bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Hand Doll Media on Science Learning Students of Class V Elementary School 6 Srikaton
Authors: Aldian Giri , Frima Aren , Egok Asep Sukenda
Published: December 2022

This study aims to determine the Hand Puppet Media in Science Learning Class V SD Negeri 6 Srikaton and find out how to develop a Hand Puppet Media in Science Learning Class V SD Negeri 6 Srikaton which is valid and practical. This study uses a 4-D development model. The instruments used to measure the quality of the developed hand puppet media include validation sheets and practicality questionnaires. The product of this research is in the form of hand puppets on theme 1 sub theme 1 learning 1 in class V SD Negeri 6 Srikaton. So that this study shows the results of the entire validation component of the expert team including the valid category with an average score of 0,84 for all validators. The practicality of hand puppets received a practical response with an average score of all practicality tests, which was 91,10 %, this indicates that the hand puppet media is already practical.
Academic Procrastination Analysis in Elementary School
Authors: Mawarni Indah , Purnama Ratih
Published: December 2022

The success of education in elementary schools will determine the success of education at the next level. But academic procrastination is one of the threats to the success of education in elementary schools. The objectives of this study were (1) to determine the academic procrastination of students in the class of SD Negeri 1 Nusa Raya, Belitang III sub-district. (2) To determine the factors that cause students' academic procrastination at SD Negeri 1 Nusaraya, Belitang III sub-district. This research uses descriptive qualitative research. The results showed that there was academic procrastination behavior at MTs Mambaul Ulum SD Negeri 1 Nusaraya, Belitang III sub-district, forms of academic procrastination behavior in students including delays and delays in collecting assignments, depending on friends, and poor time management. Factors that cause students to do academic procrastination Internal factors in the form of Lack of motivation to learn, self-discipline, and ideals to be achieved seriously, and also external factors, namely the environment, parenting patterns, and communication technology that affect participants’ students to procrastinate, be late and not submit assignments.
Perspectiva histórica de la importancia de la agremiación odontológica
Authors: Samplonius Angobaldo Anton , Otero-Injoque Jaime
Published: December 2022

La presente editorial brinda una reseña histórica respecto de la asociación gremial como uno de los elementos más relevantes de la práctica odontológica moderna y fundamenta la importancia de los colegios odontológicos contemporáneos en el desarrollo y el avance de la profesión dental. El término gremio se define como un conjunto de personas que tienen el mismo oficio o profesión, y que se asocian para ordenarlo, defenderlo y compartir experiencias. Este vocablo involucra a la totalidad de individuos que trabajan en una misma rama profesional, lo cual contrasta con el concepto de sindicato, que implica una reunión voluntaria de un grupo de estos.
Eficacia de piezoeléctrico versus pieza de mano recta a baja velocidad en la extracción quirúrgica de terceros molares inferiores retenidos
Authors: Morales-Sambachi Bryan , Andrade-Peñafiel Adriana
Published: December 2022

Objetivo. Determinar la eficacia del piezoeléctrico vs la pieza de mano recta a baja velocidad en cirugías de terceros molares inferiores retenidos, en relación con los efectos postquirúrgicos (edema, dolor y trismus) y el tiempo operatorio de osteotomía, en pacientes del Servicio de Cirugía Maxilofacial del Hospital de Especialidades Fuerzas Armadas N°1. Método. Estudio clínico observacional, longitudinal de cohorte prospectivo. Se tomó una muestra de 40 pacientes de ambos sexos con edades entre 18 a 25 años, divididos en dos grupos de 20 pacientes cada uno, en el grupo A se realizaron las osteotomías con piezoeléctrico y en el grupo B con pieza de mano recta rotatoria a baja velocidad. El edema se midió con el método de Amin y Laskin, el dolor con la Escala Visual Análoga (EVA), y la apertura bucal con el instrumento pie de rey, tanto al tercer, quinto y octavo día. Resultados. En el grupo A el edema (11,72 mm), dolor (4,67) y apertura bucal (39,49 mm) fueron menores que en el B edema (12,29 mm), dolor (4,8) y apertura bucal (35,83 mm) y el tiempo de osteotomía fue significativamente mayor con el piezoeléctrico (6,54± 3,05 min) en comparación con el de pieza de mano recta (1,55 ± 0,57 min). Existió diferencia del edema, dolor y trismus en condiciones normales en contraste con el obtenido a los 3, 5, 8 días entre los dos instrumentos. Conclusión. Los efectos postquirúrgicos edema, dolor y trismus de la exodoncia de los terceros molares inferiores retenidos, se presenta en menor intensidad con el piezoeléctrico en comparación a la pieza de mano recta, recomendado el uso del piezoeléctrico.
Efecto de la hipomineralización incisivo molar en la calidad de vida relacionada con la salud bucal de niños y adolescentes: una revisión sistemática
Authors: Romo Pérez Camilo , Lobo Cortés Luis , Morales Rojas María José , San Martín López Alma Luz , Ramírez Vera Karem Guadalupe
Published: December 2022

Introducción: La hipersensibilidad, alteración del aspecto dental y fracturas son problemas comunes en la hipomineralización incisivo molar que generan problemas funcionales y socioemocionales. Objetivo: evaluar el efecto de la HIM en la calidad de vida relacionada con la salud bucal de niños y adolescentes. Materiales y métodos: Se realizó una búsqueda bibliográfica sistemática en bases de datos electrónicas (Pubmed, Epistemonikos, Dentistry & Oral Sciences Source y Biblioteca Virtual en Salud). Se identificaron estudios observacionales en inglés o español realizados entre 2016-2022 que evaluaron la calidad de vida de niños y adolescentes con hipomineralización incisivo molar. Resultados: De 96 estudios identificados, trece fueron incluidos en la síntesis. El criterio diagnóstico para hipomineralización incisivo molar más frecuente fue European Academy of Paediatric Dentistry index y nueve estudios informaron la gravedad de la enfermedad. La escala para medir calidad de vida más usada fue Child Perception Questionnaire (CPQ). Según la percepción de los niños las dimensiones más afectadas fueron “Síntomas Orales” y “Bienestar Emocional”, según los padres fueron “Síntomas Orales” y “Limitación Funcional”. Las niñas con hipomineralización incisivo molar tuvieron peor calidad de vida relacionada con la salud bucal. Conclusiones: El efecto negativo de la hipomineralización incisivo molar en la calidad de vida relacionada con la salud bucal infantil parece variar entre la percepción de los padres y de los niños.
Cándida albicans: factor agravante en pacientes COVID-19
Authors: San Martín Andrade Daniela , Cárdenas Amendaño Cristopher Andrés , Solórzano Cuenca Allison Brigitte , Ulloa Pacheco Johanna Maribel , Medina-Sotomayor Priscilla
Published: December 2022

Para relacionar la presencia de Cándida Albicans como un factor agravante en pacientes con COVID-19, se realizó una revisión bibliográfica en las bases de datos Redalyc, Scielo, PubMed, Research gate, Science direct, Google Académico. Los criterios de inclusión utilizados fueron: artículos en inglés y español además de artículos publicados desde al año 2020 hasta la fecha. Se analizaron 65 artículos científicos que cumplieron con los criterios de búsqueda y se pudo determinar que la cándidiasis oral afecta de manera negativa a pacientes con infección COVID-19, aumentando el riesgo de ingreso a UCI con uso de ventiladores artificiales.
Personas sordas y lengua de señas: un enigma en Odontología
Authors: Muñoz Quispe Mirian Elizabeth , Mendoza Condor Michaell Jeremy , Cahuana Vilchez Jorge Enrique , Mattos-Vela Manuel Antonio
Published: December 2022

La lengua de señas es el principal medio de comunicación de las personas sordas; consiste en la combinación de movimientos manuales, corporales y faciales con significados específicos. Entre las principales barreras a las que se enfrenta esta comunidad resaltan la falta de comunicación, escasez de servicios de salud, sumado a la inexperiencia y desconocimiento de la lengua de señas por parte del profesional de la salud. El presente artículo tiene como objetivo dar a conocer la importancia y necesidad de la lengua de señas en la atención clínica odontológica y en la formación profesional, así como de estrategias, herramientas y recomendaciones para una mejor atención de las personas sordas. Se incluyeron bases de datos como Scielo, Google Scholar, Pubmed y ScienceDirect durante los años 2007 y 2021. Se concluyó que las principales barreras durante la comunicación es el poco dominio de lengua de señas en los odontólogos, el poco acceso a intérpretes y  dificultades en la obtención de citas; repercutiendo en la susceptibilidad a desarrollar enfermedades bucodentales. La inclusión de cursos de lengua de señas dentro de la currícula universitaria aportan beneficios académicos y en la ética profesional; aún así, es necesario un seguimiento que corrobore el cumplimiento de los parámetros solicitados. Dentro de las principales herramientas y estrategias, el uso de videos educativos, el acompañamiento de intérpretes y -en vista del desarrollo tecnológico- el uso de aplicativos móviles, pueden facilitar la comunicación. Asimismo, se plantea un conjunto de recomendaciones para el abordaje de pacientes sordos adultos y niños.
Estrategias para la utilización de la tomografía de haz cónico en dientes con sospecha de fractura radicular. Reporte de serie casos
Authors: Landa de Bellera Rossana
Published: December 2022

Las fracturas radiculares constituyen, después de la caries y la enfermedad periodontal, la tercera causa de pérdida de piezas dentarias, y son muy comunes en dientes posteriores y endodónticamente tratados. La sintomatología que producen es ambigua y su diagnóstico depende del engranaje de múltiples factores clínicos e imagenológicos. Entre los estudios diagnósticos disponibles para establecer el origen de los síntomas está la tomografía computarizada de haz cónico (TCHC). El objetivo del presente reporte de casos es la descripción de las estrategias empleadas en la adquisición e interpretación de la TCHC en tres pacientes con la sospecha de fracturas radiculares. El uso de un campo de visión reducido, con un voxel de 0,150 mm o menor, acompañado por la exploración dinámica del volumen, posibilitaron la detección de defectos óseos como signo indirecto para la localización de las líneas de fractura radicular.
Implante de 5,5 mm. Una solución para atrofias severas sin renunciar a la predictibilidad
Authors: Anitua Eduardo
Published: December 2022

La rehabilitación de zonas de maxilar y mandíbula con extrema reabsorción es un hecho de mayor presencia en nuestra consulta dental. Contar con técnicas quirúrgicas como los implantes cortos y extracortos nos facilitan la resolución de estos casos clínicos. En el presente reporte de caso clínico, desarrollamos un caso rehabilitado mediante un implante de 5,5 mm de longitud y aportamos un estudio biomecánico del comportamiento de implantes de estas características.
Multilevel Lumbar Fusion and Sacral Fusion Affect Joint Space Narrowing of the Hip: A Retrospective Study
Authors: Ukai Taku , Katoh Hiroyuki , Yokoyama Katsuya , Omura Haruka , Watanabe Masahiko
Published: December 2022

Background: This study aimed to elucidate the effect of lumbosacral fusion on joint space narrowing of the hip.
Methods: We retrospectively studied 511 hips of 261 patients who had undergone lumbar fusion. Whole-spine X-ray was performed for all the patients before surgery and at the final follow-up. Center edge angle, joint space of the hip, sagittal vertical axis, thoracic kyphosis, lumbar lordosis, pelvic incidence, pelvic tilt, and sacral slope were measured. The number of lumbar fusion levels, inclusion of sacral fusion, follow-up duration, and wear of the hip joint (mm/year) were also recorded. Multi regression analysis was performed to identify the risk factors for joint space narrowing.
Results: Female sex (P=0.04), number of fixed lumbar levels (P=0.002), sacral fusions (P=0.039), and follow-up period (P<0.001) were independent risk factors for joint space narrowing of the hip. The patients who underwent four or more levels of lumbar fusion experienced more rapid wearing of the hip joint space than that experienced by patients with less than three levels of lumbar fusion (P=0.044).
Conclusion: Surgeons should pay attention to joint space narrowing of the hip after performing multiple lumbar fusions or sacral fusion in women.
Macroeconomic Factors and the Prospects of Economic Prosperity in a Developing Economy: Evidence from Dynamic ARDL Simulations and KRLS Techniques
Authors: Aladejare Samson Adeniyi
Published: December 2022

This study simulated the counterfactual shock effects of inflation and exchange rates on economic prosperity (measured by GDP per capita) when considering deficit financing, foreign investment, and financial development for Nigeria from 1970 to 2020. Empirical inferences were derived by applying the novel dynamic ARDL and the Kernel regularised least squares models. Applying both techniques enabled the response of economic prosperity to future counterfactual shocks to the inflation and exchange rate variables. It was observed that inflationary shocks might have long-term beneficial effects on economic prosperity; however, shocks to the exchange rate will erode these benefits. Findings also showed that inflation rate and deficit financing adversely impacted short and long-term economic wealth. Contemporaneously, the exchange rate and financial development only benefited economic prosperity in the long term, while foreign investment was ineffectual. The study also proposed several policy measures.
Factors associated with the severity of premenstrual symptoms in women with central obesity: a cross sectional study
Authors: Sharifan Payam , Esfahani Ali Jafarzadeh , Zamiri Amir , Toosi Mansoureh Sadat Ekhteraee , Sedghdoost Fatemeh , Taghizadeh Niloufar , Mohammadi-Bajgiran Maryam , Ghazizadeh Hamideh , Sahranavard Toktam , Ferns Gordon , Ghayour-Mobarhan Majid
Published: December 2022

Introduction: Premenstrual syndrome (PMS) is a common condition that affects social and psychological well-being of women. The risk of PMS is higher among obese women. The aim of this study was to identify the factors that influence the severity of PMS in women with central obesity.
Materials and methods: This cross-sectional study was performed on 30 to 50-year-old women who were 30 to 50-year-old with abdominal obesity (waist circumference > 80cm). The following data were collected: demographic data, anthropometric measurements, premenstrual symptoms screening tools (PSST), semi-quantitative food frequency questionnaire (FFQ), 42-item depression, anxiety, and stress questionnaire (DASS-42), as well as serum vitamin D, and renal function tests.
Results: A total of 139 women (mean age of 41.40 ± 7.39 years old) participated in the study. The prevalence of mild, moderate and severe premenstrual symptoms was 38.7% (55/142), 31.7% (45/142) and 27.5% (39/142), respectively. There was no significant difference between the groups in terms of anthropometric measurements and energy-adjusted nutrient intakes (p>0.05). There was a significant relationship between moderate PMS and energy-adjusted saturated fatty acid (SFA) (p=.018, OR=.010 and 95% CI for OR: <.001 and .452), and energy-adjusted riboflavin (p=.042, OR=.005, 95% CI for OR: <.001 and .821), and between severe PMS and age (p=.034, OR=.906, 95% CI for OR: .826 and .993), and energy-adjusted monounsaturated fatty acid (MUFA) intake (p=.041, OR=23.789, 95% CI for OR: 1.138 and 497.294).
Conclusions: High intakes of MUFA and younger age were associated with a greater severity of PMS, while riboflavin intake was associated with reduced PMS severity.
Gains and Losses: A Phenomenographic Study on Adolescents’ Understanding of Isolation due to COVID-19
Authors: Rosali Leann Jester , Erojo Kreen , Dicto Princess Joy
Published: December 2022

The global health emergency posed by the COVID-19 outbreak has affected millions of people. In the Philippines, among the establishments closed are schools which resulted in children and adolescents staying at home for years under quarantine. Many studies were conducted focusing on the impact of isolation on people's physical and emotional well-being, most notably the children and adolescents who are considered vulnerable individuals. However, limited studies investigated how these young people understand their experiences while in quarantine. Hence, this phenomenographic study aims to provide insights into Filipino adolescents' realities by exploring the many different ways they view isolation. Seventeen adolescents in quarantine were interviewed, and qualitative analysis revealed an outcome space where isolation is seen in the light of gains and losses as described in three emerging ways of understanding. The descriptions reveal understandings that isolation is (1) a restraint, (2) a necessity, and (3) an opportunity that has an impact on the physical, emotional, and social dimensions of adolescents' lives. Implications and recommendations presented may serve as a basis for designing programs and interventions to help adolescents deal with possible negative feelings in isolation and post-quarantine.
Delphi panel to obtain clinical consensus regarding the importance of rapid reduction in depressive symptoms in patients with major depressive disorder with acute suicidal ideation or behavior (MDSI)
Authors: Borentain Stephane , McCormick Carter , Joshi Kruti , O’Hara Marguerite , Zhang Qiaoyi , Haughey Siobhan Mulhern , Richards Sarah , Anjo Joana , Zante David , Kewley Rachel , Riley Danielle , Nagda Nirav , Perry Richard
Published: December 2022

Background: Though oral antidepressants can be effective at reducing depressive symptoms, they can take 4–6 weeks to reach full effect. Limitations relating to slow onset of action and resistance to current treatments for patients with major depressive disorder (MDD), particularly for MDD in a psychiatric emergency such as major depressive disorder with acute suicidal ideation or behavior (MDSI), is an issue across all countries and healthcare settings. Due to the current unmet needs and slow onset of action from oral antidepressants, patients with MDSI need interventions that provide a rapid relief of depressive symptoms. This study aimed to identify unmet needs in the treatment for MDSI, specifically exploring the potential clinical benefits of a rapid reduction of depressive symptoms, associated with treatment with rapid acting antidepressant such as esketamine nasal spray.
Methods: A Delphi panel consisting of independent psychiatrists experienced in treating patients with MDSI (n=12) from the United States, Canada, United Kingdom, and European Union, was conducted between December 2020–June 2021. Psychiatrists were recruited and screened by an independent party to ensure that they had the required experience. Psychiatrists completed two rounds of anonymized questionnaires, and a virtual consensus meeting to collect their perceptive on current treatments for MDSI.
Results: This research confirmed current unmet needs in the treatment of patients with MDSI. Hopelessness, functional impairment, worsening of symptoms, recurrent hospitalization and higher risk of suicide attempt were considered key consequences of the slow onset of action of oral antidepressants. Psychiatrists anticipated that treatment with rapid-acting antidepressants would provide benefits such as shorter hospital stays, improved patient engagement/compliance, and improved patient outcomes. For long-term benefits, psychiatrists agreed that improved daily functioning and increased trust/confidence in treatment options were key benefits of rapid-acting antidepressants.
Conclusions: These findings suggest that the use of rapid-acting antidepressants such as esketamine nasal spray, in a psychiatric emergency, may help alleviate some of the current unmet needs experienced by patients with MDSI. This Delphi panel of psychiatrists highlighted that treatment with rapid-acting antidepressants can provide clinically meaningful benefits in the and long-term, as well as the immediate- and short-term, for patients with MDSI.
Climbing perch Anabas testudineus avoid expanded polystyrene pellets ingestion
Authors: Ganzha Ekaterina , Pavlov Efim , Duc Dien Tran
Published: December 2022

The climbing perch Anabas testudineus is widespread in the inland waters of Vietnam and according to its ecology could have contact with a floating plastic waste. The fragments of expanded polystyrene (EPS) detected into the fresh waters of Vietnam in Khanh Hoa, Lam Dong, Phu Yen provinces. Our study was focused on estimation of probability of ingestion of EPS pellets (size 2.5–3.5 mm) by adult climbing perch. In the experiments three types of treatment pellets were proposed to fish: 24 feed pellets (Fp), 24 expanded polystyrene pellets (Pp), 12 feed & 12 expanded polystyrene pellets (FPp). Fish grasping time of first pellet was independent in all treatment types. The time grasping of 12th pellet was insignificant in Fp (63 s) and Pp (75 s). Climbing perch was grasping and ingesting of 24th Fp significantly (p = 0.02) earlier (143 s), than grasping of 24th Pp (817 s). Fish with FPp treatment was grasping feed along with EPS pellets, but grasping of 12th Fp was significantly (p = 0.02) earlier (49 s), then 12th Pp (193 s). By the end of tests fish ingested all feed pellets. We discovered that climbing perch grasped Pp and kept them in oral cavity, but always rejected them in 100% cases. This result evidenced that climbing perch has effective defense mechanism avoiding ingestion of expanded polystyrene pellets with size 2.5–3.5 mm, which realized by taste system and tactile reception of fish.
Overexpression of a WRKY transcription factor McWRKY57-like from Mentha canadensis L. enhances drought tolerance in transgenic Arabidopsis
Authors: Bai Yang , Zhang Ting , Zheng Xiaowei , Li Bingxuan , Qi Xiwu , Yu Xu , Li Li , Liang Chengyuan
Published: December 2022

Background: Drought has become a major environmental problem affecting crop production. Members of the WRKY family play important roles in plant development and stress responses. However, their roles in mint have been barely explored.
Results: In this study, we isolated a drought-inducible gene McWRKY57-likefrom mint and investigated its function. The gene encodes a group IIc WRKY transcription factor, McWRKY57-like, which is a nuclear protein with a highly conserved WRKY domain and a C2H2 zinc-finger structure, and has transcription factor activity. Its expression levels were examined in different tissues of mint and under the treatment of mannitol, NaCl, abscisic acid, and methyl jasmonate. We found that McWRKY57-likeoverexpression in Arabidopsis significantly increased drought tolerance. Further studies showed that under drought stress, McWRKY57-like-overexpressing plants had higher chlorophyll, soluble sugar, soluble protein, and proline contents but lower water loss rate and malondialdehyde content than wild-type plants. Moreover, the activities of antioxidant enzymes catalase, superoxide dismutase, and peroxidase were enhanced in McWRKY57-like transgenic plants. Furthermore, qRT-PCR analysis revealed that the drought-related genes AtRD29A, AtRD29B, AtRD20, AtRAB18, AtCOR15A, AtCOR15B, AtKIN2, and AtDREB1A were upregulated in McWRKY57-liketransgenic plants than in wild-type Arabidopsis under drought conditions.
Conclusion: These data demonstrated that McWRKY57-like conferred drought tolerance in transgenic Arabidopsis by regulating plant growth, osmolyte accumulation and antioxidant enzyme activities, and the expression of stress-related genes. The study indicates that McWRKY57-like plays a positive role in drought response in plants.
Monocular 3D Human Pose-Estimation Networks for Coherent Humanoid-Model Driving
Authors: Yang Wei-Jong , Chan Din-Yuen , Liou Jhih-Siang
Published: December 2022

In this paper, we propose a vivid 3D pose driving (3PD) system containing 2D skeleton pose estimation (2D SPE) network, 3D association pose estimation (3D APE) network and 3D angle-matching (3D-AM) engine. The 2D SPE network consecutively predicts the joint coordinates of human 2D pose per frame for a video string. Then, the 3D APE network associates the successive 2D poses to predict the 3D skeletons of dynamic poses, which can be a causal or non-causal temporal convolutional network. The experimental results demonstrate that the integration of the 2D SPE network and the non-causal 3D APE network can generate accurate dynamic 3D skeletons. Then, the 3D-AM engine can apply those dynamic 3D skeletons to stably drive an on-line 3D avatar. By our 3PD system, the driven avatar can coherently follow user’s dynamic motions with natural agile activities for VR applications. The experimental results can demonstrate that the integration of 2D SPE and 3D APE networks can in usual attain the accurate 3D human-pose estimation without anyone auxiliary training appropriated to occluded joints. Besides, relative to the compared state-of-art networks, our integrated convolutional neural network (CNN) can have structural regularity and computational lightweight.
Neuroprotective effects of ivermectin against transient cerebral ischemia-reperfusion in rats
Authors: Seyyedabadi Behdad , Babataheri Shabnam , Laher Ismail , Soraya Hamid
Published: December 2022

Stroke is a leading cause of disability and death worldwide. Ivermectin is a broad-spectrum anti-parasitic agent with potential anti-bacterial, anti-viral, and anti-cancer effects. However, the effects of ivermectin on the brain are poorly described. This study examined the effects of ivermectin on cerebral ischemia-reperfusion (IR) in rats. A rat model of transient global IR was induced by bilateral carotid artery occlusion for 20 min. Rats received ivermectin (2 mg/kg/day, ip) one hour after inducing cerebral IR for three consecutive days at 24-h intervals. Next, we examined the effects of ivermectin on brain infarction, histopathology, malondialdehyde levels, myeloperoxidase activity, spatial learning and memory, and phospho-AMPK protein levels. The results showed that ivermectin reduced brain infarct size (P < 0.001) and histopathological changes such as cerebral leukocyte accumulation and edema (P < 0.05) compared to untreated rats with IR. Treatment with ivermectin also decreased myeloperoxidase activity (P < 0.01) and malondialdehyde levels (P < 0.05) while increasing AMPK activity (P < 0.001), memory, and learning compared to the untreated IR group. Overall, we show for the first time that ivermectin conferred neuroprotective effects in a rat model of cerebral IR. Our results indicate that ivermectin reduced brain infarct size, lipid peroxidation, and myeloperoxidase activity and improved memory and learning in rats with cerebral IR. These effects likely occurred via AMPK-dependent mechanisms.
Effect of a Remote Peer-administered Behavioral Activation and Peer-support intervention for Antenatal Depression on Gestational Age at Delivery: a single-blind, randomized control trial
Authors: Chaput Kathleen , Freeman Makayla , McMorris Carly , Metcalfe Amy , Cameron Emily E , Jung James , Tough Suzanne , Hicks Laurel M. , Dimidjian Sona , Tomfohr-Madsen Lianne
Published: December 2022

Background: Antenatal depression (AD) is the most common complication of pregnancy in developed countries and increases risk of preterm birth (PTB). Many pregnant individuals with AD do not obtain treatment due in part to risks associated with antidepressant medications, the expense and wait times for psychological services, and perceived stigma. Accessible and timely treatment of antenatal depression is crucial to minimize foetal impacts and associated long-term child health outcomes. Previous studies show that behavioural activation and peer-support are promising avenues of treatment for perinatal depression. Additionally, remote and paraprofessional counselling interventions show promise as more accessible, sustainable, and cost-effective treatment avenues than traditional psychological services. The primary aim of this trial is to test the effectiveness of a remote, behavioural activation and peer support intervention, administered by trained peer para-professionals, for increasing gestational age at delivery among those with antenatal depression. The secondary aims are to evaluate the effectiveness for treating AD prior to delivery, with persistence into the postpartum; improving anxiety symptoms; and improving parenting self-efficacy compared to controls.
Methods: A two-arm, single-blinded, parallel groups randomized controlled trial (RCT) with repeated measures will be conducted. Participants scoring >10 on the Edinburgh Postnatal Depression Scale will be recruited from the larger P3 cohort and invited to enroll. Assessments will be conducted prior to 27 weeks’ gestation at trial intake (T1), post-intervention, prior to delivery (T2), 5-6 months postpartum (T3), and 11-12 months postpartum (T4) and will include self-report questionnaires and linked medical records.
Discussion: Our remote, peer paraprofessional-delivered behavioural activation plus peer support intervention has the potential to successfully reduce symptoms of AD, which may in turn decrease the risk of PTB and subsequent health impacts. The current trial builds on previous findings and uses a patient-oriented approach to address priorities for patient care and to provide a cost-effective, accessible, and evidence-based treatment to pregnant individuals with AD.
Trial registration: ISRCTN51098220
Human Glioma Endothelial Cells With Stem cell properties
Authors: Sharma Aman , Muzumdar Dattatraya , Shiras Anjali
Published: December 2022

Glioblastoma (GBM) tumor relapse is attributed to presence of therapy defying Glioma stem cells (GSCs). GSCs have been shown to trans-differentiate into endothelial-like cells. However, the influence of tumor micro-environment on endothelial cells is not clearly understood. Here, we investigated whether tumor micro-environment conditioning can alter endothelial cell phenotype and endow them with stem cell-like properties. For this, we establishing a battery of primary human glioma endothelial cell cultures (hGECs) and characterized them for purity in multiple in vitro, in vivo assays. Our data shows that hGECs harbored stemness and multi-lineage differentiation potential as assessed in serum free growth assay, sphere forming assay, limiting dilution assay, and in a serum-induced differentiation assay where Nestin and CD31 co-expressing hGECs could spontaneously differentiation into GFAP positive cells. Moreover, immunohistochemistry analysis of human GBM tumors showed that tumor vessel regions expressed two key stem cell specific markers Nestin and Mushashi. Together, our data shows that tumor-specific endothelial cells are enriched with stem cell properties in GBM.
The level of Knowledge, Attitudes, and Practices concerning Covid-19 Vaccination and their Determinants in Chittagong District (Bangladesh)
Authors: Akter Sahin , Bajinka Ousman , faria Faiza shareen , Ashrafuzzaman Mohammad , Liu Aizhong
Published: December 2022

Background: Bangladesh has not previously experienced epidemics such as SARS or MERS, and it is clear that its public healthcare systems are not readily prepared for COVID-19 vaccine uptake.
Objective: The aim of this research was to evaluate the level of knowledge, attitudes, and practices concerning COVID-19 vaccination and their determinants in Chittagong District, Bangladesh.
Methods: This descriptive cross-sectional study was conducted in Chittagong, Bangladesh, from October 2021 to April 2022. A study of 2,882 men and women who had been vaccinated with the COVID-19 vaccine and those who had not been vaccinated was conducted in Chittagong, Bangladesh. A purposeful sampling method was used in this study. The data was collected using a standardized pretested questionnaire.
Results: A total of 850 men and women’s information was obtained, of which Group A = 205 (24.12%) for men and women who had been vaccinated, and Group B = 645 (75.88%) for men and women who had not been vaccinated. There were group/independent variables that entered the equation for subgroup analysis. Sensitivity analysis showed that the majority of the men and women that had been vaccinated had a good level of knowledge, attitudes, and practices regarding COVID-19 vaccination with (OR=0.166, 95% CI: 0. 113~0.245) and (OR=0.191, 95% CI: 0. 113~0.245), respectively. In addition, most of the men and women that were unvaccinated had poor/bad level of knowledge, attitudes, and practices regarding COVID-19 vaccination with (OR=0.228, 95% CI: 0.154~0.336) and (OR=0.239, 95% CI: 0.154~0.336), respectively. Most of the participants were aged between 40-49 years. The majority of the participants were Muslims, had secondary school level of education, and were employed.
Conclusion: The results suggest that the epidemic has significantly increased the level of knowledge, attitudes, and practices concerning COVID-19 vaccination. In addition, the factors affecting the level of knowledge, attitudes, and practices concerning COVID-19 vaccination are different. This means that relevant pro-vaccination promotion strategies are needed to ensure the safety of the people during the epidemic. Under the normalization of the epidemic situation, the local area should optimize public health education, allocate medical resources rationally, and avoid ignoring the routine COVID-19 vaccination for effective and efficient prevention and control of the rapid spread of the COVID-19 epidemic.
Long-Term Outcomes of TEVAR for Thoracic Aortic Diseases: A Retrospective Single-Center Study
Authors: Deniz Gökay , Ozcınar Evren , Kasimzade Ferit , Yazicioglu Levent , Eryilmaz Sadik
Published: December 2022

Background: Long-term outcomes of TEVAR for different aortic pathologies are still debated for years. The procedural success and outcomes differ by comorbidities and thoracic aortic pathologies. Therefore, we present our ten-year experience, encountered rare complications, and long-term results.
Methods: Between 2006 to 2018, 97 patients underwent endovascular treatment for several indications. The primary endpoints are to explore the leading mortality causes, complications, and reinterventions, evaluate the effects of comorbidities on survival, and compare several indications with survival curves. The second is to investigate rare complications and graft durability in long-term follow-ups.
Results: The most indication was thoracic aortic aneurysm (n=52). Ten patients had aortic arch variations and anomalies, and the bovine arch was observed in 8 patients. Endoleaks were the main encountered complication, and 10 of 15 endoleaks were type 1 endoleak. Total reinvention was 18, and the most intervention was reTEVAR (n=5). Overall mortality was 20, and TEVAR-related death mortality was 12. Multivariant Cox regression revealed chronic renal diseases (OR=11.73; 95% CI:2.04-67.2; p=0.006), previous cardiac operation (OR:14.26; 95% CI: 1.59-127.36; p=0.01), chronic obstructive pulmonary diseases (OR:7.82; 95% CI: 1.43-42.78; p=0.001) to be an independent risk factor for 10-year-survival. There was no significant difference in the Kaplan-Maier survival curves of different aortic pathologies.
Conclusion: In long-term follow-ups, comorbid factors could independently be risk factors for mortality; however, there is no significant difference in endoleaks occurrence. TEVAR is a suitable solution for severe aortic pathologies with similar outcomes. Graft thrombosis in years should be a question on graft durability.
Opioid-free anesthesia with lidocaine for better postoperative recovery in hysteroscopy
Authors: Cha Ning-hui , Hu Yang , Zhu Guo-hong , Long Xiang , Jiang Jing-jing , Gong Yuan
Published: December 2022

BACKGROUND: Anesthesia with opioids negatively affects patients’ quality of recovery, and opioid-free anesthesia attempts to avoid these effects. This study aimed to evaluate the effect of opioid-free anesthesia on the quality of recovery, using lidocaine on patients undergoing hysteroscopy.
METHODS: A parallel-group, randomized, double-blind, controlled trial was conducted in Yichang Central Peoples’ Hospital, Hubei Province, China, from January to April, 2022. We included 90 female patients (age: 18–65 years, American Society of Anesthesiologists Physical Status Class I–II) scheduled for elective hysteroscopy, 45 of whom received lidocaine (Group L), and 45 received sufentanil (Group S). Patients were randomly allocated to receive either lidocaine or sufentanil perioperatively. The primary outcome was the quality of postoperative recovery, which was assessed using the QoR-40 questionnaire.
RESULTS: The two groups were similar in age, American Society of Anesthesiology physical status, height, weight, body mass index, and surgical duration. The QoR scores were significantly higher in Group L than in Group S. The incidence of postoperative nausea and vomiting, as well as the time to extubation were significantly lower in Group L than in Group S.
CONCLUSION: Opioid-free anesthesia with lidocaine achieves a better quality of recovery, faster recovery, and a shorter time to extubation than general anesthesia with sufentanil.
TRIAL REGISTRATION: The trial was registered on January 15, 2022 in the Chinese Clinical Trial Registry (http://www.chictr.org.cn/showprojen.aspx?proj=149386), registration number ChiCTR2200055623.(15/01/2022)
Arithmetic skills are associated with grey matter volume in the left inferior frontal gyrus:
A brain-wide association study with 536 children and adolescents
Authors: Viesel-Nordmeyer Nurit , Prado Jerome
Published: December 2022

Although mental arithmetic is a foundation for mathematical development, it is also the source of large individual differences across development. Although a number of brain-wide association studies have attempted to identify the neural correlates of these individual differences, these studies were largely underpowered and have yielded inconsistent results. In the current voxel-based morphometry study, we merged six structural imaging datasets of children and adolescents (from 7.5 to 15 years) whose arithmetic skills levels were assessed, leading to a combined sample of n=536. Across the whole sample, we found a unique positive relation between arithmetic skills and grey matter volume (GMV) in the left inferior frontal gyrus. We also found positive relations between GMV and arithmetic skills in the bilateral temporal cortex in adolescents. In sum, our results highlight brain-wide associations between arithmetic skills and GMV of perisylvian regions, suggesting a role for language processing in individual differences in arithmetic skills.
A double-threshold score of serum pepsinogen combined with serum albumin improves the screening ability of peptic ulcer
Authors: Wang Binli , Zhang Zheyu , Jin Weili , Chen Haojun , Wang Linfeng , Xu Min , Hou Chaoqun , Zhiquan Qian , Qiu Ziyue , Zhang Sheng
Published: December 2022

Background and purpose: Quickly screening of high-risk of peptic ulcer (PU) is of great significance to avoid gastrointestinal bleeding after antiplatelet therapy. In this study, we hoped to find a fast and less invasive method for PU screening.
Methods: The clinical data of health examined population who were admitted for taking gastroscopic assessment in our hospital, from January 2019 to June 2020, was prospectively collected. PU was defined as a gastric or duodenal mucosal defect >5mm in diameter on gastroscopic assessment.
Results: A total of 902 blood samples were enrolled into analysis. Blood indices showed that PGI and albumin (ALB) were both independently associated with PU (all P<0.05). Based on this, we proposed a PGI and ALB Composite Score (PACS), ranged from 0-2. The ROC analysis showed that PACS had a good diagnostic ability for PU (AUC=0.774, P<0.001). The probability of PU was significantly elevated with the increase of PACS score (PACS 0 vs 1 vs 2=7.9% vs 28.6% vs 62.2%, P<0.001).
Conclusion: Both serum PGI and ALB were associated with the increased rate of PU in health examined population, and the PACS score based on these two items may be used to identify the population with high risk of PU.
Prevalence and Associated Factors of COPD among Hypertensive Patients aged 40 Years or Older in China, 2014 -15
Authors: Zhao Yanfang , Fang Liwen , Wang Zhuoqun , Fan Jing , Cong Shu , Wu Jing
Published: December 2022

Background
COPD and hypertension not only share some risk factors, but also interact in terms of disease progression and death. There are about 300 million hypertensive patients in China, but there is a scarcity of evidence on the prevalence and associated factors of COPD in hypertension population. This study aimed to analyze the prevalence and associated factors of COPD among hypertensive patients in China.
Methods
Data were collected as part of a large-scale and nationally representative sample survey conducted in 125 counties (districts) in 31 provinces (autonomous regions and municipalities) of mainland China aged 40 or above, 2014 -15, which consisted of 24,664 hypertensive patients. The prevalence and associated factors of COPD were analyzed among hypertensive patients population using the Chi-square test and multivariate logistic regression model.
Results
The prevalence of COPD among hypertensive patients aged ≥ 40 years was 15.6% (95% confidence interval [95% CI],0.15–0.16), with a prevalence of 21.9% (95% CI,0.21–0.23) for men and 9.0% (95% CI,0.08–0.10) for women. Among the hypertensive patients, the prevalence of COPD was significantly higher in those who were male (odds ratio [OR], 2.05; 95% CI, 1.82–2.31), aged 70 years or older (OR, 6.00; 95% CI, 5.09–7.01), underweight (OR, 1.54; 95% CI, 1.18–2.05), current smoker(OR, 1.72; 95% CI, 1.53–1.93), with hospital admission due to severe pulmonary diseases in childhood (OR, 1.82; 95% CI, 1.41–2.36), history of tuberculosis (OR, 1.39; 95% CI, 1.08–1.79), with family history of lung diseases (OR, 1.64; 95% CI, 1.50–1.80), with indoor exposure to biomass for cooking or heating (OR, 1.10; 95% CI, 1.01–1.21), and with exposure to dust /chemicals in the workplace (OR, 1.20; 95% CI, 1.10–1.30), compared with their counterparts.
Conclusions
The prevalence of COPD is high in hypertensive patients aged 40 or above in China, which is associated with male gender, older age, less education, low weight, smokers, disease or family history of lung-related diseases, and exposure to dust /chemicals or biofuels. It would be of value to carry out health education, screening and comorbidity co-management for COPD relying on the hypertension community-based health management service among hypertensive patients aged 40 or above.
How are radiologists' decisions impacted by AI suggestions? Moderating effect of explainability inputs and attitudinal priming in examining mammograms
Authors: Mehrizi Mohammad H. Rezazade , Mol Ferdinand , Peter Marcel , Ranschaert Erik , Santos Daniel Pinto Dos , Shahidi Ramin , Fatehi Mansoor , Dratsch Thomas
Published: December 2022

Various studies have shown that medical professionals are prone to follow the incorrect suggestions offered by algorithms, especially when they have limited informational inputs to interrogate and interpret such suggestions and when they have an attitude of relying on them. We examine the effect of correct and incorrect algorithmic suggestions on the diagnosis performance of radiologists when 1) they have no, partial, and extensive informational inputs for explaining the suggestions (study 1) and 2) they are primed to hold a positive, negative, ambivalent, or neutral attitude towards AI (study 2). Our analysis of 2760 decisions made by 92 radiologists conducting 15 mammography examinations show that radiologists' diagnoses follow both incorrect and correct suggestions, despite variations in the explainability inputs and attitudinal priming interventions. We identify and explain various pathways through which radiologists navigate through the decision process and arrive at correct or incorrect decisions. Overall, the findings of both studies show the limited effect of using explainability inputs and attitudinal priming for overcoming the unintended influence of (incorrect) algorithmic suggestions.
Assistive devices use as coping strategy of frailty management: a cross-sectional study
Authors: Yu Shiqi , Luo Di , Zou Hongyan , Liu Tong , Zhou Lu , Xiao Mingzhao
Published: December 2022

Background: Frailty has been described as the most problematic expression in the context of considerable aging progression. Moreover, frailty-associated disability severely affects individuals and the society. Evidence has suggested that assistive devices (ADs) usage can slow functional decline, improve dependency and well-being with aging. Considering there is a paucity of published evidence on elderly assistive aids for the management of frailty, the present study aimed to shed light on the potential mediating effect of assistive devices usage on the frailty through the relationship between frailty and disability, and provide a theoretical basis for a health behavior intervention for frailty.
Methods: Convenience sampling method was used to select 335 older adults aged over 60 years using the FRAIL scale and the Barthel index for Activities of Daily living (ADL). Pearson’s r correlations were used to examine the association between the frailty, disability and assistive devices use and structural equation modelling (SEM) was to test a hypothetical mediation model.
Results: Of the 335 sample aged 60 or older, the participants’ mean age was 70.8 years old (SD = 6.6), mean scores of frailty and ADL disability was 2.71 (SD = 1.3) and 50.39 (SD = 24.5), respectively. Merely 21.8% of the participants were using ADs. Pearson’s ranalsysi demonstrated that ADL disability and ADs use were significantly correlated with frailty. Lastly, ADs use mediated the relationship between frailty and disability.
Conclusions: This study demonstrates that ADs usage may potentially serve as a tool for frailty management by mediating the association between frailty and disability. However, at present, ADs usage rate is rather low at the context of amounting rates of frailty. Therefore, the routine assessment of frailty and prescription of elderly assistive products are crucial when designing and implementing health promotion programme for elderly persons.
ab initio determination of molecular geometry AND vibrational frequencies of benzotrifluoride
Authors: Kushwaha Anita , Prasad R. L. Prasad Ram Lakhan , Yadav R. A. Yadavc Ram Ajore
Published: December 2022

Using Gaussian 05 Revision C.02 version of the quantum chemical program ab initio computations has been carried out to compute optimized geometry, harmonic vibrational frequencies along with intensities in IR and Raman spectra and atomic charges at rhf / 6–31 + g*, b3lyp / 6–31 + + g** and b3lyp / 6–311 + + g** levels. The optimized molecular structure is found to possess Cs point group symmetry with the plane of symmetry passing through the C atom, to which the CF3 group is attached, the centrally opposite C atom and the C atom of the CF3 group and perpendicular to the phenyl ring plane. One of the three F atoms of the CF3 group is found to be on one side of the ring plane and is situated on the plane of the symmetry while the other two F atoms are found to be on the other side of the ring plane placed symmetrically on either side of the symmetry plane. Vibrational assignments for the normal modes have been reviewed. To make vibrational assignments for the normal modes of vibration the Gauss View software was used. The CF3 group has the characteristic frequencies in the 340, 768, 1072, 1152 and 1318 cm− 1 which are due to the modes δs(CF3), νs(CF3), νas(CF3) (a’), νas(CF3) (a”) and ν(C–CF3) respectively. The torsional frequency of the CF3 group is found to be 16 cm− 1 which would lead to barrier height of ~ 0.5 kJ / mol for the torsional motion of the CF3 group.