bluuebunny/crossref_metadata_2025 huggingface dataset:
Hygienic Perspectives of Wood in Healthcare Buildings
Authors: Munir Muhammad Tanveer , Pailhoriès Hélène , Aviat Florence , Lepelletier Didier , Pape Patrice Le , Dubreil Laurence , Irle Mark , Buchner Julia , Eveillard Matthieu , Federighi Michel , Belloncle Christophe
Published: May 2021

Wood materials are being adopted as nature-based architectural themes inside the healthcare buildings. Concern is raised that the organic and porous character of wood might support microbial survival. Therefore, this review discusses the hygienic properties of wood including the antimicrobial potential and its cleanability in comparison to smooth surface materials. In general, wood has antimicrobial properties owing to its chemical composition and physical structure. However, the hygienic potential of wood is influenced by the type of wood, age of wood, the cleaning method, surface treatment, and its moisture content. This information is intended to guide decision-makers regarding the use of wood in hygienically sensitive places and researchers to help them identify the variables for better utilizing the hygienic potential of this material.
Importance of Local Data and Resource Allocation for Effective Successful Public Health Interventions to Reduce COVID-19 Transmission: Commentary on COVID-19 Medical Vulnerability Indicators: A Predictive Local Data Model for Equity in Public Health Decision-Making
Authors: Sondik Edward , Fielding Jonathan
Published: May 2021

The article, COVID-19 Medical Vulnerability Indicators: Predictive Local Data Model for Equity in Public Health Decision-Making (2021), is an important contribution to identifying and prioritizing the needs of Los Angeles’ public healthcare in responding to the COVID-19 pandemic crisis [...]
Crisis Preparedness of Healthcare Manufacturing Firms during the COVID-19 Outbreak: Digitalization and Servitization
Authors: Zhang Jingsi , Qi Liangqun
Published: May 2021

For healthcare manufacturing firms, creating a crisis-prepared product and service portfolio and operational processes is essential for their long-term prosperity. In this paper, we examine how healthcare manufacturing firms cope with the operational disruptions and opportunities associated with the COVID-19 pandemic. We highlight the central role of organizational resilience and examine whether servitization and digitalization can improve the organizational resilience of healthcare manufacturing firms. On the basis of the organizational information processing theory, we suggest that servitization and digitalization can improve the stability and flexibility of operations, which make healthcare manufacturing firms more resilient to the COVID-19 pandemic. The hypotheses were tested using survey data from 163 manufacturing firms located in China. The results indicate that both servitization and digitalization improve the organizational resilience of healthcare manufacturing firms, leading to higher firm growth during the COVID-19 pandemic. Moreover, organizational resilience mediates the impacts of servitization and digitalization on firm growth. Environmental dynamism strengthens the relationship between digitalization and organizational resilience. This study offers new insights for healthcare manufacturing firms to prepare for crisis events and achieve sustainable development in a highly competitive environment.
Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study
Authors: Solans Marta , Fernández-Barrés Sílvia , Romaguera Dora , Benavente Yolanda , Marcos-Gragera Rafael , Gracia-Lavedan Esther , Costas Laura , Robles Claudia , Gonzalez-Barca Eva , de la Banda Esmeralda , Alonso Esther , Aymerich Marta , Campo Elias , Llorca Javier , Fernández-Tardón Guillermo , Olmedo-Requena Rocío , Gimeno Eva , Castaño-Vinyals Gemma , Aragonés Nuria , Kogevinas Manolis , Pollán Marina , de Sanjose Silvia , Amiano Pilar , Casabonne Delphine
Published: May 2021

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. Its etiology is largely unknown but increasing incidence rates observed worldwide suggest that lifestyle and environmental factors such as diet might play a role in the development of CLL. Hence, we hypothesized that the consumption of ultra-processed food and drinks (UPF) might be associated with CLL. Data from a Spanish population-based case-control study (MCC-Spain study) including 230 CLL cases (recruited within three years of diagnosis) and 1634 population-based controls were used. The usual diet during the previous year was collected through a validated food frequency questionnaire and food and drink consumption was categorized using the NOVA classification scheme. Logistic regression models adjusted for potential confounders were used. Overall, no association was reported between the consumption of UPF and CLL cases (OR per each 10% increase of the relative contribution of UPF to total dietary intake = 1.09 (95% CI: 0.94; 1.25)), independently of the Rai stage at diagnosis. However, when analyses were restricted to cases diagnosed within <1 year (incident), each 10% increment in the consumption of UPF was associated with a 22% higher odds ratio of CLL (95% CI: 1.02, 1.47) suggesting that the overall results might be affected by the inclusion of prevalent cases, who might have changed their dietary habits after cancer diagnosis. Given the low number of cases in the subgroup analyses and multiple tests performed, chance findings cannot totally be ruled out. Nonetheless, positive associations found in CLL incident cases merit further research, ideally in well-powered studies with a prospective design.
Radon in Schools: A Review of Radon Testing Efforts in Canadian Schools
Authors: Shergill Sandy , Forsman-Phillips Lindsay , Nicol Anne-Marie
Published: May 2021

Radon, a known carcinogen, becomes a health risk when it accumulates inside buildings. Exposure is of particular concern for children, as their longer life expectancy increases their lifetime risk of developing cancer. In 2016, 5.5 million students were enrolled in Canadian elementary and secondary schools. With no national policy on radon testing in schools, children may be at risk from radon exposure while attending school and school-based programs. This study explored radon testing efforts in publicly funded Canadian schools and summarizes where testing programs have occurred. Radon testing in schools was identified through a systematic qualitative enquiry, surveying members from different levels of government (health and education) and other stakeholders (school boards, research experts, among others). Overall, this research found that approaches to radon testing varied considerably by province and region. Responsibility for radon testing in schools was often deferred between government, school boards, building managers and construction parties. Transparency around radon testing, including which schools had been tested and whether radon levels had been mitigated, also emerged as an issue. Radon testing of schools across Canada, including mitigation and clear communication strategies, needs to improve to ensure a healthy indoor environment for staff and students.
E-Cigarette Use in Young Adult Never Cigarette Smokers with Disabilities: Results from the Behavioral Risk Factor Surveillance System Survey
Authors: Atuegwu Nkiruka C. , Litt Mark D. , Krishnan-Sarin Suchitra , Laubenbacher Reinhard C. , Perez Mario F. , Mortensen Eric M.
Published: May 2021

Young adult never cigarette smokers with disabilities may be at particular risk for adopting e-cigarettes, but little attention has been paid to these people. This study examines the associations between different types of disability and e-cigarette use in this population. Young adult never-smokers from the 2016–2017 Behavioral Risk Factor Surveillance System (BRFSS) survey who were either never or current e-cigarette users (n = 79,177) were selected for the analysis. The Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was used to select confounders for multivariable logistic regression models. Multivariable logistic regression models were used to determine the associations between current e-cigarette use and different types of disability after incorporating BRFSS survey design and adjusting for confounders. Young adult never-smokers who reported any disability had increased odds (OR 1.44, 95% CI 1.18–1.76) of e-cigarette use compared to those who reported no disability. Young adult never-smokers who reported self-care, cognitive, vision, and independent living disabilities had higher odds of e-cigarette use compared to those who reported no disability. There was no statistically significant difference in the odds of e-cigarette use for those reporting hearing and mobility disabilities compared to those who reported no disability. This study highlights the need for increased public education and cessation programs for this population.
An Evaluation of Two Systems for the Management of the Microbiological Quality of Water in Dental Unit Waterlines: Hygowater® and IGN Calbénium®
Authors: Offner Damien , Musset Anne-Marie
Published: May 2021

Water in dental unit waterlines (DUWL) represents a risk for vulnerable patients if its microbiological quality is not controlled. The aim of this prospective study was to evaluate two systems for its management under real conditions: Hygowater® and IGN Calbenium®. Samples of the output water of DUWL were obtained for 5 previously contaminated units connected to Hygowater®, and 5 non-contaminated units connected to IGN Calbenium®, which was already effective for more than 1 year, as a control group. Samples were regularly collected up to 6 months after the implementation of Hygowater®, and were then cultured and analyzed. With IGN Calbenium®, except for a technical problem and a sample result in one unit at 6 months (Heterotrophic Plate Count (HPC) at 37 °C of 66 colony forming units (cfu)/mL), the results showed an absence of contamination. Hygowater® took a couple of weeks to be effective on initially contaminated DUWL (over 200 cfu/mL for all the units), then showed its efficacy for 2 months (HPC at 37 °C with a mean of 40.2 ufc/mL, and HPC at 22 °C with a mean of 0.2 ufc/mL). At 6 months, results were satisfactory for HPC at 22 °C (mean of 12 ufc/mL), but HPC at 37 °C gave non-satisfactory results for 4 of the 5 units (mean of 92.2 ufc/mL). Both systems have an effect on the microbiological quality of DUWL. IGN Calbenium® appears to be more reliable on a long-term basis.
The Dark Triad of Personality’s Relationship with Compliance towards COVID-19 Pandemic Recommendations along with Anxiety and Depressive Symptoms in Polish Citizens
Authors: Gogola Anna M. , Dębski Paweł , Goryczka Agnieszka , Gorczyca Piotr , Piegza Magdalena
Published: May 2021

The outbreak of the COVID-19 pandemic forced everyone to comply with rules of a sanitary regime and social distancing on a daily basis. The aim of our research was to assess the differences in the levels of Dark Triad traits between people who obeyed and disobeyed the pandemic restrictions. Additionally, we considered the possible correlation between the Dark Triad and the intensity of symptoms of depression and anxiety. A total of 604 Polish participants, whose average age was 28.95 ± 11.27 years, completed an online survey which measured Dark Triad traits using the Polish version of the Dirty Dozen test. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). The results revealed a possible relationship between personality traits and compliance with pandemic restrictions. Individuals with higher levels of psychopathy tended to disobey newly introduced rules. On the other hand, a higher level of subclinical narcissism might have contributed to a better civil compliance. The results showed a significant positive correlation between the intensity of the Dark Triad and the occurrence of depressive symptoms. Furthermore, narcissism was linked to anxiety symptoms. These results can contribute to a better understanding of behavioural patterns during the COVID-19 pandemic within the group of individuals who exhibit the Dark Triad traits. Our conclusions might help to identify individuals who are particularly vulnerable to mental health problems.
‘All We Have to Decide Is What to Do with the Time That Is Given to Us’ a Photovoice Study on Physical Activity in Nursing Homes
Authors: Altmeier Dorothée , Thiel Ansgar , Frahsa Annika
Published: May 2021

(1) Background: Despite high prevalence of physical inactivity and sedentariness among nursing home residents, research on the influence of environments on this topic remains scarce. This Photovoice study explores how structural and social environments relate to residents’ everyday physical activity (PA). (2) Methods: 27 residents, staff, and significant others conducted Photovoice in eight nursing homes in Germany to document factors facilitating or hindering PA. Photographs were discussed with the participants in eight focus groups and analysed using thematic analysis. (3) Results: 169 photographs (between 8 and 42per home) were categorized into three thematic groups: (1) ‘architectural challenges for PA promotion in nursing homes’; (2) ‘opportunities and limitations of using daily work equipment for PA promotion’; (3) ‘social incentives for PA promotion’. Photographs’ foci in the homes differed considerably between participant groups. Staff primarily chose environmental constructions and aids that they perceived to enable residents’ PA. Residents were more likely to express affections and emotions that would encourage them to be active. (4) Conclusions: PA promotion research in this setting should be sensitive to diverse perceptions of different stakeholder groups and existing power imbalances. Interventions are needed that integrate residents’ needs and train staff on how to consider residents’ perspectives.
The Impact of COVID-19 on Canada’s Food Literacy: Results of a Cross-National Survey
Authors: Charlebois Sylvain , Music Janet , Faires Shannon
Published: May 2021

Several studies of food literacy emphasise the acquisition of critical knowledge over context. This evaluation looks at how COVID-19 impacted food literacy in a country affected by the global pandemic. To our knowledge, there has been no systematic research that would allow a better understanding of the impact of uncertainty or enhanced perceived risks generated by a global crisis on the prevalence of household food literacy. This study looks at food literacy from a perceptive of how an event that has domesticated many of them can alter knowledge and the relationship people have with food. A cross-national survey including 10,004 Canadians was conducted ten months after the start of the pandemic. Results show that Canadians have learned new recipes. Canadians have also taken up gardening and have relied on several sources to gather information. This study provides some evidence that Canadians have become more food literate because of the COVID-19 pandemic, but less significantly than anticipated. Practical and policy implications are presented as well as some future research directions.
The Relationship between Mindfulness and Emotional Intelligence as a Protective Factor for Healthcare Professionals: Systematic Review
Authors: Jiménez-Picón Nerea , Romero-Martín Macarena , Ponce-Blandón José Antonio , Ramirez-Baena Lucia , Palomo-Lara Juan Carlos , Gómez-Salgado Juan
Published: May 2021

Emotional intelligence is an essential trait and skill for healthcare professionals. Mindfulness meditation has proved to be effective in increasing the wellbeing of those who practice it, leading to better mental health, self-care and job satisfaction. This paper aims to identify the recent evidence on the relationship between mindfulness and emotional intelligence among healthcare professionals and students. A systematic review was conducted including the databases PubMed, Cinhal, PsycINFO and Web of Science. The main variables were emotional intelligence skills and mindfulness practice. Data were extracted according to the following outcomes: authors, year of publication, country, study design, participants, mindfulness training intervention, tools used in data collection and main results. The following inclusion criteria were applied: peer-reviewed articles; published in English or Spanish; published between 2010 and 2020; quantitative methodology; a study population of healthcare professionals or students; the relationship with the aim of the study. The Joanna Briggs Institute criteria were followed for assessing the methodological quality of the selected studies. Three researchers were involved in the review. After the selection process, 10 studies were selected out of the 197 references initially identified. These studies revealed a positive relationship between mindfulness and emotional intelligence, particularly the capacity to regulate emotions. Furthermore, mindfulness is negatively related to emotional exhaustion. Training interventions based on mindfulness have proved to be useful in promoting emotional balance, emotional awareness, emotional acceptance, emotion recognition, expressive suppression and a reduction in emotional exhaustion. This study could serve as a basis for further research on the benefits of emotional intelligence and practicing mindfulness for the bio-psycho-social welfare of healthcare professionals.
Validity and Reliability of a Novel Instrument for the Measurement of Subtalar Joint Axis of Rotation
Authors: Kim Byong Hun , Lee Sae Yong
Published: May 2021

Inclination of the subtalar joint (STJ) in the sagittal and transverse planes may be highly associated with ankle pathology. However, the validity and reliability of measuring the inclination of the STJ axis of rotation (AoR) is not well established. This study aimed to develop a custom-made STJ locator (STJL) and evaluate its reliability and validity. To establish the reliability and validity of the measurement device for STJ AoR, 38 healthy male participants were recruited. For the reliability analysis, test–retest was used, and for validity analysis, Pearson’s correlation and Bland–Altman plot analyses were performed. In the reliability analysis of the STJL, a higher correlation was observed with the sagittal plane (0.930) and transverse plane (0.748) (standard error of measurement: 0.56–0.78; minimal detectable difference: 1.57–2.16). In the validity analysis between radiography and STJL, a significantly higher value of 0.798 was obtained with radiography (42.5) and STJL (43.5) with the sagittal plane. The custom-made STJL may be used in the clinical setting as its validity and intraclass correlation coefficient were high, indicating consistent measurements. Further studies including motion analysis are necessary to provide more information regarding the relationship between STJ AoR inclinations and STJ movements.
Bone Mineral Density and Hemoglobin Levels: Opposite Associations in Younger and Older Women
Authors: Chuang Tzyy-Ling , Koo Malcolm , Chuang Mei-Hua , Wang Yuh-Feng
Published: May 2021

This cross-sectional, retrospective medical record review study aimed to investigate the association between hemoglobin levels and bone mineral density (BMD) in adult women. Medical records obtained from general health examinations conducted from June 2014 to July 2020 at a regional hospital in southern Taiwan were reviewed. Anthropometric and laboratory data were recorded. BMD of the lumbar spine and bilateral femoral neck regions was assessed by dual energy X-ray absorptiometry. Linear regression analysis was used to assess the association between BMD and hemoglobin level with and without adjusting for other anthropometric and laboratory data. The study included 9606 female patients with a mean age of 55.9 years. Of these, 2756 (28.7%) were aged ≤ 50 years and 6850 (71.3%) were aged > 50 years. Results from multiple linear regression analysis showed that hemoglobin and femoral and lumbar spine BMD were significantly correlated. A higher hemoglobin level was significantly associated with a lower BMD level in females aged ≤ 50 years, but with a higher BMD level in those aged > 50 years. Given the relationship between bone metabolism and hematopoiesis, additional research is needed to elucidate the association between hemoglobin and BMD levels in different age groups, particularly in premenopausal and perimenopausal women.
A Single Session of Whole-Body Electromyostimulation Increases Muscle Strength, Endurance and proNGF in Early Parkinson Patients
Authors: Fiorilli Giovanni , Quinzi Federico , Buonsenso Andrea , Casazza Giusy , Manni Luigi , Parisi Attilio , Di Costanzo Alfonso , Calcagno Giuseppe , Soligo Marzia , di Cagno Alessandra
Published: May 2021

Parkinson’s disease (PD) patients lead a sedentary lifestyle, being unable or unwilling to exercise conventionally, due to physical and mental limitations. The aim of this study was to assess the acute effects of a single session of whole-body electromyostimulation (WB-EMS) on the physical performances and serum levels of the neurotrophic factors in PD patients. Ten subjects (aged 72.60 ± 6.82) underwent 20 min of physical activity with superimposed WB-EMS and, after four weeks, the same protocol with no WB-EMS. WB-EMS was conducted with intermittent stimulation, with 4 s WB-EMS/4 s rest, at 85 Hz, 350 μs. A physical fitness assessment and blood samples collection, to evaluate neurotrophic factors’ levels (BDNF, FGF21, proNGF, mNGF), were collected before and after the intervention. The RM-ANOVA showed significant improvements in sit-to-stand (p < 0.01), arm curl (p < 0.01), handgrip (p < 0.01) and soda pop test (p < 0.01) after the WB-EMS intervention. Higher proNFG serum levels were observed in the WB-EMS condition compared to the no WB-EMS after 60 min post-intervention (p = 0.0163). The effect of WB-EMS confirmed the electrostimulation ability to modulate the proNGF quantity. The positive impact of the WB-EMS protocol on physical functioning, and eye–hand coordination, makes this intervention a promising strategy to improve motor and non-motor symptoms in PD patients.
Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2)
Authors: Pirro Martina , Mohammed Yassene , de Ru Arnoud H. , Janssen George M. C. , Tjokrodirijo Rayman T. N. , Madunić Katarina , Wuhrer Manfred , van Veelen Peter A. , Hensbergen Paul J.
Published: May 2021

Developments in mass spectrometry (MS)-based analyses of glycoproteins have been important to study changes in glycosylation related to disease. Recently, the characteristic pattern of oxonium ions in glycopeptide fragmentation spectra had been used to assign different sets of glycopeptides. In particular, this was helpful to discriminate between O-GalNAc and O-GlcNAc. Here, we thought to investigate how such information can be used to examine quantitative proteomics data. For this purpose, we used tandem mass tag (TMT)-labeled samples from total cell lysates and secreted proteins from three different colorectal cancer cell lines. Following automated glycopeptide assignment (Byonic) and evaluation of the presence and relative intensity of oxonium ions, we observed that, in particular, the ratio of the ions at m/z 144.066 and 138.055, respectively, could be used to discriminate between O-GlcNAcylated and O-GalNAcylated peptides, with concomitant relative quantification between the different cell lines. Among the O-GalNAcylated proteins, we also observed anterior gradient protein 2 (AGR2), a protein which glycosylation site and status was hitherto not well documented. Using a combination of multiple fragmentation methods, we then not only assigned the site of modification, but also showed different glycosylation between intracellular (ER-resident) and secreted AGR2. Overall, our study shows the potential of broad application of the use of the relative intensities of oxonium ions for the confident assignment of glycopeptides, even in complex proteomics datasets.
Identification and Toxicity Prediction of Biotransformation Molecules of Organophosphate Flame Retardants by Microbial Reactions in a Wastewater Treatment Plant
Authors: Choi Yeowool , Kim Sang Don
Published: May 2021

Organophosphate flame retardants (OPFRs) are substances added to plastics, textiles, and furniture, and are used as alternatives to brominated flame retardants. As the use of OPFRs increases in the manufacturing industry, the concentration in the aquatic environment is also increasing. In this study, OPFRs introduced into a wastewater treatment plant (WWTP) were identified, and the toxicity of biotransformation molecules generated by the biological reaction was predicted. Tris(2-butoxyethyl) phosphate, tris(2-butoxyethyl) phosphate, and triphenyl phosphate were selected as research analytes. Chemicals were analyzed using high-resolution mass spectrometry, and toxicity was predicted according to the structure. As a result, tris(1-chloro-2-propyl) phosphate showed the highest concentration, and the removal rate of OPFRs in the WWTP was 0–57%. A total of 15 biotransformation products were produced by microorganisms in the WWTP. Most of the biotransformation products were predicted to be less toxic than the parent compound, but some were highly toxic. These biotransformation products, as well as OPFRs, could flow into the water from the WWTP and affect the aquatic ecosystem.
Retinal Pigment Epithelium Remodeling in Mouse Models of Retinitis Pigmentosa
Authors: Napoli Debora , Biagioni Martina , Billeri Federico , Di Marco Beatrice , Orsini Noemi , Novelli Elena , Strettoi Enrica
Published: May 2021

In retinitis pigmentosa (RP), one of many possible genetic mutations causes rod degeneration, followed by cone secondary death leading to blindness. Accumulating evidence indicates that rod death triggers multiple, non-cell-autonomous processes, which include oxidative stress and inflammation/immune responses, all contributing to cone demise. Inflammation relies on local microglia and recruitment of immune cells, reaching the retina through breakdowns of the inner blood retinal barrier (iBRB). Leakage in the inner retina vasculature suggests similarly altered outer BRB, formed by junctions between retinal pigment epithelium (RPE) cells, which are crucial for retinal homeostasis, immune response, and privilege. We investigated the RPE structural integrity in three models of RP (rd9, rd10, and Tvrm4 mice) by immunostaining for zonula occludens-1 (ZO-1), an essential regulatory component of tight junctions. Quantitative image analysis demonstrated discontinuities in ZO-1 profiles in all mutants, despite different degrees of photoreceptor loss. ZO-1 interruption zones corresponded to leakage of in vivo administered, fluorescent dextran through the choroid-RPE interface, demonstrating barrier dysfunction. Dexamethasone, administered to rd10 mice for rescuing cones, also rescued RPE structure. Thus, previously undetected, stereotyped abnormalities occur in the RPE of RP mice; pharmacological targeting of inflammation supports a feedback loop leading to simultaneous protection of cones and the RPE.
Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats
Authors: Domínguez-Vías Germán , Segarra Ana Belén , Ramírez-Sánchez Manuel , Prieto Isabel
Published: May 2021

High saturated fat diets have been associated with the development of obesity and hypertension, along with other pathologies related to the metabolic syndrome. In contrast, the Mediterranean diet, characterized by its high content of monounsaturated fatty acids, has been proposed as a dietary factor capable of positively regulating cardiovascular function. These effects have been linked to changes in the local renal renin angiotensin system (RAS) and the activity of the sympathetic nervous system. The main goal of this study was to analyze the role of two dietary fat sources on aminopeptidases activities involved in local kidney RAS. Male Wistar rats (six months old) were fed during 24 weeks with three different diets: the standard diet (S), the standard diet supplemented with virgin olive oil (20%) (VOO), or the standard diet enriched with butter (20%) plus cholesterol (0.1%) (Bch). Kidney samples were separated in medulla and cortex for aminopeptidase activities (AP) assay. Urine samples were collected for routine analysis by chemical tests. Aminopeptidase activities were determined by fluorometric methods in soluble (sol) and membrane-bound (mb) fractions of renal tissue, using arylamide derivatives as substrates. After the experimental period, the systolic blood pressure (SBP) values were similar in standard and VOO animals, and significantly lower than in the Bch group. At the same time, a significant increase in GluAP and IRAP activities were found in renal medulla of Bch animals. However, in VOO group the increase of GluAP activity in renal medulla was lower, while AspAP activity decreased in the renal cortex. Furthermore, the VOO diet also affected other aminopeptidase activities, such as TyrAP and pGluAP, related to the regulation of the sympathetic nervous system and the metabolic rate. These results support the beneficial effect of VOO in the regulation of SBP through changes in local AP activities of the kidney.
Single-Photon Detection Module Based on Large-Area Silicon Photomultipliers for Time-Domain Diffuse Optics
Authors: Acerbi Fabio , Behera Anurag , Dalla Mora Alberto , Di Sieno Laura , Gola Alberto
Published: May 2021

Silicon photomultipliers (SiPM) are pixelated single-photon detectors combining high sensitivity, good time resolution and high dynamic range. They are emerging in many fields, such as time-domain diffuse optics (TD-DO). This is a promising technique in neurology, oncology, and quality assessment of food, wood, and pharmaceuticals. SiPMs can have very large areas and can significantly increase the sensitivity of TD-DO in tissue investigation. However, such improvement is currently limited by the high detector noise and the worsening of SiPM single-photon time resolution due to the large parasitic capacitances. To overcome such limitation, in this paper, we present two single-photon detection modules, based on 6 × 6 mm2 and 10 × 10 mm2 SiPMs, housed in vacuum-sealed TO packages, cooled to −15 °C and −36 °C, respectively. They integrate front-end amplifiers and temperature controllers, being very useful instruments for TD-DO and other biological and physical applications. The signal extraction from the SiPM was improved. The noise is reduced by more than two orders of magnitude compared to the room temperature level. The full suitability of the proposed detectors for TD-DO measurements is outside the scope of this work, but preliminary tests were performed analyzing the shape and the stability of the Instrument Response Function. The proposed modules are thus fundamental building blocks to push the TD-DO towards deeper investigations inside the body.
Influence of Psychological Biomarkers on Therapeutic Adherence by Patients with Non-Alcoholic Fatty Liver Disease: A Moderated Mediation Model
Authors: Funuyet-Salas Jesús , Martín-Rodríguez Agustín , Pérez-San-Gregorio María Ángeles , Romero-Gómez Manuel
Published: May 2021

Our aim was to analyze whether depressive symptoms mediated the association between physical quality of life (QoL) and adherence to physical activity in patients with non-alcoholic fatty liver disease (NAFLD), as well as the association between social support and adherence to diet. We also examined whether self-efficacy exerted a moderating role in these associations. QoL (SF-12), social support (MSPSS), depressive symptoms (HADS), self-efficacy (GSE), physical activity (IPAQ) and diet (MEDAS) were evaluated in 413 biopsy-proven NAFLD patients. Mediation and moderated mediation models were conducted using the SPSS PROCESS v3.5 macro. Results showed that depressive symptoms mediated the relationship between physical QoL and adherence to physical activity (indirect effect = 6.248, CI = 1.917–10.727), as well as the relationship between social support and adherence to diet (indirect effect = 0.148, CI = 0.035–0.275). Self-efficacy also moderated the indirect effects of QoL and social support on therapeutic adherence through depressive symptoms. Specifically, the higher self-efficacy was, the lower the negative impact on the NAFLD patient’s mental health. In conclusion, self-efficacy is defined as a protective factor for therapeutic adherence by NAFLD patients with a psychosocial risk profile. Self-efficacy should, therefore, be a main psychological target in future multidisciplinary NAFLD approaches.
Recent Advances in Multi-Scale Experimental Analysis to Assess the Role of Compatibilizers in Cellulosic Filler-Reinforced Plastic Composites
Authors: Teramoto Yoshikuni
Published: May 2021

Adding acid-modified resin compatibilizers is essential for plastic composites reinforced with carbon-neutral cellulosic filler. Researchers have measured the efficacy of adding a compatibilizer in the context of mechanics. However, it is necessary to microscopically clarify how the compatibilizer actually works for quality control and further expansion of applications. In this review, the author first describes the situation of cellulosic composites and presents issues regarding how one assesses the role of the compatibilizer. The author then reviews recent multi-scale experimental approaches to the detection of covalent bonds between the cellulosic filler and compatibilizer, estimation of nanoscale interphases, and the micron-scale dispersibility of the fillers. With accumulation of such experimental facts, appropriate parameter settings can be expected for the structural analysis such as the finite-element method, as well as the potential to provide appropriate explanatory variables for material/process informatics.
Demagnetization Effect on the Magnetoelectric Response of Composite Multiferroic Cylinders
Authors: Nacy Somer , Youssef George
Published: May 2021

Strain-mediated multiferroic composite structures are gaining scientific and technological attention because of the promise of low power consumption and greater flexibility in material and geometry choices. In this study, the direct magnetoelectric coupling coefficient (DME) of composite multiferroic cylinders, consisting of two mechanically bonded concentric cylinders, was analytically modeled under the influence of a radially emanating magnetic field. The analysis framework emphasized the effect of demagnetization on the overall performance. The demagnetization effect was thoroughly considered as a function of the imposed mechanical boundary conditions, the geometrical dimensions of the composite cylinder, and the introduction of a thin elastic layer at the interface between the inner piezomagnetic and outer piezoelectric cylinders. The results indicate that the demagnetization effect adversely impacted the DME coefficient. In a trial to compensate for the reduction in peak DME coefficient due to demagnetization, a non-dimensional geometrical analysis was carried out to identify the geometrical attributes corresponding to the maximum DME. It was observed that the peak DME coefficient was nearly unaffected by varying the inner radius of the composite cylinder, while it approached its maximum value when the thickness of the piezoelectric cylinder was almost 60% of the total thickness of the composite cylinder. The latter conclusion was true for all of the considered boundary conditions.
Lip Reading by Alternating between Spatiotemporal and Spatial Convolutions
Authors: Tsourounis Dimitrios , Kastaniotis Dimitris , Fotopoulos Spiros
Published: May 2021

Lip reading (LR) is the task of predicting the speech utilizing only the visual information of the speaker. In this work, for the first time, the benefits of alternating between spatiotemporal and spatial convolutions for learning effective features from the LR sequences are studied. In this context, a new learnable module named ALSOS (Alternating Spatiotemporal and Spatial Convolutions) is introduced in the proposed LR system. The ALSOS module consists of spatiotemporal (3D) and spatial (2D) convolutions along with two conversion components (3D-to-2D and 2D-to-3D) providing a sequence-to-sequence-mapping. The designed LR system utilizes the ALSOS module in-between ResNet blocks, as well as Temporal Convolutional Networks (TCNs) in the backend for classification. The whole framework is composed by feedforward convolutional along with residual layers and can be trained end-to-end directly from the image sequences in the word-level LR problem. The ALSOS module can capture spatiotemporal dynamics and can be advantageous in the task of LR when combined with the ResNet topology. Experiments with different combinations of ALSOS with ResNet are performed on a dataset in Greek language simulating a medical support application scenario and on the popular large-scale LRW-500 dataset of English words. Results indicate that the proposed ALSOS module can improve the performance of a LR system. Overall, the insertion of ALSOS module into the ResNet architecture obtained higher classification accuracy since it incorporates the contribution of the temporal information captured at different spatial scales of the framework.
1D–3D Coupling for Gas Flow Analysis of the Air-Intake System in a Compression Ignition Engine
Authors: Kim Kyong-Hyon , Kong Kyeong-Ju
Published: May 2021

Devices for reducing environmental pollutant emissions are being installed in ship compression ignition (CI) engines; alternatively, the designs of intake and exhaust pipes and ports are being modified to tune the performance according to the user’s needs. In both cases, substantial computation time and cost are required to simulate the gas flow of the CI engine with an air-intake system. In order to simulate the air-intake system of the CI engine, which changes according to the user’s needs, at a low cost and in a short time, we aimed to analyze the gas flow using a 1D–3D coupled method. The 1D zone was analyzed using the method of characteristics, and the 3D zone was analyzed using the commercial computational fluid dynamics (CFD) code Ansys Fluent R15.0, whereas their coupling was achieved by applying the developed 1D–3D coupling algorithm to Ansys Fluent R15.0 using user-defined functions (UDFs). In the comparison of the pressure of the intake pipe with the experimental result, the average error was 0.58%, thereby validating the approach. In addition, when analyzing the intake pipe and port in a 3D zone, the results of the velocity and pressure were expressed as contours, allowing them to be visualized. It is expected that the 1D–3D coupling algorithm of the air-intake system can be used to reflect the user’s needs and can be used as a method to quickly and accurately calculate the gas flow within tens of minutes.
Simultaneous Inhibition of Three Major Cytokines and Its Therapeutic Effects: A Peptide-Based Novel Therapy against Endotoxemia in Mice
Authors: Shih Hung-Jen , Chang Chao-Yuan , Chiang Milton , Le Van Long , Hsu Hao-Jen , Huang Chun-Jen
Published: May 2021

Three major cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, mediate endotoxemia-induced liver injury. With the similar structures to the binding domains of the three cytokines to their cognate receptors, the novel peptide KCF18 can simultaneously inhibit TNF-α, IL-1β, and IL-6. We elucidated whether KCF18 can alleviate injury of liver in endotoxemic mice. Adult male mice (BALB/cJ) were intraperitoneally (i.p.) administered lipopolysaccharide (LPS, 15 mg/kg; LPS group) or LPS with KCF18 (LKCF group). Mice in the LKCF group received KCF18 (i.p.) at 2 h (0.6 mg/kg), 4 h (0.3 mg/kg), 6 h (0.3 mg/kg), and 8 h (0.3mg/kg) after LPS administration. Mice were sacrificed after receiving LPS for 24 h. Our results indicated that the binding levels of the three cytokines to their cognate receptors in liver tissues in the LKCF group were significantly lower than those in the LPS group (all p < 0.05). The liver injury level, as measured by performing functional and histological analyses and by determining the tissue water content and vascular permeability (all p < 0.05), was significantly lower in the LKCF group than in the LPS group. Similarly, the levels of inflammation (macrophage activation, cytokine upregulation, and leukocyte infiltration), oxidation, necroptosis, pyroptosis, and apoptosis (all p < 0.05) in liver tissues in the LKCF group were significantly lower than those in the LPS group. In conclusion, the KCF18 peptide–based simultaneous inhibition of TNF-α, IL-1β, and IL-6 can alleviate liver injury in mice with endotoxemia.
Major United States Land Use as Influenced by an Altering Climate: A Spatial Econometric Approach
Authors: Cho Sung , McCarl Bruce
Published: May 2021

Climate and socioeconomic and policy factors are found to stimulate land use changes along with changes in greenhouse gas emissions and adaption behaviors. Most of the studies investigating land use changes in the U.S. have not considered potential spatial effects explicitly. We used a two-step linearized multinomial logit to examine the impacts of various factors on conterminous U.S. land use changes including spatial lag coefficients. The estimation results show that the spatial dependences have existed for cropland, pastureland, and grasslands with a negative dependence on forests but weakened in most of the land uses except for croplands. Temperature and precipitation were found to have nonlinear impacts on the land use shares in the succeeding years by exerting opposite effects on crop versus pasture/grass shares. We also predicted land use changes under different climate change scenarios. The simulation results imply that the southern regions of the U.S. would lose cropland shares with further severity under the business-as-usual climate scenarios, while the land use shares for pasture/grass and forest would increase in those regions. As land use plays an important role in the climate system and vice versa, the results from this study may help policymakers tackle climate-driven land use changes and farmers adapt to climate change.
Use of NanoSIMS to Identify the Lower Limits of Metabolic Activity and Growth by Serratia liquefaciens Exposed to Sub-Zero Temperatures
Authors: Schwendner Petra , Nguyen Ann N. , Schuerger Andrew C.
Published: May 2021

Serratia liquefaciens is a cold-adapted facultative anaerobic astrobiology model organism with the ability to grow at a Martian atmospheric pressure of 7 hPa. Currently there is a lack of data on its limits of growth and metabolic activity at sub-zero temperatures found in potential habitable regions on Mars. Growth curves and nano-scale secondary ion mass spectrometry (NanoSIMS) were used to characterize the growth and metabolic threshold for S. liquefaciens ATCC 27,592 grown at and below 0 °C. Cells were incubated in Spizizen medium containing three stable isotopes substituting their unlabeled counterparts; i.e., 13C-glucose, (15NH4)2SO4, and H218O; at 0, −1.5, −3, −5, −10, or −15 °C. The isotopic ratios of 13C/12C, 15N/14N, and 18O/16O and their corresponding fractions were determined for 240 cells. NanoSIMS results revealed that with decreasing temperature the cellular amounts of labeled ions decreased indicating slower metabolic rates for isotope uptake and incorporation. Metabolism was significantly reduced at −1.5 and −3 °C, almost halted at −5 °C, and shut-down completely at or below −10 °C. While growth was observed at 0 °C after 5 days, samples incubated at −1.5 and −3 °C exhibited significantly slower growth rates until growth was detected at 70 days. In contrast, cell densities decreased by at least half an order of magnitude over 70 days in cultures incubated at ≤ −5 °C. Results suggest that S. liquefaciens, if transported to Mars, might be able to metabolize and grow in shallow sub-surface niches at temperatures above −5 °C and might survive—but not grow—at temperatures below −5 °C.
Influence of Laser Energy Input and Shielding Gas Flow on Evaporation Fume during Laser Powder Bed Fusion of Zn Metal
Authors: Qin Yu , Liu Jinge , Chen Yanzhe , Wen Peng , Zheng Yufeng , Tian Yun , Voshage Maximilian , Schleifenbaum Johannes Henrich
Published: May 2021

Laser powder bed fusion (LPBF) of Zn-based metals exhibits prominent advantages to produce customized biodegradable implants. However, massive evaporation occurs during laser melting of Zn so that it becomes a critical issue to modulate laser energy input and gas shielding conditions to eliminate the negative effect of evaporation fume during the LPBF process. In this research, two numerical models were established to simulate the interaction between the scanning laser and Zn metal as well as the interaction between the shielding gas flow and the evaporation fume, respectively. The first model predicted the evaporation rate under different laser energy input by taking the effect of evaporation on the conservation of energy, momentum, and mass into consideration. With the evaporation rate as the input, the second model predicted the elimination effect of evaporation fume under different conditions of shielding gas flow by taking the effect of the gas circulation system including geometrical design and flow rate. In the case involving an adequate laser energy input and an optimized shielding gas flow, the evaporation fume was efficiently removed from the processing chamber during the LPBF process. Furthermore, the influence of evaporation on surface quality densification was discussed by comparing LPBF of pure Zn and a Titanium alloy. The established numerical analysis not only helps to find the adequate laser energy input and the optimized shielding gas flow for the LPBF of Zn based metal, but is also beneficial to understand the influence of evaporation on the LPBF process.
Selective Laser Melted M300 Maraging Steel—Material Behaviour during Ballistic Testing
Authors: Szachogłuchowicz Ireneusz , Fikus Bartosz , Grzelak Krzysztof , Kluczyński Janusz , Torzewski Janusz , Łuszczek Jakub
Published: May 2021

Significant growth in knowledge about metal additive manufacturing (AM) affects the increase of interest in military solutions, where there is always a need for unique technologies and materials. An important section of materials in the military are those dedicated to armour production. An AM material is characterised by different behaviour than those conventionally made, especially during more dynamic loading such as ballistics testing. In this paper, M300 maraging steel behavior was analysed under the condition of ballistic testing. The material was tested before and after solution annealing and ageing. This manuscript also contains some data based on structural analysis and tensile testing with digital image correlation. Based on the conducted research, M300 maraging steel was found to be a helpful material for some armour solutions after pre- or post-processing activities. Conducted solution annealing and ageing increased the ballistic properties by 87% in comparison to build samples. At the same time, the material’s brittleness increased, which affected a significant growth in fragmentation of the perforated plate. According to such phenomena, a detailed fracture analysis was made.