bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Patch Test Results with the T.R.U.E. Test and Demographic Findings in Periorbital Dermatitis: A 10‐Year Retrospective Analysis
Authors: Unal Alkım
Published: September 2024

The most common cause of periorbital dermatitis is allergic contact dermatitis. This study aimed to determine the patch test results and demographic characteristics in patients diagnosed with periorbital dermatitis by evaluating their patch test results between 2012 and 2022. The thin‐layer rapid‐use epicutaneous test (T.R.U.E. test) results of patients diagnosed with periorbital dermatitis over the specified period were retrospectively evaluated. Of the 102 patients included in the study, 58 (56.9%) had a positive reaction to at least one allergen. The most common allergens to which the patients had positive reactions were nickel sulfate (31.0%), gold sodium thiosulfate (19.0%), fragrance mix (13.8%), balsam of Peru (10.3%), colophony (10.3%), cobalt dichloride (8.6%), formaldehyde resin (6.9%), thimerosal (5.2%), quaternium‐15 (5.2%), carba mix (5.2%), and potassium dichromate (5.2%). This study provides comprehensive data on the demographic characteristics and patch test results of patients with periorbital dermatitis.
Triple‐Composed Metric Spaces and Related Fixed Point Results With Application
Authors: Kil Chol Jin , Ho Kwang , Yang Won-Chol , Kim Un Ok
Published: September 2024

This paper introduces the concept of triple‐composed metric space as a new generalization of double‐composed metric space and rectangular b‐metric space. We also prove fixed point results of nonlinear FT‐contractions in such spaces, which is an improvement and extension of previous results concerning F‐contraction. Furthermore, we discuss the application to nonlinear integral equations.
Excess Mortality in Persons with Concurrent HIV and Cancer Diagnoses: A Retrospective Cohort Study
Authors: Lee Kamaria L. , Sarovar Varada , Lam Jennifer O. , Leyden Wendy A. , Alexeeff Stacey E. , Lea Alexandra N. , Hechter Rulin C. , Hu Haihong , Marcus Julia L. , Yuan Qing , Kramer Jennifer R. , Lin Lilie L. , Chiao Elizabeth Y. , Towner William J. , Horberg Michael A. , Silverberg Michael J.
Published: September 2024

Background:

With extended lifespans for people with human immunodeficiency virus (PWH), there is a corresponding increased burden of chronic illnesses, including cancer. Our objective was to estimate the excess mortality among PWH with cancer compared with people without HIV (PWoH), accounting for the higher background mortality in the general PWH population.

Methods:

We identified 39,000 PWH and 387,767 demographically matched PWoH in three integrated healthcare systems from 2000 to 2016. We estimated excess mortality among PWH with cancer, computed as the cancer mortality rate difference-in-difference comparing PWH and PWoH. We evaluated five cancer groups: any cancer; virus-, human papillomavirus–, and Epstein–Barr virus –related cancers; virus-unrelated cancers, and common individual cancers. We fitted a multivariable additive Poisson model to estimate excess mortality among PWH with cancer.

Results:

PWH with any cancer had excess mortality compared with PWoH [41.3/1,000 person-years (py), 95% confidence interval (CI), 34.0–48.7]. The highest excess mortality was observed for Epstein–Barr virus–related cancers (63.2/1,000 py, 95% CI, 47.8–78.7), lung cancer (147.7/1,000 py, 95% CI, 41.1–254.3), and non–Hodgkin lymphoma (70.5/1,000 py, 95% CI, 51.4–89.6). Excess mortality among PWH was attenuated from 2009 to 2016, and PWH with cancer had no excess mortality 5 years after diagnosis.

Conclusion:

PWH in care may have excess mortality from certain cancer types, although disparities may have attenuated over time and do not persist beyond 5 years after diagnosis.

Impact:

Findings may guide improved clinical practice and suggest further research is needed to investigate whether cancer treatment or other factors contribute to mortality disparities for PWH with cancer.
Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Authors: Teijeira Alvaro , Garasa Saray , Ochoa Maria C. , Sanchez-Gregorio Sandra , Gomis Gabriel , Luri-Rey Carlos , Martinez-Monge Rafael , Pinci Beatrice , Valencia Karmele , Palencia Belen , Barbés Benigno , Bolaños Elixabet , Azpilikueta Arantza , García-Cardosa Marina , Burguete Javier , Eguren-Santamaría Iñaki , Garate-Soraluze Eneko , Berraondo Pedro , Perez-Gracia Jose L. , de Andrea Carlos E. , Rodriguez-Ruiz Maria E. , Melero Ignacio
Published: September 2024

Supplementary Figure S1. Autocrine IL-8 is secreted upon low-dose g-irradiation.
Supplemental Data S1 from Tumor-Localized Interleukin-2 and Interleukin-12 Combine with Radiation Therapy to Safely Potentiate Regression of Advanced Malignant Melanoma in Pet Dogs
Authors: Stinson Jordan A. , Barbosa Matheus Moreno P. , Sheen Allison , Momin Noor , Fink Elizabeth , Hampel Jordan , Selting Kim A. , Kamerer Rebecca L. , Bailey Keith L. , Wittrup Karl D. , Fan Timothy M.
Published: September 2024

Supplemental Data S1. Supplemental Data File containing raw data generated in this study.
Supplementary Figure S5 from Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy
Authors: Yang Yazi , Qin Sen , Yang Mengyu , Wang Ting , Feng Ru , Zhang Chunli , Zheng Enrun , Li Qinghua , Xiang Pengyu , Ning Shangyong , Xu Xiaodong , Zuo Xin , Zhang Shuai , Yun Xiaoya , Zhou Xuehong , Wang Yue , He Lin , Shang Yongfeng , Sun Luyang , Liu Hui
Published: September 2024

Supplementary Figure S5. BCMA CAR-T Therapy Enhances the Proportion and Cytotoxic Activity of CD8+ Effector T Cells, Positively Correlating with Therapeutic Responsivity.
Supplementary Figure S4 from Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy
Authors: Yang Yazi , Qin Sen , Yang Mengyu , Wang Ting , Feng Ru , Zhang Chunli , Zheng Enrun , Li Qinghua , Xiang Pengyu , Ning Shangyong , Xu Xiaodong , Zuo Xin , Zhang Shuai , Yun Xiaoya , Zhou Xuehong , Wang Yue , He Lin , Shang Yongfeng , Sun Luyang , Liu Hui
Published: September 2024

Supplementary Figure S4. Quality Control of the Public scRNA-seq Dataset and Clustering of the Cells within the MM Microenvironment.
Figure S2 from Oral and Gut Microbiome Alterations in Oral Chronic GVHD Disease: Results from Close Assessment and Testing for Chronic GVHD (CATCH Study)
Authors: Rashidi Armin , Pidala Joseph , Hamilton Betty K. , Pavletic Steven Z. , Kim Katie , Zevin Alex , Mays Jacqueline W. , Lee Stephanie J.
Published: September 2024

Comparison of microbiome composition between specific subgroups
Figure S1 from Oral and Gut Microbiome Alterations in Oral Chronic GVHD Disease: Results from Close Assessment and Testing for Chronic GVHD (CATCH Study)
Authors: Rashidi Armin , Pidala Joseph , Hamilton Betty K. , Pavletic Steven Z. , Kim Katie , Zevin Alex , Mays Jacqueline W. , Lee Stephanie J.
Published: September 2024

Taxonomic composition of positive controls
Supplementary Figure S4 from Phase II Trial of HER-Vaxx, a B-cell Peptide-Based Vaccine, in HER2-Overexpressing Advanced Gastric Cancer Patients Under Platinum-Based Chemotherapy (HERIZON)
Authors: Tobias Joshua , Maglakelidze Marina , Andrić Zoran , Ryspayeva Dinara , Bulat Iurie , Nikolić Ivan , Petrović Zoran , Chawla Tanuj , Nagarkar Rajnish , Garner-Spitzer Erika , Zielinski Christoph C. , Chong Leslie Mi Ok , Nixon Bonnie , Ede Nicholas J. , Yavrom Sharon , Kundi Michael , Wiedermann Ursula
Published: September 2024

Supplementary Figure S4. The Kaplan-Meier estimate of PFS.
Supplementary Figure 3 from Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei
Authors: Martínez-Quintanilla Jordi , Cabot Débora , Sabia Doménico , Arqués Oriol , Vergés Jordi , Chicote Irene , Bijelic Lana , Cabellos Laia , Alcántara Anna M. , Ramos Isabel , Barrios Pedro , Crusellas Oriol , Palacio Lina M. , Cámara Juan A. , Barriuso Jorge , Jiménez Juan J. , Muñoz-Torres Pau , Nonell Lara , Flores Raquel , Médico Enzo , Guaglio Marcello , Ros Javier , Élez Elena , Tabernero Josep , Aziz Omer , Deraco Marcello , Palmer Héctor G. , Giovanna Chiorino , Francesco Mazzarotto , Manuela Gariboldi , Luca Varinelli , Tommaso Cavalleri , Bipasha Chakrabarty , Raghavendar Nagaraju , Patrick Caswell , Milly McAllister
Published: September 2024

Supplementary Figure 3. PMP5.1-PDX model preserves oncogenic mutations from the original patient sample.
Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer
Authors: Lee Hey Min , Saw Ajay Kumar , Morris Van K. , Napolitano Stefania , Bristow Christopher , Srinivasan Sanjana , Peoples Micheal , Sorokin Alexey , Kanikarla Marie Preeti , Schulz Jonathan , Singh Anand K. , Terranova Christopher , Coker Oluwadara , Jain Abhinav , Kopetz Scott , Rai Kunal
Published: September 2024

Purpose:

BRAFV600E-mutated colorectal cancer exhibits a strong correlation with DNA hypermethylation, suggesting that this subgroup of tumors presents unique epigenomic phenotypes. Nonetheless, 5-azacitidine, which inhibits DNA methyltransferase activity, is not efficacious in BRAFV600E colorectal cancer in vivo.

Experimental Design:

We randomized and treated mice implanted with patient-derived tumor xenografts harboring BRAFV600E mutation with control, 5-azacitidine, vemurafenib (BRAF inhibitor), or the combination. Comprehensive epigenomic profiling was conducted on control and 5-azacitidine–treated tumor samples, including DNA methylation, histone modifications, chromatin accessibility, and gene expression. Combinations of epigenetic agents were explored in preclinical BRAFV600E colorectal cancer models.

Results:

A profound reduction of DNA methylation levels upon 5-azacitidine treatment was confirmed, however, transcriptional repression was not relieved. This study unbiasedly explored the adaptive engagement of other epigenomic modifications upon 5-azacitidine treatment. A loss of histone acetylation and a gain of histone methylations, including H3K27 and H3K4 trimethylation, were observed around these hypomethylated regions, suggesting the involvement of polycomb repressive complex (PRC) activity around the genome with loss of DNA methylation, therefore maintaining the repression of key tumor-suppressor genes. Combined inhibition of PRC activity through EZH2 inhibition with 5-azacitidine treatment additively improved efficacies in BRAFV600E colorectal cancer cells.

Conclusions:

In conclusion, DNA hypomethylation by 5-azacitidine exhibits a close association with H3K27me3 and PRC activity in BRAFV600E colorectal cancer, and simultaneous blockade of DNA methyltransferase and EZH2 holds promise as a potential therapeutic strategy for patients with BRAFV600E-mutated colorectal cancer.
PTPRZ1-Targeting RNA CAR T Cells Exert Antigen-Specific and Bystander Antitumor Activity in Glioblastoma
Authors: Martinez Bedoya Darel , Marinari Eliana , Davanture Suzel , Castillo Cantero Luis , Erraiss Sarah , Dockerill Millicent , Barluenga Sofia , Winssinger Nicolas , Schaller Karl , Bijlenga Philippe , Momjian Shahan , Voize Christel , Tissot Stéphanie R. , Kandalaft Lana E. , Hammel Philippe , Cosson Pierre , Walker Paul R. , Dutoit Valérie , Migliorini Denis
Published: September 2024

The great success of chimeric antigen receptor (CAR) T-cell therapy in the treatment of patients with B-cell malignancies has prompted its translation to solid tumors. In the case of glioblastoma (GBM), clinical trials have shown modest efficacy, but efforts to develop more effective anti-GBM CAR T cells are ongoing. In this study, we selected protein tyrosine phosphatase receptor type Z (PTPRZ1) as a target for GBM treatment. We isolated six anti-human PTPRZ1 single-chain variable fragments from a human phage display library and produced second-generation CAR T cells in an RNA format. Patient-derived GBM PTPRZ1–knockin cell lines were used to select the CAR construct that showed high cytotoxicity while consistently displaying high CAR expression (471_28z). CAR T cells incorporating 471_28z were able to release IFNγ, IL2, TNFα, granzyme B, IL17A, IL6, and soluble FasL and displayed low tonic signaling. Additionally, they maintained an effector memory phenotype after in vitro killing. In addition, 471_28z CAR T cells displayed strong bystander killing against PTPRZ1-negative cell lines after preactivation by PTPRZ1-positive tumor cells but did not kill antigen-negative nontumor cells. In an orthotopic xenograft tumor model using NOD/SCIDγ mice, a single dose of anti-PTPRZ1 CAR T cells significantly delayed tumor growth. Taken together, these results validate PTPRZ1 as a GBM target and prompt the clinical translation of anti-PTPRZ1 CAR T cells.
Figure S1 from Putrescine Supplementation Limits the Expansion of pks+ Escherichia coli and Tumor Development in the Colon
Authors: Oliero Manon , Cuisiniere Thibault , Ajayi Ayodeji S. , Gerkins Claire , Hajjar Roy , Fragoso Gabriela , Calvé Annie , Vennin Rendos Hervé , Mathieu-Denoncourt Annabelle , Dagbert François , De Broux Éric , Loungnarath Rasmy , Schwenter Frank , Sebajang Herawaty , Ratelle Richard , Wassef Ramses , Richard Carole , Duperthuy Marylise , Gravel Andrée E. , Vincent Antony T. , Santos Manuela M.
Published: September 2024

Figure S1 shows E. coli metabolome and ornithine decarboxylase activity
Supplementary Data 1 Legend from Exploration of Immune-Modulatory Effects of Amivantamab in Combination with Pembrolizumab in Lung and Head and Neck Squamous Cell Carcinoma
Authors: Lim Sun M. , Kang Seong-san , Kim Dong K. , Lee Soo-Hwan , Synn Chun-Bong , Baek Sujeong , Yang Seung M. , Han Yu J. , Kim Mi H. , Han Heekyung , Na Kwangmin , Kim Young T. , Yun Mi R. , Kim Jae H. , Byeon Youngseon , Kim Young S. , Lee Jii B. , Hong Min H. , Curtin Joshua C. , Patel Bharvin , Bergiers Isabelle , Pyo Kyoung-Ho , Cho Byoung C.
Published: September 2024

Data legend for supplementary data 1, showing the process chart and raw whole slide images of multiplex IHC.
C-Kit Immunohistochemical Expression as a Complementary Method to Assess Mast Cell Density in Helicobacter pylori-Mediated Gastritis
Authors: Ismael Ava T. , Abdulhameed Rafal A. , Hamdi Bushra A. , Tawfeeq Rawaz D. , Ommar Aram
Published: September 2024

Introduction: Chronic gastritis is a group of conditions commonly characterized by stomach lining inflammation. The study aimed to investigate the clinical and pathological aspects that play a role in its development. Additionally, the study examines the use of CD117 as an immunohistochemistry marker in evaluating mast cell density (MCD). Methods: This retrospective, cross-sectional study was conducted in Iraqi Kurdistan with a sample size of 380 patients. Patient data included gastritis type, neutrophil infiltration severity, mononuclear cell infiltration within the lamina propria, intestinal metaplasia, and glandular atrophy, which were categorized and given a score. The CD117 level was identified using an anti-human rabbit polyclonal antibody. Results: A statistically significant association was revealed between Helicobacter pylori-mediated gastritis and non-specific gastritis with age, activity, H. pylori and MCD, dysplasia, and malignancy. Meanwhile, no association was found with gender, inflammatory infiltrate, intestinal metaplasia, and glandular atrophy. C-Kit exhibited a marked increase in MCD in patients with H. pylori-mediated gastritis, intestinal metaplasia, atrophy, and gastric carcinoma. However, a significant decrease in MCD was observed on repeating endoscopy evaluations for patients after treatment. Conclusion: Regions that exhibit severe inflammation, metaplasia, atrophy, and carcinoma demonstrated an increase in MCD with H. pylori-mediated gastritis. A detailed investigation in clinical practice to screen early diagnosis and treatment needs to be performed in high H. pylori prevalence.
Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review
Authors: Ding Yunbu , Wang Chaofan , Bi Lingbo , Du Yimei , Lu Changpei , Zhao Min , Fan Weixin
Published: September 2024

Background: Androgenetic alopecia (AGA) is a common skin disease characterized by gradually miniaturized hair follicles, which manifests as progressive hair thinning and produces a bald appearance. Currently, finasteride is approved by the Food and Drug Administration (FDA) for the treatment of AGA, but its efficacy remains poor in some patients. Summary: Compared to finasteride, oral dutasteride has better efficacy and similar tolerability, and most adverse events are mild and reversible, making it an effective option for AGA, but its sexual adverse events and potential psychiatric risks still need to be concerned. Mesotherapy with dutasteride and microneedling combined with dutasteride solution can reduce adverse events caused by oral medication and exhibit certain efficacy, but standardized treatment protocols and large-scale clinical trials are still needed in the future. Liposomes or nanoparticles of dutasteride are under development and may become an efficient topical formulation. Key Messages: We have summarized the efficacy and AEs of dutasteride in treating AGA under different administration methods and the promise of novel topical drug carriers.
Prognostic Factors for Treatment Failure of Photodynamic Therapy and 5-Fluorouracil in Bowen’s Disease
Authors: Ahmady Shima , Nelemans Patty J. , Abdul Hamid Myrurgia , Demeyere Thomas B.J. , van Marion Arienne M.W. , Kelleners-Smeets Nicole W.J. , Mosterd Klara
Published: September 2024

Introduction: Little is known about prognostic factors that may influence the response to non-invasive treatments of patients with Bowen’s disease. The aim of this study was to identify patient and lesion characteristics that are associated with a higher risk of treatment failure after 5-fluorouracil and photodynamic therapy in Bowen’s disease. The hypothesis that the thickness of the Bowen’s lesion and extension along the hair follicle is associated with the risk of treatment failure after noninvasive treatment was also explored. Methods: Data were derived from a non-inferiority randomized trial in which 169 patients were treated with 5% 5-fluorouracil cream twice daily for 4 weeks or 2 sessions of methylaminolevulinate photodynamic therapy with 1-week interval. All patients had histologically confirmed Bowen’s disease of 4–40 mm. The initial 3 mm biopsy specimens were re-examined to measure the maximum histological lesion thickness and extension along the hair follicle. To evaluate the association between potential risk factors for treatment failure at 1-year follow-up, univariate and multivariate logistic regression analyses were used to calculate odds ratios (ORs) with 95% confidence intervals and p values. Results: Histological lesion thickness was not significantly associated with treatment failure (OR: 0.84, p = 0.806), nor was involvement of the hair follicle (OR: 1.12, p = 0.813). Lesion diameter was the only risk factor that was significantly associated with 1-year risk of treatment failure (OR = 1.08 per mm increase, p = 0.021). When using the median value of 10 mm as cut-off point, the risk of treatment failure was 23.4% for lesions >10 mm compared to 10.3% for lesions ≤10 mm (OR: 2.66, p = 0.028). Conclusions: Only clinical lesion diameter was identified as a prognostic factor for response to non-invasive therapy in Bowen’s disease.
Short Version of the Quality of Life Relevance-Acne Questionnaire
Authors: Chernyshov Pavel V. , Zouboulis Christos C. , Marron Servando E. , Boffa Michael J. , Manolache Liana , Pustišek Nives , Bettoli Vincenzo , Koumaki Dimitra , Tomas-Aragones Lucia
Published: September 2024

Introduction: The goal of the present study was to develop a short version (SV) of the Quality of Life Relevance-Acne (QOLRELEVANCE-ACNE) based on the identified most relevant items for acne patients. Methods: Members of the international internet group for acne patients were asked to fill in the short prototype version of the QOLRELEVANCE-ACNE. Internal consistency was measured using Cronbach’s alpha. Results: The answers of 684 acne patients were collected. The analysis revealed that the internal consistency of the instrument could be improved by removing a single item. That item was removed and the final four-item short version of the QOLRELEVANCE-ACNE-SV was formed. There is minimal or no overlapping of the QOLRELEVANCE-ACNE-SV with other brief forms of acne-specific HRQoL instruments. Conclusion: The four-item QOLRELEVANCE-ACNE-SV questionnaire was developed and showed good internal consistency. An international validation study of the QOLRELEVANCE-ACNE-SV will be performed.
Two decades of HIV/AIDS mortality trend analysis in the Philippines
Authors: Balt Arafat M. , Mangotara Rosnia D. , Sambawa Nihaya G. , Alamada Princess Altheya Mae P. , Demayo Chin-chin J. , Demayo Cesar G.
Published: September 2024

Public health surveillance indicates that the country's HIV infection rate is rising, with the Western Pacific region experiencing the highest growth. Due to the scarcity of studies on HIV in the nation, the present state of the HIV epidemic must be ascertained by gathering data from public health surveillance and HIV mortality time trend analysis. The Department of Health's Philippine Health Statistics (PHS) provided the information. The PHS-recommended algorithms for vital health indicators were used to calculate mortality rates. According to the study's findings, the death rate in the nation is rising, necessitating tight efforts to stop the virus's transmission and provide access to anti-retroviral therapy. Although there is a considerable difference between the two sexes, men had a greater mortality rate than women, suggesting that men were more vulnerable to HIV/AIDS mortality. The study also revealed that HIV testing hurdles were to blame for making young to middle-aged individuals the population most susceptible to mortality from this illness. Additionally, the National Capital Region has the most significant mortality rate, so the government should focus on promoting health in this area as it has the highest mortality rate.
General mental health and new media literacy among Malaysian adult urbanites
Authors: Emeralda Dee , Che Hasan Abdul Hadi , Ho Yi Ming , Prihadi Kususanto Ditto
Published: September 2024

This study investigates the multifaceted interplay of risk and protective factors influencing general mental health (GMH), focusing on the impact of external validation seeking through online interactions and the protective role of perceived social support (PSS) against GMH problems, mediated by unconditional self-acceptance (USA) and PSS with new media literacy (NML) is introduced as a moderator variable, affecting the interplay between PSS, USA, and interpersonal mattering (IPM) in predicting GMH. A moderated serial mediation model was proposed and tested with 380 purposively recruited adult urbanites from Malaysia. The results reveal that individuals with high NML perceive greater social support, leading to higher self-acceptance and mattering, enhanced GMH protection. This study highlights the critical role of NML in the digital age’s impact on GMH.
Determinants of caregiver burden in community-dwelling caregivers of patients with severe and persistent mental illness
Authors: Mulud Zamzaliza Abdul , Goodwin John , Mohamad Norfidah , Wahab Patimah Abdul
Published: September 2024

Loss of independence due to cognitive and functional ability is the main challenge experienced by individuals with severe mental illness. This study aimed to investigate the associated factors of caregiver burden among caregivers of individuals with severe and persistent mental illness living in the community. We used a cross-sectional design with open-ended questions to determine the contributing factors to caregiver burden. A self-administered questionnaire was used to measure caregiver burden and resilience (n=201). Caregiver burden and resilience were operationalised using the caregiver burden inventory scale (CBI) and connor-davidson resilience scale (CD-RS), respectively. The findings showed that the caregivers were experiencing a moderate level of caregiver burden (M=30.7, SD=20.3). Caregiving-related stressors are the most important predictor of caregiver burden, explaining 28.3% of the variance in caregiver burden. Finally, the hierarchical analysis found that resilience, caregiver-related stressors and socio-demographic factors contributed to 52.4% of the variance in caregiver burden. New factors that contributed to the burden, such as lack of support and knowledge deficit, emerged from the qualitative findings. The results highlighted the growing evidence of the role of caregivers' socio-demographic variables, caregiving-related stressors and resilience to caregiver burden.
Evaluating factors in urban dengue prevention and control during Indonesia's COVID-19
Authors: Boerman Baequni , Nasir Narila Mutia , Karyadi Karyadi
Published: September 2024

Amidst the COVID-19 pandemic, dengue hemorrhagic fever (DHF) persisted as a critical public health challenge in South Tangerang. This study employed a cross-sectional design and snowball sampling technique to evaluate the engagement of urban communities in dengue prevention, involving 234 participants. Findings indicate that while practices such as container emptying (76.5%) and water storage sealing (57.7%) were prevalent, activities like mosquito larvae inspection (36.3%) and breeding item disposal (34.6%) were less common. Alarmingly, personal protective measures, including mosquito net usage (11.1%) and repellent application (16.7%), were significantly lacking. Statistical analyses revealed notable correlations (p-value<0.05) between dengue prevention behaviours and factors, including beliefs, attitudes towards prevention, support from family and healthcare professionals, and knowledge about dengue prevention. The study highlights a critical disparity in dengue prevention efforts, showing a community bias towards environmental management over personal protection strategies. It calls for increased participation from families and healthcare professionals in dengue prevention initiatives and stresses the need for governmental interventions to improve training for healthcare workers. Ultimately, the study advocates for a comprehensive approach that merges environmental management with personal protective measures, urging governments to adopt integrated strategies for more effective dengue prevention.
 
The role of midwives in preventing malaria in pregnant women: qualitative study from South-West Sumba Regency, Indonesia
Authors: Kencanawati Dewa Ayu Putu Mariana , Ndapa Conchita Emiliana , Martha Evi
Published: September 2024

Pregnant women in Indonesia, particularly in the Southwest Sumba Regency are faced with high malaria incidence. To overcome the challenge, midwives play a crucial role in integrating malaria services into maternal and child health (MCH) program. Therefore, this study aimed to examine the role of midwives in the implementation of integrated MCH services in the Southwest Sumba district. The location and participants were carefully selected and data collection was performed using the semi-structured interview method, which was divided into three sections. These included i) understanding of midwives regarding malaria and dangers to pregnant women, ii) the implementation of integrated malaria services for the MCH program, and iii) the role of midwives. The collected data were thematically analyzed and narratively presented based on the themes. The results showed that midwives in North Kodi District had a limited understanding of malaria. Consequently, the implementation of integrated MCH services, including specialized preventive education for pregnant women, was not at the optimal level. This phenomenon showed the need for malaria education, preparation of service standards, facilitative supervision, and cross-sectoral collaboration.
Examining stigma dynamics: a scoping review of social network analysis in communicable disease contexts
Authors: Baharuddin Izyan Hazwani , Ismail Nurhuda , Patterson Megan S. , Yasin Siti Munira , Naing Nyi Nyi , Ibrahim Khalid
Published: September 2024

The global COVID-19 pandemic has brought attention to the profound impact of stigma on individuals, communities, and societies. Social network analysis (SNA), based on network theory, offers a transformative approach to investigate the complex interplay of social structures, relationships, and information dissemination in communicable disease contexts. This scoping review aims to examine the utilization of SNA in studying stigma dynamics related to communicable diseases, assess the current research landscape, identify gaps, and highlight key findings. Three databases (Scopus, Web of Science, and PubMed) were searched for studies on SNA and stigma in communicable diseases. From the identified studies, three eligible articles were selected for review, providing insights into the role of stigma as a barrier to social integration, thereby impacting network centrality. The review also explores patterns of stigma communication on social media and examines the impact of interventions on individuals’ social networks. Overall, this review emphasizes the value of SNA in comprehending the intricate relationships between social networks and stigma in communicable disease contexts.
Nursing outcomes guideline in major post-floods communities in Indonesia
Authors: Agianto Agianto , Setiawan Herry , Nasri Novi Mustahdiati , Yunara Yulia , Karunia Muhammad , Aminullah Muhammad Fasya , Noo Rezka Aulyan , Yulianti Dwi Wanda
Published: September 2024

Health problems resulting from flooding have a very significant role in the sustainability of people's lives. Major floods hit South Kalimantan, Indonesia in 2021. The impact of the flooding will cause nursing problems in the community. There has been no research on nursing outcomes for communities affected by floods, although research has been conducted on identifying nursing diagnoses for post-flood communities. The aim of the research is to develop nursing outcomes for nursing diagnosis in post-flood communities in Indonesia. Descriptive analytics with a cross-sectional approach. The research sample was 140 people with a consecutive sampling technique using a questionnaire with 207 assessment items on nursing outcomes for nursing diagnoses that emerged in post-flood communities. Univariate analysis was used. The 14 nursing diagnoses that emerged in flood-affected communities, there are 33 nursing outcomes labels with 91 outcome indicators. Nursing diagnoses and nursing outcomes that have been obtained can be made into a guidebook for nursing care in post-flood communities. The quality of nursing services can be improved when a disaster occurs to reduce disability, complications and even death during and after a flood disaster.
Social support as a key factor in the health promotion model: influencing diabetic wound prevention behavior
Authors: Suyanto Suyanto , Sukartini Tintin , Noor Mohammad Arifin
Published: September 2024

Diabetic foot wounds are a serious problem that threatens the quality of life of diabetes patients. Individual factors, family, and social support have an important role in preventing diabetic foot wounds. This research aims to determine the aspects of social support in preventing diabetic foot wounds. The research employed a cross-sectional design, involving 120 respondents. The Modified Diabetic Foot Care Behavior (MD FCB) instrument was used to assess behavior related to diabetic foot care. Data analysis was conducted using logistic regression. The results indicated a positive correlation between high levels of social support and the prevention of diabetic foot wounds. In assessing patient knowledge about foot care, it was found that 20 people (16.7%) had poor knowledge. Additionally, low family support was seen in 23 people (19.2%), low peer support in 17 people (14.2%), and low support from health workers in 15 people (12.5%). Furthermore, 42 people (35%) exhibited poor behavior in preventing foot wounds. The Chi-square test revealed a significant influence of knowledge on behavior for preventing diabetic foot wounds (p-value 0.001). Meanwhile, the correlation between family support, peer support, and support from health workers in relation to diabetic foot wound prevention behavior was significant, with each showing a p-value of 0.01. Enhancing social support is identified as an effective strategy for reducing the risk of diabetic foot wounds and their associated complications. Therefore, efforts to increase social support levels for diabetes patients should be considered an integral part of their care regimen.
Nurses’ attitude towards communication with intubated conscious patients: an online survey
Authors: Karmakar Mahuya , Said Faridah Mohd , Panduragan Santhna Letchmi
Published: September 2024

The lack of communication causes dissatisfaction and distress among conscious intubated patients, which may result in treatment refusal. This preliminary study sought to identify attitudes of nurses towards communication with conscious intubated patients. Thus, possible solutions to improve the communication challenges if exist by finding the attitude of nurses on communication with conscious intubated patients may be explored. Preliminary survey was conducted among selected nurses through convenient sampling method. Questionnaire self-developed, validated were distributed and analyzed descriptively. Almost all respondents believed that conscious patients do want to communicate during intubated period and eighty two percent of the respondents agreed that communication with conscious intubated patients is possible. Seventy five percent respondents have tried to communicate using both verbal and non-verbal methods but 70% have faced challenges. Though only thirty seven percent of the respondents have been taught how to communicate with the intubated conscious patients, sixty four percent of respondents have never asked for any tools for communication. To overcome the communication challenges majority 103 (82.4%) of the respondents stated the requirement of standardized communication tool. The result indicates a need to develop standardized communication tool to ease communication with conscious intubated patients.
Noise exposure and hearing threshold levels of rice mill workers
Authors: Rachmawati Siti , Suryadi Iwan , Fitriani Nurlaila , Firmansyah Fathoni , Nisya Khoirun
Published: September 2024

Industrial noise is generally one of the risk factors for occupational and environmental safety and health. Noise is a risk factor for decreased hearing threshold value in addition to other factors such as age, working period. This study used a cross-sectional design that aimed to identify the hearing threshold level (HTL) of rice mill workers exposed to hazardous noise in Karanganyar Regency, and investigate the relationship with other factors such as age, tenure. Audiometric data from 92 participants were collected through audiometric examination by qualified personnel using an audiometer in a quiet environment. The test was conducted after the participants had rested completely for >14 hours after their last exposure to workplace noise. The results showed that all participants had worked in a noise-hazard work zone for >1 year. The participants' ages ranged from 28 to 57 years. The average hearing threshold in the right ear was 36.71 dB and the average hearing threshold in the left ear was 39.55 dB. The hearing loss associated with work experience was greater than that caused by noise intensity age. Noise intensity, age and working experience were significant to the workers' ear hearing threshold values. Multivariate test results show that noise intensity is the most influential factor (>60%) on HTL. HTL among industrial workers should be assessed regularly. At the health policy level, these workers need to start being protected when they start working.
Validating psychometric properties of dual-continua models for university student mental health assessment
Authors: Aziz Rahmat , Mangestuti Retno
Published: September 2024

This study rigorously evaluates a mental health assessment tool for college students, grounded in the dual-continua model, which uniquely captures both positive (psychological well-being) and negative (psychological distress) mental health dimensions. Employing a sample of 312 students evenly split by gender, the research meticulously tested the tool's reliability and construct validity. Reliability was confirmed through a robust Cronbach's Alpha of .807, indicating consistency in responses. Construct validity was assessed via confirmatory factor analysis, affirming the tool's capacity to accurately measure the intended constructs with well-being and distress components scoring .828 and .875, respectively. This validation process underscores the instrument's precision and significant contribution to mental health research by providing a nuanced understanding of student mental health through dual-continua models. The findings offer a refined resource for mental health professionals and universities, facilitating the development of targeted interventions. However, the study acknowledges limitations, including its cross-sectional design and the need for further validation across diverse student populations, to ensure the tool's broad applicability and effectiveness in varied contexts.
Development of disaster nursing competency assessment instruments
Authors: Pandawa Rugaya Munawar , Saleh Fatmah M , Muhammad Ramli
Published: September 2024

It is important to ensure that nurses have sufficient skills and knowledge to handle emergency situations. This competency assessment can help improve nurses' readiness to face disasters and emergency situations that may occur. To develop an unobtrusive (observation) instrument for assessing disaster nursing competency which refers to the International Council of Nurses (ICN) disaster nursing competency framework, especially earthquake and volcano disasters. The starting date for the design of the disaster nursing competency assessment instrument was 2023. Then, the implementation of the research to test the instrument, which had been validated by experts using disaster nursing practice simulations, was conducted for a month from February to March 2023. The research design uses Design-Based, the sample criteria were active student status, emergency nursing, and disaster management courses. The total number of respondents was 80 students, and in the initial stage of testing the instrument during disaster simulation observations, a limited sample of 20 respondents was taken at random and assessed by five lecturers as raters. The instrument development stage started with the specification of the ICN disaster nursing competency assessment instrument. The Aiken index for the unobtrusive observation technique instrument with competency assessment rubric is high, valid, and met reliability requirements. Multifaceted analysis compared students, items, and lecturers from small and large samples. The analysis reveals that students' difficulty levels vary according to the assessing lecturer, with some mastering all items and others only mastering specific ones.
Paternal breastfeeding self-efficacy in South Tangerang, Indonesia: a qualitative study
Authors: Sabilla Mizna , Sartika Ratu Ayu Dewi
Published: September 2024

Studies focusing on paternal confidence in supporting breastfeeding remain relatively scarce, especially in Indonesia. The purpose of this study was to explore paternal breastfeeding self-efficacy among fathers in Indonesia. This study used a qualitative approach with ten participants, including fathers and mothers with children aged 6-24 months who had experience in exclusive breastfeeding. It took place in South Tangerang City between May and July 2023. Fathers participated in focus group discussions, while mothers underwent in-depth interviews. The data analysis utilized content analysis, referring to the theme of the Self-efficacy framework. This study revealed that fathers felt less confident when dealing with issues such as the baby's low weight, breastfeeding refusal, and the mother returning to work. However, seeing the consequences of not exclusively breastfeeding and the support from health workers and the community helped them stay confident. These factors, along with a sense of pride and satisfaction, strengthened their ability to support exclusive breastfeeding. Paternal breastfeeding self-efficacy is dynamic. However, previous experience, observation of others, verbal persuasion, and positive emotions strengthen fathers' beliefs. Parents need to consult a lactation counselor when facing problems while breastfeeding. Counselors can provide assistance and motivation to remain confident and continue to exclusively breastfeed.
Transcranial Doppler With Microbubbles: Screening Test to Detect and Grade Right-to-Left Shunt After an Ischemic Stroke: A Literature Review
Authors: Palazzo Paola , Heldner Mirjam R. , Nasr Nathalie , Alexandrov Andrei V.
Published: September 2024

Right-to-left shunt, mainly due to patent foramen ovale (PFO), is likely responsible for ≈5% of all ischemic strokes and 10% of those occurring in young and middle-aged adults. Randomized clinical trials demonstrated that, in selected young and middle-aged patients with otherwise cryptogenic acute ischemic stroke and high-risk PFO, percutaneous PFO closure is more effective than antiplatelet therapy alone in preventing recurrence. However, PFO is generally a benign finding and is present in about one-quarter of the population. Therefore, in clinical practice, identifying PFOs that are likely to be pathogenetic is crucial for selecting suitable patients for PFO closure to prevent recurrent stroke and to avoid potentially harmful and costly overtreatment. Contrast transthoracic echocardiography has a relatively low sensitivity in detecting PFO, whereas transesophageal echocardiography is currently considered the gold standard for PFO detection. However, it is a relatively invasive procedure and may not always be easily feasible in the subacute setting. Contrast transcranial Doppler is a noninvasive, inexpensive, accurate tool for the detection of right-to-left shunt. We conducted a literature review on the use of contrast transcranial Doppler to detect and grade right-to-left shunt after an acute ischemic stroke and present a clinical workflow proposal for young and middle-aged patients.
Prerequisites for the Positioning of Scientific Disciplines: An Analysis Including Values, Norms, and Science-Related Issues
Authors: Haase Michaela
Published: September 2024

Scientific disciplines are faced with the need to position themselves as part of both science and society. This article explores the foundations of such positioning on the basis of a sociological model of the division of disciplinary labor, interpreted as a general model of the social organization of disciplinary labor, as well as on the basis of models of science and of the science–society relationship. As models of the relationship between science and society, the republican American model and the model of the scientific public sphere embody the normative ideals of autonomous and embedded science that are essential for the positioning of a scientific discipline. With cognition as the main goal of science, the (post-)positivist roots of the close connection between basic research and instrumental knowledge are explored. The transformation discourse testifies to the interest in solving complex problems in democratic science; and the concept of scientific knowledge as a common good links science and society by pointing to the possibility of a public interest in scientific knowledge. The article concludes that a scientific community needs axiological skills in addition to theoretical, methodological, and communicative skills.
Artistic Resistance and Resilience in Sank, or the Patience of the Dead, by Aristide Tarnagda
Authors: Tiendrebeogo Pingdewindé Issiaka
Published: September 2024

Burkina Faso has faced a security crisis unlike any other in its history for the past eight years. The government has lost control of up to 35 % of the national territory, and there are as many as two million internally displaced persons living in the big cities. The emblematic figure of Thomas Sankara, Burkina Faso’s president from 1984 to 1987, has soared beyond the local image of the “upright man” (the ideal to which the very name “Burkina Faso” refers) to that of a globally recognised icon of resistance against imperialism. Theatre artists are inspired to create theatrical performances that “represent” (or “face up”) this great figure, as the recent edition of the Ouagadougou-based biannual theatre festival called Les Récréâtrales invited them to do. This paper emphasises theatre’s contribution to efforts of artistic resilience and resistance in Burkina Faso. It addresses the question: How do Burkinabè artists produce acts of artistic resilience through performance? In other words, does the staging proposed by the Burkinabè playwright Aristide Tarnagda carry the seeds of hope for a Burkina Faso entirely liberated from terrorism? The theory of communication developed by J.L. Austin in How to Do Things With Words (1962) and Anne Ubersfeld’s (1982) semiotic analysis theory provide the key critical concepts of this study.
The Ethiopia-Egypt Controversy on the Renaissance Dam and the Role of a Benefit-Sharing Approach in the Nile Basin
Authors: Alamineh Asabu Sewenet
Published: September 2024

The Nile River has been both an engine of development and a cause of controversy among its riparian states for millennia. This paradox took on an international dimension with the inception of the Grand Ethiopian Renaissance Dam (GERD). Using a qualitative research method, this paper investigates the GERD controversy and the role of a benefit-sharing approach in the Nile Basin. The dam negotiations have been hampered by unjust colonial treaties, the hardline interests of Egypt and Ethiopia, politicisation, uncertainty about the consequences of the dam’s use and lopsided third-party intervention. The paper argues that the adoption of a benefit-sharing approach in the basin can sustain the Nile ecosystem, promote regional peace, increase water flow and decrease unnecessary expenses through modest intraregional cooperation. The resolution of the Nile Basin conflict thus relies on identifying the potential of the basin and on integrated cooperative frameworks adopted by the technocrats of its riparian states and international experts.
Hydro Political Relation in the Eastern Nile Basin
Authors: Mulugeta Getaye , Asress Degu
Published: September 2024

Hydropolitical relations have long attracted the world of academia, and hydrohegemony and counter-hydrohegemony frameworks have recently become important in analysing power relations between riparian states. However, little attention has been given to the hydrohegemonic situation of the Nile River. This study tries to analyse this status, specifically in the Eastern Nile Basin. The data, elicited through unstructured interviews from purposively selected informants, has been analysed thematically. The findings reveal that Egypt aspires to be a hegemon in the basin but is not. Despite its use of different coercive and subtle mechanisms to induce ideational or hegemonic compliance, these have not been successful: Ethiopia has not consented to or accepted Egypt’s claim over the Nile. Concomitantly, since the 1990s, Ethiopia’s position has transcended from veiled to overt contest, which anticipates a new order, challenging the monopolistic position of Egypt.