bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
Authors: Ruiz-Rodríguez Juan Carlos , Chiscano-Camón Luis , Ruiz-Sanmartin Adolf , Palmada Clara , Paola Plata-Menchaca Erika , Franco-Jarava Clara , Pérez-Carrasco Marcos , Hernández-González Manuel , Ferrer Ricard
Published: January 2022

Introduction: A dysregulated inflammatory response, known as “cytokine storm”, plays an important role in the pathophysiology of coronavirus 2019 disease (COVID-19). Identifying patients with a dysregulated inflammatory response and at high risk for severe respiratory failure, organ dysfunction, and death is clinically relevant, as they could benefit from the specific therapies, such as cytokine removal by hemoadsorption. This study aimed to evaluate cytokine hemoadsorption as rescue therapy in critically ill patients with SARS-CoV-2 pneumonia, severe respiratory failure refractory to prone positioning, and hypercytokinemia.

Methods: In this single center, observational and retrospective study, critically ill patients with SARS-CoV-2 pneumonia, severe acute respiratory failure, and hypercytokinemia were analyzed. All the patients underwent cytokine hemoadsorption using CytoSorb® (Cytosorbents Europe, Berlin, Germany). The indication for treatment was acute respiratory failure, inadequate clinical response to the prone position, and hypercytokinemia.

Results: Among a total of 343 patients who were admitted to the intensive care unit (ICU) due to SARS-CoV-2 infection between March 3, 2020 and June 22, 2020, six patients received rescue therapy with cytokine hemoadsorption. All the patients needed invasive mechanical ventilation and prone positioning. A significant difference was found in the pre- and post-treatment D-dimer (17,868 mcg/ml [4,196–45,287] vs. 4,488 mcg/ml [3,166–17,076], p = 0.046), C-reactive protein (12.9 mg/dl [10.6] vs. 3.5 mg/dl [2.8], p = 0.028), ferritin (1,539 mcg/L [764–27,414] vs. 1,197 ng/ml [524–3,857], p = 0.04) and interleukin-6 (17,367 pg/ml [4,539–22,532] vs. 2,403 pg/ml [917–3,724], p = 0.043) levels. No significant differences in the pre- and post-treatment interleukin-10 levels (22.3 pg/ml [19.2–191] vs. 5.6 pg/ml [5.2–36.6], p = 0.068) were observed. Improvements in oxygenation (prehemoadsorption PaO2/FIO2 ratio 103 [18.4] vs. posthemoadsorption PaO2/FIO2 ratio 222 [20.9], p = 0.029) and in the organ dysfunction (prehemoadsorption SOFA score 9 [4.75] vs. posthemoadsorption SOFA score 7.7 [5.4], p = 0.046) were observed. ICU and in-hospital mortality was 33.7%.

Conclusions: In this case series, critically ill patients with COVID-19 with severe acute respiratory failure refractory to prone positioning and hypercytokinemia who received adjuvant treatment with cytokine hemoadsorption showed a significant reduction in IL-6 plasma levels and other inflammatory biomarkers. Improvements in oxygenation and SOFA score were also observed.
Relief After COVID-19 Vaccination: A Doubtful or Evident Outcome?
Authors: Al-Hanawi Mohammed Khaled , Alshareef Noor , El-Sokkary Rehab H.
Published: January 2022

Background:Since development of the first COVID-19 vaccine, the landscape of public confidence in these vaccines is uncertain. Building confidence is crucial for better preparedness of future pandemics. Following the mandatory COVID-19 vaccination policy in the country, the aim of this study was to examine whether the Saudi public feels relieved post-vaccination and to identify the factors predicting such relief.

Methods:An online cross-sectional survey was conducted in July 2021 among COVID-19 vaccine recipients in Saudi Arabia. A multivariable logistic regression analysis was employed to examine and identify the variables associated with feeling relieved post-vaccination.

Results:Most of the respondents (66%) stated feeling more relieved post-vaccination. Male gender [adjusted odds ratio (AOR): 1.380; 95% confidence interval (CI): 0.981–1.943], being a student (AOR: 3.902; 95% CI: 1.674–9.096), and received two doses of the vaccine (AOR: 2.278; 95% CI: 1.630–3.182) were associated with feeling more relieved after getting vaccinated. Respondents who were anxious about the vaccine before receiving it (AOR: 0.220; 95% CI: 0.160–0.302), and experienced a severe reaction after vaccination (AOR: 0.288; 95% CI: 0.165–0.504) had lower odds of feeling relieved post-vaccination. Respondents who relied on social media as the main source of vaccine-related information and those having no information about the vaccine were also less likely to feel relieved post-vaccination.

Conclusions:Individuals' attitudes toward COVID-19 vaccines may not necessarily alter post-vaccination. Although mandatory vaccination policies can significantly contribute to achieving herd immunity, public confidence toward vaccines might be eroded, which could in turn impose significant challenges in future pandemics efforts.
Mechanism of Intermittent Deep Tillage and Different Depths Improving Crop Growth From the Perspective of Rhizosphere Soil Nutrients, Root System Architectures, Bacterial Communities, and Functional Profiles
Authors: Gu Yabing , Liu Yongjun , Li Jiaying , Cao Mingfeng , Wang Zhenhua , Li Juan , Meng Delong , Cao Peijian , Duan Shuhui , Zhang Mingfa , Tan Ge , Xiong Jing , Yin Huaqun , Zhou Zhicheng
Published: January 2022

Long-term conventional shallow tillage reduced soil quality and limited the agriculture development. Intermittent deep tillage could effectively promote agricultural production, through optimizing soil structure, underground ecology system, and soil fertility. However, the microecological mechanism of intermittent deep tillage promoting agriculture production has never been reported, and the effect of tillage depth on crop growth has not been explored in detail. In this study, three levels of intermittent deep tillage (30, 40, and 50 cm) treatments were conducted in an experimental field site with over 10 years of conventional shallow tillage (20 cm). Our results indicated that intermittent deep tillage practices helped to improve plant physiological growth status, chlorophyll a, and resistance to diseases, and the crop yield and value of output were increased with the deeper tillage practices. Crop yield (18.59%) and value of output (37.03%) were highest in IDT-50. There were three mechanisms of intermittent deep tillage practices that improved crop growth: (1) Intermittent deep tillage practices increased soil nutrients and root system architecture traits, which improved the fertility and nutrient uptake of crop through root system. (2) Changing rhizosphere environments, especially for root length, root tips, pH, and available potassium contributed to dissimilarity of bacterial communities and enriched plant growth-promoting species. (3) Functions associated with stress tolerance, including signal transduction and biosynthesis of other secondary metabolites were increased significantly in intermittent deep tillage treatments. Moreover, IDT-30 only increased soil characters and root system architecture traits compared with CK, but deeper tillage could also change rhizosphere bacterial communities and functional profiles. Plant height and stem girth in IDT-40 and IDT-50 were higher compared with IDT-30, and infection rates of black shank and black root rot in IDT-50 were even lower in IDT-40. The study provided a comprehensive explanation into the effects of intermittent deep tillage in plant production and suggested an optimal depth.
Synthesis of Abscisic Acid in Neopyropia yezoensis and Its Regulation of Antioxidase Genes Expressions Under Hypersaline Stress
Authors: Yang Jiali , Gu Wenhui , Feng Zezhong , Yu Bin , Niu Jianfeng , Wang Guangce
Published: January 2022

Abscisic acid (ABA) is regarded as crucial for plant adaptation to water-limited conditions and it functions evolutionarily conserved. Thus, insights into the synthesis of ABA and its regulation on downstream stress-responsive genes in Neopyropia yezoensis, a typical Archaeplastida distributed in intertidal zone, will improve the knowledge about how ABA signaling evolved in plants. Here, the variations in ABA contents, antioxidant enzyme activities and expression of the target genes were determined under the presence of exogenous ABA and two specific inhibitors of the ABA precursor synthesis. ABA content was down-regulated under the treatments of each or the combination of the two inhibitors. Antioxidant enzyme activities like SOD, CAT and APX were decreased slightly with inhibitors, but up-regulated when the addition of exogenous ABA. The quantitative assays using real-time PCR (qRT-PCR) results were consistent with the enzyme activities. All the results suggested that ABA can also alleviate oxidative stress in N. yezoensis as it in terrestrial plant. Combined with the transcriptome assay, it was hypothesized that ABA is synthesized in N. yezoensis via a pathway that is similar to the carotenoid pathway in higher plants, and both the MVA and that the MEP pathways for isoprenyl pyrophosphate (IPP) synthesis likely exist simultaneously. The ABA signaling pathway in N. yezoensis was also analyzed from an evolutionary standpoint and it was illustrated that the emergence of the ABA signaling pathway in this alga is an ancestral one. In addition, the presence of the ABRE motif in the promoter region of antioxidase genes suggested that the antioxidase system is regulated by the ABA signaling pathway.
Associations Between Oral Health Status, Perceived Stress, and Neuropsychiatric Symptoms Among Community Individuals With Alzheimer's Disease: A Mediation Analysis
Authors: Yang Bing , Tao Binbin , Yin Qianyu , Chai Zhaowu , Xu Ling , Zhao Qinghua , Wang Jun
Published: January 2022

Community individuals with Alzheimer's disease (AD) experience oral disease alongside neuropsychiatric symptoms (NPS) with disease progression. Despite growing evidence for the link between oral health and cognitive status, few studies have investigated the associations between oral health and NPS, especially based on individuals' experience of AD. The primary aim of this study was to examine (a) the difference in oral health-related stressors among individuals with AD, mild cognitive impairment (MCI), and subjective cognitive decline (SCD); and (b) the associations of these stressors with NPS under the framework of the stress process model (SPM). A cross-sectional study was conducted among individuals diagnosed with AD (n = 35), MCI (n = 36) or SCD (n = 35), matched for age, sex education, and body mass index (BMI). Multiple regression and mediation model analyses were performed to explore predictors and their relationships with NPS based on the SPM. Data collection comprised four sections: (a) individual context; (b) oral health-related stressors, including dental caries, periodontal status, oral hygiene, the geriatric oral health assessment index (GOHAI), oral salivary microbiota, pro-inflammatory cytokines, and oral health behavior; (c) subjective stressors (i.e., perceived stress [PS]); and (d) NPS. Decayed, missing, and filled teeth (DMFT), missing teeth (MT), loss of attachment (LoA), plaque index (PLI), PS, oral health behavior, GOHAI, pro-inflammatory cytokines, and salivary bacterial composition were significantly different among the three groups; these parameters were poorer in the AD group than SCD and/or MCI group. LoA, PLI, PS, and pain or discomfort in the GOHAI were directly associated with NPS. PLI, LoA, and psychosocial function in the GOHAI indirectly affected NPS, and this relationship was mediated by PS. Individuals with AD reported greater oral health-related stressors. This study identifies direct and indirect associations linking oral health-related stressors and PS with NPS in individuals with AD. Our findings suggest that targeted dental care and oral-related stressor control may be valuable for managing NPS.
Transcranial Direct Current Stimulation on Parkinson's Disease: Systematic Review and Meta-Analysis
Authors: Oliveira Paloma Cristina Alves de , Araújo Thiago Anderson Brito de , Machado Daniel Gomes da Silva , Rodrigues Abner Cardoso , Bikson Marom , Andrade Suellen Marinho , Okano Alexandre Hideki , Simplicio Hougelle , Pegado Rodrigo , Morya Edgard
Published: January 2022

Background: Clinical impact of transcranial direct current stimulation (tDCS) alone for Parkinson's disease (PD) is still a challenge. Thus, there is a need to synthesize available results, analyze methodologically and statistically, and provide evidence to guide tDCS in PD.

Objective: Investigate isolated tDCS effect in different brain areas and number of stimulated targets on PD motor symptoms.

Methods: A systematic review was carried out up to February 2021, in databases: Cochrane Library, EMBASE, PubMed/MEDLINE, Scopus, and Web of science. Full text articles evaluating effect of active tDCS (anodic or cathodic) vs. sham or control on motor symptoms of PD were included.

Results: Ten studies (n = 236) were included in meta-analysis and 25 studies (n = 405) in qualitative synthesis. The most frequently stimulated targets were dorsolateral prefrontal cortex and primary motor cortex. No significant effect was found among single targets on motor outcomes: Unified Parkinson's Disease Rating Scale (UPDRS) III – motor aspects (MD = −0.98%, 95% CI = −10.03 to 8.07, p = 0.83, I2 = 0%), UPDRS IV – dyskinesias (MD = −0.89%, CI 95% = −3.82 to 2.03, p = 0.55, I2 = 0%) and motor fluctuations (MD = −0.67%, CI 95% = −2.45 to 1.11, p = 0.46, I2 = 0%), timed up and go – gait (MD = 0.14%, CI 95% = −0.72 to 0.99, p = 0.75, I2 = 0%), Berg Balance Scale – balance (MD = 0.73%, CI 95% = −1.01 to 2.47, p = 0.41, I2 = 0%). There was no significant effect of single vs. multiple targets in: UPDRS III – motor aspects (MD = 2.05%, CI 95% = −1.96 to 6.06, p = 0.32, I2 = 0%) and gait (SMD = −0.05%, 95% CI = −0.28 to 0.17, p = 0.64, I2 = 0%). Simple univariate meta-regression analysis between treatment dosage and effect size revealed that number of sessions (estimate = −1.7, SE = 1.51, z-score = −1.18, p = 0.2, IC = −4.75 to 1.17) and cumulative time (estimate = −0.07, SE = 0.07, z-score = −0.99, p = 0.31, IC = −0.21 to 0.07) had no significant association.

Conclusion: There was no significant tDCS alone short-term effect on motor function, balance, gait, dyskinesias or motor fluctuations in Parkinson's disease, regardless of brain area or targets stimulated.
DFT Study on the Substituent Effect of Anticancer Picoline-Diazido-Pt(IV) Compounds
Authors: Mu Meilin , Gao Hongwei
Published: January 2022

The geometric structure of azido Pt(IV) compounds containing picoline was calculated by using density functional theory(DFT) at the LSDA/SDD level. The ESP distribution shows the possible reaction sites of the compounds. In addition, the frequency calculation results assigned the infrared spectra of these compounds, and specified important stretching and bending vibrations. The HOMO-LUMO energy gaps of these compounds are also calculated to explain the charge transfer of the molecules. The distribution of Mulliken charges and natural atomic charges of these atoms is also calculated. Natural bond orbital(NBO) analysis explains the intramolecular interactions and their electron density.
Total Protein–Chloride Ratio in Pleural Fluid Independently Predicts Overall Survival in Malignant Pleural Effusion at the First Diagnosis
Authors: Qiao Xin , Zhang Zhi-Rong , Shi Xin-Yu , Yi Feng-Shuang
Published: January 2022

Objective

Pre-treatment biomarkers to estimate overall survival (OS) for malignant pleural effusion (MPE) are unidentified, especially those in pleural fluid. We evaluated the relationship between OS and total protein–chloride ratio in malignant pleural effusion (PE TPClR).

Materials and Methods

A retrospective study was undertaken to identify patients from 2006 to 2018 who had pathologically or cytologically confirmed MPE and received no tumor-targeted therapy. We recorded the pre-treatment clinicopathologic characteristics and follow-up status. OS was estimated by the Kaplan–Meier method, and the association between variables and OS was evaluated by Cox proportional hazards models.

Results

We screened 214 patients who met the eligibility criteria. The optimal cutoff value for the PE TPClR was set at 0.53. The univariate analysis showed that there was a significant correlation between PE TPClR and OS (P < 0.001). The multivariate analysis between OS and the variables selected from the univariate analysis showed that the levels of neutrophil, alkaline phosphatase, neuron-specific enolase, platelets, albumin in peripheral blood, and white blood cells in pleural effusion were also independent predictors of OS.

Conclusion

In patients with MPE, pre-treatment PE TPClR independently predicts OS. Although further research is necessary to generalize our results, this information will help clinicians and patients to determine the most appropriate treatment for MPE patients.
PIWIL1 Drives Chemoresistance in Multiple Myeloma by Modulating Mitophagy and the Myeloma Stem Cell Population
Authors: Wang Yajun , Yao Lan , Teng Yao , Yin Hua , Wu Qiuling
Published: January 2022

As an important member of the Argonaute protein family, PIWI-like protein 1 (PIWIL1) plays a key role in tumor cell viability. However, the exact function of PIWIL1 in multiple myeloma (MM) and the underlying mechanism remain unclear. Here, we revealed that PIWIL1 was highly expressed in myeloma cell lines and newly diagnosed MM patients, and that its expression was notably higher in refractory/relapsed MM patients. PIWIL1 promoted the proliferation of MM cells and conferred resistance to chemotherapeutic agents both in vitro and in vivo. More importantly, PIWIL1 enhanced the formation of autophagosomes, especially mitophagosomes, by disrupting mitochondrial calcium signaling and modulating mitophagy-related canonical PINK1/Parkin pathway protein components. Mitophagy/autophagy inhibitors overcome PIWIL1-induced chemoresistance. In addition, PIWIL1 overexpression increased the proportion of side population (SP) cells and upregulated the expression of the stem cell-associated genes Nanog, OCT4, and SOX2, while its inhibition resulted in opposite effects. Taken together, our findings demonstrated that PIWIL1 induced drug resistance by activating mitophagy and regulating the MM stem cell population. PIWIL1 depletion significantly overcame drug resistance and could be used as a novel therapeutic target for reversing resistance in MM patients.
Food Hypersensitivity in Children Aged 0–3 Years of the Lviv Region in Ukraine: A Cross-Sectional Study
Authors: Matsyura Oksana , Besh Lesya , Borysiuk Olena , Gutor Taras , Malska Andriana , Kovalska Oksana , Besh Olesia , Sorokopud Olena , Vari Sandor G.
Published: January 2022

Aim: To determine the prevalence and to estimate factors associated with food hypersensitivity in young children of the Lviv region in Ukraine.

Methods: A prospective cross-sectional survey study was conducted between 2016 and 2017 in the Lviv region of Ukraine. A specially designed questionnaire about food hypersensitivity of young children developed and validated by M. J. Flokstra-de Blok was used after translation into the Ukrainian language. The questionnaire included 34 questions, grouped into general and detailed information. Parents of children aged 0–3 years were asked to complete the questionnaire at pre-schools and medical institutions.

Results: Among 4,500 distributed questionnaires, 3,214 (71%) were completed and processed. Parents reported that 25% of their young children had food hypersensitivity. According to the survey the most common agents involved in food hypersensitivity in young children were cow's milk (34%), egg (28%), and wheat (24%). Hypersensitivity to milk occurred in 50% of children in the age group of 1–2 years. Regional differences associated with food hypersensitivity were also found. Namely, in the Carpathians, there was more hypersensitivity to fish (27%) and honey (22%) than in other regions, while hypersensitivity to soy was detected mostly in Lviv City residents (8.5%). Unknown causes of food hypersensitivity were highly reported (34%) in the Carpathians.

Conclusion: Prevalence and some distinctiveness of food hypersensitivity revealed in four geographic and climate zones as well as in Lviv City have a considerable practical use for formulation of recommendations for children with food hypersensitivity.
Establishment of an Olfactory Region-specific Intranasal Delivery Technique in Mice to Target the Central Nervous System
Authors: Flamm Johannes , Hartung Sunniva , Gänger Stella , Maigler Frank , Pitzer Claudia , Schindowski Katharina
Published: January 2022

We have recently developed a region-specific catheter-based intranasal application method in mice by using CT scan-based 3D cast models of the murine nose (DOI: 10.2376/0005-9366-17,102). This technique is able to specifically deliver drugs to the olfactory region or to the respiratory region only. Thereby, intranasally administered drugs could be delivered either via neuronal connections to the central nervous system or via the well-perfused rostral parts of the nasal mucosa to the systemic circulation. In the present study, we transferred successfully this novel delivery technique to C57Bl/6 mice and determined parameters such as insertions depth of the catheter and maximum delivery volume in dependence to the weight of the mouse. Breathing was simulated to verify that the volume remains at the targeted area. A step-by-step procedure including a video is presented to adopt this technique for standardized and reproducible intranasal central nervous system (CNS) delivery studies (DOI: 10.3390/pharmaceutics13111904).
Role of Higenamine in Heart Diseases: A Mini-Review
Authors: Wen Jianxia , Li Mingjie , Zhang Wenwen , Wang Haoyu , Bai Yan , Hao Junjie , Liu Chuan , Deng Ke , Zhao Yanling
Published: January 2022

Higenamine, a natural product with multiple targets in heart diseases, is originally derived from Aconitum, which has been traditionally used in China for the treatment of heart disease, including heart failure, arrhythmia, bradycardia, cardiac ischemia/reperfusion injury, cardiac fibrosis, etc. This study is aimed to clarify the role of higenamine in heart diseases. Higenamine has effects on improving energy metabolism of cardiomyocytes, anti-cardiac fibroblast activation, anti-oxidative stress and anti-apoptosis. Accumulating evidence from various studies has shown that higenamine exerts a wide range of cardiovascular pharmacological effects in vivo and in vitro, including alleviating heart failure, reducing cardiac ischemia/reperfusion injury, attenuating pathological cardiac fibrosis and dysfunction. In addition, several clinical studies have reported that higenamine could continuously increase the heart rate levels of healthy volunteers as well as patients with heart disease, but there are variable effects on systolic blood pressure and diastolic blood pressure. Moreover, the heart protection and therapeutic effects of higenamine on heart disease are related to regulating LKB1/AMPKα/Sirt1, mediating the β2-AR/PI3K/AKT cascade, induction of heme oxygenase-1, suppressing TGF-β1/Smad signaling, and targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway. However, the interventional effects of higenamine on heart disease and its underlying mechanisms based on experimental studies have not yet been systematically reviewed. This paper reviewed the potential pharmacological mechanisms of higenamine on the prevention, treatment, and diagnosis of heart disease and clarified its clinical applications. The literature shows that higenamine may have a potent effect on complex heart diseases, and proves the profound medicinal value of higenamine in heart disease.
Intersubjectivity: Conceptual Considerations in Meaning-Making With a Clinical Illustration
Authors: Harrison Alexandra , Tronick Ed
Published: January 2022

This manuscript explores intersubjectivity through a conceptual construct for meaning-making that emphasizes three major interrelated elements–meaning making in interaction, making meaning with the body as well as the mind, and meaning making within an open dynamic system. These three elements are present in the literature on intersubjectivity with a wide range of terms used to describe various theoretical formulations. One objective of this manuscript is to illustrate how such a construct can be useful to understand the meaning-making observed in psychoanalysis, such as in the treatment of a young child on the autistic spectrum. The challenges in establishing an intersubjective state with a child on the autistic spectrum serve to highlight important features of intersubjectivity. As an important background to this clinical illustration, we illustrate the construct with the scientific paradigm of the well-known face-to-face still-face.
Experimental Phenomenology as an Approach to the Study of Contemplative Practices
Authors: Lundh Lars-Gunnar
Published: January 2022

During history humans have developed a large variety of contemplative practices, in many different areas of life, and as part of many different traditions and contexts. Although some contemplative practices are very old, the research field of Contemplation Studies is young, and there are no agreed-upon definitions of central concepts such as contemplative practices and contemplative experiences. The present paper focuses on contemplative practices, defined as practices that are engaged in for the sake of the contemplative experiences they afford (e.g., the contemplation of nature, or the contemplation of various aspects of being-in-the world). The purpose of the present paper is to discuss the potential of experimental phenomenology to contribute to the development of the research field of Contemplation Studies. Experimental phenomenology is defined as the investigation of phenomenological practices and their effects on experience. Phenomenological practices involve intentional variations of experiencing by means of changes in the direction of attention and the choice of attitude, typically as guided by verbal instructions or self-instructions. It is suggested that contemplative practices represent a subcategory of phenomenological practices. Two different varieties of experimental phenomenology are described and illustrated in the present paper: (1) an informal variety which involves the development of new phenomenological practices by creative variation of procedures and observation of effects; and (2) a more rigorously scientific variety, which involves the systematic variation of phenomenological practices in accordance with experimental designs to study their experiential effects. It is suggested that the development of contemplative practices during the ages is the result of an informal experimenting of the first kind; this variety of experimental phenomenology can also be used to develop personalized health interventions in a clinical setting. As to the more rigorously scientific experimental phenomenology, it is possible that it may lead not only to an improved understanding of general principles underlying contemplative practices, but also to a more systematic development of new contemplative practices. The experimental-phenomenological approach to contemplative practices is illustrated by various examples involving mindfulness, gratitude, receiving and giving.
The Influencing Legal and Factors of Migrant Children’s Educational Integration Based on Convolutional Neural Network
Authors: Zhang Chi , Wang Gang , Zhou Jinfeng , Chen Zhen
Published: January 2022

This research aims to analyze the influencing factors of migrant children’s education integration based on the convolutional neural network (CNN) algorithm. The attention mechanism, LSTM, and GRU are introduced based on the CNN algorithm, to establish an ALGCNN model for text classification. Film and television review data set (MR), Stanford sentiment data set (SST), and news opinion data set (MPQA) are used to analyze the classification accuracy, loss value, Hamming loss (HL), precision (Pre), recall (Re), and micro-F1 (F1) of the ALGCNN model. Then, on the big data platform, data in the Comprehensive Management System of Floating Population and Rental Housing, Student Status Information Management System, and Student Information Management System of Beijing city are taken as samples. The ALGCNN model is used to classify and compare related data. It is found that in the MR, STT, and MPQA data sets, the classification accuracy and loss value of the ALGCNN model are better than other algorithms. HL is the lowest (15.2 ± 1.38%), the Pre is second only to the BERT algorithm, and the Re and F1 are both higher than other algorithms. From 2015 to 2019, the number of migrant children in different grades of elementary school shows a gradual increase. Among migrant children, the number of migrant children from other counties in this province is evidently higher than the number of migrant children from other provinces. Among children of migrant workers, the number of immigrants from other counties in this province is also notably higher than the number of immigrants from other provinces. With the gradual increase in the years, the proportion of township-level expenses shows a gradual decrease, whereas the proportion of district and county-level expenses shows a gradual increase. Moreover, the accuracy of the ALGCNN model in migrant children and local children data classification is 98.6 and 98.9%, respectively. The proportion of migrant children in the first and second grades of a primary school in Beijing city is obviously higher than that of local children (p < 0.05). The average final score of local children was greatly higher than that of migrant children (p < 0.05), whereas the scores of migrant children’s listening methods, learning skills, and learning environment adaptability are lower, which shows that an effective text classification model (ALGCNN) is established based on the CNN algorithm. In short, the children’s education costs, listening methods, learning skills, and learning environment adaptability are the main factors affecting migrant children’s educational integration, and this work provides a reference for the analysis of migrant children’s educational integration.
How a Star’s Death Can Reveal a Black Hole
Authors: Arcavi Iair
Published: January 2022

Studying invisible objects in space that are hundreds of millions of light years away may sound impossible. But, in recent years, astronomers have developed a new way to investigate a type of invisible and distant objects—super-massive black holes. Black holes are the most densely packed objects in the Universe. When stars get close to super-massive black holes they can be torn apart, which produces a relatively brief but informative flash of light. These star-destroying events can help us to discover the locations of the most massive black holes in the Universe, but only if we know how to find and interpret them. In this article, we will discuss different ways we can “see” black holes, and particularly what we do and do not yet understand about stars getting “tidally disrupted” by them.

Light Year

The distance light travels in a year, which is 5,878,625,370,000 miles.
Cognitive Ability as a Non-modifiable Risk Factor for Post-prostatectomy Urinary Incontinence: A Double-Blinded, Prospective, Single-Center Trial
Authors: Reichert Mathias , Popeneciu Ionel Valentin , Uhlig Annemarie , Trojan Lutz , Mohr Mirjam Naomi
Published: January 2022

Introduction: Urinary incontinence (UI) is a wide-spread and feared side-effect of conventional or even robot-assisted laparoscopic prostatectomy (RALP) due to its high impact on patients' quality of life (QoL). Non-modifiable risk factors for UI have already been identified – on surgical and patient side. Yet, to our knowledge, focus thus far has not been placed on functional aspects regarding general cognitive ability.

Materials and Methods: This is an observational single-center, prospective, double-blinded evaluation of 109 RALPs performed between 07/2020 and 03/2021. All patients underwent a Mini Mental State Examination (MMSE) prior to surgery to evaluate their cognitive ability. Early post-prostatectomy incontinence (PPI) was evaluated using a standardized 1 h pad test performed 24 h after removal of the urinary catheter. The association between MMSE results and PPI were evaluated using univariate and multivariate logistic regression models.

Results: Multivariate logistic regression analyses identified MMSE results and nerve sparing (NS) as independent predictors for PPI in patients with an intermediate MMSE result (25–27 points) having a 3.17 times higher risk of PPI when compared to patients with a good MMSE result (≥28) (95% Confidence Interval (CI): 1.22–9.06, p = 0.023), while patients without NS had a 3.53 times higher risk of PPI when compared to patients with NS (95% CI: 1.54–11.09, p = 0.006).

Conclusion: A lower cognitive ability should be treated as a non-modifiable risk-factor for early PPI. In the future it could find its place as a clinical screening tool to identify patients who require more attention especially in the pre-, but also in the postoperative phase.
Modeling and Experiments of an Annular Multi-Channel Magnetorheological Valve
Authors: Yang Xiaolong , Chen Yingjie , Liu Yuting , Zhang Ruibo
Published: January 2022

With the increasing number of cars, the demand for vehicle maintenance lifts is also increasing. The hydraulic valve is one of its core components, but there are problems with it such as inaccurate positioning and failure. In order to improve the service performance of vehicle maintenance elevators, a novel annular multi-channel magnetorheological (MR) valve structure was creatively proposed based on intelligent material MR fluid (MRF), and its magnetic circuit was designed. The influence of current, damping gap and coil turns on the pressure drop performance of the annular multi-channel MR valve was numerically studied and compared with ordinary type magnetorheological valve pressure drop performance through contrast and analysis. The influence of different loads and currents on the pressure drop performance of annular multi-channel magnetorheological valve was verified by experiments, and the reliability of numerical analysis results was verified. The results show that the single winding excitation coil is 321 to meet the demand. The pressure drop performance of the annular multi-channel magnetorheological valve is 5.6 times that of the ordinary magnetorheological valve. The load has little influence on the regulating range and performance of pressure drop of the MR valve. Compared with the common type, the pressure drop performance of the annular multi-channel MR Valve is improved by 3.7 times, which is basically consistent with the simulation results.
Study on the Tribological Properties of F-T DS/ZnFe-LDH Composite Lubricating Material
Authors: Wang Jian , Liu Tianxia
Published: January 2022

The homemade soot capture device was used to burn Fischer-Tropsch synthetic diesel (F-T diesel) in order to simulate the combustion of F-T diesel in the engine and collect its soot (F-T DS, FS). The zinc-iron hydrotalcite (ZnFe-LDH) and the composite materials of FS and ZnFe-LDH (F-T DS/ZnFe-LDH, FS/ZnFe-LDH) were prepared by hydrothermal synthesis, and the similarities and differences in tribological characteristics of the above three lubricating materials such as 10# white oil (10# WO) lubricant additives were investigated. FS is an aggregation composed of amorphous carbon and graphite microcrystals. ZnFe-LDH is mainly composed of nanosheets, Zn, and Fe hydroxide particles, with a high degree of crystallization, while FS/ZnFe-LDH is a “sandwich layer” composed of nanosheets and soot particles. Because of the addition of cetyltrimethylammonium bromide and the grafting of a long carbon chain lipophilic group in the preparation process, FS/ZnFe-LDH has better anti-wear properties than the FS and ZnFe-LDH Effect. When FS/ZnFe-LDH is added at 0.2 wt.%, the average friction coefficient (AFC) and average wears scar diameter (AWSD) are at their lowest. Compared with pure 10# WO, the minimum values of AFC and AWSD have dropped by 36.84% and 22.58%, respectively. XPS analysis of the wear scar surface shows that when ZnFe-LDH and FS/ZnFe-LDH are used as lubricating additives of 10# WO, together with the organic matter in the white oil and the iron element in the friction pair, tribochemistry occurs under the combined action of the adsorption force and the tribochemical reaction, a friction protection film containing four elements of C, O, Fe, and Zn is formed on the surface of the wear scar, which effectively reduces the wear and reduces the friction coefficient.
Following the Thread: Elite Iconography on Weaving Objects at Poggio Civitate (Murlo)
Authors: Donoghue Nora K.
Published: January 2022

Evidence for industrial scale production of numerous manufacturing processes has been attested in all phases of occupation at Poggio Civitate (Murlo). A subset of these, tools for the production of textiles and fibers, indicates that textile crafts were manufactured on a large scale as a part of a centralized and organized industry. These industrialized practices occurred within and around the monumental seventh and sixth century BCE complexes which displayed architectural decoration bearing iconographic themes that served to secure the positions of the aristocratic elites. This paper investigates the stamped decoration present on rocchetti and its relationship to the architectural decoration present on the monumental structures of the site. As small moveable objects used by members of the community, rocchetti present an opportunity to investigate the movement of elite images through the non-elite population of a community and their reception of aristocratic ideology presented in monumental structures.
Experimental Study on the Reliability of Scaling Down Techniques Used in Direct Shear Tests to Determine the Shear Strength of Rockfill and Waste Rocks
Authors: Deiminiat Akram , Li Li
Published: January 2022

The determination of shear strength parameters for coarse granular materials such as rockfill and waste rocks is challenging due to their oversized particles and the minimum required ratio of 10 between the specimen width (W) and the maximum particle size (dmax) of tested samples for direct shear tests. To overcome this problem, a common practice is to prepare test samples by excluding the oversized particles. This method is called the scalping scaling down technique. Making further modifications on scalped samples to achieve a specific particle size distribution curve (PSDC) leads to other scaling down techniques. Until now, the parallel scaling down technique has been the most popular and most commonly applied, generally because it produces a PSDC parallel and similar to that of field material. Recently, a critical literature review performed by the authors revealed that the methodology used by previous researchers to validate or invalidate the scaling down techniques in estimating the shear strength of field materials is inappropriate. The validity of scaling down techniques remains unknown. In addition, the minimum required W/dmax ratio of 10, stipulated in ASTM D3080/D3080M-11 for direct shear tests, is not large enough to eliminate the specimen size effect (SSE). The authors’ recent experimental study showed that a minimum W/dmax ratio of 60 is necessary to avoid any SSE in direct shear tests. In this study, a series of direct shear tests were performed on samples with different dmax values, prepared by applying scalping and parallel scaling down techniques. All tested specimens had a W/dmax ratio equal to or larger than 60. The test results of the scaled down samples with dmax values smaller than those of field samples were used to establish a predictive equation between the effective internal friction angle (hereafter named “friction angle”) and dmax, which was then used to predict the friction angles of the field samples. Comparisons between the measured and predicted friction angles of field samples demonstrated that the equations based on scalping scaling down technique correctly predicted the friction angles of field samples, whereas the equations based on parallel scaling down technique failed to correctly predict the friction angles of field samples. The scalping down technique has been validated, whereas the parallel scaling down technique has been invalidated by the experimental results presented in this study.
Concrete Overstrength: Assessment of Field Strength Seeking Insights for Overdesign Optimization
Authors: Antunes Rodrigo
Published: January 2022

This study investigates the high contents of cementitious materials in Portland cement concrete and assesses the required (f’cr) and actual (σ) compressive strength of concrete specimens. A linear optimization technique identifies the required binder content to reach f’cr. Standard specifications have required concrete overdesign (OD) for decades, but few studies have evaluated the actual magnitude of OD from field data. The compressive strength of 958 cylinders prepared in the field represented 8200 m3 of ready-mixed concrete with 300 and 450 kg/m3 of cementitious are analyzed. The actual OD appears to be 7 to 21% higher than required. The required 28-day compressive strength of concrete was achieved in less than seven days. Therefore, the content of the cementitious materials could be reduced by 6 and 17% so that concrete could reach f’cr without cementitious overconsumption. Reducing cementitious content is recommended to improve construction quality and optimize resource utilization. Among the main reasons for this recommendation are the estimated substantial long-term savings, increased concrete durability and more rational use of natural resources required to build the structures.
Fluid Characteristics Analysis of the Lubricating Oil Film and the Wear Experiment Investigation of the Sliding Bearing
Authors: Du Fengming , Chen Changduo , Zhang Kaiguang
Published: January 2022

The sliding bearing is an important component in machines. The characteristics of the oil film fluid of the sliding bearing is the key factor affecting lubrication, which will affect the wear and reliability of the sliding bearing. Herein, the lubricating oil of the sliding bearing is studied, the oil film flow model considering the cavitation effect is established, the pressure and temperature distribution of the oil film under different rotational speeds is explored, and its influence on oil film pressure and temperature are analyzed. Furthermore, wear tests are carried out to measure the wear amount of the bearing bush under different rotational speeds, and the influence of the fluid characteristics of the lubricating oil film on bearing wear is explored. The simulation and experimental study in this paper can provide a reference for the design of sliding bearings.
Landscape Characteristics Affecting Small Mammal Occurrence in Heterogeneous Olive Grove Agro-Ecosystems
Authors: Barão Isabel , Queirós João , Vale-Gonçalves Hélia , Paupério Joana , Pita Ricardo
Published: January 2022

Understanding how small mammals (SM) are associated with environmental characteristics in olive groves is important to identify potential threats to agriculture and assess the overall conservation value and functioning of agro-ecosystems. Here, we provide first insights on this topic applied to traditional olive groves in northeast (NE) Portugal by assessing the landscape attributes that determine SM occurrence, focusing on one species of conservation concern (Microtus cabrerae Thomas 1906) and one species often perceived as a potential pest of olives (Microtus lusitanicus Gerbe 1879). Based on SM genetic non-invasive sampling in 51 olive groves and surrounding habitats, we identified seven rodent species and one insectivore. Occupancy modelling indicated that SM were generally less detected within olive groves than in surrounding habitats. The vulnerable M. cabrerae reached a mean occupancy (95% CI) of 0.77 (0.61–0.87), while M. lusitanicus stood at 0.37 (0.24–0.52). M. cabrerae was more likely to occur in land mosaics with high density of agricultural field edges, while M. lusitanicus was more associated with high density of pastureland patches. Overall, our study suggests that the complex structure and spatial heterogeneity of traditionally managed olive grove agro-ecosystems may favor the occurrence of species-rich SM communities, possibly including well-established populations of species of conservation importance, while keeping potential pest species at relatively low occupancy rates.
Safety Related to the Timing of Radiotherapy and Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer: A Single Institutional Experience
Authors: Tjong Michael C. , Ragulojan Malavan , Poon Ian , Louie Alexander V. , Cheng Susanna Y. , Doherty Mark , Zhang Liying , Ung Yee , Cheung Patrick , Cheema Parneet K.
Published: January 2022

Background: The safety impact of radiotherapy (RT) timing relative to immune checkpoint inhibitors (ICIs) for advanced non-small-cell lung cancer (NSCLC) is unclear. We investigated if RT within 14 days (Interval 1) and 90 days (Interval 2) of ICI use is associated with toxicities compared to RT outside these intervals. Methods: Advanced NSCLC patients treated with both RT and ICIs were reviewed. Toxicities were graded as per CTCAE v4.0 and attributed to either ICIs or RT by clinicians. Associations between RT timing and Grade ≥2 toxicities were analyzed using logistic regression models adjusted for patient, disease, and treatment factors (α = 0.05). Results: Sixty-four patients were identified. Twenty received RT within Interval 1 and 40 within Interval 2. There were 20 Grade ≥2 toxicities in 18 (28%) patients; pneumonitis (6) and nausea (2) were most prevalent. One treatment-related death (immune encephalitis) was observed. Rates of patients with Grade ≥2 toxicities were 35%/25% in the group with/without RT within Interval 1 and 30%/25% in the group with/without RT within Interval 2. No significant association between RT timing relative to ICI use period and Grade ≥2 toxicities was observed. Conclusion: Albeit limited by the small sample size, the result suggested that pausing ICIs around RT use may not be necessary.
Reusing Grey Water to Lower Temperatures in the Mediterranean Basin Cities
Authors: Maggiotto Giuseppe
Published: January 2022

The Mediterranean region is a hot spot for climate change, and cities of this area will be exposed to both increasing temperatures and decreasing precipitations. Green Infrastructures (GIs) can lower urban temperatures through evapotranspiration with an adequate soil moisture content. Grey water reuse can both guarantee the right soil moisture content and reduce freshwater exploitation. In order to test the effectiveness of soil moisture on reducing air temperature, two modelling simulations ran with the microclimate CFD-based model ENVI-met 4.0. The chosen day was a registered heat wave (7 July 2019) in Lecce, a city of south Italy, which was selected as case study for the Mediterranean area. The results demonstrated the effectiveness of soil moisture on evapotranspiration in reducing air temperature. From a circular economy perspective, the supply of grey water for urban GIs represents a strategic adaptation strategy to the expected effects of climate change on the Mediterranean basin.