bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of obesity profiles and metabolic health status with liver injury among US adult population in NHANES 1999–2016
Authors: Huang Jing , Gao Tian , Zhang Huinan , Wang Xing
Published: September 2023

The combined effect of obesity and metabolic abnormalities on liver injury is unclear. Aiming to address this knowledge gap, this cross-sectional study was conducted among 16,201 US adults. Multiple linear regression and logistic regression analyses were conducted to assess the associations of obesity profiles, metabolic health status, and weight change with the levels of liver enzymes. The analysis revealed that general obesity and abdominal obesity were positively associated with the levels of liver enzymes and the prevalence of abnormal liver enzymes (PandPtrend < 0.05). The associations remained significant in both metabolically healthy and metabolically unhealthy subgroups. Additionally, the liver injury index levels of the metabolically unhealthy participants were higher than those of the metabolically healthy individuals within the non-obese, overweight/pre-abdominal obesity, and general/abdominal obesity subgroups (PandPtrend < 0.05). Furthermore, the subgroup characterized by general/abdominal obesity and metabolic dysfunction exhibited the most robust association with the liver injury index compared to all other subgroups examined. In addition, positive associations were observed between the 1-year and 10-year weight changes and the levels of liver injury indicators (PandPtrend < 0.05). In conclusion, this study demonstrates that both obesity and metabolic impairment are independently associated with liver injury, and their combined presence have an additional adverse effect on liver health. These findings underscore the importance of addressing both obesity and metabolic dysfunction in order to mitigate the risk of liver injury.
MYC–MAX heterodimerization is essential for the induction of major zygotic genome activation and subsequent preimplantation development
Authors: Yamamoto Takuto , Wang Haoxue , Sato Hana , Honda Shinnosuke , Ikeda Shuntaro , Minami Naojiro
Published: September 2023

In mouse preimplantation development, zygotic genome activation (ZGA), which synthesizes new transcripts in the embryo, begins in the S phase at the one-cell stage, with major ZGA occurring especially at the late two-cell stage. Myc is a transcription factor expressed in parallel with ZGA, but its direct association with major ZGA has not been clarified. In this study, we found that developmental arrest occurs at the two-cell stage when mouse embryos were treated with antisense oligonucleotides targeting Myc or MYC-specific inhibitors from the one-cell stage. To identify when MYC inhibition affects development, we applied time-limited inhibitor treatment and found that inhibition of MYC at the one-cell, four-cell, and morula stages had no effect on preimplantation development, whereas inhibitor treatment at the two-cell stage arrested development at the two-cell stage. Furthermore, transcriptome analysis revealed that when MYC function was inhibited, genes expressed in the major ZGA phase were suppressed. These results suggest that MYC is essential for the induction of major ZGA and subsequent preimplantation development. Revealing the function of MYC in preimplantation development is expected to contribute to advances in assisted reproductive technology.
Beam-steering of dielectric flat lens nanoantenna with elliptical patch based on antenna displacement for optical wireless applications
Authors: Helmy Fatma E. , Ibrahim Ibrahim I. , Saleh Amany M.
Published: September 2023

In this paper, the switched-beam nanoantenna (NA) concept is introduced with a theoretical design of an inhomogeneous dielectric flat lens modelled with different materials to steer and enhance the radiation in a particular direction based on shifting the illuminator element. Firstly, the design of hybrid plasmonic NA is introduced and analyzed considering different silicon patch shapes such as rectangular, circular, hexagonal, and elliptical shapes. The elliptical patch NA achieves a gain of up to 10.7 dBi and a return loss of − 14.41 dB. Then the design of a gradient-index dielectric flat lens with the NA is introduced to improve the antenna performance by increasing the directivity and consequently decreasing the beam-width. Furthermore, the beam-steering capabilities by displacement of the NA according to different feeding points along the X and Y-direction. By using the gradient-index dielectric flat lens, the gain is increased to 18.4 dBi with an improvement in the return loss reach to − 19.15 dB compared with traditional NA. In addition, the beam-steering capabilities were achieved with a range ± 60° ×  ± 55° with acceptable average antenna gain, side-lobe levels, and half power beam-width of 16.5 dBi, − 12.3 dB and 13.6° respectively.
Impact of negative links on the structural balance of brain functional network during emotion processing
Authors: Soleymani Farhad , Khosrowabadi Reza , Pedram Mir Mohsen , Hatami Javad
Published: September 2023

Activation of specific brain areas and synchrony between them has a major role in process of emotions. Nevertheless, impact of anti-synchrony (negative links) in this process still requires to be understood. In this study, we hypothesized that quantity and topology of negative links could influence a network stability by changing of quality of its triadic associations. Therefore, a group of healthy participants were exposed to pleasant and unpleasant images while their brain responses were recorded. Subsequently, functional connectivity networks were estimated and quantity of negative links, balanced and imbalanced triads, tendency to make negative hubs, and balance energy levels of two conditions were compared. The findings indicated that perception of pleasant stimuli was associated with higher amount of negative links with a lower tendency to make a hub in theta band; while the opposite scenario was observed in beta band. It was accompanied with smaller number of imbalanced triads and more stable network in theta band, and smaller number of balanced triads and less stable network in beta band. The findings highlighted that inter regional communications require less changes to receive new information from unpleasant stimuli, although by decrement in beta band stability prepares the network for the upcoming events.
Association between SLCO1B1 genetic polymorphisms and bleeding risk in patients treated with edoxaban
Authors: Han Ji Min , Jang Eun Jeong , Yee Jeong , Song Tae-Jin , Kim Dong-Hyeok , Park Junbeom , Gwak Hye Sun
Published: September 2023

Since SLCO1B1 encodes the uptake transporter OATP1B1, which can influence the pharmacokinetic and pharmacodynamic profiles of edoxaban, polymorphisms in SLCO1B1 may affect the edoxaban response. This study aimed to investigate the association between SLCO1B1 gene polymorphisms and the bleeding risk in patients receiving edoxaban. We genotyped 10 single-nucleotide polymorphisms (SNPs) from the SLCO1B1 gene in patients receiving edoxaban. We also analyzed rs3842 of ABCB1 as a confounder. The odds ratio (OR) and adjusted OR (AOR) were calculated from univariate and multivariable analysis, respectively. The area under the receiver operating characteristic curve (AUROC) was constructed for the discrimination of the model. A total of 159 patients receiving edoxaban were analyzed. Overdose and rs4149056 showed significant association with bleeding complications by around 11- and 5.5-fold, respectively. Additionally, patients with the rs4149057 variant allele (C) had a 3.9-fold increased bleeding risk compared with wild-type homozygote carriers (TT), whereas rs2306283 variant homozygote (GG) carriers had a 0.27-fold reduced bleeding risk compared with wild-type allele (A) carriers. Patients with the variant-type homozygote (CC) of ABCB1 rs3842 had a higher bleeding risk than T allele carriers (AOR = 5.3 and 5.9). The final models for multivariable analyses were acceptable based on the AUROC values (> 0.70). These findings may help predict bleeding risk in patients taking edoxaban and help personalize treatment.
Strain-induced degradation and recovery of flexible NbOx-based threshold switching device
Authors: Ang Jia Min , Dananjaya Putu Andhita , Ang Calvin Ching Ian , Lim Gerard Joseph , Lew Wen Siang
Published: September 2023

We investigate the functionality of NbOx-based selector devices on a flexible substrate. It was observed that the failure mechanism of cyclic tensile strain is from the disruption of atom arrangements, which essentially led to the crack formation of the film. When under cyclic compressive strain, buckling delamination of the film occurs as the compressed films have debonded from their neighboring layers. By implementing an annealing process after the strain-induced degradation, recovery of the device is observed with reduced threshold and hold voltages. The physical mechanism of the device is investigated through Poole–Frenkel mechanism fitting, which provides insights into the switching behavior after mechanical strain and annealing process. The result demonstrates the potential of the NbOxdevice in flexible electronics applications with a high endurance of up to 105cycles of cyclic bending strain and the recovery of the device after degradation.
Optimization of combustion organization scheme for pre-combustion chamber of pre-cooled engine
Authors: Yu Nanjia , Jiao Bowei , Zhou Chuang , Han Shutao , Li Tianwen , Shi Haoran
Published: September 2023

Pre-cooled engines, in which the incoming air is cooled by a pre-cooler before it enters the subsequent components for operation, are one of the important developments in combined power solutions. Therefore, how to optimize the gas temperature uniformity of the high temperature gas stream at the outlet of the pre-combustion chamber to achieve higher efficiency of the pre-cooled engine will be the main research content. In this paper, grid partitioning was performed on the pre combustion chamber model, and the k-omega model and EDC model were used to simulate the internal flow field of the pre combustion chamber. And verify the correctness of the simulation through engine hot testing. Explored the changing trends of the internal velocity and temperature fields of the engine under different secondary injection structures. The larger the secondary injection flow rate, the more obvious the obstruction to high-temperature gas, and the better the uniformity of gas temperature. However, in experiments, the secondary injection components often cannot withstand a large flow rate ratio. Ultimately, the gas temperature uniformity is best when the secondary injection flow rate ratio is 65%. Circumferential deflection will cause the gas to spin, and the spinning process will make the gas temperature at the same radius more uniform. However, due to the decrease in radial velocity, the obstruction effect on the overall high-temperature gas is weakened. When the gas is deflected towards the head by 30°, the velocity of the incoming gas and the velocity of the secondary injection gas are combined and perpendicular to the axis. At this time, the gas temperature uniformity is the best.
Structural analysis and ionic conduction mechanism of sulfide-based solid electrolytes doped with Br
Authors: Yamaguchi Hiroshi , Kobayashi Kentaro , Hiroi Satoshi , Utsuno Futoshi , Ohara Koji
Published: September 2023

Sulfide glasses can exhibit notable ionic conductivity because of annealing-associated crystallization. One well-known example is Li7P3S11. Our research showed that adding bromine (Br) to Li3PS4 sulfide glass results in a similar crystal structure and high ionic conductivity comparable to that of another compound Li10GeP2S12. This structure differs from the PS4 anion framework of Li3PS4. In addition, the ionic conductivity decreases owing to a structural transition to the β-phase. Herein, we present our findings on the local structure of Li3PS4 sulfide glass and its crystallized glass ceramic with the addition of Br. This analysis relies on the pair distribution function analysis obtained from high-energy X-ray diffraction. Moreover, using the bond valence sum method, we verified that incorporating Br promotes the formation of Li ionic conduction pathways. Our results indicate that precise control over the anion molecular structure by introducing halogens holds promise for achieving high Li-ion conductivity.
Association between endothelin-1 and systemic lupus erythematosus: insights from a case–control study
Authors: Li Rong , Yang Chan , Tang Yang-Yang , Wang Da-Cheng , Xu Wang-Dong , Huang An-Fang
Published: September 2023

Systemic lupus erythematosus (SLE) is a chronic rheumatic disorder. Endothelin-1, a vasoconstrictor, belongs to the endothelin family and is associated with vascular-related damages. To date, association between ET-1 and pathogenesis of SLE remains unclear. This case–control study was carried out by 314 SLE, 252 non-SLE diseases patients and 500 healthy controls. Serum ET-1, CCN3, IL-28B levels were detected by ELISA, and ET-1 gene polymorphisms (rs5369, rs5370, rs1476046, rs2070699, rs2071942, rs2071943, rs3087459, rs4145451, rs6458155, rs9369217) were genotyped with Kompetitive Allele-Specific PCR. SLE patients had high levels of ET-1, which were correlated with some clinical, laboratory features. Serum CCN3, IL-28B levels were higher in SLE patients, and ET-1 levels were positively correlated with the two cytokines. Rs5370, rs1476046, rs2070699, rs2071942, rs2071943, rs3087459, rs6458155 and rs2070699 were associated with SLE risk. Rs2070699 (T, TT) was related to SLE patients with alopecia. Rs5370 (T, TT, TG), rs1476046 (G,GA), rs2071942 (G,GA) and rs2071943 (G,GA) were associated with SLE patients with pericarditis, pyuria and fever manifestation, respectively. Rs3087459 (CC) and rs9369217 (TC) were related to SLE patients with positive anti-SSB antibody. Rs5369 (AA) was associated with IgG and CRP levels in SLE patients. In conclusion, elevated serum ET-1 in SLE patients may be a potential disease marker, and its gene polymorphisms were related to SLE susceptibility.
New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders
Authors: Cros Maria Pol , Mir-Pedrol Júlia , Toloza Lorena , Knödlseder Nastassia , Maruotti Julien , Zouboulis Christos C. , Güell Marc , Fábrega Maria-José
Published: September 2023

Cutibacterium acnes (C. acnes) is one of the most prevalent bacteria that forms the human skin microbiota. Specific phylotypes of C. acnes have been associated with the development of acne vulgaris, while other phylotypes have been linked to healthy skin. In this scenario, bacterial extracellular vesicles (EVs) play a role in the interkingdom communication with the human host. The purpose of this study was to examine the impact of EVs generated by various phylotypes of C. acnes on inflammation and sebum production using different in vitro skin cell types. The main findings of this study reveal that the proteomic profile of the cargo embodied in the EVs reflects distinct characteristics of the different C. acnes phylotypes in terms of life cycle, survival, and virulence. The in vitro skin cell types showed an extended pro-inflammatory modulation of SLST A1 EVs consistently triggering the activation of the inflammation-related factors IL-8, IL-6, TNFα and GM-CSF, in comparison to SLST H1 and SLST H2. Additionally, an acne-prone skin model utilizing PCi-SEB and arachidonic acid as a sebum inducer, was employed to investigate the impact of C. acnes EVs on sebum regulation. Our findings indicated that all three types of EVs significantly inhibited sebum production after a 24-h treatment period, with SLST H1 EVs exhibiting the most pronounced inhibitory effect when compared to the positive control. The results of this study highlight the protective nature of C. acnes SLST H1 EVs and their potential use as a natural treatment option for alleviating symptoms associated with inflammation and oily skin.
Dynamic gravitational excitation of structural resonances in the hertz regime using two rotating bars
Authors: Tobias Brack , Jonas Fankhauser , Bernhard Zybach , Fadoua Balabdaoui , Stephan Kaufmann , Francesco Palmegiano , Jean-Claude Tomasina , Stefan Blunier , Donat Scheiwiller , Jürg Dual
Published: September 2023

With the planning of new ambitious gravitational wave observatories, fully controlled laboratory experiments on dynamic gravitation become more and more important. Such experiments can provide new insights in potential dynamic effects such as gravitational shielding or energy flow and might contribute to bringing light into the mystery still surrounding gravity. Here we present a laboratory-based transmitter-detector experiment using two rotating bars as transmitter and a 42 Hz, high-Q bending beam resonator as detector. Using a precise phase control to synchronize the rotating bars, a dynamic gravitational field emerges that excites the bending motion with amplitudes up to 100 nm/s or 370 pm, which is a factor of 500 above the thermal noise. The two-bar design enables the investigation of different transmitter configurations. The detector movement is measured optically, using three commercial interferometers. Acoustical, mechanical, and electrical isolation, a temperature-stable environment, and lock-in detection are central elements of the setup. The moving load response of the detector is numerically calculated based on Newton’s law of gravitation via discrete volume integration, showing excellent agreement between measurement and theory both in amplitude and phase. The near field gravitational energy transfer is 1025 times larger than the one of the propagating gravitational wave component.
Reactive X (where X = O, N, S, C, Cl, Br, and I) species nanomedicine
Authors: Wang Keyi , Mao Weipu , Song Xinran , Chen Ming , Feng Wei , Peng Bo , Chen Yu
Published: September 2023

Reactive oxygen, nitrogen, sulfur, carbonyl, chlorine, bromine, and iodine species (RXS, X = O, N, S, C, Cl, Br, and I) play important roles in normal physiological processes through governing cell signaling, immune balance, and tissue homeostasis.
Twisted [C2O5]2−-groups in Ba[C2O5] pyrocarbonate
Authors: Spahr Dominik , Bayarjargal Lkhamsuren , Haussühl Eiken , Luchitskaia Rita , Friedrich Alexandra , Milman Victor , Fedotenko Timofey , Winkler Björn
Published: September 2023

Ba[C2O5] was synthesized by reacting Ba[CO3] with CO2 and contains twisted [C2O5]2−-groups, an atomic arrangement previously not observed in carbonates.
Boosting the methanol selectivity in CO2 hydrogenation over a MOF-derived CuZn@CN catalyst via Rb incorporation
Authors: Gahtori Jyoti , Kaishyop Jyotishman , Singh Gaje , Khan Tuhin S. , Vicentin Flavio C. , Rocha Tulio C.R. , Bordoloi Ankur
Published: September 2023

The highly selective hydrogenation of CO2 to methanol has been achieved through the simultaneous utilization of alkali metals and Co as promoters over Cu–Zn@CN catalysts derived from MOF.
Ruthenium-catalysed cross-coupling reaction of ketones with transformable directing groups as alkenyl electrophiles
Authors: Kogure Yuya , Hatakeyama Kohei , Tsuchiya Kai , Kunii Yuta , Ueno Satoshi
Published: September 2023

Novel ruthenium-catalysed cross-coupling of β-ketoamides as alkenyl electrophiles with organoboronates was developed. The reaction proceeds via the cleavage of the alkenyl C–N bond of the in situ generated β-enaminoamide.
Progress in controllable bioorthogonal catalysis for prodrug activation
Authors: Liu Xia , Huang Tingjing , Chen Zhaowei , Yang Huanghao
Published: September 2023

This Feature Article summarizes the recent progress in prodrug activation mediated by controllable bioorthogonal catalysis.
Unusual similarity of DNA solvation dynamics in high-salinity crowding with divalent cations of varying concentrations
Authors: Sardana Deepika , Alam Parvez , Yadav Kavita , Clovis Ndege Simisi , Kumar Pramod , Sen Sobhan
Published: September 2023

Even amidst hypersaline conditions with divalent cation crowding, slow solvation dynamics in DNA remain unusually similar, though DNA stability and ligand binding affinity to DNA are affected drastically by the ion-crowding.
A tunable infrared emitter based on phase-changing material GST for visible-infrared compatible camouflage with thermal management
Authors: Kang Qianlong , Guo Kai , Guo Zhongyi
Published: September 2023

In this paper, we propose a tunable infrared emitter composed of ZnS/Ge/Ag/Ge2Sb2Te5/Ag films and numerically demonstrate visible-infrared compatible camouflage and radiation heat dissipation.
Electronic structure and energetics of a heterodimeric BChlg′/Chla′ special pair generated by exposure ofHeliomicrobium modesticaldumto dioxygen
Authors: Kaur Divya , Ferlez Bryan , Landry Patrick , Biskup Till , Weber Stefan , Golbeck John H. , Lakshmi K. V. , van der Est Art
Published: September 2023

Exposure of Heliobacteria to dioxygen generates a functional heterodimeric special pair in which the hole density is localized on bacteriochlorophyllg′.
Electrical surface properties of nanoporous alumina membranes: influence of nanochannels’ curvature, roughness and composition studied via electrokinetic experiments
Authors: Vakilinejad Ali , Dubois Emmanuelle , Michot Laurent , Jardat Marie , Lairez Didier , Durand-Vidal Serge , Guibert Clément , Jouault Nicolas
Published: September 2023

The combination of several electrokinetic techniques on different surfaces of AAO membranes reveals differences in IEPs that presumably originate from the variation of the coordination number of aluminum atoms depending on the probed surface.
The entropy-controlled strategy in self-assembling systems
Authors: Zhang Xuanyu , Dai Xiaobin , Gao Lijuan , Xu Duo , Wan Haixiao , Wang Yuming , Yan Li-Tang
Published: September 2023

The entropy-controlled strategy of self-assembly offers a conceptually new way to tune the ordering transitions in the development of designer systems and materials with controllable structures and optimal properties.
Preparation of Ru-doped Cu-based catalysts for enhanced electrochemical ammonia synthesis from efficient electrocatalytic nitrate reduction
Authors: Liu Anmin , Li Guangxin , Cao Jianghui , Zhao Fang , Chen Xiru , Hua Qianqian , Gao Liguo , Ma Tingli , Ren Xuefeng
Published: September 2023

Cu/Cu2O/RuO2@C composites prepared by the NITRR reached an NH3 yield of 209.44 μmol cm−2 h−1 and 82.40% Faraday efficiency at −0.6 V (vs. RHE).
A novel SnIn4S8/ZnFe2O4 S-scheme heterojunction with excellent magnetic properties and photocatalytic degradation activity for tetracycline
Authors: Zhang Dafeng , Zhang Ruiqi , Jiang Xue , Zhang Dong , Li Hengshuai , Liu Junchang , Pu Xipeng , Cai Peiqing
Published: September 2023

The development of efficient and economical photocatalysts is considered a promising strategy for pollution remediation.
In silico identification of novel PqsD inhibitors: promising molecules for quorum sensing interference in Pseudomonas aeruginosa
Authors: Vieira Tatiana F. , Cerqueira Nuno M. F. S. A. , Simões Manuel , Sousa Sérgio F.
Published: September 2023

PqsD is an anthraniloyl-CoA anthraniloyltransferase involved in the synthesis of the secondary metabolites essential to the formation of Pseudomonas quinolone signal (PQS) inducer molecules.
A review of catalytic oxidation of carbon monoxide over different catalysts with an emphasis on hopcalite catalysts
Authors: Ngorot Kembo Jellinette Pulcira , Wang Junyi , Luo Ning , Gao Fengyu , Yi Honghong , Zhao Shunzheng , Zhou Yuansong , Tang Xiaolong
Published: September 2023

Hopcalite catalysts are reviewed showing highly active catalysts for low-temperature, low-cost and complete oxidation of CO.
Self-assembled peptide-based nanoblocks for drug delivery
Authors: Xie Xiaoming , Meng Fanrui , Zhang Zilin , Xu Xingyu , Guo Minmin , Jiang Yulian , Wang Ting
Published: September 2023

Novel nanoblocks based on peptide assembly for drug delivery.
Regulating the iodine adsorption performances of two- and three-component β-ketoenamine-linked covalent organic frameworks through tuning the proportion of monomers
Authors: Wen Yu-Yang , Dong Zhao-Yi , Tang Xi-Hao , Zhang Wei-Guang , Cai Song-Liang , Fan Jun
Published: September 2023

The crystallinity, specific surface area, and amino content of NH2-ThX-Mth1−X-Tfp COFs have been effectively regulated by changing the mole ratio of NH2-Th and Mth. Interestingly, they showed different iodine vapour capture performances.
A multimodal therapeutic nano-prodrug as an oxidative stress amplifier induces apoptosis and ferroptosis for cancer therapy
Authors: Wang Zining , Liu Min , Hu Jinzhong , Wei Wanying , Chen Fanghui , Sun Baiwang
Published: September 2023

Schematic illustration of the construction process of MDTFH and its antitumor effects via PTT/CT/CDT synergy for apoptosis/ferroptosis induction.
Reactive adsorption of NO2 over the NaCoO2–Co3O4 nanocomposite: experimental study and first-principles calculations
Authors: Gupta Nishesh Kumar , Rajput Kaptan , Mehta Bijal R. , Viltres Herlys , Roy Debesh R. , Kim Kwang Soo
Published: September 2023

Room-temperature oxidation of NO2 gas (100 ppm) over a MOF-derived NaCoO2–Co3O4 nanocomposite.
Conjugated coupler curvature enhances magnetic spin coupling in π-diradicals
Authors: Yu Shaofen , Song Yamin , Bu Yuxiang , Song Xinyu
Published: September 2023

This work computationally evidences that the functionalized buckybowls as the couplers can considerably enhance the magnetic spin coupling interaction in π-diradicals through curving the coupler to reduce its aromaticity and increase spin polarization of radical groups.
Embracing the era of antimicrobial peptides with marine organisms
Authors: Chen Pengyu , Ye Ting , Li Chunyuan , Praveen Praveen , Hu Zhangli , Li Wenyi , Shang Chenjing
Published: September 2023

The marine world is a rich reservoir for the discovery of antimicrobial peptides, namely antibiotic alternatives. The current review summarized the most recently identified AMPs, with a focus on exploiting the PTMs for mature AMP production.
Synthesis of NMN by cascade catalysis of intracellular multiple enzymes
Authors: Hua Wenfeng , Jiang Na , Wu Yifei , Zhou Cailian , Chen Kequan , Wang Xin
Published: September 2023

Three multi-enzyme cascade catalytic pathways were constructed to explore the supply capacity of glucose, xylose, and arabinose to PRPP. 1.8 mM NMN was ultimately produced under optimized conditions using glucose as the substrate.
Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
Authors: Bukhari Syed Nasir Abbas , Alsahli Tariq G. , Ejaz Hasan , Ahmed Naveed , Ahmad Waqas , Elsherif Mervat A. , Alotaibi Nasser H. , Junaid Kashaf , Janković Nenad
Published: September 2023

The arylidene indolin-2-ones showed significant dual biological activity against MCF-T cancer cell lines and Candida species. The most promising molecule for further investigation contains an m-aminophenyl fragment.
TPN-COF@Fe-MIL-100 composite used as an electrochemical aptasensor for detection of trace tetracycline residues
Authors: Meng Yubo , Huang Yuchun , Huang Gailing , Song Yingpan
Published: September 2023

TPN-COF@Fe-MIL-100 was used to construct an aptasensor for detecting tetracycline. A low detection limit of 1.227 fg mL−1 within 0.01–10000 pg mL−1 is deduced. High selectivity, reproducibility, stability, regenerability, and applicability are obtained.
Correction: Influence of Ni content on structural, magnetocaloric and electrical properties in manganite La0.6Ba0.2Sr0.2Mn1−xNixO3 (0 ≤ x ≤ 0.1) type perovskites
Authors: Dhahri Ahmed , Laifi J. , Gouadria Soumaya , Elhadi M. , Dhahri E. , Hlil E. K.
Published: September 2023

Correction for ‘Influence of Ni content on structural, magnetocaloric and electrical properties in manganite La0.6Ba0.2Sr0.2Mn1−xNixO3 (0 ≤ x ≤ 0.1) type perovskites’ by Ahmed Dhahri et al., RSC Adv., 2022, 12, 3935–3947, https://doi.org/10.1039/d1ra07059b.
Wrinkling composite sheets
Authors: Suñé Marc , Arratia Cristóbal , Bonfils A. F. , Vella Dominic , Wettlaufer J. S.
Published: September 2023

We examine the buckling shape and critical compression of confined inhomogeneous composite sheets lying on a liquid foundation.
Identification and functional characterization of novel plant UDP-glycosyltransferase (LbUGT72B10) for the bioremediation of 3,4-dichloroaniline
Authors: Della Gala Valeria , Welner Ditte Hededam
Published: September 2023

LbUGT72B10 from Lycium barbarum is an efficient enzyme in catalyzing the N-glycosylation of the persistent pollutant 3,4-DCA. Its notable stability makes it a promising biocatalyst for potential use in bioremediation efforts aimed at recovering contaminated environments.
Reinforcing ionic conductivity and alleviating dendrite propagation of dense cubic Ga0.3Li6.1La3Zr2O12via two-step sintering
Authors: Lee Rae-Hyun , Sim Jae-Won , Lee Jong-Kyu , Oh Hyeong-Seok , Yoon Jung-Rag , Kim Kyong-Nam , Lee Seung-Hwan
Published: September 2023

Garnet-type Li7La3Zr2O12 (LLZO) has emerged as a promising candidate to supersede the liquid electrolytes in lithium-ion batteries.
In situ formed copper nanoparticles via strong electronic interaction with organic skeleton for pH-universal electrocatalytic CO2 reduction
Authors: Zhang Ying , Zhang Chenchen , Wang Dan , Gui Jianing , Mao Junjun , Lou Yang , Pan Chengsi , Zhu Yongfa
Published: September 2023

Electrochemical CO2 reduction reaction (CO2RR) has mainly been implemented in alkaline and neutral electrolytes. In this work, we report an in situ formed novel organic/inorganic copper hybrid catalyst, which is an efficient catalyst for CO2RR in pH-universal electrolytes.
1D/2D NiFeP/NiFe–OH heterostructure: roles of the unique nanostructure in stabilizing highly efficient oxygen evolution reaction
Authors: Zhao Fuzhen , Zheng Xin , Mao Xinyu , Liu Huicong , Zhu Liqun , Li Weiping , Ye Hui , Chen Haining
Published: September 2023

The 1D/2D NiFeP/NiFe–OH catalyst could not only rapidly release O2 bubbles during OER operation, but also suppress Fe dissolution from the 1D NTs by the 2D outer shells, tending to form stable NiFeP/NiOOH heterostructures eventually.
Development of tris(amino)phosphonium electrolytes for high performing sodium batteries
Authors: Sun Ju , Kang Colin S. M. , Huang Gongyue , Vallana Federico Maria Ferrero , Kumar Ajit , O'Dell Luke A. , Galceran Montserrat , Hutt Oliver , Howlett Patrick C. , Forsyth Maria , Pringle Jennifer M.
Published: September 2023

A unique family of salts utilising the new tris(amino)phosphonium cation [P1(DEA)3]+, paired with [FSI]− anions, supports stable Na plating/stripping with a small overpotential and non-dendritic morphology.
Advances and challenges in membrane electrode assembly electrolyzers for CO2 reduction
Authors: Ye Qingqing , Zhao Xueyang , Jin Ruiben , Dong Fan , Xie Hongtao , Deng Bangwei
Published: September 2023

This review emphasizes the fundamentals of MEA construction, different technical routes, and remaining challenges and opportunities for MEA for large-scale electrochemical CO2 reduction applications.
Air-stable bismuth sulfobromide (BiSBr) visible-light absorbers: optoelectronic properties and potential for energy harvesting
Authors: Guo Xiaoyu , Huang Yi-Teng , Lohan Hugh , Ye Junzhi , Lin Yuanbao , Lim Juhwan , Gauriot Nicolas , Zelewski Szymon J. , Darvill Daniel , Zhu Huimin , Rao Akshay , McCulloch Iain , Hoye Robert L. Z.
Published: September 2023

Phase-pure thin films of BiSBr are shown to have an optical efficiency limit of 43.6% under indoor lighting, with improved environmental and photo-stability over lead-halide perovskites, and have band positions well suited to a range of charge transport layer materials.
Metal–organic frameworks and covalent organic frameworks as photocatalysts for H2O2 production from oxygen and water
Authors: Sun Jiamin , Chakraborty Jeet , Deng Maojun , Laemont Andreas , Feng Xiao , Liu Ying-Ya , Van Der Voort Pascal
Published: September 2023

This review provides a detailed overview of the application of MOFs and COFs for photocatalytic H2O2 production from O2 and/or H2O.
Floating zone crystal growth, structure, and properties of a cubic Li5.5La3Nb1.5Zr0.5O12 garnet-type lithium-ion conductor
Authors: Ramette Caleb , Pressley Lucas , Avdeev Maxim , Lee Minseong , Kushwaha Satya , Krogstad Matthew , Sarker Suchismita , Cardon Paul , Ruff Jacob , Khan Mojammel , Kataoka Kunimitsu , McQueen Tyrel , Ji Huiwen
Published: September 2023

Floating zone growth of a cm-sized solid-state electrolyte single crystal, identification of two distinct Li sites with Laue neutron diffraction, and Li-ion conductivity and migration energy determination by EIS and dielectric measurements.
A hydrophobic–superoleophilic 2D Zr-based alkyne-rich metal–organic framework for oil/water separation and solar-assisted oil evaporation
Authors: Luo Qian-Ru , Zhong Yuan-Hui , Chung Lai-Hon , Jiang Zhixin , Lin Qia-Chun , Xu Xin-Ke , Ye Xinhe , Liao Wei-Ming , He Jun
Published: September 2023

A hydrophobic/superoleophilic spongy composite based on alkyne-rich 2D Zr-MOF and polyurethane executes solar-assisted self-cleaning oil/water separation.
ortho O-Annulated azabenzannulated perylenediimide and bisazacoronenediimide
Authors: David Arthur H. G. , Shymon Daryna , Melville Hayley , Accou Lou-Ann , Gapin Adèle , Allain Magali , Alévêque Olivier , Force Maximilien , Grosjean Alexis , Hudhomme Piétrick , Le Bras Laura , Goujon Antoine
Published: September 2023

The synthesis of electron-deficient ortho O-annulated bisazacoronenediimides is reported. Their preliminary results in devices, strong light absorption and flat structure make them a new interesting scaffold for the design of electron acceptors.
Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity
Authors: Zhang Qi , Tretyakova Natalia
Published: September 2023

Inosine, a purine nucleoside containing the hypoxanthine (HX) nucleobase, can form in DNA via hydrolytic deamination of adenine. Due to its structural similarity to guanine and the geometry of Watson–Crick base pairs, inosine can mispair with cytosine upon catalysis by DNA polymerases, leading to AT → GC mutations. Additionally, inosine plays an essential role in purine nucleotide biosynthesis, and inosine triphosphate is present in living cells. In a recent publication, Averill and Jung examined the possibility of polη catalyzed incorporation of deoxyinosine triphosphate (dITP) across dC and dT in a DNA template. They found that dITP can be incorporated across C or T, with the ratio of 13.7. X ray crystallography studies revealed that the mutagenic incorporation of dITP by human polη was affected by several factors including base pair geometry in the active site of the polymerase, tautomerization of nucleobases, and the interaction of the incoming dITP nucleotide with active site residues of polη. This study demonstrates that TLS incorporation of inosine monophosphate (IMP) into growing DNA chains contributes to its mutagenic potential in cells.
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex
Authors: Hagiwara Takumi , Minami Ryosuke , Ushio Chizuru , Yokota Naoto , Kawahara Hiroyuki
Published: September 2023

Inclusion body formation is associated with cytotoxicity in a number of neurodegenerative diseases. However, the molecular basis of the toxicity caused by the accumulation of aggregation-prone proteins remains controversial. In this study, we found that disease-associated inclusions induced by elongated polyglutamine chains disrupt the complex formation of BAG6 with UBL4A, a mammalian homologue of yeast Get5. UBL4A also dissociated from BAG6 in response to proteotoxic stresses such as proteasomal inhibition and mitochondrial depolarization. These findings imply that the cytotoxicity of pathological protein aggregates might be attributed in part to disruption of the BAG6–UBL4A complex that is required for the biogenesis of tail-anchored proteins.
Colchicine protects against the development of experimental abdominal aortic aneurysm
Authors: Zhao Yi , Shen Qi-Rui , Chen Yu-Xin , Shi Yu , Wu Wen-Bing , Li Qiao , Li Dong-Jie , Shen Fu-Ming , Fu Hui
Published: September 2023

Abdominal aortic aneurysm (AAA) is characterized by at least 1.5-fold enlargement of the infrarenal aorta, a ruptured AAA is life-threatening. Colchicine is a medicine used to treat gout and familial Mediterranean fever, and recently, it was approved to reduce the risk of cardiovascular events in adult patients with established atherosclerotic disease. With an AAA mice model created by treatment with porcine pancreatic elastase (PPE) and β-aminopropionitrile (BAPN), this work was designed to explore whether colchicine could protect against the development of AAA. Here, we showed that colchicine could limit AAA formation, as evidenced by the decreased total aortic weight per body weight, AAA incidence, maximal abdominal aortic diameter and collagen deposition. We also found that colchicine could prevent the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally, it was proved that the protective action of colchicine against AAA formation was mainly mediated by preventing immune cells infiltration to the aortic wall. In summary, our findings demonstrated that colchicine could protect against the development of experimental AAA, providing a potential therapeutic strategy for AAA intervention in the clinic.
The Impact of Treating Bilingual Clients on Speech-Language Pathology Students' Cultural Responsiveness
Authors: Wolford Laura L. , Wolford George W. , Smith Lúcia , Clement Alexis , de Diego-Lázaro Beatriz
Published: September 2023

Purpose:

Graduate programs often use practicum experience with clients from nonmajority cultures to improve students' cultural responsiveness. Yet, it is not clear whether simply working with a client from a nonmajority culture actually confers this benefit or whether students are thinking about how to include culturally responsive behaviors when they are considering how to address a clinical case.

Method:

Twenty first-year speech-language pathology graduate students (10 Spanish–English bilinguals, 10 monolingual English speakers) were split into three groups: monolingual experimental (
n =
4), bilingual experimental (
n =
4), and control (
n =
12). The experimental groups completed a structured practicum with bilingual Hispanic/Latino clients. They received a 1-hr training in cultural responsiveness and then implemented a systematic language intervention in English or Spanish. Changes to cultural responsiveness were measured via think-aloud cases, and changes to confidence were measured with published, self-report scales. Reflective journal entries revealed what aspects of the clinical practicum students found most salient.

Results:

Experience working with bilingual clients did not have a substantial effect on students' confidence in their cultural competence. No substantial change was found in cultural responsiveness on the think-aloud for any group. Cultural responsiveness did not appear to be top-of-mind for the students.

Conclusions:

Simply working with clients from nonmajority cultures does not create a scenario where cultural responsiveness is likely to improve. Additional targeted, purposeful training in cultural responsiveness is necessary.
Speech and Language Assessment for Urdu Speakers in the United States
Authors: Roepke Elizabeth , Alvi Hiba
Published: September 2023

Purpose:

This aim of this tutorial was to review assessment tools for speech-language pathologists working with Urdu speakers in the United States.

Method:

We outlined cultural and linguistic considerations for speech-language pathologists to consider when assessing Urdu speakers. We also reviewed available Urdu-language tests for pediatric and adult populations by their assessment area and evaluated whether they had been validated for Urdu speakers.

Results:

Speech-language pathologists should consider the impact of cultural and linguistic differences when planning assessment. In particular, many Urdu speakers are Muslim; hence, clinicians unfamiliar with the religion should open communication with clients about assessment preferences. Testing instruments covering the major areas of speech-language pathology are available for Urdu speakers in the United States.

Conclusions:

Speech-language pathologists can use the tools presented in this tutorial to evaluate both body impairments for Urdu speakers and the impact on an individual's participation. A summary of resources for Urdu speakers with links to assessments is provided in
Supplemental Material S1
.

Supplemental Material:

https://doi.org/10.23641/asha.24147564
An AI powered system to enhance self‐reflection practice in coaching
Authors: Jelodari Mahdi , Amirhosseini Mohammad Hossein , Giraldez‐Hayes Andrea
Published: September 2023

Self‐reflection practice in coaching can help with time management by promoting self‐awareness. Through this process, a coach can identify habits, tendencies and behaviours that may be causing distraction or make them less productive. This insight can be used to make changes in behaviour and establish new habits that promote effective use of time. This can also help the coach to prioritise goals and create a clear roadmap. An AI powered system has been proposed that maps the conversion onto topics and relations that could help the coach with note‐taking and progress identification throughout the session. This system enables the coach to actively self‐reflect on time management and make sure the conversation follows the target framework. This will help the coach to better understand the goal setting, breakthrough moment, and client accountability. The proposed end‐to‐end system is capable of identifying coaching segments (Goal, Option, Reality, and Way forward) across a session with 85% accuracy. Experimental evaluation has also been conducted on the coaching dataset which includes over 1k one‐to‐one English coaching sessions. In regards to the novelty, there are no datasets of such nor study of this kind to enable self‐reflection actively and evaluate in‐session performance of the coach.
Toxicity and Management of Waste Anesthetic Gases Using The Sci-Med Oxygenator
Authors: Springer Jean M. , Murray Brian P. , Romo Rosalie
Published: September 2023

Toxic anesthetic waste products need to be scavenged to protect ourselves and our future generations. Heart teams using bubble oxygenators and membrane oxygenators requiring a Y in the scavenger line, should consider the Bain Circuit which is described below.
A Simplified Blood-Cardioplegia Delivery System
Authors: Nelson David , Theis Donald , Howe Jeffrey , Bolsis Sandra , Nicoloff Demetre M.
Published: September 2023

A single-pump, one-pass, hemodilution system for administering cold blood cardioplegia during heart surgery is described. The system offers simple, quick, and effective myocardial protection.
Case Reports: Use of Intraoperative Dye Dilution Cardiac Output in the Diagnosis of Hypoxia Due to Persistent Shunting After Intracardiac Repair with Cardiopulmonary Bypass
Authors: Lefever Gerald S. , Stephenson Larry W. , Hillyer Priscilla , Showan Ann M.
Published: September 2023

The rapid diagnosis of hypoxemia following repair of intracardiac defects is crucial. Although the technique of thermodilution cardiac output is popular in operating rooms and in intensive care units, it yields little information regarding intracardiac shunting. In this report of two pediatric cases, the examination of dye dilution cardiac output curves obtained intraoperatively post intracardiac repair and cardiopulmonary bypass allowed the prompt diagnosis of persistent right-to-left shunting through unrecognized cardiac defects. The dye dilution technique should be considered intraoperatively after cardiopulmonary bypass when hypoxemia may be due to residual intracardiac shunting.
Das eigenständige Medikamentenmanagement
Authors: Pfennig Ralf
Published: September 2023

Könnten nicht auch in der psychiatrischen Klinik Patientinnen und Patienten morgens die Tabletten für den ganzen Tag ausgehändigt bekommen – so wie es in somatischen Abteilungen üblich ist? Das fragten sich Pflegende der Kliniken im Theodor-Wenzel-Werk in Berlin-Nikolassee und initiierten ein Projekt zum eigenständigen Medikamentenmanagement.
Die vergessenen „Reichsausschusskinder“ der Heil- und Pflegeanstalt Wiesloch 1940 bis 1941
Authors: Janzowski Frank , Rau Hansi
Published: September 2023

Während des Nationalsozialismus fanden zahlreiche Gewalttaten an Kindern mit schweren Behinderungen statt. Belegt ist, dass unter anderem in einer „Kinderfachabteilung“ der Wieslocher Heil- und Pflegeanstalt (heute: Psychiatrisches Zentrum Nordbaden) zwölf Kinder mit Behinderungen getötet wurden. Um ihnen zu gedenken, zeichnen wir die Chronik ihrer Pein und ihrer Peiniger nach.
Praxistrainer*in Deeskalation
Authors: Borgwedel Doris , Mengel Sven , Schmidt Simone
Published: September 2023

Gewaltereignisse gehören in psychiatrischen Kliniken für alle Berufsgruppen mit direktem Patientenkontakt mehr oder weniger zum Alltag. Gleichzeitig haben nicht alle Mitarbeitenden das erforderliche Fachwissen, um kompetent damit umzugehen. Damit das Thema Deeskalation präsenter und das Schulungsangebot umfangreicher wird, implementierte das Zentralinstitut für Seelische Gesundheit die bereichs- und berufsgruppenübergreifende Funktion „Praxistrainer*in Deeskalation“.
Leid und Unrecht von Kindern und Jugendlichen in Heimen und Psychiatrien nach 1945
Authors: Beyer Christof , Rotzoll Maike
Published: September 2023

Studien belegen, dass Kinder und Jugendliche nach dem Zweiten Weltkrieg in Einrichtungen der Behindertenhilfe und psychiatrischen Kliniken Misshandlungen und Gewalt ausgesetzt waren. Wir beleuchten die Ursachen und Hintergründe und lassen Betroffene zu Wort kommen.
Einfluss von Ober- und Untertönen auf die Melodieerkennung mit einem Cochlea-Implantat bei SSD
Authors: Schulz Kira Viviane , Gauer Johannes , Martin Rainer , Völter Christiane
Published: September 2023

Viele Träger*innen eines Cochlea-Implantats (CI) können Tonhöhen und Melodien schlecht erkennen, da die Tonhöhenübertragung unscharf und verschoben ist. Diese Studie untersucht, ob postlingual ertaubte erwachsene CI-Träger*innen Melodien besser erkennen, wenn Obertöne entfernt oder Untertöne hinzugefügt werden.

Eingeschlossen wurden 15 einseitig postlingual ertaubte CI-Träger*innen (Single Sided Deafness, SSD) im Alter von 22–73 Jahren (MW 52, SD 11,6) mit einer CI-Hörerfahrung zwischen 3 und 75 Monaten (MW 33, SD 21,0) mit verschiedenen MED-EL-Modellen. Drei kurze Klaviermelodien wurden ihnen zunächst auf dem normalhörenden Ohr und dann in veränderten Ober- oder Untertonvarianten und der Originalvariante auf dem CI-Ohr präsentiert. Die Varianten sollten als eine der 3 Originalmelodien identifiziert werden. Zusätzlich wurden die musikalischen Fähigkeiten und Erfahrungen durch den Münchner Musikfragebogen und den MiniPROMS-Musiktest erfasst.

Die Melodieerkennung gelang den CI-Träger*innen am besten in der Grundfrequenzvariante. Die Obertonvariante mit dem dritten Oberton ergab eine gleichwertige Melodieerkennung wie die Originalvariante aus allen Obertönen (p=1). Indes wurde die Untertonvariante mit dem ersten Unterton signifikant schlechter als die Grundfrequenzvariante erkannt (p=0,032). Ferner zeigte sich keine Korrelation zwischen der Musikerfahrung oder den musikalischen Fähigkeiten und der Anzahl an erkannten Melodien (p>0,1).

Da die Obertonreduktion die Melodieerkennung nicht verschlechtert und in anderen Arbeiten den Musikgenuss sogar verbesserte, sollte die Obertonreduktion in künftigen Musikverarbeitungsprogrammen für das CI berücksichtigt werden. Dies könnte zusätzlich den Energieverbrauch des CI reduzieren.