bluuebunny/crossref_metadata_2025 huggingface dataset:
An Integrated RME and PBL Mathematics E-Module for Vocational High School Learning: A Need Analysis
Authors: Hayuni Argenti Agung , Murtiyasa Budi , Setyaningsih Nining
Published: January 2025

In this digital era, we can access information that we need easily. Including mathematics learning material. The are a lot if digital based learning materials that can be accessed anytime anywhere. However, the are still limited studies about developing mathematics e-modul as one of learning resources for vocational high school students. Therefore, this study investigates the need to develop An Integrated RME and PBL Mathematics E-Module for Vocational High School learning. This study is a descriptive survey involving 52 tenth grade students consist of 27 students from the Pharmaceutical Technology Expertise Field, 10 students from the Industrial Chemical Engineering Expertise Field, and 15 students from the Beauty and Spa Expertise Field, and also four mathematics teachers from four different vocational high schools with various expertise field in a city of Surakarta, Central Java, Indonesia. The data collection was conducted using printed questionnaires (for students) and online questionnaires (for teachers). The data was summarized and analyzed descriptively. Based on the data analysis, it can be concluded that there are still limited realistic problems in Indonesian mathematics textbook for vocational high school based on each expertise fields. Therefore, developing an integrated RME and PBL mathematics e-module is necessary. The characteristic of the integrated RME and PBL mathematics e-module are: (1) the e-module’s content should be presented in Bahasa Indonesia, providing realistic contexts by the certain expertise field and can also be from various expertise fields; (2) the learning activities should be carried out in groups, held inside or outside the classroom and involve problems that are related to the expertise field; (3) the learning media can be in the form of electronic and non-electronic media; (4) The assessment activities can be carried out in writing or authentic assessment.
The Impact of augmented reality media integrated with ethnomathematics on students' numeracy literacy skills
Authors: Pasaribu Rotua Saulina , Husna Asmaul , Hanggara Yudhi
Published: January 2025

The problem of students' numeracy literacy is a major concern in mathematics education. This study aims to explore the impact of the application of Augmented Reality (AR) media integrated with Limas Potong traditional house on students' numeracy literacy skills. The research method used was pre-experimental with one class group as the research subject. A total of 22 students of class VIII F MTs USB Filial MTsN 1 Batam became research subjects. The instrument used was an essay-shaped test to measure numeracy literacy which was adjusted to the material taught. Data analysis was carried out by parametric one tailed sample t-test after ensuring normal data distribution. The results showed that the use of AR media integrated with the Limas Potong traditional house had a positive impact on improving students' numeracy literacy skills. The integration of AR media allows students to experience firsthand the structure and characteristics of the traditional house, thus making math learning more interesting. This research contributes to the development of innovative and interesting mathematics learning methods through the use of Augmented Reality media in the context of Indonesian traditional houses.
Analysis of the role of the merdeka Mengajar Platform in teacher self-development at SDN 7 Suwawal
Authors: Latif Sinta Norlaela , Zumrotun Erna , Attalina Syailin Nichla Choirin
Published: January 2025

Merdeka Mengajar Platform (PMM) is an application that empowers teachers at SDN 7 Suwawal, supports self-development, and maximizes students' potential. Teachers are expected to master four main competencies: pedagogical, personality, social, and professional. PMM facilitates increasing competency through independent training, references, and understanding of the Merdeka Curriculum. This research aims to analyze the role of PMM in teacher self-development at SDN 7 Suwawal, its impact on teaching performance, and the obstacles faced. The method used is qualitative with case studies, collecting data through in-depth interviews, observation, and documentation from three teachers (classes I, III, VI) in the second semester of the 2024-2025 academic year. The results of interviews and observations are strengthened by documentation of real action certificates, which show concrete results from the use of PMM in teacher self-development. Class I teachers actively access PMM and participate in discussions even though they have not yet received a certificate. Class III teachers earned one certificate, while class VI teachers earned four certificates, demonstrating commitment and perseverance. The research results show that PMM helps in independent training, increasing competence, and implementing differentiated learning. Although the main obstacle is poor signal network quality, PMM has a positive impact on teachers' teaching performance, improves the quality of learning, and supports continuous professional development. By providing access to independent training, supporting a variety of teaching methods, and offering a platform for collaboration and workshops, PMM contributes significantly to improving the quality of education at SDN 7 Suwawal.
ANALISIS PENGARUH GAYA KEPEMIMPINAN, TINGKAT PENDIDIKAN, PELATIHAN DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PADA PT. CITRA LAUTAN TEDUH
Authors: Tanjung Rona , Budiyanto Budiyanto , Suhermin Suhermin , Imelda Imelda , Saputri Yulita , Hakim Buyung Nul , Pinayungan Doni , Purba Moden , Ardi Nadia Khaira , Sutjahjo Gandhi
Published: January 2025

PT. Citra Lautan Teduh bergerak pada bidang manufaktur khususnya memproduksi Tiang Pancang Beton Putar pra tekan atau pre-tensioned spun concrete pile. Kinerja karyawan yang berkualitas ialah kinerja yang sama dengan standar perusahaan dan bisa membantu untuk mencapai tujuan perusahaan, dengan ini perlu didukung oleh beberapa faktor yaitu contohnya gaya kepemimpinan, tingkat pendidikan, pelatihan dan disiplin kerja. Populasi pada penelitian ini berjumlah 90 orang karyawan tetap dan sampel yang digunakan yaitu 90 orang karyawan tetap dengan menggunakan teknik sampel jenuh. Hasil dari uji f diperoleh nilai f hitung sebesar 55,926, nilai f tabel sebesar 2,48 artinya nilai f hitung lebih besar dan nilai signifikan sebesar 0.000 < 0,05 sehingga bisa disimpulkan Gaya Kepemimpinan (X1), Tingkat Pendidikan (X2), Pelatihan (X3) dan Disiplin Kerja secara bersama-sama berpengaruh signifikan terhadap Kinerja Karyawan (Y).
FAKTOR YANG MEMPENGARUHI PEMILIHAN KARIR SEBAGAI AUDITOR EKSTERNAL PADA MAHASISWA AKUNTANSI
Authors: Sari Rizki Yuli , Yusyawiru Nurul , Pratiwi Mirza Ayunda , Satria Mohd Rhana , Wulandari Kiki
Published: January 2025

Tujuan penelitian ini adalah untuk menganalisis dan menjelaskan Faktor Yang Mempengaruhi Pemilihan Karir Sebagai Auditor Eksternal Pada Mahasiswa Akuntansi Universitas Maritim Raja Ali Haji dengan menggunakan teknik analisis regresi berganda. Pengumpulan data pada penelitian ini menggunakan kuesioner dengan googleform. Populasi pada penelitian ini adalah mahasiswa akuntansi pada universitas maritim raja ali haji yang telah menyelesaikan mata kuliah pengantar auditing, auditing dan/atau praktek audit. Metode Analaisis data dengan menggunakan software SPSS versi 26. Jumlah responden yang mengisi kuesioner sebanyak 52 Mahasiswa. Hasil analisis menunjukkan bahwa Penghargaan Finansial, Lingkungan Sekitar, Pengetahuan tentang Auditor Eksternal dan Pertimbangan Pasar Kinerja secara bersama-sama/secara simultan berpengaruh signifikan terhadap Pilihan Karir sebagai Auditor Eksternal.
ESTIMATING THE PERFORMANCE OF THE GAKKUMDU IN HANDLING REPORTS AND FINDINGS OF VIOLATIONS OF THE 2024 ELECTIONS
Authors: Nurhayati Dwi Astuti Wahyu
Published: January 2025

: It is imperative that vulnerabilities in the 2024 election law enforcement system be identified in order to provide learning and development for election organisers and other law enforcement organisations. This study aims to comprehend the kinds of cases that remain unresolved, the actions that are taken, the opinions of GAKKUMDU, about the receipt of reports and violations, the challenges encountered in managing and resolving issues, and the perspectives that the public will have going forward regarding election dispute resolution. Using a juridical-normative approach, the research uses normative legal research methodologies to analyse the relevant legal norms in the context of addressing election-related criminal offences in 2024.The results show two different types of reports: one was registered and included the village heads' lack of neutrality, while the other four were not (distribution of staple food packages, damage to campaign media (APK and APS), lack of transparency by the Election Supervisory Body, and circulation of the "Tabloid Indonesia Maju". Several steps were taken by GAKKUMDU in handling reports and violations included harmonising perceptions is the result of the actions conducted, which include beginning harmonisation, receiving reports, managing violations, monitoring, and evaluation. Assessing the Gakkumdu Center's efficiency in addressing electoral infractions in 2024 and aligning perceptions entails coordinating the opinions, strategies, and tactics of the several stakeholders engaged in election law enforcement are obligation to conduct. It is intended that by comprehending the current problems, practical measures to strengthen accountability, better the election law enforcement process, and guarantee a more equitable and transparent election can be found. The collaboration is not only done by Bawaslu, the Police, or the Prosecutor's Office but also in order to manage the election offences of 2024.
FROM BOODLINES TO BALLOTS: THE INTERSECTION OF FAMILY POWER AND WOMEN POLITICAL ELECTABILITY
Authors: Anisyah Siti , Harahap Raegen
Published: January 2025

The discourse women's representation in politics has gained traction globally, including in Indonesia. While the progress made by women in the political arena deserves recognition, especially in a society where gender Stereotypes and patriarchal norms remain deeply rooted, it is crucial to acknowledge that many women still struggle to contest elections independently without relying on factors such as political dynasties, financial resources, incumbency, or family connections. This article delves into the significant role of family ties in shaping the electability of women in politics, with a specific focus on Zainab’s successful bid in the 2019 legislative election for Electora District V, Ogan Ilir Regency. Using a qualitative-descriptive research method and a library research approach, this article explores how Zainab's victory is closely linked to the influence of her family's prominent status, which is known as a respected and generous family with extensive networks among community leaders in various villages. We foud that Zainab’s family played a crucial role in crafting a positive public image, boosting her popularity, and ultimately securing her electability, despite her status as a newcomer in the political landscape of Ogan Ilir. The findings underscore the importance of family legacy as a powerful political asset, highlighting how the strength of a family name can be a decisive factor in political success, as evidenced by Zainab’s victory in the 2019 election in Ogan Ilir Regency.
PENGARUH KOMPETENSI SUMBER DAYA MANUSIA DAN SISTEM INFORMASI PEMERINTAH DAERAH (SIPD) TERHADAP KUALITAS LAPORAN KEUANGAN
Authors: Siregar Renta Herawaty Roito , - Nurlinda , Indahwati Rini
Published: January 2025

Tujuan pernerlirtiran irnir adalah untuk merngertahuir bagairmana perngaruh perran komperternsir sumberr daya manusira dan pernerrapan sirsterm irnformasir permerrirntah daerrah terrhadap kualirtas laporan keruangan dir permerrirntah Kota Sirbolga. Pernerlirtiran irnir dirlakukan pada Organirsasir Perrangkat Daerrah Permerrirntah Kota Sirbolga. Mertoder pernerlirtiran yang dirgunakan dalam pernerlirtiran irnir adalah mertoder pernerlirtiran kuantirtatirf derngan mernggunakan pernderkatan derskrirptirf dan verrirfirkatirf. Terknirk perngambirlan samperl yang dirgunakan dalam pernerlirtiran irnir adalah probablirlirty samplirng yaknir 37 Organirsasir Perrangkat Daerrah Kota Sirbolga. Populasir targert pernerlirtiran adalah Kasubbag Perrerncanaan dan atau Keruangan, Staf Pernatausahaan Keruangan dan Berndahara Perngerluaran dir masirng-masirng Perrangkat Daerrah, serhirngga jumlah samperl mernjadir 74 rerspondern. Mertoder perngumpulan data dirlakukan derngan kuersironerr. analirsirs rergrersir berrganda derngan mernggunakan program SPSS verrsir 22. Hasirl pernerlirtiran mernunjukkan bahwa komperternsir sumberr daya manusira dan pernerrapan sirsterm irnformasir permerrirntah daerrah berrperngaruh posirtirf terrhadap kualirtas laporan keruangan permerrirntah kota Sirbolga.
IMPLEMENTASI BLOCKCHAIN DENGAN MENINGKATKAN TRANSPARASI DAN KEAMANAN LAPORAN KEUANGAN GLOBAL DALAM AKUNTANSI INTERNASIONAL
Authors: Khair Herla Shabahal , Admar Ok Agam , Mar'atussoliha Mar'atussoliha Mar'atussoliha , Nurlaila Nurlaila Nurlaila
Published: January 2025

Penelitian ini bertujuan untuk menganalisis implementasi teknologi blockchain dalam konteks akuntansi internasional, dengan fokus utama pada peningkatan transparansi dan keamanan laporan keuangan global. Blockchain, sebagai teknologi terdesentralisasi yang menekankan transparansi serta keamanan data, diharapkan dapat mengatasi berbagai kelemahan yang ada dalam sistem pelaporan keuangan tradisional, termasuk masalah manipulasi data dan ketidakakuratan laporan. Metode penelitian yang digunakan adalah pendekatan kualitatif, dengan studi literatur dan analisis komparatif dari berbagai studi kasus penerapan blockchain dalam pelaporan keuangan di perusahaan multinasional. Data dikumpulkan dari sumber-sumber seperti jurnal akademik, laporan audit, serta wawancara dengan para ahli di bidang teknologi dan akuntansi internasional. Analisis data dilakukan dengan teknik coding tematik, yang membantu dalam mengidentifikasi pola dan tren dalam implementasi blockchain di sektor keuangan global. Hasil penelitian menunjukkan bahwa blockchain dapat meningkatkan transparansi dengan menyediakan sistem yang lebih mudah diaudit dan dilacak, sementara keamanan data laporan keuangan juga meningkat berkat mekanisme kriptografi. Meski demikian, tantangan utama mencakup adopsi teknologi ini di berbagai yurisdiksi serta penyelarasan standar akuntansi internasional, seperti IFRS dan US GAAP.
TANGGUNG JAWAB SOSIAL PERUSAHAAN: TELAAH FINANSIAL PADA SEKTOR BASIC MATERIALS
Authors: Margono Tiara Pramudya Wardani , Sari Shinta Permata
Published: January 2025

Abstract
The implementation of corporate social responsibility is absolutely necessary for companies engaged in the basic materials sector. By reporting corporate social responsibility, the company's image will be increasingly directed towards a better direction. The purpose of this study is to test and analyze the effect of leverage, company size and profitability on the disclosure of corporate social responsibility. The data used in this study are secondary data in the form of annual reports or sustainability reports of basic materials sector companies for the period 2021-2023 obtained from the Indonesia Stock Exchange website or the official pages of basic materials sector companies.
This research was conducted in the form of quantitative research using purposive sampling techniques. Of the 102 companies, 37 companies were selected based on predetermined criteria.
The results of the analysis show that leverage and company size affect the disclosure of corporate social responsibility, while profitability does not affect the disclosure of corporate social responsibility.

Keywords: corporate social responsibility, leverage, company size, profitability.

Abstrak
Implementasi tanggungjawab sosial perusahaan mutlak diperlukan pada perusahaan yang bergerak di sektor bahan dasar (basic materials). Dengan melakukan pelaporan tanggungjawab sosial perusahaan, citra perusahaan akan semakin terarah ke arah yang lebih baik. Tujuan dari penelitian ini adalah untuk menguji dan menganalisis pengaruh ungkitan, ukuran perusahaan dan kemampulabaan terhadap pengungkapan tanggungjawab sosial perusahaan. Data yang digunakan dalam penelitian ini adalah data sekunder berupa laporan tahunan atau laporan keberlanjutan perusahaan sektor bahan dasar (basic materials) periode 2021-2023 yang diperoleh dari situs Bursa Efek Indonesia atau laman resmi perusahaan sektor bahan dasar (basic materials). Penelitian ini dilakukan dalam bentuk penelitian kuantitatif dengan menggunakan teknik purposive sampling. Dari 102 perusahaan, terpilih 37 perusahaan berdasarkan kriteria yang telah ditentukan. Hasil analisis menunjukkan bahwa ungkitan dan ukuran perusahaan berpengaruh terhadap pengungkapan tanggungjawab sosial perusahaan, sedangkan kemampulabaan tidak berpengaruh terhadap pengungkapan tanggungjawab sosial perusahaan.

Kata Kunci: tanggungjawab sosial perusahaan, ungkitan, ukuran perusahaan, kemampulabaan.
PENGARUH PENGETAHUAN PERPAJAKAN, KESADARAN WAJIB PAJAK, SISTEM E-SAMSAT DAN INSENTIF PAJAK TERHADAP KEPATUHAN PEMBAYARAN PAJAK KENDARAAN BERMOTOR DI KABUPATEN KLATEN
Authors: Mahapsari Mardina Mey , Yustrianthe Rahmawati Hann , Purwantini Maria , Asmarawati Budi
Published: January 2025

This study aims to determine the effect of tax knowledge, taxpayer awareness, E-samsat system, tax incentives on compliance with motor vehicle tax payments in Klaten Regency. The population used in this study were taxpayers in Klaten Regency. The sample selection in this study used the Purposive Sampling method and obtained a sample of 100 respondents. The data analysis technique used multiple linear regression analysis. The results of the study showed that tax knowledge and taxpayer awareness had an effect on taxpayer compliance, while the e-samsat system and tax incentives did not have an effect on taxpayer compliance.
PENGARUH LITERASI KEUANGAN, PENDAPATAN, KONTROL DIRI, GAYA HIDUP DAN INTENSITAS PENGGUNA MEDIA SOSIAL TERHADAP PERILAKU KONSUMTIF PENGGUNA SHOPEE PADA MAHASISWA UNIVERSITAS RIAU KEPULAUAN
Authors: Ukhriyawati Catur Fatchu , Muharam Muharam , Putra Rizki Eka , Mulyati Sri , Hati Ravika Permata
Published: January 2025

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh Literasi keuangan, pendapatan, kontrol diri, gaya hidup dan intensitas pengguna media sosial terhadap Perilaku konsumtif pengguna shopee pada mahasiswa Universitas Riau Kepulauan . Penelitian ini merupakan penelitian kuantitatif dengan pendekatan populasi penelitian adalah mahasiswa Universitas Riau Kepulauan 3122 mahasiswa dengan penarikan sample berdasarkan metode random sampling menggunakan rumus slovin berjumlah 355 orang responden. Data dikumpulkan melalui kuesioner dengan teknik skala Likert dan dianalisis menggunakan regresi linier berganda. Hasil penelitian menunjukan bahwa literasi keuangan, pendapatan, kontrol diri, gaya hidup dan intensitas pengguna media sosial secara simultasn berpengaruh signifikan terhadap perilaku konsumtif pengguna shopee pada mahasiswa Universitas Riau Kepulauan ( F hitung 112.480 > F tabel 2.24, signifikan 0.000 < 0,05 ). Secara parsial, setiap variabel independen ( literasi keuangan, pendapatan, kontrol diri, gaya hidup dan intensitas pengguna media sosial ) juga berpengaruh positif dan signifikan terhadap perilaku konsumtif dengan koefisien korelasi (R) sebesar 0,786 menunjukan hubungan positif antara variabel independen dengan variabel dependen. Nilai adjusted R2 sebesar 0,612 berarti 61,2% terhadap perilaku konsumtif pengguna shopee sedangkan 38,8% dipengaruhi variabel lain diluar variabel independen yang tidak diteliti pada penelitian ini. Sedangkan untuk nilai korelais ( R ) 0,786 yang berarti hubungan antara variabel Literasi keuangan, Pendapatan, Kontrol Diri, Gaya Hidup dan Intensitas Pengguna Media Sosial terhadap Perilaku Konsumtif pengguna shopee pada mahasiswa Universitas Riau Kepulauan sebesar 78,6% artinya hubungan yang dimiliki Erat.
Tarantula Toxin Transcripts and Toxin Structure Prediction by AlphaFold
Authors: Vega Christine , Sepulveda Rebekkah , Jia Ying
Published: January 2025

Tarantula venom predominantly comprises peptides and small proteins (venom toxins). To explore this further, we generated a combined gland cDNA library from five different tarantula species. Subsequently we randomly sequenced 752 clones, which led to the identification of sixteen distinct toxin groups, including one novel group. Each group consists of a minimum of three identical sequences. A comprehensive analysis of these toxin groups was carried out, and we simulated the 3D structures of certain predicted toxins. These transcripts can be used to the production of venom toxins through recombinant techniques, offering promising applications in various biomedical applications.
Synthesis, Structural Characterization and In Vitro Leishmanicide and Antifungal Activities Studies of Schiff Base Compounds
Authors: Jean-Baptiste Kangah Niameke , Tieba Tuo Nanou , Edwige Ziale Djele Alette , Claude Kablan Ahmont Landry , Guillaume Kodjo Charles , Nahosse Ziao
Published: January 2025

N, N'-bis (2-nitrophenyl methylene)hexane-1,6-diamine, N, N'-bis (4- nitrophenylmethylene)benzene-1,3-diamine, N, N'-bis (p-nitrophenylmethylene) cyclohexane- 1,2-diamine were synthesize and have been characterized by conventional spectrometry methods (NMR, IR and HR-ESI-MS). Antileishmanicide and antifungal screening showed that, N, N'-bis (2-nitrophenyl methylene) hexane- 1,6-diamine, with MIC of 16.40 mg/L and 125 mg /L respectively, is the most active.
Central Hyperthyroidism Revealing A Thyrotropic Pituitary Adenoma In An Internal Medicine Unit: A Case Report
Authors: Mansour Diallo Bachir , Thiam Abo Ibrahima Hady , Ndour Jean Noel , Sow Faye Fulgence Aboubacry , Baba Nana Mamoudou , Yanidou Ndiaye , Adama Wade , Khadr Mbaye Serigne Abdou , Adama Berthé , Souleymane Touré Papa , Magatte Diop Madoky , Mourtalla Ka Mamadou
Published: January 2025

Introduction: TSH adenoma is the rarest cause of hyperthyroidism. We report the case of a 22-year-old female patient followed for hyperthyroidism revealing a TSH adenoma.

Case Observation: A 22-year-old female patient with no previous history presented a thyrotoxicosis syndrome with no amenorrhea, no galactorrhea or amenorrhea or recent weight gain. She experienced no dizziness, headaches or vomiting. Biological investigations were normal except for TSH or thyrotropin, which was elevated, associated with an increase tetraiodothyronine. A magnetic resonance imaging revealed a pituitary adenoma. Further investigation of other hormonal axes came back normal. The patient was put on carbimazole (40mg/day), propranolol and anxiolytics. A neurosurgical opinion was requested. We observed a good clinical evolution with regression of signs of thyrotoxicosis.

Conclusion: TSH pituitary adenoma is a pathology that is rarely described in the literature. Its treatment requires good coordination between surgeons and internists or endocrinologists.
Safety and Long-Term Efficacy of Pembrolizumab Plus a Personal Dendritic Cell Vaccine in a Patient with Metastatic Melanoma
Authors: S Nangia Chaitali , L Lopez Katrina , O Dillman Robert
Published: January 2025

Background: Monoclonal antibodies that target programmed-death molecule-1 (anti-PD-1) are an effective immunotherapy for advanced melanoma. A promising investigational approach is a patient-specific therapeutic vaccine consisting of autologous dendritic cells pulsed with autologous tumor antigens from autologous tumor cells that are self-renewing in tissue culture. There is a strong rationale for combining these two immunotherapy approaches.

Patient and Methods: A 72-year-old White female was diagnosed with stage IVb metastatic melanoma confirmed by biopsies of lung and soft-tissue nodules. A short-term cell line was established from a 1.6 cm lung nodule. Autologous dendritic cells were differentiated from autologous monocytes obtained via leukapheresis. Per protocol, treatment was initiated with intravenous pembrolizumab every three weeks while the personal vaccine was manufactured. During the next 24 weeks, she received eight subcutaneous vaccine injections and eight more pembrolizumab infusions. After completing concurrent therapy, she continued pembrolizumab for an additional 27 months before stopping because of post-injection pruritus.

Results: Treatment was well-tolerated, both during the nine weeks of single-agent pembrolizumab as well as during the six months of concurrent immunotherapy. Just before starting the combined therapy, radiologic tests confirmed an objective partial response. Subsequently, her measurable disease continued to improve with SUV intensity decreased on PET scans and tumor size decreased on CT scans. One year after completing the vaccine, PET/CT scans were interpreted as showing a complete remission which was still ongoing 30 months later, 3.5 years after the initial diagnosis.

Conclusions: This personalized combination immunotherapy treatment is encouraging based on the lack of toxicity, confirmation of anti-tumor efficacy, and observed long-term disease control. Additional investigation of this combination is warranted.
Normosmic Hypogonadotropic Hypogonadism, Pituitary Hypoplasia, and Testicular Microlithiasis as Presentation of 45XY Robertsonian Translocation
Authors: Baghdasaryan Eric , Turner Robert , Abnous Osheen , Valles-Ayoub Yadira , Robinson Michael
Published: January 2025

Male hypogonadism is characterized by the failure of the testes to produce normal levels of testosterone, sperm, or both. It can manifest as either primary hypogonadism (testicular dysfunction) or secondary hypogonadism (hypothalamic pituitary dysfunction). Testosterone is critical for the development of male physical characteristics and plays an essential role in maintaining muscle mass, bone density, sexual function, and overall mood and energy levels. Hypogonadism, either primary or secondary, can present in various stages of life with different associated symptoms. Most commonly prepubertal age males present with delayed puberty, whereas adult males present with symptoms of decreased libido, erectile dysfunction, fatigue, overall lack of energy and infertility. This report describes a case of hypogonadotropic hypogonadism, testicular microlithiasis, and pituitary hypoplasia associated with a 13;14 Robertsonian translocation, an uncommon and incompletely understood etiology of hormonal dysfunction and infertility.
Effect of a LINE 1 DNA Sequence on Expression of Long Human Genes
Authors: Brown Jay C
Published: January 2025

Although LINE1 DNA sequence elements are well known for their ability to replicate and move autonomously within the human genome, these features are observed in only a small proportion (0.02%) of the total human LINE1 population. Nearly all of the total ~500,000 LINE1 elements are fragments of full-length LINE1 and are inactive for autonomous replication or movement. Truncated, inactive LINE1 sequences are found throughout the human genome including within the body of protein-coding genes, and this intragenic population is the subject of the study described here. The goal was to extend what is known about the properties of intragenic LINE1 sequences. The study was carried out with t1519, a truncated LINE1 sequence composed of the 3’ terminal ~1500 bp of the ~6000 bp full length LINE1 element, and with the sequences of three human chromosomes 16, 17 and 18, that are rich in t1519 sequences. NCBI BLAST was used to identify t1519-containing genes in each chromosome, and the length and expression level of those genes was compared with control genes lacking t1519. A striking result was observed in the case of long protein-coding genes, genes longer than 140 kb. All had one or more t1519 sequences in the gene body, all in introns. An effect on the level of gene expression was also observed. Low expression (<50 TPM) was found in all long, t1519 positive genes while much higher levels (500-600 TPM) were found with genes in the common length range (>< 140 kb) regardless of the presence of t1519. Similar results were obtained when lncRNA genes were studied instead of protein-coding ones. The results are interpreted to support a strong suppressive effect of t1519 on expression of long protein coding genes and also on certain lncRNA genes. It is suggested that the suppressive effect is due to a need for the cell to limit the overall level of transcription it can support.
Facial Suspension and Reconstruction of the Nasolabial Fold with the Use of Local Dermal-Fat Flap
Authors: Feitosa Roney Goncalves Fechine , de Araujo Rafael Silva , Valerio Camila Cristina , Waisberg Flavia Modelli Vianna , Ching An Wan , Ferreira Lydia Masako
Published: January 2025

Treatment techniques for facial paralysis have evolved significantly over the past few decades, offering a variety of options to improve facial symmetry and muscle function. The purpose of this paper is to introduce a novel static treatment technique for the surface of the nasolabial fold (NLF) in patients with chronic facial nerve paralysis, aged between 40 and 80 years, who are not candidates for dynamic rehabilitation and present with NLF erasure. The surgical marking process was initiated by determining the projection of the nasolabial fold on the paralyzed side, through measurement of the NLF on the non-paralyzed side. Subsequently, a line was drawn around the nasal ala, and a second line was demarcated in the medial region of the sulcus. In the region close to the nasal ala, along this second line, a notch was planned. The procedure was conducted under local anesthesia. In this study, four procedures were performed without any complications. Comparatively, the outcomes demonstrated an improvement in facial symmetry, the creation of a new NLF, elevation of the ipsilateral lip commissure, and correction of nasal deviation. The proposed technique is straightforward, reproducible, and can be performed in an outpatient setting.
Metronidazole Plus Omeprazole-Induced Cachexia in a Postmenopausal Woman: A Case Report
Authors: Mwanakasale Victor , Balapala Karthek , Mwila Mwaba H , Kalolekesha Memory C
Published: January 2025

We present an unusual case of a postmenopausal woman that developed near death Cachexia as a side effect to prolonged course of a combination of drugs to treat her Peptic ulcer Disease. Withdrawal of the responsible drugs led to resolution of the Cachexia. We emphasize the importance of either the physician or the pharmacist giving clear instructions to elderly patients on how to take the prescribed medication to avoid a catastrophe.
CREB and AKT Levels Higher in Attention Deficit Disorder (ADD) Individuals
Authors: AJ Russo , Dy Brianna A , Drown Jacqueline A , Mensah Albert , Lukasik James , Bowman Judith
Published: January 2025

Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric neurodevelopmental disorder in children and adolescents. CREB (cAMP response element-binding protein) is a cellular transcription factor, which plays a role in neuronal plasticity and long-term memory formation in the brain. Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes. In this study we used ELISAs to measure CREB and Akt levels in patients with ADD and found CREB levels to be significantly higher in the ADD group and the levels in individuals correlate significantly with significantly higher AKT levels we found in the same patients in a previous study.
Flat oysters Ostrea edulis are not susceptible to Marteilia pararefringens infection
Authors: Bøgwald M , Skår C , Mortensen S
Published: January 2025

The host specificity of Marteilia pararefringens is under discussion after its suggested reseparation from the flat oyster pathogen M. refringens in 2018. In Norway, M. pararefringens has been detected in mussels Mytilus spp. sampled from several isolated, small heliothermic ponds (polls) that, at least on the western coast, inhabit some of the last reproducing flat oyster populations. M. refringens has never been detected in Norway. The polls have a limited water exchange, and their uniquely warm temperature can result in high M. pararefringens prevalence and infection intensities, representing unique sites to study the susceptibility of flat oysters to this parasite. We have sampled flat oysters and mussels from all known M. pararefringens sites along the Norwegian coast. All flat oysters and mussels were screened by histology and PCR. Furthermore, to study the potential effect of natural resistance breeding of local flat oysters subjected to repetetive M. pararefringens cycles, we deployed naïve flat oysters from a known Marteilia-free poll to Agapollen, where the parasite has had consistent infection cycles since its discovery in 2016. Naïve mussels were deployed simultaneously in 2 separate years to verify that the flat oysters were subjected to at least 2 transmission cycles. M. pararefringens was not detected in any flat oysters in any poll, local or naïve, despite presence in the mussel populations. Our results show that the European flat oyster Ostrea edulis is not a susceptible host for M. pararefringens.
COMPETITIVENESS OF SOCIAL ENTERPRISES IN SLOVAKIA: THE STRUGGLE FOR CONTRACTS IN PUBLIC PROCUREMENT
Authors: HADAČOVÁ DANIELA , MALIČKÁ LENKA
Published: January 2025

This paper examines public procurement contracts on the e-contracting portal (EKS) in Slovakia from September 2014 to January 2023, analysing 160,387 contracts. Social enterprises participated in 1,642 bids, representing 0.44% of unique bidders, with a notable success rate of 33.13% for contracts they contested. Financial allocations to social enterprises remained below 1% across all reviewed periods. The analysis reveals that social enterprises primarily engage in service-oriented contracts, while commercial suppliers focus on specialized goods. Using machine learning methods and logistic regression, the key determinants of success for social enterprises are identified. They include the number of bidders and submitted bids, bid type, and short-term bank loan value. These findings provide insights into the role of social enterprises in public procurement and inform strategies to enhance their participation.
APPLICATION OF THE THEORY OF CONSTRAINTS IN THE SERVICE SECTOR
Authors: CHAMRADA DANIEL , CHYTILOVÁ EKATERINA
Published: January 2025

Innovations involve changes to strengthen the company’s position in hugely competitive markets. McDonald’s food chain has always sought to implement the Theory of Constraints (ToC), detecting global weak points to work on. This innovative approach comprises facilitating and cost reduction of production processes or expanding business services. In the article, we evaluate the impact of these innovations using the linear regression method in the McDonald's food chain in Czechia between 2007 and 2020. Our results show that the McCafé and McDelivery services are the most profitable businesses for the expansion of business activities, services and distribution channels. By following successful business models, the food chain reacts intelligently to new market trends in this global competition. Our findings agree with the further pursuit of ventures for expanding business activities.
ENHANCING FIRST-YEAR UNDERGRADUATE STUDENTS' ADAPTATION THROUGH PERSON-CENTRED THINKING
Authors: ŠOLCOVÁ JANA , ŠEBEN ZAŤKOVÁ TÍMEA , TOKOVSKÁ MIROSLAVA
Published: January 2025

This study uses person-centred thinking as a theoretical framework to explore first-year undergraduate students' adaptation preferences. The aim is to enhance understanding of support mechanisms by analyzing students' subjective experiences. A qualitative visual methodology employing "one-page profiles" was used to identify preferences for improving adaptation. The research involved 18 students from humanities programs at two Slovak universities. Semiotic analysis of visual representations and thematic analysis of text revealed key preference areas: values, personality traits, social aspects, and motivation. Findings highlight a preference for a holistic approach combining personal development, social support, and academic growth, emphasizing authentic communication and empathetic understanding.
ACCIDENT RATE OF THE INTEGRATED RESCUE SYSTEM IN THE KARLOVY VARY REGION IN 2011-2022
Authors: BÖHM PAVEL , BERKOVSKÁ TEREZA
Published: January 2025

The study analyzes the frequency and causes of traffic accidents involving vehicles of the Integrated Rescue System (IRS) in the Karlovy Vary Region from 2011 to 2022. It primarily focuses on accidents that occurred during rides with priority rights. Data from the Fire Rescue Service, the Police of the Czech Republic, and the Emergency Medical Services of the Karlovy Vary Region were analyzed. The research aimed to identify patterns, causes of accidents, and outcomes such as injuries and property damage. The results show that insufficient attention to driving and incorrect maneuvers are common causes of accidents across all components of the Integrated Rescue System, with the highest risk observed in urban areas during afternoon and evening hours at a significance level of p=0.05. These findings emphasize the need for targeted safety training and preventive measures to reduce accident rates among rescue workers.
INTERNALIZATION OF RELIGIOUS MODERATION EDUCATION THROUGH CULTURE LITERACY WITH A NATIONAL INSIGHT
Authors: BR Rosyadi , Mundiri Akmal , Nuril Laila
Published: January 2025

The purpose of this study was to describe the strategies carried out by educators at MAN 1 Probolinggo as superior madrasas in an effort to instill religious moderation values. As well as the implementation of moderation values that were implemented through a literacy culture with a national perspective by educators at MAN 1 Probolinggo towards students. This research used a qualitative approach through case studies. The research was developed through several forms consisting of; integration, indoctrination, democratization and enculturation. The process of data analysis researchers collect data, analyze data. The results of the study showed the success of applying moderation in everyday life through a culture of literacy with a national perspective. So that the benchmark for moderation education was literacy that builds students' critical power, then teacher creativity in class management so that it accommodated the student's critical power and so that teachers indoctrinated religious moderation values in creative and interesting ways according to learners character. The results obtained from this indoctrination were students are able to be tolerant, flexible, not rigid, and open minded.
ANALYSIS OF SUITABILITY INDICATORS AND BASIC COMPETENCIES OF ISLAMIC EDUCATION LEARNING BASED ON THE REVISION OF BLOOM'S TAXONOMY
Authors: Wisono Dody , Khozin Khozin , Temarwut Taufik
Published: January 2025

The purpose of this study was to describe the suitability of indicators for basic competence in the implementation of learning plans for islamic education subjects at SMK Muhammadiyah Tanjung Redeb based on the revised bloom taxonomy. This research was a qualitative descriptive study. The research location was carried out at the Tanjung Redeb Muhammadiyah Vocational School, Berau Regency, East Kalimantan. The objects in this study were indicators and basic competencies in class XI lesson plans for islamic education which were developed by educators at the Tanjung Redeb Muhammadiyah Vocational School, Berau, East Kalimantan. Data collection techniques used documentation analysis techniques, while for data analysis techniques researchers used interactive techniques Miles, Huberman and Saldana by going through the stages of condensing data, presenting data, and drawing conclusions. As for testing the validity of the data using triangulation. The results of the study showed that there was a discrepancy at the level of basic competence with indicators of achieving competence where these indicators are below basic competence.
THE EFFECT OF USING PROJECT BASED LEARNING MODEL WITH AUTOPLAY MEDIA STUDIO ON LEARNING ACHIEVEMENT
Authors: Harahap Hasda Nami , Ritonga Asnil Aidah
Published: January 2025

The purpose of this research was to test the use of the Project-Based Learning (PjBL) model with AutoPlay Media Studio 8. Using a quantitative quasi-experimental design with a nonequivalent control group design. The sampling technique used was nonprobability sampling with purposive sampling. Data were collected by administering pre-test, post-test, and questionnaires. The average pre-test scores of both groups were relatively similar, with the experimental group scoring 50,53 and control group scoring 52,00. The average post-test score of the experimental group was 93,47, higher than the control group’s score of 84,21. The hypothesis testing resulted in a tvalue of 4,340 and a ttable value of 2,028, with a significance level (α) of 0,05. Since the calculated tvalue was greater than the ttabel value was less than o,o5, the full hypothesis (H0) was rejected and the alternative hypothesis (Ha) was accepted. The findings of this research indicated that the use of the PjBL model with AutoPlay Media Studio 8 was effective in teaching Islamic Education. Furthemore, the N-Gain test showed that the experimental group achieved a high criterion score of 87,4269, while the control group achieved a moderate criterion score of 66,5780. This suggested that students have improved their understanding of the taught material. The use of the PjBL model with the development of AutoPlay Media Studio 8 as a learning tool will create an interactive and impactful learning experience for Islamic Education at SMP IT Al-Hijrah.
ENHANCING STUDENTS’ ENGAGEMENT AND LEARNING OUTCOMES IN ISLAMIC EDUCATION BY LEVERAGING THE EFFECTIVENESS OF WORDWALL
Authors: Rahmah Rahmah , Nurhadi Muhammad , Sholikhudin M. Anang
Published: January 2025

This study explored the effectiveness of Wordwall, a digital learning tool, in improving student learning outcomes in Islamic education at Junior High School N 1 Purwosari. Using a quasi-experimental design with both experimental and control groups, the research evaluates the impact of Wordwall on student performance through pre-test and post-test assessments. Statistical analyses, including descriptive statistics, normality tests, and Islamic educationred sample T-tests. Specifically, the experimental group showed a significant increase in average scored from 70.33 (pre-test) to 84.25 (post-test), while the control group's scores increased from 65.25 to 73.58. These findings underscore Wordwall's efficacy in creating interactive and engaging learning environments, thereby enhancing student comprehension and achievement in Islamic education. The study emphasized the integration of educational technologies like Wordwall to optimize learning experiences and highlights implications for educational practice and teacher training. It advocated for educators to receive training on effectively incorporating such digital tools into their teaching methodologies, ensuring they leverage the full potential of these resources. Furthermore, the research stressed that the effectiveness of educational technologies was influenced by factors such as learning design, content quality, and teaching approaches. By adopting a more interactive pedagogical style, educators can significantly enhance student outcomes. This research contributed valuable insights into the role of digital tools in contemporary education and encourages further investigation into their integration across various subjects, ultimately fostering student engagement and success in the learning process.
THE EXISTENCE ISLAMIC EDUCATION LEARNING FORMING STUDENTS’ LEVEL OF RELIGIOUS MATURITY
Authors: Salamuddin Ahmad , Rahmat Munawar , Fahrudin Fahrudin
Published: January 2025

This research focused on analyzing the level of religious maturity of students at the junior high school level. The purpose of this study was to measure the level of student religiosity. To measure this, research was conducted using quantitative methods with 103 Muslim students as respondents using Probablity Sampling technique with stratified random sampling approach. The analysis test used was descriptive analysis, frequency distribution and normality test. The questionnaire used as many as 49 questions relating to the tendency towards religious maturity religiosity. This study found that the level of religious maturity of junior high school students is low by having a mean value of 175.59, median value 176, minimum value 135, maximum value 211, with a total value of 18,086. The implication of this study was to illustrate that islamic education learning can shape the religious maturity of students in junior high school, and the influence of religious activities carried out at school in shaping behavior that shows religious maturity.
DEVELOPING POCKET BOOK OF ISLAMIC RELIGION (POKEMON) LEARNING MEDIA TO ENHANCE THE STUDENTS’ LEARNING MOTIVATION
Authors: Sofiyatun Siti , Fauziah Zumrotul , Choiri Moh Miftahul
Published: January 2025

This research aimed to develop learning media in the form of a Pocketbook of Islamic Religion (POKEMON) using the Flipbook application. This research focused on the feasibility and the implementation of the learning media. The method of this research was Research and Development (R & D) using the ADDIE (Analysis, Design, Development, Implementation, and Evaluation) model. This model had 5 stages: First was analysis, the stage of analyzing the situation and condition in which the media is needed for the learning process. The second stage was design, which is the stage of designing the learning media being developed. The third stage was developing learning media using the flipbook application. After the media has been developed, the next stage is implementation, namely the implementation stage for students to find out the feasibility and practicality of the media. The last stage was the evaluation, which aimed to improve the product after it has been tested and implemented. The result of the study showed that the media has high feasibility with a percentage of media expert assessments of 86.7%, material experts 91.5%, and 94.2%. Furthermore, the students perceived that the POKEMON media helps and motivates them in the learning process. The media had a positive impact on students such as making it easy to understand the material, so that students become enthusiastic in learning and reading, and trains students to think critically. Thus, this media had very valid and practical to use as a media in the learning process.