bluuebunny/crossref_metadata_2025 huggingface dataset:
Diabetic patients need higher furosemide doses: a report on acute and chronic heart failure patients
Authors: Cunha Filipe M. , Pereira Joana , Marques Pedro , Ribeiro Ana , Bettencourt Paulo , Lourenço Patrícia
Published: November 2019

Introduction

Diuretics are first-line drugs in symptomatic heart failure treatment. Diabetes mellitus has been suggested as a determinant of diuretic resistance. Studies comparing the dose and efficacy of diuretics in patients with and without diabetes are lacking. We aimed to study if furosemide dose differed according to diabetes status.

Methods

We studied two cohorts of heart failure patients: a cohort of acute heart failure patients consecutively hospitalized with the primary diagnosis of heart failure and another of stable and optimized patients followed in a heart failure clinic. Data on comorbidities and medication were abstracted from patients’ files. Use and doses of furosemide were compared between diabetic and nondiabetic patients. Regression analysis was used to determine the association of variables with diuretic dose. The independent association of diabetes with furosemide dose was assessed using multivariate models.

Results

We studied 865 heart failure patients: 601 acute heart failure patients and 264 chronic stable heart failure patients. Acute heart failure patients with diabetes were more likely to need intravenous diuretic therapy and they were also more often discharged under higher doses of furosemide. They needed extra 6-mg furosemide at discharge in comparison with their nondiabetics counterparts and had an independent 26% higher odds of being discharged with at least 80-mg furosemide. Chronic patients were also more frequently prescribed with furosemide and on higher doses, although, diabetes was not independently associated with the use of higher furosemide doses.

Conclusion

Diabetic patients are more intensively treated with the loop diuretic furosemide. In acute heart failure, diabetes is an independent predictor of furosemide dose.
Estetiska dimensioner i svenskämnets kursplaner från Lgr 69 till Lgr 11
Authors: Dahlbäck Katharina , Lyngfelt Anna
Published: November 2019

The possibilities young pupils have to express themselves by using verbal, written and aesthetic languages depend on the multilingual discourse at school. In this presentation, multilingualism is defined as languages with roots in different nations and cultures, linked to aesthetic languages (music, fine arts, literature, theatre, film and dance). The term multimodality is used to highlight the variety of communicative forms used by people to utilize and develop knowledge (Selander & Kress, 2010). Although people increasingly communicate by the use of different modalities in today’s society (Kress, 2003), the written language holds a unique position in Swedish as a school subject, and the aesthetic means of expression could be said to be marginalized. The study presented is a qualitative, comparative study based on close reading of curricula for the subject Swedish from 1969 (Lgr 69) to 2011 (Lgr 11). The purpose is to make clear how aesthetic perspectives of Swedish appear in the different curricula, starting with the didactic questions on what students are expected to learn, how this is told to be executed and why. Among the analysed curricula, the curriculum from 1980 (Lgr 80) represents an empirical, multimodal, communicative, democratic and creative approach to the subject Swedish, where aesthetic forms of expressions are emphasized. The analysis shows that the importance of these communicative forms is reduced in later curricula, leaving the aesthetical aspects in the background. The possibilities represented by a variety of modalities and sign systems decrease. Instead a skill oriented school subject increase that weakens the bridges between different expressions of multilingual language. The discussion, has a focus on the problems that the curriculum implicates, when young, multilingual students are not given the possibilities to use their different sign systems and communicative capacity, and therefore not the possibility to learn with their full potential.
Pilot trial results in assessing english literacy of applicants to medical residencies
Authors: Sanabria Rivera Luis Eduardo , Polo Ledezma Reinaldo Emilio , Ramírez Cuellar Adonis Tupac
Published: November 2019

Objective. The main goal of this paper is to statistically describe the results obtained by 355 applicants to medical residencies, after responding a technical English test with 24 exercises. Justification. English is indispensable for reading, understanding specialized medical texts, for listening podcasts with the last scientific and technological advances in Medicine, and for writing and communicating medical reports.

Main Results. From 355 applicants to medical residency only seven have the necessary com­petences in Medical English to be a postgraduate student. The majority of aspirants have problems related with bad english competences in the act of correct managing of verb ten­ses, medical vocabulary, semantics and English syntax.
Investigación y creatividad
Authors: Torres Soler Luis Carlos
Published: November 2019

La creatividad es un recurso natural que posee el ser humano, que impulsa a investigar, a ser curioso, observador, a reflexionar ya cuestionarse continuamente, pero debe desarro­llarse, es decir, practicarse. Diversas actividades realiza el ser humano en su diario vivir. En algunas debe aplicar un método con el fin de genera, un pensamiento crítico, reflexivo y sistémico. Algunas requieren amplio conocimiento, pero otras exigen mayores capacidades para observar los elementos y relaciones que se hallan ocultas en un todo. La creatividad se emplea en un proceso de investigación, a fin de generar conocimiento para la sociedad; es la capacidad que ayuda a cuestionarse, a pensar ya ser mas curioso; tener propósitos para desarrollar mecanismos para una mejor calidad de vida.
Coherencia y pertinencia del modelo pedagógico de los docentes del programa de pedagogía infantil, de la facultad de educación de la universidad Surcolombiana en Neiva
Authors: Perdomo Cruz Emperatriz
Published: November 2019

La educación es el medio por el cual se han generado los procesos de transformación más importante de la sociedad; uno de los agentes de cambio es el docente y quíen más relevan­cia tiene en este proceso transformador, par cuanto incide directamente en el estudiante para el cambio a través del pensamiento critico o para transmisión y reproducción del status de desigualdad e injusticia social. Para Carry Kemmis (1988) ", "la educación deberia ser­vir para conseguir la emancipación coma tarea fundamental del hombre y lograr su pleno desarrollo''. Los problemas sociales, politicos, económicos en Colombia son bastante com­plejos, y frente a esta realidad, las instituciones de educación superior y sus modelos peda­gógicos, al parecer, nose han replanteado de forma que generen procesos de pensamiento criticos en torno a una educación integral del hombre, que responda de manera pertinente desde la educación a los problemas que aquejan a la nación colombiana.
Evaluación de la implementación de la política pública de primera infancia en la modalidad de entorno institucional en el municipio de Neiva
Authors: Córdoba Muñoz Laura
Published: November 2019

La Primera lnfancia, comprendida entre los cero y los seis años, es una etapa en la que tanto los niños como las niñas requieren estimulación, atención y tratamiento especiales que les permita desarrollarse biológica, psicológica, cultural y socialmente. Diversos estudios reali­zados desde distintas disciplinas han comprobado con argumentos sólidos que desde su concepción los niños cuentan con una serie de capacidades físicas, psicológicas, emociona­les y sociales que facilitan el aprendizaje, la socialización y la comunicación.
The Effectiveness of Chloramphenicol In-Situ Opthalmic Gel with Base Poloxamer 407 and HPMC Against Staphylococcus Aureus Atcc 29213 And Pseudomonas Aeruginosa Atcc 27853
Authors: Kurniawansyah Insan Sunan , Putriana Norisca Aliza , Kusuma Agung Fitri , Lee Tan Mei
Published: November 2019

Introduction: In-situ gel is a simple liquid transparent polymer solution under storage conditions, but turns into a viscoelastic gel after entering the eye due to the phase transition properties of the polymer that increase the residence time in ocular organ and bioavailability, enabling the delivery of reproducible doses and improving patient compliance. The aim of the present study was to formulate and evaluate the antibacterial effectivity of chloramphenicol in-situ ophthalmic gel with base poloxamer 407 and HPMC base against Staphylococcus aureus and Pseudomonas aeruginosa. Material and Methods: The optimization of ophthalmic gel preparation by the factorial design method has been carried out in order to know the best formula of all the formulas employed with 0.5% chloramphenicol active substance, wherein each formula was obtained from high concentration and low concentration of each base. Results: The measurement of the antibacterial effectivity against Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa ATCC 27853 by oneway ANOVA analysis showed that formula with base poloxamer 407 5% (F1) gave the best result. F1 has a dilute consistency, clear and stable during 28 days storage time when effectiveness test performed. Conclusions: Chloramphenicol in-situ gel with base poloxamer 407 and HPMC were effective against Staphylococcus aureus ATCC 29213 with intermediate to sensitive category, and Pseudomonas aeruginosa ATCC 27853 with sensitive category in accordance to the requirements of the Clinical and Laboratory Standards Institute (CLSI).
Formulation of Topical Gel from Extract of Berberis aristata DC for Acne
Authors: Prasad Shyam Baboo , Kaur Darshpreet , . Yashwant
Published: November 2019

In current study, an attempt has been taken to formulate Topical gel of ethanolic extract of Berberis aristata DC for antiacne activity. The gel containing extract was prepared by adding gel-forming material in sterile distilled water while the mixture was stirred and allowed to stand to hydrate. Extract was added in PEG 400 and polyethylene glycol mixture. Methyl paraben and propyl paraben were added as the preservative and triethanolamine was added as the neutralizer. The anti-acne activity was investigated against two causative bacteria, i.e., Propionibacterium acnes and Staphylococcus epidermidis and yeast (Malassezia furfur) by the well diffusion method. The result showed that gel passes all test of evaluation and was found to be active against acne causing microorganisms. Extract based gel has potential activity against acne-causing microorganism.
Biomedical Potential of Graphene oxide based Nanoformulations: An Overview
Authors: Mishra Vijay , Yadav Nishika , Singh Gurpal , Barnwal Ravi Pratap , Singla Neha , Prabhu Kirti. S. , Suttee Ashish
Published: November 2019

Graphene oxide is graphene-based two dimensional material and structure based on single sheet of carbon atoms arranged in hexagonal lattice or honeycomb framework. Graphene oxide is better than graphene in terms of dispersion in polar solvents due to oxygen-containing functional groups attached with carbon sheets, results as researchers to get indulged in this molecule. Graphene oxide has been attracted researchers in different fields like chemistry, physics and materials science. Graphene oxide has endless potential applications in building materials, environmental protection, electronics, medicine, pharmaceutical industries etc. In medicinal industry, graphene oxide used as antibacterial, antimicrobial and antifungal agent. Its potential activity with other nanoparticles as antifungal agent has come in light and became the main focus of going on works on graphene oxide. The antifungal property of GO-Ag composites was investigated. Furthermore, nanoparticles show great potential in the fields of biomedical, because of their antifungal properties. The GO-Ag composites act as alternative antifungal material. Moreover, antifungal activity of Reduced Graphene Oxide (rGO) nanosheets is also researched.
Glibenclamide-Nicotinamide Cocrystals Synthesized by The Solvent Evaporation Method to Enhance Solubility and Dissolution Rate of Glibenclamide
Authors: Budiman Arif , Apriliani Ayu , Qoriah Tazyinul , Megantara Sandra
Published: November 2019

Purpose: To develop glibenclamide-nicotinamide cocrystals with the solvent evaporation method and evaluate their solubility and dissolution properties. Methods: Cocrystals of glibenclamide-nicotinamide (1:2) were prepared with the solvent evaporation method. The prediction of interactive cocrystals was observed using in silico method. The solubility and dissolution were performed as evaluation of cocrystals. The cocrystals also were characterized by differential scanning calorimetry (DSC), infrared spectrophotometry, and powder X-ray diffraction (PXRD). Result: The solubility and dissolution profile of glibenclamide-nicotinamide cocrystal (1:2) increased significantly compared to pure glibenclamide as well as its physical mixture. Characterization of cocrystal glibenclamide-nicotinamide (1:2) including infrared Fourier transform, DSC, and PXRD, indicated the formation of a new solid crystal phase differing from glibenclamide and nicotinamide. Conclusion: The confirmation of cocrystal glibenclamide-nicotinamide (1:2) indicated the formation of new solid crystalline phases that differ from pure glibenclamide and its physical mixture
Effect of fenugreek (Trigonella foenum graecum) seed aqueous extract on blood glucose, lipid profile and some hormonal assay in Streptozotocin induced diabetic male albino rats.
Authors: Chalabi Salah M.M. Al , Abdul-Lattif Rashaa F. , Mahdawi Ferial A. Al , Abud Haylim N.
Published: November 2019

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia over a prolonged period, since a long time, diabetes has been treated with plant medicines, one of these important plant is Trigonella foenum-graecum (fenugreek), thus, the investigation goals of this study to clarify the role of fenugreek seed aqueous extract in its therapeutic dose on blood glucose , triglycerides, total cholesterol, lower density lipoprotein( LDL), higher density lipoprotein (HDL),very lower density lipoprotein( VLDL), liver and kidney function by estimating alanine aminotransferase (ALT), aspartate aminotransferase (AST), Blood Urea and serum creatinine, also to clarify the role in treatment of infertility by estimating Lutilising hormone (LH), Follicle stimulating hormone (FSH ), testosterone hormone level, sperm count, motility and viability in Stereptozotocin induced diabetes rat for 4-weeks of treatment , 60 adult male albino rats were divided into 4-groups (15 rat for each group), control (normal rats received normal saline), diabetic rats without treatment ,diabetic rats were treated with 300 mg /kg of methanolic plant extract for 4-weeks, diabetic rats treated with 650mg/kg of metformin drug. The result indicated that after 4- weeks of treatment of fenugreek seed aqueous extract, there was an improvement in blood glucose, lipid profile, liver and kidney function. Although there was an improvement in LH, FSH, testosterone hormone, sperm count , viability and motility.
Bacteriological Study of Pseudomonas aeruginosa Isolated from Tonsillitis Patients
Authors: Oda Alquraishi Zahraa Hameed , Ameer Al-Kraety Israa Abdul , Alsadawi Aqeel A.
Published: November 2019

Present study included (50) clinical samples were collected from patients suffering from tonsillitis signs during the period from) November 2018 to January, 2019). All specimens were cultured for microscopic and microscopic study.
Results show that from 50 patients, male was 60% and 40% were female. Several morphological, physiological and biochemical tests showed that P. aeruginosa constituted 18 isolates (36%) of these isolates. P. aeruginosa isolates were 18 isolates diagnosed by the morphological ,cultural and biochemical characters, the identification was confirmed by automated VITEK-2 compact system and molecular method for the presence of OprL.
The results showed that only 12 (66.6%) isolates diagnosed as P. aeruginosa by automated VITEK-2 compact system and that was carrying OprL which are diagnosed as P. aeruginosa by P.C.R. According to the different diagnostic above, VITEK and PCR method were more sensitivity for P. aeruginosa detection among tonsillitis patients
Personalized medicine: An overview
Authors: Mishra Vijay , Chanda Puja , Tambuwala Murtaza M. , Suttee Ashish
Published: November 2019

Personalized medicine is a model for health care which is a combination of preventive, personalized, participatory and predictive measures. It is an approach for better treatment by identifying the disease causing genomic makeup of an individual. Personalized medicine is a broad field and it can be used for the diagnosis of various diseases like cancers, Alzheimer, Hepatitis, Cardiac diseases etc. It is an emerging field with lots of hope in the future. This review is basically based on characteristics of personalized medicine and its implementation in various diseases like lung cancer, renal cancer and rheumatoid arthritis. Further, the initiation taken by the European Union towards the development of personalized medicine and the challenges faced during the data collection, development of medicine and clinical trials were also discussed. The personalized medicine coalitions (PMC) have approved various novel medicines as personalized medicine under US FDA.
Assessment the Incidence of Transitional Cell Carcinoma (TCC) of the Bladder Cancer
Authors: Al-Thuwaini Mahdi M , Enayah Sabah H , Ali Alwzy Mohammed Abdul Azeez , Husieen Hafeh Alyaa Abed_Al
Published: November 2019

Background: Transitional cell carcinoma (TCC) of the bladder is the second most common malignancy of the genitourinary tract and the third most common cause of death among people with genitourinary tumors, besides, tumors of the bladder are an important source of both morbidity and mortality. Objectives: The purpose of the study are 1. formulate an idea about the number of patients with bladder cancer (TCCs) in sample of Iraqi population. 2. Study the histopathological features of TCCs of bladder 3. Assessment the prevalence of (TCC) of bladder in both sex (male and female) with smoking as risk factor. Patients and Methods: A study was conducted at one institution were identified that teaching-hospital of Baghdad. All patients included in the present study diagnostic with TCC of bladder. The total of subjects participated in the study were 42 patients and 20 subjects as control through six months’ period from July 2014 to January 2015. Results: The mean of participates age was 655.7 years and the youngest was 21years and the oldest was 75 years. Out of 42 patients, the most common age group was 54-64years (52.38%) with Male to female ratio was 5.2:1.32 were male 32 and 10 were females. However, the prevalence bladder cancer (TCCs) was higher in male than in female, with more pronounced decreases in younger age (≤31year) 3(7.14), have been found. In addition, age specific rate was observed higher in the older age groups for most patients with cancer. The population attributable risk for ever smoking in our study was 33(78.57) out of 42 patients. Moreover, current study shows there was a correlation between grade and stage of bladder TCC, 24(57.14%) bladder TCCs that classified as grade I, while 2(4.76%) of bladder TCC were classified as grade II. Conversely, of the bladder TCC lesions (11.9%, 14.28%, 57.14 and 4.76) were stage (pTa-T1-T2-T3) respectively. Although this study showed 5(11.9) little-known stage and grade. The area of histopathological changes included were showed hyperplastic changes, involving the entire bladder lining, that ranged from flat hyperplasia to small areas of nodular and papillary hyperplasia. The smallest recognizable nodular and papillary lesions were associated with angiogenesis in the contiguous stroma. In addition, there were chromatin irregularities and nucleoli of variable numbers, shape and size. Nuclear chromatin irregularity and mitoses were easily identified, these cells continued to have the appearance of hyperplastic epithelium. The changes noted by generalized and orderly proliferative reaction and appeared reparative. Conclusions: Our study has revealed that the bladder TCC, where appeared the high prevalence and incidence rate of TCC of bladder in sample of Iraqi population were of concern, especially for older age groups.
Antibacterial activity of magnesium oxide nanoparticles prepared by Calcination method
Authors: Kadhem Elaf Ayad , Zghair Miaad Hamzah , Mahdi Sarah  , Hussam H. Tizkam, Shoeb Alahmad Salih , Tizkam Hussam H. , Alahmad Shoeb
Published: November 2019

magnesium oxide nanoparticles (MgO NPs) were prepared by simple wet chemical method using different calcination temperatures. The prepared NPs were characterized by Electrostatic Discharge (ESD), Scanning Electron Microscope (SEM) and X-ray Diffraction (XRD). It demonstrates sharp intensive peak with the increase of crystallinty and increase of the size with varying morphologies with respect to increase of calcination temperature. Antibacterial studies were done on gram negative bacteria (E.coli) and gram positive bacteria (S.aureus) by agar disc diffusion method. The zones of inhibitions were found larger for gram positive bacteria than gram negative bacteria, this mean, antibacterial MgO NPs activity more active on gram positive bacteria than gram negative bacteria because of the structural differences. It was found that antibacterial activity of MgO NPs was found it has directly proportional with their concentration.
Defensive activity of Hesperidin against Ciprofloxacin induced hepatic injury in rabbits.
Authors: Murad Hawraa M. , Hussein Tamadhur Hani , Khudhair Audai Sulaiman , Murad Manal Muhi , Faris Jawad Kadhim
Published: November 2019

This study was conducted to find out hepatoprotective activity of hesperidin (HES) 100mg/kg body weight (b.w.) against ciprofloxacin (CPX) 100 mg/kg induced hepatotoxicity in local breed rabbits .CPX is a broad spectrum antibiotic used for treatment of many bacterial infections. Twenty four male rabbits were divided into four groups ,group1: control, (1 ml/kg Saline orally) group 2: CPX (100 mg/kg orally) for (14) consecutive days , group 3: HES (100 mg//kg) orally for (14) consecutive days group 4: CPX (100 mg/kg orally) plus HES (100 mg//kg orally ) for (14) consecutive days. All the rabbits were killed on the (15) day of the experiment, and then the blood, and livers samples were taken. CPX induced hepatotoxicity was proved by a significant (p less than 0.01) reduction in the body weight ,and a significant (p less than 0.01) increased serum aspartate transaminase (AST), alanine transaminase (ALT) , Malonaldehyde enzyme (MAD) and histopathological changes. Protective hepatic toxicity effect and oxidative damage caused by CPX significantly (p less than 0.01) increasing in body weight and significantly (p less than 0.01) decreasing AST , ALT, MAD and improving tissue morphology in HES (100 mg//kg) . These results assure that HES (100 mg//kg) antioxidant effects can protect CPX-induced hepatotoxicity in rabbits.
Prevalence of Diabetes Mellitus and It’s Complications in Iraq
Authors: Fadheel Qayssar Joudah
Published: November 2019

Diabetes mellitus is a chronic metabolic disease characterized by long term elevation of blood glucose levels. A number of reasons that increase blood glucose level include (not enough insulin or oral diabetes drugs,too much food, adverse effects from other drugs, such as steroids, or conditions such as stress ,long- or short-term pain ,menstrual periods, dehydration). Objective: To assess the prevalence of type11 diabetic mellitus and its complications and comparison between different complications among people in Iraq. Patient: This is a randomize prospected, clinical study it was
carried out in Iraqi Hospitals, Department of Medicine, emergency. This study was started at December 2016, this approved medical ethical community at University of Kufa. Methods: Sample of 100 cases (50 male and 50 female) in Iraq was selected in random manner and all the patients found in the Iraqi Hospitals at the time of visiting. Where directly meet the patients and collect data from each patient according to specific questionnaires: weight, height and blood glucose level were obtained. Materials: Blood glucose level was measure by using specific device and must keep it in suitable place with maintenance of sterility and recalibration. Further advices were taken from Departments of clinical/biomedical engineering and Local medical physics. Results: The prevalence diabetes mellitus complications among the study populationwas as follow:-(Diabetic neuropathy 98%), (Diabetes retinopathy 96%), (stroke 60%), (Diabetic nephropathy 36%), (Hypertension 63%), (foot problems 60%). A significant difference was founded between some diabetic complications, these were (Neuropathy and hypertension), (Retinopathy and hypertension), (Retinopathy and stroke), (Nephropathy and hypertension), (Nephropathy and Stroke), (Hypertension and Foot problems), (Foot problem and stroke), (Neuropathy and stroke). Conclusion: The prevalence of diabetes mellitus complications was lying within that reported in Iraq. There was a significant difference recorded between some diabetic mellitus complications. Early diagnosis of diabetes mellitus and make program to the patient about lifestyle behavior were highly considered.
Technology Transfer in Pharmaceutical Manufacturing - A Review
Authors: Patil Amit B , B Bharath Kumar , Karnalli Ajay P
Published: November 2019

Technology Transfer (TT) is vital action from drug development in Research and Development (R and D) Department to commercial manufacturing till the product discontinuation. This review is an attempt to give an insight about the transfer of pharmaceutical product from R and D to production including necessary documents required to review the supporting documents and execution procedures in production shop floor. TT is considered effective, if there is a documented evidence that the process and its parameters, repeatedly results in desired product quality which was established upon during TT between the transferee and transferor. For the execution of TT process, expertise from different department such as Engineering, R and D, QA, process analyst and production are teamed. the transmission comprises of arrangements procured
in these flows of improvement to achieve the quality as planned throughout manufacture.
Relationship Between Chordin Like-1 Protein Level and Patients with Pulmonary Arterial Hypertension Disease
Authors: Al-Dujaili Arshad Noori Ghani , Al-Dujaili Mohammed Noori , Al-Khafaji Khamaal Hussein Abod
Published: November 2019

Pulmonary arterial hypertension (PAH) is a serene executioner, which can incite irreversible changes in pneumonic
vascular structure and point of confinement, developing pulmonary vascular resistance (PVR), right ventricular disappointment, and death. Background and Objective: This study was done at the Cardiac Centre of Al-Sader Medical City Hospital in Al-Najaf Al-Ashraf province for the period from December 2016 to May 2017 to investigate the level of biomarker of Chordinlike-1for patients with pulmonary arterial hypertension as predictive indicators of the disease for detection, diagnosis and early treatment of patients. Materials and Methods: The study was applied on 88 people aged 30-69 years; 67 patients group with pulmonary arterial hypertension (PAH) and 21 healthy group. The group of patients was divided into subgroups based on gender, age, body mass index (BMI), waist circumference, smokers and non-smokers,type of primary and secondary arterial hypertension, types of secondary arterial hypertension, and disease grade. The healthy group was divided according to gender and age. Results The study emerged a significant decrease (p less than 0.05) in the level of Chordin like-1 in the group of pulmonary arterial hypertension patients compared to the healthy group, the female group compared to the males, the age group at the age of 30 to 69, Secondary compared with a primary and the disease grade group was found that sever lower than moderate and mild.While the level of Chordin like-1 in the healthy group divided by gender and age have no significant differences.The study produced that in comparing secondary PAH types, there was a significant decrease (p less than 0.05) in the level of Chordin like-1 for both COPD and Left Heart Disease systolic dysfunction or diastolic dysfunction (LHD sys or dia) compared with Valvular, Congenital, and Pulmonary embolism. While there was no significant difference in the level of Chordin like-1between Valvular, congenital and pulmonary embolism. The study revealed no significant difference in the level of Chordin like-1 for the patients group of pulmonary arterial hypertension divided according to BMI group (normal weight, overweight, obese weight), waist circumference group (70-80 cm, 81-90 cm, 91-100 cm, 101-110 cm, 111-120 cm) and the group of smokers compared to non-smokers. conclusion: The biomarker Chordin like-1consider cautioning sign as a prognostic marker for determination PAH patients.
Electroencephalogram and Visual Evoked Potential Studies in Patients with Stroke
Authors: AL- Nasriwy Sura ZaKi Gaffat , Abbas Farah Nabil , Al bermany Abdul- Kareem , Al-Himyari Fizel Abbas , Abbas Farah Nabil
Published: November 2019

Stroke or cerebrovascular accident occurs when the blood supply to the brain is cut off (an ischemic stroke) or when a blood vessel bursts (a hemorrhagic stroke). Most strokes are of the ischemic type. Without oxygen, brain cells begin to die. death or permanent disability can result. High blood pressure, smoking,D.M, and having had a previous stroke or heart attack increase a person’s chances of having a stroke. The aims of this study: Evaluate the role of
electroencephalography and visual evoked potential in patients presented with stroke. Determine the electroencephalographic abnormalities in stroke patients. Evaluate the clinical manifestations and medical history of patient with stroke. This study is a case-control study dealing with a total of 170(male and female) subjects, 85 of them as group presented with stroke and the other 85 considered asa control group. The electrophysiological tests were done at the neurophysiology unit of Mirjan Teaching center in Babylon City, during the period from 1ᵗʰ/12/ 2015 until 20ᵗʰ /5/2016.Electroencephalography and Visual evoked potential were performed for the patients and the control in parallel.This study shows the differences between patients with stroke and control by EEG changes there were significant differences between patients and control by EEG changes. There were 35% of stroke patient presented with abnormal EEG changes ,While 26%of stroke patient presented with abnormal VEP. The purpose of the study was to compare sensitivity and specificity of these two analytical procedures (EEG and VEP) in the diagnosis of stroke. The sensitivity and the specificity of EEG in stroke The results showed a sensitivity of35.3% and a specificity of 97.6%.p value less than 0.01 is highly significant.The sensitivity and the specificity of VEP in stroke The results showed a sensitivity of 25.9% and a specificity of 100% p value less than 0.01 is highly significant.The EEG abnormal findings in stroke patients were (35%) of all patient group (68%) of them were generalized while (32% )were partial seizure.The distribution of different EEG abnormalities in stroke patients were (slow wave 48%,spike wave26%,poly spike wave13% and sharp wave13%).The VEP abnormal findings in stroke patients were(26%) of allpatient group, the majority of abnormal VEP findings were prolonged latency of P100, P75 and P145 respectively.There were significant differences between stroke patients and control group regarding the clinical manifestations and medical history (DM, Headache, Dysarthria , Visual disorder,Facial weakness, dizziness hypertension and Hemiphgia.
Excessive daytime sleepiness and obstructive sleep apnea among aircrew: A questionnaire survey
Authors: Murthy HMK , Mohapatra SS
Published: November 2019

Background:

Obstructive sleep apnea (OSA) is a condition resulting in disrupted sleep and excessive daytime sleepiness/somnolence (EDS) with demonstrable deficits in cognitive and psychomotor performance. Indian studies have shown the prevalence of 4.9–19.7% in males and 2.1–7.4% in females. Prevalence among military aviators is unknown.

Materials and Methods:

EDS was determined by employing Epworth Sleepiness Scale (ESS) among the 54 male aircrews in an airbase. The risk for OSA was also determined among these individuals using STOP-BANG questionnaire.

Results and Discussion:

It was found that none of the aircrews in the study group is found to have dangerously sleepy (DS). About 11.11% of the studied population were found to have EDS which is less than the prevalence rate in India as per a study conducted by the National Institute of Mental Health and Neuro Sciences on general population and the Western world (prevalence rate of 16.7%) as found by Gislason et al. OSA risk among the study population was (n = 9/54) 16.16%. The prevalence of OSA in India male is reported as 4.9–17.9%. Thus, percentage of aircrew showing the risk for OSA in this cross-sectional study is comparable with the general population in India. However, no correlation was found between the risk factors of OSA with ESS. The reasons for EDS could be attributed to factors such as personal lifestyle, sleeping habits, and poor work-rest schedules. It is interesting to note that none of the aircrew, who is positive for OSA risk, is showing EDS/DS. This further confirms that OSA risk individuals may not have EDS/DS and this could be a reason why, OSA largely remains underdiagnosed and untreated in clinical practice.

Conclusion:

This cross-sectional study has brought the conclusion that both EDS and risk for OSA coexists even in a fit and healthy population of aircrew.
Physiological interpretation of almost loss of consciousness
Authors: Khatua SS , Dahiya M , Gowda A , Sannigrahi P
Published: November 2019

Background:

The phenomenon of almost loss of consciousness (A-LOC) is although known to the aviation fraternity since the 1980s, it is not well researched. Very few studies have attempted to elaborate the characteristics of A-LOC. The present study is a retrospective analysis which has endeavored to address the lacunae in literature.

Materials and Methods:

A retrospective analysis of the G training data in high-performance human centrifuge for a time span of 4 years (2009–2013) was carried out.

Results:

A total of 71 A-LOC incidents were reported and were analyzed for better understanding of A-LOC. On the basis of findings such as nystagmus, maintenance of postural tone, convulsions, amnesia, and dreams during A-LOC, neurophysiology of A-LOC has been hypothesized.

Conclusion:

The presence of nystagmus and maintenance of body posture suggest intact vestibulo-ocular reflex and sensory-motor tract, respectively. Non-recollection of dreams, amnesia suggests breach in memory and/ or information processing for higher functions. The mechanism of A-LOC in toto can be explained by regional differences in blood flow and vulnerability of cerebral centers to ischemic hypoxia. Convulsions in A-LOC could be attributed to hyperexcitability of nerve fibers due to hypoxia.
Understanding the Influence of Manufacturing and Material Parameters on the Mechanical Properties of Polymer-Clay Composites: An Exploratory Statistical Analysis
Authors: Botha Natasha , Coetzer Roelof , inglis helen , labuschagne johan
Published: November 2019

This paper analyses a set of previously obtained experimental results on various clay fillers added to high density polyethylene (HDPE). The composite material was compounded using an extrusion process and manufactured into tensile test samples by means of hot pressing. Various manufacturing parameters (number of extrusions, press time, sample cooling method), material (polymer grade, clay type, clay weight loading) and testing parameters (strain rate) were investigated to determine their influence on the mechanical properties of the composite system.

Exploratory data analysis was first employed by graphically representing the data using scatter plots to identify any main characteristics, patterns or anomalies. The statistical analysis was used to quantify the effects of the ultimate tensile strength by first conducting a one way ANOVA analysis before developing a linear model for the response variable analysis. For the percentage elongation to failure, the observations was first grouped into three groups, Brittle, Intermediate or Ductile. A linear discriminant analysis was performed to classify the groups considering a training set of 80% randomly selected observations and testing on the remaining 20%.
A Molecular Computing Approach to Solving Optimization Problems via Programmable Microdroplet Arrays
Authors: Guo Si Yue , Friederich Pascal , Cao Yudong , Wu Tony , Forman Christopher , Mendoza Douglas , Degroote Matthias , Cavell Andrew , Krasecki Veronica , Hickman Riley , Sharma Abhishek , Cronin Leroy , Gianneschi Nathan , Goldsmith Randall , Aspuru-Guzik Alan
Published: November 2019

The search for novel forms of computing that show advantages as alternatives to the dominant von-Neuman model-based computing is important as it will enable different classes of problems to be solved. By using droplets and room-temperature processes, molecular computing is a promising research direction with potential biocompatibility and cost advantages. In this work, we present a new approach for computation using a network of chemical reactions taking place within an array of spatially localized droplets whose contents represent bits of information. Combinatorial optimization problems are mapped to an Ising Hamiltonian and encoded in the form of intra- and inter- droplet interactions. The problem is solved by initiating the chemical reactions within the droplets and allowing the system to reach a steady-state; in effect, we are annealing the effective spin system to its ground state. We propose two implementations of the idea, which we ordered in terms of increasing complexity. First, we introduce a hybrid classical-molecular computer where droplet properties are measured and fed into a classical computer. Based on the given optimization problem, the classical computer then directs further reactions via optical or electrochemical inputs. A simulated model of the hybrid classical-molecular computer is used to solve boolean satisfiability and a lattice protein model. Second, we propose architectures for purely molecular computers that rely on pre-programmed nearest-neighbour inter-droplet communication via energy or mass transfer.
Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease
Authors: Renga Giorgia , Oikonomou Vasilis , Moretti Silvia , Stincardini Claudia , Bellet Marina M , Pariano Marilena , Bartoli Andrea , Brancorsini Stefano , Mosci Paolo , Finocchi Andrea , Rossi Paolo , Costantini Claudio , Garaci Enrico , Goldstein Allan L , Romani Luigina
Published: November 2019

Chronic granulomatous disease (CGD) is a genetic disorder of the NADPH oxidase characterized by increased susceptibility to infections and hyperinflammation associated with defective autophagy and increased inflammasome activation. Herein, we demonstrate that thymosin β4 (Tβ4), a g-actin sequestering peptide with multiple and diverse intracellular and extracellular activities affecting inflammation, wound healing, fibrosis, and tissue regeneration, promoted in human and murine cells noncanonical autophagy, a form of autophagy associated with phagocytosis and limited inflammation via the death-associated protein kinase 1. We further show that the hypoxia inducible factor-1 (HIF-1)α was underexpressed in CGD but normalized by Tβ4 to promote autophagy and up-regulate genes involved in mucosal barrier protection. Accordingly, inflammation and granuloma formation were impaired and survival increased in CGD mice with colitis or aspergillosis upon Tβ4 treatment or HIF-1α stabilization. Thus, the promotion of endogenous pathways of inflammation resolution through HIF-1α stabilization is druggable in CGD by Tβ4.
浅析公路桥梁路面施工技术的应用
Authors: 孔 峰
Published: November 2019

随着中国社会经济的不断发展，对交通运输基础设施建设的需求越来越多，公路桥梁路面建设工程项目获得了迅猛的发展。作为中国交通运输体系的重要组成部分，公路桥梁建设水平和建设质量直接关系着运输行业的稳定发展，但从实际公路桥梁路面施工情况来看，仍然存在各种各样的问题影响工程项目的顺利开展。因此，必须要加强对公路桥梁路面质量的控制，提高公路桥梁路面施工技术应用效率，使得公路桥梁能够长期稳定的运行，促进中国基础设施建设行业的可持续发展。
浅谈建筑电气设计中消防配电设计常见问题的分析
Authors: 李 超
Published: November 2019

目前设计者应该熟悉和掌握的与建筑消防电气有关的设计规范主要有《建筑设计防火规范》GB 50016-2014、《火灾自动报警系统设计规范》 GB50116-2013、《民用建筑电气设计规范》JGJ16-2008 等。前两部是中国国家标准，后者是中国国家建设部发布的行业标准。三部规范对高层建筑中建筑类别的划分以及对火警与消防联动系统的设置及要求是贯彻的，三部不同规范对各自范畴也各有区别及侧重。
建筑结构加固工程的施工质量与安全管理工作剖析
Authors: 龙 涛
Published: November 2019

建筑工程中，结构加固处理是对承载力欠缺、受到破坏的结构实施加固处理的手段，在建筑施工的实际情况中，要对原有建筑结构实施大量的操作，建筑结构的加固施工存在一些安全问题，提高建筑加固施工质量和施工安全性，能够有效降低施工风险，促进相应资源的应用，为建筑结构加固施工的安全营造一个良好的条件。建筑结构加固施工的工程质量和安全管理是必然选择，分析建筑结构加固工程中质量和安全管理的解决对策，能够提高建筑加固的水平，保证建筑的安全性。
铜铝复合材料特性及其制备方法研究
Authors: 周 弦
Published: November 2019

铜铝复合材料是利用了各种复合技术在铜界面与铝界面处实现冶金结合的一种新型材料。铜铝复合材料既具有铜的优点：导电性、导热性良好、易焊接、接触电阻低、易电镀以及外观美观等。同时也具有铝的廉价、质轻、散热性能优良、经济等特点。本文对其复合方法的制备与界面特性进行了一定的研究。
水利工程施工监理中的问题及对策探讨
Authors: 井 涌泉
Published: November 2019

随着中国经济的迅速发展及人民生活质量水平的提升，对于水利工程的质量要求也越来越高。施工监理工作作为水利工程的重要组成部分，对于该工程的质量保障和施工进度方面有着较大的推动作用，所以说，我们要重视对水利工程在施工过程当中的监理工作的建设。
高低压开关柜制造工艺分析
Authors: 昌 家弟
Published: November 2019

随着国家基础设施建设和电力能源投入的发展，中国高低压开关柜需求量逐年增加，产品升级换代速度加快，型号增多，技术性能有了明显的提高。生产设备及加工工艺有了明显改进，在制造高低压开关柜的过程中，不同用户有不同的需求，对高低压开关柜的使用成效也有不一样的要求。因此，在制造高低压开关柜的过程中，需要设计人员针对不同用户的使用需求设计高低压开关柜的结构，并根据需要进行不同程度的调整，从而更好地满足不同用户针对高低压开关柜的不同需求。
试论中国黑臭水体治理及修复技术
Authors: 张 媛
Published: November 2019

目前，黑臭水体已成为拉低生态水平、影响人体健康的一大杀手。对于黑臭水体，需在详细掌握其来源、成因的基础上，根据水体受污染程度采取相应的治理与修复技术，尽快降低水体内污染物指标，提高水体质量。本文联系实际，在简要分析黑臭水体产生原因的基础上，就中国黑臭水体治理及修复技术展开重点探究，以供参考。
预制装配式混凝土结构在高层住宅中的应用
Authors: 李 广惠
Published: November 2019

目前随着中国经济在不断的发展，推动了建筑行业的不断进步，各种先进的科学技术也逐渐被应用于各行各业的发展。由于现代房屋建设技术也在不断提高，而且越来越多的高层建筑在建设过程当中对预制装配式混凝土结构的应用也变得越来越频繁，因此，在此篇文章当中主要分析一下预制装配式混凝土结构在高层住宅当中的应用。
研究国土空间规划体系中的生态环境保护规划
Authors: 朱 阳
Published: November 2019

国土空间规划具有重要的意义，其给国家发展规划明确的重大战略任务落地开展提供空间方面的基础，也给其他规划提出的各种开发保护活动奠定了空间载体基础。所以，现阶段就需要制定生态环境保护专项规划，能够给国土规划体系的有效开展奠定良好的基础，基于此，本文就分析了国土空间规划体系中的生态环境保护规划。
Competency of Islamic Education Teacher to Improve Student Learning Achievement
Authors: Mohammad Rasikhul Islam
Published: November 2019

The competency of the teacher can contribute or increase learning achievement can be an active example of inofative criminative and have high integration in school. The purpose of this research is to know the role of the PAI master competence in enhancing student learning achievement.  This research uses the method of decriptif with a qualitative approach, data collection techniques using observations, interviews and documentation studies. Research subjects are the principals and teachers of PAI. The results of the study showed: (1). Pedagogic competence, (2). Personality Competencies (3). Social competence and (4). Professional competence.
Analisis Maqashid Syari’ah Jasser Auda Terhadap Izin Perkawinan dan Perceraian Bagi Pegawai Negeri Sipil
Authors: Rahman Fawait Syaiful
Published: November 2019

Abstract: Marriage under the provisions contained in the classical books of men who wish to have more than one wife, there is no requirement as regulated in the provisions of Government Regulation No. 45 of 1990 amendment to Government Regulation No. 10 of 1982 concerning Marriage and Divorce Permits Civil Servants, five sufficient conditions for the prospective wife, prospective husband, guardian, two witnesses, and sighat. While civil servants in the PP Article 4 Paragraph 1 men who want to have polygamy should seek permission from their superiors and Religious Courts. According to the researcher need to do re-analysis with appropriate methodology and precisely because the Government Regulation concerning state law order, in order to find whether Government Regulation Number 45 Year 1990 concerning Permit of Marriage and Divorce of Civil Servant have expediency or vice versa. For that the researcher chose Maqashid al-Shari'ah Jasser Auda as a knife of analysis in this study.

This study aims to test empirically the variables that have been formulated in the formulation of the problem, namely reveal the history of birth PP. No. 45 Th. 1990 amendment of PP. No. 10 Th. 1983 on the marriage and divorce of civil servant, the application of the theory of Maqashid al-Shari'ah Jasser Auda to the PP. No. 45 Th. 1990, and analyzed the PP. No. 45 Th. 1990 amendment of PP. No. 10 Th. 1983 on marriage permit and divorce of civil servants with the theory of Maqashid al-Shari'ah Jasser Auda. Research Methods with Approach and Type of Research is a qualitative approach oriented to the statutory approach (Statute Aproach) with the type of research Library (library research). Methods of data collection using documentation, and data analysis using descriptive - inductive.
Tradisi “Berzanjen” Masyarakat Banyuwangi Kajian Resepsi Sastra terhadap Teks al-Barzanji
Authors: Ashari Hasim
Published: November 2019

Abstract: The text of Maulid Al-Barzanji can be considered as an Arabic religious literature. It is a very old text and is still accepted by the society, even in Banyuwangi Society, East Java, the text is very popular. Thus, it obtains a various positive feeds-back from Banyuwangi society. One of the feeds-back is, that it becomes a tradition in the society to read the text when they hold marriage ceremony, a feast for celebrating circumsion, childbirth, and celebration for celebrating the birth of our prophet Muhammad (maulid Nabi). The other feed-back is in the performing art form. Those feeds-back are a manifestation of an Arabi-Islamic cultural transformation process on Banyuwangi society East Java that brings a significant changing in the order of Banyuwangi society culture.
Strategi Kepala Sekolah dalam Meningkatkan Kompetensi Guru Pendidikan Agama Islam di MTs Negeri 6 Banyuwangi
Authors: Ashari Hasim
Published: November 2019

Abstact: The success of an educational institution is very dependent on the leadership of the principal. Because the principal is the leader of his institution, he must be able to bring his institution towards achieving the stated goals, he must be able to see changes and be able to see a better future in the life of globalization. The principal must be responsible for the smoothness and success of all formal arrangements and management affairs for his superiors or informally to the people who have entrusted their students. The Principal must have a strategy in Increasing Teacher Competence.
Membumikan Nilai-nilai Nasionalis-Pancasilais dalam Keluarga sebagai Implementasi Membangun Moderasi Bangsa
Authors: Juwono Hendro
Published: November 2019

Abstract: In the family there are sub-sections starting from father, mother, and child. Togetherness of children with parents before children continue their studies in the context of self-development is enough to determine the attitudes, views, and behavior in the future, because the position of the two parents to children is the first madrasa. Value is an ability that is believed to exist in an object that causes someone and group interest. Whereas according to Dayakisni value is a broad tendency to prefer or choose certain conditions compared to others. So grounding nationalist values ​​is a form of planting values ​​of lovers of the country and the nation, so that with this love someone will automatically search for all information about something he loves in order to protect and defend anyone who tries to disrupt and even undermine the integrity of his nation .