bluuebunny/crossref_metadata_2025 huggingface dataset:
Statistical Literacy Ability of Students through Virtual Learning Environment Based on Moodle-Learning Management System
Authors:   Mathematics Education Department of Institut Pendidikan Indonesia, Indonesia, Maryati Iyam
Published: February 2024

Statistical literacy skills in the era of society 5.0 are needed to overcome various problems. But interest in studying statistics is still relatively low. Thus, the learning process must be able to synergize between learning materials (content), learning methods (pedagogy), and learning media (technologi). The moodle-learning management system is one of these advances in education. If the moodle-learning management System is appropriately constructed to facilitate the usage of many platforms, users can utilize it as a learning environment with any device. This study aims to observe statistical literacy skills through the moodle-learning management system. Participants were selected from among sophomore students at the Indonesian Institute of Education: 32 people made up the control group, while 32 made up the experimental group. The results demonstrate that, at a significance level of 0.05, the experimental group’s statistical literacy abilities are substantially different from those of the control group. Students in the experimental group had literacy abilities that were 90.31% greater than those in the control group, which had literacy abilities that were 67.47%. These findings suggest that students’ statistical literacy skills are impacted by the Moodle learning management system.
Bridging the BAME Divide: Unveiling the Impacts of Covid-19 on Ethnic Minority Students and Empowering Change—A Case Study at the Open University
Authors:   School of Computing and Communications, STEM, The Open University, Milton Keynes, UK, Kbaier D.
Published: February 2024

This study investigates the evolving impact of COVID-19 on the learning experiences and study performance of ethnic minority students enrolled in Level 1 Computing modules at the Open University. A mixed-methods approach combining quantitative data analysis, literature review, and two focus groups was employed to provide fresh insights. Findings from the literature and focus groups highlight persistent challenges faced by ethnic minority students, including economic disadvantage, digital divide, housing instability, employment difficulties, family responsibilities, mental health issues, racism, discrimination, and unconscious bias. Importantly, this study reveals the dynamic nature of these challenges, illustrating how they have evolved throughout the ongoing pandemic. The study underscores the pivotal role of structural and institutional factors in shaping students’ ever-changing experiences. In response to these dynamic challenges, recommendations include targeted interventions, policy revisions that reflect the shifting landscape, innovative community-building initiatives, a renewed focus on diversity promotion, enhanced support services, unconscious bias training, and revised tuition strategies. Addressing these dynamic challenges is crucial for fostering equitable educational opportunities and outcomes for ethnic minority students. This research significantly contributes to promoting equality, inclusivity, and a more comprehensive understanding of the ever-evolving experiences of ethnic minority students during the pandemic and beyond.
Development of Special Assignments for Online Group Learning
Authors:   Department of Educational Technology, Faculty of Arts and Educational Sciences, Middle East University, Amman, Jordan, Al-Said Khaleel
Published: February 2024

The research purpose is to develop and evaluate the effectiveness of special vocabulary and grammar tasks for groups learning English online. The sample consisted of 100 students from Middle Eastern University in Jordan. The scholar used an experimental method and methods of observation, description, comparison and testing to investigate the problem. The results showed that online English learning based on special practical assignments and involving lexical and grammar tasks can improve the level of student’s language knowledge and their conversational skills. The resulting value confirmed the statistically significant difference between the test results and improvements in the experimental group. The research found that the experimental group showed better speaking skills compared to the control group. It is recommended to integrate similar practical tasks into educational curricula to foster quality education and the development of conversational skills among students studying the English language in an online environment. This approach has proved to be advantageous for instructors of professionally oriented English language courses, equipping them with an effective tool to enhance the quality of instruction and facilitate the linguistic aptitude growth of their students. Such a pedagogical format fosters active participation and collaboration among students, potentially contributing to a more profound and well-rounded language acquisition process.
A Survey of Manifold Learning and Its Applications for Multimedia
Authors:   Joanneum Research – Digital, Graz, Austria, Fassold Hannes
Published: February 2024

Manifold learning is an emerging research domain of machine learning and helps to overcome the limits of standard neural networks which are restricted to Euclidean spaces. In this work, we give an introduction into manifold learning and how it is employed for important application fields in multimedia like similarity search, image classification, synthesis & enhancement, video analysis, 3D data processing and nonlinear dimension reduction. Furthermore, we present available open source software frameworks for manifold learning. One can see from this survey that manifold learning has a lot of potential for computer vision and multimedia.
Has the Development of Inter-Provincial Transportation Infrastructure Improved the Construction of China’s Unified Market?
Authors:   School of Economics and Business Administration, Chongqing University, Chongqing, China, Wang Xueyan
Published: February 2024

With the implementation of regional development policies in recent years, transportation infrastructure has greatly promoted regional economic development, but what impact it has on the construction of market integration in the local and surrounding regions has not been specifically answered. Based on the provincial panel data of China from 2010 to 2021, this paper uses the spatial panel method to study the impact of transportation infrastructure development and the construction of national unified market and its spatial spillover effects. The empirical results show that there is significant spatial auto-correlation between inter-provincial transport infrastructure and market integration. Railway density plays a greater role in promoting the national unified market. The government expenditure and foreign direct investment play a positive role in promoting the construction of a unified national market, while the dependence of foreign trade inhibits the development of market integration. In the analysis of spatial spillover effects, the direct effect of railway density is significantly higher than that of highway. The government should strengthen the quality and efficiency of railway transportation, promote the scale of foreign direct investment of enterprises, and actively promote the construction of national unified market.
Metaverse as a Cutting-Edge Platform for Attaining Sustainable Development Goals (SDGs)
Authors:   University of Mumbai, Mumbai, India, Rane Nitin Liladhar
Published: February 2024

The Metaverse, an immersive virtual reality realm where users engage with computer-generated environments, is swiftly emerging as a transformative platform poised to address and propel Sustainable Development Goals (SDGs). This research delves into the intersections between the Metaverse and SDGs, shedding light on how this cutting-edge technology can be harnessed to propel sustainable development across diverse sectors. Commencing with a comprehensive overview, the paper details the evolution, key components, and immersive capabilities of the Metaverse. Underscoring its dynamic and interactive essence, the research emphasizes the potential of the Metaverse to revolutionize conventional approaches to education, healthcare, environmental conservation, and economic empowerment. The immersive nature of the Metaverse facilitates experiential learning, enhancing education accessibility, and fostering global collaboration to fulfill SDG 4 (Quality Education). Additionally, the paper explores how the Metaverse can contribute to healthcare solutions through virtual medical consultations, training healthcare professionals, and simulating medical scenarios. Environmental sustainability takes center stage as the Metaverse serves as a platform for raising awareness about climate change, promoting sustainable practices, and simulating eco-friendly solutions. This aligns with SDG 13 (Climate Action) and SDG 15 (Life on Land), emphasizing the Metaverse's capacity to inspire real-world environmental stewardship.
Ophthalmoplegia syndrome or tolosa hunt syndrome – A review
Authors: Kumar Sunil
Published: February 2024

Ophthalmoplegia syndrome or Tolosa Hunt syndrome (THS) is a rare severe unilateral periorbital headache associated with painful and restricted eye movements (ophthalmoplegia) with no visual deterioration. It is associated with choric inflammation with granulomatous deposition in cavernous sinus and at superior orbital fissure.

This article provides a detail outlook of this syndrome that along with pathophysiology, the present diagnostic considerations and management insights on Tolosa-Hunt syndrome through review of published article.
The pigmented puzzle: A case of cilio-choroidal melanocytoma
Authors: Ganesan Suganeswari , Jadhav Sourabh Madanrao , Subramanian Krishnakumar
Published: February 2024

A 5-year-old female patient presented with complaints of an inability to identify objects at home. Upon examination, a large retro-pupillary pigmented mass was discovered in the right eye. B-scan ultrasonography and magnetic resonance imaging (MRI) suggested a diagnosis of cilio-choroidal melanoma, leading to the decision to perform an enucleation. However, the histopathological analysis revealed the mass to be a cilio-choroidal melanocytoma, a rare benign pigmented tumor commonly associated with the optic nerve head. This case is unique due to the patient's young age, the unusual tumor location, and its larger size compared to previous reports. This case underscores the importance of considering melanocytoma in the differential diagnosis of pigmented intraocular tumors, especially given its clinical resemblance to malignant melanoma.
Phytochemical and pharmacological review of cynodon dactylon grass with its potential effects
Authors: Amritkar Shruti , Chavan Jagruti , Kakad Amit , Shaikh M.R.N.
Published: February 2024

Perennial herb Cynodon dactylon (L) Pers, family: Poeaceae, widespread throughout India. In several Indian languages, it is referred to by different names, including Durva in Marathi, Durba in Bengali, Dhro in Gujarati, Garichgaddi in Telugu, Arukampillu in Tamil, and Shataparva in Sanskrit. In traditional medical systems and ethnomedical practices, Cynodon dactylon plays a significant role. It is used in the form of powder, paste, or juice to treat a wide range of ailments due to its extensive therapeutic properties. Flavanoids, alkaloids, glycosides, terpenoides, triterpenoids, steroids, saponins, tannins, resins, phytosterols, reducing sugars, carbohydrates, proteins, volatile oils, and fixed oils were all found in Cynodon dactylon, according to the phytochemical examination. According to earlier research, Cynodon dactylon has properties that are protective, antimicrobial, antiparasitic, insecticidal, gastrointestinal, antioxidant, immunological, antiallergic, antiinflammatory, antipyretic, analgesic, anticancer, dermatological, diuretic, and immune system-related was found. In given review we studied some pharmacological aspects of Perennial herb Cynodon dactylon as well its versitile potential effect. The wide range of future aspects we can consider as best alternative medicine over chemical drugs.
1ª Mostra brasileira de literacia em saúde: Pistas para o SUS e as políticas públicas
Authors: Costa Frederico Peres da , Castro Adriana Miranda de , Leão Nicole
Published: February 2024

A Promoção da Saúde defende que para produzirmos saúde é necessário termos capacidade de reconhecer e realizar desejos e projetos, satisfazer nossas necessidades, transformar e/ou criar mecanismos de convivência com a realidade social e ambiental. Nessa direção, saúde e qualidade de vida implicam em estarmos informados para decidir sobre os rumos singulares de nossas vidas e sobre os processos de determinação social que operam no cotidiano, associando-se à ideia de autonomia. O exercício da autonomia, que se distancia muito de uma liberdade individualista e ilimitada, vincula-se à ampliação da nossa capacidade reflexiva frente ao bombardeio de informações que nos cercam e nos chegam, notadamente com a presença e expansão das tecnologias digitais. Daí a importância, em especial no campo da Promoção da Saúde, da literacia em saúde. A literacia em saúde pode ser definida como a capacidade dos sujeitos em obter, compreender, avaliar criticamente e utilizar informações sobre saúde para seu próprio cuidado ou de terceiros. Ela envolve uma ampla gama de habilidades e competências, que são desenvolvidas ao longo da vida e que possuem influência de fatores demográficos, culturais, sociopolíticos e ambientais. Com as novas e crescentes exigências de compreensão e uso de informações sobre saúde na vida cotidiana, especialmente para enfrentarmos os riscos da desinformação, é fundamental ampliar o debate acerca da literacia em saúde. Esse foi o principal objetivo da I Mostra Brasileira de Literacia em Saúde, cujas conferências e trabalhos encontram-se sistematizados neste e-book.
Finding Harmony between Decolonization and Christianity in Academia
Authors: Fainga'a-Manu Sione Inez , Faleolo Ruth , Hafu-Fetokai Cathleen
Published: February 2024

This article presents our theoretical musings on practicing decolonization as Christian Tongan academics, recorded and shared within our Australian collective during 2022-2023. We aim to discuss the strength and power that comes from our Indigenous inheritance of God and Tonga, living in diaspora of Australia and Aotearoa New Zealand (tu'a Tonga). Amidst this Indigenous strength, there are also subtleties and crescendos of coloniality taking place in and around us, as well as the complexities and vulnerabilities with which Tongan Christian academics grapple in their sense making and meaning making processes. The significance of this discussion is that Oceanian women’s opinions and experiences of decoloniality are not often considered, particularly within the contexts of academia. We pray this article offers insights into how we can successfully navigate simultaneous private, public, individual, and collective journeys, daily, as Christian academics in the decolonization of these various spaces. This is our contribution as Christian academics, as daughters of Tonga, and wives and mothers of Oceania.
The effect of ESG activities on financial performance: The moderating effect of debt ratio
Authors: Han Joohee , Jo Sung Jun
Published: February 2024

This study examined the effect of environmental, social, and governance (ESG) management on corporate performance. We collected sample data on KOSPI-listed companies in 2021 using ESG ratings released by the Korea Corporate Governance Service. The system of ratings was segmented into three distinct categories for the purpose of analysis, namely the environment, society, and governance. An empirical investigation was conducted to determine how ESG ratings and separate ratings (E, S, and G ratings) affect financial performance. We also examined the moderating impact of the debt ratio on the association between ESG ratings and financial performance to enhance the explanatory strength of this relationship. The results indicated that ESG ratings and E and S ratings are positively related to financial performance, and the debt ratio has a negative moderating effect on the link between ESG ratings related to environmental aspects and financial performance. The findings indicate that firms need ESG management to improve financial performance. ESG ratings can be utilized to show the effects of environment-focused management, sustainability, and CSR initiatives on financial performance. Additionally, the moderation effect of the debt ratio in this study clearly demonstrates the connection between ESG rating and financial performance. Our analysis also demonstrates that organizations with high debt ratios and a lack of resources to pursue ESG are unable to devote a significant amount of time and resources to ESG management.
A case study in eastern Indonesia for the development of integrated real-time performance assessment on science practicum in universities
Authors: Sudirman  , Ramdani Agus , Doyan Aris , Anwar Yunita Arian Sani
Published: February 2024

The purpose of this study was to collect preliminary data for the design of real-time and integrated performance assessments in science practicum at two public universities and two private universities in Eastern Indonesia. The case study design and quantitative and qualitative approaches were adopted in this study. Cluster random sampling technique was used to select four universities, 376 participants respectively from university students and lecturers, four vice deans, four heads of study programs, four heads of laboratories, and four teaching assistants. Data were gathered through questionnaires, in-depth interviews, and observations. The chi-square test was used to analyze the data descriptively. Findings indicated that a performance assessment was not carried out since standard measurement instruments that provided real-time and integrated feedback had not been developed. There was no significant difference (p > 0.05) between public and private universities on the science practicum assessment, implying that both public and private universities still used paper-based practicum assessments. There was also no significant difference between the responses of university students and lecturers on practicum performance assessments (p > 0.05). University students’ experience in assessing science practicums was similar to those of lecturers’, which suggests that practicum of performance assessments was not real-time and integrated with feedback. This study recommends developing a real-time and integrated performance assessment with automated feedback on the science practicum, in order to provide continuous improvement of students and monitoring their learning progress.
Effect of music engagement and movement on attentiveness and memory in children with down syndrome: A quasi-experimental research
Authors: He Hanwei , Hwa Poon Chiew , Wing Cheong Ku
Published: February 2024

Children with Down syndrome (DS) could have problems with attentiveness and memory due to innate developmental deficits. Studies have found that music can help improve the attentiveness and memory of children with DS. Orff-Schulwerk, a creative and improvisational music pedagogy, is often used to support the development of children with special needs. However, no study has used Orff-Schulwerk-based music interventions to explore their influence on the attentiveness and memory of children with DS. Therefore, this research aimed to examine the effect of music engagement and movement (MEM) on attentiveness and memory in children with Down syndrome. This quasi-experimental study involved 8-week MEM activities based on Orff-Schulwerk as the music intervention. This study recruited 18 children with DS, aged 7–10 years. MEM was used to teach vocabulary to children with DS and measured their memory and attention in classes. The results demonstrated that the attentiveness and memory of the participants were significantly improved in the MEM classes compared with the control group. The results of the paired t-test also showed statistically significant differences in attentiveness (t = 9.88, p < 0.001) and memory (t = -10.92, p < 0.001) before and after the intervention. The results of this study supported that MEM could help improve attentiveness and memory in children with DS. Implications and future directions are also discussed.
Did the PIIGS Already Fly? A Retrospective Study of the European Economy Using Data Mining Techniques
Authors: Dias Raquel , Pais Joana , Rocha Inês , Belfo Fernando
Published: February 2024

The term PIIGS was used to refer to five countries in Europe, respectively Portugal, Italy, Ireland, Greece and Spain. This nomenclature was created due to the fact that they shared similar economic and financial contexts and challenges during the 2008 financial crisis. These countries were affected by the reduction of investor confidence regarding the payment of their debts, which resulted in a significant increase in the cost of the respective debts. sovereign debts. Lack of access to adequate finance has led to bailout programs and austerity measures imposed by the European Union, European Central Bank and International Monetary Fund. This article focuses on the analysis of the economic and financial situation of the countries in question, in order to understand whether they have evolved in the face of that period. Groupings were created in order to classify the main characteristics of each group, trying to identify which European countries are in each one and, in particular, the positioning of the countries previously identified as PIIGS and their meaning. The 2008 PIIGS countries were distributed across three of the six clusters formed. The analysis of results referring to 2021 allowed to observe a significant improvement among the PIIGS countries, verifying that the name PIIGS no longer applies to the economic and financial situation of these countries. Even so, the stability of these countries' economies still needs to be improved so that they can better respond to ongoing challenges such as pandemics and wars.
Automation of Invoice Processing with ERP Integration Using RPA Tools
Authors: Santos Miguel , Trigo António
Published: February 2024

In most organizations, invoice processing is still done manually and time-consuming, because many of the invoices still come in paper form or by email. From the moment the invoice enters the organization until it is available in the management software it goes through several steps, such as, scanning, storage, approval and integration into the management software, usually an ERP system, steps that are not automated and must be performed by employees, sometimes typing all the information of the invoice in the ERP system. To automate this process, this paper presents a management information system based on Robotic Process Automation technologies.
The Emergence of a Process Tokenisation Model for the Public Sector: A Position Paper
Authors: Escobar Fernando , Santos Henrique , Pereira Teresa
Published: February 2024

Tokenisation denotes one of the most successful implementations of blockchain that concretes its benefits into practice, also in the public sector, where it can help to reverse the declining citizen trust in governments. Process Tokenisation is the possibility of adopting blockchain as infrastructure for a business process, measured by its level of “Tokenisability”. Going towards a Process Tokenisation Model for the Public Sector, this position paper presents the context in which process tokenisation is necessary for the public sector and draws on Process Virtualisation Theory to propose constructs to help a public organisation identify the most suitable business process for tokenisation. Also, a European Blockchain Service Infrastructure use case description evaluates the model. As a result, the Process Tokenisation Model for the Public Sector demonstrated valuable, foreseeing sustainable potential benefits.
Risk Factors for Multiple Violations of Protective Orders in Intimate Partner Violence Against Women
Authors: Caballé-Pérez Marta , Santos-Hermoso Jorge , López-Ossorio Juan José , Soria-Verde Miguel Angel , Amor Pedro J. , González-Álvarez José Luis
Published: February 2024

This study examined 1,134 cases of violence against women in intimate partner relationships with violations of protective orders in a monitoring period of up to 15 months. The dynamics of time and violence were analyzed in the cases of multiple violation versus one-time violation, with the objective of identifying and thus neutralizing the risk factors for this type of recidivism. The results showed that early violation, serious physical violence, death threats, as well as jealousy, harassment, and control are related to multiple violation. This article discusses the results in comparison with other research and proposes measures to avoid revictimizations.
Déterminants de l’Adoption des Variétés Améliorées de Maïs à l’Ouest du Burkina Faso
Authors: Barry Fanta , Savadogo Karim , Sanou Lassina , Dao Abdalla
Published: February 2024

Le présent article vise à analyser les déterminants de l’adoption des variétés améliorées de maïs par les producteurs au Burkina Faso. Pour ce faire, des données quantitatives ont été collectées par enquête auprès de 386 chefs de ménage sélectionnés de manière raisonnée dans onze villages de la région de la Boucle du Mouhoun. L’approche contrefactuelle basée sur l’effet moyen de traitement (ATE) a été utilisée. Les résultats ont montré que les caractéristiques importantes dans la décision d’adopter ou non les variétés améliorées par les producteurs sont le rendement élevé, le goût de la variété, la faible exigence en nutriment, l’aptitude à la conservation et la résistance à la sécheresse. Les déterminants de l’adoption des variétés améliorées de maïs ont été le prix de vente élevé du maïs, la conservation facile des graines produites et la résistance aux attaques parasitaires. Le poids du maïs dans les cultures pratiquées et la contribution du revenu de maïs aux dépenses alimentaires ont favorisé l’adoption des variétés améliorées de maïs. Le taux commun d’adoption et d’exposition est de 62 % avec cependant un écart d’adoption important de (-17%). L’amélioration du niveau d’adoption des variétés améliorées de maïs passe par une intensification de la vulgarisation.

 

This paper aims to analyze the determinants of farmers' adoption of improved varieties of maize. To do this, quantitative data were collected by a survey of 386 randomly selected heads of household in eleven villages of the region of “Boucle du Mouhoun”. The counterfactual approach based on the average treatment effect (ATE) was applied. Results showed that important characteristics in farmers' decision to adopt or not improve varieties are high yield, taste of the variety, low nutrient requirements, storage qualities, and drought resistance. Determinants of the adoption of improved maize varieties are the high selling price of maize, ease of storage of the seed produced, and resistance to pest attack. The importance of maize in crops and the contribution of maize income to food expenditure have encouraged the adoption of improved maize varieties. The common rate of adoption and exposure is 62%, although there is a significant gap in adoption (-17%). To improve the level of adoption of improved maize varieties, extension efforts need to be strengthened.
Structural Evolution and Its Implication for the Emplacement of Gold Deposit in the Central Part of Burkina Faso, West Africa
Authors: Ouedraogo Gomdebzîigè Ernest , Kagambega Nicolas , Sawadogo Sâga , Zongo Hubert G. , Ouedraogo Madi , Lompo Martin
Published: February 2024

In order to constrain the structural evolution in the central part of Burkina Faso and its implication for the emplacement of gold deposits, we undertook a structural mapping by coupling Landsat and aeromagnetic images interpretation to outcrop and core mapping followed by laboratory work. This approach reveals that the structural architecture in this locality mainly results from dextral transcurrent progressive deformation due to a NW-SE trending major stress. This architecture is similar to the Riedel-Tchalenko model. Initially, the dominant normal stress created an E-W constriction resulting in the development of N-S shear corridors. Subsequently, the tangential stress that took over this generated the progressive development of simple dextral shear zones with a NE-SW orientation that are locally taken up by ENE-WSW dextral shear bands associated with the Riedel's R structures. As a result of the cooling of the crust, we are witnessing the formation of sinistral NW-SE and dextral NNE-SSW strike-slip faults, respectively, which corresponds to Riedel's R' structures and Tchalenko's P structures. The development of NW-SE pre-Eburnean shear zones, particularly the N-S shear corridors, is synchronous with the circulation of gold-bearing fluids through the zone. However, the intersections of these directional corridors create zones suitable for gold concentration. Within these zones, ductile-brittle deformation following the emplacement of the shear bands has facilitated the remobilization and concentration of gold-bearing fluids within rocks with the appropriate rheological conditions. This is the case for Toega gold deposit.
Finding the Missing Stone: Mobile Money and the Quality of Tax Policy and Administration
Authors: Apeti Ablam Estel , Edoh Eyah Denise
Published: February 2024

Making tax administration more efficient and maximising voluntary compliance is a very difficult task for developing countries. In this paper, we analyse the effect of mobile money payments on the quality of tax policy and administration for a large sample of countries in developing economies. We use the World Bank indicator on efficiency of revenue mobilisation as a measure of the quality of tax policy and administration and employ an entropy balancing method to show that mobile money payments improve the quality of tax systems. This result is robust to several robustness tests, including sample alteration, alternative measures of mobile money, controlling for other aspects of tax policy, and alternative estimation methods such as GMM-system, event study approach and ordinary least square. In addition, our results show that the positive effect of mobile money on tax systems depends on the level of development, financial development, the state’s legitimacy, a country’s fiscal space, the number of available products/companies, the type of mobile money services, and the geographic position of countries. Finally, we highlight some potential mechanisms underlying these findings through lower tax compliance burden, smaller informal sector, and lower corruption.
Correction of mitochondrial dysfunction with trimethoxy-substituted monocarbonyl curcumin analogues in experimental Alzheimer’s disease
Authors: Pozdnyakov D. I. , Vikhor A. A. , Rukovitsina V. M. , Oganesyan E. T.
Published: February 2024

Alzheimer’s disease (AD) is a neurodegenerative disease that is a terminal form of dementia with an alarming spread rate. The treatment of AD usually involves symptomatic therapy, but the research field for new medicines to correct AD focus on the pathogenetic keys of the disease, i.e., a mitochondrial dysfunction.

The aimof the workwas to evaluate the effect of trimethoxy-substituted monocarbonyl curcumin analogues on changes in the mitochondrial function of the hippocampus in AD rats.

Materials and methods.AD was modeled in female Wistar rats by the injection of β-amyloid aggregates 1-42 into the CA1 part of the hippocampus. The tested compounds AZBAX4 and AZBAX6 at a dose of 20 mg/kg each, as well as the reference donepezil at a dose of 50 mg/kg, were administered orally for 30 days after the surgery. After the specified time had passed, the changes in the cellular respiration, a citrate synthase activity, cytochrome-c-oxidase, succinate dehydrogenase, and adenosine triphosphate (ATP) concentrations were evaluated in the mitochondrial fraction of the rat hippocampus.

Results.During the study, it was shown that the use of AZBAX4 and AZBAX6 compounds contributed to an increase in the intensity of aerobic metabolism by 83.9 (p <0.05) and 35.9% (p <0.05), respectively, while reducing the activity of anaerobic one by 27.7 (p <0.05) and 20.6% (p <0.05), respectively. Against the background of the tested compounds AZBAX4 and AZBAX6 administration, there was also a significant increase in the activity of citrate synthase, succinate dehydrogenase and cytochrome-c-oxidase, as well as the level of ATP in the hippocampal tissue by 112.8 (p <0.05) and 117.1% (p <0.05), respectively. The use of donepezil led to a significant increase in the intensity of aerobic reactions – by 24.0% (p <0.05), a citrate synthase activity– by 80.0% (p <0.05) and the ATP concentration – by 68.5% (p <0.05). Against the background of the use of the analyzed substances, a decrease in the apoptosis-inducing factor and mitochondrial hydrogen peroxide is also worth noting.

Conclusion.Based on the obtained data, it can be assumed that the use of AZBAX4 and AZBAX6 compounds contributes to an increase in the functional activity of the mitochondria of hippocampal cells of AD rats, while surpassing the reference donepezil. It is perspective to continue a further study of AZBAX4 and AZBAX6 compounds as possible medicines of a pathogenetic correction of AD.
Una concepción de los derechos para luchar contra la desigualdad económica
Authors: Monereo Atienz Cristina
Published: February 2024

La denominada desigualdad vertical es uno de los temas centrales del debate internacional de los últimos años ya que su desmedido crecimiento ha alcanzado límites intolerables en términos éticos y económicos que no pueden ser ya ignorados por nadie. Al respecto se discute la manera de abordar el problema. En concreto el movimiento de los derechos considera que puede ofrecer herramientas útiles para enfrentar esta injusta situación, mientras otros dudan de la relación entre desigualdad económica y derechos humanos y de la capacidad de los derechos humanos para luchar frente a este tipo de desigualdad. En esta tesitura se pueden distinguir posiciones “en contra”, “a favor” e “intermedias”. Analizar atentamente este debate y los conceptos que en él se manejan es de fundamental relevancia para valorar el problema de raíz que está detrás de los llamados derechos económicos, sociales y culturales, y que tiene que ver entre otras cosas con un problema de concepto y fundamentación de los derechos. Al respecto se destacan los argumentos esenciales y se muestran críticamente las definiciones y consideraciones más cuestionables con el objetivo de afianzar a continuación una noción de derechos sociales más resistente. Una solución razonable pasa por combinar el proyecto de suficiencia con el proyecto de igualdad volviendo a las bases del auténtico Estado social de Derecho que dio origen a estos derechos y que los configura como derechos de dignidad basados en la libertad real, la igualdad sustancial y también la solidaridad, ésta última prácticamente ausente en el debate.
Carlos Ramón Fernández Liesa, Juan Daniel Oliva Martínez, y Oscar Pérez de la Fuente (eds.), Soberanía
Authors: Arellano Pinzón Jaelee
Published: February 2024

Este artículo reseña: Carlos Ramón Fernández Liesa, Juan Daniel Oliva Martínez, y Oscar Pérez de la Fuente (eds.), Soberanía, Colección Gregorio Peces-Barba, Dykinson, Madrid, 2022, 172 pp.
Reply to “A Case Report about the Management of Hereditary Angioedema with Normal Complement Levels during Pregnancy”
Authors: Moura Ana Luísa , Gaspar Ângela , Borrego Luís Miguel
Published: February 2024

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População em situação de rua
Authors: Mota Juliana Ramos da , Sodré Alessandra , Santos Adriana Correia dos , Santos Lucimara Correia dos , Silva Tatiana Canuto , Voci Silvia Maria
Published: February 2024

Introdução: Apesar da invisibilidade histórica, atualmente a população em situação de rua conta com a Política Nacional para a População em Situação de Rua que tem como um dos seus objetivos implementar ações de segurança alimentar e nutricional que proporcionem o acesso permanente à alimentação, respeitando, protegendo e promovendo o Direito Humano à Alimentação Adequada. Objetivo: Conhecer a percepção da população em situação de rua a respeito da alimentação adequada, do direito à alimentação e das dificuldades vividas no cotidiano em busca do alimento. Metodologia: Trata-se de uma pesquisa qualitativa, com realização de entrevistas semiestruturadas guiadas por um roteiro e transcritas na íntegra. Os dados foram interpretados conforme a técnica de análise de conteúdo proposta por Bardin, na modalidade de análise temática. Foram entrevistados seis usuários de um equipamento socioassistencial voltado à população em situação de rua, localizada em Aracaju, Sergipe. Resultados e Discussão: Observamos que a população em situação de rua tem conhecimento sobre Direito Humano à Alimentação Adequada e reconhece a violação desse direito na necessidade de pedir alimento e passar por períodos de privação e fome. As suas dificuldades cotidianas, além de conseguir o alimento, também se referem à perda da dignidade e o sentimento de humilhação, além da exclusão do mercado de trabalho e o preconceito.  Estudos com populações em situação de rua são escassos. Há de se considerar as dificuldades em acessá-las, englobando aspectos relacionados à sua localização, aspectos relacionados a etilismo e dependência química, problemas relacionados a saúde mental, áreas de exclusão e violência.
Pembinaan Pemasaran dan Pengelolaan Keuangan pada UMKM Batik Ciwaringin Cirebon
Authors: Albari Albari , Sutrisno Sutrisno , Nurfaizi M. Iqbal
Published: February 2024

Batik is an original and typical Indonesian product which has received international recognition as an Indonesian cultural heritage which has been designated by UNESCO. The batik industry has also made a significant contribution to the Indonesian economy, where the number of batik businesses in Indonesia has reached almost 3000 business units. Of this number, 98% is the batik industry managed by small entrepreneurs. After being hit hard by the Covid-19 pandemic, the batik industry is now starting to improve. The aim of this service is to provide guidance in the form of marketing management and financial management as well as assistance to batik MSMEs under the auspices of the Ciwaringin Batik Cooperative, so that their batik business management can be better. The coaching provided is in the form of marketing management, financial management and bookkeeping. Based on the results of training and mentoring, MSME participants have been able to carry out promotions independently or jointly with cooperatives, and there has been a slight increase in sales.
Evaluation of China’s provincial eco-efficiency with the explainable boosting machine (EBM) model and Tobit regression
Authors:   School of Humanities and Management, Wannan Medical College, Li Haili , Xu Penghui ,   School of Management, Jiangsu University, Guo Shi ,   School of Management, Jiangsu University
Published: February 2024

The explainable boosting machine (EBM) model measures China’s provincial eco-efficiency, and the Tobit regression model reveals internal driving factors to provide consultation for promoting China’s green development based on the panel data of 30 provinces from 2000 to 2018. The findings of this article are as follows: provincial-level regional ecological efficiency is low, growth is slow, regional differentiation is significant, and development still has a trend of incoordination and multi-polarization. From the perspective of global autocorrelation, the Moran index is significantly positive, and the province eco-efficiency of the first grade presents a positive spatial correlation and has the characteristics of spatial agglomeration. The regression analysis results show that the economic level, the FDI, the level of technological innovation, and the level of human capital are the main influencing factors of eco-efficiency, and there are spatial differences. Relevant suggestions are based on the status and influencing factors of the unbalanced development heterogeneity of provincial eco-efficiency in China.
Laboratory Tests Might Mitigate Misdiagnosis of Child Abuse Established on Clinical Grounds
Authors: Verd Sergio , Lizarbe Elisa , Sol Elena , Tur Alicia-Esther
Published: February 2024

Given that evaluating suspected child maltreatment is a challenging task, we aimed to begin to explore how laboratory test results may assist in its detection. Hence, we have examined biomarker differences between 137 children entering out-of-home care and 126 children living in their own homes. Each child entering Majorcan institutionalized care was randomly matched for gender and age with children living in their homes and the same health area. Concerning basic hematological and biochemical values, children placed in out-of-home care differed significantly from children remaining at home in four distinct ways. Children at care entry had significantly higher eosinophil counts than children at home; and also had significantly lower levels of transaminase, thyroid-stimulating hormone, triglycerides and LDL-Cholesterol than children living at home. Oxidative stress linked to anxiety disorders and underweight are common features found in children at entry into the care system. The present study shows a relationship between some underweight or oxidative stress biomarkers and the risk of entry into out-of-home care. Medical diagnoses require physicians to select and assemble relevant data from all available information. Accordingly, we should consider the implementation of laboratory checkups in order to identify the abused from the non-abused child better.
Palmitic Acid Inhibits Cell Proliferation and Tumor Growth of Endometrial Cancer In Vitro and In Vivo
Authors: Zhao Ziyi , Wang Jiandong , Kong Weimin , Newton Meredith Anne , Burkett Wesley , Sun Wenchuan , Buckingham Lindsey , Donnell Jillian , Suo Hongyan , Deng Boer , Shen Xiaochang , Zhang Xin , Hao Tianran , Zhou Chunxiao , Bae-Jump Victoria
Published: February 2024

Epidemiological and clinical evidence have extensively documented the role of obesity in the develop-ment of endometrial cancer. However, the effect of fatty acids on cell growth in endometrial cancer has not been widely studied. Here we reported that palmitic acid significantly inhibited cell proliferation of endometrial cancer cells and primary cultures of endometrial cancer, and reduced tumor growth in a transgenic mouse model of endometrial cancer, in parallel with increased cellular stress and apoptosis and decreased cellular adhesion and invasion. Inhibition of cellular stress by N-acetyl-L-cysteine effec-tively reversed the effects of palmitic acid on cell proliferation, apoptosis and invasive capacity in the endometrial cancer cells. Palmitic acid increased the intracellular formation of lipid droplets in a time- and dose-dependent manner. Depletion of lipid droplets by blocking DGAT1 and DGAT2 effectively increased the ability of palmitic acid to inhibit cell proliferation and induce cleaved caspase 3 activity. Collectively, this study provides new insight into the effect of palmitic acid on cell proliferation, inva-sion and the formation of lipid droplets that may have potential clinical relevance in the treatment of obesity-driven endometrial cancer
Toplumsal Uyum ve Yabancılaşma Sarkacında Erken Dönem [15-17. Yüzyıl] Osmanlı-Sırp İlişkileri
Authors: ABİDOĞLU İsa
Published: February 2024

Bu makale, Osmanlı döneminde Sırp kültürünü ve onun çeşitli yönlerini ele almakla birlikte özellikle Osmanlı Devleti’nin Hıristiyan tebaasına karşı belirli bir pragmatik tutum sergilediği erken dönemlerde, Sırpların yerel uygulamalarında ve sosyo-kültürel örüntülerinde ortaya çıkan dönüşüme odaklanmaktadır. Osmanlı Devleti, kendi yönetim kültürüyle çelişecek birtakım politikaları yürürlüğe sokmayı göze alarak Balkanlarda Sırplardan oluşan gayrimüslim tebaayı kendi feodal-idari ve sosyo-politik yapısına uyarlamayı başarmış ve bu sayede egemenlik nüfuzunu kalıcı kılabilmiştir. Osmanlı Devleti söz konusu yönetim refleksini her şeyden önce kendi siyasi, kültürel ve toplumsal sürekliliğini koruma amacıyla ortaya koymuştur. Makale aynı zamanda Sırp toplumunda Osmanlı tebaası olma süreciyle görülmeye başlayan kültürel ve dini senkretizm olgusuna odaklanmakta ve bu olguyu senkretizm karşıtı eğilimlerle ilişkili olgularla bağlantılı olarak analiz etmektedir. Öte yandan bu makalede temel amaç, Sırp kültürünün Osmanlı Rumeli’sinde gelişen çok etnikli, çok dinli ve çok dilli ortak bir kültür inşa etme süreci üzerindeki etkisini göstermektir. Bu amaç doğrultusunda elde edilen bulgularda Sırp toplumunun, yerel beylikler ve Osmanlı yöneticileri arasında süregelen ilişkilerde denge unsuru haline geldikleri ve bu hal ile birlikte Osmanlı ordusunda çeşitli kademelerde görev alarak imparatorluğun savunmasına katkıda bulunma imkanını elde ettikleri görülmektedir. Söz konusu durum Sırplara din-toplum-yönetim etkileşimi açısından dinamik bir yapıyı kazandırmış ve onları Osmanlı devlet yapısına daha fazla entegre etmiştir.
Los denuestos de Antón de Montoro a Rodrigo Cota: Génesis política y social de su sátira y algunas cuestiones relativas a su linaje y descendencia judeoconversa
Authors: Cáseda Teresa Jesús Fernando
Published: February 2024

Resumen: Este estudio sitúa el linaje de Antón de Montoro y plantea algunas cuestiones relevantes sobre sus orígenes. Y, asimismo, lo encuadra en las coordenadas sociales y políticas de su tiempo. Respecto a lo primero, analiza su punto de vista sobre la persecución de los judíos en Castilla y en Córdoba; y sobre lo segundo, lo ubica políticamente en la lucha que mantuvieron entonces las dos familias más poderosas de Córdoba, la del conde de Aguilar y la del conde de Cabra, sobre las que habla repetidamente en sus composiciones. Finalmente, examina su poema dedicado a Rodrigo Cota, un ejemplo de los diversos puntos de vista sobre el concepto de judeoconverso en el otoño de la Edad Media.
Palabras clave: Antón de Montoro. Rodrigo Cota. Córdoba. Literatura siglo XV.
Voices from Transit Zones: A Study of Humanitarian Interpreting Challenges
Authors: Nuc Blazic Aleksandra , Iacono Katia , Orthaber Sara
Published: February 2024

This paper presents findings derived from interviews encompassing representatives of NGOs and public service institutions as well as trained and untrained interpreters within the ReTrans partner countries Austria, Slovenia, the Republic of North Macedonia and Greece. The study’s aim was to gain comprehensive insights into the specific requirements of humanitarian interpreters and service users. Additionally, it sought to illuminate the dilemmas they routinely face. The findings have shown that humanitarian interpreting frequently involves the participation of untrained interpreters, with the essential role played by cultural knowledge. Additionally, the use of a pivot language, thematic preparation, and engagement in additional tasks beyond traditional interpretation roles, such as gathering information about financial support or assisting in finding accommodation, emerge as crucial aspects of humanitarian interpreting. However, due to the scope of this paper, we will focus on specific elements within this broader context