bluuebunny/crossref_metadata_2025 huggingface dataset:
Technological Developments as a New Challenge for Modern Legislation
Authors: Monika Wyszomirska
Published: December 2023

Aim: The aim of the article is to present the legal aspects of the use of new technologies. Accelerating the progress of civilization through the rapid development of technology is a challenge for both the legislator and entities who, when applying the law, interpret imperfect regulations or have to deal with the lack of regulations on a daily basis. In this publication, the author discusses legal aspects related to the development and implementation of new technologies and answers the question whether the applicable regulations combine the intentions of the creators of the regulations with social and economic needs. Introduction: The essence of all development is the improvement and expansion of human and technological capabilities and potential. Civilizational development is a system of interconnected vessels based on mutual social, cultural and technological interdependencies, and all these spheres of public life are inextricably linked with legal regulations. Without elementary knowledge of regulations, it would be difficult to make rational decisions regarding everyday life, therefore legal standards should include solutions adequate to the needs of citizens and the economy. In case of new technologies, which are subject to continuous and dynamic changes, the traditional norm-setting model known as hard law does not fully achieve its goals, and what is more, the applicable law does not keep up with the development of new technologies. Methodology: he article describes the current state of knowledge in the field of selected aspects of new technology law. The work uses theoretical research methods, including the analysis of applicable regulations and the literature and views of the doctrine, as well as the results of the research work of the author of the publication. Conclusions: Current legal regulations do not keep up with new technologies. The legislative process itself is complicated and very long. The introduction of new regulations and legislative changes requires, among others, inter-ministerial and social arrangements, work in Sejm and Senate committees, voting in Parliament, and finally the signature of the President of the Republic of Poland. The above-mentioned legal activities take time, and new technologies mean variability and dynamism – a constant fight against time. The development of technology is certainly a new challenge for legislators, for whom cooperation with the scientific community and representatives of various technological industries is an opportunity to create regulations that support rather than limit the development of 21st century technologies. Keywords: law of new technologies, technological revolution, security, implementation of innovations
Developer in Law №5655
Authors: Sarkisian L.
Published: December 2023

In order to clarify the logic and motives of the initiators of Law 5655, a systematization of factors affecting the effectiveness of construction business projects was carried out. The norms of the law 5655 were revealed, for the creation of: a system of qualification of engineers, private authorized persons of urban planning control, the urban planning chamber for their punishment, under the control of large developers to receive infrastructure rent. The negative impact of Law 5655 on the level of: competition, transaction costs, investment risks, innovations in construction and sustainable development of communities is substantiated.
Multi-kernel driven 3D convolutional neural network for automated detection of lung nodules in chest CT scans
Authors: Wu Ruoyu , Liang Changyu , Zhang Jiuquan , Tan QiJuan , Huang Hong
Published: December 2023

The accurate position detection of lung nodules is crucial in early chest computed tomography (CT)-based lung cancer screening, which helps to improve the survival rate of patients. Deep learning methodologies have shown impressive feature extraction ability in the CT image analysis task, but it is still a challenge to develop a robust nodule detection model due to the salient morphological heterogeneity of nodules and complex surrounding environment. In this study, a multi-kernel driven 3D convolutional neural network (MK-3DCNN) is proposed for computerized nodule detection in CT scans. In the MK-3DCNN, a residual learning-based encoder-decoder architecture is introduced to employ the multi-layer features of the deep model. Considering the various nodule sizes and shapes, a multi-kernel joint learning block is developed to capture 3D multi-scale spatial information of nodule CT images, and this is conducive to improving nodule detection performance. Furthermore, a multi-mode mixed pooling strategy is designed to replace the conventional single-mode pooling manner, and it reasonably integrates the max pooling, average pooling, and center cropping pooling operations to obtain more comprehensive nodule descriptions from complicated CT images. Experimental results on the public dataset LUNA16 illustrate that the proposed MK-3DCNN method achieves more competitive nodule detection performance compared to some state-of-the-art algorithms. The results on our constructed clinical dataset CQUCH-LND indicate that the MK-3DCNN has a good prospect in clinical practice.
High-resolution iterative reconstruction at extremely low sampling rate for Fourier single-pixel imaging via diffusion model
Authors: Song Xianlin , Liu Xuan , Luo Zhouxu , Dong Jiaqing , Zhong Wenhua , Wang Guijun , He Binzhong , Li Zilong , Liu Qiegen
Published: December 2023

The trade-off between imaging efficiency and imaging quality has always been encountered by Fourier single-pixel imaging (FSPI). To achieve high-resolution imaging, the increase in the number of measurements is necessitated, resulting in a reduction of imaging efficiency. Here, a novel high-quality reconstruction method for FSPI imaging via diffusion model was proposed. A score-based diffusion model is designed to learn prior information of the data distribution. The real-sampled low-frequency Fourier spectrum of the target is employed as a consistency term to iteratively constrain the model in conjunction with the learned prior information, achieving high-resolution reconstruction at extremely low sampling rates. The performance of the proposed method is evaluated by simulations and experiments. The results show that the proposed method has achieved superior quality compared with the traditional FSPI method and the U-Net method. Especially at the extremely low sampling rate (e.g., 1%), an approximately 241% improvement in edge intensity-based score was achieved by the proposed method for the coin experiment, compared with the traditional FSPI method. The method has the potential to achieve high-resolution imaging without compromising imaging speed, which will further expanding the application scope of FSPI in practical scenarios.
Terahertz broadband tunable multifunctional metasurface based on VO2
Authors: Zhuang Lingyun , Zhang Wenjing , Chao Minghao , Liu Qingsong , Cheng Bo , Song Guofeng , Liu Jietao
Published: December 2023

A switchable multi-function terahertz metasurface employing phase
transition material vanadium dioxide (VO2) is presented and
investigated. By varying the temperature, the hybrid structure can
switch between transmission, absorption, and reflection modes in
broadband ranges. When the temperature is below 340 K and
VO2 is in the insulating state, perfect polarization
conversion is demonstrated. Efficient asymmetric transmission (AT)
exceeding 0.7 is simultaneously achieved with an ultra-wide bandwidth
of 3.6THz. When VO2 is in the metal phase, it shows
different modulation characteristics for x and y-polarized waves. The
structure can absorb over 90% of y-polarized waves from 3.56
THz to 7.2 THz (bandwidth, 3.64 THz), while 85% of x-polarized
waves are reflected from 1 THz to 9 THz (bandwidth, 8 THz). Compared
with other related published works, the designed structure makes
significant progress in integrated functionalities, operating
bandwidth, and working efficiency. It shows great potential for use in
terahertz dynamic control and multifunctional integrated systems.
Beyond Synthetic Aperture Focusing: Deconvolution-Based Elevation Resolution Enhancement Using Simulated Point Spread Function for Linear Array-Based Three-dimensional Photoacoustic Imaging
Authors: Tang Yichuan , Lesniak Wojciech , Gao Shang , Wu Yixuan , Zhang Haichong , Pomper Martin
Published: December 2023

This paper introduces a deconvolution-based method to enhance the elevation resolution of a linear array-based three-dimensional (3D) photoacoustic (PA) imaging system. PA imaging combines the high contrast of optical imaging and the high spatial resolution in multi-centimeter imaging depth of ultrasound (US) imaging, providing both structural and functional information of biological tissues. Linear array-based 3D PA imaging is easily accessible and applicable for ex vivo, small animal, and human subjects. However, the elevation resolution is limited due to the single elevation focus set by the acoustic lens geometry. Previous work used synthetic aperture focusing (SAF) to enhance elevation resolution, but the achievable resolution is constrained by the effective aperture size, which is significantly narrower than that in the lateral axis. Here, we propose using Richardson-Lucy deconvolution, based on simulated point-spread-functions, to enhance elevation resolution beyond SAF images. The method was validated using both simulation and experimental data. Results show that the full-width-at-half-maximum of point targets on the elevation plane was reduced compared to using SAF only, suggesting resolution improvement. The proposed method demonstrates the potential to improve 3D image quality of existing linear array-based PA imaging systems, thus benefiting disease diagnostics and follow-up evaluations.
Five-year serological and clinical evolution of chronic Chagas disease patients in Cochabamba, Bolivia
Authors: Pinto Jimy , Skjefte Malia , Alonso-Padilla Julio , Lozano Beltran Daniel Franz , Pinto Lilian Victoria , Casellas Aina , Arteaga Terrazas Mery Elena , Toledo Galindo Karen Alejandra , Challapa Quechover Roxana , Escobar Caballero María , Perez Salinas Alejandra , Castellón Jimenez Mario , Sanz Sergi , Gascón Joaquim , Torrico Faustino , Pinazo María Jesús
Published: December 2023

Background

Chagas disease, caused by the parasite Trypanosoma cruzi, is a neglected infectious disease that exerts the highest public health burden in the Americas. There are two anti-parasitic drugs approved for its treatment–benznidazole and nifurtimox—but the absence of biomarkers to early assess treatment efficacy hinders patients´ follow-up.

Methodology/Principal findings

We conducted a longitudinal, observational study among a cohort of 106 chronically T. cruzi-infected patients in Cochabamba (Bolivia) who completed the recommended treatment of benznidazole. Participants were followed-up for five years, in which we collected clinical and serological data, including yearly electrocardiograms and optical density readouts from two ELISAs (total and recombinant antigens). Descriptive and statistical analyses were performed to understand trends in data, as well as the relationship between clinical symptoms and serological evolution after treatment. Our results showed that both ELISAs documented average declines up to year three and slight inclines for the following two years. The recorded clinical parameters indicated that most patients did not have any significant changes to their cardiac or digestive symptoms after treatment, at least in the timeframe under investigation, while a small percentage demonstrated either a regression or progression in symptoms. Only one participant met the “cure criterion” of a negative serological readout for both ELISAs by the final year.

Conclusions/Significance

The study confirms that follow-up of benznidazole-treated T. cruzi-infected patients should be longer than five years to determine, with current tools, if they are cured. In terms of serological evolution, the single use of a total antigen ELISA might be a more reliable measure and suffice to address infection status, at least in the region of Bolivia where the study was done. Additional work is needed to develop a test-of-cure for an early assessment of drugs´ efficacy with the aim of improving case management protocols.
Simulation and analysis of hydraulic transition process based on mechanical hydraulics
Authors: Chen Chaoyu , Zhan Qingbiao
Published: December 2023

With the scarcity of water resources in various regions, the pressure on water supply projects is also increasing, which has led to a sharp increase in the water hammer effect in water supply pump projects. In response to this issue, the study proposes to apply a unidirectional pressure regulating tower based on mechanical hydraulic technology to water hammer protection in water supply pumps. In addition, the study also optimizes the calculation method of water hammer and designs one simulation software, which is used to simulate and analyze the proposed water hammer protection measures. The study first determines through simulation software that the optimal initial water level of the unidirectional pressure regulating tower is 2m and the optimal diameter of the make-up water pipe is 600 mm. Afterwards, simulation analysis is conducted on different water hammer protection measures, and it is found that the maximum pressure of the water hammer under the proposed protection measures is the lowest, at 14.8m, which was lower than the comparison measures. In addition, according to expert ratings, the average protective effect rating of protective measure 1 by relevant technical personnel is 9.4 points, which is better than the comparative measure. The above results indicate that through the simulation analysis of hydraulic transition process based on mechanical hydraulics, it can be found that the water hammer protection measures proposed in the study have good protective functions and can effectively reduce the water hammer effect in water supply engineering.
Functional expression and ligand identification of homo- and heteromeric Drosophila melanogaster CO2 receptors in the Xenopus laevis oocyte system
Authors: Ziemba Paul M. , Mueck Alina , Gisselmann Günter , Stoertkuhl Klemens F.
Published: December 2023

Carbon dioxide (CO2) is an important olfactory cue in Drosophila melanogaster and can elicit both attractive and aversive behaviors. It is detected by gustatory receptors, Gr21a and Gr63a, found in the ab1C neuron in basiconic sensilla on the third antennal segment. Volatile substances that modulate the receptors’ function are of interest for pest control. While several substances block ab1C neurons or mimic the activating effect of carbon dioxide, it is not known if these substances are indeed ligands of the CO2 receptor or might act on other proteins in the receptor neuron. In this study, we used the recombinant Xenopus laevis expression system and two-electrode voltage-clamp technology to investigate the receptor function. We found that application of sodium bicarbonate evokes large inward currents in oocytes co-expressing Gr21a and Gr63a. The receptors most likely form hetromultimeric complexes. Homomultimeric receptors of Gr21a or Gr63a are sufficient for receptor functionality, although oocytes gave significantly lower current responses compared to the probable heteromultimeric receptor. We screened for putative blockers of the sodium bicarbonate response and confirmed that some of the substances identified by spike recordings of olfactory receptor neurons, such as 1-hexanol, are also blockers in the Xenopus oocyte system. We also identified a new blocking substance, citronellol, which is related to insect repellents. Many substances that activate receptor neurons were inactive in the Xenopus oocyte system, indicating that they may not be ligands for the receptor, but may act on other proteins. However, methyl pyruvate and n-hexylamine were found to be activators of the recombinant Gr21a/Gr63a receptor.
Number and ratio of metastatic lymph nodes impacts the prognosis of submandibular gland cancer
Authors: Fang Qigen , Dai Liyuan , Zhang Xu , Luo Ruihua , Yuan Junhui
Published: December 2023

This study aimed to assess the impact of the number and ratio of metastatic lymph nodes (LNs) on prognosis in submandibular gland cancer. To this end, patients were selected from the Surveillance, Epidemiology, and End Results database retrospectively. The effect of the number and ratio of metastatic LNs and the American Joint Committee on Cancer (AJCC) N stage on disease-specific survival (DSS) and overall survival (OS) was analyzed. In addition, prognostic models based on LN evaluation methods were developed to predict the OS and DSS. A total of 914 patients were included. Binary recursive partitioning analysis determined the optimal cut-off number of metastatic LNs (0 vs. 1–2. vs. 3+). The presence of 3+ metastatic LNs carried the greatest impact on prognosis, followed by 1–2 positive LNs occurrences. The ratio of metastatic LNs was an independent factor for DSS and OS. The model had a higher likelihood ratio and C-index than those in the Cox model based on the AJCC N stage. Quantitative LN burden and ratio of metastatic LNs provides better survival stratification than the AJCC N stage.
DISPROPORTIONS IN THE DEVELOPMENT OF THE NATIONAL REPUBLICS OF RUSSIA IN THE ASSESSMENTS OF RUSSIAN SOCIOLOGISTS: THE ETHNOSOCIAL ASPECT (USING THE EXAMPLE OF ASIAN RUSSIA)
Authors: Erokhina Elena A.
Published: December 2023

The article is devoted to the problem of disproportion in the regional development of the national republics of Asian Russia: the Republic of Altai, the Republic of Buryatia, the Republic of Sakha (Yakutia), the Republic of Tyva, the Republic of Khakassia. The problems of demographic development of regions (decrease in average life expectancy and the share of the population, including Russian, “Western” migration trend), quality of life (decrease in income and employment), development of industry and agriculture are considered. The empirical basis of the study was a comparative analysis of indicators of average life expectancy at birth, average per capita income, employment and unemployment levels based on Rosstat data. The results of research by Russian sociologists studying these regions were used as secondary sources of information. A serious lag in the quality of life of the national regions of the Siberian and Far Eastern districts from the Russian average has been revealed. The conclusion is made about the need to overcome the view of Asian Russia as an exclusively resource storehouse.
MULTIDIMENSIONAL APPROACH TO EVALUATION OF POPULATION RELIGIOSITY IN RUSSIA'S ASIAN BORDERLANDS
Authors: Maximova Svetlana G. , Noyanzina Oksana E. , Omelchenko Daria A.
Published: December 2023

The article is focused on an analysis of sociological methods of evaluation of religiosity in the context of current transformations of religious consciousness and worldview, the blurring of boundaries between the secular and the religious, and the prevalence of hybrid variants of religious identity, which imply religiosity "beyond confession" and passive religious practices. The authors defend the vision of religiosity as a multidimensional construct that combines objective and subjective, static and dynamic, internal and external characteristics and manifestations. The authors present the results of sociological studies of the population's religiosity in four border regions of Russia - Altai Krai, Novosibirsk Oblast, Republic of Altai, and Republic of Tyva (n = 400 in each region). The Centrality CRS index (Centrality CRS Sh. Huber) is used as the main tool for analyzing religiosity, which allows for an assessment on five dimensions (levels) - cognitions (information), belief (ideology), personal and public practices and religious experience, taking into account the polyconfessional nature of regional societies. The objectives of the study were to compare the results obtained on the national sample with the results in the conditions of the border region and its separate regions characterized by ethno-confessional uniqueness, to analyze the individual dimensions of religiosity and their interrelation with the general index on the basis of factor analysis. It is shown that the index has good psychometric properties, and its individual dimensions are well described by a single-factor structure. The level of religiosity in all four regions generally corresponds to the all-Russian level, while there are serious differences between the regions, caused not only by the axis - national (ethnic) regions - multi-ethnic regions with a dominant Russian and Orthodox population, but also by individual dimensions.
FACTORS OF PROFESSIONAL BURNOUT OF TEACHERS AS A SYSTEM MANAGEMENT PROBLEM IN THE SPHERE OF EDUCATION
Authors: Stol Anna V.
Published: December 2023

The article examines the factors of professional burnout of teachers in Russia and Bashkortostan, including on the basis of a survey conducted by the working group of the Institute for Strategic Studies of the Academy of Sciences of the Republic of Belarus to discuss the optimization of the load on teachers of general education organizations at the Parliamentary hearings of the State Assembly - Kurultai of the Republic of Bashkortostan. Burnout factors are considered: features of the teaching profession, uncontrollable and increased workload, quality of feedback (support from the administration, relations with parents), lack of clarity of roles (changes in requirements) and freedom in decision-making, work experience, age, gender factor. It is concluded the problem of professional burnout is associated with the management system in the field of education, the level of wages, non-standardized and uncontrolled workload, lack of prevention and timely assistance, as well as, to a small extent, the gender factor. This means that the solution of the issue should be systemic and complex.
ASSESSMENT OF THE LEVEL OF DIGITAL MATURITY OF THE SPHERE OF CULTURE: CLASSIFICATION OF REGIONS OF RUSSIA
Authors: Kondakova Natalia A. , Gruzdeva Mariya A.
Published: December 2023

The purpose of the article is to analyze the features and trends in the development of digital infrastructure in the cultural sector, as well as assess the level of digital maturity in this area in the regions. The data was analyzed and the dynamics of digital processes in the field of culture for 2013-2021 were determined for 80 constituent entities of the Russian Federation. Using indicators of the share of public libraries with Internet access; museums that have a website on the Internet in the total number of museums; theaters with a website on the Internet, in the total number of theaters; of the volume of the electronic catalog available on the Internet, for each region, the Digitalization Index of the Cultural Sphere was calculated and the rating of Russian regions for 2021 was presented. The results showed that the level of digital maturity of the cultural sphere varies significantly across regions, and inequality in the level of digital development in this area also persists. Leading regions that have achieved high results in digital development, as well as lagging territories, have been identified. The classification obtained during the study allows for a more targeted implementation of cultural policy in the regions of Russia.
Beyond the Gut: The Epidemiology of Extraintestinal Manifestations in Inflammatory Bowel Disease
Authors: Boneschansker Leo , Burke Kristin E.
Published: December 2023

Inflammatory bowel diseases (Crohn's disease, ulcerative colitis) are chronic immune-mediated diseases of the gastrointestinal tract that are associated with many extraintestinal manifestations (EIMs). EIMs can affect nearly any organ system and are associated with impaired quality of life. This issue of The Clinical and Translational Gastroenterology includes a cross-sectional study of EIMs within the GETAID cohort, one of the largest to date reporting on the prevalence, risk factors, and predictors of remission for EIMs. We discuss how these results fit with existing literature and how clinicians may incorporate these insights into practice.
Children's Character Education in The Principles of Self-Identity Malay Perspective Tenas Effendy
Authors: Mukhtar Zulfadhly , Selvi Issaura Dwi , AH Nurkamelia Mukhtar
Published: December 2023

The greatest challenge in the current era of globalization and modernization is to uphold and impart moral values and character to children. There are numerous cases where children lose their direction and ethics due to the influence of various media, technology, and foreign cultures. This research aims to examine the values of early childhood character education from the perspective of Malay identity principles by Tenas Effendy. The study employs a literature review method (library research). Data collection techniques involve studying literature and documentation of Tenas Effendy's writings on Malay Identity Principles. The data analysis technique used is content analysis. The research findings indicate that the values of children's character education in the Malay identity principles perspective of Tenas Effendy encompass eight aspects: religious character, honesty, hardworking nature, independence, responsibility, social concern, environmental awareness, and friendly/communicative nature. Therefore, implementing these noble values in children can help shape a strong foundation of character. This doesn't only prepare children for academic success but also builds a moral and ethical groundwork that will guide them in facing future challenges.
Wie kann Suffizienzpolitik gelingen? Planung und Umsetzung suffizienzorientierter Stadtentwicklung durch kommunale Verwaltungen
Authors: Lage Jonas , Böcker Maike , Christ Michaela
Published: December 2023

Suffizienz ist eine Schlüsselstrategie, um Nachhaltigkeitsziele zu erreichen. Die Umsetzung von Suffizienzpolitik gilt jedoch als politisch heikel, konflikthaft und bisher wenig beforscht. Wenn Stadtverwaltungen neue Ideen des Städtischen entwickeln, kreative Finanzierungswege
finden, Ressourcen sichern und Suffizienz als Leitbild einführen, können Städte Vorreiterinnen sozial-ökologischer Transformation sein.Sufficiency policies are increasingly seen as indispensable to achieving sustainability goals. Sufficiency is a strategy to reduce
consumption and production levels by changing social practices. Municipalities are central to the implementation of sufficiency policies, as they can directly promote sufficiency through infrastructural and institutional redesign. However, as sufficiency policy relies on the redistribution
of existing resources, its implementation is considered politically divisive. The analysis of 19 qualitative interviews from twelve municipalities in Germany and Switzerland that have implemented sufficiency-oriented projects shows how municipal administrations have contributed to their successful
implementation. The administrations organise the implementation along the lines of sufficiency-oriented ideas, creatively gain access to the necessary material resources, and take on a mediating and strongly shaping role in the process design. Decoupling municipal financing from municipal
growth would be crucial to support municipalities in developing and implementing more far-reaching and extensive sufficiency policies. As our examples show, once established many sufficiency-oriented projects are widely recognised.
Who are the Better Candidates for Epilepsy Surgery?
Authors: Lee Sang Kun
Published: December 2023

The resective epilepsy surgery can be the effective procedure to get seizure-free outcome in these drug resistant epilepsy (DRE) patients. Class I evidence firmly establishes the superiority of epilepsy surgery over medical treatments in both seizure control and quality of life for DRE patients. For the effective identification of optimal surgical candidates, it's essential to understand the prognostic factors of epilepsy surgery based on the surgical methods employed. Established positive prognostic indicators for temporal resection include the presence of hippocampal sclerosis on magnetic resonance imaging (MRI), focal lesions on MRI, unilateral temporal spikes, concordant ictal electroencephalography (EEG), and a history of prolonged febrile convulsion. Potential negative predictors encompass preoperative secondary generalized tonic-clonic seizures, a normal MRI, postoperative EEG spikes, and age at the time of surgery. For neocortical epilepsy, the prognostic factors identified through multivariate analysis were the presence of a discrete lesion, localized hypometabolism on Fluorodeoxyglucose positron emission tomography (FDG-PET), and localized ictal EEG. A significant correlation was found between achieving a seizure-free outcome in no visible lesion on MRI (MR-negative) epilepsy patients and having concordance in two or more presurgical evaluations, specifically in interictal EEG, ictal EEG, FDG-PET, and ictal single-photon emission computed tomography. There was a marked improvement in the seizure-free outcome in MR-negative temporal lobe epilepsy (TLE) by the application of this strategy. The better surgical candidates for epilepsy surgery are the followings: patients displaying a discrete lesion on MRI with concordant video-EEG monitoring (VEM) results, patients diagnosed with unilateral hippocampal sclerosis who have concordant VEM results, patients with unilateral hippocampal sclerosis but discordant VEM results, patients with focal cortical dysplasia and concordant VEM results, and patients diagnosed with MR-negative TLE who exhibit two or more consistent results from presurgical evaluations.
Aphasic Status Epilepticus Associated with Alzheimer’s Disease: Clinical and Electrographic Characteristics
Authors: Lee Hyoung Cheol , Kim Byung-Kun , Kang Kyusik , Lee Woong-Woo , Yoo Ilhan , Kim Yong Soo , Lee Jung-Ju
Published: December 2023

In aphasic status epilepticus (ASE), aphasia is the sole manifestation of seizure in patients with this disorder. Alzheimer’s disease (AD) is one of neurological disorders causing ASE. Herein, we report two cases of ASE associated with AD, and discuss their clinical characteristics. Patient 1 presented Broca’s aphasia, and patient 2 presented global aphasia during the ictal period. Both patients exhibited atypical ictal electroencephalographic (EEG) patterns, which improved after antiepileptic drug administration. ASE was the presenting symptom of AD in patient 1. ASE can develop at any stage of AD. Alterations in clinical symptoms and EEG patterns after treatment with antiepileptic drug are the key to diagnosis. Prompt diagnosis and treatment are critical for preventing further consciousness dysfunction.
Evaluasi Efektivitas Pengamanan Stock BBM Solar untuk Fuel Terminal Regional Kalimantan dengan Penyediaan Fasilitas Ship to Ship (STS) Temporary Selama Periode Turn Around (TA) RU V Balikpapan
Authors: Amrulloh Riva , Windarta Jaka , Nugroho Agung
Published: December 2023

PT Pertamina Patra Niaga Regional Kalimantan membawahi 10 Fuel Terminal (FT) dan 7 Terminal Kerjasama Operasi (KSO) yang tersebar di 5 Provinsi Wilayah Kalimantan. 6 Fuel Terminal diantaranya berada di wilayah Kalimantan Timur dan Kalimantan Utara (Kaltimtara) yaitu Balikpapan, Samarinda, Pendingin, Palaran, Tarakan dan Berau. Dalam kondisi normal, Fuel Terminal tersebut mendapat pasokan BBM 100% dari Refinery Unit (RU) V Balikpapan. Pada periode Agustus-September 2022, RU V mengadakan Turn Around (TA) selama +2 bulan sampai dengan produksi normal. Selama perioda TA berlangsung, RU V tidak memproduksi BBM sehingga pasokan BBM ke Fuel Terminal dan distribusi BBM untuk layanan ke masyarakat/konsumen ritel maupun konsumen industri berpotensi terganggu. Selain tidak ada produksi, terdapat juga keterbatasan sarana fasilitas tanki timbun, jetty dan pompa yang dapat digunakan untuk penyaluran BBM ke kapal. Dari sisi material balance produk Solar, terdapat kekurangan volume supply sebesar 51.000 KL untuk memenuhi demand fuel terminal dan terdapat kebutuhan sarana fasilitas alternatif untuk penyaluran BBM ke kapal. Sehubungan dengan hal tersebut telah dilakukan strategi pengamanan stock BBM dengan optimalisasi produk dari RU lainnya dan penyediaan fasilitas Ship to Ship (STS) untuk kegiatan loading ke kapal konsinyasi tujuan Fuel Terminal wilayah Kaltimtara. Tujuan dari penelitian ini adalah untuk mengevaluasi efektifitas pengamanan stock BBM dengan indikator keberhasilan berupa kondisi stock yang aman selama periode TA berlangsung. Untuk mengetahui kondisi stock aman, penulis menggunakan analisa perbandingan rata-rata stock harian vs safety stock vs realisasi demand harian, analisa realisasi ketahanan stock vs target ketahanan stock dan analisa matbal produk solar di masing-masing fuel terminal. Dari hasil penelitian disimpulkan bahwa pengamanan stock dengan penyediaan STS Temporary cukup efektif sehingga stock BBM Solar di Fuel Terminal wilayah Kaltimtara dalam kondisi aman dengan rata-rata level stock 4.481 KL atau 33% diatas safety stock dengan ketahanan stock harian rata-rata 4.5 hari vs target minimum 3.0 hari dan posisi stock akhir positif 34.463 KL
Renewable Energy As A Green Economy Stimulus In Indonesia
Authors: Maidasari Tika , Prakoso Lukman Yudho , Murtiana Sri
Published: December 2023

Populasi dunia semakin meningkat setiap tahunnya, yang mengakibatkan peningkatan kebutuhan akan energi. Peringatannya bahwa sumber energi terbesar yang digunakan saat ini adalah energi fosil. Sumber energi fosil juga semakin menipis dan berdampak negatif seperti emisi gas rumah kaca, sehingga diperlukan solusi alternatif untuk memenuhi kebutuhan energi. Konsep Ekonomi Hijau menempatkan fokus pada kelestarian lingkungan dan mengurangi dampak negatif terhadap lingkungan. Ada banyak sektor yang mendukung ekonomi hijau, termasuk sektor energi terbarukan, yang terdiri dari panas bumi, angin, bioenergi, sinar matahari, aliran air, dan air terjun, serta pergerakan dan perbedaan suhu lapisan laut.Tujuan penelitian adalah untuk mengetahui potensi energi terbarukan sebagai stimulus ekonomi hijau di Indonesia dan bagaimana pemerintah dapat memaksimalkan manfaat dari potensi yang ada. Penelitian ini menggunakan metode kualitatif yaitu kajian pustaka. Hasil kajian menyimpulkan bahwa potensi pemanfaatan energi terbarukan di Indonesia masih sangat rendah yaitu hanya 0,3% atau sekitar 11,6 GW dari total 3.643 GW yang dapat dimanfaatkan. Untuk itu, masih banyak peluang ekonomi hijau yang bisa dicapai dengan pemanfaatan energi terbarukan. Pemerintah Indonesia telah mengambil langkah penting untuk mendorong investasi dan pengembangan energi terbarukan melalui berbagai kebijakan. Tentunya semua itu juga membutuhkan sinergi dari pemerintah, swasta, dan masyarakat agar Indonesia
Analisis Kepuasan Tenaga Kesehatan terhadap SIMPUS (Sistem Informasi Manajemen Puskesmas) di Puskesmas Sibela Surakarta
Authors: Gita Anggi Putri Aria , Surya Nella Tri , Kuraini Sri Nurul
Published: December 2023

The Sibela Surakarta Health Center has used the Management Information System of Health Center (SIMPUS) which is integrated in all sections as a flow of patient services starting from registration, polyclinic, laboratory, and pharmacy. During its implementation, SIMPUS at the Sibela Surakarta Health Center experienced various problems in data processing, one of which was a delay in the data input process to the computer caused by delays from program holders to SIMPUS officers or network delays. The purpose of this study was to analyze the satisfaction of health workers with SIMPUS at the Sibela Surakarta Health Center using the E-Servqual method. This research is a quantitative descriptive study with a cross-sectional research design using the E-Servqual method. The number of research subjects was 31 people, using quota sampling, and interviews with satisfaction questionnaires. Health workers were very satisfied with efficiency (gap value=0.01), not satisfied with reliability (gap value= -0.14), satisfied with compliance (gap value=0.00), very satisfied with privacy (gap value=0.02), dissatisfied with power responsive (gap value=-0.09), and dissatisfied with the contact (gap value=-0.08).Keywords: Satisfaction, Health Workers, SIMPUS.
Genes and Mechanisms Responsible for Expansion of Acute Myeloid Leukaemia Blasts
Authors: Dvořák Michal , Dvořáková M.
Published: December 2023

Acute myeloid leukaemia (AML) is the leading form of fatal acute leukaemia in adults. AML is a heterogeneous disease with respect to responsible mutations and chromosomal abnormalities as well as to their clinicopathological image. In recent years, great progress has been made in techniques allowing detection of genetic changes in both de novo AML and in secondary AML induced by other haematological disorders or therapy, and in detection of residual disease after therapy. Accumulated knowledge allowed better understanding of the molecules and mechanisms involved not only in the formation and expansion of a primary leukaemia-founding clone, but also of a temporal order of changes leading to the fully malignant phenotype. The recent knowledge of bone marrow (BM) compartments and interrelations among various BM resident and recruited cell types helps in understanding the AML development. The progress in the techniques and knowledge will result in the development and use of molecularly targeted therapies tailored to individual patient needs.
Trichostatin A Inhibits Rhabdomyosarcoma Proliferation and Induces Differentiation through MyomiR Reactivation
Authors: Tarnowski Maciej , Tkacz M. , Kopytko P. , Bujak J. , Piotrowska K. , Pawlik A.
Published: December 2023

Rhabdomyosarcoma (RMS) is a malignant tumour of soft tissues, occurring mainly in children and young adults. RMS cells derive from muscle cells, which due to mutations and epigenetic modifications have lost their ability to differentiate. Epigenetic modifications regulate expression of genes responsible for cell proliferation, maturation, differentiation and apoptosis. HDAC inhibitors suppress histone acetylation; therefore, they are a promising tool used in cancer therapy. Trichostatin A (TsA) is a pan-inhibitor of HDAC. In our study, we investigated the effect of TsA on RMS cell biology. Our findings strongly suggest that TsA inhibits RMS cell proliferation, induces cell apoptosis, and reactivates tumour cell differentiation. TsA up-regulates miR-27b expression, which is involved in the process of myogenesis. Moreover, TsA increases susceptibility of RMS cells to routinely used chemotherapeutics. In conclusion, TsA exhibits anti-cancer properties, triggers differentiation, and thereby can complement an existing spectrum of chemotherapeutics used in RMS therapy.
Postawy Polaków wobec aborcji w latach 1989-2023
Authors: Gębka Mikołaj
Published: December 2023

W artykule zaprezentowano zarejestrowane na przestrzeni lat zmiany w podejściu Polaków do aborcji. W pierwszej części przedstawiono stosunek ogółu respondentów do tego zagadnienia, w drugiej skupiono się na opiniach ludzi młodych. Polacy przez ponad dwie dekady stawali się coraz mniej przychylni aborcji, jednakże od roku 2016, kiedy problem aborcji po raz kolejny stał się przedmiotem sporów prawnych, politycznych i społecznych, odsetek przeciwników aborcji zaczął powoli spadać. W ostatnim okresie młodzi ludzie podchodzą do problemu aborcji bardziej liberalnie niż ogół respondentów, równocześnie wzrósł wśród młodych ludzi – a w szczególności wśród kobiet – odsetek deklaracji poglądów lewicowych. Przedmiot badań naukowych: postawy Polaków wobec aborcji; cel: prezentacja i analiza przemian stosunku Polaków do aborcji; metoda: analiza danych zastanych.
Rodzina i wiara w życiu mężczyzn osadzonych
Authors: Brzeziński Mirosław
Published: December 2023

Rodzina i wiara mimo dokonujących się szybkich zmian społecznych wciąż według wielu badań stanowią podstawowe wartości w życiu człowieka, przynajmniej w sensie deklaratywnym. Podczas swoich spotkań w z osadzonymi odbywającymi karę pozbawienia wolności w różnych zakładach karnych temat wartości, rodziny, wiary, znaczenia kary i możliwości wykorzystania tego czasu podejmowali Jan Paweł II oraz Franciszek. Posługując się metodą analizy i syntezy tekstów tych dwóch papieży zechcemy ukazać w jaki sposób mówią do osadzonych, oraz w jaki sposób ukazują te wartości, czy mają, a jeśli tak, to jakie mają znaczenie również w sposobie odbywania kary pozbawiania wolności. Chcąc ukazać jakie mają spojrzenie i rozumienie tych wartości sami osadzeni, w tym celu została przeprowadzona przez autora, krótka ankieta wśród mężczyzn odbywających karę pozbawienia wolności, a którzy otrzymali szansę i możliwość studiowania w Centrum Studiów dla Osadzonych przy Areszcie Śledczym w Lublinie, na kierunku nauki o rodzinie. Mamy świadomość, że jest to nieliczna grupa badawcza (obecnie studiuje tam ok. 30 mężczyzn), a większość z nich (ponad 70%) uczestniczyła w badaniu. Analiza tych badań pozwoli na zobaczenie, czy i jeśli tak, to jakie miejsce te wartości zajmują w tej szczególnej grupie społecznej, również w kontekście papieskiego nauczania.
Poznać kochając, kochać poznając prawdziwą rzeczywistość
Authors: Moreno-Szypowska Jadwiga Clea
Published: December 2023

Krzysztof Stachewicz, Doświadczyć prawdziwej rzeczywistości. Prolegomena do filozofii mistyki: T. 1. Filozofia doświadczenia mistycznego (ss. 396) i T. 2. Człowiek wobec doświadczenia mistycznego (ss. 245), Wyd. Uniwersytetu im. Adama Mickiewicza w Poznaniu, Wydział Teologiczny, Poznań 2019.
Artykuł poświęcony książce Krzysztofa Stachewicza Doświadczyć prawdziwej rzeczywistości. Prolegomena do filozofii mistyki: T. 1. Filozofia doświadczenia mistycznego i T. 2. Człowiek wobec doświadczenia mistycznego, wnikliwie omawia wieloletnie badania poznańskiego profesora, który jest jednym z niewielu polskich badaczy mistyki z punktu widzenia filozofii. Te dwa terminy – mistyka i filozofia – wydawać się mogą trudne do adekwatnego powiązania, nie mniej jednak od zarania dziejów idą w parze, czego dowodem jest choćby myśl Pitagorasa i jego uczniów. Krzysztof Stachewicz szczegółowo i przystępnie opisuje przebieg dziejów filozofii, głównie zachodniej, lecz nie tylko, skupiając się na tym, jak  przeżyte przez myślicieli doświadczenia mistyczne wpłynęły na ich obraz świata. Czytając tą pracę, wyłania się obraz empirycznego doznania transcendencji, nie zawsze o zabarwieniu konfesyjnym, czasami – ku zaskoczeniu – laickim, które modyfikuje filozoficzną percepcję rzeczywistości. Stachewicz najpierw dokładnie podaje, co rozumie przez omawiane pojęcia: doświadczenie, mistykę oraz filozofię, by uniknąć niejasności, którymi obleczone są w szczególności pierwsze dwa terminy. Rozumiejąc doświadczenie jako drogę do poznania prawdziwej rzeczywistości, zaś mistykę jako nastawienie pełne miłości, a filozofię jako ukochanie prawdy objawiającej się w rzeczywistości, autor śledzi tą kompilację w rozważaniach tak różnych filozofów jak starożytny Platon i XX-wieczny Bernarda Russella. Traktując filozofię w znaczeni szerszym, a więc także włączając w nią literatów, kreśli tok rozmyślań bądź doznań m. in. św. Jana od Krzyża i Georges’a Bataille’a. Nie ograniczając się do najbliższej nam kultury, badacz wyrusza na poszukiwanie tej rzeczywistości w innych kręgach: hinduizmie – skupiając się na Ramakrishnie; do buddyzmu i Buddy; judaizmu w odsłonie Filona z Aleksandrii; oraz islamu z postacią Abu Hamida al-Ghazali. Całość pracy stanowi głębokie studium historii filozofii mistyki, której pionierem w Polsce jest Krzysztof Stachewicz, zaś recenzowana książka – to jedno z pierwszym takich przedsięwzięć na skalę światową.
Wsparcie rodziny z doświadczeniem zaniedbania jako jednej z form przemocy prenatalnej
Authors: Lichtenberg-Kokoszka Emilia , Gwoździewicz Tomasz
Published: December 2023

Celem artykułu jest ukazanie możliwości wsparcia rodziny, która dotknięta jest przemocą prenatalną spowodowaną zaniedbaniem. Poprzez analizę samego zjawiska oraz przyczyn i następstw jego występowania dokonano syntezy, która pozwala określić konkretne działania wspierające rodzinę dotkniętą tym problemem. Uzyskana synteza ukazuje przemoc prenatalną jako zjawisko wielopłaszczyznowe, a wsparcie rodziny powinno dokonywać się poprzez stosowanie właściwej semantyki, wspieranie umiejętności dialogu z dzieckiem w okresie prenatalnym, a także konkretne działania instytucjonalne i edukacyjne.
Blood over-testing: impact, ethical issues and mitigating actions
Authors: Pennestrì Federico , Tomaiuolo Rossella , Banfi Giuseppe , Dolci Alberto
Published: December 2023

Plenty of studies demonstrate that hospital-acquired anemia (HAA) can increase transfusion rates, mortality, morbidity and cause unnecessary patient burden, including additional length of hospital stay, sleep disruption and venipuncture harms resulting from blood samples unlikely to change clinical management. Beyond patient costs, community costs should also be considered, such as laboratory time and resources waste, environmental impact, increasing pressure on labs and fewer tests available on time for patients who can benefit from them most. Blood over-testing does not support the principles of non-maleficence, justice and respect for patient autonomy, at the expense dubious beneficence. Reducing the number and frequency of orders is possible, to a certain extent, by adopting nudge strategies and raising awareness among prescribing doctors. However, reducing the orders may appear unsafe to doctors and patients. Therefore, reducing blood volume from each order is a better alternative, which is worth implementing through technological, purchasing and organizational arrangements, possibly combined according to need (smaller tubes, adequate analytic platforms, blind dilution, blood conservative devices, aggregating tests and laboratory units).
Optimal lock-down intensity: A stochastic pandemic control approach of path integral
Authors: Pramanik Paramahansa
Published: December 2023

The aim of this article is to determine the optimal intensity of lock-down measures and vaccination rates to control the spread of coronavirus disease 2019. The study uses a stochastic susceptible-infected-recovered (SIR) model with infection dynamics. A Feynman-type path integral control approach is used to derive a forward Fokker-Plank-type equation for the system, which helps in performing a stochastic control analysis. The simulation study concludes that increasing the diffusion coefficients leads to a downward trend in the susceptible and recovery curves, while the infection curve becomes ergodic. Additionally, the study shows that the optimal lock-down intensity is stable around zero, and the vaccination rate increases over time.
Between a Dream and Its Realization: Locating Utopia and Zionism in Kafka’s American Story
Authors: Shelly Joshua David
Published: December 2023

This article analyzes Franz Kafka’s first novel, Der Verschollene, as an extended meditation on the immigrant’s experience of frustration when he relies on old national, social, and familial constellations grounded in another, far-off place; it thereby demonstrates how the novel depicts immigration as primarily a tale of loss, rather than gain. The article then pivots to situate Der Verschollene, and especially the novel’s final fragment, in light of Kafka’s passionate consumption of both American travelogues and Zionist periodicals and literature. In light of this literary-historical backdrop and the Kafka short story, Wunsch, Indianer zu werden, it argues that the departure of the novel’s main character for “Oklahama” at the end of the work is an implicit celebration of literary travel narratives for their ability to achieve something real-life migration never can: a utopian moment suspended between a dream and its fulfillment.