bluuebunny/crossref_metadata_2025 huggingface dataset:
Simplified Calculation Method for Active Anti-Floating of Elliptical Basements by Relief Wells
Authors: Luo Guanyong , Yang Fei , Li Haoxi , Pan Hong , Cao Hong
Published: November 2023

Currently, there are two main types of anti-floating methods for underground structures; one is the passive anti-floating method represented by anti-draft piles, the other is the active anti-floating method which focuses on interceptor-discharge pressure-reducing (IDPR). In the design of an IDPR anti-floating system, the relief well system situated within the cut-off wall serves as the primary drainage channel. The determination of the seepage field distribution within the multi-well system is vital for the overall design. For the seepage field analysis of the IDPR anti-floating multi-well system, currently numerical analysis is usually used, and there is a lack of simplified analysis methods. The simplified analysis methods already available are based on the uniform distribution of wells in circular pits, while the conversion of non-circular pits into circular pits produce large errors, which are not conducive to promoting the use of the method. To address this, we propose a simplified calculation approach suitable for multi-well systems (arbitrary layout) within elliptical pits. The analytical solution of non-uniformly distributed wells in circular pits is deduced through the principle of superposition. Then, the ellipse is mapped into a circle by using conformal mapping. The resistance coefficient method is adopted, and the internal and external seepage fields are connected in series to obtain the total flow rate, as well as the distribution of the seepage field. This is based on the consideration of the permeability of the waterproof curtains and the bypassing seepage. According to the verification of the calculation example, the results of the simplified algorithm are similar to the results of the finite element method, which proves the accuracy of the method; at the same time, when applied to the actual engineering, the obtained calculation results coincide with the measured data, which proves the practicability and reliability of the method. The simplified method can provide an effective way to design an IDPR anti-floating system.
Calculation Method of the Design Thickness of a Frozen Wall with Its Inner Edge Radially Incompletely Unloaded
Authors: Hu Chenchen , Yang Zhijiang , Han Tao , Yang Weihao
Published: November 2023

The technology for freezing shaft sinking is widely used for shafts to pass through deep, unstable alluvia with the continuous exploitation of mineral resources. Due to the technique using the sectional excavation and shaft lining construction adopted in deep alluvia, the radial stress at the inner edge of a frozen wall is incompletely unloaded. In this paper, a mechanical model was established for a frozen wall with its inner edge radially incompletely unloaded. A parameter, α, expressing the degree of being unloaded was introduced, and then a new method of designing and calculating the thickness of the frozen wall was proposed. The range of parameter α was estimated based on the frozen wall–shaft lining interaction forces from field data from a given project. The results indicate that the range of α can be chosen to be from 0.05 to 0.15 in deep alluvia. The design thickness of the frozen wall can be reduced by at least 5% for the frozen wall with the inner edge radially incompletely unloaded. The design thickness is significantly influenced by the strength and elastic modulus of the frozen soil and the elastic modulus of the surrounding unfrozen alluvium. The design and calculation method of frozen wall thickness can provide new ideas for guiding the design of frozen walls in deep alluvia.
Numerical Study on Hydrodynamic Performance of a New Semi-Submersible Aquaculture Platform
Authors: Ding Wei-Wei , Jiang Jia-Qiang , Yue Wan-Zhen , Li Yan-Zhen , Wang Wen-Sheng , Sheng Song-Wei , Chen Min
Published: November 2023

To address the limitations of traditional aquaculture cages, such as poor performance in offshore environments, challenges in energy supply, and the inability to integrate modern farming facilities, a new semi-submersible aquaculture platform has been developed and put into operation. The hydrodynamic performance of the platform is analyzed using a fully coupled numerical model. The numerical model incorporates the main structure of the platform, the net system, and the mooring system, and is based on the linear potential flow theory and the Morison equation. The natural period of the platform is found to be far away from the common wave period. The mooring system for the platform in a specific sea area is proven to be safe. The net system significantly affects the hydrodynamic performance and alleviates the dynamic response of the platform. This study provides valuable insights for researchers and engineers in the design and optimization of this type of semi-submersible aquaculture platform in the future.
Reducing Storage Losses of Organic Apples by Plasma Processed Air (PPA)
Authors: Wagner Robert , Weihe Thomas , Winter Hauke , Weit Christoph , Ehlbeck Jörg , Schnabel Uta
Published: November 2023

The consumer demand for organic food including apples is increasing worldwide. Despite favorable environmental and health benefits, organic farming bears also disadvantages like high amounts of fruit losses due to storage rot. A novel treatment with plasma-processed air (PPA) to sanitize organic apples is investigated. The plasma source for the generation of PPA was operated at a frequency of 2.45 GHz, a power output of 1.1 kW and a gas flow of 18 standard liters per minute. The antimicrobial efficiency of the PPA was tested on the natural load of organic apples (cultivar Natyra) with a load ranging from 104 to 106 CFU/mL in an experimental laboratory setup. A larger application was applied on artificially inoculated (Pseudomonas fluorescens~108 CFU/mL and Pezicula malicorticis~106 CFU/mL) organic apples to test the up-scalability of the PPA treatment. The apples were photographically documented and their texture was analyzed during the 26-day storage phase to investigate the influence of the PPA treatment on the appearance of the apples. The laboratory experiments resulted in a log10-reduction of one to two log10 levels compared to untreated and compressed-air-treated apples. For apples inoculated with P. fluorescens, the up-scaled procedure resulted in up to four levels of log10 reduction. In apples inoculated with P. malicorticis, the up-scaled procedure resulted in no reduction. This indicates that the application of PPA to organic apples can be effective for bacteria but needs to be optimized for fungi. Therefore, further testing is needed to validate the results.
Enhancing Anomaly Detection Models for Industrial Applications through SVM-Based False Positive Classification
Authors: Qiu Ji , Shi Hongmei , Hu Yuhen , Yu Zujun
Published: November 2023

Unsupervised anomaly detection models are crucial for the efficiency of industrial applications. However, frequent false alarms hinder the widespread adoption of unsupervised anomaly detection, especially in fault detection tasks. To this end, our research delves into the dependence of false alarms on the baseline anomaly detector by analyzing the high-response regions in anomaly maps. We introduce an SVM-based false positive classifier as a post-processing module, which identifies false alarms from positive predictions at the object level. Moreover, we devise a sample synthesis strategy that generates synthetic false positives from the trained baseline detector while producing synthetic defect patch features from fuzzy domain knowledge. Following comprehensive evaluations, we showcase substantial performance enhancements in two advanced out-of-distribution anomaly detection models, Cflow and Fastflow, across image and pixel-level anomaly detection performance metrics. Substantive improvements are observed in two distinct industrial applications, with notable instances of elevating the image-level F1-score from 46.15% to 78.26% in optimal scenarios and boosting pixel-level AUROC from 72.36% to 94.74%.
Shared Graph Neural Network for Channel Decoding
Authors: Wu Qingle , Ng Benjamin K. , Lam Chan-Tong , Cen Xiangyu , Liang Yuanhui , Ma Yan
Published: November 2023

With the application of graph neural network (GNN) in the communication physical layer, GNN-based channel decoding algorithms have become a research hotspot. Compared with traditional decoding algorithms, GNN-based channel decoding algorithms have a better performance. GNN has good stability and can handle large-scale problems; GNN has good inheritance and can generalize to different network settings. Compared with deep learning-based channel decoding algorithms, GNN-based channel decoding algorithms avoid a large number of multiplications between learning weights and messages. However, the aggregation edges and nodes for GNN require many parameters, which requires a large amount of memory storage resources. In this work, we propose GNN-based channel decoding algorithms with shared parameters, called shared graph neural network (SGNN). For BCH codes and LDPC codes, the SGNN decoding algorithm only needs a quarter or half of the parameters, while achieving a slightly degraded bit error ratio (BER) performance.
Sustainable Lithium Ferro-Phosphate Cathode Manufacturing: A Semi-Dry Approach with Water-Based Processing and Polytetrafluorethylene Binders
Authors: Wiegmann Eike , Fischer Steffen , Leeb Matthias , Kwade Arno
Published: November 2023

A novel water-based lithium ferro-phosphate (LFP) cathode manufacturing process characterized by a significant reduction in the amount of solvent has been developed (semi-dry). To establish and validate this new process, Polytetrafluorethylene (PTFE) is used as a binder, with a binder content of 1 wt.%, minimizing the amount of inactive material within the electrode. Extrusion screws with multiple kneading zones stress the PTFE more intensively and thus produce more and smaller fibrils. The resulting extent of fibrillation is quantified by melting enthalpy as well as mechanical electrode properties. The degree of fibrillation of the binder in an electrode is known to influence the conductive electric and ionic pathways, which in turn affect the discharge capacity. It is shown that this process provides a flexible cathode layer that achieves a specific capacitance of 155 mAh g−1 in initial cycling tests at 0.1 C. Compared to a conventionally processed LFP cathode, the discharge capacity and overall energy output are significantly increased, and the overall energy consumption decreases for the semi-dry processed LFP cathodes.
Sja-Let-7 Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in a Mouse Model via Col1α2
Authors: Zhong Haoran , Dong Bowen , Zhu Danlin , Li Hao , Lu Ke , Fu Zhiqiang , Liu Jinming , Jin Yamei
Published: November 2023

Liver fibrosis (LF) is a chronic progressive disease with no definitive treatment. The aim of this study was to assess helminth-derived molecules as potential therapeutic targets to prevent or reverse LF. A mouse model of carbon tetrachloride (CCL4)-induced LF was established and sja-let-7 was overexpressed by treatment with a miRNA agomir once per week. After four weeks, serum biochemistry, hepatic hydroxyproline content measurements, liver histology, mRNA expression profiling of fibrotic markers, the dual-luciferase reporter assay, and fluorescence in situ hybridization (FISH) were performed. Administration of the sja-let-7 agomir markedly ameliorated hepatosplenomegaly and reduced the liver hydroxyproline content. Liver histological analysis showed significant reductions in collagen deposition in the sja-let-7 agomir-treated mice. Additionally, the mRNA levels of both pro-fibrotic markers and pro-inflammatory cytokines were diminished after treatment. Furthermore, the dual-luciferase reporter assay and FISH identified the α2 chain of collagen type 1 (Col1α2) as the direct target of sja-let-7. Accordingly, the progression of LF was attenuated by targeting Col1α2 and the TGF-β/Smad signaling pathway.
gRNA Design: How Its Evolution Impacted on CRISPR/Cas9 Systems Refinement
Authors: Motoche-Monar Cristofer , Ordoñez Julián E. , Chang Oscar , Gonzales-Zubiate Fernando A.
Published: November 2023

Over the past decade, genetic engineering has witnessed a revolution with the emergence of a relatively new genetic editing tool based on RNA-guided nucleases: the CRISPR/Cas9 system. Since the first report in 1987 and characterization in 2007 as a bacterial defense mechanism, this system has garnered immense interest and research attention. CRISPR systems provide immunity to bacteria against invading genetic material; however, with specific modifications in sequence and structure, it becomes a precise editing system capable of modifying the genomes of a wide range of organisms. The refinement of these modifications encompasses diverse approaches, including the development of more accurate nucleases, understanding of the cellular context and epigenetic conditions, and the re-designing guide RNAs (gRNAs). Considering the critical importance of the correct performance of CRISPR/Cas9 systems, our scope will emphasize the latter approach. Hence, we present an overview of the past and the most recent guide RNA web-based design tools, highlighting the evolution of their computational architecture and gRNA characteristics over the years. Our study explains computational approaches that use machine learning techniques, neural networks, and gRNA/target interactions data to enable predictions and classifications. This review could open the door to a dynamic community that uses up-to-date algorithms to optimize and create promising gRNAs, suitable for modern CRISPR/Cas9 engineering.
Molecular Insight into Ligand Binding and Transport by the Lentil Lipid Transfer Protein Lc-LTP2: The Role of Basic Amino Acid Residues at Opposite Entrances to the Hydrophobic Cavity
Authors: Melnikova Daria N. , Bogdanov Ivan V. , Potapov Andrey E. , Alekseeva Anna S. , Finkina Ekaterina I. , Ovchinnikova Tatiana V.
Published: November 2023

Lipid transfer proteins (LTPs) realize their functions in plants due to their ability to bind and transport various ligands. Structures of many LTPs have been studied; however, the mechanism of ligand binding and transport is still not fully understood. In this work, we studied the role of Lys61 and Lys81 located near the “top” and “bottom” entrances to the hydrophobic cavity of the lentil lipid transfer protein Lc-LTP2, respectively, in these processes. Using site-directed mutagenesis, we showed that both amino acid residues played a key role in lipid binding to the protein. In experiments with calcein-loaded liposomes, we demonstrated that both the above-mentioned lysine residues participated in the protein interaction with model membranes. According to data obtained from fluorescent spectroscopy and TNS probe displacement, both amino acid residues are necessary for the ability of the protein to transfer lipids between membranes. Thus, we hypothesized that basic amino acid residues located at opposite entrances to the hydrophobic cavity of the lentil Lc-LTP2 played an important role in initial protein–ligand interaction in solution as well as in protein–membrane docking.
Phosphoinositide Signaling in Immune Cell Migration
Authors: Kakar Ruchi , Ghosh Chinmoy , Sun Yue
Published: November 2023

In response to different immune challenges, immune cells migrate to specific sites in the body, where they perform their functions such as defense against infection, inflammation regulation, antigen recognition, and immune surveillance. Therefore, the migration ability is a fundamental aspect of immune cell function. Phosphoinositide signaling plays critical roles in modulating immune cell migration by controlling cell polarization, cytoskeletal rearrangement, protrusion formation, and uropod contraction. Upon chemoattractant stimulation, specific phosphoinositide kinases and phosphatases control the local phosphoinositide levels to establish polarized phosphoinositide distribution, which recruits phosphoinositide effectors to distinct subcellular locations to facilitate cell migration. In this Special Issue of “Molecular Mechanisms Underlying Cell Adhesion and Migration”, we discuss the significance of phosphoinositide production and conversion by phosphoinositide kinases and phosphatases in the migration of different types of immune cells.
Identification and Preliminary Clinical Validation of Key Extracellular Proteins as the Potential Biomarkers in Hashimoto’s Thyroiditis by Comprehensive Analysis
Authors: Xi Zihan , Yang Tinglin , Huang Tao , Zhou Jun , Yang Peng
Published: November 2023

Hashimoto’s thyroiditis (HT) is an autoimmune disruption manifested by immune cell infiltration in thyroid tissue and the production of antibodies against thyroid-specific antigens, such as the thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb). TPOAb and TGAb are commonly used in clinical tests; however, handy indicators of the diagnosis and progression of HT are still scarce. Extracellular proteins are glycosylated and are likely to enter body fluids and become readily available and detectable biomarkers. Our research aimed to discover extracellular biomarkers and potential treatment targets associated with HT through integrated bioinformatics analysis and clinical sample validations. A total of 19 extracellular protein-differentially expressed genes (EP-DEGs) were screened by the GSE138198 dataset from the Gene Expression Omnibus (GEO) database and protein annotation databases. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the function and pathway of EP-DEGs. STRING, Cytoscape, MCODE, and Cytohubba were used to construct a protein–protein interaction (PPI) network and screen key EP-DEGs. Six key EP-DEGs (CCL5, GZMK, CXCL9, CXCL10, CXCL11, and CXCL13) were further validated in the GSE29315 dataset and the diagnostic curves were evaluated, which all showed high diagnostic accuracy (AUC > 0.95) for HT. Immune profiling revealed the correlation of the six key EP-DEGs and the pivotal immune cells in HT, such as CD8+ T cells, dendritic cells, and Th2 cells. Further, we also confirmed the key EP-DEGs in clinical thyroid samples. Our study may provide bioinformatics and clinical evidence for revealing the pathogenesis of HT and improving the potential diagnosis biomarkers and therapeutic strategies for HT.
How Deep Learning in Antiviral Molecular Profiling Identified Anti-SARS-CoV-2 Inhibitors
Authors: Ali Mohammed , Park In Ho , Kim Junebeom , Kim Gwanghee , Oh Jooyeon , You Jin Sun , Kim Jieun , Shin Jeon-Soo , Yoon Sang Sun
Published: November 2023

The integration of artificial intelligence (AI) into drug discovery has markedly advanced the search for effective therapeutics. In our study, we employed a comprehensive computational–experimental approach to identify potential anti-SARS-CoV-2 compounds. We developed a predictive model to assess the activities of compounds based on their structural features. This model screened a library of approximately 700,000 compounds, culminating in the selection of the top 100 candidates for experimental validation. In vitro assays on human intestinal epithelial cells (Caco-2) revealed that 19 of these compounds exhibited inhibitory activity. Notably, eight compounds demonstrated dose-dependent activity in Vero cell lines, with half-maximal effective concentration (EC50) values ranging from 1 μM to 7 μM. Furthermore, we utilized a clustering approach to pinpoint potential nucleoside analog inhibitors, leading to the discovery of two promising candidates: azathioprine and its metabolite, thioinosinic acid. Both compounds showed in vitro activity against SARS-CoV-2, with thioinosinic acid also significantly reducing viral loads in mouse lungs. These findings underscore the utility of AI in accelerating drug discovery processes.
Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance
Authors: Zhuang Xinguo , Martin Tracey A. , Ruge Fiona , Zeng Jianyuan (Jimmy) , Li Xinyu (Amber) , Khan Elyas , Dou Qingping , Davies Eleri , Jiang Wen G.
Published: November 2023

(1) Introduction: Claudin-9 (CLDN9) is a member of the claudin protein family, a critical transmembrane protein family for tight junctions that are implemented in the progression of numerous cancer types. The present study investigated the role that CLDN9, along with the subcoat proteins, Zonula Occludens (ZOs), plays in clinical breast cancer and subsequent impact on drug response of patients. (2) Methods: CLDN9 protein and CLDN9 transcript were determined and correlated with clinical and pathological indicators, together with the status of hormonal receptors. The levels of CLDN9 transcript were also assessed against the therapeutic responses of the patients to chemotherapies by using a dataset from the TCGA database. Breast cancer cell models, representing different molecular subtypes of breast cancer, with differential expression of CLDN9 were created and used to assess the biological impact and response to chemotherapeutic drugs. (3) Results: Breast cancer tissues expressed significantly higher levels of the CLDN9, with the high levels being associated with shorter survival. CLDN9 was significantly correlated with its anchorage proteins ZO-1 and ZO-3. Integrated expression of CLDN9, ZO-1 and ZO-3 formed a signature that was significantly linked to overall survival (OS) (p = 0.013) and relapse-free survival (RFS) (p = 0.024) in an independent matter. CLDN9 transcript was significantly higher in patients who were resistant to chemotherapies (p < 0.000001). CLDN9 connection to chemoresistance was particularly prominent in patients of ER-positive (ER(+)), Her-2-negative((Her-2(−)), ER(+)/Her-2(−) and triple-negative breast cancers (TNBCs), but not in patients with HER-2-positive tumors. In Her-2-negative MCF7 and MDA-MB-231 cancer cells, loss of CLDN9 significantly increased sensitivity to several chemotherapeutic drugs including paclitaxel, gemcitabine and methotrexate, which was not seen in Her-2(+) SKBR3 cells. However, suppressing Her-2 using neratinib, a permanent Her-2 inhibitor, sensitized cellular response to these chemodrugs in cells with CLDN9 knockdown. (4) Conclusions: CLDN9 is an important prognostic indicator for patients with breast cancer and also a pivotal factor in assessing patient responses to chemotherapies. Her-2 is a negating factor for the treatment response prediction value by CLDN9 and negating Her-2 and CLDN9 may enhance breast cancer cellular response to chemotherapeutic drugs.
Interrelation of Hypoxia-Inducible Factor-1 Alpha (HIF-1 α) and the Ratio between the Mean Corpuscular Volume/Lymphocytes (MCVL) and the Cumulative Inflammatory Index (IIC) in Ulcerative Colitis
Authors: Poenariu Ioan Sabin , Boldeanu Lidia , Ungureanu Bogdan Silviu , Caragea Daniel Cosmin , Cristea Oana Mariana , Pădureanu Vlad , Siloși Isabela , Ungureanu Anca Marinela , Statie Răzvan-Cristian , Ciobanu Alina Elena , Gheonea Dan Ionuț , Osiac Eugen , Boldeanu Mihail Virgil
Published: November 2023

We intended to investigate the presence and medical application of serum hypoxia-inducible factor-1 alpha (HIF-1α) along with the already known systemic inflammatory markers and the new one’s inflammatory indices, the proportion of mean corpuscular volume and lymphocytes (MCVL) and the cumulative inflammatory index (IIC), for patients with ulcerative colitis (UC). We sought to establish correlations that may be present between the serum levels of HIF-1α and these inflammatory indices, as well as their relationship with disease activity and the extent of UC, which can provide us with a more precise understanding of the evolution, prognosis, and future well-being of patients. Serum samples were collected from 46 patients diagnosed with UC and 23 controls. For our assessment of the serum levels of HIF-1α, we used the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Thus, for HIF-1α we detected significantly higher values in more severe and more extensive UC. When it came to MCVL and IIC, we observed statistically significant differences between the three groups being compared (Severe, Moderate, and Mild). Our study highlighted that HIF-1α correlated much better with a disease activity score, MCVL, and IIC. With MCVL and IIC, a strong and very strong correlation had formed between them and well-known inflammation indices. By examining the ROC curves of the analyzed parameters, we recognized that TWI (accuracy of 83.70%) provides the best discrimination of patients with early forms of UC, followed by HIF-1α (73.90% accuracy), MCVL (70.90% accuracy), and PLR (70.40%). In our study, we observed that HIF-1α, MCVL, and PLR had the same sensitivity (73.33%) but HIF-1α had a much better specificity (60.87% vs. 58.70%, and 54.35%). Also, in addition to the PLR, HIF-1α and MCVL can be used as independent predictor factors in the discrimination of patients with early forms of UC.
Underactuated Humanoid Peeling Approach for Pickled Mustard Tuber Based on Metamorphic Constraints
Authors: Wan Haochuan , Chen Lei , Xiao Jiayu , Chen Nana , Yin Hankun , Zhang Lin
Published: November 2023

Pickled mustard tuber (PMT), also known as Brassica juncea var. tumida, is a conical tuberous vegetable with a scaly upper part and a coarse fiber skin covering the lower part. Due to its highly distorted and complex heterogeneous fiber network structure, traditional manual labor is still used for peeling and removing fibers from pickled mustard tuber, as there is currently no effective, fully automated method or equipment available. In this study, we designed an underactuated humanoid pickled mustard tuber peeling robot based on variable configuration constraints that emulate the human “insert-clamp-tear” process via probabilistic statistical design. Based on actual pickled mustard tuber morphological cluster analysis and statistical features, we constructed three different types of pickled mustard tuber peeling tool spectral profiles and analyzed the modular mechanical properties of three different tool configurations to optimize the variable configuration constraint effect and improve the robot’s end effector trajectory. Finally, an ADAMS virtual prototype model of the pickled mustard tuber peeling robot was established, and simulation analysis of the “insert-clamp-tear” process was performed based on the three pickled mustard tuber statistical classification selection. The results showed that the pickled mustard tuber peeling robot had a meat loss rate of no more than 15% for each corresponding category of pickled mustard tuber, a theoretical peeling rate of up to 15 pieces per minute, and an average residual rate of only about 2% for old fibers. Based on reasonable meat loss, the efficiency of peeling was greatly improved, which laid the theoretical foundation for fully automated pickled mustard tuber peeling.
Efficacy and Safety of SPN-812 (Extended-Release Viloxazine) in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis
Authors: Tan Xin , Xu Yuejuan , Wang Shixin , Li Jiaxuan , Hu Chunxia , Chen Zhouqing , Cheng Qingzhang , Wang Zhong
Published: November 2023

Background: SPN-812 has been approved for attention-deficit/hyperactivity disorder (ADHD) treatment in children and adolescents. Objective: We aimed to analyze the efficacy and safety of different doses of SPN-812 for ADHD pediatric patients of different ages, verify its clinical efficacy, and evaluate its safety. Methods: Up until 30 August 2023, randomized controlled trials (RCTs) were searched in EMBASE, MEDLINE, the Cochrane Library, and clinicaltrials.gov to evaluate different doses of SPN-812 and a placebo. Results: We pooled 1619 patients from five RCTs with a duration of 6–8 weeks. Patients (6–17 years old) in SPN-812 (100, 200, and 400 mg/d) groups were superior to the control group in all efficacy outcomes with lower attention-deficit/hyperactivity disorder rating scale-5 (ADHD-RS-5), Conners 3-parent short form composite T score (Conners 3-PS), Weiss functional impairment rating scale-parent (WFIRS-P), and increased clinical global impression-improvement (CGI-I) score (both p < 0.05). At the same time, only SPN-812 300 mg/d did not show a significantly high risk of the adverse events (AEs) such as somnolence and decreased appetite (p = 0.09). There was no significant difference between placebo and SPN-812 groups (100, 200, and 400 mg/d) in serious adverse events (SAEs) such as syncope. The subgroup analyses showed that, both in children and adolescents subgroups, SPN-812 showed better efficacy than the placebo. The two age subgroups showed a significantly higher risk of AEs and an insignificant risk of SAEs than the placebo. Conclusion: At present, SPN-812 (100, 200, and 400 mg/d) is superior to the corresponding control in efficacy measures. However, the safety problem cannot be ignored.
Prevalence and Associated Factors of Depression among Adults Suffering from Migraine in Spain
Authors: Cebrino Jesús , Portero de la Cruz Silvia
Published: November 2023

Considering the significance of migraine and the limited amount of research conducted on its association with depression in population-based studies in Spain, this study aimed to determine the prevalence and change of depression from 2017 to 2020 among adults with migraine in Spain and to analyze the sociodemographic and health-related variables linked to depression in migraine sufferers. A cross-sectional study on 5329 adults with migraine from the Spanish National Health Survey 2017 and the European Health Survey in Spain 2020 was performed. Binary logistic regression was used to examine the factors related to depression. A total of 26.32% of people with migraine suffered from depression. No significant changes in that prevalence between 2017 and 2020 were observed. The risk factors associated with depression included being between the ages of 25 and 44 (p = 0.018), being separated or divorced (p = 0.033), being unemployed (p < 0.001), not engaging in recreational physical activity (p = 0.016), perceiving one’s health as average, poor, or very poor (p < 0.001), experiencing moderate to severe pain in daily activities (p = 0.011, p = 0.004, p < 0.001, respectively), and having 1–2 or ≥3 chronic conditions (p = 0.003, p < 0.001, respectively). Conversely, being married (p = 0.001) and alcohol consumption (p = 0.007) were identified as protective factors.
Detection of Subclinical Motor Speech Deficits after Presumed Low-Grade Glioma Surgery
Authors: Mirkoska Vesna , Antonsson Malin , Hartelius Lena , Nylén Fredrik
Published: November 2023

Motor speech performance was compared before and after surgical resection of presumed low-grade gliomas. This pre- and post-surgery study was conducted on 15 patients (mean age = 41) with low-grade glioma classified based on anatomic features. Repetitions of /pa/, /ta/, /ka/, and /pataka/ recorded before and 3 months after surgery were analyzed regarding rate and regularity. A significant reduction (6 to 5.6 syllables/s) pre- vs. post-surgery was found in the rate for /ka/, which is comparable to the approximate average decline over 10–15 years of natural aging reported previously. For all other syllable types, rates were within normal age-adjusted ranges in both preoperative and postoperative sessions. The decline in /ka/ rate might reflect a subtle reduction in motor speech production, but the effects were not severe. All but one patient continued to perform within normal ranges post-surgery; one performed two standard deviations below age-appropriate norms pre- and post-surgery in all syllable tasks. The patient experienced motor speech difficulties, which may be related to the tumor’s location in an area important for speech. Low-grade glioma may reduce maximum speech-motor performance in individual patients, but larger samples are needed to elucidate how often the effect occurs.
District Energy Viewed from the New Bauhaus Initiative Perspective—Sustainable, Inclusive and Aesthetic Heat
Authors: Lygnerud Kristina , Fransson Nathalie , Särnbratt Mirjam , Motoasca Emilia , Neven Thomas , Vanschoenwinkel Janka , Pastor Carolina , Gabaldón Andrea , Belda Alberto
Published: November 2023

(1) Background: To support the energy transition in Europe, the EU has launched multiple initiatives. Supporting the “Green Deal” is the New European Bauhaus (NEB). District heating and cooling (DHC) is an important part of a decarbonized European energy system, and its role in the transition has been stressed by the EU. In this paper, DHC is, for the first time, reviewed assuming the NEB principles. (2) Method: a literature review combined with a review of three cases was used for collecting data. (3) Results: It is confirmed that DHC has strong sustainability values. It is also identified that DHC can become increasingly inclusive by adopting updated digital platforms and new technologies for heat recovery that necessitate close customer interaction whilst recovering waste heat. The least exploited principle is aesthetics. It could sharpen city planning by combining energy system and energy efficiency perspectives, increase the practice of multifunctional buildings (for example energy provision and recreation), and foster a closer interplay between architecture and energy. (4) Conclusions: for both innovating and expanding DHC, the NEB principles can serve as catalysts.
Bacteremia in Patients with Solid Organ Cancer: Insights into Epidemiology and Antibiotic Consumption
Authors: de Dios-García Begoña , Maestro Guillermo , Díaz-Pedroche Carmen , Parra Wagner , Campos Óscar , Orellana María Ángeles , Caro José Manuel , Lumbreras Carlos , Lizasoain Manuel
Published: November 2023

Epidemiology and risk factors associated to bacterial resistance in solid organ cancer (SOC) patients has been barely described. This retrospective monocentric study analyzed clinical variables in SOC patients who developed bacteremia between 1 January 2019 and 31 December 2022. We described rates of bacterial resistance in Gram negative bacteria (80.6%): E. coli-ESBL, K. pneumoniae-ESBL, Carbapenem-Resistant K. pneumoniae and Meropenem-Resistant P. aeruginosa, as well as antibiotic consumption, and compared these rates between the medical and oncology wards. In total, we included 314 bacteremias from 253 patients. SOC patients are frequently prescribed antibiotics (40.8%), mainly fluoroquinolones. Nosocomial bacteremia accounted for 18.2% of the cases and only 14.3% of patients were neutropenic. Hepatobiliary tract was the most frequent tumor (31.5%) and source of bacteremia (38.5%). Resistant bacteria showed a decreased rate of resistance during the years studied in the oncology ward. Both K-ESBL and K-CBP resistance rates decreased (from 45.8% to 20.0%, and from 29.2% to 20.0%, respectively), as well as MRPA, which varied from a resistance rate of 28% to 16.7%. The presence of a urinary catheter (p < 0.001) and previous antibiotic prescription (p = 0.002) were risk factors for bacterial resistance. Identifying either of these risk factors could help in guiding antibiotic prescription for SOC patients.
A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors
Authors: Lee Oswald Zhao Jian , Omar Noorjehan , Tay Joshua K. , Lee Victor Kwan Min
Published: November 2023

The Epstein–Barr virus (EBV) is associated with various tumor types, including nasopharyngeal carcinoma and lymphoproliferative disorders. While much is known about EBV-related epithelial and lymphoid tumors, there is a paucity of knowledge concerning EBV-associated mesenchymal tumors. This review aims to provide a comprehensive overview of EBV-associated mesenchymal tumors, encompassing their clinical features, pathological characteristics, pathophysiology, prognostic factors, and current treatment approaches. Through an extensive literature search using the PubMed database, we were able to identify three distinct EBV-associated mesenchymal tumors: EBV-associated smooth muscle tumors, inflammatory pseudotumor-like follicular dendritic cell sarcomas, and EBV-associated osteosarcomas. Although this review extensively explored the different aspects of these mesenchymal tumors, our comprehension of the underlying pathophysiology in this context is still incomplete. Therefore, we hope that this review paper will not only serve as a valuable repository of information but also serve as a catalyst for prospective in vitro and in vivo research studies to bridge the existing knowledge gap surrounding pathophysiology, ultimately making an important contribution to shaping future therapeutic approaches.
Involved-Site Radiation Therapy Enables Effective Disease Control in Parenchymal Low-Grade Primary Cerebral Lymphoma
Authors: Pepper Niklas Benedikt , Oertel Michael , Reinartz Gabriele , Elsayad Khaled , Hering Dominik Alexander , Yalcin Fatih , Wildgruber Moritz , Stummer Walter , Lenz Georg , Klapper Wolfram , Eich Hans Theodor
Published: November 2023

Background: Primary lymphoma of the central nervous system (PCNSL) encompasses a variety of lymphoma subtypes, with the majority being diffuse large B-cell lymphomas, which require aggressive systemic treatment. In contrast, low-grade lymphomas are reported infrequently and are mostly limited to dural manifestations. Very rarely, parenchymal low-grade PCNSL is diagnosed, and the cases documented in the literature show a wide variety of treatment approaches. Methods: We screened all cases of PCNSL treated at our department (a tertiary hematooncology and neurooncology center) in the last 15 years and conducted a comprehensive literature research in the PubMed database. Results: Overall, two cases of low-grade primary parenchymal PCNSL treated with irradiation were identified. The dose prescriptions ranged from 30.6 to 36 Gy for the involved site, with sparing of the hippocampal structures. Both patients had an excellent response to the treatment with a mean follow-up of 20 months. No clinical or radiological signs of treatment toxicity were detected. Conclusions: Our analysis corroborates the results from the literature and demonstrates that parenchymal low-grade PCNSL shows a good response to localized radiation treatment, enabling a favorable outcome while avoiding long-term treatment toxicity.
Two Faces of Glutaminase GLS2 in Carcinogenesis
Authors: Buczkowska Joanna , Szeliga Monika
Published: November 2023

In rapidly proliferating cancer cells, glutamine is a major source of energy and building blocks. Increased glutamine uptake and enhanced glutaminolysis are key metabolic features of many cancers. Glutamine is metabolized by glutaminase (GA), which is encoded by two genes: GLS and GLS2. In contrast to isoforms arising from the GLS gene, which clearly act as oncoproteins, the role of GLS2 products in tumorigenesis is far from well understood. While in some cancer types GLS2 is overexpressed and drives cancer development, in some other types it is downregulated and behaves as a tumor suppressor gene. In this review, we describe the essential functions and regulatory mechanisms of human GLS2 and the cellular compartments in which GLS2 has been localized. Furthermore, we present the context-dependent oncogenic and tumor-suppressor properties of GLS2, and delve into the mechanisms underlying these phenomena.
Evolution of the Management of Brain Metastases: A Bibliometric Analysis
Authors: Burney Ikram A. , Aal Hamad Aya H. , Hashmi Syed F. A. , Ahmad Nisar , Pervez Nadeem
Published: November 2023

A systematic review of the published literature was conducted to analyze the management evolution of brain metastases from different cancers. Using the keywords “brain metastasis”, “brain metastases”, “CNS metastasis”, “CNS metastases”, “phase III” AND/OR “Randomized Controlled Trial” (RCT), relevant articles were searched for on the SCOPUS database. A total of 1986 articles were retrieved, published over a 45-year period (1977–2022). Relevant articles were defined as clinical studies describing the treatment or prevention of brain metastases from any cancer. Articles on imaging, quality of life, cognitive impairment after treatment, or primary brain tumors were excluded. After a secondary analysis, reviewing the abstracts and/or full texts, 724 articles were found to be relevant. Publications significantly increased in the last 10 years. A total of 252 articles (34.8%) were published in 12 core journals, receiving 50% of the citations. The number of publications in Frontiers in Oncology, BMC Cancer, and Radiotherapy and Oncology have increased considerably over the last few years. There were 111 randomized controlled trials, 128 review articles, and 63 meta-analyses. Most randomized trials reported on brain metastases management from unselected tumors (49), lung cancer (47), or breast cancer (11). In the last 5 years (2017 to 2022), management of brain metastasis has moved on from WBRT, the use of chemotherapy, and radio-sensitization to three directions. First, Radiosurgery or Radiotherapy (SRS/SRT), or hippocampal-sparing WBRT is employed to reduce radiation toxicity. Second, it has moved to the use of novel agents, such as tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICI) and third, to the use of molecularly directed therapy such as TKIs, in asymptomatic low volume metastasis, obviating the need for WBRT.
Complementary Approaches to Retinal Health Focusing on Diabetic Retinopathy
Authors: Rák Tibor , Kovács-Valasek Andrea , Pöstyéni Etelka , Csutak Adrienne , Gábriel Róbert
Published: November 2023

Diabetes mellitus affects carbohydrate homeostasis but also influences fat and protein metabolism. Due to ophthalmic complications, it is a leading cause of blindness worldwide. The molecular pathology reveals that nuclear factor kappa B (NFκB) has a central role in the progression of diabetic retinopathy, sharing this signaling pathway with another major retinal disorder, glaucoma. Therefore, new therapeutic approaches can be elaborated to decelerate the ever-emerging “epidemics” of diabetic retinopathy and glaucoma targeting this critical node. In our review, we emphasize the role of an improvement of lifestyle in its prevention as well as the use of phytomedicals associated with evidence-based protocols. A balanced personalized therapy requires an integrative approach to be more successful for prevention and early treatment.
Effect of Ultrasonic Treatment on Microstructure and Properties of 2000 MPa Ultra-High-Strength Steel-Welded Joints
Authors: Chu Qibao , Wang Gang , Yuan Ren , Xu Xiangyu
Published: November 2023

The microstructure and mechanical properties of ultra-high-strength steel weld joints were examined for the effect of ultrasonic treatment. ER120S-G welding wire is necessary for welding 4 mm thick ultra-high-strength steel. After that, the weld toe region underwent different parameters of the ultrasonic stress relief process. As a means of surface treatment for weld seams, noticeable grain refinement and the formation of a fine-grained layer were observed in the weld toe region after ultrasonic treatment. The blind hole method was used to measure residual stresses in the weld seam, which indicated a transition from tensile stress to compressive stress in the treated portion of the joint. Different ultrasonic treatment processes resulted in a significant increase in hardness values near the weld toe region during hardness testing. The hardness of the weld joint that was treated with ultrasound increased initially but then stabilized after increasing the frequency. The ultrasound-treated joints showed a significant improvement in both tensile strength and fracture elongation, as demonstrated in the tensile tests.
Endocrine Disruptors in Cosmetic Products and the Regulatory Framework: Public Health Implications
Authors: Kalofiri Paraskevi , Biskanaki Foteini , Kefala Vasiliki , Tertipi Niki , Sfyri Eleni , Rallis Efstathios
Published: November 2023

Endocrine disruptors (EDs) are molecules capable of mimicking the natural hormones of the body and interfering with the endocrine system in both humans and wildlife. Cosmetic products are one source of EDs; these include an extensive variety of personal care and beauty products designed for the skin and hair, as well as makeup. The widespread use of such products has raised concerns about the presence of EDs within them. In this study, we highlight the issue of EDs and analyze the functioning of the EU regulatory framework for chemicals, specifically those which act as EDs in cosmetic products. We also highlight issues related to the interface between science and policy in the critical area of risk regulation within the EU. In addition, we investigate how chemical substances that act as EDs are identified based on specific criteria and conditions, a process which involves the production and adoption of particular scientific opinions. Finally, we assess the efficiency, suitability, and effectiveness of the regulatory framework in this sensitive area of human exposure to chemicals, especially those that function as EDs.
Cerium-Doped Oxide-Based Materials for Energy and Environmental Applications
Authors: Kim Suhwan , Choi Minho , Park Jongsung
Published: November 2023

Cerium is a rare-earth metal commonly used as a dopant in various metal oxides to enhance their performances or provide optoelectronic properties. Cerium oxide (ceria) is particularly valuable owing to its unique properties and applications in various fields, such as biomedical research, photovoltaics, and industrial catalytic processes. This review focuses on the use of cerium and ceria doping in the synthesis of SiO2 and ZnO. Studies have shown that Ce-doped SiO2 thin films exhibit luminescence properties and proton shielding capabilities, and that Ce-doped ZnO has potential applications in gas sensors. In this review, we highlight the potential for controlling the luminescence and optical characteristics of these materials via cerium doping, opening up possibilities for various technological advancements and potential applications of cosmic ray shielding in space photovoltaics.