bluuebunny/crossref_metadata_2025 huggingface dataset:
Biometrical sexual differentiation of fourth, fifth and sixth lumbar vertebrae in blue bull (Boselaphus tragocamelus)
Authors: Sathapathy S. , Dhote B.S. , Mahanta D. , Tamilselvan S. , Mrigesh M. , Joshi S.K.
Published: November 2018

The present study was carried out on the lumbar vertebrae of adult Blue bull (Boselaphus tragocamelus) of either sex. Biometrical observations on different parameters of lumbar vertebrae reflected significance (P Less than 0.05) differences between the sexes of this species. It was confirmed that the average length of body gradually decreased from fourth to sixth lumbar vertebrae in the Blue bull. The average transverse diameter or width of vertebral canal and average vertical diameter or height of the vertebral canal was largest in the sixth lumbar vertebra. The average length of transverse process gradually increased from fourth to fifth lumbar vertebra and then it suddenly decreased in the sixth lumbar vertebra. The average height of the dorsal supraspinous process gradually decreased from fourth to sixth lumbar vertebrae and it was lowest in the sixth one. The data on the biometry of fourth, fifth and sixth lumbar vertebrae of Blue bull would develop a baseline that could be useful to the wild life Veterinarians in identification and solving vetero-legal cases.
Isolation and characterization of neural stem cells from ovine foetal cerebral cortex
Authors: Lija S. , Eswari S. , Monisha M. , Vijayarani K.
Published: November 2018

Neural stem cells are a potential source in cell based therapy for neurodegenerative diseases and traumatic brain injuries. The aim of this study is to isolate the ovine (Ovis aries) fetal neural stem cells and to analyze their neurogenic characteristics in vitro. Cerebral cortex pieces harvested from ovine fetal brain tissue were triturated for dispersal into single cells, cultured in neuronal stem cells culture medium and expanded in vitro in adherent culture. The morphological changes and the expression of neuron-specific gene markers and proteins were evaluated. These isolated NSCs were plastic adherent, self-renewing cells maintained the capacity to differentiate into brain specific cell types and they were found positive for neuronal stem cell markers, Nestin and â III tubulin by Reverse Transcription-PCR. Immunocytochemistry of the isolated NSCs also showed positive for Nestin, an established marker for neural and glial precursors as well as MSC marker CD90 and negative for hematopoietic CD34 markers.
De novo transcriptome analysis of differentially expressed genes in the liver of pampus argenteus under temperature stress
Authors: Shi Zhaohong , Liu Lei , Peng Shiming , Yue Yanfeng
Published: November 2018

Pampus argenteus is an aquatic cold-blooded animal, and its growth and survival are greatly affected by ambient temperature. During aquaculture, a sudden change in water temperature may be caused by climate change or other human factors, resulting in acute temperature stress. In this study, de novo transcriptome sequencing technology was used to analyze changes in the gene expressions in the liver of P. argenteus under temperature stress to understand the mechanisms of temperature regulation in P. argenteus. The results showed that 72447398, 69534310, 63698204, 78876728 and 53969050 clean reads were obtained from four cDNA libraries (A: 27°C (control group), B: 22°C and 6 h, C: 32°C and 6 h, D: 22°C and 12 h, E: 32°C and 12 h) of the P. argenteus by Illumina sequencing technology. In A\B, A\C, A\D and A\E pairwise comparison, 353, 431, 1303 and 343 differentially expressed genes (DEGs) were detected, respectively. Of these genes, 67 genes were identified among all the pairwise comparisons as the common DEGs. Four genes related to metabolic adaption to temperature were randomly selected to validate the DEGs results by real time PCR. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated some vital genes and pathways associated with metabolism in response to temperature challenge. These results will help us to understand the molecular mechanism underlying temperature regulation in P. argenteus and provide a theoretical basis for the study of related molecular mechanisms in fish under temperature stress.
Glucocorticoids change the transcript levels of galanin, galanin receptor-2 and brain-derived neurotrophic factor in rat hippocampal neurons
Authors: Pan Fangyan , Yang Chengying , Xie Qing , Yang Yang , Luo Xianmei , Gan Ling
Published: November 2018

Glucocorticoids (GCs) can affect hippocampal structure and function in animals and humans. This study was designed to investigate the possible functional molecules and mechanisms involved in the action of GCs on hippocampal neurons. Rat primary hippocampal neurons were cultured and treated with glucocorticoids at a low concentration (LC, 10-8 mol/L), a middle concentration (MC, 10-7 mol/L) and a high concentration (HC, 10-6 mol/L). The results indicate that GCs do not change the viability of hippocampal neurons but do change the catalase (CAT) activity and malondialdehyde (MDA) content. The transcription expression levels of brain derived neurotrophic factor (BDNF), galanin (GAL), galanin receptor-2 (GALR2), and neuropeptide Y receptor-5 (NPYR5) genes in the HC group were significantly higher than those in the control group (p less than 0.05). These results suggest that hippocampal neurons launch the neuron protection pathways mediated by GAL, GALR2 and BDNF molecules when encountering an experimentally high concentration of corticosteroids.
Effects of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol administration on free radical generation and blood gases in sheep
Authors: Gokalp E. , Gurgoze S. , Altan S.
Published: November 2018

This study was aimed at investigating the effects of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol combinations on oxidative stress, antioxidant capacity and blood gases in sheep. Excluding the control animals, the sheep included in Groups 1, 2 and 3 were administered with combinations of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol, respectively, by intravenous route. The comparison of the three treatment groups with the control group showed that no significant difference existed for TAS, TOS, MDA and CAT levels. The evaluation of blood gas and electrolyte levels demonstrated a significant decrease in PvO2, cSO2, Na, and Ca levels, and a significant increase in glucose levels. In result, this study showed that the three anaesthetic combinations tested did not have any adverse effect on the oxidant/antioxidant status, but caused significant alterations in blood gas levels.
Extensions of UML to Model Aspect-oriented Software Systems
Authors: Guessi Milena , Ruas Oliveira Lucas Bueno , Yumi Nakagawa Elisa
Published: November 2018

Aspect-Oriented Programming (AOP) has arisen as a new technology to support a better SoC (Separation of Concerns), intending to contribute to the development of reusable, maintainable, and evolvable software sys- tems. Aspects have been also explored in the early life cycle phases, aiming at contributing to a more adequate development of aspect-oriented software systems. In this perspective, in order to better represent these sys- tems, a diversity of extensions of the UML (Unified Modeling Language) has been proposed; however, there is a lack of a complete panorama that identify all these extensions. This paper presents an overview about which are possibly all extensions of the UML to represent aspect-oriented software systems. For this, we have used a technique proposed by Evidence-Based Software Engineering (EBSE): the Systematic Mapping. As achieved results, we can observe a diversity of work; however, there is not a consensus about which are the more adequate or more used extensions. Based on this overview, interesting and important perspectives for future research can also be found.
Collaboration Models in Distributed Software Development: a Systematic Review
Authors: C. Rocha Rodrigo G. , Costa Catarina , Rodrigues Cleyton , Ribeiro de Azevedo Ryan , Junior Ivaldir H. , Meira Silvio , Prikladnicki Rafael
Published: November 2018

Several years ago software development has become critical to the global market. In the past decade, as a reflection of globalization, software companies began to distribute their development processes in different places, creating distributed software development (DSD). With the growing of Distributed Software Development, organizations have attempt to sketch the best possible development structure, in order to improve productivity and quality. The aim of this paper is to present a Systematic Review of Literature to identify which ways of collaboration are commonly used by software organizations where teams are temporal and geographically dispersed, with also different native languages and culture. Further, the research was based on the basic life cycle of the traditional development, and where phases of the project are performed: onsite, distributed/offshore and multi-site. The systematic review have examined 868 papers published between 2000 and 2010.
OntoDiSENv1: an Ontology to Support Global Software Development
Authors: Chaves Ana Paula , Steinmacher Igor , Lapasini Leal Gislaine Camila , M. Huzita Elisa H. , Biasão Alberto B.
Published: November 2018

Global Software Development (GSD) brought competitive advantages to organizations, but it has also imposed some drawbacks due to the physical distribution. A critical aspect of this approach is related to communication. In order to provide the same semantic understanding about information exchanged on the environment to all team members it is necessary to minimize the ambiguity. This paper presents OntoDiSENv1, application ontology for a distributed software development environment. The goal of this ontology is support communication among geographically dispersed team members. The ontology is integrated to a contextual information dissemination model, which notifies the team members about the actions that occur on the shared workspace and can influence their work. The main contribution of OntoDiSENv1 is to support contextual information representation and processing, providing inference capability and semantic consistency of the information disseminated.
A Discrete Event Simulation Model for the Analysis of Software Quality Attributes
Authors: Bogado Verónica , Gonnet Silvio , Leone Horacio
Published: November 2018

A discrete event simulation model for evaluating quality attributes, employing the software architecture, is proposed in this work. A metamodel of the software architecture domain that includes the concepts required for measuring quality attributes at runtime is specified. So, a simulation model is built from it, following the principles of hierarchy and modularity, assembling simple blocks to obtain complex blocks. DEVS framework is applied to obtain a decoupled model from the simulator, and the DEVS formalism is used to specify the elements of the simulation model.

The objective of this approach is to provide information about the quality attributes that can be measured at runtime, introducing the discrete event simulation in the context of the software architecture design. This quantitative information will assist the architect to make decisions about the design of the system.
Is it Safe to Adopt the Scrum Process Model?
Authors: Hurtado Alegría Julio Ariel , Bastarrica María Cecilia , Bergel Alexandre
Published: November 2018

Scrum is a widely known agile software process model specifically designed for guiding non- technical activities in software development. This process has been formally defined in EPF and adopted by several software companies around the world. But having a process definition does not necessarily mean that it is well specified. We have developed AVISPA, a tool for localizing error patterns in software process models specified with EPF. In this paper, we analyze the public community specification of Scrum using AVISPA and we report our findings.
PRIORITY INDICATORS OF THE QUALITY OF LIFE OF PATIENTS WITH PRIMARY OPEN ANGLE GLAUCOMA AFTER SELECTIVE LASER TRAUBEKOPLASTICS
Authors: Chuprov A. D. , Kanyukov V. N. , Ekimov A. K. , Petrosyan E. A. , Kadnikova O. V.
Published: November 2018

This study used an approach to the estimation of changes in quality of life of patients after SLT surgery, based on the method of integral evaluation of the quality of life before and after surgery. These results allow us to determine the most priority questions of the questionnaire NEI-VFQ-25, which most strongly reflect changes in evaluation of quality of life of patients after SLT surgery.
GENDER AND AGE FEATURES OF DAILY DYNAMIC OF ARTERIAL BLOOD PRESSURE IN HEALTHY ADOLESCENTS 12-17 YEARS OLD
Authors: Sheveleva A. M. , Klauchek S. V.
Published: November 2018

The study shows gender and age features of the parameters of ambulatory blood pressure monitoring in adolescents 12-17 years old. Boys have higher level of 24-hour average, daytime average and night values of systolic blood pressure in all age-groups, relative higher variability of 24-hour average mean hemodynamic blood pressure at the age of 14-15 years and lower 24-hour average diastolic blood pressure at the age of 16-17 years in comparison with girls.
DETERMINATION OF THE FORM OF DISTAL OCCLUSION OF DENTAL ROWS BY THE METHOD OF COMPARATIVE ANALYSIS OF THE PARAMETERS OF THE CRANIO-FACIAL COMPLEX
Authors: Vologina M. V. , Fursik D. I. , Bavlakova V. V. , Litvinova A. A.
Published: November 2018

This article deals with the problem of distal occlusion. We have made the comparative analysis of the depth of gnatic part of the upper and lower face to indicate the form of this pathology The research has resulted into discovering that there is an anthropometric co-relation between the depth of gnatic part of the upper and lower face and the form of distal occlusion. In the most cases, the lack of correspondence of the depth of gnatic face parts was explained by normognatic upper jaw and micrognatic lower jaw.
CLINICAL EFFICACY OF ALTERNATIVE OPTIONS FOR BASIC THERAPY OF BRONCHIAL ASTHMA IN CHILDREN WITH CONCOMITANT MAGNESIUM DEFICIENCY
Authors: Perminov A. A. , Shishimorov I. N. , Nefedov I. V.
Published: November 2018

The efficacy of the basic pharmacotherapy of bronchial asthma in children may depend on the phenotype of the disease. In patients with concomitant magnesium deficiency the combination of inhaled glucocorticosteroids with leukotriene receptor antagonists was the most clinically effective. Correction of magnesium deficiency increased the effectiveness of a combination of inhaled glucocorticosteroids with long-acting β2-agonists.
THE VALUE OF PREFORMED FACTORS IN THE RECOVERY OF VEGETATIVE REGULATION OF PATIENTS WITH INFLAMMATORY DISEASES OF THE PELVIC ORGANS
Authors: Burova N. A. , Zharkin N. A. , Klauchek S. V. , Lemaykina E. V. , Barinova I. A. , Frolova A. S.
Published: November 2018

Color-pulse exposure improves emotional state of patients with inflammatory diseases of the pelvic organs, reducing personal and reactive anxiety. The inclusion in complex treatment of patients with inflammatory diseases of the pelvic organs color-pulse therapy of helps to restore the function of the vegetative and central nervous system.
CURRENT STATE OF THE PROBLEM OF OVERWEIGHT AND OBESITY IN WOMEN
Authors: Tkachenko L. V. , Sviridova N. I. , Skladanovskaya T. V.
Published: November 2018

The article surveys the generalized and systemized modern data on the influence of the changes in neuroendocrine regulation of hydrocarbonate and lipid metabolism on women's reproductive function and developing of gynecological diseases.
REMOVAL ALLOY CAST ROOT INLAY BY LOWPOWER ULTRASONIC AND STANDARD TIP
Authors: Vejsgejm L. D. , Gomenjuk T. N.
Published: November 2018

7 drawn molded cast root inlay using an ultrasonic apparatus with low power use of standard tip. Treatments were applied with a constant copious water-cooled maximum power ultrasound. The length of a visit to the construction of extraction ranged from 30 to 40 minutes. It took 2 to 6 visits without anesthesia. Satisfaction with the results of the treatment compensates for the time required to motivate and technical re-equipment.
ASSESSMENT OF EFFICACY AND THE NEAREST RESULTS OF ENDOVENOUS LASER COAGULATION IN THE COMPREHENSIVE TREATMENT OF SEVERE VARICOSE VEINS
Authors: Savinov I. S. , Ilchenko F. N. , Butyrskii A. G. , Saviniv S. G. , Matveyeva N. V. , Kalachyov Ye. V.
Published: November 2018

The paper describes our approaches to miniinvasive treatment of severe varicose veins of clinical classes С4-6. One shows that in 2 months after interventions there is no evidence between the patients groups in recanalizations and side effects, all analyzed outcomes in certain parameters of EVLC satisfactory. In varicose veins C4-6, and SFJ size less 20 mm it's expedient to perform EVLC without crossectomy. If SFJ above 20 mm, or wellhead aneurysms it's expedient to combine EVLC with crossectomy Performing EVLC causes TU healing in 75 % of cases during nearest 2 months after correction of phlebohaemodynamics.
CEREBROPROTECTIVE ACTIVITY OF C-38 - DERIVATIVE HYDROXYBENZOIC ACID IN RATS WITH BILATERAL COMMON CAROTID ARTERY OCCLUSION
Authors: Arslanbekova V. A. , Verkholyak D. V. , Kurkin D. V. , Bakulin D. A. , Atapina N. V. , Brel A. K. , Lisina S. V.
Published: November 2018

The effect of a new hydroxybenzoic acid derivative was studied in rats with bilateral common carotid artery occlusion (BCAO). Mortality, neurological and behavioral deficiency was assessed within 72 hours after BCAO. Preventive C-38 administration (9 mg/kg) resulted in decrease in mortality (by 32 %) and severity of neurologic deficit (by 38 %) compared with the control group treated with vehicle. C-38 administration promoted increase of locomotor activity in the Open Field test, as well as the memory preservation in the active and passive avoidance tests in animals with brain ischemia. The cerebroprotective activity of C-38 was comparable to the citicoline.
THE PREVALENCE AND NATURE OF DENTOALVEOLAR ANOMALIES IN CHILDREN LIVING IN KRASNODAR AND IN SOME TERRITORIES OF KRASNODAR REGION
Authors: Voskanyan A. R. , Ayupova F. S. , Zobenko V. J. , Alekseenko S. N.
Published: November 2018

According to the results of studies of the state of dental health of children living on the territory of the Russian Federation and abroad, the most common conditions include dentoalveolar anomalies (DAA). It is claimed that the prevalence of children with DDA in recent decades has increased from 50 % to 65-70 % and does not tend to decrease. At the same time, most authors study the prevalence of DDA in general and some of their varieties. Less they study the prevalence of certain types of anomalies and do not pay attention to a more detailed characterization of the dental arches and their correlation, which is decisive in the planning of therapeutic and prophylactic measures. Insufficiently studied orthodontic pathology in Krasnodar and the Krasnodar Territory, which was the reason for this study.
ANALYSIS OF THE HISTOMORPHOLOGICAL CONDITION OF THE CORNEA IN THE USE OF ORTOKERATOLOGICAL LENSES
Authors: Ezhova E. A. , Melikhova I. A. , Balalin S. V.
Published: November 2018

Present work describes the study of the histomorphological status of the cornea in the central optical, middle peripheral and perilimbal zone using confocal microscopy (ConfoScan - 4) 72 patients (144 eyes) with myopia of a weak (38 people, 76 eyes) and moderate (34 persons, 68 eyes) after the appointment of OKL within 1 to 12 months. Presented the results of the histomorphological indices made it possible to single out a «stressful» period of adaptation lasting 1 month, a transitional period of 1 to 3 months, and a stable adaptation period, the formation of which was noted by 12 months of the application of OKL. Stable densities of keratocytes in various layers of the corneal stroma, endothelial cells during the entire period of observation indicated a fairly good tolerability of OKL.
FEATURES OF PATHOGENESIS OF SENSORINEURAL HEARING LOSS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Mazikina D. A. , Kotova S. M. , Matezius I. Yu. , Khetagurova F. K.
Published: November 2018

The article presents results of clinical and special audiological assessment of 191 women with type 2 diabetes mellitus. Data demonstrate that sensorineural hearingloss development is determined by acceleration of presbycusis pathogenetic processes.
Linear or non Linear modeling for ENSO dynamics?
Authors: Bianucci Marco , Capotondi Antonietta , Mannella Riccardo , Merlino Silvia
Published: November 2018

Observed ENSO statistics exhibits a non-gaussian behavior, which is indicative of the presence of nonlinear processes. In this paper we use the Recharge Oscillator model (ROM), a largely used Low-Order Model (LOM) of ENSO, as well as methodologies borrowed from the field of statistical mechanics to identify which aspects of the system may give rise to nonlinearities that are consistent with the observed ENSO statistics. In particular, we are interested in understanding whether the nonlinearities reside in the system dynamics or in the fast atmospheric forcing. Our results indicate that one important dynamical nonlinearity often introduced in the ROM cannot justify a non-gaussian system behavior, while the nonlinearity in the atmospheric forcing can instead produce a statistics similar to the observed. The implications of the non-Gaussian character of ENSO statistics for the frequency of extreme El Nino events is then examined.
Economic Multiple Model Predictive Control for HVAC Systems - A Case Study for a Food Manufacturer in Germany
Authors: Heidrich Tobias , Grobe Jonathan , Meschede Henning , Hesselbach Jens
Published: November 2018

The following paper describes an economical, multiple model predictive control (EMMPC) for an air conditioning system of a confectionery manufacturer in Germany. The application consists of a packaging hall for chocolate bars, in which a new local conveyor belt air conditioning system is used and thus the temperature and humidity limits in the hall can be significantly extended. The EMMPC calculates the optimum energy or cost humidity and temperature set points in the hall. For this purpose, time-discrete state space models and an economic objective function with which it is possible to react to flexible electricity prices in a cost-optimised manner are created. A possible future electricity price model for Germany with a flexible EEG levy was used as a flexible electricity price. The flexibility potential is determined by variable temperature and humidity limits in the hall, which are oriented towards the comfort field for easily working persons, and the building mass. The building mass of the created room model is used as a thermal energy store. Considering electricity price and weather forecasts as well as internal, production plan-dependent load forecasts, the model predictive controller directly controls the heating and cooling register and the humidifier of the air conditioning system.
Nonlocal Symmetries for Time-Dependent Order Differential Equations
Authors: Ludu Andrei
Published: November 2018

A new type of ordinary differential equation is introduced and discussed, namely, the time-dependent order ordinary differential equations. These equations can be solved via fractional calculus and are mapped into Volterra integral equations of second kind with singular integrable kernel. The solutions of the time-dependent order differential equations smoothly deforms solutions of the classical integer order ordinary differential equations into one-another, and can generate or remove singularities. An interesting symmetry of the solution in relation to the Riemann zeta function and Harmonic numbers was also proved.
A Review of Geological Applications of High-Spatial-Resolution Remote Sensing Data
Authors: Wu Chunming , Li Xiao , Chen Weitao , Li Xianju
Published: November 2018

Geologists employ high-spatial-resolution (HR) remote sensing (RS) data for many diverse applications as they effectively reflect detailed geological information, enabling high-quality and efficient geological surveys. Applications of HR RS data to geological and related fields have grown recently. By analyzing these applications, we can better understand the results of previous studies and more effectively use the latest data and methods to efficiently extract key geological information. HR optical remote sensing data are widely used in geological hazard assessment, seismic monitoring, mineral exploitation, glacier monitoring, and mineral information extraction due to high accuracy and clear object features. Compared with optical satellite images, synthetic-aperture radar (SAR) images are stereoscopic and exhibit clear relief, strong performance, and good detection of terrain, landforms, and other information. SAR images have been applied to seismic mechanism research, volcanic monitoring, topographic deformation, and fault analysis. Furthermore, a multi-standard maturity analysis of the geological applications of HR images using literature from the Science Citation Index reveals that optical remote sensing data are superior to radar data for mining, geological disaster, lithologic, and volcanic applications, but inferior for earthquake, glacial, and fault applications. Therefore, geological remote sensing research needs to be truly multidisciplinary or interdisciplinary, ensuring more detailed and efficient surveys through cross-linking with other disciplines. Moreover, the recent application of deep learning technology to remote sensing data extraction has improved automatic processing and data analysis capabilities.
Sensory Neuromodulation
Authors: Black Robert D. , Rogers Lesco L.
Published: November 2018

We describe a model of neurological disease based on dysfunctional brain oscillators.  This is not a new model, but it is not one that is generally appreciated by clinicians.  The value of this model lies in the predictions it makes and the utility it provides in translational applications, in particular for neuromodulation devices.  We provide a perspective on the difference between neuromodulation devices that enforce an externally administered stimulus with devices that provide input to sensory receptors and thus stimulate endogenous sensory networks.  Current forms of clinically applied neuromodulation are of the former type, including devices such as (implanted) deep brain stimulators (DBS) and various, noninvasive methods such as transcranial magnetic stimulation (TMS) and transcranial current methods (tACS, tDCS).  The challenge with these methods is that they are not sensitive to underlying neuronal dynamics and work by applying an empirically derived electrical current waveform to affect dynamical patterns. Neuromodulation of a sensory organ accesses the same pathways that natural environmental stimuli do and, importantly, the modulatory signal will be transformed as it travels through the brain, allowing the modulation input to be consistent with regional dynamics.  We present specific examples of devices that rely on sensory neuromodulation and evaluate the translational potential of these approaches.  We argue that sensory neuromodulation is well suited to probe and, ideally, repair dysfunctional brain oscillators, thus providing a novel therapeutic approach for neurological diseases.
A-to-I RNA Editing Affects lncRNAs Expression after Heat Shock
Authors: Haas Roni , Ganem Nabeel S. , Keshet Ayya , Orlov Angela , Fishman Alla , Lamm Ayelet T.
Published: November 2018

Adenosine to inosine (A-to-I) RNA editing is a highly conserved regulatory process carried out by adenosine-deaminases (ADARs) on dsRNAs. Although a considerable fraction of the transcriptome is edited, the function of most editing sites is unknown. Previous studies indicate changes in A-to-I RNA editing frequencies following exposure to several stress types. However, the overall effect of stress on the expression of ADAR targets is not fully understood. Here, we performed high-throughput RNA sequencing of wild-type and ADAR mutant C. elegans worms after heat-shock to analyze the effect of heat-shock stress on the expression pattern of genes. We found that ADAR regulation following heat-shock does not directly involve heat-shock related genes. Our analysis also revealed that lncRNAs and pseudogenes, which have a tendency for secondary RNA structures, are enriched among upregulated genes following heat-shock in ADAR mutant worms. The same group of genes is downregulated in ADAR mutant worms under permissive conditions, which is likely, considering that A-to-I editing protects endogenous dsRNA from RNA-interference (RNAi). Therefore, temperature increases may destabilize dsRNA structures and protect them from RNAi degradation, despite the lack of ADAR function. These findings shed new light on the dynamics of gene expression under heat-shock in relation to ADAR function.
Modified Ethylsilicates as Efficient Innovative Consolidants for Sedimentary Rock
Authors: Remzova Monika , Carrascosa Luis Antonio Martinez , Mosquera Maria Jesus , Rathousky Jiri
Published: November 2018

Even if silicon alkoxides (especially ethylsilicates) have long been used as consolidants of weathered stone monuments, their physical properties are not ideal. In this study, an innovative procedure for the consolidation of sedimentary rocks was developed that combines the use of organometallic and alkylamine catalysts with the addition of well-defined nanoparticles exhibiting a narrow size distribution centered at ca 10 nm. As a suitable test material, the Pietra di Lecce limestone was selected because of its color and problematic physico-chemical properties, such as rather low hardness. Using the developed procedure, the mechanical and surface properties of the limestone were improved without the unwanted over-consolidation of the surface layers of the stone, and any significant deterioration in the pore size distribution, water vapor permeability or the stone’s appearance. The developed modified ethylsilicates penetrated deeper into the pore structure of the stone than the unmodified ones and increased the hardness of the treated material. The formed xerogels within the stone pores did not crack. Importantly, they did not significantly alter the natural characteristics of the stone.
Study of the Effect of Inorganic Particles on the Gas Transport Properties of Glassy Polyimides for Selective CO2 and H2O Separation
Authors: Escorihuela Sara , Valero Lucia , Tena Alberto , Shishatskiy Sergey , Escolastico Sonia , Brinkmann Torsten , Serra Jose Manuel
Published: November 2018

Three polyimides and six inorganic fillers in a form of nanometer-sized particles were studied as thick film solution cast mixed matrix membranes (MMMs) for transport of CO2, CH4 and H2O. Gas transport properties and electron microscopy images indicate good polymer-filler compatibility for all membranes. The only filler type which demonstrated good distribution throughout the membrane thickness at 10 wt. % loading was BaCe0.2Zr0.7Y0.1O3 (BCZY). The influence of this filler on MMM gas transport properties was studied in detail for 6FDA-6FpDA in a filler content range from 1 to 20 wt.% and for Matrimid® and P84® at 10 wt. % loading. The most promising result was obtained for Matrimid® - 10wt% BCZY MMM, which showed improvement in CO2 and H2O permeabilities accompanied by increased CO2/CH4 selectivity and high water selective membrane at elevated temperatures without H2O/permanent gas selectivity loss.
A Comparison Study on Criteria to Select the Most Adequate Weighting Matrix
Authors: Herrera Marcos , Mur Jesús , Ruiz Marín Manuel
Published: November 2018

The practice of spatial econometrics revolves around a weighting matrix, which is often supplied by the user on previous knowledge. This is the so called $\mathbf{W}$ issue. Probably, the aprioristic approach is not the best solution although, nowadays, there few alternatives for the user. Our contribution focuses on the problem of selecting a $\mathbf{W}$ matrix from among a finite set of matrices, all of them considerer appropriate for the case. We develop a new and simple method based on the Entropy corresponding to the distribution of probability estimated for the data. Other alternatives, which are common in current applied work, are also reviewed. The paper includes a large Monte Carlo to calibrate the effectiveness of our approach compared to the others. A well-known case study is also included.
The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis
Authors: de França Elias , Lira Fábio Santos , Ruaro Marcio Flávio , Hirota Vinicius Barroso , Faria Waziry Paula A. , Fukushima André Rinaldi , Miranda Maria Luiza de Jesus , Caperuto Erico Chagas
Published: November 2018

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect beta-alanine (BA) or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018.  A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, BA/carnosine supplementation increased total antioxidant capacity (TAC) and glutathione concentrations while decreased pro-oxidant markers and superoxide dismutase (SOD) activity. BA or carnosine supplementation did not prevent the increase in peroxidation markers (e.g., 8-isoprostane, protein carbonyl or malonaldehyde). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.
Influence of Gradual Damage on the Structural Dynamic Behaviour of Composite Rotors: Experimental Investigations
Authors: Filippatos Angelos , Gude Maik
Published: November 2018

Fibre-reinforced composite structures under complex loads exhibit gradual damage behaviour with a degradation of effective mechanical properties and change of their structural dynamic behaviour. Damage manifests itself as spatial increase of inter-fibre failure and delamination-growth, resulting in local changes of stiffness. These changes affect not only the residual strengths but more importantly the structural dynamic behaviour. In case of composite rotors, this can lead to catastrophic failure if an eigenfrequency coincides with the rotational speed. The description and analysis of the gradual damage behaviour of composite rotors therefore provides the fundamentals for a better understanding of unpredicted structural phenomena. The gradual damage behaviour on the example of composite rotors and the resulting damage-dependent dynamic behaviour is experimentally investigated under propagating damage for combined out-of-plane and in-plane loads. A novel observation is reported, where monotonic increase of damage results in non-monotonic frequency shift of significant amount of eigenfrequencies.
Interconnecting Haptic Interfaces through The Internet
Authors: Kokkonis George , Psannis Kostas E. , Kontogiannis Sotirios , Nicopolitidis Petros , Roumeliotis Manos , Ishibashi Yutaka
Published: November 2018

Supermedia streams transfer video, audio, haptic and other sensory data. Real -time transfering of supermedia streams over the Internet is quite challenging. This paper outlines the proposed protocols for transferring supermedia streams over the Internet. Moreover, it describes the Quality of Service (QoS) requirements for supermedia applications that a network has to fulfill. Extensive simulations and experiments for the performance evaluation of transport protocols for real time transferring HEVC streams with supermedia data are carried out. Complements, differences and relevancies between simulation and real world experiments are discussed. The metrics that are measured for the performance evaluation are delay, jitter, throughput, efficiency, packet loss and one proposed by the authors, packet arrival deviation. The simulation tests reveal which protocols could be used for the transfer of real-time supermedia data with a HEVC video stream.
Sustainable Development and Tourist Satisfaction in Historical Districts: Influencing Factors and Mechanisms
Authors: Yu Wenting , Liu Jiaming , Zhang Shuying , Li Tao
Published: November 2018

How to achieve sustainable development and protection of historical district is a worthwhile research topic. As a vital way to update urban space, tourism development in historical district is an effective solution to redistribute urban functions and increase urban vitality. This paper takes the Insadong in South Korea as a case to carry out the evaluation of tourist satisfaction in historical districts. The research finds that: 1) The tourist satisfaction evaluation of Insadong includes 6 dimensions in total, namely “Embodiment of historical elements”, “The blend of tradition and modernity”, Industry distribution and type", "Consumer demand", "Street layout and function", "Landscaping". The most satisfying for tourists is "Landscaping", and the most dissatisfying is "Street layout and function". 2) “The blend of tradition and modernity” has the highest weight while “Industry distribution and type” has the lowest one in the analysis of influencing factors on overall satisfaction. 3) The analysis of the common factor weight and the common factor satisfaction shows that “The blend of tradition and modernity” and “Street layout and function” are the parts that need to be improved. “Consumer demand” also has a lot of room for promotion. The research results will benefit to enhance the tourist experiences of historical district and provide theoretical basis and practical experience reference for effective protection and sustainable development of historical district.
Leaching of Lead and Copper by Citric Acid from Direct-to-Blister Copper Flash Smelting Slag
Authors: Gargul Krzysztof , Jarosz Piotr , Małecki Stanisław
Published: November 2018

Direct-to-blister copper flash smelting slag contains up to 14% of copper and 2-4% of lead. Considering this fact, this material is subjected to the high-temperature reduction process. After this, converting process is performed on the Cu-Pb-Fe alloy being the product of decopperization process in electric furnace. An alternative to the presently used processing of flash smelting slag would be its hydrometallurgical treatment and selective recovery of Pb and Cu. This paper presents the results of laboratory tests on flash smelting slag leaching with citric acid solutions. The experiments performed allowed to determine the process parameters at which the Pb concentration in the post-leaching sediment reached the value of 0.41-0.6% while the Pb content in flash smelting slag was 3.05%. Analogous values for copper were 11.5-11.8% (after leaching) and 12.44% (before). Material after leaching in citric acid solutions can be processed, in the second step, using sulfuric acid solutions, and it could lead to the recovery of almost all copper contained in it.
The Correspondence Principle in Quantum Field Theory and Quantum Gravity
Authors: Anselmi Damiano
Published: November 2018

We discuss the fate of the correspondence principle beyond quantum mechanics, specifically in quantum field theory and quantum gravity, in connection with the intrinsic limitations of the human ability to observe the external world. We conclude that the best correspondence principle is made of unitarity, locality, proper renormalizability (a refinement of strict renormalizability), combined with fundamental local symmetries and the requirement of having a finite number of fields. Quantum gravity is identified in an essentially unique way. The gauge interactions are uniquely identified in form. Instead, the matter sector remains basically unrestricted. The major prediction is the violation of causality at small distances.
Is the External Audit Report Useful for Bankruptcy Prediction? Evidence Using Artificial Intelligence
Authors: Muñoz-Izquierdo Nora , Camacho-Miñano María-del-Mar , Segovia-Vargas María Jesús , Pascual-Ezama David
Published: November 2018

Despite the number of studies on bankruptcy prediction using financial ratios, very little is known about how external audit information can contribute to anticipating financial distress. A handful of papers show that a combination of ratios and audit data can provide significant predictive purposes, but a recent paper by Muñoz-Izquierdo et al. (2018) provided an 80% predictive accuracy solely by using the disclosures of audit reports. We complement this study. Applying an artificial intelligence method (the PART algorithm), we examine the predictive ability of more easily extracted information from the report and suggest a practical implication for each user. Simply by (1) finding the audit opinion, (2) identifying if a matter section exist, (3) and the number of comments disclosed, then any user may predict a bankruptcy situation with the same accuracy as if they had scrutinised the whole report. In addition, we also provide an extended literature review about previous studies on the interaction between bankruptcy prediction and the external audit information.
Synchronized Molecular-Dynamics Simulation of the Thermal Lubrication of an Entangled Polymeric Liquid
Authors: Yasuda Shugo
Published: November 2018

The thermal lubrication of an entangled polymeric liquid in wall-driven shear flows between parallel plates is investigated by using a multiscale hybrid method coupling molecular dynamics and the hydrodynamics (i.e., the synchronized molecular dynamics method).
The temperature of the polymeric liquid rapidly increases due to viscous heating once the drive force exceeds a certain threshold value.
The rheological properties of the polymeric liquid drastically change at around the critical drive force.
In the weak viscous-heating regime, the conformation of polymer chains is dominated by the local shear flow so that the anisotropy of the bond orientation tensor grows as the drive force increases.
However, in the large viscous-heating regime, the conformation dynamics is dominated by the thermal agitation of polymer chains so that the bond orientation tensor recovers more uniform and random structures as the drive force increases, even though the local shear flows are further enhanced.
Remarkably, these counter-intuitive transitional behaviors give an interesting re-entrant transition in the stress--optical relation, where a linear formalism in the stress--optical relation approximately holds even though each of the macroscopic quantities behaves nonlinearly.
The robustness of the linear stress--optical relation is also confirmed in the spatiotemporal evolution at the hydrodynamic level.
Determinants of Smallholder Teff Farmers’ Market Participation; A Case Study In Gena-Bossa District, Dawro Zone, Ethiopia
Authors: Dalango Deresse , Mulugeta Wondaferhu , Melaku Tesfaye
Published: November 2018

Increasing market participation among smallholder farmers have a big potential to uplift living standards of poor through increasing production and consumption pattern. Although, smallholder farming made 95% of total crop production in Ethiopia, they are exposed to a marketing bottleneck that hinders benefits from their produce. The objective of this study was analyzing factors determining smallholder Teff farmer decision to participate in output market and level of marketed output.The study used data from 190 respondents from four selected Teff dominant kebeles of Gena-Bossa districts in Dawro Zone, through structured questioner. This investigation was imperative because no adequate research has been done in study area in examining the hindering factors of farmers’ market participation. Moreover, in the prior study, different authors come up with varied outcomes in diverse country and geographic location concerning poor farmers’ market participation decision. The descriptive statistics and Heckman two stage econometric methods were employed to analyze data collected from sampled household. The significance of coefficient of inverse Mill’s ratio ( ) indicates the presence of self-selection bias and the effectiveness of applying Heckman two stage model. The results of study show that the smallholder decision to participate in output market were positively influenced by size of land holding, availability of family labor force, education status of household head, accessibility of credit service and access to market price information. On the other hand, size of family member, sex of house hold head being female and distance to market place discourage probability of Teff farmer market participation decision. Moreover, the second stage estimation reveals that, the education status of house hold head, size of farm land, amount of Teff crop produced, accessibility of market information, the size of family labor force and being member to farm cooperative increase the quantity of marketable output, whereas, large number of family size decline the level of Teff crops marketed. The policy that assist poor farmers in obtaining market skills; create affordable credit service; strengthen community based producer groups and capacitating the females socially and economically in the community believed to minimize the problems encountering small farmers in a way to market their crop
Symmetries among Multivariate Information Measures Explored Using Möbius Operators
Authors: Galas David J. , Sakhanenko Nikita A.
Published: November 2018

Information-related measures are useful tools for multi-variable data analysis, as measures of dependence among variables, and as descriptions of order and disorder in biological and physical systems.  Measures, like marginal entropies, mutual / interaction / multi -information, have long been used in a number of fields including descriptions of systems complexity and biological data analysis.  The mathematical relationships among these measures are therefore of significant inherent interest.  Relations between common information measures include the duality relations based on Möbius inversion on lattices.  These are the direct consequence of the symmetries of the lattices of the sets of variables (subsets ordered by inclusion).  While these relationships are of significant interest there has been, to our knowledge, no systematic examination of the full range of relationships of this diverse range of functions into a unifying formalism as we do here.  In this paper we define operators on functions on these lattices based on the Möbius inversions that map functions into one another (Möbius operators).  We show that these operators form a simple group isomorphic to the symmetric group S3.  Relations among the set of functions on the lattice are transparently expressed in terms of the operator algebra, and, applied to the information measures, can be used to derive a wide range of relationships among diverse information measures.  The Möbius operator algebra is naturally generalized which yields extensive new relationships.  This formalism now provides a fundamental unification of information-related measures, and the isomorphism of all distributive lattices with the subset lattice implies an even broader application of these results.