bluuebunny/crossref_metadata_2025 huggingface dataset:
Партисипативне прогнозування: адаптація європейського досвіду до завдань повоєнного відновлення україни
Authors: Sushyi Olena
Published: October 2022

Актуальність. У статті порушено проблему повоєнного відновлення України у зрізі соціальної прогностики, зокрема європейського досвіду проведення форсайт-досліджень майбутнього за участі громадян.

Метою статті є огляд теоретичних і методологічних засад партисипативного прогнозування та визначення можливостей його апробації як технології (інструменту) для реалізації цілей повоєнного відновлення в Україні.

Результати. Уточнено понятійно-категоріальний апарат дослідження щодо визначення західних підходів до дослідження майбутнього, критеріїв аналізу практики участі загалом та в дослідженнях майбутнього зокрема, запропоновано визначення поняття «партисипативне прогнозування». Наведено огляд форсайт-проєктів: Civisti (2009–2011), Casi (2014–2017) та Cimulact (2015–2016), які є прикладом проведення спільних досліджень майбутнього та інституціоналізації участі громадян як незалежних áкторів та áвторів візій майбутнього. Названі форсайт-проєкти було реалізовано в Європейському союзі за фінансової підтримки Європейської комісії. За результатами аналізу здійснено початкове узагальнення методологічних засад та уточнено процедуру партисипативного прогнозування, визначено його переваги та недоліки (побічні ефекти). Запропоновано авторські міркування щодо потенціалу партисипативного прогнозування для цілей повоєнного відновлення України. Наголошується, що партисипативне прогнозування може стати ефективною технологією опанування травматичних наслідків та повоєнного відновлення громад в Україні. Окрім своєї безпосередньої мети – прогнозування та планування майбутнього, партисипативне прогнозування дає можливість одночасно проводити системну фахову соціально-психологічну реабілітацію на рівні великих соціальних груп (суспільство, нація) та спільнот (територіальна, конфесійна, етнічна тощо), а також здійснювати м’яке коригування масових (колективних) соціально-психологічних станів. Реалізація партисипативних досліджень майбутнього у формі дискурсійної участі можлива як шляхом «експертного діалогу», спрямованого на міждисциплінарне співробітництво та подолання роздробленості наукового знання; так і шляхом «соціального діалогу», спрямованого на залучення зацікавлених сторін (вони можуть бути прямо чи опосередковано зацікавлені) до громадського обговорення в рамках дорадчого процесу.

Перспективи подальших досліджень. Запровадження практик партисипативного прогнозування потребує координації зусиль з боку урядовців, експертного середовища і громадян, свідомої готовності кожної зі сторін до співпраці та відповідальності за свій внесок у справу спільного майбутнього.
Oral HDAC inhibitor tucidinostat in patients with relapsed or refractory peripheral T-cell lymphoma: phase IIb results
Authors: Rai Shinya , Kim Won Seog , Ando Kiyoshi , Choi Ilseung , Izutsu Koji , Tsukamoto Norifumi , Yokoyama Masahiro , Tsukasaki Kunihiro , Kuroda Junya , Ando Jun , Hidaka Michihiro , Koh Youngil , Shibayama Hirohiko , Uchida Toshiki , Yang Deok Hwan , Ishitsuka Kenji , Ishizawa Kenichi , Kim Jin Seok , Lee Hong Ghi , Minami Hironobu , Eom Hyeon Seok , Kurosawa Mitsutoshi , Lee Jae Hoon , Lee Jong Seok , Lee Won Sik , Nagai Hirokazu , Shindo Takero , Yoon Dok Hyun , Yoshida Shinichiro , Gillings Mireille , Onogi Hiroshi , Tobinai Kensei
Published: October 2022

Tucidinostat (formerly known as chidamide) is an orally available, novel benzamide class of histone deacetylase (HDAC) inhibitor that selectively blocks class I and class IIb HDAC. This multicenter phase IIb study aimed to investigate the efficacy and safety of tucidinostat, 40 mg twice per week (BIW), in patients with relapsed/refractory (R/R) peripheral T-cell lymphoma (PTCL). The primary endpoint was overall response rate (ORR) assessed by an independent overall efficacy review committee. Between March 2017 and March 2019, 55 patients were treated, and 46 and 55 were evaluated for efficacy and safety, respectively. Twenty-one of 46 patients achieved objective responses with an ORR of 46% (95% confidence interval : 30.9-61.0), including five patients with complete response (CR). Responses were observed across various PTCL subtypes. In angioimmunoblastic T-cell lymphoma, there were two CR and five partial responses (PR) among eight patients, achieving an ORR of 88%. The disease control rate (CR + PR + stable disease) was 72% (33/46). The median progression-free survival, duration of response, and overall survival were 5.6 months, 11.5 months, 22.8 months, respectively. The most common adverse events (AE) (all grades) were thrombocytopenia, neutropenia, leukopenia, anemia, and diarrhea. The grade ≥3 AE emerging in ≥20% of patients included thrombocytopenia (51%), neutropenia (36%), lymphopenia (22%), and leukopenia (20%). Importantly, most of the AE were manageable by supportive care and dose modification. In conclusion, the favorable efficacy and safety profiles indicate that tucidinostat could be a new therapeutic option in patients with R/R PTCL (clinicaltrials gov. Identifier: NCT02953652).
Podcast como herramienta de enseñanza en la expresión oral en estudiantes de octavo de básica
Authors: Hidalgo Novillo Byron Stalin , Álvarez Lozano María Isabel
Published: October 2022

El uso del podcast en Latinoamérica y principalmente en Ecuador no son números alentadores en la audiencia, por eso es necesario educar a la comunidad para que puedan escuchar y producir podcast En la actualidad la sociedad exige un nivel de comunicación oral muy alto como de redacción escrita. La muestra para el estudio está compuesta por 34 estudiantes del octavo año de básica de la Unidad Educativa Remigio Crespo Toral. El diseño experimental del estudio fue de tipo cualitativo y cuantitativo por medio de una técnica e instrumento de toma de datos de la encuesta. Los datos obtenidos en el estudio se han procesado mediante el paquete estadístico SPSS versión 25 para el sistema operativo de Windows. Los análisis estadísticos aplicados sobre las muestran son los estadísticos descriptivos y frecuencia. Se determinan que no existen diferencia en cuanto al general todos consideran por arriba del 75% en la mayoría de las respuestas la importancia de esta herramienta educación sobre las clases siendo las mujeres las más motivadas en cuanto a este mecanismo de educación, de las respuestas una o una de las estudiantes. Debido a que eran encuestas anónimas no considera útil su utilización siendo conveniente indagar a futuro mecanismo para que englobe más la atención de los estudiantes.
Estudio de pre-factibilidad de una comercializadora de bebidas alcohólicas en Cuenca-Ecuador
Authors: Puma Guiracocha Wilson Fabián , Lugo García Jorge
Published: October 2022

El presente proyecto tiene como objetivo el de determinar un estudio de prefactibilidad para la creación de una comercializadora de bebidas alcohólicas en la avenida Remigio Crespo de la ciudad de Cuenca, teniendo como propósito satisfacer las necesidades de los consumidores, considerando como mercado objetivo todas las personas entre 18 años a 65 años de edad. Para fundamentar este proyecto, se utilizaron diferentes técnicas, que permitieron un mejor análisis e interpretación de la factibilidad del mismo. Seguidamente, se analizaron los aspectos correspondientes al estudio de mercado, viabilidad comercial y estudio técnico, donde se determinó el tamaño y la localización del proyecto, al igual que un estudio administrativo identificando la estructura organizacional, los roles, responsabilidades y la viabilidad comercial, que dio como resultado un mercado disponible positivo  y por ende una aceptación de los posibles consumidores; por lo tanto, como conclusión principal, se determina que, efectivamente  es factible la realización de este proyecto.
Rol de la personalidad y facilidades en la calidad percibida de los servicios: caso tecnicentros Cuenca
Authors: Calle Calle Marcelo , Hamilton Córdova Daniela
Published: October 2022

La investigación tuvo como objetivo entender ¿de qué manera la personalidad y las facilidades de los servicios, influyen en la calidad percibida por el consumidor del sector automotriz de la ciudad de Cuenca? Para esto, se identificaron tres variables de estudio; una variable dependiente denominada “calidad percibida”, y dos variables independientes que fueron “personalidad” y “facilidades de los servicios”. Para obtener los resultados, se realizó una recopilación de datos por medio de la aplicación de un cuestionario desarrollado a través de la adopción de preguntas ya validadas en cuestionarios revisados en la literatura. La encuesta fue enviada a una base de datos de clientes facilitada por un tecnicentro de la localidad. A partir de los datos obtenidos y el análisis de resultados por medio de un software estadístico, se encontró que las variables “personalidad” y “facilidades”; influyen de manera positiva en la calidad percibida por el consumidor. Los resultados aportan al sector automovilístico; sin embargo, los empresarios de diferentes sectores también pueden optimizar estrategias ya existentes o formular otras que les permitan llegar al consumidor y satisfacer las necesidades, valorando los atributos que consideran importantes.

Palabras clave: Atributos, calidad percibida, facilidades, personalidad, tecnicentros

This research was carried out to understand, how the personality and the facilities of the services influence the quality perceived by the consumer of the automotive sector of the city of Cuenca? For this, three study variables were identified; a dependent variable called perceived quality and two independent variables called personality and facilities. To obtain the results, a data collection was carried out through the application of a questionnaire developed through the adoption of questions already validated in questionnaires reviewed in the literature. The survey was sent to a customer database provided by a local technical center. From the data obtained and the analysis of results through statistical software, it was found that the variables of personality and facilities; positively influence the quality perceived by the consumer. The results obtained in this study provide essential information for the leading automotive sector. However, entrepreneurs from different sectors can also use these results to optimize existing strategies or formulate new techniques that allow them to reach consumers and satisfy their needs, valuing the attributes they consider necessary.

Keywords: Attributes, perceived quality, facilities, personality, technicenter
Cálculo del riesgo de mercado, rendimiento esperado y fracaso empresarial en el sector de la construcción del Ecuador – periodo 2009-2019
Authors: Reyes Clavijo Marco Antonio , Tonon-Ordonez Luis Bernardo
Published: October 2022

La gestión de riesgos es un aspecto clave para las empresas. El objetivo del estudio fue determinar el riesgo de mercado, rendimiento esperado y fracaso empresarial en el sector de la construcción del Ecuador. El riesgo de mercado fue calculado por medio del coeficiente Beta, y se calculó el rendimiento mínimo esperado del sector por medio del modelo CAPM; además, el riesgo de fracaso  empresarial fue calculado por medio del modelo de Altman para mercados emergentes. La data fue obtenida de la Superintendencia de Compañías, Valores y Seguros en el periodo 2009-2019. El coeficiente Beta del sector de la construcción fue de 0,5733 y el rendimiento mínimo esperado de 8,29%. Se destaca que, en promedio, las empresas constructoras se encuentran en zona segura según el modelo de Altman (valores superiores a 7,07). Los indicadores muestran que el sector no es riesgoso, sin embargo, existe una alta cantidad de empresas en zona de riesgo.

Palabras claves: Altman; coeficiente Beta; fracaso empresarial; riesgo de mercado, sector de la construcción.

Abstract

The risk management is an important aspect for companies. The aimof this work is to determine the market risk, expected return and business failure in the construction sector in Ecuador. The market risk was calculated through the Beta coefficient, and the expected minimum return of the sector was calculated through the CAPM model. In addition, the risk of business failure was calculated using the Altman model for emerging markets. The data was obtained from the Superintendence of Companies, Securities and Insurance in the period 2009-2019. The Beta coefficient of the construction sector was 0,5733 and the minimum expected return was 8,29%. It is noteworthy that, on average, construction companies are in a safe zone according to the Altman model (values greater than 7,07). These indicators show that the sector is not risky, but it should be considered that there is a high number of companies in the risk zone.

Keywords: Altman, Beta coefficient, business failure, market risk, construction sector
PENERAPAN SISTEM PENGENDALIAN MANAJEMEN DI MASA PANDEMI COVID-19
Authors:   Universitas Surabaya Indonesia, Kristie Viona Agnita , Andono Fidelis Arastyo ,   Universitas Surabaya Indonesia
Published: October 2022

Research Purposes. The purpose of this research is to deeply investigate the MCS implementation and the possible changes/adjustments during the pandemic COVID-19 crisis in a company. Research Method. To deeply investigate the phenomenon, this research conducted a qualitative case study that used a company in food industrial sector. Research Result and Findings. The empirical findings depict that the changes in the working environment caused by the business strategy changes occurred as the response to the crisis. A more decentralised management control change should take place as the consequence of the changes. The adjustment or updating in more than one MCS tools alongside with the company’s leader as the key actor became the significant challenges for the company. This research contributes to the debate in MCS research, particularly during COVID-19 crisis time.
POTENSI LIMBAH POPOK BAYI SEBAGAI MATRIKS PENGONTROL PELEPASAN PUPUK UREA PADA TANAMAN CABAI
Authors: Ramdani Nurfika , Mustam Mariaulfa , Hijrah Amaliah Azis
Published: October 2022

The problem of disposable diaper waste is a serious problem that challenges the environment. Therefore, the researchers sought the utilization of diaper waste in agriculture. Efficiency of fertilizer absorption in plants in the environment by 30-40%, remaining in the air and evaporating into ammonia gas. Utilization of baby diaper waste as a matrix and urea as a filler was carried out in this study. This is expected to be able to control the release of nitrogen in fertilizers in accordance with the amount and amount needed by plants (desorption) and maintain nitrogen requirements in the soil, so that the amount of fertilizer given is more efficient than conventional methods. How the purpose of this research is how to make fertilizer based on diaper waste, determine Nitrogen adsorption capacity into the matrix and determine the fertilizer requirements for growing chilli seedlings. The study was divided into 5 stages, the processing of baby diaper waste; second, the manufacture of urea larvae (fillers); three, filling the filler into the matrix; Rate, determine the Nitrogen adsorption capacity into the matrix; discuss, test on plants. The research results obtained are variations in the contribution of urea used as fillers is 15%. Based on this research, it can be said that diaper waste has the potential to control the release of urea. Furthermore, it can explain the rate of release of urea in chili plants.
PENGARUH LAMA WAKTU PERENDAMAN MENGGUNAKAN URINE SAPI TERHADAP PERKECAMBAHAN BIJI LAMTORO TARRAMBA (Leucaena leucocephala CV. Tarramba)
Authors: Susan Belipati  , Thomas Lapenangga  , Vertygo Stormy
Published: October 2022

The study was conducted to determine the difference in immersion time in cow urine on the percentage of germination, the average germination rate and the rate of germination growth. This study used a completely randomized design (CRD) with 4 treatments and 4 replications. The treatments were P0: Immersion in cow urine without time, P1: Immersion in cow urine for 30 minutes, P2: Immersion in cow urine for 60 minutes and P3: Immersion in cow urine for 90 minutes. The parameters in this study were the percentage of germination, the average germination rate and the growth rate of germination. Data on percentage germination, mean germination rate and growth rate of germination were analyzed using Analysis of Variance (ANOVA) and for growth rate of germination continued using Duncan's test. The results showed that the immersion time of lamtoro seeds in cow urine had a significant effect (P<0.05) on the average germination rate, but had no significant effect (P>0.05) on the percentage of germination and growth rate of germination. The best result was given by P3 treatment that gave the highest germination rate of 0.525 seed/day compared to the control which was only 0.428 seed/day. Nonetheless, it is still recommended to use cow urine to immerse seeds for 90 minutes particularly to enhance its germination rate. This research could hopefully give a useful reference for farmers as an alternative method of technology in cultivating animal feed plants for a better and improved productivity.
ANALISIS KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA KELAS IX DALAM MENYELESAIKAN SOAL PISA BERDASARKAN LANGKAH POLYA
Authors: Agustina Putri , Imami Adi Ihsan
Published: October 2022

The study was intended to determine the ability to solve the mathematics problems of students in public school 2 kutawaluya using the Polya steps. The methods used in this study are qualitative, describing the ability to solve a student's problem. Data collection techniques conducted in this study include tests, interviews, and documentation. From tests done by students, 3 research samples are divided into high, moderate, and low categories. From these three samples will be interviewed, and then will be picked up documenting during research as evidence that researchers have observed. After data collection, researchers will perform a data analysis with the following step: classifying data, classifying data, disposing of unused data, the presentation of data by compiling what has already been obtained, and the last to draw conclusions in the form of a sentence, which is obtained from the data's menu. Research shows: the student with the high problem-solving capability category is poorly researched in determining formulas, the student in the category is not reexamining the established completion and is also inmeticulous in writing conclusions at one problem, and the student with low valve-problem solving capabilities, is still less able to understand the problem, plan the problem, solve the problem and reexamine it.
PENGOLAHAN MINYAK JELANTAH SEBAGAI PENGGANTI BAHAN BAKAR MINYAK PADA KOMPOR MINYAK BERTEKANAN
Authors: Hikmah Nurhikmah
Published: October 2022

Used cooking oil (Jelantah's oil) is a frying rest oil which can't be used again to fry because it contains compounds that are quite dangerous for human health, which can be destructive for humans healthy. Beside to reduce an ambient contamination, used cooking oil can be recycled as an alternative fuel, in this case as to replace kerosene. The purpose of this study was to determine the effect of the primary Air Fuel Ratio on the combustion process in pressurized stove oil and knowing whether or not the direct combustion process of used cooking oil as an alternative fuel. The filth on used cooking oil must be removed to avoid a streaming gagging on koil. Analyzing used cooking oil water rate. Fuel tank loaded with used cooking oil. Fill the compressor with an air to pressurize the fuel tank.  Used cooking oil streamed inside the tank by manages flow rate then stream air with regulatory crane so up to scale which particular on flowmeter gases. Ruled air flow rate with scales regulatory crane flowmeter until up to stable state on appreciative given. Measuring temperature on burn tool with positioning different one (Spuyer, burner, burner's tip, kindled tip). The larger the primary Air Fuel Ratio, the better the mixing so that the total conversion of triglycerides into CO2 and CO products is greater. Used cooking oil may be directly used as an alternative fuel into an oil stove, especially pressured oil stove.
PEMANFAATAN LIMBAH TONGKOL JAGUNG MELALUI PENAMBAHAN EKSTRAK DAUN KERSEN (Muntingia Calabura) DALAM PEMBUATAN EDIBLE FILM
Authors: Latifah Rais Nur , Nurmilatillah
Published: October 2022

Food is a product that is synonymous with packaging techniques to protect the quality of the food. The packaging technique used edible film. This study aims to make a food protective coating from corn cobs and cherry leaf extract. The research method used the preparation of edible film, functional group analysis with FTIR instrument, mechanical properties analysis, pH testing and antibacterial properties analysis. The results showed that the edible film contains flavonoid compounds with antibacterial activity. The results of the analysis of the identification of functional groups on edible films are the presence of typical absorption of hydroxide groups, C-H groups, carbonyl groups and glycosidic bonds. Analysis of the mechanical properties of edible film for the thickness level is 0.224 mm and the tensile strength is 3.855 N/cm2. Meanwhile, based on pH testing, edible films were at a neutral pH during a 10-day storage period.
PENDEKATAN ICARE (INTRODUCTION, CONNECTION, APPLICATION, REFLECTION, EXTENSION) DALAM LKPD PELAJARAN MATEMATIKA KELAS VII SMP
Authors: Luvi Antari  , Syaifudin  , Nia Pusvitasari
Published: October 2022

This study aims to produce worksheets based on the ICARE approach that are valid and practical and have a potential effect on algebraic arithmetic operations material. This research is a development research or Development Research. The LKPD development process goes through two stages, namely the preliminary stage and the formative evaluation stage. The LKPD was declared valid after being validated by three experts based on: 1. ICARE characteristics, 2. The suitability of the material to basic competencies and indicators of competency achievement, and 3. Grammatical compatibility according to the General Guidelines for Indonesian Spelling (PUEBI). While the practicality of LKPD is seen from the responses of students in small groups in answering questions. The potential effect is seen from the results of students' final ability tests. student learning outcomes obtained an average final grade of  85.35 which means that student learning outcomes are classified as very good. So it can be concluded that the ICARE approach-based worksheets that have been developed have a potential effect on student learning outcomes.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD MELALUI TEKNIK HANDS ON MATHEMATICS BERBANTUAN LKS TERHADAP PEMAHAMAN KONSEP DAN PEMECAHAN MASALAH
Authors: Teni Suriani  , Yulia Rahmawati Z
Published: October 2022

This study aims to describe students' mathematical abilities assisted by LKS with the STAD type cooperative learning model through the Hand On Mathematical technique. Researchers used a quantitative approach in the form of Quasi Experiment. The study population was class VIII SMP N 43 Padang and the samples of this study were students of class VIII.1 as the experimental group who received treatment with the STAD type cooperative learning model through hand on mathematics techniques and VIII.2 as the control class who received conventional learning. The research instrument is in the form of a final test to see the understanding of mathematical concepts and problem solving. The results of the analysis show that: 1) The understanding of mathematical concepts taught by the STAD-type cooperative learning model through the hand on mathematics technique with LKS-assisted is better than that taught by conventional learning, 2) The mathematical problem-solving ability taught by the STAD-type cooperative learning model through the STAD-type cooperative learning technique. Hand on mathematics assisted by LKS is better than what is taught with conventional learning in class VIII SMP N 43 Padang.
DESKRIPSI KEMAMPUAN PEMAHAMAN MATEMATIS SISWA DALAM MENYELESAIKAN SOAL EKSPONEN KELAS X SMA
Authors: Rostiana Imelda Agustin , Indrie Noor Aini
Published: October 2022

This research is to describe the mathematical understanding ability of high school students on exponential material based on the achievement of each indicator of mathematical understanding. This type of research is a qualitative descriptive research. The subjects in this study were high school students Class X for the academic year 2021/2022 in the Karawang area which consisted of 3 students. The research sample was obtained through a purposive sampling technique, namely taking samples with certain considerations. The data collection technique used a test instrument which consisted of 3 description questions. Data were analyzed descriptively. The data analysis technique used is qualitative data analysis with data reduction steps, data presentation and conclusion drawing. The results of the analysis of this study indicate that the ability of students to solve exponential problems based on indicators of understanding is quite good. The results showed that on average students were able to understand the problem, students were able to understand the concept of the exponential equation, and students were able to adjust the exponential equation formula to the problem solving. However, there are errors where students have not been able to determine the set of solutions correctly.
PENGEMBANGAN BAHAN AJAR SUBTEMA INDAHNYA KERAGAMAN BUDAYA DINEGERIKU UNTUK MENINGKATKAN KARAKTER CINTA TANAH AIR PADA SISWA KELAS IV SD
Authors: Nella Audina Kusuma Citra  , Alfi Laila  , Rian Damariswara
Published: October 2022

The background of this research is the observation that 30% of students KKM and 70% KKM, students who are less disciplined in doing and collecting assignments, speak impolitely, do not care about the troubles of their friends. The aims of this study are (1) to determine the validity, practicality and effectiveness of the product development of teaching materials for students with the sub-theme of the beauty of cultural diversity in my country to improve the character of love for the homeland in fourth grade elementary school students in the 2020/2021 academic year? Research and development (research and development) ADDIE model. Subjects 40 students. The research site is Lirboyo 2 Elementary School, Kediri City. Statistical analysis analysis techniques. It was concluded that: 1) The validity of the product development of student teaching materials with the sub-theme of the beauty of cultural diversity in my country to improve the character of love for the homeland in students, with a score of 92-96. 2) The effectiveness of the product development of student teaching materials with the sub-theme of the beauty of cultural diversity in my country to improve the character of love for the homeland in students, with the average score of student test results being 83.12 > 75 above the KKM. 2) The practicality of product development of student teaching materials with the sub-theme of the beauty of cultural diversity in my country to improve the character of love for the homeland in students, with a score of 88.
Segmentação formal e pentatonismo harmônico em Sgt. Peppers Lonely Hearts Club Band
Authors: Visconti Ciro
Published: October 2022

Esse artigo é dedicado a fazer uma análise da forma musical e dos encadeamentos harmônicos da canção “Sgt. Pepper’s Lonely Hearts Club Band”, primeira faixa do álbum homônimo, e de sua Reprise que ocorre na faixa 12. Na análise formal serão usados conceitos da teoria das funções formais desenvolvidas por William Caplin para o repertório clássico e adaptada para a análise de Rock por Drew Nobile. As duas faixas serão primeiramente consideradas em separado, mas depois analisadas como sendo uma única canção. Na análise harmônica serão utilizados conceitos desenvolvidos por Walter Everett e Nicole Biamonte em que os acordes são gerados a partir das notas das pentatônicas.
A Unidade da obra musical a partir da Metafísica de Aristóteles
Authors: Wegmann Paul , Rodrigues Indioney
Published: October 2022

No presente artigo busca-se introduzir uma discussão sobre a unidade da obra musical a partir dos sentidos primordiais propostos pelo filósofo na Metafísica. O problema é: Em que sentido a obra musical pode ser una, considerando os significados primordiais de uno discutidos por Aristóteles? A discussão se inicia em torno da noção de obra musical. A seguir, são introduzidos alguns aspectos do pensamento musical aristotélico para abordar, mais tarde, a continuidade como sentido primordial de unidade e posteriormente desdobrar a contemplação do problema da unidade musical em apontamentos distintos concentrados na noção de variedade e no problema do belo. Por fim, sobre essas bases, também são introduzidas algumas questões relativas ao problema da unidade enquanto valor representado. Espera-se que este trabalho estimule reflexões filosóficas sobre problemas composicionais e contribua na discussão sobre a unidade da obra musical.
Relembrando e relendo “Sgt. Pepper”
Authors: Assis Garcia Luiz Henrique , Meller Lauro , Lentz Da Silveira Monteiro Guilherme
Published: October 2022

Partindo da problematização do conceito de clássico, segundo Calvino (1993), o artigo discute como o LP “Sgt. Pepper’s Lonely Hearts Club Band” foi fruto de releituras que os Beatles fizeram de suas próprias raízes pessoais e artísticas, bem de como toda uma tradição que os precede, um marco entre a nostalgia e a inovação. Ao indagarmos por que algumas obras são consagradas e outras esquecidas, investigamos como a construção da reputação (BECKER, 2010), a fortuna crítica (ROKA, 2004), e as próprias efemérides (SILVA 2002; HARTOG 2013) entram em cena para examinar como Pepper tornou-se um clássico constantemente relembrado em meio às engrenagens da indústria cultural. Examinamos, assim, como aspectos musicais e extramusicais, no correr do tempo, propiciaram um impulso extra para que o álbum continue influente, prestigiado e fonte de releituras variadas aos 55 anos de seu lançamento.
Estudo comparativo de quatro versões de Julian Bream do “Nocturnal” de Benjamin Britten
Authors: Madeira Bruno
Published: October 2022

O artigo analisa quatro versões de Julian Bream (de 1967, 1978, 1993 e 2003) do “Nocturnal after John Dowland, op. 70”, de Benjamin Britten, comparando decisões interpretativas que divergem da partitura editada pelo próprio violonista (BRITTEN, 1965). Com essa comparação, objetiva-se compreender detalhes tanto da interpretação do “Nocturnal”, quanto do estilo e práticas interpretativas de Bream, reconhecendo que suas perspectivas e decisões musicais se renovam no decorrer do tempo. O trabalho também almeja fornecer subsídios para que a partitura seja percebida como uma obra ainda incompleta, que é plenamente realizada apenas quando há a ação do intérprete/performer.
Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery
Authors: Marano Nicholas , Holaska James M.
Published: October 2022

X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery. Myogenic differentiation is a tightly regulated process characterized by genomic reorganization leading to coordinated temporal expression of key transcription factors, including MyoD, Pax7, and Myf5. Emerin was shown to interact with repressive histone modification machinery, including HDAC3 and EZH2. Using emerin-null myogenic progenitor cells we established several EDMD-causing emerin mutant lines in the effort to understand how the functional interaction of emerin with HDAC3 regulates histone methyltransferase localization or function to organize repressive chromatin at the nuclear periphery. We found that, in addition to its interaction with HDAC3, emerin interacts with the histone methyltransferases EZH2 and G9a in myogenic progenitor cells. Further, we show enhanced binding of emerin HDAC3-binding mutants S54F and Q133H to EZH2 and G9a. Treatment with small molecule inhibitors of EZH2 and G9a reduced H3K9me2 or H3K27me3 throughout differentiation. EZH2 and G9a inhibitors impaired cell cycle withdrawal, differentiation commitment, and myotube formation in wildtype progenitors, while they had no effect on emerin-null progenitors. Interestingly, these inhibitors exacerbated the impaired differentiation of emerin S54F and Q133H mutant progenitors. Collectively, these results suggest the functional interaction between emerin and HDAC3, EZH2, and G9a are important for myogenic differentiation.
BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain
Authors: Nguyen Huong , Sokpor Godwin , Parichha Arpan , Pham Linh , Saikhedkar Nidhi , Xie Yuanbin , Ulmke Pauline Antonie , Rosenbusch Joachim , Pirouz Mehdi , Behr Rüdiger , Stoykova Anastassia , Brand-Saberi Beate , Nguyen Huu Phuc , Staiger Jochen F. , Tole Shubha , Tuoc Tran
Published: October 2022

Early forebrain patterning entails the correct regional designation of the neuroepithelium, and appropriate specification, generation, and distribution of neural cells during brain development. Specific signaling and transcription factors are known to tightly regulate patterning of the dorsal telencephalon to afford proper structural/functional cortical arealization and morphogenesis. Nevertheless, whether and how changes of the chromatin structure link to the transcriptional program(s) that control cortical patterning remains elusive. Here, we report that the BAF chromatin remodeling complex regulates the spatiotemporal patterning of the mouse dorsal telencephalon. To determine whether and how the BAF complex regulates cortical patterning, we conditionally deleted the BAF complex scaffolding subunits BAF155 and BAF170 in the mouse dorsal telencephalic neuroepithelium. Morphological and cellular changes in the BAF mutant forebrain were examined using immunohistochemistry and in situ hybridization. RNA sequencing, Co-immunoprecipitation, and mass spectrometry were used to investigate the molecular basis of BAF complex involvement in forebrain patterning. We found that conditional ablation of BAF complex in the dorsal telencephalon neuroepithelium caused expansion of the cortical hem and medial cortex beyond their developmental boundaries. Consequently, the hippocampal primordium is not specified, the mediolateral cortical patterning is compromised, and the cortical identity is disturbed in the absence of BAF complex. The BAF complex was found to interact with the cortical hem suppressor LHX2. The BAF complex suppresses cortical hem fate to permit proper forebrain patterning. We provide evidence that BAF complex modulates mediolateral cortical patterning possibly by interacting with the transcription factor LHX2 to drive the LHX2-dependent transcriptional program essential for dorsal telencephalon patterning. Our data suggest a putative mechanistic synergy between BAF chromatin remodeling complex and LHX2 in regulating forebrain patterning and ontogeny.
Cytotoxic mixed-ligand complexes of Cu(II): A combined experimental and computational study
Authors: Alem Mamaru Bitew , Damena Tadewos , Desalegn Tegene , Koobotse Moses , Eswaramoorthy Rajalakshmanan , Ngwira Kennedy J. , Ombito Japheth O. , Zachariah Matshediso , Demissie Taye B.
Published: October 2022

Herein, we report the synthesis of mixed-ligand Cu(II) complexes of metformin and ciprofloxacin drugs together with 1,10-phenanthroline as a co-ligand. The synthesized complexes were characterized using different spectroscopic and spectrometric techniques. In vitro cytotoxic activity against human breast adenocarcinoma cancer cell line (MCF-7) as well as antibacterial activity against two gram-negative and two gram-positive bacterial strains were also investigated. The analyses of the experimental results were supported using quantum chemical calculations and molecular docking studies against estrogen receptor alpha (ERα; PDB: 5GS4). The cytotoxicity of the [Cu(II) (metformin) (1,10-phenanthroline)] complex (1), with IC50 of 4.29 µM, and the [Cu(II) (ciprofloxacin) (1,10-phenanthroline)] complex (2), with IC50 of 7.58 µM, were found to be more effective than the referenced drug, cisplatin which has IC50 of 18.62 µM against MCF-7 cell line. The molecular docking analysis is also in good agreement with the experimental results, with binding affinities of –7.35, –8.76 and –6.32 kcal/mol, respectively, for complexes 1, 2 and cisplatin against ERα. Moreover, complex 2 showed significant antibacterial activity against E. coli (inhibition diameter zone, IDZ, = 17.3 mm), P. aeruginosa (IDZ = 17.08 mm), and S. pyogen (IDZ = 17.33 mm), at 25 μg/ml compared to ciprofloxacin (IDZ = 20.0, 20.3, and 21.3 mm), respectively. Our BOILED-egg model indicated that the synthesized metal complexes have potentially minimal neurotoxicity than that of cisplatin.
Features of the oral microbiome in Japanese elderly people with 20 or more teeth and a non-severe periodontal condition during periodontal maintenance treatment: A cross-sectional study
Authors: Toyama Naoki , Ekuni Daisuke , Yokoi Aya , Fukuhara Daiki , Islam Md Monirul , Sawada Nanami , Nakashima Yukiho , Nakahara Momoko , Sumita Ichiro , Morita Manabu
Published: October 2022

Introduction

The aim of the present study was to characterize the profile and diversity of the oral microbiome of a periodontally non-severe group with ≥20 teeth in comparison with a severe periodontitis group of elderly Japanese people.

Methods

A total of 50 patients who had ≥20 teeth and aged ≥60 years were recruited, and 34 participants (13 non-severe participants) were analyzed. After oral rinse (saliva after rinsing) sample collection, the V3–V4 regions of the 16S rRNA gene were sequenced to investigate microbiome composition, alpha diversity (Shannon index, Simpson index, richness, and evenness), and beta diversity using principal coordinate analysis (PCoA) based on weighted and unweighted UniFrac distances. A linear discriminant analysis effect size was calculated to identify bacterial species in the periodontally non-severe group.

Results

The periodontally non-severe group showed lower alpha diversity than that of the severe periodontitis group (p <0.05); however, the beta diversities were not significantly different. A higher relative abundance of four bacterial species (Prevotella nanceiensis, Gemella sanguinis, Fusobacterium periodonticum, and Haemophilus parainfluenzae) was observed in the non-severe group than that in the severe periodontitis group.

Conclusion

The oral microbiome in elderly Japanese people with ≥20 teeth and a non-severe periodontal condition was characterized by low alpha diversity and the presence of four bacterial species.
Epidemic, risk factors of carbapenem-resistant Klebsiella pneumoniae infection and its effect on the early prognosis of liver transplantation
Authors: Liu Ning , Yang Gengxia , Dang Yan , Liu Xin , Chen Ming , Dai Fangfang , Ding Xiurong , Li Wenlei , Li Guangming , Lou Jinli , Chen Dexi , Yu Yanhua
Published: October 2022

Background

Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection remains a major cause of morbidity and mortality in early-stage post-liver transplantation (LT).

Methods

We retrospectively analyzed the demographic and clinical infections characteristics of all LT recipients in our hospital between January 2019 and December 2021.

Results

Among the 272 LT recipients who received LT between January 2019 and December 2021, sixty-two patients had at least one infection within 3-months post-LT, with a prevalence of 22.8% (62/272). The prevalence of CRKP infections was 7.0% (19/272), and the 3-months post-LT mortality was 19.4% (12/62). The risk factors independently related to 3-months mortality were age (Odds ratio (OR)= 1.126, 95% Confidence interval (CI): 1.009~1.257; P=0.034), mechanical ventilation (MV) (OR=1.206, 95% CI: 1.039~1.401; P =0.014), and CRKP infection (OR=18.240, 95% CI: 2.206~150.842; P =0.007). In CRKP infection, the length of ICU stay (OR=1.067, 95% CI: 1.015~1.122; P=0.011), pre-operation infection (POI) (OR=6.733, 95% CI: 1.160~39.088; P=0.034), and hepatocellular carcinoma (HCC) (OR=26.772, 95% CI: 1.747~410.187; P=0.018) were the independent risk factors. With COX multivariate regression analysis, the 3-months survival rate of CRKP infected patients was significantly lower than that without CRKP infection post-LT.

Conclusions

CRKP infection is closely correlated with poor prognosis in 3-months post-LT.
Targeting GPCRs to treat cardiac fibrosis
Authors: Zhang Hao , Ren Lu , Shivnaraine Rabindra Vishwadev
Published: October 2022

Cardiac fibrosis occurs ubiquitously in ischemic heart failure, genetic cardiomyopathies, diabetes mellitus, and aging. It triggers myocardial stiffness, which impairs cardiac function, ultimately progressing to end-stage heart failure and increased mortality. Although several targets for anti-fibrotic therapies have been identified, including TGF-β and receptor tyrosine kinase, there is currently no FDA-approved drug specifically targeting cardiac fibrosis. G protein-coupled receptors (GPCRs) are integral, multipass membrane-bound receptors that exhibit diverse and cell-specific expression, offering novel and unrealized therapeutic targets for cardiac fibrosis. This review highlights the emerging roles of several GPCRs and briefly explores their downstream pathways that are crucial in cardiac fibrosis. We will not only provide an overview of the GPCRs expressed on cardiac fibroblasts that are directly involved in myofibroblast activation but also describe those GPCRs which contribute to cardiac fibrosis via indirect crosstalk mechanisms. We also discuss the challenges of identifying novel effective therapies for cardiac fibrosis and offer strategies to circumvent these challenges.
Simultaneous multi-parametric acquisition and reconstruction techniques in cardiac magnetic resonance imaging: Basic concepts and status of clinical development
Authors: Eyre Katerina , Lindsay Katherine , Razzaq Saad , Chetrit Michael , Friedrich Matthias
Published: October 2022

Simultaneous multi-parametric acquisition and reconstruction techniques (SMART) are gaining attention for their potential to overcome some of cardiovascular magnetic resonance imaging’s (CMR) clinical limitations. The major advantages of SMART lie within their ability to simultaneously capture multiple “features” such as cardiac motion, respiratory motion, T1/T2 relaxation. This review aims to summarize the overarching theory of SMART, describing key concepts that many of these techniques share to produce co-registered, high quality CMR images in less time and with less requirements for specialized personnel. Further, this review provides an overview of the recent developments in the field of SMART by describing how they work, the parameters they can acquire, their status of clinical testing and validation, and by providing examples for how their use can improve the current state of clinical CMR workflows. Many of the SMART are in early phases of development and testing, thus larger scale, controlled trials are needed to evaluate their use in clinical setting and with different cardiac pathologies.
Training intensity influences left ventricular dimensions in young competitive athletes
Authors: Weberruß Heidi , Baumgartner Lisa , Mühlbauer Frauke , Shehu Nerejda , Oberhoffer-Fritz Renate
Published: October 2022

Background

In young athletes, exercise causes changes in the heart that include growth in wall thickness and mass of the left ventricle and expansion of the heart’s chambers. The heart’s function is either preserved or enhanced, but this may change to the opposite over time.

Objective

This study aimed to assess structural and functional cardiac adaptations in relation to exercise training time, intensity, and performance in young competitive athletes.

Methods

A total of 404 children and adolescents (14.23 ± 2.0 years, 97 females) were enrolled in the Munich Cardiovascular Adaptations in Young Athletes Study (MuCAYA-Study). Eighty-five participants were examined two times a year. Two-dimensional echocardiography was performed to assess left ventricular structure and function. Training time and intensity was measured with the MoMo physical activity questionnaire, maximum aerobic capacity by cardiopulmonary exercise testing, and strength with the handgrip strength test.

Results

Maximum aerobic capacity significantly influenced interventricular septal thickness in diastole. Training intensity significantly influenced left ventricular internal diameter in diastole and systole, and left ventricular mass indexed to body surface area. Within one year, interventricular wall thickness, relative wall thickness and left ventricular mass, indexed to body surface area and height, increased significantly. Training intensity and aerobic capacity contributed to cardiac adaptations in young competitive athletes, as represented by altered structural parameters but preserved cardiac function. Within a year, however, structural changes and a decline in diastolic performance were observed within the longitudinal sub-sample.

Conclusion

Our results confirm the hypothesis that cardiac adaptations to exercise occur at a young age. Cardiac adaptation in our cohort was influenced by exercise intensity and maximum aerobic capacity.
Biomarker-based approach to determine etiology and severity of pulmonary hypertension: Focus on microRNA
Authors: Rogula Sylwester , Pomirski Bartosz , Czyżak Norbert , Eyileten Ceren , Postuła Marek , Szarpak Łukasz , Filipiak Krzysztof J. , Kurzyna Marcin , Jaguszewski Miłosz , Mazurek Tomasz , Grabowski Marcin , Gąsecka Aleksandra
Published: October 2022

Pulmonary arterial hypertension (PAH) is characterized by remodeling of the pulmonary arteries, and defined by elevated pulmonary arterial pressure, measured during right heart catheterization. There are three main challenges to the diagnostic and therapeutic process of patients with PAH. First, it is difficult to differentiate particular PAH etiology. Second, invasive diagnostic is required to precisely determine the severity of PAH, and thus to qualify patients for an appropriate treatment. Third, the results of treatment of PAH are unpredictable and remain unsatisfactory. MicroRNAs (miRNAs) are small non-coding RNAs that regulate post transcriptional gene-expression. Their role as a prognostic, and diagnostic biomarkers in many different diseases have been studied in recent years. MiRNAs are promising novel biomarkers in PAH due to their activity in various molecular pathways and processes underlying PAH. Lack of biomarkers to differentiate between particular PAH etiology and evaluate the severity of PAH, as well as paucity of therapeutic targets in PAH open a new field for the possibility to use miRNAs in these applications. In our article, we discuss the potential of miRNAs use as diagnostic tools, prognostic biomarkers and therapeutic targets in PAH.