bluuebunny/crossref_metadata_2025 huggingface dataset:
Diphtheria and the risk of outbreaks of vaccine-preventable diseases in low-resource settings
Authors: Adeyanju Gbadebo Collins , Frampton Sally , Hein Constanze
Published: February 2025

This study aims to highlight the complex and multifaceted nature of vaccination drivers, uptake, and hesitancy in the face of the recent outbreak of diphtheria in Nigeria and its significant impact on the regional and global burden of disease. The outbreak has highlighted the continuing threat and vulnerability of vaccine-preventable disease (VPD) outbreaks or epidemics due to the low vaccine uptake in the country and across Sub-Saharan Africa (SSA). This study first identifies recent drivers and challenges to vaccine uptake. It then promotes the need for regionally based, interdisciplinary approaches with a focus on visual communication strategies, particularly in low-literacy settings. Ultimately, visual communication strategies would benefit from a broader evidence base to better understand the effectiveness and impact of design in promoting vaccine uptake. The study recommends that in the Nigerian context, addressing the threat of VPD outbreaks should be embedded in communication strategies, especially when they are designed considering the local population. This should occur alongside strategies to reduce psychological impact factors like stress associated with travel time for vaccination and waiting time at healthcare facilities. Vaccination programs should be linked to local sources of safety or individuals with high credibility to increase trust; healthcare workers should stop exaggerating the effectiveness of vaccines to stimulate demand; and fathers should be considered an important target group in intervention programs.
Legal Education Between The Rules Imposed by Canon Law And Today’s Legislative System
Authors: Marin Marilena
Published: February 2025

This paper covers the evolution of legal education from its religious and cultural origins to contemporary influences, providing a broad framework for exploring the complexity between religious norms and modern legislation. The concept of ”education” presents a range of information that we can view from a general perspective as a form of training for individuals, as well as for professionals who apply the law. Through our study, we propose an analysis of the concept of ”legal education” as found in the fields of history and law, thus demonstrating the interdisciplinary approach of this endeavor.Starting from the general-specific connection, we initiated an analysis of the concept of legal education from the perspective of canon law and common law to outline a comprehensive opinion on the foundation we are presenting for discussion within our paper.The material we propose begins with the origin and evolution of the term "legal education" and continues with a brief terminological analysis. We further address the role of legal education throughout the ages, from antiquity to the present day, and the place, religious implications, and influence of religious texts on justice and legal education in each era.The chosen method is qualitative research through observation. In this context, we defined the subject of the research (legal education), analyzed the concepts (on the one hand, the concept of educating individuals about rules, norms, and justice, and on the other, the training of future professionals/public officials who interpreted and/or applied the law), and systematized the collected data to identify the utility of the concept of legal education in each era.By examining the information contained in this paper, we open up a topic that can be further developed by those interested in our subject.
Analysis of Resampling Methods for the Red Edge Band of MSI/Sentinel-2 for Coffee Cultivation Monitoring
Authors: Fagundes Rozymario Bittencourt , Bolfe Édson L. , Ramos-Ospina Manuela
Published: February 2025

Spectral indices such as NDRE (Normalized Difference Red Edge Index), CCCI (Canopy Chlorophyll Content Index), and IRECI (Inverted Red Edge Chlorophyll Index), based on the Red Edge band of MSI/Sentinel-2 (B05, B06, B07 images), are essential tools in coffee monitoring. These indices require resampling the Red Edge band (20 m resolution) to match the NIR (10 m resolution) using methods such as nearest neighbor, bilinear, cubic, and Lanczos. In this technical note, we evaluated these resampling methods using two original B05 images, selected on November 24, 2023, and September 21, 2023, with reference points from the farms "Ouro Verde" (15 hectares) in Barra do Choça (BA) and "Canto do Rio" (45 hectares) in Luís Eduardo Magalhães (BA), respectively. A total of 500 random points were generated and analyzed using PSF, linear models, and cross-validation with metrics such as R², MAE, and RMSE. The PSF analysis indicated the integrity of the data for further analysis. The cubic method showed the best performance (R² = 0.996, MAE = 20.87, RMSE = 32.67). The validation results of the resampling methods suggest that this procedure is crucial for accurate digital processing in remote sensing for coffee cultivation and should be aligned with the study objectives.
Digestion of PET Plastic by Genetically Modified E. Coli in Simple Batch Style Bioreactors
Authors: Bogroff Malcolm , Brogca Clemente
Published: February 2025

In light of the discovery of the bacteria Ideonella Sakaiensis in 2016, enzyme based recycling has become a very promising field of study. The bacteria was found in the sludge of a Japanese recycling plant and produced the enzyme PET hydrolase. This was one of the first enzymes discovered capable of breaking down type 1 plastic. As time went on, researchers began developing more efficient versions of PET hydrolase. Though it has amazing potential, its ability in a low fidelity setting is still unknown. In our study, we produced a series of low fidelity bioreactors to test the enzyme’s capabilities under stress. For our procedures, we used E. Coli modified with the pET21b(+)-Is-PETase plasmid [3] to produce the enzyme for our study. We conducted our experiment over the course of 4 weeks with 5 unique batch style bioreactors. In our research we were able to determine that E.Coli was able to decrease the weight of 0.6 grams (± 200 milligrams) PET plastic strips by 0.2 milligrams (± 0.1 milligram).

[M1]Refs. Citation are not allowed in abstract, please move them to maintext.
Plan de negocios servicio de maquillaje artístico con prototipado y efectos especiales FX para eventos especiales para Lima metropolitana
Authors:   , Solis Oclocho Emma Geovanna , Toribio Pisconte Diana Gabriela , Quispe Huamani Hermogenes , Carrion Pezo Jorge Washington
Published: February 2025

Este plan de negocios presenta una estrategia integral para el lanzamiento y consolidación de una empresa especializada en maquillaje profesional FX para eventos especiales en Lima Metropolitana. Identificamos una oportunidad de mercado significativa ante la escasez de profesionales calificados en esta área.
Mediante un análisis exhaustivo del entorno y de la competencia, hemos desarrollado un modelo de negocio sólido que se centra en la personalización, calidad y creatividad de nuestros servicios. Nuestras estrategias de marketing se enfocarán en posicionarnos como líderes en el mercado, utilizando canales digitales y tradicionales para llegar a organizadores de eventos, productoras audiovisuales y público en general. En el área operativa, hemos implementado procedimientos eficaces para la administración de proyectos, desde la consulta del cliente hasta la realización del servicio de maquillaje. Además, hemos escogido productos de excelente calidad y forjado alianzas estratégicas con proveedores de confianza.
En términos financieros, hemos elaborado un plan de negocio detallado que incluye proyecciones de ingresos y gastos, así como un análisis de rentabilidad. Nuestro objetivo es alcanzar la sostenibilidad financiera en un plazo de 5 años. En resumen, este plan de negocios proporciona una hoja de ruta clara para el crecimiento de nuestra empresa y la consolidación de nuestra marca en el mercado del maquillaje FX de Lima Metropolitana.
Factores asociados a la hospitalizacion de pacientes con Covid-19 en altura
Authors:   , Solar Loayza Maria Luisa
Published: February 2025

Introducción: En los últimos años se estima que las poblaciones de altitud tienen menor prevalencia e impacto de la infección por SARS-CoV-2. Objetivo: Determinar los factores asociados a la hospitalización por COVID-19 de la provincia de Chincheros, Apurímac–Perú (agosto 2020 - julio 2021). Materiales y métodos: Estudio observacional, transversal y analítico. Población conformada por 2278 pacientes residentes de Chincheros, Apurímac a una altitud ≥ 1 500 m.s.n.m. Para el análisis de datos se empleó frecuencias, medidas de tendencia central, prueba de Chi cuadrado, Exacta de Fisher, U de Mann-Whitney y regresión de Poisson para el cálculo de la razón de prevalencia cruda y ajustada. Resultados: La mediana de edad fue 41 años, 25,64% poseían alguna comorbilidad y se hospitalizaron un 7,86%. La razón de prevalencia ajustada fue estadísticamente significativa en: edad (RPa 1,05; p<0,001), altitud (RPa 0,9996; p=0,010), adulto (RPa 2,88; p<0,001), adulto mayor (RPa 11,74; p<0,001), elevada altitud (RPa 0,56; p=0,001), gran altitud (RPa 0,0000018; p<0,001), saturación de oxígeno (RPa 0,94; p<0,001), temperatura (RPa 1,86; p<0,001), frecuencia cardiaca (RPa 1,04; p<0,001), frecuencia respiratoria (RPa 1,10; p<0,001), comorbilidad (RPa 4,95; p<0,001), obesidad (RPa 2,81; p=0,003), diabetes mellitus (RPa 2,26; p=0,002), enfermedad cardiovascular (RPa 2,16; p=0,002) y asma (RPa 6,44; p<0,001). Conclusión: Los factores asociados a hospitalización por COVID-19 fueron edad, altitud, grupo etario, nivel de altitud, saturación de oxígeno, temperatura, frecuencia cardiaca, frecuencia respiratoria, tener alguna comorbilidad, obesidad, diabetes mellitus, enfermedad cardiovascular y asma.
Identification and understanding of precautionary legends in the Mexican warning labeling for sweetened beverages
Authors: Munguía Ana , Sagaceta-Mejía Janine , Cruz-Casarrubias Carlos , Durán Regina , Barquera Simón , Tolentino-Mayo Lizbeth
Published: February 2025

Objective. To evaluate the identification and objective understanding of precautionary legends regarding non-sugar sweeteners (NSS) and caffeine in sweetened beverages (SBs). Materials and methods. The labeling questionnaire from the National Health and Nutrition Survey 2021 was administered to Mexican adults over 20 years old. Identification was assessed when the participants reported seeing the legend. Objective understanding was determined by correctly evaluating the nutritional quality of SBs. For this evaluation, 50% of the participants were presented with an image of a sugary drink displaying the precautionary legend, while the other 50% without the legend. Results. For the NSS legend, the odds of correctly evaluating the nutritional quality of a SB were higher among participants who identified the NSS legend (OR: 1.62, 95%CI: 1.12,2.34) compared to those who did not. Similarly, the odds were higher when the product was presented with the legend compared to when it was not (OR: 1.23, 95%CI: 1.01,1.51). For the caffeine legend, the odds of correctly evaluating the nutritional quality of a SB were four times higher among participants who identified the legend compared to those who did not (OR: 3.97, 95%CI: 1.98,7.97). Conclusion. Greater effectiveness was observed among participants who identified the legends. We recommend implementing strategies to enhance the identification of precautionary legends.
Reconocimiento a revisoras y revisores 2024
Authors: Cuerpo editorial Salud Pública de México
Published: February 2025

No disponible
Direct Hydroxylation of Benzene to Phenol over Vanadium Oxide Supported on Carbon Fibers Felt Containing Nitrogen
Authors: Javadi Maryam Sadat , Ghiaci Mehran , Mahdavi Mohammad , Bahadorikhalili Saeed
Published: February 2025

Direct hydroxylation of benzene is a stable and promising strategy for phenol synthesis. In this project, VO (12.5 wt%)/N-CFF catalyst was synthesized by VO-nitrogen doped carbon and supported on carbon fibers felt simultaneously. The synthesized catalyst was characterized by XPS, BET, FESEM, EDX-mapping, XRD, TEM, TGA, Raman, FT-IR, UV-Vis, ICP analysis. catalytic performance of VO (12.5 wt%)/N-CFF was also investigated in both thermal and photocatalytic oxidation reactions of benzene to phenol under optimal conditions. The selectivity of 100% was obtained. The yield of phenol product in thermal oxidation and photocatalytic oxidation of benzene were 18.9 and 16.82 respectively. In these reactions acetonitrile was used as solvent and hydrogen peroxide was used as oxidant. Optimal conditions for thermal oxidation of benzene, 50 mg catalyst, 80°C temperature, 6 h time, molar ratio of H2O2/Benzene 2, were obtained. The reaction was performed under 5 bar N2 pressure. Optimal conditions for photocatalytic oxidation of benzene, 50 mg catalyst, 65°C temperature, 4 h time, molar ratio of H2O2/Benzene 2 and distance of visible light to reaction dish 20 cm were obtained. The synthesized catalyst is a bulk catalyst based on eco-friendly support with high performance and recyclability and easy separation of reaction.
Morphological, Anatomical, and Phytochemical Evaluation of Cissusquadrangularis I, Cissus quadrangularis II, Cissus rotundifoila and Cissus cactiformis
Authors: Mohan Sangeetha
Published: February 2025

These Medicinal plants collected from Tamil Nadu have very distinct and tedious external morphological features which could lead to chaos. To validate its taxonomy, anatomical structures, and phytochemical components are evaluated. Cissus rotundifolia, Cissus quadrangularis, and Cissus cactiformis are some of the abundantly available but less researched medicinal plants in Tamil Nadu, India. Numerous studies have been performed worldwide to describe the anatomical characteristics of the stem of the Cissus species. The selected Cissus species are from belong to the Vitaceae family and exhibit four distinct morphological variants. These variants differ significantly in their morphological and anatomical characteristics. According to the results of an external feature study, the stem of Cissus quadrangularis I is dark green in colour with quadrangular sides. Cissus quadrangularis II has a pale green stem with triangular, flat edges. The dark green stem of Cissus cactiformis features quadrangular sides with a serrated edge. These three Cissusvariations are stem-type variations, and their stems differ noticeably in appearance. Cissus rotundifoila, on the other hand, is a leaf-type variation. The microscope features analysis revealed a distinct difference in these plant varieties, such as vascular bundles, a layer of parenchymatous, collenchymatous, sclerenchymatous, phloem cells, and xylem vessel rows evident under the microscope feature of the transfer section. These features exhibit notable variations in each variant. The identification of four Cissus variations is made easier by this microscopic and exterior investigation. Additionally, the results of the GCMS analysis revealed the various new phytochemical elements. In conclusion, the four Cissus species under study have unique morphological features and phytochemical contents, and their conflict has unique medicinal qualities that are verified to identify the phytochemical investigations.
Development of Tissue Culture Techniques and Comparative Metabolomics for Echeveria laui Calli
Authors: Fu Shuangbin , Ying Zhen , Chen Chaoxiang , Yang Yanping
Published: February 2025

In recent years, the market for succulent plants has experienced rapid growth. To increase the yield and value of Echeveria laui, a member of the succulent family, a tissue culture method was established in this study. The highest callus induction rate (26.7%) was achieved on Murashige and Skoog (MS) medium supplemented with 3 mg·L−1 6-benzylaminopurine (6-BA), 1 mg·L−1 α-naphthaleneacetic acid (NAA), and 0.1 mg·L−1 thidiazuron (TDZ). The highest proliferation coefficient (4.26) was observed on medium containing 3 mg·L−1 6-BA and 1 mg·L−1 NAA. Seedlings were regenerated when calli were cultured on MS or 1/2 MS medium without plant growth regulators (PGRs). During proliferation, three distinct types of calli were identified and analyzed using morphological observations and widely targeted metabolomics. Morphological analysis revealed that regenerable calli (GCs) presented numerous granular buds on their surface, and the cells were regular and complete, contributing to their regenerability. Metabolomic analysis revealed that the differentially accumulated metabolites (DAMs) were primarily amino acids and their derivatives, with dUMP identified as a biomarker for dis- tinguishing among the three callus types. Additionally, changes in phytohormone levels were observed across the different callus types. These findings provide a valuable reference for optimizing culture systems, minimizing undesirable tissue changes, and enhancing propagation efficiency.
In Silico Study of Argan Oil Metabolites: Evaluation of Their Potential to Inhibit Key Receptors Activated by Excessive Alcohol Consumption and Involved in Cell Death
Authors: Bekkouch Ayoub , Bekkouch Oussama , Ziani Anas , Bentouhami Nour E. , Abouyaala Oumaima , marouane marouane El arbaoui , mostafi hicham el , Hamzaoui abdelghafour , Hesni Aboubaker el , Mesfioui Abdelhalem
Published: February 2025

Excessive alcohol consumption is a well-established cause of liver injury and neurodegeneration, driven by oxidative stress, inflammation, and apoptosis. This study explores the potential of Argania spinosa (argan oil) metabolites as natural inhibitors of key receptors involved in alcohol-induced cellular damage: NOX4 (NADPH Oxidase 4), PARP (Poly ADP-ribose Polymerase), and CCR2 (C-C Motif Chemokine Receptor 2). Using in silico approaches, including molecular docking, ADMET analysis, and molecular dynamics simulations, we systematically evaluated the interactions between twenty previously reported argan oil metabolites and these receptors.
Among the analyzed compounds, spinasterol emerged as the most promising bioactive molecule, demonstrating high binding affinity and structural stability within the receptor active sites. Molecular interaction analysis revealed strong hydrophobic interactions, π-π stacking, and hydrogen bonding, contributing to receptor inhibition. These findings suggest that spinasterol could modulate inflammatory and oxidative pathways, reducing alcohol-induced cellular stress.
This study underscores the potential of argan oil metabolites as natural therapeutic agents for preventing and mitigating alcohol-related pathologies. Future in vitro and in vivo investigations are necessary to validate these computational results and explore the translational potential of these compounds in clinical settings. The findings contribute to advancing plant-based drug discovery and natural pharmacological interventions for alcohol-induced disorders.
Recovery of Au(III) from electronic waste using solid phase extraction based on a magetic nanobiocomposite, OCBS@Fe3O4 @UiO-66-SH
Authors: Poormoghadam Parisa , Bahar Soleiman , Naghdi Yunes
Published: February 2025

This study created a zirconium-based MOF (UiO-66-NH2) with thiol groups attached to its magnetic corn surface for adsorption and extraction of Au(III) from electronic waste. Characterization of the composite was verified using FTIR, XRD, FESEM, TGA and BET techniques. The temperature, adsorption period, and pH on Au(III) adsorption were investigated. The pH of solutions significantly impacts Au(III) adsorption, with pH 6.0 being the optimal value. The optimum Au(III) adsorption conditions were 50 ◦C, 40 min, and 10 mg of adsorbent. Moreover, functionalized oxidized magnetic corncobs with thiol (OCBS@Fe3O4@UiO-66-SH) showed a notable ability to adsorb Au(III) with a 1587 mg/g capacity. With mass ratios of Au(III) to competing ions (Mg, Mn, Cu, Zn, Co, Cd, and Ni) fixed at 1:1 or extended to 1:5, this adsorbent prefers Au(III) ions while showing negligible adsorption to other ions. The study validated a technique for extracting Au(III) from various electronic waste samples, achieving high recovery rates (95.30–104.75%), demonstrating its effectiveness and lack of matrix interference. Langmuir, Freundlich, and Temkin isotherm models were used to describe the adsorption process. Comparing models, the Langmuir model with the most excellent R2 value is best for interpreting experimental adsorption data. Among three kinetic models, pseudo-first-order (PFO), pseudo-second-order (PSO) kinetic, and interparticle diffusion (ID) models, PFO model exhibited a high R2 value (0.9976). Thermodynamic calculations reveal a positive ΔH°, indicating the endothermic process, and negative ΔG° values representing spontaneous adsorption at 298–323 K. The positive ΔS° shows that the adsorbed molecules are more uniformly dispersed on the surface, potentially enhancing the adsorption capacity.
The Effect of Placental Mesenchymal Stem Cells on The Protection of Chronic Renal Failure: The Role of Adiponectin
Authors: Akan Ezgi , Sakıncı Mehmet , Suleymanlar Gultekin , Korgun Emin Türkay , Kipmen-Korgun Dijle
Published: February 2025

Purpose
Chronic glomerular and tubulointerstitial fibrosis is the leading cause of end-stage renal failure. Mesenchymal stem cell therapy shows great potential for kidney tissue regeneration. The use of measurable biomarkers is crucial for assessing the therapeutic effects of mesenchymal stem cells. Adiponectin is among the suggested biomarkers for monitoring the progression of chronic renal failure.
Methods
We extracted mesenchymal stem cells from the amnion membrane of term placentas. To establish the experimental groups, we partially ligated the left kidneys of male Wistar rats, fully removed the right kidney after two weeks, and observed them for an additional eight weeks. At the end of this period, the animals underwent a subtotal nephrectomy. After forming 5/6 nephrectomy, we transplanted stem cells via rat tail vein and waited for 15 and 30 days to form stem cell groups. We measured protein levels and mRNA expressions of Adiponectin, Adiponectin Receptor 1, Fibronectin and AMPK phosphorylation by western blot and Real-Time PCR methods respectively. Besides, urine and serum levels of adiponectin and urine levels of albumin measured by using a rat specific ELISA.
Results
Protein and mRNA expressions of Adiponectin, AdipoR1, Fibronectin, and AMPK phosphorylation were elevated in the nephrectomy groups compared to the controls; however, these increased gene and protein expressions declined following stem cell administration.
Conclusion
mesenchymal stem cells may have a therapeutic effect on chronic renal failure, and adiponectin may serve as a biomarker for monitoring disease progression.
How to raise a patriot in a modern school (from the experience of a history teacher)
Authors: Illarionova Liubov Iurevna
Published: February 2025

The article discusses the methods of patriotic education of schoolchildren in a modern school. The long-term experience of a history teacher in a rural school is revealed. The author gives examples of fostering patriotism in history lessons based on the study of family history and native land. The important role of conducting design and research activities with students is shown. The importance of extracurricular activities dedicated to the heroic pages of Russian history is revealed. The role of the school museum for the education of the modern generation is emphasized. The role of the students themselves in attracting the interest of the younger generation in the history of the Fatherland is raised. The author emphasizes the important role of the teacher's personality for the education of patriotic feelings of schoolchildren.
A Review of Anticancer Activity of Ferula Constituents and their Action Mechanism
Authors: Zare-Bidoki Reza , Afrasiabi Ali , Hajatmand-Targhi Fatemeh Zahra , Rahimi Hossein , Bagheri Seyyed Majid
Published: February 2025

Background:

Cancer is a challenging and lethal illness, with the number of individuals affected on
the rise, particularly in developing nations. This disease incurs significant expenses for both patients and governments
annually. Conversely, even with various methods and treatments in use, the mortality rate remains elevated.
Additionally, traditional therapies come with numerous side effects, and drug resistance presents
another obstacle for physicians. Consequently, discovering new drugs derived from natural sources may be a
method to combat cancer. Ferula plants contain different metabolites, including monoterpenes, sulfide compounds,
and polyphenols that are beneficial in cancer therapy.

Objective:

This article was assembled to gather evidence and literature concerning the anti-cancer properties
of compounds derived from these plants.

Methodology:

This review article was created by exploring the term Ferula isolated constituents and cancer,
with related data gathered from electronic databases such as ISI Web of Knowledge, PubMed, and Google
Scholar up until early 2024.

Results:

Results revealed that quite extensive research has been done in this area, indicating that the compounds
may serve as novel medications for cancer therapy.

Conclusion:

Subsequent research should encompass animal studies or clinical trials, focusing on assessing
toxicity and identifying effective doses against cancer to facilitate the application of these natural derivatives
in cancer treatment.
Amyloid-β Clearance with Monoclonal Antibodies: Transforming Alzheimer’s Treatment
Authors: Fatima Rabab , Khan Yumna , Maqbool Mudasir , Ramalingam Prasanna Srinivasan , Khan Mohammad Gayoor , Bisht Ajay Singh , Hussain Md Sadique
Published: February 2025

Alzheimer's disease (AD) is a progressive condition that causes the degeneration of
nerve cells, leading to a decline in cognitive abilities and memory impairment, significantly affecting
millions around the globe. The primary pathological feature of AD is the buildup of amyloid-β
(Aβ) plaques in the brain, which has become a major target for therapeutic strategies. This thorough
review examines the progress made in next-generation therapies that concentrate on monoclonal
antibodies (mAbs) aimed at Aβ. We explore how these antibodies function, their effectiveness
in clinical settings, and their safety profiles, specifically discussing notable mAbs, such as aducanumab,
donanemab, lecanemab, etc. This review also addresses the difficulties related to Aβ--
targeted treatments. Furthermore, it examines the advancing field of biomarker development and
tailored medicine strategies designed to improve the accuracy of AD treatment. By integrating the
latest findings from clinical trials and new research, this review offers an in-depth evaluation of
the possibilities and challenges associated with mAbs in modifying the progression of AD. Future
considerations regarding combination therapies and novel drug delivery methods are also examined,
emphasizing the necessity for ongoing research to achieve significant advancements in
managing AD. Through this review, we seek to provide clinicians, researchers, and policymakers
with insights into the current landscape and future directions of Aβ-targeted therapies, promoting
a deeper understanding of their role in addressing AD.
Antibacterial, Antibiotic-Potentiating, and Antiviral Activities of Selected Endemic Primary Rainforest Plants of Peninsular Malaysia
Authors: Zulkipli Masyitah , Sulaiman Mazdida , Elbehairy Layane , Jin Khoo Teng , Abdullah Nor Hayati , Raju Chandramathi Samudi , Kathirvalu Gheetanjali , Nissapatorn Veeranoot , Rusdi Nor Azizun , Saikim Fiffy Hanisdah , Zarubaev Vladimir , Rafon John Kenny , Villegas Jhonnel , Wiart Christophe
Published: February 2025

Background:

There is a need to identify original molecules to develop drugs for the
treatment of microbial infections. Such chemical entities could be found in secondary metabolites
of rainforest plants that are not so well-known. This study examines the antibacterial and antibiotic-
potentiating effects, and antiviral activities of six rainforest plants endemic to the primary
rainforest of Malaysia.

Methods:

Leaves, bark, fruits, and wood of Burkillanthus malaccensis, Cleistanthus bracteosus,
Diospyros hasseltii, Kibatalia maingayi, Knema retusa, and Litsea spathacea were extracted successively
with hexane, chloroform, and methanol, and tested against six human pathogenic bacteria
species by disc diffusion and broth microdilution. The extracts were tested against influenza
virus A/Puerto Rico/8/34 (H1N1) using MDCK cells.

Results:

Of the 42 extracts tested, the hexane extract of fruits of D. hasseltii inhibited the growth
of E. coli with the MIC value of 39 μg/mL. The chloroform extract of leaves of C. bracetosus potentiated
the activity of levofloxacin against P. aeruginosa. The strongest antiviral activity was observed
with the chloroform extract of leaves of C. bracteosus with the IC50 value of 6.3 μg/mL.
The chloroform extract of bark of B. malaccensis with the IC50 value of 0.6 μg/mL was the most
cytotoxic.

Conclusion:

Preserving the primary rainforest of Malaysia is a means to preserve natural products
with the ability to be developed as antimicrobial leads. In particular, D. hasseltii, C. bracteosus,
and B. malaccensis could be examined for their active antimicrobial constituents.
Investigating the Perceived Care Burden of Nurses Caring for COVID-19 Patients
Authors: Mirrashidi Fateme Sadat , Askarpour Hedie , Shokoufamanesh Ayuob , Raesi Rasoul , Hushmandi Kiavash , Razzaghi Alireza , Shafaei Fatemeh , Daneshi Salman
Published: February 2025

Background:

The widespread of COVID-19 was associated with major care challenges
for the health system. The burden of care was one of the treatment challenges for these patients, and
its impact on the treatment staff, especially nurses, is known as one of the important issues of the
COVID-19 pandemic.

Aim:

The aim of this study determining the care burden perceived by nurses caring for hospitalized
patients in the COVID-19 wards.

Methods:

This is a cross-sectional study that was conducted in 2022 by census method on 200 nurses
caring for patients hospitalized in the COVID-19 wards in Imam Khomeini and Kashani Jiroft hospitals
Jiroft. The data were collected with Novak and Guest's (1989) standard care burden questionnaire
and were analyzed using statistics of Kolmogorov Smirnov-Test, T-Test of two independent
samples, and analysis of variance in statistical software SPSS-v-22.

Results:

The average age of nurses was 28.58 ± 5.4. The average burden of care in nurses was 66.6 ±
6.8, that is, in the average range. There was a positive relationship between the age of nurses and
their care burden. The average burden of care was similar in both sexes. There was a significant relationship
between marital status and the decrease in income with the care burden of nurses.

Conclusion:

Health policymakers need to continue monitoring the care burden and well-being of
nurses during the COVID-19 pandemic and beyond. This will help ensure that appropriate measures
are in place to support nurses and maintain a high standard of care for patients.
Ankylosaurians from Coahuila, Mexico
Authors: Rivera-Sylva Héctor E. , Aguillón-Martínez Martha C. , Guzmán-Gutiérrez José Rubén , Flores-Ventura José
Published: February 2025

The fossil record of Ankylosauria is well-documented in several regions of the world yet remains relatively scarce in Mexico. Here we report new thyreophoran material from the Late Cretaceous in Coahuila, northeastern Mexico. The specimens, which include isolated osteoderms and partial skeletal elements, contribute to our understanding of the diversity, paleobiogeography, and paleoecology of this dinosaur clade in North America. Morphological comparisons suggest affinities with nodosaurid ankylosaurs, expanding their known range and ecological roles in the region. This discovery highlights the importance of Coahuila as a key locality for studying dinosaur faunas at the southern margin of the Western Interior Seaway.
La conservación del patrimonio arquitectónico de la universidad
Authors: Cortés Rocha Xavier
Published: February 2025

El patrimonio arquitectónico de la Universidad Nacional Autónoma de México es riquísimo por su belleza y funcionalidad urbanística, como es la Ciudad Universitaria que fue declarada Patrimonio Cultural de la Humanidad por la UNESCO en 2007, así como la serie de recintos y edificios, ubicados en el Centro Histórico de la Ciudad de México, que a la fecha conserva, reestructura y mantiene con renovado esfuerzo y entusiasmo y que le dan ese abolengo y tradición que ninguna otra universidad del país tiene y que, confirman su importancia y refrendan su vocación.

La historia de cada edificio, las acciones de intervención y restauración arquitectónica fundamentales para su preservación, es un compromiso que tiene la UNAM con el patrimonio, herencia material de los mexicanos. Sobre esta labor nos habla el Dr. Xavier Cortés Rocha, Profesor Emérito de la Facultad de Arquitectura, integrante de la Academia de Artes y Premio Nacional de Arquitectura.
Ética robótica ante la inteligencia artificial
Authors: Miklos Ilkovics Víctor
Published: February 2025

El desarrollo de la Inteligencia Artificial (IA), sin duda, es exponencial y avasallador, lo que conlleva a una transformación en todos los ámbitos de la administración pública, de las empresas y los gobiernos, pero también nos confronta con una serie de riesgos, principalmente éticos, regulatorios y de ciberseguridad. Una manera importante para incidir en los retos que la inteligencia artificial representa es introducirnos en la reflexión sobre las implicaciones éticas, científicas y sociales que conlleva, y para ello, el maestro y contador público Víctor Miklos Ilkovics, experto en el tema y excelente narrador, nos lleva a mirar, desde distintos ángulos y perspectivas, la ética robótica en la inteligencia artificial.
Decision-making process in choosing distribution strategy and channels
Authors: Bellaqa Bashkim , Beha Fejzula , Bajrami Halil
Published: February 2025

The primary goal of this research is to identify and examine logical decision-making, intuitive decision-making, and business conversations in the selection of product distribution channels in Kosovo. The study’s findings indicate that logical decision-making, intuitive decision-making, and business discussions have little influence on the selection of product distribution channels in Kosovo firms. Kosovo’s trade deficit in 2022 was 4.7 billion euros, or 20.1 percent higher than in 2021. Total exports in 2022 were 920.4 million euros, with imports being 5.6 billion euros (Kosovo Statistics Agency [ASK], 2024). The issue of establishing marketing mix instruments in Kosovo is linked to the country’s economic development. The use of rational decision-making and efficient management of distribution policies and strategies, in which, in addition to other measures within the framework of marketing and distribution development policies, the choice of distribution channels (CDC) is critical in the use of efficient product distribution channels in enterprises. The study recommends that marketing policy and strategy makers, with a special focus on the distribution instrument, manage policies and make productive decisions to create efficient distribution channels for enterprises in Kosovo and abroad, where distribution channel development is still at a low level, among other things.
Rettsoppgjøret i Ukraina: de største utfordringene
Authors: Nuridzhanian Gaiane , Helmersen Sondre Torp
Published: February 2025

Achieving justice for atrocity crimes and human rights breaches committed during Russia’s aggression against Ukraine is a complex and formidable task. This article examines key legal challenges in achieving justice for victims of Russia’s war and discusses the significance of accountability for atrocity crimes and other breaches of international law. Four aspects of the accountability process are in focus, namely: 1) War crime trials in national courts (in Ukraine and abroad), 2) Investigations by the International Criminal Court, 3) The establishment of a special tribunal for crimes of aggression, and 4) Russia’s responsibility as a state. The fragmented nature of existing international law mechanisms complicates the task of achieving comprehensive justice and securing reparations for the large-scale destruction and widespread harm caused by Russia’s full-scale invasion. Justice, however, demands that the task is achieved. Justice is crucial for victims of atrocity crimes and human rights violations committed in Ukraine. In addition, accountability for aggression against Ukraine is decisive for the future effectiveness of international law rules designed to protect states’ sovereignty and territorial integrity. What is more, accountability processes before international courts and tribunals can help to counter Russian disinformation and propaganda, key tools of Russian hybrid warfare.
ГЕОМЕТРИЗИРОВАННАЯ ФИЗИКА ВАКУУМА. ЧАСТЬ 10: ГОЛЫЕ «ПЛАНЕТЫ» И «ЗВЕЗДЫ»
Authors: БатановГаухман Михаил
Published: February 2025

Данная статья является десятой частью научного проекта под общим названием «Геометризированная физика вакуума на основе Алгебры сигнатур» [1,2,3,4,5,6,7,8,9]. В этой статье с использованием набора точных решений расширенного вакуумного уравнения Эйнштейна предложены метрико-динамические модели стабильных сферических вакуумных образований планетарного масштаба с радиусом ядра порядка r4 ~ 100 – 1000 км. Данные электрически нейтральные вакуумные образования названы голыми «планетами» и «звез-дами». Концепция голой «планеты» подразумевает, что в этой статье не учитывается наличие и влияние мелких вакуумных образований (микро-, нано- и пикоскопических «частиц»), рассматриваются только искривления вакуума звездно-планетарного масштаба. В частности, предложены метрико-динамические модели голой «звезды» и голых «планет» Солнечной системы. Показана аналогия между голой «Солнечной системой» и биологической клеткой. Как и весь проект данная статья направлена на реализацию программы полной геометризации физики Клиффорда-Эйнштейна-Уилера.
Анализ динамики очагов полиграфа уссурийского в границах темнохвойных лесов Красноярского края
Authors: Федонова Полина , Попова Валентина
Published: February 2025

Полиграф уссурийский представляет особую опасность для темнохвойных лесов. В Красноярском крае, где темнохвойные леса играют ключевую роль в поддержании биоразнообразия и экологического баланса, распространение полиграфа уссурийского стало масштабной проблемой, в результате которой происходит полная деградация лесной экосистемы. Проведен анализ динамики площадей очагов полиграфа уссурийского за 10-летний период на территории Красноярского края по данным государственного лесопатологического мониторинга
PENGARUH MODEL PROBLEM BASED LEARNING (PBL) BERBANTUAN MEDIA PHET TERHADAP HASIL BELAJAR FISIKA SISWA SMA
Authors: Andayuni Rizka Isnaini Putri , Derlina Derlina
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh model problem based learning  (PBL) terhadap hasil belajar fisika siswa SMA. Penelitian ini termasuk jenis penelitian quasi experiment dengan bentuk desain Two Group Design dengan dua kelas yaitu kelas eksperimen dan kelas kontrol. Populasi penelitian ini terdiri dari 7 kelas IPA dan pengambilan sampel dilakukan dengan purposive sampling yaitu teknik penentuan sampel dengan pertimbangan atau seleksi khusus. Sampel pada penelitian ini yaitu X IPA-4 sebagai kelas eksperimen dan X IPA-5 sebagai kelas kontrol berjumlah 33 dan 30 orang siswa. Instrumen yang digunakan dalam penelitian ini adalah tes hasil belajar dalam bentuk essai sebanyak 8 soal. Analisis data dilakukan dengan uji normalitas, uji homogenitas, dan uji hipotesis menggunkan uji t. Hasil penelitian diperoleh bahwa nilai  Pretes dan Postes kelas eksperimen adalah 29,79 dan 76,39 sedangkan nilai  Pretes dan Postes kelas kontrol adalah 28,90 dan 68,03. Analisis data menggunakan uji t disimpulkan bahwa ada pengaruh model pembelajaran PBL terhadap hasil belajar fisika siswa SMA.Kata Kunci: Problem Based Learning, Hasil Belajar.
PENGEMBANGAN LKPD BERBASIS REACT (RELATING, EXPERIENCING, APPLYING, COOPERATING, & TRANSFERING) PADA MATERI GELOMBANG BUNYI
Authors: Siregar Sri Hertati , Amdani Khairul
Published: February 2025

Penelitian ini bertujuan untuk mengetahui tingkat kelayakan, kepraktisan, dan keefektifan dari LKPD yang telah dikembangkan berbasis REACT pada materi gelombang bunyi kelas XI SMA Negeri 1 Bilah Hulu. Jenis penelitian ini adalah penelitian pengembangan atau Research and Development (R&D) menggunakan model 4D oleh Thiagarajan. Model 4D Thiagajaran terdiri dari empat tahap yaitu define, design, develop, dan disseminate. Hasil dari penelitian ini menunjukkan bahwa LKPD berbasis REACT pada materi gelombang bunyi yang telah dikembangkan dikategorikan “sangat layak” dengan rata-rata nilai kelayakan 86,72% ditinjau dari hasil validasi materi dan media.  LKPD dikategorikan “sangat praktis” ditinjau dari hasil uji coba yang dilakukan kepada 30 siswa Kelas XI MIA 1 dengan rata-rata kepraktisan 97,27%. Penilaian keefektifan LKPD melalui kegiatan pretest-posttest diperoleh skor N-gain sebesar 0,73 berkategori “Tinggi”. Dengan nilai rata-rata pretest 26,67 dan nilai rata-rata posttest sebesar 80,19. Dengan demikian disimpulkan bahwa LKPD berbasis REACT layak, praktis, dan efektif digunakan dalam meningkatkan hasil belajar siswa pada materi gelombang bunyi.Kata kunci: Pengembangan, LKPD, REACT, gelombang bunyi
Abordaje interdisciplinario en una tesis doctoral. Una investigación sobre Historia del Pasado reciente, Sociología Rural y Antropología de la Educación
Authors: Morzilli Melina
Published: February 2025

El presente trabajo tiene como objetivo general aportar al campo de los estudios sobre abordajes interdisciplinarios en ciencias sociales y humanas. En este sentido, aquí vamos a subrayar la relevancia de una propuesta interdisciplinaria (Notario, 2021), que pone en interrelación el campo de la Historia del Pasado Reciente, la Sociología Rural y la Antropología de la Educación en el marco de una tesis doctoral (Morzilli, 2019), perteneciente a un doctorado en Historia. Esta investigación sólo pudo concretarse mediante este abordaje interdisciplinario, al estudiar fenómenos sociales complejos. Para ello, daremos cuenta de las metodologías, las técnicas y fuentes que se implementaron y utilizaron para cada uno de los objetivos de la tesis, con la intención de visualizar cómo sólo a través de esta manera interdisciplinaria de abordarla se logró alcanzar sus objetivos. Por último, se realizarán reflexiones sobre la relevancia de la propuesta del abordaje interdisciplinario.
Analisis Qs. Az-Zariyat Ayat 19 dalam Pengimplementasian Hak dan Kewajiban Warga Negara
Authors: Chotimah Chusnul , Samsudin Arif , Dianur Khilwa Addina , Anbiya Bakti Fatwa
Published: February 2025

Al-Qur’an menjadi sumber pedoman hidup bagi umat muslim yang mengimani Allah Swt. Penelitian ini menggali makna ayat 19 Surat Az-Zariyat dalam pembangunan sosial, politik, dan ekonomi kontemporer melalui kacamata ajaran Al-Qur’an. Dengan menggunakan analisis tekstual, tinjauan literatur, konsultasi dengan ulama Islam, dan studi kasus, penelitian ini mengeksplorasi implikasi praktis prinsip-prinsip Al-Qur’an terhadap upaya pembangunan modern. Tema-tema utama seperti keadilan, tanggung jawab sosial, dan solidaritas komunal dikaji, menyoroti relevansinya dengan pembangunan berkelanjutan. Dengan menjelaskan contoh-contoh konkrit, penelitian ini menunjukkan bagaimana prinsip-prinsip Al-Qur’an dapat memandu kebijakan dan praktik yang mendorong keadilan sosial, keadilan politik, dan kemakmuran ekonomi. Temuan ini menggaris bawahi pentingnya ajaran Al-Qur’an dalam mengatasi tantangan pembangunan saat ini dan menekankan perlunya mengintegrasikan nilai-nilai Islam ke dalam strategi pembangunan. Tujuan dibuatnya artikel ini adalah sebagai bentuk penelitian dalam meneliti hubungan surat Az-Zariyat ayat 19 yang ada di Al-Qur’an dengan hak dan kewajiban bernegara. Karena hal-hal yang bersumber dari Al-Qur’an dapat menjadi sebuah acuan untuk membatasi dan menjadi petunjuk dalam permasalahan sosial serta perkembangan sosial. Metode dalam penelitian ini akan menggunakan metode kualitatif yang dapat menghasilkan suatu kajian mendalam dengan cara meneliti lebih dalam sumber-sumber yang berkaitan dengan tema penelitian ini. Oleh karena itu, tema penelitian ini diangkat dalam sebuah artikel untuk mengulas hak-hak dan kewajiban bernegara dalam perspektif Islam yakni yang ada pada surat Az-Zariyat ayat 19 tersebut.
The Effective Business Model: some Theoretical and Practical Considerations
Authors: Mihaylova Lyudmila , Papazov Emil
Published: February 2025

Companies operating in the modern era must continuously adjust their activities in response to the ever-shifting reality of the market. This includes the effects of competition, customer demand for new products and services, and other factors. Under these conditions, it is of utmost importance to analyze the distinctiveness of business models. This study provides an overview of the most important methodological and practical components of business models that are used in the contemporary management of companies.

This paper presents an overview of the business model, detailing its fundamental characteristics. It seeks to clarify the interconnections among business models, strategies, tactics, and operations in business development management. Finally, the paper focuses on factors that delineate a successful business model within the competitive landscape of complicated product offerings.
Russian Language in the Coordinates of Glocalization: Content Modeling in Linguistics and Translation Studies
Authors:   Volgograd State University, Fadeeva M.
Published: February 2025

The article covers the study of the functional potential of Russian, one of the most popular languages of interethnic com­munication within the framework of creating website’s translat­ed versions. The relevance is dictated by the possible quality improvement of Internet communication by modeling the pro­cess of forming a Russian-language Internet resource oriented to the glocal recipient. The research aims to analyze the tran­screation’s features of verbal content into Russian clear language for non-native Russian users. Structural-semantic, stylistic, dis­course and content analysis methods were applied in the re­search. The findings show that localization of the website can be done via machine translation, but post-editing should be per­formed. Texts with simplified lexico-grammatical and syntactic characteristics have a high degree of translatability. The results of the study can be used in the development of the concept of linguistic and translation support of the Russian-language ver­sion of the website of an Iranian foreign organization.