bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGENTASAN MASALAH SOSIAL MELALUI PEOPLE CENTERED DEVELOPMENT GUNA MEMAKSIMALKAN PEMBANGUNAN DI INDONESIA
Authors: Fernandya Saskia , Yuwono Teguh , Al-Firdaus Laila Kholid
Published: November 2022

People centered development, begins with an understanding of human ecology, which is the center of development attention. Development must place the people at the center of attention and the development process must benefit all parties. Therefore, this study aims to provide an effective understanding related to alleviating social problems through people centered development in order to maximize development. This study uses a literature review research method. The results of the study indicate that large-scale changes in this global era, it can be said that human development is actually faced with complex problems and dilemmas. So, it is necessary to develop Human Resources, such as empowerment in order to improve human quality. This people-centered development model is a new alternative to increase the production output of development to meet the needs of a very large and growing population. Along with today's global development, it must be fully understood that human development is an important agenda with more the amount of attention related to human rights, democratization and civil society. This needs to be taken seriously by the central and local governments in the form of development policies that truly place the community as development actors.AbstrakPeople centered development atau pembangunan yang berpusatkan pada rakyat, diawali dengan pemahaman tentang ekologi manusia, yang menjadi pusat perhatian pembangunan. Pembangunan haruslah menempatkan rakyat sebagai pusat perhatian dan proses pembangunan harus menguntungkan semua pihak. Oleh sebab itu, penelitian ini bertujuan untuk memberikan pemahaman yang efektif terkait pengetasan masalah sosial melalui people centered development guna memaksimalkan pembangunan. Penelitian ini menggunakan metode penelitian studi literatur (literature review). Hasil penelitian menunjukkan bahwa perubahan secara besar-besaran pada era global ini, dapat dikatakan bahwa pembangunan manusia sebenarnya dihadapkan pada permasalahan yang pelik dan dilematis. Maka, diperlukan pengembangan Sumber Daya Manusia, seperti pemberdayaan guna meningkatkan kualitas manusia. Model pembangunan yang berpusat pada rakyat (People Centered Development) ini, adalah suatu alternatif baru untuk meningkatkan hasil produksi pembangunan untuk memenuhi kebutuhan penduduk yang sangat banyak dan terus bertambah Seiring dengan pembangunan global dewasa ini, harus dipahami sepenuhnya bahwa pembangunan manusia menjadi agenda penting dengan semakin besarnya perhatian yang berkaitan dengan Hak Asasi Manusia, demokratisasi dan civil society. Hal ini, perlu direspon dengan serius oleh pemerintah pusat maupun daerah dalam bentuk kebijakan pembangunan yang sungguh-sungguh menempatkan masyarakat sebagai pelaku pembangunan.
PERAN PEMERINTAH DESA DALAM PEMBERDAYAAN KELOMPOK INFORMASI MASYARAKAT
Authors: Chornelia Roro Merry , Fithriana Noora , Rohman Abd.
Published: November 2022

Empowerment can be said as a process of building a community through capacity building and behavior change in an organization. The purposes of this research are to determine the role of rural government to empower the information group of societies in the village of Tlekung, Bumiaji, Batu; its supporting and inhibiting factors. This research used a qualitative approach to obtain the primary and secondary data. The research results determined that the Rural Government of Tlekung plays the role successfully so the group can inform many pieces of information in Tlekung by the media. To conduct the job, the Rural Government of Tlekung also gives incentives to the group and controls its activities. The supporting factor of the role of the Rural Government of Tlekung for empowering the group is a good communication style; meanwhile, the inhibiting factor is a fund that lacks to buy some media tools. AbstrakPemberdayaan dapat dikatakan sebagai suatu proses membangun masyarakat melalui pengembangan kemampuan dan perubahan perilakunya dalam suatu organisasi. Tujuan dilakukannya penelitian ini adalah untuk mengetahui peran pemerintah desa dalam pemberdayaan kelompok informasi masyarakat di Desa Tlekung, Kecamatan Bumiaji, Kota Batu, faktor pendukung dan penghambatnya. Penelitian ini menggunakan pendekatan kualitatif untuk memperoleh data primer dan sekunder. Hasil penelitian menunjukkan bahwa Pemerintah Desa Tlekung berhasil berperan dalam pemberdayaan KIM sehingga KIM dapat memberitahukan hal-hal yang sedang dan akan dilaksanakan di Desa Tlekung melalui media-media informasi. Dalam menjalankan perannya, Pemerintah Desa Tlekung juga memberikan insentif kepada KIM dan mengontrol kegiatan KIM. Faktor pendukung peran Pemerintah Desa Tlekung dalam pemberdayaan KIM adalah pola komunikasi yang baik, sedangkan faktor penghambatnya ialah kurangnya dana untuk membelikan peralatan media.
KOLABORASI MULTI AKTOR DALAM PENGELOLAAN WISATA GEO PARK BELITUNG
Authors: Pujiyono Bambang
Published: November 2022

This study aims to describe the collaboration of multi-actor in managing tourism GeoPark Belitung. This tourism management has succeeded in bringing the Belitung GeoPark into the UNESCO assessment as one of the international tourism destinations. Various actors, both from the government, private sector, and community, have contributed greatly. Contributions are given in accordance with the roles and functions. Each institution cooperates, communicates, and coordinates so as to build good collaboration. This research uses a qualitative approach, aiming to explain the phenomenon of GeoPark tourism management even in the pandemic era. The research lasted for 2 months from November to December 2020. There were 10 research resource persons from government, private and community elements who represented the institution. The research results provide in-depth information on successful collaborative practices. The results of this study provide a conceptual contribution to multi-actor collaboration in the field of tourism management.AbstrakPenelitian ini bertujuan mendiskripsikan kolaborasi multi actor dalam mengelola pariwisata GeoPark Belitung. Pengelolaan pariwisata ini berhasil mengantarkan GeoPark Belitung masuk dalam penilaian UNESCO sebagai salah satu destinasi pariwisata internasional. Berbagai actor baik dari unsur pemerintah, swasta, dan komunitas memiliki kontribusi yang besar. Kontribusi yang diberikan sesuai dengan peran dan fungsi. Tiap lembaga melakukan kerjasama, komunikasi, dan koordinasi sehingga membangun kolaborasi yang baik.. Penelitian ini menggunakan pendekatan kualitatif, bertujuan mengeksplanasi fenomena pengelolaan pariwisata GeoPark meskipun di era pandemi. Penelitian berlangsung selama 2 bulan dari Nopember sampai dengan Desember 2020. Nara sumber penelitian dari unsur pemerintah, swasta, dan komunitas sebanyak 10 orang yang merepresentasi lembaganya. Hasil penelitian menunjukkan bahwa pengelolaan wisata geopark dilakukan oleh pemerintah, swasta, dan masyarakat. Tiap lembaga memiliki sekaligus melaksanakan otoritas dan perannya. Secara umum ketiga lembaga tersebut memiliki kesamaan komitmen untuk menjaga pelesatarian Geopark. Tiap lembaga memiliki kepentingan, pengaruh, dan kekuatan. Secara komparatif, lembaga pemerintah dalam hal ini Dinas Pariwisata memiliki dominansi dibandingkan lembaga swasta dan komunitas yang ada. Hasil penelitian ini sekaligus menggambarkan kolaborasi multiaktor yang berhasil.
PEMBERDAYAAN PEREMPUAN KORBAN KEKERASAN DALAM RUMAH TANGGA (KDRT) OLEH DINAS PEMBERDAYAAN PEREMPUAN, PERLINDUNGAN ANAK DAN KELUARGA BERENCANA (DP3AP2KB) KOTA BATU
Authors: Bagus Nanang
Published: November 2022

The purpose of marriage does not always run smoothly, there are times when trials and temptations lead to acts of violence by husband/wife. The purpose of this study is to explain the empowerment of women victims of domestic violence conducted by DP3AP2KB Batu City and the role of women's empowerment in the household economy. The type of research used is descriptive qualitative. The method of determining the research subject is purposive sampling and recommendations. Data collection techniques using participatory observation methods, in-depth interviews, and documentation. Data analysis used the Miles and Huberman model, namely data reduction, data presentation and conclusion drawing/verification. The result showed that women's empowerment was realized through two activities, namely mentoring (socialization, health checks, problem classification, mentoring to monitoring/monitoring) and social welfare efforts (cooking training, make-up/salon and sewing). The role of women's empowerment in the household economy is quite significant. This is evident from the work they live is capable of helping their husbands in meeting the needs of their families. These jobs include making cakes, tailoring and so on.AbstrakTujuan dari pernikahan tidak selamanya berjalan mulus, ada kalanya cobaan dan godaan hingga berujung pada tindak kekerasan yang dilakukan suami/istri. Tujuan penelitian ini untuk menjelaskan pemberdayaan perempuan korban KDRT yang dilakukan DP3AP2KB Kota Batu dan peran pemberdayaan perempuan dalam perekonomian rumah tangga. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Metode penentuan subyek penelitian yaitu purposive sampling dan rekomendasi. Teknik pengumpulan data menggunakan metode observasi partisipasi, wawancara mendalam, dan dokumentasi. Analisis data menggunakan model Miles and Huberman yaitu reduksi data, penyajian data dan conclusion drawing/ verification. Hasil penelitian menunjukkan bahwa pemberdayaan perempuan terwujud melalui dua kegiatan yaitu pendampingan (sosialisasi, pemeriksaan kesehatan, klasifikasi masalah, pendampingan hingga pemantauan/monitoring) dan usaha kesejahteraan sosial (pelatihan tata boga, tata rias/salon dan menjahit). Peran pemberdayaan perempuan dalam perekonomian rumah tangga yaitu cukup signifikan. Hal ini terbukti dari pekerjaan yang mereka jalani mampu menghasilkan membantu suami dalam memenuhi kebutuhan keluarganya. Pekerjaan tersebut antara lain membuat kue, penjahit dan lain sebagainya.
Infectious disease threats to amphibians in Greece: new localities positive for Batrachochytrium dendrobatidis
Authors: Strachinis I , Marschang RE , Lymberakis P , Karagianni KM , Azmanis P
Published: November 2022

In the early 2000s, numerous cases of European amphibian population declines and mass die-offs started to emerge. Investigating those events led to the discovery that wild European amphibians were confronted with grave disease threats caused by introduced pathogens, namely the amphibian and the salamander chytrid fungi Batrachochytrium dendrobatidis (Bd) and B. salamandrivorans (Bsal) and ranaviruses. In Greece, Bd was previously documented among wild amphibian populations in 2 different locations and 3 different species. However, no disease-related mass declines or mortality events have been reported. In this work, we build upon previous findings with new, subsequently obtained data, resulting in a 225-sample dataset of 14 species from 17 different locations throughout Greece, in order to examine the occurrence status of all 3 pathogens responsible for emerging infectious diseases in European amphibians. No positive samples for Bsal or ranavirus were recorded in any location. We confirmed the presence of Bd in 4 more localities and in 4 more species, including 1 urodelan (Macedonian crested newt Triturus macedonicus) and 1 introduced anuran (American bullfrog Lithobates catesbeianus). All insular localities were negative for Bd, except for Crete, where Bd was identified in 2 different locations. Again, no mass declines or die-offs were recorded in any Bd-positive area or elsewhere. However, given the persistence of Bd across Greece over the past ~20 yr, monitoring efforts should continue, and ideally be further expanded.
The Effect of Cooperative Model Type Team Assisted Individualization (TAI) on Student Learning Outcomes in Integrated Thematic Learning
Authors: Putri Sonia Dwi Permata , Fitria Yanti
Published: November 2022

The main objective of this study is to identify the impact of Team Assisted Individualization models on the academic results of primary school students on the topic "environment is our best friend." The above research was quantitative and employs a quasi-experimental situation design. The design of a non-equivalent Control Group is being used in the study. The grouping sampling method had been used to sample the population, which was composed of 3 SD in Cluster I, Kec. IV, Jurai. The study was undertaken at Class VA had 16 students in it as an experiment group and Class VB had 15 students in it as a control group. Preconditioned test results in the form of normality, homogeneity tests, and hypothetical tests using the t-test were also used to analyze the data for this research. The experimental class's pre-test average was 46,25, and the post-test average was 80,5 after implementing the Team Assisted Individualization learning models. Meanwhile, after being taught using the traditional approach of 64,13, the control class received an average of 49,06 There is a pre-test and a post-test. Then there's the t-test both had a significant level of 0,05. This ttable = 2,045 > tcount = 3,605. It can be concluded that the Team Assisted Individualization model has an impact on students' learning outcomes when it comes to the topic "environment is our best friend.
Development of Kvisoft Flipbook Maker Media on Integrated Thematic Learning in Fifth Grade of Elementary School
Authors: Reinita Reinita , Saralee Adelweiss
Published: November 2022

This research is motivated by the unavailability of varied and monotonous learning media. This results in a conventional learning situation where learning is only centered on the teacher and students only get information. and also caused by the lack of creativity of teachers in building interesting learning media. This study aims to develop a Kvisoft Flipbook Maker media based on a scientific approach in integrated thematic learning in grade V Elementary School that is valid and practical. This type of research is development using the ADDIE model. The product developed is the Kvisoft Flipbook Maker media based on a scientific approach in Theme 8 (Our Friendly Environment) sub-theme 1 (Humans and the Environment) Learning 3 and 4. The results of the practicality test can be seen in the questionnaire responses of students and teachers. Where the overall student response questionnaire as many as 10 people is 97% in the very practical category and the teacher's questionnaire response is 95.7% in the very practical category. Thus, the Kvisoft Flipbook Maker media based on a scientific approach is declared practical to be used in learning activities.
Tourism Objects as Social Studies Learning Sources in Elementary School
Authors: Rachmadyanti Putri , Mahananingtyas Elsinora , Ariyanti Lita
Published: November 2022

Objects tourism in premises increasingly growing and provide impacts positively on the economy of the community. The existence of tourist attractions can also contribute to the world of education, especially as a source of learning. Purpose research is the exploration use of tourism attractions in learning in Elementary School Education. The method of research that is used is research qualitative study of the case. The data collection technique used two steps, namely questionnaires and semi-structured interviews. The participants were 89 elementary school teachers in 6 cities of East Java who filled out a questionnaire and 12 people were willing to do semi-structured interviews. The findings in this study are 59% of teachers use the type of natural tourism object in learning, 55% of teachers choose tourism objects based on teaching materials, 55% of teachers use tours to make learning more fun, and 52% of teachers explain the obstacles to learning by utilizing these attractions come from costs. The study is expected to give a contribution positive to the development of learning that is based on experience in the School Elementary with tourism objects. This study also emphasizes the importance of providing effective learning resources for social studies learning in elementary schools.
English Teachers’ Perspectives of Learner Autonomy in Online Reading Comprehension in Times of the COVID-19 Pandemic
Authors: Stevani Margaret , Ginting Fiber Yun Almanda
Published: November 2022

The objectives of this research were focused on English teachers’ perspectives on learner autonomy and to what extent do English teachers feel their learners are autonomous in online reading comprehension in times of the COVID-19 pandemic. These research questions were answered by using observation, interview, and Likert-scale questionnaire in the form of qualitative method. The sample of this study was 26 English teachers in 4 elementary schools and 5 junior high schools in North Sumatra, Indonesia. The results of the study showed some points on learner autonomy, such as: (1) the importance of learner autonomy, (2) the way English teachers promoted learner autonomy, (3) the challenges of English teachers to implement learner autonomy, (4) English teachers’ responsibility in online reading comprehension, (5) English teachers’ observation to learners’ autonomy in online reading comprehension, (6) learners’ activities in online reading comprehension strategy, (7) English teachers’ preparation in online reading comprehension class. This research concluded that the degree of learners’ autonomy during the pandemic was higher rather than before the COVID-19 pandemic due to some reasons.
Implementing of the BOPPS Model on Basic Properties of Fractions Using Hawgent Dynamic Mathematics Software in Elementary Education
Authors: Zhuoya Wen , Tang Jianlan
Published: November 2022

The rapid development of information technology, informationization of education has become inevitable. Starting from the necessity of information-based teaching, this paper introduces the basic structure of the BOPPPS model and analyzes the content of each stage of the model. On this basis, the BOPPPS model is applied to the teaching of basic properties of fractions with the help of Hawgent dynamic mathematics software, in order to provide a theoretical basis for teachers to improve the teaching and methods of elementary mathematics, enhance the efficiency of classroom teaching, and help the implementation of "double reduction".
DETERMINATION OF COAL RANKING BASED ON MACERAL ANALYSIS IN TANJUNG BELIT REGION, DHARMASRAYA REGENCY, WEST SUMATERA PROVINCE
Authors: Trianda Obrin , Tedja Trisnaning Paramitha , Prastowo Rizqi , Helmi Hurien
Published: November 2022

Daerah penelitian berada pada Desa Tanjung Belit, Kabupaten Dharmasraya, Sumatera Barat yang termasuk dalam Cekungan Sumatera Selatan, Sub-Cekungan Jambi. Metode penelitian berupa pemetaan dan pengambilan conto sampel batubara yang dilakukan sebagai dasar analisa maseral dan piroksimat. Berdasarkan dari hasil analisis maseral, pada daerah penelitian dapat dibedakan menjadi dua seam batubara, yaitu Seam A dan Seam B. Hasil analisis RV (Refletan Vitrinite), Seam A batubara mempunyai nilai 0,47% yang menunjukkan hasil kalori batubara seam A berupa High Volatile Bituminous C. Seam B memiliki nilai RV sebesar 0,39% – 0,46% yang menunjukkan nilai kalori berupa Sub Bituminous.  Hasil analisis maseral Seam A dan Seam B memiliki perbedaan yang cukup besar dalam kelompok inertinite, yaitu: Seam A memiliki nilai inertinte 3,0% – 4,4% dan Seam B memiliki nilai inertinte 12% – 18.8%. Nilai vitrinite tinggi mencirikan pembentukan batubara pada kelompok ini berasal dari tumbuhan yang telah terbakar dan sebagian besar berasal dari proses oksidasi maseral lainya (dexarboxylaction). Proses oksidasi maseral terjadi disebabkan oleh bakteri dan jamur, sehingga akan meningkatkan abu dan sulfur pada suatu batubara.
GEOLOGY AND ORE CHARACTERISTICS OF LOW SULFIDATION EPITHERMAL GOLD MINERALIZATION AT TAMBANG SAWAH, LEBONG, BENGKULU PROVINCE
Authors: Muhammad Muhsin Al Hakim  , Idrus Arifudin , Suryanto Wiwit
Published: November 2022

Abstract –– Tambang Sawah Area, Lebong Regency, Bengkulu Province, is geologically located in the Barisan mountains and Sumatra fault zone. The prospect of Tambang Sawah area lies in the physiography of the central Sumatran mountains ranges composed by the igneous rocks of the Sunda – Banda magmatic arc. This study is aimed to understand the deposit geology and ore characteristics of the gold deposit at the study area. Quartz vein mineralization of Tambang Sawah occurred in granite rock intruded into andesitic breccia rocks, with the geological structure of mineralization control in the form of joint, breccia, dike, and fault, namely the Ketahun fault that forms extentional fracture zones which were filled by hydrothermal fluid in form of quartz veins. Hydrothermal alterations that appear at the study site are typical types of alterations found in epithermal gold deposits, namely, argillic, silicified and propylitic. Sulfide minerals markers of low sulfidation epithermal type gold deposits found, namely, pyrite, calcopyrite, covelite, sphalerite and galena with colloform vein texture, cockade-crustiform, moss, and brecciated texture. Gold is interpreted to be derived from the deposition of sulfide minerals and the deposition of quartz veins, the level of gold in rocks and veins varies greatly with an average 4,8 ppm. Based on the results of ore geochemical analysis of positively correlated gold with elements Ag, Cu, Pb and Zn.

Keywords: Mineralization, low sulfidation epithermal gold, Tambang Sawah, Lebong, Bengkulu.
PENGGUNAAN PLUM MODEL DALAM ANALISIS PENGARUH FAKTOR PENGETAHUAN TERHADAP ATTITUDE DAN PRAKTEK PENGOLAHAN SAMPAH BERBASIS 3R
Authors: Ridayati  , A. Yunastiawan
Published: November 2022

Abstrak — Pengelolaan sampah rumah tangga merupakan isu penting dalam upaya menciptakan lingkungan permukiman yang berkelanjutan. Pengelolaan sampah rumah tangga memerlukan pola penanganan yang tepat. Upaya penerapan prinsip Reduce, Reuse, Recycle (3R) dalam pengelolaan sampah rumah tangga juga merupakan salah satu pendekatan yang populer di Indonesia. Kabupaten Sleman sebagai salah satu bagian dari Kawasan Perkotaan Yogyakarta (KPY) merupakan salah satu daerah yang berusaha menerapkan prinsip 3R dalam pengelolaan sampah rumah tangga. Penelitian ini menggunakan pendekatan studi kasus untuk mengukur hubungan antara pengetahuan tentang pengelolaan sampah rumah tangga berdasarkan prinsip 3R dengan sikap dan praktik yang dilakukan oleh masyarakat dalam pengelolaan sampah berbasis 3R di Kabupaten Sleman. Jumlah responden dalam penelitian ini adalah 300 responden yang merupakan kepala keluarga yang tinggal di Desa Sinduadi dan Sendangadi, Mlati, Kabupaten Sleman. Dataset dari hasil pengumpulan kuisioner diolah dengan menggunakan pendekatan Polytomous universal Model (PLUM) Model. Hasil penelitian menunjukkan bahwa ada hubungan antara aspek pengetahuan dengan sikap dan praktik masyarakat dalam pengelolaan sampah rumah tangga berbasis 3D.

Kata kunci: sampah rumah tangga, 3R, PLUM
A Look at Platelet Count in Chronic Hepatitis C Infection
Authors: Mihăilă Romeo-Gabriel
Published: November 2022

A complete blood count performed in chronic hepatitis C virus (HCV) infected patients can identify thrombocytopenia or an increased number of platelets, the cause of which must be established. Most of these patients are predisposed to develop thrombocytopenia as the disease progresses due to a lower thrombopoietin production, increased platelet pooling in the spleen, viral bone marrow suppression, or interferon-based therapy. However, a severe thrombocytopenia can have an autoimmune aetiology, which is very probable at values <15×103/mm3. Thrombopoietin analogues are useful both in patients with primary immune thrombocytopenia and in those who will begin the treatment with pegylated interferon and ribavirin before surgery. The common causes of an increased number of platelets in chronic HCV infected patients are splenectomy, ribavirin treatment, liver transplantation, and hepatocellular carcinoma. However, thrombocytosis can also be hereditary, reactive, or malignant, especially in essential thrombocythaemia or other myeloproliferative diseases that can be associated. A hepatic blood flow obstruction present in chronic HCV infected patients must draw attention to a possible associated myeloproliferative disorder (which frequently manifests in thrombocytosis) that represents its aetiology in two-thirds of cases and which can evolve with a constant or an intermittent increase in platelet count. The role of the JAK-STAT signalling mechanism is presented in both chronic hepatitis C patients and in those with essential thrombocythaemia. It was suggested that STAT3 could have a role in HCV RNA replication. In addition, the HCV core protein is involved in the modulation of fibrogenetic gene expression in hepatic stellate cells through a JAK2-STAT3 dependent pathway. Ruxolitinib (a JAK1/JAK2 inhibitor) can have beneficial effects in essential thrombocythaemia and is a subject of research in chronic hepatitis C. The discovery of the aetiology of thrombocytopenia or an increased number of platelets can contribute to a more complete diagnosis and appropriate treatment. The identification of associated disorders in chronic HCV infected patients is of vital importance for them.
A Discussion on the Management of Wilson Disease
Authors: Fricker Janet
Published: November 2022

Prof Peter Ferenci opened the meeting by providing a background to Wilson disease (WD), an enigmatic condition where no two cases are the same. He explored the aetiology, peak age of presentation, and long-term outlook.

Dr Gideon Hirschfield considered the wide variation in WD symptom presentation, the lack of a diagnostic gold standard, and the difficulties around choosing WD endpoints for clinical trials. He went on to consider how study endpoints have evolved over time, and how, in real-life clinical practice, therapies need to be tolerable for patients with negative copper balances.

Prof Anil Dhawan focussed on diagnostic challenges in paediatric WD, reviewing the size of liver biopsies needed for measurement of liver copper dry weight, the penicillamine challenge test, and Leipzig scores. Regarding treatment, he stressed that improvements in liver scores take time on chelation therapy, making it important not to rush patients to transplant. Prof Dhawan explored the development of disease severity scores for transplantation, including the revised cut-off points for the Nazer score. He provided reassuring data around the success of living related liver transplantation from parents heterozygous for WD and raised the possibility of auxiliary liver transplants.

Prof Karl Heinz Weiss considered three WD cases reflecting different aspects of the condition. The neurological case showed deterioration of neurological symptoms after starting D-penicillamine. This, Prof Weiss speculated, may relate to treatment causing shifts in the copper pool from bound copper to unbound copper. The second case involved a young woman with WD who was planning a pregnancy; Prof Weiss showed the importance of patients remaining with therapies they are used to. Finally, he considered a patient with decompensated cirrhosis referred for liver transplantation but for whom, when reassessed with the modified Nazer score, the level did not indicate the need for transplantation. The patient showed side effects with one treatment but subsequently did well on a second treatment and was delisted for transplant.
Welcome to the Real World: Hepatitis C Virus Clinical Trials to Patient Realities
Authors: Alieva Kabira
Published: November 2022

The symposium addressed the efficacy and safety of compounds currently available for treatment of hepatitis C virus (HCV) and chronic kidney disease (CKD) in North American and European countries, comparing data from trials and clinical practice. Prof Wedemeyer opened the meeting with a discussion of real-world experiences, with a focus on HCV genotypes (GTs) and resistance-associated variants (RAV). Prof Brown concentrated on trial and real-world data from patients with advanced liver disease, while Prof Craxí’s presentation focussed on chronic kidney conditions and infection. Prof Jacobson led the question and answer session and summarised the discussions.
Fatty Liver Disease: A Crosstalk Between Lipid Species
Authors: Martinez-Gili Laura , Garcia-Ruiz Carmen , Fernandez-Checa Carlos
Published: November 2022

The role of different lipid species such as free fatty acids and sphingolipids in non-alcoholic fatty liver disease (NAFLD) has been extensively studied during the last decade. In addition, free cholesterol accumulation in hepatocytes plays a crucial role in the transition from steatosis to steatohepatitis. However, the contribution of these lipids to NAFLD pathology is often evaluated individually. This review attempts to enclose the main metabolic and signalling connections between lipotoxic lipid species, and how their homeostasis is disrupted in NAFLD.
Hepatocellular Carcinoma. Part 1: Epidemiology, Risk Factors, Pathogenesis, and Pathology
Authors: Charach Lior , Zusmanovitch Lior , Charach Gideon
Published: November 2022

This review will cover the epidemiology, risk factors, pathogenesis, and pathology of hepatocellular carcinoma (HCC). HCC is the fifth most commonly diagnosed cancer in males and second most frequent cancer-related cause of mortality worldwide. In females, it is the seventh most frequently diagnosed malignancy and sixth leading cause of death. The incidence of HCC is higher among males in less developed countries and reaches a peak around the age of 70 years. The rates of liver cancer are twice as high in males compared to females.1,2 Various risk factors, including environmental, infectious, nutritional, and metabolic, are associated with HCC; among them viral infection has been linked to being the highest risk factor for developing HCC.

HCC is a highly vascular tumour and its pathogenesis consists of increasing angiogenesis by overexpression of various growth factors. Another cause of HCC development is thought to be mutations in different signalling pathways that lead to proliferation of the tumour cells.
APLIKASI PEMBELAJARAN INTERAKTIF “CALISTUNG” PADA ANAK USIA DINI MENGGUNAKAN SMARTPHONE ANDROID
Authors: Azali Bachrul , Latipah
Published: November 2022

Calistung merupakan kegiatan belajar dengan penguasaan baca, tulis, dan hitung yang merupakan kemampuan dasar yang harus dimiliki anak usia dini atau yang akan masuk ke sekolah dasar. Mengingat sangat pengtingnya kemampuan calistung, orang tua yang memiliki anak usia dini biasanya mengenalkan lebih awal dari usia seharusnya dengan harapan anak dapat cepat mengenal dan paham sehingga tidak perlu lama dalam proses pembelajaran. Salah satu pendekatan yang dapat digunakan untuk mengajarkan calistung adalah dengan menggunakan aplikasi yang berjalan pada smartphone. Dalam pengembangan aplikasi calistung ini menggunakan Flutter yang saat ini sedang banyak digunakan untuk pengembangan perangkat lunak berbasis mobile. Pengembangan aplikasi pembelajaran interaktif calistung berbasis Android memberikan tampilan yang lebih user friendly, mudah digunakan untuk anak usia dini, serta mudah diakses menggunakan smartphone Android yang ada dipasaran pada umumnya.
New liquid supports in the development of integrated platforms for the reuse of oxidative enzymes and polydopamine production
Authors: Magalhães Flávia F. , Pereira Ana F. , Freire Mara G. , Tavares Ana P. M.
Published: November 2022

Polydopamine (PDA), a bioinspired polymer from mussel adhesive proteins, has attracted impressive attention as a novel coating for (nano) materials with an adequate conformal layer and adjustable thickness. Currently, PDA is obtained from dopamine chemical oxidation under alkaline conditions, limiting its use in materials sensible to alkaline environments. Envisaging a widespread use of PDA, the polymerization of dopamine by enzymatic catalysis allows the dopamine polymerization in a large range of pHs, overcoming thus the limitations of conventional chemical oxidation. Moreover, the conventional method of polymerization is a time-consuming process and produces PDA films with poor stability, which restricts its applications. On the other hand, the main bottleneck of enzyme-based biocatalytic processes is the high cost of the single use of the enzyme. In this work, laccase was used to catalyse dopamine polymerization. To improve its performance, a liquid support for integrating the laccase and its reuse together with the PDA production and recovery was developed using aqueous biphasic systems (ABS). Firstly, dopamine polymerization by laccase was optimized in terms of pH, temperature and initial dopamine concentration. It was demonstrated that the highest enzymatic polymerization of dopamine was achieved at pH 5.5, 30°C and 2 mg ml−1 of dopamine. Then, ABS composed of polymers, salts and ionic liquids were evaluated to optimize the laccase confinement in one phase while PDA is recovered in the opposite phase. The most promising ABS allowing the separation of laccase from the reaction product is composed of polypropylene glycol (400 g mol−1) and K2HPO4. The polymerization of dopamine in ABS leads to a remarkable improvement of polymerization of 3.9-fold in comparison to the conventional chemical PDA polymerization. The phase containing the confined laccase was reused for four consecutive reaction cycles, with a relative polymerization of 68.9% in the last cycle. The results of this work proved that ABS are a promising approach to create a liquid support for enzyme reuse allowing the process intensification efforts. The use of biocatalysts in ABS emerges as sustainable and alternative platforms from environmental and techno-economic points of view.
A cell adhesion-promoting multi-network 3D printing bio-ink based on natural polysaccharide hydrogel
Authors: Qi Yong , Zhang Shuyun , He Yanni , Ou Shuanji , Yang Yang , Qu Yudun , Li Jiaxuan , Lian Wanmin , Li Guitao , Tian Junzhang , Xu Changpeng
Published: November 2022

Due to its high biosafety, gellan gum (GG) hydrogel, a naturally occurring polysaccharide released by microorganisms, is frequently utilized in food and pharmaceuticals. In recent years, like GG, natural polysaccharide-based hydrogels have become increasingly popular in 3D-printed biomedical engineering because of their simplicity of processing, considerable shear thinning characteristic, and minimal pH dependence. To mitigate the negative effects of the GG’s high biological inertia, poor cell adhesion, single cross-linked network, and high brittleness. Mesoporous silica nanospheres (MMSN) and Aldehyde-based methacrylated hyaluronic acid (AHAMA) were combined to sulfhydrated GG (TGG) to create a multi-network AHAMA/TGG/MMSN hydrogel in this study. For this composite hydrogel system, the multi-component offers several crosslinking networks: the double bond in AHAMA can be photocrosslinked by activating the photoinitiator, aldehyde groups on its side chain can create Schiff base bonds with MMSN, while TGG can self-curing at room temperature. The AHAMA/TGG/MMSN hydrogel, with a mass ratio of 2:6:1, exhibits good cell adhesion, high strength and elasticity, and great printability. We believe that this innovative multi-network hydrogel has potential uses in tissue regeneration and biomedical engineering.
A DFX-based iron nanochelator for cancer therapy
Authors: Liu Peng , Wang Qiang , Li Kuan , Bi Bo , Wen Ying-Fei , Qiu Miao-Juan , Zhao Jing , Li Bin-Bin , Zhang Chang-Hua , He Yu-Long
Published: November 2022

Iron as an essential element, is involved in various cellular functions and maintaining cell viability, cancer cell is more dependent on iron than normal cell due to its chief characteristic of hyper-proliferation. Despite that some of the iron chelators exhibited potent and broad antitumor activity, severe systemic toxicities have limited their clinical application. Polyaminoacids, as both drug-delivery platform and therapeutic agents, have attracted great interests owing to their different medical applications and biocompatibility. Herein, we have developed a novel iron nanochelator PL-DFX, which composed of deferasirox and hyperbranched polylysine. PL-DFX has higher cytotoxicity than DFX and this effect can be partially reversed by Fe2+ supplementation. PL-DFX also inhibited migration and invasion of cancer cells, interfere with iron metabolism, induce phase G1/S arrest and depolarize mitochondria membrane potential. Additionally, the anti-tumor potency of PL-DFX was also supported by organoids derived from clinical specimens. In this study, DFX-based iron nanochelator has provided a promising and prospective strategy for cancer therapy via iron metabolism disruption.
The government of Indonesia’s smart city development: Fiscal capacity, cognitive models in decision making, excessive caution about future accrual of benefits, and null regulatory leadership
Authors: Bastian Indra , Effendi Ruslan , Susanto Efa Agus , Unggara Ilham , Sumiyana Sumiyana
Published: November 2022

This article investigates the lack of certainty regarding the success of smart city development in the Government of Indonesia’s regions. The authors suspect that developing smart cities in each region ran independently and nationally, without a unifying strand of knowledge and information system leadership models. Based on these statuses and circumstances, this research examines these phenomena with two critical perspectives: The cognitive model of double-loop learning of smart city development and a dexterous strategy in terms of political economy. Consequently, this study finds that the regions developing a smart city act according to the statuses: Working with only fiscal budget readiness, cognitive models in the decisions to create future works, excessive caution about accruing potential future benefits, and null regulatory leadership in terms of guidelines. Thus, this study concludes that regions develop smart cities in their self-imagination without profound directional boundaries.
In vitro modeling of glucocorticoid mechanisms in stress-related mental disorders: Current challenges and future perspectives
Authors: Bassil Katherine , De Nijs Laurence , Rutten Bart P. F. , Van Den Hove Daniel L. A. , Kenis Gunter
Published: November 2022

In the last decade, in vitro models has been attracting a great deal of attention for the investigation of a number of mechanisms underlying neurological and mental disorders, including stress-related disorders, for which human brain material has rarely been available. Neuronal cultures have been extensively used to investigate the neurobiological effects of stress hormones, in particular glucocorticoids. Despite great advancements in this area, several challenges and limitations of studies attempting to model and investigate stress-related mechanisms in vitro exist. Such experiments often come along with non-standardized definitions stress paradigms in vitro, variations in cell models and cell types investigated, protocols with differing glucocorticoid concentrations and exposure times, and variability in the assessment of glucocorticoid-induced phenotypes, among others. Hence, drawing consensus conclusions from in-vitro stress studies is challenging. Addressing these limitations and aligning methodological aspects will be the first step towards an improved and standardized way of conducting in vitro studies into stress-related disorders, and is indispensable to reach the full potential of in vitro neuronal models. Here, we consider the most important challenges that need to be overcome and provide initial guidelines to achieve improved use of in vitro neuronal models for investigating mechanisms underlying the development of stress-related mental disorders.
Online driver model parameter identification using the Lyapunov approach based shared control
Authors: Oudainia Mohamed Radjeb , Sentouh Chouki , Nguyen Anh-Tu , Popieul Jean-Christophe
Published: November 2022

The work described in this paper proposes a new conflict minimisation strategy in shared driving control for lane keeping systems (LKS) in intelligent vehicles. This strategy takes into account a dynamic driver model, where the driver’s parameters are identified online using the Lyapunov approach. The design of an adaptive shared controller is based on the dynamic parameters of the driver model which changes according to the driver and the situation encountered. Based on Lyapunov stability arguments, the overall asymptotic stability of the closed-loop control system with the adaptive driver model and the variation of the vehicle speed is proved and an LMI optimization is used to formulate the control design. The simulation results, conducted with the SHERPA dynamic car simulator under real-world driving situations, show the importance of integrating a dynamic driver model in the controller design in order to decrease the conflict between the driver and the lane keeping system and to ensure the safety of the vehicle as well as to increase the confidence and acceptability of the driver.
Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood
Authors: Konrath Sandra , Mailer Reiner K. , Beerens Manu , Englert Hanna , Frye Maike , Kuta Piotr , Preston Roger J. S. , Maas Coen , Butler Lynn M. , Roest Mark , de Laat Bas , Renné Thomas
Published: November 2022

Calibrated Automated Thrombography (CAT) is a versatile and sensitive method for analyzing coagulation reactions culminating in thrombin generation (TG). Here, we present a CAT method for analyzing TG in murine whole blood by adapting the CAT assay used for measuring TG in human plasma. The diagnostically used artificial and physiologic factor XII (FXII) contact activators kaolin, ellagic acid and polyphosphate (polyP) stimulated TG in murine blood in a dose-dependent manner resulting in a gradual increase in endogenous thrombin potential and peak thrombin, with shortened lag times and times to peak. The activated FXII inhibitor rHA-Infestin-4 and direct oral anticoagulants (DOACs) interfered with TG triggered by kaolin, ellagic acid and polyP and TG was completely attenuated in blood of FXII- (F12−/−) and FXI-deficient (F11−/−) mice. Moreover, reconstitution of blood from F12−/− mice with human FXII restored impaired contact-stimulated TG. HEK293 cell-purified polyP also initiated FXII-driven TG in mouse whole blood and addition of the selective inhibitor PPX_Δ12 ablated natural polyP-stimulated TG. In conclusion, the data provide a method for analysis of contact activation-mediated TG in murine whole blood. As the FXII-driven intrinsic pathway of coagulation has emerged as novel target for antithrombotic agents that are validated in mouse thrombosis and bleeding models, our novel assay could expedite therapeutic drug development.
Exciting opportunities in planetary structural geology and tectonics: An early career perspective
Authors: Crane Kelsey , Galluzzi Valentina
Published: November 2022

The outer shells of solid planetary bodies have been all subject to deformation during their history. The nature and style of deformation strictly depends on the evolution of each planetary body. Earth’s lithospheric style of deformation is related to plate tectonics, but it turns out to be a unique case in our Solar System. How can we study the tectonics of other planetary bodies? How and why do planetary lithospheres deform, and what are the implications of these processes? These are the driving questions for investigations of modern planetary structural geology. The improvement in technology, machine learning analyses, and quality and quantity of planetary space mission data give us the chance to deepen our grasp in planetary surface deformation. The lack of micro-to-local scale information that is so crucial in Earth structural geology studies has driven planetary structural geology to advance pioneering methods to study crustal deformation. Conversely, the study of old deformed surfaces such as those of Mercury, the Moon and Mars will deepen our grasp on the early evolution of Earth tectonics.
Variable seismic responsiveness to stress perturbations along the shallow section of subduction zones: The role of different slip modes and implications for the stability of fault segments
Authors: Zaccagnino Davide , Telesca Luciano , Doglioni Carlo
Published: November 2022

Assessing the stability state of fault interfaces is a task of primary interest not only for seismic hazards, but also for understanding how the earthquake machine works. Nowadays it is well known that a relationship exists between slow and fast earthquakes; moreover, it is more and more evident that such a connection is quite diffuse all over the Earth. In this paper, we perform a spatial and temporal analysis of both geodetic and seismic—non-volcanic tremors, low-frequency events (LFEs), and regular earthquakes—time series. We focus on the relationship between the clustering of properties of the different kinds of seismicity and their response to stress perturbations. Earth tides and large earthquakes are used as a source of additional stress. Seismic activity hosted in the Cascadia subduction zone, Manawatu region in New Zealand, and Japan during the last two decades is considered. Our analysis suggests that tremors become more and more sensitive to Earth-tide perturbations as the fault interface is seismically locked. Therefore, tremors and regular events show a similar response to tidal stress perturbations. This feature is also accompanied by relatively lower spatial and temporal coefficients of variation. A series of recordings by several GNSS stations along the Hikurangi Trench, North Island, New Zealand, and along the Nankai coasts in Japan is taken into account for studying how large thrust-faulting earthquakes affect silent events and geodetic signals and vice versa. In the last section, a simple model for grasping a glimpse of the local stability condition of the Earth’s crust and for explaining previous observations is provided.
Why are certain items more difficult than others in a competency test for music–related argumentation?
Authors: Ehninger Julia , Knigge Jens , Rolle Christian
Published: November 2022

This paper examines why certain items in a competency test for music-related argumentation are more difficult than others. Based on previous studies on school-related achievement tests, the authors assume that differences in item difficulty are related to different item characteristics or combinations of characteristics. In this study, the item characteristics of a test for music-related argumentation were first identified and coded. Three domains were identified as contributing to item difficulty: cognitive requirements, knowledge, and formal item features. Second, multiple linear regression analyses were conducted with the item characteristics as predictors of item difficulty, which had been estimated in a prior study. A comparison of three regression models confirmed that the model holding four predictors of the domain “cognitive requirements” best fit the study dataRadj2=0.71. The strongest predictor in the final model was “reference to musical attributes” β=0.46,β=0.51, followed by “cross-sentence argumentation” β=0.37 and “dialogical argumentation” β=0.20. These results indicate that the difficulty of an item increased most when participants had to refer to musical attributes to solve the task. The items that required the participants to provide cross-sentence or dialogical argumentation were more challenging as well. The findings regarding the relations between item characteristics and item difficulty contribute to a better understanding of music-related argumentative competence, with important implications for the music classroom.