bluuebunny/crossref_metadata_2025 huggingface dataset:
INTEGRASI MODEL PROJECT BASED LEARNING DAN PROFIL PELAJAR PANCASILA DALAM PENERAPAN KURIKULUM MERDEKA
Authors: Sari Monika
Published: January 2025

Kurikulum Merdeka menjadikan pembelajaran selayaknya disesuaikan dengan karakteristik dari peserta didik. Hal ini agar potensi yang ada dalam peserta didik mampu dikembangkan selama ataupun setelah proses pembelajaran. Salah satu potensi yang harus dikembangkan adalah kemampuan kreativitas siswa. Kreativitas siswa perlu dikembangkan dengan model pembelajaran yang sesuai. Tujuan dari penelitian ini adalah untuk mengetahui integrasi model project based learning dan profil pelajar pancasila dalam penerapan kurikulum merdeka. Penelitian ini menggunakan metode studi literatur ( literatur review). Teknik pengumpulan data melalui sumber-sumber yang berkaitan dengan penelitian. Teknik analisis data melalui analisis mendalam terhadap sumber-sumber yang ditemukan. Hasil penelitian menunjukkan bahwa kemampuan kreativitas dalam peserta didik sangat penting dikembangkan karena kreativitas merupakan satu elemen dalam Profil Pelajar Pancasila di Kurikulum Merdeka. Penerapan model Project Based Learning mampu mengembangkan kreativitas siswa. Model Project Based Learning melibatkan peserta didik untuk merancang, mendesain dan menghasilkan sebuah proyek sehingga peserta didik dituntut untuk mrngrmbangkan ide-ide nya. Dengan model Project Based Learning ini kemampuan kreativitas peserta didik dapat di kembangkan.
PENGARUH COMPUTER ANXIETY DAN COMPUTER SELF EFFICACY TERHADAP MINAT MAHASISWA AKUNTANSI UNIVERSITAS NAHDLATUL ULAMA SIDOARJO MENGGUNAKAN SOFTWARE AKUNTANSI
Authors: Wicaksono Achmad , Rohmah Firda Yusnafa , Rahayu Dewi Sri
Published: January 2025

Perkembangan teknologi informasi telah mengubah paradigma bisnis dan profesi, termasuk dalam bidang akuntansi. Akuntan perlu memanfaatkan perangkat lunak akuntansi secara efektif untuk mengikuti perkembangan teknologi tersebut. Penelitian ini bertujuan untuk menganalisis dan memberikan bukti empiris tentang computer anxiety dan computer self efficacy terhadap minat mahasiswa dalam menggunakan software akuntansi. Penelitian ini menggunakan pendekatan kuantitatif dengan sampel populasi mahasiswa akuntansi Universitas Nahdlatul Ulama Sidoarjo yang mengikuti mata kuliah Aplikasi Komputer Akuntansi pada angkatan 2020-2021. Sampel diambil menggunakan metode probabilitas sampling dengan simple random sampling. Data primer dikumpulkan melalui penyebaran kuisioner kepada 40 responden, sedangkan data sekunder diperoleh dari berbagai sumber, termasuk jurnal, buku, dan data lainnya. Teknik pengumpulan data mencakup penggunaan kuisioner, uji validitas, uji reliabilitas, uji asumsi klasik, analisis regresi linear berganda, uji hipotesis, dan uji koefisien determinasi. Analisis data dilakukan menggunakan perangkat lunak SPSS versi 22. Hasil penelitian menunjukkan bahwa minat mahasiswa akuntansi dalam menggunakan software akuntansi dipengaruhi oleh tingkat computer anxiety dan computer self efficacy. Uji t (parsial) menunjukkan bahwa computer anxiety memiliki pengaruh positif dan signifikan terhadap minat mahasiswa akuntansi, sementara computer self efficacy tidak berpengaruh secara signifikan secara individu. Namun, secara keseluruhan, keduanya memiliki dampak positif dan signifikan terhadap minat mahasiswa.
ANALISIS KETERBACAAN LAPORAN TAHUNAN DAN RELEVANSI NILAI INFORMASI KEUANGAN TERHADAP AUDIT FEE
Authors: Ompusunggu Hermaya , Poniman Poniman , Husda Anggun Permata , Rustam Triana Ananda
Published: January 2025

Penelitian ini bertujuan untuk menganalisis keterbacaan laporan tahunan dan relevansi nilai informasi keuangan terhadap audit fee. Populasi dalam penelitian ini adalah Perusahaan manufaktur yang terdaftar di BEI periode 2018-2022. Teknik pengumpulan data dalam penelitian ini dengan teknik dokumentasi dengan mendokumentasikan laporan tahunan perusahaam manufkatur consumer googs and baverage dari tahun 2018-2022. Metode Analisis data dengan menggunakan software SPSS versi 25 dengan melakukan analisis deskriptif, uji asumsi klasik dan yang terakhir adalah uji t dan uji f untuk melihat hasil dari penelitian ini. Hasil dari penelitian ini adalah Keterbacaan laporan tahunan tidak berpengaruh signifikan terhadap audit fee, Relevansi nilai informasi keuangan juga tidak berpengaruh dignifikan terhadap audit fee dan secara simultan Keterbacaan laporan keuangan dan Relevansi nilai informasi keuangan juga tidak berpengaruh signifikan terhadap audit fee di perusahaan manufaktur sub sektor makanan dan minuman.
Analisis Penggunaan iHLD Pada Divisi Drafter dan Divisi SDI Di PT Telkom Akses Witel Tasikmalaya Menggunakan Metode SUS dan PIECES
Authors: Nazya Alifia Fatimatun , Guntara Rangga Gelar , Purwaamijaya Btari Mariska
Published: January 2025

Sistem iHLD diterapkan di PT Telkom Akses Witel Tasikmalaya untuk mendukung operasional Divisi SDI dan Drafter. Penelitian ini bertujuan untuk mengevaluasi kinerja dan kegunaan sistem iHLD menggunakan metode PIECES dan System Usability Scale (SUS). PIECES digunakan untuk menganalisis enam aspek utama: Performance, Information, Economics, Control, Efficiency, dan Service, sementara SUS mengevaluasi kegunaan sistem berdasarkan pengalaman pengguna melalui 10 pernyataan berbasis skala Likert. Hasil analisis PIECES menunjukkan bahwa sistem iHLD memiliki rata-rata kepuasan pengguna sebesar 3,86, yang berada dalam kategori PUAS, dengan kinerja yang efisien, informasi yang relevan, dan dukungan teknis yang cukup memadai. Namun, analisis SUS menempatkan sistem ini dalam kategori Marginal pada Rentang Acceptability Ranges dan kategori D pada Grade Scale, menunjukkan bahwa sistem masih menghadapi hambatan pada aspek antarmuka, navigasi, dan aksesibilitas fitur. Implikasi penelitian ini menyoroti perlunya peningkatan antarmuka pengguna, penyederhanaan navigasi, dan peningkatan fitur untuk memastikan kenyamanan serta kegunaan yang lebih optimal. Selain itu, peningkatan pelatihan pengguna dan dukungan teknis yang lebih responsif juga diperlukan untuk meningkatkan pengalaman pengguna. Penelitian ini menyimpulkan bahwa meskipun iHLD memberikan kontribusi positif terhadap kelancaran operasional, evaluasi dan pengembangan berkelanjutan sangat penting untuk memastikan sistem tetap relevan dan adaptif terhadap kebutuhan organisasi dan teknologi di masa depan. Penelitian selanjutnya dapat memperluas cakupan analisis dengan mempertimbangkan masukan dari pengguna akhir untuk pengembangan sistem yang lebih komprehensif.
Penerapan Metode Design Thinking Dalam Perancangan UI/UX Aplikasi Tafsir Mimpi Menggunakan Figma
Authors: Kurniasari Endah , Reyhandera Ristiafif Naufal , Oktaviani Oktaviani , Kembaren Suci Br
Published: January 2025

Penelitian ini bertujuan untuk merancang User Interface (UI) dan User Experience (UX) Aplikasi Tafsir Mimpi berbasis android dengan menggunakan Figma. Penelitian ini melibatkan calon pengguna aplikasi, yaitu masyarakat yang ingin mengetahui tafsir mimpi yang dialaminya terutama mimpi yang sampai mengganggu kualitas tidur, membuat perasaan menjadi cemas atau takut, hingga berdampak pada kehidupan sehari-hari. Perancangan UI/UX dibuat berdasarkan lima tahapan Design Thinking, yaitu Empathy, Define, Ideate, Prototype dan Testing. Hasil dari penelitian ini adalah prototipe UI/UX aplikasi Tafsir Mimpi “About Your Dream” berbasis android yang dibuat menggunakan software Figma. Uji coba dilakukan pada calon pengguna untuk mengetahui respons dan pemahaman calon pengguna terhadap desain yang dibuat. Pengujian dilakukan menggunakan System Usability Scale (SUS) untuk mengevaluasi kemudahan penggunaan aplikasi. Hasil pengujian prototipe aplikasi dengan SUS mendapat skor SUS sebesar 82,33, yang masuk dalam kategori “Good” dengan nilai B pada grade scale sehingga dapat disimpulkan prototipe aplikasi Tafsir Mimpi ini dapat diterima dengan baik dan sudah memenuhi kebutuhan pengguna.
Analisis Dan Visualisasi Data Menggunakan Looker Studio Pada Dataset New York City Property Sales
Authors: Purnama Indra , Setiani Yeni , Wibisono Farhan Ari Nur
Published: January 2025

Penulisan ilmiah ini berfokus pada analisis dan visualisasi dari dataset NYC Property Sales yang bersumber dari situs Kaggle. Penulisan ini berlatar belakang pada kemampuan untuk mengubah data kompleks dalam dataset menjadi informasi yang dapat digunakan untuk menyelesaikan masalah dan membuat keputusan yang tepat di masa depan. Analisis dan visualisasi ini digunakan dalam mengetahui permasalahan yang ada dalam dataset yaitu penurunan penjualan properti dan bertujuan untuk melakukan analisis dan visualisasi dengan hasil akhir berupa dashboard yang dibuat menggunakan Looker Studio. Metode analisis dan Exploratory Data Analysis (EDA) digunakan dalam penulisan ini dengan tahapan Data Collection, Data Preparation, EDA, dan Visualization. Dalam melakukan analisis dan visualisasi menghasilkan sebuah dashboard yang di dalamnya terdapat filter, scorecard, chart dan tabel. Dashboard yang telah dibuat dapat di akses melalui tautan berikut ini: https://lookerstudio.google.com/reporting/a60afdae-b109-4043-99dc-1fa3f4b3df9f/page/bQ64D. Dari pembahasan yang telah dilakukan,  dashboard yang telah berhasil dibuat dapat memberikan informasi terkait tren waktu pada penjualan properti, rata-rata harga properti, penyebaran distribusi penjualan dan transaksi penjualan dalam suatu borough, kelas bangunan ataupun tahun pembuatan bangunan properti. Hal ini dapat memberikan informasi bagi para investor untuk melakukan investasi di waktu yang tepat serta memberikan wawasan yang berharga.
Rancang Bangun Purwarupa Aplikasi Presensi SMK 1 Manggar Berbasis QR Code Web
Authors: Yudi Herza Maulana , Syafrudin Syarifah Azharina
Published: January 2025

Pencatatan presensi bagi siswa di dalam lembaga pendidikan adalah salah satu hal yang wajib dilakukan sebagai dasar nilai bagi tolok ukur siswa, di mana kehadiran siswa merupakan salah satu nilai penunjang tambahan yang dapat digunakan untuk mendukung poin nilai siswa di setiap tahun ajaran atau semester. Penelitian ini memiliki tujuan membangun sebuah aplikasi untuk pencatatan kehadiran siswa SMK 1 Manggar dengan berbasis QR Code pada web agar rekapitulasi angka kehadiran siswa menjadi lebih efektif dan efisien. Metode penelitian ini terdiri dari; perencanaan, studi literatur yang relevan, merancang struktur basis data dan melakukan pengujian menggunakan dukungan perangkat lunak sistem operasi windows, PHP dan MySQL. Hasil pengujian yang sudah dilakukan didapatkan hasil yang diharapkan, tampilan webiste tidak ada kesalahan dan semua halaman dapat berjalan sesuai yang diharapkan.
Evaluation of Sucker Category for In Vitro Bud Proliferation and Genetic Association of Mother and Surrounding Suckers of Musa spp
Authors: Victor Amankwaah , Rebecca Biney , Ruth Prempeh , Emmanuel Digooh , Francis Amoako , Lily Batsa , Obeng Agyei , Marian Quain
Published: January 2025

Commercial production of plantain (Musa spp) is challenging due to insufficient planting materials as vegetative propagation using the same planting materials year after year causes cultivar decline due to pathogen load. Although different types of plantain suckers (maiden, sword and peeper) are available as sources of ex-plant for in vitro propagation, there is a dearth of information on the appropriate type of sucker to be used as source of ex-plants for in vitro initiation and bud proliferation. The purpose of this study was to evaluate the effect of different sucker types of two local plantain cultivars for in vitro establishment, their proliferation performance (bud and shoot number) on Recipient á Immersion Temproraire Automatique (RITA) temporary immersion bioreactor system (TIBS). This research also assessed the relatedness of sucker types at different developmental stages. Explants obtained from three different sucker types (maiden, sword and peeper) of the two local plantain cultivars Apantu (false horn plantain) and Apem (french plantain) were aseptically initiated on a supplemented Murashige and Skoog’s (MS) complete medium while the ex-plant multiplication was done on RITA@ TIBS. Genomic DNA from cigar leaves of the parent plant and suckers derived from the parent plant (maiden, sword and peeper) were also extracted using a modified Cetyl trimethylammonium bromide (CTAB) protocol and analyzed with 15 SSR markers. Analyzed data shows a significant difference (p ≤ 0.01, p ≤ 0.05) in ex-plants contamination, the number of leaves and shoots. Sword sucker had the lowest contamination of 0% among the three explants used for initiation. Suckers arising from a parent were more closely related to suckers of the same age than to their parent plant. These advances are expected to boost the proliferation rates of tissue culture plantain for commercial production.
The Impact of Obesity on Acute Skin Toxicity from Radiation Treatment for Breast Cancer: Opportunities to Predict and Address
Authors: Lombardo Joseph F , Poiset Spencer J , Burke Sara E , Shah Malak , Doyle Laura A , Harrison Amy S , Choi Kamila Nowak , Rese Annaisabelle , Hegarty Sarah E , Anne Pramila R , Simone Nicole L
Published: January 2025

Rationale: As radiation therapy techniques have improved, skin toxicity from breast radiation is less common. However, as the rates of metabolic syndrome and obesity increase, we sought to determine the impact of obesity on acute skin toxicity following radiation therapy for early-stage breast cancer and explored potential strategies for mitigating toxicity.
Objectives: A retrospective analysis was conducted on 355 early-stage breast cancer patients who underwent radiation therapy. Patient demographics, clinical characteristics, radiation details, and skin toxicity were recorded. Logistic regression models were used to assess the association between obesity (BMI ≥ 30) and skin toxicity, considering treatment variables such as radiation dose, boost, and wedge use.
Findings: Higher BMI was significantly associated with increased odds of grade 2 or higher skin toxicity (OR = 4.24, p < 0.001). The use of wedges showed a potential protective effect against toxicity in overweight patients (OR = 0.48, p = 0.060). Multivariable analysis revealed that younger age, higher BMI, and an increased number of radiation segments were associated with a higher likelihood of toxicity. Recurrence rates did not differ significantly between BMI groups.
Conclusion: Obesity is a significant risk factor for acute skin toxicity in breast cancer patients undergoing radiation therapy. Strategies to mitigate toxicity, such as personalized treatment planning incorporating wedges and optimizing radiation dose, are crucial for improving patient outcomes. Future research is warranted to explore the role of dietary interventions or personalized therapies to minimize acute radiation toxicity for patients living with metabolic dysfunction or obesity.
Fetal Nasal Flow Doppler and Breathing Patterns for Prediction of Preterm Labor: A Prospective Cohort Study
Authors: Hassan Ahmed , Abdou Hossam , Elhossary Hend , Abdel Salam Eman , Saeed Marwa , AbdElsalam Karim
Published: January 2025

Background: Expectation of preterm birth is very hard for obstetricians although there are various ways such as fetal fibronectin, different cytokines, cervical length measurement and elastography was implemented for this reason. Doppler might be used to evaluate fetal nasal fluid flow but this test was not made in expecting preterm labour til now.

Aim: To study the value of fetal breathing movement patterns and nasal flow Doppler in women with symptomatic preterm labor.

Patients and Methods: This prospective study was conducted at tertiary care hospital at Helwan University Hospital from April 2022 till October 2022 and performed on a total of 81 pregnant women at 28 to 37 weeks gestation with symptomatic preterm labor.

Results: During this study, 100 patients were assessed for eligibility and 81 patients were included in the study. Of all eligible patients, 12 patients were excluded from the study based on the inclusion criteria and 7 patients refused to participate in of the study. Ultimately, the analysis was based on the data of 81 pregnant women at 24 to 37 weeks gestation with symptomatic preterm labor. The current study revealed that the age, Body mass index, Gestational age, Cervical dilation and Cervical length was 27.4 ± 4.8 years, 29.4 ± 2.5 kg/m2 , 31.2 ± 2.3 weeks, 3.3 ± 0.6 cm and 15.6 ± 2.2 mm respectively and 25.9% of cases were nulli parous. Our study results revealed that breath movement was not detected in (14.8%) of cases, was irregular in (17.3%), while it was regular in more than two thirds (67.9%) of cases and 44.4% of the studied cases had delivery within day 1 (24 hours).

Conclusion: Adding Doppler study to the upper respiratory tract tests could help in assessment of fetal nasal fluid flow. Inspiration/ expiration number ratio ≤1.12 had highest sensitivity and PPV in predicting delivery in day-1. As a result, only inspiration/expiration number ratio was related to higher possibility for preterm delivery.
Factors Associated with Uptake of Tetanus Toxoid Vaccine among Pregnant Women Attending Antenatal Clinic at Nyamagana Health Centre Mwanza-Tanzania
Authors: Marandu Gotfrida , Paulo Bernadeta
Published: January 2025

Background: Maternal and neonatal tetanus remains a public health problem in low- and middle-income countries despite increasing investment in tetanus toxoid vaccines TTV). Tanzania still records fatalities from tetanus, predominantly in women of reproductive age and newborns. We aim to determine the factors associated with low uptake of tetanus toxoid vaccine among pregnant women attending the antenatal clinic at Nyamagana Health Centre in Mwanza, Tanzania

Method: A prospective cross-sectional health facility-based study was conducted. A total of 383 pregnant women attending the antenatal clinic at Nyamagana Health Center in Mwanza, Tanzania, were recruited using simple random sampling. Structured questionnaires were used to collect data. Data were recorded in Microsoft Excel, cleaned, and analyzed using STATA version 14.

Results: The predominant age of the respondents was 21–26 years 34.7%). A total of 245 64%) participants were married. A total of 172 44.9%) participants had secondary education. Overall, 226 59.01%) of participants were unaware of the number of doses of tetanus toxoid TT) vaccine required during pregnancy, and 205 53.50%) were unaware of tetanus immunization. Notably, 178 46.48%) of respondents did not know the importance of receiving the tetanus toxoid TT) vaccine. There was a significant relationship between socio-demographic characteristics and awareness of the importance of the TT vaccine.

Conclusion: Pregnant women in Nyamagana Health Center, Mwanza, Tanzania, are not receiving the recommended TT vaccinations and lack awareness of their importance. Efforts are needed to educate expecting mothers and increase vaccination rates.
Epistaxis Guidelines: A Comprehensive Guide to Manage Epistaxis in the Primary Care Setting
Authors: Avish Persaud , Dhanushya Battepati , Erin Koffman , Andrew Prince , Mark Prince
Published: January 2025

Nosebleeds, or epistaxis, is a common problem that affects almost 60% of Americans during their lifetime. Epistaxis can significantly impact a patient's health and quality of life; it is critical that primary care physicians be familiar with the most up-to-date guidelines on managing epistaxis. Primary care providers are pivotal in being able to stabilize and treat epistaxis, to avoid the need for unnecessary interventions and to reduce the risk of patient harm. The American Academy of Otolaryngology recently updated otolaryngologic clinical practice guidelines (CPG) on epistaxis management. As the circulation of these guidelines has been limited to a subspecialty journal, we provide this focused review to clarify and disseminate the epistaxis guidelines for the frontline primary care physician.
HEADACHE
Authors: Marieta Dumitrache , Anitescu Magdalena , Cioboat Miruna
Published: January 2025

Headache or cephalalgia can be primary - migraine, with/without aura, tension-type, cluster-type, or other primary (idiopathic) headaches, and secondary headaches of multiple etiologies. Emergency signs in headaches are: violent headache (hemorrhage meninges), convulsions in epilepsy, fever, neck pain (meningitis), neurological disorders (vertigo, paresis, diplopia). Migraine begins with aura (20%), with reversible phenomena within 60 min, with small scotoma that expands, associated with homonymous, lateral hemianopsia (or blindness), scotoma bordered by zigzag bright spots (sensory aura may present progressively transient hemiplegia, auditory hallucinations). All signs regress without sequelae. Treatment in primary headache requires elimination of risk factors: stress, fatigue, food chocolate, coffee, wine, cheese, aspartane, prophylactic treatment as needed with propanolol methysergyl, calcium channel blockers, amitriptyline. Treatment of the acute migraine episode with acetaminophen; in aura, ergotamine tartrate, sumatriptan, topiramate, metoclopramide are indicated. Secondary headache recognizes multiple causes: ocular, cerebral, postneoplazic, posttraumatic, postinfectios, in which the treatment is that of the causal condition.
Decrease of Vision in Senescent
Authors: Dumitrache Marieta , Cioboat Miruna
Published: January 2025

Vision loss in the elderly is caused by: physiological aging of the eye, eye disease specific in the elderly (cataract, DMLV, NO impairments), non-age specific eye disease similar to adult disease and multiple general pathology determination given by aging. Vision in the elderly declines over time, through an inevitable evolutionary process, aggravated by the involution of senescence. Ocular change with age affected: cornea, the trabecular meshwork lens, retina, choroid, vitreous, sclera and NO. Vision loss in elderly patients is often chronic, binocular, asymmetric. Presbyopia represents the physiological disorder of the eye, with on onset around the age of 45 which is manifested by the progressive decrease of the accommodative amplitude in near vision (the accommodation deficit by emmetrope is +0,5D at 45 years old, and 70 years the accommodation power of the lens is 0, needs +3,5 +4D for near vision.

Acute vision loss unilateral in amaurosis fugax, vitreous hemorrhage, AMD, ACR, VCR obst DRR, bilateral in: trachoma, AMD, diabetic hypertensive, retinopathy, infiltrative optic, neuropathy, cortical infarction, hemorrhage. Chronic vision loss in elderly unilateral in: cataract, DMLV, RD, keratopathies, uveitis, DR, glaucoma, trauma macular disease, affects of NO, and bilateral in: GPUD decompensated, secondary glaucoma, maculopathy, papillary edema in HIC. Decreased vision in age related eye pathology in: cataract (senile, pathological, complicated), glaucoma (GPUD, GSUD), DMLV atrophic, exudative), pathological change of NO (NOIA), artetitic (Horton’s disease), nonarteritic. The general cause of AV decrease cause: systemic diseases: DM, HTN, ASC, stroke, mental illnesses (depression, dementia).

The management of vision loss must begin with the earliest possible diagnosis of the eye disease and the establishment of preventive and curative therapeutic opportunities – each age decade being evolutionary and nonregressive.
Військова педагогіка як складова кадрового менеджменту в Силах оборони України: онтологічний вимір
Authors: Gurkovskyi Volodymyr , Semenenko Lilia , Romanenko Yevhen , Dobrovolskyi Yuzef , Polishchuk Oleksandr , Tkach Ivan
Published: January 2025

Мета роботи: проведення онтологічного аналізу військової педагогіки та визначенні її ролі в кадровому менеджменті Сил оборони України в умовах сучасних військових загроз. У дослідженні розглядатиметься сутність військової педагогіки, її структурні компоненти, а також її значення для забезпечення ефективної підготовки військово-службовців.
Метод дослідження: Використано методи аналізу, порівняння, узагальнення та інтерпретації результатів досліджень у галузі військової педагогіки, з урахуванням українського та міжнародного досвіду.
Практична цінність дослідження: Дослідження спрямоване на вдосконалення системи підготовки військових кадрів, зокрема на розроблення рекомендацій щодо реформування військової освіти та кадрового менеджменту.
Цінність дослідження: висвітлюється актуальність впровадження інноваційних підходів у військовій педагогіці, що дозволить підвищити ефективність підготовки військових фахівців до виконання завдань в умовах нинішніх реалій. За результатами дослідження зроблено висновок про те, що розвиток військової педагогіки є важливим елементом інтеграції України з Північноатлантичним альянсом.
Майбутні дослідження: аналіз впливу інноваційних технологій на процес підготовки військових кадрів, розробку методик психологічної реабілітації та адаптації військово-службовців після участі в бойових діях.
Аналіз методологічного забезпечення обліку та оцінки військових витрат та втрат
Authors: Mogylevska Viktoriia , Sotnyk Viktoriia , Kotsiuruba Ruslan , Marchuk Zlatina
Published: January 2025

Мета роботи: проаналізувати існуючі підходи і методи обліку та оцінки збитків, завданих системі Міністерства оборони України внаслідок збройної агресії.
Метод дослідження: порівняльний аналіз, індукція та дедукція.
Результати дослідження: Проведено аналіз методологічної бази з питань обліку та оцінки військових витрат та втрат, спричинених воєнними діями, з урахування Міжнародних стандартів оцінки вартості. Надано рекомендації щодо розробки єдиних форм обліку збитків в системі Міноборони та розширені показників військових втрат, що дасть можливість визначити реальні збитки.
Теоретична цінність дослідження: Розглянуті в статті методи оцінки збитків дають можливість обрати відповідний підхід для визначення військових витрат та втрат, з урахуванням мети та цілей проведення такої оцінки.
Цінність дослідження: Проведений аналіз діючої методики визначання військових втрат показав наявність ряду недоліків, пов’язаних з відсутністю єдиних форм обліку збитків та потребою у врахуванні додаткових показників військових витрат.
Майбутні дослідження: Під час подальших досліджень доцільно розглянути питання щодо удосконалення механізмів фіксації, обліку та оцінки військових втрат, завданих внаслідок бойових дій.
Методичний підхід визначення напрямів та показників підвищення оборонної достатності держави як елементу методології оцінювання її оборонних спроможностей
Authors: Semenenko Oleh , Horbatiuk Volodymyr , Abramova Maryna , Tarasov Oleh , Mytchenko Serhii , Vovk Yaroslav
Published: January 2025

Мета роботи: висвітлити підхід до обґрунтування напрямів підвищення оборонної достатності держави (її типові показники), що є актуальним за сучасних умов забезпечення оборонних спроможностей держави.
Метод дослідження: аналізу; синтезу; порівняння; формалізації та оцінювання матеріалу.
Результати дослідження: виокремлено показники, які відображають можливі напрями підвищення оборонної достатності держави за такими критеріями як “захист”, “поточні спроможності” та “розвиток” згідно з наведеним підходом їх обґрунтування, які можуть бути використані під час визначення актуальних стратегічних напрямів забезпечення обороноздатності в середньо- та довгостроковій перспективі.
Теоретична цінність дослідження: використання наведеного у статті підходу до визначення напрямів підвищення оборонної достатності держави, а також врахування областей зважених фактичних значень\ значень потреби n-показників оборонної достатності може бути використано як елемент методології оцінювання оборонних спроможностей країни.
Persepsi Mahasiswa Terhadap Pentingnya Mata Kuliah Akuntansi Forensik Sebagai Pengajaran di Perguruan Tinggi (Studi Pada Universitas Nahdlatul Ulama Nusa Tenggara Barat)
Authors: Solatiyah Baiq , Yakub Muhammad
Published: January 2025

Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa jurusan Ekonomi Islam Fakultas Ekonomi Universitas Nahdlatul Ulama Nusa Tenggara Barat terkait minat dan pemahaman pada mata kuliah akuntansi forensik yang ada pada kurikulum pembelajaran jurusan ekonomi islam. Penelitian ini adalah penelitian kualitatif yang menggunakan metode wawancara sebagai pengumpulan bukti. Partisipan pada penelitian ini terdiri dari mahasiswa angkatan 2021 dan 2022 yang telah menempuh pembelajaran mata kuliah akuntansi forensik. Tahapan analisis data dalam penelitian ini meliputi pengumpulan data, reduksi data, penyajian data, serta penarikan kesimpulan. Hasil penelitian menunjukkan bahwa persepsi dari segi minat mahasiswa ekonomi islam terhadap mata kuliah akuntansi forensik memberikan tanggapan positif yaitu menganggap mata kuliah akuntansi forensik sangat menarik dan penting dijadikan sebagai pembelajaran pada jurusan ekonomi islam, sedangkan persepsi mahasiswa ekonomi islam dari segi pemahaman menunjukkan bahwa mata kuliah akuntansi forensik sangat mudah dipahami walaupun ada juga mahasiswa yang memiliki persepsi sangat sulit memahami mata kuliah akuntansi forensik.
The Multiple and Changing Faces of Psychotrauma and its Psychological Consequences
Authors:   , Jongedijk Rudolf Albert
Published: January 2025

The concepts of psychotrauma and post-traumatic stress disorder or PTSD have become increasingly popular in recent decades, not only in scientific literature and in therapy rooms, but also in the media and in everyday language. Yet the concept of PTSD only exists since 1980. This dissertation contributes to the knowledge about the manifestations of psychotraumatic events and their psychological consequences by investigating how PTSD emerged and whether the symptoms described in the PTSD concept correspond to those of traumatized patients.

From a historical perspective, a literature review examined how posttraumatic disorders developed and under what circumstances and influences this took place. A great diversity of described symptoms and syndromes was found over the past century and a half. It turned out that these often arose under time-bound social, political, legal and scientific circumstances and were accompanied by intense debates about their right to exist.

Research was then conducted using various statistical methodologies. In a study on the traumatic stressor criterion it was shown that, among other things, traumatic events, but also re-experiencing symptoms, did not occur specifically in PTSD alone, but also in various other mental disorders like unipolar mood disorders.

Subsequently, Latent Profile Analysis (LPA) was used in two studies within two large samples of traumatized patients with a veteran and refugee background, respectively. Three subgroups of patients were identified which were characterized by symptom severity. The subgroups showed a wide range of PTSD, depression, anxiety and somatization symptoms, which were closely interrelated. Specific trauma types, coping styles, personality traits, and gender were associated with certain symptom severity subgroups.

Finally, a study was conducted among a sample of both traumatized police officers and veterans to examine the associations between PTSD criteria and treatment outcome with Linear Mixed Model analyses (LMM). 51% Of participants reported clinically significant improvement for PTSD symptoms and 45% for symptoms of general psychopathology. Trauma characteristics and the severity of the four PTSD symptom clusters pre-treatment were not associated with changes in total PTSD scores from pre- to post-treatment. However, some trends were found like e.g., that higher severity of cluster C symptoms before treatment tended to be associated with smaller improvement in cluster E, and higher severity on cluster D with greater improvement of the same cluster D.

The dissertation ends with a proposal for a hybrid diagnostic model for patients with post-traumatic complaints with both categorical and dimensional diagnostic elements. This model consists of both subtypes that can be defined in addition to PTSD and the concept of staging. In this way, the heterogeneity of post-traumatic symptomatology can be described in a more personalized way and treatment can be applied in a more tailor-made manner.
Tracing Heterogeneity in T-cell Malignancies in Time and Space
Authors:   , Poort Vera Maria
Published: January 2025

Our bodies renew some organs frequently, such as the intestines and skin, while others, like the brain and heart, rarely renew. This renewal process involves cell division, during which mutations can occur. While many mutations are harmless or corrected by cells, some mutations can disrupt cell functions and lead to cancer. These mutations, unique to each cell, act as a "barcode," allowing researchers to trace cell lineage and study cancer development using family tree methods. Advances in DNA analysis have improved the precision of this approach, enabling a deeper understanding of cellular mutations and their consequences.

This thesis employs the family tree principle to study T-cell leukemia and lymphoma, two types of immune system cancers. Healthy T-cells develop through a stepwise maturation process, enabling them to recognize foreign substances and activate the immune system. In T-cell leukemia and lymphoma, DNA mutations disrupt this maturation, causing cells to remain immature. These faulty cells multiply, leading to leukemia when accumulated in the blood and bone marrow or lymphoma when found in the lymph nodes. In the Netherlands, 20 children are diagnosed annually with these cancers, and while 80% recover through intensive chemotherapy, the treatment is lengthy and burdensome. This research seeks to develop more effective, less toxic treatments.

Chapter 2 explores the varying characteristics of tumor cells within a single patient, corresponding to different stages of T-cell maturation. Using family tree analysis, the study revealed that leukemia cells can exhibit characteristics of both normal and reverse T-cell development. This finding challenges the previous understanding that leukemia cells uniformly display immature features. Moreover, ongoing T-cell maturation within leukemia cells was demonstrated for the first time, offering insights into cancer progression.

Chapter 3 compares healthy developing T-cells with leukemia cells, identifying differences in surface characteristics and internal processes. At relapse, leukemia cells exhibit stem cell-like properties, such as slower division and adaptability, making them more resistant to therapies targeting rapidly dividing cells. The study's dataset is publicly available to support further research and hypothesis testing.

Chapter 4 focuses on T-cell lymphoma, which primarily accumulates in the lymph nodes but often spreads to multiple organs, such as the bone marrow and brain. Family tree analysis revealed that lymphoma cells continuously migrate between organs from the onset of the disease, contrasting with other cancers that typically spread later.

The findings in this thesis enhance our understanding of T-cell leukemia and lymphoma, their progression, and their distinct characteristics. This knowledge provides a foundation for developing innovative therapies, such as immunotherapy, to target cells with specific features. These advancements aim to improve treatment efficacy while reducing the burden and side effects for patients.
Eigenrisicodragen bij ziekte en arbeidsongeschiktheid
Authors:   , Mouselli Hendarin
Published: January 2025

With regard to the Sickness Benefits Act (ZW) and the Return to Work (Partially Disabled Persons) Regulations (WGA), employers have a choice between taking out public insurance or bearing the excess themselves. This doctoral thesis provides insight into how rules governing self-insurance for ZW and WGA promote or hinder sick leave and reintegration by the current or former employee and how the rules affect the legal position of the current or former employer and the current or former employee. By being self-insured, employers become directly responsible for the reintegration and payment of ZW and WGA benefits to their employees and former employees. They are also given administrative powers. Under the ZW, self-insured employers are given the authority to prepare certain administrative decisions for the Employee Insurance Agency (UWV). Under the WGA, self-insured employers have more far-reaching authority and are authorised to make certain administrative decisions (in the first instance and in objection procedures) as autonomous administrative bodies. Given the authority vested in employers and former employers vis-à-vis employees and former employees, the ZW and the Work and Income (Capacity for Work) Act (WIA) contain various rules to prevent misuse of self-insurance. However, this doctoral thesis shows that self-insurance creates several bottlenecks that could be detrimental to the legal position of those involved and to the effectiveness of the system.
Shining light on dendrites
Authors:   , Herstel Lotte Julia
Published: January 2025

Brain cells receive signals of thousands other brain cells via synaptic connections. These positive and negative signals are processed in the dendrites and determine the activity of the receiving brain cell. In this thesis, Lotte Herstel studied the interaction of these synaptic signals and different ion channels in dendrites. She made recordings of the small electrical signals in individual brain cells and combined these with new biosensors and advanced microscopy to shine light om the molecular processes that take place inside brain cells and their dendrites.
Her work demonstrates that different brain cells employ specific mechanisms to adjust their dendrites when circumstances are changing. She also shows how positive and negative signals in dendrites are coordinated. In addition, Lotte studied the development of brain cells from mice and humans. She shows in mice that brain development is influenced by experience right after birth and she describes the specific stages that occur in developing human brain cells until the first successful action potential firing.
The results from this PhD thesis demonstrate how the interactions between different electrical and molecular signals determine and able to change the activity of brain cells. This fundamental knowledge is necessary to understand how information is processed in our brain.
Assessment of imaging markers for intracranial aneurysms using artificial intelligence
Authors:   , Vos Iris Nadine
Published: January 2025

Intracranial aneurysms are bulges in brain blood vessels that, while often harmless, can rupture and cause a life-threatening subarachnoid hemorrhage. Since unruptured intracranial aneurysms are generally asymptomatic and therefore are often not diagnosed until rupture, early detection and treatment are crucial. Aneurysms can be diagnosed using time-of-flight Magnetic Resonance Angiography, a widely used non-invasive imaging method. Although the pathogenesis of intracranial aneurysms remains largely unknown, research suggests a strong familial deposition. This has prompted recommendations to screen first-degree family members of patients with (ruptured) aneurysms, usually at five-year intervals since aneurysms can develop at any time. However, current screening methods have limited effectiveness. The identification of risk factors capable of identifying individuals at the highest risk for aneurysms can improve the screening process. High-risk individuals could be screened more frequently based on an initial evaluation of the brain scan, whereas the screening frequency for low-risk individuals could be reduced or even stopped. This thesis explores computer-assisted and artificial intelligence-based approaches for (semi-)automated assessment of imaging markers associated with intracranial aneurysms, focusing on the circle of Willis. Two methods are presented to semi-automatically assess artery diameters and artery bifurcation angles. The analysis of large cohorts revealed notable anatomical differences, including sex-specific differences in the anatomy of the circle of Willis and associations between specific artery diameters or bifurcation angles and aneurysm presence, offering new insights into potential risk factors. In addition, the thesis investigates the use of advanced artificial intelligence techniques, such as graph neural networks, to analyse circle of Willis topology. By exploring methods for model interpretability and calibration, this research advances towards fully automated, explainable, and clinically implementable AI systems.
Children’s Differential Susceptibility to Peer Rejection and Acceptance
Authors:   , Liu Danni
Published: January 2025

Children vary in how strongly they are affected by peer acceptance and rejection, with some children showing heightened sensitivity to these experiences. This heightened susceptibility can be seen as a "for better and for worse" effect, where children who are more negatively impacted by peer rejection also benefit more from peer acceptance. This dissertation investigates sensory processing sensitivity (SPS) as a potential marker of this susceptibility among Chinese children and adolescents. Study 1 validated a Chinese version of the Highly Sensitive Child (HSC) scale for measuring SPS. Results indicated that the Chinese HSC had good psychometric qualities, though refinements may be needed for use with younger children. Study 2 found that children with higher levels of SPS were more emotionally reactive to imagined peer acceptance and rejection scenarios, supporting the "for better and for worse" effect. Study 3 examined children's reactions to both peer acceptance and rejection feedback in a simulated social media environment among the same children. Results revealed variations in children’s reactivity to peer feedback but limited evidence for SPS as a consistent marker of susceptibility. Using a longitudinal design, Study 4 again found limited support for SPS as a marker of heightened susceptibility: Children higher in SPS generally did not show stronger associations between their peer relationships and their social-emotional functioning over time. Overall, the dissertation suggests that SPS functions at best as a context-dependent marker of susceptibility, rather than a universal one, and that long-term research may be needed to better understand how differential susceptibility may (or may not) develop over an individual’s lifespan. These findings may ultimately inform strategies to support children who are more sensitive to peer experiences.
A functional approach to articular cartilage repair with a critical note on animal experimentation
Authors:   , Fugazzola Maria Carlotta
Published: January 2025

Synovial joints are quite literally the hinges of the musculoskeletal system, and the articular cartilage plays a crucial role in absorption and dissipation of forces during movement. Focal cartilaginous and osteochondral lesions can be of traumatic or chondropathic degenerative origin. The fibrocartilaginous repair tissue that forms naturally at the site of cartilage damage has inferior biomechanical properties tothe original hyaline cartilage, and so eventually undergoes fibrillation and degeneration, leading to further disruption of joint homeostasis. Both types of lesion will therefore ultimately lead to activity-related pain, joint effusion and decreased mobility, frequently progressing to osteoarthritis. William Hunter’s statement made in 1743 of articular cartilage being a tissue that, “when destroyed, .. is never recovered” is sadly still applicable. This thesis approaches the issue of focal cartilaginous lesion repair from different angles.

The first chapter reviews experimental research on surgical cartilage restoration techniques performed so far in equine models. The high number of equine ongoing studies and the diversity of approaches used, is proof of a still missing long-term solution. Positive results in the reported studies mostly refer to the presence of collagen type 2 or glycosaminoglycans (GAGs) in the (immuno)histochemical analysis of the repair tissue and omit to analyse the crucial biomechanical characteristics of obtained repair cartilage. This aspect ultimately determines the resilience of the repair cartilage and reflects the long-term performance within the biomechanically challenged joint.

Furthermore, also the position within the joint of the damaged area needs to be taken into account, as it has been shown that composition and biomechanical proprieties vary in dependance of their specific location (in line with specific loading conditions). These location-dependent variations have not yet been investigated in the equine stifle. In the second chapter the biochemical composition and architecture of three differently loaded areas of the equine stifle is analyzed. It emerged that glycosaminoglycan content was different between all sites, as were several biomechanical characteristics (equilibrium modulus, dynamic modulus and viscosity). The two weightbearing areas and the non-weightbearing area differed in collagen, parallelism index and angle of collagen fibers. We had hypothesized that site differences also would correlate with the biomechanical characteristics of the cartilage. Indeed, strong correlations were found between several biochemical (proteoglycan content) and biomechanical characteristics (equilibrium modulus, dynamic modulus and phase shift) as well as between architecture (collagen orientation angle) and biomechanical characteristics (equilibrium modulus, dynamic modulus and phase shift).
Optimising performance and welfare in equine athletes
Authors:   , Siegers Esther Willemijn
Published: January 2025

Equestrian sports are popular and have benefits to human health, however concerns about equine welfare have surfaced. This thesis describes methods to improve both performance and welfare of horses.

Standardised exercise tests (SETs) are essential for evaluating the physical fitness of horses across different disciplines. During discipline-specific SETs, exercise capacity can be assessed and the effects of training can be evaluated.

SETs were used to evaluate young Friesian stallions during a 10-week training programme which is part of the assessment to become a studbook approved breeding stallion. In 2020, SET results revealed that the horses were overtrained during this training programme. Gait analysis showed more variation in stride characteristics and asymmetry when horses were fatigued. The participating horses had different stride characteristics and levels of asymmetry compared to ranges described for Warmblood horses and Iberian horses, demonstrating the necessity for breed-specific reference ranges for gait kinematics. Training frequency was reduced in the 2021 training programme, and high and low intensity training sessions were alternated. This resulted in improved fitness during the 10 weeks of training.

Prevention of overheating is important when horses perform in challenging climatic conditions. Training horses for 1 hour per day for 14 days in an heated indoor arena is an effective method to increase heat storage capacity. Another effective method to reduce thermal strain is by pre-cooling the horses before exercise.

Seemingly small, but easily achievable changes in training and cooling regimes can have a significant impact on the welfare and the of sport horses.