bluuebunny/crossref_metadata_2025 huggingface dataset:
Hearing Loss in Baraitser–Winter Syndrome: Case Reports and Review of the Literature
Authors: Ghiselli Sara , Parmeggiani Giulia , Zambonini Giulia , Cuda Domenico
Published: March 2024

Background: Baraitser–Winter Syndrome (BRWS) is a rare autosomal dominant condition associated with hearing loss (HL). In the literature, two types of this condition are reported, Baraitser–Winter type 1 (BRWS1) and type 2 (BRWS2) produced by specific pathogenetic variants of two different genes, ACTB for BRWS1 and ACTG1 for BRWS2. In addition to syndromic BRWS2, some pathogenic variants in ACTG1 are associated also to another pathologic entity, the “Autosomal dominant non-syndromic hearing loss 20/26”. In these syndromes, typical craniofacial features, sensory impairment (vision and hearing) and intellectual disabilities are frequently present. Heart anomalies, renal and gastrointestinal involvement and seizure are also common. Wide inter- and intra-familial variety in the phenotypic spectrum is reported. Some phenotypic aspects of these syndromes are not yet fully described, such as the degree and progression of HL, and better knowledge of them could be useful for correct follow-up and treatment. Methods and Results: In this study, we report two cases of children with HL and diagnosis of BRWS and a review of the current literature on HL in these syndromes.
Analysis of the Evolution of the Policy of Linking the Increase and Decrease in Urban and Rural Construction Land in China Based on the Content Analysis Method
Authors: Ding Weilai , Rao Jiao , Zhu Hongbo
Published: March 2024

The policy of linking the increase and decrease in urban and rural construction land is a land policy that gradually forms and develops to solve the contradiction between “food and construction” under the background of urbanization in China. It is of great significance to the sustainable development of China’s social economy. In order to grasp the evolution of the policy of linking the increase and decrease in urban and rural construction land in China as a whole, this paper used the content analysis method to analyze the changes in the content of China’s urban−rural construction land increase/decrease linkage policy from different perspectives, such as the levels of policy promulgation and the types of policy promulgation. Firstly, 105 directly related policy texts were selected from a large amount of policy information and read in detail with this as a sample, and 11 keywords were extracted, which were “balance of occupation and compensation”, “clear property rights”, “reasonable planning”, “project area”, “turnover indicators”, “linkage procedure”, “voluntary principle”, “resettlement compensation”, “cultivated land protection”, “supervision and management”, and “capital finance and taxation”. Secondly, the policy text was coded to provide quantitative data on policy development. Finally, the trajectory of policy development was analyzed on the basis of the quantitative data on policy development. The results show that the existing policies were mostly issued in the form of notifications, management measures, implementation plans, working rules, and so on, involving the nature, principles, conditions, methods, procedures, capital finance and taxation, and circulation indicators of the linkage between the increase and decrease, but the policy effectiveness is low, and there is a lack of formal laws and regulations. Improving the legal status of the policy, changing the relationship between the government and the market, strengthening the protection of cultivated land, and reconstructing the income distribution mechanism will help to further improve the policy of linking the increase and decrease in urban and rural construction land.
Tribological Properties of Al2O3/Graphite-Al2O3 Laminated Composites under Water Lubrication Conditions
Authors: Di Zhengxian , Wang Zhijia , Zhang Xiaoyu , Si Jiaxin , Song Junjie , Fan Hengzhong , Su Yunfeng , Hu Litian , Zhang Yongsheng
Published: March 2024

High-performance Al2O3/graphite-Al2O3 laminated composites exhibit an excellent self-lubricating ability for moving components, such as sliding shaft sleeves and dynamic seals. The tribological behaviors of Al2O3/graphite-Al2O3 laminated composites should be studied extensively under water working conditions. Here, we attempted to explore the practicability of the Al2O3/graphite-Al2O3 laminated composite as a sealing material from a tribological point of view under water lubrication conditions. The tribological properties and mechanism of friction and wear of laminated composite ceramics were investigated under dry sliding friction, water environment, and suspended particle working conditions. It was found that the Al2O3/graphite-Al2O3 laminated composite has a better friction performance under water lubrication compared to dry sliding because of the separation effects formed by a water molecule film and a transfer film. Meanwhile, the wear rate under dry contact was found to be approximately six times that under water lubrication conditions. Under the water lubrication conditions, the formation of graphite films and water-adsorbed layers improved the anti-wear properties of the laminated materials, and the friction coefficient and the wear rate were as low as 0.16 and 1.76 × 10−6 mm3/Nm, respectively. Under the suspended particle working condition, the solid particles destroyed the graphite lubricating film and abrasive wear dominated the wear mode. The Al2O3/graphite-Al2O3 laminated composite demonstrates a potential for application in dynamic sealing and sliding components.
Area-Controlled Soft Contact Probe: Non-Destructive Robust Electrical Contact with 2D and Fragile Materials
Authors: Yoshitake Michiko , Omata Kaori , Kanematsu Hideyuki
Published: March 2024

We developed a soft contact probe capable of making electrical contact with a specimen without causing damage. This probe is now commercially available. However, the contact area with the probe changes according to the pressure applied during electric contact, potentially affecting electric measurements when current density or electric field strength is critical. To address this, we developed methods to control the area of electric contact. This article reports on these methods, as well as variations in probe size, pressure for electric contact, probe materials, and attachment to commercial probers.
Photonic Crystal Structures for Photovoltaic Applications
Authors: Starczewska Anna , Kępińska Mirosława
Published: March 2024

Photonic crystals are artificial structures with a spatial periodicity of dielectric permittivity on the wavelength scale. This feature results in a spectral region over which no light can propagate within such a material, known as the photonic band gap (PBG). It leads to a unique interaction between light and matter. A photonic crystal can redirect, concentrate, or even trap incident light. Different materials (dielectrics, semiconductors, metals, polymers, etc.) and 1D, 2D, and 3D architectures (layers, inverse opal, woodpile, etc.) of photonic crystals enable great flexibility in designing the optical response of the material. This opens an extensive range of applications, including photovoltaics. Photonic crystals can be used as anti-reflective and light-trapping surfaces, back reflectors, spectrum splitters, absorption enhancers, radiation coolers, or electron transport layers. This paper presents an overview of the developments and trends in designing photonic structures for different photovoltaic applications.
The Influence of Flame Exposure and Solid Particle Erosion on Tensile Strength of CFRP Substrate with Manufactured Protective Coating
Authors: Golewski Przemysław , Budka Michał
Published: March 2024

This paper presents the results of laboratory tests for new materials made of a carbon fibre-reinforced polymer (CFRP) composite with a single-sided protective coating. The protective coatings were made of five different powders—Al2O3, aluminium, quartz sand, crystalline silica and copper—laminated in a single process during curing of the prepreg substrate with an epoxy matrix. The specimens were subjected to flame exposure and solid particle erosion tests, followed by uniaxial tensile tests. A digital image correlation (DIC) system was used to observe the damage location and deformation of the specimens. All coatings subjected to solid particle erosion allowed an increase in tensile failure force ranging from 5% to 31% compared to reference specimens made of purely CFRP. When exposed to flame, only three of the five materials tested, Al2O3, aluminium, quartz sand, could be used to protect the surface, which allowed an increase in tensile failure force of 5.6%.
The Impact of Marangoni and Buoyancy Convections on Flow and Segregation Patterns during the Solidification of Fe-0.82wt%C Steel
Authors: Sari Ibrahim , Wu Menghuai , Ahmadein Mahmoud , Ataya Sabbah , Alrasheedi Nashmi , Kharicha Abdellah
Published: March 2024

Due to the high computational costs of the Eulerian multiphase model, which solves the conservation equations for each considered phase, a two-phase mixture model is proposed to reduce these costs in the current study. Only one single equation for each the momentum and enthalpy equations has to be solved for the mixture phase. The Navier–Stokes and energy equations were solved using the 3D finite volume method. The model was used to simulate the liquid–solid phase transformation of a Fe-0.82wt%C steel alloy under the effect of both thermocapillary and buoyancy convections. The alloy was cooled in a rectangular ingot (100 × 100 × 10 mm3) from the bottom cold surface to the top hot free surface by applying a heat transfer coefficient of h = 600 W/m2/K, which allows for heat exchange with the outer medium. The purpose of this work is to study the effect of the surface tension on the flow and segregation patterns. The results before solidification show that Marangoni flow was formed at the free surface of the molten alloy, extending into the liquid depth and creating polygonized hexagonal patterns. The size and the number of these hexagons were found to be dependent on the Marangoni number, where the number of convective cells increases with the increase in the Marangoni number. During solidification, the solid front grew in a concave morphology, as the centers of the cells were hotter; a macro-segregation pattern with hexagonal cells was formed, which was analogous to the hexagonal flow cells generated by the Marangoni effect. After full solidification, the segregation was found to be in perfect hexagonal shapes with a strong compositional variation at the free surface. This study illuminates the crucial role of surface-tension-driven Marangoni flow in producing hexagonal patterns before and during the solidification process and provides valuable insights into the complex interplay between the Marangoni flow, buoyancy convection, and solidification phenomena.
C60- and CdS-Co-Modified Nano-Titanium Dioxide for Highly Efficient Photocatalysis and Hydrogen Production
Authors: Zhang Meifang , Liang Xiangfei , Gao Yang , Liu Yi
Published: March 2024

The inherent properties of TiO2, including a wide band gap and restricted spectral response range, hinder its commercial application and its ability to harness only 2–3% of solar energy. To address these challenges and unlock TiO2’s full potential in photocatalysis, C60- and CdS-co-modified nano-titanium dioxide has been adopted in this work to reduce the band gap, extend the absorption wavelength, and control photogenerated carrier recombination, thereby enhancing TiO2’s light-energy-harnessing capabilities and hydrogen evolution capacity. Using the sol-gel method, we successfully synthesized CdS-C60/TiO2 composite nanomaterials, harnessing the unique strengths of CdS and C60. The results showed a remarkable average yield of 34.025 μmol/h for TiO2 co-modified with CdS and C60, representing a substantial 17-fold increase compared to pure CdS. Simultaneously, the average hydrogen generation of C60-modified CdS surged to 5.648 μmol/h, a notable two-fold improvement over pure CdS. This work opens up a new avenue for the substantial improvement of both the photocatalytic degradation efficiency and hydrogen evolution capacity, offering promise of a brighter future in photocatalysis research.
Boundedness of Vector Linéard Equation with Multiple Variable Delays
Authors: Gözen Melek
Published: March 2024

In this article, we consider a system of ordinary differential equations (ODEs) of second order with two variable time delays. We obtain new conditions for uniform ultimate bounded (UUB) solutions of the considered system. The technique of the proof is based on the Lyapunov–Krasovskii functional (LKF) method using a new LKF. The main result of this article extends and improves a recent result for ODEs of second order with a constant delay to a more general system of ODEs of second order with two variable time delays. In this particular case, we also give a numerical example to verify the application of the main result of this article.
First Report of Pinnatoxin-G (PnTX-G) in a Marine–Coastal Area of the Adriatic Sea Associated with the Presence of the Dinoflagellate Vulcanodinium rugosum
Authors: Cangini Monica , Dall’Ara Sonia , Rubini Silva , Bertasi Barbara , Rizzi Paolo , Dell’Orfano Giovanni , Milandri Stefania , Manfredini Stefano , Baldini Erika , Vertuani Silvia
Published: March 2024

This study reports the first detection of the marine neurotoxin pinnatoxin-G (PnTX-G) in clams collected in the northwestern Adriatic Sea (Italy). It also represents the first report of the potential toxin-producing dinoflagellate, Vulcanodinium rugosum, in Italian seas. This result, from the coasts of the Emilia-Romagna Region, indicates a successful colonization process, reflecting conditions in France where V. rugosum was initially documented. In this case, the concentration of PnTXs was very low, making further sampling necessary to fully understand the extent of the phenomenon. Discussions on the need to obtain more data to support a proper risk assessment and the need to implement a monitoring program that includes emerging marine biotoxins are also included.
Fabrication of Eco-Friendly Hydrolyzed Ethylene–Maleic Anhydride Copolymer–Avermectin Nanoemulsion with High Stability, Adhesion Property, pH, and Temperature-Responsive Releasing Behaviors
Authors: Cheng Yuxin , Pan Zeyu , Tang Liming , Huang Yanbin , Yang Wantai
Published: March 2024

In this study, novel amphiphilic polymer emulsifiers for avermectin (Avm) were synthesized facilely via the hydrolysis of ethylene-maleic anhydride copolymer (EMA) with different agents, and their structures were confirmed by various techniques. Then, water-based Avm-nanoemulsions were fabricated with the emulsifiers via phase inversion emulsification process, and superior emulsifier was selected via the emulsification effects. Using the superior emulsifier, an optimal Avm-nanoemulsion (defined as Avm@HEMA) with satisfying particle size of 156.8 ± 4.9 nm, encapsulation efficiency (EE) of 69.72 ± 4.01% and drug loading capacity (DLC) of 54.93 ± 1.12% was constructed based on response surface methodology (RSM). Owing to the emulsifier, the Avm@HEMA showed a series of advantages, including high stability, ultraviolet resistance, low surface tension, good spreading and high affinity to different leaves. Additionally, compared to pure Avm and Avm-emulsifiable concentrate (Avm-EC), Avm@HEMA displayed a controlled releasing feature. The encapsulated Avm was released quite slowly at normal conditions (pH 7.0, 25 °C or 15 °C) but could be released at an accelerated rate in weak acid (pH 5.5) or weak alkali (pH 8.5) media or at high temperature (40 °C). The drug releasing profiles of Avm@HEMA fit the Korsmeyer–Peppas model quite well at pH 7.0 and 25 °C (controlled by Fickian diffusion) and at pH 7.0 and 10 °C (controlled by non-Fickian diffusion), while it fits the logistic model under other conditions (pH 5.5 and 25 °C, pH 8.5 and 25 °C, pH 7.0 and 40 °C).
Differences in Plasma 25-Hydroxyvitamin D Levels at Diagnosis of Celiac Disease and Type 1 Diabetes
Authors: Marino Monica , Galeazzi Tiziana , Gesuita Rosaria , Ricci Salima , Catassi Carlo , Cherubini Valentino , Lionetti Elena
Published: March 2024

Aim: The aim of this work is to assess the vitamin D levels, evaluated as plasma 25-hydroxyvitamin D of children with a new diagnosis of celiac disease (CD), of children with a new onset of type 1 diabetes (T1D) and in children with CD at diagnosis of T1D (T1D&CD). Methods: In this single-center observational study, we collected data for four groups of children and adolescents: T1D, CD, T1D&CD, and a control group (CG). The CG included schoolchildren who had negative results during a mass screening campaign for CD and were not diagnosed for T1D, according to RIDI Marche registry data, were considered for the purposes of this study. Plasma 25-hydroxyvitamin D, 25(OH)D2, and 25(OH)D3 were considered as the parameters for evaluating vitamin D nutritional status, and the date of measurement was recorded to analyze vitamin D level seasonality. Vitamin D nutritional status was categorized as follows: severe deficiency (<10 ng/mL), deficiency (<20 ng/mL), insufficiency (20–29 ng/mL), or sufficiency/adequacy (≥30 ng/mL). The Kruskal–Wallis test was used to compare the groups. The association of 25(OH)D levels with health conditions and seasonal differences of 25(OH)D levels was analyzed using a multiple linear regression model. Results: The number of children enrolled for the present study was 393: 131 in the CG, 131 CD, 109 T1D, and 22 T1D&CD. Significantly lower levels of vitamin D were displayed for children with CD, T1D, or both the diseases. Interestingly, severe vitamin D deficiency was detected in no children with CD, 1.5% of children in the CG, in 24.4% with T1D, and 31.8% with T1D&CD (p < 0.001). As expected, the CG children vitamin D levels were significantly influenced by seasonality. Contrarily, no seasonal differences were reported in children with CD, T1D, and T1D&CD. Multiple regression analysis showed that children with T1D and T1D&CD had lower 25(OH)D levels of 9.9 ng/mL (95% CI: 5.4; 14.5) and 14.4 ng/mL (95% CI: 6.2–22.7) compared to CG children (p < 0.001). Conclusions: Our results showed low levels of vitamin D diagnosis of T1D, CD, and T1D&CD; however, severe deficiency was only reported in children with T1D and T1D&CD. More studies are needed to better understand the role of this deficiency in children newly diagnosed with CD and T1D.
Effects of Enteric-Coated Formulation of Sodium Bicarbonate on Bicarbonate Absorption and Gastrointestinal Discomfort
Authors: Jiang Fang-Lin , Jeong Dong-Ho , Eom Seon-Ho , Lee Hae-Moon , Cha Bong-Jin , Park Ju-Seong , Kwon RyoonKyoung , Nam Jeong-Yeon , Yu Hyun-Seon , Heo Su-Hak , Kim Chul-Hyun , Song Keon-Hyoung
Published: March 2024

Sodium bicarbonate is used as an ergogenic supplement to enhance people’s performances in various exercises. This study aimed to evaluate the effects of intestinal delivery of sodium bicarbonate on bicarbonate absorption and associated side effects in an experimental human trial. After preparing and assessing enteric-coated and uncoated sodium bicarbonate tablet formulations, pharmacokinetic analysis and gastrointestinal symptom tests were performed after oral administration in the human body. The dose required to increase blood bicarbonate concentration over 5 mmol∙L−1 for the purpose of improving performance during high-intensity exercise was also determined. Enteric-coated tablet formulation protects sodium bicarbonate under acidic conditions and releases bicarbonate in the intestine. Enteric-coated tablet formulation also reduced the oral dose required to achieve a blood bicarbonate concentration over 5 mmol∙L−1 from 300 mg∙kg−1 of uncoated tablet formulation to 225 mg∙kg−1. Gastrointestinal discomfort was significantly decreased for the group given 225 mg∙kg−1 enteric-coated tablets compared to that given 300 mg∙kg−1 uncoated tablets. These results suggest that enteric-coated tablet formulation could reduce the oral dose required in order to achieve a blood bicarbonate concentration over 5 mmol∙L−1 by 25%, from 300 mg∙kg−1 to 225 mg∙kg−1, along with its ability to reduce gastrointestinal discomfort associated with the dosage.
Taurine Prevents Angiotensin II-Induced Human Endocardial Endothelium Morphological Remodeling and the Increase in Cytosolic and Nuclear Calcium and ROS
Authors: Jacques Danielle , Bkaily Ghassan
Published: March 2024

Endocardial endothelium (EE) is a layer of cells covering the cardiac cavities and modulates cardiomyocyte function. This cell type releases several cardioactive factors, including Angiotensin II (Ang II). This octopeptide is known to induce cardiac hypertrophy. However, whether this circulating factor also induces EE hypertrophy is not known. Taurine is known to prevent cardiac hypertrophy. Whether this endogenous antioxidant prevents the effect of Ang II on human EE (hEE) will be verified. Using quantitative fluorescent probe imaging for calcium and reactive oxygen species (ROS), our results show that Ang II induces (10−7 M, 48 h treatment) an increase in hEE cell (hEEC) volume and its nucleus. Pretreatment with 20 mM of taurine prevents morphological remodeling and increases intracellular calcium and ROS. These results suggest that the reported Ang II induces cardiac hypertrophy is associated with hEEC hypertrophy. This later effect is prevented by taurine by reducing intracellular calcium and ROS overloads. Thus, taurine could be an excellent tool for preventing Ang II-induced remodeling of hEECs.
Supplementing Ryegrass Ameliorates Commercial Diet-Induced Gut Microbial Dysbiosis-Associated Spleen Dysfunctions by Gut–Microbiota–Spleen Axis
Authors: Ali Qasim , Ma Sen , Liu Boshuai , Niu Jiakuan , Liu Mengqi , Mustafa Ahsan , Li Defeng , Wang Zhichang , Sun Hao , Cui Yalei , Shi Yinghua
Published: March 2024

The type and composition of food strongly affect the variation and enrichment of the gut microbiota. The gut–microbiota–spleen axis has been developed, incorporating the spleen’s function and maturation. However, how short-chain fatty-acid-producing gut microbiota can be considered to recover spleen function, particularly in spleens damaged by changed gut microbiota, is unknown in geese. Therefore, the gut microbial composition of the caecal chyme of geese was assessed by 16S rRNA microbial genes, and a Tax4Fun analysis identified the enrichment of KEGG orthologues involved in lipopolysaccharide production. The concentrations of LPS, reactive oxygen species, antioxidant/oxidant enzymes, and immunoglobulins were measured from serum samples and spleen tissues using ELISA kits. Quantitative reverse transcription PCR was employed to detect the Kelch-like-ECH-associated protein 1–Nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2), B cell and T cell targeting markers, and anti-inflammatory/inflammatory cytokines from the spleen tissues of geese. The SCFAs were determined from the caecal chyme of geese by using gas chromatography. In this study, ryegrass-enriched gut microbiota such as Eggerthellaceae, Oscillospiraceae, Rikenellaceae, and Lachnospiraceae attenuated commercial diet-induced gut microbial alterations and spleen dysfunctions in geese. Ryegrass significantly improved the SCFAs (acetic, butyric, propionic, isovaleric, and valeric acids), AMPK pathway-activated Nrf2 redox signaling cascades, B cells (B220, CD19, and IgD), and T cells (CD3, CD4, CD8, and IL-2, with an exception of IL-17 and TGF-β) to activate anti-inflammatory cytokines (IL-4 and IL-10) and immunoglobulins (IgA, IgG, and IgM) in geese. In conclusion, ryegrass-improved reprogramming of the gut microbiota restored the spleen functions by attenuating LPS-induced oxidative stress and systemic inflammation through the gut–microbiota–spleen axis in geese.
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain
Authors: Abdullahi Idris Nasir , Lozano Carmen , González-Azcona Carmen , Zarazaga Myriam , Torres Carmen
Published: March 2024

Coagulase-negative staphylococci (CoNS) species in healthy dogs and their owners could be transferred between these hosts and carry diverse antimicrobial resistance (AMR) genes of public health concern. This study determined the frequency, diversity, and AMR genes of nasal CoNS from healthy dogs and in-contact people as well as the rate of intra-household (between healthy dogs and dog-owners) transmission of CoNS. Nasal samples were collected and processed from 34 dogs and 41 humans from 27 households, and CoNS identification was done by MALDI-TOF-MS. The AMR determinants and genetic lineages were determined by PCR/sequencing. A total of 216 CoNS isolates were initially obtained and identified, and the AMR phenotypes were determined. From these, 130 non-repetitive CoNS were selected (one isolate of each species per sample or more than one if they presented different AMR phenotypes) and further characterized. The predominant species from dog carriers were S. epidermidis (26.5%), S. hominis (8.8%), and S. cohnii (8.8%), whereas in the human carriers, the predominant ones were S. epidermidis (80.4%), S. lugdunensis (9.8%), and S. hominis (9.8%). Intra-host species diversity (>one CoNS species) was detected in 37.5% of dogs and 21.6% of dog-owners. Conversely, 50% of dogs and 70.3% of dog-owners had intra-species AMR diversity (2–4 AMR-CoNS profiles). About 20% were susceptible to all antimicrobial agents tested, 31.5% displayed a multidrug resistance phenotype, and 17.4% were mecA-positive, located in SCCmec type V (24.2%), III (18.1%), IVc (12.1%), and II (6.1%). The other mec-A positive CoNS isolates (39.5%) had non-typeable SCCmec. The highest AMR rates were found against erythromycin (32.3%/mph(C), msr(A)) and mupirocin (20.8%/mupA), but the resistance rates for other antimicrobial agents were <10% each. Remarkably, one linezolid-resistant S. epidermidis-ST35 isolate was identified and mediated by four amino acid substitutions in L3 and one in L4 ribosomal proteins. Dogs and dog-owners as carriers of S. epidermidis with similar AMR patterns and genetic lineages (ST59, ST61, ST166 and ST278) were detected in four households (14.8%). Diverse CoNS carriage and moderate level of AMR were obtained from this study. The detection of CoNS carrying diverse SCCmec elements and intra-species AMR diversity highlights the roles of dog ownership in the potential transmission of antimicrobial-resistant CoNS in either direction.
Identification of mIDH1 R132C/S280F Inhibitors from Natural Products by Integrated Molecular Docking, Pharmacophore Modeling and Molecular Dynamics Simulations
Authors: Zhang Weitong , Bai Hailong , Wang Yifan , Wang Xiaorui , Jin Ruyi , Guo Hui , Lai Huanling , Tang Yuping , Wang Yuwei
Published: March 2024

Mutant isocitrate dehydrogenase 1 (mIDH1) is a common driving factor in acute myeloid leukemia (AML), with the R132 mutation accounting for a high proportion. The U.S. Food and Drug Administration (FDA) approved Ivosidenib, a molecular entity that targets IDH1 with R132 mutations, as a promising therapeutic option for AML with mIDH1 in 2018. It was of concern that the occurrence of disease resistance or recurrence, attributed to the IDH1 R132C/S280F second site mutation, was observed in certain patients treated with Ivosidenib within the same year. Furthermore, it should be noted that most mIDH1 inhibitors demonstrated limited efficacy against mutations at this specific site. Therefore, there is an urgent need to investigate novel inhibitors targeting mIDH1 for combating resistance caused by IDH1 R132C/S280F mutations in AML. This study aimed to identify novel mIDH1 R132C/S280F inhibitors through an integrated strategy of combining virtual screening and dynamics simulations. First, 2000 hits were obtained through structure-based virtual screening of the COCONUT database, and hits with better scores than −10.67 kcal/mol were obtained through molecular docking. A total of 12 potential small molecule inhibitors were identified through pharmacophore modeling screening and Prime MM-GBSA. Dynamics simulations were used to study the binding modes between the positive drug and the first three hits and IDH1 carrying the R132C/S280F mutation. RMSD showed that the four dynamics simulation systems remained stable, and RMSF and Rg showed that the screened molecules have similar local flexibility and tightness to the positive drug. Finally, the lowest energy conformation, hydrogen bond analysis, and free energy decomposition results indicate that in the entire system the key residues LEU120, TRP124, TRP267, and VAL281 mainly contribute van der Waals forces to the interaction, while the key residues VAL276 and CYS379 mainly contribute electrostatic forces.
Catalyzed Hydrothermal Pretreatment of Oat Husks for Integrated Production of Furfural and Lignocellulosic Residue
Authors: Puke Maris , Godina Daniela , Brazdausks Prans
Published: March 2024

This study presents a novel approach for biorefining oat husks into furfural, leveraging a unique pilot-scale setup. Unlike conventional furfural manufacturing processes, which often result in substantial cellulose degradation and environmental concerns associated with sulfuric acid usage, our method utilizes phosphoric acid as a catalyst to achieve high furfural yield while minimizing cellulose destruction. Drawing on our research conducted in a distinctive pilot-scale environment, we successfully developed and implemented a tailored biorefining process for oat husks. Through meticulous experimentation, we attained a remarkable furfural yield of 11.84% from oven-dried mass, accompanied by a 2.64% yield of acetic acid. Importantly, our approach significantly mitigated cellulose degradation, preserving 88.31% of the cellulose content in oat husks. Existing catalytic (H2SO4) furfural manufacturing processes often lead to substantial cellulose degradation (40–50%) in lignocellulosic leftover during the pretreatment stage. As a result of the research, it was also possible to reduce the destruction of cellulose in the lignocellulose leftover to 11.69% of the output (initial) cellulose of oat husks. This research underscores the feasibility and sustainability of utilizing oat husks as a valuable feedstock for furfural production, highlighting the potential of phosphoric acid as a catalyst in biorefining processes. By showcasing our unique pilot-scale methodology, this study contributes to advancing the field of environmentally friendly biorefining technologies.
An Updated Overview of Magnetic Composites for Water Decontamination
Authors: Niculescu Adelina-Gabriela , Mihaiescu Bogdan , Mihaiescu Dan , Hadibarata Tony , Grumezescu Alexandru
Published: March 2024

Water contamination by harmful organic and inorganic compounds seriously burdens human health and aquatic life. A series of conventional water purification methods can be employed, yet they come with certain disadvantages, including resulting sludge or solid waste, incomplete treatment process, and high costs. To overcome these limitations, attention has been drawn to nanotechnology for fabricating better-performing adsorbents for contaminant removal. In particular, magnetic nanostructures hold promise for water decontamination applications, benefiting from easy removal from aqueous solutions. In this respect, numerous researchers worldwide have reported incorporating magnetic particles into many composite materials. Therefore, this review aims to present the newest advancements in the field of magnetic composites for water decontamination, describing the appealing properties of a series of base materials and including the results of the most recent studies. In more detail, carbon-, polymer-, hydrogel-, aerogel-, silica-, clay-, biochar-, metal–organic framework-, and covalent organic framework-based magnetic composites are overviewed, which have displayed promising adsorption capacity for industrial pollutants.
The Influence of a Microstructural Conformation of Oriented Floating Films of Semiconducting Polymers on Organic Device Performance
Authors: Sharma Shubham , Gaurav Kumar Vivek , Nagamatsu Shuichi , Pandey Shyam S.
Published: March 2024

Extended π-conjugation with backbone-planarity-driven π-π stacking dominates charge transport in semiconducting polymers (SCPs). The roles of SCP film morphology and macromolecular conformation concerning the substrate in influencing charge transport and its impact on device performance have been a subject of extensive debate. Face-on SCPs promote out-of-plane charge transport primarily through π-π stacking, with conjugated polymeric chains assisting transport in connecting crystalline domains, whereas edge-on SCPs promote in-plane charge transport primarily through conjugation and π-π stacking. In this work, we fabricated three different types of devices, namely, organic field effect transistors, organic Schottky diodes, and organic bistable memristors, as representatives of planar and vertical devices. We demonstrate that a planar device, i.e., an organic field effect transistor, performs well in an edge-on conformation exhibiting a field-effect mobility of 0.12 cm2V−1s−1 and on/off ratio >104, whereas vertical devices, i.e., organic Schottky diodes and organic memristors, perform well in a face-on conformation, exhibiting exceptionally high on/off ratios of ~107 and 106, respectively.
Protective Effects of Carbonated Chitosan Montmorillonite on Vomitoxin-Induced Intestinal Inflammation
Authors: Tang Ruifan , Ju Xianghong , Niu Xueting , Liu Xiaoxi , Li Youquan , Yu Zhichao , Ma Xingbin , Gao Yuan , Li Yin , Xie Huili , Zhou Qiu , Yong Yanhong
Published: March 2024

Exposure to vomitoxin (DON) can negatively impact the intestinal health of livestock and poultry, leading to compromised nutrient absorption and utilization, resulting in slowed growth and reduced production efficiency. In this study, we synthesized carbonated chitosan montmorillonite intercalation complexes (CCM) through solution precipitation. The successful formation of intercalation complexes was confirmed by examining functional groups and surface features using infrared spectroscopy and scanning electron microscopy. To assess the impact of CCM on DON-infected mice, we established an experimental mouse model of jejunal inflammation induced by DON infection. We analyzed the effects of CCM on blood biochemical and conventional indices, jejunal inflammatory factors, pathological changes, and the expression of proteins in the MAPK pathways in DON-infected mice. Our results indicate that CCM effectively mitigates the adverse effects of DON on growth performance, jejunal injury, and the inflammatory response in mice. CCM supplementation alleviated the negative effects of DON infection on growth performance and reduced intestinal inflammation in mice. Moreover, CCM supplementation successfully inhibited the activation of the mitogen-activated protein kinase (MAPK) signaling pathway induced by DON. These findings suggest that the mitigating effect of CCM on DON-induced inflammatory injury in the murine jejunum is closely linked to the regulation of the MAPK signaling pathway.
A Novel Method for the Quantitative Evaluation of Retrograde Condensate Pollution in Condensate Gas Reservoirs
Authors: Zhao Hongxu , Zhang Xinghua , Gao Xinchen , Chen Peng , Guo Kangliang
Published: March 2024

During the development of condensate gas reservoirs, the phenomenon of retrograde condensation seriously affects the production of gas wells. The skin factor caused by retrograde condensation pollution is the key to measuring the consequent decrease in production. In this study, a multiphase flow model and a calculation model of retrograde condensate damage are first constructed through a dynamic simulation of the phase behavior characteristics in condensate gas reservoirs using the skin coefficient, and these models are then creatively coupled to quantitatively evaluate retrograde condensation pollution. The coupled model is solved using a numerical method, which is followed by an analysis of the effects of the selected formation and engineering parameters on the condensate saturation distribution and pollution skin coefficient. The model is verified using actual test data. The results of the curves show that gas–liquid two-phase permeability has an obvious effect on well production. When the phase permeability curve changes from the first to the third type, the skin coefficient increases from 3.36 to 26.6, and the condensate precipitation range also increases significantly. The distribution of the pollution skin coefficient also changes significantly as a result of variations in the formation and dew point pressures, well production, and formation permeability. The average error between the calculated skin of the model and the actual test skin is 3.87%, which meets the requirements for engineering calculations. These results have certain significance for guiding well test designs and the evaluation of condensate gas well productivity.
ML-Based Detection of DDoS Attacks Using Evolutionary Algorithms Optimization
Authors: Talpur Fauzia , Korejo Imtiaz Ali , Chandio Aftab Ahmed , Ghulam Ali , Talpur Mir. Sajjad Hussain
Published: March 2024

The escalating reliance of modern society on information and communication technology has rendered it vulnerable to an array of cyber-attacks, with distributed denial-of-service (DDoS) attacks emerging as one of the most prevalent threats. This paper delves into the intricacies of DDoS attacks, which exploit compromised machines numbering in the thousands to disrupt data services and online commercial platforms, resulting in significant downtime and financial losses. Recognizing the gravity of this issue, various detection techniques have been explored, yet the quantity and prior detection of DDoS attacks has seen a decline in recent methods. This research introduces an innovative approach by integrating evolutionary optimization algorithms and machine learning techniques. Specifically, the study proposes XGB-GA Optimization, RF-GA Optimization, and SVM-GA Optimization methods, employing Evolutionary Algorithms (EAs) Optimization with Tree-based Pipelines Optimization Tool (TPOT)-Genetic Programming. Datasets pertaining to DDoS attacks were utilized to train machine learning models based on XGB, RF, and SVM algorithms, and 10-fold cross-validation was employed. The models were further optimized using EAs, achieving remarkable accuracy scores: 99.99% with the XGB-GA method, 99.50% with RF-GA, and 99.99% with SVM-GA. Furthermore, the study employed TPOT to identify the optimal algorithm for constructing a machine learning model, with the genetic algorithm pinpointing XGB-GA as the most effective choice. This research significantly advances the field of DDoS attack detection by presenting a robust and accurate methodology, thereby enhancing the cybersecurity landscape and fortifying digital infrastructures against these pervasive threats.
Adaptive Time–Frequency Segment Optimization for Motor Imagery Classification
Authors: Huang Junjie , Li Guorui , Zhang Qian , Yu Qingmin , Li Ting
Published: March 2024

Motor imagery (MI)-based brain–computer interface (BCI) has emerged as a crucial method for rehabilitating stroke patients. However, the variability in the time–frequency distribution of MI-electroencephalography (EEG) among individuals limits the generalizability of algorithms that rely on non-customized time–frequency segments. In this study, we propose a novel method for optimizing time–frequency segments of MI-EEG using the sparrow search algorithm (SSA). Additionally, we apply a correlation-based channel selection (CCS) method that considers the correlation coefficient of features between each pair of EEG channels. Subsequently, we utilize a regularized common spatial pattern method to extract effective features. Finally, a support vector machine is employed for signal classification. The results on three BCI datasets confirmed that our algorithm achieved better accuracy (99.11% vs. 94.00% for BCI Competition III Dataset IIIa, 87.70% vs. 81.10% for Chinese Academy of Medical Sciences dataset, and 87.94% vs. 81.97% for BCI Competition IV Dataset 1) compared to algorithms with non-customized time–frequency segments. Our proposed algorithm enables adaptive optimization of EEG time–frequency segments, which is crucial for the development of clinically effective motor rehabilitation.
Research on Sea State Signal Recognition Based on Beluga Whale Optimization–Slope Entropy and One Dimensional–Convolutional Neural Network
Authors: Li Yuxing , Gu Zhaoyu , Fan Xiumei
Published: March 2024

This study introduces a novel nonlinear dynamic analysis method, known as beluga whale optimization–slope entropy (BWO-SlEn), to address the challenge of recognizing sea state signals (SSSs) in complex marine environments. A method of underwater acoustic signal recognition based on BWO-SlEn and one-dimensional convolutional neural network (1D-CNN) is proposed. Firstly, particle swarm optimization–slope entropy (PSO-SlEn), BWO-SlEn, and Harris hawk optimization–slope entropy (HHO-SlEn) were used for feature extraction of noise signal and SSS. After 1D-CNN classification, BWO-SlEn were found to have the best recognition effect. Secondly, fuzzy entropy (FE), sample entropy (SE), permutation entropy (PE), and dispersion entropy (DE) were used to extract the signal features. After 1D-CNN classification, BWO-SlEn and 1D-CNN were found to have the highest recognition rate compared with them. Finally, compared with the other six recognition methods, the recognition rates of BWO-SlEn and 1D-CNN for the noise signal and SSS are at least 6% and 4.75% higher, respectively. Therefore, the BWO-SlEn and 1D-CNN recognition methods proposed in this paper are more effective in the application of SSS recognition.
Quantifying the Financial and Climate Impacts of Greenhouse Gas Abatement Pathways in Residential Space Heating
Authors: Dill Alexandra , Brown Tristan R. , Malmsheimer Robert W. , Ha HakSoo , Frank Jenny , Kileti Pradheep , Barkwill Brian
Published: March 2024

New York State (NYS) has set strict greenhouse gas (GHG) emission reduction targets across all sectors of its economy, including the heating sector. This study examines the financial value and environmental impacts of the residential space heating sector in NYS under different GHG abatement options by comparing the existing natural gas heating pathway with three potential GHG abatement pathways: renewable natural gas (RNG), hydrogen blended into RNG, and air-source heat pumps (ASHPs). These pathways are analyzed via a comparative net present value (NPV) framework from 2022 to 2042 with the emission reduction represented as a revenue stream that serves as a function of the social cost of GHGs. The investment timing of each of these pathways is also accounted for to reflect the pathways’ varying deployment timelines. The ASHP pathway with a 10% financial discount rate and a 2% social cost of the GHG discount rate achieves the lowest NPV. The RNG pathway achieves the highest NPV. A sensitivity analysis determines the impact of key factors on the NPV results. This study aims to inform policymakers, homeowners, and stakeholders of the potential benefits and costs of each of the four pathways to aid them in their decision-making process.
Maximum Entropy Analysis of Bird Diversity and Environmental Variables in Nanjing Megapolis, China
Authors: Lai Jingcheng , Wang Yong , Huang Tengjie , Lyu Yanyan , Zhao Yuhui , Liu Jishuang
Published: March 2024

Against the background of global climate change and urbanization, the biodiversity of birds is facing unprecedented threats. In this paper, taking the Nanjing megapolis as an example, based on the distribution sites of 79 bird species and 17 environmental variables, the MaxEnt model was used to simulate the distribution of bird diversity, and the most important environmental variables were analyzed. The results show that (1) the MaxEnt model is suitable for simulation of the potential distribution of bird diversity in the Nanjing megapolis; (2) the areas with the highest bird diversity in the Nanjing megapolis were mainly distributed in the mountains and hills where the forests are located; (3) the five most important environmental variables affecting bird distribution were ranked as maximum temperature of the warmest month (MTWM) > Digital Elevation Model (DEM) > precipitation of the wettest month (PWM) > distance to the nearest forest (DF) > Fractional Vegetation Cover index (FVC), with MTWM, PWM, and DF being negatively correlated with bird diversity, whereas FVC and DEM exhibited positive correlations with bird diversity; and (4) the contribution rates of the three types of environmental variables were ranked as follows: habitat environmental variables > meteorological environmental variables > disturbance environmental variables. Sufficient bird habitats should be maintained in cities, and disturbances from human activities should be reduced to achieve the harmonious coexistence of humans and animals in the context of climate change and urbanization, thereby promoting sustainable development.
Factors Affecting Propensity to Lift-Share for Children’s Activities
Authors: de Kremer Sarah-Anne , Ross Tracy , Enoch Marcus Paul , Monsuur Fredrik
Published: March 2024

Research Problem: Families with children travel by car more frequently than any other household type and hence significantly contribute to transport externalities. Lift-sharing is a potential time-effective and convenient means of mitigating these effects. Whilst some research has been conducted on lift-sharing for the school run, there is little research beyond this context, particularly around lift-sharing for children’s activities (e.g., sport). Study Aim: Consequently, the aim of this study was to assess the current prevalence of lift-sharing (for children’s activities and other types of trips) in families with young children, the factors influencing its uptake, the experiences and attitudes of regular lift-sharers, and whether previous literature findings on reciprocity applied in this context to gain a deeper understanding of how and why families participate in activity lift-sharing. Research Design: A mixed-methods approach was applied, comprising (1) a travel survey of 474 families to establish socio-demographic and activity factors that influence lift-share prevalence for activity trips; and (2) 15 semi-structured interviews with parents to further explore how and why families participate in activity lift-sharing. Results: Factors influencing lift-sharing decisions for activity travel were number of cars owned, number of seats in the car, settlement type, income, time of day and location of the activity, number of children attending, parking availability, whether the activity is a sporting activity or not, and number of close friends of the child at the same activity. Salient motivating factors triggering lift-sharing included intentions to reduce chauffeuring and parents wanting their children to socialise. Trust was an initial imperative component of lift-share formation, and attitudes towards reciprocity supported previous literature findings relating to the variability of acceptable reciprocation and the role of fairness.