bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Complementary Health Provision of the Podiatric Foot Care Program for Diabetic Patients in Catalonia (Spain)
Authors: Ruiz-Toledo Jessica , Zalacain-Vicuña Antonio J. , de Planell-Mas Elena
Published: May 2021

The Catalan diabetic foot health program was established in 2009 in order to prevent complications caused by type 2 diabetes. This study aims to describe its application from 2009 to 2018. The objective was to describe diabetic foot care provision in the National Health System of Catalonia between 2009 and 2018, including the number of patients and professionals involved, the causes behind patients’ visits, and the most demanded codes for diagnosis and treatment filled by the podiatrist in each consultation during 2018–2020. This description was addressed through an analysis of the database provided by the Association of Podiatrists to evaluate the implementation of the program. The results for the diabetic foot health program in Catalonia showed a growth in demand from 2009 (1726) to 2018 (213,095) in terms of visits and from 2009 (1541) to 2018 (104,629) in terms of patients. The number of registered podiatrists from 2009 to 2018 increased from 165 to 470. The most commonly used diagnosis codes were (a) without sensory alterations in control and treatment of grade 1 lesions; (b) grade 0 without neuropathic, vascular, structural, or biomechanical alteration; (c) no sensory structural alterations in the foot; (d) keratopathies. The treatments most commonly used were (a) conservative (chiropody), (b) without ortho-podiatric treatment, and (c) plantar supports. The conclusions show that the health program is in great demand amongst the population. Similarly, the coding system has made it possible to identify the diagnosis and treatment of such demand.
Impacts of Psychopharmaceuticals on the Neurodevelopment of Aquatic Wildlife: A Call for Increased Knowledge Exchange across Disciplines to Highlight Implications for Human Health
Authors: Chan Stephanie J. , Nutting Veronica I. , Natterson Talia A. , Horowitz Barbara N.
Published: May 2021

The global use of psychopharmaceuticals such as antidepressants has been steadily increasing. However, the environmental consequences of increased use are rarely considered by medical professionals. Worldwide monitoring efforts have shown that pharmaceuticals are amongst the multitude of anthropogenic pollutants found in our waterways, where excretion via urine and feces is thought to be the primary mode of pharmaceutical contamination. Despite the lack of clarity surrounding the effects of the unintentional exposure to these chemicals, most notably in babies and in developing fetuses, the US Environmental Protection Agency does not currently regulate any psychopharmaceuticals in drinking water. As the underlying reasons for the increased incidence of mental illness—particularly in young children and adolescents—are poorly understood, the potential effects of unintentional exposure warrant more attention. Thus, although links between environmental contamination and physiological and behavioral changes in wildlife species—most notably in fish—have been used by ecologists and wildlife biologists to drive conservation policy and management practices, we hypothesize that this knowledge may be underutilized by medical professionals. In order to test this hypothesis, we created a hierarchically-organized citation network built around a highly-cited “parent” article to explore connections between aquatic toxicology and medical fields related to neurodevelopment. As suspected, we observed that studies in medical fields such as developmental neuroscience, obstetrics and gynecology, pediatrics, and psychiatry cite very few to no papers in the aquatic sciences. Our results underscore the need for increased transdisciplinary communication and information exchange between the aquatic sciences and medical fields.
Statistical Analysis of the Axillary Temperatures Measured by a Predictive Electronic Thermometer in Healthy Japanese Adults
Authors: Yoshihara Tatsuya , Zaitsu Masayoshi , Ito Kazuya , Chung Eunhee , Matsumoto Mayumi , Manabe Junko , Sakamoto Takashi , Tsukikawa Hiroshi , Nakagawa Misato , Shingu Masami , Matsuki Shunji , Irie Shin
Published: May 2021

Body temperature is important for diagnosing illnesses. However, its assessment is often a difficult task, considering the large individual differences. Although 37 °C has been the gold standard of body temperature for over a century, the temperature of modern people is reportedly decreasing year by year. However, a mean axillary temperature of 36.89 ± 0.34 °C reported in 1957 is still cited in Japan. To assess the measured axillary temperature appropriately, understanding its distribution in modern people is important. This study retrospectively analyzed 2454 axillary temperature measurement data of healthy Japanese adults in 2019 (age range, 20–79 years; 2258 males). Their mean temperature was 36.47 ± 0.28 °C (36.48 ± 0.27 °C in males and 36.35 ± 0.31 °C in females). Approximately 5% of the 20–39-year-old males had body temperature ≥37 °C, whereas 8% had a temperature ≥ 37 °C in the afternoon. However, none of the subjects aged ≥50 years reported body temperature ≥37 °C. In multivariable regression analysis, age, blood pressure, pulse rate, and measurement time of the day were associated with axillary temperature. Our data showed that the body temperature of modern Japanese adults was lower than that reported previously. When assessing body temperature, the age, blood pressure, pulse rate, and measurement time of the day should be considered.
Oncotype DX Test Receipt among Latina/Hispanic Women with Early Invasive Breast Cancer in New Jersey: A Registry-Based Study
Authors: Acuna Nicholas , Plascak Jesse J. , Tsui Jennifer , Stroup Antoinette M. , Llanos Adana A. M.
Published: May 2021

Oncotype DX® (ODX) is a valid test of breast cancer (BC) recurrence risk and chemotherapy benefit. The purpose of this study was to examine prevalence of and factors associated with receipt of ODX testing among eligible Latinas/Hispanics diagnosed with BC. Sociodemographic and tumor data of BC cases diagnosed between 2008 and 2017 among Latina/Hispanic women (n = 5777) were from the New Jersey State Cancer Registry (NJSCR). Eligibility for ODX testing were based on National Comprehensive Cancer Network guidelines. Multivariable logistic regression models of ODX receipt among eligible women were used to estimate adjusted odds ratios (AOR) and 95% confidence intervals (CI) by demographic and clinicopathologic factors. One-third of Latinas/Hispanics diagnosed with BC were eligible for ODX testing. Among the eligible, 60.9% received ODX testing. Older age (AOR 0.08, 95% CI: 0.04, 0.14), low area-level SES (AOR 0.58, 95% CI: 0.42, 0.52), and being uninsured (AOR 0.58, 95% CI: 0.39, 0.86) were associated with lower odds of ODX testing. While there was relatively high ODX testing among eligible Latina/Hispanic women with BC in New Jersey, our findings suggest that age, insurance status, and area-level SES contribute to unequal access to genetic testing in this group, which might impact BC outcomes.
Psychometric Properties and Measurement Invariance of the Maslach Burnout Inventory–General Survey in Colombia
Authors: Bravo Diana M. , Suárez-Falcón Juan C. , Bianchi Javier M. , Segura-Vargas Miguel A. , Ruiz Francisco J.
Published: May 2021

The Maslach Burnout Inventory–General Survey (MBI-GS) is a widely used scale that measures burnout in the general professions. Debate persists regarding the factor structure of the MBI-GS, and there is scarce empirical evidence about the reliability, validity, and measurement invariance of the MBI-GS in Spanish-speaking samples. Moreover, the psychometric properties of the MBI-GS have not been analyzed in Colombia. This study aimed to analyze the internal consistency, factor structure, measurement invariance, and convergent validity of the MBI-GS in a large sample of Colombian workers. The MBI-GS was administered to a total sample of 978 workers from three private companies in Bogotá (66.9% males, 32.7% females, 0.4% other). All subscales showed adequate internal consistency (alphas ranging from 0.72 to 0.86). The three-factor model demonstrated a very good fit to the data (root mean square error of approximation − RMSEA = 0.05, comparative fit index − CFI = 0.99, non-normed fit index − NNFI = 0.98, and standardized root mean square residual − SRMR = 0.06). The measurement invariance both at a metric and scalar level was supported across gender, age group, and socioeconomic status. The MBI-GS subscales showed the expected correlations with job satisfaction, work engagement, psychological distress, and psychological inflexibility. In conclusion, the Spanish version of the MBI-GS demonstrated good psychometric properties in a Colombian sample.
Effects of Ultratrail Running on Neuromuscular Function, Muscle Damage and Hydration Status. Differences According to Training Level
Authors: Pradas Francisco , Falcón David , Peñarrubia-Lozano Carlos , Toro-Román Víctor , Carrasco Luis , Castellar Carlos
Published: May 2021

The status of trail running races has exponentially grown in recent years. The present study aimed to: (a) evaluate the acute response of ultratrail racing in terms of neuromuscular function, muscle damage and hydration status; (b) analyze if responses could differ according to training levels. Twenty runners participated in the present study. The participants were divided into amateur training level (n = 10; 43.30 ± 4.52 years) or high level competitors (n = 10; 41.40 ± 6.18). Neuromuscular response (squat jump, countermovement jump and Abalakov jump), muscle damage (alanine aminotransferase, bilirubin, creatine kinase and leukocytes) and hydration status (sodium and creatinine) were evaluated before and after the Guara Somontano Ultratrail Race (108 km distance, with an accumulated slope of 5800 m). The height and power achieved by vertical jumps were lower after the race (p < 0.001). The post-race muscle damage and creatinine parameters increased in both groups (p < 0.001). The high-level group obtained lower percentages of change in squat jump and countermovement jump than the amateur-level group (p < 0.05). However, the increase in creatinine was greater for the high-level group (p < 0.05). Ultratrail racing reduces neuromuscular function and increases muscle damage. High-level runners showed less neuromuscular fatigue compared to amateur ones.
Trends in Catastrophic Occupational Incidents among Electrical Contractors, 2007–2013
Authors: Gholizadeh Pouya , Onuchukwu Ikechukwu S. , Esmaeili Behzad
Published: May 2021

This study used methodologies of descriptive and quantitative statistics to identify the contributing factors most affecting occupational accident outcomes among electrical contracting enterprises, given an accident occurred. Accident reports were collected from the Occupational Safety and Health Administration’s fatality and catastrophe database. To ensure the reliability of the data, the team manually codified more than 600 incidents through a comprehensive content analysis using injury-classification standards. Inclusive of both fatal and non-fatal injuries, the results showed that most accidents happened in nonresidential buildings, new construction, and small projects (i.e., $50,000 or less). The main source of injuries manifested in parts and materials (46%), followed by tools, instruments, and equipment (19%), and structure and surfaces (16%). The most frequent types of injuries were fractures (31%), electrocutions (27%), and electrical burns (14%); the main injured body parts were upper extremities (25%), head (23%), and body system (18%). Among non-fatal cases, falls (37%), exposure to electricity (36%), and contact with objects (19%) caused most injuries; among fatal cases, exposure to electricity was the leading cause of death (50%), followed by falls (28%) and contact with objects (19%). The analysis also investigated the impact of several accident factors on the degree of injuries and found significant effects from such factors such as project type, source of injury, cause of injury, injured part of body, nature of injury, and eventtype. In other words, the statistical probability of a fatal accident—given an accident occurrence—changes significantly based on the degree of these factors. The results of this study, as depicted in the proposed decision tree model, revealed that the most important factor for predicting the nature of injury (electrical or non-electrical) is: whether the source of injury is parts and materials; followed by whether the source of injury is tools, instruments, and equipment. In other words, in predicting (with a 94.31% accuracy) the nature of injury as electrical or non-electrical, whether the source of injury is parts and materials and whether the source of injury is tools, instruments, and equipment are very important. Seven decision rules were derived from the proposed decision tree model. Beyond these outcomes, the described methodology contributes to the accident-analysis body of knowledge by providing a framework for codifying data from accident reports to facilitate future analysis and modeling attempts to subsequently mitigate more injuries in other fields.
Greenspace, Air Pollution, Neighborhood Factors, and Preeclampsia in a Population-Based Case-Control Study in California
Authors: Weber Kari A. , Yang Wei , Lyons Evan , Stevenson David K. , Padula Amy M. , Shaw Gary M.
Published: May 2021

To investigate preeclampsia etiologies, we examined relationships between greenspace, air pollution, and neighborhood factors. Data were from hospital records and geocoded residences of 77,406 women in San Joaquin Valley, California from 2000 to 2006. Preeclampsia was divided into mild, severe, or superimposed onto pre-existing hypertension. Greenspace within 100 and 500 m residential buffers was estimated from satellite data using normalized difference vegetation index (NDVI). Air quality data were averaged over pregnancy from daily 24-h averages of nitrogen dioxide, particulate matter <10 µm (PM10) and <2.5 µm (PM2.5), and carbon monoxide. Neighborhood socioeconomic (SES) factors included living below the federal poverty level and median annual income using 2000 US Census data. Odds of preeclampsia were estimated using logistic regression. Effect modification was assessed using Wald tests. More greenspace (500 m) was inversely associated with superimposed preeclampsia (OR = 0.57). High PM2.5 and low SES were associated with mild and severe preeclampsia. We observed differences in associations between greenspace (500 m) and superimposed preeclampsia by neighborhood income and between greenspace (500 m) and severe preeclampsia by PM10, overall and among those living in higher SES neighborhoods. Less greenspace, high particulate matter, and high-poverty/low-income neighborhoods were associated with preeclampsia, and effect modification was observed between these exposures. Further research into exposure combinations and preeclampsia is warranted.
Natural and Political Determinants of Ecological Vulnerability in the Qinghai–Tibet Plateau: A Case Study of Shannan, China
Authors: Jiang Yunxiao , Li Rong , Shi Yu , Guo Luo
Published: May 2021

Changing land-use patterns in the Qinghai–Tibet Plateau (QTP) due to natural factors and human interference have led to higher ecological vulnerability and even more underlying issues related to time and space in this alpine area. Ecological vulnerability assessment provides not only a solution to surface-feature-related problems but also insight into sustainable eco-environmental planning and resource management as a response to potential climate changes if driving factors are known. In this study, the ecological vulnerability index (EVI) of Shannan City in the core area of the QTP was assessed using a selected set of ecological, social, and economic indicators and spatial principal component analysis (SPCA) to calculate their weights. The data included Landsat images and socio-economic data from 1990 to 2015, at five-year intervals. The results showed that the total EVI remains at a medium vulnerability level, with minor fluctuations over 25 years (peaks in 2000, when there was a sudden increase in slight vulnerability, which switched to extreme vulnerability), and gradually increases from east to west. In addition, spatial analysis showed a distinct positive correlation between the EVI and land-use degree, livestock husbandry output, desertification area, and grassland area. The artificial afforestation program (AAP) has a positive effect by preventing the environment from becoming more vulnerable. The results provide practical information and suggestions for planners to take measures to improve the land-use degree in urban and pastoral areas in the QTP based on spatial-temporal heterogeneity patterns of the EVI of Shannan City.
A Study of Multilingual Toxic Text Detection Approaches under Imbalanced Sample Distribution
Authors: Song Guizhe , Huang Degen , Xiao Zhifeng
Published: May 2021

Multilingual characteristics, lack of annotated data, and imbalanced sample distribution are the three main challenges for toxic comment analysis in a multilingual setting. This paper proposes a multilingual toxic text classifier which adopts a novel fusion strategy that combines different loss functions and multiple pre-training models. Specifically, the proposed learning pipeline starts with a series of pre-processing steps, including translation, word segmentation, purification, text digitization, and vectorization, to convert word tokens to a vectorized form suitable for the downstream tasks. Two models, multilingual bidirectional encoder representation from transformers (MBERT) and XLM-RoBERTa (XLM-R), are employed for pre-training through Masking Language Modeling (MLM) and Translation Language Modeling (TLM), which incorporate semantic and contextual information into the models. We train six base models and fuse them to obtain three fusion models using the F1 scores as the weights. The models are evaluated on the Jigsaw Multilingual Toxic Comment dataset. Experimental results show that the best fusion model outperforms the two state-of-the-art models, MBERT and XLM-R, in F1 score by 5.05% and 0.76%, respectively, verifying the effectiveness and robustness of the proposed fusion strategy.
Multi-Task Learning for Sentiment Analysis with Hard-Sharing and Task Recognition Mechanisms
Authors: Zhang Jian , Yan Ke , Mo Yuchang
Published: May 2021

In the era of big data, multi-task learning has become one of the crucial technologies for sentiment analysis and classification. Most of the existing multi-task learning models for sentiment analysis are developed based on the soft-sharing mechanism that has less interference between different tasks than the hard-sharing mechanism. However, there are also fewer essential features that the model can extract with the soft-sharing method, resulting in unsatisfactory classification performance. In this paper, we propose a multi-task learning framework based on a hard-sharing mechanism for sentiment analysis in various fields. The hard-sharing mechanism is achieved by a shared layer to build the interrelationship among multiple tasks. Then, we design a task recognition mechanism to reduce the interference of the hard-shared feature space and also to enhance the correlation between multiple tasks. Experiments on two real-world sentiment classification datasets show that our approach achieves the best results and improves the classification accuracy over the existing methods significantly. The task recognition training process enables a unique representation of the features of different tasks in the shared feature space, providing a new solution reducing interference in the shared feature space for sentiment analysis.
Host Range and Impact of Dichrorampha aeratana, the First Potential Biological Control Agent for Leucanthemum vulgare in North America and Australia
Authors: Stutz Sonja , De Clerck-Floate Rosemarie , Hinz Hariet L. , McClay Alec , McConnachie Andrew J. , Schaffner Urs
Published: May 2021

We evaluated the potential of the European root-feeding moth Dichrorampha aeratana as a biological control agent for the invasive weed Leucanthemum vulgare (oxeye daisy) in North America and Australia. The taxonomic proximity of the ornamental Shasta daisy (Leucanthemum × superbum) to L. vulgare and its popularity in North America made finding sufficiently host-specific biological control agents a challenge. No-choice tests conducted with 74 non-target species revealed partial or complete larval development on 11 species. In multiple-choice oviposition and larval development tests that were conducted in field cages, larvae were found on five of these, however in multiple-choice tests conducted under open-field conditions, larvae were only found on the ornamentals Shasta daisy and creeping daisy (Mauranthemum paludosum). Larval feeding by D. aeratana had no measurable impact on Shasta daisy, but larval feeding and plant competition reduced the biomass and number of flower heads of L. vulgare. We conclude that D. aeratana is a suitable biological control agent because it will not affect the ornamental value of Shasta or creeping daisies and because it is unlikely to feed on any other economically important or native species. We also expect D. aeratana to contribute to the suppression of L. vulgare populations.
A Review of the Role of the Intestinal Microbiota in Age-Related Macular Degeneration
Authors: Lin Phoebe , McClintic Scott M. , Nadeem Urooba , Skondra Dimitra
Published: May 2021

Blindness from age-related macular degeneration (AMD) is an escalating problem, yet AMD pathogenesis is incompletely understood and treatments are limited. The intestinal microbiota is highly influential in ocular and extraocular diseases with inflammatory components, such as AMD. This article reviews data supporting the role of the intestinal microbiota in AMD pathogenesis. Multiple groups have found an intestinal dysbiosis in advanced AMD. There is growing evidence that environmental factors associated with AMD progression potentially work through the intestinal microbiota. A high-fat diet in apo-E-/- mice exacerbated wet and dry AMD features, presumably through changes in the intestinal microbiome, though other independent mechanisms related to lipid metabolism are also likely at play. AREDS supplementation reversed some adverse intestinal microbial changes in AMD patients. Part of the mechanism of intestinal microbial effects on retinal disease progression is via microbiota-induced microglial activation. The microbiota are at the intersection of genetics and AMD. Higher genetic risk was associated with lower intestinal bacterial diversity in AMD. Microbiota-induced metabolite production and gene expression occur in pathways important in AMD pathogenesis. These studies suggest a crucial link between the intestinal microbiota and AMD pathogenesis, thus providing a novel potential therapeutic target. Thus, the need for large longitudinal studies in patients and germ-free or gnotobiotic animal models has never been more pressing.
Breast Cancer-Related Lymphedema: Recent Updates on Diagnosis, Severity and Available Treatments
Authors: Pappalardo Marco , Starnoni Marta , Franceschini Gianluca , Baccarani Alessio , De Santis Giorgio
Published: May 2021

Breast cancer-related lymphedema (BCRL) represents a global healthcare issue affecting the emotional and life quality of breast cancer survivors significantly. The clinical presentation is characterized by swelling of the affected upper limb, that may be accompanied by atrophic skin findings, pain and recurrent cellulitis. Cardinal principles of lymphedema management are the use of complex decongestive therapy and patient education. Recently, new microsurgery procedures have been reported with interesting results, bringing in a new opportunity to care postmastectomy lymphedema. However, many aspects of the disease are still debated in the medical community, including clinical examination, imaging techniques, patient selection and proper treatment. Here we will review these aspects and the current literature.
An Intelligent Method for Lead User Identification in Customer Collaborative Product Innovation
Authors: Su Jiafu , Chen Xu , Zhang Fengting , Zhang Na , Li Fei
Published: May 2021

For customer collaborative product innovation (CCPI), lead users are powerful enablers of product innovation. Identifying lead users is vital to successfully carrying out CCPI. In this paper, in order to overcome the shortcomings of traditional evaluation methods, a novel intelligent method is proposed to identify lead users efficiently based on the cost-sensitive learning and support vector machine theory. To this end, the characteristics of lead users in CCPI are first analyzed and concluded in-depth. On its basis, considering the sample misidentification cost and identification accuracy rate, an improved cost-sensitive learning support vector machine (ICS-SVM) method for lead user identification in CCPI is further proposed. A real case is provided to illustrate the effectiveness and advantages of the ICS-SVM method on lead user identification in CCPI. The case results show that the ICS-SVM method can effectively identify lead users in CCPI. This work contributes to user innovation literature by proposing a new way of identifying highly valuable lead users and offers a decision support for the efficient user management in CCPI.
China: A New Trajectory Prioritizing Rural Rather Than Urban Development?
Authors: Xu Hongzhang , Pittock Jamie , Daniell Katherine A.
Published: May 2021

The adverse effects of rapid urbanization are of global concern. Careful planning for and accommodation of accelerating urbanization and citizenization (i.e., migrants gaining official urban residency) may be the best approach to limit some of the worst impacts. However, we find that another trajectory may be possible: one linked to the rural development plan adopted in the latest Chinese national development strategy. This plan aims to build rural areas as attractive areas for settlement by 2050 rather than to further urbanize with more people in cities. We assess the political motivations and challenges behind this choice to develop rural areas based on a literature review and empirical case analysis. After assessing the rural and urban policy subsystem, we find five socio-political drivers behind China’s rural development strategy, namely ensuring food security, promoting culture and heritage, addressing overcapacity, emphasizing environmental protection and eradicating poverty. To develop rural areas, China needs to effectively resolve three dilemmas: (1) implementing decentralized policies under central supervision; (2) deploying limited resources efficiently to achieve targets; and (3) addressing competing narratives in current policies. Involving more rural community voices, adopting multiple forms of local governance, and identifying and mitigating negative project impacts can be the starting points to manage these dilemmas.
Genesis of the Yingzuihongshan Tungsten Deposit, Western Inner Mongolia Autonomous Region, North China: Constraints from In Situ Trace Elements Analyses of Scheelite
Authors: Wang Guoqiang , Li Xiangmin , Zhang Dongliang , Yu Jiyuan , Liu Yujie
Published: May 2021

In situ analyses of trace elements and rare-earth elements (REEs) were performed by use of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) on scheelite samples from the Yingzuihongshan tungsten deposit in western Inner Mongolia Autonomous Region, China. The contents of trace elements Nb, Ta and Mo of scheelite indicate that the ore-forming fluid is magmatic hydrotherm and is exsolved from highly fractionated granitic melt. The scheelite has high REE contents and ∑REE values, and a very inhomogeneous distribution of REEs exists in different scheelite grains or even in one scheelite grain. The cathodoluminescence (CL) images of scheelite grains display well-developed zoning or fine oscillatory zoning. Development of zoning is closely related to the variable contents of REEs, and the darkness of shade of CL images are mainly determined by ∑REE values, but they have no correlation with the distribution patterns of REEs. The chondrite-normalized REE distribution patterns of scheelite are classified as the middle REEs (MREEs)-enriched type, except for a strong negative Eu-anomaly, which could be a REE-flat type and or a MREEs-depleted type. Trace element composition of scheelites from the Yinzuihongshan tungsten deposit reflect that the ore-forming materials mainly came from the crust and the ore-forming fluids are dominantly derived from the granitic magma in an oxidizing environment, in which very dynamic conditions of the hydrothermal system prevailed during precipitation of scheelite. On the basis of the above understanding and field geological featured, we considered that the Yingzuihongshan tungsten deposit is the quartz-vein-hosted tungsten type that is genetically associated with monzonitic granite.
ExoProK: A Practical Method for the Isolation of Small Extracellular Vesicles from Pleural Effusions
Authors: Antonopoulos Dionysios , Tsilioni Irene , Tsiara Sophia , Moustaka Eirini , Ladias Spyridon , Perlepe Garyfallia , Theoharides Theoharis C. , Gourgoulianis Konstantinos I. , Balatsos Nikolaos A. A.
Published: May 2021

Extracellular vesicles (EVs) are cell-secreted, lipid membrane-enclosed nanoparticles without functional nucleus. EV is a general term that includes various subtypes of particles named microvesicles, microparticles, ectosomes or exosomes. EVs transfer RNA, DNA and protein cargo between proximal and distant cells and tissues, thus constituting an organism-wide signal transduction network. Pathological tissues secrete EVs that differ in their cargo composition compared to their healthy counterparts. The detection of biomarkers in EVs from biological fluids may aid the diagnosis of disease and/or monitor its progression in a minimally invasive manner. Among biological fluids, pleural effusions (PEs) are integrated to clinical practice, as they accompany a wide variety of lung disorders. Due to the proximity with the pleura and the lungs, PEs are expected to be especially enriched in EVs that originate from diseased tissues. However, PEs are among the least studied biofluids regarding EV-specialized isolation methods and related biomarkers. Herein, we describe a practical EV isolation method from PEs for the screening of EV RNA biomarkers in clinical routine. It is based on a Proteinase K treatment step to digest contaminants prior to standard polyethylene-glycol precipitation. The efficiency of the method was confirmed by transmission electron microscopy, nanoparticle tracking analysis and Western blot. The reliability and sensitivity of the method towards the detection of EV-enriched RNA biomarkers from multiple PEs was also demonstrated.
On the Thermal Models for Resistive Random Access Memory Circuit Simulation
Authors: Roldán Juan B. , González-Cordero Gerardo , Picos Rodrigo , Miranda Enrique , Palumbo Félix , Jiménez-Molinos Francisco , Moreno Enrique , Maldonado David , Baldomá Santiago B. , Moner Al Chawa Mohamad , de Benito Carol , Stavrinides Stavros G. , Suñé Jordi , Chua Leon O.
Published: May 2021

Resistive Random Access Memories (RRAMs) are based on resistive switching (RS) operation and exhibit a set of technological features that make them ideal candidates for applications related to non-volatile memories, neuromorphic computing and hardware cryptography. For the full industrial development of these devices different simulation tools and compact models are needed in order to allow computer-aided design, both at the device and circuit levels. Most of the different RRAM models presented so far in the literature deal with temperature effects since the physical mechanisms behind RS are thermally activated; therefore, an exhaustive description of these effects is essential. As far as we know, no revision papers on thermal models have been published yet; and that is why we deal with this issue here. Using the heat equation as the starting point, we describe the details of its numerical solution for a conventional RRAM structure and, later on, present models of different complexity to integrate thermal effects in complete compact models that account for the kinetics of the chemical reactions behind resistive switching and the current calculation. In particular, we have accounted for different conductive filament geometries, operation regimes, filament lateral heat losses, the use of several temperatures to characterize each conductive filament, among other issues. A 3D numerical solution of the heat equation within a complete RRAM simulator was also taken into account. A general memristor model is also formulated accounting for temperature as one of the state variables to describe electron device operation. In addition, to widen the view from different perspectives, we deal with a thermal model contextualized within the quantum point contact formalism. In this manner, the temperature can be accounted for the description of quantum effects in the RRAM charge transport mechanisms. Finally, the thermometry of conducting filaments and the corresponding models considering different dielectric materials are tackled in depth.
MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids
Authors: Villemin Didier , Moreau Bernard , Bar Nathalie
Published: May 2021

Novel 2-amino bis(2-phosphonoacetic) acids were prepared by microwave irradiation of a mixture of amine, glyoxylic acid and phosphorous acid. The reaction takes place with various amines including primary and secondary amines and polyamines, but this reaction is more sensitive to steric hindrance of amine than the similar Kabachnik–Fields reaction. Amino acids can be also transformed into the expected bis(2-phosphonoacetic) acids, with the exception of tryptophan, which gives a β-carboline product.
Molecular Epidemiological Survey of Canine Parvovirus Circulating in China from 2014 to 2019
Authors: Chen Bixia , Zhang Xiaohui , Zhu Jie , Liao Lijing , Bao Endong
Published: May 2021

The global distribution of canine parvovirus (CPV-2) derived from a closely related carnivore parvovirus poses a considerable threat to the dog population. The virus is continuously undergoing genetic evolution, giving rise to several variants. To investigate the prevalence of Chinese CPV-2 strains in recent years, a total of 30 CPV-2 strains were collected from 2018 to 2021 and the VP2 gene was sequenced and analyzed. Two variants, new CPV-2a (297Ala, 426Asn) and CPV-2c (426Glu), were identified. In contrast to previous reports, the CPV-2c variant has gained an epidemiological advantage over the new CPV-2a variant in China. To compensate for the relatively small sample size, 683 Chinese CPV-2 strains identified between 2014 and 2019 were retrieved from the GenBank database and previous publications, and analyses of these strains further supported our findings, which should be considered since the CPV-2c variant has been frequently associated with immune failure in adult dogs. VP2 protein sequence analysis revealed several amino acid substitutions, including Ala5Gly, Pro13Ser, Phe267Tyr, Tyr324Ile, Gln370Arg, Thr440Ala, and Lys570Arg. Phylogenetic analysis of full-length VP2 gene indicated a close relationship between Chinese strains and other Asian strains, suggesting mutual transmission between Asian countries. Furthermore, intercontinental transmission is a cause for concern. Surprisingly, two feline panleukopenia virus (FPV) strains with the Ile101Thr mutation in the VP2 protein were identified in canine fecal samples; FPV has been considered incapable of infecting dogs. This study clarified the epidemic characteristics of Chinese CPV-2 strains detected between 2014 and 2019, offering a reference for epidemic control. In addition, the detection of FPV in canine samples may provide information for future studies on the evolution of carnivore parvoviruses.
Competition (‘Steal’ Phenomenon) between [68Ga]Ga-PSMA-11 Uptake in Prostate Tumor Tissue Versus Healthy Tissue
Authors: van der Sar Esmée C. A. , de Keizer Bart , Lam Marnix G. E. H. , Braat Arthur J. A. T.
Published: May 2021

We aimed to clarify whether a steal ‘phenomenon’ exists by investigating if uptake of ‘prostate specific membrane antigen’ (PSMA) in prostate tumor tissue correlates with the uptake in healthy tissue. Patients with prostate cancer referred for a [68Ga]Ga-PSMA-11 PET/CT were identified retrospectively. Semi-automated quantitative image analysis was performed; fractional healthy tissue [68Ga]Ga-PSMA-11 uptake volume (HT-PSMA (SUV*cm3)) in the lacrimal, submandibular, and parotid glands, and kidneys, and the fractional total lesion [68Ga]Ga-PSMA-11 uptake volume (TL-PSMA (SUV*cm3)) of prostate cancer were used. Ninety-two patients, age 78 ± 8 years, were analyzed. Median TL-PSMA was 703.37 SUV*cm3 (IQR 119.56–2778.20), median HT-PSMA of the lacrimal, submandibular, and parotid glands, and kidneys was: 13.69 (IQR 7.29–19.06), 194.75 (IQR 133.67–276.53), 552.54 (IQR 379.98–737.16), and 8092.75 SUV*cm3 (IQR 5793.02–11,385.86), respectively. A significant (p-value ≤ 0.001) but weak–moderate correlation was found between the TL-PSMA and HT-PSMA of the parotid- and submandibular glands, and kidneys (correlation coefficient of −0.447, −0.345, and −0.394, respectively). No correlation was found between TL-PSMA and HT-PSMA of the lacrimal glands. The existence of a ‘steal’ phenomenon cannot be confirmed in this study. Healthy tissue uptake of [68Ga]Ga-PSMA-11 is only partially influenced by TL-PSMA. Thus, modification of therapeutic PSMA activity should not be adjusted based on TL-PSMA alone.
A Review of the Applications and Biodegradation of Polyhydroxyalkanoates and Poly(lactic acid) and Its Composites
Authors: Boey Jet Yin , Mohamad Lydia , Khok Yong Sen , Tay Guan Seng , Baidurah Siti
Published: May 2021

Overconsumption of plastic goods and improper handling of petroleum-derived plastic waste have brought a plethora of negative impacts to the environment, ecosystem and human health due to its recalcitrance to degradation. These drawbacks become the main driving force behind finding biopolymers with the degradable properties. With the advancement in biopolymer research, polyhydroxyalkanoate (PHA) and poly(lacyic acid) (PLA) and its composites have been alluded to as a potential alternative to replace the petrochemical counterpart. This review highlights the current synthesis process and application of PHAs and PLA and its composites for food packaging materials and coatings. These biopolymers can be further ameliorated to enhance their applicability and are discussed by including the current commercially available packaging products. Factors influencing biodegradation are outlined in the latter part of this review. The main aim of this review article is to organize the scattered available information on various aspects of PHAs and PLA, and its composites for packaging application purposes. It is evident from a literature survey of about 140 recently published papers from the past 15 years that PLA and PHA show excellent physical properties as potential food packaging materials.
Pleistocene Mammals from Pampean Region (Argentina). Biostratigraphic, Biogeographic, and Environmental Implications
Authors: Prado José Luis , Alberdi María Teresa , Bellinzoni Jonathan
Published: May 2021

The Pampean Region contains sedimentary sequences with abundant mammal fossil records, which constitute the chronological outline of the Plio–Pleistocene of South America. These classic localities have been used for more than a century to correlate with other South American regions. Throughout this time, a series of misinterpretations have appeared. To understand the stratigraphic significance of these localities and the geochronological situation of each unit referring to the Pleistocene, a critical historical study of the antecedents was carried out, evaluating the state of each unit. The biostratigraphic studies of the Pampean Region’s mammalian faunas improved the understanding of biogeographic changes taking into account the environmental fluctuations of the Pleistocene.
Development Prospects of Tourist Passenger Shipping in the Polish Part of the Vistula Lagoon
Authors: Puzdrakiewicz Krystian , Połom Marcin
Published: May 2021

The Vistula Lagoon is a cross-border area with high natural values and a developing market of tourist services. Passenger shipping is an important part of local tourism, but ship owners are insufficiently involved in planning processes and their views on creating shipping development are underrepresented. The article aims to compare the vision of the development of passenger shipping in the Polish part of the Vistula Lagoon between local governments creating the spatial policy and ship owners offering transport services. We have made an attempt to verify the development prospects. The collation of these visions was based primarily on the qualitative analysis of the content of planning and strategic documents (desk research method) and a survey conducted among all six ship owners. Thanks to the comparative analysis, it was possible to show similarities and differences and to indicate recommendations. The paper presents review of the available literature on the subject, thanks to which the research area was identified as unique in Europe. On the one hand, it is a valuable natural area, which is an important tourist destination, on the other hand, there are organizational and infrastructural limitations in meeting the needs of tourists. Then, field research was conducted, unpublished materials were collected, and surveys were conducted with the operators of passenger ships operating in the Vistula Lagoon. The performed analyses allowed for the formulation of conclusions and recommendations. Similarities in the directions of promoting tourism in the region, improving the quality of infrastructure, eliminating obstacles in international traffic and discrepancies in the co-financing of ship owners’ activities by local governments, shaping the future transport offer or the construction of the Vistula Spit canal are identified. Economic calculation, particularly vital for the private sector (ship owners), is an important criterion for verifying the assumed goals.
Welcome to the Regular World! Exploring How Female Doctorate Holders in Education Transition from Irregular to Regular Work in South Korea
Authors: Kim Hyosun , Lee Sooyong
Published: May 2021

The purpose of this study was to explore the adaptation process of female Ph.D. holders working in universities who shifted from being irregular employees to regular employees. The study adopted a qualitative approach using in-depth interviews to investigate participants’ experiences and discover any inconsistencies, as well as how they are alleviated. The basic findings of the study indicate that the adaptation process is more feasible when the gap between the personal aspect of job adaptation and the organizational environment and satisfaction with it decreases. The participants in the study joined the labour union to convert to regular jobs. However, after transitioning to full-time positions, the participants did not realize the structural aspect of the contracts they had signed. Although they expected to make their unfair situation more fair through the transition of their job positions, they still faced structural discrimination. As the participants were women with doctoral degrees, their professionalism was considered a cardinal value, and their job satisfaction varied according to the degree of matching between their work and their expertise. Moreover, during the evaluation period, they began to establish themselves as legitimate members of their teams through the employee evaluation procedure of full-time employees, which is conducted mutually rather than unilaterally. Through its in-depth interviews with transitioning university staff, this study makes a significant contribution to our understanding of how female faculty adjust to changes in their life and position in the organization following a change in their status. These findings prove that higher education institutions need focus on career development for female students as well as their faculty and staff members. Such a focus also requires more active actions by university and college members.
Examining the Factors That Affect the Preparation of Life after Retirement and Quality of Life of South Korean Adults across Different Age Groups
Authors: Kim Mi-Lyang , Lee Young-Han , Hong Seo-Youn
Published: May 2021

The aim of the current study is twofold. First, a preliminary analysis was conducted to discover the important factors in terms of preparing for life after retirement across different South Korean age groups (i.e., the 30s, 40s, and 50s). In this process, the level of importance and the statistical significance of the group difference were confirmed based on the ANOVA results. Second, a stepwise regression technique was utilized, as the main analysis, to explore the association between the preparation for life after retirement factors and perceived quality of life. One-way ANOVA analysis results indicated that there were significant differences between age groups in terms of leisure activities, psychological health, physical health, and emotional health factors (p < 0.001). No difference in factors pertaining to family relationships, finances, and social relationships was observed. Furthermore, the stepwise regression analysis results entail that financial stability and psychological health proved to be the most dominant factors associated with quality of life regardless of age. While the family relationship was an important factor for the 40s group, the 50s group perceived emotional health as an important factor that relates to their quality of life. In essence, it is important to provide educational programs and materials that are readily accessible to individuals preparing for retirement to promote successful preparation toward retirement and improving quality of life.
The Drivers of Technological Eco-Innovation—Dynamic Capabilities and Leadership
Authors: Pichlak Magdalena
Published: May 2021

In the paper, a theoretical framework that combines the multidimensional conceptualization of dynamic capabilities (sensing, seizing, and reconfiguring) with two leadership styles (transactional and transformational) and two types of eco-innovation (incremental and radical) was developed and empirically tested. The purpose of this study is to answer the key question: how different leadership styles influence the potential of dynamic capabilities to generate ecological changes. The research examining the theoretical framework was quantitative and was based on a deliberately selection of the sample, which included 54 of the most evo-innovative Polish companies. The results indicate that transformational leadership moderates the positive relationship between seizing capability and both incremental and radical technological eco-innovation, whereas transactional leadership moderates the positive relationship between reconfiguring capability and both types of analyzed changes. This paper contributes to the development of the literature by integrating three theoretical concepts, showing the importance of a given leadership style as a factor enhancing the potential of dynamic capabilities for the development of technological eco-innovation. Moreover, the study may be a contribution to a broader discussion on the specifics of eco-innovative activity and its behavioral conditions.