bluuebunny/crossref_metadata_2025 huggingface dataset:
Infecção por HPV e Controle do Câncer no Brasil: O Importante Papel da Vacinação
Authors: Reis Rejane de Souza , Lima Fernanda Cristina da Silva de , Silva Darlan Henrique Nascimento da , Cavalcante Juan Pablo Ferreira , Corrêa Flávia de Miranda , Santos Yammê Ramos Portella , Scaff Alfredo José Monteiro
Published: February 2025

Introdução: A vacinação contra o papilomavírus humano (HPV) é crucial para o controle do câncer no Brasil. Apesar dos esforços, o país ainda não atingiu as metas globais projetadas para 2030 que podem levar à erradicação do câncer do colo do útero após 2050. Objetivo: Descrever a cobertura vacinal contra o HPV, analisar a morbidade hospitalar, além da tendência da mortalidade dos cânceres associados a esse vírus no Brasil. Método: Foram analisadas as informações sobre a cobertura vacinal contra o HPV no Brasil, a morbidade hospitalar e a mortalidade de alguns tipos de cânceres que são relacionados ao HPV, a saber: colo do útero, vulva, vagina, orofaringe, ânus e pênis. Resultados: A cobertura vacinal contra o HPV na primeira dose nas meninas, de 2013-2021, foi de 76% e nos meninos, de 2017-2021, de 52%. O Estado do Acre apresenta a menor cobertura vacinal. Foram analisados 260.784 pacientes, no período de 2006-2020. Mais de 80% dos pacientes com câncer de orofaringe têm seus diagnósticos feitos em estádios avançados. O câncer de ânus e canal anal apresentou um aumento na mortalidade em média de 7,1% ao ano entre os homens e 4,4% ao ano entre as mulheres. Conclusão: A vacinação contra o HPV é fundamental e vai além da prevenção para o câncer do colo do útero. A cobertura vacinal no Brasil ainda é insuficiente, o que reforça a necessidade de ações integradas e eficazes para reduzir a morbidade e mortalidade dos cânceres relacionados ao HPV.
Round window sealing with steroid-soaked sponge in sudden sensorineural hearing loss
Authors: Putranto Fikri Mirza , Safitri Eka Dian , Shafira Ardys
Published: February 2025

Background: A rescue treatment is needed in cases of Sudden Sensorineural Hearing Loss (SSNHL)which fail to obtain complete hearing restoration after conservative steroid therapy. In order to acquirebetter access of steroid to the cochlea, sealing the round window with a sponge soaked in steroid couldbe considered as an alternative delivery strategy.
Purpose: To review the evidence about the impact ofround window sealing in SSNHL patients whose hearing failed to recover completely after treated withsystemic and/or intratympanic steroid.
Cases: Seven patients with SSNHL, who had experienced either noor slight response to previous systemic and/or intratympanic steroid administration, underwent transcanalround window sealing with steroid-soaked sponge. Pure Tone Audiometry (PTA) results and symptoms(hearing loss, tinnitus, vertigo) were compared pre- and post-operatively. Five patients reported betterhearing and tinnitus symptom.
Method: A scoping review was made by conducting literature searchingat Cochrane, Pubmed, and Google Scholar using keywords “sudden sensorineural hearing loss”, AND“round window sealing”, and their relevant synonymous terms, employing Boolean operators.
Result: Atotal of 8 observational studies with 430 subjects met the inclusion criteria. Time measurement of hearingimprovement range from 6 days until 1 year. Most of the studies agreed that the procedure of sealingthe round window had a positive impact on hearing improvement.
Conclusion: This study revealed thatround window sealing with steroid-soaked sponged could be considered as an alternative approach forpatients with SSNHL who failed in conservative therapy.
 
Keywords: “round window sealing; sudden sensorineural hearing loss; transtympanic steroid”
Effect of N-Acetylcysteine and vitamin D supplementation on interleukin-1β level in chronic suppurative otitis media
Authors: Dewi Pratiwi , Gayatri Astrid
Published: February 2025

Background: Chronic suppurative otitis media (CSOM) is a major health problem in many populations around the world, causing significant morbidity and mortality. It is characterized by transformation and hyperplasia of the middle ear mucosa following infiltration of numerous inflammatory cells. Recent researches showed a significant impact of the anti-inflammatory and anti-oxidant effects of N-Acetylcysteine (NAC) and vitamin D independently, but their role in the pathophysiology of CSOM was still unclear. Purpose: To evaluate the effect of NAC and vitamin D supplementation on vitamin D and interleukine-1β levels in CSOM. Method: The research was an experimental study with randomized controlled trial design, and was conducted at ENT polyclinic, Dr Moewardi Regional General Hospital Surakarta on May-October 2023. Blood serum examination of vitamin D and IL-1β levels was done at Biomedical Laboratory of Medical Faculty Sebelas Maret University. Result: There were 36 CSOM subjects without cholesteatoma who met the inclusion and exclusion criteria. The NAC+vitamin D group had the highest mean vitamin D level (30.82±5.35 ng/mL) and the lowest mean IL-1β level (23.81±7.13 pg/mL) compared to the control group and the group that received only NAC or vitamin D alone. (p<0.05). Conclusion: N-Acetylcysteine and vitamin D supplementation had a synergistic effect in reducing oxidative stress and inflammation in CSOM.
In vitro activity of Manuka and Trigona honey on fibroblast and keratinocyte cultures
Authors: Priyono Harim , Restuti Ratna Dwi , Kusuma Indra , Harahap Alida , Ascobat Purwantyastuti , Setiabudy Rianto , Sulaeman Ahmad , Lasminingrum Lina , Putri Pingkan Permata , Hidayati Anggi Puspa Nur
Published: February 2025

Background: Benefits of honey on wound healing is widely reported, but information about itseffect on the re-epithelialization of the tympanic membrane (TM) is limited. Purpose: To evaluate theeffect of Manuka honey (MHn) and Trigona honey (THn) from Indonesia, on TM re-epithelializationthrough their potential action on proliferation of fibroblasts, keratinocytes, secretion of KFG and basic-FGF. Method: This study was conducted at the YARSI University Laboratory. Fibroblast and keratinocyte cultures isolated from chronic suppurative otitis media patients were exposed to MHn and THn with three dilutions: 0.04%, 0.1%, and 0.25%. The cells were then subjected to proliferation assays, KGF and bFGF were also assessed and compared to the control. Result: MHn and THn did not increase the number of fibroblasts but shortened the doubling time duration. A significantly higher number of keratinocytes than control was observed in all MH groups and the 0.04% THn group. KGF secretion increased as the number of cells increased. On the 6th and 8th day, KGF secretion was observed to be higher in some intervention groups compared to the control group. Conversely, the level of bFGF secreted by fibroblasts and keratinocytes decreased as the number of cells increased. There was a positive correlation between the duration of both honey exposure and fibroblast proliferation. The duration of 0.04%, 0.1% MHn, and 0.04% THn exposure positively correlated with the number of keratinocytes. Conclusion: This research illustrated the positive effects of MHn and THn on fibroblasts and keratinocytes; thus, potential therapeutic properties could be further explored.
Analysis of the Influence of the Quality of Dental and Oral Health Service on the Level of Patient Satisfaction at RSI Malahayati Medan
Authors: Japardi Angely , Theo Deli , Amira Asriwati
Published: February 2025

Background: The quality of health services can affect the degree of hhealth and well- being of patients, because satisfied patients will come for treatment again. The purpose of this study is to analyze the effect of dental and oral health services on patient satisfaction at the Malahayati Islamic Hospital. Methodology: This research uses a quantitative analytic survey research with cross sectional study design. The location of this study was conducted at the Malahayati Islamic Hospital. The study population was all out patients who visited with Total Visit on May 2023-August 2023 of 422 patients. The number of samples in this study were 81 people. The technique used is purposive sampling. Survey data were analyzed using the chi-square test and logistic regression. Results: The results showed that there was an effect of tangibility, reliability, responsiveness, assurance and empathy for dental and oral health services on patient satisfaction. Conclusion: Based on the results of the study note that tangible, reliability, responsiveness, assurance and empathy affect patient satisfaction at the MalahayatiPublic Health Center in Medan and the variables that most influence on patient satisfaction are responsiveness variables. The suggestion for this research is that the Hospital should maintain customer satisfaction by increasing the quality of service and completing the infrastructure that is still lacking so that patient satisfaction is fulfilled and patients become loyal.
Description of Dengue Hemorrhagic Fever Cases in Health Centers in the East Pekalongan Sub-District in 2023
Authors: Irawan Teguh , Indriyani Yulis , Angraeni Diva Alya , Amalia Putri Rika , Zahro Fatimata , Mutiafani Amelia , Yusuf Muhammad Lutfi
Published: February 2025

In terms of public health, Dengue Hemorrhagic Fever (DHF) is a problem in Indonesia. The Aedes aegypti mosquito infected with dengue virus is the vector of dengue hemorrhagic fever (DHF).  DHF is usually found in tropical climates, as vector characteristics are influenced by rainfall, temperature, and rapid movement. Data shows that Asia is the center of the most cases of dengue fever every year, and Indonesia is still one of the main transmission areas. In 2017, the dengue incidence rate in Pekalongan City was 1.44 cases per 10,000 population, and there were 44 confirmed cases in the Pekalongan City Health Center area, consisting of 18 males and 16 females. Therefore, this study aims to describe dengue hemorrhagic fever (DHF) cases at the health center in the east Pekalongan sub-district area in 2023, including the number of cases, age, gender, and time of occurrence of cases. This study uses a descriptive method in which secondary data on DHF patients recorded at the Noyontaan, Tondano, and Sukorejo health centers are obtained and then analyzed descriptively using the SPSS version 24 application. Based on the results of the research, the number of DHF cases at the Puskesmas of East Pekalongan Subdistrict in 2023 was quite high, as many as 49 cases, with the highest number of DHF cases found in the Tondano health center area. The number of DHF patients occurred in the adolescent age group of 10-18 years as many as 20 cases (40.8%) and 25 cases (51.0%) of males. The high number of DHF cases indicates the need for more intensive disease prevention and control efforts, especially in the adolescent age group, as well as paying attention to the increase in cases in certain months.
Factors Influencing the Incidence of Abortion at Imelda Pekerja Indonesia General Hospital in 2023
Authors: Winda Isra Nur , Nadapdap Thomson P. , Fitria Aida
Published: February 2025

Incidence of Abortion at Imelda Pekerja Indonesia General Hospital in 2022 increased by 95 abortion cases (56.5%) out of 168 pregnancies. The incidence of abortion remains high due to the prevalence of abortion among working mothers. The purpose of this study is to analyze the factors influencing the incidence of abortion at Imelda Pekerja Indonesia General Hospital in 2023. The research employs a mixed-methods approach with sequential explanatory design. The quantitative sample consists of 50 pregnant women who experienced abortions, using medical record data and total sampling method. The qualitative research involves 10 informants selected through purposive sampling. Quantitative data analysis includes univariate, bivariate, and multivariate analysis using Chi-Square and Multiple Linear Regression tests. Qualitative data analysis involves data reduction, data presentation, and conclusion drawing. Based on the Chi-Square test results, variables with a p- value < 0.05 indicate a significant relationship between age, parity, pregnancy interval, history of abortion, education level, occupation, and maternal disease history with the incidence of abortion. The Multiple Linear Regression test reveals that the most influential factor is the history of abortion, particularly incomplete abortion. Qualitative research results also show the influence of age, parity, pregnancy interval, history of abortion, education level, occupation, and maternal disease history on the incidence of abortion, with the most influential variable being the history of abortion, specifically incomplete abortion. The conclusion of this study is that there is a significant relationship between age, parity, pregnancy interval, history of abortion, education level, occupation, and maternal disease history with the incidence of abortion at Imelda Pekerja Indonesia General Hospital in 2023, with the most influential variable being the history of abortion, particularly incomplete abortion. It is recommended that healthcare providers offer information about abortion to pregnant women, those who have experienced abortion, and those with a history of abortion, and encourage pregnant women to regularly undergo prenatal check-ups.
Maya Angelou's I Know Why the Caged Bird Sings: The Journey to Freedom and Empowerment
Authors: Arwa A. Khayat  , Dawla S. Alamri
Published: February 2025

Maya Angelou's memoir, I Know Why the Caged Bird Sings (1969), demonstrates the transformative power of resistance and the complexities of being a Black woman in a racially oppressive society. This paper delves into Angelou's narrative, examining how she portrays the complexities and intersections of race and gender and their impact on Black women’s lives.  The study also explores the various forms of resistance employed by Angelou and other Black women depicted in the memoir through the Black feminist perspectives of Patricia Hill Collins.  This perspective provides a lens through which to thoroughly examine the themes of racism, sexism, identity, and resilience central to Angelou's work. Collins’ perspectives offer a critical and intersectional analysis of Black women's unique perspectives, experiences, and struggles. This study argues that Angelou's acts of defiance, ranging from self-expression through literature and poetry to the pursuit of education and the strength found in the community, lead to personal growth, empowerment, and liberation. The findings of this research highlight Angelou’s self-determination, acts of defiance and resistance, self-expression, and collective solidarity in the ongoing struggle against intersectional oppression and the impact on her journey of empowerment, self-healing, and liberation to become a voice that supports others’ freedom.
The Qualities of a Righteous Wife in Islamic Law
Authors: Mohammad Amin Ahmadi  , Mirabdulqadir Hashimi
Published: February 2025

This research presents an in-depth study on the qualities of a righteous wife in Islamic jurisprudence, which are considered important foundations for ensuring family stability and happiness, and strengthening the bonds between spouses. The research problem was identified in the extent of the importance of the wife's commitment to these qualities according to Islamic law to achieve marital happiness. The research aims to identify and clarify the qualities that a righteous wife should possess, such as obedience in what is known, keeping money and secrets, good morals and manners, and the skill of raising children. The research relied on the descriptive analytical approach by reviewing the legal texts in the Holy Quran and the Sunnah of the Prophet, and analyzing the opinions of jurists from the four schools of thought to highlight the importance of these qualities. The results showed that the aforementioned qualities play a fundamental role in achieving psychological and social security within the family, and contribute to building a relationship based on mutual respect and trust, and are also a major factor in preparing a cohesive generation that carries Islamic values. The research concluded that the qualities of a good wife according to Islamic jurisprudence are not merely moral qualities, but are necessary criteria for establishing a stable marital life and a cohesive society. Thus, the importance of enhancing these qualities in wives to achieve the objectives of marriage in Islam of affection, mercy, and stability is highlighted.
Writing in English and Writing in Standard Arabic in Higher Education: A Correlational Study
Authors: Mahmoud Belmekki  , Lahcen Belmekki  , Mustapha Chihab  , Bani Koumachi  , Mohamed Benmhamed
Published: February 2025

Writing as a mental and cognitive process entails bringing into light students’ written products. Writing in higher education is considered one of the most important skills that students should develop. In this regard, this study investigates the correlation between writing in Standard Arabic and writing in English among university students in Morocco. To verify this link, two tests were used as research instruments. Students were asked to write a paragraph in Standard Arabic and another in English. The participants were 33 male and female university students. To analyse the scores that students obtained in the two tests, a Pearson Product Moment correlation was used as a statistical procedure. The results indicate that there is a significant correlation between writing in Standard Arabic and writing in English. The students who performed well in Standard Arabic also did well in writing in English. It has also been found that there is a 21.20% relationship between the two variables under examination. The findings of this study support the Chomskyan Universal Grammar perspective. It also supports the notion of positive transfer. The results of this study have different implications for language teaching and learning.
Analysis of Speech Act Performance in Four Khmer-Language Online Newspapers: Content related to Coronavirus or Covid-19 pandemics
Authors: Suon Sotheara , Bunlot Khoy  , Bophan Khan  , Matthew Piscioneri
Published: February 2025

This paper reports on research conducted to identify the speech act performances in articles in four Khmer-language online newspapers covering the Coronavirus or Covid-19 pandemic in Cambodia. John Searle's (1975) speech act theory has been adopted as the primary framework for categorizing speech act performances. Two datasets were collected approximately six months apart (23-29, 2020 January and 23-29 July 2020). Overall, the most frequent type of illocutionary speech act in both the headlines and the body text of the articles was the assertives. Notably, an increasing frequency of directives type speech acts was discerned in the later dataset (July 2020) in the body text of the articles especially. The study, we believe, further highlights the potential usefulness of the application of Searle's speech act framework in analyzing public health media content and accords well with relevant earlier findings established by Al-Hidawi & Ali (2018) and Qomariyah (2019).
Donald Trump's Satirical Remarks toward Joe Biden and Kamala Harris during the 2024 Presidential Debates: A Critical Discourse Analysis (CDA)
Authors: Altamimi Aleen
Published: February 2025

This study investigates the satirical remarks uttered by President Donald Trump towards former President Joe Biden and former Vice President Kamala Harris during the 2024 Presidential election utilizing Critical Discourse Analysis (CDA), applying Norman Fairclough’s three-dimensional model. The study addresses two essential questions: (1) What are the hidden implications of President Trump’s remarks toward former President Biden and former Vice President Harris? and (2) How do these remarks contribute to weakening the public image of Biden and Harris? A qualitative analysis of Trump's language reveals that satire played a crucial role in Trump’s discourse, with repeated mockery as a strategic instrument to undermine the political image of the opponents. The analysis shows how Trump’s satirical remarks shaped public views, effectively deteriorating the credibility of Biden and Harris as perceived by their advocates and potential voters. The study addresses the implications for future investigation, encouraging a more nuanced exploration of the linguistic strategies utilized by Biden and Harris as a counter to Trump's discourse. Future studies could benefit from incorporating alternative theoretical frameworks, such as Foucault’s views on discourse and power, to expand the comprehension of political language in presidential campaigns.
Cannabidiol (cbd): generalidades farmacológicas, terapéuticas y potencialidad en el trastorno por consumo de sustancias
Authors:   Universidad de Cartagena, Marimón Javier David , Pastrana Arias (doncente) Ariel Enrique
Published: February 2025

Tratamientos farmacológicos disponibles para el manejo de los trastornos por uso de sustancias presentes múltiples limitaciones en la eficacia, falta de tratamientos aprobados o tasas de recaída alarmantes. Estos hechos dificultan el resultado clínico y la calidad de vida de los pacientes apoyando la importancia para el desarrollo de nuevos agentes farmacológicos. Últimamente, varios informes sugieren que cannabidiol (CBD) presenta efectos benéficos relevantes para el manejo de enfermedades neurológicas trastornos como la epilepsia, la esclerosis múltiple, el Parkinson o las enfermedades de Alzheimer. Además, existe una gran cantidad de evidencia que señala que el CBD mejora cognición, neurogénesis y presenta ansiolíticos, antidepresivos, antipsicóticos y efectos neuroprotectores que sugieren una utilidad potencial para el tratamiento de enfermedades neuropsiquiátricas y TUS. Aquí reviso informes preclínicos y clínicos en cuanto a los efectos del CBD en la regulación del refuerzo, motivación y efectos relacionados con la abstinencia de diferentes drogas de abuso, como el alcohol, los opioides (morfina, heroína), cannabinoides, nicotina y psicoestimulantes (cocaína, anfetamina).
PENGEMBANGAN USAHA BUDIDAYA KEPITING DALAM KAWASAN HUTAN MANGROVE MELALUI SISTEM SILVOFISHERY YANG BERBASIS MASYARAKAT
Authors: Rustam Rustam , Hartinah Hartinah
Published: February 2025

The purpose of this community partnership empowerment (PKM) activity is 1) to provideknowledge and skills to fishermen groups about enlarging crab crabs with silvofishery systems; 2)optimally and sustainably utilizing mangrove forest resources; and 3) increase added value andemployment opportunities for coastal communities. The method of activity includes: 1)socialization and demonstration; 2) monitoring and evaluation includes the initial, mid and finalstages of program implementation. The targets and outcomes of the community partnershipempowerment (PKM) activities are 1) creating alternative livelihoods for the people in the coastalareas, especially around the mangrove forest area through an effort to enlarge crabs so that theirincome can increase; 2) carry out mangrove forest conservation through mangrove forests withcultivation technology using cages or silvofishery systems; 3) forming community business unitsthat implement good production management and business management systems; and 4) maintaincontinuity of production and fulfill market needs for crab crabs.An understanding of mangroves and the cultivation of crabs with silvofishery systems in learningfor the community as outlined in the training and practice activities is well understood to carry outthese activities.
Описание эффекта перекрестного упрочнения в рамках структурно-имитационной модели деформирования сплавов с памятью формы
Authors:   ФГБУН Институт прикладной механики РАН, г. Москва, Россия, Мовчан А.А. , Рихмайер А.М. ,   Московский государственный университет им. М.В. Ломоносова, г. Москва, Россия
Published: February 2025

Для сплавов с памятью формы характерен эффект перекрестного упрочнения, сводящийся к тому, что упрочнить образец из этого материала в отношении деформирования в режиме мартенситной неупругости (структурный механизм, не меняющий тип кристаллической ячейки, а лишь увеличивающий степень ориентированности содержащихся в представительном объеме материала низкосимметричных мартенситных кристаллических ячеек) можно путем прямого термоупругого мартенситного превращения под действием постоянного напряжения, при котором тип кристаллической ячейки меняется от высокосимметричной аустенитной до низкосимметричной мартенситной, а степень ориентированности получающихся мартенситных ячеек представительного объема фиксирована. При этом, согласно экспериментальным данным, напряжение начала действия структурного механизма на этапе деформирования в режиме мартенситной неупругости может существенно превышать то напряжение, под действием которого происходил процесс накопления деформаций на предварительном этапе полного прямого превращения. Разницу между этими двумя напряжениями можно считать количественной характеристикой эффекта перекрестного упрочнения. Работа посвящена выяснению вопроса о том, какие свойства процессов, происходящих на различных структурных уровнях в сплавах с памятью формы, обеспечивают наличие эффекта перекрестного упрочнения. Для решения этой проблемы используется структурно-имитационная модель деформирования сплавов с памятью формы, непосредственно апеллирующая к процессам зарождения и развития мартенситных мезоэлементов при прямом термоупругом фазовом превращении и их деградации и исчезновении при обратном превращении, их доориентации или переориентации при структурном переходе. С помощью этой модели ранее аналогичные проблемы были решены для эффектов накопления деформаций прямого превращения, явления ориентированного превращения, монотонной и реверсивной памяти формы, эффекта мартенситной неупругости.
فاعلية برنامج تدريبي لتحسين مهارات الإدراك لدي أطفال الروضة
Authors: البروفيسور منصور بانقا  حجر محمد  , الدكتور عبد الحميد حسن حاج أمين
Published: February 2025

هدفت الدراسة  إلى التعرف على فاعلية برنامج تدريبي في تحسين مهارات الإدراك لدي أطفال الروضة, ومعرفة الفروق ذات الدلالة الإحصائية بين إجابات الأطفال، قبل تطبيق البرنامج التدريبي وبعد تطبيقه, ومعرفة الفروق ذات الدلالة الإحصائية بين إجابات الأطفال, ترجع لمتغيرات الدارسة النوع, المستوي, مستوي تعليم ولي أمر الطفل, استخدمت الدراسة المنهج  شبه التجريبي, والبرنامج التدريبي والمقياس أدوات لها  تمثل  مجتمع الدراسة في أطفال روضات حي الملك بلدية القضارف، واتخذت الدراسة  عينة قصدية تمثلت في أطفال روضة ماما صفية والبالغ عددهم (31) طفل, وتم تحليل النتائج بواسطة برنامج الحزم الإحصائية للعلوم الاجتماع     (spss) وتوصلت الدراسة إلي أنه توجد فروق ذات دلالة إحصائية بين إجابات  الأطفال قبل تطبيق البرنامج التدريبي وبعد تطبيقه, لصالح إجابات أطفال الروضة بعد تطبيق البرنامج, كما أنه توجد فروق ذات دلالة إحصائية بين إجابات أطفال الروضة قبل تطبيق البرنامج التدريبي وبعد تطبيقه, لصالح إجابات أطفال الروضة بالمستوي الثاني, كما أنه توجد فروق ذات دلالة إحصائية بين إجابات أطفال الروضة قبل تطبيق البرنامج التدريبي وبعد تطبيقه ترجع لمستوي تعليم ولي أمر الطفل, لصالح المستوي الجامعي لولي الأمر,  و لا توجد فروق ذات دلالة إحصائية بين المتوسطات بين إجابات أطفال الروضة بعد تطبيق البرنامج  ترجع لنوع الطفل.
التعلم المصغر القائم على محفزات الألعاب وأثره على تنمية الدافعية للإنجاز لدى طلاب جامعة جدة
Authors: د. وليد يسري عبد الحي الرفاعي  , أ.د. وليد سالم محمد الحلفاوي  , د. مروة زكي توفيق زكي  , د. فاطمة محمد عبد الباقي أبو شنادي  , د. غادة إبراهيم محمد أبوشادي
Published: February 2025

مع التوجه العالمي للاستفادة من التطورات التقنية لتحسين بيئات التعلم وزيادة فاعليتها، تبرز الحاجة إلى أساليب مبتكرة تعزز أداء الطلاب وتزوّدهم بالمعارف والمهارات المطلوبة لمواكبة سوق العمل المتغير. وتعتبر نظم وبرامج التعلم المصغر ومحفزات الألعاب التعليمية من الحلول التقنية الواعدة التي تتطلب مزيدًا من البحث والدراسة لدعم تحقيق أهداف التعلم بفعالية وكفاءة؛عليه فقد استهدف البحث الحالي قياس أثر التعلم المصغر القائم على محفزات الألعاب التعليمية على تنمية الدافعية للإنجاز لدى طلاب جامعة جدة. اعتمد البحث على المنهج التجريبي والتصميم شبه التجريبي ذي المجموعتين التجريبيتين مع القياس القبلي والبعدي، طُبق البحث على عينة من (60) طالبًا خلال الفصل الدراسي الأول لعام 2022/2023، تم توزيعهم عشوائيًا بالتساوي على مجموعتين تجريبيتين: الأولى (30 طالبًا) للتعلم من خلال التعلم المصغر، والثانية (30 طالبًا) للتعلم من خلال التعلم المصغر القائم على محفزات الألعاب، وتمثلت أدوات البحث في مقياس الدافعية للإنجاز. واعتمد البحث في تحليل النتائج على اختبار (ت) للوقوف على دلالة الفروق بين المجموعتين التجريبيتين، ومربع إيتا لقياس حجم الأثر. أظهرت نتائج البحث أن التعلم المصغر القائم على محفزات الألعاب كان له تأثير أكبر في تعزيز الدافعية للإنجاز لدى الطلاب مقارنةً بالتعلم المصغر التقليدي؛ استنادًا إلى نتائج البحث، قدم الباحثون مجموعة من التوصيات والمقترحات تؤكد على أهمية تبني استراتيجية التعلم المصغر القائم على محفزات الألعاب كأداة فعالة لتعزيز الدافعية وتحفيز المتعلمين، وزيادة فعالية العملية التعليمية وتحسين نواتجها، مع التوسع في تطبيق هذه الاستراتيجية في مجالات تعليمية مختلفة لتحقيق تحسينات ملموسة في مستوى التفاعل والأداء التعليمي.
Interações entre anti-hipertensivos e antidiabéticos: Avaliação de riscos e impacto na saúde do paciente
Authors: Aguiar Anyele Pereira de , Salusto Victória Marinna Honorato , Cavalcante Giani Maria
Published: February 2025

Interação medicamentosa consiste na modificação, aumento ou diminuição do efeito de um fármaco diante de sua administração concomitante com outro fármaco, o que gera um desfecho distinto daquele onde se administra apenas um dos fármacos. O objetivo deste trabalho foi investigar as potenciais interações entre os medicamentos utilizados no tratamento do diabetes mellitus concomitante ao tratamento da hipertensão arterial a partir da literatura. Neste estudo foi realizado uma revisão da literatura, com busca aprofundada em diversos bancos de dados eletrônicos LILASC, SCIELO e PUBMED considerando as publicações entre os anos de 2014 a 2024. O estudo foi realizado com o uso de palavras que se relacionam com o tema abordado, com os descritores “Interações medicamentosas”, “Drug interactions”, “Interações entre anti-hipertensivos e antidiabéticos”, “Antihypertensives and antidiabetics”. Após análise de 10 artigos, foram encontradas as principais interações dos seguintes fármacos, Atenolol, Captopril, Espironolactona, Furosemida, Gliclazida, Glibenclamida, Hidroclorotiazida, Insulina, Losartana, Metformina, Succinato de Metoprolol e Valsartana. Algumas interações mostram possíveis complicações como descontrole glicêmico e de pressão arterial, podendo levar também a insuficiência renal. O uso concomitante de medicamentos para diabetes e hipertensão exige cuidado e atenção dos profissionais de saúde, a fim de evitar possíveis complicações para os pacientes.
Forame Oval Patente: Risco de Acidente Vascular Cerebral isquêmico e formas de como obter o diagnóstico
Authors: Vilela Melissa Miranda , Meneguetti Rafaela , Mainardes Sandra Cristina Catelan
Published: February 2025

O Acidente Vascular Cerebral Isquêmico (AVCi) está entre as principais causas de mortes do mundo. Recentemente, estudos têm relacionado o AVCi com o Forame Oval Patente (FOP), por essa relação ser comum em pacientes jovens e sem fatores de risco. O forame oval é encontrado na vida intrauterina, com o nascimento e início da respiração, o mesmo fecha-se fisiologicamente. O não fechamento possibilita a passagem de êmbolos do sistema venoso para o arterial pelo shunt direito-esquerdo, dessa forma podendo interromper a irrigação cerebral e diminuindo as taxas de oxigênio, o que caracteriza o AVCi O estudo tem como objetivo descrever a relação entre forame oval patente e acidente vascular encefálico isquêmico. Assim, esta pesquisa baseou-se em uma análise de artigos selecionados das bases de dados BVS, PubMED, e Scielo, publicados entre 2019 e 2024. A pesquisa inicial do estudo resultou em 163 achados, havendo exclusão de 138 por motivos como: duplicidade, não serem do idioma adequado ou por não responderem à pergunta norteadora. Sendo assim, 25 trabalhos foram selecionados para a produção do estudo. A partir dos achados, foram reunidos o conjunto de elementos e foram organizados segundo o critério PRISMA, produzindo uma revisão integrativa baseada na pergunta norteadora. A pesquisa possibilitou estabelecer o vínculo entre o FOP e o AVCi e entender sobre as possíveis formas de diagnóstico. Bem como compreender sobre a anatomia e formas de tratamento para evitar AVCi em pacientes com FOP, trazendo menos riscos à saúde da população.
Prevalência da Tuberculose no Brasil: Um estudo epidemiológico
Authors: Prata Ian Hirt , Madureira Eduardo Miguel Prata , Klein Leonardo Godoy , Silva Luiza Morandini Gaspar da
Published: February 2025

A Tuberculose (TB) é uma infecção causada pelo Mycobacterium tuberculosis, um bacilo transmitido predominantemente por aerossóis, que tem causado impacto negativo na saúde humana desde os primórdios da humanidade. Essa doença está diretamente associada a fatores socioeconômicos, como pobreza, desnutrição, superlotação e condições de imunossupressão, sendo um reflexo das desigualdades sociais. Desde que Robert Koch descobriu a natureza sua natureza infecciosa, em 1882, a tuberculose tornou-se alvo de estudos aprofundados que proporcionaram avanços significativos na compreensão de sua história natural e fisiopatologia. Apesar disso, a tuberculose continua sendo um desafio persistente para a saúde pública global, especialmente em países em desenvolvimento. O tratamento, acessível de baixo custo, pode ser eficaz, mas a interrupção e abandono do mesmo resulta em complicações graves. Metodologia: Este estudo analisou a prevalência de casos de tuberculose nas cinco regiões do Brasil entre 2013 e 2023. Os dados utilizados foram obtidos no Departamento de Informática do Sistema Único de Saúde (DATASUS), considerando variações regionais e seus impactos na saúde pública. Objetivo: O principal objetivo é propor melhorias na assistência aos casos de tuberculose, considerando as especificidades de cada região brasileira, bem como a necessidade de politicas públicas mais eficazes.Resultado: Durante o período avaliado, todas as regiões brasileiras apresentaram aumento nos casos tuberculose. As taxas dele crescimento foram: Norte 59%, o Nordeste 24%, Sudeste 29%, Sul 19% e Centro-Oeste 28%, demonstrando a necessidade de estratégias regionais específicas e investimentos contínuos na saúde pública.
Fatores associados à prevalência de tumores mamários em cadelas e suas implicações no prognóstico pós-quimioterapia
Authors: Souza Aline Bittencourt de , Silva Lizane Paula de Farias e , Santiago Marilene Felipe , Silva Marcos Henrique da , Farias Maria Clara Lavrador , Procópio Débora Lopes , Duarte Douglas Sabino Leite de Oliveira , Waterloo Mateus de Melo Lima
Published: February 2025

Os tumores mamários em cadelas são uma das neoplasias mais frequentes nessa espécie, sendo influenciados por fatores hormonais e ambientais. O objetivo deste estudo é analisar os aspectos clínicos, diagnósticos e terapêuticos dos tumores mamários em cadelas. A metodologia utilizada consistiu na pesquisa de artigos científicos em bases de dados como Google Scholar, PubMed e Scielo, utilizando termos ligados a tumores mamários, neoplasias e cães. Os achados sugerem que a enfermidade geralmente se manifesta em cães idosos, com a presença mais frequente de nódulos mamários, com potencial maligno em mais de 50% das situações. O diagnóstico é fundamentado em análises clínicas, citológicas e histopatológicas para estabelecer a natureza do tumor e o seu prognóstico. A terapia envolve a eliminação cirúrgica do tumor, que pode envolver mastectomia total ou parcial, associada ou não a terapias complementares, como a quimioterapia. A castração precoce é vista como uma estratégia de prevenção eficiente. Mesmo com a seriedade de casos malignos, o prognóstico pode ser promissor, contanto que o diagnóstico e o tratamento sejam precoces. É essencial que os tutores estejam atentos aos sinais clínicos e mantenham acompanhamento veterinário regular. Esta pesquisa conclui que o manejo adequado e o tratamento precoce podem melhorar significativamente a qualidade de vida das cadelas acometidas.
Transformações do uso e cobertura do solo na Bacia Hidrográfica do Alto Juruá – Acre por meio da plataforma MapBiomas
Authors: Santos Talita Santana dos , Santos Neto José Epitácio dos , Souza Emanuel Moraes de , José Jefferson Vieira , Leite Kelly Nascimento , Valadão Marco Bruno Xavier
Published: February 2025

A ação antrópica em ambientes florestais, principalmente para a formação de áreas agricultáveis provoca impactos ambientais em bacias hidrográficas. Dessa maneira, o objetivo desta pesquisa foi estudar o uso e ocupação do solo da bacia hidrográfica do Alto Juruá localizado no Estado do Acre, em um intervalo de 36 anos (1985-2020), com o intuito de identificar em qual período houve tiveram maior ocorrência da ação antrópica na paisagem. Foi utilizado os dados da plataforma MapBiomas, versão 3.0, com auxílio do Google Earth Engine. Os resultados indicaram que a agricultura apresentou maior atuação no período estudado e que em 2020 esse agente representou 4,8% da área total da bacia. A classe da pastagem não apresentou aumento, contribuindo com 0,26% em 2018. A classe formação florestal, com 94%, indicou que a bacia possui grande área de florestada. Por último a classe de infraestrutura urbana foi igual a 0,1%. Conclui-se que a bacia hidrográfica do Alto Juruá, apresentou certo grau de perturbação principalmente em função da agricultura em detrimento de outras classes como a pastagem.
Comunicação interatrial e hipertensão pulmonar em paciente hematológica
Authors: Gon Renata Peixoto Abrão , Santos Vitória Rossetti Moreira dos , Lemes Dara Ramires , Stradiotto Diogo
Published: February 2025

A Comunicação Interatrial (CIA) é uma má formação congênita classificada em quatro tipos: ostium secundum, ostium primum, seio venoso e seio coronário, sendo o primeiro o mais prevalente e o foco desta investigação. O diagnóstico desta condição é de fundamental importância devido às suas potenciais complicações, que podem ser agravadas quando associadas a outras comorbidades como anemia falciforme e leucemia mieloide crônica (LMC) que merecem consideração especial, principalmente se o tratamento envolver agentes cardiotóxicos. O objetivo deste estudo descritivo é salientar a complexidade da abordagem clínica das cardiopatias congênitas e das doenças hematológicas por meio de um relato de caso acompanhado de uma revisão literária pertinente. Baseando-se na análise de um caso singular, utilizando dados obtidos do prontuário eletrônico, o relato destaca uma paciente do sexo feminino, 57 anos, de etnia branca, casada e com ocupação doméstica, que busca assistência médica devido à sintomatologia de dispneia pós-exercício e fadiga persistente. A paciente estava em tratamento de segunda linha para leucemia mieloide crônica (LMC), fazendo uso de Dasatinibe há 5 meses. Um ecocardiograma transtorácico foi realizado, revelando a presença de CIA e consequente hipertensão pulmonar (HP), que pode ter sido exacerbada pelo uso do agente quimioterápico, considerando que a HP é um efeito adverso conhecido da medicação conforme descrito na literatura. A conclusão deste estudo reforça a importância de uma abordagem abrangente, interdisciplinar e personalizada para um diagnóstico precoce, a fim de otimizar a terapêutica de maneira precisa e garantir a qualidade de vida do paciente.
The Diversity Index (IDIVERSA) has a new Environmental Social and Governance (ESG) strategy: Perspectives and challenges
Authors: Reinaldo Cristiano Melo , Pinto Francisco Roberto
Published: February 2025

This research aims to analyze whether IDIVERSA influences the disclosure of ESG information by regulated and non-regulated companies in [B]3. Specifically, it addresses the discussion of Agency Theory as one of the main monitoring tools for regulating conflicts of interest and presents some inferences about IDIVERSA's contribution to ESG and corporate governance of companies. The research is descriptive, quantitative, and documentary, and the population is made up of companies listed on [B]3 SA, consisting of 80 companies. The results showed that, unlike other existing indexes, this index works with a grouping thesis by considering the two socially marginalized groups, and this should help to induce ESG practices in the market and attract more investments. The research offers important contributions to the discussion related to gender and racial diversity that promote significant social, environmental and governance (ESG) disclosures by providing new evidence from companies listed on [B]3, which from the perspective of Agency Theory, are concerned with reputational and image risks and meeting the demand of investors concerned with sustainability, inclusion and diversity issues.
Impacto da nutrição e suplementação na prevenção da osteoporose em mulheres pós-menopáusicas: Uma revisão narrativa
Authors: Nery Sâmela Loiola Dourado , Santos Gerson de Souza , Jatobá Camila Dourado Franca , Quental Anielle Lucena de , Dourado Gabriel Franco Silva , Dourado Isadora de Lima , Carvalho Aline de Souza
Published: February 2025

Este estudo teve como objetivo sintetizar as evidências mais recentes sobre a relação entre nutrição e osteoporose na pós-menopausa, destacando a eficácia de intervenções nutricionais e suplementação. Busca oferecer uma visão abrangente, identificar lacunas no conhecimento e orientar pesquisas e práticas clínicas futuras. Foi realizada uma revisão narrativa da literatura científica recente sobre o efeito da suplementação de cálcio e vitamina D na densidade mineral óssea de mulheres pós-menopáusicas, considerando também a combinação dessas intervenções com atividades físicas. Os resultados indicaram que a suplementação de cálcio e vitamina D apresentou benefícios significativos, não apenas na manutenção da densidade mineral óssea, mas também na redução do risco de fraturas, especialmente quando associada a exercícios físicos focados em melhorar a força muscular e o equilíbrio. Práticas como yoga e treinamento funcional mostraram-se eficazes na redução do risco de quedas. Conclui-se que a suplementação de cálcio e vitamina D, combinada com programas de exercícios físicos, representa uma abordagem eficaz na prevenção de fraturas e no fortalecimento ósseo de mulheres pós-menopáusicas. Contudo, é fundamental a personalização do tratamento, e a continuidade de pesquisas sobre o impacto da nutrição nesta população são essenciais para otimizar os cuidados com a saúde óssea.
The Influence of E-Samsat Implementation, Taxpayer Awareness, and Income Levels on Compliance with Motor Vehicle Tax Payments
Authors: Suryadi Arief , Rahmat Nur , PurboJati Nurrakhman , Sunarsih Uun , Mais Rimi Gusliana
Published: February 2025

Tujuan penelitian ini adalah untuk menguji pengaruh penerapan sistem e-samsat, kesadaran wajib pajak, dan tingkat penghasilan terhadap kepatuhan pembayaran pajak kendaraan bermotor. Penelitian menggunakan metode kuantitatif. Data yang digunakan adalah data primer dengan cara menyebarkan kuisoner ke wajib pajak yang terdaftar di wilayah Jakarta timur dan teknik sampel menggunakan pursposive sampling dan diperoleh 50 responden. Uji prasyarat analisis menggunakan uji validitas, uji reliabilitas, uji normalitas, uji multikolinearitas, uji heterokedastisitas dengan menggunakan spss 25, kemudian analisa regresi linear dan uji parsial (uji t). Hasil dari penelitian adalah penerapan e-samsat tidak berpengaruh terhadap kepatuhan pembayaran pajak karena masih ada beberapa yang belum menerima sosialisasi terhadap e-samsat. Variabel kesadaran wajib pajak berpengaruh terhadap kepatuhan pembayaran pajak karena dengan adanya kesadaran maka wajib pajak turut serta dalam mendukung proses pembangunan, dan variabel tingkat penghasilan tidak berpengaruh terhadap kepatuhan pembayaran pajak.
Efektivitas Kampanye Digital Dalam Meningkatkan Partisipasi Pemilih Muda Pada Pemilihan Kepala Daerah Kota Semarang 2024
Authors: Rizky Muhammad
Published: February 2025

Pemilih muda (18–25 tahun) merupakan kelompok yang strategis dalam meningkatkan partisipasi demokrasi, namun sering kali kurang terlibat. Penelitian ini bertujuan untuk mengkaji pengaruh kampanye digital terhadap partisipasi pemilih muda pada Pilkada Kota Semarang 2024 dengan menggunakan teori media baru oleh Terry Flew dan teori agenda setting oleh McCombs dan Shaw. Penelitian mengadopsi metode kuantitatif dengan model regresi linier sederhana. Kuesioner dibagikan kepada 103 responden berusia 19–25 tahun di Kota Semarang untuk mengukur efektivitas kampanye digital sebagai variabel independen. Hasil penelitian menunjukkan nilai F sebesar 21,918 (sig < 0,05) dan koefisien regresi 0,387, yang menegaskan bahwa kampanye digital memiliki pengaruh signifikan dan positif terhadap peningkatan partisipasi pemilih muda. Efektivitas kampanye digital menjelaskan 17,8% variasi partisipasi pemilih muda, sementara sisanya dipengaruhi faktor lain. Temuan ini menunjukkan bahwa strategi kampanye berbasis media digital dapat meningkatkan kesadaran politik generasi muda, sejalan dengan teori media baru yang menekankan desentralisasi informasi dan interaktivitas. Penelitian ini memperkaya kajian komunikasi politik di era digital dan memberikan panduan strategis bagi kandidat politik dalam memanfaatkan media digital secara efektif. Dengan demikian, kampanye digital tidak hanya berperan sebagai alat komunikasi tetapi juga sebagai penggerak partisipasi politik pemilih muda.
Kata Kunci: Agenda setting; Kampanye digital, Media baru, Partisipasi politik, Pemilih muda
Optimalisasi Instagram Sebagai Media Pemasaran Sosial dalam Membentuk Kesadaran Lingkungan pada Generasi Z
Authors: Jaya Suman , Arswendi Riki
Published: February 2025

Indonesia berada diurutan ke-5 negara penyumbang sampah plastik ke laut terbesar. Sampah perlahan akan merusak ekosistem mulai dari mengubah rantai makanan dan merusak habitat biota laut. Dampak kerusakan yang semakin nyata akibat pencemaran sampah laut terutama berjenis plastik menggugah banyak pihak untuk memikirkan solusi penanganannya. Instragram merupakan sosial media yang memberikan layanan berbagi foto atau video secara daring. Selain itu, Instagram juga digunakan sebagai tempat orang berjualan secara online hingga kampanye sosial serta lingkungan. Kampanye untuk kebersihan lingkungan bukan sekadar aktivitas sosial, tetapi merupakan langkah konkret menuju perubahan positif. Melalui media sosial @pandawaragroup secara rutin membagikan informasi terkait jenis-jenis sampah, gambaran tentang kerusakan yang terjadi, serta mengajak masyarakat, terutama generasi Z (Gen Z) untuk aktif terlibat dalam upaya pelestarian lingkungan dengan aksi nyata membersihkan selokan, sungai dan pantai. Tujuan utamanya meningkatkan pemahaman tentang dampak kerusakan lingkungan serta memberikan panduan, motivasi tentang perilaku yang dapat mendukung pelestarian alam. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan analisis isi. Metode tersebut digunakan untuk memahami makna dalam teks tertulis atau data non-teks, seperti gambar atau rekaman suara. Hasil dari penelitian ini memberikan pemahaman yang lebih baik tentang bagaimana @pandawaragroup berperan dalam mengkampanyekan isu pelestarian lingkungan, dan bagaimana pesan-pesan mereka dapat mempengaruhi kesadaran dan tindakan masyarakat terkait permasalahan lingkungan, terutama terkait dengan sampah.
Kata Kunci: Generasi Z; Instagram; Kampanye; Pelestarian lingkungan
Introduction: Experience, Culture and Society: New Insights into Historical Analysis
Authors: Haapala Pertti , Harjula Minna , Kokko Heikki
Published: February 2025

The introductory article presents the history of experience as a new field that explores experiences in the socio-cultural world and their place in historical analysis. The article shows how experience as an analytic lens offers new conceptualisations of the past and its study by allowing one to look beyond the dichotomy of agency and structure. The introduction summarises how theoretical and methodological insights into temporality, spatiality, and social models of experience enrich the analysis of society, culture, and change.