bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural recovery of old crop fields in a South African Grassland biome
Authors: Coetzer Willem G. , Coetzer Kayleigh
Published: April 2023

Changing land-use practices has led to an increased rate of cropland abandonment in South Africa. Globally, climate change has increased the need for additional studies on the impact of land abandonment on soil health in arid and semi-arid environments. We, therefore, aimed to measure the changes in soil health with time following abandonment. The study site is located in the Winterberg Mountains of the Eastern Cape, South Africa. Standard soil characteristics were assessed for three recovering old crop fields. Samples from the surrounding natural habitat were also included for comparison. Significant positive changes in soil water-holding capacity and carbon and nitrogen characteristics were observed with increased age since abandonment, pointing to soil quality recovery. It will, however, still take a significant amount of time for total recovery to be achieved. Continuous monitoring of old crop fields in agricultural and formally protected areas is needed to fully understand the long-term effects of cropping on soil quality in this region.
Factors Associated with Receptive and Expressive Language in Autistic Children and Siblings: A systematic review
Authors: Mues Marjolein , Schaubroeck Sarah , Demurie Ellen , Roeyers Herbert
Published: April 2023

Background
Language abilities of autistic children and children at elevated likelihood for autism (EL-siblings) are highly heterogeneous, and many of them develop language deficits. It is as of yet unclear why language abilities of autistic children and EL-siblings vary, although an interaction of multiple influential factors is likely at play. In this review, we describe research articles that identify one or multiple of such factors associated with the receptive or expressive language abilities of autistic children and EL-siblings since the introduction of the DSM-5.
Aims
Our aim was to identify and summarize factors that are linked to language development in autistic children and siblings in the recent literature to ultimately gain insight into the heterogeneity of language abilities in these children.
Method
The search strategy of this review followed the PRISMA guidelines. The following databases were consulted: Embase, MEDLINE, Web of Science Core Collection and Scopus. Inclusion criteria for studies were the presence of a sample of autistic children no older than seven years old who were diagnosed with autism spectrum disorder per the criteria of the DSM-5. Intervention studies and studies without an explicitly reported language measure were excluded. Risk of bias assessment was completed using the Newcastle-Ottawa Scales. Ultimately 54 articles were included in this review.
Results
56 factors were identified to be related to receptive or expressive language abilities of autistic children and EL-siblings. They were grouped into three main categories: biological factors; psychosocial and environmental factors; and age-related and developmental factors, each with different subcategories. Although many of the identified variables were only examined in one article, some well-researched associated factors stood out, in particular joint attention, nonverbal cognitive abilities and frontal EEG power. Better insight in these factors shaping language abilities in autistic children and siblings at elevated likelihood can inform future intervention strategies to reduce language deficits and its corresponding negative consequences in these children
Conclusions
Our results confirm that multiple different factors likely underlie language deficits in autism. Important aspects that should be considered in such a model are, amongst others, social factors such as joint attention, child characteristics such as nonverbal cognition, and neurocognitive factors.
Associations between Blood Pressure Control and Documented Nutrition Care Using Structured Data from Electronic Health Records of Patients with Hypertension
Authors: Williams April , Britton Erin L , Thomson Maria D.
Published: April 2023

Background Documentation in Electronic Health Records (EHRs) of nutrition care events (overweight or obesity (BMI > 25 or 30, respectively) diagnoses, preventive care visits, or provision of patient education materials (PEM)) for chronic diseases is unclear.Methods Cross-sectional analysis using structured EHR data from primary care visits at a health system in the US from January 2018 - December 2020 of adult patients with hypertension (n = 6,419) tested for associations between last visit blood pressure (BP) control (≤ 140 Systolic BP and ≤ 90 Diastolic BP) and aggregate nutrition care events. Descriptive statistics and multiple logistic regression models were constructed to examine the predictive power of nutrition care events for blood pressure control.Results The median age was 62 years, 32% were male, 48% were Black, 26% were from rural areas and 35.9% had controlled BP at last visit. For the 62% of patients with documented nutrition care, 14.6% had an overweight/obesity diagnosis, 26.2% had a preventive care visit, and 42% received PEM with dietary and hypertension content. The models showed patients who had more preventive care visits (aOR 1.12; CL 1.06, 1.18) had higher odds for BP control. Whereas Black patients compared with white patients (aOR 0.84; CL 0.74, 0.95), those with more hypertension medications (aOR 0.97; CL 0.96, 0.99) and more primary care visits over the study period (aOR 0.98; CL 0.97, 0.99) had lower odds for BP control.Conclusions In this study, documented nutrition care in preventive care visits is significantly associated with BP control, but documentation is infrequent. Additional research should include examining clinical notes for evidence of nutrition care, which may uncover areas that show promise for improving nutrition care for patients with chronic disease.
Development of a robust TaqMan probe-based one-step multiplex RT-qPCR for Simultaneous detection of SARS-CoV-2 and influenza A/B viruses
Authors: Abbasi Hamidreza , Nikoo Hadi Razavi , Fotouhi Fatemeh , Khosravi Ayyoob
Published: April 2023

Background: During the coronavirus disease 2019 (COVID-19) pandemic, the simultaneous detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A/B viruses are essential in the rapid differential diagnosis in patients with similar symptoms. So far, several multiplex methods were published for simultaneous detection of SARS-CoV-2 and Flu A/B. However, due to the rapid mutation rate of the SARS-CoV-2 genome and the emergence of new variants, making it necessary to improve and update existing methods.
Methods: To identify a highly conserved region on SARS-CoV-2 N-gene, variant genome survey was performed to increase the sensitivity and specificity of primers and probe annealing to the SARS-CoV-2 genome. The analytical and diagnostic sensitivity and specificity of our multiplex RT-qPCR assay were determined; and the kappa agreement was calculated to highlight the agreement using the Chi-square test by SPSS 22.0.
Results: The new set of SARS-CoV-2 primer-probes designed in the present assay was able to detect all variants of concern (VOCs) and variants of interest (VOIs) with high analytical specificity among other respiratory viruses. The analytical sensitivity by our multiplex assay was ≤ 30 copies of the plasmid per reaction. A total of 70 clinical samples were analyzed using our multiplex assay and compared with multiplex commercial kit. The sensitivity of our multiplex RT-qPCR assay and commercial kit were 95.4% and 93.1%, respectively. Also, the specificity was the same (100%) in both methods. Kappa agreement was measured at 0.97 and 0.90 for our multiplex assay and commercial kit respectively.
Conclusions: A novel and robust TaqMan probe-based one-step multiplex RT-qPCR assay, with high analytical and clinical performance and agreement was developed and validated in this study. It will be valuable in influenza seasons when influenza expected co-circulate with SARS-CoV-2, due to saving costs, time, and consequently, specific and timely treatment of patients.
On the Location of the Nontrivial Zeros of the Riemann Zeta Function on the Critical Line
Authors: Arwashan Naji
Published: April 2023

In this paper we focus our attention on the zeta series ζ (s) = Σ∞n=1 1/ns in the domain of 0 < σ < 1 Even though the series is divergent in that domain, but we will find that its divergence will satisfy an asymptotic equation that involves the values of the zeta function in that same domain. Applying that equation to the critical line will lead us to a function that calculates the value of a convergent series of cosine waves; and interestingly we will find that the finite sum of that series is a combined wave that reorganizes the location of the nontrivial zeros of the Riemann zeta function on the critical line.
MSC code 11E45
Outcomes of incomplete abortion related to treatment modality
Authors: Sharvit Merav , Yagur Yael , Shams Rebecca , Daykan Yair , Klein Zvi , Schonman Ron
Published: April 2023

Purpose: This study evaluated the differences in treatment outcomes between misoprostol and surgical evacuation in the management of incomplete abortion.
Methods: This retrospective cohort study compared patients with clinical diagnosis of incomplete abortion who underwent surgical or pharmacological (misoprostol) intervention, between the years 2014–2017. Demographics, sonographic results, treatment follow-up, and post-intervention data on retained products of conception were retrieved. A comparison was made between women with incomplete abortion who underwent surgical versus pharmacological intervention.
Results: Among 589 spontaneous abortions, 198 were included in the study, of which 123 (62.1%) underwent surgical evacuation, and 75 (37.9%) pharmacological intervention with misoprostol. Baseline characteristics were similar between groups. During 130.8 ±91.7 days of follow-up, no patient who underwent surgical evacuation had retained products of conception or needed surgical hysteroscopy. Four cases (5.3%) in the misoprostol group had retained products of conception and needed hysteroscopy (p=0.02). Patients who underwent surgical evacuation had higher haemoglobin levels during follow-up (12.1 mg/dl vs. 11.7 mg/dl, p=0.05). No differences between groups in post-treatment pregnancy rates.
Conclusion: Long-term follow-up after incomplete abortion showed that hemodynamically stable patients treated with misoprostol achieved the desired results in 95% of cases without any clinical changes in haemoglobin level or pregnancy interval.
On the wake of propeller hydrokinetic turbines: Numerical simulations and experiments
Authors: Macías Marianela Machuca , Mendes Rafael Castilho Faria , Pereira Michael , Dobrev Ivan , Oliveira Taygoara Felamingo , Junior Antonio Cesar Pinho Brasil
Published: April 2023

The objective of this paper is to characterize the wake flow from a high-solidity propeller four-blade horizontal axis rotor commonly used in hydrokinetic turbines. A numerical and experimental study was conducted to describe the turbulent flow in the wake. Velocity flow measurements were obtained using PIV and hot-wire anemometry techniques in two different wind tunnel facilities. CFD simulations were carried out using a 3D full description of the rotating turbine rotor with an unsteady model. Additionally, simulations were conducted using a simplified model that described the rotor as actuator lines. The numerical results and experimental data were compared, and the study achieved good results for estimating machine performance and describing the main vortex structures in the turbine wake.
A novel narnavirus isolated from Colletotrichum curcumae strain 780-2T
Authors: Fu Yujia , Wang Tian , Zhou Siyu , Zhou Jingyi , Zhao Yang , Chen Daipeng , Zheng Li
Published: April 2023

The complete genome of a novel mycovirus, Colletotrichum curcumae narnvirus 1 (CcNV1), derived from the phytopathogenic fungus Colletotrichum curcumae strain 780-2T was sequenced and analyzed. The full sequence of CcNV1 is 3,374 bp in length and contains a single large open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp) of 1,087 amino acids with a molecular mass of 124.2 kDa that shares the closest similarity with that of Monilinia narnavirus H (53.02% identity). RdRp phylogeny analysis showed that CcNV1 is a new member of the genus Betanarnavirus within family Narnaviridae. This is the first report of a novel narnavirus infecting the phytopathogenic fungus C. curcumae, the causal agent of leaf blight of Curcuma wenyujin.
Intensification of alkali catalyzed transesterification of sunflower oil with methanol using rotor pulse cavitator
Authors: Nikolić Ivan , Bubanja Aleksandar R. , Jovanović Jelena D. , Adnađević Borivoj K.
Published: April 2023

Intensification of mass and heat transfer within a chemical reactor is of exceptional scientific and technological importance. Bearing that in mind, in this paper the effect of the following operational parameters of the alkali catalyzed transesterification of sunflower oil with methanol assisted by rotor pulse hydrodynamic cavitation (ACTO) was examined: contact time (tc); methanol to oil molar ratio (M1); concentration of the catalyst (Cc); temperature (T) and the number of passes of the reaction mixture (n) on the triglyceride conversion (TC) and cavitation yield (CY). ACTO was performed by a rotor pulse cavitation reactor (RPC) in single-pass mode. TC was determined by gas chromatography. The results show that already at tc=0.1s and n=1 a high TC=98% is achieved. Increasing the Cc value from Cc=0.3wt% to Cc=0.5wt% leads to an increase in the TC value from TC=0% to TC=98%. An increase in the value of M1 at a value of M1≥3 leads to an increase in the value of TC. An increase in the T of the reaction mixture causes a decrease in the value of TC. The established effect of operational parameters on TC and CY is explained by the influence of the selected operational parameter on the dissipation of kinetic energy in the reaction mixture caused by impulse and cavitation effects.
HIV-Related Knowledge and Health Care Seeking Barriers among Transgender Individuals in Dhaka City: A Cross-sectional Study
Authors: Rahman Md. Mantaka , Alam Ummul Khair , Prabawanti Ciptasari , Shimu Afroza Tamanna
Published: April 2023

Background: The prevalence of HIV among Transgender is 1% while only 0.9% in Dhaka City having one-third times a lifetime higher risk of HIV infection. Being minority group barriers faced by transgenders for healthcare-seeking are major public health concerns. Thus, the study aims to find out the HIV-Related knowledge & Health Care Seeking Barriers among Transgender Individuals in Dhaka City.
Methods: This was a cross-sectional study purposively selecting 135 transgender from Drop-in-center and three Hijra pollis of Dhaka City. Data was collected using a semi-structured questionnaire containing a Likert scale regarding HIV-related knowledge.
Results: Majority were professional sex sellers including 54.1% having irregular sexual clients while 48.9% had been engaged in sex work for more than 10 years. Although more than half (57%) had good HIV-related knowledge. Only one-third (37.3%) sometimes used barrier method and more than half (58%) had knowledge of HIV symptoms. The barriers were negligence (16%), inconvenient location (12.43%), shame (13.45%), judgmental (11.68%), fear (7.6%) and long waiting time (8.1%). Transgenders from Badda DIC had higher HIV-related knowledge compared to ones from hijra pollis [t (95% CI)=.168, p=.000] Those having HIV-related higher knowledge didn’t feel the necessity of isolated health corners [t (95% CI)= -3.799, p= .001]
Conclusion: Although DIC provides healthcare services, but existing facilities barriers need to be addressed to extend health services.
Echocardiographic measurements of left ventricular function in omphalocele with pulmonary hypertension
Authors: Yang Si-Si , Huang Wen-Chang , Wang Peng , Liu Tai-Xiang , Tou Jin-Fa , Gong Fang-Qi , Lai Dengming
Published: April 2023

Purpose: To compare echocardiographic parameters of left ventricular (LV) function in survival and death cohort of omphalocele neonates with pulmonary hypertension (PH), and explore the correlation with neonatal outcomes.
Methods: This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have severe malformations or chromosomal aberrations. Patients who died due to the management of palliative care were excluded. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal diameter diastolic (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others.
Results: There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Dead patients were comparable with survivors in the baseline characteristics. LVIDd, EDV, SV and CI were significantly worse in the death group, compared with survival group. These echocardiographic parameters were associated with death outcomes in omphalocele patients with PH.
Conclusion: LV function was significantly impaired in dead omphalocele neonates with PH, when compared with survivors. In the cohort of omphalocele patients with PH, LV dysfunction was associated with mortality.
Level of evidence: Level III
Different contributing processes in bacterial vs. fungal necromass affect soil carbon fractions during the plant residues transformation
Authors: Xue Zhijing , Qu Tingting , Li Xiaoyun , Chen Qin , Zhou Zhengchao , Wang Baorong , Lv XiZhi
Published: April 2023

Aims Recent research has suggested that microbial necromass has a disproportionate influence on soil organic C accumulation. But few field studies have followed the bacterial and fungal necromass vacations during plant residue decomposition.
Methods We investigated in a 512-days culture experiment with a perennial C3 herb (St.B, S. bungeana) to trace the formations of muramic acid (MurA) vs. Glucosamine (GluN), and investigate the relationships between MurA, GluN and soil C fractions.
Results The results showed that the bacteria community dominates the decomposition process due to soil pH (>7) and microbial metabolic C-, P-limitations. The dynamics of MurA changed from fluctuating variations to a significant increase. Bacterial necromass has been in a balance of accumulation and decomposition at early and middle periods. The entombing effect in the later stage resulted in bacterial necromass accumulation. While in the case of microbial metabolism limitation, GluN will lose its physicochemical protection and be degraded. Microorganisms regulate the turnover of POC, MAOC and MBC by microbial biomass and necromass. The utilization of soil C fractions is the direct cause of SOC decline, while microbial necromass only plays an indirect role. The priming effecting caused by one-time input of high C/N ratio plant residues leads to the absence of SOC accumulation in the short term.
Conclusions With the synergistic effect of soil C fractions, the production of microbial biomass and the degradation of cellular residues maintain microbial stoichiometric homeostasis. In addition to soil pH, microbial biomass stoichiometry co-determines microbial necromass formation.
Feasibility of a new clinical journal club implementation and its association with knowledge, attitudes, and application of evidence-based practice among chiropractic students and trainees: a before-and-after healthcare education improvement study
Authors: Häusler Melanie , Lalji Rahim , Hofstetter Léonie , Hincapié Cesar A.
Published: April 2023

Background Evidence-based practice (EBP) is the integration of best research evidence with clinical expertise and patients’ values and preferences. Little is known about knowledge, attitudes, and application of EBP among chiropractic students and trainees. Our aims were to (1) examine the feasibility of implementing a new journal club format within a Swiss university chiropractic healthcare education setting, and (2) assess the associations between the new journal club implementation and EBP characteristics among chiropractic students.Methods A before-and-after study was conducted through a newly implemented journal club with 5th and 6th year chiropractic students and postgraduate trainees between 1 February 2021 and 31 July 2021. The journal club was developed based on the “community of practice” and “team-based learning” conceptual frameworks. EBP knowledge, attitudes, personal application, and future use, were assessed with a validated questionnaire. We summarised participant characteristics using descriptive statistics, estimated before-and-after EBP total and subscale scores (i.e., knowledge, attitudes, personal application, and future use), and conducted an exploratory subgroup analysis based on journal club attendance (Group A: 3–5 and Group B: ≤ 2 sessions attended).Results Among 32 eligible students and trainees, 29 participants (mean age 26 years; 79% women) were enrolled: 25 (78%) responded to the pre- and 29 (91%) to the post-assessment surveys. Most (80%) were chiropractic students and 20% were postgraduate trainees. Group A consisted of 12 (41%) and Group B of 17 (59%) participants, respectively. We found reasonable feasibility for the new journal club format and our findings were compatible with no difference in before-and-after EBP scores (median EBP total score before: 72.6 [IQR, 63.7–77.4], and after: 73.4 [IQR, 61.3–78.2]). Exploratory subgroup analyses based on journal club attendance were consistent with our overall findings.Conclusion Our study suggests that the newly implemented journal club and embedding chiropractic educational research within the journal club were feasible and acceptable. Small before-and-after differences in the EBP subscale scores for knowledge, attitudes, personal application, and future use were observed in chiropractic students and postgraduate trainees. The small study size and short timeframe during a single semester limit potential inferences.
Lymphoscintigraphy findings in patients with chylothorax: influence of biochemical parameters
Authors: Zhang Li , Zhang Xiaoyue , Wen Zhe , Tong Guansheng , Hao Kun , Qiu Yongkang , Kang Lei
Published: April 2023

Background Chylothorax is a condition that can be challenging to diagnose due to its nonspecific clinical presentation. Several biochemical parameters of chylous pleural effusion have been identified as important indicators for the diagnosis of chylothorax. Lymphoscintigraphy, a non-invasive imaging technique, is also used to evaluate chylothorax and determine the location of chyle leakage. This study aimed to evaluate the correlation between the biochemical parameters of chylous pleural effusion and 99mTc-dextran (DX) lymphoscintigraphy in diagnosing chylothorax.
Material and methods A total of 120 patients were enrolled, 83 of the patients had unilateral chylothorax, and 37 had bilateral chylothorax. All patients conducted both 99mTc-DX lymphoscintigraphy and pleural effusion laboratory analysis. The images were classified into positive and negative groups based on whether an abnormal accumulation of the radioactive tracer was observed in the thorax on 99mTc-DX lymphoscintigraphy. And the biochemical parameters of the two groups were compared.
Results Among these patients, 101 (84.17%) had exudative effusions, and 19 (15.83%) had transudative effusions, according to the levels of pleural effusion protein, lactate dehydrogenase and cholesterol. Abnormal tracer accumulation in thorax was observed in 83 patients (69.17%). Exudative and transudative chylothorax are not associated with lymphoscintigraphy results (P = 0.597). In all biochemical parameters, lymphoscintigraphy positive group had significantly higher levels of pleural effusion triglyceride and pleural effusion triglyceride/serum triglyceride ratio compared with negative group (P = 0.000 and P = 0.005). The cutoff values that we identified for pleural effusion triglycerides and pleural effusion triglyceride/serum triglyceride ratio were 2.870 mmol/L and 4.625, respectively, which can facilitate differentiating the positive and negative results on lymphoscintigraphy.
Conclusion Lymphoscintigraphy technique is a reliable diagnostic tool for the qualitative evaluation of chylous pleural effusion. Higher pleural effusion triglyceride level and pleural effusion triglyceride/serum triglyceride ratio indicate a positive result in patients with chylothorax on lymphoscintigraphy, and the cutoff values of 2.870 mmol/L and 4.625 can help with the diagnosis.
Effects of Cognitive Behavioral Therapy on Adult Cancer Patients’ Resilience: A Systematic Review and Meta-Analysis
Authors: xiang lina , wan hongwei , zhu yu , zheng mimi , li xiaoru , wang shuman
Published: April 2023

PURPOSE Resilience is ability, outcomes, or processes to an individual's ability to adapt well in the face of significant adversity, which can improve the people’s coping strategies, decrease the level of psychological distress; however, the effect of psychological therapies for resilience remains unknow. Therefore, we systematically evaluate the effect of psychological therapies on the resilience in cancer patients.
METHODS We conducted keyword-based searches in PubMed, Cochrane, PsycINFO, CINAHL, and Embase databases. Two researchers independently conducted a strict evaluation for the overall quality of evidence by using the GRADE system and independently performed a data extraction, take meta-analysis by calculating the effect size of the experimental group, exploring the effects of psychological therapies on increasing resilience (PROSPERO registration no.:CRD42021256841).
RESULTS There were 12 RCTs (all studies were included in meta-analysis) which be reprsented by Cohen’g were found both at the phase of post-intervention ( Z=4.98; 95% CI, 0.767 to 1.762; p<0.001) and at follow up (Z= 3.71; 95% CI, 0.9 to 1.819; P<0.001). The effect of face-to-face CBTs (Z=14.07) were larger than those of online CBTs (Z=10.72, β=0.85;P=0.02). A GRADE evaluation revealed evidence of sufficient strength for the effect of CBTs on psychological resilience.
CONCLUSIONS Psychological therapies can significantly improve the resilience in cancer patients, which maintained at follow up. The most widely used skills in CBTs is rumination, attentional bias and cognitive modification, which committed to changing the way of thinking in which the patients relates to his or her past inner experiences. Future researches could investigate how to further optimize psychological therapies to enhancing cancer patients’ resilience.
Traveling Salesman Problem solution using Magnonic Combinatorial Device
Authors: Balinskiy Mykhaylo , Khitun Aleksandr
Published: April 2023

Traveling Salesman Problem (TSP) is a decision-making problem that is essential for a number of practical applications. Today, this problem is solved on digital computers exploiting Boolean-type architecture by checking one by one a number of possible routes. In this work, we describe a special type of hardware for the TSP solution. It is a magnonic combinatorial device comprising magnetic and electric parts connected in the active ring circuit. There is a number of possible propagation routes in the magnetic mesh made of phase shifters, frequency filters, and attenuators. The phase shifters mimic cities in TSP while the distance between the cities is encoded in the signal attenuation. The set of frequency filters makes the waves on different frequencies propagate through the different routes. The principle of operation is based on the classical wave superposition. There is a number of waves coming in all possible routes in parallel accumulating different phase shifts and amplitude damping. However, only the wave(s) that accumulates the certain phase shift will be amplified by the electric part. The amplification comes first to the waves that possess the minimum propagation losses. It makes this type of device suitable for TSP solution, where waves are similar to the salesmen traveling in all possible routes at a time. We present the results of numerical modeling illustrating the TSP solutions for four and six cities. Also, we present experimental data for the TSP solution with four cities. The prototype device is built of commercially available components including magnetic phase shifters/filters, coaxial cables, splitters, attenuators, and a broadband amplifier. The device literally shows the shortest route between the four selected cities. There are three examples of finding the shortest route between the cities for three different sets of city-to-city distances. The ability to exploit classical wave superposition is the most appealing property of the demonstrated device. It allows us to check a number of possible routes in parallel without any time overhead. It provides a fundamental advantage over conventional digital computers in functional throughput. The proposed approach is scalable to TSP with a larger number of cities. The estimated functional throughput of the combinatorial device for TSP with 25 cities exceeds 1035 Ops/s∙m2 which is above the limits of the existing supercomputers combined. Physical limits and challenges are also discussed.
Gestational Sac Discriminatory Levels of Serum HCG in Early Pregnancy Resulting in Live Birth
Authors: Park Kristen E , Latack Kyle R , Vestal Nicole L , Ingles Sue A , Paulson Richard J , Awadalla Michael S
Published: April 2023

Our primary objective is to verify or refute a 2013 study by Connolly et al. which showed that in early pregnancy a gestational sac was visualized 99% of the time on transvaginal ultrasound when the HCG level reached 3,510 mIU/mL. Our secondary objective was to make clinical correlations by assessing the relationship between human chorionic gonadotropin (HCG) level in early pregnancy when a gestational sac is not seen with pregnancy outcomes of live birth, spontaneous abortion, and ectopic pregnancy. This retrospective study includes 144 pregnancies with an outcome of live birth, 87 pregnancies with an outcome of spontaneous abortion, and 59 ectopic pregnancies. Logistic regression is used to determine the probability of visualizing a gestational sac and/or yolk sac based on HCG level. A gestational sac is predicted to be visualized 50% of the time at an HCG level of 979 mIU/mL, 90% at 2,421 mIU/mL, and 99% of the time at 3,994 mIU/mL. A yolk sac was predicted to be visualized 50% of the time at an HCG level of 4,626 mIU/mL, 90% at 12,892 mIU/mL, and 99% at 39,454 mIU/mL. 90% of ectopic pregnancies presented with an HCG level below 3,994 mIU/mL. These results are in agreement with the study by Connolly et al. Since most early ectopic pregnancies had an HCG value below the discriminatory level for gestational sac visualization, other methods for evaluation of pregnancy of unknown location such as repeat HCG values are clinically important.
Robust Speech Recognition in Sports Competition Review based on Natural Language Processing
Authors: Wang Penglong , Feng Yuhong , Xi Yongping , Yang Shengdong
Published: April 2023

Mass communication media is developing at a fast speed, and they have obtained richer methods through different ways of combining, which has attracted people's attention even more. There are many steps in sports competition review, and this article is to study these necessary steps. Sports commentary seems easy, but it is not simple. It includes many links, the content of the explanation should be substantial, and there are many requirements for the language, and at the same time, the emotions of the explanation must be grasped. Every link has a requirement. After summarizing experience, this chapter will rationally use the theory of natural language processing and another theory of robust speech recognition, so as to master each basic link, explain it, and understand the basic laws necessary for review . This article comprehensively describes the robust speech recognition technology, classifies and summarizes several aspects, and conducts more detailed research and discussion on improving its performance. Robust speech recognition systems will always have some problems about mismatch, which requires continuous innovation of some new acoustic models, so that they can be more adapted to the environment. In order to make better use of robust speech recognition performance, in this article, it has innovated the characteristics of its speech, and optimized the parameters and the front-end and back-end cooperation. In this way, it can be better with The combined use of natural language allows commentators to innovate better and increase the popularity of sports competition reviews.
Moving Image Recognition in Virtual Physical Education System based on adaptive algorithm
Authors: Feng Yuhong , Wang Penglong , Yang Shengdong , Xi Yongping
Published: April 2023

The use of virtual sports platform is a correct understanding of sports for students, which is also very useful and can stimulate students' initiative to master sports knowledge. In school physical education, the use of online education platforms can lead to the original physical exercise restrictions, eliminate the difficulty of lack of sports facilities and sports resources, and can better enhance students’ enthusiasm for sports. The action recognition system is a highly accurate system that can determine the training content according to the user's own training characteristics, and assist athletes or students to perform various actions in a more standard manner. Voice transmission technology is widely used in teaching, and it is widely used in the development of intelligent mobile. For motion detection, the main process starts from detection. The equipment reads the basic information of the experimenter, and then prepares for the test. This article mainly focuses on the language collection center in education and teaching. First, it introduces the theoretical analysis of language coding and on this basis introduces the solution of voice sensor node. This solution can not only complete the two-way processing of voice data and Transmission, and a single voice node can be used in the physical education system.
Identification and immunological characterization of cuproptosis-related molecular clusters in retinoblastoma
Authors: Shu qinxin , Ran Shengming , Gao Xu
Published: April 2023

Background: To proposed a novel strategy for retinoblastoma (RB) treatment and study by positing a connection between cuproptosis and immunological changes and the development and incidence of RB.
Methods: Using "Retinoblastoma" as the search phrase, two microarray datasets of Retinoblastoma (GSE208143 and GSE97508) were obtained from the GEO database. 42 samples of retinal tissue were collected, comprising 33 samples from Retinoblastoma patients and 9 samples from healthy individuals in the GEO database.
Results: We carefully examined the immunological characteristics and differential expression of CRGs in normal and retinoblastoma people for the first time in this study and developed a unique machine learning model based on the selected genes that has the ability to forecast patients with accuracy.
Conclusion: Our bioinformatic analysis uncovered the relationship between CRGs and immune cells that have been infiltrated, revealed the significant immune heterogeneity among RB patients with distinct cuproptosis clusters, and created a signature machine learning model based on the chosen genes that could accurately predict the patients.
Image Cutting in Video Media Technology Application based on Detection Algorithm
Authors: Jiahui Xiong
Published: April 2023

Speech activity detection algorithm belongs to a kind of means to judge the audio section and non audio section. Audio information diagnosis is composed of audio and noise section, and special treatment means are used for different signals. In the real model test, we can understand that RBF core has super stable attributes compared with other models, and has good self-renewal ability. In the audio information discrimination attribute diagnosis, we can understand the upgrading calculation process, and understand the large-scale counting audio information discrimination calculation process. The removal of pictograph is the primary obstacle to the solution scope of visual information. In the real use process, the classified noises are stored in the image removal with different attributes on a large scale, which plays a great role in the gradual diagnosis of image removal such as image upgrade and image classification. Therefore, in order to update the image level, eliminate the noise object and gradually diagnose the image, exploring the image removal method has become the first influential step in the first step of image diagnosis.. In the era of interconnection, we began to further explore the merging means model of interconnection, visualization and information interoperability, focusing on the governance of the merging and upgrading means model on the premise of interconnection, visualization and information interoperability, We can also apply multi-channel upgrading to upgrade our own hardware and software strength, observe and learn the quality level of the mode and class, so that the practical role of the means of mutual transmission of interconnected visual information can go on for a longer time.
Clinical, immunological, and genetic findings in Iranian patients with MHC-II deficiency: confirmation of c.121delG RFXANK founder mutation in the Iranian population
Authors: Khorshidi Mohadese-sadat Musavi , Seeleuthner Yoann , Chavoshzadeh Zahra , Behfar Maryam , Hamidieh Amir Ali , Alimadadi Hosein , Sherkat Roya , Momen Tooba , Behniafard Nasrin , Eskandarzadeh Shabnam , Mansouri Mahboubeh , Behnam Mahdiyeh , Mahdavi Mohadese , Zadeh Maryam Heydarazad , Shokri Mehdi , Alizadeh Fatemeh , Movahedi Mahshid , Momenilandi Mana , Olyaei Nasrin Alipour , Keramatipour Mohammad , Casanova Jean-Laurent , Cobat Aurélie , Abel Laurent , Shahrooei Mohammad , Parvaneh Nima
Published: April 2023

Purpose: Major histocompatibility complex class II (MHC-II) deficiency is a rare inborn error of immunity (IEI). Impaired antigen presentation to CD4+ T-cells results in combined immunodeficiency. Patients typically present with severe respiratory and gastrointestinal tract infections at early ages. Hematopoietic stem cell transplantation (HSCT) is the only curative therapy.
Methods: We describe the clinical, immunologic, and genetic features of eighteen unrelated Iranian patients with MHC-II deficiency.
Results: Consanguinity was present in all affected families. The median age at the initial presentation was 5.5 months (range seven days to 18 years). The main symptoms included failure to thrive, persistent diarrhea, and pneumonia. Autoimmune and neurologic features were documented in 30% of the patients, respectively.
Thirteen patients carried RFXANK gene mutations, two carried RFX5 gene mutations, and three carried a RFXAP gene mutation. Six patients shared the same RFXANK founder mutation (c.162delG); limited to the Iranian population and dated to approximately 1,296 years ago. Four of the patients underwent HSCT; three of them are alive. On the other hand, nine of the fourteen patients who did not undergo HSCT had a poor prognosis and died.
Conclusion: MHC-II deﬁciency is not rare in Iran, with a high rate of consanguinity. It should be considered in the differential diagnosis of combined immunodeficiency (CID) at any age. With the limited access to HSCT and its variable results in MHC-II deficiency, implementing genetic counseling and family planning for the affected families are mandatory. We better determined the c.162delG RFXANKheterozygous mutation frequency in the Iranian population.
The Effectiveness of Blended Versus Regular Forensic Outpatient Systemic Therapy in the Treatment of Juvenile Antisocial Behavior: A Study Protocol of a Randomized Controlled Trial
Authors: Cappellen S. Marjolein van , Creemers Hanneke E. , Hoogsteder Larissa , Horn Joan van , Dekovic Maja , Asscher Jessica J.
Published: April 2023

Background: Antisocial behavior during adolescence can have long-lasting negative effects and leads to high societal costs. Forensic Outpatient Systemic Therapy (Forensische Ambulante Systeem Therapie; FAST) is a promising treatment for juveniles aged 12-21 showing severe antisocial behavior. The intensity, content and duration of FAST can be adjusted to the needs of the juvenile and their caregiver(s), which is considered crucial for effective treatment. Next to the regular version of FAST (FASTr), a blended version (FASTb) in which face-to-face contacts are replaced by minimally 50% online contacts over the duration of intervention was developed during the Covid-19 pandemic. The current study will investigate whether FASTb is equally effective as FASTr, and through which mechanisms of change, for whom, and under which conditions FASTr and FASTb work.Methods:A randomized controlled trial (RCT) will be carried out. Participants (N= 200) will be randomly assigned to FASTb (n= 100) or FASTr (n= 100). Data collection will consist of self-report questionnaires and case file analysis, and include a pre-test at the start of the intervention, a post-test immediately after the intervention, and a six month follow-up. Mechanisms of change will be investigated using monthly questionnaires of key variables during treatment. Official recidivism data will be collected at two-year follow-up.Discussion:This study aims to improve the effectiveness and quality of forensic mental health care for juveniles with antisocial behavior by studying the effectiveness of blended care, which has not been studied before in treatment of externalizing behavior. If found to be at least as effective as face-to-face treatment, blended treatment can help meet the urgent need for more flexible and efficient interventions in this field. In addition, the proposed study aims to unravel what works for whom, knowledge urgently needed in mental health care for juveniles with severe antisocial behavior.Trial registration:This trial was registered at ClinicalTrials.gov on 22-07-2022, registration number NCT05606978.
The predictive value of estimated pulse wave velocity combined with BMI for newly diagnosed diabetes
Authors: Chen Chengwen , Bao Wei , Chen Chunwei , Wang Wanhong , Liu Xin , Lu Ling , Fu Shuo , Wang Cheng
Published: April 2023

Purpose ePWV and BMI are closely related to the prediction of new-onset diabetes. The aim of this study was to evaluate the impact and predictive value of the combination of estimate pulse wave velocity (ePWV) and body mass index (BMI) on new-onset diabetic patients.Methods A secondary analysis of a cohort study conducted by rich health care was performed with a total of 211833 eligible subjects enrolled. Logistic regression analysis was used to identify factors influencing the occurrence of diabetes, and ROC curve analysis was used to evaluate the predictive value of ePWV, BMI, and their combination on new-onset diabetes.Results During a mean follow-up period of 3.12 years, 3000 men (1.41%) and 1174 women (0.55%) were diagnosed with diabetes. Logistic regression analysis showed that BMI, triglycerides, alanine aminotransferase, blood urea nitrogen, creatinine clearance rate, ePWV, and history of diabetes in the family were high-risk factors for new-onset diabetes. Compared with using ePWV or BMI alone, the combined ePWV and BMI had a higher area under the receiver operating characteristic curve of 0.822.Conclusion The elevation of ePWV and BMI levels is an independent risk factor for new-onset diabetes, and the combination of ePWV and BMI can better predict new-onset diabetes compared to using either indicator alone.
Development of Nomogram for Predicting Major Complications in Patients with Esophageal Cancer in the Early Postoperative Period
Authors: Mijiti Maimaiti , Li Dan , Yuan Tingting , Zhao Dan , Shen Guimei , Yan Rui
Published: April 2023

Purpose To investigate the predictive value of the Prognostic Nutrition Index (PNI) in major complications after esophagectomy for esophageal cancer and to develop a Nomogram risk prediction model.Method The clinical data of 386 patients who underwent radical esophageal cancer surgery from December 2017 to December 2021 were retrospectively analyzed. Logistic regression analysis was performed to screen independent risk factors associated with major postoperative complications. A nomogram risk prediction model for major postoperative complications was developed based on the predictors, and the clinical utility of the model was assessed by decision curve analysis(DCA).Result In this study logistic univariate regression analysis found that age, preoperative radiotherapy, American Society of Anesthesiologists physical status (ASA score), length of surgery, and PNI may be associated with the development of major postoperative complications. logistic multifactorial analysis showed that the above risk factors were independent risk factors for the development of major postoperative complications in esophageal cancer. Nomogram was developed by incorporating the above risk factors with ASA classification. The calibration curves showed that the model had a good agreement. The decision curves showed that the model has good clinical application.Conclusion Individualized nomograms based on PNI combined with clinical indicators can be used to predict major complications in the early postoperative period and help to enhance perioperative management.
A Wavelet Selection Scheme and Its Application in Underwater Discharge Signal Analysis
Authors: Zhang Xiaobin , Lu Binjie , Qiao Liang
Published: April 2023

The time-frequency characteristics of underwater discharge explosion signals are of great significance for its application. Wavelet-based de-noising and time-frequency analysis technology is an effective means to study underwater explosion signals. The selection of wavelets is the key to the accuracy of wavelet analysis. Evaluation indexes are chosen and fused by the coefficient of variation. And a scheme of wavelet selection is provided based on the typical reference waveform and comprehensive evaluation index. The selected optimal wavelet is used to process the underwater discharge explosion signals produced by different materials. The results show that the scheme is feasible and practical.
­­Assessment of Joint and Interactive Effects of Multimorbidity and Chronic Pain on ADRD Risk in the Elder Population
Authors: Khalid Sumaira , Innes Karen , Umer Amna , Lilly Christa , Gross Diane , Sambamoorthi Usha
Published: April 2023

Objective Multimorbidity and non-cancer chronic pain conditions (NCPC) are independently linked to elevated risk for cognitive impairment and incident Alzheimer’s Disease and Related Dementias (ADRD)-both - We present the study of potential joint and interactive effects of these conditions on the risk of incident ADRD in older population.Methods This retrospective-cohort study drew baseline and 2-year follow-up data from linked Medicare claims and Medicare Current Beneficiary Survey (MCBS). Baseline multimorbidity and NCPC were ascertained using claims data. ADRD was ascertained at baseline and follow-up.Results NCPC accompanied by multimorbidity (vs. absence of NCPC or multimorbidity) had a significant and upward association with incident ADRD (adjusted odds ratio (AOR): 1.72, 95% CI 1.38, 2.13, p < 0.0001). Secondary analysis by number of comorbid conditions suggested that the joint effects of NCPC and multimorbidity on ADRD risk may increase with rising number contributing chronic conditions. Interaction analyses indicated significantly elevated excess risk for incident ADRD.