bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of in-hospital mortality by logistic regression analysis among melioidosis patients in Northern Malaysia
Authors: Mardhiah Kamaruddin , Wan-Arfah Nadiah , Naing Nyi Nyi , Hassan Muhammad Radzi Abu , Chan Huan-Keat
Published: July 2021

Objective:

To identify the predictors of mortality among in-hospital melioidosis patients.

Methods:

A total of 453 patients in Hospital Sultanah Bahiyah, Kedah, and Hospital Tuanku Fauziah, Perlis with culture-confirmed melioidosis were retrospectively included in the study. Advanced multiple logistic regression was used to obtain the final model of predictors of mortality from melioidosis. The analysis was performed using STATA/SE 14.0.

Results:

A total of 50.11% (227/453) of the patients died at the hospital, and a majority (86.75%, 393/453) of cases were bacteremic. The logistic regression estimated that the bacteremic type of melioidosis, low platelet count, abnormal white blood cell counts, and increased urea value were predictors of mortality. The results showed that bacteremic melioidosis increased the risk of death by 4.39 times (OR 4.39, 95% CI 1.83-10.55, P=0.001) compared to non-bacteremic melioidosis. Based on laboratory test, the adjusted ORs from the final model showed that all three blood investigations were included as the associated factors of mortality for the disease [high white blood cell (>10×109/L): OR 2.43, 95% CI 1.41-4.17, P<0.001; low white blood cell (<4×109/L): OR 3.82, 95% CI 1.09-13.34, P=0.036; low platelet (<100×109/L): OR 4.19, 95% CI 1.89-9.30, P<0.001; high urea (>7 800 μmol/L): OR 5.53, 95% CI 2.50-12.30, P<0.001; and low level of urea (<2 500 μmol/L): OR 3.52, 95% CI 1.71-7.23, P=0.001).

Conclusions:

Routine blood investigations during a hospital admission can early identify predictors of mortality in melioidosis patients.
A Study on Impact of Corona Virus Disease 2019 Pandemic on Activities of Daily Living, Play, and Sensory Behaviors of Children with Autism Spectrum Disorder
Authors: Nithya G Daris , Damodaran V , Mythili V
Published: July 2021

Background:

New Corona Virus Disease 2019 (COVID-19) pandemic has a greater influence on all of us and has changed many of our everyday routines. Adjusting to a new routine is stressful for everyone, but especially for children with Autism who have difficulty with change, it is more stressful. As, insistence on sameness, inflexible adherence to routines, and ritualistic patterns are the core features of autism, environmental changes, home confinement, disrupted daily routines, restricted access to schools, therapy centers during this pandemic will have a unique impact on children with Autism and their families.

Objectives:

The objective of this study was to systematically assess the impact of the COVID-19 pandemic on activities of daily living (ADL), play, and sensory behaviors of children with autism spectrum disorder (ASD).

Study Design:

Cross-sectional survey study was conducted.

Methods:

Convenient sampling method was used. The study sample consisted of 100 parents/primary caregivers of children with Autism. A structured ADL, play, sensory behavior questionnaire (45 items) was designed, validated, and administered through face to face and telephonic interviews. The duration of the study was 1 month.

Results:

Substantial proportion of the parents (69%) reported inconsistent daily routines and inconsistent sleep routines (67%) since the COVID-19 pandemic. Eighty-three percent of ASD children spend more time on mobile phones and televisions than interactive play. Home confinement during this pandemic resulted in lower physical activity was mentioned by 69% of ASD parents and 70% mentioned the increased social withdrawal of ASD. Many parents reported increased intensity of vestibular-proprioceptive seeking (75%), other sensory behaviors during this COVID-19 pandemic.

Conclusion:

The study analysis suggests that COVID-19 pandemic has a major impact on children with ASD on their ADL, play, and sensory behaviors. Ninety nine percent of our study respondents were not able to access therapy centers, and other intervention facilities during this pandemic. Lack of access to these structured environments during this pandemic could have contributed to the worsening of ASD children's behaviors. So, this study stress, access to the health care services that serve ASD children, especially occupational therapy, needs to be considered essential and remain available during these kinds of pandemics with universal precautions and/or via alternative modes of delivery, i.e. tele-consultation.
Development of Scope of Practice of Occupational Therapy in India
Authors: Mani Karthik , Rao Ashwini , Krishnan Murali , Moorthy Shobana , Ramakrishnan Jothikumar , Karunakaran Naresh Babu
Published: July 2021

An official scope of practice (SOP) is a critical document for any healthcare profession as it defines the profession's scope and protects its boundary from encroachment by unqualified individuals. It is a key document referred by professional regulators when regulating healthcare professions. This article outlines the development process utilized by the Indian Occupational Therapists Think Tank to develop an official SOP document for the profession of occupational therapy in India.
Predictors of Clinical Relapse in Patients with New-Onset Inflammatory Bowel Disease
Authors: Wu Hao , Tian Delin , Cai Hao , Gong Renjie , Kun Kaixiao , Xu Can-Xia
Published: July 2021

Background and Aims:

Inflammatory bowel disease (IBD) usually follows a pattern of more or less frequent relapses of alterable duration, interspersed with periods of remission. Various clinical predictors have been broadly studied, but the research study populations reported are mostly from Western countries.

Methods:

From January 2013 to December 2018, 106 new-onset Crohn's disease (CD) patients and 76 new-onset ulcerative colitis (UC) patients were followed up for a median of 12 months or until relapse. The predictors of clinical relapse were analyzed according to demographic, clinical, histological, endoscopic, and imaging variables.

Results:

In multivariate analysis, predictors of relapse were age of onset <35 years (hazard ratio [HR] = 5.236; 95% confidence interval [CI] 1.252–22.222; P = 0.023) in CD patients and poor medication adherence (HR = 2.070; 95% CI 1.018–4.202; P = 0.044) in UC patients.

Conclusion:

Younger age of onset and poor medication adherence increases the risk of clinical relapse in CD and UC, respectively.
Urogenital Schistosomiasis in Libya, a Case Report and Evaluation of the Current Situation
Authors: Saadawi Walid K. , Gashout Aisha S. , Aldobea Nadia M. , Amro Ahmad Y. , Annajar Badereddin B.
Published: July 2021

Urogenital Schistosomiasis is a parasitic worm disease caused by Schistosoma haematobium and transmitted through the penetration of the human skin by swimming infective larva (Cercaria). Here, we report a new sporadic case of Urinary schistosomiasis in Ubari city in South-West Libya. A 25-year-old male was presented with a history of hematuria, backpain, abdominal, and kidney pain since 2017. The diagnosis of urogenital Schistosomiasis was confirmed by microscopic identification of terminal-spined schistosome eggs and red blood cells in urine samples. The patient was treated with a single dose of 40 mg/kg Praziquantel. By follow-up, a complete recovery of urinary symptoms was observed with no evidence of schistosome eggs in urine. In conclusion, the local health authorities should take proper measures to establish new elimination programs of schistosomiasis, and to increased awareness of this especially in old endemic areas where reemerging of schistosomiasis is most likely.
Clinical Characteristics and Management Practice among Patients Diagnosed with Atrial Ibrillation in Benghazi Libya, A Cross Sectional Study
Authors: Elkadiki Abdelhadi H. , Ali Mohammed A. , Alsaeiti Khaled D.
Published: July 2021

Introduction:

There are no data so far regarding the frequency and outcome of the different types of atrial fibrillation (AF) in the clinical setting for Libyan patients. Furthermore, it is unknown whether the actual clinical management and therapy of AF in Libya conform to the international guidelines. The aim of this study was to determine the frequency, demographic, and clinical characteristics of AF patients.

Patients and Methods:

Three hundred patients attending the outpatient clinic and cardiology department at Benghazi Medical Center and National Cardiac Center between May 2020 and October 2020 were included. Patients' data were obtained through medical records using the chart review. Patients were categorized into a clinical type of AF, based on the physician's perception of the AF at the time of presentation.

Results:

Three hundred patients with an established diagnosis of AF were enrolled, including 210 (70%) females and 90 (30%) males. The mean age at the time of diagnosis was 49.5 ± 21.5 years, with an age range of 29–79 years. Of them 139 (46.3%) were diagnosed as permanent AF, 132 (44%) paroxysmal AF, while new-onset AF was diagnosed in 29 (9.7%). The three clinical categories of AF were enrolled under the care of both cardiologists and internal medicine physicians, but permanent AF patients were more often enrolled under the care of a cardiologist. Patients with permanent AF were older compared with those with paroxysmal subtype (61.8 ± 9 and 50.1 ± 12, respectively), with significant female predominance (P = 0.03), and more often had coronary artery disease (CAD), valvular heart disease, and a previous stroke/TIA (P = 0.01, P = 0.124, and P = 0.002, respectively). Diabetes was the most prevalent associated medical condition, followed by hypertension and hyperlipidemia. CAD was diagnosed among 122 patients. Of permanent AF patients, 28 patients (20.1%) previously suffered from a stroke, mostly TIA, in contrast to 14 patients (10.6%) of the other AF patients.

Conclusion:

Our AF patients were characterized by an unfavorable cardiovascular risk profile. We recognize a lower rate of oral anticoagulation prescription, which needs further evaluation.
Performance Evaluation of Seven Commercial Real-Time Polymerase Chain Reaction Assays for SARS-COV-2 Detection
Authors: ElJilani Mouna Mohamed , Abdusalam Mohamed , Abdalla Adel , Dalyoum Tarek , Ahmad Salah , Alhudiri Inas , Elzagheid Adam
Published: July 2021

Background

/

Aim:

Since the emergence of the severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) pandemic in Wuhan, China, several efforts are being focused on the development of fast and reliable diagnostic molecular tests. Real-time polymerase chain reaction (RT-PCR) based assay on respiratory specimens was recommended by the World Health Organization as the gold standard for early diagnosis of infection spread. Our study aimed to compare the analytical performance of seven commercially available RT-PCR assays.

Materials and Methods:

A total of 33 nasopharyngeal swabs were analyzed by: Da An, PerkinElmer, Norgen, Prestige, PhoenixDX, Bio-Speedy, and Xpert Xpress RT-PCR assays. Sensitivity and detection rates of SARS-COV-2 target genes were analyzed.

Results:

Da An and Xpert Xpress assays showed the highest detection rate and percentage for SARS-COV-2 target genes; (16/33) 48.5%, followed by PerkinElmer and Norgen kits (13/33) 39.4%, (10/33) 30.3%, respectively. However, Prestige, PhoenixDx, and Bio-speedy displayed the same performance (6/33) 18.2%.

Conclusion:

The analyzed assays showed inconsistent analytical performance. Overall, findings reported in our study may not be applicable to other RT-PCR assays or thermocyclers; analytical sensitivities and positive-negative cut-off values should be locally validated.
Prevalence of Bacterial Vaginosis and their Antibiotic Susceptibility among Women Attending Different Private Clinics in Tripoli, Libya
Authors: Atia Ahmed
Published: July 2021

Background:

Bacterial vaginosis is a worldwide issue due to the raised risk of acquisition of sexually transmitted infections. The aim of the study was to assess the incidence of bacterial vaginosis and their antimicrobial pattern in women attending different private clinics in Tripoli, Libya.

Methods:

A cross-sectional study was conducted among 204 women between January and October 2020. Gram-stained vaginal swabs were examined microscopically, characterized by colony morphology, and their antimicrobial susceptibility pattern was determined.

Results:

The overall prevalence of bacterial vaginosis was 41%. Out of 48 bacterial isolates, 76.1% were gram-positive and 23.8% were Gram-negative bacteria. The overall drug resistance level of gram-positive bacteria was high against penicillin, co-amoxiclav, and amoxicillin. Vancomycin and imipenem were the most active drugs against Gram-positive bacteria. High level of drug resistance of Gram-negative bacteria against co-amoxiclav. Ceftriaxone, cefotaxime, and amikacin were the most active drugs against Gram-negative bacteria.

Conclusions:

The prevalence of bacterial vaginosis was high. Routine culture of vaginal samples should be performed on patients with vaginitis and the drug susceptibility pattern of each isolate should be determined.
Rare case of giant myoepithelioma in minor salivary glands of palate in a 9-year-old child
Authors: Patankar Swapna , Sharma Reshmi , Patankar Amod , Kulkarni Venkatesh
Published: July 2021

Myoepitheliomas (MEs) are extremely rare benign neoplasms composed of ectodermally derived contractile smooth muscle cells (myoepithelial cells). Various tissues such as the salivary glands, breast, larynx, and sweat glands show the presence of these myoepithelial cells. They occur, principally, in the parotid gland and infrequently in minor salivary glands. The term “Myoepitheliomas” was first coined by Sheldon in 1943. It is an uncommon salivary gland tumor which accounts for < 1% of all major and minor salivary gland tumors. Batasakis considers the ME to be “one-sided” variant at the opposite end of the spectrum from the pleomorphic adenoma. There are distinct histological and immunohistochemical characteristics of the tumor which aid in the diagnosis. ME of the palate is uncommon, and only a limited number of cases have been reported in the English literature. It shows a benign clinical course with recurrence in up to 20% of cases without metastasis. The present article sheds light on the presence of ME of minor salivary glands in the palate of 9-year-old child.
Comparison of the efficiency of arm force versus arm force plus wrist movement in closed method extractions an observational study
Authors: Sundaram Prashanth , Kandasamy Saravanan , John Reena Rachel , Sri K. C. Keerthana
Published: July 2021

Backgound:

Atraumatic dental extraction preserves not only the bone, but also maintains the gingival architecture, hence allows immediate or late dental implant placement. The incidence of fracture of roots and buccal cortical plates increases when wrong force is used. Currently, there is insufficient literature evidence with regard to the appropriate method for application of arm and wrist force at the time of dental extraction.

Aim:

Therefore, the aim of the present study was to compare the efficiency of arm force only versus arm force plus wrist movement during closed extractions.

Materials and Methods:

The patients who underwent extractions of right upper molars (n = 50) in the Oral and Maxillofacial Surgery Department were selected for the study after obtaining Informed Consent. The patients with grossly decayed broken teeth and mobile teeth were excluded. The procedure was carried out by interns and was observed by three maxillofacial surgeons of more than 5 years of experience independently.

Results:

It was observed that 30% of the trainees used arm only force during dental extraction and were unaware about it. The time taken for tooth removal in the group which used arm and wrist force was significantly lesser (P < 0.001). It was also observed that the breakage of tooth and alveolar bone fracture was more common with the group who used only arm force.

Conclusion:

From the results of the present study, it can be concluded that during exodontia procedures, the principle of using arm and wrist facilitates safe and easy removal of tooth with less time.
Implant survival in patients with neuropsychiatric, neurocognitive, and neurodegenerative disorders
Authors: Bera Rathindra Nath , Tripathi Richik , Bhattacharjee Bappaditya , Singh Akhilesh Kumar , Kanojia Shweta , Kumar Vikram
Published: July 2021

Neurologic disorders impede oral hygiene measures and routine clinical follow-up, along with the various drugs used may jeopardise oral health and the peri- implant tissue health. A total of 7 studies were considered eligible for the current systematic review. The overall estimated effect was categorized as significant where P < 0.05. Funnel plot was used to assess the publication bias within the studies. Difference in means was used as principal summary measure. P value <0.05 was considered as statistically significant. 1069 implants survived in test group and 4677 implants survived in control group (odds ratio: 2.58, 95% CI: 1.93-3.43) indicating significant success in patient without any disorders or taking medications for these disorders. Subgroup analysis was done to check the implant survival rate in patients taking selective serotonin reuptake inhibitors (SSRI) compared with SSRI non-users. Subgroup analysis showed that SSRI non-users had higher implant survival rate than patients taking SSRI (odds ratio: 2.45, 95% CI: 1.82-3.31). Serotonin significantly inhibits bone mineralization and osteoblast differentiation. The presence of any form of neuropsychiatric or neuromuscular disorders precludes proper oral hygiene and may contribute towards implant failure.
Impact of COVID-19 on oral and maxillofacial surgery practice in India
Authors: Vishwakarma Kuldeep , Khakhla Deepakkumar Hamirbhai , Ambereen Aafiya , Rawat Saurabh Kumar , Mishra Prabhaker , Shukla Bharat
Published: July 2021

Study Design:

The Coronavirus disease-19 (COVID-19) pandemic has disrupted oral and maxillofacial (OMF) surgeons’ practice globally. We implemented a cross-sectional, questionnaire-based survey among the OMF surgeons of India.

Objective:

The objectives of the study were (1) gathering data among the maxillofacial surgeons in terms of their occupational exposure and access to adequate personal protective equipment (PPE) and (2) to estimate how the COVID-19 pandemic has affected the practice of OMF surgeons in India.

Materials and Methods:

Complete responses of 178 OMF surgeons were included in the study. Descriptive and analytic statistics were computed. The level of statistical significance was set at P < 0.05. Binary logistic regression models were created to assess the predictors of the impact of the COVID-19.

Results:

Out of the 178 respondents of the study, most (37.1%) were following their hospital's guidelines. Most had access to adequate PPE (89.9%), whereas 93.8% had COVID-19 testing available. One hundred and thirty-three (74.7%) surgeons were involved in teleconsultation. Ninety-two (51.7%) and 166 (93.3%) were involved in elective surgery and emergency surgeries, respectively. Median outpatient department cases and number of surgeries done per week reduced by 73.9% and 66.7% (P < 0.001), respectively. Most surgeons (86%) experienced that cost of treatment had increased during the COVID. Over 75% were afraid to get infected with COVID, whereas 44.9% were anxious to lose the income. More than 56% of the OMF surgeons reported a fall in income and 94% reported decreased productivity in academic research. Most surgeons (93.8%) believed that COVID had a positive impact on human behavior in terms of hand hygiene.

Conclusion:

The impact of COVID-19 among OMF surgeons has adversely affected clinical practice, personal lives, and academic productivity and has catalyzed an exponential increase of telemedicine. Future surveys should capture the long-term impact of COVID-19.
Diagnostic significance of serum and salivary lipid levels in oral precancer and oral cancer
Authors: Singh Vandana , Patil Ranjitkumar , Singh Subash , Tripathi Anurag , Khanna Vikram , Ali Wahid
Published: July 2021

Introduction:

Lipids are one of the major constituents of the cell. Variations in the serum lipids have been considered a cofactor of carcinogenesis, as lipids play a crucial role in cell integrity. Saliva is an ultrafiltrate of plasma and correlates with the serum, which may be used as an alternate method of serum lipid level estimation. The study was conducted to find any correlation between serum and salivary lipid levels and to evaluate the changes in serum and salivary lipid levels in oral precancer and cancer patients.

Aims and Objectives:

This study aimed to evaluate the changes in serum and salivary lipid levels in oral precancer and cancer patients and to correlate salivary lipid levels with serum lipid levels.

Materials and Methods:

The study was an in vivo study conducted on randomly selected 129 patients with oral cancer and oral precancer. The selected subjects were divided into four groups as Group 1 – healthy control, Group 2 – oral submucous fibrosis, Group 3 – leukoplakia, and Group 4 – oral cancer. Serum and salivary lipid levels were estimated biochemically and statistically analyzed for any correlation with oral precancer and cancer.

Results:

Lipid level estimation showed no statistically significant difference on comparison of intergroup serum and saliva total cholesterol level and high-density lipoproteins among all four groups, whereas intergroup comparison of serum and saliva triglycerides (TG) levels among the four groups showed a statistically significant difference in saliva TG level. The correlation of serum and salivary lipid levels showed a significant positive correlation.

Conclusion:

In the present study association between serum/salivary lipid levels and oral precancer and oral cancer could not be established. A positive association was there in serum and salivary lipids hence salivary lipid levels may be used as a noninvasive technique for serum lipid level estimation.
Role of cartilage correcting sutures in single-stage secondary rhinoplasty for unilateral cleft lip nose deformity
Authors: Sharma Sunil , Dhull Kshiteej , Yadav Archana Jai Singh
Published: July 2021

Introduction:

The purpose of this study is to highlight the role of cartilage correcting suture in single-stage surgical correction for secondary unilateral cleft lip nose deformity with three-dimensional observations of preoperative and postoperative nasal forms.

Material and Methods:

Between July 2017 and June 2019, 18 consecutive patients of unilateral cleft lip nose deformity aged between 16 and 28 years underwent surgical correction. The corrective procedure of nose involved columellar lengthening, medial and lateral nasal osteotomies along with augmentation of premaxilla by bone graft at premaxilla, and alar base wedge resections. Focus was laid to correct nasal cartilaginous framework using tip sutures along with repositioning of lower lateral cartilages, fixation of the alar cartilage complex to the septum, and the upper lateral cartilages. We investigated the following surgical interventions and nasal tip suture techniques, which were transdomal suture, interdomal suture, lateral crural mattress suture, columella septal suture, and intercrural suture.

Results:

We achieved adequate esthetic and functional results in all the patients without any morbidity.

Conclusion:

This concept of simultaneous approach toward complete single-stage correction of secondary cleft lip nasal deformity incorporating various cartilage suture using 5-0 nylon in developing nation like ours, where the patient presents late with complex conditions showed promising esthetic and functional outcome.
Late-onset inverse Bell's phenomenon after upper eyelid trauma
Authors: Liakopoulos Dimitrios A. , Bontzos Georgios , Detorakis Efstathios T.
Published: July 2021

Bell's phenomenon evaluation is an important part of preoperative patient assessment for eyelid surgeries. Inverse Bell's phenomenon is a rare manifestation, usually observed in the early postoperative period following ptosis restoration surgeries, in pathological conditions, and in a small proportion of normal population. In the current case report, a 6-year-old girl presented with late-onset posttraumatic inverse Bell's phenomenon, 6 months after facial trauma with posttraumatic lagophthalmos. Rehabilitative blepharoplasty for the correction of lagophthalmos led to the restoration of inverse Bell's phenomenon 3 months postoperatively. Potential causative mechanisms are discussed for this late-onset manifestation of inverse Bell's response.
Guide flange Prosthesis for management of hemimandibulectomy
Authors: Bandodkar Siddharth , Arya Deeksha , Singh Saumyendra Vikram , Chand Pooran
Published: July 2021

Guide flange is given to patients who have undergone surgical hemi/segmental/subtotal mandibulectomy due to various reasons (leading cause being squamous cell carcinoma), with resultant mandibular deviation. If procedures such as secondary osseous grafting are planned, the clinician has to wait for healing of the graft, lesion, or radiotherapeutic effects to abate. Only after the healing of the graft, a definitive prosthesis can be planned. During this time lag, prosthesis must be given to the patient to correct mandibular deviation on account of unilateral muscle pull. Furthermore, in certain cases, a definitive prosthesis has to be put on hold due to failure of bone grafting or when the patient is not willing for a second surgery. This report describes the fabrication of such a mandibular guide flange prosthesis.
Management of a case of osteoma of coronoid
Authors: Saikrishna D. , Das Asutosh , Jha Chhaya
Published: July 2021

Coronoid process osteoma is an extremely unusual and slow growing tumor which causes functional limitations of the temporomandibular joint. Till december 2014 only 7 cases have been reported worldwide. This case report is about a 40 year old male patient with osteoma of left coronoid process. Treatment plan constitutes of surgical resection of the mass and post operative physiotherapy.
A clinical comparative study of dexmedetomidine as an adjuvant to 2% plain lignocaine and 2% lignocaine with 1
Authors: Nalawade Shubhada Harishchandra , Nilesh Kumar , Kumar C. D. Mounesh , Punde Prashant A , Patil Pankaj B
Published: July 2021

Introduction:

Dexmedetomidine is a selective alpha-2 adrenoceptor agonist. It is conventionally used as a sedative in the intensive care unit. However, recently, the application of dexmedetomidine as an adjuvant to a local anesthetic agent has been studied. The present study intends to evaluate the effectiveness of dexmedetomidine as an adjuvant to 2% plain lignocaine for surgical removal of impacted mandibular third molar and to compare the efficacy of dexmedetomidine with 2% plain lignocaine with 2% lignocaine and 1:200000 adrenaline.

Materials and Methods:

A total of 80 patients who required surgical removal of impacted mandibular third molar extraction were included in the study. Patients were randomly divided into two groups using a computer-generated table. Patients in the study group received 2% plain lignocaine with 1 mcg/ml dexmedetomidine. Patients in the control group received 2% lignocaine with 1:200000 adrenaline. The parameters evaluated were onset and duration of action, pulse rate, blood pressure, oxygen saturation, and blood loss.

Results:

Onset of action was faster and the duration of action was longer when dexmedetomidine was used with lignocaine as a local anesthetic agent. The vital parameters in both the groups were stable. Bleeding at the surgical site was less in the dexmedetomidine group.

Conclusion:

The study concluded that the combination of dexmedetomidine with lignocaine enhances the local anesthetic potency of lignocaine when injected for nerve blocks.
Psychiatric comorbidity and quality of life in patients with epilepsy on anti-epileptic monotherapy and polytherapy
Authors: Yadav Jagriti , Singh Priti , Dabla Surekha , Gupta Rajiv
Published: July 2021

Objective:

The bio-psycho-social factors affecting the quality of life in patients with epilepsy can be numerous but are often overlooked. The behavioral side effects of anti-seizure medications can be one such potential factor. The aim of the study is to address the effect of the number of anti-seizure medications on the development of psychiatric comorbidity and quality of life in patients with adequate seizure control.

Materials and Methods:

The study recruited 100 participants with generalized tonic-clonic seizures from a tertiary care center in North India, who were seizure-free from the last 1 month. The study participants were divided into two groups based on whether they were on monotherapy or polytherapy. The two groups were matched for their socio-demographic and clinical profile. We assessed for psychiatric comorbidity in each group using Mini International Neuropsychiatric Interview. All the study participants were given Hindi translated version of quality of life in the epilepsy-31 questionnaire for objective assessment of the quality of life.

Results:

The patients receiving anti-epileptic polytherapy had significantly higher prevalence of psychiatric comorbidity than patients on monotherapy. Furthermore, the patients on polytherapy scored significantly less on the cognitive domain of quality of life as well as the overall quality of life domain in the epilepsy-31 questionnaire.

Conclusion:

The patients with epilepsy must be evaluated for psychiatric comorbidity and side effect profile of anti-seizure medications to improve the quality of life. This is particularly more important for patients who are on anti-epileptic polytherapy even if the seizure control is adequate.
Plasma Circulating Tumor DNA in Patients with Primary Central Nervous System Lymphoma
Authors: Yoon Sang Eun , Kim Yeon Jeong , Shim Joon Ho , Park Donghyun , Cho Junhun , Ko Young Hyeh , Park Woong-Yang , Mun Yeung-Chul , Lee Kyoung Eun , Cho Duck , Kim Won Seog , Kim Seok Jin
Published: July 2021

PurposeAnalysis of circulating tumor DNA (ctDNA) in blood could allow noninvasive genetic analysis of primary tumors. Although there have been unmet needs for noninvasive methods in patients with primary central nervous system lymphoma (PCNSL), it is still not determined whether plasma ctDNA analysis could be useful for patients with PCNSL. Materials and MethodsTargeted deep sequencing of 54 genes was performed in cell-free DNA isolated from plasma samples collected pretreatment, during treatment, and at the end of treatment in 42 consecutively diagnosed PCNSL patients between January 2017 and December 2018.ResultsTargeted sequencing of plasma cell-free DNA detected somatic mutations representing ctDNA in 11 cases (11/41, 27%). The detection of ctDNA was not related to the concentration of cell-free DNA or tumor volume. The mutation profiles of these 11 cases varied between patients. The most frequently mutated gene was PIM1 (4/11, 36.4%), whereas KMT2D, PIK3CA, and MYD88 were each observed in three patients (3/11, 27%). The mutations of 13 genes were concordantly found in primary tumor tissue and plasma ctDNA, giving a detection sensitivity of 45%. During the serial tracking of seven patients with complete response, the disappearance of ctDNA mutations was found in four patients, whereas three patients had detected ctDNA mutation at the end of treatment. ConclusionThe plasma ctDNA mutation analysis still has limited value for surveillance and predicting treatment outcomes of PCNSL because the detection efficiency was lower than other systemic lymphomas. Thus, analytical platforms should be improved to overcome anatomical hurdles associated with PCNSL.
Entropy and finiteness of groups with acylindrical splittings
Authors: Cerocchi Filippo , Sambusetti Andrea
Published: July 2021

We prove that there exists a positive, explicit function

F(k, E)

such that, for any group

G

admitting a

k

-acylindrical splitting and any generating set

S

of

G

with

\operatorname{Ent}(G,S)

, we have

|S| \leq F(k, E)

. We deduce corresponding finiteness results for classes of groups possessing acylindrical splittings and acting geometrically with bounded entropy: for instance,

D

-quasiconvex

k

-malnormal amalgamated products acting on

\delta

-hyperbolic spaces or on

\operatorname{CAT}(0)

-spaces with entropy bounded by

E

. A number of finiteness results for interesting families of Riemannian or metric spaces with bounded entropy and diameter also follow: Riemannian 2-orbifolds, non-geometric

3

-manifolds, higher dimensional graph manifolds and cusp-decomposable manifolds, ramified coverings and, more generally,

\operatorname{CAT}(0)

-groups with negatively curved splittings.
Antonio Banfi in njegova smer v sodobni glasbeni estetiki
Authors: Antoni Luisa
Published: July 2021

Italijanski filozof Antonio Banfi (1886-1957) se je v prvi polovici 20. stoletja ukvarjal z raziskovanjem estetike in je v 20. in 30. letih na milanski Univerzi oblikoval svojo šolo razmišljanja. Banfi je vezna točka med evropsko tradicijo ter vplivi Kanta in Hegla po eni strani, po drugi pa strelovod za nove, inovativne misli, ki so preplavljale Evropo (Simmel, Dessoir, Valéry in predvsem Husserl). V članku avtorica nakazuje glavne smernice njegove estetike in zasleduje, kako so te smernice vplivale na oblikovanje italijanske glasbene estetike.
Contribution of Czech Musicians to the Serbian Music in the 19th Century
Authors: Tomašević Katarina
Published: July 2021

The main goal of this paper, devoted to the contribution of Czech Musicians to the Serbian Music in the 19th Century is to point out the facts which will contribute to the better understanding of the migration as an important cultural phenomenon. Particular attention will be paid to several musicians whose biographies and achievements are notable.
The Transcription of the Correspondence between Leoš Janáček (1854-1928) and Emerik Beran (1868-1940)
Authors: Weiss Jernej
Published: July 2021

Among the twenty-one preserved letters from Janáček to Beran, written during 1890 and 1928 in Czech, eight of Janáček’s letters and eight of Janáček’s postcards have been preserved, in addition to five official letters written during Beran’s pedagogical work at the Organ School in Brno. Among twenty-one of Beran’s letters to Janáček, written during 1914 and 1928 also in Czech, we can find eight of Beran’s letters and thirteen of Beran’s postcards, where in three of them, the place or time are not exactly given.
Reflections on the History of Computer-Assisted Music Analysis II: The 1960s
Authors: Schüler Nico
Published: July 2021

This article, the second in a series of articles on the history of computer-assisted music analysis, focuses on developments of computer-assisted music analysis during the 1960s. While the most trendsetting approaches and publications are being discussed, this article points out that at least up to the end of the 1960s, computer-assisted analysis of style was anything but comprehensive, interpersonal, and rich in musical insight. Nevertheless, the wealth of attempts to analyze music with the help of computers during the 1960s provided the foundation for the deeper approaches to computer-assisted music analysis of the following decades.
Palimpsestna struktura skladbe Tallis Petra Ruzicke ali v kolikšni meri je postmodernizem odvisen od modernizma
Authors: Pompe Gregor
Published: July 2021

Članek skuša razložiti naravo odnosa med modernizmom in postmodernizmom, pri čemer izpostavlja tisto možnost, po kateri gre v postmodernizmu za nadaljevanje in radikalizacijo modernizma. Ta teza je ilustrirana na primeru simfoničnega dela Tallis Petra Ruzicke, ki je zasnovano kot palimpsest.
Repertoar samospeva na Slovenskem ali/in slovenskega samospeva 19. stol. v fonoteki–glasbenem arhivu Radia Slovenija in njegovi izvajalci
Authors: Križnar Franc
Published: July 2021

Članek prinaša podroben pregled in analizo arhivskega zvočnega gradiva povezanega s slovensko ustvarjalnostjo 19. stoletja v zvrsti samospeva, kakor je zastopana v arhivih slovenske nacionalne Radiotelevizije. S tem pomembno osvetljuje recepcijo te ustvarjalnosti v drugi polovici 20. stoletja.
Romantičnost slovenskega »romantičnega« samospeva
Authors: Nagode Aleš
Published: July 2021

Avtor se posveča upravičenosti uporabe besedne zveze »romantični samospev« kot oznake za slovensko ustvarjanje 19. stoletja v tej zvrsti. Svoje opazovanje izpeljuje iz dveh možnih razumevanj pojma »romantika«: 1. kot oznake za glasbeno ustvarjalnost med leti 1820 in 1850; in kot oznake za del glasbene ustvarjalnosti 19. stoletja, zaznamovan z estetsko idejo »romantične presežnosti«, ki se kaže v poudarjenem preseganju dotedanjih vsebinskih in oblikovnih omejitev.
Josip Procházka (1874–1956) kot »češko-slovenski« skladatelj samospevov
Authors: Weiss Jernej
Published: July 2021

Avtor pričujočega prispevka skuša s primerjalno analizo določiti bistvene kompozicijsko-tehnične značilnosti in estetske usmeritve v enajstih samospevih Josipa Procházke, objavljenih v reviji Novi akordi, ki jih je skladatelj napisal za časa njegovega glasbeno-pedagoškega delovanja na Slovenskem. V želji po določitvi vloge in pomena omenjenih samospevov v širšem ustvarjalnem kontekstu samospeva na Slovenskem pa se avtor pričujočega prispevka kritično opredeli do razumevanja napredka v funkciji utrjevanja nacionalne samobitnosti, ki je zdi se pomembno zarisalo meje uredniški politiki v navidez »zunajstrankarski« reviji Novi akordi.
A Fragment to the Genre of the Piano Piece: Its ‘Real’ Beginning in the Slovene Musical Literature?
Authors: Bogunović Hočevar Katarina
Published: July 2021

In spite of its small quantity, in its own way the piano opus of Janko Ravnik marked the history of Slovene piano music. Particularly with his early piano works, Ravnik opened up new dimensions in Slovene pianistic creativity. Addressing question as to whether we can speak of his piano compositions as the beginning of the piano piece in Slovenia, the present article seeks an answer on two levels: the compositional-technical and reception.
Serbian Romantic Lied as Intersection of the Austro-Hungarian and Serbian (con)texts
Authors: Marković Tatjana
Published: July 2021

The authoress focuses on detecting Viennese cultural influences of the second half of the 19th century upon the composing of Josif Marinković’s solo song, the culture in which he educated himself, and on revealing elements characteristic of Serbian culture within which he composed.
Türkiye’de ve Dünyada Kadın Sağlığı Hemşireliği
Authors: KARAKUT Şerivan , KABALCIOĞLU BUCAK Feray
Published: July 2021

Nursing, as a community service, is a profession that has existed since ancient times, with the desire to make people healthy, to ensure the comfort of people, to take care of the patient and to provide the patient with a sense of safety. Due to the impact of technology on healthcare, and with the increase in knowledge, many nurses today are seeking to work in an expanding, specialized or advanced practitioner role. Women's health nursing undertakes the roles of education, counseling, evidence-based work, research and scientific knowledge production, reducing the cost of care and increasing community satisfaction, with a woman-centered holistic approach at each life stage of women, in order to prevent diseases, and to protect and improve health. In developed countries in the field of Women's Health Nursing, such as the USA, England and Thailand, women's health nursing is a very special field of advanced nursing practices, which provides a woman-centered holistic approach, in the delivery of primary healthcare services, requiring master or PhD level expertise, and has dynamic&highly autonomous roles. Considering the developing countries, it is seen that women's health nursing is not really developed and it is carried out under the name of community-based nursing or "midwifery" in these countries. In 2011, women's health nursing roles and responsibilities were announced in our country, but its special fields were not included. In this context, it is necessary to develop special fields such as urogynecology, infertility, perinatology, gynecology and gynecological oncology, sexual health, menopause, as well as reorganize the roles and responsibilities of specialist nurses and all these should be supported within the scope of legal regulation.
Stabil Angina Pektorisli Hastalarda Arteriyel Sertlik Ve Aort Augmentasyon İndeksinin Koroner Arter Hastalığı İle İlişkisi
Authors: UYSAL Ali , ÇALIŞKAN Serhat , GÜNAY Şeyda , ATAY Mehmet , SERDAR Osman Akın
Published: July 2021

Objective : Many studies have indicated arterial stiffness as an independent predictor of hypertension, stroke, cardiovascular events, and mortality. However, the relationship between the severity of coronary artery disease(CAD) and arterial stiffness is still unclear. In this study, it was aimed to examine the relationship between augmentation index which is a marker of arterial stiffness with CAD and its prevalence. Methods: A total of 80 patients (22 women, mean age 59±8) who were scheduled for coronary angiography with a preliminary diagnosis of coronary artery disease by evaluating their symptoms and findings and coronary risk profiles were included. The other group have 20 healthy patients without any chronic disease history. The augmentation index (AIX), which is an indicator of arterial stiffness, was measured in all cases with the BP+ Central Blood Pressure CardioScope II device in all groups. Gensini score of the patient group was calculated. Results: It was found to be 131% (79-198mmHg) in the AIX patient group and 72.5% (69-96mmHg) in the control group (p<0.001). A positive correlation was observed between AIX and Gensini score, LDL-cholesterol, body mass index and HbA1c in the patient group. In the ROC analysis, the area under the curve (AUC) for AIX was calculated as 0.701 (P<0.001). While AIX was 121% above normal, it predicted coronary artery disease with 94.8% sensitivity and 80.9% specificity. Conclusion: In our study, a relationship was found between coronary artery disease with its severity and arterial stiffness. Augmentation index can be used effectively with low cost in predicting coronary artery disease.
Analisis Implementasi Media Komunikasi Berbasis IP Menggunakan Arterisk Freepbx
Authors: Ramadhan Bagoes , Fatchan Muhamad , Rilvani Elkin
Published: July 2021

Voice over Internet Protocol (VoIP) merupakan teknologi yang memanfaatkan Internet Protocol untuk menyediakan komunikasi voice secara elektronis dan real-time. Unsur pembentuk VoIP adalah User agent, Proxy, Protocol dan Coder-Decoder (CODEC). Asterisk merupakan softswicth untuk mengoperasikan proxy, yang berbasis session initiation protocol (SIP). Tujuan dari penelitian ini adalah membangun server VoIP berbasis Asterisk, agar dapat dikembangkan pada penelitian selanjutnya sesuai dengan kebutuhan. Penelitian ini dilakukan pada instalasi yang sudah dibangun jaringan internet sebelumnya. Sehingga VoIP disini difungsikan sebagai pemaksimalan jaringan internet yang sudah ada tersebut untuk menekan biaya pengeluaran kebutuhan komunikasi. Layanan yang disediakan pada penelitian ini berbentuk voice dan video dengan layanan call client to server, call client to client, video call conference, video conference.
PENGARUH KEPERCAYAAN MEREK, KESADARAN MEREK DAN KUALITAS PRODUK TERHADAP KEPUTUSAN PEMBELIAN SMARTPHONE XIAOMI DI DIY
Authors: Khoirudin Isnan Rizki , Giyartiningrum Eko
Published: July 2021

This study aims to determine the effect of brand trust, brand awareness and product quality on purchasing decisions for Xiaomi smartphones for all consumers of Xiaomi smartphone users in Yogyakarta. The population used in this study were all consumers who use Xiaomi smartphones in Yogyakarta, with a sample of 100 respondents. The sampling technique used nonprobability sampling with a purposive sampling approach. The data collection technique used a questionnaire. The data analysis method used is multiple linear regression analysis, classical assumption test, hypothesis testing. The results of this study indicate that brand trust and product quality partially influence purchasing decisions. Brand trust, brand awareness and product quality simultaneously influence purchasing decisions.
PENGARUH MOTIVASI DAN KOMITMEN TERHADAP PRESTASI KERJA PEGAWAI DINAS PERIZINAN DAN PENANAMAN MODAL DAERAH ISTIMEWA YOGYAKARTA (DPPM DIY)
Authors: Juanita Savera Mahenina , Subiyanto Didik , Kurniawan Ignatius Soni
Published: July 2021

This study aims to determine the effect of motivation and commitment on employee work performance. This type of research used in this research is quantitative research. The population in this study were all employees of the Yogyakarta Special Region Licensing and Investment Service (DPPM DIY), both permanent and contractual. The number of samples taken in this study were 50 employees. The results of this study indicate that the effect of motivation has a positive and significant effect on work performance, commitment has a positive and significant effect on work performance, and motivation and commitment have a positive and significant effect on work performance of the employees of the Licensing and Investment Service of the Special Region of Yogyakarta (DPPM DIY).
KEPUTUSAN PEMBELIAN MAHASISWA PADA PRODUK ONLINE SHOP SHOPEE DAN FAKTOR PENENTUNYA
Authors: Ependi Heru , Pahlevi Reza Widhar
Published: July 2021

Abstract

The purpose of this study is to find out what factors determine online consumer purchasing decisions at Shopee and how the online consumer purchasing decisions process at Shopee. The research approach used is a qualitative descriptive approach. Research related to consumer online purchasing decision factors at Shopee, the object to be studied is consumers who use the Shopee application. In social situations or research objects, the object of this research is the students of the Faculty of Economics, Cokroaminoto University, Yogyakarta, who actively use the Shopee application as a place to shop online, and who are considered to meet or know the research criteria. Based on the results of the discussion that the promotions implemented in the Shopee e-commerce store, such as the application of discount promotions, free shipping promotions, prices, product quality and trust given by the Shopee company, affect consumers' online purchasing decisions at Shopee and then the online consumer decision process. preceded by, problem recognition, information search, evaluation of alternatives, purchase decisions, post-purchase behavior, influenced by many factors. These factors can be internal factors, namely consumer psychology, and external factors, which consist of the socio-cultural environment of the community, marketing stimuli, and vendor control systems which include time efficiency in seeking competitive prices and good quality.
Study of Strange Particle Production in Central Pb–Pb Collisions at
Authors:   Department of Physics, COMSATS University, Park Road, Islamabad 44000, Pakistan, A Arif , MQ Haseeb ,   Department of Physics, COMSATS University, Park Road, Islamabad 44000, Pakistan, MK Suleymanov ,   Department of Physics and Institute for Physical Problems, Baku State University, Z. Khalilov 23, Baku, Azerbijan
Published: July 2021

We study here the transverse momentum spectra of Ks 0 – mesons, A − hyperons and multi–strange (Ξ–, Ω–) particles in the most central Pb–Pb collisions at √SNN = 2.76 TeV for the mid rapidity interval |y| < 0.5 by using two different Monte Carlo simulation models: EPOS–1.99 and EPOS–LHC. The validity of simulation codes of these models is checked for Pb–Pb collisions at √SNN = 2.76 TeV by comparing the simulation data with ALICE experimental data for the same collisions at √SNN = 2.76 TeV. Strange particles ratio i.e. and nuclear modification factors for multi–strange particles have been constructed as function of pT to study these strange particle production and their energy loss mechanism. The simulation models show suppression for the multi–strange particles in the transverse momentum range of 3–7 GeV/c. The outcome agrees with a recent finding by ALICE collaboration where it suggested a possibility that the kinetic freeze–out conditions for strange particles are different from those for non–strange particles