bluuebunny/crossref_metadata_2025 huggingface dataset:
TUMORES INTRACRANIANOS NA MICRORREGIÃO DE SAÚDE DE MANHUAÇU: UMA ANÁLISE EPIDEMIOLÓGICA
Authors: Yan Ker Marrara Peixoto  , Alex Nagem Machado  , Rafael Perígolo Vicente  , Natália Tomich Paiva Miranda  , Tatiana Vasques Camelo dos Santos  , Thiara Guimarães Heleno de Oliveira Pôncio  , Gustavo Henrique de Melo da Silva  , Gladma Rejane Ramos Araújo da Silveira
Published: August 2024

Os tumores do sistema nervoso central podem acometer todas as faixas etárias, com potencial de malignidade e classificação histopatológica heterogênea. O objetivo do presente estudo é expor a epidemiologia de tumores intracranianos na microrregião de saúde de Manhuaçu – Minas Gerais, e contribuir para uma melhor caracterização da epidemiologia desse grupo de patologias no Brasil. Para tal, foram considerados 73 casos de tumores intracranianos, que foram categorizados quanto à idade, sexo, principal sintomatologia e tipo histológico do tumor. A idade média foi de 47,38 anos, sendo a mínima de 6 anos e a máxima de 76 anos, com maior prevalência na faixa etária de 39 a 59 anos. O sexo feminino representou 58,9% dos casos e o sexo masculino 41,1%. Os principais sintomas apresentados foram cefaleia (39,7%), crise convulsiva (31,5%) e alteração motora (12,3%). Quanto ao diagnóstico, dentre os 73 casos foram identificados 21 tipos histológicos, sendo os gliomas (52,1%) e os meningiomas (19,2%) os grupos mais prevalentes. Dentro do grupo dos gliomas, o tipo histológico mais prevalente foi o glioblastoma multiforme (39,4%). Os dados encontrados foram correlacionados com outros relatos da literatura e encontradas similaridades e disparidades. Ressalta-se a necessidade de estudos epidemiológicos voltados às entidades descritas, no cenário brasileiro, pois tais informações possibilitam a abordagem mais individualizada do paciente, assim como o diagnóstico e terapêutica precoce, contribuindo para a saúde pública.
LEVANTAMENTO DE INFORMAÇÕES DA RELAÇÃO ENTRE A PRESTAÇÃO DE SERVIÇOS DE ASSISTÊNCA TÉCNICA COM O RESULTADO DA INCIDÊNCIA DA MASTITE NA PRODUÇÃO LEITEIRA DE PROPRIEDADES DA REGIÃO DA ZONA DA MATA MINEIRA
Authors: Maria Larissa Bitencourt Vidal  , Jefferson Luiz Ventura  , Marco Aurélio Prata
Published: August 2024

Inúmeros fatores tornam a produção de leite um entrave, desde questões ligadas a propriedade, nível de conhecimento e ao controle sanitário do rebanho, principalmente voltado ao manejo dos animais. O objetivo deste trabalho é identificar os fatores que interferem e levam ao desenvolvimento de mastite na produção leiteira da Zona da Mata Mineira, região Caparaó. As atividades do estudo foram por meio de um modelo de questionário, a fim de verificar os métodos desenvolvidos na atividade leiteira específica no âmbito da higienização e controle de leite da região supracitada. Conclui-se que há interferência da assistência técnica na rotina da bovinocultura de leite, no processo de qualidade e que novos estudos e projetos devem ser instituídos para o desenvolvimento do setor.
SISTEMATIZAÇÃO DA ASSISTÊNCIA DE ENFERMAGEM PARA PACIENTE SUBMETIDOS A NEUROCIRURGIA E INDICADORES DE CASOS: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Benvindo Éntero , Inácio Martins Cristiano
Published: August 2024

Os pacientes com doenças neurológicas quando submetidos a procedimentos cirúrgicos podem apresentar diversas complicações e evoluir para desfechos negativos, dentre os quais, o óbito. Objetiva-se relatar através da revisão na literatura a assistência de enfermagem a pacientes submetidos a neurocirurgias e demonstrar os indicadores das doenças que mais ocasionam a procedimentos neurocirúrgicos. Revisão integrativa da literatura, com método que reúne e sintetiza o conhecimento produzido por meio da análise dos resultados evidenciados em estudos primários. Para a seleção dos estudos, foram consultadas bases de dados científicas, como PubMed, Google Scholar, BDENF, LILACS e a Scielo. Para a organização dos dados e viabilização da análise, elaborou-se um quadro com a síntese dos estudos selecionados utilizando o programa Microsoft Office Word 2010. Foram encontradas 100 referências de trabalhos em suportes eletrônicos, sendo 40 no Scielo, 10 no PubMed, 40 no Google Acadêmico e 10 no LILACS. A partir disso todas as 100 referências foram reavaliadas diante as perguntas norteadoras “como ocorre a Sistematização de Enfermagem a pacientes submetidos a neurocirurgias?” e “quais são os indicadores de doenças mais prevalentes do sistema nervoso?”. Destas, excluíram-se aquelas que não cumpriam todos os critérios estabelecidos: ano de publicação dos últimos dez anos e língua portuguesa, inglesa e espanhol. Após isso foram selecionados cinco estudos. Dessarte, pode-se observar, que as doenças de aneurismas cerebrais, tumores cerebrais, lesões cerebrais, doenças neurodegenerativas, hematoma cerebral, epilepsia e enxaqueca que são mais prevalentes para o procedimento de neurocirurgia. Construiu-se um quadro com os principais achados referentes a assistência de enfermagem ao paciente em pós-operatório imediato neurocirurgia. Conclui-se que a aplicação da SAE possibilita ao enfermeiro realizar o planejamento e o atendimento de forma integral, holística e individualizada, evitando possíveis intercorrências e cancelamentos inesperados do procedimento, colaborando para uma melhor qualidade de vida.
ANÁLISE DOS TCCS DEFENDIDOS NO DEPARTAMENTO DE EDUCAÇÃO FÍSICA DA UNIVERSIDADE ESTADUAL DE MARINGÁ SOBRE NATAÇÃO
Authors: Martins Vitória Alice Okuhara , Rojo Jeferson Roberto
Published: August 2024

O presente estudo teve como objetivo analisar a produção científica em formato de Trabalho de Conclusão de Curso (TCC) realizada no Departamento de Educação Física da Universidade Estadual de Maringá (DEF/UEM). Para isso, foram utilizados os arquivos de TCCs disponíveis no site do DEF/UEM, totalizando 71 trabalhos que tinham a natação como tema de estudo dentre os 1967 TCCs produzidos no departamento de 1993 a 2021. Os resultados indicaram que no DEF/UEM há uma predominância de estudos sobre natação com uma perspectiva biodinâmica, sendo as temáticas de motivação e reabilitação são as mais recorrentes. Este cenário revelado nas pesquisas sobre TCCs do DEF/UEM aponta para a necessidade de renovação do quadro de professores especialistas em natação, uma vez que os orientadores que mais se destacaram no estudo já não fazem parte do corpo docente.
Comparative Study: Analysis of the Implementation of Sustainable Distribution of Funds for Sharia Banks and Conventional Banks in Indonesia
Authors: Nihayah Ana Zahrotun , Rifqi Lathif Hanafir
Published: August 2024

Purpose - This research aims to identify the application of sustainable finance in sharia banks and conventional banks and identify obstacles in the application of sustainable finance.Method - The method used in this research is qualitative with a descriptive design. The type of descriptive design method used is a comparative study.Result - The research results show that the implementation of sustainable finance as represented by the allocation of financing at conventional banks (BRI) reached 65.5%, higher than sharia banks (BSI) which only reached 26.95%. the establishment of rules and regulations that are not yet comprehensive in the financial sector, low financial inclusion, low sustainable finance literacy, lack of common perception in financial institutions, the difficulty of balancing economic, social and environmental aspects and low market potential in lending to environmentally sound companies.    Implication - This research was conducted to provide an explanation of the implementation of sustainable distribution of funds in Sharia banks and conventional banks and its challenges.  Originality - Several previous studies have discussed sustainable finance in banking. However, there are still few discussing the comparison of the implementation of sustainable finance and the risks involved.
The Concept of Corporate Social Responsibility in Islamic Banking from the Perspective of Islamic Economics
Authors: Najachah Elysa
Published: August 2024

Purpose - This paper aims to give an alternative to the CSR concept in Sharia banking is appropriate to rule in economy Islam.Method - This paper uses qualitative study through understanding in a way inductive. The approach used is through approach related to normative theology CSR concept in the economy of Islam.Result - CSR in Sharia banking is implemented following the rule economy Islam that is with aqad that complies with Sharia, is legal, and is also transparent in CSR disclosure. Besides that, the CRS concept in Sharia banking can also be used to guard faith, soul, offspring, protecting the mind, and wealth through connection with Allah (hablum min Allah) and also relationships with humans ( hablum Minannas ). As a consequence of the implementation draft, the threat boycott can avoided. This CSR concept is also a form of commitment to Islamic banking to contribute to the field economy, quality communication, and quality of life legally and ethically.Implication - Results study This shows that the concept of CSR in Sharia banking is appropriate with rule economy Islam can contribute to improvement investment, image positive, and loyalty of customers and employees in Syariah banking.Originality - throughout knowledge author, research This is the first study to discuss in a way detailed and systematic related CSR concept in Islamic banking perspective economy Islam.
Pengaruh Good Corporate Governance terhadap Harga Saham Perusahaan Manufaktur Periode 2017-2022
Authors: Arifin Adhyasta Izhar Resvara , Rosidi Rosidi
Published: August 2024

This study aims to investigate the influence of several proxies of Good Corporate Governance (GCG), namely Foreign Ownership, Institutional Ownership, Board of Commissioners, and Audit Committee, on the stock prices of manufacturing sector companies. The research sample consists of 45 manufacturing sector companies listed on the Indonesia Stock Exchange (IDX) during the period 2017-2022. The sampling technique used is purposive sampling, and the final sample obtained is 45 companies. The analysis method employed in this study is multiple linear regression analysis conducted using IBM SPSS 25 software. The results of the study indicate that Institutional Ownership and the Board of Commissioners have a positive influence on the company's stock price. This suggests that the larger the institutional ownership and the more effective the function of the board of commissioners, the more likely the stock price will increase. Conversely, the study found that Foreign Ownership and the Audit Committee do not have a significant impact on stock prices. This means that even if a company has high foreign ownership or an active audit committee, these factors do not directly affect the fluctuations in the company's stock price.
 

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Pengaruh Financial Distress, Audit Lag, Prior Audit Opinion, dan Firm Size terhadap Penerimaan Opini Audit Going Concern
Authors: Fachriyah Nurul , Wulandari Putu Prima
Published: August 2024

Opini audit going concern merupakan hasil evaluasi auditor terhadap asumsi kelangsungan hidup perusahaan berdasarkan pelaporan keuangan. Penelitian ini merupakan penelitian kuantitatif yang dilakukan untuk menguji secara empiris pengaruh financial distress, audit lag, prior audit opinion, dan firm size terhadap penerimaan opini audit going concern berdasarkan agency theory pada perusahaan sektor infrastruktur yang terdaftar di Bursa Efek Indonesia (BEI) dengan periode pengamatan empat tahun, yaitu 2019-2022. Jenis data merupakan data sekunder yang diperoleh dari laporan keuangan tahunan yang diterbitkan oleh website resmi Bursa Efek Indonesia (www.idx.co.id) dan website masing-masing perusahaan. Sampel yang digunakan sebanyak 192 sampel dari 48 perusahaan yang ditentukan melalui metode purposive sampling. Analisis data dilakukan menggunakan analisis statistik deskriptif dan analisis regresi logistik dengan software SPSS versi 26 dan Microsoft Excel 2019. Hasil penelitian menggunakan uji hipotesis menunjukkan bahwa variabel audit lag dan prior audit opinion berpengaruh secara positif terhadap penerimaan opini audit going concern, sedangkan dua variabel lainnya, financial distress dan firm size tidak berpengaruh terhadap penerimaan opini audit going concern.
‘They're telling us it's safe, but how do we know it's safe?’ Different stakeholder perspectives on drinking water safety
Authors: Anderson Heather K. , Quilliam Richard , Price Heather
Published: August 2024

Current definitions of ‘safe’ drinking water and their inclusion in metrics for monitoring progress towards SDG 6.1 (universal access to safe drinking water) are inadequate as they fail to account for the way safety is understood and enacted in people's day-to-day lives. The aim of this study was to characterise the factors that influence what people understand by ‘safe’ drinking water and to identify opportunities to account for non-scientific/alternative ways of understanding ‘safety’ in the provision of drinking water. We used a case study from Scotland where residents have challenged water professionals over the safety of their drinking water. Semi-structured interviews (n = 30) were conducted with people involved in this case, and each participant was asked to draw ‘safe drinking water’. Although many differences between the stakeholders were identified, the drawing exercise revealed that the residents and water professionals alike believed that consumer satisfaction was vital for believing it was safe. Overall, we found that different knowledge, priorities and epistemologies contributed to different perspectives on drinking water safety. In the future, we propose that more transdisciplinary and citizen-centric ways of working are adopted to improve outcomes in the pursuit of SDG 6.1.
Modeling of thermoconvection in a microtube under point heating: computational grid preparation and choice of method
Authors:   Ufa University of Science and Technology, Ufa, Russia, Islamov A.I. , Nabiullina K.R.
Published: August 2024

This paper presents the results of the preparatory stage of modeling the process of thermal convection in microtubes. The finite-volume mesh for a cone-shaped microtube for use within the OpenFOAM software package has been constructed. The obtained mesh was analyzed and tested. An important stage of this work is the analysis of built-in solvers from the OpenFOAM software package, as well as the selection of the optimal solver for solving this particular problem. The advantages and disadvantages of two standard solvers — buoyantBoussinesqPimpleFoam and buoyantPimpleFoam - are considered. It is shown that buoyantBoussinesqPimpleFoam is sufficient for the considered problem, provided that the program is executed using computations based on OpenMPI libraries, which allows to significantly reduce the time of computational experiments. Thus, according to the results of the conducted research, a three-dimensional model of the microtube was prepared, its testing was carried out and the built-in solver from the OpenFOAM software package was selected. The use of the obtained results can have a significant impact on further research in the field of temperature convection in microtubes, and consequently in the processes of optimization of PCR.
Çocuklarda D vitamini ile migren arasındaki ilişkinin değerlendirilmesi
Authors: Kılıç Fedli Emre , İpek Rojan
Published: August 2024

Amaç: Migrende inflamasyon önemli bir rol oynar, bu nedenle vitamin D’nin anti-enflamatuar rolü migren baş ağrılarını önlemede önemli bir rol oynayabilir. Çocuklarda vitamin D eksikliği ile migren arasında bir ilişki olabileceğini düşünüp bu çalışmada bunu göstermeyi amaçladık.

Yöntemler: Bu retrospektif çalışmada, kliniğe migren şikayetiyle başvuran çocuklarla genel muayeneyle başvuran çocuklar karşılaştırıldı. Çocukların hasta dosyalarından alınan demografik verileri, vitamin D düzeyleri, kalsiyum, fosfor, alkalen fosfataz ve albümin değerleri kaydedildi.

Bulgular: Çalışmaya 80’i migren olmak üzere 182 vaka dâhil edildi. Migren grubunun %66,3’ü, kontrol grubunun %67,6’sı kız idi. Hastaların vitamin D düzeylerinin düşük ve normal olarak 2 gruba ayrıldığında migren grubunda %86,3’ü düşük iken, kontrol grubunda %11,8’i düşük olup istatistiksel olarak anlamlı fark saptandı (p
El llamado a la santidad en la formación de los futuros presbíteros diocesanos desde el contexto de la sinodalidad y la propuesta formativa del Beato Manuel Domingo y Sol
Authors: Zottola Ariel , Toro Iván
Published: August 2024

En el presente artículo se ofrecerá la investigación realizada acerca del llamado a la santidad en la formación de los futuros presbíteros diocesanos, desde el actual contexto de la sinodalidad y los escritos del Beato Manuel Domingo y Sol, proponiendo que la temática sea asumida como parte del estilo formativo de la Hermandad de Sacerdotes Operarios Diocesanos. En su desarrollo se ofrece un diálogo entre los textos de don Manuel con autores contemporáneos, para encontrar pistas concretas para la formación en el contexto actual de la sinodalidad. En primer lugar, se desarrolla el llamado a la santidad en la dinámica del discipulado y, luego, adentrando en la dimensión misionera de la vocación presbiteral y de la santidad, se indican caminos concretos para buscar vivir el llamado a la santidad en el ejercicio del ministerio desde la caridad pastoral, que favorezcan la comunión, la participación y la misión. Finalmente, se ofrecen pistas para vivir el llamado a la santidad en el ejercicio del ministerio parroquial desde la sinodalidad.
Neomorphic IDH Heterodimer Mutants: An Underestimated Point in Cancer Pathogenesis
Authors: V. Dorovatovskaia Olga , Yu. Oliferenko Mikhail , A. Sorokin Anatoly , I. Sobolev Daniil , S. Stupnikova Galina , S. Sobakin Danil , N. Nikolaev Eugene , A. Popov Igor , I. Pekov Stanislav
Published: August 2024

Mutations in an essential metabolic enzyme, isocitrate dehydrogenase (IDH), were found in many cancers. The impact of IDH1 and IDH2 proteoforms mutations can vary and de-pend on the cancer type and other genetic alterations. The wild-type IDH1/2 consists of two identical subunits, but the mutant enzyme is a heterodimer of mutant and wild-type subunits, while the mutant homodimer loses its catalytic activity. Thus, the balance of expression of wild-type and mutant proteoforms directly affects enzyme neomorphic activity, cell metabolic por-trait, and, therefore, cell survival and proliferation rates. Here, we generalize the influence of the presence of IDH mutations and the expression of mutant and wild-type proteoforms for various nosologies to demonstrate the deficiency in knowledge about the mutual distribution of the pro-teoforms in cancer cells. The review is supplemented with a brief description of IDH mutations' role in cell metabolic reprogramming and a summary of methods for IDH mutation detection. Eventually, we highlight the necessity of assessing the expression of wild-type and mutated IDH quantitatively, which can help create and deliver personalized approaches for tumor therapy.
Pharmacokinetic Assessments of Ursolic Loaded-Dendrimer Complex
Authors: Singh Aditya , Ansari Vaseem Ahamad , Ansari Tarique Mahmood , Wasim Rufaida , Akhtar Juber , Maheshwari Shubhrat
Published: August 2024

Background:

This study investigates the application of polyamidoamine (PAMAM)
dendrimers as an innovative drug delivery approach for enhancing the pharmacokinetic profile
of ursolic acid (UA), a pentacyclic triterpenoid with multifaceted therapeutic properties. UA,
sourced from plants like Sanguisorba officinalis and Salvia officinalis, has been extensively
studied for its pharmacological characteristics, including anti-inflammatory, antioxidant, and
anti-diabetic properties, as recognized in Traditional Chinese Medicine (TCM). The clinical
utility of UA is hampered by low bioavailability, which is attributed to its hydrophobic nature.
To address this limitation, we explore the use of PAMAM dendrimers, known for their drug
delivery potential.

Methods:

The UA-PAMAM G0 dendrimers were synthesized with varying molar ratios. Characterization
included size analysis, PDI, and zeta potential determination. FTIR confirmed the
chemical structure. Male SD rats were acclimatized and administered UA control suspension
and UA-G0 dendrimer complex orally. Blood samples were collected for pharmacokinetic
analysis. The study obtained IAEC approval.

Results:

The UA-PAMAM G0 dendrimer complexes exhibited varying sizes based on molar
ratios, with the 2:1 ratio showing significantly smaller dimensions. FTIR confirmed successful
conjugation. In the pharmacokinetic study, the UA-G0 dendrimer complex demonstrated higher
plasma concentrations than UA alone, as indicated by increased Cmax and AUC values. The
results suggest enhanced oral delivery and bioavailability of UA in the dendrimer complex.

Conclusion:

This study demonstrated the successful synthesis of UA-PAMAM G0 dendrimer
complexes with size variations based on molar ratios. The pharmacokinetic analysis revealed
improved plasma concentrations and bioavailability of UA in the dendrimer complex compared
to UA alone. These findings highlight the potential of PAMAM dendrimers for enhancing the
oral delivery of hydrophobic compounds like UA, bridging the gap between traditional herbal
medicine and modern drug delivery strategies. Further research can explore the broader applications
of such dendrimer complexes in drug delivery systems.
Determination of Spermidine and other 10 Biogenic Amines in Radix astragali (Huang qi) by HPLC-DAD with Precolumn Derivatization
Authors: Ni Sun Yan , Yun Ai , Rui Wang Jin , Ying He , Lu Zhang , Bin Tian Bin , Peng Tao Shun , Li Liu Jian , Ning Zhang
Published: August 2024

Background:

Radix astragali (a Tonic-Qi traditional Chinese medicine) can enhance
cellular metabolism and increase the lifespan of cells. Spermidine can markedly extend the lifespan.
On the basis of these considerations, we assumed whether any relationship existed between
the anti-aging activity of Radix astragali and spermidine.

Methods:

In this research, spermidine and 10 other kinds of biogenic amines in Radix astragali
samples were identified and determined using high performance liquid chromatography-diode array
detector (HPLC-DAD) with precolumn derivatization. Biogenic amines were extracted with
hydrochloric acid, purified by n-butyl alcohol-dichloromethane extraction, and reacted with dansyl
chloride for derivatization before HPLC analysis.

Results:

The method had good repeatability and reproducibility for the quantitative determination
of biogenic amines in Radix astragali samples. Putrescine, spermidine, and spermine were detected
in 10 batches of Radix astragali samples. The total biogenic amines concentration was
48.09±2.22 mg/kg. Spermidine (22.84±2.59 mg/kg) was the highest amine in Radix astragali samples,
followed by putrescine and spermine. This is the first report that Radix astragali contains biogenic
amines, especially high content spermidine.

Conclusion:

The high content of spermidine might be the one reason for Radix astragali with Tonic-
Qi and anti-aging effect.
Vibrational Spectrophotometry: A Comprehensive Review on the Diagnosis of Gastric and Liver Cancer
Authors: Chandarana Chandni V. , Mithani Namira T. , Singh Diksha V. , Kikani Utkarsh B.
Published: August 2024

Introduction:

Infrared and Raman spectroscopy have emerged as promising diagnostic
tools for gastric and liver cancer, offering significant advantages over traditional histology and biomarker-
based methods.

Methods:

These spectroscopic techniques provide rapid and highly specific molecular fingerprinting
with minimal sample preparation, enabling real-time diagnosis and preserving samples for further
analysis. The integration of nanoparticles, particularly in surface-enhanced Raman spectroscopy,
enhances the sensitivity and resolution of the method by amplifying signal strengths through
localized surface plasmon resonances. This advancement facilitates the detection of subtle molecular
changes associated with cancer, even at early stages.

Results:

Raman spectroscopy, a non-destructive technique, can differentiate between healthy and
malignant cells, aiding in the diagnosis of various gastric cancer forms, including adenocarcinoma
and gastrointestinal stromal tumors. Similarly, IR spectroscopy provides insights into the chemical
composition of tissues, detecting molecular changes associated with cancer. For liver cancer, including
hepatocellular carcinoma, these spectroscopic methods reveal biochemical alterations, facilitating
early detection and characterization of the disease. This review explores the application
of Raman and IR spectroscopy in diagnosing gastric and liver cancers, emphasizing their potential
to enhance diagnostic accuracy and improve patient outcomes by identifying molecular changes
linked to malignancies.

Conclusion:

Overall, the integration of nanoparticles into spectroscopic techniques holds significant
potential for improving the accuracy, speed, and efficacy of cancer diagnostics.
Sodium Butyrate, A Gut Microbiota Derived Metabolite in Type 2 Diabetes Mellitus and Cardiovascular Disease: A Review
Authors: Sarlak Zeynab , Naderi Narges , Amidi Bardia , Ghorbanzadeh Vajihe
Published: August 2024

Type 2 diabetes is characterized by elevated blood glucose levels, leading to an increased
risk of cardiovascular diseases. Sodium butyrate, the sodium salt of the short-chain fatty
acid butyric acid produced by gut microbiota fermentation, has shown promising effects on
metabolic diseases, including type 2 diabetes and cardiovascular diseases. Sodium butyrate demonstrates
anti-inflammatory, anti-oxidative, and lipid-lowering properties and can improve insulin
sensitivity and reduce hepatic steatosis. In this review, we investigate how sodium butyrate influences
cardiovascular complications of type 2 diabetes, including atherosclerosis (AS), heart failure
(HF), hypertension, and angiogenesis. Moreover, we explore the pathophysiology of cardiovascular
disease in type 2 diabetes, focusing on hyperglycemia, oxidative stress, inflammation, and
genetic factors playing crucial roles. The review suggests that sodium butyrate can be a potential
preventive and therapeutic agent for cardiovascular complications in individuals with type 2 diabetes.
Warfarin Dose Maintenance Associated with CYP2C9*2 (rs1799853) and CYP2C9*3 (rs1057910) Gene Polymorphism in North Coastal Andhra Pradesh
Authors: Rangaraj Sivaraj , Ankani Bala Tripura Sundari
Published: August 2024

Background

Deep Vein Thrombosis (DVT) is a high-risk condition that necessitates the use of oral anticoagulants for treatment. Warfarin, a common anticoagulant, exhibits varying levels of efficacy and toxicity among individuals. The CYP2C9 gene promoter polymorphism significantly influences the dosage requirements, a factor that remains underexplored in the contemporary Indian population.

Objectives

This study aimed to investigate the influence of CYP2C9 gene polymorphisms on warfarin dosage due to pharmacogenetic effects. Specifically, it examined the prevalence of the CYP2C9 polymorphic alleles *2 and *3 and their correlation with warfarin dosage in the South Indian Population (NCAP).

Methods

The study involved 96 warfarin-treated patients to determine the genotype frequency of common CYP2C9 polymorphisms. The genotypes of CYP2C92 and CYP2C93 polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A one-way analysis of variance (ANOVA) was conducted to ascertain dosage variation across genotypes.

Results

The study found that the frequencies of the two variations were 25.5% for CYP2C92 and 40.6% for CYP2C93. Patients with a homozygous wild-type genotype for CYP2C9 (*1/*1) required a daily warfarin dose of 4.07 ± 1.75 mg, significantly higher than the *1/*2, *1/*3 (2.93 ± 2.03 mg, p <0.0001) and *2/*2, *2/*3, and *3/*3 patients (1.54± 1.05 mg, p = 0.002). The study also revealed a distinct allelic frequency of CYP2C9 polymorphisms in the study population compared to other populations.

Conclusion

Given the relatively high prevalence of CYP2C9 polymorphisms in the studied population, practitioners should consider these findings to minimize the risk of bleeding when prescribing warfarin.
Green Synthesis of Nanoparticles for Forensic Applications: A Comprehensive Review on Latent Fingerprint Development
Authors: Sharma Anuj , Sharma Vaibhav , Kumari Poonam , Mavri Badal , Sankhla Mahipal Singh , Awasthi Kumud Kant , Gautam Archana , Sharma Tina , Kumar Rajeev
Published: August 2024

Green nanoparticle synthesis has recently gained popularity due to its sustainability
and environmental friendliness. This technology employs natural resources
such as plants, fungi, bacteria, and algae to produce nanoparticles with beneficial
properties. This study aims to investigate the ecologically friendly production of nanoparticles
and their potential use in forensic investigation. Green nanoparticle synthesis
methods provide several advantages over standard chemical synthesis processes,
including less environmental impact, cheaper costs, and the lack of toxic compounds.
Nanoparticles have been successfully manufactured utilizing a wide range of
plant extracts, including those obtained from medicinal plants. Furthermore, nanoparticles
with enhanced properties have been developed employing microorganisms and
their metabolites. Nanoparticles made with environmentally benign technology have
shown significant promise in the realm of forensic study. These nanoparticles can be
employed in forensic analysis methods such as document authentication, DNA profiling,
and fingerprint identification. They are ideal candidates for boosting the sensitivity
and selectivity of forensic investigations because of their unique physicochemical
properties, which include a large surface area, variable size, and great stability.
Furthermore, to enable specialized detection and imaging of Latent fingerprints (forensic
evidence), green-synthesized nanoparticles can be functionalized with certain
ligands or biomolecules. This paper provides an overview of metal, metal oxide, and
fluorescent green nanoparticle manufacturing and their uses in forensic science as latent
fingerprint development.
DAMPAK FLYPAPER EFFECT TERHADAP KEMISKINAN (STUDI KOMPARASI KOTA DENGAN KABUPATEN)
Authors: Khairy Rahmat Nur , Susilo
Published: August 2024

Flypaper effect it’s a phenomenon, when a region's spending is more reactive to transfer funds than its own regional income. The purpose of this study is to examine and analyze the existence of the flypaper effect that occurs, and to find out whether Regional Expenditure is able to mediate income against poverty. By conducting a comparative study between regencies and cities in East Java Province in 2010-2019, using the Path Coefficient Regression method, it was found that there was no flypaper effect in cities, and there was a flypaper effect in regencies. On the other hand, in both cities and regencies, regional spending mediates income against poverty. However, the effect of PAD on poverty in cities tends to be greater, when compared to districts. Thus, in order to achieve the goal of fiscal decentralization towards self-sufficient local government funding, it is necessary to take steps to minimize the effect of the flypaper effect in the district area.
PENGARUH PROFIL RISIKO TERHADAP VARIABEL FINANCIAL DISTRESS (STUDI KASUS PADA BANK KBMI 1 – 4 SERTA BANK BUMN DAN BUSN PERIODE 2017-2021)
Authors: Mohammad Irham Muqoddam  , Sakti Rachmad Kresna
Published: August 2024

This study aimed to analyze the bank's health assessment instrument through the risk profile of the RBBR component with bankruptcy prediction using the Bankometer model. This study used the category of Banks Based on Core Capital (KBMI) class 1 to 4 for the period 2017 to 2021. The components in this study include several risk profiles of a bank including Loan to Deposit Ratio, Non Performance Loans, BOPO, Return on Assets, Capital Adequacy Ratio and Inflation, while Bankometer is measured using the S-Score. The results of the study stated that the risk profile that significantly affects the research sample is credit risk and liquidity, it can be concluded that the higher the capital determined by the bank in order to continue to gain investor confidence but cannot manage properly, it will only increase the high burden on the bank's risk value.
DEMAND FORECASTING: A CASE STUDY OF THE INDONESIAN TOBACCO INDUSTRY
Authors: Bagaskara Hilman , Fajri ananda Candra
Published: August 2024

The tobacco industry, as one of the major industries in Indonesia, has experienced consistent growth. Despite being burdened by stringent regulations; tobacco products still maintain high demand among consumers. Forecasting serves as a crucial tool for every industry, aiding in decision-making and planning. ARIMA is one of the reliable forecasting methods, yet it remains open for further development. This study aims to compare ARIMA and SARIMAX, which incorporates seasonal aspects and external variables, namely weighted tariffs and affordability, to determine which of these forecasting models is more accurate. Through the execution of the equations, this research has demonstrated that SARIMAX outperforms ARIMA with a lower Mean Absolute Percentage Error (MAPE) score of 7.63 compared to ARIMA's more accurate MAPE score of 10.8. These findings indicate that SARIMAX is more accurate, as evidenced by its lower MAPE score of 7.63.
PENGARUH MOTIVASI, PERSEPSI RISIKO, PENGETAHUAN TERHADAP INVESTASI PADA UMKM MELALUI PLATFORM SECURITIES CROWDFUNDING
Authors: Naldi Gio Alpri , Muljaningsih Sri
Published: August 2024

This study aims to determine the effect of motivational variables, risk perception, knowledge on investment in MSMEs through the sharia securities crowdfunding platform. This study uses a quantitative approach with multiple linear regression analysis method. The sampling method is Non-Probability Sampling with Purposive Sampling Technique, and the number of samples is 30 respondents of sharia securities crowdfunding investors. The results of this study indicate that the variables of motivation, risk perception, knowledge have a simultaneous effect on investors in investing in MSMEs through the SCF Syariah platform. Meanwhile, the Risk Perception variable has a negative and insignificant effect on investors in investing in MSMEs through the SCF Syariah platform.
PENGARUH SUKUK, REKSADANA SYARI’AH DAN INFLASI TERHADAP TINGKAT PEREKONOMIAN INDONESIA PERIODE 2011-2020
Authors: Muttaqien Muhammad Izzia Thoriq
Published: August 2024

This study aims to determine and analyze the effect of sukuk, sharia mutual funds and inflation on Indonesia's economic level for the period 2011-2020. Here the data that the authors take is data on Sukuk, Sharia Mutual Funds, Inflation and Economic Level in 2011-2020 for the quarterly period. This study uses the multiple linear regression method to test the hypothesis with statistical analysis tools in the form of SPSS Version 21 software. Hypothesis testing is carried out after the multiple linear regression model to be used is considered feasible or free from violations of classical assumptions so that the test results can be interpreted correctly. Classical assumption test includes normality test, multicollinearity test, heteroscedasticity test. The results in this study show that sukuk have a significant effect on Indonesia's economic level in 2011-2020 for the quarterly period. Sharia mutual funds have a significant effect on Indonesia's economic level in 2011-2020 quarterly period, Inflation has a significant effect on Indonesia's economic level in 2011-2020 quarterly period.
SISTEM PELAYANAN JUAL BELI ONLINE MELALUI MEKANISME DROPSHIPPING DALAM PERSPEKTIF BISNIS ISLAM
Authors: Ilmi Elbas Bangga Yama , Ashar Khusnul
Published: August 2024

Buying and selling online is a technological development that makes it easier for sellers and buyers to carry out buying and selling activities. Especially for sellers who make it easier to market their products with many buying and selling facilities such as dropshipping. Dropshipping is a way of selling that does not require capital and all packaging and shipping activities are carried out by the supplier. This study aims to determine the online buying and selling service system through the dropshipping and the view of Islamic business on the system. The object of this research is Casco Store Mojokerto using descriptive qualitative method with purposive sampling technique. In collecting data, this study used primary and secondary data with data collection techniques in the form of interviews and documentation. The data obtained were analyzed systematically and checked through triangulation so that it corresponds to the actual situation. This study resulted in the finding that Casco Store uses a dropshipping with direct payment schemes and on-site payments that are allowed in Islam.
ANALISIS PENGARUH VARIABEL MAKROEKONOMI TERHADAP SUKUK KORPORASI DI INDONESIA TAHUN 2014-2021
Authors: Pratama Mohammad Daffa , Pimada Laila Masruro
Published: August 2024

Corporate sukuk is an alternative instrument for companies to obtain financing with a safer level of risk. However, when compared to other Islamic capital market products, the number of corporate sukuk products is the least and has not dominated the Islamic capital market. Good macroeconomic conditions can reflect the investment climate and affect the company's growth sukuk issued by issuers. This study aims to determine the effect of macroeconomic variables, namely economic growth, inflation, and exchange rates on corporate sukuk in Indonesia. This study uses 93 samples of data on economic growth, inflation, and exchange rates taken in the period January 2014-December 2021. This study uses two methods, namely quantitative methods and descriptive analysis methods. The quantitative method used to test this research is to use the model used for vector autoregressive (VAR). However, if the variables used in this study pass the stationary test at first difference and there is cointegration, then the quantitative method of Vector Error Correction Model (VECM) is used. The results of this study indicate that the inflation variable affects corporate sukuk in the short and long term in a negative direction. Meanwhile, the variables of economic growth and exchange rate do not affect corporate sukuk in the short term but affect corporate sukuk in the long term.
ANALISIS PENGARUH DANA PIHAK KETIGA (DPK), NON PERFORMING FINANCING (NPF) DAN CAPITAL ADEQUACY RATIO (CAR) TERHADAP PENYALURAN DANA BANK UMUM SYARIAH
Authors: Kukuh Firmansyah  , Noor Iswan
Published: August 2024

This study aims to analyze how Third Party Funds (DPK), Non-Performing Financing (NPF) and Capital Adequacy Ratio (CAR) affect the distribution of Islamic Commercial Bank funds listed on the Indonesia Stock Exchange for the 2016-2020 period. This study uses a quantitative descriptive method, the sample is 8 companies, and panel data regression analysis was chosen as a way of analyzing the data. Based on the t test, Third Party Funds (TPF), Non Performing Financing (NPF) and Capital Adequacy Ratio (CAR) have a significant effect on the distribution of Syariah Commercial Bank Funds in 2016-2020 partially. The results of the F test show that the variables of Third Party Funds (DPK), Non Performing Financing (NPF) and Capital Adequacy Ratio (CAR) together have a significant effect on the Distribution of Islamic Commercial Bank Funds.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT MASYARAKAT BERWAKAF TUNAI SEPERTI YANG DIJELASKAN TEORI PLANNED BEHAVIOR
Authors: Pamungkas Ryan , Fitianto Bahtiar
Published: August 2024

Income redistribution has become an important issue in Indonesia. In this regard, Islam has several instruments to address the problem; one of which is waqf. This type of endowment has developed much. Along the course of time, cash waqf has been implemented. As this waqf should be highly potential, this research aims to identify people’s intention to make this charity using Theory of Planned Behavior. Here income and service quality were used as the variable, while quantitative analysis and multiple linear regression served as the research method. This study finds that income has a significant effect on people’s intention to make cash waqf and that service quality does not significantly influence the said intention.
PENGARUH PAJAK DAN ZAKAT TERHADAP KONSUMSI DI INDONESIA
Authors: Shitny Dwi Istiasih  , Munawar
Published: August 2024

This study aims to determine whether there is an effect of taxes and zakat on consumption in Indonesia. This study uses secondary Time Series data during the observation period, namely 2001-2020 in quarterly form. Based on the results of the analysis, it can be concluded that the income variable has a significant effect on consumption in Indonesia in the long and short term. Furthermore, the tax variable shows significant results in the long term and has no significant effect in the short term. Meanwhile, the zakat variable does not show an effect on consumption. There are several allegations that the zakat variable is not significant to consumption, namely 1) the neutralization of the total effect of zakat and 2) caused by the small number of zakat collection and distribution. In this study it can be suggested that the government, optimizing the collection of taxes and zakat can be further strengthened. For example, reporting and evaluation on zakat, the importance of integrated reporting is due to the lack of public trust in paying zakat through institutions.
PENGARUH BAGI HASIL LITERASI KEUANGAN DAN KEPERCAYAAN TERHADAP KEPUTUSAN MENGGUNAKAN PRODUK TABUNGAN KOPERASI BMT UGT SIDOGIRI KECAMATAN SUKUN KOTA MALANG
Authors: Zidni Muhammad Tsabat , FITANTO BAHTIAR
Published: August 2024

This study aims to determine whether there is a dependent relationship between the variables of financial literacy, trust and profit sharing on saving decisions. The number of respondents to the study was 100 traders from the Pasar Besar City of Malang, East Java, using a quantitative methodology. According to the results of research that has been done, there is a positive relationship between financial literacy, trust and profit sharing on saving decisions. . Of all the independent variables, those that have the greatest influence start from the trust variable of 0.630, the profit sharing variable of 0.366, and the financial literacy variable of 0.278. Thus this study suggests that the government and Islamic savings and loan cooperatives can increase socialization regarding the benefits of using savings products, as well as improve the quality and distribution of Islamic savings and loan cooperatives so as to increase public trust and interest in saving.
PENGARUH PENDAPATAN, PENGETAHUAN TENTANG AKAD PEMBIAYAAN SYARIAH, DAN PROMOSI BANK SYARIAH TERHADAP KEPUTUSAN MENGGUNAKAN PRODUK PEMBIAYAAN HUNIAN SYARIAH BERBASIS AKAD MURABAHAH
Authors: Amien Muhammad Ibnu , Noor Iswan
Published: August 2024

The purpose of this research are to find out whether the income of teachers and employees of MAN 2 and 3 Pekanbaru City, knowledge of teachers and employees of MAN 2 and 3 Pekanbaru City, and the promotion of Syariah Bank have a significant positive effect on the decision in using Islamic residential financing products based on murabahah contracts. The type of research applied is quantitative research, research data is presented in the form of numbers and performs calculations using statistical methods. The objects in this research are teachers and employees at MAN 2 and 3, totaling 104 samples to represent the 141 population. Based on the results of the research, it can be found that the independentvariables consisting of income, knowledge and promotion have an effect on the decision in using Syariah House Ownership Credit. The independent variable that has the most influence on the decision in using Syariah House Ownership Credit is the knowledge variable. Through this research, it is hoped that consumer can better understand the offers from banks regarding financing services so that it is easier to make decisions on the use of Syariah House Ownership Credit provided by Syariah Bank.
KAJIAN PEMIKIRAN YUSUF QARDHAWI TENTANG PENGENTASAN KEMISKINAN
Authors: Muhammad Amri Robbani  , Muttaqin Aminullah Achmad
Published: August 2024

This study aims to find out Yusuf Qardhawi's thoughts on the concept of poverty alleviation. The researcher used the library research method in examining Yusuf Qardhawi's thoughts on poverty alleviation through a book written by Yusuf Qardhawi entitled Musykilat al Faqri wa Kaifa Alajaha al Islam which was translated by Syafril Halim along with Yusuf Qardhawi's other books and journals as support. The results of this study indicate that the concept of poverty alleviation put forward by Yusuf Qardhawi is based on Islamic teachings that poverty can be overcome by working, family compensation, zakat and non-zakat assistance with a note that the concept of Islamic teachings is fully implemented.
PENGARUH RASIO PROFITABILITAS TERHADAP PERUBAHAN HARGA SAHAM PERUSAHAAN YANG TERDAFTAR DI JII
Authors: Rafli Dilazare Wicaksono  , Kornitasari Yenny
Published: August 2024

Investors before carrying out investment activities need to analyze the company's financial statements in order to see the company's performance and estimate the company's stock price movements with the aim of benefiting from investment activities. This study aims to determine the effect of Return On Asset, Return On Equity, Earning Per Share and Net Profit Margin on changes in stock prices in companies listed on the Jakarta Islamic Index. The population used in this study are companies that have been listed for 4 consecutive years during the 2018-2021 period on the Jakarta Islamic Index. The data used is secondary data by purposive sampling. The data analysis method in this study is a hypothesis. From this study, it was found that Return On Asset partially had a positive and significant effect on stock prices. While Return On Equity, Earning Per Share and Net Profit Margin partially have a negative and insignificant effect on stock prices. So that from this research, the Return On Asset ratio can be used by investors as a reference to see future stock price movements and the Return On Equity, Earning Per Share and Net Profit Margin ratios cannot be used to analyze stock price movements.
PENGARUH HALAL AWARENESS, HARGA, DAN IKLAN TERHADAP KEPUTUSAN PEMBELIAN KOBER MIE SETAN DI SURABAYA
Authors: Az-Zahra Narisa , Ika Khusnia Anggraini
Published: August 2024

Indonesia's Muslim population reaches 86.9% of the total population who in their daily life must carry out consumption. As an Islamic consumer, principles must be implemented in order to achieve blessings, such as consuming products that are guaranteed to be halal. The government has set a target for halal food in Indonesia to be number one in the world by 2023. The current condition is that there are still many products that do not have a halal label, such as Kober Mie Setan, but sellers provide advertisements and the prices are relatively cheap. Therefore, consumers are willing to queue to buy the food because of the unusual naming of the menu. The purpose of this study was to determine the effect of halal awareness, price, and advertising on purchasing desicion at Kober Mie Setan in Surabaya. This research is a quantitative study using the PLS-SEM analysis technique. The results show that halal awareness has no significant effect on purchasing decisions for Kober Mie Setan in Surabaya. Prices and advertising partially have a significant effect on purchasing decisions for Kober Mie Setan in Surabaya