bluuebunny/crossref_metadata_2025 huggingface dataset:
USER ACTIVITIES ON SOCIAL MEDIA: APPLICATION OF SMMA MEASUREMENT SCALE
Authors:   University of Dubrovnik, Faculty of Economics and Business, Matic Sosic Matea , Vojvodic Katija , Brajkovic Tea
Published: December 2024

The aim of this study is to examine differences in user activities based on their attitudes towards communication and advertisements by companies on social media. The survey questionnaire was created using the Google Forms tool, and the research was conducted in April and May 2022. Multivariate statistics, factor analysis, and analysis of variance (ANOVA) were used to obtain relevant results. Through factor analysis of the SMMA (Social Media Marketing Activities) measurement scale, three factors were identified: interactivity factor, informativeness factor, and motivational-experiential factor. The analysis of variance revealed significant differences in the extracted factors and the attitudes towards the communication of companies on social media, as well as in users' purchase intentions. The results of the variance indicated a statistically significant difference between the informativeness factor and attitudes towards advertisements on social media. Furthermore, further analysis confirmed that there are no significant differences between the interactivity factor and the motivational-experiential factor concerning attitudes towards advertisements appearing on social media.
HOW TO SUPPORT P2P BUSINESS IN THE SHARING ECONOMY: UNDERSTAND GENERATIONAL DIFFERENCES IN CUSTOMER MOTIVATIONS IN DRIVING DEMAND FOR IDLE ASSETS
Authors:   Technical University of Liberec, Liberec, Czech Republic, Pelech Pavel , Dedkova Jaroslava
Published: December 2024

This study explores the potential of generational segmentation as a strategy for enhancing the efficiency of peer-to-peer (P2P) platforms within the sharing economy. It focuses on how marketing messages can be tailored to stimulate demand across different generations (Generation X, Y, and Z) for idle assets within this economy. A mixed approach combining quantitative and qualitative data collection and analysis was used. Data collection was conducted in two phases. The first phase, involved the collection of qualitative data. For this purpose, exploratory research using the focus group method was used. The second phase involved quantitative data collection using an online questionnaire. To obtain responses from respondents of different generations, snowball sampling was used. Descriptive statistics, Kruskal-Wallis test, PCA and Welch ANOVA were used for data analysis. This research identified two significant motivational factors (opportunistic/user and social) and discovered generational differences in these motivations. These findings suggest that P2P platforms can leverage generational segmentation to refine their marketing communications, thereby gaining a competitive advantage and supporting business growth. It delves into the implications of these results for customer acquisition and retention strategies within the sharing economy, offering insights that could bolster the performance of P2P businesses. By harnessing the power of generational segmentation, P2P platforms can enhance their marketing effectiveness, stimulate the growth of the sharing economy, and contribute to sustainability.
Penerapan Media Power Point dengan Metode Flashcard dan Kartu Kata untuk Meningkatkan Kemampuan Penguasaan Kosa Kata Siswa Sekolah Dasar
Authors: Amini Ghina Rizkia Islahul , Thohir M. Anas
Published: December 2024

Penelitian ini membahas mengenai bagaimana media PowerPoint (PPT) dengan metode flashcard dapat meningkatkan kemampuan penguasaan kosa kata siswa. Rendahnya kemampuan penguasaan kosa kata berpengaruh terhadap hasil belajar siswa. Tujuan dari penelitian ini adalah untuk meningkatkan kemampuan penguasaan kosa kata pada siswa kelas 1 pada mata pelajaran Bahasa Indonesia. Subyek penelitian ini adalah siswa kelas 1 SD Negeri Mergosono 3 dengan jumlah peserta didik sebanyak 23 siswa. Waktu penelitian dilakukan pada saat PPL 1 tahun ajaran 2024. Penelitian dilakukan dalam 3 tahapan yaitu prasiklus, siklus 1 dan siklus 2. Data yang dikumpulkan merupakan data kuantitatif dan kualitatif. Data kuantitatif merupakan data yang diperoleh dari hasil tes formatif pada setiap siklus. Sedangkan data kualitatif berupa hasil observasi pada setiap siklus pembelajaran. Hasil dari penelitian yang dilakukan adalah peningkatan hasil belajar mencakup kemampuan penguasaan kosa kata pada setiap tahapan. Hasil belajar siswa pada tahap prasiklus hanya 10 dari 23 siswa (43,48 persen) yang mencapai nilai tuntas, pada siklus 1 meningkat menjadi 16 siswa (69,57 persen), dan pada siklus 2 meningkat menjadi 20 siswa (90 persen). Kesimpulan dari penelitian perbaikan pembelajaran menggunakan media power point dengan metode flashcard dan kartu kata dapat meningkatkan kemampuan penguasaan kosa kata siswa kelas 1 pada mata pelajaran Bahasa Indonesia.
Editorial
Authors: Rivadulla López Juan Carlos
Published: December 2024

La revisión por pares es un elemento esencial de la publicación académica y uno de los más importantes pilares del proceso científico. Por ello, desde Ápice. Revista de Educación Científica (AREC) queremos agradecer el esfuerzo y la experiencia que todos los evaluadores aportaron a las revisiones. A continuación, se incluyen los nombres y filiaciones de todos los revisores que han colaborado en el año 2023 con Ápice. Revista de Educación Científica (AREC).
Investor sentiment and Euro area ETFs: an empirical analysis of consumer behaviour
Authors: Dziuba Pavlo , Hrysenko Maryna , Shtogrin Kyryl
Published: December 2024

The goal of this article is to study the relationship between investor sentiment and Euro area Exchange Traded Funds (ETFs), providing insights into the dynamics of market behaviour and the impact of consumer behaviour on investment patterns within the Eurozone. This paper has employed panel data analysis, correlation analysis, regression analysis, and the Granger causality test to investigate the relationship between ETFs and the consumer confidence index (CCI). Results suggest that CCI significantly negatively affects ETF pricing. While a weak positive correlation and regression relationship between iShares MSCI Eurozone ETF prices and CCI 19 Euro area markets have been found, the Granger causality test did not provide evidence of a causal relationship between the two variables. Other factors, such as financial stability, government regulations, and market-specific factors, may also affect ETF prices. The study concludes that, while CCI may be important, it should not be the only factor considered.
Conocimiento del etiquetado nutricional y rotulado de alimentos envasados en la merienda escolar en adolescentes de una Institución Educativa de Asunción, Paraguay
Authors: Kabboutt Arrúa Kafi Yamili , Riveros Irigoyen María Fabiola
Published: December 2024

Introducción: El etiquetado nutricional constituye una herramienta fundamental para la toma de decisiones alimentarias informadas. El objetivo fue evaluar el conocimiento sobre etiquetado nutricional y rotulado de alimentos envasados de la merienda escolar en adolescentes de 12 a 15 años de una institución educativa de Asunción durante 2023.
Materiales y métodos: Estudio transversal descriptivo que incluyó 69 estudiantes (edad media 13±0,73 años). Se aplicó un cuestionario estructurado para evaluar conocimientos sobre etiquetado nutricional y rotulado de alimentos.
Resultados: El 88,4% identificó correctamente la información calórica, mientras que solo 40,6% reconoció la información sobre fibra. El 81,2% identificó el rotulado de exceso de azúcares. El 66,7% adquiere sus meriendas en la cantina escolar, con predominio de consumo diario de jugos envasados (31,9%) y alimentos sin etiquetado nutricional (37,7%).
Conclusión: Los adolescentes demuestran conocimiento del etiquetado nutricional, particularmente sobre calorías y azúcares, aunque este conocimiento no necesariamente influye en sus elecciones alimentarias.
Autonomía en relación con la propia muerte. Las sentencias del TC 19/2023 y 94/2023
Authors: Andreu Martínez M.ª Belén
Published: December 2024

El derecho a la autodeterminación sobre la propia muerte en determinados contextos se ha abierto paso en España a través de la Ley Orgánica 3/2021, de 24 de marzo, reguladora de la eutanasia, así como de las sentencias del TC 19/2023 y 94/2024, que declaran su constitucionalidad. En este trabajo nos centraremos en algunos aspectos planteados en estas sentencias, que son de máxima relevancia. Así, el alcance del derecho a la vida y el papel de la libre autodeterminación en la nueva configuración del derecho a la integridad personal del art. 15 CE, siguiendo la estela marcada por el TEDH. También se abordarán determinados aspectos del modelo regulatorio, como la delimitación del contexto eutanásico, especialmente en los casos de enfermedades mentales, y las carencias en relación con las situaciones de «incapacidad de hecho».
A Likelihood Ratio Test for Hybridization Under the Multispecies Coalescent
Authors: Peng Jing , Kong Sungsik , Kubatko Laura
Published: December 2024

Several methods have been developed to carry out a statistical test for hybridization at the species level, including the ABBA-BABA test and HyDe. Here, we propose a new method for detecting hybridization and quantifying the extent of hybridization. Our test computes the likelihood of a species tree that is possibly subject to hybridization using site pattern frequencies from genomic-scale datasets under the multispecies coalescent. To do this, we extend the calculation of the likelihood for site pattern frequency data for the 4-taxon symmetric and asymmetric species trees proposed in Chifman and Kubatko (2015) by incorporating an inheritance parameter, resulting in efficient computation of the likelihood under a scenario of hybridization. We use this likelihood computation to construct a likelihood ratio test that a given species is a hybrid of two parental species. Simulations demonstrate that our test is more powerful than existing tests of hybridization, including HyDe, and that it achieves the desired type I error rate. We apply the method to two empirical data sets, one for which hybridization is believed to have occurred and one for which previous methods have failed to detect hybridization.
An Insight into the Current Status of the Radiotherapy Landscape in Africa: A Cross-sectional Survey Study on the Available Infrastructure and Human Resources
Authors: Mallum Abba , Sibanda Wilbert , Tendwa Maureen , Akudugu John , Ngwa Wilfred , Incrocci L. , Vorster Mariza
Published: December 2024

Mariza Radiotherapy infrastructure and human capital are crucial for effective cancer control, yet their availability in Africa remains severely limited. This study addresses this critical gap in knowledge by providing a comprehensive assessment of radiotherapy resources across the continent. A cross-sectional descriptive web-based survey was conducted using the Research Electronic Data Capture (REDCap) system, a secure and validated online survey platform. The survey questionnaires which adhered to Content Relevance, Order, Source, and style were disseminated via email and WhatsApp to a representative sample of health professionals in 54 African countries. Data was collected through the REDCap survey while descriptive statistical methods were employed to analyze the data. In this study, 25 countries (46.3%) participated, revealing a distribution of 43 Linear Accelerators (LINAC) and 18 Cobalt-60 machines. Southern Africa (30.2%) and North Africa (30.2%) led in LINAC availability, while East Africa (38.8%) had a higher representation of Cobalt-60 machines. The healthcare practitioner distribution across Africa highlighted that the majority (35.3%) had less than four years of experience, with a minority (21.9%) having approximately 11-20 years of experience. A smaller percentage (6.0%) had over 20 years of experience, and the fewest individuals were still in training (5.0%). Most countries recorded over 20 newly diagnosed breast, cervical, and prostate cancer patients per month. North Africa had the highest proportion of practitioners administering the highest fractional dose (8.0 – 12.0 Gy). Notably, Cameroon had the longest waiting time (10.4±7.6 weeks), while South Africa had the shortest waiting time (4.0±3.0 weeks). The scarcity of radiotherapy machines and human resources in Africa is apparent, potentially leading to prolonged waiting times for patients before treatment initiation, particularly given the high incidence of more than 20 newly diagnosed patients per month in most countries. This survey underscores the urgent need to address identified gaps to improve access to both radiotherapy and human resources across the continent.
Renal outcomes with sodium-glucose cotransporters 2 inhibitors in Patients with Type 2 Diabetes Mellitus with Chronic Kidney Disease Stages 3b-4.
Authors: Kawalit Issa , Al-Omari Abdulraqeeb , Kalaji Zeina , Al-Tirawi Asad , Eltwal Muhand , El-Khatib Abbas
Published: December 2024

Introduction: Randomized clinical trials have shown that sodium-glucose cotransporter 2 (SGLT2) inhibitors significantly reduce renal events in patients with type 2 diabetes mellitus (T2DM) at high risk for cardiovascular disease. However, these trials included only a small number of patients with moderate-to-severe chronic kidney disease (CKD), leaving the renoprotective effects of SGLT2 inhibitors in T2DM patients and impaired renal function unclear.

Methods: This retrospective study evaluated the effects of SGLT2 inhibitors on kidney function in T2DM patients with CKD stages 3b-4 with estimated glomerular filtration rate (eGFR) 15-45 mL/min/1.73 m². Conducted by a single nephrology group across two medical centers, the study included 175 T2DM patients who initiated SGLT2 inhibitor therapy and continued treatment for at least one year. The primary outcomes were changes in eGFR and urinary protein excretion over a one-year period.

Results: After one year of SGLT2 inhibitor therapy, the median eGFR showed no significant change from baseline. However, the annual decline in eGFR significantly improved, and urinary protein excretion decreased significantly. Despite these positive renal outcomes, HbA1c reduction was not significant.

Conclusion: This study demonstrated that SGLT2 inhibitors offer renoprotective benefits in T2DM patients with moderate-to-severe CKD by improving the annual decline in eGFR and reducing urinary protein excretion. Further prospective clinical studies are required to assess the long-term effects of SGLT2 inhibitors on glycemic control and renal function in this patient population.
Transforming Breast Cancer Care: Empowering Patient’s Quality of Life through Resilience
Authors: Sonalika Soumya , Rout Sasmita , Pradhan Debasis , Lenka Shivaji , Pattanayak Anasuya
Published: December 2024

Introduction: Although breast cancer remains one of the biggest health challenges all over the world, yet, comprehensive management is equally important in considering the overall needs of the breast cancer patients for the enhancement of quality of life. It is through some review innovations, issues, and opportunities in breast cancer care with special emphasis on empowering strategies based on resilience building that this review was triggered.

Methods: Through this, an extensive literature review was conducted on the innovations in the treatment and care of patients with breast cancer, especially in areas of primary focus such as psychosocial support, integrative therapies, digital health tools, and survivorship programs. Community resources and support services have also been analyzed, including emerging areas of empowerment for patients.

Results: Innovative approaches to breast cancer care have evolved beyond the medical dimension, adding aspects of integration in the practice of oncology & resilience training addressing emotional well-being. With telehealth and other digital solutions, patients will have access to support services. Opportunities include extending the reach of peer support networks, virtual care, and patient education etc., while barriers to social and emotional care include financial, emotional fatigue, and access to care.

Conclusion: The changing landscape of breast cancer care is evenmore concerned with not only the treatment of the disease but with the treatment of the patient. Medical care integrated with non-medical needs can help the healthcare provider ensure patients survive but live through as well as beyond breast cancer
A Measure for Evaluating Basic Psychological Interviewing Skills
Authors: Cash Ralph , Gray Sarah , Worton Shannon , Newman Alyssa
Published: December 2024

Traditionally, graduate programs in psychology have relied upon applied practicum experiences and supervisor evaluations to establish a student’s clinical competence. However, guidelines established by the American Psychological Association (APA) Standards of Accreditation (SoA) for Health Service Psychology require that programs accredited by the APA assess every graduate student in vivo or via recording each time an evaluation is conducted (usually each grading period). There are currently no published, standardized measures in applied psychology to gather most of these data in a reliable and valid fashion.

The purpose of the current study was to develop and to take steps toward standardization of an empirically validated measure for use within graduate training in psychology. The Skills in Psychological Interviewing: Clinical Evaluation Scales (SPICES) was developed in response to the need for standardized methods of evaluating psychology students’ skills across the nine profession-wide competency areas, as identified by the SoA. Evaluation of the SPICES measure provided empirical support for its reliability, validity, and usefulness in graduate training, lending support for use of the measure as one method to evaluate student performance across the APA Competency Benchmarks in Professional Psychology. Importantly, the measure is congruent with the SoA’s profession-wide competency areas and provides programs with a framework for helping to evaluate each student’s readiness for practicum at various levels as well as internship.
Intertriginous Dermatitis
Authors: Black Joyce
Published: December 2024

Moisture associated skin damage (MASD) is a label for a spectrum of skin injury from 4 sources: exposure to urine and stool (incontinence associated dermatitis), sweat (intertriginous dermatitis), wound exudate (periwound dermatitis) and stoma exudate (peristomal dermatitis). Intertriginous dermatitis (ITD), also known as intertrigo, is a common inflammatory disorder that occurs due to skin-on-skin friction in the skin folds, because of moisture becoming trapped due to poor air circulation. 1 Intertrigo's Latin translation, inter (between) and terere (to rub) helps explain the pathophysiology of the condition. The 11th revision of the World Health Organization's (WHO) International Classification of Diseases (ICD-11) now contains codes for the separate forms of MASD within the EK02 irritant contact dermatitis section. 2

This article provides a general overview of intertriginous dermatitis and outlines its etiology, pathophysiology and offers management techniques. ITD does not have a strong evidence base for practice therefore, practitioners often have to rely on experience. 1,3
ENDOMETRIOSIS-RELATED OVARIAN CARCINOGENESIS: UNRAVELLING THE ROOTS OF A LONG-STANDING ENIGMA
Authors: Larrain Demetrio , Barrena Nicanor
Published: December 2024

Endometriosis is a gynecologic disease in which ectopic endometrial tissue causes both chronic pelvic pain and infertility. Likewise, this entity has been linked with the development of certain types of epithelial ovarian cancer. The mechanisms underlying this association have remained largely elusive yet recent advances in terms of identifying histologically well-defined precursor lesions as well as key molecular and genetic abnormalities involved in the endometriosis malignant transformation have dramatically improved the understanding of this clinical conundrum.
Status and Future Management of Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus Infections
Authors: Steletou Evangelia , Whitley Richard
Published: December 2024

Congenital cytomegalovirus (CMV) and herpes simplex virus (HSV) infections are among the most common viral infections of the newborn in the developed world. CMV infections can cause sensorineural hearing loss, and both CMV and HSV infections can lead to impaired neurodevelopment. Diagnostic and treatment efforts have been investigated for the past 45 years. With the development of polymerase chain reaction (PCR) for diagnosis and its quantitation as well as studies of the pharmacokinetics and pharmacodynamics of ganciclovir/valganciclovir (CMV) and acyclovir (HSV), significant improvement in outcome has been achieved. For example, studies utilizing ganciclovir and valganciclovir demonstrate improved hearing and Bailey Developmental scores; however, therapy requires six months of treatment with valganciclovir. With neonatal HSV infections, high-dose acyclovir decreases mortality for two classifications of disease - encephalitis and disseminated multiorgan infection. Like congenital CMV infections, neonatal HSV requires long-term suppressive therapy following a course of IV acyclovir. Regardless, outcome for both diseases is unsatisfactory, and improved treatment approaches must be developed.

The current review addresses these two members of the Herpesviridae family: the diseases they cause in the newborn, the current shortcomings and a consideration of future needs. Both viruses establish latency and are reactivated throughout an individual’s lifetime, ergo eradication at the present is impossible. The discussion is limited to these two life-threatening diseases. The successful lessons learned from combination therapies of human immunodeficiency virus and hepatitis C virus infections must be applied to these diseases. If improvement can be documented, it will have direct implications for managing diseases caused by both viruses in older individuals. It is the aim of the review to provide the reader with knowledge of the field, providing a reference to future needs and opportunities.
The benefits of a modified Online Professional Learning Community during COVID-19
Authors: Savignano Dr. Mark , Page Dr. Scott , Holbrook John
Published: December 2024

The COVID-19 pandemic necessitated a rapid shift to remote learning, revealing the need for effective online educational strategies. This article examines the challenges and opportunities associated with this transition, particularly through the lens of Professional Learning Communities (PLCs) within a Hybrid course at Minnesota State University, Mankato. Utilizing Garrison's Community of Inquiry framework, the study assessed how PLCs fostered social, cognitive, and teaching presence among pre-service teachers. The findings suggest that PLCs can be an effective model for promoting community and peer support in online learning, yet emphasize the importance of addressing engagement issues. This study offers insights into improving educational practices and fostering meaningful interactions in virtual learning settings, with implications for broader applications of PLCs across various disciplines.
Utilizing Socio-Economic Indicators and Artificial Neural Networks to Predict COVID-19 Spread in Canadian Health Regions
Authors: Wickramasinghe Lahiru , Jain Aditya
Published: December 2024

This study explores how well Artificial Neural Networks (ANNs) can predict the spread of COVID-19 across Canadian health regions, focusing on the impact of socio-economic factors. By examining a wide range of demographic, economic, and social indicators, we identify which factors play the biggest role in accurately forecasting the pandemic’s spread. The trained ANN model underscores the critical role of urbanization, population density, and social behaviors in densely populated regions, such as Toronto and Montreal, where transmission rates were higher. Conversely, remote regions like the Keewatin Yatthé and Labrador-Grenfell Health Authorities saw lower transmission due to geographic isolation and community-based controls. Additionally, the study highlights disparities in healthcare infrastructure, especially in ICU bed availability, which were more pronounced in urban areas. Vaccination rates were also identified as key in controlling the spread, with proactive public health efforts leading to higher rates in regions like the Northwest Territories. Our findings show that these socio-economic factors vary in importance from one region to another, offering valuable insights for public health planning. These findings provide practical advice for improving how resources are allocated and how public health strategies are developed, emphasizing the need to consider socio-economic differences in pandemic forecasting. This approach aims to help policymakers and health officials respond more effectively to current and future public health challenges.
Histological Evaluation of Urachal remnants
Authors: Baba Kyoko , Ito Risako , Ando Yuki , Kuwabara Ami , Wato Junpei , Takeda Akira
Published: December 2024

Introduction: Urachal remnant disease occurs when the fetal urachus fails to close after birth. We perform surgical excision of umbilical sinus-type urachal remnants, aiming for complete resection to prevent residual urachal epithelium, which may become a source for urachal carcinoma. This study reports immunohistochemical findings from surgical specimens to assess epithelial involvement and inform resection strategies.

Materials and Methods: We reviewed cases of urachal remnant excision performed over one year at the Department of Plastic Surgery, Kitasato University Medical Center. Patient characteristics, including age, sex, symptoms, MRI findings, length of resected cord-like structures, and histopathological results, were examined. Histological evaluation included hematoxylin and eosin (H&E) staining and immunohistochemistry. Markers used were keratin AE1/AE3 and epithelial membrane antigen (EMA) for epithelial cells, factor VIII for vascular endothelium, α-smooth muscle actin (αSMA) for smooth muscle cells, and S-100 protein for nerve fibers.

Results: Five patients (3 males, 2 females; age range 16–69 years) underwent surgery for urachal remnant disease. All presented with peri-umbilical inflammation. Preoperative MRI identified tubular structures ranging from 1.2 to 6.4 cm, while the resected cord-like structures measured 6 to 11 cm. The resected specimens were 3 to 5.2 cm longer than the tubular structures seen on MRI, and no tubular structures were observed at the surgical margins. Three cases showed clear tubular structures on H&E staining, all of which were positive for keratin AE1/AE3 and EMA, with keratin AE1/AE3 showing stronger staining. The remaining two cases, without clear tubular structures, were negative for keratin AE1/AE3 and EMA. αSMA was positive in all cases, while no significant findings were noted with factor VIII or S-100 protein.

Discussion: The ideal resection range for urachal remnants remains unclear. In this study, resecting at least 2 cm beyond inflammatory signs during surgery, combined with intraoperative confirmation of the absence of tubular structures, resulted in complete excision. Immunohistochemical staining, particularly keratin AE1/AE3, was valuable in identifying residual epithelial components, while αSMA was useful for assessing remnant structures.
The impact of the Covid-19 pandemic on young and elderly psychological well-being: the role of social and cultural participation. A cross-sectional exploratory study
Authors: Blessi Giorgio , Grossi Enzo , Colleoni Matteo , Garbato Francesca , Colombo Paolo
Published: December 2024

Background: In the last 20 years a growing literature has highlighted the role of social and cultural activities in fostering individual and community well-being. The Covid-19 pandemic had an important impact on individuals and communities given the lockdown policies enacted, causing the unexpected and forced abandonment of these activities.

Aims: The present work investigates the impact caused by Covid-19 and the consequent suspension of all associated social and cultural opportunities for young and elderly individual subjective well-being.

Methods: We undertook a cross-sectional survey in January 2020 (t1, pre-pandemic), and a second carried out one year later in February 2021 (t2 post-pandemic), on a sample of individuals from 18 to 34 years old and >64 years old in a town lying within the metropolitan area of Milan (Italy). We employed the PGWBI - Psychological General Well-Being Index to assess the psychological aspect and to measure the influence of the social and cultural dimensions. P-value, Cohen g and Pearson r statistical techniques were employed.

Results: Results show that the psychological well-being increased for the sample of young people from 67.82 to 76.49, and decreased for the >64 sample from 59.84 to 57.23. An analysis of the correlation shows that social and cultural participation played a role in promoting the young’s well-being and reduced the impact of the pandemic in those >64.

Conclusion: Some socio-demographic variables seem to be affected by the pandemic in both cohorts. The contribution of social and cultural activities appears relevant, thus providing elements for further investigation in the field of the relationship between these dimensions and individual subjective well-being.
Resolution of Refractory COVID-19 Vaccine-Induced Myopericarditis with Adjunctive Rapamycin
Authors: Hulscher Nicolas , Vickery Alexander , McCullough Peter A.
Published: December 2024

COVID-19 vaccine-induced myopericarditis is now commonly encountered in clinical practice. The mainstay of clinical management involves vaccine Spike protein detoxification and colchicine for 12 months or longer. Herein, we present a case of a previously healthy 23-year-old male with autism spectrum disorder who developed COVID-19 vaccine-induced myopericarditis and class II heart failure. He was treated with Spike detoxification, which is the combined use of over-the-counter nattokinase, bromelain, and curcumin, in addition to colchicine. While transient heart failure resolved, his chest discomfort persisted and at times was debilitating. Serial electrocardiograms indicated persistent global ST segment elevation. We describe the successful addition of off-label oral rapamycin to arrest inflammatory processes, extirpate ST elevation, and significantly improve quality of life. We summarize existing research that provided a rationale for the use of rapamycin. Concisely, these include targeting autophagy, mRNA translation, and immune activity modulation. We propose that mTOR inhibitors should be investigated as a potential disease-modifying interim treatment for COVID-19 vaccine induced cardiac injury.
Private Higher Education Intention in Adopting Blockchain Technology on Accounting Information System (AIS)
Authors: Amalia Rizka , Pratolo Suryo
Published: December 2024

Research aims: This study was conducted with the aim of testing and obtaining empirical evidence regarding the intention of Private Higher Education Institutions (HEIs) to adopt blockchain in accounting information systems (AIS) using the Unified Theory of Acceptance and Use of Technology (UTAUT) model.
Design/Methodology/Approach: The sample of this research is Private HEIs in Java that have been accredited "Very Good" and "Excellent," and the respondents representing the sample of this research are the Head of Private HEIs in the Finance Sector, and the Head of the Financial Agency/Institution/Bureau of Private HEIs selected through purposive sampling technique. Data were collected using a questionnaire and analyzed using the Partial Least Square method.
Research findings: The results indicate that performance expectancy, effort expectancy, and social influence have a positive impact on the intention of private HEIs to use blockchain in AIS.
Theoretical contribution/Originality: This research provides a theoretical contribution by confirming the UTAUT theory and expanding the literature related to the adoption of blockchain in AIS in private HEIs.
Practitioner/Policy implication: The findings of this research can serve as a basis for policy-making regarding the implementation of blockchain technology in the private HEIs education sector and offer valuable insights for private HEIs to prepare for the implementation of blockchain technology in AIS in the education sector.
Research limitation/Implication: The sample was limited to private higher education in Java, making the results not generalizable to a broader context.
Management of extra palatal canal in a maxillary molar: A case report
Authors: Chopra Krish
Published: December 2024

The occurrence of anatomical complexities during Root Canal Treatment often poses a great challenge in terms of management. Such variations, if not treated meticulously could lead to catastrophic failure of the adopted treatment approach. A thorough pre-operative evaluation has been attributed to the prevention of ‘missed’ canals. The persistence of microbiota within these ‘missed’ canals could be a causative factor for post treatment disease. The maxillary molar typically presents with 4 canals: Two mesiobuccal (MB and MB2), one distobuccal (DB) and one palatal (P). The following case report describes an endodontic intervention for a maxillary molar with the presence of an ‘extra’ palatal canal.
The Suape Museum
Authors: Vailati Alex , Morim Júlia
Published: December 2024

The discovery of a collection of Super 8 films recorded in the 1970s documenting the construction of the Suape Port in the state of Pernambuco, Brazil, is the focus of this article. The films were accidentally found during community-focused extension projects aimed at the local community affected by an oil spill. The need to preserve the content of the collection, which was initially meant to be forgotten, became important. The digitization of the images and the creation of an experimental museum were proposed to make these films accessible to the public. The Suape Museum emerges as a counter-narrative, seeking to recover and reinterpret these images within a context of reflections on the present and future of the region. For the community affected by the transformations and impacts of port construction, the collection brings up traumatic memories. Through a collaborative approach to musealization, the aim is to produce new meanings from these images.
Corpus film: el monstruo del Chaco
Authors: Passarelli Franco , Cantero Emanuel , Martina Francisco
Published: December 2024

El trabajo es un ejercicio reflexivo que da cuenta de las diversas etapas creativas —investiga- ción antropológica inicial, montaje y exhibición— de la videoinstalación Corpus film, inaugurada en la ciudad de Resistencia (Chaco, Argentina) en 2022. Se trata de explorar el proceso cola- borativo entre el artista experimental y el antropólogo audiovisual (creadores de la obra), con el objetivo de observar cómo la práctica curatorial puede convertirse en una estrategia para la investigación etnográfica y artística.
El vicio de incongruencia en laudos extranjeros, inejecutabilidad por violación al orden público ecuatoriano
Authors: Eduardo Narváez Luis , Belén Merchán María
Published: December 2024

Los laudos emitidos en el contexto de un arbitraje internacional pueden en ciertos casos adolecer de vicio de incongruencia. Bajo la mirada de la lex arbitri aplicable a cada caso en particular, estos laudos, en virtud de la interpretación restrictiva que se debe dar a las causales de nulidad y el principio de trascendencia, podrán o no ser anulados en la sede del arbitraje. No obstante, en virtud de la aplicación del artículo V de la Convención de Nueva York, el vicio de incongruencia de un laudo arbitral podría ser causal para la oposición al reconocimiento y ejecución del laudo en el Ecuador. Esto, en virtud de que el principio de congruencia es parte de los derechos de Tutela Arbitral Efectiva y Debido proceso, garantías constitucionales básicas en el Ecuador que forman parte del orden público ecuatoriano.
Borders of Memory, Memory of Borders: The Annam Bronze Pillars
Authors: Guida Donatella
Published: December 2024

This paper focuses on the bronze pillars allegedly erected by the Chinese general Ma Yuan in the first century CE that were still supposed to mark the frontier between Ming China and Vietnam. Through a close reading of several sources, the paper demonstrates that across the centuries many contradictory explanations were given by Chinese and Vietnamese histories, suggesting that the columns were a symbol rather than an actual border for both populations; a symbol to signal a divide and a clear hierarchy but also a way to underline a common heritage and culture, whose memory or imagination lasted for centuries.
Processo de crioconcentração na indústria de alimentos: uma revisão da técnia e suas aplicações
Authors: Oliveira de Souto Valter , Martins Campos Fábio , Sperotto Gabriela , Lazzarotto Marcelo
Published: December 2024

A crioconcentração, conhecida por sua eficácia, simplicidade e baixo custo, tem despertado crescente interesse na indústria de alimentos. Este trabalho tem como objetivo apresentar uma revisão da técnica de crioconcentração e suas diversas aplicações. A técnica já demonstrou sua eficácia na preservação de compostos bioativos em sucos de frutas e vinhos, assim como na produção de concentrados de suco de maçã, laranja, uva e chá verde. À medida que a crioconcentração continua a evoluir, seu potencial como uma abordagem promissora para o desenvolvimento de produtos alimentícios de alto valor agregado torna-se cada vez mais evidente. Com a capacidade de preservar compostos bioativos, melhorar a qualidade nutricional e intensificar a concentração de sabores, a crioconcentração está desempenhando um papel significativo no cenário da indústria de alimentos. Sua simplicidade e custos acessíveis também a tornam uma opção viável, inclusive para pequenos e médios produtores. Assim, a crioconcentração não apenas contribui para a produção de alimentos de alta qualidade, mas também se alinha com princípios de sustentabilidade e economia circular, ao aproveitar ao máximo matérias-primas regionais e subprodutos de processos industriais.
As brincadeiras e os tipos de brincar: A perspectiva de crianças e seus pais considerando a pandemia de COVID-19
Authors: Flores Malvera Miriã , Bolzan de Campos Camila , Paris Feijó Luan
Published: December 2024

O avanço acelerado das tecnologias tem proporcionado maior acessibilidade às crianças e cada vez mais elas têm sido parte do cenário da indústria tecnológica. Considerando o exposto, o presente estudo tem como objetivo identificar se há relação entre o uso de telas e os tipos de brincadeiras. Trata-se de uma pesquisa qualitativa, descritiva e exploratória, com crianças de uma turma de 2º ano, na faixa etária de sete anos, de uma escola da rede municipal de Canoas. A entrevista também foi conduzida com os responsáveis legais das crianças, utilizando instrumentos como entrevistas semiestruturadas e desenhos. Os dados foram analisados utilizando a técnica de análise temática. Os resultados demonstraram que as crianças preferem os brinquedos analógicos, e a escolha das brincadeiras, em sua maioria, tem finalidades psicológicas, e optam por realizá-las em ambientes abertos. Foi possível constatar também que, embora as crianças tenham preferência por brincadeiras analógicas, a facilidade e comodidade as direcionam para os meios tecnológicos. Isso significa que há uma expectativa de brincar que difere do que é propriamente realizado, demonstrando que as crianças não têm sido ouvidas pelos familiares, o que pode sugerir dificuldades no entendimento dos familiares em relação às necessidades das crianças.
Uva e bebidas derivadas da uva: uma revisão das características químicas, dos compostos bioativos e aplicações de tecnologias emergentes
Authors: Oliveira de Souto Valter , Martins Campos Fábio , Sperotto Gabriela , De Assis Regis Auriana , Marinho de Almeida Joellington , Lazzarotto Marcelo
Published: December 2024

A uva é uma fruta cultivada desde a antiguidade e desempenha um papel crucial na produção de diversas bebidas. O objetivo deste artigo é revisar as características químicas das uvas, os compostos bioativos e as aplicações de tecnologias emergentes. Foi realizada uma busca na literatura científica, utilizando termos específicos e combinações de palavras-chave. Foram selecionados 30 trabalhos relevantes, cujas informações foram organizadas em dois tópicos: características químicas e compostos bioativos das uvas; e a aplicação de tecnologias emergentes no processamento de bebidas à base de uva. As uvas, ricas em açúcares, ácidos orgânicos e compostos fenólicos, são essenciais para a qualidade sensorial das bebidas. Compostos bioativos, como polifenóis e resveratrol, são destacados por seus benefícios à saúde, incluindo propriedades antioxidantes e cardioprotetoras. Tecnologias emergentes, como ultrassonicação e alta pressão hidrostática, têm otimizado a extração de compostos benéficos e melhorado a estabilidade dos produtos. A inovação no setor vitivinícola é crucial para atender às demandas dos consumidores. Esta revisão oferece uma visão sobre o potencial das uvas e suas bebidas derivadas, integrando conhecimentos químicos e tecnológicos para a melhoria contínua do setor.
Modes of inhibition of cysteine proteases.
Authors: Rzychon Malgorzata , Chmiel Dorota , Stec-Niemczyk Justyna
Published: December 2024

Cysteine proteases are involved in many physiological processes and their hyperactivity may lead to severe diseases. Nature has developed various strategies to protect cells and whole organisms against undesired proteolysis. One of them is the control of proteolytic activity by inhibition. This paper presents the mechanisms underlying the action of proteinaceous inhibitors of cysteine proteinases and covers propeptides binding backwards relative to the substrate or distorting the protease catalytic centre similarly to serpins, the p35 protein binding covalently to the enzyme, and cystatins that are exosite binding inhibitors. The paper also discusses tyropins and chagasins that, although unrelated to cystatins, inhibit cysteine proteinases by a similar mechanism, as well as inhibitors of the apoptosis protein family that bind in a direction opposite to that of the substrate, similarly to profragments. Special attention is given to staphostatins, a novel family of inhibitors acting in an unusual manner.
Comparison between the Polish population and European populations on the basis of mitochondrial morphs and haplogroups.
Authors: Piechota Janusz , Tońska Katarzyna , Nowak Magda , Kabzińska Dagmara , Lorenc Anna , Bartnik Ewa
Published: December 2024

Polymorphisms in mitochondrial DNA (mtDNA) were analyzed in 152 samples from the Polish population using restriction enzymes AvaI, BamHI, HaeII, HpaI and PstI. Additionally, each sample was classified into the appropriate haplogroup. When required, appropriate fragments were sequenced to establish the exact polymorphic sites. We found one new morph for PstI and six new morphs for AvaII. Some detected morphs have previously been described as population specific morphs in different regions of the world. All polymorphisms were classified into 31 different haplotypes. 21 of them were detected in single individuals. The Polish population was compared with other populations from different regions. Moreover, we have obtained evidence for mutation hot spots in the mtDNA coding region. Our results indicate that AvaII morph and haplogroup composition of the Polish population is similar to other European populations and has a distribution typical for this part of the world. However, statistically significant differences in haplogroup composition were found between the Polish population and Italian and Finnish populations.
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin.
Authors: Panoutsopoulos Georgios I , Beedham Christine
Published: December 2024

The enzymes aldehyde oxidase and xanthine oxidase catalyze the oxidation of a wide range of N-heterocycles and aldehydes. These enzymes are widely known for their role in the metabolism of N-heterocyclic xenobiotics where they provide a protective barrier by aiding in the detoxification of ingested nitrogen-containing heterocycles. Isovanillin has been shown to inhibit the metabolism of aromatic aldehydes by aldehyde oxidase, but its inhibition towards the heterocyclic compounds has not been studied. The present investigation examines the oxidation of phthalazine in the absence and in the presence of the inhibitor isovanillin by partially purified aldehyde oxidase from guinea pig liver. In addition, the interaction of phthalazine with freshly prepared guinea pig liver slices, both in the absence and presence of specific inhibitors of several liver oxidizing enzymes, was investigated. ldehyde oxidase rapidly converted phthalazine into 1-phthalazinone, which was completely inhibited in the presence of isovanillin (a specific inhibitor of aldehyde oxidase). In freshly prepared liver slices, phthalazine was also rapidly converted to 1-phthalazinone. The formation of 1-phthalazinone was completely inhibited by isovanillin, whereas disulfiram (a specific inhibitor of aldehyde dehydrogenase) only inhibited 1-phthalazinone formation by 24% and allopurinol (a specific inhibitor of xanthine oxidase) had little effect. Therefore, isovanillin has been proved as an inhibitor of the metabolism of heterocyclic substrates, such as phthalazine, by guinea pig liver aldehyde oxidase, since it had not been tested before. Thus it would appear from the inhibitor results that aldehyde oxidase is the predominant enzyme in the oxidation of phthalazine to 1-phthalazinone in freshly prepared guinea pig liver slices, whereas xanthine oxidase only contributes to a small extent and aldehyde dehydrogenase does not take any part.
Benzodiazepine binding to mitochondrial membranes of the amoeba Acanthamoeba castellanii and the yeast Saccharomyces cerevisiae.
Authors: Slocinska Malgorzata , Szewczyk Adam , Hryniewiecka Lilla , Kmita Hanna
Published: December 2024

Benzodiazepine binding sites were studied in mitochondria of unicellular eukaryotes, the amoeba Acathamoeba castellanii and the yeast Saccharomyces cerevisiae, and also in rat liver mitochondria as a control. For that purpose we applied Ro5-4864, a well-known ligand of the mitochondrial benzodiazepine receptor (MBR) present in mammalian mitochondria. The levels of specific [(3)H]Ro5-4864 binding, the dissociation constant (K(D)) and the number of [(3)H]Ro5-4864 binding sites (B(max)) determined for fractions of the studied mitochondria indicate the presence of specific [(3)H]Ro5-4864 binding sites in the outer membrane of yeast and amoeba mitochondria as well as in yeast mitoplasts. Thus, A. castellanii and S. cerevisiae mitochondria, like rat liver mitochondria, contain proteins able to bind specifically [(3)H]Ro5-4864. Labeling of amoeba, yeast and rat liver mitochondria with [(3)H]Ro5-4864 revealed proteins identified as the voltage dependent anion selective channel (VDAC) in the outer membrane and adenine nucleotide translocase (ANT) in the inner membrane. Therefore, the specific MBR ligand binding is not confined only to mammalian mitochondria and is more widespread within the eukaryotic world. However, it can not be excluded that MBR ligand binding sites are exploited efficiently only by higher multicellular eukaryotes. Nevertheless, the MBR ligand binding sites in mitochondria of lower eukaryotes can be applied as useful models in studies on mammalian MBR.