bluuebunny/crossref_metadata_2025 huggingface dataset:
Arte no Bairro dos Pimentas
Authors: Caldeira de Farias Junior Orlando , Dos Santos Oliveira Ellen Cristina
Published: December 2024

O trabalho consiste em uma coleta de imagens com manifestações de cosmo percepções no Bairro dos Pimentas. Procuramos, arrimados na Geografia e Semiótica, manifestações de fé nos muros do distrito guarulhense. De avenidas movimentadas às ruas com pouco movimento, o trabalho selecionou imagens oriundas tanto da pichação quanto do grafite, à qual procuramos com elas exibir essa sui generis forma de levar a cosmo percepção à transeuntes locais e das adjacências.
Apresentação
Authors: FGV/CPDOC Revista Mosaico , Sampaio Alves Maria Eduarda
Published: December 2024

A cada edição propomos um dossiê, que é fruto dessa construção coletiva. Nas últimas edições, valorizamos os entendimentos sobre o Brasil e suas formas particulares de expressão e identificação. No sexagésimo aniversário do Golpe Cívico-Militar, a Revista Mosaico propõe como dossiê perceber as relações entre cultura, política e história, desde o pós-1964 até os dias atuais, a fim de elucidar como as interpretações históricas podem ser moldadas por interesses políticos e ideológicos no tempo presente.
Profesor Adam Wrzosek (1875-1965) jako założyciel i redaktor „Archiwum Historii i Filozofii Medycyny”
Authors: Musielak Michał
Published: December 2024

Profesor Adam Wrzosek należy do grona najwybitniejszych polskich historyków i filozofów medycyny. Przyczynił się nie tylko do utworzenia Wydziału Lekarskiego na Uniwersytecie Poznańskim, ale również zbudował podwaliny medycyny akademickiej w Wielkopolsce. Jednym z jego największych osiągnięć na polu historii i filozofii medycyny było założenie i redagowanie czasopisma „Archiwum Historii i Filozofii Medycyny”, którego był redaktorem nieprzerwanie od 1924 do 1947 r. Celem artykułu jest ukazanie motywów powołania do życia czasopisma, a także charakterystyka zakresu poruszanych na jego łamach problemów i zagadnień.
Tango: An Introduction To Tango-related Topics
Authors: Stala Ewa
Published: December 2024

The aim of this article is to present tango not as a choreographic arrangement (although this will inevitably be discussed), but as a social phenomenon with a very interesting history, created in specific historical and cultural circumstances, constituting an extremely popular cinematic and literary motif and, no less importantly, an area of linguistic research. Hence the more general or descriptive nature of the article, in which, in addition to the necessary information, numerous questions, doubts and research paths appear. At the same time, we would like to emphasize the international and intercultural nature of tango, visible primarily in music and dance, but also in all the other threads presented in this article, which makes this dance a subject of broadly understood cultural studies.
Flamenco Dance Academies in Seville – a Transcultural Exchange Field
Authors: Romanowska Jadwiga
Published: December 2024

The objective of this text is to present flamenco dance academies in Seville as a field of transcultural exchange. The theoretical framework is provided by two concepts: Wolfgang Welsch’s idea of transculturality and Francisco Aix Gracia’s concept of the ‘flamenco field’ (campo flamenco). Flamenco dance academies serve functions that extend well beyond the mere execution of dance instructions – they are institutions where individuals from diverse cultural backgrounds, including foreigners, Andalusians, Andalusian Roma, and Spaniards from outside Andalusia, interact and negotiate their cultural identity. Flamenco dance schools also may be considered as transcultural platforms for the renegotiation of elements integral to the identities of foreign dancers, including lifestyle, behaviour, language, body, movement, and expression.
Effects of a Internet-Based Cognitive Behavioral Therapy Program for Adolescents with Diabulimia: A Randomized Controlled Trial
Authors: Park Hye-Ryeon , Ju Hyeon Ok
Published: December 2024

Purpose: Diabulimia is a serious problem that can cause a variety of complications in adolescents with type 1 diabetes. The purpose of this study was to evaluate the effectiveness of Internet-based cognitive behavioral therapy program for adolescents with diabulimia.Methods: A randomized controlled trial was conducted on 38 adolescents aged between 13 and 18 years with type 1 diabetes who scored 20 or higher on the Diabetes Eating Problem SurveyRevised (DEPS-R). The experimental group received eight sessions of an Internet-based cognitive behavioral therapy.Results: Immediately after the intervention and four weeks later, the experimental group demonstrated significant reductions in automatic thoughts, depression,and diabetic eating disorder behavior with an increase in body satisfaction compared to the control group.Conclusion: The Internet-based cognitive behavioral therapy for adolescents with diabulimia used various techniques to find dysfunctional thoughts that could induce negative emotions and behaviors based on actual experience. When delivered via the Internet, it provided participants with unrestricted access in terms of both time and location.
Coaching in Nursing: A Concept Analysis
Authors: Lee Seo Yeon , Han Kuem Sun , Jung Miran
Published: December 2024

Purpose: This study aimed to define coaching in nursing clearly and elucidate its essential role within the context of contemporary nursing education in clinical settings.Methods: A concept analysis was conducted using Rodgers’ evolutionary method. Literature was extracted from databases such as Web of Science, Medline (PubMed) and CINAHL.Results: Results of analysis led to the development of an operational definition of coaching in nursing characterized as an educational approach focusing on nursing tasks. Coaching in nursing is a systematic and formalized process that can enhance the learning experience through interactive engagement rather than direct instruction. The analysis identified five core attributes of coaching in nursing: nursing task-focused, educational, facilitative, processive, and interactive.Conclusion: The purpose of this concept analysis was to propose a comprehensive definition of coaching in nursing that could align with its theoretical foundation within modern nursing practice. Using Rodgers' evolutionary concept analysis method, related terms, attributes, antecedents, and outcomes were identified, culminating in a detailed definition. This concept analysis provides a contemporary definition of coaching in nursing, clarifying its meaning, ensuring applicability, and offering guidance for future research, education, and clinical practice.
Development and Effectiveness of a Foot Care Program for Patients with Schizophrenia Hospitalized During Psychiatric Care: A Mixed-Methods Study
Authors: Jeong Min Ji , An Hyo Ja
Published: December 2024

Purpose: To determine the effects of a foot care program on hospitalization stress, self-esteem, and self-care agency for patients with schizophrenia in a closed psychiatric ward.Methods: An embedded mixed-method design was used, applying a non-equivalent control group pre-post design and qualitative content analysis. Participants were 25 patients with schizophrenia in a closed ward (experimental group: 13, control group: 12). The foot care program was conducted 12 times over 4 weeks. Data were collected from June 5, 2023, to September 29, 2023.Results: Study results revealed that the foot care program was effective in reducing hospitalization stress (Z=-2.75, p=.006), increasing self-esteem (Z=-3.99, p<.001), and improving self-care agency (Z=-2.89, p=.003) for hospitalized patients with schizophrenia. Qualitative analysis identified 3 main categories and 9 subcategories related to the program participation experience.Conclusion: Results of this study suggest that a foot care program can be an effective mental health nursing intervention to reduce hospitalization stress and improve self-esteem and self-care agency in hospitalized patients with schizophrenia.
Predictors of Suicidal Behavior in Young Adults: An Analysis of Korea National Health and Nutrition Examination Survey Data Using Propensity Score Matching
Authors: Lee Young Hwa , Hwang Seon Young
Published: December 2024

Purpose: To compare sociodemographic and health-related characteristics of individuals at risk of suicidal behavior and those of non-risk individuals through propensity score matching (PSM) and to identify predictive factors influencing suicidal behavior.Methods: A secondary analysis was performed using data from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2013 to 2021. Among young adults aged 19 to 34 years, individuals at risk of suicidal behavior and non-risk individuals were matched at a 1:4 ratio using the R program for PSM. x2 analysis and logistic regression analysis were performed using SPSS.Results: Significant differences were found in current smoking, two-week physical illness, depression diagnosis, subjective health status, two-week depressive mood, and perceived stress. Factors influencing suicidal behavior included two-week depressive mood, depression diagnosis, subjective health status, and perceived stress.Conclusion: This study emphasizes the need to manage depressive mood to prevent suicidal behavior. Additionally, it suggests that preventive education programs should be provided according to subjective health status and opportunities to participate in stress management programs.
Mental Health Condition of Adolescents to Early Adulthood: A Study of Indonesian College Students
Authors: Zainafree Intan , Maharani Chatila , Rasyad Ula Faza Nayli , Wahyuningsih A Setyo , Hermawati Bertakalswa , Putra Tyar Bhatara , Khasanah Amelia Fitra , Syukria Nadia , Saefurrohim Muhammad Zakki , Hakam Abdul , Zaimatuddunia Irma , Amrita  , Prasetya Henky Yoga , Sopha Kasihana Hismanita , Pandanwangi Syarifah Rose , Wigatie Ragil Ayu , Mofu Ana Safira Susanti , Susanti Iis , Simanullang Audrey Najwa Bahary , Fadzilaturrahman Muhammad Arief
Published: December 2024

Purpose: To detect the mental health conditions of students and identify factors influencing their reluctance to seek psychological help in order to prevent progression of more serious mental health issues.Methods: This study had a quantitative descriptive survey design. Participants were adolescent active undergraduate students aged 18-24 years. Data were collected through an online questionnaire comprising Indonesian versions of the Mental Health Inventory (MHI-38) and Health Seeking Behavior assessments. Statistical analyses were conducted using IBM SPSS 25 to evaluate respondent characteristics and mental health conditions.Results: We found that psychological wellbeing declined with age, with older people being more susceptible to depression and emotional loss than younger people. Men had higher levels of anxiety, depression, and emotional loss than women. Migrant individuals had lower wellbeing than non-migrants. Close friends were the most common source for seeking mental health support, reflecting a preference for informal help rather than professional help.Conclusion: Transition from adolescence to adulthood is associated with heightened mental health vulnerabilities, especially among first-year male students. Thus, innovative mental health education and peer counseling are needed to better support their psychological well-being.
Harnessing Probiotics and Prebiotics for the Prophylaxis and Treatment of Bacterial Vaginosis
Authors: A R Nayana , T R Keerthi
Published: December 2024

ABSTRACT: Bacterial vaginosis (BV) is the prevalent condition of reproductive-age women in the general population. BV increases the risk of miscarriage, low birth weight, preterm birth, pelvic inflammation, sexually transmitted diseases, etc. Generally, antibiotics like metronidazole and clindamycin were used for the treatment of this recurrent infection. The use of antibiotics only gives temporal relief and may cause serious conditions of antibiotic resistance, and they kill a wide range of beneficial vaginal microbes. Hence alternative treatment methods like the use of probiotics and prebiotics for the prevention of bacterial vaginosis and other bacterial infections will be more effective. They help to optimize, maintain, and restore the vaginal acidic environment and eubiosis of the vaginal ecosystem. The current review focuses on the role of probiotics and prebiotics and the combined effect of both for the treatment and prophylaxis of bacterial vaginosis and other bacterial infections. Also, the review emphasizes the understanding of the role of vaginal microbiome in modulating the health of women and as a promising solution for recurrent vaginal infections.
In-Depth Look into Genetic Influences on Postural Orthostatic Tachycardia Syndrome and Ehlers-Danlos Syndrome: A Comprehensive Review
Authors: Sundarrajan Mouliprabakaran , Ravichandran Venkatesaprasath , Ramachandran Revanth
Published: December 2024

ABSTRACT: Postural Orthostatic Tachycardia Syndrome (POTS) is a prevalent but underrecognized cardiovascular autonomic disorder characterized by an excessive heart rate increase upon standing and symptoms of orthostatic intolerance. Predominantly affecting women aged 15–45, POTS can be debilitating and economically burdensome, particularly impacting young adults in their prime educational and professional years. The etiology of POTS remains elusive, with both genetic and non-genetic factors, such as trauma, infections, and pregnancy, potentially contributing. Genetic mutations have been implicated,particularly in the norepinephrine transporter (NET) gene. NET plays a critical role in norepinephrine reuptake, and its dysfunction can lead to heightened sympathetic nervous system activity, contributing to POTS symptoms. Specific polymorphisms, like rs7194256 in the NET gene, have been linked to impaired norepinephrine clearance and increased sympathetic activity. Epigenetic modifications and regulatory mechanisms involving transcription factors and microRNAs also influence NET gene expression. Additionally, conditions like Ehlers-Danlos Syndrome (EDS) often coexist with POTS, suggesting a complex interplay between connective tissue disorders and autonomic dysfunction. While the genetic basis of POTS, including the role of NET gene variations, is not fully understood, preliminary evidence suggests these variations may affect norepinephrine modulation and autonomic function. Further research with larger, more diverse cohorts and advanced genetic analyses is needed to elucidate the mechanisms by which NET gene variations contribute to POTS. Understanding these mechanisms could improve diagnostic and therapeutic strategies, ultimately enhancing patient outcomes.
Innovative Biodegradable Polymer Hydrogel Beads for Enhanced Controlled Drug Delivery: Formulation and Characterization
Authors: Singh Pawan , Raj Keshav , Shrivastav Alankar , Sharma Vijay
Published: December 2024

ABSTRACT: To address this, our research pioneers the development of Cefixime-loaded controlled-release hydrogel beads using biodegradable polymers, an innovative approach designed to optimize antibiotic delivery and combat resistance. This study's novelty lies in utilizing chitosan, a natural, biocompatible polymer, for sustained drug release in the gastric environment. The hydrogel beads were engineered through ionic gelation, with tripolyphosphate (TPP) acting as the crosslinking agent, allowing for a stable, controlled release formulation. Key analyses included FTIR spectroscopy for structural confirmation, drug entrapment efficiency (DEE) for measuring Cefixime retention, and in vitro release studies to assess the extended-release profile. This research contributes to the field of controlled drug delivery systems by offering a practical solution to prolong antibiotic efficacy, particularly in regions facing high rates of bacterial resistance. The application of such a system could revolutionize treatment strategies, minimizing resistance development while ensuring effective drug levels over extended periods. The entrapment efficiency of hydrogel beads with Cefixime trihydrate ranged from 92.17±0.92% to 61.82±0.45%. Among all formulations, F3 demonstrated sufficient drug release in vitro. Kinetic analysis revealed that all formulations had an n (release exponent) value greater than 1, indicating super Case II transport, in which the swelling and erosion of the polymer matrix controlled the drug release rate.
Antimicrobial and Larvicidal Efficacy of the Methanolic Extract of Spinifex littoreus (Burm F.) Merr.
Authors: Nallaiyah Vedhamani John , Newton Paul Ajithkumar Issac
Published: December 2024

ABSTRACT: The increasing drug resistance of microbial populations is driving researchers to discover novel antimicrobial agents. Plants are the major reservoir of secondary metabolites which are capable of fighting against microorganisms. The current study focused on identifying a potent antimicrobial and larvicidal agent from the coastal plant Spinifex littoreus (Burm f.) Merr. The leaves of S. littoreus were extracted with methanol and used for further analysis. The antimicrobial assay of the methanolic extract of S. littoreus (SL-M) was conducted by agar well diffusion method for 6 bacterial (Escherichia coli, Propionibacterium acnes, Staphylococcus aureus, Aeromonas hydrophila, Streptococcus faecalis, Bacteroids fragilis) and 4 fungal (Cryptococcus neoformans, Aspergillus fumigatus, Aspergillus niger, Sporothrix schenckii) strains. Nutrient agar and Potato dextrose agar medium were used respectively, and different SL-M extracts were introduced. After incubation, the zone of inhibition was calculated. As for the larvicidal bioassay, the larvae of Aedes aegypti were grown in distilled water and they were treated with different concentrations of SL-M extracts. After 24 hours of incubation, larval mortality rate and LC50 values were calculated. The antimicrobial assay revealed that P. acnes and C. neoformans showed maximum inhibition than the other tested strains. The SL-M extract showed dose-dependent activity against larvae of Ae. aegypti. And the predicted LC50 value is 67.058 ppm. Considering the results of this current research the methanolic extract of S. littoreus can be an alternative source of antibiotics as well as a potent mosquito larval repellent.
Spinal Gout: A Comprehensive Review of Clinical Features, Diagnostic Challenges, and Management Strategies in Spinal Gout
Authors:   Department of Orthopaedics, D.Y Patil School of Medicine and Hospital, Navi Mumbai, Maharashtra, India,, Kale Sachin , Vatkar Arvind ,   Department of Orthopaedics, MGM Medical College, Navi Mumbai, Maharashtra, India,, Dhar Sanjay ,   Department of Orthopaedics, D.Y Patil School of Medicine and Hospital, Navi Mumbai, Maharashtra, India,, Bhor Pramod ,   Department of Orthopaedics, Fortis Hiranandani Hospital, Mumbai, Maharashtra, India,, Phadnis Ashish ,   Department of Orthopaedics, Jupiter Hospital, Thane, Maharashtra, India., Samant Prakash ,   Department of Orthopaedics, D.Y Patil School of Medicine and Hospital, Navi Mumbai, Maharashtra, India,, Mehra Shivam ,   [5] Mehra Hospital and Research Institute, Lucknow, Uttar Pradesh, India,
Published: December 2024

Spinal gout is an uncommon form of gout that is distinguished by the deposition of monosodium urate (MSU) crystals in the spine, resulting in severe pain and potential neurological impairments. Despite its rarity, spinal gout can be difficult to diagnose because of its vague symptoms and similarities to other spinal illnesses. This study delves into the epidemiology, clinical aspects, and diagnostic problems of spinal gout, focusing on the Indian setting. Diagnostic methods such as X-ray, computed tomography (CT), and magnetic resonance imaging are investigated, with a focus on dual-energy CT for identifying MSU deposits. The treatment options vary from conservative maintenance with non-steroidal anti-inflammatory drugs and urate-lowering medication to surgical intervention in situations of neurological damage.
Keywords: Spinal gout, tophaceous gout, lumbar spine, diagnostic challenges, hyperuricemia.
An Observational Study of Clinical, Radiological, and Functional Outcome in Tibial Plateau Fractures Operated with Open Reduction Internal Fixation in Adults
Authors:   Department of Orthopaedics, Jupiter Hospital – Eastern Express Highway, Thane, Mumbai, Maharashtra, India, Jadhao Piyush Madhukar , Phadnis Ashish ,   Department of Orthopaedics, Jupiter Hospital – Eastern Express Highway, Thane, Mumbai, Maharashtra, India
Published: December 2024

Background: Tibial plateau fractures are among some of the most challenging fractures to treat, associated with a high incidence of posttraumatic osteoarthritis later in life. The most commonly used surgical treatment is open reduction and fixation (ORIF) with plates and screws.
Objectives: This study was conducted to determine the radiological, clinical, and functional outcomes of patients with tibial plateau fractures treated by ORIF.
Materials and Methods: This retroprospective observational study included adult patients operated on for tibial plateau fractures using ORIF. Functional outcome was assessed by patient-reported outcome measures using Short Musculoskeletal Function Assessment, Knee Injury and Osteoarthritis Outcome Score (KOOS), and Short Form-36 Quality of Life questionnaires. Clinical and radiological outcomes were assessed using Modified Rasmussen’s clinical and radiological criteria.
Results: The majority of our patients had type 6 fractures (43.59%). We found a statistically significant negative correlation between the type of fracture and the KOOS total score. Clinical assessment using the Modified Rasmussen Criteria showed excellent results in 33.33% of patients, good results in 51.28% of patients, and fair and poor results in 7.69% of patients each, with an overall satisfactory clinical result in 84.61% of patients. The radiological assessment noted excellent results in 23.08% of patients, good results in 56.41% of patients, fair results in 12.82% of patients, and poor results in 7.69% of patients.
Conclusions: The preferred treatment of choice for tibial plateau fractures is open reduction internal fixation, with most patients demonstrating satisfactory (excellent to good) clinical and radiological outcomes. Operatively treated tibial plateau fractures result in improved functional outcomes, as it offers excellent anatomical reduction and rigid fixation to restore early movement and articular congruity, in addition to preventing stiffness of the knee.
Keywords: Proximal tibia fracture, ORIF, Quality of life, functional outcome, KOOS, SF-36, SMFA.
Atypical Presentation of Gout: Idiopathic Retrocalcaneal Pain in 400 Patients
Authors:   Mehra Hospital and Research Institute, Lucknow, Uttar Pradesh, India,, Mehra Shivam , Mehra Nindiya Kapoor ,   Mehra Hospital and Research Institute, Lucknow, Uttar Pradesh, India,, Vatkar Arvind J. ,   MGM Medical College, Nerul, Navi Mumbai, Maharashtra, India,, Mehra Kamal ,   Mehra Hospital and Research Institute, Lucknow, Uttar Pradesh, India,, Manchanda Bharat Veer ,   Arthritis and Breast Care Centre, Kurukshetra, Haryana, India,, Kale Sachin ,   Department of Orthopaedics, Dr D Y Patil School of Medicine, Nerul, Navi Mumbai, India
Published: December 2024

Introduction: Idiopathic retrocalcaneal pain is frequently linked to overuse injuries or inflammation around the Achilles tendon and surrounding bursae. However, systemic conditions such as gout, characterized by monosodium urate crystal deposition, can also present as retrocalcaneal pain. Gout commonly affects the first metatarsophalangeal joint, but atypical presentations like retrocalcaneal involvement are increasingly recognized. This study aims to assess the presentation, diagnosis, and treatment outcomes of gout in patients presenting with idiopathic retrocalcaneal pain.
Materials and Methods: This retrospective study analysed clinical data from 400 patients diagnosed with gout and presenting with idiopathic retrocalcaneal pain between 2019 and 2023 at a tertiary care centre. Diagnosis was based on clinical examination, serum uric acid levels, imaging, and in some cases, synovial fluid analysis. Patient demographics, diagnostic methods, and treatment outcomes, including pain (VAS) and functionality (FADI) scores, were evaluated.
Results: Of the 400 patients, 290 (72.5%) were male, and 110 (27.5%) were female, with a mean age of 56.8 ± 12.3 years. Pre-existing gout was present in 58% of patients, and serum uric acid levels were elevated in 75%. Synovial fluid analysis, performed in 65 patients, confirmed monosodium urate crystals in 92.3% of cases. Treatment resulted in significant reductions in pain (VAS: 7.8 ± 1.4 to 3.2 ± 1.1, p < 0.05) and improved functionality (FADI: 58.4 ± 5.7 to 85.7 ± 6.3). Recurrence of symptoms occurred in 25% of patients, particularly in those who did not adhere to urate-lowering therapy.
Conclusion: This study emphasizes the importance of considering gout in the differential diagnosis of idiopathic retrocalcaneal pain. Early diagnosis and appropriate management can lead to favourable outcomes and lower recurrence rates. Clinicians should remain vigilant for atypical presentations of gout to prevent prolonged discomfort and functional impairment.
Keywords: Idiopathic retrocalcaneal pain, gout, hyperuricemia, monosodium urate crystals, Achilles tendon, atypical gout, urate-lowering therapy
The Promise of Kinematic Alignment in TKA: Game-changer or Gimmick?
Authors:   Department of Orthopaedics, Hip and Knee Arthroplasty Unit, SAANVI Orthopaedics, Mumbai, Maharashtra, India., Nighot Abhishek , Virkar Niharika ,   Department of Hand and Microsurgery, Pinnacle Hospital, Thane, Maharashtra, India.
Published: December 2024

Introduction: Total knee arthroplasty (TKA) is a proven solution for end-stage knee arthritis, yet traditional mechanical alignment (MA), which aims for a neutral mechanical axis, leaves up to 20% of patients dissatisfied postoperatively. Kinematic alignment (KA) has emerged as an alternative, focusing on restoring the patient’s native anatomy and joint line orientation, achieving balance without extensive soft-tissue releases.
Methods: This article examines the principles of KA and compares it with MA regarding safety, outcomes, and biomechanical balance through a literature review comprising various retrospective studies, randomized controlled trials, and systemic reviews. KA relies on the patient’s unique femoral morphology to guide bone cuts, achieving natural alignment and ligament balance. Evidence suggests that KA offers comparable if not superior, functional outcomes, with higher Oxford knee scores and forgotten joint scores while maintaining similar implant survivorship. Studies also show KA leads to better compartmental balance, reduced knee adduction moments, and more natural gait mechanics. The compartmental pressure alignment knee classification highlights KA’s ability to balance the knee across various lower limb phenotypes.
Conclusion: Although KA shows promise, challenges remain. Concerns about tibial varus have been addressed, with studies confirming no compromise in implant stability or survival. However, long-term data are needed to validate KA’s durability and define its role for specific patient groups.
This article provides a comprehensive overview of KA’s benefits and limitations, offering guidance for surgeons seeking evidence-based alignment strategies. It underscores KA’s potential as a personalized approach in TKA, bridging gaps in satisfaction and functional outcomes while maintaining safety.
Keywords: Kinematic alignment, mechanical alignment, arthroplasty, osteoarthritis.
Musculoskeletal Tissue Retrieval from Deceased Donors in India: Protocols and Challenges
Authors:   Novo Tissue Bank and Research Centre, Mumbai, Maharashtra, India., Shah Damini , Bhagunde Prasad ,   [2] Department of Orthopaedics, Sona Medical Centre, Mumbai, Maharashtra, India. [3] Department of Orthopaedics, Saifee Hospital, Mumbai, Maharashtra, India. [4] Department of Orthopaedics, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India. [5] Department of Orthopaedics, Breach Candy Hospital Trust, Mumbai, Maharashtra, India., Modi Nihar ,   [2] Department of Orthopaedics, Sona Medical Centre, Mumbai, Maharashtra, India [4] Department of Orthopaedics, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India. [6] Department of Orthopaedics, Criticare Asia Multispeciality Hospital and Research Centre, Mumbai, Maharashtra, India.
Published: December 2024

Musculoskeletal tissue donation from deceased donors plays a crucial role in advancing orthopedic and reconstructive surgeries, providing an alternative to autografts and synthetic implants. Despite its clinical significance, the adoption of tissue donation in India remains limited due to challenges such as low public awareness, cultural barriers, and infrastructural constraints. This study analyzes 16 cases of musculoskeletal tissue retrieval conducted in Mumbai between 2022 and 2023, highlighting procedural protocols, ethical considerations, and logistical challenges. The analysis underscores the importance of timely retrieval, adherence to regulatory frameworks like the Transplantation of Human Organs and Tissues Act (THOTA) 1994, and stringent quality assurance measures to ensure the safety and efficacy of allografts. Results demonstrate a high success rate, with over 98% of retrieved tissues meeting bioburden and structural integrity standards. The paper advocates for standardized protocols, improved public awareness, and enhanced training for healthcare professionals to advance tissue donation practices in India. This effort is pivotal for addressing unmet medical needs and fostering a compassionate healthcare system.
Keywords: Allografts, Musculoskeletal tissue donation, Tissue Banking, Orthobiologics, Reconstructive surgeries
Non-detection of emerging and re-emerging pathogens in wastewater surveillance to confirm absence of transmission risk: A case study of polio in New York
Authors: Larsen David A. , Hill Dustin , Zhu Yifan , Alazawi Mohammed , Chatila Dana , Dunham Christopher , Faruolo Catherine , Ferro Brandon , Godinez Alejandro , Hanson Brianna , Insaf Tabassum , Lang Dan , Neigel Dana , Neyra Milagros , Pulido Nicole , Wilder Max , Yang Nan , Kmush Brittany , Green Hyatt
Published: December 2024

Infectious disease surveillance systems, including wastewater surveillance, can alert communities to the threat of emerging pathogens. We need methods to infer understanding of transmission dynamics from non-detection. We estimate a sensitivity of detection of poliovirus in wastewater to inform the sensitivity of wastewater surveillance for poliovirus using both a clinical epidemiology and fecal shedding approach. We then apply freedom from disease to estimate the sensitivity of the wastewater surveillance network. Estimated sensitivity to detect a single poliovirus infection was low, <11% at most wastewater treatment plants and <3% in most counties. However, the maximum threshold for the number of infections when polio is not detected in wastewater was much lower. Prospective wastewater surveillance can confirm the absence of a polio threat and be escalated in the case of poliovirus detection. These methods can be applied to any emerging or re-emerging pathogen, and improve understanding from wastewater surveillance.
How have Ontario Public Health units engaged with faith-based organizations to build confidence in COVID-19 vaccines among ethno-racial communities
Authors: Kadio Kadidiatou , Song Melodie Yunju , Karbasi Anna , Blake-Hepburn Denessia , Fadel Shaza A. , Allin Sara , Ataullahjan Anushka , Di Ruggiero Erica
Published: December 2024

In Ontario, collaborations between Public Health Units (PHUs) and faith-based organizations (FBOs) and other community organizations were implemented to deliver interventions aimed at building trust in vaccines among ethnoracial communities. This research sought to explore the processes of PHU engagement with FBOs, and challenges encountered. A qualitative research study based on in-depth interviews was conducted with 18 of the 34 Ontario PHUs who expressed an interest. Braun and Clarke’s "experiential" approach was used to explore the realities of PHUs’ contextual experiences and perspectives. PHUs developed a two-phased process for engaging with FBOs and ethnoracial communities. First, PHUs created internal frameworks for dialogue to use available data to better understand the diverse needs of these equity-seeking groups. The second phase involved a three-stage engagement process:1) Consultation and information sharing was employed to facilitate early and open dialogue. 2) Work with FBOs and interested communities to plan vaccine deployment strategies to meet the needs of different faith and ethno-racial groups, and jointly plan the implementation of vaccination clinics. 3) Share roles and responsibilities with FBOs to roll out vaccine confidence strategies. The PHUs’ openness to honest dialogue with FBOs, commitment to building relationships based on respect for different beliefs and opinions about vaccines, and previous experience working together all facilitated engagement. Lessons learned from this research can guide the implementation of future vaccination programs. Ensuring early and regular engagement with FBOs a priority strategy and devoting substantial resources (human, financial and duration) are both necessary to improve vaccine confidence and promote equity for ethno-racial groups.
Factors associated with retention and adherence on Pre-Exposure Prophylaxis among men who have sex with men in Kigali, Rwanda
Authors: Mubezi Sezi , Malamba Samuel S. , Rwibasira Gallican N. , Uwineza Jeanne , Kayisinga Jean de Dieu , Remera Eric , Ikuzo Basile , Ndengo Emah , Umuhoza Nadege , Sangwayire Beata , Mwesigwa Richard C. N. , Stamatakis Caroline E. , Wandera Manasseh G. , Oluoch Tom O. , Kayirangwa Eugenie
Published: December 2024

Pre-Exposure Prophylaxis (PrEP) is recommended as an HIV prevention measure for men who have sex with men (MSM). We assessed factors associated with PrEP retention and adherence among MSM in Kigali, Rwanda. We undertook a retrospective cross-sectional study and used a questionnaire to obtain PrEP retention and adherence history from MSM enrolled in the key population (KP) program that attended scheduled follow-up clinics from four (4) health facilities between April 2021 to June 2021. Retention was defined as attending scheduled PrEP follow-up appointments and adherence as taking PrEP medication 95% or more of the time. We used multivariable cox proportion hazard regression to determine factors associated with 3-month retention and principal component analysis (PCA) to determine factors associated with self-reported adherence. Data were analyzed using STATA (version 16.0). We interviewed 439 MSM aged 18 years and above that were initiated on PrEP. Majority were employed (57%, n = 251), between ages 25–34 years (49%, n = 217), close to half completed primary level education (47%, n = 206), were involved in sex work (42%, n = 184), and over a half lived in household of 1–2 members (55%, n = 241). Ninety percent of the MSM respondents (n = 393) were retained on PrEP at 3 months and among those retained, 287 (73%) had good adherence. Multivariable cox regression revealed that MSM more likely to be retained on PrEP, were those that are sex workers (adjusted Hazard Ratio (aHR) = 4.139; 95% Confidence Interval (95%CI): 1.569, 10.921), had more than one (1) regular sexual partners (aHR = 3.949; 95%CI: 2.221, 7.022), lived in households of 3–5 members (aHR = 3.755; 95%CI: 1.706, 8.261), completed secondary school education (aHR = 2.154; 95%CI: 1.130, 4.108), and were circumcised (aHR = 2.218, 95%CI: 1.232, 3.993). Employed MSM had a 66% decreased likelihood to be retained on PrEP (aHR = 0.345; 95%CI: 0.168, 0.707). Similarly, MSM that used condoms consistently had an 85% decreased likelihood to be retained on PrEP (aHR = 0.149; 95%CI: 0.035, 0.632). Principal component regression analysis showed that the component with MSM with higher numbers of regular sexual partners had increased odds of adhering to PrEP (Crude Odds Ratio (cOR) = 1.32; 95%CI: 1.144, 1.530). The study highlighted that MSM using PrEP as the main method of HIV prevention were more likely to be retained and adherent to PrEP. There is need to emphasize PrEP use alongside other HIV prevention methods and targeted STI testing and treatment among PrEP users.
Assessing clinical and morphological features of megalotrichosis induced by Tyrosine kinase inhibitors versus Prostaglandins analogues
Authors: Gershon Rotem , Vishnevskia-Dai Vicktoria
Published: December 2024

Purpose

Describing the features of Megalotrichosis (MT) induced by Tyrosine kinase inhibitors (TKI) and differentiate it from Prostaglandins (PGs)–induced MT.

Methods

Medical data of patients with MT referred to our center between 2012–2021 were retrieved for: demographic parameters, medical, surgical and oncologic background, and ophthalmologic background along with diagnoses and treatment. Time from PGs/TKI introduction to MT presentation, MT clinical characteristics, associated complaints, and prescribed therapies in relevant cases were also documented. Ophthalmologic exam, ocular photography and data retrieved from medical records were used to assess MT features among the two groups. Morphological evaluation included number of upper (UL) and lower lid (LL) eyelash rows, poliosis, individual elongated eyelash and eyelash curvature. Masked evaluation of all the patients was performed.

Results

We found 11 patients, of which 6 treated with PGs for glaucoma and 5 treated with TKIs for non-ocular cancer suspected of dissemination. TKIs-induced MT was characterized by more individual elongated eyelashes (p = .047), UL eyelash rows (p = .03) and eyelash curvature (p = .076); poliosis characterized PGs-induced MT (p = .076). MT-associated complaints were more frequent in TKIs-induced MT (p = .06). time from drug administration to MT onset was shorter with TKI compared to PGs (median 176 Vs. 440 days, p = .257).

Conclusions

The study suggests that TKI-induced MT presents faster than PGs-induced MT and might be more bothering to patients. Knowledge of the morphological and clinical features that characterize each form of MT might be beneficial for patients and guide clinicians for intervention when needed. Larger cohorts are needed to reproduce and clarify our findings.
Am I in the centre of the story? Binaural sound used in audio and radio journalism: A systematic literature review
Authors: Paiva Ana Sofia
Published: December 2024

The aim of this systematic literature review (SLR) is to understand what research has been conducted on the use of binaural sound (i.e. a type of 3D sound) in audio and radio journalism in the last decade (January 2013 to December 2023). For this purpose, the PRISMA method was used and data were collected from WoS and Scopus. A corpus of six journal articles was obtained and the results demonstrate a need for greater literacy among journalists about binaural technology and its uses. In the cases in which it is applied, the most common editorial sections are those on society, culture, education and travel/tourism and the goal is to put the listener in the centre of the story and make them more immersed in the narrative. However, this SLR also shows that there is little research in this field and it is essential to create a specific grammar when binaural sound is applied to radio and audio journalism.
The podcasting circuit of culture in Brazil
Authors: Kischinhevsky Marcelo , Fraga Katia
Published: December 2024

This article borrows the ‘circuit of culture’ concept to investigate podcasting in Brazil, one of the most dynamic audio markets in the world. Focusing on production sphere, semi-structured interviews were conducted with managers of independent podcasts producers – Rádio Novelo and Central 3 – and Brazilian major broadcasting network, Sistema Globo de Rádio, with a portfolio of around one hundred and eighty podcasts. Data gathered indicate we are entering a new platformization era, which can be described by growing consolidation and sustainability issues, both to independent companies and legacy media.
Bootlegging the Airwaves: Alternatives Histories of Radio and Television Distribution, Eleanor Patterson (2024)
Authors: Gallego J. Ignacio
Published: December 2024

Review of: Bootlegging the Airwaves: Alternatives Histories of Radio and Television Distribution, Eleanor Patterson (2024)

Urbana, IL: University of Illinois Press, 192 pp.,

ISBN 978-0-25208-769-1, p/bk, $28.00
Risk of Cancer and Reoperation After Ileorectal Anastomosis and Ileal Pouch-Anal Anastomosis in Familial Adenomatous Polyposis
Authors: Bouchiba Hicham , Aelvoet Arthur S. , Pellisé Maria , Bastiaansen Barbara A.J. , van Leerdam Monique E. , Langers Alexandra M.J. , Balaguer Francesc , Miedema Thymen N. , Anele Chukwuemeka C. , Daca-Alvarez Maria , Bossuyt Patrick M.M. , Ricciardiello Luigi , Jover Rodrigo , Hompes Roel , Karstensen John G. , Latchford Andrew , Dekker Evelien ,   the European FAP Consortium
Published: December 2024

INTRODUCTION:

To prevent colorectal cancer, most patients with familial adenomatous polyposis (FAP) undergo (procto)colectomy with ileorectal anastomosis (IRA) or ileal pouch-anal anastomosis (IPAA). After surgery, these patients remain at risk of developing cancer in the remnant rectum or rectal cuff/pouch. We aimed to compare the long-term risk of cancer after IRA or IPAA in FAP.

METHODS:

We performed an international multicenter historical cohort study of FAP patients undergoing IRA or IPAA from 1990 to 2023. The proportion of patients developing cancer after surgery was estimated using the Kaplan-Meier method.

RESULTS:

(Procto)colectomy was performed in 685 patients (53.6% female); 366 (53.4%) had IRA, and 319 (46.6%) had IPAA. Median age at IRA and IPAA was 23 and 27 years, and the median follow-up was 12 and 15 years, respectively. Overall, 8 patients (2.2%) developed rectal and/or rectal cuff/pouch cancer after IRA and 0.9% after IPAA. The estimated 10- and 20-year cancer incidence after IRA vs IPAA was 1.6% vs 0.4% and 2.5% vs 0.9%, respectively (log-rank P = 0.15). Reoperations, mainly for extensive polyposis, were performed in 39 (10.7%) patients with an IRA and 24 (7.5%) patients after IPAA. The number of postoperative endoscopic surveillance endoscopies was higher in patients with an IRA compared with those with an IPAA (P < 0.001).

DISCUSSION:

Over the past 3 decades, few patients were diagnosed with cancer in the rectum or rectal cuff/pouch after (procto)colectomy in FAP. This might be due to an improved selection of the type of (procto)colectomy and close endoscopic surveillance including prophylactic polypectomies.
Multitarget Stool DNA Testing for Colorectal Cancer Screening in Clinical Practice
Authors: Jiang Linda , Yang Keming , Saul Melissa , Vajravelu Ravy K. , Schoen Robert E.
Published: December 2024

INTRODUCTION:

Few studies have evaluated multitarget stool DNA (mt-sDNA) in clinical practice. We analyzed mt-sDNA utilization at the University of Pittsburgh Medical Center.

METHODS:

We assessed mt-sDNA orders between January 1, 2017, and December 31, 2021. Data collection included electronic capture of mt-sDNA orders, completed stool submissions, and test results. Multivariable models were used to assess associations between mt-sDNA completion and results and age, sex, and race.

RESULTS:

There were 91,664 mt-sDNA orders in 73,704 patients. A total of 54.7% (40,337/73,704) completed an mt-sDNA test, and 7,424 (18.6%) tested positive. Completion rates increased by age <50–59 years (N = 12,818; 48.2%), 60–69 years (14,982; 56.3%), and ≥70 years (N = 9,850; 55.6%) (P < 0.0001). The completion rate for males (52.7%; 15,297/29,025) did not differ significantly from females (53.3%; 22,353/41,901) (P = 0.09). By race, the completion rates of White patients (54.1%; 34,874/64,512) and Asian patients (56.9%; 493/867) were higher than those of Black patients (38.8%; 1,699/4,376) (P < 0.0001). Test completion declined with repeat mt-sDNA orders, with ≤32% completion rate after ≥3 orders. In a multivariable model, older age was associated with greater likelihood of a positive test (odds ratio 1.22, 95% confidence interval 1.20–1.24, P < 0.0001), and Black patients had lower odds of a positive test (odds ratio 0.65, 95% confidence interval 0.56–0.76, P < 0.0001).

DISCUSSION:

Only 54.7% of patients completed their mt-sDNA test order. Older individuals were more likely to complete testing and test positive. Black patients were less likely to complete testing and, unexpectedly, less likely to test positive. Further exploration of mt-sDNA utilization including better understanding of the determinants of uptake, appropriateness, and evaluation of outcomes at colonoscopy is needed.
Longitudinal Associations Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Subclinical Cardiovascular Measures in Chinese Children
Authors: Qiao Yanan , Yang Lili , Yang Hui , Zheng Miaobing , Zhao Min , Xi Bo
Published: December 2024

INTRODUCTION:

The clinical utility of metabolic dysfunction-associated steatotic liver disease (MASLD) in predicting subsequent subclinical cardiovascular damages in pediatric population remains poorly understood.

METHODS:

Data on 1,161 Chinese children aged 10–15 years were used to assess the longitudinal associations of MASLD with subsequent subclinical cardiovascular measures.

RESULTS:

Compared with relatively healthy children, children with MASLD had abnormal vascular and cardiac structures, along with reduced cardiac diastolic function at the 2-year follow-up. In addition, children with MASLD had a significantly increased risk of high carotid intima-media thickness and left ventricular hypertrophy.

DISCUSSION:

These findings support the clinical utility of MASLD in predicting the development of subclinical cardiovascular damages in childhood.
Complot, especulación o muestra de coraje. Vandor y el retorno fallido de Perón en 1964
Authors: Dawyd Darío
Published: December 2024

En el presente artículo revisamos la acción del dirigente metalúrgico Augusto Vandor en el retorno fallido de Juan Perón a la Argentina en diciembre de 1964. Para hacerlo, presentamos la bibliografía que lo ubicó como responsable del fracaso, y aquella que trató de revisar esa acusación; recuperamos diversos testimonios, publicaciones periódicas y material de archivo para tratar de ubicar a Vandor en el contexto del retorno. A partir del cruce de esos materiales aspiramos a repensar algunos aspectos de la interna de ese movimiento político, así como aportar a la comprensión de las tensiones de los liderazgos dentro del mismo, durante unos años particulares del período de la proscripción.
«El dinero que nunca alcanza». Significados y evaluaciones de las transferencias monetarias en pandemia
Authors: Hornes Martín , Moyano Fernando
Published: December 2024

Este trabajo tiene el objetivo de analizar y reconstruir las evaluaciones de diferentes perfiles sociales sobre el dinero que el Estado Nacional y los Estados provinciales implementaron como política de asistencia durante la crisis sanitaria desatada por el virus COVID-19. A través de un trabajo de campo cualitativo realizado en la ciudad de Santa Fe (y alrededores)-Argentina, donde reconstruimos los presupuestos domésticos de casos seleccionados, analizaremos las estrategias y los repertorios de prácticas económicas movilizadas en los hogares, prestando atención a la presencia del dinero transferido por el Estado como una tecnología monetaria específica que penetra, se vincula y se ensambla con recursos financieros diversos. Esta aproximación nos permitirá problematizar las interpretaciones que producen los hogares asistidos para evaluar el dinero estatal, sus alcances y límites.