bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Distribution and Morphology of Sediments in Texas Southern High Plains Playa Wetlands
Authors: Villarreal Carlos J. , Zartman Richard E. , Hudnall Wayne H. , Gitz Dennis , Rainwater Ken , Smith Loren M.
Published: March 2023

Playas are depressional geomorphic features on the U.S. High Plains. About 20,000 Southern High Plains playa wetlandsserve as runoff catchment basins, which are thought to be focal points of Ogallala aquifer recharge. Sediments in playas can alter biodiversity services, impede aquifer recharge, and increase evaporative water losses. The purpose of this study was to evaluate the effects of watershed cultivation systems on post-cultural sediment deposition in 3 pairs of cropland/native grassland playas in Briscoe, Floyd, and Swisher counties of Texas. A hydraulic probe was used to collect soil cores to 2 m or to refusal depth at 25 possible locations in each playa. Particle size distribution and soil color effectively identified sediment additions to the playas. Soil color transitions with depth from very dark grayish brown (10YR 3/2) to very dark gray (10YR 3/1) were always found in cropland playas but not in grassland playas. Particle size distribution was more useful in identifying sediment distribution than type. Using a kriging model, sediment volume in each playa was calculated from sediment thicknesses at the sampling locations and from sediment thicknesses interpolated between sampling locations. Sediment volume was directly related to watershed land use with more accumulated sediment in cropped playas than in grassland playas. Erosion of cultivated watersheds near playas contributes sediments that decrease playa depth and can result in increased evaporative water losses and decreased aquifer recharge.
Citation: Villareal CJ, Zartman RE, Hudnall WH, Gitz D, Rainwater K, Smith LM. 2012. Spatial distribution and morphology ofsediments in Texas southern high plains playa wetlands. Texas Water Journal. 3(1):1-13. Available from: https://doi.org/10.21423/twj.v3i1.2070.
Fifth Circuit Decision in The Aransas Project v. Shaw: the Whooping Crane Case
Authors: Gulley Robert
Published: March 2023

Editor’s Note: The opinion expressed in this commentary is the opinion of the individual author and not the opinion of the Texas Water Journal or the Texas Water Resources Institute.
Citation: Gulley RL. 2014. Fifth Circuit Decision in the The Aransas Project v. Shaw: The Whooping Crane Case. Texas Water Journal. 5(1):55-58. Available from: https://doi.org/10.21423/twj.v5i1.7010.
Texas groundwater rights and immunities: from East to Day and beyond
Authors: Drummond Dylan O.
Published: March 2023

For well over a century, the debate has raged over what interest, if any, landowners possess in the groundwater beneath their property, as well as what degree of tortious immunity a neighboring landowner enjoys for draining adjoining groundwater. After the Texas Supreme Court’s 2012 decision in Edwards Aquifer Authority v. Day, and the Texas Legislature’s 2011 amendments to the Texas Water Code, these debates appear to have been finally settled—for now!
This article traces the jurisprudential development of Texas groundwater law, from its earliest origins in ancient Rome through to the most influential and substantive decisions of the Texas Supreme Court and legislation from the Texas Legislature. It also examines what cases are on the horizon that may yet affect Texas groundwater law in the coming years.
Citation: Drummond DO. 2014. Texas groundwater rights and immunities: from East to Day and beyond. Texas Water Journal. 5(1):59-94. Available from: https://doi.org/10.21423/twj.v5i1.7013.
Conjunctive groundwater management as a response to socio-ecological disturbances: a comparison of 4 western U.S. states
Authors: Sugg Zachary Paul , Ziaja Sonya , Schlager Edella C
Published: March 2023

Recent severe droughts in U.S. western and Great Plains states have highlighted the challenges that socio-ecological disturbances can pose for governing groundwater resources, as well as the interconnections between groundwater and surface water and the need to manage the 2 in an integrated way. Conjunctive management recognizes these interconnections and can be used to mitigate disturbances and achieve a variety of water management goals. However, comparative studies of how and to what extent various states have implemented conjunctive management strategies are few. Here we compare and assess the use of conjunctive management practices in 4 western states—Arizona, California, Nebraska, and Texas—with a particular focus on groundwater. Special attention is paid to factors of geography and infrastructure, degree of administrative (de)centralization, and monitoring and modeling in relation to conjunctive management. Despite the commonality of bifurcated regimes for groundwater and surface water, all 4 states have responded to disturbances with conjunctive management strategies in various ways. Although it has groundwater management challenges similar to those in the other 3 states, Texas has overall been slower to adopt conjunctive management strategies.
Citation: Sugg ZP, Ziaga S, Schlager EC. 2016. Conjunctive groundwater management as a response to socio-ecological disturbances: a comparison of 4 western U.S. states. Texas Water Journal. 7(1):1-24. Available from: https://doi.org/10.21423/twj.v7i1.7019.
Peak flow trends highlight emerging urban flooding hotspots in Texas
Authors: Berg Matthew
Published: March 2023

In the aftermath of flooding disasters, a temptation is to pursue recovery while also dismissing the event as unlikely to recur. Is it possible that underlying streamflow trends, which often avoid detection, help explain individual flooding episodes and should influence future expectations? How do impoundments (dams) affect these trends? Our study provides a comparative analysis to answer these key questions that help determine whether flood planning will be successful. Examining the 25 largest Texas metropolitan areas, we assessed peak flow trends for stream gages having at least 25 years of data. Of 181 total gages, 34 (18.8%) exhibited significant upward trends. Over 85% of those with upward trends are located in the Dallas-Fort Worth-Arlington (17.6%) and Houston-The Woodlands-Sugar Land (67.6%) areas. Approximately 62% of gages with upward trends are in Harris County. Among 84 sites impacted by impoundment, 11 (13.1%) still exhibited upward trends. These findings show that increasing peak flows underlie recent flooding in some areas, spotlighting streams in greatest need of examination. Increasing peak flows in some locations even after impoundment suggest dams might not be a complete solution. Finally, maintaining a robust monitoring network is critical to flood planning, and analysis is hampered when data are lacking.
Citation: Berg MD. 2018. Peak flow trends highlight emerging urban flooding hotspots in Texas. Texas Water Journal. 9(1):18-29. Available from: https://doi.org/10.21423/twj.v9i1.7068.
Water security for Texas: a post-secondary education pathway for water workforce readiness
Authors: Rosen Rudolph A , Cifuentes Luis A , Fischer James , Marquise Howard , Tracy John C
Published: March 2023

Water and wastewater industry leaders in Texas and throughout the United States have expressed concern over high rates of retirement eligibility and difficulties finding and attracting workers ready to fill job openings, especially for work in smaller systems. In late January 2018, the U.S. Government Accountability Office released a report on water workforce readiness and a bill was introduced in the U.S. Senate to establish a water infrastructure workforce development program. Concern over existing education of workers in water and demographic information projecting future workforce readiness are commonly cited as signaling a coming crisis for the water industry. An alignment of post-secondary training and industry needs is recommended to meet coming workforce employment requirements for Texas and the nation. A model post-secondary education pathway for water science and technology is described to support water workforce readiness.
Citation: Rosen RA, Cifuentes LA, Fischer J, Marquise H, Tracy JC. 2018. Water security for Texas: a post-secondary education pathway for water workforce readiness. Texas Water Journal. 9(1):120-128. Available from: https://doi.org/10.21423/twj.v9i1.7078.
Reflexiones curriculares para una educación socialmente responsable
Authors: Puerta Araque Natalia , Barreto Cruz Miguel Alejandro , Guacaneme Duque Natalia
Published: March 2023

El presente ensayo plantea una reflexión desde el pensamiento crítico sobre el papel del currículo en el desarrollo de una educación socialmente responsable, a la luz de las vivencias de maestros y alumnos; tiene como objetivo central analizar la importancia de transformar las visiones curriculares en perspectiva del rol del maestro, los desafíos de la cultura y el papel que deben asumir quienes hacen parte de una propuesta formativa. En esencia, se parte del supuesto de estudiantes que puedan asumir posturas claras, argumentarlas y finalmente llevarlas a la práctica en aras de contribuir al mejoramiento de su proyecto de vida, y en consecuencia, se logren cambios que trasciendan su devenir social y todo su entorno. Todo lo anterior refleja el centro de interés del Semillero de Responsabilidad Social Educativa – RSed, de UNIMINUTO- Bello.
Modeling the Processes of a Complex Socio-Economic System and Strategic Development Priorities
Authors: Zhuravlev Denis , Chaadaev Vitaly
Published: March 2023

To change the economic processes and stabilize the socio-political situation, the authorities need an effective set of tools and methods of socio-economic management. They require new and better means of strategic planning that provide a controlled development of the national economy. This research features advanced forms and methods of econometric modeling in the regional socio-economic system. The research relied on the strategizing methodology developed by Professor V.L. Kvint, as well as the Strategist’s Office software that makes it possible to construct mathematical models of economic processes for a particular region. The predictive analytical model covered ten basic economic processes. This article introduces some factors and indicators defined for the transport infrastructure based on the index approach. The experimental part focused on the case of the North-Western and Volga Federal Districts. The set of tasks for regional development strategizing ranges from the theoretical and methodological provisions to the development of a digital twin of a regional economic system designed with the help of tools that provide information support for analysis, assessment, and forecasting. Regional strategizing is considered as a model of a regional socio-economic system defined as a structure that includes a number of autonomous subsystems with certain objective and measurable indicators.
Tourism, Industrial Exhibitions, and Trade Fairs in the Russian Far East: Strategic Assessment of the Potential for Development
Authors: Sadovnichaya Anna , Chkhotua Ilona
Published: March 2023

The Russian Far East possesses an enormous natural and economic potential, however, its sectoral structure is represented mainly by extractive and manufacturing industries. Certain limiting factors impede the economic development of this microregion and the implementation of its strategic development priorities. Tourism and exhibition and trade fair activities are the largest inter-industry complexes with a significant multiplier effect on the local strategic goals. The research featured tourism and exhibition and trade fair activities as both interconnected and independent complexes that stimulate the economic growth, increase employment, and improve the quality of life in the Russian Far East. The authors assessed the regional potential for tourism, recreation, exhibitions, and trade fairs based on all resources available, their territorial combinations, the local economic turnover, and the needs of the local population and tourists. The analysis provides a comprehensive and systematic solution to such major issues as economic diversification, emigration, long-term economic growth, and the quality of life in the region. If the sphere of tourism, exhibitions, and trade fairs acquires substantial state support, the microregion will be able to implement a number of breakthrough projects in these industries. The Russian Far East will be able to meet the goals of its strategic development only if the federal and local authorities realize the socio-economic importance of tourism, industrial exhibitions, and trade fairs.
Laser Lock-in Thermography for Inspection of Silver-Sintered Die Attaches
Authors: Panahandeh S , May D , Grosse-Kockert C , Wunderle B , Abo Ras M
Published: March 2023

In this study, we demonstrate the capabilities of lock-in thermography (LIT) for the inspection of sintered chip interconnections. The laser LIT technology is used to detect delamination in the sintered layer between copper pad and SiC chip. This work will present a LIT system for the failure analysis (FA) without spray coating for industrial inspections of electronic components with thin layers, low emissivity surfaces, and high conductivity, which may produce thermal failure contrast even below noise level of the IRcamera systems
Toward the development of intelligent wayside hot bearings detector system : combining the thermal vision with the strength of YOLO-v4
Authors: Merainani B , Toullier T , Zongo B , Sriranjan S , Zanaroli S , Guiraud M , Dumoulin J
Published: March 2023

Overheated rail-road car wheels and bearings known as hot boxes, are a major threat for any railway operation. A hot box can lead to fractures of axle journals and might cause grave accidents if not detected in time. This paper proposes to automatically detect, track and count the hot boxes in infrared thermal image sequences (IRTIs), acquired with two infrared camera types, cooled camera (CC) and uncooled camera (UC), through a modified YOLO-v4 framework. In-service experiments have been carried out on freight and passenger trains. The training and testing sets are generated, including original and augmented IRTIs with a resolution of 448 × 239 pixels for CC and 640 × 240 pixels for the UC. The trained models, titled Y-CC and Y-UC, perform in a promising way in regards to detection precision, recall and F1-score
Hypoxia-induced Long Non-coding RNA LSAMP-AS1 Regulates ceRNA
Network to Predict Prognosis for Pancreatic Cancer
Authors: Li Lincheng , Zou Wenbo , Xiao Zhaohui , Deng Zhaoda , Liu Rong
Published: March 2023

Background:

The limited efficacy of chemotherapy and immunotherapy for pancreatic
cancer is thought to be largely influenced by the surrounding cancer microenvironment. The hypoxic
microenvironment caused by insufficient local blood supply is very important. However, the
method to assess the level of hypoxia in the microenvironment of pancreatic cancer (PC) remains
unclear.

Methods:

In our research, we downloaded transcriptomic and clinicopathological data from the
Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). A prognostic model was
developed using univariate and multivariate Cox regression. The ConsensuClusterPlus R package
was used to consistently cluster PC samples through unsupervised clustering. Gene set variation
analysis (GSVA) was performed to identify the different functional phenotypes. The CIBERSORT
evaluated the infiltration status of immune cells. qRT‐PCR was performed to detect the expression
of genes in PC cells and tissues.

Results:

A preliminary risk model was developed to reflect the hypoxic environment of pancreatic
cancer. We found that a high hypoxia risk score indicated poor long-term survival and the presence
of an immunosuppressive microenvironment. In addition, based on prognostic hypoxia-related
genes, 177 PC samples were divided into two subtypes. Compared with cluster 2, cluster 1 was defined
as the "hypoxic subgroup". The infiltration of CD8 T cells, activated memory CD4 T cells,
naive B cells, memory B cells, plasma cells, and neutrophils were lower in cluster 1, suggesting
that there was significant immunosuppression in cluster 1. Beyond that, we constructed a ceRNA
regulatory network composed of differentially expressed lncRNA, miRNA, and mRNA. LSAMPAS1/
hsa-miR-129-5p/S100A2 has been identified as a key ceRNA network that regulates the hypoxic
environment and the prognosis of PC. Notably, in our study, qRT-PCR revealed the relative
expression of LSAMP-AS1 and S100A2 was significantly upregulated in PC cells and tissue.

Conclusion:

The hypoxia-related prognostic risk model and core ceRNA network established in
our study will provide a new perspective for exploring the carcinogenic mechanism and potential
therapeutic targets of pancreatic cancer.
Mother-infant bonding and its predictors among pregnant women in Saudi Arabia
Authors:   Academic Affairs and Training Administration, Ministry of Health, Jazan, Saudi Arabia, Oraybi Laila A. , Yanbaawi Laila O. ,   Primary and Preventive Health Care, Ministry of Health, Al Madinah Al Almunawara, Saudi Arabia
Published: March 2023

The purpose of this study is to identify the predictive factors that encourage mother-infant bonding in pregnant women in the city of Jazan (Saudi Arabia). This is a descriptive cross-section study with 255 pregnant women who filled in the Mother-Infant Bonding Questionnaire, Multidimensional Scale of Perceived Social Support, and Relationship Assessment Scale. Data were analyzed using the t-test, analysis of variance, and regression analysis. The main results showed that pregnant women are generally geared toward a high level of bonding with their infants (3.34±2.080). Regression analysis indicated that a significant portion of the variance in the level of mother-infant bonding among pregnant women was attributed to spousal support, planned pregnancy, and working status. The three variables accounted for 28.6% of the variance in raising mother-infant bonding. This study demonstrated the significance of spousal support and planned pregnancy in the lives of pregnant women. As a result, spousal support during a planned pregnancy may affect feelings and behaviors toward the fetus that are more affectionate, caring, and concerned. Therefore, attention to these factors should be considered in planning to improve mother-infant bonding.
A method for reconstructing models of heat and mass transfer from the spatio-temporal distribution of parameters
Authors: Bykov N. Y.  , Hvatov A.  , Kalyuzhnaya A.  , Boukhanovsky A. V.
Published: March 2023

An algorithm of the generative design method for reconstruction of heat transfer models from the available data is proposed. The method is applied to generate a partial differential equation describing the process of heating and evaporation of a metal, the surface of which is heated by laser radiation. The high efficiency of the method was demonstrated for the purpose of reconstructing the correct structure of the equation, indicating additional processes accompanying heating as phase transitions, and also for determining the values of the temperature-dependent coefficients of the derivatives. Keywords: Generative design method, data-driven model, laser heating, heat conduction equation.
Understanding Recruitment Yield From Social Media Advertisements and Associated Costs of a Telehealth Randomized Controlled Trial: Descriptive Study
Authors: Aily Jéssica Bianca , Copson Jennifer , Voinier Dana , Jakiela Jason , Hinman Rana , Grosch Megan , Noonan Colleen , Armellini Megan , Schmitt Laura , White Mika , White Daniel
Published: March 2023

Background

Recruiting study participants for clinical research is a challenging yet essential task. Social media platforms, such as Facebook, offer the opportunity to recruit participants through paid advertisements. These ad campaigns may be a cost-effective approach to reaching and recruiting participants who meet specific study criteria. However, little is known about the extent to which clicks on social media advertisements translate to the actual consent and enrollment of participants who meet the study criteria. Understanding this is especially important for clinical trials conducted remotely, such as telehealth-based studies, which open the possibility to recruit over large geographical areas and are becoming more common for the treatment of chronic health conditions, such as osteoarthritis (OA).

Objective

The aim of this study was to report on the conversion of clicks on a Facebook advertisement campaign to consent to enrollment in an ongoing telehealth physical therapy study for adults with knee OA, and the costs associated with recruitment.

Methods

This was a secondary analysis using data collected over the first 5 months of an ongoing study of adults with knee OA. The Delaware Physical Exercise and Activity for Knee Osteoarthritis program compares a virtually delivered exercise program to a control group receiving web-based resources among adults with knee OA. Advertisement campaigns were configured on Facebook to reach an audience who could be potentially eligible. Clicking on the advertisement directed potential participants to a web-based screening form to answer 6 brief questions related to the study criteria. Next, a research team member called individuals who met the criteria from the screening form and verbally asked additional questions related to the study criteria. Once considered eligible, an electronic informed consent form (ICF) was sent. We described the number of potential study participants who made it through each of these steps and then calculated the cost per participant who signed the ICF.

Results

In sum, between July and November 2021, a total of 33,319 unique users saw at least one advertisement, 9879 clicks were made, 423 web-based screening forms were completed, 132 participants were successfully contacted, 70 were considered eligible, and 32 signed the ICF. Recruitment costed an average of US $51.94 per participant.

Conclusions

While there was a low conversion from clicks to actual consent, 32% (32/100) of the total sample required for the study were expeditiously consented over 5 months with a per-subject cost well below traditional means of recruitment, which ranges from US $90 to US $1000 per participant.

Trial Registration

Clinicaltrails.gov NCT04980300; https://clinicaltrials.gov/ct2/show/NCT04980300
DESIGNING AND DEVELOPMENT OF GASTRORETENTIVE MUCOADHESIVE MICROSPHERES OF CEFIXIME TRIHYDRATE USING SPRAY DRYER
Authors: CHATURVEDI PRIYANKA , SONI PRAKASH KUMAR , PASWAN SURESH KUMAR
Published: March 2023

Objective: Cefixime is a weakly acidic drug primarily absorbed through the stomach and upper intestinal part and has incomplete absorption in lower GIT which leads to its poor bioavailability. The current research work is aimed to develop gastroretentive mucoadhesive microspheres of cefixime to enhance absorption in the stomach.
Methods: Cefixime trihydrate mucoadhesive microspheres formulation was developed by spray drying technique and optimized by DoE approach using Box-Behnken design. The independent variables selected in the formulation were HPMC K15M (X1) as carrier polymer, Carbopol 971P (X2) as mucoadhesive polymer and Cefixime trihydrate (X3). The response variables studied were mean particle size (R1), and percent cumulative drug release at different time points (R2-R8). The optimized batch was evaluated for mucoadhesion properties, DSC and SEM analysis.
Results: The Ex-vivo test of cefixime microspheres studied on goat intestinal mucosa showed strong mucoadhesion of 82% for an extended period of 6 h. The in vitro drug release studies of microspheres in 0.1 N HCl showed extended release up to 8 h. The DSC thermograph indicated the conversion of the drug from crystalline form to amorphous form following the formation of solid dispersion. SEM analysis reveals the microspheres were spherical and smooth.
Conclusion: It is concluded from the above studies that the current formulation has increased gastric residence time and prolonged release for better absorption of the drug, thus, the formulation will have better therapeutic and increased bioavailability.
FORMULATION AND EVALUATION OF ASPIRIN-LOADED PLGA NANOPARTICLES FOR OPHTHALMIC USE
Authors: PETHE ANIL , SHANBHAG ARYA , SHERJE ATUL , AGRAWAL SURENDRA
Published: March 2023

Objective: The objective of this work was to increase the bioavailability of Aspirin to the retina by increasing its bioavailability to blood. This was achieved by forming aspirin-loaded PLGA nanoparticles
Methods: Aspirin-loaded PLGA nanoparticles were prepared by a solvent evaporation process. The PLGA was dissolved in the proper solvent and added dropwise to the Aspirin-albumin solution revolving at 3000 rpm. Glutaraldehyde was used as a cross-linker at 20% concentration. The nanoparticles were obtained after passing the solution through HPH and subsequent centrifugation.
Results: The prepared nanoparticles were found to be spherical with the smooth surface as seen in SEM. and with a size of 160.9 nm. Aspirin-loaded PLGA nanoparticles showed in vitro drug release of 71.4 % and ex-vivo permeation of 66.2 %. The formulation was found to be stable for six months.
Conclusion: The developed aspirin-loaded polymeric nanoparticles could be effective for the controlled delivery of aspirin in the early prevention of diabetic retinopathy.
ABIRATERONE ACETATE LOADED SOLID LIPID NANOPARTICLES FOR IMPROVED ORAL BIOAVAILABILITY: DESIGN OF EXPERIMENTS BASED FORMULATION OPTIMIZATION, IN VITRO, EX-VIVO AND IN VIVO CHARACTERIZATION
Authors: KONATHAM SURESH , PATANGAY SHASHIKALA
Published: March 2023

Objective: Abiraterone acetate (AA), a BCS Class IV drug, demonstrates biopharmaceutical challenges like polymorphism, poor solubility (<0.5 μg/ml), inconsistent permeability, and low oral bioavailability (<10%) (Hence requires a high dose of 1000 mg/day). The current research’s main objective is to improve oral bioavailability by manufacturing AA-loaded solid lipid nanoparticles (AA-SLNs).
Methods: SLNs were manufactured using hot homogenization followed by an ultra-sonication method. Initial screening of lipids (Glyceryl monostearate (GMS), Glyceryl Monooleate (GMO)), and surfactants (Tween 80 and Span 20) was done by mixture design. Based on statistical analysis, GMO and Tween 80 were selected for further optimization, and Central composite design (CCD) of experiments were done to optimize the composition using particle size, polydispersity index (PDI), encapsulation efficiency (EE), zeta potential, and cumulative % drug release as responses. Comparative ex-vivo and in vivo evaluations of optimized formulation were done with the pure drug and marketed formulation.
Results: Based on the statistical evaluation, GMO-4.4% and Tween 80-3.6% were optimized. Optimized AA-SLNs were found in a spherical shape with size of 286.7±12.6 nm, PDI of 0.138±0.015, EE of 94.0±1.0 %, and zeta potential of-25.0±1.0 mV. Drug release from optimized formulation was extended for 24 h, and ex-vivo permeability was increased by 2.5 and 1.42 times, whereas Relative Oral bioavailability was improved by 6.36 and 1.99 times compared to pure drug and marketed tablets, respectively. 
Conclusion: The results concluded that AA-SLNs showed increased oral bioavailability compared to the pure drug and marketed formulation. Hence the dose of the formulation can be reduced to achieve the desired therapeutic effect.
FORMULATION OF NANOSTRUCTURED LIPID CARRIERS OF HALOPERIDOL PREPARED BY USING CLARIFIED BUTTER
Authors: HARDIKAR SHARWAREE RAJAN , AKBAR ANSARI DANIYAL MOHD , PATIL NILESH ANIL
Published: March 2023

Objective: To develop the nanostructured lipid carriers (NLC’s) using clarified butter.
Methods: Haloperidol-loaded microemulsion templates were prepared by using Smix of Tween 80 and propylene glycol in the ratio 1:2. The selection of the mixture of surfactant and co-surfactant (Smix) and their appropriate proportion were decided by the traditional way of construction of pseudo ternary phase diagrams. 22 factorial design was used to check the amenability of the formulation for its successful scale-up. Sonication time and the amount of Smix were selected as independent variables and their influence on the globular size (Y1) of the microemulsions formed was evaluated by using statistical models. Composition of the optimized microemulsion template was further used to prepare haloperidol-loaded NLC’s by ‘microemulsion quenching method’.
Results: The microemulsion formulations containing Tween 80 as a surfactant and propylene glycol as a co-surfactant exhibited the smallest globular size and hence this composition was used further to implement factorial design as design of experiments. The statistical analysis of the data suggested that the microemulsion formulation can be scaled up successfully. NLC’s were prepared from the optimized microemulsion formulation as template. The globular size of NLC’s was confirmed by Transmission Electron Microscopy and was observed to be in the range of 300 to 600 nm.
Conclusion: The present work suggested that the latency of the clarified butter as a natural blend of solid lipid and liquid lipids can be successfully explored to prepare nanostructured lipid carriers.
Estudio sobre las necesidades y comportamiento informativo de una comunidad indígena
Authors: Calva González Juan José
Published: March 2023

El documento muestra algunos de los resultados de una investigación sobre necesidades y comportamiento informativo de la comunidad indígena purépecha en el pueblo de Cherán en el Estado de Michoacán, México. Este estudio contempló los siguientes objetivos a alcanzar: identificar las necesidades de información; detectar el comportamiento informacional en los aspectos de utilización de dispositivos móviles y acceso a internet, incluyendo las fuentes de información usadas con mayor frecuencia. La muestra de la población fue de 276 personas distribuidas en los siguientes estratos: Estudiante, Docente, Ama de casa, Artesano/a, Señor o jefe de familia, Comerciante, Integrante del Consejo Mayor, Integrante del Consejo de Jóvenes y Coordinador/a de fogata. El periodo de aplicación tomó aproximadamente dos semanas, antes del inicio de la pandemia. Estos resultados presentan las necesidades de información detectadas, pero relacionadas con la edad, el género y la ocupación de las personas encuestadas. Se pretendió que la muestra de la población fuera la adecuada y se aplicó una entrevista estructurada. La investigación está sustentada en las dos primeras fases del Modelo NEIN (modelo sobre las necesidades de información). Los resultados muestran los tipos de información que necesitan los integrantes de esta comunidad y que versan principalmente sobre salud, educación, costumbres, comercio, organización social y compra-venta. Aquéllos toman diferente prioridad dependiendo de la edad, el género, la lengua, la escolaridad y la ocupación de las personas, mostrando que los factores externos e internos impactan sobre los sujetos e influyen en las necesidades de información que presentan. Así mismo ocurre con el comportamiento informativo, que en este caso sólo trata sobre mostrar el uso de dispositivos móviles y el acceso a internet, por un lado, y por el otro, sobre las fuentes a las cuales acuden para buscar la información: recurren principalmente a diferentes tipos de personas, con muy poco uso de la biblioteca.
EFFECTS OF THE ESSENTIAL OIL OF DRIED FRUITS OF PIPER GUINEENSE (PIPERACEAE) ON NEUROLOGICAL SYNDROMES ASSOCIATED WITH CEREBRAL MALARIA IN MICE
Authors: OPOGGEN Tivere Susan , DANIYAN Michael Oluwatoyin , ASIYANBOLA Isaac Damilare , ADEOYE Olufunso Bayo , OYEMITAN Idris Ajayi
Published: March 2023

Background: Cerebral Malaria (CM), is associated with neurological syndromes characterized by cognitive and neurobehavioral abnormalities. Piper guineense Schum and Thonnis known to possess anti-oxidant and central nervous system activities. In this study, effects of essential oil of P. guineense (EOPG) dried fruitson selected behavioral and functional indices in mice with cerebral malaria was evaluated.
Method: Mice with confirmed CM, following intraperitoneal inoculation with 1x107 Plasmodium berghei ANKA parasitized blood in 0.2 ml of normal saline, were randomly allocated into 14 groups (n=12), namely, parasitized control, quinine control, EOPG graded doses (6.25, 12.5, 25, 50, 100 and 150mg/kg), and combination of quinine and EOPG graded doses. Quinine was administered at a dose of 20 mg/kg stat, then 10 mg/kg twice daily for next two days, while EOPG was administered once daily for 3 days, beginning from day 5 post inoculation. Non-parasitized (n=12) and parasitized controls were treated with the vehicle (5% Tween 80 in distilled water). Parasitemia, weight, survival and behavioral assessment using SHIRPA protocol were taken daily.
Results: EOPG showed anti-plasmodial activity in a dose dependent manner, significantly mitigated mortality rate at higher doses (100 and 150mg/kg), and exhibit dose dependent central nervous system protective effects. Also, except for quinine/6.25 mg/kg EOPG, 100% mortality was observed with combination groups, suggesting a potential to precipitate toxicity.
Conclusion: The study concluded that EOPG possesses antimalarial and central nervous system protective effects and may therefore serves to mitigate neurological syndrome in cerebral malaria.
                       
Peer Review History:
Received: 20 December 2022; Revised: 27 January 2023; Accepted: 28 February, Available online: 15 March 2023
Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com
Received file:                             Reviewer's Comments:
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Rima Benatoui,Laboratory of Applied Neuroendocrinology, Department of Biology, Faculty of Science, Badji Mokhtar University Annaba, Algeria.  benattouiryma@gmail.com
Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
Analisis Strategi Pemasaran Pada Era New Normal di Mano Beach House Restaurant Seminyak
Authors: Widiantari Ni Kadek , Amir Firlie Lanovia , Praminatih Gusti Ayu
Published: March 2023

Penelitian ini membahas strategi pemasaran di Mano Beach House Restaurant dengan tujuan untuk menganalis faktor-faktor internal dan eksternal, untuk mengetahui posisi strategi pemasaran yang telah dilakukan, serta untuk mengetahui strategi pemasaran alternatif yang dapat diterapkan di Mano Beach House Restaurant. Teknik pengumpulan data dalam penelitian ini adalah dengan melakukan wawancara, observasi, dokumentasi, dan juga penyebaran kuesioner kepada 4 responden. Teknik analisis data yang digunakan yaitu deskriptif kualitatif, IFAS-EFAS dan analisis SWOT. Hasil penelitian dengan analisis SWOT didapat titik koordinat sumbu X (internal) = 2,65 dan sumbu Y (eksternal) = 1,32 sehingga posisi Mano Beach House berada pada kuadran I, yakni mendukung strategi agresif (growth oriented strategy). Strategi alternatif yang dapat diterapkan oleh Mano Beach House Restaurant adalah dengan memanfaatkan teknologi digital seperti media sosial yang dimiliki dalam meningkatkan kegiatan promosi produk-produk yang dimiliki Mano Beach House Restaurant dengan membuat konten yang menarik dan mengarah kepada positioning perusahaan, serta menjaga dan meningkatkan kerja sama dengan mitra kerja baik travel agent maupun ojek online dalam mempromosikan produk. Ojek online sangat mendukung pendistribusian produk secara online di era New Normal saat ini.
 
This study discusses the marketing strategy at Mano Beach House Restaurant with the aim of analyzing internal and external factors, to determine the position of the marketing strategy that has been carried out, and to find out alternative marketing strategies that can be applied at Mano Beach House Restaurant. Data collection techniques in this study were by conducting interviews, observation, documentation, and also distributing questionnaires to 4 respondents. Data analysis techniques used are descriptive qualitative, IFAS-EFAS and SWOT analysis. The results of the research using SWOT analysis obtained the coordinates of the X axis (internal) = 2.65 and the Y axis (external) = 1.32 so that the position of Mano Beach House is in quadrant I, which supports an aggressive strategy (growth oriented strategy). An alternative strategy that can be applied by Mano Beach House Restaurant is to utilize digital technology such as social media that is owned in increasing promotional activities for the products owned by Mano Beach House Restaurant by creating interesting content that leads to the company's positioning, as well as maintaining and enhancing cooperation. with business partners both travel agents and online motorcycle taxis in promoting products. Online motorcycle taxis strongly support the distribution of products online in the current New Normal era.
PENGARUH POLA ASUH ORANG TUA TERHADAP KEDISIPLINAN DAN HASIL BELAJAR AL ISLAM SISWA KELAS III SD MUHAMMADIYAH 01 BANGKALAN
Authors: Masturoh Ani , Kusuma Rendra Sakbana , Andriani Miranti Widi
Published: March 2023

The Indonesian nation is a nation that is rich in human resources. To provide Contributitons to the nation, we need to give something to our country, one of which is high education this is education has also been regulated in the Constitution, it is important for us to have a high education. Therefore, this research is also for the tield of education, especially primary education. This study aims to determine the effect of parenting on the discipline and learning outcomes the third grade students of SD Muhammadiyah 01 Bangkalan. This study uses a quantitative type of research while the design uses a non-experimental because there is no treatment in this study. In this study, the researcher used a parent response questionnaire, a student response questionnaire, and test questions for students aimed at knowing student learning outcomes. The results of this study can be concluded that based on the results of a simple linear regression test seen from a significance value of less than 0.05. The influence between variables x and y. In this study is a sig value of 0.000, therefore it is said to have an effect between variables x and y.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW TERHADAP HASIL BELAJAR MATEMATIKA SISWA KELAS V DI UPTD SDN LANDAK 1 TANAH MERAH
Authors: Safitri Aullia Dewi , Hariyani Yunita , Kusuma Rendra Sakbana
Published: March 2023

This study aims to determine the effect of the jigsaw type cooperative learning model on mathematics learning outcomes for class V at UPTD SDN Landak 1 Tanah Merah. This research uses a quantitative approach, the type of research is Pre-Experimental Designs One Group Pretest-Postest. The population in this study were all 15 students of class V UPTD SDN Landak 1 Tanah Merah. The t-test shows the correlation coefficient value of 0.796 with a sig value of 0.000 <0.05, it can be interpreted that the hypothesis is accepted. So in this study it can be concluded that there is an effect of the jigsaw type cooperative learning model on the learning outcomes of fifth graders.
Estimate of shadow economy dynamics in Russia and regions: The inflationary aspect
Authors:   Southern Main Branch of the Central Bank of the Russian Federation, Rostov‐on‐Don, Russian Federation, Arzhenovskiy Sergey ,   Rostov State University of Economics, Russian Federation
Published: March 2023

The share of the shadow economy in the GDP of Russia and by region — in the GRP of the regions, was estimated in the study, based on quarterly data. The methodology included two approaches — structural modeling and using of the cash demand model. Estimation of consumer price index elasticity factors by the share of shadow economy in GDP/GRP was carried out. Comparison of empirical results of the study with obtained other authors and other methods, both by country and by region, showed their comparability.
An empirical investigation on investor psychological biases
Authors: Khalaf Bashar Abu
Published: March 2023

The main aim of this paper is to investigate the impact of behavioral biases on the decisions of Jordanian investors. This empirical study investigated the impact of six behavioral finance biases and their impact on Jordanian investors’ financial decisions in the Amman Stock Exchange (ASE). Specifically, this paper empirically examines the impact of cognitive and emotional biases such as overconfidence, representation, availability, loss aversion, anchoring and regret aversion on investors’ financial decisions. Following Chaffai and Medhioub’s (2014) methodology, the paper applied the questionnaire-based approach and managed to collect 693 responses out of 2000 questionnaires (34.65 percent response rate) during the last five years. The main result achieved is that Jordanian investors take their decisions by falling for three main biases such as overconfidence, loss aversion, and anchoring. Jordanian investors believe that their decisions will lead to positive gains even if they are not based on highly developed models that can be used to direct investment strategies.
Challenging Detection of Latent Tuberculosis in a Patient Undergoing High-Dose Corticosteroid Therapy for Acute Hemolytic Anemia and Rhupus Arthropathy
Authors: Ditmars Frederick , Davis John , Greiner Benjamin , Reynoso David
Published: March 2023

In this report, we discuss how autoimmune conditions and associated
immunocompromise may impact diagnostic utility of molecular screening
tools for mycobacterial infection. Imaging, molecular screening, and
clinical judgment are required to rule out disease in the
immunocompromised, especially in an acute setting
No Influence of Threat Uncertainty on Fear Generalization
Authors: Aslanidou Asimina , Andreatta Marta , Wong Alex , Wieser Matthias
Published: March 2023

Fear overgeneralization and perceived uncertainty about future outcomes
have been suggested as risk factors for clinical anxiety. However,
little is known regarding how they influence each other. In this study,
we investigated whether different levels of threat uncertainty influence
fear generalization. Three groups of healthy participants underwent a
differential fear conditioning protocol followed by a generalization
test. All groups learned to associate one female face (conditioned
stimulus, CS+) with a female scream (unconditioned stimulus, US) while
the other face (CS-) was not associated with the scream. In order to
manipulate threat uncertainty, one group (low uncertainty, n = 26)
received 80%, the second group (moderate uncertainty, n = 32) received
60%, and the third group (high uncertainty, n = 30) 40% CS-US
contingency. In the generalization test, all groups saw CS+ and CS-
again as well as four morphs that varied in similarity with the CS+ in
steps of 20%. Subjective (expectancy, valence, and arousal ratings),
psychophysiological (skin conductance response, SCR), and visuocortical
(steady-state visual evoked potentials, ssVEPs) indices of fear were
registered. Participants expected the US in accordance with their
reinforcement schedules but displayed stronger skin conductance with
more uncertainty. However, acquisition of conditioned fear was not
evident in ssVEPs. During the generalization test, we found no effect of
threat uncertainty in any of the measured variables, but the strength of
generalization for threat expectancy ratings was positively correlated
with dispositional intolerance of uncertainty. This study suggests that
mere threat uncertainty does not modulate fear generalization.
Investigation on the adsorption of the carbamate pesticide methomyl from aqueous solution using modified co-beta zeolite particles
Authors: Stojisavljevic Predrag , Vulovic Nikolina , Velickovic Zlate , Mijin Dusan , Stupar Stevan , Dinic Denis , Ivankovic Negovan
Published: March 2023

Adsorption of carbamate pesticide Methomyl by Co-Beta Zeolite particles prepared by wet ion-exchange method from aqueous solutions was studied. The effect of zeolite and pesticide concentrations, pH value, and sintering temperature on pesticide removal from an aqueous solution was studied. The change of methomyl concentration during the adsorption was followed using the UV-Visible spectrophotometer. Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy (SEM-EDS) revealed the modified zeolite morphology and elemental structure. The change of the adsorbent surface before and after dye removal was observed using the Fourier Transformation-infrared spectroscopy (FT-IR). The adsorption kinetics follows the pseudo-second-order kinetics model, and at optimal condition adsorption rate is k1 = 0.0166 g mg-1 min-1. The Langmuir, Freundlich, Temkin and Dubinin-Radushkovich adsorption isotherm models were used to describe the adsorption process. Thermodynamic parameters were also determined using experimental data. The thermodynamic study indicates that during pesticide adsorption is, chemisorption and physisorption are present at the same.
The Bridgman method of (BiAs)2 (TeSe)3 bulk single crystal growth by spontaneous nucleation
Authors: Pozega Emina , Marjanovic Sasa , Vukovic Nikola , Gomidzelovic Lidija , Mitrovic Milijana , Janosevic Milos , Adamovic Dragana
Published: March 2023

The Bi0.5As1.5Te2.98Se0.02 single crystal in 11 mm?80 mm size was grown using the Bridgman method. Energy dispersive spectrometry (EDS) analysis was used to determine the chemical composition of the studied samples, as well as for checking and confirming the homogeneity of the samples. Mobility, concentration of charge majority carriers and Hall coefficient of single crystal, were determined using a Hall Effec system based on the Van der Pauw method. Hall Effect was measured at room temperature with four ohmic contacts and at temperature of liquid nitrogen with silver contacts with an applied magnetic field strength of 0.37 T at different current intensities. The expected improvement in the mobility of obtained single crystal doped with this content of arsenic was not obtained.
Changes in the physicochemical properties of geopolymer gels as a function of NaOH concentration
Authors: Nenadovic Milos , Ivanovic Marija , Kisic Danilo , Bundaleski Nenad , Pavlovic Vera , Knezevic Sanja , Kljajevic Ljiljana
Published: March 2023

In the present paper, polymerization of alkali activated metakaolin (MK) and its structural changing, using 2M NaOH, 8M NaOH, and 16M NaOH solutions were followed by means of X-ray photoelectron spectroscopy (XPS), Diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), Raman spectroscopy and Scanning electron microscopy (SEM). XPS analysis revealed that changing of NaOH concentration did not affect the types of formed bonds in the material. At the same time, the amount of sodium and aluminum increased with the NaOH molarity. The latter steps could be especially interesting because it may indicate the possibility of 'dosing' the amount of Al incorporated by changing the NaOH concentration in the solution. DRIFT analysis revealed that the absorption band for AlIV located at 800 cm-1 is shifted towards the smaller values. Changing the concentration of NaOH, the chemical content did not change, but the structural changes are observed. Raman spectroscopy detected that the most dominant peaks at ~400 cm-1 and 519 cm-1 originate from Si-O-Al and Si-O-Si bending modes. With increasing the NaOH concentration, peaks at 1019-1060 cm-1 become more prominent as a result of polymerization. Both analyzes (DRIFT and Raman) confirmed the presence of quartz. SEM analysis showed that different structures are created by changing the concentration of NaOH.