bluuebunny/crossref_metadata_2025 huggingface dataset:
Statistical Analysis of Gene Variants for Homologous Recombination Pathways of DNA Repair leading to Cancer Susceptibility
Authors: Adiga Usha , Jyoti B. , Reddemma P. , Augustine Alfred J. , Vasishta Sampara
Published: December 2024

Background: RAD51C, a critical member of the RAD51 paralog family, is essential for homologous recombination (HR)-mediated DNA repair, a pathway crucial for maintaining genomic stability. Mutations in RAD51C have been linked to cancer susceptibility, particularly in breast and ovarian cancers, where impaired DNA repair mechanisms contribute to genomic instability and tumor progression. Despite its clinical significance, the functional impact of specific RAD51C variants remains poorly understood, necessitating a comprehensive investigation into their biological implications.
Methods: This study classified RAD51C gene variants into damaging and tolerant categories using computational prediction tools, including SIFT, PolyPhen, CADD, MetaLR, and Mutation Assessor. Variants were prioritized based on consensus scores and classified as high-confidence damaging variants. Correlation and agreement among tools were analyzed to refine predictions. Principal Component Analysis (PCA) and clustering methods were employed to group variants based on prediction patterns. Protein-protein interaction (PPI) networks and pathway enrichment analyses were conducted to contextualize damaging variants within broader biological systems, with a focus on their roles in HR, DNA repair, and cellular processes.
Results: A total of 2526 variants were analyzed, with damaging variants showing consistent patterns across tools. Consensus scores highlighted 302 high-confidence damaging variants, which were associated with disrupted biological processes, including double-strand break repair via homologous recombination, telomere maintenance, and regulation of cell cycle checkpoints. PPI analysis revealed an interconnected network with 11 nodes and 54 edges, with a clustering coefficient of 0.982, indicating tightly coordinated interactions among DNA repair proteins. Pathway enrichment analyses identified significant associations with homologous recombination (FDR = 2.55E-17) and the Fanconi anemia pathway (FDR = 2.96E-06).
Conclusion: This study provides a comprehensive framework for assessing the functional impacts of RAD51C variants by integrating computational predictions with biological analyses. The findings underscore the importance of RAD51C in HR and DNA repair pathways, offering insights into its role in genomic stability and cancer progression. These results can inform the prioritization of variants for experimental validation and guide therapeutic strategies targeting DNA repair deficiencies.
Biostatistical Analysis of Microarray Data to Decipher Viral Pathogenesis
Authors: Adiga Usha , Kishore Banubadi Anil , Ramesh B. Venkat , Augustine Alfred J. , Vasishta Sampara
Published: December 2024

Background: Zika virus, Kunjin virus, Yellow Fever virus, & Sindbis virus belong to Flaviviridae family and are involved in derailing various biological pathways which are not yet elucidated.
Aim: Understanding the gene as well as miRNA interplay which plays a vital role in pathogenesis in the diagnosis and prognosis of the disease is of utmost significance.
Materials and Methods: By leveraging microarray data from the Gene Expression Omnibus GSE232504 dataset, we meticulously examined the differentially expressed genes & micro RNAs (miRNAs) induced by viral infections.
Results: Our analysis revealed 60 statistically significant and differentially expressed genes (DEGs) out of a total of 18,725, with SESN2 (SESTRIN 2) and GADD45A (Growth Arrest and DNA Damage-Inducible Alpha) standing out as highly significant players in the host cell response to these viruses. hsa-miR-148b-3p, hsa-miR-148a-3p, hsa-miR-607 & hsa-miR-5582-3p were the highly expressed micro RNAs (miRNAs). Through functional enrichment analyses, we unveiled significant pathways, including Type 1 Diabetes Mellitus and NF-kappa B Signaling, shedding light on the potential mechanisms underlying these virus-host cell interactions. Furthermore, our PPI (protein-protein interaction) network analysis highlighted key hub genes, while our exploration of miRNA-gene targeting relationships offered valuable insights into post-transcriptional regulation.
Conclusion: This study provides a robust foundation for understanding the molecular intricacies of virus-host cell interactions, offering potential targets for further experimental validation and paving the way for innovative therapeutic approaches in combatting viral infections and associated diseases.
Statistical Analysis of Microarray Data to Identify Key Gene Expression Patterns in Primary Hyperoxaluria
Authors: Adiga Usha , Kishore Banubadi Anil , Supriya P. , Augustine Alfred J. , Vasishta Sampara
Published: December 2024

This study aims to utilize microarray data deposited by Romero et al. and conduct bioinformatic analysis for identifying differentially expressed genes (DEGs) associated with a novel method involving gene correction at the Alanine–Glyoxylate Aminotransferase (AGXT) locus and direct conversion of fibroblasts from primary hyperoxaluria type 1 (PH1) patients into healthy induced hepatocytes (iHeps) using Clustered Regularly Interspaced Short Palindromic Repeats - CRISPR-associated protein 9 (CRISPR-Cas9) technology. Additionally, the study aims to elucidate the molecular mechanisms underlying hyperoxaluria compared to oxalate crystal formation. Romero et al.'s GSE226019 microarray data was retrieved from Gene Expression Omnibus. Statistical analysis was done in R and Bioconductor, utilizing rigorous methods to ensure robust and reproducible results. The limma program compared gene expression levels across groups. Pathway analysis, protein-protein interaction (PPI) network creation, and miRNA-target interaction network analysis were constructed. The top ten DEGs included ANGPTL3, SLC38A3, KNG1, BDH1, GC, ADH1C, ARG1, CYP3A4, AMBP, and CYP2C9. Enrichment analysis revealed significant associations with various biological pathways, including Linoleic acid metabolism and Retinol metabolism. Volcano plots and mean difference plots highlighted significant gene expression changes between different sample groups. Protein-protein interaction networks and miRNA-target interaction networks provided insights into molecular interactions and regulatory mechanisms. The top ten differentially expressed genes include ANGPTL3, SLC38A3, KNG1, BDH1, GC, ADH1C, ARG1, CYP3A4, AMBP, and CYP2C9—emerge as key players with strong associations to critical biological pathways like Linoleic acid metabolism and drug metabolism-cytochrome P450. Understanding the regulatory role of specific miRNAs (hsa-miR-4501, hsa-miR-5692c, hsa-miR-6731-3p, hsa-miR-6867-5p, hsa-miR-616-3p, hsa-miR-4468, hsa-miR-3692-3p, hsa-miR-4277, hsa-miR-4763-5p, hsa-miR-4797-5p) in gene expression could provide further insights into disease mechanisms and potential therapeutic avenues. The statistical findings provide a foundation for predictive modeling, hypothesis testing, and exploring personalized therapeutic strategies.
Operasi Plastik dalam Islam: Tinjauan tentang Kebutuhan, Prinsip Syariah, dan Pertimbangan Etis
Authors: Naila Azzahra  , Azkia Zahra Safa  , Luthfina Noor Afrila
Published: December 2024

This research examines the practice of plastic surgery from the perspective of Islamic law, which is increasingly relevant in the modern era with increasing aesthetic demands. Plastic surgery is divided into two types: reconstructive, which is permitted for medical purposes, and aesthetic, which is generally prohibited if not supported by clear medical reasons. This study is based on the principles of maslahah and madlorot, as well as the ijtihad of the ulama, which shows that medical procedures are permissible if they bring benefits and avoid harm. This research also highlights the challenges Muslims face due to unrealistic beauty standards, especially on social media, which often conflict with religious values. The research results show the importance of religious education that emphasizes self-acceptance and building a community that supports diversity in appearance. Suggestions for ethical medical practice in plastic surgery are also proposed, so that the procedure is in line with Islamic principles. In this way, it is hoped that Muslims can navigate modern demands without sacrificing religious values.
Relevansi Filsafat Pendidikan Islam dengan Tantangan Globalisasi dalam Pembentukan Karakter Muslim
Authors: Syuhadatul Husna  , Nurul Hikmah  , Herlini Puspika Sari
Published: December 2024

Islamic Education Philosophy has been a solid foundation in shaping Muslim character for centuries. However, in the dynamic and challenging era of globalization, the relevance of this philosophy is increasingly questionable. This study aims to analyze the extent to which the principles of Islamic Education Philosophy are still relevant in shaping Muslim character that is able to face the complexities of the modern world. Through literature review and comparative analysis, this study reveals that the core values of Islamic Education Philosophy such as monotheism, akhlakul karimah, and knowledge are still very relevant in shaping Muslim character that is faithful, has noble character, and has global competence. This study also identifies specific challenges faced by Islamic education in the era of globalization, as well as strategies that can be applied to overcome these challenges. The results of this study are expected to contribute to the development of a more relevant and effective Islamic education curriculum in shaping a quality Muslim generation.
Pengaruh Penerapan Model Active Learning Tipe Everyone is A Teacher Here terhadap Keaktifan Belajar Pendidikan Agama Islam Siswa di SMP N 1 Panti Kabupaten Pasaman
Authors: Febi Muliani  , Arifmiboy Arifmiboy  , Iswantir M  , Charles Charles
Published: December 2024

This research was conducted because researchers saw that PAI teachere still appilied conventional learning models during the Islamic religious education learning process. Researchers saw that many students did not play an active role during the question and answer session, and lacked the courage to express their opinions. during the learning process. The purpose of conducting this research is to find out whether there is an influence of implementing the Everyone Is Teacher Herr Active Learning Model on students' active learning in Islamic religious education at SMP N 1 Panti, Pasaman Regency. The type of research used by researchers is quasi-experimental research. The population of this research is all class VIII students, totaling 129 students. The technique used in sampling by researchers was odd semester UTS scores and then a normality test and homogeneity test were carried out and the samples were determined randomly. Data collection was carried out by researchers using a questionnaire, the analysis technique was carried out using the f-test and t-test. The results of the analysis using the f test in the experimental class had a value of 4.701 with a significance level of 0.040-0.005 so it could be concluded that there was an influence, while the results of the analysis using the t in the control class there is a t-hit value of 4.357> t-table 2.064 and a significance level of 0.000 0.05 and it can be concluded that there is differences in student activity.
Peran Orang Tua dalam Membina Akhlak bagi Anak dalam Lingkungan Keluarga di Jorong Balai Panjang Nagari Saniang Baka
Authors: Muhammad Rusdi  , Muhiddinur Kamal  , Salmi Wati  , Wedra Aprison
Published: December 2024

We sought to investigate how families in Jorong Balai Panjang Nagari Saniang Baka, X Koto Singkarak District, Solok Regency, teach moral principles to their children. The author is interested in studying the role of parents in developing morals in children in the family environment at Jorong Balai Panjang Nagari Saniang Baka because they want to know about the younger generation who reflect superior ethics (morals). This research highlights several aspects of the depth of information collected from interviews and uses qualitative methods supported by field observation techniques. In District The leader or head of the jorong and friends act as informants to support the research. According to research, parents have a significant influence on the development of their children's moral principles (morals). This research highlights the important role of parents in shaping children's moral character in the family context. Parents play a number of roles, including modeling appropriate language and accent when speaking to their children, influencing their behavior and relationships, being role models and motivators, and teaching their children about religion. If these roles are fulfilled, it is likely that the offspring will have good morals. There are many things that are difficult for parents to regulate regarding children's behavior, such as contact with people outside the household, cell phone use, and the games they play. All of these obstacles lie within the child himself. If the child is willing to change and is willing to listen to the words of advice from his parents then these obstacles can be overcome.
Kompetensi Kepribadian Diri Guru di Pesantren
Authors: Bagas Nirwana Selian  , Ainal Mardhiah
Published: December 2024

This research aims to analyze the personality competencies of teachers in Islamic boarding schools. The research method used is descriptive qualitative, data collection is carried out through observation, questionnaires and documentation. The research results show that teachers at the Sulaymaniah Blang Bintang Islamic Boarding School have good personality competencies, which are reflected in their attitudes, values ​​and behavior. A positive attitude, integrity and teacher example are important elements in creating a conducive learning environment. Apart from that, the teacher's ability to communicate and manage emotions also contributes to harmonious interactions with students. This research confirms that teacher personality competencies not only influence the quality of teaching, but also play an important role in forming the character of students, so it is important for educational institutions to continue to support the development of these competencies through training and professional development programs.
Prinsip Muamalah dalam Ekonomi Syariah: Tinjauan dan Implementasi
Authors: Rodia Rotani Rianda  , Bella Anggraini  , Sarah Dalila Fitri  , Wismanto Wismanto
Published: December 2024

This journal discusses the principles of muamalah in the context of sharia economics, with the aim of understanding how these values ​​are implemented in daily practice. This research uses a qualitative approach with interviews and literature study as the main methods. The research results show that sharia-compliant muamalah not only contributes to economic sustainability, but also improves social justice. It is hoped that this article will provide insight for economic actors and academics in understanding and applying the muamalah principle.
Efektivitas Dakwah Digital dalam Meningkatkan Keberagaman Mahasiswa
Authors: Isak Iskandar  , Safitri Nur Fadila  , Pitaloka Pitaloka  , Agung Juansyah
Published: December 2024

In today's digital era, social media, especially Instagram, has become the main platform for spreading information and messages, including da'wah. Students as the young generation who actively use social media have great potential to receive and spread da'wah messages. This study examines the extent to which da'wah delivered through Instagram can influence students' understanding of diversity, both in terms of ethnicity, culture, religion, and other perspectives. The method used is a survey by distributing questionnaires to students from various universities. The results of the study indicate that da'wah on Instagram has a positive influence in increasing students' awareness and understanding of the importance of diversity, as well as encouraging an attitude of tolerance and mutual respect. However, the effectiveness of this da'wah is influenced by the quality of the content, consistency of delivery, and audience involvement. This study concludes that Instagram da'wah can be an effective tool for promoting diversity values ​​among students, with the note that there is an appropriate strategy in delivering da'wah messages
Peran Remaja Masjid dalam Meningkatkan Partisipasi Keagamaan Peserta Didik di SMP Negeri 19 Surabaya
Authors: Dwi Wulandari  , Muhammad Fahmi  , Fathur Rohman
Published: December 2024

This study aims to analyze the role of Teen Mosque (Remas) in increasing students' religious participation in SMP Negeri 19 Surabaya. Through structured daily, weekly, and annual religious programs, mosque teenagers play an important role in instilling religious values to students. Programs such as morning tadarus, duha prayer, dhuhur prayer, as well as weekly rohis and PHBI activities become a forum for spiritual development for students. In addition, collaboration between Remas, teachers, student council, and external institutions also supports the effective implementation of activities. The research method used is qualitative with a case study approach. Data were collected through in-depth interviews with religion teachers, youth mosque coaches, students, and participatory observation of religious activities at school. The analysis was conducted by describing and interpreting the role of Remas in encouraging students' participation in religious activities. The results showed that the role of mosque teenagers is very significant in increasing students' religious participation, making SMP Negeri 19 Surabaya a school with a strong spiritual atmosphere. Although there are challenges such as the lack of religious awareness among students. The existence of mosque teenagers helps create a religious school environment, so that SMP Negeri 19 Surabaya can be an example in fostering students' spirituality in the environment.
Analisis Fashal Dalam Q.S. Al-Mulk Ayat 19 Studi Tentang Kekuasaan Allah
Authors: Fadwa Nabilah  , Bunayya Zean Fathir  , Nursumayyah Damanik
Published: December 2024

Not everyone is able to understand the messages in the Al-Quran. So in an effort to understand it, fashal is an important part that must be studied to avoid confusion in the meaning of the verses of the Koran that are addressed to humans. Fashal is usually used to separate sentences that have various forms. The aim of this research is to describe the meaning of fashal, explain the division of various types of fashal and the function of fashal, and analyze the form of fashal in Q.S Al-Mulk verse 19. The method used in this research is a qualitative method with a library research approach. The data sources used in this research include primary and secondary data sources originating from books and journals as a relevant basis. The analysis used in this research is descriptive analysis which provides a broader explanation and is in a form that is easy to understand.
Analisis Komparatif Konsep dan Metode Pendidikan Islam untuk Anak dalam Perspektif Syekh Nawawi Al-Bantani dan Abdullah Nashih 'Ulwan
Authors: Kamila Rahma Shalehah  , Salsabila Salsabila  , Anggi Kurniawan  , Syarifah Alawiyah  , Abdul Fadhil
Published: December 2024

This research is motivated by the rampant moral decadence that needs attention. Underlining the responsibility of parents and educators in educating children, including the importance of the right method to shape children's faith, morals, knowledge, mentality, and social. Sheikh Nawawi Al Bantani and Abdullah Nashih 'Ulwan were appointed as the main focus because of their influential thoughts in the context of children's education. The purpose of this study is to describe, compare, and analyze the relevance of the thoughts of the two figures regarding children's education in the context of contemporary Islamic education. This study uses a Qualitative Descriptive-Analytical approach with a literature review nature. The data obtained are sourced from primary data as the main reference obtained from a book entitled Tarbiyatul Aulad Fil Islam by Dr. Abdullah Nashih 'Ulwan and the book Tanqih Al-Qaul by Sheikh Nawawi Al-Bantani. While secondary data is obtained from journals, expert books, and previous scientific articles. Descriptive in explaining the arguments and comparison of the two concepts and methods, analysis to describe the contents in depth. In this study it was found that the educational methods proposed by Sheikh Nawawi al-Bantani and Abdullah Nashih have similarities even though the approaches and implementations are different, both discuss Islamic education that prioritizes noble morals which are very relevant considering the contemporary era which is full of moral crises.
Perbandingan Sistem Pendidikan di Jepang dengan Indonesia
Authors: Sarmila Sarmila  , Mislaini Mislaini  , Liza Amelia
Published: December 2024

The education systems in Japan and Indonesia have significant differences in structure, philosophy and educational practices. Japan is known for its highly structured education system, high discipline, and an emphasis on academic excellence and hard work. The education system in Indonesia and in Japan has its own advantages and disadvantages. Currently, the education system in Indonesia needs more attention because it is ranked 72 out of 77 countries. In Indonesia, many educational experts have been born who are able to bring the education system in Indonesia to a better direction. One way to bring Indonesia's education system to a better direction is to compare it with a country with a good education system like Japan. In Japan, from the age of 0-4 years, children are more instilled with moral values, manners and discipline. When children in Japan have entered the 4th grade of elementary school, these children take exams that are not too burdensome for students at school. Indonesia can learn a lot with the education system in Japan.
Sejarah Perkembangan Sistem Pendidikan Di Filipina
Authors: Syarifah Rahmayani  , Mislaini Mislaini  , Oktaviana Imroatun Cahyati
Published: December 2024

The history of the development of the education system in the Philippines, which reflects the nation's long journey through various cultural influences and colonialism. Starting from the informal education that existed in pre-colonial societies, this article outlines the significant changes that occurred with the arrival of Spanish colonialists in the 16th century, who introduced a formal education system with a focus on Catholic teachings. Furthermore, the transition to a modern education system occurred under American colonial rule in the early 20th century, where English was introduced as the language of instruction and democratic values were promoted. This article also explores the challenges facing the Philippine education system post-independence, including efforts to create inclusive and relevant education. With an in-depth analysis of these various phases of development, this article aims to provide a better understanding of the dynamics of education in the Philippines and its impact on society today.
Pengaruh Teknologi Membangun Budaya Organisasi : Penggunaan Fingerprint dan Aplikasi Presensi di Pondok Pesantren Darul Arifin Jambi
Authors: Andi Zainal Abidin  , Muhammad Taraki  , Lidin Wiwah Jaya Putra  , Jamrizal Jamrizal  , Samsu Samsu
Published: December 2024

Technology plays an important role in organizational culture if managed well and is very helpful in the rotation of an organization's journey. Finger print, for example, is a technological tool that contributes to building organizational culture. This tool not only functions as an attendance system, but also creates time discipline, transparency, and accountability among team members. Technology implementations like these demonstrate how technology can be used to support an organization's core values. Apart from that, applications such as E Pesantren Presence also provide digital solutions for monitoring attendance in real-time, which is very helpful for based organizations. Of course, the Head of Human Resources really feels helped by the contribution of technology in achieving organizational goals and it is very beneficial for teachers to have a disciplined character to apply and set an example for the students.
Peningkatan Kecerdasan Spiritual Guru Melalui Kegiatan Morning Spiritual Gathering di Pesantren Darul Ilmi
Authors: Luthfi Anis Muadzin
Published: December 2024

This research aims to decrypt the implementation of Morning Spiritual Gathering (MSG) activities as an effort to increase the spiritual intelligence (SQ) of teachers at the Darul Ilmi Muhammadiyah Tarakan Islamic Boarding School. This study uses a qualitative approach with data collection techniques through observation, interviews, and documents. The results of the study show that the Morning Spiritual Gathering has a positive impact on improving the quality of teaching and interaction between teachers and students, as well as strengthening Islamic ukhuwah between teachers. In addition, this activity also increases teachers' sense of responsibility, patience, and empathy in teaching. MSG encourages teachers' self-reflection and creates a more Islamic environment, supporting the development of students' character. Some teachers proposed a variety of learning methods to increase participant engagement. Overall, MSG activities contribute to improving teachers' spiritual intelligence and a more conducive learning atmosphere in Islamic boarding schools.
Pembelajaran PAI Berbasis Canva untuk Meningkatkan Minat Belajar Siswa di SMA Muhammadiyah 3 Jember
Authors: Nur Dzaedzatul H  , Khozin Khozin
Published: December 2024

This research aims to describe the implications of using Canva media in increasing students' interest in learning in class X in the subject of using Canva media in increasing the learning motivation of class This research uses a qualitative approach using the case study method, which provides descriptive data about the reality in the field using observation, interviews and documentation instruments. The research subjects were class X students at SMA Muhammadiyah 3 Jember. The object is the PAI teacher at SMA Muhammadiyah 3 Jember. The use of Visual Learning Media Based on the Canva Application makes children more active and enthusiastic in learning, because the appearance of Canva media is attractive, the images and colors are appropriate and attracts children's interest in learning which is supported by children's curiosity about this visual media is very high, so that children don't get bored of learning. So it can be concluded that the research results are expected to show that the use of Canva-based learning media can increase students' interest in learning. in PAI subjects."
Overview Of Nursing Care Implementation Critical in The Emergency Room Of Santa Elisabeth Hospital Medan
Authors: Brigitta Cahyani Silva Kristiani Waruwu  , Mestiana Br. Karo  , Mardiati Barus
Published: December 2024

A Critical nursing care is a process for problem solving, decision making as well as an organized and systematic approach to nursing problems. Nursing care must be carried out completely and accurately because it is the nurse's self-defense against demands as well as proof that the correct nursing care has been carried out. The research objective is to find out the description of the implementation of critical nursing care in Emergency Room of Santa Elisabeth Hospital Medan 2023. The research design used is a descriptive research design. There are two populations in this study, namely nursing actions and documentation of critical nursing care, the sampling technique used purposive sampling 51 respondents and total sampling (critical nursing care documentation) as many as 68 respondents. The data collection instrument uses observation sheets for nursing actions consisting of infusions, ECG usage and oxygen therapy, as well as critical nursing care using observation sheets consisting of assessment, diagnosis, intervention/implementation and evaluation. The results show that the infusion was according to the SOP, the use of ECG was according to the SOP and sufficient oxygen therapy is according to the SOP for 51 respondents (100%). Critical nursing care complete review 65 (96%), diagnosis quite complete 48 (71%), complete intervention/implementation 65 (96%), complete evaluation 67 (99%) and documentation of critical nursing care majority complete 65 (96%) of 68 respondents. It is expected to be able to improve the accuracy and completeness of nursing care documentation through training for each officer.
Changes in brain functional connectivity of patients with postoperative delirium
Authors: Deng Tuo , Tan Changkuan , Ma Guangkuo , Zhou Meiyan , Wang Liwei
Published: December 2024

Postoperative delirium (POD) is an acute cognitive disorder marked by attention deficits, fluctuating symptoms, and significant cognitive impairment. These features are closely associated with adverse outcomes, including increased mortality, prolonged hospitalization, long-term cognitive deficits, and elevated healthcare costs. Brain functional connectivity studies focus on understanding complex neuronal interactions and interregional communication within the brain. This article explores the association between POD and brain functional connectivity. It begins by summarizing the prominent features of POD as a common postoperative complication and its substantial impact on patient health, highlighting current limitations in understanding the pathophysiological mechanisms. The article then investigates the relationship between functional connectivity and cognitive function, emphasizing the role of advanced monitoring techniques, including Electroencephalography and Functional Magnetic Resonance Imaging. The advantages and limitations of these technologies in studying brain connectivity are discussed. Additionally, the article focuses on the posterior cingulate cortex and Default Mode Network, examining their roles in the development of POD and their potential connections to its pathogenesis. Finally, the application of graph theory in connectivity analysis is introduced, offering new insights into POD’s pathogenesis. Based on current evidence, the article provides an outlook on future research directions and potential challenges. This study particularly emphasizes the impact of perioperative factors, such as anesthesia and postoperative inflammation, on brain functional connectivity. These changes may trigger POD by disrupting connectivity within the Default Mode Network and other key neural networks. By investigating the changes in brain functional connectivity patterns in patients undergoing different types of surgeries, this study further reveals the contribution of perioperative factors to the pathophysiological mechanisms of POD.
Kaffâl eş-Şâşî’nin Hadisçiliği
Authors: Küçükosman Hasan
Published: December 2024

Yaşadığı dönemde en çok rıhle yapan kimse olarak bilinen Kaffâl eş-Şâşî; Taberî, Begavî, İbn Huzeyme, gibi otoritelerden hadis dinlemiştir. Özellikle döneminin muhaddisi, İmam Tirmizî’nin Sünen’i ve Şemâil’ini rivayet eden icazetli talebesi Heysem b. Küleyb kanalıyla İmam Tirmizî’nin rivayetlerine ulaşmıştır. eş-Şâşî’nin makâsıd düşüncesini ortaya koyduğu eseri Mehâsinü’ş-şerîʿa’da âyet ve hadislere daha az başvurduğu görülmektedir. Bu sebeple rivayetlerin senedinden ziyade manasına önem veren Kaffâl eş-Şâşî, şer’î hükümlerin hikmetlerini incelerken örf ve sünnet ilişkisinden bahsetmiştir. Burada Hz. Peygamber’in söz ve fiillerin bağlayıcılığı, maslahat, istihsan gibi meselelerde düşünceleri ile sünnete bakışı tespit edilebilmektedir. eş-Şâşî’nin teknik bağlamda hadisçiliği daha çok Şemâʾilü’n-nübüvve adlı eserinde görülmektedir. Pek çok rivayeti senedleriyle birlikte zikreden Kaffâl eş-Şâşî’nin buradaki hocalarına baktığımızda Mâverâünnehir’in muhaddisi olarak bilinen Ömer b. Muhammed b. Büceyr gibi muhaddis lakaplı pek çok hoca bulunmaktadır. Kendisinden nakledilen rivayetlere baktığımızda ise bazı tarih ve tefsir kaynaklarında surelerin fazileti ya da İsrâiliyat ile ilgili haberler bulunmaktadır. Bu rivayetler sened ve metin açısından sorunlu görülmektedir. eş-Şâşî’nin özellikle î‘tizâl düşüncesine sahip olması ile itham edilmesi sonucunda yeterli ilgiyi görememiş ve hem rivayetleri hem de eserleri üzerinden bir çalışma yapılmamıştır. Halbuki Hanefîlerin etkin olduğu bir yer olan Şâş bölgesinde Şâfîlik düşüncesini yaygınlaştıran birisi olması dahi kendisinin ne derece etkili bir âlim olduğunu göstermektedir.
Prevalencia de ansiedad y depresión en mujeres con menopausia
Authors: Espitia de la Hoz Franklin José
Published: December 2024

Objetivos. Describir la prevalencia de ansiedad y depresión en mujeres en menopausia, así como los factores asociados. Material y métodos. Estudio transversal; se incluyeron mujeres en menopausia, atendidas en la unidad de climaterio/menopausia en dos clínicas privadas de referencia, ubicadas en Armenia y Pereira, Colombia. Realizado entre 2022 y 2023. Se midieron variables sociodemográficas y clínicas. Se estimó la frecuencia de ansiedad y depresión. Se aplicó la Escala de depresión de Beck, la Escala de Hamilton para la ansiedad y la Escala de clasificación de la menopausia para los síntomas menopáusicos. Se utilizó el software SPSS 24® para el procesamiento y análisis estadístico. Resultados. Se incluyeron 249 participantes, con edad promedio de 53,79 ± 8,62 años (inferior 45 y superior 67). La prevalencia de ansiedad fue de 33,73%, y la de depresión, de 30,12%. La depresión en la menopausia está asociada con no tener pareja (OR: 5,44; IC del 95%: 3,0-9,9); obesidad (OR: 4,23; IC del 95%: 2,4-7,5) y tabaquismo (OR: 4,2; IC del 95%: 2,0-8,7). Como factor protector se encontró la terapia hormonal de la menopausia (OR: 0,26; IC del 95%: 0,1-0,6) y la actividad física (OR: 0,32; IC del 95%: 0,2-0,5). Conclusiones. La prevalencia de ansiedad y depresión en mujeres en menopausia alcanza 1/3 de la población, las más afectadas son las mujeres sin pareja, con obesidad y fumadoras. Se requieren intervenciones donde se atiendan los trastornos de salud mental que se presentan durante la menopausia.
Estudio de cohorte sobre el riesgo cardiovascular en una unidad oncológica de un hospital latinoamericano
Authors: Dulcey Sarmiento Luis Andrés , Therán León Juan Sebastián , Cabrera Peña Valentina , Parales Strauch Rafael Guillermo , Blanco Pimiento Edgar Camilo
Published: December 2024

Introducción. Desafortunadamente, las complicaciones cardiovasculares (CV) de las terapias contra el cáncer pueden afectar los resultados del tratamiento. El objetivo del estudio fue evaluar la prevalencia de los factores de riesgo CV clásicos en los pacientes con nuevo diagnóstico de cáncer y, por lo tanto, identificar el riesgo CV. Métodos. Los conjuntos de datos de diagnóstico de electrocardiograma en reposo, muestras de sangre y ecocardiograma transtorácico se analizaron en 343 pacientes consecutivos sin ninguna enfermedad CV que pudiera afectar el tratamiento introducido. Resultados. Nuestra cohorte incluyó 4,4% de pacientes con cáncer de riñón, 7,3% con cáncer colorrectal, 26,5% con neoplasias malignas hematológicas (NMH) y 61,8% con cáncer de mama. El riesgo estimado por SCORE fue de 4,56 ± 5,07%. Los pacientes con cáncer de mama tenían menor riesgo CV que aquellos con NMH (p = 0,001) y cáncer de riñón (p = 0,002). Además, el grupo con NMH tenía niveles mucho más altos de péptidos natriuréticos (p <0,001) y creatinina (p = 0,008) que los pacientes con cáncer de mama. Discusión. La comparación con los datos poblacionales mostró que nuestros pacientes eran más frecuentemente fumadores, hipertensos y diabéticos, y en menor proporción tenían hipercolesterolemia. Conclusiones. Los pacientes connuevo diagnóstico de cáncer, candidatos a tratamiento médico potencialmente cardiotóxico, tienen mayor prevalencia de factores de riesgo CV significativos y por tanto deben ser seguidos por un equipo multidisciplinar durante el proceso terapéutico.
Dexmedetomidina en la sedación del paciente críticamente enfermo: ¿Cuál el la relación riesgobeneficio respecto de otros agentes?
Authors: Villamizar Rueda Omar , Guerrero Eraso Cristian Javier , Arismendy Agudelo Isabel Cristina , Sierra Torres Liseth Paola , Ortega Sierra Michael Gregorio
Published: December 2024

La dexmedetomidina es un agonista altamente selectivo de los receptores α-2 adrenérgicos con efectos sedantes, ansiolíticos, simpaticolíticos y analgésicos. Se ha planteado que su interacción al nivel del sistema nervioso central puede tener un efecto favorable sobre el delirium, la estructuración del sueño y la reactividad al estrés en pacientes críticamente enfermos y ventilados mecánicamente. Sin embargo, su interacción hemodinámica desencadena un efecto bifásico hemodinámico queprovoca hipertensión transitoria, seguida de bradicardia e hipotensión, por lo que algunos autores la consideran insegura. Diversos estudios primarios recientes y metanálisis han conseguido resultados interesantes sobre diversos desenlaces que facilitan la interpretación del posible beneficio con este agente en comparación con los sedantes tradicionales como propofol o midazolam. Mejor aún, se ha descrito un posible beneficio adicional sobre la electrofisiología cardíaca, que podría beneficiarespecialmente a pacientes con antecedentes de arritmia cardíaca, lo cual disminuye el riesgo de morbilidad y mortalidad en la atención crítica. Considerando la relevancia de este tópico, el objetivo de esta revisión es brindar un acercamiento de la relación riesgo-beneficio de la dexmedetomidina en la sedación del paciente críticamente enfermo, respecto de otros agentes utilizados tradicionalmente sobre la base de la evidencia más reciente.
Celulitis por scedosporium apiospermum
Authors: Miauro Cynthia Victoria , Rueda Angarita Ángela , González Yasmin Soledad
Published: December 2024

Las infecciones por Scedosporium apiospermum son parte de las micosis de baja frecuencia causadas por hongos emergentes. El hábitat natural de estos hongos es el suelo, el agua y la materia orgánica en descomposición. Aunque la inhalación es la vía de exposición de mayor preocupación, las infecciones sistémicas secundarias a ingestión, trauma o contaminación de heridas por conidios o esporangiosporas ambientales no son infrecuentes. Presentamos un caso de celulitis en un paciente masculino de 68 años que fue ingresado en nuestra institución debido a una infección de piel y partes blandas en miembro inferior izquierdo. Posteriormente, se informó Scedosporium apiospermum en los cultivos por lo que recibió tratamiento ajustado con voriconazol. Resaltamos la importancia de este caso dado su baja frecuencia y alta mortalidad asociada a su resistencia a la mayoría de los antifúngicos disponibles, especialmente en huéspedes inmunocomprometidos cuyo pronóstico dependerá deun diagnóstico rápido y un tratamiento antifúngico temprano.
Exploration and Practice of Teaching Reform in Digital Electronic Technology Course Driven by Artificial Intelligence and OBE
Authors:   Nanning College of Technology, China, Chen Feifei , Chen Sihui ,   Nanning College of Technology, China
Published: December 2024

With the rapid development of science and technology, the field of digital electronics technology is changing rapidly, which puts forward higher requirements for talent training. This paper addresses the urgent need for digital electronics technology course reform and proposes a reform implementation strategy under the dual-drive model of artificial intelligence and OBE. By updating the teaching content to introduce new technologies, adopting flipped classrooms and task-driven teaching methods to enhance learning interest, building training centers to strengthen practical teaching, and establishing a diversified evaluation system to pay attention to the learning process, curriculum reform is comprehensively promoted. The implementation of these strategies not only improves the quality of teaching and students' learning effectiveness but also lays a solid foundation for cultivating digital electronic technology talents with innovative spirit and practical ability. This teaching reform adapts to the development trend of the industry and promotes the organic convergence of the education chain, talent chain, and industrial chain, innovation chain.
Emotional Expression and Singing Techniques in Vocal Singing Research
Authors:   Geely University, China, Sun Zhongqiao
Published: December 2024

In vocal singing, the combination of emotional expression and singing skills is an important part of music performance, emotional expression can be fully demonstrated through singing skills, at the same time, the realisation of singing skills can also promote the enhancement of the level of emotional expression in vocal singing, and the organic combination of the two in vocal singing has an important promotional value in promoting the enhancement of the singing effect. Therefore, this paper discusses the relationship between emotional expression and singing skills in vocal singing, analyses the combination strategy of emotional expression and singing skills in vocal singing, and on this basis further researches the enhancement of emotional expression and singing skills in vocal singing, aiming to provide effective guidance for vocal learners and help them to achieve the perfect integration of emotion and skills in singing.
Financial Performance Evaluation of Vanke Group under the Background of Digital Transformation — Empirical Analysis based on the Factor Analysis Method
Authors:   Guangdong Technology College, Zhaoqing, China, Li Changlong , Liu Zhibang ,   Guangdong Technology College, Zhaoqing, China
Published: December 2024

As the digital transformation has become an inevitable trend of global economic development, enterprises are facing unprecedented challenges and opportunities. In the context of digital transformation, this paper aims to analyze the financial performance by factor analysis. Article first summarizes the digital transformation of the global economy, industrial structure and the profound influence of enterprise operations, special emphasis on the data in the modern economy and the core position of artificial intelligence for social progress, then, in Vanke group, for example, introduced the digital transformation, including information stage, digital stage and intelligent stage of the concrete implementation and results. By comparing the financial performance changes of Vanke Group before and after the digital transformation of Vanke Group, it is found that the digital transformation has effectively improved the financial performance of Vanke Group.
The Challenges to Provide Qualified Healthcare, Role of Human Capital, Job Performance Job Satisfaction and the Impact on the Economic Growth. A Review of Literatures
Authors:   Doctoral Management of Economic and Business Faculty Samarinda Mulawarman University, Indonesia, Nurjanti Lely
Published: December 2024

Healthcares prevention and treatment services quality is provided by qualified human capital that has good employee performance and good empoloyee satisfaction. Human capital is the main source of the economic and it has an important role as an economic asset that produce productivity, that is important for developing economic growth and prosperity of the country. The quality of healthcare prevention and treatment services is the service products that also can be the part of the economic and economic growth, that is produced by qualified human capital as human and management resources as the subject that can be supported by good employee performance & satisfaction and good hospital structures, infrastructures, technology and services.

Quality of healthcare is patient oriented highest level of healthservice and treatment to provide safe, informative, efficacious, effective, fast-accurate and reliable healthcare services according to WHO updated clinical guidelines and standards of structures (management, system,policy) & infrastuctures (building etc) that have been adjusted by the time and adapted to the environment & cultures, which meet patient needs & demands with good performance and satisfied provider. Quality of healthcare provides a consistent delightfully and satisfactorily feeling of the patient and healthcares provider. Healthcare quality definitions common to all stakeholders involve offering patient oriented cares that contributes to patient well being satisfaction (known as patient satisfaction) and that is provided by good and satisfied employees performance as human capital resources that supported by good stuctures and infrastructures. Human capital is an economy asset, its is defined as the capacity and the stock of ability of human being to produce an income that important as fundamental source of economic growth. Human Capital refers to people knowledge-training-education, skill-ability-experiences, leadership-organization-motivation. creativity, innovation (organization, marketing, service & technology adoption) and health of individual in workforce. Job performance is an employee aptitude/ability in the accomplishment of a given task that are determined in their job description. that is measured against pre set standards of accuracy, completeness, cost and speed. Job satisfaction measure the personal pshycological effect .Job satisfaction is a pleasurable or positive emotional state resulting from the assessment/evaluative of people job or job experiences, that can be measured as cognitive (knowledge), affective (emotional) and behavioral components.
Theoretical Perspectives on Psychosocial Behavior of Adolescents in Education: A Systematic Review
Authors: Khanal Ganesh Prasad , Timilsena Narayan Prasad
Published: December 2024

A complex interplay of cognitive, emotional, and social factors shapes the psychosocial development of adolescents in educational settings. This article comprehensively reviews the major theoretical perspectives that inform our understanding of adolescent psychosocial behavior in education. We examine key theories, including Erikson's psychosocial development theory, Bandura's social cognitive theory, Bronfenbrenner's ecological systems theory, and Vygotsky's sociocultural theory, alongside more contemporary frameworks like resilience theory and self-determination theory. By analyzing how these theories conceptualize adolescent behavior in the context of learning, peer relationships, and identity formation, we highlight their relevance to current educational challenges. The review further explores the procedures for applying these theories in research, identifying opportunities for integrating multiple perspectives to support adolescent development in educational settings.
Habilidades del futuro para jóvenes estudiantes en México
Authors:   Centro Universitario de Ciencias
            Económico Administrativas de la Universidad de Guadalajara, López García Dea Nicté , Pelayo Ruelas Sergio ,   Escuela Preparatoria no. 18
            de la Universidad de Guadalajara
Published: December 2024

El mundo actual y el ritmo en el que se transforma y evoluciona han provocado una
disrupción en diferentes ámbitos sociales, uno de ellos, el educativo. Una gran cantidad
de adolescentes y jóvenes se enfrentan al reto de adaptarse a nuevos modelos educativos,
al tiempo que se les exige desarrollar habilidades necesarias para incursionar en un
campo laboral en el que, las innovaciones tecnológicas y la globalización, lo tornan
cada vez más incierto. Los cimientos de esta revolución informacional tuvieron origen en
San Francisco, California, en un punto llamado Silicon Valley. Castells (2004), en su
libro La era de la información: economía, sociedad y cultura, analiza las condiciones
actuales de interacción y acuña el término de sociedad red, misma que se caracteriza por
tener como base a la revolución tecnológica y su principal interés se encuentra en
acumular conocimientos e información.