bluuebunny/crossref_metadata_2025 huggingface dataset:
­Evolution of the most species-rich family of simple thalloid liverworts (Aneuraceae): a time-calibrated perspective into its evolutionary history and diversification
Authors: Anantaprayoon Nopparat , Wonnapinij Passorn , Leavitt Steven D. , Kraichak Ekaphan
Published: February 2023

Aneuraceae is the largest family of the simple thalloid liverworts. Despite simple morphological features, this family is well-known for its unique ecology, cryptic diversity, and species-rich lineages. In this study, we explored the evolutionary history and diversification of the Aneuraceae. Investigating the effects of fossil calibrations on divergence time estimates and how recognizing cryptic species impacts macroevolutionary analyses. We used publicly available nucleotide sequences to reconstruct chronograms of Aneuraceae with representatives from subclass Metzgeriidae as outgroups. We also examined the consequences of different calibrations in chronogram reconstruction. Then, the resulting time-calibrated phylogeny was employed to reveal diversification dynamics with lineage through time plots (LTTPs), γ-statistics, and Bayesian Analysis of Macroevolutionary Mixtures (BAMM). The Aneuraceae had originated and created diversity since the Lower Carboniferous (352.75 Mya, 95%HPD: 505.79–264.59) to Upper Devonian. Lineage diversification of Aneuraceae species was consistent with late bursts of speciation with two significant rate shifts in genus Riccardia: one at the crown node of the genus and the other at the Neotropical clade. Including cryptic taxa resulted in an additional rate shift at the crown node of Aneura. Aneuraceae originated during the middle Palaeozoic Era, similar to other early terrestrial plants, although different fossil calibrations significantly affected the estimation of divergence dating. Two speciation rate shifts in Riccardia could be the results of asexual reproductive structure in this genus and climate changes in the Neotropics. Ecological conditions at the origin of the family and association with fungi might be associated with the increased diversification in this family.
Go beyond the limits of Genetic Algorithm in daily covariate selection practice
Authors: Ronchi Davide , Tosca Elena Maria , Bartolucci Roberta Bartolucci , Magni Paolo
Published: February 2023

Covariate identification is an important step in the development of a population pharmacokinetic/pharmacodynamic (PK/PD) model. Among the different available approaches, the stepwise covariate model (SCM) is the most used. However, SCM is based on a local search and on the assumption of independent covariate effects. Moreover, it is manly designed to test few covariate-parameter relationships, often chosen ad hoc or based on prior knowledge. The application of genetic algorithms (GA) for covariate selection has been proposed as a possible solution to overcome these limitations. However, their actual use during model building is limited by the extremely high computational costs and convergence issues, both related to the number of models being tested. In this paper, we proposed a new genetic algorithm for covariate selection to address these challenges. The GA was first developed on a simulated case study; then, its performances were evaluated on a real-world problem related to Remifentanil. The implemented GA showed good results both in terms of correctness of the selected model and fitness optimization, and it was able to outperform the SCM in both scenarios. Furthermore, the heuristics introduced to overcome the limitations affecting currently available GA approaches allowed to reduce convergence times, obtain replicable results, and limit the number of selected covariates.
Spatial pattern and influential factors for early marriage: Evidence from Bangladesh Demographic Health Survey Data 2017-18
Authors: Billah Md Arif , Khan Md. Mostaured Ali , Hanifi Syed Manzoor Ahmed , Islam M Mofizul , Khan Md. Nuruzzaman
Published: February 2023

Background
Early marriage is highly prevalent in Bangladesh. It is linked with a range of adverse outcomes, including maternal and child mortality. However, research on regional variations and factors associated with early marriage is scarce in Bangladesh. This study aimed to explore the geographical variations and predictors of early marriage in Bangladesh.
Methods
Data of women aged 20–24 in the 2017-18 Bangladesh Demographic and Health Survey were analysed. The occurrence of early marriage was the outcome variable. Explanatory variables were several individual-, household- and community-level factors. Geographical hot spots and cold spots of early marriage were first determined using Global Moran’s I statistic. Multilevel mixed-effect Poisson regression was used to determine the association of early marriage with individual-, household-, and community-level factors.
Results
Almost 59% of women aged 20–24 reported they were married before reached18. The hotspots of early marriage were mainly concentrated in Rajshahi, Rangpur and Barishal, and the cold spots were in Sylhet and Chattogram divisions. The prevalence of early marriage was lower among higher educated (adjusted prevalence ratio (aPR): 0.45; 95% CI: 0.40, 0.52), and non-Muslim women (aPR: 0.89; 95% CI: 0.79, 0.99) than their counterparts. Higher community-level poverty was significantly associated with early marriage (aPR, 1.16; 95% CI: 1.04, 1.29).
Conclusion
Early marriage is highly prevalent in Bangladesh. Promoting girls’ education, awareness-building programs about the adverse effects of early marriage and proper application of the child marriage restraint act, particularly in disadvantaged communities are recommended.
High Performance and Area Efficient Multi-Operand Binary Tree Adder
Authors: S SUTHAGAR
Published: February 2023

The building blocks of many digital systems like digital signal processors, microprocessors are the arithmetic units. Adders are the most important component in arithmetic processing unit. In recent times the multi operand adder (MOA) are used widely in signal and image processing applications because of its low power consumption, and it also reduces the partial sum and propagated carries. In this work multi operand binary tree adder is designed using EXOR-MUX based full adder. The proposed BTA gives an enhanced performance than the existing adder architecture which is designed based on AOI/OAI logic. The existing system takes more logic size because the OAI logic is implemented as the inverse of AOI logic. The functionality of the binary tree adder is verified using VERILOG HDL and synthesized using MODEL SIM 6.5 and XILINX ISE 14.7. The performance of the proposed binary tree adder is increased 44% with respect to area and 32% with respect to delay. Taking everything into account, the proposed BTAs outdo the existing BTAs.
Ein virtueller Laborrundgang – Gestaltung, Entwicklung und Evaluierung
Authors: Braun Christoph , Kayali Fares , Moser Thomas
Published: January 2023

Kleine und mittlere Unternehmen in Niederösterreich stehen aktuell vor der Herausforderung, dass oftmals nur wenig Zeit zur Weiterbildung aufgewendet werden kann. Obwohl Einrichtungen wie FabLabs oder MakerLabs zum Besuch von Workshops zu den Themen wie 3D-Druck oder Lasercutting in ihre Werkstätten und Labore einladen, sind die Einrichtungen zur Kompetenz- oder Wissensaneignung dennoch bei der Zielgruppe wenig bekannt. Daher wurde das Projekt DigiLabTour Ost gestartet mit dem Ziel, derartige Räume der Zielgruppe zeit- und ortsunabhängig in Form von virtuellen Besichtigungen zugänglich zu machen. Ziel ist es, ausgewählte Labore online und als didaktisches Szenario, bestehend aus Komponenten der Vermittlung, Aktivierung und Betreuung für die Lernenden aufzubereiten. Mit diesem Artikel wird anhand eines Praxisbeispiels, ein gestaltungsorientierter Forschungsprozess dargestellt und gezeigt, wie virtuelle Rundgänge als Lösung für ein praktisches Bildungsproblem konzeptioniert, produziert und evaluiert werden können. Als Ausgangsbasis dienen dabei bereits vorab definierte Gestaltungsfragen, die es im Kontext des Praxisbeispiels zu beantworten galt. Nach der Entwicklung und der Präsentation erster virtueller Rundgänge zeigte eine formative Evaluierung, dass die Webanwendung von der Zielgruppe positiv angenommen wird. Basierend auf der zielgruppenorientierten Interaktionsgestaltung sollen nun weiterführende Untersuchungen zur Integration von sequenzierten Animationen in virtuellen Rundgängen durchgeführt werden.
Knowledge of nurses on neonatal sepsis: a tertiary teaching hospital-based study
Authors: Qazi Mahvish , Mohammed Syed Muneeb , Saqib Najmus , Daraz Zahoor Hussain , Kumar Niraj
Published: January 2023

Neonatal sepsis is a significant cause of morbidity and mortality in hospitalized newborns and premature infants. Therefore, knowledge of essential newborn Care (ENC) is important for a newborn's survival, growth and development.

The aim of this study was to assess the knowledge of nurses regarding essential newborn care in our Special Care Neonatal Unit (SCNU).

Methods: A descriptive cross-sectional study was conducted between 1st September 2021 and 30th November 2021 among the nurses working in SNCU of Government Medical College and Hospital (GMC), Doda, Jammu and Kashmir, India. Data were was collected using a pre-tested questionnaire by purposive sample. Collected data were checked, and coding was done and analyzed using SPSS 20 software.

Results: 72.0 % of nurses were of the age group of 21–30 years. The majority (74 %) were females, 78 % had completed B Sc Nursing, and 66 % had experience of 2 to 4 years. Most of the nurses had good knowledge about ENC, about basic equipment’s used in SNCU, and about advanced equipment’s or procedures had less knowledge. All nurses answered bacteria correctly as a causative organism of neonatal sepsis.

Conclusions: Most of the nurses working in the SCNU of GMC Doda had good knowledge regarding ENC. The knowledge appeared irrespective of their age, gender, religion, educational status, working place and special courses/training in neonatology.
ST2 and copeptine – modern biomarkers for monitoring the effectiveness of treatment of decompensated heart failure in patients after acute myocardial infarction
Authors: Levandovska Khrystyna , Vakaliuk Ihor , Tymochko Natalia
Published: January 2023

The aim of the study was to increase the efficiency of diagnostic methods to find means to improve the treatment of patients with decompensated heart failure in the post-infarction period.
Materials and methods. This study is based on an examination of 120 patients with decompensated HF (60 patients with STEMI and 60 with non-STEMI). Patients with previous STEMI complicated by decompensated heart failure were divided into groups, depending on their treatment. The studied groups were homogeneous in terms of age, sex, the severity of the course of the disease, duration of the post-infarction period, and the presence of clinical manifestations of decompensation. The patients were observed on the first day after hospitalization, after 1 and 2 months after treatment. Copeptin serum levels were assayed using the EK 065-32, EIA Copeptine kit (RayBiotech, Inc., USA). ST-2 in blood serum was determined with the help of the Presage ST-2 kit (Critical Diagnostics, USA). The level of ST2 was determined in ng/ml.
Results. We analysed the effect of therapy on the level of ST2 in the blood serum of examined patients with STEMI and non-STEMI complicated by decompensated heart failure. All the treatment regimens we proposed led to a significant decrease in the level of this peptide in blood serum after the end of the treatment. In patients of group I who received basic therapy drugs, the average ST2 concentration was (49.47±1.77) ng/ml before treatment. After 1 and 2 months of therapy, it was (44.92±1.22) ng/ml and (41.67±1.18) ng/ml, respectively (p˂0.05). The patients with decompensated heart failure after non-STEMI from group I had a copeptin level of (18.13±0.10) pg/ml before treatment and probably decreased to levels of (16.29±0.15) pg/ml and (15.09±0.14) pg/ml after 1 and 2 months under the influence standard therapy.
Conclusions. We found the dependence of copeptin and ST2 levels on decompensated HF in the early and late post-infarction periods. It was established that the use of the therapy with a combination of the studied drugs led to a more intense decrease in serum copeptin, compared to therapy with succinic acid, arginine drugs, and standard therapy (p˂0.05). Using a differentiated treatment algorithm for patients with decompensated heart failure in the post-infarction period, copeptin and ST2 in blood serum increases the effectiveness of treatment and prevents complications.
Modern concepts of teeth whitening – a narrative review
Authors: Boitsaniuk Svitlana , Kochan Orest , Levkiv Mariana
Published: January 2023

Whitening has been known since Biblical times. Nowadays, in the developed world, patients are placing a stronger interest in the aesthetic appearance of their teeth. As a result, public demand for aesthetic dentistry, including tooth whitening, has recently increased. Aesthetics of the teeth is of great importance to many patients.
The aim is to summarise and discuss the teeth whitening procedure, tools, materials, and methods, as well as its efficacy and safety. In addition, the paper aims to provide full and comprehensive information for dentists and their patients about the merits and perils of whitening.
Methods. Relevant literature from Scopus published in English was selected using the following search criteria "tooth OR teeth AND whitening OR bleaching" by 2022. In total, there were found 3840 papers. Then, we applied the inclusion and exclusion criteria to the selected scientific papers to choose the relevant ones.
Results. A comprehensive study of the available information related to means and products for teeth whitening was carried out. Whitening may be accomplished by the physical removal of the stain or a chemical reaction to lighten the tooth colour. The indications for appropriate use of tooth-whitening methods and products depend on the correct diagnosis of the discolouration. When used appropriately, tooth-whitening methods are safe and effective.
Conclusions. Tooth whitening is a form of dental treatment and should be completed as part of a comprehensive treatment plan developed by a dentist after an oral examination.
Prediction of one-year adverse clinical outcomes by macrophage migration inhibitory factor in stemi patients
Authors: Vyshnevska Iryna , Storozhenko Tatyana , Kopytsya Mykola , Bila Natalia
Published: January 2023

Biomarkers have taken one of the first places as diagnostic and prognostic tools in ST-segment elevation myocardial infarction (STEMI) and are consequently widely used as predictors of short-term and long-term prognosis. One of the promising biomarkers for early cardiovascular outcomes prediction is the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF).

The aim of the study was to elucidate a plausible predictive value of the MIF levels for one-year clinical outcomes in STEMI patients who underwent primary percutaneous coronary intervention (PCI).

Materials and methods. 134 STEMI patients were enrolled in the study after receiving voluntary informed consent. All patients underwent conventional investigations, and additionally, the MIF levels were determined at baseline, directly before and after PCI. During 1-year follow-up, 37 % of patients reached the endpoint, which was composite and included all-cause mortality, non-fatal myocardial infarction, non-fatal stroke, hospitalization for unstable angina, heart failure decompensation, and urgent revascularization.

Results. We have found that pre-PCI MIF levels > 3934 pg/mL (AUC=0.7; 95 % CI 0.578 to 0.753; Youden index=0.31; p=0.008) might be an independent predictor of composite endpoints with sensitivity 54 % and specificity 82 %. A positive correlation between MIF and inflammatory biomarkers was revealed (WBC count r=0.33, p=0.0001; CRP r=0.19, p=0.032). Adverse outcomes associated with higher pre- and post-PCI MIF levels (OR 1.0, 95 % CI 1.0001–1.0008; p=0.013 and OR 1.0, 95 % CI 1.0001–1.0009; p=0.019) and CRP that determined during the first week after the event (OR 1.0, 95 % CI 1.005–1.2, p=0.03). Kaplan-Meier analysis has shown a substantially lower long-term survival rate in patients with a MIF level > 3493 pg/ml compared to a MIF level ≤ 3493 pg/ml (Log rank=0.00025).

Conclusions. The MIF levels exceeding 3934 ng/ml were associated with a higher risk of one-year adverse clinical outcomes in STEMI patients who underwent primary PCI.
Prevention of gastrointestinal diseases in piglets at weaning using probiotics Bacillus coagylans and Bacillus megaterium
Authors: Bakun Yuliia
Published: January 2023

The aim of the study is to determine the preventive effect of the use of probiotics Bacillus coagulans and Bacillus megaterium in case of gastrointestinal diseases in piglets and as a potential strategy to reduce the misuse of antibiotics in monogastric animals by adding probiotics to the diet of pregnant sows and piglets in the period before and after weaning.

Materials and methods. Three research groups were formed to study the preventive effect of probiotics of the genus Bacillus coagulans and Bacillus megaterium. The piglets of the first experimental group received probiotics at the rate of 0.4 kg per 1 ton of feed in the periods before and after weaning, and that is, the moment of the entire study, the second experimental group received probiotics in the period after weaning, before that they received milk from the sow. The third group was the control group, which received only milk from the sow, and fodder during the weaning period. The effectiveness of the prevention result was determined by the absence/presence of clinical signs of morbidity and % survival of animals during the study period.

The results. It was established that the preservation of livestock in the 1st experimental group was 90 %, and in the 2nd group – 70 %, and control – 50 %.

Conclusions. Research results show that probiotics of the genus Bacillus coagulans and Bacillus megaterium, the components of which provide a wide spectrum of antimicrobial activity, are a reliable preventive measure for gastrointestinal diseases in piglets.
Surgical treatment of acute complicated duodenal ulcer
Authors: Bilyachenko Maxim , Kurbanov Anton , Povch Oleg
Published: January 2023

The aim. To analyze treatment approaches and tactics and improve acutely complicated duodenal ulcers (DU) treatment results.

Materials and methods. The results of the analysis of the surgical treatment of acutely complicated duodenal ulcers (a combination of 3 and/or 4 combined complications) are presented for 2 periods: the 1st (2000–2014) years (group A) – 47 patients, the 2nd (2015–2021) years (group B) – 34 patients.

Results. 81 (100 %) patients were operated on for acutely complicated duodenal ulcers, of which 68 (84.3 %) patients had a combination of three complications, and 13 (15.7 %) had four complications. Out of 81 patients, 72 had bleeding complications, which is 89.3 %. Complications of ulcer perforation – in 36 patients, 44.7 % of all other complications.

Based on the obtained analysis data, there is a steady trend towards an increase in the share of organ-sparing operations (OSO) by 1.6 times (from 50.9 % to 81.4 %), a decrease in the number of gastric resections (GR) by 2.9 times (from 14.9 % to 4.9 %) and palliative operations (PO) by 3.2 times (from 15.8 % to 4.9 %) with a relatively stable number of performed organ-preserving operations (OPO): in group A – 17 (24 .6 %) interventions, in group B – 4 (21.1 %).

Conclusions. The use of modern measures of endoscopic hemostasis made it possible to adequately prepare and operate on patients in the delayed period, and their share from the first period to the second increased by 2.9 times.

The number of patients who underwent emergency surgery with ulcer perforation and bleeding as combined complications decreased in the second period compared to the first by 2.5 times, which is associated with the widespread use of modern proton pump inhibitors (PPIs) in the conservative treatment of DU.

The number of complications and mortality of this cohort of patients also significantly decreased due to the use of endoscopic hemostasis methods, making it possible to stabilize and prepare patients on the operating table.

According to the analysis results, it became known that the chosen active-individualized tactics and the use of developed algorithms for choosing the type of surgical intervention made it possible to achieve a stable level of postoperative mortality at 8.1 %.
Relationship between maternal abo blood group and rh typing with maternal and perinatal outcome
Authors: Devi Arukonda Niranjani , Pathri Manjula , Tammala Sruthi
Published: January 2023

The ABO blood group type has been considered an independent risk factor in pregnancy-related complications leading to significant morbidity and mortality in pregnant mothers and neonates.

Aim: To study the relationship between maternal ABO blood group and Rh typing with maternal and perinatal outcomes.

Materials and methods: Prospective Observational study was carried out for 24 months from November among 1000 pregnant women attending outpatient for ABO blood group and Rh typing with maternal and perinatal outcome.

Results: Among 1000 subjects, 43.5 % belonged to blood group O, followed by 30 % in blood group B. 20.7 % had blood group A, and 5.8 % had AB blood group. In the present study, 95.4 % had Rh+ve, and 4.6 % had Rh-ve typing. The incidence of preterm labour was high at 6.3 % in the O+ve blood group, followed by 1.8 % in the AB +ve, 0.6 % in the A+ve and 0.3 % in the B+ve blood group. A statistically significant association was found between blood grouping and preeclampsia with high incidence among the A+ve blood group. A statistically significant association was found between blood grouping and imminent eclampsia with high incidence among the AB+ve blood group. There was a statistically significant association found between blood grouping and intrauterine death.

Conclusion: The findings in the present study will help clinicians to identify the patients at risk of developing adverse pregnancy outcomes like preeclampsia and imminent eclampsia; hence, the timely intervention will help to improve maternal and perinatal outcome and also helps to reduce the complications of preeclampsia and imminent eclampsia.
Cross-sectional study to evaluate various cardiovascular manifestations in pregnant women with preeclampsia using 2d echocardiogram
Authors: Devi Lakshmi , Banerjee Preet , Durga D. V. K. , Sahu Pooja
Published: January 2023

Preeclampsia is one of the most frequent complications found in pregnancy. Preeclampsia was initially thought to cause poor long-term cardiovascular outcomes, but recent studies have shown its effect to be more early and severe.

Aims: To reduce the morbidity and mortality for all patients with hypertension in pregnancy through any cardiovascular problem that is directly caused by hypertension in pregnancy

Methods: it is a cross-sectional and observational study of pregnant women with preeclampsia in the reproductive age group (15–44 years) diagnosed with preeclampsia in the antenatal ward/HDU/MICU at Niloufer hospital were evaluated with 2d echo on diagnosis and a follow up 2d echo after delivery was done and changes in 2d echo were noted, patients with prior changes in 2d echo have been excluded from the study. About 113 preeclamptic patients were studied and further classified as non-severe and severe preeclampsia, and their results were compared.

Results: This study shows significant cardiovascular dynamics changes in subjects with preeclampsia (both severe and non-severe) which can be studied by 2 D echo. Non-severe preeclampsia was associated with more normal birth weight. This was found statistically significant in our study. IUD and early neonatal death were more associated with severe preeclampsia when compared to non-severe preeclampsia, which was found statistically significant.

Conclusions: Early identification of preeclamptic patients at higher risk of developing cardiovascular complications later in life by undergoing timely echocardiography.
Safety of domestic ferries: a scoping study of seven high-risk countries
Authors: Hebbar Anish , Schröder-Hinrichs Jens-Uwe , Yildiz Serdar , Kahlouche Nadhir
Published: February 2023

Ferry accidents are fairly common globally, causing countless deaths and injuries. Whereas ferry transportation is an integral part of the domestic transport infrastructure in many countries, particularly archipelagic countries such as Indonesia and the Philippines, river deltaic countries like Bangladesh, countries with extensive riverine systems such as the Democratic Republic of the Congo, Nigeria and Senegal, or even a combination of great lakes, rivers and archipelago such as Tanzania, these countries are experiencing a high number of ferry accidents and fatalities over the past two decades and, therefore, considered high-risk countries in the ferry transport sector. International community continuously seeks to enhance safety in the domestic ferry industry. Thus, a scoping study has been conducted on the safety of domestic ferries in these seven high-risk countries. The study utilizes a structured methodology to identify focus areas in the seven countries for enhancing safety in the domestic ferry sector. The analysis involves past domestic ferry accidents, maritime profile, industry demographics and stakeholder matrix, regulatory and governance climate, political landscape, and amenability to change and external intervention. Eventually, the study proposes a conceptual framework with fifteen distinct criteria, identified against five attributes as an aid to the decision-making in a country for considering a safety intervention with a high likelihood of success and a significant positive impact on safety in the domestic ferry sector. Furthermore, current hazards threatening the safety of domestic ferries and their role in the formation of accidents; key stakeholders of domestic ferry sector and their state of play; national regulations related to the safety of domestic ferries and alignment with the IMO model regulations; national political landscape; state’s willingness to facilitate and receive a safety intervention; and public attitude towards safety are presented in the respective countries using globally recognized indices, questionnaire surveys and personal interviews.
optimization of a Bilih fish drying system using the technique for order preference by similarity to ideal solution (TOPSIS)
Authors: Parkhan Ali , Purnomo Hari , Hermawan V , Apsari Ayudyah Eka
Published: January 2023

The quality of dried Bilih fish can be determined on the basis of its water and protein content. The dried Bilih fish produced by Small Medium Enterprise (MSE) Mina Lestari has a high water content of 24% and a low protein content of 35%. These problems were addressed using a proposed parabolic-type drying machine, whose operating system is affected by drying duration, drying tray height, tray rotation, drying layer material and rack quantity and capacity. The results showed that water content decreased to 11.98% and that protein concentration increased to 64.02%. The sensitivity analysis indicated that changes in the values of quality attributes were minimally sensitive to alterations in the weights attached to water and protein content. The optimal combination of factor levels would remain consistent even under a weight of ≤0.83286 ascribed to water content, indicating that a weight ranging from 0 to 0.83286 for this substance exhibits little sensitivity to the initial decision on level factors.
Pakeliran Layar Lebar
Authors: Marajaya I Made
Published: January 2023

This study aims to describe the development model for Balinese shadow puppet shows in the era of globalization. For nearly thirty years, Balinese shadow puppet performances marked ups and downs of requests from the public to respond to and watch them, especially for traditional performances. For this reason, to restore the Balinese shadow puppets to revival in the era of globalization, young puppeteers try to save them by exploring, preserving, and developing shadow puppet shows by creating a new work called Pakeliran Layar Lebar. The work on Pakeliran Layar Lebar is one of the genres of traditional wayang art that has appeared since 1988 under the encouragement of Prof. Dr. I Made Bandem, who at that time was chairman of the Denpasar Indonesian Art College. Visually, the form of Pakeliran Layar Lebar is very much different from the traditional ones. In its presentation, dance artists, musicians, puppeteers, theatres, narrators, and interpreters supported Pakeliran Layar Lebar with advanced technology such as; lighting, scenery, sound system, computer, LCD, and so on also support. Pakeliran Layar Lebar is classified as a balih-alihan (spectacle) art, so it functions as a medium for education, entertainment, and artistic creativity with an aesthetic nuance.
The Current Concept and Role of Intensive Cardiovascular Care Units
Authors: Suridanda Danny Siska
Published: January 2023

Since its first establishment in the early 1960s, intensive care for the critically ill cardiac patients had transformed substantially. From a unit designed only to monitor cardiac rhythm and administer electrical therapy to patients with myocardial infarction (MI), the Intensive Cardiovascular Care Units (ICVCU) now provide care for a wide array of patients with cardiovascular conditions needing close observation and hemodynamic support. This shift in role is accompanied with the development of cardiac critical care as an emerging subspecialty of cardiovascular medicine. Cardiac intensivists should have proper training in general cardiology, combined with additional competency in critical care, including mechanical ventilation, renal replacement therapy, mechanical circulatory support and general preventive measures for infections. A high-intensity medical staffing in a closed care system had shown to improve mortality in critically ill cardiac patients in the contemporary ICVCUs. As interventional cardiology, structural heart disease, electrophysiology, advanced heart failure and transplantation continue to offer new treatment options for complex high-risk patients, cardiac critical care is of utmost importance to provide collaborative care among these disciplines.
Acute Decompensated Heart Failure: Current Role of Diuretics and Ultrafiltration
Authors: Arie Kurniawan Dea , Prasetya Indra , Widito Sasmojo , Martini Heny
Published: January 2023

Acute decompensated heart failure (ADHF) continues to be the leading cause of hospitalization and has a poor prognosis. Loop diuretic had been long used as cornerstone therapy for congestion and volume overload. However, several factors including diuretic resistance and declining renal function reduced the loop diuretic's effectiveness, necessitating a different treatment strategy. In ADHF, ultrafiltration (UF) could be a promising method to volume management. UF appears to be more effective at removing fluid than diuretics, according to several studies, with better quality of life and lower rehospitalization. This review highlights the current state of knowledge regarding the use of diuretics and UF in ADHF patients, as well as the challenges and questions raised associated with each approach.
Correlation Between NT pro-BNP, Troponin I and Inhospital Mortality in Miokard Akut Patients Who Have Already Undergone Percutaneous Coronary Intervention: a Report from ONE ACS Registry Subarea dr. Saiful Anwar Malang Hospital
Authors: Ivana sari Dyah , Anjarwani Setyasih , Rizal Ardian , Saifur Rohman Mohammad , Prasetya Indra
Published: January 2023

Introduction. Many research have looked into the potential of various biomarkers as predictors of intrahospital mortality in patients with STEMI. Patients with a history of heart failure, patients with STEMI with cardiogenic shock, and patients with heart failure all had a similar association between pro-BNP NT and intra-hospital mortality. In STEMI patients, troponin is another biomarker that can be utilized to predict intrahospital mortality with NT pro BNP. Objective. This study looked into the correlation between NT pro BNP and troponin I and intrahospital mortality in STEMI patients who had had PCI at RSUD dr. Saiful Anwar Malang. Material and Methods. A retrospective cohort research with an observational analysis design, targeted 391 STEMI patients who underwent PCI at RSUD dr. Saiful Anwar Malang between January 2018 and August 2022. Result. With AUC NT pro BNP 0.840 (95% confidence interval [CI]: 0.789 – 0.892) and troponin I AUC 0.818 (95% CI: 0.753 – 0.882), the ROC curve demonstrated a high degree of discriminating. The NT pro BNP 4390 cutoff value was also derived from the ROC analysis with a sensitivity of 0.882 and a specificity of 0.882. The threshold for troponin I was 7.9, with a sensitivity of 0.725 and a specificity of 0.80. From the examination of the connection, it was determined that there was a high link between NT pro BNP and intrahospital mortality in AMI EST patients who had had PCI, with a R value of 0.70; OR 10,484 (95% confidence interval [CI]: 7,731–19,366). With a R value of 0.4, there was a moderate connection between troponin I and intrahospital mortality in STEMI patients who had had PCI; the odds ratio was 6,167 (95% confidence interval: 2,286–16,637). Conclusion. There were a strong and moderate correlation between NT pro BNP and troponin I, respectively, with inhospital mortality in STEMI patient.
Acute Hemodynamic Index as a Predictor of In-Hospital Mortality in Mechanical Ventilated Acute Decompensated Heart Failure Patients
Authors: Arie Kurniawan Dea , Anjarwani Setyasih , Rizal Ardian , Satrijo Budi , Yogibuana Swastika Putri Valerinna
Published: January 2023

Background: The likelihood of a poor clinical outcome is significantly increased in patients with acute decompensated heart failure. Mechanical ventilation was necessary for 23% of ADHF patients receiving treatment. The simple parameters of blood pressure and heart rate have good accuracy and repeatability. The development of the Acute Hemodynamic Index allowed for the calculation of pulse pressure and heart rate to be used as a basis for predicting intrahospital mortality. Methods: The medical records of patients who received care at CVCU RSSA were used in this retrospective, single-center study. ROC analysis and multivariate regression analysis were used to evaluate the prognostic performance of AHI. Statistical significance was determined by the P value of 0.05 or lower. Results: 252 patients with heart failure and low ejection fraction had their data analyzed. Hospital mortality is 82 percent. The cut-off was 4.19 mmHg/bpm, which was the AHI value. 68.8% of patients with fatal illnesses had low AHIs ( 4.19 mmHgbpm). AHI > 4.19 mmHgbpm patients have a 9-fold increased risk of dying in the hospital than patients with low AHI. AUC: 0.825 [0.743-0.907]; sensitivity: 0.814; specificity: 0.689; AUC: 0.825 [0.743-0.907; p = 0.000]; demonstrate the high predictive power of AHI. Conclusion: AHI has a strong degree of association with the likelihood of dying in the hospital from acute decompensated heart failure.
Risk Factors for Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Apriditya Yudi , Satrijo Budi , Anjarwani Setyasih , Prasetya Indra , Fuji Rahimah Anna
Published: January 2023

Background Acute Kidney Injury (AKI) is a prominent complication of ACS, is more prevalent in STEMI, and can be a predictive indicator of long-term death. The frequency of AKI in patients with STEMI ranges between 10 and 20 percent, and the presence of AKI has a significant impact on in-hospital clinical results and long-term outcomes. Aim Form the basis for clinical considerations for the cost-effectiveness of treating STEMI with Acute Kidney Injury after undergoing primary percutaneous coronary intervention (PCI). Methods This cohort retrospective study of 597 STEMI patients who underwent Primary PCI from 2017 to July 2022 at Saiful Anwar General Hospital Malang. There were 568 patients included, 29 patients were excluded. We conducted both univariate and multivariate studies to determine AKI risk factors. By comparing the area under the curve, the receiver operating characteristic curves were compared (AUC). The number of positive variables for which the sensitivity and specificity were established. Using SPSS 26.0, data were examined. Results In terms of familial CAD risk factors, there was a statistically significant difference between the two patient groups with p= 0.020. In the clinical condition of shock (p = 0.000); IMA location p = 0.019; Killip classification (p = 0.000). The laboratory parameters that are significant between the two groups to be a risk factor for incidence of acute kidney injury include Random Blood Sugar (RBS) with p value = 0.000. The results of cardiac catheterization in culprit lesions showed significant results for the incidence of AKI in STEMI patients undergoing primary PCI with p-value = 0.000; TIMI flow (p = 0.000); and total volume contrasts (p = 0.000). This variable, with p value < 0.05, is an independent risk factor for the incidence of AKI in STEMI patients undergoing primary PCI. Furthermore, multivariate analysis with logistic regression was performed on these variables. From multivariate analysis with logistic regression, result of the odds ratio value (OR) of each variable was obtained for the incidence of AKI. The OR values for each were as follows: Shock condition (OR = 1.41; 95% CI 1.18 – 1.92); Killip 3 (OR = 3.54; 95% CI 2.14 – 4.26); LAD culprit lesions (OR = 0.34; 95% CI 0.27 – 0.68); and total volume contrast > 145 ml (OR = 1.61; 95% CI 1.13 – 1.92). Based on the ROC curve above, the total volume contrast > 145 ml is independent risk factor with an Area under curve (AUC) of 0.75 (95% CI 0.65-0.85); a sensitivity of 0.71 (95% CI 0.0.65-0.76) and a specificity of 0.66 (95% CI 0.61 – 0.71 ).
Perioperative Myocardial Infarction After Coronary Artery Bypass Grafting: How to Identify?
Authors: Ivana Sari Diah , Anjarwani Setyasih , Rizal Ardian
Published: January 2023

Introduction. Perioperative myocardial infarction (PMI) associated with the surgical revascularization (CABG) occurs in about 3–5% of patients. Myocardial necrosis and ischaemia after CABG are caused by direct cardiac trauma from manipulation, reperfusion injury, incomplete revascularization, hypotension, bleeding, ventricular arrhythmia, acute graft closure, inadequate perioperative myocardial protection and others. Case report. The introduced case report explains the rupture of right ventricle result in periprocedural myocardial infarction following the surgical myocardial revascularization. 62-year-old man has undergone the coronary bypass surgery with arterial graft of left mammary artery (LIMA) to left anterior descending artery (LAD) and savenous graft to left circumflex coronary artery (LCx). Early in the post-surgery period a perioperative myocardial infarction (PMI) developed, with laboratory correlation of cardio-specific enzymes elevation and ECG changes in terms of ischaemia in the diaphragmatic region. Echocardiography showed akinesia of the apex, apical septal and apical inferior segments accompanied by the decrease in ejection fraction (EF) of the left ventricle. Conclusion. Early detection of PMI may therefore, prompt institution of therapeutic measures to relieve the ischaemia and decrease the incidence and the size of PMI
Ventricular Tachycardia Storm Management in Acute Cardiac Care: Prompt response to life-threatening conditions
Authors: Lestari Puspa , Anjarwani Setyasih , Saifur Rohman Mohammad , Rizal Ardian
Published: January 2023

Background: Ventricular Tachycardia (VT) storm or electrical storm (ES) is defined as cardiac electrical instability and refers to the occurrence of three or more ventricular tachyarrhythmias (VT and or ventricular fibrillation (VF)) in a 24-hour period, or VT recurring soon (within five minutes) after termination of another VT episode, or sustained or no sustained VT with total ectopic beats greater than sinus beats in a 24-hour period. The frequency of VT storms varies on population. When ICDs are implanted for primary prevention (4 percent), it is lower than when they are implanted for secondary prevention (20 percent). Case Summary: We presented patient with Ventricular Tachycardia (VT) storm. A 63-year old woman was admitted to emergency room with chief complaint frequent episodes of palpitation. She was found to have monomorphic VT with unstable hemodynamic. Then she got cardioversion 100 Joule, continued with lidocaine drip and VT reverted to sinus rhythm. Patient admitted to cardiovascular care unit, but she had VT refractory. She got complete revascularization for coronary artery before, but the episodic of VT still occurred with cardiogenic shock (CS) and pulmonary edema. She got cardioversion, amiodarone iv and inotropes, then observed this patient at CVCU. After the condition stable, this patient was discharged and planned for ICD insertion at the next admission. Discussion: We discuss the various available treatment options for VT storm and practical challenges faced in management of hemodynamically unstable VT storm. Initial management involves identifying and correcting the underlying ischemia, electrolyte imbalances, or other inciting factors.
Acute Myocardial Infarction in a 25-Years-Old Male: Understanding the Risk and Comprehensive Management
Authors: Galih Ardhani , Tri Tjahjono Cholid , Widito Sasmojo , Ruspiono Evit
Published: January 2023

Acute coronary syndrome (ACS) in young adults is a rare entity, yet it occurs. We present a case of a man 25 years old with no history of certain diseases, suddenly come up with ST elevation myocardial infarct. Young patients have different risk factors, clinical features and prognosis as compared to elderly patients. The diagnosis of ACS is also often overlooked in this subset of population. Furthermore, it constitutes an important problem because of the devastating effect of this disease on the more active lifestyle of young adults. This case report was an attempt to look for the risk factors most prevalent in young patients and its management prior and during the hospital stay.
Hábitos forrajeros de Ammotragus lervia (Pallas, 1777) (Artiodactyla: Bovidae) en matorral desértico rosetófilo de Coahuila, México
Authors: Gastelum-Mendoza Fernando Isaac , González-Saldívar Fernando Noel , Lozano-Cavazos Eloy Alejandro , Uvalle-Sauceda José Isidro , Serna-Lagunes Ricardo , Cantú-Ayala César Martín
Published: February 2023

El borrego berberisco (Ammotragus lervia Pallas, 1777) es un herbívoro exótico considerado una especie invasora en el noreste de México del que no se conocen los efectos de la herbivoría sobre la vegetación nativa y la competencia con los ungulados nativos. El objetivo del estudio fue identificar la composición y diversidad estacional de la dieta de una población de A. lervia en la UMA Rancho San Juan, municipio de Monclova, Coahuila, México. Durante el periodo octubre 2018-agosto 2019, se establecieron líneas donde se recolectaron, procesaron y clasificaron las muestras fecales, y se generó un catálogo fotográfico de estructuras celulares vegetales de las plantas presentes en el hábitat. Mediante la técnica microhistológica se identificaron las especies de plantas consumidas y se clasificaron por estación: otoño (octubre 2018), invierno (febrero 2019), primavera (mayo 2019) y verano (agosto 2019), y forma biológica (arbustivas, herbáceas, pastos y suculentas). La dieta se expresó en frecuencia relativa con base en el cuadro de Fracker y Brischle. La diversidad de la dieta se estimó con el índice de Shannon. En la dieta de A. lervia se identificaron 64 especies y 21 familias, siendo las familias Poaceae (15), Fabaceae (9 spp.), Asteraceae (8 spp.) y Euphorbiaceae (7 spp.) las más representativas. Asimismo, Vachellia rigidula, Tiquilia canescens, Medicago sativa y Opuntia engelmannii, representaron en conjunto el 46.49 % de la dieta. En el año, la dieta se conformó de 36 % de plantas de porte arbustivo, 30 % herbáceas, 22 % pastos y 12 % suculentas. En primavera predominaron las arbustivas (54.80 %), en verano e invierno las herbáceas (46.39 y 37.90 %, respectivamente) y en otoño los pastos (35.19 %). La diversidad de la dieta fue H’ = 2.89 ± 0.13 especies, mayor a lo reportado en su hábitat natural. La composición de la dieta de A. lervia fue similar a lo reportado para otros herbívoros silvestres de matorrales desérticos en México y Estados Unidos, esto implica una condición de traslape de dieta, pero se requieren de más estudios sobre dieta de herbívoros simpátricos del noreste de México.
Bibliometric analysis of entrepreneurial competencies using Scopus data and VOSviewer
Authors:   Information System, Faculty of Management, University Teknologi Malaysia, Johor Bahru, Malaysia, Manickam Mangair Karasi , Abd Rozan Mohd Zaidi ,   Information System, Faculty of Management, University Teknologi Malaysia, Johor Bahru, Malaysia
Published: January 2023

The positive impact of entrepreneurial competencies has sparked the attention of researchers from various industries and disciplines. Since academic scholars are becoming more interested in the practice of entrepreneurial competencies, thus it is required to gain a better grasp of the themes of interest and to expand collaboration networks in order to advance research toward interdisciplinary approaches. Therefore, an analysis using the bibliometric technique was conducted to find major trends and themes by analyzing significant papers, countries, authors, and keywords. This research used the Scopus database and expanded to scientific mapping using VOSviewer to provide a complete view of research trends. According to the statistics, the overall number of articles has climbed consistently from 2017 to 2021. Researchers from India, Malaysia, and the United Kingdom greatly contributed to the entrepreneurial competencies research. However, entrepreneurial competencies have received limited attention in the computer science and engineering field. The statistical research shows conclusively that there is a strong relationship between entrepreneurial competencies and intention, entrepreneurship education, and learning. The following analyses were accomplished in this study namely co-citation, bibliographical coupling, authors’ keywords, and co-occurrence of all keywords. Future researchers investigating entrepreneurial competencies will be able to accurately target their research using the findings presented in this paper.