bluuebunny/crossref_metadata_2025 huggingface dataset:
Older people and life conditions: analysis from household budget research, Viçosa (MG) Brazil, 2019-2020
Authors: Silva Vania Eugênia da , Teixeira Karla Maria Damiano , Cirino Jader Fernandes
Published: April 2022

Abstract Objective The study aimed to identify the socioeconomic profile of the older population in Viçosa, MG, Brazil, and their living condition and verify the influence of the age, sex and education factors on the income of family members and the older people in particula Methods This is a cross-sectional and descriptive study, based on data from the Household Budget Survey (POF) (2019-2020), from the Department of Economics at the Federal University of Viçosa (DEE-UFV). Three hundred and seven households participated in the study and the sample was composed by 167 older people. Results Most of the older people were female, with an average age of 69.8 (±8.07) years old, education level referring to complete high school and retired (74.90%). As to their income, most of them had R$2,914.10 on average, which is above the range considered low by the Brazilian Government Registry named “Cadastro Único”. They also had the retirement as their exclusive income. The older people were satisfied with their living conditions, especially in regard to housing. The variables gender, age, and education influenced the family members’ income. But the age factor did not influence the older people’s income when it was singularly analyzed. Conclusions The studied sample had more satisfactory and favorable income, schooling and living conditions than the older population in the country when compared to studies that used data from the national POF. However, this reality could be linked to the existence of the UFV in the city where great part of the population studies and/or works therefore achieving better educational levels and earning higher incomes once education has a positive impact on the access to better jobs and wages.
Doenças crônicas não transmissíveis considerando determinantes sociodemográficos em coorte de idosos
Authors: Silva Diego Salvador Muniz da , Assumpção Daniela de , Francisco Priscila Maria Stolses Bergamo , Yassuda Mônica Sanches , Neri Anita Liberalesso , Borim Flávia Silva Arbex
Published: April 2022

Resumo Objetivo Analisar as diferenças entre as proporções de doenças crônicas não transmissíveis (DCNT), em dois momentos, em uma coorte de idosos a partir de determinantes sociodemográficos. Método Trata-se de estudo longitudinal retrospectivo com dados obtidos do Estudo FIBRA linha de base (2008-2009) e seguimento (2016-2017). O teste de McNemar foi utilizado para comparar as frequências de DCNT segundo sexo, idade e escolaridade, com nível de significância de 5% (p<0,05). Resultados A amostra foi composta por 453 idosos (idade média 72±5,2 anos; 69,4% do sexo feminino). Observou-se aumento nas proporções de hipertensão arterial (64,4% versus 71,1%) e diabetes mellitus (21,9% versus 27,5%) no período estudado, e redução nas de doença reumatológica (43,6% versus 35,8%) e depressão (21,7% versus 15,7%). A hipertensão aumentou no sexo feminino, e nos idosos com 65-74 anos e com baixa escolaridade; o diabetes aumentou nos idosos do sexo masculino e nos indivíduos com idade acima de 65 anos e com baixa escolaridade; observou-se redução das proporções de doenças reumatológicas e de depressão no decorrer do estudo nas mulheres, naqueles com 65-74 anos de idade e com nível mais baixo de escolaridade. Conclusão Os dados refletem a necessidade de compreensão dos determinantes sociodemográficos de saúde envolvidos no processo saúde-doença-cuidado para a redução de iniquidades sociais e da carga de DCNT nos segmentos populacionais mais vulneráveis, especialmente na população idosa com multimorbidade.
O Programa de Educação pelo Trabalho para a Saúde/Interprofissionalidade: experiências de uma acadêmica de Medicina
Authors: Sousa Elisabete D’Oliveira Paula , Chagas Magda de Souza
Published: April 2022

Resumo: Introdução: Quando se pensa em estratégias que possibilitem a consolidação de um sistema de saúde que leve em consideração o caráter dinâmico, diverso e complexo que a comunidade apresenta, a educação interprofissional mostra-se como uma ferramenta de grande potência na formação de futuros profissionais capazes de exercer um trabalho colaborativo. Nesse contexto, o Programa de Educação pelo Trabalho para a Saúde ganha destaque ao possibilitar a troca de saberes entre acadêmicos de distintos cursos. Relato de experiência: Utilizou-se como ferramenta a narrativa de eventos vivenciados pela acadêmica de Medicina estagiária bolsista do Programa de Educação pelo Trabalho para a Saúde/Interprofissionalidade, integrada ao Consultório na Rua de uma cidade do Rio de Janeiro. Essa integração possibilitou o exercício da interprofissionalidade no campo prático, experiência que não se limitou à interação com o médico do serviço, embora fosse igualmente valiosa essa convivência, mas que levou também à troca com trabalhadores com distintas formações profissionais e discentes de outros cursos. Discussão: Para que o trabalho colaborativo ocorra, não bastam trabalhadores dividindo o mesmo espaço; nessa ótica, faz-se necessária a discussão acerca dos efeitos da educação interprofissional na formação acadêmica, despertando nesses alunos o desejo de trabalhar colaborativamente e preparando-os para o desafio de atender às necessidades e demandas dos usuários do Sistema Único de Saúde. Conclusão: Nas universidades brasileiras, são poucas ainda as atividades que têm como fio condutor a educação interprofissional, entretanto esse tipo de educação possui potência para aproximar o graduando das realidades a serem enfrentadas no cotidiano de sua futura prática profissional, pautado no processo ensino-aprendizagem com indivíduos de diferentes formações profissionais, de modo que o trabalho colaborativo se torne um facilitador na oferta à comunidade de um serviço de saúde de alta qualidade.
The Education through Work Program for Health/Interprofessionality: experiences of a Medical student
Authors: Sousa Elisabete D’Oliveira Paula , Chagas Magda de Souza
Published: April 2022

Abstract: Introduction: When considering strategies that allow the consolidation of a health system that takes into account the dynamic, diverse and complex characteristics presented by the community, interprofessional education appears as a powerful tool in the training of future professionals, capable of carrying out collaborative work. In this context, the Education through Work Program for Health is highlighted by allowing the exchange of knowledge between students from different courses. Experience report: The narrative of events experienced by the medical student intern with a scholarship from the Education through Work Program for Health/Interprofessionality was used as a tool, integrated to the “Consultório na Rua” (“Street Office”) in a city of Rio de Janeiro, an integration that allowed the exercise of interprofessionality in the practical field, an experience that was not limited to interaction with the service physician, although this coexistence was equally invaluable, but which also led to exchanges with workers with different professional backgrounds and students from other courses. Discussion: For the collaborative work to occur, it is not enough for workers to share the same space; from this perspective, it is necessary to discuss the effects of interprofessional education on academic training, awakening in these students the desire to work collaboratively and preparing them for the challenge of meeting the needs and demands of the Unified Health System users. Conclusion: In Brazilian universities, there are still few activities that are guided by interprofessional education; however, this type of education has the power to bring the student closer to the realities to be faced in the daily life of their future professional practice, based on the teaching-learning process with individuals from different professional backgrounds, so that collaborative work becomes a facilitator when offering the community a high-quality health service.
Sleep bruxism in children and its association with clinical and sleep characteristics: cross-sectional study
Authors: ALVES Eliezer Gomes , FAGUNDES Daniela Malagoni , FERREIRA Meire Coelho
Published: April 2022

ABSTRACT Objective: The aim of the present study was to evaluate the prevalence of bruxism in children and its association with clinical and sleep characteristics. Methods: The study sample composed of 239 children aged 7 to 10 years enrolled in a public and a private school in the city of São Luís (MA). Bruxism was investigated based on parental reports of teeth grinding at night, sleep quality, and both intraoral and extraoral clinical aspects related to the condition. Data analysis involved descriptive statistics, Pearson’s chi-squared (c2) test, the linear trend c2 test, and Fisher’s exact test with a 5% significance level. Results: The prevalence of bruxism was 19.7%. Among the children with bruxism, 17% had poor sleep quality, 44.1% slept up to nine hours per night, 82.2% had daytime sleepiness, and 17.9% felt tiredness or pain in the facial muscles upon waking. Conclusions: Based on the present findings, the prevalence of sleep bruxism was significant. No significant associations were observed with the factors investigated, although daytime sleepiness was found to be the most prevalent characteristic of bruxism.
Full-mouth ultrasonic debridement in the treatment of patients with diabetes and severe chronic periodontitis: preliminary study
Authors: MEIRA Ana Luísa Teixeira , NOBRE Camila , NASCIMENTO Maísa CARDOZO , NAPIMOGA Marcelo , CASARIN Renato , BITTENCOURT Sandro , DEL PELOSO RIBEIRO Érica
Published: April 2022

ABSTRACT Objective: The purpose of this study was to clinically evaluate the effect of one-stage full-mouth ultrasonic debridement in the treatment of diabetic subjects with severe chronic periodontitis. Methods: Sixteen patients with uncontrolled diabetes (glycated hemoglobin ≥ 7%) and severe chronic periodontitis (at least 8 teeth with a probing depth and bleeding on probing were selected and randomly assigned to 2 treatment groups: control group (n=7) - quadrant-wise scaling and root planning; test group (n=9) - full-mouth ultrasonic debridement in one session of 45 minutes. The following outcomes were assessed: plaque index, gingival index, bleeding on probing, probing depth, clinical attachment level and gingival margin position. All parameters were assessed at baseline, 1 and 3 months after treatment. Probing depth, clinical attachment level and gingival margin position were analyzed using ANOVA and Tukey test, and the other clinical parameters analysed with the Friedman and Mann-Whitney tests. Results: An improvement in probing depth, clinical attachment level was observed after treatment in both groups, but without statistically significant differences between them. After 3 months, in initially deep pockets, the PD decreased 1.6 mm and 1.7 mm in test and control group, respectively. Clinical attachment level gain ≥ 2 mm was statistically significant at sites in control (10.1%) and test (13,4%) groups in 3 months. Conclusions: One-stage full-mouth ultrasonic debridement promoted similar clinical outcomes to those obtained with the scaling and root planning in the treatment of diabetic subjects with severe chronic periodontitis.
DO DIÁRIO DE FORMAÇÃO À SISTEMATIZAÇÃO DA EXPERIÊNCIA: O PROCESSO DE (AUTO)FORMAÇÃO DE PROFESSORES DE CIÊNCIAS
Authors: BREMM DANIELE , GÜLLICH ROQUE ISMAEL DA COSTA
Published: April 2022

RESUMO: No presente artigo buscamos compreender como ocorre o processo de autoformação de Professores de Ciências e como este processo está relacionado com o Diário de Formação, a escrita de narrativas reflexivas e com a Sistematização de Experiências, mecanismos desencadeados pela Investigação-Formação-Ação. Realizamos uma pesquisa de abordagem qualitativa com base em 15 Diários de Formação de Professores de Ciências em formação continuada, analisados à luz da Análise Textual e Discursiva. Os resultados apontam para a compreensão do Diário de Formação como Espaço de Sistematização e Ressignificação das Experiências, foram encontrados indícios de que o processo de formação de professores é ocasionado por meio do avanço reflexivo sobre as práticas e sobre a própria formação, sendo essa investigação possibilitada pelo processo de Sistematização de Experiências. Defendemos a relevância da Investigação-Formação-Ação em coletivos de formação de Professores de Ciências, sendo o Diário de Formação e a Sistematização de Experiências elementos potencializadores do desenvolvimento da reflexão crítica e autoformação docente.
FROM THE FORMATION DIARY TO THE SYSTEMATIZATION OF EXPERIENCE: THE PROCESS OF (SELF)FORMATION OF SCIENCE TEACHERS
Authors: BREMM DANIELE , GÜLLICH ROQUE ISMAEL DA COSTA
Published: April 2022

ABSTRACT: In this article we seek to understand how the self-training process of Science Teachers takes place and how this process is related to the Formation Diary, the writing of reflective narratives and the Systematization of Experiences, mechanisms triggered by the Research-Formation-Action. We carried out a qualitative approach research based on 15 Formation Diary of Science Teachers in continued education, analyzed on the light of Textual and Discursive Analysis. The results point to the understanding of the Formation Diary as a Space for Systematization and Resignification of Experiences, evidence was found that the process of teacher education is brought about through the reflective advance on practices and on their own formation, and this investigation is made possible by the process of Systematization of Experiences. We defend the relevance of the Research-Formation-Action in collectives for the formation of Science Teachers, with the Formation Diary and the Systematization of Experiences being potentiating elements for the development of critical reflection and teacher self-formation.
Teorias do Estado e a Teoria Novo-Desenvolvimentista
Authors: Bresser-Pereira Luiz Carlos
Published: April 2022

RESUMO Este artigo visa fazer uma resenha sistemática das teorias do Estado e atualizá-la para integrá-la na economia política da Teoria Novo-Desenvolvimentista. Adotando um critério aproximadamente cronológico, classifica as teorias do Estado segundo a tradição orgânico-republicana, a tradição liberal-contratualista, a tradição marxista, a tradição desenvolvimentista e as teorias do aparelho do Estado. Dá ao Novo um espaço um pouco maior porque essa abordagem teórica está sendo desenvolvida com a participação do autor. O artigo apresenta os principais autores que contribuíram para cada teoria, o método adotado, seu caráter autoritário ou democrático, e suas principais características. Os autores falecidos aparecem com sua data de seu nascimento e de sua morte.
The mechanical and durability indices for mortar containing crushed waste oyster shells
Authors: Liao Yingdi , Liu Xinyi , Zhao Yazhou , Shen Chun , Zhang Yan , Chen Da
Published: April 2022

To better assess the safety of cementitious materials containing crushed waste oyster shells (WOS), the workability, mechanical properties (compressive strength and static elastic modulus) and durability (volume of permeable void (VPV), water absorption (WA) and total charge passed) were studied. The effects of replacing river sand with different content of crushed WOS (0, 10, 20 and 30%) on flowability, mechanical properties and durability of mortar have been revealed. The results indicated that the addition of WOS had a significant effect on the flow table of the mortar, and the loss ratio of FT varied from 25% to 39% at 120 min. Although the compressive strength (fc), static elastic modulus (Ec) and apparent density gradually decreased with the increase of WOS content, the mechanical properties were improved by prolonging the curing time. The incorporation of crushed WOS in mortar increased the VPV and WA, as well as the transport properties of mortar. The replacement of natural river sand with crushed WOS greatly increased the drying shrinkage of mortar. The substituted ratio–Gardner model exhibited the best accuracy in predicting the drying shrinkage development of crushed WOS mortar.
Feuer aus? Weimars «Aschebücher» und die Resilienz der Überlieferung
Authors: Laube Reinhard
Published: April 2022

Am 2. September 2004 erhitzte sich in der Herzogin Anna Amalia Bibliothek ein defektes Elektrokabel und löste zunächst einen Schwelbrand aus. Der führte schließlich zu einem verheerenden Feuer, dessen bis zu zwanzig Meter hohe Flammen im Nachthimmel über Weimar weithin zu sehen waren. Die zweite Galerie des Rokokosaales und das Mansardgeschoss mit der Dachkonstruktion des Gebäudeabschnitts «Grünes Schloss» wurden zerstört; rund 50 000 Bände sowie Möbel und Kunstwerke verbrannten nahezu vollständig, 118 000 Bände wurden beschädigt geborgen. Dem größten Bibliotheksbrand in Deutschland nach dem Zweiten Weltkrieg folgte ein beispielloser Wiederaufbau von Gebäude und Sammlungen, der auf zivilgesellschaftlichem Engagement ebenso beruhte wie auf dem Einsatz öffentlicher Mittel.
Orgon auf dem Scheiterhaufen. Der Fall Wilhelm Reich
Authors: Gehring Petra
Published: April 2022

Ein mehrfach vertriebener Immigrant, Arzt und Psychoanalytiker, charismatischer Intellektueller, exzentrischer Lebemann, standespolitischer Hitzkopf, ein dazu äußerst erfolgreicher Grundlagenforscher wird von US-Behörden zum Staatsfeind erklärt. Sie verdächtigen ihn, jagen ihn, bespitzeln seine Arbeit. Schließlich wird dem Mann mittels gerichtlicher Verfügungen das experimentierende Forschen verboten, er wird ins Gefängnis gebracht und so letztlich in den Tod getrieben. Zuvor brennen Unterlagen und Bücher.
Aus der Enzyklopädie der scholastischen Leidenschaften
Authors: Rexroth Frank
Published: April 2022

Als George Steiner in den 1970er Jahren ihr Ende ausrief, wussten seine Leser nicht recht, ob sie jubeln oder jammern sollten: Die bookishness, jene Eigenart von Büchermenschen, für die die deutsche Sprache keinen richtigen Ausdruck bereithält. Sie war eine zweischneidige Sache, wozu also trauern? Hatten die von ihr Befallenen nicht die Eigenschaft, Gelesenes für die Wirklichkeit zu nehmen, Dinge für wahrhaftig zu halten, nur weil sie mit einem Fußnotenbeleg versehen waren? So liebenswürdig kauzig man Leseratten auch finden mag – bookish knowledge, dieses Produkt «gelehrter Stallfütterung» (G. Chr. Lichtenberg), stand und steht auch heute nicht hoch im Kurs.
The Effect of Augmented Reality Experience on Loyalty and Purchasing Intent: An Application on the Retail Sector
Authors: ERU Oya , TOPUZ Yusuf Volkan , COP Ruziye
Published: April 2022

Due to mobile applications have become popular in marketing activities, many retail businesses have begun to launch their Augmented Reality (AR) applications. The application of AR technology to marketing is a very new process. When businesses create interactive channels through which they can reach consumers, they can influence the purchasing decision processes of consumers. In addition, companies aim to provide consumers with an unforgettable shopping experience. The study’s research question was, “How do consumers' innovativeness and AR experiences affect their loyalty and purchase intentions? Also, innovativeness has a significant effect on their AR application use intentions. This study investigates the impact of innovativeness and AR experience on consumer loyalty and purchase intention. Based on the assumption that the importance of AR applications in marketing activities will gradually increase, it can be said that examining the effects of AR applications on consumer attitudes and behaviours is gaining reputation. Studies investigating the impact of augmented reality applications are very limited in the consumer behaviour literature. This situation shows the original value of the study. In the application part of the study, a quantitative research design was used. In this context, the convenience sampling method was selected. Data were collected from 319 participants via an online questionnaire, and the responses obtained were analysed using a structural equation model. The results showed that the AR experience had been affected positively by the innovation dimension, while consumer loyalty was affected positively by the AR experience.
TURKEY S ROLE IN SILK ROAD ROUTES: ENERGY SUPPLY SECURITY OF EUROPEAN UNION AFTER UKRAINE – RUSSIAN WAR
Authors: Toraman Yavuz
Published: April 2022

Purpose- The aim of the research is to examine, analyze and provide insight into possible future projections of Turkey's role in the security of energy supply and the formation of new trade routes of the European Union (E.U.) after the Ukraine-Russia war within the scope of data obtained from experts. In addition, the current research has been understood that the EastMed project has reached a stalemate with Turkey's Exclusive Economic Zone (EEZ) agreement with Libya and has emerged due to the necessity of new solutions. In addition, turkey's strong position is mentioned, emphasizing that it is an important stakeholder in world politics and trade.
Methodology- Since research requires expertise in a particular field, it is determined according to the purpose and scope of the research to be carried out with a specific focus group. The experts in the focus group were reached by the snowball sampling method. In this context, an in-depth interview technique from qualitative data analysis methods was carried out to a group of experts in international relations, international trade, and logistics departments. The research data were obtained from the faculty members and faculty members included in the group between 28.02.2022-09.03.2022 through Google Docs, and the analysis process was started.
Findings- When the data obtained from the experts included in the research are examined, the perspective against the Tr-Med project, which is the recommendation of the research, is very positive. One reason is that the EastMed project is already known to be unsustainable, and in addition, the United States has withdrawn its support from the project. It can also be seen as the E.U.'s production of alternatives to existing energy supply processes in order to ensure energy supply security after the Ukraine-Russia war. In addition to the Tr-Med project, it is foreseen that the main routes of east-west-axis trade will shift to Turkey due to future sanctions against Russia.
Conclusion- Turkey is foreseen to continue their union in the future because it is already a stakeholder of the E.U. in the TANAP project, has a partner in imports and exports, and is an actor who will play a role in the process of establishing relations with countries such as Iran, Israel, Egypt, Lebanon, Syria, and Qatar in the supply of energy supplies. However, the increase in freight prices in the post-COVID-19 period increased transportation costs, and in addition, the increase in raw material prices caused global inflation. With the Ukraine-Russia war, the price of crude oil at $130, experts say, will see $300 in oil in the future, which will make Turkey the E.U.'s manufacturing hub.

Keywords: Energy security, pipeline, Eastern Mediterranean, naturel gas, Silk Road, one belt and one road ınitiative
JEL Codes: F4, L8, N4
COVID-19 vaccine uptake and intention during pregnancy in Canada
Authors: Reifferscheid Laura , Marfo Emmanuel , Assi Ali , Dubé Eve , MacDonald Noni E. , Meyer Samantha B. , Bettinger Julie A. , Driedger S. Michelle , Robinson Joan , Sadarangani Manish , Wilson Sarah E. , Benzies Karen , Lemaire-Paquette Samuel , Gagneur Arnaud , MacDonald Shannon E.
Published: April 2022

Objective

To investigate COVID-19 vaccine uptake and intent among pregnant people in Canada, and determine associated factors.

Methods

We conducted a national cross-sectional survey among pregnant people from May 28 through June 7, 2021 (n = 193). Respondents completed a questionnaire to determine COVID-19 vaccine acceptance (defined as either received or intend to receive a COVID-19 vaccine during pregnancy), factors associated with vaccine acceptance, and rationale for accepting/not accepting the vaccine.

Results

Of 193 respondents, 57.5% (n = 111) reported COVID-19 vaccine acceptance. Among those who did not accept the vaccine, concern over vaccine safety was the most commonly cited reason (90.1%, n = 73), and 81.7% (n = 67) disagreed with receiving a vaccine that had not been tested in pregnant people. Confidence in COVID-19 vaccine safety (aOR 16.72, 95% CI: 7.22, 42.39), Indigenous self-identification (aOR 11.59, 95% CI: 1.77, 117.18), and employment in an occupation at high risk for COVID-19 exposure excluding healthcare (aOR 4.76, 95% CI: 1.32, 18.60) were associated with vaccine acceptance. Perceived personal risk of COVID-19 disease was not associated with vaccine acceptance in the multivariate model.

Conclusion

Vaccine safety is a primary concern for this population. Safety information should be communicated to this population as it emerges, along with clear messaging on the benefits of vaccination, as disease risk is either poorly understood or poorly valued in this population.
A refined phase diagram of the GeTe-Bi2Te3 system
Authors: Алекперова Туркан Музагим , Мейер Ханс-Юрген , Оруджлу Эльнур Наджаф , Бабанлы Магомед Баба
Published: April 2022

Updated phase diagram of the GeTe–Bi2Te3 system was constructed using differential thermal, X-ray diffraction analysis and scanning electron microscopy (SEM) results of alloys synthesized with specially developed technology. The refined version significantly differs from those reported so far. The presented phase diagram reflects six ternary compounds: Ge4Bi2Te7, Ge3Bi2Te6, Ge2Bi2Te5, GeBi2Te4, GeBi4Te7, and GeBi6Te10.         The study determined that the first two compounds are formed as a result of solid-state reactions at temperatures of 750–800 K, and the latter four are formed as a result of peritectic reactions at 863, 854, 848, and 843 K, respectively. Wide homogeneity regions based on the initial binary compounds were also found. These regions reach 10 mol% at room temperature. The coordinates of eutectic point are 83 mol% Bi2Te3 and 838 K. It crystallises at 838 К. It was found that all the identified ternary compounds crystallise in a tetradymite-like layered structure. Ge4Bi2Te7, Ge3Bi2Te6, Ge2Bi2Te5, and GeBi2Te4 compounds belong to the nGeTe·Bi2Te3 homologous series. Their crystal lattices are formed by the insertion of GeTe bilayers into the quintuple Bi2Te3 layers. GeBi4Te7 and GeBi6Te10 compounds are representatives of the GeTe·mBi2Te3homologous series and have a mixed-layer structure. The parameters of the crystal lattices of the compounds were determined by the Rietveld method based on their powder diffraction data.
Preparation and characterisation of cobalt and cobalt-zinc ferrites for magnetorheological materials
Authors: Гайдук Юлиан Станиславович , Коробко Евгения Викторовна , Котиков Дмитрий Анатольевич , Свито Иван Антонович , Усенко Александра Евгеньевна , Паньков Владимир Васильевич
Published: April 2022

The aim of this study was to study the structure, morphology, magnetic, and magnetorheological properties of cobalt and cobalt-zinc ferrite powders to be used as a functional component of magnetorheological fluids.           Ferrites of cobalt CoFe2O4 and cobalt-zinc Co0.65Zn0.35Fe2O4 were obtained by combined hydrolysis of inorganic metal salt in aqueous solutions followed by thermal treatment of the precipitates. The ferrites were studied by means of X-ray phase analysis, scanning electron microscopy, IR spectroscopy, and magnetometry.         The synthesised ferrites are polydispersed powders with the size of primary particles of 300–400 nm and the size of the coherent scattering regions of 22–33 nm. They demonstrate a high shear stress in  magnetorheological suspensions, which is 2.5 times higher than that of the nanosized particles. High-temperature annealing results in a significant increase in the specific magnetisation of the powders, as well as the shear stress in suspensions prepared on their basis. Doping cobalt ferrite with zinc leads to an increase in the specific magnetisation and rheological characteristics.          The studied materials have a high shear stress in suspensions (~ 2.5 kPa at 650 mT) and can be used as functional fillers for magnetorheological materials.
Polycondensation in a spray of aqueous-alcoholic solution of lactic acid
Authors: Федосеев Виктор Борисович , Федосеева Елена Николаевна
Published: April 2022

The removal of low molecular weight products of the reaction and heat withdrawal is one of the problems of bulk polycondensation. Polycondensation under spray conditions is an effective way to solve these problems.      Based on the example of the reversible reaction of lactic acid polycondensation, it was shown that size effects can significantly affect the conversion rate, the degree of polymerization, and the rate of processes. Chemical thermodynamics suggests that chemical equilibrium in a spray shifts towards the formation of polylactide. In addition, the recondensation of volatile components (water, lactic acid, solvent) stabilizes the concentration of reagents and the temperature in the spray drops throughout the entire process. Model experiments confirming the obtained regularities are presented. Microscopic observation of sessile drops of aqueous and aqueous-alcoholic lactic acid solutions demonstrated the formation of polylactide under normal conditions (without heating, catalyst, evacuation).
Structural and magnetic properties of Ho-doped CuFe2O4 nanoparticles prepared by a simple co-precipitation method
Authors: Хоанг Бао Ханг , Миттова Валентина Олеговна , Нгуен Ань Тьен , Фам Тхи Хонг Зуен
Published: April 2022

Nanocrystalline copper (II) ferrite with a spinel structure doped with holmium was synthesized by co-precipitation using an aqueous solution of NaOH as a precipitant and subsequent annealing at 800°C for 60 min. The doping limit was determined by X-ray phase analysis. The similarity of the real and nominal compositions of the doped samples was established by energy-dispersive X-ray spectroscopy using a scanning electron microscope. The obtained particles had an approximately spherical shape, and their size was 40–70 nm (X-ray phase analysis, transmission electron microscopy). The introduction of Ho3+ cations to х = 0.15 into a CuFe2O4 spinel lattice led to a decrease in the average size of crystallites, an increase inthe coercive force of nanopowders, and a decrease in excess magnetization and saturation magnetization. Synthesized CuFe2-xHoxO4 (х = 0, 0.1 and 0.15) nanopowders were magnetically hard materials with high coercive force.
Salter vs Pemberton: Comparative Radiologic Analysis of Changes in the Acetabulum and Pelvis After Surgical Correction in Children with Hip Dysplasia
Authors: Bortulev Pavel I. , Baskaeva Tamila V. , Vissarionov Sergei V. , Barsukov Dmitry B. , Pozdnikin Ivan Yu. , Kozhevnikov Vadim V.
Published: April 2022

Background. Hip dysplasia, characterized by pronounced anatomical changes, continues to be one of the leading positions in the structure of all congenital malformations of the musculoskeletal system. Late diagnosis or ineffective conservative treatment leads to the need for surgical correction of congenital deformities of the proximal femur and acetabulum. The choice of the method of operational reconstruction of the latter remains a subject of discussion over the past decades.
Aim of the study a comparative X-ray analysis of surgical treatment outcomes of children with hip dysplasia type IHDI IIIIV after Salter and Pemberton pelvic osteotomies.
Methods. The study included 80 patients (80 hip joints) aged 2 to 4 years (3.10.45) with hip dysplasia of the IIIIV degree according to the IHDI. Patients were divided into two groups: group I consisted of 40 patients who underwent modified Salter osteotomy, group II 40 patients who underwent Pemberton pericapsular acetabuloplasty. Radiometry of the following parameters was performed: acetabular index (AI), Wiberg angle, neck-shaft angle, anteversion angle of the proximal femur, degree of bone coverage, the depth of the acetabulum (AD) and pelvic height (PH)
Results. The values of AI and Wiberg angle in patients in I group indicate that a greater correction was achieved (p0.05) in contrast to patients who underwent Pemberton pericapsular acetabuloplasty. At the same time, the values of AD and PH in I group patients had pronounced differences (p0.05) from those in II group patients, whose values were close to similar indicators in the contralateral hip joint.
Conslusions. In the treatment of children with hip dysplasia IHDI III-IV degree performing a modified Salter osteotomy leads to a significant decrease in the values of AI and an increase in the values of the Wiberg angle, which corresponds to hypercorrection of the position of the acetabulum, does not affect the AD and contributes to the elongation of the hemipelvis by an average of 13.8 mm. Pemberton acetabuloplasty allows to achieve values of AI and Wiberg angle close to the age-related indicators of the norm, leads to an increase AD, approaching the contralateral joint in its value and does not significantly affect the PH.
Molecular mechanisms of drug resistance of glioblastoma. Part 1: ABC family proteins and inhibitors
Authors: Chernov Alexander N. , Shamova Olga V.
Published: April 2022

The most common high-grade brain tumor in the adult population is glioblastoma. The life expectancy of patients with this tumor does not exceed 12-15 months, while relapses are observed in 100% of cases. One of the main reasons for the low efficiency of glioblastoma therapy is its multidrug resistance. In the development of the latter, transporter proteins of the ABC family play a key role. In this part, the emphasis is on the search for new molecular targets among growth factors, their receptors, signal transduction kinases, microRNAs, transcription factors, protooncogenes, and tumor suppressor genes involved in the regulation of proteins and genes of the ABC family and associated with the development of multidrug resistance in glioblastoma cells. The review also discusses the mechanisms of the cytotoxic action of inhibitors: ABC family proteins, tyrosine kinase receptors, non-receptor tyrosine kinases, vascular endothelial growth factor, kinases of signaling cascades, transcription factors, histone deacetylases, methyltransferases, replication and synthesis of DNA, microtubules and proteasome used in glioblastoma therapy or undergoing clinical trials.
Features of the intestinal microbiota composition in multiple sclerosis patients receiving oral disease-modifying therapy
Authors: Tarasova Elena A. , Lioudyno Victoria I. , Matsulevich Anna V. , Negoreeva Irina G. , Ilves Aleksandr G. , Ivashkova Elena V. , Shkilnyuk Galina G. , Abdurasulova Irina N.
Published: April 2022

BACKGROUND: Heterogeneous dysbiosis of the intestinal microbiome is a common hallmark of multiple sclerosis. In this pilot study, we compared the level of some gut bacteria in multiple sclerosis patients receiving oral disease-modifying therapy versus untreated.
MATERIALS AND METHODS: Subjects were patients with relapsing-remitting or secondary and primary progressive multiple sclerosis. Multiple sclerosis patients were treated by Fingolimod (n = 31), Teriflunomide (n = 21) or were untreated (n = 31). The bacterial levels in stool samples were analyzed by cultivation method and real time PCR.
RESULTS: The levels of symbiotic and opportunistic bacterial species in the fecal samples of multiple sclerosis patients receiving disease-modifying therapy were different from those in untreated patients. Also, there was a difference in the spectrum of gastrointestinal tract disorders between these patients. Fingolimod-treated patients showed decreased levels of some bacterial species compared to untreated subjects, including Escherichia coli with regular enzymatic activity, Sutterella wadsworthensis (phylum Proteobacteria), butyrate-producing bacteria Roseburia spp., Faecalibacterium prausnitzii, and Ruminococcus spp. (phylum Firmicutes, class Clostridia). Teriflunomide-treated patients demonstrated decreased levels of Lactobacillus spp. and Enterococcus spp. (phylum Firmicutes, class Bacilli) and Ruminococcus spp. Increased levels of Bifidobacterium spp. were observed in treated and untreated multiple sclerosis patients with higher EDSS scores.
CONCLUSIONS: This study shows the negative effect of oral disease-modifying therapy on intestinal microbiota composition and gastrointestinal tract disorders. However, more extensive studies are needed to confirm these preliminary results and develop ways to normalize intestinal dysbiosis in multiple sclerosis patients.
Crustal Structure across the West Antarctic Rift System from Multicomponent Ambient Noise Surface Wave Tomography
Authors: Dylan Mikesell Thomas , Mordret Aurélien , Xu Zongbo , Frank William B.
Published: April 2022

Approximately 2 yr (2010–2011) of continuous seismic records from a subset of the Antarctic component of the Polar Earth Observing Network (POLENET-ANET) seismic network deployed in West Antarctica are used to compute the nine components of the correlation tensor between each pair of stations in the network. Rayleigh wave velocity information from the vertical and radial components was extracted in the form of group and phase velocity dispersion curves, whereas the transverse component provided complimentary Love wave velocity information. The multicomponent Rayleigh wave measurements (ZZ, RR, ZR, and RZ) were averaged and used to infer the measurement uncertainties. The Rayleigh and Love wave group and phase velocities were then regionalized in space using a 2D deterministic tomography. A transect that spans the West Antarctic rift system was extracted from the tomography at individual periods between 7 and 60 s for the four types of surface wave velocities (i.e., Rayleigh and Love phase and group velocities). A transdimensional Bayesian joint inversion algorithm was used to invert these four datasets for a 1D model of isotropic shear-wave velocity versus depth at each point along the transect. In this way, surface wave dispersion curves from multicomponent noise correlations were used to build a 2D isotropic shear-wave velocity model down to ∼55 km depth. In this model, the top of the large low-velocity zone beneath Marie Byrd Land was imaged (up to a 5% decrease in velocity at ∼50 km depth), which provides further evidence for a mantle hot spot beneath the crust that supports the high topography in this region. We also observed a large velocity contrast in the lower crust beneath Marie Byrd Land at a depth where previous long-period seismicity has been observed. This strong contrast occurs more shallow than in previous crustal models, which compared to our model identify a deeper Moho (∼5–10 km deeper) beneath Marie Byrd Land. This new model has implications for interpreting earthquake locations in this region and perhaps necessitates that we revisit past hypocenter estimation studies using updated velocity models for the region.
Hyperosmolarity disrupts tight junction via TNF-α/MMP pathway in primary human corneal epithelial cells
Authors:   Eye Centre, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China; School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Zhang Yun , Zhao Shi-Xin ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Nie Li ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Shen Li-Jun ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Han Wei ,   Eye Centre, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Published: April 2022

AIM: To investigate the mechanism of the tight junction (TJ) disruption and the association between tumor necrosis factor (TNF)-α and matrix metalloproteinase (MMPs) under hyperosmotic condition in primary human corneal epithelial cells (HCECs).
METHODS: The cultured HCECs were exposed to media which adding sodium chloride (NaCl) for hyperosmolar stress or adding rh-TNF-α (10 ng/mL). NF-κB inhibitor (5 μmol/L) or GM-6001 (potent and broad spectrum MMP inhibitor, 20 μmol/L) was added 1h before that treatment. The integrity of TJ proteins was determined by immunofluorescent (IF) staining. The mRNA levels of TNF-α and MMPs were evaluated by quantitative reverse transcription polymerase chain reaction (RT-qPCR) and the protein expression by enzyme-linked immunosorbent assay (ELISA).
RESULTS: TJ proteins ZO-1 and Occludin were disrupted in primary HCECs exposed to hyperosmotic medium. The mRNA expression and protein production of TNF-α increased significantly in hyperosmotic media at 500 mOsM. TNF-α mediated the expression and production of MMP-1, MMP-13, MMP-9, and MMP-3 stimulated by hyperosmotic stress. The production of MMPs in hyperosmolar media were increased through the increase of TNF-α. GM-6001 prevent the destruction of ZO-1 and Occludin in hyperosmolar stress and rh-TNF-α treated medium. TNF-α induced activation of MMPs was involved in the TJ disruption by hyperosmolarity.
CONCLUSION: TJ proteins ZO-1 and Occludin are disrupted by hyperosmolar stress and TNF-α, but protected by MMP inhibitor (GM-6001). It suggests that TNF-α/MMP pathway mediates the TJ disruption in primary HCECs exposed to hyperosmotic stress.
Comparison of preoperative simulated and postoperative real safety distances using anterior segment OCT in patients with phakic IOL according to iris configuration
Authors:   Research Department, Oftalmosalud Institute of Eyes, San Isidro, Lima 27, Perú, Henriquez Maria A , Ben-Shaul Or ,   Research Department, Oftalmosalud Institute of Eyes, San Isidro, Lima 27, Perú, Jr Luis Izquierdo ,   Research Department, Oftalmosalud Institute of Eyes, San Isidro, Lima 27, Perú
Published: April 2022

AIM: To compare the simulated safe distance (SSD) preoperatively versus real safe distance (RSD) postoperatively in patients with iris-claw phakic intraocular lens (pIOL) implantation according to iris configuration.
METHODS: Totally 60 eyes of 60 patients underwent pIOL implantation for surgical correction of myopia. Anterior chamber depth (ACD) was measured with the IOLMaster 700, and nasal and temporal safety distances (SD) were measured pre- and postoperatively using Anterior Segment Visante-OCT. SD was defined as a line measured between the edge of the optic or its simulated image to the endothelium. Eyes were divided into 3 groups: convex, concave, and plane according to preoperatory iris configuration. Statistical analysis was performed using the R program, for the comparison of independent groups and multiple comparisons, the Kruskal-Wallis test and the Dunn test were used respectively.
RESULTS: Mean difference between nasal preoperative SSD and postoperative RSD was -0.36±0.38, -0.29±0.48, and -0.18±0.30 mm in the concave, convex, and plane group, respectively. Mean difference between temporal SSD and RSD was -0.36±0.37, -0.14±0.38, and -0.24±0.33 mm in the concave, convex, and plane group, respectively. There were statistically significant differences between SSD and RSS for both nasal and temporal sides in the concave and plane group (P<0.002).
CONCLUSION: Preoperative SSD and postoperative RSD for iris-claw pIOL shows significant differences in patients with concave and plane iris.
Green tea—a new perspective of glaucoma prevention
Authors:   Vilnius University Faculty of Medicine, Vilnius 03101, Lithuania, Gasiunas Kornelijus
Published: April 2022

AIM: To determine how green tea and catechins can affect intraocular pressure (IOP) changes.
METHODS: Totally 43 young volunteers were included in the study. The experiment was held between noon and 2 p.m. Two extracts—green tea and epigallocatechin gallate (EGCG, 400 mg capsules) and placebo (400 mg capsules) were used in the study. Participants were divided into three groups. Green tea extract group (GT group) had 17 subjects, EGCG extract group 17 subjects, control (placebo) group 9 subjects. IOP was measured with the Icare tonometer before and 30min, 1, 1.5, 2h after the consumption of each extract and placebo. Results were analyzed using the IBM SPSS program. Statistical confidence level P<0.05.
RESULTS: The most significant reduction of IOP from the beginning of the experiment was measured after 2h in GT group (left 2.18±3.19 mm Hg, P=0.012; right 2.59±1.97 mm Hg, P<0.000) and after 1h in EGCG extract group (left 2.41±2.98 mm Hg, P<0.004; right 1.94±1.98 mm Hg, P<0.001). In control group no significant changes were measured.
CONCLUSION: People who have increased IOP or risk factors for glaucoma development, could benefit from drinking green tea or its concentrated extracts in moderate doses.
Effects of anti-TNF biologic drugs on uveitis severity in Behcet patients: systematic review and Meta-analysis
Authors:   Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5756115111, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia 5756115111, Iran, Abolhasani Somayeh , Hosseini Foroogh ,   Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran, Aziz Shiva Gholizadeh-Ghaleh ,   Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5756115111, Iran, Alipour Shahriar ,   Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia 5756115111, Iran; Student Research Committee, Urmia University of Medical Sciences, Urmia 5756115111, Iran
Published: April 2022

AIM: To investigate effects of anti-TNF biologic drugs on uveitis severity (comparing visual acuity logMAR levels) in Behçet patients.
METHODS: Three databases PubMed, Scopus, and the Web of Science were searched for qualified papers focusing on the anti-TNF-α factors treatment in Behçet’s disease (BD)-associated uveitis. Studies that were designed pre and post anti-TNF drug treatment, were selected. After determining the search strategy for this study, the relevant data were extracted.
RESULTS: The initial search was performed in the target databases and a total of about 1458 articles were found. Fifteen articles were selected for systematic review and only 12 of them had inclusion criteria for Meta-analysis (with visual acuity data). The mean dose of prednisolone before and after biological treatments was reported in 5 studies (28.56 and 7.56 mg/kg, respectively). Also, the preliminary results indicate a significant reduction in visual acuity logMAR levels (MD=-1.5 IU/L, 95%CI: -2.1, -0.01).
CONCLUSION: Biological drugs significantly reduce the dose of prednisolone and affect visual acuity values.
Upper Cretaceous deposits on the Northern side of the High Atlas Range of Marrakesh (Morocco): tectonics, sequence stratigraphy and paleogeographic evolution
Authors: Algouti Ahmed , Algouti Abdellah , Hadach Fatiha , Farah Abdelouhed , Aydda Ali
Published: April 2022

This paper presents a new interpretation of the paleogeographic evolution of the northern side of the High Atlas Range of Marrakesh (Morocco) based on a tectonic, lithological, sedimentological, and paleontological description of the three outcropping Upper Cretaceous Formations: The Anou-Nfeg Formation, the Aït Abbes Formation, and the Chichaoua Formation. In biostratigraphical terms, these formations areas signed to the Coniacian, Santonian, and Maastrichtian, respectively, and record three tectonic phases responsible for the geodynamic evolution of this part of the High Atlas Range. These phases are confirmed by the vertical elevation of the earth’s surface and the formation of some small restricted basins. A sedimentary pause corresponding to the Campanian has been recorded. Based on these findings, we conclude that these Formations were deposited in a confined environment influenced by the episodic marine incursions under a hot and humid climate.