bluuebunny/crossref_metadata_2025 huggingface dataset:
PRDM16 deficiency triggered by TGF-β signaling aggravated renal fibrosis by promoting tubular mitochondrial dysfunction
Authors: yuan qian , tang ben , Wan Chao , Xie Ya-Ru , Xie Yajuan , zhu yuting , Su Hua , Zhang Chun
Published: December 2022

TGF-β signaling is the master modulator of renal fibrosis. However, its targeting drugs are failed to prevent the progression of chronic kidney disease (CKD) in clinical trials due to the extensive biological regulation of TGF-β signaling. It is necessary to investigate the precise downstream of TGF-β signaling that regulates renal fibrosis. In this study, we found that transcription factor PRDM16 expressed by human renal tubular epithelial cells was reduced markedly by TGF-β. Mechanistically, the activated Smad3 induced by TGF-β interacted with the cofactor, H-Ras, and bound to the promoter of PRDM16 to downregulate its transcription. Tubular-specific knockout of PRDM16 promoted renal fibrosis of unilateral ureteral occlusion (UUO) and unilateral ischemia-reperfusion injury (UIRI) mice by aggravating mitochondrial dysfunction.In vitro, PRDM16 blocked TGF-β-induced mitochondrial injury, and lipid deposition by upregulating PGC-1α. PRDM16 supplementary therapy preserved renal function and ameliorated the progression of renal fibrosis by protecting mitochondrial function. We report a novel downstream of TGF-β signaling, PRDM16 for attenuating renal fibrosis by protecting tubular mitochondrial function.
Lymphoma OR Brucellosis: a Case Series Study
Authors: Rostami Parsa , Shabani Shiva , Fattahi Fahimeh
Published: December 2022

Background: As a zoonotic disease, human brucellosis has a wide variety of clinical manifestations, ranging from multisystem involvement to asymptomatic infection.
Case Presentation: Cases with hematological abnormalities and lymphadenopathies at a referral unit to a cancer hospital from September 2021 to August 2022 were described. Follow-up and clinical symptoms led to brucellosis being diagnosed.
Conclusion: Exist of lymphadenopathies associated with hematological abnormalities led to challenges in our diagnosis, especially the observation of mesenteric and retroperitoneal lymphadenopathies. A proper diagnosis and treatment for brucellosis lead to the complete resolution of lymphadenopathies. As far as we know from the literature, the association of rare symptoms with typical symptoms of brucellosis may be very confusing and delay the diagnosis. Therefore, these case reports can highlight symptoms of brucellosis that mimic a primary hematologic disorder for better and faster diagnosis.
Impact of primary glaucoma on Health-Related Quality of Life in China： The Handan Eye Study
Authors: Song Di , Fan Sujie , Zhou Qiang , Yang Xiaohui , Li Sizhen , Lohfeld Lynne , Zhou Weihe , Congdon Nathan , Liang Yuanbo , Wang Ningli
Published: December 2022

Objectives: To assess health-related quality of life (HRQOL) by EQ-5D among glaucoma patients in the Handan Eye Study (HES), as well as the factors that influence the quality of life.
Methods: A central clinic in the county hospital, a temporary clinic in the targeted villages, or at the participant’s home. The Handan Eye Study (HES) is a population-based prevalence study of eye disease in rural Yongnian County, northern China. A total of 99 adults with glaucoma were enrolled for analysis, including 67 with primary open-angle glaucoma (POAG) and 32 with primary angle-closure glaucoma (PACG). And 256 selected people with better visual acuity and visual field but Without Primary Glaucoma. Results of ophthalmic examinations and socio-economic information were recorded. HRQOL was measured using the EQ-5D, and visual function (VF) and vision-related quality of life (VRQOL) were evaluated using a Visual function-quality of life (VF-QOL) instrument.
Primary and secondary outcome measures: EQ-5D and VF-QOL score.
Results： The mean ± standard deviation (SD) scores on the EQ-5D, VF, and VRQOL for the 99 glaucoma cases were 0.98±0.04, 87.9±15.2, and 95.5±12.8 respectively. Utility values were significantly lower among participants with glaucoma (0.98±0.04) compared to those without (0.99±0.02, P = 0.008), even after adjusting for age, gender, education level, family income, and comorbidity (P = 0.02). There was a significantly lower utility value (0.92±0.08) among patients with lower VRQOL total score (55.4 ± 11.5) compared to higher (0.99 ± 0.03, P = 0.036), even after adjustment for age and family income (P = 0.006).
Conclusion: Patients with glaucoma, particularly those with poor VRQOL, exhibited lower HR-QOL than those without. Early diagnosis and prevention facilitated by government health insurance may enhance VF-QOL for glaucoma patients, especially for PACG.
Can We Predict Gastric Leaks after Laparoscopic Sleeve Gastrectomy by Evaluating the Complete Blood Count on Postoperative Day One?
Authors: Seyit Hakan , Alis Halil
Published: December 2022

Background: We assessed whether postoperative day-1(POD-1) complete blood count(CBC) test parameters, including red cell distribution width(RDW), mean platelet volume(MPV), plateletcrit(PCT), platelet-to-lymphocyte ratio(PLR), and neutrophil-to-lymphocyte ratio(NLR), could identify patients with gastric leaks after laparoscopic sleeve gastrectomy(LSG).
Methods: Patients with postoperative gastric leaks(n=36) and patients with no complications that were selected by age-sex-BMI matching(n=254) were included into the study. The levels of RDW, MPW, PCT, PLR, and NLR were compared between groups in univariate analyses. Receiver operating characteristic(ROC) curve analysis was run for CBC parameters with a p-value<0.05 in univariate analyses. The area under the curve(AUC) was evaluated, and a cut-off value was determined. Sensitivity, specificity, likelihood ratio(LR), positive predictive value(PPV), negative predictive value(NPV), and accuracy were calculated.
Results: The level of PCT was significantly lower while levels of PLR and NLR were significantly higher in patients with postoperative gastric leaks as compared to those without(p<0.05). The AUC of both PCT and PLR was less than 0.750, while the AUC of NLR was 0.911. NLR cut-off at 3.6 yielded 80% sensitivity, 92% specificity, and LR of 10. In the study cohort, PPV of 59%, NPV of 97%, and an accuracy of 90% were found.
Conclusions: Our results suggest that NLR at POD-1, with a cut-off value of 3.6, is a useful indicator of postoperative gastric leak who underwent LSG. We recommend the use of this easily calculated parameter in clinical practice.
Elastofibroma Dorsi: Demographic, Clinical and Radiological Assessment
Authors: Samimi Kaveh , Hakim Peyman Kamali , Zeinalkhani Hadise , Ahmadinejad Nasrin , Zeinalkhani Fahimeh , Delazar Sina
Published: December 2022

Background: Elastofibromadorsi is an uncommon benign pseudotumor. We aimed to assess its demographic, clinical and radiological features.
Materials and methods: We retrospectively re-evaluated all thoracic CT scans and MRI's of Babak imaging center to identify cases of elastofibromadorsi. Such variables as age, gender, weight, height, body mass index, handedness, and symptoms were extracted from their medical records. Hounsfield numbers and mass laterality were determined by three radiologists. Also, suspicious patients were asked to undergo punch biopsies. Data were analyzed using SPSS software.
Results: Prevalence rate of elastofibroma dorsi was 1.2%, after reviewing 10,056 imaging records. Most patients (69%) were women (p<0.05). Mean age±SD was 62.7±2.3 (range: 28-72) with the highest frequency in the middle age (p<0.05). Majority of cases were unilateral (77.5%), commonly on the right side (95% of unilateral lesions). Eighty-eight percent of right- vs. 71% of left-handed individuals had the mass ipsilateral to their dominant side (p<0.05). About 2/3 of patients were asymptomatic. Mean±SD Hounsfield unit of the masses was 33±4.1 (range:19-48), while for the adjacent muscle, Hounsfield unit it was 46±3.7 (range:35-55). All taken biopsies confirmed the diagnosis of elastofibromadorsi.
Conclusion:Most cases were found unilaterally on the right side of middle-aged women.
Optimization of machining by the milling cutter
Authors: Usubamatov Ryspek , Bayalieva Cholpon , Kapayeva Sarken , Sartov Tashtanbay
Published: December 2022

The authors have requested that this preprint be removed from Research Square.
Modeling of solid-liquid coupling and material removal in robotic wet polishing
Authors: Pan Jie , Chen Fan , Meng Jin , Zhao Huan , Dong Zhaocheng , Pu Donglin , Ruan Peng
Published: December 2022

In this paper, the flow characteristics of the polishing fluid between the polishing pad and the workpiece are studied for the robotic wet polishing process, and the distribution of the polishing fluid radial velocity Ur and the liquid film thickness z at different rotating radii r are revealed. The two-dimensional computational domain consisting of the polishing pad surface, the workpiece wall and the polishing fluid is established. The particle-liquid two-phase flow simulation is carried out in Fluent, and the influence of different rotation rate ω of the polishing pad and different robot swing speeds v2 on the change and distribution of polishing fluid flow rate and temperature are elaborated. The position distribution of the abrasive particles in the wet polishing process and the velocity distribution of particles in the x and y directions impacting on the workpiece surface are simulated and analyzed for polishing fluids with different average abrasive diameters dp. The three-dimensional calculation domain for wet polishing is established; the workpiece surface erosion is simulated in Fluent; the material removal rate MRR and standard deviation of material removal σ on the workpiece surface are calculated considering different combinations of polishing fluid properties Ci and polishing kinematics Pi. Under the same process parameters, the material removal rate test value MRRT and the standard deviation of material removal test value σT are compared with the simulated values, respectively. The results show that under the combination of 64 groups of physical parameters C1-C64 of the polishing fluid, the error between the test value MRRT, σT and the simulation value MRR, σ is within 5%. With 64 sets of polishing kinematics parameters P1-P64, the average error between the test value MRRT and the simulated value MRR is 4.19%. However, when the polishing pad rotation rate ω is high, there is an inefficient polishing area in the smaller radius from the polishing pad rotation center, which results in a lower MRRT in some tests than that in simulation, with an maximum error of 8.1%. The average error between the test value σT and the simulation value σ is 3.77%. When the pressure P of the polishing pad is high, the large particles embedded in the polishing pad surface follow its rotation, causing deep scratches on the workpiece surface, which results in a larger σT in some tests, with an maximum error of 7.8%. In conclusion, the material removal principle and the influence of different process parameters in the robotic wet polishing process are revealed in this paper.through modeling and simulation of the particle-liquid two-phase flow, giving an accurate estimation of the material removal rate of the robotic wet polishing process.
Synchrotron Fourier transform infrared microspectroscopy (SFTIRM) analysis of beta amyloid aggregation/clearance in Al-induced Alzheimer’s’ disease in rat brain hippocampal tissue
Authors: Khalil Safaa K. H. , hotaby W. El , Ahmed Gehan , Sherif Hadeer H.A. , Kamel Gihan , Abbas Lamyaa
Published: December 2022

Aluminium (Al) can trigger protein misfolding, beta amyloid (Aβ) aggregation and induced Alzheimer’s disease (AD)-like in rat model. Lepedium sativum (LS) water extract proved promising curative effects and its ability to restore the protein integrity was reported in our previous reports. In this study, we utilized Synchrotron Fourier Transform Infrared Microspectroscopy (SFTIRM) and multivariate analysis to investigate and monitor more thoroughly the process of protein misfolding in response to Al and LS treatment in rat hippocampal brain tissue. The results revealed a marked increase in the protein β-structure in AD group after 42d over the random coil structure. Meanwhile, after 65d ~ 91% of the amide I is random coil and the rest is anti-parallel β-sheets, alpha helix structure is absent in both tested times. Incredibly, this random coil structure is totally absent in the curative group; instead it is dominated by a drastic increase in the protein β-structure suggesting the clearance of Aβ takes place through β-structure transit phase. The role of β –structure & random coil as a transit phase in transformation of Aβ and/or clearance in response to AL and LS treatment is supported by different calculated %area ratios measurements. SFTIRM gave unique and deeper cluster of data.
The feasibility of Negative Pressure Wound Therapy versus Standard Dressings in Paediatric Hand and Foot Burns Protocol: A Pilot, Single-Centre, Randomised Control Trial
Authors: Lumsden Emma , Kimble Roy , McMillan Catherine , Storey Kristen , Ware Robert , Griffin Bronwyn
Published: December 2022

Introduction: The goal of paediatric hand and foot burn management is hypertrophic scar and/or contracture prevention. The risk of scar formation may be minimised by integrating Negative Pressure Wound Therapy (NPWT) as an acute care adjunct as it decreases the time to re-epithelialisation. NPWT has known associated therapeutic burden; however, this burden is hypothesised to be outweighed by an increased likelihood of hypertrophic scar prevention. This study will assess the feasibility, acceptability and safety of NPWT in paediatric hand and foot burns with secondary outcomes of time to re-epithelialisation, pain, itch, cost and scar formation.
Methods and analysis: This is a single site, pilot randomised control trial. Participants must be aged ≤16-years, otherwise well and managed within 24hours of sustaining either a hand or foot burn. Thirty participants will be randomised to either standard care (Mepitel® – a silicone wound interface contact dressing – and ACTICOAT™ – a nanocrystalline silver-impregnated dressing) or standard care plus NPWT. Patients will be reviewed until three months post burn wound re-epithelialisation, with measurements taken at dressing changes to assess primary and secondary outcomes. Surveys, randomisation and data storage will be done via online platforms and physical data storage collated at the Centre for Children’s Health Research, Brisbane, Australia. Analysis will be performed using Stata statistical software.
Ethics and Dissemination: Queensland Health and Griffith University Human Research ethics approval including a site-specific assessment was obtained. The findings of this study will be disseminated through clinical meetings, conference presentations and peer reviewed journals.
Registration and Details: Registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12622000044729, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=381890&isReview=true, registered 17/01/2022).
Health inequality and its determinants: A cross-sectional study in Hubei, China
Authors: Lei Xiaosheng , Guan Cuiling , Yan Ni
Published: December 2022

The authors have requested that this preprint be removed from Research Square.
Double-layer SOC and SOH Equalization Scheme for LiFePO4 Battery Energy Storage System using MAS Blackboard System
Authors: Lu Zhongda , Wang Qilong , Xu Fengxia , Fan Mingqing , Peng Chuanshui , Yan Shiwei
Published: December 2022

26650 LiFePO4 battery, as an ideal energy storage battery, has the shortcomings of fast aging speed and large dispersion of aging trend. However, it is noted that the 26650 LiFePO4 battery with high aging trend dispersion shows the characteristics of grouping. Therefore, this paper proposes a SOC and SOH double-layer equalization scheme for such batteries based on a multiagent blackboard system(MABS) by utilizing such characteristics. On the basis of MABS, the battery units with similar SOH are clustered into a group by a hierarchical clustering algorithm. Then SOH balancing is performed by changing the depth of charge and discharge (DOD) between groups, and SOC balancing is performed within the group. MATLAB simulation results verify the effectiveness of the proposed scheme in ensuring the balance of battery charge and discharge and prolonging the life of the battery energy storage system(BESS).
Electrocapillary flow in Melcher – Taylor experimental setup
Authors: Gelfgat Alexander Yu. , Horstmann Gerrit Maik
Published: December 2022

Electrocapillary two-phase flow in a confined cavity is studied. The flow configuration corresponds to a classical experiment of Melcher and Taylor. It is shown that the computed streamlines of the flow of the heavier liquid (corn oil) qualitatively represents the corresponding experimental image. With the increase of electrocapillary forcing, the flow pattern changes, so that the main circulation localizes near boundary with a larger electric potential. It is shown that numerical results satisfy the Lippmann equation connecting electrically induced surface tension with non-uniform surface electric potential.
Molecular characterization of Feline coronavirus in Shandong from 2017 to 2019, China
Authors: Song Xiaoli , Zhang Chuanmei , Li Wenfeng , Shan Hu , Yang Haiyan
Published: December 2022

Feline coronavirus (FCoV) is the causative agent of feline infectious peritonitis and diarrhoea in kittens worldwide. In this study, a total of 73 feline diarrhoeal faecal samples were collected from veterinary hospitals in ShanDong province from 2017 to 2019. FCoV was detected in 58.23% (46/79) of the samples using the RT-nPCR method. The results showed that the detection rate of FCoV in healthy cats and sick cats were 41.7% (10/24) and 81.6% (40/49), respectively. Full gene amplification and sequencing of N, M and S2 of positive FCoV isolates were performed. There was an amino acid mutation site (M1058L) in the S gene, which could be predicted to be used as a marker for Feline enteric coronavirus (FECV) and Feline infectious peritonitis virus (FIPV). These results enriched the epidemiological information of FCoV and provided an important reference for the prevention of FCoV in Shandong.
RETRACTED: The role and significance of socio-historical phenomena in the development of personality (on the example of S. Kadyrbayev)
Authors: Çetin Nur , Oshangaliyev Kazhumkan , Aitmagambetov Duman , Sailaubai Yerlan , Saktaganova Elmira
Published: December 2022

The authors have requested that this preprint be removed from Research Square.
Bio-based poly(propylene 2,5-furandicarboxylate-co-propylene 2,5-thiophenedicarboxylate): synthesis and characterization
Authors: Wang Guoqiang , Dong Yakun
Published: December 2022

This study aimed to reduce the cost of poly(propylene 2,5-furandicarboxylate) (PPF) using cheap 2,5-thiophene dicarboxylic acid (TDCA) and determine the effect of TDCA on properties of PPF. 2,5-Furandicarboxylic acid (FDCA), TDCA and 1,3-propanediol (PDO) were melt polymerized to synthesize poly(propylene 2,5-furandicarboxylate) (PPF), poly(propylene 2,5-thiophenedicarboxylate) (PPTF), and poly(propylene 2,5-furandicarboxylate-co-propylene 2,5-thiophenedicarboxylate) (PPFTFs). FTIR and NMR spectra suggested that the copolymers were successful synthesized. The large carboxyl intercalation angle and low electronegativity of the thiophene ring result in weaker intermolecular interaction. Therefore, glass transition temperature decreased with increasing the content of TDCA. All copolyesters exhibit diffraction peaks similar to β-crystal of PPTF (more stable crystalline phase), indicating TDCA can promote the growth of β-crystal of PPTF. PPTF has a higher crystallinity than PPF due to the difference between furan rings and thiophene rings. In addition, the cheap TDCA-based polyesters in terms of costs seem to be a more worthwhile option.
Every Fq -linear code is equivalent to a non-trivial multi-twisted code
Authors: Samei Karim , Mahmoudi Saadoun
Published: December 2022

Aydina and Halilovi\'{c} [Finite fields Appl. 45 (2017) 96-106] introduced multi-twisted codes and studied some of their basic properties. Let S be a finite commutative Fq-algebra. An Fq-linear code over S of length n is an Fq-submodule of Sn. Recently, Mahmoudi et al. [Finite fields Appl. 64 (2020) 101665] studied Fq-linear codes over Fq-algebras. In this paper, we show that every Fq-linear code is equivalent to a multi-twisted (MT) code. This gives us a new point of view to study linear codes. In particular, we can investigate the structure of multi-twisted codes instead of Fq-linear codes.
2000 Mathematics subject classification: 94B15, 16S36.
Novel Application of Real-Time Editable 3D-reconstructed Imaging in a Mixed-Reality Holographic Overlay Using a Video Pass-through Head-Mounted Display – A Pathway to future Navigation in Thoracic Surgery?
Authors: Arensmeyer Jan , Bedetti Benedetta , Schnorr Philipp , Buermann Jens , Zalepugas Donatas , Schmidt Joachim , Feodorovici Philipp
Published: December 2022

Introduction: 3D reconstructions of widely available high-resolution imaging is only rarely used for preprocedural assessment in thoracic surgery. However, it is a promising tool that aims to improve patient-specific treatment planning. Increasingly available mixed reality hardware based on video pass-through technology enables to project image data as a hologram onto the patient. We describe the novel method of real-time 3D surgical planning in a mixed reality setting presenting two representative cases.
Material and Methods: A mixed reality system was set-up using a high-performance workstation running a video pass-through based head-mounted display. Image data of computer tomography was imported and visually customized through live editing. The image-based hologram was projected onto the patient highlighting the regions of interest. Results: Two oncological cases were selected, both presenting large tumor masses in the thoracic cavity. We aligned 3D holographic image data onto the patient allowing us to investigate the relationship between anatomical structures and their respective body position.
Discussion and Outlook: The exploration of holographic overlay proved to be promising in improving preprocedural surgical planning, particularly on complex oncological tasks in the thoracic surgery area. A pilot study on approach planning shall therefore be conducted. Ongoing technological progresses of extended reality hardware and intelligent software features will most likely enhance applicability and range of use in surgical fields within the near future.
Identification of a novel GOPC-RET fusion in a patient with lung adenocarcinoma: A case report
Authors: Zhuo Hongyu , Meng Nan , Cao Lei , Wang Dongliang , Niu Beifang , Ren Li
Published: December 2022

Background: RET fusion has reported in 1–2% of lung adenocarcinomas, and it is one of the key driver mutations and an actionable target. Non-small cell lung cancer (NSCLC) patients harboring RET fusion can obtained clinical benefit from the therapy with multi-kinase inhibitors like cabozantinib and potent and highly selective RET inhibitors like selpercatinib (LOXO-292) and pralsetinib (BLU-667). In NSCLC, several partners of RET have been reported. However, to the best of our knowledge, no report is available on the golgi-associated PDZ and coiled-coil motif containing gene (GOPC) as a partner of RET fusion in NSCLC.
Case presentation: Here, we identified a novel GOPC-RET fusion in a 63-year-old female patient with lung adenocarcinoma by next-generation sequencing (NGS). The GOPC-RET fusion is composed of exon 1–4 of GOPC and exon 12–20 of RET that retains the intact RET kinase domain.
Conclusions: To the best of our knowledge, this represents the first report of GOPC-RET fusion in a patient with lung adenocarcinoma. The novel GOPC-RET fusion has immediate clinical implications for patients with malignancy.
Manipulating micro-electric field and coordination-saturated site configuration boosted activity and safety of frustrated single−atom Cu/O Lewis pair for acetylene hydrochlorination
Authors: Huang Chaofeng , Peng Junchen , Dong Dandan , Wang Zongyuan , Yang Hong , Qiao Dongyang , Wang Qinqin , Sun Wei , Liu Minmin , Wang Jiajun , Mingyuan Zhu , Dai Bin , He Fei
Published: December 2022

Simultaneously boosting acetylene hydrochlorination activity and avoiding formation of explosive copper acetylide over Cu-based catalyst, which represented a promising alternative to Hg-based and noble metal catalysts, remained challenging. Herein, we fabricated a frustrated single−atom Cu/O Lewis pair catalyst (Cu/O−FLP) by coupling epoxide group (C−O−C) with atom-dispersed Cu−cis−N2C2Cl center to address this challenge. The basic epoxy site modulated the electron-deficient state of Lewis-acidic Cu center and paired with the Cu−cis−N2C2Cl moiety to preferentially break HCl into different electronegative Cu−Clδ− and C−O−Hδ+ intermediates, which further induced both an extra localized electric field to polarize acetylene and a upshift of the d-band center of catalyst, thereby promoting adsorption and enrichment of acetylene by enhancing the dipolar interaction between acetylene and active intermediates. Moreover, the generated Cu−Clδ− and C−O−Hδ+ drastically reduced the energy barrier of rate-limiting step and made vinyl chloride easier to desorb from the Lewis-basic oxygen-atom site rather than traditional Lewis-acidic Cu center. These superiorities ensured a higher activity of Cu/O-FLP compared with its counterparts. Meanwhile, preferential dissociation of HCl endowed single-atom Cu with the coordination-saturated configuration, which impeded formation of explosive copper acetylide by avoiding the direct interaction between Cu and acetylene, ensuring the intrinsic safety during catalysis.
Effect of abdominal aortic calcification on the prognosis and recurrence of colorectal cancer stages II–III: A retrospective cohort study
Authors: Imaoka Kouki , Shimomura Manabu , Shimizu Wataru , Akabane Shintaro , Ohira Masahiro , Imaoka Yuki , Yoshinaka Hisaaki , Ono Kosuke , Mochizuki Tetsuya , Matsubara Keiso , Bekki Tomoaki , Hattori Minoru , Ohdan Hideki
Published: December 2022

Purpose: Abdominal aortic calcification (AAC) is a well-known risk marker for cardiovascular disease. However, its clinical effect on patients who underwent radical surgery for colorectal cancer (CRC) stages II–III is unclear. This study aimed to analyze the associations between AAC and prognosis of patients with stage II–III CRC.
Methods: To evaluate the effect of AAC on clinical outcomes, prognosis, and metastatic patterns of CRC, we analyzed 362 patients who underwent radical surgery for stage II–III CRC between 2010 and 2018.
Results: The high AAC group had significantly worse overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) after propensity score matching to adjust for differences in baseline characteristics of patients and tumors. In the multivariate Cox regression analyses, a high AAC was an independent risk factor for poor OS (hazard ratio [HR], 2.38; 95% confidence interval [CI], 1.23–4.59; p=0.01), poor CSS (HR, 5.22; 95% CI, 1.74–15.6; p<0.01), and poor RFS (HR, 1.83; 95% CI, 1.19–2.83; p<0.01). A high AAC was not associated with a risk of lung metastasis or local or peritoneal recurrence, but a risk for liver metastasis of CRC.
Conclusion: A high AAC showed a strong relationship with poor OS, CSS, and RFS after curative resection for stage II–III CRC. A high AAC was also associated with a risk for liver metastasis, which may worsen the prognosis in stage II–III CRC. ACC could be a new clinical tool for predicting the prognosis for patients in stage II–III CRC.
Mapping the invisible sacred center of Bulverket’s interior water square: alignment to Gotlands’ northern strait and vi, and to a “system” of early medieval stone church locations and related orientations; possible evidence of a subsequent intrusive landscape pattern focused on the adjacent Tingstäde church on land
Authors: Doxtater Dennis
Published: December 2022

This study of a cultural landscape at the cusp of the Norse – Christian transformation assumes a technical ability to accurately survey on land and ice. Beginning with probability tests of two existing vis (bisects) with vertexes at significant natural or prehistoric features to the North, these patterns are compared with the likelihood of identical geometry being created by random points in test areas. The Bulverket center and Tingstäde church on the shore of the lake create vi centered data points to map accurate three-point alignments involving two possible groups of churches. The alignments of the Bulverket focal point of the lake platform are separately tested against random phenomena producing a statistical proof that land and ice was being very accurately surveyed to align numerous churches. It follows that land surveyed azimuths to either of the center points at Tingstäde Trask (lake) and any points in their systems might create the varied orientations of these churches; they range from 14° north and 18° south of due East. At each church, pairs or triads of azimuths from other church lat/long points create squares or parallelograms whose diagonals mathematically are within one degree of church orientations measured from Swedish digital maps. This kind of geometric determination of structure orientation might have begun with the sacred Bulverket platform square itself.
Assessment Of Health Related Quality Of Life Of Children With Nephrotic Syndrome and Their Care Takers At A Tertiary Hospital In Addis Ababa, Ethiopia
Authors: Mulatu Abdi , Abebe Bezaye , Hawlet Michael , Mechal Desalegn , Nigusie Mulualeme
Published: December 2022

Background: Nephrotic syndrome (NS) is one of the commonest pediatric chronic renal problems affecting children’s worldwide. Beyond the well-known effects of on kidney function, NS can also have impact on the patients and care givers life style, peer relationship, social functioning, intellectual functions and behavioral characteristics.
Objective: To assess the quality of life of children with NS as well as their caregivers and to determine the factors that adversely affect it.
Methods: A cross-sectional analytical study conducted using a pre coded, pretested structured questionnaire including PedsQoLTM 4.0 scale score generic core and family impact module. Data obtained for demographic and clinical parameters of children and for each domain of generic core and family impact module and data was be analyzed using IBM SPSS® version 26.
Results: 153 children aged 4-18 years with NS were included over a period of three months. Among the scores with median (inter-quartile range) the domains of generic core scale, child school performance was most affected with 73(53.0-97.5) followed with child physical performance 87(75-97.5). Children whose parents were earning less (p=0.009), children having hypertension (p=0.047) and steroid resistant clinical type (p=0.016) of NS were at increased odds of encountering poorer child health related quality with AOR of 0.306, 2.464 and 2.560 respectively. In the family impact module domains with median (inter-quartile range), the most affected are being ‘worry’ with 60.0 (45.5-75), followed with emotion 77(54.5-90.0). It was demonstrated that caregivers of child with hypertension are at 4.3times(AOR,4.3, p=0.016)increased risk of having poorer quality of life(QoL) than those without.
Conclusion: School performance and ‘worry’ are the most affected domains in child generic scale and family impact modules respectively. Low socioeconomic status, Steroid resistant nephrotic syndrome and hypertension are also associated with poorer HRQoL.
New results on exponential stability analysis for non-switched and switched systems with interval time-varying delays
Authors: Li Xu , Zhao Kunyang , Yu Jiajia , Wang Hao , Chen Fangyu , Li Te
Published: December 2022

Nowadays the Krasovskii functional method is still widely used for stability analysis of many delay systems. It means that improving the resultful method is significative for obtaining new stability criteria. Thus, exponential stability analysis for non-switched and switched systems with interval time-varying delays is restudied in this paper. A generalization of the Krasovskii functional method for nonlinear delay systems is proposed. This is achieved by weakening a condition in the Krasovskii functional method. It is proved that the generalized method can be extended to study switched nonlinear systems with delays. How to apply the new method to obtain stability criteria for non-switched and switched linear systems with interval time-varying delays is also shown and three examples are given to illustrate that the conditions of the linear systems are less conservative than some existing criteria.
Plasmonic characteristics of rhodium dual broken nanorings in UV-visible regime
Authors: Zhang Yue , Xiong Tao , Dong Dandan , Wang Wei , Sun Cheng
Published: December 2022

This work reports on the plasmonic properties of a symmetry-breaking system consisting of rhodium dual broken nanorings, in the ultraviolet-visible regime. In the structure, two rhodium broken rings are located with a separation on the scale of nanometers. As the separation, the light polarization, and the relative orientation of the broken angles are respectively varied, the plasmonic scattering efficiency of the system is investigated, using the finite difference time domain method. Multiple plasmonic resonances are revealed, and the associated asymmetry-induced Fano-like lineshapes are fitted to a model that employs multiple Fano lineshape functions. The resonance wavelengths, the spectral widths, and the characteristic q values are determined from the best fit parameters, and the plasmonic characteristics of the system are quantitatively probed. The results in this work may be beneficial in designs of plasmonic devices that operates at ultraviolet-visible wavelengths.
Satzlänge: Definitionen, Häufigkeiten, Modelle (Am Beispiel slowenischer Prosatexte)
Authors: Kelih Emmerich , Grzybek Peter
Published: December 2022

Die vorliegende Untersuchung versteht sich als ein Beitrag zur Satzlängenforschung. Nach einleitender Darstellung der Analysemöglichkeiten auf der Ebene der Satzlängen, geht es hauptsächlich um die Diskussion der Anwendung von unterschiedlichen Satzdefinitionen. Auf der Basis eines Korpus slowenischer Texte wird der Frage nachgegangen,welchen Einfluss die Anwendung unterschiedlicher (durchaus üblicher) Satzdefinitionenauf (a) deskriptive Kenngrößen der Häufigkeitsverteilung hat, und (b) inwiefern davondie Adäquatheit und Güte theoretischer Verteilungsmodelle abhängt.
Optimizing the Training of Models for Automated Post-Correction of Arbitrary OCR-ed Historical Texts
Authors: Englmeier Tobias , Fink Florian , Springmann Uwe , Schulz Klaus U.
Published: December 2022

Systems for post-correction of OCR-results for historical texts are based on statistical correction models obtained by supervised learning. For training, suitable collections of ground truth materials are needed. In this paper we investigate the dependency of the power of automated OCR post-correction on the form of ground truth data and other training settings used for the computation of a post-correction model. The post-correction system A-PoCoTo considered here is based on a profiler service that computes a statistical profile for an OCR-ed input text. We also look in detail at the influence of the profiler resources and other settings selected for training and evaluation. As a practical result of several fine-tuning steps, a general post-correction model is achieved where experiments for a large and heterogeneous collection of OCR-ed historical texts show a consistent improvement of base OCR accuracy. The results presented are meant to provide insights for libraries that want to apply OCR post-correction to a larger spectrum of distinct OCR-ed historical printings and ask for "representative" results.
Methodology and software for atmospheric correction of images obtained with unmanned aircraft to allow the safe location of vegetation
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kataev M. Yu. , Kartashov E. Yu. ,   Seversk Technological Institute, National Research Nuclear University «MEPhI», Smirnov D. S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

Unmanned aerial vehicles (UAV) provide a way to obtain images with high spatial resolution with relatively simple control of the vehicle and economic efficiency. Over the past 10 years, UAV measurement technology has changed significantly and has become popular due to its versatility and ease of use in commercial and scientific research. It should be noted that the methods of processing one-time received images allow solving various scientific and practical problems, however, during monitoring, when the dynamics of the state of objects (surface types) of the same territory is studied, the methodology and software remain questionable. One of the problems that hinder the study, for example, the dynamics of the state of objects on an agricultural field, is the radiometric accuracy of the obtained UAV images. In practice, the radiometric accuracy of measurements allows considering various lighting conditions at different periods of the day and year, by relevant types of digital sensors (digital cameras) used. The study is aimed at enabling a better flexibility when studying the dynamics of the state of objects located on the same territory at different times by taking into account the radiometric errors of UAV images when mapping the state of vegetation. The research methodology uses the real images of the UAV obtained from June to August 2019 for an agricultural field with winter wheat.
The problem of managing the learning behavior of insufficiently motivated students at the stage of mastering research competencies
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Buymov A. G.
Published: December 2022

Mastering the educational program within the framework of the «subject study – testing and exams» strategy is not a problem for the bigger part of students. Another thing is their further development, when the share of independent individual work and the search for creative solutions increases at the stage where they are supposed to acquire research competencies. This is a complex process, and not all students have enough motivation to successfully complete it. The article discusses the ideas of stimulating such students to study.
Comparison of time responses of an asymmetric modal filter obtained in different ways
Authors:   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Kenzhegulova Z. M. , Surovtsev R. S. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR), Khazhibekov R. R. ,   LLC «Russian Electrotechnical Society», group of companies «NPK Morsvyazavtomatika»
Published: December 2022

The results of comparing the time responses at the end of the asymmetric MF obtained by different approaches are presented. For this purpose, time responses were obtained by analytical, quasi-static and electrodynamic approaches, as well as by measurements. When compared with the results of the quasistatic approach, almost complete coincidence of responses was revealed (within 2%). The maximum deviation when compared with the results of the electrodynamic approach was 8% in amplitude and 29% in the delay of the decomposition pulses. A comparison of the results obtained analytically and using measurements of the MF layout revealed deviations in amplitude of 21% for the first and 8.7% for the second pulses, respectively, and 2.2 and 3.9% for their delays.
Investigation of the stability of an automatic system for regulating the flow rate of reflux in a stabilization column in the process of catalytic reforming
Authors:   Astrakhan State Technical University, Dzhambekov A. M. , Dmitrievsky B. S. ,   Institute of Automation and Information Technologies, Tambov State Technical University, Terekhova A. A. ,   Institute of Automation and Information Technologies, Tambov State Technical University
Published: December 2022

It is proposed to take into account the influence of uncontrolled disturbances on the regulation of irrigation flow into the stabilization column of the catalytic reforming unit catalyst stabilization unit by changing the coefficients of the polynomial of the denominator of the transfer function of the automatic irrigation flow control system based on a probabilistic approach to robust stability. To study the robust stability of the automatic irrigation flow control system in the stabilization column, a typical scheme of the regulation system is considered. To describe the problem, a general view of the denominator polynomial of the transfer function of an automatic irrigation flow control system in a stabilization column is obtained. For the robust stability of the automatic irrigation flow control system in the stabilization column under the influence of disturbances, the task of estimating the probability of stability of the family of polynomials of the denominator of the transfer function of the automatic control system is set. A family of polynomials of the denominator of the transfer function of an automatic irrigation flow control system in a stabilization column with uncertainty parameters varying in a cube is considered. The problem of estimating the probability of stability of a family of polynomials of the denominator of the transfer function of an automatic irrigation flow control system in a stabilization column is reduced to solving problems: sample generation and probability estimation by frequency. To assess the probability of stability of the family of polynomials of the denominator of the transfer function of the automatic irrigation flow control system in the stabilization column, four polynomials, including the nominal one, are given. Based on generating a sample of one hundred independent random variables, calculating the corresponding polynomials and checking their stability, the considered family of polynomials of the denominator of the transfer function of the automatic irrigation flow control system in the stabilization column has stability with a probability close to unity.
Eliminating the measurement ambiguity in phase direction finders with two orthogonal linear aerial arrays
Authors:   OJSC «NIIAP», Novosibirsk, Porubov G. G. , Denisov V. P. ,   Tomsk State University of Control Systems and Radioelectronics (TUSUR)
Published: December 2022

The algorithm of estimating the bearing in phase direction finders with a flat aerial array is suggested according to a set of differences in signal phases measured between the elements of the aerial system. The aerial system presents two linear lattices located orthogonally. The law of distributing the error probabilities of the phase measurements does not influence the algorithm. The algorithm can be applied for the direction finders equipped with the orthogonal linear lattices having any number of phase-measuring bases.
Analysis of shunt converter transistor switch current depend at the output voltage value and solar array characteristics
Authors:   JSK Academician M.F. Reshetnev Information Satellite System, Dudarkov D. O. , Khlystunov M. E. ,   JSK Academician M.F. Reshetnev Information Satellite System, Zhuravlyov I. M. ,   JSK Academician M.F. Reshetnev Information Satellite System
Published: December 2022

The article investigates shunt converter transistor switch current correlation from the output stabilized voltage level and solar array characteristics, including parasitic output capacitance. Shunt converter heat dependence graphs at output voltage for various solar array parasitic characteristics are obtained. Calculation results verification by shunt converter prototype sample was obtained.
Pharmacokinetics, drug-likeness, antibacterial and antioxidant activity of secondary metabolites from the roots extracts of Crinum abyssinicum and Calotropis procera and in silico molecular docking study
Authors: TEGEGN Getachew , MELAKU Yadessa , ESWARAMOORTHY Rajalakshmanan , ENDALE ANNİSA Milkyas
Published: December 2022

Crinum abyssinicum and Calotropis procera were traditionally used for the treatment of different diseases such as hypertension, diabetes, hepatitis B, skin infection, anticancer, asthma, fever, and diarrhea. The structures of the compounds were characterized by 1H NMR, 13C NMR, and DEPT-135 spectra. Compounds 1-3 were reported herein for the first time from the species of C. abyssinicum. The DCM/MeOH (1:1) and MeOH roots extracts of C. abyssinicum showed significant inhibitory activity against S. aureus and P. aeruginosa with a mean inhibition zone of 16.67 ± 1.20 and 16.33 ± 0.33 mm, respectively. Compounds 4 and 5 showed promising activity against E. coli with a mean inhibition zone of 17.7  0.8 and 17.7  1.2 mm, respectively. The results of DPPH activity showed the DCM: MeOH (1:1) and MeOH roots extracts of C. abyssinicum inhibited the DPPH radical by 52.86  0.24 % and 45.6  0.11 %, respectively, whereas compound 5 displayed 85.7 % of inhibition. The drug-likeness analysis showed that compounds 2-4 satisfy Lipinski’s rule of five with zero violations. Compounds 2, and 6 showed binding affinities of −6.0, and −6.7 kcal/mol against E. coli DNA gyrase B, respectively, while 3 and 5 showed −5.0 and −5.0 kcal/mol, respectively against human peroxiredoxin 5. Therefore, the in vitro antibacterial, radical scavenging activity along with the molecular docking analysis suggest the potential use of the extracts of C. abyssinicum and compounds 2, 5, 6, and 3, 5 can be considered as promising antibacterial agents and free radical scavengers, respectively.
What causes social media users to engage and mimic virtual influencers? The role of self-congruity
Authors: Suprawan Lokweetpun , Pojanavatee Sasipa
Published: December 2022

Influencer marketing has been widely utilized in marketing communication. With the growing interest in virtual influencers, this study aims to investigate why social media users would interact with virtual influencers. The research model was developed based on the self-congruity theory. The data were obtained by questionnaires distributed to social media users using judgmental sampling (respondents were above 18 years old and actively used Instagram within the past six months). The questionnaire was posted on social media, and 230 responses were collected and analyzed using a covariance-based structural equation. Influencer-brand fit was found to have a weak direct effect on engagement (γ = 0.158, p < 0.05), but insignificant direct effect on mimicry desire (γ = 0.160, p > 0.05). Value homophily significantly affects both engagement and mimicry desire directly (β = 0.338 and β = 0.622, p < 0.01). Moreover, value homophily was found to fully mediate the virtual influencer-brand fit/mimicry desire relationship (B = 0.546, p < 0.01) and partially mediate the relationship of virtual influencer-brand fit/engagement (B = 0.229, p < 0.01). However, the mediating effect of mimicry desire on the virtual influencer-brand fit/engagement relationship was found to be non-significant (B = 0.065, p > 0.05). This study contributes to influencer marketing by highlighting value homophily as the most significant factor explaining why consumers respond to a virtual influencer when used as a message source in marketing communication.