bluuebunny/crossref_metadata_2025 huggingface dataset:
O ESTUDO DE CASO COMO MÉTODO DE PESQUISA EM ENFERMAGEM: UMA REVISÃO INTEGRATIVA
Authors: Andrade Selma Regina de , Ruoff Andriela Backes , Piccoli Talita , Schmitt Márcia Danieli , Ferreira Alexandra , Xavier Ana Cristina Ammon
Published: November 2017

RESUMO Objetivo: analisar a aplicação do estudo de caso como método de pesquisa pela enfermagem nas publicações científicas nacionais e internacionais. Método: revisão integrativa de literatura realizada nas bases bibliográficas eletrônicas PubMed, CINAHL, LILACS e SciELO, utilizando os descritores estudo de caso, pesquisa e enfermagem. Foram incluídos artigos originais disponíveis na íntegra no formato on-line, nos idiomas português, inglês ou espanhol, no recorte temporal de 2010 a 2015. Resultados: foram encontrados 624 estudos, dos quais 50 atenderam ao objetivo. Os autores Yin e Stake foram os pesquisadores cujos referenciais metodológicos de estudo de caso se destacaram no contexto da pesquisa na área da enfermagem. A aplicação do método abrangeu os diferentes campos de atuação da profissão: educação, assistência/cuidado e gestão/administração. Conclusão: o estudo de caso como método de pesquisa mostrou-se uma importante metodologia que pode ser amplamente utilizada pela enfermagem nos seus diversos campos de atuação ao buscar compreender fenômenos relacionados a indivíduos, grupos ou organizações.
Enzimas degradantes de organofosforados: Base molecular e perspectivas para biorremediação enzimática de agroquímicos
Authors: Castro Alexandre Alves de , Prandi Ingrid Guarnetti , Kuca Kamil , Ramalho Teodorico Castro
Published: November 2017

RESUMO Muitos compostos organofosforados (OP) são utilizados até hoje na agricultura como pesticidas e, infelizmente, como agentes de guerra química (ou agentes dos nervos) também. Os pesticidas organofosforados e os agentes dos nervos são moléculas extremamente tóxicas, uma vez que atuam como inibidores da enzima Acetilcolinesterase (AChE). O efeito mais preocupante da exposição a estes compostos é a toxicidade colinérgica aguda, ou seja, a perda de coordenação muscular. Uma vez que o indivíduo se contamina, o processo de intoxicação começa através da ligação do OP no sítio ativo da enzima AChE inativando-a. Os tratamentos atuais para pessoas expostas a baixas doses de OP podem ser realizados com atropina, oximas e benzodiazepínicos. Processos de remediação importantes envolvem o emprego de técnicas de biorremediação utilizando diferentes enzimas degradantes, como a Fosfotriesterase da Agrobacterium radiobacter e SMP-30. Devido ao elevado número de intoxicações anualmente, é crucial buscar métodos de tratamento mais potentes e eficazes, e nesta linha, as técnicas envolvendo biorremediação parecem ser bastante promissoras para este propósito.
Bioremediation potential of filamentous fungi in methylene blue: Solid and liquid culture media
Authors: Menezes Geovania dos Santos , Carvalho Tamíris Aparecida de , Almeida Wandson dos Santos , Sussuchi Eliana Midori , Viégas Pedro Roberto Almeida , Marino Regina Helena
Published: November 2017

ABSTRACT The evaluation of the bioremediation potential of microbial with dyes in solid and liquid culture media has been described, but prior studies have not mentioned which culture method is most appropriate for selection of microorganisms. Therefore, the aim of this work was to evaluate the bioremediation potential of filamentous fungi in liquid and solid culture media with methylene blue. The fungi isolates tested were Pleurotus ostreatoroseus (POR-SP1, POR-SP2), P. ostreatus (DF39, EF58 and EF60), Pycnoporus sanguineus (PS) and Fusidium sp. (FUS). The methylene blue concentrations tested were 0, 5, 10, and 50 mg L-1 in the solid medium and 0, 5, 25, 50, and 100 mg L-1 in the liquid medium. In the solid medium, the mycelial diameters of DF39, EF58, FUS, and PS were not influenced by the increase in dye concentration. In the liquid medium, DF39, EF58, EF60, and FUS showed a constant methylene blue degradation rate with increasing dye concentration. The dye degradation rate was correlated with the pH of the liquid medium for EF58, EF60, and FUS. The lower diameter growth in the solid medium did not influence the methylene blue dye degradation rate in the liquid medium.
Subluxação da mandíbula para abordagem de bifurcação carotídea alta em paciente com parotidite por contraste iodado: relato de caso e revisão de literatura
Authors: Santos Reinaldo Benevides dos , Queiroz André Brito , Fidelis Ronald José Ribeiro , Lopes Cicero Fidelis , Araújo Filho José Siqueira de
Published: November 2017

Resumo A doença aterosclerótica das carótidas extracranianas pode resultar em complicações com alta morbidade e mortalidade. A avaliação pré-operatória com exames contrastados de imagem é associada a complicações como a parotidite, além das já bem conhecidas reações alérgicas e da disfunção renal. A bifurcação carotídea alta e a doença aterosclerótica de extensão cranial costumam ser fatores limitantes para o tratamento cirúrgico convencional. Entretanto, quando há contraindicação ao uso de contraste iodado ou impossibilidade do tratamento endovascular, há a necessidade do conhecimento de técnicas cirúrgicas que permitam a realização da endarterectomia com segurança. A subluxação da mandíbula se mostrou uma técnica adjuvante segura e efetiva, de fácil execução e reprodutibilidade, possibilitando o acesso a bifurcações carotídeas altas com boa exposição do campo cirúrgico e permitindo a realização da endarterectomia conforme a técnica padrão. Apresentamos o caso de uma paciente com bifurcação carotídea alta e com limitações para uso do contraste iodado que foi submetida a endarterectomia carotídea após subluxação de mandíbula.
Growth regulator on oat yield indicators
Authors: Krysczun Dionatan K. , Silva José A. G. da , Marolli Anderson , Trautmann Ana P. B. , Lucio Alessandro D. , Carbonera Roberto
Published: November 2017

ABSTRACT Growth regulator in oat can reduce lodging with effects on yield indicators. The objective of the study is to define the optimum dose of growth regulator to reduce lodging in oats under different conditions of nitrogen (N) fertilization (reduced, high and very high) and the effects on yield indicators in the succession systems. In each succession system (soybean/oats and corn/oats), two experiments were conducted, one to quantify biomass yield and the other to estimate grain yield and lodging. In the four experiments, the design was randomized blocks with four replicates in 3 x 4 factorial scheme, for N-fertilizer doses (30, 90 and 150 kg ha-1) and growth regulator doses (0, 200, 400 and 600 mL ha-1), respectively. Growth regulator reduces lodging in oat plants, with the ideal doses of 500 mL ha-1 in the soybean/oat system and 400 mL ha-1 in the corn/oat system, regardless of the reduced, high and very high N doses. There is a linear reduction of biological and straw yields, and a quadratic trend in the expression of grain yield and harvest index as a function of the growth regulator doses, regardless of succession systems (soybean/oats and corn/oats).
ÍNDICE RELAÇÃO CINTURA-ESTATURA PARA PREDIÇÃO DO EXCESSO DE PESO EM CRIANÇAS
Authors: Vieira Sarah Aparecida , Ribeiro Andréia Queiroz , Hermsdorff Helen Hermana Miranda , Pereira Patrícia Feliciano , Priore Silvia Eloiza , Franceschini Sylvia do Carmo Castro
Published: November 2017

RESUMO Objetivo: Identificar um indicador de adiposidade abdominal de baixo custo e com maior acurácia para predizer o excesso de peso em crianças de quatro a sete anos idade. Métodos: Estudo transversal com amostra de 257 crianças de 4 a 7 anos. Os indicadores de adiposidade abdominal avaliados foram: perímetro da cintura (PC), relação cintura-estatura (RCE) e percentual de gordura central (avaliado pela técnica dual energy X-ray absorptiometry - DEXA). O excesso de peso foi classificado pelo índice de massa corporal por idade (IMC/I). Nas análises, estimou-se a razão de prevalência (RP) pela regressão de Poisson com variância robusta e utilizou-se a curva (receiver operating characteristics - ROC), considerando como significância estatística p<0,05. Resultados: A prevalência de excesso de peso foi de 24,9%, e observou-se maior mediana dos indicadores de adiposidade abdominal no grupo de crianças com excesso de peso. As crianças com valores aumentados de PC (RP=4,1; IC95% 2,86-5,86), RCE (RP=5,76; IC95% 4,14-8,02) e percentual de gordura central (RP=2,48; IC95% 1,65-3,73) apresentaram maior prevalência de excesso de peso. Verificou-se, na análise de curva ROC, que o índice RCE apresentou maior área sob a curva, comparado ao PC e ao percentual de gordura central estimada pelo DEXA, na predição do excesso de peso. Conclusões: Diante dos resultados, sugere-se a utilização da RCE para triagem de crianças com excesso de peso.
AS DAMAS DA ASSISTÊNCIA À INFÂNCIA E AS AÇÕES EDUCATIVAS, ASSISTENCIAIS E FILANTRÓPICAS (RIO DE JANEIRO/RJ, 1906-1930)
Authors: Camara Sônia
Published: November 2017

Resumo Este artigo visa refletir acerca do papel desempenhado pela Associação das Damas da Assistência à Infância que, criada em 1906, pelo Instituto de Proteção e Assistência à Infância do Rio de Janeiro, congregou mulheres da elite carioca na realização de iniciativas de assistência e de filantropia às crianças e às mães oriundas da pobreza. Para isso, elegemos, como foco de análise, os primeiros anos de funcionamento da Associação por consideramos que este período colabora para compreendermos o processo pelo qual se constituiu a conformação de um modelo de assistencialismo a ser realizado a partir, de então, pelas mulheres que compuseram a Associação, mas também de instituições congêneres criadas em vários estados do Brasil.
LAS BIBLIOTECAS ESCOLARES EN LA PRIMERA DÉCADA DEL FRANQUISMO: ENTRE EL AMANECER Y LA LUZ CEGADA
Authors: Malheiro Gutiérrez Xosé Manuel
Published: November 2017

Resumen Durante la guerra civil y primeros años de la dictadura del general Franco, el régimen surgido del golpe de estado se ocupó de barrer de la sociedad española toda huella republicana, especialmente en el campo pedagógico. Este texto reconstruye el proceso de expurgo de la biblioteca popular donada por el Patronato de Misiones Pedagógicas en el año 1935 a la escuela nacional de un pequeño pueblo de la provincia de Pontevedra. Se revisa la documentación del expediente que se conserva en el archivo de la escuela, compuesto por la correspondencia del maestro y los escritos oficiales, y se complementa con la necesaria revisión bibliográfica y de prensa periódica de la época. Ello nos permite documentar el proceso de depuración que se llevó a cabo en las bibliotecas públicas, como ejemplo del perpetrado en todo el Estado por parte de los golpistas; observar algunos rasgos de la orientación de la nueva política educativa y analizar el papel que se vieron obligados a desempeñar, a partir de ese momento, muchos maestros y maestras en un violento escenario de ruptura social, persecución política y sustitución ideológica.
INTEGRALISMO LUSITANO E EDUCAÇÃO CATÓLICA: CONEXÕES ENTRE INTELECTUAIS E O CASO DO COLÉGIO VASCO DA GAMA DE LISBOA, PORTUGAL (DÉCADA DE 1920)
Authors: Gonçalves Mauro Castilho
Published: November 2017

Resumo O artigo examina o projeto cultural e pedagógico do colégio lisboeta Vasco da Gama, instituição de ensino fundada em 1915, que pretendeu instruir e educar seus alunos sob as bases da educação física, da religião e das artes, à luz da doutrina católica, dos princípios integralistas e de uma rígida disciplina interna. Um periódico criado em meados dos anos de 1920, fonte central da investigação, serviu de esteio para configurar o projeto cultural do colégio e expressar de forma institucional uma rede de sujeitos conectados e ativos em tempos conturbados da política portuguesa. Fundamentado na história dos intelectuais e do político, o estudo, por fim, analisa conexões entre o integralismo lusitano e o nacionalismo católico brasileiro.
O ECLETISMO EDUCACIONAL GERMÂNICO, PRECURSOR DA EDUCAÇÃO COMPARADA? RECEPÇÕES E LEGADO DE GRUNDSÄTZE DE HERMANN AUGUST NIEMEYER NO ESPAÇO FRANCO-SUÍÇO
Authors: Fontaine Alexandre
Published: November 2017

Resumo Hermann August Niemeyer (1754-1828) é certamente um dos pedagogos que mais dominou a educação do século XIX, embora sua obra seja pouco conhecida, quase totalmente esquecida. Autor de uma centena de obras e de folhetos, suas produções circularam em toda a Europa e contribuíram no modo de apreender e de pensar a pedagogia. Expôs seu pensamento em um “compêndio pedagógico geral”, publicado em Halle em 1796, intitulado Grundsätze der Erziehungund des Unterrichts für Eltern, Hauslehrer und Erzieher, bestseller pedagógico europeu cujo peso e normas ainda se fazem presentes em centenas de nossas instituições. Este artigo procurará esclarecer a recepção da obra norteadora de Niemeyer no espaço franco-suíço. Desvendaremos também, a partir dos Grundsätze e do ecletismo germânico, do qual Niemeyer é o principal representante, a existência de uma tradição comparatista anterior aos trabalhos de Marc-Antoine Jullien, designado “pai da educação comparada” por Pedro Rossello, seguindo a tradição do Bureau international d’éducation fundado em Genebra em 1925.
Trends and patterns of Antibiotic Consumption in China’s Tertiary Hospitals: based on a 5 year surveillance with sales records, 2011-2015 v1
Authors: Wushouer Haishaerjiang , Tian Ye , Guan Xiao-Dong , Han Sheng , Shi Lu-Wen
Published: November 2017

The consumption of antibiotics is a major driver for the development of antibiotic resistance in bacteria. We identified the trends and patterns of total antibiotic consumption in China’s tertiary hospitals from 2011 to 2015. We retrospectively analyzed aggregated monthly surveillance data on antibiotic sales made to 468 hospitals from 28 provinces. Antibiotic consumption was expressed in DDD per 1000 inhabitants per day (DID). We compared population weighted antibiotic consumption patterns in China with European countries using indicators from the European Surveillance of Antimicrobial Consumption (ESAC). Total antibiotic consumption in general, including all the specific antibiotic class except for aminoglycoside antibacterials, were significantly increased during the study period from an average of 7.97 DID in 2011 to 10.08 DID in 2015. In 2015, eastern regions consumed the most antibiotics if using population based calculation while west regions consumed the most using inpatient volume based calculation. Cephalosporins accounted for 28.6% of total DID, followed by beta-lactam-beta-lactamase inhibitor combinations with 20.0%, macrolides with 17.4%, and fluoroquinolones with 10.5%. Antibiotic in parenteral form were accounted for nearly half of all antibiotics. We used aggregated sales records data to monitor antibiotic consumption across China over a 6 year period. Although great efforts had been made through antibiotic stewardship in the past few years, total antibiotic consumption showed a significant upward trend during the study period. A consistent preferences for cephalosporins, macrolides, beta-lactam-beta-lactamase inhibitor combinations, as well as parenteral preparations was observed. More efforts are needed in the future to investigate the quality of antibiotic prescribing.
Simple His-Tag Column Prep Procedure v2
Authors: Paul Gold Dr.
Published: November 2017

GoldBio's simple His-Tag column prep protocol is a quick and easy method to pouring and packing an agarose resin column.
Addressing new challenges for a community music project in the context of higher music education: A conceptual framework
Authors: Gande Andrea , Kruse-Weber Silke
Published: November 2017

In response to Europe's societal challenges, such as current issues about migration, the Institute of Music Education at the University of Music and Performing Arts Graz established Meet4Music (M4M), a low-threshold community music project. M4M is open to individuals from all sociocultural
and musical backgrounds and ages, and provides them with the opportunity to socialize with others and to express themselves musically. M4M is based on collaborative learning in an open community ensemble, which includes choir, dance, theatre and percussion, alternating with one another on
a weekly basis. University students can choose M4M as an elective course to gain relevant experience in leading heterogeneous and intercultural ensembles. The aim of this paper is to present this project, with a special focus on its dimensions, aims and pedagogical implications for educating
reflective teachers. A conceptual framework that contributes to the concept of lifelong learning in (higher) music education will be provided, and foundations for further research and theory will be offered.
Teaching music online: Changing pedagogical approach when moving to the online environment
Authors: Johnson Carol
Published: November 2017

The development of educational technology has provided platforms for undergraduate music courses to take place in an online environment. While technology is available, this does not mean that all teaching staff are ready for the pedagogical change required to implement teaching online.
A transformation of pedagogical practice (that is, to online pedagogy) is required for teaching courses online. Researchers suggest that the use of social-constructivist learning and collaborative online learning models strongly support online student learning. The following case study explores
how teaching staff in an American university music department (N=7) transformed their pedagogy when teaching undergraduate music courses online. The study highlights the diversity of perceptions about teaching music online, and the influence of these perceptions on the pedagogical approaches
and strategies used when teaching and developing an online music course. The pedagogical elements of teaching music online were found to have connections with the community of inquiry framework's nexus of teaching presence, cognitive presence and social presence, and suggested a social-constructivist
course design. Finally, the findings show that teaching staff experienced a shift of pedagogical approach when transitioning to teaching music online. Implications include assisting music faculty in the adoption of pedagogical approaches and that they should be addressed at individual, departmental
and institutional levels.
Construct Validity and Reliability of the Beliefs Toward Mental Illness Scale for American, Japanese, and Korean Women
Authors: Arnault Denise M. Saint , Gang Moonhee , Woo Seoyoon
Published: November 2017

Purpose: The aim of this study was to evaluate the psychometric properties of the Beliefs Toward Mental Illness Scale (BMI) across women from the United States, Japan, and South Korea. Methods: A cross-sectional study design was employed. The sample was 564 women aged 21–64 years old who were recruited in the United States and Korea (American = 127, Japanese immigrants in the United States = 204, and Korean = 233). We carried out item analysis, construct validity by confirmatory factor analysis (CFA), and internal consistency using SPSS Version 22 and AMOS Version 22. Results: An acceptable model fit for a 20-item BMI (Beliefs Toward Mental Illness Scale–Revised [BMI-R]) with 3 factors was confirmed using CFA. Construct validity of the BMI-R showed to be all acceptable; convergent validity (average variance extracted [AVE] ≥0.5, construct reliability [CR] ≥0.7) and discriminant validity (r = .65–.89, AVE >.79). The Cronbach’s alpha of the BMI-R was .92. Conclusion: These results showed that the BMI was a reliable tool to study beliefs about mental illness across cultures. Our findings also suggested that continued efforts to reduce stigma in culturally specific contexts within and between countries are necessary to promote help-seeking for those suffering from psychological distress.
Las series de tiempo fractales y un método de pronóstico
Authors: Romero-Meléndez Guillermo , Ojeda-Suárez Rogelio , Nava-Huerta Agustín , García-Valdez Carlos Alberto
Published: November 2017

Los autores presentan aquí un método de pronóstico para las series de tiempo fractales, y una variación de la fórmula de Feder que estimula el movimiento browniano fraccionario. Aplicamos este método a las cifras del índice de precios y cotizaciones (IPC) de la Bolsa Mexicana de Valores desde el 22 de noviembre de 2002 hasta el 16 de febrero de 2004. Por último, comparamos los resultados con otros dos métodos, incluyendo un método de pronóstico econométrico AR(1).
Administración de los problemas financieros en los bancos. Dilema entre los riesgos de liquidez y solvencia
Authors: Bougheas Spiros , Ruiz Porras Antonio
Published: November 2017

Elaboramos un marco microeconómico de la banca para analizar cómo influyen las decisiones de administración de la liquidez en la disponibilidad de liquidez para los depositantes, la viabilidad del proceso de transformación de activos y la solvencia de las empresas bancarias. En particular, nos centramos en la manera como la asignación óptima de los depósitos entre las reservas y una cartera de inversión riesgosa, hecha por un banco que maximiza sus ganancias, afecta la probabilidad de cada tipo de quiebra bancaria en un ambiente en el que hay incertidumbre en ambas pautas de los saldos. Nuestra meta principal es examinar los dilemas de riesgo-administración entre los riegos provenientes de la incertidumbre en el comportamiento de los depósitos y los provenientes de los activos de su saldo asociados al riesgo inherente a su cartera de inversión. Distinguiendo entre la iliquidez y la insolvencia como causas de las quiebras bancarias, intentamos entender cómo afecta la interacción entre estos dos tipos de riesgo al proceso de transformación de activos del banco.
Estrategia de exportación desde Argentina hacia México de cuadernos de espiral
Authors: Páez Héctor Ricardo , Quintas Luis Guillermo
Published: November 2017

En este trabajo se analiza la factibilidad de exportación en contratemporada de Argentina a México de cuadernos de espiral, por parte de una empresa radicada en Argentina. Se analiza el mercado argentino y mexicano y se estudia el posicionamiento estratégico de las empresas que operan en el mercado mexicano. Se incluye un análisis de sensibilidad en función del tipo de cambio y se consideran varios otros panoramas. Se concluye que la opción propuesta es altamente conveniente, tanto en la faz técnica como la temporal, lo que permitiría un mejor posicionamiento de la empresa exportadora.
On Image Formulae Leading to Fractional Kinetic Equations Solutions via Sumudu Generalized k-Bessel Functions
Authors: Nisar Kottakkaran S. , Abouzaid Moheb S. , Belgacem Fethi Bin M.
Published: November 2017

Recently, representation formulae and monotonicity properties of generalized k-Bessel functions, Wk v,c., were established and studied by SR Mondal [24]. In this paper, we pursue and investigate some of their image formulae. We then extract solutions for fractional kinetic equations, involving Wk v,c, by means of their Sumudu transforms. In the process, Important special cases are then revealed, and analyzed.
Cryoablation of Bone Metastases from Renal Cell Carcinoma for Local Tumor Control
Authors: Gardner Carly S. , Ensor Joe E. , Ahrar Kamran , Huang Steven Y. , Sabir Sharjeel H. , Tannir Nizar M. , Lewis Valerae O. , Tam Alda L.
Published: November 2017

Background:

Patients with bone metastases from renal cell carcinoma often are not surgical candidates and have a poor prognosis. There are limited data on the use of cryoablation as a locoregional therapy for bone metastases. Our objective was to assess the local tumor-control rate following cryoablation of bone metastases in the setting of renal cell carcinoma.

Methods:

We retrospectively reviewed the medical records of patients with metastatic renal cell carcinoma who underwent cryoablation for bone metastases between 2007 and 2014. We excluded patients if the intent of treatment was for pain palliation only, if cryoablation was performed without an attempt for complete tumor control (cytoreduction), or if the patient had no further follow-up beyond the cryoablation procedure. We recorded patient demographics, procedural variables, and complications. Cross-sectional imaging and clinical follow-up were reviewed to determine disease recurrence. The median overall survival and recurrence-free survival were determined using the Kaplan-Meier method.

Results:

Forty patients (30 male and 10 female) with 50 bone metastases were included for analysis. The mean patient age was 62 years (range, 47 to 82 years). The median follow-up was 35 months (95% confidence interval [CI], 22.7 to 74.4 months). Twenty-five (62.5%) of the 40 patients had oligometastatic disease, defined as ≤5 metastases at the time of ablation. The mean tumor size was 3.4 ± 1.5 cm. Metastases in the pelvic region represented 68% of the treated tumors (34 of 50). The overall local tumor-control rate per lesion was 82% (41 of 50). Patients with oligometastatic disease experienced better local tumor control (96% [24 of 25]) compared with patients who had >5 metastases (53.3% [8 of 15]) (p = 0.001). The local tumor-control rate was better for lesions for which a larger mean difference between maximum ice-ball diameter and maximum lesion diameter was achieved (2.2 ± 0.9 cm for those without recurrence versus 1.35 ± 1.2 cm for those with recurrence; p = 0.005). There were 3 grade-3 complications and 1 grade-4 complication.

Conclusions:

Cryoablation can be effective for achieving local oncologic control in bone metastases from renal cell carcinoma and may represent a valuable alternative to surgical metastasectomy in select patients.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Nationwide Analysis of Femoral Neck Fractures in Elderly Patients
Authors: Ju Derek G. , Rajaee Sean S. , Mirocha James , Lin Carol A. , Moon Charles N.
Published: November 2017

Background:

Geriatric femoral neck fractures are associated with substantial morbidity and medical cost. We evaluated the incidence and management trends of femoral neck fractures in recent years in the U.S.

Methods:

Patient data from 2003 through 2013 were obtained from the Nationwide Inpatient Sample database. Femoral neck fractures in patients ≥65 years old were identified and grouped using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) procedure codes for internal fixation, hemiarthroplasty, or total hip arthroplasty (THA). The nationwide incidence of femoral neck fractures was calculated and presented as an age-adjusted population rate. Univariable methods were used for trend analysis and comparisons between groups. Logistic regression modeling was used to analyze complications.

Results:

From 2003 to 2013, we identified 808,940 femoral neck fractures in patients ≥65 years old. The national age-adjusted incidence of femoral neck fractures decreased from 242 per 100,000 U.S. adults in 2003 to 146 in 2013. The proportion of fractures managed operatively with THA increased over time (5.9% in 2003 versus 7.4% in 2013; p < 0.001). Concurrently, the use of hemiarthroplasty declined (65.1% versus 63.6%; p < 0.001). In 2013, the median age of the patients treated with THA was significantly younger (77.3 years) compared with that in the hemiarthroplasty and internal fixation groups (83.2 and 82.0 years). The THA group had significantly higher median initial hospital costs ($17,097) compared with the hemiarthroplasty and internal fixation groups ($14,776 and $10,462).

Conclusions:

In the last decade, the total number and population rate of femoral neck fractures in the elderly declined significantly. There was a modest but significant increase in the utilization of THA.

Clinical Relevance:

This report identifies the changing trends in clinical practice in the treatment of geriatric femoral neck fractures in the U.S. Treating physicians should be aware of these trends, which include a decreasing national incidence of geriatric femoral neck fractures as well as an increase in the use of THA.
The Pursuit of Scholarship: Why We Should Care About Resident Research
Authors: Bechtold Joan E. , Williams Benjamin R. , Weinstein Stuart L. , Polly David W. , Pugely Andrew J. , Buckwalter Joseph A. , Albanese Stephen A. , Bozic Kevin J. , Snyder Brian D.
Published: November 2017

Research is a foundational component of an orthopaedic residency. It fosters intellectual curiosity and pursuit of excellence, while teaching discipline and the scientific method. These are the key principles for careers in both community-based practice and academia. Currently, no consensus exists on how to best engage residents and support their research endeavors. In 2014, the American Academy of Orthopaedic Surgeons Board of Specialty Societies Research and Quality Committee convened a Clinician-Scientist Collaboration Workgroup. The workgroup’s task was to identify barriers to clinical and basic science research, and to propose feasible recommendations to overcome these barriers. Herein, we have compiled the opinions of various stakeholder constituencies on how to foster scholarly pursuits during an orthopaedic residency. These opinions reflect the workgroup’s conclusions that research is directly and indirectly influenced by funding, departmental support, and mentorship, and that early exposure and dedicated time to pursue scholarly activities may have a positive impact on lifelong research interests.
Support for Safer Opioid Prescribing Practices
Authors: Lovecchio Francis , Derman Peter , Stepan Jeffrey , Iyer Sravisht , Christ Alexander , Grimaldi Peter , Kumar Kanupriya , Ranawat Anil , Taylor Samuel A.
Published: November 2017

➤ The opioid epidemic places enormous social, ethical, and legal pressure on orthopaedic prescribers to balance postoperative pain relief with responsible prescribing practices.

➤ A catalog of the type and average number of narcotic pills used by patients recovering from various orthopaedic surgeries may serve as a starting point for safe opioid prescribing strategies.

➤ Prescriber education and guidelines that depersonalize discussions about the maximum strength and number of pills that can be provided may reduce overprescribing.

➤ The large ranges of opioid consumption reported in many studies challenge the notion that opioid use is an objective measure of pain level and prompt further investigation into the variety of individual or cultural factors that may influence postoperative opioid consumption.
Novel Strategies to Improve Resident Selection by Improving Cultural Fit
Authors: Porter Scott E. , Razi Afshin E. , Ramsey T. Bennett
Published: November 2017

Residency selection is a perennial multifactorial process that differs considerably from the recruitment processes that other professional occupations enjoy. The 2016 meeting of the American Orthopaedic Association’s Council of Orthopaedic Residency Directors highlighted a series of symposia that sought to present a novel manner of resident selection. Specifically, the presenters for each symposium were asked to do the following: present some general recruitment best practices in industries outside of medicine, present how branding of a program may translate into a better interview season, investigate evidence that the applicant pool to orthopaedic surgery may have changed and that residency program brands may have to reflect this, and assess our current evaluation techniques for talent identification and resident selection with respect to a specific department’s appearance or brand. The meeting concluded with an understanding of the level to which programs can successfully create or adopt a brand and how this may go a long way in focusing the entire match process and allow emphasis to be placed on applicants who possess desired traits. The goal for this meeting was that attendees would leave with tangible practices and techniques that could be adopted at their home institutions.
Adaptasi Beberapa Varietas Jagung pada Agroekosistem Lahan Kering di Maluku
Authors: Kaihatu Sheny Sandra , Pesireron Marietje
Published: November 2017

Maize has an important role in the national economy, but at some area, including in Maluku, the productivity is still low, below its potential productivity. The productivity of maize could be improved by planting high yielding and adaptive variety to the local environment. Study was conducted in the Haruru village, District Amahai, Central Maluku, from March to August 2012 aimed to identify maize varieties adaptive on dry land agro ecosystem. The study used randomized block design, replicated three times, where farmers’ fields were used as replications. The varieties tested were Srikandi Kuning, Gumarang, and Sukmaraga composites varieties. Bima-2 and Bima-2 (hybrid varieties) and Mutiara, Ungu Hati Putih, Merah, Orange Hati Putih, and Orange Hati Merah (local variety, obtained from farmers’ fields in the district of MTB). Fertilizers were drilled, 5-7 cm on the side of plant at a rate of 135 kg N, 90 kg P2O5, 60 kg K2O and 1-2 t manure/ha. Variables to be measured were percentage of surviving plants, age at 50% of male flowering, age at 50% of female flowering, plant height, ear height, cob length, cob weight, cob diameter, number of rows/ear, seed number per ear row, 100-seed weight, weight of dry grains, moisture content, and grain yield. Results showed that local varieties indicated a better growth, but grain yield were superior for the hybrid and the composite varieties. Bima-4 hybrid variety produced 10.31 t/ha dry grain, followed by Bima-2 hybrid and the composite varieties of Sukmaraga, Srikandi Kuning, and Gumarang, each was 8.70 t/ha, 7.97 t/ha, 7.60 t/ha and 7.26 t/ha, respectively. Local varieties Mutiara, Orange Hati Putih, Merah, Orange Hati Merah, and Ungu Hati Putih each yielded only 3.74 t/ha, 3.32 t/ha, 3.07 t/ha, 3.02 t/ha and 2.45 t/ha respectively.
Preferensi Konsumen terhadap Beras Berlabel Jaminan Varietas (BBJV) untuk Hipa 8, Ciherang dan Inpari 13
Authors: Indrasari Siti Dewi , Purwaningsih Purwaningsih , Apriyati Erni , Ardhiyanti Shinta Dewi
Published: November 2017

The objectives of this research was to study the consumer acceptance to variety assurance rice labelled  (VARL) wihich is produced by  “Kopkarlittan” of Indonesian Center for Rice Research (ICRR). The research was conducted on September to November 2013. The respondents were asked to answer the question in questionaire and assessing the rice and cooked rice presented. The preference assessment was carried out to every rice atributes  such as aroma, color, shape, wholeness, cleaness and general acceptance (like or dislike). The same assessment was also carried out to the cooked rice with different atributes such as aroma, color, translucency, softness, taste and general acceptance. The rice used were Hipa 8 variety which is represent aromatic rice and Ciherang and Inpari 23 represent non aromatic rice. Those rice were produced by “Kopkarlittan” ICRR. As controlled were used non variety assurance labelled rice (NVARL) which were bought from two modern market LM and C in Jakarta. The organoleptic data were analysed by Kruskal-Wallis test and presented in decriptive way. In general the respondents  stated that VARL products is better than other NVARL product in term of shape, wholeness, cleaness, taste of cooked rice, nutritional and functional quality. Other respondents stated that VARL products is the same with NVARL products in term of color. In general the consumers in Jakarta, Bandung and Yogyakarta stated  that  there is no preference different based on color, aroma, shape, wholeness and cleaness of aromatic rice sold in LM and C modern market, except general accetance atribute of Hipa 8 variety. The consumers also stated that there is no preference different to Hipa 8 cooked rice based on aroma, color, translucency, softness, taste and general acceptance. But there is preference different of aromatics cooked rice sold in LM  modern market based on color, translucency, softness and taste atributes. In general consumers in Jakarta, Bandung and Yogyakarta stated that  there is no preference different of  non aromatic rice and cooked rice sold in LM, C modern market dan Inpari 13 variety.
Responses of Selected Indonesian Rice Varieties under Excess Iron Condition in Media Culture at Seedling Stage
Authors: Nugraha Yudhistira , Ardie Sintho Wahyuning , Ardie Sintho Wahyuning , Rumanti Indrastuti A. , Rumanti Indrastuti A. , Suwarno Suwarno , Suwarno Suwarno , Ghulammahdi Munif , Ghulammahdi Munif , Aswidinnoor Hajrial , Aswidinnoor Hajrial
Published: November 2017

Iron toxicity could limit rice productivity on irrigated lowland acid and swampy soil. The use of iron toxicity tolerant rice is an alternative strategy to improve rice productivity in these areas. We studied the phenotypic variation of twenty-four rice genotypes and characterized the fate of Fe2+ along its path between the roots and shoot of rice plant. Twenty-four rice genotypes form different agro-ecosystem were grown under agar nutrient solution conditions with 400 mg. L-1 iron stress and under normal condition. We found variation in the biomass accumulation of rice seedling during stress of iron namely, high accumulated biomass tolerant type and low accumulate biomass tolerant type. The relative biomass weight was highly correlated with the leaf bronzing scores (LBS) under excess iron. Based on these categorizations, we chose six genotypes to observe the present of Fe in root and shoot using invivo-staining 2,2 bypiridine. The result indicated that some genotypes were able to develop root and shoot aerenchym during iron stress. This was related to the development on root iron plaque and the iron content of the shoot of the rice seedling. In this present study, rice genotypes could be classified as the includer tolerant type (Inpara 2) and some others were the excluder tolerant type (Mahsuri, Pokkali and Siam Saba). This information on tolerance strategies is important for rice breeder to develop physiological-based breeding program of iron-toxicity tolerant in rice.
Seleksi Fenotipe Populasi Padi Gogo untuk Hasil Tinggi, Toleran Alumunium dan Tahan Blas di Tanah Masam
Authors: Mulyaningsih Enung Sri , Perdani Ambar Yuswi , Indrayani Sri , Suwarno Suwarno
Published: November 2017

The aims of research is to get upland rice lines with high yield, aluminum tolerance and resistance of blast. Genetic material were used 380 lines (F6) from six hybridization combination were evaluated under stress Al condition in environment endemic blast by using augmented design with five randomized block. Performance of lines at the field and level of tolerance was tested.  The results showed that have five genetic clusters formed of 380 lines of upland rice in a test based on a quantitative character. The best cluster is cluster number 3 with lines that have characters growth vigor of plants are uniform, 50% flowering  days short, harvesting of early maturing, high plant medium, amount of productive tillers is high, medium on panicle length, the most number of filled grain, the lowest of empty grains, the most weight of 5 panicles and high yield potential. Aluminum Tolerant and Blast Resistant owned by almost  all clusters. But the lines on the cluster 3 have highest resistance to blast and Al at 96%.
BREAST CANCER IN MEN IN THE REPUBLIC OF BASHKORTOSTAN
Authors: Sakaeva D. D. , Atnabaev R. D. , Ruchkin V. V.
Published: November 2017

Breast cancer in men is 100 times less common than in women. The principles of treatment of breast cancer in men are still based on knowledge obtained during the treatment of women with a similar pathology. The article reviews 67 cases of all breast cancer stages  in men. The majority (50.7%) of all patients who initiated therapy had stage  III-IV tumors. In most cases,  the  patients  had  an  infiltrating ductal  carcinoma (52.2%). The combination  and  complex  treatment  methods accounted for 53.6% of all cases. The radical mastectomy (89.6%) was the most frequent method of operative intervention. 29 patients (43.3%) received preoperative chemotherapy. 36 patients received adjuvant treatment. The adjuvant treatment comprised chemotherapy (29 patients), and subsequently was supplemented with antihormonal therapy in patients with receptor-positive tumors. The anthracycline-containing chemotherapy was the most prevalent among treatment regimens (72.4%). In 7 patients with a locally diffused process, the treatment was supplemented with radiotherapy. 72.2% of patients had a clinically significant estrogen receptor (RE) expression in the tumor and 61% of patients had a progesterone receptor (RP) expression. 85.0% of patients with stages  I-IIA breast cancers showed the relatively high 5-year survival rates, and 67.5% of patients with stage IIB cancers showed 5-year survival. The survival rates for stages III and IV cancer were 18.1% and 16.6%, respectively.
DARATUMUMAB FOR THE TREATMENT OF MULTIPLE MYELOMA
Authors: Ryzhko V. V. , Kanaeva M. L.
Published: November 2017

The use of proteasome inhibitors and immunomodulatory drugs in the clinical practice has contributed to the significant improvement in survival for patients with multiple myeloma over the past decades. Alongside this, due to the recurrent course of the disease, there is a need to introduce new classes of drugs to clinical practice. In 2015,  the FDA (USA) approved two monoclonal  antibodies  for use  in  patients  with  relapsed  multiple  myeloma,  and  immunotherapy has  rapidly become indispensable  in the management of such patients. The article presents an analysis of the published data regarding the mechanism of action, safety and clinical efficacy of daratumumab, a human monoclonal antibody that targets CD38 tumor protein, for the  treatment  of patients  with multiple  myeloma. In Russia, daratumumab is registered  (RU LP-004367  of 07.07.2017) and is indicated as monotherapy for patients with relapsed or refractory multiple myeloma, who have received prior therapies, incuding proteasome  inhibitors and immunomodulatory drugs. Daratumumab demonstrated  an excellent safety profile. In the context of daratumumab therapy, the moderate-grade infusion-related reactions occurring mostly during the  first infusion  are the  main adverse  events.  Daratumumab-based combination  therapies  are currently under active evaluation in patients with relapsed and newly diagnosed myeloma.
Basic characteristic parameters and influencing factors of long-period ground motion records
Authors: Cheng Yu , Bai Guo Liang
Published: November 2017

199 earthquake records with reliable information are selected from the PEER and NIED firstly, and the Seismo Signal software is applied to correct the baseline of original earthquake records. Then the basic characteristics and strength parameters under near-fault/far-field long-period ground motions and common ground motions are compared. Moreover, the influence on basic strength parameters affected by earthquake magnitude, rupture distance (or epicenter distance) and site condition under near-fault/far-field long-period ground motions is analyzed one by one. Study results are obtained as follows: Near-fault earthquake has high amplitude intensity and short strong-shock duration, and its energy release process is concentrated in a short time. A Far-field earthquake has a small peak of acceleration, velocity, displacement and long strong-shock duration, and its energy release process is mild. The strength parameter index PGV/PGA under long-period ground motions is beyond 0.2, and its frequency distribution is concentrated within the low-frequency band (0.1-1.0 Hz) while the frequency distribution of common ground motions is concentrated within a relatively high-frequency band (1.0-2.3 Hz); The strength parameter indexes IA, Eρ, P, IC and CAV under near-fault earthquake are greater than those under far-field earthquake. For a near-fault earthquake, the parameter index PGA decreases, and the strong-shock duration increases with the earthquake magnitude from Mw 6.6 to Mw 7.3, while the parameter index PGA, PGV decreases and PGV/PGA, strong-shock duration increase with the increases of rupture distance. Site-soil condition is the key factor affecting the basic strength parameter index under far-field earthquake, and the PGA, PGV parameter indexes increase under far-field earthquake with the site soil condition from class C to D and E. It is suggested to be related to the effect of filtering out high-frequency components and amplifying low-frequency components in soft site-soil.
Application of the polynomial dimensional decomposition method in a class of random dynamical systems
Authors: Lu Kuan , Hou Lei , Chen Yushu
Published: November 2017

The polynomial dimensional decomposition (PDD) method is applied to study the amplitude-frequency response behaviors of dynamical system model in this paper. The first two order moments of the steady-state response of a dynamical random system are determined via PDD and Monte Carlo simulation (MCS) method that provides the reference solution. The amplitude-frequency behaviors of the approximately exact solution obtained by MCS method can be retained by PDD method except the interval close to the resonant frequency, where the perturbations may occur. First, the results are shown on the two degrees of freedom (DOFs) spring system with uncertainties; the dynamic behaviors of the uncertainties for mass, damping, stiffness and hybrid cases are respectively studied. The effects of PDD order to amplitude-frequency behaviors are also discussed. Second, a simple rotor system model with four random variables is studied to further verify the accuracy of the PDD method. The results obtained in this paper show that the PDD method is accurate and efficient in the dynamical model, providing the theoretical guidance to complexly nonlinear rotor dynamics models.
The dynamics of eccentric vibration mechanism (Part 1)
Authors: Leonid Igumnov A. , Vladimir Metrikin S. , Irina Nikiforova V.
Published: November 2017

This paper presents a mathematical model of a new multi-striker eccentric shock-vibration mechanism (ESVM) with a crank-sliding bar vibration exciter (CSVE) and an arbitrary number of pistons. Analytical solutions for the parameters of the model are obtained to determine the regions of existence of stable periodic motions. Under the assumption of an absolutely inelastic collision of the piston, we derive equations that single out a bifurcational unattainable boundary in the parameter space, which has a countable number of arbitrarily complex stable periodic motions in its neighborhood. We present results of numerical simulations, which illustrate the existence of periodic and stochastic motions. The methods proposed in this paper for investigating the dynamical characteristics of the new crank-type conrod mechanisms allow practitioners to indicate regions in the parameter space, which allow tuning these mechanisms into the most efficient periodic mode of operation, and to effectively analyze the main changes in their operational regimes when the system parameters are changed.
Modal analysis of the vertical moving table of 4-DOF parallel machine tool by FEM and experimental test
Authors: Mahboubkhah Mehran , Pakzad Sajjad , Ghane Arasi Ali , Ettefagh Mir Mohammad
Published: November 2017

The vibration of the machine tool has important effect on machining quality of parts. So, in this paper, the dynamic behavior and modal parameters of the vertical moving table of the 4-DOF parallel machine tool are studied using the FEM and experimental methods. The prepared model of the vertical moving table in Solidworks is exported to ANSYS environment. Then, its natural frequencies and mode shapes are extracted using the modal analysis. Then having the FEM results, the exact modal data of the vertical moving table is obtained by the experimental tests. The exciting conditions of the machine tool table are obtained through modeling of machining operations. Finally, the resonance situations of the table are found using the modal data of the table and the cutting parameters of the machine tool. The results of this research can help the machine tool operator to avoid the vibration condition through correct selection of the cutting parameters.