bluuebunny/crossref_metadata_2025 huggingface dataset:
18 años y los que están por venir
Authors: León García Ricardo
Published: February 2023

Con la entrega de este número 56 cumple la mayoría de edad toda esa gente que nació al mismo tiempo que aparecía el primer ejemplar de la llamada en-tonces Revista de las Fronteras y que a partir de su edición doce se nombró Cuadernos Fronterizos.
Colonialismo interno, un concepto subversivo
Authors: Singer Sochet Martha
Published: February 2023

Entre los diversos aportes de la obra de Pablo González Casanova, cabe destacar la mirada que ofrece a través de la categoría de colonialismo interno. Con su examen, fortalecemos los merecidos festejos por sus cien años de intensa, activa y productiva vida.
Pablo González Casanova. Breve semblanza de su trayectoria académica e intelectual
Authors: Hernández Fuentes José Roberto
Published: February 2023

El pasado 11 de febrero se cumplieron 100 años de la vida del más insigne sociólogo mexicano del siglo XX, Pablo González Casanova. Nacido en el año de 1922 en la ciudad de Toluca, Estado de México, su odisea intelectual y científica comenzó al tomar la decisión de estudiar la carrera profesional de derecho en la Facultad de Jurisprudencia de la Universidad Nacional Autónoma de México (UNAM), por la cual también, y en conjunto con la Escuela Nacional de Antropología e Historia (ENAH) y el Colegio de México, obtendría el grado de Maestro en Ciencias Históricas en 1947.
COVID-19 y medios digitales de educomunicación
Authors: Rey-Ronquillo Rubén R. , Machin-Mastromatteo Juan D.
Published: February 2023

En este trabajo analizamos el uso de los medios digitales de educomunicación (MDE) por docentes de educación superior. Los MDE refieren al uso de tecnologías de información y comunicación (TIC) para enriquecer las actividades educativas. Aquí destacamos los efectos de la pandemia en el uso de los MDE, según los resultados de entrevistas realizadas en línea a diez docentes de dos facultades, Ingeniería y Filosofía y Letras, de dos universidades, la Universidad Autónoma de Chihuahua (UACH) y la Universidad Nacional Autónoma de México (UNAM)
Antonio Castro López
Authors: Castro Hernández Antonio , Vázquez Rosa Elva
Published: February 2023

Prolífico pintor e ilustrador, Antonio Castro desarrolló su carrera en la región de Ciudad Juárez y El Paso, en donde es uno de los artistas más reconocido por su larga y fructífera trayectorias artística. Originario de La Noria, Zacatecas, lugar en el que nació en 1941, Antonio Castro llegó a la frontera cuando aún no cumplía los tres años, momento en el que su madre, María del Socorro López, una mujer recia y liberal de origen mexicano, nacida y criada en Estados Unidos, decidió regresar con sus dos hijos al país que dejó junto con su madre y hermanos a causa de la depresión de 1929. El padre de Antonio, Jesús María Castro, un hombre dedicado a la minería, permaneció en México.
Arte poética: La infinitud de Montemayor
Authors: Muñoz Margarita
Published: February 2023

Hablar de un personaje como Carlos Montemayor, cuyas dimensiones literarias, estéticas, y culturales trascienden nuestro país, no sólo resulta difícil sino, seguramente, insuficiente. El mundo donde se desenvolvió, y que decidió desentrañar, comprender y amar, es como un caleidoscopio que llama a adentrarse en una dimensión tan rica, vasta y variada como su obra: poeta, ensayista, traductor, novelista, cuentista y crítico, a través de su enorme acervo literario y su creatividad ilimitada abordaba cualquier tema con sensibilidad y erudición.
Comunalidad: el modo de vida de los pueblos mesoamericanos
Authors: Maldonado Alvarado Benjamín
Published: February 2023

Exposición comprensida del concepto de comunalidad, rasgo característico de las comunidades indpigenas mesoamericanas que se rigen por usos y costumbres.
La muerte, viva en las canciones populares mexicanas
Authors: Vázquez Reyes Óscar Martín , Flores Simental Raúl
Published: February 2023

Por medio de sus canciones los mexicanos se burlan de la muerte, la invocan, la retan, la añoran, la temen, la sienten su cómplice. Acompañadas de múltiples instrumentos musicales, las voces de hombres y mujeres hablan de ella. De tan presente en las canciones populares, se pensaría que es objeto de sesudos estudios académicos, pero quien pretenda escudriñar se ve obligado a empezar por lo básico, por establecer los orígenes de eso que Lomnitz llama “intimidad irónica” del mexicano con la muerte. Este artículo rescata la alusión a La Pelona en piezas mexicanas antiguas y recientes...
Pablo González Casanova: 100 años de remover conciencias
Authors: Pineda Jaimes Servando
Published: February 2023

En este 2022 cumplió su centenario de vida y por ese motivo, Cuadernos Fronterizos rinde un homenaje a su obra, trayectoria y pensamiento académico, caracterizado por ese don y talento natural en él, de remover conciencias. De ser un rebelde crítico, del gran humanista político.
Analysis of Climate Change Indices in Musanze District, Rwanda
Authors:   Rwanda Meteorology Agency, P.O Box 898 Kigali, Rwanda, Twahirwa Anthony , Oludhe Christopher ,   University of Nairobi, P.O Box 30197, 00100, Nairobi, Kenya, Omondi Philip ,   IGAD Climate Prediction and Application Centre, P.O. Box 10304, 00100 Nairobi, Kenya, Rwanyiziri Gaspard , Ndakize Sebaziga , Guhirwa Sandrine
Published: February 2023

This study used daily rainfall, minimum temperature, and maximum temperature data from the Rwanda Meteorology Agency (Meteo Rwanda) for the years 1983 - 2016 to analyze climate change indices in the Musanze district of Rwanda. Rainfall and temperature extreme indices were determined using the methodology provided by Expert Team on Climate Change Detection Monitoring Indices (ETCCDMI). Climate Data Tool (CDT), which is R-based package developed by International Research Institute for Climate and Society (IRI) was used to compute the indices. Sen's slope estimator and the modified Mann-Kendall (m-MK) test were both applied to identify trends and determine the degree of change. The Monthly Temperature (TXx, TXn, TNx, and TNn) indices generally showed a warming in the eastern and a cooling in the western parts of the district, according to the trend results; however, the Minimum tail of temperature indices showed a slightly reduced cooling which is a sign of warm nights and hot days in highland areas of volcanic region. For the same period, the district's eastern regions have higher precipitation intensity and wetness, which gradually declines toward the middle and western regions. In addition, a considerable upward trend in the annual total precipitation for days above the 95th percentile (very wet days) and the annual count for precipitation equal or greater than 20 mm (very heavy precipitation days). Additionally, temperature indices showed a large rise in the minimum and maximum values of daily minimum temperatures, annual minimum and maximum values of daily maximum temperatures, and the percentage of days with daily maximum temperatures above the 90th percentile (warm days). In view of these evolving trends in weather and climate patterns, the study recommends local farmers and other stakeholders involved in socioeconomic activities in the district to implement the necessary climate change mitigation and adaptation measures.
Prospects of ecological tourism development in Northern Asia protected natural areas. The case of Dzherginsky Reserve (Republic of Buryatia)
Authors:   Baikal Institute of Environmental Management, SANZHEEV Erdeni , RADNAEV Nima ,   Dzherginsky State Nature Reserve, TSYRENDORZHIEVA Tatyana ,   Banzarov Buryat State University, SHIRAPOVA Sendema ,   Banzarov Buryat State University
Published: February 2023

The purpose of the study is to explore the current state of tourism development in natural protected areas Republic of Buryatia using the case of Dzherginsky Reserve and to identify favorable and negative factors influencing the development of tourism, to determine the main directions for the development of ecological tourism on its territory. Research methods. The main research method was the comparative geographical method. This method helped reveal the features of the development of tourism in Dzherginsky Reserve in comparison with Baikalsky and Barguzinsky Reserves. The statistical method using the dynamics of visitors in the reserves the Republic of Buryatia was determined. In article shown the number of visitors in Dzherginsky reserve is less than in other reserves. The main prerequisites analyzed for the development of tourism in the reserve and factors identified hindering its development. The cartographic method applied in the analysis of the economic-geographical and transport-geographical position of the reserve. On the method of analogies based, identified and substantiated promising directions for the development of ecological tourism in Dzherginsky Reserve. Research results. In the course of the work carried out, that the main factors revealed hindering the development of tourism in Dzherginsky Reserve are the transport inaccessibility of the territory, the lack of access roads with a hard surface, and the environmental and educational nature of the activity. The analysis showed that since 2008 observed the positive dynamics of the number of reserve visitors. Due to the coronavirus pandemic, there has been a decrease in the number of tourists, which is a temporary phenomenon. The reserve has developed five ecological tours designed for tourists with physical training. The reserve has an ethnotourist complex to accommodate tourists. Conclusions. The development of ecological tourism is a promising area of activity for Dzherginsky reserve, for which there are all prerequisites. However, in order for ecological tourism to be profitable, cooperation with government agencies, representatives of the tourist industry and the local population is necessary. In this regard, it is important to use the existing experience of Baikalsky reserve in training the local population and attracting tourists to serve. At the present stage, it is necessary to develop program documents in which it is necessary to provide for measures to mitigate adverse factors.
The electrophysiology of semantic processing in individuals with autism spectrum disorder: A meta-analysis
Authors: Yuan Danfeng , Yang Xiangyun , Yang Lijuan , Li Zhanjiang
Published: February 2023

Language deficits vary widely among people with autism spectrum disorder (ASD). However, the semantic processing of autism and its underlying electrophysiological mechanism are still unclear. PubMed, Web of Science, and Embase were searched for event-related potential (ERP) studies on semantic processing in people with ASD published in English before September 1, 2022. Pooled estimates were calculated by fixed-effects or random-effects models according to the heterogeneity. The potential moderator was explored by meta-regression and subgroup analysis. This meta-analysis has been registered on PROSPERO (no. CRD 42021265852). Our study included 14 articles and 18 studies, including 254 ASD patients and 262 controls. Compared to the controls, ASD patients showed a reduced N400 amplitude (Hedges' g = 0.350, P<0.001) in response to linguistic stimuli instead of non-linguistic stimuli. The N400 amplitude can be affected by verbal intelligence and gender. The reduced overall N400 amplitude in ASD patients under linguistic stimuli suggests a linguistic-specific deficit in semantic processing in individuals of ASD. The decrease of N400 amplitude might be a promising indication of the pool language capacity of ASD.
An Investigation into How L-Carnitine Consumption Prevents Contrast-induced Nephropathy: A Case Study of Patients Getting Coronary Angiograms in Iran
Authors: Ramezanzade Elham , Nikfarjam Salman , Jafari Atefeh , Sanchooli Abdolhasan , Salari Arsalan , Ashouri Asieh
Published: February 2023

Background
Contrast-induced nephropathy is a critical complication of coronary angiography and angioplasty. The overall goal of this inquiry is to evaluate how L-carnitine can help prevent contrast-induced nephropathy in patients getting coronary angiograms in an Educational-Therapeutic-Research Center.
Methods
As a randomized clinical trial, this experiment was conducted in an Educational-Therapeutic-Research Center in Rasht, Iran. 286 patients (143 patients receiving L-carnitine and 143 patients in the control group) who underwent elective angiography and PCI (Percutaneous Coronary Intervention) in 2020 were recruited. The treatment group patients consumed 3 g of L-carnitine three times a day, 24 hours before the procedure (3 g before PCI), and 3 g after PCI. Also, the subjects of the control group were not given any L-carnitine.
Results
The mean age of patients in the intervention group was 58.6 ± 12 years. In the intervention group, 88 (61.5%) were male, and 55 were female. In the control group, 90 (64.3%) were male, and 53 (35.7%) were female. The results showed that 11 patients (3.8%) had nephropathy in the studied patients and 7 patients (4.9%) and 4 patients (2.8%) had nephropathy in the treatment and control groups, respectively. The results of the Fisher test showed that the frequency distribution of nephropathy in the two groups was not significantly different (p = 0.54). The linear regression analysis indicated that the GFR levels in the intervention group is significantly greater than the control group [P = 0.012, β = 5.520 (CI = 1.24–9.80)].
Conclusions
Our results showed that L-carnitine significantly improved renal function by increase in GFR in patients undergoing angiography and angioplasty.
Velocity Field of Submerged Multiple Non-buoyant Jet Groups in Crossflow
Authors: Ali Md. Shahjahan
Published: February 2023

This paper presents the results of a laboratory study on the three-dimensional velocity field of circular non-buoyant multiple jets discharged into a perpendicular crossflow. Two to four momentum jets were taken in a group with spacings five times the jet diameters and the three-dimensional velocity field was measured using an Acoustic Doppler Velocimetry (ADV) system to investigate the interaction of jets with crossflow. The rear jets were found to be less deflected than the front one due to the reduction of effective crossflow velocity because of the sheltering effect as well as the entrainment demand. For a jet spacing of 5 times of jet diameter, the effective crossflow to upstream approach velocity ratios were found to vary between 0.4 and 0.6 regardless of the momentum length scale and the number of jets in a group. The rates of velocity reduction in between jets observed in this study, were favorably compared with previous results, where velocity was inferred from Laser Induced Fluorescence (LIF) measurements. The findings of this study can be used to predict the jet trajectories and dilutions of multiple jets in crossflow as well as modeling of discharges from multiport diffusers. This work will be helpful for the engineers and other scientists dealing with the disposal of wastewater, thermal effluents, or air pollutants into flowing environments.
Capturing provenance information for biomedical data and workflows: A scoping review
Authors: Gierend Kerstin , Krüger Frank , Genehr Sascha , Hartmann Francisca , Siegel Fabian , Waltemath Dagmar , Ganslandt Thomas , Zeleke Atinkut Alamirrew
Published: February 2023

Background:
Provenance enriched scientific results ensure their reproducibility and trustworthiness, particularly when containing sensitive data. Provenance information leads to higher interpretability of scientific results and enables reliable collaboration and data sharing. However, the lack of comprehensive evidence on provenance approaches hinders the uptake of good scientific practice in clinical research. Our scoping review identifies evidence regarding approaches and criteria for provenance tracking in the biomedical domain. We investigate the state-of-the-art frameworks, associated artifacts, and methodologies for provenance tracking.
Methods:
This scoping review followed the methodological framework by Arksey and O'Malley. PubMed and Web of Science databases were searched for English-language articles published from January 1, 2006, to March 23, 2021. Title and abstract screening were carried out by four independent reviewers using the Rayyan screening tool. A majority vote was required for consent on the eligibility of papers based on the defined inclusion and exclusion criteria. Full-text reading and screening were performed independently by two reviewers, and information was extracted into a pre-tested template for the five research questions. Disagreements were resolved by a domain expert. The study protocol has previously been published.
Results:
The search resulted in a total of 564 papers. Of 469 identified, de-duplicated papers, 54 studies fulfilled the inclusion criteria and were subjected to five research questions. The review identified the heterogeneous tracking approaches, their artifacts, and varying degrees of fulfillment of the research questions. Based on this, we developed a roadmap for a tailor-made provenance framework considering the software life cycle.
Conclusions:
In this paper we investigate the state-of-the-art frameworks, associated artifacts, and methodologies for provenance tracking including real-life applications. We observe that most authors imply ideal conditions for provenance tracking. However, our analysis discloses several gaps for which we illustrate future steps toward a systematic provenance strategy. We believe the recommendations enforce quality and guide the implementation of auditable and measurable provenance approaches as well as solutions in the daily routine of biomedical scientists.
A novel cuproptosis-related prognostic gene profiles in preeclampsia
Authors: Tang Xiaotong , Liu Yi , Zhang Yuanyuan
Published: February 2023

Background
Preeclampsia (PE) is one of the main causes of poor maternal and fetal outcomes, whose pathogenesis is complex and remains unclear. Cuproptosis is a novel identified form of programmed cell death. However, the link between cuproptosis and clinical outcome in PE is still less known.
Methods
Using RNA sequencing data in GEO database, we conducted functional enrichment analysis of GO, KEGG and GSEA, supported by linear regression model and ROC curve analysis, and summarized the role of cuproptosis related genes in preeclampsia.
Results
2831 differentially expressed genes (DEGs) related to PE were primarily summarized through multiple database analysis. Further intersected with 19 reported cuproptosis related genes (CRGs), and 5 CRGs were considered to be related to the pathogenesis of PE, including "NFE2L2", "PDHA1", "PDHB", "DLD", "GLS". Functional enrichment analysis of DEGs, CRGs and hub genes revealed identified "NFE2L2" as a key central gene. Pearson correlation analysis was used to analyze and showed that CRGs could be related to several maternal and fetal outcome factors, including the highest pregnancy blood pressure, placenta weight, umbilical blood flow PI, and neonatal weight. Linear regression equation revealed that the expression of "NFE2L2" was negatively correlated with the highest pregnancy blood pressure and umbilical blood flow PI but positively correlated with placental weight and neonatal weight. Further utilize of qPCR showed that the expression of these CRGs were significantly lower in placental tissues.
Conclusions
The cuproptosis pattern evaluated in our study may be used as potential prognostic factors in patients with PE and could provide new insights into disease progression.
Factors Responsible for Somali Universities Low Rankings: An Evidence-Based Review
Authors: Muhammad Faisal , Ahmed Muse , Mohamed Mohamed Dahir
Published: February 2023

Different factors affected the educational progress and quality of Somali Universities since the unfortunate civil war in 1988, followed by the collapse of the central state in 1991. The collapse of the central has severely dismantled all public social services in Somalia. As a result, the educational system of Somalia was not spared. Efforts by the local populations and the international community to reestablish the educational system to a pre-conflict level have yet to be sufficient, particularly in higher education. To that end, this paper reveals and documents some factors responsible for the low ranking of Somali universities. Some of these factors include a need for more suitable learning environments and facilities, research and publications, Industry income, international outlook, low percentage of budget allocation to education, etc. The abovementioned factors must be improved significantly to improve the performance and ranking of Somali Universities. One way to improve its performance is to increase government funding to higher education in its annual budget by 20.0%, coupled with increased community and international support.
Treatment of hypertriglyceridemia-induced pancreatitis by pancreatic duct stenting: a retrospective study
Authors: Chengsi Zhao , Weijie Yao , Anning Chen , Zuozheng Wang
Published: February 2023

Background
To evaluate the effectiveness and safety of pancreatic duct (PD) stenting under endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of patients with hypertriglyceridemia-induced pancreatitis ( HTGP ).
Methods
The clinical data of 84 patients with HTGP admitted to General Hospital of Ningxia Medical University between January 1, 2017, and July 1, 2020, were retrospectively analyzed. Patients were divided into a conservative group (n = 51) and a stent group (n = 33). The complication rate, transfer rate to intensive care unit (ICU), acute physiological and chronic health APACHE II score at 48 h of admission, triglyceride level and duration of enzyme-inhibiting drug use were compared between the two groups.
Results
A total of 84 patients with HTGP were enrolled, 68 males and 16 females with a mean age of (38.55 ± 9.63) years. The median triglyceride level at admission was 16.40 (11.85–31.33) mmol/L. All 33 patients in the stent group had successful pancreatic duct stent placed, a large amount of mucinous material filling of the pancreatic duct was clearly observed in 16 patients (48%). The incidence of persistent organ failure was higher in patients with this substance in the pancreatic duct [31.25% (5/16) versus 0% (0/17), P < 0.05]. After the treatment, leukocytes, amylase, triglycerides and APACHE II scores of both in conservative and stent group were significantly lower than those before the treatment(P < 0.05). Patients in the stent group had significantly lower APACHE II scores after treatment than those in the conservative group [(4.65 ± 2.63) versus (2.94 ± 1.45), P < 0.05]. The number of days of fasting, length of hospital stay, and duration of enzyme inhibiting drug use were significantly lower in the stent group than in the conservative group (P < 0.05). The incidence of local complications in the stent group was lower than that in the conservative group [0% (0/33) versus 11.76% (6/51), P < 0.05], and the overall complication rate was also significantly lower than that in the conservative group [9.09% (3/33) versus 47.06% (24/51), P < 0.05].
Conclusion
PD stent implantation is a safe and effective treatment strategy, which can quickly relieve abdominal pain, reduce hospitalization time and improve prognosis in patients with HTGP.
Conclusion
Pancreatic duct stenting is a safe and effective treatment strategy as it can rapidly relieve the clinical symptoms, reduce the length of hospital stay and improve the prognosis of patients with HTGP.
Trial Registration:
This study was registered as a single-centre, retrospective case series at chictr.org.cn.
Targeted Therapies for Breast and Lung Cancers by Using Propolis Loaded Albumin Protein Nanoparticles
Authors: Ghazy Mohamed G.M. , Hanafy Nemany A.N.
Published: February 2023

Cancer is a popular disease among many others that can threaten defiantly human life. This is not only because of its invasiveness but also because of its resistance and the highly effective cost of its treatment. Propolis is rich in natural sources of bioactive and polyphenolic compounds that have proven their strong effect on cancer cells such as MCF-7 and A549 cell lines. Propolis extract was inserted into the Albumin protein, Bovine Serum (BSA) conjugated to folic acid (FA) to increase control of its delivery and to increase their cellular uptake. The growth of MCF-7 and A549 was significantly decreased by propolis extract and BSA-propolis NPs after their incubation for 72h by (54 ± 0.01% and 45 ± 0.005%, P ≤ 0.001) and (20 ± 0.01% and 10 ± 0.005%, P ≤ 0.0001) respectively. Similarly, there is a significant inhibition in the growth of A549 obtained after their incubation (propolis extract and albumin-propolis NPs) for 72 h (15 ± 0.03% and 5 ± 0.01%, P ≤ 0.00001). Propolis extract and BSA-propolis NPs exhibited a greater effect on protein expression of MCF-7 and A549 showing significant modulation of caspase-3, cyclin D1, and LC3II. The result was supported by the presence of nuclear fragmentations and activation of acidic/neutral autophagosomes in AO/EB and DAPI stains. In the recent investigation, the expression of phospho-GSK3β (Ser9) (p < 0.001) increased significantly in MCF-7 and A549 cells after their exposure to propolis extract and BSA-propolis NPs. Results support the potency application of propolis and its encapsulation as an alternative therapeutic agent for cancer treatments instead of chemotherapies because of its action on multi-signaling pathways.
Isolation and structure elucidation of the compounds from Teucrium hyrcanicum L. and the investigation of cytotoxicity, antioxidant activity, and protective effect on hydrogen peroxide-induced oxidative stress
Authors: Ghasemi Saeed , Evazalipour Mehdi , Peyghanbari Nastaran , Zamani Ehsan , Bellstedt Peter , Molaee Mahan , Koohi Diba Eghbali , Yousefbeyk Fatemeh
Published: February 2023

Background: Teucrium hyrcanicum L. (family Lamiaceae) is widely distributed in the north and northwest of Iran. It has been used in form of tea, tonic, and tincture for the treatment of various diseases such as cough, rheumatism, and fever.
Methods: In this study, the total phenolic and flavonoid contents, antioxidant and cytotoxic activities of total extract and different fractions of T. hyrcanicum were measured. Furthermore, the potential ability of T. hyrcanicum to protect H2O2-induced oxidative stress was tested on NIH3T3 cell line. Then, the isolation and structure elucidation of the compounds were performed on the most potent fractions. Finally, the quantification of isolated compounds in total extract (TE) was done by HPLC method. Isolated phytochemicals were assessed for cytotoxic and antioxidant activity.
Results: The results indicated that the methanol fraction (MF) had the highest amount of phenolic and flavonoid contents (69.36 mg GAE/g extract and 68.95 mg QE/g extract). The highest radical scavenging activities were observed from MF and TE (IC50 44.32 and 61.12 μg.ml-1, respectively). The best cytotoxicity was obtained by ethyl acetate fraction (EF) against A431 and MCF7 (IC50 values of 235.4and 326.6 μg.ml-1, respectively). The pretreatment with MF exerts the highest reduction in malondialdehyde (MDA) formation (IC50= 2.51 μM, p<0.001) compared to the H2O2 group (5.77 μM). Also, MF significantly inhibited H2O2-induced Glutathione (GSH) oxidation (p<0.001). Furthermore, two phenolic compounds, including acteoside and quercetin were isolated and identified in MF and EF, respectively. The IC50 values of acteoside and quercetin in DPPH assay were 7.19 and 5.56 µg.ml-1, respectively. Both quercetin and acteoside significantly reduced the MDA formation and inhibited GSH oxidation which was comparable with BHA (as standard antioxidant) (p< 0.05). Acteoside demonstrated significant cytotoxicity against all tested cell lines (IC50=32 to 145 μg.ml-1). The HPLC quantification of isolated compounds revealed that the quantity of acteoside and quercetin in TE were 93.31 and 16.87 μg.mg-1, respectively.
Conclusions: The isolated compounds (quercetin and acteoside) had significant antioxidant activity and revealed protective effect on H2O2-induced oxidative stress which was comparable with BHA.
Fuzzy model multi-attribute decision-making under information systems
Authors: Sun Zhenduo , Kong Xiangzhi
Published: February 2023

This paper combines information systems with fuzzy pattern recognition and proposes an improved fuzzy pattern decision-making method based on it. The decision attributes and conditional attributes are selected according to the decision purpose, and the correlation coefficients of the decision attributes and conditional attributes are derived by combining the original attribute values using the correlation method to determine the weights of each conditional attribute, while the weights of the decision attributes are determined by the decision maker. The standard set and the set to be measured in the fuzzy model are constructed using the affiliation functions of the different attributes. The degree of proximity between the criterion set and the set to be tested is calculated and the solution that best exploits the advantages of the current stage is selected as the optimal solution. The introduction of an information system into the pattern recognition model simplifies the decision-making process by reducing the number of attributes that may be missed in the decision and retaining the characteristics of the original attributes.
The Long-term Effectiveness of Sacral Neuromodulation in Treating Low Anterior Resection Syndrome: A Single Center Experience
Authors: Bisgin Tayfun , Canda Aras Emre , Manoglu Berke , Ellidokuz Hulya , Sokmen Selman
Published: February 2023

Background
Sacral neuromodulation (SNM) has emerged as an effective treatment option for patients with fecal incontinence. The efficacy of SNM in the treatment of low anterior resection syndrome (LARS) following rectal cancer surgery is encouraging. The aim of this study is to review the long-term outcomes of patients treated with SNM for LARS.
Methods
A review of a prospectively maintained database of consecutive SNM procedures for LARS between June 2017 and June 2020 was conducted. Bowel habits diaries, the Cleveland Clinic Florida-Fecal Incontinence score (CCF-FIS), the Fecal Incontinence Quality of Life Scale (FIQoL), and the LARS score were evaluated at baseline, three months, and twenty-four months after definitive SNM implantation.
Results
The study included 14 patients; 11 of them were males, and the mean age was 59.2 (±10.2). Thirteen patients underwent permanent implantation of the SNM device. The mean score of FI episodes were reduced from 16 to 4 (p < 0.001) and the mean CCF-FIS dropped from 15.2 to 6.5 (p < 0.001). All patients showed a substantial increase in their FIQoL scale (p < 0.001). Additionally, there was a significant amelioration in the LARS score (36.7 to 17.3, p < 0.001) and all symptoms of LARS except incontinence of liquid stool (p = 0.97).
Conclusions
SNM improves bowel dysfunction and quality of life in patients with LARS following rectal cancer surgery and maintains its effectiveness over time
Analysis of the effect of heavy metals on the incidence of cancer and health risk assessment on drinking water sources in 2021-2022 using geostatistics (Study area: Kohgilouye and BoyerAhmad province, Iran)
Authors: Barafrashtehpour Mansour , Ebrahim Afshin , Javad Tarrahi Mohammad , Asadi Morteza , Pourzamani Hamidreza
Published: February 2023

In this study, zoning and the effect of heavy metal concentration on the incidence of cancer, the effect of land use, the location of quifers, the assessment of carcinogenic and non-carcinogenic health risks of heavy metals for 104 drinking water sources and 1248 samples based on standard sampling methods (using It was measured by atomic absorption method equipped with graphite furnace) from drinking water sources. Then statistical indicators and spatial information system were used to compare and analyze the data. According to the obtained results, the highest concentrations of arsenic, chromium and zinc correspond to Bashet, Behmai and Cheram cities respectively (15.47 ± 10.52, 292.21 ± 312.29, 599.09 ± 320.74 micrograms per liter) Is; that the concentration of arsenic and chromium in some sources is higher than the standard. One-way analysis of variance showed that there is a significant difference between the average concentration of arsenic, chromium and zinc in the cities (P. Value < 0.05). The average health risk factor of arsenic in Bashet and Chrome in Behmai city is higher than 1. According to the results of the average cancer risk of arsenic in the drinking water sources of Basht, Gachsaran and Behmai and chromium in the water sources of Behmai and Gachsaran have a definite risk of cancer.
The roles of hospital cleaning staff in the care of infectious patients and social health during the infectious diseases disasters: a qualitative content analysis study
Authors: Ebrahimian Abbasali , Rahbar Ahmad
Published: February 2023

Background: This study aimed to explain the roles of hospital cleaning staff in caring for infectious patients and social health during infectious disease disasters.
Methods: The present study was conducted by qualitative content analysis. Participants were fifteen cleaning staff of public hospitals in Qom, Iran. Data were collected using semi-structured interviews.
Results: Data analysis led to the main theme: "Selfless efforts to help provide comprehensive patient care and disease prevention in society." This theme was derived from three main categories "helping nurses to improve the quantity and quality of basic care," "selfless service," and "helping to prevent infectious diseases in society."
Conclusions: In infectious disasters, cleaning staff provides considerable help to comprehensive patient care. They can respond to infectious disease disasters in society as a practical model of personal hygiene and adhere to health protocols. Nursing managers can use the capabilities of cleaning staff in the response phase of infectious disasters.
Electroacupuncture alleviates motor dysfunction and gut barrier damage by modulating intestinal NLRP3 inflammasome in MPTP-induced Parkinson's disease mice
Authors: Guo Lei , Hu Haiming , Jiang Nan , Yang Huabing , Sun Xiongjie , Xia Hui , Ma Jun , Liu Hongtao
Published: February 2023

Parkinson’s disease (PD) is a neurodegenerative disorder commonly accompanied by motor dysfunction. Electroacupuncture (EA) has shown anti-inflammatory and neuroprotective effects, although the potential mechanisms remain unclear. We speculated that EA could ameliorate the motor dysfunction of PD and that this would be associated with its regulatory impact on the intestinal microbiota. We applied 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to establish a PD mouse model. EA at the GV16, LR3, and ST36 acupoints was administrated for 12 consecutive days. The results of the open-field test indicated that EA alleviated depression and behavioral defects in PD mice. Further study showed that EA upregulated the expressions of tyrosine hydroxylase (TH) and brain-derived neurotrophic factor (BDNF), and blocked the accumulation of α-synuclein (α-syn) in the midbrain. Additionally, EA increased the mRNA levels of neurotrophic factors like BDNF and GDNF. Moreover, EA prevented the damage to intestinal tissues of PD mice, indicative of suppressed NLRP3 inflammasome activation and increased gut barrier integrity. Notably, the antibiotic-treated mouse experiment validated that the gut microbiota was critical in alleviating PD dyskinesia and intestinal inflammation by EA. In conclusion, our study demonstrated that EA intervention could improve PD by alleviating behavioral defects and gut barrier damage, which provides novel insights into the pathogenesis of PD and its therapy.
Leptin Signalling Promotes Axonal Regeneration in the Peripheral and Central Nervous System
Authors: Chadwick Jessica , Serger Elisabeth , Kong Guiping , Zhou Luming , Mueller Franziska , Palmisano Ilaria , Liddell Phoebe , Chu Linshan , Yan Yuyang , Giovanni Simone Di
Published: February 2023

Axonal growth is limited or absent following peripheral or central nervous system injury respectively, inhibiting repair. The identification of novel growth-promoting molecular mechanisms is therefore a priority. In the search for dietary-dependent mechanisms that control neuronal regenerative ability, we discovered that growth-promoting intermittent fasting (IF) induced leptin expression in sensory neurons of the dorsal root ganglia (DRG). Surprisingly, leptin signalling, whose canonical function is to control energy homeostasis, was found to be central to the IF-dependent regenerative phenotype. In fact, neuronal conditional deletion of the leptin receptor significantly impaired the regenerative response elicited by IF. Overexpression of leptin in vivo in DRG neurons enhanced axonal regeneration following peripheral sciatic nerve crush (SNC) and central spinal cord injury (SCI). Lastly, RNA sequencing following leptin overexpression in DRG neurons showed a significant increase in regenerative gene expression and transcription after SCI, indicating a role for leptin in inducing a euchromatic, transcriptionally active environment that facilitates nervous system repair after injury.
Demonstration of Reverse Designs based on Hand-drawn Electrical Characteristics in GaN Power Devices using Graph Attention Networks
Authors: Tseng Yi-Ming , Chen Bang-Ren , Lin Wei-Cheng , Lee Wen-Jay , Chen Nan-Yow , Wu Tian-Li
Published: February 2023

In this work, the methodology for the reserve design in GaN power MIS-HEMTs based on hand-drawn characteristics is demonstrated for the first-time using Graph Attention Network. The hand-drawn ID-VG characteristic is constructed by Ramer-Douglas-Peucker algorithm. Then, the extracted information is sent to the Graph Attention Network (GAT) to receive the corresponding device design variables, including tAlGaN, recessed depth, Al%, Lg, Lgd, and Lgs. Less than 8% of the differences in the key extracted parameters, such as Vth, Ion, and subthreshold slope (SS), can be obtained and less than 30 seconds is consumed to generate the design variables. Therefore, the developed GAT approach is promising for the reverse design of GaN power MIS-HEMTs, which can provide users with efficient and valuable design suggestions to optimize the devices toward the targeting performance.
Estimating the impact of the COVID-19 pandemic on dengue in Brazil
Authors: Roster Kirstin Oliveira , Martinelli Tiago , Connaughton Colm , Santillana Mauricio , Rodrigues Francisco
Published: February 2023

Atypical dengue prevalence was observed in 2020 in many dengue-endemic countries, including Brazil. Evidence suggests that the pandemic disrupted not only dengue dynamics due to changes in mobility patterns, but also several aspects of dengue surveillance, such as care seeking behavior, care availability, and monitoring systems. However, we lack a clear understanding of the overall impact on dengue in different parts of the country as well as the role of individual causal drivers. In this study, we estimated the gap between expected and observed dengue cases in 2020 using an interrupted time series design with forecasts from a neural network and a structural Bayesian time series model. We also decomposed the gap into the impacts of climate conditions, pandemic-induced changes in reporting, human susceptibility, and human mobility. We find that there is considerable variation across the country in both overall pandemic impact on dengue and the relative importance of individual drivers. Increased understanding of the causal mechanisms driving the 2020 dengue season helps mitigate some of the data gaps caused by the COVID-19 pandemic and is critical to developing effective public health interventions to control dengue in the future.
Functional Characterization of a missense mutation in the TRAPPC12 gene presenting with progressive encephalopathy with brain atrophy and spasticity phenotype without microcephaly and epilepsy
Authors: Yucesan Emrah , Goncu Beyza , Yesil Gozde , Aslanger Ayca Dilruba
Published: February 2023

Background
Variations in the TRAPPC12present many symptoms, including microcephaly, agenesis of corpus callosum, cerebellar atrophy, and epilepsy. These features indicate a broad range of mortality and morbidity. Identifying a variation with functional consequences provides an accurate diagnosis and proper counseling for the family. Herein, we describe the functional analysis of the homozygous missense variation NM_016030.6:c.679T>G in the TRAPPC12.
Methods
CCD1079Sk cell line (as a healthy control) and patient-derived fibroblast cells were evaluated for Golgi integrity, ER structure, and vesicle distribution and protein levels by Western blot.
Results
Protein expression showed an absence in the TRAPPC12 protein and an uncharacterized protein fragment (CGI-87). The lack of Golgi integrity and enlargement of ER structure were shown, and the vesicle distribution was even more disrupted via truncated TRAPPC12 protein. The effect of the variant resulted in milder clinical phenotype with the absence of microcephaly and epilepsy, which we had previously reported.
Conclusion
We have shown that the protein expression was disrupted, Golgi and ER structure negatively affected, resulting in a decreased and scattered number of vesicles while also having alterations in vesicle distribution. Nevertheless, these impairments did not arrest vesicle trafficking due to protein loss. However, unlike previous reports, we did not show a vesicle accumulation.
Anti-inflammatory and Ameliorative effects of two newly isolated probiotic strains in DSS-induced mouse model of colitis
Authors: Ghorbani Elnaz , Rezaei Shaghayegh , Soleimanpour Saman , Nazari Seyedeh Elnaz , Rahmani Farzad , Naimi Hamideh , Afshari Asma , Avan Amir , Ryzhikov Mikhail , Ferns Gordon , Khazaei Majid , Hassanian Seyed Mahdi
Published: February 2023

Background: Protective effects of probiotics in human diseases have been well documented in recent years. In this study, the anti-inflammatory and fibrinolytic properties of two newly isolated probiotic bacteria, Lactiplantibacillus plantarum and Lactococcus lactis either alone or in combination with standard therapy, Mesalazine (MSZ), have been investigated in a murine model for ulcerative colitis.
Methods: Characterization of newly isolated probiotic were assessed by performing antibacterial activity, antibiotic resistance, acid and bile tolerance, and hemolytic activity assays. Hematoxylin-Eosin and Masson's trichrome staining were used to evaluate inflammation and collagen deposition in colon tissue sections. Expression of inflammatory- and Fibrotic-associated genes were analyzed using Real-time PCR and ELISA assays.
Results: Results showed that administration of probiotics significantly attenuated DSS-induced colon shortening, colon weight loss, and increase in spleen weight in colitis mice. Compared to the colitis mice, disease activity index as assessed by changes in body weight, degree of stool consistency, rectal bleeding, and prolapse was decreased in probiotic-treated group. Mix of probiotics potently improved histopathological score by attenuating crypt loss, mucosal damage, and inflammation score in colitis tissues. Consistently, mRNA and protein levels of pro-inflammatory genes as well as oxidative stress markers were suppressed in the presence of probiotics in colon tissues. Furthermore, probiotic bacteria reduced fibrosis by down-regulating pro-fibrotic genes including Col 1a1 and α-SMA in colon tissue homogenates.
Conclusion: These results showed that mix of these newly isolated probiotic bacteria is as potent as the standard treatment and could be utilize as a novel therapy for ulcerative colitis without any observed side effects. Future experiments on these probiotics in other models of UC is needed to completely address the efficacy potency and safety concerns.
The Quagmire Model: How a small step can trap you in the quagmire of misinformation, hate speech and denialism
Authors: Camilo-Da-Silva Eduardo , Barbedo Claudio Henrique Silveira , Marins Eugenio Rangel , Santini Rose Marie , Castro Joel Pereira
Published: February 2023

This study aims to explain how social media (SM) users, whilst searching for information, can be trapped into a quagmire of misinformation, even when they have no denialist inclinations or sympathy for hate groups. We analyze the interactions between cognitive biases and deep preference learning algorithms (DPL), as SM companies use DPL to curate the content conveyed to its users. The study proposes a model for users’ behavior and explain how SM business model allows new information to be introduced in the quagmire in order to change user’s opinions in a way desired by a customer willing to pay for, and, eventually, accomplished it. The model explains why some popular tactics against misinformation, as censorship and fact-checking, achieve very poor results. We suggest that policies promoting face-to-face encounters in friendly environments can be more effective in that struggle. We believe the model can help decision makers in developing more efficient anti-disinformation policies.
Design and Development of Insole Using Carbon Fiber For Partial Foot Amputation
Authors: Wagle Chandrika , Padhi S. N.
Published: February 2023

One recommended gait rehabilitation treatment after stroke is using ankle and foot orthotics. In clinical practice, it is essential to adjust the torque of the ankle-foot orthosis assistance to suit each patient’s body function and gait ability. The present study investigated the effect of changing the plantar flexion resistance of the ankle–foot orthosis on the post-stroke gait kinematics and kinetics during the early stance phase using a musculoskeletal model and an ankle–foot orthosis model. A prosthetic foot plate is designed, analyzed, and validates with the experiment work accomplished in this paper. A finite element (FE) model of the human foot was developed from 3D printing of 2 mm thick UK7 size. The finite element predictions are being validated theoretically and experimentally.
sympatric voltinetypes and their response to climate warming in Asian corn borer
Authors: Wang Lianxia , Liu Kaiqiang , Zhao Xiumei , Zhang Tiantao , Yuan Ming , He Kanglai
Published: February 2023

Voltinism in facultative diapause insect can be shift by temperature and photoperiod. Climate warming could drive individuals that used to be univoltinism shift to bivoltinism due to compensatory effect of elevated temperature. Asian corn borer (ACB) is a notorious pest on corn in China, for investigating the voltinism of Asian corn borer in Qiqihar and assess the possible role of thermal-dependent phenological plasticity on voltinism and population dynamics under the scenario of global warming. Voltinism plasticity was assessed in field trials with screen cages and moth flight was investigated with light trap catch data from 2016 to 2021 corn growing seasons. Furthermore, we incorporated these data to constructed a comprehensive model of the temporal dynamics of ACB and explored the behavior of this model over the course of 2016 to 2021climate scenario in Qiqihar, Heilongjiang Province, China. There were 51.3–62.8% of the population performing bivoltinism, whereas others were univoltinism. Bivoltinism could be influenced by the accumulated degree-days after 8 July since then the photoperiod is shortening from critical daylength. The model predicted mostly two full generations (82.4–92.5%) in warmer years (2016 and 2018) based on bivoltine individual emergence dates, but it would decline to 49.7–63.8% in cooler years (2019–2021). Due to generation overlap, a partial third generation is hardly unpredictable. These results revealed co-existence of uni-, bi- and multi-voltinetypes in ACB population. Higher thermal accumulation due to ongoing climate warming scenario could further insect phenology and speed completion of insect life-cycle, which will let to higher proportion of bivoltinism and even trivoltinism.