bluuebunny/crossref_metadata_2025 huggingface dataset:
Calabrian Goji vs. Chinese Goji: A Comparative Study on Biological Properties
Authors: Ruffo Mariarosa , Parisi Ortensia , Amone Fabio , Malivindi Rocco , Gorgoglione Domenico , De Biasio Filomena , Scrivano Luca , Pezzi Vincenzo , Puoci Francesco
Published: April 2017

Lycium barbarum (Goji) fruits are mainly cultivated in northwestern China and are well known for their beneficial and healthy effects. In this work, the biological and functional properties of Calabrian Goji extract, obtained from Goji berries cultivated in the Sibari Plain (in the Italian region of Calabria), were demonstrated. In order to evaluate the use of this extract as a food supplement for cognitive and mental disorders, the quantification of Carotenoids as Zeaxanthin equivalents was made. The antioxidant activity was investigated by evaluating the scavenging properties against 2,2′-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals and by performing the ORAC (Oxygen Radical Absorbance Capacity) assay. The inhibition of lipid peroxidation was quantified by bleaching test and the ability to inhibit acetylcholinesterase enzyme and to scavenge nitric oxide radical was also evaluated. All the results were compared to those obtained from a Chinese Goji extract used as a reference. Based on the reported data, Calabrian Goji might be used as a food supplement with a possible application in cognitive disorders, mental impairments and other neurodegenerative diseases, due to its biological properties and the high levels of Carotenoids.
Toward the Eco-Narrative: Rethinking the Role of Conflict in Storytelling
Authors: Donly Corinne
Published: April 2017

Offered as a response to the increasingly popular call within the eco-humanities for stories that will help humankind adapt to catastrophic planetary conditions, this article proposes “the eco-narrative”—an approach to storytelling that strives to compose with, not for, its nonhuman characters. An extension of eco-critical projects that analyze stories for their depictions of nonhumanity, the theoretical research herein brings ecological analysis of narrative to the level of structure. In particular, it problematizes the dominant plot model of conflict/climax/resolution, suggesting that stories motivated by conflict reinforce dualistic and anthropocentric habits for approaching the animal other. Evaluating two narratives concerning the human practice of killing animals—the Pew Commission’s report on Industrial Farm Animal Production and Annette Watson and Orville H. Huntington’s “They’re here—I can feel them”—the article observes how the former’s efforts at animal rights advocacy are undermined by its very storytelling framework. Celebrating the latter story’s more playful approach to narrative instead, the article ultimately suggests that a theory of “infinite play,” as developed by James P. Carse, can be used to re-envision the dominant plot model. A template for cooperation in the absence of known outcome, infinite play thus becomes the basis for the eco-narrative—a storytelling framework flexible enough to cocreate with nonhumanity, even during an environmental moment characterized by crisis.
Animal Poetry and Empathy
Authors: Brüggemann Tirza
Published: April 2017

This article discusses how our ideas of empathy are influenced by the dichotomy of mind versus body, also known as Cartesian dualism. Within the aesthetic field, this dichotomy is seen when researchers define narrative empathy as imaginatively reconstructing the fictional character’s thoughts and feelings. Conversely, the empathy aroused by a non-narrative work of art is seen as an unconscious bodily mirroring of movements, postures or moods. Thinking dualistically does not only have consequences for what we consider human nature; it also affects our view on animals. To show the untenability of dualistic thinking, this article focuses on the animal poetry genre. Using the ideas of the French phenomenologist Maurice Merleau-Ponty, I analyze two animal poems: “Inventing a Horse” by Meghan O’Rourke and “Spermaceti” by Les Murray. The analysis of these two poems suggests that the presiding ideas about aesthetic empathy and empathy in general need re-evaluation.
Troubadours & Troublemakers: Stirring the Network in Transmission & Anti-Transmission
Authors: Johnson Jeff T.
Published: April 2017

With reference to concepts developed in Trouble Songs: A Musicological Poetics, our objective is to locate trouble (and “trouble”) in and around song, while attending to media forms, transmission processes, and embodied figures that carry trouble through song. These figures include trouble singer, troubadour and DJ, where the latter combines the roles of media curator, Mixmaster and MC. An exploration of and through these interrelated figures serves to elaborate a theory of transmission and anti-transmission of trouble. In all cases we are concerned with the technology of trouble, as well as modes and techniques for its transmission.
Modeling Fire Occurrence at the City Scale: A Comparison between Geographically Weighted Regression and Global Linear Regression
Authors: Song Chao , Kwan Mei-Po , Zhu Jiping
Published: April 2017

An increasing number of fires are occurring with the rapid development of cities, resulting in increased risk for human beings and the environment. This study compares geographically weighted regression-based models, including geographically weighted regression (GWR) and geographically and temporally weighted regression (GTWR), which integrates spatial and temporal effects and global linear regression models (LM) for modeling fire risk at the city scale. The results show that the road density and the spatial distribution of enterprises have the strongest influences on fire risk, which implies that we should focus on areas where roads and enterprises are densely clustered. In addition, locations with a large number of enterprises have fewer fire ignition records, probably because of strict management and prevention measures. A changing number of significant variables across space indicate that heterogeneity mainly exists in the northern and eastern rural and suburban areas of Hefei city, where human-related facilities or road construction are only clustered in the city sub-centers. GTWR can capture small changes in the spatiotemporal heterogeneity of the variables while GWR and LM cannot. An approach that integrates space and time enables us to better understand the dynamic changes in fire risk. Thus governments can use the results to manage fire safety at the city scale.
Towards a Long-Term Strategy for Voluntary-Based Internal Radiation Contamination Monitoring: A Population-Level Analysis of Monitoring Prevalence and Factors Associated with Monitoring Participation Behavior in Fukushima, Japan
Authors: Nomura Shuhei , Tsubokura Masaharu , Ozaki Akihiko , Murakami Michio , Hodgson Susan , Blangiardo Marta , Nishikawa Yoshitaka , Morita Tomohiro , Oikawa Tomoyoshi
Published: April 2017

Following Japan’s 2011 Fukushima nuclear incident, we assessed voluntary-based monitoring behavior in Minamisoma City—located 10–40 km from the Fukushima nuclear plant—to inform future monitoring strategies. The monitoring in Minamisoma included occasional free of charge internal-radiation-exposure measurements. Out of around 70,000 individuals residing in the city before the incident, a total of 45,788 residents (female: 52.1%) aged ≥21 were evaluated. The monitoring prevalence in 2011–2012 was only 30.2%, and this decreased to 17.9% in 2013–2014. Regression analyses were performed to estimate factors associated with the monitoring prevalence and participation behavior. The results show that, in comparison with the age cohort of 21–30 years, the cohort of 71–80 and ≥81 years demonstrated significantly lower monitoring prevalence; female residents had higher monitoring prevalence than male residents; those who were living in evacuation zones at the time of the incident had higher monitoring prevalence than those who lived outside any of the evacuation zones; for those living outside Fukushima and neighboring Prefectures post-incident monitoring prevalence decreased significantly in 2013–2014. Our findings inform the discussion on the concepts of radiation risk perception and accessibility to monitoring and societal decision-making regarding the maintenance of the monitoring program with low monitoring prevalence. We also stress the possibility that the monitoring can work both to check that internal contamination levels are within acceptable limits, and as a risk communication tool, alleviating individuals’ concern and anxiety over radiation contamination.
Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand
Authors: Nishijo Muneko , Nambunmee Kowit , Suvagandha Dhitiwass , Swaddiwudhipong Witaya , Ruangyuttikarn Werawan , Nishino Yoshikazu
Published: April 2017

To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marker, was found to be associated with increased levels of parathyroid hormone, fractional excretion of calcium, and urinary/blood cadmium after adjusting for confounding factors in men. In women, urinary NTx was significantly associated with only urinary cadmium and a strong relationship with increased fractional excretion of calcium. Risk for bone metabolic disorders, indicated by high urinary NTx, significantly increased in men with blood cadmium ≥ 10 μg/L or urinary cadmium ≥ 10 μg/g creatinine. Increased osteocalcin level was significantly associated with increased blood cadmium in men. In conclusion, cadmium exposure appeared to have an influence on bone remodeling both bone resorption and formation in this population of older Thai men, and blood cadmium was more closely associated with bone metabolism than urinary cadmium.
Smoke-Free Laws and Hazardous Drinking: A Cross-Sectional Study among U.S. Adults
Authors: Jiang Nan , Gonzalez Mariaelena , Ling Pamela , Young-Wolff Kelly , Glantz Stanton
Published: April 2017

Tobacco and alcohol use are strongly associated. This cross-sectional study examined the relationship of smoke-free law coverage and smoke-free bar law coverage with hazardous drinking behaviors among a representative sample of U.S. adult drinkers (n = 17,057). We merged 2009 National Health Interview Survey data, American Nonsmokers’ Rights Foundation U.S. Tobacco Control Laws Database, and Census Population Estimates. Hazardous drinking outcomes included heavy drinking (>14 drinks/week for men; >7 drinks/week for women) and binge drinking (≥5 drinks on one or more days during past year). Chi-square tests compared hazardous drinking by sociodemographic factors. Multivariable logistic regression models were used to examine if smoke-free law and bar law coverages were associated with hazardous drinking, controlling for sociodemographics and smoking status. Subset analyses were conducted among drinkers who also smoked (n = 4074) to assess the association between law coverages and hazardous drinking. Among all drinkers, smoke-free law coverage was not associated with heavy drinking (adjusted odds ratio (AOR) = 1.22, 95% confidence interval (CI) = 0.99–1.50) or binge drinking (AOR = 1.09, 95% CI = 0.93–1.26). Smoke-free bar law coverage was also found to be unrelated to hazardous drinking. Similar results were found among those drinkers who smoked. Findings suggest that smoke-free laws and bar laws are not associated with elevated risk for alcohol-related health issues.
Lead Exposure Assessment among Pregnant Women, Newborns, and Children: Case Study from Karachi, Pakistan
Authors: Fatmi Zafar , Sahito Ambreen , Ikegami Akihiko , Mizuno Atsuko , Cui Xiaoyi , Mise Nathan , Takagi Mai , Kobayashi Yayoi , Kayama Fujio
Published: April 2017

Lead (Pb) in petrol has been banned in developed countries. Despite the control of Pb in petrol since 2001, high levels were reported in the blood of pregnant women and children in Pakistan. However, the identification of sources of Pb has been elusive due to its pervasiveness. In this study, we assessed the lead intake of pregnant women and one- to three-year-old children from food, water, house dust, respirable dust, and soil. In addition, we completed the fingerprinting of the Pb isotopic ratios (LIR) of petrol and secondary sources (food, house-dust, respirable dust, soil, surma (eye cosmetics)) of exposure within the blood of pregnant women, newborns, and children. Eight families, with high (~50 μg/dL), medium (~20 μg/dL), and low blood levels (~10 μg/dL), were selected from 60 families. The main sources of exposure to lead for children were food and house-dust, and those for pregnant women were soil, respirable dust, and food. LIR was determined by inductively coupled plasma quadrupole mass spectrometry (ICP-QMS) with a two sigma uncertainty of ±0.03%. The LIR of mothers and newborns was similar. In contrast, surma, and to a larger extent petrol, exhibited a negligible contribution to both the child’s and mother’s blood Pb. Household wet-mopping could be effective in reducing Pb exposure. This intake assessment could be replicated for other developing countries to identify sources of lead and the burden of lead exposure in the population.
An Improved Density-Based Time Series Clustering Method Based on Image Resampling: A Case Study of Surface Deformation Pattern Analysis
Authors: Liu Yaolin , Wang Xiaomi , Liu Qiliang , Chen Yiyun , Liu Leilei
Published: April 2017

Time series clustering algorithms have been widely used to mine the clustering distribution characteristics of real phenomena. However, these algorithms have several limitations. First, they depend heavily on prior knowledge. Second, the algorithms do not simultaneously consider the similarity of spatial locations, spatial-temporal attribute values, and spatial-temporal attribute trends (trends in terms of the change direction and ranges in addition and deletion over time), which are all important similarity measurements. Finally, the calculation cost based on these methods for clustering analysis is becoming increasingly computationally demanding, because the data volume of the image time series data is increasing. In view of these shortcomings, an improved density-based time series clustering method based on image resampling (DBTSC-IR) has been proposed in this paper. The proposed DBTSC-IR has two major parts. In the first part, an optimal resampling scale of the image time series data is first determined to reduce the data volume by using a new scale optimization function. In the second part, the traditional density-based time series clustering algorithm is improved by introducing a density indicator to control the clustering sequences by considering the spatial locations, spatial-temporal attribute values, and spatial-temporal attribute trends. The final clustering analysis is then performed directly on the resampled image time series data by using the improved algorithm. Finally, the effectiveness of the proposed DBTSC-IR is illustrated by experiments on both the simulated datasets and in real applications. The proposed method can effectively and adaptively recognize the spatial patterns with arbitrary shapes of image time series data with consideration of the effects of noise.
Lysozyme Associated Liposomal Gentamicin Inhibits Bacterial Biofilm
Authors: Hou Yilin , Wang Zhaojie , Zhang Peng , Bai Hu , Sun Yuelin , Duan Jinyou , Mu Haibo
Published: April 2017

Bacteria on living or inert surfaces usually form biofilms which make them highly resistant to antibiotics and immune clearance. Herein, we develop a simple approach to overcome the above conundrum through lysozyme-associated liposomal gentamicin (LLG). The association of lysozyme to the surface of liposomes can effectively reduce the fusion of liposomes and undesirable payload release in regular storage or physiological environments. The LLG was more effective at damaging established biofilms and inhibiting biofilm formation of pathogens including Gram-positive and Gram-negative bacteria than gentamicin alone. This strategy may provide a novel approach to treat infections due to bacterial biofilm.
Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo
Authors: Li Yan , Wu Yannan , Yao Xinlei , Hao Fang , Yu Chunlei , Bao Yongli , Wu Yin , Song Zhenbo , Sun Ying , Zheng Lihua , Wang Guannan , Huang Yanxin , Sun Luguo , Li Yuxin
Published: April 2017

Ginkgolide A (GA) is a natural compound isolated from Ginkgo biloba and has been used to treat cardiovascular diseases and diabetic vascular complications. However, only a few studies have been conducted on the anti-inflammatory effects of GA. In particular, no related reports have been published in a common inflammation model of lipopolysaccharide (LPS)-stimulated macrophages, and the anti-inflammatory mechanisms of GA have not been fully elucidated. In the present study, we extensively investigated the anti-inflammatory potential of GA in vitro and in vivo. We showed that GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro. These effects were partially carried out via downregulating Nuclear factor kappa-B (NF-κB), Mitogen-activated protein kinases (MAPKs) (p38 mitogen-activated protein kinase and extracellular signal-regulated kinase (ERK), but not c-Jun N-terminal kinase (JNK), and activating the AMP-activated protein kinase (AMPK) signaling pathway also seems to be important. Consistently, GA was also shown to inhibit the LPS-stimulated release of TNF-α and IL-6 in mice. Taken together, these findings suggest that GA can serve as an effective inflammatory inhibitor in vitro and in vivo.
Liposomal Encapsulation for Systemic Delivery of Propranolol via Transdermal Iontophoresis Improves Bone Microarchitecture in Ovariectomized Rats
Authors: Teong Benjamin , Kuo Shyh , Tsai Wei-Hsin , Ho Mei-Ling , Chen Chung-Hwan , Huang Han
Published: April 2017

The stimulatory effects of liposomal propranolol (PRP) on proliferation and differentiation of human osteoblastic cells suggested that the prepared liposomes-encapsulated PRP exerts anabolic effects on bone in vivo. Iontophoresis provides merits such as sustained release of drugs and circumvention of first pass metabolism. This study further investigated and evaluated the anti-osteoporotic effects of liposomal PRP in ovariectomized (OVX) rats via iontophoresis. Rats subjected to OVX were administered with pure or liposomal PRP via iontophoresis or subcutaneous injection twice a week for 12 weeks. Changes in the microarchitecture at the proximal tibia and the fourth lumbar spine were assessed between pure or liposomal PRP treated and non-treated groups using micro-computed tomography. Administration of liposomal PRP at low dose (0.05 mg/kg) via iontophoresis over 2-fold elevated ratio between bone volume and total tissue volume (BV/TV) in proximal tibia to 9.0% whereas treatment with liposomal PRP at low and high (0.5 mg/kg) doses via subcutaneous injection resulted in smaller increases in BV/TV. Significant improvement of BV/TV and bone mineral density (BMD) was also found in the fourth lumbar spine when low-dose liposomal PRP was iontophoretically administered. Iontophoretic low-dose liposomal PRP also elevated trabecular numbers in tibia and trabecular thickness in spine. Enhancement of bone microarchitecture volumes has highlighted that liposomal formulation with transdermal iontophoresis is promising for PRP treatment at the lower dose and with longer duration than its clinical therapeutic range and duration to exhibit optimal effects against bone loss in vivo.
Behavior of Human Osteoblast Cells Cultured on Titanium Discs in Relation to Surface Roughness and Presence of Melatonin
Authors: Sola-Ruiz M. , Perez-Martinez Carolina , Labaig-Rueda Carlos , Carda Carmen , Martín De Llano J.
Published: April 2017

The aim of this work was to observe the behavior of osteoblast cells cultured in vitro on titanium discs in relation to disc surface roughness and the addition of melatonin to the culture medium. MG63 osteoblast cells were cultivated on 120 Grade 5 Ti divided into three groups: Group E, treated with dual acid etch; Group EP, treated with dual acid etch and calcium phosphate; and Group M, machined. Surface roughness was examined under a laser scanning confocal microscope (CLSM) and scanning electron microscopy (SEM). The proliferation and morphology of cells were determined under fluorescence microscopy and SEM. Messenger ribonucleic acid (mRNA) of different genes related to osteoblastic differentiation was quantified by means of real-time quantitative polymerase chain reaction (RT-PCR) assay. The greatest surface roughness was found in Group EP (Ra 0.354 µm), followed by Group E (Ra 0.266 µm), and Group M (Ra 0.131 µm), with statistically significant differences between the groups (p < 0.001). In the presence of melatonin a trend to a higher cell proliferation was observed in all groups although significant differences were only found in Group M (p = 0.0079). Among the genes studied, a significant increase in phosphate-regulating neutral endopeptidase, X-linked (PHEX) expression was observed in cells cultured on EP discs. The addition of melatonin increased osteoblast cell proliferation and differentiation, and may favor the osseointegration of dental implants.
Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride
Authors: Macirella Rachele , Brunelli Elvira
Published: April 2017

Mercury (Hg) is a global pollutant that may exert its toxic effects on living organisms and is found in both aquatic and terrestrial ecosystems in three chemical forms; elemental, organic, and inorganic. The inorganic form (iHg) tends to predominantly accumulate in aquatic environments. The gill apparatus is a very dynamic organ that plays a fundamental role in gas exchange, osmoregulation, acid-base regulation, detoxification, and excretion, and the gills are the primary route of waterborne iHg entrance in fish. In the present work we investigated the morphofunctional and ultrastructural effects in Danio rerio gills after 96 h exposure to two low HgCl2 concentrations (7.7 and 38.5 µg/L). Our results clearly demonstrated that a short-term exposure to low concentrations of mercury chloride resulted in gill morphology alterations and in the modifications of both Na+/K+-ATPase and metallothioneins (MTs) expression pattern. The main morphological effects recorded in this work were represented by hyperplasia and ectopia of chloride cells (CCs), lamellar fusion, increased mucous secretion, alteration of pavement cells (PVCs), detachment of the secondary epithelium, pillar cell degeneration, degeneration, and apoptosis. Trough immunohistochemistry and real-time PCR analysis also showed a dose-related modulation of Na+/K+-ATPase and MTs.
Subcellular Localization of Arabidopsis Pathogenesis-Related 1 (PR1) Protein
Authors: Pečenková Tamara , Pleskot Roman , Žárský Viktor
Published: April 2017

The Arabidopsis thaliana pathogenesis-related 1 (PR1) is an important defense protein, so far it has only been detected in extracellular space and its subcellular sorting and transport remain unexplained. Using a green fluorescent protein (GFP) tagged full length, as well as a C-terminus truncated version of PR1, we observed that when expressed ectopically in Nicotiana benthamiana leaves, PR1 co-localizes only partially with Golgi markers, and much more prominently with the late endosome (LE)/multivesicular body (MVB) FYVE marker. The C-truncated version PR1ΔC predominantly localized to the endoplasmic reticulum (ER). The same localizations were found for stable Arabidopsis transformants with expression of PR1 and PR1ΔC driven by the native promoter. We conclude that the A. thaliana PR1 (AtPR1) undergoes an unconventional secretion pathway, starting from the C-terminus-dependent sorting from the ER, and utilizing further transportation via phosphatidyl-inositol-3-phosphate (PI(3)P) positive LE/MVB-like vesicles. The homology model of the PR1 structure shows that the cluster of positively charged amino acid residues (arginines 60, 67, 137, and lysine 135) could indeed interact with negatively charged phospholipids of cellular membranes. It remains to be resolved whether Golgi and LE/MVB localization reflects an alternative sorting or trafficking succession, and what the role of lipid interactions in it will be.
Is There any Alternative to Canonical DNA Barcoding of Multicellular Eukaryotic Species? A Case for the Tubulin Gene Family
Authors: Breviario Diego
Published: April 2017

Modern taxonomy is largely relying on DNA barcoding, a nucleotide sequence-based approach that provides automated species identification using short orthologous DNA regions, mainly of organellar origin when applied to multicellular Eukaryotic species. Target DNA loci have been selected that contain a minimal amount of nucleotide sequence variation within species while diverging among species. This strategy is quite effective for the identification of vertebrates and other animal lineages but poses a problem in plants where different combinations of two or three loci are constantly used. Even so, species discrimination in such plant categories as ornamentals and herbals remain problematic as well as the confident identification of subspecies, ecotypes, and closely related or recently evolved species. All these limitations may be successfully solved by the application of a different strategy, based on the use of a multi-locus, ubiquitous, nuclear marker, that is tubulin. In fact, the tubulin-based polymorphism method can release specific genomic profiles to any plant species independently from its taxonomic group. This offers the rare possibility of an effective yet generic genomic fingerprint. In a more general context, the issue is raised about the possibility that approaches alternative to systematic DNA sequencing may still provide useful and simple solutions.
Social Media Providing an International Virtual Elective Experience for Student Nurses
Authors: Procter Paula M. , Brixey Juliana J. , Todhunter Fern , Honey Michelle L. L.
Published: April 2017

The advances in social media offer many opportunities for developing understanding of different countries and cultures without any implications of travel. Nursing has a global presence and yet it appears as though students have little knowledge of the health and social care needs and provision outside their local environment. Our collaboration across three countries, New Zealand, United Kingdom, and the United States of America, brought the two themes together with the aim of senior student nurses having a communication channel to explore public health issues in each country. Using a closed Facebook™ page, third year undergraduate adult nursing students were invited to take part in a three month pilot study to test the feasibility of virtual collaboration through exchanging public health issues. Here we report upon the collaboration, operation of the social media, and main findings of the study. Three core areas will be reported upon, these being the student’s views of using social media for learning about international perspectives of health, seeing nursing as a global profession and recommendations for future development of this positively reviewed learning technique. To conclude consideration will be given to further development of this work by the collaborative team expanding the countries involved.
Multi-Time-Scale Simulation Tool for Renewable Energy Integration Analysis in Distribution Circuits
Authors: Chirapongsananurak Pisitpol , Santoso Surya
Published: April 2017

This paper develops a distribution circuit multi-time-scale simulation tool for applications in wind turbine and photovoltaic (PV) integration analysis. The proposed simulation tool developed in MATLAB™ includes several distribution circuit components, such as voltage sources, distribution lines, transformers, loads, capacitor banks, wind turbines and PVs. Each equipment consists of three models for simulations in three different time scales, i.e., steady-state, electromechanical transient and electromagnetic transient models. Therefore, the proposed tool is able to perform a long-term simulation involving power system phenomena spreading across time scales. The test circuits employed to perform multi-time-scale simulation in this paper are modified from the IEEE four-node test feeder. The simulation scenarios include wind speed and solar irradiance ramp up and down; a capacitor bank is energized and de-energized; and a single-line-to-ground fault occurs and clears itself. The simulation results show that the proposed tool is capable of evaluating power system phenomena spread across time scales.
Reduced Multidrug Susceptibility Profile Is a Common Feature of Opportunistic Fusarium Species: Fusarium Multi-Drug Resistant Pattern
Authors: Taj-Aldeen Saad
Published: April 2017

The resistance among various opportunistic Fusarium species to different antifungal agents has emerged as a cause of public health problems worldwide. Considering the significance of multi-drug resistant (MDR), this paper emphasizes the problems associated with MDR and the need to understand its clinical significance to combat microbial infections. The search platform PubMed/MEDLINE and a review of 32 cases revealed a common multidrug-resistant profile exists, and clinically relevant members of Fusarium are intrinsically resistant to most currently used antifungals. Dissemination occurs in patients with prolonged neutropenia, immune deficiency, and especially hematological malignancies. Amphotericin B displayed the lowest minimum inhibitory concentrarions (MICs) followed by voriconazole, and posaconazole. Itraconazole and fluconazole showed high MIC values, displaying in vitro resistance. Echinocandins showed the highest MIC values. Seven out of ten (70%) patients with neutropenia died, including those with fungemia that progressed to skin lesions. Clinical Fusarium isolates displayed a common MDR profile and high MIC values for the most available antifungal agents with species- and strain-specific differences in antifungal susceptibility. Species identification of Fusarium infections is important. While the use of natamycin resulted in a favorable outcome in keratitis, AmB and VRC are the most used agents for the treatment of fusariosis in clinical settings.
Creep Behavior of Poly(lactic acid) Based Biocomposites
Authors: Morreale Marco , Mistretta Maria , Fiore Vincenzo
Published: April 2017

Polymer composites containing natural fibers are receiving growing attention as possible alternatives for composites containing synthetic fibers. The use of biodegradable matrices obtained from renewable sources in replacement for synthetic ones is also increasing. However, only limited information is available about the creep behavior of the obtained composites. In this work, the tensile creep behavior of PLA based composites, containing flax and jute twill weave woven fabrics, produced through compression molding, was investigated. Tensile creep tests were performed at different temperatures (i.e., 40 and 60 °C). The results showed that the creep behavior of the composites is strongly influenced by the temperature and the woven fabrics used. As preliminary characterization, quasi-static tensile tests and dynamic mechanical tests were carried out on the composites. Furthermore, fabrics (both flax and jute) were tested as received by means of quasi-static tests and creep tests to evaluate the influence of fabrics mechanical behavior on the mechanical response of the resulting composites. The morphological analysis of the fracture surface of the tensile samples showed the better fiber-matrix adhesion between PLA and jute fabric.
The Brittleness and Chemical Stability of Optimized Geopolymer Composites
Authors: Steinerova Michaela , Matulova Lenka , Vermach Pavel , Kotas Jindrich
Published: April 2017

Geopolymers are known as high strength and durable construction materials but have a brittle fracture. In practice, this results in a sudden collapse at ultimate load, without any chance of preventing the breakdown of parts or of withstanding the stress for some time. Glass fiber usage as a total anisotropic shape acting as a compact structure component should hinder the fracture mechanism. The optimized compositions in this study led to a significant reinforcement, especially in the case of flexural strength, but also in terms of the compressive strength and notch toughness. The positive and negative influence of the fibers on the complex composite properties provided chemical stability.
In Vitro Antioxidant Activities of Enzymatic Hydrolysate from Schizochytrium sp. and Its Hepatoprotective Effects on Acute Alcohol-Induced Liver Injury In Vivo
Authors: Cai Xixi , Yan Ana , Fu Nanyan , Wang Shaoyun
Published: April 2017

Schizochytrium protein hydrolysate (SPH) was prepared through stepwise enzymatic hydrolysis by alcalase and flavourzyme sequentially. The proportion of hydrophobic amino acids of SPH was 34.71%. The molecular weight (MW) of SPH was principally concentrated at 180–3000 Da (52.29%). SPH was divided into two fractions by ultrafiltration: SPH-I (MW < 3 kDa) and SPH-II (MW > 3 kDa). Besides showing lipid peroxidation inhibitory activity in vitro, SPH-I exhibited high DPPH and ABTS radicals scavenging activities with IC50 of 350 μg/mL and 17.5 μg/mL, respectively. In addition, the antioxidant activity of SPH-I was estimated in vivo using the model of acute alcohol-induced liver injury in mice. For the hepatoprotective effects, oral administration of SPH-I at different concentrations (100, 300 mg/kg BW) to the mice subjected to alcohol significantly decreased serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and hepatic malondialdehyde (MDA) level compared to the untreated mice. Besides, SPH-I could effectively restore the hepatic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities and glutathione (GSH) level. Results suggested that SPH was rich in biopeptides that could be exploited as antioxidant molecules against oxidative stress in human body.
Foulant Analysis of Three RO Membranes Used in Treating Simulated Brackish Water of the Iraqi Marshes
Authors: Sachit Dawood , Veenstra John
Published: April 2017

In this work, three different types of Reverse Osmosis (RO) (Thin-Film Composite (SE), Cellulose Acetate (CE), and Polyamide (AD)) were used to perform foulant analysis (autopsy) study on the deposited materials from three different simulated brackish surface feed waters. The brackish surface water qualities represented the water quality in Iraqi marshes. The main foulants from the simulated feed waters were characterized by using Scanning Electron Microscope (SEM) images and Energy-Dispersive X-ray Spectroscopy (EDXS) spectra. The effect of feed water temperatures (37 °C and 11 °C) on the formation of the fouled material deposited on the membrane surface was examined in this study. Also, pretreatment by a 0.1 micron microfiltration (MF) membrane of the simulated feed water in advance of the RO membrane on the precipitated material on the membrane surface was investigated. Finally, Fourier Transform Infrared Spectroscopy (FTIR) analysis was used to identify the functional groups of the organic matter deposited on the RO membrane surfaces. The SEM images and EDSX spectra suggested that the fouled material was mainly organic matter, and the major crystal deposited on the RO membrane was calcium carbonate (CaCO3). The FTIR spectra of the fouled RO membranes suggested that the constituents of the fouled material included aliphatic and aromatic compounds.
Screening, Purification and Characterization of Anionic Antimicrobial Proteins from Foeniculum Vulgare
Authors: Al Akeel Raid , Mateen Ayesha , Syed Rabbani , Alyousef Abdullah , Shaik Mohammed
Published: April 2017

Foeniculum vulgare Mill., commonly called fennel, is a medicinal plant belonging to the Umbelliferae (Apiaceae) family, and is used in traditional medicine. Antibacterial peptides were isolated using sodium phosphate citrate buffer and, for extraction, cetyltrimethyl ammonium bromide (CTAB) buffer with pH 6, have been employed and antimicrobial activity tested against four reference strains. The extracted protein was subjected to 3 kDa dialysis and separation was carried out by DEAE-ion exchange chromatography and further proteins were identified by 2D gel electrophoresis. The results of Foeniculum vulgare elutes obtained from DEAE-ion exchange chromatography were tested for antibacterial activity. Elute 3 shows the highest antibacterial activity on Pseudomonas aeruginosa with a diameter of a zone of inhibition of 16 mm and IC50 value 25.02 (mcg/mL). Based on the findings of the wide usage in treatment of various ailments and day-to-day life, Foeniculum vulgare seeds were used in the present research and have shown promising antibacterial effects, which requires further proteomic research to authenticate the role of the anticipated proteins.
Thermo-Oxidative Stability Evaluation of Bullfrog (Rana catesbeiana Shaw) Oil
Authors: Rutckeviski Renata , Xavier-Júnior Francisco , Morais Andreza , Alencar Éverton , Amaral-Machado Lucas , Genre Julieta , Gondim Amanda , Egito Eryvaldo
Published: April 2017

Bullfrog oil (BO), a natural product obtained from recycling of adipose tissue from the amphibian Rana catesbeiana Shaw, has been recently evaluated as a therapeutic activity ingredient. This work aimed to evaluate the long-term and accelerated thermal oxidative stabilities of this product, which is a promising raw material for emulsion technology development. BO was extracted from amphibian adipose tissue at 70 °C with a yield of 60% ± 0.9%. Its main fatty acid compounds were oleic (30.0%) and eicosapentaenoic (17.6%) acids. Using titration techniques, BO showed peroxide, acid, iodine and saponification indices of 1.92 mEq·O2/kg, 2.95 mg·KOH/g oil, 104.2 g I2/100 g oil and 171.2 mg·KOH/g oil, respectively. In order to improve the accelerated oxidative stability of BO, synthetic antioxidants butylhydroxytoluene (BHT) and buthylhydroxyanisole (BHA) were used. The addition of BHT increased the oxidation induction time compared to the pure oil, or the oil containing BHA. From the results, the best oil-antioxidant mixture and concentration to increase the oxidative stability and allow the oil to be a stable raw material for formulation purposes was derived.
Associations of Dietary Glucose, Fructose, and Sucrose with β-Cell Function, Insulin Sensitivity, and Type 2 Diabetes in the Maastricht Study
Authors: Biggelaar Louise J. C. J. den , Eussen Simone J. P. M. , Sep Simone J. S. , Mari Andrea , Ferrannini Ele , Dongen Martien C. J. M. van , Denissen Karlijn F. M. , Wijckmans Nicole E. G. , Schram Miranda T. , Kallen Carla J. van der , Koster Annemarie , Schaper Nicolaas , Henry Ronald M. A. , Stehouwer Coen D. A. , Dagnelie Pieter C.
Published: April 2017

The associations of glucose, fructose, and sucrose intake with type 2 diabetes mellitus (T2DM) have been inconsistent. Furthermore, there is a lack of studies focusing on early markers of T2DM that provide insight into the process of T2DM progression: impaired pancreatic β-cell function (BCF) and insulin sensitivity. This study evaluated associations cross-sectionally in a population-based cohort consisting of 2818 individuals (mean ± SD age 59.7 ± 8.18, 49.5% male, n = 120 newly diagnosed T2DM). Glucose, fructose, and sucrose intake were assessed by a food frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-points oral glucose tolerance test. Linear regression analysis revealed a positive association of glucose intake with insulin sensitivity in the fully adjusted model (standardized beta (95% CI) 0.07 (0.05, 0.14) SD for ≥23 g vs. <10 g of glucose). Fructose and sucrose intake were not associated with insulin sensitivity after full adjustments. In addition, no associations of dietary glucose, fructose, and sucrose with BCF were detected. In conclusion, higher intake of glucose, not fructose and sucrose, was associated with higher insulin sensitivity, independent of dietary fibre. No convincing evidence was found for associations of dietary glucose, fructose, and sucrose with BCF in this middle-aged population.
Polarization Characterization of Soft X-Ray Radiation at FERMI FEL-2
Authors: Roussel Eléonore , Allaria Enrico , Callegari Carlo , Coreno Marcello , Cucini Riccardo , Mitri Simone , Diviacco Bruno , Ferrari Eugenio , Finetti Paola , Gauthier David , Penco Giuseppe , Raimondi Lorenzo , Svetina Cristian , Zangrando Marco , Beckmann Andreas , Glaser Leif , Hartmann Gregor , Scholz Frank , Seltmann Joern , Shevchuk Ivan , Viefhaus Jens , Giannessi Luca
Published: April 2017

The control of polarization state in soft and hard X-ray light is of crucial interest to probe structural and symmetry properties of matter. Thanks to their Apple-II type undulators, the FERMI-Free Electron Lasers are able to provide elliptical, circular or linearly polarized light within the extreme ultraviolet and soft X-ray range. In this paper, we report the characterization of the polarization state of FERMI FEL-2 down to 5 nm. The results show a high degree of polarization of the FEL pulses, typically above 95%. The campaign of measurements was performed at the Low Density Matter beamline using an electron Time-Of-Flight based polarimeter.
Enhancing Singapore’s Pension Scheme: A Blueprint for Further Flexibility
Authors: Kwong Koon-Shing , Tse Yiu-Kuen , Chan Wai-Sum
Published: April 2017

Building a social security system to ensure Singapore residents have peace of mind in funding for retirement has been at the top of Singapore government’s policy agenda over the last decade. Implementation of the Lifelong Income For the Elderly (LIFE) scheme in 2009 clearly shows that the government spares no effort in improving its pension scheme to boost its residents’ income after retirement. Despite the recent modifications to the LIFE scheme, Singapore residents must still choose between two plans: the Standard and Basic plans. To enhance the flexibility of the LIFE scheme with further streamlining of its fund management, we propose some plan modifications such that scheme members do not face a dichotomy of plan choices. Instead, they select two age parameters: the Payout Age and the Life-annuity Age. This paper discusses the actuarial analysis for determining members’ payouts and bequests based on the proposed age parameters. We analyze the net cash receipts and Internal Rate of Return (IRR) for various plan-parameter configurations. This information helps members make their plan choices. To address cost-of-living increases we propose to extend the plan to accommodate an annual step-up of monthly payouts. By deferring the Payout Age from 65 to 68, members can enjoy an annual increase of about 2% of the payouts for the same first-year monthly benefits.
Turbidity in Apalachicola Bay, Florida from Landsat 5 TM and Field Data: Seasonal Patterns and Response to Extreme Events
Authors: Joshi Ishan D. , D’Sa Eurico J. , Osburn Christopher L. , Bianchi Thomas S.
Published: April 2017

Synoptic monitoring of estuaries, some of the most bio-diverse and productive environments on Earth, is essential to study small-scale water dynamics and its role on spatiotemporal variation in water quality important to indigenous marine species and surrounding human settlements. We present a detailed study of turbidity, an optical index of water quality, in Apalachicola Bay, Florida (USA) using historical in situ measurements and Landsat 5 TM data archive acquired from 2004 to 2011. Data mining techniques such as time-series decomposition, principal component analysis, and classification tree-based models were utilized to decipher time-series for examining variations in physical forcings, and their effects on diurnal and seasonal variability in turbidity in Apalachicola Bay. Statistical analysis showed that the bay is highly dynamic in nature, both diurnally and seasonally, and its water quality (e.g., turbidity) is largely driven by interactions of different physical forcings such as river discharge, wind speed, tides, and precipitation. River discharge and wind speed are the most influential forcings on the eastern side of river mouth, whereas all physical forcings were relatively important to the western side close to the major inlet, the West Pass. A bootstrap-optimized and atmospheric-corrected single-band empirical relationship (Turbidity (NTU) = 6568.23 × (Reflectance (Band 3))1.95; R2 = 0.77 ± 0.06, range = 0.50–0.91, N = 50) is proposed with seasonal thresholds for its application in various seasons. The validation of this relationship yielded R2 = 0.70 ± 0.15 (range = −0.96–0.97; N = 38; RMSE = 7.78 ± 2.59 NTU; Bias (%) = −8.70 ± 11.48). Complex interactions of physical forcings and their effects on water dynamics have been discussed in detail using Landsat 5 TM-based turbidity maps during major events between 2004 and 2011. Promising results of the single-band turbidity algorithm with Landsat 8 OLI imagery suggest its potential for long-term monitoring of water turbidity in a shallow water estuary such as Apalachicola Bay.
SAW Sensors for Chemical Vapors and Gases
Authors: Devkota Jagannath , Ohodnicki Paul , Greve David
Published: April 2017

Surface acoustic wave (SAW) technology provides a sensitive platform for sensing chemicals in gaseous and fluidic states with the inherent advantages of passive and wireless operation. In this review, we provide a general overview on the fundamental aspects and some major advances of Rayleigh wave-based SAW sensors in sensing chemicals in a gaseous phase. In particular, we review the progress in general understanding of the SAW chemical sensing mechanism, optimization of the sensor characteristics, and the development of the sensors operational at different conditions. Based on previous publications, we suggest some appropriate sensing approaches for particular applications and identify new opportunities and needs for additional research in this area moving into the future.
A Multi-Sensorial Simultaneous Localization and Mapping (SLAM) System for Low-Cost Micro Aerial Vehicles in GPS-Denied Environments
Authors: López Elena , García Sergio , Barea Rafael , Bergasa Luis , Molinos Eduardo , Arroyo Roberto , Romera Eduardo , Pardo Samuel
Published: April 2017

One of the main challenges of aerial robots navigation in indoor or GPS-denied environments is position estimation using only the available onboard sensors. This paper presents a Simultaneous Localization and Mapping (SLAM) system that remotely calculates the pose and environment map of different low-cost commercial aerial platforms, whose onboard computing capacity is usually limited. The proposed system adapts to the sensory configuration of the aerial robot, by integrating different state-of-the art SLAM methods based on vision, laser and/or inertial measurements using an Extended Kalman Filter (EKF). To do this, a minimum onboard sensory configuration is supposed, consisting of a monocular camera, an Inertial Measurement Unit (IMU) and an altimeter. It allows to improve the results of well-known monocular visual SLAM methods (LSD-SLAM and ORB-SLAM are tested and compared in this work) by solving scale ambiguity and providing additional information to the EKF. When payload and computational capabilities permit, a 2D laser sensor can be easily incorporated to the SLAM system, obtaining a local 2.5D map and a footprint estimation of the robot position that improves the 6D pose estimation through the EKF. We present some experimental results with two different commercial platforms, and validate the system by applying it to their position control.