bluuebunny/crossref_metadata_2025 huggingface dataset:
Redução da força de preensão manual entre idosos longevos
Authors: Tavares Darlene Mara dos Santos , Oliveira Nayara Gomes Nunes , Marchiori Gianna Fiori , Santos Lara Lacerda Soares
Published: November 2020

Objetivos: Descrever as características sociodemográficas e de saúde dos longevos, identificar a ocorrência da redução da força de preensão manual dos longevos e verificar os fatores associados à redução da força de preensão manual dos longevos. Métodos: Estudo transversal e analítico, com abordagem quantitativa, desenvolvido com 313 idosos longevos da comunidade de uma Macrorregião de Saúde do Estado de Minas Gerais. Na coleta dos dados aplicaram-se: Miniexame do Estado Mental; Questionário estruturado elaborado pelo Grupo de Pesquisa em Saúde Coletiva; Questionário Internacional de Atividade Física; versão brasileira do Short Physical Performance Battery; Teste de força de preensão manual; Índice de massa corporal e questão referente à ocorrência de queda. Procederam-se às análises: descritiva, teste Qui-quadrado e regressão logística múltipla (p<0,05). Resultados: Houve predomínio de longevos do sexo feminino (64,2%); com 80-90 anos de idade (86,6%); 1-5 anos de estudo (53,0%); renda ≤1 salário mínimo (55,3%); viúvos (63,3%); que moravam acompanhados (75,7%); inativos fisicamente (51,4%); com desempenho físico moderado/bom (55,9%); sem ocorrência de quedas nos últimos 12 meses (68,4%); eutróficos (39,9%) e com cinco ou mais morbidades (62,9%). A maioria dos longevos (60,4%) apresentou redução da força de preensão manual que se associou à ocorrência de quedas nos últimos 12 meses (p=0,042) e à inatividade física (p<0,001). Conclusão: A redução na força de preensão manual dos idosos longevos foi relacionada à ocorrência de quedas e inatividade física, tais fatores contribuem para planejamento do cuidado gerontológico na prática clínica.
Trained Immunity in Atherosclerotic Cardiovascular Disease
Authors: Flores-Gomez Daniela , Bekkering Siroon , Netea Mihai G. , Riksen Niels P.
Published: November 2020

Atherosclerosis is characterized by incessant inflammation in the arterial wall in which monocytes and macrophages play a crucial role. During the past few years, it has been reported that cells from the innate immune system can develop a long-lasting proinflammatory phenotype after brief stimulation not only with microbial products but also endogenous atherogenic stimuli. This persistent hyperactivation of the innate immune system is termed trained immunity and can contribute to the pathophysiology of atherosclerosis. Trained immunity is mediated via epigenetic and metabolic reprogramming and occurs both in mature innate immune cells as well as their bone marrow progenitors. In addition to monocytes, other innate immune and nonimmune cells involved in different stages of atherosclerosis can develop comparable memory characteristics. This mechanism provides exciting novel pharmacological targets that can be used to prevent or treat cardiovascular diseases.
Gal-1 (Galectin-1) Upregulation Contributes to Abdominal Aortic Aneurysm Progression by Enhancing Vascular Inflammation
Authors: Chiang Ming-Tsai , Chen I-Ming , Hsu Fu-Fei , Chen Yen-Hui , Tsai Min-Shao , Hsu Yaw-Wen , Leu Hsin-Bang , Huang Po-Hsun , Chen Jaw-Wen , Liu Fu-Tong , Chen Ying-Hwa , Chau Lee-Young
Published: November 2020

Objective:

Abdominal aortic aneurysm (AAA) is a vascular degenerative disease causing sudden rupture of aorta and significant mortality in elders. Nevertheless, no prognostic and therapeutic target is available for disease management. Gal-1 (galectin-1) is a β-galactoside–binding lectin constitutively expressed in vasculature with roles in maintaining vascular homeostasis. This study aims to investigate the potential involvement of Gal-1 in AAA progression.

Approach and Results:

Gal-1 was significantly elevated in circulation and aortic tissues of Ang II (angiotensin II)–infused apoE-deficient mice developing AAA. Gal-1 deficiency reduced incidence and severity of AAA with lower expression of aortic MMPs (matrix metalloproteases) and proinflammatory cytokines. TNFα (tumor necrosis factor alpha) induced Gal-1 expression in cultured vascular smooth muscle cells and adventitial fibroblasts. Gal-1 deletion enhanced TNFα-induced MMP9 expression in fibroblasts but not vascular smooth muscle cells. Cysteinyl-labeling assay demonstrated that aortic Gal-1 exhibited susceptibility to oxidation in vivo. Recombinant oxidized Gal-1 induced expression of MMP9 and inflammatory cytokines to various extents in macrophages, vascular smooth muscle cells, and fibroblasts through activation of MAP (mitogen-activated protein) kinase signaling. Clinically, serum MMP9 level was significantly higher in both patients with AAA and coronary artery disease than in control subjects, whereas serum Gal-1 level was elevated in patients with AAA but not coronary artery disease when compared with controls.

Conclusions:

Gal-1 is highly induced and contributes to AAA by enhancing matrix degradation activity and inflammatory responses in experimental model. The pathological link between Gal-1 and AAA is also observed in human patients. These findings support the potential of Gal-1 as a disease biomarker and therapeutic target of AAA.
Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers
Authors: Kim Joanna , Cooper John A.
Published: November 2020

Objective:

Septin 2 is localized at junctions in human microvascular endothelial monolayers. The junctional localization of septin 2 is necessary for organization of cell-cell adhesion proteins of endothelial cells.

Approach and Results:

Septin 2 was depleted at junctions by suppression of expression using shRNA, treatment with inflammatory cytokine, TNF (tumor necrosis factor)-α, and ectopic overexpression of septin 2 phosphatidylinositol 4,5-bisphosphate binding mutant defect in interaction with plasma membrane. Under those conditions, organizations and expression levels of various junctional proteins were analyzed. Confocal images of immunofluorescence staining showed substantial disorganization of adherens junctional proteins, nectin-2 and afadin, TJP (tight junction protein), ZO (zonula occludens)-1, and intercellular adhesion protein, PECAM-1 (platelet-endothelial cell adhesion molecule-1). Immunoblots for those proteins did not show significant changes in expression except for nectin-2 that highly increased in expression. Significant differential gene expression profiles and biological pathway analysis by septin 2 suppression and by TNF-α treatment using RNA-seq showed common overlapping pathways. The commonalities in expression may be consistent with the similar effects on the overall organization of cell-cell adhesion proteins.

Conclusions:

Localization of septin 2 at cell junctions are required for the arrangement of junctional proteins and the integrity of the barrier formed by endothelial monolayers.
Identifying with a Religious Character
Authors: Soto-Sanfiel María T. , Mäder Marie Therese
Published: November 2020

This study examines the extent to which audience’s identification with a religious character relates to variables of the message, the cultural setting in which it is consumed, and the viewer. Four hundred and eight students from Spanish (Mean
Age = 20.36, SD = 3.24) and Swiss universities (Mean
Age = 22.16, SD = 2.76) were assigned to one of two narratives portraying a religious character (Mormon or Muslim). Before watching the film, they completed a questionnaire (gender, age, religious background, religious affiliation, religiosity, and spirituality). After the viewing, they indicated their identification with the character from the film. Results show that identification relates to the religion portrayed and the cultural context in which the film is viewed. Individuals with a personal link to religion identify to a greater extent. Moreover, individuals associate aspects of their spirituality and religiosity to dimensions of identification depending on the religion portrayed. The cultural setting impacts this association.
Nomenclatural adjustments in Brazilian Cereeae (Cactaceae)

Authors: TAYLOR NIGEL P. , ZAPPI DANIELA C.
Published: November 2020

Recent taxonomic activity has resulted in taxa belonging to Cactaceae tribe Cereeae from limestone outcrops in Eastern Brazil being upgraded as a species and genus, respectively: Melocactus pachyacanthus Buining & Brederoo  (1975: 1) subsp. viridis N.P. Taylor (1991: 40) and Pilosocereus Byles & Rowley (1957: 66) subg. Gounellea Zappi (1994: 36). However, two of the new names associated with these changes have proved to be either illegitimate or invalid under the rules of the International Code of Nomenclature for plants and fungi (Turland et al. 2018). The following notes provide legitimate or valid names for the taxa involved.
Combining Radar Attenuation and Partial Beam Blockage Corrections for Improved Quantitative Application
Authors: Gou Yabin , Chen Haonan
Published: November 2020

Partial beam blockage (PBB) correction is an indispensable step in weather radar data quality control and subsequent quantitative applications, such as precipitation estimation, especially in urban and/or complex terrain environments. This paper developed a novel PBB correction procedure based on the improved ZPHI method for attenuation correction and regional specific differential propagation phase (KDP)–reflectivity (ZH) relationship derived from in situ raindrop size distribution (DSD) measurements. The practical performance of this PBB correction technique was evaluated through comparing the spatial continuity of reflectivity measurements, the consistency between radar-measured and DSD-derived KDP and ZH relationships, as well as rainfall estimates based on R(ZH) and R(KDP). The results showed that through incorporating attenuation and PBB corrections (i) the spatial continuity of ZH measurements can effectively be enhanced; (ii) the distribution of radar-measured KDP versus ZH is more consistent with the DSD-derived KDP versus ZH; (iii) the measured ZH from a C-band radar in the PBB-affected area becomes more consistent with collocated S-band measurements, particularly in the rainstorm center area where ZH is larger than 30 dBZ; and (iv) rainfall estimates based on R(ZH) in the PBB-affected area are incrementally improved with better spatial continuity and the performance tends to be more comparable with R(KDP).
Clinical Factors Associated With Response to Fecal Diversion in Crohn’s Disease
Authors: Buhulaigah Hassan , Truong Adam , Zaghiyan Karen , Fleshner Phillip
Published: November 2020

Up to 80% of Crohn’s disease (CD) patients require surgery. Fecal diversion is used selectively in CD proctocolitis refractory to medical treatment or advanced perianal disease. This study examines associations between clinical features in predicting clinical response (CR) to fecal diversion in CD. Charts of CD patients undergoing fecal diversion for medically refractory disease or perianal disease were reviewed. Clinical response was assessed focusing on improvements in urgency, abdominal and perineal pain, decreased anal fistula drainage, and weight gain. Univariate binary logistic regression and multivariate forward-stepwise modeling analysis were used to determine associations with CR. The study cohort comprised 79 patients. After a median follow-up of 36 (3-192) months, 40 (51%) patients achieved a CR. Binary logistic regression analysis revealed both age at diagnosis (hazard ratio [HR] 1.05; confidence interval [CI] 1.01-1.09; P = .007) and disease duration (HR .91; CI .86-.96; P = .001) to be significantly associated with CR. Later age of onset (HR 1.05; CI 1.01-1.10; P = .002) and shorter disease duration (HR .91; CI .86-.97; P = .02) remained significant on multivariate analysis. This largest reported series of fecal diversion for refractory CD in the biologic drug era revealed that young age at diagnosis and long disease duration are associated with a lower CR.
Retrospective Review of Preoperative Wire Localization for Peripheral Ground Glass Opacities
Authors: Merchant Natalie N. , McKenna Robert , Sier Rachel , Onugha Osita
Published: November 2020

Video-assisted thoracoscopy (VATS) is performed for diagnosis and treatment of peripheral lung nodules. Localization of peripherally located ground-glass opacities (GGOs) can be challenging. We report the results and usefulness of preoperative computed tomography (CT)-guided wire localization. Records for patients who underwent CT-guided wire localization prior to VATS resection for peripherally located GGOs were analyzed. Our technique for targeting the GGOs, complications, and histopathology of GGOs is reviewed. Forty patients (mean age 68 years) underwent pulmonary resections following CT-guided wire localization. The mean diameter of the GGO was 11.0 mm. The mean distance from the pleural surface to the peripheral margin of the GGO was 18.6 mm. Complications from the wire localization included pneumothorax in 5 patients (12.5%), none of whom required insertion of a chest tube; parenchymal hemorrhage in 3 patients (7.5%); and pleural effusion requiring chest tube drainage (unrelated to the wire) in 1 patient (2.5%). The mean operative time was 74 (range: 21-186 ) minutes. Pathological examination revealed lung malignancy in 36 patients (90%). The diagnostic yield was 100%. Preoperative CT-guided wire localization for solitary or multiple peripherally located GGOs allows for determination of histopathologic diagnosis and high diagnostic yield.
The Effects of Tier 2 Mathematics Interventions for Students With Mathematics Difficulties: A Meta-Analysis
Authors: Jitendra Asha K. , Alghamdi Ahmed , Edmunds Rebecca , McKevett Nicole M. , Mouanoutoua John , Roesslein Rachel
Published: November 2020

This meta-analysis examined the effectiveness of supplemental Tier-2 mathematics interventions for students with mathematics difficulties (MD). We reviewed 39 experimental and quasi-experimental studies that included 40 independent samples, with 61 treatment groups. Utilizing robust variance estimation (RVE), results revealed a treatment effect of 0.41. Mixed-effects meta-regression analyses revealed that Tier-2 interventions were moderated by intervention model type, group size, and type of measure. We present recommendations for future research and implementation of mathematics practices.
The Supply Chain Disruption Framework Post COVID-19: A System Dynamics Model
Authors: Sinha Deepankar , Bagodi Virupaxi , Dey Debasri
Published: November 2020

The COVID pandemic seems to have raised the question, ‘whether existing supply chain (SC) disruption philosophies and strategies continue to remain valid?’. This article assesses the differences in the business scenarios pre-and post-COVID. The authors capture the mathematical and operational relationships amongst the relevant factors and propose a System Dynamics (SD) model to carry out the simulations. The approach considers the impact of the force majeure condition, that is, COVID period on individuals’ income, prices and demand of goods, cost of input and supply of finished goods. The results show that earnings may increase demand but, disruption in supplies of raw materials and finished products nullify the effect. On the other hand, even if flow returns to normal, reduced income affects normal goods businesses.

JEL Codes: R41
Prevalence and correlates of psychological distress among a national population-based sample of adults in Solomon Islands
Authors: Pengpid Supa , Peltzer Karl
Published: November 2020

Background:

Psychological distress is an undersearched cause of poorer health in the Pacific island countries.

Aims:

The study aimed to investigate the prevalence and associated factors of psychological distress in a population-based survey among 18–69 year-old persons in Solomon Islands.

Method:

Cross-sectional nationally representative data of 2,533 18–69 year-old persons (38 years were the median age) from the 2015 Solomon Islands STEPS survey were analysed.

Results:

The results indicate that 18.9% of participants had psychological distress (⩾20 scores), 13.4% had mild (20–24 scores), 4.3% moderate (25–29 scores) and 1.1% severe (30–50 scores) psychological distress. In adjusted logistic regression analysis, being divorced, separated, or widowed (AOR: 2.76, 95% CI: 1.60–4.78), having had a heart attack or stroke (AOR: 3.34, 95% CI: 2.23–4.99), alcohol dependence (AOR: 1.72, 95% CI: 1.04–2.84), and sedentary behaviour (AOR: 1.90, 95% CI: 1.28–2.84), were positively and the consumption of 3–4 servings of fruit and vegetables (AOR: 0.62, 95% CI: 0.42–0.92), were negatively associated with psychological distress (⩾20 scores). In addition, in a sex stratified adjusted logistic regression analysis among men, current smokeless tobacco use (AOR: 4.95, 95% CI: 1.66–14.75), was associated with psychological distress. Furthermore, in the overall unadjusted analysis, stop smoking attempts in the past 12 months and consumption of too much salt was associated with psychological distress.

Conclusion:

Almost one in five participants were reported psychological distress and several factors were detected which could be targeted in intervention activities.
Reflections on conducting qualitative school-based research with children: A research note
Authors: Fitzgerald Caitríona
Published: November 2020

This research note offers a critical reflection of the process of conducting qualitative research in the Irish primary school setting. The research discussed took place during the school year 2016–2017. It explored primary school children’s understandings of citizenship and, the kinds of collective social actions they participated in as citizens and peers at school. I reflect upon this in terms of my experiences of gaining and maintaining access in Irish primary schools. I also draw attention to social and cultural contexts within the research setting and the influence this has over data collection. I aim to offer some useful insights into the process of conducting qualitative research within formal education settings and, to encourage conversation between researchers and educators to find solutions to issues associated with conducting research in schools.
The Reasons People Think About Staying and Leaving Their Romantic Relationships: A Mixed-Method Analysis
Authors: Machia Laura V. , Ogolsky Brian G.
Published: November 2020

Across three studies (total N = 993) with diverse methodologies (i.e., experimental studies, longitudinal in vivo sampling), we found that there are distinct reasons why individuals believe their romantic relationship will become, or did become, less committed, and reasons why individuals believe their relationships will become, or became, more committed. Whereas the strongest endorsed reasons to stay (e.g., satisfaction) are the same as the strongest endorsed reasons to leave (e.g., dissatisfaction), there are many constructs that are more strongly endorsed as either leave reasons (e.g., quality of alternatives) or stay reasons (e.g., love). These reasons are important glimpses into the process that occurs when someone is deciding whether to stay or leave a relationship, and results empirically confirm a core tenet of Interdependence Theory that until now has been only theoretical (i.e., some outcomes contribute more motivation to staying in the current relationship, whereas others contribute more motivation to leaving).
Nationalism and the strength of secessionism in Western Europe: Static and dynamic autonomy
Authors: Lecours André
Published: November 2020

Contrary to the dominant expectations of the late 20th century, secessionism surged in two West European minority national communities, Catalonia and Scotland, over the last decade. Yet, in two others enjoying similar degrees of autonomy, Flanders and South Tyrol, secessionism did not gain strength. This outcome suggests that focusing on the degree of autonomy afforded to minority national communities is misplaced. This article shows that the nature of autonomy is more important than its degree for understanding the strength of secessionism. It demonstrates that the key to autonomy regimes weakening secessionism is their capacity to adjust and expand over time. Dynamic autonomy staves off secessionism while static autonomy stimulates it. The article is based on a controlled comparison of, on the one hand, Catalonia and Scotland, where autonomy regimes have been mostly static during key periods of time, and, on the other hand, Flanders and South Tyrol, where they have been dynamic.
Pathways to Family Violence: Investigating Patterns in the Event Process of Family Violence Perpetrators
Authors: Stairmand Meg , Dixon Louise , Polaschek Devon L. L.
Published: November 2020

This study is part of a larger research project that developed the event process model of family violence (FVEPM). The FVEPM was developed by applying grounded theory methods to the event narratives of 14 men and 13 women completing community-based family violence (FV) perpetrator treatment programs. The current study extends this work with the original sample, by examining the routes individual events take through the FVEPM. Three main pathways—comprising 93% of event narratives—were identified: a conflict escalation pathway ( n = 14), an automated violence pathway ( n = 6), and a compliance pathway ( n = 6). Our findings extend existing FV typologies and theories by identifying patterns of features pertaining to the individual, the relationship, and the situation that converge to result in FV perpetration during a FVE. Further validation and development of the pathways may provide FV practitioners with an organizing framework from which to identify more nuanced assessment, treatment planning, and risk management processes for the diverse range of FV perpetrators they are tasked with treating.
Whistleblowing Motivation and Gender: Vignette-Based Study in a Local Government
Authors: Prysmakova Palina , Evans Michelle D.
Published: November 2020

Public administration literature has been building more evidence about whistleblowing and gender, and whistleblowing and public service motivation. Yet, despite the well-developed theoretical argument of the socialization effect on public service motivation and gender, little effort has been undertaken to study their simultaneous relationships with whistleblowing. This study fills this gap suggesting that whistleblowing mechanisms for the public sector should allow no room for gender differences and should guarantee equal access to the procedure. A constant-variable-value vignette study conducted with 799 respondents from a large local government in Poland reveals strong gender effects, that overshadow previously supported positive association between public service motivation and corruption reporting. Namely, despite the confirmed positive association between PSM levels and whistleblowing intentions, highly public service motivated women are less inclined to report a misconduct of their supervisors than men. The socialization context relevant to the study location is discussed in the conclusion.
Assessment of Pediatric Pseudotumor Cerebri Clinical Characteristics and Outcomes
Authors: Yamamoto Erin , Farber Darren , Rothner David , Moodley Manikum
Published: November 2020

Pseudotumor cerebri also known as idiopathic intracranial hypertension is a relatively uncommon disorder of unknown pathophysiology. Although pseudotumor cerebri occurs in both children and adults, the pseudotumor cerebri literature is heavily dominated by adult studies. The aim of this study is to retrospectively describe the clinical presentation, imaging, treatment, and outcomes of a large pediatric pseudotumor cerebri population over a 23-year period. We also discuss secondary pseudotumor cerebri (44%) as well as the increasingly recognized patient subgroups without headache (13.3%) and without papilledema (7.3%). Female sex, obesity, and initial symptoms were consistent with the literature; however radiographic findings were surprisingly low in this cohort. Headache outcomes at 1 week, 1 month, and 3 months following initial lumbar puncture/treatment and visual function outcomes are reported.
B-Lines Scores Derived From Lung Ultrasound Provide Accurate Prediction of Extravascular Lung Water Index: An Observational Study in Critically Ill Patients
Authors: Mayr Ulrich , Lukas Marina , Habenicht Livia , Wiessner Johannes , Heilmaier Markus , Ulrich Jörg , Rasch Sebastian , Schmid Roland M. , Lahmer Tobias , Huber Wolfgang , Herner Alexander
Published: November 2020

Introduction:

Visualization of B-lines via lung ultrasound provides a non-invasive estimation of pulmonary hydration. Extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) assessed by transpulmonary thermodilution (TPTD) represent the most validated parameters of lung water and alveolocapillary permeability, but measurement is invasive and expensive. This study aimed to compare the correlations of B-lines scores from extensive 28-sector and simplified 4-sector chest scan with EVLWI and PVPI derived from TPTD in the setting of intensive care unit (primary endpoint).

Methods:

We performed scoring of 28-sector and 4-sector B-Lines in 50 critically ill patients. TPTD was carried out with the PiCCO-2-device (Pulsion Medical Systems SE, Maquet Getinge Group). Median time exposure for ultrasound procedure was 12 minutes for 28-sector and 4 minutes for 4-sector scan.

Results:

Primarily, we found close correlations of 28-sector as well as 4-sector B-Lines scores with EVLWI (R2 = 0.895 vs. R2 = 0.880) and PVPI (R2 = 0.760 vs. R2 = 0.742). Both B-lines scores showed high accuracy to identify patients with specific levels of EVLWI and PVPI. The extensive 28-sector B-lines score revealed a moderate advantage compared to simplified 4-sector scan in detecting a normal EVLWI ≤ 7 (28-sector scan: sensitivity = 81.8%, specificity = 94.9%, AUC = 0.939 versus 4-sector scan: sensitivity = 81.8%, specificity = 82.1%, AUC = 0.902). Both protocols were approximately equivalent in prediction of lung edema with EVLWI ≥ 10 (28-sector scan: sensitivity = 88.9%, specificity = 95.7%, AUC = 0.977 versus 4-sector scan: sensitivity = 81.5%, specificity = 91.3%, AUC = 0.958) or severe pulmonary edema with EVLWI ≥ 15 (28-sector scan: sensitivity = 91.7%, specificity = 97.4%, AUC = 0.995 versus 4-sector scan: sensitivity = 91.7%, specificity = 92.1%, AUC = 0.978). As secondary endpoints, our evaluations resulted in significant associations of 28-sector as well as simplified 4-sector B-Lines score with parameters of respiratory function.

Conclusion:

Both B-line protocols provide accurate non-invasive evaluation of lung water in critically ill patients. The 28-sector scan offers a marginal advantage in prediction of pulmonary edema, but needs substantially more time than 4-sector scan.
Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering
Authors: Ahmadi Mahsa , Mehdikhani Mehdi , Varshosaz Jaleh , Farsaei Shadi , Torabi Hadis
Published: November 2020

In this study, gelatin/hyaluronic acid (HA) scaffolds containing different amounts of atorvastatin-loaded nanostructured lipid carriers (NLCs) coated entirely with polycaprolactone (PCL) film were fabricated for skin regeneration. 12 atorvastatin-loaded NLCs formulations were synthesized, and particle size, zeta potential, drug entrapment efficiency (EE), and drug release of the formulations were determined. The optimum freeze-dried atorvastatin-loaded NLCs were added in 3 different weight percentages to the gelatin and HA membranous scaffolds. Thereafter, the membranes were coated entirely by a thin layer of the PCL. They were characterized, and then mechanical properties, in vitro degradation and in vitro drug release were assessed. Moreover, human dermal fibroblasts (HDF) were cultured on the prepared nanocomposite scaffolds in order to investigate the cytotoxicity by the MTT assay after the first day, third day, and fifth day. Results revealed that the most favorable atorvastatin-loaded NLCs had 99.54 nm average particle size, −24.30 mV zeta potential, 97.98% EE, and 75.24% drug release within 237 hrs. Mechanical tests indicated that all the three scaffolds had approximately a 90 MPa elastic modulus which was more than two-fold of tensile modulus of normal human skin. The in vitro degradation test demonstrated that the membranes were degraded up to 98% after 5 days, and the scaffolds drug release efficiency (DRE) was in a range of 75–79% during those 5 days. The MTT assay results confirmed the cytocompatibility of the scaffolds. The scaffold containing 54.1 wt% NCLs was the optimum sample (S3). Scanning Electron Microscopy (SEM) images of the latter one showed the uniform distribution of the NLCs with an average size of 150 nm, and the images of cultured HDF illustrated the good cell attachment. In conclusion, suitable physicochemical and biological properties of the novel gelatin/HA/PCL nanocomposite scaffold containing 54.1 wt% atorvastatin-loaded NLCs (S3) can be a good candidate for skin regeneration.
At Least I’m My Own Boss! Explaining Consent, Coercion and Resistance in Platform Work
Authors: Purcell Christina , Brook Paul
Published: November 2020

Platform work has grown significantly in the last decade. High-profile legal cases have highlighted the grey area which platform work inhabits in terms of the employment relationship and have raised concerns about the quality and conditions of work. Platform operators claim they are neutral intermediaries, yet often control over scheduling and tasks lies with them. This article presents a theoretical framework that integrates macro and micro-level analyses to account for the production of hegemony and playing out of consent, coercion and resistance within platform work. It does so by rearticulating Burawoy’s concept of hegemonic despotism by drawing upon Foucauldian notions of neoliberal governmentality and reasserting the centrality of Gramsci’s work in understanding power and hegemony, in particular the concept of contradictory consciousness and the dialogical contest between hegemonic ‘common sense’ and ‘good sense’, which constitutes our understanding and sense-making in the social world.
Attitude trajectory tracking of quadrotor UAV using super-twisting observer-based adaptive controller
Authors: Chen Ai-Jun , Sun Ming-Jian , Wang Zhen-Hua , Feng Nai-Zhang , Shen Yi
Published: November 2020

The successful implementation of high-level decision algorithm on quadrotor depends on the accurate trajectory tracking performance. In this paper attitude estimation and trajectory tracking control problem of quadrotor unmanned aerial vehicle (UAV) with endogenous and exogenous disturbance are considered, where the lumped disturbance characteristic does not have a probabilistic illustration but instead the dynamics are known to have a bound. The problem is handled by developing disturbance estimator and control strategy. In order to estimate lumped disturbance precisely, a globally finite time stable extended state observer is proposed based on super-twisting algorithm. Stability analysis and observer’s parameters selection rule are discussed by using Lyapunov’s stability theory. The proposed observer strategy achieves accurate observing performance of disturbance without increasing observer’s order, and chattering effect is also reduced by applying super-twisting algorithm. Furthermore, a super-twisting sliding mode control law is proposed to guarantee the asymptotic convergence of the drone’s orientation with respect to the reference. Finally, a numerical study based on simulations is presented to analyze the performance of proposed approach.
Synergistic effect of carbon nanotubes and nano-hydroxyapatite on mechanical properties of polyetheretherketone based hybrid nanocomposites
Authors: Kumar Manjeet , Kumar Rajesh , Kumar Sandeep
Published: November 2020

Hybrid nanocomposites utilize the benefits of properties of different fillers to enhance its desired properties. Polyetheretherketone (PEEK) based hybrid nanocomposites have immense potential applications in aerospace, automobile, high-temperature electrical applications, and medical and health care. The present work is an attempt to improve the elastic modulus, hardness, fracture resistance, and storage modulus simultaneously by reinforcing the PEEK matrix with multiwall carbon nanotubes (MWCNTs) filler and 30 wt.% nano hydroxyapatite (nHA)-MWCNT hybrid filler. The nanocomposites having 0,1,3,5 and 7 wt.% of MWCNTs were fabricated by the Ball Mixing and Compression Molding Method. Customized Die Heater setup was used to ensure uniform heating and cooling during compression molding. The morphology was examined by Field Emission Scanning Electron Microscopy (FESEM) and Energy-Dispersive X-ray Spectroscopy (EDS) and uniform distribution of nano-fillers was observed. The nanoindentation method was adopted to investigate the Static Mechanical Analysis (SMA) and Dynamic Mechanical Analysis (DMA) at varying frequencies of loading, of nanocomposites. At 5 wt.% of MWCNTs, the enhancements in elastic modulus, hardness, fracture resistance, and storage modulus were observed to be 80%, 36%, 32%, and 58% respectively in case of PEEK/(0–7%)MWCNT nanocomposite and 104%, 76%, 16%, and 80% respectively in case of PEEK/30%nHA-(0–7%)MWCNT hybrid nanocomposite. The decrements in loss factor indicated the improvement in elastic behavior of nanocomposites with increasing wt.% of MWCNTs. The elastic modulus of PEEK/30%nHA-5%MWCNT hybrid nanocomposite was observed to be 7.67 GPa, which falls within the range of elastic modulus of the human cortical bone. The results revealed that 5 wt.% of MWCNTs is optimum filler composition for improving the mechanical properties.
Chronic Lateral Ankle Instability: Topical Review
Authors: Aicale Rocco , Maffulli Nicola
Published: November 2020

Chronic ankle instability can result from untreated or badly managed acute lateral ankle ligament injuries. Conservative management is the modality of choice for acute lateral ankle ligament injuries, and operative treatment is reserved for special cases. Failure after strict rehabilitation may be an indication for surgery. Several operative options are available, including anatomic repair, anatomic reconstruction, and tenodesis procedures. Anatomic repair can be performed when the quality of the damaged ligaments permits. Anatomic reconstruction with an autograft or allograft should be considered when the torn ligaments are not adequate. Ankle arthroscopy is a useful adjunct to ligamentous procedures, performed at the time of repair to identify and treat intra-articular conditions that may be associated with chronic ankle instability. Tenodesis techniques are not recommended because of their suboptimal long-term results related to the modification of ankle and hindfoot biomechanics.

Level of Evidence: Level V, expert opinion.
Protective effect of vitrectomy on the course of diabetic retinopathy: A case report
Authors: Iuliano Lorenzo , Corbelli Eleonora , Bandello Francesco , Codenotti Marco
Published: November 2020

Purpose:

To hypothesize the protective role of vitrectomy on the natural course of diabetic retinopathy.

Methods:

Case report.

Results:

A 66-year-old lady with a history of type 1 diabetes mellitus since the age of 10 was referred for evaluation. She received laser treatment in her left eye for proliferative diabetic retinopathy 6 years earlier, while her right eye underwent vitrectomy for retinal detachment 17 years before. Diabetic retinopathy was found to be substantially asymmetrical, as the vitrectomized right eye had only mild macular edema without significant vascular abnormalities, whereas the left eye had a complete confluent panretinal photocoagulation with advanced atrophic macular changes. Other reasons for this asymmetry, such as axial length disparity, carotid circulation impairment, or history of branch retinal vein occlusion, were not identified.

Conclusions:

Vitreous removal, performed for a reason other than diabetic retinopathy, may inhibit the retinal complications often associated with longstanding diabetes. Further clinical studies should be considered to ascertain such evidence.
Viral load Suppression and Associated Factors among HIV Patients on Antiretroviral Treatment in Bulambuli District, Eastern Uganda: A Retrospective Cohort Study
Authors: Wakooko Paul , Gavamukulya Yahaya , Wandabwa Julius N
Published: November 2020

Background:

HIV viral load suppression (VLS) is the most important indicator of successful antiretroviral therapy. In 2016, Bulambuli District started monitoring HIV patients on ART using viral load tests in an effort to meet the third 90 of the UNAIDS 90-90-90 strategy which is VLS. The objective of this study was to determine the progress in Bulambuli District towards achievement of VLS among HIV infected patients on ART and associated factors that affect this programme.

Methods:

A retrospective cohort study design was used. One thousand, one hundred and one medical records of HIV infected patients on ART who attended HIV clinic at Muyembe Health Centre IV from June 2016 to April 2018 were reviewed. A data abstraction tool was used for data collection. Chi Square was used to determine factors associated with VLS and logistic regression was used to determine the magnitude by which the ART and clinical factors influence VLS. Data were summarized using descriptive statistics for categorical variables and by computing proportions, means and standard deviation for continuous variables.

Results:

Of the patients (n = 944, 85.7%) had attained VLS. Adjusting for known confounders, only adherence to ART was a significant predictor of VLS. Individuals with fair adherence (80%-95%) had 2.667 times the odds of VLS, CI = 1.122-9.370, P-value of <.002 compared to individuals with good (>95%) adherence which was used as the reference while those with poor (<80%) adherence had 4.553 times the odds of attaining VLS, CI = 1.31-13.930, P-value of <.001 compared to individuals with good adherence.

Conclusion:

These findings suggest that Bulambuli District, at 85.7% VLS is on track to attaining the third 90 of the 90, 90, 90 global targets by 2020. It further reveals that adherence is the only significant predictor of VLS in the District.
Combinatorial Therapy of High Dose Vitamin C and PARP Inhibitors in DNA Repair Deficiency: A Series of 8 Patients
Authors: Demiray Mutlu
Published: November 2020

Background:

Tumor-specific DNA repair defects are ubiquitous in cancerous tissue, which offers a potential for clinical gain to build on these perturbations. Intravenous high-dose vitamin C (IVC) triggers the formation of hydrogen peroxide (H2O2), which contributes to Fenton chemistry producing hydroxyl radicals (-OH), causing selective damage to DNA. Herein, we evaluated the therapeutic response to IVC and PARP inhibitors (PARPi) in combination in 8 patients with a deficiency of homologous recombination repair system (dHRR) in a 3-year period.

Material and Methods:

Eight patients with progressive stage IV malignancy, who were pre-treated with conventional methods, were admitted to our clinic. Subsequent therapy has included IVC at a dose that was set to be in the range of 1 to 1.5 g/kg, although 1.25 g/kg was dominantly administered. Furthermore, following genomic evaluation, PARPi (niraparib or olaparib or talazoparib) was chosen to be used in combination with IVC which was administered 2 to 4 times a week.

Results:

In the present study, we achieved partial response in 5 patients and complete response in 3 patients. Grade 2 anemia and fatigue toxicities were observed in some cases, while grade 3 toxicity was not found in any of the patients.

Conclusion:

Our 8 patient case study shows that IVC could be a plausible additional therapy for HRR deficiency. Although the single agent PARPi therapy is effective for metastatic disease, an overall survival (OS) advantage has not been demonstrated. Our results suggest that adding IVC can improve PARPi therapy outcomes. To fully endorse the results stated above, combinatorial therapy of intravenous high dose vitamin C and PARP inhibitors needs to be reviewed in broader cohorts of patients.
Improving Accelerometry-Based Measurement of Functional Use of the Upper Extremity After Stroke: Machine Learning Versus Counts Threshold Method
Authors: Lum Peter S. , Shu Liqi , Bochniewicz Elaine M. , Tran Tan , Chang Lin-Ching , Barth Jessica , Dromerick Alexander W.
Published: November 2020

Background

Wrist-worn accelerometry provides objective monitoring of upper-extremity functional use, such as reaching tasks, but also detects nonfunctional movements, leading to ambiguity in monitoring results.

Objective

Compare machine learning algorithms with standard methods (counts ratio) to improve accuracy in detecting functional activity.

Methods

Healthy controls and individuals with stroke performed unstructured tasks in a simulated community environment (Test duration = 26 ± 8 minutes) while accelerometry and video were synchronously recorded. Human annotators scored each frame of the video as being functional or nonfunctional activity, providing ground truth. Several machine learning algorithms were developed to separate functional from nonfunctional activity in the accelerometer data. We also calculated the counts ratio, which uses a thresholding scheme to calculate the duration of activity in the paretic limb normalized by the less-affected limb.

Results

The counts ratio was not significantly correlated with ground truth and had large errors ( r = 0.48; P = .16; average error = 52.7%) because of high levels of nonfunctional movement in the paretic limb. Counts did not increase with increased functional movement. The best-performing intrasubject machine learning algorithm had an accuracy of 92.6% in the paretic limb of stroke patients, and the correlation with ground truth was r = 0.99 ( P < .001; average error = 3.9%). The best intersubject model had an accuracy of 74.2% and a correlation of r =0.81 ( P = .005; average error = 5.2%) with ground truth.

Conclusions

In our sample, the counts ratio did not accurately reflect functional activity. Machine learning algorithms were more accurate, and future work should focus on the development of a clinical tool.
Clinical characteristics associated with sentinel headache in patients with unruptured intracranial aneurysms
Authors: Wan Zheng , Meng Hao , Xu Ning , Liu Tianyi , Chen Zhongping , Sun Yang , Wang Honglei
Published: November 2020

Objective

Sentinel headache (SH) is considered as a signal of the impending rupture of an aneurysm. However, it is difficult to diagnose whether the headaches of patients are associated with unstable aneurysms. Therefore, there is some doubt about the importance of headaches in patients with unruptured intracranial aneurysms (UIAs). This study was performed to explore the existence and clinical characteristics of SH associated with aneurysms.

Methods

Thirty-six patients with a single UIA were collected in this study. Patients were symptomatically categorized into two groups: SH and non-SH. The PHASES scores and patient and aneurysm characteristics were analyzed. Two independent MRI experts who were blinded to the patients’ clinical history conducted the analysis of the SWI results.

Results

There were 15 patients with sentinel headache. No significant difference was found in patient’s basic information and history. The SH group had a higher PHASES score than the non-SH group (P < 0.05). In univariable analysis, abnormal SWI signals were significantly more frequent in the SH group (P < 0.01) and the inflow angle was significantly lower in the non-SH group (P < 0.05). In multivariable analysis, abnormal signals in SWI were an independent factor associated with SH (P < 0.01).

Conclusions

SH exists in patients with UIAs and may indicate a high risk of aneurysm rupture. Abnormal signals on SWI may serve as a clinical feature to identify aneurysm-related SH and be helpful for the formulation of therapeutic strategy. Aneurysm geometry may also be related to SH but need further studies in the future.
Imposed pressure driven flow in peristalsis
Authors: Fatima Ishrat , Asghar Saleem
Published: November 2020

Peristaltic transport phenomena are of great significance in biological sciences. The physiological transport of fluid takes place under the action of peristalsis generated as a pressure gradient. The peristaltic waves generate a pressure gradient which is responsible for the fluid flow in the forward direction. The further properties of this phenomena can be seen if an imposed pressure gradient is applied in addition to the one appearing due to peristaltic waves. This situation has not been discussed in the literature that needs further attention. The effects of the wavy boundaries and imposed pressure on the velocity of the flow field are analyzed. Here we impose a question: what happens if an imposed pressure gradient is also applied? This question of physical importance has not been addressed; and thus, remains the topic of this study. In previous papers of peristaltic motion, the flow generated by peristaltic waves only has been examined while in this study we will discuss the contribution of imposed pressure gradient on velocity field. The analytical results for the velocity field are obtained using the boundary perturbation method. The study shows that the impact of the wavy boundaries on the flow increases with the increase in corrugation parameter and imposed pressure.
Pharmacokinetics and tolerability of LIQ861, a novel dry‐powder formulation of treprostinil
Authors: Roscigno Robert , Vaughn Toby , Anderson Stephanie , Wargin William , Hunt Thomas , Hill Nicholas S.
Published: November 2020

A dry‐powder inhaled formulation of treprostinil (LIQ861) produced using PRINT® technology offers a substantial advantage over current nebulized therapy. Treprostinil is a synthetic prostacyclin analogue that is currently approved for inhalation administration to patients with pulmonary arterial hypertension via nebulized Tyvaso® inhalation solution. LTI‐101 was a phase 1, placebo‐controlled, double‐blind, randomized, single‐center study that evaluated the ascending single‐dose pharmacokinetics of LIQ861 in healthy subjects. Six sequential, escalating doses (25, 50, 75, 100, 125, and 150 mcg) were studied to investigate treprostinil exposure from LIQ861 inhalation. Subjects (n = 57) were randomly assigned in a 3:1 ratio to receive a single dose of either LIQ861 (n = 43) or placebo (n = 14); 56 subjects completed all protocol‐defined assessments. Following single‐dose administration, treprostinil exposure from LIQ861 increased proportionally across the dose range studied, and the pharmacokinetics profile of treprostinil administered as LIQ861 was similar to prior reports of inhaled treprostinil. All doses of LIQ861 were generally well‐tolerated with no deaths, serious adverse events, or dose‐limiting toxicities. The most frequently reported treatment‐emergent adverse events related to study drug administration were coughing and throat irritation, which are common to dry‐powder formulations. Treatment‐related treatment‐emergent adverse events were reported more frequently at higher dose levels; however, all were assessed as mild in severity. We conclude that the pharmacokinetics profile of treprostinil using a dry‐powder inhaled formulation increased in proportion to dose as anticipated and was similar to earlier reports of inhaled, nebulized treprostinil (Tyvaso®). Based on these results, a phase 3 study (INSPIRE; Clinicaltrials.gov Identifier NCT03399604) evaluating the long‐term safety and tolerability of LIQ861 in patients with pulmonary arterial hypertension was initiated.