bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimento didático de baixo custo para determinação do perfil de temperatura de uma aleta exposta ao ar ambiente
Authors: Letizia Garcia Renato , Sauer Marco César , Aislan Amaral Rafael , Silva Zabadal Jorge Rodolfo
Published: December 2021

O ARTIGO DESCREVE UM EXPERIMENTO DIDÁTICO DE BAIXO CUSTO, NO QUAL AS TEMPERATURAS NUMA ALETA, EXPOSTA AO AMBIENTE, CONVECÇÃO NATURAL E REGIME PERMANENTE, SÃO REGISTRADAS COM CÂMERA TERMOGRÁFICA. PARA A REALIZAÇÃO DOS ENSAIOS, FOI CONFECCIONADO UM EQUIPAMENTO CONSTITUÍDO POR UMA CAIXA DE ISOPOR E UMA HASTE CILÍNDRICA DE ALUMÍNIO, PINTADA DE PRETO, ENGASTADA NESSA CAIXA. A PORÇÃO INSERIDA NA CAIXA ¬FICOU IMERSA EM UM BANHO DE ÁGUA COM TEMPERATURA CONTROLADA, E O PERFIL DE TEMPERATURA NA PORÇÃO EXPOSTA AO AR FOI DETERMINADO. OS DADOS EXPERIMENTAIS FORAM CONFRONTADOS COM VALORES PREVISTOS, NO MODELO TEÓRICO TRADICIONAL, QUE CONSIDERA APENAS A TRANSFERÊNCIA CONVECTIVA DE CALOR NA SUPERFÍCIE DA ALETA E, COM UM MODELO MODIFICADO, NO QUAL TAMBÉM É COMPUTADA A TRANSFERÊNCIA RADIANTE DE CALOR NESSA SUPERFÍCIE. OS RESULTADOS OBTIDOS INDICAM A NECESSIDADE DE CONSIDERAR A TRANSFERÊNCIA DE CALOR POR RADIAÇÃO E A ADEQUABILIDADE DA METODOLOGIA PROPOSTA NA DETERMINAÇÃO DO PERFIL DE TEMPERATURA EM ALETAS E DO EMPREGO DO EXPERIMENTO PARA ¬FINS DIDÁTICOS.

PALAVRAS-CHAVE: ALETAS. CONVECÇÃO DO CALOR. RADIAÇÃO DO CALOR.
PELATIHAN PEMBUATAN KERAJINAN TANGAN MENGGUNAKAN LIMBAH RUMAH TANGGA (SAMPAH PLASTIK) DI KELURAHAN NIKAN JAYA KECAMATAN LUBUKLINGGAU TIMUR I
Authors: Trianah Yeni , Sani Santi
Published: December 2021

Kegiatan ini bertujuan untuk memberikan pelatihan dan keterampilan kepada masyarakat kelurahan Nikan Jaya dalam memanfaatkan sampah plastik menjadi barang kerajinan tangan yang bernilai ekonomi tinggi. Kegiatan ini dilaksanakan pada bulan Maret  2020 yang mencakup sosialisasi, pelatihan, pembinaan, dan evaluasi. Kegiatan ini diikuti oleh 20 peserta yang terdiri atas kelompok remaja putri dan ibu rumah tangga. Peserta berasal dari kelurahan nikan jaya dan sekitarnya. Pelatihan ini menggunakan pendekatan Forum Group Discussion. Sosialisasi yang diberikan mencakup dampak negatif sampah plastik bagi lingkungan, berbagai potensi pemanfaatan sampah plastik, kegiatan dilanjutkan dengan demonstrasi pembuatan kerajinan tangan. Kemudian dilanjutkan dengan pelatihan pembuatan barang kerajinan tangan. Hasil survei menunjukkan peserta sangat antusias dan memberikan respon yang cukup baik selama kegiatan berlangsung maupun setelahnya. Selain itu, permintaan untuk tetap dilakukannya pembinaan hingga peserta benar-benar terampil membuat barang kerajinan tangan.
PELATIHAN GURU BK SMP DI BEKASI UNTUK MELAKUKAN BIMBINGAN KELOMPOK
Authors: Hanim Wirda , Karsih Karsih
Published: December 2021

Kendala yang dihadapi selama ini pelayanan bimbingan kelompok jarang dilakukan selain soal terbatasnya waktu layanan adalah ketrampilan guru BK di SMP. Kondisi ini juga menjadi lebih sulit karena pelayanan bimbingan kelompok pada masa pandemi. Sasaran pengabdian ini yaitu guru BK di bekasi. Oleh karena itu, dengan tujuan meningkatkan kertampilan guru BK dalam memberikan layanan bimbingan kelompok maka dibuat pengabdian ini. Pengabidan pada awalnya didesain dengan sistem luring (offline), akan tetapi dengan adanya masa pandemi maka layanan berubah menjadi daring (online). Tahap yang dilakukan sama sesuai rencana awal yaitu asesmen, workhsop, praktik dan evaluasi. Dari hasil asesmen hingga tahap ini dihasilkan 5 kelompok dengan model kelompok gabungan. Per satu kelompok dibuat berisi 10 orang siswa yang berasal dari 2 sekolah kecuali SMP 19 Jakarta yang homogen dalam satu sekolah. Siswa yang terlibat semua berasal dari kelas 7. Berdasarkan aspek proses kegiatan pengabidian berjalan dengan baik. Berdasarkan aspek hasil, terget yang diharapkan tercapai dari pengabdian ini yaitu guru BK meningkat kertampilan untuk melakukan bimbingan kelompok dan terjadi perubahan kondisi empati siswa.

Kata kunci: Bimbingan Kelompok, Empati, Ketrampilan, Guru
PKM-PENINGKATAN KETERAMPILAN GURU MATEMATIKA SMK KABUPATEN MAJENE DALAM PENGGUNAAN GEOENZO SEBAGAI MEDIA PEMBELAJARAN MATEMATIKA
Authors: Syamsuddin Syamsuddin , Ahmad Herlina , Hasliana Lili , Latif Abdul , Tasni Nurfaida
Published: December 2021

Guru matematika SMK Kabupaten majene berjumlah 30 orang yang tersebar dari 10 sekolah negeri dan swasta. Berdasarkan hasil diskusi dengan MGMP Matematika SMK Kabupaten Majene, yang merupakan wadah guru matematika untuk melakukan kegiatan yang dapat meningkatkan kompetensi guru matematika SMK di Kabupaten Majene. Diperoleh data pemanfaatan aplikasi matematika belum optimal dilakukan oleh guru, hal ini disebabkan ketidak mampuan guru menggunakan aplikasi matematika dalam proses pembelajaran. Hal ini bertolak belakang dengan era teknologi seperti sekarang ini, banyak software matematika gratis yang adapat membantu guru dalam menjelaskan konsep matematika. GeoEnzo salah satu software matematika  gratis yang dapat dijadikan media pembelajaran matematika. GeoEnzo memudahkan guru untuk menampilkan gambar bangun datar serta bangun ruang dan tentunya memudahkan guru dalam menyampaikan konsep matematika. Metode yang digunakan dalam PkM ini adalah Forum Group Discussion (FGD) ceramah, pelatihan dan pendampingan. Tahap pelaksanaan PkM meliputi (1) koordinasi dan analisis kebutuhan usulan, (2) menyusun dan validasi modul GeoEnzo, (3) pelatihan penggunaan GeoEnzo, (4) Pendampingan di kelas penggunaan GeoEnzo, (5) Evaluasi dan (6) pelaporan pelaksanaan kegiatan. Hasil analisis dari angket sebelum dan sesudah dilakukan kegiatan pelatihan dan pendampingan penggunaan GeoEnzo sebagai media pembelajaran, diperoleh keterampilan menggunakan GeoEnzo meningkat dari 0% menjadi 100%.
Sosialisai Gerakan 3M Guna Memutus Penularan Covid-19 di Kelurahan Talang Ubi Selatan PALI
Authors: Nurdiana Nita , Sariutami Fuji , Cindy P Tiara Nicky , Mawardy Muhammad Bery , Kholik Rohmad Abdul
Published: December 2021

Gerakan 3M merupakan gerakan yang dicanangkan pemerintah dalam upaya memutus penyebaran Covid-19 dengan menerapkan protokol kesehatan. Pengabdian Pada Masayarakat yang dilaksanakan di kelurahan Talang Ubi Selatan, kabupaten PALI ini merupakan salah satu bentuk kegiatan kepedulian civitas akademika Universitas PGRI Palembang dalam membantu pemerintah mensosialisasikan gerakan 3M. Dari kegiatan yang dilaksanakan yaitu penyuluhan bahaya covid-19, penyediaan sarana mencuci tangan yang disertai edukasi cara mencuci terutama bagi anak-anak yang belajar mengaji di TPA, serta sosialisasi dan pembagian masker kepada masyarakat umum di seputar kelurahan Talang Ubi Selatan dapat berjalan dengan lancar. Dalam situasi dan kondisi saat ini, kesadaran seluruh masyarakat untuk patuh dan taat dalam menjalankan protokol kesehatan memiliki peranan yang signifikan dalam upaya memutus penyebaran COVID-19
UPAYA MENINGKATKAN MINAT DAN HASIL BELAJAR IPA MENGGUNAKAN MODEL THINK PAIR SHARE SISWA KELAS III SD NEGERI 18 LUBUKLINGGAU
Authors: Yurnalis Yurnalis
Published: December 2021

This study aims to increase the interest and learning outcomes of third grade science students at SD Negeri 18 Lubuklinggau by using the Think Pair Share learning model. This research is a classroom action research (Action Research) using the Think Pair Share learning model. Based on the results of the study through the Think Pair Share learning model in class III at SD Negeri 18 Lubuklinggau can increase student interest and learning outcomes. Increased interest in learning in the first cycle of the first meeting by 62%, in the second cycle by 70% and in the third cycle 88%. To increase student learning outcomes in the first cycle of the first meeting by 62%, in the second cycle by 70% and in the third cycle 88%. Similar to student interest in learning, student learning outcomes after participating in learning with the Think Pair Share model also increased. This is evidenced by the percentage of students who achieved the KKM score in the first cycle of 20% increased to 60% in the second cycle. Furthermore, it still increased to 80% in the third cycle. This means that the number of students who achieve the KKM score (70) has exceeded the established success criteria of 75%.
Association of Histopathological Parameters and Axillary Lymphnode Metastasis in Primary Breast Carcinoma
Authors: Purushotham Manjula K , Venkatesh Pradeep Mitra
Published: December 2021

Introduction: The most common malignancy worldwide among females is breast carcinoma and the second most common malignancy in India, next to cervical cancer. A wide range of potential prognostic features have been studied in breast cancer and are mainly divided into two groups i.e. Histopathological and Molecular. The histological features are cost-effective and provide reliable diagnostic and prognostic information in these tumors. Axillary Lymph node status is one of the most important prognostic factors and greatly affects the morbidity and mortality of the patient. Materials and Methods: All breast cancer specimens received in the Department of Pathology over a period of five years. The following histopathological parameters were carefully studied like Tumor size, Histological type, Grade, Presence of necrosis, Inflammatory cell infiltrate, Lymphatic invasion, Blood vessel invasion, Perineural invasion, and other Stromal changes were studied in detail, and association of these histopathological parameters with axillary lymph node metastasis were analyzed. Results: A total of 100 cases were studied, and most of the patients were over the age of 50. The maximum number of cases was in the T2 stage (55%). Infiltrating ductal carcinoma (88%) was the most common type of tumor encountered in the study. The majority of the cases were Grade I tumors. Skin Invasion was seen in 14% and Lymphovascular Invasion was seen in 17% of cases respectively. There was a statistically significant association between the size of the tumor, T stage, Grade of the tumor, necrosis, and inflammatory infiltrate on further analysis. Conclusion: There was a statistically significant correlation between Tumor size, pathological T stage, Grade of the tumor, Necrosis and inflammatory infiltrate with axillary Lymph node metastasis in the present study. Increased tumor size, T stage, higher grade, presence of necrosis and low inflammatory infiltrate are associated with increased axillary Lymph node metastasis.
Acute Promyelocytic Leukemia: Simplifying Treatment in a Resource Poor Setting
Authors: Bhise Rohan , Ahmed Imtiaz , Imtiaz Sapna
Published: December 2021

Introduction: Acute promyelocytic leukemia (APL) is a distinct leukemia which can be treated with differentiating agents alone.Treatment without chemotherapy decreases the cost of treatment and the need for supportive care. Here we present analysis of APL patients treated with arsenic trioxide (ATO)-all trans retinoic acid (ATRA) without chemotherapy in our hospital.Patients and Methods: Forty three patients with newly diagnosed APL were treated with arsenic trioxide(ATO ) and All trans retinoic acid (ATRA) during induction treatment. For consolidation ATRA 45 mg /m2 for two weeks every four weeks was administered for twenty eight weeks. ATO was administered for four cycles, with a cycle length of eight weeks. The drug was administered at 0.15 mg/kg/d for five days per week for four weeks during each cycle.Patients were followed up with once in three month hemogram and once in six month reverse-transcriptase polymerase chain reaction (RT-PCR) for two years and yearly thereafter. Results: The morphologic complete remission (CR) rate was 86.04%.The most common cause of remission failure was early death due to bleeding. None of the low risk patients died during induction therapy. The most important prognostic factor for early mortality was a high white blood cell (WBC) count at presentation. The median overall survival (OS) has not been reached.The two year OS was 83.4% and the three year OS was 74.8%.The estimated five year survival was 74.8%. At a median follow up of 42.6 months the estimated five year survival in the low-intermediate risk group was 93.3% and 59.1% in the high risk group Conclusion: ATO –ATRA can be considered as a treatment option for frontline treatment of all risk APL patients in resource poor settings.The results can be better with better supportive care to prevent early mortality and by salvaging patients who relapse.
Spinal Accessory Nerve Duplication – A Rare Anatomical Consternation During Neck Dissectio
Authors: Jindal Rohit , Lakhera Kamal Kishor , Patel Pinakin , Singh Suresh , Gothwal Ravinder Singh , Sharma Raj Govind , Sharma Krishan Gopal
Published: December 2021

Prevention of the spinal accessory nerve (SAN) is an indispensable aspect of the functional neck dissection surgery to avoid highly disabling shoulder syndrome postoperatively. This requires comprehensive knowledge of the anatomy of SAN and its variations. Rare anatomical variations like SAN duplication can result in an inadvertant injury to the SAN. We report a case of duplication of SAN, which was encountered while doing a functional neck dissection surgery for oral squamous cell carcinoma. No iatrogenic injury occurred during the surgery and neither there was any SAN dysfunction post-operatively. Meticulous dissection and consistent identification of SAN, along with vast anatomical knowledge is the key to the preservation of the nerve during the surgery. This report aims to broaden our anatomical knowledge of SAN and also discuss the clinical implications and literature pertaining to the duplication of SAN.
Woman-Nature affinity in Desai’s Where Shall We Go This Summer: An Ecofeminist Analysis
Authors: Nawaz Arshad , Iftikhar Nimra , Maqbool Ruqayya
Published: December 2021

This research paper focuses on the images extracted from natural phenomena in Anita Desai's WhereShall We Go This Summer? (1982), to illustrate the pros and cons of patriarchal society'smarginalization and alienation of women in today's world. The article exposes the deep hiddenmeanings of natural imagery through a feministic sensibility. Desai uses natural and animal elementsto create a metaphoric picture of an archetypal feminine figure that works on two levels at the sametime. At a primary level, this technique of inserting natural images at various points throughout thenovel aims to heighten the magnitude and intensity of the mental and spiritual agony of a victimizedwoman who faces domestic violence, male oppression, and female suppression while on a secondarylevel, the role of these images helps the women in the catharsis of that pain, distress, and anguish whichis the result of the rejection of her husband and society as a whole. Karen Warren’s theory ofEcofeminism which regards both women and nature as oppressed objects, is applied for the purpose ofresearch methodology. This research aims to overturn oppressive patriarchal practices by bringingwomen and ecology from the margins to the forefront
ANALISIS KELAYAKAN USAHA TAPE SINGKONG (Manihot esculenta Crantz) SKALA RUMAH TANGGA DI KELURAHAN KANDRI KECAMATAN GUNUNGPATI KOTA SEMARANG
Authors: Setianingrum Hanis Rahma , Sasongko Lutfi Aris , Widiyani Aniya , Hastuti Dewi
Published: December 2021

Penelitian ini dilakukan pada usaha tape singkong (Manihot esculenta Crantz) di Kelurahan Kandri Kecamatan Gunungpati Kota Semarang. Tujuan penelitian ini untuk mengetahui tingkat biaya, penerimaaan, pendapatan, Break Even Point (BEP) dan kelayakan usaha berdasarkan Revenue Cost Ratio (R/C). Metode dasar penelitian metode deskriptif, penentuan responden berdasarkan metode sampel jenuh atau sensus. Responden merupakan pengusaha tape singkong skala rumah tangga sebanyak 20 orang. Pengumpulan data primer dilakukan dengan wawancara dan observasi secara langsung. Metode analisis data menggunakan analisis biaya, penerimaan, pendapatan, BEP dan R/C. Hasil analisis didapatkan untuk satu periode produksi dengan bahan baku sebanyak 22Kg dapat menghasilkan tape singkong sebanyak 16Kg. Biaya tetap yang dikeluarkan sebesar Rp.1.414,00 dan biaya variabel sebesar Rp.99.045,00 dengan biaya total sebesar Rp.100.459,00. Harga jual tape singkong Rp.10.000,00 per Kg menghasilkan penerimaan sebesar Rp.160.000,00 dan pendapatan sebesar Rp.59.541,00. Nilai BEP unit diperoleh sebanyak 11Kg per satu periode produksi dengan nilai BEP harga sebesar Rp.6.279,00. Usaha tape singkong memiliki nilai (R/C) sebesar 1,59. Nilai R/C >1 maka usaha layak diusahakan. Teknik pengupasan yang digunakan menghasilkan nilai rendemen yang berbeda. Bahan bakar yang digunakan akan menghasilkan output yang berbeda. Pengusaha dapat menggunakan teknik pengupasan dan bahan bakar dengan nilai BEP rendah dan R/C paling tinggi.
An ethnic ethnographic review: The kinship system of the Dayak Ribun tribe in West Kalimantan
Authors: Arkanudin Arkanudin , Rupita Rupita , Batuallo Ignasia Debbye
Published: December 2021

This research aims to explore the kinship system of the Dayak Ribun tribe in West Kalimantan. It uses the kinship system tree to visualize the relationship roots. This effort is also based on the refinement of the tree that has existed in the past. Moreover, the method used is an ethnographic approach, where data collection is carried out explicitly using observation, in-depth interviews, and live-in. Ethnic ethnography is gathering a variety of information from its source. According to the results, the kinship system in the Dayak Ribun community is bilateral, that is, relations through two family lineages, both sides of the mother or wife and father or husband. The principle of heredity is bilateral, where the responsibilities of husband and wife are the same in the family, both in children's education and in controlling the family economy. The marriage of a family member who is still a descendant from both the father and the mother is strictly prohibited, which is only allowed to marry between cousins ​​three times. In the distribution of inheritance, there is no difference between sons and daughters. Still, there are differences in some instances, especially for those who remain with their parents. They will get a higher share because they are responsible for their parents' old age until they die.
Uric Acid Levels in Type 2 Diabetes Mellitus Patients
Authors: Ramadhanti Linda , Purlinda Devi Etivia
Published: December 2021

Type 2 diabetes mellitus accounts for about 90% of all diabetes cases worldwide. Type 2 DM is caused by the body's inability to respond well to insulin or called insulin resistance. Insulin resistance causes hyperglycemia and hyperinsulinemia which results in decreased uric acid excretion function in the kidney tubules, so that there will be an increase in uric acid in the blood or hyperuricemia. Type of research including descriptive with cross sectional approach. The examination was carried out at Dr. Adhyatma, MPH. The research respondents were 24 people, uric acid levels were examined with a TMS 50i Superior device. The data obtained is processed and presented in the form of diagrams and percentages. Type 2 DM respondents numbered 24 people. The highest hyperuricemia is based on the characteristics of the respondents, those are above 55 years old (25%), female sex (25%), high blood pressure (25%), and exercise activity 1x / day (21%). Of the 24 respondents, 14 people (58.3%) had normal uric acid levels and 10 people (41.6%) had hyperuricemia, with an average female uric acid value of 5.54 mg / dL and men of 6,48 mg / dL.
Incompatible Results on Matched Cross Test Examination
Authors: Aljannah Nur Fajrin , Sri Supadmi Francisca Romana
Published: December 2021

Compatibility testing before blood transfusion is very crucial. This procedure to prevent transfusion reactions due to blood group incompatibility or irregular antibodies. Cross-matching to ensure that the blood safe for the recipient. There are two results in the cross-matching, namely compatible and incompatible. This study aims to determine the inappropriate results of cross-matching at Blood Transfusion Service of the Indonesian Red Cross, Kulon Progo Regency. This study used a quantitative descriptive research design with a retrospective approach. The samples used in this study were 78 incompatible samples in Blood Transfusion Service of the Indonesian Red Cross, Kulon Progo Regency. The sampling technique used was the total population. Methods of data analysis using descriptive analysis. The results show incompatibilities of most compatible cross tests found in minor and auto control (96.1%) with male gender frequency (35.9%) and women (64.1%). The most blood type that has incompatibilities is blood type O (43.3%). The most Diagnosis is anemia (76.9%), and the most components are PRC (88.4%). The most incompatible types are minor and auto control and the most commonly encountered in women, O blood type, anemia, and components of PRC.
Predicting malignancy in thyroid nodules with benign cytology results: The role of Conventional Ultrasound, Shear Wave Elastography and BRAF V600E
Authors: Zhang Ying , Lu Feng , Shi Hui , Guo Le-Hang , Wei Qing , Xu Hui-Xiong , Zhang Yi-Feng
Published: December 2021

BACKGROUND: Ultrasound-guided fine-needle aspiration (US-FNA) is the most accurate method for preoperative diagnosis of thyroid nodules, but how to deal with false negative results? OBJECTIVE: This study aimed to find preoperative diagnosis methods including Conventional Ultrasound (CUS), Shear Wave Elastography (SWE) and BRAF V600E testing to differentiate false negative nodules. METHODS: Forty-nine nodules in 49 patients with benign FNA results and pathological diagnoses were included. CUS and SWE features were evaluated. BRAF V600E analysis was performed after FNA. Diagnostic performances of three methods were analyzed in predicting malignancy in benign FNA results. RESULTS: Twenty-seven of 49 nodules were malignant, and 22 nodules were benign. Hypoechogenicity, taller-than-wider, irregular boundary, microcalcification, SWE max, SWE mean and BRAF V600E mutation were risk factors for malignancy. All 7 malignant nodules with BRAF V600E mutations and 18 of 20 malignant nodules without BRAF V600E mutations have two or more suspicious CUS features. Six of 7 malignant nodules with BRAF V600E mutations and 16 of 20 malignant nodules without BRAF V600E mutations had SWE mean value greater than the cut-off value. CONCLUSIONS: CUS, SWE and BRAF V600E were diagnostic tools for malignancy in FNA benign nodules. Further clinical decisions should be considered for nodules with two or more suspicious CUS features and SWE parameters greater than cut-off values whether BRAF V600E is mutational or not.
Plasma EFEMP1 Is Associated with Brain Aging and Dementia: The Framingham Heart Study
Authors: McGrath Emer R. , Himali Jayandra J. , Levy Daniel , Yang Qiong , DeCarli Charles S. , Courchesne Paul , Satizabal Claudia L. , Finney Rebecca , Vasan Ramachandran S. , Beiser Alexa S. , Seshadri Sudha
Published: December 2021

Background:

Epidermal growth factor containing fibulin extracellular matrix protein-1 (EFEMP1) has been associated with increased white matter hyperintensities (WMH) burden and disorders of premature aging and may have a shared pathophysiological role in the development of WMH and dementia.

Objective:

To determine the association between plasma EFEMP1 levels and MRI markers of vascular brain injury and incident all-cause and Alzheimer’s disease (AD) dementia.

Methods:

We measured plasma EFEMP1 levels in 1597 [53% women, mean age 68.7 (SD 5.7) years] dementia-free Framingham Offspring cohort participants between 1998–2001 and subsequently followed them for incident dementia. Secondary outcomes included stroke, structural MRI brain measures and neurocognitive test performance.

Results:

During a median 11.8 [Q1, Q3 : 7.1, 13.3] year follow-up, 131 participants developed dementia. The highest quintile of plasma EFEMP1, compared to the bottom four quintiles, was associated with an increased risk of time to incident all-cause dementia (HR 1.77, 95% CI 1.18–2.64) and AD dementia (HR 1.76, 95% CI 1.11–2.81) but not with markers of vascular brain injury (WMH, covert brain infarcts or stroke). Higher circulating EFEMP1 concentrations were also cross-sectionally associated with lower total brain (β±SE, –0.28±0.11, p = 0.01) and hippocampal volumes (–0.006±0.003, p = 0.04) and impaired abstract reasoning (Similarities test, –0.18±0.08, p = 0.018 per standard deviation increment in EFEMP1).

Conclusion:

Elevated circulating EFEMP1 is associated with an increased risk of all-cause and AD dementia, smaller hippocampal and total brain volumes, and poorer cognitive performance. EFEMP1 may play an important biological role in the development of AD dementia. Further studies to validate these findings are warranted.
Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series
Authors: Dhaynaut Maeva , Sprugnoli Giulia , Cappon Davide , Macone Joanna , Sanchez Justin S. , Normandin Marc D. , Guehl Nicolas J. , Koch Giacomo , Paciorek Rachel , Connor Ann , Press Daniel , Johnson Keith , Pascual-Leone Alvaro , El Fakhri Georges , Santarnecchi Emiliano
Published: December 2021

Background:

Alzheimer’s disease (AD) is characterized by diffuse amyloid-β (Aβ) and phosphorylated Tau (p-Tau) aggregates as well as neuroinflammation. Exogenously-induced 40 Hz gamma oscillations have been showing to reduce Aβ and p-Tau deposition presumably via microglia activation in AD mouse models.

Objective:

We aimed to translate preclinical data on gamma-induction in AD patients by means of transcranial alternating current stimulation (tACS).

Methods:

Four participants with mild to moderate AD received 1 h of daily 40 Hz (gamma) tACS for 4 weeks (Monday to Friday) targeting the bitemporal lobes (20 h treatment duration). Participant underwent Aβ, p-Tau, and microglia PET imaging with [11C]-PiB, [18F]-FTP, and [11C]-PBR28 respectively, before and after the intervention along with electrophysiological assessment.

Results:

No adverse events were reported, and an increase in gamma spectral power on EEG was observed after the treatment. [18F]-FTP PET revealed a significant decrease over 2% of p-Tau burden in 3/4 patients following the tACS treatment, primarily involving the temporal lobe regions targeted by tACS and especially mesial regions (e.g., entorhinal cortex). The amount of intracerebral Aβ as measured by [11C]-PiB was not significantly influenced by tACS, whereas 1/4 reported a significant decrease of microglia activation as measured by [11C]-PBR28.

Conclusion:

tACS seems to represent a safe and feasible option for gamma induction in AD patients, with preliminary evidence of a possible effect on protein clearance partially mimicking what is observed in animal models. Longer interventions and placebo control conditions are needed to fully evaluate the potential for tACS to slow disease progression.
Neuropsychiatric Symptoms in Patients with Neurocognitive Disorder and Their Performance Between Mild and Major Stages
Authors: Botero-Rodríguez Felipe , Córdoba Sastoque Ana Melisa , Santacruz Escudero José Manuel , Santamaría-García Hernando
Published: December 2021

Background:

The neuropsychiatric symptoms (NPS) in patients with neurocognitive disorders (NCD) increases the risk of exhibiting significant cognitive and functional decline. However, to the best of our knowledge, few studies have evaluated to what extent the presence of chronic and early NPS impacts cognition and functionality in patients with minor or major stages of NCD.

Objective:

We aimed to assess the interplay between early and chronic NPS and cognitive and functional presentation of patients with mild and major forms of NCD.

Methods:

We used two NPS tools tracking early and late NPS and assessed to what extent they determine cognitive and functional outcomes in patients with mild and major forms of NCD.

Results:

We found an inverse relationship between the presence of NPS, as measured by the Neuropsychiatric Inventory and Mild Behavioral Impairment Checklist (MBI-C), and cognitive and functional variables in major forms of NCD. In contrast, the minor stage of NCD was associated with increased MBI-C scores.

Conclusion:

Our results revealed that NPS are associated with cognitive and functional outcomes in mild and chronic forms of NCD. Crucially our results suggest that NPS could be considered as a pathological marker of the clinical course of dementia. Additionally, our study calls to study early and late forms of NPS as both impact cognition and functionality of NCD.
GRK5 Deficiency Causes Mild Cognitive Impairment due to Alzheimer’s Disease
Authors: Suo William Z.
Published: December 2021

Prevention of Alzheimer’s disease (AD) is a high priority mission while searching for a disease modifying therapy for AD, a devastating major public health crisis. Clinical observations have identified a prodromal stage of AD for which the patients have mild cognitive impairment (MCI) though do not yet meet AD diagnostic criteria. As an identifiable transitional stage before the onset of AD, MCI should become the high priority target for AD prevention, assuming successful prevention of MCI and/or its conversion to AD also prevents the subsequent AD. By pulling this string, one demonstrated cause of amnestic MCI appears to be the deficiency of G protein-coupled receptor-5 (GRK5). The most compelling evidence is that GRK5 knockout (GRK5KO) mice naturally develop into aMCI during aging. Moreover, GRK5 deficiency was reported to occur during prodromal stage of AD in CRND8 transgenic mice. When a GRK5KO mouse was crossbred with Tg2576 Swedish amyloid precursor protein transgenic mouse, the resulted double transgenic GAP mice displayed exaggerated behavioral and pathological changes across the spectrum of AD pathogenesis. Therefore, the GRK5 deficiency possesses unique features and advantage to serve as a prophylactic therapeutic target for MCI due to AD.
Alzheimer’s Disease: A Decreased Cerebral Blood Flow to Critical Intraneuronal Elements Is the Cause
Authors: Goldsmith Harry S.
Published: December 2021

Normally, an adequate cerebral blood flow arrives at individual cerebral neurons in which the blood flow augments activity of intraneuronal mitochondria, which is the source of intraneuronal ATP, the energy source of cerebral neurons. With a decrease in cerebral blood flow that can occur as a function of normal aging phenomena, less blood results in decreased mitochondria, decreased ATP, and a decrease in neuronal activity, which can eventually lead to Alzheimer’s disease. It has been found that placement of the omentum directly on an Alzheimer’s disease brain can lead to improved cognitive function.
A non-continuous soft mapping that preserves some structural soft sets
Authors: Ameen Zanyar A.
Published: December 2021

As everyday problems contain a lot of data and ambiguity, it has become necessary to develop new mathematical approaches to address them and soft set theory is the best tool to deal with such problems. Hence, in this article, we introduce a non-continuous mapping in soft settings called soft U -continuous. We mainly focus on studying soft U -continuity and its connection to soft continuity. We further show that soft U -continuity preserves soft compact sets and soft connected sets. The later sets have various applications in computing science and decision making theory. In the end, we show that if each soft U -continuous mapping f from a soft space X into a soft T0-space Y is soft continuous, then Y is soft T1.
Investigating the efficiency of the Asian handicap football betting market with ratings and Bayesian networks
Authors: Constantinou Anthony C.
Published: December 2021

Despite the massive popularity of the Asian Handicap (AH) football (soccer) betting market, its efficiency has not been adequately studied by the relevant literature. This paper combines rating systems with Bayesian networks and presents the first published model specifically developed for prediction and assessment of the efficiency of the AH betting market. The results are based on 13 English Premier League seasons and are compared to the traditional market, where the bets are for win, lose or draw. Different betting situations have been examined including a) both average and maximum (best available) market odds, b) all possible betting decision thresholds between predicted and published odds, c) optimisations for both return-on-investment and profit, and d) simple stake adjustments to investigate how the variance of returns changes when targeting equivalent profit in both traditional and AH markets. While the AH market is found to share the inefficiencies of the traditional market, the findings reveal both interesting differences as well as similarities between the two.
Popularization of M. Fedoriv’s creativity by modern leaders of the music culture diaspora in Canada
Authors: Yatsiv Iryna
Published: December 2021

The purpose of the article is an esthetic and cultural analysis of art by M. Fedoriv in the projection of performing practice the contemporary figures of musical culture in the diaspora. Methodology. To achieve the set objective was used comparative-historical, culturological, axiological theoretical and methodological approaches, also biographical and art history methods of scientific knowledge, which directed on the disclosure of the immanent features of investigated products of the creative activity of the personalities in this scientific research; determining the significance of M. Fedoriv’s in the context of the development of Ukrainian musical culture of the 20th century. The scientific novelty of the work consists in applying cultural products of the music industry (gramophone record, CDs), as elements in the source base of research in methodology comparative analysis performance-conducting interpretation of the musical heritage of the composer in the context into the professional activity of Canadian musicians. Conclusions. M. Fedoriv is a representative of the highly professional musicians from the diaspora, which multi-vector activity is marked by the upturn of the basic form of cultural identification. In order to convey the historical authenticity of the national musical tradition of liturgical singing, he researched and published church-religious tunes of the practice of worship in Ukraine, which stoped the total simplification in the performance of canonical chants in the churches of the diaspora. Reaching our time, the popularization of M. Fedoriv's work was possible thanks to the performance and production work of M. Maksymiv and R. Hurko. Thus, in except to the rotation of the digitized album «Jerusalem Matins» by M. Fedoriv on the air of foreign radio broadcasters: CBC (Canada), BBC Radio 3 (Great Britain), M. Maksimiv succeeded to reissue the CD recording of the Liturgy twice and distribute it on social network platforms. However, the precedent of reviving the process of integrating the composer's heritage into the modern media space is the activity of R. Hurko. However, the precedent of reviving the process of integrating the composer's heritage into the modern media space is the activity of R. Hurko. Under his record label CARO Productions, the artist places the audio content produced by him, the same Liturgy on Youtube, and in the form of a tracklist of a music album on commercial services (Apple Music, Deezer, Spotify). Thus, the planes of the personal activity of M. Maksymov and R. Gurko became an example of representation of dominant features of the nation's cultural genome between different generations of Ukrainians, and M. Fedoriv's work is available to its target audience beyond temporal and any territorial borders.
PENGARUH DANA PIHAK KETIGA (DPK) DAN MODAL SENDIRI TERHADAP PEMBIAYAAN MURABAHAH PADA BANK UMUM SYARIAH PERIODE 2016-2019
Authors: Sari Liana , Feb Wirman
Published: December 2021

Penelitian ini bertujuan untuk  dapat mengetahui apakah terdapat pengaruh dalam(DPK) Dana Pihak Ketiga, dan Modal Sendiri terhadap Pembiayaan Murabahah. Penelitian ini dilakukan terhadap Bank  Umum  Syariah  tahun  2016-2019.  Penelitian  ini  merupakan penelitian  yang  termasuk  dalam kuantitatif dengan alat untuk mengolah data menggunakan SPSS 25.0. Alat ukur untuk menganalisis yang digunakan adalah analisis regresi linear berganda. Uji hipotesis yang digunakana adalah Uji Parsial (Uji T) dan Uji Simultan (Uji F), dan djuga dilakukan Uji asumsi klasik yang meliputi uji normalitas, uji multikolinieritas, uji autokorelasi dan uji heteroskedastisitas. Hasil penelitian menunjukkan bahwa Dana Pihak Ketiga berpengaruh positif secara signifikan terhadap Pembiayaan Murabahah, variabel Modal Sendiri berpengaruh positif secara tidak signifikan terhadap Pembiayaan Murabahah. Dan hasil pengujian bahwa  Dana Pihak Ketiga dan  Modal Sendiri secara  simultan berpengaruh terhadap Pembiayaan Murabahah.

 

Kata kunci : Dana Pihak Ketiga; Modal Sendiri; Pembiayaan Murabahah
Historia de CITES en España: 35 años de control del comercio internacional de especies amenazadas
Authors: Arrieta Casas Ana María , Frechilla Flórez Lucía , Galilea Jiménez Antonio , Núñez Román Mercedes , Sanmamed Aranburu Mar , Tortajada Perrote Rosa
Published: December 2021

Durante los años sesenta, debido al excesivo uso comercial de los recursos naturales, muchos Gobiernos, y también la sociedad, empiezan a tomar conciencia de la necesidad de adoptar medidas que permitan equilibrar el uso sostenible de los recursos naturales y la conservación de los mismos. Ello llevó a que ventiún países firmaran en el año 1973 el Convenio sobre el Comercio Internacional de Especies Amenazadas de Fauna y Flora Silvestres (CITES). Este convenio ha conseguido convertirse en un exitoso instrumento comercial al servicio de la conservación y el uso sostenible de las especies, capaz de combinar de manera eficaz la relación entre comercio y medioambiente. A día de hoy cuenta con la amplia participación de 184 países, habiendo sido España el 89.º  en adherirse a él en el año 1986. Desde entonces, la Secretaría de Estado de Comercio ha estado al frente de la aplicación de este convenio como autoridad administrativa principal del mismo realizando una encomiable labor ampliamente reconocida a nivel internacional.
Assessing the Level of Walkability for Women Using GIS and Location-based Open Data: The Case of New York City
Authors: Gorrini Andrea , Presicce Dante , Choubassi Rawad , Sener Ipek Nese
Published: December 2021

Utilizing GIS and location-based open data, this study examined the level of walkability for women in New York City. As highlighted through a thematic literature review, women experience the city differently than men, since they are more concerned with security issues related to aggression and harassment, as a major inhibitor of mobility in public spaces especially at nighttime. The analysis focused on the level of usefulness, comfort, safety, security, and attractiveness of the city. The results of the proposed Walkability for Women Index helped to identify and characterize a short list of suitable urban areas where to prioritize interventions.
A MAC Layer Protocol For Smart Indoor Inventory Management System
Authors: Li Xiaofeng
Published: December 2021

The indoor inventory system is gaining more research attention and commercial value with
the development of IoT. In this thesis, we presented the design of a MAC protocol that allows
synchronized transmission of location and sensing data in a wireless positioning and sensor
network for an indoor inventory system. The network supports real-life industrial applications and
provides a highly specific positioning method.
In the network, mobile sensing tags are connected to smart readers that performs localization
of tags and gathers sensing data from the tags. The readers are connected to the back-end cloud.
The proposed MAC serves multiple classes of mobile tags with different priorities and latency
requirements. These tags transmit critical, position and sensing data with different QoS
requirements. The proposed MAC is a hybrid MAC that offers contention-based period for tag
discovery and scheduled period for the transmission of sensing data with guaranteed latency. We
conducted simulation to evaluate the performance of different methods of discovery process and
their impact on latency assurance. We also developed a queuing model to analyze the relationship
between parameters, acquiring parameters through experiment, and calculation of boundary
values.

Simulation using MatLabTM software suggests that the joining period in design can increase
the transmission success rate of high priority messages at the cost of a slight increment in the delay
of low priority messages. Preliminary analysis suggests that by adaptively allocating the channel
resources of the network to three types of tags, service efficiency can be improved. This result also
guides the direction for further improvement.

We explored the performance of two options considered currently, which is selecting the
discovery process according to modulo result of unique 16-bit tag ID and random select of an
available discovery process. In the current environment where each tag does not have any
information about other tags inside the network, the two methods have the same effect on
avoiding collisions that could happen in a single discovery cycle.

The proposed MAC layer protocol can provide the best service when the available discovery
process in the discovery cycle is for initialization and resetting. For an emergency, the joining period
designs can still ensure a success rate for critical messages to be over 90%. Hence, the simulation
results indicate the joining period method is able to improve MAC-layer performance.
Adaptive Data-Transition Decision Feedback Equalizers For High-Speed Serial Links
Authors: Li Yue
Published: December 2021

This dissertation investigates adaptive decision feedback equalizers for high-speed
serial data links.
An adaptive data-transition decision feedback equalizer (DT-DFE) was developed. The DT-DFE boosts the eye-opening of the high-frequency components
of data without attenuating their low-frequency counterparts. Reference voltages
were obtained by transmitting consecutive 1s and 0s and measuring the output
of the continuous-time linear equalizer using a pair of successive approximation
register analog-to-digital converters in a training phase. It uses loop unrolling
to detect data transitions, activate tap-tuning, launch DFE, and combat timing
constraints. The performance of the DT-DFE and its advantages over commonly
used data-state DFE were validated using the schematic-level simulation results
of 5 Gbps backplane links.

A new adaptive DT-DFE with edge-emphasis (EE) taps and raised references
was developed. Loop-unrolling was further developed for DT-DFE with EE-taps.
The reference voltages were raised beyond that set by the low-frequency components of data to increase vertical eye-opening. Clock and data recovery was performed using 4x oversampling. The DT-DFE was validated using the schematiclevel simulation results of 10 Gbps backplane links.

A pre-skewed bi-directional gated delay line (BDGDL) bang-bang frequency
difference-to-digital converter and a BDGDL integrating frequency difference-todigital converter (iFDDC) were proposed for clock and data recovery. Both frequency difference detectors feature all-digital realization, low power consumption,
and high-speed operation. The built-in integration of iFDDC results in a zero
static frequency error and the first-order noise-shaping of the quantization errors
of the BDGDL and digitally-controlled oscillators. Their effectiveness was validated using schematic-level simulation results of 5-GHz frequency-locked loops.

All systems validating the proposed adaptive DFE and frequency-difference
detectors were designed in TSMC’s 65 nm CMOS technology and analyzed using
Spectre from Cadence Design Systems.
Energy-Efficient Hybrid Unicore Architecture In Future Embedded Chip-Multiprocessor
Authors: Hadeed Akram
Published: December 2021

Recently, technology scaling has enabled the placement of an increasing number of cores, in the form of
chip-multiprocessors (CMPs) on a chip and continually shrinking transistor sizes to improve performance.
In this context, power consumption has become the main constraint in designing CMPs. As a result, uncore
components power consumption taking increasing portion from the on-chip power budget; therefore,
designing power management techniques, particularly memory and network-on-chip (NoC) systems, has
become an important issue to solve. Consequently, a considerable attention has been directed toward power
management based on CMPs components, particularly shared caches and uncore interconnected structures, to
overcome the challenges of limited chip power budget.
This work targets to design an energy-efficient uncore architecture by using heterogeneity in components
(cache cells) and operational parameters (Voltage/Frequency). In order to ensure the minimum impact on the
system performance, a run-time approach is investigated to assess the proposed method. An architecture is
proposed where the cache layer contains the heterogenous cache banks in all placed in one frequency voltage
domain. Average memory access time (AMAT) was selected as a network monitor to monitor the performance
on the run-time. The appropriate size and type of the last level cache (LLC) and Voltage/Frequency for the uncore
domain is adjusted according to the calculated AMAT which indicates the system demand from the uncore.

The proposed hybrid architecture was implemented, investigated and compared with the a baseline model
where only SRAM banks were used in the last level cache. Experimental results on the Princeton Application
Repository for Shared-Memory Computers (PARSEC) benchmark suit,show that the proposed architecture yields
up to a 40% reduction in overall chip energy-delay product with a marginal performance degradation in average
of -1.2% below the baseline one. The best energy saving was 55% and the worse degradation was only 15%.
An Isolated Soft-Switched DC-DC Converter For Interconnection Of Medium- And Low-Voltage DC Grids
Authors: Saeedifard Hossein
Published: December 2021

As the electric power grid increasingly hosts energy storage devices, renewable energy resources, plug-in hybrid and electric vehicles, and data centers, it is expected to benefit in the future
from a multi-layer DC structure meshed within its legacy AC architecture. As such a multi-layer
grid structure evolves, interconnection of DC grids with different voltage levels will become necessary. For such interconnections and for power-flow control, efficient isolated DC-DC converters
are a key enabling technology. This thesis thus presents the results of an in-depth investigation into
the operation, modulation, control, and performance assessment of a particular DC-DC converter
configuration. The proposed DC-DC converter, which is based upon a hybrid combination of the
conventional dual-active-bridge topology and the modular multi-level converter (MMC) configuration, is a potential candidate topology for interconnection of medium- and low-voltage DC grids.
The thesis first introduces the circuit topology and presents the basics of operation and governing steady-state equations for the converter. Then, based on the developed mathematical model,
it identifies a suitable modulation strategy for the converter bridges and submodules, as well as
strategies for the regulation of the MMC submodule capacitor voltages and soft switching of the
constituent semiconductor devices. The proposed converter topology offers significant benefits
including galvanic isolation, utilization of the transformer’s leakage inductance, soft switching for
high-frequency operation, and bidirectional power flow capability. The validity of the mathematical model, effectiveness of the proposed modulation and control strategies, and the realization
of soft switching are verified through off-line simulation of a detailed circuit model as well as
experiments conducted on a 1-kW experimental setup.