bluuebunny/crossref_metadata_2025 huggingface dataset:
ИСПОЛЬЗОВАНИЕ B-БЛОКАТОРОВ ДЛЯ МЕСТНОГО ЛЕЧЕНИЯ ГЕМАНГИОМ
Authors: Vitovska O. , Barinov Iu. , Voitko L.
Published: January 2022

Гемангиома – одна из наиболее распространенных опухолей первого года жизни. В 2010 году в Украине приобрело распространение лечения геманги ом при помощи β-блокаторов. В данной статье рассматривается возможность лечения гемангиом при помощи местных аппликаций смеси тимолола и димексида. В исследование включено 30 пациентов, разделенных на 4 группы в зависимости от типа и локализации гемангиомы. У всех пациентов наблюдалось прекращение активного роста новообразования.
ЭФФЕКТИВНОСТЬ НОВОГО СПОСОБА РЕВИЗИИ ФИЛЬТРАЦИОННОЙ ПОДУШКИ ПОСЛЕ ИМПЛАНТАЦИИ УСТРОЙСТВА Eх-PRESS ДЛЯ ФИЛЬТРАЦИИ ЖИДКОСТИ ПРИ ГЛАУКОМЕ
Authors: Bezdetko P. , Medvedchuk S.
Published: January 2022

Целью работы была разработка способа ревизии фильтрационной подушки с восстановлением проходимости устройства Ех-PRESS для фильтрации глазной жидкости и оценка эффективности данной методики оперативного вмешательства.В статье приведены результаты ревизии фильтрационной подушки у 60 пациентов, которые были разделены на 2 группы по 30 человек в каждой в зависимости от модели имплантированного устройства Ех-PRESS (Р-50 или Р-200).Выполнение оперативного вмешательства с восстановлением проходимости устройства Ех-PRESS для фильтрации глазной жидкости по предложенной нами методике среди пациентов І группы привело к нормализации ВГД в 83,3 % случаев (5 глаз) на протяжении 21 мес., в 16,7 % случаев (1 глаз) в этой группе вмешательство выполнено повторно через 6 мес. после первой ревизии.У пациентов II группы выполнение ревизии фильтрационной подушки нормализовало ВГД в 100% случаев на протяжении 21 мес. после проведения.
РОЛЬ СИНДРОМА «СУХОГО» ГЛАЗА ПРИ ПАТОЛОГИЧЕСКИХ СОСТОЯНИЯХ ОРГАНА ЗРЕНИЯ
Authors: Rykov S. O. , Shargorodska I. V. , Gurska D. D. , Liemiemieva A. A. , Yakovets A. I.
Published: January 2022

Представлен анализ изучения роли синдрома «сухого» глаза при патологических состояниях органа зрения. Для анализа были исследованы 30 пациентов (60 глаз) с синдромом «сухого» глаза различной степени тяжести. В зависимости от сопутствующей офтальмологической патологии все пациенты были разделены на 3 группы. Помимо комплексного офтальмологического обследования в динамике, анализа изменений субъективных ощущений, показателей слезопродукции, стабильности слезной пленки проводили цитологическое исследование бульбарной конъюнктивы. В зависимости от тяжести ССГ всем пациентам была рекомендована патогенетически обоснованная слезозаместительная терапия.Исследования подтвердили факт главенствующих позиций нарушения липидного слоя слезной пленки в патогенезе синдрома «сухого» глаза. В результате проведенного исследования выявлена корреляция степени проявления признаков воспаления поверхности глаза, показателей слезопродукции, стабильности слезной пленки, клинических проявлений и субъективных жалоб. Результаты имрессионной цитологии подтвердили факт нарушения местного клеточного иммунитета у пациентов с ССГ. При цитологическом исследовании отпечатков конъюнктивы у пациентов I, II и III групп отмечались изменения гистоцитарных элементов, свидетельствующие в пользу воспалительного процесса, особенно эти изменения проявлялись у пациентов II группы, которые, кроме ССГ, имели первичную открытоугольную глаукому.В результате базисной слезозаместительной терапии, которая содержала препарат на основе натрия гиалуроната, был отмечен положительный эффект назначенного лечения.Обоснована необходимость проведения дальнейших исследований с целью выявления долевого участия факторов воспаления глазной поверхности в патогенезе развития синдрома «сухого» глаза и других патологических состояний.
ВОСПАЛИТЕЛЬНЫЕ ЗАБОЛЕВАНИЯ ПОВЕРХНОСТИ ГЛАЗА: СОВРЕМЕННЫЕ ВОЗМОЖНОСТИ ДИАГНОСТИКИ И ЛЕЧЕНИЯ
Authors: Rykov S. A. , Shargorodska I. V. , Gurska D. D. , Liemiemieva A.A. , Nikolayshuk N. S. , Vaduk L. I. , Belyaeva О. А.
Published: January 2022

Представлен анализ изучения современных возможностей диагностики и лечения воспалительных заболеваний поверхности глаза (ВЗПГ). Обследовано 80 глаз (40 пациентов) с синдромом «сухого глаза» (ССГ) и аллергическими конъюнктивитами. В зависимости от схемы патогенетически обоснованной слезозаместительной терапии пациенты были разделены на 3 группы. Всем пациентам проводилось комплексное офтальмологическое обследование в динамике, а также анализ осмолярности слезной жидкости, анкетирование с оценкой жалоб по 4-х балльной шкале и диагностические пробы: тест Ширмера, проба Норна, флюресцеиновый и LIPKOF тесты. Состояние эпителия роговицы и конъюнктивы оценивали методом импрессионной цитологии (по стандартной методике) с использованием миллипоровых фильтров. Для изучения гуморальных звеньев местного иммунитета исследовали содержание иммуноглобулинов в слезе иммуноферментным методом.Результаты исследования подтверждают факт главенствующих позиций нарушения липидного слоя слезной пленки в патогенезе ССГ. Проведена оценка эффективности применения слезозаменителей (препарата Ай-ти Эктоин 0,5% и Ай-ти Эктоин Про 2% глазные капли). Установлено: препараты Ай-ти Эктоин 0,5% и Ай-ти Эктоин 2,0% восстанавливают слезную пленку, увеличивая гидратацию поверхности, стабилизируют липидный слой слезной пленки и снижают осмолярность слезной жидкости. Препарат Ай-ти Эктоин 2,0% улучшает показатели клеточного и гуморального звена местного иммунитета, стабилизирует клеточную мембрану и снижает степень воспаления, стимулирует репаративные процессы роговицы и конъюнктивы.Обоснована необходимость обязательной оценки состояния эпителия конъюнктивы и роговицы, фактора осмолярности слезной жидкости при лечении пациентов с ВЗПГ.
СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ ЛЕЧЕНИЯ ПРОНИКАЮЩИХ РАНЕНИЙ ГЛАЗ С ВОВЛЕЧЕНИЕМ ЗОНЫ ЛИМБА
Authors: Petrenko O.V. , Bondar N.I.
Published: January 2022

Анализ данных литературы показал, что проникающие ранения глаза с вовлечением зоны лимба являются тяжелой формой патологии, обусловленной повреждением сложных анатомических структур (угол передней камеры, цилиарное тело, зона расположения стволовых клеток роговичного фенотипа), что, в ряде случаев, приводит к формированию грубых васкуляризированных рубцов.В связи с тяжестью данного вида проникающих ранений, а также неудовлетворенностью оптического исхода, на сегодняшний день остается актуальным вопрос усовершенствования первичной хирургической обработки проникающих ранений глаза с вовлечением зоны лимба.Существенным фактором, заставившим по-новому посмотреть на эту проблему, явилось открытие стволовых клеток роговичного фенотипа, расположенных в самой периферической зоне роговицы, то есть в области лимба.Изучение литературы показало, что усовершенствование тактики хирургического лечения проникающих ранений с вовлечением зоны лимба далеко себя не исчерпало и не является оптимальным, поэтому требует дальнейшего изучения и совершенствования. Перспективным в вопросе лечения данной патологии является разработка усовершенствованной техники ПХО с применением аутолимбальной трансплантации наложения швов на проникающую рану зоны лимба с применением роговично-конъюнктивального трансплантата.
Порушення агрегації тромбоцитів як чинник розвитку діабетичної макулопатії та діабетичного макулярного набряку у хворих на непроліферативну діабетичну ретинопатію при цукровому діабеті 2-го типу
Authors: Mogilevskyy S.Yu. , Panchenko Yu.O. , Ziablitsev S.V. , Natrus L.V.
Published: January 2022

Актуальність. Аналіз сучасних даних дає можливість висунути припущення, що патогенетичні чинники цукрового діабету (ЦД) можуть провокувати проагрегантний статус тромбоцитів (Тц) та викликати порушення мікроциркуляції в оболонках ока і розвиток діабетичної макулопатії (ДМП) та діабетичного макулярного набряку (ДМН). Мета дослідження — проаналізувати порушення агрегації Тц при ДМН та ДМП за умов непроліферативної діабетичної ретинопатії (НПДР) при ЦД 2-го типу. Матеріали та методи. Дослідження включало 32 хворих (32 ока) із ЦД 2-го типу, у яких за класифікацією ETDRS виявлена легка (14 хворих, 14 очей) і помірна (18 хворих, 18 очей) стадії НПДР. Для дослідження Тц in vitro використовували аденозиндифосфат (АДФ), адреналін, ангіотензин-2 (Анг-2), фактор активації тромбоцитів (ФАТ) і колаген. Оцінку агрегації Тц проводили турбидиметричним методом на аналізаторі Chronolog (США). Результати. У пацієнтів з ДМП при помірній стадії НПДР виявлена більша реактивність Тц до Анг-2, ФАТ і адреналіну, ніж при легкій стадії (p < 0,01). Даний феномен відбивав підвищення агрегації Тц внаслідок порушень симпатоадреналової та ренін-ангіотензинової систем та зростання тяжкості запалення. Гіперреактивність Тц до Анг-2 була причиною розвитку ДМН у хворих з ДМП при помірній стадії НПДР. Висновки. Патогенетичні чинники ЦД можуть провокувати проагрегантний статус Тц і тим самим викликати порушення мікроциркуляції в оболонках ока, що супроводжується розвитком ДМП і ДМН.
Redesign of Leg Prosthetic Clamp Adapter Component Made of Aluminium Mg5085 by using CAD and CAE
Authors: Prabowo Fajar Yulianto , Suyitno S
Published: January 2022

Designing used CAD (Computer Aided Design) to create a design and analyzing the clamp adapter on the leg prosthetic component by using CAE (Computer Aided Engineering) had already been done. This research background is due to a failure on the part of the leg prosthetic component whereas the aim of this research is intended being able to design a leg prosthetic clamp adapter to be able to withstand 300kg load. Aluminium Mg 5085 is the material to make this clamp adapter then 300kg loading test is conducted. 300kg weight is chosen as considered having the average weight of adults who suffer obesity. The result showed that the hugest stress is 25.41 MPa, the biggest displacement 6.876 mm, and 0.1345mm stress. This analysis result is far lower from yield strength aluminium Mg which is 140 MPa. Hence, this design can be said safe and can be tested further.
The Effect of Varying Water to Powder Ratios on the Microhardness and Microstructure of Mineral Trioxide Aggregate
Authors: Den Rethy , Dharmastiti Rini , Nuryono Nuryono , Yuliatun Leny , Widjijono Widjijono
Published: January 2022

The composition of water and powder in a mixture is one of the common problems in application as clinicians typically estimate the ratio chairside. The purpose of this study was to investigate the effect of varying water-to-powder ratios on the microhardness and microstructure of mineral trioxide aggregate (MTA). ROOTDENT MTA was investigated. One gram of cement was mixed with 0.28, 0.33, and 0.40 grams of distilled water and was stored for 1, 7, and 28 days in the water. Samples were subjected to x-ray diffraction (XRD), scanning electron microscopy (SEM), and microhardness tests. Tricalcium silicate, dicalcium silicate, zirconium dioxide, calcium carbonate, and calcium hydroxide were detected by XRD. SEM showed the presence of amorphous, porous capillary channel and capillary structure on the surface of the specimens. The SEM image for each water-to-powder ratio of the surface of the material was indistinguishable from the other. The highest microhardness was exhibited by the MTA specimen with the 0.33 water-to-powder ratio submerged in the water for 28 days.
Pollen in Forensic Palynology: An Exploration into a Crime Solving Tool
Authors: Rakshanda Ammna , Reddy Jayarama
Published: January 2022

Palynology is the study of pollen grain and spores. The term forensic when inserted into the picture marks the usage of pollen into a crime-solving and suspect finding tool. Pollen grain has an outer layer made up of sporopollenin which gives high durability and resistance due to which pollen can survive at adverse and extreme conditions. The samples collected from the crime scene are analysed, studied and investigated along with the samples obtained from the suspects. A relation is derived which acts as evidence during the judicial custody. Pollen analysis is highly useful if a crime that has happened long back, and now needs to be opened up. Advancement of this technique in India is still awaited.
Detection of eating problems and their relationship with eating habits in adolescents / Detección de problemas alimentarios y su relación con hábitos alimentarios en adolescentes
Authors: Guerrero-Cuevas Belén , Valero-Aguayo Luis , Solano-Martínez Diego , Priore-Molero Claudio , Perea-Barba Adrián , Afán de Rivera María De los Ángeles
Published: January 2022

Se ha realizado un estudio de detección de trastornos alimentarios en adolescentes, estudiando su posible relación con los hábitos alimentarios en los colegios.  Han participado 3145 alumnos/as (49.7% chicas y 50.3% chicos) de 16 colegios de secundaria, con edades entre 13 y 17 años (media de 14.4 años). Los datos se recopilaron entre 2013 a 2017. Se han registrado distintas variables sociodemográficas, el IMC y los cuestionarios EAT-40 y BSQ. También se registró el tipo de ingesta en el desayuno y en el recreo de todos los alumnos/as el día de la evaluación. En los resultados aparecen diferencias significativas en el EAT-40 y BSQ, donde siempre hay mayor proporción de chicas que superan el punto de corte. Respecto al IMC, un 17.7% tiene peso insuficiente, un 20.3% con sobrepeso y un 7.0% con obesidad, y también con diferencias entre chicos y chicas, pues estas presentan un IMC mayor. A partir de todos los datos, podría considerarse que hay un porcentaje de 5.6% de participantes con posibles trastornos de conducta alimentaria, en mayor proporción en mujeres (9.6%) que en hombres (1.8%), porcentajes que han ido descendiendo a lo largo de los años. No hay correlación con los hábitos alimentarios, pero hay mayor proporción de chicas que toman menos comidas y bebidas durante el desayuno y el recreo. Un dato alarmante es que un 5.6% de las chicas y un 2.5% de los chicos no desayunan absolutamente nada durante toda la mañana escolar.
Evaluación Energética y Económica de Calefacción de Hogares por Bomba de Calor en Bariloche, Montevideo y Santiago
Authors:   Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales, Argentina, Juanicó Luis E. , Bove I. ,   Laboratorio de Energía Solar, Facultad de Ingeniería, Universidad de la República, Uruguay
Published: January 2022

El cambio climático obliga a mejorar la eficiencia del consumo de energía. En este trabajo se desarrolla una metodología de evaluación energética y económica de las ventajas de sustituir sistemas de calefacción tradicionales de gas natural, GLP, o electricidad, por una moderna bomba de calor (inverter). Al ser su eficiencia función de la diferencia de temperaturas entre el ambiente exterior y el interior, la eficiencia varía según la ubicación de la ciudad. De esta manera, se estudia su rendimiento en Bariloche, Santiago de Chile y Montevideo (temperatura media anual de 8,3; 14,6 y 16,3 °C, respectivamente), empleando los siguientes sistemas: 1) aire-aire, instalando varios equipos Split; y 2) aire-agua, instalando una bomba de calor que brinde calefacción por radiadores de agua. Esta metodología permite dimensionar estos sistemas y calcular el ahorro anual, ejemplificándose para una vivienda social de 50 m2. En todos los casos estudiados se alcanzaron reducciones de los consumos y ahorros de moderados a notables (y períodos de repago de la inversión menores a dos años), excepto contra el gas natural en Bariloche y Montevideo. Se discute también cómo su inversión moderada puede constituir una primera solución asequible, frente a la costosa rehabilitación térmica, a fin de obtener viviendas más sustentables.
A Study on Customer Satisfaction towards Banking Services Provided by SBI in Reference with Erode City
Authors: Kumar P. Satheesh
Published: January 2022

Abstract: The study is conducted on the consumer satisfaction towards the services rendered by SBI. SBI is an Indian multinational, public sector banking and financial services statutory body. They have branches spread over the entire length and breadth of the country. SBI in particular is all pervasive enjoying a sprawling network of 9000 branches. It has assets to be worth of about Rs.2,22,500 crore. SBI has very conservative approach to accounting particularly when it comes to declaration of its assets. SBI enjoys a monopoly of the government business. The reserve bank of India owns about 60%of the banks equity. SBI was formed under the SBI act in 1955. With the takeover of imperial bank and amalgamation of Bank of Bengal, Bank of Bombay and Bank of Madras. SBI enjoys a pool of best managerial talent, assured government business, a country wide network of branches and strong brand credibility in the Indian market. Keywords: Public sector banking, Financial services, imperial bank
COUNTING GAME APPLICATION FOR KINDERGARTEN CHILDREN
Authors: Ade Putra Teri , Ayu Mahessya Raja , Elva Yesri , Ayu Widya Purnama Pradani
Published: January 2022

Problems The development of Information Technology plays an important role in human life. With the development of Information Technology, humans can easily get information and humans can easily carry out daily activities with the help of existing technology. Technology brings people to see the outside world further, open their minds to think, and build creativity to create new things, one of the technologies that is currently developing very rapidly is smartphone-based technology, especially Android. Many android applications are very helpful at this time such as health applications, transportation and there are also educational games. Educational games can make it easier to learn, sometimes when learning someone will be faced with conditions where it is difficult to understand the lesson, so with the educational game it is hoped that it can help users understand the lessons in the game, besides that educational games are a very fun learning tool for students. , because students will be happier and easier to understand by playing while learning
MÃES QUE PERDERAM FILHOS ADULTOS: UM GRUPO FOCAL
Authors: Saft Eduarda Camila , Albuquerque Flávia Michelle Pereira
Published: January 2022

Death, although being part of human development, in its last stage, it is still not so debated in social circles, being associated to pain and suffering, because it characterizes the breaking of affective bonds, besides making us remember of our own finitude. When a mother loses her son, she faces a lacerating pain, as if one part of her has died together with her son, it lacks words to define such pain. The present is a qualitative, exploratory, descriptive and field research. The data collection was conducted through a focal group with four mothers who lost their children during adult stage, who have passed away at least five years ago, women who reside in a municipality in the northeast of Rio Grande do Sul state. The analysis and interpretation of data was carried out with content analysis. The relevance of this study resides in the possibility of producing reflections about maternal mourning allowing planning of actions which involve the mourners, family and community promoting health, resignification of feelings and completeness of the individual.
Injectivity and Nuclearity Properties for Real C*-Algebras
Authors: Rakhimov A. A. , Nurillaev M. E. , Boltaev Kh. Kh.
Published: January 2022

In this paper, we study injective and nuclear real W*- and C*-algebras. The connection of these concepts with similar concepts of enveloping W*- and C*-algebras is considered. The equivalence of the concepts of injectivity and nuclearity for real C*-algebras is shown. As a consequence, nuclear real factors of types II1, II, III1, III0 and III (0 1) are completely described.
Las formas de propiedad de los medios de comunicación. Estado de la cuestión
Authors: Gallego Ramos José Raúl
Published: January 2022

El objetivo de este artículo es presentar un estado de la cuestión sobre las distintas modalidades de propiedad mediática reconocidas en la literatura científica. A raíz de los procesos de concentración de medios que se han experimentado en las últimas décadas y el surgimiento de leyes que regulan este aspecto, el estudio de las formas de propiedad mediática se ha convertido en un tema de importancia para el campo de la comunicación por la influencia de la propiedad en la calidad del periodismo y la democracia. Sin embargo, muchas investigaciones adolecen de indefinición teórica, escasa problematización de la categoría, colisiones terminológicas y no abundan los trabajos dedicados a compendiar y sistematizar las diferentes modalidades de propiedad mediática que existen en la actualidad. La metodología empleada para construir el estado de la cuestión que aquí se presenta fue la revisión bibliográfico-documental. El análisis de investigaciones generadas en diferentes áreas del campo de la comunicación, posibilitó identificar y recuperar los rasgos básicos de las formas de propiedad mediática caracterizadas en este artículo. De ahí que el principal valor de este estudio radica en reunir, sistematizar y caracterizar, a partir de seis dimensiones estandarizadas, las nueve principales formas de propiedad bajo las que operan los medios de comunicación: privada individual, privada colectiva, fundaciones sin fines de lucro, cooperativa,  organizaciones mediáticas no lucrativas, comunitaria, de organizaciones políticas y la sociedad civil, pública y estatal.
SÍNTESE DE NANOESTRUTURAS DE COBRE E NÍQUEL PARA OBTENÇÃO DE NANOCATALISADORES PARA CONVERSÃO DE BIOMASSA
Authors: De Lima Karina Muniz , Costa Lídia Oazem de Oliveira da , Moreira Carla Ramos , Farias Andréa Maria Duarte de
Published: January 2022

Catalisadores a base de cobre e níquel podem ser considerados uma alternativa barata em comparação ao emprego de metais nobres. A obtenção de nanopartículas de cobre/óxido de cobre e níquel/óxido e níquel com morfologia controlada e bem dispersas para uso como núcleos numa arquitetura do tipo casca-núcleo (core eyolk-shell) pode ser interessante no controle da lixiviação, problema recorrente nas reações em fase líquida. O monitoramento destes materiais para avaliar o sucesso da preparação e a estabilidade da estrutura deve ser realizado por microscopia eletrônica. Neste trabalho, os resultados indicaram que o controle de parâmetros como temperatura, estabilizante e agente redutor utilizados, leva ao controle da etapa de crescimento das nanopartículas metálicas. Os protocolos de síntese foram padronizados visando a obter catalisadores para aplicação no reaproveitamento da biomassa vegetal.
Pengaruh kepuasan kerja terhadap kinerja dengan komitmen organisasi sebgai variabel intervening (studi pada mitra bangunan Kota Jambi)
Authors: Putra Anjas Kesuma , Jaya Indra , Wilian Rohman
Published: January 2022

This research was conducted to describe and explore in-depth the variable descriptions of job satisfaction, organizational commitment, and employee performance in the Jambi city supermarket building partners as well as the influence caused by job satisfaction on organizational commitment, the effect of job satisfaction on employee performance, the influence of organizational commitment on employee performance, and the effect of job satisfaction on employee performance with organizational commitment as an intervening variable. The number of samples in the study was 127 employees of Jambi city supermarket building partners. This research method is quantitative research. The findings in this study indicate that the variable descriptions of job satisfaction, organizational commitment, and employee performance at Mitra Bangunan Supermarket Jambi are categorized as high. High predict rate. As for the influence between variables, it shows that job decision variables have a positive and significant effect on performance, while for the mediating variables that indirectly affect job satisfaction on performance, it is significant, so it can be concluded that organizational commitment has an indirect effect on job satisfaction on employee performance.
Pengaruh kompensasi terhadap kompetensi guru melalui motivasi sebagai variabel intervening di SD Negeri 228 Sarolangun
Authors: Rahim Kasmir , Rosita Sry , Sumarni Sumarni
Published: January 2022

This study aims to determine the effect of compensation on teacher competence through motivation as an intervening variable at SD N 228 Sarolangun. The sample in the study amounted to 15 people. The data collection method used a literature study and questionnaires, measured by the Likert scale. Analysis using descriptive and quantitative analysis using the analysis tool is SmartpPLS 3.0. Based on the results of research conducted on the Effect of Compensation on Competence through Motivation as an Intervening Variable at SD N 228 Sarolangun. Then the results obtained show that compensation has a positive and insignificant effect on teacher competence, compensation has a positive and significant effect on motivation, and work motivation has a positive and insignificant effect on competence. The results show that compensation through motivation as an intervening variable has a positive and insignificant effect on teacher competence in SD N 228 Sarolangun.
Pengaruh disiplin kerja dan komitmen organisasi terhadap kinerja pegawai pada kantor Dinas Pemberdayaan Masyarakat dan Pemerintahan Dusun Kabupaten Muara Bungo
Authors: Hidayat Berryansyah , Amin Shofia , Rosita Sry
Published: January 2022

Organizational commitment on employee performance at the Office of Community Empowerment and the Dusun Government of Muara Bungo Regency. The approach used in this research is a quantitative approach with associative analysis. The sampling technique used was saturated sampling. The number of samples taken in this study was all employees totaling 34 respondents. The results showed that the work discipline variable had a negative and insignificant effect on performance, and the organizational commitment variable showed a positive and significant impact on performance. The study results indicate that the variables of work discipline and organizational commitment together affect the performance of employees at the Office of Community Empowerment and the Dusun Government of Muara Bungo Regency.
Pengaruh country of origin ( asal negara produk ) harga dan kualitas terhadap keputusan pembelian alat tulis
Authors: Habiburrahman Habiburrahman , Raf Mulyadi , Kartika Syilvia
Published: January 2022

One of effect the open market is the entry of products originating from abroad, which directly or indirectly can affect the local product of the country. The object of this research is the stationery product, the stationery is chosen because it is one of the products that closest to daily student activities as respondents to this study. The purpose of this study is to determine the effect of country of origin price and product quality influence partial or simultaneous in purchasing decision of stationery, and to know what most variable influential to purchasing stationery. Analyze appliance used in this research is Multiple Linear Regression by using the analysis tool is the result of this study is the variable of country of origin and quality partially have a positive and simultaneous influence on the purchasing decision of stationery. While the price variable partially have a positive but not significant effect on the purchasing decision of stationery, if tested simultaneously then country of origin variable of price and quality have positive and significant effect to decision of stationery. For the most influential variable in the purchase of stationery in this study is the quality variable. Based on this research the stationery company besides having to continuously improve the quality of its products also enter the country identity because country of origin which owned by consumer can influence consumer purchasing decision.
Pengaruh kompensasi terhadap komitmen organisai karyawan pada PT. Honda Wiltop Auto Jambi
Authors: Sari Liza Amelia , Rosita Sry , Hasanah Nur
Published: January 2022

This research aims to know the compensation influence on employees' organizational commitment. This study involved 58 respondents who are employees of PT. Honda Wiltop Auto Jambi. A detailed questionnaire has used as a data collection method, while the analysis method used simple linear regression. The result showed which compensation has a significant positive effect on organizational commitment. The value of the t causes it is significantly larger than the t quantification, the variable compensation of 0.553 regression, which means that the better system of awarding prizes will increase the organization's commitment by 0.553. The resulting value of R square on 0.363 means that contribution of compensation on 36.43% informing organizational commitment variable, and forming the rest by the outside variable of this study.
ERRATA: TREINADORAS E AUXILIARES DO FUTEBOL DE MULHERES NO BRASIL: SUBVERSÃO E RESISTÊNCIA NA LIDERANÇA ESPORTIVA
Authors: Editorial Comissão
Published: January 2022

No artigo "TREINADORAS E AUXILIARES DO FUTEBOL DE MULHERES NO BRASIL: SUBVERSÃO E RESISTÊNCIA NA LIDERANÇA ESPORTIVA", com número de DOI: 10.22456/1982-8918.106782, publicado no periódico Movimento, 27(1):e27023, na página 1:Onde se lia:“Bárbara Aparecida Beples Pires”Leia-se:“Bárbara Aparecida Bepler Pires”
Long-term cattle grazing shifts the ecological state of forest soils
Authors: Proesmans Willem , Andrews Christopher , Gray Alan , Griffiths Rob , Aidan Keith , Neilsen Uffe , Spurgeon David J , Pywell Richard , Emmett Bridget , Vanbergen Adam
Published: January 2022

1. Cattle grazing profoundly affects abiotic and biotic characteristics
of ecosystems. While most research has been performed on grasslands, the
effect of large managed ungulates on forest ecosystems has largely been
neglected. 2. Compared to a baseline semi-natural state, we investigated
how long-term cattle grazing of birch forest patches affected the
abiotic state and the ecological community (microbes and invertebrates)
of the soil subsystem. 3. Grazing strongly modified the soil abiotic
environment by increasing phosphorus content, pH and bulk density, while
reducing the C:N ratio. The reduced C:N-ratio was strongly associated
with a lower microbial biomass, mainly caused by a reduction of fungal
biomass. This was linked to a decrease in fungivorous nematode abundance
and the nematode channel index, indicating a relative uplift in the
importance of the bacterial energy-channel in the nematode assemblages.
4. Cattle grazing highly modified invertebrate community composition
producing distinct assemblages from the semi-natural situation. Richness
and abundance of microarthropods was consistently reduced by grazing
(excepting collembolan richness) and grazing-associated changes in soil
pH, Olsen P and reduced soil pore volume (bulk density) limiting niche
space and refuge from physical disturbance. Anecic earthworm species
predominated in grazed patches, but were absent from ungrazed forest,
and may benefit from manure inputs, while their deep vertical burrowing
behaviour protects them from physical disturbance. 5. Perturbation of
birch forest habitat by long-term ungulate grazing profoundly modified
soil biodiversity, either directly through increased physical
disturbance and manure input or indirectly by modifying soil abiotic
conditions. Comparative analyses revealed the ecosystem engineering
potential of large ungulate grazers in forest systems through major
shifts in the composition and structure of microbial and invertebrate
assemblages, including the potential for reduced energy flow through the
fungal decomposition pathway. The precise consequences for trophic
interactions and biodiversity-ecosystem function relationships remains
to be established, however.
Spindle cell lipoma: An uncommon variant of lipoma affecting the foot sole
Authors: Salah Nesrine Ben , Lahouel Ines , Manaa Linda , Youssef Monia , hajali hichem , Zili Jameleddine
Published: January 2022

We report a 36-year-old male with an atypical variant of lipoma
occurring on an atypical site.
Music-theoretical writings of Vlastimir Trajkovic as a reflection of his advocating for a new recognition of Serbian art music
Authors: Jankovic-Begus Jelena
Published: January 2022

In this paper I analyse selected articles by the composer and academician
Vlastimir Trajkovic (1947-2017), published in various collective monographs
and journals over the period of nearly three decades (1982-2008). These
writings emphasise Trajkovic?s constant urging for a fairer (from his point
of view) evaluation of Serbian art music in a wider, European and global
context, but also within the state/national frameworks. Trajkovic aimed to
prove that Serbian art music, as well as writings on music, would have
enjoyed a wider recognition, had certain of their top achievements not been
left forgotten and unpublished, and thus unavailable to potential
researchers and performers. That is why he pleaded for the improvement of
sheet music publishing in the country, as well as for the targeted promotion
of Serbian art music repertoire. Moreover, he insisted on the proximity of
the Belgrade ?cultural climate? in the interwar period with the artistic and
scholarly tendencies in France and its ?zones of influence? in the same
period. Consequently, Trajkovic particularly insists on the new evaluation
of the opuses of the composers and musicologists Miloje Milojevic
(1884-1946) and Dragutin Gostuski (1923-1998) - whom he saw as those
creative and intellectual individuals who had fallen victims to the
?historical injustice? and whose (re)positioning within the Serbian music
culture would increase the relevance of that same culture both in the
national and international contexts.
Case report of a patient with toxic epidermal necrolysis with complications and review of literature
Authors: Petrovic-Popovic Dragana , Petrovic-Elbaz Mirjana
Published: January 2022

Introduction. Toxic epidermal necrolysis (TEN), also known as Lyell?s syndrome, is a rare exfoliative disorder with a high mortality rate. This entity was first described by Lyell in 1956, who termed the condition ?toxic epidermal necrolysis,? pointing out that drug sensitization was generally considered to be the mechanism leading to this syndrome. The drugs most frequently involved are nonsteroidal anti-inflammatory drugs (NSAID), chemotherapeutic agents, antibiotics, and anticonvulsants, although viral, bacterial, and fungal infections, as well as immunization, have been described. Case outline. We present a 72-year-old man with the following history. Five days before he was admitted, the patient had high fiver and sore throat. He was treated with antibiotics and NSAID because he had bronchopneumonia, after which he developed itchy skin rash all over his body, followed by the sensation of slight sore throat, with conjunctival hyperemia and hard breathing and high fiver, due to which he was hospitalized in the local hospital. After worsening of the symptoms, followed by urticaria-like plaques and bullae with progress all over the body, the patient was moved to our institution and placed in the Intensive Care Unit, under suspicion of TEN. The aim of the paper presented here is to give a thorough summary of our literature review searching for the best therapy modalities for our patient with TEN. Conclusion. Our standpoint is that TEN patients with multiorgan system lesions, with 80% of the total body surface area affected, and with SCORTEN scale score of 4 can be successfully treated if diagnosed early.
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Authors: Dollet Lucile , Kuefner Michael , Caria Elena , Rizo-Roca David , Pendergrast Logan , Abdelmoez Ahmed M. , Karlsson Håkan K.R. , Bjrnholm Marie , Dalbram Emilie , Treebak Jonas T. , Harada Jun , Näslund Erik , Rydén Mikael , Zierath Juleen R. , Pillon Nicolas J. , Krook Anna
Published: January 2022

Dysregulation of skeletal muscle metabolism influences whole-body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes–associated alterations in the plasma metabolome directly contribute to skeletal muscle immunometabolism and the subsequent development of insulin resistance. To this end, we analyzed the plasma and skeletal muscle metabolite profile and identified glutamine as a key amino acid that correlates inversely with BMI and insulin resistance index (HOMA-IR) in men with normal glucose tolerance or type 2 diabetes. Using an in vitro model of human myotubes and an in vivo model of diet-induced obesity and insulin resistance in male mice, we provide evidence that glutamine levels directly influence the inflammatory response of skeletal muscle and regulate the expression of the adaptor protein GRB10, an inhibitor of insulin signaling. Moreover, we demonstrate that a systemic increase in glutamine levels in a mouse model of obesity improves insulin sensitivity and restores glucose homeostasis. We conclude that glutamine supplementation may represent a potential therapeutic strategy to prevent or delay the onset of insulin resistance in obesity by reducing inflammatory markers and promoting skeletal muscle insulin sensitivity.
Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target
Authors: Garranzo-Asensio María , Solís-Fernández Guillermo , Montero-Calle Ana , García-Martínez José Manuel , Fiuza Maria Carmen , Pallares Pilar , Palacios-Garcia Nuria , García-Jiménez Custodia , Guzman-Aranguez Ana , Barderas Rodrigo
Published: January 2022

Colorectal cancer (CRC) and diabetes are two of the most prevalent chronic diseases worldwide with dysregulated receptor tyrosine kinase signaling and strong co-occurrence correlation. Plasma autoantibodies represent a promising early diagnostic marker for both diseases before symptoms appear. In this study, we explore the value of autoantibodies against receptor-type tyrosine-protein phosphatase-like N (PTPRN; full-length or selected domains) as diagnostic markers using a cohort of individuals with type 2 diabetes (T2D), CRC, or both diseases or healthy individuals. We show that PTPRN autoantibody levels in plasma discriminated between patients with T2D with and without CRC. Consistently, high PTPRN expression correlated with decreased survival of patients with CRC. Mechanistically, PTPRN depletion significantly reduced invasiveness of CRC cells in vitro and liver homing and metastasis in vivo by means of a dysregulation of the epithelial-mesenchymal transition and a decrease of the insulin receptor signaling pathway. Therefore, PTPRN autoantibodies may represent a particularly helpful marker for the stratification of patients with T2D at high risk of developing CRC. Consistent with the critical role played by tyrosine kinases in diabetes and tumor biology, we provide evidence that tyrosine phosphatases such as PTPRN may hold potential as therapeutic targets in patients with CRC.
A Cycle of Inflammatory Adipocyte Death and Regeneration in Murine Adipose Tissue
Authors: Monji Akio , Zhang Yang , Kumar G.V. Naveen , Guillermier Christelle , Kim Soomin , Olenchock Benjamin , Steinhauser Matthew L.
Published: January 2022

Adipose tissue (AT) expands by a combination of two fundamental cellular mechanisms: hypertrophic growth of existing adipocytes or through generation of new adipocytes, also known as hyperplastic growth. Multiple lines of evidence suggest a limited capacity for hyperplastic growth of AT in adulthood and that adipocyte number is relatively stable, even with fluctuations in AT mass. If the adipocyte number is stable in adulthood, despite well-documented birth and death of adipocytes, then this would suggest that birth may be coupled to death in a regenerative cycle. To test this hypothesis, we examined the dynamics of birth of new fat cells in relationship to adipocyte death by using high-fidelity stable isotope tracer methods in C57Bl6 mice. We discovered birth of new adipocytes at higher frequency in histological proximity to dead adipocytes. In diet-induced obesity, adipogenesis surged after an adipocyte death peak beyond 8 weeks of high-fat feeding. Through transcriptional analyses of AT and fractionated adipocytes, we found that the dominant cell death signals were inflammasome related. Proinflammatory signals were particularly evident in hypertrophied adipocytes or with deletion of a constitutive oxygen sensor and inhibitor of hypoxia-inducible factor, Egln1. We leveraged the potential role for the inflammasome in adipocyte death to test the adipocyte death-birth hypothesis, finding that caspase 1 loss of function attenuated adipocyte death and birth in murine visceral AT. These data collectively point to a regenerative cycle of adipocyte death and birth as a driver of adipogenesis in adult murine AT.
Endosomal Sequestration of TLR4 Antibody Induces Myeloid-Derived Suppressor Cells and Reverses Acute Type 1 Diabetes
Authors: Locker Kathryn C.S. , Kachapati Kritika , Wu Yuehong , Bednar Kyle J. , Adams David , Patel Caroline , Tsukamoto Hiroki , Heuer Luke S. , Aronow Bruce J. , Herr Andrew B. , Ridgway William M.
Published: January 2022

We previously showed that treating NOD mice with an agonistic monoclonal anti-TLR4/MD2 antibody (TLR4-Ab) reversed acute type 1 diabetes (T1D). Here, we show that TLR4-Ab reverses T1D by induction of myeloid-derived suppressor cells (MDSCs). Unbiased gene expression analysis after TLR4-Ab treatment demonstrated upregulation of genes associated with CD11b+Ly6G+ myeloid cells and downregulation of T-cell genes. Further RNA sequencing of purified, TLR4-Ab–treated CD11b+ cells showed significant upregulation of genes associated with bone marrow–derived CD11b+ cells and innate immune system genes. TLR4-Ab significantly increased percentages and numbers of CD11b+ cells. TLR4-Ab–induced CD11b+ cells, derived ex vivo from TLR4-Ab–treated mice, suppress T cells, and TLR4-Ab–conditioned bone marrow cells suppress acute T1D when transferred into acutely diabetic mice. Thus, the TLR4-Ab–induced CD11b+ cells, by the currently accepted definition, are MDSCs able to reverse T1D. To understand the TLR4-Ab mechanism, we compared TLR4-Ab with TLR4 agonist lipopolysaccharide (LPS), which cannot reverse T1D. TLR4-Ab remains sequestered at least 48 times longer than LPS within early endosomes, alters TLR4 signaling, and downregulates inflammatory genes and proteins, including nuclear factor-κB. TLR4-Ab in the endosome, therefore, induces a sustained, attenuated inflammatory response, providing an ideal “second signal” for the activation/maturation of MDSCs that can reverse acute T1D.
“I’m Going to Be Good to Me”: Exploring the Role of Shame and Guilt in Patients With Type 2 Diabetes
Authors: Solomon Ellen , Salcedo Venise J. , Reed Megan K. , Brecher Alison , Armstrong Elizabeth M. , Rising Kristin L.
Published: January 2022

Objective. People with type 2 diabetes are likely to
experience shame or guilt as they navigate through their disease. Previous
research has shown that feelings of shame and guilt often exist within the
clinician-patient relationship, often as a result of the complex care regimen
required to achieve treatment goals. The purpose of this qualitative study was
to explore patients’ experiences of shame and guilt in type 2 diabetes
management and the impact their clinicians have on these experiences.

Methods. Semi-structured interviews were used to
explore patients’ experiences with shame and guilt. Interviews were
audio-recorded, transcribed, and coded using directed content analysis.
Demographic data were also obtained.

Results. We completed 20 interviews with people with
type 2 diabetes (65% Black, 70% female). Participants exhibited feelings more
consistent with guilt than with shame. All participants discussed how their
clinicians affected these feelings. Patients who expressed feelings of guilt
were able to recognize opportunities for behavior change without experiencing
global devaluation, in which they linked their actions to an unchangeable
aspect of their identity or personality, often describing their guilt as
motivating of change. Unlike guilt, when patients experienced shame, they often
exhibited global devaluation, in which they blamed their personality,
experienced hopelessness, and increased maladaptive behaviors.

Conclusion. Our findings
highlight a notable difference between shame and guilt in the context of type 2
diabetes management. We believe that incorporation of an understanding of these
nuances, along with ideal responses to both shame and guilt, will enhance
clinicians’ ability to provide high-quality patient-centered care to people
with diabetes.
Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study
Authors: Jacobsen Laura M. , Vehik Kendra , Veijola Riitta , Warncke Katharina , Toppari Jorma , Steck Andrea K. , Gesualdo Patricia , Akolkar Beena , Lundgren Markus , Hagopian William A. , She Jin-Xiong , Rewers Marian , Ziegler Anette G. , Krischer Jeffrey P. , Larsson Helena Elding , Haller Michael J. , Group the TEDDY Study
Published: January 2022

Objective: The Environmental Determinants
of Diabetes in the Young (TEDDY) study is uniquely capable of investigating age-specific
differences associated with type 1 diabetes. As age is a primary driver of
heterogeneity in type 1 diabetes, we sought to characterize by age, metabolic
derangements prior to diagnosis and clinical features associated with diabetic
ketoacidosis (DKA).

Research Design and
Methods:
The 379 TEDDY children who developed type 1 diabetes were grouped by age at onset
(0-4, 5-9, and 10-14 years; n=142, 151 and 86, respectively) with comparisons
of autoantibody profiles, HLA, family history of diabetes, presence of DKA,
symptomatology at onset, and adherence to TEDDY protocol. Time-varying analysis
of those with OGTT data was compared to TEDDY children who did not progress to
diabetes.

Results: Increasing fasting
glucose (HR=1.09 (95% CI 1.04-1.14), p=0.0003), stimulated glucose (HR=1.50 (1.42-1.59),
p<0.0001), fasting insulin (HR=0.89 (0.83-0.95), p=0.0009), and glucose-to-insulin
ratio (HR=1.29 (1.16-1.43), p<0.0001) were associated with risk of
progression to type 1 diabetes. Younger children had fewer autoantibodies with more symptoms
at diagnosis. Of 23/379 (6.1%) children with DKA at onset, only 1/23 (4.3%) had
a first-degree relative (FDR) with type 1 diabetes compared to 102/356 (28.7%) FDR children without DKA (p=0.008).
Children in DKA were more likely to be non-adherent to study protocol (p=0.047),
with longer duration between their last TEDDY evaluation and diagnosis (median
10.2 vs 2.0 months without DKA, p<0.001).

Conclusions: DKA at onset in TEDDY
is uncommon, especially for FDRs. For those without familial risk, metabolic monitoring
continues to provide a primary benefit of reduced DKA but requires regular
follow-up. Clinical and laboratory features vary by age at onset adding to the
heterogeneity of type 1 diabetes.