bluuebunny/crossref_metadata_2025 huggingface dataset:
Pendekatan Eksperimen Karakteristik Respon Getaran Sistem Two Degree of Freedom dengan Penambahan Independent Dual Dynamic Vibration Absorber
Authors: Susastro Susastro , Riani Novi Indah
Published: June 2019

Vibration is one of the problems that must be reduced in a vehicle. There are many ways to reduce vibration in vehicles, one of them is by adding Dynamic vibration absorber (DVA). While Dual Dynamic vibration absorber (dDVA) is a DVA period that is able to move in the translational direction given to the system to reduce translation vibration and when there is resonance. Translation DVA is an additional type of time used to reduce the vibration of the translation direction. So far there is not much research related to the use of translational DVA to reduce rotational vibrations as well as translation. In this study, a study was conducted related to the use of independent double translational DVA (dDVA) to reduce translation vibrations as well as rotation of the beam. The research was conducted by modeling the system obtained into mathematical equations and simulations were carried out to determine the characteristics of vibrations that arise. In the simulation, one of the DVA periods is placed at the center of the main system period, while the other DVA period is given a change between the center period and the end of the system. The results of the study show that the maximum reduction in translational vibration is 95.51% and occurs when the absorber is placed at the center of the system, while the maximum rotation vibration reduction is 56.62% and is obtained when the system is given with an arm ratio of 1 and zero.
Pengaruh Temperatur dan Waktu Etching Terhadap Karakeristik Fisik dan Mekanik Pelapisan Nikel pada Plastik ABS dengan Metode Elektrolessplating
Authors: Rahman Muhammad Budi Nur , Sunardi Sunardi , Erlangga Muh Budhi , Pratama Muh Finza
Published: June 2019

ABS Plastic (Acrylonitrile Butadiene Stiren) is one type of plastic that is often used because of the many properties that are beneficial to humans. ABS plastic is widely used in engineering, for example in the electronics and automotive fields. But there are still disadvantages of ABS plastic, including low hardness, no friction resistance, and no heat resistance, so surface treatment is needed. Electrolessplating is a coating process that does not use electricity in the coating process. This study aims to determine the effect of temperature and time variation of nickel electrolessplating etching on roughness, wear, hardness, and thickness. The variation in etching temperature is 30; 40; 50; 60; and 70oC and the etching time is 15, 20, 25, 30 and 35 minutes followed by electrolesplating using nickel for 10 minutes. The tests carried out were surface roughness test, disk on block method wear test, hardness using Shore Durometer tool, and layer thickness using micro photos and scanning electron microscopy (SEM). The results showed that the etching process from electrolyplating affected the specimen surface to be coated with nickel metal. The longer the etching time causes the surface to become coarser from 0.435 μm at 15 minutes to 0.949 μm in 35 minutes. The temperature addition of the etching process will increase the surface surface to a temperature of 50oC at 0.499 μm and then drop. Increasing etching time from 15 minutes to 35 minutes will reduce specific wear, from 1.268 x 10-4 mm2 / kg to 0.465 x 10-4 mm2 / kg. Likewise, the etching temperature from 30oC to 70oC decreases the specific wear from 2.10 x 10-4 mm2 / kg to 0.255 x 10-4 mm2 / kg. The addition of etching and temperature etching time does not significantly increase the hardness value of electrolessplating results. Hardness of raw material is 83.5 shore D after coating the hardness value to 84.7 shore D. The electrolessplating process for 10 minutes produces a layer thickness of 1 μm to 2 μm.
Correction of school maladjustment based on interdisciplinary approach
Authors: Balandina O. V. , Bozhkova E. D. , Dvoryaninova V. V. , Katunova V. V. , Konovalov A. A.
Published: June 2019

The article presents the results of the analysis of modern (from 2011 to the present) foreign sources on school maladjustment as an interdisciplinary medical and psychological problem. The urgency of the problem is aggravated against the background of global socio-economic and technological changes that determine the lifestyle and behavior of younger schoolchildren at school and in the family. Taking into account the prospects for the growth of the influence of these factors, the article presents a systematic assessment of modern possibilities for diagnosing, compensating, and correcting disorders to adapt to primary school education for pupils in primary schools based on the results of studying advanced domestic and foreign experience. The analysis showed an increase in the number of modern methods, including with the participation of specialists from various specialties, including psychiatrists, psychologists and teachers, as well as with the active involvement of the families of schoolchildren. It is noted that the validity of the methods is not always at the proper level. Based on the analysis, it was concluded that an interdisciplinary approach is appropriate both in assessing risk and eliminating the causes of school maladjustment, as well as in dealing with its consequences. The prospect of introducing an appropriate approach assumes the project «Healthy Future» on the territory of Nizhny Novgorod.
The characteristics of the contingent of patients sent to the round-the-clock rehabilitation department
Authors: Guseva N. K. , Zubeev P. S. , Berdutin V. A.
Published: June 2019

Recently the financing of the medical stage of rehabilitation has significantly increased due to the funds of compulsory medical insurance; therefore, it became possible to carry out rehabilitation of patients depending on the degree of dysfunction and limitation of life in a 24-hour hospital, day hospital, in outpatient conditions, sanatorium-resort conditions and at home with the involvement of mobile multidisciplinary teams. Meanwhile, important theoretical foundations of rehabilitation began to be forgotten; the goal of rehabilitation measures has always been to obtain a social effect, that is, the restoration of social status, material independence and social adaptation of patients.

The purpose of the study was to identify the characteristics of the contingent of patients sent to the round-the-clock rehabilitation department and determine ways to improve this activity of the medical organization.

Materials and methods. The source of information was the documents of patients who left the hospital, the day care department at the hospital, the day hospital at the outpatient clinic and the hospital at home (f. 066/y-02). 937 hospital cards for 2017 in the rehabilitation department were studied. Data analysis was carried out by the method of tabular summaries, as well as the calculation of extensive and intensive indicators.

Results and discussion. The study showed that the contingent of persons entering the rehabilitation department was composed of people, mostly over 60 years old, who had serious illnesses and injuries.

Conclusions. The inpatient rehabilitation department is very important for the medical organization, since it allows to extend the necessary treatment in case of severe long-term current diseases and to start individual recovery measures in severe elderly patients earlier; elderly people with severe pathology - these are patients of a specialized gerontological department, on the basis of which medical, psychological and social rehabilitation measures should be taken; persons of working age, including those of pre-retirement age, who need complex rehabilitation should be sent to the department mainly.
Divergentno mišljenje u procesu suvremenoga odgoja i obrazovanja
Authors: Kadum Sandra
Published: June 2019

U radu se govori o divergentnom mišljenju kao temeljnoj karakteristici stvaralaštva. Za razliku od konvergentnog mišljenja u kojemu je sve usmjereno ka jednom rješenju, divergentno mišljenje traži najraznovrsnija rješenja razmatrane problemske situacije (problema) i pritom su misli raspršene na vrlo raznolika moguća rješenja. Po svojoj naravi divergentno je mišljenje prevratničko i rušilačko, i kao takvo odstupa od postojećih misaonih pravila i obrazaca, unoseći pritom nered u postojeću misaonu skladnost i red.
Svim učenicima, posebice onima koji mogu i hoće više, onima koji u odnosu prema svojim vršnjacima mnogo toga čine prije, više, brže, uspješnije, bolje i drugačije i koji imaju dosljedno bolja i viša postignuća, u procesu suvremenog odgoja i obrazovanja valja posvetiti posebnu pažnju, što je moguće ostvariti poticanjem divergentnog mišljenja. I stoga se u suvremenom odgoju i obrazovanju, pored znanstveno- konvergentnog oblikovanja mišljenja, mora ostaviti prostora i za divergentno mišljenje.
Guidelines of integrated management solutions: volunteers’ emotional intelligence, intercultural training and work productivity
Authors: Bendaravičienė Rita , Vveinhardt Jolita , Vinickyte Ingrida
Published: June 2019

The relevance of the research presented in the article is based on the results of studies of the last few decades, which show the increasing involvement of volunteers in various social and cultural areas of activities, but it should be emphasized that the involvement of volunteers could be even higher. However, there are considerable challenges in the area of volunteer work management, especially when analyzing the issues of emotional intelligence education, development of intercultural competence to increase work productivity.The aim of this paper is to establish the guidelines of integrated management solutions for the increase of work productivity via the development of emotional intelligence and intercultural training of volunteers.The aim was achieved not only based on the analysis of scientific literature, but also on the results of previous researches carried out by the authors of the article, i.e. a qualitative study interviewing individuals working with volunteers coming to Lithuania from foreign countries (N = 7) and a quantitative study in which the volunteers were surveyed (N = 174).The paper, as a result, presents guidelines for the development of emotional intelligence and intercultural competence based on the concept of the expanding efforts by organizations that send, receive and coordinate volunteers. Four intersecting pairs of criteria for emotional intelligence and intercultural competence have been identified, the integration of which could serve to increase work productivity of volunteers in foreign countries.The value of the article is based on the proposed new idea of integrating emotional intelligence and intercultural competence in order to increase work productivity of volunteers; additionally, it presents their development guidelines for organization management specialists. This study is focused on the integration of emotional intelligence and intercultural competence and identification of interrelated components. For this reason, it would be beneficial in the future to elaborate on the mechanism of how volunteers are prepared for foreign missions with the help of activities by the coordinating, sending and receiving organizations.
Modalização dos sujeitos no processo de formação de leitores: uma análise semiótica do gosto
Authors: Reis Naiane Vieira dos , Silva Luiza Helena Oliveira da
Published: June 2019

Este trabalho investiga o processo de formação de leitores dos acadêmicos em turmas de uma licenciatura em Letras, analisando a competência modal desses sujeitos. Para análise, foram considerados diários de campo produzidos em um estágio em docência na disciplina de letramento literário e dados de uma pesquisa sobre prática de leitura no ensino superior, sendo focalizada a relação dos acadêmicos com a literatura. Embora fossem privilegiadas no curso as discussões teóricas sobre políticas de ensino, observou-se que não foi contemplado o contato com o texto literário no percurso de formação daqueles estudantes. São mobilizadas as contribuições da teoria literária, mais precisamente, as discussões sobre a recepção da leitura pelos sujeitos em diversos contextos sociais, e da semiótica discursiva, mobilizando a sintaxe do nível narrativo para analisar a relação do leitor com o objeto literário e as categorias de interação postuladas pela sociossemiótica. Considerando as competências do sujeito, o leitor quer, mas não sabe, pode ou deve entrar em contato com a literatura. Ainda que o texto literário seja considerado pelos licenciandos como um objeto-valor, o efetivo contato com a literatura acontece em circunstâncias pouco favoráveis à formação do gosto pelo estético, tendo em vista o pragmatismo das demandas da escolarização da leitura, além da idealização do ato de ler, concebido como distanciado da vida real e das necessidades cotidianas. A leitura de literatura vai sendo circunscrita, portanto, como uma habilidade cada vez mais atrelada aos grupos de maior privilégio social. O saber ler não constitui um gostar, sentir prazer na leitura ou apreciar as qualidades estéticas de um texto. Além das discussões teóricas acerca do ensino de literatura, é emergente a necessidade de privilegiar o letramento literário dos professores em formação inicial, tendo em vista que esses sujeitos, futuros mediadores de leitura, em alguns casos, ainda não são leitores.
O funcionamento semântico-argumentativo da modalização epistêmica quase-asseverativa
Authors: Adelino Francisca Janete da Silva , Nascimento Erivaldo Pereira
Published: June 2019

O presente artigo discute o funcionamento semântico-argumentativo da modalização epistêmica quase-asseverativa na construção argumentativa do gênero entrevista de seleção de emprego. Pretendemos saber (i) que recursos linguísticos instauram a modalização quase-asseverativa em entrevistas de seleção de emprego; e (ii) como esses recursos funcionam estrategicamente para gerar orientação argumentativa durante o processo interativo no gênero em estudo. Para tanto, adotamos os pressupostos da semântica argumentativa de Ducrot e colaboradores (1988), juntamente com os estudos da modalização desenvolvidos por Lyons (1977), Cervoni (1989), Castilho e Castilho (1993), Palmer (2001), Neves (2011), Nascimento (2010), Nascimento e Silva (2012), além de outros estudiosos dessa área. A pesquisa assume uma abordagem qualitativa e um caráter descritivo de base interpretativa, já que identificamos e interpretamos os modalizadores epistêmicos quase-asseverativo presentes no corpus, atentando para o seu funcionamento argumentativo.  O corpus é constituído por vinte e duas entrevistas de seleção de emprego gravadas e coletadas em um Centro Universitário localizado em Natal-RN. As análises revelam que, ao fazer uso desse subtipo de modalizador, o entrevistado e o entrevistador demonstram certo distanciamento em relação ao que apresentam em seus discursos. Ademais, esse distanciamento fica marcado pela atenuação impressa no conteúdo da proposição, pela relativização da força da asserção e também pela isenção da responsabilidade com o dito. Além disso, ao usar esse recurso, os locutores não se comprometem com o conteúdo enunciado e, assim, apresentam a proposição em forma de hipótese que depende de confirmação.
As formas de expressão da modalidade volitiva nos discursos do Papa Francisco em viagem apostólica
Authors: Oliveira André Silva , Prata Nadja Paulino Pessoa
Published: June 2019

Este artigo apresenta uma descrição e análise das formas de expressão usadas para a instauração da modalidade volitiva em língua espanhola com base nos discursos do Papa Francisco em viagem apostólica, tendo em vista a proposta tipológica da categoria modalidade apresentada na Gramática Discursivo-Funcional (GDF) e os diversos estudos sobre essa categoria em língua espanhola (SEDANO, 2006; GARCÍA, 2009; TOPOR, 2011; GARCÍA, 2013; e OLIVEIRA, 2017). Os resultados revelam que as construções volitivas foram as mais empregadas (34,2%), seguida pelos usos de verbo pleno (29,1%) e auxiliar modal (24,8%). O emprego majoritário das construções volitivas se dá em virtude do modo subjuntivo, que é o modo verbal prototípico para a instauração das modalizações volitivas relacionadas à manifestação da desejabilidade de potencialização de algum evento volitivo, geralmente, em relação a algo do qual o Sumo Pontífice não teria controle.  Há ainda a proposta de que as orações finais, com a estruturação “para...+para que+subjuntivo”, se prestem à expressão da modalidade volitiva, em que há uma vinculação de um dado estados-de-coisas expresso com base em uma intenção (volição), com prospectividade futura, de caracterização hipotética e para expressar um desejo pessoal do Sumo Pontífice.
Estratégias de indeterminação do sujeito em línguas românicas
Authors: De Oliveira Luciano
Published: June 2019

Várias são as estratégias de que as línguas lançam mão para a indeterminação do sujeito gramatical nas sentenças. O presente texto busca indicar a influência do parâmetro do sujeito nulo nas possibilidades de emprego dessas estratégias nas línguas pro-drop e naquelas de sujeito obrigatório. Para isso, são apresentadas construções verificadas no português brasileiro (doravante PB), no italiano, no espanhol e no francês. Além disso, havendo interpretações semânticas diferentes para esses sujeitos indeterminados, o que provoca por exemplo a inclusão ou exclusão do falante e/ou do interlocutor nas possíveis referências a que o sujeito pode remeter, é defendida aqui (e talvez expandida) a ideia proposta por Cardinaletti (2004) sobre várias posições possíveis para o sujeito da sentença (tanto sujeito gramatical como da predicação).
Oralidade e escrita na produção de textos narrativos de alunos do ensino fundamental
Authors: Vieira Odília Olinda , Barbosa Marinalva Vieira
Published: June 2019

Neste artigo, analisamos a presença de recursos da oralidade em narrativas escritas de alunos da 6ª série do Ensino Fundamental II e como esses mesmos recursos podem ser mobilizados para facilitar o domínio da produção escrita, através da retextualização e reescrita. A base teórica se fundamenta na concepção de linguagem bakhtiniana, na proposta de interação entre leitura, produção textual e análise linguística de Geraldi (2012,2013), nos estudos de formulação textual da oralidade e escrita de Marcuschi (2003, 2007, 2008, 2010) e na pesquisa de Belintane (2013) sobre a influência da tradição oral no processo de alfabetização e produção textual. Para concretizar este trabalho, foi escolhida uma turma de 6ª série do Ensino Fundamental II de uma escola pública do Município de Uberaba/MG. Basicamente, o método utilizado na produção e seleção dos dados é o indiciário, pois permite ter uma percepção do detalhe linguístico que define a presença da oralidade nas narrativas escritas. A proposta de intervenção visando o ensino da escrita teve duração de um semestre. Na primeira etapa, apresentada e analisada neste artigo, a narrativa oral serviu de base para a construção de um relato escrito. De posse dessa produção, procedemos à análise, definindo os indícios de oralidade nas narrativas escritas e o planejamento de uma sequência de atividades pedagógicas, composta de um estudo comparativo das duas modalidades, retextualização de um texto oral, reescrita de pequenos trechos de textos da turma, estudo de alguns casos de pontuação e ortografia, concluindo-a com a reescrita do primeiro texto pelo próprio aluno.
Impropriedades lexicais em textos de estudantes universitários
Authors: Gil Beatriz Daruj
Published: June 2019

Professores universitários estão insatisfeitos com o desempenho linguístico-acadêmico de seus alunos. Os estudantes alegam que não sabem escrever, que são mal avaliados em suas produções e, finalmente, que desconhecem a saída para o problema. Em estudos a respeito do letramento (BARTON, 2000; GEE, 2004; LEA  e STREET, 2014; STREET, 2003), afirma-se que todos, ao ingressarem na universidade, já possuem conhecimento advindo de vários letramentos anteriores e que, no contexto universitário, precisariam apenas conhecer a norma dos gêneros acadêmicos. A despeito do desconhecimento das convenções do gênero acadêmico, defende-se, neste artigo, que alunos universitários também desconhecem tópicos sobre o funcionamento linguístico-discursivo da língua, o que seria uma razão importante para seu baixo desempenho linguístico. Em função dessa hipótese, analisa-se um conjunto de produções escritas de alunos universitários com o objetivo de identificar impropriedades lexicais que podem contribuir para a avaliação negativa dos textos por eles produzidos.
Análise da utilização das tecnologias digitais por diretores escolares e professores
Authors: Piedade João , Pedro Neuza
Published: June 2019

O presente artigo apresenta os resultados de um estudo desenvolvido em torno da utilização das tecnologias digitais em contexto escolar, em particular, por parte de diretores escolares e professores do ensino básico e secundário Português. Procurou-se, deste modo, analisar os índices de utilização das tecnologias digitais e os níveis de proficiência na utilização das mesmas apresentados pelos diretores e pelos professores nas suas práticas. Organizado com base numa abordagem metodológica de cariz quantitativo, e assumindo uma natureza descritiva e exploratória, o estudo envolveu a recolha de dados junto de 133 diretores escolares e 1908 professores através da aplicação de três escalas self-report. Os resultados reportaram que os diretores escolares apresentam índices médios favoráveis de autoeficácia e de utilização das tecnologias nas suas práticas profissionais. Evidenciaram, igualmente, níveis elevados de utilização das tecnologias por parte dos professores. A análise, cruzando os resultados dos diretores com os dos professores, permitiu agrupar as escolas com base em diferentes patamares considerando o nível de proficiência evidenciada pelos seus diretores e detetar que, no seio destas, a utilização das tecnologias evidenciada pelos seus professores se revela semelhante ao nível de proficiência revelado pelo respetivo diretor.
O (não) lugar do aposentado na instituição:
Authors: Sobral Maria Neide , Francisco Deise Juliana
Published: June 2019

Esse texto apresenta uma análise sobre o processo de preparação, aposentadoria e pós-aposentadoria de docentes universitários do Departamento de Educação da Universidade Federal de Sergipe. O professor universitário vive sua carreira profissional aprisionado em um tempo. Ao final dessa trajetória, esse tempo dedicado ao trabalho precisa ser redimensionado, ressignificado e revisto em outra perspectiva, bem diferente das exigências da vida acadêmica. Um tempo que era da instituição, ocupando muitas horas de seu dia, passa a ser agora só seu, voltando-se para a saúde e o envelhecimento. Trata-se de uma investigação de natureza exploratória, pautada em suporte teórico-metodológico da história oral temática, memórias com levantamento de dados autobiográficos sobre o final de carreira dos docentes Evidencia-se que o “lugar vazio” deixado pelo docente universitário na instituição onde passou boa parte de sua vida é ocupado, quando ele passa a ser inativo, pelo novo lugar na instituição que é o de “arquivo”.
Campanha de Pé no Chão Também se Aprende a Ler:
Authors: Aquino Fernanda Mayara Sales de , Pinheiro Rosa Aparecida
Published: June 2019

Este artigo objetiva discutir os espaços socioeducativos da ‘Campanha de Pé no Chão Também se Aprende a ler’ como lugares de formação política e cultural pertencentes a um contexto de Comunidade de Aprendizagem. Para tanto, como procedimentos metodológicos, utilizamos narrativas de formadores da Campanha em conjunto com fontes documentais, como o Relatório Cultura Popular e De pé no Chão (1963) e a Proposta para criação do projeto ‘Meios informais de educação’ (1961). Para a leitura das fontes, utilizamos o conceito de Comunidade de Aprendizagem (TORRES, 2003) e de ato educativo como ato político (FREIRE, 1987, 2006). Pelas análises, compreendemos que, na Campanha de Pé no Chão Também se Aprende a Ler, as aprendizagens acontecem, além das salas de aula, ou seja, nos espaços socioeducativos – com a criação das praças de cultura, bibliotecas populares, museus e galeria de arte se coadunam com os princípios de uma Comunidade de Aprendizagem no processo educativo percebido como ato político interligado ao contexto cultural.
Formação humana e social a partir da escola
Authors: De Souza Rita de Cássia
Published: June 2019

Este artigo apresenta uma escola que busca uma formação integral para seus estudantes e que tem um plano de trabalho inovador a começar pelo compromisso de transformação social que teve início com a decisão de construí-la numa região de baixos recursos econômicos da cidade de Mérida, no México. Realizamos uma pesquisa qualitativa e descritiva, partindo de um referencial construcionista social, que recomenda que os participantes sejam coautores do trabalho, evitando o distanciamento pesquisador-pesquisado. Neste sentido, convivemos alguns dias dos meses de setembro e outubro de 2018 na escola, participando de aulas e outras atividades e fizemos diálogos gravados com três professores sobre o trabalho da escola. Concluímos que a escola possui um trabalho de formação social e humana que se dá a partir de uma matriz curricular diferenciada, com disciplinas que buscam articular seus conteúdos à realidade dos estudantes, incluindo matérias de formação pessoal, social, profissional e realização de atividades socio comunitárias pelos estudantes.
Editorial
Authors: Araujo Marta Maria
Published: June 2019

Editorial.
O narrador em Corinthians (2) VS. Palestra (1): (im)parcialidade?
Authors: Santos James Rios de Oliveira , Angelo Tiago
Published: June 2019

O presente trabalho objetiva apresentar uma leitura do conto Corinthians (2) VS. Palestra (1), de Alcântara Machado. Texto de grande vigor narrativo, o conto em apreço abre margem para estudos desta natureza dada à linguagem radiofônica mobilizada pelo narrador para a condução dos fatos, uma vez que as marcas linguístico-enunciativas sugerem a torcida do narrador para um dos times de futebol. Pesquisa de natureza bibliográfica, este artigo faz uso do método qualitativo para propor uma leitura que evidencie a imparcialidade do narrador ante o jogo entre Corinthians e Palestra. No curso da análise realizada, constatou-se que o narrador revela-se corintiano, o que o torna uma instância ficcional parcial. Com intuito de atestar tal parcialidade, este estudo mobiliza estudos teóricos e críticos acerca do foco narrativo, tais como o de Norman Friedmann (2002), Wayne Booth (1980) e Davi Arrigucci (1998).
Immunoenhancement of Recombinant Neisseria meningitides PorB Protein on Porcine Circovirus Type 2 and Mycoplasma hyopneumoniae Genetically Engineered Vaccines
Authors: Yang Rui , Tao Yu , Li Gaojian , Chen Jian , Shu Jianhong , He Yulong
Published: June 2019

Background:

Porcine circovirus and Mycoplasma hyopneumoniae can cause respiratory diseases in pigs, which cause serious economic loss in the worldwide pig industry. Currently, these infections are mainly prevented and controlled by vaccination. The new vaccines on the market are mainly composed of subunits and inactivated vaccines but usually have lower antigenicity than traditional live vaccines. Thus, there is an increasing need to develop new adjuvants that can cause rapid and long-lasting immunity to enhance the antigenic efficacy for vaccines. Studies have shown that meningococcal porin PorB can act as a ligand to combine with Toll-like receptors to activate the production of immunological projections and act as a vaccine immunological adjuvant.

Objective:

In this article, we expressed and purified the recombinant PorB protein and verified its immunogenicity against porcine circovirus type 2 and Mycoplasma hyopneumoniae genetically engineered vaccine.

Methods:

In this article, we used prokaryotic expression to express and purify recombinant PorB protein, four different concentrations of PorB protein, Freund's adjuvant with two genetically engineered vaccines were combined with subcutaneous immunization of mice.

Results:

Our study shows that the appropriate dose of the recombinant protein PorB can enhance the levels of humoral and cellular responses induced by two genetically engineered vaccines in a short period of time in mice. The PorB adjuvant group may cause statistically higher antibody titers for both genetically engineered vaccines compared to Freund's commercial adjuvant (P<0.001).

Conclusion:

The recombinant protein PorB may be a good candidate adjuvant for improving the protective effect of vaccines against porcine circovirus type 2 and Mycoplasma hyopneumoniae, and the protein can be used for future practical applications.
Diabetic Hemodialysis: Vitamin D Supplementation and its Related Signaling Pathways Involved in Insulin and Lipid Metabolism
Authors: Hosseini Elahe S. , Kashani Hamed H. , Nikzad Hossein , Soleimani Alireza , Mirzaei Hamed , Tamadon Mohammd R. , Asemi Zatollah
Published: June 2019

Background:

This study was conducted to determine the effects of vitamin D supplementation on some of the gene expressions related to insulin and lipid metabolism in diabetic hemodialysis (HD) patients.

Methods:

A double-blind, randomized, placebo-controlled clinical trial was carried out in 55 patients with diabetic HD. The current project used two groups in which each subject received vitamin D supplements (50,000 IU, n=28) or placebo (50,000 IU, n=27) every 2 weeks for 12 weeks. Gene expression analyses (RT-PCR) were included to obtain the rate of gene expression of the related insulin and lipid metabolism genes in peripheral blood mononuclear cells (PBMCs) of patients with diabetic HD.

Results:

Our data revealed that consumption of vitamin D supplementation enables to overexpress the peroxisome proliferation-activated receptor gamma (PPAR-γ) (P=0.001), AKT (P=0.04), PI3K (P=0.02), insulin receptor substrate-1 (IRS1) (P0.008) and glucose transporter type 4 (GLUT-4) (P=0.01) and downregulate the expression of protein kinase C (PKC) (P=0.001) in patients with diabetic HD than control group following the 12-week intervention. In addition, vitamin D supplementation downregulated low-density lipoprotein receptor (LDLR) (P=0.03) expression in the subjects with diabetic HD than the control group. Vitamin D supplementation did not show any effects on the expression of pyruvate dehydrogenase kinase 1 (PDK1) (P=0.37), IRS2 (P=0.90) and lipoprotein (a) [Lp(a)] (P=0.05).

Conclusions:

Our findings confirmed that diabetic HD subjects who received the vitamin D supplementation (for 12 weeks), showed a significant overexpression in the PPAR-γ, AKT, PI3K, IRS1 and GLUT4 genes, and also showed a significant downregulation in the PKC and LDLR genes. Moreover, no effects on PDK1, IRS2 and Lp(a) expression were observed.
In Vitro and In Silico Studies of Glycyrrhetinic Acid Derivatives as Anti- Filarial Agents
Authors: Tyagi Rekha , Verma Surjeet , Mishra Shikha , Srivastava Mrigank , Alam Sarfaraz , Khan Feroz , Srivastava Santosh Kumar
Published: June 2019

Background:

Lymphatic filariasis is one of the chronic diseases in many parts of the tropics
and sub-tropics of the world despite the use of standard drugs diethylcarbamazine and ivermectin because
they kill microfilaries and not the adult parasites. Therefore, new leads with activity on adult parasites are
highly desirable.

Objective:

Anti-filarial lead optimization by semi-synthetic modification of glycyrrhetinic acid (GA).

Methods:

The GA was first converted into 3-O-acyl derivative, which was further converted into 12 amide
derivatives. All these derivatives were assessed for their antifilarial potential by parasite motility assay.
The binding affinity of active GA derivatives on trehalose-6-phosphate phosphatase (Bm-TPP) was
assessed by molecular docking studies.

Results:

Among 15 GA derivatives, GAD-2, GAD-3, and GAD-4 were found more potent than the GA
and standard drug DEC. These derivatives reduced the motility of Brugia malayi adult worms by up to
74% while the GA and DEC reduced only up to 49%. Further, GA and most of its derivatives exhibited
two times more reduction in MTT assay when compared to the standard drug DEC. These derivatives
also showed 100% reduction of microfilariae and good interactions with Bm-TPP protein.

Conclusion:

The present study suggests that 3-O-acyl and linear chain amide derivatives of glycyrrhetinic
acid may be potent leads against B. malayi microfilariae and adult worms. These results might be
helpful in developing QSAR model for optimizing a new class of antifilarial lead from a very common,
inexpensive, and non toxic natural product.
Diversity-Oriented Synthetic Approaches for Furoindoline: A Review
Authors: Kaur Ramandeep , Kapoor Yagyesh , Manjal Sundeep K. , Rawal Ravindra K. , Kumar Kapil
Published: June 2019

The furo [2,3-b] indoline ring system is one of the most important structural units in various natural
products. It has been known to have inherent biological activities and is utilized as a synthetic target for a
number of natural compounds; therefore, this has contributed to a great demand for the growth of synthetic
methods for this ring system. Most important compounds with furoindoline ring system are physovenine, madindoline
A and B and makomotindoline etc. These compounds are well known to exhibit biological activity
against different diseases such as glaucoma, cancer, cachexia, Castleman’s disease, rheumatoid arthritis, etc.
The current article focuses on various synthetic approaches for furoindoline containing compounds and essential
furoindoline moiety, such as oxindole-5-O-tetrahydropyranyl ether route etc., and various other diastereoand
enantio- controlled approach in a very concise way.
Improvement in Diabetic Control Belief in Relation to Locus of Control
Authors: Haskas Yusran , Suryanto Yusran , Suarnianti Yusran
Published: June 2019

Background:

Adherence to diabetes control is important to determine an individual’s ability to maintain treatment focus of Diabetes Mellitus . The Locus of Control thereby assesses the behavior of an individual to diabetes control.

Objective:

The aim of this study was to analyze the pathways of diabetes control beliefs based on the variable locus of control in the integration of locus of control theory and the theory of planning behavior on diabetes mellitus control behavior.

Methods:

This study was carried out as an explanatory research with a cross-sectional design. The sampling technique was consecutive. The sample size was determined using multivariate numerical analytic one-time predictive concept framework and 143 respondents at 8 locations were recruited by a random lottery method. Demographic data analysis of respondents was done using statistical software, namely IBM Statistics SPSS using a Chi-square statistical test. The proposed hypothesis was tested by the bivariate analysis of variance to assess the effect of causal variables.

Results:

The results of this study indicate that locus of control affects diabetic control beliefs (ρ = 0.05; α = 0.06; b = 0.16; b2 = 0.03; F = 3.91) in the diabetes mellitus control behavior.

Conclusion:

The findings of this study suggest a need to consistently provide positive information and support as a locus of control to guard a strong intention to control diabetes mellitus.
The Emergency Assessment and Management of Non-Suicidal Self-Injury in Adolescents
Authors: Idicula Sindhu A. , Vyas Amy , Garber Nicole
Published: June 2019

Background and Goals:

Non-suicidal self-injury (NSSI) is a common presenting
issue mental health providers experience in all levels of care from outpatient clinics to inpatient
units. It is common among adolescents seen in emergency settings, either as a presenting
problem or as a covert condition that may not be detected unless specifically assessed
for. The presence of NSSI increases the risk of suicide. This article aims to help the clinician
develop a better understanding of NSSI – what it may entail, the prevalence, and the motivations
for why young people engage in it.

Methods:

We review the reasons adolescents injure themselves, the link between NSSI and
psychiatric diagnoses and suicide, the assessment of NSSI, and treatment planning, with emphasis
on ways to screen for NSSI and interventions that can be implemented in the Emergency
Department. We illustrate the complexity of NSSI with the case of a young patient
with a complex psychiatric history and an extensive history of self-injury.

Results and Discussion:

Despite the seeming intractability of NSSI, a number of evidencebased
treatments exist. Treatment primarily involves specialized forms of psychotherapy, but
interventions can be implemented in the ED that will reduce the immediate risk of NSSI
while more definitive intervention is awaited.

Conclusion:

Mental health consultations in the ED should always include screening for
NSSI. Mental health professionals in the ED can play an important role in the detection and
treatment of this condition.
Non-Conventional Desulfurization of Fuels and Biofuels: A Review
Authors: Ghosal Debarpita , Pal Sankhajit
Published: June 2019

Sulphur compounds in fuel cause major environmental pollution. Hence, the desulphurization of fuel has become a tremendous concern. Aside from the standard hydrodesulphurization method, many new processes have gained attention. Our present work discusses varied non-conventional desulphurization techniques likeaerobic desulphurization, adsorbent desulphurization, membrane desulphurization, extractive desulphurization, etc. These strategies in conjunction with their pros and cons are mentioned well.
Social Support Patterns of Middle-Aged and Older Adults Within a Physical Activity App: Secondary Mixed Method Analysis
Authors: Lewis Zakkoyya H , Swartz Maria C , Martinez Eloisa , Lyons Elizabeth J
Published: June 2019

Background

Physical activity (PA) is critical for maintaining independence and delaying mobility disability in aging adults. However, 27 to 44% of older adults in the United States are meeting the recommended PA level. Activity trackers are proving to be a promising tool to promote PA adherence through activity tracking and enhanced social interaction features. Although social support has been known to be an influential behavior change technique to promote PA, how middle-aged and older adults use the social interaction feature of mobile apps to provide virtual support to promote PA engagement remains mostly underexplored.

Objective

This study aimed to describe the social support patterns of middle-aged and older adults using a mobile app as part of a behavioral PA intervention.

Methods

Data from 35 participants (mean age 61.66 [SD 6] years) in a 12-week, home-based activity intervention were used for this secondary mixed method analysis. Participants were provided with a Jawbone Up24 activity monitor and an Apple iPad Mini installed with the UP app to facilitate self-monitoring and social interaction. All participants were given an anonymous account and encouraged to interact with other participants using the app. Social support features included comments and likes. Thematic coding was used to identify the type of social support provided within the UP app and characterize the levels of engagement from users. Participants were categorized as superusers or contributors, and passive participants were categorized as lurkers based on the literature.

Results

Over the 12-week intervention, participants provided a total of 3153 likes and 1759 comments. Most participants (n=25) were contributors, with 4 categorized as superusers and 6 categorized as lurkers. Comments were coded as emotional support, informational support, instrumental support, self-talk, and other, with emotional support being the most prevalent type.

Conclusions

Our cohort of middle-aged and older adults was willing to use the social network feature in an activity app to communicate with anonymous peers. Most of our participants were contributors. In addition, the social support provided through the activity app followed social support constructs. In sum, PA apps are a promising tool for delivering virtual social support to enhance PA engagement and have the potential to make a widespread impact on PA promotion.

Trial Registration

ClinicalTrials.gov NCT01869348; https://clinicaltrials.gov/ct2/show/NCT01869348
Preformed Donor-Specific HLA Antibodies in Living and Deceased Donor Transplantation
Authors: Ziemann Malte , Altermann Wolfgang , Angert Katharina , Arns Wolfgang , Bachmann Anette , Bakchoul Tamam , Banas Bernhard , von Borstel Annette , Budde Klemens , Ditt Vanessa , Einecke Gunilla , Eisenberger Ute , Feldkamp Thorsten , Görg Siegfried , Guthoff Martina , Habicht Antje , Hallensleben Michael , Heinemann Falko M. , Hessler Nicole , Hugo Christian , Kaufmann Matthias , Kauke Teresa , Koch Martina , König Inke R. , Kurschat Christine , Lehmann Claudia , Marget Matthias , Mühlfeld Anja , Nitschke Martin , Pego da Silva Luiza , Quick Carmen , Rahmel Axel , Rath Thomas , Reinke Petra , Renders Lutz , Sommer Florian , Spriewald Bernd , Staeck Oliver , Stippel Dirk , Süsal Caner , Thiele Bernhard , Zecher Daniel , Lachmann Nils
Published: June 2019

Background and objectives

The prognostic value of preformed donor-specific HLA antibodies (DSA), which are only detectable by sensitive methods, remains controversial for kidney transplantation.

Design, setting, participants, & measurements

The outcome of 4233 consecutive kidney transplants performed between 2012 and 2015 in 18 German transplant centers was evaluated. Most centers used a stepwise pretransplant antibody screening with bead array tests and differentiation of positive samples by single antigen assays. Using these screening results, DSA against HLA-A, -B, -C, -DRB1 and -DQB1 were determined. Data on clinical outcome and possible covariates were collected retrospectively.

Results

Pretransplant DSA were associated with lower overall graft survival, with a hazard ratio of 2.53 for living donation (95% confidence interval [95% CI], 1.49 to 4.29; P<0.001) and 1.59 for deceased donation (95% CI, 1.21 to 2.11; P=0.001). ABO-incompatible transplantation was associated with worse graft survival (hazard ratio, 2.09; 95% CI, 1.33 to 3.27; P=0.001) independent from DSA. There was no difference between DSA against class 1, class 2, or both. Stratification into DSA <3000 medium fluorescence intensity (MFI) and DSA ≥3000 MFI resulted in overlapping survival curves. Therefore, separate analyses were performed for 3-month and long-term graft survival. Although DSA <3000 MFI tended to be associated with both lower 3-month and long-term transplant survival in deceased donation, DSA ≥3000 MFI were only associated with worse long-term transplant survival in deceased donation. In living donation, only strong DSA were associated with reduced graft survival in the first 3 months, but both weak and strong DSA were associated with reduced long-term graft survival. A higher incidence of antibody-mediated rejection within 6 months was only associated with DSA ≥3000 MFI.

Conclusions

Preformed DSA were associated with an increased risk for graft loss in kidney transplantation, which was greater in living than in deceased donation. Even weak DSA <3000 MFI were associated with worse graft survival. This association was stronger in living than deceased donation.
Why a Health Administration Internship?
Authors: Wilson Asa B. , Nowak Albert P.
Published: June 2019

A healthcare administration internship is discussed as an important factor in academia’s response to criticism that graduates are not well prepared for job challenges. Employers contend that many graduates have limited critical thinking strengths; a cognitive attribute that manifest itself in needed workplace skills.This article summarizes the conceptual framework and organizational features that, over a seven-year period, fostered the establishment of a statewide undergraduate health administration internship program. The internship is embedded in an AUPHA-certified health administration curriculum in a Midwest state university. The internship is discussed as a part of the health administration curriculum and as an experiential bridge from the university’s didactic world to the health service work environment. Enhancing interns’ critical thinking is the internship goal; an outcome pursued through experiential learning in the placement site and augmented with structured input from the university. Internship projects, assignments, project execution, and, preceptor guidance continuously augment the internship’s cycle of experiential learning. As the internship matured, mutual benefits between the program and participating facilities emerged. These returns are discussed under the headings of: a) employment support, b) research collaboration, c) networking opportunities, d) promotional outreach, and e) outcome-assessment research. These returns continuously reinforce value for all internship stakeholders.
Biblioteca Virtual en Salud (BVS) México Enfermería. Un espacio construido por y para la enfermería mexicana
Authors: Matus-Miranda R.
Published: June 2019

A 20 años del establecimiento de la Biblioteca Virtual de Salud (BVS), como modelo, estrategia y plataforma operacional de cooperación técnica de la Organización Panamericana de la Salud (OPS), para la gestión de la información y del conocimiento en salud en la Región de América Latina y el Caribe (AL&C), hoy día, este espacio es una Red de Redes construida colectivamente coordinada por el Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud, el cual es un organismo especializado de la OPS (BIREME/OPS/OMS), con la misión de contribuir en el desarrollo de la salud en los países de AL&C, por medio de la democratización del acceso, publicación y uso de información, conocimiento y evidencia científica.
Replacement of alfalfa with Tithonia diversifolia in lambs fed sugar cane silage-based diets and rice polishing
Authors: Vega Granados Esteban , Sanginés García Leonor , Gómez Gurrola Agapito , Hernández Ballesteros Antonio , Solano Lourdes , Escalera Valente Francisco , Loya-Olguin José Lenin
Published: June 2019

The aim was to evaluate the effect of replacing alfalfa (AA) with Tithonia diversifolia (TD) in sugar cane silage (SCS) based lamb diets, both with or without supplementation with rice polishings (RP), on in vitro digestibility, nitrogen retention and productive performance. The experimental diets (D) contained the following: D1) 68.6 % of SCS and 29.4 % of TD; D2) 63.7 % of SCS and 34.3 % of AA; D3) 46 % of SCS, 22.6 % of TD and 29.4 % of RP; and, D4) 44.1 % of SCS, 24.5 % of AA and 29.4 % of RP. Diets were isoproteinic and isocaloric. The in vitro digestibility of dry matter and organic matter were greater (P<0.05) with D2 compared to D1 and increased (P<0.05) with RP supplementation, with no difference between D3 and D4. Similarly, productive performance was not different (P>0.05) between diets containing TD or AA. Nevertheless, RP improved (P<0.01) dry matter intake, average daily gain and total body gain with both forages. In conclusion, in sugar cane silage based diets, the replacement of alfalfa with Tithonia diversifolia has no effect on DM digestibility, N retention or productive performance. Complementation with rice polishings improves DM digestibility, N retention and productive performance in animals fed forage rich diets such as those utilized in this study.