bluuebunny/crossref_metadata_2025 huggingface dataset:
Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events
Authors: Mackay Douglas R. , Howa Amanda C. , Werner Theresa L. , Ullman Katharine S.
Published: July 2017

DNA double-strand breaks are typically repaired through either the high-fidelity process of homologous recombination (HR), in which BRCA1 plays a key role, or the more error-prone process of non-homologous end joining (NHEJ), which relies on 53BP1. The balance between NHEJ and HR depends, in part, on whether 53BP1 predominates in binding to damage sites, where it protects the DNA ends from resection. The nucleoporin Nup153 has been implicated in the DNA damage response, attributed to a role in promoting nuclear import of 53BP1. Here, we define a distinct requirement for Nup153 in 53BP1 intranuclear targeting to damage foci and report that Nup153 likely facilitates the role of another nucleoporin, Nup50, in 53BP1 targeting. The requirement for Nup153 and Nup50 in promoting 53BP1 recruitment to damage foci induced by either etoposide or olaparib is abrogated in cells deficient for BRCA1 or its partner BARD1, but not in cells deficient for BRCA2. Together, our results further highlight the antagonistic relationship between 53BP1 and BRCA1, and place Nup153 and Nup50 in a molecular pathway that regulates 53BP1 function by counteracting BRCA1-mediated events.
Multi-Category Competition and Market Power: A Model of Supermarket Pricing
Authors: Thomassen Øyvind , Smith Howard , Seiler Stephan , Schiraldi Pasquale
Published: July 2017

In many competitive settings, consumers buy multiple product categories, and some prefer to use a single firm, generating complementary cross-category price effects. To study pricing in supermarkets, an organizational form where these effects are internalized, we develop a multi-category, multi-seller demand model and estimate it using UK consumer data. This class of model is used widely in theoretical analysis of retail pricing. We quantify cross-category pricing effects and find that internalizing them substantially reduces market power. We find that consumers inclined to one-stop (rather than multi-stop) shopping have a greater pro-competitive impact because they generate relatively large cross-category effects. (JEL D12, L11, L13, L81)
MINERALOGICAL AND SPECTROSCOPIC STUDY OF NESQUEHONITE SYNTHESIZED BY REACTION OF GASEOUS CO2 WITH MG CHLORIDE SOLUTION
Authors: Skliros V. , Anagnostopoulou A. , Tsakiridis P. , Perraki M.
Published: July 2017

Nesquehonite, a hydrous carbonate with promising uses such as building raw material and treatment of wastewaters, was synthesized under low pressure conditions by reaction of gaseous CO2 with Mg chloride solution and it was studied by means of X-Ray Diffraction, optical and scanning/transmission electron microscopy, and FTIR and Raman spectroscopic methods. Synthesized nesquehonite forms elongated fibers, exhibiting transparent to translucent diaphaneity and vitreous luster. It is characterized by high crystallinity. IR and Raman spectroscopy indicated the presence of OHand HCO3 - in the crystal structure of nesquehonite. The nesquehonite synthesis described herein constitutes a potential permanent storage of CO2 emissions.
AESTHETIC CHARACTERISTICS OF GREEK ORNAMENTAL STONES ASSOCIATED WITH MINERAL, GEOCHEMICAL AND STRUCTURAL PROPERTIES
Authors: Badouna I. , Koutsovitis P. , Laskaridis K. , Patronis M. , Papatrechas Ch.
Published: July 2017

Commercial marble are almost ready-to-use materials with a high economic value for the building-construction industry. The most important ornamental stones in Greece include limestone and marble with notable qualitative features and are considered products of high commercial value. In this research, seventy-three carbonate samples (limestones, dolomites and marbles) from all over Greece have been studied to determine their macroscopic and petrographic features and to investigate their mineral chemistry and geochemistry. Their colors vary from whitish to gray due to their content of calcite and dolomite, black due to bitumens, yellow due to the presence of iron oxides and clay, red due to iron oxides and mixed phases of calcite- siderite, green-brownish due to the presence of iron oxides or muscovite and chlorite, giving schistosity to the rock. Scattered calcite and dolomite veins, as well as the occurrence of other minerals such as barite, epidote and magnetite, contribute to specific features, thus making their appearance unique. The particular characteristics of each stone depend highly upon the type of minerals present, their composition, grain size and extent of aggregation, their geochemistry and structure.
MINERALOGICAL AND GEOCHEMICAL CHARACTERIZATION OF THE OLYMPIAS MINE TAILINGS, NE CHALKIDIKI, GREECE
Authors: Zaimis S. , Vavelidis M. , Alifragkis D. , Melfos V. , Kantiranis N. , Daftsis E. , Gazea E.
Published: July 2017

The Olympias tailings of NE Chalkidiki, Greece represent the mine wastes produced by the beneficiation of the Pb-Zn-Au-Ag ore deposit, which is hosted within the carbonate rocks of the Kerdylia Unit. In the present study X-Ray diffraction (XRD), scanning electron microscopy (SEM), optical microscopy, chemical analyses and pH measurements were conducted to determine the tailings mineralogy and chemical composition. The results indicated that they consist of gangue (quartz, rhodochrosite, calcite, dolomite, feldspars, micas, kaolinite and actinolite) and sulfide minerals (pyrite, arsenopyrite, sphalerite, chalcopyrite and galena), reflecting the source ore and its host rock composition, accompanied by traces of Fe-oxides (magnetite, hematite), Fe oxyhydroxides (goethite) and Mn-oxides, often enriched in Zn and Pb and in some cases Fe, Sb and As. Secondary sulfates (gypsum, jarosite) and surface efflorescent salts (ferrohexahydrite, hexahydrite, halotrichite) have also been recognized. The Olympias tailings are generally unoxidized, generating an alkaline environment. However, variations in composition result in the formation of restricted separate phases, such as thin layers and lenses of oxidized material that generates an acidic environment. In terms of precious metals content, the Olympias tailings are enriched in Au (up to 12 g/t) and Ag (up to 20 g/t).
REDUCTION OF TOXIC ELEMENT MOBILITY IN MINING SOIL BY ZEOLITIC AMENDMENTS
Authors: Giannatou S. , Vasilatos Ch. , Mitsis I. , Koukouzas N. , Itskos G. , Stamatakis G.M.
Published: July 2017

The aim of this study is to examine the effectiveness of natural and synthetic zeolitic materials as potential amendments for the rehabilitation of mine degraded areas. Two types of natural zeolite tuffs, clinoptilolite- and mordenite rich originating from Samos Island, Greece, were used as low cost modifiers. In addition, the synthetic zeolite Na-P1, produced from lignite fly ash of the Meliti Lignite fired Power Station (Florina, Greece), was used. Fly ash was converted into synthetic zeolite via a low temperature alkaline hydrothermal treatment. In order to evaluate the aquatic solubility and potential bioavailability of heavy metals in contaminated soils of the mining area of Lavrion, specific soil amendments were used in leaching experiments. The Na-P1zeolite proved to be the most effective among the tested amendments for in situ de-contamination of mining soils. Comparing the two natural zeolites used, the mordenite-rich tuff exhibited better results than the clinoptilolite-rich, for the reduction of the potential bioavailability of almost all the studied heavy metals. Despite the high trace element content of the specific soils, it was observed that the Glaucium flavum, a plant that grows in the contaminated soils of Lavrion, does not accumulate high concentrations of metals; therefore the high toxic element content of soils does not always influence the physiology of the plants.
INTERACTION OF HEAVY METALS IN THE SOIL-PLANT SYSTEM OF URBAN GARDENS IN ATHENS, GREECE
Authors: Kazantzoglou A. , Argyraki A. , Papageorgiou S. , Fadel D.
Published: July 2017

Preliminary data on the interaction between soil and edible plants with respect to heavy metal concentrations in Athens, Greece are presented. Concentration ranges of Zn, Cu, Ni, Cr, Co, Mn, Fe, Ba, Pb and Cd in soils and vegetables collected from urban allotments in Athens are determined and assessed taking into account the pseudototal (extracted by aqua regia) and mobilizable (0.43 M acetic acid extractable) concentrations of the elements in the rhizosphere soil of the collected plants as well as the total concentrations in plant tissue. Average elemental concentrations in urban allotments are lower than the ones previously reported for Athens urban soil. No detectable concentrations of the non essential heavy metals Pb and Cd were measured in the studied plants while concentrations of micronutrient elements in plants are within normal ranges. The collected data indicate that previous land use is an important factor controlling heavy metal content in soil and that there is a complex mechanism controlling micronutrient uptake by plants.
DISTRIBUTION OF HEAVY METALS CONCENTRATIONS IN SOILS AROUND THE INTERNATIONAL ATHENS AIRPORT (GREECE). AN ASSESSMENT ON PRELIMINARY DATA
Authors: Massas I. , Ioannou D. , Kalivas D. , Gasparatos D.
Published: July 2017

Soils are receptors of atmospheric metal depositions and hence reliable indicators of pollution phenomena, especially for cases that potential site specific pollution sources are detected in terrestrial ecosystems. The purpose of this study was to assess the distribution of Cu, Zn, Fe, Mn, Ni, Cr, Pb, and Ba concentrations in soils nearby the International Athens Airport “El. Venizelos”, in Attica, Greece. Total metal concentrations were determined in 86 topsoil aqua regia extracts and the median values for Cu, Zn, Fe, Mn, Ni, Cr, Pb, and Ba concentrations were 23, 81, 22x103 , 497, 87, 74, 75, and 423 mg kg-1 respectively. Though median values are not considered as high, the 90th percentile concentration values for some metals are high, indicating possible soil enrichment by these metals. A tendency for increased concentrations of Zn and Cr along the north-south axis and of Pb, Cu and Ni at the northern part of the studied area was also observed. As a first approach to discriminate between natural and anthropogenic metal contributions in the soils of the area, the obtained preliminary data were subjected to cluster analysis and to the evaluation of metals Enrichment Factors (EFs). Both EF values and cluster analysis results suggested secondary Pb, Cu and Zn site specific accumulation in the soils of the studied area.
ENVIRONMENTAL GEOCHEMISTRY OF PTOLEMAIS LIGNITES, INTERMEDIATE STERILES, AND COMBUSTION PRODUCTS
Authors: Megalovasilis P. , Godelitsas A. , Papastergios G. , Filippidis A.
Published: July 2017

The environmental geochemistry of lignite, intermediate sterile, fly ash and bottom ash samples from Ptolemais area, has been investigated. The chemical analyses of major elements, combined with SEM-EDS, showed that Si, Ca and Fe, are the most abundant elements and associated with various micro-particles. On average, the most abundant trace elements in the lignite samples are Ba (128 ppm), V (123 ppm), Cr (108 ppm), Sr (107), Ni (43 ppm), in intermediate sterile samples Ba (209 ppm), Sr (209 ppm), Cr (104 ppm), Ni (76 ppm), Zr (67 ppm), Zn (57 ppm), V (53 ppm), in fly ash samples Ba (455 ppm), Sr (336 ppm), Ni (180 ppm), Cr (160 ppm), V (110 ppm), Zr (102 ppm), Zn (74 ppm), Cu (71 ppm), Rb (62 ppm) and in bottom ash samples Ba (250 ppm), Cr (214 ppm), V (174 ppm), Sr (153 ppm), Ni (105 ppm), Zr (56 ppm), Zn (40 ppm)
NATURAL RADIOACTIVITY OF WESTERN ANATOLIAN PLUTONS, TURKEY
Authors: Papadopoulos A. , Altunkaynak S. , Koroneos A. , Unal A. , Kamaci O.
Published: July 2017

The natural radioactivity of the Western Anatolian plutonic bodies (Turkey), as well as the assessment of any potential health hazard due to their usage as decorative building materials is studied. Seventy samples from Western Anatolian plutonic bodies, including various rock-types from quartz-monzodiortie to syenogranite, have been measured for their natural radioactivity using γ-spectrometry. According to the experimental results the natural radioactivity levels were ranged up to 229.62 Bq.kg- 1 for 226Ra, up to 207.32 Bq.kg-1 for 232Th and up to 2541.95 Bq.kg-1 for 40K, with a mean value of 57.67 (±38.13), 80.30 (±42.00) and 1071.92 (±405.24) Bq.kg-1 respectively, which are below the international representative mean values for granite stones. The increment on the external γ-radiation effective dose rate appears a mean value of 0.27 (±0.19) mSv.y-1, scattering below 1 mSv.y-1. In case of the internal α-radiation a mean value of 0.14 (±0.10) mSv.y-1, scattering below 0.5 mSv.y- 1 was estimated. The majority of the samples increase the external and the internal dose less than 30% of the maximum permitted limit of the effective dose rate. Therefore, at least from radiological point of view, the plutonic rocks of Western Anatolia could be safely used as decorative building materials.
PRELIMINARY INVESTIGATION OF THE LAND SUBSIDENCE PHENOMENA OCCURRING AT THE INDUSTRIAL-COMMERSIAL AREA OF ELEONAS, ATHENS, GREECE
Authors: Kaitantzian A. , Loupasakis C.
Published: July 2017

Land subsidence is a common phenomenon occurring in several regions worldwide.The current work focus on the industrial-commersial area of Eleonas, Athens, where vertical displacements were identified by Persistent Scatterer Interferometry (PSI) analysis. The rate of deformation in the study area according to the PSI results, during the period from May 1992 to December 2000, ranged between -1.5 and -10 mm/yr. The evaluation of the geological, geotechnical and hydrogeological conditions of the area combined with the PSI data provided substantial information for the interpretation of the land subsidence phenomenon. Also, the knowledge of the land use distribution and the activities taking place in the area helped the detection of its causal factors.
Thirteenth Century wall paintings in the churches of Rhodes
Authors: Κεφαλά (Konstantia Kefala) Κωνσταντία
Published: July 2017

The study focuses on the monumental painting of the island of Rhodes, Greece, during the 13th century and specifically from the year 1204, when the Byzantine official Leo Gabalas took over the administration of the island, until the arrival of the Knights of Saint John in 1309. The remains of the artistic production are located in six churches in the town and the countryside of Rhodes. The monuments in question are presented in chronological order. After the detailed description and iconographic examination follows the stylistic analysis of the murals along with the proposed dating. In particular, the study deals with the frescoes of Saint Phanourios in the Medieval Town of Rhodes, of the monastery of the Archangel Michael at Thari, of Saint John the Theologian at “Koufas” in Paradeissi, of + Saint Nicetas in Damatria, of Saint George Vardas in Apolakkia and of Saint George in Asklepeio. Two sections in the unit on the church of Saint George Vardas were expanded because of their special interest: one concerns the epithet Panagia Akedioktene which accompanies the representation of the Virgin Glykophilousa and the other deals with the iconography and local cult of Saint Philemon, given his representation in the church. Given that the paintings of the church of Saint George Kounaras at Asklepeio is ascribed to the same hand as that of Saint George Vardas, the painter’s style in both monuments and the particularities of his art are examined in a special chapter. In the final part of the book is developed the overall consideration of the artistic production: the structure and order of the iconographic programmes are assessed, some interesting issues of iconography are discussed, as well as matters concerning the donors of the churches. The stylistic trends are analysed, compared with monuments from other Dodecanese islands and within the artistic currents of the first and second half of the 13th century.
Preprocessed Consortium for Neuropsychiatric Phenomics dataset
Authors: Gorgolewski Krzysztof J. , Durnez Joke , Poldrack Russell A.
Published: July 2017

Here we present preprocessed MRI data of 265 participants from the Consortium for Neuropsychiatric Phenomics (CNP) dataset. The preprocessed dataset includes minimally preprocessed data in the native, MNI and surface spaces accompanied with potential confound regressors, tissue probability masks, brain masks and transformations. In addition the preprocessed dataset includes unthresholded group level and single subject statistical maps from all tasks included in the original dataset. We hope that availability of this dataset will greatly accelerate research.
Consumption of traditional alcoholic beverages in children from a rural village in Northern Peru, 2017
Authors: Ramírez-Ubillus Juan M. , Vilela-Estrada Martín A. , Herrera-Arce Shirley A. , Mejía-Morales Estefany , Mejia Christian R.
Published: July 2017

Introduction: Alcoholic beverages have a proven impact on neuronal development and other areas of the body, primarily the heart, kidneys and liver, which is why their consumption in children is prohibited. However, there are traditional drinks that may have alcohol content. The aim of this study was to characterize the consumption of traditional alcoholic beverages in children of a rural village in Northern Peru. Methods: This study was an analytical cross-sectional study. Mothers were recruited by census sampling and reported the consumption by their children of two traditional drinks with alcoholic content: Chicha de Jora (Ch) and Clarito (Cl), which are derived from the fermentation of maize. The frequency of consumption, accessibility and perception of consumption risk were described. Results: Data were collected about 300 children, 61% (183) of whom consumed Ch. and 31% (92) of whom consumed Ch and Cl. Regarding drink accessibility, the majority of mothers said that these drinks were cheap (Ch: 69.0% and Cl: 60.7%). Additionally, the vast majority of families sometimes consumed or always consumed such beverages (Ch: 81.3% and CI: 65.7%). One in three mothers perceived Ch and Cl as being nutritious and helping their children grow. 25% of mothers perceived that there was no risk to their children from the consumption of the beverages, whereas >60% said that there could be a risk due to the beverages’ alcohol content. Conclusions: Our study found that traditional beverages containing alcohol are consumed frequently by children in a village in Northern Peru. Mothers provide accessibility to the beverages and perceive the risk the drinks have, yet they continue to provide such drinks to their children putting their health in great danger. We advise that future studies concerning the intervention of these attitudes are performed, for a better future and development of children.
Introduction to the Special Issue on Disability Policy in a Time of Change
Authors: Schalock Robert L.
Published: July 2017

The enormous effects of public policy—both for good and for ill—in the lives of people with intellectual disability and related developmental disabilities demand the development of stronger tools for policy analysis, and more effective strategies for policy implementation and evaluation. The purpose of this special issue is to help readers understand the complexities of disability policy and the factors that influence its successful development, implementation, and evaluation; and to encourage readers to expand their thinking and actions regarding the role they play in disability policy in a time of change.
A Model for Analyzing Disability Policy
Authors: Turnbull Rud , Stowe Matthew J.
Published: July 2017

This article describes a 12-step model that can be used for policy analysis. The model encompasses policy development, implementation, and evaluation; takes into account structural foundations of policy; addresses both legal formalism and legal realism; demonstrates contextual sensitivity; and addresses application issues and different conceptualizations of IDD.
An Integrated Approach to Disability Policy Development, Implementation, and Evaluation
Authors: Shogren Karrie A. , Luckasson Ruth , Schalock Robert L.
Published: July 2017

This article provides a framework for an integrated approach to disability policy development, implementation, and evaluation. The article discusses how a framework that combines systems thinking and valued outcomes can be used by coalition partners across ecological systems to implement disability policy, promote the effective use of resources, incorporate specific support strategies that advance identified disability policy goals and lead to systemic changes and enhanced personal outcomes, and focus on activities that advance a unified vision for disability policy and the attainment of personal outcomes. The article concludes with a discussion of the significant challenges and opportunities regarding an integrated approach to disability policy in a time of change.
Intellectual Disability Policy as Developed, Expressed, and Evaluated in AAIDD/The Arc Joint Statements: The Role of Organization Position Statements
Authors: Luckasson Ruth , Ford Marty E. , McMillan Elise D. , Misilo Frederick M. , Nygren Margaret A.
Published: July 2017

The American Association on Intellectual and Developmental Disabilities (AAIDD) and The Arc of the United States (The Arc) have a long history of joined efforts to develop, express, and evaluate disability policies. These efforts have resulted in a series of formal statements on critical issues such as education, healthcare, human rights, and criminal justice. Their joint efforts further important policy goals including providing clear strong communication about important policy values and directions, promulgating key principles of high quality supports and services, affirming best professional practices, and emphasizing personal outcomes. In addition, the joint efforts (a) affirm important aspects of organization identity; (b) enhance the organizations' abilities to assure the input of a wide variety of perspectives; (c) engage members' expanded ranges of experiences and talents; (d) multiply staff and leadership resources; (e) increase communication strength and avenues; and (f) establish processes for timely review and revision of policies as critical disability issues arise or change, and new opportunities for policy integration and advancement occur. This article describes the processes used to develop, express, and evaluate the position statements; summarizes the policy content of several joint statements; and discusses the role of these organization position statements.
DLC/TI THIN FILMS PROPERTIES PREPARED BY HYBRID LASER TECHNOLOGIES
Authors: Mikšovský Jan , Jelínek Miroslav , Písařík Petr , Kocourek Tomáš , Remsa Jan , Jurek Karel
Published: July 2017

Layers of diamond-like carbon are usable in many fields of industry as well as in medicine. Many scientific groups have worked with different types of deposition techniques to prepare DLC layers with improved or unique properties. The DLC properties could be improved by various dopations. In this study, we focused on DLC layers doped by titanium, prepared by hybrid laser depositions. Two techniques were used: Dual pulse laser deposition (DualPLD) and pulse laser deposition in combination with magnetron sputtering (PLD/MS). Preliminary tests for morphology, wettability, adhesion, hardness, corrosion, friction and wearability were examined.
MICROSCOPIC EVALUATION OF THE QUALITY OF DENTAL REPLACEMENT
Authors: Pešlová Františka , Koštialiková Daniela , Veselý Richard , Dubec Andrej , Puchnin Maxim
Published: July 2017

The permanent tooth replacements including metal-ceramic crowns are a convenient solution for the renewing of the original function of the whole set of teeth as well as of the natural appearance. Development and preparation of suitable tooth replacement presents a real challenge for dental engineers as the replacement has to meet all the conditions and requirements of the dental medicine as well as patient’s needs and wishes. The preparation of the metal-ceramic crown is a sophisticated process and the dental engineer has to prepare alwaysa unique replacement on demand. In dental medicine there is a wide spectrum of inorganic and organic materials used formanufacturing of dental replacements. Each of the material has specific properties leading to distinct applications.Besides the material properties, the attention has to be paid to the aesthetic function and biocompatibility of the material to ensure thecomplete restoration of the whole set of teeth.
Perturbation results involving the 1-Laplace operator
Authors: Littig Samuel , Schuricht Friedemann
Published: July 2017

We consider perturbed eigenvalue problems of the 1-Laplace operator and verify the existence of a sequence of solutions. It is shown that the eigenvalues of the perturbed problem converge to the corresponding eigenvalue of the unperturbed problem as the perturbation becomes small. The results rely on nonsmooth critical point theory based on the weak slope.
Freeform surface descriptions. Part II: Application benchmark
Authors: Broemel Anika , Liu Chang , Zhong Yi , Zhang Yueqian , Gross Herbert
Published: July 2017

Optical systems can benefit strongly from freeform surfaces; however, the choice of the right representation is not trivial, and many aspects must be considered. Many possibilities to formulate the surface equations in detail are available, but the experience with these newer representations is rather limited. Therefore, in this work, the focus is to investigate the performance of several classical descriptions as well as one extended freeform surface description in their performance in concrete design optimization tasks. There are different influencing factors characterizing the surface representations, the basic shape, the boundary function, the symmetry, a projection factor, as well as the deformation term describing higher order contributions. We discuss some possibilities and the consequences of describing and using these options with success. These surface representations were chosen to evaluate their impact on all these aspects in the design process. As criteria to distinguish the various options, the convergence over the polynomial orders, as well as the quality of the final solutions, is considered. As a result, recommendations for the right choice of freeform surface representations for practical issues in the optimization of optical systems can be given under restrictions of the benchmark assumptions.
Kommunale Bibliotheken zwischen Kultur und Bildung
Authors: Fries Rudolf
Published: July 2017

Öffentliche Bibliotheken sind immer schon Orte des Lernens gewesen. Um jedoch noch stärker als moderner Lernort wahrgenommen zu werden, müssen sie eine Entwicklung in diese Richtung proaktiv aufnehmen. Dabei kann ihnen helfen, wenn sie den kommunalen Bildungsressorts zugeordnet sind und hier aktiv in die städtische Bildungsentwicklung einbezogen werden. In Trier ist dies gelungen.
A Two-Level Sparse Grid Collocation Method for Semilinear Stochastic Elliptic Equation
Authors: Chen Luoping , Chen Yanping , Liu Xiong
Published: July 2017

In this work, we investigate a novel two-level discretization method for the elliptic equations with random input data. Motivated by the two-grid method for deterministic nonlinear partial differential equations introduced by Xu [36], our two-level discretization method uses a two-grid finite element method in the physical space and a two-scale stochastic collocation method with sparse grid in the random domain. Specifically, we solve a semilinear equations on a coarse mesh

𝒯
H

⁢

(
D
)

{\mathcal{T}_{H}(D)}

with small scale of sparse collocation points

η
⁢

(
L
,
N
)

{\eta(L,N)}

and solve a linearized equations on a fine mesh

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h

⁢

(
D
)

{\mathcal{T}_{h}(D)}

using large scale of sparse collocation points

η
⁢

(
ℓ
,
N
)

{\eta(\ell,N)}

(where

η
⁢

(
L
,
N
)

,

η
⁢

(
ℓ
,
N
)

{\eta(L,N),\eta(\ell,N)}

are the numbers of sparse grid with respect to different levels

L
,
ℓ

{L,\ell}

in N dimensions). Moreover, an error correction on the coarse mesh with large scale of collocation points is used in the method. Theoretical results show that when

h
≈

H
3

,

η
⁢

(
ℓ
,
N
)

≈

(

η
⁢

(
L
,
N
)

)

3

{{h\approx H^{3},\eta(\ell,N)\approx(\eta(L,N))^{3}}}

, the novel two-level discretization method achieves the same convergence accuracy in norm

∥
⋅

∥

ℒ
ρ
2

⁢

(
Γ
)

⊗

ℒ
2

⁢

(
D
)

{\|\cdot\|_{\mathcal{L}_{\rho}^{2}(\Gamma)\otimes\mathcal{L}^{2}(D)}}

(

ℒ
ρ
2

⁢

(
Γ
)

{\mathcal{L}_{\rho}^{2}(\Gamma)}

is the weighted

ℒ
2

{\mathcal{L}^{2}}

space with ρ a probability density function) as that for the original semilinear problem directly by sparse grid stochastic collocation method with

𝒯
h

⁢

(
D
)

{\mathcal{T}_{h}(D)}

and large scale collocation points

η
⁢

(
ℓ
,
N
)

{\eta(\ell,N)}

in random spaces.
Impact of solution conductivity and crack size on the mechanism of environmentally assisted crack growth in steam turbines
Authors: Turnbull Alan , Zhou Shengqi
Published: July 2017

An overview is presented of recent experimental measurements of environmentally assisted crack growth rates for steam turbine blades in simulated condensate solutions. The most notable observation is the complex dependence of stress corrosion and corrosion fatigue crack growth rates on crack size and solution conductivity in the low conductivity solutions associated with turbine condensates. Recent modelling of crack electrochemistry for this system has enabled rationalisation of most of these observations. An intriguing implication of the merging of experimental data and modelling is that the mechanism of cracking could also be dependent on crack size and solution conductivity.
Simulation and Optimization of the Utilization of Triethylene Glycol in a Natural Gas Dehydration Process
Authors: Kamin Zykamilia , Bono Awang , Leong Lek Yan
Published: July 2017

The dehydration unit of a plant that processes natural gas uses triethylene glycol (TEG) as an absorbent to remove water from the gas to prevent blockages in pipes due to the formation of hydrates. Although TEG is recyclable, it is usually lost in the system due to vaporization and carryover, which results in economic issues. Therefore, it is necessary to optimize the dehydration process to achieve the allowable water concentration in the gas, to minimize the use of energy, and to minimize the loss of TEG. Experimental set was designed using Design Expert software by utilising data from Farashband gas processing plant, Iran and subsequently, fed to ASPEN HYSYS to construct and simulate the dehydration process. The chosen affecting parameters to the process were the (1) lean glycol circulation rate, (2) the temperature of the reboiler, and (3) the number of trays in the contactor column. Whereas, the response parameters included the (1) amount of glycol that was lost, (2) the reboiler duty, (3) the concentration of water in the dry gas, and the (4) temperature at which the hydrate formed. Then, these data were optimized using the response surface methodology (RSM). The results indicated that the optimum conditions within the experimental range conducted in this study of process parameters chosen, of the lean glycol circulation rate, the temperature of the reboiler, and the number of trays in the glycol contactor column for the gas dehydration process for the plant were 3944 kg/hr, 180 °C, and three trays, respectively.
256 Shades of gray: uncertainty and diagnostic error in radiology
Authors: Bruno Michael A.
Published: July 2017

Radiologists practice in an environment of extraordinarily high uncertainty, which results partly from the high variability of the physical and technical aspects of imaging, partly from the inherent limitations in the diagnostic power of the various imaging modalities, and partly from the complex visual-perceptual and cognitive processes involved in image interpretation. This paper reviews the high level of uncertainty inherent to the process of radiological imaging and image interpretation vis-à-vis the issue of radiological interpretive error, in order to highlight the considerable degree of overlap that exists between these. The scope of radiological error, its many potential causes and various error-reduction strategies in radiology are also reviewed.
Simulation and the diagnostic process: a pilot study of trauma and rapid response teams
Authors: Juriga Lindsay L. , Murray David J. , Boulet John R. , Fehr James J.
Published: July 2017

Background:

Simulation is frequently used to recreate many of the crises encountered in patient care settings. Teams learn to manage these crises in an environment that maximizes their learning experiences and eliminates the potential for patient harm. By designing simulation scenarios that include conditions associated with diagnostic errors, teams can experience how their decisions can lead to errors. The purpose of this study was to assess how trauma teams (TrT) and pediatric rapid response teams (RRT) managed scenarios that included a diagnostic error.

Methods:

We developed four scenarios that would require TrT and pediatric RRT to manage an error in diagnosis. The two trauma scenarios (spinal cord injury and tracheobronchial tear) were designed to not respond to the heuristic management approach frequently used in trauma settings. The two pediatric scenarios (foreign body aspiration and coarctation of the aorta) had an incorrect diagnosis on admission. Two raters independently scored the scenarios using a rating system based on how teams managed the diagnostic process (search, establish and confirm a new diagnosis and initiate therapy based on the new diagnosis).

Results:

Twenty-one TrT and 17 pediatric rapid response managed 51 scenarios. All of the teams questioned the initial diagnosis. The teams were able to establish and confirm a new diagnosis in 49% of the scenarios (25 of 51). Only 23 (45%) teams changed their management of the patient based on the new diagnosis.

Conclusions:

Simulation can be used to recreate conditions that engage teams in the diagnostic process. In contrast to most instruction about diagnostic error, teams learn through realistic experiences and receive timely feedback about their decision-making skills. Based on the findings in this pilot study, the majority of teams would benefit from an education intervention designed to improve their diagnostic skills.
Undenkbare Möglichkeiten
Authors: Rescher Nicholas
Published: July 2017

It is, of course, impossible to provide examples of inconceivable possibilities. The argument for their existence has to be developed on the basis of general principles and the paper accordingly seeks to show that this can be done in a credible manner. The core of the argument is (1) that our conceptions have to be developed linguistically, (2) that whatever can be managed by language has to proceed recursively, so that in consequence only a denumerable number of conceivable outcomes can be realized, and (3) that there is no reason to think that the range of Reality – let alone the range of Possibility – is of merely denumerable scope.
„Autorität“ als sexuierte Dimension sozialer Beziehungen
Authors: Großmaß Ruth
Published: July 2017

The article refers to social, economic and cultural developments (summed up under the notion of “modernity”) to explain why authority as it was long understood in philosophical and sociological debates is no longer effective. Though the phenomenon of authority has not disappeared from all areas of personal and social life, it is no longer based on a clear structure of male hierarchies, and thus it seems necessary to think about new ways of conceptualizing it. Hannah Arendt’s political theory and Richard Sennett’s socio-anthropological approach are used to describe a core concept of “modern” authority. With the help of ideas from current discourses in some of the “new” professions – e. g. psychotherapy – this concept is further elaborated in an attempt to understand “postmodern” relationships. The last section of the article concentrates on the issue of gender – arguing that the traditionally close linkage between authority and maleness (still a subtext in many discussions) is no longer convincing.
Verdeckte Autorität. Moderne Gefühlsdynamiken
Authors: Landweer Hilge , Newmark Catherine
Published: July 2017

The authors argue that modernity can be defined by a critique of political and social authority. Authority may be described as a form of power; it cannot be understood as an attribute of individuals, but as a form of social interaction, a clear model of which can be found in the relationship between teacher and student. Authority in this sense can be viewed as a way of giving and receiving orientation. It comes in degrees, as part of an ongoing social process of ascription, driven by emotional dynamics such as respect, esteem, admiration, fear and shame. Authority in the modern sense is not only less hierarchical than in the case of classical stereotypes, but also less dependent on traditional male images. The price paid by modern authority, however, is that it is a less visible form of authority, one that has little representation in the popular imagination.
„Was muß das für ein trockenes gramatisch-metaphysisches Geschwätz seyn“
Authors: Salatowsky Sascha
Published: July 2017

This is the first edition of three letters written by Prince August of Saxe-Gotha-Altenburg to the German theologian Johann Gottfried Herder in the years 1784 and 1785. As son of the Duchess Louise Dorothea, Prince August was very familiar with the German and French Enlightenment. He intensely read works by Voltaire, Diderot, Helvetius and similar authors and was able to form his own judgements, even on metaphysical treatises. He described, for example, Spinoza’s philosophy as “dry grammatical-metaphysical claptrap”. His letters to Herder are full of devastating irony, intelligent humour and wit. They give an interesting insight into the intellectual’s debates on literature, philosophy, theology, and arts which are clearly separated from political affairs. The Research Library of Gotha preserves a copy of nearly 200 letters of the prince to Herder.
Wahrheit als existenzieller Wert
Authors: Streubel Thorsten
Published: July 2017

This paper is concerned with a threefold task: (1) I want to show that truth is an existential value. This means that truth is something which is intimately connected with our interest in having a good and self-determined life. (2) My thesis is that such a life is possible only in a truth-oriented society. And a truth-oriented society can’t be imagined without philosophy and sciences playing an important orienting role in it. So a truth-oriented society is in a certain sense a scientific and philosophical society. (3) My aim is therefore to justify (the idea of) a scientific society and especially philosophy as a social institution of ongoing Enlightenment.
Synthesis and micellization of polydimethylsiloxane– carboxy-terminated poly(ethylene oxide) graft copolymer in aqueous and organic media and its application for the synthesis of core-shell magnetite particles
Authors: Pricop Lucia , Durdureanu-Angheluta Anamaria , Spulber Mariana , Stoica Iuliana , Fifere Adrian , Marangoci Narcisa Laura , Dascalu Andrei Ioan , Tigoianu Radu , Harabagiu Valeria , Pinteala Mariana , Simionescu Bogdan C.
Published: July 2017

An amphiphilic graft copolymer having an average of 7-8 carboxyesterterminated poly(ethylene oxide) grafted sequences on each polydimethylsiloxane main chain was obtained by a multistep procedure. Through fluorescence, surface tension and laser diffractometry methods the graft copolymer was proved to undergo micellization in aqueous media. In water, the critical micellization concentrations (CMC) are dependent on pH. Two CMC values were established for pH = 4, i.e. CMC1 = 1.01 g/L and CMC2 = 1.73 g/L corresponding to the transition from single chain to multiple chain micelles and to intermicellar aggregation, respectively. Between CMC1 and CMC2, the dimensions of micelles increased from 18 nm to 46 nm. The graft copolymer was proved to efficiently act as surfactant in the preparation of magnetite particles with a hydrophobic siloxane shell.
Characterization of copolymerization of acrylonitrile with the functionalized comonomers in dimethyl sulfoxide solvent and copolymers suitable for carbon fibers
Authors: Xiang Wang Yan , Yulan Liu , Limin Wang , Yizhen Yang , Chengguo Wang
Published: July 2017

Free-radical solution copolymerization of acrylonitrile (AN) with four comonomers including itaconic acid (IA), acrylamide (AM), methyl acrylate (MA) and ammonium salt of itaconic acid (AIA) were carried out respectively. Every copolymerization process has been named as AN/IA system, AN/AM system, AN/MA system and AN/AIA system respectively, and the attained polymer is regarded as AN/IA, AN/AM, AN/MA and AN/AIA copolymer respectively. Effect of different comonomers on the polymerization kinetics and viscosity of the spinning drop are discussed in detail. The exothermic reaction of polyacrylonitrile (PAN) precursors is determined by differential scanning calorimetry (DSC), and effect of the different comonomers on the stabilization exotherm properties of PAN precursors were also studied. It has been shown that the rate of polymerization decreases distinctly with an increase of IA content, the ammonium modification can obviously increase the hydrophilicity of copolymer. The falling ball viscosity of AN/IA system is lower when compared with the other three systems, but when under the low concentration of monomer, AN/MA system has the highest viscosity. Electron paramagnetic resonance (EPR) indicates that the peak width change for the different copolymer be mainly caused by the spin-spin interaction. The copolymer of AN/AM has the lowest starting-exothermal reaction temperature and AM can alleviate the exothermic reaction and moderate the stabilization exotherm
Study on LLDPE molecular structure characterization by preparative and analytical cross-fractionation
Authors: Jørgensen Jens Kjær , Larsen Åge , Helland Irene
Published: July 2017

Two grades of LLDPE were analysed by a number of methods for fractionation and molecular structure determination (molecular weight, branching density). Methods used were: preparative fractionation according to comonomer content (TREF) and molecular weight (solvent - non solvent), CRYSTAF, SEC, SEC-FTIR and NMR. We explore different ways of combining and processing data to obtain two and three dimensional results. Methods to correct for chain end effects in and construct bivariate distributions from preparative TREF + SEC + NMR data is presented. The methods studied have different drawbacks and advantages. Preparative TREF + SEC + NMR and SEC-FTIR provide most information relative to the labour requirement. In general, the most complete information is obtained from combined interpretation of results from different methods.
Heterogeneization of alpha diimines nickel catalysts for the polymerization of ethylene and methylmethacrylate
Authors: Matos Inês , Fernandes Auguste , Catalão Rita , Botelho do Rego Ana M. , Ascenso José R. , Fonseca Isabel F. , Lemos Francisco , Marques Maria M.
Published: July 2017

In this paper we present two different techniques for the preparation of single site heterogeneous catalyst. The first method consists in the impregnation of a solution of the organometallic compound in MCM41. The second method intends to establish the in situ synthesis of the complex within the solid’s pores by the reaction of the organic ligand with the metal cation previously introduced in the support. The direct deposition of the organometallic complex in the support resulted in an active catalyst which gives polyethylene with the same microstructure as the one obtained with the related homogeneous systems. The heterogeneous catalysts obtained by reaction of the ligand with the metal already present in the support showed a lower catalytic activity.
Role of interfacial interaction on the crystallization behavior and melting characteristics of PP/Nano-CaCO3 composites modified with different compatibilizers
Authors: Wang Yuhai , Shen Hao , Li Gu , Mai Kancheng
Published: July 2017

PP/nano-CaCO3 composites with different interfacial interaction were prepared by addition of compatibilizers with the same polar groups but different backbones. The non-isothermal and isothermal crystallization behavior of PP/nano- CaCO3 composites was investigated using differential scanning calorimetry (DSC). The results indicated that the interfacial interaction between PP and nano-CaCO3 increased the crystallization temperature and crystallization rate of PP due to the heterogeneous nucleation of nano-CaCO3. The interfacial interaction between nano- CaCO3 and compatibilizer further increased the crystallization temperature and crystallization rate of PP and induced the formation of β-crystal of PP due to the synergistic effect of heterogeneous nucleation between nano-CaCO3 and compatibilizer. This synergistic effect of heterogeneous nucleation between nano- CaCO3 and compatibilizer depended on the interfacial interaction between compatibilizer and PP matrix. The increased compatibility between compatibilizer and PP matrix favoured the heterogeneous nucleation between nano-CaCO3 and compatibilizer
Clinical features and genotyping of patients with primary carnitine deficiency identified by newborn screening
Authors: Sun Yun , Wang Yan-yun , Jiang Tao
Published: July 2017

Background:

The objective of the study was to investigate clinical and gene mutation characteristics of primary carnitine deficiency (PCD) patients identified by newborn screening using tandem mass spectrometry (MS/MS).

Methods:

Tandem mass spectrometry (MS/MS) was applied to screen inherited metabolic disease and seven patients with PCD were diagnosed among 62,568 samples. The

Results:

The initial free carnitine (C0) concentrations of the patients were 6.43±1.36 μmol/L, and the recall screening concentrations were 5.59±0.89 μmol/L. The patients were treated with oral carnitine, so the levels after treatment were 20.24±3.88 μmol/L. All patients had two pathogenic mutation alleles.

Conclusions:

The combined application of MS/MS and a next generation sequencing panel could be used for the accurate diagnosis of PCD. The results of genetic diagnosis can guide the assisted reproductive treatment. The prognosis of PCD patients is good after early treatment.
Comparison of healthcare utilization and outcomes by gestational diabetes diagnostic criteria
Authors: Lauring Julianne R. , Kunselman Allen R. , Pauli Jaimey M. , Repke John T. , Ural Serdar H.
Published: July 2017

Objective:

To compare healthcare utilization and outcomes using the Carpenter-Coustan (CC) criteria vs. the National Diabetes Data Group (NDDG) criteria for gestational diabetes mellitus (GDM).

Methods:

This is a retrospective cohort study. Prior to 8/21/2013, patients were classified as “GDM by CC” if they met criteria. After 8/21/2013, patients were classified as “GDM by NDDG” if they met criteria and “Meeting CC non-GDM” if they met CC, but failed to reach NDDG criteria. “Non-GDM” women did not meet any criteria for GDM. Records were reviewed after delivery.

Results:

There was a 41% reduction in GDM diagnosed using NDDG compared to CC (P=0.01). There was no significant difference in triage visits, ultrasounds for growth or hospital admissions. Women classified as “Meeting CC non-GDM” were more likely to have preeclampsia than “GDM by CC” women [OR 11.11 (2.7, 50.0), P=0.0006]. Newborns of mothers “Meeting CC non-GDM” were more likely to be admitted to neonatal intensive care units than “GDM by CC” [OR 6.25 (1.7, 33.3), P=0.006], “GDM by NDDG” [OR 5.56 (1.3, 33.3), P=0.018] and “Non-GDM” newborns [OR 6.47 (2.6, 14.8), P=0.0003].

Conclusion:

Using the NDDG criteria may increase healthcare costs because while it decreases the number of patients being diagnosed with GDM, it may also increase maternal and neonatal complications without changing maternal healthcare utilization.