bluuebunny/crossref_metadata_2025 huggingface dataset:
Usefulness of Hounsfield Units and the Serum Neutrophil-to-Lymphocyte Ratio as Prognostic Factors in Patients with Breast Cancer
Authors: Hahn Seok , Kim Kwang-Min , Kim Min-Ju , Choi Hyang-Suk , Noh Hany , Cho In-Jeong , Lim Seung-Taek , Lee Jong-In , Han Airi
Published: July 2022

Breast cancer is a leading cause of death worldwide. Tumor vascularity and immune disturbances are hallmarks of cancer. This study aimed to investigate the reciprocal effect of tumor vascularity, assessed by the tumor-to-aorta ratio (TAR) of Hounsfield units (HU) on computed tomography (CT), and host immunity, represented by the serum neutrophil-to-lymphocyte ratio (NLR) from peripheral, complete blood cell counts and its impact on patient survival. Female patients with breast cancer who received primary treatment between 2003 and 2018 at Wonju Severance Hospital, Korea, were included. The final cohort included 740 patients with a mean age of 54.3 ± 11.3 (22–89) years. The TAR was 0.347 ± 0.108 (range, 0.062–1.114) and the NLR was 2.29 ± 1.53 (0.61–10.47). The cut-off value for the TAR and NLR were 0.27 and 1.61, respectively. The patients with a TAR > 0.27 showed a poor recurrence free-interval (RFI) only when their NLR was larger than 1.61, and vice versa. The patients showed worse RFI when they had both high TAR and NLR. Our results suggest a dynamic reciprocal communication between tumor vascularity and systemic immunity.
Prognostic Factors of Pulmonary Metastasectomy for Soft Tissue Sarcomas Arising in the Trunk Wall and Extremities
Authors: Nakayama Shizuhide , Kobayashi Eisuke , Nishio Jun , Toda Yu , Yotsukura Masaya , Watanabe Shun-Ichi , Yamamoto Takuaki , Kawai Akira
Published: July 2022

Although there is no evidence from prospective randomized controlled trials to support this practice, pulmonary metastases of sarcomas are often treated surgically if they are resectable. The purpose of this retrospective study was to evaluate the prognostic factors and outcome of pulmonary metastasectomy (PM) for soft tissue sarcomas (STSs) arising in the trunk wall and extremities in 66 consecutive patients. Prognostic factors associated with disease-specific survival after PM were evaluated using univariate and multivariate analyses. The patients included 38 men and 28 women, with a median age of 49 years. The median disease-specific survival after PM was 48 months, and the 5-year survival rate was 45%. No major perioperative complications occurred. Disease-free interval (<12 months), size of largest lung lesion (≥20 mm), and non-curative resection were independent prognostic factors in multivariate analysis. PM was effective in selected patients with pulmonary metastases from STSs arising in the trunk wall and extremities. Disease-free interval, maximum size of metastases, and resectability were identified as prognostic factors.
Updates in the Use of BCL-2-Family Small Molecule Inhibitors for the Treatment of Relapsed/Refractory Multiple Myeloma
Authors: Parrondo Ricardo D. , Paulus Aneel , Ailawadhi Sikander
Published: July 2022

Despite considerable advances in the treatment of multiple myeloma over the past decade, progression of disease is inevitable, and patients ultimately succumb to relapsed and refractory disease. Efficacious therapeutic regimens that target the key biological pathways that are essential for malignant plasma cell survival are necessary in the efforts to improve patient survival outcomes. The Bcl-2 family of proteins comprise oncogenes that promote myeloma cell survival by conferring resistance to apoptosis. These proteins are frequently upregulated in myeloma cells, thus making them attractive therapeutic targets. Several small molecule inhibitors of Bcl-2-family proteins are currently in clinical development for the treatment of relapsed/refractory multiple myeloma. Venetoclax, a Bcl-2-specific inhibitor, has generated the most clinical data and has shown promising results in patients with multiple myeloma harboring the t (11;14) translocation. Venetoclax has shown efficacy when combined with anti-CD38 monoclonal antibodies, immunomodulatory drugs, and proteasome inhibitors. Several other Bcl-2 inhibitors are in clinical development, as are inhibitors of Mcl-1, a Bcl-2-family oncoprotein that is perhaps more critical for myeloma cell survival than Bcl-2. This review will summarize the latest clinical data regarding the clinical development of Bcl-2-family protein inhibitors in the treatment of relapsed/refractory multiple myeloma.
An Advanced Approach for MgZnAl-LDH Catalysts Synthesis Used in Claisen-Schmidt Condensation
Authors: Zăvoianu Rodica , Mihăilă Silvana-Denisa , Cojocaru Bogdan , Tudorache Mădălina , Pârvulescu Vasile I. , Pavel Octavian Dumitru , Oikonomopoulos Solon , Jacobsen Elisabeth Egholm
Published: July 2022

Using organic-base tetramethylammonium hydroxide (TMAH) is a viable, cheap, and fast option for the synthesis of MgZnAl-LDH-type materials by both co-precipitation and mechano-chemical methods. TMAH presents several advantages, such as the smaller quantity of water required in the washing step compared to the use of inorganic alkalis, the prevention of LDH contamination with alkali cations, and its action as a template molecule in texture tailoring. It also has disadvantages, such as its presence in small quantities in the resulting layered materials. Regardless of the use of organic/inorganic bases and co-precipitation/mechano-chemical methods, zincite stable phase was found in all the synthesized solids. The basicity of catalysts followed the trend: mixed oxides > reconstructed > parent LDH. The memory effect of LDH was supported only by the presence of Mg and Al cations, while Zn remained as a zincite stable phase. The catalytic activities for Claisen-Schmidt condensation of benzaldehyde with cyclohexanone provided values higher than 90% after 2 h, with a total selectivity toward 2,6-dibenzylidenecyclohexanone, while self-condensation of cyclohexanone yielded no more than 7.29% after 5 h. These behaviors depended on catalyst basicity as well as on the planar rigidity of the compound.
Ribosomes and Ribosomal Proteins Promote Plasticity and Stemness Induction in Glioma Cells via Reprogramming
Authors: Hide Takuichiro , Shibahara Ichiyo , Inukai Madoka , Shigeeda Ryota , Kumabe Toshihiro
Published: July 2022

Glioblastoma multiforme (GBM) is a lethal tumor that develops in the adult brain. Despite advances in therapeutic strategies related to surgical resection and chemo-radiotherapy, the overall survival of patients with GBM remains unsatisfactory. Genetic research on mutation, amplification, and deletion in GBM cells is important for understanding the biological aggressiveness, diagnosis, and prognosis of GBM. However, the efficacy of drugs targeting the genetic abnormalities in GBM cells is limited. Investigating special microenvironments that induce chemo-radioresistance in GBM cells is critical to improving the survival and quality of life of patients with GBM. GBM cells acquire and maintain stem-cell-like characteristics via their intrinsic potential and extrinsic factors from their special microenvironments. The acquisition of stem-cell-like phenotypes and aggressiveness may be referred to as a reprogramming of GBM cells. In addition to protein synthesis, deregulation of ribosome biogenesis is linked to several diseases including cancer. Ribosomal proteins possess both tumor-promotive and -suppressive functions as extra-ribosomal functions. Incorporation of ribosomes and overexpression of ribosomal protein S6 reprogram and induce stem-cell-like phenotypes in GBM cells. Herein, we review recent literature and our published data on the acquisition of aggressiveness by GBM and discuss therapeutic options through reprogramming.
A Potential Role of Cyclic Dependent Kinase 1 (CDK1) in Late Stage of Retinal Degeneration
Authors: Zhou Jiaming , Ekström Per
Published: July 2022

Cyclin dependent kinase 1 (CDK1) has long been known to drive the cell cycle and to regulate the division and differentiation of cells. Apart from its role in mitosis regulation, it also exerts multiple functions as a protein kinase, including engagement in cell death, possibly via a cell cycle-independent mechanism. The latter is suggested, since CDK1 re-expression can be found in non-dividing and terminally differentiated neurons in several neurodegeneration models. However, the details of if and how CDK1 might be involved in the neurodegenerative condition, retinitis pigmentosa (RP), which displays progressive vision loss, are unclear. In the present study, we investigated CDK1 in degenerating RP photoreceptors of the rd1 RP model, including whether there is a link between this kinase and the cGMP-PKG system, which is regarded as a disease driver. With experiments performed using either in vivo retinal tissue or in vitro material, via organotypic retinal explants, our results showed that CDK1 appears in the photoreceptors at a late stage of their degeneration, and in such a position, it may be associated with the cGMP-PKG network.
TNF-α Suppresses Apelin Receptor Expression in Mouse Quadriceps Femoris-Derived Cells
Authors: Koyama Tomohisa , Uchida Kentaro , Itakura Makoto , Miyagi Masayuki , Tazawa Ryo , Inoue Gen , Fukushima Kensuke , Ohashi Yoshihisa , Tsukada Ayumi , Takaso Masashi
Published: July 2022

Expression of the apelin receptor, APJ, in skeletal muscle (SM) is known to decrease with age, but the underlying mechanism remains unclear. Increased tumor necrosis factor (TNF)-α levels are observed in SM with age and are associated with muscle atrophy. To investigate the possible interconnection between TNF-α elevation and APJ reduction with aging, we investigated the effect of TNF-α on APJ expression in cells derived from the quadriceps femoris of C57BL/6J mice. Expression of Tnfa and Apj in the quadriceps femoris was compared between 4- (young) and 24-month-old (old) C57BL/6J mice (n = 10 each) using qPCR. Additionally, APJ-positive cells and TNF-α protein were analyzed by flow cytometry and Western blotting, respectively. Further, quadricep-derived cells were exposed to 0 (control) or 25 ng/mL TNF-α, and the effect on Apj expression was examined by qRT-PCR. Apj expression and the ratio of APJ-positive cells among quadricep cells were significantly lower in old compared to young mice. In contrast, levels of Tnfa mRNA and TNF-α protein were significantly elevated in old compared to young mice. Exposing young and old derived quadricep cells to TNF-α for 8 and 24 h caused Apj levels to significantly decrease. TNF-α suppresses APJ expression in muscle cells in vitro. The increase in TNF-α observed in SM with age may induce a decrease in APJ expression.
Crack Behavior of Ni60A Coating Prepared by Laser Cladding on a Tilted Substrate
Authors: Shi Bowen , Mu Xiaokai , Zhan Huan , Deng Linhui , Li Tao , Zhang Hongchao
Published: July 2022

Almost all of the research on cracks in laser cladding is based, at present, on a horizontal substrate, which cannot be directly applied to prepare high performance coatings, especially high hardness coatings, on tilted substrate. In this work, the influence of the substrate’s tilt angle on the crack behavior of high hardness Ni60A coating is studied, based on the laser intensity distribution and energy attenuation models on the tilted substrate. Results show that the cracking rate (the crack number in the unit’s cladding length) of the coating increases with the increasing substrate tilt angle, but the tilt angle has no significant influence on the crack mechanism. The different lap direction has a certain influence on the crack, and the coating prepared by downward lap cladding has a larger cracking rate due to the greater laser energy loss. Furthermore, with the increasing substrate tilt angle, the residual stress increases due to the decreased plastic flow, and the fracture strength decreases due to the decreased dilution rate, which results in the increase in the cracking rate of the Ni60A coating. This work will broaden the application of laser cladding technology on repairing complex parts such as gear and blades.
Corrosion and Degradation of Materials
Authors: Chen Jian , Qiao Yanxin , Meng Fanjiang , Wang Yuxin
Published: July 2022

The corrosion and degradation of materials, i [...]
Research on Narrow Linewidth External Cavity Semiconductor Lasers
Authors: Ding Keke , Ma Yuhang , Wei Long , Li Xuan , Shi Junce , Li Zaijin , Qu Yi , Li Lin , Qiao Zhongliang , Liu Guojun , Zeng Lina
Published: July 2022

Narrow linewidth external cavity semiconductor lasers (NLECSLs) have many important applications, such as spectroscopy, metrology, biomedicine, holography, space laser communication, laser lidar and coherent detection, etc. Due to their high coherence, low phase-frequency noise, high monochromaticity and wide wavelength tuning potential, NLECSLs have attracted much attention for their merits. In this paper, three main device structures for achieving NLECSLs are reviewed and compared in detail, such as free space bulk diffraction grating external cavity structure, waveguide external cavity structure and confocal Fabry–Perot cavity structure of NLECSLs. The Littrow structure and Littman structure of NLECSLs are introduced from the free space bulk diffraction grating external cavity structure of NLECSLs. The fiber Bragg grating external cavity structure and silicon based waveguide external cavity structure of NLECSLs are introduced from the waveguide external cavity structure of NLECSLs. The results show that the confocal Fabry–Perot cavity structure of NLECSLs is a potential way to realize a lower than tens Hz narrow linewidth laser output.
Sharing Economy
Authors: Daglis Theodoros
Published: July 2022

Sharing economy is a new type of economic performance with its main characteristic being the sharing among peers. This can be regarded as a new economical approach with the individuals sharing their remainder resources. In this way, there is less need for the possession of resources leading to a decrease in redundant production. However, many implications arise from this type of economy.
A Numerical Study of the Effect of Vegetative Windbreak on Wind Erosion over Complex Terrain
Authors: Li Hao , Yan Zengfeng , Zhang Zhengmo , Lang Jiachen , Wang Xudong
Published: July 2022

Wind erosion is a typical issue for stone carvings in northwest China caves, and windbreaks such as shelterbelts have proven to be effective in mitigating wind erosion. This study has the main purpose of examining the effect of shelterbelts on alleviating the wind erosion degree of stone carvings. The applicability of the canopy model for reproducing the aerodynamic effects based on the realizable k–ε and LES model was examined by using a validation metric. The shelterbelt structure has been discussed with the goal of finding the optimum canopy structure to provide a guideline for designing shelterbelts. Compared with the LES model, the realizable k–ε model was adopted in this study based on its comprehensive performance. The results show that a canopy with porosity of φ = 30% and a width of 0.3 to 0.5 H has better sheltering efficiency. Compared to the case with no shelterbelt, the wind speed amplification coefficient decreased by 43%, and the significant decrease in the value of the wind speed amplification coefficient in the primary-harm wind direction demonstrates the effectiveness of the shelterbelt. By exploring preventive protection technology in the context of historical stone carving, this study can promote the practice of scientific and technological protection of cultural relics.
Development and Validation of a Single Step GC/MS Method for the Determination of 41 Drugs and Drugs of Abuse in Postmortem Blood
Authors: Orfanidis Amvrosios , Krokos Adamantios , Mastrogianni Orthodoxia , Gika Helen , Raikos Nikolaos , Theodoridis Georgios
Published: July 2022

A toxicology laboratory often receives a high number of samples from cases (autopsies or clinical) that may require the quick delivery of trustworthy, accurate results. Thus, there is a great need for a fast and reliable method that is capable of identifying and determining a large number of drugs and drugs of abuse in biological matrices, and especially in blood. In the present study, we describe the development of a fast and simple gas chromatography–mass spectrometry (GC-MS) method for the determination of 41 drugs and drugs of abuse (DOA) in blood. Sample pre-treatment by alkaline liquid–liquid extraction (LLE) was studied through the utilization of different solvents and solvent-to-sample ratios (v/v), which aimed to achieve a greater extraction efficiency and detection sensitivity with a decreased need for large sample volumes. Butyl acetate with a sample-to-solvent ratio of 4:1 (1 mL blood: 0.25 mL butyl acetate) was the most efficient. The method was validated for all analytes, and the evaluation parameters were within the acceptance criteria. The coefficient of determination (R2) was between 0.9934 and 1, the limits of detection (LODs) ranged between 1 ng/mL and 113 ng/mL, and the limits of quantification (LOQs) were between 4 ng/mL and 375 ng/mL for all analytes. The determinations were accurate (accuracy% from 84% to 114%) and precise (RSD% from 0.66% to 14.8% for low concentrations). Deconvolution Reporting Software (DRS) for GC-MS was optimized and applied for data analysis to enhance the identification potential, thereby avoiding false identifications (false positives) and increased productivity. The NIST Automated Mass Spectral Deconvolution and Identification Software (AMDIS) and the analytical utility Retention Time Lock (RTL) Database Library assisted in data evaluation. The method was applied to 89 postmortem cases (history of mental disorders and use of psychiatric pharmaceuticals) in which diazepam (0.13 to 4.34 μg/mL), citalopram (0.04 to 0.24 μg/mL), alprazolam (0.01 to 0.12 μg/mL), olanzapine (0.009 to 0.083 μg/mL), mirtazapine (0.01 to 0.33 μg/mL), venlafaxine (0.006 to 0.92 μg/mL), haloperidol (0.007 to 0.13 μg/mL), and zolpidem (0.01 to 0.16 μg/mL) were successfully quantitated.
Anticipating Changes in Lifestyles That Shape Travel Behavior in an Autonomous Vehicle Era—A Method-Oriented Systematic Literature Review
Authors: Le Gallic Thomas , Aguilera Anne
Published: July 2022

This article proposes a systematic review of the recent literature on the impacts of the deployment of autonomous vehicles through the lens of lifestyle changes that will modify our mobility practices. It discusses the main findings of the studies, analyzes their links with the foresight methods used by their authors, and identifies research gaps. Four components of lifestyles are considered: residential location, car ownership, activity patterns, and tourism. Particular attention is given to the diversity of the reviewed foresight approaches, to the way they complement one another in the construction of knowledge, and to their influence on the forecasts and the lessons learned. Our work shows a convergence of results across methods, especially for expected impacts on household location and car ownership, and the influence of the way autonomous vehicles are deployed. Our analysis also makes it possible to draw up a more comprehensive and nuanced picture of the anticipated changes in lifestyles, and the main sources of uncertainty. Finally, our work identifies several research gaps and avenues for future studies such as the impacts on job choices and tourism, the need for a better understanding of the links between the different deployment models for autonomous vehicles, and the need to explore more scenarios that are compatible with environmentally- and socially-oriented goals.
Comparison and Optimization of Continuous Flow Reactors for Aerobic Granule Sludge Cultivation from the Perspective of Hydrodynamic Behavior
Authors: Jiang Xinye , Li Hongli , Zhao Qingyu , Yang Peng , Zeng Ming , Guo Du , Fu Zhiqiang , Hao Linlin , Wu Nan
Published: July 2022

Improving treatment efficiency and reducing investment and operating costs make aerobic granular sludge technology (AGS) a promising technology for treating aquaculture wastewater. The development of continuous flow reactors (CFRs) has become a new direction in the research of AGS. This study clarifies the granulation effect, hydrodynamic behavior and particle separation of three different CFRs (R1 to R3). The established CFD model was able to explain the hydrodynamic behavior in all three CFRs; in particular, R3 performed the best from the perspective of hydrodynamic behavior due to its abundant turbulence. In addition, the optimal baffle distance and baffle angle of R3 were simulated to be 40 mm and 60°, respectively, due to them providing the best turbulent flow and particle separation effect. However, an overlarge baffle angle could weaken the turbulent pattern in the reactor. The retention time distribution further confirmed the reasonability of these optimal parameters with the highest effective volume ratio of 0.82. In short, this study gives an instruction for exploring the rapid formation mechanism of AGS in a CFR to promote its engineering application.
Effects of a Two-Step Cognitive and Relaxation Training Program in Care Home Residents with Mild Cognitive Impairment
Authors: Stuerz Kristina , Hartmann Sabine , Holzner Bernhard , Bichler Carina S. , Niedermeier Martin , Kopp Martin , Guenther Verena
Published: July 2022

The aim of the present study was to assess the impact of a relaxation training program (RT), a cognitive training program (CT), and the combination of both on changes in cognitive status, emotional status, and experience of pain in older adults with mild cognitive impairment (MCI). Fifty care home residents underwent either RT (26 participants) or CT (24 participants) in the first training period, followed by the combined relaxation and cognitive training program in the second. Psychological tests on cognitive performance, mood disturbance/well-being, depression, and experience of pain were implemented at three time points of measurement, before (t1), after (t2) the first training period, and after the second training period (t3). Both RT and CT with the subsequent combined training program in the second training period, respectively, increased cognitive performance and well-being, and reduced mood disturbance, depression, and the experience of pain. The study showed the non-inferiority of RT in respect of cognitive and emotional status in care home residents with MCI compared to the more frequently implemented CT. Both training programs are high in acceptability and positive outcomes on cognitive, emotional, and pain status support the use of a combination of RT and CT.
Supporting Youth and Families in Gaza: A Randomized Controlled Trial of a Family-Based Intervention Program
Authors: Miller-Graff Laura E. , Cummings E. Mark
Published: July 2022

Background: A total of 450 million children are now living in active conflict zones. The negative consequences for children are significant and long lasting. In response to the urgent need for sustainable interventions for children and families, the current study evaluated a brief (12 hr, 8 session) family-based coping and support program, Promoting Positive Family Futures (PPFF), in Gaza. Methods: Families (n = 68, mother/father/adolescent triads) were randomized into the PPFF intervention or another lengthier (50 hr, 25 session) locally well-established psychosocial support program (treatment as usual; TAU). Results: Improvements were found for both conditions for paternal and maternal depression, emotion regulation using cognitive reappraisal, family-wide emotional security, and adolescent adjustment. Effect sizes were medium to large (d = 0.35–1.27). Fathers in the PPFF condition reported lower depression and higher emotion regulation using cognitive reappraisal at post-test than did fathers in the TAU condition. Mothers in the PPFF condition reported higher levels of emotion regulation using cognitive reappraisal at post-test than did mothers in the TAU condition. PPFF was also indirectly associated with improved depression at post-test for both mothers and fathers via improvements in emotion regulation using cognitive reappraisal and with adolescent adjustment at six months via improvements in maternal emotion regulation using cognitive reappraisal. Conclusions: These findings suggest that the PPFF intervention has many benefits comparable with a longer and locally well-established program. PPFF was also associated with unique positive implications for family-wide adjustment over time. Support was also identified for transdiagnostic processes of improvement associated with the PPPF intervention consistent with the theoretical models informing the approach.
The Roles of Health and e-Health Literacy, Conspiracy Beliefs and Political Sympathy in the Adherence to Preventive Measures Recommended during the Pandemic
Authors: Duplaga Mariusz
Published: July 2022

Adherence to preventive measures is of the utmost importance for limiting the spreading of the coronavirus. Many predictors of adopting preventive behaviors have been analyzed in different countries during the COVID-19 pandemic. Objectives: The study’s main aim was to assess the roles of health (HL) and e-health literacy (eHL), conspiracy beliefs, political sympathy, and religious practices in the adherence to COVID-19 preventive measures after adjusting for sociodemographic factors. The analysis was based on the data obtained from a survey conducted among 2410 adult Internet users in Poland in October 2020. The survey was performed with a computer-assisted web-based interviewing technique. Survey data were analyzed through uni- and multivariable linear regression models. The multivariable regression model revealed that after adjusting for sociodemographic variables, the preventive measures score (PMS) was significantly associated with HL (B = 0.04, p < 0.001), eHL (B = 0.03, p < 0.001) and the COVID-19-related conspiracy beliefs score (C19CBS) (B = −0.24, p < 0.001). There was also a significant statistical relationship between PMS and political sympathies and religious practices. HL and eHL are key factors eligible for modification through appropriate interventions and showing positive effects in compliance with preventive measures. Conspiracy beliefs, political sympathy and religious beliefs are independently associated with the adherence.
COVID-19 Pandemic Impact on Undergraduate Nursing Students: A Cross-Sectional Study
Authors: Curcio Felice , González Cesar , Zicchi Maria , Sole Gabriele , Finco Gabriele , Ez zinabi Oumaima , Melo Pedro , Galletta Maura , Martinez-Riera José
Published: July 2022

COVID-19 is a challenge for education systems around the world. This study aimed to evaluate the perceived impact of the COVID-19 pandemic on nursing students, by assessing their emotions, the level of concern in contracting the virus and their perceived stress. We conducted an observational cross-sectional study. A total of 709 nursing students completed an anonymous questionnaire. The levels of anxiety and stress were assessed using the generalized anxiety disorder scale and the COVID-19 student stress questionnaire, respectively. In total, 56.8% of the sample often or always found it difficult to attend distance-learning activities. The main difficulty referred to was connection problems (75.7%). The mean generalized anxiety disorder score was 9.46 (SD = 5.4) and appeared almost homogeneous among students across the three years of study; most of the students showed mild (35%) to moderate (27%) levels of anxiety; 19% had severe anxiety. The overall COVID-19 stressor mean scores were 11.40 (SD = 6.50); the majority of the students (47.1%) showed scores indicative of moderate stress, 25% showed low stress levels, and 28% showed high-stress levels. Improvements and investments are needed to ensure high-quality distance learning, adequate connectivity, technical support for students, as well as strategies to promote mental health.
Physiological Role of Orexinergic System for Health
Authors: Villano Ines , La Marra Marco , Di Maio Girolamo , Monda Vincenzo , Chieffi Sergio , Guatteo Ezia , Messina Giovanni , Moscatelli Fiorenzo , Monda Marcellino , Messina Antonietta
Published: July 2022

Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding behavior and the sleep and wakefulness states. Since their discovery, several lines of evidence have highlighted that orexin neurons regulate a great range of physiological functions, giving it the definition of a multitasking system. In the present review, we firstly describe the mechanisms underlining the orexin system and their interactions with the central nervous system (CNS). Then, the system’s involvement in goal-directed behaviors, sleep/wakefulness state regulation, feeding behavior and energy homeostasis, reward system, and aging and neurodegenerative diseases are described. Advanced evidence suggests that the orexin system is crucial for regulating many physiological functions and could represent a promising target for therapeutical approaches to obesity, drug addiction, and emotional stress.
The Health Needs of Regionally Based Individuals Who Experience Homelessness: Perspectives of Service Providers
Authors: Bennett-Daly Grace , Maxwell Hazel , Bridgman Heather
Published: July 2022

The bidirectional relationship between homelessness and poor health and the barriers that individuals who experience homelessness face when trying to access healthcare are well documented. There is, however, little Australian research exploring the situation of individuals who experience homelessness in regional contexts and, moreover, from the perspective of service providers. A qualitative descriptive methodology underpinned this study, with in-depth semi-structured interviews being conducted with 11 service providers to identify barriers to care faced by people who experience homelessness and barriers that service providers themselves experience in supporting this population. The key barriers identified were client-level barriers: living day-by-day, financial, health literacy, mental health conditions, behaviour, safety and stigma; provider-level barriers: few bulk-billing doctors, fragmented services, limited resources, negative past experiences with healthcare; and system level barriers: transportation, over-stretched healthcare services. The combined impact of these barriers has significantly contributed to the desperate situation of people experiencing homelessness in Launceston. This situation is likely replicated in other regional populations in Australia. Given that individuals experiencing homelessness have higher rates of every measure in health inequality, steps need to be taken to reduce barriers, and a standardised approach to health care urgently needs to be implemented by governments at the state and national level to improve the health of regionally based individuals experiencing homelessness.
Adverse Effects of Angiotensin-Converting Enzyme Inhibitors in Humans: A Systematic Review and Meta-Analysis of 378 Randomized Controlled Trials
Authors: Na Takuathung Mingkwan , Sakuludomkan Wannachai , Khatsri Rapheephorn , Dukaew Nahathai , Kraivisitkul Napatsorn , Ahmadmusa Balqis , Mahakkanukrauh Chollada , Wangthaweesap Kachathip , Onin Jirakit , Srichai Salin , Buawangpong Nida , Koonrungsesomboon Nut
Published: July 2022

Background: Although angiotensin-converting enzyme (ACE) inhibitors are among the most-prescribed medications in the world, the extent to which they increase the risk of adverse effects remains uncertain. This study aimed to systematically determine the adverse effects of ACE inhibitors versus placebo across a wide range of therapeutic settings. Methods: Systematic searches were conducted on PubMed, Web of Science, and Cochrane Library databases. Randomized controlled trials (RCTs) comparing an ACE inhibitor to a placebo were retrieved. The relative risk (RR) and its 95% confidence interval (95% CI) were utilized as a summary effect measure. A random-effects model was used to calculate pooled-effect estimates. Results: A total of 378 RCTs fulfilled the eligibility criteria, with 257 RCTs included in the meta-analysis. Compared with a placebo, ACE inhibitors were associated with an significantly increased risk of dry cough (RR = 2.66, 95% CI = 2.20 to 3.20, p < 0.001), hypotension (RR = 1.98, 95% CI = 1.66 to 2.35, p < 0.001), dizziness (RR = 1.46, 95% CI = 1.26 to 1.70, p < 0.001), and hyperkalemia (RR = 1.24, 95% CI = 1.01 to 1.52, p = 0.037). The risk difference was quantified to be 0.037, 0.030, 0.017, and 0.009, respectively. Conclusions: We quantified the relative risk of numerous adverse events associated with the use of ACE inhibitors in a variety of demographics. This information can help healthcare providers be fully informed about any potential adverse consequences and make appropriate suggestions for their patients requiring ACE inhibitor therapy.
The Influence of Reducing Clinical Practicum Anxiety on Nursing Professional Employment in Nursing Students with Low Emotional Stability
Authors: Lai Mei-Hsin , Tzeng Chyn-Yuan , Jen Hsiu-Ju , Chung Min-Huey
Published: July 2022

Nursing students experience anxiety during clinical practicum, which may interfere with their learning in clinical practice and nursing employment after graduation. This study explored: (1) the factors of the difference in anxiety levels between pre- and post-practicum in nursing students; (2) identified their anxiety events in a clinical environment; and (3) the correlation between emotional stability and 5-year nursing professional employment. The study was designed as a mixed method. A longitudinal secondary analysis method and a qualitative approach with open questionnaire were conducted. The emotional stability subscale of Lai’s Personality Inventory and the Beck Anxiety Inventory, as well as open questionnaires were administered. Research data were collected through the purposive sampling of 237 nursing students (mean age was 20.96, SD = 1.29) of 4.2% male and 95.8% female in a central Taiwan hospital in 2013, and the participants were followed up in 2021 to show 70% in clinical service. Most of the nursing students exhibited significantly decreased anxiety levels in the post-practicum period. Compared to nursing students with high emotional stability, those with low emotional stability exhibited higher differences in their anxiety levels between the pre- and post-practicum periods. Low emotional stability is critical in a pre-practicum BAI score. However, the high pre-practicum BAI score would decrease to normal range after enrolling to practicum setting. So, as to their 5-year nursing professional employment after graduation. Teachers foster a positive learning atmosphere that emphasizes the importance of “we are family” to students. Teachers and advisors need to make efforts in leading the low emotional stability nursing students to learn effective coping and adapting strategies in clinical practicum.
Employment Industry and Occupational Class in Relation to Serious Psychological Distress in the United States
Authors: Gullett Lauren R. , Alhasan Dana M. , Jackson W. Braxton , Jackson Chandra L.
Published: July 2022

Occupational characteristics may influence serious psychological distress (SPD) and contribute to health inequities; yet, few studies have examined multiple employment industries and occupational classes in a large, racially diverse sample of the United States. Using data from the National Health Interview Survey, we investigated employment industry and occupational class in relation to SPD in the overall population and by race/ethnicity, gender, age, household income, and health status. We created eight employment industry categories: professional/administrative/management, agricultural/manufacturing/construction, retail trade, finance/information/real estate, educational services, health care/social assistance, accommodation/food services, and public administration/arts/other services. We also created three occupational class categories: professional/management, support services, and laborers. SPD was measured using the Kessler Psychological Distress Scale and scores ≥13 indicated SPD. We adjusted for confounders and used Poisson regression to estimate prevalence ratios (PRs) and 95% confidence intervals (CIs). Among the 245,038 participants, the mean age was 41.7 ± 0.1 years, 73% were Non-Hispanic (NH)-White, and 1.5% were categorized as having SPD. Compared to the professional/administrative/management industry, working in other industries (e.g., manufacturing/construction (PR = 0.82 [95% CI: 0.70–0.95]) and educational services (PR = 0.79 [95% CI: 0.66–0.94])) was associated with lower SPD. Working in support services and laborer versus professional/management positions were both associated with 19% higher prevalence of SPD (95% CI: 1.04–1.35; 95% CI: 1.04–1.38, respectively). Furthermore, working in a support services or laborer versus professional/management position was associated with higher SPD in most employment industries. Industry-specific workplace interventions to equitably improve mental health are warranted.
Gestational Diabetes Mellitus: A Cross-Sectional Survey of Its Knowledge and Associated Factors among United Arab Emirates University Students
Authors: Bashir Maryam M. , Ahmed Luai A. , Alshamsi Meera R. , Almahrooqi Sara , Alyammahi Taif , Alshehhi Shooq A. , Alhammadi Waad I. , Alhosani Hind A. , Alhammadi Fatima H. , Al-Rifai Rami H. , Al-Maskari Fatma
Published: July 2022

Gestational diabetes mellitus (GDM) burden is burgeoning globally. Correct knowledge about GDM among young people is paramount for timely prevention. This study assesses GDM knowledge and identifies factors associated with it among United Arab Emirates (UAE) University students. A validated self-administered questionnaire collected data from the university students. We analyzed the data for GDM knowledge status (ever heard of GDM) and GDM knowledge levels (poor, fair, and good) and conducted ordinal logistic regressions to assess for associated factors. A total of 735 students were surveyed with a mean age of 21.0 years. Of these, 72.8% had heard of GDM, and 52.9% of males versus 20.3% of female students had never heard of the condition before. Higher age (p = 0.019) and being a postgraduate student (p = 0.026) were associated with higher GDM knowledge status in males. GDM knowledge level analysis showed that 24.0%, 58.5%, and 17.5% had poor, fair, and good knowledge. The mean GDM-knowledge score was 6.3 ± 2.4 (out of 12). Being married [aOR-1.82 (95%CI 1.10–3.03)] and knowing someone who had GDM [aOR-1.78 (95%CI 1.23–2.60)] were independently associated with higher GDM knowledge levels among students. Students’ primary source of GDM knowledge was family/friends. There is an observed knowledge gap related to GDM among the students, especially males. This study urges the need to accelerate targeted GDM awareness campaigns among university students and the general population in the UAE.
The Non-Linear Impact of Financial Development on Environmental Quality and Sustainability: Evidence from G7 Countries
Authors: Ruza Cristina , Caro-Carretero Raquel
Published: July 2022

This paper analyses the impact of financial development on the environmental quality and sustainability for the group of G7 countries over the period 1990–2019 based on static panel data-fixed effect models. The objective is to explore if there exists a non-linear relationship between the whole financial system development and a wide array of measures of environmental sustainability and degradation, namely adjusted net savings, greenhouse gas, CO2, methane, nitrous oxide emissions and ecological footprint. We define a new Financial Environmental Kuznets Curve (FEKC) by introducing the square term of financial development on the environment-finance relationship. Empirical results prove the existence of non-linear relationships between the composite index of financial development and environmental degradation for the group of advanced economies. In the case of methane, we validate the presence of an inverted-U shape association in line with the FEKC hypothesis, while for greenhouse gas and CO2 the link follows a U-shaped pattern. The impact of financial development on environmental sustainability is monotonically positive and statistically significant while the ecological footprint is not statistically linked with the level of financial development within G7 countries. Economic growth, human capital, population density and primary energy consumption appear as significant drivers of environmental quality and sustainability.
Histological and Immunohistochemical Analysis of Peri-Implant Soft and Hard Tissues in Patients with Peri-Implantitis
Authors: Flores Valentina , Venegas Bernardo , Donoso Wendy , Ulloa Camilo , Chaparro Alejandra , Sousa Vanessa , Beltrán Víctor
Published: July 2022

Currently, researchers are focused on the study of cytokines as predictive biomarkers of peri-implantitis (PI) in order to obtain an early diagnosis and prognosis, and for treatment of the disease. The aim of the study was to characterize the peri-implant soft and hard tissues in patients with a peri-implantitis diagnosis. A descriptive observational study was conducted. Fifteen soft tissue (ST) samples and six peri-implant bone tissue (BT) samples were obtained from 13 patients who were diagnosed with peri-implantitis. All the samples were processed and embedded in paraffin for histological and immunohistochemical analyses. A descriptive and quantitative analysis of mast cells and osteocytes, A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF), osteonectin (ON), and ∝-smooth muscle actin (∝-SMA) was performed. We observed the presence of mast cells in peri-implant soft tissue in all samples (mean 9.21 number of mast cells) and osteocytes in peri-implant hard tissue in all samples (mean 37.17 number of osteocytes). The expression of APRIL-ST was 32.17% ± 6.39%, and that of APRIL-BT was 7.09% ± 5.94%. The BAFF-ST expression was 17.26 ± 12.90%, and the BAFF-BT was 12.16% ± 6.30%. The mean percentage of ON was 7.93% ± 3.79%, and ∝-SMA was 1.78% ± 3.79%. It was concluded that the expression of APRIL and BAFF suggests their involvement in the bone resorption observed in peri-implantitis. The lower expression of osteonectin in the peri-implant bone tissue can also be associated with a deficiency in the regulation of bone remodeling and the consequent peri-implant bone loss.
A Non-Cell-Autonomous Mode of DNA Damage Response in Soma of Caenorhabditis elegans
Authors: Dai Zhangyu , Zhang Wenjing , Shang Mengke , Tang Huangqi , Wu Lijun , Wu Yuejin , Wang Ting , Bian Po
Published: July 2022

Life has evolved a mechanism called DNA damage response (DDR) to sense, signal and remove/repair DNA damage, and its deficiency and dysfunction usually lead to genomic instability and development of cancer. The signaling mode of the DDR has been believed to be of cell-autonomy. However, the paradigm is being shifted with in-depth research into model organism Caenorhabditis elegans. Here, we mainly investigate the effect of DDR activation on the radiosensitivity of vulva of C. elegans, and first found that the vulval radiosensitivity is mainly regulated by somatic DDR, rather than the DDR of germline. Subsequently, the worm lines with pharynx-specific rescue of DDR were constructed, and it is shown that the 9-1-1-ATR and MRN-ATM cascades in pharynx restore approximately 90% and 70% of vulval radiosensitivity, respectively, through distantly regulating the NHEJ repair of vulval cells. The results suggest that the signaling cascade of DDR might also operate in a non-cell autonomous mode. To further explore the underlying regulatory mechanisms, the cpr-4 mutated gene is introduced into the DDR-rescued worms, and CPR-4, a cysteine protease cathepsin B, is confirmed to mediate the inter-tissue and inter-individual regulation of DDR as a signaling molecule downstream of 9-1-1-ATR. Our findings throw some light on the regulation of DNA repair in soma of C. elegans, and might also provide new cues for cancer prevention and treatment.
Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From Liquid Biopsy to New Omics Technologies and Noninvasive Circulating Biomarkers
Authors: Balistreri Carmela Rita
Published: July 2022

The endothelium has multiple functions, ranging from maintaining vascular homeostasis and providing nutrition and oxygen to tissues to evocating inflammation under adverse conditions and determining endothelial barrier disruption, resulting in dysfunction. Endothelial dysfunction represents a common condition associated with the pathogenesis of all diseases of the cardiovascular system, as well as of diseases of all of the other systems of the human body, including sepsis, acute respiratory distress syndrome, and COVID-19 respiratory distress. Such evidence is leading to the identification of potential biomarkers and therapeutic targets for preserving, reverting, or restoring endothelium integrity and functionality by promptly treating its dysfunction. Here, some strategies for achieving these goals are explored, despite the diverse challenges that exist, necessitating significant bench work associated with an increased number of clinical studies.
Extracellular Vesicles in Atrial Fibrillation—State of the Art
Authors: Procyk Grzegorz , Bilicki Dominik , Balsam Paweł , Lodziński Piotr , Grabowski Marcin , Gąsecka Aleksandra
Published: July 2022

Extracellular vesicles are particles released from cells and delimited by a lipid bilayer. They have been widely studied, including extensive investigation in cardiovascular diseases. Many scientists have explored their role in atrial fibrillation. Patients suffering from atrial fibrillation have been evidenced to present altered levels of these particles as well as changed amounts of their contents such as micro-ribonucleic acids (miRs). Although many observations have been made so far, a large randomized clinical trial is needed to assess the previous findings. This review aims to thoroughly summarize current research regarding extracellular vesicles in atrial fibrillation.
The Earliest Corotocini (Insecta: Coleoptera: Staphylinidae) from Dominican Amber, with Remarks on Post-Imaginal Growth Influence on Termitophile Taxonomy
Authors: Zilberman Bruno , Yin Zi-Wei , Cai Chen-Yang
Published: July 2022

Pareburniola dominicana Zilberman, Yin & Cai gen. et. sp. nov. is the very first fossil record of the tribe Corotocini, reported from Miocene Dominican Republic amber. The new species, which is based on a stenogastric individual, is described and illustrated and is included in the subtribe Corotocina due to the combination of a tarsal formula 4-4-4, an elongated gula, a developed labial palp, a reduced fourth palpomere, separated metacoxae and a glandular structure on the posterior region of the head. Since the taxon belongs to the physogastric tribe Corotocini, which presents post-imaginal growth, this phenomenon is herein discussed, and its current knowledge is used to understand the possible outcomes during morphological changes in the fossil species.