bluuebunny/crossref_metadata_2025 huggingface dataset:
Protoporphyrin IX Associated with Visible Light for the Treatment of Trichophyton rubrum Causing Onychomycosis - An Updated Review
Authors: Taliari Matheus Alexandre Da Silva , Fontes Andressa Costa , Araujo Fellipe Genasculi , Pereira Luis Lênin Vicente , Simonato Luciana Estevam , Pinto Neto José Martins , Lozano André Wilian , Boer Nilton Cesar Pezati , Da Silva Wagner Rafael , De Aquino Rafael Guerra , De Arruda Farid Jamil Silva , Prates Fábio Zanusso , De Freitas Noedi Leoni , Taliari Jean Donizete Silveira , Ramos Rogério Rodrigo
Published: June 2022

Systemic medications used during the treatment of onychomycosis caused by Trichophyton rubrum may have relapse, making them costly and insignificant for the patient. Photodynamic therapy (PDT) is an advantageous therapeutic option for disease control, mainly due to the absence of risk of microbial resistance. The action of PDT is combined by three elements: photosensitizer (PS), visible light (VL) and molecular oxygen, leading to the formation of reactive oxygen species (ROS) or singlet oxygen formation (1O2), both ROS (type I mechanism) as 1O2 (type II mechanism) induce damage and death to microbial cells. This research was proposed as a study through a non-systematic review, to investigate the action of PS "Protoporphyrin IX" (Pp IX) associated with visible light on T. rubrum, contemplating clinical and relevant data regarding the treatment of onychomycosis by PDT. PubMed survey was conducted from June 2021 to April 2022. The research strategy included clinical trials, randomized trials, systematic reviews, meta-analyses and reviews in English. Pp IX has affinity for T. rubrum, which is justified by the incorporation of Pp IX into the cell membrane, which led to inhibition by LV irradiation. Thus, the photodynamic process of Pp IX may lead to cell death by type I and II mechanisms. The data found are promising, however, new studies in vitro and in vivo are suggested, since few studies have been found related to the theme.
Studying and Analyzing Operating Conditions of Hollow Fiber Membrane Preparation Process
Authors: Rashad Zaid
Published: June 2022

Polymeric hollow fiber membrane is produced by a physical process called wet or dry/wet phase inversion; a technique includes many steps and depends on different factors (starting from selecting materials, end with post-treatment of hollow fiber membrane locally manufactured). This review highlights the most significant factors that affect and control the characterization and structure of ultrafiltration hollow fiber membranes used in different applications.    
   Three different types of polymers (polysulfone PSF, polyethersulfone PES or polyvinyl chloride PVC) were considered to study morphology change and structure of hollow fiber membranes in this review. These hollow fiber membranes were manufactured with different process conditions and a reasonable starting point for factors remained constant to study the changing effect of specific factors.
The joint AU-EU Innovation Agenda: when Science, Technology and Innovation (STI) stand for Sustainable Tangible Impact
Authors: Lorusso Vincenzo , Venturi Piero , Seke Lukovi , Teshome Mahlet , Idinoba Monica Ebele , Masheleni Hambani , Buisman Nienke , Hoegel Jens
Published: June 2022

Outcome of the African Union (AU) – European Union (EU) Research & Innovation (R&I) Ministerial Meeting of July 2020, the “AU-EU Innovation Agenda” aims to turn R&I investments into tangible businesses, services and jobs. This Agenda proposes specific objectives with short-, medium- and long-term actions for all four priority areas of the AU-EU cooperation in Science, Technology and Innovation (STI), namely (i) Public Health, (ii) Green Transition, (iii) Innovation and Technology and (iv) Capacities for Science. This paper aims to raise awareness on the AU-EU Innovation Agenda and the ongoing public consultation on its working document (open until 30 June 2022). This consultation will gather feedback and input from citizens, stakeholders and their respective organisations, through an online survey (https://ec.europa.eu/eusurvey/runner/IAPublicConsultation). This is done to ensure that the Agenda will address actual unmet needs on the ground, to ultimately maximise chances to provide for sustainable and inclusive growth in Africa and Europe.
SCREENING OF GENETIC VARIANTS, PHYTOCHEMICAL ANALYSIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF Physalis minima FRUITS EXTRACT
Authors: Pradeepkumar Sobiya , Muthukrishnan Suriyavathana , Eswaran Anandhi , Kumar Nirubama , Ganesan Thamaraiselvi , R. Jayaprakash
Published: June 2022

Medicinal herbs are playing a major role in the therapeutic field due to the combination of phytochemicals and are the alternatives to chemical drugs. Physalis minima fruit has also exhibited multiple biological activities due to its richness in vitamins, minerals, and antioxidant chemicals. This work investigated the phytochemical variations of the genetic variants collected from four districts around Salem, Namakkal, Erode, and Dharmapuri with the help of polymerase chain reaction and random amplified polymorphic DNA methods. Phytochemicals of the fruits were examined through thin layer chromatography using chloroform, diethyl ether, ethanol, ethyl acetate, and methanol extracts. The polar solvent ethanol crude extract was characterized by FT-IR and GC-MS analysis to identify the functional groups. The antimicrobial activity of ethanolic extracts of Physalis minima fruits was evaluated against Streptococci acidominimus, Pseudomonas aeuriginosa, Penicillium expansum, and Aspergillus fumigatus strains by the cup diffusion method using serially diluted ethanolic extracts of Physalis minima fruit. The sample’s inhibition zones were compared with 25µl of the standards such as tetracyclin and fluconazole. The genetic variants were identified through the RAPD analysis and proved to have both phenotypic and genotypic characteristics in Physalis minima fruits. The thin-layer chromatography outcomes exposed the presence of phytochemicals in an evident manner, and the antimicrobial activity of the fruits exhibited good inhibition against the selected pathogens. The fruit extracts showed good inhibition between 1.5 mm and 5 mm against bacteria. Likewise, 0.5mm to 2.18mm was observed against fungus pathogens.
APPLICATION OF TARTARIC ACID DERIVATIVES IN ENANTIOSEPARATION OF RS-IBUPROFEN
Authors: Jadhav D.N. , P. Nag  , Lokhande R. S. , Chandorkar J. G. , Sharma S. K.
Published: June 2022

A novel Tartaric acid derivative-based chiral resolving agent has been discovered for the enantiosepration of racemic Ibuprofen [(RS)-2-(4-(2-methyl propyl) phenyl) propanoic acid]. The processinvolves optimization of diastereomeric salt formed between (+) Ibuprofen and optically pure tartaric acid derivatives, followed by separating the individual enantiomer by acid salt preparation. Characterization of the synthesized compound has been carried out by elemental analysis, melting point, FT-IR, UV, HPLC, and 1H NMR spectra. The developed separation method is simple, cost-effective, and industrially viable.
In-silico ANALYSIS AND MOLECULAR DOCKING STUDIES OF NOVEL THIAZOLIDINEDIONE DERIVATIVES AGAINST PPAR-γ
Authors: B. Geetha  , N. Harikrishnan  , P. Sharmili  , Rani E. Esther , A. Haripriya  , Hemalatha C. N.
Published: June 2022

Type 2 Diabetes mellitus (T2DM) is one of the immunometabolic disorders that are distinguished by hyperglycemia persisting over a period of time. Thiazolidinediones are the drugs that activate the Peroxisome proliferator-activated receptors (PPARs). Materials and Methods: A sequence of new Thiazolidine 2,4-dione derivatives was designed with ChemDraw software. In silico predictions like PASS prediction, Molinspiration, and Acute rat toxicity prediction with the help of GUSAR software were done. Results: Based on the results, the designed derivatives were docked with the target protein Peroxisome Proliferator-Activated Receptor Gama (PPARγ) (Pdb Id: 7AWC). Conclusion: Compounds T6, T5, T7, T9, T63, and T11 showed the maximum potency and binding affinity to the PPAR-γ receptor when compared to the rosiglitazone as standard. From the docking score, it is quite clear that the substitution of the fluorene ring to the thiazolidine 2,4- dione nucleus increases the antidiabetic activity.
THE MORPHOLOGICAL AND CHEMICAL CHARACTERIZATION OF ENCAPSULATED POWDER IN RODENT TUBER MUTANT PLANT (Typhonium flagelliforme) EXTRACT
Authors: Sianipar N. F. , S. Yuliani  , K. Assidqi  , R. Purnamaningsih
Published: June 2022

The rodent tuber mutant plant (Typhonium flagelliforme) has anticancer properties. This plant contains several bioactive compounds such as hexadecanoic acid, alpha-tocopherol, octadecanoic acid, stigmasterol, and eicosane. However, the utilization of rodent tuber mutant plant extract as a functional food is not optimal yet. One of the things that need to be done to make processed products from rodent tuber mutant plant extract is a functional beverage that has benefits like cancer prevention through emulsions. This study was used as a spray drying method, which is a process for making microparticles from necessary materials with a coating to protect active ingredients from the outside environment. The sample used was the rodent tuber mutant plant extract. The encapsulate agents were used maltodextrin, whey protein concentrate (WPC), and soy protein isolate (SPI). This study aimed to investigate the bioactive compounds and microparticles characteristics in rodent tuber mutant plant extract powders. Nanoemulsion produced from rodent tuber mutant extract was applied for the encapsulation process with several different composition ratios. The compositions were consists of maltodextrin (3), maltodextrin, WPC, SPI (2:1:1), maltodextrin & WPC (2:1), maltodextrin & SPI (2:1). The results revealed that encapsulation using maltodextrin, WPC & SPI (2:1:1) had better microparticle characteristics, and still contained bioactive compounds which were used as an anticancer such as hexadecenoic acid/ palmitic acid (6.23%), octadecadienoic acid/ stearic acid (5.24%), and oleic acid (2.15%)
In-silico SCREENING OF FLAVONOIDS AS AgrA INHIBITORS BY MOLECULAR DOCKING, NORMAL MODE ANALYSIS, AND ADMET STUDY
Authors: Basak Hriday Kumar , Paswan Uttam , Karmakar Sujoy , Chatterjee Abhik
Published: June 2022

Excessive and prolonged intake of antibiotics results in the emergence of antibiotic-resistant pathogenic bacterial strains. As a consequence, managing bacterial infections with currently available antibiotics is extremely challenging. In order to tackle the bacterial resistance, bacterial communication mechanism, especially bacterial quorum sensing (QS) is targeted. In agr QS system, the various gene expression involved in the secretion of virulence factors can be attenuated by inhibiting the DNA-AgrA interactions. Here, we docked twenty flavonoids with previously homology modeled AgrA proteins together with PDB ID: 4G4K (template protein of the homology models) using the AutoDock tool. Out of twenty flavonoids, three flavonoids (dracorhodin, acacetin, and oroxylin A) exhibited promising binding free energies (<-9.00 kcal/mol). We also performed a normal mode analysis to check the stability of docked complexes. The best-docked complexes are stable as indicated by normal mode analyses. The best three flavonoids (dracorhodin, acacetin, and oroxylin A) possess desirable drug-likeness attributes. Hence, these compounds can act as novel AgrA inhibitors
STRUCTURE MODIFICATION: EFFECT OF LIPOPHILIC, ELECTRONIC, AND STERIC PARAMETERS OF N-BENZOYLN'-PHENYLTHIOUREA COMPOUNDS ON ANTIVIRAL ACTIVITY OF COVID-19 BY IN SILICO
Authors: D. Kesuma  , Makayasa C.H.A. , F. Suhud  , Azminah  , Yuniarta T. A. , Sumartha I. G. A. , Risthanti R. R. , Dani F. F.
Published: June 2022

N-benzoyl-N'-phenylthiourea (BFTU) compound is similar to amprenavir derivatives in the urea compound, chloroquine in the -NH group, and the benzene ring, which is a potent antiviral. This study evaluated the effect of lipophilic, electronic, and steric parameters of the BFTU compound on the antiviral activity of Covid-19. In silico docking using Autodock 4.2 to confirm the activity and pkCSM webserver to predict bioavailability and toxicity. The SARS-CoV-2 receptor was binding pocket with the Protein Data Bank (PDB) code 6LU7. Two and three dimensions of BFTU were generated using Marvin Sketch 20.4 and UCSF Chimera. Steric parameters affected the antiviral activity more than lipophilic and electronic parameters. A linear relationship was obtained on lipophilic, steric, and electronic parameters on activity, and a non-linear was on bioavailability and toxicity. The best activity was predicted for the N-benzoyl-N'-2,4-dichloro-phenylthiourea compound with a docking score of -9.12 kcal/mol. BFTU compounds are more potent as antiviral activity of Covid-19 compare to the reference drugs.
QSAR STUDY OF PYRAZOLE-UREA HYBRID COMPOUNDS AS ANTIMALARIAL AGENT VIA PROLYL-tRNA SYNTHETASE INHIBITION
Authors: Sumartha I. G. A. , Yuniarta T.A. , D. Kesuma
Published: June 2022

Aminoacyl-tRNA synthetase is one of the emerging potential targets for various tropical diseases such as malaria. One of which, prolyl-tRNA synthetase, has known to possess diverse binding modes such as dual inhibitor with febrifugine and the recently elucidated allosteric site. A recent study showed that pyrazole-urea hybrid analogues are a potential selective inhibitor agent against this enzyme. Here, we have created a quantitative structure-activity relationship (QSAR) model using multiple linear regression (MLR) and a partial least square (PLS) regression approach. Due to the limited amount of available data, the double cross-validation (DCV) method was employed to overcome a bias which resulted due to some data points being held out for validation. Several optimizations were performed to obtain the best result, namely different data splitting strategies (random and rational) and different correlation threshold values (0.8 and 0.9). Finally, the two best equations obtained from MLR and PLS approaches were evaluated by checking their applicability domain. It is found that the MLR output model yielded the best result, which indicated the significance of Geary autocorrelation and CATS-2D-based descriptors in representing the correlation between pyrazole-urea hybrid analogues and their enzymatic activity.
Origen’s Exegesis and Theology in the Interpretation of Jer. 1, 6: ‘I do not know how to speak because I am too young’
Authors: Кожухов Сергий
Published: June 2022

В исследовании рассматривается экзегеза и богословие Оригена на одно из мест книги пророка Иеремии: Я не умею говорить, ибо я слишком молод (Иер. 1, 6). Каждый пророк, по мнению Оригена, является символом Христа. Исходя из этого, Ориген рассматривает вышеуказанный текст, развивая его толкование в христологическом ключе. Иеремия не умел говорить, поскольку был молод, но он символ Христа. В таком случае можно ли и Христу приписать подобное неумение говорить? Ориген отвечает на этот вопрос положительно, проводя различие между Божеством и человечеством Христа. Экзегеза Оригена идёт в привычном для него ключе: Писание - слово Божие, и оно должно быть подобающим образом истолковано с пользой для христиан.

The article analyzes Origen’s exegesis and theology in the interpretation of the passage from the book of Jeremiah (1, 6): I do not know how to speak because I am too young. Every prophet, according to Origen, is a symbol of Christ. Basing on this, Origen considers the above text, developing its interpretation in a Christological way. Jeremiah could not speak because he was young, but he is a symbol of Christ. In this case, is it possible to attribute similar properties to Christ? Origen answers this question positively, making a distinction between the Deity and the humanity of Christ. Origen’s exegesis proceeds in the usual way: Scripture is the word of God and should be properly interpreted for the benefit of Christians.
Transformational Leadership and ‎Organizational Commitment: ‎‎‎Moderating Role of Emotional ‎Intelligence in HEI s in Afghanistan
Authors: Rahmani Najmuddin , Khan Kaleemullah
Published: June 2022

Academic leaders have a very important role to play in higher educational institutions, and for ‎the development of academic leaders, attention has to be paid to their emotional intelligence to ‎ensure transformational leadership and effective decision-making in their institution. This is ‎because, with the passage of time, the roles of academic leaders have also changed. In the present ‎study, the focus is on the transformational leadership style of academic leaders as it is more ‎prevalent in the higher education institutions in Kabul Afghanistan. This study analyzed the ‎moderating role of Emotional intelligence (EI) of employees on the relationship between ‎transformational leadership (TL) and organizational commitment (OC) in the private higher ‎education institutions in Kabul. The population of the study is the employees of the academics ‎and employees of the 7 private universities in Kabul from that 270 are sample size and the ‎technique used is convenience sampling. The statistical result found that EI acts as a moderator ‎on the relationship between transformational leadership and organizational commitment. This ‎study provides leaders with a new insight to look at their employees ‘level of commitment to ‎their organization. In addition, this study further helps in exploring the impact of employees’ ‎emotional intelligence on the relationship between transformational leadership and different ‎components of organizational commitment. Different aspects of these variables were tested, to ‎provide a wider and more comprehensive understanding of the factors that affect organizational ‎commitment in private higher education institutions in Kabul.‎
The Use Of The Concept Of Restorative Justice Against The Criminal Act Of Murse In The Policepekanbaru City Resort
Authors: Fahmi Fahmi , Iqsandri Rai , Rizana Rizana
Published: June 2022

Criminal law regulations must be in accordance with the justice system. The justice system in Indonesia is made so that there is justice for the community. One of the existing laws is criminal law. the rules made in criminal law have a purpose that can provide order, a sense of security and sanctions for the perpetrators. The purpose of the existence of the rule of criminal law is to correct the perpetrator and has the aim of a deterrent effect for people who commit crimes or violations. The criminal justice system also tends to be offender oriented, where victimology as a study must aim that the victim is given the rationale that the settlement of cases outside the court is necessary. As for example, namely the settlement of criminal cases with the concept of restorative justice (restorative justice). The concept of a restorative justice approach is an approach that provides justice and balance for fair victims and perpetrators
IMPLEMENTATION OF THE RIGHTS OF PEOPLE WITH DISABILITIES IN PEKANBARU CITY BASED ON LAW NUMBER 8 OF 2016
Authors: Hidayaturrahman Hidayaturrahman
Published: June 2022

This study aims to find out about the implementation of the rights of persons with disabilities in the field of accessibility in the city of Pekanbaru based on Law No. 8 of 2016 concerning Persons with Disabilities. The purpose of this study was to analyze what efforts were made to overcome obstacles in the Implementation of the Rights of Persons with Disabilities in the City of Pekanbaru based on Law No. 8 of 2016. The methodology of this research is sociological law carried out by survey, namely direct research of research locations using tools data collection in the form of interviews and observations. Research results found in the implementation of Law No. 8 of 2016 concerning PwDs is not implemented properly as it should. clear standards and objectives, good and right resources, characteristics of the implementers of the policy, how to communicate and establish relationships between the implementing parties and the objectives, dispositions and influence of the social and economic environment. Which of the results of research in the field that these six factors have not been able to be implemented properly and correctly.
Belief in the Just World in European Culture
Authors: Andreenkova Anna
Published: June 2022

General belief in the justice, in well-ordered and balanced social relations, the system where people get what they deserve is described in the concept of M. Lerner as “belief in the just world” (BJW). BJW helps to justify existing inequalities, to cope with unjust life situations, to keep optimistic view, but can also be a barrier for questioning and changing of unfair social relations. The research based on data of 9th round of Russian social survey (RSS) and European social survey (ESS) conducted in 30 countries revealed the prevalence of rational-skeptical view of Europeans on the chances of general justice. The average level of BJM appeared to be relatively low in Russia and in most other countries included in the analysis. To confirm the methodological rigor of these conclusions, the evaluation of statistical cross-national equivalency of BJM scale was conducted. The empirical validity of the BJW scale in Russia was assessed using cognitive interviews on randomly selected follow-up sample among RSS respondents. It showed the interpretative and motivational multidimensionality of the concept, but also the consistency of empirical semantic space of the concept to theoretical construct and general validity of the scale. Factors influencing the formation of BJW have two-fold structure. The impact of value-cultural factor leads to the similarity of views on BJW in Russia and in Europe on aggregate level. Personal situation and socio-demographic factors plays on individual level have differential impact. BJW as general worldview attitude has strong impact on framing particular socio-political attitudes and evaluations. High level of BJW is related to loyalty toward existing political system, trust to governing institutions and positive evaluation of incumbent’s performance which is consistent with findings from previous research. In opposite, the hypothesis on the impact of BJW on the support of conservative ideology and anti-liberal social attitudes was not confirmed.
“Good Night” by Byron and Kozlov as a Russian Folk Song
Authors: Suprunova Dariya A.
Published: June 2022

The article reveals the way of transformation of an excerpt from George Gordon Byronʼs poem Childe Harold’s Pilgrimage into a Russian song that has become a folk song. The author analyzes the process of adaptation of the author’s translation made by Ivan I. Kozlov to the folk environment and its further distribution and functioning as a folklore text. Attention is drawn to the changes in the figurative system, subject and composition of the original source.
“Three Paraphrastic Odes of Psalm 143”: Religion and Politics in the Poetry Contest of Trediakovsky, Lomonosov and Sumarokov in 1743
Authors: Korovin Vladimir L.
Published: June 2022

The article clarifies the circumstances of the creation of the first translations of the psalms by V.K. Trediakovsky, M.V. Lomonosov and A.P. Sumarokov, printed in the brochure “Three Paraphrastic Odes of Psalm 143” (St. Petersburg, 1744; published at the end of 1743). As it is known, they were written in connection with their theoretical discussion about Russian versification (on the semantics of the iambic and trochee) and were brought to the public as the results of a poetic contest. In this article attention is focused not on questions of style and metrics, but on the content of these poems and for the first time an explanation is given why three poets had chosen psalm 143 (in the Hebrew numbering 144) for their first transcriptions. It belongs to the “royal” psalms, it is inscribed “Psalm of David about Goliath”, and in the final verses it has two opposite reading options: in the Greek version it is about the temporary well–being of sinners (foreign people), in the Hebrew - about the eternal bliss of the righteous (their own people). The Slavic translation was made from Greek, and the German translation by M. Luther was made from Hebrew. All three poets made interpretations according to the Slavic translation version, showing their loyalty to Orthodox Christianity, and at the same time expressing the hope that the power of the Lutheran Germans in the St. Petersburg Academy of Sciences will soon be put to an end. The allegorical religious and political meaning of the translations of Psalm 143 was revealed in comparison with the German translation and was supposed to sting the enemies of Lomonosov and Trediakovsky at the Academy of Sciences. Three odes were written in August 1743, shortly after the conclusion of the Abo Peace with Sweden (which secured another victory of the Orthodox Russians over the Lutheran Swedes, David over Goliath) and the release of Lomonosov from arrest (where he had been since the end of May due to a conflict with German professors). Аpparently, he was the first who suggested choosing psalm 143 for the poetic contest (later he will make its another interpretation according to the Hebrew version). The publication of the “Three Odes” was part of a set of events for the second anniversary of Elizabeth Petrovna’s accession to the throne, so it was supervised by the Prosecutor General of the Senate, Prince N.Y. Trubetskoy.
Feminine Writing as Seen by Zinaïda Gippius
Authors: Protopopova Anna V.
Published: June 2022

The paper examines the question of Zinaïda Gippiusʼ attitude to women's literature in the context of her views on the possibility of constructing female creative subjectivity. The article, based on the analysis of critical articles by Gippius, reveals her attitude to the work of women writers, her contemporaries, in terms of the genuine realization of female subjectivity in literature, on a par with male creativity and without imaginary opposition to it. The analysis is based on the material of literary criticism by Zinaïda Gippius of the works of Liudmila Vilkina, Ekaterina Bakunina, Lidia Zinovieva-Annibal, Poliksena Solovieva, Marina Tsvetaeva, Anna Akhmatova. At the end of the paper, it is noted that Gippius recognizes the presence of literary talent for women, but its implementation is questioned.
The Potency of Avocado Seeds (”Persea Americana” Mill.) as a Source of Antioxidant Tea
Authors: Anwar C. , Irhami I. , Aprita I.R.
Published: June 2022

The processing of avocado into avocado juice will produce organic waste, namely avocado skin, and seeds. This potential of organic waste from avocado seeds can be exploited by turning them into tea products. This study employed avocado seed as a source of antioxidants which was made into processed products, namely tea. This research was intended to discover the influence of temperature with avocado seeds on antioxidants as well as the quality of resulting tea products and to determine the best conditions for the drying process of avocado seed tea. This investigation was arranged at the Integrated Lab of Politeknik Indonesia Venezuela and the Laboratory of Banda Aceh Industrial Research and Standardization Center. The experimentation adopted a factorial completely randomized design pattern composed of 2 (two) parameters. The first parameter was avocado seed drying temperature comprising 3 (three) degrees, they were S1 (50°C), S2 (60°C), and S3 (70°C). The second parameter represented the drying time of avocado seeds which comprised 3 (three) degrees, they were L1 (2 hours), L2 (2.5 hours), and L3 (3 hours). Analysis carried out in the research was water, ash value, phenolic content, antioxidant, and sensory (colour, taste, and flavour). From the research, it was shown that the drying temperature was influenced by the moisture content, ash content, and antioxidant activity of avocado seed tea, while the drying time and the treatments of those parameters made an impact on total phenol. The best quality avocado seed tea was obtained from a drying temperature of 50°C along with a length of drying of 2 hours.
Calculation of Optimal Length for Skyline
Authors: Rudko I. , Bakay B. , Bont L.G. , Romasevych Y. , Horzov S.
Published: June 2022

As important for the design of cable logging systems both theoretically and practically, the optimization problem regarding the optimal

length of the skyline was determined. In the process of modeling the shape of the sagging curve of the holding cable, the objective function is

constructed in the form of a transcendental equation, whose roots are determined by iterative and graphical-analytical methods. A numerical

analysis of the problem is carried out. To calculate the optimal length of the skyline, a software algorithm, an engineering formula, and nomograms are proposed.
Wooden Mosques (Candi/Canti Mosques) from Anatolia’s Black Sea Region
Authors: Erarslan Alev
Published: June 2022

Wood has been used in Turkish architecture, not only in houses and warehouse structures but also intensively in the building of mosques. The mosques of the times were built in the wood masonry system and were especially abundant in regions of Anatolia that we're blessed with generous forests. The Black Sea Region particularly abounds with wooden mosques. Known as çantı mosques, these structures represent the region’s cultural wealth. The aim of this article is to describe the mosques built in the “wooden masonry system” (çantı), a group of buildings that together signify a special group of mosques in Anatolian architecture, referring to examples of these types of mosques located in the region of the Black Sea. The features of the plans, construction systems, materials, and ornamentation of these structures will be detailed in an effort to document the identity of this collective cultural legacy and as a contribution to the literature for posterity.
Jurnal Ilmu Farmasi & Farmasi Klinik ISSN : 1693-7899 e-ISSN : 2716-3814 Volume 18 No. 2 Desember 2021 Journal of Pharmaceutical Science & Clinical Pharmacy
Authors: Isi Daftar
Published: June 2022

Jurnal Ilmu Farmasi & Farmasi Klinik ISSN : 1693-7899 e-ISSN : 2716-3814 Volume 18 No. 2 Desember 2021 Journal of Pharmaceutical Science & Clinical Pharmacy DAFTAR ISI Uji Iritasi Dan Aktivitas Tabir Surya Secara In Vitro Minyak Biji Pala dalam Sistem Mikroemulsi Dengan Variasi Tween 80-Etanol Sri Eka Rahmadany, Aza Zakiyatun Nida, Risha Fillah Fithria, Ayu Shabrina……… Stabilitas Nanostructured Lipid Carrier Coenzyme Q-10 dengan Variasi Waktu Pengadukan Usrifatul Khasanah, M. Fatchur Rochman….……………………………………….. Peningkatan Disolusi Celecoxib Melalui Pembentukan Dispersi Padat dengan HPMCPEG 6000 Eva Kartalina, Danang Novianto Wibowo …………………………………………… 47-54 55-63 64-70 Aktivitas Mukolitik Ekstrak Daun Iler (Coleus atropurpureus [L.] benth.) secara In Vitro Sulastri Herdaningsih, Dian Kartikasari……….……………………………………… 71-76 Aktivitas Antioksidan Ekstrak Kulit Pisang Kepok, Pisang Mas dan Pisang Nangka Menggunakan Metode DPPH Azimatur Rahmi, Nadya Hardi, Linda Hevira………………………………………... 77-84 Perbedaan Kadar Flavonoid Total Ekstrak Daun Salam (Syzygium polyanthum) dengan Metode Refluks dari Beberapa Jenis Pelarut dan Aktivitas Antibakteri……………… 85-93 Ekstrak Etanol Daun Suji (Pleomele angustifolia) Terenkapsulasi Nanopartikel Kitosan dalam Sediaan Krim Tabir Surya dengan Variasi Tween 80-Setil Alkohol Muhammad Ridho Putra Santosa, Malinda Prihantini…………………………….…. 94-101
EVALUASI WAKTU TUNGGU RESEP OBAT TERHADAP KEPUASAN PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT ASSYIFA KOTA TANGERANG
Authors: Ekadipta Ekadipta , Zuhriyanto Muhammad , Nurahayu Siti
Published: June 2022

ABSTRACTHospital is an important health service center and is needed to meet health needs. This study aims to evaluate the waiting time for prescription non-concoction and concoction medicines based on the hospital's minimum service standards and their effect on general outpatient satisfaction at the Pharmacy Installation of RSIA Assyifa, Tangerang. This study used a descriptive research design of outpatients who redeemed non-concoction and concoction medicines. Calculation of the waiting time for prescription services for non-concoction and concoction medicine is using a digital clock. Satisfaction was measured using a questionnaire which was analyzed multivariate. The samples taken in the study were 222 respondents. The results showed that the average waiting time for prescription of non-concoction medicine (8.9 minutes) and concoction medicine (16.6 minutes) had met the standards set by the hospital's SPM in the pharmaceutical sector according to the Minister of Health of the Republic of Indonesia NO. 129 of 2008 and by RSIA Assyifa. The results in the multivariate analysis obtained t = 10.126 and the standard coefficient of 0.88, indicating that waiting time has a strong positive effect on patient satisfaction with prescription of non-concoction and concoction medicine services at RSIA Assyifa.Keywords: patient satisfaction, prescription service, waiting time
The Development of Project-Based E-Learning Tool to Improve Students' Creative Thinking Skill
Authors: Ahmad Nurul Qomariyah , Yustinaningrum Bettri
Published: June 2022

This study aimed to determine the form, the level of effectiveness, and the obstacles and challenge in developing project-based e-learning tool to improve students’ creative thinking skills. The learning media developed are syllabus, lesson plans, modules, and creative thinking skills test. The model which is developed is the Plomp model which consists of some phases namely investigation, design, realization/construction phases and the evaluation, revision, test phase. Based on the validation test, the syllabus was 4.48, the RPS was 4.48, the module was 4.36, and the THB was valid. Based on the practicality test, the students’ responses were 76.25% and the lecturers’ responses were 4.70 and the category is very good. Based on the individual effectiveness test of 43.8% > 5%, classical completeness z count = 0.976 is between the z table and the N-gain test, 2 students had increasing creative thinking ability test scores in the high category, 6 students were in the medium category. Then it can be concluded that the learning tools developed are valid, effective, and practical.
Requirement Analysis for an Intelligent Warning System to Alarm the Rapid Response Team Prior to Patient Deterioration
Authors: Rostam Niakan Kalhori Sharareh , Deserno Thomas M.
Published: June 2022

The early warning system alarms the rapid response team (RRT) for clinical deterioration monitoring and prediction. Available systems do not perform well to decrease the number of ICU transfers or death. This study aimed to address the requirement of an intelligent warning system for timely and accurate RRT activation. Methodology: A literature review was conducted in scientific databases to extract data. Then, a questionnaire was developed for experts’ views collection (N=12). The collected data were analyzed using the Content Validity Ratio (CVR). According to the Lawshe table for the corresponding number of experts, the cut-off=0.56 for items to be accepted/rejected was considered. A schematic structure was suggested. Findings: The analysis of the extracted papers (N=24) and qualitative analysis addressed 44 requirements in the frame of five involved sub-systems, including a patient monitoring system, electronic health record, clinical decision support system, remote monitoring patient, and dashboard ®istries. They were confirmed by meeting the least cut-off value (CVR= 0.86). Conclusion: An integrated approach and technologies of IoT, deep and machine learning techniques, big data, advanced databases, and standards to create an intelligent EWS are required.
The Role of Artificial Intelligence and Machine Learning During the Covid-19 Pandemic: A Review
Authors: Aldhoayan Mohammed D.
Published: June 2022

Covid-19 is one of the most significant infectious diseases that have faced humanity in the past century from clinical, economic, and social perspectives. Although the role of infectious diseases in human history has been vicious and is well known to humanity, Covid-19 is a special case since it is the first worldwide outbreak in the era of advanced computing and telecommunications. For this reason, it was only logical to see Artificial Intelligence (AI) and Machine Learning (ML) on the top of the list of controls to compact the spread of Covid-19. This paper goes through the applications of AI and ML that were reported in some of the major literature indexes and can be related to the main issues that face healthcare providers during the Covid-19 pandemic. This paper also discusses the applicability of these applications to healthcare organizations and points out the main prerequisites before they can be adopted.
ICT Tools for Registry Research: A Market Survey
Authors: Stausberg Jürgen , Harkener Sonja
Published: June 2022

Registries in health research are complex systems requiring a diverse infrastructure with information and communications technology tools (ICT tools) for manifold tasks. Those tools should support not only data management but also several core and accompanying processes. Recent trends in registry research also need to be taken into account. Thirty-five vendors, suppliers, and experts were included in a survey on ICT tools for registries and cohorts. Information from 28 tools was available for a preliminary analysis. In comparison to 2015 and 2018, coverage of core processes such as registry development or data analysis and utilization increased from below 40% to 39% and higher. Recording patient-reported information and linkage to other data collections was well covered. However, near-patient trends were less supported. The market offers a rich selection of commercial and non-commercial ICT tools for registry research. Due to the manifold offers available from the market, in-house developed software should be an absolute exception.
Impact of Follow-Up Imaging Recommendation Specificity on Adherence
Authors: Mabotuwana Thusitha , Hall Christopher S. , Hombal Vadi , Dalal Sandeep , Gunn Martin L.
Published: June 2022

Radiology reports often contain follow-up imaging recommendations, but failure to comply with them in a timely manner can lead to delayed treatment, poor patient outcomes, complications, and legal liability. Using a dataset containing 2,972,164 exams for over 7 years, in this study we explored the association between recommendation specificity on follow-up rates. Our results suggest that explicitly mentioning the follow-up interval as part of a follow-up imaging recommendation has a significant impact on adherence making these recommendations 3 times more likely (95% CI: 2.95 – 3.05) to be followed-up, while explicit mentioning of the follow-up modality did not have a significant impact. Our findings can be incorporated into routine dictation macros so that the follow-up duration is explicitly mentioned whenever clinically applicable, and/or used as the basis for a quality improvement project focussed on improving adherence to follow-up imaging recommendations.
Time Bias Awareness in ECG-Based Multiple Source Data Matching
Authors: Albrecht Urs-Vito , Lawin Dennis , Kuhn Sebastian , Kulau Ulf
Published: June 2022

For cardiological datasets acquired via different methodologies, ECG signals that are recorded in parallel allow for relatively accurate matching. Some research issues, e.g., the identification of timings of the cardiac cycle in seismocardiography, require higher temporal resolutions. Therefore, we introduce a method derived from a feasibility study to determine deviations and factors influencing the merging of signals simultaneously recorded with different modalities.
Data Protection in Healthcare Research: Medical Students’ Knowledge and Behavior
Authors: Farah Marialida , Helou Samar , Tufenkji Pascal , El Helou Elie
Published: June 2022

Healthcare research involves handling personal health information. Information security policies are implemented in research institutions to ensure data subjects’ rights but are not always respected due to researchers’ neglect or unawareness. This paper is part of an action research project at Saint Joseph University in Lebanon aiming to increase researchers’ compliance with the university’s information security policy. An anonymous online questionnaire was administered to medical students to evaluate their knowledge and behavior regarding patient data handling in research projects. 38 responses were collected. Results show that most students collect patient data for research, and are frequently not aware of, and do not comply with, the existing information security policy. We also found correlations between low knowledge and non-compliant behaviors including clicking on links from unknown senders, leaving computers unattended, and sharing data insecurely. To address these issues, we plan to implement various Information Security Awareness interventions and compare their effectiveness.
Contextualizing Online Laboratory (lab) Results and Mapping the Patient Journey
Authors: Joseph Amanda L. , Monkman Helen , MacDonald Leah , Kushniruk Andre W.
Published: June 2022

The 21st century has brought forth unprecedented technological advances, such as the advent of portable digital devices [1]. This trend has also permeated the health care sector, with the introduction of digital health services, like providing citizens with access to their online laboratory (lab) results. This qualitative study will illustrate the patient journey, namely participant 16 (P16), to address the research question: what phases does a person go through when accessing their lab results online? The findings revealed that lab results were accessed from two types of devices a tablet (e.g., portable computer) when at home and a mobile phone when away from home. We also found that interpretation of results can be a challenge and it was unclear if P16 was able to understand her lab results. To illustrate the complexity of interpreting and accessing online lab results, the authors created a Customer Journey Map to contextualize the experiences of P16. The journey map depicts a combination of factors such as: eHealth literacy, limited access to providers, difficulty interpreting lab test results. Additionally, recommendations for online lab portal functionality enhancements were discovered through the mapping exercise. This study demonstrated that along with providing citizens with access to digital health technologies and services, considerations to eHealth literacy, the digital divide and health equity are paramount. As evidenced by the visualization, journey maps hold promise to serve as efficient tools to build empathy and identify the unique needs and perspectives of citizens.
COVID-BIOCHIP: A Web Tool to Analyse COVID-19 Antigen Microarrays
Authors: Sucre Aurora , Amaya-Rodriguez Isabel , Rho Hee-Sool , Serna Sonia , Reichardt Niels , Garin-Muga Alba , Epelde Gorka
Published: June 2022

During the COVID-19 pandemic, there was a growing need to characterise the disease. A very important aspect is the ability to measure the immunisation extent, which can be achieved using antigen microarrays that quantitively measure the presence of COVID-related antibodies. A significant limitation for these tests was the complexity of manually analysing the results, and the limited availability of software for its analysis. In this paper, we describe the development of COVID-BIOCHIP, an ad-hoc web-based solution for the automatic analysis and visualisation of COVID-19 antigen microarray data results.
Comparison of Data Classification Results for Leap Motion Recovery Gestures
Authors: Nicola Stelian , Chirila Oana-Sorina , Stoicu-Tivadar Lacramioara
Published: June 2022

Static and dynamic gestures are frequently used in activities supporting learning, recovery healthcare, engineering, and 3D games to increase the interactivity between man and machine. The gestures are detected via hardware devices and data is processed using different software methods. This paper presents the manner of detection and interpretation of two gestures, a hand rotation gesture and a palm closing and opening gesture, using the Leap Motion device. These two dynamic gestures are very often used in hand recovery exercises. For comparing the two gestures we use data classification methods, Support Vector Machine (SVM) and Multilayer Perceptron (MLP). The data for the gesture classification were 80% training data and 20% testing data. The metrics for comparison are precision, recall, F1-score, and the total number of testing cases (support). The SVM classifier gives an accuracy of 99.4% and the MLP classifier a 96.2%. We built two confusion matrices for better visualizing the results.
Information Technologies for Cognitive Decline
Authors: Farsirotos Gina , Babic Ankica
Published: June 2022

Information technology (IT) is used to establish diagnosis and provide treatments for people with cognitive decline. The condition affects many before it becomes clear that more permanent changes, like dementia, could be noticed. Those who search for information are exposed to lots of information and different technologies which they need to make sense of and eventually use to help themselves. In this research, we have systematically analyzed the literature and information available on the Internet to systematically present methods used in diagnosing and treatment. We have also developed an artifact to help users obtain information with help of illustrations and text. The final user groups are all those for whom the cognitive decline is of concern. Medical professionals could be interested to direct their patients to use the artifact to gain information and keep learning at their own pace.
Comparing Themes Extracted via Topic Modeling and Manual Content Analysis: Korean-Language Discussions of Dementia on Twitter
Authors: Lee Haeyoung , Jang Sun Joo , Sun Frederick F. , Broadwell Peter , Yoon Sunmoo
Published: June 2022

We randomly examined Korean-language Tweets mentioning dementia/Alzheimer’s disease (n= 12,413) posted from November 28 to December 9, 2020, without limiting geographical locations. We independently applied Latent Dirichlet Allocation (LDA) topic modeling and qualitative content analysis to the texts of the Tweets. We compared the themes extracted by LDA topic modeling to those identified via manual coding methods. A total of 16 themes were detected from manual coding, with inter-rater reliability (Cohen’s kappa) of 0.842. The proportions of the most prominent themes were: burdens of family caregiving (48.50%), reports of wandering/missing family members with dementia (18.12%), stigma (13.64%), prevention strategies (5.07%), risk factors (4.91%), healthcare policy (3.26%), and elder abuse/safety issues (1.75%). Seven themes whose contents were similar to themes derived from manual coding were extracted from the LDA topic modeling results (perplexity: -6.39, coherence score: 0.45). Our findings suggest that applying LDA topic modeling can be fairly effective at extracting themes from Korean Twitter discussions, in a manner analogous to qualitative coding, to gain insights regarding caregiving for family members with dementia, and our approach can be applied to other languages.
Collecting Data from Senior Citizens Using Serious Games
Authors: Karthan Maximilian , Romahn Paul , Pryss Rüdiger , Kestler Hans , Schobel Johannes
Published: June 2022

Training cognitive skills of people suffering from dementia by using serious games has been found to be a successful approach. But there is still no approach which takes advantage of performance measurements to evaluate the treatment of the patient. The literature describes several games which aim to improve cognitive skills, but none of them collects and analyses data while the patient is playing the latter. In this work we present a prototypical mobile application which applies concepts from serious games to collect performance data of patients and thereby evaluate the success of their treatment in the long run. We expect this approach to be a fast and cheap way of keeping track of the success of specific treatments.