bluuebunny/crossref_metadata_2025 huggingface dataset:
Negative Differential Resistance in Bidirectional Threshold Switching of Ag/HfOx/Pt Device
Authors: jiang zhiguo , Wang Dongliang , Li Yan , Zhang Yong , Chen Xinman
Published: February 2020

In this work, the dependence of negative differential resistance (NDR) on compliance current (Icc) was investigated based on Ag/HfOx/Pt resistive memory device. Tunable conversion from bidirectional threshold switching (TS) to memory switching (MS) were achieved through enhancing Icc. NDR can be observed in TS as Icc is below 800μA but vanishes in MS. The switching voltages and readout windows of TS evolve with Icc. Furthermore, the dynamic conductance (dI/dV) as a function of time in NDR can be well illustrated by capacitor-like relaxation equation, and the relaxation time constant is significantly dependent on Icc. These phenomena were elucidated from viewpoint of nanofilament evolution controlled by Icc as well as nanocapacitor effects originated from nanofilament gap. The Icc-dependent NDR as well as conversion between TS and MS on Ag/HfOx/Pt resistive memory device indicates its potential application as a multifunctional electronic device.
Memantine for prophylaxis of episodic migraine: a systematic review and meta-analysis
Authors: Mondia Mark Willy Llapitan , Espiritu Adrian , Bolaños Martha Lu , Artemio Jr. A.
Published: February 2020

Background Migraine is a common debilitating primary headache. Memantine is a non-competitive N-methyl D-aspartate (NMDA) antagonist that lowers neuronal excitability that could prevent migraine attacks.Objectives This study aimed to determine the efficacy and safety of memantine in patients experiencing episodic migraine attacks using a systematic review and meta-analysis.Methods We searched CENTRAL, MEDLINE, Scopus, Cochrane, LILACS, ClinicalTrials.gov, HERDIN and Google Scholar for relevant studies. Prespecified screening and eligibility criteria for inclusion were applied. Included studies underwent methodological quality assessment. Study design, patient characteristics, interventions given, and relevant outcomes were extracted and synthesized.Results This review included five relevant articles – 2 randomized controlled trials (RCT) and 3 observational studies (1 retrospective case-series, 2 prospective non-randomized open-label single arm trials). There were 109 patients included in the RCTs and 197 patients reported in the observational studies. Pooled data from the 2 RCTs showed that Memantine at 10mg/day decreased the monthly migraine days at 12 weeks compared to placebo with a mean difference of -1.58 [95% confidence interval (CI) -1.84, -1.32]. Observational studies also showed a decrease in migraine days per month with Memantine (5-20mg/day) after 12 weeks [95% CI]: -9.1 [-11, -7.23], -7.2 [-8.85, -5.55], and -4.9 [-6.29, -3.51]. There were no statistically significant adverse drug events (ADE) noted in patients treated with Memantine compared to placebo.Conclusion Memantine may be effective and well-tolerated as prophylaxis for episodic migraine.
Current Therapeutic Strategies and Perspectives for Neuroprotection in Parkinson’s Disease
Authors: Ghanta Mohan K. , Elango P. , L. V. K. S. Bhaskar
Published: February 2020

Parkinson’s disease is a progressive neurodegenerative disorder of dopaminergic striatal neurons in
basal ganglia. Treatment of Parkinson’s disease (PD) through dopamine replacement strategies may provide
improvement in early stages and this treatment response is related to dopaminergic neuronal mass which
decreases in advanced stages. This treatment failure was revealed by many studies and levodopa treatment
became ineffective or toxic in chronic stages of PD. Early diagnosis and neuroprotective agents may be a suitable
approach for the treatment of PD. The essentials required for early diagnosis are biomarkers. Characterising the
striatal neurons, understanding the status of dopaminergic pathways in different PD stages may reveal the effects
of the drugs used in the treatment. This review updates on characterisation of striatal neurons, electrophysiology
of dopaminergic pathways in PD, biomarkers of PD, approaches for success of neuroprotective agents in clinical
trials. The literature was collected from the articles in database of PubMed, MedLine and other available literature
resources.
Kluyveromyces marxianus as a Probiotic Yeast: A Mini-review
Authors: Homayouni-Rad Aziz , Azizi Aslan , Oroojzadeh Parvin , Pourjafar Hadi
Published: February 2020

Background:

Yeasts play diverse roles in human life. Since ancient times, these micro
organisms have been used to produce food products and beverages including bread and beer.
Nowadays, the biotechnological products of yeast are some of the main components of commercial
products.

Objective:

Some species of yeast such as Saccharomyces cerevisiae and Saccharomyces boulardii
are recognized as probiotic yeast with extensive applications in the food and drug industries. However,
certain species like Kluyveromyces marxianus are still not recognized as probiotic micro organisms
despite their widespread industrial usage. In this study, the application of K. marxianus in preparing
food and the medicinal product was reviewed in terms of its beneficial or harmful effects.

Methods:

Pub Med, Google Scholar, Scopus, and Science Direct databases were searched by using
“Probiotics”, “Yeast”, and “Kluyveromyces marxianus”.

Results:

The findings suggest that K. marxianus can be recognized as a probiotic yeast species.

Conclusion:

It can be concluded that K. marxianus may be considered as a probiotic micro organism
with a variety of commercial and medical applications.
Antioxidant Properties of Avicennia marina Leaf Extract in Soybean Oil System
Authors: Molaee Mohammad , Sahari Mohammad A. , Kenari Reza E. , Amirkaveei Shiva , Arbidar Elahe
Published: February 2020

Background:

Despite the widespread use of antioxidants during the storage of oils,
oxidation of fats and fatty foods is still reported to be the main reason for their quality drop. Synthetic
antioxidants such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) completely
escape and easily decompose at high temperatures. There are serious problems in relation to
the toxicity of BHA, BHT and tertiary butylhydroquinone (TBHQ), possibly due to their metabolism
and accumulation in organs and tissues. So finding a useful natural antioxidant is of great
importance, and due to the considerable presence of mangrove plant on the Southern Coasts of Iran,
this study aims to investigate the antioxidant properties of Avicennia marina leaves.

Objective:

Evaluation of the antioxidant activity of the Avicennia marina leaf extract and its
comparison with synthetic antioxidant TBHQ.

Methods:

By adding the ethanolic extracts of Avicennia marina leaves at different concentrations (2,
4 and 6 mg/mL) into soybean oil system at room temperature during 20 days and at different
intervals, their peroxide (PV), thiobarbituric acid (TBA), conjugated dienes (CD) and conjugated
trienes (CT), as well as fatty acid profile were measured. Antioxidant activity of the samples was
compared with that of TBHQ sample. Data analysis was performed using SAS, and a comparison of
average data was carried out using least significant difference (LSD) at a level of 0.01.

Results:

The antioxidant activity of 2 and 4 mg/mL concentrations of Avicennia marina leaf extract
in soybean oil was comparable with that of 0.2 mg/mL concentration of synthetic TBHQ. As a result,
this natural antioxidant can be used for the preservation of soybean oil.

Conclusion:

Due to the presence of phenols in the leaves, Avicennia marina leaf extract can be used
as a rich source of natural antioxidants.
Novel Selective Histone Deacetylase 6 (HDAC6) Inhibitors: A Patent Review (2016-2019)
Authors: He Xingrui , Li Zhen , Zhuo Xiao-Tao , Hui Zi , Xie Tian , Ye Xiang-Yang
Published: February 2020

Background:

Many human diseases are associated with dysregulation of HDACs. HDAC6
exhibits deacetylase activity not only to histone protein but also to non-histone proteins such as α-
tubulin, HSP90, cortactin, and peroxiredoxin. These unique functions of HDAC6 have gained significant
attention in the medicinal chemistry community in recent years. Thus a great deal of effort has
devoted to developing selective HDAC6 inhibitors for therapy with the hope to minimize the side effects
caused by pan-HDAC inhibition.

Objective:

The review intends to analyze the structural feature of the scaffolds, to provide useful information
for those who are interested in this field, as well as to spark the future design of the new
inhibitors.

Methods:

The primary tool used for patent searching is SciFinder. All patents are retrieved from the
following websites: the World Intellectual Property Organization (WIPO®), the United States Patent
Trademark Office (USPTO®), Espacenet®, and Google Patents. The years of patents covered in this
review are between 2016 and 2019.

Results:

Thirty-six patents from seventeen companies/academic institutes were classified into three
categories based on the structure of ZBG: hydroxamic acid, 1,3,4-oxadiazole, and 1,2,4-oxadiazole.
ZBG connects to the cap group through a linker. The cap group can tolerate different functional groups,
including amide, urea, sulfonamide, sulfamide, etc. The cap group appears to modulate the selectivity
of HDAC6 over other HDAC subtypes.

Conclusion:

Selectively targeting HDAC6 over other subtypes represents two fold advantages: it
maximizes the pharmacological effects and minimizes the side effects seen in pan-HDAC inhibitors.
Many small molecule selective HDAC6 inhibitors have advanced to clinical studies in recent years. We
anticipate the approval of selective HDAC6 inhibitors as therapeutic agents in the near future.
Improving Oral Surgery: A Workflow Proposal to Create Custom 3D Templates for Surgical Procedures
Authors: Peditto Matteo , Nucera Riccardo , Rubino Erasmo , Marcianò Antonia , Bitto Marco , Catania Antonio , Oteri Giacomo
Published: February 2020

Background:

Computer-guided technologies are adopted in various fields of surgery to limit invasiveness and obtain patient benefits in terms of surgery duration and post-operative course. Surgical templates realized through CAD/CAM technologies are widely diffused in implant dentistry. The aim of this work is to propose, beyond implantology, the feasibility of application of 3D printed surgical templates in oral surgery procedures requiring osteotomies (like maxillary cyst enucleation and tooth disimpaction) in order to obtain accurate surgeries, avoid anatomical damage of surrounding structures and decrease patient’s morbidity, using a simple, low-cost protocol of fabrication.

Objective:

To provide a reliable CAD-CAM workflow for the realization of surgical templates in oral surgery.

Methods:

Three clinical scenarios are described: A maxillary canine disimpaction, a mandibular cyst removal, and an orthodontic miniscrew placement. Each one was managed using custom surgical templates realized using the proposed workflow. A Stereolithography (STL) file of maxillary structures was obtained by the use of a 3D medical image processing software (Materialise Mimics 20.0) a segmentation toolbox acquiring RX volumes by Cone-Beam Computed Tomography (CBCT). Digital models of the teeth, acquired as STL files directly, are imported in the same 3D medical image processing freeware (Materialise Mimics 20.0) to merge STL files of maxillary structures and teeth. Data are transported into Blue Sky Plan 4.0 (Blue Sky Bio, LLC), a software for 3D implant guides fabrication, together with the DICOM images package of maxillary volumes to carry out the pre-surgical treatment planning. Anatomical structures at risk are identified; a contour of ideal incision shape and bone osteotomy extent is drawn. Finally, the resulting three-dimensional guide is digitally generated and the surgical guide printed. The resulting 3D template shows the following major features: teeth support, flap management and bone osteotomy design.

Results:

The proposed work-flow aided the surgeon in both pre-operative and intra-operative work phases through accurate virtual planning and the fabrication of precise surgical guides to be used in oral surgery practice. In each clinical scenario, the use of custom 3D templates allowed better control of the osteotomy planes and flap management. No adverse events occurred during both surgical and healing phases.

Conclusion:

The proposed digital workflow represents a reliable and straightforward way to produce a surgical guide for oral surgery procedures. These templates represent a versatile tool in maxillary cyst enucleations, tooth disimpaction, and other surgical procedures, increasing accuracy, minimizing surgical complications, and decreasing patient’s morbidity.
Biochemical and Pharmaceutic Properties of Genus Phyllanthus spp.: Focus on P. amarus Schum. & Thonn. and P. niruri L.
Authors: Souza Silva Maria Francilene , de Cássia E. de Oliveira Fátima , dos Santos Luciano Maria Claudia , Zocolo Guilherme J. , Pessoa Claudia
Published: February 2020

The genus Phyllanthus belongs to the family Phyllanthaceae with large global distribution,
with about 833 species, including Phyllanthus amarus and P. niruri. These species
are widely used in traditional medicine because of their pharmacological potential. The objective
of this work is to measure the potential of genus Phyllanthus after a technological and
scientific monitoring to quantify and evaluate publications and patents related to Phyllanthus
spp. with emphasis on P. amarus and P. niruri. The scientific monitoring summarizes morphotaxonomic,
pharmacological, chemical, ethnomedicinal and biological aspects. The research
was carried out based on papers found in journals deposited in the Web of Science
and NCBI (PUBMED) databases and on patents found in the European Patent Office
(ESPACENET), Google Patents and the National Institute of Industrial Property (INPI). The
results show strong interest in the areas of Pharmacology and Medicinal Chemistry. Patents
fall within the Human Necessities section by International Patent Classification as preparations
for Medical, Dental or Hygienic Purposes. The summary of monitoring analysis demonstrates
the potential pharmacological potential of P. amarus and P. niruri as agents to treat different
types of diseases and a range of possibilities for clinical trials in several areas of health.
STUDI TENTANG PELAKSANAAN HAK INISIATIF DPRD KUTAI KARTANEGARA PERIODE 2014-2018
Authors: Novianto Efri , Salehuddin Salehuddin
Published: February 2020

As an element of local government organizers, the DPRD is demanded to play an active role in carrying out its functions. One of the important functions of the DPRD is the formation of regional regulations together with the Regional Head. For the implementation of this function, the DPRD was given the right of initiative to submit a draft Regional Regulation. From the results of the study, the implementation of the DPRD Kutai Kartanegara initiative rights for the period 2014-2018 has been implemented well, but it is not optimal because on average only 14.63% has been passed into a Regional Regulation. In theory, the factors that influence the implementation of the DPRD initiative rights are education, experience and data / information factors, but this has been overcome by the existence of an Expert Team / Expert Group, workshops or training to increase the capacity of the DPRD and the Academic Script in each Design Regional Regulation submitted to the DPRD, so that it is no longer a limiting factor. The obstacles to the implementation of the DPRD's role are more due to political factors, budget support and consistency of regulations.
MENGUKUR KINERJA DESENTRALISASI ADMINISTRASI DI KOTA KUPANG
Authors: Pradana I Putu Yoga Bumi
Published: February 2020

This article aims to analyze the performance of the local government of the City of Kupang in carrying out administrative decentralization from the perspective of public service quality and community satisfaction surveys in the city of Kupang. This study uses descriptive qualitative methods and data collection was carried out through observation, surveys, interviews, and findings from literature studies, as well as secondary data studies. Informants from this study include, employees of the Population and Civil Registry Office, the Investment and One-Stop Integrated Services Office, and the Kupang City Lerik SK Hospital. In addition, there were 120 respondents to measure SKM in the field of cleanliness and clean water services in six districts of Kupang City which were determined using accidental sample techniques. The results showed the fact that the value of service quality in the area of population and health is still categorized as C or not good while in the one-stop integrated service sector it has a value of B or good. While the results of the community satisfaction survey show that only the health and integrated one-door services are categorized as good while the population, cleaning and water services are categorized as poor.
Science on tap: effective public engagement or preaching to the choir?
Authors: Ocobock Cara , Hawley Patricia
Published: February 2020

The goal of Science Cafés and Science on Taps is to encourage open discourse between scientists and the public in a casual setting (e.g., a bar) in order to improve the public understanding of, and trust in, science. These events have existed for over two decades, but there is no research studying their efficacy. Data presented here demonstrate that a yearlong Science on Tap series induced little change among the attendees with respect to attitudes, emotions, and knowledge about the nature of science. Ultimately, we found this event may be preaching to the choir rather than changing hearts and minds.
EXISTE DIFERENÇA SALARIAL EM FUNÇÃO DA ORIENTAÇÃO SEXUAL? ANÁLISE PARA O MERCADO DE TRABALHO CEARENSE
Authors: Oliveira João Paulo Cavalcante , Monteiro Vitor Borges , Irffi Guilherme
Published: February 2020

Para comparar as remunerações obtidas por indivíduos heterossexuais e homossexuais no mercado de trabalho em Fortaleza – Ceará, utiliza-se uma amostra por conveniência e, ainda adota o processo bola de neve, uma vez que os entrevistados homossexuais indicam seus irmãos heterossexuais. A escolha por irmãos se justifica para mitigar possíveis heterogeneidades de oportunidades e background familiar. Analisando os resultados, pode-se dizer que existe diferença educacional, sendo que os homossexuais possuem maior média educacional do que os heterossexuais; entretanto, não se observa diferença em termos salariais.
HABEAS CORPUS 143.641 E OS PROBLEMAS DO ENCARCERAMENTO FEMININO NO BRASIL
Authors: Torres Natalia Faccin Duarte , De Almeida Marco Antonio Delfino
Published: February 2020

O presente trabalho busca analisar quais foram os fundamentos jurídicos do Habeas Corpus Coletivo 143.641, concedido pelo STF, que abordou o caso Alyne Pimentel, considerada a primeira e única denúncia acolhida pelo Comitê para a Eliminação de Todas as Formas de Discriminação Contra a Mulher (CEDAW) e que responsabilizou o Brasil por uma morte materna evitável. Trata, ainda, dos problemas do encarceramento feminino no Brasil, demonstrando um pouco da realidade deplorável vivenciada por milhares de mulheres, e até mesmo por seus filhos, e a dificuldade que é a gravidez no cárcere, além de fazer uma análise da efetiva implementação do Habeas Corpus em questão
RETRATAÇÕES DE GÊNERO NOS JOGOS OLÍMPICOS RIO 2016
Authors: Garcia Rafael Marques , Silva Alan Camargo , Pereira Erik Giuseppe Barbosa
Published: February 2020

O objetivo deste estudo foi analisar as imagens exibidas nas principais agências internacionais de comunicação, mais precisamente como retrataram atletas homens e mulheres. Para tanto, utilizamos uma metodologia descritiva e qualitativa e a técnica de análise de imagens. Os resultados apontam tratamentos diferenciados para homens e mulheres na esfera internacional, consolidando as desigualdades nas representações de gênero pelas lentes da mídia esportiva intercontinental.
GÊNERO, HISTÓRIA E MEMÓRIA: EXPERIÊNCIAS COTIDIANAS DAS MORADORAS DE SERRA DO NAVIO E VILA AMAZONAS (1960 A 1985)
Authors: De Sousa Romulo Moraes , Lobato Sidney
Published: February 2020

Esse artigo discorre sobre experiências femininas ocorridas entre os anos de 1960 e 1985 nas company towns amapaenses Vila Amazonas e Serra do Navio, criadas pela empresa Indústria e Comércio de Minérios S.A. (Icomi). Objetivamos compreender estas experiências, situando-as nos espaços públicos e privados e tendo em conta os discursos normativos que permearam o cotidiano das trabalhadoras. As sociabilidades das mulheres e os discursos hegemônicos foram enfocados por meio de artigos da revista Icomi-Notícias e de entrevistas com antigos moradores e moradoras dos núcleos urbanos citados.
PARADIGMA FISIKA QUR’ANI DALAM TRIDHARMA PERGURUAN TINGGI KEAGAMAAN ISLAM
Authors: Susilayati Muslimah , Mufiq Mufiq , Syamsiyah Barid
Published: February 2020

This study aims to provide an overview on the application of the 'Qur'ani Physics' paradigm to the implementation of the Tridharma of Islamic Higher Education in Indonesia. Based on the qualitative-descriptive approach, the results of thisstudy suggest that the need for three stages to be carried out in the process of implementing the 'Qur'ani Physics' paradigm; First, the preparation phase, which begins with the equating of perceptions which the output is in the form of a decree on the integration team. Second, the planning phase, which consists of determining the main material, reviewing and revising the curriculum, as well as determining the strategic plan for research and community service. Third, the implementation phase, which consists of research and development, education and learning, as well as community service. With this integration model, the paradigm of the integration with its various philosophical variants is expected to become a solution for various social problems that occur in society. So that, organizing education at the Islamic Higher Education has a distinction with General Higher Education.
Didaktika biologie ve vztahu mezi obecnou a oborovou didaktikou
Authors: Chocholoušková Zdeňka , Hajerová Műllerová Lenka
Published: February 2020

Vysokoškolská učebnice didaktiky biologie, která má studenty učitelství vybavit profesními znalostmi a kompetencemi natolik, aby věděli „čemu a jak vyučovat“. Klade důraz na nezbytnost těsné spolupráce ve vertikálním směru, tj. mezi obecnou didaktikou a oborovými didaktikami, které pevně stojí na oborových základech.
Testing oil for wear products presence as diagnostic method of operational state of marine gearbox unit
Authors: Sergeev Konstantin Olegovich
Published: February 2020

The article discusses the results of determining the concentration of wear products in oil of marine diesel gearbox units on fishing vessels in order to use them for in-place diagnostics without dismantling. It was stated that the ultimate goal of diagnostics of wear products consists of identifying the increased wear rate, taking appropriate measures and predicting a possible accident. There has been brought the statistics for several years of monitoring different gearbox types: TKG2-0350 unit of Atlantic-335 type ships, SL2×3000 unit of Horizont type ships, gearbox of Atlantic-488 type ship, main gearbox of Kiev type ship, gearbox of Alpinist type ship. A formula for theoretical determination of the wear product concentration in lubricating oil is given, and a curve of the changing concentration of wear products has been illustrated. Conclusions are made about the information content and reliability of using the wear product concentration as a diagnostic parameter to determine the technical condition of the gearbox. The main reasons for the low information content of the method for determining the wear products in oil are provided. High metal concentrations in wear products in lubricating oil do not necessarily confirm the fact of accidental wear of gearbox parts. Instead of disassembling the gearbox, which leads to decreasing its resources, it is necessary to carry out diagnostics using various methods. It is recommended to analyze the wear degree of gearbox parts at least twice a year (after every six months of operation). There have been offered the reliable ways for improving the wear product diagnostic method.
Experience in creating laboratory of ship auxiliary mechanisms for training marine engineers in Astrakhan State Technical University
Authors: Pokusaev Mikhail Nikolaevich , Vinogradov Sergey Vladimirovich , Sibryaev Konstantin Olegovich , Gorbachev Maxim Michailovich
Published: February 2020

The article focuses on the functional capabilities, technical characteristics and bench composition of the laboratory of ship auxiliary mechanisms, which was created at the Department of Operation of Water Transport at the Astrakhan State Technical University (ASTU) for training marine engineers. The laboratory provides the students with professional competencies in such aspects of the mechanical engineer’s operation as ship turbo machines, ship auxiliary mechanisms and systems, automatic control systems, operation of ship boiler rooms and steam generating plants, etc. There have been presented the pictures of laboratory test benches for testing the P01 ship steering machine and ЯШ-2Р anchor mooring pin, РCC-6.3/10 ship fan, TKР-700 turbo compressor, gear fuel pump Ш5-25-3Б, prototypes of TГ-16M gas turbine generator and ГTД-16M gas turbine engine. Using the laboratory test benches for auxiliary mechanisms and systems helps to both consolidate the theory and gain the new practical knowledge on the design, operation principles and testing skills of the ship steering machine, deck equipment, ventilation systems gear pumps, turbochargers, etc. It has been stated that all the laboratory facilities, except for the GD-IN model (facilities for studying the pump operation and constructing pressure-flow characteristics), were developed and assembled by the students and teachers on the basis of the real ship equipment. The laboratory tests are based on regulatory and technical documents: the rules of the Russian Maritime Register of Shipping, machine operating instructions, relevant GOSTs, guidance and regulatory documents. Building the laboratory of auxiliary mechanisms and systems and optimizing the time for practical and laboratory training of ship mechanical engineers at ASTU were carried out in accordance with the requirements of the new educational standard GEF 3++ of higher education and the International Convention on Training and Certification of Sailors and Watchkeeping (The Manila amendments to the STCW Convention and Code).
Graphical analysis of free-surface wave fields from moving two consecutive posts connected by thin plate
Authors: Bimberekov Pavel
Published: February 2020

The article presents photographic materials of wave pictures from two consecutive posts of teardrop cross-section and the same posts with a thin plate installed between them, which introduces into consideration not only separate sequentially moving sources, but also reunites them into a single object, interacting along its entire length with the system of waves from the first source. The regularities of the wave field of consecutive posts with a plate in-stalled between them by means of graphic processing are considered. The possibility of finding the front imaginary source of the Kelvin wave pattern forming the ship's wave system at the position of both one and two wave-lengths in front of the top of the bow retaining wave is estimated. A method is proposed for determining the position of the fictitious location of the aft Kelvin wave system of the ship's wave system based on the results of the analysis of the wave field at the characteristic speeds

of movement, leading to the most successfully fixed inter-location of the wave pattern from the bow and aft extremities. There are shown the pictures of moving forward a pair of posts with

a blunt end of a horizontal section at the same speed and photo fixation from a close angle, pictures of moving forward the posts with a plate between them with a blunt end of a teardrop-shaped cross section at a low speed, moving forward posts with a plate at the side with a sharp end of a teardrop-shaped cross section, etc. All presented photographs were taken in the experimental pool of the Siberian state University of water transport (Novosibirsk state Academy of water transport) in 2006.
Organizing effective ship emergency squad subject to expenses on equipment and personnel training
Authors: Matonin Artemy Vladimirovich , Penkovskaya Kseniya Vyacheslavovna , Menshikov Vyacheslav Ivanovich
Published: February 2020

The paper focuses on the problem of the ship operation when it is necessary to provide survivability for the ship to overcome the effects of the external environment during the voyage, failures of technical equipment, and errors of the human factor. To maintain the ship’s survivability, the guidance documents recommend providing the emergency squad with the resource that is necessary to maintain the ship’s survivability in emergency situations. It is said that in the struggle for survivability of the ship each member of the emergency squad in real time should evaluate not only the technical and organizational equipment of the squad, but also the degree of readiness of the human factor, especially practical skills. The approach to the model of fighting for survivability of a ship associates functioning of the emergency squad first of all with the reliability of preventive measures of technical means and the effectiveness of professional training of emergency squad personnel. Within the framework of the policy of constant and comprehensive training of the emergency squad personnel, the ship and company authorities need to reduce using technical and organizational resources to a minimum level. The costs of training shipboard specialists from the emergency squad should also be minimized, but to the point where the specialist, obtaining the sufficient skills to fight for survivability justify the costs incurred
Analisis Kekerasan Seksual Pada Anak dan Intervensinya oleh Pekerjaan Sosial (Studi Kasus Kekerasan Seksual oleh Keluarga di Lampung)
Authors: Krisnani Hetty , Kessik Gisela
Published: February 2020

AbstrakKekerasan terhadap anak sampai saat ini marak terjadi. Kekerasan seksual pada anak merupakan salah satu tindakan kekerasan yang cukup mengalami peningkatan. Berdasarkan berbagai data, pelaku kekerasan berasal dari keluarga terdekat yang dimiliki korban. Kasus Kekerasan seksual yang akan dibahas pada saat ini yaitu berkaitan dengan tindakan kekerasan seksual Incest yang dilakukan oleh Ayah, kakak, dan adik yang dapat kepada korban yang merupakan anak berusia 18 tahun. Pada bagian ini akan dibahas mengenai analisis motif, dampak, sampai pada intervensi yang dapat dilakukan oleh profesi pekerjaan sosial pada anak dan keluarga. AbstractViolence against children until now is rampant. Sexual violence on children is one of the acts of violence which is quite increasing. Based on various data, the perpetrators of violence came from the closest family owned by the victim. Cases of sexual violence that will be discussed at this time are related to acts of sexual violence incest committed by fathers and siblings who get to victims who are children aged 18 years. This section will discuss the analysis of motives, impacts, and the interventions that can be carried out by the profession of social work in children and families.
IMPLEMENTASI PROGRAM CORPORATE SOCIAL RESPONSIBILITY OLEH PERUSAHAAN UNICORN DI INDONESIA
Authors: Yusuf Yoga Maulana , Prastyo Dimas Aji , Khaerunnisa Levina , Raharjo Santoso Tri
Published: February 2020

ABSTRAK Corporate Social Responsibility (CSR) adalah kegiatan perusahaan dalam mengelola bisnis perusahaan demi menghasilkan dampak positif bagi lingkungan masyarakat baik dalam bidang ekonomi, budaya, dan lingkungan. Hal ini karena perusahaan memiliki tanggung jawab terhadap efek yang dihasilkan oleh perusahaan. Seperti yang kita tahu, bahwa di Indonesia sendiri memiliki beberapa perusahaan besar yang dikategorikan sebagai Unicorn. Mayoritas dari perusahaan ini memanfaatkan teknologi komunikasi dalam prosesnya. Sehingga dampak yang dihasilkan jika dibandingkan dengan perusahaan yang memanfaatkan sumber daya alam, adalah sangat sedikit. Namun, keuntungan yang dihasilkan tidak kalah besar dibandingkan dengan perusahaan yang memanfaatkan sumber daya alam. Dilansir dari CNN Indonesia, bahwa keuntungan yang dihasilkan oleh salah satu perusahaan unicorn di Indonesia adalah sebesar Rp. 90,4 triliun per tahun. Namun apa saja kah implementasi CSR yang telah dilaksanakan? Terdapat tiga unicorn yang akan digunakan dalam penelitian ini yakni Tokopedia, Go-Jek, dan Bukalapak. Beberapa program yang akan dijelaskan yakni Nakamate oleh Tokopedia, Go-Scholar Tech oleh Go-Jek, BSC (Bukalapak Social Club) oleh Bukalapak. Penelitian ini dilaksanakan menggunakan pendekatan kualitatif dengan metode deskriptif sehingga peneliti ingin memberikan gambaran mengenai implementasi CSR pada perusahaan unicorn di Indonesia.  ABSTRACT Corporate Social Responsibility is company bussiness managing activity in order gaining positive impact for the environment and also in society who live around the company in economic, culture, and environment side. The company has the responsibility to the effect that might affect the society around caused by the company itself. Indonesia h as so many huge companies called unicorn cause mostly those companies use communication technology in the process of work. So that, compared to the others company who only use the natural resources in the work process has a big differ impact among it. But the profit is just almost the same huge. Reported by CNN Indonesia, the profit generated by one of the unicorn company in Indonesia is IDR 90.4 T per year. There are three unicorn companies that will be discussed in this research, namely Tokopedia, Gojek, and Bukalapak. Some programs that will be discussed are Nakamate by Tokopedia, Go - Scholar Tech by Gojek, BSC (Bukaalapak Social Club) by Bukalapak. This research uses qualitative approach with description method so that this research will give the descript ion about the implementation of CSR programs in Indonesian Unicorn Companies.
Os Cursos Técnicos Integrados do Instituto Federal de Mato Grosso do Sul | The Technical Courses Integrated from Federal Institute of Mato Grosso do Sul (Brazil)
Authors: Brizuena Tânia Mara Dias Gonçalves , Figueira Kátia Cristina Nascimento
Published: February 2020

Este artigo tem como objetivo analisar a constituição dos Cursos Técnicos Integrados de Nível Médio no Instituto Federal de Mato Grosso do Sul, Campus Campo Grande, no período de 2011 a 2015. Trata-se de estudo qualitativo, que tem como metodologia a análise documental, o uso de questionários e a entrevista semiestruturada. A pesquisa é norteada pela relação entre trabalho e educação, por meio das categorias de análise propostas por Petitat (espaço, tempo e conteúdos). Os sujeitos da pesquisa foram 20 estudantes egressos, 19 docentes e 1 diretor, os quais participaram dos 3 cursos (Informática, Eletrotécnica e Mecânica). Constatou-se que, apesar da existência da proposta de integração, a dualidade histórica não foi totalmente superada, pois, segundo os egressos dos cursos, nem sempre ocorre integração entre as unidades curriculares; além disso, na percepção da maioria, a referida integração ocorre apenas de forma parcial. Somente um quarto dos sujeitos afirmou perceber a integração, de acordo com a constatação de que 57,8% dos docentes compreendem a concepção de integração do Ensino Médio com a Educação Profissional com vistas ao desenvolvimento integral dos estudantes. Com isso, sinaliza-se que há aspectos a serem aprimorados pela comunidade acadêmica.
Zespół Imerslund-Gräsbecka - rzadka choroba genetyczna różnych ras psów
Authors: ŚLASKA BRYGIDA , TKACZYK ANGELIKA , KOWAL KRZYSZTOF
Published: February 2020

Zespół Imerslund-Gräsbecka (Imerslund-Grasbeck syndrome, IGS, zaburzenie wchłaniania jelitowego kobalaminy) jest rzadką autosomalną chorobą recesywą występującą u psów oraz ludzi. Przyczyną IGS są mutacje genów CUBM lub AMN, które kodują białka będące podjednostkami kompleksu receptorowego kubilina–amnionlessyna, odpowiedzialnego za wchłanianie kobalaminy (wit. B12) w jelicie cienkim. Najczęściej przyczyną choroby jest mutacja c.786delC lub c.8392delC w genie CUBM, w wyniku której dochodzi do przesunięcia ramki odczytu, powstania przedwczesnego kodonu STOP, a w konsekwencji degradacji mRNA. Zespół zidentyfikowano u różnych ras psów, m.in. border collie, owczarków australijskich i sznaucerów olbrzymich. Objawy kliniczne występują u młodych psów i obserwowane są ok. 8–12 tygodnia życia ze względu na wyczerpanie zapasów witaminy B12 w wątrobie. Pierwszymi objawami IGS są utrata apetytu oraz nieprawidłowy rozwój szczeniąt powiązany z niedokrwistością oraz białkomoczem.
Atrakcyjność podłoża w kuwecie dla kotów
Authors: Mataśka Iza , KRUPA WANDA
Published: February 2020

Problemem, z który boryka się wielu opiekunów kotów, jest nieprawidłowe korzystanie zwierząt z kuwety. Mikcja i defekacja poza kuwetą są jednymi z częściej podawanych zachowań przyczyniających się do oddawania kotów do schronisk. Podstawowymi cechami kuwety wymagającymi uwagi są: wielkość, konstrukcja, lokalizacja, dostępność, zapach, czystość i materiał, którym wypełniona jest kuweta. Rynek zoologiczny oferuje wiele rodzajów żwirku, jednak nie każdy wydaje się być odpowiedni. Celem pracy była próba oszacowania preferencji kotów względem dwóch rodzajów podłoża. Obserwacje przeprowadzono w schronisku dla zwierząt na dwóch grupach kotów (wykastrowane i niewykastrowane), podczas dwóch sesji dziennych i dwóch sesji nocnych. Rejestrowano liczbę mikcji i defekacji w kuwetach różniących się rodzajem zastosowanego podłoża. Średnia liczba mikcji i defekacji zrealizowanych w kuwetach o podłożu bentonitowym była większa niż w przypadku podłoża z drewnianego pelletu i dotyczyła obu grup kotów.
Porównanie metod resocjalizacji psów agresywnych
Authors: Rodak Gabriela Zuzanna , WIESZCZEK ANNA , SOKOŁOWSKI JACEK , GOLEMAN MAŁGORZATA
Published: February 2020

Celem pracy było porównanie skuteczności dwóch metod resocjalizacji psów: „zatapiania” i tzw. wzmacniania pozytywnego (połączenie desentytyzacji z przeciwwarunkowaniem). Badanie przeprowadzono w Schronisku dla Bezdomnych Zwierząt w Lublinie na grupie 8 samców po zabiegu gonadodektomii, które przebywały w schronisku od 6 miesięcy. Do badań wytypowano psy, u których zdiagnozowano zaburzenia behawioralne w postaci aktywnych zachowań agresywnych o podłożu lękowym. Psy podzielono na 2 grupy liczące po 4 osobniki (2 pewne siebie i 2 lękliwe). Za pomocą autorskiego testu zachowania zwierząt ze skalą punktową od 1 do 6, przeprowadzono trzykrotnie badania tj. na początku, w połowie i na zakończenie doświadczenia. Każda grupa psów resocjalizowana była inną metodą. Pod koniec doświadczenia za przydatne do adopcji uznano 6 psów, przy czym 4 z nich resocjalizowane metodą zatapiania dużo szybciej odnajdywały się w swoim środowisku i w krótszym czasie zaczęły ufać swojemu opiekunowi. Kontrwarunkowanie w grupie psów lękliwych odniosło znacznie słabsze efekty.
تحليل الأستثمار السياحي دراسة لاراء عينة من المديرين في المنظمات السياحية في إقليم كوردستان العراق
Authors: Oso Khairy A. , Abdal Nafser A.
Published: February 2020

هدفت الدراسة الحالية الى تحليل الاستثمار السياحي في اقليم كوردستان العراق ، وتمثلت مشكلة الدراسة بان قطاعات الاقتصاد الوطني في الاقليم تعاني من الضعف والاهمال كالزراعة والصناعة ، والنفط ما زال في البداية ، ورغم تمتع الاقليم بالعديد من المقومات الطبيعية والبشرية والمساعدة الى جانب وقوعه في موقع حضاري مهم ، الا انه مع ذلك لم تستغل تلك المقومات وبقي النشاط السياحي مهملا ، وان هذا الاهمال افقد الاقليم العديد من المنافع الاقتصادية والاجتماعية التي يمكن الحصول عليها من الاستثمار في القطاع السياحي ، وتمثلت اهمية الدراسة بدور القطاع السياحي في تحقيق التنمية الاقتصادية والاجتاعية للاقليم ، واعتمدت الدراسة المنهج الوصفي التحليلي ، واستخدمت استمارة استبانة للحصول على المعلومات ، وتم توزيع الاستبانة على مجموعة من مجموعة من المديرن في المنشات السياحية في محافظة دهوك واربيل والسليمانية ، بلغ عددها ( 250) استمارة ، وتم استرداد (206 ) استمارة صالحة للتحليل الاحصائي ، وبمعدل الاستجابة (82,4% ) .تمثلت اهم الاستنتاجات بقيام الحكومة بتوفير فرصة الاستثمار في القطاع السياحي وتدني مستوى الخدمات المقدمة الى السياح،وتوصلت الدراسة الى جملة من المقترحات تمثلت بضرورة استغلال الفرصة التي وفرتها الحكومة للمستثمرين لللاستثمار في القطاع السياحي،وتحسين مستوى الخدمات المقدمة الى السياح.
Migration Behavior of Immunoglobulin Y in Native Page Electrophoresis
Authors: Karimah Umul
Published: February 2020

ABSTRACT

Protein separation with electrophoresis in native state (native Polyacrylamide Gel Electrophoresis, native PAGE) is rarely applied in laboratory which results in limited scientific report. Native PAGE result can be used in further assay analysis or shows important protein-protein interaction. This study aimed to investigate immunoglobulin Y(IgY) behavior in separation using native PAGE. IgY protein is used since many properties of IgY are already known. IgY was isolated from follicles yolk and examined using clear native PAGE (CN-PAGE) and Sodium Dodecyl Sulphate (SDS) PAGE, both in reducing and nonreducing condition. CN-PAGE electropherogram of IgY showed streaked band from ~409-1048 kDa indicating IgY aggregation. Whereas SDS-PAGE in reducing condition showed normal result, ~68 kDa and ~18,7 kDa protein bands correlated with heavy and light chain of IgY respectively. Moreover SDS PAGE in nonreducing condition also resulted in normal IgY band sized ~185 kDa. Dilution and disaggregation using sodium dodecyl sulphate (SDS), sodium deoxycholate (SDC), sarcosyl, urea, and glycerol did not affect the migration behavior. We concluded that IgY is not in aggregate form. Migration behavior of IgY in CN-PAGE which was slow, produced streaked band, and appeared to have very high molecular weight is possibly due to low electronegativity (pI = 6,6±0,9) in CN-PAGE condition (buffer pH 8,3) and planar conformation of IgY.

Keywords: electrophoresis, immunoglobulin Y, native PAGE.
Karakterisasi Senyawa Bioaktif Antimikroba Ekstrak Umbi Bawang Tiwai (Eleutherine Bulbosa (MILL.) URB.)
Authors: Bone Mahfuzun , Rifai Yusnita , Alam Gemini
Published: February 2020

bulbosa adalah tanaman khas suku Kalimantan yang telah digunakan secara turun-temurun sebagai antibakteri. Penelitian ini bertujuan untuk menentukan karakterisasi senyawa aktif antimikroba E. bulbosa. Tahapan penelitian diawali dengan ekstraksi E.bulbosa dengan pelarut metanol dan partisi cair-cair menggunakan pelarut n-heksan, etil asetat, n-butanol. Uji Skrining antimikroba ekstrak methanol, n-heksan, etil asetat, dan n-butanol dengan konsentrasi 1 mg/mL. Ekstrak n-heksan difraksinasi dengan kromatografi cair vakum dan direfraksinasi kembali menggunakan sepacore. Fraksi aktif diisolasi dengan kromatografi lapis tipis preparatif dan diperoleh isolat aktif E. bulbosa. Hasil Identifikasi berdasarkan kromatogram menunjukkan isolat aktif E.bulbosa adalah golongan naphthalene. interpretasi data spektroskopi FTIR isolat aktif E.bulbosa menunjukkan adanya gugus OH hidroksil, CH alifatik, dan C=O. Hasil Interpretasi data 1H NMR isolat aktif E. bulbosa menunjukkan Data 1H NMR memperlihatkan adanya spektrum dari atom H-6 dengan nilai ? 6,92 ppm Mult. doblet dan J 10,5 Hz, spektrum dari atom H-8 dengan nilai ? 7,75 ppm, Mult. doblet dan J 10,5 Hz, spektrum dari atom H-9 dengan nilai ? 6,29 ppm, dan spektrum H-11 dengan nilai ? 3,21 ppm. Nilai Konsentrasi Hambat Minimum (KHM) isolat aktif E.bulbosa terhadap bakteri uji V. cholera, B. subtilis, S. mutans, S. aureus 0,0125% dan bakteri E. coli 0,025%. Disimpulkan bahwa isolat aktif E. bulbsoa adalah golongan senyawa naftalen dan memiliki aktivitas antimikroba.
Formulasi Krim Antibakteri Fraksi Etil Asetat Daun Kirinyuh (Chromolaena odorata)
Authors: Dewi Herlina Ekapratama , Ayu Welinda Dyah , Rusli Rolan
Published: February 2020

Ekstrak daun kirinyuh (Chromolaena odorata) mempunyai aktivitas antibakteri yang cukup baik terhadap beberapa bakteri patogen diantaranya bakteri S. aureus, E. aeruginosa dan E. coli. Penelitian yang dilakukan bertujuan untuk mengetahui bagaimana aktivitas fraksi etil asetat ekstrak etanol daun kirinyuh (Chromolaena odorata) terhadap beberapa bakteri patogen tersebut untuk kemudian diformulasi menjadi bentuk sediaan krim untuk mempermudah penggunaannya serta mengetahui pengaruh formulasi krim fraksi etil asetat ekstrak etanol daun kirinyuh terhadap sifat fisik dan aktivitas antibakteri terhadap bakteri S. aureus, E. aeruginosa dan E.coli. Krim memiliki konsentrasi fraksi etil 6%, 8% dan 10%. Krim dievaluasi  (organoleptis, viskositas, pH dan daya sebar) serta aktivitas antibakterinya terhadap bakteri S. aureus, E. aeruginosa dan E. coli. Hasil pengamatan sifat fisik krim menunjukkan dengan adanya kenaikan konsentrasi fraksi etil asetat akan menyebabkan peningkatan viskositas secara berturut-turut 3,26 Pa.s; 3,34 Pa.s dan 3,58Pa.s, penurunan pH secara berturut-trurut,56; 7,39 dan  7,27 serta  penurunan daya sebar krim secara berturut-turut 5,1cm; 4,7cm and 4,0cm. Uji organoleptis (bentuk, warna, bau dan homogenitas) menunjukkan adanya stabilitas pada sediaan krim. Krim memiliki warna hijau dengan kontras warna yang sesuai dengan konsentrasi fraksi etil yang digunakan, berbau khas daun kirinyuh dan memiliki homogenitas yang baik. Krim dengan fraksi etil asetat ekstrak etanol daun kirinyuh memberikan aktivitas daya hambat pada bakteri S.aureus secara berturut-turut 12,52mm; 13,90mm dan 12,42 mm. Pada bakteri E. aeruginosa memberikan aktivitas daya bunuh secara berturut-turut 13.21 mm; 13.70 mm dan 12.49 mm. Pada bakteri E.coli dengan daya bunuh berturut-turut adalah 13.46 mm; 13.30 mm dan 13,18 mm
Hepatitis C: Epidemiologi, Etiologi, dan Patogenitas
Authors: Alhawaris
Published: February 2020

Hepatitis merupakan penyakit peradangan pada organ hati yang disebabkan oleh berbagai faktor, salah satunya adalah infeksi virus. Virus Hepatitis C (VHC) merupakan salah satu virus dengan genom RNA yang dapat menyebabkan infeksi pada sel-sel hati (hepatosit) yang dapat menular melalui darah. VHC memiliki berbagai genotipe yang tersebar di berbagai belahan bumi yang telah teridentifikasi dan terklasifikasi. VHC tersusun atas berbagai protein yang merupakan hasil ekspresi RNA VHC. Protein tersebut terdiri atas protein struktural maupun non-struktural yang memiliki fungsi masing-masing, khususnya pada saat menginfeksi sel inang. Protein-protein VHC tersebut dapat menginisiasi sistem pertahanan tubuh sehingga timbul respon imum tubuh terhadap VHC. Genom VHC dapat mengalami mutasi sehingga mempu menghindari respon imun inangnya. Kegagalan respon imun tubuh untuk mengeliminasi VHC menyebabkan kerusakan pada sel-sel hati hingga berpotensi mengalami sirosis bahkan kanker. Ko-ifeksi VHC dengan infeksi mikroorganisme lainnya atau bahan-bahan lainnya yang dapat menurunkan fungsi normal organ hati dapat memperparah perjalanan penyakit hati. Variasi genetik dan kecepatan VHC untuk bermutasi menyebabkan sulitnya memperoleh vaksin yang tepat untuk virus tersebut, sehingga berpotensi menjadi penyakit yang bersifat silent epidemic.
Pengaruh Media Booklet dan Reminder Terhadap Kualitas Hidup Pasien Kanker Serviks dengan Kuesioner EQ-5D
Authors: Putu  , Welinda  , Adam  , Angga
Published: February 2020

ABSTRAK

Pendahuluan : Kanker serviks menempati posisi kedua di Dunia yang dapat menyebabkan kematian sebesar 80% pada Negara berkembang. Tujuan dari penelitian ini untuk melihat pengaruh pemberian booklet dan reminder pada penderita kanker serviks. Metode : Desain penelitian ini menggunakan One Group Pre Test and Post Test. Teknik pengambilan sampel menggunakan purposive sampling. Analisis data menggunakan uji statistik parametrik (paired t-test). Hasil : Pada kelompok booklet diperoleh EQ5D indeks dengan nilai sig p­= 0,433 sedangkan VAS method dengan nilai sig p= 0,079 dan pada kelompok reminder diperoleh EQ5D indeks dengan nilai sig p= 0,027 sedangkan VAS method dengan nilai sig p= 0,013. Kesimpulan : Tidak ada perbedaan yang signifikan pada kelompok booklet dan terdapat perbedaan yang signifikan pada kelompok reminder.

Kata Kunci : Kualitas hidup, Kanker serviks, Booklet, Reminder