bluuebunny/crossref_metadata_2025 huggingface dataset:
Determining The Impacts of Educational Intervention Based on PLST Extended Care On Caregiving Methods and Improved Exposure To Challenging Behaviors of People With Dementia (PWD): A Mixed-Methods Study
Authors: Zamani-Alavijeh Fereshteh , Zahed Shakiba , Emami Maryam , Bazargan-Hejazi Shahrzad , Barekatain Majid , Hassanzadeh Akbar , Eslami Ahmad Ali
Published: November 2021

Background: Psychological events in people with dementia (PWD) lead to behavioral disorders that require targeted planning for caregivers on how to adapt to these behaviors. A progressively lowered stress threshold (PLST) model provides effective interventions for caregivers to adapt to the behaviors of people with dementia (PWD). Therefore, this study aims to determine the impacts of educational intervention based on the progressively lowered stress threshold extended (PLSTE) model on the caregiving of people with dementia (PWD) in Isfahan, Iran.Methods: This exploratory mixed methods study was initially conducted with a qualitative approach to content analysis type from May 2016 to June 2018. Data were collected in a qualitative stage through in-depth nonstructured interviews with 29 People with Dementia (PWD)'s caregivers using the "new comment" command and then analyzed. The researcher designed a multisectional questionnaire, including demographic characteristics, knowledge measurement, and monitoring the practice of caregivers. The validity of the questionnaire was verified by a panel of experts, and its reliability was confirmed using the Cronbach alpha coefficient (knowledge section 0.838 and practice section 0.802). To adjust the intervention program, the educational content based on the PLSTE model was used for 38 caregivers available at two elderly nursing centers in Isfahan. The data were collected immediately and one month after the educational intervention using a questionnaire.Results: According to the results of the qualitative section of this study, the researcher was able to add a cultural and belief class and then the related intervention method to the PLST model. In the quantitative part, paired t-test indicated that the mean scores of knowledge, caregiving practice, and exposure to Challenging Behaviors (CB) in all dimensions of practice immediately and one a month after intervention were significantly higher than the mean scores before intervention (P < 0.05).Conclusion: Considering the impacts of this intervention, educating caregivers with PLST extended the care model is recommended, with a specific focus on cultural and traditional issues of society, to improve the knowledge and practice of caregivers in caregiving skills and appropriate exposure to challenging behaviors people with dementia (CBPWD).Trial registration No. IRCT20180421039370N1 -2019-01-11-http://www.irct.ir
Number of Antenatal Care Utilization and Associated Factors Among Pregnant Women in Ethiopia: Zero-Inflated Poisson Regression of 2019 Intermediate Ethiopian Demography Health Survey.
Authors: Arefaynie Mastewal , Kefale Bereket , Yalew Melaku , Adane Bezawit , Dewau Reta , Damtie Yitayish
Published: November 2021

Background
The frequency of antenatal care enhances the effectiveness of the program to reduce maternal and child mortality and morbidity. The aim of the study was to determine the number of antenatal care and associated factors in Ethiopia by using 2019 intermediate EDHS.
Methods
Secondary data analysis was done on 2019 intermediate EDHS. A total of 3,916.6 weighted pregnant women were included in the analysis. Zero-inflated Poisson regression analysis was done by Stata version 14.0. Incident rate ratio and odds ratio with a 95% confidence interval were used to show the strength and direction of the association.
Result
About one thousand six hundred eighty eight (43.11%) women were attending four and more antenatal care during current pregnancy. Attending primary education (IRR= 1.115, 95% CI: 1.061, 1.172), secondary education (IRR=1.211, 95% CI: 1.131, 1.297) and higher education (IRR=1.274, 95% CI: 1.177, 1.378), reside in poorer household wealth index (IRR= 1.074, 95% CI: 1.01, 1.152), middle household wealth index (IRR= 1.095, 95% CI: 1.018, 1.178), rich household wealth index (IRR=1.129, 95% CI: 1.05, 1.212) and richer household wealth index (IRR=1.186, 95% CI: 1.089, 1.29) increases the number of antenatal care utilization. The frequency of antenatal care was less likely become zero among women attending primary (AOR=0.434, 95% CI: 0.346, 0.545), secondary (AOR=0.113, 95% CI: 0.053, 0.24), higher educational level (AOR=0.052, 95% CI: 0.007, 0.367) in the inflated part.
Conclusion
The number of antenatal care utilization is low in Ethiopia. Being rural, poorest household index, uneducated and single were factors associated with low number of antenatal care and not attending antenatal care at all. Improving the educational coverage and wealth status of women is important to increase coverage of antenatal care.
Neutrons magnetic Mass
Authors: geilhaupt manfred
Published: November 2021

In Quantum Physics the Spin of an elementary particle is defined to be an „intrinsic, inherent“ property. The same to the magnetic moment (μ) due to the spin of charged particles - like Electron (me) and Proton (mp). So the intrinsic spin (S=1/2h-bar) of the electron entails a magnetic moment because of charge (e). However, a magnetic moment of a charged particle can also be generated by a circular motion (due to spin) of an electric charge (e), forming a current. Hence the „orbital motion of charge“ around a „mass-nucleus“ generates a magnetic moment by Ampère’s law. This concept leads to an alternative way calculating the neutrino mass (mν) while discussing the beta decay of a neutron into fragments: proton, electron, neutrino and binding Energy. The change of neutrons magnetic moment during the decay process based on energy and spin and charge conservation allows to calculate the restmass of the neutrino: mν = 0.10(20)eV.
Gloss and Modelling Studies of Stone Polishing, Using Linear Polishing Machines With Rotating Heads
Authors: Coelho Adriano Manuel Sá , Pereira José Carlos Garcia , Amaral Pedro Miguel Gomes Abrunhosa , Rosa Luís Manuel Guerra da Silva
Published: November 2021

The ornamental stone industry has always played an important role in the world economy, particularly in building construction. Polishing the slabs to increase its gloss, is an important processing operation to enhance the beauty and richness of these natural materials. Many industrial polishing machines rely on rotating heads movement along zigzag trajectories, eroding the surface as stochastically as possible, to avoid scratches and other visual defects caused by paths too symmetric. The displacement of the polishing head after a single zigzag movement and after a single rotation have been used to quantify the polishing process as these two parameters are related with the final stone gloss and are a measure of the efficiency of the polishing process. Applying experimental and new computer simulation techniques, we studied the influence of these two tool displacement parameters on the final stone gloss, and acquired insight into the accuracy of the simulation techniques that were applied here for the first time. We concluded that: 1) a clear correlation can be established between experimental and simulation data; 2) the two displacement parameters represent an effective way to control the quality and efficiency of the polishing process; 3) there is a limit for the gloss acquired through polishing processes, so polishing above a given threshold decreases the efficiency without increasing the quality.
Association Mapping, Trait Variation, Interaction and Population Structure Analysis in Cucumber (Cucumis Sativus L.)
Authors: Kumar Rahul , Munshi Anilabh Das , Behera Tusar Kanti , JAT GOGRAJ SINGH , Choudhary Harshwardhan , Talukdar Akshay , Dash Prasanta
Published: November 2021

In several regions of the world, low productivity in this crop is attributed to several factors including poor understanding of the genomic complexity of important traits associated with fruit quality and yield. Therefore, genome wide association analysis was performed for important traits using simple sequence repeats (SSR) markers. Significant variation was recorded for all the studied traits in 78 cucumber genotypes under two environments (open field and net house) which indicated that the constituted association panel was suitable for association mapping. Genotyping was done using 60 highly polymorphic SSRs. By performing genome scanning out of 60 SSR markers, using mixed linear model (MLM) approach 4 and 6 markers explained an average of 23.93% and 17.37 % of the trait variation under net house and open field condition, respectively. Based on MLM approach two markers on 3rd chromosome (UW084942) and 4th chromosome (UW062953) found to be associated with the average fruit weight (g) under both net house and open field condition. Population structure analysis revealed four distinct sub-populations that corroborated with the geographical origin as well as fruit quality and quantitative traits. The four sub-populations (A–D) had fixation index percentage (Fst) equal to 24.35 29.48, 37.17 and 8.97 respectively, supporting the existence of moderate population structures. Therefore, the extensive phenotypic and genotypic characterization, population structure, and markers associated with critical traits provided in this study will facilitate marker assisted improvement programs in cucumber.
Concentrations and Risk Assessment of Metals, Antifouling Paint Particles and Microplastics in Coastal Sediment of a Marina in Simon’s Town, South Africa
Authors: Sparks Conrad , Awe Adetunji
Published: November 2021

Maintenance of maritime vessels includes the removal of paint from hulls that ultimately ends up the aquatic environment. Coastal maritime vessel maintenance is a source of metals, antifouling paint particles (APPs) and microplastics (MPs) that ends up in the coastal environment. Simon’s Town is a small urban town in False Bay, Cape Town, South Africa, where maritime activities take place (there is a naval harbour, marina and boat maintenance facility). The aim of this study was to measure metals, APPs and MPs in Simon’s Town, to assess the impact of maritime activities and a storm water pipe in a protected marina. Sediment samples were collected from 6 sites during winter 2018. Sediment and extracted APPs were analysed for metal content and MPs characterised based on type (visual and polymer), colour and size. Metal and MP fragment concentrations were highest at the slipway of a boatyard / maintenance facility, decreasing with increased distance from the slipway. MP filaments were highest close to the storm water outfall pipe. Our results suggest that boating maintenance facilities are potential sources metals and MP APP fragments, with storm water pipes potential sources of MP filaments. Various indices applied to assessed the potential impacts of metals and MPs, suggests that these contaminants have the potential to severely adversely impact the intertidal ecosystem investigated.
TGF-β1 Induced Deficiency of Linc00261 Promotes Epithelial-mesenchymal-transition and Stemness of Hepatocellular Carcinoma via Modulating SMAD3
Authors: Chen Zhanjun , Xiang Leyang , Ou Huohui , Fang Yinghao , Xu Yuyan , Liu Qin , Hu Zhigang , Li Longhai , Huang Yu , Li Xianghong , Yang Dinghua
Published: November 2021

Emerging evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the metastasis and recurrence of hepatocellular carcinoma (HCC).Kinds of lncRNAs were found to be involved in regulating epithelial-mesenchymal transition (EMT) or stem-like traits in human cancers, however, the molecular mechanism and signaling pathways targeting EMT and stemness remains largely unknown. Previously, we found that linc00261 was down-regulated in HCC and associated with multiple worse clinic pathological parameters and poor prognosis. Here, we show that linc00261 was down-regulated in TGF-β1 stimulated cells, and forced expression of linc00261 attenuated EMT and stem-like traits in HCC.Linc00261 also inhibited the tumor sphere forming in vitro and decreased the tumorigenicity in vivo. Furthermore, we revealed that linc00261 suppressed the expression and phosphorylation of SMAD3 (p-SMAD3), which is a core transcriptional modulator in TGF-β1 signaling mediated EMT and the acquisition of stemness traits. A negative correlation between linc00261 and p-SMAD3 was determined in HCC samples.Conclusion: Our study revealed that linc00261suppressed EMT and stem-like traits of HCC cells by inhibiting TGF-β1/SMAD3 signaling.
AIDS-Defining Opportunistic Illnesses in Qatar, 2000-2016 : A Cohort Study
Authors: Ali Maisa , Gassim Mahmoud , Elmaki Nada , Goravey Wael , Alkhal Abdulatif , Almaslamani Muna , Alsoub Hussam
Published: November 2021

Background
Human immune deficiency virus (HIV) infection remains a major health problem since discovery of the virus in 1981. Globally, since introduction of antiretroviral therapy, AIDS related death felt by more than 25% between 2005 &2011. Also, HIV related opportunistic infections (OIs) are less common, especially with use of prophylaxis to prevent such infections (3). We aim in this study to assess the incidence of HIV infection and related OIs in Qatar for 17-year period, and assess the spectrum of these infections, risk factors and treatment outcome.
Methods
retrospective cohort study for all HIV infected patients registered in Qatar from 2000-2016. Incidence of HIV infection and related opportunistic illness was calculated per 100000 population. Demographic and Clinical characteristic were compared between two groups of patients with and without opportunistic illness.
Results
of 167 cases with HIV infection 54 (32.3%) of them had opportunistic illness. The average incidence rate of HIV infection over 17 years is 0.69 per 100000 population, and the incidence rate for opportunistic illness is 0.27 per 100000 population, figure1. The most common opportunistic illness is pneumocystis jirovecii pneumonia (PCP) 25% of cases, followed by CMV retinitis 7.2%, Tuberculosis 5.4%, Toxoplasmosis 4.2% and less than 2% for Kaposi sarcoma, lymphoma and cryptococcal infection.
A novel nanoparticle system targeting damaged mitochondria for the treatment of Parkinson's disease
Authors: Chen Yue , Yu Lina , Zhang Jinyu , Yao Lifen , Yan Hongji , Tian Weiming
Published: November 2021

BackgroundMitochondrial damage is one of the primary causes of neuronal cell death in Parkinson's disease (PD). In PD patients, the mitochondrial damage can be repaired or irreversible. Therefore, mitochondrial damage repair becomes a promising strategy for PD treatment.MethodsWe use hyaluronic acid nanoparticles (HA-NPs) of different molecular weights to protect the mitochondria and salvages the mild and limited damage in mitochondria. Our HA-NPs with 2,190 kDa HA can improve the mitochondrial function of SH-SY5Y cells and PTEN induced putative kinase 1 (PINK1) knockout mouse embryo fibroblast (MEF) cells. In cases of irreversible damage, we use NPs with ubiquitin specific peptidase 30 (USP30) siRNA to promote mitophagy. Meanwhile, by adding PINK1 antibodies, our NPs can selectively target the irreversibly damaged mitochondria, preventing the excessive clearance of healthy mitochondria.ResultsOur HA-NPs with 2,190 kDa HA can protect the mitochondria and salvage the mitochondrial function of the mild and limited damage conditions in both SH-SY5Y cells and PINK1 knockout MEF cells. NPs with USP30 siRNA and PINK1 antibodies can selectively target and promote the clearance of irreversibly damaged mitochondria both in vitro and in vivo.ConclusionsWe successfully designed and developed NPs for the treatment of PD that can target different stages of mitochondrial damage. This strategy is expected to overcome the problems associated with the excessive clearance of healthy mitochondria and has great potential for clinical applications. Our study provides a novel strategy for PD treatment.
PGE2 Promotes Neovascularization and M2 Macrophage Recruitment in Murine Wet-Type AMD Models
Authors: Wang Xiaolu , Zhan Pengfei , Cui Yuqing , Cao Yujuan , Bao Xun , Wu Meili , Yang Qian , Yang Jiahui , Zheng Haohan , Zou Jian , Xie Tianhua , Cai Jiping , Yao Yong
Published: November 2021

Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the pathogenesis of choroidal neovascularization (CNV) in exudative AMD (wet AMD). This study describes the effects of cyclooxygenase-2 (COX2)/prostaglandin E2 (PGE2) signalling on the M2 macrophage recruitment and CNV formation of wet AMD. In a mouse model of laser-induced wet AMD, the mice received an intravitreal injection of celecoxib (a selective COX2 inhibitor). Optical coherence tomography (OCT), fundus fluorescein angiography (FFA), choroidal histology of the CNV lesions, and biochemical markers were assessed. The level of PGE2 expression was high in the laser-induced CNV lesions. M2 polarization and CNV development were significantly less after celecoxib treatment. E-prostanoid1 receptor (EP1R)/protein kinase C (PKC) signalling was involved in M2 polarization and interleukin-10 (IL-10) production of bone marrow-derived macrophages (BMDMs) in vitro. In addition, IL-10 was found to induce the proliferation and migration of human choroidal microvascular endothelial cells (HCECs). Thus, the PGE2/EP1R signalling network serves as a potential therapeutic target for CNV of the wet-type AMD.
Comparison of Statistical Models For Estimating Intervention Effects Based On Time-To-Recurrent-Event In Stepped Wedge Cluster Randomized Trial Using Open Cohort Design
Authors: Oyamada Shunsuke , Chiu Shih-Wei , Yamaguchi Takuhiro
Published: November 2021

Background: There are currently no methodological studies on the performance of the statistical models for estimating intervention effects based on the time-to-recurrent-event (TTRE) in stepped wedge cluster randomised trial (SWCRT) using an open cohort design. This study aims to address this by evaluating the performance of these statistical models using an open cohort design with the Monte Carlo simulation in various settings and their application using an actual example.Methods: Using Monte Carlo simulations, we evaluated the performance of the existing extended Cox proportional hazard models, i.e., the Andersen-Gill (AG), Prentice-Williams-Peterson Total-Time (PWP-TT), and Prentice-Williams-Peterson Gap-time (PWP-GT) models, using the settings of several event generation models and true intervention effects, with and without stratification by clusters. Unidirectional switching in SWCRT was represented using time-dependent covariates.Results: Using Monte Carlo simulations with the various described settings, the PWP-GT model with stratification by clusters showed the best performance in most settings and reasonable performance in the others. The only situation in which the performance of the PWP-TT model with stratification by clusters was not inferior to that of the PWP-GT model with stratification by clusters was when there was a certain amount of follow-up period, and the timing of the trial entry was random within the trial period, including the follow-up period. The AG model performed well only in a specific setting. By analysing actual examples, it was found that almost all the statistical models suggested that the risk of events during the intervention condition may be somewhat higher than in the control, although the difference was not statistically significant.Conclusions: The PWP-GT model with stratification by clusters had the most reasonable performance when estimating intervention effects based on the TTRE in SWCRT in various settings using an open cohort design.
Using cognitive computing for a secure cloud in the energy sector
Authors: S. Eftimie
Published: November 2021

The evolving changes in the energy industry have led to increased efforts in adopting cloud technologies. In this paper, we explore specific security needs of the energy sector and propose a solution that uses the latest advances in cognitive computing to detect malicious insiders, one of the top threats that prevent cloud adoption.
Experience from the implementation of multimedia approach to teaching for developing professional competence
Authors: I. Serbezova
Published: November 2021

Multimedia approach has been increasingly used in the education of university students in recent years. It is not only modern but also particularly necessary in the process of teaching and acquiring knowledge and skills – this is a methodology that is not sufficiently developed. Unfortunately, there are few sources presenting experience from its practical implementation. Often, preference is given to traditional instructional methods, strategies and approaches as in time they have proven effective in acquiring the knowledge and skills necessary in practice. In this aspect, multimedia approach offers great flexibility and high potential as a teaching tool in education. On the whole, the content of this report presents the author’s extensive experience and her ambiguous conclusion that the modern psychopedagogical profile of the digital generation of students, compulsory requires introduction of innovative instructional technologies. The implementation of this relatively new approach to teaching students results in more profound gain of theoretical knowledge and more effective development of practical skills and experience, which in turn forms a higher level of professional competence. The findings of this research supplement the existing evidence of the importance of applying innovative instructional practices and support the implementation of multimedia mixed approach to educational process. Students highly appreciate the implementation of various audio-visual training methods, find them useful in their preparation for practical exams and in building skills before, during and following the academic lectures. The article targets lecturers and supervisors of future specialists in various professional fields, students at higher schools, teachers interested in these issues.
Dehydration at seafarers – prevention, symptoms and approaches
Authors: G. Koleva
Published: November 2021

Dehydration may be caused of either limited water intake, excessive loss of water, or both. The lack of water is much too serious than that of food. Every healthy man loses approximately 2,5% of the general body water a day (which is around 1,200 l) along with the urine, the air which he breathes out, perspiration and the gastrointestinal tract. If we are to put in addition to this loss increased perspiration, as a result from a row of factors caused by external environment, or some disease states in which the sailors on ships are exposed, dehydration could lead to a shock and death in just a few hours. The sailors’ training in reference to the importance of this state, is of significant matter for them to prepare themselves properly before going on board, and consciously prevent dehydration during their voyage.
The role of Bulgarian institutions in the maritime critical infrastructure resilience
Authors: N. Dimitrov
Published: November 2021

The author considers the maritime critical infrastructures resilience as a government responsibility for protection and service continuation and is carried out by the joint efforts of infrastructures operators, state and local institutions, and private actors shaped in a complex system. He gives reasons for the exactly type of the system based on local character of incidents and having common management and separated responsibilities.
Evolution of the Romanian Naval Industry in the European context
Authors: S. Lupu
Published: November 2021

This article analyses, in the unitary conception, the whole evolution of the Romanian Naval Industry, following the next issues:  Development the infrastructure in the Romanian Naval Industry;  Evoluţion of the shipbuilding capacity;  Development shipbuilding production;  Also, this article, try to estabilish the pozition of Romanian Naval Industry in the hierarchy of the European Continent. We mention that our analysis base on statistical data that was published in different sources, archives data and own calculation for the main economic and technical indicators.
FEEDING FREQUENCY AND DENSITY OF MICROALGAE PASTE (CHLORELLA VULGARIS) IN THE DIET OF DEKALB UNDER BATTERY CAGE SYSTEM
Authors:   Agriculturist 1, Livestock Program, Department of Agriculture, Regional Field Office 4- MIMAROPAOdiongan, Romblon, Philippines., F. Gan Hannah , N. Falculan Ken ,   Faculty, College of Agriculture, Romblon State University, Odiongan, Romblon, Philippines.
Published: November 2021

Poultry products are the major source of animal protein for most people throughout the world and egg production is the major index of performance of commercial layer business and the avenue in the potential increase ofincome from the enterprise which focuses onegg yield, weight of eggs, and increasing their quality production to enhance economic performance.Microalgae is certainly an interesting solution, it aims to increase its value as an animal feed additive in new commercial applications. The experimental research was used in this study to evaluate the laying performance and egg quality of DeKalb under two feeding regimen such as feeding density andfrequency of microalgae paste Chlorella vulgaris under battery type cage system. The experiment was conducted in acompletely randomized designwith a period of 30 days with 81 Dekalb of the same age. The experimental diet used were commercial feeds,microalgae paste and feeding frequencies of 4 times, 3 times and 2 times.Egg characteristics such as total number of eggs, egg weight (g), egg length (mm), egg width (mm) and shape index (%) were computed based on the data from feeding frequency and density. The costs of feeds and price of grown Dekalb and some material used were used in the computation of return on investment. Based on the result, the effect on the external quality of eggs fed under different feeding densities and frequencies on egg production, egg width, egg weight, egg length and shape index resulted to not significantthe null hypothesis was accepted. The internal quality, the effect of different feeding densities on albumen height, albumen weight and yolk width also statistically not significant. Supplementation of microalgae Chlorella vulgaris on hen diet can be included as a dietary supplement for laying hens up to 80% of the diet to produce quality eggs.
Precipitation to remove calcium ions from stabilized human urine as a pre-treatment for reverse osmosis
Authors: Courtney Caitlin , Randall Dyllon G.
Published: November 2021

Concentration of Ca(OH)2 stabilized urine by reverse osmosis (RO) has the potential to cause CaCO3 scaling on the membranes. The aim of this research was to determine whether the addition of carbonate salts could be used to precipitate CaCO3 prior to RO concentration and how to accurately dose the salts. Dosing of NaHCO3 or Na2CO3 reduced the calcium concentration to <0.18 mmol L−1, whilst maintaining a pH > 11. This is the pH threshold for enzymatic urea hydrolysis in urine, but above the operating pH range of most membranes. However, the pH could be decreased by adding an acid. Measuring conductivity as a proxy for the calcium concentration was found to be an effective method to determine the dose of salt required. Simulations with other carbonate-producing salts (KHCO3, MgCO3, and NH4HCO3) were also shown to be effective. However, NH4HCO3 ($0.53 m−3 urine) was the only other salt comparable in cost to NaHCO3 ($0.49 m−3 urine) and resulted in a final pH within the normal operating range of membranes. The addition of NH4HCO3 would add extra N to the urine rather than sodium ions when dosing NaHCO3. The choice of salt will ultimately depend on what liquid fertilizer composition is desired.
Editorial note
Authors: Assounga Alain
Published: November 2021

Editorial note
Prenatal causes of kidney diseases
Authors: Koleganova Nadezda , Piecha Grzegorz , Slabiak-Blaz Natalia , Ritz Eberhard
Published: November 2021

Deleterious environmental factors during pregnancy influence fetal development and increase the risk of cardiovascular and kidney disease in adult offspring. Undernutrition, protein restriction, excess salt, corticosteroids, or placental insufficiency disturb kidney development, causing a lower number of nephrons (referred to as nephron underdosing). This in turn leads to hypertension and accelerated loss of kidney function in the adult life of the offspring. The nephron underdosing can be observed with or without intrauterine growth restriction. A lower number of nephrons have been confirmed in humans with hypertension.
Myelodysplastic syndrome and extracapillary glomerulonephritis: is there a link?
Authors: Hamzi M. A. , Mahtat E. M. , Hassani K. , Asserraji M. , Benyahia M. , Oualim Z.
Published: November 2021

Introduction: The association of myelodysplastic syndrome and extracapillary glomerulonephritis is exceptional. Only two other cases have been reported. Reported case: A 52-year-old patient with a history of myelodysplastic syndrome developed rapidly progressive glomerulonephritis. Renal biopsy identified extracapillary glomerulonephritis.Discussion: The association of myelodysplastic syndrome with glomerulopathy is rare and often regarded as fortuitous. Only a few cases are described in literature on the subject. A relationship between the two diseases is possible but the causal link between these two diseases remains unknown. Conclusion: The notion that myelodysplastic syndrome may be associated with various glomerular nephropathies involves looking for renal disease in this haematologic disorder.
Editorial note
Authors: Assounga Alain
Published: November 2021

In this issue of the African Journal of Nephrology (AJN Vol 18, No 1) we publish original articles ranging from the prevalence of chronic kidney disease in an African population in general, to the role of HIV in kidney disease. An elegant study of fractionated heparin use in haemodialysis is also presented. Continuous ambulatory peritoneal dialysis is an important modality of renal replacement to be considered in Africa in view of its ease of operation. However, beware of potential complications including sclerosing peritonitis as reported in Cape Town (South Africa).As in the past, this issue covers a wide variety of topics with contributions from diverse authors from south to west and North Africa. On behalf of the editorial board, I wish to take this opportunity to thank all of the authors and reviewers who have contributed to this issue of the journal, as well as to the readers for their sustained interest in the African Journal of Nephrology.
Haemodialysis vascular access function in dialysis patients at the Kenyatta National Hospital
Authors: Ndinya Florentius O. , Kayima Joshua K. , Magabe Peter C. , McLigeyo Seth O. , Were Antony J. , Odinya George O.
Published: November 2021

Background: The number of patients requiring renal replacement therapy (RRT) worldwide has been on the rise. Vascular access is the lifeline for these patients when haemodialysis (HD) is the treatment of choice. Access-related morbidity is a leading cause of hospitalization so that the function and patency of access are essential for the optimal management of patients. There is a need to recognize when a vascular access is dysfunctional because intervention must maintain function as well as preserve future vascular access sites. Methods: This was a cross-sectional study that evaluated the haemodialysis vascular access function in patients undergoing chronic haemodialysis at the Kenyatta National Hospital, Nairobi, Kenya. Peak access blood flow rates, urea reduction ratio (URR) and Kt/V were analysed in 150 patients.Results: The temporary (non-tunnelled) central venous dialysis catheters had poor function, with only 48% achieving a mean blood flow rate > 300 mL/min. The comparable rate for arteriovenous fistulae (AVF) was 88% and for tunnelled dialysis catheters 82%. One-quarter of the patients had a URR < 65%. Higher mean blood flow rates were associated with higher URR (P = 0.004) and Kt/V (P = 0.009) values. AVF stenosis was present in 12.5% and thrombosis in 3% of patients. Aneurysms were the commonest AVF complication (47%) but were not haemodynamically significant. Conclusions: Tunnelled haemodialysis catheters offered adequate blood flows and achieved adequate delivered dialysis, comparable to arteriovenous fistulae. Non-tunnelled catheters delivered poor blood flow rates and dialysis dose. Greater blood flow rates were associated with a higher delivered dialysis dose. There is a need for routine surveillance and affordable interventional procedures to prevent loss of vascular access.
Acknowledgement to reviewers 2018
Authors: Davids M Razeen
Published: November 2021

The editors of AJN wish to thank the colleagues who generously gave of their time and expertise to review manuscripts for us during 2018. We greatly appreciate their contribution to the quality of the work that we publish.
Central pontine myelinolysis: not just a low sodium issue
Authors: Titus Gideon , Vazi Luthando , Sabela Tholakele , Chothia Mogamat-Yazied
Published: November 2021

Osmotic demyelination syndrome is a rare complication following treatment of chronic hyponatraemia. We describe a case of a middle-aged man known with hypertension and hypothyroidism who presented with a reduced level of consciousness and a generalised convulsion. Laboratory results revealed severe hyponatraemia and hypokalaemia. Following rapid overcorrection of the serum sodium concentration, his level of consciousness remained unchanged, and he developed quadriplegia. Magnetic resonance imaging of the brain revealed central pontine myelinolysis (CPM). The patient died 3 weeks after hospitalisation. Other than rapid overcorrection of chronic hyponatraemia, this case also highlights the important role of potassium in the pathogenesis of CPM. Therefore, when severe chronic hyponatraemia is accompanied by hypokalaemia, the latter should be corrected first to further reduce the risk of CPM.
In memoriam: Anthony Jude Omolo Were
Authors: Twahir Ahmed
Published: November 2021

Dr Anthony Were, a stalwart of the Kenyan and African nephrology communities, died on 21 November 2020 at the age of 64.
Una sinopsis de Braunia (Hedwigiaceae, Bryopsida) en México, con la lectotipificación de Braunia andrieuxii
Authors: De Luna Efraín
Published: November 2021

Antecedentes y Objetivos: Se conocen cuatro especies de Braunia en México: Braunia andrieuxii, B. secunda, B. squarrulosa y B. plicata. Anteriormente no se había realizado ningún estudio taxonómico de las especies de Braunia en México. Además, entre varios especímenes colectados por “Andrieux” disponibles, no hay certidumbre sobre cual ejemplar en particular es el tipo.
Métodos: Las cuatro especies de Braunia conocidas en México y áreas vecinas en el Sur de Estados Unidos de América, Centroamérica y las islas del Caribe se estudiaron juntas por primera vez. Con base en más de 450 especímenes de varios herbarios, se presenta un tratamiento taxonómico y una clave para las especies de Braunia en esta región geográfica.
Resultados clave: Se describen e ilustran las cuatro especies. Se selecciona como lectotipo para B. andrieuxii el ejemplar Andrieux 23 localizado en el herbario BM, con isolectotipos en los herbarios BM y NY. Se provee una clave para la identificación de las especies de Braunia en México, el sur de los EUA, Centroamérica y el Caribe.
Conclusiones: Los atributos morfológicos más probables que sean informativos para la distinción de las cuatro especies en México son los márgenes de la hoja, los ápices foliares, las células foliares superiores y los esporofitos. El ápice foliar es hialino y dentado solo en B. plicata, mientras que el ápice es verde y entero o escabroso en las otras tres especies de Braunia en México. Las células foliares superiores son cuadradas a corto-rectangulares en B. andrieuxii y B. plicata; mientras que las células superiores son alongadas en B. secunda y B. squarrulosa.
Management of athlete achievement development, central java student sports coaching and training center
Authors: Winarni Nunuk Indah , Sugiharto Sugiharto , Yogaswara Andre
Published: November 2021

One of the ways that the government restricts the development of regional elite sports is to seek to establish a variety of athlete development facilities. The purpose of this study is to determine and describe the implementation of performance development management for athletes in the Central Java Student Sports Development and Training Center (PPLOP). The research method uses explanatory research techniques. The research was conducted at the Central Java Student Physical Education and Training Center (BPPLOP). Research data sources are individuals directly related to PPLOP, including PPLOP athletes, athletes and other related party managers, coaches, and performance development coordinators. Techniques for collecting data through observations, interviews and documents. The results show that the performance management of PPLOP athletes in Central Java has achieved the best results in performance development, education, academic development and religious development. The process of improving PPLOP Central Java performance is correct, as evidenced by the performance of athletes in sports, science, and religion. The existence of the promotion and dismantling system has become a reference for the school and the PPLOP Center in Central Java to implement performance promotion management.Manajemen pembinaan prestasi atlet pemusatan pembinaan dan latihan olahraga pelajar Jawa Tengah  AbstrakSalah satu cara pemerintah dalam mengkondisikan pembinaan cabang olahraga unggulan di daerah adalah dengan mengupayakan berdirinya beberapa institusi pembinaan atlet. Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan implementasi manajemen pengembangan kinerja atlet di Pusat Pembinaan dan Latihan Olahraga Pelajar (PPLOP) Jawa Tengah. Metode penelitian menggunakan teknik explanatory research. Penelitian ini dilakukan di Balai Pemusatan Pendidikan dan Latihan Olahraga Pelajar (BPPLOP) Jawa Tengah. Sumber data penelitian adalah individu yang berhubungan langsung dengan PPLOP, antara lain pengurus, pelatih, koordinator pengembangan kinerja atlet PPLOP, atlet dan pihak terkait lainnya. Teknik pengumpulan data melalui observasi, wawancara, dan dokumen. Hasil penelitian menujukkan bahwa penerapan manajemen kinerja atlet PPLOP di Jawa Tengah mendapatkan prestasi terbaik dalam pengembangan kinerja, pendidikan, pengembangan akademik, dan pengembangan keagamaan. Proses peningkatan prestasi PPLOP Jawa Tengah sudah baik dan benar, terbukti dari prestasi para atlet di bidang olahraga, sains dan agama. Adanya sistem promosi dan degradasi menjadi acuan bagi pelaksanaan manajemen pembinaan prestasi di sekolah maupun di lingkungan Balai PPLOP Jawa Tengah.
The effect of virtual community for physical activity on student's physical activity in the era of pandemic Covid-19
Authors: Damayanti Imas , Gustira Adi
Published: November 2021

The purpose of this study was to increase the physical activity of students in the era of the COVID-19 pandemic, to maintain and improve body fitness. A quantitative approach using the experimental design method then with a one - group pretest - posttest design research design. Then the population in this study were UPI students in semesters 2-3, who had low physical activity. with a sample of 12 female students. This research was conducted during the first month of the first week for the pre-test, then the 2nd and 3rd weeks for treatment and ended with the post test for the 4th week, the data was collected using the accelerometer actgraph instrument and the Global Physical Activity Questionnaire (GPAQ). The results of the mets value for the pretest 1.153 to 1.27 for the post-test score, for the average total stepcount value for the pretest 2. 619 to 3340, while the mets value for the pretest GPAQ was 432.67 and then for the posttest value 529.58. The conclusion is that there is a significant influence from the virtual community for physical activity on the physical activity of students during the Covid-19 pandemic.Pengaruh virtual community for physical activity terhadap aktivitas fisik mahasiswa di era pandemi Covid-19AbstrakPenelitian ini adalah untuk meningkatkan aktivitas fisik mahasiswa di era pandemi covid -19, untuk menjaga dan meningkatkan kebugaran tubuh. Pendekatan penelitian adalah penelitian kuantitatif dengan metode eksperimen desain one - group pretest - posttest design. Sampel pada penelitian ini adalah mahasiswi UPI semester 2 sampai dengan 3 yang mempunyai aktivitas fisik rendah. Penelitian ini dilaksanakan selama satu bulan, minggu pertama untuk pre-test, lalu minggu ke 2 dan 3 untuk perlakuan dan diakhiri dengan post-test untuk pada minggu ke-4. Instrumen pengambilan data yang digunakan diantaranya accelerometer actigraph dan Global Physical Activity Questionnaire (GPAQ). Hasil dari nilai mets untuk pretest 1,153 menjadi dan meningkat menjadi 1,27 pada akhir perlakuan. Nilai stepcount total rata rata pretest 2619 meningkat menjadi 3340, dan nilai mets pada GPAQ pretest 432.67 meningkat menjadi 529.58. Kesimpulan penelitian ini bahwa terdapat pengaruh yang signifikan dari virtual community for phisical activity terhadap aktivitas fisik mahasiswa pada era pandemi Covid-19
The effect of sports massage with meditation on myalgia disorders
Authors: Graha Ali Satia , Yuniana Rina
Published: November 2021

Myalgia is pain that occurs in the muscles that can interfere with daily activities. Sports massage and meditation is an alternative to reduce the feeling. The purpose of this study was to determine the effect of sports massage on overcoming myalgia disorders. This study uses a quantitative quasi-experimental method with this type of design using the equivalent time series sample design. The population in this study was a total of 36 masseurs who worked in sports injury therapy massage centers on the 4th floor of UNY Plaza. The sample was determined using purposive sampling technique and obtained a number of 15 samples. This type of research is a quasi-experimental, using a pretest-posttest design. Research subjects were given 3 (three) repetitions of treatment, namely the first week, the second week and the third week. The data analysis technique in this study used a t-test (paired t-test), in test I, test II and test III, the overall significance was obtained with a value of 0.000 (sig. 0.05). The conclusion in this research is sports massage with meditation can reduce myalgia disorders.Pengaruh sports massage dengan meditasi terhadap gangguan myalgiaAbstrakMyalgia merupakan nyeri yang terjadi pada otot yang dapat menganggu aktivitas sehari-hari. Sports massage dan meditasi merupakan salah satu alternatif untuk mengurangi rasa nyeri. Tujuan penelitian ini untuk mengetahui pengaruh sports massage dengan meditasi terhadap gangguan myalgia. Penelitian ini menggunakan metode quasi eksperimen kuantitatif dengan jenis rancangan menggunakan the equivalent time series sample design. Populasi dalam penelitian ini adalah masseur sejumlah total 36 yang bekerja di tempat masase terapi cedera olahraga di Plaza UNY lantai 4. Penentuan sampel menggunakan teknik purposive sampling dan diperoleh sejumlah 15 sampel. Subjek penelitian diberikan 3 (tiga) kali pengulangan perlakuan yaitu minggu ke- I, minggu ke-II dan minggu ke-III. Teknik analisis data dalam penelitian ini menggunakan uji-t (paired t-test). pada uji I diperoleh nilai 0,000 (sig. 0,05), uji II diperoleh nilai 0,000 (sig. 0,05) dan uji III diperoleh nilai 0,000 (sig. 0,05). Kesimpulan dalam penelitan ini adalah sports massage dengan meditasi dapat mengurangi gangguan myalgia
Pengaruh olahraga di ruang terbuka dan ruang terbuka hijau terhadap inflamasi paru
Authors: Alawi Cecep Muhammad , Ray Hamidie Ronald Daniel , Rusdiana Agus
Published: November 2021

Tujuan penelitian ini adalah untuk menganalisis pengaruh olahraga di ruang terbuka dengan paparan polusi dan olahraga di ruang terbuka hijau terhadap inflamasi paru. Metode true eksperiment dan desain The Randomized Posttest-Only Control Group Design digunakan dalam penelitian ini. 24 ekor tikus putih galur wistar jantan dewasa dengan berat 200-250 gram berusia 8-9 minggu dibagi secara acak menjadi empat kelompok, NE (Non Exercise) sebagai kontrol, NE+Pol (Non Exercise + polusi Particulate Matter 2.5  75 ppm dan Carbon Monoxide Meter 100 ppm), Ex (Exercise 5 kali/minggu selama 4 minggu), Ex+Pol (Exercise + polusi). Penanda inflamasi Tumor Necrosis Factor-αlpha (TNF-α) dianalisis menggunakan Western Blotting. Untuk mengetahui perbedaan yang signifikan antar kelompok, analisis ANOVA satu jalur dan uji Post Hoc digunakan. Hasil penelitian menunjukkan bahwa kelompok eksperimen olahraga dengan paparan polusi memiliki kadar TNF-α yang signifikan lebih tinggi dibandingkan kelompok kontrol (Ex+Pol: 1,63 AU; NE: 0,54 AU; p=0,000). Tidak ada perbedaan yang signifikan antara kelompok eksperimen olahraga di ruang terbuka hijau dengan kelompok kontrol (Ex: 0,80 AU; NE: 0,54 AU; p=0,357). Dapat disimpulkan bahwa terdapat pengaruh olahraga di ruang terbuka dengan paparan polusi terhadap inflamasi paru. Dan hasil lain menunjukkan bahwa tidak terdapat pengaruh olahraga di ruang terbuka hijau terhadap inflamasi paru.The effect of exercise in open spaces and green open spaces on lung inflammationAbstractThe purpose of this study was to analyze the effect of exercise in open spaces with exposure to pollution and exercise in green open spaces on lung inflammation. True eksperiment and The Randomized Posttest-Only Control Group Design was used in this study. 24 adult male wistar white rats weighing 200-250 grams aged 8-9 weeks were randomly divided into four group, NE (Non Exercise) as control, NE+Pol (Non Exercise + exposure pollution Particulate Matter 2.5 75 ppm and Carbon Monoxide Meter 100 ppm), Ex (Exercise 5 times/week for 4 weeks), and Ex+Pol (Exercise + exposure pollution). The inflammatory marker Tumor Necrosis Factor-αlpha (TNF-α) was analyzed using Western Blotting. To find out the significant differences between groups, one-way ANOVA and Post Hoc test were used. The results showed that the exercise + exposure to pollution had significantly higher levels of TNF-α than the control group (Ex+Pol: 1,63 AU; NE: 0,54 AU; p=0,000). There was no significant difference between the exercise in green open space and the control group (Ex: 0,80 AU; NE: 0,54 AU; p=0,357). It can be concluded that there is an effect of exercise in an open space with exposure to pollution on lung inflammation. And other results show  there is no effect of exercise in green open spaces on lung inflammation.
Анализ суперкаверн, формируемых при высокоскоростном движении в воде группой ударников
Authors: Ищенко А.Н. , Буркин В.В. , Дьячковский А.С. , Чупашев А.В. , Саммель А.Ю. , Рогаев К.С. , Сидоров А.Д.
Published: November 2021

The analysis of supercavities formed during the high-speed motion in water of two closely spaced supercavitating strikers is performed. By comparing of geometric characteristics of supercavities, the possibility of qualitative assessment of the degree of influence of closely spaced strikers is shown. By the example of two strikers, the characteristic distance between them was determined, at which the minimum mutual influence of the strikers on each other is observed.
Самопроизвольное (спонтанное) вскипание затопленных струй, генерируемых при коллапсе паровых пузырьков
Authors: Адамова Т.П. , Чудновский В.М. , Елистратов Д.С.
Published: November 2021

The effect of secondary spontaneous boiling of submerged jets formed during the collapse of vapor bubbles during the bulk boiling of water subcooled to the saturation temperature at the end of a laser optical fiber is experimentally discovered.