bluuebunny/crossref_metadata_2025 huggingface dataset:
BƯỚC ĐẦU ĐÁNH GIÁ TÌNH TRẠNG SỬ DỤNG HOÀNG KỲ TRÊN BỆNH NHÂN NỘI TRÚ TẠI BỆNH VIỆN Y HỌC CỔ TRUYỀN CẦN THƠ
Authors: Minh Hoàng Lê , Quang Vinh Lâm , Ngọc Chi Lan Nguyễn , Trần Nhất Phong Đào , Phượng Nhật Quỳnh Huỳnh , Ngọc Diễm Lê , Thị Thư Trần , Văn Thống Nguyễn
Published: April 2022

Mục tiêu nghiên cứu: Bước đầu đánh giá tình trạng sử dụng Hoàng kỳ trên bệnh nhân điều trị nội trú tại Bệnh viện Y học cổ truyền Cần Thơ. Đối tượng và phương pháp: Nghiên cứu hồi cứu cắt ngang tất cả hồ sơ bệnh án nội trú có sử dụng vị thuốc Hoàng Kỳ từ tháng 1 năm 2021 tới tháng 2 năm 2021 tại Bệnh viện Y học cổ truyền Cần Thơ. Kết quả: Độ tuổi trung bình trong nghiên cứu là 60±12,101 (20-89 tuổi), nam giới chiếm 58,1%, tỷ lệ nam/nữ: 1,38/1. Đa số ở độ tuổi trung niên (55-64 tuổi) chiếm 37,6%. Bệnh cảnh chủ yếu do Di chứng đột quỵ (65,7%), Thoái hóa khớp (17,2%). Các bệnh kèm theo chính là Tăng huyết áp (75,3%), Đái tháo đường type II (21,5%), RLLP máu (18,3%). Bệnh cảnh theo YHCT chủ yếu là Bán thân bất toại (64,5%), Chứng tý (18,3%). Phương dược điều trị chính là Đối chứng lập phương (46,2%) và Bổ dưỡng hoàn ngũ thang (39,9%). Liều Hoàng kỳ dùng nhiều nhất là 30g với tỉ lệ 51,6%. Kết luận: Kết quả bước đầu khảo sát cho thấy Hoàng kỳ xuất hiện chủ yếu trong các bài thuốc đối chứng lập phương, bài thuốc cổ phương Bổ dương hoàn ngũ thang dùng trong điều trị các bệnh như Bán thân bất toại, Chứng tý, Chứng nuy…., với tác dụng chính là Bổ khí, ích khí cố vệ với liều lượng trung bình từ 10-30g.
ĐIỀU TRỊ CHỬA TRÊN SẸO MỔ LẤY THAI BẰNG PHƯƠNG PHÁP TIÊM METHOTREXATE PHỐI HỢP HÚT THAI TẠI BỆNH VIỆN PHỤ SẢN HÀ NỘI
Authors: Thị Anh Đào Lê , Tuấn Đạt Đỗ
Published: April 2022

Chửa trên SMLT to trên 8 tuần tuổi còn chưa có phác đồ điều trị thống nhất. Mục tiêu: nhận xét kết quả điều trị chửa trên SMLT 8-10 tuần bằng phương pháp hút đơn thuần và hút phối hợp với methotrexate. Đối tượng và phương pháp nghiên cứu: nghiên cứu mô tả cắt ngang tiến cứu tại bệnh viện Phụ Sản Hà Nội. Các bệnh nhân chửa trên SMLT tuổi thai 8-10 tuần, có độ dày cơ tử cung tại vị trí vết mổ > 2mm được đánh giá nguy cơ chảy máu. Các trường hợp có nguy cơ chảy máu cao sẽ được diệt phôi và tiêm MTX toàn thân, sau đó tất cả được hút. Kết quả: Tiêm MTX tại túi ối và toàn thân làm βhCG giảm trung bình 135.673 mIU/ml. Tỷ lệ điều trị thành công của nhóm hút đơn thuần 93,1%, nhóm hút phối hợp MTX là 70%, tỷ lệ thành công chung 87,2 %. Kết luận: Phương pháp hút thai đơn thuần và hút thai phối hợp MTX là phương pháp điều trị hiệu quả với các trường hợp chửa trên SMLT 8-10 tuần.
O Contraditório no Código de Processo Civil de 2015 e as Ações Repetitivas decorrentes da Pandemia da Covid-19
Authors: Vissoky Rafaela , Jobim Marco
Published: April 2022

O presente artigo tem como escopo abordar o aumento significativo das ações repetitivas decorrentes da pandemia da COVID-19 e da relevância do respeito ao contraditório efetivo no Código de Processo Civil, mormente enquanto inserido neste instituto. No cenário atual e ante a intensa diversificação e multiplicidade das demandas que assolam o Poder Judiciário, requer-se o empreendimento de maiores esforços para a perfectibilização de uma tutela jurisdicional efetiva, em atenção aos critérios de celeridade e economia processual. Nesse contexto, pretende-se perpassar pelos conceitos de jurisdição, processo, ação e acesso à justiça no ordenamento jurídico brasileiro, para, então conceituar o direito fundamental do contraditório sob a égide do Código de Processo Civil, trazendo uma perspectiva histórica da evolução e da importância deste instituto. Na sequência, analisar-se-á a definição da pandemia da COVID-19 e seus respectivos impactos sob a perspectiva processual, seguindo pelas consequências jurídicas deste, incluindo a emergência das ações repetitivas. Posteriormente, passar-se-á à análise dos desafios do contraditório substancial perante os direitos coletivos, difusos e individuais e homogêneos, e finalmente, examinar-se-á o contraditório efetivo nas ações repetitivas decorrentes da pandemia da COVID-19. Palavras-chave: Jurisdição; Ações Repetitivas; Contraditório; Direito Processual Civil; Direitos Fundamentais; Tecnologia; Pandemia.
A justiça em praça pública: uma justiça para ou contra o
Authors: Carneiro Ana Teresa , Conceição Ana Raquel
Published: April 2022

Na presente publicação, as autoras analisam a influência da comunicação social na construção da justiça ou, pelo menos, na construção das perceções de justiça, por forma a perceber-se o real valor e contributo que aquela confere à opinião pública, e não apenas em relação ao simples cidadão, mas ainda quanto aos que detêm poderes de soberania em nome do povo. Mais especificamente, examinam o papel da comunicação social enquanto representante do pensamento dum povo e ainda a relevância da justiça em praça pública, quando comparada à exercida nas instituições detentoras da soberania popular. Da mesma forma, preocupam-se as autoras com a influência da comunicação social na livre convicção dos juízes e, consequentemente na tomada do juízo decisório, enquadrando aqui a possibilidade dum erro judicial potenciado pela comunicação social enquanto opinion maker. Nesta sede, procuram desmistificar o equilíbrio entre o direito público à informação e o interesse e a salvaguarda da reserva da vida privada de todos os intervenientes judiciários e, sobretudo, a salvaguarda dos interesses da justiça, que deverá sempre garantir um juízo decisório imparcial e independentemente. Palavras-chave: Comunicação social; Opinião pública; Juízo decisório; Justiça.
A protecção do whistleblower como mecanismo de combate à corrupção: notas sobre o estado da arte em Portugal
Authors: Ferreira Tania , Lambelho Ana
Published: April 2022

O reconhecimento de que as situações de corrupção, tão lesivas do interesse público, só podem ser efectivamente combatidas através do conhecimento da prática dos factos ilícitos planeados ou cometidos, e que esse conhecimento é, não raras vezes, difícil de obter, levou a uma reorientação do pensamento jurídico, procurando-se proteger sujeitos que, ainda que em desrespeito de um vínculo contratual, possam expor tais práticas. Com este trabalho pretendemos realizar um estudo introdutório sobre uma temática que se revela actual e de suma importância no combate à corrupção no seio empresarial – a protecção do whistleblower. Palavras-chave: Corrupção; Whistleblowing; Trabalhador, Lealdade.
A third-party funding: algumas reflexões
Authors: Mimoso Maria João
Published: April 2022

A escolha da arbitragem como modo de resolução de litígios entre empresas liga-se, essencialmente, às vantagens da arbitragem, designadamente celeridade processual, neutralidade do foro arbitral, confidencialidade, possibilidade da escolha de árbitros com conhecimentos técnicos precisos na área do litígio, de entre outras. As partes elegem a arbitragem como meio de resolução de litígios respeitantes a interesses de natureza patrimonial. Contudo, deveremos ter em atenção que, alguns legisladores, elegem a disponibilidade dos direitos como critério de arbitrabilidade. O pagamento das custas é condição sine qua non para a constituição do tribunal arbitral. As partes devem proceder ao pagamento das taxas, no caso da arbitragem institucionalizada, aos centros de arbitragem, e honorários aos árbitros que escolheram. Importa, ainda, referenciar que existem outros custos a ser contabilizados pelas partes, v.g. honorários dos mandatários no decurso da arbitragem. Considerando que a situação económica das empresas sofre oscilações ao longo da sua existência (designadamente, durante a execução de um contrato; aquando do surgimento de um litígio; no momento da constituição do tribunal arbitral; durante o iter processual) foi-se delineando a possibilidade de financiamento da arbitragem. Sendo que, atualmente, assume contornos muito precisos. Não podemos olvidar que, por vezes, o único ativo financeiro de uma empresa radica na expectativa de ganho de uma lide. Contudo, pode acontecer que a empresa não possua liquidez suficiente para instaurar a demanda. Como sabemos, em sede de foro arbitral, não é possível recorrer a apoio judiciário, pois estamos no âmbito de um modo de justiça privada, embora alternativa aos tribunais estaduais. A Third-Party Funding, TPF, surgiu para dar guarida a estes problemas. Trata-se de uma figura que envolve um terceiro, founder (financiador profissional) alheio ao litígio, que irá custear as despesas devidas por uma das partes na arbitragem. A sua contrapartida assentará, sobretudo, na participação no eventual resultado, financeiro, alcançado por via do êxito da arbitragem. Existem diversas modalidades de financiamento que importará analisar e delimitar de figuras afins. Como metodologia, além da análise do estado da arte, citaremos jurisprudência elucidativa para uma visão critica do problema. Avaliaremos, ainda, os motivos de crescimento do TPF, fruto da atual situação, não menosprezando as questões deontológicas e éticas atinentes aos mandatários das partes, aos árbitros e à entidade financiadora. Palavras-chave: Arbitragem; financiamento; empresas; despesas.
Determining the Degree of Fuzzy Regularity of a String
Authors:   Yerevan State University, Kostanyan Armen H.
Published: April 2022

The paper deals with the issue of determining the degree of fuzzy regularity of a crisp string. It is assumed that the concept of fuzzy regularity is formalized by a pattern given as a finite automaton with fuzzy properties of alphabet characters on transitions. Proceeding from this, we replace the problem of determining the degree of fuzzy regularity of a crisp string with the problem of determining the degree of belonging of such a string to the language of the corresponding automaton and propose an effective method for solving it using the dynamic programming approach. The solution to the considered problem makes it possible to fuzzify the set of strings in a given alphabet based on a pattern defining fuzzy regularity. This work is a continuation of the author’s previous works related to finding occurrences of a fuzzy pattern in the text. It may have applications in the field of pattern recognition, data clustering, bio-informatics, etc.
THE ROLE OF HOMOCYSTEIN AND OXIDATIVE STRESS IN PATHOGENESIS OF THE ENDOTHELIUM DYSFUNCTION IN CHILDREN WITH PYELONEPHRITIS
Authors: Vilchuk K. U.
Published: April 2022

80 per cent children with pyelonephritis (n = 80) revealed the endothelium dysfunction accompanied by a decrease of the endothelium-dependent vasodilation, associated with an increase in the homocysteine level and oxidative stress.
EXPERIMENTAL MODEL of hemorrhagic shock
Authors: Zyblev S. L. , Dundarov Z. A. , Martemyanova L. A.
Published: April 2022

Objectives : to develop and substantiate a new original method of modeling hemorrhagic shock in small laboratory animals. Materials and methods. Hemorrhagic shock was simulated on 32 nubilous outbred male albino rats (experimental group). The control group contained 30 healthy animals. Persistent hypotension was caused by 35-40 % intracardiac intake of circulating blood volume, which is about 5 ml of blood. The blood was taken by 2 ml/100 g per minute. The clinical and laboratory parameters of the animals were determined 24 and 48 hours later, then morphological studies were conducted, as well as the results obtained were compared with the control group. Results. All the laboratory animals of the experimental group observed tachypnea and tachycardia. The indices of red blood test in the experimental group reflected severity of blood loss by a statistically significant decrease of red blood cells and hemoglobin concentration during 48 hours compared to those in the control group. Thus, we obtained complex morphological confirmation of developed hemorrhagic shock. Conclusion. The presented model of hemorrhagic shock is maximum similar to natural processes which appear under normal conditions. With the help of the original model we can study pathogenetic mechanisms of hemorrhagic shock development, as well as to investigate the effect of various drugs and methods of treatment on the pathogenesis of shock. The proposed experimental model is simple in the technique of its performance and does not require expensive material and technical basis and is economically advantageous.
HepatocytIC differentiation of mesenchymal stem cells (literature review)
Authors: Skuratov A. G. , Petrenyov D. R. , Kondrachuk A. N.
Published: April 2022

The data of WHO indicate that liver diseases of different etiology are one of the 10 most frequent death causes in the world. Liver transplantation and use of its bioengineered analogs are limited by their high cost and adverse effects of the treatment, as well as by limited availability of donor organs and functional cellular elements. The application of innovative approaches of directed differentiation of mesenchyme stem cells can help overcome the shortcomings of current treatment methods. The present literature review covers the main sources, particularities of differentiation and safety aspects of the application of mesenchymal stem cell in the treatment of hepatic failure.
HISTOPHYSIOLOGY OF THE URINARY SYSTEM ORGANS
Authors: Solodova E. K. , Maximenko A. F.
Published: April 2022

The authors are presenting the lecture on the topic «Histophysiology of the urinary system organs» in English. The lecture was composed on the basis of foreign textbooks published in English for students of medical colleges and universities.
ВТОРИЧНЫЙ ГЕМОХРОМАТОЗ У ПАЦИЕНТА С МИЕЛОДИСПЛАСТИЧЕСКИМ СИНДРОМОМ (случай из клинической практики)
Authors: Конопляник О. В. , Жандаров М. Ю. , Мартемьянова Л. А.
Published: April 2022

В статье представлен случай вторичного гемохроматоза у пациента с миелодиспластическим синдромом в форме рефрактерной анемии. В основе поддерживающей терапии таких пациентов лежит заместительная терапия компонентами крови. Это облегчает симптомы анемии и, следовательно, является важным методом лечения. Вместе с тем многократные трансфузии компонентов крови повышают риск перегрузки организма железом, приводят к депонированию избытка его в клетках ретикулоэндотелиальной системы, прежде всего в печени, селезенке, железах внутренней секреции и сердце, поэтому главными осложнениями перегрузки железом являются заболевания сердца, печени и эндокринные нарушения.
NON-INVASIVE ASSESSMENT OF LEFT VENTRICULAR FILLING PRESSURE IN PATIENTS WITH AORTIC STENOSIS AND ISCHEMIC HEART DISEASE
Authors: Seyfidinova S. G.
Published: April 2022

Purpose: to assess left ventricular filling pressure (LVFP) in patients with aortic stenosis (AS) and ischemic heart disease (IHD) using methods of tissue Doppler imaging (figure E/Em) and impedance plethysmography (IP). Materials and methods . The study included three groups of patients: 40 with AS, 40 with IHD (constrictive coronarosclerosis) and 10 healthy people. In addition to the standard protocol echocardiography all the patients were examined using two survey methods for assessment of LVFP: tissue Doppler and IP. The statistical analysis of the material was performed using «Statistica», 6.0 for Windows. Results . The group with the AS was characterized by concentric hypertrophy of the left ventricular. The group with IHD was characterized by the mixed type of hypertrophy of the left ventricular and less significant growth of LVFP. Conclusion . In the AS group, the LVFP growth was determined according to the data of the two methods. In the IHD group, the LVFP growth was defined only by IP method which differentiates the two methods. The groups revealed the relation of LVFP (E/Em) with preload and the relation of LVFP (IP) with preload, afterload and left ventricular hypertrophy.
STATE OF BLOOD SERUM LIPID SPECTRUM IN THYROID DYSFUNCTIONS
Authors: Kapliyeva M. P. , Martusevich O. A. , Ukla A. A.
Published: April 2022

Objective: to study the features of lipid spectrum of blood serum in patients with hypothyroidysm and thyrotoxicosis depending on age, degree of compensation, duration of the illness and body mass index (BMI). Materials and methods . 70 patients with thyroid dysfunctions with various degree of compensation were included in the study. They were divided into 3 groups: the first group with primary subcompensated and decompensated hypothyroidysm; the second group with primary subcompensated and decompensated thyrotoxicosis, and the third group as a comparison group included patients in the state of medicamental compensation. The laboratory research was aimed at the definition of the indices of cholesterol (chol), triglycerides (TG), high density lipoproteins (HDLP), low density lipoproteins (LDLP), very low density lipoproteins (VLDLP) and quotient aterogenesity (QA) on the biochemical machine «Architect с8000» (ABBOOT, USA). Results. The analysis of the lipid spectrum depending on age in patients under 40 and over 50 revealed higher indices of chol and TG in the first group, than in the third one. The patients of the second group under 49 and over 60 had the same indices lower than in the patients of the third group. The patients of the first group who were in the state of decompensation observed the maximum indices of chol, TG, LDLP, VLDLP and QA. The patients of the second group in the state of decompensation had minimum deflection of the same indices of lipid spectrum. The patients of the first group observed increased indices of chol and TG in augmentation of the illness experience and the patients of the second group had the same indices decreased. The comparison of the data revealed minimum chol indices in the patients of the second group, and maximum TG indices in the first group in normal, boundary and increased BMI. Conclusion. The state of lipid spectrum in the patients with thyroid dysfunctions depended on the age of the patients, the experience of the illness, and BMI and compensation degree of thyroid functions which was confirmed by authentic correlation communications between the indices of free thyroxin and chol, TG and LDLP, and also between the thyroid stimulated hormone level and chol, TG, QA, LDLP and VLDLP indices.
EXPRESSION OF MARKER GENES BY HEPATOCYTE-LIKE CELLS differentiated from mesenchymal stem cells
Authors: Skuratov A. G. , Petrenyov D. R. , Kondrachuk A. N.
Published: April 2022

Objective: to investigate the expression of marker genes by hepatocyte-like cells differentiated from mesenchymal stem cells (MSCs). Materials and methods. Wistar white rats, bone marrow MSCs, isolated hepatocytes of the rats were obtained by enzymatic perfusion of liver; differentiation of MSCs in hepatocyte direction; light microscopy; investigation of expression of genes by polymerase chain reaction (PCR). Results. The observed changes in the gene expression profile during the stages of differentiation indicate the presence of the cells differentiated into hepatocytic direction in MSCs culture. The expression of Carbox, Krt18, Krt19 Cyt1A1 genes depends on the composition of the medium and is not permanent and inducible in nature. It is important to go on searching for the molecular markers of MSCs differentiation in the hepatocytic direction. These results demonstrate the necessity to systematize the available data on the changes in the levels of gene expression during MSCs differentiation into hepatocytes to unify the conditions of assessment of the gene expression profiling.
THE CHARACTERISTICS OF FRICTION OF WATTLED SURGICAL THREADS MADE FROM OF THE TRADITIONAL SUTURAL MATERIAL
Authors: Bontsevitch D. N. , Kaplan M. L.
Published: April 2022

Purpose: to study the characteristics of friction of wattled surgical threads made from traditional sutural material. Materials and methods . The friction of dry and wet threads was studied on the apparatus «ComTen 94C» by the original developed technique. We fixed a cylindrical mandrel with a diameter of 40 mm, wrapped up with a rag of suede skin 18 cm long between the captures in horizontal position. After fixing the end of the thread in a mobile capture of the test car we made one turn round the mandrel and suspended weight of 50 g to the second end of the thread. The speed of the mobile capture movements made up 100 mm/min. Results. The experimental tests revealed the best sample in the group - the surgical thread of Ethibond firm covered with polibutilate. The polymeric covering of the surgical threads «Supramid Ergon sutramed» makes it possible to achieve the optimum indicators of friction in the group of the threads made from caprone. The best sample among the surgical threads made from silk is a thread by Silkam B/Braun firm with a covering made from wax and silicone. Conclusion. The modification of surgical threads by drawing a covering makes it possible to achieve optimum indicators of friction, to improve the handling qualities and gives threads the quality of autraumatics.
ORGAN-PRESERVING SURGERY IN COUVELAIRE UTERUS
Authors: Einysh E. A. , Krot I. F. , Vakulchik I. O. , Kiriyanova B. L.
Published: April 2022

Couvelaire uterus is a rare complication of premature placental abruption. The article presents a brief literature review and describes a case of organ-preserving surgery in this complication. A pregnant patient in her thirty week was admitted to a maternity hospital with placental abruption and prenatally dead fetus. Cesarean section was performed and Couvelaire uterus was diagnosed during the operation. Taking into account the condition of the patient, her young age (20), absence of children, we performed organ-preserving surgery. The uterus was compressed with B-Lynch hemostatic suture. The patient was discharged from hospital on the eighth postoperative day without any complications. Menstrual function recovered after 3 months.
THE STATE OF BLOOD OXYGEN-TRANSPORT FUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION AND BRONCHIAL ASTHMA
Authors: Matveichyk A. I.
Published: April 2022

The aim of the study was to determine the condition of the blood oxygen-transport function in patients with arterial hypertension combined with bronchial asthma. 91 patients and 30 healthy individuals were examined. The blood oxygen-transport function was determined on the microaerotonometer «Syntesis-15» (Laboratory USA). The patients with arterial hypertension combined with asthma revealed an increase in oxygen affinity to hemoglobin, oxyhemoglobin dissociation curve shift to the left, an increasing degree of oxygenation of hemoglobin and the oxygen content in the venous blood. We identified the correlations between the parameters of the day monitoring of ambulatory blood pressure and blood oxygen.
THE LEVELS OF BIOGENIC AMINES IN THE BRAIN STRUCTURE OF RATS AFTER LONG-TERM ADMINISTRATION OF DINIL, LEAD ACETATE AND TAUZINC
Authors: Liakh I. V. , Sheibak V. M. , Doroshenko E. M. , Kremleva O. E. , Harshkova D. A.
Published: April 2022

Objective: to correct the levels of biogenic amines in the brain of rats having received lead acetate and dinil by Tauzinc. Material and methods. The content of biogenic amines in the brain of rats having received dinil (5 mg/kg) and lead acetate (30 mg/kg) separately and together with Tauzinc was studied by HPLC. Results. Chronic administration of lead and dinil leads to changes in the concentrations of biogenic amines in the midbrain and hypothalamus. The application of Tauzinc led to normalization of the serotonin concentration in the midbrain, as well as the turnover of serotonin in midbrain and the hypothalamus.
THE STRUCTURE OF ACUTE POISONINGS IN IN-PATIENTS
Authors: Vasilevich N. V. , Platoshkin E. N. , Zapolskiy D. V.
Published: April 2022

The article presents the structural and incidental analysis of acute poisonings in in-patients of the toxicological ward during the long period of time
ASSESSMENT OF EFFECTIVENESS OF FLUDARABINE-CONTAINING CHEMOTHERAPY PROGRAMS IN ONCOHEMATOLOGICAL PATIENTS
Authors: Kravchenko D. V. , Novik D. K.
Published: April 2022

Purpose: to assess effectiveness of fludarabine-containing chemotherapy programs in treatment of oncohematological patients after relapse or in primary chemoresistance. Material and methods. Within 2006-2013, 11 patients with various oncohematologic disorders were treated using fludarabine-containing high-dose chemotherapy programs FLAG or FLAG-Ida at the Republican Research Center for Radiation Medicine and Human Ecology. Results. The best results of this pilot study were obtained in the chemotherapy program FLAG-Ida. Remission was achieved in younger patients, in contrast to the group of elderly patients with no remission. All the patients who achieved remission were female, and among the 7 patients, who did not achieve remission, more than half were men. Conclusion. Thus, on the whole the fludarabine-containing programs of chemotherapy are effective in the treatment for oncohematological pathology, but further research is needed to develop a more differentiated approach to the application of the programs to improve the effectiveness of the therapy of these diseases.
THE SEX AND AGE DYNAMICS OF CARDIOVASCULAR PARAMETERS AND THEIR INTERCONNECTION WITH ANTHROPOMETRIC PARAMETERS IN CITY SCHOOLCHILDREN
Authors: Melnik V. A.
Published: April 2022

The article presents the data on the sex and age dynamics of the cardiovascular parameters in 1693 boys and 1757 girls of Gomel aged 7-17, examined within 2010-2012. Based on the data, centile tables were made up to assess the levels of systolic and diastolic pressure and heart rate. It was found out, that the periods of the maximum increase of the systolic pressure level in boys was recorded at the end of puberty, and in girls - before its beginning. The level of diastolic pressure considerably increased in the city schoolchildren of the both sexes at the end of the puberty period. The decrease of the heart rate was most considerably observed in boys aged 12-13, and in girls aged 9-10. The parameters of systolic pressure correlated more with the anthropometric features of body than the parameters of diastolic pressure and the heart rate.
FREE AMINOACIDS OF BLOOD PLASMA AND SPLEEN IN ADMINISTRATION OF LEAD ACETATE AND AMINO ACID-MICROELEMENT COMPOSITION «TRITARG» INTO ANIMALS
Authors: Sheibak V. M. , Pavliukovets A. Yu. , Smirnov V. Yu.
Published: April 2022

Objective: to develop protective properties of the amino acid-microelement composition «Tritarg» in experimental lead intoxication. Material and Methods. The experiments were conducted on white female rats. Free amino acids were tested by the reversed-phase HPLC. Results. Lead intoxication leads to a significant increase of total free amino acids and their nitrogen-containing metabolites in rats` blood plasma. The concentration of glutamate and proline, as well as the relative amount of aromatic amino acids increase in the spleen. The introgastric administration of «Tritarg» into rats treated with lead acetate, increased the level of hyperaminoacidemia and also stimulated the release of amino acids into cells and, probably, their metabolism in the spleen. Conclusion. The ten-day introgastric administration of «Tritarg» into the rats treated with lead acetate increases mobilization of free amino acids, as well as methionine, cystathionine, taurine in the blood plasma and spleen.
ANTIBACTERIAL EFFECT OF CATIONS ON HEAVY METALS
Authors: Savchenko O. I. , Kravchuk T. N. , Tapalsky D. V. , Filipova V. A.
Published: April 2022

Objective: to study bactericidal properties of metal cations against Staphylococcus aureus and Pseudomonas aeruginosa . Material and methods. Minimum inhibitory and minimum bactericidal concentrations of metal salts were determined by the method of broth dilution. The kinetics of growth and dying of S.aureus and P.aeruginosa was studied in broth culture medium in the presence of metal cations in concentrations four times exceeding the minimum bactericidal concentrations. Results. The cations of silver and copper proved to possess a marked bactericidal effect. It was showed that an increase of oxidation-reduction potential leads to an increase of the antibacterial efficiency of the metal cations. Conclusion. A relation of the oxidizing activity of the metal cations and their bactericidal action was revealed.
STRESS-INDUCED CHANGES OF ANTIOXIDANT ACTIVITY OF SPERM AND MORPHOLOGY OF TESTIS
Authors: Kidun K. A. , Solodova E. K. , Ugolnik T. S. , Doroshenko R. V.
Published: April 2022

Immobilization stress has physical and psycho-emotional effect on animals. Numerous authors noted the negative impact of this type of stress on the state of the male reproductive system. The present work shows the negative impact of short-term immobilization (3 hours) on the state of the sperm antioxidant status and the morphology of rats testis. The study was conducted on 24 sexually mature male outbred albino rats. The rats of the experimental group (n = 11) showed a reduction in the antioxidant status of the sperm. The animals exposed to immobilization stress observed morphological changes in the testis: reduced diameter of seminiferous tubules and thickness of the germinal layer, as well as violation of meiotic division in developing germ cells.
EFFECT OF ANGIOTENSIN-CONVERTING ENZYME GENE I/D POLYMORPHISM ON NEPHROPATHY IN DIABETIC PATIENTS
Authors: Vasilkova O. N. , Silin A. E. , Martinkov V. N. , Tropashko I. B. , Zekenova K. K. , Zhmailik M. V. , Mokhort T. V.
Published: April 2022

Aim: to study the relation of angiotensin-converting enzyme ACE (I/D) in genetic susceptibility of diabetic nephropathy (DN). Methods. I/D polymorphism of ACE gene was studied in 58 patients with diabetes type 2. Results. There are no reliable differences in detection of DD genotype and D allele in patients with DN and without DN (40,9 and 52,3 %, 19,4 and 41,7 %, respectively) (p = 0,076, LR = 0,313, 95 % DI = 0,084-1,164 for DD and p = 0,266, LR = 0,631, 95 % DI = 0,303-1,312 for D). Conclusion. The comparison of the results of genotyping in patients with and without DN did not reveal any differences in distribution of allele and ACE genotypes.
Fluorescence lidar observations of wildfire smoke inside cirrus: a contribution to smoke–cirrus interaction research
Authors: Veselovskii Igor , Hu Qiaoyun , Ansmann Albert , Goloub Philippe , Podvin Thierry , Korenskiy Mikhail
Published: April 2022

Abstract. A remote sensing method, based on fluorescence lidar measurements, that allows us to detect and to quantify the smoke content in the upper troposphere and lower stratosphere (UTLS) is presented. The unique point of this approach is
that smoke and cirrus properties are observed in the same air volume
simultaneously. In this article, we provide results of fluorescence and
multiwavelength Mie–Raman lidar measurements performed at ATOLL (ATmospheric Observation
at liLLe) observatory
from Laboratoire d'Optique Atmosphérique, University of Lille, during
strong smoke episodes in the summer and autumn seasons of 2020. The aerosol
fluorescence was induced by 355 nm laser radiation, and the fluorescence
backscattering was measured in a single spectral channel, centered at 466 nm and having 44 nm width. To estimate smoke particle properties, such as number, surface area and volume concentration, the conversion factors, which link the fluorescence backscattering and the smoke microphysical properties,
are derived from the synergy of multiwavelength Mie–Raman and fluorescence
lidar observations. Based on two case studies, we demonstrate that the
fluorescence lidar technique provides the possibility to estimate the smoke
surface area concentration within freshly formed cirrus layers. This value
was used in the smoke ice
nucleating particle (INP) parameterization scheme to predict ice crystal number
concentrations in cirrus generation cells.
Causal influences of El Niño–Southern Oscillation on global dust activities
Authors: Le Thanh , Bae Deg-Hyo
Published: April 2022

Abstract. The dust cycle is an important element of the Earth
system, and further understanding of the main drivers of dust emission,
transport, and deposition is necessary. The El Niño–Southern Oscillation
(ENSO) is the main source of interannual climate variability and is likely
to influence the dust cycle on a global scale. However, the causal
influences of ENSO on dust activities across the globe remain unclear. Here
we investigate the response of dust activities to ENSO using output from
Coupled Modeling Intercomparison Project Phase 6 (CMIP6) historical
simulations during the 1850–2014 period. The analyses consider the
confounding impacts of the Southern Annular Mode, the Indian Ocean Dipole,
and the North Atlantic Oscillation. Our results show that ENSO is an
important driver of dry and wet dust deposition over the Pacific, Indian, and
Southern oceans and parts of the Atlantic Ocean during 1850–2014. Over continents,
ENSO signature is found in America, Australia, parts of Asia, and Africa.
Further, ENSO displays significant impacts on dust aerosol optical depth
over oceans, implying the controls of ENSO on the transport of atmospheric
dust. Nevertheless, the results indicate that ENSO is unlikely to exhibit
causal impacts on regional dust emissions of major dust sources. While we
find high consensus across CMIP6 models in simulating the impacts of ENSO on
dust deposition and transport, there is little agreement between models for
the ENSO causal impacts on dust emission. Overall, the results emphasize the
important role of ENSO in global dust activities.
Orbital insolation variations, intrinsic climate variability, and Quaternary glaciations
Authors: Riechers Keno , Mitsui Takahito , Boers Niklas , Ghil Michael
Published: April 2022

Abstract. The relative role of external forcing and of intrinsic variability is a key question of climate variability in general and of our planet's paleoclimatic past in particular. Over the last 100 years since Milankovic's contributions, the importance of orbital forcing has been established for the period covering the last 2.6 Myr and the Quaternary glaciation cycles that took place during that time. A convincing case has also been made for the role of several internal mechanisms that are active on timescales both shorter and longer than the orbital ones. Such mechanisms clearly have a causal role in Dansgaard–Oeschger and Heinrich events, as well as in the mid-Pleistocene transition. We introduce herein a unified framework for the understanding of the orbital forcing's effects on the climate system's internal variability on timescales from thousands to millions of years. This framework relies on the fairly recent theory of non-autonomous and random dynamical systems, and it has so far been successfully applied in the climate sciences for problems like the El Niño–Southern Oscillation, the oceans' wind-driven circulation, and other problems on interannual to interdecadal timescales. Finally, we provide further examples of climate applications and present preliminary results of interest for the Quaternary glaciation cycles in general and the mid-Pleistocene transition in particular.
Delineating the distribution of mineral and peat soils at the landscape scale in northern boreal regions
Authors: Ågren Anneli M. , Hasselquist Eliza Maher , Stendahl Johan , Nilsson Mats B. , Paul Siddhartho S.
Published: April 2022

Abstract. A critical tool to succeed in sustainable spatial planning is accurate and detailed maps. To meet the sustainable development goals and enable sustainable management and protection of peatlands, there is a strong need for improving the mapping of peatlands. Here we present a novel approach to identify peat soils based on a high-resolution digital soil moisture map that was produced by combining airborne laser scanning-derived terrain indices and machine learning to model soil moisture at 2 m spatial resolution across the Swedish landscape with high accuracy (Kappa = 0.69, MCC = 0.68). As soil moisture is a key factor in peat formation, we fitted an empirical relationship between the thickness of the organic layer (measured at 5 479 soil plots across the country) and the continuous SLU soil moisture map (R2 = 0.66, p < 0.001). We generated categorical maps of peat occurrence using three different definitions of peat (30, 40 and 50 cm thickness of the organic layer) and a continuous map of organic layer thickness. The predicted peat maps had a higher overall quality (MCC = 0.69–0.73) compared to traditional quaternary deposits maps (MCC = 0.65) and topographical maps (MCC = 0.61) and captured the peatlands with a recall of ca 80 % compared to 50–70 % on the traditional maps. The predicted peat maps identified more peatland area than previous maps, and the areal coverage estimates fell within the same order as upscaling estimates from national field surveys. Our method was able to identify smaller peatlands resulting in more accurate maps of peat soils, which was not restricted to only large peatlands visible from airplanes – the historical approach of mapping. Most importantly we also provided a continuous map of the organic layer, which ranged 6–95 cm organic layer thickness, with an R2 of 0.67 and RMSE of 19 cm. The continuous map exhibits a smooth transition of organic layers from mineral soil to peat soils and likely provides a more natural representation of the distribution of soils. The continuous map also provides an intuitive uncertainty estimate in the delineation of peat soils, critically useful for sustainable spatial planning, e.g. green-house gas or biodiversity inventories and landscape ecological research.
Development and evaluation of an advanced National Air Quality Forecasting Capability using the NOAA Global Forecast System version 16
Authors: Campbell Patrick C. , Tang Youhua , Lee Pius , Baker Barry , Tong Daniel , Saylor Rick , Stein Ariel , Huang Jianping , Huang Ho-Chun , Strobach Edward , McQueen Jeff , Pan Li , Stajner Ivanka , Sims Jamese , Tirado-Delgado Jose , Jung Youngsun , Yang Fanglin , Spero Tanya L. , Gilliam Robert C.
Published: April 2022

Abstract. A new dynamical core, known as the Finite-Volume Cubed-Sphere (FV3) and
developed at both NASA and NOAA, is used in NOAA's Global Forecast System
(GFS) and in limited-area models for regional weather and air quality
applications. NOAA has also upgraded the operational FV3GFS to version 16
(GFSv16), which includes a number of significant developmental advances to the
model configuration, data assimilation, and underlying model physics,
particularly for atmospheric composition to weather feedback. Concurrent
with the GFSv16 upgrade, we couple the GFSv16 with the Community Multiscale
Air Quality (CMAQ) model to form an advanced version of the National Air
Quality Forecasting Capability (NAQFC) that will continue to protect human and
ecosystem health in the US. Here we describe the development of the
FV3GFSv16 coupling with a “state-of-the-science” CMAQ model version 5.3.1.
The GFS–CMAQ coupling is made possible by the seminal version of the
NOAA-EPA Atmosphere–Chemistry Coupler (NACC), which became a major piece of the next
operational NAQFC system (i.e., NACC-CMAQ) on 20 July 2021. NACC-CMAQ has a
number of scientific advancements that include satellite-based data
acquisition technology to improve land cover and soil characteristics and
inline wildfire smoke and dust predictions that are vital to predictions of
fine particulate matter (PM2.5) concentrations during hazardous
events affecting society, ecosystems, and human health. The GFS-driven
NACC-CMAQ model has significantly different meteorological and chemical
predictions compared to the previous operational NAQFC, where evaluation of
NACC-CMAQ shows generally improved near-surface ozone and PM2.5 predictions and diurnal patterns, both of which are extended to a 72 h
(3 d) forecast with this system.
Assessing the importance of conditioning factor selection in landslide susceptibility for the province of Belluno (region of Veneto, northeastern Italy)
Authors: Meena Sansar Raj , Puliero Silvia , Bhuyan Kushanav , Floris Mario , Catani Filippo
Published: April 2022

Abstract. In the domain of landslide risk science, landslide susceptibility mapping
(LSM) is very important, as it helps spatially identify potential
landslide-prone regions. This study used a statistical ensemble model
(frequency ratio and evidence belief function) and two machine learning (ML) models (random forest and XGBoost; eXtreme Gradient Boosting) for LSM in the province of Belluno (region of Veneto, northeastern Italy). The study investigated the importance of the conditioning factors in predicting landslide occurrences using the mentioned models. In this paper, we evaluated the importance of the conditioning factors in the overall prediction capabilities of the statistical and ML algorithms. By the trial-and-error method, we eliminated the least “important” features by using a common threshold of 0.30 for statistical and 0.03 for ML algorithms. Conclusively, we found that removing the least important features does not impact the overall accuracy of LSM for all three models. Based on the results of our study, the most commonly available features, for example, the topographic features, contributes to comparable results after removing the least important ones, namely the aspect plan and profile curvature, topographic wetness index (TWI), topographic roughness index (TRI), and normalized difference vegetation index (NDVI) in the case of the statistical model and the plan and profile curvature, TWI, and topographic position index (TPI) for ML algorithms. This confirms that the requirement for the important conditioning factor maps can be assessed based on the physiography of the region.
Real-time coastal flood hazard assessment using DEM-based hydrogeomorphic classifiers
Authors: Jafarzadegan Keighobad , Muñoz David F. , Moftakhari Hamed , Gutenson Joseph L. , Savant Gaurav , Moradkhani Hamid
Published: April 2022

Abstract. In the last decade, DEM-based classifiers based on height above nearest drainage (HAND) have been widely used for rapid flood hazard assessment,
demonstrating satisfactory performance for inland floods. The main limitation is the high sensitivity of HAND to the topography, which degrades the
accuracy of these methods in flat coastal regions. In addition, these methods are mostly used for a given return period and generate static hazard
maps for past flood events. To cope with these two limitations, here we modify HAND, propose a composite hydrogeomorphic index, and develop
hydrogeomorphic threshold operative curves for rapid real-time flood hazard assessment in coastal areas. We select the Savannah River delta as a
test bed, calibrate the proposed hydrogeomorphic index on Hurricane Matthew, and validate the performance of the developed operative curves for
Hurricane Irma. The hydrogeomorphic index is proposed as the multiplication of two normalized geomorphic features, HAND and distance to the nearest
drainage. The calibration procedure tests different combinations of the weights of these two features and determines the most appropriate index for
flood hazard mapping. Reference maps generated by a well-calibrated hydrodynamic model, the Delft3D FM model, are developed for different water
level return periods. For each specific return period, a threshold of the proposed hydrogeomorphic index that provides the maximum fit with the
relevant reference map is determined. The collection of hydrogeomorphic thresholds developed for different return periods is used to generate the
operative curves. Validation results demonstrate that the total cells misclassified by the proposed hydrogeomorphic threshold operative curves
(summation of overprediction and underprediction) are less than 20 % of the total area. The satisfactory accuracy of the validation results
indicates the high efficiency of our proposed methodology for fast and reliable estimation of hazard areas for an upcoming coastal flood event, which
can be beneficial for emergency responders and flood risk managers.
Gridded flood depth estimates from satellite-derived inundations
Authors: Bryant Seth , McGrath Heather , Boudreault Mathieu
Published: April 2022

Abstract. Canada's RADARSAT missions improve the potential to study past flood events; however, existing tools to derive flood depths from this remote-sensing data do not correct for errors, leading to poor estimates. To provide more accurate gridded depth estimates of historical flooding, a new tool is proposed that integrates Height Above Nearest Drainage and Cost
Allocation algorithms. This tool is tested against two trusted, hydraulically derived, gridded depths of recent floods in Canada. This validation shows the proposed tool outperforms existing tools and can provide more accurate estimates from minimal data without the need for complex physics-based models or expert judgement. With improvements in remote-sensing data, the tool proposed here can provide flood researchers and emergency managers accurate depths in near-real time.
Grand Challenges in the Design, Manufacture, and Operation of Future Wind Turbine Systems
Authors: Veers Paul , Bottasso Carlo , Manuel Lance , Naughton Jonathan , Pao Lucy , Paquette Joshua , Robertson Amy , Robinson Michael , Ananthan Shreyas , Barlas Athanasios , Bianchini Alessandro , Bredmose Henrik , Horcas Sergio González , Keller Jonathan , Madsen Helge Aagaard , Manwell James , Moriarty Patrick , Nolet Stephen , Rinker Jennifer
Published: April 2022

Abstract. Wind energy is foundational for achieving 100 % renewable electricity production and significant innovation is required as the grid expands and accommodates hybrid plant systems, energy-intensive products such as fuels, and a transitioning transportation sector. The sizable investments required for wind power plant development and integration make the financial and operational risks of change very high in all applications, but especially offshore. Dependence on a high level of modeling and simulation accuracy to mitigate risk and ensure operational performance is essential. Therefore, the modeling chain from the large-scale inflow down to the material microstructure, and all the steps in between, needs to predict how the wind turbine system will respond and perform to allow innovative solutions to enter commercial application. Critical unknowns in the design, manufacturing, and operability of future turbine and plant systems are articulated and recommendations for research action are laid out. This article focuses on the many unknowns that affect the ability to push the frontiers in the design of turbine and plant systems. Modern turbine rotors operate through the entire atmospheric boundary layer, outside the bounds of historic design assumptions, which requires reassessing design processes and approaches. Traditional aerodynamics and aeroelastic modeling approaches are pressing against the boundaries of applicability for the size and flexibility of future architectures and flow physics fundamentals. Offshore turbines have additional motion and hydrodynamic load drivers that are formidable modeling challenges requiring innovation. Uncertainty in turbine wakes complicates both structural loading and energy production estimates and requires advances in plant operations and flow control to achieve full energy capture and load alleviation potential. Opportunities in co-design can bring controls upstream into design optimization if captured in design-level models of the physical phenomena. It is a research challenge to integrate improved materials into the manufacture of ever-larger components while maintaining quality and reducing cost. High-performance computing used in high-fidelity, physics-resolving simulations offer opportunities to improve design tools through artificial intelligence and machine learning. Finally, key recommended actions needed to continue the progress of wind energy technology toward even lower cost and greater functionality are summarized.
First-Principles Study of Electronic and Dielectric Properties in Lanthanum Manganate
Authors: Omkar H. S. , Sreepad H. R.
Published: April 2022

First-principles calculations based on Density Functional Theory have been done on Lanthanum manganate. Its orthorhombic unit cell has been simulated. Electronic density of states has been computed and it shows that the material shows the nature of semiconducting material with a band gap of 1.38eV. Dielectric constant and Polarizability of the material have been computed. The value of dielectric constant comes out to be 47.3, 13.3 and 15.2 along X, Y and Z axes respectively with an average value of 25.3. The polarizability values are found to be 55.1(Å)3, 47.2(Å)3 and 48.5 (Å)3 along X, Y and Z axes respectively with an average value of 50.3(Å)3. Phonon modes at gamma point in the material range from 0 cm-1 to 885 cm-1.