bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S1, S2 from DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
Authors: Miller Abigail L. , Perurena Naiara , Gardner Alycia , Hinoue Toshinori , Loi Patrick , Laird Peter W. , Cichowski Karen
Published: May 2023

Table S1: Genes enriched in tumor macrophages, Table S2: The methylation of RASGAPs in human colorectal cancer (TCGA)
Supplementary Data from The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response
Authors: Zhang Lei , Li Yuqing , Zhou Lingli , Zhou Houhong , Ye Liefu , Ou Tong , Hong Huaishan , Zheng Shiwen , Zhou Ziyu , Wu Kang , Yan Zeqin , Thiery Jean Paul , Cui Jun , Wu Song
Published: May 2023

Supplementary Data clean version
Supplementary Data from A Self-Propagating c-Met–SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness
Authors: Huang Xinmei , Zhang Shenghua , Tang Jingshu , Tian Tian , Pan Yilin , Wu Lina , Zhang Jingxuan , Liu Yang , Huang Jing , Dai Hui , Xu Weiyan , Zhang Youhui , Chen Jinfeng , Cao Mengshu , Zhang Liang , Qiu Xiaoyan
Published: May 2023

Supplementary figures and tables.
Supplementary Table 4 from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Authors: Lo Emily K.W. , Mears Brian M. , Maurer H. Carlo , Idrizi Adrian , Hansen Kasper D. , Thompson Elizabeth D. , Hruban Ralph H. , Olive Kenneth P. , Feinberg Andrew P.
Published: May 2023

Pairwise mean-based differentially methylated regions
Supplementary Information from Dual Impact of IGF2 on Alveolar Stem Cell Function during Tobacco-Induced Injury Repair and Development of Pulmonary Emphysema and Cancer
Authors: Boo Hye-Jin , Min Hye-Young , Park Choon-Sik , Park Jong-Sook , Jeong Ji Yun , Lee Shin Yup , Kim Woo-Young , Lee Jae-Won , Oh Sei-Ryang , Park Rang-Woon , Lee Ho-Young
Published: May 2023

Supplementary Methods, Tables, and Figures
Supplementary Table 3 from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Authors: Lo Emily K.W. , Mears Brian M. , Maurer H. Carlo , Idrizi Adrian , Hansen Kasper D. , Thompson Elizabeth D. , Hruban Ralph H. , Olive Kenneth P. , Feinberg Andrew P.
Published: May 2023

Motif analysis
Supplementary Table 2 from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Authors: Lo Emily K.W. , Mears Brian M. , Maurer H. Carlo , Idrizi Adrian , Hansen Kasper D. , Thompson Elizabeth D. , Hruban Ralph H. , Olive Kenneth P. , Feinberg Andrew P.
Published: May 2023

Variant and mutation calling
Supplementary Table 1 from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Authors: Lo Emily K.W. , Mears Brian M. , Maurer H. Carlo , Idrizi Adrian , Hansen Kasper D. , Thompson Elizabeth D. , Hruban Ralph H. , Olive Kenneth P. , Feinberg Andrew P.
Published: May 2023

WGBS quality control metrics
Supplementary Tables from Large B-cell Lymphomas of Immune-Privileged Sites Relapse via Parallel Clonal Evolution from a Common Progenitor B Cell
Authors: Los-de Vries G. Tjitske , Stathi Phylicia , Rutkens Ryanne , Hijmering Nathalie J. , Luijks Jeroen A.C.W. , Groenen Patricia J.T.A. , de Jong Daphne , Ylstra Bauke , Roemer Margaretha G.M.
Published: May 2023

Supplementary Tables
Supplementary Table from Terminally Exhausted CD8+ T Cells Resistant to PD-1 Blockade Promote Generation and Maintenance of Aggressive Cancer Stem Cells
Authors: Chakravarti Mohona , Dhar Sukanya , Bera Saurav , Sinha Abhipsa , Roy Kamalika , Sarkar Anirban , Dasgupta Shayani , Bhuniya Avishek , Saha Akata , Das Juhina , Banerjee Saptak , Vernekar Manisha , Pal Chiranjib , Alam Neyaz , Datta Dipak , Baral Rathindranath , Bose Anamika
Published: May 2023

Contains supplementary table ST1, ST2 and ST3.
Data from BCA101 is a Tumor-Targeted Bifunctional Fusion Antibody that Simultaneously Inhibits EGFR and TGF-β Signalling to Durably Suppress Tumor Growth
Authors: Boreddy Srinivas Reddy , Nair Reshmi , Pandey Prashant Kumar. , Kuriakose Anshu , Marigowda Shivakumar Bhadravathi. , Dey Chaitali , Banerjee Arindam , Kulkarni Hanumant , Sagar Milind , Krishn Shiv Ram , Rao Shruthi , A R Madhukara , Tiwari Vinita , Alke Bhavna , MV Prashantha Kumara , Shri Meena , Dhamne Chaitrali , Patel Sonal , Sharma Pinky , Periyasamy Sankar , Bhatnagar Jaya , Kuriakose Moni Abraham. , Reddy Ram Bhupal , Suresh Amritha , Sreenivas Suma , Govindappa Nagaraja , Moole Praveen Reddy. , Bughani Usha , Tan Seng-Lai , Nair Pradip
Published: May 2023

Abstract
The EGFR and TGF-β signalling pathways are important mediators of tumorigenesis, and crosstalk between them contributes to cancer progression and drug resistance. Therapies capable of simultaneously targeting EGFR and TGF-β could help improve patient outcomes across various cancer types. Here, we developed BCA101, an anti-EGFR IgG1 monoclonal antibody linked to an extracellular domain of human TGF-βRII. The TGF-β “trap” fused to the light chain in BCA101 did not sterically interfere with its ability to bind EGFR, inhibit cell proliferation, or mediate antibody-dependent cellular cytotoxicity. Functional neutralization of TGF-β by BCA101 was demonstrated by several in vitro assays. BCA101 increased production of proinflammatory cytokines and key markers associated with T and NK cell activation, while suppressing VEGF secretion. Additionally, BCA101 inhibited differentiation of naïve CD4+ T cells to inducible T-regulatory (iTreg) cells more strongly than the anti-EGFR antibody cetuximab. BCA101 localized to tumor tissues in xenograft mouse models with comparable kinetics to cetuximab, both having better tumor tissue retention over TGF-β “trap”. TGF-β in tumors was neutralized by approximately 90% in animals dosed with 10 mg/kg of BCA101 compared to 54% in animals dosed with equimolar TGF-βRII-Fc. In patient-derived xenograft mouse models of head and neck squamous cell carcinoma, BCA101 showed durable response post dose cessation. The combination of BCA101 and anti-PD1 antibody improved tumor inhibition in both B16-hEGFR expressing syngeneic mouse models and in humanized HuNOG-EXL mice bearing human PC-3 xenografts. Together, these results support the clinical development of BCA101 as a monotherapy and in combination with immune checkpoint therapy.
Data from Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Authors: Lo Emily K.W. , Mears Brian M. , Maurer H. Carlo , Idrizi Adrian , Hansen Kasper D. , Thompson Elizabeth D. , Hruban Ralph H. , Olive Kenneth P. , Feinberg Andrew P.
Published: May 2023

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is believed to arise from the accumulation of a series of somatic mutations and is also frequently associated with pancreatic intraepithelial neoplasia (PanIN) lesions. However, there is still debate as to whether the cell type-of-origin of PanINs and PDACs in humans is acinar or ductal. As cell type identity is maintained epigenetically, DNA methylation changes during pancreatic neoplasia can provide a compelling perspective to examine this question. Here, we performed laser-capture microdissection on surgically resected specimens from 18 patients to isolate, with high purity, DNA for whole-genome bisulfite sequencing from four relevant cell types: acini, nonneoplastic ducts, PanIN lesions, and PDAC lesions. Differentially methylated regions (DMR) were identified using two complementary analytical approaches: bsseq, which identifies any DMRs but is particularly useful for large block-like DMRs, and informME, which profiles the potential energy landscape across the genome and is particularly useful for identifying differential methylation entropy. Both global methylation profiles and block DMRs clearly implicated an acinar origin for PanINs. At the gene level, PanIN lesions exhibited an intermediate acinar-ductal phenotype resembling acinar-to-ductal metaplasia. In 97.6% of PanIN-specific DMRs, PanIN lesions had an intermediate methylation level between normal and PDAC, which suggests from an information theory perspective that PanIN lesions are epigenetically primed to progress to PDAC. Thus, epigenomic analysis complements histopathology to define molecular progression toward PDAC. The shared epigenetic lineage between PanIN and PDAC lesions could provide an opportunity for prevention by targeting aberrantly methylated progression-related genes.
Significance:
Analysis of DNA methylation landscapes provides insights into the cell-of-origin of PanIN lesions, clarifies the role of PanIN lesions as metaplastic precursors to human PDAC, and suggests potential targets for chemoprevention.
The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Authors: Foote Michael B. , Walch Henry , Kemel Yelena , Vakiani Efsevia , Johannet Paul , Sheehan Margaret , Chatila Walid , Chung Sebastian , Nash Garrett M. , Maio Anna , Shia Jinru , Mandelker Diana , Berger Michael , Schultz Nikolaus , Diaz Luis A. , Cercek Andrea , Stadler Zsofia K.
Published: May 2023

Purpose:

More than 10% of assessed patients with appendiceal adenocarcinoma have a pathogenic (P) or likely pathogenic (LP) germline variant, including genes implicated in heritable gastrointestinal cancer syndromes, such as Lynch syndrome. We defined the clinical and molecular impact of heritable alterations in appendiceal adenocarcinoma to evaluate the need for dedicated appendiceal screening and prevention strategies in patients with LP/P germline variants.

Experimental Design:

We performed an integrated germline and somatic molecular analysis for patients with confirmed appendiceal adenocarcinoma. Patients underwent paired tumor-normal sequencing for up to 90 hereditary cancer risk genes and 505 genes for somatic mutation profiling. We defined the cooccurrence of LP/P germline variants and second-hit pathogenic somatic alterations. The associations between germline variants and patient clinicopathologic features were also evaluated.

Results:

Twenty-five of 237 patients (10.5%) carried pathogenic or likely pathogenic germline variants in cancer susceptibility genes. Clinicopathologic characteristics and appendiceal adenocarcinoma–specific survival were similar in patients with or without germline variants. Most (92%, N = 23/25) patients with germline variants demonstrated no second-hit somatic alterations, including loss of heterozygosity. Two patients with a germline APC I1307K low-penetrance founder variant exhibited secondary somatic pathogenic alterations in APC. However, only one patient tumor exhibited APC-mediated WNT signaling dysregulation: a plausible consequence of multiple somatic APC mutations with no germline variant contribution. Four patients had germline variants in PMS2 or MSH2 associated with Lynch syndrome, yet their cancers were microsatellite-stable.

Conclusions:

Germline variants are likely incidental without a contributory driver role in appendiceal adenocarcinoma. Appendiceal adenocarcinoma screening in patients with germline variants is not clearly merited.
Supplementary Table 1 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Authors: Mender Ilgen , Siteni Silvia , Barron Summer , Flusche Ann Marie , Kubota Naoto , Yu Chunhua , Cornelius Crystal , Tedone Enzo , Maziveyi Mazvita , Grichuk Anthony , Venkateswaran Niranjan , Conacci-Sorrell Maralice , Hoshida Yujin , Kang Rui , Tang Daolin , Gryaznov Sergei , Shay Jerry W.
Published: May 2023

Supplementary Table 1
Figure S1-S5 from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Authors: Mender Ilgen , Siteni Silvia , Barron Summer , Flusche Ann Marie , Kubota Naoto , Yu Chunhua , Cornelius Crystal , Tedone Enzo , Maziveyi Mazvita , Grichuk Anthony , Venkateswaran Niranjan , Conacci-Sorrell Maralice , Hoshida Yujin , Kang Rui , Tang Daolin , Gryaznov Sergei , Shay Jerry W.
Published: May 2023

Supplementary Data
Data from Activating an Adaptive Immune Response with a Telomerase-mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma
Authors: Mender Ilgen , Siteni Silvia , Barron Summer , Flusche Ann Marie , Kubota Naoto , Yu Chunhua , Cornelius Crystal , Tedone Enzo , Maziveyi Mazvita , Grichuk Anthony , Venkateswaran Niranjan , Conacci Sorrell Maralice , Hoshida Yujin , Kang Rui , Tang Daolin , Gryaznov Sergei , Shay Jerry W.
Published: May 2023

Abstract
A select group of hepatocellular carcinomas (HCC) patients benefit from surgical, radiological, and systemic therapies that include a combination of anti-angiogenic and immune-checkpoint inhibitors. However, since HCC is generally asymptomatic in its early stages, this not only leads to late diagnosis, but also to therapy resistance. The nucleoside analogue 6-thio-dG (THIO) is a first-in-class telomerase-mediated telomere-targeting anticancer agent. In telomerase expressing cancer cells, THIO is converted into the corresponding 5’-triphosphate, which is efficiently incorporated into telomeres by telomerase, activating telomere damage responses and apoptotic pathways. Here, we show how THIO is effective in controlling tumor growth and, when combined with immune checkpoint inhibitors, is even more effective in a T-cell dependent manner. We also show telomere stress induced by THIO increases both innate sensing and adaptive anti-tumor immunity in HCC. Importantly, the extracellular HMGB1 (high-mobility group box 1) protein acts as a prototypical endogenous DAMP (Damage Associated Molecular Pattern) in eliciting adaptive immunity by THIO. These results provide a strong rationale for combining telomere-targeted therapy with immunotherapy.
Data from Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody–Drug Conjugate
Authors: Groothuis Patrick G. , Jacobs Daniëlle C.H. , Hermens Inge A.T. , Damming Désirée , Berentsen Kim , Mattaar-Hepp Ellen , Stokman Marloes E.M. , Boekel Tinie van , Rouwette Myrthe , van der Vleuten Monique A.J. , Sesink Aloys , Dijcks Fred A. , Coumans Ruud G.E. , Schouten Jan , Glaudemans Dirk H. , Wijk Daniëlle van , Blomenröhr Marion , Kappers Wendela A. , Ubink Ruud , van der Lee Miranda M.C. , Dokter Wim H.A.
Published: May 2023

Abstract
MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. BYON3521 is a novel site-specifically conjugated duocarmycin-based antibody–drug conjugate (ADC), comprising a humanized cysteine-engineered IgG1 monoclonal antibody with low pmol/L binding affinity towards both human and cynomolgus MET. In vitro studies showed that BYON3521 internalizes efficiently upon MET binding and induces both target- and bystander-mediated cell killing. BYON3521 showed good potency and full efficacy in MET-amplified and high MET–expressing cancer cell lines; in moderate and low MET–expressing cancer cell lines good potencies and partial efficacy were observed. In mouse xenograft models, BYON3521 showed significant antitumor activity upon single-dose administration in multiple non-MET–amplified tumor types with low, moderate, and high MET expression, including complete tumor remissions in models with moderate MET expression. In the repeat-dose Good Laboratory Practice (GLP) safety assessment in cynomolgus monkeys, BYON3521 was well tolerated and based on the observed toxicities and their reversibility, the highest non-severely toxic dose was set at 15 mg/kg. A human pharmacokinetics (PK) model was derived from the PK data from the cynomolgus safety assessments, and the minimal efficacious dose in humans is estimated to be in the range of 3 to 4 mg/kg. In all, our nonclinical data suggests that BYON3521 is a safe ADC with potential for clinical benefit in patients. A first-in-human dose-escalation study is currently ongoing to determine the maximum tolerated dose and recommended dose for expansion (NCT05323045).
Table S1 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: May 2023

Primers and Antibodies used in this paper.
Supplemental Figures from mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
Authors: Nirschl Christopher J. , Brodkin Heather R. , Domonkos Celesztina , Dwyer Connor J. , Hicklin Daniel J. , Ismail Nesreen , Seidel-Dugan Cynthia , Steiner Philipp , Steuert Zoe , Sullivan Jenna M. , Winston William M. , Salmeron Andres
Published: May 2023

Supplemental Figures 1-10
Supplementary Figure 4 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: May 2023

Supplementary Figure 4
Figure S2 from Chemokine Analysis in Patients with Metastatic Uveal Melanoma Suggests a Role for CCL21 Signaling in Combined Epigenetic Therapy and Checkpoint Immunotherapy
Authors: Sah Vasu R. , Jespersen Henrik , Karlsson Joakim , Nilsson Lisa M. , Bergqvist Mattias , Johansson Iva , Carneiro Ana , Helgadottir Hildur , Levin Max , Ullenhag Gustav , Ståhlberg Anders , Olofsson Bagge Roger , Nilsson Jonas A. , Ny Lars
Published: May 2023

Figure S2. a) Gene signatures implicating short term survival. Statistical tests were carried out using DESeq2 and FDR-adjusted P-values were denoted with *, P < 0.05; **, P < 0.01; ***, P < 0.001. b) Average of TK1 values assessed for all timepoints by the number of timepoints divided among response groups, PD, SD, PR. c) TK1 values in different response groups
Evaluation of kidney injury through early markers in canine pyometra
Authors: Andrade Andrezza Cavalcanti de , Silva Érica Pereira da , Santos Joana D'Arc dos , Oliveira Karina Pessoa , Silva Karla Patrícia Chaves da , Notomi Márcia Kikuyo
Published: May 2023

Fourteen female dogs diagnosed with pyometra were studied at three separate times: at diagnosis (T0) and 24 h (T1) and 10-15 days (T2) after ovariohysterectomy (OH). The means of the markers, symmetric dimethylarginine (SDMA) (17.71 to 26.54 μg/dL) and the urinary gamma-glutamyl transferase to creatinine ratio (uGGT/uCr) (1.06 to 2.62 U/mg), varied, showing an increase with time. Further, the elevation of gamma-glutamyl transferase (uGGT) (56.61 to 128.12 U/L) and the urinary protein to creatinine ratio (RPC) (0.26 to 1.24) was evident at T0 and T1. A reduction in the means of RPC, uGGT, and uGGT/uCr was observed 10-15 days after OH. Despite the elevation of these markers, the concentration of creatinine (1.11 to 1.40 mg/dL), urea (40.07 to 67.16 mg/dL), and urinary specific gravity (1.027 to 1.028) only presented slight variation. In canine pyometra, complications secondary to acute renal injury may be present that may be mild and transient in most treated animals. As elevation in SDMA and RPC preceded changes in creatinine levels for the evaluation of glomerular filtration, tubular markers could assist in the early identification of renal damage in canine pyometra.
Traduzione, interpretazione e comunicazione nel lessico di Luigi Pirandello
Authors: Dugo Sandra
Published: May 2023

Questo articolo propone uno studio sui problemi di traduzione alla luce di alcune teorie di Walter Benjamin, Antoine Berman e Henri Meschonnic. Nei casi di presunta intraducibilità è necessario ricostruire il testo con una nuova stesura, assumendo un altro codice linguistico, costituito dai sinonimi dell’idioma portoghese; in questa sfida il traduttore sembra un traditore dell’opera originale, ma non lo è, perché la nuova creazione è una re-interpretazione inter-testuale e una ri-elaborazione linguistica e stilistica, nelle quali affiorano differenze e somiglianze fra i due idiomi. Possiamo considerare la traduzione come il processo di comunicazione fra l’autore dell’opera originale e il lettore al quale è destinata. Propongo la lettura di alcuni brani delle novelle Il fumo e Il ventaglino, tradotte in portoghese e pubblicate recentemente da Francisco Degani, per riflettere sulla differenza fra due lingue di origine neo-latina, l’italiano e il portoghese, che è l’incontro fra due diversi contesti culturali, sociali e storici.
La sombra del Condor: breve panorama de Arqueología de la represión y la resistencia en America del Sur
Authors: Zarankin Andrés , López Mazz Jose Maria , Maguire Pedro Pablo Fermin
Published: May 2023

En el marco de la “guerra fría”, durante la segunda mitad del siglo XX, América Latina se vio inmersa en una serie de golpes militares y actuaciones conjuntas de ejércitos estimulados por las políticas anticomunistas de los EEUU. Estas dictaduras dejaron herencias nefastas de todo tipo, y con las cuales nuestras frágiles democracias continúan teniendo que enfrentar, aun después de pasadas décadas desde su caída. En este contexto, la arqueología viene mostrado su potencial para ayudar a comprender los crímenes cometidos, recuperar los restos de los desaparecidos y reflexionar sobre las políticas de la memoria. En este trabajo señalamos algunas de las direcciones fundamentales de los trabajos arqueológicos sobre la dictadura, sus principales contribuciones y las posibles direcciones para el futuro.
Hierarchical organization of spontaneous co-fluctuations in densely sampled individuals using fMRI
Authors: Betzel Richard F. , Cutts Sarah A. , Tanner Jacob , Greenwell Sarah A. , Varley Thomas , Faskowitz Joshua , Sporns Olaf
Published: May 2023

Edge time series decompose functional connectivity into its framewise contributions. Previous studies have focused on characterizing the properties of high-amplitude frames (time points when the global co-fluctuation amplitude takes on its largest value), including their cluster structure. Less is known about middle- and low-amplitude co-fluctuations (peaks in co-fluctuation time series but of lower amplitude). Here, we directly address those questions, using data from two dense-sampling studies: the MyConnectome project and Midnight Scan Club. We develop a hierarchical clustering algorithm to group peak co-fluctuations of all magnitudes into nested and multiscale clusters based on their pairwise concordance. At a coarse scale, we find evidence of three large clusters that, collectively, engage virtually all canonical brain systems. At finer scales, however, each cluster is dissolved, giving way to increasingly refined patterns of co-fluctuations involving specific sets of brain systems. We also find an increase in global co-fluctuation magnitude with hierarchical scale. Finally, we comment on the amount of data needed to estimate co-fluctuation pattern clusters and implications for brain-behavior studies. Collectively, the findings reported here fill several gaps in current knowledge concerning the heterogeneity and richness of co-fluctuation patterns as estimated with edge time series while providing some practical guidance for future studies.
Rethinking Historical Aspects
Authors: Imaz-Sheinbaum Mariana
Published: May 2023

Explaining the persistence of multiple interpretations of the same historical event has been an ongoing question in the philosophy of history. In this paper I illustrate two possible answers and argue that neither offers a satisfactory resolution. First of all, the realist view, which holds a metaphysical commitment to the past that precludes it from fully recognizing the legitimacy of variability of historical interpretations. Second, Ankersmit’s representationalism which seeks to overcome the realist view by introducing the notion of aspects. Nevertheless, I contend that this latter position ultimately proves indistinguishable from the sort of realist commitments it claims to avoid. In order to overcome these views, I argue that a new conception of historical aspects is needed. By developing a Wittgensteinian notion of aspect seeing, I provide a novel account of historical explanation. Wittgenstein’s insights allow us not only to explain the multiplicity of historical accounts but also to recognize the epistemic activity that goes into historiographical construction.
Impact of North Indian Atmospheric Diabatic Heating on Summer Precipitation in Central Asia
Authors: Wei Yun , Yu Haipeng , Li Shuanglin , Zhu Zhiwei , Yang Yaoxian , Ren Yu , Liu Chenxi , Zhou Jie
Published: May 2023

The impact of North Indian atmospheric diabatic heating variation on summer rainfall over Central Asia (CA) at an interannual scale during 1960–2019 was investigated from thermal adaptation and water vapor transportation perspective. The results showed that more precipitation in southeastern CA is associated with the southward subtropical westerly jet (SWJ), caused by the ascending motion and weakened water vapor output on the south side. When the SWJ moves southward, the high-level water vapor transportation on the south side changes from outward (−1.9 × 106 kg s−1) to inward (0.6 × 106 kg s−1), and the positive anomalous relative vorticity advections by the basic westerly winds produce ascending anomalies over southeastern CA. The position change in the SWJ was mainly related to atmospheric diabatic heating over northern India (NI). The thermal vorticity adaptation caused by a weakened heating rate over NI leads to an anomalous upper-level cyclone over southeastern CA, and the associated cold temperature advection eventually cools the upper troposphere of southeastern CA and reduces the temperature gradient at mid-to-high latitudes, leading to the southward SWJ. Thermal adaptation of the circulation and temperature anomaly over southeastern CA to the NI thermal forcing were also verified by numerical experiments. Both the abnormal ascending motions and the weakened outward water vapor associated with the southward SWJ, caused by the weakened heating rate over NI, lead to more summer rainfall in southeastern CA. The changes in diabatic heating over NI are closely related to Indian Ocean SST. When the Indian Ocean SST is warmer, the south Asian summer monsoon weakens, causing less precipitation and, thus, a weakened heating rate over NI.

Significance Statement

This study established that the northern Indian atmospheric diabatic heating anomalies associated with Indian Ocean SST variation play an important role in influencing precipitation in central Asia (CA). The weakening of the atmospheric diabatic heating over the NI would not only cause an abnormal cyclone and cooling over southern CA through thermal adaptation but also lead to southward subtropical westerly jet (SWJ), ascending motions, and decreased outward water vapor on the south side in southeastern CA, eventually resulting in more precipitation in southeastern CA. The results emphasize the influence of tropical SST and atmospheric heat sources on midlatitude climate and are important for understanding summer precipitation change in southeastern CA.
Comparative Analysis of the Hearing Effects of Partial Ossicular Replacement Prosthesis Versus Conchal Cartilage in Canal Wall Down Mastoidectomy with Type II Tympanoplasty: A Retrospective Case Review Study
Authors: Lu Fei , Zhu Qingwen , Fan Bei , Zhang Yukai , Zhou Min , Zha Dingjun , Chen Yang
Published: May 2023

Objectives

To investigate the effects of titanium partial ossicular replacement prosthesis (PORP) and conchal cartilage for ossiculoplasty on hearing results in single-stage canal wall down (CWD) mastoidectomy surgery with type II tympanoplasty in patients with cholesteatoma.

Methods

The patients were performed surgeries for the first time by a senior otosurgeon from 2009 to 2022 and were performed CWD mastoidectomy with type II tympanoplasty in one stage were enrolled. Patients who could not be followed up were excluded. Titanium PORP or conchal cartilage was used for ossiculoplasty. When the stapes head was intact, a cartilage 1.2–1.5 mm thick was attached directly to the stapes; when the head of the stapes was eroded, a 1 mm high PORP and cartilage of .2–.5 mm thick were placed on the stapes simultaneously.

Results

148 patients were included in the study in total. The titanium PORP and conchal cartilage groups showed no statistically significant differences at 500, 1000, 2000, and 4000 Hz considering the number of decibels of closure of the air-bone gap (ABG) ( P > .05) and pure-tone average ABG (PTA-ABG) ( P > .05). Meanwhile, the closure of PTA-ABG between the 2 groups showed no statistically significant differences in the overall distribution ( P > .05).

Conclusions

For patients with cholesteatoma and mobile stapes who underwent CWD mastoidectomy with type II tympanoplasty in one stage, either PORP or conchal cartilage is a satisfactory material for ossiculoplasty.
Cognitive and interdisciplinary mobility in the social sciences and humanities: Traces of increased boundary crossing
Authors: Eykens Joshua , Guns Raf , Engels Tim CE , Vandermoere Frédéric
Published: May 2023

This study presents knowledge diffusion analyses for researchers who have been active in the social sciences and humanities. We compare a network based on switches between the main disciplinary classifications of the documents authored throughout their careers to a discipline similarity network. We find that researchers are not exclusively switching between disciplines that are most similar cognitively. Only less than a third of the authors do not switch between disciplines. On the level of the individual researchers, we also study how the cognitive distance travelled relates to boundary crossing. The cognitive distance authors travel is approximated by calculating cosine distances between the vectors of title records for different periods of activity. Moving to new disciplines is found to be positively related to the cognitive distance an author travels throughout her career. Increased specialisation leading to different types of disciplinary boundary work is suggested as a potential explanation for this finding.
The professor and his legacy: Introducing the Forum
Authors: Dinerstein Ana Cecilia
Published: May 2023

The contributions to the Forum refer to Simon Clarke’s ‘two stages of the same project’, as Clarke explained regarding Marx’s work. They make apparent that Clarke’s initial intellectual contributions to the critique of political economy, form analysis, value theory, theory of the state and money were essential to his later understanding of the collapse and metamorphosis of the former URSS State Socialism into a capitalist form, and his analysis of the political implications of such transformation on labour relations, working-class interests and class struggle in Russia, other Eastern European countries, China, and Vietnam.
Modeling, performance enhancement, and the NOx emission reductions of the triple-pressure reheat water-recuperated air-cooled gas turbine combined cycle power plant using interstage compressor water injection and optimization
Authors: Bassily A M
Published: May 2023

Interstage compressor water injection (ICWI) reduces the work of an air compressor, air temperature at its outlet, adiabatic flame temperature, and NOx emissions. When ICWI is introduced to combined cycles, it decreases the surge margin for the air compressor and increases the mass flow rates of the gas through the gas turbine (GT) and generated steam for the heat recovery steam generator and, therefore, power output. For the combined cycle with ICWI, air with two distinct characteristics (before and after ICWI) is used to cool the GT and mix with the expanded gas. In this paper, ICWI was introduced to the triple-pressure reheat air-cooled GT combined cycle. Detailed modeling was carried out for the processes of compression, ICWI, combustion, and GT expansion. Constraints were imposed on the amount of injected water and its temperature and pressure leading to a practical application of ICWI and a safe surge margin for the air compressor. The efficiency of the combined cycle with ICWI was optimized relative to the pressure of ICWI, injected water temperature, and relative humidity of air at the outlet of the water injector at different values of turbine inlet temperatures and air compression ratios. The results indicated that ICWI and optimization could reduce the initial NOx emissions by more than 90% (the NOx emissions that are produced at the adiabatic flame temperature) and enhance cycle efficiency by 1.9 to 2.7 percentage points and power output by 27 to 34 percent. The water recovery system could produce a significant amount of water that exceeds twice the injected amount at no fuel cost and could be integrated into the cycle at no additional equipment costs if CO2 capture or exhaust gas recirculation was implemented.
The Impact of Homelessness, Substance Use, and Mental Illness on Surgical Inpatient Outcomes in Australia
Authors: Warburton Thomas Mostyn , Rush Levon Delaney , Cullen Emma Grace Ruthven , Wiener Jonathan Harry , McManus Bryan Thomas Kelvin , Heath Lucienne , Evans David
Published: May 2023

This study investigated inpatient surgical outcomes for people experiencing homelessness (PEH) in Australia. Retrospective administrative health data of emergency surgical admissions from a single center over five years, 2015 to 2020, was included. Independent associations between factors and outcomes were analyzed with binary logistic and log-linear regression. Of 11 229 admissions, 2% were experiencing homelessness. People experiencing homelessness were on average younger (49 vs 56 years), more likely to be males than females (77% vs 61%), suffer mental illness (10% vs 2%), and substance use disorders (54% vs 10%). People experiencing homelessness were not more likely to suffer surgical complications. However, male sex, older age, mental illness, and substance use were risk factors for poor surgical outcomes. Homelessness predicted greater odds of discharge against medical advice (4.3 times) and longer length of stay (1.25 times). These results highlighted the need for health interventions simultaneously addressing physical, mental health, and substance use issues in the care of PEH.
Relation between erythropoietin resistance and metabolic syndrome in hemodialysis patients: A multicentric propensity score matched analysis
Authors: Kotb Essam , El mancy Ismail Mohamed , Mohamed Ibrahim Ghounim Ramadan , Ayoub Hazem Sayed Ahmed , Rashed AL-Sayed M , EL-Nasser Waleed S , Hamed Hani Ismail , Aladl Hossam Aladl , Sabrh Mostafa , Eliwa Ahmed , Ghamry Esam M , Elmonier Rady , Abd El Fattah Mahmoud Osama Ahmed , El sheref Saad El Deen Mohamed , Mahmoud Tamer M
Published: May 2023

Erythropoietin (EPO) resistance is frequently reported in hemodialysis (HD) patients. Metabolic syndrome (MetS) is a common biochemical condition that comprises central obesity, dyslipidemia, hypertension, and hyperglycemia. The present study aimed to assess the relation between MetS and EPO resistance in HD patients. The present multicentric study included 150 patients with EPO resistance and 150 patients without EPO resistance. Short-acting EPO resistance was diagnosed if the erythropoietin resistance index is ≥1.0 IU/kg/gHb. Comparison between patients with EPO resistance and patients without resistance revealed that the former group had significantly higher body mass index, lower hemoglobin levels, lower albumin levels, higher ferritin levels, and higher high-sensitivity C-reactive protein (hsCRP) levels. In addition, patients in the EPO resistance group had significantly higher frequency of MetS (75.3% vs 38.0%, p < 0.001) and higher number of MetS components (2.7 ± 1.3 vs 1.8 ± 1.6, p < 0.001). Multivariate logistic regression analysis identified lower albumin levels (OR (95% CI): 0.072 (0.016–0.313), p < 0.001), higher ferritin levels (OR (95% CI): 1.05 (1.033–1.066), p< 0.001), higher hsCRP levels (OR (95% CI): 1.041 (1.007–1.077), p = 0.018), and MetS (OR (95% CI): 36.68 (2.893–465.05), p = 0.005) as predictors of EPO resistance in the studied patients. The present study identified MetS as a predictor of EPO resistance in HD patients. Other predictors include serum ferritin, hsCRP, and albumin levels.
Fair-Weather Voters: Personality and Vote Switching Intentions
Authors: Pruysers Scott , Blais Julie
Published: May 2023

While numerous explanations for vote-switching have been proposed (e.g. declining rates of partisanship, ideological shifts, partisan ambivalence, change in policy preferences), far less work has examined the personality profile of people more likely to engage in this behaviour. In Study 1, we examined the relationship between both general (i.e. openness, conscientiousness) and antagonistic (i.e. psychopathy, narcissism, Machiavellianism) personality traits and the intent to switch one’s vote in a large sample of Canadian citizens, while controlling for several established correlates such as age, income and political interest. Of all personality traits, only individuals higher in openness reported a greater intent to engage in vote switching. Despite our expectations, Machiavellianism, a trait characterized by its strategic nature, was unrelated to vote switching intentions. In Study 2, we addressed several methodological reasons for why antagonistic traits may have been unrelated to vote switching intentions in Study 1 by examining the traits at the facet level and utilizing a new measure of Machiavellianism among a separate sample of Canadian citizens. Here again, we found little evidence for a relationship between antagonistic traits, including Machiavellianism, and vote switching intentions.
The Strong Correlation Between Pain Interference and Abnormal Nutritional Status in Older Adults With Chronic Musculoskeletal Pain
Authors: Komolsuradej Narucha , Srikrajang Siwaluk , Rangsiprakarn Norrapat , Wongaree Arya , Wasusathapon Chonnapat , Kanjanakomut Darat , Nukaew Vannarat , Cheutalay Wannasak , Kaewpipat Suppawit , Hoonthong Sirinkit , Ung Sochealing , Iamthanaporn Khanin
Published: May 2023

Objectives:

Musculoskeletal pain, one of the most common issues faced by older adults, has multidimensional effects including an increased risk of malnutrition. Therefore, this study aimed to investigate the association between pain interference and nutritional status in older adults with chronic musculoskeletal pain.

Methods:

In this cross-sectional study, data were collected from older adults (age: >60 years) using the brief pain inventory and mini nutritional assessment questionnaire. The correlation between pain interference, pain severity, and nutritional status was assessed using the chi-square test and Spearman’s rank correlation. Multiple logistic regression analysis was used to analyze the variables associated with abnormal nutrition status.

Results:

Overall 241 older adults were recruited in the study. The median (IQR) age of the participants was 70 (11) years, pain severity subscale was 4.2 (1.8), and pain interference subscale was 3.3 (3.1). Abnormal nutritional status was positively correlated with pain interference (Odds ratio [OR]: 1.26; 95% confidence interval [CI]: 1.08-1.48; P = .004), pain severity (OR: 1.25; 95% CI: 1.02-1.53; P = .034), age (OR 1.06; 95% CI: 1.01-1.11, P = .011), and hypertension (OR = 2.17; 95% CI: 1.11-4.26; P = .024).

Conclusions:

This study reports a strong correlation between pain interference and nutritional status. Therefore, pain interference can be a useful pain assessment tool to indicate risk of abnormal nutritional status in older adults. In addition, related factors, including age, underweight, and hypertension, were associated with a higher risk of malnutrition.
Nurturing Employee Engagement at Workplace and Organizational Innovation in Time of Crisis With Moderating Effect of Servant Leadership
Authors: Dalain Ali Falah
Published: May 2023

The current study strives to examine the impact of HR practices, working condition, intergroup relations, goal congruence, passion for work and organizational learning culture toward employee engagement and organizational innovation. In addition to that the moderating effect of servant leadership is tested between employee engagement and organizational innovation. The research design of this study is grounded in quantitative research approach. Data were retrieved from employees working in Saudi manufacturing organizations. Overall, 241 respondents have participated in this voluntarily research survey. Research framework was tested with structural equation modeling technique. Results revealed that human resource practices, working condition, intergroup relations, passion for work, goal congruence and organizational learning culture have explained large variance [Formula: see text] 52.8% in measuring employee work engagement. Similarly, organizational innovation is measured with employee work engagement and servant leadership and explained substantial 55% variance in organizational innovation. Likewise, the results of the blindfolding analysis revealed substantial predictive power [Formula: see text] 41.4 to predict organizational innovation. Therefore, in determining employee work engagement at workplace goal congruence has shown substantial effect size [Formula: see text] when compared with other exogenous constructs. Practically, this research suggests that goal congruence, human resource practices, and servant leadership are core factors which enhance employee engagement at workplace and organizational innovation in time of crisis and therefore need managerial attention. This study is unique as it examines employee engagement behavior with an integrative research framework. In addition to that the role of servant leadership has been studied as moderator between the relationship of employee engagement and organizational innovation.
Identification of unique transcriptomic signatures through integrated multispecies comparative analysis and WGCNA in bovine oocyte development
Authors: Zhang Fa-Li , Li Wei-Dong , Zhang Geng , Zhang Min , Liu Zhao-Jun , Zhu Ke-Xin , Liu Qing-Chun , Zhang Shu-Er , Shen Wei , Zhang Xi-Feng
Published: May 2023

Background

Cattle (Bos taurus) are a major large livestock, however, compared with other species, the transcriptional specificity of bovine oocyte development has not been emphasised.

Results

To reveal the unique transcriptional signatures of bovine oocyte development, we used integrated multispecies comparative analysis and weighted gene co-expression network analysis (WGCNA) to perform bioinformatic analysis of the germinal follicle (GV) and second meiosis (MII) gene expression profile from cattle, sheep, pigs and mice. We found that the expression levels of most genes were down-regulated from GV to MII in all species. Next, the multispecies comparative analysis showed more genes involved in the regulation of cAMP signalling during bovine oocyte development. Moreover, the green module identified by WGCNA was closely related to bovine oocyte development. Finally, integrated multispecies comparative analysis and WGCNA picked up 61 bovine-specific signature genes that participate in metabolic regulation and steroid hormone biosynthesis.

Conclusion

In a short, this study provides new insights into the regulation of cattle oocyte development from a cross-species comparison.
Modifications in steroid and triterpenoid metabolism in Calendula officinalis plants and hairy root culture in response to chitosan treatment
Authors: Rogowska Agata , Pączkowski Cezary , Szakiel Anna
Published: May 2023

Background

Chitosan, a deacetylated derivative of chitin, is one of the most preferred biopolymers for use as biostimulants and biofertilizers in organic agriculture and as elicitors to enhance the productivity of plant in vitro cultures. Valued as a non-toxic, biodegradable, and environment-friendly agent, it is widely applied to improve plant growth and yield, the content of bioactive specialized metabolites, and resistance to stress conditions and pathogens. However, the influence of chitosan on the growth-defense trade-off, particularly the interplay between steroid and triterpenoid metabolism, has not been extensively investigated.

Results

In this study, Calendula officinalis pot plants and hairy root cultures exposed to chitosan treatment displayed reduced biomass and altered steroid and triterpenoid metabolism. Biosynthesis and accumulation of free forms of sterols (particularly stigmasterol) were inhibited, while the content of sterol esters increased remarkably. The content of some triterpenoids (mainly free triterpenoid acids) was slightly enhanced; however, the biosynthesis of triterpenoid saponins was negatively affected.

Conclusions

These results indicate that in certain plants, chitosan treatment might not positively influence the growth and metabolite production. Therefore, to avoid unexpected effects, initial studies of the conditions of chitosan treatment are recommended, including the dose and the number of chitosan applications, the type of treatment (e.g., foliar or soil), and the vegetative stage of the treated plants.
Frequencies and reasons for unplanned emergency department return visits by older adults: a cohort study
Authors: van Loon-van Gaalen Merel , Voshol Ilje E. , van der Linden M. Christien , Gussekloo Jacobijn , van der Mast Roos C.
Published: May 2023

Background

As unplanned Emergency Department (ED) return visits (URVs) are associated with adverse health outcomes in older adults, many EDs have initiated post-discharge interventions to reduce URVs. Unfortunately, most interventions fail to reduce URVs, including telephone follow-up after ED discharge, investigated in a recent trial. To understand why these interventions were not effective, we analyzed patient and ED visit characteristics and reasons for URVs within 30 days for patients aged ≥ 70 years.

Methods

Data was used from a randomized controlled trial, investigating whether telephone follow-up after ED discharge reduced URVs compared to a satisfaction survey call. Only observational data from control group patients were used. Patient and index ED visit characteristics were compared between patients with and without URVs. Two independent researchers determined the reasons for URVs and categorized them into: patient-related, illness-related, new complaints and other reasons. Associations were examined between the number of URVs per patient and the categories of reasons for URVs.

Results

Of the 1659 patients, 222 (13.4%) had at least one URV within 30 days. Male sex, ED visit in the 30 days before the index ED visit, triage category “urgent”, longer length of ED stay, urinary tract problems, and dyspnea were associated with URVs. Of the 222 patients with an URV, 31 (14%) returned for patient-related reasons, 95 (43%) for illness-related reasons, 76 (34%) for a new complaint and 20 (9%) for other reasons. URVs of patients who returned ≥ 3 times were mostly illness-related (72%).

Conclusion

As the majority of patients had an URV for illness-related reasons or new complaints, these data fuel the discussion as to whether URVs can or should be prevented.

Trial registration

For this cohort study, we used data from a randomized controlled trial (RCT). This trial was pre-registered in the Netherlands Trial Register with number NTR6815 on the 7th of November 2017.