bluuebunny/crossref_metadata_2025 huggingface dataset:
Reliability of Fingertip Skin-surface Temperature and its Related Thermal Measures as Indices of Peripheral Perfusion in the Clinical Setting of the Operating Theatre
Authors: Akata T. , Kanna T. , Yoshino J. , Higashi M. , Fukui K. , Takahashi S.
Published: January 2019

During the perioperative period, evaluation of digital blood flow would be useful in early detection of decreased circulating volume, thermoregulatory responses or anaphylactoid reactions, and assessment of the effects of vasoactive agents. This study was designed to assess the reliability of fingertip temperature, core-fingertip temperature gradients and fingertip-forearm temperature gradients as indices of fingertip blood flow in the clinical setting of the operating theatre.

In 22 adult patients undergoing abdominal surgery with general anaesthesia, fingertip skin-surface temperature, forearm skin-surface temperature, and nasopharyngeal temperature were measured every five minutes during the surgery. Fingertip skin-surface blood flow was simultaneously estimated using laser Doppler flowmetry. These measurements were made in the same upper limb with an IV catheter (+IV group, n=11) or without an IV catheter (-IV group, n=11).

Fingertip blood flow, transformed to a logarithmic scale, significantly correlated with any of the three thermal measures in both the groups. Their rank order as an index of fingertip blood flow in the -IV group was forearm-fingertip temperature gradient (r=-0.86) > fingertip temperature (r=0.83) > nasopharyngeal-fingertip temperature gradient (r=-0.82), while that in the +IV group was nasopharyngeal-fingertip temperature gradient (r=-0.77) > fingertip temperature (r=0.71) > forearm-fingertip temperature gradient (r=-0.66). The relation of fingertip blood flow to each thermal measure in the -IV group was stronger (P<0.05) than that in the +IV group. In the clinical setting of the operating theatre, using the upper limb without IV catheters, fingertip skin-surface temperature, nasopharyngeal-fingertip temperature gradients, and forearm-fingertip temperature gradients are almost equally reliable measures of fingertip skin-surface blood flow.
Anaphylaxis with Associated Fibrinolysis, Reversed with Tranexamic Acid and Demonstrated by Thrombelastography
Authors: De Souza R. L. , Short T. , Warman G. R. , Maclennan N. , Young Y.
Published: January 2019

In the surgical setting, fibrinolysis can be a serious complication of anaphylaxis. We present four cases of anaphylaxis that were associated with fibrinolysis during anaesthesia, and the use of the thrombelastograph to demonstrate this haemostatic defect and its correction using tranexamic acid.
Preventing Pain on Injection of Propofol: A Comparison between Lignocaine Pre-treatment and Lignocaine Added to Propofol
Authors: Lee P. , Russell W. J.
Published: January 2019

A randomized double-blind study compared two methods of preventing the pain from injection of propofol, lignocaine pre-treatment followed by propofol and lignocaine added to propofol. One hundred patients received a 4 ml solution intravenously with a venous tourniquet for 1 minute, followed by propofol mixed with 2 ml of solution. Patients were divided into two treatment groups of 50 patients each: 4 ml 1% lignocaine pre-treatment followed by propofol and 2 ml saline, or 4 ml saline followed by propofol and 2 ml 2% lignocaine. Pain was assessed with a 100 mm visual analogue scale after induction and in recovery. The incidence of injection pain was 8% in the propofol mixed with lignocaine group, and 28% in the lignocaine pre-treatment group. This difference is statistically significant (P=0.017). For those patients who had pain, the mean pain score was 26.5 on induction for the propofol with lignocaine group (n=4), while the mean score was 44.4 for the pre-treatment group (n=13). The difference was not statistically significant (P=0.25). None of the propofol mixed with lignocaine group recalled pain, while 13 of the pre-treatment group did so. Lignocaine pre-treatment does not improve the immediate or the recalled comfort of patients during propofol induction when compared to lignocaine added to propofol. It is recommended that lignocaine should be added to propofol for induction rather than given before induction.
Adjustment of Anaesthesia Depth Using Bispectral Index Prolongs Seizure Duration in Electroconvulsive Therapy
Authors: Nishihara F. , Saito S.
Published: January 2019

Electroconvulsive therapy (ECT) under propofol anaesthesia induces relatively shorter seizures compared to barbiturate anaesthesia. Since significant correlation between seizure duration and bispectral index (BIS) value immediately before electrical stimulus has been reported among patients, adjustment of anaesthesia depth as determined by BIS may be effective in obtaining a longer seizure length. In the present study, we examined this hypothesis in those patients whose muscular seizure duration was less than 40s.

ECT was prescribed to 20 patients suffering from endogenous depression. General anaesthesia was induced with propofol 1 mg/kg. Succinylcholine chloride 1 mg/kg was then given. The efficacy of electrical stimulation was determined using a tourniquet technique, electromyogram, and electroencephalography. When a patient had a seizure less than 40s in their second ECT treatment, the subsequent treatment was modified such that the electrical stimulus was given after waiting for a higher BIS value (+10-20). Intensity of electrical stimulus and anaesthesia conditions were identical in the two treatments.

All 20 patients had longer seizures as determined by the electromyogram and/or electroencephalography when the stimulus was delivered at the higher BIS value. Seizure duration measured by muscle movement was 31±5s when the stimulus was delivered without waiting and 46±10s when delivered after waiting. There was a significant difference in seizure duration between the two treatments (P<0.01).

Waiting for a recovery in BIS value before electrical stimulation can prolong seizure duration.
An Evaluation of the Relative Efficacy of an Open Airway, an Oxygen Reservoir and Continuous Positive Airway Pressure 5 cmH2O on the Non-ventilated Lung
Authors: Slimani J. , Russell W. J. , Jurisevic C.
Published: January 2019

The aim of this study, during one-lung ventilation, was to evaluate if oxygenation could be improved by use of a simple oxygen reservoir or application of 5 cmH2O continuous positive airway pressure (CPAP) to the non-ventilated lung compared with an open airway. Twenty-three patients with lung malignancy, undergoing thoracotomy requiring at least 60 minutes of one-lung ventilation before lung lobe excision, were studied. After routine induction and establishment of one-lung ventilation, the three treatments were applied in turn to the same patient in a sequence selected randomly. The first treatment was repeated as a fourth treatment and these results of the repeated treatment averaged to minimize the effect of slow changes.

Arterial oxygenation was measured by an arterial blood gas 15 minutes after the application of each treatment. Twenty patients completed the study. Mean PaO2 (in mmHg) was 210.3 (SD 105.5) in the “OPEN” treatment, 186.0 (SD 109.2) in the “RESERVOIR” treatment, and 240.5 (SD 116.0) in the “CPAP” treatment. This overall difference was not quite significant (P=0.058, paired ANOVA), but comparison of the pairs showed that there was a significant better oxygenation only with the CPAP compared to the reservoir treatments (t=2.52, P=0.021). While the effect on the surgical field was not apparent in most patients, in one patient surgery was impeded during CPAP. Our results show that the use of a reservoir does not give oxygenation better than an open tube, and is less effective than the use of CPAP 5 cmH2O on the non-ventilated lung during one-lung ventilation.
Effect of Diclofenac Pretreatment on Pain during Propofol Injection
Authors: Mohta M. , Agarwal D. , Sethi A. K. , Sandhu K.
Published: January 2019

In a randomized, double-blind, controlled trial, 120 ASA 1 or 2 patients were allocated to receive diclofenac or normal saline as pretreatment to assess their effect on incidence and severity of pain during propofol injection. Diclofenac in two different doses, i.e. 25 mg and 15 mg, was tried for this purpose. The overall incidence of pain did not significantly differ among the groups, but the incidence of moderate to severe pain following propofol injection was significantly less in patients who received diclofenac 25 mg (P=0.0017) or 15 mg (P=0.0363) than in those who received saline. However, the diclofenac itself was associated with mild pain in some patients.
Withholding and Withdrawal of Therapy in New Zealand Intensive Care Units (ICUs): A Survey of Clinical Directors
Authors: Ho K. M. , Liang J.
Published: January 2019

Withdrawing and withholding life-support therapy in patients who are unlikely to survive despite treatment are common practices in intensive care units (ICUs). The literature suggests there is a large variation in practice between different ICUs in different parts of the world. We conducted a postal survey among all public ICUs in New Zealand to investigate the pattern of practice in withholding and withdrawal of therapy. Nineteen ICUs responded to this survey and they represented 74% of all the public ICU beds and 83% of the annual ICU admissions. The percentage of ICU admissions with therapy withdrawn or withheld was less than 10% in most ICUs. Only a small percentage (21%) of ICUs had a formal policy in withholding and withdrawal of therapy. The timing of making the decision to withhold or withdraw therapy was very variable. The patient and/or the family, the primary medical team consultant, two or more ICU consultants, and ICU nurses were usually involved in the decision making process. ICU nurses were more commonly involved in the decision making process in smaller ICUs (5 beds vs 10 beds, P=0.03). The patient's pre-ICU quality of life, medical comorbidities, predicted mortality, predicted post-ICU quality of life, and the family's wishes were important factors in deciding whether ICU therapy would be withheld or withdrawn. Hospice ward or the patient's home was the preferred place for palliative care in 32% of the responses.
Cost Calculation and Prediction in Adult Intensive Care: A Ground-up Utilization Study
Authors: Moran J. L. , Peisach A. R. , Solomon P. J. , Martin J.
Published: January 2019

The ability of various proxy cost measures, including therapeutic activity scores (TISS and Omega) and cumulative daily severity of illness scores, to predict individual ICU patient costs was assessed in a prospective “ground-up” utilization costing study over a six month period in 1991.

Daily activity (TISS and Omega scores) and utilization in consecutive admissions to three adult university associated ICUs was recorded by dedicated data collectors. Cost prediction used linear regression with determination (80%) and validation (20%) data sets. The cohort, 1333 patients, had a mean (SD) age 57.5 (19.4) years, (41% female) and admission APACHE III score of 58 (27). ICU length of stay and mortality were 3.9 (6.1) days and 17.6% respectively. Mean total TISS and Omega scores were 117 (157) and 72 (113) respectively. Mean patient costs per ICU episode (1991 ÄS) were $6801 ($10311), with median costs of $2534, range $106 to $95,602. Dominant cost fractions were nursing 43.3% and overheads 16.9%. Inflation adjusted year 2002 (mean) costs were $9343 ($ AUS). Total costs in survivors were predicted by Omega score, summed APACHE III score and ICU length of stay; determination R2, 0.91; validation 0.88. Omega was the preferred activity score. Without the Omega score, predictors were age, summed APACHE III score and ICU length of stay; determination R2, 0.73; validation 0.73. In non-survivors, predictors were age and ICU length of stay (plus interaction), and Omega score (determination R2, 0.97; validation 0.91).

Patient costs may be predicted by a combination of ICU activity indices and severity scores.
Sedation for Paediatric Stereotactic Radiosurgery: The Dexmedetomidine Experience
Authors: Fahy C. J. , Okumura M.
Published: January 2019

Dexmedetomidine is a potent a2 adrenergic agonist, with sedative and analgesic properties which may make it a suitable sedative agent for procedures on paediatric patients. A six-year-old boy required sedation for stereotactic radiosurgical ablation of an arteriovenous malformation on two occasions. Sedation with dexmedetomidine was planned, with increased dosage used on the second occasion. On both occasions dexmedetomidine was inadequate as a sole agent and required supplementation with other agents.
Pulmonary Arteriovenous Malformation Masquerading as Massive Pulmonary Thromboembolus
Authors: Mcgrath C.
Published: January 2019

We present a case of a 78-year-old male with hereditary haemorrhagic telangiectasia and severe hypoxia incorrectly diagnosed as pulmonary embolism following a false positive ventilation/perfusion scan. Anti-coagulation and thrombolysis was complicated by an upper gastro-intestinal haemorrhage. Pulmonary arteriovenous malformations resulted in a clinically significant right-left shunt and created an apparent perfusion defect evident upon radionuclide imaging, leading to diagnostic uncertainty and a potentially dangerous treatment modality.
Airway Obstruction following Carotid Endarterectomy
Authors: Kwok O. K. , Sun K. O. , Ahchong A. K. , Chan C. K.
Published: January 2019

Upper airway obstruction after carotid endarterectomy is a rare but potentially fatal complication of carotid endarterectomy. Upper airway obstruction is also a well recognized complication after neck surgery involving the thyroid gland and cervical spine. The airway obstruction usually develops slowly over a few hours and the onset is unpredictable. We report a patient who developed upper airway obstruction 16 hours following carotid endarterectomy. She required re-intubation in the intensive care unit (ICU). Fibreoptic assessment demonstrated severe supraglottic and glottic oedema. Tracheostomy was performed on day 2 postoperatively. Serial fibreoptic assessment of the upper airway showed gradual resolution of glottic edema and decanulation was successful on day 43.
Anaesthetists’ Knowledge of the QT Interval in a Teaching Hospital
Authors: Marshall S. D. , Myles P. S.
Published: January 2019

Many drugs used in anaesthesia may prolong the QT interval of the electrocardiogram (ECG), and recent U.S. Food and Drug Administration guidelines mandate monitoring of the ECG before, during and after droperidol administration. We surveyed 41 trainee and consultant anaesthetists in our Department to determine current practice and knowledge of the QT interval to investigate if this is a practical proposition. A response rate of 98% (40/41) was obtained. The majority of respondents expressed moderate to high levels of confidence in interpreting the ECG, and this was related to years of training (rho 0.36, P=0.024). A total of 27 respondents (65%) were able to correctly identify the QT interval on a schematic representation of the ECG, trainees 70% vs consultants 60%, P=0.51. When asked to name drugs that altered the QT interval, droperidol was included by 11 of the 40 respondents (28%); trainees 10% vs consultants 45%, OR 7.4 (95% CI: 1.3–41), P=0.013. Torsades de Pointes was correctly identified as a possible consequence of a prolonged QT interval by 65% of trainees and 70% of consultants, P=0.83. The results suggest that QT interval measurement is not widely practised by anaesthetists, although its clinical significance is well known, and interpretation would be unreliable without further education.
Arterial Oxygen Desaturation during only one of two Similar Thoracoscopic Procedures on the Same Patient
Authors: Pfitzner J. , Fowlie J. A. , Kishore M. , Michael A. S. , Lance D. G.
Published: January 2019

The present report describes two similar thoracoscopic procedures performed on the same 81-year-old male patient. Because acute hypoxia had developed during one-lung ventilation on the first occasion, serial blood gases were taken during the second. Also, whereas on the first occasion the non-ventilated lung had been left open to air when one-lung ventilation was initiated, on the second it was connected to an ambient pressure oxygen source with the object of theoretically enabling apnoeic oxygenation during lung collapse. It is argued that this fundamental difference in anaesthetic practice may have contributed to the improved oxygenation that was recorded during the second thoracoscopy.
Bilateral Brachial Plexopathy following Laparoscopic Bariatric Surgery
Authors: Brunette K. E. J. , Hutchinson D. O. , Ismail H.
Published: January 2019

This report describes a case of postoperative bilateral brachial plexopathy following laparoscopic bariatric surgery. The patient, a 39-year-old morbidly obese man, developed motor and sensory deficit, loss of reflexes, and pain in both arms postoperatively. Slow, but complete recovery occurred over nine months. We postulate that the head-up position in obese patients, without specific arm support, is a risk factor for brachial plexus injury.
Anaphylaxis to Cisatracurium following Negative Skin Testing
Authors: Fraser B. A. , Smart J. A.
Published: January 2019

General anaesthesia for the patient with a history of anaesthesia-related anaphylaxis is challenging. Precautions against anaphylaxis and the use of skin test negative drugs can reduce but not eliminate the risk. In the majority of such cases, subsequent anaesthesia is uneventful. However, the absence of a clearly identified triggering agent increases the difficulties facing the anaesthetist. We present a case of anaphylaxis to cisatracurium following a negative skin test.
Endotoxin Stimulated Interleukin-10 Production is Enhanced by Adenosine. Possible Key to Septic Shock Associated Immune Deficiency?
Authors: Nalos M. , Huang S. J. , Pandit R. , Mclean A. S.
Published: January 2019

The aim of this bench study was to investigate whether adenosine influences secretion of interleukin-10 (IL-10) in human whole blood culture stimulated with lipopolysaccharide. Whole blood from healthy human volunteers was mixed ex vivo in 1:1 ratio with RPMI 1640 culture medium and subsequently cultured at 37°C with or without adenosine (total of 120 μM added in four aliquots over two hours) in the presence or absence of 100 ng/ml lipopolysaccharide for four and eight hours, respectively. There was only a minimal IL-10 production after four hours of culture regardless of the experimental conditions. However, lipopolysaccharide stimulated whole blood cultures with added adenosine released large amounts of IL-10 after eight hours. The response was similar whether adenosine was added before (5.99 pg/ml/106 leucocytes) or after (10.35 pg/ml/106 leucocytes) stimulation with lipopolysaccharide and inter-individual variation was present. In conclusion adenosine enhances lipopolysaccharide stimulated IL-10 production in whole human blood and may contribute to the IL-10 mediated immune dysfunction in sepsis.
Near-Hanging as Presenting to Hospitals in Queensland: Recommendations for Practice
Authors: Boots R. J. , Joyce C. , Mullany D. V. , Anstey C. , Blackwell N. , Garrett P. M. , Gillis S. , Alexander N.
Published: January 2019

Near-hanging is an increasing presentation to hospitals in Australasia. We reviewed the clinical management and outcome of these patients as they presented to public hospitals in Queensland. A retrospective clinical record audit was made at five public hospitals between 1991 and 2000. Of 161 patients enrolled, 82% were male, 8% were indigenous and 10% had made a previous hanging attempt. Chronic medical illnesses were documented in 11% and previous psychiatric disorders in 42%. Of the 38 patients with a Glasgow Coma Scale score (GCS) of 3 on arrival at hospital, 32% returned to independent living and 63% died. Fifty-two patients received CPR, of whom 46% had an independent functional outcome. Independent predictors of mortality were a GCS on hospital arrival of 3 (AOR 150, CI 95% 12.4–1818, P<0.001), taking plain X-rays of the cervical spine (AOR 0.06, CI 95% 0.004–0.97, P=0.047) and contact with the ground (AOR 0.03, CI 95% 0.002–0.62, P=0.02). Only 66% had imaging of the cervical spine performed with other imaging performed infrequently. There were three laryngeal, two hyoid bone and three cervical spine injuries and one carotid dissection. The number of cervical spine X-rays required to find a significant cervical spine fracture was 54. Near-hanging presenting to hospital with a poor conscious state or even cardiac arrest can have a favourable clinical outcome. Radiological investigations are infrequently performed despite a low GCS precluding early accurate assessment. Given the general favourable outcome, an aggressive approach to searching for correctable injuries is recommended.
Tracheal Resection for Critical Tracheal Occlusion due to Intraluminal Tumour
Authors: Zhong T. , Wang Y. , Story D. A.
Published: January 2019

Anaesthesia for tracheal resection requires careful planning by an experienced team. We report a case of urgent tracheal resection for a vascular tumor in a 41-year-old man who was a heavy smoker. The tumour occupied most of his trachea. A CT reconstruction of the tumor assisted in planning. Perioperative tracheal laser therapy and cardiopulmonary bypass were not used due to concerns about excessive bleeding. Intraoperative airway management involved an upper endotracheal tube placed by the anaesthetist and a second, lower, endotracheal tube placed by the surgeon. The existing evidence for anaesthesia management of tracheal resection is currently limited to case reports. This case illustrates how preoperative imaging and careful planning can lead to a successful outcome, despite the potentially life-threatening nature of the pathology and the surgery.
Successful Resuscitation of an ASA 3 Patient following Ropivacaine-induced Cardiac Arrest
Authors: Khoo L. P. Y. , Corbett A. R.
Published: January 2019

A patient with severe myocardial disease and acute-on-chronic renal failure was undergoing a brachial plexus block for formation of an arteriovenous fistula when accidental intravascular injection of ropivacaine resulted in ventricular fibrillation. Cardiopulmonary resuscitation was instituted immediately and the advanced life support algorithm was followed until the return of sinus rhythm. Although, in comparison with bupivacaine, ropivacaine appears to be a safer local anaesthetic agent in the setting of intravenous injection, the emphasis on safety should remain a priority. Awareness of the risk of central nervous system and cardiovascular toxicity and preparation for immediate commencement of resuscitation in the event of toxicity remain of paramount importance.
The Relationship between Calculated Effect-site Sevoflurane Levels and Awakening from Anaesthesia
Authors: Kennedy R. R. , Sakowska M. M.
Published: January 2019

We have previously described a system that displays real-time estimates of effect-site sevoflurane concentrations. Estimates of effect-site levels should be similar to minimum alveolar concentration (MAC) values, which are determined after allowing time for equilibrium. This study aimed to determine estimated effect-site sevoflurane concentrations at awakening from routine anaesthesia and to compare this with published estimates of MAC-awake. If these values were similar, this would validate our approach to the calculation of effect-site concentration. Sixty-five patients undergoing a variety of surgical procedures were observed. Prior to disconnection from the breathing circuit, forward estimates of effect-site sevoflurane were recorded. Patients were observed in the postanaesthesiacare unit and the time at which they responded to comm and wasrecorded. Age-adjusted effect-site sevoflurane at the time of awakeningwas determined. Correlation with patient, surgical and anaestheticfactors includingage, gender, ASA status and intraoperative opioid usage were explored. Mean age-adjusted calculated effect-site concentration at awakening was 0.59 (SD 0.27) vol%. This value is within the range of values determined for MAC-awake of sevoflurane. There was no correlation with any of the demographic or anaesthetic factors, but patients undergoing major surgery woke at a significantly lower mean sevoflurane level. These results support the use of effect-site sevoflurane concentration to guide administration of anaesthesia.
The Introduction of Halothane into Clinical Practice: The Oxford Experience
Authors: O'Brien H. D.
Published: January 2019

This paper reviews the clinical situation in anaesthesia before the introduction of halothane into clinical practice in 1956, emphasising the limitations of agents available at the time. The background to the development of halogenated hydrocarbon compounds as anaesthesia agents is presented, including the involvement of Imperial Chemical Industries in England. The Nuffield Department of Anaesthetics was involved in the clinical trials and the designing and execution of these. The results of their work and the problems encountered are presented.
“The Anaesthetist” 1933—An Iconic Australian Medical Photograph
Authors: Cooper M. G.
Published: January 2019

Harold Cazneaux was the greatest Australian photographer of the early 20th century. In 1933, he took this image entitled ‘The Anaesthetist’. It is an important documentation of a clinical anaesthetist of the era and was exhibited internationally. Such photographs of specific medical scenarios are rare and valuable. The anaesthetist is Dr Frederick J. Bridges who worked at Royal Prince Alfred and Royal North Shore Hospitals in Sydney. He is using a Clements ether vaporizer which was Australian made. The patient is Cazneaux's daughter. Cazneaux has captured perfectly the care and concern of the anaesthetist for his patient.
Inoprotection: The Perioperative Role of Levosimendan
Authors: Soeding P. F. , Royse C. F. , Wright C. E. , Royse A. G. , Angus J. A.
Published: January 2019

Levosimendan is emerging as a novel cardioprotective inotrope. Levosimendan augments myocardial contractility by sensitising contractile myofilaments to calcium without increasing myosin adenosine triphosphatase activity or oxygen consumption. Levosimendan activates cellular adenosine triphosphate-dependent potassium channels, a mechanism which is postulated to protect cells from ischaemia in a manner similar to ischaemic preconditioning. Levosimendan may therefore protect the ischaemic myocardium during ischaemia-reperfusion as well as improve the contractile function of the heart. Adenosine triphosphate-dependent potassium channel activation by levosimendan may also be protective in other tissues, such as coronary vascular endothelium, kidney and brain. Clinical trials in patients with decompensated heart failure and myocardial ischaemia show levosimendan to improve haemodynamic performance and potentially improve survival. This paper reviews the known pharmacology of levosimendan, the clinical experience with the drug to date and the potential use of levosimendan as a cardioprotective agent during surgery.
Thrombocytopenia in Septic Shock Patients—A Prospective Observational Study of Incidence, Risk Factors and Correlation with Clinical Outcome
Authors: Sharma B. , Sharma M. , Majumder M. , Steier W. , Sangal A. , Kalawar M.
Published: January 2019

The objectives of the study were to study the incidence of various degrees of severity of thrombocytopenia in septic shock, the risk factors for its development and the correlation with clinical outcome. Complete blood counts, chemistry panel, arterial lactate, serum cortisol, APACHE II score, logistic organ dysfunction score and SOFA score were determined in 69 septic shock patients within 24 hours of admission or onset of septic shock. We followed the patients until they died or for six months to determine the mortality rate. The incidence of thrombocytopenia in our study group was 55%. Patients with thrombocytopenia had significantly higher serum creatinine, SOFA score, vasopressor requirement, lower PaO2/FiO2 ratio and higher mortality than those without thrombocytopenia (P <0.05). Higher SOFA score, low PaO2/FiO2 ratio and high vasopressor dose were independent risk factors for development of thrombocytopenia. The presence of thrombocytopenia had significant correlation with SOFA score (P=0.008). On receiver-operator characteristic curve analysis, platelet count was found to be predictive of increased mortality (area under curve=0.56). Thrombocytopenic patients had 1.4 times the risk of mortality and lower survival probability at six months (log rank test P=0.03). In conclusion, thrombocytopenia is common in septic shock and is associated with worse clinical outcome. Higher SOFA score, low PaO2/FiO2 ratio and high vasopressor dose are independent risk factors for development of thrombocytopenia in septic shock.
Propofol-Induced Changes in Myoplasmic Calcium Concentrations in Cultured Human Skeletal Muscles from RYR1 Mutation Carriers
Authors: Migita T. , Mukaida K. , Kawamoto M. , Kobayashi M. , Nishino I. , Yuge O.
Published: January 2019

Malignant hyperthermia is a pharmacogenetic disorder caused by autosomal dominant mutations in the ryanodine receptor type 1 gene. Propofol has been reported as a safe anaesthetic for malignant hyperthermia susceptible patients but has not been tested on cultured cells from patients with the ryanodine receptor type 1 mutation. The aim of this study was to determine whether propofol could trigger abnormal calcium fluxes in human myotubes isolated from malignant hyperthermia susceptible patients harbouring the native ryanodine receptor type 1 mutation. Muscle specimens were obtained from the patients to diagnose malignant hyperthermia disposition and the calcium-induced calcium release test and molecular genetic analyses were performed. Using the calcium sensitive probe Fura 2, we determined the 340/380 nm wavelength ratios by measuring alterations in calcium homeostasis in isolated myotubes from cultured skeletal muscle specimens. Two patients, one with ryanodine receptor type 1 R2508C and one with the L4838V mutation had accelerated calcium-induced calcium release rates. The 340/380 nm ratios increased when the propofol concentration exceeded 100 μM. The half-maximal activation concentrations (EC) for propofol from patients 1 and 2 were 181.1 and 420.5 μM, respectively. Increases in calcium concentrations in response to propofol dosage were limited to doses at least 100-fold greater than those used in clinical settings. These observations correlate well with clinical observations that propofol does not trigger malignant hyperthermia in susceptible humans.
The Preoperative Detection of Risk of Anaphylaxis during Anaesthesia
Authors: Fisher M. M.
Published: January 2019

In 144 patients who were referred to an anaesthetic allergy clinic because of perceived risk of anaphylaxis during anaesthesia, the only ‘at risk’ group that could be identified was patients with a history of unexplained severe adverse reaction during previous anaesthesia. Twenty-two of 45 patients with such a history had positive skin tests to an anaesthetic drug. Twenty-one positive tests were to neuromuscular blocking drugs and one to an opiate. In 18 of these patients the medical records were available and an adverse event had been recorded consistent with anaphylaxis. On the contrary, investigation of patients without a previous adverse reaction did not appear to be of value. These findings suggest that those patients with a history of a severe undiagnosed adverse event during previous anaesthesia should be investigated with preoperative skin-testing before undergoing further elective surgery.
Propofol-Induced Hyperamylasaemia in a General Intensive Care Unit
Authors: Nanas S. , Angelopoulos E. , Tsikriki S. , Kritikos K. , Voutsinas E. , Zervakis D. , Kanaloupiti D. , Pratikaki M. , Roussos C.
Published: January 2019

This study examined the incidence of hyperamylasaemia, in the absence of other plausible causes of pancreatic dysfunction, in intensive care unit (ICU) patients who received propofol.

One-hundred-and-seventy-two consecutive patients of a general ICU who stayed for more than 24 hours were studied. Patients with a diagnosis consistent with elevated serum amylase levels at admission were excluded from the study, as were patients who had received medications known to raise serum amylase levels. Forty-four patients 53 ± 20 years of age and median duration of ICU stay of five days (range two to 55) were eligible. Thirty of those, aged 54 ± 21 years and median duration of ICU stay of five days (range two to 27) received continuous infusion of propofol for sedation (maximum dose 45 μg/kg/min).

Of the 30 patients who received propofol, 16 (53%) developed hyperamylasaemia (125 to 466 IU/l) after two to nine days of continuous infusion. Liver and kidney function remained normal throughout the observation period. Of the 14 patients who did not receive propofol (aged 51 ± 18 years), only two (14%) developed hyperamylasaemia, a significantly lower incidence (P=0.021).

Propofol infusion is associated with biochemical evidence of pancreatic injury. Amylase levels monitoring of propofol-sedated patients is warranted.
The Influence of Flushing Epidural Catheters before use on Detection of Intravenous Placement: An in Vitro and in Vivo Study
Authors: Bell D. N. , O'Connor A. , Leslie K.
Published: January 2019

Undetected intravenous placement of epidural catheters is rare but potentially fatal and no perfect identification method exists. Epidural catheters may be flushed before insertion to identify faulty epidural catheters, or to prime the system with local anaesthetic. We hypothesised that flushing epidural catheters before insertion may delay the detection of intravenous placement. We investigated our theory using both in vitro and in vivo models. The in vitro component examined flowrates in flushed and unflushed epidural catheters, using conditions designed to mimic epidural venous pressure. The in vivo component examined the flow within flushed and unflushed epidural catheters inserted into the forearm veins of 20 anaesthetised patients, using a randomised crossover design. The endpoint utilised for both components was the time taken for frank blood to reach the 20 cm mark on the epidural catheter. Blood flow to the 20 cm mark on the epidural catheter was significantly faster in the unflushed catheters than the flushed catheters, both in vitro and in vivo (in vitro, unflushed median = 18.6 s (range: 18.0 to 20.5 s), flushed 37.6 s (32.6 to 91.2 s), P=0.0009; in vivo, unflushed 9.2 seconds (range 5.0 to 35.3 s), flushed 19.2 s (10.6 to 47.4 s), P=0.003 in vivo). Flushed catheters also demonstrated a greater variability in the range of flowrates. Flushing epidural catheters before insertion may delay the detection of intravenous placement.
Supplemental Jet Ventilation in Conscious Patients following Major Oesophageal Surgery
Authors: Bingold T. M. , Scheller B. , Kloesel S. , Wissing H. , Zwissler B. , Byhahn C.
Published: January 2019

Intensive care unit patients are at particular risk of respiratory failure after major abdominal surgery. Non-invasive ventilation or application of continuous positive airway pressure through a face mask may stabilise respiratory function and avoid the need for endotracheal re-intubation. However, there are various contraindications to noninvasive ventilation and/or tracheal re-intubation, such as recent oesophageal anastomosis, anastomotic leakage or tracheal stenting for tracheo-oesophageal fistula. A specific management strategy consisting of continuous intratracheal jet ventilation to support spontaneous respiratory function is described in two patients with contraindications to noninvasive ventilation or mask continuous positive airway pressure after major oesophageal surgery.
Bilaterally Absent Pupillary Responses: Not Always a Bad Sign
Authors: Carter B. G. , Butt W. , Taylor A.
Published: January 2019

Pupillary responses are a simple test commonly used as a predictor of outcome after severe brain injury. It is also common for clinicians to associate bilaterally absent pupillary responses with very poor prognosis. We report a series of cases of severely brain injured children with bilaterally absent pupillary responses who had favourable outcomes. From a group of 89 patients with brain injury, 32 had bilaterally absent pupillary responses and six (four with traumatic brain injury and two with infective brain injury) subsequently had favourable outcomes. This represents 18.8% of patients and should be a reminder to clinicians that the clinical sign of bilaterally absent pupillary responses is not always associated with a hopeless outcome.
The Perils of Pointing the Finger: A Lesson for Dr Haygarth
Authors: Paull J. D.
Published: January 2019

Mr William Russ Pugh, well known for his anaesthetic activities, and probably the first in Australia to administer ether anaesthesia for a surgical operation in May 1847, was involved in several court cases in Launceston, Tasmania in 1842 and 1843. At that time Tasmania was known as Van Diemen's Land. Two of the most dramatic cases ensued after a young doctor, Dr Burton George Haygarth, a recent arrival in the colony of Van Diemen's Land, was persuaded to accuse Pugh of manslaughter. Because of Pugh's standing in Launceston the cases attracted enormous public attention and support for Pugh. The outcome for Dr Haygarth was very unpleasant and not something which he had anticipated.
A Bibliography of Articles on the History of Anaesthesia and Medicine in Anaesthesia and Intensive Care 1972-2005
Authors: Cooper M. G.
Published: January 2019

This bibliography references all articles on the history of anaesthesia and medicine published in Anaesthesia and Intensive Care from volume 1 in 1972 to 34 years later when the first symposium on Anaesthesia History was published in the June issue of the Journal (Vol 33, 2005).
The Performance of Dräger Oxylog Ventilators at Simulated Altitude
Authors: Flynn J. G. , Singh B.
Published: January 2019

Ventilated patients frequently require transport by air in a hypobaric environment. Previous studies have demonstrated significant changes in the performance of ventilators with changes in cabin pressure (altitude) but no studies have been published on the function of modern ventilators at altitude. This experiment set out to evaluate ventilatory parameters (tidal volume and respiratory rate) of three commonly used transport ventilators (the Drager Oxylog 1000, 2000 and 3000) in a simulated hypobaric environment. Ventilators were assessed using either air-mix (60% oxygen) or 100% oxygen and tested against models simulating a normal lung, a low compliance (Acute Respiratory Distress Syndrome) lung and a high-resistance (asthma) lung. Ventilators were tested at a range of simulated altitudes between sea level and 3048 m. Over this range, tidal volume delivered by the Oxylog 1000 increased by 68% and respiratory rate decreased by 28%. Tidal volume delivered by the Oxylog 2000 ventilator increased by 29% over the same range of altitudes but there was no significant change in respiratory rate. Tidal volume and respiratory rate remained constant with the Oxylog 3000 over the same range of altitudes. Changes were consistent with each ventilator regardless of oxygen content or lung model. It is important that clinicians involved in critical care transport in a hypobaric environment are aware that individual ventilators perform differently at altitude and that they are aware of the characteristics of the particular ventilator that they are using.
Predictors of Outcome of Ruptured Aortic Aneurysms in a Metropolitan Hospital
Authors: Botha J. A. , Tiruvoipati R. , Last G. C. , Somjen G. , Chue W.-L.
Published: January 2019

The mortality in patients presenting with ruptured abdominal aortic aneurysm remains high. In this study we aimed to assess the outcome and factors predicting the mortality in patients admitted to a teaching hospital with the diagnosis of ruptured abdominal aortic aneurysm.

During the study period (July 2001 to July 2007) all patients admitted with a diagnosis of a ruptured abdominal aortic aneurysm were included. There was a total of 62 patients with a mean age of 76 years. The hospital mortality was 32.3% (20 patients). Twelve patients (19.4%) were discharged home, 25 patients (40.3%) were discharged to rehabilitation and five patients (8%) were discharged to other hospitals for further care. There was a significant difference between survivors and non-survivors in age, loss of consciousness at presentation and duration of hospital stay. Logistic regression analysis of these variables suggests the presence of chronic obstructive pulmonary disease (P=0.04, odds ratio 6.7, 95% confidence interval 1.1 to 41.3) and age (P=0.02, odds ratio 1.2, 95% confidence intervals 1.0 to 1.3) to be independently associated with mortality. These results compare favourably with published Australian as well as the international data.
Mismatched Connections
Authors: Houghton I. T.
Published: January 2019

Historically, anaesthetic equipment manufacturers used a number of differently-sized connectors in anaesthetic breathing systems. This gave rise to the potentially dangerous possibility of mismatched taper connections and a failure to create a gas-tight breathing system capable of ventilating a patient. The British Standard 3849 of 1965 attempted to correct this problem but manufacturers’ designs, in some cases, still caused problems. The problem was aggravated by a move to adopt a slightly different International Standards Organisation design. By the time that universally-interchangeable connectors were widespread twenty years later, disposable breathing systems had replaced the old, heavy metal connectors.
The Geoffrey Kaye Museum of Anaesthetic History: Creating a Meaningful Display
Authors: Ball C.
Published: January 2019

There have been several displays created at the Geoffrey Kaye museum over the last 20 years. The current display is the culmination of a new professional approach to the management of the collection. A timeline has been created to enhance conducted tours and to allow self-guided tours. The creation of this display brought new challenges to those responsible for the collection but has resulted in a contemporary and exciting display that has been appreciated by many visitors.
Critical Care of the Patient with Acute Pancreatitis
Authors: Hasibeder W. R. , Torgersen C. , Rieger M. , Dünser M.
Published: January 2019

Acute pancreatitis is an inflammatory process of the pancreas with variable involvement of regional tissues and remote organs. This review gives a comprehensive overview of the aetiology, pathophysiology, diagnosis and therapy of acute pancreatitis relevant to the intensivist. Recent international guidelines on the management of acute pancreatitis are summarised.

Eighty percent of acute pancreatitis episodes are related either to gallstones or to alcohol abuse. Independent of its aetiology, the pathophysiologic hallmark of acute pancreatitis is the premature activation of trypsin, which leads to massive pancreas inflammation, systemic overproduction of pro-inflammatory mediators and ultimately remote organ dysfunction. All guidelines agree that the diagnosis of acute pancreatitis should include clinical symptoms, increased serum amylase or lipase levels and/or characteristic findings on computed tomography. Endoscopic retrograde cholangiopancreatography is recommended as a causative therapy in patients with acute cholangitis or a strong suspicion of gallstones. All guidelines underline the importance of vigorous fluid resuscitation and supplemental oxygen therapy and prefer enteral over parenteral nutrition, with the majority favouring the nasojejunal route. In view of lacking scientific evidence, antibiotic prophylaxis to prevent infection of pancreatic necroses is discouraged by most guidelines. Computed tomography-guided fine needle aspiration is the technique of choice to differentiate between sterile and infected pancreas necrosis. While sterile pancreatic necrosis should be managed conservatively, infected pancreatic necrosis requires debridement and drainage supplemented by antibiotic therapy. Surgical necrosectomy is the traditional approach, but less invasive techniques (retroperitoneal or laparoscopic necrosectomy, computed tomography-guided percutaneous catheter drainage) may be equally effective.
A Randomised, Double-blind Comparison of Three Different Volumes of Hypobaric Intrathecal Bupivacaine for Orthopaedic Surgery
Authors: Imbelloni L. E. , Gouveia M. A. , Vieira E. M. , Cordeiro J. A.
Published: January 2019

This study was designed to evaluate different doses of hypobaric 0.15% bupivacaine administered to achieve unilateral orthopaedic surgery under subarachnoid block.

Using a randomised, double-blinded protocol, 150 ASA I to II patients scheduled for elective unilateral orthopaedic surgery were allocated to received a subarachnoid block with hypobaric bupivacaine 0.15% 4.5 mg (3 ml) (Group 1), 6.0 mg (4 ml) (Group 2) or 7.5 mg (5 ml) (Group 3). Measurements included cardiovascular and haemodynamic stability, incidence of unilateral anaesthesia, time to recover from motor block, postoperative urinary retention, transitory neurological symptoms and postdural puncture headache.

There was a dose-dependent increase in the duration of the block, from 1:55±00:20 hours (4.5 mg) to 2:15±00:22 hours (6.0 mg) and 3:15±00:31 hours (7.5 mg). The sensory block in the operated limb was significantly higher than that in the non-operated limb at all times. The increasing dose resulted in an increase of the motor block score. Seventy percent of patients had unilateral block. It was concluded that the spinal anaesthesia in all groups was suitable for single limb orthopaedic surgery. The smallest dose (4.5 mg) of hypobaric 0.15% bupivacaine resulted in more unilateral blocks, with narrower distribution and shorter duration.
The Pulmonary Artery Catheter Sleeve – Protective or Infective?
Authors: Corcoran T. B. , Grape S. , Duff O. , Perry P L. , Murray R.
Published: January 2019

The use of sterile plastic sleeves to protect pulmonary artery catheters (PAC) may decrease infection risk. The catheter may require manipulation but contamination of the sleeve risks inoculating organisms into the patients. We sought to determine whether the sleeve remains sterile and for how long.

We conducted a prospective observational study to culture the components of the PAC in a critically ill population. Upon removal we cultured 1) the PAC tip, 2) the PAC introducer exit site, 3) the PAC introducer hub and 4) a sterile irrigant solution which ran down the inside of the protective sleeve. Demographic, catheter and disease variables were also collected.

There were 102 PAC episodes amounting to 3952 catheter hours with a mean duration of catheterisation of 39.1 (24.2) hours. There were 17 positive culture results, of which six were positive sleeve fluid cultures. In three of these patients the exit site was culture positive, and the same organism was isolated as within the sleeve. No patient had a positive blood culture. There was no difference between those with and without a positive sleeve culture in terms of demographic or disease variables.

The protective sleeve of the pulmonary artery catheter does not remain sterile and should not be considered as a sterile barrier. We believe that manipulating the PAC within the sleeve carries the risk of inoculating the patient with pathogenic organisms. The duration of sterility remains to be determined.