bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbiomes in Phytotherapeutics: Pros and Cons
Authors: Fatima Hijab , Yasmin Azra
Published: December 2023

This chapter highlights the significance of microbiomes especially plant
microbiomes in the field of therapeutics. The Plant microbiome comprises epiphytes
and endophytes inhabiting the surface as well as inside of the tissues of the host. These
microbial communities occupy a well-defined habitat and perform various activities
developing certain interactions with the host such as commensalism, mutualism, and
parasitism. For the establishment and functioning of the plant microbiome, plant root
releases exudate according to the nutritional requirement of particular microbial
species. In response to the stimulus, microbes chemotactically move towards the roots,
colonize and move to other parts of the plant. Microbes also adopt certain mechanisms
not only to colonize and multiply in specific hosts but also to promote the growth of the
host by secreting various plant growth hormones and exopolysaccharides. The
numerous compounds produced by microbes make plants tolerant of biotic and abiotic
stresses. The microbial communities in plant microbiome have an active role in
maintaining the health, ecology and physiology of the host. As a major portion of the
world’s population is dependent on phytotherapeutic medicines according to the World
Health Organization, the pharmacological characteristics of major medicinal plants
such as Aesculus hippocastanum and Ginkgo biloba are described in detail. This
chapter highlights the significance of the core role of the microbiome associated with
plants in the synthesis of various medicinal compounds. The phytotherapeutic potential
of plant microbiome revealed that endophytes and epiphytes isolated from various plant
species showed great potential for the production of antimicrobial as well as antiinflammatory
substances. The medicinally rich compounds such as antibacterial
proteins, phenols, saponin glycosides, flavonoids, terpenoids, carbohydrates and fatty
acids isolated from plant-associated microbes have various applications in the
treatment of fetal diseases and also exhibit anti-inflammatory action. Certain public
concerns are raised about the side effects of medicinal plants used in phytotherapeutics.
A relevant case study about public concerns along with preventative measures such as
rigorous testing is provided in this chapter.
Probiotic Bacteria and Plants
Authors: Shahbaz Muhammad , Ali Jawad , Naeem Hammad , Murtaza Shamas , Raza Nighat , Farooq Umar
Published: December 2023

Probiotics are microorganisms, when consumed, give health benefits due to
improvement in the activity of gut microflora. Various health claims are associated
with probiotics e.g. modulation of the immune system, mitigation of lactose
intolerance, protection from infections and maintenance of healthy gut microflora.
They have also been demonstrated to be helpful in treating a wide range of illnesses,
including cancer, inflammatory bowel syndrome, diarrhea brought on by antibiotics,
and infantile diarrhea. Streptococcus, Bacillus, Enterococcus, Escherichia coli,
Bifidobacterium, Lactobacillus, and several strains of the fungus Saccharomyces are
significant probiotic bacterial genera. In fibrous parts of plants and probiotic bacteria,
the bacteriocins play a major synergistic antimicrobial role. Prebiotics are nondigestible
plant materials i.e., complex carbohydrates, fermented in the colon, thus
yield short chain fatty acids and energy, and enhance the growth of probiotics. Inulin
and fructans are important plant prebiotics. The indirect health benefits of prebiotics
are immunomodulatory characteristics, mineral absorption, cancer prevention, and
modulation of the metabolism of gut flora, and the prevention of constipation and
diarrhea. Many fruits, tuber crops, root crops as well as vegetables contain a huge
reservoir of prebiotic carbohydrates. The function of probiotic microbes in foods
includes modulation of the immune system, normalization of gastrointestinal activity,
and the inhibition of the growth of pathogenic microbes and harmful metabolites. The
function of prebiotic food material is to promote the growth of healthy bacteria in the
intestinal tract. This chapter highlights the potential need of probiotics and prebiotics in
our diet, and it also discusses their health benefits, mode of action, sources, food
applications, distinct types, and future perspectives.
Carbon Nanostructures and Medicinal Plants
Authors: Shanker Kalakotla , Raut Sushil Y. , Reddy Tamatam Sunilkumar , Pa Divya , Dhanabal S.P. , Apryatina Kristina
Published: December 2023

It has been a decade since the widespread usage of carbon nanostructures

(CNSs) in biomedical research. A few examples are the use of CNSs in medication, for

protein administration and in instruments to provide nucleic acids to treat cancer and

other chronic diseases. The near-infrared optical characteristics of CNSs allowed them

to be used in diagnostics and in non-invasive and very sensitive imaging equipment. In

recent years, the scientific and industrial sectors have paid increasing attention to the

physical and chemical properties of various nanomaterials. Structure, electronics,

water, and more may all be derived from them. This chapter will focus on carbon

nanomaterials and related nanostructures, which are designed to give the most up-t-

-date research results. There is a broad acceptance of traditional medicine in many

societies, with over 60 percent of the world's population and over 80 percent of the

population in developing countries depending on medicinal plants for medical reasons.

Among the many reasons for this are the ease of use, affordability, and low cost. It is

believed that nanotechnology will play a significant role in medicinal plant research

and drug delivery in the near future. These nano-drug delivery devices may boost the

activity of medicinal plants, but also solve some of their limitations. Nanocarriers

aiding in the treatment of cancer, diabetes, and other life-threatening illnesses by

delivering herbal chemicals will also be discussed in this chapter.
A Comprehensive Study of State-of-the-Art App- lications and Challenges in IoT, and Blockchain Technologies for Industry 4.0
Authors: Zahoor Saniya , Akhter Ravesa , Vishwarupe Varad , Bedekar Mangesh , Pande Milind , Bhatkar Vijay P. , Joshi Prachi M. , Pawar Vishal , Mandora Neha , Kuklani Priyanka
Published: December 2023

The Internet of Things (IoT) is a network of smart and self-configuring
devices that exchange data by interacting with the environment to make decisions
without human intervention. Endowed to sense surrounding events, these physical
objects generate large amounts of real-time data that need an acceptable architecture
with better security to process and convert it into meaningful information.
Implementation of blockchain in IoT offers a secure, transparent and efficient
mechanism to store and manage data generated by connected IoT devices. Even though
the integration of blockchain with IoT is pretty recent, there are at present a huge
number of applications that include smart healthcare, smart homes, e-government,
automotive industry, smart education, precision agriculture etc. However, there are
several challenges encountered in Blockchain-IoT integration which include
anonymity, standardization, interoperability, heterogeneity, data privacy, smart
contracts, legal issues, transparency, storage capacity and scalability, security, etc. This
chapter presents the current state-of-the-art Blockchain-IoT integration in order to
examine how blockchain could possibly improve the IoT ecosystem catered towards
Industry 4.0. This chapter investigates the various application domains of Blockchain-IoT integration. It also discusses the main challenges faced in the adoption of
blockchain in IoT environments for I4.0
Designing a Human-centered AI-based Cognitive Learning Model for Industry 4.0 Applications
Authors: Vishwarupe Varad , Zahoor Saniya , Akhter Ravesa , Bhatkar Vijay P. , Bedekar Mangesh , Pande Milind , Joshi Prachi M. , Patil Avinash , Pawar Vishal , Mandora Neha
Published: December 2023

The aim of this chapter is to focus on the status of data mining approaches
for e-learning and identify the gaps in them. It is seen that a predominant work has
been done in e-learning through data mining techniques such as educational
recommenders, association rules, clustering, profile-based approaches, personalization,
prediction techniques, and decision support systems. However limited work is done on
e-learning from a cognitive science perspective, which gives us the motivation to work
in this field. The proposed work aims at proposing a cognitive model for e-learning
systems using data mining for Industry 4.0 applications which shall usher in a new
datum for e-learning in cyber-physical systems.
Integrating Internet of Things (IoT), Machine Learning (ML), and the Cloud Infrastructure to Monitor Driving Behavior for Usage-based Insurance in the Indian Context
Authors: Wawage Pawan S. , Deshpande Yogesh D.
Published: December 2023

Although Usage-Based-Insurance has a wide range of applications, it is
practically nonexistent in India. We have done research to help design a system that
combines IoT, ML, and cloud to help us overcome this problem as a next step. The
goal is to create a machine learning model for the cloud that will allow us to calculate
driver and customer safety scores based on where and how the car has been driven. We
were able to do this by evaluating information from our smartphone's sensors. Utilizing
this data and classification system, problems like Usage-Based-Insurance can
subsequently be resolved in the real world (UBI). Usage-based insurance has proven to
be efficient and appealing to both insurers and the ones insured in a wide range of
countries. The use of this method is sparse to nonexistent in India, but it is on the
horizon. As a result, there is a lot of potential for our research and suggested works on
UBI in India.
Chemical Fingerprints of Medicinal Plants - HPTLC Profiling
Authors: Balkrishna Acharya
Published: December 2023

Chemical Fingerprints of Medicinal Plant- HPTLC Profiling gives an overview of the use of high-performance thin-layer chromatography (HPTLC) for profiling medicinal herbs. Starting with an introduction to HPTLC the book guides the reader through HPTLC instrumentation and laboratory application. Additional notes on the stationary HPTLC phases and hyphenating HTPLC with other analytical techniques are also provided. The book concludes with an exhaustive list of HPTLC fingerprints of many herbs that can be used in medicinal preparations. The book outlines a scientific approach to the identification and selection of herbs for preparing traditional medications. By reading this book, learners will be able to 1) understand the basics of HPTLC, 2) learn how to use the instruments for lab analysis and 3) quickly identify chemical fingerprints of important medicinal herbs.

Key Features

- A concise overview of HPTLC and associated techniques

- A Step-by-step guide to performing HPTLC analysis

- Full color illustrations

- An exhaustive list of HPTLC fingerprints for 108 medicinal plants, with botanical names

- An appendix of TLC solvent systems and reagents for different phytochemical compounds and secondary metabolites

- Simple language for easy understanding

- Detailed bibliography

Chemical Fingerprints of Medicinal Plant- HPTLC Profiling is an essential handbook for scholars in analytical chemistry, plant science and traditional medicine who want to understand the application of HPTLC techniques for research and development in phytomedicine.
Upaya Framing Stop Funding Hate Terhadap Isu Pembentukan Sentimen Rasisme Oleh Media Di Inggris Tahun 2016-2018
Authors:   Brawijaya University, Nafisa Auli , Triarda Reza ,   Brawijaya University
Published: December 2023

Inggris adalah salah satu negara yang menerima imigran dan pencari suaka dimana jumlahnya mencapai angka yang signifikan dari berbagai negara. Meningkatnya imigran di Inggirs memunculkan xenophobia di Inggirs dan meningkatkan rasisme yang disebabkan oleh pemberitaan pers dan media di Inggris. Media-media tersebut memunculkan retorika kebencian terhadap imigran yang menciptakan sentimen rasisme pada imigran. Isu pembangunan sentimen rasisme menjadi permasalahan yang dilakukan oleh tiga media besar di Inggris yang paling banyak menciptakan sentimen rasisme, yaitu The Sun, Daily Mail, dan Daily Express. Diskriminasi ini kemudian memunculkan gerakan perlawanan bernama Stop Funding Hate pada 2016 yang bertujuan untuk mengajak dan engage dengan perusahaan-perusahaan untuk melakukan ‘ethical advertising’ dengan menarik dan mencegah periklanan. Untuk mendeskripsikan upaya yang dilakukan oleh gerakan ini, artikel ini menggunakan konsep strategi Framing oleh Jurgen Gerhards. Aksi gerakan ini membawa hasil positif dengan adanya penarikan iklan sentimen rasisme, permintaan maaf oleh pihak media, hingga pemutusan kerjasama perusahaan dengan tiga media besar tersebut.
Questioning the Kantian Propositions: Explaining the Role of the United States as Democratic Peace Model in 21st Century
Authors:   Brawijaya University, Kusumadewi Hemalia
Published: December 2023

Theorizing and manifesting peace through democracy has always been connected with Kantian propositions, making a country's attempt in realizing those two not to be separated with Kantian theories also. The United States of America has been self-proclaimed as a ‘role model and promoter of democracy and peace’. To some extent this might be true, as its foreign policy key objective includes ‘promoting democracy and advocating human rights. However, the ‘role model’ also translates as an entity that needs to be ‘the best’, yet the 2021 Capital Riot reflects otherwise. This paper proposes the Kantian Peace Triangle as the framework to do the work, by breaking-down US’s policy and activities particularly in the Post-Cold War period. The paper uses qualitative approach and literature review method in the research. This paper argues that the US has not been able to reach the ‘ideal’ essence as a ‘role model of democracy and peace’ in the global order, and that this role has become mostly irrelevant in the 21st century world
PENGARUH BEBERAPA JENIS DAN DOSIS FUNGISIDA TERHADAP PENYAKIT HAWAR DAUN (Helminthosporium sp.) DAN KEANEKARAGAMAN JAMUR ENDOFIT PADA DAUN TANAMAN JAGUNG (Zea mays L.)
Authors: Safitri Helvira Agita , Martosudiro Mintarto , Choliq Fery Abdul
Published: December 2023

Penelitian ini bertujuan untuk mengetahui pengaruh aplikasi/perlakuan beberapa jenis fungisida pada dosis yang berbeda terhadap keanekaragaman jamur endofit dan intensitas penyakit hawar daun (Helminthosporium sp.) pada jagung. Kegiatan penelitian dilaksanakan pada bulan Oktober 2022-Desember 2022 di kebun percobaan PT. BASF, Agrotechnopark Universitas Brawijaya. Berdasarkan hasil penelitian yang telah dilakukan, dapat diketahui bahwa perbedaan dosis yang diaplikasikan sangat berpengaruh terhadap keanekaragaman jamur endofit pada daun tanaman jagung. Hasil penelitian menunjukkan bahwa nilai keanekaragaman jamur endofit yang tertinggi yaitu pada perlakuan epoxiconazole+ pyraclostrobin dengan dosis 750 ml/ha dan difenoconazole dengan dosis 2000 ml/ha. Aplikasi dosis fungisida yang berbeda berpengaruh terhadap keanekaragaman jamur endofit. Bahan aktif epoxiconazole+pyraclostrobin dan difenoconazole mampu menekan perkembangan jamur patogen tanaman tanpa mempengaruhi perkembangan jamur endofit yang terdapat pada daun tanaman jagung. Dosis fungisida terbaik dalam menekan serangan penyakit hawar daun yaitu pada perlakuan difenokonazole (3000 ml/ha).
Sanctity and quality as the conceptual basis of the value of life doctrine in the bioethical discourse
Authors: Horban Oleksandr , Martych Ruslana
Published: December 2023

The article offers a study of the bioethical discourse regarding the value of life through the prism of conceptualizing the main approaches to the study of this phenomenon. It is noted that with all the diversity of approaches that demonstrate a wide range of views on the value of life, the modern bioethical discourse com-bines the ideas of scientific research, the dogmatics of religious doctrines and the basic principles of moral imperatives, which are interpreted in a civilized soci-ety in the context of medico-biological problems of life preservation and repro-duction, as well as determining its value. This combination is far from being ec-lectic. It synthesizes the main achievements of scientific, religious and ethical thought and extrapolates them to the problem of human life, which is a unique phenomenon that should be separated into a specific system of moral norms and imperatives of human activity. The article notes that in modern conditions the bioethical discourse is concentrated around the axiological paradigm in the study of living beings. All the diversity of viewpoints is proposed to be grouped into two main approaches: the ethics of the sacredness (sanctity) of life and the the quality of life ethics. The conceptualization of these two main approaches permits to consider all the diversity of views on the value of life in the context of bioethi-cal discourse as a systematized set of views, which contributes to the creation of an appropriate scientific research situation and will contribute to the deepening of scientific studies on the specified subject.
Marian Stroński i jego prace dla kościoła salezjanów w Przemyślu
Authors: Winiarska Katarzyna
Published: December 2023

Many people contributed to the realization of the Salesian church of St Joseph in Przemyśl: builders, craftsmen, and artists. Among them was Marian Stroński (1892¬1977), one of the chief painters of Przemyśl of the 2nd and 3rd quarter of the 20th century. He completed several commissions for the church whose neo-Gothic shape and slender tower became part of the city's panorama. From 1926 to 1927, in the presbytery, Stroński worked on the polychrome according to the design by Mario Ceradini and contributed two paintings for the main altar: The Holy Family and The Death of St Joseph. Twenty years later he was commissioned to create subsequent paintings for side altars: Mary Help of Christians and The Sacred Heart of Jesus which replaced the canvases from 1926 by another Przemyśl painter, Franciszek Hałun. The new altars with the paintings were consecrated in 1946 and 1947.
Combined pathogenetic therapy of erectile dysfunction
Authors: Krasnyak S. S. , Efremov E. A.
Published: December 2023

Introduction. Erectile dysfunction (ED) is a common condition that reduces the quality of life of numerous men. Therefore, optimising treatment protocols is always a challenge.

Objective. To evaluate the efficacy of "Edelim®" for pathogenetic therapy for erectile dysfunction.

Materials and methods. The study included 67 men (40 – 65 years old) with ED. The patients were divided into two treatment groups: the main group received tadalafil 5 mg PO o.d. + “Edelim®”, the control group received tadalafil 5 mg PO o.d. only. As effectiveness criteria anthropometric studies were used, IIEF-5 scale, metabolic profile blood tests, and systemic endothelial function was assessed.

Results. Over 12 months of therapy, the IIEF-5 score increased by 28.2% in the main group and by 10.3% in the control group. After 12 months in the main group total cholesterol, LDL, triglycerides decreased by 14.8%, 10.7% and 13.9% respectively. The reactive hyperaemia index after 3, 6 and 12 months increased by 6.6%, 10.9% and 22.0%, respectively. In the control group these indices did not change significantly. The main group showed a stable decrease in body mass and waist circumference by an average of 2.6% and 3.8% respectively after 12 months. In the control group, body mass did not change significantly.

Conclusion. Some patients require combination therapy to address metabolic risk factors and disorders, despite the high efficacy of PDE-5 inhibitors in improving erection quality. “Edelim®” is the first product created specifically for long-term combined pathogenetic therapy of ED with metabolic disorders.
Features of the course of bronchial asthma in patients who have suffered a new coronavirus infection
Authors: Kiseleva N. V. , Tarlovskaya E. I. , Boldina M. V.
Published: December 2023

Objective: to evaluate the clinical status of patients with bronchial asthma in the post-Covid period depending on the severity of the acute period of COVID-19. Materials and methods: a case-control study was conducted of patients diagnosed with asthma who had suffered a coronavirus infection, who turned to the Nizhny Novgorod Regional Pulmonology Center for consultation about asthma. The analysis included 56 patients. The survey methods included two stages: retrospective and prospective. The following scales were assessed: the severity of asthma, the level of asthma therapy, asthma control according to the Global Initiative for Asthma (GINA), and the severity of shortness of breath (mMRC test). Results: the analysis revealed statistically significant differences on all scales, regardless of the severity of the acute course of COVID-19, p <0.005. In the process of data analysis, depending on the severity of the acute period of infection, statistically significant differences in the clinical status before and after COVID-19 were found in patients with mild and moderate coronavirus infection. In patients who had mild COVID-19, clinical status indicators worsened on all scales: asthma severity before COVID-19 ─ 2.00 [2.00–2.00], after COVID-19 ─ 2.00 [2.00–3.00], р<0.005; control according to GINA before COVID-19 ─ 2.00 [2.00–2.00] after COVID-19 ─ 3.00 [2.00–3.00]; step therapy before COVID-19 ─ 3.00 [2.25–3.00], after ─ 4.00 [4.00–5.00], р<0.005; severity of shortness of breath before COVID-19 ─ 1.00 [0.25–1.00], after COVID-19 ─ 2.00 [1.00–2.00], р<0.005. Patients who had moderate COVID-19 also worsened all indicators of clinical status on all scales: severity of asthma before COVID-19 ─ 2.00 [2.00–2.00], after COVID-19 ─ 2.00 [2,00–3.00], p<0.005; control according to GINA before COVID-19 ─ 2.00 [2.00–2.00], after COVID-19 ─ 3.00 [2.00–3.00]; level of therapy before COVID-19 ─ 3.00 [3.00–3.00], after COVID-19 ─ 4.00 [4.00–5.00], p<0.005; severity of shortness of breath before COVID-19 ─ 1,00 [1.00–1.00], after COVID-19 ─ 2.00 [1.00–2.00], p<0.005. Conclusion. еhe results of our study demonstrate the negative impact of SARS-CoV-2 on the clinical status of patients with asthma who have suffered a new coronavirus infection.
Features of changes in the heart, blood vessels and internal organs in men with hypertension, depending on the value of the body mass index
Authors: Tikhomirova N. Yu. , Eliseeva L. N. , Zhdamarova O. I. , Malkhasyan I. G.
Published: December 2023

Objective: study of the features of changes in the heart, blood vessels and internal organs (liver and kidneys) in men with hypertension, depending on the BMI value. Materials and methods: 194 men aged 25 to 63 with hypertension were examined. All the examined patients were divided into 3 groups depending on the BMI value. All patients included in the study were determined by serum creatinine (calculated by GFR), glucose, aspartate aminotransferase, alanine aminotransferase, lipid spectrum, uric acid. In addition, echocardiography, ultrasound of the kidneys with measurement of arterial and venous blood flow through the main vessels of the kidneys, ultrasound of the liver were performed. In the future, the groups were compared with each other according to the studied laboratory and instrumental data. Results: as the BMI values increased, the indicators of alanylaminotransferase, IFDS, RWT LV, MMLV, IMLV, the size of the right lobe of the liver, the incidence of hepatosteatosis significantly increased. Adherence to antihypertensive therapy in the selected groups ranged from 18,9 to 20,5%. Bilateral disorders of outflow through the renal veins were 1,8 times more common among people with normal BMI compared with obesity (p<0.05). Conclusion: among the examined young men with hypertension, there are features of an unfavorable "cardiological" profile and low adherence to antihypertensive therapy, which, as the age and length of the disease increases, is associated with a high risk of developing associated clinical conditions in the future. In male patients with hypertension and obesity, the incidence of hepatosteatosis is 100%, having an additional adverse effect on cardiovascular risk. The revealed features of renal venous blood flow among patients with hypertension deserve further investigation.
Evaluation of the effectiveness of the use of iron carboxymaltosate in late pregnancy and in the postpartum period
Authors: Bartsits M. K. , Safronenko A. V. , Gantsgorn E. V. , Umansky M. N.
Published: December 2023

Objective: to evaluate the effectiveness of the use of iron carboxymaltosate in late pregnancy and in the postpartum period. Materials and methods: dynamic observation of the effectiveness of iron carboxymaltosate in 46 pregnant women diagnosed with anemia, latent iron deficiency due to the lack of positive dynamics against the background of taking oral forms of iron preparations, complaining of palpitations, shortness of breath with minimal physical exertion, weakness. The assessment was carried out by the level of hemoglobin (Hb), ferritin a month after the treatment with a high-dose iron preparation intravenously drip. The follow–up period is the third trimester of pregnancy, 2 days after delivery, a month after delivery. Results: the treatment with iron of carboxymaltosate led to an increase in the Hb level of 18±3 g/l, the ferritin level of 70±35 mcg/l a month after the infusion, and an improvement in the clinical condition. Conclusion: the use of iron carboxymaltose in the late stages of pregnancy allows to quickly normalize and maintain target values of hemoglobin and ferritin levels for a long time, already during the postpartum period, as well as improve the quality of life of women.
Evaluation of markers of apoptotic processes and peroxide oxidation of lipids of the mitochondrial fraction of the liver of animals carrying Lewis epidermoid carcinoma at different stages of the development of the tumor process with the introduction of organotin compounds with a tread fragment
Authors: Alhusein-Kulyaginova M. S. , Dodokhova M. A. , Agarizaeva S. Z. , Starostin S. I. , Klimova L. Y. , Silin N. S. , Gulyan M. V. , Shpakovsky D. B. , Milaeva E. R. , Kotieva I. M.
Published: December 2023

Objective: to evaluate changes in markers of apoptotic processes and lipid peroxidation (POL) by accumulation of malondialdehyde (MDA) in the mitochondrial fraction of the liver of animals carrying Lewis epidermoid carcinoma at different stages of the tumor process with the introduction of bis-(3,5-di-tert-butyl-4-hydroxyphenyl)dimethylolol thiolate (Me-3) and (3,5-di-tert-butyl-4-hydroxyphenyl)triphenylololate (Me-5). Materials and methods: the work was performed using laboratory animals - female mice of the C57Bl line/6. 48 hours after the Lewis epidermoid carcinoma strain was transplanted, substances Me-3 and Me-5 were administered once a day for 5 days intraperitoneally at the maximum effective dose of 375 mg/kg and 250 mg/kg, respectively. Animals of the control group were injected with a carrier in similar modes and volumes. Results: when Me-3 was administered at the maximum effective dose on days 7 and 21, a decrease in the level of all the studied indicators was noted, which indicates a high actioxidant activity of a hybrid organotin compound containing one tin-containing [-Sn(CH3)2] and two protective antioxidant fragments (3,5-di-tert-butyl-4-hydroxyphenyl). The compound Me-5 has a more pronounced prooxidant potential, as evidenced by high levels of damage to mitochondrial DNA (8–hydroxy–2'–deoxyguanosine) and malonic dialdehyde. Conclusion: the introduction of bis-(3,5-di-tert-butyl-4-hydroxyphenyl)dimethylolol (Me-3) and (3,5-di-tert-butyl-4-hydroxyphenyl)triphenylolol (Me-5) compounds revealed a change in the pro/antioxidant state and the launch of apoptotic processes in liver cells.
COVID-19 National Football League (NFL) Injury Analysis: Follow-Up Study
Authors: Puga Troy B , Schafer Joshua , Thiel Grace , Scigliano Nicholas , Ruan Tiffany , Toledo Andres , Agbedanu Prince N , Treffer Kevin
Published: December 2023

Background

In 2020, COVID-19 spread across the world and brought normal daily life to a halt, causing the shutdown of nearly everything in order to prevent its spread. The National Football League (NFL) similarly experienced shutdowns and the resulting effects, leaving athletes unable to train in some of the most advanced facilities with many of the best trainers in the world. A previous study, titled COVID-19 Return to Sport: NFL Injury Prevalence Analysis, determined that there was increased injury prevalence during the 2020 season, likely due to decreased physiological adaptations within athletes’ bodies as a result of facility shutdowns. Understanding injury epidemiology is vital to the prevention of injuries and the development of return-to-play protocols.

Objective

The objective of this study is to perform a follow-up study to COVID-19 Return to Sport: NFL Injury Prevalence Analysis in order to examine the longitudinal effects of the COVID-19 pandemic on injury epidemiology. This study examines if there was a recovery to baseline levels of injuries or if there are still lingering effects from the COVID-19 pandemic–induced spike in injuries.

Methods

To determine if there was change in the number of injuries for each season, injury tallies collected from the 17-week-long 2018, 2019, and 2020 NFL regular seasons were compared with those from the 18-week-long 2021 and 2022 NFL regular seasons. A Kruskall-Wallis test with post hoc Dunn analysis was conducted to compare the rate of injuries per team per week between each of the 2018, 2019, 2020, 2021, and 2022 regular seasons.

Results

The Kruskall-Wallis test revealed an H statistic of 32.61 (P<.001) for the comparison of the injury rates across the 5 seasons. The post hoc Dunn analysis showed that 2020 had a statistically significant difference when compared with each of the 2018 (P<.001), 2019 (P=.04), 2021 (P=.02), and 2022 (P=.048) seasons. The 2019 season showed no statistical significance when compared with the 2021 (P=.23) and 2022 (P=.13) seasons.

Conclusions

The results of this follow-up study, combined with the previous study, show that extended training interruptions stemming from COVID-19 in 2020 induced detraining and led to increased injuries. Additionally, the results of this study show that retraining can occur, resulting in the development of injury protective factors, as injury rates returned to baseline levels after 2020. This is the first large-scale and long-term opportunity to demonstrate the effects of these principles and how they are important to understanding injury epidemiology.
Assessing the Labeling Information on Drugs Associated With Suicide Risk: Systematic Review
Authors: Jeon Soo Min , Lim HyunJoo , Cheon Hyo-bin , Ryu Juhee , Kwon Jin-Won
Published: December 2023

Background

Drug-induced suicide (DIS) is a severe adverse drug reaction (ADR). Although clinical trials have provided evidence on DIS, limited investigations have been performed on rare ADRs, such as suicide.

Objective

We aimed to systematically review case reports on DIS to provide evidence-based drug information.

Methods

We searched PubMed to obtain case reports regarding DIS published until July 2021. Cases resulting from drugs that are no longer used or are nonapproved, substance use, and suicidal intentions were excluded. The quality of each case report was assessed using the CASE (Case Reports) checklist. We extracted data regarding demographics, medication history, suicide symptoms, and symptom improvement and evaluated the causality of DIS using the Naranjo score. Furthermore, to identify the potential suicidal risk of the unknown drugs, we compared the results of the causality assessment with those of the approved drug labels.

Results

In 83 articles, we identified 152 cases involving 61 drugs. Antidepressants were reported as the most frequent causative drugs of DIS followed by immunostimulants. The causality assessment revealed 61 cases having possible, 89 cases having probable, and 2 cases having definite relationships with DIS. For approximately 85% of suspected drugs, the risk of suicidal ADRs was indicated on the approved label; however, the approved labels for 9 drugs, including lumacaftor/ivacaftor, doxycycline, clozapine, dextromethorphan, adalimumab, infliximab, piroxicam, paclitaxel, and formoterol, did not provide information about these risks.

Conclusions

We found several case reports involving drugs without suicide risk information on the drug label. Our findings might provide valuable insights into drugs that may cause suicidal ADRs.
Reddit and Dermatology: A Content Analysis of Online Communication on the DermatologyQuestions Subreddit (Preprint)
Authors: Kulkarni Vishnutheertha , Gamsarian Vahram , Varghese Jeffrey , Grewal Tjinder , Lio Peter , Prabhu Arpan
Published: December 2023

BACKGROUND

NA

OBJECTIVE

NA

METHODS

NA

RESULTS

NA

CONCLUSIONS

NA
Virtual Care Adoption During the COVID-19 Pandemic: Digital Resilience in Pain (Preprint)
Authors: Lau Brenda , Abreu Emmanuel , Singh Neha , Venkatarama Tameus , McParland Aidan , Xin Zhang Kai , Brass Justin , Sluka Dorina
Published: December 2023

BACKGROUND

The COVID-19 pandemic has required a rapid transformation in healthcare delivery, prompting a shift from traditional in-person services to digital platforms.

OBJECTIVE

This comprehensive review explores the transition of CHANGEpain Clinic, a community-based pain clinic, to online services. Examining the challenges, benefits, and implications for patient care and accessibility, the paper delves into the experiences of patients and providers. It highlights the role of digital health in improving accessibility, overcoming geographical barriers, and necessitating behavioural changes for effective online interactions.

METHODS

Key themes and insights from a qualitative analysis provide a nuanced understanding of digital transformation's impact on pain management services.

RESULTS

The transition to online services at the CHANGEpain Clinic was marked by a significant increase in virtual appointments, with some services witnessing up to a 300% surge.

CONCLUSIONS

This paper provides a nuanced understanding of the impact of digital transformation on pain management services to create an evidence-based discussion.
The Application of Conceptual Metaphor in English Vocabulary Teaching
Authors: Ma Lixia , Jin Jing
Published: December 2023

As the basic unit of expression, vocabulary is the foundation of English and is closely related to students’ overall language ability. However, many teachers tend to teach English vocabulary in traditional way, simply listing words with little attention to context in daily instruction. As a result, students mechanically memorize words without understanding the connotation and extension of words, which frequently leads to misunderstandings in vocabulary comprehension and inflexible vocabulary application. To solve this problem, this study considers cognitive linguistics as the guide to exploring vocabulary teaching based on conceptual metaphor. Following the definition, mechanism, and classification of conceptual metaphor, it makes an overview of both the international and Chinese studies concerning the application of conceptual metaphor in English vocabulary teaching, and finds that the lack of empirical research, the small sample size, the short time of experiment, the uncomprehensive research results and students’ different ability to accept this teaching method remain to be further solved. This contributes to the existing problems in vocabulary teaching and cultivating students’ competence in cognitive acquisition.
WHAT DOES THE WHO OWE TO CLASSICAL MUSIC?
Authors: Komatović Nikola
Published: December 2023

The interplay between classical and popular music has been a well-documented phenomenon. The British rock band The Who initially embarked on their musical journey in the 1960s as part of the "British Invasion" without many distinctive elements that set them apart. However, a transformation began as the decade drew to a close, and they achieved commercial acclaim.This paper delves into The Who's second and third stages of their career (1970s and 1980s), marked by the creation of pioneering rock operas like "Tommy" and "Quadrophenia." While the term "opera" in the context of popular music may not align with classical opera conventions, it becomes evident that classical music elements found their way into The Who's repertoire.Examining their harmonic structure reveals a fusion of classical influences, albeit in an altered form, enriching their sound. Additionally, The Who's compositions exhibit a nuanced understanding of musical form, further blurring the lines between classical and popular music.Furthermore, this exploration extends beyond classical music to encompass modern and postmodern elements in The Who's oeuvre, notably the subtle hints of minimalism. This paper aims to shed light on the intricate relationship between classical and popular music, using The Who's evolution as a prime example of how a rock band can draw from classical traditions while incorporating elements of contemporary music, ultimately redefining the boundaries of musical genres.
Notas del 3er Congreso Mundial de Ballenas Jorobadas, Santo Domingo, República Dominicana, 2023
Authors: Rodríguez-Jerez Yira A
Published: December 2023

No necesita de un resumen.
Concentración de radionucleidos en algunos hongos basidiomicetos silvestres del Monumento Natural Loma Isabel de Torres
Authors: Binet-Álvarez Andri , Santos-Mella Francisco , Sánchez Vásquez Junior , Tavárez Martínez Vinicio Argenio , Fermín Fernández Manuel Enrique , Paino Perdomo Omar
Published: December 2023

Los hongos juegan un papel importante en la movilidad y acumulación de sustrato, y pueden utilizarse para determinar los niveles de concentración de radionucleidos en el medio ambiente. Este estudio muestra la diversidad de radionucleidos presentes en el suelo del Monumento Natural Loma Isabel de Torres en algunos hongos basidiomicetos silvestres. Los radionúclidos se determinaron con un espectrómetro gamma de Germanio Hiper Puro GX5019 con analizador de espectro digital DSA 1000, utilizando el software Genie 2000. Los organismos analizados fueron Ramaria sp., Sparassis spathulata, Russula sp. y Boletus sp. La actividad específica se obtuvo para cada uno de los basidiocarpos y su respectiva muestra de sustrato circundante. Además, se calculó el factor de bioacumulación. En los hongos se detectaron 137Cs y 40K, mientras que no se encontraron 232Th, 226Ra ni 210Pb. Las muestras de suelo tomadas a mayor altura presentaron una mayor concentración de 226Ra. Con base en estos hallazgos, se recomienda continuar el trabajo en esta línea de investigación.
Una caracterización de los determinantes de la oferta laboral de la población de origen extranjero en la República Dominicana año 2017
Authors: Rodríguez Núñez Juan Bautista , Méndez Cabrera Joel Gabriel
Published: December 2023

Este estudio analiza la influencia de diversas variables en la probabilidad de empleo de inmigrantes en la República Dominicana, utilizando modelos de regresión logística por bloques. Los resultados revelan que factores como el género, la nacionalidad, el nivel educativo, el estatus legal, la geografía, el grupo etario y las razones de migración tienen efectos marginales significativos en la probabilidad de empleo.
Impacto potencial de un acuerdo de cielos abiertos entre los EE. UU. y la República Dominicana
Authors: Vásquez Harold , Vidal José
Published: December 2023

En el último año, la República Dominicana ha mostrado interés en firmar acuerdos de cielos abiertos con sus principales socios comerciales y turísticos. En este estudio, utilizando técnicas de datos de panel, estimamos el impacto de los acuerdos de cielos abiertos (ACA) en el volumen de tráfico aéreo entre los países de América Latina y los Estados Unidos, con el objetivo de comprender el impacto de estos acuerdos en la región. A partir de estas estimaciones, asumiendo que un ACA entre la República Dominicana y los Estados Unidos tenga un impacto similar al promedio regional, calculamos que el ACA podría aumentar el número de vuelos procedentes de los Estados Unidos desde 28,934 (cifra del año 2022) hasta aproximadamente 35,900 vuelos anuales, al igual que incrementar la llegada de pasajeros no residentes en unos 600,000 visitantes adicionales. En general, un ACA entre Estados Unidos y la República Dominicana incrementaría los ingresos por turismo desde los Estados Unidos alrededor de un 24 %, equivalente a unos 746.2 millones de dólares adicionales.
Foreign language vocabulary development: media–driven learning in the informal context
Authors: Balenovic Katica , Prorokovic Jakov
Published: December 2023

This study explored the impact of informal learning on the acquisition of English idioms, operating under the assumption that idioms’ relatedness to lexicon makes the acquisition of idioms less associated with formal English as a foreign language (EFL) teaching, which tends to primarily focus on teaching grammar. The primary goal of this study was to evaluate the effects of informal learning on the acquisition of English idioms in view of everyday exposure to English through various media. The study was conducted on the students of preschool and teacher education studies (N=88; University of Zadar), and it incorporated a brief questionnaire regarding their habits when it comes to watching films, playing videogames, the use of social media etc., as well as a test containing 60 multiple–choice questions with examples of various English idioms. Hierarchical regression analysis revealed that the best predictor for the knowledge of English idioms is the frequency of listening to English and American music, while other significant predictors were the frequency of watching YouTube videos with foreign content, the frequency of playing videogames, the grades achieved in English language–teaching classes throughout high school and the scores on the English–language tests administered at the end of the first semester at the university; the total predictive value of the examined variables was surprisingly high (R2=0.612). Aside from discussing the implications of these results, the paper also reflects upon the fact that the frequency of watching English and American movies/TV shows turned out to be a negative predictor despite the positive correlation with the overall results on the test, as well as on the fact that the frequency of using social networks had no impact on the acquisition of English idioms whatsoever
Real ou Fake: desenvolvimento e aplicação de um jogo de cartas para o combate à desinformação no interior do Pará
Authors: Javorski Elaine , Gusmão Camila , Bargas Janine
Published: December 2023

Este artigo tem como objetivo refletir sobre o uso de materiais didáticos no combate à desinformação para o ensino básico como apoio a ações de educação e letramento midiático. A dinâmica parte de uma pesquisa-ação desenvolvida na Escola de Ensino Médio Dionísio Bentes de Carvalho, em Rondon do Pará/PA, na Amazônia Oriental, local considerado como deserto de notícias devido à escassez de informação jornalística local. A partir de uma pesquisa sobre o consumo de mídia por parte dos jovens do terceiro ano, foi produzido um jogo de cartas chamado Real ou Fake, posteriormente aplicado a esses estudantes. Os resultados evidenciam que o jogo pode ser uma oportunidade de se trabalhar em sala de aula conteúdos atuais e de interesse dos estudantes para que desenvolvam competência crítica em relação à mídia.
Editorial Vol. 42 N. 3
Authors: Holzbach Ariane , Tavares Camilla Quesada
Published: December 2023

Editorial Vol. 42 N. 1.
The Role of Environmental Principles in Mining Resources: A Discourse of Islamic and Indonesian National Law
Authors: Hidayah Ahdiyatul , Fahrozi Faturrahman , Rifani Ahmad
Published: December 2023

Human life is inherently intertwined with the environment, serving as the backdrop for all daily activities. It is within this environment that individuals fulfill basic needs such as sustenance, shelter, and resources, often without a full appreciation of the environment's profound significance. The extraction and utilization of resources, particularly from mines within the Earth, play a pivotal role in meeting human needs. This study highlighted that mine, as products derived from the Earth's depths, merit responsible stewardship to ensure sustainable use. It is imperative for humans to recognize the broader societal implications of mining activities beyond personal interests. Islamic principles advocate for the equitable distribution of mining resources as a communal right and shared property. This perspective allows for the enjoyment of these resources by all individuals. Islam does not preclude the delegation of mining resource management to the government, emphasizing national prosperity. In tandem with Islamic principles, Positive Law acknowledges the government's authority to grant mining rights to various entities. Private businesses, cooperative entities, and individuals are among those eligible for such rights, contingent upon obtaining proper business licenses from relevant authorities. This legal framework aligns with the overarching goal of fostering national development and ensuring responsible resource management for the benefit of society.
A Model Integrating Islamic Religiosity and Theory of Planned Behavior to Explain the Dynamics of Halal Consumption Behaviors
Authors: Abdul Khalek Aiedah , Hayaati Professor Dr. Sharifah , Ibrahim Hairunnisa Mohamad
Published: December 2023

Halal is a fundamental Islamic principle that generally shapes Muslim consumption behaviours. Even though the halal concept originates from religious sources, limited studies found focusing on the role of religiosity in investigating halal consumption behaviors. The Theory of Planned Behaviour (TPB) has been widely used to predict the behavioural intention of halal consumption behaviours among Muslims. This study aims to extend the discourse by integrating the religiosity construct in the TPB in which we examine the influence of religiosity as an additional variable to the other main determinants of behavioural intentions as theorized in the TPB. This is a cross-sectional study conducted among millennials Muslims who frequently eat out in the urban areas of Klang Valley, Malaysia. The findings reveal that religiosity has the strongest influence to determine halal food consumption compared to other determinants as outlined in the TPB. The proposed integration of religiosity variables in the TPB model contributes to extending literature in halal consumption as well as providing analysis on the role of religiosity in propelling the halal consumption behavior. Hence, this paper offers theoretical underpinnings and empirical evidence for this discourse.