bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro Antioxidant Potential and In vivo Analgesic and
Anti-Inflammatory Activities of Moroccan Equisetum ramosissimum
Authors: Larhsini Mustapha , Sissi Saida , Dra Loubna Ait , Ouhaddou Soukaina , Ahmed Ouhammou , Markouk Mohammed
Published: May 2022

Background:

Equisetum ramosissimum is a pteridophyte plant used in Moroccan traditional
medicine for its diuretic and antidiabetic properties. The species is known to reduce blood
cholesterol levels and is given in cases of gonorrhea.

Objective:

The present work aims to explore the potential use of the crude butanolic (BE) and methanolic
(ME) extracts of E. ramosissimum in the management of pain, inflammation and oxidative
stress, and their chemical characterization.

Methods:

The phytochemical investigation of E. ramosissimum was initially done by colorimetric
methods, followed by High Performance Liquid Chromatography coupled with Mass Spectroscopy
(HPLC-MS). Its antioxidant activity was evaluated using radical scavenging activity in 2,2-
diphenyl-1-picrylhydrazyl radical (DPPH), reducing power and β-carotene/linoleic acid bleaching
assays. The analgesic activity was evaluated by acetic acid in mice and hot-plate-test in rat models.
Rate paw edema and ear edema were used as anti-inflammatory models.

Results:

The chemical quantification revealed appreciable levels of phenolic compounds. The results
of HPLC-UV and HPLC-MS highlighted the presence of kaempferol3-O-sophoroside7-Oglucoside,
kaempferol3,7-O-diglucoside, vanillin, ferulic acid and tannic acid. The maximum IC50
was obtained for BE by DPPH test (0.064±0.0004mg/mL). BE exhibited an interesting antinociceptive
effect; inhibition of writhes, 3.83±0.48 at 600mg/kg, increased the latency period on the hotplate-
test, i.e., 14.98S±0.57S at 400mg/kg after 120min. Furthermore, the results reported a significant
inhibition of rate-paw edema and ear edema for both extracts at a dose of 400mg/kg.

Conclusion:

BE and ME of E. ramosissimum were found to contain a significant amount of flavonoids,
especially derivatives of kaempferol, which can explain the interesting effectiveness properties.
Possible applications in the food and pharmaceutical industries are suggested.
Diet and miRNA: Epigenetic Regulator or a New Class of Supplements?
Authors: Cannataro Roberto , Cione Erika
Published: May 2022

It is well recognized that diet components are important genomic regulators considering
that food intake influences cytokines such as leptin, ghrelin, adiponectin, and NPY, which regulate
gene expression in response to different nutritional programs, particularly regarding the caloric balance.
However, the single nutrients, both the macro-nutrients, the fatty acids, and above all the micronutrients,
show an essential capacity also for epigenetic regulation; in this sense, vitamins and
their derivatives polyphenols are the main actors.
Acyclic Polyorganochalcogenoethers and their Functional Activities: Synthesis of Sterically Encumbered Hexakis(alkylchalcogenomethyl)benzenes [(RECH2)6C6] [E=S or Se] and their Potential as Selective Ionophores for Hg2+Ions
Authors: Prabhu Nallamuthu , Jyoti  , Kumari Renu , Singh Jai Deo , Butcher Raymond J.
Published: May 2022

Introduction:

An efficient synthesis of hexakis(alkylthio/selenomethyl)benzenes [(RSCH2)6C6 and (RSeCH2)6C6] (1-14) (where, R= nPr, iPr, nBu, iBu, sBu, tBu, nPent, iPent, and 2-Methyl-1-butyl) by the reaction of hexakis(bromomethyl)benzene with alkylthio or alkylseleno (RS-/RSe-) anions are demonstrated.

Methods:

They have been characterized by physicochemical and spectroscopic methods including single crystal X-ray crystallography. The balances between multiple [C(sp3)-H…S] or [C(sp3)-H…Se] intramolecular interactions in these species appear to decide their stability. Preliminary spectroscopic (UV-vis. and fluorescence) data on the behavior of alkylchalcogeno substituted hexa-benzenes in solution revealed their potential as ion-sensing species and function as highly selective ionophores for Ag+ and Hg2+ ions recognition.

Results:

In situ, (Hg-S) and (Hg-Se) bond formation on interaction with the chosen hexa-species (2 and 10) and Hg2+ cation revealed a unique ‘turn-off’ or ‘turn-on’ emissive behavior and these function act as reporting fluorescent tool for Hg2+ quantification without use of any external fluorophore.

Conclusion:

The present study describes an efficient and simple route for the synthesis of sterically encumbered poly-alkylthio/seleno benzenes in high purity and good yields.
WITHDRAWN: Air Pollution as Causative Factor for Death: Environmental Forensics for Ella Adoo Kissi Debrah Death Case
Authors: Rawtani Deepak , Dave Hemen , Mohite Vrushali , Patel Shruti , Pandey Akanksha
Published: May 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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of their article is transferred to the publishers if and when the article is accepted for publication.
KEANEKARAGAMAN JENIS JAMUR PATOGEN SERANGGA ASAL TANAH PADA SISTEM AGROFORESTRI PINUS-KOPI DI HUTAN PENDIDIKAN UNIVERSITAS BRAWIJAYA
Authors: Pertiwi Kenya Mustika , Afandhi Aminudin
Published: May 2022

Alih fungsi lahan di Hutan Pendidikan Universitas Brawijaya (HPUB) telah terjadi sejak tahun 1976. Sebagian besar area di HPUB telah banyak diubah menjadi lahan pemukiman, pertanian, perkebunan, dan hutan produksi. Hal ini menjadi penyebab utama penurunan diversitas mikroorganisme tanah seperti serangga, jamur, bakteri, cacing tanah, amuba dan jasad renik lainnya. Penerapan sistem agroforestri dapat ditawarkan dalam mengatasi masalah yang timbul akibat adanya alih fungsi lahan, karena sistem tersebut dapat meningkatkan keanekaragaman dan populasi mikroorganisme tanah seperti jamur. Jamur merupakan salah satu organisme yang dominan hidup di dalam tanah. Salah satu jamur asal tanah yang berperan sebagai pengendali hayati adalah jamur patogenik serangga (JPS). Tujuan dari penelitian ini yaitu untuk mengetahui keanekaragaman jenis JPS asal tanah pada sistem agroforestri pinus–kopi di HPUB dan untuk mengetahui faktor lingkungan abiotik yang mempengaruhi keanekaragamannya. Sampel tanah diambil dari 5 titik pada sistem agroforestri pinus-kopi. JPS yang berhasil diisolasi kemudian dipurifkasi dan diidentifikasi. Data jenis dan populasi JPS yang diperoleh dianalisis untuk menentukan keanekaragaman dan kelimpahan jenis menggunakan rumus: indeks keanekaragaman jenis, indeks dominansi jenis, indeks kekayaan jenis dan indeks kemerataan jenis. Berdasarkan hasil penelitian, diperoleh 15 isolat koloni jamur yang terdiri dari 6 genus yaitu Aspergillus, Penicillium, Gongronella, Fusarium, Mortierella dan Metarhizium. Nilai indeks keanekaragaman (H’) sebesar 1,894, nilai indeks dominansi (C) sebesar 0,182, nilai indeks kekayaan (D) sebesar 2,585, dan indeks kemerataan jenis (E) sebesar 0,911. Berdasarkan analisis deskriptif, maka intensitas cahaya, pH tanah, suhu tanah, suhu udara dan kelembaban relatif berpengaruh terhadap keanekaragaman JPS pada sistem agroekosistem pinus-kopi.
PENGUJIAN KONSORSIUM BAKTERI ANTAGONIS UNTUK MENGENDALIKAN PENYAKIT LAYU FUSARIUM PADA TANAMAN BAWANG MERAH (Allium ascalonicum L.) DI KECAMATAN DAMPIT, KABUPATEN MALANG
Authors: Aprilia Alda Dwi , Aini Luqman Qurata
Published: May 2022

Bawang merah merupakan komoditas hortikultura yang menjadi sumber pendapatan bagi perekonomian Indonesia hingga ± Rp. 2,7 Trilliun/tahun. Salah satu faktor yang menyebabkan produksi bawang merah di Indonesia mengalami penurunan yaitu akibat serangan jamur Fusarium oxysporum. Penelitian ini bertujuan untuk mengetahui efektivitas konsorsium bakteri antagonis P. aeruginosa, B. cereus 1 dan B. cereus 2 dalam mengendalikan penyakit layu fusarium dan meningkatkan pertumbuhan tanaman bawang merah. Tahapan penelitian meliputi: penentuan plot dan tanaman contoh, peracikan isolat bakteri, pengaplikasian isolat bakteri, pengamatan komponen pertumbuhan, tingkat kejadian penyakit layu Fusarium, tingkat efikasi, hasil panen dan analisis data menggunakan Rancangan Acak Kelompok (RAK) terdiri dari 9 perlakuan dan 3 ulangan. Pengaplikasian konsorsium bakteri antagonis perlakuan P9 (P. aeruginosa + B. cereus 1 + B. cereus 2) sangat efektif dalam menekan perkembangan penyakit layu fusarium serta dalam memacu pertumbuhan pada tanaman bawang merah. Tingkat efikasi tertinggi yaitu pada perlakuan P9 dengan nilai sebesar 81% lebih tinggi dibandingkan dengan perlakuan lainnya.
UJI DAYA RACUN EKSTRAK DAUN BINTARO (Cerbera odollam Gaertn.) TERHADAP MORTALITAS KUTUDAUN (Aphis gossypii Glover) (HEMIPTERA: APHIDIDAE) PADA TANAMAN CABAI MERAH (Capsicum annum L.)
Authors: Santi Lindia Rahayu Widia , Himawan Toto , Ikawati Silvi
Published: May 2022

Salah satu hama utama yang menyerang dengan intensitas tinggi pada tanaman cabai adalah kutudaun (Aphis gossypii Glover). Bentuk pengendalian hama ini yang sering dilakukan adalah dengan penggunaan insektisida sintetik. Penggunaan insektisida sintetik dapat menyebabkan berbagai dampak negatif terhadap lingkungan, sehingga dibutuhkan bentuk alternatif pengendalian yang lebih ramah lingkungan. Salah satu alternatif pengendalian tersebut dapat menggunakan insektisida nabati. Penelitian ini menggunakan ekstrak daun bintaro (Cerbera odollam Gaertn.), untuk mengevaluasi pengaruhnya terhadap kutudaun. Ekstrak daun bintaro (EDB) dapat digunakan untuk mengendalikan A. gossypii dengan nilai LC50 pada konsentrasi 2166,63 ppm dan LT50 pada 16,71 jam setelah aplikasi.
Evaluation of chewing ability in cerebrovascular accident and Parkinson’s disease
Authors: Kim Ja Young , Lee Sang-eok , You Hee-Cheon , Kim HyangHee
Published: May 2022

Purpose: Chewing problems are a major and prevalent issue in populations with neurological pathologies including cerebrovascular accident (CVA) and Parkinson’s disease (PD). We measured habitual solid chewing performance in patients with CVA or PD and compared it to that of normal older adults to identify differences in chewing ability between groups.Methods: Measures of habitual solid chewing in 32 patients with CVA, in 35 patients with PD, and in 217 normal older adults were compared. Data on the chewing duration, frequency, and rate were collected using a solid chewing task (SCT). We also analyzed the relationships between dentures, number of teeth, and SCT outcomes.Results: The chewing duration in the PD group was significantly longer than the normal group (p<0.05). Chewing frequency and rate were not significantly different among the three groups. Results can be explained by rigidity and bradykinesia in orofacial structures in the PD group. No significant differences between the PD and CVA groups may be partly explained by the diverse location and size of the CVA lesion compared to the PD. Dentures and the number of teeth were not significantly correlated with SCT outcomes.Conclusions: Chewing impairment remains the area of development for research and rehabilitation, and SCT may help to assess oropharyngeal dysphagia and to identify therapeutic interventions.
A comparative study on parental language used by parents of children with Autism Spectrum Disorder and typically developing children
Authors: Mohan P Veena , Mahasoomi H Marjana , Davis Divya Anna
Published: May 2022

Purpose: Current study is designed to analyze the quantity and quality of parental language during parent-child interaction in the natural environment in both typically developing and in children with autism spectrum disorder.Methods: A total of 10 primary caregivers mainly parents in which 5 participants were parents of children with autism spectrum disorder and 5 participants were parents of typically developing children. A 10-15 minutes video recording of parent-child interaction was analyzed and drawn into conclusion about the quantity and quality of language used in terms of grammatical language measures, discourse function and pragmatic function.Results: Parents of children with ASD and parents of TD children who were developing normally produced similar amounts of linguistic input, but they differed on certain quality parameters. Parents of TD children use more Mean Length of Utterance. Significant differences were found between the two groups in terms of Discourse function and pragmatic functions. The parents of children with ASD used a comparatively lower number of nouns, verbs, conjunctions and case markers. In Discourse function analysis, significant differences were found in parental responses, number of conversational turns and number of parental responses to child’s initiations. While considering pragmatic/behavioral functions, significant differences were only in questions and expansions.Conclusions: The current study emphasizes the importance of parental language during parent-child interactions, as well as the need to profile the same which would provide precise information on the level of stimulation delivered.
The textual Distance and the Transportable Interpretation," from two texts by Anwar Qadir Jaff and Qubadi Jali Zada
Authors: Hussein Ali Tahir , Qadir Abbas Muhammed
Published: May 2022

This paper is under the title of "The textual Distance and the Transportable Interpretation," from two texts by Anwar Qadir Jaff and Qubadi Jali Zada. This analysis is part of the PH.D. research under the title of "Reception Theory and the Criticism of Kurdish poetry," in which two concepts such as textual distance and transportable interpretation have been discussed; moreover, Wolfgang Iser was the actual person who founded those two mentioned concepts. Above all, Iser was fundamentally one of the leaders of reception theory. Then, this analysis aims at clarifying the way those two concepts deal with the texts to gain their appropriate meanings. After that, this argument between those two concepts and their effects on texts has been practiced in the 'Talesim and Ay Way Zara Gyan,' which were two challenging texts. In the end, the achieved aims have been identified.
Producción clonal de material de siembra de guayabo mediante la técnica de injertación en púa termina
Authors: Rodríguez Henao Eberto , Grajales Guzmán Luis Carlos , Ossa Gutiérrez Julián , Cañar Serna Dubert Yamil
Published: May 2022

La creciente demanda de material de propagación de guayabo con calidad genética, física, fisiológica y sanitaria en el país ha dinamizado la expansión de este cultivo y ha generado interés en su manejo técnico y procedimental, tanto para las variedades mejoradas como para el material regional seleccionado por el agricultor. Sin embargo, el productor de semilla de guayabo afronta diversos retos que han dificultado el éxito en la cadena de abastecimiento y en la logística de producción del material de siembra, lo que, a su vez, ha limitado el potencial de esta especie frutícola en calidad y desempeño agronómico. Frente a tal perspectiva, este manual plantea de manera breve y mediante un lenguaje sencillo una serie de recomendaciones para el desarrollo apropiado de las prácticas agrícolas asociadas a cada etapa en la producción de plantas injertadas de guayabo. Además, proporciona un esquema de identificación y manejo de los principales puntos críticos en cada etapa del proceso (desde la semilla en los huertos básicos o lotes de plantas madre hasta la etapa de vivero), bajo el marco de la normatividad vigente trazada por la entidad de control. El objetivo de este material bibliográfico es reducir el riesgo de pérdida y mejorar los procedimientos técnicos para el establecimiento de nuevos cultivos de guayabo o renovación del material en áreas existentes.
Mecanismos de defensa en plantas de Capsicum contra Phytophthora capsici
Authors: Gaibor-Vaca Darlyn G. , García-Bazurto Génesis L , Garcés-Fiallos Felipe R.
Published: May 2022

Phytophthora capsici es un oomiceto causante de la pudrición de raíz, tallo, frutos y tizón foliar en varias especies vegetales de importancia agrícola, principalmente en Solanáceas del género Capsicum como ají y pimiento. Este fitopatógeno cosmopolita posee mecanismos de ataque que favorecen la rápida infección, colonización y reproducción en huéspedes susceptibles. Contrariamente, estos procesos son retrasados o evitados fuertemente por genotipos resistentes, debido principalmente a sus mecanismos de defensa. En esas interacciones incompatibles, las plantas resistentes de Capsicum reconocen el oomiceto y rápidamente expresan múltiples genes que posteriormente señalizan moléculas, que permiten la acumulación de compuestos fenólicos, fitoalexinas y especies reactivas de oxígeno, la actividad de diferentes enzimas, que pueden permitir incluso la formación de barreras físicas. Esta revisión aborda, expone y discute los avances y el progreso de las investigaciones a lo largo de los ultimos veinte años, referente a los mecanismos de defensa estructurales, bioquimicos y moleculares que utilizan las plantas resistentes de Capsicum para defenderse de P. capsici.

Palabras claves. ají, pimiento, pudrición de raíz y corona, tizón foliar, resistencia vegetal
Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting Among Civil Servants With Overweight and Obesity: Study Protocol for a Nonrandomized Controlled Trial
Authors: Abdullah Shazana Rifham , Azizul Nur Hayati , Wan Mohd Zin Ruziana Mona , Sulaiman Nur Suffia , Mustafa Khalid Norhayati , Mohd Salim Mullahi Jahn Roshan Jahn , Khalil Muhamad Khairul Nazrin , Abu Seman Norhashimah , Zainal Abidin Nur Azlin , Ali Azizan , Tan You Zhuan , Omar Azahadi , Johari Mohammad Zabri , Abdul Aziz Nur Shahida , Baharudin Azli , Seman Zamtira , Ibrahim Wong Norazizah , Md Rasip Mona Lisa , Yusof Hayati Mohd , Md Noh Mohd Fairulnizal
Published: May 2022

Background

Overweight and obesity among adults are a growing global public health threat and an essential risk factor for various noncommunicable diseases. Although intermittent fasting is a generally new dietary approach to weight management that has been increasingly practiced worldwide, the effectiveness of 2 days per week dry fasting remains unclear.

Objective

The Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting study aims to determine the cardiometabolic, anthropometric, dietary intake, and quality of life changes among civil servants with overweight and obesity, following combined intermittent fasting and healthy plate (IFHP) and healthy plate (HP) and explore the participants’ experiences.

Methods

We designed a mixed methods quasi-experimental study to evaluate the effectiveness of the IFHP and HP methods among adults with overweight and obesity. A total of 177 participants were recruited for this study, of which 91 (51.4%) were allocated to the IFHP group and 86 (48.6%) to the HP group. The intervention comprised 2 phases: supervised (12 weeks) and unsupervised (12 weeks). Data collection was conducted at baseline, after the supervised phase (week 12), and after the unsupervised phase (week 24). Serum and whole blood samples were collected from each participant for analysis. Data on sociodemographic factors, quality of life, physical activity, and dietary intake were also obtained using questionnaires during data collection.

Results

Most of the participants were female (147/177, 83.1%) and Malay (141/177, 79.7%). The expected outcomes of this study are changes in body weight, body composition, quality of life, physical activity, dietary intake, and cardiometabolic parameters such as fasting blood glucose, 2-hour postprandial blood glucose, hemoglobin A1c, fasting insulin, and lipid profile.

Conclusions

The Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting study is a mixed methods study to evaluate the effectiveness of combined IFHP and HP interventions on cardiometabolic and anthropometric parameters and explore participants’ experiences throughout the study.

Trial Registration

ClinicalTrials.gov NCT05034653; https://clinicaltrials.gov/ct2/show/NCT05034653

International Registered Report Identifier (IRRID)

RR1-10.2196/33801
EZETIMIBE NANOSTRUCTURED LIPID CARRIERS (NLCs): A NEW TECHNIQUE TO OVERCOME THE LIMITATIONS OF ORAL ADMINISTRATION
Authors: M. KAOUD RASHAD , HEIKAL EMAN J. , GAD SHADEED
Published: May 2022

Objective: Ezetimibe (EMB) is a commonly used lipid-lowering medication that lowers cholesterol and triglycerides. Because of its lower water solubility and hepatic metabolism, it necessitates the formulation of drug delivery systems that are capable of improving solubility and avoiding hepatic effect.
Methods: Ezetimibe nanostructured lipid carriers (EMB-NLCs) were formulated and examined. They were formulated through emulsification with a high homogenization speed and ultrasonication (The method and evaluation parameters have been mentioned under method section in Formulation of EMB-NLCs paragraph).
Results: The formulated NLCs have exhibited particle size (P. S.) between 163.6±7.20 and 866.66±18.65 nm and the zeta potential (Z. P.) values have ranged between-24±1.25 and-35±0.25 mV. Besides, they exhibited higher EE% than 77 percent and the drug encapsulated in lipid matrix was in amorphous state. Pharmacokinetics of optimized formula (F1; composed of 2% w/w Gelucire® 43/01, 8% w/w Miglyol® 812 N, 0.5% w/w lecithin and 2% w/w Poloxmer® 188) have exhibited 2.63-and 2.33-fold increase in oral bioavailability in comparison with EMB suspension and marketing product (Ezetrol® 10 mg tablet), respectively.
Conclusion: These studies have demonstrated that, NLCs are superior for enhancing in vivo behavior and oral bioavailability of EMB.
DONEPEZIL HYDROCHLORIDE LOADED SOLID LIPID NANOPARTICLES: FORMULATION, IN VITRO–IN VIVO PHARMACOKINETIC AND PHARMACODYNAMICS EVALUATION
Authors: DEVI A. REKHA , M. VIDYAVATHI
Published: May 2022

Objective: The aim of the present study was to design and in vitro–in vivo evaluation of Donepezil Hydrochloride solid lipid nanoparticles (DHSLN).
Methods: A modified solvent injection method was used to produce Donepezil-loaded solid lipid nanoparticles. A Response Surface Method 3-factor, 2-level Box-Behnken design was applied to study the effect of independent variables on dependent variables. Then it was coated with tween 80 for ease of permeability through the blood-brain barrier due to intact absorption of solid lipid nanoparticles. The prepared SLN was evaluated for particle size, zeta potential analysis, Entrapment efficiency, In vitro drug release study, Field Emission-scanning electron microscopy, In vivo Pharmacokinetic and Pharmacodynamics studies.
Results: The results of coated optimized formulation showed an average particle size of 185.8 nm, entrapment efficiency of 78.52±2.54%, and in vitro drug release of 98.62±3.14% at 36h at pH 7.4. The pharmacokinetic data show higher Cmax and improved bioavailability, which was also supported by behavioural changes observed in locomotor activity for surface-modified SLN formulation.
Conclusion: Thus, the current study successfully designed, developed an optimized SLN formulation. The surface-modified SLN proved to enhance the permeability of the drug through barrier, which led to the enhancement of Donepezil bioavailability and locomotor activity.
DEVELOPMENT AND EVALUATION OF SELF EMULSIFIED DRUG DELIVERY SYSTEM OF EMBELIN FOR THE TREATMENT OF AMOEBIASIS
Authors: LAL BHARAT , GADEWAR MANOJ , GARG ARUN
Published: May 2022

Objective: Development and evaluation of self-emulsified drug delivery system of embelin for the treatment of amoebiasis.
Methods: Self-emulsifying drug delivery systems (SEDDS) were prepared by determining the saturation solubility of embelin in different oil, surfactant and co-surfactant. Pseudo-ternary phase diagram was prepared by using chemix software for the selection of surfactant and co-surfactant ratio, and was optimized as 2:1 (Surfactant: Co-surfactant) for SEDDS. The drug was dissolved in surfactant, followed by the addition of co-surfactant and oil in a beaker. The resultant mixtures were stirred continuously by magnetic stirrer and heated at 40 °C to obtain a homogenous mixture. The prepared drug-loaded SEDD formulation was optimized on the basis of emulsification time, size, PDI, zeta potential and precipitation of drugs. Then the anti-amoebic activity of embelin and metronidazole-loaded SEDDS powder was carried out using microplate reader.
Results: The optimum solubility of embelin was calculated in Capmul MCM EP as oil (37 mg/ml), Kolliphor hs 15 as surfactant (150 mg/ml) and PEG 400 as co-surfactant (19 mg/ml). The formulation F7 i.e. 70% Smix and 30% oil was estimated as optimized formulation. The different values of emblein loaded SEDDS was found to be dilution test (no sign of precipitation), centrifugation test (no sign of phase separation), globule size (Dia 217.5 nm) and PDI (108), zeta potential determination (-31.60 mV), viscosity (17.12 cps) and Eosin red confirmed the o/w type of emulsion. Moreover, the angle of repose SEDDS prepared by using Avicel 200 was found to be Θ=27.474, means flow of powder is good with drug loading capacity of 92.7 %. SEM image and in vitro drug release indicated the 99.3% drug was released from the SEDDS in 120 min. Cytotoxicity study (MTT assay) shows the Plain Drug Suspension, Embelin loaded SEDDS powder and Metronidazole exhibited 100% viability at the concentration range of 1.56-100 mmol. The anti-amoebic IC50 values of embelin, metronidazole and embelin loaded SEDDS powder was found 1.519 µmol, 1.354 µmol, 1.84 µmol and 1.35 µmol, respectively.
Conclusion: Present study showed the stronger amoebicidal action of embelin may associated with some specific interaction of the active embelin with the cell wall of the parasites or with a more effective mechanism of penetration into the parasites through membrane channels.
Cost–effectiveness of concurrent radiation with cetuximab or chemotherapy in older patients with oropharyngeal cancer
Authors: Albarmawi Husam , Cullen Kevin J , Mehra Ranee , Onukwugha Eberechukwu , Goloubeva Olga
Published: May 2022

Aim:
To assess the cost–effectiveness of definitive therapies for nonmetastatic oropharyngeal cancer (OPC).
Materials & methods:
Using the Surveillance, Epidemiology and End Results-Medicare dataset, patients diagnosed between 2000 and 2011 were identified. The cost–effectiveness of chemoradiation (CRT) versus radiotherapy (RT), cetuximab plus RT (cetuximab-RT) versus RT and cetuximab-RT versus CRT were estimated.
Results:
The incremental cost–effectiveness ratio for CRT compared with RT from 2000 to 2005 was US$56,650 (95% CI: US$4,522–$288,688) per additional year of survival. CRT was dominated by RT from 2006 to 2011. Cetuximab-RT was dominated by RT and CRT.
Conclusion:
CRT had a favorable value from 2000 to 2005 but was dominated by RT from 2006 to 2011. The value of cetuximab-RT compared with RT/CRT was not favorable with similar/inferior survival and substantial incremental costs.
Analysis and Simulation of Inter-Turn Fault Of Synchronous Generator Using MATLAB
Authors: Awachat Mr. Saurabh , Raulkar Mr. Piyush , Gakre Mr. Umesh , Mude Er. Sandeep K.
Published: May 2022

Abstract: The paper represents a comprehensive analysis of the inter-turn faults of a synchronous generator. In today's power system, we have used three phase synchronous generator to generate electric power, thus we all always try to reduce the loss in order to improve the efficiency of the alternator. We basically focus more on the stator winding faults. Stator winding has unbalanced loading, field failure and stator winding fault (including line to ground fault, line to line fault and double line to ground fault, three phase fault and inter turn fault) Alternator stator inter turn faults are considered to be rare and therefore they are not taken into that serious consideration while designing the protection system for the alternator. But we knew that there could be an inter-turn short circuit fault in the stator winding of the alternator. Early detection of inter turn faults will eliminate damage to the stator core and adjacent coils, reducing repair costs and generator outage times. Since inter turn fault causes imbalance in phase voltage, this concept is discussed in this paperfor inter turn fault detection. The negative sequence voltage of the generator is used as a fault indicator for inter turn fault detection. This new approach is done using MATLAB software. Also, this method works for external as well as internal fault and helps in keeping the generator winding healthy. Keywords: Inter Turn fault, internal and external faults, Internal Negative, Sequence Generator Voltage.
Effect of Core Geometry, Orientation and Support on the Core Shift in Mould
Authors: Ambhore Sudhakar S. , Gadhave Alisha , Lewis Hansel , Lobo Kenneth , Wani Ritwik
Published: May 2022

Abstract: This paper focuses on how to improve the effect of core geometry and its orientation when core shift occurs in the mould. Core shift is the change in position of the core from its original position in the mould before the molten fluid is passed into the cavity. Core shift occurs due to the temperature difference in the mould box and the pressure induced on the side walls of the mould box. Thus, the final product will have unexpected and uncountable variations and defects which will have a huge impact on the mechanical properties which in turn will affect the performance when running an operation. Also, the design and analysis of the final product will give an estimation on the various stresses acting on the core and how it will eventually affect both the mould and the core during the casting process. The problem of core shift has been resolved and the results obtained from the correction, have made an impact on the small foundries which usually do not operate in a systematic way. Thus, the goal of minimal to absolutely zero core shift can be achieved and the new final product will have more advantages compared to the old product with defects. Keywords: Core shift, Cavity, Knuckle joint, Fork end, Sand casting, Core, Mould.
Design and Fabrication of Solar Automatic Cow Dung Cleaner
Authors: Dharmik Ankush , Nagpure Jitendra , Khanorkar Sahil , Kshirsagar Shubham , Lokhande Vinay , Matey Prof. M. S.
Published: May 2022

Abstract: In today`s scenario farmers are having hard time in maintaining the cow shed to clean the cow dung they have to spend more time or they have to hire workers for more money. So in this paper we suggest a mechanism which is used to collect the cow dung and also used to clean the area. We use cow dung cleaning machine which runs under the power generated by solar. By using this process automatically human power will be saved. Keywords: Animal Cleaner, Solar, Motor, Power Transmission, Torque
Deep Learning based Skin Cancer Classifier using MobileNet
Authors: Khandizod Sayali , Patil Tejaswini , Dode Atharva , Banale Varad , Bawankar Prof. C. D.
Published: May 2022

Abstract: Skin cancer is a major problem faced by the public and it has been on the rise since the advent of global warming. The erosion of ozone has led to the Sun’s ultraviolet rays to directly reach the earth and cause many skin diseases. Primary sources of diagnosis include external examination and biopsy, histopathological analysis and dermoscopic analysis. These methods need skilled individuals or else the accuracy of diagnosis will be very low. If the skin cancer is not detected early, it may be lethal to the patient. As the cancer is external, we can use the images captured of the lesions for analysis. We propose a seven-way skin cancer classifier algorithm based on convolutional neural networks that will give results comparable to skin specialists in the diagnosis of skin cancer from skin lesion images. Transfer learning is a tool at our disposal to improve the accuracy of our system by using pre-trained models. TheHAM10000 dataset is a collection of 10000 dermoscopic images of skin lesions which can be used to train the model. We can use the MobileNet model on the dataset to build a model. We measured the accuracy of the model as categorical, top-2 and top 3 and obtained a categorical accuracy of 85%, top-2 accuracy of 91% and top-3 accuracy of 96%. This tool can assist doctors in early detection of skin cancer. Keywords: Skin Cancer Detection, Melanoma, HAM10000, Convolutional Neural Networks, Transfer Learning, MobileNet
Understanding In-Depth About Data Centre Security: Core Concepts & Market Growth
Authors: Sinha RIshabh
Published: May 2022

Abstract: Enterprises often perceive Data Centers as a key resource and demand dedicated security initiatives. Further, the emergence of security of the Data Center is playing a critical role in security-critical applications and data in a virtualized environment through optimal safeguarding. The providers of the Data Center have increased their focus. They have shown their participation in the market by enhancing products to augment the increasing demand for Data Center security solutions to address the rising needs of growing industries. This paper discusses various concepts of Data Center security along with its projected market growth on a global level. Keywords: Data Centers, Data Center Security, Data Center Security Importance, Data Center Security Market Growth, Data Center Security Practices
Review Paper on Covid 19: Data Mining Approach for Diagnosis and Treatment
Authors: Yadav Miss. Priya , Tuteja Dr. R. R.
Published: May 2022

Abstract: The outbreak of Severe Acute Respiratory Syndrome Coronavirus 31 2 (SARS-COV-2) has caused more than 2.5 million cases of Corona Virus Disease 32 (COVID-19) in the world so far, with that number continuing to grow. To control the 33 spread of the disease, screening large numbers of suspected cases for appropriate 34 quarantine and treatment is a priority. Pathogenic laboratory testing is the gold 35 standard but is time-consuming with significant false negative results. Therefore, 36 alternative diagnostic methods are urgently needed to combat the disease. Based 37 on COVID-19 radio graphical changes in CT images, we hypothesized that Artificial 38 Intelligence’s deep learning methods might be able to extract COVID-19’s specific 39 graphical features and provide a clinical diagnosis ahead of the pathogenic test, thus 40 saving critical time for disease control Keywords: COVID-19, Computed Tomography, Artificial Intelligence, Deep Learning, Diagnosis
Review on Design of Rooftop Rainwater Harvesting in Gandhi Institute for Technology (GIFT), BBSR
Authors: Mohapatra Sourav Ranjan , Dash Truptimayee , Choudhury Priyanka , Mohanty Prof. Gayatri , Swain Dr. Satyananda
Published: May 2022

Abstract: Water is the main asset on the earth. Which requires water for different exercises in our everyday life at the rate at which India's general population is growing, it is said that India will undoubtedly replace China from its fundamental place as the most thickly populated country in the world. This will provoke a high pace of use of most huge trademark resource "Water" achieving development of loads on the permitted freshwater resources and supply of it is diminishing at a quickly protected on this planet. Remembering the ultimate objective to proportion and deal with our step by step interest in water essential, we need to think of elective adroit and respectably easier mechanical methodologies of preserving water. The specialized part of this venture is water harvesting gathered from GIFT main building rooftop. Above all else, a little piece of the rooftop is taken where a steep slant is available where water overflows streams and the point of this venture is to gather and store that water and use the water by giving a legitimate method for filtration. The task begins by gathering some significant investigations on water Harvesting and concentrating on them. A legitimate arranging work led to GIFT for an appropriate picture of what is going on at GIFT College and to quantify the elements of the rooftop catchment area. Then other required information is gathered for example hydrological precipitation information and temperature. The volume of water will ascertain thereafter. Water collecting potential for the school will ascertain, and an appropriate plan will be considered. The vital variable of this undertaking is the channel unit which will be planned productive and prudent and possible to carry out in the school. In conclusion, this venture is taken on for preserving the main normal source on the earth. It is a drive to safeguard the water source. "Save Water, automatically Water will save us". Keywords: Rooftop harvesting, channel configuration, rooftop catchment area.
“Modeling of Saline Water Intrusion using MODFLOW in Una Coastal Aquifer of Gujarat, India.”
Authors: Timaniya Aman , Soni Nayankumar
Published: May 2022

Abstract: Groundwater is the most valuable and extensively dispersed resource on the planet, and unlike any other mineral resource, it is replenished annually by meteoric precipitation. The present study would include simulation and modelling of the problem of seawater intrusion in the Una coastal area of Gujarat. The interrelationships of two miscible fluids in porous media have been widely explored both theoretically and experimentally. Because of the extreme salinity, many agricultural wells are no longer used. This high salinity is a sign of a process known as saltwater intrusion, which occurs mostly in coastal aquifers due to excessive pumping. Modelling software has also been utilized to analyze the behavior of groundwater flow models. Numerical models may simulate diverse groundwater scenarios and link them to groundwater management. To simulate seawater intrusion, MODFLOW-2005, a grid-based variable density-dependent flow model, is used. Water balance research reveals that rainwater recharge is the aquifer's primary input. To compute the water level in the area and estimate the position of the seawater intrusion barrier, the saltwater intrusion phenomena were simulated using the MODFLOW software combined with the SWI2 package. The model was used to visualize the salinity levels of the coastal aquifer's groundwater and their fluctuation over time and space from May 2004 to October 2014. The model was developed for a 10-year stress period with 100-time steps, which included a 5-year steady state and 5 years transient state stress period using the previous 10 years of pre-monsoon and postmonsoon data. This research would assist to describe Pumping's impact on groundwater levels and seawater intrusion was studied. Keywords: MODFLOW, Saltwater Intrusion, Modelling, Numerical Model, Coastal aquifer
Conciencia ambiental y actitudes proambientales en estudiantes de educación secundaria de Madre de Dios, Perú
Authors: Estrada Araoz Edwin Gustavo , Huaypar Loayza Karl Herbert , Gallegos Ramos Néstor Antonio , Velasquez Giersch Libertad
Published: May 2022

Actualmente, la educación ambiental viene siendo una estrategia para incrementar la sensibilización de la comunidad educativa sobre el ambiente y la problemática asociada principalmente a la contaminación y depredación. En ese sentido, el objetivo de la presente investigación fue determinar la relación que existe entre la conciencia ambiental y las actitudes proambientales de los estudiantes del nivel de educación secundaria de la Institución Educativa Almirante Miguel Grau Seminario de Madre de Dios, Perú. El enfoque fue cuantitativo, el diseño no experimental y el tipo, descriptivo – correlacional transeccional. La muestra estuvo conformada por 181 estudiantes a quienes se les aplicó el Cuestionario de Conciencia Ambiental y la Escala de Actitudes Proambientales, instrumentos con adecuados niveles de validez y confiabilidad. Según los resultados, el coeficiente de correlación Rho de Spearman entre las variables conciencia ambiental y actitudes proambientales fue de 0,685 (p<0,05). Por ello, se concluyó que existe una relación directa y significativa entre ambas variables de estudio, por lo que resulta imperativo que la institución educativa promueva una educación ambiental partiendo de situaciones cotidianas y articule aspectos teóricos y prácticos en las sesiones de aprendizaje para promover una mayor concientización, preocupación y práctica de conductas ambientales en los actores educativos.
Registros documentados del Vuelvepiedras Rojizo (Arenaria interpres Linnaeus, 1758; Aves: Charadriiformes) en Loreto, Perú
Authors: Torres-Vásquez María Isabel , Angulo Fernando , Garcia-Solsol Luis Armando , Díaz Alván Juan
Published: May 2022

El Vuelvepiedras Rojizo (Arenaria interpres) es una migrante boreal bastante común en playas arenosas y zonas rocosas, en la costa del Perú. Documentamos la presencia de A. interpres en el departamento Loreto, en la Amazonía de Perú, con lo cual se amplía su registro documentado en Perú. Adicionalmente, se proporciona algunos datos sobre su comportamiento, número de individuos y periodo de residencia.
Registros documentados del Colibrí Garganta de Oro de Cola Verde (Polytmus theresiae, Da Silva Maia, 1843; Aves: Trochilidae) en el departamento de Loreto y Ucayali en Amazonía peruana
Authors: Vásquez-Arévalo Francisco Alción , Velasquez Ruiz Estrella , Zegarra Joseph
Published: May 2022

En el Perú el colibrí Polytmus theresiae se distribuye de manera discontinua en pocas localidades tanto al Norte como al Sur. En la presente nota describimos el registro de P. theresiae en nuevas localidades de Amazonía peruana, en los departamentos Loreto y Ucayali.
Perbandingan Algoritma Naïve Bayes, K-Nearest Neighbors dan Random Forest untuk Klasifikasi Sentimen Terhadap BPJS Kesehatan pada Media Twitter
Authors: A.M Tamrizal , Yaqin Ainul
Published: May 2022

Dari sejak didirikan, BPJS terus berusaha meningkatkan kualitas pelayanan termasuk menyediakan berbagai layanan pengaduan. Selain fasilitas pengaduan yang telah disediakan oleh BPJS, media sosial seperti twitter sebenarnya dapat dijadikan sebagai tempat untuk mengumpulkan informasi yang berkaitan dengan BPJS. Berbagai keluhan maupun apresiasi terhadap pelayanan BPJS sering disuarakan melalui media twitter. Pada penelitian ini, dilakukan pengujian tiga algoritma machine learning yaitu Naïve Bayes, K-Nearest Neighbors dan Random Forest, untuk mengetahui dan membandingkan tingkat akurasi dari masing-masing algoritma tersebut dalam melakukan klasifikasi terhadap sentimen masyarakat terhadap BPJS Kesehatan melalui media twitter. Pada penelitian ini dataset diperoleh dengan melakukan scrapping menggunakan twitter API. Data yang diperoleh kemudian diseleksi dan dilakukan labeling. Dari hasil seleksi dan labeling didapatkan dataset sebanyak 150 tweet yang terdiri atas 50 tweet positif, 50 tweet negative dan 50 tweet netral yang akan digunakan dalam percobaan. Pada percobaan dengan menggunakan 90% data untuk training dan 10% data untuk testing, didapatkan tingkat akurasi sebesar 80% Naive Bayes, 67% K-Nearest Neighbors dan 87% Random Forest.
Analisa Fourier Broadband Forecasting Jaringan Telekomunikasi di Indonesia dalam menyambut Visi Indonesia 2045
Authors: Ramadona Suci , Ahdan Syaiful , Rahayu Maya
Published: May 2022

Berdasarkan data APJII (Asosiasi Penyelenggara Jasa Internet Indonesia di tahun 2020, terdapat 73.7% dari populasi Indonesia telah menggunakan jaringan broadband. Pertumbuhan jumlah pengguna layanan broadband ini akan mempengaruhi visi Indonesia Emas 2045. Dimana di dalam visi 2045 tersebut dipaparkan bahwa aspek TIK (Teknologi Informasi Komunikasi) akan terintegrasi di segala bidang, terutama aspek ekonomi dan pemeritahan. Demi tercapainya Indonesia Emas 2045 dan agar semakin baiknya tingkat kepuasan pelanggan, maka pemerintah dan penyedia jasa dirasa perlu menyediakan layanan yang mumpuni. Research ini menyajikan jumlah pengguna jaringan mobile dan fixed broadband, serta harga paket data di Indonesia dalam bentuk Forcasting Analisa Fourier hingga di tahun 2045. Dimana metodologi yang digunakan adalah dengan mengumpulan data jumlah pengguna 2011-2020  dan tren harga paket dari tahun 2008-2020 lalu dilakukannya proses forcasting menggunakan Analisa Fourier, kemudian data validasi dilakukan di tahun 2019-2020. Teknik forcasting menggunakan Analisa Fourier dinyatakan cukup baik dengan estimasi error forecasting kurang dari 8%.
Modelo de aprendizaje desarrollador de la informática para la secundaria básica cubana
Authors: González-Hernández Walfredo
Published: May 2022

El estudio del aprendizaje de la informática es de vital importancia a partir del interés por desarrollar tecnologías de la información para satisfacer las necesidades de cada país. Cada subsistema de educación cubana debe contribuir al aprendizaje de determinados contenidos informáticos y, por ello, es importante, como objetivo de este estudio bibliográfico, descriptivo y exploratorio, elaborar un modelo que propicie el aprendizaje desarrollador de la informática para los contenidos de la secundaria básica. En un primer momento se fundamenta la concepción de aprendizaje desarrollador desde la teoría de la subjetividad. Luego, se obtiene la estructura del modelo compuesto por el contexto socio histórico de surgimiento del modelo, fundamentos filosóficos, psicológicos, didácticos e informáticos, los conceptos fundamentales, el sistema de comunicación, los contenidos informáticos del subsistema, las estrategias de enseñanza, los dispositivos de evaluación y las formas de implementación.
Degradación ambiental y riesgo de desastres en la ciudad de Pereira
Authors: Vásquez Héctor Jaime
Published: May 2022

Desde la perspectiva de las Ciencias Ambientales, entender los riesgos de desastres se soporta sobre la base del conocimiento de las dinámicas territoriales, en particular las transformaciones ambientales históricas. El uso de sensores remotos y cartografía multitemporal permitió describir el proceso de crecimiento de la Ciudad de Pereira, los procesos de degradación ambiental y la configuración de condiciones de riesgo. A partir del trabajo de campo y las investigaciones documentales en contexto histórico, se determinaron escenarios de riesgo relacionados con los fenómenos de mayor relevancia en el territorio: las inundaciones, avenidas torrenciales, fenómenos de remoción en masa y actividad sísmica; este último, conexo con la generación de riesgos ocultos o invisibles, construidos sobre llenos artificiales y canalizaciones. Las causas se sitúan en factores estructurales determinados por procesos políticos, económicos, sociales y ambientales, lo que le confiere la categoría de problemática ambiental. El resultado, es una Ciudad con un gran acumulado de riesgos de desastres, lo que la hace, desde la perspectiva del desarrollo territorial, física y económicamente insostenible, social y ambientalmente insustentable.