bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro expansion affects the response of human bone marrow stromal cells to irradiation
Authors: Xiang Yang , Wu Chun , Wu Jiang , Quan Weili , Cheng Chao , Zhou Jian , Chen Li , Xiang Lixin , Li Fengjie , Zhang Kebin , Ran Qian , Zhang Yi , Li Zhongjun
Published: March 2019

Background

Bone marrow stromal cells (BMSCs) are extensively used in regeneration therapy and cytology experiments simulate how BMSCs respond to radiation. Due to the small number and the heterogeneity of primary isolated BMSCs, extensive in vitro expansion is usually required before application, which affects the cellular characteristics and gene expression of BMSCs. However, whether the radiation response of BMSCs changes during in vitro expansion is unclear.

Methods

In this study, BMSCs were passaged in vitro and irradiated at passage 6 (P6) and passage 10 (P10).

Then, apoptosis, the cell cycle, senescence, the cytokine secretion and the gene expression profile were analysed for the P6, P10, and non-irradiated (control) BMSCs at different post-irradiation time points.

Results

The P6 BMSCs had a lower percentage of apoptotic cells than the P10 BMSCs at 24 and 48 h post-irradiation but not compared to that of the controls at 2 and 8 h post-irradiation.

The P6 BMSCs had a lower percentage of cells in S phase and a higher percentage in G1 phase than the P10 BMSCs at 2 and 8 h post-irradiation. The radiation had similar effects on the senescent cell level and impaired immunomodulation capacity of the P6 and P10 BMSCs. Regardless of whether they were irradiated, the P6 and P10 BMSCs always expressed a distinctive set of genes. The upregulated genes were enriched in pathways including the cell cycle, DNA replication and oocyte meiosis.

Then, a subset of conserved irradiation response genes across the BMSCs was identified, comprising 12 differentially upregulated genes and 5 differentially downregulated genes.

These genes were especially associated with the p53 signaling pathway, DNA damage and DNA repair. Furthermore, validation experiments revealed that the mRNA and protein levels of these conserved genes were different between the P6 and P10 BMSCs after irradiation. Weighted gene co-expression network analysis supported these findings and further revealed the effects of cell passage on the irradiation response in BMSCs.

Conclusion

The results indicated that cell passage in vitro affected the irradiation response of BMSCs via molecular mechanisms that mediated differences in apoptosis, the cell cycle, senescence and the cytokine secretion. Thus, accurate cell passage information is not only important for transplantation therapy but also for future studies on the radiation response in BMSCs.
A genetic risk score to personalize prostate cancer screening, applied to population data.
Authors: Huynh-Le Minh-Phuong , Fan Chun Chieh , Parsons J Kellogg , Donovan Jenny , Neal David , Martin Richard , Mills Ian G , Andreassen Ole A , Dale Anders M , Seibert Tyler M ,   The PRACTICAL Consortium
Published: March 2019

181

Background: Genetic risk stratification may inform the decision of whether—and at what age—a man should undergo prostate cancer (PCa) screening. We previously validated a polygenic hazard score (PHS) for accurate prediction of age of onset of aggressive PCa and for improved screening PSA performance. The PHS is a weighted sum of 54 SNP genotypes. Here, we applied the PHS to population data to assess its potential impact on individualized screening. Methods: Age-specific PCa incidence data were obtained for men aged 40-70 years from the United Kingdom (Cancer Research UK, 2013-2015) and fit to an exponential curve as a continuous model of age-specific PCa incidence. Using hazard ratios estimated from ProtecT study data, annualized incidence rate curves were calculated for the following percentiles of genetic risk: 1, 5, 20, 50, 80, 95, and 99. The proportion of incidence classified as aggressive (Gleason score ≥7) was estimated as 59.7%, the reported result from the CAP trial. PHS was combined with incidence data to give a risk-equivalent age, when a man with given PHS percentile will have the same risk of aggressive PCa as that of a typical man at age 50 years. Results: The age-specific incidence rate of PCa for the UK population was modeled as: 0.004 e0.203(age-40) ( R2 = 0.957, p = 0.001). Table shows risk-equivalent age for each genetic risk percentile. For example, a man with a PHS in the 95th percentile reached PCa risk equivalent to a typical 50-year-old man at age 44 years; conversely, a man with a PHS in the first percentile does not reach this risk level until age 60 years. Initiation of screening discussions could be adjusted accordingly. Conclusions: PHS may inform PCa screening with individualized estimates of risk-equivalent age for aggressive PCa. Risk-equivalent age for aggressive prostate cancer, by PHS percentile. [Table: see text]
Complications from percutaneous microwave ablation of liver tumours: a pictorial review
Authors: Fang Cheng , Cortis Kelvin , Yusuf Gibran T , Gregory Stephen , Lewis Dylan , Kane Pauline , Peddu Praveen
Published: March 2019

Percutaneous microwave ablation of liver tumours is a well-established technique that has been proven to be effective in the curative and palliative treatment of small volume primary and secondary liver tumours. Microwave ablation is designed to achieve larger areas of necrosis compared to radiofrequency ablation and has a good safety profile among liver tumour treatments. Mortality is unreported and major complications are rare. Knowledge of potential complications is essential for interventional radiologists performing liver ablation in order to reduce patient morbidity. The aim of this review is to illustrate major complications post microwave ablation in a pictorial format as well as a discussion on how best to avoid these complications
Imaging appearance on CT post laparoscopic Roux-en-Y gastric bypass using bioabsorbable prosthesis with ﬁbrin glue ﬁxation to prevent a Petersen’s space hernia
Authors: Page Mark , Drummond James , Magdy Mark , Vedelago John , Kuzinkovas Vytauras
Published: March 2019

Imaging post bariatric surgery is becoming more common over the past decade due to increasing incidence of obesity in the population and subsequent treatment.

In recent years, the use of topical haemostatic agents and bioabsorbable prostheses has increased leading to higher likelihood of encountering these agents on post-operative imaging. Imaging in the post-operative period is occasionally performed to assess for complications such as obstruction, leak and abscess formation. Familiarity with these agents is crucial in preventing incorrect diagnosis.

Laparoscopic Roux-en-Y gastric bypass (RYGB) is favoured over the open approach as it is safer and more effective, with a mortality rate of 0.5% and morbidity around 7–14 %. The main cause of late post-RYGB complications is the development of internal hernias such as a Petersen’s hernia. During the procedure, a space between the alimentary loop of the small bowel and the transverse mesocolon is created and is called the Petersen’s defect. Subsequently, a part of the small bowel can herniate through this orifice. As this operation is becoming more common, the incidence of internal herniation has been increasing.

This case report describes a new bariatric surgical technique and the associated post-operative radiological appearances on CT. The surgical technique has been pioneered in Sydney, Australia and involves a laparoscopic RYGB using bioabsorbable prosthesis with ﬁbrin glue ﬁxation to prevent a Petersen’s space hernia.
Density artefacts at interfaces caused by multiple time-step effects in molecular dynamics simulations
Authors: Sidler Dominik , Lehner Marc , Frasch Simon , Cristófol-Clough Michael , Riniker Sereina
Published: March 2019

Background: Molecular dynamics (MD) simulations have become an important tool to provide insight into molecular processes involving biomolecules such as proteins, DNA, carbohydrates and membranes. As these processes cover a wide range of time scales, multiple time-step integration methods are often employed to increase the speed of MD simulations. For example, in the twin-range (TR) scheme, the nonbonded forces within the long-range cutoff are split into a short-range contribution updated every time step (inner time step) and a less frequently updated mid-range contribution (outer time step). The presence of different time steps can, however, cause numerical artefacts.

Methods: The effects of multiple time-step algorithms at interfaces between polar and apolar media are investigated with MD simulations. Such interfaces occur with biological membranes or proteins in solution.

Results: In this work, it is shown that the TR splitting of the nonbonded forces leads to artificial density increases at interfaces for weak coupling and Nosé-Hoover (chain) thermostats. It is further shown that integration with an impulse-wise reversible reference system propagation algorithm (RESPA) only shifts the occurrence of density artefacts towards larger outer time steps. Using a single-range (SR) treatment of the nonbonded interactions or a stochastic dynamics thermostat, on the other hand, resolves the density issue for pairlist-update periods of up to 40 fs.

Conclusion: TR schemes are not advisable to use in combination with weak coupling or Nosé-Hoover (chain) thermostats due to the occurrence of significant numerical artifacts at interfaces.
Determination of ceftriaxone in human plasma using liquid chromatography–tandem mass spectrometry
Authors: Wongchang Thamrong , Winterberg Markus , Tarning Joel , Sriboonvorakul Natthida , Muangnoicharoen Sant , Blessborn Daniel
Published: March 2019

Ceftriaxone is a cephalosporin antibiotic drug used as first-line treatment for several bacterial diseases. Ceftriaxone belongs to the third generation of antibiotics and is available as an intramuscular or intravenous injection. Previously published pharmacokinetic studies have mainly used high-performance liquid chromatography coupled with ultraviolet detection (HPLC-UV) for the quantification of ceftriaxone. This study aimed to develop and validate a bioanalytical method for the quantification of ceftriaxone in human plasma using liquid chromatography followed by tandem mass spectrometry (LC-MS/MS). Sample preparation was performed by protein precipitation in combination with phospholipid-removal techniques for cleaning up matrix interferences. The chromatographic separation was performed on an Agilent Zorbax Eclipse Plus C18 column with 10 mM ammonium formate containing 2% formic acid: acetonitrile as mobile phase at a flow rate of 0.4 ml/min. Both the analyte and cefotaxime (internal standard) were quantified using the positive electrospray ionization (ESI) mode and selected reaction monitoring (SRM) for the precursor-product ion transitions m/z 555.0→396.1 for ceftriaxone and 456.0→324.0 for cefotaxime. The method was validated over the concentration range of 1.01-200 μg/ml. Calibration response showed good linearity (correlation coefficient > 0.99) and no significant matrix effects were observed. The intra-assay and inter-assay precision were less than 5% and 10%, respectively, and therefore well within standard regulatory acceptance criterion of ±15%.
Parents' experiences of diagnosis and care following the birth of a child with cleft lip and/or palate
Authors: Costa Bruna , Williams Jennifer R , Martindale Anna , Stock Nicola M ,   The VTCT Foundation Research Team
Published: March 2019

Background

Receiving the news that their child has a health condition, such as a cleft lip and/or palate (CL/P), can have a considerable psychological impact on parents, yet research has highlighted parental dissatisfaction and service-related issues.

Aims

To investigate the experiences of parents of children born with CL/P in relation to postnatal diagnosis and neonatal care.

Method

Data were collected from 470 parents using an online mixed-methods survey.

Findings

The majority of participants received their diagnosis and postnatal care from a midwife. Many (61%) were satisfied with their overall diagnostic experience; however, participants also perceived a lack of sensitivity, knowledge and empathy from hospital staff. Further issues were raised regarding the implications of a ‘delayed’ diagnosis including feeding difficulties.

Conclusion

Better training and support for midwives is recommended to address the challenges associated with the postnatal diagnosis and neonatal care of children with CL/P.
The assessment of instability in the osteoarthritic knee
Authors: Wallace David T. , Riches Philip E. , Picard Frédéric
Published: March 2019

Patient-reported instability is a common complaint amongst those with knee arthritis. Much research has examined the assessment of self-reported instability in the knee; however, no definitive quantitative measure of instability has been developed. This review focuses on the current literature investigating the nature of self-reported instability in the arthritic knee and discusses the possibilities of further investigation.

Cite this article: EFORT Open Rev 2019;4:70-76. DOI: 10.1302/2058-5241.4.170079
Silastic replacement of the first metatarsophalangeal joint: historical evolution, modern concepts and a systematic review of the literature
Authors: Majeed Haroon
Published: March 2019

Silastic implants for the first metatarsophalangeal joint (MTPJ) have been in use for over 50 years. Initial reports were associated with high failure rates leading to development of new designs that are currently in use. The aim of this article is to review the historical evolution and the outcomes of silastic implants for the treatment of end-stage OA of the first MTPJ. Databases were searched for studies reporting the outcomes of silastic implants for the first MTPJ. Various relevant search terminologies were used. Studies reporting the outcomes of metallic implants or arthrodesis were excluded. The literature search revealed 522 studies, of which 28 were included. Eight studies used single-stemmed implants and 20 used double-stemmed implants for their patients. Twenty-eight studies had a total of 2354 feet with silastic replacements in 1884 patients (1968 to 2003) with an average age of 53 years and the average follow-up was 85.3 months. There were a total of 5.3% (124 feet) failed prostheses. Improvement in pain was reported in 76.6% (1804 feet) with an average patient satisfaction rate of 84%. Radiological changes around the implants were found to be significantly higher with single-stemmed implants (30.3%) compared to the double-stemmed implants (14.7%) (p < 0.05). Significantly more single-stemmed implants failed (11%) than the double-stemmed implants (3.6%) (p < 0.05). Despite the initial reports of failed implants and complications, first- and second-generation silastic implants were associated with high patient satisfaction and pain improvement. Current literature lacks long-term outcomes of implants currently in use.

Cite this article: EFORT Open Rev 2019;4:77-84. DOI: 10.1302/2058-5241.4.180055
Violence: how it forms us and how we can be self-critical about it // العنف وممارسات النقد الذاتي
Authors: Alison James
Published: March 2019

This article examines the value of René Girard's thoughts concerning the relationship between violence and the sacred for those involved in any kind of violence. It analyses the
three essential dimensions of the Girardian insight, including the mimetic nature of desire, the working of the scapegoat mechanism in the process of humanization, and the
prophetic critique of sacrifice. Against the common misapprehensions about Girard's thought with regard to its falsifiability and ideological totality, this article proposes that
Girardian thought could serve as a as resource for self-criticism for those involved in contexts of violence. The article outlines various moments of this process: heartbreak,
including the realization of sameness instead of difference; truthfulness, or the slow process of exiting mendacity; the losing of an addiction to cheap meaning; and finally the
setting free of a healthy imagination.
1968 – The Year of Living Vicariously: The London Whirlwind
Authors: Dikerdem Mehmet Ali
Published: March 2019

This is an essay in critical auto-ethnography in the form of a personal memoire of the experiences in the tumultous year 1968 of a 19-year old from a privileged but political background. Spread across London, Accra, Istanbul, Manchester and New York throughout 1968, the text is a dialogue between selected lived experiences of the time juxtaposed with retrospective political commentary trying to explain contexts, continuities and ruptures. The final section can be read as a reflection on what it means to be of the “'68 generation” half a century on.
Breaking out of panels: Formal expressions of subjectivity in Ellen Forney’s Marbles and Una’s Becoming Unbecoming
Authors: Pedri Nancy
Published: March 2019

The comics panel, many comics critics will agree, is the medium’s basic formal, structuring element. ‘Breaking out of Panels’ examines how experimentation with panel shape and frame in graphic memoir confronts readers with the subjectively felt quality of experiences, perceptions and events. In it, I propose to study not so much the placement of panels on a page, but rather their shape to ask how the use of panels in graphic memoir can serve to represent, but also multiply and fracture the outward manifestation of the protagonist’s inward, subjective vision of self. The article begins by tracing the importance of panel shape in graphic memoir, a comics genre that portrays the experiencing-I of an individual character not only across the embodiment of that character but also by way of formal stylistic devices, such as panel shape and frame. It then engages in a close examination of Ellen Forney’s Marbles: Mania, Depression, Michelangelo, and Me (2012) to detail how panel shape is used to manifest the distinction between real experience and the mental processing of that experience. Reaching the conclusion that Marbles’ experimentation with panels relays a hesitancy of perception and voice, the article addresses the unusual panel shapes and the absence of panel frames in Una’s Becoming Unbecoming. Focusing on the metaphorical meaning of the hill shape that recurs throughout the book, the article reaches the conclusion that the absence of recognizable panel shapes and frames in this graphic memoir speaks volumes to Una’s mental anguish and rage at having been the victim of sexual violence. ‘Breaking out of Panels’ concludes that both graphic memoirs experiment with panel shape and frame to express the wavering of self-knowledge, the complexity of subjectivity and elusive emotional states that impact one’s sense of self. It ends by suggesting that perhaps the comic panel can no longer be considered to be the medium’s basic unit of meaning.
An interview with Shaun Tan
Authors: Nabizadeh Golnar
Published: March 2019

Shaun Tan is a Melbourne-based artist and author, whose work is celebrated worldwide for the beautiful, dynamic, and mesmerizing story worlds that it offers readers. In 2011, Tan received the prestigious Astrid Lindgren Memorial Award in honour of his contribution to international children’s literature, and an Academy Award for the short animated film adaptation of The Lost Thing (Ruheman and Tan 2011), which he directed with Andrew Ruhemann. Tan’s work ranges from drawing and painting, to sculpture and animation, whose complex themes, and sensitive nuances resist easy classification. Instead, his sometimes surreal, playful, and evocative stories immerse readers into new and productively strange places.
Um Estudo Sociofuncionalista das Variantes Negativas Não e Num / A Socio-functionalist study of the Negative Variants "Não" and "Num"
Authors: Pereira Savanna Souza de Castro , Sousa Valéria Viana
Published: March 2019

Neste estudo investiga-se as variantes negativas não e num na oralidade, a fim de verificar quais as posições sintáticas que favorecem o uso das variantes, à luz da teoria Sociofuncionalista.  Têm-se a hipótese de que a variante não é categórica em contextos de respostas isoladas e em posição pós-verbal, entretanto, nas posições pré-verbal e dupla negação ocorrem à alternância entre o não e num. Sobre os fatores independentes sociais, acredita-se que o sexo masculino lidera o processo de variação linguística da negação em relação às mulheres. Os dados analisados nesta pesquisa foram retirados dos Corpora Português Popular e Culto de Vitória da Conquista, e submetidas à análise quantitativa. Em suma, nos resultados obtidos verificou-se que a posição pré-verbal favorece tanto a variante negativa não quanto a reduzida, num. Quanto ao fator extralinguístico sexo constatou-se que as mulheres estão propagando a variante reduzida, num, contrariando, assim, a hipótese inicial.
Teoria do Foco Regulatório: um Estudo Bibliométrico do Estado Atual da Produção Brasileira e da Relação com a Teoria dos Prospectos / Regulatory Focus Theory: a Bibliometric Study of the Current State of Brazilian Production and the Relationship with Prospect Theory
Authors: Kroth Giana Lucca , Löbler Mauri Leodir
Published: March 2019

A teoria dos prospectos trouxe muitos avanços para o entendimento do processo decisório, porém, ela assume que todas as pessoas se comportam da mesma maneira e minimiza os efeitos do sistema motivacional dos indivíduos (AINSLIE, 2016). E é neste ponto que a teoria do foco regulatório (HIGGINS, 1997) tem muito a contribuir. Segundo a teoria, existem diferentes formas de buscar sucesso/ganho e o evitar o fracasso/perda, e diferentes estratégias são utilizadas para tal. Indivíduos sob o foco de prevenção utilizam estratégias vigilantes, buscando a manutenção do status quo (não-perda), e indivíduos sob o foco de promoção utilizam estratégias agressivas, buscando o avanço do status quo (ganho). Neste contexto, o artigo apresenta um estudo bibliométrico com dois objetivos: verificar o estado atual da produção brasileira sobre a teoria do foco regulatório e estudar as relações entre as teorias do foco regulatório e dos prospectos, procurando evidências de como o cognitivo e o comportamental se complementam. Com relação ao primeiro objetivo, constata-se que os estudos brasileiros são todos muito recentes, da área de marketing e relacionados com a teoria do ajuste regulatório, deixando muito espaço para novas pesquisas. Com relação ao segundo objetivo, observa-se que, apesar de serem poucos, os estudos que fazem relação entre as teorias foram todos encontrados em periódicos internacionais e demonstram que a teoria do foco regulatório se mostra muito promissora quando associada à teoria dos prospectos, provando “ter uma contribuição muito importante na tomada de decisão de risco” (HIGGINS; CORNWELL, 2016).
Marketing Digital: A Utilização Das Mídias Sociais como um Canal de Comunicação no Varejo de Moda de Barbalha-CE / Digital Marketing: The use of Social Media as a Communication Tool in the Fashion Retail Market in Barbalha, Ceará
Authors: Saraiva Piedley Macedo
Published: March 2019

As empresas têm se aproveitado das ferramentas digitais como uma maneira de criar vínculo, estabelecer comunicação e interação de maneira direta e rápida na mensagem compartilhada com o público de interesse. O progresso das tecnologias proporcionou inúmeras maneiras de se estabelecer um espaço de diálogo e as organizações estão aprendendo sobre essas tendências e sobre as possibilidades de explorar o que as novas mídias de relacionamento prometem. Assim, este trabalho tem como tema o marketing digital, e apresenta como objeto de estudo, a utilização das mídias sociais como um canal de comunicação no varejo de moda de Barbalha-Ce. O modelo de pesquisa utilizada foi exploratório e descritiva, se utilizando ainda de um estudo de caso. Para isso, foi utilizado como instrumento para coleta de dados, entrevista estruturada com os proprietários das empresas estudadas e questionários aplicado a clientes e prospect (possíveis clientes). Quanto a análise dos dados apresentados nas entrevistas, foi percebido que a utilização do marketing digital feitos pelas empresas através das redes sociais é bastante intensa, de modo que cada um dos empreendimentos possui características reservadas de como alcançar os clientes, usufruem também essas mídias sociais para além da divulgação e captar novos clientes, obter uma possível fidelização dos mesmos.
Sexo, Sexualidade e Gênero: Memória e Efeitos de Sentido em Documentos Educacionais / Sex, Sexuality and Gender: Memory and Effects of Sense in Educational Documents
Authors: Domingues Amanda Vanele Prates , Silva Edvania Gomes da
Published: March 2019

Neste trabalho, analisamos, a partir do quadro teórico-metodológico da Análise de Discurso Francesa, de base pecheutiana, o funcionamento discursivo de documentos educacionais brasileiros, aprovados após o processo de redemocratização do país e anteriores ao Plano Nacional de Educação. Trata-se, mais especificamente, de verificar se esses documentos abordam questões relacionadas ao gênero e à sexualidade e, caso haja a presença desses termos, verificar, ainda, como eles funcionam nos textos analisados. Para tanto, selecionamos como corpus trechos de documentos que tratam de questões relacionadas à educação e aprovados entre 1996 e 2013. As análises mostraram que o campo educacional passa por constantes mudanças em relação ao tratamento/discussão de temáticas como gênero e sexualidade, desde o início da redemocratização do país, o que implica em uma flutuação nos sentidos de gênero e de sexualidade.
A atuação do Assistente Social no Centro de Referência da Assistencial Social-CRAS / The role of the Social Assistant Worker in the Reference Center for Social Assistance - CRAS
Authors: Eugenio Aparecida Vieira Souza , Gonzaga Mary Lucy De Souza
Published: March 2019

O presente artigo discorre sobre atuação do Assistente Social dentro do Centro de Referência da Assistência Social-CRAS, pautado na relevância deste profissional, visto que a maioria das demandas que chegam aos CRAS são destinadas a estes profissionais. São usuários da proteção social básica que buscam soluções para os seus problemas. O CRAS é unidade pública estatal descentralizada da política de assistência social responsável pela organização e oferta de serviço da proteção social básica do Sistema Único da assistência Social (SUAS), nas áreas de vulnerabilidade e risco social dos Municípios e Distrito Federal da sua capilaridade nos territórios e caracterizado como a principal porta de entrada do SUAS, ou seja, é unidade que possibilita o acesso de um grande número de famílias à rede de proteção social básica da assistência social.  Conclusão: A oferta dos serviços assistenciais, contribuem para a efetivação dos encaminhamentos aos aparatos sociais como: saúde, educação, geração de emprego e renda, empoderamento das famílias da proteção existente na área de abrangência próxima aos usuários.
A Gestão de Pessoas por Competência na Satisfação no Ambiente de Trabalho / The Management of People by Competence in Satisfaction in the Work Environment
Authors: Souza Nayara Amorim Coelho e , Ribeiro Luiz Guilherme Da Silva
Published: March 2019

O presente trabalho se apresenta com o objetivo de entender de que forma as mudanças que a sociedade globalizada trouxe ao mundo influenciaram mercadologicamente falando as empresas que, nos tempos atuais, precisam se adaptar para sobreviverem no competitivo mercado e, para tanto, precisam se usar de técnicas como a gestão de pessoas por competência, uma forma de entender que os funcionários da empresa são mais do que apenas um ingrediente a mais – são, em sua totalidade, parte importante da engrenagem que move a mesma e do processo de fazer com que ela se torne competitiva o suficiente para se destacar no mercado. Para tanto, é preciso que conceitos como motivação e satisfação – aqui destrinchados – sejam sempre estudados por essa técnica de gestão, para a confecção de estratégias que, dentro da estrutura organizacional, visem sempre encontrar o melhor para ambas as partes do processo. Concluiu-se que a gestão de pessoas por competência é essencial para entender o diferencial de cada funcionário e, de que forma, isso pode ser usado sempre para atingir o melhor.
KOMPLEKSITAS HUBUNGAN ANTARA WAZAN DAN MAKNA (Kajian terhadap Variasi Wazan dan Ambiguitas Bentuk Kata dalam Bahasa Arab)
Authors: Sukamta Sukamta
Published: March 2019

This paper discusses wazans, including those relating to i'lal and ibdal, in Arabic and the efforts to make the learning easier for the sake of reading the language orthography with no harakat. Wazans in Arabic are hundreds, but this paper only focuses on those related to changes in the word forms (tasrif istilahi), whose wazans of fi’il ma alone are 35. The writer classifies examples of words with the same wazan, and combines wazan ruba'i mujarrad and mazid as well as the mulhaq, as both have the same syakal. He also maps the words of the same wazan but different meaning because the sigah (the word form) is different. As to facilitate the words that have ibdal andor i'lal, the writer gives examples of such words, to be the benchmark for the search of other examples. To conclude, first is that mastery of wazans in Arabic is very important not only to read the orthography without the syakal, but also to determine the meaning of the word. Second, although a wazan determines the meaning of a word, but there is problem since the same wazan may have different meanings. Third, the knowledge of the context of the utterance will help determine the meaning of the word, and the meaning finally defines the word wazan. In other words, wazan will be determined by the meaning of the word, and vice versa, wazan and context determine the meaning of the word. Fourth, the triangle of context, meaning and wazan relate to each other and have a very important role in the process of reading and understanding texts, but not necessarily the same wazan shows the same form of words, and vice versa. This is where the complexity is.
SALAM DAN KINESIK DALAM BEBERAPA BAHASA
Authors: Ladyanna Sonezza
Published: March 2019

Greetings, along with its kineses, vary from one language to another, showing the culture of the speakers. This article discusses the system of greetings with their kineses in several languages from different continents. The research was conducted by taking into account some environmental, geographical, and socio-cultural factors of the users of the languages. The method of the research is a combination of some linguistic methods and cultural methods. The use of greetings in Indonesian, Korean, Arabic, Hungarian, Spanish, Swedish, and Swahili has a relationship with the natural state of the speakers. The greeting system in relation to the time of morning, afternoon, evening, and night can be classified into two classes. People living in areas with the time division of the morning, afternoon, evening, and night tend to use clear time-based greeting.
PUISI ANA KARYA NAZIK AL-MALA’IKAH (Analisis Semiotik Riffaterre)
Authors: Latifi Yulia Nasrul
Published: March 2019

The material object of this writing is Ana, written by Nazik al Mala’ikah, an Iraqi poet. The formal object is Riffaterre’s semiotics. In his theory, Michael Riffaterre introduces two level of reading, namely heuristic (a mimesis reading which is based upon dictionary meaning with ungrammatical characteristics) and retroactive or hermeneutic (the  decoding-process reading, which searches for a model, matrix, and hypogram for acquiring the poetic unity).  The result shows that the meaning of Ana  in heuristic reading is still spreaded, separated, and unfocused. In retroactive or hermeneutic reading, potential hypogram has shown the ide that Ana is mysterious. The Model (the poetic monumental sentence) is ‘baqaytu sahimatan huna’ and ‘abqa usa’ilu’. The Matrix is ‘the essence of human being’ on philosophical perspective. The actual hypogram, that the matrix is based on, is the existentialist thought on human being. The characteristic of this ideology is its acceptance and confession of human being as an existence. Despite his confusion, Ana> says that he is a contributor, creator, and determiner of history.
FUNGSI PINJAMAN DARI BAHASA INGGRIS DALAM TEKS BERBAHASA INDONESIA PADA RANAH OLAHRAGA
Authors: Nurweni Ari
Published: March 2019

Borrowing of different linguistic units can be encountered in almost all Indonesian texts of various domains, including sport domains. This study aims at describing the functions of borrowing from English in Indonesian texts of sport domains. The data of linguistic units borrowed from English, both loanwords and metaphorical code-switches, in Indonesian texts of sport domains were taken from the sport articles of an Indonesian national newspaper in 2010—2011, and from three sport books, each concerns with techniques of playing sports, sport education, and sport for health. The linguistic units borrowed were analyzed their pragmatic functions based on their external factors, namely, their speech components. The research results show that the linguistic units borrowed from English hold all kinds of pragmatic functions proposed by Jakobson (1973: 54—57) in the texts of sport written in Indonesian. The results imply that even though the functions expressed in the linguistic units borrowed from English are based on some reasons, not all of the functions need to be expressed in those borrowed linguistic units.
BAHASA SEKSIS DALAM KAMUS BESAR BAHASA INDONESIA
Authors: Herniti Ening
Published: March 2019

Sexist language is the language which represents men and women are not equal that one member of the group considered inferior human sex, simpler, less rights than members of the other sex. Sexist language is usually present harmful stereotypes of women. From the Indonesian vocabulary contained in KKBI found vocabulary related to gender disparities. Vocabulary is gender biased unbalanced or asymmetrical. Data captured by the technical documentation of KBBI fourth edition in 2012. With descriptive methods, data will be analyzed critically. Indonesian system actually gives equal space to both men and women. However, the development of Indonesian in a few loanwords vocabulary especially gender discrimination. Asymmetric use of language not only treats women unfairly, but also can simplify the unfair treatment of women.
ANALISIS KALKULUS PREDIKAT PADA TERJEMAHAN SURAH AL-SAFFAT
Authors: Liusti Siti Ainim
Published: March 2019

This study based on Chomsky’s generative grammar that about surface and deep structure. It is supported by Bierwish theory about projection rules, and limits choice theory by Katz and Bierwish. Predicate calculus is a study of sentence structure by relation to the componential meaning of the lexicon. Predicate calculus rests on the deep structure to form a sentence. Deep structure is able to describe such as subject, predicate, object, and others. Verb as a predicate is a core of sentence. The purposes of this research is to formulate the types of verbs and describing it  based on predicate calculus. The object of this research is some sentences of the letter translation al-S{a>ffa>t from the Holy Qur’an. There are four types of verbs are : (1) V + NP, it is commonly like V kopula + NP as variation of verb. (2) V + NP + PP, the variation of verb can be V kopula+ NP + PP. (3) V + PP, or verbs can be V kopula + PP. (4) V, without other arguments followed. It can be VP just as a verb. In addition, it is common that the PP may consist of (a) Adj + Prep, and (b) Prep + NP.
RESEPSI SASTRA NOVEL SARAH KARYA ‘ABBAS MAHMUD AL-‘AQQAD
Authors: Sukiman Uki
Published: March 2019

Sarah’s novel is a unique masterpiece of an author dubbed as Imlaq al-'Arab (The Giant), ‘Abbas Mahmud al-‘Aqqad. This novel is unique because it is the only of his work written in the form of novels among his works. It's pretty awesome because al-'Aqqad has written about 83 books in various fields of science and 10 anthologies of poetries. The presence of this novel provokes some responses of various groups of litterateurs, writers, and readers, either a positive or a negative response, particularly when it is associated with al-‘Aqqad’s side of life as well as the condition of society in his time of life. To review this novel, the author uses the Reception Theory in Literature. The theory emphasizes the reader's reception of a literary text as an important factor in the interpretation of literature. In fact, the reader as interpreter presents diversity of meaning in accordance with the Horizon of Expectations as Hans Robert Jauss said. In addition, the diversity of reader reception is also based on characters of literature itself. It always presents 'open plek' according to Walfgang Iser. It will be filled and solidified differently by the readers. The method used is the Critical Approach that aims to discuss the reception developments of review, criticism, commentary, analysis, or other forms of research such as graduating papers, theses, and dissertations. Reader’s reception toward the novel of Sarah published in1964 up to 2005 shows on three receptions feature. First, the novel is supposed as a novel presenting the women's psychological analysis. Second, Sa>rah novel is as an autobiographical novel that describes the author's love story. Third, Sarah novel is a realist novel depicting the reality of class conflict and describing the attitude of women leaders and scholars of Egypt in facing of modernization.
MASKULINITAS, KEKERASAN, DAN NEGARA DALAM THE RAID: REDEMPTION
Authors: Hidayatullah Danial
Published: March 2019

Contestation of dominant masculinity in Indonesian Popular Culture influenced by the New Order can still be seen in its cinematic production. The legacy of The New Order echoes through themes of state’s violence and masculinity. The Raid: Redemption, as a huge international success, depicting vulgar violence done both by the state and the gangsters is very important to be analyzed. As the form of collective dreams, the contestation of masculinity and violence of the state and the gangster in the movie reflects the real social condition. Through historical perspective the state and the gangster are more like binary opposition; inseparable but opposing each other. The Gangsters became the state’s Frankenstein monster. On one side the state cannot allow the crime the gangsters do, but on the other the state keeps in creating the gangsters to the dirty jobs that state cannot do. Psychoanalytically speaking, their relationship resembles a father and a bad son. Those gangsters are “the son” and the state is “the father”. The effect of the state’s treatment to the gangsters can still be identified long after the down fall of the era that created it.
STRUKTUR NARASI NOVEL SEJARAH ISLAM 17 RAMADAN
Authors: Hidayat Moh. Wakhid
Published: March 2019

17 Ramadan is a historical islamic novel by Jurji Zaidan. This is the fourth of his twenty-three historical novel. 17 Ramadan is originally published by al-Hilal newspaper. This novel tells about the events before and after the murder of Caliph Ali ibn Abi Talib on 17 Ramadan. This article presents the narrative  structure  of  the  novel  with a structural analysis of Greimas’ narrative theory. This research aims to identify the structural action with binary opposition; the sender-recipient, subject and object, and the adjuvant-obstacle. The result finds that there are four main actantial structures. These structures construct five macrostructures, those are the linear structure of revenge-action-judgement, the structure of the characters’ vindication, the linear structure of insult-thesanity-and-holy-place-chastisement, the structure with isotope of place clarification, and the structure of heroine.
MAKNA FIGURATIF SENJATA DALAM IDIOM BAHASA ARAB (KAJIAN SEMANTIK)
Authors: Sukiman Uki
Published: March 2019

This study aims to describe the meanings of idioms with weaponry elements in Arabic. The object of study is focused on the Arabic weaponry idiomatic expression. The theory of Semantic field is used to dissect the idiomatic elements. This is useful for finding relationships of meanings, which are formed by the use of elements of the weaponry idioms. The results shows that the weaponry idiomatic elements of guns have meanings mostly out of the war context. The Arabic weaponry idiomatic expression can show some positive and negative attributes, human activities and human relationships with others or with nature.
Ekokritik dalam Sastra Indonesia: Kajian Sastra yang Memihak
Authors: Dewi Novita
Published: March 2019

Literary studies of high quality require at least two things: (1) an increase on the weight and depth of appreciation of the literary works under investigation, and (2) the study’s social contribution towards the factual problems in society. The study of literature should involve the production of useful knowledge, instead of formal academic compliance. This paper is to discuss one possible type of study on Indonesian literature, i.e. ecocritical reading of literature. When examined closely through today’s politically contextual lenses and the implications thereof, Indonesian literature on environment and literary filmization can result in useful and referential knowledge. Studies of this kind differ significantly in terms of quality from a mere textual analysis of literary works with a brief, shallow description of some literary terminologies that function only as scientific embellishments. The objective of this article, therefore, is to discuss studies on Indonesian Literature using Ecocriticism as one possible trajectory to transform society.
Pyrolysis and Combustion Behavior of Pinewood After the Addition of Flame Retardants
Authors: Guo Xiujuan , Gong Xuemei , Wei Lili , Tu Qiu
Published: March 2019

To investigate the effects of flame retardants on pinewood combustion, a comprehensive analytical method has been devised based on a full description of the pyrolysis process. With the addition of ammonium polyphosphate (APP), ammonium dihydrogen phosphate (NH4H2PO4), and boric acid (H3BO3), the total amount of cellulose/hemicellulose decomposition products increased by 27.9, 63.1, and 14.2 %, respectively, and the yield of lignin-derived products decreased by 22.8, 57.7, and 13.2 %, respectively. Because of the easiest release of phosphoric acid, NH4H2PO4 had the most obvious impact on destruction of the char structure by volatiles released in the pyrolysis process, resulting in the highest peak heat release rate of 273.46 kW/m2 at a heat flux of 50 kW/m2. The addition of APP induced similar changes in the pyrolysis products, but it showed the best fire-resistance properties because of its lower surface temperature and less destruction of the char layer by volatiles. The effect of H3BO3 was weakest.
High-Temperature Cyclic Oxidation of 800H Superalloy at 750°C–950°C in Air
Authors: Emam Islam S. , Saber D. , Waheed A.
Published: March 2019

High-temperature oxidation behavior of iron-based superalloy (800H) was investigated at 750°C, 850°C, and 950°C in air for 96 h. Weight gain was used to determine the kinetics of oxidation. The surface of the alloy was characterized by using scanning electron microscopy, X-ray diffraction, and energy dispersive X-ray spectroscopy after oxidation process. The results showed that mass gain increased rapidly in the initial stage of oxidation at high temperature. The alloy obeyed parabolic behavior at 750°C, 850°C, and 950°C. The oxide layer mainly contains oxides of chromium oxide, nickel oxide, iron oxide, and spinel chromium nickel oxide. The thickness of the oxide scales increased with time and temperature.
Soundscapes of Salvation
Authors: Münz-Manor Ophir , Arentzen Thomas
Published: March 2019

We do not know how hymns in Late Antiquity sounded. We do know that refrains became an important aspect of hymnody in the period, not only among Christians in the capital accustomed to acclamations, but also among Hebrew-speaking Jews and Syriac-speaking Christians further east. This article investigates ways that the refrains contributed to shaping soundscapes or sonic space. The article constitutes a study of three of the era's most outstanding liturgical poets: Yose ben Yose and Yannai who wrote piyyutim in Hebrew and Romanos the Melodist who wrote kontakia in Greek. Refrains should ring loudly, and all three poets show a distinct awareness of the refrain's ability to shape the performative space. Throughout the song, the refrain would return repeatedly as an echo and saturate the room with loud voices. The hymnographers used this feature semantically, to dye the soundscapes with highly charged or pregnant notions, so that eventually the singing of the songs themselves gave way to the experience of community and deliverance. Conducted by poets, voices gathered to create soundscapes of salvation.
Advancing Feminism Online
Authors: Leonard Victoria , Bond Sarah E.
Published: March 2019

Can online tools address gender bias in classics? Through two case studies, this article explores the use of crowd-sourcing in order to develop digital tools that amplify women and provide them with a firmer online identity. The first, Wikipedia.org, is already entrenched in the popular research realm, and the second, WOAH (Women of Ancient History), is currently being developed as a reference tool. Wikipedia.org is the most influential source of knowledge in the world, but it has a stubborn gender bias against women. This distortion is particularly evident in the field of classics, where prior to 2017 only 7% of biographies of classicists featured women. Here, ‘classics’ is an inclusive term, and is broadly conceived to include the field of Late Antiquity. This short article details how the Women's Classical Committee (UK)'s Wikipedia editing initiative, #WCCWiki, and the development of WOAH, have successfully increased the visibility of women online. Consequently, it offers a model to mobilize change with few physical or financial resources, but rather facilitated by digital tools and social media. Through digital feminist activism, there is the potential to reverse the gender skew of classicists online and in the public discourse, while also creating an inclusive space that is professional, proactive, and accessible to all.
AIP-mutated acromegaly resistant to first-generation somatostatin analogs: long-term control with pasireotide LAR in two patients
Authors: Daly Adrian F , Rostomyan Liliya , Betea Daniela , Bonneville Jean-François , Villa Chiara , Pellegata Natalia S , Waser Beatrice , Reubi Jean-Claude , Waeber Stephan Catherine , Christ Emanuel , Beckers Albert
Published: March 2019

Acromegaly is a rare disease due to chronic excess growth hormone (GH) and IGF-1. Aryl hydrocarbon receptor interacting protein (AIP) mutations are associated with an aggressive, inheritable form of acromegaly that responds poorly to SST2-specific somatostatin analogs (SSA). The role of pasireotide, an SSA with affinity for multiple SSTs, in patients with AIP mutations has not been reported. We studied two AIP mutation positive acromegaly patients with early-onset, invasive macroadenomas and inoperable residues after neurosurgery. Patient 1 came from a FIPA kindred and had uncontrolled GH/IGF-1 throughout 10 years of octreotide/lanreotide treatment. When switched to pasireotide LAR, he rapidly experienced hormonal control which was associated with marked regression of his tumor residue. Pasireotide LAR was stopped after >10 years due to low IGF-1 and he maintained hormonal control without tumor regrowth for >18 months off pasireotide LAR. Patient 2 had a pituitary adenoma diagnosed when aged 17 that was not cured by surgery. Chronic pasireotide LAR therapy produced hormonal control and marked tumor shrinkage but control was lost when switched to octreotide. Tumor immunohistochemistry showed absent AIP and SST2 staining and positive SST5. Her AIP mutation positive sister developed a 2.5 cm follicular thyroid carcinoma aged 21 with tumoral loss of heterozygosity at the AIP locus and absent AIP staining. Patients 1 and 2 required multi-modal therapy to control diabetes. On stopping pasireotide LAR after >10 years of treatment, Patient 1’s glucose metabolism returned to baseline levels. Long-term pasireotide LAR therapy can be beneficial in some AIP mutation positive acromegaly patients that are resistant to first-generation SSA.