bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Outcome and Biomechanical Analysis of Dynamic Hip Screw Combined with Derotation Screw in Treating Displaced Femoral Neck Fractures Based on Different Reduction Qualities in Young Patients (≤65 Years of Age)
Authors: Zhu Jian , Li Yonglong , Zhang Yingze , Cheng Xiaodong
Published: January 2022

Objective. To examine the clinical results and biomechanical mechanism of the dynamic hip screw (DHS) and derotation screw (DS) in the treatment of displaced femoral neck fractures (FNF) based on different reduction qualities in young patients (≤65 years of age). Methods. All patients with FNF who received closed reduction and internal fixation with DHS+DS from January 2014 to August 2019 were retrospectively analyzed. Data on demographics, surgery, clinical outcomes, and postoperative complications were collected. According to the reduction quality immediately after surgery, all patients were categorized into the positive buttress reduction group (PBRG) and the anatomical reduction group (ARG). The complications and clinical outcomes were compared between the two groups. Meanwhile, the biomechanical mechanism of different reduction qualities was further analyzed with finite element analysis (FEA). The distribution of von Mises stress, the peak stress of internal fixation, and the displacement of the proximal fragment were compared between the two groups. Results. A total of 68 patients were included in our study. Among them, 31 were divided into the PBRG while 37 were in the ARG. The surgical time and fluoroscopy time were significantly shorter in the PBRG than in the ARG (p < 0.05). The degree of femoral neck shortening and the varus change of the femoral‐neck shaft angle were lower in the PBRG compared to the ARG (p < 0.05). The excellent‐good rate of the Harris hip score was higher in the PBRG compared to the ARG (83.9% vs. 64.8%). The FEA results demonstrated that the stress of DHS+CS and the downward displacement of the proximal femoral neck fragment were greater in the ARG than in the PBRG. Conclusion. For displaced FNF with difficulty to achieve reduction, DHS+CS combined with positive buttress reduction was an effective treatment in young patients due to better mechanical support, shorter surgical time, less radiation exposure, and higher excellent‐good rate of Harris hip score.
Effects of Computer-Based Cognitive Rehabilitation on Attention, Executive Functions, and Quality of Life in Patients with Parkinson’s Disease: A Randomized, Controlled, Single-Blinded Pilot Study
Authors: Svaerke Katrine , Faerk Andreas Kirknaes , Riis Asta , Stiegnitz von Ehrenfels Susanne Ebba Maja , Mogensen Jesper , Lokkegaard Annemette
Published: January 2022

Background: Cognitive decline in Parkinson’s disease (PD) has become increasingly recognized in recent years, and there is a need to identify methods for cognitive rehabilitation in PD patients. Objective: The aim of this study was to explore the feasibility and effects of 2 different computer-based cognitive rehabilitation (CBCR) interventions on attention, executive functions, and quality of life (QoL) in PD patients. Methods: Thirty nondemented PD patients were randomly assigned to one of 3 groups: one passive control group and 2 intervention groups with 2 different CBCR programmes. The intervention period was 8 weeks with follow-up visits in clinic every second week. Before and after the intervention period, patients were tested with a neuropsychological battery of attention, executive functions, and QoL. Results: Twenty-four patients completed the study. Patients in one of the CBCR groups experienced a significant within-group increase on the primary measures of attention, executive functions, and QoL. However, this effect was not significant between groups. No significant differences were observed for the other CBCR group or the control group. Conclusions: CBCR is a feasible intervention for cognitive rehabilitation in nondemented PD patients. The effects of training were modest and should be further explored in larger clinical trials. Some CBCR programmes might be more effective than others for PD patients. The protocol for this study was published prospectively at ClinicalTrials.gov on September 18, 2017 with ID: NCT03285347.
Cardiovascular Disease, Cancer, and Multimorbidity Interactions: Clinical Implications
Authors: Boudoulas Konstantinos Dean , Triposkiadis Filippos , Gumina Richard , Addison Daniel , Iliescu Cezar , Boudoulas Harisios
Published: January 2022

Background: With the aging population, the frequency of cardiovascular disease (CVD), cancer, and other morbid conditions is increasing dramatically. In addition, one disease may affect the other leading to a vicious cycle. Summary: With aging, the function of organs and systems of the human body declines including the immune system resulting in a diminished response to various pathogens and a chronic inflammatory process; these changes, in addition to other risk factors, contribute to the development of multiple morbid conditions including CVD and cancer. Multimorbidity in the elderly has become the rule rather than the exception today. Further, this association between CVD and cancer, at least partially, is explained by both diseases sharing common risk factors and from accelerated vascular aging due to cancer and its associated therapies. Multiple studies have shown that the incidence of cancer is much higher in patients with CVD compared to the general population. These associations among CVD, cancer, and their connection to systems of the human body provide an opportunity for novel therapies. Development of new drugs should be addressed to focus on multiple systems and not just only to one disease. Further, collecting information from registries and processing large amounts of data using artificial intelligence may assist the clinician when treating an individual patient in the future. Key Messages: As the aging population increases, CVD, cancer, and multimorbidity will continue to constitute a major health problem in the years to come. The physician who is taking care of such a patient, in addition to knowledge, requires clinical wisdom, clinical experience, and common sense in order to apply the continuous evolving knowledge to the individual patient.
Sex Differences in Plaque Composition and Morphology Among Symptomatic Patients With Mild-to-Moderate Carotid Artery Stenosis
Authors: van Dam-Nolen Dianne H.K. , van Egmond Nina C.M. , Dilba Kristine , Nies Kelly , van der Kolk Anja G. , Liem Madieke I. , Kooi M. Eline , Hendrikse Jeroen , Nederkoorn Paul J. , Koudstaal Peter J. , van der Lugt Aad , Bos Daniel
Published: January 2022

Background and Purpose:

Incidence of ischemic stroke differs between men and women, with substantially higher rates in men. The underlying mechanism of this difference remains poorly understood but may be because of differences in carotid atherosclerosis. Using an in-depth imaging-based approach, we investigated differences between carotid plaque composition and morphology in male and female patients with stroke, taking into account differences in total plaque burden. Additionally, we investigated all possible within-artery combinations of plaque characteristics to explore differences between various plaque phenotypes.

Methods:

We included 156 men and 68 women from the PARISK (Plaque At Risk) study, a prospective cohort study of patients with recent ischemic cerebrovascular symptoms and <70% ipsilateral carotid stenosis. Plaque characteristics (intraplaque hemorrhage [IPH], lipid-rich necrotic core [LRNC], calcifications, thin-or-ruptured fibrous cap, ulcerations, total plaque volume) were assessed with magnetic resonance imaging and multidetector-row computed tomography angiography. We used multivariable logistic and linear regression analyses to assess sex differences in plaque characteristics.

Results:

We found significant difference in total plaque volume between men and women (β=22.9 mm
3
[95% CI, 15.4–30.5]; mean volume in men 1399±425 mm
3
, in women 1011±242 mm
3
). Additionally, men were more likely to have IPH (odds ratio [OR]=2.8 [95% CI, 1.3–6.3]; IPH proportion in men 49%, in women 16%) and LRNC (OR=2.4 [95% CI, 1.2–4.7]; LRNC proportion in men 73%, in women 41%) even after adjustment for total plaque volume. We found no sex-specific differences in plaque volume-corrected volumes of IPH, LRNC, and calcifications. In terms of coexistence of plaque characteristics, we found that men had more often a plaque with coexistence of calcifications, LRNC, and IPH (OR=2.7 [95% CI, 1.2–7.0]), with coexistence of thin-or-ruptured fibrous cap/ulcerations, LRNC, and IPH (OR=2.4 [95% CI, 1.1–5.9]), and with coexistence of all plaque characteristics (OR=3.0 [95% CI, 1.2–8.6]).

Conclusions:

In symptomatic patients with mild-to-moderate carotid stenosis, men are more likely to have a high-risk carotid plaque with IPH and LRNC than women, regardless of total plaque burden. Men also have more often a plaque with multiple vulnerable plaque components, which could comprise an even higher stroke risk.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01208025.
Weaving Together a Decolonial Imaginary Through Design for Effective River Management: Pluriversal Ontological Design in Practice
Authors: Barcham Manuhuia
Published: January 2022

Looking at how we, as designers, can move beyond charges of neo-colonialism in social design, this article uses the empirical example of a design project focused on the restoration of a riverine system in New Zealand to provide an outline of ways that pluriversal ontological design can occur in practice. Exploring how the use of design tools and frameworks (e.g., boundary objects and infrastructuring) can help build out a decolonial imaginary, the article demonstrates how— through our design practice— we are able to successfully acknowledge, and work with, different “ways of being” in the world.
Values that Matter: A New Method to Design and Assess Moral Mediation of Technology
Authors: Smits Merlijn , Ludden Geke , Peters Ruben , Bredie Sebastian J. H. , van Goor Harry , Verbeek Peter-Paul
Published: January 2022

In this article, we aim to strengthen the basis of designing for values, by relating it to philosophy of technology. We start by discussing several theories to understand technology-induced value mediation: mediation approach, technology assessment methods, and types of value change. We continue by connecting these theories to design practice by proposing a new design for values methodology: Values that Matter. This methodology provides the means to evaluate moral mediation of technology during the design process and to responsibly design for it. The methodology is explained by the redesign of continuous vital sign monitoring technology in hospitalized patients.
A new species of eyeless Lymantes Schoenherr (Coleoptera: Curculionidae: Molytinae: Lymantini) from Texas caves
Authors: ANDERSON ROBERT S.
Published: January 2022

A new eyeless cave-inhabiting species of the weevil genus Lymantes Schoenherr (Coleoptera: Curculionidae: Molytinae: Lymantini) is described.  Lymantes reddelli Anderson, new species, occurs in caves in Bexar and Travis Counties, Texas, United States of America.  The new species is very similar to Lymantes nadineae Anderson but is found in caves south of the Colorado River whereas L. nadineae is only known from caves north of the Colorado River. Characters of external morphology and male genitalia to separate the species are given.
Effect and Mechanism of LncRNA HOTAIR on Migration, Apoptosis and Proliferation of Hepatocellular Carcinoma Cells
Authors: Quan Gang , Ren Bo , Xu Jian , Zhou Jie , Wu Guo , Li Qiang , Li Jingdong
Published: January 2022

Objective:
 This study was designed to probe the influence and mechanism of lncRNA HOTAIR on migration, apoptosis and proliferation of hepatocellular carcinoma (HCC) cells.

Methods:

We evaluated LncRNA HOTAIR expression in HCC tissues and adjacent tissues, and serum of HCC patients and healthy controls. Later, we knocked down lncRNA HOTAIR, and utilized CCK-8 to determine Hep3B cell proliferation, flow cytometry for prospecting Hep3B cell apoptosis, and cell scratch
assay for observing Hep3B cell migration.We anticipated the direct target of lncRNA HOTAIR, and adopted luciferase reporter assay to verify. Moreover, we inhibitedmiR-126-5p expression, and rescue experiment for evaluating the influence of si-HOTAIR+miR-126-5p inhibitors on Hep3B cell migration,
apoptosis as well as proliferation.

Results:
 Our results showed that lncRNA HOTAIR expression in tumor tissues and serum was significantly increased. Moreover, lncRNA HOTAIR inhibition significantly decreased the Hep3B cell proliferation
rate, elevated Hep3B cell apoptosis rate, and inhibited Hep3B cell migration. Luciferase reporter assay suggested that miR-126-5p was the direct target of lncRNA HOTAIR. Furthermore, co-transfection of si-HOTAIR+miR-126-5p inhibitor could diminishthe effects of HOTAIR silencing on apoptosis,
proliferation and migration.

Conclusion:
 Silencing of lncRNA-HOTAIR can inhibit the HCC cell migration and proliferation, and increase the apoptosis by up-regulating miR-126-5p expression.
Bone Marrow Mesenchymal Stem Cells (BMSC)-Derived MicroRNA-189 Inhibits Glioma Tumorigenesis Through Suppressing Tumor Necrosis Factor-α (TNF-α)-Mediated Nuclear Factor Kappa Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Pathway
Authors: Rao Wenxu , Yin Kang
Published: January 2022

This study aims at investigating the mechanism underlying bone marrow mesenchymal stem cells (BMSC) function in glioma. Glioma cells were administered with plasmids loading NF-κB siRNA, microRNA (miRNA)-189 inhibitor, or miR-189 mimics for transfection followed by analysis
of miR-189 expression by RT-qPCR, cell apoptosis by flow cytometry, cell proliferation by MTT assay,invasion and migration by Transwell assay, inflammatory factors secretion by ELISA as well as proteins expression by western blot. A mouse model of glioma was established to detect the in
vivo effect of BMSCs. miR-189 was lowly expressed in glioma cell lines but enriched in BMSCs. When miR-189 was silenced, cell proliferation, invasion and migration were potentiated and apoptosis was decreased, along with enhancement of N-cadherin, Vimentin, MMP-2 and and MMP-9, and decline
in Bax, cleaved casepase-3 and cleaved PARP. Silencing of NF-κB reversed the effect of miR-189 inhibitor on cell progression, accompanied with reduction of inflammatory factors. BMSCs treatment effectively promoted miR-189 expression in glioma and inactivated TNF-α/NF-κB
signaling, thereby suppressing tumor growth. In conclusion, miR-189 derived from BMSC inhibits glioma progression through regulation of TNF-α/NF-κB signaling pathway.
Evaluation of Stress on Acupuncture with Nano-Etched and Diamond-Like Carbon (DLC) Coating Surface Modifications
Authors: Yen Yung-Sheng , Cheng Han-Yi , Lin Hung-Ta
Published: January 2022

The aim of the present study was to investigate the effect of nano-etched surface and diamond-like carbon (DLC) surface acupuncture needles on human pain perception, by finite element method (FEM). Skin models were reconstructed by 3D computer programs. The stress is an important role
in acupuncture needle applications for clinical treatment. Many studies have investigated finite element researches for acupuncture; however, few have evaluated a model for acupuncture with and without\ modified surface. The results revealed that abnormal focusing stress was found when acupuncture
with nano-etched surface. Moreover, the unbalance stress was found on the top of the skin model in the nano-etched group, the highest stress also appeared in the top region. Acupuncture with nano-etched surface would be an effective means for stimulating skin. These results indicate subtle
but significant effects of acupuncture stimulation with nano-etched surface needles, compared to acupuncture with untreated needles in healthy participants.
Development and Characterization of Acrylic Based Bone Cements
Authors: Khan Aqsa , Khan Ghazna Hassan , Mirza Eraj Humayun , Chandio Alidad , Mohsin Maliha , Hassan Mahnoor , Naushad Manal , Jafri Ali Raza
Published: January 2022

Bone tissue engineering has emerged as a multidisciplinary field in recent times with an aim to expedite the process of regeneration of damaged or diseased tissues. This study is an attempt to fabricate and characterize Tricalcium Phosphate (TCP) and Chitosan incorporated Polymethylmethacrylate
(PMMA) based bone cement. In total two experimental PMMA based bone cements were fabricated that were differentiated by presence and absence of Chitosan. In both groups (10 and 30 wt.%) TCP were incorporated into Methyl methacrylate (MMA) monomer. PMMA was used as a control. The physical,
mechanical and thermal properties of the composites were assessed. Morphological changes of PMMA after the introduction of TCP and Chitosan were observed by means of X-ray diffraction (XRD). Major peak shifts in Fourier transform Infrared spectroscopy (FTIR) spectra demonstrated the strong
bonding of PMMA with incorporated materials. PMMA incorporated with 10% TCP showed the maximum wettability in absence of Chitosan. Hardness of the tested specimens decreased with increasing content of TCP which in turns enhanced ductility. It was also observed that neither of the samples showed
significant degradation. The incorporation of additives enhance the physical and chemical properties of PMMA as bone cement.
Gold Nanoparticle Drug Delivery System: Principle and Application
Authors: Xiang Qianrong , Wu Zhuoxuan , Tian Er-Kang , Nong Shiqi , Liao Wen , Zheng Wenyue
Published: January 2022

In recent years, gold nanoparticles (GNPs) have gradually become a major choice of drug delivery cargoes due to unique properties. Compared to traditional bulk solid gold, GNPs have basic physical and chemical advantages, such as a larger surface area-to-volume ratio and easier surface
modification. Furthermore, these have excellent biocompatibility, can induce the directional adsorption and enrichment of biological macromolecules, help retain biological macromolecule activity, and cause low harm to the human body. All these make GNPs good drug delivery cargoes. The present
study introduces the properties of GNPs, including factors that affect the properties and synthesis. Then, focus was given on the application in drug delivery, not only on the molecular mechanism, but also on the clinical application. Furthermore, the properties and applications of peptide
GNPs were also introduced. Finally, the challenges and prospects of GNPs for drug delivery were summarized.
Bone Marrow Mesenchymal Stem Cells Derived Discoidin Domain-Containing Receptor 2 (DDR2) as a Communication Mediator to Strengthen the Invasiveness and Metastasis of Papillary Thyroid Carcinoma
Authors: Xiao Xiongsheng , Zhang Zhi , Xie Hongpo , Li Siyi , Li Jianwen
Published: January 2022

Our current study plans to dissect the impacts and its underlying mechanisms of bone marrow mesenchymal stem cells (BMSCs) on the invasive and metastatic features of PTC. Clinical specimens from distantly metastatic PTC were collected to measure DRR2 level. After being identified via
tri-lineage differentiation and flow cytometry, BMSCs were co-cultured with PTC cells followed by analysis of cell proliferation and migration by CCK-8 and Transwell assays, expression of DDR2 and EMT-associated proteins by Western blot. Eventually, shDDR2-transfected BMSCs were infused with
PTC cells into the abdominal cavity of mice to establish a mouse model assess their effect on tumor growth and distant metastasis. DDR2 was upregulated in BMSCs and malignant cells located in the metastatic sites. Co-culture with BMSCs enhanced DRR2 expression in PTC cells, which was simultaneously
accompanied by the escalated mesenchymalization process. In vivo experiments exhibited that co-injection with BMSCs facilitated disease progression and distant metastasis of malignancies. Instead, DDR2 knockdown significantly impeded BMSCs-triggered migrative and proliferative behaviors
of malignant cells. In conclusion, DDR2 derived from BMSCs can function as a communication mediator to strengthen the invasiveness and metastasis of PTC.
Total hip arthroplasty in Cambodia – Our experience of two hundred and fifty six consecutive total hip arthroplasties in a low-income country & the challenge of service delivery in this setting
Authors: Shelton J , Dorman S , Long K , H Oy , Ngiep O , Gollogly J
Published: January 2022

The Children's Surgical Centre has performed 256 THAs since 2007, We aim to assess the outcome of arthroplasty in a LMIC. Primary outcome: all cause of re-operation, Secondary outcome: any other complication. A retrospective review of all consecutive THA since 2007 was conducted. Electronic and physical case notes were reviewed. Statistical analysis was performed using MedCalc. 256 THA. Mean age: 43, gender M2:1F. Common pathologies include (1) AVN (44%), (2) OA (11%) and (3) DDH (11%). Revision rate 13%. Time to revision was 2.8 years (0–9). Common revision reasons: (1) stem fracture (5.8%), (2) aseptic loosening (4.8%) and (3) infection (2.7%). Complications were identified in 85 patients (33.2%). Common complications included (1) aseptic loosening (10.5%) (2) stem fracture (5.8%) and (3) dislocation (5.8%). Patients at CSC benefit from THA, the complication rates at CSC are declining suggesting the apex of the ‘learning curve’ has passed. Cheap poorly manufactured implants continue to cause catastrophic failure.
‘More like a tavern than a school house’: Family strife, religious change, and the founding of Oundle Grammar School, 1556–1578
Authors: Alsop James
Published: January 2022

The convoluted and contested foundation of the Grammar School at Oundle, Northamptonshire, in 1573 illustrated the complexities involved in giving concrete shape to pious wishes in 16th-century post-mortem bequests. Although the founder was Sir William Laxton (d. 1556), the key figure was his widow, the assertive matriarch Dame Joan Kirkeby-Luddington-Laxton, the richest woman of early Elizabethan London. This paper analyses the politics, religious context, and family strife of this dispute, and in so doing illuminates the contours of early Elizabethan London.
Adherence to the Mediterranean Diet and Successful aging in Greeks living in Greece and abroad: the epidemiological Mediterranean Islands Study (MEDIS)
Authors: Papadimitriou Anastasia , Foscolou Alexandra , Itsiopoulos Catherine , Thodis Antonia , Kouris-Blazos Antigone , Brazionis Laima , Sidossis Amalia C. , Polychronopoulos Evangelos , Kokkinos Peter , Panagiotakos Demosthenes , Sidossis Labros S.
Published: January 2022

Background: Whether older immigrant populations from the Mediterranean region, continue to follow the MD long after they immigrated is not known. Aim: Compare adherence to the MD and successful aging levels between Greeks living in Greece (GG) and Greeks living abroad (GA). Methods: Anthropometrical, clinical, psychological, sociodemographic, dietary and lifestyle parameters were assessed in a cross-sectional manner in a sample of 252 GG and 252 GA. Mediterranean Diet Score (MedDietScore range 0-55) was used to assess adherence to the MD. Successful aging was evaluated with the validated successful aging index (SAI range 0-10). Results: GA presented higher adherence to MD (p < 0.001); they were consuming significantly more cereals, legumes, vegetables, and fruits compared to GG. GG consumed significantly more dairy (3.8 ± 2.9 vs. 1.9 ± 2.2, p < 0.001) and potatoes (2.4 ± 1.6 vs. 1.9 ± 1.5, p < 0.001) compared to GA. Meat ( p = 0.27), poultry ( p = 0.72), fish ( p = 0.68), olive oil ( p = 0.16) and alcohol consumption ( p = 0.05) were comparable between the two groups (all p’s > 0.05). MedDietScore was positively associated with SAI among both groups after adjusting for possible confounders (0.041 ± 0.014, p = 0.003 GG and 0.153 ± 0.035, p < 0.001 GA). Also, legumes, cereals, fruits and vegetables were found to be beneficial for successful aging. Conclusion: Adherence to the MD is associated with higher levels of successful aging among people of the same genetic background living in different environments. However, traditional dietary habits are gradually abandoned in their native countries, when, at the same time, are considered cultural heritage and preserved accordingly among immigrants.
Grateful expectations: Cultural differences in the curvilinear association between age and gratitude
Authors: Chopik William J. , Weidmann Rebekka , Oh Jeewon , Purol Mariah F.
Published: January 2022

Recent research suggests that the association between age and gratitude might be curvilinear—despite gratitude ostensibly being higher in middle-age, it might be lower in older adulthood. It is unclear if this curvilinear pattern of age differences in gratitude is found in other samples and whether its manifestation depends on contextual (i.e., national/cultural) characteristics. The current study examined cultural variation in the curvilinear effect of age on gratitude in a sample of over 4.5 million participants from 88 countries. Participants from countries with lower levels of human development, a shorter-term orientation, and higher levels of indulgence reported higher levels of gratitude. Cultural moderation effects were very small, suggesting that curvilinear effects of age on gratitude may be relatively comparable across cultures.
Feminist theory, method, and praxis: Toward a critical consciousness for family and close relationship scholars
Authors: Allen Katherine R.
Published: January 2022

Feminism provides a worldview with innovative possibilities for scholarship and activism on behalf of families and intimate relationships. As a flexible framework capable of engaging with contentious theoretical ideas and the urgency of social change, feminism offers a simultaneous way to express an epistemology (knowledge), a methodology (the production of knowledge), an ontology (one’s subjective way of being in the world), and a praxis (the translation of knowledge into actions that produce beneficial social change). Feminist family science, in particular, advances critical, intersectional, and queer approaches to examine the uses and abuses of power and the multiple axes upon which individuals and families are privileged, marginalized, and oppressed in diverse social contexts. In this paper, I embrace feminism as a personal, professional (academic), and political project and use stories from my own life to illuminate broader social-historical structures, processes, and contexts associated with gender, race, class, sexual orientation, gender identity, age, nationality, and other systems of social stratification. I provide a brief history and reflections on contemporary feminist theory and activism, particularly from the perspective of my disciplinary affiliation of feminist family science. I address feminism as an intersectional perspective through three themes: (a) theory: defining a critical feminist approach, (b) method: critical feminist autoethnographic research, and (c) praxis: transforming feminist theory into action. I conclude with takeaway messages for incorporating reflexivity and critical consciousness raising to provoke thought and action in the areas of personal, professional, and political change.
Experimental and numerical investigation on bending and compressive behavior of carbon-epoxy sandwich panel with novel M-shaped core
Authors: Khaledi Himan , Rostamiyan Yasser
Published: January 2022

Present paper has experimentally and numerically investigated the mechanical behavior of composite sandwich panel with novel M-shaped lattice core subjected to three-point bending and compressive loads. For this purpose, a composite sandwich panel with M-shaped core made of carbon fiber has been fabricated in this experiment. In order to fabricate the sandwich panels, the vacuum assisted resin transfer molding (VARTM) has been used to achieve a laminate without any fault. Afterward, polyurethane foam with density of 80 kg/m3 has been injected into the core of the sandwich panel. Then, a unique design was presented to sandwich panel cores. The study of force-displacement curves obtained from sandwich panel compression and three-point bending tests, showed that an optimum mechanical strength with a considerable lightweight. It should be noted that the experimental data was compared to numerical simulation in ABAQUS software. According to the results, polyurethane foam has improved the flexural strength of sandwich panels by 14% while this improvement for compressive strength is equal to 23%. As well as, it turned out that numerical results are in good agreement with experimental ones and make it possible to use simulation instead of time-consuming experimental procedures for design and analysis.
Advances in joining technologies for the innovation of 21st century lightweight aluminium-CFRP hybrid structures
Authors: Sandeep Renangi , Natarajan Arivazhagan
Published: January 2022

In the twenty-first century, the application of carbon fiber reinforced polymer (CFRP) materials in the vehicle industry are growing rapidly due to lightweight, high specific strength, and elasticity. In the automobile and aerospace industries, CFRP needs to be joined with metals to build complete structures. The demand for hybrid structures has prompted research into the combination of CFRP and metals in manufacturing. Aluminium and CFRP structures combine the mechanical properties of aluminium with the superior physical and chemical properties of CFRP. However, joining dissimilar materials is often challenging to achieve. Various joining technologies are developed to produce hybrid joints of CFRP, and aluminium alloys include conventional adhesives, mechanical and thermal joining technologies. In this review article, an extensive review was carried out on the thermal joining technologies include laser welding, friction-based welding technologies, ultrasonic welding, and induction welding processes. The article primarily focused on the current knowledge and process development of these technologies in fabricating dissimilar aluminium and CFRP structures. Besides, according to Industry 4.0 requirements, additive manufacturing-based techniques to fabricate hybrid structures are presented. Finally, this article also addressed the various improvements for the future development of these joining technologies. Ultrasonic welding yields the maximum shear strength among the various hybrid joining technologies due to lower heat input. On the other hand, laser welding produces higher heat input, which deteriorates the mechanical performance of the hybrid joints. Surface pretreatments on material surfaces prior to joining showed a significant effect on joint shear strength. Surface modification using anodizing is considered an optimal method to improve wettability, increasing mechanical interlocking phenomena.
Athlete Multiple Perpetrator Rape (MPR) as Interactional and Organizational Deviance: Heuristic Insights from a Multilevel Framework
Authors: Sutton James E.
Published: January 2022

Although athlete multiple perpetrator rape (MPR) has frequently been covered in the media, it has received more limited scholarly attention. Accordingly, I synthesize findings from multiple disciplines and integrate insights from the MPR, institutional betrayal, and organizational deviance literatures to establish a heuristic framework for understanding athlete MPR. I ultimately argue that athlete MPR is both an act of interactional deviance and an act of organizational deviance. This undertaking represents one of the only works to focus explicitly on athlete MPR. It is additionally the first to examine any form of sexual assault through an organizational deviance lens.
Functional Prediction of Biological Profile During Eutrophication in Marine Environment
Authors: Sbaoui Yousra , Nouadi Badreddine , Ezaouine Abdelkarim , Rida Salam Mohamed , Elmessal Mariame , Bennis Faiza , Chegdani Fatima
Published: January 2022

In the marine environment, coastal nutrient pollution and algal blooms are increasing in many coral reefs and surface waters around the world, leading to higher concentrations of dissolved organic carbon (DOC), nitrogen (N), phosphate (P), and sulfur (S) compounds. The adaptation of the marine microbiota to this stress involves evolutionary processes through mutations that can provide selective phenotypes. The aim of this in silico analysis is to elucidate the potential candidate hub proteins, biological processes, and key metabolic pathways involved in the pathogenicity of bacterioplankton during excess of nutrients. The analysis was carried out on the model organism Escherichia coli K-12, by adopting an analysis pipeline consisting of a set of packages from the Cystoscape platform. The results obtained show that the metabolism of carbon and sugars generally are the 2 driving mechanisms for the expression of virulence factors.
Health Literacy of Newly-Admitted Cancer Patients in Vietnam: Difficulties Understanding Treatment Options and Processing Health-Related Information
Authors: Dai Minh Le , Quang Bui Vinh , Ngoc Le Mai Duong , Quyen Le Le , Gia Nguyen Hoang , Hang Nguyen Thanh , Giang Kim Bao
Published: January 2022

Having a good understanding of cancer patients’ health literacy in the early stage of diagnosis can help to implement strategies to improve the management process and overall health outcomes. The study aims to describe health literacy and its association with socio-demographic characteristics among newly admitted cancer patients. A cross-sectional study was conducted on 262 newly admitted patients of a cancer hospital in Vietnam using the Vietnamese version of the HLS-SF12 questionnaire. Descriptive analytics and regression analysis were used to describe health literacy and examine associated factors. Older age, lower level of education, and living in rural areas were associated with lower health literacy while there was no significant relationship between gender and health literacy among newly admitted cancer patients. Many newly admitted patients, especially the older patients have difficulties understanding the different treatment options (54%) and evaluating the reliability of health information on the internet (43%). During the early stage of treatment, strategies should be implemented with regards to patients’ health literacy, to properly educate patients and their caregivers to improve communication, adherence to medication, lifestyle, and overall better quality of life and treatment outcome.
Edinburgh Postnatal Depression Scale (EPDS) for screening for depression in the first year post delivery in a low-resourced rural setting in Kenya
Authors: Mutiso Victoria N. , Musyimi Christine W. , Tele Albert , Alietsi Rita , Andeso Pauline , Ndetei David M.
Published: January 2022

Postnatal depression is one of the most common mental disorders among postnatal mothers and may have severe consequences for mothers and their children. Locally validated screening tools that can be self- or lay interviewer-administered are required to identify at-risk women, especially in settings with no mental health specialists. This study aimed to assess the validity and reliability of a culturally adapted version of the Edinburgh Postnatal Depression Scale (EPDS) in a local dialect (Kamba) in a Kenyan setting. Trained research assistants administered the local-language version of self-report scales (EPDS) to a sample of 544 Kamba-speaking women. The same scale was re-administered to the same research participants two weeks later by the same research assistants. The test scores were compared with an external ‘gold standard’ according to the DSM-IV criteria Mini-International Neuropsychiatric Interview for adults (MINI-Plus). The EPDS had an area under the curve (AUC) of 0.867 with 95% C.I of 0.836 to 0.894, with a cut-off point of ≥11, sensitivity of 81.0% (95% C.I 70.6–89.0) and specificity of 82.6% (95% CI 78.8–85.9). The positive predictive value (PPV) and negative predictive value (NPV) were 44.1% and 96.2%, respectively. The internal reliability was 0.852 and the test-retest reliability was 0.496. The EPDS showed good utility in detecting depressive disorder in Kamba-speaking postnatal women. It does not have to be administered by mental health workers (who are few in low- and middle-income countries); rather, this can be done by a trained lay interviewer.
Racial formation and education: A critical analysis of the Sewell report
Authors: Tikly Leon
Published: January 2022

The article provides an analysis and critique of the education component of the 2021 Sewell Report on Race and Ethnic Disparities. It commences by providing a critical summary of the report focusing on its spurious claims to objectivity, the erasure of racism and the inadequacy of its recommendations. The second part of the article focuses on developing a contextualised analysis of the report. Omi and Winant’s ideas about racial formation are used to provide a lens through which to interpret the Sewell report as part of a wider hegemonic project of the right to redefine what it means to be British in the context of a deepening organic crises of capitalism. The article outlines the nature of the crisis. It locates the report within a consideration of three ‘racial projects’ that have shaped education policy, namely, the nationalist, multicultural and antiracist projects. Through advocating a ‘colourblind’ approach to education policy and the selective appropriation of multicultural discourse, it will be argued that the report needs to be understood as part of a wider effort to reconfigure the nationalist project in response to crisis. It is suggested, however, that despite its many flaws, the Sewell report poses challenges for those who have traditionally been aligned to multiculturalism and antiracism in education. The article concludes by setting out a vision for a new progressive project aimed at advancing racial and cultural justice that it is suggested, can begin to address these challenges.
Leadership Styles and Psychological Empowerment: A Meta-Analysis
Authors: Schermuly Carsten C. , Creon Laura , Gerlach Philipp , Graßmann Carolin , Koch Jan
Published: January 2022

Psychological empowerment has become a popular construct in organizational research and practice. Leadership ranks high among the best predictors of employees’ psychological empowerment, yet little is known about which leadership styles prove more effective than others. This meta-analysis investigates the effects of four leadership styles on psychological empowerment. More specifically, we test whether empowering leadership evokes more psychological empowerment than transformational leadership, servant leadership, or transactional leadership. We found that empowering, transformational and servant leadership contribute almost equally to psychological empowerment. No relationship was found with transactional leadership. In an explorative manner, we tested the effects on the different dimensions of psychological empowerment. We found that the leadership styles had a weaker influence on the competence dimension of psychological empowerment. We also investigated the effects of several moderators on the relationships with psychological empowerment: country culture (power balanced freedom (PBF)), study design (cross-sectional vs. multi-wave studies) and publication status (published vs. unpublished). We found no moderating effects of culture, which indicates the universally empowering effects of the leadership styles. The relationships between leadership and empowerment were somewhat weaker when data were collected at different measurement points, and publication bias does not seem to be an issue in this research field.
Simulation of chromatic and achromatic assessments for camouflage textiles and combat background
Authors: Anowar Hossain Md
Published: January 2022

Chromatic and achromatic (AC) assessments of camouflage textiles have been critical to the defense researchers for concealment, detection, recognition, and identification (CDRI) of target signature against multidimensional combat background (CB). AC assessment and camouflage measurement techniques are simulated and experimented for assessment of camouflage textiles against CB. This model has been demonstrated for color measurement spectrophotometer, scanning electron microscopy (SEM), digital imaging, hyperspectral imaging, and image processing software (ImageJ) for the advancement and establishment of AC camouflage textiles assessment. The chromatic variations of 48 artificial target objects (TOBs) have been synthesized by image processing; the technique can be implemented for defense CB-CDRI assessment. Microstructural variation versus optical signal of woodland, desertland and stoneland CB materials have been elucidated by SEM magnification. The achromatic variation of CB materials have been demonstrated for the replacement of optical signal against modern remote sensing device to the imaging sensor. Color difference (Δ E), microstructural variations, pixel variations to imaging signal and standard deviation of CB materials have been represented for remote sensing surveillance of defense applications against TOB-CB-CDRI. Technical simulation of color, texture, gloss, and pixel intensity has been derived for AC-CDRI assessment of camouflage textiles in TOBs-CB environment.
Indication-based protocols with different solutions for mechanical stromal-cell transfer
Authors: Copcu H Eray
Published: January 2022

Background

Regenerative medicine is the fastest developing branch of plastic surgery in recent times. Adipose tissue is one of the largest and most important sources in the body for stromal cells. Although mechanical isolation methods are both very popular and have many advantages, they still have no accepted protocols.

Objective

We developed new protocols called indication-based protocols (IPs) for standardization and new techniques called mechanical stromal-cell transfer (MEST) by using ultra-sharp blades and dilution of adipose tissue with different solutions (saline, Ringer and 5% Dextrose) Methods & material: In order to obtain the desired physical structure (liquid, gel, solid) and the desired volume, four different types of IPs have been defined. Adipose tissue was prediluted with different solutions using 10 or 20 cc injectors in IPs 1 and 2, while condensed adipose tissue was used directly in IPs 3 and 4.

Results

In MEST, stromal cells were obtained from 100 mL of condensed fat using different IPs with 92% mean viability and cell counts of 26.80–91.90 × 106. Stromal cells can be obtained in the desired form and number of cells by using four different IPs.

Conclusion

Isolation of stromal cells by cutting fat with sharp blades will prevent the death of fat tissue and stromal cells and will allow high viability and cell count with our new technique. Predilution with different solutions: Diluting the condensed adipose tissue with the desired solutions (saline, Ringer or 5% Dextrose) before the adinizing process will provide even more stromal cells.

Lay Summary

Obtaining regenerative stromal cells from adipose tissue can be done by two methods: Enzymatic and mechanical. Mechanical methods have many advantages. Although mechanical stromal cell extraction from adipose tissue is very popular and many techniques have been described, there are still no accepted protocols, definition for the end product, and no consensus on the status of the stromal cells. In this study, stromal cells were obtained mechanically by using ultra-sharp blade systems, without exposing adipose tissue to blunt trauma. Thus, a higher number of cells and higher viability could be obtained. An “Indication based” protocol has been defined for the first time in order to obtain the desired number and status (solid, semi-solid, liquid) end product. Diluting the condensed adipose tissue with the desired solutions (saline, Ringer or 5% Dextrose) before the adinizing process will provide even more stromal cells. This will provide an opportunity for clinicians to obtain and apply a stromal cell solution for different indications in different anatomical regions.
Treatment of subacute/chronic ECU tendinopathy using wrist arthroscopy and open surgical repair
Authors: Lee Young-Keun
Published: January 2022

Purpose

To report the arthroscopic and clinical findings of patients with extensor carpi ulnaris (ECU) tendinopathy treated with wrist arthroscopy and open surgical repair.

Methods

We retrospectively reviewed the medical records of seven patients with chronic ECU tendinopathy who were treated with diagnostic wrist arthroscopy and open surgical repair between 2010 and 2017. Seven cases diagnosed with ECU tendinopathy had undergone open procedure for the ECU tendinopathy, as well as wrist arthroscopy in the same session. Any pathology of the triangular fibrocartilage complex (TFCC) diagnosed by wrist arthroscopy were treated simultaneously with open procedure for the ECU tendinopathy. The functional outcome was evaluated by comparing the preoperative and final follow-up values of range of motion (ROM), grip strength, visual analog scale (VAS) for pain, modified Mayo wrist score and quick disabilities of the arm, shoulder, and hand (DASH) score.

Results

TFCC tears were identified in four patients of which repair was performed concomitantly. The average follow-up period was 39 months (range, 25–49 months). At the final follow-up, all the outcomes including average VAS score (6.4→1), the ROM (173→192°), quick DASH score (42.5→18.2), and modified Mayo wrist score (48.6→79.3) improved significantly.

Conclusion

When treating patients with ECU tendinopathy, the possibility of TFCC combined injury should always be considered. If surgical treatment is planned, we suggest a wrist arthroscopy for more accurate diagnosis an intra-articular pathology, particularly for patients whose MRI findings suggest a degenerative tear or degeneration at the periphery of the TFCC. Additionally, if ECU and DRUJ stability is obtained by repair or reconstruction of the concurrent pathologies in the ECU subsheath, TFCC and other intra-articular structures, the results will be favorable.
Chronic Eosinophilic Pneumonia Masquerading as a Lung Mass
Authors: Amoda Oluyemisi , Alexander Elmarie , Abowali Hesham , Uwagbale Ese , Zaman Mohammed
Published: January 2022

Lung masses are becoming more common, and although most are tumors, benign or malignant, some are not solid masses. Many pathologies can present as lung nodules, including lung cancers, hamartomas, lung abscesses, granulomas, and eosinophilic pneumonia, to name a few. A 40-year-old woman with a long history of smoking presented with cough and left-sided chest pain. After multiple imaging studies, she was thought to have a lung malignancy; however, multiple biopsies proved this was not the case. The histology reports of 3 to 4 biopsies at separate times indicated chronic inflammation ongoing in the lungs without any cancer cells present. She was treated for chronic eosinophilic pneumonia with a resolution of symptoms. The purpose of this case report is to discuss a case that was initially thought to be a lung mass but found to be chronic eosinophilic pneumonia manifesting as a lung mass.
Sepiolite as an efficient adsorbent for ethylene gas
Authors: Erdoğan Burcu , Esenli Fahri
Published: January 2022

The ability of Na+-, Li+-, K+-, Ca2+- and Mg2+-exchanged sepiolites and acid-activated sepiolites to remove ethylene from storage environments was examined. The sepiolite from Sivrihisar deposit, Turkey, was treated with 1.0 M NaNO3, LiNO3, KNO3, Ca(NO3)2, Mg(NO3)2, HNO3 and H2SO4 solutions at 90°C for 4 h. The mineralogical, chemical and textural properties of the materials were examined using X-ray diffraction, X-ray fluorescence, cation-exchange capacity and nitrogen gas adsorption analyses. The main mineral phase present in the materials was sepiolite, with minor dolomite, and traces of quartz and feldspar minerals and amorphous matter. Adsorption isotherms of ethylene at 273 K were measured on sepiolite samples over a pressure range of 0–100 kPa. As a result of partial blockage of the sepiolite channels, the ethylene adsorption capacity on cation-exchanged sepiolite forms (0.376–0.907 mmol g–1) was less than that of acid-activated sepiolite forms (1.279 and 1.308 mmol g–1). The ethylene adsorption capacities of the sepiolite samples were compared with those of other clay-based materials (0.167–1.817 mmol g–1) reported in previous studies of ethylene removal.