bluuebunny/crossref_metadata_2025 huggingface dataset:
From Victimization to Fear: Fear of Crime and its Variations Among Victims
Authors: Noble Julien , Jardin Antoine
Published: June 2019

The relations between victimization and fear of crime are traditionally studied using binary combinations. Research focuses on whether the fact of having suffered a victimization increases the risk of being afraid, without ever considering the variety of profiles of victimization. We propose to contribute to an elucidation of this phenomenon by examining a group of victims of theft and assault using the accumulated data of systematically repeated victimization surveys in France, and classing these individuals according to the type and intensity of the victimization experienced. We will then look at the relationship between fear of crime and these different profiles. The results show the absence of a single, homogeneous correlation, but rather, the existence of a variety of patterns linking these two variables.
The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis
Authors: Saad Mohamed I , McLeod Louise , Yu Liang , Ebi Hiromichi , Ruwanpura Saleela , Sagi Irit , Rose-John Stefan , Jenkins Brendan J
Published: June 2019

Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and receptors, and therefore is an attractive target in cancer. However, the role of ADAM17 in promoting tobacco smoke carcinogen-induced lung carcinogenesis is unknown. The hypomorphic Adam17ex/ex mice—characterized by reduced global ADAM17 expression—were backcrossed onto the NNK-sensitive pseudo-A/J background. CRISPR-driven and inhibitor-based (GW280264X, and ADAM17 prodomain) ADAM17 targeting was employed in the human lung adenocarcinoma cell lines A549 and NCI-H23. Human lung cancer biopsies were also used for analyses. The Adam17ex/ex mice displayed marked protection against NNK-induced lung adenocarcinoma. Specifically, the number and size of lung lesions in NNK-treated pseudo-A/J Adam17ex/ex mice were significantly reduced compared with wild-type littermate controls. This was associated with lower proliferative index throughout the lung epithelium. ADAM17 targeting in A549 and NCI-H23 cells led to reduced proliferative and colony-forming capacities. Notably, among select ADAM17 substrates, ADAM17 deficiency abrogated shedding of the soluble IL-6 receptor (sIL-6R), which coincided with the blockade of sIL-6R-mediated trans-signaling via ERK MAPK cascade. Furthermore, NNK upregulated phosphorylation of p38 MAPK, whose pharmacological inhibition suppressed ADAM17 threonine phosphorylation. Importantly, ADAM17 threonine phosphorylation was significantly upregulated in human lung adenocarcinoma with smoking history compared with their cancer-free controls. Our study identifies the ADAM17/sIL-6R/ERK MAPK axis as a candidate therapeutic strategy against tobacco smoke-associated lung carcinogenesis.
Breakdown of Whole-brain Dynamics in Preterm-born Children
Authors: Padilla Nelly , Saenger Victor M , van Hartevelt Tim J , Fernandes Henrique M , Lennartsson Finn , Andersson Jesper L R , Kringelbach Morten , Deco Gustavo , Åden Ulrika
Published: June 2019

The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at < 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a whole-brain Hopf model, to define the level of stability, desynchronization, or criticality of the brain. EPT-born children exhibited fewer intrinsic ignition events than controls; nodes were related to less sophisticated aspects of cognitive control, and there was a different hierarchy pattern in the propagation of information and suboptimal synchronicity and criticality. The largest differences were found in brain nodes belonging to the rich-club architecture. These results provide important insights into the neural substrates underlying brain reorganization and neurodevelopmental impairments related to prematurity.
Bioinformatics Discovery of Putative Enhancers within Mouse Odorant Receptor Gene Clusters
Authors: Farber James E , Lane Robert P
Published: June 2019

Olfactory neuronal function depends on the expression and proper regulation of odorant receptor (OR) genes. Previous studies have identified 54 putative intergenic enhancers within or flanking 40 mouse OR clusters. At least 2 of these putative enhancers have been shown to regulate the expression of a small subset of proximal OR genes. In recognition of the large size of the mouse OR gene family (~1400 OR genes distributed across multiple chromosomal loci), it is likely that there remain many additional not-as-yet discovered OR enhancers. We utilized 23 of the previously identified enhancers as a training set (TS) and designed an algorithm that combines a broad range of epigenetic criteria (histone-3-lysine-4 monomethylation, histone-3-lysine-79 trimethylation, histone-3-lysine-27 acetylation, and DNase hypersensitivity) and genetic criteria (cross-species sequence conservation and transcription-factor binding site enrichment) to more broadly search OR gene clusters for additional candidates. We identified 181 new candidate enhancers located at 58 (of 68) mouse OR loci, including 25 new candidates identified by stringent search criteria whose signal strengths are not significantly different from the 23 previously characterized OR enhancers used as the TS. Additionally, we compared OR enhancer versus generic enhancer features in order to evaluate likelihoods that new enhancer candidates specifically function in OR regulation. We found that features distinguishing OR-specific function are significantly more evident for enhancer candidates located within OR clusters as compared with those in flanking regions.
The Accumulation and Transfers of Wealth: Variations by Social Class
Authors: Hansen Marianne Nordli , Wiborg Øyvind Nicolay
Published: June 2019

The purpose of our study is to investigate the role of wealth in broader stratification processes. Based on unique data from Norwegian tax registers, we address questions about the association between class origin, wealth transfers, and wealth accumulation among young adults. We show that is more common to receive transfers in the higher than in the lower social classes, and that those originating in the economic upper class, i.e. large proprietors, owners, of single enterprises as well as investors with diversified portfolios, and top managers and directors, are especially likely to receive transfers, as well as especially large inter vivos gifts. As young adults, those with upper-class origins, and especially origins in the economic upper class, accumulate more wealth than those with origins in classes lower in the social hierarchy. In all social classes, those who have received wealth transfers accumulate most wealth. We argue that transferring wealth indeed appears as robust and efficient mobility or reproduction strategy.
Mortality among Italian male workers in the construction industry: a census-based cohort study
Authors: Alicandro Gianfranco , Bertuccio Paola , Sebastiani Gabriella , La Vecchia Carlo , Frova Luisa
Published: June 2019

Background

Advances in technologies, occupational hygiene and increased surveillance have reduced the excess mortality previously found in the construction industry. This study is aimed to evaluate cause-specific mortality in a recent cohort of construction workers.

Methods

We carried out a record-linkage cohort study based on the 2011 Italian census and the mortality archives (2012–2015), including 1 068 653 construction workers. We estimated mortality rate ratios (MRR) using Poisson regression models including terms for age and geographic area.

Results

Compared with non-manual workers, construction workers showed an excess mortality from all causes (MRR: 1.34), all neoplasms (MRR: 1.30), head and neck (MRR: 2.05), stomach (MRR: 1.56), liver (MRR: 1.62), lung (MRR: 1.80), prostate (MRR: 1.24) and bladder (MRR: 1.60) cancers, respiratory (MRR: 1.41) and liver (MRR: 1.79) diseases, all external causes (MRR: 1.87), falls (MRR: 2.87) and suicide (MRR: 1.58). Compared with manual workers in other industries, construction workers showed excess mortality from prostate (MRR: 1.27) and non-melanoma skin cancers (MRR: 1.95), all external causes (MRR: 1.14), falls (MRR: 1.94) and suicide (MRR: 1.18). Most of this excess mortality disappeared after adjusting for education, with the exception of prostate and non-melanoma skin cancers, all external causes, falls and suicide.

Conclusions

Construction workers are at high risk of dying from external causes, while the excess mortality found for several cancers, liver and respiratory diseases may be at least partially due to the high prevalence of low education and unfavorable lifestyle factors. The excess mortality from prostate cancer requires further evaluations.
Salivary N-glycosylation as a biomarker of oral cancer: A pilot study
Authors: Sinevici Nicoleta , Mittermayr Stefan , Davey Gavin P , Bones Jonathan , O’Sullivan Jeff
Published: June 2019

Reliable biomarkers for oral cancer (OC) remain scarce, and routine tests for the detection of precancerous lesions are not routine in the clinical setting. This study addresses a current unmet need for more sensitive and quantitative tools for the management of OC. Whole saliva was used to identify and characterize the nature of glycans present in saliva and determine their potential as OC biomarkers. Proteins obtained from whole saliva were subjected to PNGase F enzymatic digestion. The resulting N-glycans were analyzed with weak anion exchange chromatography, exoglycosidase digestions coupled to ultra-high performance liquid chromatography and/or mass spectrometry. To determine N-glycan changes, 23 individuals with or without cancerous oral lesions were analyzed using Hydrophilic interaction ultra performance liquid chromatography (HILIC–UPLC), and peak-based area relative quantitation was performed. An abundant and complex salivary N-glycomic profile was identified. The main structures present in saliva were neutral oligosaccharides consisting of high mannose, hybrid and complex structures, followed by smaller fractions of mono and di-sialylated structures. To determine if differential N-glycosylation patterns distinguish between OC and control groups, Mann–Whitney testing and principle component analysis (PCA) were used. Eleven peaks were shown to be statistically significant (P ≤ 0.05), while PCA analysis showed segregation of the two groups based on their glycan profile. N-glycosylation changes are active in the oral carcinogenic process and may serve as biomarkers for early detection to reduce morbidity and mortality. Identifying which N-glycans contribute most in the carcinogenic process may lead to their use in the detection, prognosis and treatment of OC.
Still Enigmatic: Innate Immunity in the Ctenophore Mnemiopsis leidyi
Authors: Traylor-Knowles Nikki , Vandepas Lauren E , Browne William E
Published: June 2019

Innate immunity is an ancient physiological response critical for protecting metazoans from invading pathogens. It is the primary pathogen defense mechanism among invertebrates. While innate immunity has been studied extensively in diverse invertebrate taxa, including mollusks, crustaceans, and cnidarians, this system has not been well characterized in ctenophores. The ctenophores comprise an exclusively marine, non-bilaterian lineage that diverged early during metazoan diversification. The phylogenetic position of ctenophore lineage suggests that characterization of the ctenophore innate immune system will reveal important features associated with the early evolution of the metazoan innate immune system. Here, we review current understanding of the ctenophore immune repertoire and identify innate immunity genes recovered from three ctenophore species. We also isolate and characterize Mnemiopsis leidyi cells that display macrophage-like behavior when challenged with bacteria. Our results indicate that ctenophores possess cells capable of phagocytosing microbes and that two distantly related ctenophores, M. leidyi and Hormiphora californiensis, possess many candidate innate immunity proteins.
Validation of Eurolung risk models in a Japanese population: a retrospective single-centre analysis of 612 cases
Authors: Nagoya Akihiro , Kanzaki Ryu , Kanou Takashi , Ose Naoko , Funaki Soichiro , Minami Masato , Shintani Yasushi , Tsutsui Anna , Suga Sayaka , Tajima Tetsuya , Ohno Yuko , Okumura Meinoshin
Published: June 2019

OBJECTIVES

The objective of this study was to evaluate the validity of Eurolung risk models in a Japanese population and assess their utility as predictive indicators for the prognosis.

METHODS

Between 2007 and 2014, 612 anatomic lung resections were performed among 694 lung cancer patients in our institution. We analysed the cardiopulmonary morbidity and mortality and compared them with the predicted results. We also investigated the association between the Eurolung aggregate risk scores and the long-term outcomes using the Kaplan–Meier method and a multivariable analysis.

RESULTS

The percentage of cardiopulmonary complications was lower than that predicted by Eurolung 1 (22.4% vs 24.6%). The mortality rate was significantly lower than predicted by Eurolung 2 (0.7% vs 3.0%). The morbidity rate was stratified by Aggregate Eurolung 1. The stratification of the mortality rate by the Eurolung 2 aggregate score was also in line with the increase in score, although the observed number of deaths was quite small (4 cases). The 5-year overall survival was clearly separated according to the stratified Aggregate Eurolung 1 and 2 (P < 0.01 and P < 0.01, respectively). Besides pathological stage, both the Aggregate Eurolung 1 (score 0–7 vs 8–20) and 2 (score 0–8 vs 9–19) scores were shown to be independently associated with overall survival on multivariable.

CONCLUSIONS

Eurolung risk models cannot be directly applied to the patients in our institution. However, Eurolung aggregate risk scores were helpful not only for stratifying morbidity and mortality after anatomic lung resection but also for predicting the long-term outcomes.
Isotropic Cuspidal Functions in the Hall Algebra of a Quiver
Authors: Hennecart Lucien
Published: June 2019

From the structure of the category of representations of an affine cycle-free quiver, we determine an explicit linear form on the space of cuspidal regular functions over a finite field: its kernel is exactly the space of cuspidal functions. Moreover, we show that any isotropic cuspidal dimension has an affine support. Brought together, this two results give an explicit description of isotropic cuspidal functions of any quiver. The main theorem, together with an appropriate action of some permutation group on the Hall algebra, provides a new elementary proof of two conjectures of Berenstein and Greenstein previously proved by Deng and Ruan. We also prove a statement giving non-obvious constraints on the support of the comultiplication of a cuspidal regular function allowing us to connect both mentioned conjectures of Berenstein and Greenstein. Our results imply the positivity conjecture of Bozec and Schiffmann concerning absolutely cuspidal polynomials in isotropic dimensions.
Resistance to critically important antimicrobials in Australian silver gulls (Chroicocephalus novaehollandiae) and evidence of anthropogenic origins
Authors: Mukerji Shewli , Stegger Marc , Truswell Alec Vincent , Laird Tanya , Jordan David , Abraham Rebecca Jane , Harb Ali , Barton Mary , O’Dea Mark , Abraham Sam
Published: June 2019

Objectives

Antimicrobial resistance (AMR) to critically important antimicrobials (CIAs) amongst Gram-negative bacteria can feasibly be transferred amongst wildlife, humans and domestic animals. This study investigated the ecology, epidemiology and origins of CIA-resistant Escherichia coli carried by Australian silver gulls (Chroicocephalus novaehollandiae), a gregarious avian wildlife species that is a common inhabitant of coastal areas with high levels of human contact.

Methods

Sampling locations were widely dispersed around the perimeter of the Australian continent, with sites separated by up to 3500 km. WGS was used to study the diversity and molecular characteristics of resistant isolates to ascertain their epidemiological origin.

Results

Investigation of 562 faecal samples revealed widespread occurrence of extended-spectrum cephalosporin-resistant (21.7%) and fluoroquinolone-resistant (23.8%) E. coli. Genome sequencing revealed that CIA-resistant E. coli isolates (n = 284) from gulls predominantly belonged to human-associated extra-intestinal pathogenic E. coli (ExPEC) clones, including ST131 (17%), ST10 (8%), ST1193 (6%), ST69 (5%) and ST38 (4%). Genomic analysis revealed that gulls carry pandemic ExPEC-ST131 clades (O25:H4 H30-R and H30-Rx) and globally emerging fluoroquinolone-resistant ST1193 identified among humans worldwide. Comparative analysis revealed that ST131 and ST1193 isolates from gulls overlapped extensively with human clinical isolates from Australia and overseas. The present study also detected single isolates of carbapenem-resistant E. coli (ST410-blaOXA-48) and colistin-resistant E. coli (ST345-mcr-1).

Conclusions

The carriage of diverse CIA-resistant E. coli clones that strongly resemble pathogenic clones from humans suggests that gulls can act as ecological sponges indiscriminately accumulating and disseminating CIA-resistant bacteria over vast distances.
Distribution of Pheromone Biosynthesis-Activating Neuropeptide in the Central Nervous System of Plutella xylostella (Lepidoptera: Plutellidae)
Authors: Chen Yong , Liu Yuyan , Tian Houjun , Chen Yixin , Lin Shuo , Mao Qianzhuo , Zheng Nan , Zhao Jianwei , Gu Xiaojun , Wei Hui
Published: June 2019

Insect neuropeptides in the pyrokinin/pheromone biosynthesis-activating neuropeptide (PBAN) family are actively involved in many essential endocrinal functions and serve as potential targets in the search for novel insect control agents. Here, we dissect the nervous system of larval, pupal, and adult Plutella xylostella (L.) (Lepidoptera: Plutellidae) and describe the ganglion morphology and localization of PBAN during different insect developmental stages. Our results show that the central nervous system (CNS) of this species consists of four types of ganglia: cerebral ganglia (brain), subesophageal ganglion (SEG), thoracic ganglia, and abdominal ganglia. A two-lobed brain is connected to the reniform SEG with a nerve cord in larvae and prepupae, whereas in the late pupae and adults, the brain and SEG are fused, forming a brain–SEG complex. The larvae and prepupae have eight abdominal ganglia each, whereas the late pupae and adults each have four abdominal ganglia. Furthermore, all life stages of P. xylostella had similar patterns of PBAN immunoreactivity in the CNS, and the accumulation of PBAN was similar during all life stages except in adult males. PBAN immunoreactive signals were observed in the brain and SEG, and fluorescence signals originating in the SEG extended the entire length of the ventral nerve cord, ending in the terminal abdominal ganglia. Our results provide morphological data that inform the development and evolution of the CNS. In addition, they indicate that the nervous system contains PBAN, which could be used to control P. xylostella populations.
Host Potential and Adaptive Responses of Drosophila suzukii (Diptera: Drosophilidae) to Barbados Cherries
Authors: Mendonca Larine de Paiva , Oliveira Eugenio Eduardo , Andreazza Felipe , Rezende Sarah Miranda , Faroni Lêda Rita D’Antonino , Guedes Raul Narciso Carvalho , Haddi Khalid
Published: June 2019

Biological invasions are a global threat to agricultural crops worldwide. In the Neotropical region, the spotted-wing Drosophila [Drosophila suzukii (Matsumura)] has rapidly expanded its geographical range spreading throughout South America in recent years. Besides climatic factors, the remarkable success of its establishment and subsequent distribution in this region is closely dependent on the diversity and availability of host plants. We evaluated the host potential (e.g., as food and oviposition sources) of fruits of jabuticaba [Plinia cauliflora (Mart.) Kausel (Myrtales: Myrtaceae)], Barbados cherry (Malpighia emarginata DC) (Malpighiales: Malpighiaceae), bonnet pepper (Capsicum chinense Jacq.) (Solanales : Solanaceae), and coffee (Coffea arabica L.) (Gentianales : Rubiaceae) and their effects on the biological and physiological traits of D. suzukii. For the fruit types where fly emergence occurred, we assessed the biological and physiological performance of the flies and compared these parameters with those recorded for flies reared on strawberries (Fragaria × ananassa Duchesne) (Rosales : Rosaceae) and an artificial diet. Our results revealed that oviposition into fruits and completion of the life cycle occurred on Barbados cherries only. Furthermore, field surveys revealed a higher emergence rate of D. suzukii on undamaged ripe Barbados cherries than damaged ones. Moreover, flies developing on Barbados cherries and an artificial diet presented earlier emergence, shorter developmental time, lower number of adults per female, and a female-biased sex ratio compared to flies developing on strawberries. Overall, our findings demonstrated suitability of Barbados cherry as a host for D. suzukii, which renders management of D. suzukii in Neotropical region an even more challenging task.
The Case for Market-Based Stress Tests
Authors: Vickers John
Published: June 2019

The author contends that, for major banks with price-to-book ratios less than one, stress tests based on market values should be run and published by regulators alongside existing stress test results.
Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system
Authors: Xu Ya-Jie , Liu Pei-Pei , Ng Shyh-Chang , Teng Zhao-Qian , Liu Chang-Mei
Published: June 2019

High-throughput sequencing has facilitated the identification of many types of non-coding RNAs (ncRNAs) involved in diverse cellular processes. NcRNAs as epigenetic mediators play key roles in neuronal development, maintenance, and dysfunction by controlling gene expression at multiple levels. NcRNAs may not only target specific DNA or RNA for gene silence but may also directly interact with chromatin-modifying proteins like Polycomb group (PcG) proteins to drive orchestrated transcriptional programs. Recent significant progress has been made in characterizing ncRNAs and PcG proteins involved in transcriptional, post-transcriptional, and epigenetic regulation. More importantly, dysregulation of ncRNAs, PcG proteins, and interplay among them is closely associated with the pathogenesis of central nervous system (CNS) disorders. In this review, we focus on the interplay between ncRNAs and PcG proteins in the CNS and highlight the functional roles of the partnership during neural development and diseases.
Re-Examining the Middle Means Typical and the Left and Top Means First Heuristics Using Eye-Tracking Methodology
Authors: Höhne Jan Karem , Lenzner Timo , Neuert Cornelia E , Yan Ting
Published: June 2019

Web surveys are a common self-administered mode of data collection using written language to convey information. This language is usually accompanied by visual design elements, such as numbers, symbols, and graphics. As shown by previous research, such elements of survey questions can affect response behavior because respondents sometimes use interpretive heuristics, such as the “middle means typical” and the “left and top means first” heuristics when answering survey questions. In this study, we adopted the designs and survey questions of two experiments reported in Tourangeau, Couper, and Conrad (2004). One experiment varied the position of nonsubstantive response options in relation to other substantive response options and the second experiment varied the order of the response options. We implemented both experiments in an eye-tracking study. By recording respondents’ eye movements, we are able to observe how they read question stems and response options and we are able to draw conclusions about the survey response process the questions initiate. This enables us to investigate the mechanisms underlying the two interpretive heuristics and to test the assumptions of Tourangeau et al. (2004) about the ways in which interpretive heuristics influence survey responding. The eye-tracking data reveal mixed results for the two interpretive heuristics. For the middle means typical heuristic, it remains somewhat unclear whether respondents seize on the conceptual or visual midpoint of a response scale when answering survey questions. For the left and top means first heuristic, we found that violations of the heuristic increase response effort in terms of eye fixations. These results are discussed in the context of the findings of the original studies.
Mutational and Selective Processes Involved in Evolution during Bacterial Range Expansions
Authors: Bosshard Lars , Peischl Stephan , Ackermann Martin , Excoffier Laurent
Published: June 2019

Bacterial populations have been shown to accumulate deleterious mutations during spatial expansions that overall decrease their fitness and ability to grow. However, it is unclear if and how they can respond to selection in face of this mutation load. We examine here if artificial selection can counteract the negative effects of range expansions. We examined the molecular evolution of 20 mutator lines selected for fast expansions (SEL) and compared them to 20 other mutator lines freely expanding without artificial selection (CONTROL). We find that the colony size of all 20 SEL lines have increased relative to the ancestral lines, unlike CONTROL lines, showing that enough beneficial mutations are produced during spatial expansions to counteract the negative effect of expansion load. Importantly, SEL and CONTROL lines have similar numbers of mutations indicating that they evolved for the same number of generations and that increased fitness is not due to a purging of deleterious mutations. We find that loss of function mutations better explain the increased colony size of SEL lines than nonsynonymous mutations or a combination of the two. Interestingly, most loss of function mutations are found in simple sequence repeats (SSRs) located in genes involved in gene regulation and gene expression. We postulate that such potentially reversible mutations could play a major role in the rapid adaptation of bacteria to changing environmental conditions by shutting down expensive genes and adjusting gene expression.
Human activities aggravate nitrogen-deposition pollution to inland water over China
Authors: Gao Yang , Zhou Feng , Ciais Philippe , Miao Chiyuan , Yang Tao , Jia Yanlong , Zhou Xudong , Klaus Butterbach-Bahl , Yang Tiantian , Yu Guirui
Published: June 2019

In the past three decades, China has built more than 87 000 dams with a storage capacity of ≈6560 km3 and the total surface area of inland water has increased by 6672 km2. Leaching of N from fertilized soils to rivers is the main source of N pollution in China, but the exposure of a growing inland water area to direct atmospheric N deposition and N leaching caused by N deposition on the terrestrial ecosystem, together with increased N deposition and decreased N flow, also tends to raise N concentrations in most inland waters. The contribution of this previously ignored source of  N deposition to freshwaters is estimated in this study, as well as mitigation strategies. The results show that the annual amounts of N depositions ranged from 4.9 to 16.6 kg · ha−1 · yr−1 in the 1990s to exceeding 20 kg · ha−1 · yr−1 in the 2010s over most of regions in China, so the total mass of ΔN (the net contribution of N deposition to the increase in N concentration) for lakes, rivers and reservoirs change from 122.26 Gg N · yr−1 in the 1990s to 237.75 Gg N · yr−1 in the 2010s. It is suggested that reducing the N deposition from various sources, shortening the water-retention time in dams and decreasing the degree of regulation for rivers are three main measures for preventing a continuous increase in the N-deposition pollution to inland water in China.
Solar-wind–magnetosphere energy influences the interannual variability of the northern-hemispheric winter climate
Authors: He Shengping , Wang Huijun , Li Fei , Li Hui , Wang Chi
Published: June 2019

Solar irradiance has been universally acknowledged to be dominant by quasi-decadal variability, which has been adopted frequently to investigate its effect on climate decadal variability. As one major terrestrial energy source, solar-wind energy flux into Earth's magnetosphere (Ein) exhibits dramatic interannual variation, the effect of which on Earth's climate, however, has not drawn much attention. Based on the Ein estimated by 3D magnetohydrodynamic simulations, we demonstrate a novelty that the annual mean Ein can explain up to 25% total interannual variance of the northern-hemispheric temperature in the subsequent boreal winter. The concurrent anomalous atmospheric circulation resembles the positive phase of Arctic Oscillation/North Atlantic Oscillation. The warm anomalies in the tropic stratopause and tropopause induced by increased solar-wind–magnetosphere energy persist into the subsequent winter. Due to the dominant change in the polar vortex and mid-latitude westerly in boreal winter, a ‘top-down’ propagation of the stationary planetary wave emerges in the Northern Hemisphere and further influences the atmospheric circulation and climate.
Suzaku observation of Jupiter’s X-rays around solar maximum
Authors: Numazawa Masaki , Ezoe Yuichiro , Ishikawa Kumi , Ohashi Takaya , Miyoshi Yoshizumi , Kimura Tomoki , Uchiyama Yasunobu , Shiota Daikou , Branduardi-Raymont Graziella
Published: June 2019

We report on results of imaging and spectral studies of X-ray emission from Jupiter observed by Suzaku. In 2006, Suzaku found diffuse X-ray emission in 1–5 keV associated with Jovian inner radiation belts. It has been suggested that the emission is caused by the inverse-Compton scattering by ultra-relativistic electrons (∼50 MeV) in Jupiter’s magnetosphere. To confirm the existence of this emission and to understand its relation to the solar activity, we conducted an additional Suzaku observation in 2014 around the maximum of the 24th solar cycle. As a result, we successfully found the diffuse emission around Jupiter in 1–5 keV again, and also found point-like emission in 0.4–1 keV. The luminosity of the point-like emission, which was probably composed of solar X-ray scattering, charge exchange, or auroral bremsstrahlung emission, increased by a factor of ∼5 with respect to the findings from 2006, most likely due to an increase of the solar activity. The diffuse emission spectrum in the 1–5 keV band was well-fitted with a flat power-law function (Γ = 1.4 ± 0.1) as in the past observation, which supported the inverse-Compton scattering hypothesis. However, its spatial distribution changed from ∼12 × 4 Jovian radius (Rj) to ∼20 × 7 Rj. The luminosity of the diffuse emission increased by the smaller factor of ∼3. This indicates that the diffuse emission is not simply responding to the solar activity, which is also known to cause little effect on the distribution of high-energy electrons around Jupiter. Further sensitive study of the spatial and spectral distributions of the diffuse hard X-ray emission is important to understand how high-energy particles are accelerated in Jupiter’s magnetosphere.
Sensitive to Proton Rhizotoxicity1 Regulates Salt and Drought Tolerance of Arabidopsis thaliana through Transcriptional Regulation of CIPK23
Authors: Sadhukhan Ayan , Enomoto Takuo , Kobayashi Yuriko , Watanabe Toshihiro , Iuchi Satoshi , Kobayashi Masatomo , Sahoo Lingaraj , Yamamoto Yoshiharu Y , Koyama Hiroyuki
Published: June 2019

The transcription factor sensitive to proton rhizotoxicity 1 (STOP1) regulates multiple stress tolerances. In this study, we confirmed its involvement in NaCl and drought tolerance. The root growth of the T-DNA insertion mutant of STOP1 (stop1) was sensitive to NaCl-containing solidified MS media. Transcriptome analysis of stop1 under NaCl stress revealed that STOP1 regulates several genes related to salt tolerance, including CIPK23. Among all available homozygous T-DNA insertion mutants of the genes suppressed in stop1, only cipk23 showed a NaCl-sensitive root growth phenotype comparable to stop1. The CIPK23 promoter had a functional STOP1-binding site, suggesting a strong CIPK23 suppression led to NaCl sensitivity of stop1. This possibility was supported by in planta complementation of CIPK23 in the stop1 background, which rescued the short root phenotype under NaCl. Both stop1 and cipk23 exhibited a drought tolerant phenotype and increased abscisic acid-regulated stomatal closure, while the complementation of CIPK23 in stop1 reversed these traits. Our findings uncover additional pleiotropic roles of STOP1 mediated by CIPK23, which regulates various ion transporters including those regulating K+-homeostasis, which may induce a trade-off between drought tolerance and other traits.
Ethylene Inhibits Methyl Jasmonate-Induced Stomatal Closure by Modulating Guard Cell Slow-Type Anion Channel Activity via the OPEN STOMATA 1/SnRK2.6 Kinase-Independent Pathway in Arabidopsis
Authors: Munemasa Shintaro , Hirao Yukari , Tanami Kasumi , Mimata Yoshiharu , Nakamura Yoshimasa , Murata Yoshiyuki
Published: June 2019

Signal crosstalk between jasmonate and ethylene is crucial for a proper maintenance of defense responses and development. Although previous studies reported that both jasmonate and ethylene also function as modulators of stomatal movements, the signal crosstalk mechanism in stomatal guard cells remains unclear. Here, we show that the ethylene signaling inhibits jasmonate signaling as well as abscisic acid (ABA) signaling in guard cells of Arabidopsis thaliana and reveal the signaling crosstalk mechanism. Both an ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) and an ethylene-releasing compound ethephon induced transient stomatal closure, and also inhibited methyl jasmonate (MeJA)-induced stomatal closure as well as ABA-induced stomatal closure. The ethylene inhibition of MeJA-induced stomatal closure was abolished in the ethylene-insensitive mutant etr1–1, whereas MeJA-induced stomatal closure was impaired in the ethylene-overproducing mutant eto1–1. Pretreatment with ACC inhibited MeJA-induced reactive oxygen species (ROS) production as well as ABA-induced ROS production in guard cells but did not suppress ABA activation of OPEN STOMATA 1 (OST1) kinase in guard cell-enriched epidermal peels. The whole-cell patch-clamp analysis revealed that ACC attenuated MeJA and ABA activation of S-type anion channels in guard cell protoplasts. However, MeJA and ABA inhibitions of Kin channels were not affected by ACC pretreatment. These results suggest that ethylene signaling inhibits MeJA signaling and ABA signaling by targeting S-type anion channels and ROS but not OST1 kinase and K+ channels in Arabidopsis guard cells.
How can we achieve impact from public health research? A meta-ethnography of case studies
Authors: Gentry S V , Milden L , Kelly M P
Published: June 2019

Background

Generation of public health impact from research is challenging. Research of similar quality often has differential uptake and there is considerable lag time between initiation and uptake of research. Improving understanding of how research impact can be achieved may identify areas stakeholders could target.

Methods

This work uses meta-ethnography to synthesize 21 case studies exploring how researchers have generated public health policy impact.

Results

Eight constructs were identified: expertise; motivation; practical solutions to important problems; support structure and funding; collaboration; wide dissemination and use of media to contribute ideas to the wider narrative; understanding the policy realm; and models of impact. The constructs were combined in a lines-of-argument synthesis, producing a model that seeks to illustrate the diffuse, complex and dynamic nature of the process of generating impact from research.

Conclusion

Achieving research impact involves seeking to shape wider debates, building relationships with policy makers, becoming a trusted collaborator and being available to provide relevant and practical solutions to questions of concern to policy makers at the appropriate time.
Modified Babenko’s Equation For Periodic Gravity Waves On Water Of Finite Depth
Authors: Dinvay E , Kuznetsov N
Published: June 2019

A new operator equation for periodic gravity waves on water of finite depth is derived and investigated; it is equivalent to Babenko’s equation considered in Kuznetsov and Dinvay (Water Waves, 1, 2019). Both operators in the proposed equation are nonlinear and depend on the parameter equal to the mean depth of water, whereas each solution defines a parametric representation for a symmetric free surface profile. The latter is a component of a solution of the two-dimensional, nonlinear problem describing steady waves propagating in the absence of surface tension. Bifurcation curves (including a branching one) are obtained numerically for solutions of the new equation; they are compared with known results.
Health-related quality of life in systemic sclerosis before and after autologous haematopoietic stem cell transplant—a systematic review
Authors: Puyade Mathieu , Maltez Nancy , Lansiaux Pauline , Pugnet Grégory , Roblot Pascal , Colmegna Ines , Hudson Marie , Farge Dominique
Published: June 2019

Objectives

In severe rapidly progressive SSc, autologous haematopoietic stem cell transplantation (AHSCT) allows significant improvements in overall and event-free survival. We undertook this study to identify, appraise and synthesize the evidence on health-related quality of life (HRQoL) before and after AHSCT for SSc.

Methods

We performed a systematic review of the literature, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed and ScienceDirect from database inception to 1 February 2019. All articles with original HRQoL data were selected.

Results

The search identified 1080 articles, of which 8 were selected: 3 unblinded randomized controlled trials [American Scleroderma Stem Cell versus Immune Suppression Trial (ASSIST), Autologous Stem Cell Transplantation International Scleroderma, Scleroderma: Cyclophosphamide or Transplantation), 3 uncontrolled phase I or II trials and 2 cohort studies. HRQoL data from 289 SSc patients treated with AHSCT and 125 treated with intravenous CYC as a comparator with median 1.25–4.5 years follow-up were included. HRQoL was evaluated with the HAQ Disability Index (HAQ-DI; 275 patients), the 36-item Short Form Health Survey (SF-36; 249 patients) and the European Quality of Life 5-Dimensions questionnaire (EQ-5D; 138 patients). The quality of the studies was moderate to low. AHSCT was associated with significant improvement in the HAQ-DI (P = 0.02–<0.001), SF-36 Physical Component Summary score (P = 0.02–<0.0001) and EQ-5D index-based utility score (P < 0.001). The SF-36 Mental Component Summary score improved in the ASSIST (n = 19) and one small retrospective cohort (n = 30 patients, P = 0.005) but did not improve significantly in 2 randomized controlled trials (n = 200 patients, P = 0.1–0.91).

Conclusion

AHSCT in severe SSc patients is associated with significant and durable improvement in physical HRQoL.
Individual differences in resting-state connectivity and giving social support: implications for health
Authors: Inagaki Tristen K , Meyer Meghan L
Published: June 2019

There is a growing appreciation for the health benefits of giving support, though variability in such behavior exists. Based on the possibility that the dorsomedial (DMPFC) default network subsystem is associated with social thinking and behavior, integrity of this subsystem may facilitate giving support to others. The current study tested associations between DMPFC subsystem connectivity at rest and tendencies related to giving support. During a functional magnetic resonance imaging session, 45 participants completed an emotional social cues task, a resting-state scan and self-report measures of social support. Supportive behavior during the month following the scan was also assessed. Greater DMPFC subsystem connectivity at rest was associated with greater support giving (though not receiving or perceiving support) at the time of the scan and one month later. Results held after adjusting for extraversion. In addition, greater resting-state DMPFC subsystem connectivity was associated with attenuated dorsal anterior cingulate cortex, anterior insula and amygdala activity to others’ negative emotional social cues, suggesting that DMPFC subsystem integrity at rest is also associated with the dampened withdrawal response proposed to facilitate care for others in need. Together, results begin to hint at an additional role for the ‘default’ social brain: giving support to others.
TaXa21, a Leucine-Rich Repeat Receptor–Like Kinase Gene Associated with TaWRKY76 and TaWRKY62, Plays Positive Roles in Wheat High-Temperature Seedling Plant Resistance to Puccinia striiformis f. sp. tritici
Authors: Wang Jiahui , Wang Junjuan , Shang Hongsheng , Chen Xianming , Xu Xiangming , Hu Xiaoping
Published: June 2019

Puccinia striiformis f. sp. tritici causes wheat stripe rust, one of most important diseases of wheat worldwide. High-temperature seedling plant (HTSP) resistance of wheat to P. striiformis f. sp. tritici is one specific type of host resistance, induced by high temperature (HT). Receptor-like kinases (RLKs) play key roles in regulating plant development and signaling networks, but there have been no reports on possible roles played by RLKs in wheat HTSP to P. striiformis f. sp. tritici. In the present study, a leucine rich repeat (LRR)-RLK gene, TaXa21, with a high homology with rice bacterial blight resistance gene Xa21, was cloned from wheat cultivar Xiaoyan 6 (XY 6). TaXa21 expression was up-regulated by the exposure to HT (20°C) for 24 h at 8 days postinoculation with P. striiformis f. sp. tritici and was induced by ethylene (ET) and hydrogen peroxide (H2O2). Knocking down TaXa21 using virus-induced gene silencing reduced HTSP resistance to P. striiformis f. sp. tritici compared with the control plants. In addition, the expression level of TaCAT in the H2O2 pathway was induced and TaACO in the ET signal pathway was reduced in the HT-treated TaXa21-silenced plants. Transient expression of TaXa21 in tobacco leaves confirmed its subcellular localization in plasma membrane, consistent with the prediction from bioinformatics analysis. The transmembrane and kinase domain of TaXa21 can interact with TaWRKY76 in the nucleus and cell membrane, which is different from the localization of Xa21 in rice. The interaction between TaWRKY76 and TaWRKY62 (positively involved in the HTSP resistance of XY 6) were observed. Together, these results indicated that TaXa21 is a RLK associated with TaWRKY76 and TaWRKY62 and functions as a positive regulator of wheat HTSP resistance to P. striiformis f. sp. tritici. Furthermore, the host defense is mediated by the H2O2 and ET signal pathways.
Psychological First Aid
Authors: Giarratano Gloria , Bernard Marirose L. , Orlando Susan
Published: June 2019

The psychosocial needs of childbearing families drastically change after a disaster. Perinatal nurses providing postdisaster maternal-newborn care at community shelters, field hospitals, or acute care facilities must be prepared as “first responders” to address the immediate psychological distress and social needs of women and families in the first few chaotic days or weeks. The purpose of this article is to demonstrate ways nurses can integrate psychosocial and interpersonal interventions in perinatal disaster care using the framework of Psychological First Aid (PFA) developed by a team of mental health experts, along with The National Child Traumatic Stress Network and the United States (US) National Center for posttraumatic stress disorder (PTSD). The PFA framework offers evidence-informed stepwise approaches nurses can employ within their scope of practice aimed at reducing disaster survivors' initial distress and to promote short- and long-term adaptive functioning. Purposive interactions are suggested to provide emotional support, empathy, and guidance to reduce stress, restore coping skills, and help families use their strengths to begin the recovery process. Nurse leaders engaged in hospital disaster planning need to ensure that essential resources and community networks are available to provide mental health and psychosocial support for childbearing women and families in a postdisaster environment.
Development and validation of a clinical risk calculator for mortality after colectomy for fulminant Clostridium difficile colitis
Authors: Abou Khalil Maria , Bhatnagar Sahir Rai , Feldman Liane , Longtin Yves , Vasilevsky Carol-Ann , Carignan Alex , Morin Nancy , Boutros Marylise
Published: June 2019

BACKGROUND

Clostridium difficile colitis is an increasingly important cause of morbidity and mortality. Fulminant C. difficile colitis (FCDC) is a severe form of the colitis driven by a significant systemic inflammatory response, and managed with a total abdominal colectomy. Despite surgery, postoperative mortality rates remain high. The aim of this study was to develop a bedside calculator to predict the risk of 30-day postoperative mortality for patients with FCDC.

METHODS

After institutional review board approval, the American College of Surgeons National Surgical Quality Improvement Program database (2005–2015) was used to include adult patients who underwent emergency surgery for FCDC. A priori preoperative predictors of mortality were selected from the literature: age, immunosuppression, preoperative shock, intubation, and laboratory values. The predictive accuracy of different logistic regression models was measured by calculating the area under the receiver-operating characteristic curve. A cohort of 124 patients from Québec was used to validate the developed mortality calculator.

RESULTS

A total of 557 patients met the inclusion criteria, and the overall mortality was 44%. After developing the calculator, no statistically significant differences were found in comparison with the American College of Surgeons National Surgical Quality Improvement Program probability of mortality available in the database (area under the receiver operating curve, 75.61 vs. 75.14; p = 0.79). External validation with the cohort of patients from Quebec showed an area under the curve of 74.0% (95% confidence interval, 65.0–82.9).

CONCLUSION

A clinically applicable calculator using preoperative variables to predict postoperative mortality for patients with FCDC was developed and externally validated. This calculator may help guide preoperative decision making.

LEVEL OF EVIDENCE

Prognostic and epidemiological study, level III.