bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Phishing Tools: A Thorough Comparison of Features and Performance
Authors: Sharma Ishant , Sharma Aman Kumar
Published: May 2023

Abstract: Phishing attacks are a common form of cyber-attacks that can result in data breaches, financial losses, and harm an organization's reputation. The purpose of the study is to evaluate and compare three popular anti-phishing tools' effectiveness in detecting and preventing such attacks. The research method involves conducting a study to identify best performing antiphishing tool. The findings show that some tools have high accuracy; others have a lower false positive rate. Overall, this research paper provides useful information about the effectiveness of anti-phishing tools and can help organizations select the most appropriate tool for their specific needs.
Chronic Kidney Disease Prediction using Machine Learning Algorithms
Authors: J Prasanna Kumar M , G Nethravathi K
Published: May 2023

Abstract: Diabetes and high blood pressure are the primary causes of Chronic Kidney Disease (CKD). A person with CKD has a higher chance of dying young. Doctors face a difficult task in diagnosing the different diseases linked to CKD at an early stage to prevent the disease. Early discovery of CKD empowers sufferers to get the opportunity remedy to decorate the motion of this infection. CKD is among the top 20 causes of death worldwide and affects approximately 10% of the world's adult population. CKD is a disorder that disrupts normal kidney function. The novelty of this study lies in developing a diagnosis system to detect chronic kidney diseases. This study focused on evaluating a dataset collected from 400 patients containing 24 features. The mean and mode statistical analysis methods were used to replace the missing numerical and nominal values. To choose the most important features, Recursive Feature Elimination (RFE) was applied. Three classification algorithms applied in this study were k-nearest neighbors (KNN), Random Forest Classifier (RFC), and Ada Boost Classifier (ABC). All the classification algorithms achieved promising performance. The RFC and ABC Algorithm outperformed all other applied algorithms, reaching an accuracy, precision, recall, and F1-score of 100% for all measures. Therefore, Machine Learning techniques are of great importance in the early detection of CKD. These techniques are supportive of experts and doctors in early diagnosis to avoid developing kidney failure.
A Novel Approach to Protection of Induction Motor by using Arduino
Authors: Titarmare Megha M. , Borikar Om R. , Fukatkar Nidhi S. , Mude Sandeep K. , Halmare Abhay M.
Published: May 2023

Abstract: Now a days, an important goal for the modern industries is to increase the productivity as well as decrease the production loss in order to stay economically competitive. For this purpose, a system for efficient fault management and also for the quick amendment of faults in the production line is necessary. The major roles of the fault detection and the fault diagnosis system for uninterrupted industrial processes is to make an effective indicator which is capable of identifying the fault status of a particular process and then afterwards taking an appropriate action in order to prevent the future failures and unfavourable accidents. Overloading is one of the major faults that occur in an electrical system, mostly within the industrial premises. Overloading, overvoltage, overcurrent causes harm to the electrical installations. These kind of faults are quite general to occur in industries and therefore, a proper protection scheme is needed. The most commonly used machines in any industry are induction motors. The very foremost step is to analyze the main reason behind the occurrence of the burning out of 3ph Induction Motor. There are various causes that can eventually lead to the failure of motor. Hence after multiple researches, it was studied that one of the most common cause of burning of 3ph induction motor inside the industrial premises was due to overloading. The concept of overloading is quite vast. In order to overcome this general problem of burn-out, an industry needs to install a protection scheme for the induction motor. The protection circuitry must contain of the indication at full load including the provision of tripping circuit at the occurrence of overloading.
Comparative Analysis of Structure for Calamity by using Midas Gen, ETABS and STAAD pro
Authors: Jaiswal Abhishek , Singh Sumeet , Saini Naresh , Sharma Nishant , Khandare Prof. Ninad
Published: May 2023

Abstract: During the past few years the earthquakes have dealt a lot of damage to life and property in India. To overcome this, the need for advancement in construction is necessary. With Scarcity of area and overgrowing population the need of constructing High Rise building has been increasing. Traditional high rise structures are tend to be weak against additional load pressure or earthquakes. To counter such situations and to reduce the effect of such calamity with the help of structural analysis and use of methods like Base Isolation, X bracing and Shear Wall, the intensity of such problem can be reduced to a wide extent. This paper represents the comparison of various methods on normal high rise building with the use of Midas Gen ,ETABS and STAAD pro..We took the case for Seismic zone 2 with medium soil category. Structural engineering software has progressed significantly in recent years. MIDAS GEN, ETABS and STAAD pro conducts structural design and analysis packages that support multiple types of concrete, steel, aluminum and timber international design codes.
A Novel Approach for Identification of Brain Tumour Type in MRI Images using AI Techniques
Authors: Davu Greeshma , Bethapudi Prakash , Davu Ravi
Published: May 2023

Abstract: The main intention of this research is to develop an automated approach that identifies the type of brain Tumour from MRI images of various patients using image processing Techniques. Brain Tumour is a solemn issue that, if not identified at right time and treated in a right way, can lead to impediments, and sometimes require surgery or lead to deaths. Whenever early stage tumours or malignant tumours raise, they can trigger the increase in density within the skull. This may be one of the major reasons for brain damage, and sometimes cause life-threatening. Right treatment and right diagnostics at the right time should be carried out to save the lives. One best technique to discover brain Tumours is Magnetic Resonance Imaging (MRI). This helps in using image processing and AI techniques in detecting Brain Tumour type accurately which helps the oncologist to treat the Tumour efficiently. It has the inclination to yield correct results by implementing on various methods and data sets. By using appropriate image processing and AI techniques on CO-LAB, this work is carried out to identify the type of Tumours like Pituitary Tumour, Glioma Tumour, Meningioma Tumour and no Tumour.
Implementation on IoT Based Traffic Management System for Emergency Vehicles
Authors: Raj Mayank , Anand Anubhaw , Raj Priyesh , Singh Shejal , K Ms. Hemalatha
Published: May 2023

Abstract: In many Indian cities along with those in other nations, congestion caused by traffic is a serious issue. Traffic congestion is caused by signal failure, ineffective law enforcement, and poor traffic administration. The economy, the environment, and general quality of life are all negatively impacted by traffic congestion. Therefore, it is imperative that the traffic congestion issue be managed efficiently. The proposed system's goal is to suggest a smart traffic control and management system that makes use of the Internet of Things, a decentralised strategy and algorithms to handle all traffic circumstances more precisely. The shortcomings of the existing traffic control systems will be fixed by the proposed system. To reduce traffic congestion, a forecast of upcoming traffic density will be made using an algorithm. The proposed method enables an emergency vehicle to travel directly to its location by turning all red lights on its route into green ones, thereby reducing traffic congestion. The system manages traffic signals and reduces wait times during emergencies. This makes it an endeavour that can save a life.
Corona Virus will Change the World How?
Authors: Karim Mr Irfan , Sultana Ms
Published: May 2023

Abstract: This paper present the aftereffect of crown contamination will change the world. An around the globe, novel sickness that keeps us contained in our homes possibly for a critical long time is beginning at now reorienting our relationship to government, to the outside world, even to one another. Two or three changes these specialists need to find in the coming months or years may feel new or upsetting: Will countries remain shut? Will contact become inaccessible? What will befall bistros? Regardless, emergency minutes in like way present chance: consistently advanced and adaptable utilization of improvement, less polarization, a restored thankfulness for the outside and life's other basic joys. Nobody knows accurately what will come, in any case here is our best injury at a manual for the dim ways that society government, remedial organizations, the economy, our ways of life and more will change
Digitalization of Pesantren: A Perspective From Human Capital
Authors: Yuwanda Tonny , Fadhlan Abdi , Bundo Mayang
Published: May 2023

Digital transformation is urgent for every aspect of life today. This is also inseparable from pesantren as Indonesia's centers of Islamic religious education. This study aims to see how the digital transformation process in the human resources field in Islamic boarding schools is. The approach to this research is library research, in which a review of the literature related to the research topic is carried out. The discussion results show that several aspects must be improved, namely 1. Digitizing Human Resource Management Activities, 2. Creative Thinking, Innovative and Collaboration Behavior, 3. Leadership and Digital Transformation, 4. Digital Environment. Transformation in human capital can increase work effectiveness, simplify work and save costs in a sustainable process.
Práticas educativas com as tecnologias digitais
Authors: Pesce Marly Krüger de , Da Cruz Fábia Ramos , Garcia Berenice Rocha Zabott
Published: May 2023

Este trabalho objetiva analisar as práticas pedagógicas de professoras alfabetizadoras que utilizam tecnologias digitais, entendendo que o processo de alfabetização se relaciona ao uso social da língua e que a escola também precisa debruçar-se sobre o ensino do letramento digital. A pesquisa foi um estudo de caso de caráter etnográfico, com observação da escola e de aulas em duas turmas de ensino fundamental I. Os dados foram produzidos a partir do registro de observações das aulas e da entrevista com três professoras. A metodologia de análise foi a de conteúdo, que se propõe a descrever e interpretar os dados. Os resultados apontam que as professoras têm formação em serviço para o uso das tecnologias, promovida pelo gestor e por trocas entre colegas, sendo que suas práticas são focadas na fixação dos conteúdos da alfabetização. As crianças têm facilidade em lidar com algumas ferramentas tecnológicas, mas precisam aprender a utilizá-las como instrumento pedagógico.
Ludicidade ao pensar o tempo
Authors: Alcântara Patrícia Costa de , Fernandes Marcela de Melo
Published: May 2023

O texto, em forma de relato de experiência, apresenta os desafios enfrentados nas aulas de história em uma turma multi-idade, no contexto de implantação da BNCC e do retorno às aulas presenciais após o distanciamento social imposto pela Covid-19. A busca por estratégias pedagógicas adequadas à conjuntura e ao perfil da turma levou a uma aproximação com a ludicidade. A partir da problematização do lugar atribuído ao lúdico na BNCC, argumentamos que experienciar a ludicidade no ensino fundamental – anos finais catalisa a progressão do conhecimento e da abstração conceitual que o documento espera para essa etapa da educação. Conclui-se que ter incluído ludicidade nas aulas de história contribuiu para mobilizar a turma em torno da mesma proposta didática, para a aquisição das habilidades curriculares previstas e para contornar alguns impactos negativos da pandemia.
Escola cívico-militar em Belém/PA
Authors: Costa Tapajós Michelle , Bittencourt da Silva José
Published: May 2023

O presente artigo analisa o processo de institucionalização do Programa Nacional de Escolas Cívico-Militares – Pecim, no Liceu Escola Mestre Raimundo Cardoso, vinculado à Prefeitura Municipal de Belém, Pará, ocorrido em 2020, enfocando interesses de gestores/as locais em transformar uma escola popular em escola cívico-militar – Ecim, sua efetivação e as tensões a partir dessa transformação. Foram realizadas entrevistas semiestruturadas, com professores/as e coordenador/a pedagógico/a, e análise de documentos que embasam o referido programa. Constatou-se que o processo de transformação da maior unidade educativa da rede municipal de educação em Ecim foi antidemocrático, gerando tensões no cotidiano escolar, ocasionadas pelas divergências entre os princípios que embasam as escolas públicas brasileiras e os princípios da caserna, além do fato de que essa transformação teve relação com interesses políticos ligados ao pleito de 2020.
Militarização das escolas públicas no Espírito Santo
Authors: Cardoso Oliose Ivan , Castro de Oliveira Edna
Published: May 2023

Este artigo investiga o processo de militarização de escolas públicas no Espírito Santo – ES, visto que a literatura sobre a implementação das Escolas Cívico-Militares no estado é quase inexistente. Toma-se como fundamento o conceito de rigor em Paulo Freire, para refletir sobre a rigidez alinhada à militarização. Como um estudo exploratório, de caráter qualitativo, lança-se mão da revisão bibliográfica e da análise documental como opção metodológica. São analisadas fontes oriundas do jornal Século Diário, no período de 2019 a 2022, que pautam temas ligados à militarização no ES. Os recortes jornalísticos mostram as tensões e resistências que entidades, representantes políticose coletivos de base têm enfrentado ao agirem contra a rigidez da militarização no estado. Porém, a ação desses movimentos é insuficiente para conter a militarização da sociedade e seus efeitos (aumento de militares na política, perseguições à cultura e educação e mudançasnos modos de punição).
Implicações da militarização na gestão democrática
Authors: Barros Afrânio , Fernandes da Silva Edileuza
Published: May 2023

Discutem-se aqui concepções, práticas de gestão e implicações da militarização na gestão democrática de uma escola pública do Distrito Federal, militarizada no ano de 2019. Foram realizadas entrevistas com uma gestora civil e um gestor militar, que compartilham a denominada ‘gestão cívico-militar’. Com base em pressupostos do materialismo histórico e dialético (MARX, 1982; HÚNGARO, 2001; CURY, 1987), a pesquisa qualitativa, realizada entre 2020 e 2022, caracteriza-se como estudo de caso com emprego da Análise de Conteúdo (BARDIN, 1977). Conclui-se que a militarização nas escolas é um modelo verticalizado de gestão que interfere e enfraquece a gestão democrática e seus princípios previstos na Lei n. 4.751/2012.
“O tempo inteiro sob esse ar de punição”
Authors: Machado Maria Izabel , Rodrigues da Silva Bueno Jéssica
Published: May 2023

O presente artigo aborda tensões na militarização de escolas públicas em Goiás, buscando compreender como os indivíduos concebem estratégias de (re)existência às tentativas de padronização de seus corpos. Como referencial, os conceitos de tecnologias de si, vigilância e punição, em Michel Foucault (1999, 2004, 2005) e Guacira Louro (2022). A pesquisa é qualitativa, com dados obtidos via entrevistas semiestruturadas. Como resultados, a ideia de que os/as sujeitos/as que mais escapam à normalização branca, classe média e heterossexual são os/as que precisam desenvolver mais estratégias de sobrevivência institucional. Para mulheres, negras e homossexuais, a vigilância é acrescida do componente interrelacional, operada por colegas imbuídos/as de senso de dever no cumprimento às normas, por mais contrárias à lógica ou ao sucesso didático pedagógico. Salientamos a coexistência de múltiplas subjetividades entre os polos de adesão integral ao modelo disciplinar e o de ser ‘convidado a se retirar’ por inadaptação.
IDENTIDADES E CRENÇAS SOBRE SER E APRENDER A SER PROFESSOR DE INGLÊS
Authors: Kinoshita Luciana
Published: May 2023

Investigamos as identidades e as crenças de alunos de Letras Inglês da Unifesspa. O objetivo foi compreender como as crenças desses graduandos sobre como ser e aprender a ser professor de inglês estão relacionadas ao processo de formação de suas identidades docentes. A pesquisa bibliográfica foi baseada em estudos da Linguística Aplicada. Desenvolvemos um estudo de caso utilizando narrativas. Resultados apontam que as identidades profissionais dos sujeitos estão sendo construídas a partir das crenças que eles formaram e modificaram ao longo do curso por meio de suas próprias vivências passadas e presentes em ensinar e aprender idiomas em diferentes contextos.
DA TRISTEZA DOS MÓVEIS: AUTORIA FEMININA E REPRESENTAÇÃO DOS OBJETOS EM KÉTALA, DE FATOU DIOME
Authors: Nunes de Souza Rodrigo , Neves Riambau Vanessa
Published: May 2023

A produção literária senegalesa de autoria feminina assume um caráter recente, tendo em vista que as primeiras obras datam de 1970. Destarte, na contemporaneidade, o nome de Fatou Diome figura entre as principais escritoras que aborda, em seus livros, temas como a condição das mulheres, o racismo e questão diaspórica. Contudo, em Kétala, romance de 2006 e traduzido para o português em 2008, a autora traz temas considerados caros para o Senegal: a homossexualidade e a transexualidade, já que, no país, a questão LGBTQIAP+ é criminalizada. Com isso, o seguinte artigo visa problematizar como a autoria feminina senegalesa é vista, a partir da produção literária de Fatou Diome. Além disto, destaca-se, também, como os móveis, objetos e utensílios, responsáveis pela narração da história, são representados e representantes por revelar algumas problemáticas presentes no Senegal, como a já citada questão da autoria feminina, a condição das mulheres e como o romance aborda, de modo ousado, a questão homo/transexual.
LANGSTON HUGHES, LIMA BARRETO E A INALCANÇÁVEL MODERNIDADE
Authors: Chagas Gabriel
Published: May 2023

Este artigo analisa o conto “Poor Little Black Fellow”, do escritor negro norte-americano Langston Hughes (1901 – 1967), em perspectiva comparada aos contos “Teorias do dr. Caruru” e “Agaricus auditae”, do autor negro brasileiro Lima Barreto (1881 – 1922). Com essa leitura, almejo demonstrar como ambos os escritores desconstruíram o princípio hegemônico do que se entendia como “modernidade” no início do século XX. De um lado, Langston Hughes desvelou a falácia racista do “sonho americano” e, de outro, Lima Barreto questionou a eugenia e denunciou o racismo na Primeira República no Brasil. Com base nisso, entrelaço os temas da segregação racial estadunidense e das ideias eugênicas vigentes no Brasil à época para demonstrar como a escrita negra foi capaz de elaborar um contradiscurso da modernidade, fissurando a ideia hegemônica de “progresso” e “civilização”. O argumento central do trabalho é o fato de que a “modernidade”, nas primeiras décadas do século XX, foi uma experiência branca. Sendo assim, a perspectiva teórica desta reflexão pressupõe que o mundo ocidental foi moldado pela lógica da colonialidade, como sugere o argentino Walter Mignolo (2017), e leva em conta, nessas sociedades, a existência de um “contrato racial”, na definição do filósofo jamaicano Charles Mills (1997). Com uma preocupação decolonial, baseia-se também no circuito intelectual caribenho, a partir de Aimé Césaire (1978) e Frantz Fanon (2008), bem como nos estudos sobre o Outro de Gayatri Spivak (2010), Achille Mbembe (2014) e Grada Kilomba (2019).
“SERENDIPIDADES!” E OUTROS FRUTOS ESTRANHOS QUE SE PRODUZEM EM "UM DEFEITO DE COR", DE ANA MARIA GONÇALVES
Authors: Santos Vinícius Ferreira dos , Carbonieri Divanize , Pereira Vinícius Carvalho
Published: May 2023

Neste artigo, realizamos uma análise do romance Um defeito de cor, de Ana Maria Gonçalves, acerca da relação entre as linguagens do prólogo intitulado “Serendipidades!” e a metaficção historiográfica que o sucede. Enquanto o primeiro surge da escrevivência do eu-autoral-personagem criado por Gonçalves, a segunda se vale de uma autoconsciência da textualidade da história, a qual estamos chamando de metaficção historiográfica decolonial, pois emerge da narrativa em primeira pessoa de Kehinde, uma mulher negra escravizada no século XIX. A contiguidade entre essas duas linguagens acaba gerando um “fruto estranho”, que parece demandar uma metodologia hibridizada entre abordagens pós-modernas e decoloniais. uma vez que uma perspectiva que trate a literatura como um campo cristalizado dificilmente dará conta de elucidá-lo. Assim, propomos um método que aborda o literário como uma instância pós-autônoma, questionando o papel da literatura na realidade concreta e examinando a ficcionalidade como uma sombra dessa realidade.
UMA NOTA FILOLÓGICA NA DISPERSÃO ARQUIVÍSTICA DA LIMANA, DE LIMA BARRETO
Authors: Souza Arivaldo Sacramento de
Published: May 2023

Ainda em vida, Lima Barreto enfrentou diversos obstáculos para publicação de obras e, até mesmo, de textos em periódicos mais especializados ou em jornais de ampla circulação. Foi crítico de muitos editores e tipógrafos que o aborreceram muito com erros dos textos por suposta incompreensão de sua letra. Após a sua morte, sua biblioteca foi dispersada e, anos mais tarde, recuperada pelo seu primeiro biógrafo que, juntamente outros intelectuais da palavra, ajudaram a recompor a circulação de Lima Barreto. Neste artigo, discutimos de que maneira a dispersão arquivística de autorias negras tornam as pesquisas de fontes primárias urgentes para construção de argumentos que amplifiquem a fortuna editorial e crítica. Para isso, usamos, como caso paradigmático, os manuscritos preservados na Biblioteca Nacional, seção de Manuscritos, especificamente a Coleção Lima Barreto; a edição do Diário Íntimo do autor; e, por fim, o fac-símile do Inventário também presente na Coleção referida. Com isso, investimos numa leitura filológica que buscou cotejar os manuscritos e o impresso para entender a política editorial definida desde a primeira edição do Diário. Assim, conseguimos compreender que o Diário é uma composição editorial trilhada a partir de índices deixados pelo autor, mas, sobretudo, assumidos pelos editores que investiram na providência de criar uma série textual cronologicamente estabelecida, a fim de dar coerência a papeis que o próprio autor não considerava como dentro de uma cadeia textual.

 

Palavras-chave: Crítica Filológica; Lima Barreto; Diário Íntimo; Crítica Textual; Manuscritos.
A POESIA DE LINO GUEDES E OS DILEMAS DOS HOMENS NEGROS NO PÓS-ABOLIÇÃO
Authors: Riso Ricardo
Published: May 2023

Atuante no movimento social e na imprensa negra paulista da década de 1920 até a sua morte em 1951, o escritor Lino Guedes (1897-1951) buscou retratar na poesia os conflitos e anseios da comunidade negra paulista no pós-abolição, servindo como fonte para refletir as masculinidades negras e os embates entre homens negros e brancos interseccionados por gênero, raça, classe, religião e nacionalidade. Neste artigo, a análise de poemas baseia-se em Oswaldo de Camargo, Zilá Bernd e Cuti, já as masculinidades negras pelas formulações de Osmundo Pinho, Henrique Restier, Rolf de Souza e Frantz Fanon.
DESIGN THINKING NA EDUCAÇÃO
Authors: Gusmão Rogério , Soares Cláudia Vivien Carvalho de Oliveira , Barreto Denise Aparecida Brito
Published: May 2023

O presente artigo contempla os resultados encontrados na ambiência formativa desmembrada pela pesquisa-formação na cibercultura. O objetivo do estudo é aplicar o Design Thinking na perspectiva de criar alternativas inovadoras para problemas cotidianos referentes às tecnologias digitais, apontando possíveis contribuições e deficiências. O corpus é constituído por quatro professores(as) de uma escola pública municipal de Vitória da Conquista, terceira maior cidade do estado da Bahia. Os dados foram produzidos com a articulação dos dispositivos: diário de campo e observação participante, bem como a aplicação das etapas (singulares para este campo empírico) do Design Thinking: reconhecimento, planejamento, empatia, ideação, prototipagem e aplicação. Tendo como ponto de partida o desafio “Como podemos criar uma sala tecnológica atrativa e democrática?”, foi elaborado o Projeto Pequenos Polegares, contemplando necessidades próprias do contexto escolar. Ademais, o estudo aponta que o Design Thinking, tendo como pilares a colaboração, a empatia e a experiência, bem como revelando-se em potência de autoria e criatividade dos(as) professores(as), demonstrou possuir dispositivos formativos em sua essência, visto que os praticantes desde campo empírico tenderam a refletir e modificar as suas posturas frente ao conhecimento, à prática formativa e à própria educação. Por fim, salienta atenção para os processos de inovação que negam a alienação contextual e para os apelos mercadológicos que permeiam as novas propostas apresentadas à educação contemporânea.
Is science possible under occupation? Reflection and coping strategy
Authors: Suchikova Yana , Tsybuliak Natalia , Lopatina Hanna , Popova Anastasiia , Kovachov Sergii , Hurenko Olha , Bogdanov Ihor
Published: May 2023

Science holds the key to the progress and development of any country. The full-scale war of the Russian Federation against Ukraine makes some adjustments to the possibilities of scientific activity. To some extent, it depends on the regional context, since the territory of Ukraine is conditionally divided into three zones: 1) territories that had/have active hostilities; 2) regions that do not have the direct escalation of hostilities; 3) temporarily occupied territories. Our research highlights the impact of the Russian-Ukrainian war on the research activity at the university that has been under temporary occupation. Quantitative and qualitative analysis of the results of the scientists’ survey and included observation allows one to determine the main problems and challenges faced by scientists in occupation conditions. It was determined that in the conditions of occupation, scientists not only lack access to the necessary equipment but are also subject to moral and psychological pressure. However, understanding the meaning and value of one’s scientific achievements for the victory and post-war recovery of Ukraine, the support of the world scientific community inspires creation even in the moment of hardships
A fast UPLC method coupled with PDA-Mass spectrometer (QDa) detectors for simultaneous determination of glycopyrronium bromide, formoterol fumarate dihydrate and their related compounds in pMDI product
Authors: SECKIN SERDAR , ASLAN SERAP SAGLIK
Published: May 2023

Rationale: UPLC method coupled PDA-MS (QDa) detectors was
developed and validated to determine glycopyrronium bromide (GB),
formoterol fumarate dihydrate (FFD) and their corresponding related
substances in pressurised meter dose inhaler (pMDI) products at the
first time. Methods: Chromatographic analyses were achived on
an UPLC system coupled to a single quadrupole mass spectrometer (QDa)
with a PDA detector. C18 column was used preceding the injection valve.
The column temperature was set to 40 ºC, while the autosampler
temperature was set to 5 ºC. 1 µL of sample were injected for each
analysis with a flow rate of 0.1 mL min . Mobile
phase A: 0.5 % formic acid in metanol; Mobile phase B: 0.5 % formic
acid in water. The total run time of the method was 30 min. The PDA
detector was used at 215 nm and the mass detector was used in XIC mode.
Results: Limit of detection (LOD) and limit of quantitation
(LOQ) values of GB impurities were found in the range of 0.28 ng mL
-0.30 ng mL and 0.92 ng mL
-1.01 ng mL , respectively. LOD
and LOQ of FFD impurities were found in the range of 0.13 ng mL
- 0.15 ng mL and 0.47 ng mL
- 0.50 ng mL , respectively. GB
and FFD were found linear and accurate within the range of 900-3600 ng
mL and 500-2000 ng mL
respectively. Calibration range for GB impurities and FFD impurities
1-80 ng mL-1, and 0.5-40 ng mL , respectively.
Accuracy was studied for the related substances within the range of LOQ
value of corresponding impurity and 400 % of the limit value. The
method was linear, rapid, reproducible and accurate.
Conclusion: The proposed method was the fast, linear, accurate
and reproducible. The developed UPLC-MS (QDa) method to determine the
related substances and assay of GB and FFD.
One-dimensional semiconductor-metal heterostructures for solar-to-fuel conversion through water splitting
Authors: Chen Jiayi , Hao Derek , Chen Wei , Liu Yazi , Yin Zongyou , Hsu Hsien-Yi , Ni Bing-Jie , Wang Aixiang , Lewis Simon , Jia Guohua
Published: May 2023

One-dimensional semiconductor-metal heterostructures manifest improved
charge separation capability, tunable band gap and increased surface
area, and have been regarded as promising photocatalysts for
solar-to-fuel conversion through water splitting. We herein review the
synthetic strategies for the rational design and preparation of
one-dimensional semiconductor-metal heterostructures with precise
control in terms of size, shape, composition and function. Approaches
that are capable of improving the photocatalytic performance of
one-dimensional semiconductor-metal heterostructures have been proposed
and analyzed The present work is expected to give the rational design of
one-dimensional semiconductor-metal heterostructures and provide
insights into accomplishing highly efficient photocatalysis based on
such materials
Rice--duck co-culture system promoted phosphorus absorption by changing soil phosphorus forms in the Yangtze River Delta of eastern China
Authors: Sha Zhimin , Gao Hui , Wang Jun , Fang Kaikai , Dai Wei , Cao Linkui
Published: May 2023

Study the variation characteristics of soil phosphorus (P) forms are
crucial for measuring soil quality and P absorption. However, studies on
the effects of rice–duck co-culture system on soil P forms in flooded
and dryer period as well as on the relationships among P forms, P
absorption and environmental factors remain insufficient. A rice field
experiment with consistent P inputs in each fertilizer treatment: no
fertilizer (RD and RM), chemical fertilizer (RDF and RMF), organic
fertilizer (RDO and RMO), and a mixture of 70% chemical and 30%
organic fertilizers (RDFO and RMFO) were conducted to study it. The
results showed that RDO and RDFO had higher readily available inorganic
P pool (Resin P + NaHCO -P ),
extractable organic P fractions (NaHCO -P
+ NaOH-P ), and Fe-P and Al-P (NaOH-P
) than the corresponding rice monoculture. RDF
decreased the extractable organic P fractions (NaHCO -P
+ NaOH-P ) and Fe-P and Al-P (NaOH-P
) compared with RMF; RDO increased the accumulation of
Residual-P while RDF and RDFO decreased the accumulation of Residual-P
compared with RMO, RMF, and RMFO. pH was the dominant factor affecting P
forms of soil. RDF and RDFO had higher P content of grain and straw that
mainly affected by soil NaHCO -P and
NaOH-P than other treatments. Simultaneously,
rice–duck co-culture system can increase phosphorus use efficiency
(PUE), especially RDF significantly increased by 171.63% and 22.63%
than RDO and RDFO, respectively. In conclusion, our results suggested
that rice–duck co-culture can promote rice grain and straw to absorb
soil P by changing the soil pH to stimulate soil surplus P into active
P. RDFO was the most recommended agricultural production model for
comprehensive production.
Robot-assisted laparoscopy does not have demonstrable advantages over conventional laparoscopy in endometriosis surgery: a systematic review and meta-analysis
Authors: Valent Sándor , Csirzó Ádám , Kovács Dénes Péter , Szabó Anett , Fehérvári Péter , Jankó Árpád , Hegyi Péter , Nyirády Péter , Sipos Zoltán , Sára Levente , Acs Nandor , Szabó István
Published: May 2023

Background: Endometriosis is a chronic condition affecting
6-10% of women of reproductive age, with endometriosis-related pain and
infertility being the leading symptoms. Currently, the gold standard
treatment approach to surgery is conventional laparoscopy (CL); however,
the increasing availability of robot-assisted surgery is projected as a
competitor of CL. This study aimed to compare the perioperative outcomes
of robot-assisted laparoscopy (RAL) and CL in endometriosis surgery.
Objectives: We aimed to compare the effectiveness and safety of
these two procedures. Methods: A systematic search was
conducted in three medical databases. Studies investigating different
perioperative outcomes of endometriosis-related surgeries were included.
Results are presented as odds ratios (OR) or mean differences (MD) with
95% confidence intervals (CI). Results: Our search yielded
2,014 records, of which 13 were eligible for data extraction. No
significant differences were detected between the CL and RAL groups in
terms of intraoperative complications (OR=1.07, CI:0.43-2.63),
postoperative complications (OR=1.3, CI:0.73-2.32), number of
conversions to open surgery (OR=1.34, CI:0.76-2.37), length of hospital
stays (MD=0.12, CI:0.33-0.57), blood loss (MD=16.73, CI:4.18-37.63) or
number of rehospitalizations (OR= 0.95, CI:0.13-6.75). In terms of
operative times (MD=28.09 minutes, CI:11.59-44.59) and operating room
times (MD=51.39 minutes, CI:15.07-87.72;), the RAL technique remained
inferior. Conclusions: RAL does not have statistically
demonstrable advantages over CL in terms of perioperative outcomes for
endometriosis-related surgery.
House dust mite SCIT reduces asthma risk and significantly improves long-term rhinitis and asthma control -- a RWE study
Authors: Jutel Marek , Klimek Ludger , Richter Hartmut , Brüggenjürgen Bernd , C Vogelberg
Published: May 2023

Background: The German Therapy Allergen Ordinance (TAO)
triggered an ongoing upheaval in the market for house dust mite (HDM)
allergen immunotherapy (AIT) products. Three HDM subcutaneous AIT (SCIT)
products hold approval in Germany and therefore will be available after
the scheduled completion of the TAO procedure in 2026. In general, data
from clinical trials on the long-term effectiveness of HDM AIT are rare.
We evaluated real-world data (RWD) in a retrospective, observational
cohort study based on a longitudinal claims database including 60% of
all German statutory healthcare prescriptions to show the long-term
effectiveness of one of these products in daily life. Methods:
Subjects between 5 to 70 years receiving their first (index)
prescription of SCIT with a native HDM product (SCIT group) between 2009
and 2013 were included. The exactly 3:1 matched control group received
prescriptions for only symptomatic AR medication (non-AIT group); the
evaluation period for up to 6 years of follow-up ended in February 2017.
Study endpoints were the progression of allergic rhinitis (AR) and
asthma, asthma occurrence and time to the onset of asthma after at least
2 treatment years. Results: 892 subjects (608 adults, 284
children/adolescents) were included in the SCIT group and 2676 subjects
(1824 adults, 852 children/adolescents) in the non-AIT group. During the
follow-up period after at least two years of SCIT, the number of
prescriptions in the SCIT group was reduced by 62.8%
(p<0.0001) for AR medication and by 42.4% for asthma
medication (p=0.0003). New‐onset asthma risk was significantly reduced
in the SCIT vs non‐AIT group by 27.0% (p=0.0212). The asthma preventive
effect of SCIT occurred 15 months after start of the treatment. In the
SCIT group, the time to onset of asthma was reduced compared to the
non-AIT group (p=0.0010). Conclusion: In this RWD analysis
patients aged between 5 to 70 years benefited from SCIT with a native
HDM product in terms of the reduced progression of AR and asthma after
at least 2 years of treatment in the long term. The effects lasted for
up to six years after treatment termination. A significantly reduced
risk of asthma onset was observed, starting after 15 months of
treatment.
A novel electrocardiography algorithm to differentiate between ventricular arrhythmia and right ventricular outflow tract versus left ventricular outflow tract
Authors: Zhang Wei , Huang Kui , Qu Jun , Su Guoying , Li Xinyun , Kong Qingzan , Jiang Hua
Published: May 2023

Aim: To evaluate the accuracy of the diagnostic criteria for
determining the origin of outflow tract ventricular arrhythmia (OTVA)
and develop an electrocardiography (ECG) algorithm to predict its
origin. Method: We analyzed the ECGs of 100 patients with OTVA
who underwent successful ablation. The QRS complex was measured during
sinus rhythm and ventricular arrhythmia (VA). After the ECG algorithm
was developed, it was validated in an additional 100 patients from two
different hospitals. Results: In this retrospective study,
among the parameters without restrictions in the transition lead, the
V2S/V3R index (AUC = 0.89) was significantly better in predicting VA
originating from the right ventricular outflow tract (RVOT). Further,
the larger ISA in V1 and V2 (AUC = 0.90) was significantly better in
predicting VAs originating from the left ventricular outflow tract
(LVOT). Among the parameters with the transition lead in V3, the V2S/V3R
index (AUC = 0.82) was significantly better in predicting VAs
originating from the RVOT. On the other hand, the V3 R-wave deflection
interval (AUC = 0.81) was significantly better in predicting VAs
originating from the LVOT. The algorithm combining the V2S/V3R index and
the larger ISA in V1 and V2 could predict OTVA origin with an accuracy
of 85.00%, a sensitivity of 75.68%, a specificity of 90.48%, a
positive predictive value (PPV) of 82.35%, and a negative predictive
value (NPV) of 86.36%. In the validation study, the algorithm exhibited
excellent accuracy (95.00%) and AUC (AUC = 0.95), with a sensitivity of
94.12%, a specificity of 95.45%, a PPV of 91.43%, and an NPV of
96.92%. Conclusion: Our developed algorithm can reliably
predict OTVA origin without restrictions in the transition lead.
Computational analysis of mechanical behaviour of stem cell in micropipette aspiration technique
Authors: Ghaemi Roza Vaez , Alihemmati Zakieh , Choukan Ehsan , Vahidi Bahman
Published: May 2023

Mechanical properties of living cells play an important role in helping
to understand cell physiology and pathology. However, to ensure
reliability, it is important to precisely define the experimental
conditions of these mechanical test. In this study, viscoelastic
properties of the outer layer (cytoplasm and membrane) were extracted
using standard linear solid model. Finite element modeling of the
two-layer cell was performed and the model was validated by experimental
data. In the two-layer model, the effect of the radius of the nucleus
and the location of the nucleus on the whole cell behavior were
investigated. By increasing nucleus size, the whole cell properties
follow the nucleus properties and the role of the nucleus becomes more
dominant. By dislocating nucleus inside the cytoplasm, the cell behavior
changes significantly and becomes more similar to that of nucleus
properties. Similarly, changing the aspiration pressure and rate,
impacts the observed behavior drastically. The results demonstrate that
the location of the nucleus and the ratio of the radius of the cytoplasm
to the radius of the nucleus can effectively influence the viscoelastic
properties and mechanical behavior of the cell.
The clinical efficacy of biological immunomodulators in SARS-CoV-2- associated multisystem inflammatory syndrome in children: A systematic review
Authors: Ahn Jong Gyun , Lee Ji Young , Kim Jimin , Choi Soo-Han , Kim Dong Hyun , Yun Ki Wook , Kim Yae Jean , Choi Miyoung
Published: May 2023

The clinical efficacy of biological immunomodulators in patients
refractory to standard therapy of intravenous immunoglobulin (IVIg) and
glucocorticoids remains unclear. This review aimed to outline real-world
data on the clinical outcomes of biological immunomodulators using
Ovid-Medline, EMBASE, Cochrane CDSR, and the Korean database, KMBASE
from September 2021 to August 2022. Among 251 studies , 10 were
selected, of which two were observational studies with control groups
receiving a standard therapy of IVIg and/or glucocorticoids. In total,
145 patients were treated with biological agents. In the first study
with a control group, anakinra-treated group exhibited a lower left
ventricular ejection fraction at baseline (54% vs. 60%, P =
0.08). Patients in the infliximab group of second study showed lesser
additional treatment requirements (31% vs. 65%, P = 0.01), and
lower rate of newly developed left ventricular dysfunction (4% vs.
20%, P = 0.05). The remaining eight single-arm studies did not
report the clinical outcomes of each type of biological immunomodulator
individually, limiting further interpretation. The findings of this
review imply the potential of biological immunomodulators as a feasible
therapeutic option for refractory MIS-C.
Using Artificial Intelligence, Machine and Deep Learning to Enhance Evidence-Informed Decision Making
Authors: Munatsi Ronald
Published: May 2023

There is pressure for evidence-informed decision-making (EIDM) emanating
from sustainable development challenges, demand for inclusivity,
transparency and accountability. Machine learning (ML) and Deep Learning
(DL) technologies using Artificial intelligence (AI) can enhance EIDM by
easing complex decision-making processes. There is significant evidence
on the effectiveness of these technologies in processing ‘big data’ too
intricate for conventional processing approaches, but a gap exists in
using them to support EIDM. The review draws from a rapid review of
relevant literature to validate the assertion that ‘ML and DL
technologies using AI can enhance EIDM.’ Findings show that originally
computer applications were more practical at transaction processing
levels and less useful in complex decision support systems. Developments
in AI systems changed this. Data management, analytics and visualisation
agencies now exist, enabling evidence integration by applying erudite
analytics - rendering the evidence easily usable by decision-makers
through intuitive visualisation. Complex decision-making can now be
automated using AI, making it possible to analyse data trends, develop
data consistency, forecast, quantify uncertainty, anticipate user
information needs, provide information in the most appropriate form, and
suggest numerous courses of action. It is now feasible to forecast the
effects of future decisions. This way, policymakers can obtain
transformational insights to improve policy outcomes in critical
sectors.
Can sub-daily multivariate bias correction of regional climate model boundary conditions improve simulation of the diurnal precipitation cycle?
Authors: Kim Youngil , Evans Jason Peter , Sharma Ashish
Published: May 2023

The diurnal cycle is often poorly reproduced in global climate model
(GCM) simulations, particularly in terms of rainfall frequency and
amplitude. While improvements in the regional climate model (RCM) with
bias-corrected boundaries have been reported in previous studies, they
assumed that diurnal patterns are simulated correctly by the GCM,
potentially leading to inaccuracies in the maximum rainfall timing and
magnitude within the RCM domain. Here we provide the first examination
of improvements to the diurnal cycle, within a RCM domain, achieved
through the use of sophisticated bias-corrected lateral and lower
boundary conditions. Results show that the RCMs with bias-corrected
boundaries generally present improvement in capturing both rainfall
timing and magnitude, particularly in northern Australia, where a strong
diurnal pattern in rainfall is prevalent. We show that correcting
systematic sub-daily multivariate bias in RCM boundaries improves the
diurnal rainfall cycle, which is particularly important in regions where
short-term intense precipitation occurs.
Teduglutide therapy in a child with short bowel syndrome
Authors: Stojsic Mirjana , Redzek-Mudrinic Tatjana , Mikov Aleksandra
Published: May 2023

Introduction. Short bowel syndrome (SBS) in children is a rare disease. One of the most common etiological factors for the development of SBS in children is atresia of the small intestine. After surgical correction of the congenital anomaly, the remaining intestine attempts to increase absorption to restore homeostasis, and the process of intestinal adaptation begins. This process of adaptation can be assisted with analogues of endogenous growth factors of the intestine, such as teduglutide. Case outline. This report presents ? girl, aged two years and eight months, who had an estimated 20 cm of small intestine after surgical correction of congenital small bowel atresia and clinical signs of SBS. She was repeatedly hospitalized due to frequent need for parenteral correction of fluid, electrolyte, and nutrient imbalances. Stagnation in body weight and slow growth in body height were accompanied by weakened gross motor strength and slowed psychophysical development. After exploit conservative treatment measures, stimulation of intestinal adaptation was initiated with the drug teduglutide. After six months of drug therapy, progress was observed in body parameters, as well as an increase in intelligence quotient and motor abilities. Conclusion. SBS is a challenging entity for every clinician, and its previous therapy has mainly consisted of parenteral substitution of nutrients, fluids, and electrolytes. Surgical treatment carries the risk of loss of the remaining bowel and lifelong immunosuppression. The pharmacological possibilities of promoting intestinal adaptation using drugs such as teduglutide represent a light at the end of the tunnel for patients with SBS.
Blended learning models dengan pendekatan TPACK berbantuan e-learning: dampaknya terhadap kemampuan pemecahan masalah matematis
Authors: Novilia Reni , Rinaldi Achi , Andriani Siska
Published: May 2023

Kemampuan pemecahan masalah matematis dalam pembelajaran matematika perlu dikuasai siswa guna menunjang proses belajar dan menyelesaikan berbagai permasalahan matematika. Penelitian ini bertujuan untuk mengetahui dampak model pembelajaran Blended Learning dengan pendekatan Technological Pedagogical and Content Knowledge (TPACK) berbantuan E-Learning terhadap kemampuan pemecahan masalah matematis siswa. Penelitian ini merupakan jenis penelitian Quasy Eksperimental Design dengan rancangan penelitian faktorial . Teknik pengumpulan data dalam penelitian ini berupa tes kemampuan pemecahan masalah matematis. Teknik analisis data yang digunakan yaitu uji normalitas, uji homogenitas, dan uji Analisis Variansi Satu Jalur. Berdasarkan hasil penelitian, diperoleh kesimpulan bahwa terdapat dampak penerapan model pembelajaran Blended Learning dengan pendekatan Technological Pedagogical and Content Knowledge (TPACK) berbantuan E-Learning terhadap kemampuan pemecahan masalah matematis siswa. Model pembelajaran Blended Learning dengan pendekatan Technological Pedagogical and Content Knowledge (TPACK) berbantuan E-Learning memberikan dampak yang signifikan terhadap kemampuan pemecahan masalah matematis siswa.
Pendayagunaan Dana Infak dan Sedekah Dalam Program Pilar Ekonomi LAZISNU Kabupaten Tegal
Authors: Hakim Lukmanul , Susanto Dedy , Lestari Widya
Published: May 2023

Program pilar ekonomi diimplementasikan untuk mengatasi kemiskinan dan pengangguran di Kabupaten Tegal. Studi ini mengevaluasi prosedur yang dilakukan oleh LAZISNU dalam mendistribusikan bantuan kepada para pelaku UMKM dan manfaat yang mereka terima. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan studi kasus. Data dikumpulkan melalui wawancara, observasi, dan analisis dokumen. Hasil penelitian menunjukkan bahwa LAZISNU Kabupaten Tegal telah melaksanakan berbagai program pengembangan ekonomi, seperti memberikan modal usaha, pelatihan keterampilan, dan bimbingan usaha, untuk membantu para pelaku UMKM dan masyarakat miskin meningkatkan kesejahteraan dan penghasilan mereka. Program ini membantu mengurangi kesenjangan sosial dan kemiskinan di daerah tersebut. LAZISNU Kabupaten Tegal melibatkan para pelaku UMKM secara langsung dalam menentukan prioritas dan kebutuhan yang tepat.