bluuebunny/crossref_metadata_2025 huggingface dataset:
ANTIBIOTIC EFFECTS OF SILVER NANOPARTICLES SYNTHESIZED FROM STYCHONS NUX VOMICA ETHYL ACETATE ROOT COLUMN FRACTION AGAINST CLINICAL RESISTANT STAPHYLOCOCCUS STRAINS
Authors:   Department of Biotechnology, Chaitanya (Deemed to be University), Kishanpura, Warangal Urban, 50001, Telangana, India., Praveeen Kumar G. , Sharma Anumula Kireety ,   Department of Biotechnology, Chaitanya (Deemed to be University), Kishanpura, Warangal Urban, 50001, Telangana, India., Murali Krishna Thupurani ,   Department of Biotechnology, Chaitanya (Deemed to be University), Kishanpura, Warangal Urban, 50001, Telangana, India.
Published: March 2022

The present investigation was carried out to evaluate the antibacterial activity of leaf and root silver nanoparticles synthesized using different solvents. According to our studies the AgNPs of Strychons nux vomica synthesized from different solvent extract of root revealed to possess significant activity comparing to the antibacterial activity exhibited by AgNPs of leaf extract. Among the AgNPS tested, AgNPs synthesized using ethyl acetate extract showed highest inhibitory activity comparing to AgNPs synthesized using acetone and methanol extracts. The ethyl acetate extract based AgNPs showed highest zone of inhibition 29.2 mm noted against MRSA. Activity when compared with reference drugs used in the study, was found subtle low with the activity of Dicloxacillin (29.8mm) and high with Clindamycin (28.5mm). Leaf extracts exhibited antibacterial activity against clinically resistant S. aureus species. Among AgNPs tested, ethyl acetate extract, showed high growth inhibition activity against MMSA and MRSA with zone of inhibition 21.5 and 19.9 mm respectively. However, it is failed to inhibit the growth of VRSA. On the other hand, Ag NPs synthesized using acetone extract showed antibacterial activity against all three tested bacterial strains. The zone of inhibition 16.9, 17.8, 15.8mm was noted against MMSA, MRSA, VRSA respectively. Following to acetone extract Ag NPs, methanol extract Ag NPs are also exhibited antibacterial activity. The zone of inhibition 15.5, 12.1, 16.7 noted against MMSA, MRSA, VRSA respectively.
CAREER RECOGNITION OF ISLAMIC ELEMENTARY SCHOOL STUDENTS DURING THE COVID-19 PANDEMIC
Authors:   Research Scholar, Graduate of The Faculty of Guidance and Counseling, Yogyakarta. Yogyakarta State University, Indonesia., Nur Annisa Fitria , Purwanta Edi ,   Professor, Graduate from The Faculty of Guidance and Counseling, Yogyakarta. Yogyakarta State University, Indonesia.
Published: March 2022

Now, the world is being tested by the COVID-19 pandemic. Many aspects of life are affected, one of which is the aspect of education especially in guidance and counseling services. One of the services that was also affected was career guidance services for elementary school students. This study aims to determine the level of career recognition for Islamic elementary school students during the covid-19 pandemic. This study uses a quantitative research design with a survey approach. The research population was all third-grade Islamic elementary school students in Kebumen. The sample consisted of 116 students. The results of this study indicate that the level of career recognition for Islamic elementary school students during the COVID-19 pandemic is in the low category (52%). The latest finding in this study is that the components of job names and work uniforms are the highest career recognition components, while the components of tasks and responsibilities as well as components of requirements and skills are the lowest career recognition components. This low level of student career recognition can actually be improved by providing guidance and counseling services in the career field, especially regarding the introduction of varieties of jobs using various informative techniques and media.
A convolutional neural network method based on Adam optimizer with power-exponential learning rate for bearing fault diagnosis
Authors: Wang Youming , Xiao Zhao , Cao Gongqing
Published: March 2022

The extraction of early fault features from time-series data is very crucial for convolutional neural networks (CNNs) in bearing fault diagnosis. To address this problem, a CNN framework based on identity mapping and Adam optimizer is presented for learning temporal dependencies and extracting fault features. The introduction of four identity mappings allows the deep layers to directly learn the data from the shallow layers, which alleviates the gradient disappearance problem caused by the increase of network depth. A new Adam optimizer with power-exponential learning rate is proposed to control the iteration direction and step size of CNN method, which solves the problems of local minima, overshoot or oscillation caused by the fixed values of the learning rates during the updating of network parameters. Compared to existed methods, the identification accuracy of the proposed method outperformed that of other methods for bearing fault diagnosis.
Energy and reliability analysis of wastewater treatment plants in small communities in Ontario
Authors: Hamza Rania , Hamoda Mohamed F. , Elassar Mohammad
Published: March 2022

This paper presents energy and reliability analyses of eight wastewater treatment plants (WWTPs) operating in small communities in Ontario, Canada, with rated capacities ranging from 60 to 4,400 m3/d. Five different treatment technologies were investigated, namely, rotating biological contactor (RBC), sequencing batch reactor (SBR), membrane bioreactor (MBR), lagoon, and extended aeration activated sludge process (EAAS). Energy benchmarking based on key performance indicators (KPIs) was used to quantify the specific consumption of energy in WWTPs per unit of the pollutant removed. The overall annual electrical energy consumption was correlated to the volume of treated wastewater, the population equivalent, and the amounts of TSS and BOD removed. The RBC plants showed a distinctive advantage for all energy KPIs assessed, while SBR plants yielded the highest values of energy KPIs. Analyses of the expected percentage of compliance with discharge standards and the coefficient of reliability (COR) based on the WWTPs' performance records showed that few WWTPs were able to achieve reliability levels over 95%, considering the mandated discharge standards under the current operating and maintenance conditions. Within each technology, the treatment train, operating conditions, maintenance level, and age of infrastructure were important elements that contributed to the large variability observed.
Usage of Traditional, Complementary and Alternative Medicine and Related Factors among Patients Receiving Healthcare in Lesotho
Authors: Mokhesi Thuso , Modjadji Perpetua
Published: March 2022

Background:

The use of Traditional, Complementary and Alternative Medicine (TCAM) is becoming apparent among many populations, particularly those suffering from chronic illnesses. Although this is a concern to clinicians, especially on safety and potential health risks, there is a paucity of data on TCAM usage and related factors among patients receiving healthcare in Lesotho.

Objective:

To determine the prevalence of TCAM usage and associated factors among patients receiving healthcare in a health facility in Lesotho.

Methods:

A cross-sectional study was conducted among 336 patients receiving healthcare in the Maseru district, Lesotho. A validated questionnaire was used to collect data on demographic and lifestyle factors, disease and treatment profile, treatment challenges, and TCAM usage, reasons/purpose, disclosure, healing system, duration, costs, sources and types. Multiple logistic regression analysis was used to ascertain any relationships with TCAM usage.

Results:

The response rate was 98%. The mean age of participants was 51±16years. Unemployment (63%) was high and, over half of the patients (59%) attained primary school education. Patients were mostly on treatment for sexually transmitted infections (42%), non-communicable diseases (30%) and comorbidities (19%), with 98% taking prescribed medication. TCAM usage was 15% with Traditional Herbal Medicine (THM) being the most widely used. Common THM were Dicoma Anomala, Eriocephalus Punctulatus, Aloiampelos Striatula, Artemisia Afra and Allium Sativum, obtained from the traditional healers (53%), followed by relative/friends (16%), pharmacists (13%), open market (12%), and accessed at low costs. TCAM was used to treat infectious (23%) and non-infectious (77%) diseases, but disclosure (7%) to healthcare workers was low. Multivariate analysis showed that TCAM usage was associated with self-employment AOR=6.3, 95%CI; 2.57-15.21, and being a student AOR=3.6, 95%CI; 0.99–12.71.

Conclusion:

THM was the most widespread type of TCAM among the study population in Lesotho. Prospective studies on TCAM usage are necessary to inform proper practice and safety in Lesotho.
Structure, Stability, and Electronic Feature Analyses of Substrates (Methyl Orange and Vanadium Oxide)-Surfactant (Triton X-100) Complex: A Computational Insight
Authors: Vemuri Rama Satya Sarveswara Srikanth , Pandey Sarvesh Kumar , Khanal Govinda Prasad
Published: March 2022

Aims:

The objective of the present work is to understand the structural stability (i.e., H-bonding and other weak noncovalent interactions) and electronic features of new model substrates, such as methyl orange (MO), vanadium oxide (V), surfactants as Triton-X100 (TX-100), and their allied substrate-surfactant model complexes (MO-V, MO-TX100, V-TX100, and (MO-V)-X100) with the deployment of density functional theory (DFT) method followed by electronic structure calculations and quantum theory of atoms in molecules (QTAIM) approaches.

Background:

Significant interactions appear to play a major role in reducing the energy gap between the model substrates Methyl Orange (MO)/Vanadium Oxide (V)/MO-V) and surfactant/catalyst Tri-ton-X100 (TX-100) and enhancing the catalytic behaviour of the surfactant/catalyst TX-100.

Objective:

The main objective of the present report is to conduct computational experiments on the designing, characterization, structure, stability, and electronic feature analyses of substrates-surfac-tant model complexes constituted from Methyl Orange (MO), Vanadium Oxide (V), Triton-X100 (TX-100) units which could indeed help in synthesizing novel materials as a catalyst, controlling the reaction path by tuning such interesting interactions between a catalyst/surfactant and substrate.

Methods of Computational Calculations:

The quantum chemical calculations have been performed using Gaussian 09 electronic structure calculations program. B3LYP exchange-correlation functional in conjunction with 6-31G(d,p) basis set has been employed along with the incorporation of the ef-fective core potential (ECP) based basis set for vanadium ‘V’ atom.

Results:

In the present report, the computational experiments have been conducted to probe the struc-tural, stability, and electronic features of four substrates-surfactant model complexes (SSMC) [MO-V, MO-TX-100, V-TX-100, and (MO-V)-TX-100] acquired from the substrates MO and V or the combination of both as MO-V and surfactant/catalyst TX-100. The HOMO-LUMO energy gap of the (MO-V)-TX-100 SSMC complex (0.679 eV) is found to be the lowest among all [MO-V (3.691 eV), MO-TX-100 (3.321 eV), and V-TX-100 (3.125 eV)] SSMCs, which appears mainly due to the presence of surfactant/catalyst (TX-100), thus showing its high reactivity/catalytic behaviour.

Conclusion:

The calculated binding energy, change in Gibbs free energy, natural charges, and the QTAIM based topological parameters show the most favourable stabilization (H-bonding and non-covalent interactions, including metal/non-metal bonding) and interactions in the (MO-V)-TX-100 SSMC, indicating the presence of the TX-100 surfactant.
FIRM VALUE DETERMINATION WITH INFLATION AND EXCHANGE RATE AS A MODERATING VARIABLE (Study on the Manufacturing Industry Recorded in Indonesian Sharia Stock Index)
Authors: Soekapdjo Soeharjoto , * Miyasto , Mariyanti Tatik
Published: March 2022

Purpose - Aims of this research are to determine the factors that influence the firm value of the manufacturing industry listed on the Indonesia Sharia Stock Index.
 
Design/methodology/approach - Used panel data regression method from 2013-2018, then obtained 30 manufacturing industry companies after purposive sampling. Syariah stock investors who rationally and religiously behave are accommodated in the variables used. The dependent variable is firm value and the independent variable are return on equity, current ratio, debt to equity ratio, total assets turn over, Islamic social reporting, with the exchange rate and inflation as the moderating variable.
 
Finding - Results show that return on equity with inflation as a moderating variable has a positive effect on firm value. Islamic social reporting has a positive effect on firm value. Debt to equity ratio with the exchange rate as a moderating variable has a negative effect on firm value. The current ratio and total assets turnover are not significant to firm value.
 
Practical Implication - To increase the firm value, it is necessary to improve human resources and the application of environmentally friendly technology, planning in production and expansion, transparency and application of sharia principles, professional and fair managers.
 
Originality/value - This study combines the company’s financial ratios, Islamic social reporting, and macroeconomic conditions that are beyond management control. Tobins’ Q is used to the corporate values approach. All of these, reflect that firm value is influenced by company performance, society, and government.
 
 
Keywords - Firm Value, Financial Ratio, Islamic Social Reporting, Sharia Enterprise Theory, Macroeconomics, Indonesia Sharia Stock Index
DISTRIBUTION OF CREDIT FOR MICRO, SMALL, AND MEDIUM ENTERPRISES OF MANDIRI BANK SINAKMA MARKET JAYAWIJAYA
Authors: Ali Muhammad , Haryati Tati , * Aprilia
Published: March 2022

AbstractThe purpose of KUR is to increase access to finance for Small and Medium Enterprises (UKM) to financial institutions with a guarantee scheme through the People's Business Credit (KUR). The KUR guarantee is provided in order to increase UMKM access to sources of financing in order to encourage national economic growth. Bank Mandiri is one of the State-Owned Enterprises (BUMN) that was established to assist UMKM players in realizing their business and maintaining business continuity. The results showed that with the existence of a program from the government through the distribution of People's Business Credit which was channeled through PT. Bank Mandiri KCP MMU Wamena Pasar Sinakma for the welfare of Micro, Small, and Medium Enterprises (UMKMÂ Keywords: People's Business Credit, UMKM
ANALYSIS OF ACCEPTANCE OF ACCOUNTING INFORMATION SYSTEM IMPLEMENTATION BASED ON ELECTRONIC PAYMENT USING THE UTAUT MODEL
Authors: Aviyanti Richo Diana , Saraswati Erwin , Prastiwi Arum
Published: March 2022

Purpose — This study aims to examine and analyze the effect of performance expectancy, effort expectancy, social influences, and facilitating conditions on the actual use of electronic payment-based accounting information systems.
Design/methodology/approach — Data obtained through online questionnaires filled out by 247 active users of electronic payment systems. The analysis method used is a Structural Equation Modeling/SEM with a Partial Least Square/PLS test tool.
Findings — Empirical evidence shows that performance expectancy, effort expectancy, social influences, and facilitating conditions significantly affect electronic payment systems' actual use.
Practical implications — Electronic payment platforms are recommended to provide an electronic payment application system that can be used easily and usefully. The platform can use these results as a reference regarding customer behavior in using an electronic payment-based accounting record system
Originality/value — This study uses UTAUT which is modeled directly on actual use.
Keywords — Accounting; System; Electronic Payments; UTAUT; and Actual Use.
Paper type — Positive Paradigm Research Paper
Pelatihan Penyusunan Perangkat Pembelajaran IPA Bagi Guru SD dalam Rangka Menghadapi Tantangan Revolusi Industri 4.0
Authors: Syamsuri M Mahfudz Fauzi , Tias Ika Wulandari Utamining , Izzatika Amrina
Published: March 2022

Sejak bergulirnya revolusi industri (RI) 4.0 tidak hanya sektor industri saja yang terdampak, sektor pasar tenaga kerja dan pendidikan juga turut terdampak. Penyiapan SDM yang berkualitas dan memiliki keterampilan-keterampilan abad XXI agar dapat menghadapi tantangan RI 4.0 perlu dilakukan sejak di bangku SD, salah satunya melalui pembelajaran IPA. Kegiatan ini dilakukan dengan tujuan melatih guru-guru SD di Kota Metro Provinsi Lampung dalam menyusun perangkat pembelajaran IPA yang melatihkan keterampilan-keterampilan abad XXI. Kegiatan ini dilakukan dengan metode ceramah, workshop, kegiatan mandiri, dan presentasi. Dari kegiatan ini diperoleh nilai rerata n-gain sebesar 0,780 dengan kategori tinggi dan 85% guru peserta kegiatan dinyatakan terampil dalam menyusun perangkat pembelajaran IPA yang melatihkan keterampilan-keterampilan abad XXI. Kata kunci: revolusi industri 4.0, keterampilan abad XXI, perangkat pembelajaran IPA SD AbstractSince the onset of the industrial revolution (IR) 4.0, not only the industrial sector has been affected, but also the labor market and education sectors have been affected. Preparation of the qualified human resources and the 21st-century skills to be able to deal with the challenges of IR 4.0 needs to be done in elementary school, one of which is through natural science learning. This activity is carried out to train elementary school teachers in the Metro City Lampung Province for making natural science learning instruments that practice 21st-century skills. This activity is carried out by lecturing, workshops, independent activities, and presentations. From this activity, an average n-gain value of 0.780 was obtained with a high category and 85% of the teachers participating in the activity were declared skilled in compiling science learning tools that train the 21st-century skills. Key words: industrial revolution 4.0, the 21st-century skills, natural science for elementary school learning instruments
Pendampingan Belajar Bangun Datar Melalui Media Tangram 7
Authors: Runisah Runisah , Nandang Nandang , Ismunandar Denni
Published: March 2022

Pada masa pandemi covid-19 hampir seluruh siswa pada tingkat sekolah dasar melaksanakan pembelajaran secara online. Hal ini berdampak pada pengetahuan siswa sekolah dasar tingkat rendah pada materi tertentu. Tujuan pengabdian ini adalah memperkuat pemahaman siswa pada materi bangun datar melalui pendampingan belajar siswa sekolah dasar pada kelas 2 dan 3. Partisipan pada pendampingan ini dibatasi hanya 5 peserta. Hal ini dilakukan karena mematuhi peraturan pemerintah untuk menghindari kerumunan. Pengambilan partisipan dilakukan dengan memilih siswa di sekitar  rumah salah satu tim pengabdian. Metode yang digunakan pada saat pendampingan adalah ceramah, diskusi dan praktek. Media tangram digunakan untuk membantu siswa memahami materi bangun datar. Bangun datar yang terdiri dari bangun segitiga dan segi empat yang dapat disusun dalam beberapa bentuk membuat siswa tertarik untuk mengutak – atik bentuk lainnya dari bangun datar tersebut. Hasil pengabdian ini adalah adanya peningkatan pengetahuan siswa pada materi bangun datar. Selain itu siswa merasa senang dengan adanya kegiatan pendampingan belajar ini karena siswa dapat menyusun bentuk – bentuk hewan dari bangun datar.Kata kunci: Tangram, Pendampingan, Pengetahuan.
EFEKTIFITAS PENGGUNAAN MEDIA QUIZIZZ FITUR GAMEFIKASI MELALUI DARING PADA PEMBELAJARAN PSPTKR MATERI KOPLING DAN TRANSMISI DI SMK N 2 WONOSARI
Authors: Jumanto Jumanto Jumanto
Published: March 2022

Penelitian ini bertujuan untuk mengetahui; (1) efektifitas penggunaan media quizizz fitur gamefikasi melaui daring pada pembelajaran PSPTKR materi kopling dan transmisi ditinjau dari hasil belajar peserta didik (2) respon peserta didik terhadap penggunaan media quizizz fitur gamefikasi. Penelitian yang digunakan merupakan penelitian deskriptif dengan pendekatan kuantitatif.  Subjek penelitian  ini  adalah 104  peserta didik  kelas  XI TKR. Penelitian ini menggunakan instrumen (1) tes ulangan quizizz (2) kuesioner peserta didik (3) lembar pedoman wawancara sebagai pendukung hasil kuesioner respon peserta didik. Hasil dari penelitian ini adalah (1) dilihat dari kenaikan hasil belajar peserta didik selama menggunakan media quizizz fitur gamefikasi mata pelajaran PSPTKR materi kopling dan transmisi dimana sebanyak 80% siswa tuntas KBM materi kopling dan sebanyak 88,54% siswa tuntas KBM materi transmisi. Sehingga penggunaan media quizizz fitur gamefikasi sangat efektif diterapkan pada pembelajaran daring. (2) respon peserta  didik terhadap penggunaan media quizizz fitur gamefikasi dengan hasil siswa mengalami kemudahan dalam pemahaman materi, tidak membosankan, dapat meningkatkan motivasi belajar dan membuat siswa dapat berfikir kritis dengan presentase secara keseluruhan yaitu sebesar 69%.
Accurate numerical prediction of thermo-mechanical behaviour and phase fractions in SLM components of advanced high strength steels for automotive applications
Authors: Abburi Venkata Kiranmayi , Uppaluri Rohith , Schob Bernd , Zopp Camilo , Kordass Richard , Bohlen Jan , Höfemann Matthias , Kasprowicz Marcin , Pawlak Andrzej , Chlebus Edward
Published: March 2022

Conventional crash absorber in automotive applications, so called crash boxes are fabricated via deep drawn sheet metal resulting in significant lead times and costs. Laser Powder Bed Fusion processes, like Selective Laser Melting (SLM) offer an attractive alternative for the fabrication of crash parts while eliminating any need for costly forming dies and reducing the lead times, provided required material properties are achieved. Reliable numerical simulation model to predict the SLM build process with greater spatial resolution and accuracy is indispensable to understand the process further in order to ensure its applicability to crash structures. In this paper, an improved simulation methodology for SLM process is presented to predict the material behaviour via temperature, deformation, hardening, flow stress and phase fractions throughout the component with increased accuracy and greater resolution. To achieve desired spatial resolution, the equivalent layers are subdivided into individual tracks, which are then deposited sequentially to simulate the printing process. The material is a medium manganese (7­-8 %) transformation induced plasticity (TRIP) steel with austenite and martensite primary phases. The multiple solid-state phase transformation cycles undergone by the material are modelled in the simulation and the final phases are predicted. The results indicate improved accuracy and higher resolution in predictions for temperature, phase fractions and deformation.
Remodeling the Medication Collection Process With Prescription in Locker Box (PILBOX): Prospective Cross-sectional Study
Authors: Lim Jit Fan Christina , Boon Kwang Goh , Chee Wing Ling Vivian , Woh Peng Tang , Goh Qiuling Bandy
Published: March 2022

Background

Traditionally, patients wishing to obtain their prescription medications have had to physically go to pharmacy counters and collect their medications via face-to-face interactions with pharmacy staff. Prescription in Locker Box (PILBOX) is a new innovation allowing patients and their caregivers to collect medication asynchronously, 24/7 at their convenience, from medication lockers instead of from pharmacy staff.

Objective

This study aimed to determine the willingness of patients and caregivers to use this new innovation and factors that affect their willingness.

Methods

This prospective cross-sectional study was conducted over 2 months at 2 public primary health care centers in Singapore. Patients or caregivers aged 21 years and older who came to pharmacies to collect medications were administered a 3-part questionnaire face-to-face by trained study team members after they gave their consent to participate in the study.

Results

A total of 222 participants completed the study. About 40% (89/222, 40.1%) of participants were willing to use PILBOX to collect their medications. Among participants who were keen to use the PILBOX service, slightly more than half (47/89, 53%) were willing to pay for the PILBOX service. Participants felt that ease of use (3.5 [SD 1.2]) of PILBOX was the most important factor affecting their willingness to use the medication pickup service. This was followed by waiting time (3.4 [SD 1.3]), cost of using the medication pickup service (3.0 [SD 1.4]), and 24/7 accessibility (2.6 [SD 1.4]). This study also found that age (P=.01), language literacy (P<.001), education level (P<.001), working status (P=.01), and personal monthly income (P=.01) were factors affecting the willingness of patients or caregivers to use PILBOX.

Conclusions

Patients and caregivers are keen to use PILBOX to collect their medications for its convenience and the opportunity to save time if it is easy to use and not costly.
Feasibility of Using Electronic Health Records for Cascade Monitoring and Cost Estimates in Implementation Science Studies in the Adolescent Trials Network for HIV/AIDS Interventions
Authors: Dark Tyra , Simpson Kit N , Gurung Sitaji , Pennar Amy L , Chew Marshall , Naar Sylvie
Published: March 2022

Background

One of the most difficult areas in the fight against HIV/AIDS is reaching out to youth aged 13 to 24 years. The proportion of youth living with HIV/AIDS on antiretroviral therapy (ART) and who are virally undetectable is low, highlighting significant challenges for reaching the Joint United Nations Program on HIV targets.

Objective

This study aimed to assess the feasibility of obtaining key clinical indicators and monitoring treatment, viral suppression, and retention components of the youth HIV treatment cascade in Adolescent Trials Network for HIV/AIDS Interventions clinics using electronic health record (EHR) downloads and to provide baseline characteristics for the study participants.

Methods

EHR data were systematically obtained from multiple clinical sites and used to meaningfully capture clinical characteristics, initiation of antiretrovirals, and retention in care, which are part of the Centers for Disease Control and Prevention’s 4 continuum of care measures. In addition, this study used standard cost values attached to Current Procedural Terminology codes to estimate the cost per visit.

Results

Only 2 of the 4 Centers for Disease Control and Prevention treatment cascade measures were assessed using routine EHR data. EHR data are not adequate for monitoring HIV testing or linkage to care because denominator data are not available. However, the data work well for measuring ART initiation and adequately for retention in care. The sites were broadly able to provide information for the required data. However, in most cases, these data are insufficient for identifying patterns of missed appointments because such misses are not captured in the EHR system. Sites with good access to data management resources can operate more efficiently for cascade monitoring study purposes.

Conclusions

Data other than EHRs are needed to measure HIV testing and linkage to youth care. EHR data are useful for measuring ART initiation and work moderately well for measuring retention in care. Site data management resources should be part of the selection process when looking for site partners for clinical studies that plan to use EHR data. Study planners should determine the feasibility of additional funding for organizations in need of additional information technology or data management resources.
Teaching telepsychiatry skills: building on the lessons of the COVID-19 pandemic to enhance mental health care in the future (Preprint)
Authors: Smith Katherine , Torous John , Cipriani Andrea
Published: March 2022

UNSTRUCTURED

COVID-19 has accelerated the use of telehealth and technology in mental health care, creating new avenues to increase both
access to and quality of care. As video visits, synchronous telehealth, become more routine the field is now on the verge of
embracing asynchronous telehealth with the potential to radically transform mental health. But sustaining the use of basic
synchronous telehealth let alone embracing asynchronous telehealth requires new and immediate effort. Programs to increase
digital literacy and competencies among both clinicians and patients are now critical to ensure all parties have the knowledge,
confidence, and ability to equitably and actually benefit from emerging innovations. This editorial outlines the immediate potential
as well as concrete steps towards realizing this potential of a new, more personalized, and scalable mental health system.
Counterfeit Purchase Intention of Fashion Brands: The Personal Values and Social Aspect of Consumers as Determinants
Authors: Mayasari Iin , Haryanto Handrix Chris , Wiadi Iyus , Wijanarko Adrian Azhar , Abdillah Willy
Published: March 2022

Counterfeiting has become a growth industry in Indonesia. Consumers in Indonesia tend to find counterfeit products very easily, especially fashion products. The aim of this quantitative study is to analyze personal values and social factors toward counterfeit items and the intention to purchase counterfeit goods in Indonesia, with a focus on fashion products. The study also aims at analyzing the influence of novelty seeking, integrity values, and status consumption on people’s attitudes toward counterfeit goods. Furthermore, this study also addresses the influence of perceived risk, information susceptibility, physical vanity, and vanity-achievement on the intention to purchase counterfeit products. One hundred and ninety-three respondents were included in our study after survey questionnaires had been distributed in Indonesia. The respondents were 19 to 44 years old, living in Jakarta, Tangerang, Bogor, Bekasi, Yogyakarta, Bandung, Medan, Jambi, Batam, Pekanbaru and Samarinda, all of which are larger cities in Indonesia. Data were analyzed using partial least squares. The results of the study showed that the attitude toward counterfeit items was the most important factor in the willingness to purchase counterfeit goods. Novelty seeking, integrity, status consumption, and information susceptibility were also important determinants of people’s attitudes toward counterfeit products. Perceived risk, physical vanity, and achievement vanity were found to have an insignificant relationship with the intention to purchase counterfeit products .  This study also has an impact on marketing strategies. One of them is marketers can offer very prestigious brands to reduce the trade in counterfeit luxury brands.
Efektivitas Pengobatan pada Pasien Penyakit Paru Obstruksi Kronis (PPOK) di Rumah Sakit Wilayah Yogyakarta
Authors: Sari Chynthia Pradiftha , Hanifah Suci , Rosdiana Rosdiana , Anisa Yuni
Published: March 2022

Chronic Obstructive Pulmonary Disease (COPD) is a complex respiratory disorder that requires multiple approaches to assess treatment response, no specific therapy can stop the progression of disease cure. This study aimed to measure the response of COPD treatment in outpatients at Hospitals in Yogyakarta. The study was designed descriptive observational cross-sectional involved  COPD outpatients in July 2018 - June 2019 (N = 156). Inclusion criteria the subjects: age> 40 years, without other respiratory diseases (asthma, lung cancer), took theophylline for at least the last one month, complete the CAT questionnaire, and sign an informed consent. Data collected were characteristics of respondents, treatment profile (exacerbation, maintenance), and response therapy data. Evaluation of treatment response was measured using the COPD Assessment Test (CAT) questionnaire and classified the response into effective, quite effective, and not effective. These data were then presented in form of percentage distribution. The results showed that an exacerbation study with single bronchodilator 39.10%, and a combination of bronchodilator with other bronchodilators 60.90%, most LABA-ICS / LAMA rescue therapies (48.72%). Results of evaluation the use of LABA-ICS / LAMA / Methylxanthine (18.59%), LABA-ICS / LAMA / Methylxanthine/ Mucolytic (11.54%), LABA-ICS / LAMA / SABA / Methylxanthine / Mucolytic (9.62%) )) gave a fairly effective treatment response (CAT score ≥10-19) 50.64%, effective (CAT score <10) 47.43%, ineffective (CAT score ≥20) 1.93%.
Pengaruh Pemberian Leaflet Terhadap Pengetahuan Masyarakat tentang Obat Tradisional
Authors: Dewi Ratna Sari , Aryani Fina , Hidayani Yelly
Published: March 2022

Obat tradisional yang mengandung Bahan Kimia Obat (BKO) saat ini masih banyak ditemukan sehingga masyarakat harus waspada dengan meningkatkan pengetahuan tentang obat tradisional seperti informasi minimal yang perlu diketahui ketika membeli sediaan obat tradisional dan cara membedakan sediaan obat tradisional yang legal ataupun ilegal. Penelitian ini bertujuan untuk mengetahui efek pemberian media edukasi leaflet terhadap pengetahuan masyarakat tentang obat tradisional di wilayah Simpang Tiga Kota Pekanbaru. Pengaruh media leaflet dinilai berdasarkan perubahan skor pengetahuan. Metode penelitian yang digunakan adalah quasi experiment dengan rancangan non randomized control group pretest and posttest design yang dilakukan terhadap 70 responden kelompok kontrol (tanpa pemberian leaflet) dan 70 responden kelompok perlakuan (dengan pemberian leaflet). Sampel penelitian adalah masyarakat Simpang Tiga yang dipilih menggunakan teknik convenience sampling sesuai kriteria inklusi dan eksklusi. Instrumen yang digunakan berupa kuesioner untuk mengukur pengetahuan yang telah diuji validitas (diperoleh 17 pertanyaan yang valid) dan reliabilitasnya (r=0,929). Analisis data menggunakan uji Wilcoxon dan Mann-Whitney. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan pada perubahan skor pengetahuan responden kelompok kontrol dan kelompok perlakuan dengan p value = 0,000. Dapat disimpulkan bahwa pemberian media leaflet sangat berpengaruh terhadap pengetahuan masyarakat tentang obat tradisional di wilayah Simpang Tiga Kota Pekanbaru. Tenaga Kefarmasian harus aktif dalam memberikan edukasi kepada masyarakat tentang obat tradisional dan sebaiknya menggunakan media seperti leaflet.
Analisis Korelasi Gula Darah Puasa, HbA1c, dan Karakteristik Partisipan
Authors: Hasanah Nidaul , Ikawati, Apt. Zullies
Published: March 2022

Hemoglobin A1c (HbA1c) measurement is recommended as the gold standard in long-term blood sugar monitoring the diabetes patients because the fasting blood sugar (FBG) pattern alone cannot provide accurate information regarding the blood sugar variability true picture in type 2 Diabetes mellitus (T2DM) patients. However, many patients have limited access to HbA1c testing for financial reasons. It is necessary to know the relationship between HbA1c and GDP, and the factors that influence it, especially the research participant characteristics. This analytic observational study with a cross-sectional design involved 100 participants from T2DM patients in the hospital, outpatient clinics, and communities in Yogyakarta Province from January-May 2020. The HbA1c and FPG measurement was carried out using capillary blood samples by the research team. Characteristic data were obtained through direct interviews with participants, then analyzed using SPSS version 25 for windows, using the chi-square, Kolmogorov-Smirnov, and Spearman's rho test. The results showed that FPG was significantly positively correlated with HbA1c with moderate correlation criteria (r=0.74, P-value<0.0001). FPG showed a significant negative correlation to the glucometer ownership variable (r=-0.22, P-value= 0.04), and was independent of other parameters. Meanwhile, HbA1c significantly negatively correlated with age (r=-0.26, P-value=0.01), education level (r=-0.22, P-value=0.04), comorbidity (r=-0, 24, P-value=0.02), routine drug consumption (r=-0.29, P-value=0.01) and the ownership of glucometer (r=-0.26, P-value=0.01), but independent of gender, smoking status, daily menu, and physical exercise. It can be concluded that both GDP and HbA1c can be used as a reference for assessing glycemic status.
Hubungan Drug Related Problems (DRPs) dan Outcome Pengobatan Pada Pasien Tuberkulosis Dengan Diabetes Melitus
Authors: Fortuna Tista Ayu , Rahmawati Fita , Yasin Nanang Munif
Published: March 2022

Tuberkulosis dan Diabetes adalah kondisi penyakit yang saling berkaitan sehingga diperlukan terapi agresif untuk mengatasinya. Adanya Drug Related Problems (DRPs) yang terjadi dapat mempengaruhi outcome pengobatan pasien Tuberkulosis-Diabetes Mellitus (TB-DM). Penelitian bertujuan untuk menganalisis hubungan terjadinya DRPs dan outcome pengobatan pasien TB-DM. Penelitian menggunakan rancangan kohort retrospektif. Pengambilan sampel dilakukan menggunakan consecutive sampling  melalui catatan rekam medik pasien TB-DM pada 9 Puskesmas di Kota Malang. Sejumlah 100 kasus pasien TB-DM yang menjalani pengobatan  tahun 2017 hingga 2020 yang memenuhi kriteria inklusi selanjutnya  dibagi menjadi dua kelompok, yaitu kelompok yang mengalami DRPs dan kelompok pasien yang tidak mengalami DRPs sejumlah masing-masing 48 pasien dan 52 pasien. Jenis DRPs mengikuti klasifikasi Cipolle 2004. Outcome pengobatan dinilai berdasarkan hasil tes BTA (Bakteri Tahan Asam) pada akhir masa pengobatan bulan kedua. Analisis data menggunakan statistik Chis-quare dilanjutkan analisis multivariat untuk menganalisis adanya variabel perancu yang diprediksikan dapat mempengaruhi outcome pengobatan pada penelitian ini. Hasil penelitian menunjukkan terdapat hubungan antara kejadian DRPs dan outcome pengobatan pasien (p-value <0,05). Pasien dengan DRPs 5,41 kali lebih beresiko mengalami kegagalan terapi dibandingkan dengan pasien yang tidak mengalami DRPs (RR 5,417; 95% CI, 1,994-14,713). Keterlibatan farmasi klinis sangat diperlukan untuk mencegah dan menyelesaikan masalah terkait obat serta monitoring pengobatan pada pasien TB-DM yang ada di Puskesmas sehingga luaran pengobatan menjadi optimal
Antidiabetic Regimen and Factors Associated with Glycemic Control in Patients with Type 2 Diabetes mellitus in Public Health Centers in Jakarta: A Cross-Sectional Study
Authors: Wulandari Nora , Maifitrianti Maifitrianti , Muthi’ah Fadilla , Disya Nava Nur
Published: March 2022

Background:The glycemic control of diabetes mellitus patients is affected by many factors, including its antidiabetic regimen. Objectives: This study aimed to describe the antidiabetic regimen used in patients with T2DM in the public health centres in Jakarta and to evaluate the association of the regimens and other factors with glycemic control. Methods:This was a cross-sectional study conducted in thirteen public health centres in Jakarta with HbA1C of ≤ 7% indicating good glycemic control and > 7% poor glycemic control. The univariate analysis tests were used to analyze factors that potentially associate with glycemic control. Association between antidiabetic regimen and glycemic control were done by Pearson chi-square test and Fisher exact test.Results:Combination of sulfonylureas and biguanides was the most frequent antidiabetic regimen prescribed to the patients. Univariate analysis showed that age, duration of T2DM, route of administration, number of antidiabetics, and number of other daily regular drugs significantly (P<0.05) related to glycemic control.Sulfonylurea and biguanides as monotherapy were significantly (P<0.05) associated with good glycemic control. Conclusion:Sulfonylurea and biguanide as monotherapy were found to be associated with good glycemic control. In contrast, the combination of and with the two did not show the same.
Parental Use of Internet to Navigate Online Health Information for Their Children: An Indonesian Context
Authors: Ramadaniati Hesty Utami , Andayani Nurita , Azizah Zata Yumni
Published: March 2022

Internet-resourced health information becomes increasingly common amongst parents before doctor consultation. This study aimed to explore the demographics of online health information-seeking parents and the type of information on children’s healthcare needs and the relationship between the demographics and the online sources. A cross-sectional study was conducted at two Primary Health Centers (PHC) in Jakarta. The respondents were parents of acutely ill children seeking online health information before visiting PHC. A validated questionnaire was distributed to the respondents. Parents’ demographics and type of information were analyzed descriptively. The relationship between the demographics and the information source was tested using the Chi-Square test. 478 respondents were participating in this study where most of the respondents were mothers (75.1%), aged 26-35 years (57.7%), and had 1-2 children (70.7%). Most of them were high-school graduates (64.9%) and unemployed (49.6%). Google (61.5%) was predominantly the most frequently used digital media, followed by websites run by doctors (21.9%). The most sought information included illness causes, transmission probability, treatment, and medicines’ side effects. There was no significant relationship between any demographics and the types of online sources. In conclusion, illness-related basic information is used by most parents to be informed before seeing doctors. The link between parents’ characteristics and the selection of digital media could not be determined.
Formulation and Antifungal Activity of Piper betle L. Leaf Extract in Emulsion Gels Against Candida albicans
Authors: Putranti Widyasari , Asterina Chairisty , Witasari Hardi Astuti
Published: March 2022

Candidiasis is the most common fungal infection in humans and is a form of primary and secondary infections of C. albicans. Betel (Piper betle L.) leaf extract has been reported to exhibit efficacious antifungal effects against C. albicans. Emulsion gels, a type of topical dosage form, can deliver hydrophilic and hydrophobic drugs and perform multiple and controlled releases. This research aimed to determine the antifungal activity and physical properties of emulsion gels formulated from betel leaf extract. The dried betel leaves were extracted by maceration with alcohol 95%. Then, with different concentrations (1, 2, and 4%), the extract was formulated into emulsion gels. These dosage forms were later subjected to antifungal activity testing against C. albicans using the cup plate diffusion method that involved Mycoral Cream® for comparison. In this test, the intensity of the activity was determined by measuring the diameter of the formed inhibition zone. The second test evaluated the physical characteristics of the dosage forms, including organoleptic properties, pH, adhesion, dispersion, and viscosity. These data were analyzed using the Mann-Whitney method, and the conclusion was withdrawn from describing the results quantitatively. The reaction yield of the extraction was 9.702%. The analysis results showed that emulsion gels containing 1, 2, and 4% of betel leaf extract created zones of inhibition with diameters of 5.3 ± 0.29, 6.2 ± 0.29, and 10.2 ± 0.41 mm, respectively. As for the physical properties, they differed in pH (6.39 ± 0.120, 6.17 ± 0.132, 5.66 ± 0.123), spreadability (1.849 ± 0.45, 1.816 ± 0.051, 1.771 ± 0.092 g.cm.s-1), adhesion (110 ± 10.8, 126.3 ± 8.5, 142.7 ± 13.50 seconds), and viscosity (2640.35, 1992.95, 2162.12 cps), respectively. The betel leaf emulsion gels exhibited antifungal activity against C. albicans (p <0.05) and met the physical requirements of semi-solid dosage forms.
Sunscreen Activity of Fraction n-hexane, Chloroform, and Eethyl Acetate of Ethanol 96% Flamboyan Leaf (Delonix regia. Raf) Extract
Authors: Tjitda Putra Jiwamurwa Pama , Nitbani Febri Odel , Bangko Maria Kristina
Published: March 2022

The sunscreen test of fraction n-hexane, chloroform, and ethyl acetate of ethanol 96% flamboyant leaf (Delonix regia. Raf) extract had been performed. This research begins the extraction of a flamboyant leaf using 96% ethanol. Extraction used the maceration method. The extract is fractionation with some solvents such as n-hexane, chloroform, and ethyl acetate. Each fraction was identified secondary metabolite and sunscreen test involving SPF, %Te, and %Tp measurement using UV-Vis Spectrophotometer. The result of phytochemical screening exhibited flavonoids, alkaloids, saponins, tannins, and phenolics in ethyl acetate fraction. n-hexane and chloroform fraction don't show saponins and flavonoid content. The sunscreen test shows that chloroform fraction has good protection power toward UV light with SPF, %Te, and %Tp value is 54.27±0.462, 7.46±0.473, and 12.83±0.047 in 250 mg/L, respectively.
Synergistic Interaction of Ethyl Acetate Fraction of Melastoma malabathricum L. Leaves Combined with Ciprofloxacin and Gentamicin Against Eschericia coli Isolate for Diabetic Foot Ulcer Patients
Authors: Pratiwi Liza , Sari Rafika , Apridamayanti Pratiwi
Published: March 2022

Melastoma malabathricum leaves have active compounds that are thought to have the potential as antibacterial namely flavonoids, phenols and terpenoids. The objective of this study was to find effective drugs formulated from Melastoma malabathricum leaves combined with antibiotics as diabetic foot ulcer therapy to prevent further complications and risk of disability in diabetes mellitus patients. Ciprofloxacin and gentamicin were proven to be resistant antibiotics. In this study, the fraction of Melastoma malabathricum leaves was combined with both types of antibiotics namely ciprofloxacin and gentamicin. The minimum inhibitory concentration (MIC) has been determined against bacterial strains. The determination of MIC (Minimum Inhibitory Concentration) value was done using the Kirby-Bauer disk diffusion method. The interaction of antibiotics with gentamicin and ciprofloxacin was studied in vitro by calculating fractional inhibitory concentration index (FICI). The synergistic effects of the combination Melastoma malabathricum fraction and antibiotics were observed. The results showed that the combination of Melastoma malabathricum fraction with ciprofloxacin and the combination of Melastoma malabathricum fraction with gentamicin against Escherichia coli had a synergistic effect with FICI value of 0,5. The combination of Melastoma malabathricum fraction with ciprofloxacin and the combination of Melastoma malabathricum fraction with gentamicin have the synergistic effect inhibiting the Escherichia coli.
In Silico Study on the Effect of Heliannuol A, B, C, D, E Compounds of Sunflower (Helianthus annuus L.) on Dual PI3K/mTOR (5OQ4) Enzyme
Authors: Mutiah Roihatul , Indrawijaya Yen Yen Ari , Dharma Tanaya Jati , Damaiyanti Jamilah
Published: March 2022

Heliannuol is a sesquiterpene that has a benzoxepine ring, oxepin. Many derivatives of benzoxepine compounds show anticancer activity by inhibiting the phosphoinositide 3-kinase (PI3K) enzyme. These enzymes play a role in cell proliferation and growth. The study aims to predict the physicochemical properties using Lipinski’s Rule of Five parameters on phosphoinositide 3- kinase (PI3K/Mtor; PDB 5OQ4) enzyme and the toxicity of Heliannuol A, B, C, D, E compounds. The process uses the pkCSM online tool. The validation of receptor 5OQ4 is done using the value parameter RMSD < 2 (Å). Protox online tool dan pkCSM online tool is employed to predict the toxicity using parameter LD50, skin sensitization, Ames toxicity, hepatotoxicity, and toxicity class. The interaction of ligan and enzyme is tested using Molegro Virtual Docker 6.0. Heliannoul A, B, C, D, E compounds fulfill Lipinski’s Rule of Five. The receptor 5OQ4 is known valid using the value of RMSD 0,923 (Å). Heliannuol A, B, C, D, E compounds inhibit Dual PI3K / mTOR enzyme less than Bimiralisib. As a result of the toxicity test of compounds Helliannouls A, B, C, E, and Bimiralisib compounds are included in class 4, while Helliannouls D compounds are included in class 5.