bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of SARS-CoV-2 transmission in congregate living settings: a multicenter prospective study
Authors: Leis Jerome A. , Chan Christina K. , Tan Charlie , Callahan James , Serapion Victoria , Pascual Brigitte , Lee Wayne , O’Brien Jaclyn , Thomas Neethu R. , Candon Heather , Crittenden Matthew , Kiss Alex , Chan Adrienne K , Ofner Marianna , Powis Jeff E.
Published: April 2024

Background:

Older adults residing in congregate living settings (CLS) such as nursing homes and independent living facilities remain at increased risk of morbidity and mortality from coronavirus disease 2019. We performed a prospective multicenter study of consecutive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) exposures to identify predictors of transmission in this setting.

Methods:

Consecutive resident SARS-CoV-2 exposures across 17 CLS were prospectively characterized from 1 September 2022 to 1 March 2023, including factors related to environment, source, and exposed resident. Room size, humidity, and ventilation were measured in locations where exposures occurred. Predictors were incorporated in a generalized estimating equation model adjusting for the correlation within CLS.

Results:

Among 670 consecutive exposures to SARS-CoV-2 across 17 CLS, transmission occurred among 328 (49.0%). Increased risk was associated with nursing homes (odds ratio (OR) = 90.8; 95% CI, 7.8–1047.4), Jack and Jill rooms (OR = 2.2; 95% CI, 1.3–3.6), from source who was pre-symptomatic (OR = 11.2; 95% CI, 4.1–30.9), symptomatic (OR = 6.5; 95% CI, 1.4–29.9), or rapid antigen test positive (OR = 35.6; 95% CI, 5.6–225.6), and in the presence of secondary exposure (OR = 6.3; 95% CI, 1.6–24.0). Exposure in dining room was associated with reduced risk (OR = 0.02; 95% CI, 0.005–0.08) as was medium room size (OR = 0.3; 95% CI, 0.2–0.6). Recent vaccination of exposed resident (OR = 0.5; 95% CI, 0.3–1.0) and increased ventilation of room (OR = 0.9; 95% CI, 0.8–1.0) were marginally associated with reduced risk.

Conclusion:

Prospective assessment of SARS-CoV-2 exposures in CLS suggests that source characteristics and location of exposure are most predictive of resident transmission. These findings can inform risk assessment and further opportunities to prevent transmission in CLS.
The Dutch moral foundations stimulus database: An adaptation and validation of moral vignettes and sociomoral images in a Dutch sample
Authors: Hopp Frederic R. , Jargow Benjamin , Kouwen Esmee , Bakker Bert N.
Published: April 2024

Moral judgments are shaped by socialization and cultural heritage. Understanding how moral considerations vary across the globe requires the systematic development of moral stimuli for use in different cultures and languages. Focusing on Dutch populations, we adapted and validated two recent instruments for examining moral judgments: (1) the Moral Foundations Vignettes (MFVs) and (2) the Socio-Moral Image Database (SMID). We translated all 120 MFVs from English into Dutch and selected 120 images from SMID that primarily display moral, immoral, or neutral content. A total of 586 crowd-workers from the Netherlands provided over 38,460 individual judgments for both stimuli sets on moral and affective dimensions. For both instruments, we find that moral judgments and relationships between the moral foundations and political orientation are similar to those reported in the US, Australia, and Brazil. We provide the validated MFV and SMID images, along with associated rating data, to enable a broader study of morality.
“Humanitarian Corridors”: A Legal Scheme to Deter Venezuelans from Entering Ecuador?
Authors: Fuentes Juan-Andrés
Published: April 2024

This article analyzes the so-called “humanitarian corridors” put in place by the Ecuadorian government as part of a domestic policy to move Venezuelan migrants out of Ecuador. Within this context, the author examines the concept of the humanitarian corridor from the perspective of international law, and demonstrates that Ecuador's corridors did not serve the purpose for which they were allegedly created.
Introduction: Gender and work in twentieth-century Italy: new approaches
Authors: Bracke Maud Anne , Favretto Ilaria , Pizzolato Nicola
Published: April 2024

This introduction to the special issue ‘Gender and Work in Twentieth-Century Italy’ draws on key strands of historical scholarship on gender and work, including women workers’ experiences, labour market discrimination, domestic work, the impact of gender norms, and ideas of masculinity and femininity on work identities. It traces the development of feminist influence within this scholarship, from making women workers’ experiences visible to challenging essentialist notions of gender identities. Drawing on post-structuralist and intersectional perspectives, particularly influenced by Joan Wallach Scott and Judith Butler, the scholarship on which this special issue is based understands gender as a system of power signified through language and social constructions, and builds on the critique of the dichotomies and essentialisations of traditional labour history, proposing a systemic and structural approach to understanding gendered experiences of work. By exploring the intersections of gender, work and power, this collection offers insights into wider European developments and challenges established historical concepts and narratives. It highlights the importance of understanding gender dynamics in shaping labour relations and social structures, ultimately contributing to a more nuanced understanding of labour and power dynamics in twentieth-century Italy and beyond.
Legal Loci and Places in the Heart: Community and Identity in Sociolegal Studies
Authors: Mertz Elizabeth
Published: April 2024

Community has been a central concept of political and legal philosophy since its beginning. It has often served as a frame of reference even when not explored as such. From the well-known opening of Aristotle's Politics to the French constitution of 1958, community has served to designate the human group with which politics and law are concerned and to which all the characteristic phenomena of political life, power, authority, law, and the rest must be referred.

—Friedrich 1959:3

The community myth is that there is now, or ever has been, a “community” in the sense of groups of like-minded individuals, living in urban areas, who share a common heritage, have similar values and norms, and share a common perception of social order… . [T]he idea of community contains many implications of the environment encompassed by the myth. Geographically and ethnically identifiable groups become “neighborhoods,” or moral entities characterized by a sense of belonging, a sense of common goals, involvement in community affairs, and a sense of wholeness.

—Crank 1994:336–37

There exists out there, somewhere, “the black community.” It once was a place where people both lived and worked. Now it is more of an idea, or an ideal, than a reality. It is like the mythical maroon colony of the Isle des Chevaliers (for those of you who have read Toni Morrison's Tar Baby), or like Brigadoon (for those of you who are culturally deprived). “The black community” of which I write is partly the manifestation of a nostalgic longing for a time when blacks were clearly distinguishable from whites and concern about the welfare of the poor was more natural than our hairdos.

—Austin 1992:1769
First record of goneplacid crab, Carcinoplax haswelli (Decapoda: Brachyura: Goneplacidae) from the Indian Ocean
Authors: Sureandiran B. , Dave T. H. , Suyani N. K. , Karuppasamy K.
Published: April 2024

A single male specimen of Goneplacid crab, Carcinoplax haswelli (Miers, 1884) is recorded for the first time from the Indian Ocean. The crab specimen was collected from the trawl bycatch landing of the commercial demersal trawler operated between 30 and 150 m depth along the Gujarat coastal region, Northwest coast of India. This C. haswelli is previously recorded from northern Australia and Taiwan to South China Sea. Until now, C. haswelli is not observed or recorded from the Indian Ocean. In the present study, detailed information regarding the taxonomic identification and previous distribution of the goneplacid crab, C. haswelli is described.
Revisiting the date of Hiḍimbā Devī temple, Manali, Kulu (Himachal Pradesh): a study of epigraphic evidence
Authors: Thakur Laxman S.
Published: April 2024

A seven-line Ṭākarī inscription on the doorjamb of the Hiḍimbā Devī temple at Manali has as yet remained undeciphered. However, the last line of the inscription was misread by J.Ph. Vogel in 1903–04, and Hirananda (1907–08) simply followed the date earlier suggested by Vogel. Neither has this historic document been translated in extenso by Vogel or Hirananda, or any other scholar. This article offers a complete translation of the inscription, its historical significance, and re-establishes the date of the temple from ad 1553 to ad 1551. This was during the reign of Bahādur Singh, the ruler of Kulu, who completed the present structure of the temple, and performed a yajña at the temple of the goddess Hiḍimbā during its consecration.
Effects of speech production training on memory across short and long delays in 5- and 6-year-olds: A pre-registered study
Authors: López Assef Belén , McDonald Margarethe , Bernard Amélie , Zamuner Tania S.
Published: April 2024

Studies on the role of speech production on learning have found a memory benefit from production labeled the “Production Effect.” While research with adults has generally shown a robust memory advantage for produced words, children show more mixed results, and the advantage is affected by age, cognitive, and linguistic factors. With adults, the Production Effect is not restricted to the immediate context but is also found after a delay. So far, no studies have investigated the effect of delayed recall on the Production Effect with children. Children aged 5 and 6 years old (n = 60) participated in two sessions. Children were trained on familiar words and images, which were heard (Listen) or produced aloud (Say). Children then performed a free recall task. One week later, children repeated the recall task and an additional recognition task. At immediate testing, there was a recency effect on words recalled from the different training conditions and a recall advantage for words produced over words heard; however, this no longer held after a 1-week delay in either the recall or recognition task. Exploratory analysis showed that vocabulary did not predict the Production Effect. Findings indicate that unlike adults, the Production Effect is not as robust in children after a delay.
When it rains, it pours: Mexico's bank nationalisation and the debt crisis of 1982
Authors: Flores Zendejas Juan
Published: April 2024

How are expropriations related to governments' debt defaults? The literature has shown that expropriation episodes and debt defaults have rarely coincided, suggesting that each event resulted from a different set of factors. The aim of this article is twofold. First, I analyse default–expropriation relationships in the years previous to the debt crisis of 1982. I show that while default and expropriation episodes did not always coincide, countries that expropriated at least once during the period were also those that defaulted more often. I observe that countries that expropriated had worse macroeconomic indicators than countries that did not. Second, I focus on the case of Mexico, when its announcement of a debt moratorium in August 1982 was followed, less than one month later, by the nationalisation of its banking system. Both events were outcomes of an acute economic crisis. The nationalisation announcement aggravated the crisis because an agreement with the International Monetary Fund (IMF) seemed increasingly uncertain. I provide evidence from the largely overlooked bond market (on which the government never defaulted) that shows that investors reacted negatively to the bank nationalisation. Finally, I present original, published and unpublished primary sources to demonstrate that commercial banks, as well as international organisations, expressed misgivings about the banks' nationalisation. This fact may have hindered the country's economic recovery through the deterioration of public confidence and a decline in foreign investment.
The interpretation of verbal moods in Spanish: A close replication of Kanwit and Geeslin (2014)
Authors: Gudmestad Aarnes , Edmonds Amanda , Henderson Carlos , Lindqvist Christina
Published: April 2024

This study is a close replication of Kanwit and Geeslin (2014), a variationist investigation of the interpretation of verbal moods in adverbial clauses in Spanish. Whereas the first language (L1) of the second-language participants in the initial study was English, we explore whether Kanwit and Geeslin’s results extend to other L1 populations—Swedish and French learners of Spanish. Participants in the replication study completed the same interpretation task and grammar test as those in the initial study. Results showed, for example, that multiple factors influenced their variable interpretation of verbal moods, there was evidence of change between course levels, and there were certain differences in interpretation between the French and Swedish groups. This study contributes to knowledge about the interpretation of a variable structure by enhancing the confirmatory power of some of the initial study’s findings, while also suggesting that the learners’ L1 leads to diverging findings.
The ambiguity of colonial international law: Three approaches to the Namibian Genocide
Authors: Goldmann Matthias
Published: April 2024

A visible sign of changing relations between the Global South and Global North are reparation claims for colonial injustice. An interesting case is the 1904–1907 Namibian Genocide. Germany has recently concluded a draft agreement with Namibia on reconciliation and compensation. Nevertheless, Germany maintains that it is not under any legal obligation to pay reparations. This article challenges that position, arguing that colonial international law was far too ambiguous to support this conclusion. For this purpose, the article contrasts this ‘conventional view’ of colonial international law with post-colonial and pluralistic approaches. Post-colonial approaches reveal colonial-era law as a deeply ambiguous, contradictory practice that mirrors the identity crisis of the colonizers. Pluralistic approaches juxtapose colonial international law with autochtonous views of inter-polity law, i.e., the normative framework governing colonial encounters. To reconstruct autochtonous views, the article draws on letters by Hendrik Witbooi and Maharero, traditional leaders from Namibia, and examines the contours of their inter-polity law relating to territorial sovereignty and warfare. These contending perspectives undermine the cogency with which the conventional view rejects reparation claims. While ambiguity as such does not give rise to compensation claims, other options come to mind, such as a duty to negotiate, shifts in the burden of proof – or a profound recalibration of international law towards greater solidarity.
Childhood maltreatment and resting-state network connectivity: The risk-buffering role of positive parenting
Authors: Cao Xinyu , Wang Zhengxinyue , Chen Yuanyuan ,   Consortium the NSPN, Zhu Jianjun
Published: April 2024

Unraveling the neurobiological foundations of childhood maltreatment is important due to the persistent associations with adverse mental health outcomes. However, the mechanisms through which abuse and neglect disturb resting-state network connectivity remain elusive. Moreover, it remains unclear if positive parenting can mitigate the negative impact of childhood maltreatment on network connectivity. We analyzed a cohort of 194 adolescents and young adults (aged 14–25, 47.42% female) from the Neuroscience in Psychiatry Network (NSPN) to investigate the impact of childhood abuse and neglect on resting-state network connectivity. Specifically, we examined the SAN, DMN, FPN, DAN, and VAN over time. We also explored the moderating role of positive parenting. The results showed that childhood abuse was linked to stronger connectivity within the SAN and VAN, as well as between the DMN-DAN, DMN-VAN, DMN-SAN, SAN-DAN, FPN-DAN, SAN-VAN, and VAN-DAN networks about 18 months later. Positive parenting during childhood buffered the negative impact of childhood abuse on network connectivity. To our knowledge, this is the first study to demonstrate the protective effect of positive parenting on network connectivity following childhood abuse. These findings not only highlight the importance of positive parenting but also lead to a better understanding of the neurobiology and resilience mechanisms of childhood maltreatment.
Effect of foreign direct investment on firms' pollution intensity: evidence from a natural experiment in China
Authors: Wang Xuefeng , Liu Haiyun
Published: April 2024

This paper examines a causal relationship between foreign direct investment (FDI) and firms' pollution intensity by exploiting the policy of China's FDI access relaxation in 2002. The result shows that FDI leads to a significant reduction in firms' pollution intensity. The mechanism tests find that FDI reduces pollution intensity by increasing firms' productivity, pollution management abilities, and the output of lightly polluting firms. The effect primarily acts on firms in lightly polluting industries and firms in the eastern region. The findings support the pollution halo hypothesis and provide implications for developing countries like China by evaluating the effectiveness of policies to attract FDI.
The Naqshbandiyya Mujaddidiyya in China
Authors: Thum Rian
Published: April 2024

The Naqshbandiyya Mujaddidiyya order is among the world's largest and most geographically widespread Sufi orders, but it has long been assumed to be absent among Chinese-speaking Muslims. Despite a handful of isolated references to local Chinese Mujaddidī groups in studies of particular communities, comprehensive histories of Chinese Islams make no mention of the Mujaddidiyya, and histories of the Naqshbandiyya Mujaddidiyya make no reference to Chinese-speaking Muslims. This article demonstrates that the Mujaddidiyya order has not only been present at various times and places among Chinese Muslims, but has also played a role in the development of nearly all major strains of Islam in China proper, including those commonly known as the Gedimu, Jahriyya, Khāfiyya, Qādiriyya, and Ikhwān. The article also uses new primary sources to provide an account of how a Mujaddidī order expanded into Eastern Turkistan and was transmitted from there to Muslims in China proper. It shows that adaptation to local environments created distinctive forms of Mujaddidī Sufism, highlights Hui-Uyghur connections, and argues that South Asia deserves a central place in any account of Islam in China.
Tongue edema as an adverse drug reaction to low-dose olanzapine in a cancer patient receiving palliative care
Authors: Moroni Matteo , Bruera Eduardo
Published: April 2024

Objectives

Olanzapine is an atypical neuroleptic indicated for treatment of various psychiatric disorders, but it has also several indications in palliative care (PC) patients: opioids misuse, nausea not related to chemotherapy, anorexia-cachexia syndrome, and sleep and mood disorders. Peripheral and facial edema are a rare side effect of the treatment with olanzapine. I report a case of an advanced cancer patient cared receiving PC who developed moderate tongue edema on day 1 of a low dose of olanzapine.

Methods

A patient with advance and metastatic colon cancer presented moderate tongue edema on day 1 of a low dose (2.5 mg) of olanzapine for the treatment of his nausea, anorexia-cachexia syndrome, and mood disorder (mainly anxiety).

Results

The patient discontinued the drug with resolution of the edema. The day after he called our outpatients’ service, a prompt physical examination, together with blood tests, excluded other differential diagnosis.

Significance of results

To the best of our knowledge, this is the second case reporting head and neck localized edema due to olanzapine treatment in a patient with advanced cancer receiving PC. Considering the increasing use of olanzapine as off-label treatment in these patients (often for cluster symptoms), our report could help clinicians in daily practice and researchers on put a deeper focus on indications for olanzapine in PC.
Medical marijuana laws and mental health in the United States
Authors: Kalbfuss Jörg , Odermatt Reto , Stutzer Alois
Published: April 2024

The consequences of legal access to medical marijuana for individuals' well-being are controversially assessed. We contribute to the discussion by evaluating the impact of the introduction of medical marijuana laws across US states on self-reported mental health considering different motives for cannabis consumption. Our analysis is based on BRFSS survey data from close to eight million respondents between 1993 and 2018 that we combine with information from the NSDUH to estimate individual consumption propensities. We find that eased access to marijuana through medical marijuana laws reduce the reported number of days with poor mental health for individuals with a high propensity to consume marijuana for medical purposes and for those individuals who likely suffer from frequent pain.
Alleviating the burden of depression: a simulation study on the impact of mental health services
Authors: Wilhelm M. , Bauer S. , Feldhege J. , Wolf M. , Moessner M.
Published: April 2024

Aims

Depressive disorders are ranked as the single leading cause of disability worldwide. Despite immense efforts, there is no evidence of a global reduction in the disease burden in recent decades. The aim of the study was to determine the public health impact of the current service system (status quo), to quantify its effects on the depression-related disease burden and to identify the most promising strategies for improving healthcare for depression on the population level.

Methods

A Markov model was developed to quantify the impact of current services for depression (including prevention, treatment and aftercare interventions) on the total disease burden and to investigate the potential of alternative scenarios (e.g., improved reach or improved treatment effectiveness). Parameter settings were derived from epidemiological information and treatment data from the literature. Based on the model parameters, 10,000,000 individual lives were simulated for each of the models, based on monthly transition rates between dichotomous health states (healthy vs. diseased). Outcome (depression-related disease burden) was operationalized as the proportion of months spent in depression.

Results

The current healthcare system alleviates about 9.5% (95% confidence interval [CI]: 9.2%–9.7%) of the total disease burden related to depression. Chronic cases cause the majority (83.2%) of depression-related burden. From a public health perspective, improving the reach of services holds the largest potential: Maximum dissemination of prevention (26.9%; CI: 26.7%–27.1%) and treatment (26.5%; CI: 26.3%–26.7%) would result in significant improvements on the population level.

Conclusions

The results confirm an urgent need for action in healthcare for depression. Extending the reach of services is not only more promising but also probably more achievable than increasing their effectiveness. Currently, the system fails to address the prevention and treatment of chronic cases. The large proportion of the disease burden associated with chronic courses highlights the need for improved treatment policies and clinical strategies for this group (e.g., disease management and adaptive or personalized interventions). The model complements the existing literature by providing a new perspective on the depression-related disease burden and the complex interactions between healthcare services and the lifetime course.
Public Responses to Unilateral Policymaking
Authors: Goehring Benjamin , Lowande Kenneth
Published: April 2024

Presidents possess vast authority over policies and outcomes. Recent studies suggest the public checks this unilateralism through expressive opinions and political participation. We reevaluate this accountability link with a preregistered panel survey that incorporates a number of design and conceptual improvements over existing experimental studies. Our findings reveal a more complex relationship between presidential actions and public opinion. We find no evidence that the public reacts negatively to unilateralism – and some evidence they react positively. Respondents, however, may punish an incumbent for failing to implement the proposed policy change. While such a result suggests that the public can hold presidents accountable, we close by discussing how a lack of information likely renders this check moot.
Stereotypes About Childfree Adults (SAChA)
Authors: Neal Jennifer Watling , Neal Zachary P.
Published: April 2024

Abstract: Childfree adults do not have or want children and voluntarily opt out of parenthood. Although this group is large (more than one-fifth of some adult populations), its members are often subjected to negative stereotypes about their behavior, obligations, personal characteristics, and future outcomes. These negative stereotypes are important because they have implications for childfree adults’ stigmatization. To help measure individuals’ stereotyped views of childfree adults, we use data on a representative sample of 1,000 Michigan adults to develop and validate the Stereotypes about Childfree Adults (SAChA) scale. We demonstrate that this four-item scale exhibits (1) high internal consistency, (2) scalar invariance with respect to sex, race/ethnicity, and education, and (3) known groups, convergent, and discriminant validity. We conclude by discussing potential applications of this scale for understanding stereotypes of individuals’ reproductive decisions.
Economic Development Drives Massive Global Estuarine Loss in the Anthropocene
Authors: Jung Nathalie W. , Lee Guan‐hong , Dellapenna Timothy M. , Jung Yoonho , Jo Tae‐Chang , Chang Jongwi , Figueroa Steven M.
Published: April 2024

Estuaries have great ecological and economic value and sustain both population and economic growth. Global‐scale analyses suggest that human activities drive estuarine area change but these projections neglect direct human‐estuary interactions and socio‐economic feedbacks. Here, we quantified area changes of 2,396 estuaries in response to recent human impacts (e.g., land reclamation, estuarine dam construction) and economic development between 1984 and 2019, and find that estuarine area shrank by 5,372 km2 whereas upland submergence created 5,015 km2 of estuarine area elsewhere. Approximately 44% (n = 1,046) of today's estuaries have been directly altered through land reclamation, estuarine dam construction, or a combination of both, and ∼250,000 acres (1,027 km2) of estuarine area have been directly converted to urban or agricultural fields. Nearly 90% (923 km2) of land reclamation occurred in Asia linked to recent advances in economic development during the middle‐income stage. Additional historical mapping and 5‐year interval analyses revealed that while human alterations were insignificant during the low‐income stages, estuaries were predominantly altered during their middle‐income stages, where estuarine degradation is a common consequence of economic growth. However, this trend stabilizes in high‐income countries with the adaption of conservation laws and policies. Together, our results indicate that large‐scale estuarine loss can be avoided by preserving estuaries in low‐ and mid‐income countries in the early stages of economic development.
Continental Hotspots Tracks From an Analysis of GOCE Gravity Gradients Data
Authors: Greff‐Lefftz Marianne , Panet Isabelle , Besse Jean
Published: April 2024

This study aims to detect residual thermal anomalies along the path of a hotspot beneath the continental lithosphere using gradiometry data. We calculate perturbations in gravity vectors and gradients by employing a simple thermal anomaly model. The results highlight that the horizontal components of Bouguer gravity gradients, sensitive to source structure and elongation, exhibit substantial magnitudes, exceeding current detection levels. To improve signals from sources of different sizes and orientations, we apply a filtering approach involving wavelet transforms and rotated local frames. We also assess the impact of lateral crustal variations on the gravity field by introducing random density anomalies and a seismic crustal model, testing the method's ability to distinguish between these anomalies and thermal sources. Using Gravity field and steady‐state Ocean Circulation Explorer satellite data, we generated scale‐orientation diagrams aiming to identify signals aligned with the direction of plate movement and with a spatial scale of a few hundred kilometers (scale of the plumes). Maps of filtered Bouguer gravity gradients aligned with hotspot trajectories are generated for all continental hot plumes, with the position and the age of the intraplate volcanism to support the interpretation. While we do not show a clear signal in regions that are too tectonically complex or with lateral variations in the crust or at the lithospheric boundary correlated with the hotspot trace, we found observed signals with expected sign and amplitude over Hoggar, Tibesti, Darfour and Cameroon tracks in Africa and over Iceland and Jan Mayen in Greenland. However, determining corresponding mass source depths remains a complex task.
Forward Modeling of 3‐D Ion Properties in Jupiter’s Magnetosphere Using Juno/JADE‐I Data
Authors: Wang Jian‐zhao , Bagenal Fran , Wilson Robert J. , Nerney Edward , Crary Frank , Dols Vincent , Ebert Rob W. , Valek Phil W. , Allegrini Frederic , Kim Thomas K. , Szalay Jamey R.
Published: April 2024

The Jovian Auroral Distributions Experiment Ion sensor (JADE‐I) on NASA’s Juno mission provides in‐situ measurements of ions from 0.1 to 46.2 keV/q inside Jupiter’s magnetosphere. JADE‐I is used to study the plasma with two types of datasets from the same measurement: Time‐of‐flight (TOF) and SPECIES. The TOF dataset provides mass‐per‐charge measurements with a range of 1–64 amu/q but oversamples particles over 6π steradian viewing per spacecraft spin and has little directional information. On the other hand, the SPECIES dataset can provide a good measurement of the flow direction but does not provide mass‐per‐charge information due to the telemetry limit. In this study, we developed a 2‐step forward modeling method that combines the advantages and avoids the disadvantages of TOF and SPECIES data to derive the 3‐D properties of heavy ions. Assuming that the ion velocity distribution can be described with the kappa distribution, we first perform the forward model fit of the TOF data to calculate the relative abundance of heavy ion species. Then we fix the relative abundance and perform the second forward model fit on the SPECIES data. Using this method, we obtain the densities of different heavy ions, the shared temperature and kappa value, and the 3‐D flow velocity vector. Some data examples of the equatorial plasma disk before Perijove 24 are included to demonstrate the method. Plasma properties can then be mapped to explore spatial and temporal variabilities in Jupiter’s magnetosphere.
Long‐Term Variability and Tendencies in Mesosphere and Lower Thermosphere Winds From Meteor Radar Observations Over Esrange (67.9°N, 21.1°E)
Authors: Ramesh K. , Mitchell Nicholas J. , Hindley Neil P. , Moffat‐Griffin Tracy
Published: April 2024

Long‐term variabilities of monthly zonal (U) and meridional winds (V) in northern polar mesosphere and lower thermosphere (MLT, ∼80–100 km) are investigated using meteor radar observations during 1999–2022 over Esrange (67.9°N, 21.1°E). The summer (June‐August) mean zonal winds are characterized by westward flow up to ∼88–90 km and eastward flow above this height. The summer mean meridional winds are equatorward with strong jet at ∼85–90 km and it weakens above this height. The U and V exhibit strong interannual variability that varies with altitude and month or season. The responses of U and V anomalies (from 1999 to 2003) to solar cycle (SC), Quasi Biennial Oscillation at 10 and 30 hPa, El Niño‐Southern Oscillation, North Atlantic Oscillation, ozone (O3) and carbon dioxide (CO2) are analyzed using multiple linear regression. From analysis, significant regions of correlations between MLT winds and above potential drivers vary with altitude and month. The positive responses of U and V to SC (up to 15 m/s/100 sfu) indicates the strengthening of eastward winds in mid‐late winter, and poleward winds in late autumn and early winter. The O3 likely intensifies the eastward and poleward winds (∼100 m/s/ppmv) in winter and early spring. The CO2 significantly influence the eastward flow in late winter and summer (above ∼90–95 km) and strengthen the meridional circulation. The significant positive trend in U peaks in summer, late autumn and early winter (∼0.6 m/s/year), the negative trend in V is more prominent in summer above ∼90–95 km.
The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis
Authors: Kumar Vikash , Sabaté-Cadenas Xavier , Soni Isha , Stern Esther , Vias Carine , Ginsberg Doron , Romá-Mateo Carlos , Pulido Rafael , Dodel Martin , Mardakheh Faraz K. , Shkumatava Alena , Shaulian Eitan
Published: April 2024

Cancer cells employ adaptive mechanisms to survive various stressors, including genotoxic drugs. Understanding the factors promoting survival is crucial for developing effective treatments. In this study, we unveil a previously unexplored long non-coding RNA, JUNI (JUN-DT, LINC01135), which is upregulated by genotoxic drugs through the activation of stress-activated MAPKs, JNK, and p38 and consequently exerts positive control over the expression of its adjacent gene product c-Jun, a well-known oncoprotein, which transduces signals to multiple transcriptional outputs. JUNI regulates cellular migration and has a crucial role in conferring cellular resistance to chemotherapeutic drugs or UV radiation. Depletion of JUNI markedly increases the sensitivity of cultured cells and spheroids to chemotherapeutic agents. We identified 57 proteins interacting with JUNI. The activity of one of them the MAPK phosphatase and inhibitor, DUSP14, is counteracted by JUNI, thereby, facilitating efficient JNK phosphorylation and c-Jun induction when cells are exposed to UV radiation. The antagonistic interplay with DUSP14 contributes not only to c-Jun induction but also augments the survival of UV-exposed cells. In summary, we introduce JUNI as a novel stress-inducible regulator of c-Jun, positioning it as a potential target for enhancing the sensitivity of cancer cells to chemotherapy.
Emerging racial disparities among Medicare beneficiaries and Veterans with metastatic castration-sensitive prostate cancer
Authors: George Daniel J. , Agarwal Neeraj , Ramaswamy Krishnan , Klaassen Zachary , Bitting Rhonda L. , Russell David , Sandin Rickard , Emir Birol , Yang Hongbo , Song Wei , Lin Yilu , Hong Agnes , Gao Wei , Freedland Stephen J.
Published: April 2024

Background

Previous studies have shown that Black men receive worse prostate cancer care than White men. This has not been explored in metastatic castration-sensitive prostate cancer (mCSPC) in the current treatment era.

Methods

We evaluated treatment intensification (TI) and overall survival (OS) in Medicare (2015–2018) and Veterans Health Administration (VHA; 2015–2019) patients with mCSPC, classifying first-line mCSPC treatment as androgen deprivation therapy (ADT) + novel hormonal therapy; ADT + docetaxel; ADT + first-generation nonsteroidal antiandrogen; or ADT alone.

Results

We analyzed 2226 Black and 16,071 White Medicare, and 1020 Black and 2364 White VHA patients. TI was significantly lower for Black vs White Medicare patients overall (adjusted odds ratio [OR] 0.68; 95% confidence interval [CI] 0.58–0.81) and without Medicaid (adjusted OR 0.70; 95% CI 0.57–0.87). Medicaid patients had less TI irrespective of race. OS was worse for Black vs White Medicare patients overall (adjusted hazard ratio [HR] 1.20; 95% CI 1.09–1.31) and without Medicaid (adjusted HR 1.13; 95% CI 1.01–1.27). OS was worse in Medicaid vs without Medicaid, with no significant OS difference between races. TI was significantly lower for Black vs White VHA patients (adjusted OR 0.75; 95% CI 0.61–0.92), with no significant OS difference between races.

Conclusions

Guideline-recommended TI was low for all patients with mCSPC, with less TI in Black patients in both Medicare and the VHA. Black race was associated with worse OS in Medicare but not the VHA. Medicaid patients had less TI and worse OS than those without Medicaid, suggesting poverty and race are associated with care and outcomes.
A therapist-administered self-report version of the Walking Index for Spinal Cord Injury II (WISCI): a psychometric study
Authors: Ben Marsha , Tamburella Federica , Lorusso Matteo , Glinsky Joanne V. , Tranter Keira E. , Scivoletto Giorgio , Blecher Lynn , Harris Anneliese , Galeoto Giovanni , Wan Joshua , Harvey Lisa A.
Published: April 2024

Objective

To develop a self-report version of the Walking Index for Spinal Cord Injury II (WISCI II) and to test its reliability and validity.

Study design

Psychometric study.

Setting

Spinal cord injury (SCI) rehabilitation centres in Australia and Italy.

Participants

Eighty people with SCI were recruited from a sample of convenience.

Methods

Two self-report versions of the WISCI II were developed. Both versions were administered in English at the Australian site, and in Italian at the Italian site through an online platform. The format of the first self-report version (SR-V1) was similar to the original face-to-face WISCI II. The second self-report version (SR-V2) had more questions, but each question required participants to focus on one aspect of walking at a time. Participants completed SR-V1 and SR-V2 with assistance from research physiotherapists on two separate occasions, three to seven days apart. The original WISCI II was then administered through a face-to-face assessment by an independent physiotherapist. The intra-rater reliability and validity of SR-V1 and SR-V2 were determined with intraclass correlation coefficients (ICC) and percent close agreements.

Results

The data from the Australian and Italian sites were pooled. The validity and reliability of the two self-report versions were very similar, with SR-V2 performing slightly better than SR-V1. The ICC (95% confidence interval) of SR-V2 was 0.87 (0.81–0.92). The ICC reflecting the agreement between the self-report and the face-to-face WISCI was 0.89 (0.84–0.93).

Conclusion

Both versions of the self-report WISCI II provide a reasonable substitute for a face-to-face assessment although therapists preferred SR-V2.
Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth
Authors: Furukawa Natsuki , Yang Wendy , Chao Alex R. , Patil Akash , Mirando Adam C. , Pandey Niranjan B. , Popel Aleksander S.
Published: April 2024

Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1-treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 functions as an oncolytic peptide and has a therapeutic potential to treat cancer.
Dupilumab-associated head and neck dermatitis shows a pronounced type 22 immune signature mediated by oligoclonally expanded T cells
Authors: Bangert Christine , Alkon Natalia , Chennareddy Sumanth , Arnoldner Tamara , Levine Jasmine P. , Pilz Magdalena , Medjimorec Marco A. , Ruggiero John , Cohenour Emry R. , Jonak Constanze , Damsky William , Griss Johannes , Brunner Patrick M.
Published: April 2024

Dupilumab, an IL4R-blocking antibody, has shown clinical efficacy for atopic dermatitis (AD) treatment. In addition to conjunctivitis/blepharitis, the de novo appearance of head/neck dermatitis is now recognized as a distinct side effect, occurring in up to 10% of patients. Histopathological features distinct from AD suggest a drug effect, but exact underlying mechanisms remain unknown. We profiled punch biopsies from dupilumab-associated head and neck dermatitis (DAHND) by using single-cell RNA sequencing and compared data with untreated AD and healthy control skin. We show that dupilumab treatment was accompanied by normalization of IL-4/IL-13 downstream activity markers such as CCL13, CCL17, CCL18 and CCL26. By contrast, we found strong increases in type 22-associated markers (IL22, AHR) especially in oligoclonally expanded T cells, accompanied by enhanced keratinocyte activation and IL-22 receptor upregulation. Taken together, we demonstrate that dupilumab effectively dampens conventional type 2 inflammation in DAHND lesions, with concomitant hyperactivation of IL22-associated responses.
Maternal hybrid immunity and risk of infant COVID-19 hospitalizations: national case-control study in Israel
Authors: Guedalia Joshua , Lipschuetz Michal , Cahen-Peretz Adva , Cohen Sarah M. , Sompolinsky Yishai , Shefer Galit , Melul Eli , Ergaz-Shaltiel Zivanit , Goldman-Wohl Debra , Yagel Simcha , Calderon-Margalit Ronit , Beharier Ofer
Published: April 2024

Hybrid immunity, acquired through vaccination followed or preceded by a COVID-19 infection, elicits robust antibody augmentation. We hypothesize that maternal hybrid immunity will provide greater infant protection than other forms of COVID-19 immunity in the first 6 months of life. We conducted a case-control study in Israel, enrolling 661 infants up to 6 months of age, hospitalized with COVID-19 (cases) and 59,460 age-matched non-hospitalized infants (controls) between August 24, 2021, and March 15, 2022. Infants were grouped by maternal immunity status at delivery: Naïve (never vaccinated or tested positive, reference group), Hybrid-immunity (vaccinated and tested positive), Natural-immunity (tested positive before or during the study period), Full-vaccination (two-shot regimen plus 1 booster), and Partial-vaccination (less than full three shot regimen). Applying Cox proportional hazards models to estimate the hazard ratios, which was then converted to percent vaccine effectiveness, and using the Naïve group as the reference, maternal hybrid-immunity provided the highest protection (84% [95% CI 75-90]), followed by full-vaccination (66% [95% CI 56-74]), natural-immunity (56% [95% CI 39-68]), and partial-vaccination (29% [95% CI 15-41]). Maternal hybrid-immunity was associated with a reduced risk of infant hospitalization for Covid-19, as compared to natural-immunity, regardless of exposure timing or sequence. These findings emphasize the benefits of vaccinating previously infected individuals during pregnancy to reduce COVID-19 hospitalizations in early infancy.
Northeast Pacific warm blobs sustained via extratropical atmospheric teleconnections
Authors: Shi Jian , Huang Hao , Fedorov Alexey V. , Holbrook Neil J. , Zhang Yu , Ding Ruiqiang , Luo Yongyue , Wang Shengpeng , Chen Jiajie , Hu Xi , Liu Qinyu , Huang Fei , Lin Xiaopei
Published: April 2024

Large-scale marine heatwaves in the Northeast Pacific (NEP), identified here and previously as ‘warm blobs’, have devastating impacts on regional ecosystems. An anomalous atmospheric ridge over the NEP is known to be crucial for maintaining these warm blobs, also causing abnormally cold temperatures over North America during the cold season. Previous studies linked this ridge to teleconnections from tropical sea surface temperature anomalies. However, it was unclear whether teleconnections from the extratropics could also contribute to the ridge. Here we show that planetary wave trains, triggered by increased rainfall and latent heat release over the Mediterranean Sea accompanied by decreased rainfall over the North Atlantic, can transport wave energy to the NEP, guided by the westerly jet, and induce a quasi-barotropic ridge there. Our findings provide insights into extratropical teleconnections sustaining the NEP ridge, offering a source of potential predictability for the warm blobs and temperature fluctuations over North America.
Biomimetic NIR-II fluorescent proteins created from chemogenic protein-seeking dyes for multicolor deep-tissue bioimaging
Authors: Xu Jiajun , Zhu Ningning , Du Yijing , Han Tianyang , Zheng Xue , Li Jia , Zhu Shoujun
Published: April 2024

Near-infrared-I/II fluorescent proteins (NIR-I/II FPs) are crucial for in vivo imaging, yet the current NIR-I/II FPs face challenges including scarcity, the requirement for chromophore maturation, and limited emission wavelengths (typically < 800 nm). Here, we utilize synthetic protein-seeking NIR-II dyes as chromophores, which covalently bind to tag proteins (e.g., human serum albumin, HSA) through a site-specific nucleophilic substitution reaction, thereby creating proof-of-concept biomimetic NIR-II FPs. This chemogenic protein-seeking strategy can be accomplished under gentle physiological conditions without catalysis. Proteomics analysis identifies specific binding site (Cys 477 on DIII). NIR-II FPs significantly enhance chromophore brightness and photostability, while improving biocompatibility, allowing for high-performance NIR-II lymphography and angiography. This strategy is universal and applicable in creating a wide range of spectrally separated NIR-I/II FPs for real-time visualization of multiple biological events. Overall, this straightforward biomimetic approach holds the potential to transform fluorescent protein-based bioimaging and enables in-situ albumin targeting to create NIR-I/II FPs for deep-tissue imaging in live organisms.
Ultrafast photoinduced C-H bond formation from two small inorganic molecules
Authors: Jiang Zhejun , Huang Hao , Lu Chenxu , Zhou Lianrong , Pan Shengzhe , Qiang Junjie , Shi Menghang , Ye Zhengjun , Lu Peifen , Ni Hongcheng , Zhang Wenbin , Wu Jian
Published: April 2024

The formation of carbon-hydrogen (C-H) bonds via the reaction of small inorganic molecules is of great significance for understanding the fundamental transition from inorganic to organic matter, and thus the origin of life. Yet, the detailed mechanism of the C-H bond formation, particularly the time scale and molecular-level control of the dynamics, remain elusive. Here, we investigate the light-induced bimolecular reaction starting from a van der Waals molecular dimer composed of two small inorganic molecules, H2 and CO. Employing reaction microscopy driven by a tailored two-color light field, we identify the pathways leading to C-H photobonding thereby producing HCO+ ions, and achieve coherent control over the reaction dynamics. Using a femtosecond pump-probe scheme, we capture the ultrafast formation time, i.e., 198 ± 16 femtoseconds. The real-time visualization and coherent control of the dynamics contribute to a deeper understanding of the most fundamental bimolecular reactions responsible for C–H bond formation, thus contributing to elucidate the emergence of organic components in the universe.