bluuebunny/crossref_metadata_2025 huggingface dataset:
A single nucleotide substitution in the coding region of Ogura male sterile gene, orf138, determines effectiveness of a fertility restorer gene, Rfo, in radish
Authors: Yamagishi Hiroshi , Jikuya Megumi , Okushiro Kanako , Hashimoto Ayako , Fukunaga Asumi , Takenaka Mizuki , Terachi Toru
Published: March 2021

Cytoplasmic male sterility (CMS) observed in many plants leads defect in the production of functional pollen, while the expression of CMS is suppressed by a fertility restorer gene in the nuclear genome. Ogura CMS of radish is induced by a mitochondrial orf138, and a fertility restorer gene, Rfo, encodes a P-type PPR protein, ORF687, acting at the translational level. But, the exact function of ORF687 is still unclear. We found a Japanese variety showing male sterility even in the presence of Rfo. We examined the pollen fertility, Rfo expression, and orf138 mRNA in progenies of this variety. The progeny with Type H orf138 and Rfo showed male sterility when their orf138 mRNA was unprocessed within the coding region. By contrast, all progeny with Type A orf138 were fertile though orf138 mRNA remained unprocessed in the coding region, demonstrating that ORF687 functions on Type A but not on Type H. In silico analysis suggested a specific binding site of ORF687 in the coding region, not the 5′ untranslated region estimated previously, of Type A. A single nucleotide substitution in the putative binding site diminishes affinity of ORF687 in Type H and is most likely the cause of the ineffectiveness of ORF687. Furthermore, fertility restoration by RNA processing at a novel site in some progeny plants indicated a new and the third fertility restorer gene, Rfs, for orf138. This study clarified that direct ORF687 binding to the coding region of orf138 is essential for fertility restoration by Rfo.
Evaluation on the Effect of Pressure Transients on Rock Joints in Unlined Hydropower Tunnels Using Numerical Simulation
Authors: Neupane Bibek , Panthi Krishna Kanta
Published: March 2021

Frequent pressure transients are identified as the cause of block failures in many unlined hydropower tunnels. The primary design objective of such tunnels is to prevent hydraulic jacking at design static pressure and mass oscillation but neglects the effect of short transients, i.e., water hammer. The issue has not been studied from the perspective of hydro-mechanical interactions due to frequent pore pressure changes in the rock mass. This article mainly focuses on the effect of pressure transients at different static heads, or different effective normal stresses across the joints and the effect of time period of pressure transient. Further, the change in such behaviour due to different mechanical properties of rock joints, such as stiffness, friction angle and dilation, is investigated. Numerical simulations of observed pore pressure response in the rock mass during a pressure transient are carried out using distinct element code 3DEC. The results show that relative joint deformation due to short pressure transients are the highest when joint normal stresses are 1.5–2.5 times higher than static water pressure in the tunnel and thus the vulnerability to weakening of such joints by hydraulic fatigue is higher. Further, results show that water hammers can travel up to 4 m into the rock mass even in stiff joint conditions and sufficiently high normal stresses. Results further indicate that the hydraulic impact due to water hammer is smaller as compared to mass oscillation. It is concluded that water hammers, wherever applicable along the waterway, can still contribute to hydraulic fatigue of rock joints in addition to the effect of mass oscillation and cannot be neglected when pressure transients occur frequently. Tunnel filling/dewatering and mass oscillations cause macroscopic joint displacements or block movements over long-term operation which is the major cause of block falls in unlined pressure tunnels.
RETRACTED ARTICLE: Forecasting major impacts of COVID-19 pandemic on country-driven sectors: challenges, lessons, and future roadmap
Authors: Kumar Saket , Viral Rajkumar , Deep Vikas , Sharma Purushottam , Kumar Manoj , Mahmud Mufti , Stephan Thompson
Published: March 2021

The pandemic caused by the coronavirus disease 2019 (COVID-19) has produced a global health calamity that has a profound impact on the way of perceiving the world and everyday lives. This has appeared as the greatest threat of the time for the entire world in terms of its impact on human mortality rate and many other societal fronts or driving forces whose estimations are yet to be known. Therefore, this study focuses on the most crucial sectors that are severely impacted due to the COVID-19 pandemic, in particular reference to India. Considered based on their direct link to a country’s overall economy, these sectors include economic and financial, educational, healthcare, industrial, power and energy, oil market, employment, and environment. Based on available data about the pandemic and the above-mentioned sectors, as well as forecasted data about COVID-19 spreading, four inclusive mathematical models, namely—exponential smoothing, linear regression, Holt, and Winters, are used to analyse the gravity of the impacts due to this COVID-19 outbreak which is also graphically visualized. All the models are tested using data such as COVID-19 infection rate, number of daily cases and deaths, GDP of India, and unemployment. Comparing the obtained results, the best prediction model is presented. This study aims to evaluate the impact of this pandemic on country-driven sectors and recommends some strategies to lessen these impacts on a country’s economy.
The impact of school closure and social isolation on children in vulnerable families during COVID-19: a focus on children’s reactions
Authors: Larsen Linda , Helland Maren Sand , Holt Tonje
Published: March 2021

For children the consequences of the COVID-19 public health measures may have long-term effects into adulthood. By exploring children’s reactions more broadly, we are better placed to understanding the breadth of implications of home school and social isolation under COVID-19. The present study explored how COVID-19 related variables, namely, home school experience, child perceived family stress and instability, screen time use, missing friends and worry about virus infection are associated with children’s emotional, somatic/cognitive and worry reactions, respectively. A total of 442 children (M = 11.43 years, SD = 2.59) from the longitudinal FamilieForSK-study participated and a series of hierarchical linear regression models were applied controlling for background variables including children’s psychological vulnerability. Results showed significant associations between all COVID-19 related predictors, except screen time use, and the three outcomes. Family stress and instability had the strongest effects with standardised betas ranging from .356 to .555 and collectively, predictors explained between 20.7 and 44.1% of variance in outcomes. Furthermore, several associations were moderated by age and older children were more negatively impacted (i.e., higher level of reported reactions). The present study provides more conclusive evidence of the effects of home school and social isolation under COVID-19 on children. It also exemplifies the importance of focusing on children’s reactions more broadly, as there was evidence that children on average had fewer emotional reactions compared to before the pandemic.
Simulative investigation of wind turbine gearbox loads during power converter fault
Authors: Röder Julian , Jacobs Georg , Duda Tobias , Bosse Dennis , Herzog Fabian
Published: March 2021

Three phase short circuit power converter faults in wind turbines (WT) result in highly dynamic generator torque reversals, which lead to load reversals within the drivetrain. Dynamic load reversals in combination with changing rotational speeds are, for example, critical for smearing within roller bearings. Therefore, an investigation of the correlation between three phase short circuit converter faults and drivetrain component failures is necessary.

Due to the risk of damage and the resulting costs, it is not economically feasible to extensively investigate three phase short circuit converter faults on test benches. Valid WT drivetrain models can be used instead. A WT drivetrain model, which has been developed and validated in a national project at the CWD, is used and a three phase short circuit converter fault is implemented. In this paper, the resulting torque load on the drivetrain for a three phase short circuit converter fault in rated power production is presented. This converter fault leads to a highly dynamic reversing electromagnetic torque which exceeds the rated torque by a factor of three. As a result the load on the rotor side high speed shaft (HSS) bearing oscillates and increases by around 15 per cent compared to rated power production. Simultaneously the rotational velocity of the HSS oscillates with an amplitude of 10 rpm. Therefore an increase in the risk of smearing is expected.
Incremental communication patterns in online social groups
Authors: Michienzi Andrea , Guidi Barbara , Ricci Laura , De Salve Andrea
Published: March 2021

In the last decades, temporal networks played a key role in modelling, understanding, and analysing the properties of dynamic systems where individuals and events vary in time. Of paramount importance is the representation and the analysis of Social Media, in particular Social Networks and Online Communities, through temporal networks, due to their intrinsic dynamism (social ties, online/offline status, users’ interactions, etc..). The identification of recurrent patterns in Online Communities, and in detail in Online Social Groups, is an important challenge which can reveal information concerning the structure of the social network, but also patterns of interactions, trending topics, and so on. Different works have already investigated the pattern detection in several scenarios by focusing mainly on identifying the occurrences of fixed and well known motifs (mostly, triads) or more flexible subgraphs. In this paper, we present the concept on the Incremental Communication Patterns, which is something in-between motifs, from which they inherit the meaningfulness of the identified structure, and subgraph, from which they inherit the possibility to be extended as needed. We formally define the Incremental Communication Patterns and exploit them to investigate the interaction patterns occurring in a real dataset consisting of 17 Online Social Groups taken from the list of Facebook groups. The results regarding our experimental analysis uncover interesting aspects of interactions patterns occurring in social groups and reveal that Incremental Communication Patterns are able to capture roles of the users within the groups.
Computational model of damage-induced growth in soft biological tissues considering the mechanobiology of healing
Authors: Gierig Meike , Wriggers Peter , Marino Michele
Published: March 2021

Healing in soft biological tissues is a chain of events on different time and length scales. This work presents a computational framework to capture and couple important mechanical, chemical and biological aspects of healing. A molecular-level damage in collagen, i.e., the interstrand delamination, is addressed as source of plastic deformation in tissues. This mechanism initiates a biochemical response and starts the chain of healing. In particular, damage is considered to be the stimulus for the production of matrix metalloproteinases and growth factors which in turn, respectively, degrade and produce collagen. Due to collagen turnover, the volume of the tissue changes, which can result either in normal or pathological healing. To capture the mechanisms on continuum scale, the deformation gradient is multiplicatively decomposed in inelastic and elastic deformation gradients. A recently proposed elasto-plastic formulation is, through a biochemical model, coupled with a growth and remodeling description based on homogenized constrained mixtures. After the discussion of the biological species response to the damage stimulus, the framework is implemented in a mixed nonlinear finite element formulation and a biaxial tension and an indentation tests are conducted on a prestretched flat tissue sample. The results illustrate that the model is able to describe the evolutions of growth factors and matrix metalloproteinases following damage and the subsequent growth and remodeling in the respect of equilibrium. The interplay between mechanical and chemo-biological events occurring during healing is captured, proving that the framework is a suitable basis for more detailed simulations of damage-induced tissue response.
Exploring economic and legal barriers to commercial aquaponics in the EU through the lens of the UK and policy proposals to address them
Authors: Cammies Christopher , Mytton David , Crichton Rosemary
Published: March 2021

Aquaponics is a food production system which connects recirculating aquaculture (fish) to hydroponics (plants) systems. Although aquaponics has the potential to improve soil conditions by reducing erosion and nutrient loss and has been shown to reduce food production related carbon emissions by up to 73%, few commercial aquaponics projects in the EU and UK have been successful. Key barriers to commercial success are insufficient initial investment, an uncertain and complex regulatory environment, and the lack of projects operating on a large scale able to demonstrate profitability. In this paper, we use the UK as a case study to discuss the legal and economic barriers to the success of commercial aquaponics in the EU. We also propose three policies: (1) making aquaponics eligible for the new system of Environmental Land Management grants; (2) making aquaponics eligible for organic certification; and (3) clarifying and streamlining the aquaponics licence application process. The UK’s departure from the EU presents a unique opportunity to review agricultural regulations and subsidies, which in turn could provide evidence that similar reforms are needed in the EU.
Trace element contamination in the mine-affected stream sediments of Oued Rarai in north-western Tunisia: a river basin scale assessment
Authors: Ayari Jamel , Barbieri Maurizio , Agnan Yannick , Sellami Ahmed , Braham Ahmed , Dhaha Faouzi , Charef Abdelkarim
Published: March 2021

High-quality and accurate environmental investigations are essential for the evaluation of contamination and subsequent decision-making processes. A combination of environmental geochemical indices, multivariate analyses and geographic information system approach was successfully used to assess contamination status and source apportionment of trace elements (Ag, As, Cd, Cr, Cu, Hg, Ni, Pb, Sb, V and Zn) in surface stream sediments from the Oued Rarai basin in north-western Tunisia, containing various metal and metalloid ores. The contamination level reported in this study indicates a non-negligible potential ecological risk, mainly related to sediment transport along the river. Antimony (concentrations ranged from 0.02 to 297 mg kg−1 and Igeo > 5), arsenic (from 0.5 to 1490 mg kg−1 and Igeo > 5), lead (from 2.9 to 5150 mg kg−1 and Igeo > 5) mercury (from 0.05 to 54.4 mg kg−1 and Igeo > 5) and silver (from 0.05 to 9.4 mg kg−1 and Igeo > 5) showed the most crucial contamination. Besides, potential ecological risk index values were maximum for arsenic with a median of 302, indicating a very high to serious ecological risk (> 160). Results from correlation analysis and principal component analysis revealed three main geochemical associations related to lithologic, tectonic and anthropogenic sources. V, Cr and Cu mainly originated from natural bedrock and soil. Ag and Cd were more controlled by both natural and mining enrichments. Mercury and Pb were mostly influenced by the ancient ore-related activities at the Oued Rarai site and north-east–south-west trending faults. Finally, Sb, As, Ni and Zn were largely controlled by the siliciclastic continental Neogene sequences. Finally, the physical and chemical dynamics of the watershed system, lithological properties, mineralisation, tectonic settings and mobilisation of subsurface sediments largely controlled both concentrations and spatial patterns of trace elements in the study basin. These results need to be considered in the strategies of suitable environmental management at former and current mining sites in north-western Tunisia.
Brief Report: Autism-Specific College Support Programs: Differences Across Geography and Institutional Type
Authors: Nachman Brett Ranon , McDermott Catherine Tobin , Cox Bradley E.
Published: March 2021

Many postsecondary institutions have begun their own Autism-Specific College Support Programs (ASPs) to integrate the emergence of autistic students into college and offer supports aiding their success (Longtin in J Postsecond Educ Disabil 27(1):63–72, 2014), yet little is known about these programs. We conducted an exhaustive, year-long search of all postsecondary institutions in the United States to identify all ASPs. Although we identified a total of 74 programs located in 29 states, our analyses suggest these are unavailable to students in large portions of the country. When they are available, these programs appear to be disproportionately located at 4-year institutions, public institutions, and in the Mid-East. Our study highlights inequities based on institutional type and geography, as well as offers a complete public list of ASPs.
Parent Support Programmes for Families Who are Immigrants: A Scoping Review
Authors: Hamari Lotta , Konttila Jenni , Merikukka Marko , Tuomikoski Anna-Maria , Kouvonen Petra , Kurki Marjo
Published: March 2021

Parental support is of paramount importance in the promotion of positive parenting, strengthening parenthood and protecting children from disadvantages due to immigration experiences. The aim was to describe what is known about parent support programmes targeted to families who are immigrants. Electronic databases and the grey literature were systematically and comprehensively searched with no time/language restrictions. JBI approach and PRISMA-ScR were used to guide the review. N = 88 articles were sourced. Interventions were targeted to improve parental practices, skills and family wellbeing, usually through group-based methods. Most interventions included components of positive parenting and family communication. Identifying the needs of the target group and cultural tailoring were reported to be highly important in gaining acceptability, promoting engagement and producing benefits. Parent support programmes for families who are immigrants potentially improve positive parental practices and families’ wellbeing. There are many applicable and effective interventions to be exploited.
Quenched Local Convergence of Boltzmann Planar Maps
Authors: Stufler Benedikt
Published: March 2021

Stephenson (2018) established annealed local convergence of Boltzmann planar maps conditioned to be large. The present work uses results on rerooted multi-type branching trees to prove a quenched version of this limit.
Emerging Neoliberal Academic Identities: Looking Beyond Homo economicus
Authors: Skea Claire
Published: March 2021

In this article, I deal with the notion of ‘academic identity’ holistically, seeking to bring together the teacher and researcher roles of academics in the neoliberal university. The article begins from the perspective of early-career academics who occupy the majority of fixed-term, teaching-only contracts in Higher Education, arguing that such casualisation of academic labour entrenches the role of the academic asHomo economicus. Drawing on the work of Foucault, I demonstrate how a neoliberal governmentality is now not only exerted upon academics from without, but increasingly they are subjecting themselves to the logic of efficiency and effectiveness too. The neoliberal governmentality of the university thus influences and shapes academic subjectivities, such that what it means tobean academic is confined to this marketised logic. Despite the pressures placed on academics to ‘produce’ measurable outputs and demonstrate their impact, I argue that moving beyondHomo economicusis possible, arguing instead for a re-claiming of ‘the academic’ asHomo academicus. The idea ofHomo academicuscan only be supported when three conditions are present: collegiality is afforded greater importance than competition; the discourses of ‘productivity’ and performativity are balanced against simply ‘doing good work well’ (Pirrie in Virtue and the quiet art of scholarship, Routledge, London, 2019), and; academics are mindful to practice the ‘quieter’ intellectual virtues, including the virtue of ‘unknowing’ (Smith in J Philos Educ 50:272–284, 2016).
Necessary and sufficient conditions for pairwise majority decisions on path-connected domains
Authors: Karmokar Madhuparna , Roy Souvik , Storcken Ton
Published: March 2021

In this paper, we consider choice functions that are unanimous, anonymous, symmetric, and group strategy-proof and consider domains that are single-peaked on some tree. We prove the following three results in this setting. First, there exists a unanimous, anonymous, symmetric, and group strategy-proof choice function on a path-connected domain if and only if the domain is single-peaked on a tree and the number of agents is odd. Second, a choice function is unanimous, anonymous, symmetric, and group strategy-proof on a single-peaked domain on a tree if and only if it is the pairwise majority rule (also known as the tree-median rule) and the number of agents is odd. Third, there exists a unanimous, anonymous, symmetric, and strategy-proof choice function on a strongly path-connected domain if and only if the domain is single-peaked on a tree and the number of agents is odd. As a corollary of these results, we obtain that there exists no unanimous, anonymous, symmetric, and group strategy-proof choice function on a path-connected domain if the number of agents is even.
Understanding the Role of Outsiders in Community-Based Development Interventions: A Framework with Findings from Iran
Authors: Naficy Alireza , Bergh Sylvia I. , Akhavan Alavi Seyyed Hossain , Maleki Ali , Mirehei Mohammad
Published: March 2021

This article analyzes various roles of development practitioners (called outsiders) in five different cases of community-based development (CBD) in rural Iran. It provides a review of the literature on CBD and identifies three main types of roles fulfilled by outsiders to support indigenous development processes. These include preparing the ground, activating community-based organizations as participatory institutions, and taking on the role of brokers who bridge the gap between the local community and outside institutions—especially the state and market. From the analysis of empirical qualitative data collected during fieldwork in Iran, the article concludes that while the roles played by the outsiders in CBD interventions there correspond mostly to those identified in the literature, there are differences in their strategies of intervention and activities under each role which correspond with their contextual contingencies. Recognizing this variation is needed to deepen the understanding of CBD practices and help practitioners think about alternative perspectives and approaches.
Collaboration, Co-Optation or Navigation? The Role of Civil Society in Disaster Governance in India
Authors: Syal Reetika , van Wessel Margit , Sahoo Sarbeswar
Published: March 2021

Existing research on civil society organizations (CSOs) facing restricted civic space largely focuses on the crackdown on freedoms and CSOs’ strategies to handle these restrictions, often emphasizing impact on their more confrontational public roles. However, many CSOs shape their roles through collaborative relations with government. Drawing on interviews with state agencies and CSOs, this article analyes state–CSO collaboration in the restricted civic space context of disaster risk reduction in India. Findings are that the shaping of CSOs’ roles through collaboration under conditions of restricted civic space is only partly defined by the across-the-board restrictive policies that have been the focus of much existing research on restricted civic space and its implications for CSOs. Interplay at the level of individual state agencies and CSOs, based on mutual perceptions, diverse organization-level considerations and actions, and evolving relations, shape who collaborates with whom and to what effect. This article thus stresses interplay and agency, moving away from simple understandings of co-optation, and calling for a more differentiated approach to the study of state–civil society collaboration under conditions of restricted civic space, with close attention to navigation.
The accuracy of crime statistics: assessing the impact of police data bias on geographic crime analysis
Authors: Buil-Gil David , Moretti Angelo , Langton Samuel H.
Published: March 2021

Objectives

Police-recorded crimes are used by police forces to document community differences in crime and design spatially targeted strategies. Nevertheless, crimes known to police are affected by selection biases driven by underreporting. This paper presents a simulation study to analyze if crime statistics aggregated at small spatial scales are affected by larger bias than maps produced for larger geographies.

Methods

Based on parameters obtained from the UK Census, we simulate a synthetic population consistent with the characteristics of Manchester. Then, based on parameters derived from the Crime Survey for England and Wales, we simulate crimes suffered by individuals, and their likelihood to be known to police. This allows comparing the difference between all crimes and police-recorded incidents at different scales.

Results

Measures of dispersion of the relative difference between all crimes and police-recorded crimes are larger when incidents are aggregated to small geographies. The percentage of crimes unknown to police varies widely across small areas, underestimating crime in certain places while overestimating it in others.

Conclusions

Micro-level crime analysis is affected by a larger risk of bias than crimes aggregated at larger scales. These results raise awareness about an important shortcoming of micro-level mapping, and further efforts are needed to improve crime estimates.
A Note on the Likelihood Ratio Test in High-Dimensional Exploratory Factor Analysis
Authors: He Yinqiu , Wang Zi , Xu Gongjun
Published: March 2021

The likelihood ratio test is widely used in exploratory factor analysis to assess the model fit and determine the number of latent factors. Despite its popularity and clear statistical rationale, researchers have found that when the dimension of the response data is large compared to the sample size, the classical Chi-square approximation of the likelihood ratio test statistic often fails. Theoretically, it has been an open problem when such a phenomenon happens as the dimension of data increases; practically, the effect of high dimensionality is less examined in exploratory factor analysis, and there lacks a clear statistical guideline on the validity of the conventional Chi-square approximation. To address this problem, we investigate the failure of the Chi-square approximation of the likelihood ratio test in high-dimensional exploratory factor analysis and derive the necessary and sufficient condition to ensure the validity of the Chi-square approximation. The results yield simple quantitative guidelines to check in practice and would also provide useful statistical insights into the practice of exploratory factor analysis.
Robotic infant surgery with 3 mm instruments: a study in piglets of less than 10 kg body weight
Authors: Krebs Thomas F. , Egberts Jan-Hendrik , Lorenzen Ulf , Krause Martin F. , Reischig Katja , Meiksans Roberts , Baastrup Jonas , Meinzer Andreas , Alkatout Ibrahim , Cohrs Gesa , Wieker Henning , Lüthje Annette , Vieten Sarah , Schultheiss Gerhard , Bergholz Robert
Published: March 2021

No data exist concerning the appication of a new robotic system with 3 mm instruments (Senhance®, Transenterix) in infants and small children. Therefore, the aim of this study was to test the system for its feasibility, performance and safety of robotic pediatric abdominal and thoracic surgery in piglets simulating infants with a body weight lower than 10 kg. 34 procedures (from explorative laparoscopy to thoracoscopic esophageal repair) were performed in 12 piglets with a median age of 23 (interquartile range: 12–28) days and a median body weight of 6.9 (6.1–7.3) kg. The Senhance® robotic system was used with 3 mm instruments, a 10 mm 3D 0° or 30° videoscope and advanced energy devices, the setup consisted of the master console and three separate arms. The amount, size, and position of the applied ports, their distance as well as the distance between the three operator arms of the robot, external and internal collisions, and complications of the procedures were recorded and analyzed. We were able to perform all planned surgical procedures with 3 mm robotic instruments in piglets with a median body weight of less than 7 kg. We encountered two non-robot associated complications (bleeding from the inferior caval and hepatic vein) which led to termination of the live procedures. Technical limitations were the reaction time and speed of robotic camera movement with eye tracking, the excessive bending of the 3 mm instruments and intermittent need of re-calibration of the fulcrum point. Robotic newborn and infant surgery appears technically feasible with the Senhance® system. Software adjustments for camera movement and sensitivity of the fulcrum point calibration algorithm to adjust for the increased compliance of the abdominal wall of infants, therefore reducing the bending of the instruments, need to be implemented by the manufacturer as a result of our study. To further evaluate the Senhance® system, prospective trials comparing it to open, laparoscopic and other robotic systems are needed.
Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics
Authors: Charvet Benjamin , Pierquin Justine , Brunel Joanna , Gorter Rianne , Quétard Christophe , Horvat Branka , Amor Sandra , Portoukalian Jacques , Perron Hervé
Published: March 2021

In multiple sclerosis (MS), human endogenous retrovirus W family (HERV-W) envelope protein, pHERV-W ENV, limits remyelination and induces microglia-mediated neurodegeneration. To better understand its role, we examined the soluble pHERV-W antigen from MS brain lesions detected by specific antibodies. Physico-chemical and antigenic characteristics confirmed differences between pHERV-W ENV and syncytin-1. pHERV-W ENV monomers and trimers remained associated with membranes, while hexamers self-assembled from monomers into a soluble macrostructure involving sulfatides in MS brain. Extracellular hexamers are stabilized by internal hydrophobic bonds and external hydrophilic moieties. HERV-W studies in MS also suggest that this diffusible antigen may correspond to a previously described high-molecular-weight neurotoxic factor secreted by MS B-cells and thus represents a major agonist in MS pathogenesis. Adapted methods are now needed to identify encoding HERV provirus(es) in affected cells DNA. The properties and origin of MS brain pHERV-W ENV soluble antigen will allow a better understanding of the role of HERVs in MS pathogenesis. The present results anyhow pave the way to an accurate detection of the different forms of pHERV-W ENV antigen with appropriate conditions that remained unseen until now.
The Illusions of the Modern Synthesis
Authors: Noble Denis
Published: March 2021

The Modern Synthesis has dominated biology for 80 years. It was formulated in 1942, a decade before the major achievements of molecular biology, including the Double Helix and the Central Dogma. When first formulated in the 1950s these discoveries and concepts seemed initially to completely justify the central genetic assumptions of the Modern Synthesis. The Double Helix provided the basis for highly accurate DNA replication, while the Central Dogma was viewed as supporting the Weismann Barrier, so excluding the inheritance of acquired characteristics. This article examines the language of the Modern Synthesis and reveals that it is based on four important misinterpretations of what molecular biology had shown, so forming the basis of the four Illusions: 1. Natural Selection; 2. The Weismann Barrier; 3. The Rejection of Darwin’s Gemmules; 4. The Central Dogma. A multi-level organisation view of biology avoids these illusions through the principle of biological relativity. Molecular biology does not therefore confirm the assumptions of the Modern Synthesis.
Management of superficial and deep surgical site infection: an international multidisciplinary consensus
Authors: Sganga Gabriele , Baguneid Mohamed , Dohmen Pascal , Giamarellos-Bourboulis Evangelos J. , Romanini Emilio , Vozikis Athanassios , Eckmann Christian
Published: March 2021

Surgical site infections represent a considerable burden for healthcare systems. To obtain a consensus on the impact and future clinical and economic needs regarding SSI management in an era of multidrug resistance. A modified Delphi method was used to obtain consensus among experts from five European countries. The Delphi questionnaire was assembled by a steering committee, verified by a panel of experts and administered to 90 experts in 8 different surgical specialities (Abdominal, Cancer, Cardiac, General surgery, Orthopaedic, Thoracic, Transplant and Vascular and three other specialities (infectious disease, internal medicine microbiology). Respondents (n = 52) reached consensus on 62/73 items including that resistant pathogens are an increasing matter of concern and increase both treatment complexity and the length of hospital stay. There was strong positive consensus on the cost-effectiveness of early discharge (ED) programs, improvement of quality of life with ED and association between increased length of stay and economic burden to the hospital. However, established ED protocols were not widely available in their hospitals. Respondents expressed a positive consensus on the usefulness of antibiotics that allow ED. Surgeons are aware of their responsibility in an interdisciplinary team for the treatment of SSI, and of the impact of multidrug-resistant bacteria in the context of SSI. Reducing the length of hospital stays by applying ED protocols and implementing new treatment alternatives is crucial to reduce harm to patients and costs for the hospital.
Distal renal tubular acidosis: a systematic approach from diagnosis to treatment
Authors: Giglio Sabrina , Montini Giovanni , Trepiccione Francesco , Gambaro Giovanni , Emma Francesco
Published: March 2021

Renal tubular acidosis (RTA) comprises a group of disorders in which excretion of hydrogen ions or reabsorption of filtered HCO3 is impaired, leading to chronic metabolic acidosis with normal anion gap. In the current review, the focus is placed on the most common type of RTA, Type 1 RTA or Distal RTA (dRTA), which is a rare chronic genetic disorder characterized by an inability of the distal nephron to secrete hydrogen ions in the presence of metabolic acidosis. Over the years, knowledge of the molecular mechanisms behind acid secretion has improved, thereby greatly helping the diagnosis of dRTA. The primary or inherited form of dRTA is mostly diagnosed in infancy, childhood, or young adulthood, while the acquired secondary form, as a consequence of other disorders or medications, can happen at any age, although it is more commonly seen in adults. dRTA is not as “benign” as previously assumed, and can have several, highly variable long-term consequences. The present review indeed reports and summarizes both clinical symptoms and diagnosis, long-term outcomes, genetic inheritance, epidemiology and current treatment options, with the aim of shedding more light onto this rare disorder. Being a chronic condition, dRTA also deserves attention in the transition between pediatric and adult nephrology care, and as a rare disease it has a place in the European and Italian rare nephrological diseases network.
Estimate on the Dimension of the Singular Set of the Supercritical Surface Quasigeostrophic Equation
Authors: Colombo Maria , Haffter Silja
Published: March 2021

We consider the SQG equation with dissipation given by a fractional Laplacian of order $$\alpha <\frac{1}{2}$$

α
<

1
2

. We introduce a notion of suitable weak solution, which exists for every $$L^2$$

L
2

initial datum, and we prove that for such solution the singular set is contained in a compact set in spacetime of Hausdorff dimension at most $$\frac{1}{2\alpha } \left( \frac{1+\alpha }{\alpha } (1-2\alpha ) + 2\right) $$

1

2
α

1
+
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1
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2
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)

+
2

.
Responding to the COVID-19 emergency: student and academic staff perceptions of academic integrity in the transition to online exams at three Australian universities
Authors: Reedy Alison , Pfitzner Darius , Rook Laura , Ellis Leonie
Published: March 2021

This paper explores the perceptions of academic staff and students to student cheating behaviours in online exams and other online assessment formats. The research took place at three Australian universities in July and August 2020 during the emergency transition to online learning and assessment in response to the COVID-19 pandemic. The study sought to inform decision making about the future of online exams at the participating universities. Quantitative and qualitative data were collected using online surveys. The findings of the study led to seven key observations, most notably the need to redefine the characteristics of academic misconduct to account for changes wrought to examinations in a digital world. The study concludes with lessons learned in relation to enhancing academic integrity in digital examinations and assessments.
Simultaneous phycoremediation of petrochemical wastewater and lipid production by Chlorella vulgaris
Authors: Madadi Rozita , Zahed Mohammad Ali , Pourbabaee Ahmad Ali , Tabatabaei Meisam , Naghavi Mohammad Reza
Published: March 2021

A novel strategy of using microalgaeChlorella vulgarisfor simultaneous bio-treatment of petrochemical wastewater and lipid production was developed in the present study. Phycoremediation was carried out in 30 days. The profile of fatty acids was identified, and the specifications of biodiesel including saponification value, iodine value, cetane number, long-chain saturated factor, cold filter plugging point, cloud point, allylic position equivalent and bis-allylic position equivalent were predicted by BiodieselAnalyzer® software. Besides, polycyclic aromatic hydrocarbons were determined in both wastewater samples and produced lipid. The observed data showed that biodiesel fromC. vulgariswas superior to petrodiesel in terms of suitability in diesel engines. Moreover, contamination of petrochemical wastewater can influence the expression of a variety of genes in algae. To investigate the effectiveness of contamination on the expression of lipid synthesis as well as three photosynthesis genes, a real-time polymerase chain reaction assay was used to quantify transcript levels ofPsaB(photosystem I reaction center protein subunit B),psbC(an integral membrane protein component of photosystem II), andrbcL(a large subunit of ribulose-1,5-bisphosphate carboxylase oxygenase). Furthermore, the gene expression level ofaccD(acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic) was studied to discover the effect of wastewater on lipid production. The results showed that when diluted petrochemical wastewater (50%) was used as a media forC. vulgariscultivation, these genes expression significantly increased. For 50% diluted wastewater, the maximum removal of BOD, COD, total nitrogen, and total phosphor has been 30.36%, 10.89%, 69.89%, and 92.59%, respectively.
Investigating the Role of Product Assortment in Technology-Enabled Sales Platforms
Authors: Thomas Jacquelyn S. , Jap Sandy D. , Dillon William R. , Briesch Richard A.
Published: March 2021

Throughout a distribution channel, multiple sales platforms and technologies are leveraged to expand market reach and manage offering assortments. Yet, the literature is limited on how buyers who are channel intermediaries make purchase decisions across sales platforms particularly when platforms vary in their degree of technology enablement. This research investigates how B2B buyers respond to the offering, in terms of numerical assortment and quality, when the sales environments vary in their level of technology enablement. We examine the buyer's sales platform choice, purchase quantity, and tackle the seller's challenge of assortment integration. Buyers have a choice of purchasing from a low-tech platform where buyers are in-person and an auction determines sales, an Internet-enabled platform where remotely located buyers are price takers, and a hybrid platform that has a high level of technology enablement such that co-located and remotely located potential buyers simultaneously bid on the offering. A Hidden Markov Model captures the impact of different need states on buyers’ decisions. Our findings: (1) uncover three distinct buyer profiles that have unique sales platform preferences and multiplatform buying tendencies that relate to their comfort with technology-enabled markets, (2) show that buyers exhibit distinct and dynamic needs that affect their sales platform choices and response to the platform offerings, (3) reveal that buyers experience diminishing returns to product assortment and condition at varying rates depending on their need state. Supporting our key findings, we find evidence of similar behaviors among consumers in a B2C multichannel context that includes an omnichannel. Additionally, we offer recommendations for B2B sellers regarding allocating and adjusting assortments to drive sales platform choice and revenues per buyer.
Language and Social Minds
Authors: Tantucci Vittorio
Published: March 2021

Combining theory from cognitive semantics and pragmatics, this book offers both a new model and a new usage-based method for the understanding of intersubjectivity, and how social cognition is expressed linguistically at different levels of complexity. Bringing together ideas from linguistics and theory of mind, Tantucci demonstrates the way in which speakers constantly monitor and project their interlocutor's reactions to what is being said, and sets out three distinct categories of social cognition in first language acquisition and language change. He also shows how this model can be applied in different settings and includes a range of examples from languages across the globe, to demonstrate the cross-linguistic universality of the model. Additionally the book offers insights into the gradient dimension of intersubjectivity in language evolution and across the autistic spectrum. Original and innovative, it will be invaluable for researchers in cognitive linguistics, pragmatics, historical linguistics, applied linguistics and cognitive psychology.
The Foldcourse and East Anglian Agriculture and Landscape, 1100–1900
Authors: Belcher John
Published: March 2021

First survey of one of the most important pre-modern farming systems, and its effects on society and landscape.
Claw Toe: Anatomic Guide for Injection of Botulinum Toxin into Foot Muscles
Authors: Takekawa Toru , Takagi Satoshi , Kitajima Tomohide , Sato Tomoharu , Kinoshita Kazuo , Abo Masahiro
Published: March 2021

Background:

Poor response to injection of botulinum toxin (BoNT) into the flexor digitorum longus (FDL) muscle has been reported especially in patients with claw foot deformity. We previously advocated BoNT injection into the flexor hallucis longus (FHL) muscle in such patients. Here, we determined the functional and anatomical relationships between FHL and FDL.

Methods:

Toe flexion pattern was observed during electrical stimulation of FHL and FDL muscles in 31 post-stroke patients with claw-foot deformity treated with BoNT. The FHL and FDL tendon arrangement was also studied in five limbs of three cadavers.

Results:

Electrical stimulation of the FHL muscle elicited big toe flexion in all 28 cases examined and second toe in 25, but the response was limited to the big toe in 3. FDL muscle stimulation in 29 patients elicited weak big toe flexion in 1 and flexion of four toes (2nd to 5th) in 16 patients. Cadaver studies showed division of the FHL tendon with branches fusing with the FDL tendon in all five limbs examined; none of the tendons was inserted only in the first toe. No branches of the FDL tendon merged with the FHL tendon.

Conclusion:

Our results showed coupling of FHL and FDL tendons in most subjects. Movements of the second and third toes are controlled by both the FDL and FHL muscles. The findings highlight the need for BoNT injection in both the FDL and FHL muscles for the treatment of claw-toe deformity.
The argument for rapid influenza polymerase chain reaction (PCR) during the COVID-19 pandemic: Quicker turnaround times correlated with decreased antimicrobial use, reduced admission rates, and shorter length of stay
Authors: Sandhu Avnish K. , LeRose Jennifer J. , Garg Alpana , Polistico Jordan , Chopra Teena
Published: March 2021

The innovation of rapid influenza polymerase chain reaction (XT-PCR) has allowed quick, highly sensitive test results. Consequently, physicians can differentiate influenza from other respiratory illnesses and rapidly initiate treatment. We examined the effect of implementing XT-PCR on antimicrobial use, admission rates, and length of stay at a tertiary healthcare system.
Aboriginal student engagement and success in Kimberley tertiary education
Authors: Guenther John , Dwyer Anna , Wooltorton Sandra , Wilks Judith
Published: March 2021

Abstract
Over recent years, considerable effort has been put into increasing Aboriginal and Torres Strait Islander (First Nations) participation in higher education. While there are signs that enrolments are increasing, the sustained engagement and successful completion of higher education remains challenging, particularly in remote locations. With this in mind, a collaborative research project among researchers from three northern Australian tertiary education institutions was designed to understand student perspectives, particularly from remote contexts, about their engagement and success towards completion in higher education. Based on a qualitative research design situating Indigenist/interpretive research within a critical realism metatheory, we present findings from the study, based in the Kimberley region of Western Australia, and unpack implications for higher education provision in remote contexts. The findings point to the unique challenges faced by students who live in the Kimberley—and perhaps in other remote locations around Australia. In order to meet these needs, we suggest that tertiary education providers must tailor provision to ensure that engagement with Aboriginal students is relational and culturally safe.