bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Learning-Based Intelligent Robot in Sentencing
Authors: Chen Xuan
Published: July 2022

This work aims to explore the application of deep learning-based artificial intelligence technology in sentencing, to promote the reform and innovation of the judicial system. First, the concept and the principles of sentencing are introduced, and the deep learning model of intelligent robot in trials is proposed. According to related concepts, the issues that need to be solved in artificial intelligence sentencing based on deep learning are introduced. The deep learning model is integrated into the intelligent robot system, to assist in the sentencing of cases. Finally, an example is adopted to illustrate the feasibility of the intelligent robot under deep learning in legal sentencing. The results show that the general final trial periods for cases of traffic accidents, copyright information, trademark infringement, copyright protection, and theft are 1,049, 796, 663, 847, and 201 days, respectively; while the final trial period under artificial intelligence evaluation based on the restricted Boltzmann deep learning model is 458, 387, 376, 438, and 247 days, respectively. The accuracy of trials is above 92%, showing a high application value. It can be observed that expect theft cases, the final trial period for others cases has been effectively reduced. The intelligent robot assistance under the restricted Boltzmann deep learning model can shorten the trial period of cases. The deep learning intelligent robot has a certain auxiliary role in legal sentencing, and this outcome provides a theoretical basis for the research of artificial intelligence technology in legal sentencing.
Validation of the Tunisian Empathy Scale for Children (TESC) in General Population and Children With Autism Spectrum Disorder
Authors: Ben Youssef Hela , Halayem Soumeyya , Ghazzai Malek , Jelili Selima , Ben Mansour Hager , Rajhi Olfa , Taamallah Amal , Ennaifer Selima , Hajri Malek , Abbes Zeineb Salma , Fakhfakh Radhouane , Nabli Ahmed , Bouden Asma
Published: July 2022

Background

Several empathy assessment tests have been proposed worldwide but none of them took into account cultural variations that seem to affect empathic manifestations. The aim of this study was to create and validate an empathy assessment questionnaire for school-aged Tunisian children entitled “Tunisian Empathy Scale for Children” (TESC).

Methods

An evaluative cross-sectional study was conducted. The questionnaire was administered to parents of 197 neuro-typical children and 31 children with autism without associated intellectual deficits, aged between 7 and 12 years. Validation steps included: face validity, content validity, construct validity, and reliability study. A ROC curve analysis was used to investigate the diagnostic performance of the TESC.

Results

Face validity was verified with an expert panel. Content validity was examined, and 11 items were removed as irrelevant or not assessable by parents. Exploratory factor analysis extracted four domains that explained 43% of the total variance. All these domains were significantly correlated with the total score (p < 10−3) and are, respectively: empathic behaviors, affective empathy, cognitive empathy, and a combined affective and cognitive domain. The reliability study showed a satisfactory level of internal consistency of the TESC, with a Cronbach's alpha of 0.615.

The diagnostic performance of the TESC in relation to autism was evaluated by the ROC curve with a sensitivity and specificity of 84.3 and 62.1%, respectively, for a total score of 16.

Conclusion

A 15-item questionnaire assessing empathy in a multidimensional and culturally adapted way was obtained. The psychometric qualities of the TESC were satisfactory.
Improving Recovery of Irritant Hand Dermatitis in Healthcare Workers With Workplace Interventions During the COVID-19 Pandemic
Authors: Loi Alicia S. T. , Aribou Zeenathnisa M. , Fong Yuke Tien
Published: July 2022

Introduction:

Occupational hand dermatitis is common among healthcare workers, with increased incidence during the COVID-19 pandemic. Irritant contact dermatitis accounts for the majority of occupational hand dermatitis and is largely due to frequent contact with hand hygiene products. Long-term prognosis of occupational contact dermatitis is often very poor. This study aims to identify and implement suitable workplace interventions to aid in the recovery of occupational irritant hand dermatitis among healthcare workers during the COVID-19 pandemic.

Methods

A quality improvement (QI) project was performed in a tertiary hospital using the Plan-Do-Study-Act model. Healthcare workers seen at the Occupational Dermatology Clinic from March 2020 to May 2021 for the first time for likely occupational irritant dermatitis were targeted for the project. Four workplace interventions were implemented: (a) substitute current alcohol-based hand rub (ABHR) with a different, gentler ABHR, (b) alternate ABHR with gentle hand wash products, (c) temporary job modification with less clinical work (d) switch latex gloves to nitrile gloves. The improvement was assessed after 2 months of workplace intervention using a visual analogue scale, based on changes seen on photographs taken at the baseline and monthly review. The target improvement was set at 70% after 2 months of workplace interventions.

Results

A total of 21 participants were included in the QI project. All participants were found to have significant improvement in their hand condition. The estimated mean reduction of signs and symptoms was 80% in comparison to their baseline hand condition before intervention.

Conclusion

Workplace interventions such as substituting irritant hand hygiene products with gentler alternatives and temporary reduction in clinical duties may be useful in improving the recovery rate of irritant hand dermatitis among healthcare workers. Areas with high hand hygiene workload or high incidences of hand dermatitis may opt to implement systemic workplace changes.
mHealth Applications to Monitor Lifestyle Behaviors and Circadian Rhythm in Clinical Settings: Current Perspective and Future Directions
Authors: Rosa Iolanda , Lages Marlene , Grilo Carlos , Barros Renata , Guarino Maria P.
Published: July 2022

Metabolic diseases are a global rising health burden, mainly due to the deleterious interaction of current lifestyles with the underlying biology of these diseases. Daily habits and behaviors, such as diet, sleep, and physical exercise impact the whole-body circadian system through the synchronization of the peripheral body clocks that contribute to metabolic homeostasis. The disruption of this system may promote the development of metabolic diseases, including obesity and diabetes, emphasizing the importance of assessing and monitoring variables that affect circadian rhythms. Advances in technology are generating innovative resources and tools for health care management and patient monitoring, particularly important for chronic conditions. The use of mobile health technologies, known as mHealth, is increasing and these approaches are contributing to aiding both patients and healthcare professionals in disease management and education. The mHealth solutions allow continuous monitoring of patients, sharing relevant information and data with physicians and other healthcare professionals and accessing education resources to support informed decisions. Thus, if properly used, these tools empower patients and help them to adopt healthier lifestyles. This article aims to give an overview of the influence of circadian rhythms disruption and lifestyle habits in the progression of metabolic diseases while also reviewing some of the mobile applications available to monitor lifestyle behaviors and individual chronobiology. Herein is also described the design and development of the NutriClock system, an mHealth solution developed by our team to monitor these variables.
Health Professionals' Knowledge, Attitude and Practices Regarding COVID-19 in Dessie City, Northeast Ethiopia: A Facility-Based Cross-Sectional Study
Authors: Alemu Tefera , Legesse Seid , Abera Abtew , Amare Semagn , Maru Minwuyelet , Shiferaw Birtukan , Missaye Assefa , Derseh Getaneh
Published: July 2022

Background

Knowledge and attitudes are among the key drivers of social behavioral change. We assessed employed health professionals' (HPs) knowledge, attitude, and practice regarding COVID-19 in Dessie city, northeast Ethiopia.

Methods

A facility-based cross-sectional study was conducted among 419 HPs working at Dessie city from 17 to 21 May 2020. The data were collected using a self-administered structured questionnaire. Knowledge, attitude, and practice are measured using 19, 16, and 8 questions, respectively. Knowledge and attitude scores are dichotomized at the 3rd quartile, while practice is using the mean value. Data entry and analysis were conducted using EpiData Manager 4.2 and SPSS 25, respectively. Three independent logistic regression analyses were carried out to determine the associated factors. We defined significant association at a p-value of < 0.05.

Results

Out of 419 participants, 369 (88.1%) have sufficient knowledge regarding COVID-19 (95% CI: 85–91). The mean knowledge score is 16.8 with a ± 2.1 SD. Similarly, 355 (84.7%) of the HPs have a favorable attitude toward COVID-19 (95% CI: 81–87.9). The mean attitude score is 14 with ± 2.1 SD. However, practice regarding COVID-19 is adequate only in 69.7% (292) of the HPs (95% CI: 65.2–94). The mean practice score is 5.1 with a ± 1.3 SD. Sufficient knowledge is significantly associated with the type of health facility (AOR: 4.4, 95% CI: 1.4–13.3), degree and above education (AOR: 2.6, 95% Cl: 1.4–4.9), radio availability (AOR: 2.4, 95% CI: 1.3–4.7), and social media utilization (AOR: 2.3, 95% CI: 1.1–5.1). The predictors of favorable attitude are training (AOR: 3.1, 95% CI: 1.6–6.1), sufficient knowledge (AOR: 5.2, 95% Cl: 2.6–10.4), and type of health facility (AOR: 2.3, 95% CI: 1.1–5.2).

Conclusion

Most HPs have sufficient knowledge and a favorable attitude regarding COVID-19. However, practice is relatively low and there remains plenty to build assertive preventive behaviors. The gap between knowledge and practice should be narrowed through an appropriate social and behavioral change communication strategy.
Optimizing the Practice Environment for Medical Staff in the Post-pandemic Era: A Discrete Choice Experiment
Authors: Wu Peilin , Li Zhenjing , Guo Wei , Wang Li , Chang Xiangxiang , Zhang Yanqun , Wang Li , Wang Lidan , Liu Qunying
Published: July 2022

Objective

This study aimed to elicit the stated job preferences of Chinese medical staff in the post-pandemic era and identify the relative importance of different factors in the practice environment.

Methods

We used an online discrete choice experiment (DCE) survey instrument to elicit the job preferences of medical staff (doctors and nurses) in tertiary hospitals in Anhui, China. Attributes and levels were generated using qualitative methods, and four attributes were considered: career development, workload, respect from society, and monthly income. A set of profiles was created using a D-efficient design. The data were analyzed considering potential preference heterogeneity, using the conditional logit model and the latent class logit (LCL) model.

Results

A total of 789 valid questionnaires were included in the analysis, with an effective response rate of 73.33%. Career development, workload, respect from society, and monthly income were significant factors that influenced job preferences. Three classes were identified based on the LCL model, and preference heterogeneity among different medical staff was demonstrated. Class 1 (16.17%) and Class 2 (43.51%) valued respect from society most, whereas Class 3 (40.32%) prioritized monthly income. We found that when respect from society was raised to a satisfactory level (50–75% positive reviews), the probability of medical staff choosing a certain job increased by 69.9%.

Conclusion

Respect from society was the most preferred attribute, while workload, monthly income, and career development were all key factors in the medical staff's job choices. The heterogeneity of the medical professionals' preferences shows that effective policy interventions should be customized to accommodate these drive preferences.
Global Trends in Nursing-Related Research on COVID-19: A Bibliometric Analysis
Authors: Zhang Qian , Li Shenmei , Liu Jing , Chen Jia
Published: July 2022

Background

Coronavirus disease 2019 (COVID-19) has significantly impacted healthcare, especially the nursing field. This study aims to explore the current status and hot topics of nursing-related research on COVID-19 using bibliometric analysis.

Methods

Between 2019 and 2022, publications regarding nursing and COVID-19 were retrieved from the Web of Science core collection. We conducted an advanced search using the following search query string: TS = (“Novel coronavirus 2019” or “Coronavirus disease 2019” or “COVID 19” or “2019-nCOV” or “SARS-CoV-2” or “coronavirus-2”) and TS = (“nursing” or “nurse” or “nursing-care” or “midwife”). Bibliometric parameters were extracted, and Microsoft Excel 2010 and VOSviewer were utilized to identify the largest contributors, including prolific authors, institutions, countries, and journals. VOSviewer and CiteSpace were used to analyze the knowledge network, collaborative maps, hotspots, and trends in this field.

Results

A total of 5,267 papers were published between 2020 and 2022. The findings are as follows: the USA, China, and the UK are the top three prolific countries; the University of Toronto, the Harvard Medical School, the Johns Hopkins University, and the Huazhong University of Science & Technology are the top four most productive institutions; Gravenstein, Stefan, and White, Elizabeth M. from Brown University (USA) are the most prolific authors; The International Journal of Environmental Research and Public Health is the most productive journal; “COVID-19,” “SARS-CoV-2,” “nurse,” “mental health,” “nursing home,” “nursing education,” “telemedicine,” “vaccine-related issues” are the central topics in the past 2 years.

Conclusion

Nursing-related research on COVID-19 has gained considerable attention worldwide. In 2020, the major hot topics included “SARS-CoV-2,” “knowledge,” “information teaching,” “mental health,” “psychological problems,” and “nursing home.” In 2021 and 2022, researchers were also interested in topics such as “nursing students,” “telemedicine,” and “vaccine-related issues,” which require further investigation.
Mapping the Swiss Vaccine Supply Chain
Authors: Thakur-Weigold Bublu , Buerki Pascal , Frei Patrice , Wagner Stephan M.
Published: July 2022

Objectives

The design of the supply chain determines how effectively any vaccination campaign can be operated. This case study of Switzerland's vaccine supply chain compares its design with public health objectives. It maps the vaccine supply chain in Switzerland as it was set up to handle the first shipments of Covid-19 vaccine in 2021 to enable a more holistic view of supply and demand flows. Recommendations are made to improve emergency logistics of vaccines in the future.

Methods

Twenty-six semi-structured interviews with international and Swiss stake-holders were coded and analyzed to arrive at a description of planning and distribution processes. The vaccine supply chain network structure was mapped, linking upstream and downstream flows of material and information. The visualization of nodes and flows was combined with spatial information, including population data. The results are summarized in narrative form to support decision-makers across disciplines.

Results

Despite adequate vaccine supply, abundant local endowments and high investment in infrastructure, the 2021 design of Switzerland's vaccine supply chain reduced the potential reach of target populations. The segmentation of catchment populations, collaboration between administrative units and better use of information on geolocation and material flows could have improved the speed and reach of vaccinations during the emergency response phase. Three recommendations are made for supply chain structures to support higher vaccination rates in the future.

Conclusions

The visualization identifies design alternatives which could have improved vaccination rates under the prevailing conditions. A supply chain map provides public health officials with a shared view of the vaccine supply chain in order to better match supply with demand. The case study contributes to developed country studies. In order to improve public health outcomes in Switzerland, investments to secure supply, strong national endowments, and excellent infrastructure must be combined with optimized supply chain design.
Evaluation of Proton MR Spectroscopy for the Study of the Tongue Tissue in Healthy Subjects and Patients With Tongue Squamous Cell Carcinoma: Preliminary Findings
Authors: Boussida Salem , François Yvener , Heintz Adrien , Saidak Zuzana , Dakpé Stéphanie , Coutte Alexandre , Chauffert Bruno , Devauchelle Bernard , Galmiche Antoine , Testelin Sylvie , Goudot Patrick , Constans Jean-Marc
Published: July 2022

Purpose

To noninvasively assess spectroscopic and metabolic profiles of healthy tongue tissue and in an exploratory objective in nontreated and treated patients with tongue squamous cell carcinoma (SCC).

Methods

Fourteen healthy subjects (HSs), one patient with nontreated tongue SCC (NT-SCC), and two patients with treated tongue SCC (T-SCC) underwent MRI and single-voxel proton magnetic resonance spectroscopy (1H-MRS) evaluations (3 and 1.5T). Multi-echo-times 1H-MRS was performed at the medial superior part (MSP) and the anterior inferior part (AIP) of the tongue in HS, while 1H-MRS voxel was placed at the most aggressive part of the tumor for patients with tongue SCC. 1H-MRS data analysis yielded spectroscopic metabolite ratios quantified to total creatine.

Results

In HS, compared to MSP and AIP, 1H-MRS spectra revealed higher levels of creatine, a more prominent and well-identified trimethylamine-choline (TMA-Cho) peak. However, larger prominent lipid peaks were better differentiated in the tongue MSP. Compared to HS, patients with NT-SCC exhibited very high levels of lipids and relatively higher values of TMA-Cho peak. Interestingly, patients with T-SCC showed almost nonproliferation activity. However, high lipids levels were measured, although they were relatively lower than lipids levels measured in patients with NT-SCC.

Conclusion

The present study demonstrated the potential use of in-vivo1H-MRS to noninvasively assess spectroscopic and metabolic profiles of the healthy tongue tissue in a spatial location-dependent manner. Preliminary results revealed differences between HS and patients with tongue NT-SCC as well as tongue T-SCC, which should be confirmed with more patients. 1H-MRS could be included, in the future, in the arsenal of tools for treatment response evaluation and noninvasive monitoring of patients with tongue SCC.
Abdominal heterotopic pregnancy after in vitro fertilization and embryo transfer following bilateral salpingectomy: A case report and literature review
Authors: Liu Yifeng , Li Yu , Li Keting , Li Shuangdi
Published: July 2022

Background

Risk of heterotopic pregnancy following bilateral salpingectomy has increased considerably due to the widespread use of assisted reproductive technology. Poor understanding of this condition often causes delayed or missed diagnosis.

Objective

In this report, we describe the case of a 30-year-old pregnant woman with lower abdominal pain lasting for half a day and a history of bilateral salpingectomy. Two embryos had been transferred 21 days preceding her presentation.

Methods

Case report.

Results

Laparoscopic surgery revealed intraperitoneal hemorrhage and proper ovarian ligament pregnancy confirmed by histopathology. Viable intrauterine pregnancy was verified 3 days later by ultrasound examination.

Conclusion

Heterotopic pregnancy is a serious condition that may be life-threatening. Clinicians should be aware of the potential for heterotopic pregnancy in patients receiving in vitro fertilization and embryo transfer after bilateral salpingectomy.
PSMA as a Target for Advanced Prostate Cancer: A Systematic Review
Authors: Belbina Safiya-Hana , Schmolze Mia Rose , Gereta Sofia , Laviana Aaron A.
Published: July 2022

Objective

Prostate-specific membrane antigen (PSMA) is a cell-surface protein widely expressed on most prostate cancer cells that has rapidly emerging clinical utility in the realm of prostate cancer. This systematic review aims to evaluate the efficacy as well as cost-effectiveness of PSMA in the roles of diagnosis and treatment in prostate cancer management.

Background

The use of PSMA in the initial staging of patients, early detection of recurrence, and response monitoring are critical to improving prostate cancer treatment. We performed a systematic review of the role of Gallium-68 (68Ga)-PSMA in the initial detection of prostate cancer and detection of biochemical recurrence (BCR) as well as the role of Lutium-177 (177Lu)-PSMA in theranostics. We also investigated the cost-effectiveness of both ligands in comparison to the current standard of care.

Methods

In February 2022 we performed a systematic and comprehensive review of the existing literature. We identified and screened articles published from 1983 up to January 2022 through PubMed. Only 1 study was included prior to 2011. We included articles that investigated the efficacy or cost-effectiveness of PSMA in prostate cancer detection and therapy. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRSIMA) guidelines eligible articles were selected, and relevant information was extracted from the original articles.

Results

A total of 26 articles were included in the analysis of this systematic review. These studies were heterogeneous and were comprised of five prospective studies including 336 patients, three retrospective analyses including 540 patients, one phase III trial, one survival analysis, one randomized control trial, three systematic reviews, three meta-analyses, two in-vivo studies, three reviews, and four cost analyses.

Conclusion

The diagnostic and therapeutic role of PSMA appears more efficacious and potentially less expensive than the standard treatment for patients with BCR of prostate cancer. Current evidence suggests PSMA will also fill an unmet need in initial diagnostics of prostate cancer and ligand therapy. However, a consensus has not yet been reached on cost-effectiveness of PSMA and further prospective studies are needed.
Abdomen anatomic characteristics on CT scans as predictive markers for short-term complications following radical resection of colorectal cancer
Authors: Zhang Xiao , Yang Zhengyang , Meng Cong , Gao Jiale , Liu Yishan , Shi Bohao , Sun Liting , Wu Guocong , Yao Hongwei , Zhang Zhongtao
Published: July 2022

Background

Prediction and management of short-term postoperative complications in patients with colorectal cancer are essential in postoperative rehabilitation. Through CT scan images, we can easily measure some parameters of abdomen anatomic characteristics. This study aimed to assess whether there is a relationship between the abdomen anatomic characteristics and short-term postoperative complications.

Materials and methods

We conducted a retrospective study. Eighty patients in each complication group and non-complication group were recruited with propensity score match. Demographics, perioperative laboratory results and surgical information were collected and compared between groups with univariate analysis. Significant elements were brought into subsequent logistic regression analysis and ROC analysis for further identification.

Results

Univariate analysis showed that preoperative white blood cells, preoperative neutrophil counts, rectus abdominis thickness (RAT), subcutaneous fat thickness (SFT), and abdomen depth (AD) were significantly different between the complication group and non-complication group. Logistic regression analysis demonstrated that higher RAT (p = 0.002), SFT (p < 0.001) and AD (p < 0.001) independently predicted the incidence of short-term postoperative complications.

Conclusions

In this study on patients undergoing radical resection of colorectal cancer, abdomen anatomic characteristics including higher RAT, SFT and AD are associated with an increased risk of short-term postoperative complications.
In Vitro–In Vivo Extrapolation by Physiologically Based Kinetic Modeling: Experience With Three Case Studies and Lessons Learned
Authors: Algharably Engi Abdelhady , Di Consiglio Emma , Testai Emanuela , Pistollato Francesca , Mielke Hans , Gundert-Remy Ursula
Published: July 2022

Physiologically based kinetic (PBK) modeling has been increasingly used since the beginning of the 21st century to support dose selection to be used in preclinical and clinical safety studies in the pharmaceutical sector. For chemical safety assessment, the use of PBK has also found interest, however, to a smaller extent, although an internationally agreed document was published already in 2010 (IPCS/WHO), but at that time, PBK modeling was based mostly on in vivo data as the example in the IPCS/WHO document indicates. Recently, the OECD has published a guidance document which set standards on how to characterize, validate, and report PBK models for regulatory purposes. In the past few years, we gained experience on using in vitro data for performing quantitative in vitro–in vivo extrapolation (QIVIVE), in which biokinetic data play a crucial role to obtain a realistic estimation of human exposure. In addition, pharmaco-/toxicodynamic aspects have been introduced into the approach. Here, three examples with different drugs/chemicals are described, in which different approaches have been applied. The lessons we learned from the exercise are as follows: 1) in vitro conditions should be considered and compared to the in vivo situation, particularly for protein binding; 2) in vitro inhibition of metabolizing enzymes by the formed metabolites should be taken into consideration; and 3) it is important to extrapolate from the in vitro measured intracellular concentration and not from the nominal concentration to the tissue/organ concentration to come up with an appropriate QIVIVE for the relevant adverse effects.
Evaluation of Brucellosis Vaccines: A Comprehensive Review
Authors: Heidary Mohsen , Dashtbin Shirin , Ghanavati Roya , Mahdizade Ari Marzie , Bostanghadiri Narjess , Darbandi Atieh , Navidifar Tahereh , Talebi Malihe
Published: July 2022

Brucellosis is a bacterial zoonosis caused by Brucella spp. which can lead to heavy economic losses and severe human diseases. Thus, controlling brucellosis is very important. Due to humans easily gaining brucellosis from animals, animal brucellosis control programs can help the eradication of human brucellosis. There are two popular vaccines against animal brucellosis. Live attenuated Brucella abortus strain 19 (S19 vaccine) is the first effective and most extensively used vaccine for the prevention of brucellosis in cattle. Live attenuated Brucella melitensis strain Rev.1 (Rev.1 vaccine) is the most effective vaccine against caprine and ovine brucellosis. Although these two vaccines provide good immunity for animals against brucellosis, the expense of persistent serological responses is one of the main problems of both vaccines. The advantages and limitations of Brucella vaccines, especially new vaccine candidates, have been less studied. In addition, there is an urgent need for new strategies to control and eradicate this disease. Therefore, this narrative review aims to present an updated overview of the available different types of brucellosis vaccines.
Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat
Authors: Alonso Flavio H. , Niedringhaus Kevin D. , Ceregatti Mariah G. , Maglaty Marisa A.
Published: July 2022

This case report describes for the first time the cytologic characteristics of a hormonally secreting pituitary adenoma in a cat. An 8-year-old female spayed domestic long-haired cat was referred with a previous diagnosis of hypersomatotropism and secondary diabetes mellitus 7 months prior. Clinical signs included weight loss, polyphagia, polyuria, and polydipsia. Serum insulin-like growth factor-1 was 340 nmol/L (RI: 12-92), and CT scan revealed a hypophyseal mass, and a presumptive diagnosis of acromegaly was made. A transsphenoidal hypophysectomy was performed. A fragment of the pituitary gland was subjected to a squash preparation and cytology revealed a neuroendocrine neoplasm characterized by anisokaryosis and prominent nucleoli. Additional cytologic findings included cell cohesiveness, indistinct cytoplasmic borders, nuclear crowding, molding, and fragmentation. A diagnosis of adenoma was based on a lack of histopathologic or imaging evidence of invasion. A week later, during post-surgical hospitalization, the patient worsened and died. Histopathology from a necropsy procedure revealed fibrinosuppurative meningitis as a post-surgical complication. Pituitary adenomas might have an aggressive cytologic appearance, despite a lack of histopathologic invasion or dissemination.
Effects of Dietary Protein and Energy Levels on Growth Performance, Nutrient Digestibility, and Serum Biochemical Parameters of Growing Male Mink (Neovison vison)
Authors: Han Feifei , Wang Jing , Chen Lihong , Zhong Wei
Published: July 2022

The objective of this experiment was to determine the optimum dietary metabolic energy (ME) and crude protein (CP) levels of growing male mink. One hundred forty-four healthy male minks at 75 days were randomly allocated into the six groups with 24 replicates, which was one mink for each replicate. The mink were fed six experimental diets with two CP levels (31.59 and 35.63%) and three ME levels (14.17, 15.96, and 17.73 MJ/kg) for a 7-day preliminary period and then for an 88-day experimental period. The final body weight (BW), average daily gain (ADG), feed conversion ratio (FCR), fat digestibility, energy intake, the concentration of glucose (GLU), and low-density lipoprotein (LDL) of the mink were significantly increased by the CP or ME levels (P < 0.05). In addition, CP levels significantly (P < 0.01) increased the N intake and N retention. Dietary ME levels increased the utilization of gross energy. Obviously, there were significant CP × ME interactions for the final BW, ADG, fat digestibility, energy utilization, GLU, LDL (P < 0.01), and triglyceride contents (P < 0.05). Therefore, the optimum CP and ME levels were 35.97% and 18.18 MJ/kg, which can improve growth, enhance nutrient digestion, and promote blood lipid metabolism in growing mink.
New Trends in Mining Equipment Design
Authors: András József , Kovács József , András Endre
Published: July 2022

Mining machinery and equipment have changed little in recent decades, from the point of view of the principle of operation, construction and structure. But in terms of dimensions, performance and stresses they have made a lot of progress, experiencing unprecedented sophistication and complexity. In order to fulfil the new requirements imposed by the increasing productivity and efficiency demands, as well as the economic, environmental and safety constraints, their design and development must comply with the general advance of overall technology. Therefore, recently, modern analytical methods have also been included in the design and development of mining machines. Among other issues, the present paper examines the theoretical and conceptual aspects related to the mining machinery’ design requirements involving mechatronics.
Interpretation of Road Traffic Noise Changes with Noise Mapping
Authors: Hajnal Petra , Kocsis Dénes László
Published: July 2022

With the advancement of technology and the drastic increase in the number of noise sources, environmental noise emission is increasing year by year. In the case of urban dwellers, noise from road traffic accounts for the largest share of noise pollution, with a number of negative health effects. The aim of our research is to monitor the road noise emission of the city of Debrecen in detail, using hourly traffic data. After data processing, various situations were modeled according to the MSZ 15036:2002 standard with the help of the IMMI noise mapping program. Overall, it can be said that the studies we have carried out support the high level and increasing trend of noise exposure.
Impact Energy Absorbtion by Active Braking
Authors: Kertész József , Kovács Tünde Anna
Published: July 2022

Due to urbanization and the significantly increasing number of vehicles, urban roads are becoming more congested day by day, with the result that the rear-end collision has become the third most common type of collision. By developing and integrating active and passive safety systems, car manufacturers are working to prevent accidents and reduce the consequences of an accident. The present study examines a braking procedure and its applicability based on the integration of a passive and active safety system and provides development guidelines for the reduction of personal injuries and property damage in the event of a rear-end accident.
Partial Examination of the Design of the Bombed Olt Bridge in Sâncrăieni
Authors: Kisfaludi-Bak Zsombor , Gobesz F.-Zsongor
Published: July 2022

Throughout Transylvania, the ruins or remains of many engineering structures and buildings can be observed, and this allows us to draw a lot of interesting conclusions. This research seeks to shed some light on the design process of older bridges in Transylvania through a case study. Hydraulic calculations based on field measurements show the hydraulic requirements used in the original design of the bridge. The obtained data was compared to the current requirements of the Romanian design standards.
Study of the Effect of Soil Volumetric Weight on the Energy Requirement for a Spading Machine by Simulation
Authors: Pásztor Judit , Tolvaly-Roşca Ferenc , Forgó Zoltán
Published: July 2022

In this paper, we simulate the operation of a spading machine on three soil types; easy to work, medium to work and heavy, using a previously validated SimuLink model of an MSS-1.40M spading machine. We determine the forces during spading. We explore the physical and mechanical properties of the soil that play a role in the spading process. By simulation of the spading process with the MSS-1.40M spading machine, we determine the torque on the drive shaft and the required mechanical work on the three soil types.
Reduction of Retained Austenite in Tool Steels
Authors: Tóth László
Published: July 2022

Tools are devices for machining materials which must have different properties depending on their intended application. These properties are determined by the chemical composition and microstructure of the tool steel. The desired steel microstructure can be achieved with suitable heat treatment technology. During this heat treatment, the microstructure of the tool steel may develop various lattice structural transformations which in turn can cause internal stresses, cracks and distortions. One possible reason for these undesirable results may be the retained austenite. These effects are most pronounced in tool steels. In this study, the possibilities for reducing the amount of residual austenite during the heat treatment of tool steel is investigated.
Shape Optimisation of Assembled Plate Structures with the Boundary Element Method
Authors: Morse Llewellyn , Mallardo Vincenzo , Sharif-Khodaei Zahra , Aliabadi Ferri M.H.
Published: July 2022

A novel methodology is presented for performing sensitivity analyses of assembled plate structures using the Boundary Element Method (BEM). The main novelty of this work is that the exact implicit derivatives of the BEM formulations for assembled plate structures have been derived for the first time and incorporated into a newly developed Implicit Differentiation Method (IDM), enabling sensitivity analyses to be conducted for more complex and realistic structures in a more accurate, robust, and efficient manner than previous approaches. Three numerical examples are investigated to validate the derived exact implicit derivatives and to demonstrate how they could be used for a potential application involving the shape optimisation of a complex X-core structure from the canard of a Eurofighter Typhoon fighter jet. Results show that the newly developed IDM is more accurate, robust, and efficient when compared to alternative methodologies using derivatives obtained from methods such as the Finite Difference Method (FDM) and the Finite Element Method (FEM).
Parametric Optimisation Analysis of Micro/Nano-Satellite Flywheels Based on the NSGA-Ⅱ Optimisation Algorithm
Authors: Jiang Wei , Xie Weicheng , Sun Shuai
Published: July 2022

As the key mechanism of attitude control of micro/nano-satellites, the flywheel design is mostly based on empirical formulae that do not meet the requirements of lightweight and high-performance micro/nano-satellite platforms. In this paper, the structural shape of micro/nano-satellite flywheels is analysed, and a set of flywheel optimisation methods is proposed to realise the parametric optimisation analysis of the structural shape. First, the general principle of flywheel efficiency is introduced, the optimisation evaluation factor of flywheel design is proposed, and the parametric model of a flywheel structure is established by using the finite element secondary development technology, which can be used to quickly build a finite element model of different dimensions. Second, the optimisation model of flywheels is established while introducing the approximate model algorithm, greatly improving the optimisation efficiency. Considering the phenomenon that the genetic algorithm falls below local optimisation under a large parameter range, the method of initial optimisation is proposed to reduce the upper and lower limits of the optimisation parameters. Finally, the optimal shape of the flywheel is obtained by using the parametric optimisation model of the flywheel. The finite element analysis results show that the flywheel optimisation evaluation factor proposed in this work can effectively improve the comprehensive performance of the flywheel as the optimisation target, and the corresponding optimisation method can be well applied to the engineering application and design of micro/nano-satellite platforms. This can help guide the structural optimisation design of micro/nano-satellite platforms in the future.
Therapeutic Potential of Intrabodies for Cancer Immunotherapy: Current Status and Future Directions
Authors: Böldicke Thomas
Published: July 2022

Tumor cells are characterized by overexpressed tumor-associated antigens or mutated neoantigens, which are expressed on the cell surface or intracellularly. One strategy of cancer immunotherapy is to target cell-surface-expressed tumor-associated antigens (TAAs) with therapeutic antibodies. For targeting TAAs or neoantigens, adoptive T-cell therapies with activated autologous T cells from cancer patients transduced with novel recombinant TCRs or chimeric antigen receptors have been successfully applied. Many TAAs and most neoantigens are expressed in the cytoplasm or nucleus of tumor cells. As alternative to adoptive T-cell therapy, the mRNA of intracellular tumor antigens can be depleted by RNAi, the corresponding genes or proteins deleted by CRISPR-Cas or inactivated by kinase inhibitors or by intrabodies, respectively. Intrabodies are suitable to knockdown TAAs and neoantigens without off-target effects. RNA sequencing and proteome analysis of single tumor cells combined with computational methods is bringing forward the identification of new neoantigens for the selection of anti-cancer intrabodies, which can be easily performed using phage display antibody repertoires. For specifically delivering intrabodies into tumor cells, the usage of new capsid-modified adeno-associated viruses and lipid nanoparticles coupled with specific ligands to cell surface receptors can be used and might bring cancer intrabodies into the clinic.
Adenophora Stricta Root Extract Protects Lung Injury from Exposure to Particulate Matter 2.5 in Mice
Authors: Park Seok-Man , Jung Cheol-Jong , Lee Dae-Geon , Choi Beom-Rak , Ku Tae-Hun , La Im-Joung , Cho Il-Je , Ku Sae-Kwang
Published: July 2022

Chronic exposure of particulate matter of less than 2.5 μm (PM2.5) has been considered as one of the major etiologies for various respiratory diseases. Adenophora stricta Miq. is a medicinal herb that has been used for treating respiratory diseases in East Asia. The present study investigated the effect of A. stricta root extract (AsE) on PM2.5-induced lung injury in mice. Oral administration of 100–400 mg/kg AsE for 10 days significantly reduced the PM2.5-mediated increase in relative lung weight, but there was no difference in body weight with AsE administration. In addition, AsE dose-dependently decreased congested region of the lung tissue, prevented apoptosis and matrix degradation, and alleviated mucus stasis induced by PM2.5. Moreover, cytological analysis of bronchioalveolar lavage fluid revealed that AsE significantly inhibited the infiltration of immune cells into the lungs. Consistently, AsE also decreased expression of proinflammatory cytokines and chemokines in lung tissue. Furthermore, AsE administration blocked reactive oxygen species production and lipid peroxidation through attenuating the PM2.5-dependent reduction of antioxidant defense system in the lungs. Therefore, A. stricta root would be a promising candidate for protecting lung tissue from air pollution such as PM2.5.
An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications
Authors: Kurt-Celep Inci , Zheleva-Dimitrova Dimitrina , Gevrenova Reneta , Uba Abdullahi Ibrahim , Zengin Gokhan , Yıldıztugay Evren , Picot-Allain Carene Marie Nancy , Lorenzo José Manuel , Mahomoodally Mohamad Fawzi , Montesano Domenico
Published: July 2022

The biological activity of the aerial part and rhizomes of Primula auriculata were assessed for the first time. The biological activities (antioxidant properties, enzyme inhibition, and AGE inhibition) as well as the phenolic and flavonoid contents of the ethyl acetate, ethanol, hydro-ethanol and water extracts of P. auriculata aerial parts and rhizomes were determined. Cell viability assays and gelatin zymography were also performed for MMP-2/-9 to determine the molecular mechanisms of action. The gene expression for MMPs was described with RT-PCR. The levels of various proteins, including phospho-Nf-κB, BCL-2, BAX, p-53, and cyclin D1 as well as RAGE were measured using Western blot analysis. The hydro-ethanol extract of the aerial part possessed the highest phenolic (56.81 mg GAE/g) and flavonoid (63.92 mg RE/g) contents. In-depth profiling of the specialized metabolites by ultra-high-performance liquid chromatography—high-resolution mass spectrometry (UHPLC-HRMS) allowed for the identification and annotation of 65 compounds, including phenolic acids and glycosides, flavones, flavonols, chalcones, dihydrochalcones, and saponins. The hydro-ethanol extract of the aerial parts (132.65, 180.87, 172.46, and 108.37 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) and the ethanol extract of the rhizomes (415.06, 638.30, 477.77, and 301.02 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) exhibited the highest free radical scavenging and reducing activities. The ethanol and hydro-ethanol extracts of both the P. auriculata aerial part and rhizomes exhibited higher inhibitory activity against acetylcholinesterase, while the hydro-ethanol extracts (1.16 mmol ACAE/g, for both the aerial part and rhizomes extracts) were more active in the inhibition of α-glucosidase. After the treatment of an HT-29 colorectal cancer cell line with the extracts, the apoptosis mechanism was initiated, the integrity of the ECM was remodeled, and cell proliferation was also taken under control. In this way, Primula extracts were shown to be potential drug sources in the treatment of colorectal cancer. They were also detected as natural MMP inhibitors. The findings presented in the present study appraise the bioactivity of P. auriculata, an understudied species. Additional assessment is required to evaluate the cytotoxicity of P. auriculata as well as its activity in ex vivo systems.
Optimal Design of Fluid Flow and Heat Transfer in Pipe Jackets Having Bow Cross-Sections
Authors: Li Weicong , Yin Xia , Li Huifang , Qian Caifu , Wu Zhiwei
Published: July 2022

Pipe jackets are widely used in engineering as a component for heating or cooling reactors or other equipment. In this paper, fluid flow and heat transfer performances in straight or helical pipes having bow cross-sections with the central angle α in the range of 90–180° were numerically simulated using water as the medium under turbulent flow conditions. The results show that, under the same volume flow rate, the bow cross-sectional pipe with α less than 180° can enhance heat transfer and shows better comprehensive heat transfer performance compared with the half-pipe with α being 180°. As a result, less heat exchange surface (or the weight) of the bow cross-sectional pipe is needed for transferring the same amount of heat. Specifically, for the helical pipe having the bow cross-section with α being 90°, the weight of the pipe can be reduced by about 80%. In order to facilitate the engineering design of bow cross-sectional pipe jackets, correlation formulas for Nu and f of the whole straight pipe and the helical pipe were modified to include the influence of the central angle α of the bow cross-sections.
The Effect of Mesenchymal Stem Cells, Adipose Tissue Derived Stem Cells, and Cellular Stromal Vascular Fraction on the Repair of Acute Anal Sphincter Injury in Rats
Authors: Chen Wenbin , He Zijian , Li Shuyu , Wu Zixin , Tan Jin , Yang Weifeng , Li Guanwei , Pan Xiaoting , Liu Yuying , Lyu Feng-Juan , Li Wanglin
Published: July 2022

Background: Anal sphincter incontinence (ASI) can cause a serious decline in the quality of life and can cause a socioeconomic burden. Studies have shown that bone marrow mesenchymal stem cells (MSC) have significant therapeutic effects on ASI, but the cost and risk of MSC harvest limit their further application. In contrast, adipose tissue derived stem cells (ADSC) and cellular stromal vascular fraction (CSVF) as stem cell sources have multipotency and the advantage of easy harvest. Objective: Here we aim to investigate the effects of ADSC and CSVF on treating ASI and compare them to that of bone marrow MSC. Methods: Bone marrow MSC, ADSC, and CSVF were obtained and labeled with green fluorescent protein (GFP), and CSVF was labeled with DIL. Sprague Dawley (SD) rats were divided into 5 groups. Four groups were injected with 0.2 mL phosphate buffer saline (PBS), 1 × 107/0.2 mL of MSC, ADSC, or CSVF, respectively, after model establishment. The control group received no treatment. The repair was assessed by anal functional tests and immunostaining on day 5 and day 10 after injection. Results: MSC, ADSC, and CSVF significantly promoted tissue repair and the recovery of muscle contraction and electromyographic activity in ASI. The generation of myosatellite cells by injected MSC, ADSC, and CSVF was found in the wounded area. On day 5, CSVF showed highest therapeutic effect, while on day 10, MSC and ADSC showed higher therapeutic effects than CSVF. When comparing the effects of MSC and ADSC, ADSC was slightly better than MSC in the indexes of anal pressure, etc. Conclusion: ADSC and CVSF are alternative stem cell sources for ASI repair.