bluuebunny/crossref_metadata_2025 huggingface dataset:
Combatant Immunity for Members of the Nagorno-Karabakh Army: A Case Study
Authors: Сушков Сергей Павлович , Неверова Евгения Владимировна
Published: August 2024

After Azerbaijan regained control over the territory of the Nagorno-Karabakh region, it detained a number of officials of the Nagorno-Karabakh Republic (hereinafter — NKR) and members of the Nagorno-Karabakh Defence Army (hereinafter — NKDA). The detainees face charges of participating in illegal armed formations and/or terrorism financing. The present case study explores whether the detainees might benefit from combatant immunity and whether Azerbaijan’s prosecution of those who fought for the NKR complies with international humanitarian law. Referencing the rules on prisoner of war status specified in Article 4(2) of the Third Geneva Convention, this paper concludes that members of the NKDA indeed fell into the hands of the “enemy”, NKDA prima facie complied with the “four requirements” for irregular armed formations per Article 4(2) and “belonged” to Armenia, that for these purposes can be deemed to have been engaged in an international armed conflict with Azerbaijan. If evidence available to the Azerbaijani authorities supports the view that NKDA members fit the requirements of Article 4(2) of the Third Geneva Convention, members of the NKDA should be treated as prisoners of war and lawful combatants. Therefore, being a member of the NKDA or supporting its activities should not be criminally punishable.
Дорога к утопии вымощена противоречиями: теоретическое осмысление принципа равенства
Authors: Сечин Даниил Сергеевич
Published: August 2024

Идея суверенного равенства является основой функционирования современного международного права и аргументации в дискуссиях о нарушении права и его эффективности. Она отражена в основных правовых актах, однако на деле, прикрываясь ширмой равенства, сильные государства воздействуют на слабые, навязывая им свою волю. Методология исследования основана на изучении номоса равенства, то есть упорядоченности норм, существующей в правовом воображении. Номос формируется через различные контексты и институциональные структуры. Поместив номос в историческую ретроспективу, можно увидеть, как он менялся и откуда взял свое начало. Истоки идеи равенства восходят к языческим сообществам, где сформировались два глобальных видения порядка: плюралистичный космос и иерархичная вселенная. Христианские нарративы провозглашали всеобщее равенство и единение, но при этом они переняли видение порядка вселенной, которая выстраивала иерархию, исключающую «не таких». Постепенно произошло изменение парадигмального взгляда, и разум стал основой познания. С разумом пришла идея прогресса и цивилизации. Цивилизованность обещала наступление равенства, ведь люди с помощью разума могли достичь благ европейского мира и сравниться с ним. Однако она также несла в себе неравенство и дискриминацию. Но в ХХ веке глобальный нарратив, описывающий все право, стал исчезать из юридической дискуссии. Одновременно с этим появилось множество новых нарративов, деконструирующих идею глобального порядка. В итоге номос равенства наполнен противоречиями и используется лишь как инструмент влияния, так как неравенство и дискриминация существуют в нем в силу восприятия порядка как вселенной. В результате концепция суверенного равенства оказывается противоречивой и бессодержательной. Вызванный этим кризис науки и права разрешается изменением культуры и отрицанием порядка вселенной. Метамодернистское видение мира предполагает возможность переустройства правопорядка на основе космоса и возникновения гомогенных плюралистичных режимов, каждый из которых построен на собственной системе ценностей. Российский проект равенства может опираться на идеи религиозной философии и концепции всеединства В. С. Соловьева, основанной на любви. Такой отдаленный проект утопии наполняет бессодержательное понятие равенства определенными ценностями и идеями.
Reversible Lesion in the Splenium of the Corpus Callosum due to Thermogenic Dietary Supplements
Authors: Jung Heuiseop , Lee Kyungwon , Hwang Iljung , Kim Jungwoo , Kim Jisoo , Lee Jung Hwan
Published: August 2024

The use of thermogenic dietary supplements has led to growing concerns about potential adverse health effects. A 19-year-old female patient experienced recurrent blurred vision after consuming thermogenic dietary supplements for 5 weeks and eating only one meal per day. Initial brain imaging showed a lesion at the corpus callosum, which disappeared after a month, and her symptoms resolved within 2 days. The potential risks associated with using thermogenic dietary supplements in combination with intermittent fasting need to be carefully considered.
Cryo-electron microscopy and helical reconstructions of α-synuclein fibrils v1
Authors: Sokratian Arpine , Bhattacharya Nilakshee , Viverette Elizabeth
Published: August 2024

This protocol describes how to create cryo-EM grids for α-synuclein fibril image collection. It also includes the specific settings for the KRIOS microscope, including parameters for latitude collection and contains details on post-image collection processing for model generation.
Amme İdaresi Dergisi’nin Bibliyometrik Analizi (2007-2023)
Authors: Payam Mehmet Murat
Published: August 2024

Amme İdaresi Dergisi’nin (AİD) bibliyometrik analiz ile incelendiği bu çalışmada, AİD’de 2007 yılından 2023 yılına kadar yayımlanan 401 makale ve 578 yazara ilişkin veriler kullanılmıştır. Çalışmada önce, AİD’e ait genel bulgular ortaya konulup yorumlanmıştır. Sonra makale yazarları; yazar sayısı, cinsiyeti, akademik unvanları, yazar üretkenliği, kurumları ve kurum türleri, Fakülte/Enstitü ve anabilim dalı; makaleler ise, konu, anahtar kelimeler, yıl, dil ve makale kabul süresi gibi ölçütler temel alınarak değerlendirilmiştir. Çalışmada, AİD’de makalelerin en çok tek yazarlı olduğu, erkek araştırmacıların katkı düzeyinin daha yüksek olduğu, doktor öğretim üyesi unvanlı yazarların en çok katkıda bulunduğu, en üretken yazarın dört makale ile katkıda bulunduğu, katkı sunan 142 farklı kurumun büyük çoğunluğunu devlet üniversitelerinin oluşturduğu, ‘kamu yönetimi’, ‘devlet yönetimi’ gibi ana konu başlıklarına daha çok odaklanıldığı, her yıl farklı sayıda makale yayımlandığı, makalelerin neredeyse hepsinin Türkçe yazıldığı ve makale değerlendirme süresinin ortalama 185 gün olduğu gibi bulgulara ulaşılmıştır. Elde edilen bulgular, ayrıntılı biçimde analiz edilmiş ve önceki araştırmalar ile karşılaştırılarak sunulmuştur. Bu çalışma ile elde edilen sonuçlar, AİD’in yayımlandığı ilgili yıllar arasında bibliyometrik olarak genel tabloyu özetlemesi ve 2024 ve sonrası AİD’in yayın hayatına ışık tutması açısından önem taşımaktadır.
From Board Games to Video Games and the World of Avatars: Jumanji: Welcome to the Jungle
Authors: Doğan Melike , Bakşi Yalçın Olgahan
Published: August 2024

In the digital age, the relationship between film and literature demonstrates how different forms of art can collaborate to improve the storytelling experience. Rather than competing, these mediums complement one another, each bringing their own strengths to the storytelling process. This mutual relationship not only enhances the audience's experience but also fosters a greater appreciation for both film and literature (Hutcheon, 2006; Sanders, 2016). The various film adaptations of Chris Van Allsburg’s picturebook Jumanji (1981) are excellent examples of how literature and film can complement and improve one another over time. The first major adaptation of Jumanji was released in 1995 starring Robin Williams and directed by Joe Johnston. Decades later, the story of Jumanji was revitalized with the releases of Jumanji: Welcome to the Jungle (2017) and Jumanji: The Next Level (2019) both directed by Jake Kasdan. These adaptations illustrate the changing nature of storytelling across mediums and how each new iteration introduces new perspectives and engages contemporary audiences in novel ways. Mikhail Bakhtin’s concepts of heteroglossia and dialogic relationship (1981) are great tools for understanding how different voices and cultural contexts interact within and between texts, thereby revealing the dynamic nature of storytelling and interpretation. Thus, this paper aims to investigate how Bakhtin's concepts of heteroglossia and dialogic relationship function in Jake Kasdan's 2017 sequel, focusing on how the film adaptation evolves in response to its contemporary context.
Atenção à saúde no processo de parturição de mulheres imigrantes: uma revisão de escopo
Authors: Santos Isabella Zerbeto dos , Trigueiro Tatiane Herreira , Oliveira Abio André Miranda de , Souza Silvana Regina Rossi Kissula , Hornung Helena
Published: August 2024

Objetivo: identificar o que se tem publicado no Brasil sobre mulheres imigrantes em processo de parturição. Método: revisão de escopo estruturada, conforme o fluxograma PRISMA- ScRe seguindo as etapas do método propostas pelo Joanna Briggs Institute. Incluíram-se publicações em inglês, espanhol e portuguê sentre 2011 e 2023 e que abordassem o tema processo de parturição de mulheres imigrantes no Brasil.A busca foi realizada em quatro bases de dados e na literatura cinzenta. Resultados: sete artigos foram incluídos e foram observadas que as dificuldades existentes durante a assistência ao parto de imigrantes no Brasil envolvem barreiras de comunicação e dificuldades de manifestação cultural das mulheres. Estratégias como intérpretes, elaboração de materiais e capacitação dos profissionais foram identificadas. Conclusão: estratégias precisam ser levantadas e efetivadas pelas instituições e profissionais de saúde para melhoria do atendimento.
The Bumpy Road to Becoming a Data-Driven Enterprise
Authors:   The University of Auckland, Kotlarsky Julia , Oshri Ilan ,   The University of Auckland, Sarker Suprateek ,   University of Virginia
Published: August 2024

Nowadays organizations are often inspired to become data-driven enterprises that continuously and systematically use data (from internal and external sources) to inform strategic decision-making and actions to improve operational efficiencies, products, services, customer experience, and competitiveness. Such use of data implies that organizational actors across different organizational functions are making decisions based on information derived from analytical insights. Yet, many companies find the journey to becoming a data-driven enterprise a bumpy ride. A key issue faced by most firms is that their data management approach is not ready for data and analytics-based decision-making. In this teaching case, we follow the journey of an industrial enterprise, PETRONAS, attempting to transform into a data-driven enterprise. We report on four key data-driven ‘blockers’ encountered by PETRONAS Downstream and provide insights into steps taken to address these data challenges. This case study is suitable for courses that explore digital transformation and data management in an organizational context, from strategic and operational perspectives. For example, instructors teaching a Digital Transformation course might use this case for a session dedicated to learning about data-readiness for digital transformation. It is intended for postgraduate students (Master and MBA levels) as well as late-stage undergraduate students. Specific angles that could be explored in depth are: identifying and capturing data-related requirements and issues from the perspectives of different organizational actors; examining interdependencies between functional and technical aspects of data management and use (e.g., requirements, availability, sustainability of data supply) for fast and reliable decision-making; sourcing of data: evaluating in-house and outsourced approaches for data sourcing and management; implementation of data-related projects and change management.
Artificial intelligence in healthcare and medicine: the history of key events, its significance for doctors, the level of development in different countries
Authors: Lamotkin A. I. , Korabelnikov D. I. , Lamotkin I. A. , Livshitz S. A. , Perevalova E. G.
Published: August 2024

The article is devoted to analysis of the stages of development and current directions of research and practical application of artificial intelligence (AI) in the field of healthcare and medicine based on scientific publications in PubMed/MEDLINE, Scopus, Web of Science, Embase, eLibrary and CyberLeninka. The dynamics of scientific publications on AI in healthcare and medicine is shown, and an analysis of the growth of investments in software development based on AI in recent years is provided. AI can achieve comparable accuracy in the diagnosis of diseases in comparison with human decisions. However, future research should focus on comparing the clinical results of diagnosis and treatment performed by doctors who make decisions based on AI with the results of clinical work by doctors who do not use AI. The importance of training specialists able to combine knowledge in the field of medicine with the skills of using AI is emphasized.
Cost-effectiveness analysis of acalabrutinib in treatment of patients with relapsed/refractory form of mantle cell lymphoma who previously received at least one line of therapy
Authors: Zyryanov S. K. , Dyakov I. N.
Published: August 2024

Objective: to conduct a clinical and economic study of acalabrutinib for the treatment of adult patients with relapsed/refractory form of mantle cell lymphoma who previously received at least one line of therapy in the Russian Federation.

Material and methods. Acalabrutinib and ibrutinib were considered as compared treatment options. Based on the adjusted indirect comparison, they were found to be comparable in terms of overall survival and progression-free survival. Therefore, a cost minimization analysis method was selected for the study. Based on results of ACE-LY-004 clinical trial a distributed survival model was developed. The model was used to calculate drug costs over a 3-year horizon. To explore uncertainty in the results of economic evaluations we conducted a sensitivity analysis. A number of patients in the hypothetical cohort who could be further treated with a less expensive drug was determined during a missed opportunity analysis. Both mean life years gained and mean progression-free life years were calculated too.

Results. Based on simulations over a 3-year horizon, the mean life years gained were 2.45, and the mean progression-free life years were 1.75. The average costs of acalabrutinib therapy both over 1 year and in total over 3 years were 36.6% lower compared to ibrutinib. So, in the 1st year, the costs for acalabrutinib were 3,546,237,60 rubles, for ibrutinib – 5,591,391,00 rubles (a difference of 2,045,153,40 rubles). Using acalabrutinib for 3 years was associated with costs of 7,252,980,60 rubles compared to 11,435,852,60 rubles for ibrutinib (a decrease of 4,182,872,00 rubles). Univariate multi-way sensitivity analysis showed the robustness of modeling results to price fluctuations in the range ±10%. For a hypothetical cohort of 100 patients, using acalabrutinib instead of the more expensive ibrutinib within the same budget will provide therapy to additional 57 patients per year.

Conclusion. The results of the study demonstrated that acalabrutinib compared to ibrutinib for the treatment of adult patients with relapsed/ refractory form of mantle cell lymphoma can reduce costs for the 1st year of therapy by 2,045,153,40 rubles (36.6%), and by 4,182,872,00 rubles (36.6%) for 3 years. Thus, acalabrutinib is the cost-saving option for previously treated adult patients with relapsed/refractory mantle cell lymphoma in the Russian Federation.
Regulatory Legal Acts Pertaining to the Transplantation and Manufacture of Medical Devices from Human Organs and Tissues
Authors: Volova L. T. , Maksimenko N. A. , Levina M. V.
Published: August 2024

The need to include specialized norms of modern Russian law in legislation governing the manufacture of medical devices from human biological material is considered on the example of normative legal acts regulating relations. A retrospective analysis of the development of legal regulation in the field of the use of human biomaterial in medicine, reveals the origins of the discussed issue. Current legislation in the Russian Federation in the field of organ and tissue donation for the purposes of transplantation and the use of human biological material for the production of medical devices is examined taking a specialized legal approach. A current lack of legal regulation in this area is revealed. While some issues associated with the use of human biomaterial for the manufacture of medical devices are fixed at the level of by-laws, the production of medical devices and biofabricated products is hindered by a lack of legal regulation in these areas of contemporary medicine. Required improvements in the legal foundations of regenerative and reconstructive medicine in the Russian Federation will involve the development of an independent federal law that includes norms and definitions for delimiting the provisions of regenerative and reconstructive medicine in related fields of medicine. As well as distinguishing between basic concepts in the fields of replacement-, regenerative- and reconstructive medicine, the definitions of these concepts must be consolidated in normative legal acts. Proposed definitions related to medical technologies and the use of human biomaterial are presented in the form of a new terminological glossary of innovative technologies involving the use of human biological material.
Étude de l’usage de l’épigraphe dans Le bec de canard, de Gilbert Sinoué
Authors: Dirhoussi Loubna
Published: August 2024

Cet article s’assigne comme objectif d’étudier la pratique épigraphique dans Le bec de canard de Gilbert Sinoué et d’en analyser les enjeux esthétiques. Pour ce faire, cette contribution part de l’hypothèse que ladite pratique relève de l’esthétique de l’hétérogène qui imprime au texte une dynamique intérieure et y installe une intertextualité soucieuse de la richesse et de la variété des imaginaires culturels et littéraires. Cette pratique est aussi le signe d’une altérité textuelle et littéraire recherchée par l’auteur. Le roman de Sinoué précité s’avère être le lieu de rencontre de plusieurs textes, d’obédiences différentes. Ainsi cette contribution s’articulera-t-elle autour de deux axes : dans un premier lieu, nous fournirons quelques considérations théoriques sur l’intertextualité ; dans un second lieu, nous analyserons la pratique de l’épigraphe dans l’œuvre susmentionnée.
Aldeia mais Portuguesa de Portugal e tropeiros em Diamantina
Authors: Romano Luís Antônio Contatori
Published: August 2024

Neste estudo são analisados um artigo de Adolfo Simões Müller, publicado na revista Panorama, em 1941, editada pelo SPN, e outro de Basílio de Magalhães, publicado na revista Travel in Brazil, em 1942, editada pelo DIP. Ambos abordam aspectos da cultura popular rural e são ilustrados com fotografias de Thomaz de Mello e de Erich Hess, respectivamente. Müller trata da aldeia de Monsanto e Magalhães, de tropeiros no Mercado Municipal de Diamantina. Objetiva-se compreender como esses autores e fotógrafos representam diferentes concepções de cultura popular rural. Para o Estado Novo português, esta era concebida como imutável, mas devia ser estilizada, preparada para o olhar turístico e tomada como modelo para as classes urbanas. Para o regime homônimo brasileiro, devia ser registrada, cultuada como gênese da identidade nacional, mas era percebida como em vias de superação devido à política desenvolvimentista de Vargas.
recepção de Horácio em Ricardo Reis
Authors: Trevizam Matheus , Paiva Gabriella Cristine Ferreira
Published: August 2024

O objetivo deste artigo é examinar, com base em exemplos concretos de temas poéticos, tópoi e adesão ao epicurismo, como se deu a recepção da obra do poeta latino Quinto Horácio Flaco em Ricardo Reis (heterônimo de Fernando Pessoa). Os resultados apontam, de acordo com os procedimentos comparativos dos “estudos da recepção”, que o poeta português estabeleceu diálogo crítico com seu modelo antigo. Ou seja, na obra atribuída a Ricardo Reis, os elementos de matriz Clássica foram recebidos criativa e criticamente, mais do que com passividade. Por fim, concluímos o estudo reforçando que se encontram confluências entre pressupostos básicos da teoria citada e as Odes de Pessoa.
Águas pós-coloniais em romances angolanos e moçambicanos
Authors: Falconi Jessica
Published: August 2024

Este artigo apresenta uma proposta de cartografia do papel narrativo da água na literatura angolana e moçambicana, através da leitura comparada de quatro romances: O desejo de Kianda (1995) do angolano Pepetela; O livro dos rios (2006) de Luandino Vieira; Água: uma novela rural (2016) e Ponta Gea (2017) ambas do moçambicano João Paulo Borges Coelho. A introdução situa a cartografia proposta no quadro dos estudos de ecocrítica, cujos vários paradigmas oferecem ferramentas e conceitos úteis para a leitura das obras literárias selecionadas. A abordagem metodológica temática e comparativa evidencia experiências e imaginários comuns a dois contextos pós-coloniais, apesar da diferença de cenários, temáticas, escolhas estéticas e estratégias narrativas. Os resultados da análise demonstram que a água é um elemento crucial para narrar as sociedades angolana e moçambicana pós-coloniais.
De Guerreros y Enamorados
Authors: Taiano Leonor
Published: August 2024

Este artículo analiza El Abencerraje y la hermosa Jarifa. El estudio parte de la premisa de que esta obra aboga por la tolerancia entre cristianos y musulmanes en la frontera del Al-Ándalus. La amistad que surge entre Abindarráez y Rodrigo permite reinterpretar los conflictos fronterizos. Es por ello que el artículo escudriña la manera cómo en el texto se representan los motivos de la paz y la guerra. Conjuntamente, se estudia el papel de las relaciones sentimentales y la función que el amor tiene en la evolución de los protagonistas. Mi ensayo parte de la hipótesis de que la amistad que surge entre Abindarráez y Rodrigo permite reinterpretar los conflictos fronterizos y propone un mensaje ético de respeto y comprensión, cuya finalidad consiste en educar al lector sobre las naturales tendencias a la solidaridad en el ser humano.
TRANSCUTANEOUS LASER IRRADIATION OF BLOOD IN SIMULTANEOUS MODE (S-ILIB) FOR FATIGUE RECOVERY
Authors: Soares Luís Eduardo Silva
Published: August 2024

The modified transcutaneous laser irradiation on blood (ILIB), a systemic modality of photobiomodulation therapy (PBMT), consists of a laser application on the radial artery or other artery in the body, to improve systemic functions and physiological dynamics of the body. The available therapeutic strategies for the management of fatigue due to daily life stress are mainly focused on lifestyle changes associated with nutrition and exercise. Thus, the present study aims to report a series of cases in which transcutaneous modified ILIB therapy in simultaneous mode (S-ILIB), was used to treat fatigue symptoms. Four healthy patients, without any type of significant comorbidity, reported fatigue related to stress. They were treated by the new PBMT protocol with the modified ILIB technique. The intensity or perception of fatigue was rated using a visual analogue scale (VAS). The "simultaneous technique" used in the present study consisted of laser irradiation in four sites of the body: 1- the radial artery region of the right arm; 2- the radial artery region of the left arm; 3- the right dorsal pedis artery; and 4- the left dorsal pedis artery. For PBMT, two laser device were used at 660 nm, on contact mode, with 100 mW of power. The patients reported a clear recovery in the energy sensation after the S-ILIB session. The PBMT protocol seems to be a promising therapy for managing energy recovery in fatigue-stress-related daily routines; however, complementary studies are required to establish the safest and most efficient protocol
Utility of Point-of-Care Diagnosis of Chronic Heart Failure Using an Express Test for Semi-Quantitative Determination of NT-proBNP Levels
Authors: Iosifov A. V. , Shtegman O. A.
Published: August 2024

Aim. To evaluate the accuracy of a rapid test for semi-quantitative determination of NT-proBNP levels in the diagnosis of CHF in comparison with quantitative assessment; to study the strength of the association of the results of this NT-proBNP test with indicators of the CHF severity.Material and methods. The concentration of NT-proBNP was determined in 44 patients at bedside both semi-quantitatively using an express test (BioTest, Novosibirsk) and quantitatively in a laboratory. In 11 patients, the severity of CHF was assessed with the CHF Clinical Status Scale (CSS). Echocardiography was performed in all patients.Results. The sensitivity of the quantitative and semi-quantitative tests coincided and was 95%. The specificity of the quantitative test was 100% in our study, whereas the semi-quantitative test showed a specificity of 92%. The negative predictive value of either test was 96%. The diagnostic accuracy was 98% and 93%, respectively. In patients with significantly high NT-proBNP concentrations, the semi-quantitative test demonstrated a reduced ability to verify values above 1800 pg/ml; in patients with threshold concentrations, the semi-quantitative test showed an increased subthreshold sensitivity. Increases in the NT-proBNP concentration correlated with the severity of CHF according to the stage of the disease.Conclusion. Due to the sufficiently high sensitivity, specificity, ease of use, and speed of obtaining results, the rapid test for semi-quantitative measuring NT-proBNP is promising for outpatient screening bedside diagnosis of CHF and in the emergency room to confirm or exclude CHF. When determining the dynamics of NT-proBNP during the treatment of CHF, the use of the semi-quantitative rapid test with visual assessment of the results may produce an error compared to the quantitative assessment, which will probably not allow tracking the effect of therapy or predicting exacerbation of the disease.
Green Marketing and Purchase Intention for Fore Coffee Products
Authors: Ismail Taufiq , Aldiansyah Mohammad Wildan
Published: August 2024

Green marketing for coffee products is explored for its role on purchase intention. As concern on environmental matters is raising, green marketing becomes an important part to drive customers purchase intention, more over it is in the trending business in Indonesia like coffee product. This is an explanatory research with quantitative approach that used dichotomous data and logistic regression to measure and analyze Guttman’s scale. The data used in this study are primary data obtained through questionnaires distributed directly to coffee drink consumers in Malang Raya, involving 216 respondents. The results show that green marketing simultaneously affects the purchase intention of Fore coffee drinks by 24.5%. All three variables are significant in encouraging purchase intention including green product, green promotion, and green place. Yet, green price as assumed to be more expensive is required to remain affordable. The implications of these findings are expected to deliver theoretical contribution on green marketing as price remains sensitive for customers; in addition, it also provides practical contribution on how a green company should address this issue.
PEMILIHAN HARI BAIK PERKAWINAN MASYARAKAT AENG PANAS SEBAGAI UPAYA PENCEGAHAN PERCERAIAN PERSPEKTIF MAQASHID AL-SYARI’AH
Authors: Ahmad Hafidz
Published: August 2024

This article explains a Javanese tradition, namely in the form of choosing a good day for marriage that occurs in Aeng Panas Village, Pragaan, Sumenep, in this case the people of Aeng Panas Village think that for couples who are going to get married they must look for a good day, because the selection of a good day in marriage according to the calculation has a positive impact and a negative impact, Positive impacts can launch and bring happiness to the bride and groom, the negative impact can bring bad luck and bad luck. Meanwhile, in the view of the Islamic context, it is not explained that there is an unlucky day or a bad luck bearer. This study uses a qualitative research approach using ethnography, which is research that describes a culture from a group of people, the culture in question is to understand and study the life of the individual studied through maqashid al-syariah. Based on research, it was found that the people of Aeng Village are hot when they are going to carry out a wedding first, they will go to their teacher or elders in the village who understand in terms of choosing a good day for the bride and groom. The background for choosing a good day is as a medium (washilah) for the safety of one's household, as well as maintaining traditions that have been passed down from generation to generation from ancestors. From the perspective of maqashid sharia, choosing a good day as one of the marriage rites is included in the category of al-maslahat tahsiniyyat (tertiary). The tradition contains positive values, namely for the safety of his household and to avoid divorce.
Evaluación de la eficiencia productiva en las instituciones prestadores de servicios de salud de Caldas
Authors: Hincapié Mesa Fabio Andrés , Montoya Morales Alexa Juliana
Published: August 2024

Las instituciones prestadoras de servicios de salud a nivel mundial se han enfrentado a un desafiante escenario debido a la pandemia por covid-19. Esta situación ha suscitado el interés por estudiar la eficiencia y productividad que permita la mejora en la toma de decisiones y aumenta la capacidad de respuesta de los hospitales, optimizando los recursos con los que cuenta cada institución para atender adecuadamente a sus pacientes, a pesar de que estos recursos generalmente son escasos. Para lograrlo, se utilizó el análisis envolvente de datos y el índice de Malmquist, a fin de evaluar el desempeño de catorce instituciones hospitalarias de Caldas que disponen de camas UCI, entre los años 2020 y 2021. Dentro de los principales hallazgos durante el periodo de análisis se encuentra el mejoramiento de desempeño de los hospitales en un 4,6 %, aunque se evidencian algunas instituciones que se alejaron de la frontera. Además, se realizó un análisis descriptivo que determinó un aumento en el número de casos de pacientes recuperados, así como de aquellos que requirieron hospitalización. No obstante, se estableció una disminución de los pacientes que necesitaron el servicio de cama uci y del total de fallecimientos. Se determinó que la mayoría de pacientes fallecidos tenían comorbilidades y preexistencia médica.
Digital Therapeutics: Catalyzing Personalized Medicine and the Pursuit of Equitable Healthcare
Authors: Choudhary Chetan
Published: August 2024

The Article Abstract is not available.
Assessment of Knowledge and Practice Regarding Disposal of Unused and Expired Drugs in Medical Professionals in a Tertiary Care Teaching Hospital in Eastern India: A Cross- Sectional, Questionnaire-based Study
Authors: Gangopadhyay Tanmoy , Chakraborty Arup , Kumar Subir , Banerjee Shritama , Khatua Dilip
Published: August 2024

Background: Despite the effect of drugs on human body getting wide attention worldwide the effect of disposed drugs on the environment is largely neglected.  Since the doctors  working in a teaching hospital are the major stakeholder in ensuring proper  and safe disposal of drugs their knowledge, attitude and practice regarding drug disposal was assessed in this study.Methods: A pre-validated questionnaire was given to the doctors working in a tertiary care teaching  hospital through Google form from 1st June,2023 to 31st July 2023. Their responses were recorded in a Microsoft excel form and analyzed.
Results: It was observed that while buying medicines 87.5% of physicians check the date of expiry but only 78.9% do that while receiving physician’s sample from the medical representatives. Among the participants in this study 97.2% declared that medicines remain unused in their homes. In case of unused drugs, 45.8% donate them to patients or hospitals, and 29.2% throw them away with household garbage whereas in case of expired medicines majority (56.9%) throw them away. Among the participants 38.9% had never instructed their patients about the proper disposal methods.
Conclusion: To ensure proper drug disposal programs should be initiated to increase awareness about the danger of improper drug disposal not only in general population but in medical community also.
Challenges of the Intellectual Property System in Pharmaceutical Innovations Resulting from Artificial Intelligence
Authors: Sabet Babak , Eslamitabar Shahriar , Lame Ehsan , Anvar Fatemeh
Published: August 2024

The patent system has long been criticized for limiting access to medicines. Dramatic advances in artificial intelligence and machine learning technology present a revolutionary opportunity in drug discovery, formulation and testing of dosage forms. The pharmaceutical industry claims that patenting is necessary to encourage innovation in the risky, lengthy, and costly research and development (R&D) process. But it still does not provide logical evidence about the actual effects of patents on innovation. The increasing use of artificial intelligence in research is intensifying the debate about pharmaceutical patents. Inventions created or enabled by artificial intelligence raise questions about patentability and patent policy in general. Faster and more efficient research and development weakens the justification for pharmaceutical patents. Research findings suggest that despite the necessity of continuing incentives for drug research and development, lawmakers should consider alternative systems that prioritize access alongside incentives to advance healthcare as a human right.
Self-Medication “Boon or Bane!!”: A Cross-Sectional Survey of Undergraduate Medical Students
Authors: Mukadam Fehmi M. , Gawali Ujwala P.
Published: August 2024

Background: Self-medication can be a boon as well as curse to mankind whose proper application can reduce the unnecessary pressure on the health care system. The focus of this study was to assess the knowledge, attitude, and self-medication practices among undergraduate (UG) medical students, who are more likely to self-medicate themselves due to their limited knowledge and easy drug availability.
Methods: The study involved distributing questionnaires among undergraduate medical students at Government Medical College, using a cross-sectional approach. The data was collected in June 2022, with 360 responses analyzed. The questionnaire, consisting of 17 close-ended questions, included demographics, prevalence, indications for self-medication, commonly self-medicated drugs, patterns of self-medication, and knowledge about safety and consequences.
Results: 327 students willingly participated in the study of which 164 were females and 163 were males belonging to the age group of 18-25 years. The prevalence of self-medication was found to be 75.5%. Most common indication was cold, cough & sore throat (70.4%) followed by headache (66%). Antipyretics (71.2%) and analgesics (62.3%) were most commonly used class of drugs. 84.5% students are aware about adverse effects of drugs. 74% opine that self-medication is not a good practice.
Conclusion: Due to rising incidence of self-medication amongst the undergraduate medical students there is an increased risk of adverse drug effects. Thus, it is crucial to undertake measures that emphasize education and awareness, aiming to discourage self-medication among them.
The impact of negative pressure wound therapy on surgical site infection rates in obese women following cesarean section: A systematic review and meta‐analysis
Authors: Arian Mahdieh , Kamali Azadeh
Published: August 2024

Background & Aim: This study aims to assess the surgical site infection (SSI) rate in obese women undergoing C-sections, comparing negative pressure wound therapy (NPWT) and standard dressings.
Methods & Materials: In this systematic review and meta-analysis, databases including Science Direct, Medline/PubMed, Web of Science, Scopus, and Cochrane Library were searched for articles published up to January 2024. The selection criteria included randomized controlled trials and cohort studies comparing the effect of (NPWT) with standard dressings on wound complications in women with obesity undergoing C-sections. Data collection and analysis Pooled effect sizes were calculated using random effects models based on heterogeneity.
Results: Out of 20 included studies, 18 reported SSI rates, which included 9243 cases and showed that NPWT reduces the rate of SSIs in obese women undergoing C-section (RR: 0.8, 95% CI: 0.66–0.96, I2= 24.5%, P= 0.01). An in-depth examination of 13 high-quality studies, in which NPWT devices were used, reveals a pooled Mantel-Haenszel (M-H) Risk Ratio (RR) of 0.92 for Prevention- Reduction - Epithelialization- Vacuum- Environment- Negative pressure- Advanced (PREVENA) (95% CI: 0.67–1.26, I2= 0%, P= 0.6) and 0.76 for Pressure- Incision- Closed- Optimization (PICO) (95% CI: 0.44–1.33, I2= 15%, P= 0.05), with a significant difference among devices (P=0.05).
Conclusion: NPWT reduces the SSI rate in obese women undergoing C-sections, regardless of the type or device used. Economic evaluations are crucial to justify NPWT device costs against expenses for treating surgical infections, supporting its widespread use in infection prevention.
Perceived organizational support and its impact on nurses’ intention to stay in Vietnam: Psychological well-being and organizational commitment as mediators
Authors: Duong Cong Hiep , Ho Yi-Hui , Hoang Thi Kim Thoa
Published: August 2024

Background & Aim: Post the COVID-19 pandemic, there has been an observable escalation in the propensity of nurses to resign from their positions, which exerts substantial pressure on healthcare systems worldwide. Perceived Organizational Support has been acknowledged as a pivotal factor in the retention of nursing personnel after the pandemic. This study aims to provide valuable insights into the intricate interplay between Perceived Organizational Support, Psychological Well-being, Organizational Commitment, and Nurses’ Intention to Stay in Vietnamese healthcare.
Methods & Materials: This study adopted a cross-sectional quantitative design using a structured questionnaire to collect data from diverse professionals in Vietnam through an online platform. Data analysis was conducted using PLS-SEM on a robust dataset of 302 valid observations. A hybrid sampling method combining convenience and snowball techniques was employed. The questionnaire was disseminated via Google Forms during March and April 2024, allowing for an insightful examination of the research phenomena within Vietnam's unique sociocultural context.
Results: The study showed a significant positive impact of Perceived Organizational Support on Psychological Well-being, Organizational Commitment, and Nurses’ Intention to Stay. Perceived Organizational Support directly affects Nurses’ Intention to Stay, and Psychological Well-being emerges as a strong determinant of Nurses’ Intention to Stay and a mediator between Perceived Organizational Support and Nurses’ Intention to Stay.
Conclusion: Healthcare managers play a key role in promoting Nurses’ Intention to Stay by increasing Organizational Support, promoting Psychological Well-being, and enhancing Organizational Commitment. These strategies are critical to maintaining stability within the healthcare organization, addressing nursing turnover, and maintaining a resilient workforce.
Evaluation of Kidney Function in Bipolar Patients: A Cross-Sectional Study
Authors:   Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, Salvador, Bahia, Brazil, Fernandes Santiago , Silva Thiago Cerqueira , Dalallana Caroline , Pinto Antônio Raimundo , Daltro Carla , Scippa Ângela Miranda
Published: August 2024

Bipolar disorder is a chronic disease that represents a significant problem to the affected individual. To date, the mainstay treatment for bipolar disorder consists in mood stabilizers, mainly lithium, which have been linked to acute and chronic kidney injury. To investigate the association between Estimated Glomerular Filtration Rate (eGFR) and sociodemographic and clinical characteristics in a group of patients with bipolar disorder (BD) undergoing lithium treatment, with or without concomitant use of other psychopharmaceuticals. In this cross-sectional study data was collected using the instruments: 1 – Clinical and sociodemographic data questionnaire, developed by the Brazilian Consortium for Bipolar Disorder Research; 2 – Structured Clinical Interview for the DSM-IV Axis I Disorders; 3 – Hamilton’s Rating Scale for Depression, to evaluate depressive symptoms and 4 – Young’s Rating Scale for Mania to evaluate mania symptoms. Renal function was calculated through the CKD/EPI formula for eGFR. 95 patients were included in the final analysis. 26 (27.4%) patients presented reduction in eGFR, 21 (22,1%) with eGFR between 60 to 89 and 5 (5,2%) below 60. Higher serum lithium levels and age were associated with such reduction (β = -18.06 [95% CI: -34.70 to -1.42]); (β = -0.72 (95% CI: -1.10 to -0.33)), respectively. Although lithium is considered the “gold standard” in the treatment of BD, its toxicity and tolerability profile in relation to renal function still needs to be better understood. The results of this study reinforce the idea that periodic control of lithium levels is essential for preserving renal function. Long-term longitudinal studies are needed to assess the relationship between renal function and lithium therapy in BD patients. Keywords Lithium, Bipolar Disorder, Kidney, Renal Insufficiency
SEGURANÇA ALIMENTAR NO CONSUMO DE ÁGUA ENVASADA: UM ESTUDO DE CASO
Authors: Marques dos Santos Yasmin , Cardoso Campos de Assunção Beatriz , De Andrade Tenorio Cavalcanti Camilla , Araújo dos Santos Júnior José , José Isidoro de Araújo Rodrigues Azevedo Andrey , Marques do Nascimento Santos Josineide , Brayner Cavalcanti Freire Bezerra Mariana
Published: August 2024

A monitoração dos recursos hídricos deve ser, pela essencialidade, uma prática prioritária, sendo um desafio na preservação das fontes de distribuição. Características físico-químicas, microbiológicas e organolépticas definem o padrão de potabilidade e consumo. No estudo, foram avaliados parâmetros de qualidade da água mineral envasada em amostras coletadas no Centro de Tecnologia e Geociências da Universidade Federal de Pernambuco. Com auxílio de bomba de sucção, as alíquotas de 500 mL e 100 mL foram coletadas, sendo a última armazenada em bolsa estéril para análise microbiológica. Detector multiparâmetro foi utilizado para os ensaios físico-químicos; meio de cultura em Placa Petrifilm® EC para E. coli e coliformes totais; fotometria de chama para cátions majoritários; sistema FIAlab para ânions e cloreto analisado por titulometria. Os valores médios encontrados para T (ºC), pH, condutividade, STD, salinidade, Ca2+, K+, Na+, Cl-, NO2-, NO3- e SO42- foram de 25,1±0,8ºC; 4,26±0,10; 85,25±1,50 µS; 41,35±0,64 mg/L; 0,04 pg/L; 1,90±0,05 mg/L; 0,7 mg/L; 78,23±4,53 mg/L; 26,2±6,1 mg/L; 0,03±0,03 mg/L; 2,6±0,1 mg/L e 11,4±5,4 mg/L, respectivamente. As análises microbiológicas revelaram ausência de coliformes e E. coli. A rotulagem apresentou as informações obrigatórias e os parâmetros avaliados atendem às RDCs 274/2005 e 717/2022 da ANVISA. Não foram observadas alterações que comprometam o consumo da água investigada.
A ação dos fármacos para o tratamento na Doença de Parkinson e as possíveis alterações no comportamento alimentar: uma Revisão Integrativa
Authors: Mota Fonseca da Silva Fábio Antônio , Monteiro de Oliveira Débora Carla , Barreto Bernadino Kayane Victoria , De Almeida Melo Lyvia Maria , Winkler Amanda de Hollanda , Tenório Cavalcanti Camilla de Andrade , Xavier da Cruz Sara Maria , Leite Celestino Vanessa Ribeiro , Serafim da Silva Lopes Isvânia Maria
Published: August 2024

A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais comum no mundo. O tratamento medicamentoso não cura a patologia, mas atua retardando e reduzindo os sintomas. No entanto, acabam resultam colaterais como os distúrbios de controle de impulso. A alimentação é um dos fatores que pode sofrer influência durante os tratamentos utilizados. No qual, pode resultar em uma maior ingestão e descontrole frente às refeições diárias. O presente trabalho se propõe a avaliar se os remédios mais utilizados no tratamento na DP possuem ligações com o surgimento de modificações alimentares em humanos. A metodologia utilizada consistiu em uma revisão integrativa da literatura. Analisando os resultados é possível verificar uma tendência do uso de Agonistas de Dopamina (AD) e/ou da Levodopa, relacionados ao aumento de tecido adiposo, sejam os fármacos utilizados em associação ou não. Os efeitos negativos podem ser tamanhos, que tem potencial de auxiliar no início de um quadro de transtorno de compulsão alimentar (TCA). Então, para minimizar os danos a saúde do indivíduo, é preciso acompanhar a possível evolução das modificações alimentares ocasionadas por meio dos tratamentos farmacológicos para a DP, avaliando a necessidade de realizar uma troca do tratamento, além da atuação de profissionais da área de saúde, como nutricionistas e psicológicos para evitar um cenário de obesidade.
RELAÇÃO DE GALECTINA 4 E ADENOCARCINOMA DUCTAL PANCREÁTICO: UMA REVISÃO INTEGRATIVA
Authors: Gabriel Ykaro , Germano Joelson , Sibelly Viviane , Cavalcante Celina , Melgarejo Michelle
Published: August 2024

RESUMO
 
O presente estudo tem como objetivo discutir a influência da Galectina-4 (Gal-4) na progressão do Adenocarcinoma Ductal Pancreático (PDAC). Foi utilizado o modelo de revisão integrativa, por meio da revisão de literatura, como abordagem metodológica. A Gal-4, uma proteína ligante de β-galactosídeo, desempenha um papel significativo no câncer pancreático. Expressa em vários tipos de câncer, incluindo colorretal, mama, gástrico, pulmonar e pancreático, a Gal-4 emerge como possível biomarcador e alvo terapêutico. A sua atuação no câncer colorretal, ao inibir a progressão, está em consonância com a sua função no adenocarcinoma ductal pancreático, onde exerce um papel de inibição na migração celular. Mecanismos envolvem modulação de vias Wnt/β-catenina e IL-6/NF-κB/STAT3. A expressão de Gal-4 correlaciona-se com interações célula-tumor e glóbulos vermelhos, indicando implicações na disseminação tumoral. Presente em lesões precursoras e pancreatite crônica, a Gal-4 destaca-se como marcador em estágios iniciais ou inflamatórios. Resultados de modelos e estudos clínicos oferecem insights valiosos referentes à expressão da Gal-4, seus efeitos nas vias de sinalização celular e possíveis correlações com parâmetros clínicos relevantes no contexto do PDAC. Investigações futuras devem elucidar mecanismos, interações e relevância clínica, fundamentando estratégias terapêuticas e diagnósticas eficazes no PDAC.
 
Palavras-Chave: Câncer, Galectinas, PDAC.