bluuebunny/crossref_metadata_2025 huggingface dataset:
Carbapenems Resistant Nocardia ?! - A Case Report
Authors: Ivan Vlad Sabin , Ciubotaru Paul Gabriel , Cirin Liviu , Giru Florin , Lighezan Daniel Florin , Buzaș Roxana
Published: September 2024

Nocardia is an emerging bacterial disease that often affects patients with compromised immune systems. As survival increases, more and more patients are receiving solid organ transplantations, and more patients are cancer survivors and receiving long-term immune system modifying agents or corticotherapy and immunosuppressive agents, organisms that are not harmful in usual circumstances become a public health problem.
Carbapenems are usually a second-line therapy in the setting of Nocardia infections. We present the case of a patient who had an immunocompromised status and was diagnosed with Nocardia farcinica, which showed in vitro resistance to carbapenems. The symptoms were non-specific and had a common presentation, although the infection was disseminated and had severe CNS and ocular involvement.
The clinical course was more severe when the carbapenem was withdrawn based on the provided antibiogram and markedly improved when clinical judgment considered it might be beneficial.
The first case in our region to describe an „in vitro” carbapenem-resistant Nocardia species, that responded „in vivo” differently and we believe it is important to remind clinicians of this potentially severe disease in difficult cases.
Dietary Vitamin D Intake in Premenopausal Moroccan Women: Food Sources, Socio-Demographic Determinants and Correlation with 25-Hydroxyvitamin D Levels
Authors: Zouine Noura , Lhilali Ilham , Godderis Lode , El Midaoui Adil , El Jaafari Samir , Zegzouti Filali Younes
Published: September 2024

Background/Objectives: Women's reproductive and overall well-being are intricately associated to vitamin D levels. In Morocco, vitamin D deficiency is a major issue for premenopausal women, yet little data exists on their dietary intake of this nutrient. This study explores vitamin D dietary intake, socio-demographic determinants, and its correlation with serum 25-hydroxyvitamin D [25(OH)D3] in premenopausal Moroccan women. Methods: A cross-sectional study was conducted with 355 women aged 18-49 in Meknes, Morocco, using validated questionnaires to assess dietary intake and sun exposure. Potential covariates such as physical activity and BMI were also assessed . Serum 25(OH)D was measured via chemiluminescence immunoassay. Chi-square tests and Spearman correlation were used to identify socio-demographic factors influencing vitamin D intake. Linear and multivariate regression analysis determined the main predictors of serum 25(OH)D levels. Results :The median (interquartile range) vitamin D dietary intake was 2.8 (2.7) µg/day , with less than 20% of women meeting the recommended 5 µg/day. Major dietary sources were fish (48%), dairy (24.3%), and meat (9.4%), with fortified foods contributing only for 7%. Lower intake was linked to younger age (p=0.004) and rural living (p=0.024). While no significant association was found between dietary intake and serum 25(OH)D ((β(SE): 0.155(0.094), p=0.340 ) , sun exposure positively predicted serum levels(β(SE): 0.343 (0.128), p=0.008) , and BMI negatively affected them (β(SE): -1.128 (0.337), p=0.001). Conclusions: Our findings highlight insufficient vitamin D intake among premenopausal Moroccan women, especially younger and rural women. Nutritional interventions are needed to address this deficiency, promoting better dietary habits, sun exposure, and healthy weight.
Vocation of Human Care and Soft Skills in Nursing and Physiotherapy Students. A Cross-Sectional Study
Authors: Hernández-Xumet Juan-Elicio , García-Hernández Alfonso-Miguel , Fernández-González Jerónimo-Pedro , Marrero-González Cristo-Manuel
Published: September 2024

Background: Empathy and assertiveness are two essential soft skills for health professionals such as nurses or physiotherapists. Both professions are characterised by their contribution to preserving and improving health and human care, and for their vocation of service. One of the achievements of the training is the voluntary, conscious, and individually inspired career choice; Objetives: This study aimed to evaluate the empathy, assertiveness, and care vocational levels among undergraduate students enrolled in the Nursing and Physiotherapy Degree programmes and to investigate the relationship between these soft skills and the care vocation; Methods: A cross-sectional study of nursing and physiotherapy students was conducted in the 2022/2023 academic year. The Interpersonal Reactivity Index scales for empathy, the Rathus test for assertiveness, and the “Vocation of Service for Human Care” questionnaire were used as study tools. Finally, 226 students participated in the study; Results: The empathy, assertiveness and vocation of service for human care of the students was found to be acceptable. Significant differences were also observed according to the gender variable or career in the students, with female students presenting better results in empathy subscales or vocation (p < 0.05). Students who are working or have clinical experience in other professions score lower on the empathy personal distress subscale (p < 0.05); Conclusions: Both nursing and physiotherapy students demonstrate satisfactory levels of empathy, assertiveness and vocation for human care. However, gender and previous work experience do notably influence these scores. It would be beneficial to conduct long-term studies with educational interventions to train and develop empathy, assertiveness and vocation for human care.
Covariant Representation of Spin and Entanglement --- A Review and Reformulation
Authors: Land Martin
Published: September 2024

A consistent theory of quantum entanglement requires that constituent single-particle states belong to the same Hilbert space, the coherent eigenstates of a complete set of operators in a given representation, defined with respect to a shared continuous parameterization. Formulating such eigenstates for a single relativistic particle with spin, and applying them to the description of many-body states, presents well-known challenges. In this paper, we review the covariant theory of relativistic spin and entanglement in a framework first proposed by Stueckelberg and developed by Horwitz, Piron, et.\ al. This approach modifies Wigner's method by introducing an arbitrary timelike unit vector $n^\mu$ on which one induces a representation of $SL(2,C)$, rather than induce on the spacetime momentum $p^\mu$. Generalizing this approach, we construct relativistic spin states on an extended phase space $\{(x^\mu,p^\mu),(\zeta^\mu,\pi^\mu)\}$, inducing a representation on the momentum $\pi^\mu$, thus providing a novel dynamical interpretation of the timelike unit vector $n^\mu = \pi^\mu / M$. Studying the unitary representations of the Poincar\'e group on the extended phase space allows us to define basis quantities for quantum states and develop the gauge invariant electromagnetic Hamiltonian in classical and quantum mechanics. We write plane wave solutions for free particles and construct stable singlet states, and relate these to experiments involving temporal interference, analogous to the spatial interference known from double slit experiments.
Unlocking the Therapeutic Potential of Oxystelma esculentum: A Phytochemical Treasure Trove with Anticancer and Lactogenic Properties
Authors: Safdar Maryem , Ahmad Khalil , Khan Muhammad Younus , Sarwar Ghulam , Rao Muhammad Junaid , Abbas Aqleem , Shakeel Muhammad Taimoor , Batool Salma , Alrefaei Abdulwahed Fahad , Almutairi Mikhlid H.
Published: September 2024

This study investigates the phytochemical profile, cytotoxic effects, and lactogenic activity of Oxystelma esculentum, a plant renowned for its traditional medicinal uses. Preliminary phytochemical screening revealed a rich array of secondary metabolites, including alkaloids, flavonoids, glycosides, and tannins, predominantly in polar solvents such as methanol and ethanol. Spectroscopic analysis further identified key functional groups, suggesting significant bioactivity. The cytotoxic potential was evaluated against ovarian (OVCAR3), breast (T47D), and cervical (HeLa) cancer cell lines, demonstrating a concentration-dependent increase in cytotoxicity, with T47D cells exhibiting the highest sensitivity (IC50 = 42.82 μg/ml). Additionally, the brine shrimp lethality assay indicated low toxicity, while in vivo studies highlighted the extract's ability to enhance milk yield and pup growth in lactating rats, correlating with increased prolactin levels. These findings underscore Oxystelma esculentum as a promising candidate for natural anticancer therapies and lactation enhancement, warranting further exploration of its bioactive compounds and mechanisms of action.
Neurotoxicity Biochemical Biomarkers in Fish Toxicology
Authors: Witeska Malgorzata
Published: September 2024

Acetylcholinesterase (AChE) activity is the most commonly used neurotoxicity biomarker in fish. It is measured mostly in the brain but can also be evaluated in muscle or (in the case of very small fish) in whole body homogenate. AChE activity is measured using standard methods, thus the results obtained by various authors are comparable. AChE seems to be a sensitive neurotoxicity biomarker since in most cases of fish exposure to various toxic agents a decrease in the enzyme activity was observed. The effects of toxic agents on AChE activity are concentration and time-related. An increase in AChE activity occurred very rarely. The results of the analysis showed that most aquatic pollutants may modulate AChE activity. Acetylcholinesterase activity can be also used to evaluate transgenerational neurotoxic effects.
Design and Testing Acoustically Stimulated Anaerobic Digestion Coupled with Low Level Post Aeration for Agricultural Wastewater Remediation
Authors: Loughrin John H. , Silva Philip J. , Antle Stacy W. , Lovanh Nanh , Vanotti Matias B. , Sistani Karamat R.
Published: September 2024

The construction of an anaerobic digester coupled with post-digestion low level aeration for agricultural wastewater treatment is described. The digester employs underwater speakers to accelerate the anaerobic digestion process while retaining solids to reduce the strength of the effluent. The digester effluent is sent to a holding tank and fed at a low flow rate to an aeration tank to effect partial nitrification of the wastewater. The outlet of this tank is sent to a settling tank to retain biomass that developed in the aeration tank and the effluent is sent to a small, constructed wetland to further reduce wastewater nitrogen and phosphorus. The wetland was planted with the broadleaf cattail, Typha latifolia, and hence to a retention basin. The system has reduced energy consumption due to both the use of underwater sonic treatment and low-level aeration that is not designed to achieve full nitrification/denitrification but rather to achieve a mixture of ammonium, nitrite, and nitrate that might foster the development of a consortium of organisms (i.e. nitrifiers, Anammox bacteria) that can remediate wastewater ammonium at low cost. Biogas is sent to an inground condenser where different treatments may be tested to remove carbon dioxide and hydrogen sulfide. The system is meant to serve as a complex where various technologies and practices can be evaluated to improve the treatment of agricultural wastewater.
Comparative Study of Time Series Analysis Algorithms Suitable for Short-term Forecasting in Implementing Demand Response Based on AMI
Authors: Park Myung-joo , Yang Hyo-sik
Published: September 2024

This paper compares Demand Response algorithms suitable for Short-term Forecasting based on Advanced Metering Infrastructure (AMI). It selects ARIMA (AutoRegressive Integrated Moving Average), SARIMA (Seasonal ARIMA), LSTM (Long Short-Term Memory), and SVM (Support Vector Machine) as the primary research algorithms and delves into their theoretical foundations and functional characteristics. The theoretical background section explores each algorithm’s applicability in analyzing time-series data, recognizing nonlinear patterns, and solving optimization and classification problems. The methodology section will detail the methods of AMI data collection, the implementation of the algorithms, and the experimental setup. In the experiments and results section, the performance of each algorithm will be assessed by applying AMI data and presenting the outcomes of comparative analyses, with a focus on evaluating the predictive accuracy of the algorithms. The discussion will interpret the experimental results, analyzing the advantages and disadvantages of each algorithm and their applicability in the AMI system. It will also explore the limitations of the current research and directions for future research. The conclusion will summarize the key findings of the study and affirm how this research contributes to understanding and improving short-term forecasting and demand response systems based on AMI.
Fouling of Reverse Osmosis (RO) and Nanofiltration (NF) Membranes by Low Molecular Weight Organic Compounds (LMWOCs), Part 1: Fundamentals and Mechanism
Authors: Maeda Yasushi
Published: September 2024

Reverse osmosis (RO) and nanofiltration (NF) are ubiquitous technologies in modern water treatment, finding applications across various sectors. However, the availability of high-quality water suitable for RO/NF feed is diminishing due to droughts caused by global warming, increasing demand, and water pollution. As concerns grow over the depletion of precious freshwater resources, a global movement is gaining momentum to utilize previously overlooked or challenging water sources, collectively known as “marginal water.” Fouling is a serious concern when treating marginal water. In RO/NF, biofouling, organic and colloidal fouling, and scaling are particularly problematic. Of these, organic fouling, along with biofouling, has been considered difficult to manage. The major organic foulants studied are natural organic matter (NOM) for surface water and groundwater and effluent organic matter (EfOM) for municipal wastewater reuse. Polymeric substances such as sodium alginate, humic acid, and proteins have been used as model substances of EfOM. Fouling by low molecular weight organic compounds (LMWOCs) such as surfactants, phenolics, and plasticizers is known, but there have been few comprehensive reports. This review aims to shed light on fouling behavior by LMWOCs and its mechanism. LMWOC foulants reported so far are summarized, and the role of LMWOCs is also outlined for other polymeric membranes, e.g., UF, gas separation membranes, etc. Regarding the mechanism of fouling, it is explained that the fouling is caused by the strong interaction between LMWOC and the membrane, which causes the water permeation to be hindered by LMWOCs adsorbed on the membrane surface (surface fouling) and sorbed inside the membrane pores (internal fouling). Adsorption amounts and flow loss caused by the LMWOC fouling were well correlated with the octanol-water partition coefficient (log P). In part 2, countermeasures to solve this problem and applications using the LMWOCs will be outlined.
Comparison of Novel Hematological Biomarkers in Alopecia Areata and Other Not-Cicatricial Alopecia: A Retrospective Study
Authors: Di Cesare Antonella , Rosi Elia , Scandagli Ilaria , Prignano Francesca
Published: September 2024

Introduction & Objectives: Blood cells-(BC)count derived parameters have been inves-tigated in systemic inflammation, cancer, and various cutaneous diseases. Little is known about their usefulness in trichology, especially as prognostic and therapeutic biomarkers. We conducted a retrospective study on patients with not-cicatricial alopecia to assess differences in BC-count. Materials & Methods: Patients with alopecia areata (AA), telogen effluvium (TE), androgenic alopecia (AGA), psoriasis and hidradenitis suppurativa (HS) were included in the study. Baseline complete BC-count and derived parameters (i.e. NLR, PLR, MLR, SII; PIV) were recorded and analyzed for each patient and at different timepoints for AA patients on systemic agents. Results: 170 patients fulfilled inclusion criteria. BC-count and derived values were similar across the not-cicatricial alopecia groups, while general differences were observed compared to psoriasis and HS. TE displayed a closer inflammatory signature to psoriasis with respect to CRP, NLR, MLR, SII and PIV. We also found a significant reduction in RBCs in severe versus patchy-AA and an increase of SII in acute versus chronic AA. Modulation of platelet number and volume could be used as therapeutic marker in AA. Conclusions: In our experience, the BC-count and its derived parameters could represent potential tools in AA and TE.
Analysis of the Motion of a Robotic Arm for Fruit Harvesting Using Matlab Software
Authors: Salazar Maxwell , Portero Paola
Published: September 2024

This article presents a kinematic analysis of a 4-degree-of-freedom (DOF) robotic arm equipped with a 3-finger gripper, specifically designed for harvesting fruits of varying sizes. The kinematic modeling is thoroughly detailed, encompassing the equations of motion, homogeneous transformation matrices, and kinematic solutions required for the efficient operation of the robotic arm. This analysis is crucial for optimizing both the design and programming of agricultural robots, aiming to enhance harvesting efficiency and reduce labor costs. Additionally, an in-depth examination of the 3-finger gripper’s movement is provided, illustrating how MATLAB facilitates the simulation and visualization of its dynamic behavior during the opening and closing processes. The benefits of using MATLAB for this purpose are emphasized, including its ease of implementation, advanced simulation capabilities, and seamless integration with other tools to optimize the performance of robotic systems in agricultural settings. This study makes a valuable contribution to the field of agricultural robotics, offering technical insights that can be applied in the development of sophisticated robotic solutions for the modern agricultural industry.
Self-Perceived Health, Mood, and Substance Use Among Adolescents: An Analysis to Enhance Family, Community, and Mental Health Care
Authors: Zafra-Agea Jose Antonio , García-Salido Cristina , Ramirez-Baraldes Estella , Vilafranca-Cartagena Mireia , Colillas-Malet Ester , Portabella-Serra Anna , García-Gutiérrez Daniel
Published: September 2024

Adolescence is a critical period for the development of self-perception, emotional well-being, and health-related behaviors. During this stage, adolescents undergo significant physical, emotional, and social changes that influence their overall health and interactions with their environment. This study analyzes the prevalence of behaviors related to self-perceived health, mood, and substance use among adolescents, identifies risk factors, and draws comparisons between different groups. It also examines how these factors interact with family and community dynamics to inform strategies for improving mental health care. Method: A descriptive cross-sectional study using questionnaires was conducted. Participants were adolescents aged 14 to 18 years from a school in the Baix Llobregat province of Catalonia. Descriptive and bivariate statistical analyses were performed using the chi-square test and p-value calculations with R Project software. Frequency and percentage analyses were employed to describe the health behaviors and emotional states of the participants. Results: The study reveals significant variations in adolescents' self-perceived health, emotional management, and substance use patterns. Adolescents with lower self-perceived health and negative mood states tend to exhibit higher rates of substance use, particularly alcohol and tobacco. Gender differences were observed, with girls generally reporting better health awareness and emotional regulation compared to boys. Conclusions: This study highlights the need for integrated approaches to family, community, and mental health care. Findings emphasize the importance of early intervention programs addressing emotional well-being and substance use in a holistic manner. Public health policies should prioritize comprehensive strategies involving schools, families, and communities to foster healthier behaviors and improve adolescent mental health outcomes.
Glycated Haemoglobin (HbA1C) in Cardiac Surgery; A Narrative Review
Authors: Luthra Suvitesh , Viola Laura , Navaratnarajah Manoraj , Thirukumaran David , Velissaris Theodore
Published: September 2024

Perioperative dysglycemia in cardiac surgery is associated with poor outcomes. Glycemic variability rather than glucose levels are a predictor of length of ICU stay, rise in creatinine and acute kidney injury after cardiac surgery. Glycated haemoglobin (HbA1c) values correspond closely with average blood glucose levels and cut off values can be used to define diabetic and pre-diabetic status. These have been correlated with perioperative events. This narrative review discusses the role of glycated hemoglobin in cardiac surgery.
In-Situ Multiphysical Metrology for Photonic Wire Bonding by Two Photon Polymerization
Authors: Lei Yu , Sun Wentao , Huang Xiaolong , Wang Yan , Gao Jinling , Li Xiaopei , Xiao Rulei , Deng Biwei
Published: September 2024

Femtosecond laser two-photon polymerization (TPP) technology, known for its high precision and capability to fabricate arbitrary 3D structures, has been widely applied in the production of various micro-nano optical devices, achieving significant advancements particularly in the field of photonic wire bonding (PWB) for optical interconnects. Currently, research on optimizing both the optical loss and production reliability of polymeric photonic wires is still in its early stages. One of the key challenges is that inadequate metrology methods cannot meet the demand for multiphysical measurements in practical scenarios. This study utilizes in-situ scanning electron microscopy (SEM), for the first time, to monitor the working PWBs fabricated by TPP technology at the microscale. Optical and mechanical measurements are made simultaneously to evaluate the production qualities and to study the multiphysical coupling effects of PWBs. The results reveal that photonic wires with larger local curvature radii are more prone to plastic failure, while those with smaller local curvature radii recover elastically. Furthermore, larger cross-sectional dimensions contribute dominantly to the improved mechanical robustness. The optical loss deterioration of the elastically deformed photonic wire is only temporary, which can be fully recovered when the load is removed. After further optimization based on the results of multiphysical metrology, the PWBs fabricated in this work achieve a minimum insertion loss of 0.6 dB. In this study, the multiphysical analysis of PWBs carried out by in-situ SEM metrology offers a novel perspective for optimizing the design and performance of microscale polymeric waveguides, which could potentially promote the mass production reliability of TPP technology in the field of chip-level optical interconnection.
RNAi-Mediated Knockdown of CYP321A7 and CYP321A8 in Fall Armyworm Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae) Enhances Susceptibility to Chlorantraniliprole and Thiamethoxam
Authors: D. dela Cruz Raymund Kim , B. Alviar Karen
Published: September 2024

Fall armyworm (FAW), Spodoptera frugiperda, has been causing significant crop losses and has now become the most economically important pest of corn globally. With the challenges arising from the extensive use of synthetic chemicals such as reports that FAW gained resistance to various insecticides, researchers are developing environmentally sound control measures to address these issues. An example is the application of the RNA interference in managing FAW populations. RNA interference is a biological process where dsRNA molecules silence specific gene of interest. Here, dsRNA fragments were generated to target Cytochrome P450 monooxygenases CYP321A7 and CYP321A8 in FAW. Mortality and phenotypic effects of RNAi-mediated knockdown of essential genes of target CYP450s through RNAi in FAW were analyzed. Results showed that RNA in vitro transcription yielded ~14 μg/μL of dsCYP321A7 and dsCYP321A8. The mortality rate of dsCYP321A7- and dsCYP321A8-fed larvae following exposure to insecticide with dual active ingredient of Chlorantraniliprole and Thiamethoxam increased by 90% and 80%, respectively as compared to dsGFP-fed larvae with 40% at 2 days post insecticide exposure. This study provided evidence for the potential of RNAi for FAW management strategies particularly for insecticide-resistant populations, including the potential for biopesticide development.
Neuropsychiatric Adverse Events with Monoclonal Antibodies Approved for Multiple Myeloma: An Analysis from the FDA Adverse Event Reporting System
Authors: Cicala Giuseppe , Russo Giulia , Santoro Vincenza , Franchina Tindara , Silvestris Nicola , Santarpia Mariacarmela , Spina Edoardo , Barbieri Maria Antonietta
Published: September 2024

Background/Objectives: Monoclonal antibodies (mAbs) have revolutionized multiple myeloma (MM) treatment. However, post-marketing data on their neuropsychiatric safety is limited. This study aimed to evaluate neuropsychiatric adverse events (AEs) related to mAbs used for MM through a retrospective pharmacovigilance analysis using the Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) database.
Methods: Individual case safety reports (ICSRs) from 2015 to 2023 with at least one neuropsy-chiatric AE and one of the MM-approved mAbs as the suspect drug (i.e., daratumumab, elo-tuzumab, isatuximab, belantamab mafodotin, teclistamab, elranatamab, and talquentamab) were analyzed using descriptive and disproportionality approaches.
Results: Unknown signals of disproportionate reporting (SDR) included cerebral infarction for daratumumab (n = 45; reporting odds ratio (ROR) = 2.39, 95% confidence interval (CI) = 1.79-3.21; information component (IC) = 1.54, IC025-IC075 = 1.05-1.9), elotuzumab (25; 7.61, 5.13-11.28; 3.03, 2.37-3.51), and isatuximab (10; 2.56, 1.38-4.76; 1.67, 0.59-2.4); mental status changes for daratumumab (40; 2.66, 1.95-3.63; 1.67, 1.14-2.04) and belantamab mafodotin (10; 4.23, 2.28-7.88; 2.3, 1.22-3.03); altered state of consciousness for daratumumab (32; 1.97, 1.39-2.78; 1.32, 0.73-1.74) and belantamab mafodotin (6; 2.35, 1.05-5.23; 1.6, 0.19-2.52); Guil-lain-Barre syndrome (GBS) for daratumumab (23; 6.42, 4.26-9.69; 2.81, 2.11-3.3), isatuximab (8; 10.72, 5.35-21.48; 3.57, 2.35-4.37), and elotuzumab (3; 4.74, 1.53-14.7; 2.59, 0.52-3.8); and orthos-tatic intolerance for daratumumab (10; 12.54, 6.71-23.43; 3.75, 2.67-4.48) and elontuzumab (4; 28.31, 10.58-75.73; 5 , 3.24-6.08).
Conclusions: Our analysis highlighted several previously unacknowledged SDRs for MM-approved mAbs. Given the complex and not entirely understood etiology of some neuropsy-chiatric AEs, including GBS, further investigations are necessary.
Morphological and Performance Biomechanics Profiles of Draft Prep American Style Football Players
Authors: Mokha G. Monique , Berrocales Maria , Rohman Aidan , Schafer Andrew , Stensland Jack , Petruzzelli Joseph , Nasri Ahmad , Thompson Talia , Taha Easa , Bommarito Pete
Published: September 2024

This study profiled morphological and laboratory-derived performance biomechanics by position of American style football players training for the National Football League draft. Fifty-five players were categorized into Big (e.g., lineman; n=17), Big-skill (e.g., tight end; n=11), and Skill (e.g., receiver; n=27) groups. Body fat (BF%), lean body mass (LBM), total body mass, running force and ground contact time (GCT), countermovement jump height (CMJ-JH), CMJ normalized peak power (CMJ-NPP), and reactive strength were measured in a laboratory. Asymmetry was calculated for running force, GCT, and CMJ eccentric and concentric impulse (IMP). MANOVA determined between-group differences, and radar plots for morphological and performance characteristics were created using Z-scores. There was a significant between-group difference, F(26,80)=5.70, p<0.001;Wilk’s Λ=0.123, partial η2=0.649. Fisher’s least squares difference post-hocs showed Skill had greater JH, CMJ-NPP, reactive strength, and running force versus Big but not Big-skill, p<0.05. Big had greater BF%, LBM, total body mass, and GCT than Skill and Big-Skill, p<0.05. Big-skill had greater GCT asymmetry than Skill and Big, p<0.05. Asymmetries in running forces, and CMJ eccentric and concentric IMP were not different, p>0.05. Morphological and performance biomechanics differences are pronounced between Skill and Big. Big-skill possess characteristics from both groups. Laboratory-derived results provide specialized profiles of draft trainees.
Accelerating the Innovation Lifecycle in Innovationology: Cutting-Edge Strategies for Reducing Time-to-Market
Authors: Moleka Pitshou
Published: September 2024

In an era of relentless technological change, accelerating the pace of innovation has become a critical imperative for organizations seeking to maintain a competitive edge and drive meaningful societal progress. Yet the complex, multifaceted innovation process - from ideation to commercialization - is often plagued by bottlenecks and challenges that can significantly delay the time-to-market for groundbreaking new products, services, and business models. This pioneering article represents an outstanding contribution to the burgeoning field of innovationology, offering a comprehensive, evidence-based playbook for shortening the innovation lifecycle. Drawing on an extensive review of over 180 cutting-edge academic sources, the paper maps the key stages of the innovation process - idea generation, concept development, prototyping, testing, and launch - and illuminates cutting-edge strategies that innovators can deploy to overcome common barriers and drive transformative innovations to market more quickly. From advanced idea generation techniques like design thinking and AI-powered creativity to innovative approaches to rapid prototyping, virtual experimentation, and data-driven commercialization, this seminal work equips scholars, practitioners, and policymakers with a transformative, globally-relevant toolkit for accelerating the innovation lifecycle. By synthesizing insights from a diverse array of industries and disciplines, the article establishes a new benchmark for innovationology research and empowers organizations to cultivate the conditions needed to translate visionary ideas into game-changing realities with unprecedented speed and efficiency. As the world grapples with ever-more complex, interconnected challenges, the ability to rapidly develop and scale breakthrough innovations has never been more crucial. This paradigm-shifting contribution to the field of innovationology represents a vital resource for driving the bold, disruptive changes needed to shape a more sustainable, equitable future.
Customer Satisfaction Analysis On Tokopedia Marketplace Services In Jakarta Area
Authors: Lisdza Natasya Rezika , Ferry Wibowo Setyo , Arvinta  Monoarfa Terrylina
Published: September 2024

This research aims to determine the satisfaction factors of Tokopedia marketplace users in Jakarta. This research uses a quantitative approach with descriptive analysis methods. The population in this study includes individuals who currently or have used the Tokopedia marketplace. In this study, samples were taken using no-probability purposive sampling and distributing questionnaires online via Google From. The sample used in this research was 240 respondents. The sample criteria in this research consist of individuals who live in the Jakarta area, aged 17-45 years and users of the Tokopedia marketplace. This research uses validity and reliability tests as research instrument tests. This research only uses two analytical techniques, namely descriptive analysis with the aim of describing or illustrating Tokopedia marketplace user data and then classifying it so that later it can be formulated to get a clear picture of the problems that cause customers to feel satisfied. Then there is the factor analysis technique or Expolatory Factor Analysis which aims to form new factors to support customer satisfaction. This research uses the e-service quality dimension as a measurement of customer satisfaction. There are seven indicators in this research, namely, Efficiency, Fulfillment, Reliability, Privacy, Responsiveness, Compensation, Contact. The results of this research say that by using the EFA analysis technique, three factors have been formed to support customer satisfaction, the names of these three factors are: service reliability and security, customer service quality, customer comfort and efficiency.
Educational Games as Learning Media in the 21st Century for Elementary School Students: A Systematic Literature Review
Authors: Istiq'faroh Nurul , Kiettikunwong Narong , Setiawan Ricky , Muhimmah Hitta Alfi
Published: September 2024

Technology in education is essential in the 21st century. Technology plays an important role in all learning methods today. Educational games can be used in all levels of education. This study presents a systematic literature review on educational games in elementary schools and offers recommendations for future research. This study identified twenty articles that focused on game-based learning in elementary schools. Article quality is assessed at the initial phase of the selection process based on specific criteria. Criteria: Articles published from 2013 to 2022, in English, from journals and proceedings, and open access. This research also explores the level of education, learning models, learning activities, types of research used, use of digital tools, and the impact of games on learning in elementary schools. Incorporating technology in the teaching and learning process can effectively develop students and educators to achieve better learning and educational outcomes. This research study found that educational games integrated with various digital tools were successfully used in elementary schools to achieve learning objectives. Examining these arguments can provide insights for increasing educational effectiveness.
Licensing the removal and storage of human organs and (or) tissues for transplantation: legal problems and solutions.
Authors:   Irkutsk State Medical University Ministry of Health of the Russian Federation, Novozhilov A. V. , Kitsul I. S. ,   Irkutsk State Medical Academy postgraduate education – branch of the Federal State Budgetary Educational Institution of Further Education «Russian Medical Academy of Continuous professional education» of the Ministry of Health of Russia, Piven D. V. ,   Expert on regulatory issues regulation of health care activities.
Published: September 2024

The article examines the problem of licensing medical activities related to the removal and storage of human organs and (or) tissues for transplantation purposes in medical organizations that are donor bases. It is proposed to understand donor bases as medical organizations in which or on the basis of which the collection and procurement of human organs and (or) tissues is carried out for the purpose of their subsequent transplantation in medical organizations that directly carry out transplantation of human organs and (or) tissues. The authors show legal gaps in the current legislation, which lead to difficulties in licensing these types of activities for both licensing authorities and medical organizations. A rationale for possible ways to solve these problems is presented and specific proposals for amending current legislation are presented.
The European Cultural Tradition and Us: the Ideas of M.K. Petrov
Authors:   Institute of Philosophy and Socio-Political Sciences of the Southern Federal University, Drach Gennady
Published: September 2024

The subject of the article is the main problems of the European cultural tradition, considered by M.K. Petrov, and the questions of its specificity and continuity in the historical development from ancient philosophy to experimental sci­ence raised by him. The historical and philosophical context of his formation of the original theory of types of cultures is reconstructed. The rejection of He­gelian panlogism and the position on the universality of a linear development that is uniform for all cultures raises the question of the internal sources of cul­tural development. The article shows that Petrov is looking for answers on the paths of linguistics and the hypothesis of linguistic relativity. Turning to ancient philosophy allows Petrov to reconstruct the intellectual events caused by the emergence of language as a human invention, which broke ties with the former world of stable meanings and opened up the space for the emancipa­tion of the word and the desacralization of knowledge. In this context, the article examines a number of controversial issues about the biocode and sociocode, the name and sign that allowed them to remain the center of an extra-biological system of social coding, and about the diversity of cultures in a polycentric world. Questions are raised about the correlation of Petrov’s positions and mo­dern cultural anthropology
Digital Modeling of Intersubjectivity in Social Construction and Phenomenological Analyses of the World of Everyday Life
Authors:   Institute for Philosophy, Political Science and Religion Studies, Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan, Dunaev Vladimir , Kurganskaya Valentina ,   Institute for Philosophy, Political Science and Religion Studies, Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan, Sagikyzy Ayazhan ,   Institute for Philosophy, Political Science and Religion Studies, Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan
Published: September 2024

The widespread introduction of digital information and communication tech­nologies is changing the very nature of interpersonal and mass social interaction, creating new practices, meanings and forms of intersubjectivity. The article ana­lyzes a number of approaches to the creation of general artificial intelligence (AGI) systems based on the convergence of methods of phenomenological ana­lysis of intentional structures of intersubjectivity with technologies for creating and training artificial neural network systems of generative intelligence – Chat­GPT. It is shown that one of the most promising areas of constructing the cogni­tive architecture of AGI is the theory of frames as modeling schemes or matrices of stereotypical organization and interpretation of everyday experience. This conclusion is based on the fact that frames, as well as the procedures for swit­ching and configuring them, act as a kind of “spiritual automata” that control typical behavior of people in typical situations. The dual role of digital platforms in the social construction of reality is shown. On the one hand, digital platforms allow users to realize their aspirations and express the uniqueness of their indi­viduality, facilitate access to information, etc. On the other hand, our digital alter Ego, generated by intelligent systems, acquires the ability to recursively target, direct and control our thinking, motivations, emotional reactions, etc. The direct digital access to our spiritual life is not an inevitable consequence of the intro­duction of digital technologies into the world of everyday life, but a political project that can and should be sought for effective alternatives
Conceptual Engineering: Idea and Problem Field
Authors:   Moscow Pedagogical State University, Kozlova Natalya
Published: September 2024

The article analyzes the ideas and methods of conceptual engineering, its goals, problem field and opportunities. Conceptual engineering as a philosophical di­rection arises at the intersection of descriptive and normative approaches, repre­senting a revisionist strategy. Emphasizing the correlation between science and social life, the developers of the idea draw attention to the need for a conscious attitude to conceptual representation and terminological choice. Particular atten­tion is paid to the analysis of the name of the direction: the engineering perspec­tive is associated with the idea of ​​managing the scientific process. Theoretical and methodological origins of conceptual engineering are considered: the ideas of J. Dewey on the development of “conscious thinking”, R. Carnap on explica­tion, S. Haslanger on the importance of a critical attitude towards significant so­cial theoretical constructs. It is shown that conceptual engineering as a revi­sionist epistemological project is aimed at changing specific forms of social interaction through the revision of current ideas about the world and about one­self. Given the paramount importance of language in organizing everyday intel­lectual practices, conceptual engineering focuses on concepts and their meaning. In essence, it represents another attempt to eliminate linguistic ambiguity, but no longer with the help of a special symbolic language, but by manipulating mean­ing and sense. The problems of semantic modifications of concepts associated with semantic drift, linguistic intuition and communication, knowledge transfer are analyzed
On the Issue of Epistemology, Consciousness and Intelligence
Authors:   Institute of Philosophy and Sociology, Azerbaijan National Academy of Sciences, Mammadzada Ilham , Dadashova Samira ,   Institute of Philosophy and Sociology, Azerbaijan National Academy of Sciences
Published: September 2024

This paper is devoted to issues of epistemology, which has recently acquired par­ticular relevance in the national philosophy. The role of cultural-historical episte­mology in the modern theory of knowledge is revealed, where the authors hold the idea that knowing the origin and development of knowledge itself, and its cultural conditioning in specific historical experiences contributes to a better un­derstanding of its significance and the scope of use. The authors present their vi­sion of the problem of transition from gnosiology to epistemology as from a strict prescribed methodology to the choice of one’s ways and methods of con­ducting science, where a significant role is given to such disciplines as computer science and logic. In this context, the relationship between consciousness and in­telligence with the theory of knowledge, in particular with cultural-historical epistemology, is also analyzed, since both the philosophy of consciousness and epistemology seek to understand the nature of knowledge and beliefs based on our conscious experience. This approach, considering the influence of social norms, values and cultural traditions on our cognition and thinking, stimulates the development of the theoretical basis of epistemology and its practical appli­cation. The authors conclude that modern research in the field of consciousness and artificial intelligence and their application in the methodology of epistemo­logy contribute not only to rethinking views on the nature of subjectivity but also to establishing the objectivity of our judgments. Ultimately, this leads to the inte­gration of collective and individual consciousness as an important factor in un­derstanding the world and forming scientific knowledge
The Age of Magnanimity: Aristotle’s megalopsychia and Hegel’s die schöne Seele
Authors:   Lomonosov Moscow State University, Ilyina Aleksandra
Published: September 2024

Modernity loves noble aspirations; the image of a hero following the path of ad­venture in order to save the universe and become happy forms the center of many works of art. Often, the image of such a hero is reinforced by the idea of magnanimity, that is, the idea of a moral character that allows its owner to overcome emerging difficulties and cope with outstanding circumstances. However, for a long time, ideas about generosity did not have the degree of un­ambiguity that we put into this word now. For example, in the Middle Ages, generosity was strongly associated with the sin of pride, and therefore commen­tators on Aristotle (for example, Albertus Magnus) tried to find a clear substan­tive difference between magnanimitas and superbia. For this reason, critical concepts of Aristotle and Hegel are interesting, because they show that the great soul (or beautiful soul) does not have noble connotations, for they are ironic (or ordinary). Both Aristotle and Hegel greatly influenced subsequent ideas about generosity; by showing its dual nature, they showed the “other side” of this virtue. This article provides a consistent analysis of Aristotle’s ideas about generosity, set out in the Nicomachean Ethics, and Hegel’s Gestalt, de­scribed in the Phenomenology of Spirit. The final section presents a comparison of the two concepts, revealing which critical foundations are significant for both Hegel and Aristotle, and also describes possible lines of further research
The Russian Idea in Eurasianism and Its Reflection in Contemporary Times
Authors:   Ufa University of Science and Technology, Vakhitov Rustem ,   Ufa State Petroleum Technological University
Published: September 2024

Eurasianism of the 1920s–1930s was one of the most original phenomena of the Russian émigré community. The Eurasianists proposed a new solution to the problem of Russia’s civilizational identity, seeing it neither as Europe, nor Asia, nor as the “center of the Slavic world”, but as a unique, synthetic cultural entity – Eurasia. According to the initial, “right-wing” Eurasianists, the destiny of Russia and the Russian people is to recognize their Eastern roots, their distinc­tion from the West, to lead the uprising of oppressed humanity against the West, and to establish a system of “continental states” that would eliminate the causes of wars and conflicts. The left-wing Eurasianists and the Eurasianists of the 1930s believed that the Russian Revolution opened a new era – an era of collectivism and socialism, but this socialism would not be Marxist; it would be a unique, re­ligious socialism. In the 1990s and 2000s, the phenomenon of neo-Eurasianism emerged. The most prominent “media” figure of neo-Eurasianism was and re­mains A.G. Dugin. However, his understanding of Eurasianism is reduced to a geo­political theory, which appears as the “inverted geopolitics” of H. Mackinder, op­posing Land and Sea. A.G. Dugin understands Eurasia too broadly, including Europe in it, in accordance with the concept of K. Haushofer. Specialists in Eurasianism (particularly M.A. Maslin) rightly note that this contradicts the understanding of Eurasia by the classics of Eurasianism and, in general, the concept of classical Eurasianism. Among other representatives of neo-Eurasianism of the 1990s and 2000s, one can note V.V. Kozhinov, A.S. Panarin, and S.G. Kara-Murza