bluuebunny/crossref_metadata_2025 huggingface dataset:
Omega-3 Polyunsaturate Fatty Acid Supplementation Potential to Improve Activity Components of Rheumatoid Arthritis: A Systematic Review
Authors: Hidayat Nadia , Awalia Awalia , Tambunan Betty Agustina , Novida Hermina
Published: September 2023

Introduction: Rheumatoid arthritis (RA) is a chronic disease that causes deformity in most productive age and can lead to death as disease activity increases. Omega-3 polyunsaturated fatty acids have the potential to complement available therapies in reducing disease activity. Currently, the effect of omega-3 PUFAs on disease activity components is still unclear. The current systematic reviews determine the effect of omega-3 PUFAs’ supplementation on the components of RA disease activity. Methods: This research is guided by the PRISMA guidelines systematically. Literature was searched in the databases: PubMed, MDPI, and Clinicaltrials.gov. The inclusion criteria used were: giving omega-3 PUFAs, free full-text, RCT, in English or Indonesian, assessing disease activity and its components; while the exclusion criteria were: unpublished, comparisons were inappropriate. Assessment of literature quality with the Cochrane Collaboration's tool. The study included six studies from 1994 to 2017. Results: The effect of omega-3 PUFAs is diversity in changes of disease activity in 4 of 5 studies. There are significant reductions in the number of joint pains in the literature by daily doses above 2.9 grams or at lower doses taking longer; and swollen joints in 2 studies that were only affected in doses above 2.9 grams. There are significant reductions in pain severity in the studies. Change increases with higher doses. There are variable LED and CRP changes. Conclusion: Depending on their dose and administration duration, omega-3 PUFAs can directly and indirectly affect disease activity through the influence of most of its components, namely: the number of joints affected and the degree of pain.
STUDI BIOGEOGRAFIS IKAN PUYAU (osteochilus SP) BERBASIS PROFIL PROTEIN DARI DANAU ROWO IJO, SITUS BUKIT BANGKAI
Authors: Susilo Tanto Budi , Soendjoto Mochamad Arief , Soesanto Oni , Mustaqima Raifa Azizia , Sasmita Rani , Bianchi Paola
Published: September 2023

This Bukit Bangkai would like be became a candidate for place evolution rock art heritage unit (PERAHU). In this site, the Rowo Ijo lake as a habitat, where it was found biogeographically, a Puyau fish (Osteochilus sp). Furthermore, the method of precipitation fraction of ammonium sulfate ((NH4)2SO4) with Lowry and SDS-PAGE elaboration was used, as the main method to obtain the protein profile of fish protein. Analysis of kinship relations was carried out using the UPGMA method based on the profile.. Based on the results of the fraction (NH4)2SO4 and Lowry methods, the optimum protein content was obtained, namely 68.93; 116.08; 6.72; 7.96 (mg/ml) in the 70-80% fraction and 4 samples from Banjar Regency 19.17; 16.93; 20.04; and 20.04 mg/mL in the 40-70% fraction, respectively. Based on the results of SDS-PAGE at the optimum level of protein; Puyau Rowo Ijo fish have 64 bands, with a profile of 11 bands on P.1R code, 9 bands on P.2R code, 10 bands on P.3R code and 9 bands on P.4R. For Puyau Banjar fish there are 25 bands with the following profile; each code P.1B and P.2B has 6 bands, while P.3B has 10 bands and P.4B has 3 bands. The types of proteins found were thought to include Actin Protein, Carbonic Anhydrase, Trypsin Inhibitor, -lactalbumin, and Lysozyme. The results of the UPGMA analysis based on the distribution of protein species and weights were that there was related closely to two groups form (clusters) between puyau from the Lake Rowo Ijo and Banjar Regency.
Pancreatic Neuroendocrine Tumor (P-NET) Presented by Abdominal Pain: Case Report and Literature Review
Authors: Regolo Matteo , Cardaci Nicolas , Salmeri Clara , Laudani Alfredo , Colaci Michele , Ippolito Massimo , Motta Fabio , Magrì Salvatore , Parisi Stefanie , Torcitto Alfredo Gaetano , Malatino Lorenzo
Published: September 2023

Pancreatic neuroendocrine tumor (P-NET) is a rare neoplasm originating in the neuroendocrine system. Carcinoid syndrome occurs in approximately 19% of patients with functional P-NETs, typically when liver metastases occur. NETs diagnosis is frequently late, along with symptoms related to hormone hypersecretion. We described the case of a patient with a low-grade non-functional P-NET, but with a typical clinical presentation of a carcinoid syndrome; moreover, we reviewed the literature regarding this topic. An 81-year-old male was admitted to our Department of Internal Medicine at Cannizzaro Hospital (Catania, Italy) because of the onset of abdominal pain with nausea, loose stools and episodic flushing. Firstly, an abdominal contrast-enhanced CT scan showed a small pancreatic hypervascular mass; then a gallium-68 DOTATOC integrated PET/CT revealed an elevated expression of SSTR receptors. Serum Chromogranin A and urinary 5-HIAA measurements resulted negative. Given the small size of the lesion (8 mm), we preferred to perform an endoscopic ultrasonography (EUS) with fine-needle biopsy (EUS-FNB), allowing the diagnosis of low-grade (G1) non-functional P-NET (NF-P-NET). Surgery was waived, while a follow-up strategy was chosen. Early recognition of P-NETs, although rare, is necessary to improve patient’s survival. EUS-FNB should be the protocol of choice for an early characterization of these tumors.
Application of TiS2 as an Active Material for Aqueous Calcium-Ion Batteries: Electrochemical Calcium Intercalation into TiS2 from Aqueous Solutions
Authors: Seong Sujin , Lee Hajin , Lee Sangyup , Nogales Paul Maldonado , Lee Changhee , Kim Yangsoo , Jeong Soon-Ki
Published: September 2023

This study explores the potential of titanium disulfide (TiS2) as an active material for aqueous calcium-ion batteries (CIBs). We investigate the electrochemical redox reactions of calcium ions within TiS2 and assess its suitability for use in aqueous CIBs. Additionally, we examine the im-pact of different electrolyte concentrations on TiS2 electrode reactions. Our findings reveal that TiS2 exhibits distinct charge-discharge behaviors in various aqueous calcium-ion electrolytes. Notably, at higher electrolyte concentrations, TiS2 effectively suppresses the hydrogen genera-tion reaction caused by water decomposition, demonstrating its potential as an active material for aqueous CIBs. In-situ X-ray diffraction analysis confirms the intercalation of Ca2+ ions be-tween TiS2 layers during charging. This confirmation is groundbreaking, as it represents the first experimental evidence of calcium ions being electrochemically inserted between TiS2 layers from aqueous solutions, signifying a previously unreported achievement and strongly suggesting TiS2's applicability in aqueous CIBs. X-ray photoelectron spectroscopy analysis further supports the formation of a solid electrolyte interphase (SEI) on the TiS2 electrode surface, contributing to the suppression of electrolyte decomposition reactions. Furthermore, we investigate the influ-ence of anions in the electrolyte on charge-discharge behavior. Our findings suggest that the choice of anion coordinated with Ca2+ ions affects SEI formation and cycling performance. Un-derstanding the role of anions in SEI formation is crucial for optimizing aqueous CIBs. In con-clusion, this research underscores TiS2's potential as an active material for aqueous calcium-ion batteries and emphasizes the importance of electrolyte composition in influencing SEI formation and battery performance. These findings contribute to the development of more sustainable and efficient energy storage technologies.
The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation
Authors: Roméo Bruno , Lestra Valentine , Martelli Catherine , Amirouche Ammar , Benyamina Amine , Hamdani Nora
Published: September 2023

The aim of our study was to evaluate the impact of T. gondii status on eosinophils count (PNE), eosinophil to lymphocyte ratio (ELR) and eosinophil to neutrophil to lymphocytes ratio (ENLR) before and after can-nabis cessation in patients with psychiatric disorders. One hundred and eighty-eight patients were includ-ed in the study. T. gondii, PNE, ELR, ENLR, and urinary cannabis were measured at baseline and after 4 weeks of cannabis cessation. Highest PNE (p = .02), ELR (p = .03) and ENLR levels (p = .031) and highest increase of PNE (p = .044), and ENLR (p = .036) levels were found in patients after cannabis cessation only in the Toxo+ group. At four weeks, significant interactions between cannabis and T. gondii status for PNE (p = .038), and for ENLR (p = .043) levels were found, as well as for the evolution between baseline and 4 weeks for ENLR level (p = .049). After cannabis cessation, we found a positive correlation between negative symptoms and PNE levels at 4 weeks in the Toxo+ group. This study shows that the increase of inflammation after cannabis cessation might be modulated by T. gondii seropositivity status in patient after cannabis cessation.
Beyond Human Understanding: Benchmarking Language Models for Polish Cariology Expertise
Authors: Wojcik Simona , Rulkiewicz Anna , Pruszczyk Piotr , Lisik Wojciech , Poboży Marcin , Pilchowska Iwona , Domienik-Karlowicz Justyna
Published: September 2023

The growing dependence on large language models (LLM)s highlights the urgent need to deepen trust in these technologies. Regular, rigorous validation of their expertise, especially in nuanced and intricate scenarios, is essential to ensure their readiness for clinical applications. Our study pioneers the exploration of LLM utility in the field of cardiology. We stand at the cusp of a transformative era where mature AI and LLMs, notably ChatGPT, GPT-4, and Google Bard, are poised to influence healthcare significantly. Recently, we put three available LLMs, OpenAI's ChatGPT-3.5, GPT-4.0, and Google's Bard, to the test against a significant Polish medical special-ization licensing exam (PES). The exams cover the scope of completed specialist training, focusing on diagnostic and therapeutic procedures, excluding invasive medical procedures and interven-tions. In our analysis, GPT-4 consistently outperformed the others, ranking first, with and Google Bard and ChatGPT- 3.5 following, respectively. The performance metrics underscore GPT-4's no-table potential in medical applications. Given a score improvement of over 23.5 % between two AI models released just four months apart, clinicians must stay informed and up-to-date about these rapidly evolving tools and their potential applications to clinical practice. Our results provide a snapshot of the current capabilities of these models, highlighting the nuanced performance dif-ferences when confronted with identical questions
Serotonergic Modulation of the Excitation-Inhibition Balance in the Visual Cortex
Authors: Carlos-Lima Estevão , Higa Guilherme Shigueto Vilar , Viana Felipe José Costa , Tamais Alicia Moraes , Borges Fernando da Silva , Francis-Oliveira José , De Pasquale Roberto
Published: September 2023

Serotonergic neurons constitute one of the main systems of neuromodulators, whose diffuse projections regulate the functions of the cerebral cortex. Serotonin (5-HT) is known to play a crucial role in the differential modulation of cortical activity related to behavioral contexts. Certain aspects of the 5-HT signaling framework hint at its potential role as a modulator of activity-dependent synaptic changes within the critical period of the primary visual cortex (V1). Cells of the serotonergic system are among the first neurons to differentiate and operate. During postnatal development, ramifications from raphe nuclei become massively distributed in the visual cortical area, remarkably increasing the availability of 5-HT for the regulation of excitatory and inhibitory synaptic activity. A substantial amount of evidence has demonstrated that synaptic plasticity at pyramidal neurons of the superficial layers of V1 critically depends on a fine regulation of the balance between excitation and inhibition (E/I). Therefore, 5-HT could play an important role in controlling this balance, providing the appropriate excitability conditions that favor synaptic modifications. In order to explore this possibility, the present work used in vitro intracellular electrophysiological recording techniques to study the effects of 5-HT on the E/I balance of V1 layer 2/3 neurons, during the critical period. Serotonergic modulation of the E/I balance has been analyzed on spontaneous activity, evoked synaptic responses, and long-term depression (LTD). Our results pointed out that the predominant action of 5-HT implies a reduction of the E/I balance. 5-HT promoted LTD at excitatory synapses while blocking LTD at inhibitory synaptic sites, thus shifting the Hebbian alterations of synaptic strength towards lower levels of E/I balance.
Observing Liquid Sloshing based on Multi-DOF Pendulum Model and Free Surface Fluctuation Sensor
Authors: Qi Xiaojing , Zhang Yingchao , Gao Bolin
Published: September 2023

Rollover prevention of partially-filled tank trucks is an industry teaser, with the core challenge being real-time perception and observation of the liquid state inside the tank. In order realize re-liable observation of sloshing liquid, this article firstly proposes a sloshing modeling method based on multi-degree-of-freedom pendulum model, and derives the double mass trammel pendulum model (DMTP, 2DOF) accordingly, which accurately reflects the sloshing dynamics under more pervasive working conditions. Secondly, a free surface fluctuation sensor is designed based on magnetostriction, capable of measuring the inclination and height of the liquid level inside tanks filled with hazardous chemical. Finally, the unscented Kalman filter (UKF) is utilized to synthesize the information of the two, establishing a credible real-time observation of the sloshing liquid. Verified through vehicle-fluid coupled co-simulation, under condition of con-secutive double lane change, observation error of the proposed method is only 25.9% that of the open-loop calculation, providing a secure guarantee for the observation of the state variables of the single pendulum model (SP) used for most kinds of anti-rollover controller.
Influence of Selected Lifestyle Factors on Nonylphenol Concentration in Breast Milk of Mothers in Slovakia
Authors: Repková Adriana , Mišľanová Csilla , Hrabčáková Janka , Masár Marián , Wimmerová Soňa , Žemlička Lukáš , Valachovičová Martina
Published: September 2023

Nonylphenol is a endocrine disruptors who belongs to alkyphenol groups. It´s high occurrence in the environment can caused an adverse effect on human health. The breast milk can serve as a marker to take measure of human exposure to these chemicals through different routes of exposure. In this study, the influence of different factors (including the length of accommodation, kind of wastes mothers drink, con summation of fish, pork and beef; using gloves, mail polish, using vitamins and medication) on the concentration on nonylphenol in breast milk were studied. The length of accommodation has a statistically significant effect on nonylphenol, concentration in breast milk (p value was 0.02). Other mentioned factors had not a significant influence on nonylphenol values.
Unveiling the Potential of Watermelon Rind Extract: Impact on Cell Proliferation, Apoptosis, Senescence, and Transcriptomic Profile in Human Renal Adenocarcinoma Cells
Authors: Chinreddy Subramanyam Reddy , Natarajan Purushothaman , Nimmakayala Padma , Hankins Gerald R , Reddy Umesh K.
Published: September 2023

Cancer researchers are fascinated by the chemistry of diverse natural products which show exciting potential as anticancer agents. In this study, we aimed to investigate the anticancer properties of watermelon rind extract (WRE) by examining its effects on cell proliferation, apoptosis, senescence, and global gene expression in human renal cell adenocarcinoma cells (HRAC-769-P) in vitro. Our metabolome data analysis of WRE exhibited untargeted phyto-constituents and targeted citrulline (22.29 µg/mg). HRAC-769-P cells were cultured in RPMI-1640 media and treated with 22.4, 44.8, 67.2, 88.6, 112, 134.4, and 156.8 mg mL-1 for 24, 48, and 72 hrs. At 24 hrs after treatment, (88.6 mg ml-1 of WRE) cell proliferation significantly reduced, more than 34% compared to the control. Cell viability decreased 48 and 72 hours after treatment to 45% and 37%, respectively. We also examined poly caspase, SA-beta-galactosidase (SA-beta-gal), and wound healing activities using WRE. All treatments induced an early poly caspase response and a significant reduction in cell migration. Further, we analyzed the transcript profile of the cells grown at 44.8 mg ml-1 of WRE after 6 hours using RNA sequencing (RNAseq) analysis. We identified 186 differentially expressed genes (DEGs), including 149 upregulated genes and 37 downregulated genes, in cells treated with WRE compared to the control. The differentially expressed genes were associated with NF-Kappa B signaling and TNF pathways. Crucial apoptosis-related genes such as BMF, NPTX1, NFKBIA, NFKBIE, and NFKBID might induce intrinsic and extrinsic apoptosis. Another possible mechanism is a high quantity of citrulline may lead to induction of apoptosis by the production of increased nitric oxide. Hence, our study suggests the potential anticancer properties of WRE and provides insights into its effects on cellular processes and gene expression in HRAC-769-P cells.
Deformation Pattern of Well-Preserved High-Pressure Rocks (SE Syros, Cyclades)
Authors: Gerogiannis Nikolaos , Aravadinou Eirini , Xypolias Paraskevas
Published: September 2023

New detailed geological/structural mapping as well as field-based structural analysis were carried out to investigate the deformation pattern of well-preserved high-pressure rocks of the Blueschist Unit exposed on SE Syros (Cyclades, Greece). Our new geological mapping revealed the occurrence of a metasedimentary sequence underlain by a meta-igneous sequence. The contact between these two sequences displays typically interfingering patterns in map-scale due to folding. The earlier ductile deformation phase recognized in the mapped area, is associated with the development of a penetrative foliation, which was formed under eclogite/blueschist facies conditions at peak conditions. The subsequent main deformation phase occurred at blueschist facies conditions synchronous with the early stages of exhumation of the high-pressure rocks. This phase is mainly associated with the formation of map-scale WNW-trending folds and a pervasive axial planar foliation linked with ESE-directed shearing. The main deformation ceased within blueschist facies conditions and exhumation of the rocks to greenschist facies conditions took place under very weak deformation. Greenschist retrogression observed in the southwestern part of the mapped area seems to be controlled by fluids rather than by intense deformation. Our results indicate that the high-pressure rocks of the Blueschist Unit exposed on Syros Island represent a large-scale pod of low deformation under blueschist to greenschist facies conditions, likely occupying the core of an extrusion wedge.
Modulating Matrix Metalloproteinase-9 and Enhancing Ocular Surface Health in Dry Eye Disease Patients: A Clinical Evaluation of A Topical Formulation Containing Sesquiterpene Lactone Helenalin
Authors: Ng Dalia , Altamirano-Vallejo Juan Carlos , Sanchez-Aguilar Oscar Eduardo , Inzunza Andres , Valdez-Garcia Jorge Eugenio , Gonzalez-de-la-Rosa Alejandro , Bustamante-Arias Andrés , Armendáriz-Borunda Juan , Santos Arturo
Published: September 2023

Purpose: To assess the tolerability, safety, and efficacy of an ophthalmic topical formulation containing helenalin from Arnica montana and hyaluronic acid 0.4% (HA) in patients with mild to moderate dry eye disease (DED) exhibiting positive Matrix Metalloproteinase 9 (MMP-9) test results.

Methods: Tolerability and safety were evaluated in 24 healthy subjects. Participants were in-structed to routinely apply one drop of the formulation three times a day in the study eye, for a period of two weeks, followed by a clinical follow-up of 21 days. Efficacy was studied in 48 DED patients randomized into Study (Group 1/ receiving the study formulation) or Control (Group 2/ Receiving HA 0.4% eye lubricant) groups, for 4 weeks. Assessments included MMP-9 positivity, conjunctival impression cytology (CIC), Ocular Surface Disease Index (OSDI), non-invasive tear film breakup time (NIF-BUT), non-invasive average breakup time (NIAvg-BUT), ocular surface staining, Schirmer's test, and meibomiography. A crossover design with a four-week follow-up was applied to the control group.

Results: Healthy subjects receiving the study formulation exhibited good tolerability and no ad-verse events. Group 1 showed significant MMP-9 reduction (25% positivity rate) unlike Group 2 (87.5% positivity rate). Group 1 displayed improved CIC (33.3% vs. 0% SSD) compared to Group 2 (29.1%). OSDI and NIF-BUT scores improved in both groups (p < 0.001). Only Group 1 showed improved NIAvg-BUT and Schirmer’s test scores (p < 0.001), while Group 2 did not (p > 0.05). MMP-9-positive subjects shifted from 25% to 91.6% in Group 1 and 87.5% to 20.8% in Group 2 after the follow-up.

Conclusion: The topical formulation containing helenalin from Arnica montana and hyaluronic acid is well tolerated and has a good safety profile. Our formulation reduces DED sympto-matology and modulates the ocular surface inflammatory process; this is evidenced by the en-hancement of CIC, the improvement of DED-related tear film status, and the reduction of MMP-9 positivity rate.
A Deep Learning Approach to Classify Autism Spectrum Disorder using MRI Images
Authors: Gogoi Deba Kanta , Talukdar Jyotismita , Bhattacharyya Dhruba Kumar , Singh Thipendra P
Published: September 2023

Autism Spectrum Disorder (ASD) is a neuro developmental condition that impacts social interac-tion, communication, and behavior. It is called a spectrum because its symptoms and degrees of severity can vary greatly from one person to the next. Differentiations in brain structure and function have been observed between autistic and typically developing brains. Various aspects of brain function, including information processing, sensory perception, and the capacity to interpret and respond to social cues, may be affected by these differences. The signs and symptoms of ASD are readily apparent to parents in the first few years of their child’s life. The symptoms of ASD, it is said, first appear in early childhood and continue into maturity. Brain MRI analysis utilizing deep learning methods show encouraging findings in the study of ASD. In this study, we look at how well a customized VGG16 architecture compares models that have already been trained. Inception v3, ResNet50, DenseNet121, and MobileNet are used to identify and analyze ASD problems in a brain MRI dataset from people with ASD. The proposed methods have been vali-dated on the unlabeled ABIDE 1 dataset that is freely available to the public. After the unlabeled data has been clustered, five different Deep Learning (DL) methods are used and compared. The results are compared to those of other studies that have already been conducted.
Optimization Modeling of Integrated Energy Systems considering User Response Characteristics
Authors: Yang Qiuxia , Sun Zhaoyang , Yao Siyu
Published: September 2023

Abstract: With the continuous integration of various energy systems and the reform of energy trading marketization, the traditional power demand response can no longer meet the needs of multi-energy coupling. For the joint response problem of multi-energy, this paper proposes a comprehensive demand response optimization incentive model considering the user response characteristics, with the complete energy service providers and multiple users as the participants of the comprehensive demand response, to solve the response strategy for the optimal goal of all parties. The implementation architecture of integrated demand response and the electrothermal energy hub model is introduced first. Secondly, the integrated demand response collaborative optimization strategy of the integrated energy service providers and users is established, and the existence and uniqueness of the optimal solution are proved. Finally, the example analysis demonstrates that the proposed strategy can reduce the integrated energy service providers' response cost and user dissatisfaction under multiple scenarios.
Questionable Validity of Creatinine-Based eGFR in Elderly Patients
Authors: Geißer Dario , Hetzel Lina , Westenfeld Ralf , Boege Fritz
Published: September 2023

Background: Recommended CKD first-line diagnostics is based on GFR-determination by Creatinine. Cystatin C-use may provide better assessment.
Methods: We compared creatinine- and cystatin C-derived eGFR determination in first-line di-agnostic of 112 hospital patients aged >60 years (median=76 years). Patients were judged kid-ney-sane according to first-line diagnostic recommendations (N=61, eGFR (CKD-EPI) ≥60ml/min/m2, total urine protein <150mg/g creatinine, urinary red and white blood cells not increased) or classified at-risk for kidney insufficiency due to aortic valve dysfunction (N=51). Plausibility of eGFR-values was evaluated retrospectively by final case diagnoses.
Results: eGFR (CAPA) was found linearly correlated to eGFR (CKD-EPI) (R2=0.5, slope=0.69, p<0.0001). In 93/112 (>80%) cases, eGFR (CAPA) yielded lower values (on average ≈20%). In 55/112 (49%) cases CKD-stage decreased. CKD-reclassification from kidney-sane to kid-ney-insufficient state (i.e. CKD1/2 to CKD3a/b or 4) or reclassification to more severe kidney in-sufficiency (i.e. CKD3a3b/4 or 3b4) was found in 41/112 (37%) cases. Worsening of CKD-classification (kidney-sanekidney-insufficient) based on eGFR (CAPA) was in 30% of cases plausible in the light of final case-diagnoses.
Conclusion: In elderly patients (>60 years), renal function appears systematically overestimated by creatinine-based eGFR (CKD-EPI) heralding for this group employment of cystatin C-based eGFR (CAPA) as first-line diagnostic.
Research on the Measurement of Central Bank Communication Index and its Impact on the Macroeconomy
Authors: Liao Jiayi , Zheng Jing
Published: September 2023

With the increasing size of financial assets and the complexity of monetary patterns, countries around the world are gradually becoming more transparent in their monetary policies, using central bank monetary policy communication as a new type of monetary policy instrument. To measure central bank communication more accurately, this paper proposes a dynamic topic model, LDA-BP, based on branching processes, to construct the central bank communication index. At the same time, this paper does four things: it uses the constructed communication index as a proxy variable for the new monetary policy instrument; it builds a TVP-FAVAR model that can extract potential macroeconomic information from many variables, and its time-varying nature can better reflect the dynamic regulatory effect of monetary policy; it constructs a three-dimensional impulse response diagram; and it conducts a systematic analysis of macroeconomic impact. The experimental results of demonstrate its effectiveness on central bank monetary policy communication, as it captures timely information about conventional monetary policy instruments and immediately responds to changes in interest rates and money supply. All three monetary policy instruments are effective in smoothing output volatility, with monetary policy communication having a longer-term impact on the macroeconomy.
Egy önértékelő eszköz a tanári kérdezési stratégiák elemzéséhez
Authors: Király Flóra
Published: September 2023

A tanítás-tanulás interaktív szakaszának egyik legfontosabb eleme a kérdezni tudás készsége, amellyel különböző szinten rendelkeznek a pedagógusok. A tanulmány alapját képező vizsgálat 24 tanóra tanári kérdései alapján modellezi a tanárok kérdezési stratégiáit. Bemutatja a kérdezésistratégia-elemek közötti összefüggéseket, valamint három pedagógus összesen 14 órájának az elemzésével ismerteti a tanári kérdezési stratégiák egyéni sajátosságait. A tanulmány a vizsgálat eredményei alapján módszertani javaslatokat fogalmaz meg. Emellett egy önértékelő eszköz formájában a tanári kérdezési stratégiák pedagógiai hatékonyságát befolyásoló tényezőket is bemutatja. Az eszközt mind a kezdő, mind a gyakorló tanárok használhatják tanórai kérdéseik elemzéséhez. A rendszeres és tudatos önmonitorozás által még hatékonyabbak lehetnek a kérdéseik megfogalmazásában. A tudásépítés egyik legfontosabb tanórai elemének fejlesztésével az iskolai tanulási folyamatot is eredményesebbé lehet tenni.
Tanárképzésben részt vevő hallgatók nyelvi ideológiái: a (nyelvi) másság konstruálódása
Authors: Tücsök Dorottya
Published: September 2023

A tanulmány a kritikai szociolingvisztikai keretet felhasználva vizsgálja a tanárképzésben részt vevő hallgatók és a nyelvi ideológiák kapcsolatát, a (nyelvi) másság konstruálását. A dolgozat a „Befogadó felsőoktatás: a szuperdiverzitás konstrukciói és a változó ideológiák” című Új Nemzeti Kiválóság Program keretében megvalósult kutatás rövid összefoglalása, amelynek célja, hogy empirikus adatokat vizsgálva betekintést nyújtson a leendő tanárok nyelvi változatossággal kapcsolatos nézeteibe, feltárja a háttérben húzódó ideológiákat, és felmérje, hogy melyek azok a csoportok, amelyeket az adatközlők (különböző jegyek mentén) másként tematizálnak. Az eredmények szerint a tanárképzésben részt vevő hallgatók diskurzusaiban megjelenik a másság kategorizációja. A másságot egyrészt a látható fizikai különbözőségek mentén határozzák meg, ugyanakkor a kisebb csoportok, az egyéni különbségek is előtérbe kerülnek.
Hazánkban használt szókincsmérő eljárások II.
Authors: Juhász Valéria , Radics Márta
Published: September 2023

A szövegértési, tanulási képesség meghatározó összetevője a szókincs, ezért a gyerekek szókincsének a feltérképezése hozzásegít a tudatosan tervezhető tanítási, fejlesztői munkához. A tanulmány első része bemutatta a szókincs fejlődésére vonatkozó kutatásokat, majd különböző szókincsvizsgálati módszereket ismertetett. A tanulmány második felében olyan vizsgálatok, eljárások bemutatása következik, amelyek egy-egy komplex nyelvi vizsgálóeljárás részei óvodás korban, iskolába lépéskor, avagy kisiskolás korban. A tanulmány második felében szóolvasó készséget vizsgáló teszteket ismerhet meg az olvasó. A bemutatott eljárások egy része kötelező szűrővizsgálatok részét is képezi. Az egyén szókincsének feltérképezésére irányuló módszerek megismerése azért fontos, mert általuk képet kaphatunk a gyermekek esetleges elmaradásairól, és célzott fejlesztéssel segíthetjük a szövegértési és a tanulási képességének a fejlődését.
Új nézőpontok az anyanyelvi nevelés „hallgatói műhelyében”. Beszámoló a 36. OTDK Tanulás- és Tanításmódszertani – Tudástechnológiai Szekciójában a Magyar nyelv és irodalom pedagógiája tagozat munkájáról
Authors: Kovács Tibor Attila
Published: September 2023

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Beszámoló a XI. országos anyanyelvtanítási versenyről
Authors: Gonda Zsuzsa , Takács Judit
Published: September 2023

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A nyelvjárási tudat fejlesztésének útján II. Újabb feladatok a nyelvjárási témakör tanításához
Authors: Bereczk Zsófia Mirtill , Parapatics Andrea
Published: September 2023

A két részből álló dolgozat második írása elsősorban a nyelvjárástani ismeretek feldolgozásához kíván segítséget nyújtani különféle munkaformákra és feladattípusokra épülő, saját fejlesztésű tanítási ötletek közlésével. A köznevelés és akár az egyetemi képzés különböző szintjein egyaránt alkalmazható feladatok célja, hogy élményszerűen, a tanulók és a hallgatók nyelvérzékére, és ha van, nyelvi hátterére építve mutassák be a nyelv területi változatosságának természetes voltát. A témakör fontos eleme a pozitív attitűd kialakítása, a tévhitek minél meggyőzőbb eloszlatása, adott esetben a sztereotípiák cáfolata, ezért a bemutatott feladatok erre is törekszenek. A pandémiás időszak tapasztalatai alapján a tanítási ötletek többsége az online oktatási közegben is megvalósítható. A feladatok alapjául a nyugat-dunántúli régió közel 200 középiskolás tanulója körében végzett empirikus kutatás eredményei is szolgáltak. Ezeket a dolgozat első része, a folyóirat jelen számának Tanulmányok rovata mutatja be részletesen.
A szövegalkotási kompetencia megjelenése a Nemzeti alaptantervekben
Authors: Juhász Milán
Published: September 2023

Magyarországon a köznevelési rendszer legfelső szintű közös tanulmányi terve a Nemzeti alaptanterv, amely azokat a szükséges és nélkülözhetetlen tartalmakat foglalja magába, amelyeket a tanulóknak általános és középiskolai képzésük során el kell sajátítaniuk. Jelen tanulmány a dokumentumelemzés módszerével vizsgálja, hogy a Magyarországon eddig megjelent öt Nemzeti alaptanterv alapelveiben és céljaiban, műveltségterületeinek leírásaiban, kiemelt fejlesztési feladataiban hogyan és milyen mértékben jelenik meg a szövegalkotási kompetencia. A tanulmány bemutatja, hogy a különböző képzési szinteken mely szövegtípusok ismeretei elvárt követelmények, a szövegalkotási kompetencia fejlesztésére mely tevékenységeket írja elő az öt dokumentum, valamint rávilágít arra is, hogy ezek az elvárások és tevékenységek hogyan változtak a magyar nyelv és irodalom műveltségterületen belül a Nemzeti alaptanterv változása során.
Az anyanyelvi nevelés játékos fejlesztői, az Ékesszólás Kiskönyvtára sorozat feladatgyűjteményei
Authors: Tomori Tímea
Published: September 2023

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Crust-Mantle Interaction Controls the Formation of High-Mg Adakitic Rocks: Evidence from Early Cretaceous Intrusive Complexes in Luxi Terrane, North China Craton
Authors: Liu Songyan , Shi Kangxing , Zhang Da , Wang Changming , Du Bin , Chen Qi , Gao Lei
Published: September 2023

High-Mg adakite rocks preserve crucial information about the crust-mantle interactions during the magma evolution. The Luxi Terrane, southeastern North China Craton, stores a set of Early Cretaceous high-Mg adakite rocks; nevertheless, their petrogenesis remains controversial. In this study, we present new whole-rock geochemistry, zircon U-Pb-Hf isotopes in the Tiezhai, Jinxingtou, and Sanshanyu complexes which are composed of gabbroic diorite, diorites, syenites, and monzonites. Field observations and zircon U-Pb dating indicate that all of the rock units crystallized contemporaneously at ca. 125–120 Ma. They are characterized by high Al2O3 and Sr contents, and low MgO, Y, Yb, and heavy rare earth elements contents, coupled with high Sr/Y values (42–163), showing adakitic affinities. The magma mixing process is supported by the following ample evidence: (1) the disequilibrium mineral textures and mafic enclaves; (2) high Mg# values (37–69, Mean = 58); and (3) widely zircons εHf(t) values (−25.6 to +7.8). The signature geochemical characteristics support that the adakites were generated by magma mixing of ancient crust-derived melts and relatively mafic melts from metasomatized mantle source. In combined with regional geology, the Early Cretaceous high-Mg adakites in Luxi Terrane represent the magmatic response of intensive crust-mantle interaction caused by the underplating of voluminous mantle-derived magma in an extension intracontinental setting.
The Late Paleocene–Eocene Extension and Differential Denudation in the Eastern Daqingshan Mountains Around the Northeastern Margin of the Ordos Block, Western North China Craton, Constrained by Apatite (U-Th)/He Thermochronology
Authors: Feng Lixia , Han Baofu , Wu Lin , Han Zhongpeng , Zhang Jiawei , Liu Mei
Published: September 2023

The initial timing of extension during the Cenozoic around the northeastern margin of the Ordos Block, western North China Craton (NCC), is still poorly constrained. Apatite (U-Th)/He low-temperature thermochronology was thus applied on eight pre-Cenozoic granitic and gneissic samples transecting the eastern Daqingshan Mountains, northeastern margin of the Ordos Block, to investigate the denudation and cooling event related to the onset of extension therein. Four mean corrected AHe ages in the southern part are overlapped within the standard deviations of 50.0 ± 0.4 to 45.0 ± 8.0 Ma. However, three mean corrected AHe ages in the northern part are prominently older of 99.2 ± 11.0 to 86.6 ± 17.1 Ma, with the rest one of 56.1 ± 8.6 Ma. Altogether, they show a younger-older-younger-older pattern along the transect correlated with the normal faults. AHe thermal history modeling results further demonstrate extensive cooling during the Late Cretaceous but differential cooling during the Late Paleocene–Eocene. The Late Cretaceous extensive cooling in the eastern Daqingshan Mountains, as well as the contemporaneous deposition hiatus in both the eastern Daqingshan Mountains and the Hohhot Depression, together indicates overall denudation in the northeastern margin of the Ordos Block at that time. The Late Paleocene–Eocene differential cooling is probably induced by the tilting of the eastern Daqingshan Mountains as a result of the extension suggested by the distribution of AHe ages. It corresponds to the syn-tectonic subsidence in the Hohhot Depression, indicating a basin-mountain coupling. Regional comparative analysis manifests similar extension around the Ordos Block and more widely across the NCC during the Late Paleocene–Eocene. Temporally, kinematically, and dynamically coupled with this regional extension event, the subduction of the Izanagi-Pacific plate probably plays a major role. However, the contribution of the India-Asia collision could not be ignored.
Mesozoic-Cenozoic Topographic Evolution of the South Tianshan (NW China): Insights from Detrital Apatite Geo-Thermochronological and Geochemical Analyses
Authors: Xiang Dunfeng , Zhang Zhiyong , Chew David , Jolivet Marc , Malusà Marco G. , Guo Chao , Wang Nan , Xiao Wenjiao
Published: September 2023

The present-day topography of Tianshan is the product of repeated phases of Meso-Cenozoic intracontinental deformation and reactivation, whereas the long-term Mesozoic topographic evolution and the timing of the onset of Cenozoic deformation remain debated. New insights into the Meso-Cenozoic geodynamic evolution and related basin-range interactions in the Tianshan were obtained based on new detrital single-grain apatite U-Pb, fission-track, and trace-element provenance data from Mesozoic sedimentary sequences on the northern margin of the Tarim Basin. Detrital apatite U-Pb age data from Early-Middle Triassic clastic rocks show two prominent age populations at 500–390 Ma and 330–260 Ma, with a paucity of ages between 390 and 330 Ma, suggesting that sediment source is predominantly from the northern Tarim and South Tianshan. From the Late Triassic to Early Jurassic, the first appearance of populations in the 390–330 Ma and 260–220 age ranges indicates that the Central Tianshan-Yili Block and Western Kunlun Orogen were source regions for the northern margin of Tarim Basin. In the Cretaceous strata, south-directed paleocurrents combined with the decrease in the 390–330 Ma age population from the Central Tianshan-Yili Block imply that South Tianshan was uplifted and again became the main source region to the Baicheng-Kuqa depression during the Cretaceous. Our new apatite fission-track data from the southern Chinese Tianshan suggest that rapid cooling commenced at c. 30 Ma along the southern margin, and the Early Mesozoic strata exposed on the southern flank of the Tianshan underwent c. 4–5 km of late Cenozoic exhumation during this period. This age is approximately synchronous with the onset of exhumation/deformation not only in the whole Tianshan but also in the interior of the Tibetan Plateau and its margins. It suggests that far-field, N-directed shortening resulting from the India-Asia collision was transmitted to the Tianshan at that time.
Volcanic Age and Geochemistry of the Permian Linxi Formation in Northeast China: Implications for the Tectonic Evolution of the Paleo-Asian Ocean
Authors: Zhang Haihua , Zhang Hua , Shen Shuzhong , Zhao Zifu , Qiu Liang , Chen Shuwang , Zhang Jian , Gong Fanhao , Li Yongfei , Zheng Yuejuan , Sun Shouliang , Zhang Yujin
Published: September 2023

The tectonic evolution of the Paleo-Asian Ocean (PAO) has been well studied, including its gradual narrowing and closure by subduction. However, aspects of the tectonic evolution of the oceanic domain remain unclear, including the exact timing and nature of the closure. The Central Asian Orogenic Belt (CAOB) was formed by the closure of the PAO and, therefore, contains information about the tectonic evolution of the oceanic domain. Here, we report a study of the petrology, geochronology, and geochemistry of the Taohaiyingzi section of the Permian Linxi Formation in Alukhorqin Banner (Northeast China) in the central part of the CAOB. A newly discovered andesitic tuff from the lower part of the Linxi Formation yields a weighted mean 206Pb/238U age of 262.2 ± 1.1 Ma (n = 87), indicating that the lower part of the Linxi Formation of the Taohaiyingzi section was deposited during the late Guadalupian. Provenance weathering indicators show that the sedimentary rocks of the Linxi Formation are of low maturity. Element geochemical characteristics indicate that the Linxi Formation clastic rocks were derived from eroded magmatic rocks that formed in a continental arc setting and were deposited close to the arc in a continental arc basin environment. The active margin setting was generated by the subduction of the paleo-Asian oceanic plate beneath the Xilinhot–Songliao block. The inferred palaeosalinity of the sedimentary environment changed gradually from brackish to fresh water, suggesting the end of oceanic plate subduction during the late Guadalupian, and the closure of the PAO during or after the Lopingian.
Polygenic risk for triglyceride levels in the presence of a high impact rare variant
Authors: Ying Shengjie , Heung Tracy , Thiruvahindrapuram Bhooma , Engchuan Worrawat , Yin Yue , Blagojevic Christina , Zhang Zhaolei , Hegele Robert A. , Yuen Ryan K. C. , Bassett Anne S.
Published: September 2023

Background
Elevated triglyceride (TG) levels are a heritable and modifiable risk factor for cardiovascular disease and have well-established associations with common genetic variation captured in a polygenic risk score (PRS). In young adulthood, the 22q11.2 microdeletion conveys a 2-fold increased risk for mild-moderate hypertriglyceridemia. This study aimed to assess the role of the TG-PRS in individuals with this elevated baseline risk for mild-moderate hypertriglyceridemia.
Methods
We studied a deeply phenotyped cohort of adults (n=157, median age 34 years) with a 22q11.2 microdeletion and available genome sequencing, lipid level, and other clinical data. The association between a previously developed TG-PRS and TG levels was assessed using a multivariable regression model adjusting for effects of sex, BMI, and other covariates. We also constructed receiver operating characteristic (ROC) curves using logistic regression models to assess the ability of TG-PRS and significant clinical variables to predict mild-moderate hypertriglyceridemia status.
Results
The TG-PRS was a significant predictor of TG-levels (p=1.52E-04), along with male sex and BMI, in a multivariable model (pmodel=7.26E-05). The effect of TG-PRS appeared to be slightly stronger in individuals with obesity (BMI ≥ 30) (beta=0.4617) than without (beta=0.1778), in a model unadjusted for other covariates (p-interaction=0.045). Among ROC curves constructed, the inclusion of TG-PRS, sex, and BMI as predictor variables produced the greatest area under the curve (0.749) for classifying those with mild-moderate hypertriglyceridemia, achieving an optimal sensitivity and specificity of 0.746 and 0.707, respectively.
Conclusions
These results demonstrate that in addition to significant effects of sex and BMI, genome-wide common variation captured in a PRS also contributes to the variable expression of the 22q11.2 microdeletion with respect to elevated TG levels.
Green synthesis of silver nanoparticles by S.nervosum leaf extract exhibits high antibacterial activity
Authors: Cong Hong Hanh , Pham Sy Hieu , Nguyen Hong Nhung , Tran Que Chi , Tran Thi Huong , Pham Duy Khanh , Pham Thi Gam , Nguyen Van Phuong , Thi Thanh Nga Phan , Hoang Hien Y , Dao My Uyen , Hoang Anh Son
Published: September 2023

In this study, green synthesis and physicochemical characterization of silver nanoparticles (AgNPs) using S.nervosum leaf extract. The characteristic surface plasmon resonance peak observed in the visible region at 435 nm is consistent with previous reports of silver nanoparticle formation. The synthesized AgNPs were also characterized by SEM, TEM, XRD, and FTIR, which reveal their nearly spherical shape, mainly in the 10–30 nm diameter. The antimicrobial activity of AgNPs was studied using the agar-well diffusion method on four clinically significant pathogenic microorganisms (P.aeruginosa ATCC 27853; E.coli ATCC 35218, S.aureus ATCC 12493; S.aureus Mastitis isolate). The results showed that the green synthesized AgNPs exhibited antimicrobial activity at most studied concentrations, including the antibacterial effect against S.aureus (Mastitis isolate) strain, which was found to be resistant to Tetracycline 100 µg/L. The antifungal activity of these nanoparticles was also studied on Colletotrichum gloeopsoriodes by colony formation assay. The green synthesis of silver nanoparticles (AgNPs) was successfully conducted for the first time utilizing the aqueous extract of S.nervosum. The results of this study indicate that silver nanoparticles have potential applications as antibacterial and antifungal agents.
Variability in interseismic strain accumulation rate and style along the Altyn Tagh Fault
Authors: Shen Lin , Hooper Andrew , Elliott John , Wright Tim
Published: September 2023

Major strike-slip faults that develop between strong and weaker regions are thought to focus along narrow shear zones at the rheological boundary. Here we present the first InSAR-derived velocity field spanning almost the entire length of one such fault, the 1600 km-long Altyn Tagh Fault (ATF), and analyse the strain distribution. We find that localisation of strain is actually variable, with strain concentrated at the fault for some sections and distributed over broad (>100 km) shear zones for others. This contrasts to the North Anatolian and central San Andreas faults, where strain rate varies little along the entire length. Slip rate along the ATF is also variable, decreasing along the fault from 11.6 ± 1.0 mm/yr in the west to 7.5 ± 1.2 mm/yr in the central portion, before increasing again to 11.1 ± 1.1 mm/yr over the eastern portion. These results imply that the role of the ATF as a main controlling fault up against a rigid Tarim Basin is smaller than previously thought, with sub-parallel faults playing an important role in the overall deformation. This demonstrates the importance of accurately characterising strain rates over a broad region when assessing seismic hazard.