bluuebunny/crossref_metadata_2025 huggingface dataset:
Moçambique : o caso dos jor ões dos direitos humanos
Authors: Luca Bussotti
Published: July 2023

The article aims at understanding how the Mozambican press covers the violations of human rights by the State, inside and outside prisons, focussing on the biennium 2008-2009, considering the two most common newspapers of the country, Notícias (public) and O País (independent). These two newspapers haven´t got an editorial line on human rights yet: the first one (Notícias) intends to defend the name of local institutions, considering violations as isolated individual initiatives (generally by policemen); the second one (O País) represents the Police as the worst violator of human rights in Mozambique. Hence the different approach: Notícias privileges institutional sources, while O País the “alternative” ones, using reportages, verifying the facts and, if necessary, contesting the version of authorities.
As questões dos Direitos Humanos na im-prensa escrita cabo-verdiana entre 2008 e 2009 : os casos dos jornais A Semana e Expresso das Ilhas
Authors: Redy Wilson Lima
Published: July 2023

This article examines the coverage of the issue of human rights in two private weeklies in Cape Verde, “A Semana” and “Expresso das Ilhas” between the years 2008 and 2009. Content analysis, linking quantitative and qualitative data, focusing particularly on the activities of youth gangs, through editorials shows that the press actually attracts the readers’ attention on issues of human rights violations, but they are still covered superficially.
13 - Ali A. Mazrui: A Great Man, a Great Scholar
Authors: Seifudein Adem
Published: July 2023

Abstract
7 - Cybersecurity in Africa: Understanding the Implications of the New Cyber-environment
Authors: Magu Stephen M.
Published: July 2023

Abstract
32 - Plants will miss your Shade / Huge Loss
Authors: Shivji Issa , Mazwi Freedom
Published: July 2023

Abstract
Perlindungan Rahasia Dosa Peniten dalam Sakramen Tobat
Authors: Suwito Benny
Published: July 2023

Catholic Church will always maintain the secret of the confession because confession is sacred and a priest has no right to reveal the contents of the confession to anyone. In order to understand properly why a priest cannot reveal the sins of the penitent or must protect the content of the confession, the writer is intended to review it through the lens of Canon Law and start by looking back at the meaning of Sacrament of Penance as the Church’s foundation to provide guarantees to penitents, even if they have serious sins such as sexual abuse. The writer expects that this article will open up an understanding that the confession of sins gets the right place so that the readers understand why priests must always keep the secret even if they would be punished for doing so.
Structural response of precast concrete segmental tunnel linings
Authors:   , Arnau Delgado Oriol
Published: July 2023

The increasing use of the tunnel boring machines (TBMs) has entailed their own evolution and the improvement of the construction processes applied, allowing the construction of tunnels on more complex hydro-geological conditions. These new drilling facilities imply that higher ground and water pressures have to be resisted by the structural lining, turning its design into a key item in all current tunnel projects.
TBMs construction process is mainly associated to precast concrete segmental tunnel linings, which are consisted of concrete rings sequentially placed as the tunnel drilling advances. Despite segmental tunnel linings are widely used, their structural response presents significant uncertainties due to the particular configuration on multiple precast pieces and the evolutionary construction process applied. The improvement and optimization of segmental tunnel linings, necessary to obtain safer structures at a lower cost, requires a significant advance in the knowledge of their structural response and about the appropriate techniques to properly reproduce it.
This PhD thesis present the mechanisms and phenomena involved in the structural response of precast concrete segmental tunnel linings, detailing numerical modeling strategies to properly simulate them. The integration of all these techniques in a unique model allows the analysis of a real tunnel lining subjected to different scenarios, determining the influence and relevance of the main parameters defining a tunnel and its structural lining.
Present research departs from an innovative in situ test carried out at Line 9 subway tunnel in Barcelona. The treatment and analysis of the obtained data provides experimental evidences about the structural response of segmental tunnel linings and the main involved mechanisms and phenomena. Different numerical simulation strategies are developed in order to properly reproduce such mechanism and phenomena, achieving a reliable simulation of an isolated ring response. The longitudinal response of the segmental concrete linings is obtained through the detailed study of the construction process applied and the ground-structure interaction mechanisms. The knowledge of the longitudinal force present at a segmental tunnel lining is of paramount importance in order to determine the interaction degree between adjacent rings and the consequent three-dimensionality of the lining response. Finally, the numerical simulation of a real tunnel section subjected to different scenarios of load and boundary conditions determines the influence of the three-dimensional effects on segmental concrete linings response, concluding about its structural implications in respect to the isolated ring approach usually employed in design processes.
Identifying Customers’ Barriers in Buying Sustainable Beauty Products
Authors: Peyton Fanny , Purwanegara Mustika Sufiati
Published: July 2023

Customers' deeper understanding of environmental issues plays a role in the swift growth of sustainable beauty enterprises. The desire of consumers to purchase sustainable beauty products have also increased, according to studies. Due to the pandemic, the sustainable beauty market is likely to rise in the next years as people strive for a healthier, more environmentally conscious lifestyle. Firms are also continually producing inventive products to satisfy the demands of their clients and to keep up with the rising competition. Researchers revealed how sustainable practices can increase brand loyalty and help firms succeed in more competitive surroundings. Other experts, on the other hand, have noted that even knowledgeable clients to environmental issues are not purchasing these sustainable products. Negative customer perceptions emerge, and it is unclear how their behavior will alter. This study uses qualitative method through thematic analysis in obtaining the data. The form of data is statements from online conversations from social media and beauty communities. This study discovered the barriers to buy from customers’ view, include the difficulty to search for suitable products for their skin, expensive price of product compared to its quality, low trust to brands, poor product quality, poor product hygiene, and bad production process management by firms. These barriers are also related to how they are more aware of green washing marketing methods. These insights would be beneficial for beauty firms who are willing to gain new target markets by emphasizing brand communication and practices that would decease customers’ concerns towards sustainable brands and lead them to product purchase. Firms could improve their product innovation to increase its performance, quality, and effectiveness to attract customers by also communicating their sustainable practices through their communication in the form of advertisements, value proposition, or product positioning.

Keywords:  sustainable beauty, product purchase, barriers to buy
Kebijakan Hukum Pidana Terhadap Perkembangan Tindak Pidana Kekerasan Seksual yang Bertujuan Menciptakan Keadilan Gender
Authors: Nur Khumaeroh Irda
Published: July 2023

Untuk melindungi dan memperjuangkan hak-hak perempuan dan anak-anak yang menjadi korban kekerasan seksual. Kebijakan ini bertujuan untuk menegakkan hukum dan memberikan sanksi yang tegas terhadap pelaku kekerasan seksual serta memberikan perlindungan dan dukungan bagi korban. Metode pendekatan yang digunakan yuridis sosiologis yaitu sebuah metode penelitian hukum yang digunakan dalam upaya melihat dan menganalisa suatu aturan hukum yang nyata dan ada di dalam masyarakat. Metode pengumpulan data dengan wawancara, penelitian kepustakaan, studi dokumen, dan menggunakan metode analisis data kualitatif. Kebijakan hukum pidana mengenai tindak pidana kekerasan seksual menurut KUHP didalamnya mengatur tentang perzinahan, perkosaan persetubuhan dengan perempuan di bawah umur, pencabulan. Problematiknya berada pada sistem hukum (substansi, struktur, dan budaya hukum) yang belum memihak pada keadilan bagi korban. Maka dapat disimpulkan bahwa Kebijakan hukum pidana mengenai tindak pidana kekerasan seksual menurut Kitab Undang-Undang Hukum Pidana (KUHP) termuat dalam Bab XIV tentang kejahatan terhadap kesusilaan yang didalamnya mengatur tentang perzinahan, perkosaan persetubuhan dengan perempuan di bawah umur, pencabulan
Projects’ success and respective factors that produce it – The case of Higher Education Institutions in Albania
Authors: OSMËNAJ Jola
Published: July 2023

Organizations and institutions are in continuous change. What remains unchanged is their need for new and continuous participation in international and national projects, as an incentive to adapt to innovations and to develop cooperation. In order to realize all the set objectives and fulfil initial goals, it goes without saying that a project should be based on a framework of criterions, considered as crucial for a successful implementation and realization of projects. The paper addresses such framework, criteria and the related issues with a special focus on HEIs in Albania. Through the review of a rich literature, we have worked on the definition of a project, the development phases, as well as some projects undertaken by HEIs. The methodology used consists in utilizing the semi-structured interviews, and the survey analysis will be done in the QDA Miner Lite program, thus drawing final conclusions, thereon. The study shows that, generally HEIs in Albania have taken solid steps towards developing sustainable and successful projects, being aware of the necessary criteria that drive success and the monitoring of projects during all project’s stages.
Tax Amnesty – The choice between fiscal discipline and economic development. The case of Albania
Authors: KAMANI Xhemalie , SHEHU Elona , MUCEKU Hysen
Published: July 2023

Nowadays, the various problems in the economy are directly affecting the economic development of the countries considering tax abuse as a serious issue in the economy, in overall. The conflict arising in nowadays society seems to be between the demand to increase welfare and consequently the refusal to face tax obligations. Hence, a country’s economy cannot upgrade itself without the efficiency of fiscal policies. The scope of this article is to analyze the relationship between fiscal discipline and economic development in Albania. The objectives of this research are to review the literature on tax amnesty program and describe the factors related to tax amnesty, such as: implementations, costs and benefits, participation and the effects of the program and lessons learned from countries around the world to show the connection that exists between tax amnesty and economic development in Albania. For all possible standards in the country, it is very important that the state budget is reimbursed in a timely manner. Undoubtedly, the question that arises on behalf of this paper is whether the tax amnesty would serve as an aid for the reimbursement of the state budget.
Quality of institutions, foreign direct investments and economic growth: empirical evidence from Balkan economies
Authors: TOPI Kevin , XHEPA Selami
Published: July 2023

This paper analyzes the relationship between institutions, foreign direct investment (FDI) and economic growth in the Western Balkans region. We use a difference-indifference method to evaluate the impact of institutions on attracting FDI and promoting economic growth and we find evidence, which support that quality of institutions is an important policy variable. The research shows that institutions play a key role in determining economic growth and attracting foreign investment. This highlights the importance of creating and maintaining inclusive institutions that promote the rule of law, control of corruption, and regulatory quality, which can lead to increased economic development and investment.
Financial literacy of students in Serbian language and literature classes in the second cycle of primary education
Authors: Čorboloković Saša , Nikić Biljana
Published: July 2023

Financial literacy is important not only for the independent development of an individual but also for the progress of the entire society; hence, the need to include financial literacy in the education system. This paper investigates several aspects of introducing financial literacy in Serbian language and literature classes in the second cycle of primary education. The paper showed that financial literacy does not have to be a separate subject; its principles can be adopted gradually and in the classes of core subjects. This study aims at investigating the areas and teaching units of the curriculum wherein the topics of money, consumption, saving, and value and its good and bad sides could be incorporated; it also looks at the practical implications of financial literacy in real-life situations. The analysis of the curriculum of the Serbian language and literature course, from the fifth to the eighth grade, has shown that the subject provides a good framework for developing financial literacy. This can be done mainly through two teaching and learning areas-literature and language use. This study investigates how money and its value can be discussed when interpreting many literary works. Existence and social status depend on money; money is often a means for achieving various goals and it helps build up literary characters. In the area of language use, lexical exercises can be enriched with examples from lexicology and phraseology that are thematically related to finance. In addition, thoughtful use of non-linear texts can be very useful for practicing data search. There are numerous topics for discussion or essays that contribute to the formation of good financial habits, especially in the age of consumerism and the constant appearance of new products with aggressive marketing. Finances can be discussed in all types of classes and through a wide range of tasks, e.g., quizzes that can also be devised in a digital format. In this way, numerous concepts of financial literacy are being adopted gradually, students are motivated to work, behave responsibly, and develop critical thinking skills; they are trained to understand the importance of thoughtful financial decisions better and easier and apply financial literacy principles later in adulthood.
SBPdePA entrevista Stefano Bolognini
Authors: Bolognini Stefano
Published: July 2023

Entrevista realizada em Porto Alegre, em junho de 2008, exclusivamente para Psicanálise – Revista da Sociedade Brasileira de Psicanálise de Porto Alegre, por ocasião de sua vinda para participar de atividades científicas. A entrevista foi concedida em inglês. Participaram da entrevista: Carmen Lúcia M. Moussalle, Carmen Saile Willrich e Rosa Beatriz Santoro Squeff como entrevistadoras e Daniel Ohlmweiler Ritzel como intérprete.
Fendas e fraturas no contato analítico
Authors: Fagundes José Otávio
Published: July 2023

O autor tece considerações sobre as fendas e fraturas no contato analítico, surgidas sobretudo a partir de dificuldades narcísicas na relação transferencial e contratransferencial, trazendo citações da literatura psicanalítica. Ilustra o tema com um caso clínico.
solidariedade em face da fragilização dos vínculos na era pós-moderna
Authors: França Maria Olympia
Published: July 2023

A Psicanálise surge no período da modernidade, entre o final do século XIX e o início do século XX, em decorrência da preocupação de um homem – Freud –, como de vários outros de sua época, com o bem e o mal-estar da civilização, e dirige-se, sobretudo, à qualidade da vida afetiva-emocional vigente. Nasce, assim, como um ato de solidariedade. A quê? Ao sofrimento humano do semelhante, pois, ao proporcionar o desenvolvimento emocional mediante o fortalecimento dos vínculos afetivos, ajuda o homem a aproveitar melhor seus recursos de sobrevivência. A Psicanálise ressalta a capacidade de se solidarizar como um dos elementos constitutivos da maturidade emocional. [...]
Novas construções em análise
Authors: Spessoto Leda Beolchi
Published: July 2023

Este trabalho faz uma analogia entre as construções em análise propostas por Freud em seu artigo de 1937 e as novas construções que se mostram necessárias no atendimento a pacientes com condições mentais de muita precariedade para desenvolver pensamento e vínculo entre eles e suas emoções.
O futuro da psicanálise como profissão
Authors: Francischelli Leonardo
Published: July 2023

Trabalho apresentado na IX Jornada da Sociedade Brasileira de Psicanálise de Porto Alegre. Porto Alegre 25 e 26 de Novembro de 2011.
Palavras da Presidente
Authors: Surreaux Helena Ardaiz
Published: July 2023

Este número de Psicanálise – Revista da Sociedade Brasileira de Psicanáli- se de Porto Alegre leva a marca de ser o primeiro desta gestão. [...]
Repercussão do uso do crack sobre o feto e sobre o vínculo mãe-bebê
Authors: Castro Jorge Salis de
Published: July 2023

A invenção do crack não é um drama, é uma tragédia para a humanidade. Enquanto a natureza trabalhou mais de três bilhões de anos para dar condições ambientais de vida para o neurônio humano e o seu desenvolvimento, o crack em apenas 18 segundos possui um potencial capaz de destruir toda essa conquista. [...]
ideal do ego e as paixões
Authors: Santos Marília Amaro da Silveira Modesto
Published: July 2023

Este trabalho tem por objetivo mostrar a ligação entre o narcisismo e o superego remontando à origem e aos diversos caminhos que o narcisismo pode tomar e o quanto esses caminhos são determinantes na formação de um superego cruel ou protetor. Partindo do trajeto que Freud seguiu para definir o conceito de superego e utilizando alguns autores pós freudianos, como por exemplo Chasseguet Smirguel, percorro um pouco a história do senhor B que foi vivenciada nas sessões de análise.
ética do afeto
Authors: Dias Maria Berenice
Published: July 2023

O presente artigo versa sobre a visão da sociedade e do Direito, em relação à união de casais do mesmo sexo, no decorrer da história da humanidade. Traz ainda os últimos alcances jurídicos conquistados no que diz respeito às novas configurações familiares em relação à união estável e adoções. Ressalta a importância de ser substituída a expressão homossexualidade por homoafetividade, uma vez que família designa qualquer relação íntima de afeto, pela lei.
Acerca del malestar en la formación psicoanalítica
Authors: Leivi Miguel
Published: July 2023

El trabajo aborda la cuestión de la transmisión del psicoanálisis y de la formación de los psicoanalistas; su relación con los distintos contextos de las instituciones psicoanalíticas; la historia de su organización y las diferentes configuraciones que se produjeron; los conflictos, cuestionamientos y malestares a los que da lugar, así como algunas reflexiones sobre el carácter estructural de ese malestar y algunas ideas acerca de cómo posicionarse ante el mismo y de cómo encarar la tarea formativa, atendiendo a las condiciones actuales de la práctica analítica.
Supervisão e análise pessoal
Authors: Gutfreind Celso
Published: July 2023

Neste artigo, com o mote da diferença, o autor propõe uma reflexão sobre o que afastaria e o que aproximaria – igualdade e diferença – a atividade de Supervisão Analítica da Análise Pessoal, ambas situadas no tripé da Formação Analítica. As conclusões, sempre provisórias, apontam para aproximações possíveis entre ambas no que se refere à defesa de uma posição analítica em prol da abertura de sentidos e, também, diferenças importantes no que se refere ao cuidado de não interpretar, à guisa de tratamento, movimentos transferenciais e contratransferenciais sempre presentes.
Reflexões sobre a teoria da angústia em Freud
Authors: Degani Rafaela
Published: July 2023

Este trabalho apresenta uma revisão teórica sobre a teoria da angústia ao longo da obra de Sigmund Freud. Desde o início de seus estudos, em suas publicações ditas pré-psicanalíticas, Freud já se ocupava com esse tema. Diante disso, o presente artigo propõe demonstrar a evolução e a continuidade do pensamento Freudiano acerca da teoria da angústia. Para tanto, parte dos textos iniciais sobre as neuroses atuais até o desenvolvimento da teoria da angústia de castração versus o trauma do nascimento em Inibições, sintomas e ansiedade, de 1926. Com vistas a uma melhor compreensão dessas questões, a autora utilizou dois exemplos clínicos, um remetendo à angústia do trauma do nascimento e o outro à angústia de castração.
Revisitando o complexo de Édipo
Authors: Meller Lores
Published: July 2023

Este texto é uma síntese de minha participação na atividade “Encontro com os Fundadores”. Na ocasião, participei da mesa “Revisitando o complexo de Édipo”, na qual estavam presentes Ana Rosa Trachtenberg, Gildo Katz e José Facundo. Centralizei minhas ideias a partir de uma articulação do complexo de Édipo (CE), de sua resolução com o momento institucional a que, após 26 anos de fundação, tanto a Sociedade como o Instituto estavam ao serem dirigidos por integrantes da segunda geração, pelos “filhos” da geração dos fundadores. [...]
sonhar e o brincar, simbolismo do mundo interno da criança
Authors: Santa María de Gómez-Roch Olga
Published: July 2023

Este trabalho apresenta como os sonhos, por natureza própria, despertam aspectos lúdicos. Seus simbolismos e significados não são inerentes, mas temos que atribuí-los ao sonhador, que, com ou sem ajuda de seu intérprete, se interessará pela sua elaboração, direcionada ao autoconhecimento. No contexto da análise infantil, propõe-se ir além da mera realização de desejos. Dá-se importância ao sonho como material de brincadeira dentro do contexto terapêutico, chegando a novas perspectivas organizacionais da economia libidinal, a novos esquemas representacionais e à facilitação do processo analítico, com a conquista do prazer.
Para compreender o anterior, são consideradas implicações lingüísticas e extralingüísticas. Explicam-se as imagens como matéria-prima para a elaboração no terreno extralingüístico, e a palavra, no lingüístico. Este processo de expressão simbólica dá-se de idêntica e paralela maneira, tanto no sonhar, quanto no brincar.
A imagem tem uma sobredeterminação, no sentido do ilimitado de seu simbolismo, de tal maneira que a criança que sonha poderá, com seu sonho, assim como com sua brincadeira, viver seu drama pessoal, refletindo, sem intencionalidade, sem temporalidade, nem seqüência organizada, o mais inconsciente de seu mundo interno. Concluímos com diferentes tipos de sonhos que as crianças têm, além de duas vinhetas que exemplificam sua utilidade analítica. O sonho, como a brincadeira, é construído em um espaço de uma única pessoa, e, portanto, o domínio está naquele que brinca e naquele que sonha no que se refere às primeiras tentativas de associações auto-interpretativas.
Palavras do editor
Authors: Fetter Heloisa Helena Poester
Published: July 2023

A equipe editorial da Revista da SBPdePA está fechando mais uma etapa de intenso e gratificante trabalho. Na verdade, é um ciclo que se completa – resultado da união de colegas voltados a um objetivo comum –, mas também que contribui para a estruturação de uma tradição científica, na medida em que a Revista congrega e exterioriza o pensamento da Sociedade como um todo. Dessa forma, não podemos deixar de reconhecer o trabalho das equipes anteriores (o passado como reservatório que nutre a nossa fome de saber) e dizer da nossa expectativa com o que poderá ser realizado pela nova equipe (o futuro com suas infinitas aberturas). [...]
Trauma e literatura
Authors: Leal Carlos F. L. Pires
Published: July 2023

O trabalho propõe a reflexão sobre a articulação entre literatura e trauma, este último considerado à luz da teoria psicanalítica. Recorrendo à obra de escritores como Proust, Borges e Celan, situa a repetição não somente como falha da representação, mas como origem da elaboração estética das obras literárias.
Algumas considerações sobre o conceito de analisabilidade na atualidade
Authors: Rodrigues Ane Marlise Port
Published: July 2023

A partir de uma revisão da literatura e de algumas respostas de um questionário sobre analisabilidade, aplicado à totalidade dos componentes da SBPdePA, no período de novembro/2006 a janeiro/2007, a autora encontra que o conceito de analisabilidade é um conceito em constante evolução que leva a novas aberturas: desloca-se o eixo principal do diagnóstico do paciente para as possibilidades do par analítico; amplia-se a noção de transferência em relação ao analista para a transferência sobre o enquadre analítico, principalmente em patologias com déficits narcísicos; introduz-se a questão do ensino da psicoterapia psicanalítica na formação analítica, a partir da demanda clínica atual, entre outras questões.
Pesticide Residue Contamination of Some Cereals and their Consequential Health Implication in the Food Chain of Taraba Northern Geo-political Region, Taraba State
Authors: Barau B. W. , Yusufu W. N. , Abubakar A. , Fadilah A. S.
Published: July 2023

Aim: To investigate the Pesticide Residues (PRs) contamination of some cereals and determine their health risks in the food chain of Taraba North Geo-political region.

Study Design: Maize, Millet, Rice and Sorghum, and their soils were randomly collected from farmers’ field in three (3) LGAs of Taraba North.

Place and Duration of Study: The samples were collected from Ardo-kola, Karim-lamido and Zing LGAs of Taraba State. They are processed at Laboratories of Biological Sciences Department of Taraba State University and Analyzed at the Department of Chemistry, Yobe State University, Damaturu, Yobe State, between September, 2021 – March, 2022.

Methodology: Soils and ripe cereals stalks were collected applying the principles of randomization. These samples were processed, pulverized into powdered form, and analyzed for pesticide residues (PR) using the Gas Chromatograph - Mass Spectrometer (GC-MS).

Results: Ten (10) pesticide residues in different concentrations were recorded, with some of them occurring above the permissible limits. Isopropylamine accounted for 21% of total contaminants' concentrations, followed by carbofuran (14%), dichlorvos (12%), t-nonachlor (11%), heptachlor (10%), HCB and g-chlordane all at 9%, DDT (7%), Endosulfan (6%), and Aldrin at 1%. Health implications showed that some of the cereals are unsafe for consumption. In Ardo-Kola and Zing, only millet had a Hazard Index (HI) of less than 1, while in Karim-Lamido, millet and sorghum recorded HI ≤ 1. In Ardo-Kola trend in HI values in adullts was rice (53.32) ˃ sorghum (24.35), ˃ maize (10.99), ˃ millet (0.82), while in children, the trend was rice (64.50), ˃ sorghum (24.71), ˃ maize (10.65), ˃ millet (0.90). In Karim-Lamido, HI values in adults were in the following order: rice (54.64) ˃ maize (38.44), ˃ millet (0.62), ˃ sorghum (0.35). At the same time, HI in children followed the order; rice (66.10) ˃ maize (46.50), ˃ sorghum (0.74), ˃ millet (0.73). In Zing, HI values were in descending order of rice (32.20) ˃ sorghum (12.27) ˃ maize (8.27) ˃ millet (0.47), in adults, and rice (38.97) ˃ sorghum (14.86) ˃ maize (9.99) ˃ millet (0.55), in children. Overall, children are at a higher risk of toxicity than adults.

Conclusion: It was deduced at the end of the study that pesticides residue are bioaccumulating in the food chain due to excessive use in many agricultural phases. Hence we recommended intensified efforts in check-mating these products in our agricultural systems.
Pogo transposons provide tools to restrict cancer growth
Authors: Zueva Elina , Burbage Marianne
Published: January 2025

Transposable elements provide material for novel gene formation. In particular, DNA transposons have contributed several essential genes involved in various physiological or pathological conditions. Here, we discuss recent findings by Tu et al. in Molecular Cell that identify Pogo transposon‐derived gene POGK as tumor suppressor in triple‐negative breast cancer (TNBC) by regulating ribosome biogenesis and restricting cell growth. An isoform‐switch in TNBC results in the loss of POGK capacity to recruit the epigenetic corepressor TRIM28 and to exert its repressive functions. These findings shed light on the potential for TE‐derived genes in providing new therapeutic opportunities for highly malignant TNBC.
Mussel‐Inspired Highly Sensitive, Stretchable, and Self‐Healable Yarns Enabled by Dual Conductive Pathways and Encapsulation for Wearable Electronics
Authors: Zhao Songfang , Zhang Yongjing , Li Guolin , Zhou Yunlong , Xia Meili , Hoang Anh Tuan , Gao Yongju , Cao Duxia , Li Guoqiang , Li Yang , Lai Yuekun , Ahn Jong‐Hyun
Published: January 2025

Wearable electronic textiles, capable of detecting human motions and recognizing gestures, represent the forefront of personalized electronics. However, the integration of high stretchability, sensitivity, durability, and self‐healable/self‐bondable capabilities into one platform remains challenging. Herein, mussel‐inspired stretchable, sensitive, and self‐healable/self‐bonded conductive yarns enabled by dual electron transfer pathways and dual encapsulation technology are presented. Specifically, covered spandex yarns provide the necessary stretchability and adsorption capacity, while supramolecular polydopamine layer affords enhanced interfacial interactions. Reduced graphene oxide nanosheets and silver nanoparticle‐based sensing layers offer dual electron transfer pathways. Dual encapsulations with self‐healable/self‐bondable ability not only mitigate the crack propagation but also protect inner conductive materials from detachment. Benefiting from these rational designs, the composite yarns exhibit a large sensing range (158% strain), high sensitivity (22.88), low detection limit (0.0345%), fast response/recovery times (105/150 ms), and remarkable robustness (enduring 10 000 cycles at 20% strain). Furthermore, pressure sensors and sensing arrays are assembled by stacking conductive yarns perpendicularly using a self‐bondable function, and self‐healable helical‐structured conductors are fabricated through the shape‐memory effect. Important applications of multifunctional yarns in physiological motion detection, gesture recognition, and circuit connection are demonstrated. This concept creates opportunities for the construction of multifunctional and high‐performance wearable electronic textiles.
Highly Efficient and Universal Degradation of PD‐L1 via Mitochondrial Oxidative Stress Evoked by Cationic AIE‐Active Photosensitizers for Cancer Immunotherapy
Authors: Liu Jiazhe , Zhang Ruoyao , Bao Yixuan , Chen Yijun , Zheng Wenfang , Yuan Jianing , Zhang Zhuomiao , Chen Pu , Ji Meiju , Cheng Yangyang , Hou Peng , Dang Dongfeng , Ding Dan , Chen Chao
Published: January 2025

The blockade of interactions between programmed death‐ligand 1 (PD‐L1) on cancer cell surfaces and programmed cell death‐1 (PD‐1) receptors on T cells is a crucial strategy in cancer immunotherapy. However, the continuous replenishment of PD‐L1 from intracellular stores presents a significant challenge that undermines therapeutic efficacy. Therefore, effective downregulation of intracellular PD‐L1 is essential for improving treatment outcomes. In this study, a novel approach that utilizes mitochondrial oxidative stress to achieve highly efficient and universal PD‐L1 degradation is presented. A cationic aggregation‐induced emission‐active photosensitizer, DPA‐B‐YP+, which generates reactive oxygen species (ROS) upon light activation to induce mitochondrial oxidative stress on demand is developed. Compared to traditional high‐performance PD‐L1 degraders such as metformin and berberine, ROS‐induced mitochondrial stress by DPA‐B‐YP+ demonstrates superior efficiency and broader applicability in PD‐L1 degradation across various tumor types. Mechanistic studies reveal that PD‐L1 degradation by DPA‐B‐YP+ occurs via the AMPK‐ubiquitination pathway. Furthermore, in a murine immunogenic “cold” tumor model, DPA‐B‐YP+ effectively degrades PD‐L1 and significantly enhances CD8+ T cell‐mediated immune responses upon light activation, without the need for additional drugs or immune adjuvants. These findings present a novel approach and material for PD‐L1 degradation, contributing to advancements in cancer immunotherapy.
Recent Advances in Surface Functionalized 3D Electrocatalyst for Water Splitting
Authors: Meethale Palakkool Nadira , Taverne Mike P. C. , Bell Owen , Mar Jonathan D. , Barrioz Vincent , Qu Yongtao , Huang Chung‐Che , Ho Ying‐Lung Daniel
Published: January 2025

Hydrogen is gaining attention as a fossil fuel alternative due to its potential to meet global energy demands. Producing hydrogen from water splitting is promising as a clean and sustainable fuel pathway. The hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) are crucial in electrocatalytic water splitting for energy conversion and storage. However, water electrolysis faces challenges in cost, efficiency, and scalability. Alternative transition metal electrocatalysts and emerging 2D materials advance electrolysis research, though transitioning from academia to industry remains challenging. The introduction of 3D‐printing technologies has revolutionized electrode fabrication for HER and OER. This review explores integrating 3D‐printing technologies and surface functionalization with non‐noble metal‐based electrocatalysts and emerging 2D materials. It focuses on surface‐functionalized 3D‐printed electrodes using technologies like selective laser melting, stereolithography, and fused deposition modeling with non‐noble metal electrocatalysts such as transition metal oxides, hydroxides, and emerging 2D materials like transition metal carbide/nitride (MXenes) and transition metal dichalcogenides (TMDCs). The review highlights the opportunities and challenges in scalable fabrication, long‐term durability, and cost‐efficiency for practical implementation. Future research directions include exploring new materials for 3D printing and alternative electrocatalysts alongside leveraging theoretical and machine‐learning approaches to accelerate the development of competitive materials for water electrolysis.
Soil organic carbon in tropical shade coffee agroforestry following land‐use changes in Mozambique
Authors: Magalhães Tarquinio Mateus , Reckziegel Rafael Bohn , Paulino João
Published: January 2025

Coffee (Coffea L.) agroforestry systems (CAFS) and wooded grasslands (WG) have been pointed out as having high soil organic carbon (SOC) storage potential compared to monoculture systems. Studies analyzing the response of soil bulk density (BD) and SOC to the conversion of WG to slash‐and‐burn agriculture (SBA) and to CAFS are lacking in southern Africa. This study was conducted in the buffer zone of Gorongosa National Park (Mozambique), where depth profiles of BD and SOC were estimated to 0‐ to 100‐cm soil depth in WG, SBA, and CAFS sites, with coffee shrubs aged 3, 5, and 8 years after planting. The stratification ratio (SR) was used as an indicator of soil quality and recovery from disturbance. BD and SOC stocks varied significantly among land use systems and coffee ages only in the surface soil layer (0–20 cm). SOC stocks of the surface soil and SR increased with increasing coffee age. Compared to SBA, significant increases in SOC stocks were only observed 5 years after implementation of CAFS. WG conversion to SBA did not alter SOC stocks in any soil layer; however, it led to decreased SR. Surface SOC stocks were 25.6 and 33.7 Mg ha−1 in WG and SBA, and 28.0, 41.9, and 61.1 Mg ha−1 in 3‐ and 5‐ and 8‐year‐old CAFS (mean SOC accumulation of 6.65 Mg ha−1 year−1). This study reveals that CAFS have the potential to increase belowground carbon sequestration when compared to SBA and WG over comparable soils, making it a practical option for climate change mitigation.
Impact of Botfly Parasitism on the Behavior of Mantled Howler Monkeys
Authors: Ortíz‐Zárate Ricardo J. , Cristóbal‐Azkarate Jurgi , Rangel‐Negrín Ariadna , Coyohua‐Fuentes Alejandro , Dias Pedro A. D.
Published: January 2025

Parasitism, a widespread nutrient acquisition strategy among animals, results from a long evolutionary history where one species derives its metabolic needs from another. Parasites can significantly reduce host fitness, affecting reproduction, growth, and survivability. Vertebrate hosts exhibit defensive strategies against parasites, including “sickness behaviors” such as lethargy and self‐grooming to remove ectoparasites. In addition, social animals may engage in “helping sick animals” behaviors, such as social grooming, to aid parasitized group members. Mantled howler monkeys (Alouatta palliata) parasitized by botfly larvae (Cuterebra baeri) exhibit subdermal nodules, which can be fatal under nutritional stress. This study investigates whether mantled howler monkeys display sickness behaviors or helping behaviors in response to C. baeri parasitism. Observations from July 2022 to April 2023 in La Flor de Catemaco, Mexico, revealed that parasitized individuals did not increase the frequency of self‐directed (rub, scratch, and touch) nor received helping behaviors (social scratch and social touch) compared to non‐parasitized ones. However, parasitized monkeys were more active, spending more time feeding and moving, likely to compensate for the metabolic costs of parasitism. This shift from energy conservation to energy acquisition strategies suggests a complex response to parasitism, emphasizing the need for further research on the energetic impacts of parasitism in this species. These preliminary findings suggest behavioral flexibility by mantled howler monkeys in coping with infection, indicating potential adaptive strategies to mitigate the adverse effects of parasitism.
Stable Luminescent Diradicals: The Emergence and Potential Applications
Authors: Zhu Yujie , Zhu Zihao , Wang Saixue , Peng Qiming , Abdurahman Alim
Published: January 2025

Stable luminescent diradicals, characterized by the presence of two unpaired electrons, exhibit unique photophysical properties that are sensitive to external stimuli such as temperature, magnetic fields, and microwaves. This sensitivity allows the manipulation of their spin states and luminescence, setting them apart from traditional closed‐shell luminescent molecules and luminescent monoradicals. As a result, luminescent diradicals are emerging as promising candidates for a variety of applications. This minireview discusses recent advances in the design and synthesis of luminescent diradicals, explores their photophysical properties and potential applications. It also examines the challenges and prospects in the development of these materials, shedding light on their potential to drive technological innovation.
Accelerating Tumor Immunotherapy Through a Synergistic Strategy of Increasing Throttle and Relaxing Brake
Authors: Ding Binbin , Li Jing , Tan Jia , Chen Hao , Zheng Pan , Ma Ping'an , Lin Jun
Published: January 2025

Tumor immunotherapy has been widely used clinically, but it is still hindered by weak antitumor immunity and immunosuppressive tumor microenvironment (TME). Here, a kind of simple disodium hydrogen phosphate nanoparticle (Na2HPO4 NP) is prepared to “accelerate” tumor immunotherapy by “increasing throttle” and “relaxing brake” simultaneously. The obtained Na2HPO4 NPs release a large amount of Na+ and HPO42− ions within tumor cells, thereby activating the caspase 1/GSDMD‐mediated pyroptosis pathway to achieve immune activation. Meanwhile, alkalescent Na2HPO4 NPs can further consume lactic acid through acid‐base neutralization, and regulate adenosine (Ado) metabolism via nanomaterial‐induced biocatalytic process to relieve two‐tier immunosuppression. Collectively, Na2HPO4 NPs effectively activate the antitumor immune process in vivo, and dramatically inhibit primary and distal tumor growth. This work will provide unique inspiration and strategy for the regulation of both positive and negative directions in immunotherapy.
Preparation and Properties of Composite Water‐Absorbent Resin Based on Carboxymethyl Chitosan and Polyaspartate
Authors: Ge Tiejun , Li Jianyue , Liu Xiaofeng , Yu Yang , He Xiaofeng , Yue Qi
Published: January 2025

Carboxymethyl chitosan (CMCS) was grafted with acrylic acid (AA) and acrylamide (AM) to prepare CMCS‐AA‐AM, in which, polysuccinimide modified with KH550 was added to form polyaspartate (KPAsp) by aqueous polymerization method, so the composite water‐absorbent resin (CMCS‐AA‐AM/KPAsp) with a semi‐interpenetrating network structure was prepared. The optimum conditions were obtained as follows: m(KPSI): m(AA): m(AM): m(CMCS): m(KPS): m(MBA) = 0.8:10:2.5:1.0:0.08:0.012, and the neutralization degree of AA was 65%. The water absorption rate of the resin prepared under the optimum condition was 802.13 g.g−1, and that in 0.9% normal saline was 96.27 g.g−1, which were 1.55 and 1.29 times higher than that of CMCS‐AA‐AM resin, respectively. It was found that the addition of KPAsp resulted in greater porosity and surface area and good thermal stability. The composite water‐absorbent resin presented good performance of salt resistance, water retention, and reusability. Moreover, the swelling kinetics revealed the non‐Fick diffusion mechanism of the composite water‐absorbent resin. Compared with commercial petroleum‐based water‐absorbent resins, which are nondegradable, the composite water‐absorbent resin prepared in this paper exhibits good degradability based on the biodegradable raw materials of CMCS and KPAsp and also showed better absorption performance compared with the same type of water‐absorbent resins.
Copillar[5]arene Appended Pyrene Schiff Base: Photophysics, Aggregation Induced Emission and Picric Acid Recognition
Authors: Ghosh Subhasis , Ghosh Kumaresh
Published: January 2025

Herein, we report the synthesis of copillar[5]arene‐based pyrene Schiff base 1 and its characterization by using 1H, 13C NMR, FT‐IR and mass spectrometry. UV‐vis absorption, steady‐state fluorescence and time‐resolved fluorescence are done to elucidate the photophysical behaviors of 1. To understand the electronic structure of 1, density functional theory (DFT) calculations are performed. Owing to the presence of pyrene via a Schiff base linkage, compound 1 exhibits aggregation‐induced emission (AIE) characteristics. It shows aggregation in aqueous THF and DMF. The aggregation behavior is successfully demonstrated by steady‐state fluorescence, dynamic light scattering (DLS) and time‐correlated single‐photon counting (TCSPC) experiments. Experimental findings reveal that hydrophobic effect is the driving force in the formation of aggregates. As application, the aggregated state of 1 in aqueous THF fluorimetrically recognizes picric acid (PA) selectively over a series of nitro‐ and nonnitroaromatics with a detection limit of 1.62×10−7 M. The emission of the aggregated state is fully quenched upon interaction with PA.
Lewis base phase transfer catalyst promoted solvent‐free nucleophilic reactions in ionic liquids: Quantum chemical analysis for cooperative enhancement in SN2 reaction rates
Authors: Oh Young‐Ho , Lee Sungyul
Published: January 2025

We present quantum chemical analysis of Lewis base phase transfer catalyst (PTC) facilitated solvent‐free nucleophilic reactions in green solvent/catalyst ionic liquids (ILs). We adopt two nucleophilic processes: First, we examine whether and how the reaction rate of 18‐crown‐6‐promoted SN2 reaction is further enhanced by the IL [Bmim]OMs. Second, we examine the promotion of SN2 cynation by the IL‐integrated aza‐crown ether, and third, the SN2 fluorination facilitated by [2.2.2]‐cryptand in the IL. Interactions between the IL, PTC and the substrates are shown to give rise to lower Gibbs free energies of activation, with the IL anion (OMs−) acting as an additional Lewis base promoter on the counter‐cation M+, (M = K, Cs), thereby further mitigating the latter's disadvantageous influence on the nucleophile. We thus propose that the ILs may be used to facilitate the nucleophilic processes as solvent/ organocatalysts instead of environmentally malicious organometallic compounds.
Immunoinfiltration Analysis of Mitochondrial Damage‐Related Genes in Lung Adenocarcinoma and Construction of a Classification and Prognostic Model Integrated With WGCNA and Machine Learning Algorithms
Authors: Zhang Jirong , Lin Lin
Published: January 2025

Background

Lung adenocarcinoma (LUAD) exhibits molecular heterogeneity, with mitochondrial damage affecting progression. The relationship between mitochondrial damage and immune infiltration, and Weighted Gene Co‐expression Network Analysis (WGCNA)‐derived biomarkers for LUAD classification and prognosis, remains unexplored.

Aims

The objective of our research is to identify gene modules closely related to the clinical stages of LUAD using the WGCNA method. Based on the genes within these modules, we constructed machine learning (ML) models for classification and prognosis prediction, thereby facilitating precise diagnosis and personalized treatment of LUAD.

Materials & Methods

Using GeneCards and The Cancer Genome Atlas (TCGA) databases, we screened differentially expressed mitochondrial damage‐related genes in LUAD. Immune cell infiltration patterns were assessed using Single‐Sample Gene Set Enrichment Analysis (SSGSEA) method. Functional enrichment analyses were conducted to explore biological functions and signaling pathways. Gene modules related to clinical stages of LUAD were identified by WGCNA. ML models were constructed for classification and prognosis prediction, and validated in an independent Gene Expression Omnibus (GEO) dataset.

Results

The study revealed a significant relationship between mitochondrial damage and immune infiltration in LUAD. We identified a gene module closely associated with the clinical stages of LUAD. The ML models for classification and prognosis that were constructed demonstrated good effectiveness and generalization capabilities.

Discussion

Mitochondrial damage‐related genes are crucial in LUAD progression and linked to immune infiltration. The gene module and models identified have potential applications in LUAD classification and prognosis, offering novel markers for precision medicine.

Conclusion

This study uncovers the relationship between mitochondrial damage and immune infiltration in LUAD, paving the way for molecular classification, prognosis prediction, and personalized treatment strategies.
Cultivating a sense of curiosity is the best career advice for anyone
Authors: Skipworth Stan
Published: January 2025

As the new year gets underway for all of us, I decided to offer some insight on the importance of a good start to new goals and the opportunity to create a fresh start both professionally and personally. But I also wanted to, perhaps, go a little deeper in our quest to achieve new levels of personal and professional success.
Learn how to become a coaching leader to boost department engagement
Authors: McCarthy Claudine
Published: January 2025

If you want to enhance the individual performance of your staff members while cultivating a cohesive, motivated team that thrives, you’ll need to adopt a coaching leader mindset. That's according to Floyd Consulting CEO Kate Volman and Senior Executive Coach Michele Marquis. (Floyd Consulting offers coaching services to individuals and organizations, as well as training, speaking, and consulting.) In their webinar, they explained strategies to help you become a coaching leader, which can improve the success of your department.