bluuebunny/crossref_metadata_2025 huggingface dataset:
Hábitos de consumo y comercio electrónico en millennials de Lima – pandemia COVID-19/2021
Authors: Angulo Espinoza Vanessa Estefanía , Mongrut Tello Patricia del Pilar , Napán Yactayo Ana Cecilia
Published: October 2022

A nivel mundial, y, específicamente en el Perú como consecuencia de la pandemia por Covid-19, diversos tipos de conducta en el ser humano se vieron modificadas debido a las cuarentenas impuestas por el gobierno. Éstas significaron un cambio estricto en la modalidad en la cual los consumidores adquirían productos o servicios. Los millennials representan el 32,1% de la población de Lima Metropolitana. Éstos tuvieron que adaptar sus hábitos de consumo a las novedades que impuso el comercio electrónico. Es así como a partir del año 2021, el comercio electrónico cobró relevancia ante las restricciones de movilización de personas. Por tanto, desde el punto de vista de este estudio, el objetivo de la investigación considera “determinar si los hábitos de consumo se relacionan con el comercio electrónico en millennials de Lima – Pandemia Covid -19/2021”. Respecto a la metodología, se desarrolló el diseño no experimental, de corte transversal, enfoque cuantitativo y alcance descriptivo correlacional. La muestra fue probabilística calculada a través de la fórmula para proporciones poblacionales finitas con un resultado de 384 personas entre los 23 a 37 años (millennials). Para la obtención de datos se aplicó un cuestionario conformado por 28 ítems para ambas variables. Se trabajó con la prueba de normalidad de Rho de Spearman, encontrando correlaciones positivas bajas. Para la hipótesis general la correlación hallada fue de (r = 0,371) indicando que la relación es baja, concluyendo que los hábitos de consumo se relacionan significativamente con el comercio electrónico en millennials de Lima - Pandemia Covid-19/2021.
Graun Em Pulap Long Pipia: Rubbish, Sorcery, and Spiritual Healing, Papua New Guinea
Authors: Vávrová Daniela
Published: October 2022

Bapra Simi, an Ambonwari spiritual healer living in the border town of Vanimo in Papua New Guinea comments that the “Earth is full of rubbish” and associates this material overflow with the possible causes and consequences of sorcery. This short explanatory paper accompanies the video entitled Bapra Simi, Glasmeri, Spiritual Healer, Papua New Guinea (Vávrová, 2020), which follows Bapra Simi through her material and spiritual healing practices, and her articulation of how these practices are situated in the material and spiritual world.
Colonial Abandonment and Hurricane María: Puerto Rican Material Poetics as Survivance
Authors: González Melinda
Published: October 2022

In the wake of Hurricane María, Puerto Ricans in the tropical archipelago and the diaspora engaged in various forms of community organizing to confront governmental and social abandonment. Building on long-term ethnographic research and poetic analysis focused on the work of Puerto Rican poet Ana Portnoy Brimmer, I analyze poets’ critical and creative material practices that confronted histories of colonialism and engaged in forms of survivance post María (Vizenor, 2008). I argue that survivance is poiesis – a creative engagement in and with the world.  Through writing and performing poems, Puerto Ricans contested state narratives about the effects of the hurricane, documented their material and diasporic suffering, and made their lives more livable through accessing necessities, such as food and water, building and reconnecting with community, and bearing witness to each other’s lived experiences. Puerto Rican life and experiences are always entangled with their environment and material world. Thus, for Puerto Ricans, survivance as poiesis is a continuous affirmation of life in the face of ongoing disasters and death through material poetic practices.
Vernacular Virtual: Toward a Philippine New Materialist Poetics
Authors: Benitez Christian Jil
Published: October 2022

This essay turns to and through the Philippine vernacular in order to open up the possibility of a new materialist regard of literature, one that specifically stems from the Philippine tropics. It proposes that the opportunity for such a tropical materialism rests on the onomatopoeism observed in the vernacular. Onomatopoeia, as a material linguistic principle, is recognized here to be most instructive in reunderstanding Philippine folk poetry — texts which date back to the precolonial period — in terms beyond mere representation. As a counterpoint to these traditional literary texts, the essay also ruminates on the poetry of Jose Garcia Villa, a prominent Filipino modernist writer, whose works in English are intuited here as demonstrative of the similar onomatopoeism found in Philippine folk poems. Although these literary materials might initially appear to be disparate and disconnected, the reading undertaken here nevertheless seeks to coincide these texts, bringing them into relation to highlight their possible yet understated entanglements, so as to ultimately motivate an intra-activity constitutive of contingent spatiotemporalities that may allow the emergence of a groundwork for a Philippine new materialist poetics.
Square-Root Extended Information Filter for Visual-Inertial Odometry for Planetary Landing
Authors: Givens Matthew W. , McMahon Jay W.
Published: October 2022

A novel sequential information filter formulation for computationally efficient visual-inertial odometry and mapping is developed in this work and applied to a realistic moon landing scenario. Careful construction of the square-root information matrix, in contrast to the full information or covariance matrix, provides easy and exact mean and covariance recovery throughout operation. Compared to an equivalent extended Kalman filter implementation, which provides identical results, the proposed filter does not require explicit marginalization of past landmark states to maintain constant-time complexity. Whereas measurements to opportunistic visual features only provide relative state information, resulting in drift over time unless a priori mapped landmarks are identified and tracked, the tight coupling of the inertial measurement unit provides some inertial state information. The results are presented in a terrain-relative navigation simulation for both a purely orbital case (with no active propulsion) and a landing case with a constant thrust.
Dynamic Modeling and Attitude Control of Large-Scale Flexible Parallel Multibody Spacecraft
Authors: Li Yinkang , Li Shuang , Xin Ming
Published: October 2022

In this paper, modeling and high-precision attitude control of large-scale flexible parallel multibody spacecraft (FPMS) are addressed. First, for describing the complex constraint relationship between each body of the multibody system, the dynamic model of flexible spacecraft in the form of differential-algebraic equations (DAEs) is established by applying the Lagrange equation of the first kind (augmented Lagrange method). Then, to facilitate numerical integration of the dynamic model and controller design, an independent coordinate method and block matrix operation-based transformation method are proposed to convert DAEs into ordinary differential equations. Based on this model, a two-timescale composite controller is designed by virtue of the singular perturbation theory to attain high-precision attitude control of the FPMS and suppress the vibration of flexible appendages. Finally, numerical simulations are conducted under two mission scenarios to validate the dynamic model and demonstrate that the accurate attitude control can be achieved.
Finite-Wing and Sweep Effects on Transonic Buffet Behavior
Authors: D’Aguanno Alessandro , Schrijer Ferdinand F. J. , van Oudheusden Bas W.
Published: October 2022

This study experimentally investigates the effects of the sweep angle and finite wing on transonic buffet, studying two-dimensional (2-D) and three-dimensional wing configurations. Background-oriented schlieren and stereographic particle image velocimetry (PIV) have been used as measurement techniques, performing experiments on an OAT15A airfoil (clamped to both the side windows of the wind tunnel), an unswept wing, and two swept wings with sweep angles of 15 and 30 deg, respectively. The three wings are also based on the OAT15A airfoil and are clamped at the wind tunnel only at their root (free wingtip). All wings have been tested at a constant normal Mach number ([Formula: see text]) with respect to the leading edge. The results show that the buffet oscillations are much stronger for the airfoil than for the three finite-span wings. A large difference in the buffet behavior can be noticed between the airfoil and the unswept wing, as is also seen in oil flow visualizations. This difference is particularly evident in correspondence of the more outboard spanwise locations, suggesting that for the unswept wing, an important role could be played by finite-wing effects: notably, the tip vortex. A spectral analysis has shown that for the swept wings, the classical 2-D buffet peak (occurring at [Formula: see text] for the present conditions) is substantially attenuated, whereas additional contributions in the range of 450–850 Hz appear. The PIV results showed, for the 30 deg sweep angle wing, a periodical occurrence of a secondary supersonic area downstream of the main shock wave structure, which is absent for the other wing models. The stereographic PIV configuration allowed the reconstruction of the spanwise-oriented velocity component, obtaining, in proximity of the trailing-edge, values of the spanwise velocity component ([Formula: see text]) which are in agreement with the spanwise convection of buffet cells observed in the literature in this region.
IMPROVEMENT OF ELECTROSLAG SURFACE OF CHROME CAST IRON
Authors:   E.O. Paton Electric Welding Instituteof the National Academy of Sciences of Ukraine, Kuskov Yuriy , Lebedev Volodymyr ,   SF “Experimental Design-Technological Office of the E.O. Paton Electric Welding Institute of the National Academy ofSciences of Ukraine”, Zhdanov Volodymyr ,   E.O. Paton Electric Welding Instituteof the National Academy of Sciences of Ukraine
Published: October 2022

The main disadvantages of the existing methods of improving the strength of coatings, including the use of electroslag surfacing, on existing equipment structures to implement this process are considered. The task is to significantly improve the process of elec-troslag surfacing to ensure the desired operational strength of the coating and thus ensure the absence of cracks in the metal.It is shown that electroslag surfacing of chromium cast irons allowsto significantly improve their mechanical properties, in particular strength and to obtain defect-free high-quality welded metal for operational requirements. The use of current-carrying crystallizer expands the possibilities of use in the surfacing of different types of surfacing materials and regulating the structure and properties of the weld metal. The industrial experience of electroslag surfacing in the current-carrying crys-tallizer of rolled rolls with the use of chromium cast iron in the form of fractions and liquid additives, including chromium cast iron, is presented. A new direction in the development of surfacing works is shown -obtaining flat bimetallic blanks designed to strengthen fast-wearing surfaces.It is emphasized that a significant advantage of the current-carrying mold is its sectional design.Various schemes of realization of electroshack surfacing process both two-section and three-section with their features and definition with definition of the basic advantages and lacks are presented.This technology is quite promising and effective and can be proposed for wider implementation, due to the fact that there are relatively simple ways to implement surfacing.
THE EFFECT OF CARBON NANOTUBES MODIFICATION ON MICROSTRUCTURE AND FUNCTIONAL PROPERTIES OF POLYMER NANOCOMPOSITES BASED ON POLYETHYLENE
Authors:   Petro Mohyla Black Sea National Universit, Lysenkov Eduard
Published: October 2022

To expand the operational characteristics of polymer materials, nanofillers are introduced into their composition, one of the most promising is carbon nanotubes. However, the creation of such nanocomposite materials is associated with a number of difficulties, in particular with the need to evenly distribute the filler in the polymer matrix.One of the promising directions for solving the distribution problem is the functionalization of carbon nanotubes using various methods. Each method has its advantages and disadvantages. Most of them lead to the growth of only certain propertiesof materials, but their application is an expensive and time-consuming process.The analysis of research and publications in the field of improving the functional characteristics of polymer nanocomposite materials showed that the issue of non-covalent modification of carbon nanotubes and their use as a filler for the creation of structural materials is currently receiving little attention in the scientific literature.The purpose of this work is to improve the functional characteristics of polymer nanocomposite materials based on high-density polyethylene by means of non-covalent modification of carbon nanotubes introduced into their composition.The scientific article presents the results of studies of the microstructure and functional characteristics of polymer nanocomposite materials based on polyethylene by introducing modified carbon nanotubes into their composition. In order to improve the properties of the materials, nanotubes were modified using polyethylene glycol. Using the methods of optical microscopy, impedance spectroscopy and mechanical tests the microstructure, electrical and mechanical characteristics of polymer nanocomposite materials were investigated. It is shown that the non-covalent functionalization of CNTs by means of treatment with polyethylene glycol leads to a better distribution of nanotubes in the polymer matrix and an improvement of the electrical and mechanical properties of polyethylene-based nanocomposite materials.
ANALYSIS OF THE ELEVATOR DESIGN FOR PEOPLE WITH SPECIAL NEEDS AND ITS VISION IN THE FUTURE
Authors:   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Bieliaieva Anastasia , Verba Iryna ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Danylenko Oleksandr ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
Published: October 2022

The object of the study is a lift for people with special needs. The article is an overview and is devoted to the review of the construction of a lift for people with special needs, namely people who cannot stand up and/or move independently or people who have problems with the musculoskeletal system and vision for changing its functionality. It is assumed that the lift proposed inthis article will be equipped with a transforming chair and a remote control. Such a lift will help both people with special needs themselves and those around them who are forced to help with similar lifts. To do this, at the beginning of thearticle, different types of lifts are considered with all the characteristics, where the shortcomings of a particular device are clearly visible. Also selected lift, which is improving. The lift, chosen as the closest analogue, is intended for treatment with hydrotherapy. Therefore, it is suitable for moving a person from one point to another and letting down a person into the pool. However, this lift also has disadvantages, such as: a need of a person who will operate the lift; absence of a mechanism to help people get upright from sitting, because in this case there is no such need. Further, a device that changes the trajectory of the movement of the very arm of this lift, followed by an explanation of its operation is proposed. And the main goal is to develop a transforming chair, taking into account the height and weight of a person, as well as easy control and paying great attention to the safety of such a lift with a transforming chair, namely its stability and insurance of the person sitting in the chairof such alift when the patient's position changes. A remote control will also be offered with large buttons, voice and simple controlsfor easy self-use by a person with special needs, allowing it to be used by a wider range of patients
DEVELOPMENT NEW METHOD OF DEFORMATION INGOTS BASED ON FORGING OF PROFILED WORKPIECES
Authors:   Donbass State Engineering Academ, Markov Oleg , Khvashchynskyi Anton ,   Donbass State Engineering Academy, Musorin Anton ,   Donbass State Engineering Academy, Markova Marina ,   Donbass State Engineering Academy, Zhytnikov Roman ,   Donbass State Engineering Academy
Published: October 2022

Quantity of massive parts produced from an ingot is increasing today. It is caused by increasing of a massive equipment powerful. However, the quality of produced forging parts does not corresponds to customer`s requirements.Poor quality of the produced forging parts is caused by low quality of forging ingots.Defects of ultrasonic test after forging of the massive forging parts equal to 10%. The defects after ultrasonic test are caused by upsetting operation of the ingots with no equal internal structure. As a result, internal structure is processed unevenly and insufficiently. Increasing of the ingot internal defects occurs during upsetting operation of billets by flat deformationtools.The purpose of this work is establishing the rational geometry of billets with conical faces which guarantee the welding of the axial defects during upsetting operation.Rising diameter of conical face provide decreasing of defect welding degree. The toll conical faces rise the degree of thewelding defects. It was established that decreasing of the diameter and rising of the height the conical faces provide to reduction of convexity of the workpiece. In the initial step of the upsetting operation the “double convexity” is occurred. The convexity is growing at the diameter decrease of the conical faces. The “double convexity” levels out and the external surface of the workpiece obtains the nearly cylindrical shape in the finish upsetting. The relative height and diameter of the conical faceshave to be 0.4...0.6 and 0.5...0.7 respectively concerning the welding defects and equable distribution of the deformations at the upsetting. Obtained data of the upsetting in the manufactured conditions verified the established technological recommendations ofthe workpiece shape and dimensions obtained by theoretical modeling.
Doença Hemolítica Perinatal
Authors: Santos José Levy Silva dos , Pinto Ana Paula Oliveira
Published: October 2022

Objetivo: Analisar de que forma a Doença Hemolítica Perinatal (DHPN) se desenvolve, com enfoque ao sistema RhD; mostrar as consequências da doença hemolítica perinatal, identificar as pacientes suscetíveis e discorrer sobre métodos de profilaxia, levando em consideração o problema de saúde pública em que se encontra. Revisão bibliográfica: A DHPN também chamada de aloimunização está relacionada aos sistemas ABO e Rh, levando a um processo de sensibilização e produção de anticorpos direcionados aos antígenos eritrocitários fetais, desenvolvendo um processo de hemólise e suas repercussões, que pode ser desde anemia até insuficiência cardíaca, hidropisia e, por fim, óbito fetal. A Aloimunização é resultado da síntese de anticorpos maternos contra antígenos presentes nos eritrócitos fetais, por alguma incompatibilidade sanguínea feto materna. Considerações finais: Apesar dos avanços no manejo e tratamento, o mais importante é a prevenção, a fim de se evitar riscos fetais próprios do tratamento, bem como os custos elevados relacionados ao acompanhamento desses casos, até mesmo os desfechos adversos.
Nakit Akış Riskinin Sermaye Yapısı Kararlarına Etkisi
Authors: AKARÇAY Mehmet , ERSOY Ersan
Published: October 2022

Bu çalışmanın amacı, BIST 100 Endeksi’nde yer alan işletmelerde (finansal kuruluşlar hariç) nakit akış riskinin sermaye yapısı kararları üzerine etkisini araştırmaktır. 2004-2018 döneminde 61 işletmenin çeyrek dönemlik mali tablo verileri kullanılmıştır. Panel regresyon yönteminin kullanıldığı çalışmada, kaldıraç oranı ile nakit akış riski ve karlılık oranı arasında negatif yönde, kaldıraç oranı ile Piyasa Değeri/Defter Değeri oranı ve firma büyüklüğü arasında ise pozitif yönde ve istatistiksel olarak anlamlı bir ilişki bulunmuştur. Kaldıraç oranı ile maddi duran varlıkların toplam varlıklara oranı ve beklenen enflasyon arasında istatistiksel olarak anlamlı bir ilişki bulunamamıştır. Analiz sonuçlarına göre, nakit akış riski sermaye yapısının belirleyicilerinden biridir ve sermaye yapısına ilişkin kararlarda dikkate alınması gereken bir faktördür. Nakit akış riskinde bir artış yaşandığında işletmeler daha az borç kullanma eğiliminde olmaktadır ve dolayısıyla nakit akış riskindeki artış sermaye yapısı kararlarında özkaynaklar lehine değişime yol açmaktadır. Büyüme fırsatları (Piyasa Değeri/Defter Değeri oranı) arttıkça, işletmeler daha fazla borçlanmaktadır, diğer bir ifadeyle yeni yatırımların finansmanında borçla finansmanı tercih etmektedirler. İşletmeler, karlılık oranlarında yükseliş olduğunda öz kaynak ile finansmanı, karlılık oranında düşüş olduğunda ise borçla finansmanı tercih etmektedir. Firma büyüklüğünün artması halinde, işletmelerin borç kullanım düzeyleri yükselmektedir.
Laboratory Study On The Utilization of Jackruit Skin Waste Into Car-boxymethyl Cellulose and Their Effect On The Rheological Properties Of Drilling Mud
Authors: Novrianti Novrianti , Novriansyah Adi , Khalid Idham , Amani Zata Dini
Published: October 2022

The value rheology of drilling mud must be in accordance with the conditions of wellbore that do not lead to the occurrence of the problems at the time of drilling.  One of the efforts to improve the rheology of drilling mud is by adding Carboxymethyl Cellulose (CMC) which is useful for increasing viscosity and binding water. This study aims to identify the effect on the use of CMC originating from jackfruit skin to the rheological properties of drilling mud. Jackfruit skin is an underutilized organic waste and the structure of jackfruit skin contains 50-55% cellulose. Manufacturing phase of synthesizing CMC skin jackfruit includes the process of delignification, alkalization, carboximetilation, and sieve sample to be powdered CMC and subsequently carried out the test of plastic viscosity, yield point , gel strength by using a Fann VG Meter and mud cake using a marsh funnel and volume filtration using a filter press . The added mass of CMC jackfruit skin were varied from 1 g, 2 g, 3 g, 4 g to 5 g. The results suggest that the addition of jackfruit skin CMC has an effect on the rheology of drilling mud. Increasingly many additions additive CMC skin jackfruit who use the increasingly high- value rheology mud drilling were obtained. Furthermore, the addition of CMC jackfruit skin starting from 1gr – 5 gr meets the API 13, a standard for the value of yield point/viscosity plastic, plastic viscosity and maximum volume of filtrate. While the value of gel strength which meets the API 13 A is with the addition of CMC jackfruit skin as much as 5 grams.
IMPLEMENTASI MODEL PROJECT BASED LEARNING DALAM RANGKA MENINGKATKAN KEMAMPUAN BERPIKIR KREATIF
Authors: Mulyana Eldi , Juariah Juariah , Suherman Ade , Widyanti Triani , Supriyatna Asep
Published: October 2022

ABSTRAKPenelitian ini dilakukan di SMPN 4 Tarogong Kidul Garut. Hasil studi pendahuluan menunjukan bahwa berfikir kreatif SMPN 4 Tarogong kidul Garut belum optimal, di duga karena model pembelajaran project based learning yang belum optimal. Berangkat dari fenomena diatas, penelitian ini bertujuan untuk mengetahui apakah ada pengaruh model project based learning terhadap kemampuan berpikir kreatif di SMPN 4 Tarogong Kidul Garut. Metode penelitian yang digunakan adalah metode kuantitatif, dengan design penelitian yaitu pre exsperimental design yang digunakan yaitu uji validitas, uji reliabelitas, uji normalitas, uji beda paired T-Test, uji gain dan uji regresi untuk mengetahui ada tidaknya pengaruh model pembelajaran project based learning terhadap kemampuan berpikir kreatif. Dalam oprasionalisasinya digunakan bantuan software SPSS 22 dan Microsoft Excel. Hasil penelitian menunjukan bahwa terdapat perbedaan mean pada kemampuan berpikir kreatif peserta didik sebelum dan sesudah diberikan treatment dan terdapat pengaruh dari model pembelajaran project based learning terhadap kemampuan berpikir kreatif yaitu sebesar 37,7%, dan pengaruhnya signifikan dengan nilai 0,004.Kata kunci: Model pembelajaran project based learning, Kemampuan berpikir kreatif, Pendidikan IPS.
Lenalidomide stabilizes protein-protein complexes by turning labile intermolecular H-bonds into robust interactions
Authors: Miñarro-Lleonar Marina , Bertran-Mostazo Andrea , Duro Jorge , Barril Xavier , Juárez-Jiménez Jordi
Published: October 2022

Targeted protein degradation (TPD) is emerging as a very promising strategy to modulate protein activities in several diseases, spearheaded by anti–myeloma drugs lenalidomide and pomalidomide. It has been recently demonstrated that the mechanism of action of these drugs involves the increased degradation of several proteins, including the transcription factors Ikaros and Aiolos as well as the enzyme Caseine Kinase 1 alpha (CK1a). It has been shown that lenalidomide and pomalidomide are able to stabilize the complex between the E3 ligase Cereblon (CRL4CRBN) and the aforementioned proteins, while, remarkably, the stability of the protein-protein interaction is very low. Even though the structures for these complexes have been determined, there are no evident interactions that can account for the high formation efficiency of the ternary complex. In this work, we have leveraged Molecular Dynamics to shed light into the molecular determinants underlying the stabilization effect exerted by lenalidomide in the complex between CRL4CRBN and CK1a. Furthermore, we evaluated the effect that different mutations of CK1a in the stability of the ternary complex CRL4CRBN–lenalidomide–CK1a and provide a thermodynamic and kinetic rational for the stabilization effect. These results pave the way to further understand cooperativity effects in drug–induced protein–protein complexes and could help in the future design of improved targeted molecular degraders.
Spin Crossover Induced By Changing the Identity Of the Secondary Metal Species In A Face-Centred FeII8NiII6 Cubic Cage
Authors: Min Hyunsung , Craze Alexander R. , Wallis Matthew J. , Tokunaga Ryuya , Taira Takahiro , Hirai Yutaka , Bhadbhade Mohan M. , Fanna Daniel J. , Marjo Christopher E. , Hayami Shinya , Lindoy Leonard F. , Li Feng
Published: October 2022

The assembly of multifunctional polynuclear coordination cages exhibiting spin-crossover (SCO) proves to be a challenge to researchers. Previous investigations into the magnetic properties of a large cubic metallosupramolecular cage, [Fe8Pd6L8]28+, constructed using semi-rigid metalloligands and encompassing an internal void of 41 Å3, found that the Fe(II) centres that occupied the corners of the cubic structure did not undergo a spin-transition. In this work, substitution of the linker metal on the face of the cage resulted in the onset of spin crossover, as evidenced by magnetic susceptibility, Mӧssbauer and single crystal X-ray diffraction. Structural comparisons of these two cages were undertaken to shed light on the possible mechanism responsible for switching of the [Fe8M(II)6L8]28+ architecture from SCO inactive to active by simply changing in the identity of M(II). This led to the suggestion that a possible interplay of intra- and intermolecular interactions may permit SCO in the Ni(II) analogue, 1. The distorted octahedral coordination environment of the secondary Ni(II) centres occupying the cage faces provided conformational flexibility for the eight metalloligands of the cubic architecture relative to the square planar Pd(II) environment. Meanwhile the occupation of axial coordination sites of the Ni(II) cations by CH3CN prevented the close packing of cages observed for the Pd(II) analogue, leading to a more offset, distant packing arrangement of cages in the lattice, whereby important areas of the cage that were shown to change most dramatically with SCO experienced a lesser degree of steric hindrance to conformational changes upon SCO. Design through selectivity of secondary metal centres on the flexibility of metalloligand structures and the effect of axial donors packing arrangements may serve as new routes in the engineering of SCO or non-SCO cage systems.
Pseudo-irreversible butyrylcholinesterase inhibitors: structure–activity relationships, and kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead
Authors: Meden Anže , Knez Damijan , Brazzolotto Xavier , Modeste Fabrice , Perdih Andrej , Pišlar Anja , Zorman Maša , Denic Milica , Pajk Stane , Nachon Florian , Gobec Stanislav
Published: October 2022

Alongside reversible butyrylcholinesterase inhibitors, a plethora of covalent butyrylcholinesterase inhibitors have been reported in the literature, typically pseudo-irreversible carbamates. For these latter, however, most cases lack full confirmation of their covalent mode of action. Additionally, the available reports regarding the structure–activity relationships of the O-arylcarbamate warhead are incomplete. Therefore, a follow-up on a series of pseudo-irreversible covalent carbamate human butyrylcholinesterase inhibitors and the structure–activity relationships of the N-dialkyl O-arylcarbamate warhead are presented in this study. The covalent mechanism of binding was tested by IC50 time-dependency profiles, and sequentially and increasingly confirmed by kinetic analysis, whole protein LC-MS, and crystallographic analysis. Computational studies provided valuable insights into steric constraints and identified problematic, bulky carbamate warheads that cannot reach and carbamoylate the catalytic Ser198. Quantum mechanical calculations provided further evidence that steric effects appear to be a key factor in determining the covalent binding behaviour of these carbamate cholinesterase inhibitors and their duration of action. Additionally, the introduction of a clickable terminal alkyne moiety into one of the carbamate N-substituents and in situ derivatisation with azide-containing fluorophore enabled fluorescent labelling of plasma human butyrylcholinesterase. This proof-of-concept study highlights the potential of this novel approach and for these compounds to be further developed as clickable molecular probes for investigating tissue localisation and activity of cholinesterases.
Variable Kinetic Isotope Effect Reveals Multi-step Pathway for Protonolysis of a Pt–Me Bond
Authors: Rettig Irving , Xu Jingtong , Knight Elizabeth , Truong Phan , Bowring Miriam
Published: October 2022

The reaction of (cod)PtMe2 (cod = 1,5-cyclooctadiene) with trifluoroacetic acid (TFAH) to release methane is an important system because it represents the microscopic reverse of desirable methane activation, and because it has an unusually large kinetic isotope effect (KIE) that has been tentatively attributed to proton tunneling. A detailed kinetic and mechanistic inves-tigation of this system was conducted using stopped-flow and traditional time-dependent UV-vis spectroscopy, supported by NMR and DFT studies. Consistently large KIE values (~14) in line with previous reports were obtained over a large range of reactant concentrations (0.1 – 1.6 mM (cod)PtMe2 and 3.2 mM to 6.0 M acid). At lower concentrations of acid, the KIE decreased significantly (KIE = ~6 for 0.1 mM (cod)PtMe2 and 0.2 mM acid). This concentration-dependent KIE suggests a multi-step reaction mechanism, eliminating the need to invoke proton tunneling. The reaction exhibits first-order dependence on (cod)PtMe2 and approximately second-order dependence on acid, with at least 2 equivalents of acid required for complete conversion. Overall, the kinetic data indicate a multi-molecular, multi-step reaction mechanism for the protonolysis of (cod)PtMe2, thus ruling out the previously accepted bimolecular single-step mechanism. A mechanistic alternative consistent with the kinetic data is proposed, in which sequential oxidative addition and reductive elimination occur, and the second equivalent of acid serves to stabilize trifluoroacetate anion in solution.
Portfolio optimization based on self-organizing maps clustering and genetics algorithm
Authors: Farid Fajri , Rosadi Dedi
Published: October 2022

In this modern era, gaining additional income is necessary to fulfill daily needs since inflation is unavoidable. Investing in stocks can give passive income to help people deal with the increasing prices of necessities. However, selecting stocks and constructing a portfolio is the major problem in investing. This research will illustrate the stock selection method and the optimization method for optimizing the portfolio. Stock selection is carried out by clustering using Self-organizing Maps (SOM). Clustering will show the best stocks formed for a portfolio to be optimized. The best stocks that have the best performance are selected from each cluster for the portfolio. The best performance of the stock can be determined using the Sharpe Ratio. Optimization will be carried out using a Genetic Algorithm. The optimization is carried out using software R i386 3.6.1. The optimization results are then compared to the Markowitz Theory to show which method is better. The expected return on the portfolio generated using Genetic Algorithm and Markowitz Theory are 3.348458 and 3.347559975, respectively. While, the value of the Sharpe Ratio is 0.1393076 and 0.13929785, respectively. Based on the results, the best performance of the portfolio is the portfolio produced using Genetic Algorithm with the greater value of the Sharpe Ratio. Furthermore, the Genetics Algorithm optimization is more optimal than the Markowitz Theory.
Covid-19 detection from chest x-ray images: comparison of well-established convolutional neural networks models
Authors: As'ari Muhammad Amir , Manap Nur Izzaty Ab
Published: October 2022

Coronavirus disease 19 (Covid-19) is a pandemic disease that has already killed hundred thousands of people and infected millions more. At the climax disease Covid-19, this virus will lead to pneumonia and result in a fatality in extreme cases. COVID-19 provides radiological cues that can be easily detected using chest X-rays, which distinguishes it from other types of pneumonic disease. Recently, there are several studies using the CNN model only focused on developing binary classifier that classify between Covid-19 and normal chest X-ray. However, no previous studies have ever made a comparison between the performances of some of the established pre-trained CNN models that involving multi-classes including Covid-19, Pneumonia and Normal chest X-ray. Therefore, this study focused on formulating an automated system to detect Covid-19 from chest X-Ray images by four established and powerful CNN models AlexNet, GoogleNet, ResNet-18 and SqueezeNet and the performance of each of the models were compared. A total of 21,252 chest X-ray images from various sources were pre-processed and trained for the transfer learning-based classification task, which included Covid-19, bacterial pneumonia, viral pneumonia, and normal chest x-ray images. In conclusion, this study revealed that all models successfully classify Covid-19 and other pneumonia at an accuracy of more than 78.5%, and the test results revealed that GoogleNet outperforms other models for achieved accuracy of 91.0%, precision of 85.6%, sensitivity of 85.3%, and F1 score of 85.4%.
Development of a management accounting model of an insurance company using dashboards
Authors: Merkulova T. , Ihumentseva N. , Prokopenko A.
Published: October 2022

Modern enterprise resource management systems are quite universal, but in practice each firm has its own characteristics, which are determined by the type of activity, scale of production, management structure and other factors. These features must be taken into account when choosing a model of management accounting, adapting it to the requirements of production and management of a particular enterprise. This paper focuses on the development of a model of management reporting of an insurance company based on the 1C: Enterprise system using dashboards. Based on the needs of company management, the requirements for the model of management reporting were formulated: simplicity and clarity; control of key indicators; choice of time intervals; comparison of locations (branches, separate offices, sites, etc.); taking into account exchange rates. The proposed conceptual model includes a system of key indicators, a block of preparatory information for dashboards, blocks of the 1C: Enterprise system (sources of information). The development of the model according to this conceptual scheme involves the following stages: the choice of key indicators; content development and design of dashboards; preparation of input information for dashboards. The proposed blocks of key indicators of the conceptual model were divided according to the content into 2 dashboards: dashboard of insurance indicators and dashboard of financial indicators. Dashboards use the following filters: month, location, and indicator. In the dashboard of financial indicators there is an additional filter "currency" (UAH, EUR, USD). The developed conceptual model of management reporting and its implementation with the help of dashboards can be a useful tool for the management of the insurance company. The model focuses on small firms, but takes into account the spatial structure of the company, the structure of insurance products, and time interval. Dashboards present in a simple and clear way relevant information that can be used in making management decisions.
Tax instruments of local budget revenue regulation
Authors: Sukach O. , Sarana L. , Gordienko L.
Published: October 2022

The decentralization of finance in the context of reform of local self-government in Ukraine needs the improvement of the tax system i.e. the optimal allocation of taxes between the local and state budgets. The purpose of this research is to enhance the existing experience of budget decentralization with the identification of the practical results of the decentralization reform and its impact on the local territorial communities in Ukraine. The article examines and summarizes the current experience of budget decentralization in Ukraine and the results of the reform, as well as their community impact. The main focus of the study is on the principles of tax policy implementation in terms of taxes and fees credited to local budgets. The purpose of the study is to optimize the tax mechanisms for filling local budgets in Ukraine. The article examines the state of filling local budgets and its impact on socio-economic development of the community. It is determined that the basis of revenues are tax revenues, the share of which is growing every year. The reform resulted in increased interest of local governments in increasing revenues to local budgets, finding reserves to fill them, improving the efficiency of administration of taxes and fees. Thus, the main budget-forming tax is the personal income tax, which in the amount of 60 percent is credited to the budgets of rural, township, urban territorial communities. In its turn, the positive dynamics is the reduction of intergovernmental transfers. Increasing the dependence of local budgets on personal income tax and own local taxes is a positive consequence of the implemented budget reform. According to the results of the study, the directions of optimizing the use of tax instruments in filling local budgets are substantiated. One of the crucial conditions for creating a highly developed market economy is the formation of local self-government as an effectively functioning part of the public sector.
Information and analytical technologies in trading enterprise management
Authors: Klepikova O. , Danylchuk J. , Zagray T.
Published: October 2022

The article considers economic and mathematical methods and information technologies for managing the processes of trade enterprise. Economic and mathematical models for solving warehousing logistics problems, stochastic and statistical models of inventory management, models of optimal management and queuing systems are analyzed. Flexible tools are used to increase the efficiency of trade enterprise management and timely decision-making. The tools combine the use of mathematical models, a simulation model and information-analytical technologies. The study was carried out in three stages. The simulation model is designed in the software iThink. The simulation model was used to forecast sales, incomes, expenses and profit, processes of goods purchases, which take into account the factors of seasonality and the rest of production both in a warehouse and in the enterprise as a whole. The efficiency indicators of the enterprise are calculated and the possibility of payroll depending on income and dividends to owners is analyzed. An investment project has been designed in the software «Alt-Invest». This project analyzes the possibility of opening a new store with regard for financial activities, the development of a business plan for an investment project, the preparation of financial feasibility study, and the assessment of the impact of external factors and internal parameters on the overall effectiveness of the project. A comparative assessment is carried out in order to select the most promising project option. ABC-XYZ scenario was designed in the software platform Loginom. Using this analysis, the product range was divided into groups depending on the revenue and financial capabilities of the enterprise.
Public finance as a component of the financial system
Authors: Shainoha A.
Published: October 2022

The article focuses on the analysis of the dynamics and current state of development of public finances in Ukraine. Theoretical aspects of the public finance system are considered, namely: their essence, functions and structure, as well as the modern public finance system of Ukraine, its structure and components. Public finance is a key component of Ukraine's financial system, which owns more than half of all financial resources and includes various financial institutions that perform state functions. The multifunctionality of public finances determines their extensive structure, the main component of which is the State Budget. The implementation of the State Budget of Ukraine for nine years (2013-2021) as a key component of public finances was analyzed. The analysis of the revenue and expenditure part of the State Budget of Ukraine for four years (2018-2021) was conducted, and the shortcomings of the formation and use of budget funds were identified.The study identified the main problems and shortcomings of the public finance system of Ukraine, where the central place is occupied by problems with the formation and use of budget funds and inefficient functioning, resulting in persistent budget deficits, rising debt burden and tax pressure on the population. To eliminate the budget deficit, it is necessary to reduce the number of expenditure items and conduct careful control over expenditures. This paper has developed proposals to improve the state and efficiency of the public finance system, eliminate existing problems of revising and reducing the share of expenditures, increase revenue through non-tax revenues and give autonomy to local governments, which will reduce excessive centralization of the budget system and improve financial position of the state.
CAMINHOS AVALIATIVOS NA EDUCAÇÃO BÁSICA: DIMENSÕES FORMATIVAS E PRÁTICAS
Authors: DE LOURDES DA SILVA NETA MARIA , MATOS MONTEIRO RACHEL RACHELLEY , SILVA CARNEIRO DOS SANTOS MARIA TERLA
Published: October 2022

Este texto versa sobre os caminhos avaliativos na Educação Básica, em articulação com as dimensões formativas e práticas durante o trabalho docente. O estudo contou com dez professores do ensino regular de escolas públicas do Estado do Ceará. Tivemos como objetivo central compreender as concepções docentes acerca da avaliação da aprendizagem na Educação Básica, refletindo sobre as práticas avaliativas no ambiente escolar e como principais suportes teóricos os estudos de Hoffmann (2014), Luckesi (2011), Silva Neta (2018) e Magalhães Junior (2015), dentre outros. Metodologicamente esta pesquisa orientou-se pela abordagem qualitativa, com o tipo de pesquisa estudo de caso múltiplo, utilizando-se de técnicas de coleta de dados bibliográfica e de campo com entrevistas semiestruturadas. Os resultados apontaram diferentes conceituações de avaliação, sendo prevalecente a concepção de avaliação como medida. O caráter reprodutivo de práticas de ensino espelhadas nos professores formadores e a ausência de estudos sobre avaliação nos cursos de formação de professores foram evidenciados. Os professores demonstraram desalinho na compreensão entre instrumentos e técnica e revelaram desconhecer os critérios que devem ser organizados previamente para nortear os instrumentos de avaliação, revelando, assim, ausência do conhecimento avaliativo, fundamental no exercício profissional da docência.
Omega-K Algorithm Using Plane Wave Approximation for Forward-Looking Imaging Radar
Authors: Cho Byunglae , Hong Sungwon , Yoon Kichul
Published: October 2022

We propose an Omega-K algorithm that uses plane wave approximation for image formation in forward-looking imaging radar (FIRA) with the multi-input/double-output configuration. We assume that each of the transmitting antennas is located at the center of the receiving antenna array by applying a virtual antenna array. Then, we solve numerical equations in an approximation of the plane wave with the direction normal to the antenna array. Finally, we can obtain an image by proceeding with the following steps in order: the matched filtering, Stolt interpolation, two-dimensional inverse fast Fourier transform, phase compensation, image registration, and image merging. The performance of the proposed algorithm is verified through a simulation and a real experiment with neighboring targets. The results show that the proposed Omega-K algorithm with plane wave approximation can be successfully applied to FIRA systems with bistatic synthetic aperture radar configuration.
A Neural Network-Based Microwave Imaging Method for Object Localization
Authors: Son Wonhyung , Park Won-Kwang , Son Seong-Ho
Published: October 2022

This paper presents a new microwave imaging method using artificial neural networks to localize an object. The trained neural network reconstructs a tomographic image from the measured scattering data, such as a nonlinear electromagnetic inverse scattering solver. The appropriate number of hidden neurons is determined through the cross-entropy between network predictions and target values. To verify this method experimentally, we set up a testbed consisting of 16 antennas that transmit and receive 950 MHz microwaves underwater and used a metal rod with a diameter of 2 mm as a localizing target. The results show excellent imaging performance with fewer artifacts and less than a 2-mm localization error.