bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrastructure and Morphometric Analysis of Interstitial Cells of Cajal in the Gastric Wall of the Bullfrog (Rana catesbeiana)
Authors: Huang Yujie , Gong Meiling , Chen Xianshu , Chen Yijie , Lu Bikai , Ye Yaqiong , Zhao Haiquan , Chen Zhisheng , Zhang Hui
Published: January 2022

Interstitial cells of Cajal (ICC) play a vital role in the gastrointestinal motility. However, information on ICC in lower vertebrates is rare. Here, ICC and ICC-like features of the gastric wall in the bullfrog (Rana catesbeiana) were observed by light microscopy and transmission electron microscopy. The lengths and distances of the ICC/ICC-like features were measured by morphometric analysis. The gastric wall contained mucosa, submucosa, tunica muscularis, and serosa. The gastric glands contained mucous cells and oxynticopeptic cells. The ICC with 1–3 processes were located among smooth muscle cells (SMC) of the tunica muscularis. Moreover, the ICC-like features were observed among oxynticopeptic cells of the mucosa. The processes of ICC established direct contacts with SMC. Also, the gap junctions were observed between the processes of ICC and nerve fiber bundles in the tunica muscularis. The multivesicular bodies, including shedding exosomes, were frequently observed between ICC and SMC. In addition, ICC-like features and their processes were observed in close proximity to oxynticopeptic cells and blood vessels. Our findings illustrated that ICC are present in the gastric tunica muscularis, and ICC-like features were in the mucosal lamina propria of the gastric wall of R. catesbeiana. These histological evidences supported the notion that ICC are implicated in gastric motility.
Primary non-Hodgkin’s lymphoma of the orbit: treatment outcomes from India
Authors: Yadav Budhi Singh , Simha Vjai
Published: January 2022

Background:

Primary non-Hodgkin’s lymphoma (NHL) of the orbit is rare. Orbital NHLs show good response to both radiotherapy (RT) and chemotherapy, and hence, the emphasis should be to ensure maximum cure rate with minimum morbidity. In this study, we present the clinical profile and treatment outcomes of patients with NHL who had initial presentation in the orbit.

Materials and methods:

In this retrospective analysis, case records of patients with a diagnosis of NHL of the orbit were analysed from January 2005 to January 2015. Patients were worked up and staged according to the Ann Arbor system. Patients with large tumours were initially given chemotherapy with CHOP regimen (cyclophosphamide, vincristine, adriamycin and prednisolone) three weekly for 4–6 cycles. Patients with residual disease were given RT 20–30 Gy at 2 Gy per fraction. RT when given as a primary treatment consisted of 36–45 Gy at 1·8–2 Gy per fraction on either Cobalt 60 machine or linear accelerator.

Results:

A total of 52 patients with diagnosis of orbital NHL were included in this study. Median age at presentation was 57 years (range 13–71). Left, right and bilateral orbit was involved in 21 (40%), 28(54%) and 3(6%) patients, respectively. Low- and high-grade pathology was seen in 39(75%) and 13(25%) patients, respectively. On immunohistochemistry, 23(44%) tumors were CD 20 positive. After staging, 33 (63%) patients had stage I disease. Median tumour size was 4·0 × 3·2 × 1·5 cm (1·7 × 1·7 × 1·4 cm to 5·8 × 4·0 × 4·7 cm). Primary RT was given to 7(13%) patients. Upfront chemotherapy was given in 45(86·5%) patients, out of which 24 had stage I disease. RT consolidation was done in 26 (50%) patients for residual disease after chemotherapy. Median follow-up was 88 months (range 29–183 months). Relapse occurred in 6(9·6%) patients; 2 local; 2 local + distant and in 2 distant alone. These patients were successfully salvaged with systemic chemotherapy and local RT. One patient died due to neutropenia. Overall survival in this series was 96%.

Conclusions:

Excellent local control was achieved with initial chemotherapy followed by RT for primary orbital NHL with minimal toxicity. We recommend a dose of 36–40 Gy for definitive RT and 30 Gy for lymphoma following chemotherapy using 2 Gy/fraction for Indian patients who present with bulky tumours. RT should be incorporated in treatment of orbital NHL whenever possible as it is safe, effective and is associated with minimal complications.
Which Picker Fits My Data? A Quantitative Evaluation of Deep Learning Based Seismic Pickers
Authors: Münchmeyer Jannes , Woollam Jack , Rietbrock Andreas , Tilmann Frederik , Lange Dietrich , Bornstein Thomas , Diehl Tobias , Giunchi Carlo , Haslinger Florian , Jozinović Dario , Michelini Alberto , Saul Joachim , Soto Hugo
Published: January 2022

Seismic event detection and phase picking are the base of many seismological workflows. In recent years, several publications demonstrated that deep learning approaches significantly outperform classical approaches, achieving human‐like performance under certain circumstances. However, as studies differ in the datasets and evaluation tasks, it is unclear how the different approaches compare to each other. Furthermore, there are no systematic studies about model performance in cross‐domain scenarios, that is, when applied to data with different characteristics. Here, we address these questions by conducting a large‐scale benchmark. We compare six previously published deep learning models on eight data sets covering local to teleseismic distances and on three tasks: event detection, phase identification and onset time picking. Furthermore, we compare the results to a classical Baer‐Kradolfer picker. Overall, we observe the best performance for PhaseNet, closely followed by EQTransformer and GPD. Furthermore, we conduct a cross‐domain study, analyzing model performance on data sets they were not trained on. We show that trained models can be transferred between regions with only mild performance degradation, but models trained on regional data do not transfer well to teleseismic data. As deep learning for detection and picking is a rapidly evolving field, we ensured extensibility of our benchmark by building our code on standardized frameworks and making it openly accessible. This allows model developers to easily evaluate new models or performance on new data sets. Furthermore, we make all trained models available through the SeisBench framework, giving end‐users an easy way to apply these models.
Changes in Arctic Stratification and Mixed Layer Depth Cycle: A Modeling Analysis
Authors: Hordoir Robinson , Skagseth Øystein , Ingvaldsen Randi B. , Sandø Anne Britt , Löptien Ulrike , Dietze Heiner , Gierisch Andrea M. U. , Assmann Karen M. , Lundesgaard Øyvind , Lind Sigrid
Published: January 2022

Climate change is especially strong in the region of the Arctic Ocean, and will have an important impact on its thermo‐haline structure. We analyze the results of a hindcast simulation of a new 3D ocean model of the Arctic and North Atlantic oceans for the period 1970–2019. We compared the time period 1970–1999 with the time period 2010–2019. The comparison showed that there is a decrease of stratification between the two periods over most of the shallow Arctic shelf seas and in the core of the Transpolar Ice Drift. Fresh water inputs to the ocean surface decline, and inputs of momentum to the ocean increase, which can explain the decrease in stratification. The comparison also showed that the mixed layer becomes deeper during winter, in response to the weakened stratification owing to increased vertical mixing. The comparison of summer mixed layer depths between the two time periods follows a deepening pattern that is less evident. Regional exceptions include the Nansen Basin and the part of the Canadian Basin bordering the Canadian Archipelago, where the mixed layer shoals. Trends of freshwater fluxes imply that the changes of haline stratification in these regions are also influenced by other processes, for example, horizontal advection of fresh water, increased mixing and changes in the underlaying water masses. Runoff increase toward the Arctic Ocean can locally decrease but also increase salinity, and has an impact on stratification which can be explained by coastal dynamics. The results emphasize the non‐linear nature of Arctic Ocean dynamics.
Boundary Layer Characteristics Over Complex Terrain in Central Taiwan: Observations and Numerical Modeling
Authors: Cheng Fang‐Yi , Wang Yu‐Tzu , Huang Mu‐Qun , Lin Pay‐Liam , Lin Ching‐Ho , Lin Po‐Hsiung , Wang Sheng‐Hsiang , Tsuang Ben‐Jei
Published: January 2022

The development of the atmospheric boundary layer and flow circulation becomes complicated over complex terrain. A field campaign involving the acquisition of tethersonde, ozonesonde and 10‐m meteorological tower observations was conducted during September 2–8, 2013, over the Puli Basin located in the mountainous area of central Taiwan to investigate the evolution of the planetary boundary layer (PBL) and flow circulation. In addition, numerical simulations using the Weather Research and Forecasting (WRF) model were performed to examine the three‐dimensional air flow variations. Analysis of the tethersonde data indicated a well‐mixed boundary layer structure and a steady westerly flow over the Puli Basin during the daytime that became further enhanced in the afternoon. The 600‐m resolution WRF model simulation showed that the enhanced wind flow in the afternoon was due to the inland penetration of the onshore sea breeze, which also transported high concentrations of O3 from the western metropolitan area into the basin. During the nighttime, a stable boundary layer formed, above which a nocturnal low‐level jet formed throughout the campaign period in the Puli Basin. The WRF model is able to reproduce the general variations in the wind flows and thermal structures. Furthermore, the diagnostic PBL height estimated based on the critical Richardson number provides an enhanced understanding of the evolutionary characteristics of the PBL over complex terrain.
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas
Authors: Li Jiabo , Wang Xuya , Chen Lulu , Zhang Jinhao , Zhang Yiming , Ren Xiao , Sun Jinzhang , Fan Xiaoguang , Fan Jikang , Li Tao , Tong Luqing , Yi Li , Chen Lei , Liu Jie , Shang Guanjie , Ren Xiude , Zhang Hao , Yu Shengping , Ming Haolang , Huang Qiang , Dong Jun , Zhang Chen , Yang Xuejun
Published: January 2022

Glioblastoma is the most common primary intracranial malignant tumor in adults and has high morbidity and high mortality. TMEM158 has been reported to promote the progression of solid tumors. However, its potential role in glioma is still unclear. Here, we found that TMEM158 expression in human glioma cells in the tumor core was significantly higher than that in noncancerous cells at the tumor edge using bioinformatics analysis. Cancer cells in patients with primary GBMs harbored significantly higher expression of TMEM158 than those in patients with WHO grade II or III gliomas. Interestingly, regardless of tumor grading, human glioma samples that were IDH1-wild-type (IDH1-WT) exhibited higher expression of TMEM158 than those with IDH1-mutant (IDH1-Mut). We also illustrated that TMEM158 mRNA expression was correlated with poor overall survival in glioma patients. Furthermore, we demonstrated that silencing TMEM158 inhibited the proliferation of glioma cells and that TMEM158 overexpression promoted the migration and invasion of glioma cells by stimulating the EMT process. We found that the underlying mechanism involves STAT3 activation mediating TMEM158-driven glioma progression. In vivo results further confirmed the inhibitory effect of the TMEM158 downregulation on glioma growth. Collectively, these findings further our understanding of the oncogenic function of TMEM158 in gliomas, which represents a potential therapeutic target, especially for GBMs.
Optical coherence tomography angiography for the detection of macular neovascularization—comparison of en face versus cross-sectional view
Authors: Siggel Robert , Spital Christel , Lentzsch Anna , Liakopoulos Sandra
Published: January 2022

Purpose

To evaluate sensitivity and specificity of swept source-optical coherence tomography angiography (SS-OCTA) en face images versus cross-sectional OCTA versus a combination of both for the detection of macular neovascularization (MNV).

Design

Prospective cohort study.

Participants

Consecutive patients with various chorioretinal diseases and subretinal hyperreflective material (SHRM) and/or pigment epithelial detachment (PED) on OCT possibly corresponding to MNV in at least one eye.

Methods

102 eyes of 63 patients with fluorescein angiography (FA), OCT and SS-OCTA performed on the same day were included. FA images, the outer retina to choriocapillaris (ORCC) OCTA en face slab, a manually modified en face slab (‘custom slab’), cross-sectional OCTA and a combination of OCTA en face and cross-section were evaluated for presence of MNV.

Main outcome measures

Sensitivity and specificity for MNV detection, as well as the concordance was calculated using FA as the reference.

Results

OCTA en face imaging alone yielded a sensitivity of 46.3% (automated)/78.1% (custom) and specificity of 93.4% (automated)/88.5% (custom) for MNV detection. Cross-sectional OCTA (combination with en face) resulted in a sensitivity of 85.4% (82.9%) and specificity of 82.0% (85.3%). Concordance to FA wasmoderatefor automated en face OCTA (κ = 0.43), andsubstantialfor custom en face OCTA (κ = 0.67), cross-sectional OCTA (κ = 0.66) and the combination (κ = 0.68).

Conclusion

Segmentation errors result in decreased sensitivity for MNV detection on automatically generated OCTA en face images. Cross-sectional OCTA allows detection of MNV without manual modification of segmentation lines and should be used for evaluation of MNV on OCTA.
Point-of-care COPD diagnostics: biomarkers, sampling, paper-based analytical devices, and perspectives
Authors: He Guozhen , Dong Tao , Yang Zhaochu , Branstad Are , Huang Lan , Jiang Zhuangde
Published: January 2022

COPD has become a major disease with great social and economic impacts. To enable point-of-care COPD diagnostics, paper-based analytical device is a promising candidate; however, it requires synergetic studies of biomarkers, biofluids, and sampling.
An enzyme cascade fluorescence-based assay for the quantification of phenylalanine in serum
Authors: Meng Leilei , Hu Rui , Chen Jinping , Yu Tianjun , Cai Xiaopin , Yang Guoqiang , Zeng Yi , Li Yi
Published: January 2022

An enzyme cascade fluorescence assay for phenylalanine quantification was established by the combination of phenylalanine dehydrogenase and nitroreductase.
Understanding the endocrine disruptor and determination of bisphenol A by functional Cu-BTABB-MOF/rGO composite as facile rapid electrochemical sensor: an experimental and DFT investigation
Authors: Ponnada Srikanth , Gorle Demudu Babu , Kiai Maryam Sadat , Raju Chikkili Venkateswara , Faraji Mehrdad , Sharma Rakesh K. , Nowduri Annapurna
Published: January 2022

A pioneering Cu-BTABB-MOF/rGO composite customized electrode is fabricated and utilized as a sensor towards identifying bisphenol A (BPA).
Tetrakaidecahedron-shaped Cu four-core supramolecule as novel high-performance electrode material for lithium-ion batteries
Authors: Chen Xueli , Chen Kongyao , Li Gaojie , Huang Chao , Zhang Yingying , Feng Yanling , Qin Na , Luo Jiahuan , Chen Weihua , Mi Liwei
Published: January 2022

A tetrakaidecahedron-shaped Cu four-core supramolecule was designed as novel lithium storage electrode, which shows excellent rate ability and cyclicity.
Well-organised two-dimensional self-assembly controlled byin situformation of a Cu(ii)-coordinated rufigallol derivative: a scanning tunnelling microscopy study
Authors: Kikkawa Yoshihiro , Nagasaki Mayumi , Tsuzuki Seiji , Fouquet Thierry N. J. , Nakamura Sayaka , Takenaka Yasumasa , Norikane Yasuo , Hiratani Kazuhisa
Published: January 2022

Scanning tunnelling microscopy revealed that thein situmetal coordination of a rufigallol derivative at the solid/liquid interface enables the formation of a well-organized columnar structure.
Mechanism investigation of the enhanced oxygen storage performance of YBaCo4O7+δ synthesized by a glycine-complex decomposition method
Authors: Chen Ting Ru , Hasegawa Takuya , Cho Sung Hun , Goto Tomoyo , Sekino Tohru , Kakihana Masato , Yin Shu
Published: January 2022

Illustration of the reason for the rapid oxygen storage rate of the low-temperature sample.
Hypophosphite addition to alkenes under solvent-free and non-acidic aqueous conditions
Authors: Huang Zhaorui , Chen Yuxuan , Kanan Matthew W.
Published: January 2022

Addition of alkali hypophosphite to alkenes, including electron-deficient substrates, streamlines the synthesis of polyfunctional H-phosphinates.
Pillar[5]arene-derived covalent organic materials with pre-encoded molecular recognition for targeted and synergistic cancer photo- and chemotherapy
Authors: Wang Yang , Wang Di , Wang Jian , Wang Chenwei , Wang Jin , Ding Yue , Yao Yong
Published: January 2022

By combining the precisely sized cavity of pillar[5]arene and photodynamic properties of porphyrin derivatives, novel COMs (P5COMs) as an efficient cancer therapy platform from aldehyde-modified pillar[5]arene (P5CHO) and tetra-(4-aminophenyl)porphyrin (TAPP) were fabricated successfully.
CO2-Activation by size-selected tantalum cluster cations (Ta1–16+): thermalization governing reaction selectivity
Authors: Levin Nikita , Margraf Johannes T. , Lengyel Jozef , Reuter Karsten , Tschurl Martin , Heiz Ulrich
Published: January 2022

Tantalum cluster cations react with CO2 either via transfer of oxygen atoms to the clusters or the adsorption of an entire molecule. The released energy and vibrational heat capacities are assigned to determine the branching ratios of the pathways.
An anisotropic dressed pairwise potential model for the adsorption of noble gases on boron nitride sheets
Authors: John Chris , Swathi Rotti Srinivasamurthy
Published: January 2022

Improvization of the fidelity of intermolecular force fields by an accurate parametrization of anisotropic pair potentials for noble gas–boron nitride systems.
Role of conical intersection seam topography in the chemiexcitation of 1,2-dioxetanes
Authors: Fdez. Galván Ignacio , Brakestad Anders , Vacher Morgane
Published: January 2022

Chemiexcitation of 1,2-dioxetanes is initiated by the cleavage of the O–O bond, then the molecule enters a region where nonadiabatic transitions to excited states are feasible. Does the surface topography explain chemiexcitation yield differences?
ChemSpaX: exploration of chemical space by automated functionalization of molecular scaffold
Authors: Kalikadien Adarsh V. , Pidko Evgeny A. , Sinha Vivek
Published: January 2022

This work introduces ChemSpaX, an open-source Python-based tool for automated exploration of chemical space of molecular scaffolds with a special focus on transition-metal complexes.
Detailed structural and spectroscopic elucidation of ferrocenium coupled N-heterocyclic carbene gold(i) complexes
Authors: Reinhard Garrett L. , Jayaraman Selvakumar , Prybil Joshua W. , Arambula Jonathan F. , Arumugam Kuppuswamy
Published: January 2022

Unambiguous assignment of redox sites on ferrocene coupled N-heterocyclic carbene gold(i) anticancer therapeutic agents is described.
Mechanism study on organic ternary photovoltaics with 18.3% certified efficiency: from molecule to device
Authors: Li Yaokai , Guo Yuan , Chen Zeng , Zhan Lingling , He Chengliang , Bi Zhaozhao , Yao Nannan , Li Shuixing , Zhou Guanqing , Yi Yuanping , Yang Yang (Michael) , Zhu Haiming , Ma Wei , Gao Feng , Zhang Fengling , Zuo Lijian , Chen Hongzheng
Published: January 2022

Our work presents a study on the working mechanism of ternary organic photovoltaic devices based on non-fullerene acceptors, focusing on the composition-dependent optoelectronic property variations in blend films and devices.
High-efficiency, anode-free lithium–metal batteries with a close-packed homogeneous lithium morphology
Authors: Su Laisuo , Charalambous Harry , Cui Zehao , Manthiram Arumugam
Published: January 2022

Advanced electrolytes enable highly efficient anode-free lithium–metal batteries by forming dense, close-packed Li morphology on the Cu anode current collector, which is related to the crystallinity of Li at the beginning of plating.
Simple synthesis of self-assembled nacre-like materials with 3D periodic layers from nanochitin via hydrogelation and mineralization
Authors: Xu Junhua , Liu Liang , Yu Juan , Zou Yujun , Pei Wenhui , Zhang Lili , Ye Wenbo , Bai Long , Wang Zhiguo , Fan Yimin , Yong Qiang , Rojas Orlando J.
Published: January 2022

A one-step ion diffusion process was used to synthesize hydrogel composites with designable, regularly interspaced organic/inorganic strata. “Brick-and-mortar” structures with a strength similar to that of natural nacre were formed after hot pressing.
Patterned microfluidic devices for rapid screening of metal–organic frameworks yield insights into polymorphism and non-monotonic growth
Authors: Coliaie Paria , Bhawnani Rajan R. , Prajapati Aditya , Ali Rabia , Verma Prince , Giri Gaurav , Kelkar Manish S. , Korde Akshay , Langston Marianne , Liu Chengxiang , Nazemifard Neda , Patience Daniel , Rosenbaum Tamar , Skliar Dimitri , Nere Nandkishor K. , Singh Meenesh R.
Published: January 2022

Illustrated is a continuous-flow microfluidic device with patterned surface to induce faster nucleation of metal–organic frameworks (MOFs) and other slow-growing crystals, where the cyclonic flow allows trapping of crystals to grow them under controlled conditions.
SERS tags derived from silver nanoparticles and aryl diazonium salts for cell Raman imaging
Authors: Li Da , Nizard Philippe , Onidas Delphine , Lamouri Aazdine , Pinson Jean , Mahouche-Chergui Samia , Aubertin Kelly , Gazeau Florence , Luo Yun , Mangeney Claire
Published: January 2022

Surface functionalization of silver nanoparticles by Raman reporters derived from aryl diazonium salts offers new opportunities for the design of Surface-Enhanced Raman Spectroscopy (SERS) labels for Cell Raman Imaging
Binder-free mechanochemical metal–organic framework nanocrystal coatings
Authors: Lin Rijia , Yao Yuqi , Zulkifli Muhammad Yazid Bin , Li Xuemei , Gao Shuai , Huang Wengang , Smart Simon , Lyu Miaoqiang , Wang Lianzhou , Chen Vicki , Hou Jingwei
Published: January 2022

A quick, verstile and binder-free technique to generate MOF coatings on various substrates.
RAFT aqueous dispersion polymerization of 4-hydroxybutyl acrylate: effect of end-group ionization on the formation and colloidal stability of sterically-stabilized diblock copolymer nanoparticles
Authors: Beattie Deborah L. , Deane Oliver J. , Mykhaylyk Oleksandr O. , Armes Steven P.
Published: January 2022

Poly(2-hydroxyethyl acrylate)-poly(4-hydroxybutyl acrylate) nano-objects are prepared by aqueous polymerization-induced self-assembly (PISA) using an ionic RAFT agent.
Low-energy electron distributions from the photoionization of liquid water: a sensitive test of electron mean free paths
Authors: Gadeyne Titouan , Zhang Pengju , Schild Axel , Wörner Hans Jakob
Published: January 2022

Our study reveals the detailed influence of elastic and inelastic mean-free paths on the complete photoelectron spectra of liquid water, including the low-energy electron distributions and the reshaping of the primary photoelectron bands.
A C-to-O atom-swapping reaction sequence enabled by Ni-catalyzed decarbonylation of lactones
Authors: Luu Quang H. , Li Junqi
Published: January 2022

We present a strategy for a C-to-O atom swap process enabled by the development of a nickel-catalyzed decarbonylation of lactones. This strategy was successfully applied to modifying the skeleton of a natural product and a pharmaceutical precursor.
Unconventional metabolites in chromatin regulation
Authors: Gapa Liubov , Alfardus Huda , Fischle Wolfgang
Published: January 2022

Chromatin, the complex of DNA and histone proteins, serves as a main integrator of cellular signals. Increasing evidence links cellular functional to chromatin state. Indeed, different metabolites are emerging as modulators of chromatin function and structure. Alterations in chromatin state are decisive for regulating all aspects of genome function and ultimately have the potential to produce phenotypic changes. Several metabolites such as acetyl-CoA, S-adenosylmethionine (SAM) or adenosine triphosphate (ATP) have now been well characterized as main substrates or cofactors of chromatin-modifying enzymes. However, there are other metabolites that can directly interact with chromatin influencing its state or that modulate the properties of chromatin regulatory factors. Also, there is a growing list of atypical enzymatic and nonenzymatic chromatin modifications that originate from different cellular pathways that have not been in the limelight of chromatin research. Here, we summarize different properties and functions of uncommon regulatory molecules originating from intermediate metabolism of lipids, carbohydrates and amino acids. Based on the various modes of action on chromatin and the plethora of putative, so far not described chromatin-regulating metabolites, we propose that there are more links between cellular functional state and chromatin regulation to be discovered. We hypothesize that these connections could provide interesting starting points for interfering with cellular epigenetic states at a molecular level.
DNAJC10 correlates with tumor immune characteristics and predicts the prognosis of glioma patients
Authors: Liu Feng , Tu Zewei , Liu Junzhe , Long Xiaoyan , Xiao Bing , Fang Hua , Huang Kai , Zhu Xingen
Published: January 2022

Background: The role of DnaJ heat shock protein family (Hsp40) member C10 (DNAJC10) in cancers has been reported but its function in glioma is not clear. We reveal the prognostic role and underlying functions of DNAJC10 in glioma in the present study.

Methods: Reverse Transcription and Quantitative Polymerase Chain Reaction (RT-qPCR) was used to quantify the relative DNAJC10 messenger RNA (mRNA) expression of clinical samples. Protein expressions of clinical samples were tested by Western blot. The overall survival (OS) of glioma patients with different DNAJC10 expression was compared by Kaplan–Meier method (two-sided log-rank test). Single-sample gene set enrichment analysis (ssGSEA) was used to estimate the immune cell infiltrations and immune-related function levels. The independent prognostic role of DNAJC10 was determined by univariate and multivariate Cox regression analyses. The DNAJC10-based nomogram model was established using multivariate Cox regression by R package ‘rms’.

Results: Higher DNAJC10 is observed in gliomas and it is up-regulated in higher grade, isocitrate dehydrogenase (IDH)-wild, 1p/19q non-codeletion, O(6)-methylguanine-DNA methyltransferase (MGMT) unmethylated gliomas. Gliomas with higher DNAJC10 expression present poorer prognosis compared with low-DNAJC10 gliomas. The predictive accuracy of 1/3/5-OS of DNAJC10 is found to be stable and robust using time-dependent ROC model. Enrichment analysis recognized that T-cell activation and T-cell receptor signaling were enriched in higher DNAJC10 gliomas. Immune/stromal cell infiltrations, tumor mutation burden (TMB), copy number alteration (CNA) burden and immune checkpoint genes (ICPGs) were also positively correlated with DNAJC10 expression in gliomas. DNAJ10-based nomogram model was established and showed strong prognosis-predictive ability.

Conclusion: Higher DNAJC10 expression correlates with poor prognosis of glioma and it was a potential prognostic biomarker for glioma.
The PHANGS-MUSE survey
Authors: Emsellem Eric , Schinnerer Eva , Santoro Francesco , Belfiore Francesco , Pessa Ismael , McElroy Rebecca , Blanc Guillermo A. , Congiu Enrico , Groves Brent , Ho I-Ting , Kreckel Kathryn , Razza Alessandro , Sanchez-Blazquez Patricia , Egorov Oleg , Faesi Chris , Klessen Ralf S. , Leroy Adam K. , Meidt Sharon , Querejeta Miguel , Rosolowsky Erik , Scheuermann Fabian , Anand Gagandeep S. , Barnes Ashley T. , Bešlić Ivana , Bigiel Frank , Boquien Médéric , Cao Yixian , Chevance Mélanie , Dale Daniel A. , Eibensteiner Cosima , Glover Simon C. O. , Grasha Kathryn , Henshaw Jonathan D. , Hughes Annie , Koch Eric W. , Kruijssen J. M. Diederik , Lee Janice , Liu Daizhong , Pan Hsi-An , Pety Jérôme , Saito Toshiki , Sandstrom Karin M. , Schruba Andreas , Sun Jiayi , Thilker David A. , Usero Antonio , Watkins Elizabeth J. , Williams Thomas G.
Published: January 2022

We present the PHANGS-MUSE survey, a programme that uses the MUSE integral field spectrograph at the ESO VLT to map 19 massive (9.4 <  log(M⋆/M⊙)< 11.0) nearby (D ≲ 20 Mpc) star-forming disc galaxies. The survey consists of 168 MUSE pointings (1′ by 1′ each) and a total of nearly 15 × 106spectra, covering ∼1.5 × 106independent spectra. PHANGS-MUSE provides the first integral field spectrograph view of star formation across different local environments (including galaxy centres, bars, and spiral arms) in external galaxies at a median resolution of 50 pc, better than the mean inter-cloud distance in the ionised interstellar medium. This ‘cloud-scale’ resolution allows detailed demographics and characterisations of H IIregions and other ionised nebulae. PHANGS-MUSE further delivers a unique view on the associated gas and stellar kinematics and provides constraints on the star-formation history. The PHANGS-MUSE survey is complemented by dedicated ALMA CO(2–1) and multi-band HST observations, therefore allowing us to probe the key stages of the star-formation process from molecular clouds to H IIregions and star clusters. This paper describes the scientific motivation, sample selection, observational strategy, data reduction, and analysis process of the PHANGS-MUSE survey. We present our bespoke automated data-reduction framework, which is built on the reduction recipes provided by ESO but additionally allows for mosaicking and homogenisation of the point spread function. We further present a detailed quality assessment and a brief illustration of the potential scientific applications of the large set of PHANGS-MUSE data products generated by our data analysis framework. The data cubes and analysis data products described in this paper represent the basis for the first PHANGS-MUSE public data release and are available in the ESO archive and via the Canadian Astronomy Data Centre.
Spheroidal force-free neutron star magnetospheres
Authors: Pétri J.
Published: January 2022

Context. Fast rotating and self-gravitating astrophysical objects suffer strong deformations from centrifugal forces. If, moreover, they are magnetised, they generate an electromagnetic wave that is perturbed accordingly. When stellar objects are also surrounded by an ideal plasma, a magnetosphere is formed. For neutron stars, a relativistic magnetised wind is launched, efficiently extracting rotational kinetic energy flowing into particle creation and radiation.

Aims. We study the electromagnetic configuration of a force-free magnetosphere encompassing an ideal spheroidal rotating conductor as an inner boundary. We put special emphasis on millisecond period neutron star magnetospheres, that is those showing a significant oblate shape. For completeness, we also investigate the effect of prolate stars.

Methods. Force-free solutions were computed by numerical integration of the time-dependent Maxwell equations in spheroidal coordinates using pseudo-spectral techniques. Relevant quantities such as the magnetic field structure, the spin-down luminosity, the polar cap rims, and the current density are shown and compared to the force-free spherical star results.

Results. We find that the force-free magnetic field produced by spheroidal stars remains very similar to their spherical counterpart. However, the spin-down luminosity slightly decreases with increasing oblateness or prolateness. Moreover, the polar cap area increases and, for the most part, always encompasses the equivalent spherical star polar cap rims. The polar cap current density is also drastically affected.

Conclusions. Neutron stars are significantly distorted by either rotational effects such as millisecond pulsars or by magnetic pressure such as magnetars and high magnetic field pulsars. An observational interpretation of and fitting a thermal X-ray pulsation will greatly benefit from an accurate and quantitative analysis similar to the one presented in this paper. However, even for the fastest possible rotation, the effect would certainly be unobservable, in the sense that we cannot predict what feature of the light curve would supposedly reveal the neutron star deformation due to fast rotation.
Occupational safety issues related to computer equipment installation, maintenance and use
Authors: Badea Daniel Onuț , Darabont Doru Costin , Bucerzan Dominic , Trifu Alina , Smîdu Eduard , Bulboacă Eugenia , Haralambie Vergilică
Published: January 2022

This paper presents the findings of an ongoing INCDPM project developed in collaborations with BB Computers that addresses the occupational safety issues related to computer equipment installation, maintenance and use, with emphasis on risk identification. The method used was The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Using the chart flow and the list of items of this method, a literature search was conducted in Science Direct Freedom Collection, Elsevier database, Web of Science - Core Collection, Springer Link Journals. Keywords such as occupational risks, computer equipment installation, computer maintenance were used to retrieve relevant studies which explicitly reported on occupational risks related to computer equipment installation, maintenance and use. The literature search yielded 900 references, of which 20 articles were selected for full-text screening as specified by the inclusion criteria, and ultimately 10 were included in this review. It was developed an extensive and comprehensive list of occupational risks related to computer equipment installation, maintenance and use. After a classification of the equipment in calculation and processing equipment, electronic displays, printer, special printers network equipment the main risks identified in all categories mentioned above are as follows: electric shock, stress, high workload, slips and trips.
Occupational risk management of equipment intended for charging electric vehicles
Authors: Buica Georgeta , Antonov Anca Elena , Beiu Constantin , Dragoș Pasculescu , Dobra Remus
Published: January 2022

Implementing the objectives set at the European and national level to minimize dependence on fossil fuels and mitigate the impact of transport on the environment by introducing fiscal facilities has led to an increase in the market for electric vehicles. This increase requires the development and expansion of charging infrastructure for electric vehicles. The transition from the supply of classic fuel vehicles to the electric ones led to the elimination of some risks and the appearance of new risks for the charging stations’ maintenance staff and the users. The study presents research on the identification of technical and safety requirements specific to a category of work equipment used to charge electric vehicles - charging stations. The technical and safety requirements applicable to electric vehicle charging stations have the role of providing the criteria underlying the management of the necessary risk management of both manufacturers and users and entities that ensure the maintenance of this equipment to adopt highly technical solutions.
Implementation of the Romanian Mining Strategy 2017-2035, with special regard to pit coal: failure or abandonment?
Authors: Roman Liliana , Georgescu Mircea
Published: January 2022

Jiu Valley is currently the only national mining basin capable of producing pit coal. Romania has undergone an extensive industrial restructuring in the last 30 years, including mining, which has led to job losses, generated economic-social and environmental effects that have severely affected the quality of life of the inhabitants of mining communities. As a consequence, the Mining Strategy of Romania 2017 - 2035 was elaborated. The paper analyses the objectives, measures and actions provided in the strategy related to the exploitation of pit coal, putting, face to face, the true state of the mines and the inhabitants of Jiu Valley. 4 years after the elaboration of the Strategy, it is clear that it has not yet come to life: mines are still being closed, there is no clear vision for the sustainable development of mining communities, the mine closure process, the greening of post-closure areas is difficult or not at all, research (e.g. capture of methane from coal), development and innovation are not stimulated, the operation of coal-fired power plants is endangered, with major implications on the supply of inhabitants with heating and of domestic hot water -resulting in major discomfort for locals.
Restructuring of coal mining in Romania between the climate crisis and the energy transition
Authors: Tomescu Cristian , Cioclea Doru , Boanta Cornel , Morar Marius
Published: January 2022

The Romanian energy market is dependent on about a third of total production on the use of fossil fuels, hard coal and lignite and natural gas, especially in the winter months or dry summers, coal still being of strategic importance in producing electricity and ensuring energetic security. However, the sharp changes in climate in recent years have led to the conclusion of environmental agreements, with objectives aimed at long-term strategies to reduce greenhouse gas emissions and which clearly require a reduction in the capacity to produce one kilowatt of thermal energy and identify solutions for transition to clean energy. Where will the Hunedoara Energy Complex and the Oltenia Energy Complex be located in this context? This paper aims to analyze the process of restructuring coal mining, the competitiveness of coal in the electricity mix and possibly the future prospects of restructured mining areas.
Background-oriented schlieren technique in experimental research regarding the effect of explosion pressure
Authors: Șimon-Marinică Adrian Bogdan , Vlasin Nicolae-Ioan , Manea Florin , Popescu Dorin
Published: January 2022

In the following paper, experimental results regarding the effect of explosion pressure are obtained from open field experiments with detonation of explosive charges. In addition, sensors that can be used for security applications for the detection of toxic and explosive compounds, as well as mobile systems for the detection of shock waves due to explosions were used to acquire more detailed results. Sensors are the main components in products and systems used to detect chemicals and volatile organic compounds (VOCs) targeting applications in several fields, such as: industrial production and the automotive industry (detection of polluting gases from cars, medical applications, indoor air quality control. The sensory characteristics of a robot depend very much on its degree of autonomy, the applications for which it was designed and the type of work environment. The sensors can be divided into two categories: internal status sensors (sensors that provide information about the internal status of the mobile robot); external status sensors (sensors that provide information about the environment in which the robot operates). Another classification of these could be: distance sensors, position sensors, environmental sensors - sensors that provide information about various properties and characteristics of the environment (example: temperature, pressure, color, brightness), inertial sensors.
Determination of non-hazardous areas in terms of seismic effect for the use of explosives in the open pit in safe conditions
Authors: Gheorghiosu Edward , Rus Daniela , Ilici Ștefan , Mihai Sorin
Published: January 2022

In addition to the technical and economic advantages of blasting rocks from open-pit mining, this method of extraction can produce effects with a direct impact in the area near the open pit. Blasting works generates effects such as seismic waves that cause vibrations, rock throws, noise and toxic gases. When their intensity and scope are not systematically evaluated and analysed, blasting works can cause serious consequences for people, civil / industrial buildings, the environment, thus affecting the health of the population and the stability / integrity of the buildings / slopes in the vicinity of the mining operations. The paper presents design / determination methods of areas where explosives may / may not be used in conditions of maximum safety in terms of seismic intensity, thus protecting the population and the civil / industrial objectives in the area of the mining work. The obtained results are extracted from a research study carried out for the opening in operation of a new mining deposit, having as reference calculations and theoretical interpretations related to the conditions established for the development of the blasting works.
Technical solutions for the evaluation of the effect of explosion pressure when detoning various explosive loads in view of increasing the degree of societal security
Authors: Jitea Ilie-Ciprian , Laszlo Robert , Miclea Olga , Darsy Anton , Popescu Claudius
Published: January 2022

The scientific article highlights the synthesis of the research results to assess the effect of explosive pressure on the detonation of various quantities of explosives in order to ensure a predictable level of societal security. The results of the experimental researches highlighted in the scientific papers were obtained following the tests with explosive materials performed on different specially configured experimental assemblies in order to analyze the propagation of the pressure wave on a mobile platform with specially configured pressure and gas sensors as well as on the explosion pressure measuring sensors within two modern Kistler systems. The visualization of air pressure waves for the experiments performed with these working montages was done by using a high-speed camera based on the BOS effect applied on fast video filming with adequate quality characteristics on the number of frames per second and the resolution obtained.
Evaluation of the mechanical resistance of rheophores of the means of initiation for explosive’s materials, on the basis of the resistance to abrasion determined with the OPVA 10 specialized equipment
Authors: Radeanu Cristian , Vasilescu Gabriel , Miron Claudia , Vedinas Florin , Radermacher Ladislau
Published: January 2022

The scientific paper presents the synthesis of research results undertaken to develop the technical and methodological infrastructure for assessing the safety of means of initiating explosives, on the abrasion resistance of rheophores of electric detonators, in order to increase the safety of their use. The state-of-the-art OPVA 10 equipment is used to test the ability of rheophores insulation to withstand the abrasion forces that may occur during normal use. This equipment with a programmable automatic ensures the testing of the rheophores of the electric detonating staples to determine the abrasion resistance under the operating conditions provided by the harmonized European standard EN 13763-4 and the technical specification of the manufacturer, the operating temperature of this equipment being between 10 ÷ 30 °C ensuring at the highest level the fulfillment of the technical requirements imposed by the European and international regulations in the field.
Evaluation of equipment used in Ex atmospheres - interdisciplinary field
Authors: Burian Sorin , Grecea Danut , Pupazan Gabriela
Published: January 2022

The risk of explosion becomes significant when, in the industrial field, flammable substances such as gases, vapours, mists, dusts, lint and fibres may be present. If they are present in sufficient quantity, the risk of explosion is imminent. On the other hand, the measure of shutting down the technical equipment, in the context of the presence of explosive atmospheres, is not an acceptable measure in all situations. As examples are the parts of installations that have safety functions: ventilation installations, installations for monitoring the concentration of flammable substances and other safety parameters. Explosion protection of technical equipment shall be evaluated and tested in order to validate it. The testing process of the technical equipment for the purpose of explosion protection certification is situated at the confluence of several engineering fields: mechanical, electrical, chemical, etc. The first part of the paper deals with the risk of explosion and presents the explosion protection of the technical equipment. The systematized presentation of the technical equipment tests is performed in the second part of the paper. Among the conclusions it is mentioned that although the field of tests in explosion atmospheres is an interdisciplinary one, its coherence is ensured by the specific standards.
Using FPGA reconfigurable integrated circuits for monitoring, controlling and managing industrial processes in potentially explosive atmospheres
Authors: Colda Cosmin , Marc Gheorghe , Burian Sorin , Darie Marius
Published: January 2022

The implementation of calculation architectures, data acquisition and processing systems, VLSI type integrated circuits within driving systems shows and increased trend in the industry, due to the advantages of such circuits compared to microcontrollers and ASIC’s. In the first part of the paper is presented functional aspects of reconfigurable integrated circuits for monitoring, controlling and managing industrial processes. Compact RIO is a device developed by National Instruments and which is intended for monitoring and controlling industrial processes. This is also an “embedded” type system, which comprises a FPGA device, a processor with real-time operating system (RTOS) and various input-output modules which have to be attached by the user. Applications using such devices, usually also use an HMI (human machine interface) for creating a graphical interface with the user. The second part of the paper is allocated for establishing the requirements for using of such system in the explosive atmospheres. The practical achievement consists in the construction of a wirelessly PC-controlled robot and the analysis of measurements achieved, respectively data acquired from sensors and video recordings. Among conclusions is highlighted the opportunities brought by the use of the intrinsic safety and flame proof types of protection.
Applying the PRISMA method for obtaining systematic reviews of occupational safety issues in literature search
Authors: Trifu Alina , Smîdu Eduard , Badea Daniel Onuț , Bulboacă Eugenia , Haralambie Vergilică
Published: January 2022

This paper presents the work of 5 PhD students in elaboration of their doctoral thesis, especially for the first part of the thesis, namely the state of the art. The method used was The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Using the chart flow and the list of items of this method, a literature search was conducted in Science Direct Freedom Collection, Elsevier database, Web of Science - Core Collection, Springer Link Journals. In this paper are given 2 examples of systematic reviews that were obtained using PRISMA method.