bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplikasi Penjualan Baju Berbasis Web (E-Commerce) dengan Formulasi Penyusunan Kode
Authors: Widiana Siska Ayu , Sintaro Sanriomi , Arundaa Rillya , Alfonsius Eric , Lapihu Dodisutarma
Published: December 2022

Perdagangan elektronik atau lebih di kenal sebagai E-commerce adalah konsep yang dapat di gambarkan untuk menggambarkan proses penjualan dan pembelian jasa melalui internet dan dapat menggunakan media website. Sistem informasi penyebaran produk dan jasa dapat di publikasikan dengan luas tanpa perlu mengeluarkan biaya yang sangat besar, hal tersebut sangatlah berbanding terbalik pada usaha penjualan baju yang ada pada Cluthar Project. Pada Cluthar Project dimana sistem penjualan di lakukan apabila ada pembeli datang ke toko dan sistem penyampaian informasi produk yang di sediakan masih dalam cakupan yang kecil dimana penyebaran informasi masih menggunakan pamplet hal tersebut sangatlah tidak efisien dan hal tersebut mempengaruhi penjualan pada Cluthar Project. Oleh karena itu penulis melakukan penelitian secara langsung pada Cluthar Project, dengan metode OOP dan perancangan menggunakan UML untuk meneliti permasalahan pada Cluthar Project. Dalam permasalahan yang ada di Cluthar Project dimana penjualan dan pemasaran barang di lakukan masih tidak efisien, oleh karena itu penulis melakukan perancangan aplikasi penjualan berbasis web (e-commerce) pada Cluthar Project menggunakan aplikasi berbasis web dengan bahasa pemograman PHP dan basis data MySQL dimana aplikasi tersebut dapat di gunakan untuk mempermudah penjualan, pembelian dan penyebaran informasi-informasi produk terbaru karena menggunakan formulasi penyusunan kode barang, hal tersebut dilakukan agar Pembeli melakukan transaksi pembelian tanpa harus datang ke toko, dapat melihat produk terbaru Cluthar Project dan Aplikasi tesebut dapat meningkatkan penjualan pada Cluthar Project
Türkistan'dan Kıbrıs'a Önemli Formülistik Sayıların (3,5,7,9 ve 40) Geçiş Dönemleri Bağlamında Değerlendirilmesi
Authors: ÖYKÜN Emine
Published: December 2022

Kültürün en önemli yapı taşı olan gelenek ve görenekler, toplumların devamlılığını sağlaması ve öz değerlerini koruması açısından en temel unsurlardır. Gelenekler, asırlar boyunca değişikliklere uğrasa da öz yapısını kaybetmemiş ve günümüzdeki ritüellerin pratiğini oluşturmuştur. Bunun yanı sıra kültürel değerler, tarih içerisinde birbirleriyle etkileşime girerek büyürler ve günümüzde farklı coğrafyalarda yaşayan ama aynı kökene sahip toplumları ortak paydada birleştirirler. Bu noktadan hareketle bu çalışmada, Kıbrıs Türkleri ile diğer Türklerin çok önemli ortak unsurlarından olan ve temeli, atalarımızın bin yıllarca hüküm sürdüğü Türkistan’a ve ilk dini inanç sistemimiz olan Şamanizm’e dayanan, daha sonra da İslâmiyet ile uyumlanıp sentezlenen üç, beş, yedi, dokuz ve kırk sayıları incelenmiştir.
3,5,7,9 ve 40’ın günümüz gelenek ve inançlarında nasıl yer bulduğu, geçiş dönemleri (doğum, evlenme ve ölüm) çerçevesinde çeşitli ritüel ve uygulamalar üzerinden ortaya konmuştur. Böylelikle birer motif ve sembol olarak işlevselliğini sürdüren bu sayıların dünyadaki Türk toplumları üzerindeki birleştirici gücü gösterilmeye çalışılmıştır.
Tasarımda Yenilik; Grafik Tablet Özelinde Bir İnceleme
Authors: DEMİREL İNAL Elif Arzen , TARLAKAZAN Elif
Published: December 2022

Teknolojinin hızla ilerlemesi ve yazılım programlarındaki gelişmelerle birlikte plastik sanatların pek çok alanında olduğu gibi grafik tasarım alanında da geleneksel tasarım yöntemlerdeki işleyişin arka plana itildiği gözlemlenmektedir. Pek çok tasarımcı ve sanatçı geleneksel yöntemlerle icra ettikleri eserlerin uzun soluklu, masraflı vb. unsurların farkına varıp, bilgisayar teknolojisinde devam eden gelişmeleri ve tasarım kolaylığını görmüş ve eserlerini dijital ortama taşımaya karar vermişlerdir. Böylece eserlerinde zamandan, malzemelerin muhafazasından ve masraftan tasarruf ederken, imkân fazlalığından, sınırsız renk, araç ve doku çeşitliliğinden yararlanabildiklerini görmüşlerdir.

Fotoğrafçılık sektöründe kullanılan film olgusunu kaldıran, matbaa sektöründeki baskı uygulamalarında yaşanan inovasyonlar olmuştur. Dijital değişim keşfi olarak karşımıza çıkan ve günümüzde grafik çizim tableti olarak adlandırılan çizim tabletleri, ilk olarak sketchpad adı verilen ürünle piyasaya sürülmüştür. Araştırmada, nicel araştırma teknikleri arasında yer alan tarama modeli kullanılmış ve ilgili literatür kaynaklarından (video, görsel ve yazın) konu ile ilgili olan kısımlar derlenerek sunulmuştur. Çizim tabletlerinin temelini atmış olan Skecthpad’den başlayarak doğuşu, gelişimi, inovasyon ile birlikte değişim, dönüşüm ve gelişim konuları örneklerle beraber ele alınmıştır. Ardından çizim tabletlerinin grafik tasarım alanına kattığı değer ve kullanılış kolaylığından bahsedilmiştir. Grafik tasarımın tarihinin gelecek dönemleri için öngörü ve tavsiyelerde bulunulmuştur.
EURİPİDES TRAGEDYASINDA METİNLERARASILIK BAĞLAMINDA İKİ YENİDEN YAZMA ÖRNEĞİ: İPHİGENİA TAURİS’TE–HELENA
Authors: ÖZDEMİR Abdullah
Published: December 2022

Metinlerarasılık, her yazarın kendinden önce yazma işini üstlenmiş ustaların eserlerinden edindiklerine kendi metinlerinde açık ya da kapalı bir şekilde yer vermesi olarak tanımlanabilir. Aslında her yazar, yazmaya başlamadan önce etkilendiği, sevdiği yazarı okumakla başlamıştır yazarlık serüvenine. Okudukları onu şekillendirmiş, okuduklarından öğrendiklerini kendi süzgecinden geçirerek üslubunu, izleyeceği rotayı belirlemiştir. Yazın dünyası için yazılmış olan her metin bir başka metnin izlerini taşımaktadır. Metinlerarasılık kavramında sıkça başvurulan Yeniden Yazmak, bir yazarın başka bir yazara ait bir metni, altmetinleştirerek, yeni bir bağlamda, yeni bir okur kitlesi için, yeni işlevlerle, yeni amaçlarla dönüştürerek yeniden yazması işlemidir. Yeniden yazma eyleminin Antik Çağ’dan beri farklı biçimlerde karşımıza çıkan bir eylem olduğu ve bir yazarın bir ana-metni, bir başka yazara ait olan bir alt-metni yeni bir bağlamda, yeni işlevlerle ve yeni bir okur kitlesi için yeniden yazarak dönüştürmesi olduğu söylenebilir. Araştırmada, tarama modellerinden biri olan betimsel tarama modeli kullanılmıştır. Bu bağlamda çalışma, Euripides’in örneklem olarak seçilen İphigenia Tauris’te ve Helena adlı eserleri ile ilgili verileri, literatür taraması yaparak toplamayı ve doküman analizi tekniğiyle elde edilen bulguları karşılaştırarak verilerin analizini yapmayı amaçlamaktadır. Euripides’in söz konusu tragedyalarını yazarken öncülleri olan Homeros ve Heredotos’tan alıntılar yaptığı ve bu alıntılar sayesinde eserlerini efsaneleri yeniden yazma suretiyle oluşturduğu böylelikle geçmiş dönemlere ait sözlü metinleri yeniden yazarak kendi dönemine taşımış olduğu örneklerle saptanmıştır. Sonuç olarak Euripides’in, Metinlerarasılık teriminin kullanılmaya başlandığı 20. yüzyıldan yaklaşık 2500 yıl önce söz konusu kavramı pratikte kullanmış olduğu örnek eserlerden yapılan alıntılarla belirtilmiştir.
Tratamiento informativo del término protocolo en la prensa española
Authors: Salas Blanco Julio , Estanyol Casals Elisenda
Published: December 2022

Este artículo analiza el tratamiento informativo que la prensa española da al término “protocolo” en sus noticias. El estudio está enfocado en comprobar la forma en que se utiliza dicho término por parte de la prensa y si se ajusta a las definiciones teórico-científicas o, por el contrario, si se le otorga otro significado que puede llevar a confusión. Para ello se han analizado las noticias publicadas que contienen la palabra “protocolo” en las ediciones digitales de El País, El Mundo, La Vanguardia y ABC durante los años 2016 y 2017, una muestra conformada por un total de 866 noticias, para identificar si se confunde dicho término con otros que se pueden asemejar al mismo como etiqueta, ceremonial, cortesía o buenas maneras. El análisis se ha complementado con 16 entrevistas en profundidad a académicos y expertos en Protocolo realizadas en 2020. Los resultados muestran, en un porcentaje superior al 50%, que en los medios se suele confundir protocolo con educación social, con gastos banales y otros aspectos que no tienen nada que ver con el protocolo; a veces denostando el término y asociándolo a reglas inquebrantables. Se concluye que la mejora en la conceptualización del término por parte de los medios es necesaria y que, dada la influencia de estos en la generación de opinión pública, ayudaría a un mejor entendimiento de este concepto entre la sociedad.
Ceremonial de la Apertura Estatal del Parlamento del Reino Unido
Authors: Rabasco Ferreira Rafael
Published: December 2022

La apertura estatal del Parlamento del Reino Unido por el monarca en el Palacio de Westminster es uno de los mayores acontecimientos políticos que se viene sucediendo anualmente en la historia de esta nación -salvo excepciones contadas- y marca el comienzo del nuevo año parlamentario. Todo sucede bajo las pautas de un solemne y detallado ceremonial cargado de simbología y tradición, con el que se expresa y trasluce la hegemonía del Estado y su poder soberano a través de la consolidación histórica y relación que han desarrollado sus instituciones fundamentales, como son la monarquía y el parlamento bicameral.
Creatividad, educación y neoliberalismo: propuesta para un modelo de pedagogía crítica
Authors: Martín-Martínez Almudena
Published: December 2022

Los temas que aborda el presente artículo son el uso interesado del término creatividad por parte del neoliberalismo, cómo éste ha influido en las políticas educativas durante los últimos años, si es posible contrarrestar esta influencia y, en tal caso, de qué modo puede plantearse una alternativa en forma de modelo pedagógico crítico. A tal efecto se intenta definir preliminarmente un concepto de creatividad a través de un enfoque multidisciplinar (psicológico, sociológico, antropológico, psicológico…) con una base crítica que se contrapone a las ideas que en las últimas décadas ha acuñado el discurso neoliberal. A la luz de esta contraposición se indaga en el modo en que la pedagogía debe implementar la creatividad para el desarrollo óptimo de la capacidad crítica de los estudiantes, para así plantear un modelo educativo que les permita cuestionarse las estrategias y la finalidad de su propio proceso de aprendizaje, así como formar libremente su propia subjetividad y potenciar su pensamiento crítico. Este recorrido argumental recurre a una metodología basada en la revisión bibliográfica –investigación documental– de las fuentes apropiadas a los conceptos tratados directamente y de modo contextual. Finalmente, se presentan una serie de conclusiones que demuestran la necesidad de plantear un modelo educativo alternativo, resultado de un sistema pedagógico afín, que fomente la creatividad de tal modo que favorezca la generación de procesos de aprendizaje y enseñanza críticos.
Reforzar la implicación educativa entre artes visuales, música y literatura
Authors: Huerta Ricard
Published: December 2022

El volumen que han coordinado las profesoras Carmen Franco-Vázquez, Carol Guillanders y Marta Neira-Rodríguez, nos ofrece una serie de aportaciones elaboradas por profesionales de distintas áreas de conocimiento, como didáctica de la expresión musical, artística, lengua y literatura o filología gallega, con diferentes formaciones. Se trata en su mayoría de miembros del grupo de investigación LITER21. Por tanto, la interdisciplinariedad sería la esencia de estos trabajos en los que coopera personal de varias universidades.El volumen que han coordinado las profesoras Carmen Franco-Vázquez, Carol Guillanders y Marta Neira-Rodríguez, nos ofrece una serie de aportaciones elaboradas por profesionales de distintas áreas de conocimiento, como didáctica de la expresión musical, artística, lengua y literatura o filología gallega, con diferentes formaciones. Se trata en su mayoría de miembros del grupo de investigación LITER21. Por tanto, la interdisciplinariedad sería la esencia de estos trabajos en los que coopera personal de varias universidades.
A Roda da Fortuna nos Dictats de Ausiàs March (c. 1397-1439)
Authors: Da Costa Ricardo , Coimbra Lemke Wilson
Published: December 2022

Resumo:  A alegoria da Roda da Fortuna é um tema recorrente no pensamento medieval, sobretudo na Filosofia e na Literatura. A noção de fortuna foi herdada de uma dupla tradição e adaptada por Ausiàs March (c. 1397-1439) para uso literário. A primeira fonte é antiga: greco-romana. Primeiro, Aristóteles (384-322 a.C.) começou a lhe arranjar um espaço na sua concepção filosófica e política (Física, II, 4-6; Política, V, 3). Depois, Políbio (200-120 a.C.), Tito Lívio (c. 59 a.C. - 17 d.C.) e Plutarco (46 - 120) analisaram sua influência na história. A segunda, medieval, é a da Consolação da Filosofia, de Boécio (c. 477-524). Trataremos dessa alegoria nos Dictats, de Ausiàs March, para mostrar como o poeta valenciano desenvolveu literariamente o tema da instabilidade da Roda da Fortuna em seus poemas.Palavras chave: Ausiàs March, Roda da Fortuna, Literatura.Abstract: The allegory of the Wheel of Fortune is a recurring theme in medieval thought, especially in Philosophy and Literature. The notion of fortune was inherited from a double tradition and adapted by Ausiàs March (c. 1397-1439) for literary use. The first source is ancient: Greco-Roman. First, Aristotle (384-322 BC) began to find a place for it in his philosophical and political conception (Physics, II, 4-6; Politics, V, 3). Afterwards, Polybius (200-120 BC), Livy (c. 59 BC - 17 AD) and Plutarch (46 - 120) analyzed its influence on history. The second, medieval, is the Consolation of Philosophy, by Boethius (c. 477-524). We will deal with this allegory in the Dictats, by Ausiàs March, to show how the Valencian poet literarily developed the theme of the instability of the Wheel of Fortune in his poems.Keywords: Ausiàs March, Wheel of Fortune, Literature.
La riuada del Túria de 1897. Un motiu poètic per als renaixencistes valencians
Authors: Sanchis Mollà Hèctor
Published: December 2022

Resum: Al s. xix, en català, gràcies a les possibilitats que permeté la Renaixença, es composen un conjunt de poemes al voltant dels estralls produïts per distints fenòmens naturals. L’objectiu del present treball és realitzar una aproximació a vuit composicions conreades per distints lletraferits valencians, les quals discorren al voltant del succés que commocionà la ciutat de València el 10 de novembre de 1897, el desbordament del riu Túria.Paraules clau: Renaixença, poesia, València, riuada TúriaAbstract: In the 19th century and, in Catalan, thanks to the possibilities offered by the Renaixença,a set of poems are composed around the devastation caused by different natural phenomena. The aim of this work is to make an approach to eight compositions cultivated by different Valencian lyricists, which revolve around the event that shocked the city of Valencia on Tenth of November of one thousand eight hundred ninety-seven, the overflowing of the Turia river.Keywords: Renaixença; poetry; València; Túria flood.
Orígens i influències culturals de la figura de la Dona d’aigua
Authors: Rocas Sumoy Júlia
Published: December 2022

Resum: Les dones d’aigua són figures de la mitologia catalana que existeixen des dels inicis dels temps i que han anat evolucionant i modificant-se amb el pas dels segles fins a convertir-se en els personatges que avui coneixem. Presenten una gran multiplicitat de formes, noms i funcions als diferents mites que protagonitzen, sempre en relació a les necessitats locals de cada petita societat. En aquest article es pretén dur a terme un estudi sobre els seus orígens i les influències culturals que han rebut en els diferents períodes de la història, des de les mitologies antigues fins a les modernes per tal d’observar les similituds i diferències que hi ha d’una cultura a l’altra i entendre el rol que ocupen en la configuració d’una identitat cultural.Paraules clau: Mitologia, dona d’aigua, català, fada, identitat.Abstract: The dones d’aigua (water women) are figures of Catalan mythology that have existed since the dawn of time and have evolved and changed over the centuries to become the characters we know today. They present a great multiplicity of forms, names and functions to the different roles they play, always in relation to the local needs of each small society. In this article I intend to carry out a study on their origins and the cultural influences they have received in the different periods of history, from the ancient mythologies to the modern ones, in order to observe the similarities and differences from one culture to another and to understand the role they play in the configuration of a cultural identity. Keywords: Mythology, dona d’aigua, catalan, fairy, identity.
Banditi a Orgosolo. Una variante del Banditisme?
Authors: Grilli Giuseppe
Published: December 2022

Riassunto: I presente lavoro parte dell’articolo di una rivista di cui ormai una certa memoria resta, Nuovi Argomenti, dove nel 1954 Franco Cagnetta, pubblicò un’inchiesta sulla realtà sociale della Barbagia, con particolare riferimento alla realtà di Orgosolo stretta tra il disagio di una economia di pastorizia e la sua costante deriva nel sistema delle faide e del banditismo. Ora si fa una nuova lettura.Parole chiave: Sardegna, banditismo, Franco Cagnetta, Orgoloso.Abstract: The present work is based on an article by Franco Cagnetta, published in Nuovi Argomenti, in 1954. That essay contained a survey on the social reality of Barbagia, and in particular on Orgosolo. The data came from a study of the pastoral economy and its drift towards banditry. Now, a new reading is done.Keywords: Sardinia, banditry, Franco Cagnetta, Orgoloso.
Application of Testing Machine PIB Technology in Intelligent Hardware-Assisted College Sports Remote Training System
Authors: Wang Xiao
Published: December 2022

This paper firstly analyzes the characteristics of testing machine PIB from the technical level, and analyzes the role of PIB technology in college sports remote training. First, it discusses an intelligent in-machine testing PIB verification system. The remote software/hardware faults are injected into the system under test to verify the validity of the PIB design. Then combine React and Angular frameworks to establish the front and back systems of the college sports remote training system to visualize sports data, use PIB hardware for sports data entry, and combine hardware and software to assist the perfect operation of the college sports remote training system, with a real-time efficiency of 97%.
Compreensão dos Padrões de Comportamento Organizacional em direção a Sustentabilidade a partir da Perspectiva Neoinstitucional
Authors: Faria Emília de Oliveira , Marques Gilmar dos Santos , Silveira Tatiana Rodrigues
Published: December 2022

O presente estudo pretendeu apresentar uma discussão teórica a partir dos pressupostos da abordagem neoinstitucionalista, de modo a contribuir para uma melhor compreensão do comportamento das organizações diante das novas demandas sociais, em especial, da sustentabilidade. Além disso, também foi realizada uma revisão sistemática da literatura nacional com o intuito de mapear os artigos publicados no Brasil que discorrem sobre as mudanças organizacionais relacionadas à sustentabilidade e às suas principais influências. Os principais achados da revisão sistemática foram: existem poucos estudos sobre os instrumentos proativos/voluntários utilizados pelas empresas; embora não haja uma especificação quanto ao uso da Teoria Neoinstitucional no referencial teórico dos artigos, as variáveis apontadas estão diretamente ligadas ao framework da NEI; há uma crescente homogeneização do comportamento das organizações no que diz respeito aos relatórios de sustentabilidade e sua divulgação; as atividades extrativas, devido ao seu grande impacto, estão preocupadas com questões ambientais e se mostram engajadas com processos de certificação ambiental; e por fim, os processos isomórficos têm sido evidenciados em vários segmentos do mercado no que se refere às práticas sustentáveis.
Удивительные циклиды — свидетели Великого пермского вымирания. Часть 2, "Природа"
Authors: Мычко Э.В.
Published: December 2022

Циклиды — группа вымерших ракообразных, остающаяся загадочной из-за редкости их ископаемых остатков. Они существовали как в бассейнах с различной соленостью, так и в пресных водоемах. Циклиды были компонентами рифов и селились на морском дне, бедном жизнью. Не известны ни их предки, ни причины их вымирания. Морфотип циклид позволяет рассматривать их происхождение по аналогии с процессом появления крабов от омароподобных предков и на этом основании предположить, как могла выглядеть их предковая форма.
«…Сосны здесь почти что сходятся с тропической растительностью». Из дневника Ф.Г.Добржанского 1935 г. Мексика. Часть 2, "Природа"
Authors: Конашев М.Б.
Published: December 2022

Окончание публикации дневниковых записей Ф.Г.Добржанского — выдающегося российско-американского генетика, эволюциониста, энтомолога, — сделанных летом 1935 г., во время поездки в Мексику с целью изучения генетической изменчивости в природных популяциях плодовой мушки Drosophila pseudoobscura и определения ее ареала.
In vitro and In vivo Evaluation of Fungicides, against Colletotrichum lindemuthianum Causing Anthracnose of Mungbean
Authors: Patil Vishal , Choudhary A. K. , Lekharam . , Kumawat Harsh
Published: December 2022

Mungbean [Vigna radiata (L.) Wilczek] is a popular pulse crop, second only to chickpea and pigeon pea, and is grown in many parts of the world. Mungbean belongs to family Leguminosae. In the suitable condition bean is attacked by various diseases. Out of which, anthracnose caused by seed borne pathogen Colletotrichum lindemuthianum is an important fungal disease and major limiting factor for yield loss. Realizing the potentiality of the disease in causing economic losses, the different fungicides are tested against Colletotrichum lindemuthianum among the fungicides Difenoconazole 25% EC, Carbendazim 50% WP, Metiram 70% WG, Propiconazole 25% EC, Pyraclostrobin 20% WP Propineb 70% WP, Carbendazim 12% WP+ Mancozeb 63% WP, Hexaconazole 5% EC respectively.
Performance of CdS/TNTAs Nanocomposite in Removing Ciprofloxacin and Hydrogen Production using Simultaneously Electrocoagulation-Photocatalysis Process
Authors: Sugihartini Rahayu Lestari , Pratiwi Reno , Slamet Slamet
Published: December 2022

This study used CdS as a pair of TiO2 Nanotube Arrays (TNTAs), considering the position and width of the energy band gap, which is expected to increase photocatalyst performance. The nancomposite was synthesized using the successive ionic layer adsorption reaction (SILAR) method, with Cd(CH3COO)2 and Na2S as precursors. The CdS/TNTAs nanocomposite is expected to reduce the energy band gap to enable the visible and UV spectrum to activate the photocatalyst. Additionally, the formed heterojunction mechanism provides opportunities for the trajectories of electrons and holes to be farther apart and reduce the recombination rate. The degradation ability of CdS/TNTAs nanocomposite in the photocatalytic process was evaluated using samples of ciprofloxacin liquid waste as an antibiotic, which is quite challenging to decompose completely. The ability of the photocatalytic process to produce hydrogen gas was also observed and its performance synergized with the electrocoagulation process. The result showed that the use of CdS as a TNTAs partner in CdS/TNTAs nanocomposites affects increasing photocatalyst performance, both in degrading ciprofloxacin and producing hydrogen gas. Furthermore, the CdS/TNTAs nanocomposite increased the photocatalytic process’s ability to degrade ciprofloxacin and produce hydrogen from 8.5 to 20.5% and 6 to 23.5 mmol/m2 compared to using TNTAs alone. The processing capability is further enhanced when run in synergy with the electrocoagulation process where the removal of ciprofloxacin reaches 86.55%  and the hydrogen produced is 2.62×106 mmol/m2. Copyright © 2022 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Extending the EclipseTM AcurosXB output factor table for small field radiosurgery
Authors: Wu Ning Genevieve
Published: December 2022

Purpose

To investigate the necessity of extending the output factor table (OF Table) of the Varian EclipseTM Treatment Planning System for small field stereotactic radiosurgery (SRS) and stereotactic body radiosurgery (SBRT) treatments.

Methods

A new AcurosXB 15.6 beam model was created in the Eclipse Beam Configuration, which is identical to the one that has been used in the clinic with a default 3 × 3 cm to 40 × 40 cm OF Table, except the OF Table in the new model was extended to cover the range from 1 × 1 cm to 40 × 40 cm. 80 small square and rectangular output factors were measured on a Varian TrueBeam utilizing a Standard Imaging Exradin W2‐1×1 scintillator detector, inside a PTW BeamScan water tank with 95 cm SSD at 5 cm depth. Cerenkov contamination was corrected using a rectangular field method (2 cm × 15 cm field). Nine Radiosurgery plans with primary jaw setting ranging from 0.7 cm to 2.0 cm were evaluated by both beam models. The monitor unit (MU) differences between the two beam models were calculated for identical 3‐dimensional (3D) absolute dose distributions. Output factors, measured versus Eclipse calculated, were compared down to 0.5 × 0.5 cm primary jaw setting.

Results

For the 6FFF beam, the difference between the two beam models was ∼ 6% for 1 × 1 cm jaw settings and 4% at 1.5 × 1.5 cm, with the extended OF Table requiring higher MUs for the same dose prescription and same 3‐dimensional isodose distribution. For the 6MV beam, the corresponding difference is ∼7.5% for 1 × 1 cm, 5% for 1.5 × 1.5 cm, and 3% for 2 × 2 cm jaw settings, with the extended OF Table requiring higher MUs. For jaw settings smaller than 1 × 1 cm, measured dose can be considerably smaller than Eclipse predicted dose, even with the OF Table extension. This is reflected by the fact that the output factor for 0.5 × 0.5 cm, calculated via Eclipse external beam, was more than 30% greater than that measured for both 6FFF and 6MV beams.

Conclusions

Eclipse does a satisfactory job for primary jaw sizes down to 2 cm. For jaw settings smaller than 1.5 cm, the OF Table in Eclipse should be extended to improve the dose calculation accuracy.
Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies
Authors: O'Halloran Seán , Pandit Abhay , Heise Andreas , Kellett Andrew
Published: December 2022

Two‐photon polymerization (TPP) has become a premier state‐of‐the‐art method for microscale fabrication of bespoke polymeric devices and surfaces. With applications ranging from the production of optical, drug delivery, tissue engineering, and microfluidic devices, TPP has grown immensely in the past two decades. Significantly, the field has expanded from standard acrylate‐ and epoxy‐based photoresists to custom formulated monomers designed to change the hydrophilicity, surface chemistry, mechanical properties, and more of the resulting structures. This review explains the essentials of TPP, from its initial conception through to standard operating principles and advanced chemical modification strategies for TPP materials. At the outset, the fundamental chemistries of radical and cationic polymerization are described, along with strategies used to tailor mechanical and functional properties. This review then describes TPP systems and introduces an array of commonly used photoresists including hard polyacrylic resins, soft hydrogel acrylic esters, epoxides, and organic/inorganic hybrid materials. Specific examples of each class—including chemically modified photoresists—are described to inform the understanding of their applications to the fields of tissue‐engineering scaffolds, micromedical, optical, and drug delivery devices.
On the true nature of the contact binary CRTS J192848.7‐404555
Authors: Wadhwa Surjit S. , DeHorta Ain Y. , Filipović Miroslav , Tothill Nick F. H.
Published: December 2022

CRTS J192848.7‐404555 was recognized as a potential contact binary merger candidate on the basis of survey photometry analysis. We have carried out follow‐up ground‐based photometry of the system and showed that at the recorded coordinates for the system, there are two stars approximately 3 s of arc apart. Our analysis shows that the fainter of the two stars is the actual variable while the slightly brighter star is of fixed brightness. In addition, we show that the reported survey photometry is the result of both stars being treated as a single light source with resultant erroneous light curve solution. The true nature of CRTS J192848.7‐404555 shows it to be a low mass contact binary system with a high mass ratio of 0.425, high amplitude of 0.69 magnitude, and shallow 24% contact. The system does not have features of orbital instability and is not a potential merger progenitor.
Synthesis, characterization, and electrocatalytic behaviour of hydrothermally grown nanostructured La2O3 and La2O3/K‐complex
Authors: Srivastava Ankur , Mishra Gargi , Singh Kshitij RB , Singh Jay , Pandey Rampal , Pandey Mrituanjay D.
Published: December 2022

Rare earth metals play a conspicuous role in magnetic resonance imaging (MRI) for detecting cancerous cells. The alkali metal potassium is a neurotransmitter in the sodium–potassium pump in biomedical sciences. This unique property of rare earth metals and potassium drew our attention to carry forward this study. Therefore, in this work, previously synthesized potassium (K) complexes formed by the reflux of 4‐N,N‐dimethylaminobenzoic acid (DBA) and potassium hydroxide in methanol, and named [(μ2–4‐N,N‐dimethylaminobenzoate‐κO)(μ2–4‐N,N‐dimethylaminobenzoic acid‐κO)(4‐N,N‐dimethylaminobenzoic acid‐κO) potassium(I) coordination polymer)] were treated hydrothermally with La2O3 nanomaterials to obtain a nanohybrid La2O3/K‐complex. After that, the K‐complex was analyzed using single‐crystal X‐ray diffraction and 1H and 13C NMR spectroscopy. In addition, the structural and morphological properties of the as‐prepared nanostructured La2O3/K‐complex were also characterized, which involved an investigation using X‐ray diffraction (XRD)spectroscopy, Fourier transform infrared (FTIR) spectroscopy, atomic force spectroscopy (AFM), transmission electron microscopy (TEM), and energy dispersive X‐ray (EDX) analysis. After this, the electrochemical redox behaviour of the synthesized nanohybrid material was studied using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Therefore, the results from these studies revealed that the as‐prepared material was a La2O3/K‐complex that has a promising future role in sensing various analytes, as it showed effective electrocatalytic behaviour.
Redox‐metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation
Authors: Zakic Tamara , Stojanovic Sara , Jankovic Aleksandra , Korac Aleksandra , Pekovic‐Vaughan Vanja , Korac Bato
Published: December 2022

Adaptive responses to environmental and physiological challenges, including exposure to low environmental temperature, require extensive structural, redox, and metabolic reprogramming. Detailed molecular mechanisms of such processes in the skin are lacking, especially the role of nuclear factor erythroid 2‐related factor 2 (Nrf2) and other closely related redox‐sensitive transcription factors Nrf1, Nrf3, and nuclear respiratory factor (NRF1). To investigate the role of Nrf2, we examined redox and metabolic responses in the skin of wild‐type (WT) mice and mice lacking functional Nrf2 (Nrf2 KO) at room (RT, 24 ± 1°C) and cold (4 ± 1°C) temperature. Our results demonstrate distinct expression profiles of major enzymes involved in antioxidant defense and key metabolic and mitochondrial pathways in the skin, depending on the functional Nrf2 and/or cold stimulus. Nrf2 KO mice at RT displayed profound alterations in redox, mitochondrial and metabolic responses, generally akin to cold‐induced skin responses in WT mice. Immunohistochemical analyses of skin cell compartments (keratinocytes, fibroblasts, hair follicle, and sebaceous gland) and spatial locations (nucleus and cytoplasm) revealed synergistic interactions between members of the Nrf transcription factor family as part of redox‐metabolic reprogramming in WT mice upon cold acclimation. In contrast, Nrf2 KO mice at RT showed loss of NRF1 expression and a compensatory activation of Nrf1/Nrf3, which was abolished upon cold, concomitant with blunted redox‐metabolic responses. These data show for the first time a novel role for Nrf2 in skin physiology in response to low environmental temperature, with important implications in human connective tissue diseases with altered thermogenic responses.
Bulky anion effect on the architecture of chiral dysprosium single‐molecule magnets
Authors: Douib Haiet , Dhbaibi Kais , Lefeuvre Bertrand , Dorcet Vincent , Guizouarn Thierry , Pointillart Fabrice
Published: December 2022

The interest for chiral tris(β‐diketonato)lanthanide complexes in coordination chemistry is huge due to its Lewis acid character, optical activity, and the control of the final compound architecture. The reaction of equimolar quantities of [Dy((−)/(+)hfc)3(H2O)] (hfc− = 3‐(heptafluoropropylhydroxymethylene)‐(+/−)‐camphorate) and L led to the formation of a pair of enantiomers for dinuclear complexes [Dy((−)/(+)hfc)3(L)]2⋅C7H16 ([(−)/(+)1]⋅C7H16) (L = 4′‐(4′′′‐pyridyl‐N‐oxide)‐1,2′:6′1′′‐bis‐(pyrazolyl)pyridine]). Starting from the previous experimental protocol with the addition of bulky BArF anions, a partial dissociation of the chiral [Dy((−)/(+)hfc)3(H2O)] was observed leading to the isolation of a mono‐dimensional cationic chiral polymer {[Dy((−)/(+)hfc)2(L)][BarF]}n⋅nCH3NO2 ([(−)/(+)2]n⋅nCH3NO2). Natural circular dichroism (NCD) highlighted an exciton CD couplet for [(−)/(+)2]n but not for (−)/(+)1. The latter behaves as a single‐molecule magnet (SMM) with a blocking temperature up to 4 K, whereas [(−)/(+)2]n is a 1D assembly of field‐induced SMMs with a magnetic relaxation occurring through a Raman process only.
The zonal patterns in late Quaternary South American Monsoon precipitation
Authors: Kukla Tyler , Winnick Matthew , Laguë Marysa , Xia Zhengyu
Published: December 2022

Speleothem oxygen isotope records (δ18O) of tropical South American
rainfall in the late Quaternary show a zonal “South American
Precipitation Dipole” (SAPD). The dipole is characterized by opposing
east-west precipitation anomalies compared to the present—wetter in
the east and drier in the west at the mid-Holocene (∼7 ka), and drier in
the east and wetter in the west at the Last Glacial Maximum (LGM; ∼21
ka). However, the SAPD remains enigmatic because it is expressed
differently in western versus eastern δ18O records and isotope-enabled
climate model simulations usually misrepresent the magnitude and/or
spatial pattern of δ18O change. Here, we address the SAPD enigma in two
parts. First, we re-interpret the δ18O data to account for upwind
rainout effects that are known to be pervasive in tropical South
America, but are not always considered in Quaternary paleoclimate
studies. Our revised interpretation reconciles the δ18O data with cave
infiltration and other proxy records, and indicates that the centroid of
tropical South American rainfall has migrated zonally over time. Second,
using an energy balance model of tropical atmospheric circulation, we
hypothesize that zonal migration of the precipitation centroid can be
explained by regional energy budget shifts, such as changing Saharan
albedo associated with the African Humid Period, that have not been
modeled in previous SAPD studies. This hypothesis of a migrating
precipitation centroid presents a new framework for interpreting δ18O
records from tropical South America and may help explain the zonal
rainfall anomalies that predate the late Quaternary.
Design and characterization of lipid nanocarriers for oral delivery of immunotherapeutic peptides
Authors: Calderón‐Colón Xiomara , Zhang Yichuan , Tiburzi Olivia , Wang Jialu , Hou Shenda , Raimondi Giorgio , Patrone Julia
Published: December 2022

The use of therapeutic proteins and peptides is of great interest for the treatment of many diseases, and advances in nanotechnology offer a path toward their stable delivery via preferred routes of administration. In this study, we sought to design and formulate a nanostructured lipid carrier (NLC) containing a nominal antigen (insulin peptide) for oral delivery. We utilized the design of experiments (DOE) statistical method to determine the dependencies of formulation variables on physicochemical particle characteristics including particle size, polydispersity (PDI), melting point, and latent heat of melting. The particles were determined to be non‐toxic in vitro, readily taken up by primary immune cells, and found to accumulate in regional lymph nodes following oral administration. We believe that this platform technology could be broadly useful for the treatment of autoimmune diseases by supporting the development of oral delivery‐based antigen specific immunotherapies.
Correlation of the degenerative stage of a disc with magnetic resonance imaging, chemical content, and biomechanical properties of the nucleus pulposus
Authors: Azril  , Huang Kuo‐Yuan , Hobley Jonathan , Rouhani Mehdi , Liu Wen‐Lung , Jeng Yeau‐Ren
Published: December 2022

Intervertebral disc degeneration (IDD) is closely related to changes in the intervertebral disc (IVD) composition and the resulting viscoelastic properties. IDD is a severe condition because it decreases the disc's ability to resist mechanical loads. Our research aims to understand IDD at the cellular level, specifically the changes in the viscoelastic properties of the nucleus pulposus (NP), which are poorly understood. This study employed a system integrating nanoindentation with Raman spectrometry to correlate biomechanics with subtle changes in the biochemical makeup of the NP. The characterization was, in turn, correlated with the degenerative severity of IVD as assessed using magnetic resonance imaging (MRI) of different patients with spinal stenosis, degenerative spondylolisthesis, and degenerative scoliosis. It is shown that there is an increase in the crosslinking ratio in collagen, a reduction in proteoglycan, and a build‐up of minerals upon the rise in the severity level of the disc damage in the NP. Assessment of mechanical characteristics reveals that the increasing disc degeneration makes the NP lose its elasticity, becoming more viscous. This shows that the tissue undergoes abnormalities in weight‐bearing ability, which contributes to spinal instability. The correlation of the individual discs shows that grades III and IV have similarities in the changes of Amide I and III toward the storage modulus. In contrast, grades IV and V correlate with mineralization toward the storage modulus. Reduction of proteoglycan has the highest impact on the changes of the storage modulus in all grades of IDD. Connecting compositional alterations to IVD micromechanics at various degrees of degeneration expands our understanding of tissue behavior and provides critical insight into clinical diagnostics, treatment, and tissue engineering.
Professionalism and professional identity formation in dental students: Revisiting the professional role orientation inventory (PROI)
Authors: Smith Carlos S. , Stilianoudakis Spiro C. , Carrico Caroline K.
Published: December 2022

Objective

Professionalism is a hallmark of health professions education. Professional identity formation is a growing field of exploration in medical education, and the dental literature is sparse on just how professional identity formation is developed and assessed within dental education.

Methods

The validated professional role orientation inventory (PROI) was administered to 2nd year dental students during a spring semester ethics course. The PROI includes four 10‐item scales representing four attitudinal factors: Authority, Responsibility, Agency, and Autonomy.

Results

When compared to a historical sample of dental students in the early 1990s, dental students today scored significantly higher on Responsibility (p = 0.0309) and lower on the Agency factor (p = 0.0001). Authority scores in the current sample of dental students were significantly associated with age and race, with an increase in age associated with a decrease in Authority (p = 0.0504) and Caucasian respondents demonstrating significantly higher scores than Asian or Other races. Debt was associated with differences in Autonomy (p = 0.0683) and Agency (p = 0.0106), with those in the 100k–300k anticipated debt range demonstrating lower levels of both Autonomy and Agency. Race was marginally associated with Responsibility with those in the Other race category (Hispanic, Black/African American, Other/Multiracial) demonstrating higher levels than Caucasian (p = 0.0513).

Conclusion

Dental students' scores denote a continued commitment to others yet a feeling of less sense of control as a practicing professional. A redefining of professionalism to include social activism and advancing health equity is required given their altruism and commitment to others, which remains high.
Impact of peri‐implantitis on the proteome biology of crevicular fluid: A pilot study
Authors: Halstenbach Tim , Nelson Katja , Iglhaut Gerhard , Schilling Oliver , Fretwurst Tobias
Published: December 2022

Background

The proteome of the peri‐implant crevicular fluid (PICF) has not been systematically investigated. The aim of the present study was to reveal the proteome biology of dental implants affected with peri‐implantitis.

Methods

Patients with at least one diseased implant were included (probing depth ≥6 mm, ≥3 mm peri‐implant radiological bone loss). Using sterile paper strips, samples were collected from healthy implants (I), healthy teeth (T) and peri‐implantitis affected implants (P). Proteome analysis was performed using liquid chromatography — tandem mass spectrometry (LC‐MS/MS) and data independent acquisition, allowing the identification and quantification of human and bacterial proteins as well as semi‐specific peptides.

Results

A total of 38 samples from 14 patients were included in the study; 2332 different human proteins were identified across all samples. No differentially expressed proteins between T and I were found. Comparing P to I, 59 proteins were found upregulated and 31 downregulated in P with significance. Upregulated proteins included proinflammatory proteins such as immunoglobulins, dysferlin, and S100P, as well as antimicrobial proteins, for example, myeloperoxidase or azurocidin. Gene ontology analysis further revealed higher activity of immunological pathways. Proteolytic patterns indicated the activity of inflammatory proteins such as cathepsin G. A total of 334 bacterial proteins were identified and quantified. Peri‐implantitis showed elevated proteolytic activity.

Conclusion

I and T share similarities in their proteome, while diseased implants deviate strongly from healthy conditions. The PICF proteome of peri‐implantitis affected sites exhibits an inflammatory fingerprint, dominated by neutrophil activity when compared with healthy implants.
Technical note: Multi‐receiver combination method for phase‐based electrical property tomography of the breast
Authors: Kim Jun‐Hyeong , Shin Jaewook , Jung Kyu‐Jin , Cui Chuanjiang , Kim Soo‐Yeon , Lee Jae‐Hun , Kim Dong‐Hyun
Published: December 2022

Background

Phase‐based electrical property tomography (EPT) is a technique that allows conductivity reconstruction with only phase of the B1 field under the assumption that the magnitude of the B1 fields are homogeneous. The more this assumption is violated, the less accurate the reconstructed conductivity. Thus, a method that ensures homogeneity of field is important for breast image using multi‐receiver coil.

Purpose

To develop a method for multi‐receiver combination for phase‐based EPT usable for breast EPT imaging in the clinic.

Methods

Theory of the proposed method is presented. To validate the proposed method, the phantom and in‐vivo experiments were conducted. Conductivity images were reconstructed using the transceive phase of the combined image and results were compared with another combination method.

Results

The proposed method's conductivity results were more stable than those of the previous method when was not homogeneous and when the homogeneous contrast region was small. The phantom and in‐vivo results indicate that the proposed method produces improved conductivity images than the previous method. The proposed combination method also increased the conductivity contrast between benign and cancerous tissues.

Conclusion

The proposed method produced more stable multi‐receiver combination for phase‐based EPT of the breast in a clinical environment.
Spillovers impact of institutional and economic factors in energy intensity
Authors: Alvarado Rafael , Ortiz Cristian , Cuesta Lizeth , Tillaguango Brayan
Published: December 2022

Previous literature does not incorporate the spillover effects of institutional factors in the analysis of the determinants of energy intensity. This research aims to empirically examine the impact of institutional and economic factors on energy intensity using spatial panel data models. Specifically, the institutional factors included are civil liberties, political corruption, and women's political empowerment. We find robust evidence that there are spillover effects from regressors on the energy intensity of countries. We find that the index of civil liberties, political corruption, and women's political empowerment reduce energy intensity. In addition, we find robust evidence that real output per capita and oil price reduce energy intensity, while manufacturing industry increase it. Our results indicate that manufacturing activity requires greater attention from policymakers and academics to mitigate the harmful aspects of energy intensity. Likewise, our results constitute a new look at the approach to mechanisms to reduce energy intensity to achieve sustainable economic development consistent with Sustainable Development Goals 7 and 12.
Structural assessment of prestressed beams with natural corrosion
Authors: Coronelli Dario , Mircea Calin , Rogers Rhys , Rosati Gianpaolo , Consiglio Andrea Nino
Published: December 2022

An experimental campaign carried out on prestressed bridge beams corroded in a marine environment is analyzed in order to understand the failure modes related to the deterioration phenomena and setup models for capacity assessment. Three main failures modes were identified: shear in the web, shear failure in corroded zones with prestress loss and flexural failure for corroded strands in tension; this last mode becomes dominant for increasing corrosion. A truss model was used for flexure and shear resistance, considering the presence of both bottom pretensioned strands breaks and a draped post‐tensioned tendon cuts. The development of new anchorage at the sides of the damaged zones of the strands was modeled. Corrosion effects are modeled reducing the reinforcement cross‐section and bond, and modifying the prestressing distribution and the truss angle for shear. The accuracy of the model predictions relies on the corroded cross section loss input. In the light of the comparison of test and models results a methodology setup in the literature is here extended with scenarios considering higher levels of corrosion damage.