bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of xylose epimerase on sugar assimilation and sensing in recombinant Saccharomyces cerevisiae carrying different xylose-utilization pathways
Authors: Persson Viktor C. , Perruca Foncillas Raquel , Anderes Tegan R. , Ginestet Clément , Gorwa-Grauslund Marie
Published: November 2023

Background

Over the last decades, many strategies to procure and improve xylose consumption in Saccharomyces cerevisiae have been reported. This includes the introduction of efficient xylose-assimilating enzymes, the improvement of xylose transport, or the alteration of the sugar signaling response. However, different strain backgrounds are often used, making it difficult to determine if the findings are transferrable both to other xylose-consuming strains and to other xylose-assimilation pathways. For example, the influence of anomerization rates between α- and β-xylopyranose in pathway optimization and sugar sensing is relatively unexplored.

Results

In this study, we tested the effect of expressing a xylose epimerase in S. cerevisiae strains carrying different xylose-consuming routes. First, XIs originating from three different species in isogenic S. cerevisiae strains were tested and the XI from Lachnoclostridium phytofermentans was found to give the best performance. The benefit of increasing the anomerization rate of xylose by adding a xylose epimerase to the XI strains was confirmed, as higher biomass formation and faster xylose consumption were obtained. However, the impact of xylose epimerase was XI-dependent, indicating that anomer preference may differ from enzyme to enzyme. The addition of the xylose epimerase in xylose reductase/xylitol dehydrogenase (XR/XDH)-carrying strains gave no improvement in xylose assimilation, suggesting that the XR from Spathaspora passalidarum had no anomer preference, in contrast to other reported XRs. The reduction in accumulated xylitol that was observed when the xylose epimerase was added may be associated with the upregulation of genes encoding endogenous aldose reductases which could be affected by the anomerization rate. Finally, xylose epimerase addition did not affect the sugar signaling, whereas the type of xylose pathway (XI vs. XR/XDH) did.

Conclusions

Although xylose anomer specificity is often overlooked, the addition of xylose epimerase should be considered as a key engineering step, especially when using the best-performing XI enzyme from L. phytofermentans. Additional research into the binding mechanism of xylose is needed to elucidate the enzyme-specific effect and decrease in xylitol accumulation. Finally, the differences in sugar signaling responses between XI and XR/XDH strains indicate that either the redox balance or the growth rate impacts the SNF1/Mig1p sensing pathway.
Mitochondrial disorders as a mechanism for the development of obese Sarcopenia
Authors: Liao Tingfeng , Xiong Lijiao , Wang Xiaohao , Yang Shu , Liang Zhen
Published: November 2023

Obese sarcopenia is a severe and prevalent disease in an aging society. Compared to sarcopenia alone, the development and advanced stage of obesity sarcopenia is faster and more severe. Diagnosis of the cause of adipocyte accumulation is also more complicated; however, no effective pharmacological treatment is available. Chronic inflammation is one of the causes of sarcopenia, and obese patients, who are more likely to develop chronic inflammation, may simultaneously suffer from obesity and sarcopenia. Mitochondrial metabolic disorders have been more easily observed in the tissue cells of patients with obesity and sarcopenia. Mitochondrial metabolic disorders include abnormal mtDNA release, mitochondrial autophagy, and dynamic mitochondrial disorders. Therefore, this review will reveal the mechanism of development of obesity myasthenia gravis from the perspective of mitochondria and discuss the currently existing small-molecule drugs.
High-dose atorvastatin reduces oxidative stress of ischemia/reperfusion injury after isogeneic kidney transplantation in rats: in vivo, preclinical, case–control, open-label study
Authors: Cusumano Giacomo , Cola Edoardo , Spagnoletti Gionata , Severino Anna , Giubilato Simona , Stigliano Egidio , Caristo Maria Emiliana , Vischini Gisella , Liuzzo Giovanna , Salerno Maria Paola , Crea Filippo , Romagnoli Jacopo
Published: November 2023

Background

Renal ischemia/reperfusion injury is an unavoidable event in transplantation in which free radical-mediated injury determines release of pro-inflammatory cytokines and activation of innate immunity. In addition to their cholesterol-lowering action, statins have shown dose-dependent pleiotropic effects on inflammatory pathways and oxidative stress. We investigated the effects of high-dose atorvastatin (atorvastatin 40 mg/kg) in preventing ischemia/reperfusion injury in an animal model of kidney transplant.

Methods

Forty female rats underwent left nephrectomy and orthotopic autotransplantation. Animals were divided in four groups: A = Transplant only; B = high-dose atorvastatin + Transplant; C = right nephrectomy + Transplant; D = high-dose atorvastatin + right nephrectomy + Transplant. Bilateral nephrectomy was performed 24 h post-transplant. Oxidative stress was assessed measuring malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and myeloperoxidase (MPO) activity on renal tissue; ischemia/reperfusion injury was also evaluated by histology. Donor pre-treatment with high-dose atorvastatin improved oxidative stress.

Results

MDA levels were lower in group B versus A (p = 0.002) and D (p = 0.004). High-dose atorvastatin pre-treated rats displayed higher GPx activity in group B versus A (p = 0.009) and D (p = 0.005). SOD scavenger activity was also higher in group B versus A (p < 0.001) D (p < 0.001) and C (p = 0.003). MPO activity was lower in group B versus A (p = 0.02), C (p = 0.007) and D (p = 0.03). Histology revealed significantly lower rate of intratubular casts and luminal congestion in Group D versus C (p = 0.02 and p = 0.008, respectively).

Conclusions

High-dose atorvastatin pre-treatment reduces oxidative stress and inflammation in a model of kidney transplant in the rat.
Enhancing study quality assessment: an in-depth review of risk of bias tools for meta-analysis—a comprehensive guide for anesthesiologists
Authors: De Cassai Alessandro , Boscolo Annalisa , Zarantonello Francesco , Pettenuzzo Tommaso , Sella Nicolò , Geraldini Federico , Munari Marina , Navalesi Paolo
Published: November 2023

Background

Yearly, a multitude of randomized controlled trials are published, overwhelming clinicians with conflicting information; this data saturation leads to confusion and hinders clinicians’ everyday decision-making. Hence, it is crucial to assess the quality and reliability of the evidence in order to consolidate it. Through this synthesis, clinicians can guarantee that their decisions are informed by solid evidence. Meta-analysis, a statistical technique, can effectively combine data from multiple studies to furnish accurate and dependable evidence for clinical practice and policy decisions. Nonetheless, the reliability of the obtained results depends on the use of high-quality evidence.

Main body

Risk of bias is an assessment mandatory while performing a meta-analysis and is used to have an overview of the quality of the studies from which data are extracted. Several tools have been developed and are used to perform the risk of bias assessment. In this statistical round, we will provide an overview of the most used tools for both the randomized (Cochrane Risk of Bias 2 and Jadad) and the nonrandomized (Risk Of Bias In Non-randomized Studies and Newcastle–Ottawa Scale) clinical trials.

Conclusion

We provided an overview of the most used risk of bias tools used in meta-analysis.
Probabilistic physics-informed neural network for seismic petrophysical inversion
Authors: Li Peng , Liu Mingliang , Alfarraj Motaz , Tahmasebi Pejman , Grana Dario
Published: November 2023

The main challenge in the inversion of seismic data to predict the petrophysical properties of hydrocarbon-saturated rocks is that the physical relations that link the data to the model properties often are nonlinear and the solution of the inverse problem is generally not unique. As a possible alternative to traditional stochastic optimization methods, we develop a method to adopt machine-learning algorithms by estimating relations between data and unknown variables from a training data set with limited computational cost. We develop a probabilistic approach for seismic petrophysical inversion based on physics-informed neural network (PINN) with a reparameterization network. The novelty of our approach includes the definition of a PINN algorithm in a probabilistic setting, the use of an additional neural network (NN) for rock-physics model hyperparameter estimation, and the implementation of approximate Bayesian computation to quantify the model uncertainty. The reparameterization network allows us to include unknown model parameters, such as rock-physics model hyperparameters. Our method predicts the most likely model of petrophysical variables based on the input seismic data set and the training data set and provides a quantification of the uncertainty of the model. The method is scalable and can be adapted to various geophysical inverse problems. We test the inversion on a North Sea data set with poststack and prestack data to obtain the prediction of petrophysical properties. Compared with regular NNs, the predictions of our method indicate higher accuracy in the predicted results and allow us to quantify the posterior uncertainty.
The Neurosurgical Workforce of the Philippines
Authors: Baticulon Ronnie E. , Lucena Lynne Lourdes N. , Gimenez Michael Louis A. , Sabalza Michael N. , Soriano James A.
Published: November 2023

BACKGROUND AND OBJECTIVES:

No study has comprehensively examined the delivery of neurosurgical care in the Philippines, a lower-middle–income country in Southeast Asia with a total population of 109 million. We aimed to quantify the workforce, map the distribution, and characterize the clinical practice of neurosurgeons across the 17 regions and 81 provinces of the Philippines.

METHODS:

An online survey was sent to all fellows of the Academy of Filipino Neurosurgeons and all graduates of neurosurgical training programs in the country. Neurosurgeons who have been in active clinical practice for at least 1 year were eligible to participate. A database of Filipino neurosurgeons was generated through personal communications, correspondence with neurosurgery departments, and accessing publicly available information. The top neurosurgical procedures were identified to estimate the overall volume of neurosurgical disease.

RESULTS:

There are 174 neurosurgeons practicing in the Philippines or approximately one neurosurgeon for every 600 000 people. In 9 provinces, neurosurgeons were only available part-time, and 35 provinces had no neurosurgeons at all, equivalent to an underserved population of 24 million people. Among 99 survey respondents, the median numbers of neurosurgical consults and operations every month were 30 (IQR:35) and 8 (IQR:8), respectively. The top neurosurgical procedures were burr holes/craniotomy for traumatic brain injury, craniotomy for stroke, and biopsy/resection of brain tumors. There are an estimated 93 498 cases requiring essential neurosurgery every year.

CONCLUSION:

Although positive trends have been observed in the number, distribution, and composition of neurosurgeons in the Philippines, there remains a large workforce deficit that needs to be addressed to provide timely, quality, and affordable neurosurgical care to the entire population.
Nintedanib Treatment in a Child with Pulmonary Fibrosis
Authors: AKGÜL ERDAL Meltem , ALBOĞA Didem , SUNMAN Birce , ÖZCAN Hatice Nursun , EMİRALİOĞLU Nagehan , YALÇIN Ebru , DOĞRU Deniz , ÖZÇELİK Uğur , KİPER Nural
Published: November 2023

Pulmonary fibrosis (PF) in children is a very rare, progressive, and life-threatening condition. There are advances in the treatment of idiopathic PF in adults with the approval of antifibrotics like nintedanib. However, PF treatment in children is still an inconclusive area that needs to be studied further. Here, we present the nintedanib experience in a child with PF.
Histórias sobre o futuro possível: Projetos sociais, narrativas de vida e montagem audiovisual na série “Ideias para Mudar o Mundo”, do Canal OFF
Authors: Vallejos Pablo de Macedo Silveira
Published: November 2023

O artigo apresenta uma análise sobre o formato audiovisual proposto pela série “Ideias para Mudar o Mundo”, exibida no Canal OFF e disponibilizada na plataforma de streaming Globoplay. Por meio desse exercício, propõe reflexões acerca de narrativa de vida e montagem audiovisual, utilizando o episódio piloto dessa produção como objeto de estudo. Em contraponto, o trabalho traça uma leitura crítica e comparativa com outros dois títulos e percorre referências bibliográficas para observar de que maneira tais formatos ilustram uma estrutura padronizada, positiva, otimista sobre o futuro possível.
Exploring the delivery of end-of-life care by community nurses
Authors: Ferguson Elizabeth , Wiseman Leanne , Stratton Fiona , Evans Catherine , Linton Joanna , McLeod Laura , MacArthur Juliet
Published: November 2023

This study tested a method to capture feedback from bereaved family members and nurses about palliative and end of life care delivered in the community.

Aims:

To understand what aspects of care and support were important to bereaved relatives and to explore the experiences of nurses delivering end of life care.

Methods:

Interviews and focus groups were undertaken with 17 family members, 31 community nurses and 13 community hospital staff. A workshop was held with 6 family members, 13 community nurses and 3 hospital nurses to review findings and make recommendations for improvement.

Findings:

Four themes were identified: relationships and being treated as a whole person; being able to make choices; getting help when and where it is needed; specialist advice and care, especially at the very end of life.

Conclusion:

Seeking feedback from relatives was valued both by family members and the staff and has provided an effective model to lead to focussed improvements.
Cognitive frailty in older adults with diabetes: prevalence and risk factors
Authors: Mansoor Mohamed , Harrison Joanna , Hill James Edward
Published: November 2023

In older adults living with diabetes, there is a higher prevalence of frailty and a greater risk of cognitive impairment. Cognitive frailty is defined by the presence of both and is associated with an increased risk of mortality. A systematic review was undertaken to estimate the prevalence of cognitive frailty in community-dwelling older adults living with diabetes and associated risk factors. This commentary critically appraises the review and explores the implications of the findings for community practice.
The Voices of College Students in Learning Math Online, During the Covid Pandemic: The Hurdles, Upper Hands, and Takeaways
Authors: Aleguen Judith M. , Bascones Gabriel Y. , Bonotan Amelia M.
Published: November 2023

This descriptive phenomenological study looks into the lived experiences of teacher education college students on what it is like to learn math online during the COVID-19 pandemic. Due to the pandemic, online math learning may pose even more significant challenges. Hence, the researchers conducted the study to better understand and support the students in these challenging times. They interviewed 16 college student participants, who consented to participate in the study, to share their actual experiences - the challenges, struggles, and opportunities – in learning math online during the pandemic. The interview transcripts were analyzed following Colaizzi's method. Results revealed the following themes: (a) The hurdles: poor internet connection, unconducive learning space, difficulty in understanding the topics, financial problems, and health problems; (b) The upper hands: ease of access to varied resources, staying at home, and flexibility of the teaching and learning process; (c) The key takeaways: improved time management, self-discipline, resourcefulness, and growth mindset. The researchers recommend that the management of educational institutions consider the students' demographic data, financial level, available resources, and mental and emotional health while designing and implementing online programs. Further, future research may be conducted on the teachers' concerns that may influence students' online learning experiences with Math and other disciplines.
Unveiling the Linguistic Landscape: The Gendered Impacts on Language Learning Strategies for Introverted Learners
Authors: Le Thanh Thao , Nguyen Anh Thi , Thieu Thi Hai Yen , Phuong Hoang Yen , Pham Trut Thuy , Huynh Thi Anh Thu , Nguyen Huong Tra
Published: November 2023

This study explores the impact of gender on the preferred English language learning strategies of self-perceived introverted students in Vietnam, given the burgeoning role of English as an international lingua franca. A mixed-methods approach, involving survey questionnaires and follow-up interviews, was utilized to gather both quantitative and qualitative data from a cohort of 68 English major undergraduates, 29 of whom self-identified as introverted via the Myers-Briggs Type Indicator (MBTI). The investigation provides a comprehensive understanding of the preferred language learning strategies among introverted learners, and specifically examines how gender influences these strategic choices. The results reveal that gender does not present significant differences in the preferred English language learning strategies of self-perceived introverted individuals. Regardless of gender, introverted language learners demonstrate a tendency towards compensation learning strategies, with specific strategies such as deductive reasoning, organizing physical environs, and error rectification receiving almost identical responses from both male and female participants. These findings suggest that the role of personality traits, such as introversion, should be considered in tailoring pedagogical approaches to meet individual learning preferences and needs. Further research is needed to explore this area in greater depth and to examine its broader implications for English language teaching pedagogy.
Computational Thinking Through the Engineering Design Process in Chemistry Education
Authors: Samad Norhaslinda Abdul , Osman Kamisah , Nayan Nazrul Anuar
Published: November 2023

This study investigated the influence of CThink4CS2 Module on computational thinking (CT) skills of form four chemistry students. The CThink4CS2 Module integrated CT with the Engineering Design Process (EDP) in chemistry class. This study utilized quantitative research methods and quasi-experimental design. Quantitative data were collected using the Computational Thinking Skill Test (CTST) which consisted of algorithmic reasoning, abstraction, decomposition, and pattern recognition constructs. A total of 73 students were in the treatment group (n=39) and control group (n=34). Experimental data were described by means of descriptive analysis and inferential analysis employing two-way MANOVA analysis. The results of the analysis indicated significant differences in CT skills between groups; students in the treatment group demonstrated better results compared to those in the control group. The paper provides insight into the integration of CT and EDP as effective pedagogical strategies for inculcating CT skills.
The cost of beauty: Perspectives of salon workers in Kisumu City, Kenya
Authors: Onyango Patrick Ogola
Published: November 2023

Despite occupational exposure to hazardous chemicals in cosmetics and personal care products (PCPs), salon workers receive minimal formal protections. Consequently, most salon workers rely on personal safeguards. However, the nature of such individual-level safeguards remains unknown. Knowledge of risks associated with occupational use of cosmetics and PCPs and information needs of salon workers were investigated in Kisumu City, Kenya. Responses from 302 respondents showed that 84% were women and 30% had post-secondary education. Seventy percent reported knowing that ingestion, inhalation, dermal absorption, and injection are the pathways through which harmful products in cosmetics and PCPs may enter the body. Salon workers who had been employed for more than 5 years were at least twice more likely to report that it is not the case that cosmetics and PCPs only cause harm to children (5–10 years vs 1 year: OR = 2.440, 95% CI, 1.160–5.239; >10 years vs 1 year: OR = 8.857, 95% CI, 3.163–29.377); they were about three times more likely to either agree with the statement that cosmetics and PCPs only cause harm under prolonged exposure or to say that they did not know compared to their counterparts who had worked in the industry for 1 year (5–10 years vs 1 year: OR = 2.750, 95% CI, 1.144–7.179; >10 years vs 1 year: 3.179, 95% CI, 1.173–9.096). Over 50% of the respondents reported that they need information on how to protect themselves and others; on available protective measures; and on cosmetic products and PCPs that are safe. Sixty percent reported that they would prefer to get such information from the Ministry of Health at the county or national level and on product inserts. Overall, salon workers in Kisumu City are knowledgeable about the risks associated with their occupation but also appreciate gaps in their knowledge, which can be filled by government-mandated interventions.
Climate change adaptation research among vine growers: evidence from Mátra wine region
Authors:   , Király Gábor
Published: November 2023

Kivonat, rövid leírás This research contributes to the intensively growing climate change adaptation discourse with the examination of vine growers’ risk perception and risk management practices. In studies dealing with agricultural climate change adaptation issues, it is an often-cited statement that farming is a dynamic system that continuously responds to changing conditions. Such changing conditions are seen as risks induced by either climate change or other sources. This research systematically assessed these risks as a network of interrelated concepts, adopting a partially mixed sequential dominant research design, in which a quantitative research segment (a large sample of survey data) outlined the overall picture of Hungarian farmers' perceptions of climate change and adaptation behaviour and then an individual-based mental modelling approach was used to conduct a risk elicitation exercise embedded in qualitative interviews with vine growers. Despite the participants' diverse and complex mental models, the presence of a double pressure stood out from the results: one from the risks posed by the impacts of climate change, and another from the risks related to labour. The most obvious consequence of labour-related problems is that fewer and fewer people are willing and able to work in viticulture, which is a very labour-intensive activity. And risks that come with climate change, such as severe heat stress, lengthy droughts, and excessive UV radiation, will likely pose severe challenges for grape cultivation. Although the interaction of these two types of risks generates significant adaptation needs by exerting effects that should be addressed by a complex risk management approach, participants’ responses do not reflect this complexity. More precisely, participants’ responses indicate that in their multi-faceted risk landscape, labour-related risks have a greater influence on their risk management decisions than climate change related risks. This is well reflected in the evidence that their adaptation decisions have been focused on long-term solutions to labor-related problems, but only short-term decisions characterise their climate change adaptation behaviour. Despite all their perceived climate change related risks, participants still find themselves able to maintain their activities and keep cultivating grapes. This is because, on the one hand, climate risks are still seen as manageable with the available solutions, which consist primarily of tactical interventions. However, on the other hand, there appears to be considerable uncertainty regarding what should be done and how it should be done, so even these tactical interventions are surrounded by uncertainty. Multiple forms of uncertainty have been identified in this research, suggesting that if the climate situation worsens, the adaptive capacity of participants might be insufficient to cope with changes in climatic conditions.
The "Please Brush Toothbrush" Innovation
Authors: Samintarapanya Pattharadorn
Published: November 2023

Dental hygiene is a global concern, affecting both the population of Thailand and people around the world. One common issue is inadequate brushing practices, often due to insufficient brushing duration. To address this, we have undertaken the task of creating a toothbrush that utilizes the Arduino platform to notify users when they have brushed their teeth for the recommended two-minute duration. We've written and tested two sets of code to determine the best one for our innovative toothbrush. The "Please Brush Toothbrush" is designed to cater to individuals of all ages and successfully achieves the goal of ensuring a two-minute brushing time. However, we recognize that durability and strength are crucial aspects for future development. If given the opportunity to advance our production, we will continue to enhance the "Please Brush Toothbrush" to maximize its benefits for both the Thai population and people worldwide.
Gestão Democrática: Construção Coletiva e Participativa na Qualidade Educacional na Escola de Ensino Médio em Tempo Integral Jacob Nobre de Oliveira Benevides em Banabuiú – Ceará
Authors: Oliveira Maria Zilverlane de Lima , Lopes Raimundo Edilberto Moreira
Published: November 2023

Discutir sobre Gestão Democrática é abordar a temática do ensino de qualidade, pois ambos estão interligados. A educação é o pilar de toda sociedade e a busca por um ensino de qualidade como forma de democratizar o acesso e exercício da cidadania precisa ser a luta constante de toda sociedade justa. Em vista disso, apresenta-se a proposta de reconhecer a importância da Gestão Democrática no espaço da escola pública em todos os aspectos desde a inserção de todos os envolvidos nas tomadas de decisão ao pleno desenvolvimento do educando, para isso, apresenta-se um estudo de revisão bibliográfica. Dessa forma, o estudo se apresenta como uma análise reflexiva sobre a Gestão Democrática como um caminho para uma educação de qualidade. O presente trabalho se divide em dois momentos: Reflexões sobre o tema Gestão Escolar no contexto da escola pública embasada em autores e críticos renomados: Análise do resultado obtido através de uma pesquisa realizada em uma escola da rede pública estadual do Ceará.
Atualização Diagnóstica para a Covid-19
Authors: Costa Thalia Fernanda Araújo , Mendonça Vanessa Fernandes , Santos Thalita Grazielly , Pádua Karina Maciel
Published: November 2023

No final de 2019, o ciclo midiático foi tomado pelas notícias sobre o coronavírus, logo o mundo inteiro foi envolto pela pandemia da COVID-19. Segundo o New York Times, atualmente, o número é de 4.297.830 mortes no âmbito mundial, 202.872.928 total de casos. Ja no Brasil, até o momento, foram registrados 20.165.672 casos. Apesar da grande emergência desta pandemia causada pelo vírus SARS-CoV-2 em nosso país e no mundo, várias opções de metodologias diagnósticas têm sido criadas para nos auxiliar na detecção deste agente, contribuindo para evitar a sua disseminação, detectar quem já teve a doença e, em alguns casos, favorecer o tratamento precoce. Este trabalho tem como objetivo detalhar cada um destes métodos, descrevendo como cada um deles funcionam no diagnóstico da COVID-19. Este trabalho trata-se de um estudo bibliográfico, descritivo do tipo revisão integrativa da literatura, partindo do levantamento bibliográfico e análises de dados bibliográficos disponíveis de pesquisas anteriores.
O Desempenho do Coordenador Pedagógico frente à Execução do Projeto Político Pedagógico da Escola
Authors: De Souza Sampaio Ivonete Maria , Edilberto Moreira Lopes Raimundo
Published: November 2023

Um papel relativamente novo na conjuntura da educação brasileira, a função do Coordenador Pedagógico caracteriza-se pelo acompanhamento a prática dos professores, oferecendo-lhes condições para que trabalhem de modo a garantir a aprendizagem do aluno e se constituindo como mediador entre o trabalho docente e o Projeto Político Pedagógico da Escola. Dessa forma, a presente pesquisa tem como objetivo pesquisar como se concretiza na prática escolar o papel do Coordenador Pedagógico frente à efetivação do Projeto Político Pedagógico (PPP) da escola. O trabalho foca, no primeiro momento, o contexto histórico do surgimento da figura do coordenador pedagógico no âmbito escolar brasileiro, destacando desde a Primeira República quando surgiu o papel de inspetor até a expansão do ensino nos anos de 1950 que impulsionou necessidade da Supervisão Escolar separada da inspeção. Prosseguindo com a análise histórica o trabalho faz uma abordagem das principais modificações no papel desse profissional, as exigências de formação conforme a configuração da educação e de seus agentes em distintos momentos históricos da realidade educacional brasileira onde enfatiza no âmbito da noção de gestão democrática da escola o papel do coordenador pedagógico como articulador do Projeto Político Pedagógico e sua importância na orientação da prática docente, se constituindo como mediador entre a referida prática e o que vem proposto no Projeto Político Pedagógico da escola. Partindo do pressuposto que a dinâmica escolar e o cotidiano de trabalho do coordenador pedagógico muitas vezes são perpassados por eventos imediatos e imprevistos e por questões de ordem burocrática, o que acaba por desviar a função da equipe pedagógica para as tarefas imediatistas e burocráticas administrativas, buscou-se compreender como ocorre na realidade escolar essa função mediadora do coordenador pedagógico. para tanto, foram entrevistadas três coordenadoras pedagógicas em três diferentes escolas, de modo a analisar as implicações do trabalho do trabalho do coordenador pedagógico no desenvolvimento do projeto político pedagógico da escola. como resultado da pesquisa desenvolvida é possível perceber o distanciamento do coordenador pedagógico das funções de acompanhamento das práticas pedagógicas, inclusive aquelas que concorrem diretamente para efetivação do PPP da escola.
Síndrome de Burnout em Contextos de Estresse Laboral em Docentes, sob o Foco da Sociologia Jurídica
Authors: Campelo Maria Paula Silvestre , Ifadireó Miguel Melo
Published: November 2023

O contexto educacional no Brasil tem gerado preocupação por parte dos gestores e profissionais da área da Educação. O docente vem sofrendo com agentes estressores que afetam diretamente a qualidade do seu trabalho. Fatores como: salários baixos, excessivo número de alunos na classe, a relação com os discentes e a falta de valorização profissional, são alguns aspectos que estimulam o adoecimento mental e, em muitos casos, o Burnout. Esses episódios tornam-se mais frequentes e agravados nas instituições públicas de ensino, em relação aos estabelecimentos particulares. Destaca-se a importância da Sociologia, quanto ao adoecimento mental na atualidade, principalmente professores, a classe mais atingida nesse contexto, diante da interação constante desse profissional com a sociedade. Diante dessa conjuntura, esse estudo tem como finalidade, efetuar uma Revisão Bibliográfica da Literatura sobre a “Síndrome de Burnout em Contextos de Estresse Laboral em Docentes Sob o Foco da Sociologia jurídica”. Para isso foram pesquisados artigos nas plataformas científicas: Scielo, Google Scholar e Lilacs. Os princípios de inclusão foram artigos relacionados com o tema da pesquisa. O fatores de exclusão, foram artigos que não se referiam ao foco do estudo. As respostas da pesquisa apresentaram um cenário a presença do Burnout em, predominantemente,  prestadores de serviços, trabalhadores da área de tratamento e educadores. Os aspectos principais, como: a relação inter-profissional, excesso de trabalho, a baixa remuneração e a falta de reconhecimento profissional promovem o desenvolvimento do esgotamento emocional, que podem levar ao Burnout.
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Inteligência Emocional e suas Influências na Gestão de Conflitos
Authors: Ferreira Felipe Oliveira , Fonseca Maria Eduarda Seni , Nunes Ana Lúcia de Paula Ferreira
Published: November 2023

O estudo vigente teve como objetivo diagnosticar a importância da inteligência emocional no ambiente organizacional, e sua relevância na gestão de conflitos. É notória a escassez de gestores habilitados para administrar seus próprios sentimentos e gerirem os conflitos oriundos do ambiente empresarial A falta de habilidades emocionais adequadas pode resultar em comunicação inadequada, escalada de conflitos, baixa produtividade e clima organizacional negativo, além de perdas de talentos. Detectou-se que a inteligência emocional é uma ferramenta importante para solucionar e enfrentar tais conflitos, envolvendo o desenvolvimento da capacidade de reconhecer, compreender e gerenciar as emoções, tanto as próprias quanto as dos outros, ao fazer isso, as empresas podem melhorar a comunicação entre seus membros, promover a resolução construtiva de conflitos, criar um clima organizacional saudável e aumentar a retenção de talentos. Foram utilizados métodos como artigos, pesquisas bibliográficas, embasados nas obras do Stephen P. Robbins, Daniel Goleman, entre outros. Vale ressaltar que ao ignorar a inteligência emocional na solução de conflitos as empresas correm o risco de enfrentar problemas de comunicação, conflitos exacerbados, baixa produtividade e insatisfação dos funcionários, ao adotar a inteligência emocional como uma abordagem, as empresas podem promover uma cultura de colaboração, empatia e compreensão, resultando em uma equipe mais engajada, produtiva e feliz.
Projeto Político Pedagógico no Contexto da Gestão Escolar das Escolas Municipais de Banabuiú - Ceará
Authors: Silva Maria Rejane da , Villalba Osvaldo Arsênio
Published: November 2023

Esta pesquisa tem como objetivo principal identificar quais escolas estão empenhadas na execução do Projeto Político Pedagógico como instrumento de gestão participativa que provoque mudanças e inovações na organização escolar na sua globalidade. Assim, se fez necessário: descrever a participação dos segmentos na elaboração do projeto político pedagógico das escolas públicas da rede municipal de ensino de Banabuiú – Ceará; averiguar se o Projeto Político Pedagógico é realmente utilizado no planejamento das ações educativas pelas escolas; verificar se o Projeto Político Pedagógico está sendo revisto para atender as reais necessidades da escola e; descrever as principais dificuldades que surgiram no desenvolvimento do Projeto Político Pedagógico. A amostra da pesquisa foi composta por todos os gestores (diretores administrativos e coordenadores pedagógicos) do município de Banabuiú no ano de 2014, por três professores, um pai de alunos, um aluno e um funcionário de cada uma das doze escolas da rede, sendo realizada no período de agosto a novembro de 2014. As categorias foram apresentadas através de gráficos para melhor compreensão dos resultados da pesquisa. Considera-se que se faz necessário desenvolver um trabalho cotidiano e sistemático que possibilite aos diferentes agentes envolvidos no cotidiano educacional uma reflexão sobre os princípios que tangem à gestão democrática, para que o projeto político pedagógico seja construído coletivamente.
Carvedilol Plus NUC for Patients With HBV-Compensated Cirrhosis Under Virological Suppression: A Randomized Open-Label Trial
Authors: Wang Bingqiong , Zhou Jialing , Wu Xiaoning , Sun Yameng , Li Lei , Li Ping , Li Minghui , Jiang Wei , Xu Mingyi , Feng Bo , Xu Xiaoyuan , Cheng Jilin , Xie Wen , Han Tao , Wang Xiaozhong , Li Hai , Piao Hongxin , Zhao Xinyu , Chen Shuyan , Meng Tongtong , Guan Qiushuang , Meng Fandong , Kong Yuanyuan , Ou Xiaojuan , Jia Jidong , You Hong
Published: November 2023

INTRODUCTION:

Portal hypertension progression can be relieved after controlling the etiology of liver cirrhosis. Whether beta-blockers could additionally enhance the effects during treatment, particularly for small esophageal varices (EV), was unclear. This study aims to assess the efficacy of add-on carvedilol to delay EV progression during anti-hepatitis B virus (HBV) treatment in HBV-related cirrhosis.

METHODS:

This randomized controlled trial enrolled patients with virologically suppressed HBV-compensated cirrhosis and small/medium EV. The participants were randomly assigned to receive nucleos(t)ide analog (NUC) or carvedilol 12.5 mg plus NUC (1:1 allocation ratio). The primary end point was the progression rate of EV at 2 years of follow-up.

RESULTS:

A total of 238 patients (small EV, 77.3%) were randomized into 119 NUC and 119 carvedilol plus NUC (carvedilol [CARV] combination group). Among them, 205 patients (86.1%) completed paired endoscopies. EV progression rate was 15.5% (16/103) in the NUC group and 12.7% (13/102) in the CARV combination group (relative risk = 0.79, 95% confidence interval 0.36–1.75, P = 0.567). Subgroup analysis on medium EV showed the CARV combination group had a more favorable effect in promoting EV regression (43.5% vs 13.1%, P = 0.022) than NUC alone, but not in small cases (P = 0.534). The incidence of liver-related events (decompensation, hepatocellular carcinoma, or death/liver transplantation) within 2 years was similar between the 2 groups (11.2% vs 10.4%, P = 0.881).

DISCUSSION:

The overall results did not show statistically significant differences between the added carvedilol strategy and NUC monotherapy in preventing EV progression in patients with virologically suppressed HBV-compensated cirrhosis. However, the carvedilol-added approach might offer improved outcomes specifically for patients with medium EV (NCT 03736265).
Językowo-kulturowy obraz dziecka w czeskim dowcipie
Authors: Balowska Grażyna
Published: November 2023

Artykuł prezentuje próbę odtworzenia fragmentu językowo-kulturowego obrazu dziecka, jaki został uchwycony w czeskich dowcipach językowych. Teksty te utrwalają obraz dziecka przede wszystkim w wieku przedszkolnym, wczesnoszkolnym i nastoletnim. Zarejestrowane były także pojedyncze przykłady odniesienia do najwcześniejszego okresu życia dziecka – wieku niemowlęcego. Referat prezentuje funkcjonowanie dziecka w trzech typach przestrzeni społecznej: rodzinnej, edukacyjnej i rówieśniczej. Autorka dochodzi do wniosku, że dziecko w dowcipach postrzegane jest oczami dorosłego i w związku z tym podkreślane są z jednej strony takie jego cechy, które stanowią pewien brak w stosunku do dorosłości: mała wiedza o świecie, naiwność, bezradność, niedojrzałość, z drugiej zaś strony takie zachowania, jak lenistwo, wagarowanie, zachowania antyspołeczne.
Obraz cesty v české a polské frazeologii
Authors: Bieleń Jitka
Published: November 2023

Příspěvek je věnován jazykovému ztvárnění obrazu cesty v české a polské frazeologii. Představuje vybrané pohledy na metaforu cesty od historie do současnosti. V obou jazycích jsou analyzovány a srovnávány frazeologismy spojené s jednotlivými fázemi cesty, s jejím počátkem a koncem, trváním, přerušením a různými okolnostmi cesty, z nichž se vynořují významové shody a diference v konotačním stereotypu pojmu cesta v češtině a polštině.
Investigation of KAPTON–PDMS triboelectric nanogenerator considering the edge-effect capacitor
Authors: Keykha Mohsen , Mohammadi Ali
Published: November 2023

Harvesting the dissipated environmental mechanical energy to generate electrical energy is subject of the new research in the field of clean energy. In this paper, a triboelectric nanogenerator based on vertical two-electrode structure was fabricated using KAPTON and PDMS polymers. The nanogenerator outputs were measured and plotted by applying a mechanical vibration with the frequency of 8 Hz. The results indicated the ability of producing a voltage of 3.5 V and a current of 0.025 μA by this nanogenerator. To effectively simulate the performance of the device in different structural and environmental conditions, the ordinary capacitance model of the device was modified considering three effective capacitances. The simulation results showed a very good agreement between calculated and actual outputs when the edge effect capacitor was included in the ordinary model. Finally, based on the corrected model for the nanogenerator, the effect of the environmental conditions on the device output was studied. The innovative point of this text is the investigation of the effect of edge capacitors in the performance of triboelectric nanogenerators, and it has also been tried to collect a collection of studies that I have done in the field of triboelectric nanogenerators.
Improving power plant technology to increase energy efficiency of autonomous consumers using geothermal sources
Authors: Orynbayev Seitzhan , Tokmoldayev Amanzhol , Abdlakhatova Nazym , Zhanpeisova Aizhan , Tumanov Issakul
Published: November 2023

The significance of this study is underscored by the immense potential of binary power plants in the contemporary world. These plants have a pivotal role to play in supplying heat to homes, facilitating greenhouse heating, and supporting air conditioning systems. The purpose of the study is to provide recommendations on eliminating errors in the processes of improving and implementing geothermal plants and analysing their functioning during electricity generation. The analytical method, classification, functional, statistical, synthesis, and others should be noted among the methods used. The features of geothermal plants in Kazakhstan were noted, their differences were analysed, and errors that are made during the operation of power plants to increase the energy efficiency of consumers and the causes of errors were analysed. Uncertainties in the development and their impact on the functioning of geothermal power plants were identified. The practical value lies in the application of the identified results, solving errors in the development and implementation of a binary power plant to improve the energy efficiency of consumers, the reliability of the use of geothermal plants in the region, considering various factors, which will help provide recommendations for the appropriate use of the mechanism.
Study of fractional variable order COVID-19 environmental transformation model
Authors: Zada Mian Bahadur , Rashid Haroon , Shah Kamal , Abdeljawad Thabet
Published: November 2023

In this study, we explore the epidemic spread of the coronavirus using the Caputo fractional variable order derivative as variable order derivative provides a natural extension to classical as well as fractional order derivatives. Using the variable order derivatives in investigation of biological models of infectious diseases is an important area of research in the current time. Using the fixed point technique, we discuss the existence and uniqueness of solution to the corona virus infectious disease 2019 environmental transformation model. In order to demonstrate the existence and novelty of our findings, we examine the results numerically and graphically with the help of Euler’s method. There are several graphs provided that are related to different variable orders.
Hospice Workers in the Pandemic: Re-visioning Self-Care Systemically in a Time of Crisis
Authors: Clarke Rochelle S. , Rambo Anne
Published: November 2023

Hospice workers, along with other health care staff, experienced significant stress and burnout during the COVID-19 pandemic. Most initiatives designed to address this issue focused on top-down ideas about self-care techniques (Martinez et al, 2021). This article describes an alternative approach based on solution-focused and collaborative assumptions, which allowed hospice health care workers to be the experts on their own stressors, and therefore the experts on how to relieve that stress during an unprecedented time.
“An Enlightened Twenty-First Century?”
Authors: Katz Stanley N.
Published: November 2023

A Review Essay of Towards a New Enlightenment: The Case for Future-Oriented Humanities, by Markus Gabriel, Christoph Horn, Anna Katsman, Wilhelm Krull, Anna Luisa Lippold, Corine Pelluchon, and Ingo Venzke. Bielefeld: transcript Verlag, 2022 (published simultaneously in both German and English).
Dynamische Fähigkeiten in emergenten Medientechnologiemärkten
Authors: Zabel Christian , O’Brien Daniel , Natzel Jonathan
Published: November 2023

Dynamische Fähigkeiten (‚Dynamic Capabilities‘) ermöglichen es Firmen, sich auf den Wandel in ihrer Unternehmensumwelt einzustellen. In sich schnell verändernden Umfeldern – wie z. B. in emergenten Medientechnologiemärkten – ist dabei das ‚Sensing‘, also das Erkennen von unternehmerischen Chancen, von großer Bedeutung. Anhand von 14 in Deutschland tätigen Virtual-Reality-Unternehmen wird explorativ untersucht, wie in einem besonders vagen Umfeld – dem Metaverse – die Routinen und Prozesse zur Chancenerkennung gestaltet sind. Auf Basis von 25 Interviews mit kaufmännischen und technischen Entscheidern betrachten wir zudem den Einfluss von Ressourcen/Unternehmensgröße und Geschäftsmodell auf diese Routinen. Die Studie zeigt, dass die Firmen angesichts der hohen Komplexität des Umfelds auf Bricolage-Verhalten zurückgreifen, also mit limitierten Ressourcen flexibel agieren. Soziale Screening-Routinen (wie der Austausch mit anderen Marktteilnehmern und sogar Wettbewerbern) helfen hier, schwer zugängliches (Markt-) Wissen zu erschließen. Durch Routinen wie Experimentieren und Co-Creation (mit Kunden, Lieferanten und sogar Wettbewerbern) kann (vor allem technisches) Wissen generiert und genutzt werden. Die stark kommerziell getriebene Chancenerkennung ist dabei eng mit dynamischen Fähigkeiten zur Chancenergreifung (‚Seizing‘) verknüpft.
Perspektiven der Netzökonomie
Authors: Hess Thomas
Published: November 2023

Stocker, V./Birke, F./Brunekreeft, G./Weiß, H.-G. (Hrsg.): Perspektiven der Netzökonomie ... Pranz, S./Heidbrink, H./Stadel, F./Wagner, R. (Hrsg.): Journalismus und Unternehmenskommunikation …Breyer-Mayländer, T./Horneber, C. (Hrsg.) Change-Strategien in der Medienbranche
Förderung von Journalismus in lokalen und regionalen Kommunikationsräumen am Beispiel von Baden-Württemberg
Authors: Rinsdorf Lars , Kühnle Boris Alexander
Published: November 2023

Der Beitrag zeichnet am Beispiel von Baden-Württemberg nach, welche Förderansätze besonders geeignet erscheinen, um Qualität und Vielfalt im Journalismus effektiv zu fördern. Der Schwerpunkt liegt auf der lokalen und regionalen Ebene. Die Autoren plädieren für agile Förderstrategien, die transdisziplinäre Gründerteams in den Mittelpunkt rücken.
Reportage-Formate von funk als„journalistische Grenzgänger“
Authors: Mayer Anna-Theresa
Published: November 2023

Der öffentlich-rechtliche Rundfunk und seine Rolle in der digitalen Medienlandschaft sind derzeit Gegenstand lebhafter Debatten. Wenn es um seine gesellschaftliche Leistung auf digitalen Plattformen geht, wird auch oft auf das Angebot von funk, das Content-Netzwerk von ARD und ZDF, eingegangen. Dabei stehen häufig reichweitenstarke funk-Reportage-Formate wie STRG_F oder reporter im Mittelpunkt. Eine im Mai 2023 veröffentlichte Studie der Otto Brenner Stiftung untersucht genau diese Reportage-Formate und liefert erste quantitative Hinweise auf ihre inhaltliche Gestaltung.
El desarrollo de proyectos en segunda lengua
Authors: Lozada Trimbath Minnie
Published: November 2023

Al reflexionar sobre la manera cómo hemos venido trabajando en la línea de lenguaje en la escuela, los maestros tenemos una serie de interrogantes sobre distintas propuestas de cambio para nuestra práctica docente. En esta oportunidad, vamos a referirnos a un aspecto de la línea mencionada, el componente de segunda lengua (L2) en la educación bilingüe intercultural. Y dentro de esta línea, a la posibilidad de uso de la L2 en proyectos que los alumnos van a desarrollar en la práctica educativa.