bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Cigarette Smoking on Serum Cystatin C and Creatinine Levels and MAU: A Case-Control Study
Authors: Farah Nizar , Abbas Anass , Alameen Ayman , Shalabi Manar , Elderdery Abozer , Eltayeb Lienda , Babker Asaad , Mohamed Hatem , Aedh Abdullah
Published: March 2023

Background: Smoking-related hemodynamic events may adversely influence renal function. The aim of this study was to evaluate renal impairment biomarkers among healthy people influenced by cigarette smoke. Methods and Results: In this case-control study, 90 subjects were enrolled: 60 were smokers, and 30 were non-smokers (apparently healthy control). Serum CysC was measured using a semi-automated, specific protein analyzer Mispa-i2 (Germany). Serum creatinine and MAU were assayed in the fully automated biochemistry analyzer (Mindray BS380). The mean concentration of CysC was significantly higher in cigarette smokers than in non-smokers (0.793±0.125 vs. 0.619±0.103, P=0.000). Also, the mean of MAU and serum creatinine levels were significantly higher in cigarette smokers than in non-smokers (18.33±3.41 vs. 12.70±0.517, 1.06±0.161 vs. 0.810±0.058, respectively, P=0.000 in both cases). The mean concentration of CysC and MAU was significantly greater in heavy smokers than in light smokers (P=0.000 and P=0.001, respectively). Serum CysC and MAU levels were positively correlated with the age of cigarette smokers (r=0.734 and r=0.730, respectively; P=0.000 in both cases) and the duration of smoking (r=0.773 and r=0.790, respectively; P=0.000 in both cases). Conclusion: cigarette smoking increases the specific renal biomarkers considered risk factors for renal impairment. Using such inflammatory biomarkers as diagnostic tools can be a necessary precaution in the development of chronic kidney disease caused by smoking and in the avoidance of acute renal consequences linked to cigarette smoking.
Expression of P53 and PTEN in Correlation with some Clinical and Pathological Features in Breast Cancer of Sudanese Patients
Authors: Hamad Abubaker , Alkhatem Rania , Algahany Asaad , Ahmed Hussain , Alfahed Abdulaziz , Waggiallah Hisham
Published: March 2023

The goal of our study was to determine the expression and phosphorylation of PTEN at residues Ser380/Thr382/383, as well as the nuclear expression of p53 in Sudanese patients with breast cancer (BC) in association with clinicopathological aspects of BC. Methods and Results: This retrospective, descriptive study was carried out in Wad-Madani, Gezira state in Sudan, from January 2015 to August 2016. A total of 179 biopsies were taken at random from patients with breast lesions. Two blocks were obtained for each patient. One came from a malignant lesion (Group A), whereas the other came from the margin adjacent to healthy tissue (Group B). Immunohistochemistry and immunofluorescent histochemistry were performed on two separate slides. We found a statistically significant difference in the frequency of immunohistochemical expression of p53 and phosphorylation of PTEN between the cancerous breast tissue and adjacent normal tissue. P53 and PTEN exhibited a significant relationship with each other and the grade of tumor, indicating their importance in the aggressiveness of breast lesions. It should also be emphasized that there is an association between p53 expression and lymph node metastasis, which indicates the involvement of p53 mutation in the metastasis of BC.
Analysis of NPM1 and FLT3 Mutations in Patients with Acute Myeloid Leukemia in Jeddah, Saudi Arabia: A Pilot Study
Authors: Raed Alserihi Raed Alserihi , Hameeda Ahmad Hameeda Ahmad , Heba Alkhatabi Heba Alkhatabi , Talal Qadah Talal Qadah , Shahad W. Kattan Shahad W. Kattan , Elrashed B. Yasin Elrashed B. Yasin , Haitham M. H. Qutob Haitham M. H. Qutob , Waleed M. Bawazir Waleed M. Bawazir , Abeer Fakhr-Eldeen Abeer Fakhr-Eldeen , Manal S. Fawzy Manal S. Fawzy , Ahmad S. Barefah Ahmad S. Barefah
Published: March 2023

Background: The outcome of acute myeloid leukemia (AML) is influenced by ethnicity, geographic variations, and the patient’s molecular profile. We aimed to explore the mutation frequencies of the nucleophosmin 1 (NPM1) and the FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) or tyrosine kinase domain (TKD) with correlation to the cytogenetic profiles in patients with AML. Methods and Results: Bone marrow/whole blood samples from 33 patients with AML were screened for NPM1/FLT3-ITD mutations by fragments analysis using a GeneScan analyzer. Depending on the fragment size, the NPM1 and FLT3 wild type (Wt) (170bp and 330bp) vs. mutated (170/174 bp and 330/351 bp) alleles, respectively, can be distinguished. The allelic ratio of FLT3-ITD⁺ was calculated. FLT3-TKD⁺ mutation was detected by Sanger sequencing. Samples were tested for chromosomal aberrations. According to the French-American-British (FAB) classification, the predominant type in the present cohort was AML-M5, accounting for 30.3%. NPM1⁺, FLT3-ITD⁺, and double mutations were found in 12.1%, 3.1%, and 6.1% of cases, respectively. The combined NPM1⁺/FLT3-ITD⁺/FLT3-TKD⁺ profile was presented in one patient (3.1%). The dual positivity group (NPM1⁺/FLT3⁺) significantly had a higher WBC count with a median of 81.3×103/µL. A total of 63.6% of patients had abnormal cytogenetics. The NPM1⁺/FLT3-ITD⁺ patients had normal karyotypes. Patients with NPM1-/FLT3- showed complex karyotype (24%) and t(8;21) (8%). The FLT3-ITD⁺ patient had trisomy 8. Conclusion: The frequency of NPM1/FLT3 mutations in the study cohort showed less rate than in other studies with a distinct pattern. Due to the preliminary nature of the present work, more extensive screening is warranted to evaluate their usefulness as prognostic indicators in this region.
The Application of Artificial Intelligence in Detecting Breast Lesions with Medical Imaging: A Literature Review
Authors: Alghamdi Salem Saeed
Published: March 2023

Breast cancer is considered the most commonly diagnosed cancer among women worldwide. Several studies have shown that mammography screening could significantly decrease breast cancer mortality. Despite other screening modalities, such as MRI and ultrasound (US), mammography plays a vital role in detecting cancer and following up on it, due to its qualities and properties. The aim of this literature review is to look at recent studies that use AI with different medical imaging mammograms, MRI, and US, in detecting breast lesions. A literature search was carried out using Google Scholar, Semantic Scholar, medRxiv, and PubMed databases for a period of the last four years. The search terms were "breast lesion," "breast imaging," and "breast cancer" combined with "machine learning," "deep learning," and "artificial intelligence." Among these studies, only the medical imaging related to breast lesions with AI was selected. A total of 25 articles were extracted from the following databases: 4 Google Scholar, 3 Semantic Scholar, 4 medRxiv, and 14 PubMed. Only papers related to breast lesions with medical imaging modalities were extracted, and all duplications were removed. In this study, the papers were reviewed by medical imaging professionals. This literature review summarizes the most recent articles on utilizing AI in detecting breast lesions for different imaging modalities: mammogram, ultrasound, and MRI. Reviewed studies showed that AI performance in detecting lesions was significant, associated with high accuracy, sensitivity, and specificity for these modalities.
Comparative Overview of Different Radiological Imaging Techniques in the Diagnosis of Pulmonary Embolism
Authors: Hamd Zuha
Published: March 2023

Background: Imaging techniques such as chest X-ray (CXR), computed tomography pulmonary angiography (CTPA), ventilation-perfusion (V/Q) scintigraphy, and magnetic resonance imaging (MRI) are some methods used to detect and manage acute pulmonary embolism (PE). The aim of this review was a comparative analysis of the various imaging techniques used to evaluate PE. Methods and Results: The incidence, distribution, clinical features, classification of PE and clinical assessment of the current methods for diagnosis of PE were discussed. CTPA is the gold standard for fast turnaround and accurate diagnosis. Additional probable reasons for sudden chest pain can also be learned through a CT scan. Lung perfusion anomalies can be identified and measured using dual-energy CT. Chest radiographs are only marginally beneficial, occasionally revealing PE or infarction signs, but are helpful in ruling out other possible causes of chest pain. These patients' ventilation-perfusion mismatches are evident in the V/Q scan, which has many grading schemes with conventional ranges from normal to high. While MRI, which is only available in specialist facilities and calls for higher degrees of competence, also offers accurate diagnosis. Conclusion: Early diagnosis and treatment of PE is challenging due to asymptomatic conditions or overlapping symptoms. Diagnosis of PE in expectant mothers and those with suspected PE recurrence is typically difficult. Over-diagnosis and overtreatment, particularly regarding sub-segmental PE, and the lowered clinical suspicion threshold remain a major concern in PE diagnosis. The routine use and integration of the above diagnostic techniques need to be encouraged in clinical practice to overcome the diagnostic hurdles. The introduction of new diagnostic techniques or improved risk stratification processes might enhance the management of PE.
A Bibliometric Analysis of Radicalization through Social Media
Authors: AKRAM Muhammad , NASAR Asim
Published: March 2023

The purpose of this study is to synthesize the literature relating to radicalization on social media, a space with enhanced concerns about nurturing propaganda and conspiracies for violent extremism. Through the systematic review of 82 peer-reviewed studies related to radicalization through social media published in scholarly journals, this paper evidence the growth of robust studies on the usage of social media for radicalization. Nonetheless, the current work hardly discusses the radicalization issues through social media and reveals an increasing trend of publication from 2017 with a major contribution from the USA, Germany, and England. The thematic analysis indicated determinants of radicalization and the mitigation measures for the deradicalization of content on social media. However, the knowledge gap persists to understand the effects of radicalization in the different regional settings and further framing of content specific to target populations. Individuals must have the critical social media literacy to counteract the rising radicalization through social media. Individual users’ political interests are key factors in their radicalization such as citizens losing faith in the government and political parties. Active rather than passive searchers of violent radical material are more likely to engage in political violence. The results indicate that further research using experimental design, grounded theory, and pilot interventions may be relevant to suggest a solution to mitigate radicalization on social media.
Potable Water Quality Prediction Using Artificial Intelligence and Machine Learning Algorithms for Better Sustainability
Authors: YURTSEVER Mustafa , EMEÇ Murat
Published: March 2023

Water is one of the most important resources for human life and health. Global climate change, industrialization and urbanization pose serious dangers to existing water resources. Water quality has traditionally been predicted by expensive, time-consuming laboratory and statistical analysis. However, machine learning algorithms can be applied to determine the water quality index in real time efficiently and quickly. With this motivation, a dataset obtained from the Kaggle website was used to classify water quality in this research. Some features were found to be empty in the data set. Traditional methods (drop, mean imputation) and regression method were applied for null values. After the null values were completed, RF, Adaboost and XGBoost were applied for binary classification. Gridsearch and Randomsearch methods have been applied in hyper parameter optimization. Among all the algorithms used, the SXH hybrid method created with the Support Vector Regression (SVR) and XGBoost methods showed the best classification performance with 99.4% accuracy and F1-score. Comparison of our results with previous similar studies showed that our SVR XGboost Hybrid (SXH) model had the best performance ratio (Accuracy, F1-score). The performance of our proposed model is proof that hybrid machine learning methods can provide an innovative perspective on potable water quality.
Approximate Solution of Sub diffusion Bio heat Transfer Equation
Authors: Sonawane Jagdish , Sontakke Bahusaheb , Takale Kalyanrao
Published: March 2023

In this paper, author’s study sub diffusion bio heat transfer model and developed explicit finite difference scheme for time fractional sub diffusion bio heat transfer equation by using caputo fabrizio fractional derivative. Also discussed conditional stability and convergence of developed scheme. Furthermore numerical solution of time fractional sub diffusion bio heat transfer equation is obtained and it is represented graphically by Python.
Cost-effectiveness of Syphilis Screening in Pregnant Women: A Literature System Review
Authors: Zhang Meng , Zhang Hongyan , Hui Xiaoqing , Qu Huiming , Xia Junfen , Xu Feng , Shi Cannan , He Junjian , Cao Yuan , Hu Mengcai
Published: March 2023

The cost-effectiveness study of syphilis screening in pregnant women has not been synthesized. The aim of this study is to synthesizes the economic evidence of the cost-effectiveness of syphilis screening in pregnant women which might contribute to make recommendations on future direction of syphilis screening approaches. We systematically search Medline, PubMed and Web of Science for relevant studies published before May 19th 2022 and identified cost-effectiveness analysis for syphilis screening in pregnant women. The methodological design quality was appraised by Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 checklist. Seventeen literature met the eligibility criteria for full review. Of the seventeen studies, four studies evaluated interventions using different screening methods, seven studies assessed the combination of syphilis test and treatment interventions, three studies focused on repeat screening intervention and four studies evaluated the intervention integrated syphilis and HIV test. The most cost-effective strategy appeared to be rapid syphilis tests with high treatment rate of the positive pregnant women. The cost-effectiveness of syphilis screening in pregnancy has been widely demonstrated. It is more important to improve the compliance of maternal screening and the treatment rate of positive pregnant women while implementing screening.
A Multi-Directional Analysis of the Center of Resistance using Finite Element Model of the Human Mandibular Canine
Authors: Kamali Elaheh , Geramy Amirreza , Geramy Allahyar
Published: March 2023

Background
The most important factor determining the quality of orthodontic tooth movement is the relationship between the force and the tooth center of resistance. Tooth supporting structures features affect the center of resistance location and these features varies in different areas around the specific tooth. So the aim of this study is the multi-planar analysis of the center of resistance using finite element models of the human mandibular canine to find the exact location of the center of resistance when viewed from different aspects.
Method
The left mandibular canine, periodontal ligament, cortical bone and spongy bone designed in Soidwork (version 2021) according to a contralateral canine with a complete eruption in a case with an impacted canine which has been ordered for CBCT. the tooth dimension was slightly modified according to wheelers dental anatomy. The meshed model was created. A 1N.mm couple was applied to the model and the center of resistance was evaluated from different 24 planes with 15 degrees intervals.
Results
The location of human mandibular center of resistance is different in horizontal plane when evaluated in different directions. It is in the range of 46–86% of canine root length from the apex and moves up to 4.48 millimeters occlusogingivally. In the buccal or lingual directions CRes location was found more apical than its mesial or distal counterparts.
Conclusions
the location of the CRes changes when evaluated in different directions related to supporting tissue features. It can therefore be concluded that canine requires a higher M/F for buccolingual translation than for a mesiodistal translation
Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS
Authors: Mora Santiago , Friis Rasmus von Huth , Stuckert Anna , Noes-Holt Gith , Montañana-Rosell Roser , Sørensen Andreas , Selvan Raghavendra , Allodi Ilary
Published: March 2023

Loss of connectivity between spinal V1 inhibitory interneurons and motor neurons is found early in disease in the SOD1G93A mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of a presynaptic organizer, increases motor neuron survival and ameliorates motor phenotype, demonstrating that interneurons can be a potential target to attenuate ALS symptoms.
Precessing jet nozzle connecting to a spinning black hole in M87
Authors: Cui Yuzhu , Hada Kazuhiro , Kawashima Tomohisa , Kino Motoki , Lin Weikang , Honma Mareki , Ro Hyunwook , Mizuno Yosuke , Yi Kunwoo , Yu Jintao , Park Jongho , Jiang Wu , Shen Zhi-Qiang , Kravchenko Evgeniya , Algaba Juan Carlos , Cheng Xiaopeng , Cho Ilje , Giovannini Gabriele , Giroletti Marcello , Jung Taehyun , Lu Ru-Sen , Niinuma Kotaro , Oh Junghwan , Ohsuga Ken , Sawada-Satoh Satoko , Sohn Bong Won , Takahashi Hiroyuki R. , Takamura Mieko , Tazaki Fumie , Trippe Sascha , Wajima Kiyoaki , Akiyama Kazunori , An Tao , Asada Keiichi , Buttaccio Salvo , Byun Do-Young , Cui Lang , Hagiwara Yoshiaki , Hirota Tomoya , Hodgson Jeffrey , Kawaguchi Noriyuki , Kim Jaeheon , Lee Sang-sung , Lee Jee Won , Lee Jeong Ae , Maccaferri Giuseppe , Melis Andrea , Melnikov Alexey , Migoni Carlo , Oh Se-Jin , Sugiyama Koichiro , Wang Xuezheng , Zhang Yingkang , Chen Zhong , Hwang Ju-Yeon , Jung Dong-Kyu , Kim Hyo-Ryoung , Kim Jeong-Sook , Kobayashi Hideyuki , Li Bin , Li Guanghui , Li Xiaofei , Liu Z.Y. , Liu Qinghui , Liu Xiang , Oh Chung-Sik , Oyama Tomoaki , Roh Duk-Gyoo , Wang Jinqing , Wang Na , Wang Shiqiang , Xia Bo , Yan Hao , Yeom Jae-Hwan , Yonekura Yoshinori , Yuan Jianping , Zhang Hua , Zhao Rongbin , Zhong Weiye
Published: March 2023

Powerful relativistic jets in active galactic nuclei (AGN) are believed to be originated from the accretion of material onto the supermassive black hole (SMBH)1. The nearby radio galaxy M87 is one of the best examples of this phenomenon, and the recent detection of a black-hole shadow with the Event Horizon Telescope provided compelling evidence for this paradigm2. However, whether the central SMBH in M87 has a spin or not, a fundamental parameter of a BH along with the mass, remains unconstrained by observations since the appearance of the photon ring is rather insensitive to the spin2-4. A clue to this challenge is to trace the long-term evolution of the innermost jet base where the central BH and accretion disk tightly regulate its flow dynamics. Here we report an extensive analysis of the morphological evolution of the M87 jet nozzle based on 170 high-resolution radio images spanning more than two decades. The ensemble of the data reveals a periodic (a period of 11 years) variation of the jet direction with a peak-to-peak amplitude of ~10 deg on the sky. A successful fit of a precession model to the data as well as general-relativistic magnetohydrodynamic simulations strongly supports the presence of a spinning BH in M87, inducing a Lense-Thirring precession of a misaligned accretion disk by the frame-dragging effect5. Our results suggest that jet precession with a spinning BH can commonly exist in other more distant AGN but had evaded detection due to the small magnitude and long period of position angle variation.
Totally endoscopic concomitant aortic and mitral valve surgery in junctional epidermolysis bullosa: a case report
Authors: Yoshida Kazufumi , Yoshida Soshi , Hori Yoshimasa , Hideki Tsubota , Mochizuki Ryosuke , Nagano Tohru , Koyama Tadaaki
Published: March 2023

Background
Junctional epidermolysis bullosa is a rare skin and mucosal disorder characterized by blister formation in response to minor trauma and extracutaneous manifestations. There have been no reports of cardiac surgery and prognostication in patients with epidermolysis bullosa due to skin and mucosal fragility.
Case presentation:
A 55-year-old man presented with congenital junctional epidermolysis bullosa, hypertension, and vasospastic angina. He complained of dyspnea on exertion, and transthoracic echocardiography revealed severe aortic valve regurgitation, moderate aortic valve stenosis (tricuspid valve), and severe mitral valve regurgitation. Considering that the skin condition in the right chest wall was relatively healthy, the right thoracotomy approach was preferred and totally endoscopic concomitant mitral valve repair and aortic valve replacement were performed using a sutureless bioprosthetic valve (Perceval™ (Corcym, Group, Milan, Italy)). Polyurethane and silicon dressing foams were used to protect the skin at the site of contact with the bag valve mask, arterial pressure catheter, intravenous catheter, and the tracheal intubation tube. Vertical mattress sutures were used for the skin sutures. The postoperative course was uneventful, and the patient was discharged nine days after the operation. There was no indication for reoperation until three years follow-up period.
Conclusions
The totally endoscopic concomitant aortic and mitral valve surgery using Perceval™ prosthesis can be performed safely in patients with junctional epidermolysis bullosa by adequate protection of the skin and mucosa.
Effectiveness of Frailty Intervention for Frail Older Patients during the Hospitalization
Authors: Wang Yu Chun , Liang Chih-Kuang , Chou Mei-Hsiang , Chiu Chun-Fang , Lin Hsiao-Chia , Hsu Ying-Hsin , Liao Mei-Chen , Yin Chun-Hao , Chou Ming-Yueh , Lin Yu-Te
Published: March 2023

Objectives: This study aims to assess the effectiveness of a multidomain intervention program on the change in functional status of hospitalized older adults.
Design: This single-arm, prospective, non-randomized interventional study investigates the efficacy of a multidomain interventional program including cognitive stimulation activity, simple exercises, frailty education, and nutrition counseling.
Setting and participants: At a tertiary hospital in southern Taiwan, 352 eligible patients were sequentially enrolled. Included patients were aged ≥65 years (mean age, 79.6 ± 9.0 years; 62% male), scored 3–7 on the Clinical Frailty Scale (CFS), and were hospitalized in the geriatric acute ward.
Intervention: Those receiving standard care (physical rehabilitation and nutrition counseling) during January–July 2019 composed the historical control group. Those receiving the multidomain intervention during August–December 2019 composed the intervention group.
Measurements: The primary outcome was the change in activities of daily life (ADL), as assessed using the Katz Index and a generalized estimating equation model. The length of hospital stay, medical costs, and re-admission rates were secondary outcomes.
Results: Participants undergoing intervention (n = 102; 27.9%) showed greater improvements in the ADL and CFS during hospitalization (ADL adjusted estimate, 0.61; 95% CI, 0.11–1.11; p = 0.02; CFS adjusted estimate, −1.11; 95% CI, −1.42– −0.80; p < 0.01), shorter length of hospital stay (adjusted estimate, −5.00; 95% CI, −7.99– −2.47; p < 0.01), lower medical costs (adjusted estimate, 0.58; 95% CI, 0.49–0.69; p < 0.01), and lower 30- and 90-day readmission rates (30-day adjusted OR [aOR], 0.12; 95% CI, 0.27–0.50; p < 0.01; 60-day aOR, 0.04; 95% CI, 0.01–0.33; p < 0.01) than did controls.
Conclusions: Participation in the multidomain intervention program during hospitalization improved the functional status and decreased the hospital stay length, medical costs, and readmission rates of frail older people.
Socioecological and dietary change from 2001 to 2015 in rural West Java, Indonesia
Authors: Sekiyama Makiko , Tsuchiya Kazuaki , Roosita Katrin , Matsuda Hirotaka
Published: March 2023

This study assessed changes in the sociodemographic structure, land use, diet and nutritional status of the population of a rural village in West Java, Indonesia between 2000–2001 and 2015–2017. This was a period of rapid socioeconomic change in the country. Over this period, the village’s population increased by 50%. The growing population was largely engaged in non-agricultural employment within the village or in nearby cities, and the village maintained its function as a farming village without major changes in the local land use or ecosystem. In 2000, the diet, nutritional intake and health status of the villagers were fairly uniform. Indicators based on BMI, for example, classified 98% of target children and 70% of target mothers as ‘normal’, regardless of household economic status. However, by 2015, more people worked outside the village and dependence on a market economy had increased. Dependence on food from outside the village, such as processed foods that are cheap and easy to obtain and store, had also increased. Foods such as cassava, taro, and sweet potatoes, which were grown and consumed in 2000, were not consumed in 2015. The amount of beans, nuts, and vegetables consumed had also decreased. Additionally, the use and sharing of natural resources and the accompanying knowledge transfer had been gradually lost. As a result, variation in diet, nutritional intake, and health conditions within the village significantly increased over time, and overnutrition and undernutrition coexisted by 2015.
Comparison of Central Venous Catheter Thoracic Drainage with Traditional Closed Thoracic Drainage after Minimally Invasive Surgery for Esophageal Cancer: A Retrospective Study
Authors: Zhao Yang , Ma Yue , Bai xia , Wang Tao , Song Dong , Li Tao
Published: March 2023

Background
To compare the effectiveness and safety of central venous catheter thoracic drainage (CVC-TD) with traditional closed thoracic drainage (TCTD) after minimally invasive surgery for esophageal cancer.
Methods
We conducted a retrospective study of 103 patients who underwent minimally invasive surgery for esophageal cancer at our institution between January 2017 and December 2019. Forty-four patients received CVC-TD, while 59 patients received TCTD. We compared the following outcomes between the two groups: drainage volume, drainage duration, incidence of postoperative complications (including pleural effusion, pneumonia, and atelectasis), length of hospital stays, and overall survival.
Results
The drainage volume and duration were similar between the two groups. However, the incidence of postoperative complications was significantly lower in the CVC-TD group than in the TCTD group (p < 0.05). The length of hospital stay was also shorter in the CVC-TD group (p < 0.05). There was no significant difference in overall survival between the two groups.
Conclusion
CVC-TD is a safe and effective alternative to TCTD after minimally invasive surgery for esophageal cancer. It may help reduce the incidence of postoperative complications and shorten the length of hospital stay. Further studies are needed to confirm these findings.
Subfossil chironomid assemblages as indicators of remedial efficacy in the historically contaminated St. Lawrence River at Cornwall, Ontario
Authors: Armstrong Isaac , Moir Katherine , Ridal Jeffrey , Cumming Brian
Published: March 2023

Long-term data are required to quantify the impacts of historic industrial pollution and subsequent remedial action on the nearshore benthic community in the St. Lawrence River Area of Concern at Cornwall, Ontario. Specifically, high-quality temporal records are needed to understand changes in benthic invertebrate assemblages in response to multiple possible drivers including industrial pollution, environmental heterogeneity, and climate warming. We compare long-term records of subfossil chironomid assemblages and geochemical variables among sediment cores from two Cornwall sites with differing pollution histories and a minimally disturbed downstream reference site. Chironomids were functionally absent from the Cornwall sediment cores when mercury and zinc concentrations were elevated. As metal concentrations decreased in more recent sediment intervals, chironomid abundance and the relative abundance of pollution-sensitive taxa increased. Recently deposited sediment in all three sediment cores display increased relative abundance of warm-water, macrophyte-associated taxa. We conclude that these temporal changes in chironomid assemblages provide evidence for ecological recovery for both of the impacted sites, consistent with the objectives of the current management strategy. These findings advance our understanding of industrial impacts on fluvial chironomid ecology, directly inform local management strategies, and further develop the application of chironomids as bioindicators for contaminated sediments.
Ground Joinability and Connectedness in the Superposition Calculus
Authors: Duarte André , Korovin Konstantin
Published: March 2023

Problems in many theories axiomatised by unit equalities (UEQ), such as groups, loops, lattices, and other algebraic structures, are notoriously difficult for automated theorem provers to solve. Consequently, there has been considerable effort over decades in developing techniques to handle these theories, notably in the context of Knuth-Bendix completion and derivatives. The superposition calculus is a generalisation of completion to full first-order logic; however it does not carry over all the refinements that were developed for it, and is therefore not a strict generalisation. This means that (i) as of today, even state of the art provers for first-order logic based on the superposition calculus, while more general, are outperformed in UEQ by provers based on completion, and (ii) the sophisticated techniques developed for completion are not available in any problem which is not in UEQ. %In particular, this includes key simplifications such as ground joinability, which have been known for more than 30 years. In fact, all previous completeness proofs for ground joinability rely on proof orderings and proof reductions, which are not easily extensible to general clauses together with redundancy elimination. In this paper we address this limitation and extend superposition with ground joinability, and show that under an adapted notion of redundancy, simplifications based on ground joinability preserve completeness. Another recently explored simplification in completion is connectedness. We extend this notion to ``ground connectedness'' and show superposition is complete with both connectedness and ground connectedness. %We implemented ground joinability and connectedness in a theorem prover, iProver, the former using a novel algorithm which we also present in this paper, and evaluated over the TPTP library with encouraging results.
An integrated AHP-PROMETHEE II ranking method to evaluate the resilience of sewer networks considering urban flood and ground collapse risks
Authors: Zhang Chuanli , Kwon Soonwon , Oh Jeill , Park Kyoohong
Published: March 2023

The aim of this study is to present criteria to evaluate the resilience of sewer networks related to ground collapse and urban flooding likely to occur in a specific region and then to determine the ranks of the sewer networks resilience of the selected regions to show the applicability of the analytic hierarchy process (AHP) and the Preference Ranking Organization Method for Enriching Evaluations (PROMETHEE II) method. Fourteen evaluation criteria representing resistance, reliability, redundancy, and response and recovery are presented and their weights are estimated by the AHP by asking questionnaires to 10 sewer experts, leading to the result that the sub-criteria of reliability showed the highest importance, followed by the length ratio of good pipelines (under resistance) and adequacy of the flow capacity of the bypass pipelines (under redundancy). Four separate small blocks of drainage areas (total area of 3.57 km2; sewer length of 50.6 km) in Seoul are chosen for the case study. Using appropriate preference functions and thresholds for each evaluation criterion for PROMETHEE II application yields the resilience rankings of four blocks as Block III > Block IV > Block I > Block II. A sensitivity analysis was also carried out by changing the weights.
Исследование изменений карьерных ориентаций у студентов психологического направления
Authors: Морозова Анастасия С. , Найденова Елизавета В.
Published: March 2023

В статье рассмотрена динамика формирования карьерных ориентаций у студентов психологического направления. Актуальность исследования объясняется важностью понимания особенностей профессиональной направленности будущих профессионалов. Понимание и сознание собственных якорей карьеры важно для любой личности, желающей построить успешную и комфортную карьеру. Обобщенное  рассмотрение системы ценностей в профессиональном плане позволяет составить общий портрет будущего специалиста, что позволит работодателям создавать оптимальные условия для успешного найма сотрудников. Новизна работы заключается в проведении лонгитюдного исследования якорей карьеры на одной и той же группе на протяжение 3 лет, что позволяет делать более объективные выводы о изменения карьерных предпочтений, нежели чем при проведении исследования на разных группах. Во Введении автором обозревается актуальность исследования, а также основные теоретические подходы, обозревающие такой феномен как «Якоря карьеры». Для исследования проводилось анкетирование группы студентов психологического направления из 20 человек на первом, втором и третьем курсе обучения. В разделе «Методы» представлены основные способы анализа теоретических и эмпирических данных. Результаты исследования показывают наличие значимых различий между данными, полученными на первом и втором курсе, обнаружены изменения в определение приоритетных якорей карьеры среди группы на каждом году обучения. В разделе «Обсуждение результатов» автор отмечает, что несформированность и малая дифференцированность карьерных ориентаций в целом характерна для студентов психологов, в особенности на первом курсе из-за отсутствия необходимого опыта и знаний, наличия мифов и обыденных установок относительно будущей профессиональной деятельности. Также отмечено, что в процессе обучения так или иначе будет формироваться разочарование относительно некоторых особенностей будущей карьеры, в связи с чем также меняются профессиональные предпочтения.
Влияние просмотра разговорных видео психологов в социальной сети «TikTok» на мотивацию и вовлеченность студентов-психологов в изучение профессии
Authors: Старыгина Влада Р.
Published: March 2023

Во введении автор раскрывает актуальность исследования современных медиа как образовательного ресурса. Современные социальные сети, в особенности «TikTok» зачастую воспринимаются как исключительно развлекательные. Однако, в последние годы возникла тенденция публикации в «TikTok» различного обучающего контента, который может способствовать вовлечению молодых людей в интересующие их области. В разделе «Методы» приводятся используемые автором инструменты и методики сбора данных. Были применены: анкетирование участников исследования с помощью авторской методики и тестирование студентов с помощью методики А.А. Реана «Методика диагностики позитивной (надежда на успех) и негативной (боязнь неудачи) мотивации». Также автором был использован метод математической обработки данных результатов экспериментального исследования. В качестве эмпирического объекта исследования выступали студенты-психологи (60 человек), преимущественно возраста 19 лет. В разделе «Результаты» говорится о том, что из всех опрошенных на вопрос об использовании социальной сети TikTok вариант «Да, использую» выбрало большинство человек, что составило 70,7 % от общего числа респондентов. Основной вопрос, считают ли участники опроса данный вид контента полезным в повышении мотивации к изучению психологии показал, что большая часть респондентов согласны или скорее согласны, чем не согласны (92,7 %).  В обсуждении результатов приводятся исследования других авторов, изучающих данную проблему. В заключении приводятся итоги проведённого исследования. Таким образом, путем авторского опроса было выявлено, что социальная сеть TikTok оказывает положительное влияние на вовлеченность в изучении психологии. 59,5 % опрошенных. Результаты показали, что 88,1 % считают данный вид контента способным повысить заинтересованность (вовлеченность) в изучении психологии.
Structure-Function Relationship of Homogentisate 1,2-dioxygenase:
Understanding the Genotype-Phenotype Correlations in the Rare Genetic
Disease Alkaptonuria
Authors: Bernini Andrea , Spiga Ottavia , Santucci Annalisa
Published: March 2023

Alkaptonuria (AKU), a rare genetic disorder, is characterized by the accumulation of homogentisic
acid (HGA) in organs, which occurs because the homogentisate 1,2-dioxygenase (HGD) enzyme
is not functional due to gene variants. Over time, HGA oxidation and accumulation cause the
formation of the ochronotic pigment, a deposit that provokes tissue degeneration and organ malfunction.
Here, we report a comprehensive review of the variants so far reported, the structural studies on
the molecular consequences of protein stability and interaction, and molecular simulations for pharmacological
chaperones as protein rescuers. Moreover, evidence accumulated so far in alkaptonuria research
will be re-proposed as the bases for a precision medicine approach in a rare disease.
Understanding marketing strategy and value creation in the era of business competition
Authors: Sintani Lelo , Ridwan Ridwan , Kadeni Kadeni , Savitri Savitri , Ahsan Muhamad
Published: March 2023

This study discusses marketing understanding and strategy as well as value creation in business in an era full of competition. To discuss this study, we get support from various publications about marketing and new strategies and products so that a company can compete and make it one of the companies that can survive in an era where competition is—obtaining data through a google school search on literature which is scientific evidence of how business marketing currently has a strategy and creates new value for businesses to compete. After the data is collected, we analyze it under a phenomenological approach, an attempt to get data evidence to answer phenomenal problems on the validity and reliability of findings. Where the business is very competitive, of course, the strategy has one concept and can create value in marketing by following various trends that will occur in the following year; likewise, the marketing strategy has components and planning that follow the characteristics of the business being carried out with of course having a budget that sufficient so that the business can compete as expected.
EdTech and the Saudi EFL learners: Bane or boon?
Authors: Aljafen Bandar Saleh
Published: March 2023

Educational technology in the English as a Foreign Language (EFL) classroom has great potential to usher in innovativeness and authenticity in the language instruction and learning processes apart from facilitating collaboration, cooperation, and engagement.  Consequently instruction can take newer pathways that ensure these qualities along with enhancing learners’ language skills. Data on the application of edtech tools were gathered from 60 undergraduate EFL learners and four teachers at Qassim University, Saudi Arabia. The free version of Grammarly was found to be the one most accessed by the participants for grammar and language enrichment in academic writing assignments, followed by Writer, Scribens, and Ginger, in that order. Teachers, on the other hand, were apprehensive of learners’ dependence on apps and perceived these as hurdles in their learning as they got corrected and improved versions of their writing but without detailed explanations which encouraged a tendency in the learners to rely on these free apps.
Fundamental research on Japanese language education and career path connectivity in ASEAN countries
Authors: Niimi Tatsuya
Published: March 2023

Although Japan is a major powerhouse, it is experiencing issues with a low birth rate and ageing population. The impact of these issues on the workforce could be significant. There are other ASEAN countries that are still considered developing nations and there is potential that Japan
could bolster its workforce by employing students and workers from these countries. For this to be feasible, these individuals would need to be good Japanese language speakers. Associate Professor Tatsuya Niimi and his team at the Faculty of Economics, Nagoya Gakuin University, Japan, are
conducting fundamental research on Japanese language education and career path connectivity in ASEAN countries. The researchers are seeking to understand how to improve teaching programmes that are geared towards resolving the shortage of local higher educated human resources for Japanese
firms, especially small-to-medium enterprises. They want to establish exactly how Japanese language teachers can ensure that their lessons are adequate and what Japanese firms require of their employees in order to make language students an adequate fit. The research involves using computing
technology to conduct remote interviews, web questionnaires and analyses. It will ascertain the requirements of Japanese business and then use this information to inform how students in ASEAN countries learn the Japanese language.
Development research of arithmetic and mathematics curriculum incorporating revolutionary and cumulative knowledge growth
Authors: Ikeda Toshikazu
Published: March 2023

The continuous development of education is important in order to ensure it keeps growing and improving. Professor Toshikazu Ikeda, College of Education, Yokohama National University, Japan, is a Professor of Mathematics who is a proponent of revolutionary knowledge growth through overturning,
expanding, and integrating acquired knowledge and skills. This is about progression through bridging the gap between a knowledge goal and the existing knowledge base through developing techniques and pathways to that goal. Ikeda believes that by inserting revolutionary knowledge growth into
the mathematics curriculum in Japan, children can be encouraged towards more independent and problem solving based thinking. He has performed an analysis of current teaching materials which involved examining local teaching materials in a specific area, using lessons to analyse and evaluate
those materials and looking at long-term global teaching materials that give a deeper examination of specific topics, focusing on how and where it can be used and how students react to the content. In his work, Ikeda uses modelling as a problem solving tool and to develop techniques to deepen
learning and lead to revolutionary knowledge growth. Ikeda is collaborating with Professor Max Stephens, Melbourne University, to produce lectures centred on revolutionary growth knowledge for students at teacher training colleges. A key part of Ikeda's work is teaching mathematical modelling
in order to help students understand the importance of mathematics and develop their abilities.
Overview of retailers' merchandising and innovation strategy
Authors: Kim Changju
Published: March 2023

Boundary spanning involves linking internal networks with external sources of information. Professor Changju Kim, College of Business Administration, Ritsumeikan University, Japan, is among researchers investigating the role of boundary spanners and is doing so within a new field of
retail company research. He and his team are conducting various strands of research focused on continuous improvement theory in the field of management. This concerns management issues, such as employee motivation and training, and how these improvements interact with organisational design
inside and outside of the company. The studies can then be linked to the qualitative and quantitative results of the company. Kim's research applies the theory of continuous improvement and research results in the field of organisation to retail company research, with a view to solving the
problem of buyer management in innovative purchasing activities. Important to this research is associating buyers' purchasing behaviour, inter-firm relationships and internal organisations in issues of purchasing strategies in retail companies in recent years. Kim hopes the work will contribute
to the theoretical development of conventional retail company research and channel research. In recent work, the team has been exploring how marketing enables firms to continually create innovative customer value, which includes looking at how creative marketing accelerates a company's growth
engine.
Research on the teaching of classes on probability distributions and hypothesis testing in high school mathematics departments and universities
Authors: Matsumoto Chieko
Published: March 2023

Data is a prevalent concept in today's world. We are in an era of Big Data and the field of data science is possibly more important than it ever has been. Associate Professor Chieko Matsumoto, School of Education, University of Fukui, Japan, is an expert in data science who is conducting
research on statistics and data science education in upper secondary schools and universities, with a focus on the concept of statistical hypothesis testing. Matsumoto's goal is to quantify what is lacking in the current mathematics curriculum in order to put forward recommendations to overcome
challenges facing statistics and data science education. She and her team want to develop teaching materials and practical guidance on statistics and data science education. Their research approach and methods are developed with a focus on probability distributions and hypothesis testing.
The researchers will conduct a questionnaire survey of upper secondary school teachers to clarify the various teaching problems and teaching difficulties that teachers encounter when teaching statistical hypothesis testing. The team is yet to obtain permission to conduct a large-scale questionnaire
and so the researchers have been conducting small-scale interviews to establish an understanding of teaching difficulties faced by upper secondary school teachers.