bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential Responses of Plasma Adropin Concentrations To Dietary Glucose or Fructose Consumption In Humans
Authors: Butler Andrew A. , St-Onge Marie-Pierre , Siebert Emily A. , Medici Valentina , Stanhope Kimber L. , Havel Peter J.
Published: October 2015

Adropin is a peptide hormone encoded by the Energy Homeostasis Associated (ENHO) gene whose physiological role in humans remains incompletely defined. Here we investigated the impact of dietary interventions that affect systemic glucose and lipid metabolism on plasma adropin concentrations in humans. Consumption of glucose or fructose as 25% of daily energy requirements (E) differentially affected plasma adropin concentrations (P < 0.005) irrespective of duration, sex or age. Glucose consumption reduced plasma adropin from 3.55 ± 0.26 to 3.28 ± 0.23 ng/ml (N = 42). Fructose consumption increased plasma adropin from 3.63 ± 0.29 to 3.93 ± 0.34 ng/ml (N = 45). Consumption of high fructose corn syrup (HFCS) as 25% E had no effect (3.43 ± 0.32 versus 3.39 ± 0.24 ng/ml, N = 26). Overall, the effect of glucose, HFCS and fructose on circulating adropin concentrations were similar to those observed on postprandial plasma triglyceride concentrations. Furthermore, increases in plasma adropin levels with fructose intake were most robust in individuals exhibiting hypertriglyceridemia. Individuals with low plasma adropin concentrations also exhibited rapid increases in plasma levels following consumption of breakfasts supplemented with lipids. These are the first results linking plasma adropin levels with dietary sugar intake in humans, with the impact of fructose consumption linked to systemic triglyceride metabolism. In addition, dietary fat intake may also increase circulating adropin concentrations.
A new tool for long-term studies of POM-bacteria interactions: overcoming the century-old Bottle Effect
Authors: Ionescu Danny , Bizic-Ionescu Mina , Khalili Arzhang , Malekmohammadi Reza , Morad Mohammad Reza , de Beer Dirk , Grossart Hans-Peter
Published: October 2015

Downward fluxes of particulate organic matter (POM) are the major process for sequestering atmospheric CO2 into aquatic sediments for thousands of years. Budget calculations of the biological carbon pump are heavily based on the ratio between carbon export (sedimentation) and remineralization (release to the atmosphere). Current methodologies determine microbial dynamics on POM using closed vessels, which are strongly biased towards heterotrophy due to rapidly changing water chemistry (Bottle Effect). We developed a flow-through rolling tank for long term studies that continuously maintains POM at near in-situ conditions. There, bacterial communities resembled in-situ communities and greatly differed from those in the closed systems. The active particle-associated community in the flow-through system was stable for days, contrary to hours previously reported for closed incubations. In contrast to enhanced respiration rates, the decrease in photosynthetic rates on particles throughout the incubation was much slower in our system than in traditional ones. These results call for reevaluating experimentally-derived carbon fluxes estimated using traditional methods.
Smart gating membranes with in situ self-assembled responsive nanogels as functional gates
Authors: Luo Feng , Xie Rui , Liu Zhuang , Ju Xiao-Jie , Wang Wei , Lin Shuo , Chu Liang-Yin
Published: October 2015

Smart gating membranes, inspired by the gating function of ion channels across cell membranes, are artificial membranes composed of non-responsive porous membrane substrates and responsive gates in the membrane pores that are able to dramatically regulate the trans-membrane transport of substances in response to environmental stimuli. Easy fabrication, high flux, significant response and strong mechanical strength are critical for the versatility of such smart gating membranes. Here we show a novel and simple strategy for one-step fabrication of smart gating membranes with three-dimensionally interconnected networks of functional gates, by self-assembling responsive nanogels on membrane pore surfaces in situ during a vapor-induced phase separation process for membrane formation. The smart gating membranes with in situ self-assembled responsive nanogels as functional gates show large flux, significant response and excellent mechanical property simultaneously. Because of the easy fabrication method as well as the concurrent enhancement of flux, response and mechanical property, the proposed smart gating membranes will expand the scope of membrane applications and provide ever better performances in their applications.
Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway
Authors: Ni Qubo , Tan Yang , Zhang Xianrong , Luo Hanwen , Deng Yu , Magdalou Jacques , Chen Liaobin , Wang Hui
Published: October 2015

Epidemiological evidence indicates that osteoarthritis (OA) and prenatal ethanol exposure (PEE) are both associated with low birth weight but possible causal interrelationships have not been investigated. To investigate the effects of PEE on the susceptibility to OA in adult rats that experienced intrauterine growth retardation (IUGR) and to explore potential intrauterine mechanisms, we established the rat model of IUGR by PEE and dexamethasone and the female fetus and 24-week-old adult offspring subjected to strenuous running for 6 weeks were sacrificed. Knee joints were collected from fetuses and adult offspring for histochemistry, immunohistochemistry and qPCR assays. Histological analyses and the Mankin score revealed increased cartilage destruction and accelerated OA progression in adult offspring from the PEE group compared to the control group. Immunohistochemistry showed reduced expression of insulin-like growth factor-1 (IGF-1) signaling pathway components. Furthermore, fetuses in the PEE group experienced IUGR but exhibited a higher postnatal growth rate. The expression of many IGF-1 signaling components was downregulated, which coincided with reduced amounts of type II collagen in the epiphyseal cartilage of fetuses in the PEE group. These results suggest that PEE enhances the susceptibility to OA in female adult rat offspring by down-regulating IGF-1 signaling and retarding articular cartilage development.
Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1
Authors: Qian Xuli , Qin Luyang , Xing Guangqian , Cao Xin
Published: October 2015

Wolfram syndrome (WS) is a rare, progressive, neurodegenerative disorder that has an autosomal recessive pattern of inheritance. The gene for WS, wolfram syndrome 1 gene (WFS1), is located on human chromosome 4p16.1 and encodes a transmembrane protein. To date, approximately 230 mutations in WFS1 have been confirmed, in which nonsynonymous single nucleotide polymorphisms (nsSNPs) are the most common forms of genetic variation. Nonetheless, there is poor knowledge on the relationship between SNP genotype and phenotype in other nsSNPs of the WFS1 gene. Here, we analysed 395 nsSNPs associated with the WFS1 gene using different computational methods and identified 20 nsSNPs to be potentially pathogenic. Furthermore, to identify the amino acid distributions and significances of pathogenic nsSNPs in the protein of WFS1, its transmembrane domain was constructed by the TMHMM server, which suggested that mutations outside of the TMhelix could have more effects on protein function. The predicted pathogenic mutations for the nsSNPs of the WFS1 gene provide an excellent guide for screening pathogenic mutations.
Expansion dynamics in a one-dimensional hard-core boson model with three-body interactions
Authors: Ren Jie , Wu Yin-Zhong , Xu Xue-Fen
Published: October 2015

Using the adaptive time-dependent density matrix renormalization group method, we numerically investigate the expansion dynamics of bosons in a one-dimensional hard-core boson model with three-body interactions. It is found that the bosons expand ballistically with weak interaction, which are obtained by local density and the radius Rn. It is shown that the expansion velocity V, obtained from Rn = Vt, is dependent on the number of bosons. As a prominent result, the expansion velocity decreases with the enhancement of three-body interaction. We further study the dynamics of the system, which quenches from the ground state with two-thirds filling, the results indicate the expansion is also ballistic in the gapless phase regime. It could help us detect the phase transition in the system.
Transcranial magnetic stimulation facilitates neurorehabilitation after pediatric traumatic brain injury
Authors: Lu Hongyang , Kobilo Tali , Robertson Courtney , Tong Shanbao , Celnik Pablo , Pelled Galit
Published: October 2015

Traumatic brain injury (TBI) is the leading cause of death and disability among children in the United States. Affected children will often suffer from emotional, cognitive and neurological impairments throughout life. In the controlled cortical impact (CCI) animal model of pediatric TBI (postnatal day 16–17) it was demonstrated that injury results in abnormal neuronal hypoactivity in the non-injured primary somatosensory cortex (S1). It materializes that reshaping the abnormal post-injury neuronal activity may provide a suitable strategy to augment rehabilitation. We tested whether high-frequency, non-invasive transcranial magnetic stimulation (TMS) delivered twice a week over a four-week period can rescue the neuronal activity and improve the long-term functional neurophysiological and behavioral outcome in the pediatric CCI model. The results show that TBI rats subjected to TMS therapy showed significant increases in the evoked-fMRI cortical responses (189%), evoked synaptic activity (46%), evoked neuronal firing (200%) and increases expression of cellular markers of neuroplasticity in the non-injured S1 compared to TBI rats that did not receive therapy. Notably, these rats showed less hyperactivity in behavioral tests. These results implicate TMS as a promising approach for reversing the adverse neuronal mechanisms activated post-TBI. Importantly, this intervention could readily be translated to human studies.
Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function
Authors: Chen Gin-Fu , Sudhahar Varadarajan , Youn Seock-Won , Das Archita , Cho Jaehyung , Kamiya Tetsuro , Urao Norifumi , McKinney Ronald D. , Surenkhuu Bayasgalan , Hamakubo Takao , Iwanari Hiroko , Li Senlin , Christman John W. , Shantikumar Saran , Angelini Gianni D. , Emanueli Costanza , Ushio-Fukai Masuko , Fukai Tohru
Published: October 2015

Copper (Cu), an essential micronutrient, plays a fundamental role in inflammation and angiogenesis; however, its precise mechanism remains undefined. Here we uncover a novel role of Cu transport protein Antioxidant-1 (Atox1), which is originally appreciated as a Cu chaperone and recently discovered as a Cu-dependent transcription factor, in inflammatory neovascularization. Atox1 expression is upregulated in patients and mice with critical limb ischemia. Atox1-deficient mice show impaired limb perfusion recovery with reduced arteriogenesis, angiogenesis and recruitment of inflammatory cells. In vivo intravital microscopy, bone marrow reconstitution and Atox1 gene transfer in Atox1−/− mice show that Atox1 in endothelial cells (ECs) is essential for neovascularization and recruitment of inflammatory cells which release VEGF and TNFα. Mechanistically, Atox1-depleted ECs demonstrate that Cu chaperone function of Atox1 mediated through Cu transporter ATP7A is required for VEGF-induced angiogenesis via activation of Cu enzyme lysyl oxidase. Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFκB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFα in an ATP7A-independent manner. These findings demonstrate a novel linkage between Atox1 and NADPH oxidase involved in inflammatory neovascularization and suggest Atox1 as a potential therapeutic target for treatment of ischemic disease.
Understanding Cooperative Behavior Based on the Coevolution of Game Strategy and Link Weight
Authors: Huang Keke , Zheng Xiaoping , Li Zhijie , Yang Yeqing
Published: October 2015

In reality, the dependency relationship among individuals is heterogeneous and time-varying. Based on this fact, we present a new mechanism of coevolution of game strategy and link weight when analyzing the evolution of cooperation. In detail, we model the population on a regular network, on which the relationship between players is depicted by a weighted link and prisoner’s dilemma has been applied to describe the interaction of players. Further, the impact of this mechanism on the cooperative behavior has been outlined. By conducting large-scale Monte Carlo simulations, we can easily draw a conclusion that this mechanism can promote cooperation efficiently. Compared with the traditional case, when the temptation of defectionbis large, the fraction of cooperation is still able to keep in a high level. With a comprehensive examination of the distribution of stable link weight, it is evident that the coevolution mechanism would deviate the initial distribution. This mechanism induces the heterogeneity of players, which enhances the fraction of cooperation. Numerical simulations also indicate that an intermediate value of Δ/δ warrants an optimal resolution of prisoner’s dilemma. The mechanism of coevolution of game strategy and link weight has a practical significance and will provide new insight for the further research.
On the correlation between microscopic structural heterogeneity and embrittlement behavior in metallic glasses
Authors: Li Weidong , Gao Yanfei , Bei Hongbin
Published: October 2015

In order to establish a relationship between microstructure and mechanical properties, we systematically annealed a Zr-based bulk metallic glass (BMG) at 100 ~ 300 °C and measured their mechanical and thermal properties. The as-cast BMG exhibits some ductility, while the increase of annealing temperature and time leads to the transition to a brittle behavior that can reach nearly-zero fracture energy. The differential scanning calorimetry did not find any significant changes in crystallization temperature and enthalpy, indicating that the materials still remained fully amorphous. Elastic constants measured by ultrasonic technique vary only slightly with respect to annealing temperature and time, which does obey the empirical relationship between Poisson’s ratio and fracture behavior. Nanoindentation pop-in tests were conducted, from which the pop-in strength mapping provides a “mechanical probe” of the microscopic structural heterogeneities in these metallic glasses. Based on stochastically statistic defect model, we found that the defect density decreases with increasing annealing temperature and annealing time and is exponentially related to the fracture energy. A ductile-versus-brittle behavior (DBB) model based on the structural heterogeneity is developed to identify the physical origins of the embrittlement behavior through the interactions between these defects and crack tip.
Controlled mud-crack patterning and self-organized cracking of polydimethylsiloxane elastomer surfaces
Authors: Seghir Rian , Arscott Steve
Published: October 2015

Exploiting pattern formation – such as that observed in nature – in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on elastomeric films. A thin, brittle silica-like crust is formed on the surface of polydimethylsiloxane (PDMS) using oxygen plasma. This crust is subsequently cracked via the deposition of a thin metal film – having residual tensile stress. The density of the mud-crack patterns depends on the plasma dose and on the metal thickness. The mud-crack patterning can be controlled depending on the thickness and shape of the metallization – ultimately leading to regularly spaced cracks and/or metal mesa structures. Such patterning of the cracks indicates a level of self-organization in the structuring and layout of the features – arrived at simply by imposing metallization boundaries in proximity to each other, separated by a distance of the order of the critical dimension of the pattern size apparent in the large surface mud-crack patterns.
Microfluidic White Organic Light-Emitting Diode Based on Integrated Patterns of Greenish-Blue and Yellow Solvent-Free Liquid Emitters
Authors: Kobayashi Naofumi , Kasahara Takashi , Edura Tomohiko , Oshima Juro , Ishimatsu Ryoichi , Tsuwaki Miho , Imato Toshihiko , Shoji Shuichi , Mizuno Jun
Published: October 2015

We demonstrated a novel microfluidic white organic light-emitting diode (microfluidic WOLED) based on integrated sub-100-μm-wide microchannels. Single-μm-thick SU-8-based microchannels, which were sandwiched between indium tin oxide (ITO) anode and cathode pairs, were fabricated by photolithography and heterogeneous bonding technologies. 1-Pyrenebutyric acid 2-ethylhexyl ester (PLQ) was used as a solvent-free greenish-blue liquid emitter, while 2,8-di-tert-butyl-5,11-bis(4-tert-butylphenyl)-6,12-diphenyltetracene (TBRb)-doped PLQ was applied as a yellow liquid emitter. In order to form the liquid white light-emitting layer, the greenish-blue and yellow liquid emitters were alternately injected into the integrated microchannels. The fabricated electro-microfluidic device successfully exhibited white electroluminescence (EL) emission via simultaneous greenish-blue and yellow emissions under an applied voltage of 100 V. A white emission with Commission Internationale de l’Declairage (CIE) color coordinates of (0.40, 0.42) was also obtained; the emission corresponds to warm-white light. The proposed device has potential applications in subpixels of liquid-based microdisplays and for lighting.
Reaching Consensus by Allowing Moments of Indecision
Authors: Svenkeson A. , Swami A.
Published: October 2015

Group decision-making processes often turn into a drawn out and costly battle between two opposing subgroups. Using analytical arguments based on a master equation description of the opinion dynamics occurring in a three-state model of cooperatively interacting units, we show how the capability of a social group to reach consensus can be enhanced when there is an intermediate state for indecisive individuals to pass through. The time spent in the intermediate state must be relatively short compared to that of the two polar states in order to create the beneficial effect. Furthermore, the cooperation between individuals must not be too low, as the benefit to consensus is possible only when the cooperation level exceeds a specific threshold. We also discuss how zealots, agents that remain in one state forever, can affect the consensus among the rest of the population by counteracting the benefit of the intermediate state or making it virtually impossible for an opposition to form.
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
Authors: Mardinoglu Adil , Heiker John T. , Gärtner Daniel , Björnson Elias , Schön Michael R. , Flehmig Gesine , Klöting Nora , Krohn Knut , Fasshauer Mathias , Stumvoll Michael , Nielsen Jens , Blüher Matthias
Published: October 2015

Weight loss has been shown to significantly improve Adipose tissue (AT) function, however changes in AT gene expression profiles particularly in visceral AT (VAT) have not been systematically studied. Here, we tested the hypothesis that extensive weight loss in response to bariatric surgery (BS) causes AT gene expression changes, which may affect energy and lipid metabolism, inflammation and secretory function of AT. We assessed gene expression changes by whole genome expression chips in AT samples obtained from six morbidly obese individuals, who underwent a two step BS strategy with sleeve gastrectomy as initial and a Roux-en-Y gastric bypass as second step surgery after 12 ± 2 months. Global gene expression differences in VAT and subcutaneous (S)AT were analyzed through the use of genome-scale metabolic model (GEM) for adipocytes. Significantly altered gene expressions were PCR-validated in 16 individuals, which also underwent a two-step surgery intervention. We found increased expression of cell death-inducing DFFA-like effector a (CIDEA), involved in formation of lipid droplets in both fat depots in response to significant weight loss. We observed that expression of the genes associated with metabolic reactions involved in NAD+, glutathione and branched chain amino acid metabolism are significantly increased in AT depots after surgery-induced weight loss.
Detection of DNA methyltransferase activity using allosteric molecular beacons
Authors: Zhang Weiting , Zu Xiaolong , Song Yanling , Zhu Zhi , Yang Chaoyong James
Published: October 2015

Abnormal DNA methylation patterns caused by altered DNA methyltransferase (MTase) activity are closely associated with cancer. Herein, using DNA adenine methylation methyltransferase (Dam MTase) as a model analyte, we designed an allosteric molecular beacon (aMB) for sensitive detection of Dam MTase activity.
A fluorophore-conjugated ascorbic acid functions for the visualization of sodium vitamin C transporters in living cells
Authors: Yin Junfa , Song Yuanyuan , Zhang Ning , Xu Tian , Wang Hailin
Published: October 2015

We designed and synthesized a fluorophore-conjugated ascorbic acid, and found that this compound is capable of selectively visualizing the level and changes of intracellular SVCTs in living cells.
Dual acid-responsive supramolecular nanoparticles as new anticancer drug delivery systems
Authors: Wang Chunran , Chen Xiaofei , Yao Xuemei , Chen Li , Chen Xuesi
Published: October 2015

In this article, a dual acid-responsive drug delivery system has been fabricatedviasimple host–guest recognition.
Ionic liquid functionalized multi-walled carbon nanotubes/zeolitic imidazolate framework hybrid membranes for efficient H2/CO2 separation
Authors: Huang Yuyao , Xiao Yuanlong , Huang Hongliang , Liu Ziping , Liu Dahuan , Yang Qingyuan , Zhong Chongli
Published: October 2015

A ZIF-9 membrane covered by ionic liquid (IL) functionalized carbon nanotubes (CNTs) was prepared with a high selectivity for H2/CO2.
Performance enhancement of planar heterojunction perovskite solar cells by n-doping of the electron transporting layer
Authors: Kim Shin Sung , Bae Seunghwan , Jo Won Ho
Published: October 2015

Herein we report a simple n-doping method to enhance the performance of perovskite solar cells with a planar heterojunction structure.
Sensitive discrimination of stable mismatched base pairs by an abasic site modified fluorescent probe and lambda exonuclease
Authors: Wu Tongbo , Xiao Xianjin , Gu Feidan , Zhao Meiping
Published: October 2015

An abasic site modified fluorescent probe has been developed which enabled the rapid discrimination of stable single mismatched base pairs by lambda exonuclease with remarkably high discrimination factors (447 for T:G and 238 for A:G).
A stable graphite negative electrode for the lithium–sulfur battery
Authors: Jeschull Fabian , Brandell Daniel , Edström Kristina , Lacey Matthew J.
Published: October 2015

Functional binder-protected negative electrodes enable sulfur batteries with considerably improved lifetime and efficiency, and reduced self-discharge.
Suzuki-type cross coupling between aryl halides and silylboranes for the syntheses of aryl silanes
Authors: Guo Huifang , Chen Xiao , Zhao Chunliang , He Wei
Published: October 2015

A simple but efficient system with broad substrate scope was developed for the syntheses of aryl silanes.
In vivo observation of the pH alternation in mitochondria for various external stimuli
Authors: Cao Lixia , Zhao Zhensheng , Zhang Tao , Guo Xudong , Wang Shuangqing , Li Shayu , Li Yi , Yang Guoqiang
Published: October 2015

We developed a new indicator Mito-pH-1 for the ratiometric fluorescence detection of the mitochondria pH value (pHm) which has excellent tolerance to environment change. Mito-pH-1 has been firstly used to monitor the change of pHmunder temperature and H2O2stimuli in living cells.
Core–shell nanocrystallite growth via heterogeneous interface manipulation
Authors: Yang Po-Wei , Liu Yu-Ting , Hsu Shu-Ping , Wang Kuan-Wen , Jeng U-Ser , Lin Tsang-Lang , Chen Tsan-Yao
Published: October 2015

In the case of short incubation times, the Pt atoms are directly distributed atop the core crystal. For long incubation times, a PtRu alloyed layer forms prior to the deposition of the Pt shell crystal in Ru core–PtRu alloy–Pt rich shell NCs.
Remarks on energetic conditions for positronium formation in non-polar solids. Coupled dipole method application
Authors: Pietrow M.
Published: October 2015

A numerical program calculating the energy of a positron or/and an electron near the free volume in solid n-alkanes has been built.
Activating and tuning basal planes of MoO2, MoS2, and MoSe2for hydrogen evolution reaction
Authors: Lin Shi-Hsin , Kuo Jer-Lai
Published: October 2015

Inert basal planes of transition metal dichalcogenides can be activated by creating defects, resulting in better performance for hydrogen evolution reaction.
The transition metal surface passivated edges of hexagonal boron nitride (h-BN) and the mechanism of h-BN's chemical vapor deposition (CVD) growth
Authors: Zhao Ruiqi , Li Feifei , Liu Zhirong , Liu Zhongfan , Ding Feng
Published: October 2015

The kinetics of chemical vapor deposition growth of h-BN on a transition metal catalyst surface is dominated by the metal surface passivated edge structures.
New insights into the photodissociation of methyl iodide at 193 nm: stereodynamics and product branching ratios
Authors: Marggi Poullain Sonia , González Marta G. , Samartzis Peter C. , Kitsopoulos Theofanis N. , Rubio-Lago Luis , Bañares Luis
Published: October 2015

Stereodynamics imaging provides new insights into the photodissociation of methyl iodide at 193 nm.
Intrinsic twisting instability of kinked silicon nanowires for intracellular recording
Authors: Jiang Jin-Wu
Published: October 2015

External influence can actuate the intrinsic twisting vibration in the kinked silicon nanowire, in which the twisting amplitude is geometry dependent.
Can we beat the biotin–avidin pair?: cucurbit[7]uril-based ultrahigh affinity host–guest complexes and their applications
Authors: Shetty Dinesh , Khedkar Jayshree K. , Park Kyeng Min , Kim Kimoon
Published: October 2015

The latest developments of ultrahigh-affinity cucurbit[7]uril–guest complexes and their utilization in a number of challenging applications are presented.
Functionalization of Zr-based MOFs with alkyl and perfluoroalkyl groups: the effect on the water sorption behavior
Authors: Yu C. , Bourrelly S. , Martineau C. , Saidi F. , Bloch E. , Lavrard H. , Taulelle F. , Horcajada P. , Serre C. , Llewellyn P. L. , Magnier E. , Devic T.
Published: October 2015

The influence of organic functional groups (fluorinated versus non-fluorinated) on the hydrophilic/hydrophobic balance of MOFs has been studied.
The flexibility of modified-linker MIL-53 materials
Authors: Munn Alexis S. , Pillai Renjith S. , Biswas Shyam , Stock Norbert , Maurin Guillaume , Walton Richard I.
Published: October 2015

The flexibility of eight aluminium hydroxo terephthalates [Al(OH)(BDC–X)] (X = –H, –CH3, –Cl, –Br, –NH2, –NO2, –(OH)2, –CO2H) has been investigated upon thermal dehydration, superhydration and methanol adsorption/desorption using in situ powder X-ray diffraction.
Helix aspersa gelatin as an emulsifier and emulsion stabilizer: functional properties and effects on pancreatic lipolysis
Authors: Zarai Zied , Balti Rafik , Sila Assaâd , Ben Ali Yassine , Gargouri Youssef
Published: October 2015

Emulsions are widely used in food and pharmaceutical applications for the encapsulation, solubilization, entrapment, and controlled delivery of active ingredients.
Anti-steatotic effects of an n-3 LCPUFA and extra virgin olive oil mixture in the liver of mice subjected to high-fat diet
Authors: Valenzuela Rodrigo , Espinosa Alejandra , Llanos Paola , Hernandez-Rodas Maria Catalina , Barrera Cynthia , Vergara Daniela , Romero Nalda , Pérez Francisco , Ruz Manuel , Videla Luis A.
Published: October 2015

We evaluated the anti-steatotic effects of n-3 long-chain polyunsaturated fatty acids plus extra virgin olive oil in the liver of mice fed a high fat diet.
Reductive deconstruction of organosolv lignin catalyzed by zeolite supported nickel nanoparticles
Authors: Kasakov Stanislav , Shi Hui , Camaioni Donald M. , Zhao Chen , Baráth Eszter , Jentys Andreas , Lercher Johannes A.
Published: October 2015

Breaking good: In situ ATR-IR spectroscopy tracked the Ni catalyzed deconstruction and hydrodeoxygenation of organosolv lignin in n-hexadecane, towards the production of naphthenes.
Backbone circularization of Bacillus subtilis family 11 xylanase increases its thermostability and its resistance against aggregation
Authors: Waldhauer Max C. , Schmitz Silvan N. , Ahlmann-Eltze Constantin , Gleixner Jan G. , Schmelas Carolin C. , Huhn Anna G. , Bunne Charlotte , Büscher Magdalena , Horn Max , Klughammer Nils , Kreft Jakob , Schäfer Elisabeth , Bayer Philipp A. , Krämer Stephen G. , Neugebauer Julia , Wehler Pierre , Mayer Matthias P. , Eils Roland , Di Ventura Barbara
Published: October 2015

While using a serine (S) as linker for circularization increases the thermostability, a longer linker (RGKCWE) leads to reduced aggregation after heat shock at elevated temperatures.
Dynamic equilibrium of endogenous selenium nanoparticles in selenite-exposed cancer cells: a deep insight into the interaction between endogenous SeNPs and proteins
Authors: Bao Peng , Chen Song-Can , Xiao Ke-Qing
Published: October 2015

Dynamics of endogenous SeNPs in selenite-exposed cancer cells provide a strategy for designing efficient intracellular self-assembling systems for overcoming drug resistance.
Pressure-sensitive adhesive powder
Authors: Fujii S. , Sawada S. , Nakayama S. , Kappl M. , Ueno K. , Shitajima K. , Butt H.-J. , Nakamura Y.
Published: October 2015

Pressure-sensitive adhesive powder shows no adhesion in its original form and shows its adhesive nature after application of shear stress.
FTIR, magnetic and Mössbauer investigations of nano-crystalline FexCo1−x(0.4 ≤ x ≤ 0.8) alloys synthesized via a superhydride reduction route
Authors: Dalavi Shankar B. , Raja M. Manivel , Panda Rabi N.
Published: October 2015

Observation of strong dipolar interactions leading to improved magnetic properties of chemically synthesized FexCo1−xalloy nano-materials (size range, 24–51 nm).
Achieving accelerated osteogenic differentiation via novel magnesium silicate hollow spheres
Authors: Wang Baixiang , Wang Yu , Liu Chuanxia , Feng Xiaoxia , Yang Guoli , Wang Huiming
Published: October 2015

Novel MgSiO3hollow spheres have been rationally designed and applied as promising candidates for osteogenic differentiationin vitro.
Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents
Authors: Hachani Roxanne , Lowdell Mark , Birchall Martin , Hervault Aziliz , Mertz Damien , Begin-Colin Sylvie , Thanh Nguyễn Thị Kim
Published: October 2015

High pressure and high temperature conditions were used to achieve IONPs with a narrow particle size distribution and high magnetic moment. Their biocompatibility was demonstrated with human mesenchymal stem cells.
A multifunctional role of trialkylbenzenes for the preparation of aqueous colloidal mesostructured/mesoporous silica nanoparticles with controlled pore size, particle diameter, and morphology
Authors: Yamada Hironori , Ujiie Hiroto , Urata Chihiro , Yamamoto Eisuke , Yamauchi Yusuke , Kuroda Kazuyuki
Published: October 2015

A judicious choice of trialkylbenzenes is critical to control the pore size, particle diameter, and morphology of aqueous colloidal mesoporous silica nanoparticles.
2D nanosheet molybdenum disulphide (MoS2) modified electrodes explored towards the hydrogen evolution reaction
Authors: Rowley-Neale Samuel J. , Brownson Dale A. C. , Smith Graham C. , Sawtell David A. G. , Kelly Peter J. , Banks Craig E.
Published: October 2015

2D molybdenum disulphide nanosheets are explored as an electrocatalyst towards the hydrogen evolution reaction (HER) using modified carbon based electrodes.
Synthetic multivalency for biological applications
Authors: Mahon Eugene , Barboiu Mihail
Published: October 2015

Current directions and emerging possibilities under investigation for the integration of synthetic and semi-synthetic multivalent architectures with biology are discussed. Attention is focussed around multivalent interactions, their fundamental role in biology, and approaches in emulating them in terms of structure and functionality using synthetic architectures.
A concise synthesis of single components of partially sulfated oligomannans
Authors: Tony Mong Kwok-Kong , Shiau Kai-Sheng , Lin Yu Hsien , Cheng Kuang-Chun , Lin Chun-Hung
Published: October 2015

The synthesis of polysulfated α(1 → 3)/α(1 → 2)-linked oligomannans using the DMF-modulated glycosylation method is reported.
Molecular binding behaviors and thermodynamics of ferrocenyl dimethylaminium derivatives by anionic pillar[5]arene
Authors: Zhang Cui-Fang , Li Sheng-Hua , Zhang Cai-Cai , Liu Yu
Published: October 2015

A novel anionic water-soluble pillar[5]arene (4C-WP5A) was synthesized via a convenient synthetic strategy of the direct cyclization of a functionalized hydroquinone monomer.
Multi-responsive supramolecular hydrogels based on merocyanine–peptide conjugates
Authors: Wang Wei , Hu Jing , Zheng Mengmeng , Zheng Li , Wang Huan , Zhang Yan
Published: October 2015

Stimuli-responsive hydrogels are “smart” materials with diverse applications.
A thermoresponsive polymer supporter for concerted catalysis of ferrocene with a ruthenium catalyst in living radical polymerization: high activity and efficient removal of metal residues
Authors: Fujimura Kojiro , Ouchi Makoto , Sawamoto Mitsuo
Published: October 2015

A thermoresponsive polymer-supported catalyst consisting of a ruthenium (Ru) main catalyst and a ferrocene (Fc) cocatalyst was designed to realize both high activity and efficient removal of metal residues.
CO2 and ambient air in metal–oxygen batteries: steps towards reality
Authors: Xu Shaomao , Lau Sampson , Archer Lynden A.
Published: October 2015

Studies on involving CO2 and ambient air in cathode gas bring the potential of a real rechargeable high-energy metal–air battery.
An integrated flow and microwave approach to a broad spectrum protein kinase inhibitor
Authors: Russell Cecilia , Lin Andrew J. S. , Hains Peter , Simone Michela I. , Robinson Phillip J. , McCluskey Adam
Published: October 2015

The protein kinase inhibitor CTx-0152960 and the piperazinyl analogue CTx-0294885 were prepared using a hybrid flow and microwave approach.
Porous silicon nanoparticles as a nanophotocathode for photoelectrochemical water splitting
Authors: Chandrasekaran Soundarrajan , McInnes Steven J. P. , Macdonald Thomas J. , Nann Thomas , Voelcker Nicolas H.
Published: October 2015

An investigation on the nanophotocathode fabrication using electrochemically anodised pSi NPs for photoelectrochemical water splitting.
Detection of a high photoresponse at zero bias from a highly conducting ZnO:Ga based UV photodetector
Authors: Sharma Pankaj , Singh Rohit , Awasthi Vishnu , Pandey Sushil K. , Garg Vivek , Mukherjee Shaibal
Published: October 2015

Ga-doped ZnO based ultraviolet photodetectors (PDs) were fabricated with a metal–semiconductor–metal structure. The room-temperature operable PDs had 58 mA W−1 responsivity at zero bias with internal and external quantum efficiency values of ∼22.5 and 37.4%.
Thickness and substrate dependences of phase transition, drug release and antibacterial properties of PNIPAm-co-AAc films
Authors: Elashnikov R. , Radocha M. , Rimpelova S. , Švorčík V. , Lyutakov O.
Published: October 2015

Normalized absorption coefficient at 590 nm of solutions of extracted CV from 50 nm and 500 nm thick PNIPAm-co-AAc films deposited on Au substrates. Releases were measured for temperatures below (25 °C) and above (40 °C) the LCST.
Ultrafast electrochemical preparation of graphene/CoS nanosheet counter electrodes for efficient dye-sensitized solar cells
Authors: Zhu Chongyang , Min Huihua , Xu Feng , Chen Jing , Dong Hui , Tong Ling , Zhu Yimei , Sun Litao
Published: October 2015

Utilizing inexpensive, high-efficiency counter electrodes (CEs) to replace the traditional platinum counterparts in dye-sensitized solar cells (DSSCs) is worthwhile.
Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus
Authors: Bhakat Soumendranath , Delang Leen , Kaptein Suzanne , Neyts Johan , Leyssen Pieter , Jayaprakash Venkatesan
Published: October 2015

Re-purposing HIV/HCV inhibitors against DENV and CHIKV using computer aided drug design.
Carbon nanotube-based QuEChERS extraction and enhanced product ion scan-assisted confirmation of multi-pesticide residue in dried tangerine peel
Authors: Dou Xiaowen , Chu Xianfeng , Kong Weijun , Yang Yinhui , Yang Meihua
Published: October 2015

Carbon nanotubes-based QuEChERS extraction and enhanced product ion scan-assisted confirmation was developed for multi-pesticide residue analysis in dried tangerine peels.
Bioreceptor multi-walled carbon nanotubes@Fe3O4@SiO2–surface molecular imprinted polymer in an ultrasensitive chemiluminescent biosensor for bovine hemoglobin
Authors: Duan Huimin , Wang Xiaojiao , Wang Yanhui , Li Jianbo , Luo Chuannan
Published: October 2015

A highly selective and ultrasensitive chemiluminescent biosensor, based on a bioreceptor surface molecular imprinted polymer using core–shell Fe3O4@SiO2–multi-walled carbon nanotube nanostructures as the backbone material, for bovine hemoglobin (BHb) detection was proposed.
Synthesis of amphiphilic fluorescent PEGylated AIE nanoparticles via RAFT polymerization and their cell imaging applications
Authors: Huang Zengfang , Zhang Xiqi , Zhang Xiaoyong , Wang Shiqi , Yang Bin , Wang Ke , Yuan Jinying , Tao Lei , Wei Yen
Published: October 2015

This work reports the fabrication of amphiphilic TPEV–PEG fluorescent copolymers via RAFT polymerization of polymerizable AIE and PEGMA with promising applications for bioimaging.
Nimbolide from Azadirachta indica and its derivatives plus first-generation cephalosporin antibiotics: a novel drug combination for wound-infecting pathogens
Authors: Dhanya S. R. , Kumar S. Nishanth , Sankar Vandana , Raghu K. G. , Kumar B. S. Dileep , Nair Mangalam S.
Published: October 2015

We evaluate the in vitro efficacy of nimbolide, desacetylnimbin, and the amide derivatives of nimbolide in combination with first-generation cephalosporin antibiotics against major wound-associated bacterial pathogens.
Multifunctional polymers with biomimetic compound architectures via nanoporous AAO films for efficient solar energy harvesting in dye-sensitized solar cells
Authors: Dudem Bhaskar , Leem Jung Woo , Lim Joo Ho , Lee Soo Hyun , Yu Jae Su
Published: October 2015

Polydimethylsiloxane with a biomimetic compound architecture consisting of hierarchical nanobumps/microcone arrays as a protective cover-layer for DSSCs improves solar power conversion efficiency.
Significance enhancement in the conductivity of core shell nanocomposite electrolytes
Authors: Rafique Asia , Raza Rizwan , Akram Nadeem , Kaleem Ullah M. , Ali Amjad , Irshad Muneeb , Siraj Khurram , Khan M. Ajmal , Zhu Bin , Dawson Richard
Published: October 2015

The co-doped-carbonate composite electrolyte (core shell) gives promise in addressing the challenge to lower the operating temperature of SOFCs.
Creating surface patterns of polymer brushes by degrafting via tetrabutyl ammonium fluoride
Authors: Patil Rohan , Kiserow Douglas , Genzer Jan
Published: October 2015

We demonstrate the use of tetrabutyl ammonium fluoride (TBAF) for creating spatial patterns of poly(methyl methacrylate) (PMMA) brushes on a flat silica support by degrafting PMMA grafted chains from selected regions on the substrate.
Molten salt assisted synthesis of black titania hexagonal nanosheets with tuneable phase composition and morphology
Authors: Xu Jijian , Zhu Guilian , Lin Tianquan , Hong Zhanglian , Wang Juan , Huang Fuqiang
Published: October 2015

A facile high yield molten salt route to fabricate black titania hexagonal nanosheets under atmospheric pressure and low temperature.
Low hazard small-scale synthesis and chemical analysis of high purity nitroglycerine (NG)
Authors: Contini Alessandro E. , Flood Nathan , McAteer Daniel , Mai Nathalie , Akhavan Jacqueline
Published: October 2015

A two-phase batch method to prepare high purity 1,2,3-propanetriyl trinitrate (nitroglycerine, NG) was evaluated, simplified and adapted specifically for low hazard small-scale synthesis.
Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles
Authors: Querard Pierre , Girard Simon A. , Uhlig Nick , Li Chao-Jun
Published: October 2015

We report the first cationic gold(i)-catalyzed one-pot reaction of amide, aldehyde and alkyne followed by cyclization, to successfully access highly substituted oxazoles derivatives in good yields.
Concise synthesis of (+)-fastigiatine
Authors: Samame Renzo A. , Owens Christina M. , Rychnovsky Scott D.
Published: October 2015

Biomimetic transannular Mannich cyclization led to (+)-fastigiatine.
Surface chemistry of La0.6Sr0.4CoO3−δ thin films and its impact on the oxygen surface exchange resistance
Authors: Rupp Ghislain M. , Téllez Helena , Druce John , Limbeck Andreas , Ishihara Tatsumi , Kilner John , Fleig Jürgen
Published: October 2015

Correlation between the surface chemistry of LSC thin films analyzed by LEIS and ICP-MS and the oxygen exchange kinetics.
Exploring the physical properties of Eu2SrCo1.5Mn0.5O7, a new n = 2 member of the Ruddlesden–Popper series (Eu,Sr)n+1(Co,Mn)nO3n+1
Authors: Boulahya Khalid , Hassan Manar , Gil Daniel Muñoz , Romero Julio , Herrero Adrián Gómez , Martin Susana García , Amador Ulises
Published: October 2015

A new oxide of the Ruddlesden–Popper series has been isolated and characterized in the Eu–Sr–Co–Mn–O system.
Facile fabrication of robust superhydrophobic porous materials and their application in oil/water separation
Authors: Hou Yi , Wang Zhen , Guo Jing , Shen Heng , Zhang Huan , Zhao Ning , Zhao Yiping , Chen Li , Liang Songmiao , Jin Yan , Xu Jian
Published: October 2015

A versatile strategy is developed to prepare 2D/3D superhydrophobic porous materials by simply coating substrates with dispersion of PTFPMS aggregations.
Bifunctional MOF heterogeneous catalysts based on the synergy of dual functional sites for efficient conversion of CO2under mild and co-catalyst free conditions
Authors: Ma Dingxuan , Li Baiyan , Liu Kang , Zhang Xianlong , Zou Weijian , Yang Yongquan , Li Guanghua , Shi Zhan , Feng Shouhua
Published: October 2015

We report two ionic liquids functionalized CUSs-containing MOF catalysts, which exhibit high catalyst activity for the cycloaddition of CO2and epoxide.
Solution processable amorphous hafnium silicate dielectrics and their application in oxide thin film transistors
Authors: Gao Y. N. , Xu Y. L. , Lu J. G. , Zhang J. H. , Li X. F.
Published: October 2015

Novel solution-processed amorphous high-k dielectrics for thin film transistors (TFTs) have been systemically studied with the objective of achieving high performance and reducing costs for the next generation displays.
Evaluation of potential acute cardiotoxicity of biodegradable nanocapsules in rats by intravenous administration
Authors: Fracasso Rafael , Baierle Marília , Goëthel Gabriela , Barth Anelise , Freitas Fernando , Nascimento Sabrina , Altknecht Louise , Olsen Virgilio , Paese Karina , da Silva Vinicius Duval , Castro Iran , Andrades Michael , Clausell Nadine , Pohlmann Adriana , Guterres Silvia , Garcia Solange Cristina
Published: October 2015

Nanotoxicology aims to study the safety of nanomaterials, especially towards human exposure. Biodegradable polymeric nanocapsules have been indicated as potential drug carriers applicable for treating several pathologies. Thus, the objective of this study was to evaluate the potential cardiotoxicity of biodegradable lipid-core nanocapsules (LNC) containing poly(ε-caprolactone). Nanocapsules were characterized and the acute toxicity evaluation was conducted in Wistar rats. Two control groups (saline and tween/glycerol) were utilized, and three treated groups were chosen for low, intermediate and high doses: 28.7 × 1012 (LNC-1), 57.5 × 1012 (LNC-2) and 115 × 1012 (LNC-3), expressed as number of nanocapsules per milliliter per kg. Blood pressure measurements were performed in non-anesthetized animals by caudal plethysmography. The electrocardiographic (ECG) and echocardiographic analyses were carried out after anesthesia by isoflurane at two points, prior to treatment and after 14 days. Blood was collected 24 hours and 14 days after treatment. Biochemical and histopathological analyses were performed. During the evaluation period, no deaths, weight loss or clinical signs were observed. Post-treatment systolic pressures (24 h and 14 days) were significantly increased in comparison to pre-treatment in both control groups and treated groups, which is suggested to be as a possible consequence of the infused volume. Serum sodium, potassium, aspartate aminotransferase and alkaline phosphatase, as well as, hematological parameters were within reference values established for rats. ECG showed no indications of cardiotoxicity. Despite the echocardiograms, no alterations in the ejection fraction were found as indicators of cardiotoxicity. Cardiac histopathology also demonstrated no alterations. Therefore, the present results on acute evaluation after i.v. administration, by slow infusion, showed potential safety since no cardiotoxic effects by ECG, echocardiographic, arterial pressure, biochemical and histopathological analyses were found.
Speech Science Applications for Practicing Clinicians and Audiology or Speech-Language Pathology Students
Authors: Bunta Ferenc
Published: October 2015

The advent of widely available, free, and user-friendly speech analysis software in the late 1990s has made it possible to perform acoustic analyses in clinical and educational settings. However, despite the widespread availability and relative ease of use of speech analysis programs, some clinicians are reluctant to adopt hands-on acoustic analyses into their practice. The purpose of the present paper is threefold: (1) to dispel the myth that speech science and acoustic analyses are difficult and only marginally useful for clinical practice, (2) to demonstrate the practical utility—even necessity—of acoustic analyses for practicing as well as future audiologists and speech-language pathologists, and (3) to briefly outline a highly interactive speech science course with integrated hands-on acoustic analyses. Today, more than ever before, a solid background in speech science and extensive experience with acoustic analyses is a necessary part of audiologists' and speech-language pathologists' education, because incorporating speech analyses can enhance clinical practice. Moreover, new technologies demand that clinicians understand the principles behind the programs they and their clients use.