bluuebunny/crossref_metadata_2025 huggingface dataset:
Main mechanisms of central nervous system damage with combined infection of HIV and SARS-COV-2: review
Authors: Rassokhin V. V. , Svetashova E. I. , Modestova I. О. , Kaplevskaya N. V. , Belyakov N. А.
Published: April 2023

OBJECTIVE: Assess the degree of elaboration regarding mechanisms of the nervous system damage in HIV infection to further evaluate SARS-CoV-2, as a possible contributing factor in emergence and worsening psycho-neurological pathology in HIV-infected patients. MATERIALS AND METHODS: The analytical review was conducted using the medical database PubMed. More than 20 domestic and 30 foreign publications were studied on the mechanisms of the nervous system damage in HIV infection and SARS-CoV-2 between 2019-2022.Some preliminary study was conducted. Outpatient charts data of 146 HIV-infected patients were analyzed; a confirmed diagnosis of COVID-19 mild or moderate form (between 2020-2022) appeared in 42 (25,8%) cases (1st group). The comparison group (2nd group) included 40 patients without HIV infection, but suffered COVID-19, who were surveyed after signing voluntary informed consent. The survey data provided insight into the frequency and severity of neuropsychiatric manifestations and their possible connection with COVID-19. RESULTS: The high neuroinvasive and neurotropic HIV potential was demonstrated and implemented in a variety of ways and mechanisms that manifests in clinical practice by the appearance of diverse neuropsychiatric symptomatology. The study proved the influence of HIV infection on ACE-2 receptor expression by neurovascular cells (NVC) and also revealed some other features, contributing to the potentiation of SARS-CoV-2 invasion in CNS. The results of the preliminary study showed that in the group with HIV-infected 9 patients (21,4% of recover from COVID-19) experienced long-term neuropsychiatric manifestations after coronavirus infection, while all patients had long-term suppressed HIV viral load against the backdrop of regular ARV therapy and satisfactory immune status (CD4+ T-lymphocytes count). In the group without HIV infection after COVID-19 22 (55%) patients experienced neuropsychiatric complications, estimated by them as “extremely strong”. DISCUSSION: Although the study did not reveal a clear link between the presence of immunodeficiency in HIV infection and manifestation of neuropsychiatric pathology after COVID-19, further research is needed to define mutual influence of HIV and SARS-CoV-2 on the emergence of neuropsychiatric pathology. CONCLUSION: Considering a lack of research, where the results obtained could reliably confirm increased risk of complications from the nervous system, caused by SARS-CoV-2 against the backdrop of the existing HIV infection, there is reason to believe that this problem remains relevant today. This dictates the need to examine closely neurological status in patients of this category and monitor neurological complications.
Rational decompression using computer programs
Authors: Yarkov A. M. , Bychkov S. A. , Fokin S. G.
Published: April 2023

Divers use tables with decompression modes when conducting diving descents. Currently, tables are being replaced by underwater computers, into which modern mathematical models of decompression algorithms are programmed. None of the existing models takes into account the individual characteristics of the organism, the processes occurring in the body under conditions of high pressure of the gas and water environment, and does not describe the real processes well enough. Modern diving computers are able to supply a diver with a large amount of information. Based on data on depth, time, number of dives and time of surface intervals, they help to plan dives, inform when it is necessary to make an ascent, assign, if necessary, safety stops and calculate the time before the flight by plane. Currently, it is safe to say that a computer is simply necessary for a diver. His health, and sometimes his life, depends on it.
Narrativas em disputa sobre a loucura: da (re)produção discursiva sobre a periculosidade aos agenciamentos das internas em manicômios judiciários no Pará e no Distrito Federal
Authors: Levy Beatriz Figueiredo , Silva Erica Quinaglia , Braga da Rocha Wesley
Published: April 2023

A partir de uma abordagem comparativa, este estudo investigou a realidade das mulheres submetidas a uma medida de segurança no Pará e no Distrito Federal. Para tanto, foi realizada uma etnografia de e em documentos concernentes aos processos de (re)produção discursiva que conduziram às concepções estigmatizadas sobre a relação entre as mulheres e a loucura. Os documentos acessados foram os processos judiciais, laudos psiquiátricos e relatórios psicossociais que retratam as internações e os agenciamentos dessas mulheres no Hospital Geral Penitenciário do Pará e na Ala de Tratamento Psiquiátrico do Distrito Federal. Atentou-se, sobretudo, para a problematização das narrativas sobre a periculosidade atribuída a elas, bem como para as disputas entre os poderes-saberes jurídico e psiquiátrico na gestão dos corpos femininos tidos como desviantes.
Uma basílica grande e bela como o Brasil: a fabricação de um catolicismo monumental
Authors: Godoy Adriano
Published: April 2023

Neste artigo, a monumentalidade arquitetônica da Basílica Nacional de Nossa Senhora Aparecida (Aparecida, São Paulo, Brasil) é analisada através das suas dimensões religiosas, estéticas e políticas. Tendo como referências documentos, imagens e pesquisas de campo sobre os processos de construção desse templo, são explorados os modos pelos quais o catolicismo brasileiro busca materializar uma nova forma de presença pública no imaginário nacional. Em uma parceria da Igreja Católica com o Estado na busca de uma modernidade católica pautada pela tradição arquitetônica, argumento que o tamanho colossal do edifício se firma como o principal referencial estético de brasilidade na sua fabricação enquanto um monumento nacional.
Seguindo controvérsias em procedimentos regulatórios: o caso da cannabis no Brasil (2014-2019)
Authors: Caetano Hellen
Published: April 2023

Os procedimentos regulatórios no Brasil têm sido acompanhados por instituições regulatórias que desempenham papéis específicos e estabelecem o modo como profissionais e a população devem lidar com substâncias. O objetivo desse artigo é descrever as controvérsias em torno dos procedimentos regulatórios com Cannabis e seus derivados no Brasil entre 2014 e 2019. A discussão em questão é composta por diferentes atores, como substâncias, pacientes, ativistas e instituições. Neste trabalho evidencio o papel de instituições como a Agência Nacional de Vigilância Sanitária (Anvisa) e o Conselho Federal de Medicina (CFM) a partir dos documentos produzidos por eles. O material recolhido foi sistematizado e analisado no programa de análise qualitativa Atlas.ti a partir de codagem de dados, o que permitiu traçar aproximações e dissidências entre os documentos, além de permitir a comparação entre os discursos públicos de representantes dos órgãos e as fontes escritas. Os usos e estatutos da Cannabis foram construídos a partir de suas posições ambíguas como uma “droga” e um “medicamento”. A partir de uma etnografia da documentação, constato que a Anvisa e o CFM assumem posicionamentos que vão além de seu caráter estritamente técnico. Suas atuações se constituem a partir de vieses políticos ao imputar mecanismos de controle burocrático que constroem e reafirmam suas posições como autoridades em saúde.
A sociedade junto ao Estado: política indígena, voto e eleições
Authors: Rufino Marcos Pereira
Published: April 2023

O livro explora a ampla gama de situações enfrentadas pelos indígenas do Brasil, da Colômbia, do Peru, da Argentina, do México e do Equador na tentativa de penetrar as estruturas políticas de representação não indígenas - especialmente os processos eleitorais no âmbito municipal. A grande maioria dos trabalhos são de natureza etnográfica e alguns outros se apoiam na análise estatística de dados eleitorais e no diálogo com as teorias do voto e processos eleitorais. Ao longo da obra, os vários autores elencam os principais obstáculos e dificuldades que devem ser superados por essa forma de política indígena, exploram o diálogo com uma incipiente antropologia voltada ao estudo do voto, das eleições e dos partidos políticos e, por fim, destacam a importância de uma perspectiva multidisciplinar no estudo do fenômeno.
Apresentação: Novos olhares antropológicos sobre comida
Authors: Benemann Nicole , Sordi Caetano , Menasche Renata , Collaço Janine
Published: April 2023

Como fato social total, a alimentação é um fenômeno complexo que articula diferentes dimensões da experiência humana em múltiplos níveis técnicos, éticos, estéticos, políticos e classificatórios. O dossiê reúne um conjunto de trabalhos sobre a comida e o comer em distintos contextos socioculturais, privilegiando os estudos de caráter etnográfico. Nesta apresentação, reiteramos a importância da alimentação e seus processos de produção, preparação, distribuição e consumo como objetos de investigação antropológica; delineamos pontos de contato entre a antropologia da alimentação e perspectivas teóricometodológicas emergentes na disciplina; e destacamos as contribuições das autoras e autores do dossiê para a continuidade e a renovação de debates clássicos e contemporâneos na pesquisa sobre alimentação.
Hallazgos de violencia obstétrica en los centros de salud de Costa Rica: investigación basada en un análisis de percepciones de mujeres usuarias de la CCSS
Authors: De la Garza-Jiménez Ana Lorena
Published: April 2023

Este artículo presenta las experiencias de diez mujeres entre los 15 y 19 años que sufrieron violencia obstétrica en los centros de salud de Costa Rica, entre los años 2007 y 2020. Para alcanzar el objetivo se utilizó una metodología cualitativa-exploratoria, en la que se aplicó una encuesta con entrevistas a profundidad, cuyo propósito fue analizar las percepciones y visiones de las mujeres en torno a la atención del embarazo, parto y postparto. El análisis se realizó a la luz de los derechos humanos y el parto humanizado, la violación del derecho a la salud y a la vida, al no recibir información clara y oportuna, no respetar su privacidad y el trato no humanitario; escenarios invisibilizados por factores sociales, culturales y educativos. Entre los hallazgos descubiertos, se observa que el Estado de Costa Rica –desde el sistema de salud y su personal sanitario– debe examinar las prácticas estructurales desarrolladas en la cotidianidad institucional. Las conclusiones llaman a la reflexión sobre la necesidad de reeducar al personal sanitario, para que se implementen acciones que modifiquen las conductas que perjudican la salud física, emocional, psicológica y social de las mujeres. La atención del parto humanizado debe ejecutarse desde el ejercicio de los derechos humanos, en las unidades de atención institucional pública y privada.
Endocervical crypt involvement by high-grade cervical intraepithelial neoplasia and its association with high-grade histopathological recurrence after cervical excision in women with negative excision margins: a systematic review and meta-analysis
Authors: Papoutsis Dimitrios , Underwood Martyn , Parry-Smith William , Tzavara Chara
Published: April 2023

Background: There is a growing body of evidence suggesting that
endocervical crypt involvement by high-grade cervical intraepithelial
neoplasia (CIN) may represent a risk factor for disease recurrence after
cervical treatment. Objectives: To provide a systematic review
and meta-analysis on whether endocervical crypt involvement by
high-grade CIN on the excised cervical specimen is associated with
high-grade histopathological recurrence during the follow-up of women
after cervical excisional treatment. Search Strategy: We
searched the Medline, Scopus, Central and Clinical Trials.gov databases
from inception till June 2021. Selection Criteria: Studies that
reported on women with a single cervical treatment with any method of
excision for CIN2 or CIN3 lesion, negative excision margins and whose
recurrence was defined histopathologically were included. Data
Collection and Analysis: Two reviewers independently evaluated study
eligibility. We used the fixed effects model for meta-analysis.
Main Results: There were 4 eligible studies included in the
present systematic review that evaluated 1088 women treated with either
large loop excision of the transformation zone (LLETZ) or with cold
knife conization (CKC). The between study heterogeneity was not
significant. We found no significant association of endocervical crypt
involvement by CIN2-3 with high-grade histopathological recurrence at
follow-up after cervical excision (OR:1.93; 95%CI:0.51-3.35). The
subgroup analysis of women with LLETZ cervical excision showed again no
significant association with high-grade histopathological recurrence at
follow-up (OR:2.00; 95%CI:0.26-3.74). Conclusions:
Endocervical crypt involvement by high-grade CIN does not seem to be a
risk factor for high-grade histopathological recurrence after cervical
excision with negative excision margins.
Stochastic Unit Commitment Based on Energy-intensive Load Participating in Wind and Solar Power Consumption
Authors: Qian Liang , Lin Shunfu , Zhou Bo , Wang Wei , Bian Xiaoyan , Li Fangxing (Fran) , Li Dongdong
Published: April 2023

The fluctuation and intermittency of the wind and solar power outputs
results in the regulation pressure of thermal units in power systems.
The adjustable energy-intensive loads (such as the Electrolytic
aluminium and Steel plants) have great potentialities to participate in
demand response (DR) programs. This paper proposes an optimal scheduling
method of the unit commitment (UC) with the consideration of the
energy-intensive loads participating in wind and solar power
consumption. It adopts the nonparametric kernel density estimation
method to model the wind and solar power outputs. And then it uses
Frank-Copula function to describe the correlation between the scenarios
of wind and solar power outputs. A stochastic unit commitment (SUC)
model introduces chance constrained theory of the reserve coefficient to
describe time-variant scenarios, on the basis of the deviation between
the typical and simulative scenarios. The simulation results based on
IEEE 118-bus system shows that the energy-intensive load in the SUC
model can flexibly adjust and respond to the change of wind and solar
power output, reduce the impact of wind and solar power output’s
uncertainty and promote the consumption of wind and solar power.
Cyclophosphamide induced Pneumonitis in patients receiving dose dense chemotherapy for early breast cancer. A case series and review of the literature.
Authors: Kirwin Brendan , Saghaie Tajalli , Ing Alvin , Hasovits Csilla , Marx Gavin
Published: April 2023

Cyclophosphamide induced pneumonitis is a rare adverse event in patients
receiving adjuvant chemotherapy for breast cancer. It has been
infrequently reported in the literature and based on the described cases
it appears to be associated with dose dense regimens. We report three
cases of cyclophosphamide induced pneumonitis who were treated at our
centre. Our cases illustrate that careful attention must be paid to
timing of symptoms to ensure the correct causative chemotherapy agent is
identified so that potentially curative agents in the chemotherapy
regime are not omitted.
Mycoplasma pneumoniae pneumonia associated with pulmonary embolism and necrotizing pneumonia
Authors: Wang Chenlu , Li Lanxin , Xiao Gang , Chen Yuanyuan , Wang Yingshuo , Chen Zhimin , Zhou Yunlian
Published: April 2023

Background: This study aimed to explore the clinical
characteristics and management of mycoplasma pneumoniae pneumonia (MPP)
combined with pulmonary embolism (PE) in children and gain a better
understanding of the diagnosis treatment and prognosis of the disease.
Methods: We retrospectively reviewed the medical records of 16
children who were diag-nosed with MPP associated with PE and NP between
Janunary 2016 and Janunary 2023 at Children’s Hospital, Zhejiang
University School of Medicine. Results: All of the cases were
diagnosed with refractory mycoplasma pneumoniae pneum-onia (RMPP) and
complicated with necrotizing pneumonia(NP). The ages of the patients
ranged from 5.3 to 11.5 years old. The main manifestations were cough
and fever（n=16, 100%）,chest pain (n=8, 50%) , shortness of
breath(n=8,50%), hemoptysis (n=4, 25%). Among them, the pulmonary
artery was involved in 12 patients, including 6 cases on the right, 4
cases on the left, and 2 cases on both sides. Besides, the pulmonary
vein was suffered in 3 patients. Furthermore, Pulmonary artery and
pulmonary vein were involved in 1 patient. The mean D-dimer level was
8.50±4.76mg/L. All patients underwent anticoagulant therapy. After
treatment, all patients ’s symptoms were improved, and the lung lesions
were significantly improved. Conclusion: For children with
RMPP, PE and NP should be considered when chest pain, hemoptysis or high
level of d-dimer are present. Chest enhanced CT scan should be
perf-ormed as soon as possible, and anticoagulation should be treated
once the diagnosis of PEis confirmed. The long-term prognosis of PE was
favorable after the timely administrationof anticoagulant therapy.
Establishment of a measurement system to evaluate breast milk transfer of biological agents using dry filter paper: a multi-institutional study
Authors: Saito Jumpei , Yakuwa Naho , Hosokawa Yoshihiko , Hamada Hiromi , Suzuki Tomo , Sago Haruhiko , Kaneko Kayoko , Yamatani Akimasa , Murashima Atsuko
Published: April 2023

Aims Information on breastfeeding and the safety of biologics in infants
is lacking due to difficulties in case collection. We evaluated a method
for determining the concentration of biologics in breast milk using a
dry filter method that can simplify the collection, storage, and
transport of breast milk. Methods To generate dried filter paper (DFP)
samples, approximately 30 L of breast milk was placed onto a Whatman
903 card and punched out. After extraction, the supernatant was measured
using an enzyme-linked immunosorbent assay. Three concentrations of each
drug were prepared in liquid breast milk (LBM) and DFP samples for
stability testing, which confirmed that samples were stable up to 28
days after storage at 2–8 ºC or -20 ºC for LBM and at 25±5 ºC for DFP.
LBM and DFP samples were provided by lactating mothers using biologics
during lactation. Drug concentrations were compared. Results Breast milk
was provided by 12 lactating mothers (tocilizumab, n=4; abatacept, n=2;
etanercept, n=1; golimumab, n=1; sarilumab, n=1; and belimumab, n=3).
The accuracy and precision of measurements for the six drugs were within
acceptable limits. After 28 days, concentrations remained at more than
90% under all storage conditions. The quantitative values of the
provided LBM and DFP samples were similar. The maximum relative infant
dose ranged from 0.09% to 1.12%, which was an acceptable range.
Conclusion A method for determining the concentration of biologics using
DFP is expected to help improve pharmacotherapy for lactating women.
Molecular epidemiology of Human Adenovirus in Asturias (2011–2023)
Authors: melon Santiago , Alvarez-Arguelles Marta , Alba José María González , Rojo Susana , Boga Jose , Pérez-Martínez Zulema , Gómez-deOña Costanza , Ochoa-Varela Cristina , Rodríguez-Pérez Mercedes
Published: April 2023

Human Adenoviruses (HAdV) are implicated in multiples pathologies
causing mild to severe disease. The predominant genotypes detected in
association with disease differ among different countries or regions,
and change over time. In Spain and elsewhere little is known about the
molecular epidemiology of HAdV. From a total of 250 HAdV, members of
five species were present: A (1), B (126), C (87), D (27) and E (9). The
most found genotypes were B3 (119), C2 (48), C1 (29) and D8 (26).
Genotypes E4, C5, C6, B7, A31, B35 and D56 were also detected. HAdV
diversity increases over the years until the B3 genotype displaces all
other types in 2016 and 2023. HAdV detected in Asturias were similar to
those already described in other countries, no new local genotype were
observed. Genotypes 1-7 were more frequent in children under 15 years of
age, while types 8-56 were more frequent in the elderly. Multiple HAdV
introductions must have occurred given that only small transmission
clades can be inferred. The diversity of the epidemic increased with the
years until it disappeared one year periodically .The COVID-19 epidemic
accelerated the loss of diversity suggesting that interventions during
the pandemic were able to reduce HAdV transmission.
Population Pharmacokinetics of Voriconazole and Dose Optimization in Chinese Elderly Patients
Authors: Wang Jing , Shen Yue , Wu Zejun , zhu huaijun , Ge Weihong
Published: April 2023

Objectives: This study aimed to establish a population pharmacokinetic
model for elderly individuals receiving intravenous voriconazole, and to
assess and optimize the dosing regimens using a simulating approach.
Methods: A population pharmacokinetic analysis was conducted using the
NONMEN software based on 438 plasma concentrations from 150 elderly
patients receiving multiple intravenous doses of voriconazole. The
individualized optimal dosage regimen was proposed based on the obtained
population pharmacokinetics parameters. The final model was assessed by
the goodness of fit plots, non-parametric bootstrap method, and visual
predictive check. Monte Carlo simulations were carried out to assess and
optimize the dosing regimens with a therapeutic range of 2.0-5.0 mg/L as
the target plasma trough concentration (Cmin). Results: A
one-compartment model with first-order absorption and elimination fitted
well to the concentration-time profile of voriconazole. The typical
voriconazole clearance was 3.55 L/h, and the typical volume of
distribution was 194 L. Covariate analysis indicated that the CL of
voriconazole was substantially influenced by albumin (ALB), gamma
glutamyl transpeptidase, and direct bilirubin, while the volume was
associated with body weight. Conclusions: The first study on the
population pharmacokinetics of voriconazole in Chinese elderly people
was performed. Individualized dosing regimens were recommended for
different ALB levels based on population PK model prediction. The
proposed dosing regimens could provide a rationale for dosage
individualization to improve clinical outcomes and minimize drug-related
toxicities.
“The mask is not for you” : A framing analysis of pro- and anti-mask sentiment on Twitter
Authors: Mitchell Scott S.D. , Beanlands Josh
Published: April 2023

In the midst of the COVID-19 pandemic, widespread adoption of facemasks has been recognized as a low-cost, simple public health intervention that can reduce the transmission of the virus. However, early in the pandemic significant public opposition emerged in the U.S. and other parts of the world. So-called “anti-maskers” argue that COVID-19 is a hoax or the threat is overblown, that facemasks are ineffective, or that mask mandates infringe on personal rights and freedoms. Social media platforms can play an important role in shaping public sentiment about health issues, as well as circulating harmful misinformation. Researchers can also study social media data to better understand public perceptions and dominant discourses. This study examines four prominent mask-related hashtags on Twitter across three different time periods early in the pandemic. A content analysis of these tweets was used to investigate pro- and anti-mask wearing sentiment, the motivations behind these beliefs, the rhetorical strategies and themes present in these communications, and changes over time. Of the 600 tweets collected, 440 were pro-mask wearing, 134 were anti-mask wearing, and 26 did not declare a position. Pro-mask tweets used evidence at a rate of 28%, while anti-mask tweets used evidence at a rate of 16%. The most common motivation for a pro-mask position was mask-wearing as a civic duty, and the most common motivation for an anti-mask position was standing up to government tyranny. There were 68 tweets that expressed distrust in institutions, 97% of which were anti-mask, 44% mentioned a conspiracy theory while only 18% used evidence to support their position. It was found that mask sentiment on Twitter encompasses a variety of themes, worldviews, and rationales. Public health messaging must go beyond information transmission, and account for the complexity of the social, political, and economic factors which influence belief and behavior.
Who Will Help You to Practice Good Health Habits and Who Will Give You Eating Disorders? Analysis of WeightWatchers Twitter Network
Authors: Park SangHee , Joa Claire Youngnyo , Labbé Brett
Published: April 2023

This study explores the attributes and level of influence of Twitter users and how different types of network influencers emerge as agenda setters on WeightWatchers’ free diet program for teens. This study collected and analyzed data through the computer-assisted content analysis program and network analysis software, NodeXL. Celebrities on social networking sites were found to have greater centrality, but health advocates (against the Weight Watchers’ teens free program) also have the role of influencers. The WeightWatcher brand online community includes health advocates, researchers, activists, and non-profit organizations. While this study revealed that Twitter facilitated the emergence of a brand community sharing certain characteristics with public spheres, it also illustrates the degree to which the construction of public health frames by health advocates competes with celebrity influencers with greater levels of influence.
FAKE NEWS AND MISINFORMATION ON COVID-19: IMPLICATIONS FOR MEDIA CREDIBILITY IN NIGERIA
Authors: Okocha Desmond Onyemechi , Akpe Samuel Matthew
Published: April 2023

The start of the coronavirus disease in Nigeria in early 2020 created desperation for information. Everyone was eager to know something about the health issue, which killed people within days of infection. Questions requiring immediate answers ranged from what the symptoms were to what self-help remedy was appropriate. The media became a reliable platform to seek knowledge, and the coronavirus disease came at a time when social media proliferated. So, most people depended on this innovation for information on the disease. This was where falsehood, masquerading as news, tainted the minds of Nigerians. This paper, which uses framing theory as a theoretical framework, sought to examine how fake news and misinformation influenced the management of COVID-19 in Nigeria. It also set out to establish whether, in the perception and experiences of the population, the Nigerian media still command the trust of the people as reliable primary sources of news. The research purposively drew 30 interviewees and discussants from Nigeria’s six geo-political zones. The outcome showed that while some Nigerians were not personally affected by fake news or misinformation, they were quite aware of its negative impact on people they knew. This study recommends further investigation on why Nigerians still believe in the media despite infiltration and the influence of fake news. The general conclusion points toward the need to make media content more credible through professionalism and legal control.
Primary social emotions toward a non-player character: an examination of moral decision-making in video games
Authors: Dam Linda
Published: April 2023

This exploratory study examines the emotional responses toward non-player characters (NPCs) when challenged with an in-game moral decision (i.e. justified versus unjustified killing) and when exposed to game statistics on whether their moral choice aligned with the majority public. Using Buck et al.’s (2014) social and moral emotions (SAME) scale, participants (n = 301) completed an online experiment measuring their primary social emotions after being presented with a written scenario and screenshots from a popular video game that required participants to make a moral decision. Findings provide overall support for the interdependent connections in primary social emotions and revealed that embarrassment and shame were higher towards the NPC in the unjustified choice. Study results provide practical health implications for video game developers to develop and design more elaborate narrative paths that delve into the ethical tendencies of video game players.
The impact of communication anxiety regulation and fear of missing out on social media dependency: a study on transgender individuals in Turkey
Authors: Gorgulu Sahika
Published: April 2023

The current study aims to explore the impact of communication anxiety regulation and the fear of missing out on social media dependency, by specifically focusing on transgender individuals living in Turkey. Even though sexual orientation is not outlawed and legal sex change has been possible since 1988, Turkey stands as one of the most restrictive countries in Europe, when it comes to LGBT+ rights. In that sense, transgender individuals experience various social, political, and economic challenges throughout their lives, which have the potential to shape their relations with social media. Findings suggest that dimensions of communication anxiety regulation and fear of missing out determine social media dependency. Future studies should explore whether intense social media use as a result of communication anxiety and fear of missing out encourage productive activities such as interactive community support, self-help, and information seeking.
Mechanism of Action of Nerve Growth Factor Induced Histamine Release from Mast Cells during the Inflammation Process
Authors: Ferjan Ilonka
Published: April 2023

Mast cells and the biogenic amine, histamine, play a central role in inflammatory reactions. Nerve growth factor (NGF) is essetial for the survival of neurones and has significant role in inflammation and repair of tissues. It has been shown, that NGF induces degranulation of mast cells by interacting with tropomyosine-receptor kinase A (TrkA receptor). NGF can induce release of histamine and other mediators from mast cells or enhance secretion induced by different stimuli. The results of our and others previous studies show, that histamine release from mast cells induced by NGF is strongly dependent on the concentration of extracellular Na+ , Ca2+ ions. The extracellular Na+ ions can affect the activity of Na+ /Ca2+ exchanger of mast cells. Na+ , Ca2+ exchange mechanisms could be important in secretory process of mast cells. The studies of different signaling molecules in NGF induced histamine relese have shown that tyrosine kinase, phosphatidylinositol-3-kinase, protein kinase C and phospholipase C are also involved in the signal transduction process responsible for NGF induced histamine secretion from mast cells. These data indicate that NGF may contribute in allergic reactions and many other inflammatory states.
Ecigarette or Vaping Product Use Associated Lung Injury (EVALI) Reports to NPDS Implicated New Marijuana Substances
Authors: Spyker Dan
Published: April 2023

Context: Beginning Aug-2019, the Centers for Disease Control and Prevention (CDC) initiated investigation of e-cigarette or Vaping Product Use-Associated Lung Injury (EVALI). We examined all National Poison Data System (NPDS) EVALI cases through 31-Mar-2020 for substances, treatments, clinical effects, and medical outcome. We also examined all NPDS eCig exposures for earlier reports of EVALI. Methods: We extracted all exposures coded to EVALI product code 7322608 (E-Cigarette Associated Pulmonary Illness) and all single substance exposures to any of 6 NPDS eCig generic codes (GCs). We examined substance, patient characteristics, and exposure details on the severity of EVALI via multivariate analyses. We developed an EVALI clinical score (ECS) based on the EVALI clinical effects (CEs) and treatments weighted by the % of cases for each finding. We used ECS to search for EVALI candidate cases from 2001 to 31-Mar-2020. Descriptive statistics and change over time via linear and quadratic regression, and multivariate analyses were via (SAS JMP, 12.0.1). Discussion: Through 31-Mar-2020, PCs reported 822 EVALI cases. The EVALI profile over time 15-Aug - 12-Sep-2019 for 196 cases was described by an exponential increase with a doubling time [95% CI] of 8.31 [8.24, 8.37] days. Age: median [min, max] was 22 [1, 77] years, Male: 64.9%, Chronic 50.3%. Medical Outcomes included Death 1.95%, Major 17.9%, and Moderate 57.1%. Multivariate analysis of the first 107 EVALI cases as of 14-Sep-2019 implicated Marijuana Products (p=0.0007). Similar analyses of all 822 cases confirmed Marijuana (p<0.00001), Chronicity (p=0.00031), and Age (p=0.0152) contributing to CE score. Of the 23,252 eCig exposures (23,463 - 211 EVALI cases), 133 (0.567%) had an ECS > median and 370 (1.57%) scored > 25%tile of EVALI cases (EVALI-25+). The time course of these 370 eCig cases showed a distinct increase (inflection) ~16- Aug-2019. Conclusions: The first 107 NPDS EVALI case scores were related to marijuana product exposure. This was confirmed via similar analyses for all 822 cases. The numbers of EVALI-25+ cases show a distinct increase in Aug-2019, suggesting EVALI was a newly emerging phenomenon. Our analysis should encourage public health agencies to utilize NPDS, especially in data collection.
Ecological and Health Assessment of Heavy Metals Present in the Soil of E-Waste Collection, Recycling and Dismantling Sites in the Region of DAKAR, Senegal
Authors: Toure Aminata
Published: April 2023

Soil pollution from waste electrical and electronic equipment is a growing concern in Africa. The heavy metals contained in this waste are now one of the main sources of pollution and the handling of waste electrical and electronic equipment (WEEE) is increasingly a health and environmental concern. In Dakar, several handling points of this equipment were identified and our study investigated the presence of trace metals in the soil of e-waste handling sites in the Dakar region and about the spatial distribution of Pb, Cd, Cu, Cr, Fe, As, Hg and Mn according to the activity carried out on these sites. Three categories of activity were identified, namely collection, dismantling and recycling and a control site. The results show an abundance of metals for the collection and recycling sites which were such as Fe> Mn> Pb> Cu> Cr> Cd> As> Hg. In contrast, at the dismantling sites, the average total concentration of these elements was classified as Fe> Pb> Mn> Cu> Cr> As> Cd> Hg and that of the control site was Fe> Mn> Cu> Pb> Cr> Cd> As> Hg. The estimation of the potential ecological risk (Er) in relation to the control site shows an average risk coefficient for Fe, Mn and Cr below 40 for all sites, as well as for As in the collection and recycling sites and for Cu in the collection sites. Pb, Cd and Hg showed an average level of ecological “very high risk” for all sites and As also showed a “very high risk” for the dismantling sites for an ecological risk index of “Very high ecological risk” (RI> 600) for all sites associated with a non-carcinogenic risk greater than 1 for all site categories.
Opettajien monilukutaidolle antamat merkitykset
Authors: Hankala Mari , Kauppinen Merja , Kulju Pirjo
Published: April 2023

Tutkimuksen tavoitteena oli selvittää, miten opettajat ymmärtävät monilukutaidon käsitteen: millaisia merkityksiä he antavat monilukutaidolle ja millaisia orientaatioita heillä on sitä kohtaan. Monilukutaito on opetussuunnitelmassa laaja käsite, jonka haltuunotto ja soveltaminen vaativat kä sitteille annettavien merkitysten jäsentämistä ja niiden soveltamista oppimiseen. Tutkimusaineistona ovat täydennyskoulutukseen osallistuneiden 34 opettajan ennakkotehtävät. Niitä tarkasteltiin merkityksen rakentumisen fenomenologiasta käsin sekä diskurssianalyysin keinoin. Tulokset osoittavat, että opettajilla oli varsin laaja käsitys monilukutaidon multimodaalisesta luonteesta mutta käsitteen monikielinen ja -kulttuurinen sekä kriittinen näkökulma jäivät vähemmälle huomiolle. Opettajien orientaatiot monilukutaitoa kohtaan olivat muun muassa neutraaleja, kriittisiä ja epävarmoja. Opettajien yhteiset neuvottelut monilukutaidon käsitteestä ovat tarpeen, sillä yhteisen merkityspohjan päälle opettaja voi rakentaa omaa pedagogista repertuaariaan monilukutaidon opettamiseen. Tällaisille neuvotteluille on tärkeä tarjota mahdollisuuksia opettajankoulutuksessa ja täydennyskoulutuksessa.
 
Meanings given to multiliteracy by teachers
The aim of the study was to investigate how teachers understand the concept of multiliteracy: what kind of meanings they assign to multiliteracy, and what kind of orientations they have towards it. Multiliteracy is a broad concept in the curriculum, and wide understanding and appliance is needed to assimilate and apply it to teaching and learning. The research data consists of pre-assignments of 34 teachers who participated in the in-service training. The answers were considered from a phenomenological point of view as well as by means of discourse analysis. The results indicate that teachers had a quite broad understanding of the multimodal nature of multiliteracy, but the multilingual and cultural aspects of the concept were not considered widely enough. Teachers' orientations towards multiliteracy were, for example, neutral, critical, and uncertain. Teachers' joint discussions on the concept of multiliteracy are necessary. This way teachers can build their own pedagogical repertoire for teaching multiliteracy skills. It is important to provide opportunities for such discussions in teacher education and in-service training.
Keywords: teachers’ in-service training, multiliteracy, concept forming, curriculum
Marketing Mix Strategy Formulation in Bakery Store (Case Study: Pinnamon Bakery)
Authors: Kardinasari Natasya Fitri , Fachira Ira
Published: April 2023

The F&B industry is one of leading sector which successfully recorded a positive growth by 1.6% during pandemic even though Indonesia GDP is contracted by 2.1% YoY in 2020. One subsector of F&B industry is Bakery industry which has become the most competitive industry since the product intersects with human basic needs. The competition in bakery industry is very tough, each players compete to offer higher value with different strategy to get larger market share than the competitors. Pinnamon is one of the players in bakery industry in Pekanbaru that was established in 2019. Carrying unique product and different concepts, they try to steal bakery market through their signature product Cinnamon roll made from Danish pastry fill with marmalade pineapple, which is one of special fruit from Pekanbaru. In early of store opening, their product be in demand for several months. After that, Covid 19 pandemic and another several restrictions made the sales decrease. But, after covid recovered several times ago, the sales hard to bounce back as initial figure, and customer repetition very low only at 10%. Mixed method approach is used to get customer perceived value for Marketing mix in Pinnamon, through survey with 108 respondents and get deeper insight through deep in interview with 10 respondents. The results shows that Pinnamon has lack on their 7P marketing Mix, moreover on Place, Price, Physical Evidence and Product. Then the strategy is built to enhance value offered by Pinnamon in all aspect of Marketing Mix.
PENGARUH PENERAPAN MODEL “COOPERATIVE TIPE (STAD) BERBANTUAN POWERPOINT” TERHADAP HASIL BELAJAR IPA KELAS V SDN 06 KOTO BARU DHARMASRAYA
Authors: Saputra Andra
Published: April 2023

Penulisan penelitian ini dilatarbelakangi oleh (1) Interaksi antara siswa dengan siswa, dan siswa dengan guru dalam proses pembelajaran sangat minim sekali atau komunikasi di dalam kelas lebih sering terjadi komunikasi satu arah (2) siswa merasa takut dalam menyampaikan pendapat dan bertanya kepada guru kembali mengenai materi yang disampaikan, sehingga banyak siswa yang merasa jenuh ketika proses pembelajaran berlansung (3) pembelajaran merupakan sesuatu yang membosankan bagi siswa, tidak menarik dan membuat siswa tidak tertantang untuk belajar. Tujuan penelitian ini adalah (1) mengetahui apakah hasil belajar menggunakan model kooperatif stad berbantuan PowerPoint lebih tinggi secara signifikan (2) apakah hasil belajar menggunakan model kooperatif stad berbantuan PowerPoint sudah optimal (3) bagaimana pengaruh penerapan model kooperatif stad berbantuan PowerPoint terhadap hasil belajar siswa pada pelajaran IPA kelas V SDN 06 Koto Baru Dharmasraya.Populasi dalam penelitian ini berjumlah 40 orang. Sampel dilakukan dengan teknik total sampling teknik penentuan sampel bila semua anggota populasi digunakan sebagai Sample, yaitu Kelas V.A sebagai kelas eksperimen dan V.B sebagai kelas kontrol masing-masingnya berjumlah 20 orang. Teknik pengumpulan data adalah tes soal dalam bentuk objektif dan alat pengumpulan data adalah soal tes berbentuk objektif yang terdiri dari 40 butir soal.Hasil penelitian menemukan terdapat perbedaan yang signifikan dari hasil belajar siswa kelas eksperimen yang menggunakan model kooperatif stad berbantuan PowerPoint dan kelas kontrol menggunakan metode konvensional dengan rata rata kelas eksperimen (V.A) yaitu 84,25 dan nilai rata-rata kelas kontrol (V.B) yaitu 75.
PENGGUNAAN E-MODUL SEBAGAI BAHAN AJAR TERHADAP HASIL BELAJAR MAHASISWA PADA MATA KULIAH KONSEP DASAR IPA 2 DI STKIP ADZKIA PADANG
Authors: Wahyuni Sisri , Rifmasari Yessi , Antoni Adri
Published: April 2023

Buku ajar dalam dunia pendidikan merupakan suatu kebutuhan pokok baik bagi guru maupun mahasiswa sebagai pedoman dalam kegiatan pembelajaran sehingga dapat mencapai kompetensi yang diharapkan. Selain itu, beberapa sekolah tinggi juga menerapkan bahan ajar mandiri atau lebih dikenal dengan  modul. Tidak jauh berbeda dengan buku teks, modul juga dirancang secara sistematis dan juga berdasarkan kurikulum yang berlaku sehingga dapat mencapai kompetensi yang diharapkan. Modul lebih bersifat mandiri artinya dengan adanya modul siswa mahasiswa dapat belajar tanpa harus tatap muka dengan dosen. Mahasiswa dapat belajar sendiri atau berkelompok yang berpedoman kepada modul tersebut sehingga ketuntasan belajar mahasiswa dapat dilihat dari ketercapaiannya dalam mempelajari materi yang ada di modul. Sedangkan buku teks lebih umum, hanya saja peran dosen sangat lebih mendominasi dibandingkan dengan peran dosen  yang menerapkan bahan ajar modul sebagai sumber belajar dalam kegiatan belajarnya. Jenis penelitian ini yaitu penelitian kuantitatif, desain penelitian Quasi Eksperimental dengan rancangan penelitian Nonequivalent Control Group Design. Populasi dan juga sampel dalam penelitian ini adalah seluruh mahasiswa semester 2 STKIP Adzkia terdiri atas 2 kelas. Kelas IIA sebagai kelas eksperimen yang menggunakan e-modul dan IIB menggunakan metode konvensional sebagai kelas kontrol. Data yang diperoleh dianalisis dengan menggunakan uji-t. Hasil penelitian ini, diperoleh rata-rata hasil belajar  kelas eksperimen= 81,4 dan di kelas kontrol= 66,16, yang mana  kelas eksperimen lebih besar dari kelas kontrol. Berdasarkan analisis uji-t di peroleh   6,1 dan  = 1,665 pada taraf nyata 0,05 dengan thitung lebih besar dari pada ttabel. Hasil penelitian ini terbukti bahwa penggunaan e-modul memberikan pengaruh terhadap hasil belajar siswa pada perkuliahan konsep dasar 2 di STKIP Adzkia Padang. Kata Kunci :  E- modul, Hasil Belajar
PERSONAL DEIXIS USED IN MALCOLM X’S “THE BALLOT OR THE BULLET” SPEECH
Authors: Gobel Fakhirah , Lihawa Kartin , Hasanuddin Hasanuddin
Published: April 2023

This study aims to observe and describe the types of personal deixis used in Malcolm X’s “The Ballot or The Bullet” speech using the theory of Yule (1996). In collecting the data, this qualitative descriptive method was used by watching the video documentation, downloading the transcript, and reading the script that contain personal deixis in the speech. The theory of Miles and Huberman (1994) was used in this study as the steps to analyze the data which consists of data reduction, data display, and data drawing. The result of this study found out there was 662 deixis that consisted of three types of person deixis which are first-person, second-person, and third-person divided into 14 types of personal deixis use, i.e 222 first-person deixes, 211 second-person deixis, and 229 third-person with second-person deixis You (174 times use), They (84 times use) and We (79 times use) as the most often used type in the speech. In addition, Malcolm X used personal deictic expressions as a way to motivate and influence the African-American community in empowering the important philosophy of black nationalism against the racism issue of the African-American community in the  20th-century era.
BOOK REVIEW: MULTIMODALITY IN ENGLISH LANGUAGE LEARNING
Authors: Sugianto Ahmad
Published: April 2023

Multimodality has been one of the prominent and burgeoning fields and phenomena in English classrooms. It is based on both the credence which is proven by scholarly evidence that English language learning and instruction will be significantly and effectively delivered if more than one semiotic resource or mode is used. Lots of scholars across the globe have taken part in portraying such significance and effectiveness of multimodality concerning English classrooms.  Diamantopoulou and Ørevik (2022) have conflated sheer studies from various distinguished authors providing ‘fresh’ outlooks of the use of multimodality, particularly in English as an additional language (EAL) context across the globe. The use of multimodality in EAL is concisely discussed from various lenses, from its salient perspectives, and pedagogical practices through assessments. Thus, this book is recommended to those who are concerned and willing to capture the latest trajectories of the use of multimodality pertaining to EAL by its par excellence as well as the matter at hand.
THE PROBLEM OF TEACHING ENGLISH IN ELEMENTARY SCHOOL-BASED ON TEACHER INVOLVED: EXPLORING TEACHER'S PERSPECTIVE
Authors: Noor Zulfikar , Harahap Addinul Kamil , Dewi Utami
Published: April 2023

English-teaching problem is an important issue that has been discussing and in diverse contexts around the world, including English teacher problems, students, assessments, curricula and textbooks, and the various variables that contribute to effective English as a foreign language (EFL) teaching, for this reason, the purpose of the study is to explore 10 participants’ perspective in issues of teaching English in ELT classroom. This descriptive qualitative study investigated how teachers perceived the English teaching issue based on the teachers involved. Data were collected using a questionnaire that includes a single primary question about the use of Teaching-English issues that were raised by teachers. This study came to three main conclusions: (1) Teachers' emotional control. (2) Personal experience of teachers. (3) The teacher's interest in the character of the pupil. (4) Teaching staff accountability. Finally, Problems with teaching English should not be understated because they have a significant impact on how well students learn the language in elementary schools. To continuously improve their teaching skills without becoming complacent, teachers must be aware of their shortcomings.
Achieving Professional and Personal Goals At the Beginning of the Year 2023
Authors: Fong Neale
Published: April 2023

Welcome to the first issue of the College’s Asia Pacific Journal of Health Management for 2023. I trust the year is treating you well and you are well on your way to achieving professional and personal goals set at the beginning of the year.
The College is moving forward with a successful year, too. In March we held a hugely successful Health Leadership Conference in Melbourne with well over 200 attendees. The focus on the common issues of leadership, workforce concerns and health system sustainability as well as aged care leadership and management was appreciated by all who participated. These issues of Workforce and Sustainability will be explored in more detail at the ACHSM Asia-Pacific Health Leadership Congress to be held in Canberra, 11-13 October, 2023. Please put a hold on those dates in your diary and register for this Congress.....