bluuebunny/crossref_metadata_2025 huggingface dataset:
Preventing And Combating Domestic Violence: Some Aspects
Authors: Petechel O.Yu.
Published: December 2024

The article is devoted to the study of the current and perhaps the most latent social phenomenon - domestic violence. The author discusses the main provisions of the Istanbul Convention on the Prevention and Combating of Violence against Women and Domestic Violence. In addition, the concepts, features, types of domestic violence are analyzed. The article characterizes the methods of domestic violence in terms of its types: physical, mental, sexual and economic. In addition, special attention is paid to measures to prevent this negative phenomenon. In the research, the author analyzes the main areas of prevention and counteraction to domestic violence. In particular, it is proposed to raise public awareness about the types and forms of domestic violence, the formation of public opinion leaders (in politics, community service, culture, journalism, show business, bloggers, etc.) a clear civic position on intolerance to domestic violence, condemnation, involvement of NGOs and charitable foundations for the process of preventing domestic violence and providing them with opportunities to receive financial support from state or local budgets, and others.
Fictitious Divorce: Theory And Practice
Authors: Skhab-Buchynska T.Ya.
Published: December 2024

The article examines the issue of the possibility of recognizing the divorce as fictitious. The author analyses theoretical provisions and judicial practice on the problems and prospects of recognizing divorce as fictitious. It is proposed to allow recognizing the divorce as fictitious, regardless of the order in which the marriage was dissolved: administratively - by bodies of state registration of acts of civil status, or by a court. The article clarifies the circumstances that are taken into account by the court in the process of considering cases related to fictitious divorce.
Ukraine as a member of the Commonwealth of Independent States and the process of leaving the organization
Authors: Adamovych S.V.
Published: December 2024

In this article the author conducts a research on the role of the Ukrainian state in the process of creating the Commonwealth of Independent States in 1991, intergovernmental cooperation of Ukraine as a part of the Commonwealth and law aspects of Ukraine leaving the intergovernmental organization. In the author’s opinion a clear international-law position of Ukraine towards preservation of its own sovereignty and independence did not allow Russian Federation to transform CIS in an updated Soviet Union with the dominance of russian state factors. In the process of cooperation in the CIS format Ukraine limited itself to the status of a member of organization and rejected its formal membership. Ukraine did not sign CIS Charter, stood up against formation of executive structures of CIS and did not become a part of the military aspect of CIS - Collective Security Treaty Organization, agreed to economic cooperation with reservations. It allowed Ukraine to concentrate more on bilateral economic relations with post-soviet countries and to follow the pace of European law and economic integration with the European Union. Instead, Ukrainian state focused its activity in the CIS format only on economic cooperation with post-soviet republics and on the preservation of the exsisting since the period of Soviet Union and necessary for Ukraine intergovernmental cooperation. After russian military invasion of Ukraine and violation by Russian Federation of territorial integrity of the country in 2014 CIS did not condemn Russia’s aggresion and the procedure of Ukraine leaving CIS started. This process is accompanied by long-term legal procedures for denunciation of agreements signed by Ukraine in the CIS format.
The concept of the state constitution in political and legal views of Petro Poltava
Authors: Svorak S.D. , Slubskyi O.R.
Published: December 2024

The Article analyses and studies the problems of state constitution in Ukraine both in historical retrospect and during the national liberation war in the 40-50s of the XX century through the prism of political and legal views of the active participant in this war, patriot, soldier, member of underground movement and theorist of Ukrainian constitution Petro Poltava. Emphasis is placed on the main concept of the formation of the national state in Ukraine, which is the Ukrainian Independent United State in the Ukrainian ethnographic territories. The publication clearly and unequivocally affirms the opinion of Petro Poltava that an independent national state is the only form of political organisation of the people of Ukraine that provides for the best conditions for comprehensive development.The view of Petro Poltava, who is the practitioner-founder of the Ukrainian Supreme Liberation Council, on the main aspects of the formation and activity of the Ukrainian Parliament in the period 40-50s of the 20th century is summarised. The author of theoretical and legal works Petro Poltava categorically considered the need to destroy the territorial integrity of the USSR and rebuild the USSR in territorial and political terms on the principle of independent national states of all former Soviet peoples while respecting their rights to national self-government.Therefore, P. Poltava’s views on state constitution in Ukraine remain extremely relevant nowadays.The logical conclusion of the publication is the opinion of Petro Poltava that the fate of Ukraine will be decided not in the parliament of the invader and not in the offices of diplomats, but on the battlefield in Ukrainian villages and cities, in Ukrainian forests and steppes. The popular Ukrainian masses and indeed an independent state, the Ukrainian people will be able to build only on their own, because with the help of neighboring states, according to Peter Poltava we must pay dearly with territory or independence
Optimization of Enterprise Costs Through Outsourcing in Accounting and Taxation in the Context of Anti-Crisis Management
Authors: Kuzmin Tetiana , Leshchuk Halyna , Savkiv Uliana , Sas Liudmyla
Published: December 2024

The article examines the role of outsourcing in accounting and taxation as an effective tool for optimizing the costs of enterprises in the context of anti-crisis management. An assessment of the state of outsourcing companies in the field of accounting, auditing, and tax consulting over the past ten years has established an upward trend of increasing demand for these services. The main motives for the use of accounting and taxation outsourcing services by enterprises were determined, and they include increasing the business profitability; growth in the level of anti-crisis management; optimization of activity costs; application of modern IT technologies; increasing concentration on conducting business activities; timely response to changes in the external environment. The external factors influencing the change in the volume of outsourcing services provided in the field of accounting, auditing, and tax consulting over the last ten years have been studied, among them: the economic consequences of the COVID-19 pandemic; political and military instability; changes in legislation; decrease in investment. The main advantages of outsourcing services are analyzed, which allow for the reduction of costs, the increase in the efficiency of operations, and the adaptation to changes in the economic environment. The main trends in the development of outsourcing in accounting and taxation in the context of crisis management have been analyzed, namely: the growth in demand for specialized services, the development of new technologies, increased focus on analytics and forecasting, the shift to cloud technologies, effective risk management, and the expansion of the range of services. It has been substantiated that the further development of the outsourcing market in accounting and taxation in Ukraine will be closely linked to the advancement of electronic document management, the creation of legislative acts regulating outsourcing relations, the automation of accounting processes, as well as the implementation of “Internet accounting” with remote access through web interfaces and the use of cloud technologies.
The Impact of Logistics and Key Macroeconomic Indicators on the Development of the Startup Ecosystem in Europe
Authors: Yakubiv Valentyna , Tomashevska Antonina , Piatnychuk Iryna , Turovska Liliia , Carter Finbarr
Published: December 2024

The article highlights that the synergetic relationship between macroeconomic indicators and logistics efficiency shapes the trajectory of startup ecosystems and global economies. By leveraging tools such as the Logistics Performance Index (LPI) and the Global Startup Ecosystem Index (GIS), policymakers and business leaders gain insights into the interconnectedness of infrastructure, economic output, and innovation. The Global Knowledge Index (GKI) and Global Innovation Index (GII) further reveal the intellectual and creative capacities of nations, while GDP per capita and the Capital Investment Index (CII) underline the financial underpinnings of economic competitiveness. Much of the analysis delves into the transformative impact of modern logistics solutions. Innovative technologies like the Internet of Things (IoT) enhance supply chain visibility and efficiency, while warehouse automation and big data analytics streamline operations. Blockchain technology, with its transparency and security, fosters trust and efficiency in supply chains, a critical factor for startups seeking cost-effective and reliable logistics frameworks. Through correlation analysis, the article underscores the measurable impact of these macroeconomic and logistical elements on the growth of startup ecosystems. Countries that effectively integrate these indicators are better positioned to attract investments, nurture entrepreneurial activity, and achieve sustainable economic growth. The findings suggest that fostering a dynamic startup ecosystem requires an integrated approach, combining robust macroeconomic policies with cutting-edge logistical innovations. This strategy not only propels startups into the competitive global market but also strengthens the economic fabric and welfare of the population.
Social Entrepreneurship in Providing Employment: the Experience of Poland and Ukraine
Authors: Shpykuliak Oleksandr , Shelenko Diana , Balaniuk Ivan , Diuk Аnna , Mazur Hennadii , Balaniuk Sergiy , Boichuk Andrii
Published: December 2024

Social enterprises play a key role in addressing social, environmental, and educational challenges by leveraging social capital to create high-impact solutions. Examples of social enterprises in Ukraine and Poland demonstrate how innovative approaches combined with social initiatives contribute to solving pressing issues and fostering sustainable development in local communities. The study examines the dynamics of social entrepreneurship development in Ukraine within the context of institutionalizing this form of economic activity to increase employment. It has been established that the development of social entrepreneurship in Ukraine remains insufficient and requires both government support and public recognition. The conceptual foundation of social entrepreneurship is based on understanding the social responsibility of businesses to society. This activity combines entrepreneurial spirit with a non-profit character, directing all income toward reinvestment. The research identifies development pathways for social entrepreneurship in Ukraine and Poland, outlining prospects for its institutional establishment. Analysis reveals that the diversity of statuses, forms, and sectoral specifics of social enterprises in Ukraine is shaped by the quality of social capital. The institutional structure and organizational-economic functionality of social enterprises in Poland were analyzed. It was emphasized that classic social enterprises are virtually absent in Ukraine due to a lack of specific institutional and legal regulations. Instead, hybrid structures such as social cooperatives or farming enterprises for veterans operate in line with certain social entrepreneurship criteria. The study highlights the importance of comprehensive institutional support for social entrepreneurship in both countries, contributing to its effective development and increasing social and economic benefits.
A Review on the Nature Economics
Authors: Hudson Charles Ray , Loo Dennis
Published: December 2024

Understanding that environmental resources are crucial to economic prosperity, nature economics studies the complex interrelationships between the natural world and economic systems. Nature economics aims to promote a peaceful coexistence between human activity and the environment by incorporating sustainability, resource management, and ecosystem valuation ideas into conventional economic models. Examining the function of natural resources in economic systems, the effects of environmental externalities, and the necessity of sustainable development, and we will explore the core ideas of nature economics.
"Creemos sólo en lo que está bien contado". Negociaciones narrativas del discurso posfactual en "Blanco nocturno" de Ricardo Piglia
Authors: Wilhelms Lina
Published: December 2024

El artículo analiza la novela policial Blanco nocturno (2010) de Ricardo Piglia en el contexto de la era de la posverdad, argumentando que la obra de Piglia explora el trasfondo económico y político de una creciente cultura de desconfianza hacia las verdades oficiales. Se destaca el papel del neoliberalismo en el surgimiento de esta cultura de la posverdad y cómo los procesos económicos, como la financialización y la globalización, pueden conducir a una crisis epistemológica. La novela Blanco nocturno es un excelente ejemplo de cómo los individuos que se aferran a las promesas modernas pueden adoptar una actitud paranoica en la tensión entre la supuesta libertad y la real experiencia de una pérdida de control.
¿Qué hacer si la disrupción se volvió de extrema derecha?: un análisis cultural de las voces discordantes de Camila Sosa Villada y César González
Authors: Relva Lisandro , Gasel Alejandro Fabián
Published: December 2024

Este artículo realiza un análisis desde la crítica cultural de la producción de Camila Sosa Villada y César González, dos voces que consideramos discordantes en una escena contemporánea signada por la emergencia y el relativo dominio institucionalizado de la extrema derecha en Argentina. A partir de una relectura tanto de textos como de intervenciones públicas de lxs autorxs, plantearemos su condición de agentes culturales que logran lidiar efectivamente con las narrativas disruptivas promovidas por la ultraderecha mediante una estética de la discordancia: en su posición enunciativa es posible leer un gesto de resistencia a ser interpretado por otros (en un amplio espectro ideológico que involucra también al progresismo) que les permite hacer oír la complejidad y las contradicciones que articulan la propia voz. El origen villero, en González, y la marca travesti, en Sosa Villada, son esgrimidos no como esencia identitaria sino como potencia artístico-política.
Consideraciones familiares y de Estado en el proyecto de «embajada» de Constanza de Acuña en París (1618)
Authors: Herrero García Diego
Published: December 2024

El proyecto de «embajada» en solitario de Constanza de Acuña, primera condesa de Gondomar, en Francia en 1618 constituye un episodio poco conocido mas de suma relevancia dentro de los viejos/nuevos debates en torno al carácter formal o informal de la intervención femenina en la diplomacia de la Edad Moderna, en tanto prueba que hubo contextos en que esposas de embajadores fueron valoradas por sí solas como agentes diplomáticos por encima de sus maridos. En este trabajo se ofrece un análisis detallado del caso, empezando por su contextualización en el entramado diplomático español en el París del momento, para después valorar las razones que condujeron tanto a su formulación por parte de la corte madrileña, como a su eventual abandono. Nuestras conclusiones enfatizan cómo la mezcla de asuntos familiares y de Estado condicionó la propuesta y cuestionan la distinción entre roles diplomáticos femeninos formales e informales.
Tras la muerte de la reina: los inventarios de ropas de María Luisa de Parma
Authors: Antúnez López Sandra
Published: December 2024

El presente trabajo pretende dar a conocer los distintos inventarios de ropas de la reina María Luisa de Parma. Las fuentes primarias consultadas revelan datos inéditos hasta el momento, que permiten analizar los diversos registros de prendas que tenía la monarca en su guardarropa. El primer documento realizado en 1808 se realizó una vez que Carlos IV y María Luisa se marchasen de la corte. Los inventarios y tasación post mórtem de 1819 y 1820 aportan que ropas vestía la soberana exiliada en Roma. Esta serie de documentación nos aproxima a los enormes gastos de vestuario que tuvo la soberana durante su reinado. El análisis de estos inventarios demuestra que compraba ingentes cantidades de indumentaria con el objetivo de controlar su propia imagen. A través de los distintos registros inventariados queda claro que la soberana solicitaba todo lo necesario para vestirse siguiendo la moda del momento. Todo ello ha sido posible a través del examen y valoración de los fondos documentales conservados en el Archivo General de Palacio de Madrid.
Calidad del servicio y la fidelidad de los estudiantes de Pregrado de la Facultad de Ciencias Administrativas, UNMSM, Lima
Authors: Almora Vargas Greta María
Published: December 2024

The quality of service is a fundamental axis in education, not only because of the greater demands that exist today, but also because of the exponential growth of the number of universities in the country, which makes them seek to meet the needs of their students so that they recommend their home or continue their studies. For this reason, the objective of this research was to find the relationship between the quality of service and the loyalty of undergraduate students of the School of Administrative Sciences of the Universidad Nacional Mayor de San Marcos (UNMSM). To achieve this, a quantitative, non-experimental, cross-sectional and correlational method was used, through a 28-question questionnaire applied to 328 students. In this study, it was found that 76.9% of the students perceived the quality of service as medium-low, and 81.1% of the students had medium-low loyalty to the university. In conclusion, a moderate and positive relationship was found between service quality and student loyalty, with quality of support, academic quality, and quality of career opportunities being the factors most related to loyalty.
Impacto de estrategias de marketing en la promoción de productos circulares: revisión sistemática
Authors: Camargo Hermosilla Raul Moisés
Published: December 2024

El objetivo de este artículo de revisión sistemática es evaluar la efectividad de las estrategias de marketing en la promoción de productos circulares. A través de un análisis exhaustivo de la literatura científica actual, se busca identificar las mejores prácticas de marketing para impulsar la adopción de productos circulares en el mercado, contribuyendo así al avance de la economía circular y el marketing sostenible. Este estudio destaca la importancia de las prácticas de marketing sostenible para influir en la percepción de los consumidores y fomentar la adopción de productos circulares. Para realizar esta revisión sistemática, se siguió el método PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), que establece pautas claras y rigurosas, garantizando la transparencia, reproducibilidad y calidad del proceso de revisión. Los resultados revelaron que las estrategias de marketing verde y circular son fundamentales en la transición hacia una economía más sostenible. En conclusión, este estudio subraya la importancia de integrar estrategias de marketing sostenible para promover la economía circular, ofreciendo una guía para futuras investigaciones y prácticas comerciales más sostenibles.
Evaluación psicométrica de la escala cultura financiera en estudiantes universitarios
Authors: Peñaloza Arana Eloyna Lucia , Loza Ticona Renzi Marilu , Arámbulo Ayala de Sánchez Marizol Candelaria
Published: December 2024

Objective: To evaluate the Financial Culture Scale as a psychometrically robust tool for measuring the key dimensions of financial culture in university students in Peru. Methods: A quantitative study was conducted, including the analysis of items through polychoric correlations and the examination of the internal structure and reliability of the instrument. Results: The validity (X²/gl = 3.65; CFI = 0.99; TLI = 0.99; SRMR = 0.03; RMSEA = 0.05; PNFI = 0.91) and reliability of the ESCF were demonstrated, with values exceeding 0.70 and an average variance extracted (AVE) greater than 0.50 in all all dimensions. Conclusion: The validity and reliability of the ESCF have been demonstrated, supporting its use as an effective tool in research. The findings indicate that the model fits the data, suggesting that the evaluated dimensions are consistent and relevant. This provides a solid foundation for future research and applications of the ESCF in various contexts, ensuring that the results are reliable and useful for informed decision-making.
Metonymy in climate change discourse by King Charles III: A cognitive-linguistic perspective
Authors: Kapranov Oleksandr
Published: December 2024

The current British monarch King Charles III is a staunch supporter of climate change mitigation (O’Neill et al. 2013, 413). Whereas he has delivered numerous speeches on climate change both domestically and internationally, currently, however, there are no studies that investigate his speeches on the issue of climate change through a linguistic lens in general and through a cognitive-linguistic prism in particular. Furthermore, there seems to be no published research on such a ubiquitous cognitive-linguistic device as metonymy (Hart 2011) in his speeches on climate change. In order to address the gap in scholarship, the article presents a study that aims to identify the types of metonymy in a corpus of speeches on climate change delivered by King Charles III. The corpus was analysed qualitatively by means of applying a cognitive-linguistic approach to metonymy developed by Radden and Kövecses (1999). The results of the corpus analysis revealed the presence of the following types of metonymy, namely (i) place for a climate change-related event, (ii) place for a climate change-related activity, (iii) place for the government involved in a climate change-related activity, (iv) the generic company name for an actor involved in a climate change-related activity, (v) the specific company name for an actor involved in a climate change-related activity, (vi) the defining property of the category “climate change actor” for the whole category, and (vii) the defining property of the category “climate change goals” for the whole category. The findings are further discussed and illustrated in the article.
A felnőtt korú cukorbetegek laboratóriumi vizsgálatainak elemzése hazánkban
Authors: Safadi Heléna , Lám Judit , Tislér András , Keresztes Katalin , Belicza Éva
Published: December 2024

Bevezetés: A cukorbetegség a csökkenő incidenciája ellenére
továbbra is jelentős terhet ró a hazai ellátórendszerre, ugyanakkor a gondozási
gyakorlatról szisztematikus, nemzeti szintű felmérés ez idáig nem készült.
Célkitűzés: A hazai cukorbeteg-ellátás elemzése a javasolt
laboratóriumi vizsgálatok elvégzésének mértéke alapján, a rendelkezésre álló,
adminisztratív adatok tükrében. Módszer: Kutatásunkat a Nemzeti
Egészségbiztosítási Alapkezelőnél 2010–2021 között rendelkezésre álló
igénybevételi adatokból végeztük. Retrospektív kohorszvizsgálattal elemeztük a
cukorbetegek gondozása során, a szakmai irányelvek alapján kivitelezendő
laboratóriumi tesztek elvégzési arányát 4 kohorszban 4 éves megfigyelési
periódusban, valamint többváltozós logisztikus regressziós elemzéssel tártuk fel
a tesztek elvégzését befolyásoló tényezőket. Eredmények: A
vizsgálatba 128 115 beteget vontunk be. Kicsivel több mint 70%-uknál a 4 év
során legalább 3 különböző évben történt vércukor- és szérumkreatinin-vizsgálat,
míg HbA1c-, vizeletglükóz- és vizeletketonteszt a betegek 50–60%-a
esetén valósult meg. Az első antidiabetikum-kiváltást követő 4 évben kevesebb
mint 30%-ban történt LDL-koleszterin-, illetve vizeletalbumin-vizsgálat. A
pandémia hatása tetten érhető a vizsgálati arányok csökkenésében 2020–2021-ben.
A tesztek elvégzésének kisebb a valószínűsége férfiak, a fiatalabb korcsoportok,
valamint a csak metformint és/vagy szulfanilureát szedők esetén. Az eredmények
időben romló tendenciát mutatnak. Megbeszélés: Az eredmények
rámutatnak arra, hogy szükség van a cukorbeteg-ellátás feladat- és felelősségi
köreinek pontosabb meghatározására, a laboratóriumi vizsgálatok megvalósulását
segítő informatikai eszközök, emlékeztetőrendszerek és elérhető kapacitások
biztosítására, illetve az érintett betegpopuláció ismereteinek fejlesztésére.
Kutatásunk limitációja, hogy az adatokból a labortesztek eredménye nem, csak
elvégzésük ténye ismerhető meg, és a magánellátásban, illetve a ’point-of-care’
módon végzett tesztek nem jelennek meg benne. Következtetés: A
hazai érvényes szakmai irányelv fényében, csak a kapcsolódó laboratóriumi
teszteket vizsgálva megállapítható, hogy a cukorbeteg-ellátás működésének és a
mögöttes adatszolgáltatásnak vannak fejlesztendő területei. Az integrált ellátás
kialakítása, a feladatok és a hatáskörök egyértelmű meghatározása, a
’point-of-care’ vizsgálatok és a laboratóriumi vizsgálatok eredményeinek
beemelése az adatszolgáltatásba jelentősen hozzájárulhat a hazai
diabetesgondozás fejlődéséhez. Orv Hetil. 2024; 165(52): 2047–2060.
Resilience in Adolescent Victims of Bullying: The Role of Emotion Regulation and Social Support
Authors: Subagio Naomi Aryandini , Virlia Stefani
Published: December 2024

Bullying experienced by adolescents has a negative impact, which necessitates the development of high levels of resilience to address and grow from traumatic experiences. Key influencing factors include emotion regulation and social support. Therefore, this study aimed to investigate the impact of two emotion regulation strategies and social support on resilience of adolescent victims of bullying. This was a quantitative study with a correlational design, involving 612 adolescent victims of bullying aged 13-15 years from junior high schools in Surabaya. The results showed a significant effect (p
The Marine Actinobacterium Streptomyces sp. BTA 1-131 as a Potential Producer of Anti-Nontuberculous Mycobacterial (Anti-NTM)
Authors: Paramita Ni Luh Putu Vidya , Atikana Akhirta , Sukmarini Linda , Untari Febriana , Prayoga Muhammad Bagas , Maulidia Faiqoh Nur , Ratnakomala Shanti , Lisdiyanti Puspita , Nuryastuti Titik , Hertiani Triana
Published: December 2024

Nontuberculous mycobacteria (NTM) are environmental microorganisms, also known as opportunistic pathogens, found in patients with pulmonary tuberculosis. The emergence of antibiotic resistance is increased by prolonged antibiotic treatment for NTM infections. Therefore, alternative sources of new antibiotics are essential for the treatment of NTM infections. A marine actinobacterium, Streptomyces sp. BTA 1-131, isolated from a marine sponge, Melophlus sarasinorum, has been reported as a potential source of antibacterials and anticancer agents. The present study aimed to investigate the potential of Streptomyces sp. BTA 1-131 against two NTMs: Mycobacterium smegmatis and Mycobacterium fortuitum. Streptomyces sp. BTA 1-131 was fermented in three cultivation media (SYP, ISP2, and YS), and the secondary metabolites were extracted using methanol. The bioactivity screening showed inhibition of all methanolic extracts against the growth of M. smegmatis and M. fortuitum. The methanolic extract, which could inhibit both mycobacteria, was a crude extract derived from SYP liquid medium fermentation. The isolated compounds in this study were preliminarily identified using thin-layer chromatography (TLC). The TLC results showed different potential compounds in the crude extracts of Streptomyces sp. BTA 1-131 also highlighted the impact of the fermentation medium on the production of metabolites from Streptomyces. This study also added knowledge about the importance of the Indonesian marine actinobacterium Streptomyces sp. BTA 1-131 as a promising producer of anti-NTM compounds.
Design of non-covalent dual-acting inhibitors for proteases MPRO and PLPRO of coronavirus SARS-CoV-2 through evolutionary library generation, pharmacophore profile matching, and molecular docking calculations
Authors: Yevsieieva Larysa , Trostianko Pavlo , Kyrychenko Alexander , Ivanov Volodymyr , Kovalenko Sergiy , Kalugin Oleg
Published: December 2024

The proteases of the SARS-CoV-2 coronavirus are crucial for the virus's life cycle, making them a prime target for developing antiviral drugs to combat COVID-19. Currently, there is a priority to develop new antiviral drugs that can target multiple viral proteins at once. In this study, we analyze the molecular mechanisms of how non-covalent inhibitors interact with the main protease (Mpro) and papain-like (PLpro) protease of SARS-CoV-2 to create a computer modelling algorithm for discovering ligands that can inhibit both Mpro and PLpro simultaneously.
Aim of the study. We aim to analyze the molecular structures involved in the interactions between current non-covalent inhibitors and the Mpro and PLpro proteases of SARS-CoV-2. The goal is to identify a common molecular structure that could be used to discover new inhibitors with a dual-acting mode using computer simulations.
Materials and Methods. LigandScout 4.5 software was used for 3D-pharmacophore analysis, virtual screening and molecular docking. AutoDock Vina 1.1.2 tools was utilized for molecular docking. Web-servers PLIP (Protein-Ligand Interaction Profiler) and Pharmit were used for studying molecular binding mechanisms. Generation of evolutionary libraries was performed by DataWarrior 6.0. Analysis and visualization were performed by Discovery Studio 2024 Suite.
Results. Our study analyzed various models of SARS-CoV-2 protease binding sites available in the Protein Data Bank (PDB) and their corresponding non-covalent inhibitor ligands. This analysis helped identify important features of the Mpro and PLpro ligands. By comparing the pharmacophore models of Mpro ligands with the structural features of PLpro inhibitors, we identified ligands that could potentially match the binding sites of both proteases. Using the structures of these ligands, an evolutionary library was created in the DataWarrior program. Virtual screening of this library using both Mpro and PLpro pharmacophores revealed several new hit molecules. Molecular docking of these molecules into the active sites of the Mpro and PLpro proteases and calculating their binding energetics led to the identification of several molecules and their corresponding scaffolds with dual inhibition potential. These findings can be further studied in vitro with the aim of discovering drugs for COVID-19.
Conclusions. We used computer-based screening to search for ligands that could bind to both Mpro and PLpro proteases. After identifying these potential compounds, we developed synthesis methods to obtain them for further in vitro biological activity studies
Foreign experience of software testing engineers training: analysis of educational standards and programs of European universities
Authors: Gura Oleksandr
Published: December 2024

The article explores the European educational system's approach to training software testing specialists. It contains an analysis of certain key standards for IT engineers training in Europe, such as the Standards and Guidelines for Quality Assurance in the European Higher Education Area (ESG), the European Association for Quality Assurance in Higher Education (ENQA) criteria, and national accreditation standards like the Polish Accreditation Committee (PKA), the German Accreditation Council (GAC), and the UK’s Engineering Council (ECUK). The study emphasizes the place and teaching methods of software testing theory and practice within university curriculum guidelines, assessing both an availability of dedicated testing disciplines and the appearance of testing topics/modules in more general engineering disciplines. Despite similar interpretations of basic concepts and practices in software testing, opinions on teaching methodologies and the representation of both theoretical and practical aspects of it vary among the reviewed standards. Additionally, the research examines training programs at leading European universities to identify how software testing and quality assurance are reflected in their curricula. This analysis covers full-time training programs for students in computer science, software engineering, and related fields. The study explores programs in both general and basic disciplines within IT and those specific to certain technological or organizational areas, such as mobile device development or IT project management. The content of subjects, modules, lectures, and extracurricular work tasks available in open sources was also analyzed. Furthermore, the research investigates how these institutions incorporate practical training, such as internships and project-based learning, to ensure students gain hands-on experience in software testing and quality assurance
Expanding the absorption bandwidth with two-layer graphene metamaterials in gigahertz frequency range
Authors: Viet Ngo Nhu , Lam Vu Dinh , Tung Bui Son , Khuyen Bui Xuan , Son Pham Thanh , Anh Nguyen Hai , Hai Nguyen Phon , Tung Do Khanh , Chi Do Thuy
Published: December 2024

This work investigates the design and performance of a bilayer graphene metamaterial absorber operating in the GHz region. We initially analyzed a single-layer metamaterial absorber composed of a conductive ink graphene structure on a FR-4 dielectric substrate backed by a continuous copper sheet. Subsequently, a second graphene-FR4 layer of identical dimensions was added to create a bilayer structure. While the number of absorption peaks increased, they remained isolated, failing to achieve the desired broadband effect. To overcome this limitation, we explored graphene layers with varying surface resistances. Our findings demonstrate that the bilayer graphene metamaterial absorber achieves an absorption exceeding 90% with a remarkable bandwidth of 9.1 GHz, spanning frequencies from 6.21 GHz to 15.31 GHz. This significant bandwidth expansion is attributed to the synergistic interactions and contributions between the graphene and metal layers within the structure. To gain a deeper understanding of the underlying absorption mechanism, we investigated the surface current distribution, the impact of conductivity, and the individual contributions of each layer. Additionally, we examined the influences of both incident angle and polarization angle on the absorption performance of the proposed bilayer MA. These comprehensive analyses provide valuable insights into the mechanisms responsible for the enhanced absorption observed in multilayer metamaterial structures. Our work holds relevance and might be useful to develop electromagnetic wave shielding technologies and devices operating in the GHz frequency range.
Contact Lens Discomfort (CLD) Treatment with MY MASK Light Modulation® LED mask
Authors: Pavan Michielon Enrico , Gheller Pietro , Pinero David , Stanco Luca
Published: December 2024

The purpose of this study was to understand how the use of the light modulation LED mask MY MASK affects Contact Lens Discomfort (CLD).
Forty-two (42) soft contact lens wearers with dry eye symptoms were recruited for a 3-week descriptive observational study. Treatment using the light modulation LED mask was applied three times, each lasting 15 minutes; on day 1, day 3 and after one week. Symptoms of CLD were quantified with the help of a specific questionnaire (CLDEQ-8) before and after treatment. Ocular surface and tear film measurements were conducted at baseline and 1 week after the last treatment.
Visual acuity remained stable (0.00 LogMAR ± 0.10). The number of symptomatic contact lens wearers decreased by 43% (18 out of 42 subjects), as indicated by the CLDEQ-8 scores (t−test=5.14; p < 0.001) (R2=0.218). Non-invasive tear film breakup time (NIBUT) improved significantly. Before treatment, 70% of eyes (59 out of 84) showed a NIBUT of less than 10 s; after treatment, 26% had values below this cut-off (t-test=3.06; p=0.001) (R2=0.241). Meibography values did not change (t-test= 1.17; p= 0.121) (R2 = 0.872). TearScope showed considerable improvement in tear film lipid layer thickness and the data obtained through the Gland Evaluator also demonstrated an improvement.
Treatment using light modulation LED mask could be an interesting option in improving the aspects that characterise CLD. Additional research is required to establish the reliability of the observed improvement and investigate the necessity of repeated treatments as a means of stabilising or sustaining satisfaction in contact lens wearers.
Теоретичні аспекти дослідження інноваційно-інвестиційного розвитку підприємств в умовах глобальної турбулентності та невизначеності
Authors: Лизогуб Андрій
Published: December 2024

У статті досліджено теоретичні засади інноваційно-інвестиційного розвитку підприємств в умовах глобальної турбулентності та невизначеності. Проаналізовано сучасні підходи до визначення понять "інноваційний розвиток" та "інвестиційний розвиток", встановлено їх взаємозв'язок. Розглянуто вплив глобальних викликів на інвестиційну активність та інноваційну діяльність підприємств. Систематизовано фактори зовнішнього та внутрішнього середовища, що створюють турбулентність у діяльності підприємств. Проаналізовано взаємозв'язок між інноваційними процесами та інвестиційним забезпеченням в умовах нестабільності. Визначено ключові фактори впливу на ефективність інноваційно-інвестиційного розвитку підприємств в період глобальної турбулентності. Досліджено механізми адаптації підприємств до умов невизначеності через їх інноваційно-інвестиційну діяльність. Запропоновано підходи до формування стратегії інноваційно-інвестиційного розвитку з урахуванням факторів ризику. Обґрунтовано необхідність створення гнучкої системи управління інноваційно-інвестиційним розвитком підприємств.
Social and economic consequences of digitalization: problems and opportunities
Authors: Маркова Тетяна , Волкова Анастасія , Пчелянська Гаїна , Володіна Олена
Published: December 2024

The article examines the consequences of digitalization in the sphere of socio-economic space. Opportunities and risks in various areas from the use of digital technologies have been determined. It has been defined that the field of employment and various professions are subject to transformational processes in connection with the robotization of production processes. With the help of information and communication technologies, the field of education was able to continue its activities and be continuous in the conditions of unpredictable influences, make the educational process mobile, differentiated, individual and adapted to the realities of today. Artificial intelligence has already become a part of everyday life in many countries. And digital transformation manifests itself not only in the use of a computer or in the simple automation of routine functions, digitalization is a new form of doing business and reworking the usual corporate procedures. It has been determined that during the introduction of quarantine measures around the world, people switched to online banking quite quickly. As a result, banks sensed the interest and need of customers for this type of service and began to more actively transform more and more types of financial transactions into an online format. For the effective digitalization of the economic sphere, it is necessary to define the basic principles according to which it will be possible to build a strategy for the implementation of digital tools in various spheres of the population's life.
Grain Storage Forum
Authors: Agro Pro
Published: December 2024

31 січня 2025 року відбудеться GRAIN STORAGE FORUM – найбільший в Україні форум в галузях зберігання, переробки, логістики і трейдингу агропродукції.
Edge AI for Real-Time Decision Making in IOT Networks
Authors: Chinta Swetha
Published: December 2024

The proliferation of Internet of Things (IoT) devices and networks has led to an exponential increase in
data generation at the network edge. Processing this data in real-time to enable rapid decision making presents
significant challenges for traditional cloud-centric architectures. Edge AI, which involves deploying artificial
intelligence algorithms directly on edge devices and gateways, has emerged as a promising solution to enable lowlatency analytics and decision making in IoT networks. This paper presents a comprehensive review and analysis of
Edge AI techniques for real-time decision making in IoT environments. We examine the key components, algorithms,
and architectures for Edge AI systems, as well as the challenges and opportunities in this rapidly evolving field.
Through extensive experiments and case studies, we demonstrate how Edge AI can significantly improve response
times, reduce bandwidth usage, enhance privacy, and enable new IoT applications across multiple domains including
smart cities, industrial IoT, and autonomous systems. Our results show that Edge AI can reduce decision-making
latency by up to 90% compared to cloud-only approaches while maintaining comparable accuracy. We conclude by
discussing future research directions and the potential impact of Edge AI on the continued growth and evolution of IoT
networks.
Türk Soylulara Türkiye Türkçesi Öğretimi Alanında Yapılan Çalışmalar Üzerine Bir Değerlendirme
Authors: Barcın Sibel
Published: December 2024

Türk soylulara Türkiye Türkçesi öğretimi üzerine yapılan araştırmalar, dil öğretimindeki farklı yaklaşımları ve uygulamaları anlamak bakımından önem taşımaktadır. Bu çalışmalar, öğretimi geliştirmek için veriler sunmaktadır. Bu alandaki mevcut bilgilerin derinlemesine incelenmesi, eğitim stratejilerinin daha etkili hâle gelmesine katkı sağlayabilmektedir. Bununla birlikte farklı yöntemlerin ve uygulamaların karşılaştırılması, daha etkili öğretim yöntemlerinin belirlenmesine olanak tanımaktadır. Bu bağlamda araştırmanın amacı Türk soylulara Türkiye Türkçesi öğretimi üzerine yapılan çalışmaları incelemektir. Mevcut literatürün kapsamlı bir şekilde incelenmesi amacıyla doküman analizi tekniği kullanılmıştır. Araştırma çerçevesinde Türk soylulara Türkiye Türkçesi öğretimine ilişkin yazılmış makaleler veri kaynağı olarak seçilmiş ve bu makalelerin belirlenmesinde ULAKBİM tarafından oluşturulan TR Dizin’de taranan dergiler temel alınmıştır. TR Dizin platformunda 01.08.2024 tarihine kadar yayımlanmış olan makaleler değerlendirilmiştir. İncelemeye alınan araştırmalar 2009-2024 yılları arasında yayımlanan çalışmalarla sınırlandırılmıştır. Tarama sonucunda toplam 65 makale incelemeye alınmış ve bu makalelerden 34’ü araştırmanın amaçları doğrultusunda analiz sürecine dâhil edilmiştir. Yapılan içerik analizi sonucuna bakıldığında katılımcı grubun büyük çoğunluğunu lisans, TÖMER ve dil hazırlık sınıflarındaki öğrencilerin oluşturduğu tespit edilmiştir. Bununla birlikte tek yazarlı makalelerin daha çok yer aldığı, makalelerin en çok 2020 yılında yayımlandığı, daha fazla yazma becerisi üzerine çalışmalar yapıldığı, yöntem olarak daha fazla nitel seçildiği anlaşılmıştır. Ayrıca veri toplama aracı olarak öğrenci yazılı ürünlerinin ön plana çıktığı görülmüş ve ana dilinin hedef dilde konuşmaya ket vurması en fazla ulaşılan sonuç görünümü olarak belirlenmiştir. Bu nedenle incelenen çalışmalarda, daha çok öğrencilerin hatalarına odaklanıldığı saptanmış ve bu hataların düzeltilmesine yönelik önerilere de ağırlık verildiği gözlemlenmiştir. Sonuç olarak bu araştırma Türk soylulara Türkiye Türkçesi öğretimi konusundaki literatürü analiz ederek bu alandaki araştırmalara ve uygulamalara yönelik bir bakış açısı sunmayı amaçlamaktadır.
Stability of uniform rectilinear motion of a tractor with two trailers
Authors:   Peter the Great St. Petersburg Polytechnic University, Smirnov Aleksey S. ,   Institute of Problems of Mechanical Engineering of the Russian Academy of Sciences, Degilevich Egor A. ,   Institute of Problems of Mechanical Engineering of the Russian Academy of Sciences; CMT-Engineering
Published: December 2024

This paper investigates the stability of uniform linear motion of a tractor followed by two identical single-axle trailers. It is shown that in addition to the articulated connection of the first trailer with the tractor and the second trailer with the first one, the mechanical compliance of each coupling should be taken into account when identifying the conditions of motion stability for the system. The Appel equations are used to develop a mathematical model of the motion of the system with two nonholonomic constraints in a linear formulation. Dimensionless problem parameters, dimensionless generalized coordinates, and dimensionless time are introduced to represent the mathematical model in the most compact and convenient form. By analyzing the characteristic equation of the sixth order using the D-decomposition method and the Lienard-Chipard criterion, the stability motion regions are constructed on the plane of two dimensionless parameters for different values of the other two dimensionless parameters. The obtained data are compared with the solution of the motion stability problem for a tractor with one trailer. The results allow determining the qualitative and quantitative features of the derived solution. The conclusions drawn in this paper are of interest not only from a theoretical point of view, but can also be useful for practical applications.
Simulation of an electromagnetic in-bore projectile velocity sensor for a high-speed ballistic cannon
Authors:   Tomsk State University, Bimatov Vladimir I. , Mekhanich Аlina А. ,   Tomsk State University, Sinyaev Sergey V. ,   Tomsk State University, Yashchuk Aleksey A. ,   Tomsk State University
Published: December 2024

The design is described, and a mathematical model is developed for the operation of the measuring frames of a speed sensor for a projectile when it moves within a bore or behind its muzzle. In measuring sections, the frames generate magnetic fields that act as magnetic barriers for the projectiles. The operating principle is based on the effect of deformation of the magnetic field of the barriers due to the electrically conductive projectile. The magnetic circuit of the frame includes an open magnetic core with measuring coils, a coil generating a constant magnetic field (or a permanent superimposed magnet), and a protective cap made of durable nonmagnetic metal with high resistivity. The mathematical model takes into account the 3D interaction of the projectile with the magnetic field of the barrier and the effect of induction currents in the protective cap on the magnitude and shape of the signals. The results of parametric studies on the effect of the speed, shape, and size of the projectile bodies, as well as the main parameters of the measuring frames, on the magnitude and shape of the signals generated by the projectile are presented.