bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoconfinement – amplified, Förster resonance energy transfer in nile red – borne mesoporous silica for ultrasensitive, multiplex assay of triphenylmethane dyes in aqueous milieu
Authors: Chen Yifan , Ye Sijian , Cheng Chongling , Xie Renguo , Wang Dayang
Published: September 2022

Mesoporous silica is utilized for sub-ppb-level Förester resonance energy transfer-based detection of triphenylmethane dyes in water.
Chitosan-based oxygen-doped activated carbon/graphene composite for flexible supercapacitors
Authors: Ren Ruquan , Zhong Yan , Ren Xueyong , Fan Yongming
Published: September 2022

An activated carbon/graphene hydrogel for supercapacitors was prepared by using chitosan-based activated carbon and graphene oxideviaa hydrothermal process.
Characterization of an aged alkali-activated slag roof tile after 30 years of exposure to Northern Scandinavian weather
Authors: Luukkonen Tero , Yliniemi Juho , Walkley Brant , Geddes Daniel , Griffith Ben , Hanna John V. , Provis John L. , Kinnunen Paivo , Illikainen Mirja
Published: September 2022

The phase assemblage and nanostructural characterization results reported here further elucidate the long-term changes occurring in alkali activated blast furnace slag binders.
Structure, magnetism and magnetocaloric effect in a new triangular lattice compound Gd3Cu9(OH)19Br8
Authors: Cheng Dong-Er , Wang Yi-Yan , Sun Yan , Liang Hui , Wu Dan-Dan , Li Qiuju , Sun Xuefeng , Yue Xiao-Yu
Published: September 2022

The two-dimensional magnetic lattice of Gd3Cu9(OH)19Br8, where Gd3+ ions are located in the center of hexagonal holes of the Cu-Kagome lattice.
Spontaneous organization and phase separation of skyrmions in chiral active matter
Authors: Li Zhong-Yi , Zhang De-Qing , Lin Shao-Zhen , Góźdź Wojciech T. , Li Bo
Published: September 2022

Chiral active matter capable of self-rotation can form skyrmions, which spontaneously organize into lattices or undergo dynamic phase separation, dependent on the competition between the chiral and polar coherence length scales.
Hollow NiO/carbon pompons for efficient lithium ion storage
Authors: Xiao Ming-Jun , Ma Bo , Zhang Hong , Li Xiang-Yang , Wang Qiang , Peng Yong , Zhang Hao-Li
Published: September 2022

Hollow pompon-like NiO/NDC was synthesized by ionic liquid assisted two step synthesis. When applied in lithium ion batteries, the hollow pompon-like NiO/NDC shows excellent reversible capacity and cycle performance.
Telepractice Evaluations With Children Who Are Deaf/Hard of Hearing: A Clinical Approach for Early Intervention Speech-Language Pathologists
Authors: Noss Emily , Sanderson Autumn
Published: September 2022

Purpose:

With the onset of the coronavirus disease 2019 (COVID-19) pandemic, speech-language pathologists (SLPs) who specialize in working with children who are deaf/hard of hearing continued to provide diagnostic services to the birth-to-3 population. Families' needs for this type of service did not stop while “safer at home” orders were in place. In March 2020, the nation was shut down, and in-person services came to a screeching halt. The purpose of this clinical focus article is to outline the procedures adapted by our clinical team, which allowed our SLPs to continue to meet the needs of families when in-person services were not available. The value in these adaptations was meaningful and continues to aid our ability to better serve families who may not be candidates to physically attend clinical appointments.

The COVID-19 pandemic challenged clinicians to adapt initial evaluation services and led to many questions that needed to be answered to continue serving children with a newly diagnosed hearing loss. Several strategies for providing services to families during the early intervention years via telepractice will be discussed. The clinical approach to decision making and methods utilized by our providers and graduate student clinicians, including the virtual meeting platform, correspondence and preparation with the family, assessment protocols, clinical recommendations, and parent guidance/counseling resources, will be outlined.

Conclusions:

The success observed using this clinical approach to initial evaluations and telepractice is notable. This clinical note is an effort to distribute the process to other SLPs and is considered necessary. The successful adaptations implemented have allowed clinic provision for our birth-to-3 population to thrive. Despite several identified barriers, telepractice will continue to evolve and be a vital service delivery model in the future. This article describes the overall processes implemented for SLP diagnostics using the telepractice service delivery model.
Compact low‐cost W‐band large‐scale high‐gain circular‐aperture slot array antenna
Authors: Qi Shishan , Zhao Junjie , Wu Wen
Published: September 2022

Based on substrate‐integrated waveguide (SIW) antenna technology, a compact high‐gain slot array is proposed in this paper. The proposed antenna is suitable for designing circular aperture and large‐scale array in W‐band. A method of dividing the array into multiple sections is proposed, which provides a solution for widening the bandwidth of large‐scale SIW slot arrays. The proposed antenna is composed of the backside waveguide feeding network and the upper SIW array. A novel method of loading biased metal vias on SIW is proposed to realize unequal power distribution. And it makes the antenna array to be compact, low‐cost, and easy to manufacture. An antenna prototype is fabricated and measured. The measured bandwidth of the antenna array is 92.2–96.2 GHz within |S11|<−10 dB, and the measured maximum gain is 31.8 dBi at 94 GHz, which correspond to the radiation efficiency and aperture efficiency of 27.5% and 15.7%, respectively. The proposed antenna is an excellent candidate for millimetre‐wave radar applications.
Communication, sensing, computing and energy harvesting in smart cities
Authors: Liu Yusha , Yang Kun
Published: September 2022

A smart city provides diverse services based on real‐time data obtained from different devices deployed in urban areas. These devices are largely battery‐powered and widely placed. Therefore, providing continuous energy to these devices and ensuring their efficient sensing and communications are critical for the wide deployment of smart cities. To achieve frequent and effective data exchange, advanced enabling information and communication technology (ICT) infrastructure is in urgent demand. An ideal network in future smart cities should be capable of sensing the physical environment and intelligently mapping the digital world. Therefore, in this paper, we propose design guidelines on how to integrate communications with sensing, computing and/or energy harvesting in the context of smart cities, aiming to offer research insights on developing integrated communications, sensing, computing and energy harvesting (ICSCE) for promoting the development ICT infrastructure in smart cities. To put these four pillars of smart cities together and to take advantage of ever‐increasing artificial intelligence (AI) technologies, the authors propose a promising AI‐enabled ICSCE architecture by leveraging the digital twin network. The proposed architecture models the physical deep neural network‐aided ICSCE system in a virtual space, where offline training is performed by using the collected real‐time data from the environment and physical devices.
KIC 6951642: A confirmed Kepler γ Doradus – δ Scuti star with intermediate to fast rotation in a possible single-lined binary system
Authors: Samadi-Ghadim A. , Lampens P. , Gizon L.
Published: September 2022

Context. KIC 6951642 has been reported as a candidate hybrid pulsator of type-γ Doradus – δ Scuti from observations of the first quarters of the Kepler mission. The regular patterns seen in the Fourier spectra of the Kepler and Transiting Exoplanet Survey Satellite TESS light curves and the sinusoidal modulation of its surface brightness suggest the additional presence of rotational modulation and stellar activity, respectively.

Aims. We aim to investigate the pulsating nature of KIC 6951642 and to search for the signature of rotation and/or activity in the light curves.

Methods. We performed an iterative frequency search of both Fourier spectra, and searched for regular patterns in them. We applied spectrum synthesis to determine the atmospheric stellar parameters. Since KIC 6951642 was reported to belong to a spectroscopic binary system, we fitted the time delays derived from the light curves with the radial velocities obtained from published as well as new spectra in an attempt to improve the quality of the first orbit.

Results. Follow-up spectroscopy showed that KIC 6951642 is a fast-rotating F0-type star in a possible single-lined binary with a period of ∼4.8 yr. In the low-frequency regime, we identified the frequencies of 0.721 d−1 as well as of 0.0087 d−1. We attribute the first frequency to stellar rotation, and the second one to stellar activity with a cycle of length of 3.2 yr. We also detected g modes, with the strongest mode located at 2.238 d−1, as well as three asymmetric multiplets (with a mean spacing of 0.675 ± 0.044 d−1). In the high-frequency regime, we detected frequencies of type-δ Scuti, with the strongest mode located at 13.96 d−1, as well as seven asymmetric multiplets (with a mean spacing of 0.665 ± 0.084 d−1). We subsequently identified a few more frequencies that appear to be combinations of a g or p mode and one of the higher cited frequencies not due to pulsations.

Conclusions. We propose that KIC 6951642 accomadates for a fast-rotating γ Dor – δ Sct hybrid star with various rotationally split multiplets of g and p modes and that it also displays a cycle lasting years of (possible) stellar activity.
A photochemical model of Triton’s atmosphere paired with an uncertainty propagation study
Authors: Benne B. , Dobrijevic M. , Cavalié T. , Loison J.-C. , Hickson K. M.
Published: September 2022

Context.The largest satellite of Neptune, Triton, is a likely Kuiper Belt object captured by the planet. It has a tenuous nitrogen atmosphere, similar to that of Pluto, and it may be an ocean world. The Neptunian system has only been visited once: by Voyager 2 in 1989. Over the past few years, the demand for a new mission to the ice giants and their systems has risen. Thus, a theoretical basis upon which to prepare for such a mission is needed.

Aims.We aim to develop a photochemical model of Triton’s atmosphere with an up-to-date chemical scheme, as previous photochemical models date back to the post-flyby years. This purpose is to achieve a better understanding of the mechanisms governing Triton’s atmospheric chemistry and to highlight the critical parameters that have a significant impact on the atmospheric composition. We also study the model uncertainties to find what chemical studies are necessary to improve the modeling of Triton’s atmosphere.

Methods.We used a model of Titan’s atmosphere and tailored it to Triton’s conditions. We first used Titan’s chemical scheme before updating it to better model Triton’s atmospheric conditions. Once the nominal results were obtained, we studied the model uncertainties with a Monte Carlo procedure, considering the reaction rates as random variables. Finally, we performed global sensitivity analyses to identify the reactions responsible for model uncertainties.

Results.With the nominal results, we determined the composition of Triton’s atmosphere and studied the production and loss processes for the main atmospheric species. We highlighted key chemical reactions that are most important for the overall chemistry. We also identified some key parameters that have a significant impact on the results. The uncertainties are high for most of the main atmospheric species since the atmospheric temperature is very low. We identified key uncertainty reactions that have the greatest impact on the result uncertainties. These reactions must be studied as a priority in order to improve the significance of our results by finding ways of lowering these uncertainties.
A fully-decoupled discontinuous Galerkin approximation of the Cahn–Hilliard–Brinkman–Ohta–Kawasaki tumor growth model
Authors: Zou Guang-an , Wang Bo , Yang Xiaofeng
Published: September 2022

In this article, we consider the Cahn–Hilliard–Brinkman–Ohta–Kawasaki tumor growth system, which couples the Brinkman flow equations in the porous medium and the Cahn–Hilliard type equation with the nonlocal Ohta–Kawasaki term. We first construct a fully-decoupled discontinuous Galerkin method based on a decoupled, stabilized energy factorization approach and implicit-explicit Euler method in the time discretization, and strictly prove its unconditional energy stability. The optimal error estimate for the tumor interstitial fluid pressure is further obtained. Numerical results are also carried out to demonstrate the effectiveness of the proposed numerical scheme and verify the theoretical results. Finally, we apply the scheme to simulate the evolution of brain tumors based on patient-specific magnetic resonance imaging, and the obtained computational results show that the proposed numerical model and scheme can provide realistic calculations and predictions, thus providing an in-depth understanding of the mechanism of brain tumor growth.
Asymptotic derivation of multicomponent compressible flows with heat conduction and mass diffusion
Authors: Georgiadis Stefanos , Tzavaras Athanasios E.
Published: September 2022

A Type-I model of a multicomponent system of fluids with non-constant temperature is derived as the high-friction limit of a Type-II model via a Chapman-Enskog expansion. The asymptotic model is shown to fit into the general theory of hyperbolic-parabolic systems, by exploiting the entropy structure inherited through the asymptotic procedure. Finally, by deriving the relative entropy identity for the Type-I model, two convergence results for smooth solutions are presented, from the system with mass-diffusion and heat conduction to the corresponding system without mass-diffusion but including heat conduction and to its hyperbolic counterpart.
Régulation de la pression artérielle
Authors: Fardol Dicken , Gulmez Aylin , Yoldas Zeynep , Lourdel Stéphane
Published: September 2022

Le Master de Biologie intégrative et physiologie (BIP) de Sorbonne Université recouvre un large champ disciplinaire, allant de la biologie du vieillissement à la physiopathologie, à la nutrition, aux bioressources marines et aux neurosciences, dont les enjeux sont essentiels aussi bien sur le plan fondamental qu’appliqué.

L’objectif de la mention est de former des spécialistes de haut niveau aux concepts les plus récents de la biologie intégrative. La mention forme les étudiants à appréhender les mécanismes qui sous-tendent les différentes fonctions physiologiques et pathologiques depuis la cellule jusqu’à l’organisme, chez les animaux ou dans l’espèce humaine.
Effect of cooling rate on the microstructures of three low carbon alloys with different manganese and molybdenum contents
Authors: Benarosch Anna , Marini Bernard , Toffolon-Masclet Caroline , Trzaska Zofia , Meslin Estelle , Guillot Ivan
Published: September 2022

Low-alloy 16 to 20MND5 steels are used for the production of nuclear reactor components. During manufacturing, austenitization is followed by a quench; different types of microstructures are formed during this step. Characterizing the impact of Mo and Mn and of cooling rate on these microstructures can help understand how mechanical properties will evolve during tempering and ageing. The impact of molybdenum and manganese, as well as the impact of the cooling rate, were studied on microstructures of three model alloys: FeCMo, FeCMn and FeCMoMn. This was done using continuous cooling transformation (CCT) diagrams and electron backscattering diffraction (EBSD) characterizations. FeCMoMn was found to be a good model for 16 to 20MND5 steels, based on its CCT diagram and hardness. The presence of molybdenum or manganese did not modify the misorientation angle/axis pairs of martensite. In bainitic microstructures however, the presence of Mn seemed to favor the presence of block boundaries with a misorientation about 59° [433]. On the prior austenitic grain (PAG) level, the impact of the cooling rate was rather continuous, from martensite to slowly cooled bainite, and the same regardless of the composition, with the presence of block and sub-block boundaries. The microstructure became coarser with decreasing cooling rate, with fewer crystallographic orientations per PAG.
Sich selbst und andere schätzen
Authors: Brand-Hörsting Birgit
Published: September 2022

Wie verständigen Sie sich mit Ihrem inneren Kritiker, wie mit dem inneren
Entscheider und wodurch unterscheiden sich eigentlich Wertschätzung und
Anerkennung? Hier finden Sie die Antworten – mit vielen praktischen
Beispielen.
„Shifting the Curve“: Neue Entwicklungen und Herausforderungen im Bereich der Public Mental Health
Authors: Reininghaus Ulrich , Schomerus Georg , Hölling Heike , Seidler Andreas , Gerhardus Ansgar , Gusy Burkhard , Riedel-Heller Steffi
Published: September 2022

In der nationalen und internationalen Forschung nimmt das noch relativ junge Fach der Public Mental Health einen immer wichtigeren Stellenwert ein. Allerdings bleibt eine zentrale Herausforderung, dieses Fach in seiner Interdisziplinarität abzubilden und den Diskurs im Spannungsfeld von Public Health, psychiatrischer Epidemiologie, psychischer Gesundheitsförderung, Prävention und Versorgungsforschung zu führen, um sein innovatives Potenzial vollständig auszuschöpfen. In diesem Spannungsfeld stellen sich eine Reihe von grundsätzlichen konzeptionellen und methodischen Fragen, die in diesem Essay unter Bezugnahme auf die Populationsstrategie von Geoffrey Rose exemplarisch auch hinsichtlich fundamentaler Ursachen von sozialen und gesundheitlichen Ungleichheiten erörtert und adressiert werden sollen, mit dem letztendlichen Ziel, die Grundlage zur Erfassung und Veränderung von psychischer Gesundheit auf Populationsebene zu verbessern.
Dokumentation: das Spiegelbild professioneller Therapie
Authors: Heldmann Patrick
Published: September 2022

Ein Blick in die Leitlinien internationaler Verbände oder Organisationen der Physiotherapie gibt Impulse, wie die Dokumentation gestaltet werden könnte. Anhand von Leitfragen werden die einzelnen Empfehlungen und Kriterien vorgestellt – für eine bessere Orientierung im Dokumentationsdschungel.
Teletherapie – Möglichkeiten der Rehabilitation bei Patient*innen nach Knie-Totalendoprothese
Authors: Ayzikov Dmitry
Published: September 2022

Um den Bedarf an Physiotherapie bei der steigenden Zahl an Patient*innen nach einer endoprothetischen Versorgung auch in Zukunft zu decken, benötigen die Gesundheitsdienstleister*innen eine Lösung für die Bereitstellung einer angemessenen Therapie. Eine mögliche Option könnte die Teletherapie sein, die aufgrund der pandemischen Lage von SARS-COV-2 zunehmend an Bedeutung gewinnt. Teletherapie kann Menschen, die aus diversen Gründen nicht in die Praxis kommen können, eine Therapie ermöglichen, und birgt ein kostensparendes Potenzial.

Diese Arbeit sollte klären, ob die physiotherapeutische Teletherapie bei Patient*innen nach einer endprothetischen Versorgung des Knies mit einer konventionellen Physiotherapie vergleichbar ist. Anhand einer Literaturrecherche auf den Datenbanken Cochrane, Europe PMC und PubMed vom 01.01.-04.05.2021 wurden 4 geeignete RCTs gefunden. Alle 4 RCTs zeigten, dass die Teletherapie positive Auswirkungen auf die Funktion der Patient*innen nach einer Knie-Totalendoprothese hat und einer konventionellen Physiotherapie nicht unterlegen ist. Die Ergebnisse waren klinisch signifikant. Die Teletherapie kann demnach als Alternative in Betracht gezogen werden.

Allerdings sind manche Studien auf Grund von methodologischen Schwächen kritisch zu betrachten, sodass diese Arbeit keine eindeutige Empfehlung aussprechen kann. Für ein eindeutiges Ergebnis und eine starke klinische Empfehlung bei Patient*innen nach Knie-Totalendoprothese sind weitere Studien nötig.
Regionale Gesundheitsnetzwerke in Deutschland: Charakteristik und
Finanzierung am Beispiel regionaler Demenznetzwerke
Authors: Michalowsky Bernhard , Afi Adel , Holle Bernhard , Thyrian Jochen René , Hoffmann Wolfgang
Published: September 2022

Ziel der Studie Darstellung der Charakteristik, Finanzierungsstrukturen
und Herausforderungen regionaler Demenznetzwerke sowie der Nutzung der
regionalen finanziellen Netzwerkförderung nach § 45c Abs. 9 SGB
XI.

Methodik Die Analyse basierte auf Daten von 120 Demenznetzwerken, welche
Angaben zur Netzwerkcharakteristik (Verortung, Gründungsjahr, Ziele,
Organisations-, Personal- und Finanzierungsstruktur), den Herausforderungen
sowie der Nutzung der regionalen Netzwerkförderung nach § 45c
Abs. 9 SGB XI machten. Unterschiede in der Organisations-, Personal- und
Finanzierungsstruktur in Abhängigkeit von der Netzwerkcharakteristik
wurden unter der Nutzung von t-Tests und ANOVA analysiert. Die Nutzung der
regionalen Netzwerkförderung nach § 45c Abs. 9 SGB XI wurde
deskriptiv dargestellt und vor dem Hintergrund der geplanten Novellierung
für 2022 diskutiert.

Ergebnisse Der Großteil der Netzwerke etablierte sich zwischen
2011 und 2015, verfolgte Aufklärungs- und Versorgungsziele und vernetzte
im Mittel 28 Akteure. Medizinisch-assoziierte und länger bestehende
Netzwerke sowie Netzwerke mit einer Rechtsform, verfügten über
eine signifikant höhere Anzahl an Netzwerkpartnern und aktiv in die
Netzwerkarbeit eingebundenen Personen sowie Finanzierungsquellen. Die Vernetzung
der Akteure und die Finanzierung wurden als größte
Herausforderungen gesehen. Die regionale Netzwerkförderung nach
§45c Abs. 9 SGB XI war vielen Netzwerken (50%) noch unbekannt.
28% hatten sich bewusst gegen eine Förderung ausgesprochen.
Lediglich jedes zehnte Netzwerk erhielt Fördergelder über den
§45c Abs. 9 SGB XI.

Schlussfolgerung Regionale Demenznetzwerke sind strukturell sehr heterogen
aufgestellt. Die Langlebigkeit, eine medizinische Orientierung sowie eine
bindende Rechtsform können die Anzahl vernetzter Partner sowie
Finanzierungsquellen signifikant beeinflussen und sollten daher
berücksichtigt werden. Bislang konnte nur ein Netzwerk je Landkreis die
maximale Netzwerkförderung nach §45c Abs. 9 (20.000€)
erhalten, was die Nutzbarkeit dieser Förderung, limitiert. Die
gesetztliche Novellierung vergrößert nun die Anzahl an zu
fördernden Netzwerken sowie die Förderhöhe. Es bleibt
abzuwarten, in wie weit diese Anpassungen die Nutzung der regionalen
Netzwerkförderung beeinflusst.
Convenient Synthesis of Ellagic Acid from Methyl Gallate and SARS-CoV-2 3CLpro Antiviral Activity
Authors: Pujol M. Dolors , Navarro Francesc , Hamri Salha , Reches Rosa , Viñas Miquel , Jahani Daniel , Ginard Jaume , Vilardell Josep , Abián Olga
Published: September 2022

A practical synthesis of ellagic acid has been achieved from methyl gallate by a proposed synthetic route of five steps, consisting of ketal protection, regioselective bromination, bis-lactonization, C–C bond formation between the aromatic rings of the galloyl groups, and ketal deprotection, in 38% overall yield. Ellagic acid showed a slight inhibitory activity against SARS-CoV-2 3CLpro.
Asymmetric Synthesis of Derivatives of Alanine via Michael Addition Reaction and their Biological Study
Authors: Mkrtchyan Anna F. , Tovmasyan Anna S. , Paloyan Ani M. , Sargsyan Armen S. , Simonyan Hayarpi M. , Sahakyan Lusine Yu. , Petrosyan Satenik Gh. , Hayriyan Liana A. , Sargsyan Tatev H.
Published: September 2022

Ni(II) complex of the Schiff base of the chiral auxiliary (S)-2-N-(N′-benzylprolyl)aminobenzophenone (BPB) and dehydroalanine as the initial complex in the addition reaction was investigated. The obtained four new derivatives of α-alanine were investigated as inhibitors of aldose reductase. Only one of them: (S)-2-amino-3-[(4-methylbenzyl)amino]propanoic acid showed activity. It becomes a reason for studying the patterns of biological activity of the structure of α-amino acids. The results of docking analysis indicated that (S)-2-amino-3-[(4-methylbenzyl)amino]propanoic acid demonstrated the ability to form bonds with different functional groups of the enzyme which let us assume that some amino acids of nonfunctional groups, such as Trp20 of ALR2, can play a key role in inhibitor–enzyme interactions.
Photo-organocatalytic Synthesis of β-Keto Sulfonyl Fluorides via Radical Fluorosulfonylation of Vinyl Acetates
Authors: Wang Peng , Li Shao-Jie , Liao Saihu , Zhang Honghai , Yang Na
Published: September 2022

A metal-free synthesis of useful β-keto sulfonyl fluorides has been established via radical fluorosulfonylation of ketone-derived vinyl acetates under photoredox organocatalysis by using 1-fluorosulfonyl benzoimidazolium (FABI) as the fluorosulfonyl radical source and oxygen-doped anthanthrene (ODA) as the photocatalyst. A series of aryl and alkyl β-keto sulfonyl fluorides as well as cyclic analogues can be readily obtained in moderate to high yields from widely available ketone starting materials.
Venous Thromboembolism and Risk of Cancer in Users of Low-Dose Aspirin: A Danish Population-Based Cohort Study
Authors: Kurt Gencer , Nagy Dávid , Troelsen Frederikke S. , Skajaa Nils , Erichsen Rune , Farkas Dóra K. , Sørensen Henrik T.
Published: September 2022

Background Aspirin may reduce the risk of cancer, particularly gastrointestinal cancer, and venous thromboembolism (VTE). VTE can be the first symptom of occult cancer, but whether it is also a marker of occult cancer in aspirin users remains unknown. Therefore, we investigated the risk of cancer subsequent to VTE among users of low-dose aspirin.

Methods We conducted a population-based cohort study using data from Danish health registries for the years 2001 to 2018. We identified all patients with a first-time diagnosis of VTE who also redeemed a prescription for low-dose aspirin (75–150mg) within 90 days prior to the first-time VTE. We categorized aspirin users by the number of prescriptions filled as new users (<5 prescriptions), short-term users (5–19 prescriptions), and long-term users (>19 prescriptions). We computed the absolute cancer risks and standardized incidence ratios (SIRs) for cancer using national cancer incidence rates.

Results We followed-up 11,759 users of low-dose aspirin with VTE. Long-term users comprised 50% of aspirin users. The 1-year absolute risk of cancer was 6.0% for new users and 6.7% for short-term and long-term users, with corresponding SIRs of 3.3 (95% confidence interval [CI]: 2.8–4.0), 3.2 (95% CI: 2.9–3.7), and 2.8 (95% CI: 2.6–3.2), respectively. After the first year of follow-up, the SIR decreased to 1.2 (95% CI: 1.1–1.4) for new users, 1.1 (95% CI: 1.1–1.3) for short-term users, and 1.1 (95% CI: 1.0–1.2) for long-term users.

Conclusion VTE may be a harbinger of cancer, even in users of low-dose aspirin, regardless of duration of use.
Behaviorally-Oriented Intensive Aphasia Program: Collaboration Leads to Optimal Outcomes
Authors: Fleming Shawna , Clark Brittany
Published: September 2022

Aphasia is an acquired disorder affecting all language components across modalities. While common therapeutic approaches can result in some improvements, multiple studies establish that intensive therapeutic interventions are most effective; however, these approaches are not well defined. In addition, behaviorally-oriented approaches have been shown to be effective for other conditions, but have not yet been introduced to the treatment of aphasia. The purpose of the current study was to examine the efficacy of a novel, behaviorally-oriented, intensive communication intervention for aphasia (BICA) designed by a speech-language pathologist (second author) and a Board Certified Behavior Analyst (first author) for a 71-year-old woman with post–stroke aphasia. Using a case study design, the participant was provided with 12 hours/week of therapy for 12 weeks focusing on functional communication goals using a behavioral interpretation of language and stimulus control transfer procedures. The behavior analyst determined conceptually systematic interventions based on targets selected by the speech-language pathologist. The participant demonstrated substantial improvements in written language expression and comprehension, reading fluency, oral language expression, naming, and improved quality of life. Given the substantial gains the participant made in oral and written language post-stroke using the BICA therapy, further study is warranted.
Comparison of Outcomes with Triple-Regimen versus Double-Regimen Transarterial Chemoembolization
Authors: Smolock Amanda R. , Deochand Osmani , Rilling William S. , Patel Parag J. , Hohenwalter Eric J. , White Sarah B. , Scheidt Matthew J.
Published: September 2022

We sought to evaluate differences in outcomes between double versus triple transarterial chemoembolization (TACE). TACEs over a 1-year period were retrospectively reviewed and divided into two groups: double and triple. Imaging response and complications were made on a per-procedure basis. Student's t-test was used to calculate differences in continuous variables, and chi-square test was used to calculate differences in categorical values.Overall tumor response was similar between the two groups, and there were no significant differences in complications between groups. Outcomes are similar between double and triple conventional TACE, suggesting that adding a third drug may only contribute to cost.
Chiral resistance effect in an organic helical heterojunction device
Authors: Liu Xuan , Liu Xiaohui , Xie Shijie
Published: September 2022

Chiral-induced spin selectivity has stimulated the investigation of chiral electronics and spintronics. In this theoretical work, we propose chiral resistance (CR) in a heterojunction constituted by two adjacent molecules with different chiralities. We study chirality-dependent transport properties in such a non-magnetic helical heterojunction and find that chiral-induced spin–orbit coupling and chiral-induced spinterface will affect the electron transmission through the device and lead to large CR at low bias. We demonstrate the dependence of CR on the molecule length, the chirality-inversion ratio, and the chirality mismatch. Our studies are helpful to understand the transport properties in a helical heterojunction, and the proposed CR effect could be used to design future spintronics devices.
Sandwich structure endows Na3V2(PO4)3 cathodes with superb sodium storage
Authors: Gao Fengjie , Chen Di , Yang Hui Ying , Yin Yanfeng , Yu Caiyan , Bai Ying
Published: September 2022

Na3V2(PO4)3 (NVP) is a promising cathode for high-energy density sodium-ion batteries, whereas its electrochemical performance is also degraded by its intrinsically inferior electronic conductivity and interfacial side reactions. Herein, Li+, Al3+, and Ti4+ ions were incorporated into the near-surface, and NVP particles were encapsulated by a solid Na+ superionic conductor electrolyte Li1.4Al0.4Ti1.6(PO4)3 (LATP) and carbon (C). Typically, the 0.2 wt. % LATP/C-modified NVP electrode delivers a high initial discharge capacity of 91.22 mA h g−1 and a remarkable rate performance of 56.5 mA h g−1 (20 C). Intensive explorations manifest that the significant improvement in the electrochemical performance of NVP/C could be attributed to the synergistic effects of Li+, Al3+, and Ti4+ doping and the characteristic NVP/LATP/C sandwich coating structure. The modification strategy established in this work synchronously enhanced the electronic conductivity and structural stability of NVP, and this study also provides insight into well-designed electrode microstructures in high-performance batteries.
On-chip fluorescence detection using photonic bandgap guiding optofluidic hollow-core light cage
Authors: Kim Jisoo , Jang Bumjoon , Wieduwilt Torsten , Warren-Smith Stephen C. , Bürger Johannes , Maier Stefan A. , Schmidt Markus A.
Published: September 2022

The on-chip detection of fluorescent light is essential for many bioanalytical and life-science related applications. Here, the optofluidic light cage consisting of a sparse array of micrometer encircling a hollow core represents an innovative concept, particularly for on-chip waveguide-based spectroscopy. In the present work, we demonstrate the potential of the optofluidic light cage concept in the context of integrated on-chip fluorescence spectroscopy. Specifically, we show that fluorescent light from a dye-doped aqueous solution generated in the core of a nanoprinted dual-ring light cage can be efficiently captured and guided to the waveguide ports. Notably, the fluorescence collection occurs predominantly in the fundamental mode, a property that distinguishes it from evanescent field-based waveguide detection schemes that favor collection in higher-order modes. Through exploiting the flexibility of waveguide design and 3D nanoprinting, both excitation and emission have been localized in the high transmission domains of the fundamental core mode. Fast diffusion, detection limits comparable to bulk measurements, and the potential of this approach in terms of device integration were demonstrated. Together with previous results on absorption spectroscopy, the achievements presented here suggest that the optofluidic light cage concept defines a novel photonic platform for integrated on-chip spectroscopic devices and real-time sensors compatible with both the fiber circuitry and microfluidics. Applications in areas such as bioanalytics and environmental sciences are conceivable, while more sophisticated applications such as nanoparticle tracking analysis and integrated Raman spectroscopy could be envisioned.
A wire-shaped and high-sensitivity photoelectrochemical ultraviolet photodetector based on TiO2 nanotube arrays
Authors: Wang Gang , Bai Zhaowen , Wu Hongchang , Zhang Xinmiao , Li Jiang , Jin Mengjing , Zhou Jinyuan , Xie Erqing , Pan Xiaojun
Published: September 2022

The multifunctional and smart ultraviolet photodetectors are of great significance and necessity for applications in many fields, especially in health and environmental risk monitoring. Hence, a wire-shaped photoelectrochemical type ultraviolet photodetector based on photoanode of TiO2 nanotube arrays (TNAs) fabricated by electrochemical anodization is demonstrated in this work. The TNAs can provide direct pathways for carriers and large internal surface area. The assembled UV detector presented a high photocurrent density of 110 μA cm−2, a high ON/OFF ratio of 467, and a fast rise and decay response time of 13 and 19 ms for the optimal thickness of the photoanode of TNAs. Moreover, the detectors also exhibited visible-blind characteristics and an excellent linear response even under weak irradiation (20–100 μW cm−2). The results are beneficial to realizing omnidirectional and wearable optoelectronic devices.
Geometric and doping effects on radiative recombination in thin-film near-field energy converters
Authors: Feng Dudong , Yee Shannon K. , Zhang Zhuomin M.
Published: September 2022

Modeling radiative recombination is crucial to the analysis of radiative energy converters. In this work, a local radiative recombination coefficient is defined and derived based on fluctuational electrodynamics that is applicable to thin-film cells in both the near field and far field. The predicted radiative recombination coefficient of an InAs cell deviates from the van Roosbroeck–Shockley relation when the thickness is less than 10 µm, and the difference exceeds fourfold with a 10 nm film. The local radiative recombination coefficient is orders of magnitude higher when an InAs cell is configured in the near field. The local radiative recombination coefficient reduces as the doping level approaches that of a degenerate semiconductor. The maximum output power and efficiency of a thermoradiative cell would be apparently overpredicted if the electroluminescence coefficient defined in this paper were taken as unity for heavily doped semiconductors.
Realization of p-type In1.75Sb0.25Se3 alloys for short-wave infrared photodetectors
Authors: Li Shasha , Yan Yong , Li Jie , Qian Mengdan , Shen Chenhai , Song Xiaohui , Jiang Yurong , Xia Congxin , Li Jingbo
Published: September 2022

The narrow-gap semiconductors (NGSs) with two-dimensional (2D) layered structures provide fundamental advantages, such as low noise and high quantum efficiency, for short-wave infrared (SWIR) optoelectronic devices. However, realizing high-performance photodetectors based on 2D NGSs with high photoresponsivity, low noise, and fast response speed remains a challenge. Here, we present the design, preparation, and characterization of an In2(1−x)Sb2xSe3 SWIR photodetector. Trivalent antimony (Sb3+) substitutional doping not only induced the β′-β phase transition at room temperature but also made the alloy a good candidate for the p-type semiconductor. Moreover, the individual In1.75Sb0.25Se3 nanoflake realized an excellent photoresponse in a broadband range from visible (405 nm) to SWIR (1550 nm) light with a photoresponsivity of 134 A W−1 and a detectivity of 1.82 × 107 Jones. These performances were superior to the reported In2Se3, Sb2Se3, and other In or Sb selenide photodetectors, which indicated that the β-In2(1−x)Sb2xSe3 alloy may provide a potential building block for short-wave infrared photodetectors.
Active chiral molecules in activity gradients
Authors: Muzzeddu Pietro Luigi , Vuijk Hidde Derk , Löwen Hartmut , Sommer Jens-Uwe , Sharma Abhinav
Published: September 2022

While the behavior of active colloidal molecules is well studied now for constant activity, the effect of activity gradients is much less understood. Here, we explore one of the simplest molecules in activity gradients, namely active chiral dimers composed of two particles with opposite active torques of the same magnitude. We show analytically that with increasing torque, the dimer switches its behavior from antichemotactic to chemotactic. The origin of the emergent chemotaxis is the cooperative exploration of an activity gradient by the two particles. While one of the particles moves into higher activity regions, the other moves towards lower activity regions, resulting in a net bias in the direction of higher activity. We do a comparative study of chiral active particles with charged Brownian particles under a magnetic field and show that despite the fundamental similarity in terms of their odd-diffusive behavior, their dynamics and chemotactic behavior are generally not equivalent. We demonstrate this explicitly in a dimer composed of oppositely charged active particles, which remains antichemotactic to any magnetic field.
Fano plasmonics goes nonlinear
Authors: Sukharev Maxim , Drobnyh Elena , Pachter Ruth
Published: September 2022

We investigate the process of the second harmonic generation by plasmonic nano-antennas that exhibit Fano-like resonances. A rigorous fully vectorial Maxwell-hydrodynamics approach is employed to directly calculate the second order susceptibilities as a function of the pump frequency, considering a periodic array of nanodolmens comprised of three Au nanorods. The results of the numerical simulations demonstrate a noticeable enhancement of the second harmonic efficiency by the antisymmetric mode. Additionally, a simple analytical model based on two coupled nonlinear oscillators is proposed. It is shown that the second order optical response can be significantly enhanced at the frequency of the antisymmetric normal mode, thus supporting our numerical results.
Hybridization and deconfinement in colloidal quantum dot molecules
Authors: Verbitsky Lior , Jasrasaria Dipti , Banin Uri , Rabani Eran
Published: September 2022

The structural, electronic, and optical properties of CdSe/CdS core–shell colloidal quantum dot molecules, a new class of coupled quantum dot dimers, are explored using atomistic approaches. Unlike the case of dimers grown by molecular beam epitaxy, simulated strain profile maps of free-standing colloidal dimers show negligible additional strain resulting from the attachment. The electronic properties of the relaxed dimers are described within a semiempirical pseudopotential model combined with the Bethe–Salpeter equation within the static screening approximation to account for electron–hole correlations. The interplay of strain, hybridization (tunneling splitting), quantum confinement, and electron–hole binding energies on the optical properties is analyzed and discussed. The effects of the dimensions of the neck connecting the two quantum dot building blocks, as well as the shell thickness, are studied.
Wavier jet streams driven by zonally asymmetric surface thermal forcing
Authors: Moon Woosok , Kim Baek-Min , Yang Gun-Hwan , Wettlaufer John S.
Published: September 2022

Recent studies have argued that global warming is responsible for a wavier jet stream, thereby driving midlatitude extreme flooding and drought. Polar amplification—the relative enhancement of high-latitude temperatures under global warming—is argued to be the principal climate state driving midlatitude extremes. Namely, the decreased meridional temperature gradient suppresses the mean zonal winds, leading to wavier midlatitude jets. However, although observations are consistent with such a linkage, a detailed dynamical mechanism is still debated. Here, we argue that the Northern Hemisphere land–sea thermal forcing contrast that underlies zonally asymmetric forcing drives a response in the planetary geostrophic motion, which provides balanced mean fields for synoptic eddies in midlatitudes and thus for wavier jet streams. We show that when the barotropic zonal mean wind
U
is smaller than a threshold, proportional to the
β
-plane effect and dry static stability, the flow field exhibits a dramatic transition from a response confined near the surface to one reaching the upper atmosphere. As global warming enhances polar amplification, the midlatitude jet stream intensity is suppressed. The confluence of these effects leads to wavier jet streams.
Cooperative learning for multiview analysis
Authors: Ding Daisy Yi , Li Shuangning , Narasimhan Balasubramanian , Tibshirani Robert
Published: September 2022

We propose a method for supervised learning with multiple sets of features (“views”). The multiview problem is especially important in biology and medicine, where “-omics” data, such as genomics, proteomics, and radiomics, are measured on a common set of samples. “Cooperative learning” combines the usual squared-error loss of predictions with an “agreement” penalty to encourage the predictions from different data views to agree. By varying the weight of the agreement penalty, we get a continuum of solutions that include the well-known early and late fusion approaches. Cooperative learning chooses the degree of agreement (or fusion) in an adaptive manner, using a validation set or cross-validation to estimate test set prediction error. One version of our fitting procedure is modular, where one can choose different fitting mechanisms (e.g., lasso, random forests, boosting, or neural networks) appropriate for different data views. In the setting of cooperative regularized linear regression, the method combines the lasso penalty with the agreement penalty, yielding feature sparsity. The method can be especially powerful when the different data views share some underlying relationship in their signals that can be exploited to boost the signals. We show that cooperative learning achieves higher predictive accuracy on simulated data and real multiomics examples of labor-onset prediction. By leveraging aligned signals and allowing flexible fitting mechanisms for different modalities, cooperative learning offers a powerful approach to multiomics data fusion.
Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion
Authors: Gamage Dilani G. , Melikov Kamran , Munoz-Tello Paola , Wherley Tanner J. , Focke Leah C. , Leikina Evgenia , Huffman Elliana , Diao Jiajie , Kojetin Douglas J. , Prasad Vikram , Chernomordik Leonid V. , Millay Douglas P.
Published: September 2022

Muscle cell fusion is a multistep process where the final step of the reaction drives progression beyond early hemifusion events to complete fusion. This step requires activity of the muscle-specific fusogen Myomerger, a single-pass transmembrane protein containing 84 amino acids with an ectodomain that includes two α-helices. Previous studies have demonstrated that Myomerger acts by destabilizing membranes through generation of elastic stresses in the outer leaflet of the plasma membrane. An obvious question is how such destabilizing activity might be regulated to avoid membrane and cellular damage, and how the two juxtaposed helices cooperate in fusion. Using cellular fusion assays and in vitro liposome assays, we report that the two helices possess unique characteristics, both of which are needed for full activity of the protein. We demonstrate that externalized phosphatidylserine (PS), a lipid previously implicated in myoblast fusion, has a determinant role in the regulation of Myomerger activity. The membrane-proximal, amphipathic Helix-1 is normally disordered and its α-helical structure is induced by PS, making membrane interactions more efficacious. The distal, more hydrophobic Helix-2 is intrinsically ordered, possesses an ability to insert into membranes, and augments the membrane-stressing effects of Helix-1. These data reveal that Myomerger fusogenic activity is an exquisitely orchestrated event involving its two ectodomain helices, which are controlled by membrane lipid composition, providing an explanation as to how its membrane-stressing activity is spatially and temporally regulated during the final step of myoblast fusion.
Aggregate fluctuations in adaptive production networks
Authors: König Michael D. , Levchenko Andrei , Rogers Tim , Zilibotti Fabrizio
Published: September 2022

To counteract the adverse effects of shocks, such as the global pandemic, on the economy, governments have discussed policies to improve the resilience of supply chains by reducing dependence on foreign suppliers. In this paper, we develop and quantify an adaptive production network model to study network resilience and the consequences of reshoring of supply chains. In our model, firms exit due to exogenous shocks or the propagation of shocks through the network, while firms can replace suppliers they have lost due to exit subject to switching costs and search frictions. Applying our model to a large international firm-level production network dataset, we find that restricting buyer–supplier links via reshoring policies reduces output and increases volatility and that volatility can be amplified through network adaptivity.