bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of standardized, structured clinical case examination and traditional long-case examination for assessment of final-year medical students: a non-randomized control trial
Authors: Qureshi Fozia Umber , Sohail Shaherzad , Dar Lubna Riaz
Published: June 2022

Background and Objective: To improve the reliability and validity of assessment methods, it is always required to revisit older modalities and introduce new ways to promote students’ engagement and learning. The objective of this study was to compare standardized, structured clinical case and traditional long-case examination systems for the evaluation of clinical competency of final-year medical students.
Methods: A non-randomized control study was conducted at the Department of Obstetrics (Obs) and Gynecology (Gyne), Shalamar Medical and Dental College, Lahore, Pakistan, from January 2021 to 2022. All the final-year MBBS students were assessed by standardized, structured clinical case examination at the end of the clinical rotation of Gyne/Obs. Their scores were compared with the scores of previous year students who were examined by traditional long case at the end of the clinical rotation in the same discipline. The perceptions of
students and examiners were also obtained by using the predesigned questionnaire using the Likert scale.
Results: The mean scores obtained by the students assessed by traditional long case structured long case were 64.3 and 69.2, respectively (p = 0.001). An overall positive perception for structured long-case examination by students and examiners were seen in comparison to the traditional long-case method of assessment.
Conclusion: The standardized, structured clinical case evaluation system is better than the traditional long-case examination as it helps in identifying areas of weakness and covers a wide range of clinical skills to be assessed. However, time management for each station remains a challenge for both examiners and students.
Fractional order robust adaptive control design for actuator failure compensation in dual ball-beam system
Authors: BENCHAITA Hamza , LADACI Samir
Published: June 2022

This paper is to proposes a fractional order adaptive control scheme design for actuator failure compensation in order to balance of a ball-beam system with redundant actuators. The proposed controller is based on a fractional order sliding surface from which an adaptive actuator failure compensation control scheme is obtained. In order to control the dual ball-beam system with redundant motors, a linearized model is derived, which is subjected to actuator failures. A set of numerical simulation tests representing few selected types of actuator failures scenarios are carried out to assess the output tracking performance of the proposed controller design when dealing with such failures
Synthesis, X-ray crystal structure, DFT, Hirshfeld surfaces, energy frameworks, and molecular docking analysis of a bicyclic ortho-aminocarbonitrile derivative
Authors: Sharma Ruchika , Sankpal Sandeep Ashok , Patil Pradeep Jangonda , Murugavel Saminathan , Sundramoorthy Sonachalam , Kant Rajni
Published: June 2022

2-Amino-4-(2, 5-dimethoxyphenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile has been synthesized and characterized by conventional spectroscopic techniques (FT-IR and 1H NMR) and the three-dimensional structure elucidated by single crystal X-ray diffraction studies (SC-XRD). It exists in monoclinic crystal system with space group P21/c and lattice parameters: a = 14.641(13) Å, b = 8.653(4) Å, c = 16.609(10) Å, β = 116.34(3)°, and Z = 4. In the crystal packing, molecules are connected through N-H···O and N-H···N intermolecular and intramolecular C-H···O interactions. The N1-H11···N2 interaction results in the formation of a dimer corresponding to R22(12) graph-set motif. The molecular structure has been theoretically optimized by using density functional theory (DFT) with the basis set B3LYP/6-311G (d,p). The optimized bond geometry shows consistency with the SC-XRD data. Besides this, the molecular electrostatic potential (MEP), Mulliken charges, and frontier molecular orbital analysis have been described. The dnorm, shape index, curvedness, crystal voids, 2D fingerprint (FP) plots, and 3D energy frameworks using Hirshfeld surface (HS) studies have also been computed and investigated. The molecular docking studies for 2-amino-4-(2, 5-dimethoxyphenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile with DNA gyrase/lanosterol 14α-demethylase suggest that the compound may act as an active antimicrobial drug.
Synthesis, molecular docking, and biological evaluation of methyl-5-(hydroxyimino)-3-(aryl-substituted)hexanoate derivatives
Authors: Gudimani Parashuram , Shastri Samundeeswari Lokesh , Pawar Varsha , Hebbar Nagashree Uday , Shastri Lokesh Anand , Joshi Shrinivas , Vootla Shyam Kumar , Khanapure Sheela , Sunagar Vinay
Published: June 2022

Beta-aryl keto hexanoic acids (5a-l) were synthesized efficiently, followed by esterification that afforded beta-aryl keto methylhexanoates (6a-l). The chemo-selective ketoxime beta-aryl methyl hexanoates (7a-l) were isolated in good yields. Spectroscopic methods were used to characterize the obtained moieties. The antioxidant, anti-inflammatory, and antibacterial properties of the effectively synthesized compounds 7a-l were also investigated. The anti-inflammatory activity of the compounds 7c, 7f, 7i, and 7l was excellent, with a low IC50 value at micromolar concentration, which was much better than the reference diclofenac. All synthesized compounds 7a-l were assessed for their in vitro antibacterial activity against S. aureus, B. subtilis and E. coli.  Most of the compounds exhibited promising activity against Gram-positive bacterial strain, compound 7i showed excellent activity compared to standard streptomycin and in the case of E. coli, compounds 7b, 7c, 7j, 7k and 7l have shown moderate activity. Further, the cytotoxic activities of the compounds were assessed against lung cancer cells (A549) by using MTT assay. The possible interaction mechanism of the molecules 7c and 7g with Gram-negative strain E. coli DNA gyrase B in complex with PDB ID: 4DUH was studied.
Effect of calcination temperature on the structure and morphology of zinc oxide nanoparticles synthesized by base-catalyzed aqueous sol-gel process
Authors: Zahra Samreen , Qaisa Saboora , Sheikh Asma , Bukhari Hamim , Amin Chaudhry Athar
Published: June 2022

This study reports the base-catalyzed aqueous sol-gel synthesis of zinc oxide nanoparticles. The solution was primarily comprised of zinc nitrate hexahydrate as a metal precursor, isopropyl alcohol and water as solvents, and glycerin as a stabilizing agent. The effect of calcination temperature on the structure and morphology of the prepared nanoparticles was investigated by varying the calcination temperature from 500 to 900 °C. The X-ray diffraction analysis, infrared spectroscopy, thermogravimetric analysis, and field emission scanning electron microscopy were employed to determine the crystal structure, surface functional groups, thermal stability, and surface morphology of the nanoparticles. The particle size was found to be directly proportional to the calcination temperature.
Ultra-performance liquid chromatography determination of related compounds of molindone in drug substances
Authors: Nagarajan Balaji , Manoharan Gunasekar , Shanmugam Ganapathy Narayanan , Palaniyappan Nataraj , Yarragunta Abhinav
Published: June 2022

Effective chromatographic separation was achieved on a phenyl-hexyl stationary phase (50×2.1 mm, 1.9 micron particles) with the economical and straightforward mobile phase combination delivered in isocratic mode at a flow rate of 0.6 mL/min at 254 nm using a ultra-performance liquid chromatography (UPLC) system. In the developed method, the resolution between molindone and its related compounds was more significant than 2.0. Regression analysis shows an r2 value (correlation coefficient) greater than 0.999 for molindone and its associated compounds. This method could detect related compounds of molindone at a level below 0.009% with respect to a test concentration of 500 µg/mL for a 2.0 µL injection volume. The method has shown good, consistent recoveries for related compounds (90-110%). The test solution was found to be stable in the diluent for 48 hours. The drug was subjected to stress conditions. The mass balance was found to be close to 99.3%.
Molecular dynamics of fibric acids
Authors: Miller Chad , Schildcrout Steven , Mettee Howard , Balendiran Ganesaratnam
Published: June 2022

1H- and 13C-NMR chemical shifts were measured for four fibric acids (bezafibrate, clofibric acid, fenofibric acid, and gemfibrozil), which are lipid-lowering drugs. Correlation is found with DFT-computed chemical shifts from the conformational analysis. Equilibrium populations of optimized conformers at 298 K are very different when based on computed Gibbs energies rather than on potential energies. This is due to the significant entropic advantages of extended rather than bent conformational shapes. Abundant conformers with intramolecular hydrogen bonding via five-member rings are computed for three fibric acids, but not gemfibrozil, which lacks suitable connectivity of carboxyl and phenoxy groups. Trends in computed atom-positional deviations, molecular volumes, surface areas, and dipole moments among the fibric acids and their constituent conformations indicate that bezafibrate has the greatest hydrophilicity and fenofibric acid has the greatest flexibility. Theoretical and experimental comparison of chemical shifts of standards with sufficient overlap of fragments containing common atoms, groups, and connectivity may provide a reliable minimal set to benchmark and generate leads.
Synthesis, characterization and Hirshfeld surface analysis of 2-aminobenzothiazol with 4-fluorobenzoic acid co-crystal
Authors: Banerjee Bubun , Sharma Varun , Sharma Aditi , Kaur Gurpreet , Gupta Vivek Kumar
Published: June 2022

The co-crystal of 2-aminobenzothiazol with 4-fluorobenzoic acid were synthesized and characterized by elemental analyses, spectral studies (FT-IR, NMR, HRMS) and single-crystal X-ray diffraction analysis. This compound co-crystallizes in the monoclinic space group P21/c (no. 14), a = 11.7869(14) Å, b = 4.0326(5) Å, c = 27.625(3) Å, β = 92.731(10)°, V = 1311.6(3) Å3, Z = 4, T = 293(2) K, μ(CuKα) = 2.345 mm-1, Dcalc = 1.470 g/cm3, 3568 reflections measured (7.508° ≤ 2Θ ≤ 134.202°), 2280 unique (Rint = 0.0262, Rsigma = 0.0413) which were used in all calculations. The final R1 was 0.0446 (I > 2σ(I)) and wR2 was 0.1274 (all data). The crystal structure is stabilized by elaborate system of N–H···O and O-H···O hydrogen bonds to form supramolecular structures. Furthermore, the 3D Hirshfeld surfaces and the associated 2D fingerprint plots have been analyzed for molecular interactions.
A theoretical density functional theory calculation-based analysis of conformers of p-xylene
Authors: Suhail Mohammad
Published: June 2022

Different conformers of many aliphatic compounds such as ethane, butane, cyclohexane and their derivatives have been studied to find the most reactive as well as the most stable conformer. For the first time, two conformers of p-xylene were found using theoretical DFT calculation and the vibrational modes, Raman activity, and other spectra of each conformer were also studied. The most significant data that clearly distinguished both conformers was depolarization spectra. Besides, many other parameters were found different in both conformers of p-xylene such as Mulliken charge’s, optimization energy, HOMO’s of both conformers. Also, the presented study predicts, why eclipsed conformer of p-xylene is more reactive than staggered conformer. The reactivity of the eclipsed form is explained on the basis of HOMO-LUMO energy gap. Also, the presented study opens the door for future work to be done because each conformer can produce a specific product. Moreover, the rates of reaction are also dependent on the conformers and their relative stability.
Phenazine and 10H-phenothiazine cocrystal stabilized by N-H···N and C-H···S hydrogen bonds
Authors: Mehmood Tahir , Patel Bhumiben Chandubhai , Reddy Jayarama Prakasha
Published: June 2022

A 1:1 co-crystal of phenazine and phenothiazine was prepared. The crystal structure was determined by using a single crystal X-ray crystallography technique. Analysis of the crystal revealed that the molecular complex crystallizes in monoclinic P21/n space group, C12H8N2·C12H9NS, a = 9.068(2) Å, b = 8.872(2) Å, c = 23.935(4) Å, β = 92.16(4)°, V = 1924.1(6) Å3, Z = 4, T = 293(2) K, μ(MoKα) = 0.182 mm-1, Dcalc = 1.310 g/cm3, 8057 reflections measured (3.4° ≤ 2Θ ≤ 46.54°), 2751 unique (Rint = 0.0559, Rsigma = 0.0618) which were used in all calculations. The final R1 was 0.0548 (>2sigma(I)) and wR2 was 0.1029 (all data). The molecules recognize each other through N-H···N and C-H···N hydrogen bonds, thus producing a tetramer unit. These units further interact with one another via C-H···S hydrogen bonds.
Synthesis, crystal structure, and antidiabetic property of hydrazine functionalized Schiff base: 1,2-Di(benzylidene)hydrazine
Authors: Diyali Nilankar , Chettri Meena , De Abhranil , Biswas Bhaskar
Published: June 2022

Hydrazine functionalized Schiff base, 1,2-di(benzylidene)hydrazine has been synthesized through a condensation between hydrazine and benzaldehyde under reflux, and structurally characterized. The crystal structure analysis reveals that the Schiff base crystallizes in an orthorhombic crystal system with the Pbcn space group. Crystal data for C14H12N2: a = 13.130(2) Å, b = 11.801(2) Å, c = 7.5649(16) Å, V = 1172.1(4) Å3, Z = 4, T = 298.0(2) K, μ(MoKα) = 0.071 mm-1, Dcalc = 1.180 g/cm3, 10252 reflections measured (6.206° ≤ 2Θ ≤ 65.352°), 2027 unique (Rint = 0.0381, Rsigma = 0.0283) which were used in all calculations. The final R1 was 0.0627 (I > 2σ(I)) and wR2 was 0.2462 (all data). It is evident that the imine protons are intramolecularly locked with the imine-N bond, and the phenyl rings exist in anti orientation with respect to the =N-N= bond adopting a nearly planar conformation. The Schiff base grows a one-dimensional framework in the crystalline phase through long-distant C-H···π interaction. Hirshfeld surface and energy framework analyses have also been performed to understand the supramolecular forces and their contributions meticulously. The hydrazine functionalized Schiff base showed an excellent antidiabetic activity through α-amylase inhibitory assay relative to a standard compound, acarbose under an identical condition.
Graphical Contents
Authors: Arslan Hakan
Published: June 2022

Graphical Contents
Anti-fungal activity of anthraquinone derivatives (Part 1)
Authors:   A.B.Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan, Kharlamova T.V.
Published: June 2022

The problems of treatment and prevention of infectious diseases, due to the diversity of biological forms of pathogens, the constant emergence of multi-resistant forms, the emergence of new types of dangerous pathogens, determine the relevance of the problem of creating new antimicrobial agents. Over the past few decades, there has been an increase in the incidence of fungal infections worldwide, as well as an increase in the resistance of some types of fungi to various antifungal drugs used in medical practice. The purpose of the review is to provide information on the current state of fungal diseases and the search for new antifungal structures among natural compounds, in particular anthraquinone derivatives. Objects. Derivatives of 9,10-anthraquinone: chrysophanol, emodin, physсion, rhein, aloe-emodin). Results. Currently, special attention has been paid to natural sources of antimicrobial agents, which can be considered as an alternative to traditionally used drugs. Nature is a valuable source of new compounds and a rich arsenal of biologically active metabolites for the search for new drugs. Chemistry of anthraquinone derivatives is an independent and extensive field of organic and bioorganic chemistry with a wide range of practical applications. Quite a large number of compounds of the anthraquinone series have been found in plants, animals, and microorganisms. Many natural and synthetic derivatives of anthraquinones exhibit a variety of pharmacological activities, among which compounds with antitumor, cytostatic, anti-inflammatory, hormonal, antiviral, and other activities have been identified. The review analyzes the antifungal effects of various types of natural anthraquinone molecules (chrysophanol, emodin, physсion, rhein, aloe-emodin), as well as some structurally related derivatives, to assess the effect of structural parameters of molecules on their activity. Conclusion. Natural objects contain a variety of biologically active derivatives of 9,10-anthraquinone. They can be considered as promising structures for the search for new antifungal agents.
Synthesis and antimicrobial activity of fluorobenzoic acid amides
Authors:   A.B.Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan, Issayeva U.B. , Akhmetova G.S. ,   A.B.Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan, Praliyev K.D. ,   A.B.Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan, Datkhayev U.M. ,   Kazakh National Medical University named after S.D.AsfendiyarovNAO, Almaty, Kazakhstan, Omyrzakov М.Т. ,   Kazakh National Medical University named after S.D.AsfendiyarovNAO, Almaty, Kazakhstan, Seidahmetova R.B. ,   PhytochemistryJSC NIH, Karaganda, Kazakhstan, Abdambayev D.A. ,   Kazakh National Medical University named after S.D.AsfendiyarovNAO, Almaty, Kazakhstan, Seilkhanov T.M. ,   Kokshetau State University named after sh. Ualikhanov, Kazakhstan
Published: June 2022

The chemistry of organofluorine compounds, before the eyes of one generation, has turned from a small branch of organic chemistry into a large independent branch of exceptionally important theoretical and practical significance. Numerous studies have confirmed the high biological activity of a number of fluorine-containing organic compounds, as a result of which such drugs as fluoroquinolone antibiotics, risperidone, fluorophenazine, haloperidol, etc. have been created and are successfully used. Among amide derivatives, substances with antibacterial, anticonvulsant, analgesic and antifungal properties have been found. The purpose of this work is to develop ways to obtain a number of new potentially biologically active fluorine-containing amides based on morpholine, and to study their biological activity. Results and discussion: on the basis of cyclic amine - morpholine, by acylation with para-, meta-, ortho-fluorobenzoyl chlorides, reaction according to Schotten-Bauman, the corresponding amides of para-, meta-, ortho-fluorobenzoic acids were synthesized. The reaction was carried out in absolute benzene with cooling and the ratio of amine: acylating agent = 2:1. Inclusion complexes of compounds with b-cyclodextrin have been obtained. The composition and structure of the synthesized compounds were confirmed by data of elemental analysis and IR, NMR spectroscopy, individuality - by thin-layer chromatography. The synthesized compounds under the codes ПМП-4 - ПМП-6 were studied in an in vitro experiment for antimicrobial activity. All compounds exhibit pronounced antibacterial activity against the presented gram-positive and gram-negative test strains, in particular, they exhibit moderate activity against the gram-positive strain of Staphylococcus aureus ATCC 6538. The compound ПМП-6 exhibits moderate activity against gram-positive bacteria Bacillus subtilis and moderate antibacterial action against the gram-negative test strain Escherichia coli ATCC 25922. The compound ПМП-6 also has antifungal activity against the yeast fungus Candida albicans ATCC 10231.
Synthesis and characterization of copper (II) chloride complexes with non-ionic polymers PEG and PVP
Authors:   Al-Farabi Kazakh National University, Almaty, Kazakhstan, Bakirova B.S. , Smagulova I.A. ,   Al-Farabi Kazakh National University, Almaty, Kazakhstan, Akbayeva D.N. ,   Al-Farabi Kazakh National University, Almaty, Kazakhstan
Published: June 2022

The compositions of polymer-metal complexes based on copper (II) chloride and polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) have been determined by the potentiometric method. Based on the experimental data, obtained to determine the composition of the complex, the titration curves have been plotted, and the optimal molar ratios of the reacting components have been found. The Bjerrum’s formation functions have been calculated. The obtained data indicate the formation of the polymer copper complexes, in which there are two PEG mono-links per two copper ions-complexing agent (1:2 in the Cu2+-PEG), and in the case of PVP, there are three ones (1:3 in the Cu2+-PVP). On the basis of thermodynamic constants of stability, using isotherm equations and isobars of Vant Hoff and Gibbs, Gibbs’ energy (DrG0), enthalpy (DrH0) and entropy (DrS0) changes have been calculated. The complexation process in the Cu2+-PEG and Cu2+-PEG systems is characterized by negative Gibbs’ energies, which indicates a spontaneous occurrence of the polymer-metal complex (PMC) formation process in these systems. In contrast, the complexation of copper ions with PEG is accompanied by the large positive enthalpy values, which indicate that the interaction of Cu2+ with the functional groups of the polymer is energetically unfavorable. The entropy values ​​are positive, which can be explained by the dehydration of ions and functional groups, acting as ligands and a chelating effect during complexation, when one ion binds to several functional groups. The structure of the synthesized complexes has been investigated by IR spectroscopy.
Some peculiarities of obtaining composite materials, based on alicyclic (co)polyimide and polyethylene glycol (Review)
Authors:   A.B. Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan, Umirzakova M.B. , Iskakov R.M. ,   K.I. Satpayev Kazakh National Technical University, Sariyeva R.B. ,   A.B. Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan, Yespenbetov A.A. ,   A.B. Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan, Kaynarbayeva Zh.N. ,   A.B. Bekturov Institute of Chemical Sciences JSC, Almaty, Kazakhstan
Published: June 2022

The current trend in obtaining new structural polymeric materials for mechanical engineering, agriculture, food industry, instrumentation, electrical engineering, electronics, and other industries is the development and use of mixed compositions based on structural thermoplastics. A special place among the initial components for the creation of structural materials is occupied by heat-resistant polymers, in particular polyimides. Сurrently, lots of thermoplastic and thermosetting polyimides and other imide-containing film-forming polymers have been synthesized and successfully processed into composite materials with special properties.The goal of this research was to consider the features of obtaining binary and ternary polymer mixtures based on alicyclic (co)polyimides containing polyethylene glycol with other polymeric additives and the mineral montmorillonite. Based on the IR spectroscopy data of compositions and films, the effect of the surfactant polyethylene glycol on the compatibility of components in the composition and the possible mechanism of interactions of polyfunctional polymers as well as alkylated montmorillonite is shown. The formation peculiarities of ternary compositions (co)polyimide + polyethylene glycol + an additional component (polyacrylamide, polyethyleneterephthalate, alkylated montmorillonite) is provided. The thermal and physical-mechanical properties of the films formed from composites, determined by the appropriate methods of thermogravimetric analysis and stretching of the material at a constant strain rate are presented. It was established that the best indicators of the studied properties are polyimide (copolyimide) + polyethylene glycol + alkylated montmorillonite composite films where the decomposition start temperature is 430 ºС, the breaking strength is 200 MPa, and the relative extension is about 24%.
РИНОК ПРАЦІ УКРАЇНИ: ТЕНДЕНЦІЇ ФУНКЦІОНУВАННЯ В УМОВАХ ВОЄННОГО СТАНУ
Authors: Комліченко Оксана , Ротань Наталя
Published: June 2022

В дослідженні уточнено поняття «ринок праці». Визначений вплив воєнного стану на ринок праці країни. Виявлені зміни в попиті і пропозиції робочої сили, ступені задоволення інтересів зацікавлених сторін, рівні зайнятості та безробіття. Визначені професії, які користуються найбільшим попитом.
БАНКІВСЬКІ ДОХОДИ В УМОВАХ ФОРМУВАННЯ ЦИФРОВОЇ ЕКОНОМІКИ УКРАЇНИ
Authors: Реверчук С. , Творидло О.
Published: June 2022

Цифрова трансформація в банківському секторі є безперервним процесом, який впливає як на зовнішнє, так і на його внутрішнє середовище шляхом перебудови чинних процесів та існуючих методів. Існує низка причин здійснення цифрової трансформації у банківському секторі, наприклад, обслуговування віддалених районів без фізичних філій, диференціація серед конкурентів або зниження операційних витрат. У цій статті досліджується рівень впливу цифровізації економіки на доходи банківського сектору України. У статті визначено поняття банківський дохід і проаналізовано динаміку та структуру доходів вітчизняних банків. Досліджено практичний внесок керівників банків у прогнозування доходів та стан загальної доходності установи в умовах переходу до нової цифрової ери. Дане дослідження дасть можливість глибше зрозуміти керівниками банківських установ контури майбутньої цифровізації банківського сектору та виявити нові можливості забезпечення доходності банків в оновлених економічних умовах.
ПОРІВНЯЛЬНІ ХАРАКТЕРИСТИКИ ГЕНЕРУЮЧИХ ПОТУЖНОСТЕЙ ТА ЇХ ОДНОЧАСНИЙ ВПЛИВ НА РОБОТУ ЕНЕРГОСИСТЕМИ УКРАЇНИ
Authors: Філатов Володимир , Топал Олександр , Голенко Ірина
Published: June 2022

Визначено важливі характеристики/показники, що впливають на ефективність роботи електрогенеруючих потужностей. Виконано порівняльний аналіз типів електрогенеруючих потужностей за цими показниками. Зроблено висновки щодо можливості зміни структури та впровадження нових маневрових генеруючих потужностей виходячи з необхідності ефективного регулювання частоти в енергосистемі.
ВИКОРИСТАННЯ МЕТОДІВ МАШИННОГО НАВЧАННЯ ДЛЯ КЛАСИФІКАЦІЇ СЕРЦЕВИХ ЗАХВОРЮВАНЬ ЗА ДАНИМИ ЕКГ ТА ЗАСТОСУВАННЯ СУЧАCНИХ ГЕНЕРАТИВНО ЗМАГАЛЬНИХ МЕРЕЖ ДЛЯ ЗБІЛЬШЕННЯ НАВЧАЛЬНОЇ ВИБІРКИ
Authors: Данилов Валерій , Зарицький Олексій
Published: June 2022

Актуальність роботи полягає у тому, що дослідження в області серцево-судинних захворювань можуть суттєво зменшити смертність у розвинутих країнах. Мета роботи– дослідження системи класифікації серцевих захворювань за даними ЕКГ. Було застосовано WGAN для генерації додаткових елементів навчальної вибірки і згорткову нейронну мережу для класифікації. В дослідженні розглянуто класифікацію з використанням фрактальної розмірності даних. За допомогою застосування WGAN вдалося значно підвищити якість навчальної вибірки і як результат точність класифікації.
FEATURES OF BIM TECHNOLOGIES IN GEODETIC WORKS
Authors: Arsenieva Nataliia
Published: June 2022

BIM is a digital 3D modeling system that includes a range of data where you can plan, design, build and manage a project digitally. BIM is smart and knows how a particular facility works, this will reduce the risk of any problems during the construction phase. The idea is that you use the system to create your own design and you can add all the listed objects. You should be able to click on the object and find out all the necessary information about the specifications, ie the manufacturer's standards. This is very useful, for example, at the construction planning stage. BIM is aimed at an architect, designer or designer. Modern construction has almost completely switched to automatic design systems. This method of building 3D models has reduced the time of project preparation and increased its accuracy and quality. Geodetic surveys for construction are most often performed using Building Information Modeling (BIM) technology. Using it at all stages of construction of a building or linear structure, you can reproduce the smallest nuances of its structure, indicating all the financial, technological and technical parameters.
Micropropagation of Mokara Orchid by Temporary Immersion System Technique
Authors: Minh Tran Van
Published: June 2022

Based young leaves of Mokara Leuen Berger Gold were used as cultured materials. Callus was initiated and increase biomass on medium of semisolid and liquid cultures: MS medium supplemented with CW (30%), sucrose (30 g/l), 2.4D (1 mg/l). Callus was used as materials for initiation and biomass propagation on medium: (1) MS medium supplemented with NAA (1 mg/l), B1 (5 mg/l), Adenin sulfate (10 mg/l), peptone (1 g/l), CW (10%), sucrose (30 g/l) (2) MS medium supplemented with 2.4D (1 mg/l), CW (30%), Adenin sulfate (10 mg/l), peptone (1 g/l), CW (10%), sucrose (30 g/l). Semisolid medium for callus cell regeneration and to induce multiple shoots were: MS medium supplemented with BA (0.5 mg/l), B1 (5 mg/l), Adenin sulfate (10 mg/l), peptone (1 g/l), CW (10%), sucrose (20 g/l). Multiple-shoots were propagated on MS medium supplemented with BA (0.5 mg/l), B1 (5 mg/l), CW (10%), sucrose (20 g/l). Propagation of multiple-shoots in TIS on MS medium supplemented with BA (0.5 mg/l), B1 (5 mg/l), CW (10%), sucrose (20 g/l). Interval culture time was optimum for 2 hours floating and 1 minute rising. Plantlets were induced roots on MS medium supplemented with NAA (1 mg/l), B1 (5 mg/l), CW (10%), sucrose (20 g/l). Experiments on callus formation and callus growth of mokara orchids both on semi-solid medium (agar) and liquid medium to create callus suspension, the best medium selected was: MS supplemented with 2.4D (1 mg/l), CW (30%), sucrose (30 g/l)
Internalization of Learning Motivation in Literary Text-Based Qiraah Learning
Authors: Muhammad Ridha  , Muassomah
Published: June 2022

Learning motivation has become a serious problem in various educational institutions because it has implications for students’ interest and focuses on learning, the higher the motivation to learn, the higher the interest and focus of student learning. This research aims to instill students’ learning motivation through learning maharah qiraah (reading skills) using the teaching material of the story of Al-Hub Al-Maktum written by Prof. Drs. Muhaiban. This research uses a descriptive qualitative method to examine the data through data analysis of observations, interviews, and document studies with research samples from MA Al-Irsyad Tengaran 7 students in Batu City. The data field shows that students are less motivated by the learning materials that have been applied, which was implicated in the decreased interest and focus of students learning during teaching and learning activities. The results of the research show that there is an increase in students learning motivation in teaching and learning activities maharah qiraah using the teaching material of the story of Al-Hub Al-Maktum. These can be seen from the enthusiasm of students for participating in learning and the value calculations of before and after learning are increased by 9.96. The learning motivation that increases in students has able to influence student’s interest and focus on learning during teaching and learning activities.
Ht-El System In Realizing The Escalation Of Electronic Certificates With Legal Certainty (Study Of The Land Office Of Karanganyar Regency)
Authors: Aziz Zaelani Muhammad , Rudatyo Rudatyo
Published: June 2022

This research addresses the following topics: (i) the implementation of the HT-el system at the Karanganyar Regency Land Office; and (ii) legal issues encountered while implementing the HT-el system at the Karanganyar Regency Land Office. This empirical study expands on describing the policy approach as well as micro-interactional effects. The research's findings are: First, the Karanganyar Regency Land Office implemented the HT-el system in accordance with Minister of ATR/BPN Regulation Number 5 of 2020, with empirical evidence of data recapitulation of the number of HT-el applications for the 2020 and 2021 periods, accompanied by risk management analysis. Second, the legal issues of implementing the HT-el system at the Karanganyar Regency Land Office include the substantive issue of a lack of implementing regulations as implementing guidelines and implementation parameters, the issue of structural apparatus lack of human resources overcoming network error problems, budgeting for repair and maintenance as the primary means of HT-el services, and socio-cultural issues; the public's lack of enthusiasm due to a lack of socialization and assistance regarding the ease of HT-el services. Suggestions for research include the Ministry of ATR/BPN issuing implementing regulations that accommodate the standardization parameters for the implementation of the HT-el system in the region, as well as the Head and Employees of the Land Office of Karanganyar Regency increasing socialization and assistance in the use of HT-el services and systems to the community, as well as employee training in overcoming network problems.
Implementation Of The Balanced Scorecard In Improving The Performance Of Private Universities
Authors: Ruhviyanti Novi , Wasliman Iim , Hanafiah Hanafiah , Tejawiani Ida
Published: June 2022

The role of private universities in improving quality must accommodate all aspects of the performance of the tridharma of higher education. The rapid development of higher education institutions must be ready to change, changes that occur in the global business environment also trigger the increasing intensity of competition between higher education service providers, so that each higher education service provider will try to offer high performance higher education services. The purpose of this research is to see how far the implementation of BSC in improving the performance of private universities. Specifically, this study describes four perspectives, including: (1) financial perspective, (2) customer perspective, (3) internal business process perspective (4) learning and growth perspective.This study uses a descriptive method with a qualitative approach and data collection by conducting observations, interviews, and documentation studies. From the research results indicate that the implementation of the BSC has been applied in a systematic, measurable and planned manner so that the Vision, Mission and objectives are achieved. In implementation there is a balance between financial and non-financial.
Financial Distress And Debt To Asset Ratio Can Moderate Stock Price Problems
Authors: Sunaryo Deni
Published: June 2022

This study aims to analyze the effect of Return On Equity, Total Asset Turn Over, and Cash Ratio on Stock Prices moderated by Financial Distress and Debt to Asset Ratio. This study uses the objects of the Property and Real Estate sub-sector companies on the Southeast Asian Stock Exchange for the period 2012-2020. The data collected is secondary data with the documentation method in the form of the company's annual report. The analytical tool used to test the hypothesis is SPSS 26. The sampling method used in this study using purposive sampling technique obtained 11 companies that present complete financial statements, so that obtained as many as 99 samples. The analytical technique used is descriptive statistical analysis, classical assumption test,MRA, multiple linear regression, t test, and f test. The result of the research partiallyconcludes that Return On Equity has no effect on Stock Price, Total Asset Turn Over has a significant effect on Stock Price, and Cash Ratio has a significant effect on Stock Price. The results of the study simultaneously Return On Equity, Total Asset Turn Over, and Cash Ratio significant effect on stock prices. MRA research results shows that Financial Distress Moderate Return On Equity on Stock Prices, Financial Distress moderate Total Asset Turn Over to Stock Price, Financial Distress does not moderate Cash Ratio to Stock Price, Debt To Asset Ratio moderates Return On Equity to Stock Price, Debt To Asset Ratio moderate Total Asset Turn Over to Stock Price, and Debt To Asset Ratio does not moderate Cash Ratio to the Share Price.
Ugaling Pinoy: A Mobile Learning Game Application to Enhance Learning in Values Subject of Elementary Pupils
Authors: Escultor Marites , Moises Laura
Published: June 2022

The fact that elementary students are still in the pick of their childhood who loves playing, learning values could be much easier if a game-type of learning will be used. The Ugaling Pinoy: A Mobile Learning Game Application About Edukasyon sa Pagpapakatao (Values Subject), is a mobile learning game developed to teach young children good manners and right conduct in different places and situations. This study was conducted to develop a learning game in values for elementary pupils and to evaluate its effect in their learning specifically in values subject. The system used various software to make the system more interesting and attractive to the end-users such as Basic for Android for coding, Adobe Photoshop for graphics, and Adobe Flash for animation. It was validated by ten (10) IT experts and five (5) values teachers. A total of 30 pupils were selected as the respondents of the study using purposive sampling. Mean, percentage and t-test were the statistical tools employed in the study. The result revealed that the developed learning game has a positive effect on the pupils’ learning in values subject. It was concluded that the system was user friendly and is very good in its performance. Furthermore, the study identifies positive effects of learning games - an aspect of intervention plan and demonstrates the potential of such learning games in improving the good manners and right conduct of the pupils.

Keywords: learning values, mobile learning games, Filipino values, t-test
Moderating Competitive Advantage On Factors Affecting Economic Performance
Authors: Eksandy Arry , Paramitha Sofia Irma
Published: June 2022

The purpose of this study is to determine the effect of environmental performance, corporate image, corporate social performance on economic performance with competitive advantage as a moderating. The population of this study includes all manufacturing company listed on the Indonesia Stock Exchange in the 2014-2018 period. The sampling technique used purposive sampling technique. Based on predetermined criteria obtained 11 companies. The type of data used is secondary data obtained from the Indonesia Stock Exchange website. The analytical method used is panel data logistic regression analysis. The results showed that environmental performance, corporate social performance, competitive advantage proxied by economic performance had a negatif effect, corporate imageproxied by economic performance had no effect. While environmental performance, corporate social performance proxied by economic performance had a positif effect after moderating by competitive advantage, corporate imageproxied by economic performance had no effecteffect after moderating by competitive advantage.
Management of Academic Supervision to Improve Teacher Performance at MTsN 3 and MTsN 4 Banjarmasin City
Authors: Adnan Adnan , Sujiarto Heru , Iriantara Yosal , Mulianai Yenny
Published: June 2022

This study is motivated by low teacher performance at MTsN 3 and MTsN 4 Banjarmasin, such as: (a) the unpreparedness of the teachers in carrying out teaching, (b) a number of teachers do not have textbooks and do not arrange teaching units, (c) low basic skills, especially in evaluating learning processes. This study focused on 1) academic supervision policies and programs to improve teacher performance; 2) implementation of academic supervision policies and programs to improve teacher performance; 3) academic supervision problems to improve teacher performance; and 4) future solutions and improvements on the implementation of academic supervision to improve teacher performance at MTsN 3 and MTsN 4 Banjarmasin. This study used a qualitative approach with a case study method. Data were collected using interviews, observation, and document studies to then further analyzed using triangulation techniques. This study used management theory by Griffin and supervision theory by Daresh, and performance theory by Hersey & Blanchard. Based on the results; 1) academic supervision policies and programs were not optimal to improve teacher performance; 2) academic supervision policies and programs to improve teacher performance based on assessment aspects have been carried out, but administrative requirements for teacher performance appraisals have not been fulfilled; 3) implementation of academic supervision to improve teacher performance is faced with low mentality, infrastructure support, financing, and unclear division of academic supervision tasks, and 4) future solutions and improvements on implementation of academic supervision to improve teacher performance at MTsN 3 and MTsN 4 Banjarmasin is through providing clarity on planning, implementation, and evaluation of academic supervision to improve teacher performance. Thus, it can be concluded that the management of academic supervision to improve teacher performance has been carried out through management stages but is still not maximized to comply with national education standards.
The Islamic Response to Modernity and Ecological Crisis
Authors: Hidayati Tri , Kurniawan Wiwit
Published: June 2022

The problem of the ecological crisis and various environmental issues that arise today cannot be separated from the role of religion and religious communities as entities that are in contact with the environment. Muslims as the largest number of people in Indonesia have an influenced by their lifestyle in the environment. Therefore, awareness of environmental preservation is an important thing to consider in the actions and behavior of Muslims. This study aims to reveal how Islam responds to environmental issues. This research is a literature study using discourse analysis. The results of the study show that Islamic thought provides a critique of modernity that is misguided, and it causes human domination over nature. In addition, there is an Islamic understanding of new interpretations of the doctrine that can build relationships between humans and others. Also, there are daily practices of Muslims that show respect for nature.
Water Quality Index (WQI) to Evaluate Groundwater Quality in Chickmagaluru District, South Karnataka, India
Authors: G PRAMODA , Balasubrahmanian Ayyappan , Nagaraju Doddaia , Krishnamurthy Vybhav
Published: June 2022

Groundwater quality analysis is essentially prima facie in the present scenario. To evaluate groundwater quality 14 different physiochemical parameters were analyzed for groundwater samples in the study area. Water Quality Index (WQIs) is a composite indicator of water quality. The water quality index contains various parameters that can be quickly and easily communicated to its intended audience. WQI is one of the most effective techniques for determining the appropriateness of groundwater for drinking purposes. The extracted components indicate that geological, agricultural, rainfall, household wastewater, and industrial activities are causing the sources to exceed the permissible limit. The present study contributes in understanding the groundwater quality in the Chickmagaluru district. It also helps in the understanding hydrogeochemical process of groundwater and effective interpretation of groundwater.
Provenance, tectonic setting and palaeoclimate of Proterozoic Jiran Sandstone, Southeastern Rajasthan, India: A petrographic approach
Authors: Zaid Mohammad , Hasan Mujeebul , Khan Dr. Abdullah
Published: June 2022

Proterozoic Jiran Sandstone rests unconformably on Binota Shale and Khori-Malan Conglomerate. The Jiran Sandstone is comprised mainly of fine to medium-grained, varicolored, thickly bedded sandstones, showing diverse primary sedimentary structures such as ripple marks, planar, and trough cross-bedding. Petrographically, Jiran Sandstone is of mainly quartzarenite which is composed of varieties of quartz with ultra-scarcity of feldspar, lithic fragments, micas, and heavy minerals. Quartz is more abundant mineral shown by X-ray Diffraction Analysis. The provenance, tectonic setting, and paleoclimatic condition of the Jiran sandstone were evaluated using integrated petrographic studies. Analysis pursuant, monocrystalline and polycrystalline quartz grains and heavy minerals are driven primarily from metamorphic and plutonic Precambrian basement source rocks of a craton interior setting with a minor quartzose recycled sedimentary source material. Intensive chemical weathering in warm and humid paleoclimate is indicated by lack of feldspar and rock fragments.
Abundance of Sulphur in Paleogene coals of North-East India and Its Paleo-environmental Implications
Authors: Manabendra Nath Manabendra Nath
Published: June 2022

The present paper entails the occurrence and distribution of different forms of sulphur in Paleogene coals of north-eastern India. All the coal seams present in the north-eastern region of India are characterized by the presence of high sulphur with total sulphur content ranging from 3 to 7%. Among all the forms of sulphur recognised, organic sulphur is dominant. The total sulphur content originated in the Platform area for Eocene coal under stable shelf condition vary from 4.20 % to 6.01 % for Jaintia Hills, from 2.78 % to 4.01 % for Khasi Hills and from 1.90 % to 3.00 % for Garo Hills, whereas Oligocene coal evolved under the foredeep basin have total sulphur ranging in from 2.90 % and 6.60 %. In the Eocene coals, there is a distinct lateral and vertical variation of sulphur i.e., sulphur content increases from the bottom to the top seam and also from western side of Meghalaya to the eastern side. This lateral variation of sulphur was because of the more marine nature of the Eastern Meghalaya than the Western Meghalaya. Both Eocene and Oligocene coals have been derived from seawater as evidenced by the presence of pyritic form of sulphur. Study of forms of sulphur also suggests that the deposition of the coals in a different part of the region was influenced by roof strata, peat-forming plant communities, tectonic uplifting, and marine or freshwater incursion.
The Peer-Review Problem: a sedimentological perspective
Authors: Shanmugham G
Published: June 2022

Albert Einstein, one of the greatest physicists of all time, had a deep disdain for peer review. The peer-review process, introduced over a thousand years ago in Syria and fully formalized by the Royal Society of London during 1665-1752, is an integral part of quality control in publishing articles and in awarding research grants. However, there are many lingering problems, which include: 1) anointed experts, 2) blind peer reviews, 3) delays, 4) orthodoxy, 5) bias, 6) groupthink, 7) Peer rejection of ideas (including Nobel-Prize winners), 8) inconsistency, 9)  politics, 10) fake peer review and plagiarism, 11) “Sham peer review” in the U.S. medical community, 12) settling old scores, 13) online publications, 14) acknowledgements, 15) controversies in geological sciences, and 16) imbalance of peer reviewers in the biomedical research. Transparency, which is the underpinning trait of science journalism, is lost in the secrecy of blind peer review. Under the blind peer review, there are at least eight examples of scientific papers that were rejected before going on to win a Nobel Prize.  Furthermore, there are 33 striking cases of peer rejection in science, including the notorious theory of “continental drift” by Alfred Wegener. My own examples of papers in process sedimentology and petroleum geology show that the same manuscript was rejected by one journal, but was accepted by another, suggesting that the blind peer review is obsolete. A solution is to adopt an Open Peer Review (OPR). Barring an open peer review, an alternative path is to publishing the entire peer-review comments and recommended decisions of all reviewers (anonymous and identified) at the end of a paper. This practice not only would force the anonymous reviewer to be objective and accountable but also would allow the entire peer-review process to be transparent.