bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnetohydrodynamic Simulations for Solar Active Regions using Time-series Data of Surface Plasma Flow and Electric Field Inferred from Helioseismic Magnetic Imager Vector Magnetic Field Measurements
Authors: Hayashi Keiji , Feng Xueshang , Xiong Ming , Jiang Chaowei
Published: January 2019

Temporal evolution of magnetic structures of the solar active region (AR) NOAA AR 11158, is simulated with our magnetohydrodynamic (MHD) simulation models using time-dependent solar-surface electric field or plasma flow data. Using the Solar Dynamics Observatory/Helioseismic Magnetic Imager vector magnetogram data, the solar-surface boundary electric field maps are derived with our recently developed algorithm to reproduce the temporal evolution of solar-surface vector magnetic field as observed. The plasma motion velocity maps are calculated through the Differential Affine Velocity Estimator for Vector Magnetograms. In both data-driven models, the simulated evolutionary magnetic field structures at strong-field low-beta regions appear near force-free state, as the current helicity density (

) are roughly constant along each field line. Although the magnetic energy simulated with the newly developed plasma-velocity-driven model is about 10% of that by the electric-field driven model, the plasma-velocity-driven model can maintain the frozen-in condition, and evolution of current and free energy generated by the solar-surface plasma motions can be spatially and temporally traced. The present MHD simulation models for AR system can be a step toward better, more realistic data-driven evolutionary modeling, in particular, establishing boundary treatments for introducing the time-dependent observation data in a physically and mathematically consistent manner.
Successful Treatment of Facial Atrophic Acne Scars by Fractional Radiofrequency Microneedle in Vietnamese Patients
Authors: Thi Kim Cuc Nguyen , Thi Lan Pham , Nguyen Van Thuong , Thi Minh Phuong Pham , Vu Nguyet Minh , Le Thi Mai , Dinh Huu Nghi , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Vojvodic Aleksandra , Tirant Michael , Lotti Torello
Published: January 2019

AIM: The aim of this study was to evaluate the effect of the fractional Radiofrequency microneedle treatment for facial atrophic acne scars.
METHODS: A group of 52 patients were recruited for the study. Goodman & Baronâ€™s acne scar grading system was used for assessment at their first visit and at the end of 3 months after the last treatment session.
RESULTS: The results displayed that 73.1% of patients have the improvement of the Goodman scar level after four times treatment. The Goodman and Baron scar point mean was reduced from 16 Â± 7.6 to 5.6 Â± 5.0 (p < 0.01). Post-inï¬‚ammatory hyperpigmentation was experienced in 5 patients (9.6%).
CONCLUSION: The microneedle fractional Radiofrequency is an effective treatment method of facial atrophic acne scars, with minor side effects and a short down-time.
Efficacy and Safety of Methotrexate in Combination with Mini Pulse Doses of Methylprednisolone in Severe Alopecia Areata. The Vietnamese Experience
Authors: Thi Van Anh Tran , Tran Lan Anh , Ha Anh Minh , Nguyen Van Thuong , Thi Minh Phuong Pham , Trinh Minh Trang , Dinh Huu Nghi , Vu Thanh Tung , Le Huyen My , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Treatment of severe alopecia areata remains very difficult, especially in alopecia areata totalis and alopecia areata universalis. Methotrexate is known to be effective in the treatment of severe and chronic autoimmune disorders.
OBJECTIVE: To assess the effectiveness and safety of MTX in combination with mini pulse dose of methylprednisolone in the treatment of severe alopecia areata.
PATIENTS AND METHODS: The open, uncontrolled study compared pre-treatment and after-treatment. Thirty-eight patients (age 16-64) with severity AA (SALT score > 50 %) visiting National hospital of Dermatology and Venereology from April-2004 to September-2015 were enrolled. All patients received oral methylprednisolone 24mg/day for 3 consecutive days of a week in combination with oral MTX 7,5 mg weekly. This regimen is maintained up to 12 weeks and follow-up until to 6 months.
RESULTS: After 6 months, 60.5% of patients show complete hair growth (good response) and 18.4% shows the medium response. There is a significant SALT score reduction: mean baseline SALT score 84.39 Â± 17.03 compared to mean post-treatment SALT score 24.19 Â± 29.42. Good clinical improvement noted in after 3 months. We do not observe any side- effects related to oral MTX and oral methylprednisolone, and no patients had to withdrawal treatment due to side- effects.
CONCLUSION: Combination Methotrexate and mini pulse dose of methylprednisolone are effective and safe in treatment severity alopecia areata.
Angioedema - Our Experience Focused On Socio-Demographic, Etiological and Clinical Characteristics of the Condition and Its Management
Authors: Dermendjiev Svetlan , Blagoeva Vesela Slavcheva
Published: January 2019

BACKGROUND: Angioedema (AE) is acute oedema of the skin and mucous surfaces, involving the respiratory and gastrointestinal tracts. AE could be a life-threatening medical condition. Regardless of its growing clinical importance, many aspects of its aetiology and pathogenesis remain poorly understood. Its incidence, demographic characteristics, diagnosis and therapy, need further investigation.
AIM: This study reports our experience with angioedema concerning its social and demographic characteristics, aetiology, clinical features, diagnosis and treatment outcomes. Study design: Eighty-eight patients with AE were enrolled. The study is a retrospective analysis of patients treated in our Clinics.
METHODS: All participants were asked on a voluntary basis to fill out a specially designed questionnaire on the day of their discharge. Other important data sources included: patientsâ€™ history and notes during the hospital stay, information from previous admissions, etc. Parametric and non-parametric statistical methods were used for data processing. Data analysis was performed using SPSS (SPSS Inc., IBM SPSS Statistica) version 20.0
RESULTS: Based on our results, AE affects more frequently patients over 50 years of age, regardless of their sex. Urban residents prevail, among them - more commonly working women. Non-steroidal anti-inflammatory drugs (NSAIDs), hormones and antibiotics were among the most common triggers â€“ in 8%, 4.5% and 11.4% of the cases respectively. In 9.09% of the patients, food-induced AE was seen, the most common foods reported, were â€“ nuts, eggs and egg products. The common sites of involvement were periorbital area and lips. In only 9.1% of the patients, oedema progressed to spread to the upper respiratory tract. Cardiac conditions were the most frequent underlying disorders â€“ 33%, of the patients, auto-immune thyroiditis was the second most common-14.8%, followed by musculo- skeletal disorders (10.2%) and diabetes (4.5%) Family history of allergy was seen in 8.4% of the patients, the most frequent allergic disorder, reported, was asthma. In patients with HAE, family history was present in 2.9% of the patients.
CONCLUSIONS: All patients received therapy with steroids and antihistamines, resulting in resolution of symptoms and no invasive procedures were necessary. Based on our results, the diagnosis of AE is often difficult and delayed and requires specialist evaluation. If recognised on time and adequately treated, the outcomes are favourable.
Using Patch Testing to Improve Therapeutic Outcome in the Treatment of Hand Eczema in Vietnamese Patients
Authors: Thi Minh Phuong Pham , Thi Minh Trang , Le Huu Doanh , Nguyen Van Thuong , Nguyen Huu Sau , Vu Thanh Tung , Le Thi Mai , Thi Ha Giang Quach , Dinh Huu Nghi , Cam Van Tran , Le Huyen My , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Hand eczema is a common chronic and relapsing skin disease with various clinical features. Hand eczema aetiology can be allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), atopic dermatitis (AD) and unknown or combination causes. If the causative agents are not detected treatment of hand eczema will be a failure. A patch test can be useful to detect causative agents in suspected allergic contact hand eczema. Then patients will avoid contacting them. This results in the improvement of hand eczema. In Vietnam, patch test has not been used before, so we conduct this study.
AIM: To identify causative allergens by using patch test with 28 standard allergens in consecutive patients.
METHODS: A group of 300 HE patients from the National Hospital of Dermatology and Venereology (NHDV) in Vietnam were enrolled in this study. They were divided into 4 groups-ACD, ICD, AD and unknown aetiology. The patient was patch tested with 28 standard allergens to identify the causative agents.
RESULTS: Among the 300 HE enrolled patients, ACD accounted for 72.7%, AD and ICD had the same rate of 12.7%. 39.3% of the patients had a positive patch test. Reaction to nickel sulfate was the most common (10.3%), followed by potassium dichromate (9.7%), cobalt (4%) and fragrance mix (3.1%). About one-third of the cases had relevant clinical reactions correlated with the contact agents and clinical history. Males reacted to cement, thiuram mix and formaldehyde more than females, while females reacted to a nickel more than males.
CONCLUSIONS: Hand eczema has variable clinical features and diverse aetiology. ACD is an important cause of hand eczema that can be managed with a patch test to detect causative allergens. Nearly 40% of HE cases had positive patch test. Relevant patch test reactions were seen in one-third of the patients. We propose using patch test detect causative agents in suspected allergic contact hand eczema. Then patients will avoid contacting them. This results in the improvement of hand eczema.
Anatomical Evaluation for Successful Dye Laser Treatment of Port Wine Stain in Vietnamese Patients
Authors: Pham Cao Kiem , Nguyen Quang Minh , Dinh Nguyen Quan , Quynh Hoa Phuong , Nguyen Hong Son , Van Thuong Nguyen , Nguyen Huu Sau , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: To assess the efficacy in the treatment of port wine stain in the head and neck by using (Vbeam perfectaÂ®).
METHODS: Forty-two port wine stain patients were recruited at the National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
RESULTS: We reported an excellent response (43.8%) (76%-100% lightening), a good response (18.8%) (51%-75% lightening), fair improvement (18.8%) (26%-50% lightening), and no response (18.8%) (0%-25% lightening).
CONCLUSION: In conclusion, pulsed dye laser is an excellent technique to remove port wine stains on the face and neck.
Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients
Authors: Van Thuong Nguyen , Duong Thi Lan , Nguyen Trong Hao , Chau Van Tro , Trinh Minh Trang , Thi Minh Phuong Pham , Dinh Huu Nghi , Cam Van Tran , Le Huyen My , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: To evaluate the efficacy of oral isotretinoin used alone and in combination with desloratadine in the treatment of moderate acne vulgaris.
METHODS: A comparative clinical trial was undertaken to evaluate the efficacy of oral isotretinoin alone and in combination with desloratadine in the treatment of 62 moderate acne vulgaris patients. Patients were randomised into two groups with 31 patients in each group. Each studied group's patient took 20 mg isotretinoin and 5 mg desloratadine per day. In the control group, patients took only 20 mg isotretinoin per day. The treatment time was 16 weeks. The evaluation and follow-up were done at week 2, 4, 8, 12 and 16 of the treatment.
RESULTS: The studied group had a better curative rate than the control group (45.2% versus 22.6%). The average number of inflammatory lesions in the studied group was significantly lower than the control group (0.19 versus 0.94). The mean GAGS score of the studied group was significantly lower than the control group (3.71 versus 6.52). Acne outbreaks rate of the studied group was lower than the control group (in week 2: 22.6% versus 45.2% and in week 4: 16.1% versus 38.7%, respectively). The rate of itchy was lower in the studied group.
CONCLUSION: In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isotretinoin alone.
The Effectiveness of Narrow Band Uvb (Nb-Uvb) In the Treatment of Pityriasis Lichenoides Chronica (PLC) In Vietnam
Authors: Le Huu Doanh , Ngo Minh Thao , Van Thuong Nguyen , Thi Minh Phuong Pham , Dinh Huu Nghi , Cam Van Tran , Le Huyen My , Vu Nguyet Minh , Le Thi Mai , Thi Thu Hien Do , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: This prospective clinical study presents the experiences with NB-UVB monotherapy in the treatment of PLC on Vietnamese patients.
METHODS: We enrolled at National Hospital of Dermatology and Venereology (NHDV), Vietnam, 29 PLC patients with generalised disease involving at least 60% of the total body surface (based on Nineâ€™s Rule) and/or failed to respond to other modalities of treatment. Patients were treated with NB-UVB followed the guideline of the psoriatic treatment of AAD-2010, three times weekly.
RESULTS: A complete response (CR) was seen in 24 out of 29 PLC patients (82.8%) with a mean cumulative dose of 9760.5 mJ/cm2 after a mean treatment period of 4.6 weeks (13.8 Â± 7.4 exposures). Mild side effects were observed: 69% erythema minimum, 55.2% irritation related to dry skin. No severe side effects were seen during the study. No relapses occurred in 24 CR patients within a mean period of 3 months after the last treatment.
CONCLUSION: NB-UVB therapy is an effective and safe option for the treatment and management of PLC.
Efficacy of Narrow - Band UVB Phototherapy versus PUVA Chemophototherapy for Psoriasis in Vietnamese Patients
Authors: Van Thuong Nguyen , Hoang Van Tam , Thi Minh Phuong Pham , Nguyen Trong Hao , Chau Van Tro , Dinh Huu Nghi , Pham Thi Thao , Thi Thu Hien Do , Cam Van Tran , Le Huyen My , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Psoralen UVA (PUVA) and narrow-band UVB (NBUVB) chemophototherapy are treatment options for psoriasis.
AIM: To compare the effectiveness of NBUVB with PUVA in Vietnamese psoriasis patients.
METHODS: We conducted a non-randomized trial on 60 patients with plaque-type psoriasis (30 NBUVB, 30 PUVA). Both regimens were thrice-weekly. The extent of lesion was assessed by the Psoriasis Area Severity Index (PASI). Clearance was defined as a â‰¥ 75% reduction in a follow-up PASI score from baseline. Patients with clearance were followed-up until 6 months after stopping treatment. Relapse was defined as 50% or more of the original extent.
RESULTS: The proportion of patients achieving PASI75 was comparable (76.7% in NBUVB versus 80% in PUVA; p > 0.05). Patients in both groups had a similar number of sessions to achieve clearance but patients in the PUVA group exposed to a significantly higher cumulative UV dose. After six months, the relapse rate was higher in the NBUVB group compared with in the PUVA group (p > 0.05).
CONCLUSION: Thrice weekly NBUVB is as effective as thrice weekly PUVA in treating psoriasis for Vietnamese patients.
Serial Excision for the Treatment of Giant Congenital Melanocytic Nevus: The Vietnamese Way
Authors: Nguyen Hong Son , Dinh Huu Nghi , Nguyen Duy Nham , Than Trong Tuy , Nguyen Bac Hung , Nguyen Van Thuong , Tran Thiet Son , Gandolfi Marco , Feliciani Claudio , Satolli Francesca , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: To investigate the efficacy of plastic surgery in the treatment of giant congenital melanocytic nevus (GCMN).
METHODS:  We enrolled 20 patients with 44 lesions and performed one of the following procedures: serial excision, skin grafting, tissue expansion, primary skin closure, distant flap, and adjacent flap. We assessed the outcome at 10 days and 6 months after surgery.
RESULTS: Of 44 surgical sites, the most commonly used reconstruction surgeries were serial excision (16), skin grafting (16), and tissue expansion (6). Other types were rarely used. All patients with serial excision had good outcome. A total of 81% and 19% of the patients with skin grafting had good and fair outcome, respectively. Around 83% and 17% of the patients with tissue expansion had good and fair outcome. No cases had bad outcome.
CONCLUSION: In conclusion plastic surgery is effective in the treatment of GCMN. There are different techniques but serial excision, skin grafts, and tissue expansion are most commonly used.
The Efficacy and Safety of Hyaluronic Acid Microinjection for Skin Rejuvenation in Vietnam
Authors: Nguyen Trong Hao , Vu Thi Phuong Thao , Van Nguyen Thuong , Vu Thai Ha , Dinh Huu Nghi , Vu Nguyet Minh , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Aging is an increasing concern of modern society, particularly facial ageing. In recent years, the microinjection technique has increasingly been emphasised as a skin rejuvenation strategy. Hyaluronic acid (HA) plays an important role in the hydration of the extracellular space and can thus improve skin hydration, firmness and viscoelastic properties.
AIM: To evaluate the efficacy and safety of HA microinjection in skin rejuvenation.
METHODS: We enrolled thirty participants underwent three sessions of HA microinjection involving multiple injections in the face or back of the hands at 2-week intervals. The aesthetic outcomes were assessed at baseline and after 2, 4 and 8 weeks. Clinical evaluation was based on the Global Aesthetic Improvement Scale (GAIS) and the Wrinkle Severity Rating Scale (WSRS).
RESULTS: Evaluation of photographs from 2, 4 and 8 weeks revealed significant clinical improvement in the brightness, texture and wrinkling of the skin. Analysis of the GAIS and WSRS scores revealed statistically significant results after 2 months.
CONCLUSION: Most of the participants felt satisfied with the treatment (93.3%).
Superantigens of Staphylococcus Aureus Colonization in Atopic Dermatitis and Treatment Efficacy of Oral Cefuroxim in Vietnamese Patients
Authors: Van Tro Chau , Nguyen Tat Thang , Tran Lan Anh , Nguyen Van Thuong , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Atopic dermatitis (AD) is a common, chronic, relapsing, genetically determined inflammatory skin disorder. Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of AD. Atopic skin is susceptible to infection with S. aureus.
AIM: This study was aimed to compare the skin S. aureus colonisation status and its secretion of superantigens in adult AD and healthy subjects and to evaluate the efficacy of two treatment regimens (oral cefuroxime plus topical betamethasone dipropionate 0.05% versus topical betamethasone dipropionate 0.05%) in AD patients.
METHODS: A group of 128 AD and 40 healthy subjects were recruited in this study and treatment efficacy was assessed by the SCORAD score.
RESULTS: S. aureus was found in skin lesions in 83.8% of AD patients while only 37.5% of healthy subjects possessed this kind of bacteria in the external nares (p < 0.001). Superantigen production was more common in S. aureus strains isolated from AD than the control group (58.6% versus 6.6%, p = 0.0006) and staphylococcal enterotoxin B was predominant (88.89%). 68 AD patients who had positive cultures with S. aureus were included in a clinical therapeutic trial. The isolated bacteria were all sensitive to cefuroxime. Patients were randomised to receive either oral cefuroxime 500 mg b.i.d. Plus topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 1, 36 patients) or only topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 2, 32 patients). The mean SCORAD scores of group 1 at baseline and after 1 and 2 weeks of treatment were 44.61, 26.69 and 16.61, respectively. The corresponding values for group 2 were 43.03, 32.53 and 23.41, respectively.
CONCLUSION: The reduction in SCORAD scores was significantly higher in group 1 than group 2 in comparison to the baseline value of each study group (p = 0.003 after 1 week and p < 0.001 at the end of treatment).
Effectiveness, Safety and Tolerance of Methotrexate in Vietnamese Psoriatic Arthritis Patients
Authors: Bui Thi Van , Ngo Minh Vinh , Tran Ngoc Anh , Tran Dang Quyet , Le Ngoc Diep , Dang Van Em , Nguyen Van Thuong , Thi Minh Phuong Pham , Thi Thu Hien Do , Dinh Huu Nghi , Le Huyen My , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: To access the effectiveness, safety and tolerance of methotrexate (MTX) in psoriatic arthritis (PsA) treatment.
METHODS:  We recruit 37 patients, admitted at HCMC Hospital of Dermato-Venereology from 1/2016 to 3/2017, with MTX dosage ranging from 10 mg to 15 mg per week.
RESULTS: Skin lesion response after 12 weeks improved PASI 50: 40.5%, PASI 75: 24.3%. Disease activity score decreased after 12 weeks with ∆DAS28 = -1.43 + 0.79, 37.8% PsA achieved complete remission. Nausea and vomiting were 8.1%. These symptoms were mild and transient. We did not stop MTX usage. The rate of elevating SGPT 2-3 times as much as the upper limit of the normal range was 2.7%.
CONCLUSION: We finally demonstrated that the rate of treatment response in Vietnam is the same as demonstrated by foreign authors in other countries.
Successful Psoriasis Treatment Using NB-UVB with Methotrexate: The Vietnamese Experience
Authors: Dang Van Em , Pham Diem Thuy , Bui Thi Van , Thi Xuan Tam Huynh , Ly Tuan Khai , Quynh Trang Nguyen , Vu Thu Trang , Nguyen Van Thuong , Nguyen Huu Sau , Thi Minh Phuong Pham , Dinh Huu Nghi , Hoang Van Tam , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018.
METHODS: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI).
RESULTS: The proportion of decreasing PASI was comparable (68.49% in NBUVB and MTX versus 57.62% in MTX alone); p < 0.05. Inside, good 28.58%, moderate 68.57% and poor 2.85% in NBUVB and MTX better than good 2.85%, moderate 71.4% and poor 25.72% in MTX alone; p < 0.05. The recurrence rate after 24 months of the NBUVB and MTX group (42.9%) was lower than the MTX alone group (71.4%); p < 0.05.
CONCLUSION: NBUVB and oral MTX have affected treatment with chronic plaque psoriasis better than oral MTX alone.
Quality of Life in Psoriasis Vietnamese Patients Treated with Metformin in Combination with Methotrexate
Authors: Thi Xuan Tam Huynh , Bui Thi Van , Tran Ngoc Anh , Dang Van Em , Tran Dang Quyet , Nguyen Van Thuong , Thi Minh Phuong Pham , Thi Lan Pham , Dinh Huu Nghi , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

A cross-sectional study was performed on 48 psoriasis Vietnamese patients treated with metformin as an add-on for methotrexate and 48 psoriasis patients treated methotrexate alone. The mean PASI scores were 5.25 Â± 5.72. Total QOL scores had a slight difference between patients treated metformin combined with methotrexate and methotrexate alone (62.32 Â± 18.1 vs 60.91 Â± 19.63). Combined therapy with metformin and methotrexate contributes to significantly improve the quality of life for patients with psoriasis.
A Promising Probiotic Irrigant: An In Vitro Study
Authors: El-sayed Hoda , Aly Yousra , Elgamily Hanaa , Nagy Mohamed M.
Published: January 2019

AIM: The present study aimed to investigate the inhibitory effect of Lactobacillus rhamnosus (B-445) as a probiotics irrigant on the growth of Enterococcus faecalis.
METHODS: Forty-two extracted single human canal anterior teeth were prepared with rotary instrumentation and sterilised. Teeth were divided into 3 groups according to the type of irrigant, N = 14. Three experimental groups were inoculated with E. faecalis and cultured for 21 days before use; Group 1 was 2.5% NaOCl (positive control), Group 2 was saline (negative control), Group 3 was the experimental probiotic irrigant. Paper point sampling of the canals of each group was obtained before irrigation (S1), immediately after irrigation (S2) and after 24 hours (post irrigation samples) (S3) to determine remaining colony forming units for E. faecalis. Also, Colony counts for L. rhamnosus in Group 3 after immediate irrigation, as well as 24 hours post irrigation, was performed to determine the survival profile of these bacteria in infected root canal with E. faecalis.
RESULTS: The NaOCl irrigant group had the lowest mean value of (log 10 CFU/mL) of E. faecalis after immediate irrigation and after 24 hrs post irrigation followed by the probiotic group, while the highest mean value was the saline group (P ≤ 0.001). The survival profile for L. rhamnosus in Group 3 after immediate irrigation and post-irrigation were slightly higher than for E. faecalis (P ≤ 0.001).
CONCLUSION: Lactobacillus rhamnosus which revealed a potential inhibitory effect on the growth of Enterococcus faecalis, could be used as a new natural, safe probiotic irrigant agent.
h of Enterococcus faecalis, could be used as a new natural, safe probiotic irrigant agent.
Efficacy Of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam
Authors: Nguyen Huu Sau , Nguyen Quang Minh , Nguyen Van Thuong , Pham Cao Kiem , Thi Thu Hiem Do , Thi Lan Pham , Cam Van Tran , Le Huyen My , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Molluscum contagiosum is a common viral disease primarily affecting children.
AIM: The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum.
METHODS: Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug.
RESULTS: The clearance of all lesions after 2, 4, 6, 8 weeks of treatment in both groups were 7.7%; 23.1%; 53.8%; 79.5% and 0%; 3.2%, 9.7% 22.6%, respectively (p < 0.05). Side effects were seen in both groups include burning (76.9% versus 19.4%; p < 0.05); redness (59% versus 14%; p < 0.01); desquamation (12.8% versus 19.3%; p < 0.05).
CONCLUSION: The efficacy of KOH solution in the treatment of MC was better than that of salicylic pomade and both products are safe, effective, and easy to apply at home.
Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor
Authors: Cam Van Tran , Nguyen Van Thuong , Tran Hau Khang , Le Huu Doanh , Thi Minh Phuong Pham , Nguyen Huu Sau , Nguyen Minh Thu , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Micheal , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor.
MATERIAL AND METHODS: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy.
RESULTS: After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III).
CONCLUSION: It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.
Successful Treatment of Intralesional Triamcilonon Acetonide Injection in Keloid Patients
Authors: Dinh Huu Nghi , Nguyen Huu Sau , Le Thi Xuan , Nguyen Van Thuong , Thi Minh Phuong Pham , Trinh Minh Trang , Hoang Van Tam , Cam Van Tran , Le Huyen My , Tran Hau Khang , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Micheal , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009.
METHODS: A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm2 of TCA. In the control group, TAC 32 patients were intralesionally injected 15 mg/1 cm2 of TCA. The result was evaluated basing on the criteria of Henderson (1998) and El-Tonsy (1996).
RESULTS: In comparison between 2 groups, good to excellent improvement in the studied group was statistically higher than the control group (90.7% versus 68.7%; p < 0.05). After each injection, the thickness of the scar was reduced 1.24 Â± 0.53 mm in the studied group and 0.81 Â± 0.39 mm in the control group. The disappearance of pain and itching after treatment were 86.6% and 95.5% in the studied group and 78.1% and 80% in the control group (p > 0.05). Ulceration, acne and troublesome with menstrual cycles were sometimes were noted more frequently in the control group than in the studied group.
CONCLUSION: Intralesional triamcinolone acetonide injection had a good result, and 7.5 mg/1 cm2 scar is the best dose for treatment of keloid.
Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam
Authors: Van Thanh Le Thai , Nguyen Minh Phuong , Tran Thi Thuy Phuong , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Micheal , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy.
AIM: The aim of our study was to evaluate the effect of the low-dose isotretinoin on the plasma homocysteine and serum folic acid level in the Vietnamese population.
METHODS: We conducted a longitudinal study to evaluate the effectiveness of the low-dose therapy on the plasma homocysteine and serum folic acid level of 52 acne patients after 6-8-week treatment at University Medical Center Ho Chi Minh City, Viet Nam. Patients had moderate-severe acne with the prolonged course, and most of them had a scar.
RESULTS: With a low dose of oral isotretinoin (0.37 Â± 0.11 mg/kg/day), after 6-8-week treatment, patients dropped the severity of disease, increased the plasma homocysteine level and decreased the serum folic acid level with significant differences in comparison to those before treatment. However, these changes do not exceed the normal range.
CONCLUSION: In overall, low dose isotretinoin treatment had effectiveness in decrease the severity of disease and no increasing the plasma homocysteine level as well as the serum folic acid level.
Successful Treatment of Vitiligo Vietnamese Patients with VitilinexÂ® Herbal Bio-Actives in Combination with Phototherapy
Authors: Trinh Minh Trang , Le Huu Doanh , Nguyen Van Thuong , Nguyen Huu Sau , Vu Thanh Tung , Dinh Huu Nghi , Cam Van Tran , Le Huyen My , Tran Hau Khang , Nguyen Trong Hao , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo.
AIM: This study aimed to investigate the efficacy and safety of VitilinexÂ® (herbal bio- actives) alone and in combination with UVB narrowband (311 nm) phototherapy, in the treatment of localised stable or active forms of vitiligo.
MATERIAL AND METHODS: Sixty two subjects with mean age 34.5 years (range: 18-58 years) with mild to moderate vitiligo, consisting of 36 females and 26 males were randomly divided into three treatment groups â€“ Group A (13 females, 10 males ) treated with VitilinexÂ® alone; Group B (12 females, 11 males) were treated with VitilinexÂ® in combination with narrowband UVB (311 nm) phototherapy for 15 seconds, using a handheld lamp and Group C (8 females, 8 males ) were treated with nbUVB (311 nm) phototherapy alone, for 15 seconds over a 12-week period.
RESULTS: In Group A, 9 patients (39%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 2 patients experiencing total repigmentation. 6 patients (26%) had marked improvement with a repigmentation rate between 50-75% while 5 patients (22%) showed a moderate response between 25-50% re-pigmentation rate. 3 patients (13%) had minimal or no improvement. In Group B, 16 patients (69.5%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 12 patients experiencing total re-pigmentation. 4 patients (17.5 %) achieved a marked improvement with a re-pigmentation rate between 50-75%; 2 patients (8.7%) showed a moderate response with a re-pigmentation rate between 25-50%. 1 (4.3%) patient had minimal or no improvement. In Group C, 6 patients (37.5%) achieved a re-pigmentation rate higher than 75%, with 2 patients experiencing total re-pigmentation. 4 patients (25%) achieved marked improvement with a re-pigmentation rate between 50-75% while 3 patients (18.75%) had a re-pigmentation rate between 25-50%. 3 patients (18.75%) had minimal or no improvement.
CONCLUSION: VitilinexÂ® herbal bio-actives in combination with nbUVB is a more effective treatment option for vitiligo with 87% of the patients achieving a re-pigmentation rate higher than 50%, compared to VitilinexÂ® alone (65%) or nbUVB alone (62.5%).
Microneedling Therapy for Atrophic Acne Scar: Effectiveness and Safety in Vietnamese Patients
Authors: Thi Minh Phuong Pham , Dang Bich Diep , Van Nguyen Thi Hai , Nguyen Van Thuong , Cam Van Tran , Khang Tran Hau , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

AIM: To evaluate the effectiveness and safety of micro-needling therapy in atrophic acne scar treatment.
METHOD: A prospective, single centred study was implemented in a total of 31 patients suffering from atrophic acne scar grade 2 to 4 of Goodman and Baron scaring grading system was recruited. They were treated by microneedle derma roller every week in 3 months. The scars were evaluated by a magic system camera and by dermatologists clinically using Goodman and Baron scaring grading system, and Lipper and Perez score at baseline, at final treatment, 1 month and 2 months after the final treatment.
RESULTS: The results showed improvement in all patients. The mean of Goodman and Barronâ€™s grade was decreased from 3.29 Â± 0.59 at baseline, 2.23 Â± 0.56 at final treatment, 1.93 Â± 0.58 one month after the completion of therapy and to 1.77 Â± 0.57 two months after the completion of therapy (with the p-value < 0.05). Similarly, Lipper and Perez score also dropped significantly from 36.48 Â± 12.07 at baseline to 23.16 Â± 15.01 at final treatment, to 17.83 Â± 7.00 one month after the final treatment and to 16.37 Â± 7.29 at two months after the final treatment (p-value < 0.05). Skin roughness and hyperpigmented spots got improved significantly. History of having nodular-cystic or vulgaris acne did not affect the effectiveness of the therapy. Side effects of the therapy were burning sensation, erythema but they were very mild and recovered in 1-2 days. No severe complication and post-inflammatory hyperpigmentation were noted. 83.3% of the patients satisfied after the completion of the therapy.
CONCLUSION: Skin needling is an effective and safe method for the treatment of atrophic acne scars.
Evaluation of Observational and Behavioural Pain Assessment Tools in Nonverbal Intubated Critically Adult Patients after Open - Heart Surgery: A Systematic Review
Authors: Barzanji Arvin , Zareiyan Armin , Nezamzadeh Maryam , Mazhari Marjan Seyed
Published: January 2019

BACKGROUND: Over 70% of patients hospitalised in an intensive care unit (ICU) often experience moderate to severe pain due to pre-existing diseases, trauma, surgery, aggressive procedures, and routine ICU care. Many patients hospitalised in ICU are not able to speak and express their pain due to various causes, including mechanical ventilation, reduced consciousness, and administration of sedative drugs. Therefore, the use of observational and behavioural pain tools is recommended in this group of patients given their inability to express pain.
AIM: To examine the existing observational and behavioural tools for assessment of in Nonverbal Intubated Critically Adult Patients after Open-Heart Surgery.
METHODS: A systematic review of available observational and behavioural tools for assessment of pain was undertaken using the COSMIN checklist. A literature search was conducted using the following databases: Ovid, Science Direct, Scopus, PubMed, and CINHAL databases, Google Scholar search engine as well as Persian resources Sid, Magiran, Iran doc, and IranMedex up to the end of 2017 were reviewed.
RESULTS: A total of 47 studies that had examined five tools used in intensive care units after cardiac surgery in patients under mechanical ventilation were reviewed. Each of the five tools included behavioural and observational items, and only one tool had physiological items. All the tools had been evaluated regarding validity and reliability. In the three tools, sensitivity, specificity, responsiveness, and satisfaction were considered.
CONCLUSION: Based on available evidence and investigations, CPOT and BPS tools have good validity and reliability to be used in pain assessment in Nonverbal Intubated Critically Adult Patients after Open-Heart Surgery. The NVPS tool requires more studies to be further confirmed before the assessment of pain in this group of patients.
The effectiveness of local surgical technique in treatment of axillary bromhidrosis
Authors: Van Thuong Nguyen , Manh Tan Nguyen , Thi Minh Phuong Pham , Minh Trang Trinh , Huu Nghi Dinh , Cao Kiem Pham , Huu Quang Nguyen , Cam Van Tran , Huyen My Le , Hau Khang Tran , Gandolfi Marco , Satolli Francesca , Feliciani Claudio , Tirant Michael , Vojvodic Aleksandra , Lotti Torello
Published: January 2019

BACKGROUND: Up to now, surgical excision of apocrine glands still has been a method that yields high treatment results and low rate of odour recurrent for patients, but many people worry about some serious complications that have been observed postoperatively, such as hematoma and skin necrosis. These prolong wound healing, leading to unsightly scars in the axillary fossae.
AIM: We conducted this research to investigate the effects and complications of our surgical technique for axillary bromhidrosis.
METHODS: Forty-three patients with axillary bromhidrosis were treated. An elliptical incision was made at a central portion of the area marked, with both tips of the ellipse along the axillary crease. The elliptical skin with the subcutaneous tissue was removed en lock. The adjacent skin was undermined to the periphery of the hair-bearing area with straight scissors. The undermined subcutaneous tissue was removed with curved scissors, and the skin was defatted to become a full-thickness skin flap. Any suspected hemorrhagic spots were immediately coagulated electrosurgically. Appropriate drains were placed, and the treated area was covered with thick gauze to each axilla. Arm movement was strictly controlled in the first 3 days post-operatively.
RESULTS: Thirty-one patients have been followed up and evaluated for 6 months. 56 out of 62 axillae (90.3%) showed good to excellent results for malodor elimination. All patients reported a reduction in axillary sweating. There were two axillae of skin necrosis and three axillae of hematoma, with one patient receiving an anticoagulant from a cardiologist after the first day of surgery, to treat heart valve disease. The Dermatology Life Quality Index (DLQI) score decreased significantly, and the quality of life improved after the operation.
CONCLUSION: Our technique is a simple surgical procedure and easy to perform helping to achieve results for high malodor elimination, with almost no serious complications. Patientâ€™s life quality improved significantly after the operation.
Spores of Bacillus coagulans GBI-30, 6086 show high germination, survival and enzyme activity in a dynamic, computer-controlled in vitro model of the gastrointestinal tract
Authors: Keller D. , Verbruggen S. , Cash H. , Farmer S. , Venema K.
Published: January 2019

The aim of this study was to assess the germination, survival and metabolic activity of the probiotic Bacillus coagulans GBI-30, 6086 [GanedenBC30] (BC30) in a dynamic, computer controlled in vitro model of the gastrointestinal (GI) tract, simulating human adults. Experiments were performed in the presence of a meal to maximise germination, due to the presence of germination-triggers. Both an upper GI tract (stomach and small intestine; TIM-1) and a colon model (TIM-2) were used, where material exiting TIM-1 was added to TIM-2. Spores of BC30 were introduced in the gastric compartment of TIM-1 and samples were taken immediately after the pylorus. Moreover, for 6 h, every hour the ileal efflux was collected and a subsample was plated for viable counts (spores and germinated cells). The remainder of the sample was fed to TIM-2, and after 24 h another sample was taken and tested for viable counts. In addition, samples were taken from the dialysates of the model and analysed using LC-MS/MS to determine bacterial metabolites and digestion products. Survival after transit through the gastric compartment was high (97%) and most cells were still in the spore form (76%). Survival after transit through TIM-1 was on average 51%, meaning that on average half of the orally provided spores was found back as cfu on the agar plates. Of these on average 93% were germinated cells and only 7% were spores. 24 h after the start of the experiments germination had increased in TIM-2 to 97% vegetative cells, and only 3% spores. No further loss of viability was observed in TIM-2. In terms of metabolic activity, increased levels of amino acids, dipeptides and citric acid cycle metabolites were found compared to experiments in the absence of BC30. In conclusion, BC30 spores germinate to a large extent (>90%) in the presence of germination triggers in the small intestine in a model that closely mimics the physiological conditions of human adults. Of the oral dose, as much as half of the cells survived transit through the upper GI tract, and based on the metabolite profile, these cells were metabolically active. Either these cells or the enzymes released from the dead cells aided in digestion of the meal. These insights help explain some of the observations in previous experiments, and support the understanding of the mechanism of action of the probiotic BC30.
Machine learning algorithms for the automated classification of contaminated maize at regulatory limits via infrared attenuated total reflection spectroscopy
Authors: Öner T. , Thiam P. , Kos G. , Krska R. , Schwenker F. , Mizaikoff B.
Published: January 2019

Mould infested maize poses a severe problem for farmers, food producers and for consumers worldwide. Mycotoxins are secondary metabolites produced by certain mould species that contaminate food and feed. The consumption of these toxins may cause serious health problems for humans and animals. The trichothecene deoxynivalenol (DON) constitutes one of the most commonly occurring Fusarium toxins encountered in maize and requires improved methods to limit its entrance into the food and feed system. While a variety of chromatographic and mass spectrometry methods for the identification of such toxins have been established, these are considered time-consuming, cost-intensive and require highly qualified personnel. Alternatively, optical techniques, such as mid-infrared spectroscopy offer rapid detection of fungal infections in cereals and other commodities with minimised sample preparation and analysis time. The present study demonstrates a rapid fungal contamination detection strategy in maize taking advantage of IR-spectroscopy combined with advanced machine learning algorithms. The developed method represents an advancement for the analysis of differences in protein and carbohydrate content revealed in the associated IR-spectra related to the amount of toxin contamination at the European Union (EU) regulatory limits for DON in maize (i.e. 1,250 μg/kg). The employed maize varieties are naturally infected samples or have been infected with Fusarium verticillioides, Fusarium graminearum or Fusarium culmorum. Sieved maize samples at the EU regulatory limit were correctly classified using machine learning approaches, therefore enabling the differentiation between DON-contaminated and non-contaminated maize samples. Specifically, a variety of machine learning methods, including Adaptive Boosting (AdaBoost), Random Forests, Support Vector Machine (SVM) and Multilayer Perceptron (MLP) demonstrated excellent classification and validation performance using the obtained IR-spectra. As a result, 183 maize samples of different varieties and infection levels were accurately classified. 94% of the non-contaminated samples and 91% of the contaminated samples were correctly classified using an MLP classification approach.