bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of peri‐operative frailty and operative stress on post‐discharge mortality, readmission and days at home in Medicare beneficiaries
Authors: Park Chan Mi , Lie Jessica J. , Yang Laiji , Cooper Zara , Kim Dae Hyun
Published: May 2024

Background

Understanding how patients' frailty and the physiological stress of surgical procedures affect postoperative outcomes may inform risk stratification of older patients undergoing surgery. The objective of the study was to examine the association of peri‐operative frailty with mortality, 30‐day readmission and days at home after non‐cardiac surgical procedures of different physiological stress.

Methods

This retrospective study used Medicare claims data from a 7.125% random sample of Medicare fee‐for‐service beneficiaries from 2015 to 2019 who were aged ≥ 65 years and underwent non‐cardiac surgical procedure listed in the Operative Stress Score categories. The exposure of the study was claims‐based frailty index (robust, < 0.15; pre‐frail, 0.15 to < 0.25; mildly frail, 0.25 to < 0.35; and moderate‐to‐severely frail, ≥ 0.35) with Operative Stress Score categories being 1, very low stress to 5, very high stress. The primary outcome was all‐cause mortality at 30 days and 365 days after the surgical procedure.

Results

In total, 1,019,938 patients (mean (SD) age of 76.1 (7.3) years; 52.3% female; 16.8% frail) were included. The cumulative incidence of mortality generally increased with Operative Stress Score category, ranging from 5.0% (Operative Stress Score 2) to 24.9% (Operative Stress Score 4) at 365 days. Within each category, increasing frailty was associated with mortality at 30 days (hazard ratio comparing moderate‐to‐severe frailty vs. robust ranged from 1.59–3.91) and at 365 days (hazard ratio 1.30–4.04). The variation in postoperative outcomes by patients' frailty level was much greater than the variation by the operative stress category.

Conclusions

These results emphasise routine frailty screening before major and minor non‐cardiac procedures and the need for greater clinician awareness of postoperative outcomes beyond 30 days in shared decision‐making with older adults with frailty.
Antidote or poison: The relationship between “lying flat” tendency and mental health
Authors: Lu Huanhua , Hou Jun , Wang Jinli , Kong Feng
Published: May 2024

Although “lying flat” has become a new youth subculture phenomenon, it is unclear whether “lying flat” is an antidote or a poison for the youth's mental health. Here, we explored the effect of “lying flat” tendency on mental health using the cross‐sectional (Study 1a) and longitudinal designs (Study 1b) as well as the intervention design (Study 2). In Study 1a, we found that the youth's “lying flat” tendency was negatively correlated with their mental health. Importantly, cross‐lagged analyses (Study 1b) found that “lying flat” tendency negatively predicted mental health 1 month later, suggesting the temporal directionality between “lying flat” tendency and mental health. In Study 2, we sought to examine whether a longitudinal video intervention could promote the youth's mental health by reducing “lying flat” tendency. The results showed that the eight‐day inspirational video intervention significantly reduced the youth's “lying flat” tendency and promoted their mental health. Importantly, “lying flat” tendency mediated the relationship between the inspirational video intervention and mental health. Our study is the first to demonstrate the negatively predictive effect of the “lying flat” tendency on the youth's mental health and provides an economical, convenient, and effective intervention aimed at reducing the “lying flat” tendency to promote the youth's mental health.
Enhanced angiogenesis of human umbilical vein endothelial cells via THP‐1‐derived M2c‐like macrophages and treatment with proteasome inhibitors ‘bortezomib and ixazomib’
Authors: Engür‐Öztürk Selin , Kaya‐Tİlkİ Elif , Cantürk Zerrin , Dİkmen Miriş
Published: May 2024

The leading cause of cancer‐related death is lung cancer, with metastasis being the most common cause of death. To elucidate the role of macrophages in lung cancer and angiogenesis processes, we established an in vitro co‐culture model of A549 or HUVEC with THP‐1 cells that polarized to M2c macrophages with hydrocortisone. The proteasome inhibitors bortezomib and ixazomib were investigated for their effects on proliferation, invasion, migration, metastasis, and angiogenesis pathways. The effects of bortezomib and ixazomib on gene expression in gene panels, including crucial genes related to angiogenesis and proteasomes, were investigated after the co‐culture model to determine these effects at the molecular level. In conclusion, bortezomib and ixazomib showed antiproliferative effects in both cells, as well as in M2c macrophage co‐culture. M2c macrophages also increased invasion in A549 cells and both invasion and migration in HUVEC. mRNA expression upregulation, specifically in the NFKB and VEGF genes, supported the metastatic and angiogenic effects found in A549 and HUVEC with M2c macrophage co‐culture. Additionally, bortezomib inhibited the VEGFB pathway in HUVEC and NFKB1 in A549 cells. The significant findings obtained as a result of this study will provide information regarding angiogenesis induced by M2 macrophages.
Editorial: Infliximab induction therapy in pediatric Crohn's disease—A cost‐effective strategy?
Authors: Chanchlani Neil , Russell Richard K.
Published: May 2024

LINKED CONTENT

This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18000 and https://doi.org/10.1111/apt.18053
Editorial: Infliximab induction therapy in paediatric Crohn's disease — A cost‐effective strategy? Authors' reply
Authors: Vuijk Stephanie A. , de Ridder Lissy
Published: May 2024

LINKED CONTENT

This article is linked to Vuijk et al papers. To view these articles, visit https://doi.org/10.1111/apt.18000 and https://doi.org/10.1111/apt.18033
Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending‐dose study in healthy young men
Authors: Friedrich Christian , Singh Dave , Francke Klaus , Klein Stefan , Hetzel Terence , Zolk Oliver , Gashaw Isabella , Scheerans Christian , Morice Alyn
Published: May 2024

Aims

We report on investigations exploring the P2X3‐receptor antagonist filapixant's effect on taste perception and cough‐reflex sensitivity and describe its pharmacokinetics, including its CYP3A4‐interaction potential.

Methods

In a randomized, placebo‐controlled, double‐blind study, 3 × 12 healthy men (18‐45 years) were assigned (3:1) to filapixant (20, 80 or 250 mg by mouth) or placebo twice daily over 2 weeks. A single dose of midazolam (1 mg), a CYP3A4 substrate, was administered with and without filapixant. Assessments included a taste‐strips test, a taste questionnaire, cough challenge with adenosine triphosphate, adverse event reports and standard safety assessments.

Results

Taste disturbances were observed mainly in the 250‐mg group: six of nine participants (67%) in this group reported hypo‐ or dysgeusia in the questionnaire; eight participants (89%) reported taste‐related adverse events. Five participants (56%) had a decrease in overall taste‐strips‐test scores ≥2 points (point estimate −1.1 points, 90% confidence interval [−3.3; 1.1]). Cough counts increased with adenosine triphosphate concentration but without major differences between treatments. Filapixant exposure increased proportionally to dose. Co‐administration of filapixant had no clinically relevant effect on midazolam pharmacokinetics. Area under the concentration‐time curve ratios and 90% confidence intervals were within 80‐125%. No serious or severe adverse events were reported.

Conclusions

Overall, filapixant was safe and well tolerated, apart from mild, transient taste disturbances. Such disturbances occurred more frequently than expected based on (in vitro) receptor‐selectivity data, suggesting that other factors than P2X3:P2X2/3 selectivity might also play an important role in this context. The cough‐challenge test showed no clear treatment effect. Filapixant has no clinically relevant CYP3A4 interaction potential.
Pleasurable emotions and internalizing psychopathology: A multi‐study examination of specificity and alternative explanations
Authors: Castro Ariana Andrea , DeHart Sam , Berenbaum Howard
Published: May 2024

Objectives

Past research has been inconclusive regarding the specificity of associations between discrete pleasurable emotions and internalizing symptoms. Contentment may be especially relevant to depression, whereas tranquillity may be especially relevant to worry. The goal of the current research was to clarify the mixed findings regarding the relation between pleasure deficits and internalizing psychopathology.

Methods

Participants from three samples (Total N = 757) completed alternative measures of depression and pleasurable emotions. Participants in Study 1 also completed a measure of anticipatory and consummatory pleasure, and close peers to a subset of participants (N = 64) reported their perceptions of participants' depression severity. Participants in Studies 2 and 3 also completed a measure of worry.

Results

Across the three samples, contentment was significantly negatively associated with self‐reported depression. This association could not be accounted for by tranquillity, cheerfulness, anticipatory pleasure, or consummatory pleasure. Contentment was also strongly negatively associated with peer‐reported depression. Contentment was more strongly associated with depression than was cheerfulness. However, the strength of the association between contentment and depression relative to the strength of the association between tranquillity and depression depended on how contentment and depression were measured. Conversely, tranquillity was more strongly associated with worry than were contentment or cheerfulness.

Conclusions

This study provides further evidence of the potential importance of the role of contentment in depression and tranquillity in worry. It may be useful to attend to contentment when assessing and treating depression and to attend to tranquillity when assessing and treating elevated worry.
In‐between group membership within intergroup conflicts: The case of Druze in Israel
Authors: Halabi Slieman , Klar Yechiel , Hanke Katja , Kessler Thomas
Published: May 2024

In‐between groups encompass individuals who simultaneously belong to social categories that are often seen as mutually exclusive in addition to maintaining their distinct group identity. The current paper sheds light on how members of in‐between groups manage their relations within intergroup conflicts. Three studies were conducted among the Druze minority in Israel, a group that is ethnically Arab and shares the Arab identity with the Arab–Palestinian minority in Israel and simultaneously identifies as Israeli. In Study 1 (N = 300), we found that identification as Druze was positively associated with the identification as Arab and Israeli. In Study 2, we examined Druze's endorsement of conflict narratives compared to Jewish‐Israeli and Palestinian citizens (N = 271). While the latter participants endorsed their ingroup narrative more than the outgroup narrative, Druze participants endorsed both narratives equally. In Study 3, we tested Druze's solidarity with the Palestinian minority against the 2018 Nation‐State Law. We found that overall, Druze participants (N = 568) endorsed more inclusive amendments that benefited the Druze and Palestinians than exclusive amendments that benefited the Druze only. In all studies, we tested the role of identification with the rival groups. We discuss these findings and suggest possible underlying mechanisms.
Design, synthesis and neuroprotective biological evaluation of novel HDAC6 inhibitors incorporating benzothiadiazinyl systems as cap groups
Authors: Han Bo , Gu Xiu , Wang Mengfei , Wang Huihao , Sun Niubing , Yang Xuezhi , Zhang Qingwei
Published: May 2024

Histone deacetylase 6 (HDAC6), as the key regulatory enzyme, plays an important role in the development of the nervous system. More and more studies indicate that HDAC6 has become a promising therapeutic target for CNS diseases. Herein we designed and synthesized a series of novel HDAC6 inhibitors with benzothiadiazinyl systems as cap groups and evaluated their activity in vitro and in vivo. Among them, compound 3 exhibited superior selective inhibitory activity against HDAC6 (IC50 = 5.1 nM, about 30‐fold selectivity over HDAC1). The results of docking showed that compound 3 can interact well with the key amino acid residues of HDAC6. Compound 3 showed lower cytotoxicity (20 μM to SH‐SY5Y cells, inhibition rate = 25.75%) and better neuroprotective activity against L‐glutamate‐induced SH‐SY5Y cell injury model in vitro. Meanwhile, compound 3 exhibited weak cardiotoxicity (10 μM hERG inhibition rate = 17.35%) and possess good druggability properties. Especially, compound 3 could significantly reduce cerebral infarction from 49.87% to 32.18%, and similar with butylphthalide in MCAO model, indicating potential clinical application prospects for alleviating ischemic stroke‐induced brain infarction.
Empathy across three generations: From maternal and peer support in adolescence to adult parenting and child outcomes
Authors: Stern Jessica A. , Bailey Natasha A. , Costello Meghan A. , Hellwig Amanda F. , Mitchell Jennifer , Allen Joseph P.
Published: May 2024

This study examined the development of empathic care across three generations in a sample of 184 adolescents in the United States (99 female, 85 male; 58% White, 29% African American, 8% mixed race/ethnicity, 5% other groups), followed from their family of origin at age 13 into their parenting years (through their mid‐30s). Mothers' empathic support toward adolescents at age 13 predicted teens' empathy for close friends across adolescence (13–19 years). Participants' empathic support for friends in late adolescence predicted more supportive parenting behavior in adulthood, which in turn was associated with their children's empathy at age 3–8 years. Results suggest that individuals “pay forward” the empathic care they receive from parents, and that skills developed in adolescent friendships may inform later parenting.
Corporate disclosures need a biodiversity outcome focus and regulatory backing to deliver global conservation goals
Authors: Mair Louise , Elnahass Marwa , Xiang Erwei , Hawkins Frank , Siikamaki Juha , Hillis Laura , Barrie Stephen , McGowan Philip J. K.
Published: May 2024

To achieve the goals of the Kunming–Montreal Global Biodiversity Framework (KMGBF), agreed by Parties to the Convention on Biological Diversity, there is an urgent need to address the economic drivers of biodiversity loss. The KMGBF includes a target to encourage businesses and financial institutions to disclose their impacts and dependences on biodiversity. While transparent biodiversity disclosures could help shift business operations away from activities that harm biodiversity, the weak target wording implies voluntary and unstandardized disclosures, which tend to be low quality and ineffective. Moreover, examination of scientific and practical insights strongly indicates that the evolving strategy of disclosures led by businesses may prioritize short‐term business and investment interests while neglecting biodiversity outcomes and the wider systemic risks they pose. We argue that there is a risk of limited if not altogether perverse outcomes from the target, where businesses provide ambiguous disclosures that fail to reduce impacts on biodiversity, yet an increase in volume and frequency of disclosures suggests progress toward the target. Consequently, we advocate for a regulatory approach, supported by scientific engagement in the development of disclosure standards and associated policy indicators, to ensure that the emerging response to the KMGBF target on disclosures avoids perverse outcomes and instead results in positive impacts on biodiversity.
Micro‐elimination of chronic hepatitis C virus in mental health settings: A prospective multicentre pragmatic trial
Authors: Gofton Cameron , Bondezi Kindness , Kotze Beth , McKee Kristen , Yesudoss Antoni , McCaughan Geoff , George Jacob
Published: May 2024

Introduction

Hepatitis C virus (HCV) prevalence is high in the mental health population. We sought to evaluate testing and treatment uptake for HCV following the implementation of a universal nurse led study in inpatient and outpatient mental health populations.

Methods

From January 2018 to December 2020, we screened mental health inpatients (n = 322) and community mental health patients (n = 615) for HCV with either specialist hepatology nurses or mental health nurses (mental health nurse).

Results

75.5% (464/615) of community patients and 100% (322/322) of inpatients consented to screening, with an HCV antibody‐positive prevalence of 12.7% (59/464) in community patients and 19.6% (63/322) in inpatients. RNA detectable prevalence was 4.0% (22/464) and 7.5% (24/322), respectively. Community patients who were screened by specialist hepatology nurses were more likely to consent to screening (94.4% vs. 45.7%, p < 0.001) but had lower proportion of HCV antibody (10.5% vs. 20.3%, p < 0.001) and RNA detectable (4.0% vs. 7.5%, p = 0.018) when compared to mental health nurse screening. Engagement with treatment was 27.0% of community mental health patients and 45.8% of mental health inpatients undergoing treatment. All patients undergoing treatment and underwent sustained viral response (SVR) testing achieved SVR.

Discussion and Conclusions

Universal screening of HCV using a nurse‐led model has high rates of success in mental health patients with high proportions undergoing screening, with no reduction in the rates of SVR achieved with DAA therapy compared to the general population. Further work is needed to bridge the gap between identification of HCV and treatment among mental health patients.
(Re)envisioning inclusive futures: Applying narrative foresight to deconstruct the problem of urban flooding in the slums of Bengaluru, India
Authors: Nadimpalli SriPallavi , Mathew Sahil , Cheranda Tashina Madappa
Published: May 2024

Motivation

Recurring urban flooding in Bengaluru, India, has brought multiple intersecting development challenges to the forefront. While climate change is a catalyst for flooding, rapid urbanisation has aggravated the problem by neglecting its ecological history. Repeated floods have particularly affected migrants living in the slums, further worsening their already vulnerable conditions. Currently, only about 40% of slums are formally recognized by city authorities, leaving most slum dwellers with limited access to public benefits and basic infrastructure. Although the city offers piecemeal solutions, it currently lacks foresight for long‐term planning that includes marginalized voices.

Purpose

We explore the multiple and intertwined development challenges faced by Bengaluru city, attempting to frame them from the perspective of migrant slum dwellers experiencing flooding. We try to bring to the forefront the everyday risks and vulnerabilities of the marginalized populations in Indian cities, which have received limited attention both in research and policy.

The results of this exercise are intended to create sustainable collaborative processes to inform future decisions, particularly addressing the problem of urban flooding.

Methods and approach

Our proposed methodology integrates climate risk assessment—urban flood modelling and exposure mapping of slums across the city—with vulnerability assessments at the household level including analysis of life histories to capture the relative vulnerabilities of slum dwellers and the slums in which they live.

Findings

We deconstruct urban flooding, particularly from the perspective of migrant slum dwellers to identify some critical challenges, especially that of recognition, to foresight thinking. By incorporating marginalized voices, our methods aim to be inclusive and contextually relevant, while considering intersectional variations among those marginalized.

A mixed‐methods approach allows climate risk assessment to be augmented by life histories of vulnerable slum populations to collaboratively reimagine a more inclusive future.

Policy implications

To make policy more inclusive, more participatory processes are needed. The proposed methods will contextualize everyday vulnerabilities and risks of migrant slum dwellers to bring these perspectives into conventional climate risk assessment. Thus, a more inclusive future with lower impacts from urban floods can be envisaged.
Global prevalence of anemia among women of reproductive age, 2000–2019
Authors: DeLoughery Emma P.
Published: May 2024

A common disease with significant impacts on health and quality of life, anemia is particularly prevalent in women of reproductive age due to blood losses during menstruation and pregnancy. Data from the World Health Organization (WHO) was analyzed to compare trends in prevalence of anemia in women aged 15‐49 among countries and over time with the goal of identifying regions both successful and in need of assistance in combatting anemia.

Worldwide from 2000 to 2013 the prevalence of anemia among women aged 15‐49 decreased, and then increased from 2013 to 2019; severe anemia decreased throughout the world from 2000 to 2019. Throughout all years, African countries had the highest prevalence of anemia and severe anemia while American and European countries had the lowest. With each decrease in human development index (HDI) category (very high to high, etc.) there was a significant increase in prevalence of total anemia (P < 0.001 for all).

This data suggests that although the prevalence of anemia among reproductive age women has decreased over time there is still much work remaining, particularly in low HDI countries. More effort is needed in preventing, recognizing and treating anemia.
The use of parent‐completed questionnaires to investigate developmental outcomes in large populations of children exposed to antiseizure medications in pregnancy
Authors: Bluett‐Duncan Matthew , Bullen Philip , Campbell Ellen , Clayton‐Smith Jill , Craig John , García‐Fiñana Marta , Hughes David M. , Ingham Amy , Irwin Beth , Jackson Cerian , Kelly Teresa , Morrow James , Rushton Sarah , Winterbottom Janine , Wood Amanda G. , Yates Laura M. , Bromley Rebecca L.
Published: May 2024

Objective

This study was undertaken to assess the utility of the Ages and Stages Questionnaire–3rd Edition (ASQ‐3) and the Vineland Adaptive Behavior Scales–2nd Edition (VABS‐II) as neurodevelopmental screening tools for infants exposed to antiseizure medications in utero, and to examine their suitability for use in large‐population signal generation initiatives.

Methods

Participants were women with epilepsy who were recruited from 21 hospitals in England and Northern Ireland during pregnancy between 2014 and 2016. Offspring were assessed at 24 months old using the Bayley Scales of Infant Development–3rd Edition (BSID‐III), the VABS‐II, and the ASQ‐3 (n = 223). The sensitivity and specificity of the ASQ‐3 and VABS‐II to identify developmental delay at 24 months were examined, using the BSID‐III to define cases.

Results

The ASQ‐3 identified 65 children (29.1%) as at risk of developmental delay at 24 months using standard referral criteria. Using a categorical approach and standard referral criteria to identify delay in the ASQ‐3 and BSID‐III at 24 months, the ASQ‐3 showed excellent sensitivity (90.9%) and moderate specificity (74.1%). Utilizing different cut‐points resulted in improved properties and may be preferred in certain contexts. The VABS‐II exhibited the strongest psychometric properties when borderline impairment (>1 SD below the mean) was compared to BSID‐III referral data (sensitivity = 100.0%, specificity = 96.6%).

Significance

Both the ASQ‐3 and VABS‐II have good psychometric properties in a sample of children exposed to antiseizure medications when the purpose is the identification of at‐risk groups. These findings identify the ASQ‐3 as a measure that could be used effectively as part of a tiered surveillance system for teratogenic exposure by identifying a subset of individuals for more detailed investigations. Although the VABS‐II has excellent psychometric properties, it is more labor‐intensive for both the research team and participants and is available in fewer languages than the ASQ‐3.
Fatigue life assessment of carbon nanotubes reinforced Al‐Cu‐Mg composite foams via statistics analysis and computer vision
Authors: Wang Siran , Yin Zhangcheng , Rong Xudong , Song Haipeng , Yang Xudong , Zhao Naiqin
Published: May 2024

The unsatisfactory fatigue performance of Al foams significantly limits their engineering applications. Meanwhile, the unique pore structure of metal foams makes it still challenging to assess its fatigue. Herein, we report an innovative strategy for preparing carbon nanotubes reinforced Al‐Cu‐Mg (CNTs/Al‐Cu‐Mg) composite foams, which exhibit superior compressive strength (16.17 MPa) and fatigue strength (11.17 MPa). Statistics analysis confirms that the fatigue life (Nf) follows Weibull distribution, and P‐S‐N curves were obtained to calculate the theoretical stress level required to achieve the expected Nf. Moreover, computer vision is utilized to monitor the fatigue deformation process and effectively detect fatigue crack initiation sites. Notably, the accuracy of predicted Nf obtained by this method is exceptionally high (98.32%). This work provides a theoretical and practical basis for designing metal foams with superior fatigue properties and offers a promising bottom‐up tactic for predicting the Nf of metal foams to prevent fatigue failure.
Prevention and resolution of headaches occurring during hemodialysis treatment by supplemental oxygen
Authors: Gianneschi Garrett B. , Michaud Jennine M.
Published: May 2024

A patient with end‐stage renal disease experienced severe headaches exclusively during dialysis that were bilateral and throbbing with photophobia, weakness, and lightheadedness. The patient had no history of headaches, and dialysis was determined to be the cause of the severe headaches. More than 10 treatments were attempted without success. Headaches were successfully treated and prevented by addition of 100% oxygen (2 L via nasal cannula) for over 12 months without recurrence at time of publication. This case study indicates that oxygen therapy may be a valuable intervention for headaches during dialysis.
Voluntary counselling and testing points (VCTs) in Poland as a complementary and accessible alternative to public healthcare facilities: A comparative analysis of epidemiological data from the VCTs and the National Institute of Public Health NIH–National Research Institute (2015–2022)
Authors: Szczepański Adrian , Klesiewicz Karolina , Ankiersztejn‐Bartczak Magdalena , Drożdż Kamil , Szetela Bartosz , Olechowska‐Jarząb Aldona , Brzychczy‐Włoch Monika
Published: May 2024

Objective

Voluntary counselling and testing points (VCTs) offer anonymous and free HIV tests in Poland. They also play an essential role in educational initiatives focused on the prevention and diagnosis of HIV and other sexually transmitted infections. However, no comprehensive data is available that summarizes the results of the work carried out by these VCTs. Therefore, our aim was to conduct a comparative analysis of epidemiological data obtained from VCTs and data reported by the epidemiological surveillance undertaken by the National Institute of Public Health NIH–National Research Institute (NIPH NIH–NRI) covering the period from 2015 to 2022.

Methods

This retrospective analysis was conducted on data from 258 071 people attending VCTs in Poland in 2015–2022.

Results

On average, 32 259 individuals underwent testing each year, with a notable increase in the number of people being tested in November. The average positivity rate was 1.39% (3576/258 071). The Masovian voivodeship conducted the most tests and had the highest number of positive results. The comparative analysis of the frequency of detecting positive results in VCTs and those reported in NIPH NIH–NRI data revealed that, on average, 31.49% (3576/11 356) of positive results in Poland between 2015 and 2022 were identified through tests conducted at VCTs.

Conclusion

The positive results identified in VCTs constituted approximately one‐third of all results reported by the National Institute of Public Health NIH–National Research Institute, highlighting the importance of VCTs. Moreover, the high availability of testing in the Masovian voivodeship resulted in better detection of HIV. The educational actions performed during European Testing Week increased the number of tests performed in November.
Preparation of anion‐uptake powder compact containing layered double oxide and metakaolinite
Authors: Machida Shingo
Published: May 2024

A powder compact with anion‐uptake ability was prepared prior to the proceeding of the solid‐state reaction involving layered double hydroxide (LDH) and kaolinite during calcination. LDH features anion‐exchangeable capability, and kaolinite is used as a raw potty material because of the sintering property. In the present study, the solid‐state reaction of LDH with kaolinite did not proceed at 750°C, resulting in the formation of a mixture of layered double oxide (LDO) and metakaolinite. Unlike LDO, which typically undergoes anion‐uptake accompanied by LDH reconstruction, metakaolinite does not revert to kaolinite without the use of hydrothermal conditions. In addition, the powder compact composed of LDO crumbled, whereas the one containing a mixture of LDO and metakaolinite remained intact. When the powder compact of LDO and metakaolinite mixture was immersed in a methyl orange (MO) aqueous solution, an LDH–MO intercalation compound was generated within the compact. By contrast, no such compound was generated when LDO powder was immersed in an MO aqueous solution. These results indicated that the successful preparation of a powder compact with distinct anion‐uptake ability was different from powder, owing to that the solid‐state reaction of LDO with metakaolinite did not proceed at 750°C.
An in situ 3D core–sheath interlayer utilized for reinforcing a WC–Co/3Cr13 brazed joint
Authors: Wang Zeyu , Li Guokun , Yang Mengying , Li Manni , Feng Xinxin , Lei Yucheng
Published: May 2024

Large residual stress induced by significant difference in the coefficient of thermal expansion compromises the mechanical performance of a brazed joint between the WC–Co cemented carbide (YG20) and 3Cr13 stainless steel in a cutting tool of shield machine. In this study, a melamine formaldehyde foam precursor was utilized to produce a 3D hollow carbon foam (HCF) used as interlayer through a high‐temperature carbonization process to aid in the brazing process of YG20 and 3Cr13. First, the morphology and microstructure of the HCF interlayer were revealed as a defect‐rich carbon shell with a hollow structure. Afterward, the effects of introducing the as‐prepared HCF interlayer on the joint microstructure and shear performance were investigated. Results indicate that the HCF interlayer contributed to phase homogenization and, moreover, the residual stress relieving through in situ forming a core (metallic matrix)–sheath (ceramic shell) structure. This method outperformed the direct brazing approach without using an interlayer, with a 41% increase in the joint shear strength due to the synergistic strengthening mechanism of the HCF through residual stress reliving and joint seam toughening. Based on the results, in spite of the residual stress, the fast load transfer and the compensation from the matrix core to the ceramic sheath are responsible for the improved mechanical performance of the joint.
Exploring fracture anisotropy in tantalum carbide compounds: A density functional theory approach
Authors: Hossain Sajjad , Thompson Gregory B. , Weinberger Christopher R.
Published: May 2024

In this paper, we examine the cleavage fracture anisotropy in tantalum carbides, namely, TaC, α‐Ta2C, and ζ‐Ta4C3 − x, using density functional theory (DFT) calculations. Our investigation identifies the presence of multiple low‐energy cleavage planes indicating multiple potential pathways for crack propagation in these ceramics, even the low symmetry compounds. The anisotropy characteristics of cleavage fractures exhibited by α‐Ta2C and ζ‐Ta4C3 − x closely align with the intrinsic fracture anisotropy observed in TaC. Notably, there exist at least three pyramidal planes in ζ‐Ta4C3 − x whose cleavage energies are less than those of the carbon‐depleted basal planes, previously reported to have the lowest cleavage energy. The observed preference in experiments for cleavage along carbon‐depleted basal planes, exclusive of other identified low‐energy planes, points to factors beyond cleavage energy influencing cleavage plane preference.
Artificial intelligence and learning environment: Human considerations
Authors: Jafari Esmaeil
Published: May 2024

Background

Artificial intelligence (AI) has created new opportunities, challenges, and potentials in teaching; however, issues related to the philosophy of using AI technology in learners' learning have not been addressed and have caused some issues and concerns. This issue is due to the research gap in addressing issues related to ethical and human needs, and even values in AI in learning have become more obvious.

Objectives

This study investigates how human‐centered artificial intelligence (HAI) can help learners in a learning environment. In this regard, this article by developing key considerations of HAI in helping students tries to help implement or shift it in the future in learning environments.

Methods

To better understand the key considerations of HAI, qualitative methods and interview techniques were applied in this study. In this regard, 18 samples were interviewed from two groups of experts and faculty members in the fields of technology and computer science and social and humanities sciences. The thematic content analysis method was used to analyse qualitative data.

Results and Conclusions

The results show that AI attempts to integrate ethical and human values in the process of design, development, and research in the fields of recognising and dealing with negative emotions, targeted emotional nature, and access to fairness and justice. It also shows significant promise in understanding feelings and emotions in a learning environment.

Implications

Although AI has been studied in other contexts, HAI has not attracted much attention from researchers. Hence, this study has made worthwhile contributions to the literature as it has specifically focused on HAI in education. In addition, it can resolve some scientific community considerations regarding technological concerns in the field of AI. Furthermore, this article can increase social satisfaction with the use of AI by considering ethical considerations in the learning environment and can particularly benefit researchers, educators, and AI specialists who are involved in the study of HAI applications.
Controlling house fly populations under laboratory conditions: Hydrotaea aenescens larvae as effective predator
Authors: Cavalheiro Caroline da Silva , Morales Diuliani Fonseca , Madeira Bruno , Rodrigues Gratchela Dutra , Ribeiro Paulo Bretanha , Krüger Rodrigo Ferreira
Published: May 2024

Larvae of Hydrotaea are facultative predators of larvae of flies commonly found in poultry farms, chicken and pig waste, and decaying carcasses. One species, the black dump fly, Hydrotaea aenescens (Wiedemann, 1830), coexists with the housefly Musca domestica (Linnaeus, 1758) in these environments and has been employed in the biological control of the housefly in the USA and Germany. To assess the predatory efficacy of H. aenescens larvae on M. domestica larvae, we conducted controlled laboratory experiments in which we selected larvae of different sizes of the larvae and the densities of both predator and prey. We set up the experiment using adult flies from a poultry farm and reared the larvae they produced in our laboratory. Our findings indicate that second‐ and third‐instar H. aenescens larvae effectively suppressed populations of housefly larvae under laboratory conditions, especially when the latter was smaller or the same size as the former. Under these ideal experimental conditions, a single H. aenescens larva consumed up to 29 larvae of M. domestica, potentially leading to a complete eradication of the housefly population at predator–prey density levels of 1:1 and 1:4, but only when considering both the natural mortality rate of M. domestica larvae and the additional mortality caused by H. aenescens larvae. These results corroborate a pattern previously observed in other predatory larvae and have important implications for biological control and integrated pest management programs targeting M. domestica in poultry and swine farms across South America.
A retrospective cohort study of prescription drug use among youth with intellectual/developmental disabilities in British Columbia
Authors: Marquis S. , Marquis N. E. , Lunsky Y. , McGrail K. M. , Baumbusch J.
Published: May 2024

Background

People with intellectual/developmental disabilities (IDD) are known to have high rates of prescription drug use, particularly for psychotropic medications. This is of concern due to the many side effects associated with these medications and because of the risks of polypharmacy. In this paper we compare the most commonly dispensed drugs and all psychotropic medications for youth with IDD compared with youth without IDD.

Methods

Using population‐level administrative health data over a 10‐year period, this study examined medications dispensed to youth with an IDD aged 15–24 years compared with youth without an IDD. The most common medications dispensed and the number of youth they were dispensed to were determined. As well a wide variety of psychotropic medications were examined.

Results

There were a total of 20 591 youth with IDD and 1 293 791 youth without IDD identified. Youth with IDD had higher odds of being dispensed pain medications, amoxicillin, salbutamol, levothyroxine and all the psychotropic medications (antidepressants, antipsychotics, anxiolytics, anti‐adrenergic agents, mood stabilisers and stimulants). For youth with IDD, 6558 (31.85%) were dispensed two or more different psychotropic medications within a year, compared with 75 963 (5.87%) of youth without IDD.

Discussion

Compared to youth without IDD, youth with IDD had significantly higher odds of being dispensed most of the prescription medications studied, including all of the psychotropic medications. They were also twice as likely to be dispensed two or more medications from different classes of psychotropic drugs within the same year. These findings have important implications for the health of people with IDD and for their health care providers.
The Global Transmission of Real Economic Uncertainty
Authors: LONDONO JUAN M. , MA SAI , WILSON BETH ANNE
Published: May 2024

Using a sample of 39 countries representing 88% of global GDP, we find that real economic uncertainty (REU) has negative long‐lasting domestic economic effects and transmits across countries. The international spillover effects of REU are both statistically significant and economically meaningful, and trade ties play a key role in explaining its transmission across countries. Innovations to the foreign component of global REU can contribute up to 16% of the future variation in domestic industrial production. This effect is disproportionately larger on its manufacturing component, which contributes the most to the tradable goods sector, than on its retail sales component.
Moral Constraints, Social Norm Enforcement, and Strategic Default in Weak and Strong Economic Conditions
Authors: BROWN MARTIN , SCHMITZ JAN , ZEHNDER CHRISTIAN
Published: May 2024

We study the behavioral mechanisms which contribute to increased strategic defaults during an economic crisis. In our laboratory experiment, subjects can default on an outstanding loan, but moral constraints and social norm enforcement may provide incentives to repay. We exogenously vary the state of the economy: In the weak economy, more borrowers are forced to default than in the strong. We identify two main effects of weak economic conditions: First, moral constraints are softened: Solvent debtors default more often. Second, under informational uncertainty about the reason for default, social norm enforcement is undermined: Peers are more reluctant to sanction defaulters.
Tumor budding is an optimal indictor of occult cervical metastasis in clinical early‐stage buccal mucosa squamous cell carcinoma
Authors: Zheng Zhi , Yang Huan‐Xing , Fang Yi‐Hong , Wang Jin , Fu Shi‐Wei , Ouyang Qi‐Ming
Published: May 2024

Background

Buccal mucosa squamous cell carcinoma (BMSCC) is an aggressive disease. This study investigated the clinicopathological significance of tumor budding (TB), depth of invasion (DOI), and mode of invasion (MOI) on occult cervical metastasis (CM) of BMSCC.

Methods

Seventy‐one cT1–2N0 BMSCC patients were included in this retrospective study. TB, DOI, MOI, and other clinicopathological features were reviewed. Risk factors for occult CM, locoregional recurrence‐free survival (LRRFS), and overall survival (OS) were analyzed using logistic regression and Cox's proportional hazard models, respectively.

Results

Multivariate analysis with the logistic regression model revealed that MOI, DOI, and TB were significantly associated with occult CM in early‐stage BMSCC after adjusting for variates. However, multivariate analysis with the Cox's proportional hazard model found only TB to be a prognostic factor for LRRFS (hazard ratio 15.03, 95% confidence interval [CI] 1.94–116.66; p = 0.01; trend test p = 0.03). No significant association was found between MOI, DOI, or TB and OS.

Conclusions

The optimal predictor of occult CM and prognosis of early‐stage BMSCC is TB, which may assist clinicians in identifying patients at high risk of cervical metastasis.
Do milk proteins relieve capsaicin‐induced burning sensation in the oral cavity?
Authors: Gøkhan Muhammed Alparslan , Sørensen Esben Skipper , Baad‐Hansen Lene
Published: May 2024

Milk has a soothing effect on the capsaicin‐induced burning sensation in the mouth. This double‐blinded, placebo‐controlled, cross‐over study aimed to investigate if milk proteins could relieve the capsaicin‐induced burning sensation. During each session, the tongue of each participant was exposed to capsaicin twice for 8 min in total. Subsequently, the participants rinsed the mouth with one of three solutions: 5% casein, 5% whey protein, or water. The participants rated the perceived unpleasantness and burning sensation during capsaicin exposure and after rinsing on numerical rating scales. Thermographic imaging and semi‐quantitative sensory testing were performed at baseline, after capsaicin exposure, and after rinsing. No significant differences were observed between sessions in any of the measured parameters (p ≥ .053). Scores for unpleasantness and burning sensation varied over time (p ≤ .006). Heat and mechanical sensitivity changed over time (p < .001). In conclusion, rinsing with milk protein solutions did not have any robust effect in this study design.

Practical Applications

It has been suggested that milk proteins could be responsible for the soothing effect milk has on the capsaicin‐induced burning sensation in the mouth. The present results indicate that milk proteins are not solely responsible for this effect. Shedding light on the effects milk and its constituents have on the oral mucosa during a state of burning sensation or pain is of importance. This can help determining if specific constituents of milk could be used to relieve meal‐related burning sensations as well as illness‐related acute or chronic pain in the oral mucosa.
Nasal high flow therapy for bronchiolitis
Authors: Franklin Donna , Miller Letitia , Pham Trang MT , Frampton Chris , Moloney Susan , Waugh John , Fairless Samantha , Hobbins Sue , Grew Simon , George Shane , Fahy Rose , Morel Douglas , Schibler Andreas
Published: May 2024

Aim

Uptake of nasal high‐flow therapy in infants with bronchiolitis has grown in the last decade with some evidence suggesting a reduction in escalation of care. The effect of the implementation of recent available evidence on clinical practice remains unclear.

Methods

In a prospective observational study over 6 months in six metropolitan hospitals in Australia, we investigated the clinical practice of high‐flow in infants admitted with bronchiolitis and an oxygen requirement. To assess the choice by clinicians of the initial oxygen therapy (standard oxygen or high‐flow) the disease severity was measured by physiological parameters obtained prior to oxygen therapy commencement. Additional secondary outcomes were hospital length of stay and transfers to intensive care.

Results

Two hundred thirty‐five infants with bronchiolitis were admitted for oxygen therapy over 6 months during the winter season. Infants who received high‐flow on admission to hospital displayed significantly higher respiratory rates, higher heart rates and higher early warning tool scores with more severe work of breathing than those commenced on standard oxygen therapy as a first line of oxygen therapy. A significantly longer hospital length of stay of 0.6 days occurred in infants commenced on high‐flow. A significantly greater proportion on high‐flow (23.3%) were admitted to intensive care compared to infants commenced on SOT (10.4%) despite the severity of disease in both groups being similar.

Conclusions

Infants with bronchiolitis presenting with greater disease severity are more likely to receive high‐flow therapy. Escalation of care in an intensive care unit occurred more frequently on infants on high‐flow.

Trial Registration

This trial is registered in the Australian New Zealand Clinical Trial Registry ACTRN12618001206213.
Family based social capital of adults with mild intellectual disabilities supported in 24‐hour residential settings compared to outreach settings
Authors: Giesbers Sanne A. H. , Tournier Tess , Hendriks Alexander H. C. , van Loon Kathleen , Quinet Vicky , Hastings Richard P. , Jahoda Andrew , Embregts Petri J. C. M.
Published: May 2024

To enhance social inclusion of people with (mild) intellectual disabilities, policy tends to focus on increasing their informal supportive networks. Family members, mostly parents, are often the main providers of informal support to people with mild intellectual disabilities. Previous research has shown the utility of social capital as a theoretical framework to examine support in the family relationships of people with mild intellectual disabilities, and has shown that several features of the family‐based social capital of people with mild intellectual disabilities are dependent on support and living arrangements. However, existing research on support and living arrangements does not take the key features of family‐based social capital (i.e., bonding and bridging social capital, reciprocity) into account. Therefore, the aim of the current study is to examine the family‐based social capital of people with mild intellectual disabilities supported in 24‐h residential settings (n = 29) versus outreach support settings (n = 45). All participants were individually interviewed about their family support relationships using the Family Network Method‐Intellectual Disability (FNM‐ID). Data were analyzed quantitatively using social network analyses and group comparisons. No significant differences between the two subgroups were found in the social network measures: the two subgroups did not differ in their experience of bonding and bridging social capital, nor in terms of the experienced reciprocity in their family relationships. However, a few differences in the composition of the family network were found. While people with mild intellectual disabilities in outreach support settings were more likely to include children in their significant family network and to provide support to parents, participants in 24‐h care settings were more likely to report extended family as significant family network members.