bluuebunny/crossref_metadata_2025 huggingface dataset:
A Virtual Dual-Ripple Suppression Strategy of Double Fed Wind Turbine Under Wind Shear
Authors: Li Zhiyong , Pi Jiahua , Cao Yuan , Wang Xin
Published: October 2022

With the increasing size and scale of wind turbines, the ripple caused by wind shear may have negative effects on wind turbines, such as decreasing grid-connected power quality and increasing mechanical loss. To address this issue, a virtual dual-ripple suppression strategy is proposed to suppress the ripple caused by wind shear without additional cost and sacrificing system efficiency. First, in this paper, a three-bladed double-fed wind turbine is taken as the research object with the analysis of its transmission mechanism and form of ripple. Second, an online artificial neural network (ANN) ripple detection method is proposed to detect the time-varying low-frequency ripple with high accuracy. In addition, a virtual dual-ripple suppression strategy composed of two ANN-based filters is utilized to suppress electromagnetic torque ripple and grid-connected power ripple simultaneously. Finally, the accuracy of the presented ANN ripple detection method and suppression strategy are verified by matlab simulation. The results show that the virtual dual-ripple suppression strategy can effectively suppress the transmission of ripple while increasing the conversion efficiency of wind energy without additional hardware circuits and equipment.
Tribological and Friction-Induced Vibration Behaviors of Inorganic Fullerene-Like Tungsten Disulfide and Three-Dimensional Graphene as Lubricant Additives
Authors: Ouyang Tiancheng , Tang Wentao , Lei Wenwu , Cheng Liang
Published: October 2022

Friction and friction-induced vibration have a great impact on the service life of mechanical systems. In this study, the tribological performances and vibration characteristics of three-dimensional graphene nanosheets (3D GNS), inorganic fullerene-like tungsten disulfide (IF-WS2), and their mixed additive lubricants are investigated by experiments. The results show that IF-WS2/3D GNS (1:1) mixed additive can improve the friction-reduction and anti-wear of base oil by 62.9% and 71.4%, respectively. In terms of vibration damping, the mixed additive has an extremely strong dampening effect on vibration acceleration in all directions, especially in the Z-axis direction, where the amplitude is reduced by about 90%. The vibration damping should be attributed to the filling effect of 3D GNS and IF-WS2, which greatly flattens the friction surface, thus reducing the number of collision micro-bumps in the relative movement of the friction pair and suppressing the vibration. In addition, the unique ductile deformation of IF-WS2 makes the two additives form a flexible ball-bearing damper between the two contact surfaces, thus greatly reducing the vibration.
Perceptual detection thresholds for numerical dispersion in binaural auralizations of two acoustically different rooms
Authors: Meyer Julie , Lokki Tapio , Ahrens Jens
Published: October 2022

Room acoustic simulations using the finite-difference time-domain method on a wide frequency range can be computationally expensive and typically contain numerical dispersion. Numerical dispersion can be audible and, thus, constitutes an artifact in auralizations. There is a need to measure perceptual thresholds for numerical dispersion to achieve an optimal balance between computational complexity and audibility of dispersion. This work measures the perceptual detection thresholds for numerical dispersion in binaural auralizations of two acoustically different rooms. Numerical dispersion is incorporated into measured binaural room impulse responses (BRIRs) by the means of filters that represent the dispersion that plane waves experience, which propagate in the simulation in the direction of the worst-case dispersion error. The results show that the perceptual detection threshold is generally lower for the most reverberant room and greatly depends on the source signal independently of the room in which the threshold is measured. It is the most noticeable in the pure BRIRs, i.e., with an impulse as source signal, and almost unnoticeable with speech. The results also show that there was no statistical evidence that the perceptual thresholds for the conditions where numerical dispersion was present or absent in the direct path of the BRIRs be different.
Movement Regularity Differentiates Specialized and Nonspecialized Athletes in a Virtual Reality Soccer Header Task
Authors: Riehm Christopher D. , Bonnette Scott , Riley Michael A. , Diekfuss Jed A. , DiCesare Christopher A. , Schille Andrew , Kiefer Adam W. , Jayanthi Neeru A. , Kliethermes Stephanie , Lloyd Rhodri S. , Pombo Mathew W. , Myer Gregory D.
Published: October 2022

Background: Young athletes who specialize early in a single sport may subsequently be at increased risk of injury. While heightened injury risk has been theorized to be related to volume or length of exposure to a single sport, the development of unhealthy, homogenous movement patterns, and rigid neuromuscular control strategies may also be indicted. Unfortunately, traditional laboratory assessments have limited capability to expose such deficits due to the simplistic and constrained nature of laboratory measurement techniques and analyses. Methods: To overcome limitations of prior studies, the authors proposed a soccer-specific virtual reality header assessment to characterize the generalized movement regularity of 44 young female athletes relative to their degree of sport specialization (high vs low). Participants also completed a traditional drop vertical jump assessment. Results: During the virtual reality header assessment, significant differences in center of gravity sample entropy (a measure of movement regularity) were present between specialized (center of gravity sample entropy: mean = 0.08, SD = 0.02) and nonspecialized center of gravity sample entropy: mean = 0.10, SD = 0.03) groups. Specifically, specialized athletes exhibited more regular movement patterns during the soccer header than the nonspecialized athletes. However, no significant between-group differences were observed when comparing participants’ center of gravity time series data from the drop vertical jump assessment. Conclusions: This pattern of altered movement strategy indicates that realistic, sport-specific virtual reality assessments may be uniquely beneficial in exposing overly rigid movement patterns of individuals who engage in repeated sport specialized practice.
Preservice Physical Education Teacher Preparation for Health-Related Fitness Testing: A Faculty Perspective
Authors: Liu Xiaolu , Hamilton Xiaofen D. , Shangguan Rulan , Liu Jingwen , Wall Sarah J. , Guerra Richard
Published: October 2022

Purpose: This study aimed to examine how physical education teacher education (PETE) programs prepare preservice physical education teachers (PPETs) for implementing health-related fitness testing (HRFT) in K–12 schools from a faculty perspective. Methods: The study applied a phenomenological approach. Seven PETE faculty participated in this study. Data were collected through semistructured interviews, online surveys, and course documents. Constant content analysis was performed to generate themes. Results: The study discovered four themes: (a) required courses are the primary means for preparing PPETs to use HRFT, (b) cooperating teachers can negatively influence the faculty’s role in HRFT preparation, (c) PPETs explored the use of HRFT in PETE programs through peer teaching and testing activities, and (d) there was a lack of field-based experiences in local schools for HRFT preparation. Conclusion: PETE programs provided some courses to prepare PPETs for the HRFT implementation with the lack of time and field experience.
Sex matters in liver fat regulation
Authors: Waxman David J. , Kineman Rhonda D.
Published: October 2022

Growth hormone orchestrates a complex, sex-dependent balancing act
Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families
Authors: Reis-Cunha João Luís , Coqueiro-dos-Santos Anderson , Pimenta-Carvalho Samuel Alexandre , Marques Larissa Pinheiro , Rodrigues-Luiz Gabriela F. , Baptista Rodrigo P. , Almeida Laila Viana de , Honorato Nathan Ravi Medeiros , Lobo Francisco Pereira , Fraga Vanessa Gomes , Galvão Lucia Maria da Cunha , Bueno Lilian Lacerda , Fujiwara Ricardo Toshio , Cardoso Mariana Santos , Cerqueira Gustavo Coutinho , Bartholomeu Daniella C.
Published: October 2022

Sequences that have several copies in a genome, such as multicopy-gene families, mobile elements, and microsatellites, are among the most challenging genomic segments to study. They are frequently underestimated in genome assemblies, hampering the correct assessment of these important players in genome evolution and adaptation.
The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response
Authors: Roux Anne-Emmanuelle , Robert Sylvie , Bastat Mathilde , Rosinski-Chupin Isabelle , Rong Vanessa , Holbert Sébastien , Mereghetti Laurent , Camiade Emilie
Published: October 2022

Streptococcus agalactiae
is a major cause of disease burden leading to morbidity and mortality in neonates worldwide. Deciphering its adaptation mechanisms is essential to understand how this bacterium manages to colonize its host. Here, we determined the regulon of the pleiotropic regulator CcpA in
S. agalactiae
. Our findings reveal that CcpA is not only involved in carbon catabolite repression, but is also important for acidic and oxidative stress resistance and survival in macrophages.
First record of a least weasel in Nunavik
Authors: Fauteux Dominique
Published: October 2022

The spatial distributions of several small mammals in Nunavik, Québec, Canada, currently do not rely on any recorded observations due to the rarity of wildlife surveys in that area. This is concerning because understanding changes in wildlife populations in response to the rapidly warming Arctic requires knowledge of prior population states. On 18 July 2021, my assistant and I captured a least weasel ( Mustela nivalis Linnaeus, 1766) alive, 11 km southwest of Salluit during a live-trapping session of lemmings and voles. Identification was done with the small body mass (44 g), the presence of prominent testicles indicating maturity, short length of the tail, and pale colour at the tip of the tail. All these criteria combined fit only the description of least weasels. According to the available records for this species, this observation is the first one confirmed in Nunavik. This Low Arctic area was already included in the species distribution described in the literature, but no record supported it up to now. It is of particular importance considering this species is susceptible to be designated as threatened or vulnerable in the province of Quebec according to the Centre de données sur le patrimoine naturel du Québec.
A PROCESS-BASED FRAMEWORK AROUND “LIGHTHOUSE PROJECTS” FOR BUSINESS MODEL INNOVATION
Authors: BITETTI LEANDRO
Published: October 2022

Despite the extant literature studies on business model innovation in response to a single (rather than multiple) strategic goal, entrepreneurs mostly approach the business model innovation process as a portfolio of parallel initiatives and solutions to the problems that are to be implemented. In the VUCA (i.e., volatile, uncertain, complex, ambiguous) context, a problem-solving roadmap for business model innovation is particularly relevant. However, the process is far from being easy, and most research focusses on the organisational level of analysis. By building on the cognitive perspective of business model innovation, this study implements an action research methodology to develop a framework that aims to help entrepreneurs structure a business model innovation roadmap that entails the exploitation and exploration activities. The framework has three steps. The first step attempts to build consistency in the problems, strategic goals, and initiatives. The second clusters the initiatives around “Lighthouse Projects”. The last step establishes a timeline and an action plan.
CREATING BALANCING SPACES FOR DIGITAL AMBIDEXTERITY: IDENTIFYING DIVERGENCE AND COMPETING DEMANDS IN HEALTHCARE TRANSFORMATION INITIATIVES
Authors: JOHANSSON PETER E. , STEFAN IOANA , AXELSSON KARIN , SÖDERBERG TOBIAS , FORSBERG KATARINA
Published: October 2022

Digital transformation is crucial for the healthcare sector, yet research shows that it also possesses a series of challenges at system-, organisational-, and individual levels, which require balancing. In this study, we adopt paradox theory to understand the balancing practices and requirements for digitalisation in healthcare. Based on gaps in previous research and practice, this paper aims to explore what characterises the different kinds of tensions and organisational paradoxes related to digital transformation. Also, this paper discusses how balancing practices in digital transformation are constrained and enabled. The paper is based on a project run in co-production between researchers at the Mälardalen University and project partners at a healthcare Region in Sweden. In the findings, two kinds of tensions are identified in digital transformation initiatives: Divergence at different organisational levels and competing demands between past, present and future needs. The divergent views are characterised by being latent while the competing demands are characterised by being salient to the organisation. This is followed by a discussion about balancing practices enabling digital ambidexterity and spurring virtuous cycles.
Meta-population model about immigrants and natives with heterogeneity mixing and vaccine strategy of tuberculosis in China
Authors: Xu Chuanqing , Huang Xiaotong , Cui Jingan , Zhang Zonghao , Feng Yejuan , Cheng Kedeng
Published: October 2022

China is one of the countries in the world carrying a heavy burden of tuberculosis. Due to the unbalanced economic development, the number of people working in other parts of country is huge, and the mobility of personnel has exacerbated the increase in tuberculosis cases. Most patients affected by this are in their middle and young ages. It is having a great impact among the family and society. Therefore, research on how to control this disease is absolutely necessary. The population is divided into two categories such as local population and the immigrant population. A pulmonary tuberculosis dynamic model with population heterogeneity is established. We calculate the basic reproductive number and the controlled reproductive number, and discuss the two types of population under the constraints given by the amount of vaccine and the optimal immunization ratio obtained is [Formula: see text], which can reduce the effective reproduction number from 5.85 to 0.227. It is understood that immunizing the local population will control the spread of the epidemic to a large extent, and we simulate the final scale of infection after immunization under the optimal immunization ratio. It can take a minimum of at least 10 years to reduce the spread of this disease, but to eliminate it forever, it needs at least a minimum of 100 years.
Reliability at multiple stages in a data analysis pipeline
Authors: Moskovitch Yuval , Jagadish H. V.
Published: October 2022

Data-centric methods designed to increase end-to-end reliability of data-driven decision systems.
Simple Uncoupled No-regret Learning Dynamics for Extensive-form Correlated Equilibrium
Authors: Farina Gabriele , Celli Andrea , Marchesi Alberto , Gatti Nicola
Published: October 2022

The existence of simple uncoupled no-regret learning dynamics that converge to correlated equilibria in normal-form games is a celebrated result in the theory of multi-agent systems. Specifically, it has been known for more than 20 years that when all players seek to minimize their
internal
regret in a repeated normal-form game, the empirical frequency of play converges to a normal-form correlated equilibrium. Extensive-form (that is, tree-form) games generalize normal-form games by modeling both sequential and simultaneous moves, as well as imperfect information. Because of the sequential nature and presence of private information in the game, correlation in extensive-form games possesses significantly different properties than in normal-form games, many of which are still open research directions. Extensive-form correlated equilibrium (EFCE) has been proposed as the natural extensive-form counterpart to the classical notion of correlated equilibrium in normal-form games. Compared to the latter, the constraints that define the set of EFCEs are significantly more complex, as the correlation device (a.k.a. mediator) must take into account the evolution of beliefs of each player as they make observations throughout the game. Due to that significant added complexity, the existence of uncoupled learning dynamics leading to an EFCE has remained a challenging open research question for a long time. In this article, we settle that question by giving the first uncoupled no-regret dynamics that converge to the set of EFCEs in
n
-player general-sum extensive-form games with perfect recall. We show that each iterate can be computed in time polynomial in the size of the game tree, and that, when all players play repeatedly according to our learning dynamics, the empirical frequency of play after
T
game repetitions is proven to be a

\( O(1/\sqrt {T}) \)

-approximate EFCE with high probability, and an EFCE almost surely in the limit.
Applying the metaverse
Authors: Kirkpatrick Keith
Published: October 2022

Business, entertainment, and fashion companies already are staking their claims in this enhanced virtual world.
Transport Properties in Electrodes for Lithium-Ion Batteries: Comparison of Compact versus Porous NCM Particles
Authors: Schneider Luca , Klemens Julian , Herbst Eike Christian , Müller Marcus , Scharfer Philip , Schabel Wilhelm , Bauer Werner , Ehrenberg Helmut
Published: October 2022

Previous investigations on porous Li(NixCoyMnz)O2 (NCM) particles with shortened diffusion paths and an enlarged interface between active material and electrolyte show improved rate capability and cycle stability compared to compact particles. Due to the additional intragranular porosity of the active material, also the pore structure of the overall electrode, and as consequence, the ionic transport in the pore phase is altered. In addition, the particle morphology influences the ohmic contact resistance between the current collector and electrode film. These effects are investigated using impedance spectroscopy in symmetrical cells under blocking conditions. The ionic resistance and the tortuosity of the electrodes are determined and analyzed by a transmission line model. Tortuosity is higher for porous particles and increases more during calendering. This limits the options to densify these electrodes to the same level as with compact particles. In a further approach, the method is used to explain the drying related performance differences of these electrodes. At higher drying rates, the contact and the ionic resistance of electrodes with compact particles increases more strongly as for electrodes with porous particles. These investigations provide new insights into the ion transport behavior and enable a better understanding of the impact of the electrode processing condition.
Grade-focused interactions in higher education: has the pursuit for good grades replaced learning?
Authors: Horne Andrew , Yuen Jenna J. , Beveridge Tyler S. , McLean Sarah
Published: October 2022

Undergraduate science students face immense pressure to perform academically; this pressure may be linked to grade-focused interactions, which have been anecdotally reported among educators. This study evaluated the prevalence of and motivations underlying this behavior. One-quarter of our study participants self-reported negotiating a grade. The vast majority of respondents perceived that they lost grades (rather than earned them); an intervention to change this “grade loss” mentality failed to have any impact on students’ behavior.
Ultrasound imaging in teaching cardiovascular physiology: disruption and challenge to foster learning
Authors: Roe Sean M. , Tansey Etain A. , Johnson Christopher D.
Published: October 2022

This work compares learning in cardiovascular physiology classes enhanced by using cheap ultrasound equipment with learning in comparable control classes without ultrasound. Performance improvement in single best answer tests between pre- and postclass tests were compared for the ultrasound and control classes, with little difference shown between the two classes. We question whether it is appropriate to measure deep learning after 2-h classes or whether other, phenomenological, qualitative measures of educational effectiveness would be better.
Generation Mechanism and Characteristic Analysis of Dual-Frequency Pseudo-Signal Interference of the Swept-Frequency Radar
Authors: Zhao Hong-Ze , Wei Guang-Hui , Pan Xiao-Dong , Du Xue , Lyu Xu-Xu
Published: October 2022

In order to master the law of the pseudo-signal interference effect of dual-frequency electromagnetic radiation in typical radar equipment, a certain type of Ku-band swept-frequency ranging radar was used as the test object to carry out single-frequency continuous wave and dual-frequency continuous wave pseudo-signal interference effect experiments. Through experiments, it is found that dual-frequency electromagnetic radiation will cause “hill” and “spike” type pseudo-signal interference to the swept-frequency radar. Based on the frequency analysis of the radar receiving circuit, the interference mechanism of the dual-frequency pseudo-signal is revealed, and the morphological characteristics and distance law of the pseudo-signal are explained. The variation law of the pseudo-signal level with interference field strength is obtained. The results show that the in-band dual-frequency nonintermodulation interference is similar to the single-frequency interference, and the only difference is that the number of pseudo-signals increases; when the interference frequency difference is about 400∼600 MHz, the out-of-band dual-frequency second-order intermodulation signal will cause “hill” type pseudo-signal interference, and the pseudo-signal distance is random; when the interference frequency difference is less than 5 MHz, both the dual-frequency second-order intermodulation signal and the third-order intermodulation signal will cause “spike” pseudo-signal interference inside and outside the radar operating frequency band; the pseudo-signal distance is fixed.
The Evaluation for Salvinia sp. Adaptation to Iron Concentration on Nutrient Solution and Tidal Swamplands Soil Growing Media
Authors: Lubis Iskandar , Noor Aidi , Ningsih Rina Dirgahayu , Anwar Khairil , Ghulamahdi Munif , Wirnas Desta
Published: October 2022

Salvinia sp. is an alternative aquatic plant that is abundant in the swamplands and can be used for bioremediation of water contaminated with metals. The objectives of the experiment were (1) to evaluate the adaptation of Salvinia sp. to the iron (Fe) concentration in nutrient solution and tidal swampland soil growing medium and (2) to obtain Fe-adaptive Salvinia sp. as indicated by having rapid growth and high biomass. The experiment has been carried out in Cikabayan greenhouse IPB University, Bogor. Salvinia sp. was evaluated in a 4-liter plastic container with Hoagland nutrient solution that was supplemented with Fe based on the experimental treatments. The 10 accessions of Salvinia sp. were selected and evaluated using a pot filled with soil from tidal swampland. The results showed that increasing Fe concentration from 7 to 14 ppm in solution inhibited the growth, reduced the fresh weight, and delayed the doubling time of Salvinia sp. The selection of Salvinia sp. on 7 ppm Fe obtained 4 Salvinia sp. accessions with high biomass weights and fast doubling time, namely S. Kambat, Murung Karamat, Gambut, and Muning Tengah. Among the 4 accessions, the best two were S. Kambat and Murung Karamat with a fast doubling time of about 7.9 days and were adaptive in the tidal swampland.
Accurate Empirical Path Loss Models with Route Classification for mmWave Communications
Authors: Phaiboon Supachai , Phokharatkul Pisit
Published: October 2022

This paper presents accurate empirical path loss models with route classification for the high band frequency of 5 G wireless. Propagation path routes are mainly classified into line of sight (LOS) and non-line-of-sight (NLOS). The NLOS routes are classified into 2 separate routes, namely, Hard_NLOS and Soft_NLOS. Their path loss models include free-space loss (Lfs) and multiscreen diffraction loss (Lmsd) together with the reflection from the building blocks. However, these NLOS routes can be combined into a single formula. The path loss models were fitted with measured path loss data at frequencies of 28 GHz and 73 GHz. These models are compared with four 5G empirical models, namely 5GCM, 3GPP, METIS, and mmMAGIC. The results show that the separated route models provide good agreement, especially for the hard routes compared with those models and provide the minimum MAE of 4.45 dB, 4.34 dB, and 6.72 dB for the hard route, soft route, and an all-NLOS route, respectively, for the dual-band frequency.
Rab7 Investigation Insights into the Existence of White Spot Syndrome Virus in Crustaceans: An In Silico Approach
Authors: Hasan Mehedi Mahmudul , Hoque M. Nazmul , Hasan Md Robiul , Asaduzzaman Mohammad , Juliana Farha Matin
Published: October 2022

In this study, previously published Rab7 sequences from National Center for Biotechnology Information (NCBI) have been investigated from chordates, mollusks, annelids, cnidarians, amphibians, priapulids, brachiopods, and arthropods including decapods and other groups. Among decapod crustacean isolates, amino acid variations were found in 13 locations. Penaeid shrimps had variations in positions 13 (I ⟶ J), 22 (T ⟶ A), 124 (G ⟶ X), and 149 (V ⟶ X) while interestingly the freshwater prawn and mitten crab both had amino acid substitutions in positions 87 (V ⟶ C) and 95 (T ⟶ S) along with the other disagreements in amino acid positions 178 (S ⟶ N), 201 (D ⟶ E), 181 (E ⟶ D), 182 (L ⟶ I), 183 (Y ⟶ G), 184 (N ⟶ H), and 198 (A ⟶ T). Among 100 isolates of Rab7 from organisms of various phyla, mutations were observed in several positions. These mutations caused variations in hydrophobicity and isoelectric point which impact the ligand-protein binding affinity. Some common mutations were found in the organisms of the same phylum and among different phyla. Homology modeling of Rab7 proteins from different organisms was done using SWISS-MODEL and validated further by developing Ramachandran plots. Protein-protein docking showed that active residues were there in the binding interfaces of Rab7 from organisms of seven different phyla and VP28 of WSSV. Similarities were observed in the Rab7-VP28 complexes in those selected organisms which differed from the Rab7-VP28 complex in the case of Penaeid shrimp. The findings of this study suggest that WSSV may exist in different marine organisms that have Rab7 protein and transmit to crustaceans like shrimps and crabs which are of commercial importance.
Numerical Study on Effects of Arrayed Pulsed Energy Depositions on a Supersonic Combustor
Authors: Cai Zilin , Gao Feng , Wang Hongyu , Ma Cenrui
Published: October 2022

This paper proposes a method to improve the mixing efficiency of a supersonic combustor by using arrayed pulsed energy depositions, and this method is verified by a numerical simulation. In the simulation, the Navier-Stokes equations with an energy source are solved to simulate the effects of energy depositions in various distributions on the fuel mixture in the combustor. It is found that the energy deposition arranged in the streamwise direction leads to a significant improvement in the mixing efficiency and maximum concentration decay rate of the ethylene fuel by increasing the scale of the jet-induced counter-rotating vortex pair. The energy deposition arranged in the spanwise direction introduces another counter-rotating vortex pair which can also contribute to the fuel mixture. By comparison, the energy deposition distributed in the streamwise direction and downstream of the jet orifice is shown to be the most effective case in the fuel mixing enhancement. Under the energy deposition, the wall pressure on the trailing edge of the cavity is increased which leads to a decrease in the total pressure recovery of the combustor, but this decrease is not significant.
Mixed

ℋ

∞

and Passivity Analysis of Delayed Fractional-Order Complex Dynamical Networks with Hybrid Coupling
Authors: Alsulami Hamed , Syed Ali M. , Hymavathi M. , Saeed Tareq , Ahmad Bashir , Alsaedi Ahmed
Published: October 2022

In this article, global asymptotic stability analysis, and mixed

ℋ

∞

and passive control for a class of control fractional-order systems is investigated. Based on the fractional-order Lyapunov stability theorem and some properties of fractional calculus, we propose sufficient conditions to ensure the mixed

ℋ

∞

and passivity performance. More relaxed conditions by employing the new type of augmented matrices by using Kronecker product terms can be handled, which can be introduced. The derived criteria are expressed in terms of linear matrix inequalities that which can be checked numerically using toolbox MATLAB. Finally, two numerical examples are provided to demonstrate the correctness of the proposed results.
Bioinformatics Analysis of Common Genetic and Molecular Traits and Association of Portal Hypertension with Pulmonary Hypertension
Authors: Chen MingYu , Chen YouPeng
Published: October 2022

Portal hypertension (PH) is an important cause of pulmonary arterial hypertension(PAH), but its mechanism is still unclear. We used genetic data analysis to explore the shared genes and molecular mechanisms of PH and PAH. We downloaded the PH and PAH data from the GEO database, and used the weighted gene coexpression network analysis method (WGCNA) to analyze the coexpression modules of idiopathic noncirrhotic portal hypertension (INCPH) and cirrhotic portal hypertension (CPH) and pulmonary hypertension, respectively. Enrichment analysis was performed on the common genes, and differential gene expressions (DEGs) were used for verification. The target genes of INCPH and PAH were obtained by string and cytoscape software, and the miRNAs of target genes were predicted by miRwalk, miRDB, and TargetScan and their biological functions were analyzed; finally, we used PanglaoDB to predict the expression of target genes in cells. In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were “P53 signaling pathway,” “synthesis of neutral lipids”; PAH and INCPH are “terminal,” “Maintenance Regulation of Granules,” and “Toxin Transport.” DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for “P53 signaling pathway,” “TGF-β signaling pathway,” “TNF signaling pathway,” and “fatty acid metabolism,” and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc. In conclusion, the mechanism of pulmonary hypertension induced by portal hypertension may be related to telomere dysfunction and P53 overactivation, and lipid metabolism and intestinal inflammation are also involved in this process.
Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer
Authors: Hua Xu , Li Yongsheng , Pentaparthi Sairahul R. , McGrail Daniel J. , Zou Raymond , Guo Li , Shrawat Aditya , Cirillo Kara M. , Li Qing , Bhat Akshay , Xu Min , Qi Dan , Singh Ashok , McGrath Francis , Andrews Steven , Aung Kyaw Lwin , Das Jishnu , Zhou Yunyun , Lodi Alessia , Mills Gordon B. , Eckhardt S. Gail , Mendillo Marc L. , Tiziani Stefano , Wu Erxi , Huang Jason H. , Sahni Nidhi , Yi S. Stephen
Published: October 2022

Somatic mutations are a major source of cancer development, and many driver mutations have been identified in protein coding regions. However, the function of mutations located in miRNA and their target binding sites throughout the human genome remains largely unknown. Here, we built detailed cancer-specific miRNA regulatory networks across 30 cancer types to systematically analyze the effect of mutations in miRNAs and their target sites in 3′ untranslated region (3′ UTR), coding sequence (CDS), and 5′ UTR regions. A total of 3,518,261 mutations from 9,819 samples were mapped to miRNA–gene interactions (mGI). Mutations in miRNAs showed a mutually exclusive pattern with mutations in their target genes in almost all cancer types. A linear regression method identified 148 candidate driver mutations that can significantly perturb miRNA regulatory networks. Driver mutations in 3′UTRs played their roles by altering RNA binding energy and the expression of target genes. Finally, mutated driver gene targets in 3′ UTRs were significantly downregulated in cancer and functioned as tumor suppressors during cancer progression, suggesting potential miRNA candidates with significant clinical implications. A user-friendly, open-access web portal (mGI-map) was developed to facilitate further use of this data resource. Together, these results will facilitate novel noncoding biomarker identification and therapeutic drug design targeting the miRNA regulatory networks.

Significance:

A detailed miRNA–gene interaction map reveals extensive miRNA-mediated gene regulatory networks with mutation-induced perturbations across multiple cancers, serving as a resource for noncoding biomarker discovery and drug development.
N-myc–Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma
Authors: Kuzuoglu-Ozturk Duygu , Aksoy Ozlem , Schmidt Christin , Lea Robin , Larson Jon D. , Phelps Ryan R.L. , Nasholm Nicole , Holt Megan , Contreras Adrian , Huang Miller , Wong-Michalak Shannon , Shao Hao , Wechsler-Reya Robert , Phillips Joanna J. , Gestwicki Jason E. , Ruggero Davide , Weiss William A.
Published: October 2022

Deregulation of neuroblastoma-derived myc (N-myc) is a leading cause of malignant brain tumors in children. To target N-myc-driven medulloblastoma, most research has focused on identifying genomic alterations or on the analysis of the medulloblastoma transcriptome. Here, we have broadly characterized the translatome of medulloblastoma and shown that N-myc unexpectedly drives selective translation of transcripts that promote protein homeostasis. Cancer cells are constantly exposed to proteotoxic stress associated with alterations in protein production or folding. It remains poorly understood how cancers cope with proteotoxic stress to promote their growth. Here, our data revealed that N-myc regulates the expression of specific components (∼5%) of the protein folding machinery at the translational level through the major cap binding protein, eukaryotic initiation factor eIF4E. Reducing eIF4E levels in mouse models of medulloblastoma blocked tumorigenesis. Importantly, targeting Hsp70, a protein folding chaperone translationally regulated by N-myc, suppressed tumor growth in mouse and human medulloblastoma xenograft models. These findings reveal a previously hidden molecular program that promotes medulloblastoma formation and identify new therapies that may have impact in the clinic.

Significance:

Translatome analysis in medulloblastoma shows that N-myc drives selective translation of transcripts that promote protein homeostasis and that represent new therapeutic vulnerabilities.
Clinical Significance and Properties of IFN-γ+IL-17+ Th17 Cells in Liver Injury Associated with Chronic Hepatitis B Virus Infection
Authors: Xie Hao , Zeng Jingyan , Yan Xiong , Shen Na , Zheng Xiao , Luo Hongchun
Published: October 2022

Introduction: Our previous study demonstrated that intrahepatic Th17 cells exacerbated the progression of chronic hepatitis B virus (HBV) infection. Meanwhile, we found a small group of IFN-γ and IL-17 double-positive Th17 cells (IFN-γ+IL-17+ Th17 cells) in liver tissues. This study aimed to investigate the clinical significance and properties of IFN-γ+IL-17+ Th17 cells in liver injury associated with chronic HBV infection. Methods: The frequencies of CD4+ Th cells, Tregs, and CD4+ T cells expressing specific chemokine receptors in the blood and liver tissues were detected using flow cytometry. The chemotaxis of C C chemokine receptor 5 (CCR5) and C-X-C chemokine receptor 3 (CXCR3) toward IFN-γ+IL-17+ Th17 cells and Tregs was evaluated by transwell chemotactic assay. Analyses of different variables were performed using GraphPad Prism v 5.01 and IBM SPSS Statistics 23.0. HBV-specific IFN-γ+IL-17+ Th17 cells were investigated using a cell stimulation assay with HBV antigens in vitro. Results: The frequencies of IFN-γ+IL-17+ Th17, Th17 cells, and Tregs in the blood were increased from normal controls to chronic hepatitis B (CHB) and acute-on-chronic liver failure (ACLF). The same trend could also be observed in CHB liver tissues compared to those in CHB blood specimens. Furthermore, the frequencies of IFN-γ+IL-17+ Th17 cells were positively associated with Th17 cells, Th17 cell-related cytokines (IL-17 and IL-6), HBV DNA load, and the levels of HBsAg, HBeAg, and ALT. The ratios of IFN-γ+IL-17+ Th17 cells to Tregs extremely decreased in ACLF blood specimens compared with those in CHB blood specimens. Additionally, CCR5 and CXCR3 were conducive to the recruitment of IFN-γ+IL-17+ Th17 cells and Tregs to liver tissue. Conclusions: IFN-γ+IL-17+ Th17 cells have Th17 cell-like properties in the progression of chronic HBV infection. CCR5 and CXCR3 facilitated the recruitment of IFN-γ+IL-17+ Th17 cells and Tregs to the liver. Importantly, the ratio of IFN-γ+IL-17+ Th17 cells to Tregs might be an effective assessment indicator of the severity of liver injury.
Profissionalização da atividade criativa: contexto acadêmico e insegurança do trabalho no México
Authors: Dominguez Juan Bello , Reyes Aguirre Galileo
Published: October 2022

A formação acadêmica dos artistas no México tem variáveis institucionais e contextuais que derivam da precarização criativa e do trabalho. Nos últimos anos, as instituições formadoras do ofício criativo foram orientadas a satisfazer as necessidades de um modelo econômico sustentado no mercado, deixando de lado as qualidades criativas pertencentes à cultura, à arte e à educação. O presente artigo analisa as características acadêmicas e as condições de trabalho daqueles formados em instituições dedicadas a profissionais na arte e na cultura no México. Projetar e atualizar seus programas acadêmicos será o maior desafio das carreiras universitárias em arte e cultura nos próximos anos, para enfrentar a precariedade do campo de trabalho e profissional de seus futuros graduados.
O compromisso artístico e social na arte latino-americana: o ensaio crítico de Marta Traba (1961)
Authors: Cota Junior Eustáquio Ornelas
Published: October 2022

Este artigo tem como objetivo principal analisar como Marta Traba, grande intelectual e crítica de arte latino-americana, tratou no início da década de 1960 a questão do comprometimento do artista com o fazer artístico e o meio social na América Latina. Para isso, analisa-se a sua obra intitulada “La pintura nueva en Latinoamerica”, publicada em 1961, entendida como um dos primeiros trabalhos de maior densidade que a autora estabeleceu reflexões comparativas sobre a pintura na América Latina. O presente trabalho se insere na relação entre arte e história, cultura e poder, e utiliza-se de aportes teóricos e metodológicos da História Social da Arte e da História Intelectual. Supõe-se que com esta primeira obra ensaística mais ampla, Marta Traba realizou um diagnóstico da pintura no pós-II Guerra, criticou vertentes e movimentos existentes na arte e na cultura da região e apontou novos rumos para uma nova geração de artistas, tendo como base exemplos da própria história da arte na América Latina.
Implantação de um protocolo de avaliação e acolhimento baseado na Classificação Internacional de Funcionalidade, Incapacidade e Saúde em um centro especializado de reabilitação
Authors: Zuqui Aline Cáus , Vogler Fernanda Mattos , Carmo Julia Fabres do , Gomes Crystian Moraes Silva
Published: October 2022

O Protocolo de Levantamento de Problemas para a Reabilitação (PLPR) é um instrumento de triagem baseado no modelo da Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF), que sistematiza o acolhimento e possibilita a formação de bancos de dados sobre as demandas funcionais dos usuários de serviços de reabilitação. Objetivo: Relatar e analisar a partir da percepção dos profissionais o processo de implantação do PLPR em uma Unidade de Tratamento Neurológico Adulto de um Centro Especializado de Reabilitação (CER II). Métodos: Trata-se de uma pesquisa descritiva exploratória do tipo qualitativa. Para coleta dos dados foram utilizadas informações documentais e um grupo focal, adotado para compreender a percepção dos profissionais sobre as mudanças no processo de triagem após implementação do PLPR. Utilizou-se como ferramentas de processamento dos dados o software IRAMUTEQ. Resultados: A classificação hierárquica descendente apresentou cinco categorias temáticas de análise: Fluxo e Rede; Acolhimento e Cuidado; PLPR; Triagem; Reabilitação. Conclusão: A falta de uma rede de cuidados à pessoa com deficiência constituída e consolidada foi apontada como uma barreira importante que influencia o processo de reabilitação. A equipe demonstrou compreender a necessidade de reformular os atendimentos, através do modelo conceitual da CIF. Ressaltando que a aplicação do PLPR foi a primeira ação de estruturação deste modelo no serviço, todavia, não houve um consenso se o uso do instrumento promoveu um atendimento mais próximo deste modelo.
Updates on Sturge-Weber Syndrome
Authors: Yeom SangEun , Comi Anne M.
Published: October 2022

Sturge-Weber syndrome (SWS) is a rare, noninherited neurovascular disorder characterized by abnormal vasculature in the brain, skin, and eye. Patients with SWS characteristically have facial capillary malformation, also known as port-wine birthmark, a leptomeningeal vascular malformation seen on contrast-enhanced magnetic resonance imaging images, abnormal blood vessels in the eye, and glaucoma. Patients with SWS have impaired perfusion to the brain and are at high risk of venous stroke and stroke-like episodes, seizures, and both motor and cognitive difficulties. While the activating R183Q
GNAQ
somatic mutation is the most common somatic mutation underlying SWS, recent research also implicates that GNA11 and
GNB2
somatic mutations are related to SWS. Recent retrospective studies suggest the use of low-dose aspirin and vitamin D in treatment for SWS and prospective drug trials have supported the usefulness of cannabidiol and Sirolimus. Presymptomatic treatment with low-dose aspirin and antiepileptic drugs shows promising results in delaying seizure onset in some patients. This review focuses on the latest progress in the field of research for Sturge-Weber syndrome and highlights directions for future research.
Phasing Out Fossil Fuels: Determinants of Production Cuts and Implications for an International Agreement
Authors: Lujala Päivi , Le Billon Philippe , Gaulin Nicolas
Published: October 2022

Fossil fuel producers have a major role to play in curbing greenhouse gas emissions through supply-side initiatives. Yet, no study has systematically assessed the determinants of efforts to constrain fossil fuel production for climate purposes. To contribute to climate change mitigation efforts, this article develops a conceptual framework for factors potentially affecting country-level initiatives to keep fossil fuels in the ground. Using data for 124 countries with fossil fuel reserves for 2006–2019 and multivariate Poisson regression analysis, we identify factors influencing the use of such constraints by national governments. Results show that although dependence on fossil fuel rents reduces the likelihood of constraint measures, the size of fossil fuel reserves or production does not impact it. Richer countries are also more likely to use constraints. Organization of Petroleum Exporting Countries membership constitutes a barrier to having moratoria on fossil fuel extraction. These results can help identify potential members for new fossil fuel supply-side initiatives and coalitions.
An interesting new species of Conocephalus (Orthoptera: Tettigoniidae: Conocephalinae) from Argentina
Authors: BRAUN HOLGER
Published: October 2022

Conocephalus cinnamonifrons sp. nov. is distinguished by a cinnamon brown head and a distinctly upcurved ovipositor from South American congeners with usually green heads and practically straight ovipositors. The short-winged species lives in wetlands near the coast of the Río de la Plata, and has also been recorded from Entre Ríos Province. The calling song of the male shows a distinctive pattern of long syllable trains alternating with short sequences of a few isolated syllables, quite different to the songs of the syntopically occurring C. doryphorus and C. longipes. Some ecological aspects are briefly discussed.
Preparation of Graphene/Chitosan Nanocomposite Scaffold and Its Application in Fracture Treatment
Authors: Cao Le , Lian Ruiming , Wu Yongping , Xiao Shining , Miao Xudong
Published: October 2022

In the early stages, patients with fractures often have massive bleeding, wasting coagulopathy, and injuries to other parts, but in the later stages, they are prone to various complications, leading to high mortality and disability. This study focuses on the preparation of nanomaterial
graphene/chitosan scaffolds and their application in fracture treatment. This article first summarizes the current state of nanomaterial scaffolds, then describes their preparation methods, and finally describes their application in fracture treatment. In patients with fractures, the nanomaterial
graphene/chitosan scaffold can provide a favorable rehabilitation environment at the fracture site. When combined with the auto repair ability of human tissues, it has the potential to accelerate patient recovery. The graphene/chitosan scaffold has a molecular structure similar to natural
bone, making it more suitable for human bone rehabilitation than ordinary fixed scaffolds. The best time between stent implantation and surgery is half a month, which can significantly reduce the risk of postoperative complications. Reoperation for more than 18 days is an independent risk
factor for local cancer recurrence. Therefore, using nanomaterial graphene/chitosan scaffolds in fracture treatment is safe, effective, and feasible. Further future research in this direction is warranted.