bluuebunny/crossref_metadata_2025 huggingface dataset:
CT-guided transthoracic needle biopsy of pulmonary lesions: comparison between the cutting needle and aspiration needle
Authors: Huang Zhen-guo , Sun Hong-liang , Wang Cun-li , Gao Bao-xiang , Chen He , Yang Min-xing , Chen Xiao-liang
Published: November 2020

Objectives:

To compare CT-guided transthoracic cutting needle biopsy (TCNB) with transthoracic aspiration needle biopsy (TANB) for pulmonary lesions with respect to the diagnostic accuracy and complication rate.

Methods:

Of the 859 cases that underwent consecutive CT-guided biopsy of pulmonary lesions, 713 cases confirmed by surgical pathology or clinical follow-up were enrolled. Of these, the first consecutive 275 cases underwent TANB, and the remaining 438 received TCNB. The final diagnosis determined the accuracy of biopsy. Based on the post-biopsy CT and clinical medical records, the presence or absence of biopsy-related complications was determined. The χ2 test was used to compare the differences between TCNB and TANB in terms of diagnostic accuracy and complication rate.

Results:

Among the 713 biopsy lesions, the final diagnosis was malignant in 411 cases and benign in 302 cases. As compared to TANB, the diagnostic accuracy of TCNB (98.9% vs 93.8%, χ2 = 14.35, p < 0.01), sensitivity to malignant lesions (97.8% vs 90.6%, χ2 = 10.58, p < 0.01), negative predictive value (97.6% vs 84.8%, χ2 = 19.03, p < 0.01), and specific diagnostic rate for benign lesions (73.4% vs 57.9%, χ2 = 7.29, p < 0.01) were improved. On the other hand, a statistical difference was detected between TCNB and TANB with respect to the incidence of pneumothorax (20.6% vs 13.1%, χ2 = 6.46, p = 0.01), hemorrhage (32.2% vs 13.1%, χ2 = 33.03, p < 0.01), and hemoptysis (8.2% vs 3.3%, χ2 = 6.87, p < 0.01). One patient died just several minutes after TCNB due to severe hemorrhage with hemoptysis.

Conclusions:

Compared to TANB, CT-guided TCNB improves the diagnostic accuracy of pulmonary lesions, but complication rate increases significantly.

Advances in knowledge:

In general, TCNB should be recommended, especially for highly suspicious benign lesions. For patients with small lesions adjacent to vessels or vessels within the lesion, TANB should be considered.
Hepatocellular carcinoma with type II–III portal vein tumour thrombosis: treatment using transarterial chemoembolisation and microwave ablation
Authors: Zhao Wen Peng , Li Honglu , Guo Jiang , Cai Liang , Duan Youjia , Hou Xiaopu , Du Hongliu , Shao Xihong , Diao Zhenying , Li Changqing
Published: November 2020

Objective:

To evaluate the use of transarterial chemoembolisation (TACE) combined with microwave ablation (MWA) to treat patients with hepatocellular carcinoma (HCC) and type Ⅱ–Ⅲ portal vein tumour thrombosis (PVTT) intolerant to targeted drug (TG) therapy.

Methods:

A total of 18 patients with HCC and type Ⅱ–Ⅲ PVTT intolerant to TG were enrolled between June 2015 and December 2019, who were treated with TACE + MWA (MWA group). 24 patients were treated with TACE + TG (TG group; control cohort). Time to progression and overall survival (OS) were analysed along with the incidence of adverse events.

Results:

The median follow-up time was 19.0 months (9.0–32.0 months). The median OS was 17.0 months (8.3–29.3 months; MWA group) and 13.5 months (5.5–22.5 months; TG group) and was not significantly different. The 1- and 2 year OS was also comparable (MWA group: 66.7%, 44.4% vs Target group: 41.7%, 29.2%). Time to progression showed no distinct differences (MWA group: 11.5 months; TG group: 9.0 months) between the two groups. Moreover, the incidence of major Grade 3–4 adverse events in the MWA group (5.6%) was similar to those in the TG group (8.3%).

Conclusion:

TACE + MWA and TACE + TG were comparable in their safety and efficacy in patients with HCC, type Ⅱ–Ⅲ PVTT, and intolerance to TG.

Advances in knowledge:

TACE + MWA can be used as a palliative treatment alternative for TACE + TG in patients with HCC, type Ⅱ–Ⅲ PVTT, and intolerance to TG.
New techniques for studying neurodevelopment
Authors: Escalante Augusto , González-Martínez Rocío , Herrera Eloísa
Published: November 2020

The extraordinary diversity, variability, and complexity of cell types in the vertebrate brain is overwhelming and far exceeds that of any other organ. This complexity is the result of multiple cell divisions and intricate gene regulation and cell movements that take place during embryonic development. Understanding the cellular and molecular mechanisms underlying these complicated developmental processes requires the ability to obtain a complete registry of interconnected events often taking place far apart from each other. To assist with this challenging task, developmental neuroscientists take advantage of a broad set of methods and technologies, often adopted from other fields of research. Here, we review some of the methods developed in recent years whose use has rapidly spread for application in the field of developmental neuroscience. We also provide several considerations regarding the promise that these techniques hold for the near future and share some ideas on how existing methods from other research fields could help with the analysis of how neural circuits emerge.
О ПРАВОВЫХ НОРМАХ РЕГЛАМЕНТИРУЮЩИХ ОТВЕТСТВЕННОСТЬ ПЕРЕВОЗЧИКА ПРИ ПЕРЕВОЗКЕ ГРУЗА
Authors: Melnikova Irina Petrovna , Melnikov Alexander Radiyevich , Melnikova Marina Aleksandrovna , Kostyuchenko Alina Alekseevna
Published: November 2020

В статье проанализированы основные этапы развития законодательно-правовой базы, касающейся ответственности перевозчика за вверенный ему грузовладельцем груз. Рассмотрен перечень конвенциональных документов, регламентирующих ограничение ответственности перевозчика за находящийся в его ведении груз.
ИССЛЕДОВАНИЕ УСЛОВИЙ ДЛЯ ВОЖДЕНИЯ СОЕДИНЕННЫХ ПОЕЗДОВ НА ПОЛИГОНЕ ДВЖД
Authors: Kuzmina Natalya Aleksandrovna
Published: November 2020

В настоящее время ОАО «РЖД» работает в условиях интенсивного роста грузопотоков в направлении портов, пограничных переходов, крупных промышленных предприятий Дальнего Востока. Обусловлено это целым рядом внешнеэкономических факторов и конъюнктурных особенностей. Сырьевой характер экономики России и последствия мирового кризиса вынудили промышленников начать поиск новых рынков сбыта, путь к которым пролегает по международному транспортному коридору Восток – Запад и обеспечивается железной дорогой и Тихоокеанскими портами.За последние пять лет отрасль так и не дождалась масштабных инвестиций, которые ей так необходимы для развития сети железных дорог России. Из глобальных мероприятий состоялось только обновление грузового вагонного парка и строительство инфраструктуры путей необщего пользования.Недостаток инвестиций привел к увеличению дефицита пропускных и провозных способностей сети и, как следствие, к неудовлетворенному спросу на перевозки. Динамичному росту объемов перевозок всегда соответствовало развитие сети железных дорог.Повышение весовых норм грузовых поездов является одним из приоритетных направлений, позволяющим увеличить резерв пропускной способности и провозную способность, а также повысить эффективность работы железных дорог в рыночных условиях.Цель – На полигоне ДВжд на всех направлениях к портам существует дефицит пропускной способности. В целях ускорения продвижения поездопотока к ним возникает необходимость рассмотрения всех возможных вариантов. В статье рассматриваются вопросы, связанные с возможностью пропуска соединенных поездов на двухпутных участках Дальневосточной железной дороги, как при постоянном их вождении, так и в условиях производства летних путевых работ.Метод или методология проведения работы: для решения задачи движения соединенных поездов используются графические и аналитические методы математического моделирования, научные методы сбора и обработки статистических данных, современные достижения в части общих принципов и методов управления рисками.Результаты: выявлены необходимые условия для обеспечения движения соединенных поездов.Область применения результатов: заключается в сравнении количества соединенных поездов своего формирования для участка и транзитных, которые поступают с Забайкальской железной дороги и участка Архара – Хабаровск II, выявлении преимущественных направлений следования таких поездов, а также положительных и отрицательных воздействий на такие показатели как средняя масса поезда и участковая скорость движения.
El edificio barroco de la iglesia de San Bernardo de Sevilla
Authors: Falcón Márquez Teodoro
Published: November 2020

En este artículo se analiza el proceso constructivo de la iglesia de San Bernardo de Sevilla, que marca la transición del barroco al neoclásico. Su edificación se llevó a cabo entre 1780 y 1785 bajo la dirección del arquitecto José Álvarez. Se publica la planta y sección longitudinal originales y comentamos los cambios de criterio experimentados con relación a ellos. Asimismo se documentan los materiales constructivos, así como los gastos de la construcción, además de los protagonistas que intervinieron en él, entre los que destaca el aparejador y arquitecto Fernando Rosales.
Santa María de Arcos de la Frontera y la sacristía de los cálices de la catedral de Sevilla: un viaje de ida y vuelta en la obra de Diego de Riaño
Authors: Ampliato Briones Antonio Luis , Rodríguez Estévez Juan Clemente
Published: November 2020

La iglesia de Santa María de Arcos de la Frontera es una obra del máximo interés en el conjunto del Tardogótico andaluz. La ambiciosa reforma emprendida en el siglo XVI, muy condicionada por una primitiva fábrica del XIV a cuyo esclarecimiento también contribuimos, se desarrolló entre 1519 y 1553 contando con una participación central y decisiva de Diego de Riaño, en el seno de cuya compleja trayectoria cobra pleno sentido. Más allá de su gran riqueza formal, su original concepción espacial, apenas explorada, nos descubre estrechas conexiones con la sacristía de los Cálices de la catedral de Sevilla, así como con la previa intervención de Juan del Castillo en la iglesia de los Jerónimos de Belém
La influencia neerlandesa en Las Meninas de Velázquez
Authors: Navarro Moragas Francisco Javier
Published: November 2020

Superado aquel aspecto nacionalista y diferenciador que la historiografía del siglo xix quiso destacar en la producción artística europea que le precedió, hoy escogemos comprender las mutuas interinfluencias que dieron origen a unas manifestaciones artísticas que fueron tejidas en el telar de una Europa compartida. Este trabajo apunta a considerar las influencias que la producción pictórica y el posicionamiento intelectual de los Países Bajos del Siglo de Oro ejercieron sobre la obra maestra de uno de los pintores más relevantes del siglo XVII europeo: Las Meninas, de Diego Rodríguez de Silva y Velázquez.
Sobre el copón de oro que se fabricó en “correspondencia con el gusto y belleza” de la urna de Valadier para el monumento del Jueves Santo de la catedral de Sevilla
Authors: Santos Márquez Antonio Joaquín
Published: November 2020

En este artículo se estudia una importante obra del tesoro de la catedral de Sevilla: el copón de oro y pedrería que se hizo para reservar al Santísimo Sacramento en la urna de oro labrada por Luigi Valadier.
El Santo Ángel Custodio de la iglesia de San Francisco: una nueva obra de Juan de Astorga en Tarifa (Cádiz). Pp.: 607
Authors: Cazalla Urbano Rafael
Published: November 2020

En el presente trabajo realizamos un análisis estilístico e iconográfico de la imagen del Santo Ángel Custodio que se venera en la iglesia parroquial de San Francisco de Asís de la localidad de Tarifa (Cádiz) y que consideramos obra personal del escultor archidonense Juan de Astorga (1779-1849).
María de los Ángeles López-Roberts en París: una artista de vanguardia en la ilustración Art Déco
Authors: Illán Martín Magdalena
Published: November 2020

En la década de 1930, la artista española María de los Ángeles López-Roberts (Madrid, 1902-1974) desarrolló una exitosa trayectoria como ilustradora en París. Destacada por la crítica gala por sus contribuciones a la renovación de la ilustración juvenil, en la que incorporó influencias de las vanguardias y de la estética Art Déco, este artículo analiza la intensa producción que la artista llevó a cabo como ilustradora durante el período en el que residió en la capital francesa.
Successful virtual UK Kidney Week sees record-breaking registration
Authors: Sewell Caitlin , Sheerin Neil , Cockwell Paul , Castle Ellen
Published: November 2020

The British Renal Society and Renal Association work together to deliver the annual UK Kidney Week conference. Caitlin Sewell, Neil Sheerin, Paul Cockwell and Ellen Castle report on the success of the first digital UKKW conference
COVID-19 and the UK lockdown: new challenges for the renal arts movement in Northern Ireland
Authors: Johnston William
Published: November 2020

The UK lockdown in March provided an opportunity for William Johnston, Northern Ireland Kidney Care UK Advocacy Officer, to further benefit from the renal arts in managing his wellbeing and health
Corneal Infection Associated with Diabetes: A Case Study & Literature Review
Authors: Miller S. , Pishgahi M. , Ghanim M. , Fongue S. , Alhasana O.H. , Najeemuddin S. , Lopez A.C. , Gunaseelan L. , Jamshaid A. , Charles P. , Hamid M.
Published: November 2020

A 54-year-old woman with a history of type 2 diabetes presented with concern for sudden eye pain, photophobia, and redness of the eye. History, physical examination and comprehensive lab tests, yielded a diagnosis of corneal keratopathy. She responded poorly to the initial management of moxifloxacin 5% and homatropine 2%. A multi-faceted approach involving strict glycemic control and antibiotic therapy was then adopted. Through dietary management and pharmacotherapy, the patient’s clinical disposition improved, highlighting the importance of glycemic control when managing diabetic keratopathy.
Analysis of the impact of optical aberrations in en-face full-field OCT microscopy
Authors: Blavier Marie , Glanc Marie , Rousset Gérard
Published: November 2020

Optical coherence tomography (OCT) is a powerful technique for cross-sectioning imaging. However, the lateral resolution may be degraded by optical aberrations originating from the sample or the setup. We present an extensive quantitative study of the impact of aberrations in time-domain en-face full-field OCT (FFOCT). Using an adaptive optics loop integrated in an FFOCT setup, a deformable mirror is used to introduce low-order calibrated aberrations. The experimental analysis of both the line spread functions (SF) and the complex object images has allowed us to measure the loss in contrast and the impact on lateral spatial resolution. We demonstrate that the frequency content of FFOCT image spectra in terms of signal-to-noise ratio and cutoff frequency is degraded by aberrations but remains much higher than in conventional incoherent images. Line SF profiles in conventional imaging display widening, whereas in FFOCT they display oscillations, leading to the possible perception of preserved resolution. Nevertheless, for complex objects, the aberration image blurring is strong due to the convolution process by the point SF, resulting in a significant filtering of the image spatial spectrum.
Az értékesítővé válás folyamata
Authors: Bauer András , Mitev Ariel Zoltán
Published: November 2020

A legtöbb vállalat törekszik arra, hogy az értékesítők képességeit és készségeit fejlessze, s ezért jelentős befektetésekre is hajlandó, képzés, támogatás és tréning formájában. Ugyanakkor az értékesítői szerep megértése és elfogadása is meghatározó a végső eredmény szempontjából. A szerzők cikkükben az értékesítővé válás folyamatát elemzik az értékesítők élménytöredékei alapján. E közelítés segítheti az eladási folyamatok irányítóit abban, hogy a szokásos mérőszámok helyett (vagy mellett) egy evolúciós gondolkodási keretet kínáljon a munkatársak fejlődésének követéséhez. Számos irodalom foglalkozik azzal, hogy mi jellemzi az értékesítők szocializálódásának folyamatát egyegy szervezettel kapcsolatosan, de azzal már kevésbé, hogy milyen tényezők határozzák meg a szakmaválasztást. Mennyire tudatos az értékesítési szakma választása vagy sokkal inkább a véletlennek köszönhető? A 400 fővel készült interjú alapján megállapítható, hogy az értékesítési szakmába kerülésnek több útja van, valamint az értékesítővé válás sokkal inkább tekinthető folyamatnak, mint egyszeri döntésnek. Az értékesítővé válás két szakaszra osztható (látens és manifeszt). A kérdéskört egy tágabb kontextusban kell értelmezni, hiszen az értékesítővé válás folyamata nem redukálható le egyetlen pillanatra. A választás ráadásul nem is mindig tudatosan történik, gyakran előfordul a véletlen szakmába kerülés, az odasodródás. A szerzők az interjúk során feltárt kirakós darabokat annak a folyamatnak mentén építették fel, ahol a külső és belső tényezők egyaránt megtalálhatók.
Több-módszertanú és vegyes módszertanú kutatások
Authors: Neulinger Ágnes
Published: November 2020

A marketingkutatás területét – más üzleti területekhez hasonlóan – markánsan érintik az elmúlt időszak társadalmi-gazdasági változásai. A kutatásmódszertan ennek megfelelően változik és ez a változás részben azt is jelenti, hogy a korábbi éles határok egyes módszertani területek között, úgymint a kvalitatív és kvantitatív megközelítések, elhalványulnak. Jelen tanulmány a több-módszertanú és vegyes módszertanú kutatásokat vizsgálja, illetve értelmezi ezeket az aktuális kutatás-módszertani trendek kapcsán.
Practice of Breast Self-Examination and Knowledge of Breast and Cervical Cancer Screening: A bi-national Survey in Africa
Authors: Omotoso Olabode , Matariek Ghadier , Omotoso Elizabeth , Matareek Amira , Abdul-Rafee Ghada Mahmoud , Malakar Sucheta , Chutia Nabanita
Published: November 2020

Background: The burden of breast and cervical cancer is increasing exponentially, especially among women in low- and mid-income countries due to late diagnosis, unhealthy lifestyle choices and adoption of western lifestyles. Early detection, hinged on screening uptake is a key to higher survival rate and managing cancer outcome. Despite some improvement noticed in developed countries, the control of these preventable diseases in African countries including Nigeria and Egypt seems insurmountable. Therefore, this study focused on assessing the knowledge and uptake of Nigerians and Egyptians towards breast self-examination (BSE) and breast and cervical cancer screening.

Results: A community-based cross-sectional questionnaire was utilized in both countries to obtain 1,006 respondents via a convenient sampling method. The mean age of study participants was 30.43 6.69. About one-third of participants had a good knowledge (> 66 %) of breast cancer screening (423, 42 %), cervical cancer screening (446, 44 %) and BSE practice (363, 36 %). Age range (26 40 years), educational level (tertiary) and marital status were demographic data that influenced knowledge level. Though with a fairly satisfactory knowledge level, the screening uptake among studied population is very poor as only (111, 11 %) had ever been screened and only (22, 2.2 %) ever vaccinated. The major reasons for poor screening uptake were no awareness of where to be screened and no symptoms.

Conclusions: Assessing the knowledge and uptake level of African women through studies like this is crucial in identifying the loopholes in the fight against cancer in Africa. More efforts are required in promoting utilization of cancer screening services, HPV vaccination and BSE practice among African women. The media and internet should be leveraged on as they are the major sources of information about cancer among the respondents.
Análisis multitemporal de asociaciones vegetales y cambios de uso del suelo en una localidad altoandina, Puno-Perú
Authors: Loza-Del-Carpio Alfredo , Taype-Huamán Irene
Published: November 2020

En los altos Andes se vienen evidenciando cambios no planificados de uso de territorios que conllevan a pérdida de áreas productivas y de importantes servicios ecosistémicos; documentando ese contexto, el objetivo de este estudio fue caracterizar los cambios temporales en la vegetación y uso del suelo en el distrito altoandino de Cabana (Perú). Se determinó el tipo de vegetación según la especie predominante en la cobertura; estas áreas, conjuntamente con las formas de uso de suelo frecuentes, se cuantificaron mediante análisis supervisado de imágenes Landsat con una resolución espectral de 30 m, obtenidas en los meses de marzo y abril de los años 2000, 2005, 2010 y 2016. Se identificaron seis tipos de asociaciones vegetales naturales cuyas áreas disminuyeron 2000 ha, de las 12 500 iniciales en 16 años (16,27 %); al año 2000 la asociación Muhlenbergetum fastigiatae tuvo la mayor cobertura (43,96 %), pero en 2016 predominó Calamagrostio vicunaro - Festucetum dolichophyllae (47,31 %). Las áreas de cultivo aumentaron desde 5133 ha (27 %) a 7115 ha (37 %) de la superficie distrital; se extendieron suelos degradados desde 35 a 120 ha, áreas con escasa vegetación de 17 a 30 ha y se redujeron humedales de 179 a 29,7 ha. La cobertura urbana crece a un 40,7 % anual. El aprovechamiento del suelo, sin base en un ordenamiento territorial, condujo al detrimento de la vegetación, y comprometió el aprovechamiento sostenible de recursos naturales.
MRI-targeted prostate biopsy: the next step forward!
Authors: Cata Emanuel Darius , Andras Iulia , Telecan Teodora , Tamas-Szora Atilla , Coman Radu-Tudor , Stanca Dan-Vasile , Coman Ioan , Crisan Nicolae
Published: November 2020

Aim. For decades, the gold standard technique for diagnosing prostate cancer was the 10 to 12 core systematic transrectal or transperineal biopsy, under ultrasound guidance. Over the past years, an increased rate of false negative results and detection of clinically insignificant prostate cancer has been noted, resulting into overdiagnosis and overtreatment. The purpose of the current study was to evaluate the changes in diagnosis and management of prostate cancer brought by MRI-targeted prostate biopsy.

Methods. A critical review of literature was carried out using the Medline database through a PubMed search, 37 studies meeting the inclusion criteria: prospective studies published in the past 8 years with at least 100 patients per study, which used multiparametric magnetic resonance imaging as guidance for targeted biopsies.

Results. In-Bore MRI targeted biopsy and Fusion targeted biopsy outperform standard systematic biopsy both in terms of overall and clinically significant prostate cancer detection, and ensure a lower detection rate of insignificant prostate cancer, with fewer cores needed. In-Bore MRI targeted biopsy performs better than Fusion biopsy especially in cases of apical lesions.

Conclusion. Targeted biopsy is an emerging and developing technique which offers the needed improvements in diagnosing clinically significant prostate cancer and lowers the incidence of insignificant ones, providing a more accurate selection of the patients for active surveillance and focal therapies.
A New Approach to Determining the Quality of Public Utilities
Authors:   V.M.Glushkov Institute of Cybernetics of NAS of Ukraine, Palagin Oleksandr V. , Bahatskyi Valentyn O. ,   V.M.Glushkov Institute of Cybernetics of NAS of Ukraine, Bahatskyi Oleksii V. ,   V.M.Glushkov Institute of Cybernetics of NAS of Ukraine
Published: November 2020

A unified approach is proposed for determining the quality of utilities, which allows you to determine both the quality of the utility and the quality of the services consumed by a particular consumer.
Ontology Application to Construct Inductive Modeling Tools with Intelligent Interface
Authors:   International Research and Training Centre of Information Technologies and Systems of the NAS and MES of Ukraine, Pidnebesna Halyna A. , Pavlov Andrii V. ,   International Research and Training Centre of Information Technologies and Systems of the NAS and MES of Ukraine, Stepashko Volodymyr S. ,   International Research and Training Centre of Information Technologies and Systems of the NAS and MES of Ukraine
Published: November 2020

This paper is devoted to the analysis of sources in the field of development and building intelligent user interfaces. Particular attention is paid to presenting an ontology-based approach to constructing the architecture of the interface, the tasks arising during the development, and ways for solving them. An example of the construction of the intelligent user interface is given for software tools of inductive modeling based on the detailed analysis of knowledge structures in this domain.
Treatment of inflammatory diseases of the pelvic organs, due to mixed infection
Authors:   SI Institute of Urology of the NAMS of Ukraine, Kyiv, Romashchenko O. V. , Vozianova S. V. ,   SI Institute of Urology of the NAMS of Ukraine, Kyiv, Rudenko A.V. ,   SI Institute of Urology of the NAMS of Ukraine, Kyiv, Yakovenko L.F. ,   SI Institute of Urology of the NAMS of Ukraine, Kyiv
Published: November 2020

Today the marked increase in the frequency of inflammatory diseases of the pelvic organs (IDPO) caused by sexually transmitted infections (STIs). And among the factors is dominated by numerous microbial associations (mixed infection) in 65-70% of cases detect Chlamydia, gonorrhea, Trichomonas, Molykote. The advantage of latent flow IDPO caused by these factors is one of the reasons for untimely and inadequate treatment of the inflammatory process of the genital organs and the formation of a range of violations of reproductive health of women. The aim of the study: the rationale for differentiated approaches to the treatment of chronic IDPO caused by mixed infection. Materials and methods. A survey of 72 women aged 18 to 37 years with IDPO with disease duration from 2 to 11 years. According to etiological factors and clinical course of HSTMT allocated groups were examined: First, the core group of 38 women with HSTMT caused by mixed infection in combination with Chlamydia, Molicutas; the SECOND main group - 34 patients with HSTMT caused by mixed infection in combination with Trichomonas. Results. Studies have shown that chronic inflammatory diseases of the genital organs in women are predominantly polietiologichesky nature; the latter determines the characteristics of the disease and its consequences. According to clinical and preclinical guidelines inflammatory diseases of the genital organs, caused by mixed infection, defined by differentiated approaches to the choice-stage anti-inflammatory therapy. Conclusion. Among the factors contributing to the effectiveness of treatment of inflammatory diseases of the genital organs, caused by mixed infection, should be highlighted: 1. Early diagnosis of the disease. 2. Identification and remediation of all sources of infection. 3. Compliance with phasing of conducting anti-inflammatory therapy. 4. The restoration of microbiocenosis of intestines, vagina, urethra with the use of the drug Laktovit Forte. 5. The correction of immunological disorders, the recovery of local immune defense. 6. Examination and the simultaneous treatment (if necessary) partner (partners). 7. Clinical, microbiological control of effectiveness of the treatment for 3 months; immunological control after 3, 6 months after treatment. Introduction to practical healthcare system of reasonable effective treatments for VSAT based on objective results of clinical and laboratory diagnostics, account etiological factors, state of systemic and local immunity, pathogenesis mechanisms of development of inflammatory process will contribute to the prevention of its chronicity and relapse. Key words: inflammatory diseases of the pelvic organs, mixed infection, treatment, Tiflox, Meratin.
The analysis of the efficiency of the program ІМSI at fertilization in vitro
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Kutsenko A.O.
Published: November 2020

The aim of the study: to analyze the results of the program ІМSI as one of the methods of VRT to ensure in vitro fertilization. Materials and methods. The basis of the study consisted of 100 couples with male factor infertility. Pair was examined and treated at the Institute of reproductive medicine (Kiev) in 2013-2015. The Diagnosis verified, assistance was provided in the framework of standard clinical protocols. The 51 men were diagnosed oligoasthenozoospermia, obstructive and non-obstructive azoospermia - in 28 and 21 men, respectively. Results. There were identified features according to the results of cycles. When native - biochemical pregnancy achieved almost equally often oligoasthenozoospermia and obstructive azoospermia (53.0±6.9% and 53.4±9.4%), whereas non-obstructive in two times less (28.6±9.8%). When critical the difference in results is not traced with obstructive and non-obstructive azoospermia and was 16% lower in cases of oligoasthenozoospermia. Biochemical pregnancies occurred in 63 of the 100 pairs (63.0±4.8%), with oligoasthenozoospermia and 37 of 51 (72.5 per cent), obstructive azoospermia – in 19 of 28 (67.8 per cent), non-obstructive – 7 of 21 (33.3 percent). After reproductive losses (5 of 63, 7.9% as) the end result was lower – 58.0±4.9 per cent. The number of births in total in the group with oligoasthenozoospermia was 35 of 51 (68.6%), obstructive and non-obstructive azoospermia - 17 of 28 (60.7 per cent) and 6 of 21 (28.6 per cent), respectively. Conclusion. The data motivate the need of finding opportunities to improve program performance ІМSI. Promising in this regard is the preparation of the pair to her conduct, which goes beyond the limits of the medical, carried out according to the protocols. An important point should be the identification and leveling of risk factors for general medicine and a social plan. Key words: male infertility, the program ІМSI, results.
Reasoning of medical tactics at the preconception in patients with a history of miscarriage and abnormal vaginal discharge
Authors:   Danylo Halytskyy Lviv National Medical University, Lviv, Ukraine, Schuruk N.V. , Pyrohova V.I. ,   Danylo Halytskyy Lviv National Medical University, Lviv, Ukraine
Published: November 2020

The objective: evaluating the effectiveness and safety of the drug complex hinekit during preconception preparation for women with complicated pregnancy loss history and uncomplicated mixed genital infections. Patients and methods. The study involved 65 women with reproductive losses in history, who turned over the abnormal vaginal discharge. Diagnosis of sexual transmitted infections (C. trachomatis, T. vaginalis, HSV-II, HPV), assessment of vaginal microbiota was performed by PCR with detection results in real time. Bacterial Vaginosis verified by the Amsel system. Results. All the examinees in the history have miscarriage in the first (56.9%) or the second (43.1%) trimester of pregnancy. According to the results of the patient survey were divided into clinical groups. In 26.2% of women infectious pathology of the lower genital tract has not been confirmed, 26.2% of patients did not give consent to participate in the study and were formed in the control group that received therapy according to existing clinical settings. 31 patients with mixed genital infection (study group) received complex preparation gіnekit. This positive trend was observed in all the patients of the main group (the disappearance of subjective sensations on average 2.2±0.3 hours). After treatment T. vaginalis, BV were not detected in one patient, active mycotic process in the absence of complaints remained at 4.8% of women, complete eradication of C. trachomatis was achieved in 92.3% of patients. Conclusions. Reducing the duration of treatment of mixed genital infections at the preconception in women with reproductive losses in the history is achieved in terms of clinical, microbiological and pharmaco-economic benefits by prescribtion an gіnekit preparation. Summary of clinical and microbiological effects of the proposed approach is 96.0 ± 0.9%, which corresponds to all requirements for multimodal therapy of genital infections, and no side effects, short course of treatment provides a high compliance of patients (9.2±0.7 points). Key words: mixed genital infections, miscarriages, gіnekit, azithromycin, fluconazole, seknidazol.
Results of using the domestic synbiotic Bifiten for treatment of bacterial vaginosis of pregnant women
Authors:   SHEI Uzhgorod national University, Ukraine, Tsmur O. , Levchuk O. ,   SHEI Uzhgorod national University, Ukraine, Liashyna K. ,   SHEI Uzhgorod national University, Ukraine, Boyko N. ,   SHEI Uzhgorod national University, Ukraine
Published: November 2020

The article shows the research results of vaginal microbiome correction of pregnant women with bacterial vaginosis before and after oral using of synbiotic Bifiten. This biopreparation differs from others recommended for vaginal microbiome correction by its combined anti-inflammatory and specific pro- and antimicrobial activity. The aim of research is to define the clinical efficacy of oral administration of the non-medicinal biological (synbiotic) preparation Bifiten to pregnant women with bacterial vaginosis. Materials and Methods. Clinical and statistical analysis of pregnant women's individual cards, childbirth stories had been held. Vaginal microbiome had been studied by using classic microbiological methods and qRT-PCR. Immune parameters of vagina secrets had been detected by immunosorbent assay (ELISA). Results. A positive dynamics of subjective and objective state of pregnant women had been observed. It was shown that following to the oral administration of Bifiten mucous membranes of vagina were settled by both commensal and transit microbiota, which in turn leads to reduction the perinatal complications for the mother and newborn. The effectiveness of the application of Bifiten against agents of gardnerellez and candidiasis is clinically proved. Conclusion. Feasibility of using synbiotic Bifiten to treat pregnant women with bacterial vaginosis had been clinically proved. Good tolerability, complementarity or alternative taking with antibiotic therapy, no side effects, convenient form of release make reasonable to recommend it for the gynecology for the effective treatment of pregnant women with bacterial vaginosis. Key words: bacterial vaginoses, vagina microbiome, synbiotic, aerobic and anaerobic pathogens, commensals, cytokines.
Colposcopical, cytological parallels in pregnant women with large intervals interhenetyc
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kyiv, Ukraine, Tumanova L.E. , Kolomiets Е.V. ,   SI Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kyiv, Ukraine, Badzyuk N.P. ,   SI Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kyiv, Ukraine
Published: November 2020

Relevance of the study of cervical pathology in pregnant women due not only to high frequency, the development of socially active women age and the ability to transition to the malignant form, but ineffective existing methods of diagnosis and treatment The objective: To investigate cytological, colposcopic features of cervical cancer in pregnant women with great interhenetyc interval. Patients and methods. We examined 81 women 40 women with great intergenetichnim intervals in the course of pregnancy, childbirth and the postpartum period – Group 1; 27 pregnant women who gave birth for the first time at the age of 30 years, 2-nd group, 14 pregnant women who have a break between the first and subsequent births was 3-5 years old – Group 3. The study of the cervix uteri of pregnant women with large intergenetic intervals in later stages performed by colposcopic and cytological methods. Statistical processing osuschstvlyali standard methods. Results. The data show elevated levels of precancerous cervical pathology in pregnant women with great interhenetyc intervals and in the age of pregnant women compared to young pregnant women in which the interval between births is small – 3–5 years. A small percentage difference precancerous lesions of the cervix, 22.5% – women in group 1 and 22.2% – women in group 2, but said that with increasing age probability themselves elimination papillomavirus is reduced accordingly increases the risk of precancer and cervical cancer. Conclusion. 1. The study showed that the problem of the status of the cervix in women with large intergenetic interval remains relevant and not studied until the end. 2. Pregnant women for the first time after 35 years and with more multiparous intergenetichnim interval must always be at the first visit to the antenatal clinic in addition to taking a Pap smear colposcopic spending review. 3. In case of LSIL and HSIL in this category of women – colposcopic and cytological control 1 every 3 months during pregnancy with mandatory HPV PCR WRC. Key words: cervical pathology, pregnancy, colposcopy, cytology.
Clinical and pathogenetic substantiation of prevention of obstetrical complications in pregnant women with varicose disease
Authors:   SI Lugansk State Medical University, Rubizhne, Ukraine, Korniets N.G. , Kravtsova Y.A. ,   SI Lugansk State Medical University, Rubizhne, Ukraine
Published: November 2020

The article presents the results of an improved method of antenatal surveillance of pregnant women with varicose disease which included the national medical drug that is a combination of 50 mg hesperidin and 450 mg diosmin (Normoven, PC «Kyiv Vitamin Factory»). Patients and methods. The study involved 49 pregnant women with varicose veins, which were divided into the basic and comparative group depending on the received treatment. The clinical and functional parameters, laboratory and instrumental methods were studied. The control group consisted of 23 pregnant women without varicose veins. Results. The absence of progression of clinical symptoms of the disease in 87.5% of pregnant women with varicose veins and improvement of the hemostatic parameters reflects the effectiveness of this therapy for the correction of the rheological properties of blood. The inclusion of hesperidin and diosmin to the complex therapy in pregnant women allowed to decrease the percentage of progression of changes in the venous system of the lower extremities almost twice. The normalization of processes of biosynthesis placental hormones in pregnant women shows the feasibility of using the drug with the systemic effects. The increase of the amplitude of instantaneous oscillations and the amplitude and duration of accelerations (p<0.05) according to the cardiotocographical observation indicates in favor of improving the state of the fetus in pregnant women. Conclusions. The inclusion of diosmin and hesperidin to the complex treatment of varicose veins in pregnant women is pathogenetically justified as it improves the degree of clinical manifestations of disease, hemostatic parameters , hormonal function of the placenta and fetus state. Key words: pregnancy, varicose veins, placental hormones, hemostatic parameters, hesperidin, diosmin.
Vascular surgery and an occurrence of stroke
Authors:   Department of Anatomy, Medical College of Rzeszów University, Rzeszów, Poland, Leksa Natalia , Uryniak Adam ,   Rzeszów Center for Vascular and Endovascular Surgery, Rzeszow, Poland, Aebisher David ,   Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland, Leksa David ,   Rzeszów Center for Vascular and Endovascular Surgery, Rzeszow, Poland, Bartusik-Aebisher Dorota ,   Department of Biochemistry and General Chemistry Medical College of Rzeszów University, Rzeszów, Poland
Published: November 2020

Introduction. The brain responds to metabolic disorders with a limited array of symptoms and signs. The brain has enormous needs in terms of substrate and blood flow. Aim. This paper presents a case report reporting episode of stroke. Description of the case. The incidence of cerebral vascular episodes in the form of strokes, transient episodes of cerebral ischemia is reported. Conclusion. The chemical constituency of the brain are generally quite different from those of other tissues. Stroke is a clinical syndrome characterized by sudden focal or generalized brain dysfunction.
Bladder leiomyoma: diagnostics, laparoscopy, and treatment
Authors:   Clinical Department of Urology and Oncological Urology Clinical Provincial Hospital No.1, Rzeszów, Poland, Godlewski Dominik , Pszczółkowski Patryk ,   Clinical Department of Urology and Oncological Urology Clinical Provincial Hospital No.1, Rzeszów, Poland, Fedus Tadeusz ,   Clinical Department of Urology and Oncological Urology Clinical Provincial Hospital No.1, Rzeszów, Poland, Aebisher David ,   Department of Photomedicine and Physical Chemistry, Medical College of Rzeszów University, Rzeszów, Poland
Published: November 2020

Introduction. Leiomyosarcoma is the most common benign tumor of the bladder. However, it is only a small percentage of all proliferative changes of this organ. Aim. Presentation based on two clinical cases of diagnostics and surgical treatment from laparoscopic access of bladder leiomyoma. Description of the cases. Case 1. The work contains a diagnosis based on transvaginal ultrasound (TVUS), cystoscopy and computed tomography (CT), as well as partial laparoscopic bladder re section of leiomyoma in young women. Case 2. The case of young women with the histopathological result confirmed bladder leiomyoma. Conclusions. Leiomyoma is a rare bladder cancer. Laparoscopic bladder resection is a safe method that leads to healing.
The Impact of ‘Stay At Home’ Orders on Emergency Room Admissions
Authors:   Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey, Kocak Abdullah Osman , Dogruyol Sinem ,   Department of Emergency Medicine, Manisa Merkez Efendi State Hospital, Manisa, Turkey, Akbas Ilker ,   Department of Emergency Medicine, Bingol State Hospital, Bingol, Turkey, Kerget Bugra ,   Department of Pulmonary Diseases, Faculty of Medicine, Ataturk University, Erzurum, Turkey, Akgol Gur Sultan Tuna ,   Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey, Cakir Zeynep ,   Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey
Published: November 2020

Introduction. The 2019-novel-coronavirus (2019-nCoV) outbreak has become a common problem for the whole world. Aim. To investigate the impact of the 2019-nCoV pandemic period in our country on emergency room admissions. Materials and methods. The study was designed as a retrospective cohort. The first case of pneumonia infected with nCoV in our country was diagnosed on March 11, 2020. Considering the date of March 11, 2020, emergency room admissions for two periods of 7 days were investigated, pre-COVID-19 and COVID19. Demographic data, admission diagnosis, vital findings, stay times in emergency room, terminations and emergency department mortality examined. A group of ‘geriatric’ patient populations were created to examine the admission characteristics of patients aged-65 and over. Results. The 3466 patients included in the study. The average number of daily admissions was significantly higher in the pre-COVID-19 period (350.4 ± 54.5), compared to the COVID-19 period (144.7 ± 20.2, p=0001). While the proportion of cardiac- caused admissions increased during the COVID period, the proportion of gastrointestinal-induced admissions decreased (p<0001). Hospitalization rates for both adult and geriatric patients increased during the COVID period (p<0001). Conclusion. Despite all the negativity caused by the outbreak, this period has been one in which the public is aware of unnecessary emergency room which has been subsequently lessened.
Seroprevalence of Toxoplasmosis among Human Immunodeficiency Virus infected pregnant women in Abuja Teaching Hospital, Nigeria
Authors:   Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria, Zakari Maryam Muhammad , Isah Aliyu Yabagi ,   Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria, Offiong Richards ,   Department of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria, Yunusa Thairu ,   Department of Medical Microbiology and Parasitology, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria, Abdullahi Idris Nasir ,   Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria
Published: November 2020

Introduction. Toxoplasmosis is a neglected parasitic infection that has economic and epidemiological significance. Data on toxoplasmosis seroprevalence among Human Immunodeficiency Virus (HIV) infected pregnant women may be of obstetric and neonatal concern. Aim. The study was designed to determine the seroprevalence of Toxoplasmosis and associated risk factors in HIV-positive pregnant women attending the University of Abuja Teaching Hospital, Abuja, Northcentral Nigeria. Material and methods. This was a hospital-based cross-sectional study. A total of 160 HIV seropositive pregnant women were recruited. Blood samples were collected and tested for anti-T. gondii IgM and IgG using Enzyme Linked Immunosorbent Assay (ELISA). Structured questionnaires were used to collate the sociodemographic variables of participants. Results. Out of the 160 of HIV seropositive pregnant women, the seroprevalence anti-T. gondii IgG and IgM were 29.4% and 4.4%, respectively. There was no significant association between anti-T. gondii and all sociodemographic variables studied (p>0.05). Conclusion. The overall result of this study revealed that the majority of pregnant women were exposed to toxoplasmosis much earlier in life. Hence, these findings will assist obstetricians and gynecologists in the early diagnosis and management of Toxoplasma gondii infection in pregnant women, especially HIV coinfected ones with IgM seropositivity.
Cognitive behavioural therapy and core stabilization exercise on pain-related disability and psychological status in patients with non-specific chronic low back pain
Authors:   Department of Physiotherapy, College of Medicine, University of Lagos, Yaba, Lagos, Nigeria Clinical Trial Registry number: PACTR201910791448143, Akodu Ashiyat Kehinde , Ogunbiyi Thompson Adewale ,   Department of Physiotherapy, College of Medicine, University of Lagos, Yaba, Lagos, Nigeria Clinical Trial Registry number: PACTR201910791448143, Fapojuwo Oluwaseun Akinleye ,   Department of Physiotherapy, College of Medicine, University of Lagos, Yaba, Lagos, Nigeria Clinical Trial Registry number: PACTR201910791448143
Published: November 2020

Introduction. Exercises have been shown to relieve symptoms in non-specific chronic low back pain (NSCLBP) patients. Aim. This study compared the effects of cognitive behavioural therapy (CBT) and core stabilization exercises (CSE) on pain-related disability, psychological status and sleep disturbance in patients with NSCLBP. Material and methods. This randomized controlled trial involved a total of thirty-seven (37) participants. They were randomly allotted into three groups [CBT (11), CSE (14) and control (12)]. The intervention was done once per week for duration of 60 minutes for the CBT group, 30 minutes for CSE group and 10 minutes for the control group twice per week for 8 consecutive weeks. Assessment of outcome was done at baseline, 4 weeks and 8 weeks. Data were analyzed using statistical package for social science version 25 at alpha level of less than 0.05. Results. The results of this study showed that there was significant improvement in the level of pain-related disability (p= 0.001), level of anxiety (p =0.001), depression (p = 0.01, p = 0.001, p =0.001) and sleep disturbance (p = 0.001) in all the groups (CBT, CSE, control) post treatment. Conclusion. CBT and CSE are both effective in the treatment of pain-related disability, sleep disturbance, and psychological status of NSCLBP patients.