bluuebunny/crossref_metadata_2025 huggingface dataset:
THE DEVELOPMENT OF THE SOCIO-PEDAGOGICAL FUNCTION OF SECONDARY SCHOOLS (ON THE EXAMPLE OF THE REPUBLIC OF KARAKALPAKSTAN)
Authors:   Base doctoral student of Nukus State Pedagogical Institute, Republic of Uzbekistan, Karakalpakstan, Nukus city, Uzbekistan, Mendibek Tolegenov
Published: June 2024

A stract. Today the issue of school education is gaining worldwide importance at the same time , it is necessary to further improve the work , reforms and actions carried out in the Republic of Uzbekistan , in particular in the Republic of Karakalpakstan. There are a number of shortcomings that are not linked to the human factor in order for public education schools to fully realize the socio-pedagogical functions of their own in accordance with the requirements of modern development. Therefore, in this article, the issue of the evolution of socio-pedagogical tasks of Higher Secondary Education Schools is considered on the example of the Republic of Karakalpakstan.
THE DIFFICULTY OF USING IRREGULAR SENTENCE BY IRAQI EFL STUDENTS AT UNIVERSITY OF BABYLON
Authors:   Asst. Lect., College of Dentistry, Babylon, Iraq, Alazzawi Wid Wajdi
Published: June 2024

The objective of the study is to investigate the difficulty of using irregular verbs in the students writing an essay at the University of Babylon. The design of this study is descriptive qualitative research. The sample of the study comprised 25 students in their fourth year, and it was selected randomly. The findings of the study showed that 70% of the students were unable to use irregular cases such as verbs and adjectives incorrectly. Also, the findings show that the students use both regular and irregular verb (past) in their students' writing essays. The most dominant verb past written by the students in their students’ writing essay is an irregular verb. Regular verbs are verbs that can change according to tense and change it regularly. Regular verbs are verbs whose changes comply with normal rules, that is with add the letter -d or -ed to the verb first-form/verb-1 (infinitive) so that it becomes a verb form second/verb-2 (past tense). Several things must be considered in the way of forming regular verbs by adding the letter -ed suffix or -d in the basic verb/verb-1 (infinitive). Irregular verbs are verbs that change according to the tense and do not comply with normal compliance. The past tense Irregular verbs are not formed from basic verbs/verb-1 (infinitives) plus letters -d or -ed letters to form verb-2/past tense. Irregular verbs form their past tense differently (through) not always) through a vowel and consonant change. This study recommends students should be well-trained on how to use irregular verbs in the past tense case or changing the form of the regular adjective, and also must be memorized by the learners/students because of the difficulty to distinguish the irregular verbs among the sentences.
POTENSI DAN PROSPEK WISATA HALAL DALAM MENSEJAHTERAKAN MASYARAKAT (STUDI KASUS SITUS SEJARAH MAKAM SULTAN MALIKUSSALEH)
Authors: Zahara Lia , Damanhur Damanhur
Published: June 2024

Penelitian ini bertujuan untuk mengetahui bagaimana potensi dan prospek  wisata halal dalam meningkatkan kesejahteraan masyarakat di Situs Sejarah Makam Sultan Malikussaleh. Jenis penelitian yang digunakan dalam penelitian ini adalah kualitatif deskriptif dengan pendekatan field research dimana peneliti harus terjun langsung ke lapangan guna memperoleh informasi secara langsung dari para informan. Sedangkan teknik pengumpulan data yang digunakan dalam penelitian ini adalah wawancara dan dokumentasi. Hasil yang diperoleh dari penelitian ini menunjukkan bahwa dengan adanya potensi wisata halal ini dapat menjadikan peluang bisnis yang sangat bagus bagi masyarakat sekitar. Serta jumlah pendapatan yang positif yang diperoleh oleh para pelaku usaha sesudah dan sebelum membuka usaha sangat dirasakan oleh masyarakat, sehingga dengan meningkatnya pendapatan maka kesejahteraan masyarakat pun dapat menjadi lebih baik.
THE EFFECTIVENESS OF SOCIALIZATION GROUP ACTIVITY THERAPY (TAKS) ON DEPRESSION IN THE ELDERLY IN GAMPONG KEURAMAT, KUTA ALAM DISTRICT, KOTA BANDA ACEH, IN 2022
Authors: Jannah Miftahul , Laila Nurnarita , Damayanti Ira , Yenni Manovri , Mutia Sri Alna
Published: June 2024

Background: Based on 2021 Ministry of Home Affairs data, there are 418.156 elderly people in Aceh Province. BPS data for Kota Banda Aceh  in2021 shows that there are 55.504 elderly people, and 1,041 elderly people are in Gampong Keuramat, Kuta Alam District, Kota Banda Aceh. Objective: This study aims to determine the effectiveness of Social Group Activity Therapy (TAKS) on depression in the elderly in Gampong Keuramat, Kuta Alam District, Kota Banda Aceh. Method: This research is a Pre-Experimental Design. The population in this study were all elderly people who lived in Gampong Keuramat, Kuta Alam District, Kota Banda Aceh, totaling 1,041 people. The research sample was taken using the Accidental Sampling Technique. Data analysis used the statistical test of the Paired One Sample t-Test and the Chi-square test. Results: The results of the study showed that there was a difference between before and after carrying out Social Group Activity Therapy (TAKS) on depression in the elderly with a value of sig. (2-tailed)=0.000. The results of statistical tests using Chi-square also show that there is a relationship between the history of chronic disease (p-value:0.010) and family income (p-value:0.048) with depression in the elderly in Gampong Keuramat, Kuta Alam District, Kota Banda Aceh. Recommendation: It is recommended that health workers can further increase the role of Posyandu for the elderly, and also cross-sectoral cooperation, especially cooperation in improving the health status of the elderly, and minimizing diseases that occur in the elderly, as well as being more active in inviting the elderly to utilize the health facilities to maintain the health of the elderly.
FACTORS INFLUENCING SELF-MANAGEMENT BEHAVIOR IN HYPERTENSIVE PATIENTS AT LHOKNGA PRIMARY HEALTH CARE
Authors: Ningsih Rima Wirayudha , Wardiati Wardiati , Fahdhienie Farrah , Septiani Riza
Published: June 2024

Background: Hypertension is one of the non-communicable diseases suffered by a large number of people worldwide. Globally, it is estimated that 1.28 billion adults suffer from hypertension. The prevalence of hypertension is increasing, especially among those aged 60 and above.  Self-management is one of the strategies for managing blood pressure in elderly with hypertension. This study aims to explore the relationship between age, gender, education, marital status, knowledge, family support, and self-management behavior among hypertensive patients at Lhoknga Primary Health Care, Aceh Besar District. Method: This study used a descriptive-analytic approach with a cross-sectional design. The study population included 510 hypertensive patients at Lhoknga Primary Health Care, Aceh Besar District. A sample of 85 individuals was selected using purposive sampling. Results: The study findings indicate a relationship between family support (p=0.012) and knowledge (p=0.001) with self-management behavior among hypertensive patients. However, no significant associations were found between the level of education (p=0.560), age (p=1.000), sex (p=0.756), comorbidities (p=0.805), and marital status (p=0.258) with self-management behavior among hypertensive patients. Recommendation: The findings of this study could serve as a basis for healthcare providers at primary healthcare centers to enhance education regarding self-management for hypertensive patients and their families, thereby increasing their awareness and motivation to implement hypertension self-management.
COMPLIANCE OF THE PROSPECTIVE BRIDES AND GROOMS IN LABORATORY EXAMINATIONS AND PREMARITAL COUNSELING IN THE WORKING AREA OF MUTIARA BARAT HEALTH CENTER, PIDIE REGENCY
Authors: Noviyati Ike , Amin Fauzi Ali , Agustina Agustina , Amin Ghazali , Arlianti Nopa
Published: June 2024

Background: Based on Pidie Regent Regulation no. 5  year 2018, states that prospective brides and grooms (Catin) must have their health checked at all nearest health service centers to prevent transmission of infectious diseases (HIV, Hep B, Syphilis),and  treated  if they are at risk of disease, detect early reproductive Catin health problems  with laboratory examinations and premarital counseling. Compliance with prospective brides and grooms in carrying out health checks at the Pidie Regency level is 67%, while at the Mutiara Barat Community Health Center level at the average of 42.5% for HIV and Hep B checks, 40.4% for syphilis checks, and 10.7% for TT screening and 10% did the Plano test. The aim of this research is to see the level of Catin compliance in laboratory examinations and premarital counseling in the Mutiara Barat Health Center Working Area, Pidie Regency in 2019. Method: This research was conducted using a descriptive analytical, crosssectional design method. The population was all 214 prospective brides and grooms registered in the bride and groom report book at the Mutiara Barat Community Health Center. Sampling used a purposive sampling technique. Data analysis used the Chi Square test of the SPSS version 20. Result: The results of the study showed that there were no relationship between Catin's age and premarital examination (p value=0.384), Catin's education (p value=0.755), Catin's job (p value=1.000), availability of laboratory medical equipment (p value=0.330), and area of residence (p-value=0.153). Meanwhile, the gender variable has a significant relationship with laboratory examinations and premarital counseling (p value=0.018). Recommendation: It is hoped that the Puskesmas will collaborate across programs and across sectors to provide innovations that will make Catin more compliant with existing inspections.
FACTORS ASSOCIATED WITH HAND WASHING WITH SOAP (CTPS) BEHAVIOR AMONG STUDENTS AT SMPN 3 KOTA SABANG
Authors: Zuriati Nura , Santi Tahara Dilla , Maidar Maidar
Published: June 2024

Background: Optimal levels of public health can be achieved through various efforts, one of which is disease prevention through hand washing with soap (CTPS). School-age children are prone to various diseases due to low CTPS behavior. The aim of the study was to determine the factors related to CTPS among students at SMPN 3 Kota Sabang. Methods: The research method uses descriptive analytics with a cross- sectional approach. This research was conducted at SMPN 3 Kota Sabang with a sample of 85 students in class VII and VIII. Data collection uses  a structured questionnaire instrument. Data analysis uses univariate analysis to display the frequency distribution of each variable and bivariate analysis uses the chi-square test. Result: The results show that there is a relationship between knowledge (p value = 0.001), attitude (p value = 0.002), and the role of health workers (p value = 0.000) with CTPS behavior, and there is no relationship between the teacher's role (p value = 0.462) with CTPS behavior. Recommendation:  It is hoped that School Health Unit (UKS) officers can provide more extensive education  to students about the benefits of CTPS.
FACTORS RELATED TO COMPLIANCE WITH USING PERSONAL PROTECTIVE EQUIPMENT FOR PESTICIDE SPRAYING FARMERS IN GAMPONG MEUNASAH BLANG PEUDADA BIREUEN
Authors: Putri Hasdiani , Santi Tahara Dilla , Zulkifli Zulkifli
Published: June 2024

Background: Spraying pesticides that do not comply with regulations will result in many impacts, including health impacts for humans, namely poisoning farmers. In Aceh Province, there were 612 cases of pesticide poisoning in 2014 in various regions. This research aims to determine the factors related to compliance with using Personal Protective Equipment (PPE) among pesticide spraying farmers in Gampong Meunasah Blang Peudada Bireuen. Method: This research uses descriptive analytical methods with a crosssectional design. The population in this study were all pesticide spraying farmers in Gampong Meunasah Blang Bireuen. The sample is a total population of 46farmers. Data collection was carried out for 12 days from 1 to 12 January 2019 using questionnaires and interviews. Data analysis used the Chi-Square test with the SPSS computer program. Result: Univariate research shows farmers who do not comply with using PPE (69.6%), poor knowledge (65.2%), negative attitudes (54.3%), secondary education level (43.5%), and medium length of work (50 %). The results of bivariate research show that there is a relationship between knowledge (p=0.03) and attitude (p=0.02) with compliance with using PPE among farmers. However, there was no significant relationship between education (p=0.20) and length of service (p=0.69) with compliance in using PPE among farmers. Recommendation: It is hoped that the Agricultural Extension Center can provide training to farmers on how to use PPE correctly when spraying pesticides and can provide education regarding the magnitude of the effects and dangers of using pesticides incorrectly.
ANALYSIS OF FACTORS ASSOCIATED WITH COMPLETENESS OF BASIC IMMUNIZATION IN BABIES AT THE BANDA RAYA COMMUNITY HEALTH CENTER, KOTA BANDA ACEH IN 2021
Authors: Syawaluddin Syawaluddin , Arbi Anwar , Santi Tahara Dilla
Published: June 2024

Background: Complete basic immunization coverage at the Banda Raya Community Health Center is 67.6%. Low levels of complete basic immunization in babies must be addressed immediately so that children can grow and develop healthily and avoid infectious diseases. This study aims to analyze the completeness of basic immunization for babies at the Banda Raya Community Health Center, Banda Aceh City in 2021. Method:This research is descriptive analytical with a crosssectional design. The sample was 63 patients determined using total population techniques. Data analysis used the Chi-Square test with SPSS version 20. Result: there was a relationship between knowledge (p-value=0.016), parental education (p-valu=0.006), the role of cadres (p-valu=0.040), the role of health workers (p-value0.001), family support (p-value=0.023), and maternal motivation (p-value=0.013) with complete basic immunization for babies at the Banda Raya Community Health Center, Banda Aceh City in 2021. Recommendation: It is hoped that health workers can carry out health promotion, especially community promotion emphasizing the consequences if children are not given basic immunizations, one of which is by socializing the importance of proper immunization according to a predetermined schedule.
FACTORS ASSOCIATED WITH ELECTRIC CIGARETTES USE IN STUDENTS AT SMAN 1 TAKENGON IN 2021
Authors: Yana Nada , Hasnur Hanifah , Sepatini Riza
Published: June 2024

Background: Every year the percentage of teenagers who smoke increases, in 2011, 3.1% of teenagers smoked e-cigarettes and 1.7% of them were still found smoking tobacco cigarettes. In 2012, the percentage of teenagers using e-cigarettes increased quite drastically by 6.5%, with details of 4.1% using e-cigarettes and 2.6% using e-cigarettes (vapes) with tobacco cigarettes, while 2% of them used tobacco cigarettes. The research aims to determine factors that can influence the use of electronic cigarettes (vape) among students at SMAN 1 Takengon. Method: Analytical descriptive research using a cross- sectional design. The sample was taken by accidental sampling with a total of 40 male students. Data collection uses a questionnaire. Analysis uses univariate and bivariate analysis. Results: Bivariate analysis shows that there is a relationship between the affordability of e-cigarettes in accessing purchasing e-cigarettes (p= 0.004) and the use of e-cigarettes, and there is no relationship between knowledge, attitudes, perceptions, pocket money, and peers towards the use of e-cigarettes. Recommendation: It is recommended that the Central Aceh Regency Health Serviceto increase outreach and guidance activities  regarding the dangers of using e-cigarettes, the need for a firm stance from the Central Aceh Regency government in paying attention to age limits for the sale of e-cigarettes.
RELATIONSHIP BETWEEN THE HEALTHY INDONESIA PROGRAM FAMILY APPROACH (PIS-PK): INDICATORS OF NUTRITION, MATERNAL AND CHILD HEALTH WITH STUNTING IN THE FIRST 1000 DAYS OF LIFE IN THE LUT TAWAR COMMUNITY HEALTH CENTER WORKING AREA
Authors: Anggi Tri Yayang , Arlianti Nopa , Amin Fauzi Ali
Published: June 2024

Background: Indonesia is still experiencing problems in child nutrition and growth and development, one of which is stunting. Aceh is one of the provinces with a high percentage of stunting. Central Aceh Regency is a district that is included in the 10th highest cases of stunting in Aceh. The incidence of stunting is very influential since the child is in the first 1000 days of life. The aim of this research is to find out the relationship between the Indonesia Healthy Family Approach Program (PIS-PK): nutritional indicators, maternal and child health with stunting in the first 1000 days of life in the Lut Tawar Community Health Center working area. Method: This research is descriptive-analytic with a cross-sectional approach. The population in this study were all mothers who had children in the first 1000 days of life in the Lut Tawar Community Health Center area, Central Aceh Regency with a total sample of 82 people. The sampling technique uses proportional random sampling. Data collection was carried out using a questionnaire, then statistical tests were carried out using the chi-square test, and data were analyzed using SPSS. Results: The results of the study showed that there was a relationship between the use of contraception/family planning (p value=0.041), delivery in a health facility (p value=0.044), complete basic immunization (p value=0.024), exclusive breastfeeding (p value=0.046) and monitoring child growth (p value=0.043) with the incidence of stunting in children in the first 1000 days of life in the Lut Tawar Community Health Center working area. Recommandation: It is hoped that the Central Aceh District Health Service will add more activities such as counseling on dietary patterns and parenting patterns in households besides PIS-PK in order to reduce the stunting rate in Central Aceh District.
COMMUNICATION RELATIONSHIP OF HEALTH WORKERS TOWARDS THE IMPLEMENTATION OF BASIC IMMUNIZATION IN THE WORKING AREA OF BLANG KUTA HEALTH CENTER, BANDAR DUA DISTRICT, PIDIE JAYA REGENCY
Authors: Munawir Munawir , Ichwansyah Fahmi , Azwar Eddy
Published: June 2024

Background: Basic immunization coverage in Pidie Jaya Regency from January to December was 29.6% for measles immunization. One of the health centers with the lowest basic immunization is Blang Kuta at 12.9%. This research aims  to determine the relationship between health worker communication and the implementation of basic immunization in the work area of the Blang Kuta Health Center. Methods: This research is descriptive- analytic with a cross-sectional design. The population in this study was 145 mothers who had babies aged 0-12 years in the Blang Kuta Community Health Center working area. The sample, consisted of 60 respondents who were determined using the Proportional Random Sampling technique. Data analysis used the Chi-Square test with SPSS. Results: Based on univariate analysis shows that the implementation of basic immunization in the Kuta Blang Health Center working area is still low (61.7%), there is a lack of information sources (71.7%), there is a lack of media (76.7%), there is a lack of communication messages (73.3%), lack of recipients of information (58.3%). Based on bivariate analysis, there is a relationship between information sources (p value=0.012), communication messages (p value=0.043), and recipients of information (p value=0.015) on the implementation of basic immunization in the Blang Kuta Community Health Center Working Area in 2019. Recommendation: Health workers should improve their effective communication skills, so they can  provide good and clear information about immunization procedures to the public, especially mothers who have babies and toddlers.
Analisis Kebutuhan dan Ketersediaan Air Bersih Kecamatan Darul Imarah Kabupaten Aceh Besar
Authors: Listia Vina , Yulia Yulia , Muazzin Mirza
Published: June 2024

Fulfilling sterile water requirements is highly dependent on sterile water sources availability. The problem faced every dry season in Darul Imarah was that around 85% areas did not support with sterile water. The people merely have it from drilled wells, so that it is necessary to analyze the need for sterile water until 2033. The aims of this research were to analyze the total need for sterile water in Darul Imarah district area, to investigate whether the reservoir capacity was sufficient for water needs in 2033 and to figure out the existing of water availability met the needs and sufficiency in Darul Imarah district area until 2033. It is hoped that based on the result of this study could provide information and knowledge to Darul Imarah community about the need and availability of sterile water especially for provision and water consumption. The analysis of the projected population and Local Water Company Mountala customers using the arithmetic method resulted sterile water need and availability and reservoir volume. In 2033, the population in this district will achieve 60,965 people with 14,109 customers. The need for sterile water in 2033 based on the increased number of customers and residents was 143.10 liters/second. Broncap Gle Taron's water needs considered still be able to meet the clean water needs for the current service area until 2033. This was proven by the total clean water need in 2023 would be 150 liters/second. The reservoir required in 2033 would be 2472.83 m3. The reservoir storage volume at Local Water Company Mountala was 1 unit with storage of 500 m3. The shortage of reservoir capacity was 1972.83 m3 or it requires 4 additional reservoir units to meet water availability in 2033. The need for sterile water increasing every year to minimize water shortages, so it is necessary to consume water effectively.
Analisis Tipe Rumah Tinggal Terhadap Ancaman Bahaya Tsunami Di Kota Banda Aceh
Authors: Soviana Widya , Husaini Husaini
Published: June 2024

People who lived on the Banda Aceh City shoreline lost their houses in the 2004 tsunami tragedy. The likelihood of a tsunami tragedy in the future might rise if homes are rebuilt in the original location. The goal of this study was to determine the most common building types and the degree of susceptibility of residential structures to the tsunami catastrophe in the districts of Kuta Alam and Syiah Kuala. Through a sample approach, a questionnaire was given out to the community in the districts of Kuta Alam and Syiah Kuala, with a total of 105 responses. To gather representative home building types at the research site, a survey was undertaken. data processing with the use of the validity and reliability tests in SPSS. The questionnaire was deemed legitimate as a result of the validity test, which produced average R count values of 0.1918 and higher than the value of r table. The reliability test findings were dependable since they had a Cronbach Alpha score of 0.671, which is higher than 0.6. The predominant home types in the Kuta Alam and Syiah Kuala subdistricts are type B (good) and type C (poor) dwellings. Low, medium, and high levels of vulnerability were used to determine how vulnerable residential buildings were to the tsunami tragedy in the Kuta Alam District. The Syiah Kuala District, meanwhile, had high and moderate degrees of vulnerability. According to the physical state of the environment in the districts of Kuta Alam and Syiah Kuala, 19% of the coastal regions are still in their original state, and 81% of the territory is made up of grib stones and mangroves. In the Kuta Alam sub-district, there are 11 villages overall, with the percentage of vulnerable structures falling into one of three categories: low (45.45%), medium (45.45%), or high (9.09%). In the Syiah Kuala District, however, the degree of vulnerability of residential structures was determined from a total of 10 villages, and it was divided into two classes: medium, with a percentage of 40%, and high, with a percentage of 60%. As a result, it's important to upgrade the design of communal housing in coastal locations, such as by constructing homes with two or more levels.
PENGARUH KUALITAS PELAYANAN TERHADAP KEPATUHAN PEMBAYARAN PAJAK RESTORAN DI KOTA GORONTALO
Authors: Putri Sri Susanda Amalia , Katili Andi Yusuf , Syarta Ahmad Akmal Hi , Hasan Sofyaningsi J. , Pariono Agus
Published: June 2024

The purpose of this study is to provide an overview of restaurant tax payment compliance in Gorontalo City. The research method used is descriptive with a quantitative approach. A purposive sampling strategy was used to select 92 respondents as a sample for this study. The type of data used is primary data, which is the result of sending questionnaires to Gorontalo City restaurant tax payers. In this study, linear regression analysis was used with a partial test (t-test) to analyze the data. These findings indicate that compliance with restaurant tax payments is positively and significantly influenced by the level of service. The coefficient of determination of the study is 24.2%, which means that the service quality variable can take into account the restaurant tax payment compliance variable.
Pengaruh pay transparency terhadap job satisfaction, turnover intention, dan organizational commitment serta perceived organizational support sebagai variabel mediasi
Authors: Wati Diyana , Putra Andreas Wahyu Gunawan , Tanuwijaya Justine
Published: June 2024

This study aims to investigate the effect between pay transparency and Perceived Organizational Support and its impact on job satisfaction, turnover intention, and organizational commitment. This study was conducted at PT XYZ by involving employee respondents in various divisions. The research method used was a survey using a questionnaire as a data collection instrument. The research sample consisted of 136 respondents using a saturated sample. Data analysis was performed using descriptive statistical techniques and SEM. The results of the study show that there is a significant relationship between pay transparency and Perceived Organizational Support. This finding indicates that the level of payroll transparency in an organization influences the support felt by employees for the organization. Furthermore, Perceived Organizational Support was also found to have a positive and significant relationship with job satisfaction, turnover intention, and organizational commitment. In addition, this study also reveals that pay transparency has a significant effect on job satisfaction through Perceived Organizational Support. That is, payroll transparency can affect the level of job satisfaction through the level of organizational support felt by employees.
THE SIGNIFICANCE OF GHRELIN AND LEPTIN GENE POLYMORPHISMS IN THE RESULTS OF BARIATRIC SURGERY
Authors: Prodan A. M. , Kamyshnyi O. M. , Dzubanovsky I. Ya.
Published: June 2024

Abstract. Aim. Metabolic syndrome is a combination of hereditary metabolic disorders that ultimately lead to the development of cardiovascular complications and diabetes, often associated with mutations in specific genes and explained by aberrant expressions. Some single nucleotide polymorphisms (SNPs) play an important role in the obese human population.
Methods and materials: Genotyping of GHRL, LEP and LEPR gene polymorphisms (rs696217, rs7799039, rs1137100, rs1137101, and rs1805094) in 48 patients of the control group and in 53 patients with metabolic syndrome have been performed. Bariatric surgery inclu-ded — laparoscopic gastro plication — 22 patients, laparoscopic sleeve-gastrectomy — 15 patients, embolization of the left gastric artery — 7 patients.
Conclusions. The presence of the LEPR gene polymorphism (rs1137101) in the Ukrainian population indicates an increased risk of developing metabolic syndrome regardless of the variant - homozygous or heterozygous genotype (AA, AG, GG). Carriers of the GHRL T allele (rs696217) were statistically significantly higher in patients with metabolic syndrome in the Ukrainian population. A significantly greater influence of the T allele of GHRL (rs696217) on the postoperative reduction of excess body weight and ghrelin level in patients after ghrelin-reducing bariatric surgery (sliver resection and embolization) was also established.
DEPENDENCE OF COMPLICATIONS AFTER ERCP ON THE NATURE OF EXTRAHEPATIC BILE TRACT OBSTRUCTION
Authors: Mamontov I. M. , Tamm T. I. , Kramarenko K. O. , Nepomniashchyi V. V. , Ryabushchenko D. D. , Shakalova O. A. , Ustinov A. T. , Tkemaladze D. Yu.
Published: June 2024

Summary. Background. Endoscopic retrograde cholangiopancreatography (ERCP) and associated interventions play a crucial role in the diagnosis and treatment of choledocholithiasis, correction of malignant biliary obstruction, and pathology of the major duodenal papilla. The main complications of ERCP are acute pancreatitis, bleeding, perforation, cholangitis and acute cholecystitis.
Aim. To analyze the presence of complications following ERCP and endoscopic interventions, depending on the nature of the obstruction of the extrahepatic biliary tract – malignant or non-malignant.
Materials and Methods. We analyzed 604 cases of extrahepatic bile duct obstruction (EHBDO) in which endoscopic techniques were utilized for treatment.
Results. Among 498 patients with non-malignant obstruction, acute pancreatitis occurred in 35 (7%), bleeding in 14 (2.8%), perforation in 1 (0.2%), cholangitis in 1 (0.2%), and acute cholecystitis in 4 (0.8%). Among 106 patients with tumor obstruction, the respective figures were 2 (1.9%), 3 (2.8%), 1 (1%), and no cases of acute cholecystitis.
Conclusions. The most common complication following ERCP and endoscopic interventions on the biliary tract is acute pancreatitis (6.1%). It occurs significantly more frequently in cases of non-malignant EHBDO (p=0.046). Bleeding, perforation, and acute cholecystitis were observed in 2.8%, 0.3%, and 0.7% of patients, respectively. No statistical differences were found between malignant and non-malignant obstructions in terms of these complications (p>0.05). Cholangitis, occurring in 0.7% of cases, was significantly more common in patients with tumor-related EHBDO (p=0.003) and was associated with the failure of endoscopic bliary decompression.
CLINICAL CHARACTERISTICS OF ADHESION DISEASE AFTER SURGICAL INTERVENTIONS ON THE PERITONEAL CAVITY ORGANS
Authors: Savchuk A. Yu. , Polyovyy V. P.
Published: June 2024

Summary. The aim of the study: to evaluate the possibilities of using various parameters as prognostic criteria for the development of adhesion disease (AD) after surgical interventions on the organs of the peritoneal cavity.
Materials and methods. The results of treatment and analysis of clinical data of 102 patients with AD are presented. Patient management, diagnosis and treatment of complications were carried out in accordance with the recommendations of the Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (2018). Clinical and epidemiological parameters, surgical anamnesis were taken into account, statistical analysis was carried out using StudentDV4 and Microsoft Excel computer programs.
The results. It was found that patients with AD had a history of previous surgery, trauma, and purulent-inflammatory pathology. Planned and urgent operations occurred in almost the same number of patients, but urgent interventions prevailed by 7.86%. Most often, it is an intervention on the intestines, half as often – in the gastro-duodeno-pancreatobiliary area, due to abdominal trauma and gynecological pathology. The risk of adhesion formation, according to the data obtained, was reduced by an order of magnitude when using laparoscopic access compared to open.
Conclusions. Adhesion disease is a serious and complex complication of surgical interventions on the organs of the peritoneal cavity, while open access creates the greatest risk for adhesion formation, and the use of a minimally invasive approach reduces the likelihood of AD. In this study, no relationship was established between gender, age, or the specifics of surgical interventions and the occurrence of peritoneal cavity adhesions.
INTRAPULMONARY HEMORRHAGES IN CLOSED COMBAT TRAUMA OF THE CHEST
Authors: Boyko V. V. , Khashchyna V. A. , Minukhin D. V. , Serenko A. A. , Tkachenko V. V. , Krytsak V. V. , Korzh P. I. , Abdullaev P. R.
Published: June 2024

Abstract. The share of mechanical chest injuries in the structure of combat trauma is 35-45 % of the total number of chest injuries. More than 70 % of cases of closed injuries of the chest are mainly the result of the indirect effect of the blast wave. At the same time, bruises and ruptures occur more often, cavities in the lungs are formed less often. A high velocity of the damaging factor leads to alveolar trauma or subpleural hematomas, while a low velocity leads to central lung ruptures or large bronchus ruptures. The main methods of diagnosing lung damage due to closed combat trauma of the chest are radiological, which include standard x-ray examination, spiral computer tomography, and ultrasound diagnostics. The majority of domestic and foreign authors believe that among all methods of diagnosing lung damage, priority belongs only to CT as a highly informative and sensitive research method. The main task in the treatment of lung abscess is the active prevention of atelectasis, edema, pneumonia, abscess formation and the development of ARDS. The most difficult point in the treatment of patients with closed lung injuries is determining the indications for thoracotomy.
THE REASONS FOR THE DEVELOPMENT OF COMPLICATIONS DURING COLONIC ANASTOMOSES
Authors: Boyko V. V. , Okley D. V. , Nemenko S. O.
Published: June 2024

Abstract. The article analyzes the literature data on the causes of complications during colonic anastomoses.
The problem of the development of postoperative complications associated with anastomosis is quite relevant in colorectal surgery. The frequency of such complications reaches 27.5 %. These include strictures of the anastomosis, bleeding, as well as failure of the anastomotic sutures. Anastomosis failure ranges from 3 to 21 %. Risk factors for the development of anastomosis failure can be classified into preoperative, intraoperative, and postoperative. And also factors related to the surgeon, the patient and the disease. Fundamental study of the influence of these factors on anastomotic healing is the key to minimizing the frequency of complications and improving the outcome of patients with colon pathology.
THE CURRENT STATE OF DIAGNOSIS AND TREATMENT OF PATIENTS WITH PERITONEAL ADHESIVE DISEASE
Authors: Boyko V. V. , Yevtushenko D. O. , Taraban I. A. , Minukhin D. V. , Lavrynenko A. S. , Vyshniakov K. A.
Published: June 2024

Summary. The article deals with the issue of diagnosis and choice of treatment for patients with peritoneal adhesions and its complications. The adhesion process is a natural consequence. the absolute majority of surgical interventions on the organs of the abdominal cavity, occurring with a probability of 95%. Up to 30% of patients who have undergone surgery for the dissection of adhesions require repeated interventions in connection with the recurrence of the adhesion process, and the mortality from the consequences of adhesion disease in the form of acute small intestinal obstruction reaches 30%. Pаtients with peritoneal adhesive diseаse require a detailed exаmination in order to determine the treаtment algorithm for this category of patients. Despite various attempts by surgeons to reduce the formation of adhesions, none of the currently existing approaches allows to obtain a final result that satisfies the goals. To diagnоse the cаuse of obscure abdominal pain in recent years have increasingly used the lаparoscopic approach. Laparoscopic viscerolysis is widely used to treat pаtients with аabdominal аdhesions diseаse.
FEATURES OF HEMODYNAMIC INDICATORS IN PATIENTS WITH INCREASED BODY MASS INDEX DURING LAPAROSCOPIC CHOLECYSTECTOMY USING DIFFERENT ANESTHESIA METHODS
Authors: Долгополова А. В. , Volkova Yu. V.
Published: June 2024

Summary. Objective. To evaluate the safe energy efficiency of blood circulation in different variants of anaesthetic support for laparoscopic cholecystectomy based on the study of basic haemodynamic parameters in patients in the perioperative period.
Material and Methods. We examined 84 patients with grade II obesity with acute cholecystitis. The effectiveness of the proposed methods of anaesthetic support was evaluated in a cohort prospective randomised simple open clinical trial. The control points were premedication, induction, intubation, CO2 insufflation, CO2 desufflation, extubation, 3 hours after the end of the operation. The average age of the patients (women) was (58.4±6.1) years, and the level of surgical risk according to ASA was grade II. Patients were divided into 2 groups: Group I, 42 patients, who received total intravenous anaesthesia based on propofol through a perfuser and fentanyl; Group II, 42 patients, inhalation anaesthesia based on sevoflurane using a low-flow method and fentanyl. The effectiveness of anaesthetic protection in all groups was assessed based on the analysis of clinical symptoms and changes in the main hemodynamic parameters: heart rate, mean arterial pressure, arterial blood saturation, perfusion index using the Mindray ePM15 monitor. The target level of anaesthetic depth was 60 on the BIS monitor.
Results and discussion. The study showed that the groups of patients were randomised according to anthropometric and gender parameters, duration of surgery and anaesthesia, and baseline somatic status: the average body weight was (98.6±8.2) kg, the average height was (168.2±9.6) cm, the average body mass index was 37.1±1.8, the average duration of anaesthesia was 49.32.6 min, the average Charlson comorbidity index was 1.6±0.2 (the prognosis of survival after surgery was high, >90%). In patients of groups I and II, there were significantly significant differences between the perfusion index at the time of intubation, CO2 insufflation, CO2 desufflation and 3 hours after surgery, which were (3.6±0.2) % and (4.2±0.2) %, (3.9+0.1) % and (4.4+0.2) %, (3.9+0.2) % and (4.6+0.1) %, and (4.1±02) % and 4.7±0.2%, respectively.
Conclusions. During laparoscopic surgery, it is important to maintain the energy efficiency of blood circulation at the reference functional level, since microcirculatory disorders and its slow recovery contribute to the occurrence of complications in the postoperative period.In patients with an increased body mass index during laparoscopic cholecystectomy, the choice of anaesthetic support is in favour of inhalation anaesthesia based on sevoflurane using the low-flow method and fentanyl.
PERFORMING POSTERIOR SURGICAL ACCESS DURING TOTAL HIP REPLACEMENT IN PATIENTS WITH OSTEOARTHRITIS AND CONCOMITANT CARDIAC PATHOLOGY
Authors: Buryanov О. А. , Vako D. І.
Published: June 2024

The aim of our study was to study the severity of operative stress and the assessment of pain status during total hip replacement (THR) using a posterior approach in patients with osteoarthritis and concomitant cardiac pathology.
Materials and methods. 35 patients with osteoarthritis of the hip joint and accompanying cardiac pathology, who came to the “Institute of the Heart of the Ministry of Health of Ukraine” for THR, were examined. In all patients, the main biochemical markers of the body’s stress hormonal response were determined, in particular: levels of insulin, cortisol, glucose in the blood serum, which were measured before surgery, as well as, immediately after surgery, 24 hours later, a week after it, at each of these stages the HOMA (Homeostasis model assessment) index was calculated.
Results. THR was accompanied by certain dynamics of stress indicators. The intensity of the pain syndrome, measured by the VAS, reached its peak one day after the operation, on the 7th day it significantly decreased, but the pain did not disappear. The index of insulin resistance, the HOMA index, which in a certain way reflects the intensity of stress reactions, increased significantly after surgery, did not change significantly, and on the 7th day almost returned to the initial level (p = 0.085). The cortisol level changed reliably throughout the study. After the operation, it increased, then decreased. On the 7th day after surgery, cortisolemia became significantly lower than the initial level.
Conclusions. Performing posterior surgical access during THR in patients with osteoarthritis and concomitant cardiac pathology causes changes in the intensity of stressor reactions.
DYNAMICS OF THE HISTOLOGICAL STRUCTURE OF UVEAL MELANOMA IN THE KHARKIV REGION
Authors: Panchenko M. V. , Honchar O. M. , Boieva Yu. Yu. , Ivzhenko L. V. , Kitchenko I. V.
Published: June 2024

Resume. Uveal melanoma is one of the most common primary intraocular malignancy in adult patients (Mouriaux F., 2014).
The objective of the investigation was to study the dynamics of cell type of uveal melanoma in Kharkiv region in the last 30 years.
Materials and Methods. The results of histological investigations of uveal melanoma were analyzed in 82 patients (33 male and 49 female) aged from 28 to 86 years having been treated in ophthalmology department of Kharkiv regional clinical hospital during the last 30 years. The cell type tumor was determined according to the modified Callender’s classification.
Results. The average age of the patients was 61,2 years. The spindle cell melanoma was diagnosed in 29 patients (35,4 %), epithelioid cell type was found in 24 (29,3 %) and mixed cell type – in 27 (32,9 %). Tumor necrosis was found in two patients. The percentage of patients with epithelioid cell melanoma during the first and second decades was about the same (61,9 % and 59,5 % respectively), and in the last 10 years some increase was noticed up to 68,4 %.
Conclusions. An increase of epithelioid cells melanoma incidence from 59,6 % to 65 % was observed in Kharkiv region during the last 15 years, and up to 68,4 % - during the last 10 years.The average age of patients with uveal melanoma in Kharkiv region has increased from 57,8 to 65,6 years throughout the span of the last 15 years.
PATHOGENETIC JUSTIFICATION OF IMMUNOCORRECTION IN PATIENTS WITH PYELONEPHRITIS DEPENDING ON THE FORM OF THE DISEASE
Authors: Shapoval S. D. , Vasylevska L. A.
Published: June 2024

Abstract. Goal. To find out the state of the cellular link of the immune system in patients with pyelonephritis, followed by the justification of the appointment of immunocorrectors.
Materials and methods. Retrospectively and prospectively analyzed 236 disease histories of patients who received inpatient treatment in the center of purulent-septic surgery of KNP “City Hospital №3” in Zaporizhia for the period 2016-2022. The main group consisted of 114 patients, the comparison group - 122 patients.
The results. Practically all forms of dysentery, both primary and recurrent, occur against the background of secondary immunodeficiency with varying degrees of immune disorders. Patients with erysipelas of all forms, which occur against the background of secondary immunodeficiency in the first degree of immune disorders (which is probably a transitory state), do not need correction with immunomodulators, while patients with II and III degrees, who are immunologically compromised, require mandatory the appointment of immunomodulators.
Conclusions. Studies of the cellular link of the immune system in patients with dysentery contribute to the development of approaches to the appointment of pathogenetically justified immunocorrection, which allows achieving a stable remission or, at least, reducing the risk of chronicity and aggravation of the disease.
EARLY SURGICAL TREATMENT OF DEEP CIRCULAR BURNS WITH COMPARTMENT OCCURRENCE — SYNDROME BASED ON OBJECTIVES OF INTRA-TISSUE PRESSURE
Authors: Kravtsov O. V.
Published: June 2024

Abstract. Introduction. The frequency of burns increases especially during war, when not only the military, but also the civilian population is involved in hostilities. Compartment syndrome is a serious complication of deep circular burns and causes an increase in subfascial pressure and local tissue ischemia with the development of intercellular interstitial edema, which increases the disruption of tissue blood supply, which, in turn, increases the hypoxic state of tissues. Timely and effective diagnosis of compartment syndrome and early surgical treatment help to reduce intratissue pressure and reduce the scale of necrobiotic processes in damaged tissues.
The purpose of the work improvement in the clinic of optimal variants of surgical tactics for the elimination of compartment syndrome occurrence in circular deep burns based on the study of the dynamics of intratissue pressure indicators.
Materials and methods. The research used the results of treatment of 12 victims with deep circular burns who were hospitalized in the Kharkiv Burn Center in the period from 2022 to 2023. All patients were divided into the main and comparison groups. Patients of both groups were measured intratissue pressure in dynamics using the system Kompartmentdruck Monitor System фірми MIPM Mammendorfer Institut für Physik und Medizin Gmbh (Germany).
Research results. The difference between the performed necrofasciotomy and primary necroctomy in the main group was (8±1) mm Hg. due to more radical decompression of thermally damaged tissues. The advantage of the proposed surgical treatment of victims with thermal injury was the possibility of earlier performance of free autodermoplasty with mesh grafts in patients of the main group already by (7.3 ± 0.5) days compared to (11.6 ± 0.6) days in the comparison group. The terms of skin restoration in patients of the main group were (22.8 ± 1.2) days, and in the comparison group (28.6 ± 0.8) days, which made it possible to reduce the time of inpatient treatment from (34.5 ± 0.9) days in the comparison group to (27.5 ± 0.7) days in the main group.
Conclusions. Thus, improving the early surgical treatment of victims with circular deep burns by performing necrofasciotomy and primary necroctomy within 18.6 hours of the patient’s admission to the burn unit allowed to objectively confirm the importance of reducing intratissue pressure as a factor that forms the secondary deepening of the burn wound. Prevention of the deepening of the burn wound made it possible to create optimal conditions for the formation of granulation tissue and autodermoplasty.
FEATURES OF SURGICAL TREATMENT OF FAMILY TUBERCULOSIS
Authors: Duzhyi І. D. , Shevchenko Yu. Yu. , Hresko I. Ya. , Kirichenko Н. M.
Published: June 2024

Summary. A peculiarity of the tuberculosis epidemic situation is that the abacillation of patients with multidrug-resistant tuberculosis in Western Europe reaches 60–65 %, and in Ukraine – no more than 40–45 %, after which these patients remain on outpatient palliative treatment, replenishing the «mobile» fund of sources tuberculosis.
The purpose of the paper. To compare the effectiveness of surgical treatment of sources of tuberculosis and contacts.
Materials and methods. The peculiarities and effectiveness of the treatment of patients with familial tuberculosis and the place of surgical methods in this case were studied. General, microbiological and radiation research methods were applied. Resection, collapsosurgical, simultaneous operations.
Research results. Indications for surgical treatment of tuberculosis sources were established in 24,3 % of patients, but 10,1 % underwent surgery. Among the contacts, indications for surgical intervention were established in 22,0 %, and 7,5 % of patients who underwent surgery.
Most of these patients had multidrug-resistant tuberculosis. Considering this fact, operative interventions were performed at the background of pneumoperitoneum and 2–3 months after the operation. A significant percentage of operations were simultaneous. The second surgical intervention was operations to reduce the volume of the hemithorax, which prevented overstretching of the lung and possible reactivation of tuberculosis.
Conclusion. Better results in operated contactors are a consequence of proper organization of the medical and diagnostic process.