bluuebunny/crossref_metadata_2025 huggingface dataset:
Marginal Ulcer Perforation after One Anastomosis Gastric Bypass: Surgical Treatment and Two-Year Outcomes
Authors: Abu-Abeid Adam , Litmanovich Adi , Yuval Jonathan Benjamin , Tome Jawad , Keidar Andrei , Eldar Shai Meron
Published: May 2024

Background: Marginal ulcer (MU) perforation is a chronic complication after One-anastomosis Gastric Bypass (OAGB). This study’s purpose was to analyze patients undergoing OAGB revision due to MU perforation and describe the two-year outcomes. Methods: A retrospective analysis of a database in a single-tertiary hospital. All patients undergoing surgical revision due to MU perforation were included. Results: During the study period, 22 patients underwent OAGB revision due to MU perforation. The rate of MU perforation was 0.98%. The median age was 48 years and there were 13 men (59%). The median time from OAGB to MU perforation was 19 months with a median total weight loss of 31.5%. Nine patients (41%) were smokers. Omental patch (±primary closure) was performed in 19 patients (86%) and three patients (14%) underwent conversion to Roux-en-Y gastric bypass (RYGB). At a median follow-up of 48 months, three patients (14%) had recurrent MU diagnosis, of which one had a recurrent MU perforation. Four patients (18%) underwent conversion to RYGB during follow-up. Conclusions: MU perforation is a chronic complication after OAGB. In this cohort, most patients were men and likely to be smokers. Omental patch was effective in most cases. Recurrent MU rates at two years follow-up were acceptable.
Depression and Eye Disease—A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications
Authors: Tang Wymann Shao Wen , Lau Nicole Xer Min , Krishnan Muthuramalingam Naveen , Chin You Chuen , Ho Cyrus Su Hui
Published: May 2024

Background: Depression has been shown to be associated with eye diseases, including dry eye disease (DED), cataracts, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). This narrative review explores potential pathophysiological connections between depression and eye disease, as well as its potential correlations with ocular parameters. Methods: A literature search was conducted in August 2022 in PUBMED, EMBASE, and PsycINFO. Published articles related to the subject were consolidated and classified according to respective eye diseases and pathophysiological mechanisms. Results: The literature reviewed suggests that common pathophysiological states like inflammation and neurodegeneration may contribute to both depression and certain eye diseases, while somatic symptoms and altered physiology, such as disruptions in circadian rhythm due to eye diseases, can also influence patients’ mood states. Grounded in the shared embryological, anatomical, and physiological features between the eye and the brain, depression is also correlated to changes observed in non-invasive ophthalmological imaging modalities, such as changes in the retinal nerve fibre layer and retinal microvasculature. Conclusions: There is substantial evidence of a close association between depression and eye diseases. Understanding the underlying concepts can inform further research on treatment options and monitoring of depression based on ocular parameters.
Complications of Prostate Cancer Treatment: Open Issues
Authors: Angulo Javier C.
Published: May 2024

Unfortunately, prostate cancer treatment is not free of complications [...]
Elasticity Modification of Biomaterials Used in 3D Printing with an Elastin–Silk-like Recombinant Protein
Authors: Cecuda-Adamczewska Violetta , Romanik-Chruścielewska Agnieszka , Kosowska Katarzyna , Sokołowska Iwona , Łukasiewicz Natalia , Korycka Paulina , Florys-Jankowska Katarzyna , Zakrzewska Agnieszka , Wszoła Michał , Klak Marta
Published: May 2024

The recombinant structural protein described in this study was designed based on sequences derived from elastin and silk. Silk–elastin hybrid copolymers are characterized by high solubility while maintaining high product flexibility. The phase transition temperature from aqueous solution to hydrogel, as well as other physicochemical and mechanical properties of such particles, can differ significantly depending on the number of sequence repeats. We present a preliminary characterization of the EJ17zipR protein obtained in high yield in a prokaryotic expression system and efficiently purified via a multistep process. Its addition significantly improves biomaterial’s rheological and mechanical properties, especially elasticity. As a result, EJ17zipR appears to be a promising component for bioinks designed to print spatially complex structures that positively influence both shape retention and the internal transport of body fluids. The results of biological studies indicate that the addition of the studied protein creates a favorable microenvironment for cell adhesion, growth, and migration.
FSN-YOLO: Nearshore Vessel Detection via Fusing Receptive-Field Attention and Lightweight Network
Authors: Du Na , Feng Qing , Liu Qichuang , Li Hui , Guo Shikai
Published: May 2024

Vessel detection is critical for ensuring maritime transportation and navigational safety, creating a pressing need for detection methodologies that are more efficient, precise, and intelligent in the maritime domain. Nonetheless, accurately detecting vessels across multiple scales remains challenging due to the diversity in vessel types and locations, similarities in ship hull shapes, and disturbances from complex environmental conditions. To address these issues, we introduce an innovative FSN-YOLO framework that utilizes enhanced YOLOv8 with multi-layer attention feature fusion. Specifically, FSN-YOLO employs the backbone structure of FasterNet, enriching feature representations through super-resolution processing with a lightweight Convolutional Neural Network (CNN), thereby achieving a balance between processing speed and model size without compromising accuracy. Furthermore, FSN-YOLO uses the Receptive-Field Attention (RFA) mechanism to adaptively fine-tune the feature responses between channels, significantly boosting the network’s capacity to capture critical information and, in turn, improve the model’s overall performance and enrich the discriminative feature representation of ships. Experimental validation on the Seaship7000 dataset showed that, compared to the baseline YOLOv8l approach, FSN-YOLO considerably increased accuracy, recall rates, and mAP@0.5:0.95 by absolute margins of 0.82%, 1.54%, and 1.56%, respectively, positioning it at the forefront of current state-of-the-art models.
Correction: Boorboori, M.R.; Zhang, H.-Y. Arbuscular Mycorrhizal Fungi Are an Influential Factor in Improving the Phytoremediation of Arsenic, Cadmium, Lead, and Chromium. J. Fungi 2022, 8, 176
Authors: Boorboori Mohammad Reza , Zhang Hai-Yang
Published: May 2024

In the original publication [...]
Circulating microRNAs and DNA Methylation as Regulators of Direct Oral Anticoagulant Response in Atrial Fibrillation and Key Elements for the Identification of the Mechanism of Action (miR-CRAFT): Study Design and Patient Enrolment
Authors: Ragia Georgia , Thomopoulos Thomas , Chalikias Georgios , Trikas Athanasios , Tziakas Dimitrios N. , Manolopoulos Vangelis G.
Published: May 2024

Direct oral anticoagulants (DOACs) are the standard treatment for thromboembolic protection in atrial fibrillation (AF) patients. Epigenetic modifications, such as DNA methylation and microRNAs, have emerged as potential biomarkers of AF. The epigenetics of DOACs is still an understudied field. It is largely unknown whether epigenetic modifications interfere with DOAC response or whether DOAC treatment induces epigenetic modifications. To fill this gap, we started the miR-CRAFT (Circulating microRNAs and DNA methylation as regulators of Direct Oral Anticoagulant Response in Atrial Fibrillation) research study. In miR-CRAFT, we follow, over time, changes in DNA methylation and microRNAs expression in naïve AF patients starting DOAC treatment. The ultimate goal of miR-CRAFT is to identify the molecular pathways epigenetically affected by DOACs, beyond the coagulation cascade, that are potentially mediating DOAC pleiotropic actions and to propose specific microRNAs as novel circulating biomarkers for DOAC therapy monitoring. We herein describe the study design and briefly present the progress in participant enrolment.
ChatGPT as a New Tool to Select a Biological for Chronic Rhino Sinusitis with Polyps, “Caution Advised” or “Distant Reality”?
Authors: Sireci Federico , Lorusso Francesco , Immordino Angelo , Centineo Manuela , Gerardi Ignazio , Patti Gaetano , Rusignuolo Simona , Manzella Riccardo , Gallina Salvatore , Dispenza Francesco
Published: May 2024

ChatGPT is an advanced language model developed by OpenAI, designed for natural language understanding and generation. It employs deep learning technology to comprehend and generate human-like text, making it versatile for various applications. The aim of this study is to assess the alignment between the Rhinology Board’s indications and ChatGPT’s recommendations for treating patients with chronic rhinosinusitis with nasal polyps (CRSwNP) using biologic therapy. An observational cohort study involving 72 patients was conducted to evaluate various parameters of type 2 inflammation and assess the concordance in therapy choices between ChatGPT and the Rhinology Board. The observed results highlight the potential of Chat-GPT in guiding optimal biological therapy selection, with a concordance percentage = 68% and a Kappa coefficient = 0.69 (CI95% [0.50; 0.75]). In particular, the concordance was, respectively, 79.6% for dupilumab, 20% for mepolizumab, and 0% for omalizumab. This research represents a significant advancement in managing CRSwNP, addressing a condition lacking robust biomarkers. It provides valuable insights into the potential of AI, specifically ChatGPT, to assist otolaryngologists in determining the optimal biological therapy for personalized patient care. Our results demonstrate the need to implement the use of this tool to effectively aid clinicians.
Effects of Ownership Structure on Intellectual Capital: Evidence from Publicly Listed Banks in Bangladesh
Authors: Hossain Syed Zabid , Rana Md. Sohel
Published: May 2024

This study explored the impacts of ownership structure (OS) on intellectual capital (IC) and its components. Data were gathered from 31 Dhaka Stock Exchange-listed banks for five years, from 2017 to 2021, consisting of 155 observations as balanced panel data. The study used the modified value-added intellectual coefficient (MVAIC) model to track the IC efficiency. The robust fixed effects model was employed for regression analysis to test the hypotheses. The research found that sponsor director ownership is negatively associated with the MVAIC, human capital efficiency (HCE), and structural capital efficiency (SCE) but positively with relational capital efficiency (RCE). High institutional and public ownership are positively linked with SCE but negatively with RCE. Foreign ownership is only positively associated with banks’ MVAIC and HCE. The regression results showed that high institutional ownership (IO) significantly enhanced the MVAIC and HCE. Foreign and public ownership positively influenced banks’ MVAIC, HCE, and capital employed efficiency (CEE) but negatively impacted RCE. The findings of this study will help banks’ policymakers with ownership mixes for the optimum utilization of banks’ resources. Management may assess IC’s efficiency level for proper supervision and use of knowledge resources to boost bank profitability. Also, the findings will help investors make prudent investment decisions. This is the first study to focus on OS and IC with diverse elements in Southeast Asia, especially Bangladesh, an emerging market.
Redefining Boundaries in the Metaverse: Navigating the Challenges of Virtual Harm and User Safety
Authors: Chawki Mohamed , Basu Subhajit , Choi Kyung-Shick
Published: May 2024

This paper analyses sexual crimes within the Metaverse to develop an effective legal framework. The aim is to enhance safety in virtual realities, ensuring the Metaverse remains a secure, respectful, and liberating environment for all users. As the Metaverse continues to evolve, merging augmented physical reality with digital existence, it introduces new opportunities for socialisation, commerce, education, and entertainment. However, this digital realm also faces significant challenges, particularly the increase in sexual violence. This article evaluates the development of the Metaverse and its impact on sexual offences. It provides an overview of the Metaverse, followed by an in-depth exploration of the nature of sexual violence in this virtual space, its effects on victims, and the resulting legal and ethical issues. Additionally, this article examines the complexities of combating sexual violence within the Metaverse, reviewing the legal frameworks in various jurisdictions, including the United States, the European Union, the United Kingdom, and South Korea. These examinations reveal a range of legal viewpoints and possible solutions. This article outlines a proposed legal framework, highlighting key strategic areas for mitigating sexual violence in the Metaverse. The primary objective is to enrich the discourse on the Metaverse, pushing for strong, flexible, and holistic legal measures. Through this research, we aim to contribute to the creation of protective mechanisms against sexual violence in these emerging virtual landscapes.
Relationships and Within-Group Differences in Physical Attributes and Golf Performance in Elite Amateur Female Players
Authors: Robinson Luke , Murray Andrew , Coughlan Daniel , Mountjoy Margo , Wells Jack , Hembrough Rebecca , Glover Danny , Scott Fiona , Turner Anthony , Bishop Chris
Published: May 2024

The aim of the present study was to examine the association between a comprehensive physical testing battery and measures of golf performance in elite female amateur players. Nineteen category one (handicap ≤ 5) or better golfers (age: 16.26 ± 1.28 years, height: 166.26 ± 3.62 cm, mass: 64.04 ± 11.27 kg, wingspan: 146.53 ± 15.59 cm, handicap: +1.45 ± 0.7) volunteered to participate in this investigation. All golfers attended a single 90 min testing session where golf shot data (clubhead speed [CHS], ball speed, carry distance, and smash factor) were measured with a Trackman 4 launch monitor and a battery of physical assessments were carried out. These included anthropometric data and assessments for seated thoracic rotation, the isometric mid-thigh pull (IMTP), isometric bench press, countermovement jump (CMJ), and seated medicine ball throws for distance. Pearson’s r correlations showed CHS was the golf metric that most commonly demonstrated large associations with physical testing data, most notably with force at 100 ms during the isometric bench press (r = 0.70). Median split analysis was also conducted for the IMTP (force at 200 ms), isometric bench press (force at 100 ms), and CMJ (positive impulse). The results showed that players who produced more force at 200 ms during the IMTP exhibited a greater CHS (g = 1.13), ball speed (g = 0.90), and carry distance (g = 1.01). In addition, players with a greater positive impulse during the CMJ showed a greater ball speed (g = 0.93), carry distance (g = 1.29), and smash factor (g = 1.27). Collectively, these results highlight the relevance of explosive force production capabilities in both the lower and upper body for female golfers. This information can be used by practitioners to better target key physical attributes during testing and training of female players.
Defoaming and Toughening Effects of Highly Dispersed Graphene Oxide Modified by Amphoteric Polycarboxylate Superplasticizer on Oil Well Cement
Authors: Zeng Min , Xing Yubing , Xie Yongxu , Xu Dawei , Miao Xia , Guo Jintang
Published: May 2024

The aggregation of graphene oxide (GO) during the hydration process limits its wide application. Polymer superplasticizers have been used to improve the dispersion state of GO due to their adsorption and site-blocking effects, though the formation of a large amount of foam during the mixing process weakens the mechanical properties of cement. A highly dispersed amphoteric polycarboxylate superplasticizer-stabilized graphene oxide (APC/GO) toughening agent was prepared by electrostatic self-assembly. Results demonstrate that the APC/GO composite dispersed well in a cement pore solution due to the steric effect offered by the APC. Additionally, the well-dispersed GO acted as an antifoaming agent in the cement since GO nanosheets can be absorbed at the air–liquid interface of APC foam via electrostatic interactions and eliminate the air-entraining effect. The well-dispersed APC/GO sheets promoted cement hydration and further refined its pore structure owing to the nucleation effect. The flexural and compressive strength of the cement containing the APC/GO composite were enhanced by 21.51% and 18.58%, respectively, after a 7-day hydration process compared with a blank sample. The improved hydration degree, highly polymerized C-S-H gel, and refined pore structure provided enhanced mechanical properties.
TPMS Microarchitectures for Vertical Bone Augmentation and Osteoconduction: An In Vivo Study
Authors: Maevskaia Ekaterina , Ghayor Chafik , Bhattacharya Indranil , Guerrero Julien , Weber Franz E.
Published: May 2024

Triply periodic minimal surface microarchitectures (TPMS) were developed by mathematicians and evolved in all kingdoms of living organisms. Renowned for their lightweight yet robust attributes, TPMS structures find application in diverse fields, such as the construction of satellites, aircrafts, and electric vehicles. Moreover, these microarchitectures, despite their intricate geometric patterns, demonstrate potential for application as bone substitutes, despite the inherent gothic style of natural bone microarchitecture. Here, we produced three TPMS microarchitectures, D-diamond, G-gyroid, and P-primitive, by 3D printing from hydroxyapatite. We explored their mechanical characterization and, further, implanted them to study their bone augmentation and osteoconduction potential. In terms of strength, the D-diamond and G-gyroid performed significantly better than the P-primitive. In a calvarial defect model and a calvarial bone augmentation model, where osteoconduction is determined as the extent of bony bridging of the defect and bone augmentation as the maximal vertical bone ingrowth, the G-gyroid performed significantly better than the P-primitive. No significant difference in performance was observed between the G-gyroid and D-diamond. Since, in real life, the treatment of bone deficiencies in patients comprises elements of defect bridging and bone augmentation, ceramic scaffolds with D-diamond and G-gyroid microarchitectures appear as the best choice for a TPMS-based scaffold in bone tissue engineering.
Fabrication of Ceramic Microchannels with Periodic Corrugated Microstructures as Catalyst Support for Hydrogen Production via Diamond Wire Sawing
Authors: Li Xinying , Gao Chao , Yuan Ding , Qin Yuanbao , Fu Dongbi , Jiang Xiyang , Zhou Wei
Published: May 2024

Hydrogen energy is the clean energy with the most potential in the 21st century. The microchannel reactor for methanol steam reforming (MSR) is one of the effective ways to obtain hydrogen. Ceramic materials have the advantages of high temperature resistance, corrosion resistance, and high mechanical strength, and are ideal materials for preparing the catalyst support in microchannel reactors. However, the structure of ceramic materials is hard and brittle, and the feature size of microchannel is generally not more than 1 mm, which is difficult to process using traditional processing methods. Diamond wire saw processing technology is mainly used in the slicing of hard and brittle materials such as sapphire and silicon. In this paper, a microchannel with a periodic corrugated microstructure was fabricated on a ceramic plate using diamond wire sawing, and then as a catalyst support when used in a microreactor for MSR hydrogen production. The effects of wire speed and feed speed on the amplitude and period size of the periodic corrugated microstructure were studied using a single-factor experiment. The microchannel surface morphology was observed via SEM and a 3D confocal laser microscope under different processing parameters. The microchannel samples obtained under different processing parameters were supported by a multiple impregnation method. The loading strength of the catalyst was tested via a strong wind purge experiment. The experimental results show that the periodic corrugated microstructure can significantly enhance the load strength of the catalyst. The microchannel catalyst support with the periodic corrugated microstructure was put into the microreactor for a hydrogen production experiment, and a good hydrogen production effect was obtained. The experimental results have a positive guiding effect on promoting ceramic materials as the microchannel catalyst support for the development of hydrogen energy.
Quasi-Static Penetration Properties of 3D-Printed Composite Plates
Authors: Baruscotti Axel , Borgianni Yuri , Concli Franco
Published: May 2024

This work investigated the impact and piercing load resistance (energy absorption capabilities) of 3D-printed composites plates manufactured by means of the Fused-Filament-Fabrication (FFF) technique. Two sets of reinforced composite plates were produced. The first set of plates was printed with short-carbon-fiber-reinforced polyamide-12, while the second set was reinforced with continuous fibers. The plates were tested with quasi-static indentation tests at various Span-to-Punch ratios and with three different indenter nose shapes (blunt, hemispherical, and conical). The quasi-static measurements were subsequently elaborated to estimate the energy absorption capability of the plates during a ballistic impact. The addition of continuous fibers increased the quasi-static energy absorption capability by 20–185% with respect to the short-fiber-reinforced plates. The quasi-static results showed that by including the continuous reinforcement in the plates, the normalized energy absorbed increased by an order of magnitude. Finally, a comparison with data from the literature concerning continuous-reinforced composite plates manufactured by means of traditional techniques was carried out. The comparison revealed that FFF-printed composite plates can compete with traditional composite ones in terms of both ballistic and quasi-static penetrating load conditions, even if limited by the lower fiber volume fraction. Thus, these findings confirm that this novel Additive Manufacturing technique is promising and worth investigating further.
Investigation on the Preparation and Performances of Epoxy-Modified Asphalt Binder and Its Mixtures
Authors: Liu Xiaodong , Wu Zhiheng , Min Zhaohui , Zhang Lei
Published: May 2024

Epoxy-modified asphalt binder has been widely used in steel deck pavement due to its excellent properties and it is a potential candidate for long life pavements. However, its short reserve time limits its widespread application in pavement engineering. Therefore, this work developed a novel epoxy-modified asphalt binder composed of a laboratory-made curing agent as a solution. Firstly, optimization of preparation temperature of this new material was studied to balance the requirements of enough construction time and the material strength and elongation. The epoxy-modified asphalt binder, prepared at the optimal temperature of 140 °C, had a reserve time exceeding 120 min, whereas the tensile strength and the elongation at failure were 2.22 MPa and 216%, respectively, which satisfied the standard requirements of paving epoxy material well. Secondly, the asphalt mixture property tests demonstrate excellent high-temperature rutting resistance, water stability and low-temperature anti-cracking ability. Additionally, the compatibility and colloidal stability of this epoxy-modified asphalt binder were analyzed in terms of microphase structure. The uniform microphase distribution of this binder showed by the laser confocal microscope observation in both short-term aging case and long-term aging case, indicates the great compatibility between asphalt and epoxy resin during paving process and service life. Furthermore, fatigue tests were conducted to evaluate the long-term durability. The fatigue life of epoxy-modified asphalt mixtures increased by 435%, 427%, 342%, and 276% under the stress ratios of 0.3, 0.4, 0.5, and 0.6, respectively, compared to those of SBS-modified asphalt mixtures. All these results indicate that the new epoxy-modified asphalt material is promising for applications in pavement engineering, especially suitable for long-life road pavement.
Influence of Cold Wave Diversities on Thermal Stress and Thermal Fatigue Life of Asphalt Mixture
Authors: Haimei  , Li Lili , Guo Qinglin , He Wenli , Xu Aosen
Published: May 2024

Apart from low-temperature cracking, asphalt pavement may also suffer from thermal fatigue cracking. To clarify the impact of cold waves on the thermal fatigue performance of asphalt mixtures, the typical atmospheric temperature characteristics of different regions in China from 2012 to 2019 were analyzed, and the frequency of cold waves in these regions was determined. The viscoelastic parameters of an asphalt mixture are determined through an indirect tensile relaxation test. The thermal stress of the asphalt mixture is simulated and analyzed by using the finite element method. The effect of cold waves on the thermal fatigue life of the asphalt mixture was evaluated. The results show that the frequency of cold waves is different from region to region in China, and the cold waves mainly occurred from October of one year to February of the next year. Northeast China has the most frequency and the largest temperature drop amplitude, followed by North China. The maximum thermal stress increases with the decrease in temperature drop and initial temperature and is unrelated to the duration of cold waves. The thermal stress calculated based on the atmospheric thermal boundary is higher than the value using the road surface temperature. The thermal fatigue lives of asphalt mixtures in North China and Northeast China are very short, while the thermal fatigue life of the mixture in Central China is the longest. To meet the requirement of thermal fatigue damage caused by cold waves during the designed service stage, the recommended threshold for thermal stress is 0.39–0.77 MPa.
Application of a Multi-Criterion Decision-Making Method for Solving the Multi-Objective Optimization of a Two-Stage Helical Gearbox
Authors: Dinh Van-Thanh , Tran Huu-Danh , Vu Duc-Binh , Vu Duong , Vu Ngoc-Pi , Luu Anh-Tung
Published: May 2024

This paper provides a novel application of a multi-criterion decision-making (MCDM) method to the multi-objective optimization problem of designing a two-stage helical gearbox. This study’s goal is to identify the ideal primary design elements that increase gearbox efficiency while reducing the gearbox cross-section area. In this work, three primary design parameters were selected for investigation: the gear ratio of the first stage and the coefficients of wheel face width (CWFW) of the first and second stages. The multi-objective optimization problem was further split into two phases: phase 1 solved the single-objective optimization problem of minimizing the gap between the variable levels, and phase 2 solved the multi-objective optimization issue of identifying the ideal key design factors. Moreover, the multi-objective optimization problem was handled by the SAW method as an MCDM approach, and the weight criteria were computed using the entropy approach. This study’s significant characteristics are as follows: First, a multi-objective optimization problem was successfully solved using the MCDM approach (SAW technique) for the first time. Second, the power losses in idle motion were investigated in this work in order to determine the efficiency of a two-stage helical gearbox. From this study’s findings, the ideal values for three major design parameters can be determined for the design of a two-stage helical gearbox.
Dynamics of Hepatitis B Virus Transmission with a Lévy Process and Vaccination Effects
Authors: Shah Sayed Murad Ali , Nie Yufeng , Din Anwarud , Alkhazzan Abdulwasea
Published: May 2024

This work proposes a novel stochastic model describing the propagation dynamics of the hepatitis B virus. The model takes into account numerous disease characteristics, and environmental disturbances were collected using Lévy jumps and the conventional Brownian motions. Initially, the deterministic model is developed, and the asymptotic behavior of the model’s solution near the equilibria is examined. The deterministic model is transformed into a stochastic model while retaining the Lévy jumps and conventional Brownian motions. Under specific assumptions, the stochastic system is shown to have a unique solution. The study further investigates the conditions that ensure the extinction and persistence of the infection. The numerical solutions to both stochastic and deterministic systems were obtained using the well-known Milstein and RK4 techniques, and the analytical findings are theoretically confirmed. The simulation suggests that the noise intensities have a direct relationship with the amplitudes of the stochastic curves around the equilibria of the deterministic system. Smaller values of the intensities imply negligible fluctuations of trajectories around the equilibria and, hence, better describe the extinction and persistence of the infection. It has also been found that both Brownian motions and the Lévy jump had a significant influence on the oscillations of these curves. A discussion of the findings of the study reveals other important aspects as well as some future research guidelines. In short, this study proposes a novel stochastic model to describe the propagation dynamics of the hepatitis B virus.
Lp-Boundedness of a Class of Bi-Parameter Pseudo-Differential Operators
Authors: Cheng Jinhua
Published: May 2024

In this paper, I explore a specific class of bi-parameter pseudo-differential operators characterized by symbols σ(x1,x2,ξ1,ξ2) falling within the product-type Hörmander class Sρ,δm. This classification imposes constraints on the behavior of partial derivatives of σ with respect to both spatial and frequency variables. Specifically, I demonstrate that for each multi-index α,β, the inequality |∂ξα∂xβσ(x1,x2,ξ1,ξ2)|≤Cα,β(1+|ξ|)m∏i=12(1+|ξi|)−ρ|αi|+δ|βi| is satisfied. My investigation culminates in a rigorous analysis of the Lp-boundedness of such pseudo-differential operators, thereby extending the seminal findings of C. Fefferman from 1973 concerning pseudo-differential operators within the Hörmander class.
Antiretroviral Therapy Switch in HIV-Infected Adults from a Regional HIV/AIDS Center in NE Romania
Authors: Loghin Isabela Ioana , Rusu Șerban Alin , Vâţă Andrei , Cobaschi Mihaela , Cecan Ion , Manciuc Carmen , Dorobăţ Carmen Mihaela
Published: May 2024

Background and Objectives: Antiretroviral therapy (ART) has revolutionized the management of HIV infection, transforming it from a once-debilitating disease to a chronic, manageable condition. However, challenges such as treatment resistance, medication side effects, and long-term tolerability persist, prompting the exploration of novel therapeutic approaches. We aimed to highlight the characteristics and related comorbidities of HIV/AIDS cases in which the antiretroviral therapy was modified. Material and Methods: A cross-sectional clinical investigation was conducted on adults diagnosed with HIV/AIDS who were hospitalized at the “St. Parascheva” Clinical Hospital of Infectious Diseases in Iasi in the Northeastern region of Romania. The timeframe under investigation was 1 January 2023 to 30 June 2023. Results: In the Northeastern part of Romania, from a total of 1692 patients in the active records, there were a total of 148 recorded cases of antiretroviral therapy switch in HIV-infected patients. The main reason for the ART switch was the simplification of the ART regimen (82 cases, 55.40%), viro-immunological failure (16 cases, 10.66%), other disturbances correlated to the ART regimen, dyslipidemia (34 cases 22.97%), depression (3 cases, 2.02%), suicide attempt (1 case, 0.67%), new situations, including the appearance of pregnancy (3 cases 2.02%), and tuberculosis (9 cases, 6.08%). ART before the switch was represented by protease inhibitors that accounted for 84 cases (56.75%) of the ART switch. Following the therapy switch, integrase inhibitor-based ART single-tablet regimens accounted for 43.91% (65 cases) of all changeovers, with non-nucleoside reverse transcriptase inhibitor regimens coming in second, in 63 cases, 42.66%. Conclusions: ART switch as an experimental therapy offers a promising approach to optimizing HIV treatment outcomes. By focusing on viral suppression and immune reconstitution, addressing treatment challenges, and exploring novel ARV agents, ART switch strategies aim to improve the overall health and well-being of individuals living with HIV.
Deciphering Microbial Shifts in the Gut and Lung Microbiomes of COVID-19 Patients
Authors: Pusadkar Vaidehi , Mazumder Anirudh , Azad Abhijay , Patil Deepti , Azad Rajeev K.
Published: May 2024

COVID-19, caused by SARS-CoV-2, results in respiratory and cardiopulmonary infections. There is an urgent need to understand not just the pathogenic mechanisms of this disease but also its impact on the physiology of different organs and microbiomes. Multiple studies have reported the effects of COVID-19 on the gastrointestinal microbiota, such as promoting dysbiosis (imbalances in the microbiome) following the disease’s progression. Deconstructing the dynamic changes in microbiome composition that are specifically correlated with COVID-19 patients remains a challenge. Motivated by this problem, we implemented a biomarker discovery pipeline to identify candidate microbes specific to COVID-19. This involved a meta-analysis of large-scale COVID-19 metagenomic data to decipher the impact of COVID-19 on the human gut and respiratory microbiomes. Metagenomic studies of the gut and respiratory microbiomes of COVID-19 patients and of microbiomes from other respiratory diseases with symptoms similar to or overlapping with COVID-19 revealed 1169 and 131 differentially abundant microbes in the human gut and respiratory microbiomes, respectively, that uniquely associate with COVID-19. Furthermore, by utilizing machine learning models (LASSO and XGBoost), we demonstrated the power of microbial features in separating COVID-19 samples from metagenomic samples representing other respiratory diseases and controls (healthy individuals), achieving an overall accuracy of over 80%. Overall, our study provides insights into the microbiome shifts occurring in COVID-19 patients, shining a new light on the compositional changes.
Performance of Halo-Alkali-Tolerant Endophytic Bacteria on Hybrid Pennisetum and Bacterial Community under Varying Soil Conditions
Authors: Li Xia , Ding Yiming , Okoye Charles Obinwanne , Geng Xiaoyan , Jiang Huifang , Wang Yongli , Wu Yanfang , Gao Lu , Fu Lei , Jiang Jianxiong , Sun Jianzhong
Published: May 2024

Halo-alkali soil threatens agriculture, reducing growth and crop yield worldwide. In this study, physicochemical and molecular techniques were employed to explore the potential of halo-alkali-tolerant endophytic bacteria strains Sphingomonas sp. pp01, Bacillus sp. pp02, Pantoea sp. pp04, and Enterobacter sp. pp06 to enhance the growth of hybrid Pennisetum under varying saline conditions. The strains exhibited tolerance to high salt concentrations, alkaline pH, and high temperatures. Under controlled conditions, all four strains showed significant growth-promoting effects on hybrid Pennisetum inoculated individually or in combination. However, the effects were significantly reduced in coastal saline soil. The best growth-promoting effect was achieved under greenhouse conditions, increasing shoot fresh and dry weights of hybrid Pennisetum by up to 457.7% and 374.7%, respectively, using irrigating trials. Metagenomic sequencing analysis revealed that the diversity and composition of rhizosphere microbiota underwent significant changes after inoculation with endophytic bacteria. Specifically, pp02 and co-inoculation significantly increased the Dyella and Pseudomonas population. Firmicutes, Mycobacteria, and Proteobacteria phyla were enriched in Bacillus PP02 samples. These may explain the best growth-promoting effects of pp02 and co-inoculation on hybrid Pennisetum under greenhouse conditions. Our findings reveal the performance of endophytic bacterial inoculants in enhancing beneficial microbiota, salt stress tolerance, and hybrid Pennisetum growth.
Molecular Characterization of the Chicken Parvovirus Based on VP1 Gene Circulating in Brazilian Chicken Flocks
Authors: Nuñez Luis F. N. , Santander-Parra Silvana H. , Astolfi-Ferreira Claudete S. , Loor-Giler Anthony , Ferreira Antonio J. P.
Published: May 2024

Parvovirus infection affects several animal species, especially young animals. In birds, parvovirus infection has been described in Muscovy ducks, turkeys, and chickens, all of which had enteric diseases characterized by diarrhea. Chicken parvovirus (ChPV) has been detected in poultry around the world in animals affected by enteric problems, showing dwarfism, cloacal pasting, and diarrhea. In Brazil, ChPV was detected in chickens affected by diarrhea fifteen years ago. However, the genetic characteristics of ChPV circulating in chicken flocks were not determined. Therefore, the aim of the present investigation was to determine the genetic characteristics of the VP1 gene from ChPV detected in chickens affected by enteric diseases in Brazil. For this purpose, a molecular approach was used. Specific primers were designed to flank the complete VP1 gene of ChPV and amplify it using PCR. The amplified products from samples of chickens with enteric diseases were sequenced, and 22 complete CDs of the VP1 gene were obtained. These samples, compared to the ABU-P1 sequence, showed 17 sequences with high nucleotide (NT) similarity of 92.7–97.4% and amino acid (AA) similarity of 94.8–99.5% associated with Runting and Stunting syndrome (RSS); there were also five samples associated with hens with diarrhea with unusual jejunal dilatation (JD) that had less similarity than the RSS sequences (NT of 86.5% and AA of 93–93.1%). The phylogenetic analysis determined four groups. Group I had sequences from Korea. The second group included sequences from Korea, China, and Brazil (not included in this work). The third group had studied RSS sequences grouped with the ABU-P1 strain and sequences from China and the United States. Finally, the sequences from JD were clustered in a separate group with a bootstrap of 100%, a group that was denoted as group IV, and included sequences from China. RDP4 and SimPlot analysis showed one point of recombination with the sequences of group III ChPV in the JD sequences. Herein, we show that circulating strains of ChPV exhibit genetic differences in the VP1 gene in Brazilian chicken flocks. Nevertheless, more studies are needed to determine the probability of a new genetic group of ChPV based on the analysis of the complete genome.
A Review of Relationship between the Metallogenic System of Metallic Mineral Deposits and Lithospheric Electrical Structure: Insight from Magnetotelluric Imaging
Authors: Jin Sheng , Sheng Yue , Liu Chenggong , Wei Wenbo , Ye Gaofeng , Jing Jianen , Zhang Letian , Dong Hao , Yin Yaotian , Xie Chengliang
Published: May 2024

In development over 70 years, magnetotelluric (MT) sounding, a high-resolution technique for subsurface electrical resistivity imaging, has been widely applied in resource exploration in the Earth. The key factors of the metallogenic system of metallic mineral deposits can be closely correlated to the electrical anomalies of the lithosphere. In this paper, we review the relationship between the electrical resistivity model of the lithosphere and the metallogenic system. At the beginning, we indicate why the electrical parameters relate to the metallogenic system in all geophysical parameters. The advantage of MT sounding in sketching an electrical resistivity model of the lithosphere is subsequently discussed, and some methods of data processing, analysis and inversion are also introduced. Furthermore, we summarize how to bridge the relationship between the electrical resistivity model of the lithosphere and metallogenic system, and analyze the influence of the rheological variation estimated from conductivity in the lithosphere on mineralization. In the end, we list some typical cases of the application of MT sounding in mineral exploration, and also give some suggestions for future work. This study is aimed at providing guidance in discussing the metallogenic system using an electrical resistivity model.
Geochronology and Geochemistry of Granitic Pegmatites from Tashidaban Li Deposit in the Central Altun Tagh, Northwest China
Authors: Kang Kai , Ma Yince , Zhang Peng , Li Hang , Wang Xuehai , Liao Zhaoxia , Niu Lei , Chen Jianzhong , Liu Xingzhong , Xu Xingwang
Published: May 2024

The Central Altun orogenic system is a result of the amalgamation of multiple micro-continental blocks and island arcs. This complex system originated from subduction–accretion–collision processes in the Proto-Tethys Ocean during the Early Paleozoic. Research has reported the discovery of several Li-Be granitic pegmatite deposits in the Central Altun Block, including the North Tugeman granitic pegmatite Li-Be deposit, Tugeman granitic pegmatite Be deposit, Tashisayi granitic pegmatite Li deposit, South Washixia granitic pegmatite Li deposit, and Tamuqie granitic pegmatite Li deposit. The Tashidaban granitic pegmatite Li deposit has been newly discovered along the northern margin of the Central Altun Block. Field and geochemical studies of the Tashidaban granitic pegmatite Li deposit indicate: (1) Spodumene pegmatites and elbaite pegmatites, as Li-bearing granitic pegmatites that form the Tashidaban granitic pegmatite Li deposit, intrude into the two-mica schist, and marble of the Muzisayi Formation of the Tashidaban Group. (2) Columbite–tantalite group minerals and zircon U-Pb dating results indicate that the mineralization age of Tashidaban Li granitic pegmatites is 450.2 ± 2.4 Ma with a superimposed magmatic event at around 418–422 Ma later. (3) Whole-rock geochemical results indicate that the Kumudaban rock sequence belongs to the S-type high-K to calc-alkaline granites and the Tashidaban Li granitic pegmatites originated from the extreme differentiation by fractional crystallization of the Kumdaban granite pluton.
Porosity Characteristics of Coal Seams and the Control Mechanisms of Coal Petrology in the Xishanyao Formation in the Western Part of the Southern Junggar Basin
Authors: Yuan Yuan , Tang Yue , Tong Lihua , Cao Daiyong , Wei Yingchun , Bi Caiqin
Published: May 2024

The porosity characteristics of coal seams serve as a pivotal factor in assessing the development potential of coalbed methane (CBM) resources, significantly influencing the adsorption and permeability capabilities of coal reservoirs, as well as the accumulation, entrapment, and preservation of CBM. In this study, we focused on the coal seams of the Xishanyao Formation in the western part of the southern Junggar Basin (NW China). By leveraging the complementarity of nuclear magnetic resonance (NMR), low-temperature liquid nitrogen experiments, and high-pressure mercury intrusion porosimetry (MIP) in spatial exploration range and precision, we conducted a comprehensive analysis to achieve a fine description of porosity characteristics. Furthermore, we explored the coal petrology factors controlling the pore characteristics of the Xishanyao Formation, aiming to provide geological evidence for the selection of favorable areas and the development potential evaluation of CBM in the study area. The results indicate the following: (1) The total pore volume of the coal samples is 6.318 × 10−3 cm3/g on average, and the micropore volume accounts for a relatively high proportion (averaging 44.17%), followed by the fine pores (averaging 39.41%). The average porosity is approximately 3.87%, indicating good gas storage and connectivity of the coal seams, albeit with some heterogeneity. The coal reservoir is dominated by micropores and fine pores with diameters less than 100 nm, and the pore structure is characterized by low pore volume and high pore area. (2) The pore structure is influenced by both the coalification degree and the coal maceral. Within the range of low coalification, porosity increases with the increase in coalification degree. Building upon this, an increase in the vitrinite content promotes the development of micropores and fine pores, while an increase in the inertinite content promotes the development of meso–macropores. The clay mineral content exhibits a negative correlation with the adsorption pore volume ratio and a positive correlation with the seepage pore volume ratio.
Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles
Authors: Paw Beata , Śliwa Rafał , Komsta Łukasz , Senczyna Bogusław , Karpińska Monika , Matysiak Joanna
Published: May 2024

The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the drug candidates design and development. The lipophilicity of compounds was determined using the computational (log P) and chromatography (log kw, RMw) methods. The experimental ones included the reverse-phase column high performance liquid chromatography RP (HPLC) with C8, C18, phosphatidylcholine (IAM), and cholesterol stationary phases and the thin layer chromatography (RP-HPTLC) with C8 and C18 stationary phases and various organic modifiers under the isocratic conditions. Descriptive statistics, correlation, and PCA analyses were used to compare the obtained results. For lipophilicity estimation of the tested compounds by HPTLC, dioxane and MeOH seem to be particularly beneficial as organic modifiers. The chromatographic lipophilicity parameters log kw (RMw) were well correlated and highly redundant (85%) compared with those calculated. Most compounds possess lipophilicity parameters within the recommended range for drug candidates.
Are Terminal Alkynes Necessary for MAO-A/MAO-B Inhibition? A New Scaffold Is Revealed
Authors: Mavroeidi Panagiou , Zorba Leandros P. , Tzouras Nikolaos V. , Neofotistos Stavros P. , Georgiou Nikitas , Sahin Kader , Şentürk Murat , Durdagi Serdar , Vougioukalakis Georgios C. , Mavromoustakos Thomas
Published: May 2024

A versatile family of quaternary propargylamines was synthesized employing the KA2 multicomponent reaction, through the single-step coupling of a number of amines, ketones, and terminal alkynes. Sustainable synthetic procedures using transition metal catalysts were employed in all cases. The inhibitory activity of these molecules was evaluated against human monoaminoxidase (hMAO)-A and hMAO-B enzymes and was found to be significant. The IC50 values for hMAO-B range from 152.1 to 164.7 nM while the IC50 values for hMAO-A range from 765.6 to 861.6 nM. Furthermore, these compounds comply with Lipinski’s rule of five and exhibit no predicted toxicity. To understand their binding properties with the two target enzymes, key interactions were studied using molecular docking, all-atom molecular dynamics (MD) simulations, and MM/GBSA binding free energy calculations. Overall, herein, the reported family of propargylamines exhibits promise as potential treatments for neurodegenerative disorders, such as Parkinson’s disease. Interestingly, this is the first time a propargylamine scaffold bearing an internal alkyne has been reported to show activity against monoaminoxidases.