bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1-6 from Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer
Authors: Kim Jae-Young , Welsh Eric A. , Fang Bin , Bai Yun , Kinose Fumi , Eschrich Steven A. , Koomen John M. , Haura Eric B.
Published: April 2023

S1. Relative cell viability after MEK inhibitor selumetinib (AZD6244) and binimetinib (MEK162) treatment in KRAS mutant lung cancer cell lines. S2. Western blotting showing target inhibition of MEK inhibitor-treated SILAC phosphoproteomics sample. S3. Phosphosites identified from A427 and A549 cells. S4. Extracted ion chromatograms, MS1 and MS2 spectra, for select phosphopeptides. S5. EBC1 (A) or H1648 (B) cells were incubated with selumetinib (1 μM, 24 hours), and then endogenous MET was immunoprecipitated. S6. Relative cell viability after treatment with MEK inhibitor alone or in combination with MET or EGFR inhibitor with growth factor ligands (HGF or EGF).
Supplementary figures from Stromal-MDM2 Promotes Lung Cancer Cell Invasion through Tumor–Host Feedback Signaling
Authors: Kamer Iris , Daniel-Meshulam Inbal , Zadok Oranit , Bab-Dinitz Elizabeta , Perry Gili , Feniger-Barish Rotem , Perelman Marina , Barshack Iris , Ben-Nun Alon , Onn Amir , Bar Jair
Published: April 2023

Supplementary Fig. S1: Identification of primary fibroblasts isolated from freshly resected lung tumors (CAFs). Supplementary Fig. S2: Kinetics of MDM2 protein elevation by H1299-CM. Supplementary Fig. S3: Cancer-CMs induce elevation in normal and cancer-associated fibroblasts from lung adenocarcinoma and squamous cell carcinoma. Supplementary Fig. S4: Variable elevation of stromal-MDM2 by cancer-CMs. Supplementary Fig. S5: Cancer-CM's species-specific effect. Supplementary Fig. S6: Lung CAFs induce cancer cells' invasion, which is attenuated by both Rapamycin and by knockdown of MDM2 in CAFs. Supplementary Fig. S7: MDM2-dependent pro-invasion effect is p53-independent. Supplementary Fig. S8: In vivo detected tumors are originated from H1299 epithelial cells.
Supplementary Figures 1 - 5 from Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma
Authors: Mehner Christine , Miller Erin , Khauv Davitte , Nassar Aziza , Oberg Ann L. , Bamlet William R. , Zhang Lizhi , Waldmann Jens , Radisky Evette S. , Crawford Howard C. , Radisky Derek C.
Published: April 2023

PDF file - 883K, Supplemental Figure 1. MMP3 and Rac1b expression are not correlated with collagen and smooth muscle actin in pancreatic adenocarcinoma cells. Supplemental Figure 2. Association of Rac1b subcellular localization with patient prognosis is not dependent upon patient stage or grade. Supplemental Figure 3. Induction of fibrosis and activation of metaplasia in response to MMP3. Supplemental Figure 4. Meta-analysis of datasets showing overlap of response of PaTu8988T to MMP3 with pancreas biosets. Supplemental Figure 5. Nuclear localization of pSMAD2 in response to MMP3.
Supplementary Figure Legends from Tumor Cell–Derived MMP3 Orchestrates Rac1b and Tissue Alterations That Promote Pancreatic Adenocarcinoma
Authors: Mehner Christine , Miller Erin , Khauv Davitte , Nassar Aziza , Oberg Ann L. , Bamlet William R. , Zhang Lizhi , Waldmann Jens , Radisky Evette S. , Crawford Howard C. , Radisky Derek C.
Published: April 2023

PDF file - 50K
Supplementary Figure 3 from Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome
Authors: Poulos Rebecca C. , Thoms Julie A.I. , Shah Anushi , Beck Dominik , Pimanda John E. , Wong Jason W.H.
Published: April 2023

Supplementary Figure 3. Analysis of putative promoter mutations in COLO-829 located using matched and unmatched DNase-seq and ChIP-seq data.
supplemental figure 7 from SGK Kinase Activity in Multiple Myeloma Cells Protects against ER Stress Apoptosis via a SEK-Dependent Mechanism
Authors: Hoang Bao , Shi Yijiang , Frost Patrick J. , Mysore Veena , Bardeleben Carolyne , Lichtenstein Alan
Published: April 2023

Suppl fig 7: A) MM1.S MM cells transfected with empty vector (ev) or wild type SGK (sgk) subsequently treated with 0, 10 or 20 nM Bortezomib for 8 hrs followed by immunoblot assay.; B) MM cells uninfected (par=parental) or infected with shRNA targeting scrambled sequence (scr)or 2 separate shRNA (755 & 756) targeting DR5; C) Apoptosis (% above no treatment control, mean+/-SD, n=3) of the 4 cell lines treated with increasing concentrations of bortezomib
Supplementary Figure 2 from Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome
Authors: Poulos Rebecca C. , Thoms Julie A.I. , Shah Anushi , Beck Dominik , Pimanda John E. , Wong Jason W.H.
Published: April 2023

Supplementary Figure 2. Receiver operating characteristic (ROC) curve for the RegulomeDB, FATHMM-MKL and FunSeq2 scores attributed for a non-coding mutation's likely functional impact.
supplemental figure 5 from SGK Kinase Activity in Multiple Myeloma Cells Protects against ER Stress Apoptosis via a SEK-Dependent Mechanism
Authors: Hoang Bao , Shi Yijiang , Frost Patrick J. , Mysore Veena , Bardeleben Carolyne , Lichtenstein Alan
Published: April 2023

Suppl fig 5: SGK protein stability in 8226 cells treated +/- bortezomib (20nM); Data are Mean+/-SD, n=3.
Supplementary Table 3 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
Authors: Maycotte Paola , Jones Kenneth L. , Goodall Megan L. , Thorburn Jacqueline , Thorburn Andrew
Published: April 2023

Supplementary Table 3. Gene set enrichment analysis (GSEA) for RNA sequencing studies of MCF7 and MDA-MB-468 breast cancer cell lines expressing either a non-silencing (NS) shRNA or an ATG7 (A7) shRNA.
Supplementary Table 2 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
Authors: Maycotte Paola , Jones Kenneth L. , Goodall Megan L. , Thorburn Jacqueline , Thorburn Andrew
Published: April 2023

Supplementary Table 2. Significant genes with Q value < 0.01 in the MDA-MB-468 cell line.
Supplementary Figures 1-3 from Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
Authors: Maycotte Paola , Jones Kenneth L. , Goodall Megan L. , Thorburn Jacqueline , Thorburn Andrew
Published: April 2023

Supplementary Figures 1-3. Supplementary Figure 1. MCF7 and MDA-MB-468 cells were transduced with lentiviruses containing shRNAs for ATG7 or BECN1. Supplementary Figure 2. Principal Component Analysis of RNA sequencing data in autophagy-dependent (MDA-MB-468) and independent (MCF7) breast cancer cell lines. Supplementary Figure 3. Autophagy-regulated IL6 secretion increases mammosphere formation in the MCF7 breast cancer cell line.
Supplementary Figure 1 from VDR Status Arbitrates the Prometastatic Effects of Tumor-Associated Macrophages
Authors: Zhang Yan , Guo Quanjun , Zhang Zhujun , Bai Nan , Liu Ze , Xiong Min , Wei Yuquan , Xiang Rong , Tan Xiaoyue
Published: April 2023

PDF file - 25KB, TNF-alpha inhibits VDR expression and promotes EMT initiated by TGF-beta1 stimulation in MCF7.
Supplementary Table 4 from Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells
Authors: Wali Vikram B. , Haskins Jonathan W. , Gilmore-Hebert Maureen , Platt James T. , Liu Zongzhi , Stern David F.
Published: April 2023

XLSX file - 285KB, Predicted activated pathways by ICD ERBB4 versus VEC.
Supplementary Table 3 from Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells
Authors: Wali Vikram B. , Haskins Jonathan W. , Gilmore-Hebert Maureen , Platt James T. , Liu Zongzhi , Stern David F.
Published: April 2023

XLSX file - 60KB, Predicted activation of Transcriptional regulators.
Supplementary Table 1 from Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells
Authors: Wali Vikram B. , Haskins Jonathan W. , Gilmore-Hebert Maureen , Platt James T. , Liu Zongzhi , Stern David F.
Published: April 2023

XLSX file - 41KB, Gene list altered by FL and ICD ERBB4 by transcriptional prolifing.
Supplementary Figure Legends, Table Legends from Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells
Authors: Wali Vikram B. , Haskins Jonathan W. , Gilmore-Hebert Maureen , Platt James T. , Liu Zongzhi , Stern David F.
Published: April 2023

PDF file - 33KB
Supplmentary Figures S1-6 from ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM
Authors: Liu Xue-Song , Genet Matthew D. , Haines Jenna E. , Mehanna Elie K. , Wu Shaowei , Chen Hung-I Harry , Chen Yidong , Qureshi Abrar A. , Han Jiali , Chen Xiang , Fisher David E. , Pandolfi Pier Paolo , Yuan Zhi-Min
Published: April 2023

Supplemental figures S1-6. Supplementary Figure S1. List of genes in human melanoma 19p13.3 focal deletion region. Supplementary Figure S2. The expression of 19p13.3 genes during the progression of human melanoma from nevus to melanoma based on two independent datasets. Supplementary Figure S3. Identify MCAM by microarray gene set enrichment analysis. Supplementary Figure S4. Expression of Mcam in control and Zbtb7a deleted cells by microarray and real time PCR analysis. Supplementary Figure S5. MCAM copy number variation and prognosis in human melanoma. Supplementary Figure S6. A, luciferase assay was performed to assess the effects of increasing amount of ZBTB7A on the luciferase activity of pGL3-Basic and pGL3-MCAM vector in SK-MEL-28 cells. Data shown are mean {plus minus} s.d. of three experiments. B, expression of FLAG-ZBTB7A protein relative to endogenous ZBTB7A in HeLa cells. C, ChIP and real time PCR to quantify MCAM promoter DNA amount with two additional pairs of primers. Data shown are mean {plus minus} s.d of four experiments. D, sequence alignment between human and mouse MCAM promoter region (-300-+1). Conserved ZBTB7A binding sites in human and mouse MCAM promoter are marked. E, sequence of human MCAM promoter used in PGL3 promoter cloning, and the ZBTB7A binding sites, transcription start site are labeled.
Supplementary Table 1 from Prognostic Potential of DNA Methylation and Transcript Levels of HIF1A and EPAS1 in Colorectal Cancer
Authors: Rawłuszko-Wieczorek Agnieszka Anna , Horbacka Karolina , Krokowicz Piotr , Misztal Matthew , Jagodziński Paweł Piotr
Published: April 2023

PDF file - 64K, 1A. Primer sequences, 1B. Clinicopathological parameters of patients selected for bisulfite sequencing.
Supplementary Figure 1 from Prognostic Potential of DNA Methylation and Transcript Levels of HIF1A and EPAS1 in Colorectal Cancer
Authors: Rawłuszko-Wieczorek Agnieszka Anna , Horbacka Karolina , Krokowicz Piotr , Misztal Matthew , Jagodziński Paweł Piotr
Published: April 2023

PDF file - 63K, Kaplan-Meier survival analysis among patients with CRC according to EPAS1 mRNA level and DNA methylation of EPAS1 promoter.
Supplementary Figure Legend from A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis
Authors: Joshi Shweta , Singh Alok R. , Zulcic Muamera , Durden Donald L.
Published: April 2023

Supplementary Figure Legend from A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis
Supplementary Figure 5 from Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis
Authors: Park Jun Won , Jang Seok Hoon , Park Dong Min , Lim Na Jung , Deng Chuxia , Kim Dae Yong , Green Jeffrey E. , Kim Hark Kyun
Published: April 2023

PDF - 249K, Immunohistochemistry for the tumor center and invasive front of gastric cancers.
Supplementary Figure 2 from Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis
Authors: Park Jun Won , Jang Seok Hoon , Park Dong Min , Lim Na Jung , Deng Chuxia , Kim Dae Yong , Green Jeffrey E. , Kim Hark Kyun
Published: April 2023

PDF - 100K, Immunofluorescence and immunohistochemistry for the confirmation of loss of Smad4 and p53.
Supplemental Table 1 from Notch Signaling Activation Is Associated with Patient Mortality and Increased FGF1-Mediated Invasion in Squamous Cell Carcinoma of the Oral Cavity
Authors: Weaver Alice N. , Burch M. Benjamin , Cooper Tiffiny S. , Della Manna Deborah L. , Wei Shi , Ojesina Akinyemi I. , Rosenthal Eben L. , Yang Eddy S.
Published: April 2023

Difference in Notch gene expression by mortality status in UAB and TCGA OSCC samples.
Supplemental Figure 5 from EMT Transition Alters Interstitial Fluid Flow–Induced Signaling in ERBB2-Positive Breast Cancer Cells
Authors: Tchafa Alimatou M. , Ta Mi , Reginato Mauricio J. , Shieh Adrian C.
Published: April 2023

Supplemental Figure 5: Microarray validation.
Supplemental Figure 2 from The YAP-Interacting Phosphatase SHP2 Can Regulate Transcriptional Coactivity and Modulate Sensitivity to Chemotherapy in Cholangiocarcinoma
Authors: Buckarma EeeLN H. , Werneburg Nathan W. , Conboy Caitlin B. , Kabashima Ayano , O'Brien Daniel R. , Wang Chen , Rizvi Sumera , Smoot Rory L.
Published: April 2023

SHP2 inhibition by NSC also shifts YAP from a cytoplasmic to nuclear compartment in a non-CCA cell line.
Supplemental Figure 1 from The YAP-Interacting Phosphatase SHP2 Can Regulate Transcriptional Coactivity and Modulate Sensitivity to Chemotherapy in Cholangiocarcinoma
Authors: Buckarma EeeLN H. , Werneburg Nathan W. , Conboy Caitlin B. , Kabashima Ayano , O'Brien Daniel R. , Wang Chen , Rizvi Sumera , Smoot Rory L.
Published: April 2023

SHP1 does not appear to regulate pYAPY357 levels
Supplemental Materials and Methods from Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer
Authors: Vickman Renee E. , Crist Scott A. , Kerian Kevin , Eberlin Livia , Cooks R. Graham , Burcham Grant N. , Buhman Kimberly K. , Hu Chang-Deng , Mesecar Andrew D. , Cheng Liang , Ratliff Timothy L.
Published: April 2023

Additional information for Materials and Methods section.
Supplemental Information from BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer
Authors: Asangani Irfan A. , Wilder-Romans Kari , Dommeti Vijaya L. , Krishnamurthy Pranathi M. , Apel Ingrid J. , Escara-Wilke June , Plymate Stephen R. , Navone Nora M. , Wang Shaomeng , Feng Felix Y. , Chinnaiyan Arul M.
Published: April 2023

Supplemental Materials and Methods
Supplemental Figure 3 from BET Bromodomain Inhibitors Enhance Efficacy and Disrupt Resistance to AR Antagonists in the Treatment of Prostate Cancer
Authors: Asangani Irfan A. , Wilder-Romans Kari , Dommeti Vijaya L. , Krishnamurthy Pranathi M. , Apel Ingrid J. , Escara-Wilke June , Plymate Stephen R. , Navone Nora M. , Wang Shaomeng , Feng Felix Y. , Chinnaiyan Arul M.
Published: April 2023

De-recruitment of BRD2/3/4 from the SRSF1 and U2AF1 promoter by JQ1.
Supplementary Figure 3 from COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation
Authors: Majumder Mousumi , Landman Erin , Liu Ling , Hess David , Lala Peeyush K.
Published: April 2023

Supplementary Figure 3. Morphology of MCF7 cells before and after miRNA overexpression
Supplemental Methods, Tables S1-2, Table Legends and Figure Legends from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Authors: Javaid Sarah , Zhang Jianmin , Smolen Gromoslaw A. , Yu Min , Wittner Ben S. , Singh Anurag , Arora Kshitij S. , Madden Marissa W. , Desai Rushil , Zubrowski Matthew J. , Schott Benjamin J. , Ting David T. , Stott Shannon L. , Toner Mehmet , Maheswaran Shyamala , Shioda Toshi , Ramaswamy Sridhar , Haber Daniel A.
Published: April 2023

Supplemental Methods, Tables S1-2, Table Legends and Figure Legends Table S1.List of qRT-PCR primers used for epithelial, mesenchymal, inducer and housekeeping genes. Table S2. RNA-ISH quantitation of expression scores used in Figure 5.
Figure S4 from ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma
Authors: Ryan Meagan B. , Finn Alexander J. , Pedone Katherine H. , Thomas Nancy E. , Der Channing J. , Cox Adrienne D.
Published: April 2023

Loss of PREX1 does not alter ERK phosphorylation in melanoma cell lines
Figure S3 from ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma
Authors: Ryan Meagan B. , Finn Alexander J. , Pedone Katherine H. , Thomas Nancy E. , Der Channing J. , Cox Adrienne D.
Published: April 2023

PREX1 transcriptional and post-transcriptional regulation in additional melanoma cell lines
Figure S4 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Authors: Javaid Sarah , Zhang Jianmin , Smolen Gromoslaw A. , Yu Min , Wittner Ben S. , Singh Anurag , Arora Kshitij S. , Madden Marissa W. , Desai Rushil , Zubrowski Matthew J. , Schott Benjamin J. , Ting David T. , Stott Shannon L. , Toner Mehmet , Maheswaran Shyamala , Shioda Toshi , Ramaswamy Sridhar , Haber Daniel A.
Published: April 2023

Figure S4. Heat map analysis of the kinome screen generated by the Wilcoxon method.
Figure S1 from MAPK7 Regulates EMT Features and Modulates the Generation of CTCs
Authors: Javaid Sarah , Zhang Jianmin , Smolen Gromoslaw A. , Yu Min , Wittner Ben S. , Singh Anurag , Arora Kshitij S. , Madden Marissa W. , Desai Rushil , Zubrowski Matthew J. , Schott Benjamin J. , Ting David T. , Stott Shannon L. , Toner Mehmet , Maheswaran Shyamala , Shioda Toshi , Ramaswamy Sridhar , Haber Daniel A.
Published: April 2023

Figure S1. Summary of kinome screen.
Supplementary Table S3 from AMPK-Independent LKB1 Activity Is Required for Efficient Epithelial Ovarian Cancer Metastasis
Authors: Buensuceso Adrian , Ramos-Valdes Yudith , DiMattia Gabriel E. , Shepherd Trevor G.
Published: April 2023

Immunohistochemical scoring of cleaved caspase 3 in EOC xenografts
Figure S7 from Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes
Authors: van der Watt Pauline J. , Roden Laura C. , Davis Kate T. , Parker M. Iqbal , Leaner Virna D.
Published: April 2023

Real-time bioluminescence monitoring showing PER2-dLUC activity in unsynchronised HeLa (A) and WHCO5 (B) cells over time. Bioluminescence readings were obtained using an IVIS Lumina II (PerkinElmer).
Supplementary Figure 2 from TGFβ and Hippo Pathways Cooperate to Enhance Sarcomagenesis and Metastasis through the Hyaluronan-Mediated Motility Receptor (HMMR)
Authors: Ye Shuai , Liu Ying , Fuller Ashley M. , Katti Rohan , Ciotti Gabrielle E. , Chor Susan , Alam Md. Zahidul , Devalaraja Samir , Lorent Kristin , Weber Kristy , Haldar Malay , Pack Michael A. , Eisinger-Mathason T.S. Karin
Published: April 2023

S2. Colon carcinomas are insensitive to TGFB inhibition relative to sarcomas
Supplementary Data from TGFβ and Hippo Pathways Cooperate to Enhance Sarcomagenesis and Metastasis through the Hyaluronan-Mediated Motility Receptor (HMMR)
Authors: Ye Shuai , Liu Ying , Fuller Ashley M. , Katti Rohan , Ciotti Gabrielle E. , Chor Susan , Alam Md. Zahidul , Devalaraja Samir , Lorent Kristin , Weber Kristy , Haldar Malay , Pack Michael A. , Eisinger-Mathason T.S. Karin
Published: April 2023

Supplementary Figure Legends 1-7
Supplemental Figures S1-5 from Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells
Authors: Carrillo Alexia M. , Hicks Mellissa , Khabele Dineo , Eischen Christine M.
Published: April 2023

Supplemental Figures S1-5. Figure S1. Nutlin inhibits γH2AX foci formation and prolongs resolution. Figure S2. Inhibition of pS/TQ foci formation and resolution by Nutlin. Figure S3. Nutlin inhibits γH2AX foci formation and resolution in ovarian cancer cells. Figure S4. Nutlin cooperates with genotoxic agents in p53-inactivated ovarian cancer cells. Figure S5. Nutlin and DNA damaging drugs combine to kill ovarian cancer cells that harbor mutant p53.
Supplementary Table 2 from Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression
Authors: Zhang Yanhong , Feng Xiuli , Zhang Jin , Chen Xinbin
Published: April 2023

The primers used for genotyping mouse strains and cell lines
Supplementary Figure 2 from Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Authors: Cheasley Dane , Pereira Lloyd , Sampurno Shienny , Sieber Oliver , Jorissen Robert , Xu Huiling , Germann Markus , Yuqian Yan , Ramsay Robert G. , Malaterre Jordane
Published: April 2023

Supplementary Figure 2. Myb, TCF-4, and E2F-1 binding sites identified within the human CCNE1 promoter region.
Table S5 from NRF2-Driven KEAP1 Transcription in Human Lung Cancer
Authors: Tian Yijun , Liu Qian , Yu Shengnan , Chu Qian , Chen Yuan , Wu Kongming , Wang Liang
Published: April 2023

"Above the line" analysis summary
Table S4 from NRF2-Driven KEAP1 Transcription in Human Lung Cancer
Authors: Tian Yijun , Liu Qian , Yu Shengnan , Chu Qian , Chen Yuan , Wu Kongming , Wang Liang
Published: April 2023

Publicly available NSCLC datasets used in this research
Supplementary Figure 1 from The Chemokine (CCL2–CCR2) Signaling Axis Mediates Perineural Invasion
Authors: He Shizhi , He Shuangba , Chen Chun-Hao , Deborde Sylvie , Bakst Richard L. , Chernichenko Natalya , McNamara William F. , Lee Sei Young , Barajas Fernando , Yu Zhenkun , Al-Ahmadie Hikmat A. , Wong Richard J.
Published: April 2023

Densitometry analysis of the six chemokine array signals identified in Figure 1A was performed and normalized to the average intensity of 3 controls.
Supplementary Data from A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer
Authors: Lu Chao , Ren Chune , Yang Tingting , Sun Yonghong , Qiao Pengyun , Wang Dan , Lv Shijun , Yu Zhenhai
Published: April 2023

Supplementary Figure 1. Validation of the expression of FBP1 and Notch1in breast cancer cells Supplementary Figure 2. TCGA validates the association between FBP1/Notch1in human clinical samples of breast cancer;Table S1-The novel binding partners of FBP1.
Supplementary Figure 1 from mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress
Authors: Tenkerian Clara , Krishnamoorthy Jothilatha , Mounir Zineb , Kazimierczak Urszula , Khoutorsky Arkady , Staschke Kirk A. , Kristof Arnold S. , Wang Shuo , Hatzoglou Maria , Koromilas Antonis E.
Published: April 2023

Supplementary Fig.1 (A) Quality control of PERK T799 phosphospecific antibody. (B) Quality control of LLY-71 (clone 1-6) rabbit monoclonal antibody to human PERK phosphorylated at T982.
Supplementary Materials from PTK6 Potentiates Gemcitabine-Induced Apoptosis by Prolonging S-phase and Enhancing DNA Damage in Pancreatic Cancer
Authors: Ono Hiroaki , Basson Marc D. , Ito Hiromichi
Published: April 2023

Supplementary Materials. Figure legends for Supplementary Figures
Supplementary Figure Legends from Targeting Nodal in Conjunction with Dacarbazine Induces Synergistic Anticancer Effects in Metastatic Melanoma
Authors: Hardy Katharine M. , Strizzi Luigi , Margaryan Naira V. , Gupta Kanika , Murphy George F. , Scolyer Richard A. , Hendrix Mary J.C.
Published: April 2023

Figure legends for supplementary figures 1-5
Supplementary Figure 4 from miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair
Authors: Czochor Jennifer R. , Sulkowski Parker , Glazer Peter M.
Published: April 2023

NHEJ activity is unchanged upon FOXO3a knockdown in AV16.
Supplementary Figure 3 from miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair
Authors: Czochor Jennifer R. , Sulkowski Parker , Glazer Peter M.
Published: April 2023

Confirmation of polymerase delta mRNA down-regulation.
Supplementary Data from NR4A2 Promotes DNA Double-strand Break Repair Upon Exposure to UVR
Authors: Yin Kelvin , Chhabra Yash , Tropée Romain , Lim Yi Chieh , Fane Mitchell , Dray Eloise , Sturm Richard A. , Smith Aaron G.
Published: April 2023

Supplementary Fig. S1. Nuclear foci characterisation of wild-type and mutant NR4A2 isoforms in mock and UVB conditions. Supplementary Fig. S2. NR4A2 expression protects cells after UVB radiation. A2058 and HT144 cells stably expressing Empty, NR4A2WT, NR4A2Î"NT, NR4A2S337A or NR4A2Î"H12 were exposed to 50mJ/cm2 UVB or mock and viability determined by; (A) MTT assay 24 hours post-UVB treatment. Supplementary Fig. S3. NR4A2 expression alters 53BP1 foci kinetics after UVB radiation. Supplementary Fig. S4. NR4A2 expression alters 53BP1 foci kinetics after UVB radiation. Supplementary Fig. S5. NR4A2 expression alters 53BP1 foci kinetics after IR. (A) A2058 cells stably expressing Empty, NR4A2WT, NR4A2Î"NT, NR4A2S337A or NR4A2Î"H12 proteins were exposed to 5Gy IR, pre-nuclear extracted and fixed at 30 mins or 1 hour post-irradiation.
Supplementary Table S2 from Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1
Authors: Xiao Man , Guo Jianfeng , Xie Lisha , Yang Chun , Gong Lanqing , Wang Zehua , Cai Jing
Published: April 2023

Supplementary Table S2 shows the association between different parameters and the PFS, OS and chemotherapy response in ovarian cancer patients.
Supplementary Table S1 from Let-7e Suppresses DNA Damage Repair and Sensitizes Ovarian Cancer to Cisplatin through Targeting PARP1
Authors: Xiao Man , Guo Jianfeng , Xie Lisha , Yang Chun , Gong Lanqing , Wang Zehua , Cai Jing
Published: April 2023

Supplementary Table S1 shows the association between PARP1 expression and the clinicopathological features in ovarian cancer patients.
Table S5 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Authors: Lin Wenchu , Watanabe Hideo , Peng Shouyong , Francis Joshua M. , Kaplan Nathan , Pedamallu Chandra Sekhar , Ramachandran Aruna , Agoston Agoston , Bass Adam J. , Meyerson Matthew
Published: April 2023

Table S5. Primer list
Table S1 from Dynamic Epigenetic Regulation by Menin During Pancreatic Islet Tumor Formation
Authors: Lin Wenchu , Watanabe Hideo , Peng Shouyong , Francis Joshua M. , Kaplan Nathan , Pedamallu Chandra Sekhar , Ramachandran Aruna , Agoston Agoston , Bass Adam J. , Meyerson Matthew
Published: April 2023

Table S1. H3K4me3 Peaks in RIP-Cre control
Supplemental Information from HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth
Authors: Medler Terry R. , Craig Justin M. , Fiorillo Alyson A. , Feeney Yvonne B. , Harrell J. Chuck , Clevenger Charles V.
Published: April 2023

Supplemental Information text
Supplemental Figures S1 from HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth
Authors: Medler Terry R. , Craig Justin M. , Fiorillo Alyson A. , Feeney Yvonne B. , Harrell J. Chuck , Clevenger Charles V.
Published: April 2023

S1. Specificity of α-ac-K2-HMGN2 antibody. S2. HDAC6 inhibition impairs Stat5a-mediated signaling. S3. Bufexamac and tubacin inhibit the tumorigenic properties of breast cancer cell in vitro. S4. Bufexamac inhibits MDA-MB-231 tumor growth in vivo. S5. Bufexamac treatment impairs the viability of triple-negative WHIM2 PDX cells.
Supplementary Figure 5 from A p53/ARF-Dependent Anticancer Barrier Activates Senescence and Blocks Tumorigenesis without Impacting Apoptosis
Authors: Sinha Vidya C. , Qin Lan , Li Yi
Published: April 2023

Loss of p53 does not diminish DDR following ErbB2 activation.
Supplemental Figure S2 from HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth
Authors: Medler Terry R. , Craig Justin M. , Fiorillo Alyson A. , Feeney Yvonne B. , Harrell J. Chuck , Clevenger Charles V.
Published: April 2023

S2. HDAC6 inhibition impairs Stat5a-mediated signaling.
Supplementary Figure 3 from Autocrine VEGF/VEGFR1 Signaling in a Subpopulation of Cells Associates with Aggressive Osteosarcoma
Authors: Ohba Tetsuro , Cates Justin M.M. , Cole Heather A. , Slosky David A. , Haro Hirotaka , Ando Takashi , Schwartz Herbert S. , Schoenecker Jonathan G.
Published: April 2023

PDF - 1009K, S3. Chemotherapy-naive (Osteosarcoma 2) or adjuvant treated (Osteosarcoma 3-10) human 25 osteosarcoma tissue was stained by immunofluorescence for VEGF (green) or VEGFR1 (red). 26 Merged images (yellow) demonstrate co-expression of VEGFR and VEGFR1 in a subpopulation 27 of human osteosarcoma cells (magnification x200; scale bar, 100microm).
Supplementary Figure 1 from Autocrine VEGF/VEGFR1 Signaling in a Subpopulation of Cells Associates with Aggressive Osteosarcoma
Authors: Ohba Tetsuro , Cates Justin M.M. , Cole Heather A. , Slosky David A. , Haro Hirotaka , Ando Takashi , Schwartz Herbert S. , Schoenecker Jonathan G.
Published: April 2023

PDF - 303K, S1. (A.B) Viability and proliferation of TE85 and 143B cells were measured by MTT (A) and BrdU incorporation assays (B) at baseline and in the presence of increasing concentrations of VEGF165 or VEGFR1 kinase inhibitor over 24 hours. Values are means (plus or minus) SD of the percentage increase compared to baseline from two independent experiments (* P < 0.01 compared to untreated control). (C) Apoptosis of TE85 and 143B cells was assessed by flow cytometry. Cells were treated with 40 μM VEGFR1 kinase inhibitor for 24 hours and then stained with annexin V-FITC/PI. The percentage of annexin V-positive, low-PI staining cells (early apoptosis, green dots) in treated cells was compared to untreated cells. Representative data from two independent experiments are shown. Healthy cells are represented in the lower left quadrant (blue), early apoptotic cells in the lower right quadrant (green), late apoptotic cells in the upper right quadrant (orange), and necrotic cells in the upper left quadrant (red).
Supplementary File 2 - Supplementary figures and table from AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer
Authors: Axelrod Haley D. , Valkenburg Kenneth C. , Amend Sarah R. , Hicks Jessica L. , Parsana Princy , Torga Gonzalo , DeMarzo Angelo M. , Pienta Kenneth J.
Published: April 2023

S1. Generation and characterization of AXL knockout cells. S2. Generation and characterization of AXL overexpression cells. S3. Aggregate characterization. S4. Characterization of bone signal in AXL-on mice at time of death. Supplementary Table 1: Differentially regulated genes in doxycycline-treated Tet-Axl 2 cells compared to Tet-Axl 1.
Figure S4 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner
Authors: Jokić Mladen , Vlašić Ignacija , Rinneburger Miriam , Klümper Niklas , Spiro Judith , Vogel Wenzel , Offermann Anne , Kümpers Christiane , Fritz Christian , Schmitt Anna , Riabinska Arina , Wittersheim Maike , Michels Sebastian , Ozretić Luka , Florin Alexandra , Welcker Daniela , Akyuz Mehmet Deniz , Nowak Michael , Erkel Martin , Wolf Jürgen , Büttner Reinhard , Schumacher Björn , Thomale Jürgen , Persigehl Thorsten , Maintz David , Perner Sven , Reinhardt Hans Christian
Published: April 2023

S4. (a) Representative immunostaining of Pt-(GpG) adducts in KP and KPE cell lines after cisplatin exposure (left). Quantification of Pt-(GpG) adduct staining in KP (n = 5) and KPE (n = 6) cells after cisplatin exposure (right). P values were calculated using two-tailed t-test. (b) Clonogenic survival assay of mock-treated KP and cisplatin-treated KP cells, mock-treated KPE and cisplatin-treated KPE cells, mock-treated KPE post cis and cisplatin-treated KPE post cis cells, mock-treated KPE post cis clone 6 (*6) and cisplatin-treated KPE post cis clone 6 (*6). (c) Detailed representation of Fig. 4c.
Figure S3 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner
Authors: Jokić Mladen , Vlašić Ignacija , Rinneburger Miriam , Klümper Niklas , Spiro Judith , Vogel Wenzel , Offermann Anne , Kümpers Christiane , Fritz Christian , Schmitt Anna , Riabinska Arina , Wittersheim Maike , Michels Sebastian , Ozretić Luka , Florin Alexandra , Welcker Daniela , Akyuz Mehmet Deniz , Nowak Michael , Erkel Martin , Wolf Jürgen , Büttner Reinhard , Schumacher Björn , Thomale Jürgen , Persigehl Thorsten , Maintz David , Perner Sven , Reinhardt Hans Christian
Published: April 2023

S3. Anti-Ercc1 immunostaining of lung sections of KPE mice (n = 8) after cisplatin treatment shown at different magnifications.
Supp. Fig. 1 from SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells
Authors: Handle Florian , Erb Holger H.H. , Luef Birgit , Hoefer Julia , Dietrich Dimo , Parson Walther , Kristiansen Glen , Santer Frédéric R. , Culig Zoran
Published: April 2023

Epigenetic regulation of SOCS3 in cell lines. A, SOCS3 mRNA was measured in AR positive prostate cancer cell lines after treatement with 10 mM 5-Aza-2'deoxycytidine for 72 hours. B, publicly available Bisulfite-Seq. data for the SOCS3 CpG island was analyzed using the UCSC genome browser (hg19) and the ENCODE HAIB Methyl RRBS data track. A region of the SOCS3 promoter that is found to be differentially methylated in cell lines and tissue samples was selected for further methylation specific qPCR analysis.
Figure S3 from Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer
Authors: Mathur Priya S. , Gierut Jessica J. , Guzman Grace , Xie Hui , Xicola Rosa M. , Llor Xavier , Chastkofsky Michael I. , Perekatt Ansu O. , Tyner Angela L.
Published: April 2023

Supplemental Figure: Decreased PTK6 Expression in Tumors in Oncomine Datasets
Supplementary Figure Legends from Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC
Authors: Ohmura Gaku , Tsujikawa Takahiro , Yaguchi Tomonori , Kawamura Naoshi , Mikami Shuji , Sugiyama Juri , Nakamura Kenta , Kobayashi Asuka , Iwata Takashi , Nakano Hiroshi , Shimada Taketoshi , Hisa Yasuo , Kawakami Yutaka
Published: April 2023

Supplementary figure legends
Supplementary Figure 7 from Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC
Authors: Ohmura Gaku , Tsujikawa Takahiro , Yaguchi Tomonori , Kawamura Naoshi , Mikami Shuji , Sugiyama Juri , Nakamura Kenta , Kobayashi Asuka , Iwata Takashi , Nakano Hiroshi , Shimada Taketoshi , Hisa Yasuo , Kawakami Yutaka
Published: April 2023

Detection of focal lymph node metastasis by IHC for Turbo-GFP.
Supplementary Figure 4 from Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC
Authors: Ohmura Gaku , Tsujikawa Takahiro , Yaguchi Tomonori , Kawamura Naoshi , Mikami Shuji , Sugiyama Juri , Nakamura Kenta , Kobayashi Asuka , Iwata Takashi , Nakano Hiroshi , Shimada Taketoshi , Hisa Yasuo , Kawakami Yutaka
Published: April 2023

Representative immunohistochemistry samples for Myo1b and D2-40.
Supplementary Figure 3 from Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC
Authors: Ohmura Gaku , Tsujikawa Takahiro , Yaguchi Tomonori , Kawamura Naoshi , Mikami Shuji , Sugiyama Juri , Nakamura Kenta , Kobayashi Asuka , Iwata Takashi , Nakano Hiroshi , Shimada Taketoshi , Hisa Yasuo , Kawakami Yutaka
Published: April 2023

Significant correlation between Myo1b-ImageJ score and "high and low" classification using Myo1b-IHC score.
Supplementary Figure 3 from KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis
Authors: Ghaleb Amr M. , Elkarim Enas A. , Bialkowska Agnieszka B. , Yang Vincent W.
Published: April 2023

Beta-catenin, Ki67 and cyclin D1 staining in colonic adenomas of Klf4fl/fl/ApcMin/+ and Klf4Î”IS/ApcMin/+ mice.
Supplementary Figure 1 from KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis
Authors: Ghaleb Amr M. , Elkarim Enas A. , Bialkowska Agnieszka B. , Yang Vincent W.
Published: April 2023

Klf4Î”IS/ApcMin/+ mice develop significantly more small intestinal adenomas than Klf4fl/fl/ApcMin/+ mice.
Supplementary Figure Legends from Helicobacter pylori Induces a Novel NF-kB/LIN28A/let-7a/hTERT Axis to Promote Gastric Carcinogenesis
Authors: Shen Li , Zeng Jiping , Ma Lin , Li Shuyan , Chen Chunyan , Jia Jihui , Liang Xiuming
Published: April 2023

Supplementary Figure Legends 1 and 2
Figure S5 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Authors: de Conti Aline , Dreval Kostiantyn , Tryndyak Volodymyr , Orisakwe Orish E. , Ross Sharon A. , Beland Frederick A. , Pogribny Igor P.
Published: April 2023

Gene expression and gene-specific histone H4 lysine 16 acetylation of cell death-related genes in the livers of STAM mice at NASH stage.
Supplemental Table 2 from PRAS40 Phosphorylation Correlates with Insulin-Like Growth Factor-1 Receptor-Induced Resistance to Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells
Authors: Dougherty Michael I. , Lehman Christine E. , Spencer Adam , Mendez Rolando E. , David Abel P. , Taniguchi Linnea E. , Wulfkuhle Julie , Petricoin Emanuel F. , Gioeli Daniel , Jameson Mark J.
Published: April 2023

Supplemental Table 2: The signaling impact of IGF1R activation in sensitive vs. resistant cell lines for all analytes examined by RPPA. RPPA was performed as described in the Methods. For each protein in each cell line, an IGF impact ratio was calculated by dividing the protein level in cells treated with EGFR-TKI plus desIGF1 by the protein level in cells treated with EGFR-TKI alone. For each protein and EGFR-TKI, the average IGF1 impact ratio across all sensitive cell lines was divided by the same average ratio for all resistant cell lines; this ratio represents the relative change in protein level in sensitive vs. resistant cells for a given EGFR-TKI and was rank-ordered to identify the proteins most likely associated with IGF1R-based treatment resistance. Amino acid residues indicate sites of phosphorylation.
Figure S3 from Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
Authors: de Conti Aline , Dreval Kostiantyn , Tryndyak Volodymyr , Orisakwe Orish E. , Ross Sharon A. , Beland Frederick A. , Pogribny Igor P.
Published: April 2023

Histone modifications in the livers of control mice and STAM mice.
Supplementary Table 3 from A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma
Authors: Hiemer Samantha E. , Zhang Liye , Kartha Vinay K. , Packer Trevor S. , Almershed Munirah , Noonan Vikki , Kukuruzinska Maria , Bais Manish V. , Monti Stefano , Varelas Xaralabos
Published: April 2023

Supplementary Table 3. qPCR primers used in the study.
Supplementary Table S1 from Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer
Authors: Dosch Austin R. , Dai Xizi , Reyzer Michelle L. , Mehra Siddharth , Srinivasan Supriya , Willobee Brent A. , Kwon Deukwoo , Kashikar Nilesh , Caprioli Richard , Merchant Nipun B. , Nagathihalli Nagaraj S.
Published: April 2023

Primary antibodies used for immunohistochemistry and Western blot analysis.
Supplementary Figure Legends from Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer
Authors: Dosch Austin R. , Dai Xizi , Reyzer Michelle L. , Mehra Siddharth , Srinivasan Supriya , Willobee Brent A. , Kwon Deukwoo , Kashikar Nilesh , Caprioli Richard , Merchant Nipun B. , Nagathihalli Nagaraj S.
Published: April 2023

Supplementary Figure Legends (S1-S3)
Supplementary Data from CCR2 Chemokine Receptors Enhance Growth and Cell-Cycle Progression of Breast Cancer Cells through SRC and PKC Activation
Authors: Yao Min , Fang Wei , Smart Curtis , Hu Qingting , Huang Shixia , Alvarez Nehemiah , Fields Patrick , Cheng Nikki
Published: April 2023

Supplementary Figure 1. Molecular characterization of fibroblasts. Supplemental Figure 2. Fibroblasts do not significantly affect metastasis of MCF10CA1d breast tumor xenografts. Supplemental Figure 3. CCR2 knockdown in 4T1 mammary carcinoma cells inhibits fibroblast mediated tumor growth. Supplementary Figure 4. CCL2 not affect AKT, SMAD3 or ERK1/2 phosphorylation in MCF10CA1d breast cancer cells. Supplemental Figure 5. Heatmap analysis of cell growth and cell cycle related proteins in CCR2 deficient breast cancer cells.
Supplementary figure 1 from IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling
Authors: Wang Yong Antican , Sun Yunguang , Palmer Joshua , Solomides Charalambos , Huang Li-Ching , Shyr Yu , Dicker Adam P. , Lu Bo
Published: April 2023

Supplementary figure 1 with 4 panels of images
Table S2 from Tumor Progression Is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis
Authors: Morita Tsuyoshi , Hayashi Ken'ichiro
Published: April 2023

Table S2 shows the raw data of microarray analysis.
Supplemental Figure 2 from Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma
Authors: Berry Jesse L. , Xu Liya , Kooi Irsan , Murphree A. Linn , Prabakar Rishvanth K. , Reid Mark , Stachelek Kevin , Le Bao Han A. , Welter Lisa , Reiser Bibiana J. , Chévez-Barrios Patricia , Jubran Rima , Lee Thomas C. , Kim Jonathan W. , Kuhn Peter , Cobrinik David , Hicks James
Published: April 2023

Supplemental Figure 2, online only: Hierarchical clustering matrix based on the genomic instability of the Copy Number Alteration (CNA) profiles of all the AH samples included in this analysis. Samples are listed by Case number_# based on the order of AH sampling (e.g. 1, 2, 3). Samples from eyes that were enucleated are indicated by the red bar adjacent the dentogram, those from eyes that were salvaged are indicated in blue.
Supplementary Figure S3 from The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer
Authors: Ding Mei , Van der Kwast Theodorus H. , Vellanki Ravi N. , Foltz Warren D. , McKee Trevor D. , Sonenberg Nahum , Pandolfi Pier P. , Koritzinsky Marianne , Wouters Bradly G.
Published: April 2023

Immunostaining for phosphorylated eIF4E in the four groups of mice at 10 months and 12 months of age as indicated.
Supplemental Table 1 A from Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer
Authors: Mohammad Amro H. , Kim Sung-Hoon , Bertos Nicholas , El-Assaad Wissal , Nandi Ipshita , Smith Harvey , Yang Jieyi , Chen Owen J. , Gamache Isabelle , Rao Trisha , Gagnon Bruno , Gruosso Tina , Tremblay Michel L. , Sonenberg Nahum , Guiot Marie-Christine , Muller William , Park Morag , Teodoro Jose G.
Published: April 2023

Clinical parameters of patients from whom tissue microarrays were acquired for PRR staining.
Supplemental Figure Legends 1-3 from Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer
Authors: Mohammad Amro H. , Kim Sung-Hoon , Bertos Nicholas , El-Assaad Wissal , Nandi Ipshita , Smith Harvey , Yang Jieyi , Chen Owen J. , Gamache Isabelle , Rao Trisha , Gagnon Bruno , Gruosso Tina , Tremblay Michel L. , Sonenberg Nahum , Guiot Marie-Christine , Muller William , Park Morag , Teodoro Jose G.
Published: April 2023

Figure S1. This figure compares ATP6AP2 expression in normal and tumour human prostate and breast tissues. Figure S2. This figure contains bright-field counterparts of LysoTracker images. This figure also contains HER2 immunostaining after PRR knockdown in SKBR3 cells. Figure S3. This figure contains clinical data that complement the observations made in Figure 4.
Supplemental Table 2 from BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number
Authors: Yoshino Yuki , Qi Huicheng , Fujita Hiroki , Shirota Matsuyuki , Abe Shun , Komiyama Yuhei , Shindo Kazuha , Nakayama Masahiro , Matsuzawa Ayako , Kobayashi Akihiro , Ogoh Honami , Watanabe Toshio , Ishioka Chikashi , Chiba Natsuko
Published: April 2023

OLA1 residues responsible for the biological functions.
Supplementary Tables 1-6 from Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways
Authors: Sarmento-Cabral André , L-López Fernando , Gahete Manuel D. , Castaño Justo P. , Luque Raúl M.
Published: April 2023

Supplemental Table 1. Diete composición information. Supplemental Table 2. Specific set of primers used for the amplification of human and mouse transcripts by qPCR. Supplemental Table 3. Effect of HFD on the tumors gene expression. Supplementary Table 4. Effect of metformina treatment on the tumors gene expression under a LFD. Supplementary Table 5. Effect of metformina treatment on the tumors gene expression under a HFD. Supplementary Table 6. Effect of HFD on the tumors gene expression on both metformin treated groups.
Supplementary Figures 1-6 from Metformin Reduces Prostate Tumor Growth, in a Diet-Dependent Manner, by Modulating Multiple Signaling Pathways
Authors: Sarmento-Cabral André , L-López Fernando , Gahete Manuel D. , Castaño Justo P. , Luque Raúl M.
Published: April 2023

S1. Representative image of the size and anatomo-pathological evaluation of the generated tumors. S2. Relative expression (fold-change) of all the significantly altered genes when comparing HFD- and LFD-fed control groups (HFD-H2O and LFD-H2O respectively). S3. Relative expression (fold-change) of all the significantly altered genes within the apoptosis (A) and cell cycle (B) pathways when comparing both HFD-fed, mice treated with metformin or vehicle (HFD-Met and HFD-H2O). S4. Representative conceptual maps depicting the genes associated to apoptosis (upper panel) and cell cycle (lower panel) pathways whose expression is significantly altered when comparing both HFD-fed groups, treated with metformin or vehicle (HFD-Met with HFD-H2O. S5. Relative expression (fold-change) of all the significantly altered genes within the cell cycle (A) and JAK-STAT (B) pathways when comparing both metformin-treated groups (HFDMet and LFD-Met, respectively). S6. Representative conceptual maps depicting the genes associated to cell cycle (upper panel) and JAK-STAT (lower panel) pathways whose expression is significantly altered when comparing both metformin-treated groups (HFD-Met and LFD-Met, respectively).
Movie S2 from The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer
Authors: Manca Sonia , Frisbie Cole P. , LaGrange Chad A. , Casey Carol A. , Riethoven Jean-Jack M. , Petrosyan Armen
Published: April 2023

3D SIM animation of the LNCaP (c-26) cells after EtOH treatment (35 mM for 96 h) stained with giantin (red).
Movie S1 from The Role of Alcohol-Induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer
Authors: Manca Sonia , Frisbie Cole P. , LaGrange Chad A. , Casey Carol A. , Riethoven Jean-Jack M. , Petrosyan Armen
Published: April 2023

3D SIM animation of the control LNCaP (c-26) cells stained with giantin (red).
Figure S1 from BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number
Authors: Yoshino Yuki , Qi Huicheng , Fujita Hiroki , Shirota Matsuyuki , Abe Shun , Komiyama Yuhei , Shindo Kazuha , Nakayama Masahiro , Matsuzawa Ayako , Kobayashi Akihiro , Ogoh Honami , Watanabe Toshio , Ishioka Chikashi , Chiba Natsuko
Published: April 2023

Expression of HA-OLA1 in breast tissue-derived and non-breast tissue-derived cell lines.
Supplementary Data from Unraveling the Cellular Mechanism of Assembling Cholesterols for Selective Cancer Cell Death
Authors: Wang Huaimin , Feng Zhaoqianqi , Yang Cuihong , Liu Jinjian , Medina Jamie E. , Aghvami S. Ali , Dinulescu Daniela M. , Liu Jianfeng , Fraden Seth , Xu Bing
Published: April 2023

Figure S1. Cell viability of unstimulated A2780 cell line (A and B) or selected A2780 cell line. Figure S2. Cell viability of Kuramochi, OVSAHO, Saos-2, HepG2, and T98G cells treated with pTC-1 for 24, 48 and 72 h. Figure S3. Cell viability of A2780cis or HeLa cells without or with addition of methyladenine (2 or 5 mM) in the presence of pTC-1 for 24, 48 and 72h. Figure S4. CLSM images of PI (red) and FITC-annexin V (green) stained HeLa cells. Scheme S1. Molecular structure of NBD-pTC-1.