bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Phase Transformations and Strength Properties of Nanostructured (1 − x)ZrO2 − xCeO2 Composite Ceramics
Authors: Berguzinov Askhat , Kozlovskiy Artem , Khametova Ainagul A. , Shlimas Dmitriy I.
Published: June 2022

The aim of this work is to study the properties of nanostructured (1 − x)ZrO2 − xCeO2 composite ceramics, depending on the content of oxide components, as well as to establish the relationship between the phase composition of ceramics and strength properties. The choice of (1− x)ZrO2 − xCeO2 composite ceramics as objects of study is due to the great prospects for using them as the basis for inert matrix materials for nuclear dispersed fuel, which can replace traditional uranium fuel in high-temperature nuclear reactors. Using X-ray diffraction, it was found that the variation of the oxide components leads to phase transformations of the Monoclinic-ZrO2 → Monoclinic − Zr0.98Ce0.02O2/Tetragonal − ZrO2 → Tetragonal − Zr0.85Ce0.15O2 → Tetragonal − ZrCeO4/Ce0.1Zr0.9O2 type. As a result of mechanical tests, it was found that the formation of tetragonal phases in the structure of ceramics leads to strengthening of ceramics and an increase in crack resistance, which is due not only to an increase in the crystallinity degree, but also to the effect of dislocation hardening associated with a decrease in grain size. It has been established that a change in the phase composition due to phase transformations and displacement of the ZrO2 phase from the ceramic structure with its transformation into the phase of partial replacement of Zr0.85Ce0.15O2 or Ce0.1Zr0.9O2 leads to the strengthening of ceramics by more than 3.5–4 times. The results of resistance to crack formation under single compression showed that the formation of the ZrCeO4 phase in the structure of ceramics leads to an increase in the resistance of ceramics to cracking by more than 2.5 times.
Redispersible Reduced Graphene Oxide Prepared in a Gradient Solvent System
Authors: Sheng Yitian , Zhou Youliang , Tang Changwei , Cheng Xiangnan , Zhang Chaocan
Published: June 2022

We designed a gradient solvent strategy for the reduction of graphene oxide, matching the hydrophilic properties of graphene oxide (GO) and reduced graphene oxide (RGO), respectively. A third solvent was added dropwise to regulate the hydrophilic variation of the continuous gradient system which maintained the whole reduction process without aggregation, and the obtained RGO dispersions could maintain stability for a long time. The separated RGO solid powder can be directly ultrasonically redispersed in N-methyl-pyrrolidone (NMP) with an average particle size as low as 200 nm. Furthermore, RGO with a high C/O ratio of 13.75 was prepared on the basis of the gradient solvent system. Using different structures of dispersants and polymers as representatives, we employed successive solvent rinsing, thermal solvent extraction, and thermal treatment to study adsorption and desorption. It was found that the above measures differed significantly in the removal of surface sorbates. The selected fatty alcohol polyoxyethylene ether (AEO) series achieved a good balance between the system dispersion and surface adsorbate removal. The conductivity was originally 5236 S m−1, and it increased from 9024 to 18,000 S m−1 after thermal treatment at 300 and 500 °C, respectively.
Automated Quantum Dots Purification via Solid Phase Extraction
Authors: Lüdicke Malín G. , Hildebrandt Jana , Schindler Christoph , Sperling Ralph A. , Maskos Michael
Published: June 2022

The separation of colloidal nanocrystals from their original synthesis medium is an essential process step towards their application, however, the costs on a preparative scale are still a constraint. A new combination of approaches for the purification of hydrophobic Quantum Dots is presented, resulting in an efficient scalable process in regard to time and solvent consumption, using common laboratory equipment and low-cost materials. The procedure is based on a combination of solvent-induced adhesion and solid phase extraction. The platform allows the transition from manual handling towards automation, yielding an overall purification performance similar to one conventional batch precipitation/centrifugation step, which was investigated by thermogravimetry and gas chromatography. The distinct miscibility gaps between surfactants used as nanoparticle capping agents, original and extraction medium are clarified by their phase diagrams, which confirmed the outcome of the flow chemistry process. Furthermore, the solubility behavior of the Quantum Dots is put into context with the Hansen solubility parameters framework to reasonably decide upon appropriate solvent types.
Twisted Bands with Degenerate Points of Photonic Hypercrystals in Infrared Region
Authors: Zheng Yaoxian , Wang Qiong , Lin Mi , Bibbò Luigi , Ouyang Zhengbiao
Published: June 2022

Photonic hypercrystals (PHCs) are materials combining hyperbolic metamaterials (HMMs) with widely used photonic crystals. We found that finite-sized Type-I HMMs can support unique electromagnetic modes, which could be utilized in two-dimensional photonic crystals to achieve PHCs with twisted bands in the infrared region. Numerical investigation of the PHCs showed that the twisted bands have degenerate points that can support all-angle self-collimation effects. The behaviors of light beams change dramatically in such bands, which provides an effective method in controlling light propagation and can be applied as switching. The effect of the filling factor and the permittivity of the dielectric medium of the HMM on the twisted bands were studied. Furthermore, by considering the nonlinear effect of the dielectric layers, an all-optical switch working on the PHC twisted bands is proposed, which has low switching power and high extinction ratio (19.75 dB), superior to conventional HMM switches that require type transformation of metamaterial.
Integration of Micro-Nano-Engineered Hydroxyapatite/Biochars with Optimized Sorption for Heavy Metals and Pharmaceuticals
Authors: Zhao Xin , Yuan Peiling , Yang Ziyan , Peng Wei , Meng Xiang , Cheng Jiang
Published: June 2022

From the perspective of treating wastes with wastes, bamboo sawdust was integrated with a hydroxyapatite (HAP) precursor to create engineered nano-HAP/micro-biochar composites (HBCs) by optimizing the co-precipitated precursor contents and co-pyrolysis temperature (300, 450, 600 °C). The physicochemical properties of HBCs, including morphologies, porosities, component ratios, crystalline structures, surface elemental chemical states, surface functional groups, and zeta potentials as a function of carbonization temperatures and components of precursors, were studied. Biochar matrix as an efficient carrier with enhanced specific surface area to prevent HAP from aggregation was desired. The sorption behavior of heavy metal (Cu(II), Cd(II), and Pb(II)) and pharmaceuticals (carbamazepine and tetracycline) on HBCs were analyzed given various geochemical conditions, including contact time, pH value, ionic strength, inferencing cations and anions, coexisting humic acid, and ambient temperature. HBCs could capture these pollutants efficiently from both simulated wastewaters and real waters. Combined with spectroscopic techniques, proper multiple dominant sorption mechanisms for each sorbate were elucidated separately. HBCs presented excellent reusability for the removal of these pollutants through six recycles, except for tetracycline. The results of this study provide meaningful insight into the proper integration of biochar–mineral composites for the management of aquatic heavy metals and pharmaceuticals.
Nano-Silica-Modified Concrete: A Bibliographic Analysis and Comprehensive Review of Material Properties
Authors: Khan Kaffayatullah , Ahmad Waqas , Amin Muhammad Nasir , Nazar Sohaib
Published: June 2022

Several review studies have been performed on nano-silica-modified concrete, but this study adopted a new method based on scientometric analysis for the keywords’ assessment in the current research area. A scientometric analysis can deal with vast bibliometric data using a software tool to evaluate the diverse features of the literature. Typical review studies are limited in their ability to comprehensively and accurately link divergent areas of the literature. Based on the analysis of keywords, this study highlighted and described the most significant segments in the research of nano-silica-modified concrete. The challenges associated with using nano-silica were identified, and future research is directed. Moreover, prediction models were developed using data from the literature for the strength estimation of nano-silica-modified concrete. It was noted that the application of nano-silica in cement-based composites is beneficial when used up to an optimal dosage of 2–3% due to high pozzolanic reactivity and a filler effect, whereas a higher dosage of nano-silica has a detrimental influence due to the increased porosity and microcracking caused by the agglomeration of nano-silica particles. The mechanical strength might enhance by 20–25% when NS is incorporated in the optimal amount. The prediction models developed for predicting the strength of nano-silica-modified concrete exhibited good agreement with experimental data due to lower error values. This type of analysis may be used to estimate the essential properties of a material, therefore saving time and money on experimental tests. It is recommended to investigate cost-effective methods for the dispersion of nano-silica in higher concentrations in cement mixes; further in-depth studies are required to develop more accurate prediction models to predict nano-silica-modified concrete properties.
Label-Free Morpho-Molecular Imaging for Studying the Differential Interaction of Black Phosphorus with Tumor Cells
Authors: Mussi Valentina , Fasolino Ines , Paria Debadrita , De Simone Sara , Caporali Maria , Serrano-Ruiz Manuel , Ambrosio Luigi , Barman Ishan , Raucci Maria Grazia , Convertino Annalisa
Published: June 2022

Black phosphorus nanosheets (2D BP) are emerging as very promising, highly selective chemotherapeutic agents due to their fast degradation in the intracellular matrix of cancer cells. Here, optical diffraction tomography (ODT) and Raman spectroscopy were exploited as a powerful label-free approach to achieve integrated insights into the processes accompanying the administration of exfoliated 2D BP flakes in human prostatic adenocarcinoma and normal human prostate epithelial cells. Our ODT experiments provided unambiguous visualization of the 2D BP internalization in cancer cells and the morphological modifications of those cells in the apoptotic phase. The cellular internalization and damaging occurred, respectively, 18 h and 36–48 h after the 2D BP administration. Changes in the chemical properties of the internalized 2D BP flakes were monitored by Raman spectroscopy. Interestingly, a fast oxidation process of the 2D BP flakes was activated in the intracellular matrix of the cancer cells after 24 h of incubation. This was in sharp contrast to the low 2D BP uptake and minimal chemical changes observed in the normal cells. Along with the understanding of the 2D BP fate in the cancer cells, the proposed label-free morpho-molecular approach offers a powerful, rapid tool to study the pharmacokinetic properties of engineered nanomaterials in preclinical research.
MoO3@MoS2 Core-Shell Structured Hybrid Anode Materials for Lithium-Ion Batteries
Authors: Faizan Muhammad , Hussain Sajjad , Islam Mobinul , Kim Ji-Young , Han Daseul , Bae Jee-Hwan , Vikraman Dhanasekaran , Ali Basit , Abbas Saleem , Kim Hyun-Seok , Singh Aditya Narayan , Jung Jongwan , Nam Kyung-Wan
Published: June 2022

We explore a phase engineering strategy to improve the electrochemical performance of transition metal sulfides (TMSs) in anode materials for lithium-ion batteries (LIBs). A one-pot hydrothermal approach has been employed to synthesize MoS2 nanostructures. MoS2 and MoO3 phases can be readily controlled by straightforward calcination in the (200–300) °C temperature range. An optimized temperature of 250 °C yields a phase-engineered MoO3@MoS2 hybrid, while 200 and 300 °C produce single MoS2 and MoO3 phases. When tested in LIBs anode, the optimized MoO3@MoS2 hybrid outperforms the pristine MoS2 and MoO3 counterparts. With above 99% Coulombic efficiency (CE), the hybrid anode retains its capacity of 564 mAh g−1 after 100 cycles, and maintains a capacity of 278 mAh g−1 at 700 mA g−1 current density. These favorable characteristics are attributed to the formation of MoO3 passivation surface layer on MoS2 and reactive interfaces between the two phases, which facilitate the Li-ion insertion/extraction, successively improving MoO3@MoS2 anode performance.
Substrate-Modulated Electric and Magnetic Resonances of Lithium Niobite Nanoparticles Illuminated by White Light
Authors: Li Hui , Peng Yigeng , Lu Ruifeng
Published: June 2022

The manipulation of light at the nanoscale is important for nanophotonic research. Lithium niobite (LiNbO3), as an ideal building block for metamaterials, has attracted great interest for its unique properties in the field of nonlinear optics. In this paper, we numerically studied the effect of different substrates on the optical resonances of a LiNbO3 nanoparticle. The results show that the electric and magnetic resonances of such a system can be effectively adjusted by changing the substrate. Compared to the impact of dielectric substrate, the interaction between the LiNbO3 nanoparticle and the Au film shows a fascinating phenomenon that a sharp resonance peak appears. The multipole decomposition of the scattering spectrum shows that the size, shape of the LiNbO3 nanoparticle, and the thickness of the SiO2 film between the particle and the Au film have a significant impact on the electromagnetic resonance of the LiNbO3 nanoparticle. This work provides a new insight into LiNbO3 nanoparticles, which may have potential use in the design of dielectric nanomaterials and devices.
Unique Interaction between Layered Black Phosphorus and Nitrogen Dioxide
Authors: Zhao Jingjing , Zhang Xuejiao , Zhao Qing , Yu Xue-Feng , Zhang Siyu , Xing Baoshan
Published: June 2022

Air pollution caused by acid gases (NO2, SO2) or greenhouse gases (CO2) is an urgent environmental problem. Two-dimensional nanomaterials exhibit exciting application potential in air pollution control, among which layered black phosphorus (LBP) has superior performance and is environmentally friendly. However, the current interaction mechanism of LBP with hazardous gases is contradictory to experimental observations, largely impeding development of LBP-based air pollution control nanotechnologies. Here, interaction mechanisms between LBP and hazardous gases are unveiled based on density functional theory and experiments. Results show that NO2 is different from other gases, as it can react with unsaturated defects of LBP, resulting in oxidation of LBP and reduction of NO2. Computational results indicate that the redox is initiated by p orbital hybridization between one oxygen atom of NO2 and the phosphorus atom carrying a dangling single electron in a defect’s center. For NO, the interaction mechanism is chemisorption on unsaturated LBP defects, whereas for SO2, NH3, CO2 or CO, the interaction is dominated by van der Waals forces (57–82% of the total interaction). Experiments confirmed that NO2 can oxidize LBP, yet other gases such as CO2 cannot. This study provides mechanistic understanding in advance for developing novel nanotechnologies for selectively monitoring or treating gas pollutants containing NO2.
Influence of Critical Parameters on Cytotoxicity Induced by Mesoporous Silica Nanoparticles
Authors: Ahmadi Amirsadra , Sokunbi Moses , Patel Trisha , Chang Ming-Wei , Ahmad Zeeshan , Singh Neenu
Published: June 2022

Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed to be satisfactory, is unclear. Physicochemical properties of MSNs, such as diameter size, morphology, and surface charge, control their biological interactions and toxicity. Experimental conditions also play an essential role in influencing toxicological results. Therefore, the present study includes studies from the last five years to statistically analyse the effect of various physicochemical features on MSN-induced in-vitro cytotoxicity profiles. Due to non-normally distributed data and the presence of outliers, a Kruskal–Wallis H test was conducted on different physicochemical characteristics, including diameter sizes, zeta-potential measurements, and functionalisation of MSNs, based on the viability results, and statistical differences were obtained. Subsequently, pairwise comparisons were performed using Dunn’s procedure with a Bonferroni correction for multiple comparisons. Other experimental parameters, such as type of cell line used, cell viability measurement assay, and incubation time, were also explored and analysed for statistically significant results.
γ-Valerolactone Production from Levulinic Acid Hydrogenation Using Ni Supported Nanoparticles: Influence of Tungsten Loading and pH of Synthesis
Authors: Córdova-Pérez Gerardo E. , Cortez-Elizalde Jorge , Silahua-Pavón Adib Abiu , Cervantes-Uribe Adrián , Arévalo-Pérez Juan Carlos , Cordero-Garcia Adrián , de los Monteros Alejandra E. Espinosa , Espinosa-González Claudia G. , Godavarthi Srinivas , Ortiz-Chi Filiberto , Guerra-Que Zenaida , Torres-Torres José Gilberto
Published: June 2022

γ-Valerolactone (GVL) has been considered an alternative as biofuel in the production of carbon-based chemicals; however, the use of noble metals and corrosive solvents has been a problem. In this work, Ni supported nanocatalysts were prepared to produce γ-Valerolactone from levulinic acid using methanol as solvent at a temperature of 170 °C utilizing 4 MPa of H2. Supports were modified at pH 3 using acetic acid (CH3COOH) and pH 9 using ammonium hydroxide (NH4OH) with different tungsten (W) loadings (1%, 3%, and 5%) by the Sol-gel method. Ni was deposited by the suspension impregnation method. The catalysts were characterized by various techniques including XRD, N2 physisorption, UV-Vis, SEM, TEM, XPS, H2-TPR, and Pyridine FTIR. Based on the study of acidity and activity relation, Ni dispersion due to the Lewis acid sites contributed by W at pH 9, producing nanoparticles smaller than 10 nm of Ni, and could be responsible for the high esterification activity of levulinic acid (LA) to Methyl levulinate being more selective to catalytic hydrogenation. Products and by-products were analyzed by 1H NMR. Optimum catalytic activity was obtained with 5% W at pH 9, with 80% yield after 24 h of reaction. The higher catalytic activity was attributed to the particle size and the amount of Lewis acid sites generated by modifying the pH of synthesis and the amount of W in the support due to the spillover effect.
High Gas Sensitivity to Nitrogen Dioxide of Nanocomposite ZnO-SnO2 Films Activated by a Surface Electric Field
Authors: Petrov Victor V. , Ivanishcheva Alexandra P. , Volkova Maria G. , Storozhenko Viktoriya Yu. , Gulyaeva Irina A. , Pankov Ilya V. , Volochaev Vadim A. , Khubezhov Soslan A. , Bayan Ekaterina M.
Published: June 2022

Gas sensors based on the multi-sensor platform MSP 632, with thin nanocomposite films based on tin dioxide with a low content of zinc oxide (0.5–5 mol.%), were synthesized using a solid-phase low-temperature pyrolysis technique. The resulting gas-sensitive ZnO-SnO2 films were comprehensively studied by atomic force microscopy, Kelvin probe force microscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, scanning transmission electron microscopy, energy dispersive X-ray spectrometry, and X-ray photoelectron spectroscopy. The obtained films are up to 200 nm thick and consist of ZnO-SnO2 nanocomposites, with ZnO and SnO2 crystallite sizes of 4–30 nm. Measurements of ZnO-SnO2 films containing 0.5 mol.% ZnO showed the existence of large values of surface potential, up to 1800 mV, leading to the formation of a strong surface electric field with a strength of up to 2 × 107 V/cm. The presence of a strong surface electric field leads to the best gas-sensitive properties: the sensor’s responsivity is between two and nine times higher than that of sensors based on ZnO-SnO2 films of other compositions. A study of characteristics sensitive to NO2 (0.1–50 ppm) showed that gas sensors based on the ZnO-SnO2 film demonstrated a high sensitivity to NO2 with a concentration of 0.1 ppm at an operating temperature of 200 °C.
Buffer Components Incorporate into the Framework of Polyserotonin Nanoparticles and Films during Synthesis
Authors: Jeon Keuna , Asuncion Justin Andrei , Corbett Alexander Lucien , Yuan Tiange , Patel Meera , Andoy Nesha May Octavio , Kreis Christian Titus , Voznyy Oleksandr , Sullan Ruby May Arana
Published: June 2022

Polyserotonin nanoparticles (PSeNP) and films are bioinspired nanomaterials that have potential in biomedical applications and surface coatings. As studies on polyserotonin (PSe) nanoparticles and films are still in their infancy, synthetic pathways and material development for this new class of nanomaterial await investigation. Here, we sought to determine how different buffers used during the polymerization of serotonin to form nanoparticles and films impact the physicochemical properties of PSe materials. We show that buffer components are incorporated into the polymer matrix, which is also supported by density functional theory calculations. While we observed no significant differences between the elasticity of nanoparticles synthesized in the different buffers, the nanoscale surface properties of PSe films revealed dissimilarities in surface functional groups influenced by solvent molecules. Overall, the results obtained in this work can be used towards the rational design of PSe nanomaterials with tailored properties and for specific applications.
The Role of miR-217-5p in the Puromycin Aminonucleoside-Induced Morphological Change of Podocytes
Authors: Ishibashi Osamu , Hayashi Mika , Horikawa Aya , Owada Hitoshi , Miyamoto Ryotaro , Mizukami Naoya , Inui Takashi
Published: June 2022

Podocytes, alternatively called glomerular epithelial cells, are terminally differentiated cells that wrap around glomerular capillaries and function as a part of the glomerular filtration barrier in the kidney. Therefore, podocyte injury with morphological alteration and detachment from glomerular capillaries leads to severe proteinuria and subsequent renal failure through glomerulosclerosis. Previous RNA sequencing analysis of primary rat podocytes exposed to puromycin aminonucleoside (PAN), a well-known experimental model of injured podocytes, identified several transcripts as being aberrantly expressed. However, how the expression of these transcripts is regulated remains unclear. MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally inhibit the expression of their target transcripts. In this study, using small RNA sequencing analysis, miR-217-5p was identified as the most upregulated transcript in PAN-treated rat podocytes. MiR-217-5p overexpression in E11 podocyte cells led to shrunken cells with abnormal actin cytoskeletons. Consistent with these changes in cell morphology, gene ontology (GO) enrichment analysis showed that interactive GO terms related to cell morphogenesis were enriched with the predicted targets of miR-217-5p. Of the predicted targets highly downregulated by PAN, Myosin 1d (Myo1d) is a nonmuscle myosin predicted to be involved in actin filament organization and thought to play a role in podocyte morphogenesis and injury. We demonstrated that miR-217-5p targets Myo1d by luciferase assays, qRT–PCR, and Western blotting. Furthermore, we showed that miR-217-5p was present in urine from PAN- but not saline-administrated rats. Taken together, our data suggest that miR-217-5p may serve as a therapeutic target and a biomarker for podocyte injury.
Potential Impact of Learning Management Zones for Site-Specific N Fertilisation: A Case Study for Wheat Crops
Authors: Franco Camilo , Mejía Nicolás , Pedersen Søren Marcus , Gislum René
Published: June 2022

This paper proposes an automatic, machine learning methodology for precision agriculture, aiming at learning management zones that allow a more efficient and sustainable use of fertiliser. In particular, the methodology consists of clustering remote sensing data and estimating the impact of decision-making based on the extracted knowledge. A case study is developed on experimental data coming from winter wheat (Triticum aestivum) crops receiving site-specific fertilisation. A first approximation to the data allows measuring the effects of the fertilisation treatments on the yield and quality of the crops. After verifying the significance of such effects, clustering analysis is applied on sensor readings on vegetation and soil electric conductivity in order to automatically learn the best configuration of zones for differentiated treatment. The complete methodology for identifying management zones from vegetation and soil sensing is validated for two experimental sites in Denmark, estimating its potential impact for decision-making on site-specific N fertilisation.
Metabolic Dysfunction-Associated Fatty Liver Disease Is Associated with the Risk of Incident Cardiovascular Disease: A Prospective Cohort Study in Xinjiang
Authors: Guo Yanbo , Yang Jing , Ma Rulin , Zhang Xianghui , Guo Heng , He Jia , Wang Xinping , Cao Boyu , Maimaitijiang Remina , Li Yu , Peng Xinyu , Zhang Shijie , Guo Shuxia
Published: June 2022

In 2020, a group of international experts proposed a new term ‘metabolic dysfunction-associated fatty liver disease’ (MAFLD) to replace ‘non-alcoholic fatty liver disease’. This study aimed to describe the epidemic characteristics of MAFLD, incidence of cardiovascular disease (CVD), and relationship between MAFLD and incident CVD. In 2016, 12,794 Uyghur adults from Kashgar, Xinjiang, were grouped according to the presence or absence of MAFLD. The primary outcome was the occurrence of CVD events. Fatty liver was diagnosed using ultrasound. The prevalence of MAFLD was 16.55%. After excluding patients with previous CVD, 11,444 participants were followed up for a median period of 4.7 years. During the follow-up period, the overall CVD incidence was 10.40% (1190/11,444). The incidence of CVD in the patients with MAFLD was significantly higher than that in the non-MAFLD patients (18.38% vs. 9.02%, p < 0.001; multivariable-adjusted hazard ratio = 1.37, 95% CI = 1.20–1.56). The prevalence of MAFLD was relatively low, whereas the incidence of CVD was relatively high among the Uyghur adults in rural Xinjiang. Individuals with MAFLD have a higher risk of developing CVD independent of traditional cardiovascular risk factors, obesity, type 2 diabetes mellitus (T2DM), and dyslipidaemia.
Serum 25-hydroxyvitamin D Concentration Significantly Decreases in Patients with COVID-19 Pneumonia during the First 48 Hours after Hospital Admission
Authors: Smaha Juraj , Kužma Martin , Jackuliak Peter , Nachtmann Samuel , Max Filip , Tibenská Elena , Binkley Neil , Payer Juraj
Published: June 2022

It is unclear how ongoing inflammation in Coronavirus Disease 2019 (COVID-19) affects 25-hydroxyvitamin D (25[OH]D) concentration. The objective of our study was to examine serum 25(OH)D levels during COVID-19 pneumonia. Patients were admitted between 1 November and 31 December 2021. Blood samples were taken on admission (day 0) and every 24 h for the subsequent four days (day 1–4). On admission, 59% of patients were 25(OH)D sufficient (>30 ng/mL), and 41% had 25(OH)D inadequacy (<30 ng/mL). A significant fall in mean 25(OH)D concentration from admission to day 2 (first 48 h) was observed (30.7 ng/mL vs. 26.4 ng/mL; p < 0.0001). No subsequent significant change in 25(OH)D concentration was observed between day 2 and 3 (26.4 ng/mL vs. 25.9 ng/mL; p = 0.230) and day 3 and day 4 (25.8 ng/mL vs. 25.9 ng/mL; p = 0.703). The absolute 25(OH)D change between hospital admission and day 4 was 16% (4.8 ng/mL; p < 0.0001). On day 4, the number of patients with 25(OH)D inadequacy increased by 18% (p = 0.018). Therefore, serum 25(OH)D concentration after hospital admission in acutely ill COVID-19 patients should be interpreted with caution. Whether low 25(OH)D in COVID-19 reflects tissue level vitamin D deficiency or represents only a laboratory phenomenon remains to be elucidated in further prospective trials of vitamin D supplementation.
Methodological Aspects in Randomized Clinical Trials of Nutritional Interventions
Authors: Martínez-López Erika , Pérez-Guerrero Edsaúl Emilio , Torres-Carrillo Nora Magdalena , López-Quintero Andres , Betancourt-Núñez Alejandra , Gutiérrez-Hurtado Itzae Adonai
Published: June 2022

Nutrition is an essential component when promoting human health. Without a doubt, improving the quality of one’s diet can improve one’s quality of life as a whole and help postpone the onset or control of many chronic diseases. The volume of publications in this field has increased in recent years, in line with increased awareness of the importance of nutrition in health; however, the quality of the evidence on which most nutritional guidelines are based remains low, due to errors in conducting nutritional interventions or because the information is primarily derived from observational studies. To enhance the evidence supporting clinical guidelines in nutrition, the quality of randomized clinical trials (RCT) based on nutritional interventions must be improved; nevertheless, due to their heterogeneous nature and a lack of specific guidelines for designing, performing, documenting, and reporting on this type of intervention, conducting a nutritional intervention is a real challenge. Following a review of the literature on the methodological and ethical standards, as well as four extensions of the CONSORT (Consolidated Standards of Reporting Trials) guidelines that should be considered when implementing a nutritional intervention, seven essential aspects were identified. The current narrative review includes definitions, examples, diagrams, and algorithms regarding aspects of the appropriate study design, the intervention of the control group, the randomization and blinding processes, the study population selection, as well as a description of the type of intervention and the personnel involved in carrying out the study in order to make the implementation of a nutritional intervention easier.
Exploring the Path of Mediterranean Diet, Non-Alcoholic Fatty Liver Disease (NAFLD) and Inflammation towards 10-Year Cardiovascular Disease (CVD) Risk: The ATTICA Study 10-Year Follow-Up (2002–2012)
Authors: George Elena S. , Georgousopoulou Ekavi N. , Mellor Duane D. , Chrysohoou Christina , Pitsavos Christos , Panagiotakos Demosthenes B.
Published: June 2022

Background: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease, affecting ~30% of the population and increasing CVD. This study aimed to explore the direct, indirect and combined effects of Mediterranean diet, NAFLD and inflammation on the 10-year CVD risk in a healthy adult population. Methods: Using baseline and 10-year follow-up data from the ATTICA study, adherence to Mediterranean diet was measured using MedDietScore, and presence of NAFLD at baseline was assessed using the fatty liver index (FLI). Participants’ 10-year CVD outcomes were recorded and C-reactive protein (CRP) was used as a surrogate marker for inflammation. The direct and indirect roles of these factors were explored using logistic regression models and the pathways between them were analysed using a structural equation model (SEM). Results: NAFLD prevalence was 22.9% and its presence was 17% less likely for every unit increase in MedDietScore. NAFLD presence at baseline was associated with increased 10-year CVD incidence (39.4% vs. 14.5%, p = 0.002), but when adjusted for MedDietScore, NAFLD was not an independent predictor of 10-year CVD risk. MedDietScore was an independent protective factor of 10-year CVD risk (OR = 0.989, 95% CI: 0.847, 0.935), when adjusted for NAFLD at baseline, age, gender, sedentary lifestyle and other confounders. Further exploration using SEM showed that MedDietScore was associated with CVD risk directly even when inflammation as CRP was introduced as a potential mediator. Conclusion: FLI as a proxy measure of NAFLD is a strong predictor of 10-year CVD risk, and this prognostic relationship seems to be moderated by the level of adherence to Mediterranean diet. Adherence to Mediterranean diet remained an independent and direct CVD risk factor irrespective of NAFLD status and CRP.
Use of the Baby-Led Weaning (BLW) Method in Complementary Feeding of the Infant—A Cross-Sectional Study of Mothers Using and Not Using the BLW Method
Authors: Białek-Dratwa Agnieszka , Soczewka Monika , Grajek Mateusz , Szczepańska Elżbieta , Kowalski Oskar
Published: June 2022

Baby-led weaning (BLW) is an increasingly popular way of expanding a baby’s diet. It is based on the baby becoming physically ready to feed himself, effectively supplementing his diet, which until now has been based on breast milk or modified milk. The aim of the study was to assess mothers’ knowledge about the use of the BLW method to expand the diet of a young child. The essence of the study assumed the analysis of the advantages and disadvantages of using this method indicated by mothers. Materials and Methods: A total of 320 mothers participated in the study. Data for the study were collected anonymously using the CAWI method. The research tool was the original questionnaire relating to the knowledge about the BLW method and the application of the BLW method in practice. Results: The BLW method was used by 240 (75%) women. The reasons for not using the BLW method were: the child did not cooperate n = 30 (37.5%) and was not ready to use the BLW method n = 20 (25%). In total, 182 (75.8%) mothers using BLW and 63 (78.8%) mothers not using BLW started extending the diet before the child was 6 months old. According to 270 (84.4%) mothers, including 205 (85.4%) using BLW, stable sitting in a highchair/on the lap is a decisive factor for starting the dietary expansion with the BLW method. Conclusions: Mothers’ knowledge of the BLW method as a way of expanding a young child’s diet was insufficient. It seems important to implement appropriate educational activities on the methods of expanding children’s diets to broaden parents’ knowledge of the influence of nutrition on infant development.
Selenium Status in Paediatric Patients with Neurodevelopmental Diseases
Authors: Görlich Christian L. , Sun Qian , Roggenkamp Viola , Hackler Julian , Mehl Sebastian , Minich Waldemar B. , Kaindl Angela M. , Schomburg Lutz
Published: June 2022

Neurodevelopmental diseases are often associated with other comorbidities, especially inflammatory processes. The disease may affect the trace element (TE) status, which in turn may affect disease severity and progression. Selenium (Se) is an essential TE required for the biosynthesis of selenoproteins including the transporter selenoprotein P (SELENOP) and extracellular glutathione peroxidase (GPX3). SELENOP deficiency in transgenic mice resulted in a Se status-dependent phenotype characterized by impaired growth and disturbed neuronal development, with epileptic seizures on a Se-deficient diet. Therefore, we hypothesized that Se and SELENOP deficiencies may be prevalent in paediatric patients with a neurodevelopmental disease. In an exploratory cross-sectional study, serum samples from children with neurodevelopmental diseases (n = 147) were analysed for total serum Se, copper (Cu), and zinc (Zn) concentrations as well as for the TE biomarkers SELENOP, ceruloplasmin (CP), and GPX3 activity. Children with epilepsy displayed elevated Cu and Zn concentrations but no dysregulation of serum Se status. Significantly reduced SELENOP concentrations were found in association with intellectual disability (mean ± SD (standard deviation); 3.9 ± 0.9 mg/L vs. 4.4 ± 1.2 mg/L, p = 0.015). A particularly low GPX3 activity (mean ± SD; 172.4 ± 36.5 vs. 192.6 ± 46.8 U/L, p = 0.012) was observed in phacomatoses. Autoantibodies to SELENOP, known to impair Se transport, were not detected in any of the children. In conclusion, there was no general association between Se deficiency and epilepsy in this observational analysis, which does not exclude its relevance to individual cases. Sufficiently high SELENOP concentrations seem to be of relevance to the support of normal mental development. Decreased GPX3 activity in phacomatoses may be relevant to the characteristic skin lesions and merits further analysis. Longitudinal studies are needed to determine whether the observed differences are relevant to disease progression and whether correcting a diagnosed TE deficiency may confer health benefits to affected children.
Liver Metastatic Breast Cancer: Epidemiology, Dietary Interventions, and Related Metabolism
Authors: Zuo Qianying , Park Nicole Hwajin , Lee Jenna Kathryn , Madak Erdogan Zeynep
Published: June 2022

The median overall survival of patients with metastatic breast cancer is only 2–3 years, and for patients with untreated liver metastasis, it is as short as 4–8 months. Improving the survival of women with breast cancer requires more effective anti-cancer strategies, especially for metastatic disease. Nutrients can influence tumor microenvironments, and cancer metabolism can be manipulated via a dietary modification to enhance anti-cancer strategies. Yet, there are no standard evidence-based recommendations for diet therapies before or during cancer treatment, and few studies provide definitive data that certain diets can mediate tumor progression or therapeutic effectiveness in human cancer. This review focuses on metastatic breast cancer, in particular liver metastatic forms, and recent studies on the impact of diets on disease progression and treatment.
Liver Damage Is Related to the Degree of Being Underweight in Anorexia Nervosa and Improves Rapidly with Weight Gain
Authors: Cuntz Ulrich , Voderholzer Ulrich
Published: June 2022

Background: The present study investigates the relationship between hypertransaminasemia and malnutrition on the basis of a very large number of patients. We assume that the level of transaminases not only reflects the extent of underlying liver cell damage but also provides information about the metabolic situation under conditions of energy deficiency. Methods: We present an observational study in two different samples. The first sample consists of 3755 patients (mean age 22.7 years, Range 12–73 years; mean BMI 15.4 kg/m2, range 8.1–25.7) out of a total of 4212 patients with anorexia nervosa treated in the Roseneck Clinic within five years for whom a complete admission laboratory was available. The second sample was obtained from a special ward for medically at-risk patients with eating disorders. During the period in question, four hundred and ten patients with anorexia nervosa were treated. One hundred and forty-two female patients (mean age 26.4 years, Range 18–63 years; mean BMI 11.5 kg/m2, range 8.4–13) had a BMI of thirteen or less and a complete data set was obtained at admission and weekly in the following four weeks after admission. Results: The increase in liver transaminases shows a very high correlation with weight in sample one (N = 3755). The analysis of variance shows highly significant (<0.001) correlations with an F-value of 55 for GOT/AST and 63 for GPT/ALT. Nevertheless, the variance within the groups with the same BMI is quite high. With re-nutrition in sample two, GOT/AST decreased on average from 71 U/L to 26 U/L (MANOVA F 10.7, p < 0.001) and GPT/ALT from 88 to 41 U/L (F = 9.9, p < 0.001) within four weeks. Discussion: Below a BMI of about 13, the nutritional status of the patients becomes so critical that the energy supply of the patient is increasingly dependent on the autophagy of the liver, which can be seen in the very strong increase in transaminases here. Refeeding leads very quickly to the normalisation of the transaminases and, thus, a stabilisation of the metabolism leading also to a decrease in autophagy.
Very Low-Calorie Ketogenic Diet: A Potential Application in the Treatment of Hypercortisolism Comorbidities
Authors: Guarnotta Valentina , Emanuele Fabrizio , Amodei Roberta , Giordano Carla
Published: June 2022

A very low-calorie ketogenic diet (VLCKD) is characterized by low daily caloric intake (less than 800 kcal/day), low carbohydrate intake (<50 g/day) and normoproteic (1–1.5 g of protein/kg of ideal body weight) contents. It induces a significant weight loss and an improvement in lipid parameters, blood pressure, glycaemic indices and insulin sensitivity in patients with obesity and type 2 diabetes mellitus. Cushing’s syndrome (CS) is characterized by an endogenous or exogenous excess of glucocorticoids and shows many comorbidities including cardiovascular disease, obesity, type 2 diabetes mellitus and lipid disorders. The aim of this speculative review is to provide an overview on nutrition in hypercortisolism and analyse the potential use of a VLCKD for the treatment of CS comorbidities, analysing the molecular mechanisms of ketogenesis.
Analysis of Dietary Habits and Nutritional Status of Children with Down Syndrome in the Context of Lipid and Oxidative Stress Parameters
Authors: Wernio Edyta , Kłosowska Anna , Kuchta Agnieszka , Ćwiklińska Agnieszka , Sałaga-Zaleska Kornelia , Jankowski Maciej , Kłosowski Przemysław , Wiśniewski Piotr , Wierzba Jolanta , Małgorzewicz Sylwia
Published: June 2022

Introduction: The risk of obesity in children with Down syndrome is high. Undoubtedly, proper nutrition plays an important role in the prevention of excess body weight and is associated with a reduction of metabolic complications. The aim of the study was to assess the problem of disturbances in the nutritional status and eating habits of children with DS. Methods: A total of 39 patients were included in the study. The nutritional status was assessed by anthropometric tests and Dual X-ray Absorptiometry. Eating habits were assessed using the Child Eating Behavior Questionnaire and the Food Frequency Questionnaire. Blood samples were taken to determine the oxidative stress and lipid parameters. Results: Obesity was recognized in 15% of subjects and 23% were overweight. Children that were overweight were characterized by higher levels of triglycerides, atherogenic index of plasma, and apoA2 and apoE levels. Fat mass, fat mass/height2 index, and visceral fat mass correlated with thiobarbituric acid reactive substances and advanced oxidative protein product level. The analysis of the Child Eating Behavior Questionnaire showed that children struggling with being overweight were more interested in food compared to those with normal body weight. A positive correlation was identified between waist circumference and food interest categories. Insufficient consumption of dairy products, vegetables, whole grain products, as well as fruits, seeds, nuts, and fatty fish was noted. Patients were less likely to consume products that are a good source of mono- and polyunsaturated fatty acids. Conclusions: In children with Down syndrome and obesity, disturbances in lipid and oxidative stress parameters are observed. Abnormal eating habits in all children with Down syndrome regardless of their nutritional status were noted. Proper nutritional education, nutritional control, and management of metabolic problems are essential in this group of patients.
Context Matters: Preliminary Evidence That the Association between Positive Affect and Adiposity in Infancy Varies in Social vs. Non-Social Situations
Authors: Wood Alexis C. , Momin Shabnam R. , Senn MacKenzie K. , Bridgett David J.
Published: June 2022

Previous studies have suggested that infants high in negative affect have higher levels of adiposity, arising in part via changes in nutrition (e.g., “feeding to soothe”). Few studies have examined whether positive affect shows similar or inverse associations with adiposity. The current study examined cross-sectional and longitudinal relationships between adiposity and observations of positive affect in both a social and a non-social context, using data from infants at four (n = 125) and 12 (n = 80) months of age. Our analyses did not find any cross-sectional associations between positive affect and adiposity (all p > 0.05). However, in the longitudinal analyses, positive affect in a non-social context, when observed at four months of age, was positively associated with weight-for-length at 12 months of age (zWFL; ß = 1.49, SE = 0.67, p = 0.03), while positive affect observed at four months of age in a social context was inversely associated with body fat percentage at 12 months of age (ß = −11.41, SE = 5.44, p = 0.04). These findings provide preliminary evidence that the p positive affect is related to adiposity in infancy and suggest that the direction of association (i.e., direct or inverse) may be specific to the context in which positive affect is measured. Future research should examine the role of nutritional status in any relationships between adiposity and emotion at this early stage.
Experiences of Carers and People with Dementia from Ethnic Minority Groups Managing Eating and Drinking at Home in the United Kingdom
Authors: Nair Pushpa , Barrado-Martín Yolanda , Anantapong Kanthee , Moore Kirsten , Smith Christina , Sampson Elizabeth , Manthorpe Jill , Walters Kate , Davies Nathan
Published: June 2022

Eating and drinking difficulties, such as loss of appetite and swallowing problems, are common in dementia, but little is known about the experiences of ethnic minority groups who are managing these difficulties at home. The purpose of our study was to explore the meaning of food, the impact of dementia on eating and drinking, and carers’ experiences of support. We undertook semi-structured interviews with 17 carers and people with dementia from ethnic minority backgrounds living in England, using thematic analysis to analyse the data. Food/drink had strong links to identity, culture and emotions. Providing culturally familiar foods, celebrating traditional festivals and supporting previous food-related roles promoted reminiscence, which encouraged the people living with dementia to eat and drink, as did social interactions, although these could lead to distress in those with more advanced dementia. Food choices were also influenced by carer strain, generational differences and the impact of health conditions. Despite a strong sense of duty to care for relatives at home, there was low awareness of community support services. The carers expressed a need for culturally tailored support for managing dementia-related eating and drinking difficulties at home. Healthcare professionals must provide contextually relevant advice to carers, being mindful of how cultural backgrounds can affect dietary choices.
Natural Products and Disease Prevention, Relief and Treatment
Authors: Islam Md Soriful
Published: June 2022

This Special Issue focusses on the role of natural products in disease prevention, relief and treatment [...]