bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulation and Evaluation of Pulsatile drug delivery of Albuterol sulphate and Theophylline drugs using modified Pulsincap technology
Authors: Reddy G. Govinda , Jat Rakesh Kumar , Manjanna K M
Published: February 2024

Albuterol Sulphate and Theophylline are used as anti-asthma agents. The objective of the present investigation was to design develop and evaluate a modified pulsincap drug delivery system of Albuterol Sulphate and Theophylline for the treatment of Asthma. The body of capsule was made insoluble with water by cross linking with formaldehyde. This modified capsule was completely filled with drug with polymer such as HPMCK15M, HPMC K 100M, PVPK-30 to expel the drug after predetermined lag time. A hydrogel plug was inserted in the body of a capsule to obtain desired drug release after a lag time for chronotherapy of asthma. Untreated capsule was attached to the treated body and was released. The drug was exerted to precompression parameter such as Angle of repose, Bulk density, Tapped density, Car’s index Hassner’s ratio. These capsules were subjected to further post formulation studies such as weight variation, drug content, invitro dissolution studies separately. The pre and post formulation parameters were found to be within permissible limit. The mere compatibility of drug, polymer and excipients were determined by Fourier transform infrared analysis (FTIR) and UV-Visible spectroscopy (UV). The results showed that drug was completely compatible with polymer and excipients. In vitro dissolution were carried out by using pH 6 .8 and pH 7.4 buffers. Based on the result obtained F5 Formulation shows good dissolution profile. Higuchi, Hixson crowell. Koresmeyer peppas to evaluate the kinetics and drug release. The drug release follows first order kinetics and the mechanism was found to be NON FICKS DIFFUSION.

Keywords: Albuterol Sulphate, Theophylline, modified pulsincap drug delivery system, FTIR, Dissolution
Solid dispersion: application and limitations
Authors: Mohammed Ebtissam Ameer , Alfahad Mohanad , Qazzaz Mohannad E
Published: February 2024

Solubility and dissolution rate are essential factors in the bioavailability of a drug. The drug must be well-soluble in water to have good bioavailability. Solid dispersion is among the most widely used and effective methods for increasing solubility and releasing inadequately water-soluble medications. Solid dispersion requires the choice of a suitable carrier for the right active pharmaceutical ingredients and the proper techniques for preparing solid dispersions. The reliable dispersion system is designed in various ways to achieve the goal and avoid the accompanying obstacles.

Keywords: solid dispersion, solubility, solvent evaporation, lyophilization, generation, methods
Effects of Intravenous Lidocaine as an Analgesic Adjuvant in Oncological Pain
Authors: Villar-Herrera Viviana Andrea , Juárez-Lemus Angel Manuel , Guillén-Núñez María del Rocío , Castillo-Ramirez Lizeth , Gutierrea-Herrera Gian Marco
Published: February 2024

Objectives: To verify that intravenous lidocaine is effective as an adjuvant analgesic in pain for hospitalized cancer patients at the National Institute of Cancerology, Mexico. Methods: Clinical records of patients hospitalized at the National Institute of Cancerology who received intravenous lidocaine infusion as an adjuvant to pain during the 4-year period from November 1, 2019, to October 31, 2023, were reviewed. Patients who met inclusion and exclusion criteria were included. A statistically significant measure was defined as a decrease equal to or greater than 4 points in the NRS value after lidocaine administration.

Results: A total of 179 patients were included; 46.4% were men, and 53.6% were women. The most common painful syndrome was somatic (54%). Patients with neuropathic pain received a higher lidocaine dose (mg/kg/hr) of 1.9 ± 0.79. Regarding adverse effects, 1.7% of patients experienced them. It was established that a reduction of 4 points with respect to the previous value on the numeric rating scale (NRS) would be considered statistically significant. A statistically significant association was found between patients under 38 years old and a higher risk of not achieving the objective (p 0.05, CI 0.95–1 OR 0.9). Patients who received lidocaine infusions for less than 4.63 days also had a risk of not reaching the goal (p 0.02, CI 0.7–0.9, OR 0.8).

Conclusions: This study demonstrated that the analgesic adjuvant use of intravenous lidocaine infusion is an effective and well-tolerated analgesic intervention for oncology patients.

Keywords: lidocaine, Neuropathic Pain, Somatic Pain, Visceral Pain, numeric rating scale.
Effectiveness of subcutaneous morphine in the treatment of pain crises in cancer patients
Authors: Aguilera-Elizalde Blanca Betsabe , Guillén-Núñez María del Rocío , Juárez-Lemus Angel Manuel , Plancarte-Sánchez Ricardo , Hernández-Rodríguez Daniela , González-Vega Oliver Humberto
Published: February 2024

Objective: The purpose of this study was to evaluate the efficacy of subcutaneous morphine for managing pain crises resulting from various causes in cancer patients attended by the Pain Clinic in the immediate care area of the National Cancer Institute in Mexico City.

Materials and Methods: This study was analytical, observational, retrospective, and descriptive. The oncology patients treated in the immediate care area for pain crises between August 1, 2020, and July 1, 2023, made up our study population. We documented the management of pain crises for patients who needed subcutaneous morphine treatment.

Results: Considering a reduction in Numeric Rating Scale (NRS) score >30% as effective and a reduction <30% as ineffective, 566 patients didn’t require an additional dose of subcutaneous morphine to control the pain crisis; 11 patients reported a decrease of <30%. A total of 24 patients needed a second rescue. Among this group, only 5 responded well to the second morphine rescue; in the remaining 19 patients, the rescue was deemed ineffective if the NRS decreased by at least 30%. Only 5 individuals experienced moderate pain, and only one patient reported severe pain. The variables were compared using the non-parametric Mann-Whitney U test with significance <0.05. Consequently, it may be said that there is a statistically significant difference between the first and subsequent NRS values obtained.

Conclusion: For oncology patients treated by the Pain Clinic in the immediate care section of the National Cancer Institute in Mexico City, subcutaneous morphine is beneficial in managing pain crises of different origins.

Keywords: Morphine, Subcutaneous Pain crises, Efficacy, Numeric rating scale
A Pharmacognostic, phytochemical and pharmacological review of Pterocarpus marsupium: Comprehensive Review
Authors: Deshpande Mangirish Narendra , Dighe Pearl , Nagare Sujit
Published: February 2024

Research in herbal drug is need of the hour to find definite lead for discovery of medicine from plant source. Many traditional medicinal plants are under screening to scientifically reinforce their traditional claims. Pterocarpus marsupium is time tested important source of herbal medicine which has been used extensively for treatment of diabetes mellitus. It has also exhibited antimicrobial activity, analgesic activity, anticataract activity. Acute toxicity test determines safe dose of the Pterocarpus marsupium. Various extraction methods such as Infusion, Decoction, Maceration, Percolation and Hot Water Extraction s employed for efficient extraction of phytoconstituents. Primary phytoconstituents present in the bark comprises of liquiritigenin, isoliquiritigenin, pterosupin, epicatechin, and pterostilbene. Current review is carried out to study pharmacognstic, phytochemical and pharmacological activity of the drug, which can be useful for researcher to provide synoptic overview about Pterocarpus marsupium  

Keywords: Pterocarpus marsupium, Review, Fabaceae, Indian kino, Asan
Screening for Food Insecurity: A Curriculum for Medical Students
Authors: Jarris Yumi Shitama , Chang Heidi , Kureshi Sarah , Mishori Ranit , Kaljee Linda , Hunting John , Saint Laurent May-Lorie , Chen H. Carrie
Published: February 2024

Introduction: Food insecurity (FI) is defined as a lack of access to enough food for an active, healthy life. We sought to determine how a longitudinal FI screening curriculum impacts medical students’ knowledge, attitudes, and behavior in screening for FI.
Methods: This was a prospective, single-institution study. The curriculum consisted of three components completed over 3 years. We administered a survey to the intervention cohort before and after the curriculum and analyzed their written reflections. We also evaluated whether students screened for FI during an objective structured clinical exam (OSCE) and compared their performance to a control cohort, which did not receive the curriculum.
Results: Preintervention, students felt screening for FI was important for physicians to do with their patients, but most felt uncomfortable addressing it in clinical settings. Postintervention, there was a statistically significant increase in mean scores for knowledge questions (45.24% vs 74.74%, P<.001, pre- and postintervention, respectively). Students also felt more confident in their abilities to screen and follow up about FI. Additionally, compared to the control cohort, the intervention cohort screened for FI more often during their OSCE (28.21% vs 10.71%, P<.001).
Conclusion: A longitudinal curriculum using minimal curricular time can improve students’ knowledge, attitudes, and behavior when screening for FI. Students who received the curriculum were more likely to recognize the need for and perform FI screening. Based on these findings, we anticipate that the curriculum will increase the likelihood of students identifying, screening for, and intervening in cases of FI in future clinical encounters.
Visión actual del bitcoin desde la perspectiva de los inversionistas
Authors: Lopez Marin Jonathan Roberto , Paz Gómez Carlos Alberto , Hernández Romero Gladys
Published: February 2024

In recent months, the bitcoin cryptocurrency has presented constant variations in its price quotation, which has created the need to evaluate the impact generated by volatility on investors who operate with this cryptocurrency as a forecast of the relationship and level of satisfaction in the future. This article describes the analysis using a documentary methodology through which the current vision of bitcoin from the point of view of investors is carried out in order to obtain results that allow to know the situation of this cryptocurrency in relation to the volatility it generates and thus show the level of confidence that is had through the use of it. In this way, when analyzing the results, it was shown that the confidence has been variable in such a way that significant drops have been obtained with respect to the market quotation level of said crypto-asset.
Comparación de habilidades básicas y avanzadas de navegación, de la ciudadanía digital, en el proceso de enseñanza – aprendizaje de la filosofía
Authors: Giraldo Ramírez Luz Otilia , Gutiérrez Oquendo Henry
Published: February 2024

This article was approached in a general way in the basic concepts of citizenship, until reaching the digital citizenship on which we focus our research, more specifically in the teaching-learning process of philosophy. Likewise, through information from reliable sources, such as the Digital Economy and Society Index (DESI), we extracted data bases from the last 6 years, which allowed us to verify trends on the basic and advanced skills of the user in the use of the Internet; on the other hand, the Cybersecurity page allowed us to analyze the vulnerabilities suffered by the digital citizen when navigating in cyberspace.

Finally, we interpreted the results, and subsequently presented them coherently in tables and graphs in which a growth of basic navigation skills was evidenced, but which, when comparing data, revealed a very low level compared to the advanced skills that every citizen should have, with national, multilateral, post-national, multicultural or differentiated, cosmopolitan or global, gender and inclusion, youth, spatial or digital nationalities, in the process of education mediated by ICTs.
Auditoria fiscal: impacto en las obligaciones fiscales de los contribuyentes
Authors: Campos Rodríguez Kimberlyn Selena , Guzmán Fernández Candelaria , Martínez Prats Germán , Silva Hernández Francisca
Published: February 2024

The audit is an essential part of accounting since it allows to identify, verify that all the financial information made by the company is correct, with the application of the audit it helps to have a reasonable security about the operations of the taxpayers this in order to detect errors and know if they comply with the tax obligations to which they are subject, so its application is of great help both to the tax authorities and to the taxpayers themselves. The objective of this article is to describe how tax auditing has an impact on the obligations to which taxpayers are bound, so the application of an audit in tax areas allows an efficient verification in the operations carried out by taxpayers, so its application is of utmost importance so that they efficiently comply with their obligations.
Crímenes de guerra; Tribunal Militar Internacional: Juicios de Núremberg
Authors: García Becerril Gabriel
Published: February 2024

The Nuremberg Trials were a set of judicial processes conducted after World War II to prosecute Nazi leaders and other individuals responsible for war crimes, crimes against humanity, and genocide. These trials took place in the city of Nuremberg, Germany, between 1945 and 1946. The trials were set up by the Allies (the United States, the United Kingdom, France and the Soviet Union) with the aim of holding Nazi leaders accountable for their atrocities during the war, including the Holocaust and other crimes committed against millions of people. The aim of this research is to describe through a descriptive-qualitative mythology the impact that these trials had after the Second World War.
La relación de la producción y liquidez de una empresa con la selección y contratación del personal
Authors: Gómez Castellanos Jorge , Suárez Jiménez Rosario Del Carmen , García Álvarez Aída Dinorah
Published: February 2024

When carrying out a recruitment or selection process, it is important to take into account a series of factors that, in some situations, may develop incorrectly, with unfavorable effects that end up affecting the company.
The company uses its employees more because it wants them to contribute more. It should be noted that in the recruitment and selection of personnel, techniques such as training, competency assessment, motivation, flexibility or adaptation to change were mentioned. The company was evaluated, and the increase in production and liquidity will be based on the use of seeking or not the necessary vacancy for other areas. Since the data was collected using a specific and defined instrument, the focus of this study is quantitative. As it seeks to identify the causes of facts and physical or social phenomena, the investigation has an explanatory scope. It should be noted that the main objective of this research is to determine the problems that have occurred in the organization responsible for the commercialization of food products with the selection and hiring of personnel. And based on the results, it can be concluded that the biggest problems are: The lack of a clear understanding of the company's need for human talent (31%). Absence of key personnel during recruitment interviews (19%), and 56% of surveyed employees at the company believe that problems that have arisen during selection and recruitment processes have led to increased staff turnover, which This makes it difficult to define the needs of the company.
Impacto en la economía de actividades ilícitas en los últimos años y su transformación en México
Authors: Sánchez López Perla Rubí , Vidal Fócil Ana Bertha
Published: February 2024

Este artículo tiene como objetivo analizar el impacto de la economía de actividades ilícitas en los últimos tres años en México, con el fin de identificar los factores que han contribuido en su transformación negativa y proponer medidas efectivas para combatirlas y prevenirlas en el futuro. El estudio abarca la evolución que han tenido las actividades ilícitas como el narcotráfico y la corrupción que representa una amenaza para el desarrollo económico nacional e internacional y que destruye la confianza en los ciudadanos, revelando que varios factores han contribuido a esta transformación negativa. En primer lugar, se destaca el crecimiento de organizaciones criminales y su capacidad para diversificar sus actividades, incluyendo el tráfico de drogas, la trata de personas, la extorsión y el lavado de dinero. Estas actividades generan grandes ganancias y socavan la estabilidad económica y social del país. Dando como resultado la identificación de la corrupción generalizada como un factor clave que facilita la operación de las actividades ilícitas. La metodología utilizada fue de forma descriptiva, explicativa y de observación ya que se investigó en distintas fuentes de información como noticias, informes y páginas web bajo la técnica de un diseño mixto. Por lo tanto, se concluye que es de vital importancia conocer la situación en la que se encuentra la economía del país.
Desafíos de los agricultores para la exportación de sus productos: una revisión sistemática de literatura
Authors: Castillo Chan Francisco Javier
Published: February 2024

En el presente estudio se analiza y sintetizar la documentación científica existente sobre aquellos estudios empíricos asociados a los desafíos arancelarios y no arancelarias con relación a la exportación agrícola a nivel internacional, dado las problemáticas que estás ocasionan a los agricultores para participar en los mercados extranjeros. El estudio se limita a la literatura encontrada entre 2013 al 2023 y partiendo del método PRISMA  (Preferred Reporting Items for Systematic reviews and Meta-Analyses) para estudios de Revisión Sistemática de Literatura (RSL), usando las bases de datos de Scopus, Web of Science, Springer y SciELO. Dentro de los hallazgo encontrados se encuentra un vacío en estudios cualitativos ligados a las barreras no arancelarias, la falta de estudios realizados en México y la carencia del factor de desconocimiento cultura como detonante para la colocación exitosa en otros mercados.
Perspectiva sistémica de la generación de residuos y pérdidas de alimentos en Colombia
Authors: Ibarra Vega Danny
Published: February 2024

This work presents an advance in the systemic representation of the generation of waste and food losses in a food production system of agricultural origin in the context of Colombian food chains. For this, the phases of the production system were identified, and after that, some causes associated with food loss were identified. Once the system was understood in a linear manner, it was possible to interconnect the entire system from the systemic perspective, using a causal diagram with feedback structures. This made it evident that the problem must be addressed with tools that allow studying complex systems, since the food production system has feedbacks, interconnections and delays that cannot be demonstrated separately from each other. This is a first advance in order to understand food production chains in a systemic and complex way, in order to mitigate the generation of waste and food losses in Colombia.
Toma de decisiones en cadenas de suministro globales resilientes: Una aproximación teórica
Authors: Barragán Moreno Gabriel Ernesto , Rocha Medina Linda Bibiana
Published: February 2024

The strong competition of global supply chains in international markets requires a quick response from the decision maker that allows the resumption of interrupted operations in the presence of disruptive events. The purpose of this paper is to establish the origin of the decisions that characterize the resilient supply chains together with the tools proposed through academic and investigative efforts that allow supporting decision-making.
 
The authors carried out a review of scientific articles published in the last 12 years, of which 67 texts related to resilience and risk management in the global supply chain were analyzed. The result of this analysis allowed to identify: i) the limited academic progress in the development of tools that support post-disruption decision-making, ii) developments to support structured and unstructured decision-making, iii) implementation initiatives intelligent systems to support decisions in the resilient supply chain, and iv) application of highly efficient algorithms developed to solve models that allow structured decision making. The results of this work are of great value to the academic and scientific community that suggests developments in the area and its concerns is the assurance of the normal operation of the global supply chains.​
Do equity investors’ socio economic identities have association with their perceived risk? Evidence from the emerging market
Authors: Borah Navajit , Yarso Awungshi
Published: February 2024

Equity investors’ decision-making efficacy can be enhanced by enlarging the understanding horizon on the matrix between their socio-economic identities and risk perception (Su et al., 2022; Shah et al., 2020). This work attempts to examine the relationship between equity investors’ socio-economic identities and their perceived risk in Assam, a state in North-East India. The study uses a structured instrument that undergoes a pretest to assess its content validity using Lawshe’s (1975) content validity ratio (CVR) method. The study applied Cronbach’s alpha to test the instrument reliability of 15 items which stood at 0.749. The study employed a comprehensive sample size of 408 retail investors, picked up using a systematic random sampling technique, hailing from the cities of Guwahati and Silchar in the state of Assam (response rate: 69.54 percent). The findings of the study indicated that there is a substantial inverse relationship between age and income, and equity investors’ total risk perception. However, the effect of investing experience on risk perception was found to be insignificant. Previous research has also reported similar findings (Bairagi & Chakraborty, 2018). Despite the limitations inherent in the study, such as the sample size being confined to a certain geographic location or demographic group, it is anticipated that this research will make a valuable contribution to the current body of literature on investor risk behaviour. Additionally, it is intended to have practical implications for brokerage houses, market analysts, and regulators within the financial industry.
Assessment of Seasonality in Eosinophilic Dermatosis of Haematological Malignancy
Authors: Brun Aurore , Ysebaert Loic , Oberic Lucie , Lamant Laurence , Sibaud Vincent
Published: February 2024

Abstract is missing (Short communication)
Vergleich unterschiedlicher Verfahren zur Baumstreifenpflege im Apfelanbau
Authors: Thalheimer Martin , Martinelli Julia , Kelderer Markus , Lardschneider Ewald , Ebner Ines
Published: February 2024

Die Baumstreifenpflege ist eine der zentralen Pflegemaßnahmen im intensiven Apfelanbau. Die Pflege des Baumstreifens ist unerlässlich für eine wirtschaftlich erfolgreiche Betriebsführung. Das Ziel der Baumstreifenpflege liegt vornehmlich darin, die Konkurrenz um Wasser und Nährstoffe zwischen den Obstbäumen und der sich ebenfalls am Baumstreifen entwickelnden spontanen Vegetation möglichst gering zu halten. Zu diesem Zweck hat sich im Laufe der letzten Jahrzehnte im konventionellen Obstbau allgemein der Einsatz von chemischen Herbiziden etabliert. Die zunehmend kritische Bewertung des Herbizideinsatzes in der Öffentlichkeit hat die Anwendung von mechanischen Verfahren zur Baumstreifenpflege verstärkt in den Vordergrund rücken lassen. Im vorliegenden Versuch wurde der Einsatz einiger mechanischer Geräte zur Baumstreifenpflege mit der herkömmlichen Herbizidanwendung hinsichtlich des Wuchs- und Ertragsverhaltens von Apfelbäumen, aber auch des erforderlichen Arbeitsaufwandes verglichen. Dazu wurde eine mehrjährige Studie auf Apfelanlagen verschiedener Sorten durchgeführt, sowohl bei Jungpflanzungen als auch bei Ertragsanlagen. Die Ergebnisse weisen keine wesentlichen Unterschiede zwischen den Verfahren bezüglich der Produktionsleistung der Ertragsanlagen auf, während bei den Junganlagen die chemische Baumstreifenbehandlung teilweise eine bessere Wuchsstärke und eine höhere Ertragsleistung der Bäume bewirkte. Alle Varianten der mechanischen Baumstreifenpflege erforderten jedoch einen deutlich höheren Arbeitsaufwand als die chemische Baumstreifenpflege.
Spatial geometric thinking and its articulation with the visualization and manipulation of objects in 3D
Authors: Lavicza Zsolt , Abar Celina A. A. Pereira , Tejera Mathias
Published: February 2024

This paper aims to build a conceptual framework that addresses spatial geometric thinking and the respective visualization skills required at different levels of the schooling process. Studies indicate that spatial geometric sills are essential for scientific thinking. It encompasses a set of cognitive processes through which humans can construct and manipulate mental representations of objects in space and is a skill directed towards understanding objects and their relations in the 2D and 3D worlds.  The use of these spatial reasoning skills involves drawing, manipulating, and explaining objects and their relationships and should be developed from the first years of schooling. Based on this theoretical context, partial research results on surface representations that can be manipulated in three dimensions (3D) and obtained through GeoGebra will be presented in this paper. The underlying theory was Duval's Theory of Registers of Semiotic Representation, which allowed the analysis of activities developed by graduate students in Mathematics Education by observing and physically manipulating such representations to obtain the respective graphic and algebraic records. The conceptual framework constructed and presented in this article contributed to identifying other skills required in this study for the development of spatial geometric thinking.
Prevention of bullying among teenagers by methods of social theater
Authors: Буравлева Наталья Анатольевна , Серяков Виталий Владимирович
Published: February 2024

В последние годы ситуации буллинга среди подростков происходят все чаще. Они негативно влияют на эмоциональное состояние обучающихся, развитие личности, могут приводить к трагическим случаям с непоправимыми последствиями. Одной из задач педагогических коллективов образовательных учреждений является предупреждение прецедентов проявления жестокости среди подростков, профилактика буллинга. К эффективным методам профилактики буллинга в школе можно отнести социальный театр, который выполняет широкий спектр функций по отношению к его участникам: информационно-образовательную, познавательную, развивающую, социально-коммуникативную. Профилактика буллинга посредством социального театра направлена на осмысление темы буллинга, выработку негативного к нему отношения, осознание степени проблемы и способов ее решения.

In recent years, we have seen an increase in bullying situations among teenagers. According to the World Report on Violence against Children, one in ten schoolchildren in the world is exposed to violence in an educational environment, and this figure is increasing every year. Bullying negatively affects the emotional state of children, personality development, and can lead to tragic cases. The task of the teaching staff of educational institutions is to prevent precedents of cruelty among adolescents, to prevent bullying. Effective methods of bullying prevention at school include social theater. Social theater involves a group form and step-by-step work: preparing a performance on the topic of bullying and showing it to the audience with subsequent discussion. Through social theater, it is possible to simulate various situations that reproduce the conflict situation of adolescents with the search for a way out of it. The peculiarity of the social theater is the involvement of the audience in the ongoing process, their participation in the discussion, the opportunity to switch places with the performers of the roles, in practice to demonstrate the proposed solutions to the problem. Theatrical practices contribute to the social activation of adolescents, the acquisition of communication skills, and the testing of social roles through dramatization and improvisation. Social theater is an effective and gentle method when dealing with bullying, age and existential crises, interpersonal and intrapersonal problems. Social theater performs a wide range of functions in relation to participants and viewers: informational, educational, cognitive, developmental, social and communicative. Bullying prevention through social theater is aimed at understanding the topic of bullying, developing a negative attitude towards it, realizing the extent of the problem and ways to solve it.
Peculiarities of using the professionally oriented graphic tasks for railway students
Authors: Чабан Елена Анатольевна , Стрикалова Наталия Владимировна
Published: February 2024

Подготовка инженерных кадров, обладающих определенным набором профессиональных компетенций, позволяющих использовать современные достижения науки и уровень цифровых технологий в области железнодорожного транспорта, на сегодняшний день имеет огромное значение. Сквозной нитью проходит через общепрофессиональные и профессиональные компетенции формирование так называемой графической компетенции. Рассмотрены возможности и преимущества использования профессионально адаптированных учебных графических задач в учебном процессе для студентов строительно-железнодорожных специальностей, способствующих формированию графической компетенции, а также процессу профессионального становления обучающегося. Представлены примеры профессионально адаптированных учебных графических задач для строительно-железнодорожных специальностей.

The training of the engineering personnel with a certain set of professional competencies that allow the use of modern scientific achievements and the level of digital technologies in the field of railway transport is of great importance today. The formation of the socalled graphic competency is one of the main general professional and professional competencies to be developed. The possibilities and advantages of the professionally adapted educational graphic tasks for the students of the railway construction specialty in the educational process, which contribute to the formation of the graphic competence, as well as the process of professional development of students, are considered. The examples of the professionally adapted educational graphic tasks for the railway construction specialty are presented.
Longitudinal studies of language errors based on a German-language learner corpus
Authors: Котюрова Ирина Аврамовна , Сафонов Георгий Романович
Published: February 2024

В эпоху цифровизации и активного распространения корпусных технологий в лингвистическом образовании специалисты в области лингводидактики постоянно открывают все новые возможности в работе с большими данными. Одним из относительно новых явлений в российском образовании является сбор корпусов ученических текстов на иностранном языке. Их возможности для лингводидактических исследований зависят прежде всего от продолжительности сбора данных и от разметки, которую содержит тот или иной корпус. В статье речь идет о корпусе немецко-язычных студенческих текстов Петрозаводского аннотированного корпуса текстов и лонгитюдном исследовании типов лингвистических ошибок, допускаемых студентами на всем протяжении изучения немецкого языка в течение 5 лет. Результатом исследования стала статистика по 90 классам ошибок, поделенных на семь основных групп, и динамика этой статистики на протяжении 5 лет обучения немецкому языку. Сравнение наиболее частотных ошибок на первом и пятом курсах показывает, что к темам, которые на протяжении всех годов обучения вызывают наибольшие проблемы у студентов, относятся выбор лексемы, орфография, пропуски, пунктуация и обратный порядок слов. Уходят к концу обучения в вузе проблемы с неопределенным артиклем, склонением прилагательных и существительных, образованием множественного числа и родом существительных, уступая место другим проблемам, таким как лишние элементы, логика, порядок слов в придаточных предложениях и стилистические ошибки.

In the age of digitalization and the active spread of corpus technologies in linguistic education, linguodidactics specialists are constantly discovering new opportunities in working with big data. One relatively new phenomenon in Russian education is the collection of corpora of student texts in a foreign language. It’s possibilities for linguodidactical research depend primarily on the duration of the data collection and on the markup that corpus contains. The article focuses on the corpus of German-language student texts PACT (Petrozavodsk annotated corpus of texts) and longitudinal research of types of linguistic mistakes made by students throughout the study of the German language for 5 years. The result of the research is statistics for 90 classes of errors, divided into 7 major groups – grammar, vocabulary, orthography, punctuation, discourse, omissions and superfluous elements – and the dynamics of these statistics over the 5 years of German language study. Comparison of the most frequent errors made by 1st and 5th year students respectively shows that subjects causing the most problems for students during all years of study are lexeme selection, orthography, omissions in text, punctuation and reverse word order. At the end of study problems with indefinite articles, adjective and noun declension, formation of plural form and gender of nouns are giving way to other issues such as superfluous elements in text, logic, word order in subordinate sentences and stylistic errors.
Optimization of didactic communication of a physical education and sports teacher in the context of digital transformation of education
Authors: Макеева Вера Степановна , Кулин Алексей Андреевич
Published: February 2024

Рассматривается разработка технологии оптимизации ресурсной составляющей профессионально-личностного развития специалиста по физическому воспитанию, которая актуализировалась в связи с трендами цифровизации образовательной системы. Дана характеристика дидактической коммуникации в виде передачи и приема информации между субъектами учебно-тренировочного процесса, усвоения знаний, двигательных умений, навыков и формирования здорового образа жизни. Раскрыта специфика коммуникации на занятиях физической культурой и спортом в условиях цифровой трансформации, приносящая изменения у субъектов обучения в личностном, профессионально-групповом и социокультурном уровнях. Со стороны преподавателя физической культуры это проявляется в постоянном обновлении своих знаний, отслеживании изменений в образовательных запросах студентов во времени, овладении навыками убеждения, демонстрации своего отношения к здоровому образу жизни и двигательной активности как фактору эффективного жизнеобеспечения современного члена общества. Описаны эффективные инструменты онлайн- и офлайн-взаимодействия, дидактическое наполнение учебно-тренировочного процесса, способствующие повышению уровня физического развития и физической подготовленности, отношения студентов к физической активности и интереса к занятиям как компонента культурного развития студентов.

The issue of developing a technology for optimizing the resource component of the professional and personal development of a specialist in physical education, which have been updated in connection with digitalization trends in the educational system, is considered. The characteristic of didactic communication in the form of transmission and reception of information between the subjects of the educational and training process, the characteristics of the assimilation of knowledge, motor skills, skills and the formation of a healthy lifestyle are given. The specificity of communication in physical culture and sports classes in the conditions of digital transformation is revealed, which brings changes in the subjects of education at the personal, professional-group and socio-cultural levels. On the part of the teacher of physical culture, this is manifested in the constant updating of their knowledge, tracking changes in the educational needs of students over time, mastering the skills of persuasion, demonstrating their attitude to a healthy lifestyle and physical activity as a factor in the effective life support of a modern member of society. The effective tools of online and offline interaction, didactic content of the educational and training process, which contribute to increasing the level of physical development and physical fitness, the attitude of students to physical activity and interest in classes as a component of the cultural development of students, are described.
A metrological reflection on uncertainty about the use of maps instead of global parameters
Authors: Pavese Franco
Published: February 2024

Recently, there has been an abnormal use of global parameters not only in economical fields, but also in scientific ones, like meteorology and climate. They are supposed to convey in a clear way the most important significance in the changes of numerical parameters. However, synthetic global parameters may miss the complexity of the issue that they are intended to qualify, so that trivializing their meaning. The paper discusses the fact that this effect is more than trivialization because the evaluation of a map, e.g. an Earth map, which is often contrasted, is less sensitive to the uncertainty that shall always be associated with any type of information, namely the numerical one, when the uncertainty evaluation is associated with the parameter value. In most cases, and especially when the map shows a great variety of situations, a visual examination allows, even to a scientist, different methods for a more reliable evaluation. General cases are reported to exemplify the above statement.
Thyroid dysfunction in women with metabolic syndrome and type 2 diabetes
Authors: Pasyechko N.V. , Kulchinska V.M. , Naumova L.V.
Published: February 2024

The most common endocrinopathies are pathology of the thyroid gland and diabetes. Thyroid hormones affect glucose metabolism in diabetes, just as diabetes affects thyroid functionObjective. The aim of this study was to explore the relationship between components of the metabolic syndrome, thyroid function, and IL-6 levels in patients with type 2 diabetes.Material and methods. We examined 65 women with type 2 diabetes (average age – (45±0.88) years), and 30 practically healthy women of the control group (average age – (44.14 ± 0.74) years). All patients underwent clinical, anthropometric and biochemical examination. The level of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, antibodies to thyroperoxidase, glucose, glycated hemoglobin, HOMA index, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol were determined. The research was carried out on a Cobas 6000 biochemical analyzer using Roche reagents. In all patients, the level of IL-6 was determined by the method of solid-phase enzyme immunoassay.Results. Among all examined, 19 (29.2%) women were found to have subclinical hypothyroidism on the background of an autoimmune process, their average TSH level was within 4.85±0.21 mU/l, ATPO –572.89±12.29 IU /ml, 9 (13.8%) had hypothyroidism on the background of an autoimmune process, their average TSH level was within 10.10±0.19 mU/l, ATPO –823.76±11.91 IU/ml, and 12 (18.4%) people were carriers of antithyroid antibodies, their average TSH level was within 1.76±0.26 mU/l, ATPO –368.81±14.26 IU/ml. It was found that the average level of IL-6 in patients with type 2 diabetes and AIT was 21.76±0.19 pg/ml, in patients with type 2 diabetes, AIT and SCH – 24.85±0.21 pg/ml, in patients with type 2 diabetes, AIT and HT – 27.43±0.24 pg/ml, patients with type 2 diabetes with normal thyroid function – 18.45±0.19 pg/ml, control group patients - 5,74±1.12 pg/ml. Conclusions. In patients with autoimmune thyroiditis and type 2 diabetes, a relationship of medium strength was found between IL-6 and OT (r=0.32; p<0.05), IL-6 and BMI (r=0.34; p< 0.05), IL-6 and HbA1c (r=0.31; p<0.05), IL-6 and HOMA-IR (r=0.35; p<0.05), IL-6 and TC ( r=0.31; p<0.05) weak correlation between IL-6 and LDL (r=0.21; p<0.05), IL-6 and TG (r=0.18; p <0.05), strong correlation relationship between IL-6 and ATPO (r=0.78; p<0.05), IL 6 and TSH (r=0.62; p<0.05).
Digitalization of ECG in optimization of diagnostics of acute and chronic coronary syndromes
Authors: Tashchuk V.K. , Malinevska-Biliichuk O.V.
Published: February 2024

The aim is to study the additional diagnostic possibilities of indicators obtained by digitalization of ECG in patients with ST-elevation myocardial infarction (STEMI) and stable angina (SA).Material and methods. 135 patients were examined, who were divided into groups depending on the diagnosis: 45 people with STEMI and 90 patients with SA. According to the value of the first derivative of the T wave - the maximum speed ratio (MSR) indicator, patients with STEMI were divided into two groups: group I included 25 people with MSR <0.66, group II - 20 patients with MSR ≥0.66. Patients with SA were also distinguished depending on MSR: group A included 41 patients with MSR <0.87 and group B - 49 patients with MSR ≥0.87. The results of echocardiography, Holter ECG monitoring, coronary ventriculography and digitalization of ECG based on the «Smart-ECG» medical software were evaluated.Results. In the STEMI group, significantly lower MSR values of ischemic zone were noted, compared to the group of patients with SA (0.65±0.02, Δ –25.29%, p<0.001), higher STH values in ischemic zone (0.76±0.04 mm, Δ +58.33%, p<0.001), lower left ventricular ejection fraction (LVEF) (51.96±1.21 %, Δ -9.82%, p<0.001), longer ischemia (919.00 (133, 00; 1310.00) min, Δ +3729.17%, p<0.001), lower standart deviation values of N-N intervals (SDNN) (88.11±6.65 ms, Δ -20.88%, p=0.094). Individuals with SA and MSR <0.87 showed slightly higher values of MSR in lead V2, compared to the group of SA and MSR ≥0.87 (2.51±0.08, Δ +8.19%, p=0.058). In patients with STEMI and MSR <0.66 and with SA and MSR <0.87, compared to the group with STEMI and MSR ≥0.66 and with SA and MSR ≥0.87, lower LVEF were detected (respectively (52.00 (47.75; 55.00) %, Δ -10.34%, p=0.071) and (56.73±0.83%, Δ -3.14%, p=0.088).Conclusions. Primary changes in the repolarization phase, which are inherent for patients with STEMI and SA, cause a change in the speed parameters of the differentiated ECG – reducing of MSR (more intense for patients with STEMI), which indicates a pronounced electrical disbalance of the ischemic myocardium. Lower values of MSR result in worse clinical and functional characteristics of the myocardium for STEMI and SA and are associated with negative prognostic markers of ischemia.
Influence of androgen status on the quality of life in men suffering from coronary artery disease
Authors: Khaniukov O.O. , Bucharskyi O.V.
Published: February 2024

Introduction. Cardiovascular diseases, in particular, coronary artery disease, remain the leading cause of disability and mortality among the population in Ukraine and the world, which determines the urgency of finding new factors that can affect the quality of life of this population category. In particular, such factors may include androgenic status in men with coronary artery disease. Available literature data indicate a possible relationship between androgenic status and QOL in this population category, but further research is needed to study this issue in more detail.The purpose of the study: to determine the influence of androgen status on the quality of life in men suffering from coronary artery disease (CAD). Material and methods. 85 men with coronary artery disease aged 45-65 years participated in this prospective observational study. The selection of patients was carried out on the basis of the cardiology department. In addition to standard clinical and paraclinical examination methods, patients were assessed for their androgenic status by determining the level of total testosterone in the blood serum. When evaluating the quality of life level, a survey was conducted according to the WHOQOL-BREF questionnaire, which includes 4 sub-sections that determine respondents' satisfaction with their own physical and psychological health pit, environment and level of social interaction. After counting the points, a score from 4 to 20 was formed for each of the subdivisions. Then, statistical processing of the obtained results was carried out.Results and discussion. As a result of the study, a reliable positive correlation of medium strength was found between the level of testosterone and the satisfaction of the study participants with their own physical and psychological health, the Spearman rank correlation coefficient was 0.55 (p<0.05) and 0 .51 (p<0.05), respectively.Conclusion. It was concluded that a higher level of testosterone was associated with greater satisfaction with one's own physical and psychological health in men with coronary artery disease, which indicates the influence of androgen status on the quality of life in this category of patients.Prospects for further research. The obtained results indicate the need for further study of the relationship between androgen status and quality of life in men with coronary artery disease and the search for its possible mechanisms.
Peran Guru Bimbingan dan Konseling dalam Membantu Meningkatkan Mengelola Emosi Peserta Didik yang Orang Tuanya Broken Home
Authors: Mudaim Mudaim , Wibowo Agus , Meilani Putu Wina
Published: February 2024

In this study, the focus of research is directed at the role of guidance and counseling teachers in helping students improve emotional management. Based on the focus of the problem above, the formulation of the research problem is: How is the emotional management of students whose parents are broken homes? What is the role of BK teachers in helping to improve the ability to manage emotions in students whose parents are broken homes? This research method uses qualitative research with descriptive research type. The presence of researchers as research data collectors as well as analyze data. The instrument in this study used interview sheets, observations, and documentation. Data analysis used descriptive inductive data analysis. The results of this study concluded that: Management of students' emotions before the role and intervention of guidance and counseling teachers, the condition of emotional management was still less than optimal. This is marked by students who have not been able to overcome the volatile emotions within themselves, are less able to control emotions, still have negative thoughts, stress, and withdraw from association. The role of the guidance and counseling teacher in helping to improve the emotional management of students is that the guidance and counseling teacher always acts as a guide, counselor, friend, advisor, and motivator for students. Through this role, the emotional management of students slowly improves well.
Az (orvos)szakértői bizonyítás a büntetőeljárásban
Authors: Szilvássy Zoltán
Published: February 2024

Durch die Strafprozessordnung wurden die Regeln der Sachverständigenbeweisführung erheblich verändert, so z.B. Um einer Verfahrensverlängerung vorzubeugen, versucht sie, den Prozess der Sachverständigenbestellung und Gutachtenbegutachtung in einen sinnvollen Rahmen zu lenken, um eine wohlüberlegte und zeitnahe Entscheidung treffen zu können. Die Zeit, die seit Inkrafttreten des Gesetzes vergangen ist, ermöglicht es uns bereits, die Praxis der Strafverfolgung zu untersuchen. Ich glaube, dass die größte Veränderung mit der Regelung des Privatgutachtens einhergeht, die es dem Angeklagten und seinem Verteidiger ermöglicht, im Strafverfahren ähnliche Rechte zu haben, die sich auch aus dem Grundsatz der Waffengleichheit ergeben. Und all dies stärkt die Fairness des Verfahrens im Allgemeinen, was ein Garant für die Entstehung von Gerichtsurteilen sein kann, die auch der materiellen Wahrheit nahe kommen.