bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Wanprestasi Pada Perjanjian Kerjasama Investasi Pembuatan Pabrik Mie Dan Bihun
Authors: Sundari Djolo Puri Lale , Arifin Dilaga Zaenal
Published: February 2023

Tujuan penelitian ini adalah untuk mengetahui dasar pertimbangan hakim dalam memutus perkara wanprestasi pada perjanjian kerja sama Investasi Pembuatan Pabrik Mie Dan Bihun Dalam Putusan Pengadilan Negeri Malang Nomor : 98/Pdt.G/2019/PN Mlg. Metode penelitian hukum yang digunakan adalah metode penelitian hukum normatif. Hasil penelitian menyebutkan bahwa dasar pertimbangan hakim dalam memutus perkara wanprestasi sebagaimana dalam Putusan Pengadilan Negeri Malang Nomor 98/Pdt.G/2019/PN Mlg yaitu berdasarkan dalil-dalil gugatan serta bukti-buktidari pihak penggugat. Akibat hukumnya adalah menyebabkan pihak Tergugat harus membayar kerugian yang diderita penggugat dan membayar biaya perkara.
Penyelesaian Wanprestasi Perjanjian Franchise
Authors: Ali Saputro M. Ramadoni , Jaya Subadi Eka
Published: February 2023

Tujuan penelitian ini untuk mengetahui apakah penyebab wanprestasi yang dilakukan oleh penerima waralaba Tentang Kita Cokelat dan untuk mengetahui penyelesaian wanprestasi penerima waralaba Tentang Kita Cokelat. Metode yang digunakan adalah metode penelitian hukum normatif empiris. Berdasarkan dari hasil penelitian diketahui bahwa perjanjian franchise Tentang Kita Cokelat telah sesuai dengan KUH Perdata, namun dikatakan kurang apabila ditinjau dari Peraturan Pemerintah No. 42 Tahun 2007 tentang Waralaba. Pihak franchisor tidak melaksanakan salah satu kewajibannya, namun untuk akibat hukum apabila tidak dilaksanakan kewajiban oleh para pihak tidak diatur dalam perjanjian, jika timbul kerugian di kemudian hari karena alasan tersebut, maka akan diselesaikan dengan cara musyawarah sesuai dengan isi perjanjian tersebut.
Pelaksanaan Perceraian Dengan Alasan Suami Mafkud
Authors: Rahmianti Rahmianti , Hadi Adha Lalu
Published: February 2023

Tujuan penelitian ini untuk mengetahui pengaturan hukum cerai sebab suami mafkud dalam kompilasi hukum islam (KHI) dan Undang-Undang No. 1 Tahun 1974 tentang Perkawinan, dan hambatan-hambatan bagi hakim dalam memutus perceraian sebab suami mafkud di Pengadilan Agama Selong. Metode penelitian yang digunakan yakni penelitian hukum normatif empiris. Dari hasil penelitian dianalisis bahwa pengaturan hukum sebab suami mafkud dapat dilihat pada ketentuan Pasal 116 bagian kesatu dan Pasal 116 huruf (g). Kompilasi Hukum Islam. Selain itu, pada Pasal 39 Ayat 2 Undang-Undang Nomor 1 Tahun 1974 tentang Perkawinan dan Pasal 19 Peraturan Pemerintah Nomor 9 Tahun 1975 Pasal 19 Peraturan Pemerintah Nomor 9 Tahun 1975 dapat dijadikan dasar istri untuk menggugat cerai suaminya yang mafqud. Hambatan-hambatan bagi hakim dalam memutus perceraian sebab suami Mafkud di Pengadilan Agama Selong dibagi menjadi dua faktor yakni faktor internal dan faktor eksternal. Adapun faktor internal meliputi faktor undang-undang dan faktor sarana dan prasarana. Kemudian faktor eksternal diakibatkan oleh para pihak dan keterangan sanksi yang terkadang berubah-ubah.
Analisis Putusan Mahkamah Agung Nomor 1644 K/Pdt/2020 Atas Perkara Ingkar Janji Menikah Sebagai Dasar Perbuatan Melawan Hukum
Authors: Sugandi Wildan , Fathoni M. Yazid
Published: February 2023

Penilitian ini bertujuan untuk mengetauhi Pengaturan Perjanjian tentang  peminangan menurut KUHPerdata, UU Perkawinan, KHI, Hukum adat dan Ratio Decidendy Putusan Mahkamah Agung Nomor 1644 K/PDT/2020 dalam Perkara Ingkar Janji Menikah Sebagai Dasar Perbuatan Melawan Hukum, serta bentuk perlindungan hukum bagi pihak yang dirugikan. Jenis Penelitian ini adalah penelitian hukum normatif, dengan menggunakan pendekatan perundang-undangan,pendekatan konseptual, dan pendekatan kasus. Hasil penelitian ini menunjukkan bahwa perbuatan pengingkaran janji kawin merupakan perbuatan melawan hukum yang merujuk pada Pasal 1365 KUHPer dalam arti yang luas. Pertimbangan hakim yang digunakan dalam memutus perkara NOMOR 1644 K/PDT/ 2020 merupakan penafsiran melawan hukum dalam arti yang luas, yaitu termasuk perbuatan yang bertentangan dengan norma kesusilaan dan kepatutan dalam masyarakat. Pengingkaran janji kawin yang menimbulkan kerugian materiil dan immaterial sehingga  dalam putusan hakim mewajibkan Tergugat untuk membayar ganti kerugian sebesar Rp 150.000.000 kepada Penggugat akibat pencemaran nama baik yang dilakukannya terhadap Penggugat.
Perjanjian Kerjasama Dan Bagi Hasil Antara Pokdarwis Dengan Pemerintah Desa
Authors: Qiram Zaiyinul , Wagian Diangsa
Published: February 2023

Penelitian ini bertujuan untuk mengetahui dan menjelaskan tentang perjanjian kerjasama dan bagi hasil antara Pokdarwis dengan Pemerintah Desa Bilebante yang di atur berdasarkan Perdes No 3 Tahun 2016 Tentang Pengelolaan Desa Wisata Hijau dalam mengatur Hak dan Kewajiban Kedua belah pihak serta Implementasi di lapangan. Metode penelitian dalam penulisan ini adalah  empiris. Hasil penelitian ini adalah hak dan kewajiban kedua belah pihak sudah di atur dalam Perdes, untuk bagi hasil dari keuntungan sesuai kesepakatan kedua belah pihak. Implementasi yang dilaksanakan dalam Perdes tersebut seperti pemberian alokasi dana, pihak yang berhak mengelola Desa Wisata Hijau, dan bagi hasil kedua belah pihak.
Anxiolytic effects of an aqueous extract of Crassocephalum bauchiense Hutch (Asteraceae) in mice with possible GABAergic involvement
Authors: Cleabert Nwombobue Nkwemeh  , Agathe Fotio Tonfack  , Paul Aimé Noubissi  , Neteydji Sidiki  , Germain Sotoing Taiwe
Published: February 2023

Background and Objective: Crassocephalum bauchiense Hutch is a species of flowering plant from the Asteraceae family. It’s used in traditional medicine for the treatment of brain disorders including epilepsy, depression and anxiety. This study evaluated the anxiolytic effects of Crassocephalum bauchiense aqueous extract and its possible mechanism of action. Materials and Methods: The aqueous extract of Crassocephalum bauchiense (25, 50, 100 and 200 mg/kg) were administered orally to mice one hour before the behavioural testing. Elevated plus maze and open field tests were used, respectively for detecting it anxiolytic properties. Immediately after the open field test, animals were sacrificed and the brain GABA content, and the activities of GAD and GABA-T were measured. Results: Crassocephalum bauchiense (100 and 200 mg/kg) significantly increased the number of entries into, percentage of entries into, and percentage of time in open arms, and reduced rearing, head dipping, and the percentage of time in closed arms, in the elevated plus maze. The plant extract significantly increased crossing and reduced rearing and defecation, in the open field test. In biochemical experiments, the concentration of GABA and the activity of GAD were increased; while the GABA-T activity was decreased, respectively, in the brain of Crassocephalum bauchiense treated-mice. Conclusion: These results suggest that Crassocephalum bauchiense aqueous extract possess anxiolytic properties in the models employed. The extract might potentially act by GABAergic activation in the central nervous system. These data justify and explain the use of Crassocephalum bauchiense to treat anxiety empirically in traditional medicine.
Compare different techniques to retrieve image from database using MATLAB
Authors: Reshu Choudhary
Published: February 2023

Newly World Wide Web technologies, there is need to secure data. For securing data cryptography and other relevant techniques were introduced. Multimedia data stream, traditional textual based encryption schemes are not successful so there is need to develop new encryption schemes. During transmission and storage over a network, multimedia content such as digital images and other information are vulnerable to unauthorized access. The images used may be gray or color scale images. There are many measures for testing image quality, like as the mean structural similarity, and mean absolute error, Mean Square Error (MSE), and Peak Signal-to-Noise Ratio (PSNR). These are computed by averaging the squared intensity differences of distorted and original image pixels, along with the related quantity of the PSNR. Results of experiments show that same size images are efficiently encrypted with reliable maximum PSNR as compared with different size images. MATLAB2013a is used for simulation purpose. As refereed by the simulation results, the proposed system not only shows the efficiency in hiding the attributes but also provides better cover image selection.
Literature review: Improvement patient safety during the pandemic covid-19
Authors: Cicih Wahyu Adiningsih  , Iman Permana
Published: February 2023

Patient safety has been a major challenge for patient safety and healthcare systems over the past 20 years. In 1999 To Err Is Human by the Institute of Medicines raised public awareness about patient safety and described the potential for significant harm to patients. Evidence shows that despite concerted efforts to make health care safer unintentional harm by health care providers that seriously harms patients is still common. A 2016 study estimated that 140.400 deaths were caused by medical error in the United States making medical error the third leading cause of death in the United States and further emphasizing the need for improved patient safety. Healthcare systems around the world continue to take a treatable toll on patients. It is a preventable complication of care that accounts for 3.6% of acute hospital deaths in England. There are financial implications of poor care and negative outcomes. For example the UK Health Foundation says: Careful care is expensive. Unstable production systems; And costs can be reduced by providing reliable care. This review examines the goals of health reform and national efforts to create a culture of quality improvement and patient safety principles. And show how these principles can be applied to patient care and health care practice.
Challenges of parents and their child’s academic performance in modular distance learning
Authors: Ma. Rosola Trillana King
Published: February 2023

The study focuses on the challenges of parents and their child's academic performance in science in modular distance learning. In this descriptive-survey research design, data were gathered from 10 parents of grade four pupils in San Nicolas Elementary School using convenience sampling. Gathered data were systematically treated and analyzed using frequency, percentage count, mean, standard deviation, and Pearson-r correlation. Findings revealed that individual-related challenges such as supervision of child's studies, and poor teaching skills were the most significant challenges parents experienced in implementing modular learning. Parents disagreed that instructional and institutional challenges affect them in modular distance learning. The respondents' children performed satisfactorily in science during the first and second quarters of the school year. There was a moderately significant relationship between individual-related and instructional-related challenges. However, a weak significant relationship is surfaced between parents' institutional-related challenges and their child’s academic performance. No significant difference was observed regarding individualrelated, instructional-related, and institutional-related challenges when grouped according to their profile variables. The researcher concluded that this study on modular distance learning contributed fairly and minimally to students' science performance brought about by continued social and academic adjustment. School and parents' involvement in implementing modular learning is essential for improving the modality.
Study of influence of environmental variables on water quality parameters of Thippayya Lake of Mysore, India
Authors: Suresha N. S  , Smitha N  , Shiva Kumar D
Published: February 2023

In order to distribute and utilize the water resources as effectively as possible, it is crucial to evaluate quality of the water. Knowing the water demand for diverse uses, such as irrigation, industry, public health, and domestic uses, both now and in the future, becomes essential. An evaluation of the water quality of the Thippayya lake has been attempted in the current study. Analysis was done on the physico-chemical characteristics of water samples taken from the Thippayya Lake in four different months, including colour, odour, temperature, electrical conductivity, total hardness, total dissolved solids, alkalinity, calcium, magnesium, chloride, fluoride, phosphate, iron, sulphate, and nitrate, as well as their correlation to water quality. The physico-chemical characteristics of the water sample showed a substantial variation over the course of four months. BOD and COD readings fluctuate more than other parameters do. Alkalinity, turbidity, calcium, and magnesium hardness, DO, BOD, and COD levels in the current study are over the acceptable limit. Controlling the lake's physicochemical parameters may lead to balanced phytoplankton growth and a reduction in eutrophication.
Implementasi Bentuk Kegiatan Pembelajaran Riset
Authors: Ramli Irwan , Nurasia Nurasia , Khaerati Khaerati
Published: February 2023

The purpose of this research is to find out about implementing the form of research learning activities at Cokroaminoto Palopo University. The type of research used is literature study research related to how research learning activities form concerning the implementation of Independent Learning Campus Merdeka (MBKM). The focus of this research consisted of two namely 1) The Design of MBKM in the biology education study program of the Teaching and Education Faculty of Cokroaminoto Palopo University and 2) MBKM Policy at College of Cokroaminoto Palopo University. The MBKM design based on scientific research in the Biology Education study program includes the following: 1) Determination of learning outcomes, 2) Learning activities, 3) Evaluation system and 4) Study load. Cokroaminoto Palopo University is contained in the Handbook for the implementation of MBKM within the scope of Cokroaminoto Palopo University. General policies regarding the implementation of MBKM include 1) Free Student Exchange (PMM), 2) Apprenticeship/work practice based on experiential learning, 3) Teaching assistance in educational units, 4) Humanitarian projects, 5) Entrepreneurial activities, 6) Independent Studies, 7) Thematic Field Work Lecture (KKN-Thematic) is an effort to build villages and 8) research. The resylts of the research is Cokroaminoto Palopo University has developed and implemented a curriculum oriented to the Indonesian National Qualifications Framework (KKNI) regulated in Permendikbud RI No. 73 of 2013 concerning the Application of the Indonesian National Qualifications Framework in the Field of Higher Education
Desain Media Pembelajaran Prakarya Berbasis Smart Apps Creator
Authors: Nasir Nasir , Nurindah Nurindah , Rauf Alfira , Ayu Sadriana , Hambali Uyunnasirah
Published: February 2023

The aims of this study is to produce learning media in Android-based craft subjects through valid and practical smart apps creator applications at SMPN 12 Bulukumba. The research method used is the Research and Development (R&D) method. The development model used refers to the 4D development model (Four D-Model) consisting of 4 stages, namely: define, design, development and dessimeninate. However, this research was only carried out at the development stage. Because this research is only limited to developing and producing Android-based learning media products through smart application maker applications. The research was conducted in class VII SMPN 12 Bulukumba with 30 students and 1 teacher. The research instruments used were media and material expert validation sheets, student and teacher response questionnaires. The data collection technique used was the validation test and student response questionnaires. The results of the development show that learning media based on smart apps creator based on the assessment aspect obtained an average value of 3.70 with a very valid category. Meanwhile, the assessment of material experts is also in a very valid category with an average value of 3.70. The results of the small group trial assessment obtained an average value of 3.27 in the good category. While the results of the small group test obtained an average of  with practical criteria while in the limited field test an average score of = 3.44 with very practical features and for teacher responses obtained an average average =3.65 with very practical features. Based on the results of research conducted through the development process, the researchers concluded that the learning media developed were valid and practical to use
PERLINDUNGAN HUKUM ATAS PELANGGARAN PEMBAJAKAN HAK CIPTA VIDEO DI SITUS YOUTUBE
Authors: Setiada Sinurat Tedy
Published: February 2023

Penelitian ini ditujukan dengan maksud untuk mengetahui secara mendalam perlingungan hak cipta video atas pembajakan di situs youtube. Dua masalah yang diperiksa yaitu : 1. Bagaimana perlindungan hukum atas pembajakan video yang diunggah di situs YouTube? 2. Apa saja Upaya Penyelesaian jika terjadinya sengketa dibidang hak cipta atas karya video yang ada di situs YouTube? Penelitian ini dilakukan dengan menggunakan pendekatan Yuridis Normatif karena bahan pustaka digunakan sebagai bahan utama, yaitu bahan hukum primer yang terdiri dari norma dasar atau kaidah, ketentuan atau peraturan dasar, serta peraturan perundang-undangan yang berhubungan dengan perlindungan perlingungan hak cipta video atas pembajakan di situs youtube dan upaya penyelesaian sengketa. Hasil penelitian menunjukkan bahwa 1. Hak Cipta atas Karya Video mendapatkan perlindungan Hukum yang dilindungi oleh Undang – Undang Nomor 28 Tahun 2014 Tentang Hak Cipta sebagai Jenis Ciptaan Sinematografi yang memiliki hak eksklusif berupa hak ekonomi dan hak moral yang keduanya didapatkan berdasarkan Prinsip Deklaratif dan melarang seseorang menayangkan, menggandakan ulang ciptaan, mengunduh ciptaan yang menyampingkan hak eksklusif pencipta dan pemegang hak cipta. 2. Upaya Penyelesaian sengketa dapat berupa non-litigasi yaitu penyelesaian sengketa diluar pengadilan seperti mediasi, konsiliasi dan arbitrase maupun jalur litigasi yaitu mengajukan gugatan ke pengadilan niaga.
Rokat Kampong: wujud akulturasi Islam dalam budaya lokal
Authors: Hasanah Uswatun , Rosyidi Rosyidi
Published: February 2023

Akulturasi budaya merupakan fenomena yang terjadi ketika budaya asing atau budaya tertentu masuk ke dalam masyarakat yang memiliki budaya lokal. hal ini terjadi karena adanya dialektika antara berbagai budaya yang diterima oleh masyarakat setempat. Kebudayaan merupakan bagian penting dari suatu masyarakat karena masyarakat dan kebudayaan tidak dapat dipisahkan satu sama lain. Kebudayaan merupakan hasil karya masyarakat yang saling berinteraksi satu sama lain. Dalam hal ini terjadi akulturasi dalam program Kampung Rokat yang dilaksanakan di Tojeren Pragaan Daya Pragaan Sumenep. Dalam programnya, masyarakat mempertahankan nilai-nilai budaya lokal yang mereka terima dari nenek moyang mereka, tetapi mereka juga memasukkan unsur atau kegiatan Islami ke dalam implementasinya. Masuknya aktivitas Islam dalam budaya lokal ini melahirkan budaya baru yang disebut Kampung Rokat yang merupakan bentuk akulturasi budaya. Penelitian ini dilakukan untuk melihat wujud implementasi Kampung Rokat dalam akulturasi Islam. Penelitian ini merupakan penelitian fenomenologi deskriptif dengan pengumpulan data melalui wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa masyarakat melaksanakan program Kampung Rokat dengan memasukkan kegiatan Islami namun tidak meninggalkan budaya lokal yang telah mereka terima dari nenek moyang mereka. Melalui berbagai prosesi kegiatan keislaman dan penyembelihan kambing dalam program Kampung Rokat ini serta penguburan kepala, kokot kambing dengan kepercayaan, prosesi doa tertentu, merupakan bukti akulturasi Islam dalam budaya setempat.
How COVID-19 Emergency Practitioner Licensure Impacted Access to Care: Perceptions of Local and National Stakeholders
Authors: Nguyen Ann M. , Farnham Jennifer J. , Ferrante Jeanne M.
Published: February 2023

The COVID-19 public health emergency required US states to respond rapidly on regulatory issues, including the process for licensing healthcare practitioners. At least 45 states enacted some form of a licensure waiver, enabling practitioners to temporarily work across state lines. We conducted 22 interviews with national and local (New Jersey) licensure stakeholders in September and October 2021 to capture perceptions of how emergency licensure impacted access to care. Five themes emerged: (1) Emergency licensing helped shift the nation’s healthcare workforce supply into regions and specialties of high need; (2) Expanded telehealth capacities complemented emergency licensure programs; (3) Concerns about care quality were mitigated by the urgency of the pandemic, credentialing processes, and investigative authorities; (4) Relocation packages and the need to replace staff could lead to higher costs of care; and (5) Views on licensure reciprocity and interstate compacts were favorable, but smaller provider organizations need to be protected. Overall, stakeholders perceived emergency licensure as successful in expanding access to care during the pandemic. Findings suggest that stakeholders view interstate licensure compacts more favorably now than pre-COVID. While stakeholders may be in favor of licensure reciprocity, they raised concerns about its feasibility, cost, and quality.
Objective and Subjective Evaluation of Endotracheal Tube Cuff Pressure between Different Levels of Anesthesia Experiences
Authors: ÇARDAKÖZÜ Tülay , ÇINAR KÖSE Elif Özge , YUCAL Nur Nazire , BALCI Sibel
Published: February 2023

Objective: After endotracheal intubation (ETI), the endotracheal tube cuff (ETTc) should be inflated at sufficient pressure to function, and high pressure should be avoided to prevent complications. In our study, the effect of professional experience on the estimation of ETTcP by palpation is investigated.
Method: The study included 75 adult patients with physical status I-III of the American Society of Anesthesiology (ASA) scheduled for ETI. Anesthesia residents were divided into two groups of 20, each with 1 month to 1 year of experience (Group 1) and those with more than 4 years of experience (Group 2). After the ETI, one participant in both groups was asked to inflate the ETTc to an estimated 25 cm H2O by cuff palpation. Then the actual ETTcP was measured with a manometer.
Results: The median ETTcP value was 42,00 cm H2O in Group 1 and 32,00 cm H2O in Group 2, (p=0.012). Although the data of both groups were significantly higher than the target value, the values obtained in Group 1 were further away from Group 2 (p<0.001, p<0.001).
Conclusion: Professional experience has no effect on the correct estimation of the ETTcP. It is more convenient to measure the actual pressure to avoid undesirable effects of ETTcP outside the target.
Skin Prick Test Reactivity to Common Allergens among Allergic Rhinitis Patients in Kocaeli Province, Turkey
Authors: YAYLACI Atılay
Published: February 2023

Objective: The identification of the most common aeroallergens causing allergic rhinitis (AR) in a specific geographic area is important in the diagnosis and treatment of AR. This study evaluates the prevalence of sensitivity to aeroallergens among patients with AR who live in Kocaeli province, Turkey.
Methods: This cross-sectional, descriptive study included a retrospective review of skin prick test (SPT) results from patients with suspected AR who were examined at a tertiary hospital rhinology clinic.
Results: The SPT results of 85 patients with an AR diagnosis were included in this study. House dust mites (HDM) had the highest frequency of positive test responses (57.6%), followed by tree pollen (40.0%), grass pollen (36.5%), weed pollen (32.9%), cockroach (18.8%), animal dander (14.1%), and mold (11.8%). The majority of the AR patients were polysensitized (57.6%), and the most common allergens in polysensitized patients were tree pollen (61.2%), grass pollen (57.1%), and HDM (55.1%), respectively. The strongest single allergen in monosensitized subjects was HDM, with a rate of 61.1%.
Conclusion: The most prevalent allergen was HDM among AR patients in the Kocaeli region, followed by tree pollen and grass pollen. Polisensitization occurs more frequently than monosensitization. These allergens should be prioritized in the diagnosis and treatment of allergic rhinitis in Kocaeli region patients.
The Effects on the Profession Choice of Nursing Students of the Reflectons of Nurses Working in the COVID-19 Pandemic
Authors: ŞAHİN Şükriye , ELİBOL Neriman
Published: February 2023

Obejective: The aim of the study is determine the effects of working of nurses in the COVID-19 pandemic process, with a reflections on the visual and written media, on the choices of nursing profession of nursing students.
Methods: The sample of this descriptive study consists of 80 first-year nursing students from Kocaeli University Faculty of Health Sciences Department of Nursing, who accepted to participate in the study in the 2020-2021 academic year. “Nursing Student Personal Information Form”, “Nursing Image Scale (NIS)” and “Scale of Vocational Choice in Nursing (SVCN)” were used to collect the research data.
Results: The Median and Q1-Q3 SVCN score of the nursing students was found to be 91.5, (73.5-118). Professional fitness sub-dimension median and Q1-Q3 score was 63.5, (49-82) and vital causes sub-dimension median and Q1-Q3 score was determined as 27.5, (19,5-34,5). NIS median and Q1-Q3 score 73.0, (68-76), general appearance sub-dimension median and Q1-Q3 score was 15.0, (14-16), communication sub-dimension median and Q1-Q3 score was 16.0, (14-17), professional and physical qualities sub-dimension median and Q1-Q3 score were found to be 42.0, (40-43). During the COVID-19 pandemic, the median scores of the professional and physical qualities sub-dimension of those affecting the choice of profession were found to be significantly lower (p=0.033).
Conclusion: It was concluded that the first-year nursing students' thoughts about the nursing impression were positive and they chose nursing willingly and the media reflections of nurses during the pandemic process increased their sense of helping people.
Formulation and Physical Stability Test Preparation of Anti-Acne Gel Extract of Tebu Leaves (Saccharum officinarum (Linn) as Antibacterial Against Staphylococcus Epidermis
Authors: Arif Wijayanto  , Juvita Herdianty
Published: February 2023

Increased processing of Tebu as sugar causes the resulting waste, namely the shoots of Tebu leaves. The phenolic and flavonoid compounds in Tebu are reported to have strong antioxidant, anti-inflammatory, antimutation and tyrosine inhibitor activities. Infectious diseases are diseases caused by the presence of pathogenic microbes, one of which causes infection, namely bacteria. Utilization of Tebu waste is expected to produce alternative products in the form of antibacterial preparations, especially anti-acne. Staphylococcus epidermis is one of the bacteria that causes infection on skin with acne. This study aims to determine the physical stability of the preparation Tebu leaf extract anti acne gel and its antibacterial activity against Staphylococcus Epidermis bacteria. Methods: This research design is an experimental method, making Tebu leaves extract by weighing as much as 400 grams of fine powder of Tebu leaves then put in a maceration container, closed then added 70% 2 liters of ethanol until completely submerged and stored for 24 hours protected from direct sunlight while stirring occasionally. Then filtered, separated the dregs and filtrate. The dregs were re-extracted with the same amount of new 70% ethanol for 2 days. The obtained 70% ethanol filtrate was evaporated to obtain a thick extract using a Vacuum Rotary Evaporator. Tebu leaves extract gel was made at a concentration of 5%, 10%, 15% and an antibacterial test was carried out using the well diffusion method. Results: The results of the physical stability test of the acne extract cream showed that the results met the requirements both in terms of pH, dispersion test, homogeneity. The results of the antibacterial test of Tebu leaves extract showed the presence of a zone of bacterial inhibition which was indicated by the presence of a clear area around the well. Conclusion: The results of the evaluation showed that the Tebu leaves extract gel met the requirements for the physical quality of the gel preparation, both organoleptic, pH, viscosity, adhesion, and spreadability. Tebu leaves extract gel was able to inhibit the growth of S. epidermis bacteria with the best concentration in 3rd formula, consentration 15% Tebu leaves extract gel.
The Relationship between the Implementation of Nursing Supervision with the Performance of Nursing in Patient Room at Dumai City General Hospital
Authors: Suci Amin  , Dilgu Meri  , Dewi Anggraini
Published: February 2023

An assurance for the patients' health care is a nurse's quality care. In order to maintain the standard of care provided in a unit, one of the managerial responsibilities of a nurse manager is to oversee the nurses. The goal of this study was to ascertain how well nurses performed in the inpatient unit of Dumai City General Hospital in relation to the use of nursing supervision. With samples of 118 nurses, the research design described cross-sectional correlation. The research tool was a questionnaire with a 57.1% supervision and a 43.9% performance ratio. Purposive sampling was used to take the sample. The findings of the chi square analysis revealed a relationship between the performance of the nurses in the inpatient room at Dumai City General Hospital and the supervision provided by the nurse management (p=0,000=0,05). The administration of Dumai City General Hospital is hoped to strengthen nursing supervision activities in order to enhance the performance of the nurses in providing patient care.
Husband Support on Pregnant Mother's Anxiety in Facing Labor During the Covid-19 Pandemic in Tamanan Kediri 2022
Authors: Meirna Eka Fitriasnani  , Rahma Kusuma Dewi  , Siti Aminah  , Tira Gustiara Dewi  , Dwi Ayu Lestari
Published: February 2023

Husband's support is a very important factor in the delivery process, because the husband can foster feelings of confidence and form a strong mentality towards his wife so that anxiety and fear disappear. In addition, cooperation between family and husband in providing good support for pregnant women can also eliminate the worry of pregnant women about the delivery process that will be carried out by pregnant women. The design of this research is correlational analytic. The population in this study were pregnant women in Tamanan Village, Kediri City in May 2022.  In this study, the sampling technique used simple random sampling The research instrument is a questionnaire sheet.The results showed that half (50%) of the respondents who received good husband support experienced mild anxiety, namely as many as 6 respondents, almost all (76.92%) who received sufficient husband support experienced moderate anxiety, namely as many as 20 respondents. Based on the results of statistical tests using the Spearman Rank correlation test (Rho) on the husband's support variable (X) and anxiety level (Y) obtained ρ value = 0.002 with a confidence level of α = 0.05, it can be concluded that ρ < α then H0 is rejected and H1 is accepted, meaning that there is a relationship between husband's support and anxiety levels in third trimester pregnant women. Based on the results of the study, there was an effect of husband's support on the anxiety of pregnant women in the third trimester in facing childbirth during the covid 19 pandemic in Tamanan Village, Kediri City in 2022. Suggestions for research sites to motivate husbands to increase their role psychologically throughout the process experienced by their wives includes pregnancy, childbirth, postpartum to the decision-making process in family planning.
The Effect of Prenatal Yoga on Perineal Lacerations in Maternity Mothers at Midwife's Independent Practice Place in the Working Area of Tanjunganom Public Health Center, Nganjuk Regency 2022
Authors: Miftakhul Mu’alimah  , Dewi Kartikasari  , Sunaningsih  , Yunita Puspita Sari Pakpahan
Published: February 2023

Childbirth is a physiological process that allows a series of great changes in the mother to be able to give birth to her fetus through the birth canal. During the delivery process, the mother often has lacerations or tears in the perineum. According to a preliminary study conducted at BPM in the working area of puskemas Tanjunganom Nganjuk, it was found that out of 10 maternity mothers, 6 (60%) of them experienced 3rd degree lacerations and 2 (20%) had 2nd degree lacerations and 2 (20%) maternity mothers experienced 1st degree lacerations. The purpose of this study is to analyze the effect of pregnant yoga on the incidence of perineal lacerations in maternity mothers at midwife’s independent practice palace in the Working Area Of Tanjunganom’s Public Health, Nganjuk Regency 2022. The research method used is quasy experiment with desaign posttest only control design research. The sample in this study was maternity mothers in July until October 2022 who were distinguished between the control group and the treatment group. The results showed that there was an influence of pregnant yoga on the incidence of perineal lacerations in maternity mothers with a value of ρ value 0.000 < α 0.05 with a difference in lacerations of degrees 1 and 3. From the results of this study, it can be concluded that pregnant yoga is very effective in preparing the elasticity of the perineal muscles so that it can help to prevent rupture during the labor process.
El interrogatorio de menores: una prueba –a veces pericial– a evitar
Authors: Nieva Fenoll Jordi
Published: February 2023

El interrogatorio de menores es un medio de prueba que cada vez se practica menos, por fortuna, en la línea de la protección internacional de la vulnerabilidad ínsita a un menor. Sin embargo, su variedad pericial tampoco está exenta de varios inconvenientes estrictamente científicos que desaconsejan su práctica salvo cuando sea estrictamente necesaria. En particular, no parece procedente la práctica de la prueba utilizando una cámara de Gesell, que en realidad supone una resistencia a reconocer la escasa eficiencia probatoria de los interrogatorios en general.
Relationship between Number of Mature Follicles and Pregnancy Rates in IUI Cycles in Women 38 to 43 Years Old
Authors: Steiner Naama , Al Shatti Maryam , Frank Russell , Rotshenker-Olshinka Keren , Ruiter-Ligeti Jacob , Dahan Michael H.
Published: February 2023

Background: Although the number of follicles at intrauterine insemination (IUI) is associated with the pregnancy rates and multiple pregnancy rates. Multiple pregnancy rates are low in older women. Therefore, this study was undertaken to determine the clinical pregnancy rate of IUI in women 38–43 years of age based on the number of stimulated mature follicles. Methods: A retrospective cohort study was performed including all the first to third stimulated IUI cycles conducted after the age of 38 years in a single academic fertility center between January 2011 and March 2018. Results: A total of 1574 IUI cycles were included in the study. The patients were divided according to the number of mature follicles (>14 mm in diameter) at the last ultrasound before the human chorionic gonadotropin (hCG) trigger. The total pregnancy rate was 9.1% and only 5 multiple pregnancies occurred. The parity (p = 0.049), the number of follicles 10–14 mm (p = 0.002), and the peak endometrial thickness (p = 0.003) were significantly different between the groups. No statistical difference was observed between the groups regarding pregnancy rates (p = 0.93) and clinical pregnancy rates (p = 0.21). Multivariate logistic regression controlling for confounding effects comparing clinical pregnancy rates with the standard as 1 follicle 14 mm or greater as benchmark did not alter the results. Conclusions: In women 38 to 43 years of age undergoing controlled ovarian hyperstimulation (COH)/IUI, one mature follicle yielded similar pregnancy and clinical pregnancy rates compared to multiple follicles, possibly due to the aneuploidy rate at this age.
Web-Based Obstetrical Ultrasound Curriculum Tested by Medical Students in Spain: A Pilot Study
Authors: Webber Whitney , Donazar Mikel , Taylor Lesli , Almeida Mariana Crista , Diaz Andreina Manuela Culebras , Van Horn Alexandra , Seybold Dara J. , Calhoun Byron C.
Published: February 2023

Background: Medical education continues to face challenges particularly with the increased need for high quality accessible curricula delivered in a time effective manner. The purpose of the study was to assess feasibility and student learning with a web-based training program in ultrasound for limited obstetrics and gynecology. Methods: We created a six-module E-learning program (5 didactic modules and 1 biometry module) that contains quizzes and interactive labs, designed to complement an in-class lecture. Medical students were evaluated with a pre- and post-test. A web-based ultrasound curriculum was delivered to 27 fourth and fifth year Spanish medical students with English fluency at a university in Spain during a maternal-fetal medicine elective course from September 16–23, 2019. Results: Twenty-six students were able to demonstrate pre- and post-test score improvement following the web-based ultrasound education (median test score 160 pre vs. 290 post). A web-based ultrasound curriculum can be effective at increasing students’ knowledge of ultrasound material, while saving in person instructional time for other materials. Students enrolled in this course demonstrated exemplary dedication to learning on their own time outside of the classroom. This opportunity freed up lecture time to cover other material. Conclusions: Web-based ultrasound curriculum provides a valid model in adapting remote education for medical training.
Analysis of the Efficacy of LNSRH Surgery for Early Cervical Cancer Based on T, B, and NK Lymphocytes
Authors: He Lijie , Ma Liangliang , Zhang Heping
Published: February 2023

Background: The analysis is based on the level of T, B, NK lymphocytes to evaluate the efficacy of laparoscopic nerve-sparing radical hysterectomy (LNSRH) for early cervical cancer. Methods: Selected 30 patients with early cervical cancer who underwent LNSRH surgery in Tianjin Fifth Central Hospital from December 2019 to January 2021 as the cervical cancer group, and 30 healthy female who underwent physical examination in our hospital during the same period were selected as the control group. The expressions of CD4+, CD8+, CD20+, and CD57+ were detected by flow cytometer, female sexual function index (FSFI) and overall assessment scale of cancer treatment function (FACT-G) score were used to evaluate female sexual function and quality of life, and the receiver operating characteristic curve (ROC) was used to analyze the expression predictive value of CD4+, CD8+, CD20+, and CD57+ in LNSRH of early cervical cancer. Results: The expression of CD4+ and CD57+ in the cervical cancer group was lower than that in the healthy group,and the expression of CD8+ and CD20+ was higher than that in the healthy group (p < 0.05). The expression of preoperative CD4+ and CD57+ was higher for postoperative, and the expression of preoperative CD8+ and CD20+ was lower (p < 0.05) for postoperative. The expression of postoperative 1 day CD4+ and CD57+ was higher for at 3 days postoperative, and the expression of postoperative 1 day CD8+ and CD20+ was lower at 3 days postoperative (p < 0.05). CD4+, CD57+ expression was positively correlated with FSFI score, and CD8+, and CD20+ expression was negatively correlated with FSFI score, CD4+, and CD57+ expression was positively correlated with FACT-G score, and CD8+, and CD20+ expression was negatively correlated with FACT-G score (p < 0.05). ROC analysis of CD4+, CD8+, CD20+, CD57+ expression sensitivity was lower than the four-item combination, the specificity was higher than the four-item combination and the results with significant statistical difference (p < 0.05) and the four combined tests have good predictive value for the efficacy of LNSRH for early cervical cancer (p < 0.05). Conclusions: Cervical cancer patients were mainly cellular immunity and performed low expression of CD4+, high expression of CD8+, high expression of CD20+, and low expression of CD57+. T, B, and NK lymphocytes could be used for immunological detection of cervical cancer.
Determinants of Severe Late Ovarian Hyperstimulation Syndrome in Fresh Embryo Transfer Cycles Based on Integration of Decision Tree Classification and Conditional Logistic Regression
Authors: Lin Lijun , Yuan Xuelian , Li Xiaohong , Hunt Sarah , Chen Ge , Luo Shan , Li Xiaohong
Published: February 2023

Background: To explore possible predictors of severe late ovarian hyperstimulation syndrome (SL-OHSS) in fresh embryo transfer cycles. Methods: We conducted a historical cohort study in a Chinese tertiary hospital from January 2017 to December 2019, with a total of 6931 women who had the first fresh embryo transfer included. SL-OHSS was defined as severe symptoms of OHSS occurring 12–17 days after ovulation triggering. Possible determinants of the occurrence of SL-OHSS were identified by a detection decision tree, effects of which were estimated by conditional logistic regression and restricted cubic spline. Results: Elevated estradiol (E2) on the day of ovulation triggering and elevated Anti-Mullerian hormone (AMH) were associated with an increased risk of SL-OHSS (p < 0.001). Women with an E2 on trigger day of ≥3320.2 pg/mL (odds ratio (OR): 2.20; 95% confidence interval (CI): 1.03–4.68), or with an E2 on trigger day of <3320.2 pg/mL and an AMH of ≥4.62 ng/mL (OR: 5.44; 95% CI: 2.29–12.90), had an increased risk of SL-OHSS compared to their counterparts. Women with E2 on trigger day of >3320.2 pg/mL and AMH of >4.62 ng/mL had the highest risk of SL-OHSS (OR: 13.20; 95% CI: 3.87–45.02) when compared with E2 on trigger day of ≤3320.2 pg/mL and AMH of ≤4.62 ng/mL. This association was not linear. Conclusions: Serum E2 concentration on trigger day and AMH levels at baseline may predict SL-OHSS occurrence in fresh embryo transfer cycles. These biomarkers may be valuable in determining the optimum transfer strategy to limit the occurrence of SL-OHSS.
Dietary Ochratoxin A Contamination Modulates Oxidative Stress, Inflammation Processes and Causes Fibrosis in in vitro and in vivo Lung Models
Authors: Ou Yongfang , Fu Qiujuan , Chen Yonghua , Lin Liyao , Wang Junfeng , Wu Dong , Wu Qin , Xie Jianlong
Published: February 2023

Background: The prevalence of aging-related diseases has increased significantly and this imposes a burden on both families and society. The lung is one of the few internal organs that is continuously exposed to the external environment, and lung aging is associated with a number of lung diseases. Ochratoxin A (OTA) is a toxin that is widely present in food and the environment but an effect for OTA on lung aging has not been reported. Methods: Using both cultured lung cell and in vivo model systems, we studied the effect of OTA on lung cell senescence using flow cytometry, indirect immunofluorescence, western blotting, and immunohistochemistry. Results: Results obtained showed that OTA caused significant lung cell senescence in cultured cells. Furthermore, using in vivo models, results showed that OTA caused lung aging and aging fibrosis. Mechanistic analysis showed that OTA upregulated the levels of inflammation and oxidative stress, and that this may be the molecular basis of OTA-induced lung aging. Conclusions: Taken together, these findings indicate that OTA causes significant aging damage to the lung, which lays an important foundation for the prevention and treatment of lung aging.
Differential expression of RIMS1 in pancreatic cancer.
Authors: Mamoor Shahan
Published: February 2023

Cancer is a leading cause of death and pancreatic cancer is among the most lethal cancers (1, 2). We mined public and published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with pancreatic cancer, pancreatic adenocarcinoma (PDAC). We found significant differential expression of the gene encoding regulating synaptic membrane exocytosis 1, RIMS1, when comparing pancreatic tumors to the tissue of origin, the pancreas. RIMS1 mRNA was present at significantly lower quantities in tumors of the pancreas as compared to normal pancreatic tissue. Analysis of human survival data revealed that expression of RIMS1 in pancreatic tumors was correlated with overall survival in patients with pancreatic adenocarcinoma. RIMS1 expression changes may be important for the initiation or progression of human PDAC.
Caring-Based Curriculum Design in Helping & Healing Profession and Discipline: Theoretical Integration and Pedagogical Innovation in an Undergraduate Nursing Curriculum
Authors: Martinez Rudolf Cymorr Kirby Palogan
Published: February 2023

The pandemic experience has brought up issues and concerns about the competencies of healthcare workers, especially those working in hospitals, especially nurses. The importance of caring, creating caring moments, and being a caring healthcare provider has been essential to all persons during the pandemic, whether Covid-19 afflicts them or not. Post-pandemic, the central question of, "are we educating nurses to be caring professionals or to be mere technicians?" needs more reflection as the realities of another pandemic emerging is well within the horizon. If caring is considered by many nurses as the essence of nursing and is fundamental to the nursing discipline and profession, how is it reflected in the current curriculum for an undergraduate degree in nursing? If it is not fully articulated as one of the basic requirements for the undergraduate curriculum in nursing, how do we functionally integrate it into our respective curriculum?These fundamental questions guide the flow and discussion of this paper as educating the next generation of nursing to explicitly express caring attributes in their professional practice rest upon the institution’s curricular development and innovations. As Smith & McCarthy (2010) greatly emphasized, the preparation of the next generations of nurses in the knowledge of the discipline of nursing will determine the potential for advancing the health of society through nursing’s unique contributions at a time of national healthcare crisis when they are most needed.This paper is composed of three distinct parts; first, the discourse of the philosophical and theoretical assumptions that serve as the grounding for curriculum innovation. Second is the exploration of the current context of caring in nursing education, emphasizing the need for the infusion of caring in the undergraduate nursing curriculum. Lastly, the presentation of the process by which caring is functionally integrated and fully articulated in the current BSN curriculum of San Beda University College of Nursing.