bluuebunny/crossref_metadata_2025 huggingface dataset:
Sazonalidade do regime de chuva nas mesorregiões do estado de Pernambuco, Brasil
Authors: Barbosa Wenderson Gomes , Carvalho Jaine de Moura , Silva Denise Honorato Lopes da , Silva Júnior Arundo Nunes da , Araújo Lidiane da Silva , Silva Antonio Samuel Alves da , Ferreira Tiago Alessandro Espínola , Cristino Claudio Tadeu , Stosic Tatijana
Published: November 2023

Este trabalho tem como objetivo classificar os regimes de chuva dos municípios pernambucanos de Petrolina (Sertão do São Francisco), Araripina (Sertão pernambucano), Garanhuns (Agreste), Rio Formoso (Zona da Mata) e Abreu e Lima (Metropolitana do Recife) com base na extração da sazonalidade de dados mensais de precipitação. O estudo é realizado pelo método da sazonalidade, com que são calculados os índices de sazonalidade (individual e geral) e o índice de replicabilidade (RI), e na análise de tendência pelo método de Mann-Kendall e Sen’s slope. Os dados analisados foram disponibilizados pela Agência Pernambucana de Águas e Clima – APAC, e correspondem aos registros de precipitação mensal captados entre 1995 e 2020 em estações meteorológicas situadas em cada município. Resultados dos testes Mann-Kendall e Sen’s slope indicaram que não houve tendência estatisticamente significativa na sazonalidade anual dos regimes de chuva para nenhuma das estações pluviométricas investigadas. De acordo com o índice de sazonalidade geral, os regimes médios de chuva nos municípios de Garanhuns (Agreste), Rio Formoso (Zona da Mata) e Abreu e Lima (Metropolitana do Recife) para o período analisado foram classificados como bastante sazonal com curta estação seca, enquanto que, nos municípios de Araripina (Sertão pernambucano) e Petrolina (Sertão do São Francisco), foram classificados como marcadamente sazonal com longa estação seca. Além disso, todos os municípios apresentaram regimes médios de chuva com alta replicabilidade, sendo a mais baixa em Petrolina (com RI = 0,69) e a mais alta em Rio Formoso (com RI = 0,80).
Relação de hábitos orais deletérios e bruxismo na infância - Revisão integrativa da literatura
Authors: Borges Antonia Maysa Costa , Silva Renata Maria Ferreira da , Araújo Tainá de Castelo Branco
Published: November 2023

O bruxismo é uma condição caracterizada pela atividade repetitiva de ranger ou apertar dos dentes, geralmente involuntária, que ocorre durante o sono (bruxismo do sono) ou em estado de vigília (bruxismo de vigília), e que se associada a outros distúrbios orais deletérios podem desencadear danos ao sistema estomatognático. O objetivo do trabalho é identificar os principais achados na literatura sobre a relação de hábitos orais deletérios e bruxismo na infância. Este trabalho é uma revisão integrativa da literatura, na qual foram selecionados 16 artigos, publicados na língua inglesa e portuguesa, entre 2013 e 2023, nas bases de dados Scielo, Lilacs e Pubmed. A manifestação do bruxismo em crianças, pode ser desencadeada por estresse, ansiedade, disturbios do sono, alterações respiratórias e alterações na mordida. Somado a isso, hábitos orais deletérios, como sucção não nutritiva (uso de chupetas) e sucção digital, podem ser prejudiciais à saúde bucal. Foi constatado que não existe uma linearidade metodológica entre os estudos realizados sobre a relação dos hábitos orais deletérios e o bruxismo, o que resulta nas disparidades entre idades, gênero e aspectos biopsicossoais entre as amostras. Dessa forma, é imprescindível que protocolos sejam criados de modo a uniformizar as avaliações, para que se possa identificar o dinamismo desses distúrbios nas diferentes amostras, e assim, se torne possível indicar o tratamento adequado para os acometidos.
Entrepreneurship: Pembuatan yoghurt berbahan dasar susu fullcream guna diversifikasi olahan pangan menyehatkan
Authors: Agustina Rini , Heriyawati Dwi Fita , Marisa Fitri , Suprianto Dodit
Published: November 2023

Yoghurt sangat bermanfaat karena kandungan probiotiknya yang bermanfaat, yoghurt sering dikaitkan dengan probiotik yang mempunyai efek positif pada kesehatan sistem imun, konsumsi yoghurt pada anak juga dapat dikaitkan dengan pola hidup sehat dan pola makan, selain kaya nutrisi, yogurt merupakan salah satu primadona pengganti makanan ringan dan dapat membantu anak-anak dan remaja mengembangkan perilaku sehat yang meningkatkan keseimbangan energi. Tujuan dari kegiatan ini adalah memberikan pelatihan pembuatan yoghurt dengan bahan sederhana dan dengan harga terjangkau bagi warga desa. Kegiatan ini menggunakan metode PAR (Participatory Action Research) dimana audience diajak langsung terlibat dalam pembuatan yoghurt. Kegiatan pelatihan dan pendampingan pembuatan yoghurt berbahan dasar susu fullcream dilakukan melalui praktek secara langsung, dengan mengikuti langkah-langkah fermentasi hingga proses pemberian pasta dan penyimpanan. Warga terlihat antusias dan bersemangat mengikuti kegiatan pelatihan dari awal hingga akhir kegiatan. Kegiatan ini memberikan manfaat dalam meningkatkan derajat kesehatan warga desa melalui olahan pangan berdasarkan bahan yang mudah didapatkan di sekitar desa. Melalui kegiatan pendampingan pembuatan yoghurt ini, warga dapat memulai bisnis rumahan berupa yoghurt yang tentunya lebih sehat karena diproses dan diolah sendiri tanpa bahan pengawet. Kelanjutan dari kegiatan ini diharapkan BUMDES mampu mendampingi warga untuk mengelola olahan pangan yang dapat menghasilkan income bagi warga, melalui pembuatan yoghurt.
Pengembangan media pembelajaran seni digital dan kerajinan tangan berbasis website bagi anak-anak dan kaum disabilitas
Authors: Biki Syamsul , Pilomonu Mentari Rizki Sawitri , Saleh Ellen , Juana Andi
Published: November 2023

Fakta menunjukkan bahwa perempuan, anak-anak, dan kaum disabilitas masih kurang dalam memperoleh pendidikan yang layak dalam mengembangkan pengetahuan dan keterampilan seni mereka. Untuk merespon hal tersebut, tim membuat alternatif pembelajaran mengenai seni yang berfokus pada seni digital, kerajinan tangan, dan musik yang dikemas dalam sebuah platform website yang diberi nama “Nyeniman” (singkatan dari nyeni dan seniman). Website ini menawarkan konten edukasi yang menarik seperti video tutorial, DIY, dan blogs seputar seni yang dapat diakses secara gratis. Metode yang digunakan adalah metode partisipatif dimana melibatkan mahasiswa Manajemen kelas J mata kuliah Manajemen Bisnis Kawasan dan para masyarakat, mahasiswa. Pelaksanaan kegiatan ini mempunyai beberapa tahapan yang harus dilakukan yaitu 1) Tahap persiapan, 2) Tahap pelaksanaan kegiatan, 3) Tahap Analisis usaha. Hasil dari kegiatan ini menunjukkan bahwa masyarakat, dosen, dan mahasiswa sangat antusias mengikuti kegiatan pengenalan website, di halaman rektorat Universitas Negeri Gorontalo. Website “Nyeniman” yang dibuat agar para anak-anak, perempuan, dan kaum disabilitas dapat dengan mudah mengakses materi pembelajaran dan pelatihan mengenai seni digital, kerajinan tangan, dan musik tanpa harus terbatas oleh faktor geografis atau fisik. Kedepan platform ini perlu ada perbaikan secara sistemik dan fitur serta tampilan agar bisa menjangkau pasar internet yang lebih luas dan ramah akan pengguna yang berkebutuhan khusus.
Penerapan immersive experiential learning model dalam pembelajaran kewirausahaan melalui game simulasi MonsoonSIM bagi siswa/i SMK
Authors: Santika Reva Ragam , Kusumawardhany Nidya , Sunarwibowo Rizky Pratomo
Published: November 2023

Pembelajaran kewirausahaan adalah bagian dari kurikulum pendidikan SMK untuk membekali siswa dengan keterampilan yang relevan dengan dunia bisnis, namun pendekatan pembelajaran konvensional kurang memadai untuk mengembangkan pemahaman dan keterampilan praktis kewirausahaan. Metode Immersive Experiential Learning melalui game simulasi MonsoonSIM sebagai alat bantu pembelajaran  yang terdiri dari Tahap Concrete Experience (Feeling), Reflective Observation (Watching), Abstract Conceptualization (Thinking), Active Experimentation (Doing) mampu memberikan kesempatan untuk berinteraksi dengan dunia nyata dalam lingkungan simulasi yang mirip dengan dunia bisnis sebenarnya yang secara signifikan meningkatkan pengetahuan siswa tentang kewirausahaan mulai dari analisis pasar, pengambilan keputusan bisnis, dan manajemen keuangan melalui pengalaman langsung dalam simulasi, serta berpengaruh positif pada sikap siswa dalam kewirausahaan, seperti motivasi, kemandirian, dan kreativitas. Berdasarkan hasil Evaluasi pelatihan menggunakan metode Kirkpatrick menunjukkan hasil yang positif. Pada Level 1, siswa menunjukkan respon positif mereka merasa terlibat dan antusias dalam menggunakan game simulasi MonsoonSIM. Pada Level 2, terjadi peningkatan yang signifikan dalam pengetahuan dan keterampilan siswa dalam kewirausahaan setelah mengikuti pelatihan ini. Pada Level 3, siswa berhasil mengaplikasikan keterampilan yang dipelajari dalam simulasi ke dalam konteks nyata, seperti merancang dan menjalankan bisnis kecil. Pada Level 4, terlihat adanya hasil positif dalam bentuk kesuksesan kewirausahaan siswa setelah pelatihan, seperti peningkatan pendapatan dan pengembangan usaha.
Membangun pendidikan multikultural melalui pendekatan inklusi dalam pembelajaran sosiologi
Authors: Pudyastuti Septina Galih , Trinugraha Yosafat Hermawan , Nurhadi  , Zuhri Saifuddin
Published: November 2023

Peningkatan kompetensi sebagai unsur profesionalitas guru tercermin dalam pembelajaran. Panduan kurikulum Merdeka membahas pendekatan inklusi sebagai wujud pendidikan multikultural. Inklusi merupakan strategi membangun lingkungan pendidikan yang setara bagi subyek pendidikan dengan perbedaan latar belakang dan kondisi. Mewujudkan pembelajaran Sosiologi dengan pendekatan inklusi masih menjadi kendala bagi sebagian guru MGMP Sosiologi di Surakarta. Kegiatan pengabdian ini berjenis research and development yang bertujuan memberikan pemahaman pendekatan inklusi melalui kegiatan sosialisasi. Salah satunya difasilitasi RG Habitus Pendidikan Sosiologi Antropologi UNS dengan menghadirkan seorang praktisi dan para guru yang tergabung dalam MGMP Sosiologi Surakarta. Produk luaran berupa representasi video pembelajaran di SMA N 8 Surakarta yang ditunjuk sebagai percontohan sekolah pendidikan inklusi di Surakarta. Video tersebut sekaligus sebagai bahan refleksi bagi guru dalam pembelajaran Sosiologi.
Kemitraan pengembangan pariwisata digital berbasis ICT
Authors: Ismandianto  , Muchid  , Handoko Tito , Heriyanto Meyzi
Published: November 2023

Kebijakan pengembangan pariwisata Kabupaten Kuantan Singingi tertuang dalam rencana pembangunan jangka menengah daerah Kabupaten Kuantan Singingi yang dituangkan dalam Peraturan Daerah Nomor 1 Tahun 2017. Saat ini komunitas wisata yang ada termasuk kelompok sadar wisata yang sudah mulai terbentuk di berbagai desa. Tujuan kegiatan pengabdian masyarakat untuk pengembangan potensi pariwisata di Kabupaten Kuantan Singingi melalui pelatihan dan pendampingan, berbasis ICT (Information and Communication Technologies) Sasaran adalah kelompok sadar wisata (Pokdarwis) khususnya bidang promosi UMKM, total keseluruhan sekitar 75 orang.  Tahapan kegiatan pengabdian yang dilakukan yaitu; pertama, Koordinasi dan perencanaan Kegiatan Pengabdian dengan mitra Dinas Pariwisata kabupaten Kuantan Singingi, Gerakan Pesona Indonesia (GeNpi) Kabupaten Kuantan Singingi, Mahasiswa Kukerta. Kedua, Pembekalan Tim Pengabdian Masyarakat dengan mahasiswa kuliah kerja nyata sebagai supporting system. Ketiga, pola pendampingan dan pelatihan anggota Keempat, monitoring dan evaluasi, Kelima, pembuatan sarana publikasi. metode yang digunakan adalah enthrepreneurship capasity building (ECB) dengan mengidentifikasi permasalahan pariwiata dan UMKM pada masyarakat Kecamatan Singingi dan Singingi Hilir melalui pelatihan dan pendampingan, berbasis ICT. Keberhasilan pengabdian tergambar dengan terciptanya media promosi wisata dan UMKM berbasis ITC.
Peningkatan pendapatan kelompok nelayan
Authors: Liniarti Sri , Nasution Rizky Surya Andhayani , Sihombing Panangian Mahadi
Published: November 2023

Nelayan adalah penduduk yang tinggal di pesisir Pantai dengan sumber pendapatan ekonomi bergantung pada sumber daya laut.Sehingga tingkat pendapatan nelayan relative rendah.Pengabdian ini bertujuan untuk memberikan pemahaman dan keterampilan kepada mitra UKM yaitu kelompok nelayan agar terjadi peningkatan dalam pendapatan mitra. Kegiatan ini dilaksanakan di Desa Perlis Kabupaten Langkat. Adapun metode dan tahapan pengabdian yang digunakan adalah Tahap desk study, tahap memberikan sosialilasi atau pelatihan dan penyuluhan langsung terkait manajemen bisnis tambak udang,pembukuan laporan penjualan hasil tangkap dan tambak,tahap penerapan teknologi pemasaran hasil tangkap dan tambak lewat E-Commerce dan pendampingan kepada mitra selama tambak udang berjalan tahap Evaluasi.Pengabdian berjalan selama 8 bulan terhitung April sampai November 2023.Peserta dari pengabdian ini yaitu Komunitas Nelayan yang berjumlah 10 orang. Hasil dari kegiatan pengabdian ini yaitu meningkatnya pengetahuan dan keterampilan mitra dalam penerapan manajemen bisnis yang baik serta tata kelola usaha,meningkatnya pengetahuan tentang teknik pemasaran ikan,udang baik dari hasil tangkap laut maupun tambak, tertibnya pengadministrasi keuangan  usaha mitra, sehingga pembukuan usaha mitra sudah tercatat dengan baik dan benar dan pengetahuan tentang regulasi pemerintah tentang perdagangan bisnis lewat branding dan ecommerce.
COUNSELING ON THE PREVENTION OF VAGINAL DISCHARGE IN ADOLESCENTS WITH PERSONAL HYGIENE AT HIDAYATUN NAJAH SAMIRAN VILLAGE PROPPO SUB-DISTRICT PAMEKASAN DISTRICT
Authors: Nuviana Safitri Nuviana Safitri , Emi Yunita Emi Yunita
Published: November 2023

women who experience vaginal discharge as much as 75%, mostly 50% occur in adolescents, 25% in women of childbearing age (WUS). Vaginal discharge in adolescents usually occurs before and after menstruation which is physiological. If the behavior of genital hygiene care is not good, it can be the cause of pathological vaginal discharge which causes discomfort and in the long term can cause pelvic infection and infertility. One of the factors inhibiting healthy behavior is the lack of knowledge and awareness of individuals about genital hygiene including the prevention and treatment of vaginal discharge. The purpose of this activity is to determine the relationship between the knowledge of adolescent girls about vaginal discharge and genital hygiene behavior. The targets of this activity are female students at Hidayatun Najah Mts, Samiran Village, Proppo District, Pamekasan. The evaluation provides an opportunity for female students to ask questions and provides an opportunity to explain again about vaginal discharge. Adolescent girls need to be given information on how to clean the reproductive organs properly and correctly. In addition, it is also necessary to encourage them to actively seek out information about reproductive health, especially providing lessons on genital organ care such as toileting techniques, using underpants that are not tight, changing underpants, and using non-perfumed soap.
The Historical Evolution of Russophilia in Europe: a Study of the Development and Transformation of Positive Attitudes Towards Russia
Authors: Jahangirli Jahangir , Jabarov Jahandar
Published: November 2023

The purpose of this paper is to investigate the historical trajectory, spread, and evolution of russophilia, a sociological phenomenon that exists in contemporary Europe. The article conducts a comprehensive analysis of the developmental process of russophilia in Europe, tracing its origins from the early stages of primitive sympathy towards the Russian state during the Middle Ages to its subsequent conscious ideological-cultural and political-economic manifestations in the 20th century. Furthermore, the article examines the contemporary projection of russophilia, which reached its pinnacle in the aforementioned region during the 20th century, while also exploring the factors contributing to the current decline of russophilia.

The article introduces a significant scientific contribution by being the pioneering study to comprehensively explore the historical evolution of russophilia in Europe. Previous research on russophilia has been limited in scope, with only a few articles addressing the topic in a fragmented manner. Prior to this article, there has been a lack of comprehensive studies examining the overall development of russophilia in Europe. Therefore, this article stands as the first comprehensive endeavor in this field of research, filling a notable gap in the existing literature.

Conclusions. The results of the study shed light on the origins and development of russophilia in Europe, examining both Western and Eastern regions. Key factors contributing to russophilia include the influence of communism, particularly the USSR, as well as cultural expansion. Effective propaganda campaigns and the establishment of economic and social connections play crucial roles in fostering admiration for another culture. Ethnic kinship alone is insufficient to foster deep affinity without widespread and systematic propaganda integrated into state policy. Nostalgia for communism, fuelled by shared experiences and the positive aspects of former communist systems, also contributes to russophilia. Countries such as East Germany, Poland, and Serbia etc., which underwent communist rule, exhibit heightened russophilia. The common fate shared by these nations, including the same political ideology, communist culture, and perceived defeat by the capitalist USA, further strengthens russophilia sentiments among communist nostalgics.
Антиукраїнська політика в історичній освіті України за міністра Д. Табачника (2010 – початок 2014 рр.)
Authors: Terno Serhii , Turchenko Galyna
Published: November 2023

Метою статті є аналіз антиукраїнської політики в історичній освіті за міністра освіти і науки України Д. Табачника (2010 – початок 2014 рр.). Дослідження ідеологічного наступу вкрай важливо для того, аби ідентифікувати та протидіяти подібним небезпекам у майбутньому. Задля цього було здійснено ретроспективний аналіз діяльності Д. Табачника та виділено етапи та методи його деструктивної діяльності.

Наукова новизна полягає у дослідженні антиукраїнської політики Д. Табачника в сфері історичної освіти. Виділено етапи деструктивної діяльності міністра освіти і науки, який всю силу адміністративного апарату держави спрямував на руйнацію української ідентичності передовсім в історичній освіті.

Висновки. В ході дослідження встановлено, що міністр освіти і науки України Д. Табачник за президентства В. Януковича здійснював системні заходи з нищення української національної ідентичності та впровадження в історичну освіту ідей «русского мира». З цією метою було проведено низку ідеологічних диверсій: 1) операція «спільний підручник з історії» для школярів (2010); 2) операція «спільний посібник» для вчителів історії (2010-2012); 3) перегляд навчальних програм з історії з метою деукраїнізації молодого покоління українців, що супроводжувалось вилученням з програм поняття «Україна», «українська держава» та історичних постатей Богдана Хмельницького, Тараса Шевченка, Михайла Грушевського, Івана Франка, Лесі Українки – символів України (2012); 4) суттєве скорочення часу на вивчення доленосних подій вітчизняної історії в пропедевтичному курсі історії; 5) перегляд програм Зовнішнього незалежного оцінювання та вилучення з них діячів Організації українських націоналістів С. Бандери та Р. Шухевича (2013); 6) введення до програми ЗНО радянських діячів Петровського, П’ятакова, Щорса, Хрущова (2013).

Діяльність міністра освіти і науки Д. Табачника нанесла значну шкоду історичній освіті України. Головна мета його дій полягала у розчиненні української ідентичності та нівелюванні національних цінностей. Молодому поколінню українців прищеплювалось зневажливе ставлення до своєї країни, її історії та культури. Натомість через насаджування меншовартості робились спроби включити Україну в орбіту «русского мира». Проте, антиукраїнська політика Д. Табачника наразилася на громадський супротив та не мала значного успіху.
Emerging technologies for engineering of extracellular vesicles
Authors: Zhou Xin , Huang Qing , Jiang Yang , Tang Huijing , Zhang Luhan , Li Danyang , Xu Yunsheng
Published: November 2023

Extracellular vesicles (EVs) are lipid-bilayer membrane-enclosed vesicles that are secreted by all cell types. Natural EVs contain biological information such as proteins, nucleic acids, and lipids from their parent cells. Therefore, EVs have been extensively studied as diagnostic biomarkers and therapeutic tools under normal and pathological conditions. However, some drawbacks, including low yield, poor therapeutic effects, lack of imaging, and targeting capacity of natural EVs, still need to be improved. Emerging engineering technologies have rendered EVs new properties or functionalities that broadened their applications in the biomedical field. Herein, in this review, we gave a brief overview of advanced strategies for EV engineering. We focused on pre-treatment of parent cells to regulate their released EVs. Meanwhile, we summarized and discussed the direct modification of EVs to achieve drug loading, imaging, and targeting functionalities for downstream applications.
Acute transplantation of NPC on electrospun poly-lactic acid membranes containing curcumin into the injured spinal cord reduces neuronal degeneration
Authors: Sánchez-Martín María del Mar , Giraldo Esther , Gisbert Roca Fernando , Alastrue-Agudo Ana , Martínez-Ramos Cristina , Monleón Pradas Manuel , Moreno-Manzano Victoria
Published: November 2023

Effective spinal cord injury (SCI) treatment remains a significant challenge, given the complex nature of the primary injury and associated devastating loss of neural activity. Neural progenitor cell (NPC)-based therapy has emerged as a potent strategy for the treatment of SCI. However, the invasive nature of direct cell transplantation and the need to enhance graft integration into host tissue remain critical issues. We implemented an improved combinatorial approach to SCI treatment by functionalizing electrospun poly-lactic acid (PLA) membranes that support the sustained delivery of curcumin (PLA-curcumin) and act as a carrier for NPC for local transplantation. In vitro experiments demonstrate that curcumin prevents harmful oxidative and inflammatory stress by preventing death and inhibiting NF-κB activation (mimicked by treatment with hydrogen peroxide or lipopolysaccharide acid). Curcumin also enhances neurite-like outgrowth in NPC and cortical neurons in culture, which may enhance neural connectivity. In vivo transplantation of NPC on a PLA-curcumin electrospun membrane enables cell migration, reduces injured area size, and increases neuronal fiber preservation to induce a slowing of acute neural damage.
Dual-purpose nanoparticle assembly for identifying preferential intracellular targets of oxindolimine copper(II) complexes through SERS imaging
Authors: Marin Jayr H. , Mamián-López Mónica B. , Da Silva Daniel R. , Temperini Marcia L. A. , da Costa Ferreira Ana Maria
Published: November 2023

In this study, the main goal was to identify the intracellular targets of oxindolimine copper(II) complexes by SERS and Raman imaging of living HeLa cells, whose action as a cancer inhibitor has been previously determined. The used SERS probe was constituted of spherical gold nanoparticles together with the Raman reporter 5,5′-dithiobis-2-nitrobenzoic acid (DTNB) and oxindolimine copper(II) complexes, [Cu(isatp)Cl] and [Cu(nisatp)H2O]. Two excitation radiations were used to acquire living single HeLa cells images: 532 nm to acquire the conventional Raman information of the cells and 785 nm to acquire the localization of the modified SERS probe inside the cells. The Raman images of the main intracellular components were obtained by multivariate analysis, and the SERS images were obtained by univariate analysis using a Raman reporter. The SERS and Raman images showed that the complexes could enter the cells together with the gold nanoparticles, causing main damage to the nuclei and lipids-rich region. In addition, there was no evidence of water entry into the cell.
Environmental characteristics and type 1 diabetes: students' perspectives on diabetes management in college
Authors: Malova Ekaterina , Harrison Tyler R.
Published: November 2023

Introduction

Type 1 diabetes is a chronic illness requiring immense lifestyle changes to reduce the chance of life-threatening complications, which can be especially challenging during the time of transition to college. This study applies a communication design perspective to explore how students with type 1 diabetes interpret their experiences in college and what meanings they attribute to those experiences. Specifically, this study sheds light on physical and social environmental components affecting students' diabetes management.

Methods

Study participants were recruited from the College Diabetes Network (CDN). A total of twenty students with type 1 diabetes participated in the study. A qualitative descriptive study design with an ethnographic interview approach was applied.

Results

Four cultural themes emerged from the analysis: (1) Food environment, (2) Structural environment, (3) Academic life, and (4) Social life. The findings illustrate how food outlets and food accessibility, safe spaces for insulin injections, comfortable living spaces, availability of health support services, and diabetes-friendly classroom regulations constitute a higher-level environmental system affecting students' wellbeing. They also highlight a complex relationship between structural barriers to diabetes management, health disclosure, and public stigma.

Discussion

Results from this study advance scholarship on diabetes care in the population of emerging adults by offering insights into how college students with T1D transition to college and manage type 1 diabetes. Overall, students with T1D have specific needs beyond those of the general student population. Thus, necessary modifications in the designs of existing structures should be introduced to facilitate students' assimilation into new organizational environments.
The politics between power and digital capital in China's cyberspace: a case study of Chinese digital games
Authors: Liu Juan
Published: November 2023

Based on a case study of digital games, this paper explores the politics between power and digital capital ingrained in the rapidly expanding Chinese cyberspace. The results show that digital capital and power in cyberspace form a paradoxical relationship that produces four sorts of politics: alliance, semi-alliance, disjunction, and semi-disjunction. Chinese modernity, as well as China's unique capital structure and governance system, have contributed to these politics. It is these politics that have given rise to a more decentralized regulatory system, brought freedom and autonomy to cyberspace, and maximized the Chinese government's power. Then digital capitalists in cyberspace can weave digital technology quickly into various social practices and make full use of netizens' creativity. Consequently, the politics between the Chinese government and digital capitalists in cyberspace not only triggered an unexpected social transformation but also opened up a different path for Chinese digital technology.
Older adults' perspectives on multimodal interaction with a conversational virtual coach
Authors: El Kamali Mira , Angelini Leonardo , Lalanne Denis , Abou Khaled Omar , Mugellini Elena
Published: November 2023

Introduction

The use of multiple interfaces may improve the perception of a stronger relationship between a conversational virtual coach and older adults. The purpose of this paper is to show the effect of output combinations [single-interface (chatbot, tangible coach), multi-interface (assignment, redundant-complementary)] of two distinct conversational agent interfaces (chatbot and tangible coach) on the eCoach-user relationship (closeness, commitment, complementarity) and the older adults' feeling of social presence of the eCoach.

Methods

Our study was conducted with two different study settings: an online web survey and a face to face experiment.

Results

Our online study with 59 seniors shows that the output modes in multi-interface redundant-complementary manner significantly improves the eCoach-user relationship and social presence of the eCoach compared to only using single-interfaces outputs. Whereas in our face to face experiment with 15 seniors, significant results were found only in terms of higher social presence of multi-interface redundant complementary manner compared to chatbot only.

Discussion

We also investigated the effect of each study design on our results, using both quantitative and qualitative methods.
Impact of periprocedural myocardial injury after transcatheter aortic valve implantation on long-term mortality: a meta-analysis of Kaplan-Meier derived individual patient data
Authors: de Sá Marchi Mauricio Felippi , Calomeni Pedro , Gauza Mateus de Miranda , Kanhouche Gabriel , Ravani Lis Victória , Rodrigues Caio Vinicius Fernandes , Tarasoutchi Flávio , de Brito Fábio Sandoli , Rodés-Cabau Josep , Van Mieghem Nicolas M. , Abizaid Alexandre , Ribeiro Henrique Barbosa
Published: November 2023

Background

Periprocedural myocardial injury (PPMI) frequently occurs after transcatheter aortic valve implantation (TAVI), although its impact on long-term mortality is uncertain.

Methods

We performed a pooled analysis of Kaplan-Meier-derived individual patient data to compare survival in patients with and without PPMI after TAVI. Flexible parametric models with B-splines and landmark analyses were used to determine PPMI prognostic value. Subgroup analyses for VARC-2, troponin, and creatine kinase-MB (CK-MB)-defined PPMI were also performed.

Results

Eighteen observational studies comprising 10,094 subjects were included. PPMI was associated with lower overall survival (OS) after two years (HR = 1.46, 95% CI 1.30–1.65, p < 0.01). This was also observed when restricting the analysis to overall VARC-2-defined PPMI (HR = 1.23, 95% CI 1.07–1.40, p < 0.01). For VARC-2 PPMI criteria and VARC-2 troponin-only, higher mortality was restricted to the first 2 months after TAVI (HR = 1.64, 95% CI 1.31–2.07, p < 0.01; and HR = 1.32, 95% CI 1.05–1.67, p = 0.02, respectively), while for VARC-2 defined CK-MB-only the increase in mortality was confined to the first 30 days (HR = 7.44, 95% CI 4.76–11.66, p < 0.01).

Conclusion

PPMI following TAVI was associated with lower overall survival compared with patients without PPMI. PPMI prognostic impact is restricted to the initial months after the procedure. The analyses were consistent for VARC-2 criteria and for both biomarkers, yet CK-MB was a stronger prognostic marker of mortality than troponin.
Case Report: A leadless and endovascular pacemaker teamwork
Authors: Zeriouh Sarah , Sousonis Vasileios , Menè Roberto , Boveda Serge , Voglimacci-Stephanopoli Quentin , Combes Stéphane
Published: November 2023

Background

Cardiac Implantable Electronic Device infections increase short- and long-term mortality, along with healthcare costs. Leadless pacemakers (PM) were developed to overcome pocket- and minimize lead-related complications in selected high-risk patients. Recent advancements enable leadless devices to mechanically detect atrial activity, facilitating atrioventricular (AV) synchronous stimulation.

Case summary

A 90-year-old woman, implanted with a dual-chamber pacemaker eight years ago due to sinus node dysfunction, presented with syncope. A diagnosis of complete AV block, in the setting of ventricular lead dysfunction was made. Due to a high risk of infection, the patient was implanted with a leadless PM capable of maintaining AV synchrony in VDD mode (MICRA™ model MC1AVR1). The transvenous PM was programmed to AAI-R mode to drive the atria, which, in turn, triggered the leadless PM to stimulate the ventricles. At six month follow-up, the AV synchrony rate was 85%.

Conclusion

The combination of classic atrial pacing with leadless ventricular stimulation can be used in high-risk patients to reduce the risk of complications, in the setting of ventricular lead dysfunction. In this manner, AV synchrony can be maintained, improving hemodynamic parameters and quality of life. Low sinus rate variability at rest is essential to achieve a high AV synchrony rate in such cases.
Comparative safety of different recommended doses of sodium–glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis of randomized clinical trials
Authors: Chen Lu , Xue Qingxia , Yan Chunyan , Tang Bingying , Wang Lu , Zhang Bei , Zhao Quan
Published: November 2023

Objective

The safety results of different recommended doses of sodium-glucose cotransporter 2 inhibitors (SGLT-2i) for patients with type 2 diabetes mellitus (T2DM) remain uncertain. This study aims to comprehensively estimate and rank the relative safety outcomes with different doses of SGLT-2i for T2DM.

Methods

PubMed, Embase, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Chinese National Knowledge Infrastructure, WanFang database, and SinoMed database were searched from the inception to 31 May 2023. We included double-blind randomized controlled trials (RCTs) comparing SGLT-2i with placebo or another antihyperglycemic as oral monotherapy in the adults with a diagnosis of T2DM.

Results

Twenty-five RCTs with 12,990 patients randomly assigned to 10 pharmacological interventions and placebo were included. Regarding genital infections (GI), all SGLT-2i, except for ertugliflozin and ipragliflozin, were associated with a higher risk of GI compared to placebo. Empagliflozin 10mg/d (88.2%, odds ratio [OR] 7.90, 95% credible interval [CrI] 3.39 to 22.08) may be the riskiest, followed by empagliflozin 25mg/d (83.4%, OR 7.22, 95%CrI 3.11 to 20.04)) and canagliflozin 300mg/d (70.8%, OR 5.33, 95%CrI 2.25 to 13.83) based on probability rankings. Additionally, dapagliflozin 10mg/d ranked highest for urinary tract infections (UTI, OR 2.11, 95%CrI 1.20 to 3.79, 87.2%), renal impairment (80.7%), and nasopharyngitis (81.6%) when compared to placebo and other treatments. No increased risk of harm was observed with different doses of SGLT-2i regarding hypoglycemia, acute kidney injury, diabetic ketoacidosis, or fracture. Further subgroup analysis by gender revealed no significantly increased risk of UTI. Dapagliflozin 10mg/d (91.9%) and canagliflozin 300mg/d (88.8%) ranked first in the female and male subgroups, respectively, according to the probability rankings for GI.

Conclusion

Current evidence indicated that SGLT-2i did not significantly increase the risk of harm when comparing different doses, except for dapagliflozin 10mg/d, which showed an increased risk of UTI and may be associated with a higher risk of renal impairment and nasopharyngitis. Additionally, compared with placebo and metformin, the risk of GI was notably elevated for empagliflozin 10mg/d, canagliflozin 300mg/d, and dapagliflozin 10mg/d. However, it is important to note that further well-designed RCTs with larger sample sizes are necessary to verify and optimize the current body of evidence.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023396023.
Effects of different volumes of ovariectomy on fertility and offspring development of rats
Authors: Yang Yu , Ruan Xiangyan , Cheng Jiaojiao , Xu Xin , Mueck Alfred O.
Published: November 2023

Objective

The purpose of this study was to explore the effect of removal of different volumes of ovarian tissue on fertility and offspring development of SD rats.

Methods

SD rats were randomly divided into 6 groups according to different volumes of ovariectomy: Sham group (n=6), non-ovariectomized; 25%-OVX group (n=6), with half of the left ovary excised; 50%-OVX group (n=5), with the left ovary excised; 75%-OVX group (n=5), with the left ovary and half of the right ovary excised; 87.5%-OVX group (n=6), with the left ovary and three quarters of the right ovary excised; 100%-OVX group (n=6), with bilateral ovaries excised. These female rats (F0) were mated with healthy male rats one and four months after the surgery, and the offspring of F0 rats were named F11mon and F14mon, respectively. The number of days from mating to delivery and number of live cubs were recorded. At postnatal day 21 (P21), the body weight, length and anogenital distance (AGD) of the cubs were measured.

Results

There were no differences in the number of live cubs between 25%-OVX, 50%-OVX and sham groups. Rats in the 87.5%-OVX group did not give birth at 1 month and 4 months after the operation. When compared with the sham group, the body weight and length of F11mon at P21 were increased in 25%-OVX group and 50%-OVX group. However, after the second delivery, we controlled each mother’s lactation to no more than eight pups. As a result, there were no differences in the body weight, length and AGD of F14mon compared with sham group.

Conclusion

Removal of less than 50% of the ovaries did not affect the fertility of rats and offspring development of rats.
Association between serum Klotho concentration and hyperlipidemia in adults: a cross-sectional study from NHANES 2007–2016
Authors: Yan Shaohua , Luo Wei , Lei Li , Zhang Qiuxia , Xiu Jiancheng
Published: November 2023

Objective

The Klotho protein is a well-documented anti-aging protein known for its diverse biological functions. Hyperlipidemia is an established independent risk factor for various chronic diseases. However, there is limited understanding of the connection between Klotho and hyperlipidemia. The aim was to assess the association between serum Klotho levels and hyperlipidemia among adults.

Methods

The study included 11,618 individuals from the NHANES database from 2006 to 2017. Hyperlipidemia was diagnosed following the National Cholesterol Education Program guidelines. Serum Klotho concentration was measured by an enzyme-linked immunosorbent assay kit, and the association between Klotho and hyperlipidemia was assessed by a multivariable logistic regression model. Fitted smoothing curves and threshold-effect analysis were employed to describe nonlinear relationships.

Results

In our multiple logistic regression models, serum Klotho concentration was significantly associated with hyperlipidemia after adjusting for comprehensive confounders (per SD increment odds ratio (OR): 0.91; 95% confidence interval (CI): 0.86–0.97). Compared to individuals in the lowest Klotho quartile, those in the highest quartile exhibited a substantially decreased prevalence of hyperlipidemia (OR: 0.72; 95% CI: 0.58–0.90). Using a two-segment logistic regression model, we identified a U-shaped relationship between serum Klotho concentration and hyperlipidemia, with an inflection point at 1,365.5 pg/mL. Subgroup analysis did not reveal any potential moderating effects.

Conclusion

This study revealed an inverse relationship between Klotho levels and hyperlipidemia. Further investigation is warranted to explore the underlying mechanism between serum Klotho and hyperlipidemia.
Causal association between lipid-lowering drugs and female reproductive endocrine diseases: a drug-targeted Mendelian randomization study
Authors: Zhao Jing , Wang Runfang , Song Liyun , Han Hua , Wang Pei , Zhao Yuan , Zhang Yunxia , Zhang Hongzhen
Published: November 2023

Purpose

The relationship between dyslipidemia and female reproductive endocrine diseases has been increasingly studied. The use of lipid-lowering drugs in treating various related diseases, including coronary heart disease, may affect female reproductive endocrine diseases. Therefore, our study aims to investigate the effects of lipid-lowering drugs on female reproductive endocrine diseases and provide a basis for the appropriate selection of drugs.

Methods

In this study, we focused on three drug targets of statins, namely HMG-CoA reductase (HMGCR) inhibitors, proprotein convertase kexin 9 (PCSK9) inhibitors, and Niemann–Pick C1-Like 1 (NPC1L1) inhibitors. To identify potential inhibitors for these targets, we collected single nucleotide polymorphisms (SNPs) associated with HMGCR, PCSK9, and NPC1L1 from published genome-wide association study statistics. Subsequently, we conducted a drug target Mendelian randomization (MR) analysis to investigate the effects of these inhibitors on reproductive endocrine diseases mediated by low-density lipoprotein cholesterol (LDL-C) levels. Alongside coronary heart disease as a positive control, our main outcomes of interest included the risk of polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), premenstrual syndrome (PMS), abnormal uterine bleeding (including menorrhagia and oligomenorrhea), and infertility.

Results

PCSK9 inhibitors significantly increased the risk of infertility in patients (OR [95%CI] = 1.14 [1.06, 1.23], p<0.05). In contrast, HMGCR inhibitors significantly reduced the risk of menorrhagia in female patients (OR [95%CI] = 0.85 [0.75, 0.97], p<0.05), but had no statistical impact on patients with oligomenorrhea.

Conclusion

The findings suggest that PCSK9 inhibitors may significantly increase the risk of infertility in patients. On the other hand, HMGCR inhibitors could potentially offer protection against menorrhagia in women. However, no effects of lipid-lowering drugs have been observed on other reproductive endocrine disorders, such as PCOS, POF, PMS and oligomenorrhea.
Virtual impedance based low-voltage distribution grid topology detection using double hidden layer recurrent neural network
Authors: Xuan Yi , Sun Zhiqing , Fan Libo , Chen Yixuan , Han Rongjie , Wang Qifeng , Huang Jiabin , Jin Minhao
Published: November 2023

Low-voltage distribution grid (LVDG) topology detection refers to detecting whether the topology connection between distribution grid nodes is correct. Accurate topology connection is critical for the normal operation and planning of LVDG. However, due to the incomplete measurement device, unknown line parameters, and rapid growth of renewable energy, the topology detection of LVDG becomes one of the most prominent challenges. This paper proposes an LVDG topology detection method based on virtual impedance, utilizing measurement data from nodes in the LVDG to achieve the detection of abnormal topological connections. Specifically, the electrical distances between nodes are analyzed to establish a topology detection model using virtual impedance. Then, the double hidden layer recurrent neural network is proposed to fit the mapping relationships between variables in the power flow constraints. The virtual impedance between nodes is solved. The value of virtual impedance is used to determine whether the topological connection between nodes is correct. Finally, the test results in the actual LVDG prove the effectiveness of the proposed method.
Regional outburst prevention technology of pre-drainage gas area in west well area of sihe coal mine
Authors: Zhang Peng
Published: November 2023

Coal and gas outburst is one of the main factors affecting the safe and efficient production of coal mines. With the increase of mining depth and mining speed, the dynamic phenomena of coal and gas outburst will become more and more serious. Through the study of various outburst prevention measures in the pre-drainage gas area such as surface drilling, bedding (directional) drilling, and cross-layer drilling, combined with the coal seam occurrence and mining technology of the West Mine Area, a feasible regional pre-drainage comprehensive outburst prevention mode suitable for the characteristics of the 3# coal seam in the West Mine Area has been obtained. This mode is based on pre-pumping of surface drilling first, directional long borehole along the reservoir and pre-pumping of cross-zone borehole, which provides reliable guarantee for safe and efficient production in outburst well area.
Effect of Rhodococcus bioaugmentation and biostimulation on dibenzothiophene biodegradation and bacterial community interaction in petroleum-contaminated soils
Authors: Chen Wenjie , Zuo Yilin , Hou Zhuonan , Wang Bo , Xiong Shangao , Ding Xiaoyan , Peng Bihui , Zhou Kaiyun , Li Ji , Liu Rui , Ding Guochun , Wei Yuquan , Xu Ting
Published: November 2023

Bioremediation can be effective method for achieving polycyclic aromatic hydrocarbons (PAHs) degradation in soil contaminated with petroleum. The aim of this study was to compare the effect of Rhodococcus bioaugmentation (BIOE) and biostimulation (BIOS) on dibenzothiophene biodegradation and bacterial community interaction in petroleum-contaminated soils. The findings revealed that compared to natural degradation treatment (NAT) and BIOS, BIOE had the highest dibenzothiophene (DBT) and the majority of DBT degradation occurred within the first 30 days. BIOS had a positive impact in the early stage but an opposite effect in the later stages for degrading DBT. Beta diversity analysis revealed significant differences of bacterial composition among NAT, BIOS, and BIOE. Sequencing results indicated that Bacillus and Paenibacillus were dominant genera involved in DBT degradation. Network analysis revealed co-occurrence patterns and connectivity, with BIOE exhibiting higher connectivity and the highest number of links in BIOS. In summary, Rhodococcus bioaugmentation was the simplest and effective method to enhance the clustering degree of bacterial network and DBT degradation in petroleum-contaminated soil, compared to NAT and BIOS.
The green GDP accounting system based on the BP neural network: an environmental pollution perspective
Authors: Zhu Yinglun , Xu Yingying , Luo Yuhui
Published: November 2023

Introduction: The green GDP accounting system has become the focus of sustainable development, but a comprehensive accounting of environmental pollution cost and resource depletion cost has not yet been formed.

Methods: This study measures environmental pollution cost and resource loss cost, and establishes the green GDP accounting system based on the SEEA-2012. To analyze the environmental effects brought by the adoption of green GDP accounting system, a BP neural network model including green GDP, traditional GDP and global climate indicators is constructed to predict the global climate changes.

Results: The empirical results show that after the adoption of the green GDP accounting system, the global climate extreme weather can be reduced, the sea level will be lowered, and the climate problem is thus alleviated.