bluuebunny/crossref_metadata_2025 huggingface dataset:
Microvesicles derived from human umbilical cord mesenchymal stem cells enhance alveolar development and attenuate lung inflammation in a rat model of bronchopulmonary dysplasia induced by antenatal lipopolysaccharide
Authors: Zhou Ou , You Jingyi , Xu Xiaochuan , Liu Jiang , Qiu Huijun , Hao Chang , Zou Wenjing , Wu Wenjie , Fu Zhou , Tian Daiyin , Zou Lin
Published: January 2022

Although it is known that exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) alleviate hyperoxic lung injury of bronchopulmonary dysplasia (BPD) in animal models, the role of microvesicles (MVs) derived from hUCMSCs in BPD is poorly defined. Furthermore, antenatal inflammation has been linked to high risk of BPD in preterm infants. The purpose of this study was to explore whether MVs derived from hUCMSCs can preserve lung structure and function in an antenatal lipopolysaccharide (LPS)-induced BPD rat model and to clarify the underlying mechanism. We demonstrate that antenatal LPS induced alveolar simplification, altered lung function, and dysregulated pulmonary vasculature. Both hUCMSCs and MVs successfully promoted alveolar development and improved lung function. However, hUCMSCs but not MVs restored the loss of pulmonary microvascular vessels (<100 μm). Furthermore, MVs were mostly uptaken by alveolar epithelial type II cells (AT2) and macrophages. Compared with the LPS-exposed group, MVs restored the AT2 cell number and SP-C expression in vivo and promoted the proliferation of AT2 cells in vitro. MVs also restored the level of IL-6 and IL-10 in lung homogenate. Additionally, upregulated expression of p-AKT, downregulated expression of PTEN, as well as inhibition of MAPK pathway were observed in MVs-treated BPD rats. Taken together, this study suggests MVs derived from hUCMSCs improve lung architecture and function in an antenatal LPS-induced BPD rat model by promoting AT2 cell proliferation and attenuate lung inflammation; thus, MVs provide a promising therapeutic vehicle for BPD treatment.
Stratifin indicates worse prognosis and promotes hepatocellular carcinoma proliferation, migration, invasion and EMT by modulating Wnt/β-catenin pathway
Authors: Ye Shanping , Li Taiyuan , Shi Jun , Cheng Xiaoye
Published: January 2022

Purpose: Stratifin (SFN) is closely related to the development of cancers, but the biological role and mechanism of SFN in hepatocellular carcinoma (HCC) remain largely unknown and its function in Wnt/β-catenin/EMT pathway in HCC is currently unclear. Methods: Protein and mRNA expression levels of SFN were detected in HCC and corresponding adjacent non-tumor tissues by western blot and RT-qPCR. The correlation of clinicopathological features and SFN was analyzed. The univariate and multivariate analysis were performed to investigate the prognosis value of SFN in HCC patients based on online database. Artificial modulation of SFN was conducted to explore the role of SFN on HCC cells’ proliferation, migration, invasion in vitro, tumor growth in vivo, epithelial mesenchymal transformation (EMT) and activation of Wnt/β-catenin signaling. Results: SFN was up-regulated in HCC cell lines and tissues. Clinically, SFN was positively associated with tumor size, degree of differentiation, TNM stage and vascular invasion. Patients with high SFN levels had worse OS and DFS. Biologically, knockdown of SFN repressed tumor cell proliferation, migration, invasion in vitro and tumor growth in vivo. Conversely, over-expression of SFN promoted these effects. Mechanistically, SFN induced EMT and activated Wnt/β-catenin pathway, while depletion of SFN inhibited EMT and activation of Wnt/β-catenin pathway. Conclusions: SFN indicates worse survival in HCC patients and promotes HCC cells’ proliferation, migration and invasion. Mechanistically, SFN induces EMT by activating Wnt/β-catenin pathway. Our results clarify the role and potential mechanism of SFN in HCC, which may provide a prognostic factor and therapeutic target for HCC patients.
Transcription Analysis of Chicken Embryo Fibroblast Cells Infected with a Recombinant Avian Leukosis Virus Isolate GX14FF03
Authors: Wang Peikun , Li Qiuhong , Wang Jing , Deng Qiaomu , Li Min , Wei Ping
Published: January 2022

Infection with recombinant avian leukosis virus (ALV) has previously been linked to malignancies and immunosuppression. However, the processes behind recombinant ALV's unique pathophysiology are poorly understood. The study aims to investigate the gene expression patterns of a recombinant ALV isolate GX14FF03 infected chicken fibroblast cells (CEFs) and used the RNA-Sequence technique to undertake a complete analysis of the mRNAs transcriped. As a consequence, a total of 907 significant differentially expressed genes (SDEGs) were identified. Among these SDEGs, the most significantly up-regulated gene was interleukin 8-like 1 (IL8L1), while the most significantly down-regulated gene was fibroblast growth factor 16 (FGF16). The 907 SDGEs were highly enriched (p < 0.05) for 252 Gene Ontology (GO) terms, including 197 BP, 3 CC, and 52 MF. According to the KEGG data analysis, SDEGs are implicated in eight significant pathways (p < 0.05). Furthermore, PPI network analyses revealed that IL8L1 interacts with 17 genes. These findings provide light on the molecular mechanisms of the recombinant ALV infection by explaining the mRNA expression profile in CEFs infected with GX14FF03 virus.
Outcomes in terms of morbidity and mortality among elderly head injury patients on pre-injury anticoagulation: A systematic review protocol
Authors: Ogbu Ikenna Idika
Published: January 2022

Background: The global burden of traumatic brain injuries continues to remain grossly underestimated and is thought to cost about US$400 billion annually. Elderly individuals have the highest age-specific rates of TBIs and are more likely to take anticoagulant medication than other age groups and are therefore theoretically at a higher risk of morbidity and mortality following head injuries. However, the evidence for these worse outcomes is at best unclear, and this has a significant impact on decision-making in clinical settings, sometimes resulting in unnecessary delays to treatment.Methods: This protocol has been developed using the PRISMA-P guidelines. We will search the main clinical indexing databases (including PubMed/MEDLINE, EMBASE, Cochrane reviews, and ClinicalTrials.gov) for studies that evaluated outcomes in terms of morbidity and mortality among anticoagulated individuals aged over 65, to identify all English language studies published between the years 2000 and 2021. The identified studies will then be screened using pre-determined eligibility criteria detailed in the body of this work. Finally, two independent reviewers will screen, select, evaluate the included studies for quality, and extract data related to the use of anticoagulants in the elderly from all relevant sources. A logically sound analytic framework will then be employed to determine the impact of the use of anticoagulation on outcomes as outlined. Discussion: This study aims to identify the existing evidence for outcomes in this population, contribute to the current body of knowledge, and provide more explicit guidance for clinical practice. We envisage that the findings surrounding outcomes in the head-injured, anticoagulated elderly population will guide clinicians towards better decision-making in both the in-patient and out-patient setting and contribute to the development of clinical guidelines. Systematic review registration: This systematic review is registered on the PROSPERO database with registration number: CRD42021220974
Identifying and addressing conflicting results across multiple discordant systematic reviews on the same question: Protocol for a replication study of the Jadad algorithm
Authors: Lunny Carole , Thirugnanasampanthar Sai Surabi , Kanji Salman , Ferri Nicola , Pieper Dawid , Whitelaw Sera , Thabet Pierre , Tasmin Sara , Nelson Harrison , Reid Emma , Zhang Jia He (Janet) , Kalkat Banveer , Chi Yuan , Thompson Jacqueline Y , Abdoulrezzak Reema , Zheng Di Wen (Wendy) , Pangka Lindy R.S. , Wang Dian (Xin Ran) , Safavi Parisa , Sooch Anmol , Kang Kevin T. , Tricco Andrea C
Published: January 2022

Introduction: An increasing growth of systematic reviews (SRs) presents notable challenges for decision-makers seeking to answer clinical questions. In 1997, an algorithm was created by Jadad to assess discordance in results across SRs on the same question. Our study aims to (a) replicate assessments done in a sample of studies using the Jadad algorithm to determine if the same SR would have been chosen, (b) evaluate the Jadad algorithm in terms of utility, efficiency, and comprehensiveness, and (c) describe how authors address discordance in results across multiple SRs. Methods and Analysis: We will use a database of 1218 overviews (2000-2020) created from a bibliometric study as the basis of our search for studies assessing discordance (called Discordant Reviews). This bibliometric study searched MEDLINE (Ovid), Epistemonikos, and Cochrane Database of Systematic Reviews for overviews. We will include any study using Jadad (1997) or another method to assess discordance. The first 30 studies screened at the full-text stage by two independent reviewers will be included. We will replicate the authors’ Jadad assessments. We will compare our outcomes qualitatively and evaluate the differences between our Jadad assessment of discordance and the authors’ assessment. Ethics and Dissemination: No ethics approval was required as no human subjects were involved. In addition to publishing in an open-access journal, we will disseminate evidence summaries through formal and informal conferences, academic websites, and across social media platforms. This is the first study to comprehensively evaluate and replicate Jadad algorithm assessments of discordance across multiple SRs.
Development of a Nanoformulation for Oral Protein Administration: Characterization and Preclinical Orofacial Antinociceptive Effect
Authors: Damasceno Marina de Barros Mamede Vidal , Santos Sacha Aubrey Alves Rodrigues , Araújo João Ronielly Campêlo , Barroso Lana Karine Vasconcelos , Benevides Samara Casemiro , Magalhães Francisco Ernani Alves , Tavares Kaio César Simiano , Moreira Renato de Azevedo , Monteiro-Moreira Ana Cristina de Oliveira , Silva Angelo Roncalli Alves e , Campos Adriana Rolim
Published: January 2022

Nanoencapsulation is a valid alternative for the oral administration of peptide drugs and proteins, as nanoparticles protect them from proteolytic degradation in the gastrointestinal tract and promote the absorption of these macromolecules. The orofacial antinociceptive effect of frutalin (FTL), through the intraperitoneal route, has already been proven. This study aimed to develop, characterize, and evaluate the orofacial antinociceptive activity of an oral formulation containing FTL in acute and neuropathic preclinical tests. The analyzed sample did not show any cytotoxicity; 52.2% of the FTL was encapsulated, the size of the nanocapsules was less than 200 nm, the polydispersion was 0.361 and the zeta potential was - 5.87 millivolts. Nanoencapsulated FTL administered by oral route had an orofacial antinociceptive effect in acute and neuropathic rodent models. The antinociceptive effect of FTL was prevented by ruthenium red, but not by camphor. FTL reduced Trpv1 gene expression. FTL promotes orofacial antinociception probably due to the antagonism of TRPV1 channels and the nanoformulation represents an effective method of administering this protein orally.
Geometry and topology tango in ordered and amorphous chiral matter
Authors: Guzmán Marcelo , Bartolo Denis , Carpentier David
Published: January 2022

Systems as diverse as mechanical structures and photonic metamaterials enjoy a common geometrical feature: a sublattice or chiral symmetry first introduced to characterize electronic insulators. We show how a real-space observable, the chiral polarization, distinguishes chiral insulators from one another and resolve long-standing ambiguities in the very concept of their bulk-boundary correspondence. We use it to lay out generic geometrical rules to engineer topologically distinct phases, and design zero-energy topological boundary modes in both crystalline and amorphous metamaterials.
Is gender diversity good for the quality of accruals in Indonesia?
Authors: Robiyanto Robiyanto , Lako Andreas , Ika Rahutami Angelina
Published: January 2022

There is no regulation in emerging markets, i.e. Indonesia imposing the gender diversity quota. Therefore, based on the different characteristics and attributes between developed and emerging markets, this study aims to analyze the impact of the boardroom’s gender diversity on the quality of accruals, i.e. earnings in big Indonesian firms. This study used a sample of 100 big manufacturing firms in Indonesia. Moreover, this paper utilized a widely used proxy for the quality of earnings and the boardroom’s gender diversity. Data panel with fixed effect method was used to compute the quality of accruals while path analysis was utilized for hypotheses testing. Furthermore, the results showed evidence that the boardroom’s gender diversity indirectly influenced the quality of accruals through cash flow variability. However, the presence of female directors is not a significant inducement for managers to report better quality of earnings. The managerial implication of this study is that the boardroom’s gender diversity is good for the emerging markets since it supports better accounting accruals indirectly. Future studies should incorporate many industries and consider the potential of endogeneity, which has not been tackled in this paper.
Prediction of the Ball Location on the 2D Plane in Football Using Optical Tracking Data
Authors: AMİRLİ Anar , ALEMDAR Hande
Published: January 2022

Tracking the ball location is essential for automated game analysis in complex ball-centered team sports such as football. However, it has always been a challenge for image processing-based techniques because the players and other factors often occlude the view of the ball. This study proposes an automated machine learning-based method for predicting the ball location from players' behavior on the pitch. The model has been built by processing spatial information of players acquired from optical tracking data. Optical tracking data include samples from 300 matches of the 2017-2018 season of the Turkish Football Federation's Super League. We use neural networks to predict the ball location in 2D axes. The average coefficient of determination of the ball tracking model on the test set both for the x-axis and the y-axis is accordingly 79% and 92%, where the mean absolute error is 7.56 meters for the x-axis and 5.01 meters for the y-axis.
Handwritten Digit Recognition With Machine Learning Algorithms
Authors: DEMİRKAYA Kübra Gülgün , ÇAVUŞOĞLU Ünal
Published: January 2022

Nowadays, the scope of machine learning and deep learning studies is increasing day by day. Handwriting recognition is one of the examples in daily life for this field of work. Data storage in digital media is a method that almost everyone is using nowadays. At the same time, it has become a necessity for people to store their notes in digital media and even take notes directly in the digital environment. As a solution to this need, applications have been developed that can recognize numbers, characters, and even text from handwriting using machine learning and deep learning algorithms. Moreover, these applications can recognize numbers, characters, and text from handwriting and convert them into visual characters. This project, investigated the performance comparison of machine learning algorithms commonly used in handwriting recognition applications and which of them are more efficient. As a result of the study, the accuracy was 98.66% with artificial neural network, 99.45% with convolutional neural network, 97.05% with K-NN, 83.57% with Naive Bayes, 97.71% with support vector machine and 88.34% with decision tree. This study also developed a handwriting recognition system for numbers similar to these mentioned applications. A desktop application interface was developed for end users to show the instant performance of some of these algorithms and allow them to experience the handwriting recognition system.
Determination of Chopped Fruits Freshness with High Accuracy by Using Electronic Nose
Authors: TOZLU Bilge Han
Published: January 2022

In this study, the effect of evaporator pinch point temperature difference (∆TPP,e) value in Organic Rankine Cycle (ORC) on system performance was determined. Under different applications of ORC, optimum ∆TPP,e value has been determined in ORC systems designed with different heat source temperatures. By changing the ∆TPP,e value, the heat input provided to the system, the mass flow of organic fluid, the evaporation pressure and the enthalpy drop in the turbine are affected. In thermodynamic optimization, the objective function is determined as turbine power maximization. Genetic algorithm optimization technique is used. Within the scope of low and high temperature ORC applications, the optimum ∆TPP,e value of different organic fluids under 10 different heat source temperatures (Low, 90-130 °C; High, 250-290 °C) has been determined. Low temperature organic fluids have been selected from dry, isentropic, wet and new-generation categories. High temperature organic fluids have been selected from the alkane, aromatic hydrocarbon, and siloxane categories. The effect of ∆TPP,e on fluids of different categories was determined for low and high temperature ORCs. It has been determined that taking the ∆TPP,e value constant regardless of the heat source temperature and organic fluid causes performance loss in ORC.
Strength and vibration analysis of transonic compressor under multiple field loads
Authors: Feng Yu Ru , Wang Jun Li , Li Jin Yang
Published: January 2022

The transonic axial flow compressor Rotor 37 is subjected to the combined action of thermal load, centrifugal load, and aerodynamic load in real work. The difference in load will cause the blade deformation and the size and distribution of stress to change. And it will cause the vibration frequency of the blade to change compared with the static state at room temperature. This paper studies the compressor blades based on the fluid-thermal-structure coupling method, and comprehensively considers the combined effects of thermal load, centrifugal load and aerodynamic load on the compressor blades. The results of the study show: that when the thermal load acts on the blade alone, it will have less impact on the blade deformation and greater impact on the stress, but when coupled with other loads, it will have a greater impact on the blade deformation and stress. In the case of fluid-thermal-structure coupling, the deformation of the compressor blade will first increase and then decrease with the increase of mass flow, and the change of stress will not decrease with the increase of mass flow. Rotation speed will affect the change trend of blade stress with mass flow. Compared with the static state at room temperature, the natural frequency of the blade under fluid-thermal-structure coupling has undergone a huge change. The first-order vibration frequency has increased by 25.77 %. It can be seen from the Campbell diagram that the compressor blade has a resonance at about 63 % and 98 % Point, in this case, the blade is prone to resonance, and more attention should be paid.
Evaluation and projection of a snow coverage rate over the Upper Yarkant River Basin, China
Authors: Wei Renjuan , Peng Liang , Wu Yuxin , Liang Chuan , Zhao Lu
Published: January 2022

Based on snow coverage remote sensing data NOAA, the simulation ability of the snow coverage rate from the core experiments of the 5th Coupled Model Intercomparison Project (CMIP5) over the Upper Yarkant River Basin was evaluated. The ensemble mean of the eight models was used to project future changes in the snow coverage rate over the basin under the three different representative concentration pathways (RCP2.6, RCP4.5 and RCP8.5). The results show that the snow coverage rate of the eight models can basically simulate a sharp drop of the spatial distribution from the west to the northeast; all the eight models have the capacity to simulate the snow coverage rate of the Yarkant River Basin analyzed from the correlation analysis (R), the ratio of spatial standard deviation (SDR) and the S index. The simulation capacity of the eight models in spring, autumn and winter is stronger than the one in summer, and the ensemble mean of the eight models simulates the best. Under the scenarios of RCP2.6 and RCP4.5, changes in the snow coverage rate show negative differences in most areas over the basin, only the local part shows positive differences. Under the scenario of RCP8.5, changes in the snow coverage rate in all seasons present negative differences in the whole basin, and the decreasing trends are more obvious. Under the same emission scenario, the negative differences in winter are weaker than those of other seasons, and the most significant negative difference appears in spring and autumn. The projection scenarios indicate a clearly decreasing trend under the different emission scenarios. Under the scenario of RCP2.6, the decreasing trend is not obvious as it fails the 90% confidence level test. Under the scenarios of RCP4.5 and RCP8.5, the decreasing trend of the snow coverage rate is significant, passing the 99% confidence level test.
Investigating streamflow variability and hydroclimatic teleconnections: a comparison of regulated and unregulated streamflow stations
Authors: Pant Tarun , Ganapathy Abinesh , Agarwal Ankit
Published: January 2022

This study evaluates the relationship between flow variability of unregulated and regulated streamflow stations and global climate indicators. Mann–Kendall and change-point analysis is applied to investigate the gradual and abrupt changes in streamflow data, followed by the investigation of multi-scale fluctuations in streamflow data using Continuous Wavelet Analysis. Linkages between streamflow and global climate indicators are examined using Cross-Wavelet and Wavelet Coherence Analysis. Results showed contrasting trend values for unregulated and regulated streamflow stations. Surprisingly, all unregulated stations experienced a significant abrupt shift in change point contrary to the regulated streamflow. Further, for unregulated stations, streamflow variability and hydroclimatic teleconnections were observed at a lower scale, indicating that variations in streamflow are more frequent and generally occur on an intra-annual to inter-annual scale. Contrary to this, regulated stations observed the streamflow variability and hydroclimatic teleconnections at a larger scale (8–10 years), indicating that all the fluctuations are smoothed out. Thus, unregulated stations cannot be used as a proxy for regulated stations in any given basin. Indeed, for better water resource planning and management, both regulated and unregulated streamflow should be investigated.
Experimental study on the water–rock interaction mechanism in a groundwater heat pump reinjection process
Authors: Yang Jie , Tao Yuezan , Gao Yulan , Wang Lijuan , Kang Bo
Published: January 2022

Groundwater heat pump (GWHP) is a clean new energy technology. However, recharge clogging has always affected the operational efficiency of GWHP systems. The mechanism of the water–rock interaction inducing the chemical blockage of aquifers in particular is not clear enough. In this study, a sand column device was designed to simulate the recharge of GWHP, and the geothermal water and aquifer sand of the actual GWHP project were collected. Moreover, we have characterized the sand using SEM-EDS, XRD and FT-IR; meanwhile, the evolution of the hydrochemical components, the relationship between TDS and mineral dissolution and the concentration variation trend of [Na+ + K+] and [Mg2+ + Ca2+] were analysed. The results showed that the maximum reduction of the albite content in the column, except for P4 and P6, was 13.97%, while the calcite content in the P3–P4 and P7–P10 segments increased by 1.2%. The anhydrite content was reduced in the whole interval. Therefore, the precipitation and dissolution of minerals might occur in the process of recharge, which was more significant in the front of the column. In addition, the water–rock reaction induced by GWHP recharge is a process that also involves the cation exchange adsorption of Na+ with Mg2+ and Ca2+.
A scientometric study on quantitative microbial risk assessment in water quality analysis across 6 years (2016–2021)
Authors: Nyika Joan , Dinka Megersa
Published: January 2022

Water contamination by microbes is a growing environmental challenge that has exacerbated the apparent scarcity of safe drinking water. To alleviate this challenge, it is important to screen water for pathogens to reduce the risk of contracting waterborne diseases among consumers. The use of the quantitative microbial risk assessment (QMRA) tool to approximate illness possibility from exposure to microorganisms using dose–response models between pathogens and their associated health impacts is, therefore, recommended. The aim of this study was to explore the use of QMRA in water quality assessment using a scientometric approach and data sourced from the Web of Science (WoS) database for the period between 2016 and 2021. Articles were searched in the WoS databases before downloading the content for a bibliometric analysis using the VOSviewer software. Additionally, Microsoft Excel was used to analyze the inter-relationships of the searched results. Journal articles had the highest results from the searched query at 90.6% compared to other forms of output. High-impact journals such as the Science of the Total Environment and Water Research had the highest number of publications at 11.056 and 7.5%, respectively. Keyword analysis showed the multidisciplinary nature of the search query based on the clustered themes. The USA and China showed greater publication output with a total of 51.7% of total publications compared to developing countries due to their high research potential and extensive collaborative networks. A similar trend was evident in the institutional analysis with the University of California, USA, and the Chinese Academy of Sciences being the highest research contributors with 8% of the searched output. The study highlighted the need to extend research inputs to developing countries of Africa and Asia to improve their research and development capacity, productivity and share knowledge on QMRA in water quality assessment.
Environmental and social consequences for moving beyond archaic legislation and policy: delay and disjoint in water governance, Malawi
Authors: Chunga Brighton A. , Kusi-Appiah Andy , Masangano Clement , Mwamsamali Oswald K.
Published: January 2022

As in many sub-Saharan African countries with increasing demand for natural resources, how to move from archaic water legislation to new and up-to-date policies that cover both environmental and social consequences of water governance has become an issue. This study reviews Malawi's current governance framework and recommends a framework that takes Malawi's developmental needs into account. Our review of the state of water legislation shows that there is a lack of enforcement of the policies themselves and the public is not even aware of its existence. Lack of enforcement and public awareness have resulted in environmental degradation which is creating a lot of environmental problems for the citizens of Malawi. This work recommends future efforts in rationale evidence-based policy and legislation review that involves and is supported by multiple stakeholders. We also recommend the need for routine policy and legislation reviews in order to take advantage of cutting-edge solutions to water management issues. This will not only enhance general awareness of key environmental policies and legislation but benefit from coordinated efforts from various players to arrest the ongoing environmental degradation resulting from an incoherent policy and apathy from Malawians.
Pronoun beta and ose in Moluccas Malay
Authors: Kopong Richard , Imbang Djeinnie , Tulung Golda J. , Pamantung Rina P.
Published: January 2022

Moluccas Malay is generally spoken in Moluccas and North Moluccas Provinces. However, every place in those provinces has its own different vocabulary usage of the language like in Tanimbar Archipelago Regency. One of the differences can be seen by the usage of pronouns, especially the first person singular beta and the second person singular ose. In Tanimbar, beta is usually changed to saya and sa, while ose is usually changed to kau, engko, itrana, and itwata. In another place like Ambon, ose is sometimes changed to ale. In addition to regional differences, different situations also affect changes in the use of the two pronouns. This is analyzed by using the acronym SPEAKING in anthropological linguistics to be able to find out the speech situation such as place, time, speaker and addressee, purpose, act sequence of the speech, and others. Research data were collected using observation, interview, and documentation techniques which were then analyzed using data reduction, data display, and data conclusion. The results showed that the rules for using the pronouns beta and ose depend on different situations such as in the family when meeting new people, differences in age, gender, social groups.
A concepção da morte na filosofia cristã Português
Authors: Costa Roberto Marques
Published: January 2022

IThe article's reflection is based on the deductive hypothetical critical method. A basic, strategic, descriptive,and qualitative bibliographical research aims to critically analyze the results on theissue of death from the perspective of Christian existentialist philosophy. The credibility of the article is based on the assertion that death is, without a doubt, a research object of great relevance to scientific knowledge, because it is inherent and inseparable from human existence. In Christian existentialism, death is understood as the end of everything, but the end is understood as a goal reached and the beginning of a new life. As Leonardo Boff says: «death is the place of the true birth of man»,since every death recalls a birth. Death, therefore, is not the annihilation and reduction of the human being to absolute nothingness, but the transformation of his entire being. The source of the research is secondary and based on the idea of thinkers who reflected on death not from a philosophical-nihilistic point of view, but who made a reflection from a transcendental philosophy.
Virtual exchange: a promising high-impact practice for developing intercultural effectiveness across disciplines
Authors: Commander Nannette Evans , Schloer Wolfgang F. , Cushing Sara T.
Published: January 2022

Virtual Exchange (VE), a pedagogy that uses technology to facilitate online, collaborative work among students and their peers in other countries, is viewed as a high-impact practice contributing to engaged learning and student success in higher education. This study investigates the impact of various types of VE on the intercultural effectiveness skills of undergraduate and graduate students enrolled in courses across disciplines. The relationship between VE and intercultural skills for minority and non-minority students was also investigated, along with the relationship between dosage (length and duration) of VE and intercultural skills. Results indicate VE positively impacts the development of intercultural skills of students and that there were no differences when the data are disaggregated by individual classes or disciplinary areas. There were no significant differences for minority and non-minority students and for the impact of dosage, but further research is recommended for these two important topics. Findings of this study underline the generalizability of VE across disciplines and its suitability for providing wider access to international experiences for all students.
Understanding Engagement and the Potential Impact of an Electronic Drug Repository: Multi-Methods Study
Authors: Soobiah Charlene , Phung Michelle , Tadrous Mina , Jamieson Trevor , Bhatia R Sacha , Desveaux Laura
Published: January 2022

Background

Centralized drug repositories can reduce adverse events and inappropriate prescriptions by enabling access to dispensed medication data at the point of care; however, how they achieve this goal is largely unknown.

Objective

This study aims to understand the perceived clinical value; the barriers to and enablers of adoption; and the clinician groups for which a provincial, centralized drug repository may provide the most benefit.

Methods

A mixed methods approach, including a web-based survey and semistructured interviews, was used. Participants were clinicians (eg, nurses, physicians, and pharmacists) in Ontario who were eligible to use the digital health drug repository (DHDR), irrespective of actual use. Survey data were ranked on a 7-point adjectival scale and analyzed using descriptive statistics, and interviews were analyzed using qualitative descriptions.

Results

Of the 161 survey respondents, only 40 (24.8%) actively used the DHDR. Perceptions of the utility of the DHDR were neutral (mean scores ranged from 4.11 to 4.76). Of the 75.2% (121/161) who did not use the DHDR, 97.5% (118/121) rated access to medication information (eg, dose, strength, and frequency) as important. Reasons for not using the DHDR included the cumbersome access process and the perception that available data were incomplete or inaccurate. Of the 33 interviews completed, 26 (79%) were active DHDR users. The DHDR was a satisfactory source of secondary information; however, the absence of medication instructions and prescribed medications (which were not dispensed) limited its ability to provide a comprehensive profile to meaningfully support clinical decision-making.

Conclusions

Digital drug repositories must be adjusted to align with the clinician’s needs to provide value. Ensuring integration with point-of-care systems, comprehensive clinical data, and streamlined onboarding processes would optimize clinically meaningful use. The electronic provision of accessible drug information to providers across health care settings has the potential to improve efficiency and reduce medication errors.
US budget impact analysis of esketamine nasal spray in major depressive disorder with acute suicidal ideation/behavior
Authors: Voelker Jennifer , Sheehan John J , Le Hoa H , Toro-Diaz Hector , Li Shujun , Joshi Kruti
Published: January 2022

Background:
Esketamine nasal spray plus an oral antidepressant is approved in adults with major depressive disorder with acute suicidal ideation or behavior (MDSI).
Methods:
A budget impact analysis from a US payer perspective was performed with a hypothetical 1-million-member plan, using pharmacy and medical costs associated with adding esketamine plus an oral antidepressant to usual care.
Results:
Estimated annual total healthcare costs of managing patients with MDSI increased from $32,988,247 without esketamine to $34,161,188 in Year 3 with esketamine (primarily due to medical costs). The per-member-per-month incremental costs were $0.02, $0.06 and $0.10 in Years 1, 2 and 3, respectively.
Conclusion:
Incorporation of esketamine results in a modest estimated impact on the annual budget over a 3-year time horizon.
A Review on Healthcare Services Using Dual Chatbots as Conversational Agents
Authors: Niranjana Dr. G.
Published: January 2022

Abstract: A chat bot is an AI tool that interprets information provided by humans and responds accordingly. It is used to carry out tasks like mimic human behavior. Many of the chat bot conversations between humans and machines are repetitive. Instead of just talking to one another, a chat bot can communicate with the outside world by analyzing the user's needs and actions. Having a chat bot assistant that can help users complete their tasks makes them feel like they're doing something right. It eliminates the user's need to do the work for them. This idea has been proposed to introduce a dual-agent system that will allow users to interact with the chat bot without leaving the human interaction. It can make decisions on behalf of the user, which reduces the user's efforts in carrying out a task. This concept is demonstrated in our study. The concept is to create a chat bot that can diagnose a health issue & provide basic information before reaching out to a doctor.
Ultrasonic Blind Stick with GPS and GSM Tracking
Authors: Awasthi Astitva
Published: January 2022

Abstract: In this project we are proposing to create a model which will act as a boon for the visually impaired people in our society. This study is trying to work over a hypothetical idea of a walking stick that would alert the visually challenged people on encountering an obstacle, holes and water in their vicinity which would help in preventing any kind of accidental injury to them while walking. The project visualizes the idea of a revolutionary navigation tool for the visually impaired people. This ordinary looking blind stick is actually extra ordinary it has been provided with different kind of sensors to give the person an idea about the vicinity in which he or she is present and make the individual much more aware. The GPS sensor has been designed and programmed in such a manner that is it is able to give an idea about the best possible route depending upon the location it is able to access. The user has been provided with the phenomenal feature of choosing locations from the set of destinations that have been stored in the database of the system. In this stick ultrasonic sensor GPS and GSM tracker, ESP 8266, water sensor, infrared sensor and RF sensor, battery have been used. the comprehensive goal of the device is to provide a much more comfortable and Secure method for the visually impaired people to overcome hindrances in daily life. Keywords: GPS and GSM tracker, ESP8266, Relay, Sensor, Obstacle Detection, Wi-Fi module
SÍNTESE TEÓRICA PARA A ANÁLISE DO DESENVOLVIMENTO TERRITORIAL
Authors: Fernandes Vinícius Rodrigues Vieira , De Jesus Clesio Marcelino
Published: January 2022

O enfoque territorial, ao longo das décadas, tem sido enaltecido por cientistas, governos e organismos multilaterais como uma relevante estratégia para a discussão e promoção dos processos de desenvolvimento. A partir de um conjunto de elementos teóricos presentes nas noções de multiterritorialidade, instituições, capital social e visão marxista do espaço, objetiva-se, neste artigo, realizar uma síntese teórica para a análise do desenvolvimento territorial. Considerando esses elementos, demonstra-se que um processo de reterritorialização/multiterritorialização em tempos de globalização deve ser acompanhado por uma reconstrução da escala nacional e institucionalização de uma estratégia transescalar. Chama-se a atenção para o papel das instituições (formais e informais) e das estruturas de governança como mecanismos que promovem a regularidade de comportamentos. Enfatiza-se essa importância ao destacar que determinadas características da organização social, condensadas no conceito de capital social, facilitam a coordenação de ações entre os agentes. A partir da perspectiva marxista, destaca-se que a análise do desenvolvimento territorial pressupõe a disputa pelos espaços locais, o papel do Estado e a tentativa de anular o espaço pelo tempo. No limiar das possibilidades e dos limites, conclui-se que a abordagem territorial exige que o Estado nacional desça a cada nível das distintas escalas, interligando-as em um projeto nacional de desenvolvimento. Exige, também, a construção de pactos territoriais entre Estado e sociedade civil.
EFEITO DA INFRAESTRUTURA DAS ESCOLAS ESTADUAIS DA REGIÃO METROPOLITANA DO CARIRI NAS NOTAS DE PROFICIÊNCIA DO SPAECE NO PERÍODO DE 2008 A 2015
Authors: Lucena Manoel Alexandre de , Sousa Eliane Pinheiro de
Published: January 2022

Para avaliar as competências dos alunos nos exames de português e matemática, o estado do Ceará realiza o Sistema de Avaliação Permanente da Educação Básica (SPAECE). Tais avaliações são relevantes ao apontar fatores que influenciam a educação, como é o caso da infraestrutura física das unidades escolares. Neste contexto, o objetivo deste estudo é mensurar o efeito da infraestrutura das escolas estaduais da Região Metropolitana do Cariri (RMC) nas notas de proficiência do SPAECE do primeiro ano do ensino médio no período de 2008 a 2015. Para tal, aplicou-se um modelo de regressão de dados em painel com efeitos fixos. Essa modelagem é caracterizada pela combinação de séries temporais e dados de corte transversal. Os resultados revelaram que a presença de refeitório, laboratório de ciências, internet banda larga, auditório e área verde influenciam de forma positiva as notas de proficiência em português, enquanto o desempenho em matemática é afetado positivamente pela existência de refeitório, diretoria e internet banda larga. Portanto, torna-se necessária implementar políticas adequadas, que promovam equidade entre os insumos escolares, uma vez que a infraestrutura adequada cumpre seu papel primordial na formação do discente, de modo a reduzir as desigualdades econômicas e sociais.
Antioxidant Activity Test of Acetone and Ethanol Extracts of Cocoa (Theobroma cacao L.) Beans Husk
Authors: Pandjo Siti S. K. , Mustapa Kasmudin , Ningsih Purnama
Published: January 2022

Cocoa beans husk is waste produced from the cocoa processing industry containing alkaloid, flavonoid, tannin, saponin, and triterpenoid compounds. This material has the potential to be used as a source of natural antioxidant compounds. This study aimed to determine the antioxidant activity of cacao beans husk extracts by comparing acetone and ethanol as solvents through the extraction process. This antioxidant activity was determined using the DPPH (1,1-diphenyl-2-picrylhydrazyl) test method measured by UV-Vis spectrophotometer after adding an extract of cocoa beans husk. The positive control was vitamin C, while the negative control was DPPH solution dissolved in ethanol. The results showed that the extract of cacao beans husk has more potent antioxidant activity with a lower IC50 value of 181.2 ppm, while the acetone extract has an IC50 value of 247.9 ppm
Developing Senior High School Student’s Chemical Literacy Skills Through Inquiry-Based Online Chemistry Learning
Authors: Zebua Elly Albert , Sinaga Kelly
Published: January 2022

This paper is motivated by the challenges of chemistry class during the online learning period in developing students’ chemical literacy skills that were found during internship two by the author at a school in North Sulawesi at Senior High School. Based on these activities, it is known that the limitations of students in understanding chemical materials and concepts during online learning pose as a challenge for teachers to carry out the chemistry lessons long distanced. This paper aims to review the development of students’ literacy skills through inquiry-based learning. This paper also aims to examine the implications of chemical literacy in helping Christian teachers guide students to God's wisdom through inquiry-based chemistry’s online learning. The results from this study showed that the chemical literacy skills of students in the school where the author carried out field experience program two activities showed positive results; however, it was not comprehensive. Furthermore, chemical literacy helped Christian teachers observe students’ development in understanding chemical concepts and their relevance to biblical principles. This study concluded that honing chemical literacy skills through inquiry-based online learning can help students be more active in obtaining information. Good chemical literacy skills will help students make decisions based on problems that are always based on biblical principles. The author of this study suggests examining strategies in addition to inquiry-based learning, which can improve student’s chemical literacy skills, especially in online chemistry learning.
Identification Chemical Compositions of Lemongrass Plant (Cymbopogon nardus L.) Dawan Tribe, Oenenu Village, North Central Timor Regency
Authors: Obenu Noviana , Edi Eduardus , Adu Risna E.
Published: January 2022

Lemongrass (Cymbopogon nardus L.) is a local natural resource used by the Dawan tribe as an alternative for mosquito repellent. The utilization of these plants cannot be separated from the content of compounds found in these plants. Therefore, it is necessary to analyze the content of bioactive compounds from lemongrass (Cymbopogon nardus L.). This research method includes sample preparation, isolation and identification of compounds, and antioxidant activity analysis. The results of this study that there were three main components of citronella oil, namely geraniol, citronellol, and citronellal, with a higher percentage of geraniol, namely 18.82%. The compounds contained in lemongrass oil have a weak antioxidant activity with IC50 681.48 mg/mL.
Conceptual Changes of Students in Thermodynamics in Physical Chemistry Course Through The Implementation of Blended Learning
Authors: Afadil Afadil , Rahmawati Sitti , Suherman Suherman
Published: January 2022

This study aims to determine the conceptual changes of students after participating in learning with a blended learning approach on Thermodynamics material. This research is a type of pre-experimental (pre-experimental design) with a One Group Pretest-Postest Design. The blended learning approach is applied using the Problem Based Learning model. The research sample was Class C Odd Semester 2019/2020 students which consisted of 34 students who programmed Physical Chemistry courses. The instrument used is a two-tier multiple choice test which includes concepts in Thermodynamics material which is equipped with a valid CRI. The blended learning approach is one approach that can be used that facilitates student activities in utilizing ICT through the delivery of materials, discussion of task completion, and training in the search for teaching materials on Thermodynamics material. The results showed that misconceptions still occur in every concept of Thermodynamics. The average reduction of misconceptions (MC) is 11.2%, the increase in the number of students to knowing concept (KC) classically is 19.2%, and the decrease in the number of students unknowing concept (UKC) is classically 8.1%. Students' conceptual changes to the material of Thermodynamics are still low. Students are required to understand well the content of the material related to basic concepts, mathematical equations (formulas), and the applicative forms of concepts in everyday life in accordance with the characteristics of the thermodynamic material.
Analysis of Lycopene Content and Antioxidant Activity Test of Katokkon Chili Extract (Capsicum chinense Jacq)
Authors: Maddo Febryna V. , Aminah Siti , Afadil Afadil
Published: January 2022

This study aimed to determine lycopene contents and the antioxidant activity of katokkon chili extract. The extraction process of katokkon chili used the maceration method with the mixture of n-hexane : acetone : ethanol (2:1:1). The concentrated extract of katokkon chili was obtained through the evaporator process at a temperature of 40 ˚C. The analysis process used a UV-Vis spectrophotometer in which the absorbance reading was at λ = 472 nm. The average content of lycopene in katokkon chili extract was 1.457 mg/100g. Testing the antioxidant activity of katokkon chili extract used the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with positive control the vitamin C. The absorbance readings for the antioxidant activity test were at λ = 517 nm. The test results showed that the antioxidant power of katokkon and vitamin C extracts in reducing DPPH free radicals had a similar result which was equally strong. The IC50 value for chili katokkon extract was 13.84 mg/L, and the IC50 value for vitamin C was 5.78 mg/L, so it can be concluded that chili katokkon can be an alternative source of natural antioxidants to replace vitamin C.