Como base de datos se emplean las Encuestas de Hogares de las gestiones 2011 a 2021, realizadas por el Instituto Nacional de Estadística (INE). Se establece en promedio, que si el individuo tiene un contrato de trabajo como personal de planta disminuye en 40.94 % la probabilidad de contar con un empleo de mala calidad para el periodo pre pandemia (2011-2019), mientras que para el periodo de pandemia (2020-2021) no se cuenta en las encuestas de Hogares de estos años con una variable que se asocie a los contratos de trabajo; por otro lado no aportar a las AFPs aumenta en 20.93 % la probabilidad de tener un empleo de mala calidad para el periodo 2011-2019, y en 22.11% para el periodo 2020-2021 , la condición de ser mujer aumenta en 4.71% la probabilidad de contar con un empleo de mala calidad para el periodo 2011-2019, y, disminuye en 3.50 % la probabilidad de contar con un empleo de mala calidad para el periodo 2020-2021; además, cada año adicional de estudio disminuye la probabilidad de tener un empleo de mala calidad en 1.27% para el periodo 2011-2019 y en 0.21% para el periodo 2020-2021. Finalmente, otras variables de influencia son la edad, las horas de trabajo semanales y el tamaño de la empresa en la que trabaja.
El taller filosófico de Martin Heidegger. Contexto y realización de los “ejercicios de lectura” en la época de la prohibición docente
Authors: Xolocotzi Yáñez Angel
Published: January 2024

La prohibición docente a la que fue acreedor Martin Heidegger entre 1946 y 1951 fue uno de los resultados de su compromiso con el nacionalsocialismo, principalmente al asumir la rectoría de la Universidad de Friburgo de 1933 a 1934. La situación con la propia universidad y su experiencia docente de más de 30 años lo lleva a sugerir modos alternos en la docencia que concluyen en “ejercicios de lectura” realizados en el domicilio del filósofo entre 1950 y 1951. Esta experiencia docente es motivo de múltiples reflexiones heideggerianas sobre una idea de enseñanza que correspondiera a su pensar y a lo cual se alude como “taller” (Werkstatt) en tanto oficio artesanal (Handwerk). El presente artículo destaca la relevancia de esta propuesta a partir de su implementación en 1950 con los ejercicios sobre el problema de la causalidad.
Narrativa (auto)biográfica
Authors: Vorpagel Fernanda Seidel , Cousin Cláudia da Silva
Published: January 2024

Apresenta-se uma escrita reflexiva (auto)biográfica acerca de experiências formativas da professora pesquisadora e educadora ambiental, como estratégia para a interpretação e emergência de sentidos pedagógicos do ser professor(a). Como a escrita (auto)biográfica contribui para a compreensão das experiências fundantes no processo formativo da professora-educadora ambiental? A narrativa está centrada num cenário de Pesquisa-Formação e fundamentada no método fenomenológico-hermenêutico, em atenção às quatro categorias estruturantes para a reflexão do processo de investigação: espacialidade; corporeidade; temporalidade e relacionalidade (Van Manen, 2003). Compreende-se que a experiência pode vir a constituir diferentes signos e significados, atribuídos pela subjetividade do sujeito, de acordo com a circunstancialidade socioambiental do momento vivido.
Onde está o sujeito?
Authors: Teixeira Daniel Alves
Published: January 2024

Buscamos uma análise acerca dos desdobramentos da questão do sujeito à luz das diversas críticas que a ela se levantaram nos anos pós-estruturalistas e diante da ascensão do neoliberalismo como ideologia dominante em todo o mundo. Relegada como questão metafísica da modernidade, ou como resíduo do cientificismo positivista, a categoria de sujeito tem sido notadamente objeto de desconstrução, ou, quando não, de simples rejeição. Se apoiando sobre um duplo questionamento, de sua possível pertinência para o pensamento psicológico e filosófico atual, como dos possíveis atores da transformação social diante das transformações sofridas que o capitalismo tardio impõe à categoria de proletariado, através do pensamento de Alain Badiou e Slavoj Žižek, tentamos afastar a tendência linguística que hoje pauta grande parte das análises sobre o sujeito e os processos subjetivos para tentar apontar a importância de uma teoria das verdades que renove as bases ontológicas do pensamento e a visão sobre a dialética materialista. Uma teoria do sujeito assentada sobre um conceito de verdade se mostra assim um potencial para repensar o homem enquanto criador.
PENYULUHAN ARSIP DINAMIS DAN UNDANG-UNDANG TENTANG KEARSIPAN
Authors: Wahyudi Heru , Nairobi Nairobi , Ambya Ambya , Usman Moneyzar , Suparta I Wayan
Published: January 2024

Arsip sebagai rekaman kegiatan dan berbagai bentuk tentu memiliki peran penting dalam setiap organisasi. Dunia pendidikan tentu tidak terlepas dari kearsipan, dikarenakan arsip yang terkelola dengan baik akan bermanfaat sebagai sumber ilmu pengetahuan untuk dipelajari oleh seluruh pihak yang membutuhkan dimasa yang akan datang. Pengelolaan arsip perlu menjadi perhatian berbagai pihak terutama civitas akademika, karena arsip dapat sebagai salah satu metode penentuan keputusan. Namun, tentu dalam pengelolaannya menghadapi kendala, seperti kurangnya sadar arsip. Dengan demikian, tim pengabdian Universitas Lampung mengadakan kegiatan sosialisasi untuk meningkatan sadar arsip di Lingkup Fakultas Teknik Universitas Lampung. Kegiatan ini dikuti oleh 30 peserta. Hasilnya kegiatan ini direspon baik oleh peserta. Kedepannya diharapkan dapat dilaksanakan kegiatan sosialisasi di masing-masing fakultas yang ada di Universitas Lampung agar meningkatkan kualitas kearsipan. Selain itu, dari sisi sarana prasarana yang mendung arsip dapat ditingkatkan, termasuk pada penganggaran yang dialokasikan untuk keberlanjutan arsip lebih direncanakan secara strategis. Adanya fasilitasi sarana prasana arsip diharapkan dapat membantu user dalam pemanfaatan arsip dalam berbagai keperluan.
Equity, Diversity, and Inclusion in Institutional Research Data Management Strategies
Authors: Wong Sabrina
Published: January 2024

Research data management (RDM) is a field of emerging concern for academic librarians. As funder agencies increasingly mandate institutions and researchers to ethically and responsibly manage their research data, academic librarians are frequently tasked with creating institutional strategies and services to support researchers. This article explores how a racialized librarian at a medium-sized, teaching-focused Canadian university created an institutional research data management strategy through a process informed by critical librarianship research and contributive justice (Gomberg, 2016; Honma & Chu, 2018). It examines the lack of equity, diversity, and inclusion (EDI) principles in both funder directives and RDM research literature and proposes an approach to do institutional RDM work in an EDI-centered way.
Risiko Penurunan Kondisi Kesehatan Mental pada Remaja Pengguna Media Sosial yang Melakukan Self-diagnose
Authors: Affandi Amanda Audrey
Published: January 2024

The existence of information technology, especially internet bring increase awareness about mental health. On the other hand, the abundance of this information on internet and lack of understanding from adolescence about dynamics of mental health disorders bring negative impact of self diagnose. This research purposes to reveal the picture of self diagnose with adolescence mental health which social media user, the psychological impact, also what role social media do for the phenomenon. Methods of this research are qualitative methods with phenomenology design. Data collected with semi- structured interview with 4 participants (16-17 years old, 50% women) that already did a self diagnose and active on social media. Analysis technique use in this research is thematic research. The results are that all participants are curious about their mental health condition and sense of their mental illness symptoms, so that they search for information about their mental health from social media on the internet. This self-diagnosed behavior appears when they believe what happened to themselves are the same with mental health disorders. This what bring impact on their psychological such as worried, fear, even wakeful. Self diagnose without validation from professional mental health worker could trigger cognitive process to misunderstanding and false belief about the condition of their mental health and bring up a negative psychological impact.
ANALISIS PENGELOLAAN DAN AKUNTABILITAS LAPORAN KEUANGAN BADAN USAHA MILIK DESA (BUMDES) DI DESA PASIRIPIS
Authors: Marlinda Marlinda , Sudarma Ade
Published: January 2024

Tujuan penelitian ini untuk mengetahui bagimana pengelolaan dan akuntabilitas laporan keuangan dari Badan Usaha Milik Desa (BUMDes) di Desa Pasiripis. Metode yang digunakan merupakan deskriptif pendekatan kualitatif, teknik pengumpulan data yaitu dengan cara observasi, wawancara dan dokumentasi, teknik analisis data yaitu dengan cara pengumpulan data, reduksi data, penyajian data dan pengambilan kesimpulan verifikasi.

Hasil penelitian ini adalah menganalisis penyajian laporan yang masih menggunakan laporan buku kas biasa pada umumnya dan pengelelolaan yaitu perencanaan (planning), pengorganisasian (organizing), pelaksanaan (actuacting), pengawasan (controlling). Untuk akuntabilitas yaitu akuntabilitas vertikal (internal) dan akuntabilitas horizontal (eksternal).
Developing a national surveillance system for stroke and acute myocardial infarction using claims data in the Republic of Korea: a retrospective study
Authors: Kim Tae Jung , Lee Hak Seung , Kim Seong-Eun , Park Jinju , Kim Jun Yup , Lee Jiyoon , Song Ji Eun , Hong Jin-Hyuk , Lee Joongyub , Chung Joong-Hwa , Kim Hyeon Chang , Shin Dong-Ho , Lee Hae-Young , Kim Bum Joon , Seo Woo-Keun , Park Jong-Moo , Lee Soo Joo , Jung Keun-Hwa , Kwon Sun U. , Hong Yun-Chul , Kim Hyo-Soo , Kang Hyun-Jae , Lee Juneyoung , Bae Hee-Joon
Published: January 2024

Objectives: Limited information is available concerning the epidemiology of stroke and acute myocardial infarction (AMI) in the Republic of Korea. This study aimed to develop a national surveillance system to monitor the incidence of stroke and AMI using national claims data.Methods: We developed and validated identification algorithms for stroke and AMI using claims data. This validation involved a 2-stage stratified sampling method with a review of medical records for sampled cases. The weighted positive predictive value (PPV) and negative predictive value (NPV) were calculated based on the sampling structure and the corresponding sampling rates. Incident cases and the incidence rates of stroke and AMI in the Republic of Korea were estimated by applying the algorithms and weighted PPV and NPV to the 2018 National Health Insurance Service claims data.Results: In total, 2,200 cases (1,086 stroke cases and 1,114 AMI cases) were sampled from the 2018 claims database. The sensitivity and specificity of the algorithms were 94.3% and 88.6% for stroke and 97.9% and 90.1% for AMI, respectively. The estimated number of cases, including recurrent events, was 150,837 for stroke and 40,529 for AMI in 2018. The age- and sex-standardized incidence rate for stroke and AMI was 180.2 and 46.1 cases per 100,000 person-years, respectively, in 2018.Conclusion: This study demonstrates the feasibility of developing a national surveillance system based on claims data and identification algorithms for stroke and AMI to monitor their incidence rates.
ON THE METHOD FOR ASSESSING THE QUALITY OF E-LEARNING RESOURCES
Authors: Grigoryan Nana , Harutyunyan Yeranuhi , Grigoryan Zara
Published: January 2024

ABSTRACT

Without the introduction of modern e-learning resources, it is hard to imagine a quality, understandable education that meets modern trends and standards. Under the current circumstances, one of the most important issues facing the world educational community is the problem of searching e-learning resources for quality assessment methods. Assessment is a multi-criteria issue that is very relevant in the current trends of ICT-oriented education and requires the use of multi-criteria decision-making methods.

The purpose of this article is to introduce an interesting approach for evaluating the quality of e-learning resources, based on the method of analysis of hierarchy.

The presented method is not hard to apply; it is oriented for pedagogical purposes and can also be used in the decision-making process for any multi-criteria problem within the field of education.
THE ISSUE OF INTEGRATED VISUAL ARTS EDUCATION AT SCHOOL
Authors: Ghalayants Marina
Published: January 2024

This article presents the issues related to the reforms of public education, strengthening of interdisciplinary links of teaching, applied techniques and problems. It concerns the issue of integrated visual Art within the school education system and emphasizes its importance for development of new coming generation within the digital reality of today’s life.

The implementation of changes in regular or professional schools first of all means improving the quality of education, developing new levels of knowledge and worldview of students. And in order for students to understand the basics of natural and social sciences, the laws concerning the development of society, first of all it is extremally necessary to change the nature of education, which should not be reproductive, but developing or teaching. With this pedagogical approach, students will be able to solve cognitive problems, make analysis, generalizations, comparisons, reflections, explain a given phenomenon or reality using the knowledge obtained from different subjects.

Desk review is used as a research method to select the articles and publications reflecting visual art in education and its integration in school life. Detailed analyses of existing literature prove that integrated visual art in public school enables students’ high-level thinking and productive participation in lessons.
ANALISIS STRATEGI KOMUNIKASI KORPORAT TERHADAP KEBERHASILAN ORGANISASI DALAM MANAJEMEN BISNIS
Authors: Mahrani Desi Khairunnisa , Puryanti Dewi
Published: January 2024

Strategi komunikasi korporat yang efektif mencakup berbagai elemen seperti pengelolahan pesan, pemilihan saluran komunikasi yang tepat, pemahaman kelompok sasaran dan adaptasi terhadap dinamika pasar. Melalui analisis strategi komunikasi yang cermat, organisasi dapat lebih memahami bagaimana menyusun dan menyampaikan pesan mereka sehingga dapat diterima dengan baik oleh pemangku kepentingan. Metode penelitian kualitatif dengan pendekatan deskriptif, yang mengunakan metode pengumpulan data berupa wawancara serta observasi atau berfokus pada pengamatan yang mendalam mengenai “analisis strategi komunikasi terhadap keberhasilan organisasi.  Strategi komunikasi korporat adalah sebuah rencana terpadu yang dirancang dengan mengelola dan menyampaikan pesan secara efektif kepada berbagai pemangku kepentingan (stakeholders) dalam konteks perusahaan atau organisasi. Tujuan utamanya adalah menciptakan pemahaman, dukungan, dan citra positif terhadap perusahaan, dimana Strategi komunikasi korporat melibatkan komunikasi internal dan eksternal perusahaan hal ini dilakukan agar dapat mengimplementasikan seluruh rencana sesuai dengan tujuan yang telah diidentifikasi. Sehingga hal ini sesuai dengan peran manajemen dalam keberhasilan organisasi melalui strategi komunikasi korporat berupa pengelolaan sumber daya, pengukuran kinerja serta adaptasi dalam perubahan yang terjadi serta perhatian melalui etika dan tanggung jawab sosial yang merupakan elemen- elemen manajemen yang dapat mempengaruhi keberhasilan dalam strategi komunikasi korporat dan kinerja terhadap organisasi secara keseluruhan  sehingga dapat dengan mudah  untuk mencapai tujuan organisasi dan memperkuat citra perusahaan.
Targeted transcriptomic analysis of synovial tissues from horses with septic arthritis treated with immune-activated mesenchymal stromal cells reveals induction of T-cell response pathways
Authors: Pezzanite Lynn M. , Chow Lyndah , Engiles Julie B. , Kurihara Jade , Plaisance Cody , Goodrich Laurie R. , Dow Steven
Published: January 2024

OBJECTIVE

To investigate mechanistically the reported beneficial effects of immune-activated mesenchymal stromal cell (MSC) therapy to treat equine septic arthritis, leveraging Nanostring technology.

ANIMALS

8 Quarter Horses with induced tibiotarsal Staphylococcus aureus septic arthritis treated IA with either Toll-like receptor-3 agonist polyinosinic:polycytidylic acid–activated MSCs + vancomycin antimicrobials (TLR-MSC-VAN; n = 4) or antimicrobials (VAN; 4).

METHODS

Synovial tissues were collected and fixed in neutral-buffered 10% formalin, and formalin-fixed paraffin-embedded synovial and osteochondral tissues were sequenced using a custom-designed 200-gene equine Nanostring nCounter immune panel to directly quantify expression of key immune and cartilage-related genes. Immunohistochemistry to detect CD3+ T cells was performed on synovial tissues to further quantify T-cell infiltration in TLR-MSC-VAN– versus VAN-treated joints.

RESULTS

Comparison of synovial transcriptomes between groups revealed moderate changes in differential gene expression, with upregulated expression of 9 genes and downregulated expression of 17 genes with fold change ≥ 2 or ≤ −2 and a significant false discovery rate–adjusted P value of ≤ .05. The most upregulated genes in TLR-MSC-VAN–treated horses included those related to T-lymphocyte recruitment and function, while pathways related to innate immune activation and inflammation were significantly downregulated. Immunohistochemistry and quantitation of CD3+ T-cell infiltrates revealed a numerically greater infiltrate in synovial tissues of TLR-MSC-VAN–treated horses, which did not reach statistical significance in this small sample set (P = .20).

CLINICAL RELEVANCE

Targeted transcriptomic analyses using an equine Nanostring immune and cartilage health panel provided new mechanistic insights into how innate and adaptive immune cells within synovial tissues respond to TLR-activated MSC treatment when used to treat septic arthritis.