bluuebunny/crossref_metadata_2025 huggingface dataset:
Importancia de los parámetros clínicos analíticos de la sepsis grave en la uropatía obstructiva
Authors: Bedate Núñez María , Moreno Racionero Francisca , De Andrés Asenjo Beatriz , Legido Morán Ana Patricia , Rabadán Jimenez José Máximo , Bermejo Martín Jesús Francisco , Calleja Escudero Jesús
Published: September 2023

INTRODUCCIÓN: La uropatía obstructiva (UO) es muy prevalente. Su nivel de bacteriemia es elevado complicándose hasta en el 40% de los casos con una sepsis grave. OBJETIVO: Describir el perfil clínico del paciente con UO del HCU de Valladolid.

MATERIAL Y MÉTODOS: Se diseña un estudio observacional y descriptivo prospectivo. Se incluyó a todo paciente mayor de edad ingresado con carácter de urgencia con el diagnóstico de UO. Los pacientes fueron clasificados en dos grupos en función de si desarrollando sepsis grave (SG) o no (NSG). Se realizó un análisis estadístico descriptivo e inferencial considerándose una p < 0,05 como significativa.  Las variables cuantitativas se expresaron en rango intercuartílico y medianas y las cualitativas en porcentajes y números absolutos.

Los datos demográficos y clínicos se analizaron mediante el test Chi - cuadrado de Pearson (Ӽ2) para las variables categóricas, y para las variables continuas el test U - Mann - Whitney.

RESULTADOS: Nuestra serie consta de 65 pacientes. La UO ocurrió preferentemente en varones (63,07%). La HTA y la obesidad fueron las comorbilidades más frecuentes. La mayoría de la UO eran incompletas y secundarias a litiasis. El 64,61% desarrolló una SG. El Cultivo de orina fue positivo en el 20,63% de los casos siendo el microorganismo más frecuente la E. coli. En el 40% de los pacientes se realizó una derivación urinaria urgente.

CONCLUSIÓN:

Existe un perfil analítico característico de SG mantenido en el tiempo que consiste en la elevación en sangre del porcentaje de neutrófilos, de procalcitonina y disminución de bicarbonato.
Historia de los trasplantes
Authors: Vaquero Puerta Carlos , García-Rivera E , Fernández Bello S
Published: September 2023

Los trasplantes constituyen un conjunto de técnicas quirúrgicas caracterizadas por sustituir órganos dañados por otros nuevos y sanos. Hay referencias históricas, desde los primeros tiempos de la humanidad en donde se recogen recambios de órganos, vísceras o partes del cuerpo e incluso la combinación de partes del cuerpo de diferentes especies animales que recuerdan la sustitución terapéutica del trasplante. Existen referencias en la mitología, a nivel de leyendas, en la descripción de hechos milagrosos, existiendo no obstante datos más científicos concernientes a diversos intentos de este tipo de sustituciones. Hay aportaciones puntuales sobre los trasplantes, intentos realizados en experimentación animal y por otra parte hitos históricos que han hecho posible que este tipo de técnicas puedan ser consideradas de rutina en la práctica quirúrgica habitual. Se realiza un recorrido histórico en el trabajo, analizando estas aportaciones.
Goya, un hombre libre, Real Academia de Medicina y Cirugía de Valladolid para la Reunión de las tres Reales Academias de Valladolid. 16 de mayo de 2019.
Authors: Gil-Carcedo Luis María
Published: September 2023

Goya se caracteriza por su aprecio por la libertad, fue ante todo un hombre libre. El subtítulo de la conferencia “Cuadros para una exposición” es oportuno, pues el corpus de nuestro parlamento acoge comentarios personales acerca de los distintos asuntos sobre los que Goya plasmó sus lienzos. Se analizan sus obras sobre mujeres, niños y familias. Goya es el primer reportero de guerra, se tratan sus óleos sobre la contienda contra los franceses y los grabados acerca de “Los Desastres de la Guerra”. Se pone de manifiesto la postura de Goya ante la tauromaquia negando la posibilidad de que el pintor fuera un primer antitaurino.
Discurso de recepción del Académico Corresponsal Dr.Pascual González Masegosa, Real Academia de Medicina y Cirugía de Valladolid, 18 de mayo de 2019.
Authors: Mateo Gutiérrez Antonio María
Published: September 2023

Excmo. Sr. Presidente; Ilmos. Sres. Académicos; Ilmo. Sr. Jefe Territorial de Cultura de Valladolid; Autoridades    Sanitarias, Alcaldes de localidades con tradición taurina de la provincia; Distinguidos colegas, Señoras y Señores:

 

Pere Sánchez Ferré en su Novela “El Caballero del Oro Fino: Cábalas y Alquimia en el Quijote” narra el momento en el que el protagonista, el tal Caballero dorado, invita a Sancho, Gobernador de la Ínsula Barataria, a ocupar un puesto destacado en su salón y le dice: “quiero que aquí, a mi lado y en compañía de estas buenas gentes te sientes…”.

Dr. González Masegosa, Gobernador de la Ínsula en la que habitan los Cirujanos taurinos españoles, tome asiento aquí, a nuestro lado, en compañía de estas buenas gentes que han disfrutado con su discurso y que ahora habrán de soportar pacientemente el mío.
Amigos o enemigos. Murciélagos en el origen y emergencia de zoonosis, con referencia particular a la rabia
Authors: Rodríguez Ferris Elias F.
Published: September 2023

Los murciélagos forman uno de los órdenes (orden Chiroptera) con mayor número de especies, solo superados por los roedores (orden Rodentia). A sus características singulares de capacidad de vuelo, nocturnos, ecolocación o hábitos alimentarios diversos (insectos, pequeños animales, fruta o sangre) unen otras, como su longevidad y la condición de reservorios asintomáticos de patógenos humanos, especialmente de virus ARN, que han sido la causa de graves epidemias. En ellas el virus en cuestión permanece en un estado persistente resultado de la coincidencia de una modulación de las defensas antivirales propias, control de la inflamación y de la respuesta inmunitaria, en un equilibrio, que cuando se altera, propician condiciones favorables al salto de la barrera de especie y la emergencia de zoonosis. En la rabia, producida por de Lyssavirus, 16 de las 18 especies descritas hasta la fecha (2 pendientes de aceptación) han sido aisladas de murciélagos, ahora agrupadas en 3 Filogrupos. De muchas de éstas se han derivado saltos de especie y casos humanos letales. El interés de los murciélagos es creciente respecto de la rabia y en Europa ya se han descrito 5 especies de Lyssavirus de este origen, en particular los denominados EBLV-1 y EBLV-2, que han producido casos humanos y despertado un gran interés por la vigilancia. Suma, además, que las vacunas humanas disponibles, elaboradas con cepas derivadas de la especie clásica RABV, no son eficaces más que en el Filogrupo 1 de pertenencia. Todas las administraciones han preparado planes de contingencia y guías de uso con recomendaciones.
PEMAHAMAN KESUKUAN DALAM KELUARGA MULTI-SUKU DI PONTIANAK
Authors: Wahyuni Indah Sri
Published: September 2023

In general, this research is motivated by the problem of the condition of knowledge in one of the multi-ethnic families in the komplek BLKI, Pontianak Tenggara, who still do not fully know about the ethnic they belong to. This was revealed after observing daily habits that do not describe the ethnic group used as the identity. The purpose of this study is to find out about: (1) The application of culture to multi-ethnic families in everyday life. (2) Knowledge of each member of a multi-ethnic family about the tribe they belong to. (3) General material about ethnic groups belonging to multi-ethnic families. (4) Factors influencing ethnic knowledge in multi-ethnic families. This research used qualitative methods in the form of observation and online interview. The data source for this research is one of the multi-ethnic families who live in the komplek BLKI, Pontianak Tenggara. As a result, the condition of ethnic knowledge in the family is not good. The discussion is that family members apply some of the tribal culture in everyday life, knowledge about the ethnicity that is owned is not much, the tribes that are owned are Malay and Bugis, the factors that influence knowledge in the multi-ethnic family are individual factors, heredity, and environmental factors. It can be concluded that the condition of ethnic knowledge in multi-ethnic families in the komplek BLKI, Pontianak Tenggara is still limited.
DA’WAH, RELIGIOUS ACTIVISM AND DIGITAL ARENA: THE EXPERIENCES OF STUDENT ACTIVIST’S IN UNIVERSITAS NEGERI MALANG, INDONESIA
Authors: Thoriquttyas Titis , Ahsin Nurul , Khasbulloh M Nabil
Published: September 2023

The dynamic of da’wah among students have special characteristics in packaging da’wah content, selection of da'i and contextual trends in it. In addition, student figures of da’wah activists are representations of urban Muslims who are closely related to religious symbols, especially in the digital arena. Da’wah and religious activism in the digital arena, especially within the scope of urban youth, are the core topics of this research. This study took a sample on the Instagram posts of UKM BDM al Hikmah Universitas Negeri Malang by focusing on the da’wah narratives used. Through Bourdieu's habitus theory, Weber's theory of religious authority and visual semiotics, virtual da’wah narratives and the existence of da'i chosen by BDM al Hikmah, UM and the selection of da’wah content are two important problem formulations in this research. The findings of this study provide an overview of the position of preachers in the digital space having at least three capitals, namely social, charisma and rational. Meanwhile, in the visual semiotics review, the choice of language and discussion of da’wah that is carried out is more in accordance with the contexts and contemporary problems faced by listeners, there has been a dynamic negotiation process between the da’i and the listener
Apalutamide as a therapeutic option in case of local failure in the nmCRPC
Authors: Stankiewicz Magdalena
Published: September 2023

Apalutamide is a non-steroidal selective androgen receptor inhibitor approved for the treatment of high-risk non-metastatic castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer. The paper describes a case of a patient diagnosed with prostate cancer with a long-term course of the disease. The patient was diagnosed with a non-metastatic castration-resistant stage 18 years after primary treatment. Systemic treatment with apalutamide was recommended. Initially, the treatment was carried out as part of the extended access to apalutamide program and from March 2022 as part of the B.56 drug program. The study presents the effectiveness and safety of the therapy in a 12-month follow-up period and discusses controversial aspects of the patient's previous treatments.
Plasma cell myeloma as one of the causes of bone pain in family medicine
Authors: Kade Grzegorz , Michalak Maciej , Kade Bartosz , Spaleniak Sebastian , Podgórska Agnieszka , Hałka Janusz
Published: September 2023

The article draws attention to the need to maintain oncological vigilance in the daily practice of a family doctor. Diagnosis and effective treatment of hypercalcemia and plasma cell myeloma are presented.
Apalutamide treatment of locally advanced prostate cancer
Authors: Palasik Maria
Published: September 2023

Prostate cancer is most commonly diagnosed cancer in men. The choice of treatment method depends on many factors: the patient’s age, other patient’s diseases, psychophysical status and expected survival time. Hormonotherapy plays very important role in patients with no possible radical treatment. New therapies apply in patients with castration-resistant metastatic prostate cancer. First registered drug in patients with biochemical progression without metastases is apalutamide.
Composite effect of adaptation to climate variability, agrometeorological information, and socioeconomic and institutional factors on agricultural productivity in Kenya
Authors: Atsiaya Godfrey Obwina , Obedy Gido Eric , Waluse Sibiko Kenneth , Jabu Mbudzya Joseph
Published: September 2023

Climate variability has adversely affected agriculture and adaptation strategies are significant in enhancing resilience hence ensuring food security. Agrometeorological services are essential in decision-making and developing farmers’ specific adaptive capacities mainly when variability affect agricultural productivity. This study focuses on the composite effect of adaptation to climate variability, agrometeorological information, socioeconomic and institutional factors on agricultural productivity in Kenya. Multi-stage sampling technique was used to obtain a sample size of 384 sorghum farmers. The study used an endogenous switching regression model to control for the selection problem arising from adaptation to climate variability on agricultural productivity. Results indicate that extension contacts and education level were positively significant among adapters of climate variability. Additionally, the proportion of income allocated for farming was positively significant among non-adapters. On the other hand, access to credit, gender and age of decision makers were negatively significant among adapters of climate variability. Similarly, age was negatively significant among non-adapters of climate variability. Overall, adapters to climate variability had higher sorghum output than non-adapters. This study recommends that policymakers and other key stakeholders could increase the number of extension contacts and promote education to farmers so that they can access agrometeorological information, hence adaptation to climate variability.
Variation in knowledge, attitude, and practices toward antibiotic use among diplomates of the American Veterinary Dental College: a survey-based study
Authors: Montebello Jennifer A. , Granick Jennifer L. , Bollig Emma R. , Goldschmidt Stephanie L.
Published: September 2023

OBJECTIVE

To evaluate the knowledge, attitudes, and practices toward antibiotic use among board-certified veterinary dentists.

SAMPLE

104 veterinarians board certified by the American Veterinary Dental College.

METHODS

A 30-question survey was generated from an online platform and sent via email listserv to board-certified veterinary dentists. Responses were examined to identify patterns or correlations among the variables of interest.

RESULTS

There were 104 board-certified veterinary dentists who responded. The majority reported using prophylactic intraoperative antibiotics sparingly for dental procedures and predominately for patients with historic endocarditis or on immunosuppressive doses of steroids. For healthy patients, they reported that antibiotics are often prescribed during jaw fracture repair, maxillectomy/mandibulectomy, and treatment of stage 4 periodontal disease or periapical lucencies. Knowledge of antibiotic resistance and evidence-based antibiotic use were not significantly different between different practice sectors (academia vs private practice) or dependent on the duration of board certification. Dentists who did not believe antibiotics used postoperatively reduce local postoperative infection rates were less likely to prescribe injectable intraoperative antibiotics for the prevention of postoperative infection. No other variables were associated with the likelihood of prescribing intraoperative antibiotics. More than 95% of veterinary dentists surveyed agreed that specific antibiotic use guidelines for veterinary dentistry would help reduce inappropriate use of antibiotics.

CLINICAL RELEVANCE

There are differences among veterinary dentists regarding which procedures and patient-specific comorbidities they believe necessitate the use of prophylactic antibiotics. The development of a consensus statement and prospective studies of current antibiotic use are important next steps to improving antibiotic stewardship in veterinary dentistry.
Presence of Perfluoroalkyl Carboxylic Acids and Sulfonates in Vietnamese Food Contact Materials
Authors: Minh Phan Dang , Anh Hoang Quoc , Lieu Tran Thi , Quang Phan Dinh , Nghia Nguyen Trong , Chuc Nguyen Thi , Huong Nguyen Thi Anh , Tuyen Le Huu , Thi Quynh Hoa Nguyen
Published: September 2023

Per- and polyfluoroalkyl substances (PFASs) are considered as persistent organic pollutants (POPs), which should be restricted or eliminated. In this study, concentrations of four perfluoroalkyl carboxylic acids (perfluorobutanoic acid PFBA, perfluorohexanoic acid PFHxA, perfluorooctanoic acid PFOA, perfluorodecanoic acid PFDA) and four perfluoroalkyl sulfonates (perfluorobutane sulfonate PFBS, perfluorohexane sulfonate PFHxS, perfluorooctane sulfonate PFOS, perfluorodecane sulfonate PFDS) were analyzed in food contact materials (FCM) collected from Hanoi, Vietnam. A total of 15 FCM samples was obtained including several categories such as instant drink/food boxes, bags, cups, wrappers, and tray. The FCM samples were untrasonic extracted with methanol, concentrated, and filtered before analysis by a liquid chromatography–tandem mass spectrometry (LC-MS/MS) system. Recoveries of native and surrogate standards ranged from 70% to 130% with RSD < 20% in replicated analysis. Method detection limits of PFASs ranged from 0.04 to 0.08 ng/g. Concentrations of S8PFASs ranged from not detected (ND) to 1.46 (average ± SD: 0.417 ± 0.479) ng/g. Detection frequencies of PFASs decreased in the order: PFDA (33%) > PFBA, PFOA, PFHxS, PFOS (27%) > PFDS (13%) > PFHxA (7%) > PFBS (0%). Average concentrations of individual compounds decreased in the order: PFOS > PFDA > PFHxS > PFOA > PFBA > PFHxA > PFDS > PFBS. Relatively low PFAS concentrations found in the FCM samples of this study indicated that these substances were mainly derived from unintentional sources rather than intentionally added to the materials.
Desarrollo de mezclas para impresión 3d basadas en cemento portland y adiciones de metacaolín, micro sílice y carbonato
Authors: Robayo Salazar Rafael , Muñoz Miguel A. , Mejía de Gutiérrez Ruby
Published: September 2023

Este artículo se enfoca en la utilización de adiciones tipo microsílice (MS), metacaolín (MK) y carbonato de calcio (CaCO3) para el diseño de tintas cementicias basadas en cemento Portland ordinario (OPC) aptas para impresión 3D (manufactura aditiva). Las adiciones fueron incorporadas en las mezclas como sustitución del OPC en cantidades del 5-10% (MS), 5-15% (MK) y 5-15% (CaCO3). Se evaluó el efecto de las adiciones sobre las propiedades en estado fresco y endurecido de las mezclas tales como capacidad de extrusión, trabajabilidad (minislump), fluidez (mesa de flujo), tiempo de fraguado, tiempo abierto (open time) y capacidad de impresión. Adicionalmente, se realizó una inspección microscópica de las tintas de impresión mediante la técnica de microscopía electrónica de barrido (MEB) y se llevó a cabo la caracterización físico-mecánica mediante ensayos de densidad, absorción, porosidad y resistencia a la flexión y compresión. Los resultados demostraron que las adiciones influyen directamente sobre las propiedades anteriormente mencionadas. Se concluyó que las mezclas 90%OPC-5%MS-5%CaCO3 (mezcla 1) y 90%OPC-5%MS-5%MK (mezcla 2) exhibieron el conjunto de características más idóneas para ser implementadas como tintas de impresión 3D. A partir de estas mezclas fue posible la impresión 3D de probetas tipo viga (160 x 40 x 40 mm), logrando valores de resistencia la flexión a los 28 días de 3.4 MPa (mezcla 1) y 4.0 MPa (mezcla 2), y de resistencia a la compresión de 44 MPa (mezcla 1) y 50 MPa (mezcla 2). Estos resultados se consideran un punto de partida para futuras investigaciones, relacionadas con el uso de este tipo de adiciones en la impresión 3D de tintas cementicias basadas en OPC.
Atuação do psiquiatra clínico na perícia médica do INSS
Authors: Almeida Alberto Carvalho de , Souza Juberty Antonio de
Published: September 2023

O impacto das doenças mentais abrange também o ambiente de trabalho. Os transtornos mentais já ocupam o terceiro lugar em termos de afastamento de trabalho, atrás apenas das doenças coronárias e das lesões osteomusculares. Entre as doenças mais incapacitantes para o trabalho, estão a depressão, a esquizofrenia, o transtorno afetivo bipolar, o alcoolismo e o transtorno obsessivo compulsivo (TOC). Em casos de incapacidade laborativa, o trabalhador deve procurar a Previdência Social para requerer o seu auxílio-doença, benefício concedido ao segurado do INSS acometido por uma doença ou acidente que o torne temporariamente incapaz para o trabalho. Mas qual a relação entre a psiquiatria e a perícia realizada pelo INSS?
Interconsulta psiquiátrica
Authors: Minervino Alfredo José , Gomes Euclides
Published: September 2023

“Interconsulta psiquiátrica”, termo que se refere à prática psiquiátrica em hospitais gerais. A inserção da psiquiatria nos hospitais gerais é um grande desafio da atualidade, visto que os pacientes estão sob os cuidados de outros especialistas, em tratamento de outras patologias. Considerada uma área de conhecimento que se encarrega da assistência, ensino e pesquisa da interface da psiquiatria e demais especialidades médicas, a interconsulta avalia e indica um tratamento psiquiátrico para pacientes que estão sob o cuidado de outros especialistas. Neste trabalho, há a necessidade de investigação das causas orgânicas para os sintomas psiquiátricos de pacientes que estão internados em hospitais gerais.
O papel da mulher na sociedade atual
Authors: Silva Antônio Geraldo da , Abdo Carmita Helena Najjar
Published: September 2023

Durante todo o mês de março, a Associação Brasileira de Psiquiatria – ABP celebra o mês da mulher. Além da campanha “Orgulho de Ser Psiquiatria – Especial Mês da Mulher”, o programa ABP TV discutirá o tema “O papel da mulher na sociedade atual”. Nas últimas décadas, os diversos espaços sociais têm sido cada vez mais ocupados pelas mulheres. Antes relacionada ao ambiente doméstico, a mulher hoje possui mais autonomia, liberdade de expressão e escolha, além da emancipação profissional, com novas possibilidades.
Como integrar a espiritualidade ao tratamento do transtorno por uso de álcool e outras substâncias?
Authors: Pinto Alexandre de Rezende , Mosqueiro Bruno Paz , Castaldelli-Maia João Maurício
Published: September 2023

A espiritualidade atua como um importante fator de proteção e de prevenção das doenças mentais e tem atuado como uma grande aliada no tratamento. Mas como podemos integrá-la no tratamento de transtornos causados por álcool e uso de outras substâncias? A espiritualidade auxilia como impeditivo no abuso de álcool e outras drogas?
Labor attitudes of graduates of higher and secondary specialized educational institutions of the Kabardino-Balkarian Republic. Part 2
Authors: Atlaskirov Albert Ruslanovich
Published: September 2023

The changes taking place in the modern labor market, under the influence of information and technological progress, are fraught with significant risks for the sustainable development of the Kabardino-Balkarian Republic. The process of introducing artificial intelligence into various sectors of the economy has begun, according to experts, will lead to the release of significant labor resources, which may result in an increase in social tension in society. In this regard, it seems necessary to conduct research on the identification of labor attitudes of the younger generation. The purpose of the presented work is to study the labor attitudes of graduates of higher and secondary specialized educational institutions of Kabardino-Balkaria. The conducted research showed that most of the graduates are going to get a job in their region. About a third of the respondents plan to go to work in other regions of the country. Most of the graduate students of the universities of the republic had already worked by the time of the survey, but a significant part did not work in their specialty. Low efficiency is shown by career guidance work. Many young people do not receive up-to-date information about the potential directions of economic and labor market development, and school career guidance lessons do not arouse their interest. Respondents consider IT industry and tourism to be the most promising areas of development of the republic's economy.
Modeling Concept Structure at the Stage of Ideologeme Destruction (based on the Concept LABOR in the Russian Worldview of 1980s-2000s)
Authors: Meng Qin
Published: September 2023

The paper analyzes the concept LABOR in the Russian worldview on the basis of 1980-2000 publicist contexts. The source of the material is the journalistic subcorpus of the “National Corpus of the Russian Language”. The main cognitive features of the concept LABOR are identified by analyzing semantics, pragmatics and contextual partners of the key lexemes representing the concept. The analysis of 500 publicist contexts has shown that the concept LABOR in publicist discourse possesses a variety of cognitive features, which indicates a multi-level structure of the concept. We distinguish three types of these features: anti-ideological, ontological (of objective and subjective nature), and social. All the three are due to the external historical changes, are relatively unstable and “responsible” for the structural changes of the concept. The analysis concludes that the Soviet regime and the historical situation had a significant impact on the language consciousness and mentality of native speakers at the conceptual and value levels. In the structure of the concept LABOR, the main changes are associated with the following components: subject, object, characteristics of labor, result, process, and addressee of labor. The most significant changes related to deideologization affected the blocks of ideas about the subject and addressee of labor (destruction of the idea about collective labor for the benefit of the country).
Methodological Features of Studying Students’ Language Consciousness and Mental Lexicon
Authors: Yakovlev A. A.
Published: September 2023

The paper discusses methodological issues of student language consciousness research. The analysis of publications dealing with the language consciousness of a student leads us to the formulation of the main methodological principles. These are: the choice of linguistic signs (stimuli) relevant for the main respondents’ activity and adequate to it and a relevant method of processing collected empirical data (in order) to reflect (or to detect) features of one’s main regular activities, representing their individual personal evaluative assessments of the activity under study and to minimize the part of misleading odd casual reactions from respondents. The general conclusion of the study is as follows: in the students’ language consciousness images of the academic setting, its objects and phenomena are always refracted by their personal perceptions of these phenomena.
Comparative study between conventional crystalloid cardioplegic solution with modified del nido cardioplegia in mitral valve regurgitation surgery
Authors: Seleem Tarek Abdelsalam , Abdelhalim Aboelsuod Mohamed Abdelgawad , Mahmoud Mohamed Hussienny , Shaaban Abdelazeem Mostafa
Published: September 2023

Background: Cardioplegia is crucial for protecting the heart. Long-term cardiac protection is offered by the Del Nido Cardioplegia solution (dNCS). Aim: To compare conventional crystalloid cardioplegia with modified del Nido cardioplegia in mitral valve regurgitation replacement surgery. Objectives and Methods: This randomized clinical study included 80 patients undergoing to elective mitral regurgitation replacement surgery of both sex and age from 21 to 60 years with ASA (III and IV). All 80 patients were randomly assigned to receive conventional cardioplegia (St. Thomas’ cardioplegic solutions) or to obtain a modified del Nido cardioplegia (using normal saline) (groups A and B, respectively). The laboratory data for assessment of myocardial protection were obtained through measurements of preoperative serum levels of cardiac enzymes as, CK-MB, troponin, and lactate, immediately after operation, 12 and 24 hours postoperatively. Results: There was a significant increase in CK-MB only after 1 h (p < .001) in group (A) and after 12 h. CK-MB and lactate levels were significantly increased (p < 0.05). Also, after 24 h. CK-MB and Troponin T levels were significantly increased (p < .001). Regarding complications, one patient had atrial fibrillation and one case had permanent stroke in group (A), and two patients died in group (A), while one patient died in group (B) without a significant difference between the groups. Conclusions: We report that Modified Del Nido Cardioplegia has better postoperative chemical parameters as CK-MB, Troponin T and Lactate in mitral valve surgery in adults. DNC is a safe alternative to conventional cardioplegia and has achieved at least the same results.
Relationship between Serum Sex Hormones and Coronary Artery Disease in Premenopausal Women – A Missing Link?
Authors: Sahu Ankit Kumar , Khanna Roopali , Kumar Sudeep , Garg Naveen , Tewari Satyendra , Kapoor Aditya , Goel Pravin K
Published: September 2023

Objectives:

The reported incidence of coronary artery disease (CAD) is on the upsurge in middle-aged women of 35–54 years, whereas decreasing in similar aged matched men. The current clinical trial studies have revealed that attention is drawn away from estrogens and shifted toward androgens and sex hormone-binding globulin considered potential mediators of increasing cardiovascular risk in women at midlife. Data evaluating the endocrinological basis for CAD in premenopausal Indian women is infrequent. We aimed to assess the incidence of CAD among premenopausal women undergoing coronary angiography, identify the prevalence of various risk factors for CAD, and compare clinical characteristics and hormonal levels among premenopausal women with and without CAD to elucidate endocrinological explanations for CAD in premenopausal women.

Materials and Methods:

Ninety-nine consecutive premenopausal women undergoing coronary angiography between January 2014 and January 2017 were enrolled in this single-center and cross-sectional study. The reproductive hormone levels were quantified using commercially available electrochemiluminescence immunoassay.

Results:

Sixty-six (66.7%) premenopausal women had CAD on coronary angiography. Multivariate linear regression analysis was used, for diabetes mellitus (adjusted odds ratio [AOR] 16.46; P = 0.006 [95% confidence interval, CI: 2.21–122.41]), triglycerides (AOR 1.05; P = 0.002 [95% CI: 1.02–1.10]), progesterone (AOR 0.68; P = 0.015 [95% CI: 0.50–0.93]), and insulin (AOR 0.51; P < 0.0001 [95% CI: 0.38–0.70]) were observed to independently anticipate the development of CAD in premenopausal women.

Conclusion:

Approximately two-thirds of premenopausal women undergoing coronary angiography are detected to have CAD. Patients having diabetes, high serum triglyceride levels, low progesterone, and low insulin levels are considered in the high-risk category for developing CAD, thereby in premenopausal women providing a hormonal basis for the development of CAD.
CATHETER-ASSOCIATED BLOODSTREAM INFECTIONS IN INTENSIVE CARE: CURRENT STATUS OF THE PROBLEM
Authors:   Grodno University Clinic, Grodno, Belarus, Stanko O. V. , Yakubtsevich R. E. ,   Grodno State Medical University, Grodno, Belarus, Balla A. A. ,   Grodno University Clinic, Grodno, Belarus, Dubrovschik A. V. ,   Grodno University Clinic, Grodno, Belarus
Published: September 2023

Effective treatment of Intensive Care Unit patients is closely related to the requirement to create a temporary or permanent vascular access for renal replacement therapy, infusion and transfusion therapy and monitoring the patient's condition. The devices used for this purpose – intravascular catheters – are a potential threat to the patient, as they create the possibility of microorganisms’ access to the systemic bloodstream, by successfully negating the natural defense mechanisms. The review considers significant factors and pathogenetic mechanisms leading to the realization of infection potential in the presence of a vascular catheter in the bloodstream – catheter-associated infection, as well as diagnostic possibilities, approaches to pathogenetically justified therapy and complex prevention with regard to the achievements of modern medical science and practice.
Investigating the photodynamics of trans-azobenzene with coupled trajectories
Authors: Pieroni Carlotta , Sangiogo Gil Eduarda , Ibele Lea-Maria , Persico Maurizio , Granucci Giovanni , Agostini Federica
Published: September 2023

In this work, we present the first implementation of the coupled-trajectory Tully surface hopping (CT-TSH) suitable for applications to molecular systems. We combine CT-TSH with the semiempirical Floating Occupation Molecular Orbitals-Configuration Interaction (FOMO-CI) electronic structure method to investigate the photoisomerization dynamics of trans-azobenzene. Our study shows that CT-TSH can capture correctly decoherence effects in this system, yielding consistent electronic and nuclear dynamics in agreement with (standard) decoherence-corrected TSH. Specifically, CT-TSH is derived from the exact factorization and the electronic coefficients’ evolution is directly influenced by the coupling of trajectories, resulting in the improvement of internal consistency if compared to standard TSH.
Modeling lithium plating onset on porous graphite elec- trodes under fast charging with hierarchical multiphase porous electrode theory
Authors: Lian Huada , Bazant Martin
Published: September 2023

Lithium plating during fast charging of porous graphite electrodes in lithium-ion batteries accelerates degradation and raises safety concerns. Predicting lithium plating is challenging due to the close redox potentials of lithium reduction and intercalation, obscured by the nonlinear dynamics of electrochemically driven phase separation in hierarchical pore structures. To resolve dynamical resistance of realistic porous graphite electrodes, we introduce a model of porous secondary graphite particles to the multiphase porous electrode theory (MPET), based on electrochemical nonequilibrium thermodynamics and volume averaging. The resulting computational framework of "hierarchical MPET" is validated and tested against experimental data over a wide range of fast charging conditions and capacities. With all parameters estimated from independent sources, the model is able to quantitatively predict the measured cell voltages, and, more importantly, the experimentally determined capacity for lithium plating onset at fast 2C to 6C rates. Spatial and temporal heterogeneities in the lithiation of porous graphite electrodes are revealed and explained theoretically, including key features, such as idle graphite particles and non-uniform plating, which have been observed experimentally.
Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging
Authors: Mrestani Achmed , Dannhäuser Sven , Pauli Martin , Kollmannsberger Philip , Hübsch Martha , Morris Lydia , Langenhan Tobias , Heckmann Manfred , Paul Mila M
Published: September 2023

Chemical synaptic transmission involves neurotransmitter release from presynaptic active zones (AZs). The AZ protein Rab-3-interacting molecule (RIM) is important for normal Ca2+-triggered release. However, its precise localization within AZs of the glutamatergic neuromuscular junctions ofDrosophila melanogasterremains elusive. We used CRISPR/Cas9-assisted genome engineering of therimlocus to incorporate small epitope tags for targeted super-resolution imaging. A V5-tag, derived from simian virus 5, and an HA-tag, derived from human influenza virus, were N-terminally fused to the RIM Zinc finger. Whereas both variants are expressed in co-localization with the core AZ scaffold Bruchpilot, electrophysiological characterization reveals that AP-evoked synaptic release is disturbed in rimV5−Znfbut not in rimHA−Znf. In addition, rimHA−Znfsynapses show intact presynaptic homeostatic potentiation. Combining super-resolution localization microscopy and hierarchical clustering, we detect ∼10 RIMHA−Znfsubclusters with ∼13 nm diameter per AZ that are compacted and increased in numbers in presynaptic homeostatic potentiation.
KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells
Authors: Hey Sven , Wiesner Christiane , Barcelona Bryan , Linder Stefan
Published: September 2023

The matrix metalloproteinase MT1-MMP is a central effector of cellular proteolysis. Accordingly, regulation of the surface-localized pool of MT1-MMP is crucial for cell migration and invasion. Here, we identify the superprocessive kinesin KIF16B as a major driver of fast recycling of MT1-MMP to the surface of primary human macrophages. KIF16B associates with MT1-MMP on Rab14-positive vesicles, and its depletion results in strongly reduced MT1-MMP surface levels, as shown by microscopical, biochemical, and cell-sorting approaches. As a consequence, KIF16B-depleted macrophages exhibit strongly reduced matrix degradation and invasion. We further identify the cargo-binding C-terminus of KIF16B as a critical element of MT1-MMP transport, as its overexpression uncouples MT1-MMP vesicles from the endogenous motor, thus leading to a reduction of surface-associated MT1-MMP and to reduced matrix degradation and invasion. Importantly, depletion of KIF16B in primary macrophages also reduces the co-invasion of cancer cells from tumor spheroids, pointing to the KIF16B-driven recycling pathway in macrophages as an important regulatory element of the tumor microenvironment.
FUNGSI KESENIAN BELUK PADA MASYARAKAT ADAT KASEPUHAN CICARUCUB
Authors: Tila Rita
Published: September 2023

Beluk from the Indigenous People of Kasepuhan Cicarucub are still maintained by the community based
on their beliefs. The purpose of this research is to find out how the situation, events and functions of Beluk
by the community in preserving their culture. In this study, the authors use the ethnographic theory
of communication put forward by Dell Hymes. The method used in this research is qualitative with an
ethnographic communication approach. Data collection techniques through interviews and document
observation. To determine the informants used non-random sampling technique, namely purposive
sampling. The data validity test technique used is the data triangulation technique which consists of
interviews, observation and documentation. The data analysis technique used is to describe the findings
in detail from the interpretation results, then draw conclusions on the research results obtained. The
conclusion is that Beluk art has a purpose for education, morals and manners. The function of outs and
outs in the traditional Kasepuhan Cicarucub community is a religious function, a social function and an
entertainment function.
Keywords: Function, Outline Art, Kasepuhan Cicarucub Indigenous People
PERAN PEREMPUAN DALAM MELESTARIKAN KESENIAN RAMPAK BEDUG DI KABUPATEN PANDEGLANG
Authors: Permanasari Alis Triena , Rizal Syamsul
Published: September 2023

Perempuan dalam Kesenian Rampak Bedug menjadi sebuah simbol. Rampak Bedug
yang ada di Kabupaten Pandeglang hampir rata-rata menghadirkan perempuan dalam
pertunjukannya. Selain itu, peran perempuan dalam eksistensinya menjadi ciri khas dalam
kesenian tersebut. Tujuan penelitian ini untuk membahas dampak peran perempuan dalam
upaya keberlangsungan Kesenian Rampak Bedug di Kabupaten Pandeglang. Mengingat
sosok perempuan dalam kesenian ini menjadi sorotan bagi masyarakat umum. Penelitian ini
merupakan penelitian kualitatif dengan pendekatan fenomenologi. Objek penelitian ini yakni
sanggar Pamanah Rasa Kabupaten Pandeglang. Subjek dalam penelitian ini adalah perempuan
yang sedang menuntut ilmu di pendidikan non-formal (sanggar seni) atau pelaku seni di
sanggar Pamanah Rasa. Pengumpulan data menggunakan observasi langsung, wawancara
mendalam, dan dokumentasi. Analisis data menggunakan kajian wanita dan kajian seni. Hasil
penelitian dalam upaya pelestarian rampak bedug melalui keterlibatan secara aktif di sanggar,
peningkatan apresiasi kepada masyarakat umum, dan terlibat dalam pengembangan dan
pengemasan Kesenian Rampak Bedug.
Kata Kunci: perempuan, rampak bedug, budaya lokal
STRATEGI PERSONAL BRANDING PENARI LENGGER LANANG MELALUI MEDIA INSTRAGRAM PADA AKUN INSTRAGRAM @RIANTO_RDS
Authors: Widyaningrum Septiana Yustika , Sjuchro Dian Wardiana , Indriani Sri Seti
Published: September 2023

Penari lintas gender merupakan profesi yang masih dianggap tabu. Hal ini menjadikan kelompok

penari lintas gender menjadi termarjinalkan. Eksistensinya dianggap minor, sehingga membuat

mereka tidak memiliki akses yang sama dalam menampilkan personal branding-nya. Namun, bagi

Rianto, penari Lengger Lanang, keberadaan Instagram menjadi jalan alternatif untuk memfasilitasi

dirinya menampilkan personal branding dirinya sebagai penari lintas gender, baik secara profesional

maupun personal. Penelitian ini membahas tentang bagaimana strategi personal branding Rianto,

seorang penari Lengger Lanang Banyumas yang memiliki misi budaya untuk melestarikan kesenian

tersebut melalui personal branding di media Instagram. Metode penelitian yang digunakan adalah

deskriptif kualitatif dengan indikator yang terdiri atas sebelas karakteristik authentic personal

branding menurut Rampersad. Hasil penelitian menyebutkan bahwa strategi personal branding

Rianto adalah memiliki nilai, karakter, kode perilaku, dan moral, yang berfokus pada bidang

kesenian, konsisten, memiliki relevansi, visibilitas, mendapatkan pengakuan, menerapkan hal

positif, menjadi diri sendiri, menjaga eksistensinya, dan memelihara hubungan baik pada pengikut

di akunnya.

Kata kunci: Personal branding, Penari Lintas Gender, Media Sosial, Strategi
How has Covid Impacted the Call for Reform for the Criminal Justice System?
Authors: Sinkoff Olivia
Published: September 2023

Since 2002, the United States has held the highest incarceration rate in the world.150 Today, there are around two million people incarcerated in U.S. state and federal prison, local jails, and non-voluntary mental health facilities– many of whom have yet to be convicted. There are 445,000 people in local jails and another 88,000 in federal prisons who are detained before their trial because they cannot afford bail payment.151 The detainment rate increased exponentially between 1980 and 1996, primarily as a result of the War on Drugs which was a government initiative started by President Nixon to dissuade drug abuse. Nixon increased federal financial support for drug-control agencies and implemented rigid laws and punishments for drug offenders.152 Critics of the War on Drugs have pointed out that it has disproportionately affected people of color – the increase in incarceration rates for Black Americans and Hispanics during the seventeen years the policy was active was one and a half times and three timesrespectively, higher than the increase for white Americans. The larger increase in incarceration rates for minorities is evidence of systemic racism in the criminal justice system, which has prompted numerous calls for reform. Advocacy for reform was amplified in May 2020, following the murder of George Floyd and as the COVID-19 pandemic placed heavy burdens on the criminal justice system. During this period, the Defund the Police movement assumed the mantle for criminal justice reform. The criminal justice system tried to prevent the spread of the virus by releasing thousands of inmates early. 153 Less than 0.2 percent of those inmates released have committed new crimes, pushing the question of the integrity of the United States’ system of incarceration to the forefront of social justice concerns.
COMPARATIVE LAW: In Search of a Muslim Identity Between the Two Extremes of Secularism and Religious Law
Authors: Rao Gali Amogha
Published: September 2023

This paper analyses the development of the Indian Muslim identity with respect to the coexistence of Shariat and sovereign laws. The period of analysis is postcolonial India. The paper analyses the different conflicts of legal philosophy and practice that exist between the judiciary of India and that of the parallel Islamic system. The conflict is such that private citizens suffer from wrongful interpretation of religious law and there is an infringement of the fundamental right to justice as guaranteed by the sovereign laws to every Indian citizen. The analysis begins with a brief discussion of a case that involved a conflict of laws and, vicariously, a conflict of legal ideology between the two systems. The paper mentions other similar cases in corroboration of the primary claim—conflict of legal philosophy. The views of the Indian State are considered with special reference to the idea of secularism in the Indian context. The Constitution of India is analysed to establish as to what the word 'secular' means under the Supreme Law of the Indian State. The analyses reveal that the parallel system, although impractical serves the cause of meeting the Indian idea of secularism. The paper concludes that the secular ethos of Indian democracy allow for infringement of certain Common Law values to make space for certain religious laws, even though they are more conflictive than complimentary
Ensuring the Power of the Beth Din: Creation of the Halakhic Prenuptial Agreement
Authors: Fernands Anna
Published: September 2023

One purported solution to the agunah problem is the halakhic prenuptial agreement. This paper examines the process that created the halakhic prenup through focusing on the Conservative movement’s adoption of the Lieberman Clause, the Koeppel v. Koeppel case, and the growing Orthodox feminist movement. In examining the cultural forces that led to the creation of the halakhic prenup, it becomes clear that the Orthodox Rabbinate designed the halakhic prenup to secure the power of the Orthodox Beth Din. The halakhic prenup was created as a direct result of increasing numbers of Jewish women turning to secular courts for a solution to the agunah problem
Development of mobile power production taking into account agrotechnological limitations
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, LEVSHIN A.G.
Published: September 2023

The problem of finding the optimal ratio of mass, power, and working speed has been and remains an urgent task since laying the groundwork of agricultural mechanics. The concept of development aimed at increasing the productivity and operating speeds of machine-tractor units, has led to an increase in unit power and the mass of machines. An analysis of the development trends of tractors and self-propelled machines showed an annual increase in the average power of newly designed tractors by 2 to 4 hp. Capacity implementation of equipment with increased energy saturation is possible due to an additional increase in the mass of machines, which results in increased soil compaction. Critical stresses reaching a significant depth do not contribute to the process of complete relaxation of the soil. In the uncultivated layer, a soil horizon is formed between 25 to 30 and 100 to 120 cm (with a hardness corresponding to a clay rolled road), limiting the development zone of the plant root system and disturbing soil filtration. The intensive use of energy-saturated units and self-propelled machines has led to the accumulated overconsolidation of the uncultivated layer of more than 60% of arable land. Soil overconsolidation along the wheel track leads to a decrease in the yield of grain crops by 10% and root crops by 20%. When modernizing or designing new models of machines, we suggest taking into account the negative environmental consequences of the use of units in the feasibility study and reworking the regulatory and methodological documents for assessing the specific pressures on the soil of the running gear parts of self-propelled machines. It is necessary to reduce the machine load on the soil by using smaller machines and by implementing measures to loosen the subsoil horizon. Equally important is to determine the parameters and design a line of robotic energy systems, a set of working equipment and a control system based on the principles of multi-agent control of sets of dynamic objects in relation to agricultural production.