bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Penggantian Mesin Hot Press dengan Menggunakan Metode Equivalent Uniform Annual Cost (EUAC) di PT Xyz
Authors: Anestesia Purba Arini , Sunani Avi , Prabowo I Putu Deny Arthawan Sugih
Published: March 2023

PT Xyz adalah perusahaan industri yang memproduksi Upright Piano dan Grand Piano. Untuk memenuhi target produksi perusahaan masih terkendala dengan permasalahan pada kehandalan atau kondisi mesin. Dari hasil penelitian yang dilakukan pada bagian produksi, salah satu mesin yang digunakan yaitu mesin Hot Press tipe KU-HPD 66 memiliki umur ekonomis 8 tahun namun sudah digunakan selama 10 tahun melewati umur ekonomisnya sehingga sering mengalami kerusakan pada saat kegiatan produksi berlangsung seperti sil bocor, oli muncrat, sehingga dapat menghambat target produksi yang ingin dicapai oleh perusahaan dan menningginya biaya perawatan pada mesin, biaya perawatan mesin tersebut berupa penggantian suku cadang. Dari permasalahan tersebut, diketahui apa saja biaya-biaya yang mempengaruhi serta pemakaian mesin Hot Press lama masih dapat diteruskan atau sudah harus dihentikan penggunaannya. Adapun pendekatan yang digunakan untuk memecahkan masalah tersebut yaitu analisis penggantian mesin dengan metode equivalent uniform annual cost (EUAC). Perhitungan depresiasi dengan metode garis lurus guna mengetahui besarnya depresiasi tahunan dan total depresiasi. Dari hasil penelitian, perhitungan dan analisis yang dilakukan penulis dengan data yang diperoleh dari perusahaan, dapat disimpulkan bahwa mesin Hot Press tipe KU - HPD 66 lama jika dilakukan perbaikan secara keseluruhan (overhaul) dengan umur teknis 4 tahun pada tahun 2021 dengan biaya tahunan bersih sebesar Rp 363.531.666,- yang menunjukkan bahwa biaya mesin Hot Press tipe KU-HPD 66 lama (defender) lebih tinggi dibandingkan dengan mesin Hot Press tipe KU-HPD 566 baru (challenger) yaitu Rp 331.537.186,- dengan umur teknis 8 tahun. Dari biaya operasi untuk mesin Hot Press lama lebih besar dibandingkan dengan mesin Hot Press baru sebaiknya perusahaan melakukan penggantian mesin Hot Press baru (Challenger).
The ethics of deprescribing in older adults
Authors: Zyryanov SK , Baibulatova EA
Published: March 2023

Older adults consume a disproportionate amount of medicinal products. Polypharmacy may increase the risk of adverse effects, result in poor medication adherence and unfavorable outcomes. There is considerable evidence that older adults are prescribed unnecessary or excessive medications. Treatment outcomes can be improved owing to controlled discontinuation of medicinal products. The deprescribing principles include analysis of all current prescriptions, detecting the medications that must be discontinued, dosage replacement or reduction, discussing the deprescribing regimen together with a patient, patient’s control and support. Clear comprehension of indications and benefit of the conducted pharmacotherapy, objective risk assessment by prescribing physicians and by a patient, and a deliberate deprescribing plan can improve treatment outcomes of the elderly.
An analysis of team projects outcomes from student and instructor perspectives in online computing degrees
Authors: Olaniyi Nkaepe , Millward Douglas , Peoples Cathryn
Published: March 2023

One of the core aims of higher education degrees is to provide an environment for students to acquire essential skills that will help them in the workplace. Team working is one of those essential skill and it is also one that experience and research show is regularly resisted by students. This resistance can become even more amplified when the degree is delivered online, although some have pointed out that a good team provides much-needed community spirit and support in such environments. The purpose of this study is to review the delivery of a team assessment format that has been specifically designed for the online environment. The results presented provide insight into the student’s perspective on the delivery as well as the reflections of the instructors involved in the delivery. The overall outcome is positive for both parties and provides further guidance on implementation to ensure the pedagogical design continues to be viable. This includes insights into team composition, instructor involvement, and peer review scoring formats.
Implicações do Consumo Abusivo de Esteroides Anabolizantes na Saúde Sexual e Reprodutiva Masculina
Authors: Santos Joana , Pereira Bruno Jorge
Published: March 2023

O consumo de esteroides anabolizantes tem crescido exponencialmente nos últimos anos. O seu consumo crónico acarreta inúmeras consequências a nível do sistema cardiovascular, endocrinológico, psicológico e genitourinário.Opresente trabalho pretende fazer uma revisão sistemática sobre os efeitos nefastos dos esteroides anabolizantes na fertilidade masculina e na função sexual, nomeadamente no que concerne à disfunção erétil, ejaculatória e distúrbio da libido. Estas substâncias são frequentemente vendidas de forma ilegal em plataformas de comércio eletrónico sem prescrição médica e, por isso, é imperativo tentar solucionar o problema tanto a nível do controlo da venda livre, como a nível de terapêuticas para reverter ou melhorar os efeitos colaterais nos consumidores.
A NEW APPROACH TO CHEMISTRY TEACHERS EDUCATION AT PEDAGOGICAL UNIVERSITY OF CRACOW
Authors:   Uniwersytet Pedagogiczny w Krakowie, Cieśla Paweł , Nodzyńska Małgorzata ,   Uniwersytet Pedagogiczny w Krakowie
Published: March 2023

The paper descrribes the proposal of a new approach to the construction of a studies that prepare students to become a chemistry teachers that is realised at Pedagogical University of Cracow. The need to prepare a new study program is discussed, as well as its relationship with the mission of the University. Preparation for the teaching profession requires an interdisciplinary approach. Someone who will be an excellent chemist, biologist or mathematician will not necessarily be a very good teacher. Therefore, it is not enough to equip the student with knowledge and skills in the substantive field, in this case chemistry, but also psychological, pedagogical and methodological preparation. Therefore, the proposed studies at the Pedagogical University have been prepared in such a way as to meet these requirements. The objectives of the studies and the profile of the graduate are presented, as well as the methods of verifying the learning outcomes. Also the learning process is descibed.
PBL AS A METHOD USED IN PRE-SERVICE CHEMISTRY TEACHER TRAINING
Authors:   Uniwersytet Jagielloński, Maciejowska Iwona
Published: March 2023

Pre-service teacher training in Poland is a subject to constant system changes. The main accusation is a domination of theoretical knowledge, and insufficient practical skills of future teachers. One of the solutions available to an academic teacher who cannot change the fixed standards imposed by the ministry may be the use of appropriate teaching and learning methods. The use of Problem Based Learning, which by definition simulates situations typical of professional work, may be particularly useful. At the Faculty of Chemistry, PBL was introduced in the course “Basics of education” (Podstawy dydaktyki ogólnej) both in the form of onsite and in the form of distance learning. Both forms of the course: on-site and remote were subject to evaluation. The research covered: products of student groups work (boards), group and individual student surveys, self-and peer- assessment sheets. Advantages and limitations of both forms of conducting classes were determined, recommendations were made for the next year of education. One of the main conclusions is the use of blended learning strategies. Work in a remote form is particularly useful when the course is attended by a larger number of students (over 12) divided into smaller subgroups, in which each student is required to present the learning effect that (s)he worked individually between classes on. However, meeting in a room, definitely helps in getting to know and engaging the group to work.
Fondo de Infraestructura Social Estatal en México: Un análisis de política pública
Authors: Ayvr Campos Francisco Javier , Silva Trigueros Jorge
Published: March 2023

El presente documento tiene como finalidad analizar el Fondo de Infraestructura Social Estatal, herramienta utilizada por el Estado mexicano para reducir la pobreza extrema y el rezago social, mediante la construcción de infraestructura social básica. Posteriormente, con base en indicadores socioeconómicos recolectados entre los años 2010 y 2020, se analizó la problemática a partir de la Metodología del Marco Lógico, única aceptada para el diseño de políticas públicas en México, proponiéndose diversas adecuaciones al fondo, así como de las competencias de cada uno de los niveles de gobierno involucrados, debe realizar para mejorar el impacto sobre los indicadores que se atienden. La periodicidad de la distribución de recursos, la publicación del marco normativo de forma clara y oportuna, la profesionalización e innovación, así como la rendición de cuentas, resultan deseables en la gestión del fondo.
TANQUES DE ARMAZENAMENTO DE COMBUSTÍVEIS: CRITÉRIOS DE PROJETO VISANDO A REDUÇÃO DE EMISSÕES DE COMPOSTOS ORGÂNICOS VOLÁTEIS (COV)
Authors: Kolicheski Mônica Beatriz , Castilho José Augusto , Kawano Mauricy
Published: March 2023

Os parques de tancagem de hidrocarbonetos geram impactos ambientais devido às emissões fugitivas de COV oriundas dos tanques, pois esses são projetados basicamente com critérios econômicos. As emissões de COV geram problemas de poluição do ar. Com o objetivo de estabelecer critérios ambientais para o desenvolvimento de projetos de tanques de armazenamento, visando a redução das emissões, foram estimadas as emissões de COV pelo software Tanks para três tipos de tanques de armazenamento de hidrocarbonetos. A configuração, distribuição de tancagem, cor e integridade da superfície para três produtos (gasolina, diesel e petróleo) foram avaliadas. O estudo indicou que a aplicação dos critérios ambientais resultam no aumento da eficiência de armazenamento, redução das perdas e minimização da poluição do ar. O uso dos critérios no dimensionamento dos tanques pode reduzir em torno de 50% as emissões de COV, dependendo do tipo de hidrocarboneto armazenado. Os critérios propostos na distribuição de volumes permitiriam reduções de até 80% e o revestimento adequado de até 40% das emissões de COV.
A POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS E A REDUÇÃO DE IMPACTOS AMBIENTAIS NEGATIVOS: VIABILIZANDO CIDADES E COMUNIDADES SUSTENTÁVEIS
Authors: Guimarães Monteiro Trigo Aline , Aires Trigo José , Gomes Rosa Maruyama Úrsula , Monteiro da Silva Melo Vinícius
Published: March 2023

O objetivo deste trabalho é discutir como os objetivos da Política Nacional de Resíduos Sólidos (PNRS) contribuem para o alcance dos Objetivos de Desenvolvimento Sustentável (ODS), que tratam da redução per capita do impacto ambiental negativo das cidades. O levantamento realizado pela Associação Brasileira das Empresas de Limpeza Pública e Resíduos Especiais, em sua última publicação, em 2021, sobre a geração de resíduos sólidos urbanos no Brasil, mostra que, em 2020, a média diária alcançou cerca de 226 mil toneladas, totalizando aproximadamente 82,5 milhões de toneladas. Esses números são ainda mais graves se considerarmos que, desde a implantação da PNRS em 2010, a destinação inadequada dos resíduos coletados não mudou muito: 43,2% (2010) e 39,8% (2020) terminando em lixões ou aterros controlados, que, tecnicamente e ambientalmente, não são as opções adequadas. A pesquisa qualitativa, exploratória e documental busca investigar diferentes contribuições científicas por meio de um estudo comparativo entre PNRS e ODS. Observou-se que todos os quinze objetivos da PNRS estão alinhados a pelo menos um ODS. Em 2021, a criação da Agenda Nacional de Qualidade Ambiental Urbana representou um esforço significativo nessa direção. Portanto, este trabalho pretende contribuir com evidências e reflexões sobre o alinhamento entre PNRS e ODS. Além disso, a contribuição social busca convergir os esforços do governo e da sociedade civil para garantir os direitos humanos, eliminar a pobreza, preservar o meio ambiente e estimular o desenvolvimento de uma sociedade mais equânime.
Karakteristik Rumah Tangga Miskin Ektrem di Propinsi Jawa Barat
Authors: Suryadi Dudi
Published: March 2023

Tujuan dari penelitian ini adalah untuk mengetahui karakteristik kemiskinan ekstrem dan faktor yang mempengaruhinya di Propinsi Jawa Barat. Data yang digunakan dalam penelitian ini merupakan data mikro SUSENAS bulan Maret 2020, yang dikeluarkan oleh BPS. Metode analisis yang digunakan adalah regresi logistik biner. Variabel bebas dalam penelitian ini yaitu karakteristik rumah tangga yang terdiri dari jumlah anggota rumah tangga, kepemilikan asuransi kecelakaan, kepemilikan sertifikat rumah, serta tempat tinggal rumah tangga. Sedangkan variabel bebas lainnya terkait dengan karakteristik kepala rumah tangga, terdiri dari jumlah jam kerja, usia, pendidikan, status pernikahan, jenis kelamin, kemampuan baca tulis, penggunaan teknologi dan pemanfaatan internet. Sedangkan yang menjadi variabel terikatnya yaitu rumah tangga miskin ekstrem. Berdasarkan hasil penelitian, secara statistik jumlah anggota rumah tangga, kepemilikan asuransi kecelakaan, kepemilikan sertifikat rumah, tempat tinggal rumah tangga berpengaruh terhadap kemiskinan ekstrem. Karakteristik kepala rumah tangga yang terdiri dari jumlah jam kerja, usia, pendidikan, status pernikahan, jenis kelamin, kemampuan baca tulis, kepemilikan handphone serta akses terhadap internet secara signifikan berpengaruh terhadap rumah tangga miskin ekstrem. Oleh karena itu, untuk mengentaskan kemiskinan khususnya di Jawa Barat, diantaranya kebijakan pengendalian penduduk, penyediaan jaminan sosial, kemudahan pengurusan kepemilikan sertifikat rumah, serta pemeratan pembangunan hingga wilayah pedesaan. Sedangkan kebijakan pengentasan kemiskinan ekstrem dikaitkan dengan karakteristik KRT adalah menyediakan pekerjaan yang layak (decent jobs), peningkatan kapasitas rumah tangga melalui pendidikan dan pelatihan, serta memberikan peluang dan hak yang sama bagi perempuan untuk memasuki pasar tenaga kerja dengan upah yang sesuai.
Identifikasi Pengukuran Indeks Kerentanan Sosial Daerah Rentan Bencana Di Jawa Timur
Authors: Sudirman Sudirman , Ambarwati Arie , Lubis Lunariana
Published: March 2023

Letak geografis dan topografi Indonesia yang berada di cincin api menempatkan Indonesia pada risiko tinggi mengalami bencana alam seperti gempa bumi, letusan gunung berapi, tsunami, banjir dan tanah longsor. Bencana selalu mengakibatkan kerugian harta benda dan manusia serta seringkali menyebabkan kehancuran komunitas tertentu. Demografi multietnis di Jawa Timur, provinsi dengan pertumbuhan tinggi terbesar kedua di Indonesia, memungkinkan terjadinya konflik sosial yang dapat mengakibatkan bencana dan kerugian material dan tidak berwujud. Penelitian ini bertujuan untuk mengamati dan menganalisis faktor-faktor yang mengukur nilai indeks kerentanan sosial di daerah rawan bencana di Jawa Timur. Dalam penelitian untuk mengukur faktor indeks kerawanan sosial di daerah rawan bencana di Jawa Timur digunakan metode analisis data statistik deskriptif kuantitatif yang disebut analisis faktor dan analisis skoring. Hasil survei mengungkapkan empat faktor utama yang menentukan tingkat kerentanan sosial lokal di delapan kabupaten/kota. Faktor utama adalah faktor I: komposisi rumah tangga berkebutuhan khusus dan berpendidikan rendah (cacat, rasio usia, pendidikan dasar), faktor II: status sosial (status pekerjaan, tingkat bantuan sosial, status perkawinan), faktor III: Faktor ekonomi. Status dan Pendidikan Menengah (Pendapatan, Pendidikan Menengah, Faktor IV : Pendidikan Tinggi (Perguruan Tinggi dan SMA)) Keempat faktor dominan inilah yang kemudian digunakan untuk menghitung kerawanan sosial regional di delapan kabupaten/kota di Jawa Timur.
ASSESSMENT OF HEMATOLOGICAL RELATIONS IN PATIENTS WITH DIABETIC FOOT SYNDROME
Authors:   Mogilev Regional Clinical Hospital, Mogilev, Belarus, Stavchikov E. L. , Zinovkin I. V. ,   Mogilev Regional Clinical Hospital, Mogilev, Belarus, Marochkov A. V. ,   Mogilev Regional Clinical Hospital, Mogilev, Belarus
Published: March 2023

Background. Type 2 diabetes mellitus (DM 2) is one of the significant medical, social and economic problems in the Republic of Belarus due to the high prevalence and development of severe complications. The need to predict and prevent diabetic foot ulcer (DFU) is becoming one of the most urgent clinical tasks, which requires the introduction into practice of indicators available for routine determination that can predict the course of DFU. Objective. To study the prognostic significance of the hematological ratio in assessing the risk of occurrence and clinical course of DFU. Material and methods. A non-randomized study was performed, in which 74 patients participated. The entire sample was retrospectively divided into 2 groups: patients with DM 2 (control group, n=43) and patients with DM 2 who have DFU (experimental group, n=31). Venous blood was taken on an empty stomach to determine the level of neutrophils, lymphocytes, platelets, glycated hemoglobin (HbA1), neutrophil-lymphocytic ratio (NLR) and plateletlymphocytic ratio (PLR) were calculated. Results. It was revealed that the patients of the control and experimental groups did not differ in gender, age, body mass index (BMI), absolute number of lymphocytes and HbA1 level. It was found that in patients of the control group, the level of neutrophils, platelets, as well as NLR and PLR in the blood was statistically higher (p<0.05). Spearman's correlation analysis showed that in the control and experimental groups, all the studied indicators do not correlate with the NLR. In the experimental group, the BMI indicator negatively correlates with PLR (r=0.52; p<0.05), and Hba1c positively correlates with aphids (r=0.555; p<0.05). The NLR was equal in patients of category 1-3 according to the classification of DFU of the University of Texas (N=15) – 2.06 (1.55; 2.21) nmol/l, in patients of category 4-6 (N=16) – 4.33 (3.28; 5.73) (p<0.05). The PLR in patients with the smallest category was 95.88 (86.04; 108.63) nmol/l, in patients with the largest category – 174.98 (150.23; 210.64) (p<0.05). The area under the ROC curve for the indicators of NLR and PLR was the largest – 0.761 and 0.708, respectively. Conclusions. 1. The content of neutrophils and platelets in the blood, NLR and PLR was significantly higher in patients with DFU compared with patients who have DM 2 without DFU. 2. In patients with DM2 complicated by DFU, the indicator PLR negatively correlates with BMI and positively correlates with HbA1. 3. The NLR and PLR in patients with DFU increase with an increase in the risk of possible amputation of the lower limb during the year. 4. In patients with DFU the NLR and PLR have the great diagnostic value as a laboratory criterion of DFU.
THE INFORMATIVENESS OF TRADITIONAL MICROBIOLOGICAL ANALYSIS IN SEPSIS IN PATIENTS WITH NEURO-RESUSCITATION PROFILE
Authors:   Grodno State Medical University, Grodno, Belarus, Kiryachkov Ju. Ju. ,   Federal Scientific and Clinical Center of Reanimatology and Rehabilitation, Moscow, Russia, Yakubtsevich R. E. ,   Grodno State Medical University, Grodno, Belarus, Puzin S. N. ,   Federal Scientific and Clinical Center of Reanimatology and Rehabilitation, Moscow, Russia, Usolceva N. I. ,   Federal Scientific and Clinical Center of Reanimatology and Rehabilitation, Moscow, Russia
Published: March 2023

Background. The existing routine methods of identification of microbes in various biological environments of the body have not led to a radical improvement in the target selection of antimicrobials and the outcomes of septic conditions. The purpose of the study: to analyze the effectiveness of standard microbiological studies in sepsis in patients with brain damage of various origins. Material and methods. A retrospective cohort study included 40 patients (male – 23, female – 17, average age – 50.43±2.84 years) neuro-resuscitation profile. The importance of the most important microbiological patterns of biological media in survived and deceased patients from sepsis has been studied. Results. Acinetobacter baumani, Escherichia coli in urine, Providencia stuartii in tracheobronchial aspirate were detected only in deceased patients, which the presence of these microorganisms can be considered adverse prognostic factors in sepsis and septic shock. Conclusion: A decrease in the clinical significance of the traditional method of verification of microbiological cultures in sepsis was revealed.
INFLUENCE OF LOW LEVEL LASER THERAPY ON IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH PHLEGMON OF THE MAXILLOFACIAL REGION AND NECK
Authors:   Grodno State Medical University, Grodno, Belarus, Cherniak L. A. , Harelik P. V. ,   Grodno State Medical University, Grodno, Belarus, Haretskaya M. V. ,   Grodno State Medical University, Grodno, Belarus, Sheibak V. M. ,   Grodno State Medical University, Grodno, Belarus
Published: March 2023

Background. The problem of treatment of phlegmon of the maxillofacial region and neck remains one of the most urgent problems of maxillofacial surgery. Aim. To determine the degree of influence of local Low Level Laser Therapy (LLLT) on the quantitative and functional characteristics of immunocytes and humoral factors in peripheral blood and lavage fluid in phlegmon of the maxillofacial region and neck. Material and methods. We have examined and treated 60 patients with phlegmon of the maxillofacial region and neck. Of these, 30 people made up group 1 – traditional treatment and 30 people were included into group 2 (traditional treatment supplemented with local LLLT). Also, 12 practically healthy individuals were examined to determine the regional norm of the selected indicators (control group). The total number of leukocytes and their subpopulations were determined in the blood and lavage fluid, immunophenotyping of lymphocytes was performed using monoclonal antibodies (CD3+, CD4+, CD8+, CD16+, CD19+, CD25+, CD95+), determination of the phagocytic index (PhI) and phagocytic number (PhN), the study of hemolytic complement activity (CH50), the presence of circulating immune complexes (CIC) and the level of immunoglobulins (Ig) of classes M, A, G. Results. Weekly local exposure of LLLT contributed to a decrease in leukocytes and neutrophils in the blood with an increase in their functional activity (PhN), an increase in the number of lymphocytes, levels of IgM, IgG, while reducing CH50 in blood serum. In the lavage fluid under the influence of LLLT, a decrease in leukocytes, neutrophils, activation of phagocytosis, an increase in lymphocytes due to the number of CD3+ and CD4+ T-lymphocytes, a decrease in CD8+ of cytostatic T-lymphocytes, CD25+ activated T- and B-lymphocytes, CD95+T- and B-lymphocytes, decrease in CH50, IgM level and increase in IgG were revealed. Conclusion. Comprehensive treatment of patients with phlegmon of the maxillofacial region supplemented with LLLT has a modulating effect on cellular and humoral immunity factors by enhancing the local immune response.
AXIOMATIZATION OF INTUITIONISTIC LOGICS DEFINED BY SMALL FRAMES
Authors: Башмаков С.И. , Голованов М.И.
Published: March 2023

Исследуются табличные интуиционистские логики, семантически характеризуемые фреймами Крипке глубины не более 3 и ширины не более 2. Дана аксиоматизация основных таких логик, построена порожденная ими решетка. Известные методы позволяют, используя данные аксиоматизации, задать аксиоматику остальных логик решетки.

In this paper, we study the tabular intuitionistic logics semantically characterized by the Kripke frames of the depths no greater than 3 and widths no greater than 2. The axiomatization of such basic logics is given; the lattice generated by them is constructed. Known methods make it possible, using given axiomatization, to specify the axiomatic of the remaining logics from the lattice.
THE INVERSE PROBLEM OF RECOVERING A LEADING COEFFICIENT IN THE TWO–DIMENSIONAL HEAT EQUATION
Authors: Цыбиков Б.Н.
Published: March 2023

Рассматривается обратная задача восстановления старшего коэффициента, не зависящего от одной из пространственных переменных y, в двумерном уравнении теплопроводности. В качестве условий переопределения рассматриваются значения решения на сечении области плоскостью $y = 0$. Решение ищется в классе функций, Фурье-образ которых по переменной y имеет компактный носитель по двойственной переменной. Получены условия существования и единственности решений в данном классе.

We consider the inverse problem of recovering a leading coefficient independent of one of the spatial variable y in the two-dimensional heat equation. The overdetermination data is the values of the solution on the cross-section of the domain by the hyperplane $y=0$. The solution is sought in the class of functions whose Fourier image in the variable y is compactly supported in the dual variable. Existence and uniqueness conditions of the solution to this problem in this class are established.
МОДЕЛИРОВАНИЕ ДИНАМИКИ ФОРМЫ ПЛОСКОГО ТЕЛА ИЗ КОВКОГО МЕТАЛЛА ПРИ ИЗОТРОПНОЙ БОМБАРДИРОВКЕ ЧАСТИЦАМИ ПЕСКА
Authors: Матвеев А.И. , Осипов Д.А. , Осипов Д.Р. , Яковлев Б.В.
Published: March 2023

Первоначальная форма зерен золота, встречающихся в природе, в большинстве случаев имеет форму плоской пластины (чешуйчатую форму). Поэтому при пневмосепарации часто наблюдается торовидная форма кусков золота. При сепарировании форма зерен в виде тора считается наиболее эффективной, тем самым актуальна задача расчета времени образования торовидной формы куска золота. В настоящей работе рассматривается эволюция деформируемой поверхности плоского диска из ковкого металла при изотропной бомбардировке его поверхности мелкими частицами. Разработана математическая модель эволюции поверхности диска. Получено дифференциальное уравнение, описывающее изменение деформируемой поверхности круглого диска, которое решается численным методом Рунге–Кутты. Решение уравнения описывает деформируемую поверхность тела в зависимости от времени. Из результатов исследования следует, что наиболее устойчивой торовиднойформы, при которой деформируемая поверхность достигает максимального значения, тело достигает достаточно быстро, затем наступает более медленное изменение поверхности до шаровидной формы. Оценено время образования торовидной формы диска при определенных параметрах исследуемой системы. Результаты могут быть использованы при разработках более точных моделей эволюции плоских тел при бомбардировке их поверхности мелкими частицами.
Obesity, Associated Diseases and Potential Complications: Prevention and Treatment Strategy through Nutritional Intervention Combined with Physical Activity
Authors:   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, LP Souza , HHO Alves ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, LC Santos ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, L Fernandes ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, R Manoel ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, RP Souza , AC Levada-Pires ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, POF Martins ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, R Gorjao ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil, MF Cury-Boaventura ,   Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Brazil
Published: March 2023

Obesity modulate the production of hormones and adipokines such as leptin, adiponectin, and resistin, thereby favoring the development of chronic Noncommunicable Diseases (NCDs). Nutritional intervention is a strategy used for its prevention and/or treatment. We analyzed the benefits of a nutritional intervention program combined with the practice of physical activity on body composition and NCD markers. Eighteen people with a mean age of 58 ± 8 years, weight of 73.68 ± 16.57 kg, Body Mass Index (BMI) of 28.30 ± 4.88 kg/m2, Waist Circumference (WC) of 95.72 ± 13.57 cm, waist/hip ratio of 0.80 ± 0.07, and body fat percentage of 35.22% ± 4.84% who practiced aquatic aerobics and/or swimming participated in a six-month nutritional intervention program with weekly meetings. Data collection was performed before and after the intervention. We evaluated BMI, body fat percentage, WC, and hip circumference as well as the levels of leptin, resistin, adiponectin, and insulin. Nutritional intervention combined with physical activity contributed to a reduction in weight by 1.47% (p < 0.05), BMI by 1.32% (p < 0.05), and the plasma concentration of leptin by 18.04% (p < 0.05) and resistin by 8.70% (p < 0.05). There was no significant change in the hormones adiponectin and insulin. Total cholesterol decreased by 22% (p < 0.01) and low-density lipoprotein cholesterol (LDL-c) by 51.80% (p < 0.0001). During the follow-up period we observed a reduction in weight, BMI, leptin, resistin, total cholesterol, and LDL-c. Therefore, we conclude that changes in eating habits along with the performance of physical activity assist in the treatment of overweightness and obesity and, thus, prevent associated diseases.
Utilization of Moringa Oleiferaleaves to Fortifyrice: Effect Onrda of Adult and Pregnant Women
Authors:   Department of Food and Nutrition, Baba saheb Bhimrao Ambedkar University (A Central University), India, SH Yadav , S Mishra ,   Department of Food and Nutrition, Babasaheb Bhimrao Ambedkar University, A Central University, India
Published: March 2023

The present study aims to utilize the staple food of over half of the world population, that is rice, which is a brilliant source of energy and good for Celiac, and fortifying it with Moringa oleifera caries potential to enhance and improve overall nutrient availability. Products like Ready- to- Cook (RTC) Idli & Dhokla mix were fortified with 5 and 10 % moringa leaves powder respectively were analyzed. The proximate and nutrient composition like moisture, ash, fibre, protein, fat and carbohydrate of rice, moringa leaves and fortified mixes were analyzed. The micronutrients like calcium, phosphorus, iron and vitamin C were analyzed and compared with RDA of adult and pregnant women as per % Daily Value (DV). The elevation of % DV by 1.5% & 3% in calcium, 2.5% & 3% in potassium, 5.2% & 10.4% in vitamin C and 4.2% & 9.5% (adult), 2.9% & 6.6% (pregnant women) with respect to standard sample was observed respectively with elevation of 5% and 10% fortification moringa leaves powder. The products were packed in different packaging materials like Glass, LDPE, HDPE, aluminum laminated HDPE and storage life was analyzed for the period of 60 days. For storage life parameters like weight, moisture content, water absorption capacity and overall acceptability were taken into consideration.
Evaluation of Cold Plasma Effect on Shelf Life, Physicochemical and Organoleptic Properties of Cucumber (Cucumis Sativus Var. Negin)
Authors:   Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran, H Yarabbi , S Roshanak ,   Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran, F Hadizadeh ,   Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran, F Shahidi ,   Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran, FT Yazdi ,   Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran
Published: March 2023

Non-thermal plasma is a new technique to reduce the microbial load in fresh fruits and vegetables, which can decontaminate the surfaces of fresh food products. This research used the atmospheric pressure jet discharge plasma of argon gas to treat cucumber samples. The treatments included two power levels (voltage of 17 volts with a current intensity of 2.66 amps and voltage of 10 volts with a current intensity of 0.86 amps) and four-time levels of plasma application (0, 2, 4, and 6 minutes) on the surface of cucumber samples. Cucumbers’ microbial, qualitative, and sensory characteristics were measured after plasma application and during storage at 250C in three periods, the first, fifth, and tenth days after plasma application. The results of the microbial analysis in plasma-treated samples with the machine’s high power showed a decrease of 2.59 logarithmic cycles in the total count and 1.388 logarithmic cycles in mold and yeast. No significant difference was observed between the tissue hardness and color indices of the treated samples immediately after plasma application and the corresponding values of the control sample in both powers. Examining the quality indicators of cucumber samples during storage showed the superiority of the treated samples compared to the control samples. The sensory evaluation of cucumber samples indicated that plasma had no adverse effect on the sensory characteristics of cucumbers. The aroma characteristics and general acceptability of the plasma-treated samples were significantly better than the control samples during the storage period. Based on the results, cold plasma is a new method for food processing. Due to its non-thermal nature, this technique can be a suitable alternative to other techniques used for the decontamination, pasteurization, and sterilization of food products, especially heat-sensitive products.
Phytochemicals as Potential Anti-Alzheimer’s Agents- An In-Silico Evidence
Authors:   Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India, D Pandey , T Pal ,   Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India, A Sharma ,   Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India
Published: March 2023

Alzheimer’s Disease is a prominent neurodegenerative disorder affecting the age group 60 and above. Cholinergic hypothesis, amyloid β cascade, oxidative stress is some of the known etiologies of marked importance to name a few. We have undertaken a computational analysis where fifteen phytochemicals were selected. These natural molecules were studied and analysed against acetylcholinesterase, butyrlcholinesterase, BACE and amyloid β monomer and protofibril. The binding affinities of Genistein, Huperzine A, kaempferol, Methyl quercetin, Paclitaxel and Withinolide A against AChE and BuChE enzymes were found to be -7.7 to -8.6 Kcal/mol, respectively. Various phytochemicals like Genistein, kaempferol, Piceatannol, Ginkgolide B, Methyl quercetin and Withinolide A were found to bind the BACE-1 enzyme with the binding affinities of -6.7 to -7.9 Kcal/mol. All the phytochemicals experienced efficient binding towards Aβ monomer and Aβ protofibril. Withinolide A was found to bind all the PDB’s efficiently with binding affinity of -8.4, -8.9, -7.7, -6.6 and -6.8 Kcal/mol against AChE enzyme, BuChE enzyme, BACE-1 enzyme, Aβ monomer and Aβ protofibril, respectively as a result it can be carried forward for the further preclinical and clinical studies.
Immune Biomarker Combinations for Diagnosis Monitoring of Latent Tuberculosis Infection
Authors:   Centro de Estudios Cientiificos y Tecnologicos No. 18, Instituto Politecnico Nacional, Zacatecas, 98160 Zacatecas - Mexico, Zaida Araujo , Ernesto Lopez-Ramos Juan ,   Laboratorio de Inmunologia de Enfermedades Infecciosas, Instituto de Biomedicina Dr, Jacinto Convit, Universidad Central de Venezuela, San Jose, Apartado 4043, Caracas 1010A, Caracas DC - Venezuela, Antonio Enciso-Moreno Jose ,   Facultad de Química, Universidad Autónoma de Querétaro, México, Henri de Waard Jacobus ,   Laboratorio de Tuberculosis, Instituto de Biomedicina “Dr. Jacinto Convit”, Universidad Central de Venezuela, Venezuela, Bruno Rivas-Santiago ,   Unidad de Investigación Biomédica de Zacatecas, Instituto Mexicano del Seguro Social, México, Magnolia Vanegas ,   Department of Molecular Biology and Immunology, Fundación Instituto de Inmunología de Colombia (FIDIC), Colombia, Alfonso Patarroyo Manuel ,   Department of Molecular Biology and Immunology, Fundación Instituto de Inmunología de Colombia (FIDIC), Colombia
Published: March 2023

Objective: Global Tuberculosis (TB) eradication efforts must also focus on detecting and treating cases of Latent TB Infection (LTBI); persons with LTBI can progress to active TB at any time, often many years or even decades after the initial infection, thereby serving as a source of new infections. Methods: The aim was evaluated the diagnostic accuracy of the combination of serological host biomarkers that may support the differentiation between LTBI and Non-Infected (NI) individuals. A total of 182 adult Warao Amerindians were included; cases with LTBI (n=103) and Non-Infected (NI) individuals (n=79). The Real-time quantitative PCR (qPCR) was performed on all peripheral blood samples from Warao Amerindians and analyzed transcriptional immune biomarkers (i.e., IFN-γ, CD14, MMP-9, CCR5, CCL11, CXCL9/MIG, and uPAR/PLAUR proteins) under stimulation condition with ESAT-6, CFP10, and TB7.7 Mycobacterium Tuberculosis (Mtb)-antigens. Additionally, Enzyme-Linked Immunosorbent Assays (ELISA) were performed for evaluating host biomarker anti-synthetic peptides (5 ESAT-6 and 17 Ag85A synthetic peptides) covering Mtb antigen sequences. Results: The approach’s diagnostic information was compared using Receiver Operating Characteristic (ROC) curves. The ROC analysis revealed high biosignature discriminative ability for the relative gene expression of MMP-9 high levels (AUC=0.799 ± 0.071: 0.640 - 0.917, 95% CI), p < 0.002) between LTBI and NI; additionally IgG anti-synthetic peptide; ESAT-6 P-12037 (AUC=0.640; 0.545-0.735 95% CI, p<0.007) allowed differentiation between LTBI and NI or healthy ones. Conclusion: The accuracy of the MMP-9/IgG anti-P-12037 combination could have a high discriminative ability for diagnosing LTBI; such an approach holds promise for further validation.
Recent advances in studying Toll-like receptors with the use of computational methods
Authors: Bzówka Maria , Bagrowska Weronika , Góra Artur
Published: March 2023

Toll-like receptors (TLRs) are transmembrane proteins which recognise various molecular patterns and activate signalling that triggers the immune response. In this review, our goal was to summarise how, in recent years, various computational solutions contributed to a better understanding of TLRs, regarding both their function and mechanism of action. We updated the recent information about small-molecule modulators and expanded the topic towards next- generation vaccine design, as well as studies of the dynamic nature of TLRs. Also, we underlined problems which remain unsolved.
Norfloxacin-arylazopyrazole conjugates as potent light-active antibiotics: design, synthesis and light-assisted reversible control of antibiotic action
Authors: Samanta Subhas , Bhunia Supriya , Kumar Jana Santosh , Sarkar Soumik , Das Arpan , Mandal Sukhendu , Sarkar Kishor
Published: March 2023

Antibiotic resistance has become a threat to mankind in the 21st century. For suppressing the growth of multi-drug resistant bacteria via the photopharmacology approach, photoswitchable norfloxacin-arylazopyrazole conjugates were synthesized, and the photoswitching efficiencies and antimicrobial activities were tested before and after light irradiation. Most compounds exhibited very high to near quantitative isomerization yields with decent cis half-lives (7-28 h) and very high light fatigue resistance. The antimicrobial activity of these norfloxacin analogues was found to be selective to the Gram-positive bacteria. Notably, in comparison to the parent norfloxacin (MIC value 0.8 ug/mL), better efficiencies were displayed by conjugates having para-OMe-substituted arylazopyrazole (both trans and cis states) and para-SMe-substituted arylazopyrazole (cis state only). Some of our compounds in cis state displayed impressive bactericidal activity. Remarkably, a 20-times activity difference between cis and trans isomers was achieved by the visible-light responsive conjugate with para-SMe substitution, which is so far the highest activity difference from any reported photoswitchable antibiotic. Computational GOLD docking poses are in agreement with the experimental data.
Transformation of the Russian Monetary Policy Against the Background of Aggravation of Geopolitical Tensions
Authors:   Financial University,  Moscow, Russia, Pechalova M.Yu.
Published: March 2023

The subject of the study is the transformation of the Russian monetary policy against the background of the aggravation of geopolitical tensions. The relevance of the topic of the article is conditioned by the need to analyze and evaluate the results of the monetary policy pursued by the monetary authorities in the face of unprecedented sanctions pressure of unfriendly countries on the Russian economy in 2014-2022. The purpose of the work is to establish the degree of influence of geopolitical factors and the monetary policy of the Bank of Russia on the exchange rate of the Russian ruble. It is revealed that the key factors determining the exchange rate of the ruble during a special military operation are export-import flows and the geopolitical premium. By means of regression analysis, the dynamics of the geopolitical premium in 2014-2022 is determined. The effectiveness of anti-crisis measures in the domestic currency and stock markets is assessed. The relatively rapid transition of the regulator to a reduction in the key rate after its emergency increase in comparison with the financial crisis of 2014-2015 is emphasized. There is a global trend towards de-dollarization and fragmentation of the world monetary system, as well. changing power relations between global financial centers. It is concluded that in the context of the escalation of the geopolitical conflict, the transformation of the Russian monetary policy took place: the loss of control over a significant part of international reserves forced the monetary authorities to resort to non-market methods of supporting the national currency, which proved to be very successful.
Taylor's Rule as One of the Possible Models for Forecasting Monetary Policy Mechanisms
Authors:   Financial University, Chelyabinsk, Russia, Tsiring D.A. , Lysenko Yu.V. ,   Financial University (Ural Branch), Chelyabinsk, Russia, Malkova T.V. ,   Chelyabinsk State University Miass Branch, Miass, Russia
Published: March 2023

The subject of the study is the processes of transformation of the monetary policy of the Bank of Russia in the new economy, contributing to the introduction of digital innovations. The purpose of the work is to establish, through the application of the Taylor rule, the dynamics of the key rate in the Russian Federation. The main research tools were correlation analysis and economic modeling of the Taylor rule in the EViews program based on empirical data of the Russian Federation. In the course of the study, the main goals, principles and rules of the monetary policy of the Bank of Russia are revealed; the essence and advantages of the Taylor rule; the concept of inflation as one of the significant macroeconomic indicators; the methodology for assessing the parameters of the Taylor rule as a monetary policy tool is clarified. Express diagnostics of the effectiveness of the monetary policy of the Bank of Russia, modifications of the Taylor rule were carried out. A set of measures aimed at improving the quality of assessment of the optimal trajectory of the key rate has been developed.
Valoración económica del servicio ambiental recreativo en el Valle de Piedras Encimadas, Puebla-México
Authors:   Universidad Popular Autónoma del Estado de Puebla, Puebla, México, Higuera Ramírez German Leopoldo , Calatayud Mendoza Alfredo Pelayo ,   Universidad Nacional del Altiplano, Puno, Perú
Published: March 2023

The environment provides welfare to society through different functions that are necessary for the performance of the economy and for the support of life on the planet. But environmental goods are treated as if they were endless. For this reason, the economic valuation of environmental goods and services emerged as a viable technique for the conservation and management of these goods and services. Considering the before exposed, the research research determined the economic value that visitors give to the Piedras Encimadas valley, a place belonging to Camotepec Village in the municipality of Zacatlán in the state of Puebla. The main objective of the investigation was the economic valuation of the recreational environmental service provided on the place already mentioned using the contingent valuation method; The results show that there were 37 protest responses and more than 80% of visitors to the site are willing to pay an entrance fee, the parametric estimation of the willingness to pay was $ 55.50, but it was adopted as a strategy to charge one entrance fee of $ 14 per person. It is concluded that the economic value of the valley for the recreational environmental services that provides is $ 6, 719,757.30 million pesos per year. Visitors tend to value environmental goods and services in a very low way, even though it was mentioned that these goods and services will be improved.
Factores socioeconómicos que determinan la desnutrición crónica infantil en niños menores de cinco años en el Perú – 2014
Authors:   Universidad Nacional del Altiplano, Puno, Perú, Castillo Porto Sonia , Calsin Quispe Giovana ,   Universidad Nacional del Altiplano, Puno, Perú
Published: March 2023

Currently, one of the public health problems facing Peru is the high prevalence of chronic child malnutrition; Which affects the psychomotor and emotional development of the child, limiting access to opportunities, equity and socioeconomic development; the national average rate of chronic malnutrition to 2014 reached 14.6%. The study aims to "Determine the factors that influence chronic malnutrition in Peruvian Children. The study is non-experimental and cross-sectional; for which the ordered probit methodology is applied. The results of the correlational analysis, estimation of the econometric model and the obtaining of marginal effects, conclude that the variables that determine the most important chronic child malnutrition are: housing material type in -7.68%, access to drainage network inside the dwelling in -5.35%, the mother's educational level at -8.33% and the type of residence located in the rural sector at +5.97%, results that are supported by results found by other authors. Therefore, the model shows that children from households with access to health services, better health conditions and higher level of education of the mother are less likely to be malnourished.