bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of School Discipline from the Students’ Point of View
Authors: Konstantinou Ioannis Ch. , Chatzisavva Ekaterini A. , Logotheti Stamatoula G.
Published: October 2022

Regarding the topic of discipline management in the educational practice, there are legitimate concerns and many pedagogical questions that need to be addressed, given that the attainment of discipline is a significant issue in schools. The main purpose of this research is to determine whether primary and secondary school students have comprehended the role of discipline and rules in school and, in particular, in educational practice. In addition, related issues are investigated, such as the student’s undisciplined or problematic behavior, the causes of indiscipline phenomena, as well as, the pedagogical means available to the teacher for creating propitious conditions of communication and relationship with the students, which contribute to the effective management of both the educational process and the challenging matters related to the attainment of classroom discipline and in general, of school discipline. As it is indicated by the findings of this research, the responses of the students of primary and secondary school enlighten the questions addressed in the questionnaire. This paper concludes with the research outcomes.
Sustentabilidad del sistema de producción de limón persa en Martínez de la Torre, Veracruz
Authors: Franco Valderrama Ana Maryury , Caamal Cauich Ignacio , Pat Fernández Verna Gricel , Rámirez-Hernández Javier Jesús
Published: October 2022

La sustentabilidad es un proceso que tiene por objetivo encontrar el equilibrio entre el área económica, social y ambiental. El sector agrícola en México ha sufrido una serie de cambios durante años, estos cambios se han visto reflejados directamente en el ambiente, ya que la agricultura convencional impacta sobre los recursos naturales. La investigación, se realizó en el Municipio Martínez de la Torre, Veracruz, siendo este el más importante en la producción de limón Persa (Citrus latifolia Tanaka), el objetivo de la investigación fue evaluar la sustentabilidad en la producción de limón persa convencional, utilizando el marco para la evaluación desistemas de manejo de recursos naturales incorporando indicadores de sustentabilidad (MESMIS). Se evaluó el área económica resultando ser la más fortalecida debido a que durante el año hay producción de limón persa, el beneficio costo obtenido es económicamente aceptable, el área ambiental arrojo que los productores realizan muy poco la conservación de los recursos naturales, el área social fue la más débil en sus indicadores, por lo que se deriva en gran parte a la falta de capacitación técnica, en la poca participación familiar y en la falta de integración de la mujer en las prácticas agrícolas.
Skills Identification for Healthcare Facility Engineering Technicians
Authors: Call Steven , Hurtado Kristen , Sullivan Kenneth
Published: October 2022

The purpose of this research was to identify the technical skills that are necessary for competency as a facility engineering technician (FET) in the healthcare built environment. The Delphi method was used to draw upon the knowledge and experience of healthcare facility engineering managers and technicians to identify and prioritize baseline technical skills, as well as to identify proficiency levels for the skills. A total of 73 skills were identified as necessary for healthcare FET baseline competency including areas of wood, plastic, and composite; flooring; doors; plaster and gypsum board; mechanical support; fire support; plumbing; electrical; and safety and compliance. Of these 73 skills, 35 were deemed key with strong agreement consensus.

Successfully recruiting, training, and maintaining a competent FET workforce is essential but challenging for healthcare organizations, in part because of the lack of formal education programs and an unclear path of entry into the profession. The results of this research are valuable in that they can be used to develop training for the healthcare FET workforce. Trainers can use the findings of this research when developing curriculum and determining which skills to emphasize. Healthcare organizations can use the findings to assess current capabilities across staff, to determine whether there are gaps in needed skills and to begin developing strategic programs in response to the challenges of attracting and retaining competent FETs. This research suggests other types of jobs need to be examined to move toward developing a more complete understanding of the skills and capabilities necessary for the spectrum of the facility engineering workforce (from technical to managerial) to address attrition, recruitment, retention, and succession challenges.
Diasporic consciousness in contemporary Indian women’s fiction in English: at a glance
Authors: Kadam Dipali M.
Published: October 2022

Diasporic literature is a pivotal term in literature that includes the literary works of the authors who are the outsiders for their native country but their work is deeply rooted in homeland by reflecting native culture, background, displacement and so on. Indian women’s literary work is at the forefront of diasporic literature. The advent of Indian women novelists on the literary horizon is an important development in the Indian English literature. These women writers have also contributed to other genres, such as drama, poetry and short stories, not only in English but also in regional languages like Hindi, Marathi, Bengali, Punjabi, Tamil, Kannada and so on. Some modern women writers flourish their writing in the form of fables as a literary genre in an impressive way to focus on the specific themes. In last two decades, Indian women’s writing in English is blossomed, both published in India and abroad. The present paper is the review of diasporic consciousness in select works of contemporary Indian women novelists. It focuses on the attempt to highlight the quest for identity of those women who played a crucial role in defining themselves through their literary work in diasporic background.
Structural factors of migration of the population of the Russian Far East
Authors:   The Russian Presidential Academy of National Economy and Public Administration, the  Far-Eastern  institute of management – branch of RANEPA, Efremenko V. F.
Published: October 2022

The migration outflow of the population, which has been occurring for 30 years in all subjects of the Russian Federation located in the Far East, is becoming a stable phenomenon that threatens the security of the country on its eastern borders. The measures taken by the Government of the Russian Federation have not made significant improvements in the migration situation, which puts forward the urgent problem of revealing the true essence of the observed phenomenon of migration outflow of the population, including the analysis of the structure of departures. As our research shows, the initiative core of the migration outflow are persons who have received higher education, including those with PhD and doctorate degrees. In the structure of the negative balance of migration in the Far Eastern macro-region, their share is 40 percent, while in the structure of the permanent population of the Far East it is half as much and does not exceed 20 percent. Migration flows from persons consisting of highly educated personnel characterize the transition of social reproduction to its innovative type. This feature of the post-industrial stage of society's development was noted in the middle of the twentieth century. The recipients of such migration flows, generated by persons with higher education and qualifications, are the centers of science, high-tech production, innovative development. The revealed pattern allows us to conclude that the solution to the problem of migration outflow of the population of the Far East consists in the formation and development of agglomerations in the macroregion that carry out their advanced socio-economic development on the basis of the latest achievements of science and technology, which creates the best conditions for the creation of knowledge-intensive jobs attractive to highly qualified personnel.
Problems of the Trans-Baikal territory within the framework of political sociology
Authors:   The Trans-Baikal State University, Beidina T. E.
Published: October 2022

The article is devoted to the problems and priorities of the Trans-Baikal region. The purpose of the study is to study the current state of the socio-political sphere of the Trans-Baikal region and show its important place in the Far East. To achieve this goal, the following tasks were solved:1. To reveal the features of the socio-political situation in the Trans-Baikal Territory. 2. To study the activities of the authorities of the Trans-Baikal territory in the implementation of socio-political problems in Trans-Baikal.Taking into account the degree of development of the problem, its insufficient knowledge, the following methods were used: induction, deduction, comparative research, systemic, structural-functional methods. The methodology of this article includes: 1. Literature analysis regarding the implementation of national projects in the Russian Federation. 2. Economic and statistical method. Statistical data on the implementation of regional projects on the territory of the Trans-Baikal territory were used. As a result of the study, the author came to the following conclusions. 1. The Trans-Baikal territory has multiple problems associated with its geographical location, unique resource base, population decline due to low birth rates and population decline due to migration, complex socio-economic processes both in social policy and in political power. 2. For the development of the Trans-Baikal territory, it is advisable to carry out the following activities: further implementation of national projects, construction of social facilities – schools, kindergartens, hospitals and clinics, their repair under the state program for the development of the Far East. 3. Plans for the development of the Trans-Baikal territory are also expedient, providing for the creation of jobs, budget growth at the expense of the economy, and wage increases. These measures are of practical importance and provide for a change in the Charter of the Trans-Baikal territory and the solution of the socio-economic and political problems of the region.
Estrategias para la adaptación de un sistema de captación de precipitaciones en la vereda de las Palmas del municipio de Tunja (Boyacá)
Authors: Torres Torres Manuel , Escarraga Pachón Luis Fernado , Patiño Pacheco Monica Jovanna
Published: October 2022

Contextualización En la actualidad el reto de la agricultura es alimentar a una población cada día en ascenso, para ello se debe tener una constante oferta del recurso hídrico para los sistemas productivos. Al día de hoy en el departamento de Boyacá, la productividad agrícola se ha visto perjudicada por el efecto del cambio climático. Esto en relación con los cambios de temperaturas altas durante el día y bajas temperaturas en las noches, con el fenómeno del niño, un aumento en la intensidad y frecuencia de las lluvias para el fenómeno de la niña. Lo que ocasiona pérdidas en la calidad y rendimiento de los cultivos. Por ello, una medida de mitigación es colectar el agua lluvia de techos de viviendas rurales, que puedan ser aprovechadas para utilizarla agua de regadío, agua para sistemas de pecuarios y sistemas hidropónicos o agua para la vivienda rural.  
Vacío de conocimiento:  La falta de medidas como la recolección de aguas lluvias para sus hogares o para sus sistemas productivos, de implementación de estrategias que podría mejorar la disponibilidad del recurso hídrico en épocas de sequía. Además, No hay estudios sobre captación de aguas lluvias en zonas rurales en Boyacá.
Propósito: Obtener información por medios de datos climatológicos durante dos años para determinar las estrategias para la adaptación de un sistema de captación de precipitaciones y determinar la cantidad de agua captada en una cubierta de una vivienda rural.
Metodología: Se recolectaron los datos de pluviosidad durante dos años, para obtener un volumen aproximado en los episodios invernales. Se analizó datos de factores climáticos, se determinó los datos pluviométricos, el área de captación y el volumen recolectado en fincas.
Resultados y conclusiones: Se obtuvieron los siguientes datos totales por año; para el 2020 se captó 442 mm de agua y en el año 2021 se ha obtenido 357 mm por precipitación y se recogió 64.090 litros o 64,0 metros cúbicos para el año 2020 y 51.165 litros o 51,1 metros cúbicos para año.
10-Year-Childhood Malignancy Profile Province-Wide in Indonesia (2009-2018): Yogyakarta Pediatric Cancer Registry
Authors: Veerman Anjo JP , Purwanto * , Armytasari Inggar , Ritter Julie , Widjajanto Pudjo
Published: October 2022

Background: In 2001, Dr. Sardjito Hospital initiated a
systematic hospital-based registry, Yogyakarta Pediatric Cancer Registry
(YPCR). This study aims to present an epidemiological profile of
childhood malignancies diagnosed in Dr. Sardjito General Hospital and
compare it with the previous study Methods:
Childhood cancer was diagnosed in children aged 0-18 years, from January
2009 to December 2018, and analyzed. Childhood malignancies were
categorized based on age, sex, and disease group according to the
International Classification of Childhood Cancer (ICCC-3). An estimated
annual average incidence rate (AAIR) of childhood cancer was calculated.
We visualized the number of patients and their regions of origin by
geographic mapping. Result: There were 1,788 new cases
registered in YPCR during the study period. Of these, 58% were male,
with a male-to-female.4:1.0. The mean age at diagnosis was 6.3 years
old, the median age was 5 years and 56% of cancers were diagnosed in
the age group of 0-5 years old. The most common diagnosis category was
leukemia (ICCC-3 Category I), which accounted for 60% of all childhood
malignancies. The three most common diagnoses included: ALL (44%), AML
(13%), and retinoblastoma (6%). Of the 1,077 patients diagnosed with
leukemia, 58% were males, most often diagnosed at 0-5 years old (53%).
There were 679 patients registered with solid tumors mostly diagnosed at
0-5 years old (57%). The AAIR of leukemia and solid tumors was 26.8 and
17.5 per million, respectively. Conclusion: There was an
increase in the number of childhood malignancies in 2009-2018 compared
to the 2000-2009 study. The number of patients referred to our hospital
increased, indicating a better referral system to the pediatric cancer
center. This study is expected to provide data on the hospital-based
pediatric cancer registry in Indonesia and promote systematic pediatric
cancer registries in other centers.
A nonlocal diffusion SIR epidemic model with nonlocal incidence rate and free boundaries
Authors: Chen Yujuan , Zhou Li
Published: October 2022

This paper is concerned with the spreading or vanishing of an epidemic
disease which is characterized by a nonlocal diffusion SIR model with
nonlocal incidence rate and double free boundaries. We prove that the
disease will vanish if the basic reproduction number R 0 < 1 ,
or the initial area h 0 , the initial datum S 0 , and the expanding
ability µ are sufficiently small even that R 0 > 1 ,
and the disease will spread to the whole area if R 0 > 1 ,
when h 0 is suitably large or h 0 is small but µ is large enough.
Moreover, we also show that the long-time asymptotic limit of the
solution when vanishing happens.
Surgically-treated hemoptysis and alveolar hemorrhaging resulting from severe mitral regurgitation: A case report
Authors: Yamaguchi Daisuke , Tokui Toshiya , Narukawa Takahiro , Murakami Masahiko , Sekoguchi Tomotake , Inoue Ryosai , Hirano Koji , Maze Yasumi , Ito Hisato
Published: October 2022

Cardiac etiologies of hemoptysis are less common. One such etiology
includes mitral regurgitation. In patients with hemoptysis and
unilateral consolidation, mitral valve regurgitation should be
considered, and careful chest auscultation and cardiac assessment may
assist in making an early diagnosis.
EARLY DETECTION OF PLACENTA SUCCENTURIATE IN PREVENTING COMPLICATIONS: A CASE REPORT
Authors: Rijal Yasoda , Pokharel Simankan , Kunwar Asma , Shrestha Nischal , Bhattarai Shiva , Adhikari Yagya , Shrestha Prezma
Published: October 2022

Succenturiate placenta can be associated with vasa previa, retained
placenta, post-partum hemorrhage and infection. Prior knowledge of
presence of succenturiate placenta can be helpful to take quick and
rational decisions during the labor. We present a case of placenta
succenturiate suspected at 34+3 weeks of gestation using findings from
ultrasonography.
Atypical truncal necrobiosis lipoidica: When dermoscopy enlightens clinics
Authors: THABOUTI Marwa , Fetoui Nadia Ghariani , Mani Oumaima , Belkahla Marouène , Mokni Sana , Sriha Baderedine , Ghariani Najet , Denguezli Mohamed
Published: October 2022

Necrobiosis Lipoidica (NL) is a rare granulomatous skin condition
typically occurring in lower extremities. We report an atypical case of
NL and we highlight the role of dermoscopy in the diagnostic approach.
Development of new candidate oncological therapeutic enzymes: A comparative structural and kinetic study of recombinant L-asparaginases
Authors: AKTAR Berin YILMAZER , GEORGAKIS Nikolaos , Labrou NE , Turunen Ossi , BİNAY Barış
Published: October 2022

L-asparaginases (L-ASNase, EC 3.5.1.1) are amidohydrolases catalysing
the conversion of L-Asn to L-Asp and ammonia and to a lower extent L-Gln
to L-Glu (L-glutaminase activity, L-GLNase). This enzyme is exploited as
an anti-neoplastic agent to treat acute lymphoblastic leukaemia.
Currently, Escherichia coli and Erwinia chrysanthemi
L-ASNases are used as oncological drugs. However, harmful side-effects
and hypersensitivity reactions are the main limitations of these
therapeutics. A link has been proposed between L-GLNase activity and
harmful side effects. Therefore, finding of new L-ASNases with low
glutaminase activity, thus potentially with lower side effect risk, is
important for medical applications. A detailed biochemical
characterization of a wide range of L-ASNases linked with in silico
approaches could contribute for discovering better oncologic ASNase drug
candidates. In this study, ten bacterial and yeast L-ASNase genes
belonging to type I and II class of L-ASNase families, were synthesized
and cloned into T7 bacterial expression vector for production in
E. coli BL21 cells. The optimum pH and temperature of the
expressed L-ASNases were at pH 7.0-9.0 and 35°C-50°C range,
respectively. While the optimum temperature and pH of the ten L-ASNases
were similar as those previously reported for type I and II L-ASNases,
none of them displayed detectable glutaminase activity. Structural
comparisons of these ten ASNases with quite much differing kinetic
properties showed that the residues with a catalytic role are conserved
and some differences at position 59 close to the substrate may affect
the kinetic parameters. The type I L-ASNase from Lachancea
thermotolerans yeast ( LtASNase) exhibited the highest specific
activity of 313.82 U/mg and catalytic efficiency for L-Asn. Therefore,
LtASNase is a promising enzyme for further investigation in
pharmaceutical applications.
Lifestyle and Prevalence of Overweight and Obesity among Secondary School Teachers in Uzo-Umahi LGA of Enugu State, Nigeria
Authors: HO Okudu
Published: October 2022

A cross sectional, descriptive study was carried out on rural secondary teachers in Uzo – Umahi LGA of Enugu State, Nigeria. The study was designed to elicit information on lifestyle, prevalence of overweight and obesity using questionnaire. The results showed that majority of the male teachers (70.2%) consume alcohol while soft drink was consumed majorly among the female teachers (74.7%). Smoking was low (2.1%). Meal skipping was generally high (males 63.8%; females 59%). Lunch was most skipped among the male teachers (31.9%) while breakfast was most skipped among the females. Major reason for skipping meal was attributed to lack time. Report on physical activities showed that more male teachers (87.2%) participate in exercise than the female teachers (66.3%); with many of them spending about 60 -120minutes on exercise per week. Prevalence of overweight and obesity grade 1 was more in the female teachers (36.1 and 7.2%). Results on waist-hip ratio classification (WHR) showed that majority of the male teachers (91.5%) were at low risk of having cardiovascular diseases, while majority of the female teachers (75.9%) were at high risk of cardiovascular diseases. There was significant relationship between socioeconomic status with physical exercise, time spent on exercise and meals skipped
Impact of Consciousness Energy Healing Treatment on the Physicochemical and Thermal Properties of Vitamin D3 (Cholecalciferol)
Authors: S Jana
Published: October 2022

Vitamin D3 is a fat-soluble vitamin, which helps in the absorption of minerals like calcium, magnesium, iron, zinc, and phosphate and also responsible for other biological activity. The aim of the research work was to evaluate the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical, thermal, and behavioral properties of vitamin D3 using PSA, PXRD, DSC, and TGA/DTG analytical technique. The vitamin D3 powder sample was divided into two parts, one part of the sample was considered as control (no Biofield Energy Treatment was provided), while the other part was treated with the Trivedi Effect®-Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Dahryn Trivedi and termed as a treated sample. The particle size values in the treated vitamin D3 powder sample were significantly decreased by 21.46%, 18.29%, 17.87%, and 18.11% at d10, d50, d90, and D(4,3) compared to the control sample. Thus, the specific surface area of the treated sample (0.0317 m2/g) was significantly increased by 16.97% compared to the control sample (0.0271 m2/g). The PXRD data showed that the peak intensities and crystallite sizes of the treated vitamin D3 powder sample were significantly altered ranging from -85.18% to 286.11% and -62.06% to 237%, respectively compared to the control sample. The average crystallite size of the treated sample (339.92 nm) was significantly decreased by 6.94% compared with the control sample (365.25 nm). The melting point and latent heat of fusion of the treated sample were slightly increased by 0.49% and 1.01%, respectively compared to the control sample. The total weight loss was decreased by 0.83%; hence the residue amount was significantly increased by 42.09% in the treated sample compared with the control sample. The maximum thermal degradation temperature was significantly increased by 9.82% in the treated sample compared with the control sample. The Trivedi Effect®- Consciousness Energy Healing Treatment generates a new polymorphic form of vitamin D3 which might offer better solubility, dissolution, absorption, bioavailability, and be thermally more stable compared with the control sample. Hence, the Biofield Energy Treated vitamin D3 would be more beneficial to maintain the overall quality of life and increase the intestinal absorption of several vital minerals like calcium, magnesium, iron, zinc, and phosphate in the body. Similarly, it would be very much useful in designing novel nutraceutical/pharmaceutical formulations for the better therapeutic responses against hypovitaminosis D, rickets, osteoporosis, cardiovascular diseases, diabetes mellitus, cancer, mental disorders, infections, multiple sclerosis, etc.
Development of a Bread Product for Coeliac People Made form Rice, Chía and Amaranth Flour, by Mean of a Mixture Design
Authors: MC Beltrán-Orozco
Published: October 2022

It was developed a bread for celiac people, based on a mixture of rice flour, burry amaranth and chía seed, as well as, hydrocolloids (alginate, guar and xantana gums) and sodium caseinate. Using the methodology of Mix Design. It was evaluated the volume and texture of the loaf, as well as, the quality of the crumb and the crust of the loaves and the taste of the loaves like response variables. The flours used were tested by immunological assays to ensure the absence of gluten in them. By means of the numerical optimization process, (Design Expert 5 statistical program) the best formula was obtained. The best result was obtained with the use of 9% sodium caseinate (based on% baker) and 2% guar gum, and it was possible to develop bread with good physical and sensory characteristics, safe for the consumption of celiac people.
Practical Methods to Improve the Quality and Safety of FreshCut Fruits: A Review
Authors: V Chiabrando
Published: October 2022

The ready-to-eat fruit and vegetable market has rapidly grown in recent years due to the health benefits associated with these foods and to the increased health consciousness of consumers with busy lifestyles and increased purchase power. Nevertheless, ready-to-use commodities are more perishable than the original materials. The main factors affecting the loss of consumer acceptability are discoloration, enzymatic browning, dryness and texture loss. These parameters determine the visual appearance of the fruits. For this reason, the fruit processing industry requires the development of techniques capable of keeping safe shelf-life, preserving the original visual and organoleptic fresh-like characteristics of fresh-cut products. Another problem associated with the ready-to-eat products, is the microbiological growth. The metabolism of molds and yeasts is responsible for the qualitative decay of minimally processed fruits, so the products decontamination became essential. Natural antimicrobials, ozone, chlorine dioxide, UV and cold gas plasma are some of the different treatments proposed. In combination with these treatments, some actions are carried out to limit the oxidative browning and the firmness loss. Ascorbic acid is the compound most extensively used to avoid the oxidative browning of the fruits, however nowadays there are many alternatives, like chemical or physical treatments. The edible coatings could be effective systems to preserve fresh cut fruits quality, their actions are due to the barrier forming against external agents; in addiction, they could carry functional ingredients (antioxidant, antimicrobial, calcium salts). In conclusion, the treatments aimed to preserve minimally processed fruits quality could be chemical or physical, innovative or more established, cheap or expensive or they could require complex equipment. This review describes the most significant contributions regarding preservation of fresh-cut fruits in order to evaluate their effectiveness in preserving quality traits.
Evaluation of the Consciousness Energy Healing Treated Berberine Chloride Using PXRD, PSA, and DSC Analysis
Authors: S Jana
Published: October 2022

Berberine is one of the well-known traditional Chinese medicines and it has been significantly effective against various ailments. This study was performed to evaluate the effect of the Trivedi Effect®-Consciousness Energy Healing Treatment on its physicochemical properties by using PXRD, PSA, TGA/DTG, and DSC analytical techniques. The sample was divided into two parts; the first part was considered as a control sample (without treatment), while the second part was received the Consciousness Energy Healing Treatment remotely by the Biofield Energy Healer, Gopal Nayak and denoted as the treated sample. The PXRD peak intensities and crystallite sizes were altered ranging from -28.78% to 115.15% and - 15.76% to 241.38%, respectively; however the average crystallite size was increased significantly by 23.05% in the treated sample compared to the control sample. The particle sizes were significantly increased by 16.89% (d10), 34.41% (d50), 21.88% (d90), and 22.85 % {D (4,3)}, which resulted in the significant increase in the specific surface area by 14.74% in the treated sample compared to the control sample. The thermal analysis indicated 3.98% increase in weight loss and 3.64% decrease in the residue weight of the treated sample compared to the control sample. The latent heat for the 1st, 2nd, 3rd, 4th, 5th, and 6th peaks of the treated sample were significantly altered by 224.78%, 7.93%, 8.92%, - 9.05%, -45.82%, and 10.93%, respectively, compared to the control sample. The overall analysis indicated that the Trivedi Effect®-Consciousness Energy Healing Treated berberine chloride might possess better solubility, absorption, and thermal stability compared to the untreated sample. Thus, the Trivedi Effect® could be used in improving the bioavailability of berberine chloride and might be used for designing the novel nutraceutical/pharmaceutical formulations to combat various diseases.
Role of Foreign Direct Investment in Research and Development of Pharmaceutical Industries in India
Authors: N Karunakaran
Published: October 2022

Multinational companies (MNCs) have responded to India’s movement towards compliance with the WTO intellectual property agreement, TRIPS, by increasing the quantity and quality of foreign direct investment (FDI) in the areas of pharmaceutical research and development (R&D) and manufacturing. Drug prices do not necessarily provide an accurate signal of consumer’s preferences in all cases. However, it is not always clear why the market sustains high prices for some new drugs when cheaper alternatives of seemingly comparable quality are available. By contrast, MNCs have adopted a more cautious attitude toward patenting and commercialization of pharmaceutical products in India, waiting to see how Indian courts and patent office’s interpret the new laws, and awaiting the enactment of data exclusivity legislation
COVID-19 Pandemic in Teaching English for Specific Purposes: Impacts on The Remote Teaching Process of Front Office Teachers
Authors: Mahendra I Dewa Gede Oka , Adnyayanti Ni Luh Putu Era
Published: October 2022

Distance teaching is an option for all educators to continue learning activities during the COVID-19 pandemic. This study analyzes how front office teachers in Vocational High Schools implement remote teaching. The participant of this study was a front office teacher at a Vocational High School. This research begins by looking for an overview or making observations to teachers regarding teacher problems in implementing remote teaching. Data was collected qualitatively by using several methods, namely: Observation and Interviews. Data were analyzed through theory with the qualitative descriptive analysis method. The results showed that the most problems faced by teachers when implementing distance teaching were the lack of student response and internet connection problems. Front office teachers must also be able to adapt their teaching strategies to the technology that will be used as a learning medium. The researcher suggests the teacher make an activity that can control the students to practice on how to apply their new knowledge about the material given by the teacher.
The Effect of Wordwall Based Media on Students' Procedure Text Achievement in Ninth Grade Students
Authors: Adnyana I Nyoman Gede Wisnu , Dewi Kadek Sintya
Published: October 2022

The goal of this study was to analyse if there was a difference in student achievement in class IX when utilizing the Wordwall application to write procedure texts. Post-test In this study, only the Control Group Design was used. The students in this study were grade IX. One complete group cluster random sampling was utilized to collect the sample. There were two sample groups in this study: an experimental group that was taught using the Wordwall application, and a control group that was taught using the traditional technique or without the use of the Wordwall program. A post-test was used to collect data after the two groups received different treatments for seven meetings. The data was then analyzed using descriptive statistical analysis and inferential analysis. The experimental group scored better in writing, with a mean score of 77.20 compared to 73.70 for the control group, according to descriptive statistical analysis. Furthermore, based on hypothesis testing in inferential analysis, the computed t value = 2.112 (tobs) is greater than the t table value of 2.001 (tcv) with a standard alpha level (a = 0.05). As a result, the first hypothesis is rejected in favour of the alternate hypothesis. As a result, it can be determined that there is a significant difference in the learning accomplishment of class IX students when it comes to creating procedural texts utilizing the Wordwall application.
An Analysis of the Language Styles Used in Conversation between Craft Traders and Foreigners in Sukawati Market
Authors: Ketut Mitari Dewi
Published: October 2022

People will never use the same language to communicate because they have their own style. The way they choose the words or language style can be influenced by the setting of the conversation. Therefore, This study aims to analyze the style of language used by handicraft traders and foreign tourists in their conversation, the language style most often used, and the language function used by handicraft traders at the Sukawati market. This research was descriptive qualitative research. The subjects were two craft traders and twenty foreigners. Methods of collecting data by interview and observation. The research instrument was the researcher, observation sheet, interview, and voice recorder. The data analysis technique is descriptive qualitative analysis. The results of this study showed that the language styles used were the colloquial, casual, and consultative styles. From those styles, the consultative style was dominantly used by craft traders and foreigners. Moreover, the function of the language style used in the conversation was to persuade the foreigners to buy their merchandise, to make the speaker’s ideas clearer, to get foreigners’ attention, to create mood, and increase foreigners’ tastes or feeling.
HOTS-Based Worksheet in English Learning Activity for Eight Grade Students of Junior High School
Authors: Kenny Tirtayasa I Komang , Nitiasih Putu Kerti , Budiarta Luh Gd Rahayu
Published: October 2022

Teachers should be able to develop learning activities that offer meaningful learning to students and improve students' English skills. Higher Order Thinking Skills, or HOTS, are the current solution to support the development of student's abilities. This study has the purpose to develop a students' worksheet in a form of a supplementary book by promoting HOTS for eighth-grade students to implement curriculum 2013. The book is for the eighth grade in the second semester of junior high school students. This research implements D&D (Design and Development research) methods with four steps which are Analysis, Design, Development, and Evaluation. The researcher employed random sampling and participants in this study were eighth-grade Junior High School students. In collecting the data, the researcher conducted learning process observation, teacher interview, document analysis, and expert judgment. The result of the study found that the HOTS-Based Worksheet can use as a guide for leading and educating students when reading books. The use of this book makes learning more fun, interesting, and visually appealing for students. This worksheet can also help students improve their English language skills and critical thinking skills. The expert evaluation findings show that this product falls into the category of "very good" media. It is hoped that the product will be giving advantages for both students and teachers to improve the quality of English teaching and learning process.
E-LKPD Interaktif Berbasis Discovery Learning pada Muatan IPA Materi Ekosistem
Authors: Costadena Melinina Putri , Suniasih Ni Wayan
Published: October 2022

Pemanfaatan teknologi dalam penggunaan bahan ajar belum sepenuhnya optimal pada proses pembelajaran. Penelitian pengembangan ini bertujuan untuk menciptakan bahan ajar berupa E-LKPD interaktif berbasis discovery learning pada muatan IPA materi ekosistem kelas V SD. Penelitian pengembangan E-LKPD ini menggunakan model ADDIE. Metode pengumpulan data dalam penelitian pengembangan ini dengan melaksanakan observasi, wawancara, dan kuesioner. Subjek uji coba terdiri dari 1 ahli materi,1 ahli desain, 1 ahli media, uji coba perorangan 3 orang peserta didik, dan uji coba kelompok kecil 9 orang peserta didik Data tersebut dianalis secara deskriptif kuantitatif dan deskriptif kualitatif. Hasil penelitian review materi pembelajaran memperoleh persentase sebesar 91,6%, hasil review ahli desain pembelajaran memperoleh persentase sebesar 93,75%, hasil review ahli media pembelajaran memperoleh persentase sebesar 93,75%., uji coba perorangan memperoleh persentase sebesar 95%, dan uji coba kelompok kecil memperoleh persentase sebesar 95,31%. Persentase skor keseluruhan diperoleh dengan kualifikasi sangat baik sehingga E-LKPD interaktif berbasis discovery learning materi ekosistem layak digunakan untuk siswa kelas V SD. Implikasi penelitian ini diharapkan dapat membantu guru dalam pembelajaran daring untuk menjelaskan materi dan membantu siswa yang mengalami kesulitan memahami materi khususnya materi ekosistem.
Game Edukatif Berbasis Powerpoint untuk Mata Pelajaran IPS Kelas V Sekolah Dasar
Authors: Eveline Siregar  , Frista D. Ramadhani
Published: October 2022

Permasalahan dalam pelaksanaan kegiatan pembelajaran IPS adalah paradigma yang menunjukkan bahwa IPS merupakan salah satu pelajaran dengan materi yang padat, dan complex sehingga membuat kegiatan pembelajaran seringkali tidak menarik dan membosankan bagi siswa. Penelitian ini bertujuan untuk menghasilkan produk berupa game edukatif berbasis microsoft powerpoint sebagai media pembelajaran pendukung dalam kegiatan pembelajaran IPS bagi siswa kelas V SD. Jenis penelitian ini yaitu pengembangan dengan menggunakan model pengembangan DDD-E oleh Ivers dan Baron. Evaluasi pada penelitian pengembangan ini menggunakan evaluasi formatif yang terdiri dari expert review, one to one, small group. Subjek penelitian yaitu ahli media, ahli desain pembelajaran, serta dua ahli materi. Metode yang digunakan dalam mengumpulkan data yaitu observasi, wawancara, dan kuesioner. Instrumen yang digunakan dalam mengumpulkan data yaitu skala likert. Teknik analisis yang digunakan yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu game edukatif yang dikembangkan memiliki kualitas yang baik dan layak untuk digunakan sebagai media pembelajaran pendukung untuk mata pelajaran IPS bagi siswa kelas V Sekolah Dasar.
Pembelajaran Berbantuan Video Model Latihan Renang Gaya Bebas Terhadap Penguasaan Gaya Bebas dan Kecepatan Renang Siswa Sekolah Dasar
Authors: Dharma Sanjaya Pande Made , Rediani Ni Nyoman
Published: October 2022

Saat ini kondisi jam sekolah atlet berbenturan dengan jam penggunaan latihan, atlet yang kami miliki hampir semua bersekolah di sekolah negeri yang menerapkan jam sekolah full setengah hari dimana dimulai dari pagi hari yang rata-rata jam masuk sekolah pukul 07.00 Wita. Kemudian keluar sekolah pukul 15.30. belum lagi banyak orang tua yang memberikan pelajaran tambahan terhadap anaknya yang menyebabkan peserta didik mempunyai waktu yang singkat dalam berlatih renang menjadi alsan mengapa penelitian  yang bertujuan untuk menganalisis penggunaan pembelajaran berbatuan media video model latihan renang gaya bebas terhadap penguasaan gaya bebas dan kecepatan atlet sekolah dasar. Rancangan penelitian ini adalah quasi-eksperimental design berupa posstest control group design. jumlah populasi penelitian ini adalah 48. Proses pengumpulan data yang digunakan adalah metode tes dan dokumentasi. Metode analisis data penelitian ini adalah analisis deskriptif dan analisis statistik inferensial dengan manova. Hasil penelitian menunjukkan bahwa pembelajaran berbantuan video model latihan renang gaya bebas berpengaruh terhadap penguasaan renang gaya bebas dan kecepatan renang peserta didik baik secara simultan maupun parsial, hal ini ditunjukkan dnegan niali sig. < 0.05. Dari hasil deskritif data juga diperoleh hasil penelitian berupa variabel kecepatan peserta didik lebih dipengaruhi oleh pembelajaran berbasis youtube dibandingkan variabel pemahaman konsep. Sehingga bisa direkomendasikan bahwa pembelajaran berbantuan video model latihan renang gaya bebas bisa digunkan sebagai salah satu pembelajaran inovatif untuk olahraga renang.
Learning Media Innovation: Lift the Flap Book Digital in Increasing Interest in Learning Science for Third-Grade Elementary School Students
Authors: Bintoro Totok , Fahrurrozi  , Ika Lestari  , Febriani Rofiqoh
Published: October 2022

The The COVID-19 pandemic in Indonesia impacts all sectors, including the education sector. This pandemic has changed the use of face-to-face learning systems to online or distance learning. In this distance learning system, teachers are required to deliver learning materials well and pleasantly to students. This study aims to develop lift the flap book digital media to increase student interest in learning during the pandemic. This type of research is developed using the ADDIE method. The population of this study amounted to 24 students. The method used in data collection is observation, interviews, and questionnaires. The instrument used in data collection is a questionnaire sheet. The data analysis technique used to analyze the research data is descriptive qualitative and quantitative. The result of the analysis is that Lift The Flap Book's digital media received very good qualifications from experts to be suitable for use in learning. It was concluded that the media was very suitable for increasing the learning interest of third-grade elementary school students during the pandemic.
Development of Powerpoint-Based Interactive Media on Theme 8 Subtheme 1 in Elementary School
Authors: Nurkhodri Muhammad , Dafit Febrina
Published: October 2022

The use of media in learning in elementary schools is an important part that must receive attention from educators.  The use of interactive media is needed by elementary schools so that the learning provided becomes more effective and efficient. This study aims to develop interactive media based on powerpoint on the theme of 8 sub-theme 1 in class III of elementary school during offline learning activities. This research is a development research and uses the ADDIE model. The types of data taken from this development are qualitative data and quantitative data. The population of this research is third grade students. The trial conducted was a limited-scale trial with a sample of 6 students with different learning score categories. Data collection techniques consist of two types, namely the first teacher and student response questionnaire, second validation sheet material experts, media experts and linguists. Based on the results of research from media experts with a total of 93.33%, material experts with a total of 90.83% and linguists with a total of 90.94% and the overall results of 91.1% concluded that it is very valid to be used as a learning medium. The results of the analysis of teacher responses with a total of 94% and students with a total of 88.33% and the total results of 91.16% concluded that practical media were used in the learning process activities took place.
sistema CRISPR/Cas9 e o potencial para a talassemia beta
Authors: Serpeloni Beatriz Bonvicini , Oliveira Luíza Nayara Monção de , Damião Bruno , Peroni Luis Antonio , Simioni Patricia Ucelli
Published: October 2022

A Beta-talassemia major é uma hemoglobinopatia caracterizada por herança mendeliana haplo-insuficiente recessiva, sendo considerada a forma mais grave das talassemias, os portadores dependem de transfusões sanguíneas regulares e podem desenvolver problemas futuros, devido ao acúmulo de ferro ocasionado pelas transfusões. O objetivo do estudo é apresentar uma revisão e novos insights sobre o sistema CRISPR/Cas9 na edição de sequencias genéticas e sua potencial aplicação na terapia gênica para portadores de hemoglobinopatias, em especial a talassemia beta, que é caracterizada por desordens moleculares associada a deficiência acentuada da produção de cadeias beta da hemoglobina. Essa alteração reflete em uma síntese reduzida de hemoglobina que é tratada atualmente com transfusão sanguínea regular. O CRISPR associado a Cas9 e ao RNA guia, formam um complexo, capaz de reconhecer uma região específica do DNA e removê-la do genoma, esse sistema tem sido modelado por pesquisadores para atuar em sítios direcionados no DNA com o intuito de reparar genes mutados. A terapia gênica com o CRISPR/Cas9 para a talassemia beta, consiste em silenciar o gene BCL11A e estimular a produção de hemoglobina fetal, resultando em uma independência de transfusão sanguínea pelos portadores.
Pengaruh Pemberian Ekstrak Kecambah, Ekstrak Tomat dan Pupuk Cair Hayati pada Pertumbuhan Seedling Manggis (Garcinia mangostana L.)
Authors: Karyanto Agus , Pramono Sudi , Rugayah Rugayah , Fauzan Naufal Dani
Published: October 2022

The slow initial growth of mangosteen is caused by poor rooting, especially secondary roots and root hairs. Therefore, technology is needed to stimulate root growth so that the absorption of nutrients in the soil becomes effective. This study used mung bean sprout extracts and tomato extracts as natural plant growth regulators (PGRs) combined with the use of biological liquid fertilizers. This research was conducted in the greenhouse of the Horticulture Building, Department of Agronomy and Horticulture, Faculty of Agriculture, University of Lampung from March 2020 to July 2020. The treatments were arranged in a factorial (3x2) in a randomized block design which was repeated 3 times. The first factor was natural PGR, which consists of: without natural PGR, mung bean sprout extract, and a mixture of sprout and tomato extract. The second factor was biological liquid fertilizer,  which consists of control and with biological liquid fertilizer. The homogeneity of variance was tested by the Bartlett test, while the data additivity test was tested by the Tukey test. If the assumptions were met, the data was then analyzed by means of variance. The difference in the mean value was tested with LSD at the 5% level. The results showed that the administration of natural PGRs and biological liquid fertilizer did not show a significant effect on all the variables tested. The growth of most seedlings were upnormal due to the presence of root-attacking insect larvae previosuly present in the growing media. With minor disturbance from insect, the control plants showed better plant height (1.85 cm), number of leaves (3.28 pieces), leaf area (15.21 cm2), primary root length ( 3.77 cm), the number of secondary roots (2 strands), and plant fresh weight (3.55 g) than the treatments.  Keywords         : biological liquid fertilizer,  mangosteen, natural PGR