bluuebunny/crossref_metadata_2025 huggingface dataset:
Employee Capital Plans performance through the lens of the participant — how to (better) measure and inform about the returns
Authors: Barembruch Adam , Bielawska Kamila
Published: July 2023

In recent decades, an increased effort to increase private retirement savings can be observed, especially in countries where public pensions have been the main source of livelihood during retirement. To increase participation in occupational as well as individual pension plans, states often use financial incentives (personal income tax reductions, preferential tax rates, subsidies). However, experience from studies in various countries shows that these incentives may not be efficient and/or attract mainly high earners. Mobilizing Poles to save for retirement in light of the paradigm shift in pension security in Poland caused by the 1999 reform has proven to be a major challenge. Given the mediocre development of the private pension plan market, a new type of workplace pension plans based on automatic enrollment called Employee Capital Plans (ECP) began to be implemented in 2019. However, despite the plan’s favorable funding mechanism, especially from the perspective of low- and middle-income earners, participation remains low. In the article, we argue that a change in the manner in which program participants are being reported their earned rates of return could increase interest in ECP participation. Following the investment performance of 60 FZDs, operating within the framework of ECP in Poland, we show that the total returns presented by the managers of FZDs and Polish FSA are lower than the returns measured from the perspective of participant contributions using the IRR method. Significantly higher results are also achieved by those with low earnings, who can make reduced contributions to ECP. Thus, we recommend the introduction of a standard for the presentation of ECP investment results from the participant’s point of view, taking into account the ECP financing mechanism.
Comprehensive Breastfeeding Education: An Integration to Support Successful Breastfeeding Practice
Authors: Burhan Rialike , Destariyani Elvi , Yanniarti Sri , Yuniarti Yuniarti , Solihat Suci
Published: July 2023

Breast milk is the best food for newborns, but the coverage of exclusive breastfeeding worldwide is only 40% (WHO, 2018). Babies who are not breastfed more susceptible to infectious diseases. The incidence of infants suffering from recurrent infectious diseases will result in malnutrition. The success of exclusive breastfeeding is largely determined in the first week of birth period as a critical phase in breastfeeding, so it is necessary to support comprehensive breastfeeding. The purpose of this study was to determine the effect of comprehensive breastfeeding education on the success of breastfeeding postpartum mothers in the Midwifery Independent Practice in Bengkulu City. The method used in this study was a quantitative pre-experiment with a two-group pre-posttest approach. The sample was taken by non-probability sampling by accidental sampling, in total 30 respondents. The group that was given the intervention was in the form of education in classes for pregnant women using a comprehensive breastfeeding education book, while the comparison group was given book only. The research variables studied were breastfeeding success (knowledge, attitudes, and breastfeeding practices) and external variables (age, parity, education, early initiation of breastfeeding, and husband support). Analysis test using Wilcoxon and Mann Withney and Ancova. The results showed that there was a significant effect of comprehensive breastfeeding education on attitudes, knowledge of successful breastfeeding practices (p<0.05). The implications of this research can be used as a reference as a development effort to increase breastfeeding success.
The Effect of Nutrition Education on Knowledge, Attitudes and Consumption Patterns of Young Women in Prevention of Chronic Energy Deficiency in Bengkulu City
Authors: Kamsiah Kamsiah , Yuliantini Emy , Eliana Eliana , Rachmawati Rachmawati
Published: July 2023

Adolescents is one of age groups vulnerable to nutritional status. Adolescence requires higher nutrition in order to optimize physical, cognitive and psychosocial growth. Lifestyle and diet of adolescents will affect the fulfillment of nutritional needs. Nutrition education can be carried out properly and can be received directly depending on how the message is conveyed, how the message is received and where the message is delivered. Barriers to prevention of chronic energy deficiency in adolescents can be sourced from environmental influences. Several studies The existence of significant changes in behavior in eating patterns through interventions from nutrition education can prevent Chronic Energy Deficiency (CED) in adolescents. This research aims to evaluate the impact of nutrition education on knowledge, attitudes and consumption patterns in prevention of CED in Young Girls SMPN 19 Padang Serai and SMKS Kampung Bahari, Bengkulu City. This study used quasi experiment with a two-group pre-test and post-test design.  The intervention was carried out in the form of nutrition counseling using booklets or modules with a frequency of 3 meetings in 3 weeks. Nutrition education is promoting nutrition messages through education with a learning process using booklets individually and in groups using the lecture method. This study resulted an increased in knowledge, attitudes and consumption patterns after being given nutrition education in prevention of chronic energy deficiency of young women in Bengkulu City (p=0.000). There is an increase and influence between knowledge, attitudes and consumption patterns after being given adolescent nutrition education.
Effectiveness of Red Guava Juice (Psidium guajava L.) and Crystal Guava Juice (Psidium guajava L. “Crystal”) on Physical Fitness of Female Adolescents with Anemia
Authors: Mayasari Devi Ratna , Sari Yulia , Febrinasari Ratih Puspita
Published: July 2023

Anemia often occurs in female adolescents cause by iron deficiency. Adolescents are diagnosed anemia if the hemoglobin level is <12 g/dl. Someone who has anemia is prone to have low physical fitness. Consumption of foods that are high in iron and vitamin C such as guava juice can help improve physical fitness. The aim of this study was to analyze the effect of red guava juice and crystal guava juice consumption on physical fitness in female adolescents with anemia. The design of this study was a quasi-experimental with pre and post-test control group design with 36 subjects divided into 3 groups, namely control (iron tablets), P1 (iron tablets + red guava juice), P2 (iron tablets + crystal guava juice). Red guava juice and crystal guava juice given 200 ml per day for 30 days. The physical fitness test uses the Harvard Step Test method with a Physical Efficiency Index assessment. Physical fitness before and after control group had a difference of 1.84±15.86, the difference in P1 group was 17.20±20.35, and the difference in P2 group  was of 19.69±15.58. Based on the results of statistical tests, it was found that there were differences in the three groups before and after the intervention p=0.031 (p<0.05). Giving red guava juice and crystal guava juice can be an alternative to improve physical fitness in female  adolescents with anemia, but crystal guava juice is the most effective in increasing physical fitness in female adolescents with anemia.
Gaguk Fish Nugget Formulation (Arius Thalassinus) With Addition of Moringa Leaf Flour (Moringa Oleifera)
Authors: Dianti Reva , Simanjuntak Betty Yosephin , Tetes Wahyu W
Published: July 2023

The aim of this study was to determine the effect of adding moringa leaf powder to crawfish-based nuggets to the organoleptic quality and calcium content. The initial stage was the preparation of the ingredients, which continued with the manufacture of moringa leaf flour and optimation of nuggets, as well as organoleptic testing. The best formulation was followed by an analysis of calcium levels. This study involved 30 students as panelists. The results of the Kruskal-Wallis test indicated that there were differences in color and texture with a p value= 0,018 and p value= 0,044, respectively. Mann-Whitney test obtained a p value of 0,450, which indicate no difference in color between formulations 1 and 2, but it was found that there was a color difference in the formulation with the addition of 5 grams of moringa leaf powder (p= 0,005). There was an effect of the addition of moringa leaf powder between formulations F2 and F3 with p= 0,034 and p= 0,034 on the texture between formulations 1 and 2, but there was no difference in texture between formulations 1 and 3 with a value of p= 0,800. The calcium levels in nuggets with the addition of 10 grams of leaf flour moringa was 289 mg/%. Nuggets with the addition of 10 grams of moringa leaf flour (F2) were the most preferred by the panelists in terms of taste and texture, and the calcium content could meet 30 percent of the Recommended Dietary Allowance (RDA).
The Solar System: Nature and Mechanics
Authors: Ljubičić Mario
Published: July 2023

Origin, mechanics and properties of the Solar System are analysed in the framework of the Complete Relativity theory (by the same author). According to Complete Relativity, everything is relative. Any apparent absolutism (notably invariance to scale of dimensional constants, absolute elementariness, invariance to time) is an illusion stemming from limits imposed by [or on] polarized observers that will inevitably lead to misinterpretation of phenomena (another illusion) occurring on non-directly observable scales or even on observable but distant scales in space or time. If everything is relative, reference frames will exist where particles are planets and where planets are living beings. Earth is, therefore, analysed here in more detail, both as a particle and, as a living evolving being (of, hypothesized, extremely introverted intelligence). The analysis confirms the postulates and hypotheses of the theory (ie. existence of discrete vertical energy levels) with a significant degree of confidence. During the analysis, some new hypotheses have emerged. These are discussed and confirmed with various degrees of confidence. To increase confidence or refute some hypotheses, experimental verification is necessary. Main conclusions that stem from my research and are further confirmed in this paper are: universes are, indeed, completely relative; Solar System is a scaled (inflated, in some interpretations) Carbon isotope with a nucleus in a condensed (bosonic) state and components in various vertically excited states; life is common everywhere, albeit extroverted complex forms are present on planetary surfaces only during planetary neurogenesis; anthropogenic climate change is only a part (trigger from one perspective) of bigger global changes; major extinction events on a surface of a planet are relative extinctions, a regular part of transformation and transfer of life in the process of planetary neurogenesis.
Liposomal Epigallocatechin-3-Gallate for the Treatment of In-testinal Dysbiosis in Children with Autism Spectrum Disorder: A Comprehensive Review
Authors: De la Rubia Ortí Jose Enrique , Moneti Costanza , Serrano-Ballesteros Pilar , Castellano Gloria , Bayona-Babiloni Raquel , Carriquí-Suárez Ana Belén , Motos María , Proaño Belén , Benlloch María
Published: July 2023

Autism Spectrum Disorder (ASD) is characterized by varying degrees of difficulty in social interaction and communication. These deficits are often associated with gastrointestinal symptoms, indicating alterations in both intestinal microbiota composition and metabolic activities. The intestinal microbiota influences the function and development of the nervous system. In individuals with ASD, there is an increase in bacterial genera such as Clostridium, as well as species involved in the synthesis of branched-chain amino acids (BCAA) like Prevotella copri. Conversely, decreased amounts of Akkermansia muciniphila, and Bifidobacterium spp. are observed. Epigallocatechin gallate (EGCG) is one of the polyphenols with the greatest beneficial activity on microbial growth and its consumption is associated with reduced psychological distress. Therefore, the objective of this review is to analyze how EGCG and its metabolites can improve the microbial dysbiosis present in ASD and its impact on the pathology. The analysis reveals that EGCG inhibits the growth of pathogenic bacteria like Clostridium perfringens and Clostridium difficile. Moreover, it increases the abundance of Bifidobacterium spp. and Akkermansia spp. As a result, EGCG demonstrates efficacy in increasing the production of metabolites involved in maintaining epithelial integrity and improving brain function. This identifies EGCG as highly promising for complementary treatment in ASD.
Detailed Comparative Analysis of Structural Stability and Electron-Phonon Properties of ZrO2: Mechanism of Water Adsorption on t-ZrO2 (101) and t-YSZ (101) Surfaces
Authors: Nematov Dilshod , Burkhonzoda Amondulloi , Kholmurodov Kholmirzo , Lyubchyk Andriy , Lyubchyk Svitlana
Published: July 2023

The paper considers the issues of structural stability, electronic properties, and phonon dispersion of the cubic, tetragonal, and monoclinic phases of ZrO2. It was found that the monoclinic phase of zirconium dioxide is the most stable among the other two phases in terms of total energy, lowest enthalpy, highest entropy, and other thermodynamic values. The smallest negative modes were found for m-ZrO2. An analysis of the electronic properties showed that during the m–t phase transformation of ZrO2, the Fermi level first shifts by 0.125 eV towards higher energies, and then decreases by 0.08 eV in the t–c cross section. The band gap for c-ZrO2, t-ZrO2, and m-ZrO2 is 5.140 eV, 5.898 eV, and 5.288 eV, respectively. Calculations based on the analysis of the influence of doping 3.23, 6.67, 10.35 and 16.15 mol. %Y2O3 on the m-ZrO2 structure showed that the enthalpy of m-YSZ decreases linearly, which accompanies further stabilization of monoclinic ZrO2 and an increase in their defectiveness. In this case, the position of the Fermi level changes abruptly, and the energy gap decreases. It has been established that not only for pure systems, including those doped with Y2O3, the main contribution to the formation of the conduction band is made by the p-states of electrons. An analysis of the mechanism of water adsorption on the surface of t-ZrO2 (101) and t-YSZ (101) showed that H2O on unstabilized t-ZrO2 (101) is adsorbed dissociatively with an energy of -1.22 eV, as well as by the method of molecular chemadsorption with an energy of -0 .69 eV and the formation of a hydrogen bond with a bond length of 1.01 Å. In the case of t-YSZ (101), water is molecularly adsorbed onto the surface with an energy of -1.84 eV. Dissociative adsorption of water occurs at an energy of -1.23 eV, near the yttrium atom.
Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications
Authors: Ceresa Chiara , Fracchia Letizia , Sansotera Andrea Chiara , Rienzo Mayri Alejandra Díaz De , Banat Ibrahim M.
Published: July 2023

Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability, and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal, and antiviral effects, antioxidant, anticancer, and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formation in clinical, hygiene, and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro and nanoemulsions, and hydrogels, improving drug solubility, stability, and bioavailability and enabling targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analyzing recent literature, this review aims to provide insights into the present understanding, highlight emerging trends, identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.
Low Voltage Network Modeling and Analysis with Rooftop PV Forecasts: A Realistic Perspective from Queensland, Australia
Authors: Anderson Jake , Agalgaonkar Ashish
Published: July 2023

Recent years have seen a rapid uptake in distributed energy resources (DER). Such technologies pose a number of challenges to network operators, which can ultimately limit the amount of rooftop solar photovoltaics (PV) systems that can be connected to a network. The objective of this industry-based research was to determine the potential network effects of forecast levels of customer owned rooftop solar PV on Energy Queensland’s distribution network and formulate functions that can be used to determine such effects without the requirement for detailed network modeling and analysis. In this research, many of Energy Queensland’s distribution feeders were modelled using DIgSILENT PowerFactory and analyzed with forecast levels of solar PV and customer load. Python scripts were used to automate this process and quasi dynamic simulation (QDSL) models were used to represent the dynamic volt-watt and volt-var response of inverters, as mandated by the Australian Standard AS/NZS 4777. In analyzing the results, linear regression was used to form trend equations that represent various network characteristics against the number of PV connections. The trend equations provide a way of approximating network characteristics for other feeders under various levels of customer owned rooftop solar PV without the need for detail modeling.
Characterization and Catalytic Performance of Al-SBA-15 Catalyst Fabricated Using Ionic Liquids with High Aluminum Content
Authors: Aldosari Obaid F. , Hassan Hassan , Alhumaimess Mosaed S. , Betiha Mohamed A. , Ahmed Emad A. , Alhaidari Laila M. , Altwala Afnan
Published: July 2023

This study involved the fabrication of a set of Aluminum ion-grafted SBA-15 utilizing ethylene-diamine and trimethylamine ionic liquids. The primary objective was to examine the impact of the fabrication environment on the physicochemical characteristics of the catalysts. Comprehensive characterization of the Al-SBA-15 catalysts was conducted using various techniques, including XRD, FTIR, surface area, pyridine FTIR, 27Al-NMR, TGA, HRTEM, and FESEM, to analyze their physicochemical characteristics. Furthermore, the acidic characteristics were examined by con-ducting potentiometric titration in a nonaqueous solvent and employing FTIR spectroscopy to an-alyze the chemisorbed pyridine. The effectiveness of the fabricated acid materials was evaluated by testing their performance in the acetic acid esterification with butanol. The findings obtained reveal that the mesostructured of SBA-15 remains intact following the successful inclusion of Al3+ ions into the silica frameworks. Additionally, a remarkable enhancement in the existence of both Bronsted and Lewis acid centers is noted due to the grafting process of Al3+ ions. At temperatures of 80°C and 100°C, the reaction in Al-SBA-15(T-120) proceeds swiftly, reaching approximately 32% and 38% conversion, respectively, within a span of 110 minutes. The excellent catalytic performance observed in the esterification reaction can be attributed to two factors: the homogeneous distribution of Al3+ ions within the SBA-15 frameworks and the acidic character of Al-SBA-15. The findings further indicate that the grafting process for incorporating Al3+ ions into the silica matrix is more efficient.
Unique Evolution Patterns of Hepatitis B and C Viruses Revealed by Continuous Genetic Surveillance from 2015 to 2021 in Gabon, Central Africa
Authors: Abe Haruka , Ushijima Yuri , Bikangui Rodrigue , Ondo Georgelin Nguema , Pemba Christelle M. , Zadeh Vahid R. , Mpingabo Patrick I. , Ueda Hayato , Agnandji Selidji T. , Lell Bertrand , Yasuda Jiro
Published: July 2023

Viral hepatitis remains one of the largest public health concerns worldwide. Especially in Central Africa, information on hepatitis virus infections has been limited, although the prevalence in this region has been reported to be higher than the global average. To reveal the current status of hepatitis B and C viruses (HBV and HCV) infections and the genetic diversity of the viruses, we conducted longitudinal surveillance in Gabon. We detected 22 HBV and 9 HCV infections in 2,047 patients with febrile illness. Genetic analyses of HBV identified subgenotype A1 for the first time in Gabon and an insertion generating a frameshift to create an X-preC/C fusion protein. We also revealed that most of the detected HCVs belonged to the “Gabon-specific” HCV subtype 4e (HCV-4e), and the entire nucleotide sequence of the HCV-4e polyprotein was determined to establish the first reference sequence. HCV-4e strains possessed resistance-associated substitutions similar to those of other HCV-4 strains, indicating that the use of direct-acting antiviral therapy may be complex. These results provide a better understanding of the current situation of hepatitis B and C virus infections in Central Africa, and will help public health organizations develop effective countermeasures to eliminate chronic viral hepatitis in this region.
First-Year Palestinian English Majors’ Attitudes and Expectations towards EFL Learning: A Mixed-Methods Study
Authors: Jabali Oqab , Hamamra Bilal , Saadeh Heba , Ayyoub Ahmad
Published: July 2023

The increasing enrollments in the English Departments at Palestinian universities highlight the need to understand the attitudes and expectations of students, as these factors can significantly impact their motivation and proficiency in learning English as a foreign language (EFL). This study aimed to explore the attitudes and expectations of Palestinian first-year English majors in relation to EFL learning. A total of 244 students participated in the study, completing a questionnaire and participating in interviews to provide a comprehensive understanding of their perspectives. The results revealed a high level of enthusiasm among the students towards EFL, as evidenced by their strong attitudes and exceptionally high expectations. Moreover, the study identified specific student characteristics, including gender and the required hours dedicated to English learning, as well as the experience of studying abroad, which served as predictive factors for their attitudes and expectations. The findings emphasize the importance of regularly assessing the attitudes and expectations of learners in English departments to effectively cater to their needs and attract more students. By understanding the motivating factors and aligning instructional strategies accordingly, English departments can create a more engaging and tailored learning environment for students pursuing English as a foreign language.
Revolutionizing Property Management: e-Perumahan Web-Based Housing Management System
Authors: Uriawan Wisnu , Najib Budi Noorsyahbannie Mochamad , Sri Lestari Indah , Alwy Solehudin Muhammad , Enjelianto Ine
Published: July 2023

Advances in technology and information systems have had a major impact on people's lives and activities. Smartphone use plays an important role in many areas, including housing governance. One of the problems faced by housing administrators is administrative management, which is still manual. To overcome this, it is proposed to use a web-based application. A literature study was conducted to support the development of this application. Data collection through interviews and observations was carried out to obtain system requirements. The Agile Scrum method is used in making applications. These applications have non-functional requirements such as security, availability, performance, usability, and compatibility. Implementation using PHP and MySQL. Testing is done to ensure the application functions properly. This application allows administrators to manage citizen data, payment of contributions, billing, and print financial reports. Residents can upload proof of transfer and print proof of payment. It is hoped that this application will facilitate housing administration, improve the quality of life in the community, and create a better housing environment.
The Structural and Electrochemical Properties of CuCoO2 Crystalline Nanopowders and Thin Films: Conductivity Experimental Analysis and Insights from Density Functional Theory (DFT) Calculations
Authors: Chfii Hasnae , Bouich Amal , Andrio Andreu , Torres Joeluis Cerutti , Soucase Bernabé Mari , Palacios Pablo , Lefdil Mohammed Abd , Compañ Vicente
Published: July 2023

A novel manufacturing process is presented for producing Nano powders and thin films of CuCoO2 (CCO) material. This process utilizes three cost-effective synthesis methods: hydrothermal, sol-gel, and solid-state reactions. The resulting delafossite CuCoO2 samples were deposited onto transparent substrates through spray pyrolysis, forming innovative thin films with a Nano crystal powder structure. Prior to the transformation into thin films, CuCoO2 powder was first produced using a low-cost approach. The precursors for both powders and thin films were deposited onto glass surfaces using a spray pyrolysis process, and their characteristics were examined through X-ray diffraction, scanning electron microscopy, HR-TEM, UV-visible, and Electrochemical impedance spectroscopy (EIS) analyses was conducted to determine the conductivity in transversal direction of this groundbreaking material for solar cell applications. On the other hand, the sheet resistance of the samples was investigated using the four probe-method to obtain the sheet resistivity and them calculate the in plane conductivity of the samples. We also investigated the aging characteristics of different precursors with varying durations. The functional properties of CuCoO2 samples were explored by studying chelating agent and precursor solution aging periods. Resuming, this study thoroughly discusses the synthesis of delafossite powders and their conversion into thin films, which hold potential as hole transport layers in transparent optoelectronic devices.
Extracellular Vesicle microRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets
Authors: Tian Changhai , Ziegler Jessica N. , Zucker Irving
Published: July 2023

Extracellular vesicles (EVs) are emerging mediators of intracellular and inter-organ communications in cardiovascular diseases (CVDs), especially in the pathogenesis of heart failure through the transference of EV-containing bioactive substances. microRNAs (miRNAs) are contained in EV cargo and are involved in the progression of heart failure. Over the past several years, a growing body of evidence has suggested that the biogenesis of miRNAs and EVs are tightly regulated, and the sorting of miRNAs into EVs is highly selective and tightly controlled. Extracellular miRNAs, in particular circulating EV-miRNAs, have shown promising potential as prognostic and diagnostic biomarkers for heart failure and as therapeutic targets. In this review, we summarize the latest progress concerning the role of EV-miRNAs in HF and their application in a therapeutic strategy development for heart failure.
The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases
Authors: Kim Hee-Kyung , Oh Hye-Suk , Park Cheol-Hee
Published: July 2023

Background and Objectives: There is a need to effectively manage the healthy aging of the rapidly increasing number of elderly people in an ultra-elderly society. The purpose of this study was to analyze the mediating effects of social networks and wisdom on the relationship between lifestyle habits and healthy aging in older adults with chronic diseases. Materials and Methods: Participants were 120 community-dwelling older adults aged 65 and older with at least one chronic disease. Data were collected from elderly people who met the criteria by visiting nursing care worker training centers, senior centers, social gatherings, and home welfare centers in D, G, and S cities from May 24 to June 23, 2023, with a questionnaire consisting of lifestyle habits, social networks, wisdom and healthy aging, and general characteristics. Results: The degree of healthy aging of the subjects was 3.56 out of 5, and there were differences in the degree of healthy aging according to age (F=3.76, p=0.026), spousal relationship (t=3.11, p=0.002), education (F=9.08, p<0.001), number of diseases (F=8.65, p<0.001), and economic level (t=-2.45, p=0.016). The most common diseases among the subjects were hypertension, hyperlipidemia, joint diseases and diabetes mellitus. Healthy aging was highly correlated with lifestyle habits (r=0.63, p<0.001), social networks (r=0.65, p<0.001), and wisdom (r=0.73, p<0.001). Social networks (β=0.46, p<0.001) and wisdom (β=0.55, p<0.001) had partial mediating effects (z=4.15, p<0.001; z=5.11, p<0.001) on the relationship between subjects' lifestyle habits and healthy aging. Conclusions: In order to increase the degree of healthy aging of the subjects, it is necessary to establish a mediating intervention program that manages to have a good lifestyle habits in daily life, increase social networks, and become wise.
Generative Pre-Trained Transformers, Natural Language Processing and Artificial Intelligence and Machine Learning (AI/ML) in Software Vulnerability Management: automations in the Software Bill of Materials (SBOM) and the Vulnerability-Exploitability eXchange (VEX)
Authors: Radanliev Petar , De Roure David , Santos Omar
Published: July 2023

One of the most burning topics in cybersecurity in 2023 will undoubtedly be the compliance with the Software Bill of Materials. Since the US president issued the Executive Order 14028 on Improving the Nation’s Cybersecurity, software developers have prepared and bills are transmitted to vendors, customers, and users, but they don’t know what to do with the reports they are getting. In addition, since software developers have identified the values of the Software Bill of Materials, they have been using the reports extensively. This article presents an estimate of 270 million requests per month, just from form one popular tool to one vulnerability index. This number is expected to double every year and a half. This simple estimate explains the urgency for automating the process. We propose solutions based on artificial intelligence and machine learning, and we base our tools on the existing FAIR principles (Findable, Accessible, Interoperable, and Reusable). This methodology is supported with a case study research and Grounded theory, for categorising data into axis, and for verifying the values of the tools with experts in the field. We showcase how to create, and share Vulnerability Exploitability eXchange data, and automate the Software Bill of Materials compliance process with AI models and a unified computational framework combining solutions for the following problems: (1) the data utilisation problem, (2) the automation and scaling problem, (3) the naming problem, (4) the alignment problem, (5) the pedigree, and provenance problem, and many other problems that are on the top of mind for many security engineers at present. The uptake of these findings will depend on collaborations with government and industry, and on the availability and the ease of use of automated tools.
Atherogenic Dyslipidemia in Wistar Rats: Study of the Association of Fixed Oils from Abelmoschus esculentus (L.) Moench., Euterpe oleracea Martius., Bixa orellana Linné and Chronic SM®
Authors: Sales Priscila Faimann , NASCIMENTO ALINE LOPES DO , Pinheiro Fernanda Cavalcante , Alberto Andressa Ketelem Meireles , Teixeira dos Santos Abrahão Victor Tavares de Lima , Carvalho Helison de oliveira , De Souza Gisele Custódio , Carvalho And José Carlos Tavares
Published: July 2023

Dyslipidemia presents high levels of serum cholesterol, being characterized as a risk factor for cardiovascular diseases, especially for the development of atherosclerosis. E. oleracea (OFEO), A. esculentus (OFAE), B. orellana (OFBO) and granulated (CHR) oils are rich in bioactive compounds with potential to treat changes in lipid metabolism. This study investigated the effects of treatments with oils from A. esculentus, E. oleracea, B. orellana and granules (Chronic SM®) on saturated fat-induced dyslipidemia Cocos nucifera L. The chromatographic profile showed the majority of unsaturated fatty acids in the tested oils. The quantification of tocotrienols and geranylgeraniol was obtained in OFBO and CHR. Treatments with OFEO, OFAE, OFBO and CHR were able to significantly reduce glycemia with p>0.001, as well as hypertriglyceridemia, total cholesterol and LDL-cholesterol, in addition to increasing HDL-cholesterol. The treatments inhibited the formation of atheromatous plaques in the vascular endothelium of the treated rats. The obtained results suggest that the OFEO, OFAE, OFBO and CHR groups have antidyslipidemic effects and antiatherogenic activity.
A New Ultrafiltration-Based Process for Green Recovery of Polyphenols from Rose Petal By-Product
Authors: Dushkova Mariya , Vardakas Alexios , Shikov Vasil , Mihalev Kiril , Terzyiska Margarita
Published: July 2023

One main objective of this study was to increase the utilization of the raw material in the rose (Rosa damascena Mill.) essential oil industry by application of membrane technologies. A new ultrafiltration-based process for green recovery of polyphenols from distilled (de-aromatized) rose petals, the primary by-product in essential oil production, was created. The process includes enzyme-assisted extraction and subsequent membrane separation for partial concentration. Following a green membrane technology strategy, the newly developed process proposes an environmentally-friendly alternative to the conventional processing, comprising organic solvent ex-traction and adsorber resin purification. The results showed that the permeate flux decreased with volume reduction ratio’s rise and increased with the transmembrane pressure and feed flow rate rises. At the beginning of the process the highest flux was with UF1-PAN membrane, but at the end of the process with UF10-PAN membrane. Total polyphenols of the retentates in-creased by 27-39% and 26-67% during ultrafiltration with UF1-PAN and UF10-PAN membrane, respectively, with the highest value obtained for UF10-PAN membrane at VRR 6. The highest concentration factor and rejection of total solids, total polyphenols, redox-active antioxidants and radical scavenging antioxidants were obtained at VRR 6 with UF10-PAN membrane. This membrane and concentration level at transmembrane pressure of 0.4 MPa and feed flow rate of 330 dm3/h are recommended to be used for application of ultrafiltration of rose-petals by-product for potential use in the food industry.
Preparation and Mechanical Properties of Dolomite Dust-Emulsified Asphalt Composites
Authors: Liu Qun , Lin Weiqing , Zhou Fangyuan
Published: July 2023

The dolomite dust-emulsified asphalt composite with excellent mechanical properties was successfully prepared using alkali activation. The effects of different alkali concentrations and emulsified asphalt contents on the mechanical properties of the materials were studied. The mechanical properties and microstructure of the composites were analyzed using compressive strength tests, bending strength tests, and SEM characterization. The experimental results show that the specimens have excellent mechanical properties: the 7-day compressive strength can reach 76.67 MPa, and the bending strength is about twice that of silicate-based geopolymer-emulsified asphalt composite. With an increase in emulsified asphalt content, the compressive strength of the samples decreases, while the bending strength increases first and then decreases. When the emulsified asphalt content is 1%, the bending strength of the sample is up to 28.81 MPa, which is 25% higher than that of the sample without emulsified asphalt. This indicates that an appropriate emulsified asphalt content can play a toughening role in the system, providing a new idea for designing high-toughness alkali-activated materials.
Influence of Precipitation Conditions and Discharge Rates of River Estuary Barrages on Geomorphological Changes in an Estuarine Area
Authors: Kim Sung-bo , Kim Doo-pyo
Published: July 2023

Changes in coastal topography can affect the ecological environment and marine industries. In this study, we analyzed the patterns and causes of changes in shoreline and undersea topography in the Nakdong River estuary in the southeast of South Korea using depth and shoreline surveys of the estuary, as well as data on discharge, suspended sediments, and precipitation in the Nakdong River basin. The results showed that erosion and sedimentation occurred repeatedly owing to complex factors such as the discharge of the estuary and invasion by open sea waves. However, no clear unilateral trend was observed. Unlike previous survey data, a large amount of erosion occurred in the second half of 2020. Previously, sedimentation was the main process, but erosion occurred rapidly, which was observed in the summer of 2020 when the erosion was three times higher than that in other periods owing to the severe rainy season and torrential rains for over a month. In addition, regarding the flow rate and force of the river water outflow, the amount of discharge increased rapidly, causing erosion. Moreover, a strong typhoon in the summer of 2020 affected the topography of the estuary.
Moroccan Citrus clementina Peels: Optimization of Pectin Extraction, Chemical and Functional Properties
Authors: Azzouzi Hanane , Elhajji Loubna , Achchoub Mouad , Salmaoui Souad , Ammadi Abdelilah , Harrak Hasnaa , Touzani Rachid , Noutfia Younes , Kaoutar Elfazazi
Published: July 2023

Citrus peels are considered as a rich source of valuable biomolecules like pectin as polymer of polysaccharide acid. In this study, response surface methodology was used to optimize pectin extraction from Citrus clementina peels using citric acid as extraction solvent. The effect of parameters conditioning the extraction process and pectin yield (pH, temperature, extraction time, solid/liquid ratio, and raw material particle size) was investigated using a Box-Behnken design. The quality of the extracted pectin was assessed both chemically (moisture, ash, protein, and sugar content) and functionally (gelling power and emulsifying activity). According to the screening experiment, the factors pH, temperature, and particle size were the main factors influencing the pectin yield. The adjusted mathematical model enabled us to plot response surfaces in order to determine optimal extraction conditions. The highest production yield of pectin (26.6%) was obtained at the optimal conditions of: pH = 1.5; temperature 100 °C and particle size = 0.1 mm for an extraction time of 30min. Compared to the predicted value of 26.6%, the experimental extraction yield was about 21.4% of pectin. Concerning the functional properties, the extracted pectin has a high gelling power of 164°SAG and an emulsifying activity of 38.5%.
Development of Laser Cavitation Peening Using a Normal-Oscillation Nd:YAG Laser
Authors: Soyama Hitoshi
Published: July 2023

The impact induced by cavitation bubble collapse can be utilized for mechanical surface treatment to improve fatigue properties of metals including additive manufactured metallic materials. A peening method using cavitation impact induced by a pulsed laser is called “laser cavitation peening (LCP)”. Normally, a Q-switched Nd:YAG laser, whose pulse width is a few nanoseconds, is used for LCP, which improves the fatigue strength. The problem with LCP is that the processing time is too slow. If a laser pulse whose pulse width is a few hundred microseconds can be utilized for LCP, the repetition frequency can be increased drastically using other types of laser systems such as a fiber laser. In the present paper, in order to reveal the possibility of LCP using a pulsed laser width of a few hundred microseconds, the use of LCP with a normal-oscillation Nd:YAG laser (pulse width ≈ 200 us) was investigated. It is demonstrated that LCP with the normal-oscillation Nd:YAG laser produced curvature in an aluminum alloy plate.
Mitochondrial Redox Balance of Fibroblasts Exposed to Ti-6Al-4V Microplates Subjected to Different Types of Anodizing
Authors: Zalewska Anna , Antonowicz Bożena , Szulimowska Julita , Zieniewska-Siemieńczuk Izabela , Leśniewska Barbara , Borys Jan , Zieba Sara , Kostecka-Sochoń Paula , Żendzian-Piotrowska Małgorzata , Lo Giudice Roberto , Lo Giudice Giusseppe , Żukowski Piotr , Maciejczyk Mateusz
Published: July 2023

Despite the high biocompatibility of titanium and its alloys, the need to remove titanium implants is increasingly being debated due to the potential for adverse effects associated with long-term retention. Therefore, new solutions are being sought to enhance the biocompatibility of titanium implants. One of them is to increase the thickness of the passive layer of the implant made of titanium dioxide. We were the first to evaluate the effect of hard-anodized (type II) Ti-6Al-4V alloy discs on the cytotoxicity, mitochondrial function and redox balance of mitochondrial fibroblasts compared to standard-anodized (type III) and non-anodized discs. The study used fibroblasts obtained from human gingival tissue. The test discs were applied to the bottom of 12-well plates. Cells were cultured for 24h and 7; 14 and 21 days and mitochondria were isolated. We demonstrated the occurrence of oxidative stress in the mitochondria of fibroblasts of all tested groups, regardless of the presence and type of anodization. Type II anodization prevented changes in complex II activity (vs. control). The lowest degree of citrate synthase inhibition occurs in mitochondria exposed to titanium discs with type II anodization. In the last phase of culture, the presence of type II anodization reduces the degree of cytochrome c oxidase inhibition compared to the other tests groups and the control group, and prevents apoptosis. Throughout the experiment, the release of titanium, aluminium and vanadium ions from titanium discs with a hard-anodized passive layer was higher than from the other titanium discs, but decreased with time.
The obtained results prove the existence of dysfunction and redox balance in the mitochondria of fibroblasts exposed to hard-anodized titanium discs, suggesting the need to search for new materials perhaps biodegradable in tissues of the human body.
Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in Monocytic Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways
Authors: Akhter Nadeem , Wilson Ajit , Arefanian Hossein , Thomas Reeby , Kochumon Shihab , Al-Rashed Fatema , Al-Madhoun Ashraf , Al-Mulla Fahd , Ahmad Rasheed , Sindhu Sardar
Published: July 2023

Obesity and metabolic syndrome involve chronic low-grade inflammation called metabolic inflammation as well as metabolic derangements from increased endotoxin and free fatty acids. It is debated whether the endoplasmic reticulum (ER) stress in monocytic cells can contribute to amplify metabolic inflammation; if so, by which mechanism(s). To test this, metabolic stress was induced in THP-1 monocytic cells by treatments with lipopolysaccharide (LPS), palmitic acid (PA), or oleic acid (OA), in the presence or absence of ER stressor thapsigargin (TG). Gene expression of tumor necrosis factor (TNF)-α and markers of ER/oxidative stress was determined by qRT-PCR, TNF-α protein by ELISA, ROS by DCFH-DA assay, HIF-1α/p38/ERK-1,2/NF-κB phosphorylation by immunoblotting, and insulin sensitivity by glucose-uptake assay. Regarding clinical analyses, adipose TNF-α was assessed by qRT-PCR/IHC and plasma TNF-α/hs-CRP/MDA/OX-LDL by ELISA. We found that the cooperative interaction between metabolic and ER stresses promoted TNF-α, ROS, CHOP, ATF6, SOD2, and NRF2 expression (P≤0.0183),. However, glucose uptake was not impaired. TNF-α amplification was dependent on HIF-1α/p38/NF-κB phosphorylation, while MAPK/NF-κB inhibitors and antioxidants/ROS scavengers attenuated TNF-α production (P≤0.05). Individuals with obesity displayed increased adipose TNF-α gene/protein expression as well as elevated plasma levels of TNF-α, CRP, MDA, and OX-LDL (P≤0.05). Our findings support a cooperative interaction between metabolic and ER stresses, favoring inflammation by triggering TNF-α production via the ROS/CHOP/HIF-1α and MAPK/NF-κB dependent mechanisms. This study also shows the therapeutic potential of ROS scavengers/anti-oxidants in inflammatory conditions involving metabolic/ER stresses.
Extensive Validation of a New Rock Breakage Test
Authors: De Paiva Bueno Marcos , Almeida Thiago , Powell Malcolm S.
Published: July 2023

Comminution is the most power-demanding stage, and the lack of geometallurgical testing, often for financial reasons, may result in an inefficient operation. The Geopyörä Rock Breakage test was developed with the objective of making mineral variability data more accessible by providing both standard comminution parameters and rock mechanical properties at low cost, and with a modest sample size, allowing a larger number of samples to be tested to reduce uncertainties and assure productivity. The objective of this work is to present the results of an extensive validation of this new rock breakage method against two of the main tests currently in use, namely the SMC® and Bond ball mill work index tests. More than 100 samples have been tested and the results compared, showing that the new method can accurately estimate the parameters of the traditional tests. This confirms that the new test is a reliable tool for comminution and geometallurgical tests.
Anesthetic Management for a Pregnant Patient with Bilateral Vocal Cord Granuloma Using High-Flow Nasal Cannula Oxygenation with Oxygen Reserve Index Monitoring: A Case Report
Authors: Kim Hyo Sung , Oh Seok Kyeong , Lee Jae Eun , Lee Hyun Ah , Cho Jae-Gu
Published: July 2023

Anesthetic management for pregnant suffering from airway pathology poses unique challenges. The presence of bilateral vocal cord granuloma adds further complexity to the management, as it can potentially cause airway compromise and respiratory distress. This case presents a pregnant patient with bilateral vocal cord granuloma who underwent anesthesia using high-flow nasal cannula (HFNC) oxygenation and oxygen reserve index (ORi) monitoring. A 33-year-old pregnant woman, who had undergone intubation six month ago, experienced hoarseness and was ultimately diagnosed with bilateral granuloma. Due to the significant airway obstruction, neither intubation nor ventilation was feasible, thereby requiring a surgical intervention. Before the surgical removal, the patient’s oxygenation was ensured using HFNC oxygenation. After confirming sufficient oxygenation of the patient with ORi of 0.38, the operation commenced and as it lasted approximately 3 minutes, the patient was able to tolerate the brief period without additional oxygen supply. Post-surgical excision, mask bagging and HFNC oxygenation was resumed, driving ORi to 0.39, then the operation was resumed. Throughout the procedure, SpO2 remained above 98. The combination of HFNC and ORi ensured adequate oxygenation and allowed for early detection of hypoxemia during the procedure. This approach may be a good option for managing granuloma.