bluuebunny/crossref_metadata_2025 huggingface dataset:
Manipulating Interlayer Excitons for Ultra-pure Quantum Light Generation
Authors: Zhao Huan , Zhu Linghan , Li Xiangzhi , Chandrasekaran Vigneshwaran , Baldwin John , Pettes Michael , Piryatinski Andrei , Yang Li , Htoon Han
Published: April 2022

Interlayer excitons (IXs) formed at the interface of two different atomically-thin semiconductors have been emerging as an exciting ground not only for exploring fascinating many-body phenomena such as exciton condensation,1-4 but also for realizing exciton-based information processing technologies.5, 6 In a parallel development, nanoscale strain engineering has emerged as an effective means for the localization of 2D intra-layer excitons and activation of defect states for quantum light generation.7-11 Exploring the intersection of these two exciting areas, where strain and defects are exploited for the manipulation of IX toward the emergence of new functionalities, is currently at a nascent stage.6 Here, using MoS2/WSe2 heterostructure as a model system, we demonstrate how strain, defects, and layering can be utilized as control knobs toward novel defect-bound IXs capable of bright, robust, and tunable quantum light emission in the technologically important near-infrared spectral range. More significantly, because the deep-level sulfur vacancy states isolate our quantum emitters (QEs) from any of the intra- and inter-layer excitons, we were able to achieve ultra-high single-photon purity with g(2)(0) = 0.01 meeting the critical milestone for quantum key distribution (QKD), logic gate and memory technologies.12 Our strategy of creating site-controlled QEs from the defect-bound IXs represents a paradigm shift in 2D quantum photonics research, from engineering intralayer exciton in monolayer structures towards IXs at the interface of 2D heterostructures.
Room-temperature–low-pressure-operating high-energy lithium metal batteries employing garnet-type solid electrolytes and anode interlayers
Authors: Kim Ju-Sik , Yoon Gabin , Kim Sewon , Sugata Shoichi , Yashiro Nobuyoshi , Suzuki Shinya , Lee Myung-Jin , Kim Ryoung-Hee , Badding Michael , Song Zhen , Chang JaeMyung , Im Dongmin
Published: April 2022

Lithium metal batteries (LMBs) are considered the most promising next-generation battery system because of their high energy density and safety. Significant research effort has been devoted to developing more stable and energy-dense LMBs than the state-of-the-art Li-ion batteries. However, the LMB performance remains unsatisfactory for commercialization, primarily owing to the inability of solid electrolytes to block Li dendrite propagation. Herein, we demonstrate highly stable LMB employing garnet-type oxide electrolyte by introducing a carbon-based interlayer with careful interface engineering. We theoretically and experimentally demonstrate that our design effectively regulated Li deposition away from the solid electrolyte, preventing dendrite penetration. We further demonstrated that the interface condition between the interlayer and solid electrolyte is critical and present an effective strategy to achieve an optimal interface. Overall, our garnet-type oxide-based LMB exhibited a high energy density of ~ 680 Wh/L for over 800 cycles at room temperature without using external pressure.
Preliminary efficacy of [90Y] DOTA-biotin-avidin radiotherapy against non-muscle invasive bladder cancer
Authors: Alì Alessandra , Leibowitz Dev , Bhatt Nikunj , Doubrovin Mikhail , Bates-Pappas Gleneara E. , Taub Robert N. , McKiernan James M , Mintz Akiva , Molotkov Andrei
Published: April 2022

Purpose: Bladder cancer represents 3% of all new cancer diagnoses per year. We propose intravesical radionuclide therapy using the β-emitter 90 Y linked to DOTA-biotin-avidin ([ 90 Y]DBA) to deliver short-range radiation against non-muscle invasive bladder cancer (NMIBC). Material and methods: Image-guided biodistribution of intravesical DBA was investigated in an animal model by radiolabeling DBA with the 68 Ga and dynamic microPET imaging following intravesical infusion of [ 68 Ga]DBA for up to 4 hours and post-necropsy γ-counting of organs. The antitumor activity of [ 90 Y]DBA was investigated using an orthotopic MB49 murine bladder cancer model. Mice were injected with luciferase-expressing MB49 cells and treated via intravesical administration with 9.2 MBq of [ 90 Y]DBA or unlabeled DBA 3 days after the tumor implantation. Bioluminescence imaging was conducted after tumor implantation to monitor the bladder tumor growth. In addition, we investigated the effects of [ 90 Y]DBA radiation on urothelial histology with immunohistochemistry analysis of bladder morphology. Results: Our results demonstrated that DBA is contained in the bladder for up to 4 hours after intravesical infusion. A single dose of [ 90 Y]DBA radiation treatment significantly reduced growth of MB49 bladder carcinoma. Attaching 90 Y to the DOTA-avidin prevents its re-absorption into the blood and distribution throughout the rest of the body. Furthermore, immunohistochemistry demonstrated that [ 90 Y]DBA radiation treatment did not irreversibly damage the bladder urothelium, which appeared similar to the normal urothelium of healthy mice. Conclusion: Our data demonstrates the potential of intravesical [ 90 Y]DBA as a treatment for non-muscle invasive bladder cancer.
Fabricating the canola oil Nanoemulsion and assessing its anti-cancer effects on the mouse mammary gland tumor
Authors: neamati ali , Yousefi Yeganeh , Homayouni-Tabrizi Masoud , Pournaghshband Negar
Published: April 2022

The aim of this study was twofold, a) to synthesize a Nanoemulsion from canola oil (CO-NE) and b) to investigate its antitumor effects. Ultrasonic method and Tween 20 and 80 with ethylene glycol were used to synthesize canola oil Nanoemulsion. Tissue changes of mice model were also assessed. The results showed that the CO-NE with a size of 40.94 nm, a zeta potential of -29.67 mV, and a dispersion index of 0.21 has a selective toxicity effect on mouse breast cancer cells.
Giant Enhancement of Second-Harmonic Generation in Hybrid Metasurface Coupled MoS2 with Fano-Resonance effect
Authors: Xie Yunfei , Yang Liuli , Du Juan , Li Ziwei
Published: April 2022

Plasmonic nanostructures have been regarded as potential candidates for boosting the nonlinear up-conversion rate at nanoscale level due to their strong near-field enhancement and inherent high design freedom. Here, we design a hybrid metasurface to realize the moderate interaction of Fano resonance and create the dual-resonant mode-matching condition to facilitate nonlinear process of second harmonic generation (SHG). The hybrid metasurface presents dipolar and octupolar plasmonic modes near the fundamental and doubled-frequency wavelengths, respectively, which is further utilized to enhance the SHG of low-dimensional MoS2 semiconductor. The maximum intensity of SHG in hybrid metasurface coupled MoS2 is more than ten thousand times larger than that of other structure-units coupled MoS2, and the conversion efficiency is reported to be as high as 3.27×10−7. This work paves the way for optimizing nonlinear light-matter interactions in low-dimensional structures coupled semiconductors.
Necroptosis-Related microRNA (mir-331-3p) is Expected to Become a New Target for the Treatment of Cervical Cancer
Authors: Wang Hui , Huang Lisheng , Li Guang
Published: April 2022

Background: There are no studies on the relationship between the expression of necroptosis-related miRNAs and the prognosis of cervical cancer. We aimed to use The Cancer Genome Atlas (TCGA) database to mine necroptosis-related microRNAs (miRNAs). Cervical cancer-related data in the TCGA database were downloaded and necroptosis-related miRNAs were collected. First, differential analysis of necroptosis-related miRNAs was carried out, and the differentially expressed miRNAs were constructed and analyzed by univariate and multivariate Cox regressions. miRNAs with significant differences were screened and the prognoses of the obtained miRNAs was analyzed. Finally, the downstream target genes and downstream target gene enrichment pathways of prognosis-related miRNAs were determined, and the possible role of miRNAs in cervical cancer was explored. Results: Six differentially expressed miRNAs were identified by differential analysis and survival analysis of the obtained differential genes showed that the expression level of mir-331-3p was positively correlated with patient prognosis. Finally, the pathway enrichment analysis of the mir-331-3p downstream target gene showed that it was significantly enriched in positive regulation of gene expression, mRNA catabolic process, regulation of G2/M transition of mitotic cell cycle, regulation of cell cycle G2/M phase transition, activation of innate immune response as well as DNA-binding transcription repressor activity. Conclusion: In cervical cancer, necroptosis-related miRNAs (mir-331-3p) can accelerate the death of cervical cancer cells by activating body immunity, promoting RNA decomposition, regulating G2/M conversion, and has an antitumor effect. It is expected to become a new target in the treatment of cervical cancer.
Effects of mating status on cold tolerance in small hive beetle, Aethina tumida
Authors: Noor-ul-Ane Muhammad , Jung Chuleui
Published: April 2022

The small hive beetle (SHB) Aethina tumida Murray, (Coleoptera: Nitidulidae) has become a global pest of honey bees, but to date its adults’ cold tolerance has not been explored. Mating increases the cold tolerance in some insects. Therefore, we appraised the effect of mating on overwintering traits; Supercooling points (SCPs) and, lower lethal temperatures. We also assayed the phenotypic plasticity of SHB adults and subsequent reproductive capacity of SHB females. The supercooling points occurred at lower temperatures (-10.8℃) in mated females than in the other tested adults (mated males: -9.1℃, unmated males: -8.5℃, and unmated females: -8.0℃). The sum of injurious temperature (SIT) was the utmost expedient estimation to characterize that mated females were the most cold-resilient (-119.8 DD). Acclimation mitigated the detrimental effects of lethal temperatures and increased egg laying compared with their counterpart control. However, this phenotypic plasticity of SHB females reduced egg laying of mated and unmated females (23.7, 25.0 eggs/female, respectively) by comparison to laboratory reared untreated females (31.4 eggs/female). Our results revealed that SHB adults are chill-susceptible regardless of their mating status but have the ability to show phenotypic plasticity. Females irrespective of their mating status, paid the reproductive cost for this plasticity. The mating neither provides any advantage to SHB females to survive cold temperatures nor the subsequent reproductive output. However, mating does reduce the cold tolerance in SHB males. This study predicts that phenotypic plasticity still could be supplementing the expansion of SHB to higher latitude areas, markedly in the scenario of climate change.
X Chromosome Associations with Chronic Obstructive Pulmonary Disease and Related Phenotypes: An X Chromosome-wide Association Study
Authors: Hayden Lystra P , Hobbs Brian D , Busch Robert , Cho Michael H , Liu Ming , Lopes-Ramos Camila M , Lomas David A , Bakke Per , Gulsvik Amund , Silverman Edwin K , Crapo James D , Beaty Terri H , Laird Nan M , Lange Christoph , DeMeo Dawn L
Published: April 2022

BACKGROUND: The association between genetic variants on the X chromosome to risk of COPD has not been fully explored. We hypothesize that the X chromosome harbors variants important in determining risk of COPD related phenotypes and may drive sex differences in COPD manifestations.METHODS: Using X chromosome data from three COPD-enriched cohorts of adult smokers, we performed X chromosome specific quality control, imputation, and testing for association with COPD case-control status, lung function, and quantitative emphysema. Analyses were performed among all subjects, then stratified by sex, and subsequently combined in meta-analyses. RESULTS: Among 10,193 subjects of non-Hispanic white or European ancestry, a variant near TMSB4X, rs5979771, reached genome-wide significance for association with lung function measured by FEV1/FVC ( 0.020, SE 0.004, p 4.97x10-08), with suggestive evidence of association with FEV1 ( 0.092, SE 0.018, p 3.40x10-07). Sex-stratified analyses revealed X chromosome variants that were differentially trending in one sex, with significantly different effect sizes or directions.CONCLUSIONS: This investigation identified loci influencing lung function, COPD, and emphysema in a comprehensive genetic association meta-analysis of X chromosome genetic markers from multiple COPD-related datasets. Sex differences play an important role in the pathobiology of complex lung disease, including X chromosome variants that demonstrate differential effects by sex and variants that may be relevant through escape from X chromosome inactivation, as seen with TMSB4X. Comprehensive interrogation of the X chromosome to better understand genetic control of COPD and lung function is important to further understanding of disease pathology.Trial registration: Genetic Epidemiology of COPD Study (COPDGene) is registered at ClinicalTrials.gov, NCT00608764 (Active since January 28, 2008). Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study (ECLIPSE), GlaxoSmithKline study code SCO104960, is registered at ClinicalTrials.gov, NCT00292552 (Active since February 16, 2006). Genetics of COPD in Norway Study (GenKOLS) holds GlaxoSmithKline study code RES11080, Genetics of Chronic Obstructive Lung Disease.
The Geoheritage in the North of Tocantins State and Southwest of Maranhão State
Authors: Lopes Raylon , Lima Claudia Valéria , Candeiro Carlos Roberto
Published: April 2022

The Brazilian territory has a significant and diversified geoheritage, but there is still a lack of knowledge about it, especially in areas far from metropolitan regions, where most of the research is concentrated. In this work, elements of great significance of the geodiversity in the north of the state of Tocantins and southwest of Maranhão are approached. The region is located on the Brazilian agricultural frontier, a fact that makes it important to know its physical-natural diversity and to provide an overview of the importance that some portions of the area have for conservation and sustainable development. In the region, there are significant sites composed of fossils, waterfalls and geoforms that, according to a theoretical review of the themes addressed and the field work, are important for carrying out scientific, didactic and geotouristic activities.
Cortical Grey Matter Volume Loss links to Neurological Sequelae in post COVID-19 “Long Haulers”
Authors: Rothstein Ted L.
Published: April 2022

Objective
COVID-19 (SARS-CoV-2) has been associated with neurological sequelae even in those patients with mild respiratory symptoms. Patients experiencing cognitive symptoms such as “brain fog” and other neurologic sequelae for more than 4 weeks define “long haulers”. There is limited information regarding damage to grey matter structures occurring in COVID-19 “long haulers”. Detecting possible anatomic changes related to COVID-19 is important as conventional Brain MRI often fails to identify disease correlates. 3-dimensional voxel-based morphometry (3D VBM) accurately analyzes, segments and quantifies brain volumes which allows for comparisons between infected COVID-19 “long haulers” and normative data from age and sex-matched healthy controls to obtain values based on their percentage of intracranial volume.
Methods
This study involved 19 consecutive post COVID-19 surviving “long haulers” who experienced neurologic symptoms. Each patient had Brain MRI with 3D VBM at median time of 72 days following laboratory confirmation. All patients had relatively mild respiratory symptoms which did not require oxygen supplementation, hospitalization, or assisted ventilation. 3D VBM was obtained for whole brain, forebrain parenchyma, cortical grey matter, hippocampus, and thalamus.
Results
The key finding is a statistically significant loss of cortical grey matter (CGM) volume in each COVID-19 “long hauler”. The loss of CGM volume likely contributes to long term neurological sequelae resulting from COVID-19 infection.
Conclusion
This study provides evidence for selective loss of volume in CGM as documented by 3D VBM in 19 COVID-19 “long haulers”. Damage to the CGM provides linkage to neurologic symptoms which can affect their quality of life.
Predicting health outcomes through machine learning in pediatric heart transplantation: Use of national data from the United Network for Organ Sharing
Authors: Killian Michael O. , Tian Shubo , Xing Aiwen , Hughes Dana , Gupta Dipankar , He Zhe
Published: April 2022

Background
Prediction of post-transplant health outcomes for pediatric heart transplantation is critical for high quality post-transplant care. The purpose of the current study is to examine the use of machine learning models to predict late acute rejection, hospitalizations, and mortality for pediatric heart transplant recipients.
Methods
Various traditional machine learning and deep learning models were used to predict late acute rejection, hospitalizations, and mortality at 1-, 3-, and 5-years post-transplant in pediatric heart transplant recipients using the national United Network for Organ Sharing data. Variables predicting post-transplant outcomes included donor and recipient medical and social predictors. SHAP (SHapley Additive exPlanations) were calculated to estimate the importance of each variable for prediction and to increase the interpretability of modeling results.
Results
Logistic regression, random forest, and adaptive boosting models were the best performing algorithms for different prediction windows across outcomes. Based on the area under the receiver operating curve, models predicting rejection and mortality were found to be more accurate than those predicting hospitalizations.
Conclusions
Machine learning approaches can identify unique risk factors, their complex relationship with outcomes using prediction modeling, thereby aiding in identifying at-risk patients, providing a solid foundation for improved clinical care, risk stratification, and guiding decision-making within pediatric organ transplant centers. The current study demonstrates the value of machine learning approaches for modeling post-transplant health outcomes using patient-level data and informs the transplant community about the future potential of these innovative approaches to improve pediatric post-heart transplant care.
A simple hybrid statistical-dynamical downscaling method for emulating regional climate models over Western Europe. Evaluation, application, and role of added value?
Authors: Boé Julien , Mass Alexandre
Published: April 2022

A hybrid statistical dynamical downscaling method intended to emulate regional climate models is described and applied on Western Europe. The method is based on a constructed analogues algorithm, already used for statistical downscaling. For emulation, the statistical downscaling relationship is not derived from observations but from climate projections at low and high resolution. The hybrid approach therefore does not rely on the stationarity assumption inherent to conventional statistical downscaling.Within a perfect model framework, and using a large number of regional projections, the hybrid method is shown to very well reproduce climate change signals, and to clearly outperforms conventional statistical downscaling. The hybrid approach remains skillful even when applied to very low-resolution climate data. In practice, two emulation modes exist. In the GCM / RCM mode, the downscaling relationship is built between a RCM and its forcing GCM. In the RCM / RCM mode, the relationship is built between a RCM and the same RCM after aggregation of its results to a low resolution grid. The large-scale climate change signal of the downscaled GCM is generally retained with the RCM / RCM mode, but not with the GCM /RCM mode. Additionally, the choice of the GCM / RCM pair used for learning leads to large differences in downscaling results at large scale with the GCM /RCM mode, but not with the RCM / RCM mode. These results are explained by the differences that exist at large scale between projected changes by current RCMs and their forcing GCMs. Whether these differences are a testimony of a real added value of RCMs at large scale in the climate change context, or whether they have other causes, is therefore a crucial question.
Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway
Authors: Li Rong , Guo Yujie , Zhang Huiqing , Lv Zhe , Du Yuna , Li Dan , Fang Hui , You Jing , Yu Lijun
Published: April 2022

Background: Sepsis is a life-threatening organ dysfunction syndrome resulted from severe infection with high morbidity and mortality. Cluster of differentiation 38 (CD38) is a multifunctional type Ⅱ transmembrane glycoprotein widely expressed on the surface of various immunocytes membranes that mediates host immune response to infection and plays an important role in many inflammatory diseases. Daphnetin (Daph), isolated from the daphne genus plant, is a natural coumarin derivative that possesses anti-inflammatory and anti-apoptotic effects. The current study aimed to investigate the role and mechanism of Daph in alleviating lipopolysaccharide (LPS)-induced septic lung injury, and to explore whether the protective effect of Daph in mice and cell models was related to CD38. Methods: Firstly, Network pharmacology analysis of Daph was performed. Secondly, LPS-induced septic lung injury in mice were treated with Daph or vehicle control respectively and then assessed for survival, pulmonary inflammation and pathological changes. Lastly, Mouse lung epithelial cells (MLE-12 cells) were transfected with CD38 overexpressed plasmid, followed by LPS and Daph treatment. Cells were assessed for viability and transfection efficiency, inflammatory and signaling.Results: Our results indicated that Daph treatment improved survival rate and alleviated pulmonary pathological damage of the sepsis mice, as well as reduced the excessive release of pro-inflammatory cytokines IL-1β, IL-18, IL-6, iNOS and chemokines MCP-1 regulated by MAPK/NF-κB pathway in pulmonary injury. Daph treatment decreased Caspase 3 and Bax, increased Bcl-2, inhibited nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome‐mediated pyroptosis in lung tissues of septic lung injury. Also, Daph treatment reduced the level of excessive inflammatory mediators, inhibited apoptosis and pyroptosis in MLE-12 cells. It is noteworthy that the protective effect of Daph on MLE-12 cells damage and death was assisted by the enhanced expression of CD38. Conclusions: Our results demonstrated that Daph offered a beneficial therapeutic effect for septic lung injury via the up-regulation of CD38 and inhibition of MAPK/NF-κB/NLRP3 pathway.
Cost Optimization in Cloud Environment based on Task Deadline
Authors: Ahmad Saima Gulzar , Munir Ehsan Ullah , Ramzan Naeem
Published: April 2022

The task of a service broker in a cloud computing environment is vital and challenging. Several sophisticated techniques have been proposed to improve the overall performance and minimize the cost. Most of the approaches optimize either performance or the cost; however, the users of cloud and fog need the best compromise for both. In this paper, we propose a hybrid technique that is Cost Optimization in the cloud/fog environment based on Task Deadline (COTD) that focuses on both parameters simultaneously and maintains the Quality of Service. The proposed algorithm is based on the task deadline and selects the most appropriate data center for task processing. We have implemented and tested COTD on a well-known simulation tool Cloud Analyst. Our comprehensive testbed experiments and simulations show that COTD outperforms comparable with Service Proximity Based Routing and Performance-Optimized Routing, and successfully minimizes an average of 35% cost while maintaining the same response time.
Blockage of MDM2-mediated p53 ubiquitination by yuanhuacine restrains the carcinogenesis of prostate carcinoma cells by suppressing LncRNA LINC00665
Authors: Yan Miao , Li Xin , Gu Jinbao , Gao Guojun , Wu Ziyu , Xue Peng
Published: April 2022

Prostate cancer (PCa) is known as a challenging issue for the global men health due to its uncontrolled proliferation and high metastatic potential. Increasing evidence has supported plant extracts and plant-derived natural derivatives as a promising anti-tumor therapeutics as their less toxic side effects. Yuanhuacine is an active component isolated from Daphne genkwa and can effectively suppress tumorigenesis of several cancers. However, its role in PCa is still unclear. In this study, yuanhuacine dose-dependently inhibited PCa cell proliferation and induced cell apoptosis. Moreover, yuanhuacine treatment also restrained PCa cell invasion and migration. Mechanically, yuanhuacine decreased p53 protein ubiquitination, degradation and ultimately increased p53 levels, which was regulated by inhibiting phosphorylation and total protein levels of Mouse Double Minute 2 (MDM2). Moreover, elevation of MDM2 reversed the suppressive efficacy of yuanhuacine in PCa cell viability, invasion and migration. The network pharmacology and bioinformatics analysis confirmed that MDM2 might be a common target of Daphne genkwa and LINC00665. Furthermore, yuanhuacine reduced LINC00665 expression. Up-regulation of LINC00665 inversed yuanhuacine-mediated inhibition in MDM2 protein expression and suppressed p53 levels by enhancing its ubiquitination in yuanhuacine-treated cells. Importantly, the inhibitory effects of yuanhuacine on cell viability and metastatic potential were offset after LINC00665 elevation. Together, the current finding highlight that yuanhuacine may possess its tumor-suppressive efficacy by inhibiting LINC00665-mediated MDM2/p53 ubiquitination signaling. Therefore, this data indicate that yuanhuacine may be a promising candidate for the treatment of PCa.
Reactogenicity, Safety, and Serological and Cellular Immunogenicity of a Booster Dose of SARS-CoV-2 mRNA Prototype, Variant, and Bivalent Vaccines
Authors: Anderson Evan J. , Jackson Lisa A. , Rouphael Nadine G. , Widge Alicia T. , Montefiori David , Doria-Rose Nicole A. , Suthar Mehul , Cohen Kristen W. , O’Connell Sarah , Makowski Mat , Makhene Mamodikoe , Buchanan Wendy , Spearman Paul , Creech C. Buddy , O’Dell Sijy , Schmidt Stephen D , Leav Brett , Bennett Hamilton , Pajon Rolando , Posavad Christine M. , Hural John , Beigel John H. , Albert Jim , Abebe Kuleni , Eaton Amanda , Rostad Christina A. , Rebolledo Paulina A. , Kamidani Satoshi , Graciaa Daniel S. , Coler Rhea , McDermott Adrian , Ledgerwood Julie E. , Mascola John R. , De Rosa Stephen C. , Neuzil Kathleen M. , McElrath M. Juliana , Roberts Paul C.
Published: April 2022

Waning immunity after two SARS-CoV-2 mRNA vaccinations and the emergence of variants precipitated the need for booster doses. We evaluated safety and serological and cellular immunogenicity through 6 months after a third mRNA vaccination in adults who received the mRNA-1273 primary series in the Phase 1 trial approximately 9 to 10 months earlier. The booster vaccine formulations included 100 mcg of mRNA-1273, 50 mcg of mRNA-1273.351 that encodes Beta variant spike protein, and bivalent vaccine of 25 mcg each of mRNA-1273 and mRNA-1273.351. A third dose of mRNA vaccine appeared safe with acceptable reactogenicity. Vaccination induced rapid increases in binding and neutralizing antibody titers to D614G, Beta, Delta and Omicron variants that persisted through 6 months post-boost, particularly after administration of Beta-containing vaccines. Spike-specific CD4 + and CD8 + T cells increased to levels similar to those following the second dose. Boost vaccination induced broad and durable humoral and T cell responses. ClinicalTrials.gov numbers NCT04283461 (mRNA-1273 Phase 1) and NCT04785144 (mRNA-1273.351 Phase 1)
The magnitude of combined training-induced changes in executive functions is related to pre-training BDNF levels in middle-aged and older adults with Type 2 Diabetes Mellitus
Authors: Silveira-Rodrigues João Gabriel da , Nogueira Nathálya Gardênia de Holanda Marinho , Faria Larissa Oliveira , Pereira Daniele Sirineu , Soares Danusa Dias
Published: April 2022

Background: Many cognitive functions are affected by Type 2 Diabetes Mellitus (T2DM). Aerobic plus resistance exercise training, known as combined training (CT), may mitigate or reverse the T2DM-related cognitive impairment by improving metabolic control. Brain-derived neurotrophic factor (BDNF) seems to modulate the cognitive functions of healthy and T2DM adults. However, the CT-effects on BDNF levels of T2DM subjects need to be better elucidated. Aim: To analyze the effects of 8-week CT on circulating BDNF levels of T2DM subjects. Additionally, were investigated the relationship between BDNF levels and CT-induced changes in executive functions and long-term memory of T2DM subjects. Methods: Thirty-five (63 ± 8 years old) T2DM subjects of both sexes were allocated to CT (n=17, thrice-weekly during 8 weeks) or control group (CONT, n=18). Executive functions (evaluated through Trail making test, Stroop color task, and Digit Span), long-term memory (evaluated through the simplified version of Taylor Complex Figure Test), and plasma samples were analyzed pre- and post-intervention. Results: CT induced higher improvements in executive functions composite z-score than CONT (d= 1.31). BDNF levels were not statistically altered (pre-CT: 179±88 pg/ml; post-CT: 148±108 pg/ml; pre-CONT: 163±71 pg/ml; post-CONT: 141±84 pg/ml, p> 0.05). However, pre-CT BDNF levels were positively related to CT-induced changes on executive functions composite z-score (r= 0.71), inhibitory control (r= 0.58) and cognitive flexibility (r= 0.56). Conclusion: CT improved executive functions and higher pre-training BDNF levels have been correlated to those CT-induced improvements on executive functions, independently of the training alterations in resting BDNF levels of T2DM subjects.
Leather-Like Material Based on Natural Rubber Composites
Authors:   Division of Physical Science, Faculty of Science, Prince of Songkla University, No.15, Karnjanavanich Rd., Hat Yai, Songkhla 90110, Thailand, Sourprae Karn , Kalkornsurapranee Ekwipoo ,   Division of Physical Science, Faculty of Science, Prince of Songkla University, No.15, Karnjanavanich Rd., Hat Yai, Songkhla 90110, Thailand, Lehman Nussana ,   Division of Physical Science, Faculty of Science, Prince of Songkla University, No.15, Karnjanavanich Rd., Hat Yai, Songkhla 90110, Thailand, Chuaybamrung Arthittaya ,   Division of Physical Science, Faculty of Science, Prince of Songkla University, No.15, Karnjanavanich Rd., Hat Yai, Songkhla 90110, Thailand, Tuljittraporn Akarapong ,   Division of Physical Science, Faculty of Science, Prince of Songkla University, No.15, Karnjanavanich Rd., Hat Yai, Songkhla 90110, Thailand, Nakaramontri Yeampon ,   Polymer & Innovative Composite Materials Research Group, Department of Chemistry, Faculty of Science, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand 10140, Krainoi Apinya ,   Polymer & Innovative Composite Materials Research Group, Department of Chemistry, Faculty of Science, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand 10140, Johns Jobish ,   Department of Physics, Rajarajeswari College of Engineering, No.14, Kumbalgodu, Mysore Road, Bengaluru 560 074, Karnataka, India, Songtipya Ladawan ,   Department of Material Product Technology, Faculty of Agro-Industry, Prince of Songkla University, No.15, Karnjanavanich Rd., Hat Yai, Songkhla 90110, Thailand, Uthaipan Nattapon ,   Rubber Engineering and Technology Program, International College, Prince of Songkla University, No.15, Karnjanavanich Rd., Hat Yai, Songkhla 90110, Thailand
Published: April 2022

This research was conducted to study x-ray and gamma radiation shielding parameters such as mass attenuation coefficient, mean free path, half value layer, tenth value layer, effective atomic numbers, effective electron density for the xBi2O3-(95-x)B2O3-5BaO (where x = 20 mol%, 35 mol%, 50 mol%, and 70 mol%) glass systems with different molar composition. The studied ceramic specimens were denoted by BB20, BB35, BB50 and BB70 and their density values were 4.438 g/cm3, 5.973 g/cm3, 7.156 g/cm3, and 8.005 g/cm3, respectively. Radiation shielding parameters of the samples were investigated by using web based XCOM programme. The obtained results revealed that the highest mass attenuation coefficients were reported for BB70 sample, which has the highest Bi2O3 additive in its chemical structure. At 7 MeV photon energy, half value layer (HVL) values were reported as 5.7812 cm, 3.8065 cm, 2.8533 cm, and 2.2457 cm for BB20, BB35, BB50 and BB70, respectively. Therefore, it can be concluded that the present bismuth sesquioxide based glasses in the Bi2O3-B2O3-BaO glass system have a good quality in radiation protection purposes. Therefore, this glass system can be used as an alternative to conventional materials with the right molar compositon in its chemical formation.
NECROSE DES LIGAMENTS HEPATIQUES: A PROPOS DUNE RARE OBSERVATION
Authors: S. Ouakri , B. Daoudi , A. Chanfir , A. Hamri , Y. Narjis , R. Benelkhaiat
Published: April 2022

La gangrene des ligaments hepatiques (falciforme et/ou rond) est une pathologie exceptionnelle et meconnue et peut presenter un dilemme diagnostique. Nous rapportons le cas dun abces necrose du ligament falciforme avec pylephlebite secondaire a une pyocholecyste. Le tableau clinique etait impressionnant et bruyant. Le diagnostic avait ete evoque sur le scanner, avec la decouverte dune lesion circonscrite de densite graisseuse, pre-hepatique, dans la fissure du ligament rond, a la jonction des segments III et IV du foie. Linteret de lexploration chirurgicale est surtout diagnostique dans la mesure oÃ¹ levolution est toujours favorable, independamment des modalites de lexcision des zones necrotiques. Dans cet article, nous discutons les particularites diagnostiques et therapeutiques de cette entite.
SPONDYLOPTOSE DYSPLASIQUE L5-S1 CHEZ UN ENFANT DE 7 ANS: ETUDE DE CAS ET REVUE DE LA LITTERATURE
Authors:   Service De Radiologie Hopital Mere Et Enfant. Chu Mohammed Vi Marrakech Universite Cadi Ayyad., Zitouni K. , Baadi F. ,   Service De Radiologie Hopital Mere Et Enfant. Chu Mohammed Vi Marrakech Universite Cadi Ayyad., Ouha M. ,   Service De Radiologie Hopital Mere Et Enfant. Chu Mohammed Vi Marrakech Universite Cadi Ayyad., Zouita B. ,   Service De Radiologie Hopital Mere Et Enfant. Chu Mohammed Vi Marrakech Universite Cadi Ayyad., Basraoui D. ,   Service De Radiologie Hopital Mere Et Enfant. Chu Mohammed Vi Marrakech Universite Cadi Ayyad., Jalal H. ,   Service De Radiologie Hopital Mere Et Enfant. Chu Mohammed Vi Marrakech Universite Cadi Ayyad.
Published: April 2022

A 7-year-old girl, a history of cleft palate surgery, presented with primary complaints of severe back pain with radiation to both lower limbs below the knees 2 months following, with inability to stand or walk, of unknown cause history. Her obstetric, developmental, and family history was normal. Inspection of her posture on standing revealed severe sagittal plane deformity including lumbosacral kyphosis and lumbar hyperlordosis with flexion at hips and knees (crouched position). with back pain radiating to the legs, motor and sensory dysfunction of the lower extremities, bladder dysfunction, and saddle anesthesias. Plain radiography and computed tomography (CT scan) showed bilateral L5 pars defect, dysplastic L5- S1 facets, trapezoidal L5 vertebral body, retroverted sacrum with rounding of proximal endplate, and complete anterior descent of the L5 vertebrae to the sacrum (Figures 2(a)â€“2(d)). Magnetic resonance imaging (MRI) of lumbosacral region revealed severe dural compression at L5-S1 level and L5-S1 intervertebral disc degeneration (Figure 3).
WOMEN EMPOWERMENT - A MULTI-DIMENSIONAL STUDY
Authors:   Assistant Professor, Department Of Economics, Dwaraka Doss Goverdhan Doss Vaishnav College, Arumbakkam, Chennai- 106., Sugantha A. , Meenakshi V. ,   Assistant Professor, Department Of Economics, Dwaraka Doss Goverdhan Doss Vaishnav College, Arumbakkam, Chennai- 106., Prema T.S. ,   Associate Professor& Head, PG & Research Department Of Economics, Dwaraka Doss Goverdhan Doss Vaishnav College, Arumbakkam, Chennai- 106.
Published: April 2022

Empowerment is then the process of obtaining these basic opportunities for marginalized people, either directly by those people, or through the help of non-marginalized others who share their own access to these opportunities. Empowerment also includes encouraging, and developing the skills for, self-sufficiency, with a focus on eliminating the future need for charity or welfare in the individuals of the group. This process can be difficult to start and to implement effectively. Empowerment includes control over resources physical, human, intellectual and financial) and over ideology (beliefs, valuesand attitudes) It is not merely a feel of greater extrinsic control, but also grows intrinsic capacity, greater self-confidence and an internal transformation of ones consciousness that enables one to overcome external barriers to accessing resources or changing traditional ideology.
FIBROUS DYSPLASIA OF THE MIDDLE TURBINATE: RARE LOCALIZATION
Authors:   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Moumni M. , Zalagh M. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Ould Cheikh El Wely H. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Oubenjah J. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Ouardi K. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Ftouhi A. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Costa A.H.Da ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Ouraini S. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Hemmaoui B. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Errami N. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo., Benariba F. ,   Otorhinolaryngology and Head & Neck Surgery Department, Mohammed V Military Hospital, Rabat, Morocoo.
Published: April 2022

Fibrous dysplasia is a rare bone pathology and it can often go unnoticed due to its few symptoms.Despite being a benign process, it can behave in aggressively by its local growth, and sometimes degenerate to osteosarcoma. We report a case of fibrous dysplasia which is atypical due to its exclusive location in the middle turbinate.The diagnostic and therapeutic problems that this entails are raised.
LIP REPOSITIONING SURGERY ALONG WITH ESTHETIC CROWN LENGTHENING FOR THE TREATMENT OF GUMMY SMILE:A CASE REPORT
Authors: K.B Uthappa , Golla Sujitha , Walvekar Amit , K. Arun , Hari Amal , S. Menon Gayathry
Published: April 2022

Excessive gingival display is an aesthetic concern that may be addressed with a variety of methods. Lip repositioning is a treatment option for people who are concerned about their appearance. Excessive gingival display, commonly known as gummy smile, is characterised by a gingival display of more over 3mm when smiling. A patient with a gummy smile was treated with lip repositioning surgery in the current case report. Our goal was to present lip repositioning as a viable treatment technique for reducing gingival display and asymmetry with a simple and conservative surgical procedure, strong long-term durability, and little recurrence.
MANAGEMENT OF PLASMA-DERIVED MEDICINAL PRODUCTS: SUPPLY AND TRACEABILITY ISSUES
Authors:   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Wartiti Mohammed Adnane El , Wafaa Enneffah ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Jihane Ifezouane ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Akrim Jaouad ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Nawal Cherkaoui ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco., Jamal Lamsaouri ,   Mohammed V University of Rabat, Faculty of Medicine and Pharmacy, Rabat, Morocco.
Published: April 2022

Background:Plasma-derived medicinal products (PDMPs) represent a particular field of pharmaceutical industry. Produced mostly from human blood, PDMPs production follows strict procedures for biological safety and traceability. It comes to albumin, immunoglobulins, coagulating fractions, antiprotease fractions as well as biological glues. Resources and procedures: Our study aimed to define PDMPs management in Morocco, as well as their biological safety procedures, while specifying constraints related to their supply and traceability. Results and discussion: Moroccan market supply by PDMPs is ensured by the National Blood Transfusion Center (NBTC) that shipments Moroccan collected plasma to the French Laboratory of Fractionation and Biotechnology (LFB). The latter produces PDMPs for the Moroccan market under an agreement signed in 1999 and PDMPs prices are fixed by a decree of the Ministry of Health. PDMPs production follows strict procedures for biological safety and traceability from blood donations collection to administration in patients, allowing their routes to be retraced in case of hemovigilance or pharmacovigilance alerts. In Morocco, only two traceability labels are provided on the primary packaging of PDMPs, unlike in some other countries where PDMPs are provided with three sticky labels, all essential for mastering products traceability. PDMPs shortages are due to insufficient amount of plasma sent to LFB, which is aggravated in case of batch recall. Conclusion:PDMPs are indicated to support critical patients, which imply mastering biological safety and traceability from production to delivery, and optimizing their supply in order to ensure their availability by emergency times.
DIFFERENCES IN THE PERCEPTION OF POVERTY OF UNIVERSITY STUDENTS / DIFERENCIAS EN LA PERCEPCION DE LA POBREZA DE ESTUDIANTES UNIVERSITARIOS
Authors:   Instituto Tecnologico de Sonora. Sonora, Mexico., Geraldine Ozuna Beltran Altayra , Adriana Andujo Ozuna Carla ,   Instituto Tecnologico de Sonora. Sonora, Mexico., Maria Castro Gastelum Olga ,   Instituto Tecnologico de Sonora. Sonora, Mexico.
Published: April 2022

The objective of this research is to find significant differences according to the perception of poverty of university students. The perception of poverty has its repercussions in the way ofperceiving the causes of social phenomena such as poverty. Through a sample made up of 100 students from 3 universities, it was found that there are significant differences in aspects such as cultural learning theory, theory of powers that be and deterministic theory. It is concluded that the attribution theory can be used to understand the perception of social phenomena such as the causes of poverty.
SELF-MEDICATION PATTERN OF ANTIBIOTICS AMONG THE PEOPLE OF IMPHAL WEST DISTRICT OF MANIPUR, INDIA
Authors:   Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin code: 795004, India., Ningthoujam Geetanjali , Datta Swagata ,   Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin code: 795004, India., Medhabati Mayanglambam ,   Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin code: 795004, India., Zosangpuii Christina ,   Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin code: 795004, India., Meena Nameirakpam ,   Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, Pin code: 795004, India.
Published: April 2022

Background and aim: Self-medication with antibiotics is one of the growing issues in developing countries. Irrational use of antibiotics leads to development of resistance. Antibiotic resistance is a growing threat in management of infectious disease which leads to morbidity and mortality. Our study is to assess the self-medication pattern of antibiotic among the people of Imphal West district of Manipur. Materials and methods: A cross-sectional study was conducted on 1980 randomly selected people from populations of Manipur during September 2020. Data was collected using modified pre-structured questionnaire. Using SPSS software version 21, descriptive data analysis was done and expressed in frequencies and percentages. Result: In the study, female participants were more than male participants and majority were from the age group 18-30 years, educated and low-income group. Azithromycin was the most commonly used antibiotics followed by amoxicillin and clavulanic acid combination. Majority of them obtained the antibiotics from local pharmacies and was mainly recommended by the pharmacists. Only 16.92% of them faced mild adverse reaction. Around 65.04% of the participant considered that self-medication with antibiotics is not a safe practice. Conclusion: This study showed that antibiotics were easily accessible and many people were not aware about the antibiotic usage and risk of developing its resistance in Imphal West. Higher authorities need to enlighten the public about the rational use of antibiotics and the dangerous effects of self-medication to overcome the antibiotic resistance.
THE SUSTAINABILITYOF HYDROPONIC FARMING:FARMERS VIEW IN INDIA
Authors:   Research Scholar, School of Commerce, Presidency University, Bangalore, Karnataka., B.V Thanushree , Kumar S.V Pradeep ,   Assistant Professor, School of Commerce, Presidency University, Bangalore, Karnataka.
Published: April 2022

The India is a country where fresh fruits and vegetables exported worth Rs.8,06,807.32 lakh and 27,15,601.36 MT in the financial year 2020-21. Refurbishment of agriculture styles and methods to improve productivity is indispensable. Hydroponic farming method is one among them. Hydroponic farming is one the contemporary mode of farming, where crops or plants are grown without soil. In hydroponic farming method the plants are grown in water which is rich innutrients and mineral supply. As the population grows, availability of land for growing food (scale) decreases and to supply sufficient quantity food with minimum land resource may be a challenging task for the country. Hydroponic system is the technology that requires minimum land (i.e. 1/5th of the land required for soil-based farming), water and resources. Crops grown hydroponically will grow faster, healthier, zero carbon food and also it can be grown more organically. In India at initial stage, no estimates are available and most of the projects are in trail and sample stage and also many farmers are struggling because of lack of technology, skills and proper infrastructure for hydroponic farming but this constraint can be removed with the aid of training, education and with skilled labor.Some of the market research in India and business intelligence firm predicts that Indian hydroponic market would likely to grow at annual growth rate of 13.53% between 2020 and 2027*. So its very important to know that where hydroponic farming sustainability in India. In this study we have tried to analyze the hydroponic farming sustainability in India.