bluuebunny/crossref_metadata_2025 huggingface dataset:
Sokyryntsi Park as the embodiment of the "double life" of the Galagan family
Authors: Ivashko Yulia , Chernyshev Denys , Sandu Ioan Gabriel , Dmytrenko Andrii , Hryniewicz Małgorzata
Published: November 2022

The history and principles of planning the park of the aristocratic country residence of the Galagan family – "Sokyryntsi" are described. Compared to such parks as Oleksandriia and Sofiivka, Sokyryntsi Park is much less well-known, although it is a unique intermediate link between the "official" parks of Classicism-Empire style, such as Oleksandriia in Bila Tserkva and "private" "Ossian parks", as Sofiivka Park in Uman. Although in some sources Sokyryntsi Park with a complex of buildings and structures belongs to the Empire style, but a deeper analysis has shown the simultaneous presence of components characteristic of the "English Landscape Park" and "Ossian Park". The Sokyryntsi ensemble is a unique example in terms of its division into three zones – "parade", "memorial", closed from strangers, and "recreational" on the shores of reservoirs. In addition, this is a rare example of the location directly on the estate of two churches, family crypts and the house of the estate founder. The Sokyryntsi ensemble is a unique example of how the "double life" of the family was subconsciously embodied in the planning and development of the park, where the "parade" part testified to the education of the owners and their role in the Russian Empire, instead, the hidden "memorial" part acted as a "figure of silence" about the shameful deeds of the estate founder. The methods of historical and culturological analysis, method of comparative analysis, method of field surveys with the implementation of dimensional drawings and photofixation were used.
Efficacy and Safety of Tirzepatide in Adults With Type 2 Diabetes: A Perspective for Primary Care Providers
Authors: Kushner Pamela , Anderson John E. , Simon Jörg , Boye Kristina S. , Ranta Kari , Torcello-Gómez Amelia , Levine Joshua A.
Published: November 2022

This article reviews the efficacy and safety data of tirzepatide, a once-weekly, novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP-1) receptor agonist approved in the United States, the European Union, and other regions for the treatment of type 2 diabetes. All doses of tirzepatide demonstrated superiority in reducing A1C and body weight from baseline versus placebo or active comparators. The safety profile of tirzepatide was consistent with that of the GLP-1 receptor agonist class, with mild to moderate and transient gastrointestinal side effects being the most common adverse events. With clinically and statistically significant reductions in A1C and body weight without increased risk of hypoglycemia in various populations, tirzepatide has demonstrated potential as a first-in-class treatment option for many people with type 2 diabetes.
Effectiveness of an Interprofessional Program (Siscare) for Supporting Patients With Type 2 Diabetes
Authors: Bawab Noura , Schneider Marie-Paule , Ballabeni Pierluigi , Locatelli Isabella , Bugnon Olivier , Perraudin Clémence
Published: November 2022

Objective

To assess the effectiveness of an interprofessional support program (Siscare) that includes motivational interviews (patient-pharmacist), electronic monitoring (EM) of medications, patient-reported and clinical outcomes monitoring, and interactions with physicians for patients with type 2 diabetes in French-speaking Switzerland.

Methods

This was a prospective, multicenter, observational cohort study using a hybrid implementation-effectiveness design. Individual daily adherence to at least one oral antidiabetic medication was measured by EM. A global adherence score was estimated by the product of a model-estimated implementation and a nonparametric estimate of persistence over time. Clinical outcomes (A1C, blood glucose, BMI, blood pressure, heart rate, and cholesterol levels) and quality of life (QoL) were analyzed over time using linear mixed-effect models.

Results

A total of 212 patients were included from 27 pharmacies; 120 patients (57%) were followed up for at least 15 months. In total, 140 patients (66%) were male, the mean age was 64 ± 11 years, and the mean number of chronic medications per patient at baseline was 5 ± 3. Of 178 patients who used EM, 95% (95% CI 92–99%) remained persistent at the end of the follow-up period. The percentage of persistent patients taking their medications appropriately (implementation) was stable during follow-up and was estimated to be 90% (95% CI 87–92%) at baseline and 88% (95% CI 84–91%) at month 15. At baseline, the mean A1C and BMI were 7.5% and 31 kg/m2, respectively, which decreased by 0.5% (P = 0.012) and 0.6 kg/m2 (P = 0.017), respectively, after 15 months. QoL remained stable during follow-up.

Conclusion

The program supports medication adherence and improves clinical outcomes, illustrating the overall preventive effect of coordinated care.
Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes
Authors: Yang Diane , Patel Sanjeet , Szlachcic Wojciech J. , Chmielowiec Jolanta , Scaduto Diane , Putluri Nagireddy , Sreekumar Arun , Suliburk James , Metzker Michael , Balasubramanyam Ashok , Borowiak Malgorzata
Published: November 2022

Genetic analysis of an adult patient with an
unusual course of Ketosis-Prone Diabetes (KPD) and lacking islet autoantibodies
demonstrated a nucleotide variant in the 5’-UTR of PDX1, a beta-cell development gene. When differentiated to
the pancreatic lineage, his induced pluripotent stem cells stalled at the
definitive endoderm stage. Metabolomic analysis of the cells revealed that this
was associated with leucine hypersensitivity during transition from the
definitive endoderm to the pancreatic progenitor stage, and RNA-sequencing
showed defects in leucine-sensitive mTOR pathways contribute to the
differentiation deficiency. CRISPR-Cas9 manipulation of the PDX1 variant demonstrated that it is
necessary and sufficient to confer leucine sensitivity and the differentiation
block, likely due to disruption of binding of the transcriptional regulator NFY
to the PDX1 5’-UTR, leading to
decreased PDX1 expression at the early pancreatic progenitor stage. Thus, the
combination of an underlying defect in leucine catabolism characteristic of KPD
with a functionally relevant heterozygous variant in a critical beta-cell gene
that confers increased leucine sensitivity and inhibits endocrine cell
differentiation resulted in the phenotype of late-onset beta-cell failure in this
patient. We define the molecular pathogenesis of a diabetes syndrome and
demonstrate the power of multi-omics analysis of patient-specific stem cells
for clinical discovery.
GC-globulin/vitamin D-binding protein is required for pancreatic α cell adaptation to metabolic stress
Authors: Viloria Katrina , Nasteska Daniela , Ast Julia , Hasib Annie , Cuozzo Federica , Heising Silke , Briant Linford J.B. , Hewison Martin , Hodson David J.
Published: November 2022

GC-globulin (GC), or vitamin D-binding protein, is a multifunctional protein involved in transport of circulating vitamin 25(OH)D and fatty acids, as well as actin-scavenging. In the pancreatic islets, the gene encoding GC, GC, is highly-localized to glucagon-secreting α cells. Despite this, the role of GC in α cell function is poorly understood. We previously showed that GC is essential for α cell morphology, electrical activity and glucagon secretion. We now show that loss of GC exacerbates α cell failure during metabolic stress. High fat diet-fed GC-/- mice have basal hyperglucagonemia, which is associated with decreased α cell size, impaired glucagon secretion and Ca2+ fluxes, and changes in glucose-dependent F-actin remodelling. Impairments in glucagon secretion can be rescued using exogenous GC to replenish α cell GC levels, increase glucagon granule area and restore the F-actin cytoskeleton. Lastly, GC levels decrease in α cells of donors with type 2 diabetes, which is associated with changes in α cell mass, morphology and glucagon expression. Together, these data demonstrate an important role for GC in α cell adaptation to metabolic stress.
Oral Peroxisome Proliferator-Activated Receptor-Alpha (PPAR)-α Agonist Enhances Corneal Nerve Regeneration in Patients with Type II Diabetes Mellitus
Authors: Teo Calesta Hui Yi , Lin Molly Tzu-Yu , Lee Isabelle Xin Yu , Koh Siew-Kwan , Zhou Lei , Goh Dylan Shaoying , Choi Hyungwon , Koh Hiromi Wai Ling , Lam Amanda Yun Rui , Lim Paik Shia , Mehta Jodhbir S. , Kovalik Jean-Paul , Coffman Thomas M. , Tan Hong Chang , Liu Yu-Chi
Published: November 2022

Diabetic corneal neuropathy (DCN) is a common complication of diabetes mellitus (DM). However, there are very limited therapeutic options. We investigated the effects of a peroxisome proliferator-activated receptor-alpha (PPAR)-α agonist, fenofibrate, on thirty patients (60 eyes) with type II DM. On in-vivo confocal microscopy evaluation, there was significant stimulation of corneal nerve regeneration and a reduction in nerve edema after 30 days of oral fenofibrate treatment, evidenced by the significant improvement in corneal nerve fiber density (CNFD) and corneal nerve fiber width, respectively. Corneal epithelial cells morphology also significantly improved in its cell circularity. Upon clinical examination, fenofibrate significantly improved patients’ neuropathic ocular surface status by increasing tear break-up time along with a reduction of corneal and conjunctival punctate keratopathy. Tear substance P (SP) concentrations significantly increased after treatment, suggesting an amelioration of ocular surface neuroinflammation. The changes in tear SP concentrations was also significantly associated with the improvement in CNFD. Quantitative proteomic analysis demonstrated that fenofibrate significantly upregulated and modulated the neurotrophin signalling pathway, linolenic acid, cholesterol and fat metabolism. Complement cascades, neutrophil reactions, and platelet activation were also significantly suppressed. Our results showed that fenofibrate could potentially be a novel treatment for patients with DCN.
Subtherapeutic levels of cefuroxime inside a cannulated pedicle screw used in spine surgery: results from a porcine microdialysis study
Authors: Hvistendahl Magnus A , Hanberg Pelle , Stilling Maiken , Kaspersen Alexander Emil , Høy Kristian , Bue Mats
Published: November 2022

Background and purpose: Minimally invasive spine surgery has continuously evolved for specific surgical procedures and patient populations to lower morbidity and the risk of postoperative bacterial infection. Perioperative antibiotic prophylaxis is an important preventive measure and local tissue concentrations can be quantified with microdialysis. Insertion of spinal implants induces tissue trauma and inflammation, which may affect antibiotic proximate implant concentrations. We compared perioperative cefuroxime concentrations inside a cannulated pedicle screw used in minimally invasive spine surgery with the opposite non-instrumented vertebral pedicle.Materials and methods: Microdialysis catheters were placed inside a cannulated pedicle screw and in the opposite non-instrumented vertebral pedicle of the same vertebra (L1) in 8 female pigs through a posterior lumbar surgical approach. Following a single-dose intravenous cefuroxime administration (1.5 g), dialysates and plasma were dynamically sampled over 8 hours. The primary endpoint was time above the cefuroxime clinical breakpoint minimal inhibitory concentration for Staphylococcus aureus of 4 μg/mL (T>MIC4).Results:  Median T>MIC4 was 0 h (range 0–0) inside the cannulated pedicle screw, 1.6 h (range 1.1–2.4) in non-instrumented vertebral pedicle, and 1.9 h (range 1.9–2.9) in plasma.Conclusion: A single-dose intravenous cefuroxime administration provided low and subtherapeutic concentrations for prevention of infection inside a cannulated pedicle screw in the lumbar spine. Therapeutic concentrations were achieved in the opposite non-instrumented vertebral pedicle up to 1.5–2 h. Therefore, additional prophylactic strategies may be considered in cannulated instrumented spine surgery, especially in high-risk patients. Alternative dosing regimens seem relevant in lumbar spine surgery lasting longer than 1.5 h.
The Effect of Different Intermediary Layer Materials Under Resin Composite Restorations on Volumetric Cuspal Deflection, Gap Formation, and Fracture Strength
Authors: Deger C , Özduman ZC , Oglakci B , Eliguzeloglu Dalkilic E
Published: November 2022

This study investigated the effect of different intermediary layer materials under class II mesio-occluso-distal (MOD) resin composite restorations on volumetric cuspal deflection, gap formation, and fracture strength. In total, 32 sound human maxillary premolars were used. After large, standardized Class II MOD cavities were prepared, a universal adhesive (Clearfil Universal Bond Quick, Kuraray) was applied. The premolars were randomly allocated into four groups according to different intermediary layer materials (n=8): Group Z250 (control)/micro-hybrid composite (Filtek Z250, 3M ESPE); Group EST/low-viscosity bulk-fill resin composite (Estelite Bulk Fill Flow, Tokuyama Dental Corp) + micro-hybrid composite; Group NOV/nanofiber-reinforced low-viscosity composite (NovaPro Flow, Nanova) + micro-hybrid composite; and Group RIB/polyethylene fiber [Ribbond, Ribbond Inc] + micro-hybrid composite. Distilled water was used for storage for 24 hours. Using microcomputed tomography (micro-CT), the teeth were scanned immediately after cavity preparation (T0), then 24 hours after restorative procedures (T1). Volumetric cuspal deflection in cubic millimeters (mm3) was analyzed on the palatal and buccal regions of each restoration individually at T0 and T1 scans. Gap formation (mm3) was evaluated to quantify the volume of black spaces at the tooth-resin interface on the T1 scan. After these scans, using a universal testing machine, the teeth were subjected to a fracture strength test (0.5 millimeters/minute [mm/min]). The fracture surfaces were analyzed with a stereomicroscope. The data were analyzed using the Kruskal-Wallis, one-way analysis of variance (ANOVA), and Dunn’s tests (p< 0.05). No significant differences in volumetric cuspal deflection and fracture strength were detected for all tested groups (p>0.05). Group RIB exhibited significantly higher gap formation values in comparison with all other groups (p<0.05). Predominant failure mode was favorable.
El impacto de la de vacunación en las tasas de contagio, letalidad, defunción y comorbilidad de la covid-19
Authors: Ortiz Lazcano Asael
Published: November 2022

En este artículo se analiza las tasas de crecimiento y de primera categoría de contagio, letalidad y mortalidad del covid-19 en México. El eje de esta investigación postula que a mayor número de vacunas aplicadas contra covid-19, tiene que darse una disminución sostenida en la transmisibilidad y defunciones por esta pandemia. Esta revisión se hizo desde tres momentos en el tiempo, lo que permite conocer un antes y un después de la aplicación de las vacunas en México. Se trabajó con la base Datos Abiertos de la Dirección General de Epidemiología mexicana. Para el cálculo de las tasas de primera categoría se requirió del Censo de Población y Vivienda de 2010 y 2020 y la Encuesta Intercensal 2015 del Instituto Nacional de Geografía y Estadística (Inegi). Para identificar el impacto de las comorbilidades, se hizo una regresión logística binomial que permitió estimar probabilidades de fallecimiento en cada uno de ellos. Entre los resultados se observa que, posterior a la fecha de inicio de inmunizaciones, las tasas de contagio, letalidad y mortalidad de covid-19 en el contexto mexicano presentaron una disminución significativa, lo que demuestra la efectividad de la inmunización. Otro dato importante es que la regresión logística binomial demostró que las comorbilidades siguen generando una mayor propensión a fallecer en las personas que las padecen y se contagian de covid-19.
PENINGKATAN KETERAMPILAN IBU PKK MELALUI PELATIHAN PEMBUATAN SABUN CUCI CAIR DAN SABUN MINYAK JELANTAH
Authors: Setiawati Ina , Widiantie Rahma , Hindiana Anna Fitri
Published: November 2022

Desa Tarikolot merupakan sebuah desa yang berada di daerah perbatasan kabupaten kuningan dengan kabupaten Cirebon. Sebagian besar masyarakat memiliki keterampilan membuat alat-alat kebersihan seperti sapu, sikat, keset dll, sehingga desa tarikolot mendapat julukan desa penghasil alat-alat kebersihan. Perlu adanya peningkatan keterampilan selain membuat sapu, salahsatunya adalah keteampilan membuat sabun pencuci piring bagi ibu ibu PKK di desa Tarikolot agar membantu membuat peluang usaha baru dan meningkatkan pendapatan keluarga. Metode pelaksanaan kegiatan pengabdian masyarakat yang dilakukan meliputi 3 tahapan dianataranya; persiapan, pelaksanaan, evaluasi. Kegiatan persiapan diawali dengan; observasi ke desa tarikolot dan melakukan percobaan sederhana membuat sabun dengan melibatkan mahsiswa. Kegiatan pelaksanaan yaitu dengan melakukan penyuluhan pembuatan sabun pada ibu ibu PKK, serta melakukan sosialisasi produk  sabun yang sudah dibuat kepada warga-warga desa tarikolot. Kegiatan evaluasi dilakukan dengan memberikan angket kepada ibu-ibu PKK yang sudah mendapatkan pelatihan. Manfaat dari kegiatan pengabdian masyarakat ini adalah masyarakat diharapkan ibu ibu PKK memiliki keterampilan membuat sabun serta membuka peluang usaha baru yang dapat menambah pendapatan keluarga.
Digitalisasi Promosi Produk UKM Bunga hiasan “Rosy” Melalui Website Dalam Upaya Meningkatkan Penjualan
Authors: Widaningsih Sri , Mustikasari Ati , Rahim Abdurrahman
Published: November 2022

Usaha Kecil Menengah (UKM) seringkali masih menggunakan media konvensional untuk memasarkan produk-produk yang dihasilkannya, termasuk dalam hal ini UKM Bungahiasan.Rosy yang terletak di Kota Bandung, Jawa Barat. Sejauh ini, UKM Bungahiasan.Rosy memanfaatkan media sosial untuk memasarkan produk-produk handcraft yang dihasilkannya. Namun sayang, UKM Bungahiasan.Rosy belum memiliki website, padahal website merupakan unsur yang cukup penting untuk memasarkan produk-produk UMKM secara digital. Dalam kegiatan pengabdian masyarakat ini, tim membuat website untuk digunakan oleh UKM Bunga Rosy. Dengan adanya website ini diharapkan dapat meningkatkan penjualan produk-produk yang dihasilkan oleh UKM Bungahiasan.Rosy
Penggunan gaya bahasa repetisi dalam film animasi anak-anak di channel youtube nussa official
Authors:   Universitas Muhammadiyah Pringsewu, Diana Ani , Suherman Suherman ,   Universitas Muhammadiyah Pringsewu, Tussalekha Rohmah ,   Universitas Muhammadiyah Pringsewu
Published: November 2022

Penelitian ini bertujuan untuk mendeskripsikan gaya bahasa repetisi dalam film kartun animasi di channel youtube Nussa Official. Penelitian ini merupakan penelitian deskriptif kualitatif. Data penelitian berupa paparan kalimat dari hasil transkripsi film kartun animasi di channel youtube Nussa Official yang mengandung gaya bahasa repitisi. Adapun teknik pengumpulan data dalam penelitian ini menggunakan metode simak, dan selanjutnya metode untuk analisis data menggunakan padan ortografis. Hasil analisis dan pembahasan dapat diketahui bahwa dalam tayangan film animasi anak di youtube channel Nussa Official banyak digunakan gaya bahasa repetisi, yaitu: epizeuksis terdapat 5 kutipan, anafora 6 kutipan, epistrofa 5 kutipan, simploke (syimploke) 4 kutipan¸ mesodiplosis 4 kutipan, epanalepsis 5 kutipan, dan anadiplosis 4 kutipan. Simpulan dalam penelitian ini adalah bahwa penggunaan gaya bahasa repetisi yang memiliki fungsi untuk menekankan atau mempertegas pesan-pesan yang akan disampaikan berupa nilai-nilai pendidikan yang islami melalui tayangan film kartun animasi anak di channel youtube Nussa Official
ANALISIS KARAKTERISTIK TANAH MENGGUNAKAN METODE MAGNETIK DAN X-RAY FLUORESCENCE DI KECAMATAN OHEO
Authors: Sulaiman Al Faathir Rasyid , Anda Pou , Haraty Syamsul Razak
Published: November 2022

Tanah adalah benda alam yang memiliki kemampuan dalam menyediakan unsur hara. Jika tanah kekurangan unsurhara maka akan mempengaruhi pertumbuhan dan perkembangan tanaman. Unsurhara mikro adalah unsur yang memiliki sifat kemagnetan yang tinggi dari unsure lainnya, sehingga dalam menganalisis tingkat kesuburan tanah dapat menggunakan metode Suseptibilitas Magnetik. Penelitian ini telah dilakukan di Kecamatan Oheo, Kabupaten Konawe Utara, pengambilan sampe lterdiri 2 stasiun dengan topografi yang berbeda. Setiap stasiun terdiri atas 6 titik sampel dengan kedalaman 20, 40, dan 60 cm dan jarak antar titik sampel 100 m. Sampel tersebut kemudian diolah menggunakan instrumen MS2B dan XRF. Hasil pengukuran suseptibilitas magnetik yang tinggi berada di stasiun 1 topografi berbukit memiliki nilai suseptibilitas magnetik(χLF) berkisar 604,3–3414,5(10-8 m3/kg). Sedangkan stasiun 2 topografi datar memiliki nilai suseptibilitas magnetik (χLF) berkisar antara 109,8–342,6(10-8m3/kg). Hasil pengukuran XRF menunjukkan kedua stasiun tersebut masih kekurangan unsur hara mikro Co dan unsur Fe melebihi kadar konsentrasi yang diinginkan. Stasiun 1 memiliki nilai χFD (%) yang menunjukkan 75% mengandung bulir super paramagnetik, sedangkan stasiun 2 terlihat beberapa titik hanya 10% mengandung bulir super paramagnetik. Sehingga dapat dikatakan bahwa stasiun 1 telah mengalami penurunan kesuburan.
Pengolahan Potensi Desa untuk Memajukan Perekonomian Desa Tirtohargo Kabupaten Bantul
Authors: Adyantari Api
Published: November 2022

Desa mempunyai keunikan dan laba yang mampu dikembangkan menjadi peluang di desa. Peluang potensial di desa berupa banyak hal, salah satunya adalah pertanian dan pariwisata. Desa Tirtohargo mempunyai lahan yang luas untuk mengembangkan pertanian dan memiliki konservasi hutan mangrove yang dapat digunakan sebagai objek wisata. Tujuan dari jurnal ini adalah untuk mengajak pembaca dalam membuka wawasan tentang potensi yang dapat dimanfaatkan di Desa Tirtohargo. Jurnal ini menggunakan metode studi pustaka yang mengacu pada jurnal-jurnal ilmiah dan artikel terkait untuk mendukung hasil diskusi yang akan tercapai. Hasil program KKN ini berupa pendidikan bagi masyarakat, terutama masyarakat Desa Tirtohargo tentang bagaimana memproses produk pertanian hortikultura menjadi produk makanan dan banyak dipromosikan. Hasil pertanian hortikultura adalah dolar yang diproses ke dalam keripik bawang. Selain itu, keberadaan kawasan konservasi hutan mangrove dapat digunakan sebagai potensi objek wisata yang dapat mempertinggi pendapatan dan kesejahteraan masyarakat Desa Tirtohargo. Kesimpulan jurnal tersebut adalah bahwa Desa Tirtohargo memiliki potensi yang dapat dikembangkan di sektor pertanian serta tarik wisata. Selain itu, potensi ini mengoptimalkan media sosial sebagai bentuk promosi ke publik.
ВЛИЯНИЕ ТРЁХСТУПЕНЧАТОГО ФУНКЦИОНАЛЬНОГО КОМПЛЕКСА БИОЛОГИЧЕСКИ АКТИВНЫХ ДОБАВОК НА ВСАСЫВАТЕЛЬНУЮ ФУНКЦИЮ ТОНКОГО КИШЕЧНИКА У СОБАК С ПРИЗНАКАМИ МАЛЬНУТРИЦИИ
Authors: Ушакова Татьяна
Published: November 2022

В статье рассмотрены вопросы характера изменений всасывательной функции тонкого отдела кишечника у собак при комплексной коррекции мальнутриции с использованием трёхступенча-того функционального комплекса биологически активных добавок. Изучены показатели клинического и нутритивного статуса больных животных, установлено влияние трёхступенчатого функционального комплекса биологически активных добавок на уровень всасывательной функции кишечника.
MODERN VIEW ON METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS
Authors:   N.P. Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russia, Samoshkina E.S. , Balykova L.A. ,   N.P. Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russia, Shirokova A.A. ,   N.P. Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russia, Krasnopol’skaya A.V. ,   N.P. Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russia, Soldatov O.M. ,   N.P. Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russia,   Mordovian Republican Children’s Clinical Hospital, Saransk, Republic of Mordovia, Russia, Urzyaeva L.N. ,   N.P. Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russia
Published: November 2022

This bibliographical review presents the current data on the metabolic syndrome (MS) in children and adolescents, the criteria for its diagnosis and associated arterial hypertension, the role of genetic factors and lifestyle characteristics in the formation of MS. The main sequence links of pathogenesis were also considered, as follows: insulin resistance and compensatory hyperinsulinemia, the systemic nature of inflammation in adipose tissue, endothelial dysfunction and activation of the renin-angiotensin-aldosterone system with involvement of the extraglomerular apparatus of the kidneys in the process, hypersympathicotonia, the influence of the overweight factor in mother during pregnancy, nutritional characteristics of children in the first 2 years of life coupled with the Vitamin D deficiency, male gender. The treatment tactics with an emphasis on non-drug methods was observed as well.
FACTORS INFLUENCING ADHERENCE TO AND PREVALENCE OF BREASTFEEDING: RESULTS OF AN ONLINE SURVEY OF MOTHERS IN RUSSIA (PART 1)
Authors:   People’s Friendship University of Russia, Moscow, Russia, Ukraintsev S.E. ,   Nestlé Rossiya, Moscow, Russia, Ovsyannikov D.Yu. ,   People’s Friendship University of Russia, Moscow, Russia, Schepkina E.V. ,   Russian Presidential Academy of National Economy and Public Administration (RANEPA), Moscow, Russia,   "Techdepartment," LLC, Khimki, Moscow Oblast, Russia
Published: November 2022

The purpose of the research was to identify the reasons for the insufficient prevalence of breastfeeding (BF), to determine the ways to increase the prevalence of BF in Russia based on the data obtained during an online survey of mothers of children in the first 6 months of life, which was conducted in two stages in 2020-2022. 1981 mothers from different age groups living in Russian cities with population from 100 thousand to 1 million and more participated in the study. Results: the most significant negative impact on the prevalence of exclusive breastfeeding (EBF) was the age of mothers of less than 20 years old (p=0.041 compared with mothers of 26 to 30 y/o), completed secondary education compared to higher education (p=0.012 and 0.021, respectively), mother's full-time employment (p=0.001 vs. mothers on maternity leave), marital status (for unwed mothers vs. married p<0.001), gestational age 38 to 39 weeks (p=0.032, 0.004 and 0.0038 compared with 39 to 40, 40 to 41, and 41 to 42 weeks of gestation, respectively), as well as recommendations at the stage of antenatal consultation “to take infant formula with you” to the maternity hospital, “just in case” (p<0.001 compared to no such recommendation). Conclusion: recommendations are given that can contribute to an increase in the prevalence of BF in Russia taking into account the data obtained during the survey.
PELATIHAN PENGEMBANGAN TEMA KREATIVITAS BAGI GURU PAUD GERBANG HARAPAN KECAMATAN BAE KUDUS
Authors: Sucipto Sucipto , Hidayati Richma
Published: November 2022

Penentuan tema sangat terbuka artinya satuan PAUD dapat menentukan tema yang akan digunakan dalam pembelajaran sesuai denga minat anak, situasi dan kondisi lingkungan, serta kesiapan guru mengelola kegiatan. Penentuan tema tidak sekedar mudah diterapkan tetapi perlu memperhatikan beberapa prinsip agar pembelajaran yang dilaksanakan lebih menarik dan mendalam. Keluasan tema tergantung dari kemampuan guru dalam menguasai tema tersebut. Hal penting yang harus diperhatikan guru dalam mengembangkan tema adalah kebermaknaan tema dalam membangun pengalaman belajar yang bermutu bagi anak usia dini. Karenanya dalam menentukan tema menjadi penting bila diawali dengan identifikasi tema dan sekaligus ketertarikan anak terhadap topik tertentu. Pembelajaran anak usia dini dapat dikembangkan dengan menggunakan tema. Melalui tema pembelajaran, peserta didik akan lebih mudah mengenal suatu konsep pengetahuan dan dapat mempelajari sesuatu yang bersifat konkrit. Dengan demikian, indikator perkembangan anak dapat tercapai secara optimal.
Optimasi Online Marketing Menggunakan Dynamic e-Commerce pada CV Noor Mandiri Rotan
Authors: Handayani Putri Kurnia , Latifah Noor , Muzid Syafiul
Published: November 2022

Online Marketing is a marketing system that uses internet media as a vehicle for marketing products. One type of marketing through the internet is buying and selling marketing, known as e-commerce. Dynamic e-commerce technique is a technique used in e-commerce websites that utilizes business intelligence in managing consumer spending patterns. The type of website used by CV Noor Mandiri Rattan so far is the introduction of marketing type, where the website only contains a business profile and several product catalogs owned so that the CV Noor Mandiri Rattan can be said to lag behind technological updates or use internet marketing techniques that are lagging behind. Seeing this, the Muria Kudus University service team helped in optimizing online marketing that has been owned by CV Noor Mandiri Rotan using dynamic e-commerce so that it can serve sales transactions and expand market share and increase company revenue.
Organogénesis directa e indirecta a partir de segmentos nodales, hojas y raíces de Eugenia involucrata DC
Authors: Bustamante Karina , Rocha Sandra Patricia , Sharry Sandra Elizabeth , Guerra Miguel Pedro , Niella Fernando Omar
Published: November 2022

Eugenia involucrata DC. (Myrtaceae), es un árbol nativo de Argentina, Brasil, Paraguay y Uruguay, con importante potencial económico. Su propagación y conservación están limitados por la característica recalcitrante de sus semillas, siendo el cultivo de tejidos un método eficiente para estos fines. En este trabajo se evaluó el efecto del tipo de explante y distintas combinaciones de reguladores de crecimiento vegetal, BAP, TDZ y ANA en la formación de brotes adventicios, enraizamiento y formación de plántulas de E. involucrata. Se desarrollaron tres experimentos: inducción, diferenciación de brotes y aclimatización en invernáculo de las plántulas obtenidas. Las hormonas BAP y TDZ indujeron callos y brotes a partir de segmentos nodales, radiculares y foliares. El máximo porcentaje de formación de brotes por organogénesis directa se obtuvo en segmentos nodales cultivados en medio MS ½ con 2,25 mg/L de BAP y la máxima frecuencia de formación de callos se obtuvo en explantos nodales o radiculares cultivados en medio MS ½ con TDZ, solo o combinado con ANA. La máxima formación de brotes adventicios, por organogénesis indirecta, se obtuvo en segmentos nodales, inducidos en medio MS ½ con 1,1 mg/l de TDZ+0,93 mg/l de ANA y subcultivados en medio MS ½ con 0,5 mg/l de TDZ +1 g/l de carbón activado. Los ápices de los brotes obtenidos a partir de organogénesis directa e indirecta enraizaron in vitro en medio MS ½ libre de RCV formando plántulas que luego se aclimataron en invernáculo, demostrando un alto porcentaje de supervivencia a los seis meses de trasplante.
Otra vuelta a "Roland Barthes y los límites del estructuralismo": Gramática y función referencial en Paul de Man
Authors: Pérez Fajardo Daniel
Published: November 2022

En el contexto del auge de la semiología francesa, Paul de Man intenta animar una polémica contra Roland Barthes por medio de un texto que no es admitido para su publicación. A pesar de su fracaso editorial, el texto posee un gran valor tanto para el estudio del estructuralismo, como para interpretar la obra de Paul de Man. En efecto, en este ensayo Paul de Man presenta argumentos que lo distancian del pensamiento estructural de Barthes y que tematizarán su obra posterior. Este ensayo busca revisar los reparos que Paul de Man manifiesta en relación a Barthes y cómo el desarrollo de estas disidencias teóricas da cuenta de la influencia de Kenneth Burke sobre el crítico belga.
"Donde dije, digo". Cortázar y la corrección política
Authors: Barea Federico
Published: November 2022

Este ensayo revisa el antiperonismo cortazariano a partir de una lectura del breve texto “Donde dije digo”, prácticamente desconocido para el público en general y aparecido en la revista Índice de España en 1973. Esta práctica de exhumación permite volver a leer bajo otra luz una serie de relatos saturados de intervenciones críticas (“Casa tomada”, “Las puertas del cielo” y “La banda”) con la cual sería posible reabrir la dimensión política de la obra de Cortázar, en particular su conflictiva vinculación con el peronismo y con la potencialidad del significante “pueblo”.
“Algo como un sí, o un siempre y un ahora”. Tópicos del habeas vox en la palabra política de Cortázar sobre la desaparición de personas
Authors: Gómez Susana
Published: November 2022

Este trabajo presenta algunas reflexiones en relación con los discursos de Cortázar en defensa de los derechos humanos en Argentina durante el período de la última dictadura cívico-militar. Se analiza cómo Cortázar habla como un escritor exiliado cuya palabra ya es considerada como autorizada para hablar de la desaparición forzada de personas por motivos políticos. El análisis de los discursos pronunciados ese año emblemático de 1981 es posible con apoyo en las nociones de habeas corpus y de habeas vox, útiles para dar a conocer el esfuerzo del escritor –en sucesivos foros internacionales– por crear un discurso creíble en relación con el horror de los desaparecidos.
Sindrom Hiperperfusi Serebral
Authors:   Faculty of Medicine Anesthesiology and Intensive Care Universitas Padjadjaran Bandung, Indonesia, Yulianti Bisri Dewi
Published: November 2022

Sindrom hiperperfusi serebral (cerebral hyperperfusion syndrome/CHS) adalah kondisi yang relatif jarang terjadi setelah endarterektomi karotis (carotidenarterectomy/CEA) atau stenting arteri karotis (carotid artery stenting/CAS) tetapi berpotensi dapat dicegah. Empat kriteria berikut untuk mendefinisikan CHS pasca-CEA: (1) Kejadian dalam waktu 30 hari pasca-CEA; (2) Fitur klinik seperti onset baru sakit kepala, kejang, hemiparesis, dan skala koma glasgow (GCS) <15 atau fitur radiologis termasuk edema serebral atau perdarahan intraserebral (ICH); (3) Bukti hiperperfusi (didefinisikan sebagai aliran darah serebral [CBF] >100% dari nilai perioperatif) pada studi pencitraan atau tekanan darah sistolik >180 mmHg; dan (4) Tidak ada bukti iskemia serebral baru, oklusi karotis pasca operasi dan penyebab metabolik atau farmakologis. Faktor kunci pada patofisiologi CHS adalah gangguan autoregulasi dan disfungsi baroreseptor, hipertensi kronis, mikroangiopati dan sawar darah otak, pembentukan radikal bebas, derajat beratnya carotid stenosis kronis dan sirkulasi kolateral. Faktor kunci dalam pencegahan dan pengobatan CHS adalah pengendalian tekanan darah, waktu dilakukan operasi karotid, obat-obat anestesi yang digunakan. Penggunaan profilaksis obat anti-epilepsi tidak dianjurkan. Bukti tentang penggunaan salin hipertonik dan manitol tidak kuat tetapi dapat diberikan jika pasien mengalami edema serebral, kortikosteroid dan barbiturat tidak diindikasikan. Hiperventilasi dan sedasi dapat diberikan jika pasien mengalami edema serebral
Surface Treatments of Natural Fibres in Fibre Reinforced Composites: A Review
Authors: Seisa Keolebogile , Chinnasamy Vivekanandhan , Ude Albert U.
Published: November 2022

The use of natural fibres in fibre-reinforced composites comes with drawbacks. They are highly hydrophilic, leading to high moisture absorption and poor interfacial adhesion in matrix-reinforcement bonds. This affects the fibres’ thermal stability as well as mechanical properties, hence limiting their wider application. This paper reviewed different ways in which natural fibres have been treated to improve hydrophobicity, reinforcement-matrix interfacial adhesion and thermal stability. It will investigate. among others, treatments like alkali, acetylation, bleaching, silane, benzoylation and plasma, which have been found to improve fibre hydrophobicity. The literature reviewed showed that these methods work to improve mechanical, chemical, and morphological properties of natural fibres by removing the amorphous surface, thus allowing for more efficient load transfer on the fibre-matrix surface. Studies in the literature found alkali treatment to be the most common surface modification treatment due to its simplicity and effectiveness. However, plasma treatment has emerged due to its lower processing time and chemical consumption. A comparative analysis of other improved properties was also investigated.
Removal of Heavy Metals from Aqueous Solutions with the Use of Lignins and Biomass
Authors: Miros-Kudra Patrycja , Sobczak Paulina , Kopania Ewa
Published: November 2022

The overproduction of pollutants resulting from the development of industry causes the deposition of large amounts of toxic and carcinogenic substances, including heavy metals, in the aquatic ecosystem and other ecosystems. This is a civilisation problem of the present times, posing a serious threat to the natural environment, including humans. For this reason, it has recently become extremely important to develop effective methods to minimise the concentration of heavy metal ions in the aquatic systems and thus reduce their negative impact on the environment. One such technique is adsorption, which is believed to be an effective method of removing contaminants such as heavy metal ions from aqueous solutions. Looking at the available literature of the last few years, it can be concluded that adsorbents of natural origin are becoming more and more important. These are agricultural waste, all kinds of biomass, and waste from various industries. The study attempts to present and evaluate the sorption capacity of materials of natural origin, including oat bran, chitosan, alginate, tree bark, coconut fibre, and lignin. The use of such biosorbents is more friendly for the environment compared to their synthetic counterparts and perfectly fits the concept of sustainable development and the circular economy.
Artificial Neural Network-based Prediction Technique for Waterproofness of Seams Obtained by Using Fusible Threads
Authors: Karabay Gulseren , Senol Yavuz , Ozturk Hasan , Mesegul Cansu
Published: November 2022

The aim of this study was to estimate waterproofness values of seams composed of the combination of fusible threads and antiwick sewing threads through artificial neural networks (ANN). Fusible threads were used to obtain waterproof seams for the first time. Therefore, estimating the value of the waterproofness variable with the help of models created from test values can contribute to accelerating the progress of further studies. Hence, ten different samples were prepared for two fabrics, and the waterproofness values of the seams obtained were tested using a Textest FX 3000 Hydrostatic Head Tester III. For the prediction of waterproofness values of the seams, the Levenberg-Marquardt backpropagation algorithm was used for artificial neural network pattern models with sigmoid and positive linear transfer functions. Finally, the ANN model was successful in estimating the waterproofness of the seams. The highest correlation coefficient was R = 0.95081 which indicated that the prediction made by the neural network model proved to be reliable.
Coefficients for Assessing the Visibility of Materials Used in Anti-Smog Face Masks
Authors: Brochocka Agnieszka , Owczarek Grzegorz , Szkudlarek Joanna
Published: November 2022

The application of phosphorescence for the modification of face mask materials is motivated by the need to appreciably increase their visibility while using graphical elements with a relatively small area. Phosphorescent dyes absorb part of the visible spectrum while emitting radiation at wavelengths that are longer than the absorbed ones. Thus, a phosphorescent substance can emit light even if it is not being illuminated at a given time (but was before). This paper describes studies of the optical properties based on parameters such as the reflectance coefficient, chromaticity coordinates, as well as luminance measured from digital images for two models of smog-protective face half-masks differing in terms of their inner layer with filtration properties and outer printed layer. The external surface of one mask type is printed with a phosphorescent solid star pattern, while the other with a phosphorescent open star pattern. The influence of the inner filter layer was assessed in correlation with the colour of the outer layer and the type of printing. Moreover, the phenomenon of phosphorescence was identified. The study resulted in developing a material with properties providing better visibility under defined use conditions.
Influence of the Structure of Low MolecularWeight Esters on Poly(lactic acid) in the Plasticization Process - part 1
Authors: Gzyra-Jagieła Karolina , Sulak Konrad , Draczyński Zbigniew , Kiełbik Longina Madej , Jagodzińska Sylwia , Borkowski Dominik
Published: November 2022

Polymers derived from renewable sources which are additionally subject to degradation processes are currently an interesting alternative to conventional polymers of petrochemical origin. One of such polymers is poly(lactic acid) (PLA), which can be used in the packaging, textile and also medical industries. Its great advantage is the susceptibility to biodegradation and the nontoxicity of the degradation products. Because of high brittleness and stiffness, the modification of PLA is necessary to improve its plastic deformability, which can expand the new application possibilities. As part of the research work, the modification of PLA by plasticisation was undertaken to improve its plastic deformability properties. The low molecular mass esters from the citrate group and glycerol triacetate were used. The samples extruded from plasticised polymer were characterised using Differential Scanning Calorimetry (DSC) and Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC). The mechanical properties and melt flow rate after modification were determined. The aim of the research was to determine the relationship between the structure of a plasticiser and its ability to reduce the interactions in the polymer chain in order to develop an optimal polymer-plasticiser arrangement. Based on this research, there was no relationship between the efficiency of the plasticisation process and the increasing molecular mass of the plasticiser. The additional chemical (acetyl) group in the plasticiser also does not increase the efficiency of the PLA plasticisation process. In the next steps of the research, functional forms will be produced, i.e. fibers, films, and fittings from the selected polymer-plasticiser systems.
Vietnam’s Commitments Under the European Union – Vietnam Investment Protection Agreement (EVIPA): Some Noteworthy Points
Authors: Binh Ha Thi Thanh
Published: November 2022

The Investment Protection Agreement among Vietnam, the European Union (EU) and each of the EU’s member states (EVIPA) was signed by Vietnam and the EU on June 30, 2019, in Ha Noi. While the Free Trade Agreement between Vietnam and the EU (EVFTA) promotes trade liberalization between Vietnam and EU countries, EVIPA establishes legal safeguards for outward investment activities of investors from EU countries into Vietnam and vice versa. The EVIPA has not yet come into effect as it needs to be approved not only by the EU Council and the National Assembly of Vietnam, but also by the Parliaments of all EU’s member states. Even so, with the EVFTA in place, Vietnam hopes to attract more investment from the EU as Vietnam has committed to provide investors from the EU with certain protection some of which have not been available in any other investment protection agreements to which Vietnam is a party. Investors with EU nationalities undoubtedly are interested in how Vietnam could implement its commitments under the EVIPA. The paper discusses key commitments of Vietnam under the EVIPA along the lines of relevant provisions of Vietnam law and addresses some noteworthy points for investors from the EU planning to invest in Vietnam. It argues that understanding how domestic law and regulations facilitate international commitments would help investors from the EU prepare for their investments in Vietnam.
Real Property in Chinese Civil Law – The Process of Developing Property Legislation
Authors: Mai Le Thi Ngoc
Published: November 2022

January 1, 2021 marks an extremely important event in China’s legislative history, as the day the first Civil Code of the Democratic People’s Republic of China entered into force on May 28, 2020 (the “Chinese Civil Code 2020”), after an extremely long preparation time. The 2020 Chinese Civil Code was considered China’s “Declaration of Civil Rights”, with a huge number of regulations. Understanding legal provisions of the Chinese Civil Code is essential because of the following reasons: firstly, as Vietnam’s neighboring country, China has close relations with Vietnam in many areas of civil life. Secondly, Civil Code is a fundamental law of social life, having a profound influence, so the study of Civil Code should be given priority before studying many other laws. Thirdly, researching laws of other countries will help us realize the points that need to be improved in our laws. Up to now, legal research on this Code has not been much. Despite the prolonged lockdown in the past two years, China’s real estate market is hotter than ever. Real estate is an extremely important asset, especially when the future of other economic sectors is bleak, the society’s financial resources were pouring more and more into real estate, from which relevant conflicts were also increasing, requiring the constant improvement of legal regulations. This study aims to analyze the process of improving Chinese civil law provisions on real property and assess the completion level of the current regulations. To achieve these goals, the study has collected a large number of relevant regulations that China has promulgated and legal discussions of experts. The article is composed of three parts. The first is an overview of real property legislation before the Chinese Civil Code 2020, and the second part is the current regulations. Based on them, the author reports research findings and makes discussion.
Mito y naturaleza en “Aranmanoth” de Ana María Matute
y “Ekomo” de María Angüe Nsue
Authors: KANGA Akissi Agnès Danielle
Published: November 2022

The writing of myth in Aranmanoth by the Spaniard Ana María Matute and Ekomo by the
Equatoguinean María Angüe Nsue aims to present the importance of nature in a different
point of view. Although these writers belong to different geographical and cultural areas,
their works come together to place nature at the centre of human concerns.
The ironic background of cultural and mythical patterns
in the 20th-century novel Saul Bellow:
characters of the 50s and the 60s
Authors: ROBU Valentina
Published: November 2022

Although Bellow’s novels deal with huge suffering as a rule, very often a duplicitous ironic
approach can be detected in the structure of his books and in the configuration of his main
characters. The perspective of psychological torment and frailty in Herzog or Mr.
Sammler’s Planet is combined with the awareness of an ailing and unusually large body in
Henderson the Rain King. This article explores the subtle ironic narrative background in
two of his novels and highlights the use of cultural references and mythical allusions as key
devices in the construction of characters for which the exercise of suffering is almost a
vocation.