bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing Global Long-Term EROI of Gas: A Net-Energy Perspective on the Energy Transition
Authors: Delannoy Louis , Longaretti Pierre-Yves , Murphy David. J. , Prados Emmanuel
Published: August 2021

Natural gas is expected to play an important role in the coming low-carbon energy transition. However, conventional gas resources are gradually being replaced by unconventional ones and a question remains: to what extent is net-energy production impacted by the use of lower-quality energy sources? This aspect of the energy transition was only partially explored in previous discussions. To fill this gap, this paper incorporates standard energy-return-on-investment (EROI) estimates and dynamic functions into the GlobalShift bottom-up model at a global level. We find that the energy necessary to produce gas (including direct and indirect energy and material costs) corresponds to 6.7% of the gross energy produced at present, and is growing at an exponential rate: by 2050, it will reach 23.7%. Our results highlight the necessity of viewing the energy transition through the net-energy prism and call for a greater number of EROI studies.
Optimization and Analysis of Multilayer Planar Spiral Coils for the Application of Magnetic Resonance Wireless Power Transfer to Wearable Devices
Authors: Park Young-Jin , Kim Ji-Eun , Na Kyung-Min , Yang Ki-Dong , Cho Kyung-Hwan
Published: August 2021

In this study, small multilayer planar spiral coils were analyzed and optimized to wirelessly charge an in-ear wearable bio-signal monitoring device in a wine-glass-shaped transmitter (Tx) based on magnetic resonance wireless power transfer (MR-WPT). For analysis of these coils, a volume filament model (VFM) was used, and an equivalent circuit formulation for the VFM was proposed. The proposed method was applied to design effective multilayer coils with a diameter and height of 6 and 3.8 mm, respectively, in the wearable device. For the coils, a printed circuit board having a 0.6 mm thick dielectric substrate and a 2 oz thick copper metal was used. Moreover, the coils on each layer were connected in series. The dimensions of the double-, four-, and eight-layer coils were optimized for the maximum quality factor (Q-factor) and coupling efficiency. The operating frequency was 6.78 MHz. The optimal dimensions for the maximum Q-factor varied depending on the number of coil layers, pattern width, and turn number. For verification, the designed coils were fabricated and measured. For the four-layer coil, the coupling efficiency and Q-factor using the measured resistance and mutual inductance were 58.1% and 32.19, respectively. Calculations showed that the maximum Q-factor for the four-layer coil was 40.8 and the maximum coupling efficiency was 60.1%. The calculations and measurement were in good agreement. Finally, the entire system of the in-ear wearable bio-signal monitoring device, comprising a wine-glass-shaped transmitter, the designed receiving coil, and a monitoring circuit, was fabricated. The measured dc-dc efficiency of the MR-WPT system was 16.08%.
Productivity Analysis of Fuyu Oil Shale In-Situ Pyrolysis by Injecting Hot Nitrogen
Authors: Zhao Shuai , Li Qiang , Lü Xiaoshu , Sun Youhong
Published: August 2021

In this paper, the effect of heat injection on productivity of Fuyu oil shale during in-situ pyrolysis was studied by using heat flow coupling analysis method. It is found that fluid conducts heat transmission to the oil shale stratum mainly along the fissure formed by hydraulic fracturing. With the increase of heating time, the oil shale on both sides of fissures were effectively pyrolyzed, and the porosity of the formation increases and the diffusion range of the nitrogen to the oil shale stratum is also improved. After 200 days, the oil shale around the fractures first reaches the pyrolysis temperature, and 700 days later, the average temperature of the oil shale stratum reaches 500 °C; therefore, the whole oil shale can be effectively pyrolyzed. Productivity analysis shows that the best exploitation temperature is 500 °C. When the gas injection rate is in the range of 1.0~11.0 m3/min, different degrees of heat loss will occur, and the output is also different. The pyrolysis time reaches 100~150 days, showing the peak value of daily production, which is between 0.5~3.2 m3/day. The pressure of displacement fluid affects oil shale product recovery in in-situ pyrolysis. High pressure helps to improve the displacement efficiency of oil and gas products and increase the productivity of oil shale in-situ pyrolysis. The best acting pressure is 9.5 MPa.
Investigating Air-Cathode Microbial Fuel Cells Performance under Different Serially and Parallelly Connected Configurations
Authors: Minutillo Mariagiovanna , Di Micco Simona , Di Giorgio Paolo , Erme Giovanni , Jannelli Elio
Published: August 2021

Microbial fuel cells (MFCs) have recently attracted more attention in the context of sustainable energy production. They can be considered as a future solution for the treatment of organic wastes and the production of bioelectricity. However, the low output voltage and the low produced electricity limit their applications as energy supply systems. The scaling up of MFCs both by developing bigger reactors with multiple electrodes and by connecting several cells in stacked configurations is a valid solution for improving these performances. In this paper, the scaling up of a single air-cathode microbial fuel cell with an internal volume of 28 mL, has been studied to estimate how its performance can be improved (1523 mW/m3, at 0.139 mA). Four stacked configurations and a multi-electrode unit have been designed, developed, and tested. The stacked MFCs consist of 4 reactors (28 mL × 4) that are connected in series, parallel, series/parallel, and parallel/series modes. The multi-electrode unit consists of a bigger reactor (253 mL) with 4 anodes and 4 cathodes. The performance analysis has point ed out that the multi-electrode configuration shows the lowest performances in terms of volumetric power density equal to 471 mW/m3 at 0.345 mA and volumetric energy density of 624.2 Wh/m3. The stacked parallel/series configuration assures both the highest volumetric power density, equal to 2451 mW/m3 (274.6 µW) at 0.524 mA and the highest volumetric energy density, equal to 2742.0 Wh/m3. These results allow affirming that to increase the electric power output of MFCs, the stacked configuration is the optimal strategy from designing point of view.
Economic and Carbon Costs of Electricity Balancing Services: The Need for Secure Flexible Low-Carbon Generation
Authors: Lafratta Mauro , Leach Matthew , Thorpe Rex B. , Willcocks Mark , Germain Eve , Ouki Sabeha K. , Shana Achame , Lee Jacquetta
Published: August 2021

The electricity sector aims to achieve a balanced progress in all three dimensions of the energy trilemma: affordability, decarbonisation and security of supply. Separate strategies for decarbonisation and security of supply have been pursued; each with close attention to minimising costs, thus consistent with the affordability aspect of the trilemma. However, while it is evident that the pathway for decarbonisation increases pressure on security of supply, the pressures that cost-minimising security of supply measures are putting on decarbonisation goes unaddressed. The United Kingdom (UK) is a global leader in the transition towards a decarbonised economy and aims to achieve net-zero emissions by 2050. As a major part of the UK, Great Britain (GB) has achieved greater than 50% of low-carbon electricity generation and the grid’s carbon intensity has dropped by 36% over the period 2015–2019. However, balancing services that provide security of supply uses only 8% of low-carbon generation. Their carbon intensity is double the grid’s average and this gap is widening. This is an effect of a systemic reliance on carbon-intensive fuels. Financial support for capital investment for flexible low-carbon technologies is much needed. The GB context suggests that an integrated strategy covering all three dimensions of the trilemma might achieve an improved balance between them and unlock an affordable, net-zero emissions and secure power system.
Study on Evaluation Method of Impulse Dispersion Performance of Grounding Device Using X-ray Imagining System
Authors: Han Xiaoyan , Luo Donghui , Zhang Xin , Cao Yongxing , Zhang Yu , Ban Gege
Published: August 2021

When the lightning current enters the ground through the grounding system, the impulse dispersion performance can be observed by the phenomenon of soil spark discharge, which is fundamentally determined by the nearby soil. At present, engineers use an empirical formula to convert the soil spark discharge to the impulse coefficient of impulse grounding resistance. Therefore, there is no available quantitative analysis method to evaluate soil impulse dispersion performance. To solve this problem, this paper proposes an evaluation method for the impulse discharge efficiency of soil by using X-ray images, define VI as the parameter, which is the ratio of the volume of the discharge area to the peak current. Then, the rationality and validity of the method are verified. Finally, the variation rules of impulse discharge efficiency are analyzed in different soils. Results show that the VI can reflect the change rules of impulse dispersion performance more clearly under different soil conditions, and this parameter provides a new idea for enhancing the impulse dispersion performance of soil near the grounding electrode.
Verifying the Efficiency of a Diesel Particulate Filter Using Particle Counters with Two Different Measurements in Periodic Technical Inspection of Vehicles
Authors: Jarosiński Wojciech , Wiśniowski Piotr
Published: August 2021

The article presents the possibility of verifying the efficiency of a diesel particulate filter (DPF) with the use of particle counters using two different measurement methods. The tests were carried out at a vehicle inspection station using a condensation particle counter (CPC) and a diffusion charger (DC). This article presents the results of measurements of 50 vehicles. Removal of the diesel particulate filter from a vehicle is prohibited but is a known phenomenon throughout the EU. The task of periodic technical inspections is to eliminate vehicles that are inoperative and do not meet the environmental protection requirements. However, to date, European vehicle inspection stations do not have an effective tool to counter tampering with diesel particulate filters. The performed measurements allowed us to prove the hypothesis that both methods of measurement allow the effective confirmation of the presence of DPF in a vehicle during the periodic technical inspection of the vehicle and verification of the quality of its operation. In addition, the advantages and disadvantages of both measurement methods were assessed.
Thermal Switch Based on an Adsorption Material in a Heat Pipe
Authors: Winkler Markus , Teicht Christian , Corhan Patrick , Polyzoidis Angelos , Bartholomé Kilian , Schäfer-Welsen Olaf , Pappert Sandra
Published: August 2021

For many applications, the possibility of controlling heat flow by “thermal switching” could be very beneficial. Several concepts for heat switches were already proposed and tested, however, many drawbacks of these concepts are evident. In this work, we present a novel approach for thermal switching using a water-loaded adsorbent as part of the evaporator of a heat pipe. The basic idea is that the adsorbent releases water upon exceeding a certain evaporator temperature, and thus “activates” the heat pipe by providing the working fluid for thermal transport. The first part of this work concentrates on the adsorbent characterization by analyzing the adsorption isobars and isotherms and thus understanding the behavior of the system. Furthermore, a model to predict the release of water from the adsorbent in dependence of temperature was developed. Subsequently, the adsorbent was integrated into an actual heat pipe demonstrator to verify these predictions and demonstrate the thermal switching ability. Overall results revealed a very good agreement between the predictions concerning water release and the heat pipe’s thermal behavior. The obtained thermal switching ratio depends on the heating power and temperature range that is considered. Depending on whether evaporator/condenser or the adiabatic zone are considered, average switching ratios of circa 3 and 18 were found, respectively.
Effects of Spatial Boreal Forest Harvesting Practices on Efficiency through a Benchmarking Approach in Eastern Canada
Authors: Mazo Daniela , Valeria Osvaldo
Published: August 2021

In eastern Canada, harvesting practices and spatial organization of harvested sites are modulated according to ecosystem forest management objectives. We determined how spatial organization affects efficiency by evaluating wood procurement costs. A comparative analysis of efficiency was presented using a non-parametric technique, i.e., data envelopment analysis (DEA), which allows multiple variable analyses of different factors. A database of 50 harvested sites during the period 2015–2018, located along a north-south latitudinal gradient between 46° to 50°, was constructed with variables describing spatial organization (roads and dispersion of patches) and operational aspects (wood procurement costs). The evaluated financial efficiencies show high values greater than 70%. The causes of inefficiency were dispersion of the patches, distance to the mill, and the number of kilometers of built roads. When efficiency values were arranged by latitudinal location, northern sites exhibited a lower value of overall and scale efficiency due to the high values in the wood harvested, and developed road density of the zone.
Volatile Fatty Acid Production from Organic Waste with the Emphasis on Membrane-Based Recovery
Authors: Sukphun Prawat , Sittijunda Sureewan , Reungsang Alissara
Published: August 2021

In recent years, interest in the biorefinery concept has emerged in the utilization of volatile fatty acids (VFAs) produced by acidogenic fermentation as precursors for various biotechnological processes. This has attracted substantial attention to VFA production from low-cost substrates such as organic waste and membrane based VFA recovery techniques to achieve cost-effective and environmentally friendly processes. However, there are few reviews which emphasize the acidogenic fermentation of organic waste into VFAs, and VFA recovery. Therefore, this article comprehensively summarizes VFA production, the factors affecting VFA production, and VFA recovery strategies using membrane-based techniques. Additionally, the outlook for future research on VFA production is discussed.
Considerations for Categorizing and Visualizing Numerical Information: A Case Study of Fire Occurrence Prediction Models in the Province of Ontario, Canada
Authors: Boychuk Den , McFayden Colin B. , Woolford Douglas G. , Wotton Mike , Stacey Aaron , Evens Jordan , Hanes Chelene C. , Wheatley Melanie
Published: August 2021

Wildland fire management decision-makers need to quickly understand large amounts of quantitative information under stressful conditions. Categorization and visualization “schemes” have long been used to help, but how they are done affects the speed and accuracy of interpretation. Using traditional fire management schemes can unduly restrict the design of new products. Our design process for Ontario’s fine-scale, spatially explicit, daily fire occurrence prediction (FOP) models led us to develop guidance for designing new schemes. We show selected historical fire management schemes and describe our method. It includes specifying goals and requirements, exploring design options and making trade-offs. The design options include gradient continuity, hue selection, range completeness and scale linearity. We apply our method to a case study on designing the scheme for Ontario’s FOP models. We arrived at a smooth, nonlinear scale that accommodates data spanning many orders of magnitude. The colouring draws attention according to levels of concern, reveals meaningful spatial patterns and accommodates some colour vision deficiencies. Our method seems simple now but reconciles complex considerations and is useful for mapping many other datasets. Our method improved the clarity and ease of interpretation of several information products used by fire management decision-makers.
In Vitro Antimicrobial and Antibiofilm Activity of S-(-)-Limonene and R-(+)-Limonene against Fish Bacteria
Authors: da Silva Elisia Gomes , Bandeira Junior Guerino , Cargnelutti Juliana Felipetto , Santos Roberto Christ Vianna , Gündel André , Baldisserotto Bernardo
Published: August 2021

Brazilian fish farming goes together with the emergence of numerous bacterial diseases, with Aeromonas hydrophila being the main bacterial pathogen. As a consequence, antimicrobials are excessively used. Considering that antimicrobials are relatively stable and nonbiodegradable, medicinal plants and their phytochemicals have been used as alternative treatments of bacteriosis in fish farming. Limonene is a monoterpene available in two enantiomers: R-(+)-limonene and S-(-)-limonene. This study analyzed the antibacterial activity of the phytochemicals S-(-)-limonene and R-(+)-limonene against some bacteria isolated from silver catfish (Rhamdia quelen). Furthermore, by means of spectrophotometry and atomic force microscopy, we also investigated the combination therapy of phytochemicals with antimicrobials and their activity in terms of inhibiting biofilm formation. Six clinical isolates and a standard strain were selected for antimicrobial activity testing. Biofilm formation was tested in 96-well plates and nylon cubes. The most sensitive of the strains tested was the A. hydrophila strain (MF 372510). S-(-)-limonene and R-(+)-limonene had high minimum inhibitory concentrations; however, they strongly inhibited A. hydrophila biofilm formation. R-(+)-limonene and S-(-)-limonene had an additive effect when combined with florfenicol and an antagonistic effect with oxytetracycline. In general, the phytochemicals tested showed strong antibiofilm activity against A. hydrophila, and when in combination therapy with florfenicol, they showed an additive effect against the treatment of A. hydrophila.
Factors Influencing Sulforaphane Content in Broccoli Sprouts and Subsequent Sulforaphane Extraction
Authors: Tříska Jan , Balík Josef , Houška Milan , Novotná Pavla , Magner Martin , Vrchotová Naděžda , Híc Pavel , Jílek Ladislav , Thorová Kateřina , Šnurkovič Petr , Soural Ivo
Published: August 2021

Broccoli sprouts contain 10–100 times higher levels of sulforaphane than mature plants, something that has been well known since 1997. Sulforaphane has a whole range of unique biological properties, and it is especially an inducer of phase 2 detoxication enzymes. Therefore, its use has been intensively studied in the field of health and nutrition. The formation of sulforaphane is controlled by the epithiospecifier protein, a myrosinase co-factor, which is temperature-specific. This paper studies the influence of temperature, heating time, the addition of myrosinase in the form of Raphanus sativus sprouts in constant ratio to broccoli sprouts, and other technological steps on the final sulforaphane content in broccoli sprout homogenates. These technological steps are very important for preserving sulforaphane in broccoli sprouts, but there are some limitations concerning the amount of sulforaphane. We focused, therefore, on the extraction process, using suitable β-cyclodextrin, hexane and ethanol, with the goal of increasing the amount of sulforaphane in the final extract, thus stabilizing it and reducing the required amount sulforaphane needed, e.g., as a dietary supplement.
In Utero Fetal Weight in Pigs Is Regulated by microRNAs and Their Target Genes
Authors: Ali Asghar , Murani Eduard , Hadlich Frieder , Liu Xuan , Wimmers Klaus , Ponsuksili Siriluck
Published: August 2021

Impaired skeletal muscle growth in utero can result in reduced birth weight and poor carcass quality in pigs. Recently, we showed the role of microRNAs (miRNAs) and their target genes in prenatal skeletal muscle development and pathogenesis of intrauterine growth restriction (IUGR). In this study, we performed an integrative miRNA-mRNA transcriptomic analysis in longissimus dorsi muscle (LDM) of pig fetuses at 63 days post conception (dpc) to identify miRNAs and genes correlated to fetal weight. We found 13 miRNAs in LDM significantly correlated to fetal weight, including miR-140, miR-186, miR-101, miR-15, miR-24, miR-29, miR-449, miR-27, miR-142, miR-99, miR-181, miR-199, and miR-210. The expression of these miRNAs decreased with an increase in fetal weight. We also identified 1315 genes significantly correlated to fetal weight at 63 dpc, of which 135 genes were negatively correlated as well as identified as potential targets of the above-listed 13 miRNAs. These miRNAs and their target genes enriched pathways and biological processes important for fetal growth, development, and metabolism. These results indicate that the transcriptomic profile of skeletal muscle can be used to predict fetal weight, and miRNAs correlated to fetal weight can serve as potential biomarkers of prenatal fetal health and growth.
Cloud Optimized Raster Encoding (CORE): A Web-Native Streamable Format for Large Environmental Time Series
Authors: Iosifescu Enescu Ionuț , de Espona Lucia , Haas-Artho Dominik , Kurup Buchholz Rebecca , Hanimann David , Rüetschi Marius , Karger Dirk Nikolaus , Plattner Gian-Kasper , Hägeli Martin , Ginzler Christian , Zimmermann Niklaus E. , Pellissier Loïc
Published: August 2021

The Environmental Data Portal EnviDat aims to fuse data publication repository functionalities with next-generation web-based environmental geospatial information systems (web-EGIS) and Earth Observation (EO) data cube functionalities. User requirements related to mapping and visualization represent a major challenge for current environmental data portals. The new Cloud Optimized Raster Encoding (CORE) format enables an efficient storage and management of gridded data by applying video encoding algorithms. Inspired by the cloud optimized GeoTIFF (COG) format, the design of CORE is based on the same principles that enable efficient workflows on the cloud, addressing web-EGIS visualization challenges for large environmental time series in geosciences. CORE is a web-native streamable format that can compactly contain raster imagery as a data hypercube. It enables simultaneous exchange, preservation, and fast visualization of time series raster data in environmental repositories. The CORE format specifications are open source and can be used by other platforms to manage and visualize large environmental time series.
Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR-T Therapies for the Treatment of Cancer (1997–2020)
Authors: Ivica Nikola A. , Young Colin M.
Published: August 2021

Chimeric antigen receptor and T-cell receptor (CAR-T/TCR-T) cellular immunotherapies have shown remarkable success in the treatment of some refractory B-cell malignancies, with potential to provide durable clinical response for other types of cancer. In this paper, we look at all available FDA CAR-T/TCR-T clinical trials for the treatment of cancer, and analyze them with respect to different disease tissues, targeted antigens, products, and originator locations. We found that 627 of 1007 registered are currently active and of those 273 (44%) originated in China and 280 (45%) in the US. Our analysis suggests that the rapid increase in the number of clinical trials is driven by the development of different CAR-T products that use a similar therapeutic approach. We coin the term bioparallels to describe such products. Our results suggest that one feature of the CAR-T/TCR-T industry may be a robust response to success and failure of competitor products.
The Cut-off Value of Physical Activity for Undergoing Total Knee Arthroplasty in Patients with Knee Osteoarthritis
Authors: Okamoto Takuya , Ikemoto Tatsunori , Miyagawa Hirofumi , Ishida Tomohiro , Akao Machiko , Takata Takuya , Kobayakawa Kyosuke , Yamanashi Yuki , Inoue Masayuki , Nakaso Yuichiro , Ushida Takahiro , Deie Masataka
Published: August 2021

Background: We aimed to determine a cut-off value for physical activity (PA), measured using an accelerometer, between patients with knee osteoarthritis (OA) who decided to undergo total knee arthroplasty (TKA) and those who continued conservative treatment. Methods: Forty-two participants were assigned to either a TKA group or a non-TKA group (21 per group). They were instructed to wear an accelerometer throughout the day. Average daily steps (steps/day), average daily time of light PA (LPA) (min/day), and average daily time of moderate-to-vigorous PA (MVPA) (min/day) were measured for seven days. Variables between the two groups were compared using univariate analyses, and then a stepwise logistic regression was conducted to determine which variables best correlated with undergoing TKA. The PA cut-offs were analysed using the receiver operating characteristic curve. Results: Pain severity (p = 0.002), KL grade (p = 0.001), and MVPA (p = 0.012) differed significantly between the groups. The most useful cut-off value was 5.84 (min/day) for MVPA (AUC = 0.773), although only pain severity and KL grade were found to be significant contributors to undergoing TKA. Conclusions: Our results revealed there was a significant decrease in PA levels (MVPA cut-off, 5–6 min/day) in the TKA group compared with the non-TKA group.
Trials and Tribulations in the Frontline Treatment of Older Adults with Acute Myeloid Leukemia
Authors: Zayac Adam S. , Reagan John L.
Published: August 2021

Acute myeloid leukemia (AML) is a heterogeneous aggressive hematologic malignancy derived from malignant clones that promote their own growth and survival at the expense of normal hematopoiesis resulting in life-threatening bleeding and infections. Traditional initial AML therapy has been centered on a backbone of intensive chemotherapy often composed of an anthracycline and cytarabine. This strategy has proven most effective in patients less than 60 years of age due to both patient-related tolerability factors as well as changes in AML biology centered on chemotherapy refractory mutational profiles that are seen with advancing age. Recent improvements in frontline AML therapy have been seen in patients 60 years of age and over, a population most typically referred to as “older” adult AML. Herein, we describe the characteristics of “older” adult AML, review the differences in outcomes amongst those 60–75 and those over 75 years of age, and cite challenges in delivering frontline therapies within this group based not only on therapeutic toxicity but also on the patient’s overall level of “fitness” and inherent biology. We also discuss the role of targeted therapies that inhibit specific mutations and have the potential to deliver improved efficacy with less side effects while also recognizing that some selected older AML patients still benefit from intensive induction therapy.
Evaluation of Debris Flows for Flood Plain Estimation in a Small Ungauged Tropical Watershed for Hurricane Otto
Authors: Fallas Salazar Sebastián , Rojas González Alejandra M.
Published: August 2021

The variability of climate, increase in population, and lack of territorial plans in Costa Rica have caused intense disasters with human and economic losses. In 2016, Hurricane Otto hit the country’s northern area, leaving substantial damages, including landslides, debris flows, and flooding. The present study evaluated different scenarios to estimate flooded areas for Newtonian (clean water), and non-Newtonian flows with volumetric sediment concentrations (Cv) of 0.3, 0.45, 0.55, and 0.65 using Hydro-Estimator (HE), rain gauge station, and the 100-year return period event. HEC–HMS modeled the rainfall products, and FLO-2D modeled the hydrographs and Cv combinations. The simulation results were evaluated with continuous statistics, contingency table, Nash Sutcliffe Efficiency, measure of fit (F), and mean absolute differences (E) in the floodplains. Flow depths, velocities, and hazard intensities were obtained in the floodplain. The debris flood was validated with field data and classified with a Cv of 0.45, presenting lower MAE and RMSE. Results indicated no significant differences in flood depths between hydrological scenarios with clean-water simulations with a difference of 8.38% in the peak flow. The flood plain generated with HE rainfall and clear-water condition presented similar results compared to the rain gauge input source. Additionally, hydraulic results with HE and Cv of 0.45 presented E and F values similar to the simulation of Cv of 0.3, demonstrating that the HE bias did not influence the determination of the floodplain depth and extent. A mean bias factor can be applied to a sub-daily temporal resolution to enhance HE rain rate quantifications and floodplain determination.
Nutrient Atmospheric Deposition on Utah Lake: A Comparison of Sampling and Analytical Methods
Authors: Barrus Seth Michael , Williams Gustavious Paul , Miller A. Woodruff , Borup M. Brett , Merritt LaVere B. , Richards David C. , Miller Theron G.
Published: August 2021

We describe modified sampling and analysis methods to quantify nutrient atmospheric deposition (AD) and estimate Utah Lake nutrient loading. We address criticisms of previous published collection methods, specifically collection table height, screened buckets, and assumptions of AD spatial patterns. We generally follow National Atmospheric Deposition Program (NADP) recommendations but deviate to measure lake AD, which includes deposition from both local and long-range sources. The NADP guidelines are designed to eliminate local contributions to the extent possible, while lake AD loads should include local contributions. We collected side-by-side data with tables at 1 m (previous results) and 2 m (NADP guidelines) above the ground at two separate locations. We found no statistically significant difference between data collected at the different heights. Previous published work assumed AD rates would decrease rapidly from the shore. We collected data from the lake interior and show that AD rates do not significantly decline away from the shore. This demonstrates that AD loads should be estimated by using the available data and geostatistical methods even if all data are from shoreline stations. We evaluated screening collection buckets. Standard unscreened AD samples had up to 3-fold higher nutrient concentrations than screened AD collections. It is not clear which samples best represent lake AD rates, but we recommend the use of screens and placed screens on all sample buckets for the majority of the 2020 data to exclude insects and other larger objects such as leaves. We updated AD load estimates for Utah Lake. Previous published estimates computed total AD loads of 350 and 153 tons of total phosphorous (TP) and 460 and 505 tons of dissolve inorganic nitrogen (DIN) for 2017 and 2018, respectively. Using updated collection methods, we estimated 262 and 133 tons of TP and 1052 and 482 tons of DIN for 2019 and 2020, respectively. The 2020 results used screened samplers with lower AD rates, which resulted in significantly lower totals than 2019. We present these modified methods and use data and analysis to support the updated methods and assumptions to help guide other studies of nutrient AD on lakes and reservoirs. We show that AD nutrient loads can be a significant amount of the total load and should be included in load studies.
Health-Related Quality of Life Norm Data of the Peruvian Adolescents: Results Using the EQ-5D-Y
Authors: Palacios-Cartagena Roxana Paola , Adsuar Jose Carmelo , Hernández-Mocholí Miguel Ángel , Carlos-Vivas Jorge , Barrios-Fernández Sabina , Garcia-Gordillo Miguel Angel , Mendoza-Muñoz María
Published: August 2021

(1) Introduction: There is a growing interest in health-related quality of life (HRQOL) in adolescent population. The EQ-5D-Y is a generic HRQOL instrument that allows adolescents to understand the health status of different levels of physical, mental, and social health. This study was carried out with an adolescent population in Peru. The main objective of this article is to report the normative values of the EQ-5D-Y questionnaire in Peruvian adolescents. (2) Methods: The EQ-5D-Y questionnaire was administered to Peruvian adolescent students. A total of 1229 young people participated in the survey. The EQ-5D-Y score was reflected as a function of sex and age. (3) Results: The mean utility index of the EQ-5D-Y for the total sample was 0.890; this rating was significantly better for males at (0.899) and females at (0.881). The ceiling effect was higher for adolescent males with (47.3) females (40.7). (4) Conclusions: The results of the present study provide evidence that schooled adolescents show a positive perception of HRQOL.
China’s Successful Recruitment of Healthcare Professionals to the Worst-Hit City: A Lesson Learned
Authors: Zhu Pingting , Liu Xinyi , Wu Qiwei , Loke Jennifer , Lim Deborah , Xu Huiwen
Published: August 2021

The outbreak of coronavirus disease in 2019 (COVID-19) in Wuhan has led Chinese health authorities to recruit healthcare providers from the least-affected areas to provide care to the infected patients in Wuhan. We took further steps to explain some plausible reasons for their experiences. We used interpretative phenomenological analysis (IPA) to understand the subjective experiences, as well as the reasons for these experiences among the healthcare providers who had traveled from the least-affected parts of China to render aid during Wuhan’s COVID-19 outbreak. Using purposive and snowball sampling, healthcare professionals were recruited from three major hospitals in Jiangsu province. Semi-structured interviews were conducted from 1 September to 14 November 2020 in face-to-face contexts. Ten nurses and four doctors provided their informed consent for the study. The primary superordinate theme from the responses highlighted how social identity and individual needs were challenged by each individual’s professional ethics. COVID-19 not only presents significant risks to the health of nurses and medical doctors; it further challenges their emotional and psychosocial wellbeing. Care should be taken in allocating support and help, with the careful deployment of professional values and beliefs, so that any human resource as precious as medical doctors and nurses can be protected.
Substantiation of Methods for Predicting Success in Artistic Swimming
Authors: Podrihalo Olha , Podrigalo Leonid , Jagiełło Władysław , Iermakov Sergii , Yermakova Tetiana
Published: August 2021

To develop a methodology for predicting success in artistic swimming based on a set of morphofunctional indicators and indices, 30 schoolgirls, average age (12.00 ± 0.22), were divided into two groups. Group 1: 15 athletes, training experience 4–5 years. Group 2: 15 schoolgirls without training experience. For each participant, we determined the length and weight of the body, the circumference of the chest, vital lung capacity, and the circumference of the biceps in a tense and at rest. The Erisman index, biceps index, and the ratio of proper and actual vital lung capacity was calculated. Them, we conducted the Stange and Genchi hypoxic tests, and flexibility tests for “Split”, “Crab position”, and “Forward bend”. Prediction was conducted using the Wald test with the calculation of predictive coefficients and their informativeness. A predictive table containing results of functional tests and indices of artistic swimming athletes is developed. It includes nine criteria, which informativeness varied in the range of 395.70–31.98. The content of the prediction consists of evaluating the results, determining the appropriate predictive coefficient, and summing these coefficients before reaching one of the predictive thresholds. The conducted research allowed us to substantiate and develop a method for predicting the success of female athletes with the use of morphofunctional indicators and indices.
Influence of Amino Acid Feeding on Production of Calcimycin and Analogs in Streptomyces chartreusis
Authors: Arend Kirstin I. , Bandow Julia E.
Published: August 2021

Streptomyces chartreusis NRRL 3882 produces the polyether ionophore calcimycin and a variety of analogs, which originate from the same biosynthetic gene cluster. The role of calcimycin and its analogs for the producer is unknown, but calcimycin has strong antibacterial activity. Feeding experiments were performed in chemically defined medium systematically supplemented with proteinogenic amino acids to analyze their individual effects on calcimycin synthesis. In the culture supernatants, in addition to known calcimycin analogs, eight so far unknown analogs were detected using LC-MS/MS. Under most conditions cezomycin was the compound produced in highest amounts. The highest production of calcimycin was detected upon feeding with glutamine. Supplementation of the medium with glutamic acid resulted in a decrease in calcimycin production, and supplementation of other amino acids such as tryptophan, lysine, and valine resulted in the decrease in the synthesis of calcimycin and of the known intermediates of the biosynthetic pathway. We demonstrated that the production of calcimycin and its analogs is strongly dependent on amino acid supply. Utilization of amino acids as precursors and as nitrogen sources seem to critically influence calcimycin synthesis. Even amino acids not serving as direct precursors resulted in a different product profile regarding the stoichiometry of calcimycin analogs. Only slight changes in cultivation conditions can lead to major changes in the metabolic output, which highlights the hidden potential of biosynthetic gene clusters. We emphasize the need to further study the extent of this potential to understand the ecological role of metabolite diversity originating from single biosynthetic gene clusters.
Chronic Obstructive Pulmonary Disease Increases the Risk of Mortality among Patients with Colorectal Cancer: A Nationwide Population-Based Retrospective Cohort Study
Authors: Cheng Wei-Jen , Chiang Chih-Chao , Peng Meng-Ting , Huang Yu-Tung , Huang Jhen-Ling , Chang Shang-Hung , Yang Hsuan-Tzu , Chen Wei-Chun , Kuo Jong-Jen , Hwang Tsong-Long
Published: August 2021

Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in Taiwan. Chronic obstructive pulmonary disease (COPD) is associated with CRC mortality in several population-based studies. However, this effect of COPD on CRC shows no difference in some studies and remains unclear in Taiwan’s population. Methods: We conducted a retrospective cohort study using Taiwan’s nationwide database. Patients newly diagnosed with CRC were identified from 2007 to 2012 via the Taiwan Cancer Registry dataset and linked to the National Health Insurance research database to obtain their medical records. Propensity score matching (PSM) was applied at a ratio of 1:2 in COPD and non-COPD patients with CRC. The 5-year overall survival (OS) was analyzed using the Cox regression method. Results: This study included 43,249 patients with CRC, reduced to 13,707 patients after PSM. OS was lower in the COPD group than in the non-COPD group. The adjusted hazard ratio (aHR) for COPD was 1.26 (95% confidence interval (CI), 1.19–1.33). Moreover, patients with CRC plus preexisting COPD showed a higher mortality risk in all stage CRC subgroup analysis. Conclusions: In this 5-year retrospective cohort study, patients with CRC and preexisting COPD had a higher mortality risk than those without preexisting COPD, suggesting these patients need more attention during treatment and follow-up.
The Families and Schools for Health Project: A Longitudinal Cluster Randomized Controlled Trial Targeting Children with Overweight and Obesity
Authors: Topham Glade L. , Washburn Isaac J. , Hubbs-Tait Laura , Kennedy Tay S. , Rutledge Julie M. , Page Melanie C. , Swindle Taren , Shriver Lenka H. , Harrist Amanda W.
Published: August 2021

This cluster randomized controlled trial aimed at overweight and obese children compared three treatments. Two psychoeducation interventions for parents and children were conducted: Family Lifestyle (FL) focused on food and physical activity; Family Dynamics (FD) added parenting and healthy emotion management. A third Peer Group (PG) intervention taught social acceptance to children. Crossing interventions yielded four conditions: FL, FL + PG, FL + FD, and FL + FD + PG—compared with the control. Longitudinal BMI data were collected to determine if family- and peer-based psychosocial components enhanced the Family Lifestyle approach. Participants were 1st graders with BMI%ile >75 (n = 538: 278 boys, 260 girls). Schools were randomly assigned to condition after stratifying for community size and percent American Indian. Anthropometric data were collected pre- and post-intervention in 1st grade and annually through 4th grade. Using a two-level random intercept growth model, intervention status predicted differences in growth in BMI or BMI-M% over three years. Children with obesity who received the FL + FD + PG intervention had lower BMI gains compared to controls for both raw BMI (B = −0.05) and BMI-M% (B = −2.36). Interventions to simultaneously improve parent, child, and peer-group behaviors related to physical and socioemotional health offer promise for long-term positive impact on child obesity.
Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase (ALAD) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon
Authors: Perini Jamila Alessandra , Silva Mayara Calixto , Vasconcellos Ana Claudia Santiago de , Viana Paulo Victor Sousa , Lima Marcelo Oliveira , Jesus Iracina Maura , Kempton Joseph William , Oliveira Rogério Adas Ayres , Hacon Sandra Souza , Basta Paulo Cesar
Published: August 2021

Genetic polymorphisms involved in mercury toxicokinetics and toxicodynamics may be associated with severe mercury toxicity. This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous children from the Brazilian Amazon. One-hundred-and-three indigenous children (under 15 years old) were included and genotyped (rs1800435) using a TaqMan validated assay. The mean age was 6.6 ± 4.5 years old, 60% were female, 49% presented with anemia, and the mean hair mercury concentration was 7.0 ± 4.5 (1.4–23.9) µg/g, with 49% exceeding the reference limit (≥6.0 µg/g). Only two children were heterozygous ALAD, while the others were all wild type. Minor allele frequency (ALAD G) and heterozygous genotype (ALAD CG) were 1% and 2%, respectively. The two children (12 and 14 years old) with the ALAD polymorphism had mercury levels above the average as well as had neurological symptoms related to chronic mercury exposure, such as visual field alterations, memory deficit, distal neuropathy, and toe amyotrophy. Both children also reported frequent consumption of fish in the diet, at least three times a week. In conclusion, our data confirm that an ALAD polymorphism can contribute to mercury half-life time, harmful effects, and neuropsychological disorders in indigenous children with chronic mercury exposure to gold mining activity.
Perioperative Hypothermia—A Narrative Review
Authors: Rauch Simon , Miller Clemens , Bräuer Anselm , Wallner Bernd , Bock Matthias , Paal Peter
Published: August 2021

Unintentional hypothermia (core temperature < 36 °C) is a common side effect in patients undergoing surgery. Several patient-centred and external factors, e.g., drugs, comorbidities, trauma, environmental temperature, type of anaesthesia, as well as extent and duration of surgery, influence core temperature. Perioperative hypothermia has negative effects on coagulation, blood loss and transfusion requirements, metabolization of drugs, surgical site infections, and discharge from the post-anaesthesia care unit. Therefore, active temperature management is required in the pre-, intra-, and postoperative period to diminish the risks of perioperative hypothermia. Temperature measurement should be done with accurate and continuous probes. Perioperative temperature management includes a bundle of warming tools adapted to individual needs and local circumstances. Warming blankets and mattresses as well as the administration of properly warmed infusions via dedicated devices are important for this purpose. Temperature management should follow checklists and be individualized to the patient’s requirements and the local possibilities.
Modeling the Characteristics of Unhealthy Air Pollution Events: A Copula Approach
Authors: Masseran Nurulkamal
Published: August 2021

This study proposes the concept of duration (D) and severity (S) measures, which were derived from unhealthy air pollution events. In parallel with that, the application of a copula model is proposed to evaluate unhealthy air pollution events with respect to their duration and severity characteristics. The bivariate criteria represented by duration and severity indicate their structural dependency, long-tail, and non-identically marginal distributions. A copula approach can provide a good statistical tool to deal with these issues and enable the extraction of valuable information from air pollution data. Based on the copula model, several statistical measurements are proposed for describing the characteristics of unhealthy air pollution events, including the Kendall’s τ correlation of the copula, the conditional probability of air pollution severity based on a given duration, the joint OR/AND return period, and the conditional D|S and conditional S|D return periods. A case study based on air pollution data indices was conducted in Klang, Malaysia. The results indicate that a copula approach is beneficial for deriving valuable information for planning and mitigating the risks of unhealthy air pollution events.
Physical Activity Interventions and Their Effects on Cognitive Function in People with Dementia: A Systematic Review and Meta-Analysis
Authors: Cardona Maria Isabel , Afi Adel , Lakicevic Nemanja , Thyrian Jochen René
Published: August 2021

Background: Physical activity (PA) has emerged as an alternative nonpharmacological approach to effectively address the effects of dementia. The primary aim was to identify and summarize PA interventions and their effects on cognitive function among persons with dementia (PwD). Methods: A systematic review was conducted with a meta-analysis using different electronic databases, such as PubMed, Embase, APA PsycNET, and the Web of Science. The identified and selected studies were randomized controlled trials (RCTs) that were written in English, published between 2000 and 2020, and implemented among PwD who received a PA intervention and whose cognitive function was measured at baseline and during a follow-up. Results: Twenty-two PA intervention studies met the eligibility criteria and showed a medium-size effect on the cognitive function of PwD, 0.4803 (95% CI = 0.1901–0.7704), with a high percentage of heterogeneity (I2 = 86%, p ≤ 0.0001). Moreover, this review complements other reviews by including eight studies that have not previously been considered. Overall, studies have methodological limitations. However, six studies implemented in the past five years have shown more robust methodological designs, including larger sample sizes and more comprehensive measurement tools. Conclusion: It is not yet possible to draw a conclusion on the ideal PA intervention for this population due to the high proportion of heterogeneity within the included studies. More emphasis is needed on the intensity of PA monitoring and adherence to such programs.