bluuebunny/crossref_metadata_2025 huggingface dataset:
La actividad económica del empresario José Bunster en la frontera de la Araucanía, 1857-1903
Authors: Inostroza Córdoba Luis Iván , Flores Chávez Jaime , Pinto Rodríguez José
Published: June 2020

El presente artículo analiza la trayectoria empresarial de José Bunster durante la ocupación de los territorios fronterizos de la Araucanía, en el sur de Chile, entre las décadas de 1860 y 1890. Bunster tuvo un destacado papel en el desarrollo de la agroindustria de molinos y de créditos destinados a impulsar la puesta en producción de los predios adquiridos por otros agricultores. Asimismo, aportó mediante diversos factores y mecanismos a dinamizar la conformación de un mercado agrario moderno en la zona interior de la frontera mapuche, conectada con los enclaves mercantiles del puerto de Talcahuano y de la ciudad de Concepción.
Suriye İç Savaşi Açısından Zeytin Dalı (Afrin) Harekatı
Authors: BAYRAKTAR Bora
Published: June 2020

Ortadoğu’da Arap isyanları olarak adlandırılan 2011’deki protesto dalgası sonrası gelişen iç çatışmalar bölgede kaba güç olarak tabir edilen askeri güç kullanımını öne çıkarmaktadır. Türkiye de bölgesinde önemli bir aktör olarak özellikle 24 Ağustos 2016’da başlattığı Fırat Kalkanı Harekatı ile askeri güç kullanarak hem kendi güvenliğini koruma hem de Suriye iç savaşında bir sınır komşusu olarak oynadığı rolün ağırlığını arttırmak üzere hamleler yapmıştır. Türkiye 20 Ocak 1018’de de “terörle mücadele” ve “hudut bölgesi güvenliği” kapsamında Suriye’nin Afrin vilayetinde de bir askeri harekat düzenlemiştir. Türkiye’nin hukuksal zeminini “meşru müdafaa” üzerine oturttuğu bu harekat Suriye iç savaşındaki dengeleri de etkileyen önemli bir adım olmuştur. Bu çalışmada Zeytin Dalı Harekatı’nın nasıl bir konjonktürde gerçekleştirildiği ve Suriye iç savaşına olası etkileri değerlendirilmektedir.
MENERAPKAN MANAJEMEN STRATEGI PENYIARAN UNTUK PENYIARAN DAKWAH
Authors: Dawud Mochammad
Published: June 2020

Managing broadcasting television is not thc samc as managing companies in general. Moreover if there is a da’wah mission. Management concepts are not necessarily applicable in broadcasting management. Integrating it means balancing thc interests of the media owner and the public as thc audience as well as thc owner of the rights to the frequency managed by the broadcast media. While broadcasting media must continue to function as a means of entertainment, information, public services and economic functions. Broadcasting media management places more emphasis on planning, which include positioning, segmentation, targeting, formatting and programming. The rest, broadcasting management concepts are almost the same as management in general. ln the end, concepts in the political economy of the mcdia rcmain decisive in winning audience choice, including the broadcasting media which carrying da’wah mission. These concepts include: commodification, spacialization and structuration.
Dinamisasi Pesantren Perspektif KHAS dalam Konstruksi Majalah Pesantren Tahun 1985
Authors: Wazis Kun
Published: June 2020

The perspective of a Kyai (a Javanese expert in Islam) in critically perceiving Islamic scholars becomes an important discourse in the changing face of Pesantren (Islamic boarding schools) from time to time. Kyai Haji Ahmad Shiddiq (KHAS) was one of the most notable figures who had extensive experiences in establishing this classical Islamic institution specific to Indonesia. In order to accentuate the great services of the late Jember figure, the State Islamic Institute of Jember (IAIN Jember) proposed the name KHAS as the new identity for the proposed institutional change status to become State Islamic University (UIN).

This study attempted to explain KHASâ€™ perspective on Ulama (Islamic scholars) and Pesantren whose original thoughts were written in Pesantren Magazine in 1985. Employing a qualitative approach, focusing on text analysis of KHASâ€™ articles, an overview was obtained about the credibility of Ulama, the identity of Kyai, and the dynamics of Pesantren in Indonesia at that time and in the future to come.

The results of the current study confirmed three important things. First, Ulama inherit the leadership roles of the Prophet Muhammad PBUH in terms of knowledge, deed, and morality. Second, the identity of a Kyai is presented to individuals who have reached the level of Ulama. Third, the dynamics of Pesantren community are carried out with two types of improvement, namely recovery and development.
Los roles de género en la música infantil de la plataforma digital Youtube
Authors: Juárez Rodríguez Javier
Published: June 2020

El presente artículo analiza la representación de los roles de género reproducidos en los tres principales canales de música infantil de YOUTUBE: El Reino Infantil, La granja de Zenón y Toy Cantando. Los tres cuentan con más 40 millones de suscriptores, jugando un papel importante en el proceso de socialización y consolidación de imaginarios entre los más pequeños. El trabajo tiene como objetivo estudiar un total de 30 videos/canciones, los diez más vistos de cada canal, aplicando para ello la perspectiva de género de forma transversal en su análisis, priorizando su estudio en torno a tres áreas o campos de análisis: 1. Estudio de los roles protagónicos 2. Representación de los modelos de feminidad y masculinidad 3. Análisis del universo simbólico y la interrelación de los personajes. El trabajo aborda el papel de la música como un agente socializador capaz de plasmar e incluso fortalecer los valores de una sociedad determinada, a la vez que promover cambios y replantear la validez del sistema y sus principios. Uno de los objetivos de la investigación se centra en analizar tanto las letras de las canciones como su representación audiovisual en los videos seleccionados, llevando a cabo, para ello, un análisis sobre las representaciones y los roles de género en los personajes protagónicos de las historias.
Utilidad de las tutorías académicas en la universidad
Authors: Pérez-Serrano María José , Rodríguez-Pallares Miriam , González-Alonso María Yolanda
Published: June 2020

La tutoría es la acción de orientación presencial o virtual que el docente lleva a cabo sobre el alumnado y que consiste en una ayuda particular entendida como algo intrínseco al proceso educativo del estudiante que suscita su interés, estimula su comportamiento y propone metas significativas en su progreso académico. Así definida, la tutoría interesa como factor de calidad en las metodologías de enseñanza-aprendizaje. En este trabajo, desde un prisma cuantitativo, se analiza la eficacia de la acción tutorial vista desde el alumnado con el fin de contribuir a incrementar el aprovechamiento y mejora del trabajo docente. Para ello, la muestra correlaciona las siguientes variables: tres universidades (UBU, UCM y UNIR); dos presenciales y una on-line; dos públicas y una privada; tres titulaciones; dos áreas de conocimiento; dos casos donde prevalecen las tutorías face-to-face y un caso, con contacto digital no directo con el estudiante. Los resultados obtenidos permiten concluir que, aunque las tutorías face-to-face son más valoradas todavía, la modalidad online es cada vez más valorada y útil.
Network Fundamental Diagram Based Routing of Vehicle Fleets in Dynamic Traffic Simulations
Authors: Dandl Florian , Tilg Gabriel , Rostami-Shahrbabaki Majid , Bogenberger Klaus
Published: June 2020

The growing popularity of mobility-on-demand fleets increases the importance to understand the impact of mobility-on-demand fleets on transportation networks and how to regulate them. For this purpose, transportation network simulations are required to contain corresponding routing methods. We study the trade-off between computational efficiency and routing accuracy of different approaches to routing fleets in a dynamic network simulation with endogenous edge travel times: a computationally cheap but less accurate Network Fundamental Diagram (NFD) based method and a more typical Dynamic Traffic Assignment (DTA) based method. The NFD-based approach models network dynamics with a network travel time factor that is determined by the current average network speed and scales free-flow travel times. We analyze the different computational costs of the approaches in a case study for 10,000 origin-destination (OD) pairs in a network of the city of Munich, Germany that reveals speedup factors in the range of 100. The trade-off for this is less accurate travel time estimations for individual OD pairs. Results indicate that the NFD-based approach overestimates the DTA-based travel times, especially when the network is congested. Adjusting the network travel time factor based on pre-processed DTA results, the NFD-based routing approach represents a computationally very efficient methodology that also captures traffic dynamics in an aggregated way.
Geographical Distribution of Power Plants in Iraq in 2015 Using Geographic Information Systems
Authors: Jaffar Zainab Abdul-Zahra
Published: June 2020

The study aims to study the geographical distribution of electricpower plants in Iraq, except the governorates of Kurdistan Region (Dohuk, Erbil, Sulaymaniyah) due to lack of data.

In order to reach the goal of the research was based on some mathematical equations and statistical methods to determine how the geographical distribution of these stations (gas, hydropower, steam, diesel) within the provinces and the concentration of them as well as the possibility of the classification of power plants in Iraq to facilitate understanding of distribution in a scientific manner is characterized by objectively.

The most important results of the research are that there are a number of factors that led to the irregular distribution of these stations in the provinces, which led to a discrepancy due to the existence of variation in the same provinces because of the components (population, security situation, economic, geographical location) There are deterministic determinants forcing the decision maker to create certain type of stations without others in this province without others.
Examine your LENS: A Tool for Interpreting Cultural Differences
Authors: Williams Tracey Rundstrom
Published: June 2020

The Examine your LENS method is a visual, experiential, and memorable technique of four steps to understand cultural differences and intercultural interactions. These steps are grounded in experiential learning theory and utilize the skills, attitudes, and perspectives needed for intercultural competence.  By implementing these four steps, individuals can recognize biases and appreciate a different perspective, as well as actively engage with the local culture. As educators who want our students to be actively involved in their own learning, self-aware, and engaged in the local culture, this technique is an ideal tool.
Evolution of The Handball Talent Care System in Hungary - pilot study
Authors: Juhász Bernadett , Bácsné Bába Éva
Published: June 2020

Development of talents care systems plays an important role in handball today. The goal of the Hungarian Handball Association is to ensure that all children of the same age receive the same training throughout the country. The Association recently introduced a standard feed-back education system. The aim of this research was to demonstrate the evolution of the talent care system, especially the innovations introduced by the Association.

The research method was interviewing handball experts. Five experts answered our questions, former elite players, currently coaches. Based on their responses, it was possible to compare the old and the current status of the training programmes. We may conclude, that the structure of handball training has significantly developed both technically and tactically. Professionals agree, that there are a number of changes have occurred in the theory and methodology of handball. The newly introduced regional, electronic control system – described in the Age Handbook were considered to be useful by the interviewees. According to the results of our pilot study, the new unified educational training system may result in a more successful international presence in the long term.
Quality of Wellness Services in the North Great Plain Region
Authors: Hidvégi Péter , Biró Melinda , Lenténé Puskás Andrea , Tatár András , Bárdos Kinga , Pucsok József Márton
Published: June 2020

Wellness is the philosophy of life in everyday life. In a holistic sense, it is also used as a harmony of physical, mental, and spiritual abilities, basically means prevention, regeneration, relaxation, and fitness. The investigation took place between September and December 2018. Of the 166 participants, 94 were women, and 72 were men. As a result of the research, we can state that respondents are looking for relaxation and relaxation in wellness hotels. Their expectations are related to their age, place of residence, and family status.
VÁZIZOMSÉRÜLÉS KEZELÉSEK JELENLEGI MÓDJAINAK ÁTTEKINTÉSE
Authors: Gyenes Dominik , Budai Zsófia , Sarang Zsolt
Published: June 2020

A harántcsíkolt izomszövetből felépülő vázizmok akaratlagos összehúzódásai a test mozgásait okozzák és jól irányíthatók. A vázizom egyik legjellegzetesebb tulajdonsága, hogy nagyfokú in vivo és in vitro regenerációs képességgel rendelkezik, viszont nagyobb mennyiségű izomvesztés esetén a regenerációs folyamat kimerül, intervenciós támogatást igényel. Ebből következik, hogy az izomsérülés folyamatos kihívást jelent a klinikum számára. Az elmúlt században, különösen az utóbbi néhány évtizedben számos technikát dolgoztak ki az izomregeneráció elősegítése érdekében, ideértve a különböző műtéti technikákat, a fizikoterápiát, a biológiai anyagokat, az izomszövettenyésztést, krioterápiát, mágneses mező alkalmazását, valamint a sejtterápiát. Ugyanakkor továbbra is nagy igény mutatkozik új módszerek és anyagok kifejlesztésére, melyek elősegítik a vázizom megfelelő érését és a funkcionális regenerációt. Ebben a tanulmányban átfogó képet adunk az izomszövetveszteség epidemiológiájáról, rávilágítunk a klinikai kezelés aktuális stratégiáira, és megvitatjuk az izomregeneráció új módszereit, a jövőbeli klinikai átalakulásuk kihívásait.
FOGYASZTÓI MOTIVÁCIÓS VIZSGÁLATOK A DVSC LABDARÚGÓ CSAPATÁNAK BÉRLETESEI KÖRÉBEN
Authors: Komáromi Dominika Anna , Bácsné Bába Éva
Published: June 2020

Jelen tanulmányban a DVSC labdarúgó mérkőzéseit bérlettel látogató szurkolók szocio-demográfiai jellemzőit és összetételét vizsgáltuk, illetve a debreceni közönség sportfogyasztását meghatározó motivációs tényezőket mértük fel. A szakirodalmi források feldolgozása után elkészítettük a mérőeszközt, mely szocio-demográfiai, mérkőzéslátogatási szokásokkal, létesítménnyel és szolgáltatásokkal, illetve belépőkkel, jegyárakkal kapcsolatos kérdéseket tartalmazott. Az adatokat személyes és online formában is gyűjtöttük, így összesen 49 fős mintát vizsgáltunk. Az eredmények kiértékelése során kiderült, hogy a DVSC bérlettel rendelkező szurkolói úgy a csapat sikerét, mint kudarcát sajátjukként élik meg. Összességében megállapítható, hogy az állandó belépővel rendelkezők biztos résztvevőket jelentenek, számuk növelése kulcsfontosságú a klub számára, mely a csapat és a szurkoló közötti kötelék létrehozásával és erősítésével valósítható meg.
Examination of the Relationship Between Physical Activity and Cognitive Skills
Authors: Makra Gabriella , Balogh László
Published: June 2020

Introduction: Examining physical activity and cognitive function has become a popular topic of research since the quality of these two components influences our quality of life and performance. It is very important for both sexes, all ages and life situations.

Objective: Determining a type of physical activity (PA) that has an effect on both cognitive functions (CF) and motor skills and performance. Clarifying or promoting measurement methods, or developing new methods that meet current standards and objectives. The results may be used to help to impove performance in all areas.

Method: Primary purpose of our study was to conduct a review, in order to summarize the relevant literature on the following topics: sex, age, fitness level, possible illness.

Conclusions: We found a significant relationship between cognitive functions and physical activity, which can be transposition in a proper way, both in terms of living standards and performance. On the other hand, there are a lack of uniform, accurate measurement methods. Thhere is a need for specific physical activity routines that specifically improve the level of cognitive function, even at an older age.
The Impact of European Youth Basketball League (EYBL) on the Development of the U16 Men’s Basketball Teams
Authors: Dara Lilla Csenge , Bácsné Bába Éva
Published: June 2020

The main focus of our research was the U16 age group since it is one of the most significant in terms of the young athlete’s future - probably professional - career. It was very helpful in research that this age group was a priority in the Basketball Academy of Debrecen’s program and they were competing in an international basketball league, in the European Youth Basketball League (EYBL). Thanks to the EYBL tournaments we have got a chance to analyze this youth category completely. For primer research we have chosen three teams, two Hungarian, and one Italian, to get an impression why is so important to play basketball at the international level in this age.  We have made interviews with the coaches, organizers and the manager of the league to have an international comparison of this age group.
Putting the Fetus First — Legal Regulation, Motherhood, and Pregnancy
Authors: Milne Emma
Published: June 2020

The fetus-first mentality advocates that pregnant women and women who could become pregnant should put the needs and well-being of their fetuses before their own. As this Article will illustrate, this popular public perception has pervaded criminal law, impacting responses to women deemed to be the “irresponsible” pregnant woman and so the “bad” mother. The Article considers cases from Alabama and Indiana in the United States and from England in the United Kingdom, providing clear evidence that concerns about the behavior of pregnant women now hang heavily over criminal justice responses to women who experience a negative pregnancy outcome or who are perceived to have behaved in a way that could result in a negative outcome. This Article provides a new approach by bringing together a critical assessment of fetal protection laws with theories of motherhood ideologies and analyzing how such ideologies have resulted in legal developments not only in the US, where the fetus has been granted legal recognition in most states, but also in England and Wales, where the fetus continues to have no legal personality. The Article will conclude that the application of the fetus-first mentality within criminal law has resulted in dangerous legal developments that challenge women’s rights, while doing little to protect fetuses.
AD endotypes evaluation with molecular-genetic analysis of local immune response
Authors: Elisyutina O G , Boldyreva M N , Rebrova O Yu , Fedenko E S
Published: June 2020

The basis for the development of atopic dermatitis (AD) is genetic predisposition, hypersensitivity to allergens, Th1/Th2 disbalance, increased degranulation of mast cells and antigen-presenting activity of Langerhans cells, as well as epidermal barrier dysfunction. Recently, genotypes, phenotypes and endotypes of AD, and biomarkers, which can be used to assess the effectiveness of therapy and to develop personalized approaches to the diagnosis, treatment and prognosis of the disease, have been actively studied. The aim of this study was to determine the endotypes of atopic dermatitis on the basis of molecular genetic study of cytokine gene expression in the skin of AD patients. Materials and methods. The study was performed as a «case-control», 90 AD patients and 30 healthy individuals without signs of atopy were included. The material for evaluation of cytokine gene expression was skin biopsy samples taken by punch biopsy. The level of gene expression was determined by real-time PCR with preliminary reverse transcription of mRNA of the corresponding genes («DNA-Technology», Moscow). The transcript levels of ILB, IL2, IL2r, IL4, IL5, IL6, IL7, IL8, IL10, IL12A, IL12B, IL15, IL17A, IL18, IL23, IL28, IL29, IFNy, TNF, TGFß, FOXP3 genes were studied. Results. Based on the molecular genetic study of the local immune response the following endotypes of AD were determined: endotype with predominance of Th1-type immune response (3% of patients); endotype with predominance of Th2-type immune response (3% of patients); mixed endotype with increased expression of IL2 (20% of patients); mixed endotype with reduced expression of IL10 (64% of patients); mixed endotype with increased expression of TGFß (9% of patients). Clinically significant biomarkers of inflammation in atopic dermatitis - decreased mRNA level of IL1ß gene expression and increased mRNA level of IL2R, IL4, IL5, IL6, IL8, IL10, IL12ß, IL23, IL29, IFNy and TGFß genes expression were determined in the skin of AD patients compared to healthy individuals. Conclusion. The use of molecular genetic method for evaluation of local immune response on the basis of cytokines gene expression measurement in the skin allows to identify the most significant biomarkers characterizing different endotypes of AD, and to determine the type of immune response in the individual patient.
Allergen-specific immunotherapy using pollen allergens in cross-reactive food allergy: what do we know?
Authors: Ereshko O A , Makarova S G , Namazova-Baranova L S
Published: June 2020

Cross-reactive food allergy to plant-based products can lead to a significant increase in morbidity and impairment of quality of life, therefore it is important to analyze the literature data on the effectiveness of conventional and available methods of AIT in these patients.
Allergy to lemon: case of oral allergic syndrome associated with allergic otitis media and labyrinthitis in a patient with polysensibilization and multiple manifestations of allergy
Authors: Prilutskiy O S , Lyhina Yu A
Published: June 2020

Oral allergic syndrome is an IgEmediated allergic reaction to foods of plant origin in persons with sensitization to various pollen allergens. A clinical case of oral allergy syndrome caused by consumption of lemon in a 25-year-old woman with sensitization to many groups of allergens and presence of allergic otitis media and allergy-induced labyrinthitis is presented. The patient had a history of seasonal allergic rhinoconjunctivitis, bronchial asthma, contact allergic dermatitis, urticaria as a manifestation of drug allergy. In vivo (skin prick tests, prick-prick tests) and in vitro allergen specific diagnostics allowed to work out the individual diet and a hypoallergenic regime in this case.
Assessment of cytokine profile and T-lymphocyte subpopulations in blood serum in children with allergic diseases of the respiratory system
Authors: Prosekova E V , Turyanskaya A I , Plekhova N G , Dolgopolov M S , Sabynych V A
Published: June 2020

Expansion of the range of examined T-helper clones has determined more complex immune mechanisms for the implementation of allergic inflammation. Objective. To characterize the parameters and relationships between the serum cytokine profile and T-lympho-cyte subpopulation in peripheral blood of children with bronchial asthma and allergic rhinitis. Materials and methods. 150 children aged between 3-11 years old with bronchial asthma, and allergic rhinitis and 30 healthy volunteers were examined. Immunological parameters were assessed by flow cytometry, the concentration of serum interleukins and IgE were determined by means of enzymelinked immunosorbent assay. Statistical analysis was performed with «Statistica 10» program with a critical level of significance p
Exercise induced bronchoconstriction in elite athletes
Authors: Tsarev S V , Ilina N I , Khaitov M R
Published: June 2020

The problem of exerciseinduced airway hyper responsiveness and bronchial obstruction is discussed in the review. Epidemiological data on the prevalence of bronchial obstruction in elite athletes of various sports are presented. Modern concepts of etiological and trigger factors caused by exercise induced bronchospasm are considered. Pathogenetic aspects of the formation of bronchial obstruction in athletes are presented.
Allergenic extracts from natural and genetically modified soybean
Authors: Gervazieva V B , Samoylikov P V , Berzhets V M , Pishchulina L A , Mazurina S A , Dudorova A A
Published: June 2020

Background. The wide spread of soybeans both natural and genetically modified (GM) in agriculture and food industry arises a question about the safety of its use, as soy is the most common food allergen among leguminous plants. Meanwhile, there are no registered domestic diagnostic allergens from soybeans in Russia. Objective. The aim of this study was to obtain allergenic extracts from natural and GM soybeans resistant to the herbicide «Roundup» and evaluate their biochemical and allergenic properties. Methods. Soybean extracts were obtained by the Evans-Kok method. The amount of protein nitrogen was determined by the Nessler method. The protein composition of the soybean was determined by the SDSPAGE. Specific activity was assessed in the reaction of NDTK. Allergenic activity was assessed in ELISA according to the sIgE levels to soy in the sera of patients with food allergy. Results. The protein fractions corresponding to known allergens weare revealed by SDS-PAGE in the samples of extracts: natural soybeans - Gly m 3, Gly m 5, and Gly m 6, while GM soybeans - Gly m Bd 30k. In addition to those proteins, in both extracts the 20 kD protein was clearly detected, which can correspond to the inhibitor of trypsin Kunitsa (Hor v 1, CMb, BDR). Allergenic soybean extracts bind sIgE and sIgG in the sera of patients with allergies. Conclusion. The obtained data confirm the high allergenic potential of extracts from natural soybeans, whereas the allergenic activity of GM soybeans extracts is reduced.
Cross-sectional study of allergen sensitization in pre-school children living in urban environment of the Altai region with asthma and/or rhinitis
Authors: Shakhova N V , Kamaltynova E M , Lobanov Y Ph , Kashinskaya T S
Published: June 2020

Sensitization spectrum in pre-school children with asthma and/or rhinitis remains unclear. Objective. Our aim was to estimate the allergen sensitization in preschool children living in urban environment of the Altai region with asthma and/or rhinitis. Materials and methods. A cross-sectional survey was performed in 182 children aged from 3 to 6 years suffering from asthma and/or rhinitis in 5 cities of Altai region. Asthma was diagnosed according to the Global Initiative for Asthma guidelines, allergic rhinitis was diagnosed according to the ARIA guidelines. ImmunoCAP and skin prick test were used to assess sensitization spectrum. Results. Among the 182 patients 144 (79,1%) had sensitization at least to one allergen. Sensitization to one allergen was detected in 38.5% of children, sensitization to 2 or more allergens - in 40,6%. Sensitization to Dermatophagoides pteronyssinus was detected in 46,7%, to birch pollen - in 37,3%, to cat epithelium - in 27,4% of patients. Sensitization to food allergens was detected only in 10,4%. Conclusion. The study revealed a high frequency of sensitization to 2 or more allergens - in 79,1% of 3-6 years old children with asthma and/or rhinitis . Most often, preschool children with asthma and/or rhinitis are sensitized to 3 inhaled allergens - to Dermatophagoides pteronyssinus (46,7%), to birch pollen (37,3%) and to cat epithelium (27,4%).
Clinical efficacy of modern emollients in atopic dermatitis: case report
Authors: Smolnikov E V , Litovkina A O , Elisyutina O G , Fedenko E S
Published: June 2020

Atopic dermatitis is the common chronic inflammatory disorder, characterized by skin irritation, itch, often accompanied by respiratory allergy symptoms - allergic rhinitis and bronchial asthma. AD prevalence varies between 15-30% in children and 2-14% in adults in industrialized countries. The pathophysiology of atopic dermatitis is complex encompassing genetic predisposition to allergy, dysregulation of innate and adaptive immunity and environmental risk factors. Recent genetic and molecular research has focused interest on skin barrier function and it’s role in AD pathogenesis. It has been established that disruption of the epidermal barrier leads to increased permeability of the epidermis, pathological inflammation in the skin, and percutaneous sensitization to allergens. Thus, most novel treatment strategies seek to target immune therapy, repair of epidermal barrier and prevention of sensibilization and atopic march. The article is devoted to skin barrier function disruption in AD and beneficial role of emollients in skin care; clinical case is presented.
Monoclonal antibodies in the treatment of bronchial asthma
Authors: Ilina N I , Kurbacheva O M
Published: June 2020

The article discusses different phenotypes of heterogeneous bronchial asthma (BA), methods of identification of patients with severe bronchial asthma, based on clinical characteristics, biological and genetic markers. Definition of phenotypes/ endotypes of BA contributes to better understanding of the nature of the disease and is feasible for development of an individual approach to therapy, because some types of BA may differ in resistance response to the standard treatment. The article gives an overview of modern research focused on the use of monoclonal antibodies in the treatment of BA. It discusses the algorithm of selection of patients with severe BA for prescribing of biological therapy.
Allergy to egg whites: diagnosis, symptoms (clinical features), prognosis
Authors: Kudryavtseva A V , Boguslavskaya Y A
Published: June 2020

Allergic reactions to hen’s egg are rather a common problem, especially in infants. Hen’s eggs contain a few protein components which may serve as food allergens. They are 4 egg-white proteins: ovomucoid (Gal d 1, 11%), ovalbumin (Gal d 2, 54%), ovotransferrin (Gal d 3, 12%), lysozyme (Gal d 4, 3,4%) and one egg-yolk protein - alpha-livetin (Gal d 5). Ovomucoid (OVM) is the dominant allergen in hen’s egg. The allergenicity of egg whites depends mostly on their resistance to heat and digestive enzymes. A skin prick test size of 5 mm in children younger than 2 years old and 7 mm in children older than 2 years had a positive predicative value (PPV) of 100%. However, patient questioning and skin testing cannot be the only proof of food allergy. There exists a positive correlation between the growing levels of eggs-pecific IgE and the probability of allergic symptoms occurrence. Testing for sensitization to different hen’s egg proteins (molecular diagnostic) may assist in marking off allergy reaction to raw eggs from that one to heat-treated eggs. Questionable cases call for carrying out challenge tests which are not certified in Russia. The recent studies have demonstrated the safety of measles vaccination in children with proven eggwhite allergy. Currently, oral, sublingual and epicutaneous immunotherapy for food allergy to egg-whites has been extensively investigated in clinical trials.
Features of fungal sensitization in patients with asthma and cystic fibrosis: the results of a prospective study
Authors: Kozlova Y I , Frolova E V , Borzova Y V , Sobolev A V , Burygina E V , Aak O V , Nikitin O A , Kuznetsov V D , Klimko N N
Published: June 2020

Background. To estimate the frequency of fungal sensitization and allergic bronchopulmonary aspergillosis in patients with asthma or cystic fibrosis. Methods. The study included 205 patients with asthma and 190 patients with cystic fibrosis. For detection of fungal sensitization specific IgE antibodies in the blood serum with «AllergoELISA-specific IgE» test system and biotinylated fungal allergens were determined. Mycological examination included microscopy and cultural study of respiratory biomaterials. According to the indications, a CAT scan of the chest was performed. Results. The incidence of fungal sensitization in patients with asthma was 35,6%, CI [29,1%; 42,6%], in patients with cystic fibrosis - 56,8% [49,5%; 64%]. In patients with severe asthma the main fungal allergens were Alternaria spp. (70%) and Aspergillus spp. (60%); in patients with cystic fibrosis: Candida spp. - 73%, Alternaria spp. - 34%, Aspergillus spp. - 27%. The incidence of allergic bronchopulmonary aspergillosis (ABPA) in patients with asthma was 5,3%, in patients with cystic fibrosis - 5,7%. Conclusion Early detection of ABPA in patients with asthma and cystic fibrosis is very important as it changes the therapeutic measures of patients’ management and prevents progression of bronchiectasis and respiratory failure. Determination of specific Aspergillus spp. IgE antibodies in vitro is a necessary stage of diagnosis of ABPA in patients at risk.
What is аsthma-COPD Overlap syndrome (ACOS), diagnostics and treatment
Authors: Fedoseev G B , Trofimov V I , Negrutsa K V , Timchik V G , Golubeva V I , Aleksandrin V A , Razumovskaya T S , Rabik U D , Kryakunov K N
Published: June 2020

175 patients were examined: 78 patients with bronchial asthma (BA), 39 with Asthma-COPD Overlap Syndrome (ACOS), 38 with chronic obstructive pulmonary disease (COPD) and 20 healthy individuals. A general clinical and laboratory examination was conducted, α1-antitrypsin (AAT), IgG and IgA to four bacterial antigens were determined, and pulmonary function test was studied. The clinical and spirometry data (characterizing the ACOS) were received. Negative association of AAT with respiratory function parameters in patients with ACOS, high levels of IgG antibodies to bacterial antigens and the lack of these connections in patients with BA and COPD allows us to consider ACOS to be independent nosological form related with microbial inflammation and marked by the AAT.
The role of ß2-adrenergic receptor gene polymorphisms in the pharmacological response to bronchial asthma therapy
Authors: Pavlova K S , Mdinaradze D S , Kofiadi I A , Kurbacheva O M
Published: June 2020

This article represents an abstract and analytical review of studies devoted to the polymorphisms of β2-adrenergic receptor gene (ADRB2) and their associations with the degree of severity of bronchial asthma (BA) and response to standard pharmacotherapy. The results of the analysis showed a high heterogeneity of the data obtained, which is aggravated by different goals, objectives and study design. If the polymorphism of ADRB2 gene affects the expression of this receptor, it is possible that these asthma patients will show a low response to SABA / LABA; short- and long-acting anticholinergics will be preferred as bronchodilators. It is impossible to make a unique conclusion about the association between the polymorphisms of ADRB2 gene and the SABA / LABA responsiveness according to the results of analyzed publications. Data of the prevalence of homozygous alleles and studied associations among different populations are contradictory. Achievement of the asthma symptoms control is the main goal of asthma therapy. At the same time it’s impossible for a limited number of asthma patients in spite of the provision of current effective pharmacological resources. These aspects necessitate the research of the molecular-genetic mechanisms of pathogenesis in order to improve diagnostics and individual approach to the pharmacotherapy choice for patients with poor asthma control.
Target immunotherapy of atopic dermatitis
Authors: Elisyutina O G
Published: June 2020

The data about novel immunopathogenetic mechanisms of AD that may be a therapeutic targets for the new immune therapy are presented in the review. The current results of modern clinical trials of targeted biological agents in AD are summarized.
Supporting a Physical Self-Access Centre with a Virtual Presence
Authors: Rubesch Troy , Barrs Keith
Published: June 2020

This article describes the motivation and reasoning behind an ongoing project to create an online presence of a Self-Access Center (SAC). The project involves the selection and integration of a number of technologies which work to together to supplement the physical SAC. The authors argue that such projects have value both for the institutions which host them, and also for the learners they serve, such as support of individualized and independent learning, promotion of the SAC, and hosting and archiving resources. Establishing an online presence allows learners much greater freedom in when, where, what, and how they study.
Analisis motivasi belajar siswa pada pembelajaran IPA di SDN 16/ii Sepunggur
Authors: Nugroho Gusti
Published: June 2020

Purpose of the study: motivasi belajar siswa erupakan salah satu unsur yang sangat penting. penelitian ini bertujuan untuk menganalisis motivasi belajar siswa di kelas 4 SDN 16/II Sepunggur Methodology: Desain penelitian yang digunakan oleh peneliti adalah penelitian kuantitatif yang menggunakan desain penelitian adalah penelitian survei. Main Findings: Hasil data pengamatan siswa yang temasuk dalam kategori sangat baik sebesar 20%, siswa dalam kategori baik sebesar 52% tau sebanyak 13 siswa, siswa yang termasuk dalam kategori kurang baik sebesar 16% dan siswa yang termasuk dalam kategori tidak baik sebesar 8%. siswa laki-laki yang termasuk dalam kategori sangat baik sebesar 16,66%, kategori baik sebesar 58,33%, yang termasuk dalam kategori kurang baik sebesar 16,66%, dan kategori tidak baik sebesar 8,33%. Sedangkan pada siswa perempuan yang termasuk dalam kategori sangat baik sebesar 23%, termasuk dalam kategori baik sebesar 46%, kategori kurang baik sebesar 15,38% dan yang termasuk dalam kategori tidak baik sebesar 15,38%. Novelty/Originality of this study: keterbaruan dalam penelitian ini yaitu menganalis sikap motivasi siswa pada pembelajaran IPA yang ada di SDN 16/II Sepunggur.
A New trend in understanding students' interest in learning science: microetnography
Authors: Maguil Carlo Jaime Mendoza , Ismawan Prasetia Devi
Published: June 2020

Purpose of the study: Describe the trend of shifting student interest in learning science in middle school.

Methodology: This study uses descriptive qualitative and descriptive inquiry approaches in analyzing new trends of student interest in learning science in middle school.

Main Findings: The findings can be concluded that the shift in interest is influenced by technology.

Applications of this study: The results of this study will be useful for the pedagogical realm of teachers in teaching science.

Novelty/Originality of this study: The novelty of this research interest in learning science has changed dramatically with the ease of internet access
Kedisiplinan siswa terhadap objek mata pelajaran IPA di SMP Kabupaten Muaro Jambi
Authors: Kurniawan Nugroho , Nurlaili Nurlaili
Published: June 2020

Purpose of the study: Disiplin merupakan suatu siklus perilaku kebiasaan yang konsisten dan berulang-ulang untuk melakukan, menanggapi atau responsif terhadap objek. disiplin ini akan berdampak pada karakter individu. Sedangkan disiplin terhadap IPA diartikan sebagai kebiasaan yang menjadi karakter siswa dalam menanggapi objek IPA dan sifatnya cenderung tetap. Penelitian ini bertujuan untuk melakukan analisis bagaimana kedisiplinan siswa terhadap IPA

Methodology: Penelitian ini menganalisis 187 sampel Siswa SMP Negeri di Kab. Muaro Jambi. Dan dilaksanakan dengan metode survey. Hasil data penelitian berasal angket disiplin siswa terhadap IPA.

Main Findings: Hasil penelitian didasarkan berdasarkan hasil indikator disiplin yang diukur berikut ini: (1) disiplin masuk sekolah berkategori sangat baik dengan 69% (129 siswa), (2) disiplin mengikuti pelajaran IPA berkategori displin sangat baik dengan 35,8% (67 siswa), dan (3) disiplin mengerjakan tugas IPA berkategori baik dengan 46% (86 siswa). Berdasarkan Hasil data tersebut dapat disimmpulkan bahwa disiplin siswa terhadap IPA menunjukkan hasil disiplin positif dengan kategori sangat baik.

Novelty/Originality of this study: keterbaruan dalam penelitian ini yaitu menganalis sikap disiplin siswa pada pembelajaran IPA .
Analisis sikap siswa pada pembelajaran IPA di SDN 124/VIII Sidorejo Kabupaten Tebo
Authors: Paino Paino , Desmawan Wisnu
Published: June 2020

Purpose of the study: Sikap merupakan salah satu instrumen penting yang harus dimiliki oleh seorang siswa. Penelitian ini bertujuan untuk mengetahui siskap siswa SDN 124/VIII Sidorejo pada pembelajaran IPA.

Methodology: Penelitian ini mengunakan jenis penelitian kuantitatif jenis survey dengan teknik pengambilan data berupa angket dan wawancara yang diolah menggunakan SPSS 21 dengan teknik statistik deskriptif. 

Main Findings: Hasil temuan penelitian ini yaitu dari 125 siswa yang kemudian hasilnya di olah dan dimasukkan ke dalam 5 kategori, sikap IPA siswa di SDN 124/VIII Sidorejo terdapat kecenderungan atau lebih dominan ke dalam kategori baik dengan persentase sebesar 50%. Sedangkan pada kategori sangat baik sebesar 10%, pada kategori cukup baik sebesar 25%, kategori tidak baik sebesar 10%  dan kategori sangat tidak baik sebesar 5%. 

Novelty/Originality of this study: keterbaruan dalam penelitian ini yaitu untuk menganaslisi sikap IPA siswa dengan indikator implikasi sosial IPA di SDN 124/VIII Sidorejo.
The Important of Employee Retention Programs towards Bank Performance in East Coast, Malaysia
Authors: Derani Nor Emmy Shuhada , Ghani Fadhilah Bte. Abdul
Published: June 2020

The purpose of this study is to explore the important of organizations’ retention programs towards improving firm performance in banking sector. Almost every day, banking sector in Malaysia received resignation letter from its employees. It’s either from permanent or contract basis employees. An organization underestimate this matter and just take it for granted and it resulted bank performance decreased as well as increasing in spending for new hiring. This study has been conducted by distributing questionnaire to commercial and conventional banks in East Coast, Malaysia. The findings displayed the training and development, employee compensation, communication in workplace and value in teamwork is crucial to retain employees as well as to improve bank performance in Malaysia. Result from this study will help management especially HR department to look into retention programs seriously for the purpose of retaining its staff and expertise. For future research, it has been recommended to explore new industry such as manufacturing, hotel industry, retail as well as telecommunication company due to these industries nowadays shows high rate of turnover.
Awareness towards Accountancy as a Profession
Authors: Remali Azrinawati Mohd , Apalasamy Kirrthini , Jegadeesvaran Logalatha , Laxmanarao Mahasri , Morgan Rogany
Published: June 2020

This study investigates the awareness of secondary school students towards accountancy as a profession due to the shortage of qualified accountants required by Malaysia government in the era 2020. A lack of information/misinformation about what accounting is and what accountants do which caused the school leavers having less awareness regarding the accountancy profession. There are four factors that been tested; namely as gender, personal interest, level of difficulties for accounting subject as well as knowledge and career prospects. The study focuses on secondary school students and 270 students who taking Principle of Account subject at Segamat, Johor and Muadzam Shah, Pahang secondary. The analysis of data utilizes the statistical package of SPSS. The result revealed that personal interests as well as knowledge and career prospects have significant relationship with the awareness of students towards accountancy as a profession. Meanwhile gender and level of difficulties for accounting subject do not have significance difference/relationship with the awareness of students towards accountancy as a profession.
Probing the value platform of Byzantine philosophy and its message for a modern European value orientation
Authors: Pružinec Tomáš
Published: June 2020

The proposed study presents the problems of the value platform of Byzantine philosophy. The article begins with a controversy about the very possibility of opening this topic. In general, attention is focused on the limits and difficulties of searching for the value platform of Byzantine philosophy and at the same time on searching for opportunities to discover it. Attention is also drawn to the field of culture and semantics of the conceptual apparatus. At the forefront is a reflection on the philosophical expression of the cosmos, as well as on what the terms "synergetic" and "ecumenical" are. At the end of the article, some assumptions are made about the importance of the value platform of the Byzantine philosophy for the modern European value orientation and its direction.
Emotions and Dispositional Predicates
Authors: Sinitskiy Dmitriy
Published: June 2020

Affective computing and affective calculus are currently one of the rapidly developing areas of interdisciplinary research. The aim of the article is to examine the approach to building a formalized theory of emotions developed by the Dutch logicians B. Steunebrink, M. Dastani and J.-J. Ch. Meyer, as well as the analysis of this theory for the use of dispositional predicates in it. Reduction definitions for observation predicates and dispositional predicates in the analyzed theory of emotions are constructed in terms of emotion triggers and emotion experience predicates, which are then reduced to expressions of the language of epistemic and dynamic logics.
Percepción social del riesgo hídrico: análisis de los significados atribuidos a los eventos de anegamientos en el barrio Villa Talleres, ciudad de Bahía Blanca (provincia de Buenos Aires, Argentina)
Authors: Mastrandrea Aldana
Published: June 2020

La Geografía de la Percepción y el abordaje cultural constituyen enfoques enriquecedores de análisis en el reconocimiento de los significados que los habitantes del espacio urbano les asignan a los problemas que enfrentan en su vida cotidiana. En la ciudad de Bahía Blanca, el barrio Villa Talleres manifiesta inconvenientes derivados de su vulnerabilidad física, aspectos que se evidencian en la ocurrencia de inundaciones y anegamientos. En la presente investigación, de carácter cualitativa, se realizan entrevistas semiestructuradas a los vecinos del barrio y se recopila información acerca de las experiencias vividas por los habitantes de la ciudad en el periodismo televisivo, digital y en las redes sociales. A modo de resultados preliminares, se advierte que la percepción social que los vecinos elaboran del barrio responde a una imagen de abandono relacionada con los problemas que enfrentan, pero al mismo tiempo, caracterizada por una gran cohesión social derivada de las actividades comunitarias que allí se desarrollan.
Torsion of inhomogeneous rods made of an ideal rigid plastic material under a linearized plasticity condition
Authors: Миронов Борис Гурьевич , Миронов Юрий Борисович
Published: June 2020

В работе исследовано кручение неоднородных стержней из идеального жесткопластического материала. Получены интегралы, определяющие напряженное и деформированное состояния стержня при линеаризованном условии пластичности. Определено предельное состояние призматического стержня при кручении, найдены линии разрыва напряжений.

The torsion of inhomogeneous rods made of an ideal rigid-plastic material is studied. Integrals are obtained that determine the stress and strain States of the rod under the linearized plasticity condition. The limit state of the prismatic rod during torsion is determined, and the stress break lines are found