bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlations between Immunoinflammatory Factor Levels and Cognitive Functions and Brain Structural Magnetic Resonance Imaging Features among Patients with Primary Schizophrenia
Authors: Pan Xin , Su Wei , Wang Zhenhua , Jin Xilong , Chen Zinan , Jin Haiying , Chen Haizhi
Published: August 2024

Background: Schizophrenia is associated with significant cognitive impairment. However, the pathophysiological mechanisms underlying cognitive dysfunction in schizophrenia remain unclear. Based on the latest concept of cognition, immunoinflammatory factors and structural magnetic resonance imaging (sMRI) features of the brain are considered markers of schizophrenia. This study explored the correlations between cognitive function and immunoinflammatory factors and sMRI in primary schizophrenia patients. 
Methods: Non-interventional cross-sectional study was conducted, including 21 patients with primary schizophrenia, who were identified based on the Diagnostic and Statistical Manual, Fifth Edition (DSM-V) and grouped under the observation group. Thirty healthy volunteers with age, gender, hand dominance, and education duration matched with those of the primary schizophrenia patients were recruited to the control group. All subjects underwent sMRI examination. MATRICS consensus cognitive battery (MCCB) was employed to assess the cognitive functions among patients with primary schizophrenia. The levels of serum amyloid A (SAA), monocyte chemoattractant protein 1 (MCP-1), and chitinase-3-like protein 1 (YKL-40) were measured by means of enzyme-linked immunosorbent assay (ELISA). Pearson's correlation analysis was carried out to analyze the correlation between immunoinflammatory factor levels and cognitive functions as well as brain sMRI features. 
Results: The scores for all MCCB items and the total score for the observation group were apparently lower than those for the control group (p < 0.001), while the YKL-40 and SAA levels were notably higher in the observation group (t = 3.406, p < 0.05; t = 5.656, p < 0.001). Compared to the control group, the observation group exhibited reduced volumes of left and right insular lobes, left and right anterior cingulate cortexes, left and right hippocampi, right parahippocampal gyrus, right amygdala, left inferior occipital lobe, left superior temporal lobe, left temporal pole, and left middle and inferior temporal lobes (p < 0.001). The levels of YKL-40 and SAA were both negatively correlated with MCCB score (r = –0.3668, p = 0.004; r = –0.8495, p < 0.001). The volumes of right insular lobe, left and right anterior cingulate cortexes, right parahippocampal gyrus, right amygdala, and gray matter in left middle temporal lobe were all negatively correlated with the levels of YKL-40 and SAA (p < 0.05). 
Conclusion: Cognitive impairment in patients with primary schizophrenia is associated with increased serum SAA and YKL-40 levels and decreased gray matter volume.
The Role of Professionalism, Auditor’s Experience, and Independence in Improving the Quality of Audit Results: Empirical Study on The Government Internal Monitoring Apparatus ITJEN Kemendikbudristek
Authors: Prasetya Budi Agung , Purwana Dedi , Muhtar Saparuddin
Published: August 2024

The Government Internal Monitoring Apparatus  is an important part of government management to realize good governance. This research aims to carry out analysis through the stages of identifying, reviewing, and proving hypotheses, as well as finding variables that influence the quality of audit results. The research method used is a mixed parallel convergent method. This research analyzes data through two analyses: quantitative and qualitative analysis, quantitative data was collected through questionnaires from 201 ITJEN Kemendikbudristek auditors. while qualitative data was obtained through interviews and observation. The analysis technique uses SPSS 26.0, Amos 5, and QSR NVivo 20.2 software. Research results from the quantitative analysis show that the level of professionalism, experience, independence, and quality of audit results at ITJEN Kemendikbudristek is in the sufficient category. The causal relationship between professionalism, experience, independence, and the quality of audit results is not significantly strengthened by the existence of the working time moderating variable. The model with the moderating variable  produces a fit model. Likewise, the proposed model without the moderating variable produces a fit model. A model that can not only interpret samples but also interpret the population as a whole. The model without the moderating variable has a much more effective model, namely 15.2%, compared to the model with working time with a model effectiveness level of 15.1%. The research results from the qualitative analysis show that the level of professionalism, experience, independence, and quality of audit results at ITJEN Kemendikbudristek is in the sufficient category. These results are in line with the results of quantitative analysis using arithmetic average calculations. For this reason, increasing the professionalism, experience, and independence of auditors, which is currently considered sufficient, will further improve the quality of audit results when the level of professionalism, experience, and independence increases.
Political Parties Reform In Developing The Competence And Professionalism Of The Legislative Members Of The House Of Representatives Of The Republic Of Indonesia (DPR RI)
Authors: Antonio Renville , Wijoyo Suparto , Abrianto Bagus Oktafian , . Achintya , Negara Dharma Setiawan , . Lufsiana
Published: August 2024

PT Pembangkitan Jawa-Bali (PJB), in developing its company, does many things, such as innovating which incidentally is believed to be able to encourage a company to improve its economic performance. One form of innovation carried out by PT PJB is partnering with several universities in Indonesia. The collaboration is expected to be able to build synergies between agencies through the empowerment of facilities and human resources. This research aims to determine the relationship between inter-organizational partnerships on corporate innovation (incremental innovation type) and determine the relationship between inter-organizational partnerships on corporate innovation (radical innovation type). This research is a research with a quantitative approach using statistical analysis tools in testing hypotheses. To measure the relationship between organizational partnership and innovation, this research uses an ordered probit model approach. The research uses the inter-organizational partnership variable as the independent variable along with several other control variables. The research uses data obtained from the results of questionnaires have been distributed to several employees from various levels randomly from PT PJB. Furthermore, the research also uses data obtained from the results of researchers' observations of key informants have been selected. Partnerships between organizations (with educational institutions) can contribute to company performance. Company performance is described through the birth of innovation (both incremental and radical types). The research indirectly implies the statement that partnerships between organizations can affect the company's performance through the innovations developed within the company. Furthermore, the research also seeks to create an effective partnership design in generating company innovation. The limitation of this research is data source of this research is only based on PT PJB, in order to the future an analysis of partnerships with educational institutions can be carried out on the performance of other companies. The novelty of this research is focus to analyze the relationship of partnerships with educational institutions on the performance of companies, especially in PT PJB which has not been carried out by other studies.
Youth Character Building Through Quality Education in Realizing Golden Indonesia 2045
Authors: Pasaribu Munawir , Khairifa Feni , Ali Rahmadi , Muis Andi Abd , Ritonga Maisaroh
Published: August 2024

This article aims to explore adolescent character building through quality education in realizing a Golden Indonesia 2045. These two goals are part of Indonesia's SDGs. Adolescent character development in Indonesia is on an upward trend, so a character education strategy is needed to achieve the golden goal. The urgency of this article is to formulate character development that is qualified in terms of a series of opportunities and challenges faced by the Indonesian nation. This article uses a qualitative method with a literature study approach. The primary sources of this article are education policy documents and relevant recent literature. Meanwhile, the secondary data used in this study are reportage documents and supporting research. The results show that there are three domains that must be suppressed in achieving a Golden Indonesia 2045, namely: 1) Ongoing Conflict, 2) Safety and Security and 3) Militarization. In addition to peace, there are eight factors of justice and educational efforts that can be implemented in achieving SDG's point number 16. On the other hand, the realization of this Gold must be accompanied by multiracial, gender and multireligious knowledge. Building the ideal adolescent character in realizing a Golden Indonesia 2045 involves quality education that emphasizes moral integrity, social skills, a sense of responsibility, and awareness of justice values. Quality education that can realize a Golden Indonesia 2045 requires a holistic approach that integrates character building, multicultural inclusiveness, social skills development, and the participation of all relevant parties. Critical Pedagogy and Social Development theories have an important role in reviewing and creating novelty in this research. The focus of development rests on aspects of criticality, social skills and understanding by encouraging collaboration. Then local values, history and religion become one of the reinforcing factors in achieving a Just and Peaceful Indonesia.
Humanizing Pedagogy: The Human-Centric Approach to Technology Integration for Teacher Training
Authors: Dhliwayo Alice , Jita Thuthukile
Published: August 2024

The rapid expansion of Information and Communication Technologies (ICTs) in education has the potential to revolutionise higher educational opportunities and promote social development for students through techno-equipped teacher educators. However, despite this intensive growth, for Sub-Saharan Africa, a substantial gap still exists between the widespread use of ICTs and their effective implementation in education. In this theoretical paper, we examine the challenges and consequences embedded in this gap in higher education, through the lens of humanising pedagogy, with a focus on the potential harm to the students’ social development. The study however makes some crucial recommendations on policy and practice through an exploration of strategies and propositions for bridging this divide to utilise the full educational potential of ICTs in the African higher education context. We argue for the adoption of humanising pedagogy in higher education for better contribution towards economic and social development through education. We conclude by presenting a suggested model, which we termed ‘Human-centric ICT integration Model’ for effective integration of the said ICTs in a humanistic approach for preservice teacher training.
Problems Of Many-Valued Logic from The Point of View of The Theory of Socio-Cultural Code
Authors: Ibragim Suleimenov , Oleg Gabrielyan , Yelizaveta Vitulyova,
Published: August 2024

It is shown that there are prerequisites for returning to the original interpretation of logic as the science of the laws of thought. Using the methods of the neural network theory of the noosphere, it is proved that the nature of thinking is significantly influenced by the socio-cultural code of the ethnic/social system. A connection is revealed between philosophical categories as basic undefined concepts and archetypes, understood according to Jung. It is proved that the formalization of the laws of thinking, built on multi-valued logic, should operate not only and not so much with the concepts of natural language, but with “reflection quanta” lying on the archetypal level of consciousness. It is shown that the category of truth underlying classical logic can also be interpreted as a “reflection quantum”, but which has undergone a formalization procedure. It is demonstrated how exactly the apparatus of multi-valued logic can be applied to identifying links between the "quanta of reflection", which can be considered as a generalization of the rules of reasoning established in classical logic, dating back to Aristotle. The category “Qi”, which underlies ancient Chinese philosophy and is inseparable from the Chinese sociocultural code, was used as an example. Meaning of this category in the version that is assimilated by European and Eurasian sociocultural codes is revealed.
Applying Technology Acceptance Model Theory on Distributing Electronic Money the Role of Intention Power
Authors: Latief Fitriani , Mus Abdul Rahman , Amang Baso , Hasan Sabri , Mahmud Amir
Published: August 2024

The use of electronic money is currently very massive, but in some areas the use of money This electronic also still encounters many obstacles, this is because there is still a need for education and socialization in the distribution of electronic money. Objective: This study aims to analyze the use of TAM theory in distributing electronic money and its influence on usage decisions through the power of interest as an intervening variable. Research Design, Data, and Methodology: This research is a quantitative research that uses primary data from questionnaires distributed to respondents. Research data is processed through path analysis. Data processing and analysis is carried out using Smart-PLS 04 software. Results:  this study proves directly the perception of usability of use and perception of ease of use affects the decision of use, ease of use affects the strength of interest, the perception of the benefits of use does not affect the strength of interest, the strength of interest is proven to affect the decision of use, while indirectly the perception of usefulness of use does not affect the decision of use through strength interest and perception of ease of use influence the decision to use through the power of interest Conclusion: The use of electronic money still requires better socialization and education and in educational efforts to distribute electronic money using TAM theory, it is also necessary to emphasize the level of security and risk so that the usefulness of electronic money can be better understood by the public
The Influence of Corruption on Management in Modern Russia
Authors: Moiseev Vladimir  V. , Kolesnikova Julia S. , Yagudina Elena V. , Kuznetsova Alsu M. , Molchanova Marina A.
Published: August 2024

It has been established that the Russian Federation is one of the countries with a high level of corruption. Corruption has affected almost all levels of government. In 2023, its global anti-corruption ranking was very low, ranking 137th between Paraguay and Kyrgyzstan. This fact negatively affected the socio-economic development of modern Russia. The authors sought not only to reveal the reasons for its unprecedented growth over the past two decades, but also to show how corruption slows down the country's economic development, and why Russian anti-corruption policies do not produce real results. Based on factual material, the authors not only show the increase in the scale of corruption, point out significant shortcomings of anti-corruption policies and Russian legislation, but also identify the main ways to improve them for the purpose of further socio-economic development and improvement of public administration. There is a certain connection between the effectiveness of public management and corruption. This study can provide government authorities and management bodies of both Russia and other post-Soviet states, where the level of corruption is also high, with real assistance in improving the forms and methods of anti-corruption policy.
5. PENGARUH JUMLAH JAM KERJA TERHADAP KELELAHAN PERSONIL ATC (AIR TRAFFIC CONTROLER ) STUDI KASUS BANDARA TJILIK RIWUT
Authors: Ivan Yusri  , Muchammad Furqon Muchaddats  , Kurniawan P.Y.  , Dikatama T
Published: August 2024

Penelitian ini dilaksanakan bertujuan untuk menyelidiki dan mendatapengaruh jam kerja yang diberlakukan terhadap kelelahan pada personel Air TrafficControl (ATC) di Perum LPPNPI Cabang Palangka Raya. Metode penelitian yangdigunakan adalah penelitian kuantitatif dengan pendekatan survei. Pengumpulan datadilakukan dengan menggunakan kuesioner yang disebarkan kepada 12 personel ATC diPerum LPPNPI Cabang Palangka Raya. Data dianalisis menggunakan statistik deskriptifdan statistik inferensial dengan uji t.Hasil penelitian menunjukkan bahwa penerapan jamkerja personel ATC di Perum LPPNPI Cabang Palangka Raya belum memenuhiketentuan yang ditetapkan dalam KP 218. Rata-rata jam kerja personel ATC per mingguadalah 48 jam, melebihi batas maksimal 32 jam per minggu. Hasil penelitian jugamenunjukkan bahwa terdapat pengaruh yang signifikan antara jam kerja terhadapkelelahan pada personel ATC di Perum LPPNPI Cabang Palangka Raya. Semakin lamajam kerja personel ATC maka semakin tinggi pula tingkat kelelahan yang dialaminya.Berdasarkan hasil penelitian, disarankan kepada manajemen Perum LPPNPI CabangPalangka Raya untuk meninjau kembali jam kerja personel ATC untuk memastikan telahmematuhi peraturan yang ditetapkan dalam KP 218. Selain itu, pihak manajemen jugahendaknya menerapkan program manajemen kelelahan untuk mengurangi risikokelelahan di kalangan personel ATC.
6. RANCANGAN RUTE PENERBANGAN APPROACH CONTROL AREA DI WILAYAH UDARA ELTARI
Authors: Ivan Yusri  , Muchammad Furqon Muchaddats  , Kurniawan P.Y.  , Dikatama T
Published: August 2024

Penelitian ini bertujuan untuk merencanakan desain konsep rutepenerbangan/ rute ATS dan titik-titik penting di wilayah udara APP/TMA Kupang yangakan digunakan sebagai sarana rute lalu lintas udara disalah satu kepulauan Indonesiatimur yang terus meningkat pada setiap tahunnya dalam hal ini untuk meningkatkankeselamatan dan efisiensi lalu lintas udara khususnya di APP/TMA Kupang. Terdapatbeberapa tantangan dalam penyelenggaraan pelayanan lalu lintas udara di wilayah udaraAPP/TMA Kupang. Pertama, terdapat 13 bandara perintis di wilayah udara yang tidakmemiliki rute ATS. Hal ini dapat menimbulkan konflik antar pesawat dan juga menyulitkanATC untuk menyediakan layanan pemisahan. Kedua, SOP saat ini tidak menyebutkanketentuan mengenai penerbangan yang tidak memiliki rute ATS serta dapat menimbulkankebingungan dan risiko keselamatan. Ketiga, jangkauan radio komunikasi di wilayahudara tidak selalu memadai sehingga menyulitkan ATC untuk berkomunikasi denganpesawat. Menurut surve pada tahun 2016, Indonesia menduduki peringkat keempatdalam 10 besar pasar penumpang domestik di dunia, oleh karena itu perlu adanyapenambahan rute penerbangan sebagai sarana lalu lintas udara yang akan segeradilaksanakan pada kesempatan pertama oleh Perum LPPNPI Kantor Cabang Kupang.Untuk menjamin keselamatan penerbangan, penting untuk memiliki layanan navigasiudara yang memadai Perum LPPNPI Kantor Cabang Kupang bertanggung jawabterhadap pelayanan lalu lintas udara di wilayah udara APP/TMA Kupang.
Current Perspectives in the Forensic Analysis of Timbers using Vibrational Spectroscopy: A Review
Authors: Yadav Arti , Sharma Sweety , Gupta Lovlish , Singh Vaibhav , Singh Rajinder
Published: August 2024

Wildlife crime has increased significantly with respect to timbers such as illegal timber trading, logging, harvesting, and counterfeiting. It has tremendously drained the economy of different countries since timber trafficking at the global level has an average annual net worth of US$ 50-150 billion. Moreover, timbers can act as important forensic evidence as they can be found at the crime scenes revealing the relationships between the crime scene and corpus delicti. Since ancient times, various traditional techniques have been used for timber identification such as anatomical investigation by visual method at the macroscopic and microscopic levels. However, morphological and anatomical techniques have some advantages, such as cost effectiveness, and limitations as they require experienced personnel. Vibrational spectroscopic tools such as infrared and Raman spectroscopy help in discriminating various species of timber as different timber species have unique phytochemicals. By examining the concentrations of cellulose, lignin, and hemicelluloses, the chemical composition can also be estimated. Herein, this review is carried out using vibrational spectroscopic methods for timber identification to combat criminal activities related to timbers for the dissemination of justice. Recent advancements and prospects are also emphasized in this review paper.
2024年开来科技（深圳）有限公司教育部产学合作协同育人项目申报指南
Authors: 开来科技（深圳）有限公司
Published: August 2024

2024年，开来科技（深圳）有限公司拟在“四新”领域建设、教学内容和课程体系改革、师资培训、实践条件和实践基地建设、创新创业教育改革等方面开展产学合作协同育人项目，计划立项30项，支持高校的人才培养和专业综合改革。
A systematic review on the early detection of oral cancer using artificial intelligence and electronic tongue technology
Authors: Abid Dr. Maryam , Khero Dr. Rabail , Ali Dr. Iqra , Zareef Prof. Dr. Uzma , Haque Dr. Arifa , Faizan Dr. Afshan
Published: August 2024

This systematic review examines the role of artificial intelligence (AI) and electronic tongue (e-tongue) technology in the early detection of oral cancer. A comprehensive search of PubMed, Scopus, and Web of Science databases identified 500 articles, of which 20 met the inclusion criteria and were included in the review. The included studies encompassed diverse methodologies, AI models, and e-tongue technologies, with a total of 5,000 participants across various populations. AI-driven models, particularly those utilizing deep learning algorithms, demonstrated high sensitivity (>85%) and specificity (>80%) in detecting oral cancer biomarkers. E-tongue technologies, such as mass spectrometry and optical sensors, contributed to enhanced diagnostic accuracy, with area under the curve (AUC) values exceeding 0.85 in several studies. While promising, challenges such as study heterogeneity, validation in large-scale trials, and implementation barriers require further attention. The findings highlight the transformative potential of AI and e-tongue technology in revolutionizing oral cancer screening and management, with implications for improving patient outcomes and reducing healthcare costs. Future research should focus on standardization, validation, and real-world implementation to harness the full benefits of these innovative approaches in clinical practice.
Breaking the Silence: The Role of Health Professionals in the Gaza Crisis
Authors: Siddiqui Dr Faiza
Published: August 2024

Having the opportunity to write something in this moment, I would use it to raise my voice on behalf of the health professional community for the people of Gaza. As mentioned by Sualeha Shekhani and Dr. Aamir Jafarey, doctors represent the moral voice of their era. However, in light of the events of October 7, 2023, and the subsequent armed assault by Israeli forces on Gaza, which has led to a significant humanitarian crisis, the response from the global bioethics community seems muted (Shekhani & Jafarey, 2024). This silence can be partly explained by editorial restraints that may prevent a more robust response from the health community towards the Gaza crisis. Health professionals are uniquely positioned to influence policy decisions and advocate for equitable healthcare. They possess specialized knowledge of medical ethics and healthcare structures, enabling them to champion the causes of the vulnerable and reduce disparities across society. Physicians, trained in evidence-based medicine, can ensure that policy decisions are grounded in scientific research rather than political expediency (Fernandes, 2024). The medical community's silence regarding the Gaza crisis is troubling. Healthcare workers in Gaza are targeted, and doctors work without essential medicines and resources, risking their lives for the population they serve. The current health sector in Gaza is at a breaking point, exacerbating the public health crisis and psychological trauma experienced by the residents (Fernandes, 2024).
Reviving Ancient Wisdom: Evidence-Based Study of Unani Medicines on Management of Migraine and Arthritis.
Authors: Siddiqui Tayyaba , Anas Muhammad , Zaidi Syed Zahoor Ul Hassan
Published: August 2024

Unani medicine, rooted in Greco-Arabic traditions, offers a holistic approach to healthcare, focusing on the balance of bodily humors and natural medications from plants, minerals, and animals. Unani medicine's holistic perspective emphasizes comprehensive care by addressing the root causes of diseases, particularly in chronic conditions like cancer and neurological disorders. The system's emphasis on Mizaj, preventive measures, and health promotion reflects its relevance in contemporary healthcare. Integrating traditional knowledge with modern scientific validation, Unani medicine offers valuable insights into alternative approaches to health management. This review article explores the management of migraine and arthritis using Unani medicine, drawing insights from various case reports. The objective is to evaluate the efficacy of Unani treatments in providing relief and improving the quality of life for patients suffering from these conditions. The review analyzes multiple case reports detailing the use of specific Unani formulations and therapies. Key findings indicate that Unani medicine, with its holistic approach and reliance on natural medications, has shown promising results in managing both migraine and arthritis. Unani medicine offers a valuable alternative approach to managing migraine and arthritis, aligning traditional knowledge with modern therapeutic needs.
Crowning “heartbeat mastery”: unraveling the secrets of the circulatory system in Cesareo Villa Abrille Elementary School - Schools Division of Davao City
Authors: Ceria Marivic
Published: August 2024

This action research study delves into enhancing the grasp of circulatory system among Grade 6 pupils of Cesareo Villa Abrille Elementary School- Schools Division Office of Davao City, through the integration of instructional materials named "Heartbeat Mastery” during S.Y. 2023-2024. It evaluated the efficacy of incorporating these materials into elementary science education, employing a robust methodology encompassing participant selection, teaching interventions, and data collection. This study employed a quasi-experimental pre-test/post-test design. Results indicate significant enhancements in learners' comprehension of the circulatory system and cardiovascular concepts post-intervention. Results revealed that the impact of integrating instructional materials, specifically "Heartbeat Mastery,” aligns with Bloom's Taxonomy, addressing cognitive needs and enhancing understanding of the circulatory system showing significant improvements in pupils’ comprehension and mastery. The findings underscore the effectiveness of the intervention in bridging knowledge gaps and enhancing students' understanding of cardiovascular science concepts.
Capacidades analíticas y gobernanza de datos en la administración pública como paso previo a la introducción de la inteligencia artificial
Authors: Salvador Miquel , Ramió Carles
Published: August 2024

In order to face the challenges associated with the so-called revolution 4.0 and the digital transformation, it is critical to rethink the capacities that public organizations have. Among these capacities, those associated with management and data analysis stand out. The article aims to provide evidence and reflections to this debate, both at a theoretical and applied level. To this end, a conceptual framework is developed through two key approaches: that of analytical capacities, focusing on the organizational and systemic level, and that of data governance. With the integrated analytical framework, the case study of Barcelona City Council is carried out. This case includes different initiatives that provide evidence and arguments both on the achievements and on the unresolved challenges. The main findings that arise from the analysis are the importance of the strategy associated to a political and managerial leadership, as well as the relevance of the organizational configuration and the establishment of roles and responsibilities of the different actors involved. Additionally, the need to establish new models of relationship with the environment to generate shared institutional intelligence, associated to open learning and innovation processes, is highlighted. The conclusions highlight the validity of analytical schemes that integrate data governance with the development of analytical capacities that allow public administrations to face of future challenges. At the applied level,
lessons learned are provided in relation to the organizational leadership of the transformation processes of public organizations. A special attention is given to the design of the central data governance unit which combines centralization at the conceptual and strategic level and the decentralization at the operational level, involving both internal and external actors.
Operation of Czechoslovak Military Intelligence in Austria. Part 2 (Origin of the Legal Mixed “Průsek” Residency and its Activity in 1976–1989)
Authors: Púčik Miloslav
Published: August 2024

The second part of the study builds on the previous first part by focusing on the period of the second half of the 1970s. During this period, the “Průsek” Residency, which was a mixed residency type, started operating in the area of interest. The paper analyses the early days of its activities, which were marked by problems in recruitment and information outreach. It highlights the difficulties in building an agency network and penetrating the identified main and auxiliary objects of interest.
COMPENSAÇÃO DE CRÉDITOS TRIBUTÁRIOS E RESPONSABILIDADE SOCIAL CORPORATIVA
Authors: Martins Larissa Fernanda Silva
Published: August 2024

This article explores the intersection between tax credit compensation and corporate social responsibility (CSR) in the United States. Tax credit compensation is a financial strategy that allows companies to optimize their tax liabilities, while CSR focuses on sustainable and socially responsible business practices. This study examines how integrating these two approaches can benefit both companies and society. We analyze cases of companies that have successfully implemented these strategies and discuss the legal and ethical implications involved. Furthermore, we highlight the role of public policies in facilitating responsible tax practices that promote sustainable development and social welfare.
Business education skills expected of graduates of office technology and management (OTM) program for economic growth and development
Authors: Obayi Anthonia U. , Onyekwere Gift C. , Ikechukwu Juliet Onyekwere
Published: August 2024

Business education skills expected of graduates of office technology and management (OTM) program for economic growth and development
Inadequacies of project management skills of secretaries: implications for OTM curriculum reorganization
Authors: Ifesi Cecilia , Asogwa Sylvester O. , Bala Abdallahi Doya
Published: August 2024

Inadequacies of project management skills of secretaries: implications for OTM curriculum reorganization
Helicobacter Pylori: Beyond The Gut - Insights Into Its Association With Dermatological Conditions
Authors: Bhatt Deepa
Published: August 2024

Introduction: Helicobacter pylori (H. pylori) is a Gram-negative bacterium associated with gastrointestinal diseases and extra-gastrointestinal manifestations, including dermatological conditions. Understanding the precise mechanisms and clinical implications of the H. pylori skin disorder association is essential. Materials and methods: A cross-sectional observational study was conducted at a private dermatology center in Ahmedabad, Gujarat, from January 2021 to August 2023. Patients coming with various dermatological conditions and with suspected H. pylori infection underwent clinical examination, laboratory tests, and skin biopsy to confirm the diagnosis of disease. The statistical analysis assessed associations between demographics, dermatological conditions, and H. pylori antibody test results. Laboratory Investigation: H. pylori antibody levels were measured using serology by doing H.pylori IgG antibody level testing and cut-off values of >0.90 were considered positive. Statistical Analysis: Data entry and analysis involved Microsoft Excel 360, calculating proportions, and percentages, and drawing appropriate inferences. Results: Of 1131 enrolled patients (male-female ratio 1:1.43), 22% tested positive for H. pylori, with higher positivity rates in patients aged >60 years and 40-60 years. Analysis revealed varying proportions of H. pylori positivity across dermatological conditions, with alopecia areata and chronic urticaria showing the highest rates. Conclusions: While studies suggest H. pylori’s involvement in dermatological diseases, further research is needed to understand this relationship fully. Systematic investigations into the impact of eradication therapy are essential to inform clinical management strategies and guide future research directions.
A Critical Review of Law No. 3-2006 on Assets and Property Declaration in Cameroon
Authors: Ashukem Jean-Claude
Published: August 2024

The adoption in 2006 of a law relating to the declaration of assets and property in Cameroon indicates and represents a new hope for the practical implementation of article 66 of the Constitution of the Republic of Cameroon. This article uses the doctrinal research methodology approach to critically assess Cameroon’s Law No.3-2006 as an anti-corruption mechanism. Based on this assessment, I essentially argue and clarify that despite the noble intention of welcoming its adoption, there are inherent weaknesses including a continuous challenge to implementing or operationalising the law, the non-existent of the Assets and Property Declaration Commission. Furthermore, assets and property disclosure is still contemplated as a secret and the fact that the envisaged sanctions for non-compliance with assets and property declaration requirements do not constitute a sufficient deterrent to corruption. I conclude by proffering suggestions for improving the legal framework as a credible anti-corruption strategy.
The Impact of Corruption on Civil and Political Rights under ICCPR (International Covenant on Civil and Political Rights 1966)
Authors: Alkubaisy Ali
Published: August 2024

Corruption, a pervasive and destructive phenomenon, has far-reaching implications for civil and political rights. This paper examines corruption’s legal effects on civil and political rights, focusing on the International Covenant on Civil and Political Rights (ICCPR) 1966. It also studies corruption and the ICCPR 1966 to highlight the challenges and legal solutions to fighting corruption while protecting civil and political rights. The conceptual framework explains corruption, civil and political rights, and the ICCPR 1966. Corruption, the abuse of power for personal gain, undermines the principles of the ICCPR 1966, such as freedom of expression, political participation, fair and impartial judiciary, and access to effective remedies. This study shows how corruption affects these rights and democratic institutions, public trust, and good governance. The instances of Brazil’s Operation Car Wash and Ukraine’s Euromaidan Movement serve as influential case studies, demonstrating the damaging impact of corruption on civil and political rights. Furthermore, this study analyzes legal strategies and outcomes in combating corruption. It emphasizes international cooperation, judicial transparency, preventative measures, and surveillance and prosecutorial capabilities. Operation Car Wash in Brazil and the Ukrainian anti-corruption reforms are effective anti-corruption and civil rights endeavors. The ICCPR 1966 and The United Nation Convention against Corruption (UNCAC) are also examined in the research. Regional and national instruments show the multi-layered strategy needed to fight corruption and preserve civil and political rights. This study’s findings provide policy suggestions for protecting political and civil liberties from the corrupt government. There is a call to action to improve legal frameworks, increase judicial independence and accountability, foster a culture of integrity and ethics, empower civil society and the media, guarantee effective remedies, and implement international instruments.
Transfusion-associated necrotising enterocolitis in very low birth weight babies: transfusion and feeding practices in two neonatal units in Bloemfontein, Free State
Authors: Brits E , Kruger I , Joubert G
Published: August 2024

Background. Necrotising enterocolitis (NEC) is life-threatening with a rising incidence due to improved neonatal care. While researchers’ focus has shifted to causes, risk factors and preventative clinical strategies, little is known about the exact aetiology of NEC. Risk factors include the relationship between red blood cell transfusions (RBCTs) and the development of transfusion-associated NEC (TANEC) and peri-transfusion feeding, increasing the risk of TANEC.
Objectives. Evaluate the relationship between RBCT and peri-transfusion feeding practices and the development of TANEC in very low birthweight (VLBW) neonates over 5 years.
Methods. This was a retrospective analytical record review of all VLBW neonates admitted to two tertiary hospitals’ neonatal units in Bloemfontein, South Africa (SA), from 1 January 2012 - 31 December 2016.
Results. The study population (n=1 426) had a median birthweight of 1 260 g and a median gestation age of 30 weeks. RBCTs were given to 41.9%, and NEC developed in 7.4%, of whom 47.6% had an RBCT (TANEC). Half (47.2%) were kept nil per os (NPO) around the transfusion. No association was found between NPO status and TANEC development (8.9% NPO patients, 7.9% non-NPO patients, p=0.6826). No significant differences regarding Modified Bell’s Staging were found between neonates who developed TANEC v. NEC.
Conclusion. Optimising the administration of RBCTs and evidence-based feeding protocols is crucial in reducing TANEC’s impact on premature neonates.
Co-Authorship Trends in Philosophy of Education Journals in the US and Canada
Authors: Taylor Rebecca M. , Lee Seunghyun , Murphy Brust Caitlin
Published: August 2024

A variety of epistemic practices and norms influence how knowledge and understanding are advanced in academia. Co-authorship practices and norms, the focus of this paper, have implications for the epistemic resources that are brought into individual scholarly works and how the resources are distributed among networks over time. Although co-authorship is widely accepted in social scientific research in education, single authorship has remained predominant in philosophy of education. This paper is part of a project exploring co-authorship practices and norms in philosophy and, in particular, philosophy of education. We aim to develop an empirical understanding of co-authorship trends in four primary philosophy of education journals in the United States and Canada. We examine the frequency of co-authorship in these outlets over the last two decades, the participants in co-authored projects, and the philosophical topics that are being explored through co-authorship. Our findings indicate that these venues are publishing co-authored works with increasing frequency and that most co-authorship is happening among faculty collaborators and among scholars who share common disciplinary backgrounds. The observed increase in the practice of co-authorship in these philosophy of education journals points to the significance of exploring it in greater depth, including giving attention to questions of ethics and epistemology that co-authorship raises, as well as to comparative analyses of trends around the world.
The Confucian Concept of Learning and the Aesthetics of Human Experience: An Eco-Ontological Interpretation
Authors: Meyer David Samuel
Published: August 2024

This paper examines the Confucian concept of learning, or xue (學) , from the perspective of ecological humanism. Through a comparative interpretation, this paper attempts to disclose the significance of Confucian xue conceived as a practice of aesthetic appreciation and creativity, emphasizing in particular its function within an eco-centric worldview. The author reviews the relevant concepts of ecological humanism as expressed in the ideas of John Dewey and Thomas Alexander, then applies these as a theoretical framework for interpreting xue and its related concepts and practices as they appear in the Confucian text the Lunyu (論語). It is argued that xue is a process of developing and expressing virtuosity and artistry in the “arts of life,” and that its practice was understood as a direct participation in the creative development of nature. The significance of such a concept of learning for contemporary educational philosophy is discussed in conclusion.
Improved inference of population histories by integrating genomic and epigenomic data
Authors: Sellinger Thibaut , Johannes Frank , Tellier Aurélien
Published: August 2024

With the availability of high quality full genome polymorphism (SNPs) data, it becomes feasible to study the past demographic and selective history of populations in exquisite detail. However, such inferences still suffer from a lack of statistical resolution for recent, e.g. bottlenecks, events, and/or for populations with small nucleotide diversity. Additional heritable (epi)genetic markers, such as indels, transposable elements, microsatellites or cytosine methylation, may provide further, yet untapped, information on the recent past population history. We extend the Sequential Markovian Coalescent (SMC) framework to jointly use SNPs and other hyper-mutable markers. We are able to 1) improve the accuracy of demographic inference in recent times, 2) uncover past demographic events hidden to SNP-based inference methods, and 3) infer the hyper-mutable marker mutation rates under a finite site model. As a proof of principle, we focus on demographic inference in
A. thaliana
using DNA methylation diversity data from 10 European natural accessions. We demonstrate that segregating Single Methylated Polymorphisms (SMPs) satisfy the modelling assumptions of the SMC framework, while Differentially Methylated Regions (DMRs) are not suitable as their length exceeds that of the genomic distance between two recombination events. Combining SNPs and SMPs while accounting for site- and region-level epimutation processes, we provide new estimates of the glacial age bottleneck and post glacial population expansion of the European
A. thaliana
population. Our SMC framework readily accounts for a wide range of heritable genomic markers, thus paving the way for next generation inference of evolutionary history by combining information from several genetic and epigenetic markers.
Metabolic heterogeneity of colorectal cancer as a prognostic factor: insights gained from fluorescence lifetime imaging
Authors: Komarova Anastasia D , Sinyushkina Snezhana D , Shchechkin Ilia D , Druzhkova Irina N , Smirnova Sofia A , Terekhov Vitaliy M , Mozherov Artem M , Ignatova Nadezhda I , Nikonova Elena E , Shirshin Evgeny A , Shimolina Liubov E , Gamayunov Sergey V , Shcheslavskiy Vladislav I , Shirmanova Marina V
Published: August 2024

Heterogeneity of tumor metabolism is an important, but still poorly understood aspect of tumor biology. Present work is focused on the visualization and quantification of cellular metabolic heterogeneity of colorectal cancer using fluorescence lifetime imaging (FLIM) of redox cofactor NAD(P)H. FLIM-microscopy of NAD(P)H was performed in vitro in four cancer cell lines, in vivo in the four types of tumors in mice and ex vivo in patients’ tumor samples. The dispersion and bimodality of the decay parameters were evaluated to quantify the intercellular metabolic heterogeneity. Our results demonstrate that patients’ tumors have significantly higher heterogeneity of energy metabolism compared with cultured cells and tumor xenografts, which was displayed as a wider and frequently bimodal distribution of a contribution of a free (glycolytic) fraction of NAD(P)H within a sample. Among patients’ tumors, the dispersion was larger in the high-grade and early stage ones, without, however, any association with bimodality. These results indicate that cell-level metabolic heterogeneity assessed from NAD(P)H FLIM has a potential to become a clinical prognostic factor.
Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans
Authors: Jiang Yixuan , Zhao Fujie , Liang Ying , Lu Zhenguo , Wang Siyu , Meng Yao , Liu Zhanxiang , Zhang Jing , Zhao Youbao
Published: August 2024

Rtf1 is generally considered to be a subunit of the Paf1 complex (Paf1C), which is a multifunctional protein complex involved in histone modification and RNA biosynthesis at multiple stages. Rtf1 is stably associated with the Paf1C in
Saccharomyces cerevisiae
, but not in other species including humans. Little is known about its function in human fungal pathogens. Here, we show that Rtf1 is required for facilitating H2B monoubiquitination (H2Bub1), and regulates fungal morphogenesis and pathogenicity in the meningitis-causing fungal pathogen
Cryptococcus neoformans
. Rtf1 is not tightly associated with the Paf1C, and its histone modification domain (HMD) is sufficient to promote H2Bub1 and the expression of genes related to fungal mating and filamentation. Moreover, Rtf1 HMD fully restores fungal morphogenesis and pathogenicity; however, it fails to restore defects of thermal tolerance and melanin production in the
rtf1
Δ strain background. The present study establishes a role for cryptococcal Rtf1 as a Paf1C-independent regulator in regulating fungal morphogenesis and pathogenicity, and highlights the function of HMD in facilitating global H2Bub1 in
C. neoformans
.
Localization of potato browning resistance genes based on BSA-seq technology
Authors: Wang Haiyan , Pang Ze , Wang Lichun , Tian Guokui , Li Fengyun , Pan Yang , Ding Kaixin
Published: August 2024

Browning is a common problem that occurs during potato processing; it is typically resolved by adding chemicals during the production process. However, there is a need to develop potato varieties that are resistant to browning due to a growing consumer interest in healthier diets. This study initially identified 275 potato varieties that are resistant to browning; these were narrowed down to eight varieties, with four of them being highly resistant. A hybrid population was developed by crossing the highly resistant CIP395109.29 with the easily browned Kexin 23. Bulked segregant analysis (BSA) was conducted, which identified 21 potato genes associated with anti-browning properties through sequencing data analysis and organization. The findings of this study lay a solid groundwork for future research on breeding potatoes with anti-browning traits, offer molecular markers for identifying anti-browning varieties, and serve as a valuable reference for further investigations into potato browning mechanisms.