bluuebunny/crossref_metadata_2025 huggingface dataset:
Место административной ответственности в системе публично-правовой ответственности
Authors: Руденко А.В.
Published: April 2023

В статье рассматривается вопрос содержания понятия публично-правовая ответственность, его структуры и соотношения с другими видами ответственности. В работе анализируются мнения ученых и правовые позиции Конституционного суда Российской Федерации.
Особенности осуществления отдельных видов государственного контроля за предпринимательской деятельностью (на примере государственного лицензионного контроля)
Authors: Сафонова С.А.
Published: April 2023

В рамках данной статьи исследованы нормативно-правовые основы осуществления государственного лицензионного контроля за предпринимательской деятельностью, на основе которых определены особенности соответствующего направления государственной контрольной деятельности. По результатам проведенного исследования сделан вывод о том, что к числу особенностей государственного лицензионного контроля могут быть отмечены следующие: наличие самостоятельной нормативно-правовой базы, ее разрозненность, наличие особого объекта и предмета государственного лицензионного контроля, а также использование специфичных мер юридической ответственности, выражающихся в приостановлении, прекращении либо аннулировании лицензии.
«Врачебная ошибка» глазами пациентов и студентов медицинского университета
Authors: Симонян Р.З. , Некрасов А.А.
Published: April 2023

В последние годы продолжает оставаться актуальной проблема «врачебных ошибок». Всё чаще среди медицинских работников и юристов, в средствах массовой информации и российском обществе в целом, поднимается эта сложнейшая и вместе с тем исключительно важная тема. Резонанс ей придаёт растущее с каждым годом число обращений пациентов, направленных в Следственный комитет Российской Федерации.
Проблема дискриминации в трудовом праве
Authors: Сороколетова М.А. , Золотарева В.А.
Published: April 2023

Данная статья посвящена одной из распространенных проблем в сфере трудовых отношений – дискриминации. Рассматриваются причины возникновения дискриминации, а также их виды. В статье приводится и раскрывается перечень наиболее распространенных видов дискриминации в сфере труда, анализируется судебная практика, посвященная данной теме.
Защита персональных данных работника
Authors: Сороколетова М.А. , Лесовский Ю.Ю.
Published: April 2023

Данное научное исследование предполагает анализ законодательства о способах защиты персональных данных работников. В научной работе учитываются законодательные акты, которые применяются для выполнения механизма защиты данных, личной информации. Также исследуется порядок защиты и анализ эффективности мероприятий по обеспечению персональных данных.
Проблемы реализации права на забастовку в Российской Федерации
Authors: Сороколетова М.А. , Нестеренко В.В.
Published: April 2023

Право на забастовку является одним из важных конституционных и трудовых прав. Несмотря на правовую регламентацию реализации процедуры забастовки, на практике возникают определенные трудности, которые снижают ее эффективность. В настоящей статье авторами рассматриваются актуальные проблемы реализации права на забастовку в Российской Федерации и предлагаются возможные пути их разрешения.
Понятие, признаки и особенности применения специальной дисциплинарной ответственности
Authors: Сороколетова М.А. , Пантюхина Е.А.
Published: April 2023

В данной работе рассматриваются понятие специальной дисциплинарной ответственности, а также основные критерии, которые отличают ее от общей дисциплинарной ответственности.
Современные проблемы регулирования земельных отношений в РФ
Authors: Федорченко Н.Д.
Published: April 2023

В статье определены проблемы в механизмах регулирования земельных отношений. Данный правовой институт является традиционным в системе российского земельного права, однако в последнее время он претерпел существенные изменения и приобрел особое значение. Особое внимание уделено изменению законодательства в 2020 году. Автор отметил, что выявленные вопросы не являются полным перечнем существующих на сегодняшний день проблем, связанных с механизмом регулирования земельных отношений. Этот перечень можно еще больше расширить, выделяя как причины, так и следствия этих проблем, причем особое внимание следует уделить путям решения этих проблем.
Идеология в России: история и современность
Authors: Юнцев М.А.
Published: April 2023

Идеология России очень дискуссионная тема, как минимум потому, что наша страна совсем недавно была государством с установленной политической доктриной, интерес к этой теме начинает возрастать с каждым годом. В данной статье проанализирована история государственных идеологий России и других государств, была проведена оценка их влияния на страны. Зарубежный опыт изучен с точки зрения, применения его в России. На основе исследования были выведены критерии содержания возможной политической доктрины государства.
Техногенные аварии как элемент техносферной безопасности
Authors: Томшин Е.А. , Старых А.А. , Любская О.Г.
Published: April 2023

Темп научно-технической трансформации жизни сегодня экстраординарно высок. Человеческое общество перешло в новое состояние – состояние могущества, для которого характерно резкое возрастание скорости создания новых технологий, многократное увеличение темпов развития производительных сил и появления новых научных открытий. В современном мире техногенные аварии создают чрезвычайные ситуации, последствия которых по своим масштабам оказывают влияние на весь мирохозяйственный порядок, имеют транснациональный характер. Следовательно, научно-техническое и технологическое развитие, приводящие к возможности возникновения, и профилактика техногенных аварий, являясь актуальной темой сегодня, требует дальнейшего изучения.
Сравнение физических качеств направленных на повышение здоровья
Authors: Желтов А.А. , Колесниченко Т.В. , Усова А.Н.
Published: April 2023

В данной статье рассматривается польза физической нагрузки направленной на повышение силы и выносливости, а также ведется сравнение данных физических качеств, влияющих на здоровье человека.
Роль физической культуры для студентов, обучающихся в Высших учебных заведениях
Authors: Матвеева А.А.
Published: April 2023

В данной статье рассматриваются вопросы связанные с ролью спортивного образа жизни студента. Важности его для развития личностных качеств, отличной успеваемости не только в учѐбе, но и в повседневной жизни. Говорится также и о здоровье, здоровом образе жизни, которые являются важными показателями современной жизни и которые, несомненно, связаны с физической культурой и спортом, так как спорт, являясь составной частью культуры, представляет собой кладезь навыков, знаний и умений, которыми пользуются люди для того, чтобы достичь высоких целей и добиться интеллектуального развития.
Психология и печать отличия героев романа Германа Гессе «Демиан»
Authors: Абубакаров А.Х. , Дикаева Р.М. , Дикаева Х.М.
Published: April 2023

Данная статья исследует психологию главных героев романа Германа Гессе «Демиан» и прослеживает мотив их поведения. Также в работе раскрывается смысл печати Каина, о которой говорится в произведении, и объясняется символ этого явления, которым отмечены герои, как знаком избранности и одиночества на пути познания себя.
Связь созависимости с копинг-стратегиями у работающих и безработных женщин
Authors: Гребенюк В.И.
Published: April 2023

В статье приводится анализ современных взглядов на особенности копинг-стратегий во взаимосвязи с созависимостью у работающих и неработающих женщин. В качестве исследовательской задачи автором была произведена определить наличие взаимосвязи между совладающим поведением и эмоциональной зависимостью. В статье приводятся результаты исследования, которые могут быть использованы при разработке программ в сфере трудовой занятости у женщин.
Об аддиктивном потенциале беременности
Authors: Магсаржав Ц.
Published: April 2023

Все аспекты беременности, если взглянуть на них с философских и психологических сторон, очень обширны и, в связи с этим, противоречивы. Цель данной статьи - исследовать, можно ли при определенных обстоятельствах рассматривать беременность как аддикцию. Рассмотрены роли статистических данных, нарциссизма, стиля переживания беременности, мотивации при аддикциях и в рамках планирования беременности, возможные пути психокоррекционных и психотерапевтических вмешательств. В условной половине случаев беременность имеет в своем течении аддиктивноподобные для личности переживания. Сомнителен феномен беременности как аддикции.
Закон об образовании 1944 года и его роль в становлении британской сферы образования
Authors: Явнова И.И.v
Published: April 2023

В статье рассматривается процесс разработки закона об образовании 1944 года. Анализируются ключевые изменения образовательной системы, которые были осуществлены председателем совета по образованию Ричардом Батлером. Показаны результаты применения данного законодательного акта для последующей динамики развития британского общества.
Философско – культурологический аспект театрального пространства
Authors: Афанасьева Т.Ю.
Published: April 2023

Проблема выхода театральной деятельности в философско – культурологическое пространство вызывает значительный интерес широкого круга исследователей в области театрального искусства. Вопрос о предназначении театра в театральной культуре не раз поднимался учеными XX века, но его детального решения так и не было принято. В самом деле, неразумно было бы оспаривать ту очевидность, что конструирование реальности в театральном творчестве напрямую связано с непосредственным участием человека, что коренным образом отличает театральное искусство от других видов искусства. И нет ничего удивительного в том, что термин «театральное пространство» повлиял на художественные формы реальности в театре. В статье с позиций философии и культурологии анализируется специфика концепта «театр», влияние театрального пространства на человека и на общество. Автор делает попытку проследить переход театрального пространства в вектор культурно – философского дискурса. Актуальность выбора темы исследования обусловлена, прежде всего, широкого круга интересов в сферах культурологии и философии. Ученые в области культурно – философских аспектов уже немало лет занимаются исследованием культурного пространства, однако детального анализа театрального пространства в рамках культурологии и философии не посвящалось.
Музыкально-сценическое творчество Г.Г. Вдовина
Authors: Гулая Т.Н.
Published: April 2023

В статье рассматриваются музыкально-сценические произведения композитора Мордовии, аспекты интерпретации литературных первоисточников национальной драматургии, обусловленность музыкально-выразительных средств мордовским национальным мелосом.
COMMISSIONER IN CASES OF THE EUROPEAN COURT OF HUMAN RIGHTS AS A PUBLIC SERVICE SUBJECT
Authors: Balamush M. A. , Lazarieva M. I.
Published: April 2023

The article defines and substantiates the legal statu of the Commissioner in the cases of the European Court of Human Rights according to the criteria and classifications presented in scientific sources. It has been established that the system of public positions, whose activities are aimed at ensuring and realizing the rights and freedoms of man and citizen in Ukraine, has not yet received a comprehensive and comprehensive study. Most institutes in this field work separately and unconsolidated. It was found that the rapid development of national legislation in the field of public service demonstrates, on the one hand, the European integration aspirations of our state to create an effective system of managers who solve problems both at the national and municipal levels, and on the other hand, the desire to consolidate all European innovations in the national legislation and the public service of Ukraine without any scientific (systemic) justification of their place and role in the already existing national system of public power. The analysis of the provisions of the current legislation on public service and scientific sources, which are devoted to the types of public service and the status of public servants in the system of executive authorities, made it possible to conclude that the position of Commissioner for the cases of the European Court of Human Rights belongs to political positions in the system of executive authorities. This is caused by the following factors: 1) the legal status of the Commissioner in the cases of the European Court of Human Rights does not correspond to the characteristics and requirements that are inherent and put forward to civil servants, persons in the patronage service and professional service; 2) the legislator has repeatedly equated the status of the European Court of Human Rights Commissioner with the status of the Deputy Minister of Justice of Ukraine, who is recognized by the Law of Ukraine “On Central Bodies of Executive Power” as a political employee in the system of bodies of executive power. It is proposed to enshrine the following definition in the national legislation: “The European Court of Human Rights Commissioner is a person who holds a political position in the Ministry of Justice, who is entrusted with the authority to represent Ukraine in the European Court of Human Rights during the consideration and resolution of cases of violations of the Convention on the protection of human rights and fundamental freedoms, on the coordination of the implementation of decisions of the European Court of Human Rights and on informing the Committee of Ministers of the Council of Europe about the progress of its implementation”.
THE SIGNIFICANCE OF THE ADMINISTRATIVE ACT AS A FORM OF ADMINISTRATIVE ACTION IN GERMAN ADMINISTRATIVE LAW
Authors: Lewandowski Alexander
Published: April 2023

The article is devoted to the consideration of administrative act as a form of management by German authorities. A special place in the article is given to the history of the act’s development into an independent unit of administrative law. The author shows the necessity of transition from the concept that emerged in the academic literature in the image of the French act administrative unilateral to a full-ledged legal figure which is still the main element of the guarantee of protection of citizens. The author examines the place of an administrative act in the system of the Administrative Procedure Act and other legal provisions of German law, with an emphasis on the difference in the understanding of an act in different branches of administrative law. The author also reveals the interaction of the act as an element of administrative coercion with the principles of democracy. Particular attention is paid to the understanding of an administrative act in the context of administrative process, including the contrast between the influence of judicial practice and its purely managerial understanding. The article also discusses the peculiarity of an administrative act, namely, its ability to be transformed depending on  the needs of public authorities and the absence of any strict restrictions on the part of the legislator. The author also raises the issue of the possibility of replacing or transforming the act with other forms of governance. The author discusses the possibility of a more detailed stratification of an administrative act to increase its effectiveness of application by making its elements easier to construct and facilitating the search for answers to emerging questions.
LAW OBJECTIVES AND GOALS OF THE ADMINISTRATIVE LAW OF UKRAINE
Authors: Mykolenko O. I. , Dobrovolskaya N. V.
Published: April 2023

The article defines the goals of administrative law and describes them. It has been established that goal setting as a method of researching legal phenomena helps, firstly, to find out the orientations of legal regulation of law and its elements (branches, legal institutions, legal norms), and secondly, to determine the effectiveness of legal regulation, comparing with each other goals and results of legal regulation. At the same time, law is a multi-level system in which each level has its own specific set of goals determined by the subject of legal regulation. Established, goal setting helps to reveal the interdependence of the goals of legal regulation and the results of legal implementation. It was found that in scientific sources, administrative law was studied as an element of the legal system of Ukraine, as a systemic phenomenon, as a functional legal phenomenon, however, there are almost no publications dedicated to the goals of administrative law and its elements. In view of this, the study of goal setting in law and the goal of administrative law is considered relevant for the development of legal doctrine in Ukraine. It is proven that administrative law, as a branch of Ukrainian law, pursues the following basic goals: regulation of social relations, which are determined by the object and subject of administrative-legal regulation; protection of administrative legal relations and legal relations of other branches of Ukrainian law; consolidation of administrative proceedings regarding the implementation of material norms of administrative law. It was concluded that administrative law, as a branch of public law, has the following goals: consolidation of the mechanism of building a system of public administration bodies and the foundations of its functioning, the main duty of which is to affirm and ensure human rights and freedoms; establishment of legal standards for the organization of public service, which contribute to ensuring and realizing the rights and freedoms of a person and a citizen; establishment of legal standards for implementation of management procedures and management activities; establishment of legal standards for the implementation of law-making procedures regarding the issuance by subjects of public administration of bylaws; establishment of legal standards for the implementation of administrative procedures and public service activities; establishment of legal standards for the implementation of control activities by subjects of public administration; establishment of legal standards for law enforcement activities of public administration entities; establishment of methods and mechanisms of administrative-legal protection of violated rights and freedoms of a person in the public-legal sphere.
STUDYING UKRAINIAN CIVIL PROCEDURE LAW IN THE EARLY 3 d MILLENNIUM
Authors: Cherneha V. M.
Published: April 2023

The article is dedicated to the gains, problems, and perspectives of studying the Ukrainian civil procedure law. It covers polythematic studies of the Ukrainian civil procedure law presented in dissertations.
Despite the updates to the civil procedure laws of Ukraine, not all the civil procedure regulations and institutions (sources of the civil procedure law, evaluation categories in civil procedure law, civil jurisdiction, entities subject to civil procedure law, electronic evidence, legal expert’s opinions, measures of procedural compulsion, specifics of considering and settling civil cases of certain categories through the appeal and cassation procedure, specifics of considering by court the claims for imposing restrictions on an individual for gambling and attending gambling events, specifics of considering by court the claims for issuing and prolonging a restrictive injunction, judicial control of the execution of civil judgements, resuming the lost proceedings by court) were the subject of the scientific research; many of them require a systematic analysis to be carried out by experts.
The article states that the Ukrainian civil procedure studies lack the comparative legal research including the Ukrainian and foreign practices (first of all, those existing in the European Union and the Organization for Economic Co-operation and Development, the Great Britain, the United States of America).
The next pieces of research may focus on how the scientific thought is and will be developing in terms of the notarial and enforcement law and process.
It is worth specifying the past, present, and future of the legal studies dedicated to the alternative forms of settling civil disputes.
THE ISSUE OF «TRIAGE» IN GERMAN CRIMINAL LAW
Authors: Heinrich Bernd
Published: April 2023

The article deals with the issue of “triage” through the prism of the legal concept of the “justifying conflict of duties», which has triggered considerable debate in Germany in particular with regard to the Covid pandemic. Attention is brought to problems associated with criteria, on the basis of which a physician has to give priority to saving certain patients; the question is raised whether the legislator should establish such a “ranking” of criteria to which the physician must adhere or whether the physician should be left free to decide whom to save. It is also discussed whether the physician can be held criminally responsible for the death of the other patient. An overview of the legal assessment of the three forms of triage in Germany is given. The author also addresses the question of the legal consequences for the physician if he makes a decision for improper motives.
Conflicting Rules in Matters Relating to Maintenance Obligations where the Connecting Factor is the Will of the Parties under Articles 7 and 8 of the Hague Protocol of 23 November 2007 on the Law Applicable to Maintenance Obligations
Authors: Anitei Nadia-Cerasela
Published: April 2023

Article 2.612 of the Civil Code provides: "The law applicable to the maintenance obligation shall be determined in accordance with the rules of European Union law."

The law governing the maintenance obligation is found in the European regulations (European Commission, 2008). 

            Romania has concluded Conventions (e.g. the Convention between Romania and the Kingdom of Belgium on the recognition and enforcement of judgments in matters relating to maintenance obligations) and Legal Assistance Treaties (Government of Romania, 1999; International Act, 1995; Parliament of Romania, 1995; 1997).

The legal framework for the application in Romania of European Union regulations and various instruments of private international law in the field of maintenance obligations is Law No 36/2012 on certain measures necessary for the implementation of certain regulations and decisions of the Council of the European Union (2009) and instruments of private international law in the field of maintenance obligations (Parliament of Romania, 2012).

Among the European regulations in this field, we have proposed to dedicate our study to the Hague Protocol of 23 November 2007 on the law applicable to maintenance obligations.

The Protocol comprises two categories of rules which differ in the nature of the point of connection:

- The first category is made up of rules which provide an objective location of the obligatory relationship (Art. 3 - Art. 6);

- The second category consists of rules whose point of connection is the will of the parties (Art. 7 to Art. 8).

This article is devoted to the presentation of the law applicable to maintenance obligations in the case of conflicting rules whose point of connection is the will of the parties as provided for in Articles 7 and 8 of the Hague Protocol of 23 November 2007 on the law applicable to maintenance obligations.
About Limits in Exercising the Active Role of the Judge in Romanian Procedural Law
Authors: Lupu Mihai
Published: April 2023

The active role of the judge, a fundamental principle of procedural law, is applied as varied as the personalities of the judges who administer justice are different.

In relatively simple lawsuits, with a well-defined object and placed in a single demand end, the active role is limited to following a natural, predictable path. However, there are also situations in which the lawsuits have a complex object, with several claims, an object that does not, in fact, resolve the dispute, but will probably lead to another lawsuit.

The tendency to emphasize formalism raises the issue of the ever-increasing limitation of the judge's role.

In this paper I propose to outline some of these boundaries and possible situations in which the judge, exercising his active role by possibly expanding the procedural framework, resolves the dispute and prevents a new trial.
The Cult of the Saints in Late Antiquity from Peter Brown’s Perspective
Authors: Enache George
Published: April 2023

In this article, the great historian Peter Brown's conception of the origins and development of the cult of saints in Late Antiquity is presented. Peter Brown's contribution to defining the concept of "Late Antiquity" is also highlighted.
General Management Components Involved in the Management of Financial Audit and Control
Authors: Tavala Florina-Maria
Published: April 2023

The efficient functioning of organizations cannot be achieved without ensuring the correct use of the public or

private funds that are at their disposal, in accordance with the objectives which they have set for themselves. Managers have the task of managing the funds in accordance with the legislation in force, as well as taking measures in order to prevent, sanction or recover any damage caused by financial irregularities or by the failure to achieve the objectives for which they were allocated.

A basic concept in the theory and practice of modern management is represented by responsibility. To fulfill his

responsibility/responsibilities, the manager needs a system of guidance, self-regulation or coercion, and that system is represented by control. Control, and in particular the financial audit and control, contributes to the evaluation of the programs performance, to the planning of activities and to a good management of resources. The successful accomplishment of these tasks cannot be accomplished outside of management science and the reverberations it entails.

The role and importance of the financial audit and control in management, imposes, as it is shown in this approach, the

need for a management of this activity, which would have its own structural elements, with specific relationships between them, and also with the system in which it evolves.

The financial audit and control management, as a segment of management, must be defined starting from the general

management. That is why, in this paper, I tried to approach, as a personal contribution, the management and financial audit in terms of general components (Management Science, Scientific Management, Management Processes, Management Relations, Management Principles, Management as a synthetic economic discipline) and in terms of the components of the organization's Management system (Information system, Decision system, Organizational system, Methodological system). The study that took place revealed a series of predictable influences such as: the need to create some computerized infrastructures, to create some horizontal information networks that would allow the efficient use of knowledge, increasing the role of management by objectives coupled with management through budgets, elaborating complex analysis and evaluation methodologies.
Pomen medsebojnega zaupanja in timskega dela v športu
Authors: Civić Aila , Vukovič Goran , Marič Miha
Published: April 2023

Teamwork is the foundation that sustains society as a whole. Among other things, this is also shown in mutual trust. Precisely for this reason, teamwork is especially important in sports, where individual members in different positions must work in harmony. Success is to be expected when we establish complete mutual trust and a well-balanced team spirit among the team members. Differences between the sexes in perception also occur in sports, but they are not so pronounced. Each individual in sports needs to be treated individually in order to ensure the success of the team as a whole. In the research work, we conducted qualitative research by conducting interviews with a professional player and a top basketball player to determine their opinion on the advantages of teamwork and mutual trust in sports. We found that team-building and socializing are two effective approaches that improve team cooperation and mutual trust, so both athletes and managers in sports need to pay more attention to this.
Dostopnost do storitev na področju duševnega zdravja v času epidemije covid-19
Authors: Crnkovič Nuša , Cesar Katarina , Gabrovec Branko , Kršić Ivana , Tovornik Teja , Paveo Vesna , Ajdič Andraž , Vrdelja Mitja , Selak Špela
Published: April 2023

High levels of hospitalisations during the first year of covid-19 epidemic demanded a swift adjustment of the health system. This resulted in temporary reallocations of healthcare workers to different tasks, limiting or temporarily suspending certain health services and programs, including mental health services, despite an increase in mental health difficulties during the epidemic. The aim of the present study was to explore the level of accessibility of mental health services, in 2020, during the covid-19 epidemic and how was the accessibility of mental health services influenced by the reallocations of healthcare workers to different tasks. An online survey was forwarded to all health institutions within the Slovenian public health system that provide mental health services. The results indicated the lowest accessibility to mental health services during the spring lockdown in 2020, while at the same period the prevalence of reallocations of the healthcare workers was at its highest. Present results also show that lower accessibility to mental health services was present where the levels of reallocations of healthcare workers was high. Implications for management of mental health services in emergency situations like covid-19 epidemic are made.
Komüniteryan Düşüncede Çokkültürlülük
Authors: EROL Mehmet Kasım
Published: April 2023

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Fransız Devrimi öncesinde başlayan ve bu devrimle birlikte daha da ivme kazanarak güçlenen milliyetçilik akımlarının sonucu olarak kendine varlık bulan ulus devletlerinin çoğunlukla homojen bir toplumsal yapıdan oluşmaması bu devletlerde yönetimsel, eğitimsel, kültürel mefhumlar başta olmak üzere bir çok soruna sebebiyet vermiştir. Ortaya çıkan bu sorunlar devlet sınırları içerisinde kalınarak yeni yaklaşımlarla aşılmaya çalışılmıştır. Bu yaklaşımların bir kısmı örneğin Kanada gibi pratikte kendine yer bulmaya çalışırken bir kısmı ise şimdilik teoride mevcudiyetini korumaktadır. Her ne kadar kendisine pratikte yer verilmese de komüniteryan yaklaşım kendisine olumsuz eleştiriler yapılmasına rağmen düşünürler tarafından kaderine terkedilmeyip üzerinde çalışılmaya devam edilmiştir.
Bu çalışmadaki amacımız bir çok boyuttan ele alınabilecek komüniteryan yaklaşımda şimdilik “çokkültürlülük” kavramını biraz tartışmaktır. Bu tartışma boyunca kavramın başta etimolojik kökeni olmak üzere farklı düşünürler açısından nasıl ele alındığının izleri sürülmeye çalışılacaktır. Bunun yanı sıra komüniteryan kavramını olumsuz eleştiriye tabi tutan birkaç düşünüre de kısaca yer verilecektir. Çalışmanın son kısmında ise kavramın bizde uyandırdığı izlenimler dilimiz döndüğünce değerlendirmeye tabi tutularak bu çalışmaya son verilecektir
Comparative evaluation of the effectiveness of autological bone marrow aspirate concentrate and platelete-rich plasma injected intraosseously in the treatment of the knee osteoarthritis
Authors: Kondrashenko Vladimir V. , Malanin Dmitry A. , Sikilinda Vladimir D. , Gorbatenko Andrey I. , Demeshchenko Maxim V. , Perfilova Valentina N. , Kostyanaya Natalia O.
Published: April 2023

The aim of the study was a comparative evaluation of bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP), administered intraosseously to patients with stage IIIII knee osteoarthritis (OA) according to the Kellgren Lawrence (K-L) classification. Materials and methods: 40 patients were recruited and divided into 2 groups for the multicenter randomized study. Patients in the main group (n = 19) underwent a single intraosseous BMAC injection, and those in the comparison group (n = 21) had a similar procedure, but with the use of PRP. Treatment results were assessed at follow-up after 1, 3, 6, and 12 months using the verbal patient satisfaction scale (VSS), visual analog scale (VAS), WOMAC index (Western Ontario and MCMaster Universities osteoarthritis index), and Leken. Results: Estimated effectiveness of the application according to VSS from 1 to 6 months of observation, the opinions of patients were intercepted in the direction of BMAC (up to 65% of positive reviews) in the detection of PRP (up to 55 % of positive reviews). However, during the period of 6 to 12 months of observation we did not get significant results. Interpretation of the application of the VAS scale indicated a pronounced decrease of pain in both groups of patients. However, in the PRP group pain scores were higher. Analysis of the treatment results according to the WOMAC scale allows us to identify significant differences at all periods of observation with the prevalence of results in the BMAC group. Evaluation of the efficacy of therapy according to the Leken index indicated a more than twofold decrease in the index in the first month of observation. Subsequently, we noticed insignificant negative dynamic up to the 12th month of observation. When checking data between groups, the statistical data was significantly better in BMAC group. Conclusion. A single intraosseous injection of BMAC has an advantage at all control periods of observation in comparison with a similar injection of PRP. Both treatments do not cause serious complications.
Long-term results of revascularization of the lower extremities in patients with critical ischemia and diabetes mellitus with localization of the occlusive-stenotic process in the femoral artery
Authors: Frolov Denis V. , Mozgovoy Pavel V. , Linchenko Diana V. , Frolov Mikhail V. , Chernovolenko Andrey A. , Dyachkova Yulia A. , Obukhov Artem D.
Published: April 2023

Aim: to determine the most preferable tactics of surgical treatment of patients with critical ischemia of the lower extremities of atherosclerotic genesis and diabetes mellitus based on a comparison of the results of revascularizing interventions. Methods: The study involved 82 patients who were treated in the department of vascular surgery due to critical ischemia of the lower extremities as a result of atherosclerotic occlusive-stenotic lesion of the femoral arterial segment against the background of diabetes mellitus. After the diagnostic stage and preoperative preparation, the patients were divided into two groups depending on the nature of the intervention performed: endovasal revascularization or femoropopliteal autovenous bypass grafting above the knee joint gap. In the postoperative period, dynamic observation of patients was continued with a predominant assessment of the clinical status. Results: Clinically, circulatory decompensation requiring repeated intervention or amputation was observed in 9 (30 %) patients from the first group and in 13 (25 %) patients from the second. High amputation was performed in 2 (6.6 %) study participants from the endovasal revascularization group and 3 (5.7 %) from the open surgery group. Over the entire observation period, 2 (6.7 %) and 4 (7.8 %) patients died in the groups under consideration, respectively. No statistically significant differences were obtained for any of the studied parameters, however, repeated interventions were significantly more frequently performed in patients undergoing endovascular revascularization. Conclusion: When analyzing the advantages and disadvantages of endovascular and open surgery in patients with diabetes mellitus and critical ischemia, the first should be preferred due to the possibility of repeated repetition throughout the patients life. Particular attention should be paid to conservative therapy and assessment of clinical status in the late postoperative period.
Features of trophic processes occurring in the bone tissue after the operation of dental implantation
Authors: Losev Fyodor F. , Komlev Sergey S. , Pugachev Svyatoslav A. , Bazhutova Irina V. , Volov Nikolay V.
Published: April 2023

Relevance: A key aspect of success after dental implant surgery is obtaining reliable osseointegration of the installed dental implant. In modern literary sources, the problem of consistency of osseointegration after the installation of dental implants is quite often touched upon. A number of authors argue that the quality of osseointegration of a dental implant depends primarily on its primary stability. Long-term studies show that bone tissue permanently undergoes various resorption and recovery processes [1, 2]. Purpose to determine the effectiveness of alkaline phosphatase and collagen protein osteocalcin in oral fluid after dental implantation. Materials and methods: Clinical studies were carried out on the basis of the Clinics of the Samara State Medical University of the Ministry of Health of Russia. A total of 240 patients with a diagnosis of partial absence of teeth were operated on. All patients received dental implants. The median age was 44.2 years (24 to 62 years; 182 women and 58 men). Results and discussion: At the stage of orthopedic rehabilitation, most patients had a low index of oral hygiene, OHI-S averaged (2.63 0.27) c.u. All patients suffering from poor oral hygiene were recommended professional hygiene with the removal of soft and hard dental deposits. At the stage of dental implantation, the OHI-S and Mulleman index was (0.66 0.03) and (0.49 0.03) c.u. respectively. Conclusions: The results of the study showed that the increase in the titer of alkaline phosphatase and the collagen protein osteocalcin was statistically insignificant. The level of acid phosphatase titer in the oral fluid reaches its critical value two weeks after the dental implantation operation. Studies have shown that this indicator remains active up to six months after surgery. This indicator can be used to interpret various emerging trophic processes occurring in bone tissue after dental implantation.
Problems of adaptation of primary prosthetic patients with complete absence of teeth to removable plate prostheses
Authors: Chepuryaeva Olga S.
Published: April 2023

The prevalence of total tooth loss has not decreased over the past decade. This is one of the most common pathologies, especially among the elderly. The restoration of the functions of chewing, aesthetics and speech in the complete absence of teeth is one of the most important tasks of modern dentistry. For the treatment of complete absence of teeth, removable plate prostheses are mainly used. The problem of adaptation of patients to them remains unresolved in the treatment of removable plate prostheses. There are many different approaches to improving the adaptation of patients with complete absence of teeth to removable plate prostheses: the installation of dental implants, the use of adhesive drugs, the use of local ozone therapy of the oral mucosa, the use of new structural materials. However, all these methods do not allow us to solve the fully existing problem of adaptation. In addition, the use of adhesive drugs can cause allergies in patients. It is not always possible to install implants and perform local ozone therapy, and expensive equipment is also necessary. An analysis of the scientific literature conducted in the article on the problems of adapting patients to orthopedic dental treatment with removable plate prostheses showed that among the methods of non-drug effects on these processes, the use of biological feedback methods may be preferable, which helps to reduce the adaptation period by stimulating the human bodys own reserves.
Myoma of the rudimentary uterus in Mayer –Rokitansky – Kuster – Hauser syndrome. Clinical case
Authors: Selikhova Marina S. , Sviridova Natalia I. , Yakhontova Maria A. , Maksimov Sergey N.
Published: April 2023

The article presents a clinical case of large fibroids with complete aplasia of the uterus and vagina (Mayer Rokitansky Kuster Hauser syndrome), a retrospective analysis of the patients anamnestic data, the result of surgical treatment.
A clinical case of postinfaction aneurysm development, in a patient after COVID-19
Authors: Petrova Olga V. , Tverdokhlebova Diana K. , Shabanova Galiya R. , Nikulina Dina M. , Shashin Sergey A.
Published: April 2023

There is no data in the literature on the course of myocardial infarction in patients after COVID-19. Purpose to use a clinical example to present a case of postinfarction left ventricular aneurysm in a patient after undergoing COVID-19. Materials and methods: Patient T., 49 years old, was admitted to the federal state budgetary institution Federal Center of Cardiovascular Surgery of the Ministry of Health of the Russian Federation (Astrakhan) with complaints of pain in the heart with irradiation in the left shoulder and lower jaw. Considers himself ill for 7 days. It is known from anamnesis of life that the patient suffered COVID-19 two weeks ago. He has been suffering from arterial hypertension for a year. Results: A clinical example demonstrates that COVID-19 affects course of myocardial infarction: it is a risk factor for the development of post infarction aneurysm of the left ventricle in the early stages after a myocardial infarction. Myocardial infarction was accompanied by the formation of pathological Q waves, impaired conduction of the right leg of the Gis bundle a decrease in the ejection fraction of the left ventricle, acute occlusion of the right coronary artery. Postinfarction aneurysm of the left ventricle had an anterior-septal apical localization. In addition, the study of highly sensitive troponin T and N-terminal fragment of the pro-brain natriuretic peptide type B in patients with myocardial infarction complicated by postinfarction aneurysm of the left ventricle after COVID-19 is also important for determining the stages of development of pathological processes in this pathology, evaluating the effectiveness of therapy and the outcome of this pathology.
Application of interval normobaric hypoxia-hyperoxia in the treatment of high myopia
Authors: Bizhoeva Liana K. , Borukaeva I. Kh. , Ivanov Anatoliy B.
Published: April 2023

The emergence of a new hypoxic therapy regimen in which hypoxic intervals alternate with hyperoxic intervals (30 % O2) led to the need to study the effectiveness of hypoxic-hyperoxic therapy for the treatment of progressive myopia. An ophthalmologic study was performed on 116 male patients from 8 to 21 years of age with severe myopia. Doppler study of cerebral vessels, determination of indices of functional respiratory system were carried out. Interval hypoxia-hyperoxia therapy proved to be an effective alternative method for improving visual function of the eye and preventing further progression of myopia as a result of improved blood supply to the central and peripheral parts of the visual analyzer.
Analysis of the quality of osseointegration of dental implants by using the Periotest M device
Authors: Komlev Sergey S. , Kapishnikov Aleksandr V. , Pugachev Svyatoslav A.
Published: April 2023

The main criterion for assessing the engraftment of dental implants is their high-quality osseointegration [1]. Unreasonable loads exerted on a dental implant integrated into the bone tissue lead to its premature rejection. Adequate osseointegration of dental implants is also influenced by their shape, size, quality of their installation, adherence to the operating protocol, as well as the start date of subsequent prosthetics [2]. A qualitative method for determining the stability of an installed dental implant is the method of periotestmetry. In the absence of general somatic pathologies and disorders in the structure of the dental system, stable osseointegration of dental implants, periotestometry data (averaged values for 16 strokes) are in the range from -8 to 0 units. The aim of the study was to analyze the osseointegration of installed dental intraosseous-on bone implants by performing periotestmetry. Materials and methods: The study group consisted of 116 patients who received 167 dental implants. At 1, 2, 4 months, half a year, a periotestmetric study was conducted using the Periotest M apparatus. Results and discussion: The analysis of the parameters obtained in the course of the study revealed the dependence of the periotestmetric data and the quality of osteontegration of intraosseous-extraosseous dental implants. Conclusion: The study of the indicators of periotestmetric data for intraosseous-bone dental implants made it possible to qualitatively predict the results of orthopedic treatment, and also made it possible to assess the degree of osseointegration of the installed dental implants.
MÜSTAKİM MUSTAFA NİYÂZÎ’NİN SOHBETÜ’L-GÂYE İSİMLİ ESERİNDE SAYI SEMBOLİZMİ
Authors: GÜNERTÜRK Tuğba
Published: April 2023

İnsanoğlu ilkçağlardan itibaren yaşamına dair pek çok şeyi sayma ve hesap etme isteği duymuş, bunun neticesinde de hayatında var olan nesnelere, kavramlara ve kelimelere çeşitli anlamlar vererek onlara bazı simgesel değerler yüklemiştir. Sayılara yüklenen bu farklı manalar da sayı sembolizminin ortaya çıkmasında etkili olmuştur. Türklerin İslamiyet’ten önceki bazı inanış ve ritüellerinde de var olan sayı sembolizmi İslamiyet’in kabulünden sonra da çeşitli şekillerde varlığını sürdürmeye devam etmiştir. Masal, destan ve halk anlatılarında görülen sayı simgeciliği zamanla felsefî metinlerde kullanılmaya başlanmıştır. İbn Arabî ile sistemleştirilen harf ve sayı sembolizmi sonraki dönemlerde sadece felsefî metinlerde değil tasavvufî ve edebî metinlerde de varlığını hissettirmiştir. Manzum-mensur birçok eserde sayı sembolizminin kullanımına dair örnekler bulunmaktadır. 18.yüzyılda Müstakim Mustafa Niyâzî tarafından kaleme alınmış olan Sohbetü’l-Gâye de bu eserlerden birisidir. Eser, anlatımında sembolik ifadelerin kullanıldığı tasavvufî bir metindir. Eserin tamamında anlatılanların 7, 14 ve 28 gibi yedi ve yedinin katlarına denk gelecek şekilde belli sayılara dayandırılarak izah edilmeye çalışıldığı görülmektedir. Vahdet-i vücûd düşüncesini yansıtan eserde, iç içe girmiş farklı birçok tasavvuf ıstılâhı ile kainatın yaratılışından mevsimlerin oluşumuna, gün, hafta, ay ve sene hesabından insanda var olduğu ifade edilen latîfelere, Fâtiha sûresinin yedi ayetinden kurra-i seb‘aya, Allah’ın sübûtî ve selbî sıfatlarından Arap alfabesindeki harf sayısına ve sûfînin çıktığı seyr ü süluk yolculuğuna kadar anlatılan pek çok şeyde ifade edilenler yedi ve yedinin katlarına uygun şekilde açıklanmaya çalışılmış ve eserde hep bu sayıların izi sürülmüştür. Bu çalışmada, eserde vurgulanan sayılar üzerinden sayı sembolizminin farklı düşünce sistemlerinde nasıl değerlendirildiği ele alınmış ve Sohbetü’l-Gâye’deki sayı sembolizmi örneklerle izah edilmeye çalışılmıştır.
How acute myeloid leukemia (AML) escapes from FMS-related tyrosine kinase 3 (FLT3) inhibitors? Still an overrated complication?
Authors: Perrone Salvatore , Ottone Tiziana , Zhdanovskaya Nadezda , Molica Matteo
Published: April 2023

FMS-related tyrosine kinase 3 (FLT3) mutations, present in about 25%-30% of acute myeloid leukemia (AML) patients, constitute one of the most frequently detected mutations in these patients. The binding of FLT3L to FLT3 activates the phosphatidylinositol 3-kinase (PI3K) and RAS pathways, producing increased cell proliferation and the inhibition of apoptosis. Two types of FLT3 mutations exist: FLT3-ITD and FLT3-TKD (point mutations in D835 and I836 or deletion of codon I836). A class of drugs, tyrosine-kinase inhibitors (TKI), targeting mutated FLT3, is already available with 1st and 2nd generation molecules, but only midostaurin and gilteritinib are currently approved. However, the emergence of resistance or the selection of clones not responding to FLT3 inhibitors has become an important clinical dilemma, as the duration of clinical responses is generally limited to a few months. This review analyzes the insights into mechanisms of resistance to TKI and poses a particular view on the clinical relevance of this phenomenon. Has resistance been overlooked? Indeed, FLT3 inhibitors have significantly contributed to reducing the negative impact of FLT3 mutations on the prognosis of AML patients who are no longer considered at high risk by the European LeukemiaNet (ELN) 2022. Finally, several ongoing efforts to overcome resistance to FLT3-inhibitors will be presented: new generation FLT3 inhibitors in monotherapy or combined with standard chemotherapy, hypomethylating drugs, or IDH1/2 inhibitors, Bcl2 inhibitors; novel anti-human FLT3 monoclonal antibodies (e.g., FLT3/CD3 bispecific antibodies); FLT3-CAR T-cells; CDK4/6 kinase inhibitor (e.g., palbociclib).