bluuebunny/crossref_metadata_2025 huggingface dataset:
Alleviation of Drought Stress in Soybean [Glycine max (L.) Merril] by Foliar Application of Thiourea on Productivity and Profitability under Rainfed Condition
Authors: Somanagouda G. , Channakeshava R. , Huilgol Shalini N. , Naidu G.K. , Banu Harshiya
Published: July 2024

Background: In changing climatic scenario, plants often face periods of soil and atmospheric water deficits because of scarcity of water availability and deteriorating quality across the globe. Drought stress is the one of the major abiotic factors that reduce plant water status, obstructs photosynthesis, brings oxidative stress hindering soybean productivity. In view of this, bioregulators (thiourea) are innovative agricultural technique used to protect plants, minimizing the adverse effects caused by environmental stress. Therefore, an alternative to improve crop yield under rainfed condition by application of bioregulators like thiourea and suitable varieties are important in order to mitigate stress in soybean production. Methods: The field experiments were conducted in Factorial RBD with three replications. To know the impact of foliar spray of thiourea on growth, physiological parameters, yield parameters, yield and economics of two soybean varieties were carried out during kharif 2020, 2021 and 2022. Result: Long term results showed that, by using MACS 1188 variety of soybean and foliar spray of thiourea at 500 ppm and 750 ppm during the 25 and 55 DAS is a commendatory option and most remunerative for farmers to improve the productivity and profitability of soybean in Northern Transition Zone of Karnataka.
Effects of Prolonged High Salinity Stress on Alfalfa (Medicago sativa L.) Cultivars and Populations
Authors: Efe Berna , Ergün Namuk , Sancak Cengiz
Published: July 2024

Background: Alfalfa is a promising crop for improving soil structure and restoring agricultural land, particularly in areas affected by salinity. However, high and continuing salinity in soil and irrigation water can pose a significant challenge to the growth and productivity of alfalfa. The objective of this study was to investigate the effects of prolonged high salinity stress on alfalfa cultivars and populations. Methods: The material used in this study included 16 alfalfa populations and four alfalfa cultivars that exhibit salt tolerance during germination and early seedling development. The materials were exposed to 17.52 dS m-1 saline irrigation water stress for three months. As well as the morphology, survival at three months and crude ash, sodium and chloride ions were measured. Result: Salt-tolerant plants showed a slowdown in growth compared to control conditions, although they were still able to maintain growth. Duration and severity of stress affected the salt tolerance of the genotypes. The survival rates of the materials remained relatively unchanged for the first two months, but decreased significantly by the end of the third month. Furthermore, the survival rate of the materials increased as the amount of sodium and chloride ions absorbed by the plant decreased under high salinity conditions. Genetic material demonstrating long-term high salinity tolerance is crucial for resistance breeding and holds promise for the development of tolerant cultivars that can be grown under field conditions in the future. The properties of this material need to be determined and its long-term performance in field conditions needs to be tested.
Filizlenen Çift Dillilik Gelişimi ve Çift Dilli Okuryazarlık Eğitiminde Teknoloji Entegrasyonu
Authors: Ünal Gezer Melike
Published: July 2024

Çift dillilik, dünya geneli ve Türkiye özelinde küreselleşmeyle her zamankinden daha önemli hale gelmiş bir olgudur. Globalleşmenin getirdiği gereksinimler ülke eğitim sistemlerinin değişimine neden olmuş, dünya dili olan İngilizce’nin yabancı dil olarak öğretimi erken yaşlara çekilmiştir. Yabancı dile erken yaşta maruz kalan çocuklar filizlenen yabancı dil okuryazarlığı geliştiriyor ve bu süreçte hedef dilin imla kuralları, telaffuzu, kelimeleri oluşturan sesleri tanıma, manipüle etme, kelimelerdeki anlamlı birimleri irdeleme gibi yetkinliklerle erken yaşlardan itibaren donanıyorlar. Teknolojinin hem dersliklerde hem de evlerde yaygınlıkla kullanıldığı günümüz dünyasında ana dil ve hedef dilde ilerleme, okuryazarlık geliştirme, elektronik kitap, dijital kütüphane gibi eğitsel teknolojiler, yazma, kelime öğrenimi gibi dil becerilerini hedefe alan aplikasyon-uygulamalarla etkili biçimde sürdürülmektedir. Söz konusu çalışma, erken yaştan itibaren iki dillilik ve çift dilli erken okuryazarlık gelişimini vurgulamayı hedeflemiş, günümüz teknolojilerinin iki dilde filizlenen okuryazarlık gelişimini ne seviyede destekleyebileceğini incelemiş, alanyazından çalışmaların bilgisini sunarak konunun önemine vurgu yapmıştır. İrdelenen teknoloji ve destekleyici alanyazın doğrultusunda, eğitimci, veli ve çocuklara farklı okuryazarlık hedeflerine uygun platformların bilgisi sunulmuş, teknolojinin iki dillilik gelişimine katkıları açıklanarak bu alana dikkat çekilmiştir.
Relationships between endurance exercise training-induced muscle
fiber-type shifting and autophagy in slow- and fast-twitch skeletal muscles of mice
Authors: Kwon Insu , Kim Kyoung Soo , Lee Youngil
Published: July 2024

[Purpose] Endurance exercise induces muscle fiber-type shifting and autophagy; however, the potential role of autophagy in muscle fiber-type transformation remains unclear. This study examined the relationship between muscle fiber-type shifting and autophagy in the soleus (SOL) and extensor digitorum longus (EDL) muscles, which are metabolically discrete muscles.[Methods] Male C57BL/6J mice were randomly assigned to sedentary control (CON) and exercise (EXE) groups. After 1 week of acclimation to treadmill running, the mice in the EXE group ran at 12-15 m/min, 60 min/day, 5 days/week for 6 weeks. All mice were sacrificed 90 min after the last exercise session, and the targeted tissues were rapidly dissected. The right side of the tissues was used for western blot analysis, whereas the left side was subjected to immunohistochemical analysis.[Results] Endurance exercise resulted in muscle fiber-type shifting (from type IIa to type I) and autophagy (an increase in LC3-II) in the SOL muscle. However, muscle fiber-type transformation and autophagy were not correlated in the SOL and EDL muscles. Interestingly, in contrast to the canonical autophagy signaling pathways, our study showed that exercise-induced autophagy concurs with enhanced anabolic (increased p-AKTSer473/AKT and p-mTOR/mTORSer2448 ratios) and suppressed catabolic (reduced p-AMPKThr172/AMPK ratio) states.[Conclusion] Our findings demonstrate that chronic endurance exercise-induced muscle fiber-type transformation and autophagy occur in a muscle-specific manner (e.g., SOL). More importantly, our study suggests that endurance training-induced SOL muscle fiber-type transition may underlie metabolic modulations caused by the AMPK and AKT/mTOR signaling pathways rather than autophagy.
Readjustment of circadian clocks by exercise intervention is a potential therapeutic target for sleep disorders: a narrative review
Authors: Lee Kwangjun , Hong Kwang-Seok , Park Jonghoon , Park Wonil
Published: July 2024

[Purpose] Circadian clocks are evolved endogenous biological systems that communicate with environmental cues to optimize physiological processes, such as the sleep-wake cycle, which is nearly related to quality of life. Sleep disorders can be treated using pharmacological strategies targeting melatonin, orexin, or core clock genes. Exercise has been widely explored as a behavioral treatment because it challenges homeostasis in the human body and affects the regulation of core clock genes. Exercise intervention at the appropriate time of the day can induce a phase shift in internal clocks. Although exercise is a strong external time cue for resetting the circadian clock, exercise therapy for sleep disorders remains poorly understood.[Methods] This review focused on exercise as a potential treatment for sleep disorders by tuning the internal circadian clock. We used scientific paper depositories, including Google Scholar, PubMed, and the Cochrane Library, to identify previous studies that investigated the effects of exercise on circadian clocks and sleep disorders.[Results] The exercise-induced adjustment of the circadian clock phase depended on exercise timing and individual chronotypes. Adjustment of circadian clocks through scheduled morning exercises can be appropriately prescribed for individuals with delayed sleep phase disorders. Individuals with advanced sleep phase disorders can synchronize their internal clocks with their living environment by performing evening exercises. Exercise-induced physiological responses are affected by age, sex, and current fitness conditions.[Conclusion] Personalized approaches are necessary when implementing exercise interventions for sleep disorders.
How to better estimate bunch number at field level?
Authors: Oger Baptiste , Laurent Cécile , Vismara Philippe , Tisseyre Bruno
Published: July 2024

In viticulture, early-season estimation of average number of grape bunches per vine is crucial for vineyard planning, investments and marketing (Laurent et al., 2021). Although sampling is widely carried out to estimate grape bunches per vine, there is no clearly established sampling protocol that can be used as a reference when performing these estimations. Each practitioner therefore has their own sampling protocol. In this work, the effect of differences between sampling protocols in terms of estimation errors were investigated to give some recommendations on the best possible sampling practices.
On Some Specific Order Estimates for the Mertens Function and Its Relation to the Non-trivial Zeros of $\zeta(s)$
Authors: De Subham
Published: July 2024

The primary purpose of this article is to provide a brief overview about the notion of the \textit{Mertens Function} $M(n)$ and \textit{Redheffer Matrices} $\mathbb{A}_{n}$ and, to derive specific order estimates for $M(n)$, in order to analyze the location of the non-trivial zeros of the \textit{Riemann Zeta function} $\zeta(s)$. A priori using the above concepts, the article aims at establishing a necessary and sufficient condition for the \textit{Riemann Hypothesis} to hold true.
Alena Tensor and Its Possible Applications in Unification Theories
Authors: Ogonowski Piotr , Skindzier Piotr
Published: July 2024

Alena Tensor is a recently discovered class of energy-momentum tensors that provides mathematical framework in which, as demonstrated in previous publications, the description of a physical system in curved spacetime and its description in flat spacetime with fields are equivalent. The description of a system with electromagnetic field based on Alena Tensor can be used to reconcile physical descriptions. 1) In curvilinear description, Einstein Field Equations were obtained with Cosmological Constant related to the invariant of the electromagnetic field tensor, which can be interpreted as negative pressure of vacuum, filled with electromagnetic field. 2) In classical description for flat spacetime, three densities of four-forces were obtained: electromagnetic, gravity, and the force responsible for the Abraham-Lorentz effect (radiation reaction force). Obtained connection of Einstein tensor with gravity and radiation reaction force, after transition to curvilinear description, excludes black hole singularities. There was obtained Lagrangian density and generalized canonical four-momentum, containing electromagnetic four-potential and a term responsible for other two forces. In this description charged particles cannot remain at complete rest and should have spin, their energy results from the existence of the energy of the magnetic moment and the density of this energy is part of the Poyting four-vector. The distribution of charged matter was expressed as polarization-magnetization stress-energy tensor, what may explain why gravity is invisible in QED. 3) In quantum picture, QED Lagrangian density simplification was obtained, and the Dirac, Schrödinger and Klein-Gordon equations may be considered as approximations of the obtained quantum solution. Farther use of Alena Tensor in unification applications was also discussed.
Highly-Sensitive Measure of Complexity Captures Boolean Networks Regimes and Temporal Order More Optimally
Authors: Luevano Manuel de J. , Puga Alejandro
Published: July 2024

In this work, several random Boolean networks (RBN) are generated and analyzed from two characteristics: their time evolution diagram and their transition diagram. To do this, its randomness is estimated using three measures, of which Algorithmic Complexity is the only one capable of both a) revealing transitions towards the chaotic regime, and b) disclosing the algorithmic contribution of certain states to the transition diagram and their relationship with the order they occupy in the temporal evolution of the respective RBN. The results obtained from both types of analysis are useful for the introduction of both Algorithmic Complexity and Perturbation Analysis in the context of Boolean networks, and their potential applications in regulatory network models.
Deep Venous Thrombosis as an Initial Manifestation of Rectal Adenocarcinoma Metastasis to Skeletal Muscle: Case Report
Authors: Tsai Tsung-Jung , Chang Yu-Yao
Published: July 2024

As times goes, the survival was improved attributed to target therapy and chemotherapy. Metastasis to skeletal muscle tissue is rare. Herein, we reported a case presenting with deep venous thrombosis but skeletal muscle metastasis. Though it was rare, oncologist shoud be keep in mind due to worse prognosis.
Deep Venous Thrombosis as an Initial Manifestation of Rectal Adenocarcinoma Metastasis to Skeletal Muscle: Case Report
Authors: Tsai Tsung-Jung , Chang Yu-Yao
Published: July 2024

Colorectal cancer is third most common malignancy. For metastasis of rectal cancer, metastasis to skeletal muscle tissue is rare. In this case report, we describe a 51-year-old male patient with rectal cancer with neoadjuvant concurrent radiotherapy and chemotherapy followed by transanal total mesorectal excision with ileostomy. However, he had deep venous thrombosis of left leg after operation and skeletal muscle metastasis was diagnosed via tissue proof. Therefore, less possibility of metastasis increased included brain, duodenum, bone, and nervous system. The prognosis of metastasis to skeletal muscle is poor in contrast to liver or lung metastasis.
An Inquiry into the Application of Biophilic Design Principles in Contemporary University Designs
Authors: Yasar Dilek , Öktem Erkartal Pınar
Published: July 2024

Human beings are positively or negatively affected by their environment. This effect has been a topic of interest for environmental psychologists, who have strived over years to understand the environmental attributes, which would be favourable to people in physical, mental, and psychological terms. The present study focusses on biophilic design, one of the popular theories in the architectural literature aimed to create high quality and liveable environments. The positive effects of biophilic design have been investigated from different perspectives and thus it has become a well-accepted approach in the relevant architectural literature. Accordingly, the present study aimed to investigate to what extent biophilic design principles were put into practice. In the context thereof, contemporary university structures were analysed within the framework of biophilic design principles. The results were suggestive of the fact that although biophilic elements were encountered in the design of these structures, they were not meant to be biophilic, nevertheless, there was an approach based on human-nature interaction. Accordingly, the principles of biophilic design were equivalent to the required parameters of a good design and that architects considered nature as an important design input.
On proving an Inequality of Ramanujan using Explicit Order Estimates for the Mertens Function
Authors: De Subham
Published: July 2024

This research article provides an unconditional proof of an inequality proposed by \textit{Srinivasa Ramanujan} involving the Prime Counting Function $\pi(x)$, \begin{align*} (\pi(x))^{2}<\frac{ex}{\log x}\pi\left(\frac{x}{e}\right) \end{align*} for every real $x\geq \exp(547)$, using specific order estimates of the \textit{Mertens Function}, $M(x)$. The proof primarily hinges upon investigating the underlying relation between $M(x)$ and the \textit{Second Chebyshev Function}, $\psi(x)$, in addition to applying the meromorphic properties of the \textit{Riemann Zeta Function}, $\zeta(s)$ with an intention of deriving an improved approximation for $\pi(x)$.
Inequalities involving Higher Degree Polynomial Functions in $\pi(x)$
Authors: De Subham
Published: July 2024

The primary purpose of this article is to study the asymptotic and numerical estimates in detail for higher degree polynomials in $\pi(x)$ having a general expression of the form, \begin{align*} P(\pi(x)) - \frac{e x}{\log x} Q(\pi(x/e)) + R(x) \end{align*} $P$, $Q$ and $R$ are arbitrarily chosen polynomials and $\pi(x)$ denotes the \textit{Prime Counting Function}. The proofs require specific order estimates involving $\pi(x)$ and the \textit{Second Chebyshev Function} $\psi(x)$, as well as the famous \textit{Prime Number Theorem} in addition to certain meromorphic properties of the \textit{Riemann Zeta Function} $\zeta(s)$ and results regarding its non-trivial zeros. A few generalizations of these concepts have also been discussed in detail towards the later stages of the paper, along with citing some important applications.
Triaxiality and Plastic Strain Dependent Proposed PEAK Parameter for Predicting Crack Formation in Polypropylene Polymer Reservoir Subjected to Pressure Load
Authors: Kasprzak Adam
Published: July 2024

This article raise a topic of critical examination of polypropylene, a key polymeric material, and its extensive application within the automotive industry, particularly focusing on the manufacturing of brake fluid reservoirs. The study aims to enhance the understanding of polypropylene's behavior under mechanical stresses through a series of laboratory destruction tests and numerical simulations, emphasizing the Finite Element Method (FEM). A novel aspect of this research is the introduction of the PEAK parameter, a groundbreaking approach designed to assess the material's resilience against varying states of strain, known as triaxiality. This parameter facilitates the identification of critical areas prone to crack initiation, thereby enabling the optimization of component design with a minimized safety margin, which is crucial for cost-effective production. The methodology involves conducting burst tests to locate crack initiation sites, followed by FEM simulations to determine the PEAK threshold value for the Sabic 83MF10 polypropylene material. The study successfully validates the predictive capability of the PEAK parameter, demonstrating a high correlation between simulated results and actual laboratory tests. This validation underscores the potential of the PEAK parameter as a predictive tool for enhancing the reliability and safety of polypropylene automotive components. The research presented in this article contributes significantly to the field of material science and engineering by providing a deeper insight into the mechanical behavior of polypropylene and introducing an effective tool for predicting crack initiation in automotive components. The findings hold promise for advancing the design and manufacturing processes in the automotive industry, with potential applications extending to other sectors.
Acute Thrombosis Induced by Drug-Coated Balloons Dilation in Neoatherosclerosis Plaque, Successfully Treated with a MicroNet-Covered Stent: A Case Report and Literature Review
Authors: Stefanini Matteo , Maresca Luciano , Ginanni Corradini Luca , Balocco Simone , Rigla Juan , Simonetti Giovanni
Published: July 2024

Background The operator's ability in performing carotid stenting (CAS) has improved clinical outcomes. However, more than 3% of patients need to be treated again after CAS. Most of the cases requiring further intervention are affected by hyperplasia. The recommended procedure is the DEBalloon. On the other hand, the literature reports a small number of carotid neoatherosclerosis cases and is recommended to be treated using elective Micronet-covered stent. Discriminating between the two types of in-stent-restenosis ISR (hyperplasia or neoatherosclerosis) is critical for a positive outcome.Case summary We describe a case in which a patient treated with carotid stenting 8 years before, was diagnosed with ISR. Due to the development of neurological symptoms and progressive increases in Peak Systolic Velocity (PSV) eight years following carotid stenting, a DEBalloon was used in a carotid in-stent-restenosis (ISR) standard procedure. About ten minutes after the procedure, the patient developed hemiplegia consistent with the treated carotid territory. The implantation of a MicroNet-covered stent excluded the thrombus and reverted symptoms with a normal MR control at 24 h. Conclusion This case illustrates that when in-stent stenosis evolves years after the stent implantation, neoatherosclerosis should be assessed, and a MicroNet-covered stent should be considered.
Outcomes of Active Middle Ear Implants: Speech Perception and Quality of Life
Authors: Salamah Marzouqi , Alradhi Athair , Alzhrani Farid , Yousef Medhat
Published: July 2024

Objective: To evaluate audiological outcomes, quality of life, and complications in patients implanted with Active middle ear implants (AMEI). The secondary objective is to investigate the required duration after implantation to reach satisfactory outcomes. Methods: This retrospective study included 31 patients implanted with Active middle ear implants (AMEI) with different methods of floating mass transducer attachment. Patients with incomplete medical records and those who did not respond to postoperative follow-up were excluded. Patients were assessed preoperatively, and at one, three, and six months postoperatively. The assessment included Pure Tone Average (PTA4), Speech Reception Threshold (SRT) and Speech Discrimination Score (SDS). The Speech Spatial and Qualities of Hearing scale (SSQ12) was also used to evaluate levels of satisfaction. Result: There are no significant differences found in PTA and SRT between the 3-, 6-, and 12-month visits. The speech reception threshold (SRT) showed a statistically significant improvement at 3, 6, and 12 months post-operative measures compared to pre-operative. Additionally, the SDS exhibited a significant increase only after 12 months, compared to the 3-month time point. However, satisfaction levels did not significantly differ between the 6-month and 12-month measurements following surgery. Conclusion: Vibrant Sound bridge improves subjective satisfaction scores and audiological test scores in patients with different types of hearing loss. AMEI has a low risk of medical or surgical complications, the ease of using a hearing implant, and the social benefits of good hearing and communication.
The Putative Virulence Plasmid pYR4 of the Fish Pathogen Yersinia Ruckeri Is Conjugative and Stabilized by a HigBA Toxin-Antitoxin System
Authors: Floras Fisentzos , Mawere Chantell , Singh Manvir , Wootton Victoria , Hamstead Luke , McVicker Gareth , Leo Jack C.
Published: July 2024

The bacterium Yersinia ruckeri causes enteric redmouth disease in salmonids and hence has substantial economic implications for the farmed fish industry. The Norwegian Y. ruckeri outbreak isolate NVH_3758 carries a relatively uncharacterized plasmid, pYR4, which encodes both type 4 pili and a type 4 secretion system. In this study, we demonstrate that pYR4 does not impose a growth burden on the Y. ruckeri host bacterium, nor does the plasmid contribute to twitching motility (an indicator of type 4 pilus function) or virulence in a Galleria mellonella larval model of infection. However, we show that pYR4 is conjugative. We also reveal, through mutagenesis, that pYR4 encodes a functional post-segregational killing system, HigBA, that is responsible for plasmid maintenance within Y. ruckeri. This is the first toxin-antitoxin system to be characterized for this organism. Whilst further work is needed to elucidate the virulence role of pYR4 and whether it contributes to bacterial disease under non-laboratory conditions, our results suggest that the plasmid possesses substantial stability and transfer mechanisms that imply importance within the organism. These results add to our understanding of the mobile genetic elements and evolutionary trajectory of Y. ruckeri as an important commercial pathogen, with consequences for human food production.
Evidence for a Pro-inflammatory State of Macrophages from Non-obese Type-2 Diabetic Goto-Kakizaki Rats
Authors: Silveira Amanda Santos de Almeida , Alves Amara Cassandra dos Anjos , Gimenes Gabriela Mandú , Quessada Patrícia da Silva , Lobato Tiago Bertola , Dias Beatriz Belmiro , Pereira Ana Carolina Gomes , Iser-Bem Patrícia Nancy , Pereira Joice Naiara Bertaglia , Hatanaka Elaine , Masi Laureane Nunes , Pithon-Curi Tânia Cristina , Mattaraia Vânia Gomes de Moura , Hirabara Sandro Massao , Crisma Amanda Rabello , Gorjão Renata , Curi Rui
Published: July 2024

Obesity causes insulin resistance (IR) through systemic low-grade inflammation and can lead to type 2 diabetes mellitus (T2DM). However, the mechanisms that cause IR and T2DM in non-obese individuals are unclear. The Goto-Kakizaki (GK) rat develops IR spontaneously and is a model of non-obese T2DM. These rats exhibit hyperglycemia beginning at weaning and exhibit lower body mass than control Wistar rats. Herein, we tested the hypothesis that macrophages of GK rats are permanently in a pro-inflammatory state, which may be associated with a systemic inflammation condition that mimics the pathogenesis of obesity-induced T2DM. Using eighteen-week-old GK and control Wistar rats, we investigated the proportions of M1 (pro-inflammatory) and M2 (anti-inflammatory) macrophages isolated from the peritoneal cavity. Additionally, the production of inflammatory cytokine and reactive oxygen species (ROS) in cultured macrophages under basal and stimulated conditions was assessed. It was found that phorbol myristate acetate (PMA) stimulation increased GK rat macrophage ROS production by 90-fold compared to basal levels. This response was also three times more pronounced than in control cells (36-fold). The production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), tended to be upregulated in cultured macrophages from GK rats under basal conditions. Macrophages from GK rats produced 1.6 times more granulocyte-macrophage colony-stimulating factor (GM-CSF), 1.5 times more monocyte chemoattractant protein-1 (MCP-1) and 3.3 times more TNF-α than control cells when stimulated with lipopolysaccharide (LPS) (p = 0.0033; p = 0.049; p = 0.002, respectively). Moreover, compared to control cells, GK rats had 60% more M1 (p = 0.0008) and 23% less M2 (p = 0.038) macrophages. This study is the first to report macrophage inflammatory reprogramming towards a pro-inflammatory state in GK rats.
Suppressive Effects of β-Hydroxybutyrate Administration on Lipopolysaccharide-Induced Inflammation in Broiler Chickens
Authors: Horiuchi Tae , Furukawa Kyohei , Kikusato Motoi
Published: July 2024

β-hydroxybutyrate (BHB) is generated as one of the ketone bodies in the liver under fasted and hypoglycemic conditions. While BHB is utilized as an alternative energy substrate in extrahe-patic tissues/organs, this ketone body has been reported to exert anti-inflammatory effects via modulating inflammatory signaling cascades. Several bacterial pathogens that originated in hy-gienic litter conditions consecutively threaten chickens, and its harmful constituent, lipopoly-saccharide (LPS), induces intestinal and systemic inflammation. Therefore, the management of inflammation is a significant concern in poultry production. However, the therapeutic effects of BHB on inflammation have yet to be investigated in chickens. This study demonstrated that BHB administration can alleviate LPS-induced inflammation in broiler chickens, and the effects could be dependent on gene expression levels of ketolytic enzymes, BHB dehydrogenase-1 and suc-cinyl-CoA:3-ketoacid CoA transferase, in extrahepatic tissues/organs. This study is the first to show the therapeutic effects of BHB on LPS-induced inflammation in chickens, possibly via an involvement of BHB utilization.
Effect of Organic-Inorganic Mixed Intumescent Flame Retardants on Intumescent Fire-Retardant Coatings
Authors: Ma Liyong , Song Qingfeng , Dong Fang , Yang Hongli , Xia Zihao , Liu Jianlin
Published: July 2024

Expandable graphite (EG) was modified with a charring agent and organic-inorganic hybridised intumescent flame retardants (MEG) were synthesized. This study uses a cone calorimeter (CCT) and a DaqPRO 5300 radiation heat flow meter to evaluate the fire-resistant properties influenced by MEG on intumescent fire-retardant coatings. The impact of MEG on the thermal degradation of these coatings was investigated through the use of thermogravimetric analysis (TGA). The results obtained by CCT demonstrated that the incorporation of MEG markedly diminished the heat release rate and total heat release rate of the coating, in addition to enhancing the char residue compared to coatings with only expandable graphite (EG). Furthermore, TGA results demonstrate that adding MEG increases the weight of the char residue at elevated temperatures, suggesting improved thermal stability. Based on these findings, MEG exhibits a synergistic flame retardant effect when combined with intumescent fire retardant (IFR) systems. This synergy not only improves the flame-retardant properties of the coatings but also enhances their overall thermal stability, making MEG a promising additive for developing more efficient fire-retardant materials. Thus, MEG-modified coatings offer superior protection against fire hazards, highlighting their potential for practical applications in fire safety.
First Hours Care of Hypoxic-Ischemic Encephalopathy: A French Delphi Consensus
Authors: Nguyen Thulan , Manon Michaud , Pierre-Yves Ancel , Paola Sikias , Gauthier Loron , Beatrice Harvey , Elisabeth Lyonnais , Priscille Sauvegrain , Chantry Anne Alice , Isabelle Guellec
Published: July 2024

Introduction: Management of hypoxic-ischemic encephalopathy (HIE) has been the subject of international recommendations. However, some aspects remain within the realm of service practices and appear to vary greatly from one center to another.

Objectives: To achieve a multidisciplinary consensus in France regarding management of HIE newborns that are not covered by international and national guidelines.
Methods: This is a prospective, multicenter study using the Delphi method from April 21, 2021, to July 15, 2021. Perinatal professionals were contacted through professional societies. Participants received a questionnaire in three successive rounds. Each proposal was rated using a Likert scale from 1 (completely disagree) to 8 (completely agree). An item was considered consensual if at least 70% of responses were in agreement or disagreement.
Results: 58 french neonatal professionals participated. A consensus was reached in the first round concerning the use of passive hypothermia in maternity ward, with 84% agreement and to define the target temperature between 35.0°C and 35.5°C at the third round. Regarding hypoglycemia in the delivery room, 79.2% agreed in the first round to correct blood glucose levels below a threshold of
Epigenetic Regulation and Molecular Mechanisms of Burn Injury-Induced Nociception in the Spinal Cord of Mice
Authors: Meszar Zoltan , Erdei Virag , Szucs Peter , Varga Angelika
Published: July 2024

Epigenetic mechanisms, including histone post-translational modifications (PTMs), play a critical role in regulating pain perception and the pathophysiology of burn injury. However, the epigenetic regulation and molecular mechanisms underlying burn injury-induced pain remain insufficiently explored. Spinal dynorphinergic (Pdyn) neurons contribute to heat hyperalgesia induced by severe scalding-type burn injury through p-S10H3-dependent signaling. Beyond p-S10H3, burn injury may impact various other histone H3 PTMs. Double immunofluorescent staining and histone H3 protein analyses demonstrated significant hypermethylation at H3K4me1 and H3K4me3 sites and hyperphosphorylation at S10H3 within the spinal cord. By analyzing Pdyn neurons in the spinal dorsal horn, we found evidence of chromatin activation with a significant elevation in p-S10H3 immunoreactivity. We used RNA-seq analysis to compare the effects of burn injury and forma-lin-induced inflammatory pain on spinal cord transcriptomic profiles. We identified 98 DEGs for burn injury and 86 DEGs for formalin-induced inflammatory pain. A limited number of shared differentially expressed genes (DEGs) suggest distinct central pain processing mechanisms between burn injury and formalin models. KEGG pathway analysis supported this divergence, with burn injury activating Wnt signaling. This study enhances our understanding of burn injury mechanisms and uncovers converging and diverging pathways in pain models with different origins.
Aminopeptidasic Enzymes as Early Biomarkers of Cardiac Surgery-Associated Acute Kidney Injury and Long-Term Events
Authors: Rísquez Chica Noelia , Pereira Elisa , Manzano Francisco , Jiménez Quintana María Mar , Osuna Antonio , Ruiz Fuentes María Carmen , Wangensteen Rosemary
Published: July 2024

Background: Diagnosis of acute kidney injury (AKI) relies on serum creatinine (SCr) changes. This study investigated if urinary aminopeptidases are early and predictive biomarkers of cardiac surgery associated-AKI (CSA-AKI). Methods: Glutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), dipeptidyl peptidase-4 (DPP4), proteinuria, albuminuria, N-acetyl-β-D-glucosaminidase (NAG) and neutrophile gelatinase-associated lipocalin (NGAL) were measured in urine samples from 44 patients at arrival in Intensity Care Unit (ICU) after cardiac surgery. Sensitivity, specificity, positive and negative predictive value for diagnosis of stages 1, 2 and 3 of AKI were analyzed for the highest quartile of each marker. We also studied the relationship with SCr after surgery, 6- and 12-months glomerular filtration rate (GFR) and other long-term events over the next 5 years. Results: GluAp diagnosed the maximal number of patients that developed stage 2 or 3 of AKI, increasing diagnostic sensitivity from 0 to 75 %. Besides, GluAp and DPP4 was related to the decrease in GFR at 6- or 12-months after surgery. Conclusions: Urinary aminopeptidases are a potential tool for the early diagnosis of CSA-AKI, being GluAp the most effective marker for diagnosing stages 2 or 3 of AKI at ICU admission. GluAp and DPP4 serve as predictive biomarkers for the decrease in GFR.
Optimization of Bending Strength in Hybrid Polyester-Wood Powder (Eusideroxylon zwageri) Composite with Variations in Volume Fraction and Fiber Orientation of Wire Mesh
Authors: Syarief Akhmad , Agusniansyah Nursyarif
Published: July 2024

A composite is a material formed from the combination of two or more constituent materials through a non-homogeneous mixture. This research aims to determine the effect of volume fraction and fiber orientation angle of the hybrid polyester-ulin wood powder (Eusideroxylon zwageri)-wire mesh composite on bending strength. The bending test was conducted using ASTM D-790 standard with a three-point bending test method. The composite was made using the hand lay-up method with various compositions of particles and polyester. The results showed that the composition with less ulin wood powder and finer mesh size with a 45° wire mesh angle orientation had the highest bending strength and high deformation capability. The addition of wire mesh did not significantly increase the bending strength but could reduce the effect of decreased deformation capability.
Yoga and Swimming – A Symbiotic Approach with Positive Impact on Health and Athletes’ Performance
Authors: Bucea-Manea-Țoniș Rocsana , (Gheorghe) Andreea Natalia Jureschi , Vasile Luciela
Published: July 2024

Yoga promotes acceptance, compassion, physicality, active postures, mental and emotional awareness, and spiritual benefits. It involves breath techniques, postures, and body locks, maintaining balance and strength. It's based on ethical principles. Beyond simple performance, swimming is a catalyst for overall well-being. Complementarily, yoga serves as an invaluable adjunct for swimmers, enhancing flexibility, strength, and body awareness - a triad essential to aquatic excellence. The confluence of yoga and swimming, particularly through the practice of aqua yoga asanas, presents a new paradigm for both athletes and non-performers alike. Athletes who embrace the harmonious fusion of swimming and yoga unearth the potential for achieving not just athletic mastery but also a more balanced and fulfilling lifestyle. This blend provides a route not only to enhance performance in the water but also to elevate the overall quality of life. We examined the feasibility of incorporating yoga and swimming practice into Romanian subjects' lifestyles, designing a factor analysis in SmartPLS software, based on an online survey. The study assesses the participants' knowledge of yoga's theory and philosophy, as well as their perceptions of the swimming practice's benefits for social and health issues. According to our study, Romanian participants practice yoga and swimming as often as possible to reduce stress, improve concentration for work-related tasks, and improve joint elasticity, balance, and muscular tone. Thus, Yoga and swimming are substitutes for other approaches in prevention and therapy.
A Buffered Local Anesthetic Without Epinephrine: Development, Characterization, and In Vivo Efficacy and Toxicity Analysis
Authors: Uzbelger Feldman Daniel , Laun Billy B. , Patel Chirag , Pande Sonal Vijay , Boddu Sai HS
Published: July 2024

Lidocaine hydrochloride (HCl) 2% with 1:100,000 epinephrine (LW/E) is widely used to prevent pain during dental procedures and has been associated with injection sting, jittering effects, slow onset, and a bitter aftertaste. Since LW/E’s introduction in 1948, no significant modifications have been proposed. This study aims to design and characterize an improved dental lidocaine HCl injectable formulation without epinephrine (LW/O/E) via buffers, sweeteners, and amino acids. LW/O/E injections were prepared with pH and osmolality values of 6.5 – 7.0 and 590-610 mOsm/kg. Using the electronic tongue (ETongue), the LW/O/E injectable formulations were characterized for viscosity, injectability, and taste analysis. The results were compared with the LW/E control. In vivo efficacy and anesthetic duration of the samples were measured through radiant heat tail-flick latency (RHTFL) and hot plate (HP) tests and local toxicity was assessed after a single intra-oral injection in Sprague Dawley rats (SDR). The viscosity and injectability values of the LW/O/E samples were found to be comparable to the LW/E injection. ETongue taste analysis showed an improvement in bitterness reduction of the LW/O/E samples compared to the LW/E formulation. Toxicity studies of samples in SDR showed minor and transient signs of erythema/eschar and edema. Anesthetic duration via RHTFL and HP paw withdrawal latency time in SDR were found to be comparable for the LW/O/E Sample 3A and the LW/E injection (p<0.05). In conclusion, the buffered, higher osmolality and reduced bitterness developed LW/O/E formulation (Sample 3A) could be considered a promising alternative to the LW/E formulation for dental use.
Effect of Gurney Flaps on Non-Planar Wings at Low Reynolds Number
Authors: Traub Lance W
Published: July 2024

The effect of spanwise wing non-planarity, implemented in conjunction with a Gurney flap is presented. Testing was undertaken in a low speed wind tunnel using a rectangular wing with an aspect ratio of 3. The outer 1/3 of the wing was non-planar which took the form of dihedral or a circular arc. A 2% high Gurney flap was implemented such that it could extend over the entire span, or the planar inboard section. Loads were measured using a sting balance. The data shows that non-planarity increases the maximum lift coefficient and the wing’s lift curve slope. Gurney flap lift modulation was enhanced in the presence of non-planarity. The addition of Gurney flaps caused a greater minimum drag coefficient increment for the non-planar wings. The Gurney flaps reduced the lift dependent drag of the wings; however, the minimum drag coefficient was observed to increase. The Gurney flaps reduced the maximum lift to drag ratio (L/D) for the non-planar wings; however, the flat wing showed a small L/D increment with flap addition.
Application of Hydrogeophysical Techniques in Delineating Aquifers for Estimating Groundwater Recharge Potential to Enhance Water Allocation in Groundwater-Dependent Systems, Northern Cape, South Africa
Authors: Baloyi Lucky , Kanyerere Thokozani , Muchingami Innocent , Pienaar Harrison
Published: July 2024

Application of aquifer delineation using hydro-geophysical techniques was conducted in De Aar, the eastern part of the Karoo region, Northern, South Africa. This study is aimed at demonstrating the use of hydrogeophycal techniques in delineating aquifer systems into unconfined and confined to estimate areas and zones likely to control ground-water recharge. An integrated hydrogeophysical approach using vertical electrical resistivity sounding (VES) and ground telluric methods was applied to delineate subsurface structures. Six VES surveys and seven profile surveys were measured using a Wenner array configuration and ground telluric method respectively. VES data was processed using IPI2win software and used to produce a 2D inference of the subsurface electrical resistivity model. The telluric passive surveys were processed through an automated in-built algorithm to generate 2D profile maps while the electric potential difference curve was interpreted with the lithological cross section constructed 2D conceptual model. The VES results showed four significant layers of low (0.9-8.1 Ωm), moderate (22.4-125 Ωm), and high 68-177 Ωm) electrical resistivity values which are suggestive of the different lithological formations. Additionally, the subsurface model from ground telluric methods supported shallow groundwater potential boreholes with the inference of fewer groundwater accumulations below 50 m. These hydrogeophysics results were compared to the drill chip lithological results and both suggested a double-layer aquifer system, which may therefore suggest that recharge estimation needs to be carried out in two different aquifers. The study therefore successfully demonstrated the use of geophysics techniques in delineating aquifer systems, thereby enhancing the identification of potential recharge areas.
On the Theoretical Intuition of Jungian Archetypes and its Logical Extensions
Authors: Penzance Isaac
Published: July 2024

This article considers the status of psychoanalytical archetypes as attitudinal bodies. It possesses the initiative to consider the prerogative that they are situated on, and to develop that into discussing the conditions for an archetype-like body that is derived from Jungian pretenses. As this article operates within the boundaries of the conjecture, it serves instead to cover the potentiality for developments outside of the simple basis of the archetype, which therefore means that it covers a form of guidance instead of specific results. Unlike Jung’s study, which serves in a multitude of sections and draws upon evidential factors of, however generally expressed, ancient civilisations, this article seeks to apply that logic to the purpose of explicating the meaning and potential extensions of the “archetypal dogma”.
The Technologies of Electrochemical Extraction Lithium Process from Lithium-Containing Solutions
Authors: Dong Qingyuan , Gang Haiyin , Xu Jinxiao , Li Zuxiang , Wang Zhongxiang
Published: July 2024

With the rapid development of new energy vehicles and the digital electronics industry, the demand for lithium has surged, necessitating advanced lithium extraction technologies. Electrochemical methods, noted for their high selectivity and efficiency in extracting target ions from liquid sources in an environmentally friendly manner, have become increasingly vital. These methods are versatile, applicable in scenarios such as lithium extraction from saline lakes, mother liquor separation, and lithium enrichment. They include electrochemical deintercalation, electrochemical ion pumps, and electrodialysis, each offering unique benefits and challenges depending on the application context. This review provides a detailed exploration of the research progress in lithium extraction using electrochemical methods and discusses future prospects for these technologies, emphasizing their potential to meet the growing demand for lithium.
Association of Hyperechoic Fetal Bowel with COVID-19 Infection in Pregnancy: A Prospective Cohort Study
Authors: Spina Vincenzo , Palazzetti Pierluigi , Fabiani Cristina , Rago Rocco , Bisogni Francesco , Campanella Lorenzo , Grilli Debora , Schiavi Michele Carlo , Laganà Antonio Simone , Cignini Pietro
Published: July 2024

The goal of the study is to assess the potential correlation between maternal Sars-cov-2 infection , detected three months before the second trimester anomaly scan, and fetal iperecogenicity in order to determine whether or not this could be considered a predictive factor for maternal-fetal complications . The study included 48 pregnant women who did not have any clear maternal or fetal problems. These individuals had an anomaly scan in the second trimester, as well as amniocentesis and fetal cariotyping, and then RT-PCR testing on their placental tissue after birth to rule out transplacental transmission. There have been no reports of fetal abnormalities via amniocentesis or fetal cariotyping. The patients experienced a high rate of spontaneous births (83%). Fetal development problems (2%) and premature delivery (4%) were uncommon, although placental swabs revealed a possibility of viral transmission across the placenta itself. To the best of our knowledge, this is the first observational study to show that detecting isolated intestinal hyperechogenicity during an abnormality scan in fetuses of women infected with Sars-Cov-2 in the previous three months does not appear to be a predictor of poor maternal-fetal outcomes, but may be linked to transplacental virus transmission.
PVC/CNT Electrospun Composites: Morphology, Thermal and Impedance Spectra
Authors: Briesemeister Marcio , Gómez-Sánchez John Alexander , Bertemes-Filho Pedro , Pezzin Sérgio Henrique
Published: July 2024

PVC/CNT membranes were electrospun, and subsequently characterized by thermal analyses (TGA and DSC), transmission and scanning electron microscopies (TEM and FEG) and electrical impedance spectroscopy (EIS). TEM images show that most of the nanotubes were encapsulated, inside the fibers and oriented along them. FEG showed no significant differences in the average diameters. The CNTs caused a significant reduction (up to 20 °C) in the glass transition temperature (Tg) in relation to the resin and a positive impact on thermal stability. Nyquist plots is possible to observe a charge transfer resistance of 38 and 40 Mohm, respectively, for pure PVC and PVC/CNT 3%. It is suggested the high porosity and encapsulation of CNTs in the fibers prevents the formation of a percolation network. The present study aims to evaluate the effect of the encapsulation of CNTs in morphology, thermal and impedance spectra of electrospun composites.