bluuebunny/crossref_metadata_2025 huggingface dataset:
Anatomia palpatória como estratégia de interação entre os conteúdos teóricos da Anatomia do Sistema Locomotor e a prática clínica no primeiro período do curso de medicina
Authors: Leite Izabel Feitosa da Mata , Silva Gabrielle Grijó e , Cupertino Filho Jorge Reis , Corrêa Vivian de Oliveira Sousa
Published: November 2022

This study presents an analysis of the implementation of Palpatory Anatomy as a methodology of interaction between the theoretical subjects of the anatomy of the musculoskeletal system and clinical practice in the context of Human Anatomy teaching, from the perspectives of students from the first period of the Medical School at the Federal University of Rio de Janeiro, Macaé Campus (UFRJ-Macaé). Palpatory Anatomy activities were included in the Human Anatomy course and a perception questionnaire was distributed to be answered by the students at the end of the semester. 84.71% of the total number of participants (144 students) agreed that the sessions contributed to learning the subject, and 72.22% reported an increased interest in the topic, results that are in accordance with the 2014 Curriculum Guidelines. On the other hand, there were criticisms on the short time devoted to the activity and the number of sessions. Although the current curricular structure of medicine courses makes it difficult to practice multimodal approaches, the inclusion of Palpatory Anatomy is encouraged as a teaching strategy for Human Anatomy, and as a skill to be developed and practiced throughout medical training, due to its relevance in performance of a good physical examination and clinical reasoning.
THE PROBLEM-SOLVING ANALYSIS IN SOLVING TRIGONOMETRIC PROBLEMS BASED ON BRANSFORD & STEIN STEP OF CAMPERS STUDENTS
Authors: Fortuneladewi Asri -
Published: November 2022

This research aims to describe how the problem-solving ability of campers students in solving trigonometry problems. This study uses the problem-solving theory by Bransford & Stein that consists of five steps, namely identifying problems, defining goals, exploring possible strategies, anticipating results and acting, and looking back and learning. The technique of taking the subject in this study used purposive sampling. The research subjects were five students of IPA vocational high school. The instruments used were tests, interviews, and questionnaires. The results showed that campers students in solving trigonometry problems are pretty good. The students can fulfill four indicators of Bransford & Stein's problem-solving: (1) collect information, (2) define goals, (3) find problem-solving strategies, (4) use the correct arithmetic operations, and can find the result.
Ressourcenaufbauprogramm R.A.P. : Ein manualisiertes Gruppenprogramm zum Aufbau personaler Ressourcen für psychisch erkrankte Menschen
Authors: Küber Lisa
Published: November 2022

Das „Ressourcenaufbauprogramm R.A.P.“ ist ein achtwöchiges Gruppenprogramm, das explizit für die Zielgruppe der chronisch psychisch erkrankten Menschen konzipiert wurde. Ziel des Programms ist der Auf- und Ausbau diverser personaler Ressourcen wie beispielsweise das subjektive Wohlbefinden, das Selbstwertgefühl, die Selbstfürsorge sowie weitere gesundheitsrelevante Parameter. Die Themen der acht Sitzungen gestalten sich wie folgt: 1) Einführung und Ressourcenblick 2) Positive Aktivitäten 3) Genuss im Alltag 4) Dankbarkeit und das Positive 5) Eigene Stärken erkennen und nutzen 6) Wertschätzung üben 7) Hilfsbereitschaft, Mitmenschlichkeit und Freundlichkeit 8) Zusammenfassung und Abschluss
Acoustic Field of an Ultrasound Device for Differential Diagnosis of Human Hearing
Authors: Liashko Dariia Oleksandrivna , Naida Serhii Anatoliiovych
Published: November 2022

In this paper analyzes the relevance and novelty of using a multielement array in an electroacoustic transducer for differential diagnosis of human inner ear coagulation by changing the pulse duration and direction of radiation. Today the clinical applications of ultrasound are numerous and diverse, and ultrasound diagnostics is one of the most rapidly developing methods in medicine. In recent years the effect of focused ultrasound on the human auditory system has been actively studied. The structure of the human inner ear is in the middle of a system of spaces and channels of bony labyrinths. It is known that the most successful way to the auricular labyrinth is the one with the shortest distance and with the least tissue loss.
In order for the width of the scanning ultrasound beam to remain constant throughout the entire length of probing, the mode of dynamic focusing of the ultrasound beam was considered. The ultrasonic beam in the scanners is formed using a linear multielement array with individual element dimensions of several wavelengths by introducing between the electrical signals sent or received from the elements such delays that ensure that the fields are focused at a given point on the beam axis, and additionally by using acoustic lenses. In practice, the problem is solved by successive focusing of the beam at several fixed distances from the working surface.
Calculations of the geometric dimensions and the study of the acoustic field for the cylindrical wave front created by a linear multielement array of piezoelements are performed. Calculations of the acoustic field distribution in depth at varying pulse duration and at changing the angle of deflection from the axis, with the focal distance unchanged.  It is concluded that it is reasonable to use this type of electroacoustic transducer for differential diagnosis of human hearing. From the obtained graphs it was found that an increase in the pulse attenuation coefficient leads to a decrease in the values of the diffraction maximum. It is also shown that the relative amplitude of the diffraction maximum can be reduced by reducing the pulse duration and increasing the number of piezoelectric elements in the working group.   
This type of piezoelectric transducer will allow, by changing the angle, to affect all parts of the cochlea of a person, as it is known that each part of the cochlea is responsible for a certain frequency of perception, pick up a certain duration for safe exposure. And it will also be possible to perform acoustic influence on the cochlea to confirm the functioning of the auditory nerves before cochlear implantation.
Agrobiodiversity dynamics in a French wine-growing region
Authors: Doncieux Antoine , Yobrégat Olivier , Prudham Scott , Caillon Sophie , Renard Delphine
Published: November 2022

Agrobiodiversity is a promising nature-based solution in the pursuit of sustainable agriculture. In wine-growing systems, commercial pressure and varietal regulations have narrowed agrobiodiversity in vineyards despite higher diversity being an important buffer against the effects of climate change. If drivers of grape diversity change are well-understood at national to global scales, little is known about the local, past or anticipated trajectories that drive agrobiodiversity dynamics depending on growers’ cultural values, practices and choices. We combined quantitative agricultural census data and qualitative ethnographic approaches to characterise changes in the diversity of grape varieties from 1960 to 2020 at the communal and vineyard levels in a French wine-growing region, and to decipher the drivers of change. We highlight that vineyards have drastically changed in 60 years, with a decline in planted area and in farm number. We outline that despite a loss of varietal richness across both vineyard and communal scales, varietal richness remains high and evenness have increased across geographic scales in 2020. Ethnographic field observations emphasize that growers account for external drivers (e.g., market changes, regulation and policy, technology, environmental), but also cultural values when they choose which grape varieties to plant. Grape diversity was maintained despite market integration as an insurance to spread production risk, mitigate market volatility and address environmental uncertainties. Securing livelihoods in the midst of market changes has been a major concern for growers over the last six decades and remains so. Despite a pessimistic future vision of the vineyard shared by most growers, the Gaillac region has a cultural heritage that values diversity and that thereby supports adaptation to climate change. We expect that environmental factors may play a more important role in grape selection and planting sites in the future under the influence of climate change and pesticide reduction policies. In order to expand individual initiatives resulting in diversified grape selection, growers need to be better connected with stakeholders at a variety of institutional levels.
Nominata
Authors: De Vitória Faculdade Unida
Published: November 2022

Nominata de avaliadores 2016
AI DE VÓS, AI DE NÓS. O caminho de purificação proposto por Jesus em Lucas 11.37-44
Authors: Solano Rossi Luiz Alexandre , Schietti Mariana
Published: November 2022

Na perícope de Lc 11,37-44 Jesus é convidado por um fariseu para uma refeição e, ao sentar-se à mesa, ele ignora os ritos legais que deveriam ser praticados antes das refeições. Ao percebendo que o fariseu estava espantado, Jesus responde à indignação do mesmo com uma análise sobre a limpeza interior e exterior e logo em seguida profere três ais contra os mesmos. O presente artigo busca demonstrar que a purificação das pessoas não se dá por meio da prática dos ritos religiosos, como era proposto pelo grupo dos fariseus nos tempos de Jesus. Antes, a purificação passa pela prática da justiça, que está ligada a uma disposição interna de cada pessoa.
Fundamentalismo e Adventismo no século XXI: uma leitura da Revista Adventista (2000-2019)
Authors: Campos Breno Martins , Costa Samir Domingues
Published: November 2022

Com base em pesquisa bibliográfica e documental, este artigo contribui com mais um passo na direção de classificar o fundamentalismo protestante no Brasil. Mais do que reconhecer a presença do fundamentalismo na igreja do outro, o que se busca é compreender como a Igreja Adventista do Sétimo Dia se localiza no fundamentalismo ou, por inversão, como reconhece o fundamentalismo em si mesma. Para isso, a quase totalidade das obras de referência (tanto as fontes primárias como as secundárias) foi buscada em documentos e autores adventistas. Como resultado, constata-se que, dentro da mais que centenária controvérsia liberalismo versus fundamentalismo, o adventista tenderia ao fundamentalismo, não fosse ele um termo-conceito carregado de juízo de valor negativo. Entretanto, adventistas reconhecem seu "fundamentalismo" (assim, entre aspas) no que preservam do conservadorismo protestante sobre o estatuto de verdade das Escrituras – mas não na totalidade do espírito e ethos do movimento fundamentalista originário.
O caminho do mundo interior em Teresa de Ávila
Authors: Kirchner Renato , Alves Josué Andrade
Published: November 2022

Considerado o texto mais conhecido de Teresa de Ávila como mestra espiritual, Castelo interior ou moradas pode ser classificado como um guia de viagem. Conforme o título mesmo sugere, o que o distingue como guia é o rumo a ser tomado e empreendido. Teresa descreve aventuras experimentadas numa rota mais surpreendente e misteriosa: pelo caminho do mundo interior. Ela escreve como quem já percorreu tal caminho. Quem parte deseja alcançar o termo para aí permanecer. O movimento torna-se claro na estrutura das sete “moradas” do castelo. O texto apresentado aqui possui o intuito de interpretar as estruturas e formas do caminho ao mundo interior e demonstrar as transformações ocorridas na alma ao ultrapassar cada morada, mediante leitura, análise temática, interpretação e síntese da obra e, na medida em que se fizer necessário, pela utilização de comentadores da obra teresiana. A alma disposta a percorrer tal jornada possui um único objetivo, a saber, adentrar ao próprio interior da alma: um castelo. Por que um castelo? Porque nele mora um Rei e, por intermédio da união mística, no matrimônio espiritual, se estabelece a conexão extrema de vontades entre alma e Deus.
Religião e Prisão desde a Teologia Pública: Uma relação de colaboração, assistência e crítica
Authors: Duarte Lucas Henrique Pereira , Sinner Rudolf von
Published: November 2022

O presente artigo busca investigar as relações entre as prisões e as religiões no Brasil. Com base em pesquisa bibliográfica e reflexão conceitual, desnaturaliza-se as prisões a partir de um olhar histórico, destacando a colaboração material e ideológica teologia católica para a formação das prisões. Apresenta-se também a atuação de grupos e lideranças religiosas no cárcere através do serviço legal de assistência religiosa, dando atenção à diversidade de abordagens, discursos e práticas das religiões cristãs e de matrizes africanas. E, finalmente, propõe-se um olhar crítico ao encarceramento a partir da superação de teologias justificadoras da violência estatal pelo de noções de liberdade, justiça e vida.
A IGREJA CATÓLICA E OS DIREITOS HUMANOS NO BRASIL CONTEMPORÂNEO
Authors: Godoy João Miguel Teixeira , Cianci Rafaella Marcopito
Published: November 2022

O presente artigo trata-se de uma pesquisa de caráter historiográfico e documental. Tem como objetivo investigar o envolvimento da Igreja Católica brasileira na militância pelos Direitos Humanos durante a Ditadura Militar, sobretudo após a promulgação do Ato Institucional nº 5 (1968). Para tanto, serão analisados documentos emitidos pela Conferência Nacional dos Bispos do Brasil, durante as décadas de 1970 e 1980. Com esta pesquisa, espera-se elucidar a atuação da Igreja frente às torturas e violações dos direitos humanos.
ENSINO RELIGIOSO E O DESAFIO DA PRÁTICA CURRICULAR NO MUNICÍPIO DE CARIACICA
Authors: Zagotto Daniela Leal
Published: November 2022

O Ensino Religioso tem em sua trajetória histórica, uma educação catequética e proselitista. Sabe-se que para o(a) professor(a) de Ensino Religioso, um ensino que proponha o respeito a diversidade religiosa e a construção de um conhecimento religioso pautado na formação para cidadania é um desafio cotidiano. Este artigo propõe uma análise do Ensino Religioso, na perspectiva das Diretrizes Curriculares do município de Cariacica, no Espírito Santo. Através desta análise, será possível fazer uma reflexão da possibilidade que este currículo traz de um Ensino Religioso que propicia o respeito a diversidade cultural e religiosa.
CIÊNCIAS DAS RELIGIÕES E DIVERSIDADE RELIGIOSA: CAMINHOS PARA REFLEXÕES DOCENTES NO CONTEXTO ESCOLAR
Authors: MENASSA DA SILVA ROSA AMELIA
Published: November 2022

O objetivo do artigo parte da premissa que visa a aplicação do conhecimento da área das Ciências das Religiões para a promoção e respeito à diversidade religiosa no contexto escolar, não somente através da disciplina de Ensino Religioso, como garante a Base Nacional Comum Curricular (BNCC), mas em todas as outras áreas do conhecimento. Dessa forma, acredita-se que o princípio desse processo será através de orientações feitas aos docentes; considera-se que a forma mais eficaz será através da ressignificação da formação continuada já elaborada pelos órgãos competentes do sistema educacional, pois, mesmo com leis e currículos específicos que garantem respeito à diversidade religiosa, faz-se necessário orientar o discente quanto às suas práticas pedagógicas, devido à ampla diversidade religiosa presente nas escolas, visando evitar práticas proselitistas e assegurando a educação para a paz no âmbito escolar.
Bulgakov, Sergii. The Apocalypse of John: An Essay in Dogmatic Interpretation
Authors: Mcgeoch Graham G.
Published: November 2022

Resenha: Bulgakov, Sergii. The Apocalypse of John: An Essay in Dogmatic Interpretation. Münster: Aschendorff Verlag, 2019.
A ideia do mal no comentário ao Gênesis de Santo Agostinho
Authors: Martins Filho José Reinaldo Felipe , Souto Pinto Ana Kelly Ferreira
Published: November 2022

O problema do mal perpassa todas as culturas, sendo a questão que move inicialmente o pensamento filosófico-teológico de Agostinho de Hipona. Neste estudo, apresenta-se o conceito agostiniano de mal à luz dos comentários ao livro do Gênesis. Entende-se, com base em Agostinho, que toda obra de Deus é boa e, portanto, não pode se corromper em essência. O mal, por consequência, surge do uso indevido do livre arbítrio. A fim de ilustrar a argumentação desenvolvida, recorre-se a algumas das principais imagens constantes na narrativa do pecado da desobediência, conforme disponível no Gênesis, tais como a questão do trabalho como punição, o fruto da árvore proibida, além, notadamente, dos papeis de Adão, Eva e da serpente na formulação do enredo. Como pano de fundo permanece a discussão agostiniana a respeito do mal como consequência do uso degenerado da liberdade.
Percursos da hegemonia cultural bolsonarista e a retórica de ódio na realidade brasileira contemporânea
Authors: Gabatz Celso , Rosângela Angelin
Published: November 2022

Esta abordagem busca descortinar uma análise da conjuntura na perspectiva das tensões relacionadas a uma guerra cultural e suas implicações no cenário brasileiro contemporâneo. Por meio de uma exposição histórica acerca das origens do termo no ambiente intelectual estadunidense, o artigo traz à tona críticas feitas ao “marxismo cultural” em suas ligações com a governança brasileira. A despeito de uma noção epistemológica bastante confusa na base das premissas delineadas pela hegemonia cultural bolsonarista, o artigo deixa evidente que as questões referidas possuem relevância semântica para impulsionar um projeto de poder ao amplificar uma retórica que dissemina o ódio, evoca conspirações e performances escatológicas, revelando um desejo de retorno a uma ordem moralista idealizada.
Experimental Counterexample to Bell’s Locality Criterion
Authors: Mardari Ghenadie N.
Published: November 2022

The EPR paradox was caused by the provision that quantum variables must have pre-existing values. This type of “hidden property realism” was later falsified by Bell’s Theorem. Accordingly, the physical basis for action-at-a-distance between entangled quanta was removed. Yet, modern interpretations present Bell’s inequality as a Locality Criterion, as if Bell violations can only happen at the quantum level, and only with remote interactions. This is a questionable practice, considering that classical joint measurements also violate such inequalities for mutually exclusive wave properties. In particular, consecutive measurements of polarization produce the same coef-ficients of correlation as parallel measurements with entangled quanta, yet they are explicitly local. Furthermore, it is possible to combine parallel and consecutive measurements of Type I polariza-tion-entangled photons in a single experiment, conclusively showing that quantum Bell violations can be local. Surprisingly, classical phenomena also require nonlocal interpretations if pre-existing properties are taken for granted. Hence, the solution is to reject the models with pre-existing properties for both classical and quantum wave-like phenomena.
Determination of Optimum Outlet Slit Thickness and Outlet Angle for the Bladeless Fan Using CFD
Authors: Joshi Vedant , Noronha Wedyn , G Vinayagamurthy , Ramasamy Sivakumar , K B Rajasekarababu
Published: November 2022

Toshiba devised the bladeless fan (or Air Multiplier) concept in 1981. Researchers like James Dyson and Jafari et al. further developed it. Bladeless fans are more energy-efficient, safer due to the hidden blades, easier to clean, and more adjustable than conventional fans. From a performance point of view, bladeless fans are better because they multiply mass flow rate, eliminate buffeting, consume less power, and are quieter. This paper investigates the influence of the airfoil’s outlet slit thickness on the discharge ratio by varying the outlet slit thickness of an Eppler 473 airfoil from 1.2 mm to 2 mm in intervals of 0.2 mm. Results indicated that smaller slits showed higher discharge ratios. The airfoil with a 1.2 mm slit thickness showed a discharge ratio of 18.78, a 24% increase from the discharge ratio of the 2 mm slit. The effect of outlet angle on the pressure drop across the airfoil was also studied. Outlet angles were varied from 16∘ to 26∘ by an interval of 2∘. The airfoil profile with a 24∘ outlet angle showed a maximum pressure difference of 965 Pa between the slit and leading edge. In contrast, the 16∘ outlet angle showed the least pressure difference of 355 Pa. Parameters such as average velocity, turbulent kinetic energy, the standard deviation of velocity and outlet velocity magnitude was used to assess the performance of airfoil profiles used in bladeless fan.
Neurophysiological Evaluation of Students’ Experience during Remote and Face-To-Face Lessons. A Case Study at Driving School
Authors: Simonetti Ilaria , Tamborra Luca , Giorgi Andrea , Ronca Vincenzo , Vozzi Alessia , Aricò Pietro , Borghini Gianluca , Sciaraffa Nicolina , Trettel Arianna , Babiloni Fabio , Picardi Manuel , Di Flumeri Gianluca
Published: November 2022

Nowadays, fostered by technological progress and contextual circumstances such as economic crisis and pandemic restrictions, remote education is living a growing deployment. However, this growth generated widespread doubts about the actual effectiveness of remote/online compared to face-to-face education. The present study aimed at comparing face-to-face and remote education through a multimodal neurophysiological approach. It involved forty students at a driving school, during a real classroom, experiencing both the modalities. Wearable devices to measure brain, ocular, heart and sweating activities were employed in order to analyse the students’ neurophysiological signals to obtain insights about their cognitive dimension. In particular, four parameters were considered, the Eye Blink Rate, the Heart Rate and its Variability and the Skin Conductance Level. Also, the students filled a questionnaire at the end to obtain an explicit measure of their learning performance. Data analysis showed a higher cognitive activity, in terms of attention and mental engagement, in presence with respect to remote modality. On the other hand, students by remote felt more stressed, in particular during the first part of the lesson. Analysis of questionnaires demonstrated worst performance by remote, thus suggesting a common “disengaging” behaviour when attending remote courses, thus undermining their effectiveness. In conclusion, neuroscientific tools could help to obtain insights about mental concerns, often «blind», such as attentional decreasing and stress increasing, as well as their dynamics during the lesson itself, so allowing to define proper countermeasures to emerging issues when introducing new practices into daily life.
New Insights into the Biological Activities of Carboxymethylated
Authors: Pires Matheus Cerdeira , Andriolo Natalia de Gois , Lopes Bruno Rafael Pereira , Delarmelina Camila , Duarte Marta Cristina Teixeira , Ruiz Ana Lucia Tasca Gois , Do Nascimento Valeria Marta Gomes , De Toledo Karina Alves , Dos Santos Catarina
Published: November 2022

Lasiodiplodan, an exocellular Lasiodiplodia theobromae β-glucan exopolysaccharide (LaEPS), has at-tracted interest because of its antioxidant, antimicrobial, anti-inflammatory, and antiproliferative properties. LaEPS carboxymethylation enhances LaEPS water solubility and biological activities. However, carboxymethylated fractions of LaEPS (LaEPS-C): LLaEPS-C (Linear) and BLaEPS-C (Branched) were not widely studied yet. So, LaEPS-C, LLaEPS-C, and BLaEPS-C were assessed for their antioxidant, antimicrobial, antiproliferative, anticoagulant, immunomodulatory, and anti-viral activities. Elementary Chemical Composition Analysis confirmed their structural charac-teristics by Energy Dispersive X-Ray Detector (EDS), Fourier Transform Infrared (FTIR), Nuclear Magnetic Resonance (NMR), and Scanning Electron Microscopy (SEM) techniques. The best DPPH scavenging potential was achieved for LLaEPS-C for concentrations lower than 200mg/mL. LaEPS-C showed moderate antiproliferative activity for the NCI-ADR/RES cell (GI50 65.3 µg/mL), and BLaEPS-C showed weak activity for the K562 cell (GI50 235 µg/mL). LLaEPS-C had a reduced Prothrombin Time (PT) and a procoagulant effect. LLaEPS-C and BLaEPS-C are inducers of pro-inflammatory activity due to their ability to induce TNF-α in human macrophages. LLaEPS-C also showed anti-hRSV, which confirmed the antiviral activity of this molecule.
Genetic Diversity of Cytochrome P450s CYP6M2 and CYP6P4 Associated with Pyrethroid Resistance in the Major Malaria Vectors Anopheles coluzzii and Anopheles gambiae from Yaoundé, Cameroon
Authors: Fotso-Toguem Yvan Gaetan , Tene-Fossog Billy , Mugenzi Leon M.J. , Wondji Murielle J. , Njiokou Flobert , Ranson Hilary , Wondji Charles S.
Published: November 2022

Assessing the genetic diversity of metabolic resistance genes such as cytochrome P450s helps to understand the dynamics and evolution of resistance in the field. Here, we analysed the polymor-phisms of CYP6M2 and CYP6P4 associated with pyrethroid resistance in Anopheles coluzzii and An. gambiae, to detect potential resistance markers. Field-caught resistant mosquitoes and susceptible lab-strains were crossed and F4 was exposed to permethrin for 15min and 90min to discriminate highly susceptible (HS) and highly resistant (HR) mosquitoes respectively. Significant permethrin mortality reduction was observed after pre-exposure to PBO, suggesting P450s genes involvement. QPCR analysis revealed significant over-expression of CYP6M2 (FC=19.57 [95%CI 13.96-25.18] for An. coluzzii; 10.16 [7.86-12.46] for An. gambiae) and CYP6P4 (FC=6.73 [6.15-7.30] An. coluzzii; 23.62 [26.48-20.76] An. gambiae). Full-gene and ≈1kb upstream were sequenced. For CYP6M2, upstream region shows low diversity in HR and HS (overall Hd=0.49, π=0.018), whereas the full-gene shows allelic-variation but without evidence of ongoing selection. CYP6P4 upstream region showed a lower diversity in HR (Hd=0.48) than HS (Hd=0.86) of An. gambiae. These results highlighted that CYP6P4-associated resistance is potentially driven by modification in upstream region. However further work is needed to determine the real causative variants which will help design rapid detec-tion tools.
Kaposi’s Sarcoma-associated Herpesvirus ORF21 Enhances the Phosphorylation of MEK and the Infectivity of Progeny Virus
Authors: Yamaguchi Tatsuo , Watanabe Tadashi , Iwaisako Yuki , Fujimuro Masahiro
Published: November 2022

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, is the causative agent of Kaposi’s sarcoma, Castleman’s disease, and primary effusion lymphoma. Although the functions of the viral thymidine kinases (vTK) of herpes simplex virus-1/2 and varicella zoster virus are well understood, that of KSHV ORF21 (an ortholog of vTK) is largely unknown. Here, we investigated the role of ORF21 in lytic replication and infection by generating two ORF21-mutated KSHV BAC clones: ORF21-kinase activity deficient-KSHV (21KD) and stop codon-induced ORF21-deleted-KSHV (21del). The results showed that both ORF21-mutations did not affect viral genome replication, lytic genes transcription, or the production of viral genome-encapsidated particles. ORF21 molecule-dependent function, other than the kinase function of ORF21, was involved in the infectivity of progeny virus. ORF21 was expressed at 36 h after induction of lytic replication, and endogenously expressed ORF21 was localized in the whole cytoplasm and decreased on the cell surface area. Moreover, the effects of ORF21 expression on signaling pathways and proliferation were analyzed. The results showed that ORF21 upregulated the MEK phosphorylation and anchorage-independent cell growth. These findings indicate that ORF21 plays key roles in both infection and oncogenesis of KSHV through the manipulation of cellular function.
FORMATION OF LEADERSHIP COMPETENCE OF FUTURE PSYCHOLOGISTS BY MEANS OF PSYCHOLOGICAL AND PEDAGOGICAL TRAINING IN THE PROCESS OF PROFESSIONAL TRAINING
Authors: Pidbutska Nina , Martynenko Yevhenii
Published: November 2022

Abstract: the article found out that the formation of leadership competence among future psychologists is now becoming acutely relevant. Based on the research of scientists, the essence of the concepts of “leader” and “leadership competence” was considered. The study states that the effective formation of leadership competence takes place through the individual's acquisition of successful leadership experience in simulated training situations. In order to check the effectiveness of the psychological and pedagogical training, aimed at forming the leadership competence of future psychologists, we organized a pedagogical experiment, the ascertainment stage of which took place in the autumn semester of the 2021/2022 academic year of the NTU “KhPI”.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 19.11.2022 г. по 25.11.2022 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: November 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 19.11.2022 г. по 25.11.2022 г.
Türkiye’de Etik Liderlik ve Etik Kodlar Üzerine Yapılan Lisansüstü Tezlerin Analizi: Sistematik İncelemeye Yönelik Nitel Çalışma
Authors: BATTAL Fetullah , SEYREK Emre
Published: November 2022

Bu araştırma Türkiye’de 2006-2022 yılları arasında yazılan etik liderlik ve etik kodlar konulu lisansüstü tezlerin genel bir örüntüsünü ortaya koymayı amaçlamaktadır. Türkiye Yükseköğretim Kurumu Ulusal Tez Merkezi’nde (YÖKTEZ) 1 Ocak 2022 – 15 Şubat 2022 tarihleri arasında etik liderlik ve etik kodlar anahtar kelimeleriyle yapılan arama sonucunda 151’i etik liderlik ve 11’i etik kodlar olmak üzere toplam 162 lisansüstü teze ulaşılmıştır. Araştırmanın evren ve örneklemini oluşturan 162 lisansüstü tez, tür ve sayıları, yayınladığı yıllar, hazırlandığı üniversiteler, alanları, yayın dilleri, danışman unvanları, amaç, kapsam ve yöntem parametreleri çerçevesinde sistematik derlemeye dayalı analiz edilmiştir. YÖK TEZ ’den elde edilen verilere betimsel analiz ve içerik analizi uygulanarak araştırma soruları kapsamında yorumlanmıştır. Araştırma sonucunda en fazla lisansüstü tezin 2019 yılında yazıldığı tespit edilmiştir. Lisansüstü tezlere en çok Dr. Öğr. Üyesi unvanlı akademisyenlerin danışmanlık yaptığı fark edilmiştir. Lisansüstü tezleri yayınlandığı dil bakımında ele alındığında en çok Türkçe olarak yayınlandığı anlaşılmıştır. Lisansüstü tezler amaç kapsam ve yöntem bakımından ele alındığında ağırlıklı olarak eğitim öğretim ve işletme alanında yer alan örgütsel davranış konuları ile ilişkilendirildikleri sonucuna ulaşılmıştır. Araştırma sistematik derleme ve değerlendirme üzerinden yapılması açısından önem arz etmenin yanı sıra ulusal literatüre katkı sunması açısından çalışmanın değerini artırmaktadır.
Integrated Optimization of Hybrid Steam-Solvent Injection in Post-CHOPS Reservoirs with Consideration of Wormhole Networks and Foamy Oil Flow
Authors: Hou Senhan , Gu Daihong , Yang Shikai , Yang Daoyong , Zhao Min
Published: November 2022

In this paper, integrated techniques have been developed to optimize performance of the hybrid steam-solvent injection processes in a depleted post-CHOPS reservoir with consideration of wormhole networks and foamy oil flow. With the experimentally determined properties of injected gases and reservoir fluids by performing PVT tests, history matching of the reservoir geological model is completed through the relationship between fluid and sand production profiles and reservoir pressure. Meanwhile, the wormhole network has been inversely determined with the newly developed pressure-gradient-based (PGB) sand failure criterion. Once the history matching is completed, the calibrated reservoir geological model is used to optimize the solvent(s) and CO2 concentrations, provided that thermal energy, injection rates, and flowing bottomhole pressures are chosen as the controlling variables. The genetic algorithm has been modified and used to maximize the objective function of net present value (NPV) while delaying the displacement front as well as extending the reservoir life with optimal oil recovery under various strategies. Depending on the formation pressure and temperature, soaking time is optimized as a function of solvent concentration and fluid properties. Subsequently, considering the wormhole network and foamy oil flow, such a modified algorithm can be used to allocate and optimize the production-injection strategies with the NPV as the objective function.
Field Trial of Nitrogen-Assisted Cyclic Steam Stimulation in Post-CHOPS Wells, Case Study in Sudan
Authors: Tang Xueqing , Yu Chunxu , Bai Yang , Lu Hui , Mohamed Mohamed Salaheldin
Published: November 2022

This paper presents the key aspects of nitrogen-assisted cyclic steam stimulation field trial at Post-CHOPS wells in FNE field, Sudan. FNE field is a heavy-oil asset with compositional gradient (13.87 to 18.1°API, in-situ viscosity of 226 to 255 cp) in massive unconsolidated sandstones at depths of 1,500 to 1,900 ft, with a permeability of 2 to 9 Darcies and strong bottom-water drive. Initially, cold heavy oil production with sand (CHOPS) was applied to exploit easy oil at upper zones of entire play. When flow rates of CHOPS wells declined to economic limits, or producers were too cool (reservoir temperature 111°F) to pump efficiently, nitrogen-assisted cyclic steam stimulation was to increase reservoir pressure, decrease heavy-oil viscosity, and boost well production. The specific technical points are highlighted below:

In-house studies, including viscosity reduction test and numerical simulations, recommended that steam volume (cold-water equivalent) of 11,442 bbl per cycle based on 268 bbl/ft, with 70 to 75% quality, will be injected into the reservoir at rate of 1,260 bbl/d, nitrogen injection volume per cycle is 4.75 MMscf, soak time is for 5 to 7 days to allow the heat and pressure to distribute more uniform through the reservoir, then go to puff process. Pump is set 30-60 ft below the lowermost perforations to maximize fluids production through keeping fluid-level well below bottom perforations. By the end of pumping, bottomhole flowing pressure can declined to 70 psi. Steam and nitrogen injection sequence at updip wells is to inject steam first, followed by nitrogen injection. For downdip wells, nitrogen injection is the first and steam injection comes later to mitigate water influx. Re-completion strategy: squeeze cement into CHOPS producing zones because they contain wormholes, some communicating with aquifer, and perforate the lower pay interval to extract more viscous heavy oil. Failure risk assessment of production casings: pre-tensioning and full cementing of the casing with thermal cement is adopted in CHOPS wells for post-CHOPS thermal operation. Initial flowback flow rate is limited to less than the level of 500 bbl/d to reduce sanding risk and does not unduly de-pressure the formation at initial production. During pumping process, all fluids are exploited up the tubing string and the annulus is vented the flow-line. Pump works at optimal rate to ensure pressure drawdown less than critical drawdown threshold for sanding and water coning.

Field data confirmed that this trial is successful, with 2 to 3-fold production gain, relatively low water cut and no sanding issue. This technology is a useful option for post-CHOPS wells in the similar heavy-oil assets.
Data-Driven Decision-Making Strategy for Thermal Well Completion
Authors: Izadi Hossein , Roostaei Morteza , Mahmoudi Mahdi , Rosi Giuseppe , Stevenson Jesse , Tuttle Aubrey , Sutton Colby , Mirzavand Rashid , Leung Juliana Y. , Fattahpour Vahidoddin
Published: November 2022

Various wellbore completion strategies have been developed for thermal wells in Western Canada. The idea in this paper is estimating the improvement of oil production and steam injection if flow control devices (FCDs) will be installed for the next wells to be drilled, or if FCDs were installed at a particular well-pad that has not yet been completed with any FCDs. The approach is based on labeled real data for 68 well-pads from seven major thermal projects in Western Canada.

Three phases make up the paper's methodology. The first phase compares wells with and without FCDs to evaluate the performance of the FCDs based on normalized oil production and cumulative steam oil ratio (cSOR). The second phase involves clustering well-pads using an unsupervised incremental-dynamic algorithm. An estimation of FCD contribution to enhancing oil production and cSOR is also performed for test well-pads based on their most similar cluster. In the third phase, cross-validation is employed to ensure that the estimation is trustworthy, and that the procedure is generalizable.

To evaluate the performance of FCDs, a reliable comparison was made using normalized oil production and cSOR. Based on our analysis from October 2002 to March 2022, successful FCD deployment resulted 42% more normalized oil and a 37% reduction in cSOR. Among these, liner deployed (LD) FCDs increased oil production by 44% while decreasing cSOR by 58%. Although tubing deployed (TD) FCDs are installed in problematic wells, they produced 40% more oil while decreasing cSOR by 21% in successful cases. Successful inflow control devices (ICDs) increased oil production by 40% while lowering cSOR by 45%. Successful outflow control devices (OCDs) increased oil production by 82% while reducing cSOR by 22%. The clustering algorithm separates the database into four clusters that will be utilized in the estimating phase. In the estimation phase, ten well-pads (15% of the database) are presumed to be new well-pads to be drilled (test data). Based on the estimation results, the root mean square errors (RMSEs) for FCDs contribution to enhancing oil production and cSOR for the test well-pads are 12%. Cross-validation was also performed to assess the approach's predictability for new data, to verify that our technique is generalizable.

The findings indicate that FCDs might result in lower capital expenditures (CapEx) and greenhouse gas (GHG) emissions intensity for SAGD well-pad developments, allowing them to reduce emissions. The conclusions of this research will aid production engineers in their knowledge of relative production performance. The findings may be used to examine paradigm shifts in the development of heavy oil deposits as technology advances while keeping economic constraints in mind.
Design and dynamic control of integrated synergetic controller for single penstock two-machine hydropower system
Authors: Wang Fangfang , Zeng Yun , Qian Jing
Published: November 2022

Due to the existence of hydraulic coupling in the single penstock multi-machine system, the stability time of the unit is prolonged when power disturbance occurs, which is not conducive to the stability of the power system. Based on the synergy theory, this paper builds a nonlinear model of a hydro generator unit with the single penstock two-machine system, adds the synergy factors of the governing system and the excitation system, describes the characteristics of the controlled system, and derives the control law. A simulation system is built to verify the effectiveness of the proposed method. Load disturbance and three-phase short-circuit fault are set up to compare the dynamic response effects of the PID controller with optimized parameters and the synergetic controller. The results show that the proposed control method has a better control effect in the single penstock two-machine system and can better reduce the influence of the common pipe due to hydraulic coupling, shorten the stabilization time, and ensure the stability of the system. In addition, the values of regulation and synergetic control parameters are analyzed separately to provide a reference for achieving better control.
Boosting the Earth’s “Immune System”: The Development of an “Ocean Mission Architecture Optimization”
Authors: RASSIA STAMATINA TH.
Published: November 2022

Since the 1960s, researchers have studied catastrophes and have predicted that the Earth’s Systems are moving towards a new equilibrium. We are heading towards a new Ice Age. The question is whether mankind can withstand it. 82% of the world’s largest cities are situated on coastal areas or along coastlines (cf. [4]). Urbanization and deterioration of mangroves, the marine ecology and coastal environments bring cities in the front line of impact with the climate crises. While oceans have absorbed 93% (cf. [11]) of the Earth’s greenhouse gas emissions since the 1970s, megacities continue to grow over a boiling pot. What comes next remains to be seen, yet this paper proposes the development of an “Ocean Mission Architecture Optimization” (OMAO) as a step forward in combining interconnected proactive plans for future Ocean and land-use sustainability.
Taming Large-Scale Genomic Analyses via Sparsified Genomics
Authors: Alser Mohammed , Eudine Julien , Multu Onur
Published: November 2022

Searching for similar genomic sequences is an essential and fundamental step in biomedical research and an overwhelming majority of genomic analyses. State-of-the-art computational methods performing such comparisons fail to cope with the exponential growth of genomic sequencing data. We introduce the concept of sparsified genomics where we systematically exclude a large number of bases from genomic sequences and enable much faster and more memory-efficient processing of the sparsified, shorter genomic sequences, while providing similar or even higher accuracy compared to processing non-sparsified sequences. Sparsified genomics provides significant benefits to many genomic analyses and has broad applicability. We show that sparsifying genomic sequences greatly accelerates the state-of-the-art read mapper (minimap2) by 1.54-8.8x using real Illumina, HiFi, and ONT reads, while providing a higher number of mapped reads and more detected small and structural variations. Sparsifying genomic sequences makes containment search through very large genomes and very large databases 72.7-75.88x faster and 723.3x more storage-efficient than searching through non-sparsified genomic sequences (with CMash and KMC3). Sparsifying genomic sequences enables robust microbiome discovery by providing 54.15-61.88x faster and 720x more storage-efficient taxonomic profiling of metagenomic samples over the state-of-art tool (Metalign). We design and open-source a framework called Genome-on-Diet as an example tool for sparsified genomics, which can be freely downloaded from https://github.com/CMU-SAFARI/Genome-on-Diet.
Accessible mental well-being intervention for adolescents in school setting- Single-Group Intervention Study with a Pretest-Posttest Design
Authors: Tornivuori Anna , Kronström Kim , Aromaa Minna , Salanterä Sanna , Karukivi Max
Published: November 2022

Background
A growing number of adolescents seek treatment for mental health problems, which stresses the importance of studying and implementing accessible treatment options. The objective of this study was to evaluate the impact of a brief, mental well-being intervention for adolescents in a school-environment. Mental health interventions are often targeted at specific disorders, we aimed for a generic approach thus reaching adolescents with a large range of mental health symptoms.
Methods
Single-Group Intervention Study with a Pretest-Posttest Design. The intervention was conducted in secondary, upper secondary and vocational schools for adolescents aged 12–18, who sought medical attention due to mental health symptoms (n = 124). The cut-off point for inclusion was ≥14 points for the Young Persons Clinical Outcomes for routine Evaluation (YP-CORE) measure. The intervention included six visits and was implemented by school nurses that had received a three-day training course. The impact of the intervention was evaluated immediately after the six visits (n = 85) and at six-month follow-up (n = 68). The participants’ mental well-being was assessed by YP-CORE, Beck Depression Inventory (BDI-II) and Overall Anxiety Severity and Impairment Scale (OASIS).
Results
Participants reported significant levels of mental distress at baseline, YP-CORE mean score = 21.48, BDI-II mean score = 23.60, OASIS mean score = 10.98. The post-intervention results at six weeks for the primary outcome YP-CORE showed a significant (p < .001) mean score decrease of -3.82 and a medium effect size d = .627. Long-term outcomes at six months showed a -1.14 decrease (p = non-significant) and effect size d = .175. After the six-visit intervention, only 12% of the participants were assessed not to require additional visits.
Conclusions
The studied easily available intervention in school- settings was effective for adolescents with mild to moderate mental disorder symptoms. After the six-week intervention, significant positive effects were observed. The participants reported substantial levels of mental distress at baseline, which could contribute to the relapse of the YP-CORE and symptom mean scores during the follow-up and the need for extended care. Although the YP-CORE scores rose, they did not reach the baseline level indicating that slight positive changes remained.
Functional asymmetry of interleukin-1 and interleukin-6 in focal epilepsy patients
Authors: Varoglu Asuman Orhan , Avarisli Aysenur , Keskin Havva , Erman Hayriye
Published: November 2022

Objective: In the development of epilepsy, interleukin-1 (IL-1) and interleukin-6 (IL-6) play critical roles. We sought to understand the clinical significance of IL-1 and IL-6 by comparing the blood levels of individuals with left-lateralized focal epilepsy and those with right-lateralized focal epilepsy.
Method: Sixty epilepsy patients aged 18–60 with lateralized seizures and 32 healthy controls were included. Clinical and demographic data of patients were collected. We compared the levels of IL-1 and IL-6 of the patients in the interictal period.
Results: Nineteen patients (31.7%) had seizures lateralized to the right hemisphere, while 41 (68.3%) were lateralized to the left hemisphere (p < 0.001). Both IL-1 and IL-6 levels were lower in all patients than in controls (p < 0.001). Both interleukin levels did not significantly differ between right and left-lateralized seizures (p = 0.44). In the left-lateralized seizures, IL-1 levels correlated with epilepsy duration (p = 0.006), onset age (p = 0.050), and prenatal risk (p = 0.028).
Conclusion: Epilepsy patients had lower IL-1 and IL-6 levels than controls. In terms of these interleukins, there was no differentiation between left-lateralized seizures and right-lateralized. The number of patients with lateralized left hemispheres was higher than with the right hemispheres. IL-1 level was correlated with epilepsy duration, onset age, and prenatal risk in the left-lateralized seizures.
Causes of Claims in Building Construction Projects
Authors: Ahmed¹ Marwa , Badawy² Mohmed , Attia³ Tarek , Zahir⁴ Amr
Published: November 2022

The authors have requested that this preprint be removed from Research Square.
Sequential bond energy, binding energy and structures of Be+.(H2)1-3 complexes
Authors: Dawoud Jamal N.
Published: November 2022

The binding energy and structures of the Be cations with H2 molecules are studied theoretically at the level of the MP2 method. In this study, the aug-cc-pVTZ basis set is used to describe the electronic configuration of these atoms in these complexes. The structures of these complexes are determined for the \({Be}^{+}\bullet {\left({H}_{2}\right)}_{1-3}\) complexes. A tee and a vee shaped structure are obtained for mono- and di-ligated complexes, respectively. The tri- ligated complex is found to have trigonal prism geometry. The sequential bond energies of the \({Be}^{+}\bullet {\left({H}_{2}\right)}_{1-3}\) complexes are also examined. Differences in the electrostatic interaction energies and repulsive forces among H2 ligands in these complexes could be the cause of the variety in the observed trend in sequential bond dissociation energy values.