bluuebunny/crossref_metadata_2025 huggingface dataset:
The diagnosis and prevalence of hypoprolactinemia in patients with panhypopituitarism and the effects on depression and sexual functions
Authors: Uzun Ilknur , Karaca Zuleyha , Hacioğlu Aysa , Unluhizarci Kursad , Kelestimur Fahrettin
Published: May 2024

Purpose

We aimed to investigate the prevalence and the diagnostic criteria of hypoprolactinemia in patients with panhypopituitarism and the effects of hypoprolactinemia on depression and sexual functions.

Materials and methods

Forty-eight patients with panhypopituitarism and 20 healthy volunteers were included. Basal hormone levels were measured and a TRH stimulation test was performed. For the evaluation of sexual functions, questionnaries of Female Sexual Functional Index (FSFI) for females and International Erectile Functional Index for males were performed to the subjects. Depressive symptoms were evaluated by Beck Depression Envontory score (BDI-II).

Results

The peak PRL response to TRH stimulation test at 5th percentile in the control group was 18.6 ng/ml in males and 41.6 ng/ml in females and accepted as the cut-offs for sufficient response of PRL. Prolactin was insufficient in 42(87.5%) patients. A basal PRL level of ≤ 5.7 ng/ml in males and 7.11 ng/ml in females was 100% specific in predicting an inadequate response to TRH stimulation test with 80% and 70% sensitivity respectively. A basal PRL level of ≥ 8.5 ng/dl in males was 100% specific and 76% sensitive, and in females a level of ≥ 15.2 ng/dl was 96% specific and 66% sensitive in predicting an adequate response to TRH. PRL deficient patients with panhypopituitarism had higher depression scores compared to the controls, lower sexual function scores in males.

Conclusion

PRL deficiency is prevalent among individuals with panhypopituitarism, with the potential to result in elevated depression scores in both sexes and impaired sexual functions in males. A basal PRL level seems to be sufficient for the diagnosis of hypoprolactinemia in routine clinical practice.
Cycle integrals of meromorphic modular forms and Siegel theta functions
Authors: Schwagenscheidt Markus
Published: May 2024

We study meromorphic modular forms associated with positive definite binary quadratic forms and their cycle integrals along closed geodesics in the modular curve. We show that suitable linear combinations of these meromorphic modular forms have rational cycle integrals. Along the way we evaluate the cycle integrals of the Siegel theta function associated with an even lattice of signature (1, 2) in terms of Hecke’s indefinite theta functions.
LCT-Based Framework for the Assessment of Sustainability: From the Perspective of Literature Review
Authors: Khan Kamran , Henschel Thomas
Published: May 2024

In the context of sustainable development, urban transformation should encourage the use of life cycle thinking tools for infrastructure development. By adopting sustainable economic, social, and environmental criteria, this study presents a review of sustainability assessment tools to build a framework for urban infrastructure. It incorporates a variety of methods that economists and industrial ecologists use for evaluating their projects, in addition to the LCT approach. To recognize the strategic sustainability indicators and criteria, the framework uses LCC, LCA, and SLCA in conjunction with stakeholder evaluation and multi-criteria decision analysis, which recognizes the foremost three pillars of sustainability, i.e., economy, environment, and society. Additionally, system dynamics and agent-based modelling are used to optimise the framework. The prominence of the framework is to understand the route an urban infrastructure development should follow to achieve key sustainability interests involving the interconnected environmental and socio-economic aspects. This sustainability assessment framework can be utilised by consultants or supporting agencies to help organisations carry out and monitor such projects.
Not that many leech species after all: Myzobdella lugubris and Myzobdella patzcuarensis (Annelida: Hirudinida) are the same species
Authors: Torres-Carrera Gerardo , Velázquez-Urrieta Yanet , Santacruz Ana
Published: May 2024

The genus Myzobdella groups five species of leeches parasites of fishes mainly of freshwater but with tolerance to brackish waters. Native distribution of these species includes the New World from North to South America. Myzobdella lugubris Leidy, 1851, the type species of the genus, was briefly described based on specimens from the USA, but subsequently their morphology, known distribution and host range were expanded; however, less is known about the other four species of the genus. As part of a survey focusing on characterizing the diversity of leeches from Mexico, specimens of Myzobdella patzcuarensis (Caballero, 1940), from the type locality of the species were included for the first time in a phylogenetic study. In addition, specimens assigned to Myzobdella from the southeast of Mexico as well as from Nicaragua, were also included. In the resulting phylogenetic tree, our newly generated sequences were found nested in the same clade that M. lugubris; with unresolved relationships and relatively low genetic divergence, suggesting conspecificity. In addition, the internal morphology of the specimens of Myzobdella from Mexico is consistent with the description of M. lugubris. Our morphological examination reveals high degrees of variability in the external pigmentation of the specimens. Based on our results we formally synonymize M. patzcuarensis under M. lugubris.
Virtuous Collective Attention
Authors: Kaeslin Isabel
Published: May 2024

How can a collective pay attention virtuously? Imagine a group of scientists. It matters what topics they pay attention to, that is, which topics they draw to the foreground and take to be relevant, and which they leave in the background. It also matters which aspects of an investigated phenomenon they foreground, and which aspects they leave unnoticed in the background. If we want to understand not only how individuals pay attention of this kind virtuously, but also collectives, we first need a framework to understand virtuous collective agency. A result of this article will be that virtuous collective action depends on the collective being institutionalized. At the same time, we have to think of the constituents of the collective in terms of practical identities (as opposed to individuals). This is what enables us to understand how a collective can acquire the stability required for virtue, and how we don’t end up with a summative account of group virtue, respectively. It will be argued that collectives only have the required stability in their actions when their commitments are habitualized in the form of institutionalized procedures. An Aristotelian understanding of virtue distinguishes between commitment, inclination, and action. Only when a subject’s inclination is fully lined up with her commitment, do we arrive at the required stability (of character) for virtuous action. In the case of individuals, to build up an appropriate inclination consists in an inscribing of the commitment into the feelings and body of the subject. If a commitment is fully ‘embodied’ in this sense, it has formed the individual’s inclination accordingly. How can one make sense of this in the case of collective subjects? This article tries to show that for collectives, the embodiment of commitment (the forming of the fitting inclinations) consists in creating policies, procedures, and rules that stabilize the acting according to the commitment, irrespective of the motivation of each individual involved in the collective. Hence, embodiment of commitment, in the case of collectives, is institutionalization. The article then explores what this requirement of institutionalization means for collective attention. The illustration will draw on a distinction between focused and open-minded attention. It will be shown that for either case – focused and open-minded – in order for a collective to pay attention virtuously, it needs to have its commitments institutionalized.
PSMA-positive prostatic volume prediction with deep learning based on T2-weighted MRI
Authors: Laudicella Riccardo , Comelli Albert , Schwyzer Moritz , Stefano Alessandro , Konukoglu Ender , Messerli Michael , Baldari Sergio , Eberli Daniel , Burger Irene A.
Published: May 2024

Purpose

High PSMA expression might be correlated with structural characteristics such as growth patterns on histopathology, not recognized by the human eye on MRI images. Deep structural image analysis might be able to detect such differences and therefore predict if a lesion would be PSMA positive. Therefore, we aimed to train a neural network based on PSMA PET/MRI scans to predict increased prostatic PSMA uptake based on the axial T2-weighted sequence alone.

Material and methods

All patients undergoing simultaneous PSMA PET/MRI for PCa staging or biopsy guidance between April 2016 and December 2020 at our institution were selected. To increase the specificity of our model, the prostatic beds on PSMA PET scans were dichotomized in positive and negative regions using an SUV threshold greater than 4 to generate a PSMA PET map. Then, a C-ENet was trained on the T2 images of the training cohort to generate a predictive prostatic PSMA PET map.

Results

One hundred and fifty-four PSMA PET/MRI scans were available (133 [68Ga]Ga-PSMA-11 and 21 [18F]PSMA-1007). Significant cancer was present in 127 of them. The whole dataset was divided into a training cohort (n = 124) and a test cohort (n = 30). The C-ENet was able to predict the PSMA PET map with a dice similarity coefficient of 69.5 ± 15.6%.

Conclusion

Increased prostatic PSMA uptake on PET might be estimated based on T2 MRI alone. Further investigation with larger cohorts and external validation is needed to assess whether PSMA uptake can be predicted accurately enough to help in the interpretation of mpMRI.
Cooperation in combinatorial search
Authors: Gerbner Dániel , Keszegh Balázs , Nagy Kartal , Patkós Balázs , Wiener Gábor
Published: May 2024

In the game theoretical approach of the basic problem in Combinatorial Search an adversary thinks of a defective element d of an n-element pool X, and the questioner needs to find x by asking questions of type is

$$d\in Q?$$

d
∈
Q
?

for certain subsets Q of X. We study cooperative versions of this problem, where there are multiple questioners, but not all of them learn the answer to the queries. We consider various models that differ in how it is decided who gets to ask the next query, who obtains the answer to the query, and who needs to know the defective element by the end of the process.
The impact of loneliness on depression during the COVID-19 pandemic in China: a two-wave follow-up study
Authors: Yan Linlin , Ding Xu , Gan Yiqun , Wang Naiyi , Wu Jianhui , Duan Hongxia
Published: May 2024

During the COVID-19 pandemic, many regions and countries implemented lockdowns and isolation to curb the virus’s spread, which might increase loneliness and lead to a series of psychological distress. This study aims to investigate the association between loneliness and depression during the COVID-19 pandemic and examine whether perceived social support and perceived internal control mediate the loneliness-depression relationship in China. Self-report questionnaires were distributed online in two waves during the pandemic in 2020. At Wave 1, demographics and loneliness were reported when the lockdown was initially implemented in China, and at Wave 2, as the pandemic came under control and the epicenter lifted its lockdown. Depression, perceived social support, and perceived internal control were measured at both two waves. Higher levels of loneliness at Wave 1 were associated with more depression at Wave 2 after controlling for baseline depression and demographic variables. Simple mediation models showed that both perceived social support and internal control at two waves independently mediated the relationship between Wave 1 loneliness and Wave 2 depression. Additionally, the serial multiple mediation model indicated that perceived social support and perceived internal control sequentially mediated the path from loneliness to subsequent depression. A higher level of loneliness during the initial lockdown was linked with more severe depression with the development of the COVID-19 pandemic. Both perceived social support and perceived internal control acted as essential protective factors against depression from loneliness. Meanwhile, social support might protect mental health by enhancing the sense of self-control when facing loneliness.
Climate adaptation law: a European perspective
Authors: Albrecht Juliane
Published: May 2024

In contrast to climate protection law, which regulates the mitigation of climate change, climate adaptation law deals with the management of the unavoidable consequences of climate change. This article provides an overview of its legal basis from a European perspective. In addition to international law, especially the Paris Agreement, EU law is of central importance in this respect. It is primarily shaped by the EU Climate Law enacted in 2021. However, this Law only sets a general framework and is further defined by legal acts of various sectoral policies, especially in the field of environment. Climate adaptation regulations at the level of European member states are presented using the example of Germany, where a Federal Climate Adaptation Act is currently being drafted. Due to Germany's federal state structure, state legislation is also analysed. Most of the German states (“Länder”) have their own climate laws, although their content varies. The municipal level is only addressed with restraint in these laws. The reasons for this are of a fiscal constitutional nature and will be explained in more detail.
Improving the in-situ upgrading of extra heavy oil using metal-based oil-soluble catalysts through oxidation process for enhanced oil recovery
Authors: Nejad Zare Reza , Mehrabi-Kalajahi Seyedsaeed , Varfolomeev Mikhail A. , Talipov Sarvar , Zinnatullin Almaz L. , Sadikov Kamil G. , Vagizov Farit G.
Published: May 2024

The demand for fuel from unconventional sources is increasing all over the world, however, there are still special and strict regulations regarding the methods of enhanced oil recovery as well as the content of the oil produced, including the amount of sulfur. In-situ combustion (ISC) is an attractive thermal method to enhance oil recovery and in-situ upgrading process. In this work, copper (II) oleate and copper (II) stearate were used for the oxidation of extra heavy oil with high sulfur content in the ISC process using a self-designed porous medium thermo-effect cell (PMTEC) and visual combustion tube. Using PMTEC the catalytic performances of the synthesized oil-soluble copper (II) oleate and copper (II) stearate and kinetic parameters such as activation energy using Ozawa-Flynn-Wall method were studied. The X-ray diffraction (XRD) and high-resolution field emission scanning electron microscopy were used to examine the characteristics of in-situ synthesized CuO nanoparticles during oxidation. As shown, the presence of oil-soluble copper (II) stearate and copper (II) oleate reduced oil viscosity from 9964 to 8000 and 6090 mPa˙s, respectively. Following ISC process in porous media in the presence of copper (II) oleate, the high sulfur extra heavy oil upgraded, and its sulfur content decreased from 10.33 to 6.79%. Additionally, SARA analysis revealed that asphaltene and resin content decreased in the presence of oil-soluble catalysts. During the oxidation reaction, homogeneous catalyst decomposed into nanoparticles, and heterogeneous catalyst is distributed uniformly in porous media and played an active role in the catalytic process. It should be noticed that, these kind of oil-soluble catalysts can be novel and highly potential candidates for initiation and oxidation of extra heavy oil in order to decrease the viscosity, enhanced oil recovery and production of the upgraded oil.

Graphical abstract
A case–control study of the clinical and economic impact of infections caused by Carbapenemase-producing Enterobacterales (CPE)
Authors: López Montesinos Inmaculada , Carot-Coll Aina , Montero Maria Milagro , Sorli Redó Luisa , Siverio-Parès Ana , Esteban-Cucó Sandra , Durán Xavier , Gomez-Zorrilla Silvia , Horcajada Juan Pablo
Published: May 2024

Purpose

The aim was to analyse the clinical and economic impact of carbapenemase-producing Enterobacterales (CPE) infections.

Methods

Case–control study. Adult patients with CPE infections were considered cases, while those with non-CPE infections were controls. Matching criteria were age (± 5 years), sex, source of infection and microorganism (ratio 1:2). Primary outcome was 30-day mortality. Secondary outcomes were 90-day mortality, clinical failure, hospitalisation costs and resource consumption.

Results

246 patients (82 cases and 164 controls) were included. Klebsiella pneumoniae OXA-48 was the most common microorganism causing CPE infections. CPE cases had more prior comorbidities (p = 0.007), septic shock (p = 0.003), and were more likely to receive inappropriate empirical and definitive antibiotic treatment (both p < 0.001). Multivariate analysis identified septic shock and inappropriate empirical treatment as independent predictors for 7-day and end-of-treatment clinical failure, whereas Charlson Index and septic shock were associated with 30- and 90-day mortality. CPE infection was independently associated with early clinical failure (OR 2.18, 95% CI, 1.03–4.59), but not with end-of-treatment clinical failure or 30- or 90-day mortality. In terms of resource consumption, hospitalisation costs for CPE were double those of the non-CPE group. CPE cases had longer hospital stay (p < 0.001), required more long-term care facilities (p < 0.001) and outpatient parenteral antibiotic therapy (p = 0.007).

Conclusions

The CPE group was associated with worse clinical outcomes, but this was mainly due to a higher comorbidity burden, more severe illness, and more frequent inappropriate antibiotic treatment rather than resistance patterns as such. However, the CPE group consumed more healthcare resources and incurred higher costs.
Militant Rule of Law and Not-so-Bad Law
Authors: Sajó András
Published: May 2024

The article provides intellectual arguments and tools from legal dogmatics that can help to counter the rule of law backlash. It argues that resilience can be boosted by a systemic militant rule of law approach. When it comes to restoring the rule of law, legal theory turns to the Radbruch formula (supra-statutory law). This approach remains contested by lawyers who are convinced – following the tradition of positivist legal theory – that invoking this formula is unacceptable because it violates a fundamental requirement of the rule of law, namely that of legality. Irrespective of the value of this concern, Radbruch’s formula is not applicable to the current demise of the rule of law, as the law resulting from cheating and abuse in illiberal regimes does not result in evil law (though it may facilitate such developments). Instead of evil law, we face not-so-bad law. Legal imperfections exist in every legal system, and militant rule of law necessitates the systemic revision of these shortcomings in order to preempt the abuses of an anti-formalistic populist regime. In illiberal regimes, the self-corrective mechanisms of the rule of law are gradually eliminated, but the name of the game remains the rule of law. It means that judges still have (some) power to counter the backlash using extant interpretive techniques (for a while). This article will begin by introducing the concept of not-so-bad (NSB) law as an imperfection of the rule of law. In Part Two, the validity of NSB laws is discussed by relying on the source theory. It argues that even if validity is a matter of conformity to the source, the source can be understood to contain a legal merit component as determined by the rule of law, and falling short on this legal merit component can constitute a ground for declaring the norm’s invalid. Part Three describes the abuses of the rule of law in illiberal democracies and describes how the NSB law of illiberal regimes does not satisfy the validity requirements of legal positivism. Part Four discusses the opportunities open to judges for resisting or undoing NSB law using existing techniques of legal interpretation and without violating rule of law principles.
Intellectual History and the Problem of Conceptual Change
Authors: Palti Elías J.
Published: May 2024

How does long-term intellectual change occur? Can we develop a theoretical framework for understanding past systems of knowledge? In this ambitious study, Elías José Palti seeks to reassess the main concepts in the field of intellectual history. Evaluating modes of thought from the seventeenth century to the present, this book aims to prevent an anachronistic understanding of the texts of the past. Palti rejects the idea of conceptual change as a coherent process deriving from one single source. Instead, he offers a convincing explanation of converging developments emanating from three different sources: namely, the Cambridge school, the German school of conceptual history, or Begriffsgeschichte, and French politico-conceptual history. Intellectual History and the Problem of Conceptual Change also closely examines the temporality of concepts, questioning how and why political languages mutate.
Bad Religion and Bad Business: The History of the Canadian Witchcraft Provision
Authors: Klassen-Molyneaux Riley
Published: May 2024

Witchcraft is a fascinating subject on which many volumes continue to be published. But not in Canada. This article stands in contrast to earlier Canadian pieces on witchcraft whose primary goals were to prove that the witchcraft provision marginalized women and to encourage legislators to repeal it. Parliament finally repealed the Canadian witchcraft prohibition in 2018. The moment is thus ripe to ask how—and why—this legislative oddity migrated from England into Canada. The first section of the paper considers the religious origins of the witchcraft prohibition in England and how it made its way into the Canadian Criminal Code. The second section explores how the prohibition evolved from one against unwanted spiritual practices to one against unwanted economic practices. The last section of the paper considers how witchcraft morphed into a viable Charter defence based on freedom of religion and why the prohibition against it was eventually repealed. In conclusion, the article reflects on the peculiar trajectory of witchcraft in Canada and what it might suggest not only about Canadian criminal law, but also about broader Canadian society.
The Feminine Force in Early Daoist Thought
Authors: Small Sharon Y.
Published: May 2024

According to theLaozione of the ways to cultivate and grasp Dao is through “remaining female” and “nourishing the mother.” The term mother is used in reference to the beginning of all existence—“the mother of all under heaven,” “the mother of all existences.” The mother is both an active force of generation and the concreteness of the generated beings. In this sense, the feminine attribute of motherhood is a living embodiment of Dao. In the world of myriad phenomena, the mother provides a location of interaction between “absence” and “presence,” betweenwuandyou. In this paper, I suggest an analysis of the metaphor of mother and other “feminine roles” in early Daoist thought through a textual examination of the Laozi. Considering the intellectual background in Warring States period China in which the common understanding of the universe and all phenomena is revealed through the interactions of correlative and complementary forces, the esteem of one over the other—the feminine over the male, the mother over father—is outstanding and deserves serious investigation. The question is what can we learn from the feminine, what can femininity teach us about the world, its generation, and even political practice?
A remark on exact simulation of tempered stable Ornstein–Uhlenbeck processes
Authors: Arai Takuji , Imai Yuto
Published: May 2024

Qu, Dassios, and Zhao (2021) suggested an exact simulation method for tempered stable Ornstein–Uhlenbeck processes, but their algorithms contain some errors. This short note aims to correct their algorithms and conduct some numerical experiments.
Reflections on punctuated equilibria
Authors: Eldredge Niles
Published: May 2024

It is a pleasure to be invited to contribute to the celebration of the publication of “punctuated equilibria” (“punk eek”) 50 years ago—the canonical version I did with Steve Gould (Eldredge and Gould 1972) at the behest of Tom Schopf for his visionary project to inject more thought, more interpretation and theory, into the working lives of paleontologists.
The Translational Turn and the Dual Pressures on Chinese Literary Studies
Authors: Klein Lucas
Published: May 2024

Whereas sinology, or the study of Chinese literature in English, has often been identifiable by a Chinese culturism, or belief in Chinese civilization as a coherent whole united by its writing system, this review article looks at five books that could be described as participating in a “translational turn” in Chinese literary studies. Yet even as they make powerful arguments against the fundamental unity and cohesiveness of a diachronic Chinese cultural-political identity in their translingual and translational approaches to scholarship, the books—Carla Nappi’s Translating Early Modern China (2021), Haun Saussy’s The Making of Barbarians (2022), Tze-Yin Teo’s If Babel Had A Form (2022), Yunte Huang’s Chinese Whispers (2022), and Nan Z. Da’s Intransitive Encounter (2018)—risk taking for granted the longevity of China’s participation in globalization and its economic integration with the United States. In light of current changes to the relationship between China, the US, and the world order, this review article reads these books while attempting to think through the gains and pitfalls of the translational turn in Chinese literary studies.
Risk of spread of the Asian citrus psyllid Diaphorina citri Kuwayama (Hemiptera: Liviidae) in Ghana
Authors: Ninsin Kodwo Dadzie , Souza Philipe Guilherme Corcino , Amaro George Correa , Aidoo Owusu Fordjour , Barry Edmond Joseph Djibril Victor , da Silva Ricardo Siqueira , Osei-Owusu Jonathan , Dofuor Aboagye Kwarteng , Ablormeti Fred Kormla , Heve William K. , Edusei George , Agboyi Lakpo Koku , Beseh Patrick , Boafo Hettie Arwoh , Borgemeister Christian , Sétamou Mamoudou
Published: May 2024

The impact of invasive species on biodiversity, food security and economy is increasingly noticeable in various regions of the globe as a consequence of climate change. Yet, there is limited research on how climate change affects the distribution of the invasive Asian citrus psyllid Diaphorina citri Kuwayama (Hemiptera:Liviidae) in Ghana. Using maxnet package to fit the Maxent model in R software, we answered the following questions; (i) what are the main drivers for D. citri distribution, (ii) what are the D. citri-specific habitat requirements and (iii) how well do the risk maps fit with what we know to be correctly based on the available evidence?. We found that temperature seasonality (Bio04), mean temperature of warmest quarter (Bio10), precipitation of driest quarter (Bio17), moderate resolution imaging spectroradiometer land cover and precipitation seasonality (Bio15), were the most important drivers of D. citri distribution. The results follow the known distribution records of the pest with potential expansion of habitat suitability in the future. Because many invasive species, including D. citri, can adapt to the changing climates, our findings can serve as a guide for surveillance, tracking and prevention of D. citri spread in Ghana.
Recent results on high-β plasma confinement studies in the Gas Dynamic Trap
Authors: Shmigelsky Evgeniy A. , Lizunov Andrej A. , Meyster Andrey K. , Pinzhenin Egor I. , Solomakhin Alexander L. , Yakovlev Dmitry V.
Published: May 2024

This paper is devoted to experimental studies of plasma confinement with high relative pressure (

$\beta$

) in the Gas Dynamic Trap (BINP, Novosibirsk). In previous high-

$\beta$

confinement studies a maximum local

$\beta = 0.6$

was achieved in the fast-ion turning point, contributed to by a beam-driven population of fast ions with an anisotropic distribution function. In this study the axial magnetic field profile was modified to bring the turning points closer to one another, which effectively increased the energy density of plasma and pushed the

$\beta$

value higher. Experiments were performed for two non-standard magnetic configurations, where the axial fast-ion confinement region length was reduced by 1.5 and 2 times compared with the standard configuration. The average values of

$\langle \beta _{\perp } \rangle$

over the plasma central cross-section were found to be 0.1 and 0.18, respectively, for the two configurations, with the latter value significantly exceeding the

$\langle \beta _{\perp } \rangle =0.08$

of the standard configuration, in which the previous record was set. Moreover, halving the fast ion confinement region almost doubled the D–D fusion proton flux from the trap centre compared with the standard configuration. The electron temperature in both new magnetic configurations was only slightly smaller than in the standard configuration. In addition, an effect of Alfvén ion–cyclotron instability (AICI) development on the pressure in the turning points is discussed. Presumably, with some decrease in magnetic field an evolving AICI does not result in considerable pressure axial redistribution, so the pressure maximum is in the turning points’ vicinity despite the instability.
Richard Pryor’s Sonic Acts: Epistemological Rupture at the Hollywood Bowl, 18 September 1977
Authors: Russell Eleanor
Published: May 2024

The jokes that stick in people's minds are the ones they don't quite get.
“Put money in thy purse. Follow thou the wars”: Othello, the Mexican–American War, and Manifest Destiny
Authors: Canning Charlotte M.
Published: May 2024

In the winter of 1845–6 the United States Army languished on the border waiting for an opportunity to provoke what would be the Mexican–American War, or, as the Mexicans would come to call it, La Intervención Americana. To break the dull monotony, the army turned to theatre. In January, Second Lieutenant Ulysses S. Grant was cast as Desdemona in a production staged for the troops and the local community. Grant would later be the victorious general in the Civil War and the eighteenth president of the United States from 1869 to 1877. He was not yet that person. In 1846 he was a twenty-four-year-old, newly commissioned officer, only three years out of the US Military Academy. His peers, a cohort of junior officers who would become the senior military leadership on both sides of the Civil War, were also actors in the production, as well as its producers. The anecdote is humorous in large part because the Grant of national record and memory is the least Desdemona-like figure anyone can conceive. It has been repeated multiple times across the nineteenth century and still holds in the imagination almost two hundred years later.
The role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis
Authors: May Andrew K. , Smeeth Demelza , McEwen Fiona , Karam Elie , Rieder Michael J. , Elzagallaai Abdelbaset A. , van Uum Stan , Lionetti Francesca , Pluess Michael
Published: May 2024

Individuals with high environmental sensitivity have nervous systems that are disproportionately receptive to both the protective and imperilling aspects of the environment, suggesting their mental health is strongly context-dependent. However, there have been few consolidated attempts to examine putative markers of sensitivity, across different levels of analysis, within a single cohort of individuals with high-priority mental health needs. Here, we examine psychological (self-report), physiological (hair hormones) and genetic (polygenic scores) markers of sensitivity in a large cohort of 1591 Syrian refugee children across two waves of data. Child-caregiver dyads were recruited from informal tented settlements in Lebanon, and completed a battery of psychological instruments at baseline and follow-up (12 months apart). Univariate and multivariate Bayesian linear mixed models were used to examine a) the interrelationships between markers of sensitivity and b) the ability of sensitivity markers to predict anxiety, depression, post-traumatic stress disorder, and externalising behaviour. Self-reported sensitivity (using the Highly Sensitive Child Scale) significantly predicted a higher burden of all forms of mental illness across both waves, however, there were no significant cross-lagged pathways. Physiological and genetic markers were not stably predictive of self-reported sensitivity, and failed to similarly predict mental health outcomes. The measurement of environmental sensitivity may have significant implications for identifying and treating mental illness, especially amongst vulnerable populations, but clinical utility is currently limited to self-report assessment.
COQ7 defect causes prenatal onset of mitochondrial CoQ10 deficiency with cardiomyopathy and gastrointestinal obstruction
Authors: Pettenuzzo Ilaria , Carli Sara , Sánchez-Cuesta Ana , Isidori Federica , Montanari Francesca , Grippa Mina , Lanzoni Giulia , Ambrosetti Irene , Di Pisa Veronica , Cordelli Duccio Maria , Mondardini Maria Cristina , Pippucci Tommaso , Ragni Luca , Cenacchi Giovanna , Costa Roberta , Lima Mario , Capristo Maria Antonietta , Tropeano Concetta Valentina , Caporali Leonardo , Carelli Valerio , Brunelli Elena , Maffei Monica , Ahmed Sheikhmaye Hodman , Fetta Anna , Brea-Calvo Gloria , Garone Caterina
Published: May 2024

COQ7pathogenetic variants cause primary CoQ10deficiency and a clinical phenotype of encephalopathy, peripheral neuropathy, or multisystemic disorder. Early diagnosis is essential for promptly starting CoQ10supplementation. Here, we report novel compound heterozygous variants in theCOQ7gene responsible for a prenatal onset (20 weeks of gestation) of hypertrophic cardiomyopathy and intestinal dysmotility in a Bangladesh consanguineous family with two affected siblings. The main clinical findings were dysmorphisms, recurrent intestinal occlusions that required ileostomy, left ventricular non-compaction cardiomyopathy, ascending aorta dilation, arterial hypertension, renal dysfunction, diffuse skin desquamation, axial hypotonia, neurodevelopmental delay, and growth retardation. Exome sequencing revealed compound heterozygous rare variants in theCOQ7gene, c.613_617delGCCGGinsCAT (p.Ala205HisfsTer48) and c.403A>G (p.Met135Val). In silico analysis and functional in vitro studies confirmed the pathogenicity of the variants responsible for abolished activities of complexes I + III and II + III in muscle homogenate, severe decrease of CoQ10levels, and reduced basal and maximal respiration in patients’ fibroblasts. The first proband deceased at 14 months of age, whereas supplementation with a high dose of CoQ10(30 mg/kg/day) since the first days of life modified the clinical course in the second child, showing a recovery of milestones acquirement at the last follow-up (18 months of age). Our study expands the clinical spectrum of primary CoQ10deficiency due toCOQ7gene defects and highlights the essential role of multidisciplinary and combined approaches for a timely diagnosis.
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification
Authors: Yang Seungbok , Golkaram Mahdi , Oh Seyoun , Oh Yujeong , Cho Yoonjae , Yoe Jeehyun , Ju Sungeun , Lalli Matthew A. , Park Seung-Yeol , Lee Yoontae , Jang Jiwon
Published: May 2024

Dynamic changes in mechanical microenvironments, such as cell crowding, regulate lineage fates as well as cell proliferation. Although regulatory mechanisms for contact inhibition of proliferation have been extensively studied, it remains unclear how cell crowding induces lineage specification. Here we found that a well-known oncogene, ETS variant transcription factor 4 (ETV4), serves as a molecular transducer that links mechanical microenvironments and gene expression. In a growing epithelium of human embryonic stem cells, cell crowding dynamics is translated into ETV4 expression, serving as a pre-pattern for future lineage fates. A switch-like ETV4 inactivation by cell crowding derepresses the potential for neuroectoderm differentiation in human embryonic stem cell epithelia. Mechanistically, cell crowding inactivates the integrin–actomyosin pathway and blocks the endocytosis of fibroblast growth factor receptors (FGFRs). The disrupted FGFR endocytosis induces a marked decrease in ETV4 protein stability through ERK inactivation. Mathematical modelling demonstrates that the dynamics of cell density in a growing human embryonic stem cell epithelium precisely determines the spatiotemporal ETV4 expression pattern and, consequently, the timing and geometry of lineage development. Our findings suggest that cell crowding dynamics in a stem cell epithelium drives spatiotemporal lineage specification using ETV4 as a key mechanical transducer.
Research on the method of determining the block size for an open-pit mine integrating mining parameters and shovel-truck’s operation efficiency
Authors: Guo Weiqiang , Liu Guangwei , Li Jiaming , Chai Senlin , Guo Shupeng
Published: May 2024

The production plan of an open-pit mine depends on the block model, so it's crucial to determine the appropriate method and size for partitioning it. This study proposes a new method based on a closed shell three-dimensional geological model for determining block model size in open-pit mines. Instead of using regular block models, the shell model is directly cut, and the discrete geological body is referred to as the "mining model." Mining parameters and the shovel-truck's performance are integrated into the method. Bench height determines the Z-axis size, bench slope angle determines the inclination angle, and shovel width determines the X-axis size of the block model. The operation efficiency of the shovel-truck considers the probability distribution of simultaneous operations, allowing the determination of the Y-axis size of block models for different types of shovels. The developed "Mining Model" module in the software "Life Cycle Mining System" is used for practical implementation. By comparing the results with traditional block models, the superiority of the proposed method is demonstrated. This study provides a more accurate model for optimizing the production plan of open-pit mines throughout their life cycle.
Elucidating immunological characteristics of the adenoma-carcinoma sequence in colorectal cancer patients in South Korea using a bioinformatics approach
Authors: Song Jaeseung , Kim Daeun , Jung Junghyun , Choi Eunyoung , Lee Yubin , Jeong Yeonbin , Lee Byungjo , Lee Sora , Shim Yujeong , Won Youngtae , Cho Hyeki , Jang Dong Kee , Kang Hyoun Woo , Joo Jong Wha J. , Jang Wonhee
Published: May 2024

Colorectal cancer (CRC) is one of the top five most common and life-threatening malignancies worldwide. Most CRC develops from advanced colorectal adenoma (ACA), a precancerous stage, through the adenoma-carcinoma sequence. However, its underlying mechanisms, including how the tumor microenvironment changes, remain elusive. Therefore, we conducted an integrative analysis comparing RNA-seq data collected from 40 ACA patients who visited Dongguk University Ilsan Hospital with normal adjacent colons and tumor samples from 18 CRC patients collected from a public database. Differential expression analysis identified 21 and 79 sequentially up- or down-regulated genes across the continuum, respectively. The functional centrality of the continuum genes was assessed through network analysis, identifying 11 up- and 13 down-regulated hub-genes. Subsequently, we validated the prognostic effects of hub-genes using the Kaplan–Meier survival analysis. To estimate the immunological transition of the adenoma-carcinoma sequence, single-cell deconvolution and immune repertoire analyses were conducted. Significant composition changes for innate immunity cells and decreased plasma B-cells with immunoglobulin diversity were observed, along with distinctive immunoglobulin recombination patterns. Taken together, we believe our findings suggest underlying transcriptional and immunological changes during the adenoma-carcinoma sequence, contributing to the further development of pre-diagnostic markers for CRC.
Enhanced microstructure and mechanical properties of ZrN-reinforced AlSi10Mg aluminum matrix composite
Authors: Suvorova Veronika , Volodko Sergey , Suvorov Dmitrii , Chernyshikhin Stanislav , Nepapushev Andrey , Korol Artem , Volkova Lidiya , Sokolov Pavel , Khort Alexander , Moskovskikh Dmitry
Published: May 2024

Aluminum matrix composites (AMCs), incorporating Zirconium Nitride (ZrN) as reinforcing additives, demonstrate immense promise for applications in aerospace, automotive, and power generation due to their unique combination of low density, superior mechanical properties, and excellent thermal/electrical conductivity. This study explores the influence of ZrN reinforcement on the microstructure and mechanical properties of AlSi10Mg metal-matrix composites. Utilizing high-energy ball milling (HEBM) and spark-plasma sintering (SPS), ZrN/AlSi10Mg composites were synthesized, achieving nearly full density with uniform ZrN distribution, while phase and chemical transformations were not observed in the bulk composites. The addition of ZrN resulted in a notable increase in hardness of 237% (182 ± 8 HV2), elastic modulus of 56% (114 ± 3 GPa), compressive and tensile strength of 183% (565 ± 15 GPa), and 125% (387 ± 9 GPa), respectively, for composites containing 30% ZrN, compared to the non-reinforced alloy. Experimentally determined coefficients of thermal expansion (CTEs) for composites with 10%, 20%, and 30% ZrN content were 19.8 × 10−6 °C−1, 19.1 × 10−6 °C−1, and 18 × 10−6 °C−1, respectively, which well relates to Schapery’s model. These findings contribute to understanding the synthesis, mechanical behavior, and thermal properties of ZrN/AlSi10Mg composites, demonstrating their potential for diverse engineering applications.
Unlocking the potential of blockchain technology in enhancing the fisheries supply chain: an exploration of critical adoption barriers in China
Authors: Nisar Ubair , Zhang Zhixin , Wood Bronwyn P. , Ahmad Shadab , Ellahi Ehsan , Ul Haq Syed Ijaz , Alnafissa Mohamad , Fathi Abd-Allah Elsayed
Published: May 2024

The application of blockchain technology holds significant potential for improving efficiency, resilience, and transparency within the Fisheries Supply Chain (FSC). This study addresses the critical barriers hindering the adoption of blockchain technology (BT) in the Chinese FSC, recognizing the unique challenges posed by its intricacies. Through a comprehensive literature review, fourteen Critical Barrier Factors (CBFs) were identified, and a grey Delphi method was employed to distill this set. Five pivotal CBFs emerged, including "Regulatory Compliance," "Cost of Implementation," and "Complex Supply Chain Network". A subsequent grey Decision-Making Trial and Evaluation Laboratory (DEMATEL) analysis revealed the causal relationships among these factors, categorizing them into effect and cause groups. "Regulatory Compliance," "Cost of Implementation," and "Complex Supply Chain Network" were identified as primary influencing factors demanding attention for effective BT integration in the FSC. The findings serve as a valuable resource for FSC stakeholders, assisting in prioritizing efforts to address these barriers. The discerned causal relationships provide guidance for managers in optimizing resource allocation. Ultimately, this research advocates for the adoption of blockchain technology in the fisheries supply chain to enhance overall performance and operational efficiency.
Boosting photocatalytic water splitting of TiO2 using metal (Ru, Co, or Ni) co-catalysts for hydrogen generation
Authors: Thabet Safinaz M. , Abdelhamid Hani Nasser , Ibrahim Said A. , El-Bery Haitham M.
Published: May 2024

The photocatalytic activity of titanium dioxide (TiO2) nanoparticles toward hydrogen generation can be significantly improved via the loading of various metals e.g., Ru, Co, Ni as co-catalysts. The metal co-catalysts are loaded into TiO2 nanoparticles via different deposition methods; incipient wet impregnation (Imp), hydrothermal (HT), or photocatalytic deposition (PCD). Among all of the tested materials, 0.1 wt% Ru–TiO2 (Imp) provided the highest initial hydrogen catalytic rate of 23.9 mmol h−1 g−1, compared to 10.82 and 16.55 mmol h−1 g−1 for 0.3 wt% Ni–TiO2 (Imp) and 0.3 wt% Co–TiO2 (Imp), respectively. The loading procedures, co-catalyst metals type, and their loading play a significant role in elevating the photocatalytic activity of pristine TiO2 semiconductors toward hydrogen generation. Redox transition metals e.g., Co and Ni exhibit comparable photocatalytic performance to expensive elements such as Ru.
Association between low-density lipoprotein cholesterol levels and serum uric acid to serum creatinine ratio in Chinese male gout patients
Authors: Shao Qian , Chi Jingwei , Che Kui , Zhou Yue , Huang Yajing , Wang Yunyang , Xue Yu , Wang Yangang
Published: May 2024

This study aimed to evaluate the association between low-density lipoprotein cholesterol (LDL-C) and serum uric acid to serum creatinine (SUA/SCr) ratio in male gout patients at different BMIs. This real-world study included 956 male gout patients aged 18–83 years. We retrospectively analyzed the medical records of Chinese male gout patients from 2017 to 2019. The correlation between LDL-C and SUA/SCr was tested after adjusting for confounding factors. We found a nonlinear relationship between LDL-C and SUA/SCr in the whole study population. Stratification analysis showed that there was actually a nonlinear relationship between LDL-C and SUA/SCr in men with a BMI of 24–28, the inflection point of LDL-C was 1.8 mmol/L, when LDL-C was greater than 1.8 mmol/L, there was a positive correlation between LDL-C levels and SUA/SCr (β = 0.67, 95% CI 0.35–0.98, P < 0.001). Moreover, LDL-C showed a significant positive correlation with SUA/SCr with a BMI of 28 or greater (β = 0.30, 95% CI 0.05–0.55, P = 0.019). However, no association was found between LDL-C and SUA/SCr with a BMI of less than 24 (β = 0.42, 95% CI − 0.03–0.86, P = 0.070). LDL-C levels were associated with SUA/SCr in Chinese male gout patients, but this correlation appeared inconsistent among different BMIs. Our findings suggest that LDL-C levels may be more noteworthy in overweight and/or obese male gout patients.