bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic review of the genus Ostracodinium (Ciliophora, Entodiniomorphida, Ophryoscolecidae) and notes on the taxonomy of Ostracodinium rugoloricatum Kofoid & MacLennan, 1932
Authors: CEDROLA FRANCIANE , FREGULIA PRISCILA , DA SILVA ZACARIAS ROSALINA JOÃO , ROSSI MARIANA FONSECA , MENDES SAULO MOREIRA , DIAS ROBERTO JÚNIO PEDROSO
Published: September 2021

The family Ophryoscolecidae (Ciliophora, Entodiniomorphida) constitutes a diverse and monophyletic group of symbiotic ciliates of herbivorous mammals. The family includes approximately 200 species, distributed in three subfamilies and sixteen genera. The subfamily Diplodiniinae is the most diverse group in Ophryoscolecidae and comprises the genus Ostracodinium, which includes species with two retractable ciliary zones in the anterior body portion, a broad skeletal plate covering almost all the right surface of the body and a variable number of contractile vacuoles. The genus currently comprises 28 species, classified according to body size and shape, position and shape of the nuclear apparatus, number and position of contractile vacuoles, and number and shape of caudal projections. The present study performs a systematic review of the genus Ostracodinium, based on morphological and molecular data, and provides data about geographic distribution and hosts of each species.
Pathological Level VI Lymph Node Metastasis in Clinical N3b Pyriform Sinus Squamous Cell Carcinoma
Authors: Matsui Hidetoshi , Iwae Shigemichi , Yamamura Yuta , Horichi Yuto
Published: September 2021

Objective:

The frequency of metastasis to level VI lymph nodes in advanced pyriform sinus squamous cell carcinoma (PSSCC) is unknown. We intended to analyze the clinical features and pathological presence or absence of level VI lymph node metastasis in patients with PSSCC.

Methods:

The data of 270 patients with previously untreated hypopharyngeal squamous cell carcinoma from 2006 to 2016 were obtained. Patients who underwent pharyngolaryngectomy for the pyriform sinus subsite with a curative intent with level VI dissection were included. We retrospectively analyzed the clinical Tumor-Node (TN) status (TNM classification of malignant tumors, eighth edition) and the presence or absence of pathological level VI lymph node metastasis.

Results:

A total of 34 patients were included. Eight patients (24%) had pathological level VI lymph node metastasis. The rate of pathological level VI lymph node metastasis was directly proportional to the clinical N status ( P = .0002, Chi-square test for trend). In all, 5 patients with cN2b- 3 were classified as cN3b. Ipsilateral pathological level VI lymph node metastasis was observed in 1 patient, and bilateral metastasis was observed in 3 patients. There was no association between clinical T status or pyriform sinus apex invasion and pathological level VI metastasis (both P > .99, Fisher’s exact test).

Conclusions:

PSSCC with cN3b is prone to bilateral level VI metastasis. We recommend that patients with PSSCC with cN3b should undergo bilateral level VI lymph node dissection.
Are We Reaching Everyone? A Cross-Sectional Study of Telehealth Inequity in the COVID-19 Pandemic in an Urban Academic Pediatric Primary Care Clinic
Authors: Schenker Rachel B. , Laguna Meredith C. , Odisho Anobel Y. , Okumura Megumi J. , Burnett Honora
Published: September 2021

The COVID-19 (coronavirus disease 2019) pandemic brought rapid expansion of pediatric telehealth to maintain patient access to care while decreasing COVID-19 community spread. We designed a retrospective, serial, cross-sectional study to investigate if telehealth implementation at an academic pediatric practice led to disparities in health care access. Significant differences were found in pre-COVID-19 versus during COVID-19 patient demographics. Patients seen during COVID-19 were more likely to be younger, White/Caucasian or Asian, English speaking, and have private insurance. They were less likely to be Black/African American or Latinx and request interpreters. Age was the only significant difference in patient demographics between in-person and telehealth visits during COVID-19. A multivariate regression showed older age as a significant positive predictor of having a video visit and public insurance as a significant negative predictor. Our study demonstrates telehealth disparities based on insurance existed at our clinic as did inequities in who was seen before versus during COVID-19.
Periosteal Flaps Enhance Prefabricated Engineered Bone Reparative Potential
Authors: Abu-Shahba A.G. , Wilkman T. , Kornilov R. , Adam M. , Salla K.M. , Lindén J. , Lappalainen A.K. , Björkstrand R. , Seppänen-Kaijansinkko R. , Mannerström B.
Published: September 2021

The clinical translation of bone tissue engineering for reconstructing large bone defects has not advanced without hurdles. The in vivo bioreactor (IVB) concept may therefore bridge between bone tissue engineering and reconstructive surgery by employing the patient body for prefabricating new prevascularized tissues. Ideally, IVB should minimize the need for exogenous growth factors/cells. Periosteal tissues are promising for IVB approaches to prefabricate tissue-engineered bone (TEB) flaps. However, the significance of preserving the periosteal vascular supply has not been adequately investigated. This study assessed muscle IVB with and without periosteal/pericranial grafts and flaps for prefabricating TEB flaps to reconstruct mandibular defects in sheep. The sheep ( n = 14) were allocated into 4 groups: muscle IVB (M group; nM = 3), muscle + periosteal graft (MP group; nMP = 4), muscle + periosteal flap (MVP group; nMVP = 4), and control group ( nControl = 3). In the first surgery, alloplastic bone blocks were implanted in the brachiocephalic muscle (M) with a periosteal graft (MP) or with a vascularized periosteal flap (MVP). After 9 wk, the prefabricated TEB flaps were transplanted to reconstruct a mandibular angle defect. In the control group, the defects were reconstructed by non-prevascularized bone blocks. Computed tomography (CT) scans were performed after 13 wk and after 23 wk at termination, followed by micro-CT (µCT) and histological analyses. Both CT and µCT analysis revealed enhanced new bone formation and decreased residual biomaterial volume in the MVP group compared with control and MP groups, while the M group showed less new bone formation and more residual biomaterial. The histological analysis showed that most of the newly formed bone emerged from defect edges, but larger areas of new bone islands were found in MP and MVP groups. The MVP group showed enhanced vascularization and higher biomaterial remodeling rates. The periosteal flaps boosted the reconstructive potential of the prefabricated TEB flaps. The regenerative potential of the periosteum was manifested after the transplantation into the mechanically stimulated bony defect microenvironment.
A Meta-Analysis of Factors Related to Health Information Seeking: An Integration from Six Theoretical Frameworks
Authors: Ou Mengxue , Ho Shirley S.
Published: September 2021

Prior studies have investigated the antecedents of Health Information Seeking (HIS) using different theoretical frameworks, whereas the inconsistencies in the reported findings warrant a more comprehensive synthesis of this body of knowledge. This meta-analysis identified 12 major antecedents of HIS from six widely used information seeking models examining HIS, developed an organizing framework that segmented current antecedents into cognitive, affective, sociocultural, and information carrier categories, and compared their associations with HIS by meta-analyzing 89 empirical studies ( N = 62,957). Results showed that seeking-related subjective norms and information utility yielded the strongest associations with HIS, whereas cognitive and affective factors demonstrated weaker associations with HIS. Illness types, information-seeking channels, and sampling methods significantly moderated the associations between some predictors and HIS. Implications and directions for future research were discussed.
Safety and utility of modified ultrafiltration in pediatric cardiac surgery
Authors: Palanzo David A , Wise Robert K , Woitas Karl R , Ündar Akif , Clark Joseph B , Myers John L
Published: September 2021

Introduction:

Modified ultrafiltration (MUF) is employed at the termination of cardiopulmonary bypass (CPB) in pediatric and neonatal patients undergoing congenital heart surgery to reduce the accumulation of total body water thus increasing the concentration of red blood cells and the other formed elements in the circulation. Modified ultrafiltration has been reported to remove circulating pro-inflammatory mediators that result in systemic inflammatory response syndrome (SIRS) postoperatively.

Methods:

Four hundred patients undergoing cardiac surgery requiring cardiopulmonary bypass and weighing less than or equal to 12 kg were retrospectively evaluated for the effectiveness of MUF. After the termination of CPB, blood was withdrawn through the aortic cannula and passed through a hemoconcentrator attached to the blood cardioplegia set and returned to the patient through the venous cannula. The entire CPB circuit volume in addition to the patient’s circulating blood volume were concentrated until the hematocrit value displayed on the CDI cuvette within the MUF circuit reached 45% or there was no more volume to safely remove. At the same time a full unit of FFP can be infused as water is being removed, thus maintaining euvolemia.

Results:

MUF was performed in all 400 patients with no MUF-related complications. Following the conclusion of MUF, anecdotal observations included improved surgical hemostasis, improved hemodynamic parameters, decreased transfusion requirements, and decreased ventilator times.

Conclusions:

Complete MUF enables the clinician to safely raise the post-CPB hematocrit to at least 40% while potentially removing mediators that could result in SIRS. In addition a full unit of FFP can be administered while maintaining euvolemia.
Risk factors and treatment of oxygenator high-pressure excursions during cardiopulmonary bypass
Authors: Hjärpe Anders Karl , Jeppsson Anders , Lannemyr Lukas , Lindgren Martin
Published: September 2021

Introduction:

A high-pressure excursion (HPE) is a sudden increase in oxygenator inlet pressure during cardiopulmonary bypass (CPB). The aims of this study were to identify factors associated with HPE, to describe a treatment protocol utilizing epoprostenol in severe cases, and to assess early outcome in HPE patients.

Methods:

Patients who underwent cardiac surgery with cardiopulmonary bypass at Sahlgrenska University Hospital 2016–2018 were included in a retrospective observational study. Pre- and post-operative data collected from electronic health records, local databases, and registries were compared between HPE and non-HPE patients. Factors associated with HPE were identified with logistic regression models.

Results:

In total, 2024 patients were analyzed, and 37 (1.8%) developed HPE. Large body surface area (adjusted Odds Ratio (aOR): 1.43 per 0.1 m2; 95% confidence interval (CI): 1.16–1.76, p < 0.001), higher hematocrit during CPB (aOR: 1.20 per 1%; (1.09–1.33), p < 0.001), acute surgery (aOR: 2.98; (1.26–6.62), p = 0.018), and previous stroke (aOR: 2.93; (1.03–7.20), p = 0.027) were independently associated with HPE. HPE was treated with hemodilution ( n = 29, 78.4%), and/or extra heparin ( n = 23, 62.2%), and/or epoprostenol ( n = 12, 32.4%). No oxygenator change-out was necessary. While there was no significant difference in 30-day mortality (2.7% vs 3.2%, p = 1.0), HPE was associated with a higher perioperative stroke rate (8.1% vs 1.8%, aOR 5.09 (1.17–15.57), p = 0.011).

Conclusions:

Large body surface area, high hematocrit during CPB, previous stroke and acute surgery were independently associated with HPE. A treatment protocol including epoprostenol appears to be a safe option. Perioperative stroke rate was increased in HPE patients.
Wind tunnel test on mean wind forces and peak pressure acting on ellipsoidal nacelles of wind turbine
Authors: Noda Hiroshi , Ishihara Takeshi
Published: September 2021

Mean wind forces and peak pressures acting on ellipsoidal nacelles are investigated by wind tunnel tests. The wind force coefficients of the ellipsoidal nacelles for the wind turbine design and the peak pressure coefficients for the nacelle cover design are proposed based on the experimental data. The wind force coefficients are expressed as functions of yaw angles. The proposed formulas are compared with Eurocode, Germanischer Lloyd and ASCE7-16. It is found that the mean wind force coefficients for the wind turbine nacelles are slightly underestimated in Eurocode. The equivalent maximum and minimum mean pressure coefficients are proposed for use in Design Load Case 6.1 and Design Load Case 6.2 of IEC 61400-1. The peak pressure coefficients are derived using a quasi-steady theory. The proposed equivalent maximum and minimum mean pressure coefficients are much larger than those specified in Germanischer Lloyd.
Understanding Ridesplitting Behavior with Interpretable Machine Learning Models Using Chicago Transportation Network Company Data
Authors: Abkarian Hoseb , Chen Ying , Mahmassani Hani S.
Published: September 2021

As congestion levels increase in cities, it is important to analyze people’s choices of different services provided by transportation network companies (TNCs). Using machine learning techniques in conjunction with large TNC data, this paper focuses on uncovering complex relationships underlying ridesplitting market share. A real-world dataset provided by TNCs in Chicago is used in analyzing ridesourcing trips from November 2018 to December 2019 to understand trends in the city. Aggregated origin–destination trip-level characteristics, such as mean cost, mean time, and travel time reliability, are extracted and combined with origin–destination community-level characteristics. Three tree-based algorithms are then utilized to model the market share of ridesplitting trips. The most significant factors are extracted as well as their marginal effect on ridesplitting behavior, using partial dependency plots for interpretation of the machine learning model results. The results suggest that, overall, community-level factors are as or more important than trip-level characteristics. Additionally, the percentage of White people highly affects ridesplitting market share as well as the percentage of bachelor’s degree holders and households with two people residing in them. Travel time reliability and cost variability are also deemed more important than travel time and cost savings. Finally, the potential impact of taxes, crimes, cultural differences, and comfort is discussed in driving the market share, and suggestions are presented for future research and data collection attempts.
Knowledge and Perceptions on Menstrual Hygiene Management Among School-Going Adolescent Girls in South Sudan
Authors: Atari Dominic Odwa , Tariquzzaman Sheikh K. , Nancy Andura
Published: September 2021

This article draws on grounded theory and ethnographic fieldwork approaches and applies a political ecology of adolescent health (PEAH) framework to examine how school-going adolescent girls and their communities perceive sexual and reproductive health education (SRHE) and menstrual hygiene management (MHM) in the region. Three young girls were purposefully selected from each of 10 government-run mixed primary schools in Juba, South Sudan, as peer research evaluators (PREs) and key informants ( N = 30). Each PRE interviewed and reported on three of their peers about how they talk about and manage menstruation. The findings show that political, socioeconomic, and cultural factors do influence adolescent girls’ and their communities’ perceptions about puberty and menstruation. In general, MHM was culturally constructed, but the results show a disproportionate emphasis on social norms rather than on SRHE, which could have long-lasting health implications for adolescent girls. There is a need for all stakeholders in education to come together to better grasp and address the obstacles young girls face in their communities and school environments. There is also a need to develop relevant training materials to assist care providers and adolescent girls to openly talk about and address sexual and reproductive health issues.
“They Aren’t Going to Do Jack Shit”: Text-Based Crisis Service Users’ Perceptions of Seeking Child Maltreatment-Related Support From Formal Systems
Authors: Schwab-Reese Laura M. , Cash Scottye J. , Lambert Natalie J. , Lansford Jennifer E.
Published: September 2021

Many of the children reported to child protective services (CPS) exhibit signs and symptoms that allow others to recognize their abuse or neglect and intervene; others, especially adolescents, must disclose their experiences to be identified. Relatively little is known about young people’s disclosure experiences, but individual, interpersonal, and cultural factors appear to influence when and how young people disclose. Technology-facilitated approaches, such as text- or chat-based hotlines or crisis services, may be one way to help young people share their maltreatment experiences and seek help. The current study contributes to the small body of literature that includes nonsexual maltreatment disclosures and sheds some light on how to support young people during their disclosures. We conducted a qualitative content analysis of all conversations from a text-based crisis service that resulted in a report to CPS ( n = 244). Many of the texters had previously sought support from their peers or parents, and some had engaged with more formal systems. Many young people were hesitant to reach out to formal systems in the future, in part because of negative experiences during past disclosure experiences. Young people may be more likely to seek support through their preferred communication medium, so providing text- and chat-based communication may be one way to encourage and facilitate disclosure. As these resources become increasingly available, determining best practices for receiving disclosures through technology-facilitated platforms will be critical.
Personality, Attitudinal, and Demographic Predictors of Non-consensual Dissemination of Intimate Images
Authors: Karasavva V. , Forth A.
Published: September 2021

Non-consensual intimate image dissemination (NCII), or else better known as “revenge pornography” is a form of technology-facilitated sexual violence that can have devastating effects on the victim. This is one of the first studies examining how demographic characteristics (gender, sexual orientation), personality traits (Dark Tetrad), and attitudes (aggrieved entitlement, sexual entitlement, sexual image abuse myth acceptance) predict NCII perpetration and victimization. In a sample of 810 undergraduate students (72.7% female and 23.3% male), 13.7% of the participants had at some point in their life, distributed nude, or sexual pictures of someone else without consent and 28.5% had experienced such victimization. NCII perpetration was predictive of NCII victimization and vice versa. Using binomial logistic regression, we found that women, members of the LGBQ+ community, those scoring higher in sadism, and participants with a history of NCII perpetration were more likely to report that someone had distributed their nude or sexual image without consent. Further, we found that those scoring higher in narcissism and sadism, along with those with a history of NCII victimization were more likely to report they had distributed the nude or sexual image of someone else without consent. Finally, the findings suggest that the relationship between victims and perpetrators is quite a bit more varied than the term “revenge pornography” implies.
Diagnostic and Translational Utility of the Secondary Traumatic Stress Clinical Algorithm (STS-CA)
Authors: Sprang Ginny , Whitt-Woosley Adrienne , Eslinger Jessica
Published: September 2021

Current tools available to assess secondary traumatic stress (STS) do not account for whether the symptoms are functionally related to indirect trauma, determine functional impairment caused by the STS symptoms, and/or consider the duration of the disturbance. This prevents delineation of various expressions of traumatic stress related to indirect trauma that may constitute the phenomenon of STS. The STS Clinical Algorithm (STS-CA) was developed to make these distinctions, so that interventions can be tailored to need. This study investigates the following: (1) the diagnostic concordance between the STS-CA findings and scores on the Secondary Traumatic Stress Scale (STSS); (2) reasons for diagnostic discrepancies between the STS-CA and the STSS assessments. Three trained interviewers used the STS-CA to guide the determination of clinical outcome ( N = 181) in a diverse group of helping professionals. There was 100% agreement between the CAPS and the STS-CA, and fair agreement (κ =.426, p = .000) between the STS-CA and the STSS. The STS-CA demonstrated more sensitivity in classifying positive cases, and specificity in delineating those with atypical cluster presentations or little to no functional impairment that prohibited a post-traumatic stress disorder diagnosis than the STSS. Effective treatment of STS requires proper identification and the delivery of protocols that are tailored to the unique ways that STS manifests. This study provides some insights into the utility of the STS-CA in guiding this process and creates STS categories to organize and classify intervention strategies.
Improved detection of Mycobacterium tuberculosis and M. bovis in African wildlife samples using cationic peptide decontamination and mycobacterial culture supplementation
Authors: Goosen Wynand J. , Kleynhans Léanie , Kerr Tanya J. , van Helden Paul D. , Buss Peter , Warren Robin M. , Miller Michele A.
Published: September 2021

In South Africa, mycobacterial culture is regarded as the gold standard for the detection of Mycobacterium tuberculosis complex (MTBC) infection in wildlife even though it is regarded as “imperfect.” We compared a novel decontamination and mycobacterial culture technique (TiKa) to the conventional mycobacterium growth indicator tube (MGIT) system using known amounts of bacilli and clinical samples from MTBC-infected African buffaloes ( Syncerus caffer), white rhinoceros ( Ceratotherium simum), and African elephants ( Loxodonta africana). Use of the TiKa-KiC decontamination agent on samples spiked with 10,000 to 10 colony forming units (cfu) of M. bovis (SB0121) and M. tuberculosis (H37Rv) had no effect on isolate recovery in culture. In contrast, decontamination with MGIT MycoPrep resulted in no growth of M. bovis samples at concentrations < 1,000 cfu and M. tuberculosis samples < 100 cfu. Subsequently, we used the TiKa system with stored clinical samples (various lymphatic tissues) collected from wildlife and paucibacillary bronchoalveolar lavage fluid, trunk washes, and endotracheal tube washes from 3 species with known MTBC infections. Overall, MTBC recovery by culture was improved significantly ( p < 0.01) by using TiKa compared to conventional MGIT, with 54 of 57 positive specimens versus 25 of 57 positive specimens, respectively. The TiKa mycobacterial growth system appears to significantly enhance the recovery of MTBC members from tissue and paucibacillary respiratory samples collected from African buffaloes, African elephants, and white rhinoceros. Moreover, the TiKa system may improve success of MTBC culture from various sample types previously deemed unculturable from other species.
Rattlesnake envenomation in 2 Visayan warty pigs
Authors: Henderson Eileen E. , Stadler Cynthia K. , Poppenga Robert H. , Asin Ros Javier , Uzal Francisco A.
Published: September 2021

Rattlesnake envenomation is an important cause of morbidity and mortality in humans and animals in the southwestern United States and elsewhere. Two Visayan warty pigs ( Sus cebifrons) from a regional zoo were submitted for autopsy after being found dead close to a southern Pacific rattlesnake ( Crotalus helleri) in their enclosure. Both pigs had severe regionally extensive cutaneous, subcutaneous, and muscle hemorrhage and edema with myonecrosis. Additionally, both pigs had lesions consistent with puncture wounds within the oral cavity, and one pig had a similar wound on a forelimb. The history, and gross and histologic findings, were consistent with envenomation by rattlesnake bite. There are few documented cases of snakebite envenomation in pigs, and it had been suggested that pigs may have some degree of resistance to envenomation. Our results indicate that warty pigs are susceptible to the action of rattlesnake venom.
Early and Standard Urinary Catheter Removal After Gynecological Surgery for Benign Lesions: A Quasi-Experimental Study
Authors: Chen Shu Fen , Wang Peng-Hui , Kuo Shu-Chen , Chen Yin-Chen , Sia Huei-Jhen , Lee Pei-Hsuan , Yang Jia-Hwa , Kao Senyeong
Published: September 2021

Patients undergoing gynecological surgery commonly receive indwelling transurethral Foley catheters, however duration of catheterization is associated with risk of urinary tract infections and other adverse effects. Early removal of catheters is encouraged, however optimal timing postsurgery remains unclear. This quasi-experimental study compared outcomes for women after removal of a Foley catheter at two different times following benign gynecological surgery. Participants received either early catheter removal, within 6 hours of surgery ( n = 38) or standard catheter removal, within 12 to 24 hours of surgery ( n = 45). There were no significant differences in outcomes for discomfort scores or re-catheterization rates between groups. However, the early removal group had a significantly shorter time to first ambulation and shorter hospital stays. Early removal of Foley catheters in patients who underwent gynecological surgery did not increase adverse events. Early removal of catheters after gynecological surgery may decrease re-catheterization rates and increase patient satisfaction.
How Women and Men Pee: Assessing Gender-Specific Urination Practices for a Comfortable Toilet Experience
Authors: Schelbert Vasco , Kriwanek Lena , Sakthivel S. Ramesh , Kristoferitsch Lotte , Gründl Harald , Lüthi Christoph
Published: September 2021

NoMix toilets separate urine and feces at the source and are a promising resource recovery technology. However, design issues hamper the transformation from unattractive to aspirational products. Little effort has been done to design toilets that account for physiological differences, leading to adverse effects on user-friendliness and urine separation efficiency. We used infrared recordings to assess gender-specific urination practices. Based on field data, we developed the Urinator, a simple device that allows simulating male and female urine streams. This supports engineers in developing more user- and gender-friendly and reuse-oriented sanitation technologies.
Fully Intra-articular Lasso-Loop Stitch Technique for Arthroscopic Anterior Talofibular Ligament Repair
Authors: Qin Jiajun , Fu Qiang , Zhou Qing , Wu Helin , Zhi Xiaosong , Xu Feng , Cai Xianhua , Wei Shijun
Published: September 2021

Background:

Arthroscopic techniques have gradually become popular for anterior talofibular ligament (ATFL) repair. However, the reliability of the repair and the risk of nerve injuries are of concern. The aim of this study was to evaluate the fully intra-articular lasso-loop stitch technique for arthroscopic ATFL repair.

Methods:

From October 2018 to December 2019, 43 cases with chronic lateral ankle instability were treated with this fully intra-articular lasso-loop stitch technique using the Arthro-Pierce instrument. The Karlsson-Peterson score, Cumberland Ankle Instability Tool (CAIT) score, visual analog scale (VAS) score, anterior drawer and talar tilt stress fluoroscopy were evaluated at the preoperative and final follow-up appointments, respectively. All surgical complications were also recorded.

Results:

A total of 39 cases were followed up for a mean of 28.23 ± 3.64 months (range, 23-34 months). At the final follow-up, the averages of the Karlsson-Peterson, CAIT and VAS scores were 90.26 ± 6.58, 88.56 ± 7.21 and 0.79 ± 1.06, respectively. During surgery, 2 cases were modified with augmentation of the inferior extensor retinaculum. No nerve injuries were encountered. Only 1 female complained about mild knot irritation. A 25-year-old solider required revision surgery due to an accidental injury.

Conclusion:

We found the fully intra-articular lasso-loop stitch technique for ATFL repair using the Arthro-Pierce instrument to be reliable and safe with a sufficient and good-quality ligament remnant.

Level of Evidence:

Level IV, retrospective case series.
Safety Assessment of Keratin and Keratin-Derived Ingredients as Used in Cosmetics
Authors: Burnett Christina L. , Bergfeld Wilma F. , Belsito Donald V. , Hill Ronald A. , Klaassen Curtis D. , Liebler Daniel C. , Marks James G. , Shank Ronald C. , Slaga Thomas J. , Snyder Paul W. , Gill Lillian J. , Heldreth Bart
Published: September 2021

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 8 keratin-derived ingredients, which function mainly as skin and hair conditioning agents in personal care products. The Panel reviewed relevant data provided in this safety assessment and concluded that the 8 keratin-derived ingredients are safe in the present practices of use and concentration described in this safety assessment.
Safety Assessment of Saccharide Esters as Used in Cosmetics
Authors: Scott Laura N. , Bergfeld Wilma F. , Belsito Donald V. , Hill Ronald A. , Klaassen Curtis D. , Liebler Daniel C. , Marks James G. , Shank Ronald C. , Slaga Thomas J. , Snyder Paul W. , Gill Lillian J. , Heldreth Bart
Published: September 2021

This is a safety assessment of 40 saccharide ester ingredients as used in cosmetics. The saccharide esters are reported to function in cosmetics as emollients, skin-conditioning agents, fragrance ingredients, and emulsion stabilizers. The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the relevant data for these ingredients. The Panel concluded that the saccharide esters are safe in cosmetics in the present practices of use and concentrations described in this safety assessment.
Drug-Induced Seizures: Considerations for Underlying Molecular Mechanisms
Authors: Larson Erik A. , Accardi Michael V. , Zhong Yifei , Paquette Dominique , Authier Simon
Published: September 2021

A broad spectrum of chemical entities have been associated with drug-induced seizure (DIS), emphasizing the importance of this potential liability across various drug classes (e.g., antidepressants, antipsychotics, antibiotics, and analgesics among others). Despite its importance within drug safety testing, an understanding of the molecular mechanisms associated with DIS is often lacking. The etiology of DIS is understood to be a result of either a deficit in inhibitory (e.g., gamma aminobutyric acid) or an elevated excitatory (e.g., glutamate) signaling, leading to synchronous neuronal depolarization affecting various brain regions and impairing normal neurological functions. How this altered neuronal signaling occurs and how these changes interact with other non-brain receptor driven DIS-associated changes such as metabolic disturbances, electrolyte imbalances, altered drug metabolism, and withdrawal effects are poorly understood. Herein, we discuss important molecular mechanisms identified in DIS for several drugs and/or drug classes. With a better understanding of the molecular mechanisms associated with DIS, in vivo or in vitro models may be applied to characterize and mitigate DIS risk during drug development. Susceptibility stratification for DIS presents species differences in the following order beagle dogs > rodents and cynomolgus monkeys > Göttingen minipigs with a more than 2-fold difference between canines and minipigs, which is important to consider during non-clinical species selection. While clinical signs such as myoclonus, severe muscle jerks, or convulsions are often associated with abnormal epileptiform EEG activity, tremors are most of the time physiological and rarely observed with concurrent epileptiform EEG activity which need to be considered during DIS risk evaluation.
A population data-driven workflow for COVID-19 modeling and learning
Authors: Ozik Jonathan , Wozniak Justin M , Collier Nicholson , Macal Charles M , Binois Mickaël
Published: September 2021

CityCOVID is a detailed agent-based model that represents the behaviors and social interactions of 2.7 million residents of Chicago as they move between and colocate in 1.2 million distinct places, including households, schools, workplaces, and hospitals, as determined by individual hourly activity schedules and dynamic behaviors such as isolating because of symptom onset. Disease progression dynamics incorporated within each agent track transitions between possible COVID-19 disease states, based on heterogeneous agent attributes, exposure through colocation, and effects of protective behaviors of individuals on viral transmissibility. Throughout the COVID-19 epidemic, CityCOVID model outputs have been provided to city, county, and state stakeholders in response to evolving decision-making priorities, while incorporating emerging information on SARS-CoV-2 epidemiology. Here we demonstrate our efforts in integrating our high-performance epidemiological simulation model with large-scale machine learning to develop a generalizable, flexible, and performant analytical platform for planning and crisis response.
Ocular dermoids in 13 cats: a multicentre retrospective study
Authors: Cathelin Anaïs , Augsburger Anne-Sandrine , Anne Jennifer , Medan Sylvain , Michel Julien , Isard Pierre-François , Douet Jean-Yves , Dulaurent Thomas
Published: September 2021

Objectives

The aim of this multicentre retrospective study was to review the clinical data, outcomes and histopathological features of cats that had been treated for ocular surface dermoids.

Methods

Thirteen cats from various private practices in France with a clinical diagnosis of ocular surface dermoid were included in the study.

Results

The mean age of the study population at the time of diagnosis was 5 months. There were nine males and four females. Three different breeds were domestic shorthair (n = 7), Birman (n = 4) and Havana Brown (n = 2). Two of the four Birmans were related (same sire). The two Havana Browns were also related (same sire). All of the dermoids were unilateral. Five of the dermoids were strictly conjunctival. Four affected both the conjunctiva and the cornea. Three affected both the conjunctiva and the eyelid, and one was strictly corneal. They were located in various positions: temporal (n = 9), inferonasal (n = 1), dorsonasal (n = 1) and dorsotemporal (n = 1). The last dermoid was heterogeneous and involved the nasal, dorsal and temporal quadrants. Concurrent eye diseases were observed in five patients: four cats exhibited associated eyelid agenesis and one cat exhibited persistent iris-to-iris pupillary membranes. Ten dermoids were surgically excised with no recurrences. Surgery was not performed for three cats: one cat died a few days after diagnosis and two cats were lost to follow-up after initial presentation.

Conclusions and relevance

Ocular surface dermoids are a rare condition in cats that can be treated successfully by surgical excision. Although our study reports only a small number of cases, the observation of ocular surface dermoids in two related cats in two different breeds indicates that genetic transmission is likely.
Examining different outcome measures for reliability in assessing the impact of cataract surgery in quality of health
Authors: Mylona Ioanna , Aletras Vassilis , Ziakas Nikolaos , Tsinopoulos Ioannis
Published: September 2021

Introduction:

The aim of this study was to determine a reliable combination of vision-specific measures and general health measures to assess the improvement on the patient’s QoL following cataract surgery either when patients had first time surgery or had already received successful surgery in the fellow eye for cataract.

Methods:

Study sample included two waves of data measurement in 150 patients undergoing uncomplicated cataract surgery who were assessed for visual acuity, vision-specific quality of life, and general health. Data were acquired pre-surgery and 2 months post-surgery. About 90 patients haven’t had prior cataract surgery while 60 patients had prior successful cataract surgery in the fellow eye.

Results:

There was considerable improvement in all outcome measures following cataract surgery. Patients who have had prior surgery presented with modestly higher scores in the vision-specific QoL measures and minimal benefit pre-operatively compared to those who haven’t had any surgery in the general health measure. They also had more gains post-surgery in the vision-specific QoL measures only.

Conclusions:

There is a possibility that gains in QoL plateau after a certain level of visual acuity improvement. While improvement can be detected with a general health QoL measure, this measure may require additional psychometric validation to the particular population beforehand. Otherwise, a combination of vision-specific outcome measures will provide the most reliable estimate.
Work-retirement transitions and mental health: A longitudinal analysis of the role of social protection generosity in 11 countries
Authors: Sjöberg Ola
Published: September 2021

Aims:

This study aimed to analyse the effect of work-retirement transitions on post-retirement mental health in individuals with different working conditions in late working life. The focus was on transitions that involve the use of social protection schemes to bridge the gap between the exit from work and retirement, and the extent to which the generosity of such schemes is related to mental health after retirement.

Methods:

Individual-level panel data from the Survey of Health, Ageing and Retirement in Europe for 11 European countries were analysed using structural equation models. A total of 1642 individuals who worked in 2004 or 2007 and who retired in 2013 or 2015 were included in the analyses. The outcome measure was mental health as measured by the EURO-D scale.

Results:

Respondents with a ‘high strain’ and ‘passive’ work situation have a significantly higher likelihood of using social protection schemes, such as early retirement, sickness, disability and invalidity schemes before retirement. The generosity of such schemes has a significant positive relation to post-retirement mental health.

Conclusions:

This study shows that the generosity of early exit pathways is important for post-retirement mental health, especially for individuals with adverse working conditions at the end of their working lives.
Fluid-structure interactions of internal pressure pipeline using the hierarchical finite element method
Authors: Hicham Fakiri , Abdelhamid Hadjoui , Nabil Mohammed O.
Published: September 2021

We study the influence of the fluid with the structure in vibration between fluid and structure of a cylinder of circular section granted by the phenomenon of the interaction fluid structure of a conditioned flow of laminar nature and incompressible in the form of the macrostructure. These two phenomena by the mechanical relations of stresses according to displacements, modelled by a cylinder. The analysis of the vibrations of cylinders filled with fluid is studied with limiting conditions of fluid and the solid with the coupling conditioned by its limits of action-reaction in forces. The problem of the cylindrical pipe is formulated by deriving the deformation and the kinetic energies of the vibrating cylinder with and its fluid to have different natural frequencies, we use the principle of Hamilton change the problem in the expression of the equation cylindrical differential which gives three displacement functions in a system of partial differential equations of the cylindrical coordinate of circular section which meet the limiting conditions imposed at both ends. Let us apply the Navier-Stocks equation in cylindrical coordinates, with the fluid continuity equation, for the solid equation of mechanical behaviour of stresses in terms of displacement by strain. To obtain the results of natural frequencies we use the Galerkin method for solid and for Galerkin-time fluid. Where the liquid influences the inner surface of the circular cylinder, depending on the condition of the coupling that the stresses of the solid are equal to the stresses fluid. The modelling is done by a computer language (MATLAB), the hierarchical finite element method is presented by a Legendre polynomial with double integral of Rodrigues, to arrive at the final formula of the mass-rigidity matrix, which dissects on three parts (fluid, coupling and structure). Based on a comparison with experimental results. We continue to study some geometrical and physical parameters which influence the natural frequencies, in a proportional or inversely proportional way.
Rethinking attentional reset: Task sets determine the boundaries of adaptive control
Authors: Grant Lauren D , Cerpa Samantha R , Weissman Daniel H
Published: September 2021

Adaptive control processes that minimise distraction often operate in a context-specific manner. For example, they may minimise distraction from irrelevant conversations during a lecture but not in the hallway afterwards. It remains unclear, however, whether (a) salient perceptual features or (b) task sets based on such features serve as contextual boundaries for adaptive control in standard distractor-interference tasks. To distinguish between these possibilities, we manipulated whether the structure of a standard, visual distractor-interference task allowed (Experiment 1) or did not allow (Experiment 2) participants to associate salient visual features (i.e., colour patches and colour words) with different task sets. We found that changing salient visual features across consecutive trials reduced a popular measure of adaptive control in distractor-interference tasks—the congruency sequence effect (CSE)—only when the task structure allowed participants to associate these visual features with different task sets. These findings extend prior support for the task set hypothesis from somewhat atypical cross-modal tasks to a standard unimodal task. In contrast, they pose a challenge to an alternative “attentional reset” hypothesis, and related views, wherein changing salient perceptual features always results in a contextual boundary for the CSE.
Visually guided movement with increasing time-on-task: Differential effects on movement preparation and movement execution
Authors: Matuz András , van der Linden Dimitri , Zsidó András , Csathó Árpád
Published: September 2021

Top-down cognitive control seems to be sensitive to the detrimental effects of fatigue induced by time-on-task (ToT). The planning and preparation of the motor responses may be especially vulnerable to ToT. Yet, effects of ToT specific to the different phases of movements have received little attention. Therefore, in three experiments, we assessed the effect of ToT on a mouse-pointing task. In Experiment 1, there were 16 possible target positions with variable movement directions. In Experiment 2, the layout of the targets was simplified. In Experiment 3, using cuing conditions, we examined whether the effects of ToT on movement preparation and execution were caused by an increased orientation deficit or decreased phasic alertness. In each experiment, initiation of movement (preparatory phase) became slower, movement execution became faster and overall response time remained constant with increasing ToT. There was, however, no significant within-person association between the preparatory and execution phases. In Experiments 1 and 2, we found a decreasing movement time/movement error ratio, suggesting a more impulsive execution of the pointing movement. In addition, ToT was also accompanied with imprecise movement execution as indicated by the increased errors, mainly in Experiment 2. The results of Experiment 3 indicated that ToT did not induce orientation and phasic alerting deficits but rather was accompanied by decreased tonic alertness.
Data-driven group comparisons of eye fixations to dynamic stimuli
Authors: Onwuegbusi Tochukwu , Hermens Frouke , Hogue Todd
Published: September 2021

Recent advances in software and hardware have allowed eye tracking to move away from static images to more ecologically relevant video streams. The analysis of eye tracking data for such dynamic stimuli, however, is not without challenges. The frame-by-frame coding of regions of interest (ROIs) is labour-intensive and computer vision techniques to automatically code such ROIs are not yet mainstream, restricting the use of such stimuli. Combined with the more general problem of defining relevant ROIs for video frames, methods are needed that facilitate data analysis. Here, we present a first evaluation of an easy-to-implement data-driven method with the potential to address these issues. To test the new method, we examined the differences in eye movements of self-reported politically left- or right-wing leaning participants to video clips of left- and right-wing politicians. The results show that our method can accurately predict group membership on the basis of eye movement patterns, isolate video clips that best distinguish people on the political left–right spectrum, and reveal the section of each video clip with the largest group differences. Our methodology thereby aids the understanding of group differences in gaze behaviour, and the identification of critical stimuli for follow-up studies or for use in saccade diagnosis.
Controlled or automatic? Influence of congruency proportion and stimulus-onset asynchrony on the brightness-valence and spatial-valence metaphoric congruency effects
Authors: Huang Yanli , Tse Chi-Shing , Xie Jiushu , Shen Manqiong , Wang Ruiming
Published: September 2021

Whether a cognitive process is operated automatically or in a controlled manner has been a long-standing question in cognitive psychology. However, this issue has not been investigated in the activation of metaphoric association. A primed word valence judgement task is often used to test the activation of metaphoric association, in which participants first see a prime (bright/dark square or fixation point moving up or down from the centre of the screen) and then make a valence judgement to a target word. Metaphoric congruency effect occurs when participants make faster judgements to the target with valence being matched with the prime ( good followed bright/top prime) than being mismatched with the prime ( good followed dark/bottom prime). In the present two experiments, we manipulated prime-target stimulus-onset asynchrony (SOA) and proportion of metaphorically congruent trials (congruency proportion) to tease apart the effects of automatic and controlled activation of brightness-valence and spatial-valence metaphoric associations on word valence judgements. Results showed an overall effect of congruency proportion on brightness-valence and spatial-valence metaphoric congruency effect, which was independent of prime-target SOA. The effect was enhanced or reversed when congruency proportion was higher or lower than 0.5, respectively, suggesting that the activation of metaphoric association could be modulated by strategic control. The implications of these findings on the Conceptual Metaphor Theory and semantic priming theories are discussed.