bluuebunny/crossref_metadata_2025 huggingface dataset:
Stellar populations and star formation histories of the most extreme [O iii] emitters at z = 1.3 − 3.7
Authors: Tang Mengtao , Stark Daniel P , Ellis Richard S
Published: May 2022

As the James Webb Space Telescope approaches scientific operation, there is much interest in exploring the redshift range beyond that accessible with Hubble Space Telescope imaging. Currently, the only means to gauge the presence of such early galaxies is to age-date the stellar population of systems in the reionisation era. As a significant fraction of z ≃ 7−8 galaxies are inferred from Spitzer photometry to have extremely intense [O iii] emission lines, it is commonly believed these are genuinely young systems that formed at redshifts z < 10, consistent with a claimed rapid rise in the star formation density at that time. Here, we study a spectroscopically confirmed sample of extreme [O iii] emitters at z = 1.3−3.7, using both dynamical masses estimated from [O iii] line widths and rest-frame UV to near-infrared photometry to illustrate the dangers of assuming such systems are genuinely young. For the most extreme of our intermediate redshift line emitters, we find dynamical masses 10−100 times that associated with a young stellar population mass, which are difficult to explain solely by the presence of additional dark matter or gaseous reservoirs. Adopting non-parametric star formation histories, we show how the near-infrared photometry of a subset of our sample reveals an underlying old (>100 Myr) population whose stellar mass is ≃ 40 times that associated with the starburst responsible for the extreme line emission. Without adequate rest-frame near-infrared photometry, we argue it may be premature to conclude that extreme line emitters in the reionisation era are low-mass systems that formed at redshifts below z ≃ 10.
An exploration of X-ray Supernova remnants in the Milky Way and nearby galaxies
Authors: Albert Chris , Dwarkadas Vikram V
Published: May 2022

We probe the environmental properties of X-ray supernova remnants (SNRs) at various points along their evolutionary journey, especially the S-T phase, and their conformance with theoretically derived models of SNR evolution. The remnant size is used as a proxy for the age of the remnant. Our data set includes 34 Milky Way, 59 Large Magellanic Cloud (LMC), and 5 Small Magellanic Cloud (SMC) SNRs. We select remnants that have been definitively typed as either core-collapse (CC) or Type Ia supernovae, with well-defined size estimates, and a thermal X-ray flux measured over the entire remnant. A catalog of SNR size and X-ray luminosity is presented and plotted, with ambient density and age estimates from the literature. Model remnants with a given density, in the Sedov-Taylor (S-T) phase, are overplotted on the diameter-versus-luminosity plot, allowing the evolutionary state and physical properties of SNRs to be compared to each other, and to theoretical models. We find that small, young remnants are predominantly Type Ia remnants or high luminosity CCs, suggesting that many CC SNRs are not detected until after they have emerged from the progenitor’s wind-blown bubble. An examination of the distribution of SNR diameters in the Milky Way and LMC reveals that LMC SNRs must be evolving in an ambient medium which is 30 per cent as dense as that in the Milky Way. This is consistent with ambient density estimates for the Galaxy and LMC.
The spatial distribution of satellites in galaxy clusters
Authors: Gu Qing , Guo Qi , Zhang Tianchi , Cautun Marius , Lacey Cedric , Frenk Carlos S , Shao Shi
Published: May 2022

The planar distributions of satellite galaxies around the Milky Way and Andromeda have been extensively studied as potential challenges to the standard cosmological model. Using the Sloan Digital Sky Survey and the Millennium simulation, we extend such studies to the satellite galaxies of massive galaxy clusters. We find that both observations and simulations of galaxy clusters show an excess of anisotropic satellite distributions. On average, satellites in clusters have a higher degree of anisotropy than their counterparts in Milky-Way-mass hosts once we account for the difference in their radial distributions. The normal vector of the plane of satellites is strongly aligned with the host halo’s minor axis, while the alignment with the large-scale structure is weak. At fixed cluster mass, the degree of anisotropy is higher at higher redshift. This reflects the highly anisotropic nature of satellites accretion points, a feature that is partly erased by the subsequent orbital evolution of the satellites. We also find that satellite galaxies are mostly accreted singly so group accretion is not the explanation for the high flattening of the planes of satellites.
Mutation Load in Sunflower Inversions Is Negatively Correlated with Inversion Heterozygosity
Authors: Huang Kaichi , Ostevik Kate L. , Elphinstone Cassandra , Todesco Marco , Bercovich Natalia , Owens Gregory L. , Rieseberg Loren H.
Published: May 2022

Recombination is critical both for accelerating adaptation and purging deleterious mutations. Chromosomal inversions can act as recombination modifiers that suppress local recombination in heterozygotes and thus, under some conditions, are predicted to accumulate such mutations. In this study, we investigated patterns of recombination, transposable element abundance, and coding sequence evolution across the genomes of 1,445 individuals from three sunflower species, as well as within nine inversions segregating within species. We also analyzed the effects of inversion genotypes on 87 phenotypic traits to test for overdominance. We found significant negative correlations of long terminal repeat retrotransposon abundance and deleterious mutations with recombination rates across the genome in all three species. However, we failed to detect an increase in these features in the inversions, except for a modest increase in the proportion of stop codon mutations in several very large or rare inversions. Consistent with this finding, there was little evidence of overdominance of inversions in phenotypes that may relate to fitness. On the other hand, significantly greater load was observed for inversions in populations polymorphic for a given inversion compared to populations monomorphic for one of the arrangements, suggesting that the local state of inversion polymorphism affects deleterious load. These seemingly contradictory results can be explained by the low frequency of inversion heterozygotes in wild sunflower populations, apparently due to divergent selection and associated geographic structure. Inversions contributing to local adaptation represent ideal recombination modifiers, acting to facilitate adaptive divergence with gene flow, while largely escaping the accumulation of deleterious mutations.
HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript
Authors: Vo Tam , Brownmiller Tayvia , Hall Katherine , Jones Tamara L , Choudhari Sulbha , Grammatikakis Ioannis , Ludwig Katelyn R , Caplen Natasha J
Published: May 2022

In the presence of physiological monovalent cations, thousands of RNA G-rich sequences can form parallel G-quadruplexes (G4s) unless RNA-binding proteins inhibit, destabilize, or resolve the formation of such secondary RNA structures. Here, we have used a disease-relevant model system to investigate the biophysical properties of the RNA-binding protein HNRNPH1’s interaction with G-rich sequences. We demonstrate the importance of two EWSR1-exon 8 G-rich regions in mediating the exclusion of this exon from the oncogenic EWS-FLI1 transcripts expressed in a subset of Ewing sarcomas, using complementary analysis of tumor data, long-read sequencing, and minigene studies. We determined that HNRNPH1 binds the EWSR1-exon 8 G-rich sequences with low nM affinities irrespective of whether in a non-G4 or G4 state but exhibits different kinetics depending on RNA structure. Specifically, HNRNPH1 associates and dissociates from G4-folded RNA faster than the identical sequences in a non-G4 state. Importantly, we demonstrate using gel shift and spectroscopic assays that HNRNPH1, particularly the qRRM1-qRRM2 domains, destabilizes the G4s formed by the EWSR1-exon 8 G-rich sequences in a non-catalytic fashion. Our results indicate that HNRNPH1’s binding of G-rich sequences favors the accumulation of RNA in a non-G4 state and that this contributes to its regulation of RNA processing.
Manipulating high-temperature superconductivity by oxygen doping in Bi2Sr2CaCu2O8+δ thin flakes
Authors: Lei Bin , Ma Donghui , Liu Shihao , Sun Zeliang , Shi Mengzhu , Zhuo Weizhuang , Yu Fanghang , Gu Genda , Wang Zhenyu , Chen Xianhui
Published: May 2022

Harnessing the fascinating properties of correlated oxides requires precise control of their carrier density. Compared to other methods, oxygen doping provides an effective and more direct way to tune the electronic properties of correlated oxides. Although several approaches, such as thermal annealing and oxygen migration, have been introduced to change the oxygen content, a continuous and reversible solution that can be integrated with modern electronic technology is much in demand. Here, we report a novel ionic field-effect transistor using solid Gd-doped CeO2 as the gate dielectric, which shows a remarkable carrier-density-tuning ability via electric-field-controlled oxygen concentration at room temperature. In Bi2Sr2CaCu2O8+δ (Bi-2212) thin flakes, we achieve a reversible superconductor–insulator transition by driving oxygen ions in and out of the samples with electric fields, and map out the phase diagram all the way from the insulating regime to the over-doped superconducting regime by continuously changing the oxygen doping level. Scaling analysis indicates that the reversible superconductor–insulator transition for the Bi-2212 thin flakes follows the theoretical description of a two-dimensional quantum phase transition. Our work provides a route for realizing electric-field control of phase transition in correlated oxides. Moreover, the configuration of this type of transistor makes heterostructure/interface engineering possible, thus having the potential to serve as the next-generation all-solid-state field-effect transistor.
Detection of SARS-CoV-2 by Canine Olfaction: A Pilot Study
Authors: Maurer Maureen , Seto Todd , Guest Claire , Somal Amendeep , Julian Catherine
Published: May 2022

Background

As the number of coronavirus disease 2019 (COVID-19) cases continue to surge worldwide and new variants emerge, additional accurate, rapid, and noninvasive screening methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed. The number of COVID-19 cases reported globally is >455 million, and deaths have surpassed 6 million. Current diagnostic methods are expensive, invasive, and produce delayed results. While COVID-19 vaccinations are proven to help slow the spread of infection and prevent serious illness, they are not equitably available worldwide. Almost 40% of the world’s population remains unvaccinated. Evidence suggests that SARS-CoV-2 virus–associated volatile organic compounds found in the breath, urine, and sweat of infected individuals can be detected by canine olfaction. Medical detection dogs may be a feasible, accurate, and affordable SARS-CoV-2 screening method.

Methods

In this double-blinded, case–control, validation study, we obtained sweat samples from inpatients and outpatients tested for SARS-CoV-2 by a polymerase chain reaction test. Medical detection dogs were trained to distinguish SARS-CoV-2-positive samples from SARS-CoV-2-negative samples using reward-based reinforcement.

Results

Samples were obtained from 584 individuals (6–97 years of age; 24% positive SARS-CoV-2 samples and 76% negative SARS-CoV-2 samples). In the testing phase, all dogs performed with high accuracy in detecting SARS-CoV-2. The overall diagnostic sensitivity was 98%, and specificity was 92%. In a follow-up phase, 1 dog screened 153 patients for SARS-CoV-2 in a hospital setting with 96% diagnostic sensitivity and 100% specificity.

Conclusions

Canine olfaction is an accurate and feasible method for diagnosis of SARS-CoV-2, including asymptomatic and presymptomatic infected individuals.
H3K27 methylation regulates the fate of two cell lineages in male gametophytes
Authors: Huang Xiaorong , Sun Meng-Xiang
Published: May 2022

During angiosperm male gametogenesis, microspores divide to produce a vegetative cell (VC) and a male germline (MG), each with distinct cell fates. The mechanism underlying determination of the MG cell/VC fate remains an important area of research, with many unanswered questions. Here, we report that H3K27me3 is essential for VC fate commitment in male Arabidopsis thaliana gametophytes; H3K27me3 erasure contributes to MG cell fate initiation. VC-targeted H3K27me3 erasure disturbed VC development and shifted the VC fate toward a gamete destination, which suggests that MG cells require H3K27me3 erasure to trigger gamete cell fate. Multi-omics and cytological analyses confirmed the occurrence of extensive cell identity transition due to H3K27me3 erasure. Therefore, we experimentally confirmed that MG cell/VC fate is epigenetically regulated. H3K27 methylation plays a critical role in guiding MG cell/VC fate determination for pollen fertility in Arabidopsis. Our work also provides evidence for two previous hypotheses: the germline cell fate is specified by the differential distribution of unknown determinants and VC maintains the default microspore program (i.e. the H3K27me3 setting) while MG requires reprogramming.
The transcription factor bZIP68 negatively regulates cold tolerance in maize
Authors: Li Zhuoyang , Fu Diyi , Wang Xi , Zeng Rong , Zhang Xuan , Tian Jinge , Zhang Shuaisong , Yang Xiaohong , Tian Feng , Lai Jinsheng , Shi Yiting , Yang Shuhua
Published: May 2022

Maize (Zea mays) originated in tropical areas and is thus susceptible to low temperatures, which pose a major threat to maize production. Our understanding of the molecular basis of cold tolerance in maize is limited. Here, we identified bZIP68, a basic leucine zipper (bZIP) transcription factor, as a negative regulator of cold tolerance in maize. Transcriptome analysis revealed that bZIP68 represses the cold-induced expression of DREB1 transcription factor genes. The stability and transcriptional activity of bZIP68 are controlled by its phosphorylation at the conserved Ser250 residue under cold stress. Furthermore, we demonstrated that the bZIP68 locus was a target of selection during early domestication. A 358-bp insertion/deletion (Indel-972) polymorphism in the bZIP68 promoter has a significant effect on the differential expression of bZIP68 between maize and its wild ancestor teosinte. This study thus uncovers an evolutionary cis-regulatory variant that could be used to improve cold tolerance in maize.
Three OsMYB36 members redundantly regulate Casparian strip formation at the root endodermis
Authors: Wang Zhigang , Zhang Baolei , Chen Zhiwei , Wu Mingjuan , Chao Dong , Wei Qiuxing , Xin Yafeng , Li Longying , Ming Zhenhua , Xia Jixing
Published: May 2022

Plants have evolved a lignin-based Casparian strip (CS) in roots that restricts passive diffusion of mineral elements from the soil to the stele. However, the molecular mechanisms underlying CS formation in rice (Oryza sativa), which contains a CS at both the exodermis and endodermis, are poorly understood. Here, we demonstrate that CS formation at the rice endodermis is redundantly regulated by three MYELOBLASTOSIS (MYB) transcription factors, OsMYB36a, OsMYB36b, and OsMYB36c, that are highly expressed in root tips. Knockout of all three genes resulted in a complete absence of CS at the endodermis and retarded plant growth in hydroponic conditions and in soil. Compared with the wild-type, the triple mutants showed higher calcium (Ca) levels and lower Mn, Fe, Zn, Cu, and Cd levels in shoots. High Ca supply further inhibited mutant growth and increased Ca levels in shoots. Transcriptome analysis identified 1,093 downstream genes regulated by OsMYB36a/b/c, including the key CS formation gene OsCASP1 and other genes that function in CS formation at the endodermis. Three OsMYB36s regulate OsCASP1 and OsESB1 expression by directly binding to MYB-binding motifs in their promoters. Our findings thus provide important insights into the mechanism of CS formation at the endodermis and the selective uptake of mineral elements in roots.
Thrombocytopenia in primary antiphospholipid syndrome: association with prognosis and clinical implications
Authors: Shi Yu , Zhao Jiuliang , Jiang Hui , Huang Can , Qi Wanting , Song Yijun , Wang Qian , Li Mengtao , Tian Xinping , Zhao Yongqiang , Zeng Xiaofeng
Published: May 2022

Objectives

Thrombocytopenia, a frequent clinical manifestation in patients with APS, could be an independent predictor of recurrent thrombotic, obstetric and severe extracriteria events.

Methods

This single-centre prospective study enrolled 218 consecutive patients diagnosed with primary APS between 2010 and 2021. Thrombocytopenia was defined as a platelet count less than 100 × 109/L.

Results

Our cohort included 74 (33.94%) patients with thrombocytopenia and 144 patients with a continuous normal platelet count. Comparison of baseline characteristics indicated that patients with thrombocytopenia had more visceral venous thromboses [10 (13.51%) vs 5(3.47%); P = 0.009] and extracriteria manifestations [mainly haemolytic anaemia; 20 (27.03%) vs 17 (11.81%); P = 0.007]. Hypocomplementemia was more likely among patients with thrombocytopenia [19 (25.68%) vs 16 (11.11%); P = 0.01]. The presence of aCL-IgG/IgM, anti-β2-glycoprotein I and lupus anticoagulant were more frequently detected in patients with thrombocytopenia. In survival analysis, thrombotic, obstetric and severe extracriteria survival rates were significantly worse in patients with thrombocytopenia. In multivariate Cox regression, thrombocytopenia was an independent risk factor for all endpoint events, including thrombotic events [hazard ratio (HR) 2.93 (95% CI 1.31, 6.56), P = 0.009], pregnancy morbidity [HR 8.00 (95% CI 2.43, 26.37), P = 0.0006] and severe extracriteria events [HR 15.27 (95% CI 1.85, 125.98), P = 0.01].

Conclusion

Thrombocytopenia could identify primary APS patients at high risk of developing thrombotic events, pregnancy morbidity and severe extracriteria events.
Multimodality Imaging for Cardiotoxicity: State of the Art and Future Perspectives
Authors: Artico Jessica , Abiodun Aderonke , Shiwani Hunain , Kurdi Hibba , Chen Daniel , Tyebally Sara , Moon James C. , Westwood Mark , Manisty Charlotte H.
Published: May 2022

Modern cancer therapies have significantly improved survival leading to a growing population of cancer survivors. Similarly, both conventional and newer treatments are associated with a spectrum of cardiovascular disorders with potential long-term sequelae. Prompt detection and treatment of these complications is, therefore, pivotal to enable healthy survivorship and reduce cardiovascular morbidity. Advanced multimodality imaging is a valuable tool for stratifying patient risk, identifying cardiovascular toxicity during and after therapy, and predicting recovery. This review summarizes the potential cardiotoxic complications of anticancer therapies and the multimodality approaches available in each case with special focus on newer techniques and the added value of biomarkers ultimately leading to earlier diagnosis and better prognostication.
miR-320a Targeting RGS5 Aggravates Atherosclerosis by Promoting Migration and Proliferation of ox-LDL–Stimulated Vascular Smooth Muscle Cells
Authors: Zhang Chi , Wang Xun
Published: May 2022

MicroRNAs have been implicated in atherosclerosis (AS) progression. Here, we focused on how miR-320a affect AS progression via vascular smooth muscle cells (VSMCs). Oxidized low-density lipoproteins (ox-LDL)–stimulated VSMCs were used as an AS cell model, and qRT-PCR was performed to measure miR-320a and regulators of G protein signaling (RGS5) levels. CCK-8 and wound healing assays were used to detect the viability and migration of VSMCs. Western blotting was used to measure the protein expression levels of PCNA, Bax, and Bcl-2. The interaction of miR-320a and RGS5 was determined by dual luciferase and RNA pull-down assays. MiR-320a was highly expressed, whereas RGS5 showed low levels of expression in the arterial plaque tissues. Silencing of miR-320a blocked cell viability and migration, inhibited expression of the proliferation-specific protein PCNA in ox-LDL–treated VSMCs, promoted Bax protein expression, and inhibited Bcl-2 protein expression. Furthermore, miR-320a was found to exert these effects by inhibiting RGS5 expression. Collectively, miR-320a promoted cell viability, migration, and proliferation while reducing apoptosis of ox-LDL–stimulated VSMCs by inhibiting RGS5.
Intra-Abdominal Pressure Measurement Devices
Authors: Crumley Carolyn
Published: May 2022

PURPOSE:

The purpose of this Technologic Analysis is to review devices designed to measure intra-abdominal pressure (IAP); these devices are used to detect intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS).

APPROACH:

Published literature focusing on devices designed to measure IAP was reviewed, comparing the options available and outlining recommendations for appropriate use. Safety information regarding IAP measurement devices was derived from the Manufacturer and User Facility Device Experience (MAUDE) database.

CONCLUSIONS:

Intra-abdominal hypertension is prevalent among critically ill patients of all ages and is linked to adverse consequences, such as abdominal compartment syndrome. The condition is often unrecognized due to the lack of overt clinical symptoms, supporting the need for devices to accurately measure IAP. Commercially available devices measure IAP indirectly, typically via the bladder or stomach. Additional research is needed to demonstrate the benefits of routine screening, further define risk factors for IAH/ACS development, and evaluate the impact of measures to reduce IAP in an effort to improve patient outcomes.
Moisture-Associated Skin Damage
Authors: McNichol Laurie , Bliss Donna Z. , Gray Mikel
Published: May 2022

Moisture-associated skin damage (MASD) occurs when skin is repeatedly exposed to various sources of bodily secretions or effluents, often leading to irritant contact dermatitis, characterized by inflammation with or without denudation of affected skin. In 2020, the Wound, Ostomy and Continence Nurses Society commissioned an initiative that led to the addition of multiple International Classification of Diseases, Tenth Revision, Clinical Modification codes (ICD-10-CM) for irritant contact dermatitis caused by various forms of MASD for use in the United States. In a recent issue of the Journal of Wound, Ostomy and Continence Nursing, a clinical practice alert identifying the various new codes was published that summarized each of the new codes and provided highlights of the descriptions for each of these codes. This is the second in a series of 2 follow-up articles providing a more detailed description of the MASD conditions to which the newest irritant contact dermatitis ICD-10-CM codes apply. Specifically, this article reviews the clinical manifestations and assessment, pathophysiology, epidemiology, prevention, and management of irritant contact dermatitis associated with digestive secretions from a stoma or fistula, and fecal or urinary effluent from an abdominal stoma or enterocutaneous fistula.
Use of a Convex Pouching System in the Postoperative Period
Authors: Colwell Janice C. , Stoia Davis Janet , Emodi Krisztina , Fellows Jane , Mahoney Mary , McDade Bethany , Porten Sima , Raskin Elizabeth , Sims Terran , Norman Holly , Kelly Matthew T. , Gray Mikel
Published: May 2022

Convex pouching systems have been available for ostomy patients for decades; however, controversy remains over the use of convexity in the postoperative period. A group of 10 nurses and physicians with expertise caring for patients with an ostomy completed a scoping review identifying research-based evidence and gaps in our knowledge of the safety and effectiveness related to the use of a convex pouching system following ostomy surgery. Results of this scoping review demonstrated the need for a structured consensus to define best practices when selecting a pouching system that provides a secure and reliable seal around the stoma, avoids undermining and leakage of effluent from the pouching system, and contributes to optimal health-related quality of life for patients following ostomy surgery. The expert panel reached consensus on 8 statements for the use of convex products immediately after surgery and throughout the first 6 months after stoma creation, as well as describing goals in choosing the best pouching system for the patient with an ostomy.
Survey Results on Use of a Convex Pouching System in the Postoperative Period
Authors: Stoia-Davis Janet , Colwell Janice C. , Emodi Krisztina , Fellows Jane , Mahoney Mary , McDade Bethany , Porten Sima P. , Raskin Elizabeth R. , Norman Holly S. , Kelly Matthew T. , Sims Terran
Published: May 2022

PURPOSE:

The purpose of this study was to validate time frames for postoperative care following stoma surgery and to determine participants' current practice with convex pouching systems during the postoperative period.

DESIGN:

A Cross-sectional survey.

SUBJECTS AND SETTING:

The sample comprised 332 ostomy care specialists practicing in the United States. Most (n = 220; 66%) had more than 10 years' experience caring for patients with ostomies, 82% (n = 272) were certified WOC or ostomy care nurses (CWOCN and COCN), and 7% (n = 23) were board-certified colorectal surgeons.

METHODS:

A 23-item online questionnaire was created for purposes of the study. Items in the questionnaire queried professional background and experience caring for patients with an ostomy. A single item was used to identify postoperative care periods following ostomy surgery. Additional items queried current practice patterns related to use of convex pouching systems and the timing of their use. Data were collected from January 18 to February 8, 2021.

RESULTS:

Most respondents (n = 270; 90%) agreed with the following postoperative periods after ostomy surgery: immediate postoperative period (days 0-8); postoperative period (days 9-30); and transition phase (days 31-180). Most respondents (n = 274; 95%) indicated they would use a convex pouching system when clinically appropriate during the first 30 days following ostomy surgery and 79% (n = 228) indicated using a convex pouching system regardless of when the surgery was performed. Less than 1% (n = 2) indicated never using convexity within the first 30 days following stoma surgery, and only 3% (n = 8) indicated avoidance of convexity pouching systems in the immediate postoperative period.

CONCLUSIONS:

Findings indicate that use of convexity during the postoperative period is prevalent to provide a secure seal and predictable wear time.
Implementation of Pressure Injury Prevention Strategies in Acute Care
Authors: Edsberg Laura E. , Cox Jill , Koloms Kimberly , VanGilder-Freese Catherine A.
Published: May 2022

PURPOSE:

The purpose of this study was to evaluate the implementation of pressure injury (PI) prevention strategies in adult acute care settings in the United States using the data from the 2018/2019 International Pressure Ulcer Prevalence (IPUP) Survey.

DESIGN:

Observational, cohort study with cross-sectional data collection and retrospective data analysis.

SUBJECTS AND SETTING:

The sample comprised 296,014 patients hospitalized in 1801 acute care facilities in the United States that participated in the 2018 and/or 2019 IPUP Survey. Slightly less than half (49.4%, n = 146,231) were male, 50% (n = 148,997) were female, 0.6% (n = 17,760) were unknown. Their mean age was 64.29 (SD 17.2) years.

METHODS:

Data from the 2018/2019 IPUP database were analyzed to evaluate the implementation of prevention strategies including repositioning, support surface use, head-of-bed (HOB) elevation, heel elevation, moisture management, minimizing linen layers, and nutritional support. Practices were analyzed for differences between patients without pressure injuries, and patients with Stage 1 and 2 hospital-acquired pressure injury (HAPI), and those with severe HAPIs (Stage 3, Stage 4, unstageable, and deep tissue pressure injury). Acute care unit types included critical or intensive care units, medical-surgical inpatient care units, and step-down units.

RESULTS:

Compliance rates to PI prevention strategies varied among patients at risk for HAPIs (Braden Scale for Pressure Sore Risk score ≤18). Daily skin assessment was performed for 86% of patients with no HAPIs and 96.8% of patients with severe HAPIs. Pressure redistribution was used in 74.6% of all patients and in over 90% of patients with severe HAPIs; however, compliance to routine repositioning was reported at lower levels between 67% and 84%, respectively. Heel elevation was reported for over 60% of the patients with severe HAPIs while 31.9% did not receive heel elevation, though only 6% were reported as not needing elevation. The majority of patients had HOB greater than the 30° at the time of the data collection; compliance with minimizing linen layers (≤3) was reported in 76% or more. Moisture management strategies were reportedly used in more than 71% of all patients and 89% for patients with severe HAPIs. Nutrition support was used for 55% to 82% of the patients and only documented as contraindicated in fewer than 2% of all groups.

CONCLUSION:

Study findings revealed substantial compliance rates to PI prevention strategies. Nevertheless, there is potential for improvement in the implementation of some of the most basic prevention strategies including repositioning, heel elevation, nutritional support, and moisture management.
Interrogating the Precancerous Evolution of Pathway Dysfunction in Lung Squamous Cell Carcinoma Using XTABLE
Authors: Roberts Matthew , Ogden Julia , Hossain A S Md Mukarram , Kerr Alastair , Dive Caroline , Beane Jennifer E , Lopez-Garcia Carlos
Published: May 2022

Lung squamous cell carcinoma (LUSC) is a type of lung cancer with a dismal prognosis that lacks adequate therapies and actionable targets. This disease is characterized by a sequence of low and high-grade preinvasive stages with increasing probability of malignant progression. Increasing our knowledge about the biology of these premalignant lesions (PMLs) is necessary to design new methods of early detection and prevention, and to identify the molecular processes that are key for malignant progression. To facilitate this research, we have designed XTABLE, an open-source application that integrates the most extensive transcriptomic databases of PMLs published so far. With this tool, users can stratify samples using multiple parameters and interrogate PML biology in multiple manners, such as two and multiple group comparisons, interrogation of genes of interests and transcriptional signatures. Using XTABLE, we have carried out a comparative study of the potential role of chromosomal instability scores as biomarkers of PML progression and mapped the onset of the most relevant LUSC pathways to the sequence of LUSC developmental stages. XTABLE will critically facilitate new research for the identification of early detection biomarkers and acquire a better understanding of the LUSC precancerous stages.
SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity
Authors: Manali Maria , Bissett Laura A. , Amat Julien A. R. , Logan Nicola , Scott Sam , Hughes Ellen C. , Harvey William T. , Orton Richard , Thomson Emma C. , Gunson Rory N. , Viana Mafalda , Willett Brian , Murcia Pablo R
Published: May 2022

Since the emergence of SARS-CoV-2, humans have been exposed to distinct SARS-CoV-2 antigens, either by infection with different variants, and/or vaccination. Population immunity is thus highly heterogeneous, but the impact of such heterogeneity on the effectiveness and breadth of the antibody-mediated response is unclear. We measured antibody-mediated neutralisation responses against SARS-CoV-2Wuhan, SARS-CoV-2α, SARS-CoV-2δ and SARS-CoV-2ο pseudoviruses using sera from patients with distinct immunological histories, including naive, vaccinated, infected with SARS-CoV-2Wuhan, SARS-CoV-2α or SARS-CoV-2δ, and vaccinated/infected individuals. We show that the breadth and potency of the antibody-mediated response is influenced by the number, the variant, and the nature (infection or vaccination) of exposures, and that individuals with mixed immunity acquired by vaccination and natural exposure exhibit the broadest and most potent responses. Our results suggest that the interplay between host immunity and SARS-CoV-2 evolution will shape the antigenicity and subsequent transmission dynamics of SARS-CoV-2, with important implications for future vaccine design.

Author Summary

Neutralising antibodies provide protection against viruses and are generated because of vaccination or prior infections. The main target of anti-SARS-CoV-2 neutralising antibodies is a protein called Spike, which decorates the viral particle and mediates viral entry into cells. As SARS-CoV-2 evolves, mutations accumulate in the spike protein, allowing the virus to escape antibody-mediated immunity and decreasing vaccine effectiveness. Multiple SARS-CoV-2 variants have appeared since the start of the COVID-19 pandemic, causing various waves of infection through the population and infecting-in some cases-people that had been previously infected or vaccinated. Since the antibody response is highly specific, individuals infected with different variants are likely to have different repertoires of neutralising antibodies. We studied the breadth and potency of the antibody-mediated response against different SARS-CoV-2 variants using sera from vaccinated people as well as from people infected with different variants. We show that potency of the antibody response against different SARS-CoV-2 variants depends on the particular variant that infected each person, the exposure type (infection or vaccination) and the number and order of exposures. Our study provides insight into the interplay between virus evolution and immunity, as well as important information for the development of better vaccination strategies.
GDF15 and ACE2 stratify COVID19 patients according to severity while ACE2 mutations increase infection susceptibility
Authors: Torrens-Mas Margalida , Perelló-Reus Catalina M , Trias-Ferrer Neus , Ibargüen-González Lesly , Crespí Catalina , Galmes-Panades Aina Maria , Navas-Enamorado Cayetano , Sanchez-Polo Andres , Piérola-Lopetegui Javier , Masmiquel Luis , Crespi Lorenzo Socias , Barcelo Carles , Gonzalez-Freire Marta
Published: May 2022

Coronavirus disease 19 (COVID-19) is a persistent global pandemic with a very heterogeneous disease presentation ranging from a mild disease to dismal prognosis. Early detection of sensitivity and severity of COVID-19 is essential for the development of new treatments. In the present study, we measured the levels of circulating growth differentiation factor 15 (GDF15) and angiotensin-converting enzyme 2 (ACE2) in plasma of severity-stratified COVID-19 patients and healthy control patients and characterized the in vitro effects and cohort frequency of ACE2 SNPs. Our results show that while circulating GDF15 and ACE2 stratify COVID-19 patients according to disease severity, ACE2 missense SNPs constitute a risk factor linked to infection susceptibility.
Less waste versus higher quality: how to stimulate consumer demand for frozen bread
Authors: van Herpen Erica , Jaegers Koen
Published: May 2022

Purpose

Bread waste is one of the largest contributors to the environmental footprint of supermarkets, mostly because of the short shelf life of fresh bread. This study examined a possible solution: offering frozen bread with a considerably longer shelf life. Professional freezing of bread can preserve its quality better than freezing at home. In introducing frozen bread, supermarkets can communicate either a high construal social benefit (food waste reduction) or a low construal personal benefit (product quality).

Design/methodology/approach

An online experiment (n = 367) with a three group between subjects design was used. Dutch participants saw an offering of frozen bread accompanied by (1) a communication message about food waste, (2) a communication message about product quality, or (3) no communication message (control condition).

Findings

In line with expectations, emphasizing food waste reduction influenced general attitudes toward frozen bread and the bakery department more strongly than the benefit of higher product quality, while the opposite was true for purchase intentions.

Practical implications

Retailers who include frozen bread in their assortment have to make a trade-off between especially stimulating consumer attitudes toward the bakery department by focusing on a food waste reduction message, or especially stimulating sales by focusing on a quality message.

Originality/value

This study provides new insights into the effects of benefit communication on attitudes and purchase intentions. The results show that these effects differ for attitudes and intentions, depending on the communication message.
A review of reverse logistics and closed-loop supply chains in the perspective of circular economy
Authors: Mishra Anurag , Dutta Pankaj , Jayasankar S. , Jain Priya , Mathiyazhagan K.
Published: May 2022

Purpose

This paper presents a systematic literature review of the various aspects of reverse logistics (RL) and closed-loop supply chains (CLSC) in implementing and achieving circular economy (CE) motives. CE is identified as a method of embracing imperishability into the economic structure, helping shift from a linear to a condition leading to ecological and social benefits.

Design/methodology/approach

Systematic literature was used to review a total of 80 peer-reviewed articles are included in the study and covers different concepts related to the implementation of CE, such as cost-saving, network design, sustainable RL, waste management and extended producer responsibility.

Findings

The findings reveal that the research in the domain is in a growing phase, and in recent years, a lot of attention has been given by researchers across the globe. However, further research is required in crucial areas for the adoption of CE, such as retail reverse logistics, pharmaceutical industries and resource recycling industry.

Practical implications

The study discusses the business needs and solutions for industries. Key enablers and barriers are listed along with the main activities involved in each sector in CLSC. Managers can design a pathway to decide which lever to use to overcome a particular challenge.

Originality/value

The work contributes theoretically by developing research themes in RL and CLSC practices applied to CE. It also provides theoretical and practical implications of the study, which can be used as a signboard for further research.
A systematic review of job-related diversity and future research directions
Authors: Yadav Shatrughan , Lenka Usha
Published: May 2022

Purpose

Job-related diversity is significantly different from demographic diversity, referring to diverse skills, knowledge, and perspectives. Despite the significant relevance of diversity literature, researchers have paid relatively less attention to job-related diversity dimensions like functional, educational, and tenure diversity. This study aims to analyze the scattered job-related diversity literature and identify mediating, moderating, and outcome variables, including dominant theories, methodological practices, and statistical techniques that affect performance outcomes.

Design/methodology/approach

This paper consolidates the job-related diversity literature and conducts a systematic review to fill the research gap. This study undertook a systematic review of 101 articles on job-related diversity published between 1991 and 2020 in academic management journals.

Findings

This study has synthesized several theoretical frameworks and proposed an integrative framework of job-related diversity for future research and theory development. Conclusively, this study has highlighted the gaps, advanced the knowledge in job-related diversity, and suggested future research avenues and implications.

Originality/value

This study is the first systematic review of job-related diversity, which acknowledges the importance of job-related diversity literature. Job-related diversity has received significant attention in the crisis-like situation during COVID-19 to develop innovative ideas and decision-making from different perspectives.
Supplier performance and selection from sustainable supply chain performance perspective
Authors: Meena Purushottam L. , Katiyar Rajesh , Kumar Gopal
Published: May 2022

Purpose

This paper aims to address the supplier selection problem based on a developed framework capturing the essence of the supply chain operations reference (SCOR) model, sustainability and providing services to customers. Specifically, the authors consider planning, manufacturing, delivery, sustainability and customer service attributes to evaluate and select suppliers.

Design/methodology/approach

Relevant literature is reviewed, a framework capturing the essence of major supply chain functions was developed and suitable measurement attributes were identified. An integrated fuzzy analytic hierarchy process and fuzzy technique for order performance by similarity to ideal solution method are employed to obtain the final ranking of the attributes and suppliers. The proposed methodology is illustrated through a real case of an Indian automobile company.

Findings

The authors observed that planning, manufacturing, customer service, sustainability and delivery are preferred in decreasing order to select component suppliers for an automotive company. The impact of suppliers on planning and manufacturing is most important to consider while assessing suppliers. Interestingly, concerns about sustainability and delivery are the least cared factors when selecting suppliers. The top five criteria contain measures of operational efficiency rather than purchasing cost.

Originality/value

This paper proposes and demonstrates a supplier selection framework harmonizing supply chain functions of the SCOR model, sustainability and customers service that adds a valuable wing to literature that expounds on the connection of purchasing strategy to corporate strategy. A case study in an automotive company throws unique and valuable managerial implications for purchasing and supply chain performance.
Does an abusive climate promote performance: an investigation of public sector hospitals of Pakistan
Authors: Tahir Zara , Bashir Fatima , Arshad Faria , Sabeen Zara
Published: May 2022

Purpose

This study aims to investigate the abusive supervision climate as an antecedent abusive supervision and attempts to uncover underlying mechanisms that affects employees' behavioural outcomes in terms of their performance.

Design/methodology/approach

A framework embedded in social learning theory is developed and empirically tested using a time-lag research design. Data have been collected from 330 functional dyads of supervisors and followers using judgement sampling (from public hospitals in Pakistan) that have been identified and matched for drawing analysis and inferences.

Findings

The results indicate that abusive supervision does occur because of the hypothesized precursor (abusive supervision climate) and that the underlying mechanisms (fear) delineated in this research positively and significantly affect performance of employees. The added significance of the study is its relevance for practitioners with opportunities to manage the factors affecting supervision and its relationship with employees' outcomes through appropriate interventions to improve the behavioural outcomes.

Social implications

The current study holds not only managerial and academic implications but also has economical and social implications. The findings of the study will help the supervisors and organisations understand how they become a source of their abusive behaviour. With the understanding of the root causes, they can encourage employees in developing mindfulness in recommendations which helps them build an internal capability to face external adversities. Policymakers will get insights into the underlying mechanisms of abusive supervision as well as problems they are facing with the employees. This understanding will help employers and employees in building internal control of employees improving their performance as well as mental health ultimately.

Originality/value

The study opens new avenues for further research with regard to the study of contextual, organisational and personal factors to mitigate abusive supervision as well as exploring additional moderators to lessen the relationship between abusive supervision and behavioural outcomes.
The public library as public sphere: a longitudinal analysis
Authors: Appleton Leo , Hall Hazel
Published: May 2022

Purpose

The research was undertaken to explore the role of the UK public library as a public sphere and the ways in which this role relates to the epistemic, community and political functions of public libraries.

Design/methodology/approach

A longitudinal, multi-location focus group approach was developed and deployed in three phases. Data were collected from 53 active public library users in a total of 24 focus groups conducted in eight different public library services in England and Scotland in 2015–2016 (Phase 1), 2016–17 (Phase 2) and 2017–18 (Phase 3). Data collected were transcribed and coded using NVivo 10- for thematic analysis.

Findings

The public library's role as public sphere aligns closely with its epistemic functions, adding a dimension to information services provision beyond access to “traditional” print and online sources. New information and knowledge emerge through the person-to-person interactions in public library space. Through such exchanges, the community function of public libraries is made evident, notably as a platform for citizens to participate actively in society, including its democratic processes.

Originality/value

Unlike much extant prior work on public library value dominated with accounts of societal and/or economic impact, w hich is frequently based on the analysis of quantitative data, here the fundamental epistemic value of public library services is demonstrated. This research also adds an important perspective to the domain of Information Society Studies where, to date, the place of the public library as public sphere has been treated as peripheral.