bluuebunny/crossref_metadata_2025 huggingface dataset:
Производительность отечественного процессора Эльбрус-8С в суперкомпьютерном моделировании задач вычислительной газовой динамики
Authors: Горобец Андрей Владимирович , Gorobets Andrei Vladimirovich , Нейман-заде Мурад Искендер оглы , Neiman-Zade Murad Iskender ogly , Окунев Сергей Константинович , Okunev Sergei Konstantinovich , Калякин Александр Алексеевич , Kalyakin Aleksandr Alekseevich , Суков Сергей Александрович , Sukov Sergei Aleksandrovich
Published: May 2019

Исследуется производительность отечественного процессора Эльбрус-8С на расчетах задач вычислительной газовой динамики. Рассматриваются параллельные программные комплексы на основе методов повышенной точности на неструктурированных сетках для численного моделирования турбулентных течений. Описаны особенности архитектуры Эльбрус, а также подходы к адаптации и оптимизации программ. Производительность исследована как для алгоритмов в целом, так и для основных составляющих алгоритмов операций в отдельности. Представлены результаты сравнительного тестирования с различными многоядерными процессорами Intel и AMD.
Математическая модель стенда для испытания акселерометров
Authors: Соколов Сергей Михайлович , Sokolov Sergei Mikhailovich , Богуславский Андрей Александрович , Boguslavsky Andrei Aleksandrovich , Трифонов Олег Всеволодович , Trifonov Oleg Vsevolodovich , Сазонов Виктор Васильевич , Sazonov Viktor Vasil'evich
Published: May 2019

Построена математическая модель стенда натурных динамических испытаний акселерометров, созданного в ИПМ им. М.В. Келдыша РАН. Стенд имеет подвижную платформу с одной степенью свободы. Платформа может вращаться вокруг неподвижной вертикальной оси. К платформе жестко крепятся тестируемые блоки акселерометров, и ей придается варьируемое в широких пределах вращение. Фактическое изменение угла поворота платформы реконструируется апостериори по видеоизображению, получаемому с помощью системы технического зрения. Реконструкция выполняется численно, что позволяет рассчитать реальные ускорения, испытываемые акселерометрами. Рассчитанные ускорения сравниваются с цифровыми данными измерений. По результатам сравнения выполняются тестирование и калибровка чувствительных элементов акселерометров, электронных блоков и т.п.
Вариационная энтропийная регуляризация разрывного метода Галеркина для уравнений газовой динамики
Authors: Криксин Юрий Анатольевич , Kriksin Yury Anatolievich , Тишкин Владимир Федорович , Tishkin Vladimir Fedorovich
Published: May 2019

Для уравнений газовой динамики построена конструктивная версия разрывного метода Галеркина произвольных порядков точности, опирающаяся на новый вариационный принцип энтропийной регуляризации, обеспечивающий выполнение дискретных аналогов законов сохранения массы, импульса, полной энергии и энтропийного неравенства.
Atiyah Classes of Strongly Homotopy Lie Pairs
Authors: Chen Zhuo , Lang Honglei , Xiang Maosong
Published: May 2019

The subject of this paper is strongly homotopy (SH) Lie algebras, also known as L∞-algebras. We extract an intrinsic character, the Atiyah class, which measures the nontriviality of an SH Lie algebra A when it is extended to L. In fact, with such an SH Lie pair (L, A) and any A-module E, there is associated a canonical cohomology class, the Atiyah class [αE], which generalizes the earlier known Atiyah classes out of Lie algebra pairs. We show that the Atiyah class [αL/A] induces a graded Lie algebra structure on [Formula: see text], and the Atiyah class [αE] of any A-module E induces a Lie algebra module structure on [Formula: see text]. Moreover, Atiyah classes are invariant under gauge equivalent A-compatible infinitesimal deformations of L.
Reframing Assistive Robots to Promote Successful Aging
Authors: Lee Hee Rin , Riek Laurel D.
Published: May 2019

We are living in an exciting time, as people are living longer, more active lives. This is reshaping how we think about aging. Rather than viewing aging as a problem to be fixed (i.e., a deficit model of aging), many aging researchers are viewing aging as a developmental stage of life to be celebrated and supported, that is, “successful aging.” In this article, we embrace this approach and consider it in the context of assistive robot design in an aim to steer the conversation away from deficit models that have limited robot design possibilities. To explore an alternative design approach to the study of aging in human-robot interaction (HRI), we invited five aging researchers (three geriatricians, one gerontologist, and one epidemiologist) and nine older adults to participate in our research. In the study, participants illustrated their interpretations of aging and suggested potential assistive robots. We found that while all participants perceived the importance of potential disabilities due to aging, they considered potential disabilities as only one aspect of the experience of aging. They highlighted other key themes to consider in designing robots to support successful aging, such as older adults’ autonomy and resilience. We discuss these findings for the HRI community and call for “robots for successful aging.”
Communicating Dominance in a Nonanthropomorphic Robot Using Locomotion
Authors: Li Jamy , Cuadra Andrea , Mok Brian , Reeves Byron , Kaye Jofish , Ju Wendy
Published: May 2019

Dominance is a key aspect of interpersonal relationships. To what extent do nonverbal indicators related to dominance status translate to a nonanthropomorphic robot? An experiment (
N
= 25) addressed whether a mobile robot's motion style can influence people's perceptions of its status. Using concepts from improv theater literature, we developed two motion styles across three scenarios (robot makes lateral motions, approaches, and departs) to communicate a robot's dominance status through nonverbal expression. In agreement with the literature, participants described a motion style that was fast, in the foreground, and more animated as
higher status
than a motion style that was slow, in the periphery, and less animated. Participants used fewer negative emotion words to describe the robot with the purportedly high-status movements versus the purportedly low-status movements, but used more negative emotion words to describe the robot when it made departing motions that occurred in the same style. This result provides evidence that guidelines from improvisational theater for using nonverbal expression to perform interpersonal status can be applied to influence perception of a nonanthropomorphic robot's status, thus suggesting that useful models for more complicated behaviors might similarly be derived from performance literature and theory.
Ghrelin in rat pancreatic islets decreases islet blood flow
Authors: Drott Carl Johan , Franzén Petra , Carlsson Per-Ola
Published: May 2019

The peptide ghrelin is mainly produced in some of the epithelial cells in the stomach, but also, during starvation, by the ε-cells in the endocrine pancreas. Ghrelin, as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R1α), exerts a variety of metabolic functions including stimulation of appetite and weight gain. Its complete role is not yet fully understood, including whether it has any vascular functions. The present study evaluated if ghrelin affects pancreatic and islet blood flow. Ghrelin and the GHS-R1α receptor antagonist GHRP-6 were injected intravenously in rats followed by blood flow measurements using a microsphere technique. Ghrelin decreased, while GHRP-6 in fasted, but not fed, rats selectively increased islet blood flow fourfold. GHS-R1α was identified not only on glucagon-producing cells but also seemed to be present in the islet arterioles. GHRP-6 in fasted rats, only, also improved the peak insulin response to glucose in vivo, thereby substantially blunting the hyperglycemia. GHRP-6 doubled glucose-stimulated insulin release in vitro of both islets obtained from fed and fasted rats. Our results indicate a novel role for endogenous ghrelin acting directly or indirectly as a local vasoconstrictor in the islets during fasting, thereby restricting the insulin response to hyperglycemia. This is to the best of our knowledge the first report that shows this physiological mechanism to restrict insulin delivery from the islets by acting on the vasculature; a mode of action that can be envisaged to complement the previously well-described mechanisms of ghrelin acting directly on the islet endocrine cells.
Experience with Balloon Dilatation in Crohn’s and Non-Crohn’s Benign Small-Bowel Strictures: Is There a Difference?
Authors: Tsuboi Akiyoshi , Oka Shiro , Tanaka Shinji , Iio Sumio , Otani Ichiro , Kunihara Sayoko , Hayashi Ryohei , Chayama Kazuaki
Published: May 2019

Background/Aim. Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn’s disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel strictures in non-CD patients compared with CD patients. Methods. Ninety-eight consecutive patients (mean age, 53 years; average observation period, 45 months) with small-bowel strictures diagnosed by double-balloon endoscopy were retrospectively evaluated at Hiroshima University Hospital from August 2003 to April 2017. The average number of procedures, short-term and long-term EBD success rates, and safety profiles between the non-CD and CD groups were examined. Results. Surgery was selected as the initial treatment in 44 cases (45%) (non-CD group, 27 (61%); CD group, 17 (39%)) as EBD is not indicated. Fourteen non-CD patients had strictures due to malignant tumors, while 13 patients had benign strictures. Twenty-three patients (non-CD, 12; CD, 11) underwent EBD. Forty-three EBD procedures were performed for 17 stricture sites (average: 2.5 procedures/site) in non-CD patients and 41 EBD procedures for 18 stricture sites (average: 2.3 procedures/site) in CD patients. The short-term success rate was 100% (23/23), whereas the long-term success rate was 92% (11/12) in non-CD patients and 82% (9/11) in CD patients. No significant differences in the surgery-free rate occurred between both groups. Furthermore, one adverse event, bleeding after EBD, was encountered in the non-CD group (8%, 1/12). Conclusion. EBD for small-bowel strictures demonstrated good clinical outcomes in non-CD patients.
Study on the Potential Biomarkers of Maternal Urine Metabolomics for Fetus with Congenital Heart Diseases Based on Modified Gas Chromatograph-Mass Spectrometer
Authors: Xie Donghua , Luo Yingchun , Xiong Xiyue , Lou Mingxing , Liu Zhiyu , Wang Aihua , Xiong Lili , Kong Fanjuan , Wang Yichao , Wang Hua
Published: May 2019

Background.There has been significant research on the genetic and environmental factors of congenital heart defects (CHDs), but few causes of teratogenicity, especially teratogenic mechanisms, can be clearly identified. Metabolomics has a potential advantage in researching the relationship between external factors and CHD.Objective.To find and identify the urinary potential biomarkers of pregnancy (including in the second and third trimesters) for fetuses with CHD based on modified gas chromatograph-mass spectrometer (GC-MS), which could reveal the possibility of high-risk factors for CHD and lay the foundation for early intervention, treatment, and prevention.Methods.Using a case-control design, we measured the urinary potential biomarkers of maternal urine metabolomics based on GC-MS in a population-based sample of women whose infants were diagnosed with CHD (70 case subjects) or were healthy (70 control subjects). SIMCA-P 13.0 software, principal component analysis (PCA), orthogonal partial least squares-discriminant analysis (OPLS-DA), Wilcoxon-Mann-Whitney test, and logistics regression were used to find significant potential biomarkers.Result.The 3D score graph of the OPLS-DA showed that the CHD and control groups were fully separated. The fitting parameters were R2x=0.78 and R2y=0.69, and the forecast rate was Q2=0.61, indicating a high forecast ability. According to the ranking of VIPs from the OPLS-DA models, we found 34 potential metabolic markers with a VIP > 1, and after two pairwise rank sum tests, we found 20 significant potential biomarkers, which were further used in multifactor logistic regressions. Significant substances, including 4-hydroxybenzeneacetic acid (OR=4.74, 95% CI: 1.06-21.06), 5-trimethylsilyloxy-n-valeric acid (OR=15.78, 95% CI: 2.33-106.67), propanedioic acid (OR=5.37, 95% CI: 1.87-15.45), hydracrylic acid (OR=6.23, 95% CI: 1.07-36.21), and uric acid (OR=5.23, 95% CI: 1.23-22.32), were associated with CHD.Conclusion.The major potential biomarkers in maternal urine associated with CHD were 4-hydroxybenzeneacetic acid, 5-trimethylsilyloxy-n-valeric acid, propanedioic acid, hydracrylic acid, and uric acid, respectively. These results indicated that the short chain fatty acids (SCFAs) and aromatic amino acid metabolism may be relevant with CHD.
Mobile Robot Path Planning Using Ant Colony Algorithm and Improved Potential Field Method
Authors: Chen Guoliang , Liu Jie
Published: May 2019

For the problem of mobile robot’s path planning under the known environment, a path planning method of mixed artificial potential field (APF) and ant colony optimization (ACO) based on grid map is proposed. First, based on the grid model, APF is improved in three ways: the attraction field, the direction of resultant force, and jumping out the infinite loop. Then, the hybrid strategy combined global updating with local updating is developed to design updating method of the ACO pheromone. The process of optimization of ACO is divided into two phases. In the prophase, the direction of the resultant force obtained by the improved APF is used as the inspired factors, which leads ant colony to move in a directional manner. In the anaphase, the inspired factors are canceled, and ant colony transition is completely based on pheromone updating, which can overcome the inertia of the ant colony and force them to explore a new and better path. Finally, some simulation experiments and mobile robot environment experiments are done. The experiment results verify that the method has stronger stability and environmental adaptability.
An Introduction to a New Space Debris Evolution Model: SOLEM
Authors: Wang Xiao-wei , Liu Jing
Published: May 2019

SOLEM is the first space debris long-term evolution model of China. This paper describes the principles, components, and workflow of the SOLEM. The effects of different mitigation measures based on SOLEM model are analyzed and presented. The limitation of the model is pointed out and its future improvement work-plan is prospected.
Novel Acaricidal Drug Fluazuron Causes Immunotoxicity via Selective Depletion of Lymphocytes T CD8
Authors: Ribeiro Juliana Gonçalves , Soares Anelise Santos , Chaves Pamella Eduardha Espindola , Limberger Jéssica Tamara , da Rosa Emanoeli , Zuravski Luísa , Oliveira Luís Flávio Souza de , Machado Michel Mansur
Published: May 2019

Fluazuron is one of the newest veterinary antitick medicines. Belonging to the benzoylphenylureas group, its mechanism of action acts by the interference of the formation of the chitin of the tick, which is responsible for the hardening of its exoskeletons. In addition to taking care of the health of the animal so that it receives the medication in the doses and the correct form, it is important to analyze the safety of the operator. Reduced resistance to infectious disease was a well-documented consequence of primary and acquired immunodeficiencies, but a novel finding following xenobiotic exposure. The awareness of the consequences of altered immune function is the most likely outcome of inadvertent exposure. The human health implications of studies in which chemical exposure reduced resistance to infection drove an early focus on immunosuppression within the toxicology community. The main objective is to perform the evaluation by computational platforms and in cell culture, searching for data that can serve as a foundation for a better understanding of the toxic effects involved with the accidental contamination of Fluazuron and, thus, to assist the medical community and users to understand the risks inherent in its use. As far as we can determine in the literature, our work has unmistakably demonstrated that the Fluazuron can cause genotoxicity by probable chromatin rearrangement and immunodepleting by specific reduction of the CD8 T lymphocyte subpopulation, mediated by the decrease in gamma interferon production. Although the use of Fluazuron is a necessity for tick control and for cattle management, we must bear in mind that the imminent risks to its application exist. Careless use can damage the immune system which in turn carries a gigantic hazard by opening a door to diseases and pathogens and leaving us defenseless.
Euglycemic Diabetic Ketoacidosis Secondary to Dapagliflozin in a Patient with Colon Malignancy
Authors: Papadokostaki Eleni , Liberopoulos Evangelos
Published: May 2019

The use of sodium-glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes is steadily increasing. SGLT2 inhibitors are associated with weight loss, lowering of blood pressure, and low hypoglycemia risk along with beneficial cardiovascular and renoprotective effects. In view of the increasing use of SGLT2i, physicians must be aware of their adverse effects. Euglycemic diabetic ketoacidosis (euDKA) is a well-recognized adverse effect of SGLT2i. We present here a case of euglycemic diabetic ketoacidosis secondary to dapagliflozin use in a type 2 diabetic patient with colon cancer. To the best of our knowledge, this is first report of SGLT2 inhibitor-associated euDKA in a patient with underlying colon cancer.
Effects of Genetic Variants of Nuclear Receptor Y on the Risk of Type 2 Diabetes Mellitus
Authors: Wang Ying , Yang Shanshan , Guan Qiuyue , Chen Jinglu , Zhang Xueping , Zhang Yuwei , Yuan Yiming , Su Zhiguang
Published: May 2019

Nuclear factor-Y (NF-Y) consists of three evolutionary conserved subunits including NF-YA, NF-YB, and NF-YC; it is a critical transcriptional regulator of lipid and glucose metabolism and adipokine biosynthesis that are associated with type 2 diabetes mellitus (T2DM) occurrence, while the impacts of genetic variants in the NF-Y gene on the risk of T2DM remain to be investigated. In the present study, we screened five single-nucleotide polymorphisms (SNPs) with the SNaPshot method in 427 patients with T2DM and 408 healthy individuals. Subsequently, we analyzed the relationships between genotypes and haplotypes constructed from these SNPs with T2DM under diverse genetic models. Furthermore, we investigated the allele effects on the quantitative metabolic traits. Of the five tagSNPs, we found that three SNPs (rs2268188, rs6918969, and rs28869187) exhibited nominal significant differences in allelic or genotypic frequency between patients with T2DM and healthy individuals. The minor alleles G, C, and C at rs2268188, rs6918969, and rs28869187, respectively, conferred a higher T2DM risk under a dominant genetic model, and the carriers of these risk alleles (either homozygotes of the minor allele or heterozygotes) had statistically higher levels of fasting plasma glucose, cholesterol, and triglycerides. Haplotype analysis showed that SNPs rs2268188, rs6918969, rs28869187, and rs35105472 formed a haplotype block, and haplotype TTAC was protective against T2DM (OR=0.76, 95% CI=0.33-0.82, P=0.004), while haplotype GCCG was associated with an elevated susceptibility to T2DM (OR=2.33, 95% CI=1.43-3.57, P=0.001). This study is the first ever observation to our knowledge that indicates the genetic variants of NF-YA might influence a Chinese Han individual’s occurrence of T2DM.
A Device Improves Signs and Symptoms of TMD
Authors: Monaco Annalisa , Pietropaoli Davide , IAPNOR  , Cooper Barry C. , Ortu Eleonora
Published: May 2019

Background. Temporomandibular joint dysfunction (TMD) therapy remains an open challenge for modern dentistry. Herein, we propose a new neuromuscular lingual device able to reduce signs and symptoms of TMD in female patients with chronic orofacial pain.Methods. 50 females with myofascial TMD according to RDC/TMD were randomly assigned to study (n = 25) and control groups (n = 25). At T0, both groups received sEMG/KNG and pain evaluation by the VAS scale. The study group received the ELIBA device (lingual elevator by Balercia) constructed under ULF-TENS (ultra-low-frequency transcoutaneous electrical nervous stimulation). Subjects were instructed to use ELIBA at least for 16 h/day. After 6 months (T1), both groups underwent to sEMG/KNG and VAS revaluation.Results. T1 study group compared to controls showed a significant reduction in total (p<0.0001) and mean (p<0.0001) sEMG values, as well as a significant increase in both maximum vertical mouth opening (p=0.003) and maximum velocity in mouth opening (p=0.003) and closing (p<0.0001). Interestingly, a significant reduction in pain measured by VAS (p<0.0001) was reported.Conclusions. After 6 months, the ELIBA device is able to significantly reduce TMD-associated myogenous pain and to promote the enhancement of sEMG/KNG values.Practical Implications. ELIBA can be considered as a new device, potentially useful for head-neck pain relief in patients suffering from chronic TMD. In addition, its use promotes a muscles relaxation inducing freeway space increase. This characteristic makes it particularly useful for rehabilitation of patients with not enough space for construction of conventional orthotics or neuromuscular bites.
Coding Region Mutation Screening in Optineurin in Chinese Normal-Tension Glaucoma Patients
Authors: He Jing Na , Lu Shiyao , Chen Li Jia , Tam Pancy Oi Sin , Zhang Bi Ning , Leung Christopher Kai Shun , Pang Chi Pui , Tham Clement Chee Yung , Chu Wai Kit
Published: May 2019

Purpose. To study the roles of sequence alterations in the optineurin (OPTN) gene-coding region in normal-tension glaucoma (NTG) among Chinese patients. Methods. Genomic DNA was extracted from 190 NTG patients and 201 control subjects. The thirteen exons of OPTN were amplified by polymerase chain reaction and analyzed by direct sequencing. Detected sequence changes were compared between NTG patients and control subjects. Results. Seven sequence changes in OPTN were identified in both NTG patients and control subjects. Among them, c.464G>A (T34 T), c.509C>T (T49T), c.806G>A (V148V), and c.959T>C (P199P) were synonymous codon changes, whilst c.655T>A (M98K), c.1996G>A (R545Q), and c.1582T>C (I407T) were missense changes. Two previously reported heterozygous mutations, c.458G>A (E50K) in exon 4 and c.691_692insAG in exon 6, were not found in this study. Out of these seven OPTN sequence variants, c.464G>A (T34T) was significantly associated with NTG in both the allelic and genotypic association analyses (allelic association: p=0.0001, OR=2.20, 95% CI: 1.46-3.31; genotypic association: p=0.0001), whereas the association of other variants with NTG did not reach statistical significance (p>0.05). Variants c.1582 T>C (I407T) and c.806G>A (V148V) were identified in one and two NTG patients, respectively, but not in the control subjects. Conclusions. This study confirmed the association of the OPTN T34T variant with NTG, suggesting that OPTN is a susceptibility gene for NTG in Chinese. Moreover, a variant with amino acid change (I407T) was identified in NTG but not in controls. Further studies are warranted to assess whether this variant is a causative mutation for NTG.
Genetic Diversity of Torch Ginger (Etlingera elatior) Germplasm Revealed by ISSR and SSR Markers
Authors: Ismail Nor Asiah , Rafii M. Y. , Mahmud T. M. M. , Hanafi M. M. , Miah Gous
Published: May 2019

Fifty-seven accessions of torch ginger (Etlingera elatior) collected from seven states in Peninsular Malaysia were evaluated for their molecular characteristics using ISSR and SSR markers to assess the pattern of genetic diversity and association among the characteristics. Diversity study through molecular characterization showed that high variability existed among the 57 torch ginger accessions. ISSR and SSR molecular markers revealed the presence of high genetic variability among the torch ginger accessions. The combination of different molecular markers offered reliable and convincing information about the genetic diversity of torch ginger germplasm. This study found that SSR marker was more informative compared to ISSR marker in determination of gene diversity, polymorphic information content (PIC), and heterozygosity in this population. SSR also revealed high ability in evaluating diversity levels, genetic structure, and relationships of torch ginger due to their codominance and rich allelic diversity. High level of genetic diversity discovered by SSR markers showed the effectiveness of this marker to detect the polymorphism in this germplasm collection.
Supplementary Light Source Affects Growth, Metabolism, and Physiology ofAdenophora triphylla(Thunb.) A.DC. Seedlings
Authors: Liu Ya , Ren Xiuxia , Jeong Byoung Ryong
Published: May 2019

Adenophora triphylla(Thunb.) A.DC., a well-known herbaceous medicinal species, has been reported to protect against human obesity, cancer, and inflammation. Supplementary lighting is a practical strategy to improve crop quality, especially at a propagation stage. However, there has been no study available on the optimal supplementary light source for the commercial production ofA. triphyllaseedlings. In this study, plug seedlings were cultivated in a greenhouse for four weeks under an average daily light intensity of 490μmol·m−2·s−1PPFD coming from the sun and a supplemental lighting (16 h per day) at 120μmol·m−2·s−1PPFD provided by high pressure sodium (HPS), metal halide (MH), far-red (FR) light, white LED (red: green: blue = 2:4:3, LED-w), or mixed (red: green: blue = 4:1:4) LED (LED-mix). The results showed that LED-mix, with a higher percentage of red and blue light, substantially promoted seedling growth compared to other treatments by increasing stem diameter, biomass, specific leaf weight, and root to shoot ratio. The LED-mix also promoted accumulation of soluble sugar, starch, and chlorophyll in the tissue and increased contents of total phenols and flavonoids. Moreover, stomata density and pore area per leaf area under the LED-mix were remarkably greater than those under other treatments. Furthermore, the Western blot analysis revealed that the expression of photosynthetic protein, D1, was notably enhanced by the LED-mix as compared with other light sources. In addition, the LED-mix alleviated the oxidative damage of seedlings by improving enzymatic and nonenzymatic antioxidant systems. Collectively, these results suggest that the LED-mix was the optimal supplementary light source for the production of highest qualityA. triphyllaseedlings.
Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γFunctional Module of Autophagy in Rheumatoid Arthritis
Authors: Wang Weiyan , Li Chunling , Zhang Zhiyi , Zhang Yue
Published: May 2019

Dysregulated autophagy leads to autoimmune diseases including rheumatoid arthritis (RA). Arsenic trioxide (ATO) is a single agent used for the treatment of acute promyelocytic leukemia and is highly promising for other malignancies but is also attractive for RA, although its relationship with autophagy remains to be further clarified and its application optimized. For the first time, we report a defective functional module of autophagy comprising the Vitamin D receptor (VDR), PPAR-γ, microtubule-associated protein 1 light-chain 3 (LC3), and p62 which appears in RA synovial fibroblasts. ATO alleviated RA symptoms by boosting effective autophagic flux through significantly downregulating p62, the inflammation and catabolism protein. Importantly, low-dose ATO synergizes with Vitamin D in RA treatment.
Oral Rehabilitation with Zygomatic Implants in a Patient with Cleft Palate
Authors: de Oliveira Guilherme José Pimentel Lopes , Brackmann Mariana Schaffer , Trojan Larissa Carvalho , Ribeiro Júnior Paulo Domingos , Padovan Luis Eduardo Marques
Published: May 2019

Edentulous patients with an atrophic maxilla associated with lip-palate fissures have unpredictable results after undergoing grafting procedures. In situations where the atrophic maxilla does not adequately allow reconstruction, the use of zygomatic implants has been indicated, and probably these implants can be indicated for the rehabilitation of patients with lip-palate fissures. This case report describes the oral rehabilitation treatment of a patient with a lip-palate cleft treated with zygomatic implants and implant-supported fixed prosthesis with two years of follow-up. A 65-year-old female patient had a lip-palate cleft and previously underwent surgery to close the cleft. The patient had a severely atrophic maxilla and had difficulty adapting to a removable total prosthesis. Due to the small amount of bone remaining and extensive fibrous tissue in the palate region, a rehabilitation with conventional implants associated with zygomatic implants was chosen. Two zygomatic implants and a conventional implant were placed on the right side, and a zygomatic implant and conventional implant were placed on the left side; these implants were later activated by a protocol-type prosthesis. The zygomatic implants provided an adequate aesthetic and functional outcome of the prosthesis in a patient with cleft palate.
Comparison of Anatomical and Visual Outcomes between Idiopathic and Myopic Macular Holes Using the Internal Limiting Membrane or Inverted Internal Limiting Membrane Flap Technique
Authors: Peralta Iturburu Federico , Garcia-Arumi Claudia , Bové Alvarez Maria , Garcia-Arumi Jose
Published: May 2019

Purpose. To compare the results of vitrectomy with those of internal limiting membrane (ILM) peeling or inverted ILM flap for treating myopic or idiopathic macular hole. Methods. Thirty-nine eyes of 39 patients undergoing vitrectomy with ILM peeling for macular hole (25 idiopathic and 14 myopic) and 27 eyes of 27 patients undergoing vitrectomy with inverted ILM flap (15 idiopathic and 12 myopic) were included. Outcome measures were macular hole closure by optical coherence tomography and visual acuity at 6 months. Results. Closure was achieved in 25 (100%) idiopathic and 12 (86%) myopic macular holes in the ILM peeling group and in 14 (93%) idiopathic and 11 (91.77%) macular holes in the inverted ILM flap group. There were no statistically significant differences in restoration of the external limiting membrane and ellipsoid zone between the groups. Median best-corrected visual acuity (logarithm of minimal angle of resolution) at the end of follow-up was 0.22 (20/32 Snellen) in idiopathic and 0.4 (20/50) in myopic (P=0.042) patients in the ILM peeling group and 0.4 (20/50) in idiopathic and 0.4 (20/50) in myopic (P=0.652) patients in the inverted ILM flap group. Conclusion. Both techniques were associated with high closure rates in myopic and idiopathic macular holes, with somewhat better visual outcomes in idiopathic cases. The small sample size may have provided insufficient power to support the superiority of one technique over the other in the two groups.
Analysis of a Cementless Femoral Stem Neck Fracture Using Scanning Electron Microscopy and the Finite Element Method
Authors: Takai Hirokazu , Nakayama Daisuke , Murayama Masatoshi , Takahashi Tomoki
Published: May 2019

Implant fracture is one of the rarest complications of total hip arthroplasty (THA). A 57-year-old woman experienced a fracture of the femoral stem (AHFIX Q, KYOCERA, Japan) about five years after THA. We examined the broken stem by digital microscopy, scanning electron microscopy, and finite element method. The anterolateral corner of the stem’s neck was found to be the origin point of the fracture. Finite element method analysis revealed that the stress concentration was highest in the corner of the hollow for apparatus attachment. The stem’s design has been considered one of the risk factors for stem fracture. In this patient, multiple risk factors, including thin stem (the smallest size, NAR #1), use of the long neck (+3 mm), obesity (body mass index: 27.3), and adjacent osteoarthritis (contralateral THA loosening and knee osteoarthritis), were present. To our knowledge, this is the first reported case of an AHFIX Q stem fracture. Surgeons must keep in mind that fracture of the femoral stem in patients with several risk factors is possible even several years after THA.
Comparative Simulation Analysis of the Performance of the Logistics Manufacturing System at the Operative Level
Authors: Bucki Robert , Suchánek Petr
Published: May 2019

The article focuses on one of the current problems of manufacturing systems which consist of individual machines equipped with dedicated tools that are replaced when they are worn out. It is assumed that the machines are located within the reach of the robotic arm which carries out transport operations of semifinished products to designated production machines and storage containers in accordance with the production time period. The aim is to find such an arrangement of production activities, respectively, production paths for a given set of orders that will be effective from the time and cost point of view. Moreover, the whole issue is solved with regard to possible failures of individual stands, overfilling of some tanks, etc. The theory and practice of creating and using simulators as tools for the definition and verification of production plans are used to solve this issue. The starting point is the creation of a mathematical simulation model with the necessary but acceptable degree of simplification. The mathematical simulation model is tested on sample data in a feasibility study to perform a detailed usability analysis of the model. The output of the article is a simulation model for which, based on the analysis of simulation results, patterns of possible use in specific types of enterprises are given.
EEHRT: Energy Efficient Technique for Handling Redundant Traffic in Zone-Based Routing for Wireless Sensor Networks
Authors: Nawaz Jadoon Rab , Zhou WuYang , Khan Iftikhar Ahmed , Khan Muhammad Amir , Jadoon Waqas
Published: May 2019

This paper presents an energy-efficient technique to handle redundant traffic (EEHRT) in the zone-based routing for wireless sensor networks. In this technique, multihop routing is performed based on the remaining energy of the nodes. Afterwards, it performs position-based routing without the need for the nodes to know their respective position. The main objective of this paper is to handle the redundant packets generated in zone-based routing using short beacon messages. Nodes of lower zones route the data of the higher zone to base station (BS) with a minimum number of hops and utilize only those nodes on the path which are energy efficient and located closer to BS. Moreover, the source node is acknowledged by the relaying node using a wireless broadcast advantage (WBA) without sending any special ACK packet to the sender, which reduces the control overhead in the routing process. The EEHRT technique improves the routing against RARZ by ensuring only one copy of the packet is propagated at each hop along the routing path to BS. Simulation results show that EEHRT achieved 28% improvement in energy efficiency, 10% and 25% improvements in data throughput against total and distinct packet reception at BS respectively, 35% increase in overall network lifetime, and 100% reduction in redundant packets generation and propagation in the network against RARZ routing.
Bootstrapping Nonparametric Prediction Intervals for Conditional Value-at-Risk with Heteroscedasticity
Authors: Torsen Emmanuel , Seknewna Lema Logamou
Published: May 2019

Using bootstrap method, we have constructed nonparametric prediction intervals for Conditional Value-at-Risk for returns that admit a heteroscedastic location-scale model where the location and scale functions are smooth, and the function of the error term is unknown and is assumed to be uncorrelated to the independent variable. The prediction interval performs well for large sample sizes and is relatively small, which is consistent with what is obtainable in the literature.
Influence of the Decelerator Grid on the Optical Performance of the Ion Thruster
Authors: Lu Chang , Zhao Yide , Wan Jie , Chu Yuchuan , Zheng Liang , Cao Yong
Published: May 2019

In order to reduce the erosion of the ion thruster accelerator grid, which is caused by charge-exchange (CEX) ions, the 2-grid optical system is added to a decelerator grid to block the reflux CEX ions. The previous experiment and simulation results have proven that the decelerator grid can effectively reduce the Pit and Groove erosion. However, the influence of the decelerator grid on the optical performance has not yet been studied well. In this paper, a three-dimensional Immersed Finite Element Method-Particle in Cell-Monte Carlo Collision (IFE-PIC-MCC) algorithm was adopted to investigate the effect of the decelerator grid on the optical performance under crossover and normal circumstances. Results show that the decelerator grid has no effect on the focusing state and the distribution of beam ions. It also has little effect on the CEX ions from the upstream and extraction (center) regions. However, it has great influence on the downstream CEX ions. When the upstream plasma number density is small, the decelerator grid will cause most of the downstream reflux CEX ions to impinge on the accelerator grid aperture barrel, resulting in the significant increase of the Barrel erosion of the accelerator grid. With the increase of the upstream plasma number density, the downstream reflux CEX ions tend to impact the downstream surface of the decelerator grid, which means the decelerator grid begins to block the downstream backflow of CEX ions.
Value of Anterior Band of the Inferior Glenohumeral Ligament Area as a Morphological Parameter of Adhesive Capsulitis
Authors: Bang Yun-Sic , Park Junbeom , Lee Sun Young , Park Jiyeon , Park Sukhee , Joo Young , Kim Young Uk , Lee Yoon Kyung
Published: May 2019

Objective. Thickened inferior glenohumeral ligament (IGHL) is considered as one of the major morphological parameters of adhesive capsulitis (AC). Previous studies reported that the anterior band of inferior glenohumeral ligament thickness (aIGHLT) is correlated with shoulder capsular contracture, luxatio erecta humeri, and AC. However, the thickness varies from the measured angle. To reduce this measurement error, we devised a new morphological parameter, called the anterior band of inferior glenohumeral ligament area (aIGHLA). Methods. The aIGHL samples were collected from 54 patients with AC and from 50 control subjects who underwent shoulder magnetic resonance imaging (MRI) without any evidence of AC. Coronal T2-weighted MRI images were obtained at the shoulder level from each patient. We measured the aIGHLA and aIGHLT at the maximal view of the IGHL in the coronal plane using our picture archiving and communication system. The aIGHLA was measured at the whole cross-sectional area of the IGHL in the most hypertrophied segment of the coronal MR images. The aIGHLT was measured at the thickest point of the IGHL. Results. The average aIGHLA was 55.58 ± 14.16 mm2 in the control group and 83.71 ± 28.45 mm2 in the AC group. The average aIGHLT was 3.47 ± 0.99 mm in the control group and 4.52 ± 1.02 mm in the AC group. AC patients showed significantly greater aIGHLA (p<0.001) and aIGHLT (p<0.001) than control subjects. Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off score of the aIGHLA was 63.37 mm2, with 79.6% sensitivity, 80.0% specificity, and AUC of 0.84 (95% CI, 0.76–0.92). The optimal cut-off point of the IGHLT was 3.81 mm, with 74.1% sensitivity, 74.0% specificity, and AUC of 0.77 (95% CI, 0.68–0.86). Conclusions. Although the aIGHLA and aIGHLT were both significantly associated with AC, the aIGHLA was a more sensitive diagnostic parameter.
Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes
Authors: Yu Weihui , Zhu Hong , Chen Xiong , Gu Xuejiang , Zhang Xingxing , Shen Feixia , Jia Weiping , Hu Cheng
Published: May 2019

Aims. Fibroblast growth factor 21 (FGF21) is closely linked with metabolic disorders including diabetes. Evidences suggested that FGF21 may play a protective role against diabetic kidney disease (DKD). However, the relationship between genetic variants in the FGF21 gene region and DKD remains unknown. In our study, we aimed to investigate the association of genetic variations in this gene region with DKD and DKD-related clinical traits. Materials and Methods. We recruited 1340 Han Chinese participants with type 2 diabetes, including 596 DKD patients and 744 patients who was diagnosed with diabetes for more than 5 years but did not progress to DKD. Three single-nucleotide polymorphisms were selected (rs2071699, rs838136, and rs499765) and genotyped. The association between these SNPs and DKD as well as DKD-related quantitative traits was analyzed. Results. We did not find any significant association between these SNPs and susceptibility to DKD in the present study. However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (β=0.013±0.006, P=0.0295, β was calculated for log10eGFR) as well as a recessive model (P=0.0385) and rs499765 was associated with eGFR under a dominant model (P=0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (β=−0.022±0.012, P=0.0820, β was calculated for log10eGFR) and showed a significant association with eGFR under a dominant model (P=0.0182). Conclusions. Our findings indicated that genetic variations adjacent to FGF21 were associated with eGFR in Chinese diabetic patients.
Methanolic Extract ofArtemia salinaEggs and Various Fractions in Different Solvents Contain Potent Compounds That Decrease Cell Viability of Colon and Skin Cancer Cell Lines and Show Antibacterial Activity againstPseudomonas aeruginosa
Authors: Islam Salman Ul , Ahmed Muhammad Bilal , Shehzad Adeeb , Lee Young Sup
Published: May 2019

Artemia salina,crustaceans of class Branchiopoda and order Anostraca, are living and reproducing only in highly saline natural lakes and in other reservoirs where sea water is evaporated to produce salt.Artemia salinaeggs can be purchased from pet stores, where they are sold as tropical fish food and a ready source for hatching shrimp. In the current study, methanolic crude extracts and various fractions ofArtemia salinaeggs extracted in other solvents were tested for effects on cell viability of human colorectal cancer cells (HCT116) and melanoma cells (B16F10) using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. A methanolic crude extract of eggs was obtained by cold maceration, followed by fractionation to obtain hexane, chloroform, ethyl acetate, n-butanol, and aqueous fractions. The methanolic crude extract decreased cell viability of HCT-116 and B16F10 cell lines at higher concentrations. The other fractions were evaluated using a cell viability assay, and chloroform and hexane showed the highest activity at significantly lower concentrations than did the methanolic fraction. Full scan profiles of the methanolic crude extract and the chloroform and hexane fractions were obtained by gas chromatography mass spectrometry (GC-MS), and the resultant compounds were identified by comparing their spectral data to those available in spectral matching libraries. ROS generation assay, flow cytometry, and western blot analysis provided supporting evidence that the hexane and chloroform fractions induced cell death in HCT116 and B16-F10 cell lines. All fractions were further tested for antibacterial activity againstPseudomonas aeruginosa, among which the hexane fraction showed the highest zone of inhibition on LB nutrient agar plates. This study demonstrated promising anticancer and antibacterial effects ofArtemia salinaegg extracts. Our results suggest that pure bioactive compounds obtained fromArtemia salinaeggs can provide new insights into the mechanisms of colon and skin cancer, as well asPseudomonas aeruginosainhibition.
Numerical Analysis of Vibration Responses in High‐Speed Railways considering Mud Pumping Defect
Authors: Li Ting , Su Qian , Shao Kang , Liu Jie
Published: May 2019

As a newly appeared defect under slab tracks in high‐speed railways, mud pumping weakens the support ability of the subgrade to slab track, bringing about deviations on the vibration responses of the vehicle, slab track, and subgrade. Therefore, this paper proposes a vehicle‐slab track‐subgrade coupled model based on the multibody simulation principle and the finite element theory to highlight the influences of mud pumping defect. As an external excitation to this model, random track irregularity is considered. In order to simulate the mud pumping defect, the contact between the concrete base and subgrade is described as a spring‐damper system. This model is validated by field test results and other simulation results, and a very good agreement is found. The vibration responses of the vehicle, slab track, and subgrade under different mud pumping lengths and train speeds are studied firstly. The deviations of vibration responses in high‐speed railways induced by mud pumping are then obtained, and the limited mud pumping length is put forward finally to provide a recommendation for maintenance works of high‐speed railways in practice.
PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness
Authors: Kaminski Lisa , Torrino Stéphanie , Dufies Maeva , Djabari Zied , Haider Romain , Roustan François-René , Jaune Emilie , Laurent Kathiane , Nottet Nicolas , Michiels Jean-François , Gesson Maeva , Rocchi Stéphane , Mazure Nathalie M. , Durand Matthieu , Tanti Jean-François , Ambrosetti Damien , Clavel Stephan , Ben-Sahra Issam , Bost Frédéric
Published: May 2019

Although tumorigenesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in the formation of metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) plays a pleiotropic role in the control of cancer cell metabolism and has been associated with a good prognosis in prostate cancer. Here, we show that PGC1α represses the metastatic properties of prostate cancer cells via modulation of the polyamine biosynthesis pathway. Mechanistically, PGC1α inhibits the expression of c-MYC and ornithine decarboxylase 1 (ODC1), the rate-limiting enzyme for polyamine synthesis. Analysis of in vivo metastases and clinical data from patients with prostate cancer support the proposition that the PGC1α/c-MYC/ODC1 axis regulates polyamine biosynthesis and prostate cancer aggressiveness. In conclusion, downregulation of PGC1α renders prostate cancer cells dependent on polyamine to promote metastasis.

Significance:

These findings show that a major regulator of mitochondrial metabolism controls polyamine synthesis and prostate cancer aggressiveness, with potential applications in therapy and identification of new biomarkers.