bluuebunny/crossref_metadata_2025 huggingface dataset:
O batismo no Novo Testamento
Authors: de Sousa Marques Mariosan
Published: July 2023

Esta obra é fruto de uma pesquisa sobre as práticas batismais no Novo Testamento, com enfoque para o batismo cristão, enfocando a linguagem simbólica presente na liturgia dos sacramentos. São discutidos o mistério, o sentido de celebrar, a dimensão simbólica da liturgia e a natureza dos sacramentos. O batismo é analisado em diversos aspectos, desde seu vocabulário bíblico até seu significado no Novo Testamento e sua prática como rito. Também são abordados o batismo de João Batista, o batismo de Jesus e sua importância, os batismos nos Atos dos Apóstolos, na literatura paulina e o na primeira carta de Pedro. O texto explora as diferentes perspectivas e significados do batismo dentro do contexto religioso cristão.
A Quantitative Analysis of Economic Factors of Revolutionary Destabilization: Results and Prospects
Authors: Korotaev A. V. , Zhdanov A. I.
Published: July 2023

There are certain grounds for asserting that the fifth generation of revolution theories is being formed in the 21st century. The main distinguishing features of the new generation of theories of revolution seem to be the reliance on global databases of revolutionary events, the widespread use of modern methods of quantitative analysis, and the fundamental idea that armed and unarmed revolutionary events are characterized by fundamentally different factors, structure and consequences. At the same time, revolutions / maximalist campaigns are understood as “series of observable, continuous, targeted mass tactics pursuing fundamental changes in the political order: regime change or national self-determination” (E. Chenoweth). This article opens a series of reviews of the main concrete results obtained within the research of this generation, which opens with an analysis of the economic factors of revolutionary destabilization identified within the framework of this approach. Quantitative cross-national studies of the economic factors of revolutionary destabilization carried out to date (which we refer to as the fifth generation of studies of revolutions) show that the same economic factors can have very different effects on the likelihood of the outbreak of armed uprisings, on the one hand, and unarmed revolutionary actions, on the other. These studies show that the likelihood of unarmed revolutionary uprisings is higher in middle income countries without oil revenues, against the backdrop of rapidly rising food prices (whereas both recession and economic recovery can provoke such uprisings). On the other hand, armed uprisings are most likely in the poorest raw-material-based economies against the backdrop of an economic downturn and falling investment in fixed assets.
Specificities of Hybrid Risk Formation in the Russian Public Sphere
Authors: Nikiforov A. A.
Published: July 2023

Contemporary research in social science often turns to the problem of the hybridization of politics: analyzing the “gray zone” between authoritarianism and democracy; defining the role of new media, and understanding informal practices in restoring peace in post-conflict societies. The contribution of the present article is based on an investigation of the concept of risk hybridization to explore the reflection on risk in the public sphere for the state, social movements, and citizens. The sociology of U. Beck with the theory of reflexive modernization — as well as the concept of cosmopolitics — are used to explore different effects of risk hybridization models (diffusion, dominance, breakdown of hierarchy and causation) for the public sphere and politics. The author used materials on the COVID-19 epidemic — practices of the Russian state and the change of mass consciousness — to analyze interrelations between the process of risk hybridization and decrease in the coherence of state institutions and the transformation of political alienation in Russian society. The relationship between risk hybridization models and the formation of collective cognitive maps is considered through the practice of framing social movements and protest campaigns. Said nexus is illustrated by the Russian cases of social movements and specific public claims of mass protests actions in 2019-2020. The state governance perspective is used as an framework for a discussion of the effects of risk hybridization on limitations of deliberative and authoritarian models for managing of risk, as well as its perception by social groups. In the conclusion, the author highlights the high cost of maintaining the consistency of reflection on risk in the model of managing (authoritarian) knowledge. Moreover, the author discusses the rising complexity of social reality and the spread of digital media that multiplies reflection on risk.
Psychological Factors Underlying Attitudes toward War: A Theoretical Review
Authors: Gulevich O. A. , Osin E. N.
Published: July 2023

People have different attitudes toward military action as a way of resolving international conflicts. In this article we will examine the psychological approach to the study of these attitudes: (a) the levels of attitudes toward war (attitudes toward specific military campaigns vs. general attitude toward war as a way of resolving international conflicts); (b) psychological (individual, social-psychological, and situational) factors predicting these attitudes; (c) limitations of the existing research and directions for future research. We will focus on three social-psychological factors predicting attitudes toward military action on the territory of other states: social identities (common human identity vs national identity, secured national identity vs national narcissism), attitudes toward political authority (right-wing authoritarianism, political trust), and the perceived threat from adversary countries. We will show that common human identity is negatively related to the attitudes toward military companies, whereas national identity (especially national narcissism), positive attitudes toward political authorities (primarily right-wing authoritarianism), and perceived intergroup threat are positively related to them. In this review we will discuss the results obtained in various countries, primarily in the USA, several European countries, and Russia.
ANALISIS KARAKTER KEPEMIMPINAN DAN KEBERANIAN OERIP SOEMOHARDJO DALAM BUKU “OERIP SOEMOHARDJO BAPAK TENTARA YANG DILUPAKAN”
Authors: Anggelia Foni Refika , Wahyuni Anny
Published: July 2023

Penelitian ini bertujuan untuk mengetahui bagaimana karakter kepemimpinan dan keberanian dari Oerip Soemohardjo, seorang jendral dan kepala staf umum TNI pada masa Revolusi. Penelitian ini didasari oleh kerisauan penulis tentang generasi muda yang semakin hari memiliki karakter yang jauh dari kata baik, untuk itu penulis memberikan deskripsi mengenai karakter kepemimpinan dan keberanian dari seorang Oerip Soemorhardjo yang jarang dimiliki oleh generasi muda saat ini. Minimnya informasi mengenai Oerip Soemohardjo pun menambah tidak dikenalnya tokoh pahlawan tersebut. Penelitian ini menggunakan metode sejarah dengan pendekatan studi pustaka dalam mengumpulkan, memperoleh dan mengolah data secara kritis sehingga dapat menghasilkan informasi yang sesuai dengan fakta dilapangan. Dari penelitian ini didapatkan bahwa karakter kepemipinan dan keberanian dari Oerip Soemohardjo serta kerja keras yang dilakukan oleh beliau yang akhirnya menjadi awal mula bangkitnya dunia militer di Indonesia hingga akhirnya terbentuk Organisasi Tentara Nasional Indonesia (TNI).
MENELADANI KARAKTER PRAMOEDYA ANANTA TOER MELALUI TULISAN-TULISANNYA DALAM MEMPERJUANGKAN KEMERDEKAAN INDONESIA
Authors: Lukita Welda , Indrayani Nelly
Published: July 2023

Kemerdekaan Indonesia adalah peristiwa yang sangat bersejarah bagi bangsa Indonesia. Indonesia bisa mencapai kemerdekaan karena hasil jerih payah yang dilakukan oleh para pahlawan. Para pahlawan ini tidak hanya yang terjun langsung ke medan perang tetapi dalam dunia intelektual seperti sastra pun juga dikatakan sebagai pahlawan. Seperti yang dilakukan oleh seorang sastrawan Indonesia bernama Pramoedya Ananta Toer. Pramoedya ialah sastrawan terkenal dan ternama karena banyak karya-karya yang dihasilkannya terlebih untuk memperjuangkan kemerdekaan Indonesia walaupun ia dalam kondisi tertekan sekalipun. Pramoedya memiliki nilai karakter jujur, patriotisme, toleran, dan humanis. Ini sangat patut dijadikan teladan bagi generasi muda sekarang ini.
ARSIP MUSEUM GENTALA ARASY DARI ANALOG KE DIGITAL
Authors: Indrayani Nelly
Published: July 2023

Arsip menjadi bagian penting dalam penulisan sejarah. Bagaikan dua sisi mata uang membangun penulisan sejarah diperlukan sumber sejarah arsip. Kelangkaan dan kesulitan mendapatkan arsip, diperlukan tranformasi arsip dari bentuk analog atau konvensional kebentuk digital. Metode yang digunakan dalam penelitian ini adalah melalui empat tahapan, yaitu heristik/ pengumpulan sumber-sumber sejarah/ data, kritik sumber, interpretasi (penafsiran) dan historiografi (penulisan sejarah). Dalam rangka mendapatkan data primer dan sekunder tersebut maka dilakukan studi pustaka (library research) dan studi lapangan (field research). Terutama studi pustaka ke perpustakaan Universitas Jambi, perpustakaan Fakultas Ilmu Budaya Universitas Jambi, koleksi pribadi peneliti dan berita, jurnal dan artikel. Sedangkan penelitian lapangan lebih mengandalkan metode observasi dan wawancara. Hasil penelitian menunjukkan bahwa Digitalisasi menjadi bagian penting dalam pengelolaan manajemen kearsipan. Perubahan sistem dari analog ke digital pada arsip dapat meningkatkan kinerja produktivitas, inovasi dan efesiensi. Arsip digital dari bentuk analog ke bentuk digital memberikan kemudahan akses setiap pengunjung Museum yang berasal dari daerah manapun dan dari suku apapun. Misalanya Palembang, Kerinci, Lubuk Linggau, dan Sumatera Barat. Hal ini menjadikan digitalisasi arsip merupakan sebuah wahana interaksi edukasi dan budaya
PERSEPSI SISWA TERHADAP MODEL PEMBELAJARAN SEJARAH BERBASIS MOBILE MATERI PERDAGANGAN ANTARPULAU SUMATERA DAN JAWA ABAD KE 13-16 MASEHI DI SMK TELENIKA PALEMBANG
Authors: Abidin Rahman
Published: July 2023

Persepsi adalah suatu proses kegiatan yang didasari dari hasil pengamatan seseorang terhadap suatu objek yang diamati berupa tanggapan yang disampaikan dalam bentuk lisan ataupun tulisan serta dapat mempengaruhi nilai suatu objek yang diamati. Persepsi siswa sangatlah penting untuk dapat diketahui dalam sebuah penilaian. Masalah dalam penelitian ini adalah bagaimanakah persepsi siswa terhadap model pembelajaran sejarah berbasis mobile materi perdagangan antarpulau Sumatera dan Jawa abad ke13-16 masehi di kelas 10 Sekolah Menengah Kejuruan Telenika Palembang. Tujuan dari penelitian ini untuk mengetahui dan mendeskripsikan persepsi siswa terhadap model pembelajaran sejarah berbasis mobile materi perdagangan antarpulau Sumatera dan Jawa abad ke13-16 masehi. Metode penelitian yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Teknik pengumpulan data melalui wawancara, observasi, dokumentasi dan angket. Teknik Aalisis Data menggunakan Analisis deskriptif kualitatif. Dari hasil penelitian ini didapatkan data persepsi siswa dengan rata-rata persentase yaitu 95,63%, dilihat dari ketiga indikator yaitu menerima, memahami dan menilai atau respon menunjukkan bahwa persepsi siswa memilih setuju dan sangat setuju dengan kategori sangat baik. Dengan demikian, model pembelajaran sejarah berbasis mobile dapat meningkatkan kualitas pembelajaran yang lebih efektif dan mudah diterima siswa guna pencapaian hasil belajar yang lebih baik dan lebih maksimal.
MOTIF JEPANG SEBELUM MENGINVANSI HINDIA BELANDA TAHUN 1942-1945
Authors: Nurohmat Anah
Published: July 2023

Jepang juga dikenal dengan Nippon pernah menancapkan hagemoni di Hindia Belanda antara tahun 1942-1945. Hakko Ichiu sebagai falsafah/ideologi Jepang saat itu memiliki makna mendalam bagi ekspansi Jepang ke Hindia Belanda. Nippon bercita-cita menjadi penguasa asia timur raya dan menyatukan negara-negara asia di bawah kekuasaannya. Artikel ini bertujuan menjelaskan motif Jepang menguasai Hindia Belanda baik motif internal dan motif eksternal. Hasil dari artikel ini adalah beberapa motif Jepang menginvansi Hindia Belanda yaitu terdapat faktor eksternal yang dipengaruhi dari luar dan motif interna berasal dari dalam negeri Jepang untuk menginvansi Indonesia. Penulis menggunakan metode pengumpulan sumber berupa studi literatur dan penulisan deskriptif-naratif. Diharapkan tulisan ini menyumbang dan memperkaya kajian sejarah pergerakkan nasional yang berkaitan dengan invansi Jepang ke Hindia Belanda.
PERAN ORGANISASI PERHIMPUNAN INDONESIA DALAM UPAYA MENCAPAI KEMERDEKAAN DI BELANDA
Authors: Rusdiana Yusinta Tia , Heryati Heryati , Yuliarni Yuliarni
Published: July 2023

Penelitian ini bertujuan untuk mengetahui peran organisasi Perhimpunan Indonesia dalam upaya mencapai kemerdekaan.  Metode yang digunakan dalam penelitian ini adalah metode sejarah atau historis dengan tahapan: heuristik, kritik, interpretasi, dan historiogtafi. Jenis Penelitian yang digunakan bersifat kajian pustaka (literature). Hasil penelitian menjelaskan (1) Latar belakangi berdirinya organisasi Perhimpunan Indonesia di Belanda karena adanya motivasi untuk menjalin rasa persatuan dan kekeluargaan hidup di rantauan, juga adanya rasa kesadaran Nasional yang timbul, setelah banyak belajar tentang sejarah perjuangan dari berbagai negara di dunia. (2) Peranan organisasi Perhimpunan Indonesia dalam upaya mencapai  kemerdekaan di Belanda sebagai tempat pergerakan para mahasiswa Indonesia di Belanda, sebagai bentuk penyampai tentang nama Indonesia kepada dunia umumnya dan khususnya kepada rakyat Indonesia yang ada di tanah air.
Performance Measurement Supply Chain Management (SCM) Using the Supply Chain Operation Reference (SCOR) Method at PT X
Authors: Hidayati Alfi , Pulansari Farida
Published: July 2023

In the world of the fertilizer industry in Indonesia, there are some of problems in the process of planning, procurement and, delivery of materials that adversely affect the company's operations. One approach to fixing this problem is to use a SCOR strategy that is effective in improving the supply chain. PT. X is one of the fertilizer companies whose current condition is that there are problems in planning to meet the needs for production supporting materials so which has the potential to hinder fertilizer production. This is because PT X has not carried out an analysis that hinders demand planning or the supply chain as a whole. Thus, researchers can measure the value of effectiveness in the supply chain to improve targets that have not been achieved. In this research, a scoring method called SCOR was used which included AHP weighting. Fifteen key performance indicators (KPI) were generated based on the five SCOR model indicators used in processing, namely data plan, source, make, delivery, and return. With a final score of the SCM performance level of 86.872, which is included in the Good category. However, this value can still be improved so that it is included in the excellent category, namely >90. So inecessary to identify KPI indicators that have performance values that are not yet optimal, and to make suggestions for improvements to increase PT X SCM performance values.
The Impact of Pro-Environment Belief and Personal Norm toward the Beauty Purchase Behavior
Authors: Ikhsan Ridho Bramulya , Br Sinukaban Laranza Destami , Dinegoro Radindya Citta , Annur Rania Ramadhanty , Fernando Yudi
Published: July 2023

Objectives: The increasing use of eco-friendly beauty products in Indonesia attracts many researchers to understand buying behavior. Therefore, this study examines the effect of altruistic values, hedonic values, pro-environmental beliefs, personal norms, and independent decision-making on consumer buying behavior of eco-friendly beauty products.Methodology: This research is quantitative with an online survey of consumers purchasing green cosmetics products in Greater Jakarta, Indonesia. The determination of the number of samples is ten times the number of indicators with a purposive sampling technique. The research questionnaire was developed by several prior researchers who had been tested for validity and reliability. Structural equation modeling uses structural equation modeling-partial lease squares with SmartPLS software version 4 to test the research hypothesis.Finding: The results of the study show that altruistic values and hedonic values have a positive effect on pro-environmental beliefs. Furthermore, pro-environmental beliefs have a positive effect on personal norms. Finally, personal norms and independent judgment-making positively affect consumers' purchase behavior of green beauty products in Greater Jakarta.Conclusion: Green beauty purchase behavior in Greater Jakarta is influenced by personal norms and independent judgment-making which are also influenced by altruistic values, hedonic values, and pro-environmental beliefs. In the context of green beauty products, awareness that arises from within oneself can form a better level of consistency in buying green beauty product behavior. The findings from this study serve as a basis for managers and the Indonesian government to implement better eco-friendly strategies to motivate consumers to buy green products, especially cosmetics.
The Influence of Digital Talent and Green Innovation and Its Impact on the MSME Business Model in the Metaverse Era
Authors: Reniati Reniati , Bidayani Endang , Sumiyati Sumiyati
Published: July 2023

Objectives: The study aims to look at MSME Business Models Entering the Metaverse Era Through Digital Transformation with an Increase of Digital Talent and Green InnovationMethodology: The type of research used is quantitative research. A study was carried out in 5 regencies/cities on Bangka Island with respondents 10 2 SMEs, dominated in the culinary sector. In this study, the author uses the analytical method used to test the PLS (Partial Least Square) variable using SmartPLS software. The path analysis model of all latent variables in Partial Least Square (PLS) consists of an outer model, convergent validity, and discriminant validity which is then carried out with a reliability test and a structural model consisting of coefficient of determination (R 2 Value), Effect Size (f 2), and Predictive Relevance (Q2 Value). Ending with a test on the hypothesis and the moderating effect.Conclusion: The results of this study indicate that hypothesis testing concluded that two research hypotheses are accepted and the other three are rejected. The accepted research hypotheses are Digital Talent effect on Digital Transformation and Digital Talent effect on MSME Business Model in the Metaverse Era. These results indicate that only digital talent currently contributes significantly to Digital Transformation and the MSME business model in the metaverse Era.
Learning Difficulties and Students' Ability Level During Pandemic Covid-19 on The Subject of Thermochemistry
Authors: Agustina Rizza R. T. , Afadil Afadil , Rahmawati Sitti , Tiwow Vanny M. A.
Published: July 2023

This study aims to identify learning difficulties learning experienced by students on the subject thermochemistry in class XI IPA SMA Negeri 8 Palu during the Covid-19 pandemic for the 2021 / 2022 school year. The instruments used in this study are thermochemistry tests, questionnaires, and interviews. The result showed students’ difficulties in the subject thermochemistry in class XI IPA was 60 %, the highest difficulty of students is found in the thermochemistry test of calculating the heat of the type of compound, calculating enthalpy changes, and formulating steps and hypotheses of an experiment. The difficulty is indicated by the low level of student comprehension of 54 %, medium 43 %, and high 3 % with an average of 30%. Furthermore, the difficulty of students in participating in chemistry learning during the Covid-19 pandemic is technical difficulties with a percentage of 65.92 %, difficulties in implementing learning with a percentage 0f 65.44 %, and external difficulties (environment and parents) with a percentage of 52.92 %. based on these results, the learning difficulties experienced by students during chemistry learning thermochemistry subjects during the Covid-19 pandemic include students often being constrained by signals and quotas to access materials on the internet and do not have student handbooks to study at home, difficulty understanding chemistry concepts because teacher explanations are elusive, students are not active in participating in learning because chemistry learning during the pandemic is not interesting, can’t afford chemistry books and quotas also parents don’t provide motivation and students are often lazy to do assignments because no one helps with doing. The result of this study indicates that the level of students' difficulties learning about thermochemistry is a quite high category with a low level of student ability and students agree that it is difficult to study chemistry during the pandemic Covid-19.
Determination of Secondary Metabolites and Antioxidant Activity of Robusta Coffee Bean Ethanol Extract by UV - Vis Spectrophotometry
Authors: Tandi Joni , Riani Ni P. I. , Handayani Tien W. , Kanan Maria
Published: July 2023

Robusta coffee beans (Coffea canephora Pierre ex.A.Froehner) have antioxidant, antidiabetic, and antihypertensive effects and can prevent coronary heart disease. This study aims to determine the compound content and total levels of secondary metabolites and to determine the antioxidant activity of robusta coffee bean extract. UV - Vis spectrophotometer was used to determine the total levels of secondary metabolites and antioxidant assay using DPPH reagent. The results obtained for the positive qualitative test contain secondary metabolites of alkaloids, flavonoids, saponins, and tannins and do not contain steroid compounds while for the quantitative test, the total alkaloid content is 0.1973%w/w (caffeine equivalent), flavonoids are 1.2106 % w / w (equivalent to quercetin), saponins 0.536 % w / w (equivalent to sapogenins), tannins at 9.7103 % w / w (equivalent to tannic acid). The IC50 result for the antioxidant activity of the ethanolic extract of robusta coffee beans is 55.16 µg/ml which is included in the category of strong antioxidants.
A Phase I study to evaluate the safety, tolerance and pharmacokinetics of anti-Shiga toxin hyperimmune equine F(ab’)2 fragments in healthy volunteers
Authors: Hiriart yanina , Scibona Paula , Ferraris Augusto , Belloso Waldo , Beruto Valeria , Garcia-Bournissen Facundo , Zylberman Vanesa , Muñoz Luciana , Goldbaum Fernando , Spatz Linus , Colonna Mariana , Sanguineti Santiago , Simonovich Ventura
Published: July 2023

Shiga toxin-producing Escherichia coli-associated hemolytic uremic
syndrome (STEC-HUS) is considered a toxemic disorder in which early
intervention with neutralizing antibodies may have therapeutic benefits.
INM004, composed of F(ab’) fragments from equine
immunoglobulins, neutralizes Stx1/Stx2, potentially preventing the onset
of HUS. A single-center, randomized, Phase 1, single-blind,
placebo-controlled clinical trial to evaluate INM004 safety, tolerance,
and pharmacokinetics (PK) in healthy adult volunteers, was conducted; In
Stage I, eight subjects were divided in two cohorts (n=4) to receive a
single INM004 dose of 2 or 4 mg.kg-1, or placebo (INM004:placebo rate
3:1). In Stage II six subjects received either three INM004 doses of 4
mg.kg-1 repeated every 24 h, or placebo (INM004:placebo rate of 5:1).
Hospital discharged was 24 hours after the last infusion. INM004 was
quantified by ELISA in serum samples obtained at predefined times.
Safety and tolerability were assessed in both Stages by monitoring
adverse events (AEs), laboratory test values, and vital signs. Eight
subjects (57.1%) experienced treatment-emergent AEs (TEAEs), that
resolved within 24 hours without requiring changes in treatment or
additional intervention. No serious AEs were reported. Most TEAEs were
of mild or moderate intensity, and four were possibly drug-related. Peak
concentrations (C) of INM004 were 45.1 µg.mL-1 and
77.7 µg.mL-1 for different doses, within two hours after infusion. The
serum concentration declined in a biphasic manner (t
range 30.7-52.9 hours). Systemic exposures showed accumulation in the
repeated dose regimen (C Day1 85.7 vs.149 µg.mL-1
Day3). These results supporting progression into the phase 2 trial in
children with HUS
Phase 1 Study of Cabozantinib in Combination with Topotecan- Cyclophosphamide for Patients with Relapsed Ewing Sarcoma or Osteosarcoma
Authors: Campbell Kevin , Posner Andrew , Chen Nan , Cavanaugh Kerri , Bhushan Ketki , Janeway Katherine , Shulman David , George Suzanne , Klega Kelly , Crompton Brian , London Wendy , DuBois Steven
Published: July 2023

Purpose Phase 1 study assessing the safety and toxicity of
cabozantinib in combination with topotecan and cyclophosphamide for
relapsed osteosarcoma and Ewing sarcoma. Methods Oral
cabozantinib (25mg/m ) was administered daily for 21
(dose level 1) or 14 (dose level -1B) days. Topotecan (0.75mg/m
) and cyclophosphamide (250mg/m )
were administered IV on days 1-5. A modified 3+3 design based upon first
cycle dose-limiting toxicities (DLT) was used for dose escalation.
Results Twelve patients with a median age of 15 (12.9-33.2) years
were enrolled (7 with Ewing sarcoma; 5 with osteosarcoma); all were
evaluable for toxicity. At dose level 1, three of six patients developed
first cycle DLT: grade 3 epistaxis; grade 3 transaminitis; prolonged
grade 2 thrombocytopenia. Six patients were enrolled on dose level -1B
(interrupted cabozantinib, given days 8-21), with one first cycle DLT
(grade 3 pneumothorax) observed. Of the 10 response evaluable patients,
one had partial response (Ewing sarcoma), seven had stable disease, and
two had progressive disease. Conclusions The recommended phase 2
doses and schedules for this combination are topotecan 0.75mg/m
IV days 1-5, cyclophosphamide 250mg/m
IV days 1-5, and cabozantinib 25mg/m
days 8-21. Non-concomitant administration of
cabozantinib with cytotoxic therapy in this population has acceptable
toxicity while allowing for potential disease control.
Mapping Damages from Inspection Images to 3D Digital Twins of Large-Scale Structures
Authors: Benzon Hans-Henrik von , Chen Xiao
Published: July 2023

This study develops a methodology to create detailed visual Digital
Twins of large-scale structures with their realistic damages detected
from visual inspection or nondestructive testing (NDT). The methodology
is demonstrated with a transition piece of an offshore wind turbine and
a composite rotor blade, with surface paint damage and subsurface
delamination damage, respectively. Artificial Intelligence and color
threshold segmentation are used to classify and localize damages from
optical images taken by drones. These damages are digitalized and mapped
to a three-dimensional geometry reconstruction of the large-scale
structure or a CAD model of the structure. To map the images from 2D to
3D, metadata information is combined with the geo placement of the
large-scale structure’s 3D model. After mapping the damage, the Digital
Twin gives an accurate representation of the structure. The location,
shape, and size of the damage are visible on the Digital Twin. The
demonstrated methodology can be applied to industrial sectors such as
wind energy, the oil and gas industry, marine and aerospace to
facilitate asset management.
Guilty in absentia ‒ Cytomegalovirus seropositivity relates inversely to cancer incidence in race/ethnicity groups and worldwide: is latent viral infection oncopreventive?
Authors: Janković Marko , Milicevic Ognjen , Todorović-Balint Milena , Đunić Irena , Mihaljević Biljana , Jovanovic Tanja , Knezevic Aleksandra
Published: July 2023

Background. Race and ethnic disparities in cancer incidence
rates and the prevalence of cytomegalovirus (CMV) are known to
exist in the United States (U.S.) but also across broad geographic
expanses. The prevalence of CMV seems to inversely contrast rates of
tumor incidence both in ethnic groups and globally. Is there a
biological link between cancer and CMV infection? Methods.
Global cancer data were retrieved from the World Health Organization
(WHO) database. Incidence of cancer and CMV seroprevalence (73
countries) were subjected to Spearman’s correlation test. The Bayesian
framework was adopted for CMV seropositivity variables. Cancer incidence
and CMV pervasiveness in the U.S. were extracted from publications based
on the Surveillance, Epidemiology, and End Results (SEER) registries and
the National Health and Nutrition Examination Surveys (NHANES),
1988-2004. Results. An inversely directed coupling between
cancer and CMV seropositivity across diverse ecologies and cultural
domains suggest a global oncoprotective effect of the CMV (Spearman’s
ρ = -0.732; p<0.001). Rates of all cancers
combined and CMV seropositivity show an opposite association (
p<0.001) among the races and foremost U.S. ethnic
groups. Conclusion. The racial/ethnic incidence of cancers and
CMV seropositivity are inversely proportional both in the U.S. and
globally. This would support a view that CMV is a potential driver
against tumorigenesis. An absence of CMV infection abrogates protection
against malignant clones afforded by the virus to an infected host.
Abating CMV seroprevalence may relate causally to the buildup of
malignancies in U.S. and the West world countries with thriving hygiene
and healthcare systems.
Strategies to relieve intraluminal obstructions in inaccessible segments of the ascending, transverse, and descending colon
Authors: Dechant Julie
Published: July 2023

Enteroliths, faecaliths, ingested foreign bodies, and bezoars are
examples of focal intraluminal obstructions that can lodge in
inaccessible parts of the gastrointestinal tract. Pneumatic lithotripsy,
as described in the accompanying article, is an option to manage
obstructions caused by mineralized concretions. However, pneumatic
lithotripsy may not be safe or effective for all intraluminal
obstructions. Awareness of other strategies or secondary abdominal
approaches to address these challenging presentations can help improve
the surgeon’s ability to problem solve in these situations and achieve
successful resolution of the obstruction.
Effect and mechanism of Allergen Specific Immunotherapy (AIT) on small airway dysfunction in children with asthma
Authors: Wu Jinhong , zhong wenwei , Ying Xiaolan , Zhang Lei , Dong Wenfang , Lin Jie , Yang Lin , Yin Yong , Hong Li
Published: July 2023

Background: Small airway dysfunction (SAD) is a common problem in
childhood asthma patients despite of asthma control therapy. The
effectiveness and mechanism of allergen specific immunotherapy(AIT) on
small airway dysfunction in children with asthma remains unclear. The
purpose of this study is to investigate the the effectiveness of AIT on
SAD and mechanism underline with special focus on basophil.
Methods: 65 mild to moderate asthma children under regular ICS
treatment for more than one year, but their FEF
remained below the 65% of predicted and with positive results of serum
Der p or der f were enrolled. Asthma children underwent house dust mite
(HDM) subcutaneous immunotherapy (SCIT) treatment for 6 months. Asthma
control and lung function were evaluated every three months during HDM
SCIT treatment. Basophil activation test was carried out before and
after HDM SCIT treatment. RNA-sequence were performed in isolated
basophil from peripheral blood after 6 mionths of HDM SCIT treatment
followed by GO term and KEGG pathway enrichment analysis between
patients with or without HDM SCIT treatment. Results: The
patients’ childhood asthma control test(C-ACT) scores have risen above
the baseline value after 3 and 6 months’ treatment. The percentage of
patients with complete asthma control was also increased from 52.4% to
75.8% (after 3 months of AIT treatment) and 73.7% (after 6 months of
AIT treatment). Meanwhile, the percentage of uncontrolled asthmatic
patients (C-ACT score＜20) dropped from 9.52% to 3 % and 0% after 3
and 6 months’ treatment of AIT, respectively. AIT treatment also
improved lung function parameters such as FEV /FVC, FEF
, FEF and MMEF after the first 3
months’ therapy (p＜0.05). FEF values showed a highly
significant, gradual and persistent increase (from 49.55 ± 1.27% at
baseline to 65.56 ± 2.89 % and 71.89 ± 2.64 % after 3 months’ and
6months’ therapy, respectively). 24 of 32 patients were out of SAD after
6 months’ treatment. BAT results revealed that AIT treatment
significantly reduced basophil activity to HDM in vitro challenge from
baseline. GO term and KEGG pathway enrichment analysis of basophil
revealed that downregulated genes mainly involved in immune cell
activation, antigen presenting procedure and Th cell differentiation.
Conclusions: Our current study demonstrated that HDM AIT not
only improved asthma symptom and clinic parameters, but also increased
lung fuction parameters, especially improved SAD measured by FEF
, FEF and MMEF. We also
demonstrated that HDM AIT reduced basophil activity. RNA-sequence of
basophil revealed the inhibiton of phagocytosis and phagosome pathway
which is required for the APC function of basophils and therefore may
affect the polarization of Th2 cell differentiation. However, further in
vivo and animal study are required to confirm those results.
Automated Citation Searching in Systematic Review Production: A Simulation Study Protocol and Framework
Authors: Rajit Darren , Du Lan , Teede Helena , Callander Emily , Enticott Joanne
Published: July 2023

Citation mining, citation searching or snowball searches have been
recommended as a supplementary search method in the conduct of
systematic searches for evidence retrieval as part of systematic review
production. However, manual methods are extremely costly and
time-consuming, with limited empirical evidence for their utility, and
limited guidance on how best to incorporate the method during systematic
review production. Encouragingly, the advent of programmatic access to
bibliographic databases has enabled exploration of automated citation
mining for a potentially scalable and replicable approach. Thus, the
study aims to simulate and evaluate the use of exclusively automated
citation searching methods for evidence retrieval compared to reference
standard boolean logic-based methods, and to explore the factors that
influence performance. Methods: A total of 30 systematic reviews will be
retrieved from the Cochrane Database of Systematic Reviews, Campbell
Systematic Reviews and the Collaboration for Environmental Evidence
(CEE). Baseline characteristics will be extracted, including the
performance of the reference standard boolean search strategy in terms
of recall, precision and F(1-3)-score for each sample review. Seed
articles from the background and methods section of each sample review
and their baseline characteristics will then be extracted, and automated
citation searching will be conducted for different seed article and
database combinations (Semantic Scholar, OpenAlex). Each seed article
candidate will be ranked according to recall, and the top 10 seed
articles will be combined in all possible combinations and evaluated.
The end performance of automated citation searching will then be
compared against the reference standard Boolean strategy for each sample
review. The association of factors related to i) automated citation
search parameters, ii) characteristics related to review question, and
iii) characteristics related to the initial starting set of seed
articles will be evaluated. Empirical guidance surrounding the use of
automated citation searching will then be generated.
Comparison of Xrn1 and Rat1 5′→3′ exoribonucleases in budding yeast supports the unique role of Xrn1 in co-translational mRNA decay
Authors: Perez-Ortin Jose , Jordán-Pla A. , Zhang Y. , Moreno-García J. , Campos-Mata L. , Diez Juana , Pelechano V. , Garcia-Martinez Jose , Choder Mordechai
Published: July 2023

The yeast Saccharomyces cerevisiae and most eukaryotes carry two
5’→3’ exoribonuclease paralogues that are very similar. In yeast, they
are called Xrn1, which shuttles between the nucleus and cytoplasm and
executes major cytoplasmic mRNA decay, and Rat1, which carries a strong
nuclear localization sequence (NLS) and localizes in the nucleus. Xrn1
is 40% homologous to Rat1 but has an extra ~500 amino
acids C-terminal extension. In the cytoplasm, Xrn1 can degrade decapped
mRNAs during the last round of translation by ribosomes
“co-translational mRNA decay”. The division of labor between the two
enzymes is still enigmatic and can serve as a paradigm for division of
labor of many other paralogues. Here we show that Rat1 is capable of
functioning in cytoplasmic mRNA decay, provided that Rat1 remains
cytoplasmic due to its NLS disruption (cRat1). This indicates that the
actual segregation of the two paralogues plays roles in their specific
functions. However, segregation is not sufficient for fully
complementing Xrn1 function. Specifically, cRat1 can only partially
recover cell volume, mRNA stability, proliferation rate, 5’→3’ decay
alterations that characterize xrn1Δ cells. In particular,
co-translational decay is only little complemented by cRat1. Adding the
Xrn1 C-terminal domain to Rat1 does not improve the phenotypes
indicating that lack of C-terminal is not the reason for the partial
complementation. Collectively, it seems that during evolution the two
paralogues acquire unique features that make the division of work
beneficial.
Implementation of the London Measure of Unplanned Pregnancy in routine antenatal care in London: a mixed-methods evaluation
Authors: Hall Jennifer , Stewart Catherine , Stoneman Bryony , Bicknell Tamsin , Duncan Helen , Stephenson Judith , Barrett Geraldine
Published: July 2023

Objective: To evaluate the implementation of the London Measure of
Unplanned Pregnancy (LMUP) in antenatal care. Design: Mixed methods
evaluation of a pilot. Setting: Antenatal care at University College
London Hospital and Homerton Hospital, England, 2019-2022. Population:
Pregnant women attending antenatal care at one of the sites during the
evaluation. Methods: Quantitative and psychometric analysis of anonymous
data and qualitative analysis of interviews and focus groups with women
and midwives, using a Framework Analysis. Main Outcome Measures:
Acceptability of the inclusion of the LMUP, measured by completion rates
and women’s and midwives opinions. Results: Completion of the LMUP at
UCLH stabilised at around 70% and the LMUP performed as expected.
Asking the LMUP at antenatal booking appointments is feasible and
acceptable to women and midwives. Advantages of asking the LMUP,
highlighted by participants, include providing additional support and
personalising care. Midwives’ concerns about judgment were
unsubstantiated; women with unplanned pregnancies valued such
discussions. Conclusions: These findings support the implementation of
the LMUP in routine antenatal care and show how it can provide valuable
insights into the circumstances of women’s pregnancies. This can be used
to help midwives personalise care, and potentially reduce adverse
outcomes and subsequent unplanned pregnancy. Integration of the LMUP
into the Maternity Services Data Set, will establish national data
collection for a population-level measure of unplanned pregnancy,
serving as a key outcome measure for sexual and reproductive health and
enabling analysis of the prevalence, factors, and implications of
unplanned pregnancies across subpopulations to inform implementation.
Funding : NIHR PDF-2017-10-021
Jak uczynić płeć piękną? Środki pielęgnacyjne według Marcina z Urzędowa
Authors: Suchecka Anna
Published: July 2023

Artykuł dotyczy środków pielęgnacyjnych opisanych przez Marcina z Urzędowa w Herbarzu polskim z 1595 r. Składa się on z opisów 549 gatunków roślin oraz środków leczniczych pochodzenia mineralnego i zwierzęcego. Analiza jego treści pozwoliła na identyfikację 68 opisów zawierających porady w zakresie dbania o higienę ciała, a zwłaszcza twarzy. Zostały one usystematyzowane pod względem dolegliwości i potrzeb pielęgnacyjnych, wśród których najważniejsze dotyczą rozjaśnienia skóry, pozbywania się piegów, zmarszczek, blizn, opalenizny oraz barwienia włosów i brwi, a także upiększenia twarzy. Umożliwiło to rozpoznanie wyznawanego przez Marcina ideału piękna i zarysowanie inspiracji kulturowych autora sięgających do wzorców estetycznych obowiązujących wśród elit włoskiego renesansu.
DIGITESAUDE.PT – Portugal, Envelhecimento e Saúde: o impacto da transição digital na atualidade e os desafios do futuro
Authors: Rodrigues Teresa , Estevens João
Published: July 2023

COVID-19 created an environment that accelerated the applications of digital technology in all domains. In health care, governments and institutions needed quick responses to mitigate the impacts of the pandemic and the digitization of health care is part of that response. The growing digitization of health care generates opportunities in response and economic efficiency, but also with challenges related to widespread access to health care. Difficulties intensify when we talk about the elderly, who tend to have average levels of digital literacy below the national average, but who cannot be forgotten in the current process of digital transition, particularly in an area such as health care.
Effects of holy basil (Ocimum sanctum) on viral disease of chili (Capsicum annum L.) under mixed crop cultivation
Authors: Arsi Arsi , SHK Suparman , Lailaturrahmi  , Hamidson Harman , Pujiastuti Yulia , Umayah Abu , Gunawan Bambang , Pratama Rahmat , Irsan Chandra , Suwandi
Published: July 2023

Chili is one of the important commodities in Indonesia. Chili cultivation faces many obstacles, leading to a decrease in production, such as virus infections. Yellow leaf curl and curly top viruses are groups of viruses that are often found in chili fields. This research was conducted to investigate the effect of intercropping (basil-chili) in suppressing viral diseases, especially yellow leaf curl and curly top viruses. A Randomized block design was used for this research, including intercropping and monoculture. The parameters observed in this study included disease incidence and intensity, the number and weight of chilies. Symptoms of virus infection include leaf curl, yellowing, and stunting. The disease has been reported to be transmitted by insect vectors, such as Aphis gossypii and Bemisia tabaci. The results showed that the incidence and intensity of yellow leaf curl and curly top virus diseases in chili pepper and basil plants were not significantly different in each treatment. The number of healthy chilies and their weight were also not significantly different. Damaged chilies are fruits that have been attacked by fruit flies. Basil intercropped with chilies attracts fruit flies, which affects the quantity and weight of the harvested chilies. The population of B. tabaci was significantly different in each treatment, while A. gossypii did not show significant differences among the treatments. Intercropping basil and chili increased the population of A. gossypii, while the population of B. tabaci decreased in this treatment. These two insect pests are vectors for yellow leaf curl and curly top viruses.
Mapping the Dimensions of Linguistic Distance: A Study on Quantitative and Qualitative Geolinguistics of Banjar Sundanese Dialect
Authors: Wagiati  , Darmayanti Nani , Yohanarisagarniwa Yuyu , Zein Duddy
Published: July 2023

The study was motivated by the factual condition of methodological and theoretical deficiencies promoting the mapping and classification studies of Sudanese Dialect.  The study aims to investigate (1) the comprehensive regional classification of Banjar Sundanese Dialect and (2) the linguistic and non-linguistic factor identification supporting the regional distance in the classification of Banjar Sundanese Dialect. In this case, the study applied a combination method (mixed research methods). The data were collected through participant observation. Furthermore, the calculation of Banjar Sundanese Dialect linguistic distance employed the Levenshtein algorithm in Gabmap. Multidimensional scaling was used to ensure the reliability of the clustering results. Based on the calculation results of the linguistic distance, Banjar Sundanese Dialect can be classified into three sub-dialects, namely the standard Sundanese sub-dialect; the Java-influenced sub-dialect; and the Java-dominated sub-dialect. The study reveals that there are significant differences between Banjar Sundanese Dialect, especially Purwaharja and Langensari sub-dialects, and Standard Sundanese Dialect. One of these differences is caused by the influence of the Javanese language.
E-Modul Flipbook sebagai Sumber Pembelajaran Akuntansi pada Sekolah Menengah Kejuruan
Authors: Julaeha Siti , Herawan Endang , Anisah Aan
Published: July 2023

This research aims to as produce a design for teaching materials of the type of e-module in the form of a flipbook. The approach in this study is a qualitative approach with a design-based research (DBR) method. This research produces flipbook e-module teaching materials made using a corporate flip PDF application that can be accessed on the web on various devices. Based on the validation results, this flipbook e-module is categorized as very feasible with an average overall score of the three is 3,81 so that this flipbook e-module is suitable for use as teaching materials in vocational high schools.
Penguatan Anti Fraud Awareness Mahasiswa melalui Pembelajaran Pengantar Akuntansi 1 Berbasis Problem Based Learning Models Through Contextual Approach
Authors: Rahmi Elvi , Friyatmi Friyatmi , Siwi Menik Kurnia , Takidah Erika , Syahrul Syahrul , Oksefa Primayaora , Hidayat M Topit
Published: July 2023

Good character and awareness are things that are very much needed in carrying out work in various kinds of student professions as future leaders need to have anti-fraud awareness so that later it is hoped that Indonesia will be more honest and clean. Learning. This study aims to increase student fraud awareness through accounting learning using Problem Based Learning Models Through Constextual Approach. This research is a Classroom Action Research study which has a spiral model from Kemmis and Toggart. The research procedure consists of several activity cycles. Which includes the stages of planning (plan), action (act), observation (observe) and reflection (reflection). The data collection instrument consisted of observation sheets, field notes and questionnaires. Data were analyzed using a quantitative descriptive approach using percentages. The results showed that after carrying out 2 cycles of PTK in accounting learning 1, fraud awareness of students was in the very good category with a total score of 90.8
Penggunaan Maure Sipema (Media Augmented Reality – Inovasi Pembelajaran Akuntansi Mahasiswa) dalam Meningkatkan Motivasi dan Prestasi Belajar
Authors: Cerya Efni , Syamwil Syamwil , Marwan Marwan , Narmaditya Bagus Shandy , Agustian Viky , Maulidina Yuriza , Susanti Ria , Yani Rahma
Published: July 2023

This study aims to determine the improvement in student motivation and performance by applying Maure Sipema (Media Augmented Reality - Student Accounting Learning Innovation) to the accounting materials of a manufacturing company. In this study, we employed a classroom action research (CAR) method using the four-stage Kurt Lewin model. These steps consist of planning. action; observation and reflection; My research theme is students in the first course of accounting. Test and non-test were used for data collection. The testing methodology consists of a written test at the beginning and end of each learning cycle. On the other hand, non-test techniques in the form of observational techniques, interviews and documentation during research. The analysis was based on the N-Gain-Score evaluation and was written in a qualitative descriptive format. The study was performed in 2 cycles of 5 segments. Based on Cycle I result, 72% of students completed the Maure Sipema action. Meanwhile, in Cycle II, 81% of students completed and passed the test. An open-ended questionnaire given to the students also indicated that they were more interested in participating in the lectures and more challenged to use Maure Sipema. These results highlighted the importance of innovation in learning by taking into account technological updates while also considering media compatibility with the nature of the material delivered