bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S3 from MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
Authors: Engstrom Lars D. , Aranda Ruth , Waters Laura , Moya Krystal , Bowcut Vickie , Vegar Laura , Trinh David , Hebbert Allan , Smith Christopher R. , Kulyk Svitlana , Lawson J. David , He Leo , Hover Laura D. , Fernandez-Banet Julio , Hallin Jill , Vanderpool Darin , Briere David M. , Blaj Alice , Marx Matthew A. , Rodon Jordi , Offin Michael , Arbour Kathryn C. , Johnson Melissa L. , Kwiatkowski David J. , Jänne Pasi A. , Haddox Candace L. , Papadopoulos Kyriakos P. , Henry Jason T. , Leventakos Konstantinos , Christensen James G. , Shazer Ronald , Olson Peter
Published: November 2023

5-Day in vitro viability data
Supplementary Figure S3 from MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
Authors: Engstrom Lars D. , Aranda Ruth , Waters Laura , Moya Krystal , Bowcut Vickie , Vegar Laura , Trinh David , Hebbert Allan , Smith Christopher R. , Kulyk Svitlana , Lawson J. David , He Leo , Hover Laura D. , Fernandez-Banet Julio , Hallin Jill , Vanderpool Darin , Briere David M. , Blaj Alice , Marx Matthew A. , Rodon Jordi , Offin Michael , Arbour Kathryn C. , Johnson Melissa L. , Kwiatkowski David J. , Jänne Pasi A. , Haddox Candace L. , Papadopoulos Kyriakos P. , Henry Jason T. , Leventakos Konstantinos , Christensen James G. , Shazer Ronald , Olson Peter
Published: November 2023

Thermal shift PRMT5 inhibitor data
Supplementary Figure S8 from BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance
Authors: Zhao Liwei , Liu Peng , Mao Misha , Zhang Shuai , Bigenwald Camille , Dutertre Charles-Antoine , Lehmann Christian H.K. , Pan Hui , Paulhan Nicolas , Amon Lukas , Buqué Aitziber , Yamazaki Takahiro , Galluzzi Lorenzo , Kloeckner Benoit , Silvin Aymeric , Pan Yuhong , Chen Hui , Tian Ai-Ling , Ly Pierre , Dudziak Diana , Zitvogel Laurence , Kepp Oliver , Kroemer Guido
Published: November 2023

Supplementary Figure S8 shows T cell-priming by adoptively transferred cDC1 cells, their T-cell dependent cancer-regressing effect, as well as sensitization to PD-1 blockade.
Supplementary Figure S5 from BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance
Authors: Zhao Liwei , Liu Peng , Mao Misha , Zhang Shuai , Bigenwald Camille , Dutertre Charles-Antoine , Lehmann Christian H.K. , Pan Hui , Paulhan Nicolas , Amon Lukas , Buqué Aitziber , Yamazaki Takahiro , Galluzzi Lorenzo , Kloeckner Benoit , Silvin Aymeric , Pan Yuhong , Chen Hui , Tian Ai-Ling , Ly Pierre , Dudziak Diana , Zitvogel Laurence , Kepp Oliver , Kroemer Guido
Published: November 2023

Supplementary Figure S5 contains evidence indicating that BCL2 inhibitors synergize with immune checkpoint blockades in different mouse orthotopic cancer models.
Early Clinical Success of MTA-Cooperative PRMT5 Inhibitors for the Treatment of CDKN2A/MTAP-Deleted Cancers
Authors: Mulvaney Kathleen M.
Published: November 2023

CDKN2A encodes the tumor suppressors p16 and p14ARF and is the most common homozygously deleted gene in all human cancers; tumors frequently codelete the nearby gene MTAP, creating a dependency on PRMT5. In this issue of Cancer Discovery, Engstrom and colleagues report an MTA-cooperative PRMT5 methyltransferase inhibitor MRTX1719 that selectively kills CDKN2A/MTAP-codeleted cancers and demonstrates early efficacy in clinical trials for solid tumors harboring the CDKN2A/MTAP codeletion.

See related article by Engstrom et al., p. 2412 (1).
Supplementary Table 1 from Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer
Authors: Adewunmi Oluwatoyosi , Shen Yichao , Zhang Xiang H.-F. , Rosen Jeffrey M.
Published: November 2023

Supplementary Table 1
Supplementary Figure 6 from Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer
Authors: Adewunmi Oluwatoyosi , Shen Yichao , Zhang Xiang H.-F. , Rosen Jeffrey M.
Published: November 2023

Supplementary Figure 6
Supplementary Figure 3 from Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function
Authors: Zhang Caimei , Kadu Siddhant , Xiao Yansen , Johnson Omar , Kelly Andre , O'Connor Roddy S. , Lai Meizan , Kong Hong , Srivatsa Sriram , Tai Victoria , Greenblatt Eli , Holmes Matthew , Riley James L. , June Carl H. , Sheppard Neil C.
Published: November 2023

Figure S3. Expressions of activating receptors and cell death ligands on freshly isolated-NK cells and
2 expanded-NK cells.
Supplementary Figure 2 from Sequential Exposure to IL21 and IL15 During Human Natural Killer Cell Expansion Optimizes Yield and Function
Authors: Zhang Caimei , Kadu Siddhant , Xiao Yansen , Johnson Omar , Kelly Andre , O'Connor Roddy S. , Lai Meizan , Kong Hong , Srivatsa Sriram , Tai Victoria , Greenblatt Eli , Holmes Matthew , Riley James L. , June Carl H. , Sheppard Neil C.
Published: November 2023

Figure S2. Representative flow plots of SSA against FSA and the expression of CD56 and CD3 of NK
2 cells as well as the gating strategy for counting NK cells
Supplementary Video 3 (DARA) from slan+ Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Authors: Finotti Giulia , Pietronigro Enrica , Balanzin Camillo , Lonardi Silvia , Constantin Gabriela , Chao Mark P. , Tecchio Cristina , Vermi William , Cassatella Marco A.
Published: November 2023

Supplementary Video 3
Supplementary Video 2 (5F9) from slan+ Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by Trogoptosis
Authors: Finotti Giulia , Pietronigro Enrica , Balanzin Camillo , Lonardi Silvia , Constantin Gabriela , Chao Mark P. , Tecchio Cristina , Vermi William , Cassatella Marco A.
Published: November 2023

Supplementary Video 2
Table S8 from Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy
Authors: Eide Christopher A. , Kurtz Stephen E. , Kaempf Andy , Long Nicola , Joshi Sunil Kumar , Nechiporuk Tamilla , Huang Ariane , Dibb Charles A. , Taylor Akosha , Bottomly Daniel , McWeeney Shannon K. , Minnier Jessica , Lachowiez Curtis A. , Saultz Jennifer N. , Swords Ronan T. , Agarwal Anupriya , Chang Bill H. , Druker Brian J. , Tyner Jeffrey W.
Published: November 2023

Validation target sgRNA and TIDE primer reagent sequences
Table S7 from Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy
Authors: Eide Christopher A. , Kurtz Stephen E. , Kaempf Andy , Long Nicola , Joshi Sunil Kumar , Nechiporuk Tamilla , Huang Ariane , Dibb Charles A. , Taylor Akosha , Bottomly Daniel , McWeeney Shannon K. , Minnier Jessica , Lachowiez Curtis A. , Saultz Jennifer N. , Swords Ronan T. , Agarwal Anupriya , Chang Bill H. , Druker Brian J. , Tyner Jeffrey W.
Published: November 2023

Cell line DE genes for VEN+Ruxolitinib
Association of Dietary Polyunsaturated Fatty Acid Intake with Allergic Rhinitis in Adults: A Cross-Sectional Study of NHANES 2005–2006
Authors: Jiao Wo-Er , Xi Yang , Li Di , Xu Shan , Kong Yong-Gang , Deng Yu-Qin , Yang Rui , Tao Ze-Zhang , Hua Qing-Quan , Chen Shi-Ming
Published: November 2023

Introduction: The incidence of allergic rhinitis (AR) is increasing year by year, and the pathogenesis is complex, in which diet may play an important role. The role of polyunsaturated fatty acids (PUFAs) in AR is still controversial. Previous studies have looked at the effects of PUFA during pregnancy, childhood, and adolescence. In this study, we aimed to determine the association between dietary intake of PUFA and AR in adults. Methods: We used the NHANES database from 2005 to 2006 to include a total of 4,211 adult subjects. We collected dietary PUFA intake data and information on AR. Logistic regression and restricted cubic spline models were constructed to examine the association between PUFA intake and AR in adults. The t test was used to compare daily PUFA intakes in patients with and without AR. Results: In the fully adjusted model (OR: 1.016; 95% CI: 1.003; 1.028), PUFA intake was positively correlated with allergic symptoms, hay fever, and AR in adults (p < 0.05). In addition, daily PUFA intake was significantly higher in people with allergic symptoms, hay fever, and AR than in people without the disease (p < 0.01). Conclusions: Our results suggest a positive association between dietary PUFA intake and AR in adults to a certain extent. Future studies on dietary PUFA dose will provide new strategies for the prevention and treatment of allergic diseases such as AR related to non-pharmaceutical interventions.
Prolonged Complete Response with Lenalidomide in a Relapsed Diffuse Large B-Cell Lymphoma, Leg-Type: A Case Report
Authors: Zoli Sabrina , Pellegrini Cinzia , Casadei Beatrice , Broccoli Alessandro , Argnani Lisa , Nanni Laura , Stefoni Vittorio , Zinzani Pier Luigi
Published: November 2023

Introduction: For primary cutaneous diffuse large B-cell lymphoma, leg-type (PCDLBCL-LT), there are no uniform recommendations for second-line treatment in case of relapse. Case Presentation: Here, we present the case of an elderly relapsed/refractory PCDLBCL-LT patient who obtained a prolonged clinical complete remission with lenalidomide. Conclusion: Lenalidomide as single agent led to an unexpected long complete response with manageable toxicity.
Exu e a História do Tempo Presente: uma encruzilhada possível?
Authors: Mira Vinícius José
Published: November 2023

Esse texto tem como objetivo estabelecer um diálogo entre Exu, orixá mensageiro das religiões afro-brasileiras, e a História do Tempo Presente, uma nova atitude metodológica no fazer historiográfico datada de meados da segunda metade do século XX, oriunda da França. Para tal, é feito uso de bibliografia atinente produzida por intelectuais de terreiro, tais como Luiz Rufino, Pai Rodnei de Oxóssi, Muniz Sodré e Ronilda Iyakemi Ribeiro, em diálogo com pensadores relevantes aos debates da Teoria da História, nomeadamente, Walter Benjamin, Chimamanda Ngozie Adichie, José D’Assunção Barros e Reinhart Koselleck. O texto está dividido em três partes. Na primeira delas, as possibilidades teórico-metodológicas da Exunêutica para a operação historiográfica são discutidas, almejando transformar a cruz cristã – sob(re) a qual a disciplina histórica foi erigida – na encruzilhada de Exu. Na sequência, Walter Benjamin e Chimamanda Ngozie Adichie encontram Exu e os combates contra os perigos de uma história única ganham um poderoso aliado. Na terceira e última parte, concluo o texto tecendo reflexões gerais sobre as diversas discussões apresentadas.
Na saúde e na doença: a legalidade nas sanções à recusa de imunização contra a covid-19
Authors: Meirelles Jussara Maria Leal de , Schulman Gabriel
Published: November 2023

Em 11 de março de 2020, o diretor geral da Organização Mundial da Saúde classificou o estado da disseminação de covid-19 como uma pandemia mundial. O rápido desenvolvimento de vacinas permitiu a imunização da população e, por outro lado, fez surgirem debates acerca da possibilidade de recusa à vacinação ou, ainda, de imposição do dever de se vacinar. Sob tal contexto, por meio de revisão bibliográfica o presente artigo examinou a decisão do Supremo Tribunal Federal que reconheceu a inconstitucionalidade da vacinação à força e, por outro lado, a constitucionalidade da imposição de sanções em face da recusa de se imunizar. A pesquisa identificou os principais fundamentos do acórdão e problematizou a hipótese de imposição de sanções em caso de recusa de se imunizar.
Detailed Assessment of the “I Need Help” Criteria in Patients With Heart Failure: Insights From the HELP-HF Registry
Authors: Pagnesi Matteo , Ghiraldin Daniele , Vizzardi Enrico , Chiarito Mauro , Stolfo Davide , Baldetti Luca , Adamo Marianna , Lombardi Carlo Mario , Inciardi Riccardo Maria , Tomasoni Daniela , Loiacono Ferdinando , Maccallini Marta , Villaschi Alessandro , Gasparini Gaia , Montella Marco , Contessi Stefano , Cocianni Daniele , Perotto Maria , Barone Giuseppe , Sartori Samantha , Davison Beth A. , Merlo Marco , Cappelletti Alberto Maria , Sinagra Gianfranco , Pini Daniela , Metra Marco
Published: November 2023

BACKGROUND:

The “I Need Help” markers have been proposed to identify patients with advanced heart failure (HF). We evaluated the prognostic impact of these markers on clinical outcomes in a real-world, contemporary, multicenter HF population.

METHODS:

We included consecutive patients with HF and at least 1 high-risk “I Need Help” marker from 4 centers. The impact of the cumulative number of “I Need Help” criteria and that of each individual “I Need Help” criterion was evaluated. The primary end point was the composite of all-cause mortality or first HF hospitalization.

RESULTS:

Among 1149 patients enrolled, the majority had 2 (30.9%) or 3 (22.6%) “I Need Help” criteria. A higher cumulative number of “I Need Help” criteria was independently associated with a higher risk of the primary end point (adjusted hazard ratio for each criterion increase, 1.19 [95% CI, 1.11–1.27];
P
<0.001), and patients with >5 criteria had the worst prognosis. Need of inotropes, persistently high New York Heart Association classes III and IV or natriuretic peptides, end-organ dysfunction, >1 HF hospitalization in the last year, persisting fluid overload or escalating diuretics, and low blood pressure were the individual criteria independently associated with a higher risk of the primary end point.

CONCLUSIONS:

In our HF population, a higher number of “I Need Help” criteria was associated with a worse prognosis. The individual criteria with an independent impact on mortality or HF hospitalization were need of inotropes, New York Heart Association class or natriuretic peptides, end-organ dysfunction, multiple HF hospitalizations, persisting edema or escalating diuretics, and low blood pressure.
Variation in the diets of western mosquitofish (Gambusia affinis) in two ponds: effects of time and coexistence with centrarchid fishes
Authors: Rettig Jessica E. , Surace Margaret , Rose Kyle D. , Baird Andrew J. , Baker Zachary D. , Smith Geoffrey R.
Published: November 2023

Western mosquitofish, Gambusia affinis, have been introduced around the world, and can affect native fish through competition and predation. The diet of G. affinis may therefore determine the extent of their interactions with native species. We examined stomach contents of G. affinis from two ponds in central Ohio in 2010, 2015, and 2016. In Olde Minnow Pond, we collected diet data before and after the introduction of the native sunfish, Lepomis megalotis, in 2014. We also collected data for G. affinis for the same period in Wood Duck Pond that has contained G. affinis and Lepomis macrochirus for years prior to the study period. The most important prey were zooplankton, especially Chydorus sp. and Alona sp. Aquatic insects, especially chironomid larvae, were often found in stomachs, with their importance varying by year. The relative consumption of zooplankton increased dramatically in G. affinis , especially females, in Olde Minnow Pond from 2010 to 2015 but then dropped in 2016. In addition, the relative consumption of aquatic insects increased in Olde Minnow Pond after the arrival of L. megalotis compared to 2010. In contrast, the diets of G. affinis in Wood Duck Pond remained relatively similar across the study period. Male and female G. affinis in Olde Minnow Pond had different diets, whereas the diets of males and females in Wood Duck Pond were generally similar. In conclusion, the results of this natural experiment provide circumstantial evidence that the arrival of L. megalotis in Olde Minnow Pond affected the diet of G. affinis.
A biotechnological method for silkworm sex regulation
Authors: Shukurlu Yusif , Sharifova Madina
Published: November 2023

The aim of this work is to use the biotechnological method of silkworm sex regulation as a breeding method. For this purpose, butterflies were mated immediately after their emergence in a chamber with a constant magnetic field for 4 h. By studying the natural fertilization of the Sheki-2 silkworm in a constant magnetic field, it was possible to change the natural sex ratio of the offspring from 1:1 to 1:3 in favour of males. A direct positive correlation was observed between the magnetic field strength and an increase in the number of males in the offspring, with the maximum number of males observed at a strength of 729.7 kA/m. The developed mathematical model made it possible to calculate the activation coefficient of magnetic fields influencing the cytogenetic process in the silkworm, which was 4.02 × 10−3 kA/m. An attempt was also made to explain the mechanism behind the cytogenetic influence of a constant magnetic field on possible options for obtaining males during the natural fertilization of silkworm females. Implementation of the developed method in the breeding programme will enhance both the quantity and quality of silkworm productivity. This is achieved by increasing silk yield and improvement of the raw materials obtained from the males. If these positive outcomes are consistently observed in other silkworm breeds, this method has the potential to become widely adopted for large-scale breeding of the entire silkworm population in the country.
Three new free-living marine nematode species of Subsphaerolaimus Lorenzen, 1978, Halichoanolaimus de Man, 1886 and Belbolla Andrássy, 1973 from mangrove wetlands in Taiwan
Authors: XIAO YUEPING , GUO YUQING
Published: November 2023

Three new species of free-living marine nematodes belonging to the genera Subsphaerolaimus, Halichoanolaimus and Belbolla are described from the mangrove wetlands of western Taiwan Island. Subsphaerolaimus danshuiensis sp. nov. is characterized by a body length of 1345–1693 µm, subcephalic setae 22.5–65.0 µm long, cervical setae 16.5–33.0 µm long, an “L”-shaped spicule 66.9–76.4 μm long, and a gubernaculum with a caudally-dorsally directed apophysis 16.4–23.0 µm long. Halichoanolaimus sicaoensis sp. nov. is characterized by an amphidial fovea with 3.5–3.75 turns, a conico-cylindrical tail with the cylindrical portion approximately 3/4 of the total tail length, and 13–14 not equidistant papillose precloacal supplements. Belbolla forkyspicula sp. nov. is characterized by seven oesophageal bulbs, a short tail, a spicule with a proximal fork, and two winged supplements. Differentiating characteristics of the genera Subsphaerolaimus, Halichoanolaimus and Belbolla are provided. Types are deposited in the College of Fisheries, Jimei University.
The Diverse Impacts of El Niño on Northeastern Canada and Greenland Surface Air Temperatures
Authors: Gan Ruyu , Huang Gang , Hu Kaiming
Published: November 2023

El Niño is known to affect Arctic temperature. However, the robustness of the observed relationship between El Niño and Arctic temperature remains debated. Here we reexamine the impacts of El Niño on the Arctic temperature in boreal winter [December–February (DJF)] using reanalysis datasets and atmospheric model experiments. This study shows that extreme El Niño events are accompanied by significant boreal winter cooling over northeastern Canada and Greenland (NECG), while moderate eastern Pacific (MEP) El Niño events are accompanied by significant boreal winter warming in this region. For central Pacific (CP) El Niño events, a cold signal appears in NECG, but with no statistical significance. During extreme El Niño winters, a positive Pacific–North America (PNA)-like pattern is seen in the Pacific, and anomalously negative 200-hPa geopotential height (Z200) strengthening occurs over NECG, which is a response to anomalous strong wave activity originating in the tropical Pacific. El Niño–induced circulation anomalies can further induce NECG cooling via cold temperature advection and decreased downward longwave radiation. In contrast, for the MEP El Niño, the subtropical jet extends zonally from the North Pacific to the North Atlantic, which is accompanied by increased baroclinicity anomalies and favors the propagation of synoptic eddies into the Atlantic, leading to a negative North Atlantic Oscillation (NAO)-like pattern. This in turn could further enhance the positive Z200 anomalies over NECG, resulting in anomalous warming in NECG through warm temperature advection and enhanced downward longwave radiation. A series of atmospheric model experiments simulates the observed circulation changes and associated warming over NECG.

Significance Statement

This work investigates the different impacts of the three El Niño types on regional Arctic wintertime temperature anomalies based on observations and model experiments. The impacts of El Niño events on northeastern Canada and Greenland temperatures during boreal winter show distinct differences between extreme El Niño and moderate EP El Niño events. These distinct differences can be attributed to the different atmospheric circulation patterns induced by different SST patterns, which can lead to warm (cold) temperature advection and enhanced (decreased) downward longwave radiation. These results highlight the different impacts of extreme and moderate EP El Niños on Arctic temperatures and provide an improved understanding of the impact of El Niños on the Arctic climate.
On the Risk Efficiency of a Weather Index Insurance Product for the Brazilian Semiarid Region
Authors: Lavorato Mateus P. , Braga Marcelo J.
Published: November 2023

Weather index insurance (WII) has long been advertised as a viable alternative to crop yield insurance. WII products were first developed to assist climate-vulnerable farmers from developing countries where establishing a well-structured crop insurance market is expressively difficult due to the poor transport infrastructure and the prevalence of sparsely distributed small-scale farms. In Brazil, the semiarid region stands out as the one that concentrates the ideal conditions for the implementation of a WII product since it houses thousands of climate-vulnerable farmers. With this in mind, we designed and priced a WII product for farmers from the semiarid region of Brazil and posteriorly investigated its risk efficiency. To do so, we first investigated crop yield responses to aridity, enabling the selection of locations for which the WII product was posteriorly assessed. Second, we grouped selected locations into specific contracts according to geographical proximity and evaluated each of these contracts to attest the risk efficiency of the proposed WII product using the method of stochastic efficiency with respect to a function (SERF), which identifies utility efficient alternatives for a range of risk attitudes. Our results show that the WII product may be effective in protecting farmers from adverse variations in production revenue, possibly being attractive for utility-maximizer farmers that are sufficiently risk averse.
Evaluation of Critical Care Pharmacist Evening Services at an Academic Medical Center
Authors: Chase Aaron M. , Forehand Christy C. , Keats Kelli R. , Taylor Ashley N. , Jones Timothy W. , Sikora Andrea
Published: November 2023

Purpose: Critical care pharmacists are considered essential members of the healthcare team; however, justification and recruitment of new positions, especially in the evening or weekend shifts, remains a significant challenge. The purpose of this study was to investigate the number of interventions, type of interventions, and associated cost savings with the addition of 1 board certified critical care clinical pharmacist to evening shift. Methods: This was a prospective collection and characterization of 1 evening shift critical care pharmacist’s clinical interventions over a 12-week period. Interventions were collected and categorized daily from 13:00 to 22:00 Monday through Friday. After collection was complete, cost savings estimates were calculated using pharmacy wholesaler acquisition cost. Results: Interventions were collected on 52 of 60 weekdays. A total of 510 interventions were collected with an average of 9.8 interventions accepted per day. The most common interventions included transitions of care, medication dose adjustment, and antibiotic de-escalation and the highest proportion of interventions occurred in the medical intensive care unit. An estimated associated cost avoidance of $66 537.80 was calculated for an average of $1279.57 saved per day. Additionally, 22 (4.1%) of interventions were considered high yield interventions upon independent review by 2 pharmacists. Conclusion: The addition of 1 board-certified critical care pharmacist to evening shift resulted in multiple interventions across several categories and a significant cost avoidance when calculated using conservative measures.
Regulating fabricated information on social media: A scoping review
Authors: Fidelis Antidius , Mwantimwa Kelefa , Mwiburi Abel
Published: November 2023

The dissemination of fabricated information is not a new phenomenon in human society. However, recent developments in social media have massively increased the creation and dissemination of this information. This study employed a scoping review method to ascertain fabricated information contexts, regulatory frameworks, and impediments in regulating the information. Google and Google Scholar search engines were used to identify documents published between 2006 and 2022 on fabricated information and regulatory frameworks. The data in these studies were subjected to thematic analysis. The study reveals that Facebook and Twitter produce a large quantity of fabricated information and that most of the information is created and disseminated from political and health contexts. Besides, the study shows that despite the available regulatory frameworks for curbing fabricated information, the problem persists. This has been attributed to diverse challenges associated with the regulation of information. A universal mechanism and regulatory framework should be enacted to regulate fabricated information effectively.
Determining mechanical and acoustical behaviors of all-recycled PP sandwich structures with bi-directional sinusoidal corrugated core
Authors: Türkoğlu İbrahim Kürşad , Yazıcı Murat
Published: November 2023

By recycling the waste polymer material and using it in weight reduction studies of electric vehicles, a double-sided gain is achieved against environmental pollution. Sandwich structures with prismatic cores obtained by recycling waste polymers can be used in structural applications of light and heavy commercial vehicles and public transportation vehicles that carry cargo and passengers. These sandwich vehicle parts could help to increase the max. range and load-carrying capacity of electric vehicles. In this study, sandwich plates with prismatic egg-box cores were produced with waste Polypropylene. Since the materials are collected from different waste sources, the physical properties (additive ratio, secondary substance determination, density) of the recycled material were measured. Thereafter, hardness, quasi-static flatwise and edgewise compression, and 3-point bending tests were done to determine the mechanical properties of the structure. After that, dynamic compression and 3-point bending tests were performed to determine the strength and impact energy absorption capacity of the structure in collision situations. Finally, impedance tube tests were carried out for the acoustic characterization, which is one of the important parameters affecting interior cabin comfort, and Sound Transmission Loss (STL) and Sound Absorption Coefficient (SAC) values of the structure were determined.
An investigation of P-12 school administrator stress in South Dakota
Authors: Schutter Nicole , Puglisi Christopher , Meyerink Monte
Published: November 2023

Stress is a demand made between the adaptive ability of the mind and body and the experience and resources available to cope with those demands and has become an epidemic in society and notably in educational settings. With the growing emphasis of overall wellbeing of students, few studies have focused on those who are in charge of the wellbeing of those students: school administrators. This study aimed to identify factors that impact stress in P-12 (Preschool-Grade 12) school administrators in South Dakota by administering the Administrative Survey Index (ASI). A total of N = 253 school administrators completed the survey. Initial results indicate that administrative constraints, interpersonal relations, and intrapersonal conflicts were the greatest sources of stress. Additionally, the degree to which an ASI item was a source of stress varied by administrators’ gender, occupational title, and grade range of students. The findings are discussed and future directions for research are presented.
Measuring Hate: Does a Definition Affect Self-Reported Levels of Perpetration and Exposure to Online Hate in Surveys?
Authors: Hawdon James , Reichelmann Ashley , Costello Matthew , Llorent Vicente J. , Räsänen Pekka , Zych Izabela , Oksanen Atte , Blaya Catherine
Published: November 2023

The purpose of this research is to test the validity of commonly used measures of exposure to and production of online extremism. Specifically, we investigate if a definition of hate influences survey responses about the production of and exposure to online hate. To explore the effects of a definition, we used a split experimental design on a sample of 18 to 25-year-old Americans where half of the respondents were exposed to the European Union’s definition of hate speech and the other half were not. Then, all respondents completed a survey with commonly used items measuring exposure to and perpetration of online hate. The results reveal that providing a definition affects self-reported levels of exposure and perpetration, but the effects are dependent on race. The findings provide evidence that survey responses about online hate may be conditioned by social desirability and framing biases. The findings that group differences exist in how questions about hate are interpreted when definitions of it are not provided mean we must be careful when using measures that try to capture exposure to and the production of hate. While more research is needed, we recommend providing a clear, unambiguous definition when using surveys to measure online hate.
Public preferences for social investment versus compensation policies in Social Europe
Authors: Eick Gianna M , Burgoon Brian , Busemeyer Marius R
Published: November 2023

The recent enactment of the European Pillar of Social Rights (EPSR) has significantly strengthened the social dimension of the European Union (EU), including the social investment (SI) elements of that social dimension. What is not known, however, to what extent the priorization of SI is supported by the broader public. To address this research gap, we investigate public opinion on 15 different policy areas from the EPSR using Eurobarometer data from 2020 across all EU countries, asking whether the public rather prefers these policies to be delivered at EU or national level. A principal finding is that the public indeed supports more SI than CP policies with respect to EU-level social policy, and more CP than SI policies with respect to national-level social policy. We also investigate whether socioeconomic status (SES) and welfare state effort can explain this phenomenon. We find that higher socio-economic status and more generous welfare states are associated with more support for SI policies on both EU and national levels and vice versa. The findings emphasize the importance of what policies are provided versus who provides them but also pose a puzzle for trade-offs in multilevel governance settings. Hence, the article has important implications for future research on public opinion and Social Europe.
Riding the tides: Directions in mental health rehabilitation in NSW
Authors: McDonald Andrew , Still Megan , Sommer Joanne , Coniglio Francesca
Published: November 2023

Objective

This paper outlines the evolution of mental health rehabilitation in NSW, where allocation of health resources has repeatedly contradicted the policy intention to reorient services from inpatient to community-based services, leaving community rehabilitation the poor and disconnected cousin of inpatient services. The expanding role of community-managed organisations (CMOs) in psychosocial rehabilitation, the introduction of the National Disability Insurance Scheme (NDIS), and emerging service models have helped foster a maturing housing and social care environment, but present reality and the integration of health and social care services remains at a distance from best evidence practice.

Conclusion

The challenge of the next decade of mental health reform is to embrace and consolidate greater service diversity and complexity. Understanding what factors influenced present reality is important in providing guardrails for the future, enabling the current wave of renewal and reinvestment in NSW to build on the strengths of past developments and steer a course around their weaknesses.
A Parenting Program to Prevent Child Maltreatment in China: A Pretest–Posttest-Follow-Up Study
Authors: Zhang Huiping , Yang Haiying , Liu Yu , Xia Xinger , Wang Yixuan , Li Zihui , Li Honglin , Wang Weiwei
Published: November 2023

Purpose: This study aimed to evaluate the outcomes of adapted Parenting for Lifelong Health for Young Children to prevent child maltreatment in the Mainland China. Methods: A pre–post-follow-up study was designed and 54 Chinese parents received the eight-session online parenting intervention between February 4 and March 25, 2023. Results: Forty-one participants (75.9%) completed post-assessment and 36 (66.7%) completed 3-month follow-up assessment. Participants reported reduced child maltreatment, especially in emotional abuse and corporal punishment after the intervention, and the effect was maintained in 3-month follow-up. Improved positive parenting behaviors and decreased child externalizing behaviors were also observed for pre-, post-, and 3-month follow-up assessments. However, there were no significant changes in parental stress, parent–child relationship, parental depressive symptoms, and social support. Conclusions: The online Parenting for Lifelong Health for Young Children program for Chinese parents has shown promise in reducing child maltreatment, improving positive parenting, and decreasing children's problem behaviors, although randomized controlled trials are needed in future studies.
A Cross-Cultural Validation of Psychology of Working Theory With Turkish Working Adults
Authors: Kim Haram J. , Buyukgoze-Kavas Aysenur , Duffy Ryan D. , Perez Gianella
Published: November 2023

Psychology of Working Theory (PWT) is a relatively new vocational theory applicable to various cultural contexts around the world. However, proper examination of the theory within a Turkish context has been limited due to measurement concerns. Thus, in the present studies, we aimed to first translate the most frequently used PWT measures into Turkish by following best practices for scale translation and proceeded to then examine the full PWT model among Turkish working adults. We conducted two separate studies to address our primary aims. In Study 1, we translated the scales and conducted initial validity, and data was collected from 390 Turkish working adults to test the dimensionality and reliability of the scales. Results indicated that both the Economic Constraints Scale and Lifetime Experiences of Marginalization Scale were unidimensional models and the Work Needs Satisfaction Scale had a higher-order model consistent with the original development studies. In Study 2, using these newly translated scales, we examined the full PWT model among a new group of 564 Turkish working adults. Results showed that overall, PWT propositions were largely supported by the sample except for the role of work volition. Limitations and implications of the studies are discussed.
Access to Technology and Digital Literacy as Determinants of Health and Health Care
Authors: Shaw Ryan J
Published: November 2023

Access to and the skills to use technology provide the digital equity necessary for civic and cultural participation, employment, lifelong learning, and access to essential services. However, existing digital disparities and the resultant ‘digital divide’ risk exacerbating health and health-care inequalities. The COVID-19 pandemic amplified these disparities and accelerated the adoption of technology-driven health care such as telehealth, electronic health records, and digital health technologies. Unfortunately, pre-existing disparities influence the adoption and utilization of these technologies, often leaving disadvantaged groups further behind. Efforts toward digital inclusion, access to technology, and digital literacy are necessary to ensure universal access to and meaningful engagement with digital resources. Nurses play a vital role in promoting digital equity, serving as educators, advocates, and digital navigators, guiding patients through the complexities of the digital health landscape.
The Generalized Thurstonian Unfolding Model (GTUM): Advancing the Modeling of Forced-Choice Data
Authors: Zhang Bo , Tu Naidan , Angrave Lawrence , Zhang Susu , Sun Tianjun , Tay Louis , Li Jian
Published: November 2023

Forced-choice (FC) measurement has become increasingly popular due to its robustness to various response biases and reduced susceptibility to faking. Although several current Item Response Theory (IRT) models can extract normative person scores from FC responses, each has its limitations. This study proposes the Generalized Thurstonian Unfolding Model (GTUM) as a more flexible IRT model for FC measures to overcome these limitations. The GTUM (1) adheres to the unfolding response process, (2) accommodates FC scales of any block size, and (3) manages both dichotomous and graded responses. Monte Carlo simulation studies consistently demonstrated that the GTUM exhibited good statistical properties under most realistic conditions. Particularly noteworthy findings include (1) the GTUM's ability to handle FC scales with or without intermediate statements, (2) the consistently superior performance of graded responses over dichotomous responses in person score recovery, and (3) the sufficiency of 10 mixed pairs to ensure robust psychometric performance. Two empirical examples, one with 1,033 responses to a static version of the Tailored Adaptive Personality Assessment System and the other with 759 responses to a graded version of the Forced-Choice Five-Factor Markers, demonstrated the feasibility of the GTUM to handle different types of FC scales. To aid in the practical use of the GTUM, we also developed the R package “ fcscoring.”
‘I am Lil’: Enabling Autistic Voices in Transitions from School to Adult Life through the Co-Creation of a Digital Story
Authors: Ward Asha , Parsons Sarah , Kovshoff Hanna
Published: November 2023

Autistic children’s voices are frequently overlooked, underestimated, and undermined in research and practice such that children are denied agency and their rights as capable knowers. Our digital storytelling work aims to challenge this status quo by co-creating ‘I am’ Digital Stories with and for autistic children and their families. ‘I am’ Digital Stories are short videos (c.3–5 minutes) that provide a strengths-based representation of a child or young person, incorporating their strengths, capabilities, likes, communication and interaction preferences, and how support can be provided. ‘I am’ Digital Stories enable children and young people to present their ‘best selves’ to people who may not know them, especially in transitions between education and other settings. This is Lil’s ‘I am’ Digital Story. Lil was making the move from special school to her adult life which included the possibility of volunteering at a community-based organisation. We worked with Lil to create an ‘I am’ Digital Story that she could share with the organisation. Lil worked closely with her father and the research team to plan, film, and create her Digital Story, which she described as a ‘cool project’. We think that anyone watching the video will get a strong sense of who Lil is, what she likes to do, her skills and interests, and happy personality. Lil is very proud of her Story and we are proud to be able to share her Story here.
Heteronormative silences and queer resistance in queer people’s experiences of eldercare and home
Authors: Siverskog Anna
Published: November 2023

The meaning of home for queer people has been widely empirically explored as well as theorized. Not least has the home been important for the older generations of queer people, who lived in times where their sexualities and gender identities have been criminalized and pathologized and where there have been few public meeting places historically. However, having care needs may blur the lines between private and public and complicate notions of integrity in one’s home. This article is based on qualitative interviews and aims to explore experiences of queer people in a Swedish context who have eldercare services—either people who have home-care-services or who are living in care homes. A queer theoretical framework and reflexive thematic analysis was used. The results illustrate how there is a silence around gender and sexuality in the everyday life within eldercare. This in turn is caused by material conditions where downsizing and effectivization of the eldercare have created pressed working conditions that leave little room for small talk between staff and recipients of care. Norms on age, gender, and sexuality with notions on older people as asexual (as well as cisgender and straight) may play into this silence as well. The boundaries between the private (home) and the public (eldercare) become blurred. This in turn conditions which intimacy practices that become im/possible. Simultaneously, there is a presence of queer resistance as well as of longings for other (queer) futures.
‘They silenced our voices’; a genealogy of the linguistic othering of the Kurds in Iran
Authors: Bazafkan Mohammad
Published: November 2023

Since the turn of the twentieth century, the Kurds in Iran have faced various forms of linguistic exclusion. As part of a genealogical project, this article aims to track the lineages of this exclusion. The linguistic exclusions are inscribed in a field of discursivity, which, tracking one of its lineages, turns our attention to the orientalist interventions. The article discusses two complementary projects: the authentication of the Persian language and the othering of the Kurdish language. These projects were made possible by the hegemony of territorial and linguistic discourses over orientalist studies in Iran. Orientalists proposed a periodization of Iranian languages, dividing them into old, middle, and modern eras, with Persian represented as the sole language that has ever existed throughout history, based on their decoding of ancient manuscripts. Meanwhile, the Kurdish language was completely marginalized, and Persian was represented as the essence of all Iranian languages and, consequently, as the language of all Iranians. As a result, an ontological and epistemic horizon emerged, on which all subsequent instances of othering of the Kurds became possible. Finally, the article also examines the ways in which the Kurds have resisted the linguistic exclusions.
Inclusive Leadership and Workplace Bullying: A Model of Psychological Safety, Self-Esteem, and Embeddedness
Authors: Shafaei Azadeh , Nejati Mehran , Omari Maryam , Sharafizad Fleur
Published: November 2023

Bullying is an adverse workplace phenomenon that requires serious attention by leaders and managers. Drawing upon Social Identity Theory, Optimal Distinctiveness Theory, and Victim Precipitation Theory, this study investigates how inclusive leadership is associated with workplace bullying (WB). It also examines the mediating role of psychological safety and self-esteem as serial mediators in this relationship. Additionally, the moderating role of embeddedness on the link between inclusive leadership and WB is explored. The study used a two-wave time-lagged survey completed by 226 full-time employees. The survey captured employees’ perceptions about themselves, their work environment, and their line managers. Study hypotheses were tested through structural equation modeling. Study findings revealed that inclusive leadership is negatively related to WB. We also found support for the serial mediation of psychological safety and self-esteem in the link between inclusive leadership and WB. Our study also demonstrates that the negative relationship between inclusive leadership and WB is weaker for employees with high embeddedness, thereby uncovering the less explored dark side of embeddedness.
How Presidents Answer the Call of International Capital
Authors: Arnold Christian , Doyle David , Wiesehomeier Nina
Published: November 2023

How do governments manage expectations from international capital keen on pressuring them into adopting market-oriented economic policies during times of crises? Studying executive communication in 267 annual state-of-the-union speeches in 12 Latin American countries between 1980 and 2014 reveals two broad options for strategic position-taking on economic policies. First, when times are dire, presidents not only talk more about the economy and less about social policy, but they also attempt to repurpose other policies as an investment in development. Second, economic turmoil encourages presidents to signal policies, which are appealing to international capital owners. However, while currency crises exert more enduring pressure, the effects of loan crises are more fleeting. Our results are particularly relevant to all who seek to understand how governments use public statements to address pressures from financial markets.
Association Between Chronic Rhinosinusitis and Reflux Diseases in Adults: A Systematic Review and Meta-Analysis
Authors: Aldajani Ahmad , Alhussain Fahad , Mesallam Tamer , AbaAlkhail Mashal , Alojayri Raed , Bassam Hashem , Alotaibi Omar , Alqahtani Mohammed , Alsaleh Saad
Published: November 2023

Background

Over the last few decades, reflux diseases, such as laryngopharyngeal reflux (LPR) and gastroesophageal reflux disease (GERD), have been identified as significant contributors to inflammatory upper aerodigestive tract diseases. Establishing a direct relationship between reflux disease and chronic rhinosinusitis (CRS) is challenging due to the high prevalence of both diseases and their potential for independent coexistence.

Objective

The purpose of this study is to review the existing literature and evaluate the evidence of an association between reflux diseases and CRS.

Methods

A comprehensive electronic search was conducted across multiple databases to identify all studies that investigated the relationship between LPR, GERD, and CRS from January 1, 1950, to June 16, 2022. Only studies with English manuscripts involving adult populations were included, while case series, case reports, and in vitro studies were excluded. The risk of bias was evaluated using The Newcastle-Ottawa Scale for case-control studies and the NIH quality assessment tool for observational cohort and cross-sectional studies.

Results

The search strategy yielded a total of 427 articles, out of which 25 studies examined the correlation between reflux diseases and CRS. The meta-analysis indicated a significant association between the presence of GERD and CRS compared to control groups ( P < .001; CI 3.56 [2.25, 5.65]), as well as significantly higher pH values and pepsin detection in CRS patients when compared to healthy individuals ( P = .003). Furthermore, all studies that evaluated proton pump inhibitor (PPI) therapy in CRS patients reported positive outcomes, with 93% of CRS patients showing improvement on PPIs.

Conclusion

The existing literature provides suggestive evidence of an association between reflux diseases and CRS, with regards to both prevalence and treatment. Nonetheless, further studies are required to confirm this relationship.