bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Theoretical Study of D–A–π–A Organic Sensitizers with [1,2,5]Thiadiazolo[3,4-c]pyridine, [1,2,5]Selenadiazolo[3,4-c]pyridine, and [1,2,5]Oxadiazolo[3,4-c]pyridineπComponent
Authors: Bolshakov O. I. , Grishina M. A. , Galushko A. , Potemkin V. A. , Rakitin O. A.
Published: December 2015

The study concerns molecular design and theoretical study of novel prospective organic sensitizers based on D–A–π–A concept. A modification of the concept (DA–π–A) and new ways for design of organic sensitizers are proposed. The study shows thatπ-block plays a key role for the wavelength shift in UV-Vis spectra. An existence of element of higher periods in theπ-block provides a noticeable bathochromic shift. The thienyl bridge in A-block provides a red shift with respect to phenyl bridge for[1,2,5]oxadiazolo[3,4-c]pyridines while the phenyl bridge provides a red shift with respect to thienyl bridge for[1,2,5]selenadiazolo[3,4-c]pyridines. The maximal wavelengths are observed for DA-blocks with aliphatic/alicyclic fragments we proposed. An influence of enthalpy of formation and polarity of DA-blocks on bathochromic shift is shown. The quantitative dependencies of wavelengths on the enthalpies and dipole moments are determined. The maximal oscillator strengths are observed for the planar DA-block. Therefore, the conditions for design of compounds possessing the maximal wavelengths and oscillator strengths are different: the latter presupposes the planar structure of DA-block while the first presupposes an existence of nonplanar aliphatic/alicyclic fragments. Thus, the further design of organic sensitizers should include some combination of these concepts.
Outcomes of Intracytoplasmic Sperm Injection Cycles for Complete Teratozoospermia: A Case-Control Study Using Paired Sibling Oocytes
Authors: Pereira Nigel , Neri Queenie V. , Lekovich Jovana P. , Spandorfer Steven D. , Palermo Gianpiero D. , Rosenwaks Zev
Published: December 2015

Objective. To investigate the outcomes of intracytoplasmic sperm injection (ICSI) cycles where sibling oocytes from a single donor were split between two recipients based on strict sperm morphology.Methods. Retrospective cohort study. All ICSI cycles had one donor’s oocytes split between two recipients in a 1 : 1 ratio based on strict sperm morphology, that is, one male partner had morphology of 0% and the other had morphology of >1%. Fertilization, positive hCG, clinical pregnancy, spontaneous miscarriage, and live birth rates of the aforementioned groups were compared.Results. The baseline characteristics of the two groups (n=103), including semen parameters of the male partners, were comparable. There was no difference in the fertilization rates when comparing the 0% group to the >1% group (78.7% versus 81.6%;P=0.66). The overall positive hCG, clinical pregnancy, spontaneous miscarriage, and live birth rates for the 0% group were 61.2%, 49.5%, 10.7%, and 38.8%, respectively. The corresponding rates in the >1% group were positive hCG (63.1%), clinical pregnancy (55.3%), spontaneous miscarriage (7.77%), and live birth (46.6%).Conclusions. The fertilization and pregnancy outcomes of ICSI cycles for strict sperm morphology of 0% versus morphology of >1% are equivalent. These results can provide reassurance to couples undergoing ICSI for severe teratospermia.
An Analysis of Physician Productivity and Self-Sustaining Revenue Generation in a Free-Standing Emergency Department Medical Scribe Model
Authors: Dawkins Brody , Bhagudas Komal N. , Hurwitz Joshua , Tyndall J. Adrian , Guerra Marcelo E. , Falgiani Michael , Payton Thomas F. , Allen Brandon R.
Published: December 2015

Objectives. A free-standing emergency department (FSED) is a facility that provides comprehensive emergency medical care similar to a traditional emergency department but is not attached to a hospital campus. Medical scribes are increasingly likely to work in free-standing emergency departments. The purpose of this study was to retrospectively investigate the benefits of a scribe program in an FSED. Methods. A retrospective, Institutional Review Board-approved analysis from December 1, 2013, to February 1, 2015, of free-standing emergency department medical data was extracted to determine if scribed charts resulted in increased revenue and improved throughput. Results. When scribes are present in the FSED there is a small, but statistically significant, decrease in time from patient arrival to provider by 2.74 minutes. Scribed charts collected $4.69 more per chart and resulted in an increase in productivity. Incremental cost effectiveness ratios resulted in proven cost-utility with a net-positive effect. Conclusion. While there are some gains in terms of operational metrics and provider productivity with the addition of scribes to a free-standing emergency department, there is a net-positive financial impact of scribes. Implementing a scribe program at a FSED is cost-effective and justified from both an operational and a financial analysis.
Humoral Immunity in Bronchiectasis: Finding Good’s Syndrome
Authors: Pu C. , Sukhal S. , Fakhran S.
Published: December 2015

We present a case of a 37-year-old man with a past history of a surgically removed thymoma, who presented with recurrent pulmonary infections and bronchiectasis. On further testing, he was found to have low total immunoglobulin levels, a constellation of findings known as Good’s syndrome. He responded well to immunoglobulin replacement, in addition to the usual treatments for bronchiectasis. We present this case to emphasize the association of bronchiectasis, low immunoglobulins, and thymomas and the role of immunoglobulin replacement as a treatment option.
Workplace Based Assessment in an Asian Context: Trainees’ and Trainers’ Perception of Validity, Reliability, Feasibility, Acceptability, and Educational Impact
Authors: Tan Jackson , Tengah Connie , Chong Vui Heng , Liew Adrian , Naing Lin
Published: December 2015

Workplace based assessment (WPBA) is commonplace in postgraduate training in many countries but is not widely practised and established in Asia. The WPBA tools that are used by the local programme are Mini-Clinical Examination (Mini-CEX), Directly Observed Practical Skills (DOPSs), Multisource Feedback (MSF), and Case Based Discussion (CBD). This cross-sectional study utilised a questionnaire to obtain feedback from both assessors and trainees. Participants rated the tools on a 5-point scale on validity, reliability, feasibility, educational impact, and acceptability. 30 assessors and 23 trainees participated in the study. The percentages of adequate ratings given by trainees for validity, reliability, feasibility, educational impact, and acceptability were 100%, 99%, 91%, 100%, and 100%, respectively, for all tools. There was no difference in perceptions between trainees and assessors for all WPBA tools except MSF (p<0.05). The common themes that have arisen suggested that applicability of WPBA could be affected by faculty development, endorsement from governing bodies, pervading cultural mindsets, and the complex relationships between doctors and patients; teachers and students; and educators and clinicians. The high level of satisfaction from our respondents indicates that WPBA can be successfully integrated in an Asian postgraduate training programme despite systemic, cultural, and language barriers.
Evidence-Based Treatments for Adults with Migraine
Authors: Gooriah Rubesh , Nimeri Randa , Ahmed Fayyaz
Published: December 2015

Migraine, a significantly disabling condition, is treated with acute and preventive medications. However, some individuals are refractory to standard treatments. Although there is a host of alternative management options available, these are not always backed by strong evidence. In fact, most of the drugs used in migraine were initially designed for other purposes. Whilst effective, the benefits from these medications are modest, reflecting the need for newer and migraine-specific therapeutic agents. In recent years, we have witnessed the emergence of novel treatments, of which noninvasive neuromodulation appears to be the most attractive given its ease of use and excellent tolerability profile. This paper reviews the evidence behind the available treatments for migraine.
SnO2Nanostructure as Pollutant Gas Sensors: Synthesis, Sensing Performances, and Mechanism
Authors: Yuliarto Brian , Gumilar Gilang , Septiani Ni Luh Wulan
Published: December 2015

A significant amount of pollutants is produced from factories and motor vehicles in the form of gas. Their negative impact on the environment is well known; therefore detection with effective gas sensors is important as part of pollution prevention efforts. Gas sensors use a metal oxide semiconductor, specifically SnO2nanostructures. This semiconductor is interesting and worthy of further investigation because of its many uses, for example, as lithium battery electrode, energy storage, catalyst, and transistor, and has potential as a gas sensor. In addition, there has to be a discussion of the use of SnO2as a pollutant gas sensor especially for waste products such as CO, CO2, SO2, and NOx. In this paper, the development of the fabrication of SnO2nanostructures synthesis will be described as it relates to the performances as pollutant gas sensors. In addition, the functionalization of SnO2as a gas sensor is extensively discussed with respect to the theory of gas adsorption, the surface features of SnO2, the band gap theory, and electron transfer.
Antibacterial Effect and Physical-Mechanical Properties of Temporary Restorative Material Containing Antibacterial Agents
Authors: Mushashe Amanda Mahammad , Gonzaga Carla Castiglia , Tomazinho Paulo Henrique , da Cunha Leonardo Fernandes , Leonardi Denise Piotto , Pissaia Janes Francio , Correr Gisele Maria
Published: December 2015

Introduction. For the maintenance of the aseptic chain created during the treatment the coronal sealing becomes paramount. Aim. Evaluating the antibacterial effect and the physical-mechanical properties of a temporary restorative material containing different antibacterial agents. Material and Methods. Two antibacterial agents (triclosan and chloramine T) were manually added to a temporary restorative material used as base (Coltosol). The antibacterial action of the material was analyzed using the agar diffusion method, in pure cultures of Escherichia coli (ATCC BAA-2336) and Staphylococcus aureus (ATCC 11632) and mixed culture of saliva collection. The microleakage rate was analyzed using bovine teeth, previously restored with the materials, and submitted to thermocycling, in a solution of 0.5% methylene blue, for a period of 24 hours. The physical and mechanical properties of the materials analyzed were setting time, water sorption, solubility, and compression strength. Results. No marginal leakage was observed for all groups. There was no statistical significant difference in antimicrobial activity, setting time, water sorption, solubility, and compression strength among the materials. Conclusion. The addition of antibacterial agents on a temporary restorative material did not optimize the antibacterial ability of the material and also did not change its physical-mechanical properties.
The Optical Properties of Crystalline Zn3Nb2O8Nanomaterials Obtained by Hydrothermal Method
Authors: Birdeanu Mihaela , Vaida Mirela , Fagadar-Cosma Eugenia
Published: December 2015

The present study is focused on the obtaining of the Zn3Nb2O8nanomaterial using the hydrothermal method and its characterization through different techniques. X-ray diffraction at room temperature revealed that a novel crystalline form of the nanomaterial forms at 1100°C belonging to monoclinic space group C2/c. Field-emission scanning electron microscopy evidenced the columnar morphology of the particle’s agglomeration and the high resolution electron transmission microscopy confirms the measured interplanar distances calculated from the X-ray diffraction experiments. Using the UV-VIS spectrum and Kubelka-Munk equations, the absorbance and the band gap for the Zn3Nb2O8nanomaterial were calculated. PL spectrum reveals a single peak at 465 nm corresponding to the blue color fluorescence. The novel crystalline nanomaterial might find applications in fluorescence covering of technical devices, due to its capacity to preserve blue fluorescence both in acrylic based paint and after embedding in isopropyl alcohol.
Generalized Variability Orderings among Nonnegative Fuzzy Random Variables
Authors: Ramasubramanian S. , Mahendran P.
Published: December 2015

The variability ordering for more and less variables of fuzzy random variables in terms of its distribution function is defined. A property of new better than used in expectation (NBUE) and new worse than used in expectation (NWUE) is derived as an application to the variability ordering of fuzzy random variables. The concept of generalized variability orderings of nonnegative fuzzy random variables representing lifetime of components is introduced. The<Pdomination is a generalized variability ordering. We proposed an integral inequality to the case of fuzzy random variables using<Pordering. The results included equivalent conditions which justify the generalized variability orderings.
SimFuse: A Novel Fusion Simulator for RNA Sequencing (RNA-Seq) Data
Authors: Tan Yuxiang , Tambouret Yann , Monti Stefano
Published: December 2015

The performance evaluation of fusion detection algorithms from high-throughput sequencing data crucially relies on the availability of data with known positive and negative cases of gene rearrangements. The use of simulated data circumvents some shortcomings of real data by generation of an unlimited number of true and false positive events, and the consequent robust estimation of accuracy measures, such as precision and recall. Although a few simulated fusion datasets from RNA Sequencing (RNA-Seq) are available, they are of limited sample size. This makes it difficult to systematically evaluate the performance of RNA-Seq based fusion-detection algorithms. Here, we present SimFuse to address this problem. SimFuse utilizes real sequencing data as the fusions’ background to closely approximate the distribution of reads from a real sequencing library and uses a reference genome as the template from which to simulate fusions’ supporting reads. To assess the supporting read-specific performance, SimFuse generates multiple datasets with various numbers of fusion supporting reads. Compared to an extant simulated dataset, SimFuse gives users control over the supporting read features and the sample size of the simulated library, based on which the performance metrics needed for the validation and comparison of alternative fusion-detection algorithms can be rigorously estimated.
Evaluation of Intrastromal Riboflavin Concentration in Human Corneas after Three Corneal Cross-Linking Imbibition Procedures: A Pilot Study
Authors: Franch Antonella , Birattari Federica , Dal Mas Gloria , Lužnik Zala , Parekh Mohit , Ferrari Stefano , Ponzin Diego
Published: December 2015

Purpose. To compare stromal riboflavin concentration after three corneal cross-linking (CXL) imbibition procedures: standard (EpiOff), transepithelial corneal (EpiOn), and iontophoresis-assisted technique (Ionto) using 0.1% hypotonic riboflavin phosphate.Methods. Randomized open-label pilot clinical study. Twelve corneas/12 patients with advanced keratoconus were randomly divided into 4 groups for CXL (n=3). The corneas underwent imbibition with standard riboflavin EpiOff and with enhanced riboflavin solution (RICROLIN+) EpiOff, EpiOn, and iontophoresis techniques. Thereafter, deep anterior lamellar keratectomy procedure was performed and the obtained debrided corneal tissues were frozen. The maximal intrastromal riboflavin concentration was measured by high-performance liquid chromatography/mass spectrometry (mcg/dg).Results. The mean stromal concentration of riboflavin was2.02±0.72mcg/dg in EpiOff group,4.33±0.12mcg/g in EpiOff-RICROLIN+ group,0.63±0.21mcg/dg in EpiOn-RICROLIN+ group, and1.15±0.27mcg/dg in iontophoresis RICROLIN+ group. A 7-fold decrease in intrastromal riboflavin concentration was observed comparing EpiOn-RICROLIN+ and EpiOff-RICROLIN+ groups.Conclusion. The present pilot study indicates that both transepithelial CXL techniques in combination with hypotonic enhanced riboflavin formulation (RICROLIN+) were still inferior to the standard CXL technique; however, larger clinical studies to further validate the results are needed and in progress.
Long Read Alignment with Parallel MapReduce Cloud Platform
Authors: Al-Absi Ahmed Abdulhakim , Kang Dae-Ki
Published: December 2015

Genomic sequence alignment is an important technique to decode genome sequences in bioinformatics. Next-Generation Sequencing technologies produce genomic data of longer reads. Cloud platforms are adopted to address the problems arising from storage and analysis of large genomic data. Existing genes sequencing tools for cloud platforms predominantly consider short read gene sequences and adopt the Hadoop MapReduce framework for computation. However, serial execution of map and reduce phases is a problem in such systems. Therefore, in this paper, we introduce Burrows-Wheeler Aligner’s Smith-Waterman Alignment on Parallel MapReduce (BWASW-PMR) cloud platform for long sequence alignment. The proposed cloud platform adopts a widely accepted and accurate BWA-SW algorithm for long sequence alignment. A custom MapReduce platform is developed to overcome the drawbacks of the Hadoop framework. A parallel execution strategy of the MapReduce phases and optimization of Smith-Waterman algorithm are considered. Performance evaluation results exhibit an average speed-up of 6.7 considering BWASW-PMR compared with the state-of-the-art Bwasw-Cloud. An average reduction of 30% in the map phase makespan is reported across all experiments comparing BWASW-PMR with Bwasw-Cloud. Optimization of Smith-Waterman results in reducing the execution time by 91.8%. The experimental study proves the efficiency of BWASW-PMR for aligning long genomic sequences on cloud platforms.
One and Multiple Bonds Interatomic Spin-Spin Coupling inη6-Cymene Ru(II) of 3,5-Dimethyl-, 3,5-Dicarboxylic-, and 5-Phenyl-pyrazole Derivatives
Authors: Adeniyi Adebayo A. , Ajibade Peter A.
Published: December 2015

The changes in the interatomic distances and the corresponding spin-spin coupling as a result of the hydrolysis of the ruthenium complexes and the effects of different derivatives of the pyrazole ligands and the substituents methyl, carboxylic, and phenyl on the pyrazole rings were studied. A good agreement was obtained between the experimental and the theoretical proton NMR. Significant changes are observed in the isotropic and anisotropic shielding tensor of the atoms and related spin-spin coupling of their bonds due to hydrolysis of the complexes. This observation gives more insight into the known mechanism of activation of the ruthenium complexes by hydrolysis. There are no direct effects of interatomic distances on many of the computed spin-spin couplings with the exception of1J(Ru-N) which shows significant changes especially within the pair of1J(Ru-N) in the complexes with two nitrogen atoms of the bis-pyrazole moiety. The magnitude of interatomic spin-spin coupling of the Ru-X follows the order of Ru-Cl > Ru-N > Ru-C > Ru-O. The Ramsey term Fermi contact (FC) has the most significant contribution in most of the computed spin-spin interactions except in1J(Ru-Cl) and1J(N-N⁎) which are predominantly defined by the contribution from the paramagnetic spin orbit (PSO).
Prostatic Stromal Tumor of Uncertain Malignant Potential Which Was Difficult to Diagnose
Authors: Matsuyama Satoko , Nohara Takahiro , Kawaguchi Shohei , Seto Chikashi , Nakanishi Yuko , Uchiyama Akio , Ishizawa Shin
Published: December 2015

Here, we report a case of stromal tumor of uncertain malignant potential (STUMP) that was difficult to diagnose. A 53-year-old male was found to have a hard nodule on digital rectal examination; magnetic resonance imaging revealed a large nodule on the left side of the prostate, indicating prostate cancer. However, pathological diagnosis of the biopsy specimen was benign prostatic hyperplasia. Although a papillary tumor in the prostatic urethra was also seen on urethrocystoscopy, the tumor specimen obtained from transurethral resection was not malignant. The tumor in the prostatic urethra recurred only 3 months after transurethral resection, and pathological findings revealed benign hyperplasia not only in the stromal tissue but also in the epithelium; therefore, the prostate tumor was suspected to be STUMP. It took many prostate pathologists a long time to reach the final diagnosis of STUMP. STUMP is a rare benign tumor, difficult to diagnose, and sometimes transforms into stromal sarcoma. Thus, we should consider radical resection in such cases.
Development and Validation of an HPLC Method for Simultaneous Quantification of Clopidogrel Bisulfate, Its Carboxylic Acid Metabolite, and Atorvastatin in Human Plasma: Application to a Pharmacokinetic Study
Authors: Croitoru Octavian , Spiridon Adela-Maria , Belu Ionela , Turcu-Ştiolică Adina , Neamţu Johny
Published: December 2015

A simple, sensitive, and specific reversed phase liquid chromatographic method was developed and validated for simultaneous quantification of clopidogrel, its carboxylic acid metabolite, and atorvastatin in human serum. Plasma samples were deproteinized with acetonitrile and ibuprofen was chosen as internal standard. Chromatographic separation was performed on an BDS HypersilC18column (250 × 4.6 mm; 5 μm) via gradient elution with mobile phase consisting of 10 mM phosphoric acid (sodium) buffer solution (pH = 2.6 adjusted with 85% orthophosphoric acid) : acetonitrile : methanol with flow rate of 1 mL·min−1. Detection was achieved with PDA detector at 220 nm. The method was validated in terms of linearity, sensitivity, precision, accuracy, limit of quantification, and stability tests. Calibration curves of the analytes were found to be linear in the range of 0.008–2 μg·mL−1for clopidogrel, 0.01–4 μg·mL−1for its carboxylic acid metabolite, and 0.005–2.5 μg·mL−1for atorvastatin. The results of accuracy (as recovery) with ibuprofen as internal standard were in the range of 96–98% for clopidogrel, 94–98% for its carboxylic acid metabolite, and 90–99% for atorvastatin, respectively.
Reporting Melanoma: A Nationwide Surveillance of State Cancer Registries
Authors: Raji Kehinde O. , Payne Lauren , Chen Suephy C.
Published: December 2015

The goal of our study was to determine current melanoma reporting methods available to dermatologists and dermatopathologists and quantify changes in reporting methods from 2012 to 2014. A cross-sectional study design was utilized consisting of website perusal of reporting procedures, followed up by telephone and email inquiry of reporting methods from every state cancer registry. This study was conducted over a six-month period from February to August 2014. A previous similar survey was conducted in 2012 over the same time frame and results were compared. Kansas state cancer registry provided no data. As of August 2014, 96% of 49 state cancer registries had electronic methods available to all designated reporters. Seven (14%) states required an electronic-only method of reporting melanoma cases. Eighty-six percent allowed hard copy pathology report submission. Compared to the 2012 survey, 2 additional states were found to have initiated electronic reporting methods by 2014. In conclusion, a variety of methods exist for reporting diagnosed melanoma cases. Although most state cancer registries were equipped for electronic transmission of cases for mandated reporters, a number of states were ill-equipped for electronic submission from outpatient dermatologists. There was a general trend towards electronic versus nonelectronic reporting from 2012 to 2014.
Seasonal Temperature Changes Do Not Affect Cardiac Glucose Metabolism
Authors: Schildt Jukka , Loimaala Antti , Hippeläinen Eero , Nikkinen Päivi , Ahonen Aapo
Published: December 2015

FDG-PET/CT is widely used to diagnose cardiac inflammation such as cardiac sarcoidosis. Physiological myocardial FDG uptake often creates a problem when assessing the possible pathological glucose metabolism of the heart. Several factors, such as fasting, blood glucose, and hormone levels, influence normal myocardial glucose metabolism. The effect of outdoor temperature on myocardial FDG uptake has not been reported before. We retrospectively reviewed 29 cancer patients who underwent PET scans in warm summer months and again in cold winter months. We obtained myocardial, liver, and mediastinal standardized uptake values (SUVs) as well as quantitative cardiac heterogeneity and the myocardial FDG uptake pattern. We also compared age and body mass index to other variables. The mean myocardial FDG uptake showed no significant difference between summer and winter months. Average outdoor temperature did not correlate significantly with myocardial SUVmax in either summer or winter. The heterogeneity of myocardial FDG uptake did not differ significantly between seasons. Outdoor temperature seems to have no significant effect on myocardial FDG uptake or heterogeneity. Therefore, warming the patients prior to attending cardiac PET studies in order to reduce physiological myocardial FDG uptake seems to be unnecessary.
Effect of Bleaching and Thermocycling on Resin-Enamel Bond Strength
Authors: Moosavi Horieh , Mohammadipour Hamideh Sadat , Ghavamnasiri Marjaneh , Alizadeh Sanaz
Published: December 2015

The aim of this study was to evaluate the effect of bleaching and thermocycling on microshear bond strength of bonded resin composites to enamel. Enamel slices were prepared from ninety-six intact human premolars and resin composite cylinders were bonded by using Adper Single Bond 2 + Filtek Z350 or Filtek silorane adhesive and resin composite. Each essential group was randomly subdivided to two subgroups: control and bleaching. In bleaching group, 35% hydrogen peroxide was applied on samples. Thermocycling procedure was conducted between 5°C and 55°C, for 3.000 cycles on the half of each subgroup specimen. Then microshear bond strength was tested. Methacrylate-based resin composite had higher bond strength than silorane-based one. The meyhacrylate-based group without bleaching along with thermocycling showed the most bond strength, while bleaching with 35% carbamide peroxide on silorane-based group without thermocycling showed the least microshear bond strength. Bleaching caused a significant degradation on shear bond strength of silorane-based resin composites that bonded using self-etch adhesive resin systems.
Estimation of the Reception Angle Distribution Based on the Power Delay Spectrum or Profile
Authors: Ziółkowski Cezary , Kelner Jan M.
Published: December 2015

The paper presents an estimation of the reception angle distribution based on temporal characteristics such as the power delay spectrum (PDS) or power delay profile (PDP). Here, we focus on such wireless environment, where the propagation phenomenon predominates in azimuth plane. As a basis to determine probability density function (PDF) of the angle of arrival (AOA), a geometrical channel model (GCM) in form of the multielliptical model for delayed scattering components and the von Mises’ PDF for local scattering components are used. Therefore, this estimator is called the distribution based on multielliptical model (DBMM). The parameters of GCM are defined on the basis of the PDS or PDP and the relative position of the transmitter and the receiver. In contrast to the previously known statistical models, DBMM ensures the estimation PDF of AOA by using the temporal characteristics of the channel for differing propagation conditions. Based on the results of measurements taken from the literature, DBMM verification, assessment of accuracy, and comparison with other models are shown. The results of comparison show that DBMM is the only model that provides the smallest least-squares error for different environments.
Bilateral Bronchiectasis as a Presentation Form of Pulmonary Marginal Zone B-Cell Lymphoma of Bronchus Associated Lymphoid Tissue
Authors: Ernst Glenda , Torres Carla , Borsini Eduardo , Vigovich Félix , Downey Daniel , Salvado Alajandro , Bosio Martín
Published: December 2015

The pulmonary marginal zone B-cell lymphoma of bronchus associated lymphoid tissue of the lung (BALT) is a rare illness that can remain without symptoms. Radiological findings of pulmonary lymphoma are heterogeneous. In literature, bronchiectasis is only described in one patient who also had besides adenomegalies. We reported on a 48-year-old female patient. She showed symptoms consistent with dyspnea with productive cough; there were crepitant sounds in the auscultation. Pulmonary functional test has shown a severe restrictive pattern with a low FVC and DLCO. CT scan showed bronchiectasis in the medium lobule without adenomegalies. Echocardiogram was normal, and the laboratory findings only showed leukocytosis. There were no findings in the bronchoscopy, but the lung biopsy showed a B-cell pulmonary lymphoma (positive to CD20 and CD79a in immunostaining). A wide variety of radiological manifestations has been previously described; however, we have presented this rare case, with bronchiectasis, as unique radiological finding.
Blood Glucose Fluctuations in Type 2 Diabetes Patients Treated with Multiple Daily Injections
Authors: Li Feng-fei , Fu Li-yuan , Zhang Wen-li , Su Xiao-fei , Wu Jin-dan , Sun Jin , Ye Lei , Ma Jian-hua
Published: December 2015

To compare blood glucose fluctuations in type 2 diabetes mellitus (T2DM) patients were treated using three procedures: insulin intensive therapy which is continuous subcutaneous insulin infusion (CSII), MDI3 (three injections daily), and MDI4 (four injections daily). T2DM patients were hospitalized and were randomly assigned to CSII, aspart 30-based MDI3, and glargine based MDI4. Treatments were maintained for 2-3 weeks after the glycaemic target was reached. After completing the baseline assessment, 6-day continuous glucose monitoring (CGM) was performed before and after completion of insulin treatment. Treatment with CSII provided a greater improvement of blood glucose fluctuations than MDI (MDI3 or MDI4) therapy either in newly diagnosed or in long-standing T2DM patients. In long-standing diabetes patients, the MDI4 treatment group had significantly greater improvement of mean amplitude glycemic excursion (MAGE) than the MDI3 treatment group. However, in patients with newly diagnosed diabetes, there were no significant differences in the improvement of MAGE between MDI3 and MDI4 groups. Glargine based MDI4 therapy provided better glucose fluctuations than aspart 30-based MDI3 therapy, especially in long-standing T2DM patients, if CSII therapy was not available.
ATIPS: Automatic Travel Itinerary Planning System for Domestic Areas
Authors: Chang Hsien-Tsung , Chang Yi-Ming , Tsai Meng-Tze
Published: December 2015

Leisure travel has become a topic of great interest to Taiwanese residents in recent years. Most residents expect to be able to relax on a vacation during the holidays; however, the complicated procedure of travel itinerary planning is often discouraging and leads them to abandon the idea of traveling. In this paper, we design an automatic travel itinerary planning system for the domestic area (ATIPS) using an algorithm to automatically plan a domestic travel itinerary based on user intentions that allows users to minimize the process of trip planning. Simply by entering the travel time, the departure point, and the destination location, the system can automatically generate a travel itinerary. According to the results of the experiments, 70% of users were satisfied with the result of our system, and 82% of users were satisfied with the automatic user preference learning mechanism of ATIPS. Our algorithm also provides a framework for substituting modules or weights and offers a new method for travel planning.
TGF‐β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti‐ and Proliver Fibrosis
Authors: Yang Ai-Ting , Hu Dou-Dou , Wang Ping , Cong Min , Liu Tian-Hui , Zhang Dong , Sun Ya-Meng , Zhao Wen-Shan , Jia Ji-Dong , You Hong
Published: December 2015

Transforming growth factor‐beta 1 (TGF‐β1) plays a central role in hepatic progenitor cells‐ (HPCs‐) mediated liver repair and fibrosis. However, different effects of TGF‐β1 on progenitor cells have not been described. In this study, both in vitro (HPCs cocultured with hepatic stellate cells (HSCs) in transwells) and in vivo (CCl4‐injured liver fibrosis rat) systems were used to evaluate the impacts. We found that HPCs pretreated with TGF‐β1 for 12 hours inhibited the activation of HSCs, while sensitization for 48 hours increased the activation of HSCs. Consistent with these in vitro results, the in vivo fibrosis rat model showed the same time‐dependent dual effect of TGF‐β1. Regression of liver fibrosis as well as normalization of serum aminotransferase and albumin levels was detected in the rats transplanted with HPCs pretreated with TGF‐β1 for 12 hours. In contrast, severe liver fibrosis and elevated collagen‐1 levels were detected in the rats transplanted with HPCs pretreated with TGF‐β1 for 48 hours. Furthermore, the TGF‐β1‐pretreated HPCs were shown to deactivate HSCs via enhancing SERPINE1 expression. Inhibition of SERPINE1 reversed the deactivation response in a dose‐dependent manner.
The Role of Adult-Born Neurons in the Constantly Changing Olfactory Bulb Network
Authors: Malvaut Sarah , Saghatelyan Armen
Published: December 2015

The adult mammalian brain is remarkably plastic and constantly undergoes structurofunctional modifications in response to environmental stimuli. In many regions plasticity is manifested by modifications in the efficacy of existing synaptic connections or synapse formation and elimination. In a few regions, however, plasticity is brought by the addition of new neurons that integrate into established neuronal networks. This type of neuronal plasticity is particularly prominent in the olfactory bulb (OB) where thousands of neuronal progenitors are produced on a daily basis in the subventricular zone (SVZ) and migrate along the rostral migratory stream (RMS) towards the OB. In the OB, these neuronal precursors differentiate into local interneurons, mature, and functionally integrate into the bulbar network by establishing output synapses with principal neurons. Despite continuous progress, it is still not well understood how normal functioning of the OB is preserved in the constantly remodelling bulbar network and what role adult-born neurons play in odor behaviour. In this review we will discuss different levels of morphofunctional plasticity effected by adult-born neurons and their functional role in the adult OB and also highlight the possibility that different subpopulations of adult-born cells may fulfill distinct functions in the OB neuronal network and odor behaviour.
Multiple Functions of MSCA‐1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells
Authors: Estève David , Galitzky Jean , Bouloumié Anne , Fonta Caroline , Buchet René , Magne David
Published: December 2015

Our knowledge about mesenchymal stem cells has considerably grown in the last years. Since the proof of concept of the existence of such cells in the 70s by Friedenstein et al., a growing mass of reports were conducted for a better definition of these cells and for the reevaluation from the term “mesenchymal stem cells” to the term “mesenchymal stromal cells (MSCs).” Being more than a semantic shift, concepts behind this new terminology reveal the complexity and the heterogeneity of the cells grouped in MSC family especially as these cells are present in nearly all adult tissues. Recently, mesenchymal stromal cell antigen‐1 (MSCA‐1)/tissue nonspecific alkaline phosphatase (TNAP) was described as a new cell surface marker of MSCs from different tissues. The alkaline phosphatase activity of this protein could be involved in wide range of MSC features described below from cell differentiation to immunomodulatory properties, as well as occurrence of pathologies. The present review aims to decipher and summarize the role of TNAP in progenitor cells from different tissues focusing preferentially on brain, bone marrow, and adipose tissue.
Metaboloepigenetic Regulation of Pluripotent Stem Cells
Authors: Harvey Alexandra J. , Rathjen Joy , Gardner David K.
Published: December 2015

The differentiation of pluripotent stem cells is associated with extensive changes in metabolism, as well as widespread remodeling of the epigenetic landscape. Epigenetic regulation is essential for the modulation of differentiation, being responsible for cell type specific gene expression patterns through the modification of DNA and histones, thereby establishing cell identity. Each cell type has its own idiosyncratic pattern regarding the use of specific metabolic pathways. Rather than simply being perceived as a means of generating ATP and building blocks for cell growth and division, cellular metabolism can directly influence cellular regulation and the epigenome. Consequently, the significance of nutrients and metabolites as regulators of differentiation is central to understanding how cells interact with their immediate environment. This review serves to integrate studies on pluripotent stem cell metabolism, and the regulation of DNA methylation and acetylation and identifies areas in which current knowledge is limited.
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon
Authors: Qi Ran , Zhou Yunfeng , Li Xiaozhen , Guo Hong , Gao Lei , Wu Lijuan , Wang Yufeng , Gao Qiang
Published: December 2015

Aim. To detect the expression of dual oxidase (DUOX) 2 in Barrett esophagus, gastric cancer, and colorectal cancer (CRC).Materials and Methods. The endoscopic biopsies were collected from patients with Barrett esophagus, while the curative resection tissues were obtained from patients with gastric cancer, CRC, or hepatic carcinoma. The DUOX2 protein and mRNA levels were detected with immunohistochemistry (IHC) and real-time quantitative PCR (qPCR). The correlation of DUOX2 expression with clinicopathological parameters of tumors was identified.Results. Low levels of DUOX2 mRNA were detected in Barrett esophagus and the adjacent normal tissues, and there was no difference between these two groups. DUOX2 protein was found in Barrett esophagus and undetectable in the normal epithelium. The DUOX2 mRNA and protein levels in the gastric cancer and CRC were increased compared to the adjacent nonmalignant tissues. The elevated DUOX2 in the gastric cancer was significantly associated with smoking history. In CRC tissues, the DUOX2 protein expression level in stages II–IV was significantly higher than that in stage I. In both hepatic carcinoma and the adjacent nonmalignant tissue, the DUOX2 was virtually undetectable.Conclusion. DUOX2 in Barrett esophagus, gastric cancer, and CRC may be involved in the tumorigenesis of these tissues.
Rotational Angle Measurement of Bridge Support Using Image Processing Techniques
Authors: Park Young-Soo , Agbayani John Arbie , Lee Jong-Han , Lee Jong-Jae
Published: December 2015

Measuring a very small rotational angle accurately and dynamically is indeed a challenging issue, especially in the case of bridge support. Also, existing inclinometers do not have sufficient resolution and accuracy to measure a bridge’s rotational angle. In this study, a new measurement system was developed to provide a practical means for measuring dynamic rotational angle of a bridge support. It features high resolution and accuracy compared with the available systems on the market. By the combinational use of a laser pointer and a vision-based displacement measurement system, the measurement accuracy was significantly increased. The accuracy and applicability were investigated through laboratory tests. From the laboratory tests, it has been found that the developed system can be applicable to bridge support with very small rotational angle. The effectiveness of the developed system was verified through field tests on real bridges. From the full-scale implementation on two PSC girder bridges, it is observed that the proposed system can measure the rotational angle with a high accuracy and reliability.
A Water Hammer Protection Method for Mine Drainage System Based on Velocity Adjustment of Hydraulic Control Valve
Authors: Kou Yanfei , Yang Jieming , Kou Ziming
Published: December 2015

Water hammer analysis is a fundamental work of pipeline systems design process for water distribution networks. The main characteristics for mine drainage system are the limited space and high cost of equipment and pipeline changing. In order to solve the protection problem of valve-closing water hammer for mine drainage system, a water hammer protection method for mine drainage system based on velocity adjustment of HCV (Hydraulic Control Valve) is proposed in this paper. The mathematic model of water hammer fluctuations is established based on the characteristic line method. Then, boundary conditions of water hammer controlling for mine drainage system are determined and its simplex model is established. The optimization adjustment strategy is solved from the mathematic model of multistage valve-closing. Taking a mine drainage system as an example, compared results between simulations and experiments show that the proposed method and the optimized valve-closing strategy are effective.
Microfluidic Sample Preparation Methods for the Analysis of Milk Contaminants
Authors: Adami Andrea , Mortari Alessia , Morganti Elisa , Lorenzelli Leandro
Published: December 2015

In systems for food analysis, one of the major challenges is related to the quantification of specific species into the complex chemical and physical composition of foods, that is, the effect of “matrix”; the sample preparation is often the key to a successful application of biosensors to real measurements but little attention is traditionally paid to such aspects in sensor research. In this critical review, we discuss several microfluidic concepts that can play a significant role in sample preparation, highlighting the importance of sample preparation for efficient detection of food contamination. As a case study, we focus on the challenges related to the detection of aflatoxinM1in milk and we evaluate possible approaches based on inertial microfluidics, electrophoresis, and acoustic separation, compared with traditional laboratory and industrial methods for phase separation as a baseline of thrust and well-established techniques.
Autologous Fat Grafting Reduces Pain in Irradiated Breast: A Review of Our Experience
Authors: Caviggioli Fabio , Maione Luca , Klinger Francesco , Lisa Andrea , Klinger Marco
Published: December 2015

Introduction. Pain syndromes affect women after conservative and radical breast oncological procedures. Radiation therapy influences their development. We report autologous fat grafting therapeutical role in treating chronic pain in irradiated patients. Materials and Methods. From February 2006 to November 2014, we collect a total of 209 patients who meet the definition of “Postmastectomy Pain Syndrome” (PMPS) and had undergone mastectomy with axillary dissection (113 patients) or quadrantectomy (96 patients). Both procedures were followed by radiotherapy. We performed fat grafting following Coleman’s procedure. Mean amount of adipose tissue injected was 52 cc (±8.9 cc) per breast. Seventy‐eight in 209 patients were not treated surgically and were considered as control group. Data were gathered through preoperative and postoperative VAS questionnaires; analgesic drug intake was recorded. Results. The follow‐up was at 12 months (range 11.7–13.5 months). In 120 treated patients we detected pain decrease (mean ± SD point reduction, 3.19 ± 2.86). Forty‐eight in 59 patients stopped their analgesic drug therapy. Controls reported a mean ± SD decrease of pain of 1.14 ± 2.72. Results showed that pain decreased significantly in patients treated (p < 0.005, Wilcoxon rank-sum test). Conclusion. Our 8‐year experience confirms fat grafting effectiveness in decreasing neuropathic pain.
Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study
Authors: Hensel Kai O. , Grimmer Franziska , Roskopf Markus , Jenke Andreas C. , Wirth Stefan , Heusch Andreas
Published: December 2015

Diabetic cardiomyopathy substantially accounts for mortality in diabetes mellitus. The pathophysiological mechanism underlying diabetes-associated nonischemic heart failure is poorly understood and clinical data on myocardial mechanics in early stages of diabetes are lacking. In this study we utilize speckle tracking echocardiography combined with physical stress testing in order to evaluate whether left ventricular (LV) myocardial performance is altered early in the course of uncomplicated type 1 diabetes mellitus (T1DM). 40 consecutive asymptomatic normotensive children and adolescents with T1DM (mean age11.5±3.1years and mean disease duration4.3±3.5years) and 44 age- and gender-matched healthy controls were assessed using conventional and quantitative echocardiography (strain and strain rate) during bicycle ergometer stress testing. Strikingly, T1DM patients had increased LV longitudinal (p=0.019) and circumferential (p=0.016) strain rate both at rest and during exercise (p=0.021). This was more pronounced in T1DM patients with a longer disease duration (p=0.038). T1DM patients with serumHbA1c>9%showed impaired longitudinal (p=0.008) and circumferential strain (p=0.005) and a reduced E/A-ratio (p=0.018). In conclusion, asymptomatic T1DM patients have signs of hyperdynamic LV contractility early in the course of the disease. Moreover, poor glycemic control is associated with early subclinical LV systolic and diastolic impairment.
Interpreting Intervention Induced Neuroplasticity with fMRI: The Case for Multimodal Imaging Strategies
Authors: Reid Lee B. , Boyd Roslyn N. , Cunnington Ross , Rose Stephen E.
Published: December 2015

Direct measurement of recovery from brain injury is an important goal in neurorehabilitation, and requires reliable, objective, and interpretable measures of changes in brain function, referred to generally as “neuroplasticity.” One popular imaging modality for measuring neuroplasticity is task-based functional magnetic resonance imaging (t-fMRI). In the field of neurorehabilitation, however, assessing neuroplasticity using t-fMRI presents a significant challenge. This commentary reviews t-fMRI changes commonly reported in patients with cerebral palsy or acquired brain injuries, with a focus on studies of motor rehabilitation, and discusses complexities surrounding their interpretations. Specifically, we discuss the difficulties in interpreting t-fMRI changes in terms of their underlying causes, that is, differentiating whether they reflect genuine reorganisation, neurological restoration, compensation, use of preexisting redundancies, changes in strategy, or maladaptive processes. Furthermore, we discuss the impact of heterogeneous disease states and essential t-fMRI processing steps on the interpretability of activation patterns. To better understand therapy-induced neuroplastic changes, we suggest that researchers utilising t-fMRI consider concurrently acquiring information from an additional modality, to quantify, for example, haemodynamic differences or microstructural changes. We outline a variety of such supplementary measures for investigating brain reorganisation and discuss situations in which they may prove beneficial to the interpretation of t-fMRI data.