bluuebunny/crossref_metadata_2025 huggingface dataset:
Opportunities for Psychological Support and Accompaniment of YOUNG People with Intellectual Disabilities in Employment
Authors: Bystrova Y.A.
Published: January 2023

Purpose. The research reveals the possibilities of psychological support and advisory support for young people with intellectual disabilities (ID) in the process of their employment and work activities in order to achieve positive dynamics in matters of their professional self–determination, painless integration into the professional community and development in the profession. Procedure and methods.The study involved young people with ID aged 18 to 32 years (N=123). The experimental technology of included employment, developed on the basis of a professional labor experiment, a case method, methods of resource and positive psychotherapy, SPT, involves differentiation of the levels of readiness for employment of persons with ID (minimum, medium, sufficient) and selection for each level of the route accompaniments, which includes the provision of psychological counseling and support: employment, protected employment and escorted employment in the open market. Results and conclusions. The introduction of the technology showed that the leverage that activates the personal resources of the readiness of young people with ID to perform work tasks is specially organized working conditions and psychological support in the experimental social enterprise "Special Assembly" in combination with group trainings and individual counseling. The results of the provision of counseling psychological assistance and psychological support was a significant increase in the number of people with a sufficient level of readiness for independent work (from 27.64% to 40.65%), the indicator of responsible attitude of employees with ID towards team members increased from 1.58% to 36.50% of respondents, anxiety about failures in work activity decreased from 2% to 33.50% of respondents, 47.61% of people with ID established communication with friends at a sufficient level. 51 people are employed in the open labor market.
State Interest in the Aspect of Modern International Relations
Authors: Motova Ekaterina A.
Published: January 2023

The category interest has a long history in political, legal and philosophical thought, which cannot be said about the state interest. For the first time, according to the author, the idea of a strong state and state interest appeared in the Renaissance, which was later addressed by many thinkers of the Enlightenment. Central to the concept of a strong state and state interests is the status of the state itself, both nationally and internationally. Consequently, this topic continues to be relevant today, which is associated with the versatility and debatable interpretations of state interest in modern legal literature.
The article analyzes the categories of state interest and interest in particular, while taking as a basis the political and legal teachings of N. Machiavelli and A. Richelieu; modern interpretations of the concept of state interest in the aspect of modern international relations are investigated. The objectives of the article include an appeal to the origins of the concept of state interest, as well as an attempt to give the authors definition of this concept.
The article uses methods of interpretation, description, theoretical methods of formal and dialectical logic, comparative legal method. Private-scientific methods were used, such as: historical, retrospective, legal-dogmatic methods.
CONCLUSION: The study revealed the debatability of approaches to understanding the category of interest and the insufficient development of the concept of state interest in the theory of law. Despite the fact that in the scientific legal and political literature the concepts of state and national interests are identified, we believe that these terms are not identical to each other, therefore, they must be distinguished from each other. Thus, the state interest in the article is understood as public interest, which is officially recognized by the state and is provided by the right of interest of the state-people, broadcast by the diplomatic representatives of the state in the international arena. In our opinion, the state-people system allows focusing on the individual and his rights, highlighting the principles of respect for the honor and dignity of the individual enshrined in the Constitution of the Russian Federation, thereby obliging the state to protect them and take its legitimate aspirations under protection. And under the national interests - the internal interests of the peoples living on the territory of Russia (this is important, since the Russian Federation is a multinational state), having their own state (since the people are a sovereign that is able to freely make decisions) and striving to develop a strong, stable and a stable state capable of ensuring the security of the entire society.
The Social Significance of the Russian Prosecutor's Office: Yesterday, Today, Tomorrow
Authors: Kolesov Mikhail V.
Published: January 2023

This article examines the historical aspects of the development of the supervisory agency, and analyzes the role of the prosecutors office in the life of modern Russian society and the state, concerning the 300th anniversary of the founding of the prosecutors office in Russia. The author substantiates the importance of the existence of the prosecutor's office in the state system of authorities and its social relevance. It is particularly emphasized that at this stage of development, the main principles of the activities of the prosecutors office should be the social orientation of the prosecutors supervision and the readiness to meet the most unexpected challenges of the time, constantly guarding the interests of the state, society, and individuals.
Socio-Philosophical Views of L.N. Tolstoy on the Institutions of Law and the State
Authors: Kerimov Alexander D.
Published: January 2023

The author analyzes and undoubtedly appreciates the views of Leo Tolstoy concerning the essence, content, organization, and functioning of such relevant socio-cultural and political institutions as law and the state. He shows a positive attitude toward the corresponding views of a notable Russian thinker.

This article describes the specific, inalienable (in other words, obligatory in its kind and at the same time amazing) qualities and immanent properties of those writers and scientists who have succeeded in achieving excellent results in the spiritual comprehension of the world.

The fundamental conclusion is substantiated by the understanding of Leo Tolstoy of these institutions (at least in the part where it is a question of their criticism), which almost coincides with the Marxist doctrine.
Tax and Legal Anthropology and Modernity
Authors: Karaseva Marina V.
Published: January 2023

This article analyzes the anthropological characteristics of an individual in the context of tax and legal regulation. It is emphasized that the specifics of the sphere of tax and legal regulation allow us to consider an individual as a taxpayer with the following characteristics: he/she has a margin of discretion limited to the limit; is in an antagonistic-contradictory relationship with the state; is poorly aware of the logic of legal conduct according to the law; bears structurally the maximum permissible property encumbrance; often acquires public condemnation as a tax non-patriot. The possibilities of equalizing the emotional and psychological states of an individual within the boundaries of tax law are considered.
Functions of Legal Symbols
Authors: Goncharova Natalya S.
Published: January 2023

In connection with the role performed, the problem of legal symbols is becoming increasingly popular in the legal literature. The meaning of legal symbols is often investigated by characterizing their functions. The author has researched and analyzed the functions of legal symbols highlighted in the legal doctrine. The authors system of functions of legal symbols is proposed: regulatory, legal, informational, economy of linguistic means, identification, ideological. It is concluded that the functions of legal symbols are different in their essential content. The problem of their functioning is complex. Each legal symbol has only its inherent purpose. However, it is only by studying all the functions of symbolism that it is possible to identify the role that symbols play in modern times in the legal system.
Contemporary Problems of Implementation of the Protocol on Northern Ireland after Brexit
Authors: Galushko Dmitriy V.
Published: January 2023

The article analyses some aspects of the practice of implementing the Protocol on Northern Ireland as one of the main elements of the legal formalisation of the UK's withdrawal from the European Union. The problem of Northern Ireland was one of the central issues in the Brexit negotiation process. The found and agreed solution in the form of the Protocol on Northern Ireland initially raised many questions and concerns primarily from the UKs side, which were later confirmed during the implementation of the document. Immediately after Brexit, the British government took an official position on the need to revise the Protocol as an integral part of the withdrawal agreement, in particular, by initiating a Northern Ireland Protocol Bill, which unilaterally terminates a number of provisions of the Protocol. It is quite natural that such actions on the British side caused indignation of the European Commission, which initiated the appropriate judicial procedure against the UK. An analysis of the process of implementation of the Protocol on Northern Ireland allowed the author to conclude on the negative consequences of the decisions taken by the British government for bilateral relations with the European Union in various fields, as well as the implementation of other provisions of the concluded agreement on trade and cooperation between the two sides. The scientific methods for the underlying research in this article are well-known. The purpose and objectives of the work are to study the relevant problems associated with the implementation of the Protocol on Northern Ireland, the factors contributing to them, as well as the consequences of the decisions taken.
Maximum Tolerable Intake of Mangrove Oyster (Crassostrea rhizophorae) from the Tapak River, Semarang City, Indonesia, which Contains Cd and Pb Metals
Authors: Haeruddin Haeruddin , Ayuningrum Diah , Oktaviani Jessika
Published: January 2023

Mangrove oysters are a type of oyster typical for human consumption in Semarang City. The Tapak River in Semarang is a popular fishing ground for mangrove oysters, but it is also contaminated with cadmium (Cd) and lead (Pb) metals. This research was determined to analyze the concentration of Cd and Pb metals in mangrove oyster meat from the Tapak River and determine the maximum tolerable intake for humans. Oysters were collected from 3 stations with 3 replicates per station. Metal concentrations in mangrove oyster meat were analyzed with a wet digestion method followed by atomic absorption spectrophotometry. Most of the meat samples contained Cd exceeding standard concentrations for shellfish and all meat samples contained Pb exceeding the standard concentrations for shellfish. The maximum tolerable intake of Cd and Pb for human adults is 0.954 ± 0.431 mg week-1 and 0.164 ± 0.014 mg week-1 respectively.
Komposisi Kimia dan Aktivitas Kerang Balelo (Conomurex sp.) dalam Menghambat Enzim α-Glukosidase
Authors: Nurhikma Nurhikma , Riviani Riviani , Wulandari Diah Anggraini , Mirsa Mirsa
Published: January 2023

Kerang balelo merupakan salah satu kelas gastropoda yang dimanfaatkan masyarakat pulau Derawan sebagai laut pengganti ikan dan obat tradisional dalam penyembuhan penyakit. Pada beberapa penelitian jenis gastropoda potensial sebagai keperluan nutraceutical maupun pharmaceutical. Tujuan penelitian ini yakni mempelajari karakteristik kimia dan menentukan aktivitas antidiabetes dari kerang balelo segar. Metode penelitian terdiri dari tiga tahapan yakni tahap pertama karakterisasi kimia meliputi uji asam amino, asam lemak, mineral dan logam (kalsium, tembaga, besi, selenium, seng, merkuri), tahap kedua ekstraksi menggunakan tiga jenis pelarut (metanol, etil asetat, n-heksana), tahap ketiga penentuan aktivitas antidiabetes kerang balelo segar. Kandungan asam amino esensial tertinggi kerang balelo terdapat pada leusin yakni 2,70%, dan asam amino non esensial tertinggi yakni asam glutamat sebesar 4,22%, kandungan asam lemak kerang balelo segar yakni 19,20%, kandungan mineral tertinggi yakni iron (Fe) sebesar 90,60 mg/kg. Hasil analisis aktivitas inhibisi α-glukosidase kerang balelo menunjukkan bahwa ekstrak metanol, n-heksana dan etil asetat tidak berpotensi sebagai antidiabetes.
Nutritional Characteristics of Curry fish Sea Cucumber (Stichopus vastus) using Chemicals and Physical Treatment
Authors: Sukmiwati Mery , Sumarto Sumarto , Sidauruk Santhy Wisuda , Ibrahim Irvan
Published: January 2023

Indonesia is one of the main sources of sea cucumber in the world with high total production for domestic consumption and export market. Sea cucumber has potential as a source of traditional foods, medicine, and functional food due to the high nutritional component in sea cucumbers. The purpose of this research was to determine the different nutritional characteristics of   sea cucumber obtained by chemical (ethanol extractions of 20%, 25%, and 30%) and physical treatment (boiling and steaming). The results showed that chemical treatment (30% ethanol) had the best nutritional components being composed of protein 77.35%; moisture 9.14%; ash 6.67%; fat 0.10%; and carbohydrate 6.18%, while in physical treatment, steaming had the best nutritional components in composed of 61.49% protein content, 11.53% moisture, 10.76% ash, 2.22% fat, and 14.00% carbohydrate. Amino acid profiles in chemical treatments (ethanol 20%, 25%, and 30%) were 53.60%, 56.74%, and 61.65% respectively, while the amino acid profiles in physical treatments (boiling and steaming) were 50.31% and 52.96%, respectively. Glycine and glutamate acid, non-essential amino acid, were dominated by both chemical and physical treatments.
Relationship between the Corporate Disclosure and Profitability: An Empirical Analysis of the Commercial Banks in Bangladesh
Authors: Das Ranjit Kumar
Published: January 2023

Disclosure is essential for interested users to make logical decisions. This study evaluates the extent of corporate disclosure and its relationship with the profitability attributives of banking companies in Bangladesh. To achieve the study purpose, this study has taken five private commercial banks in Bangladesh for five years from 2016 to 2020. The required data have been collected mainly from secondary sources. To reach the study findings per study objectives, the researcher has employed different statistical techniques, analyzed the various annual reports to calculate the level of corporate disclosure, and identified the different profitability attributives. The results of descriptive statistics show that the highest mean value is visible in the case of SB_3, and the lowest mean value is visual in the case of SB_4, but SB_4 and SB_5 show the lowest and highest standard deviation values. The ANOVA test results show significant variation in the level of corporate disclosure and different profitability attributes among the sample banks over the study period. The simple regression results show a substantial relationship between the corporate disclosure scores and profitability attributives. The effects of multiple regression present that other profitability attributes like profit before tax and earnings per share significantly impacted corporate disclosure scores. However, the remaining attributes, like operating profit, profit after tax, return on equity, and return on asset, had an insignificant positive impact on the corporate disclosure scores of the sample banks over the study period. This research study has recommended that the management of the banking companies should take necessary steps to ensure an adequate level of corporate disclosure in reporting practices because the different stakeholders make any decision based on disclosing information.
The Perinatal Workforce Pipeline and Strategies for Meeting Community Need
Authors: Coulson Carol C. , Galvin Shelley L.
Published: January 2023

Significant deficits in the national perinatal workforce are expected over the next three decades, and North Carolina is no exception. Rural communities are especially at risk of not meeting community need. Numerous strategies in Western North Carolina are being leveraged to maintain a robust, well-trained, and diverse perinatal work force.
“I Gave Birth”—An Initiative to Improve Postpartum Care
Authors: Noble Jessica , Harper Kimberly D. , Mitchell Kathryn , McClain Erin K.
Published: January 2023

New families need support, information, and resources to navigate their postpartum recovery. The “I Gave Birth” initiative educates communities to improve outcomes in Perinatal Region VI and across North Carolina. Evaluation of the initiative demonstrated that health care system and community-wide awareness of maternal warning signs leads to early recognition and treatment of maternal complications.
Training Up Future Generations of Antiracist Professionals: The Health Equity and Racism Lab
Authors: Baker Stephanie , Faustin Yanica
Published: January 2023

The Health Equity and Racism Lab centers an analysis of racism, deepening understanding of the historical and contextual ways that “race” has structured society and therefore our outcomes, and of antiracist solutions—race-based (not race-neutral) solutions that focus on systems and structure change to address inequities.
Maternal Outreach Through Telehealth for Rural Sites: The MOTHeRS Project
Authors: Atezaz Saeed Sy , Jones Katherine , Sacks Alan J. , Craven Kay , Xue Yajiong (Lucky)
Published: January 2023

The coronavirus pandemic brought challenges to rural maternal health. A patient-centered collaborative health care model using telehealth and health technologies was developed by professionals at ECU and implemented in Carteret, Duplin, Chowan, and Dare counties. Preliminary results show improvement in care access and reduced health disparities.
Regional Trends of COVID-19-Like Illness- Related Emergency Department Visits in North Carolina (March 1, 2020–November 30, 2020)
Authors: Kearney Gregory D. , Hylock Ray , Park Yoo Min , Jones Katherine , Wall Bennett , Howard Rob , Iyer Pooja , Clay Maria , Endres-Dighe Stacy , Stoner Marie C.D. , Li Lei , Cajka James , Rhea Sarah
Published: January 2023

Background

An evaluation of emergency department (ED) visits and the number of patients seeking care for COVID-19-like illness (CLI) during the initial phases of the SARS-CoV-2 (COVID-19) pandemic in North Carolina has not been exclusively described.

Purpose

To characterize CLI-related ED visits across North Carolina from March 1 to November 30, 2020.

Methods

This was a retrospective, descriptive study. Data from the North Carolina Disease Event Tracking and Epidemiologic Collection Tool (NC DETECT) and the US Census Bureau were used to calculate CLI-related ED visit rates for the North Carolina resident patient population, and to compare and describe regional trends (Eastern, Piedmont, and Western).

Results

A total of 133,193 CLI-related ED visits were evaluated. Across the 3 regions, CLI-related ED visits followed similar trends with the highest peaks being reported in mid-July and late November 2020. The Piedmont region experienced the highest percent (56.3%), while people aged 25–49 years accounted for the largest age group (35.0 %) of CLI-related ED visits. More CLI-related ED visits occurred for White individuals (47.8%), but the Eastern region had a far higher percent (44.8%) of reported CLI-related ED visits for Black and American Indian individuals compared to the rest of the state.

Limitations

ICD-10-CM codes were not available during the early weeks of the pandemic, which limited the ability to evaluate CLI-related data during this time.

Discussion

This evaluation summarizes regional trends of CLI-related ED visits across North Carolina during the first 9 months of the COVID-19 pandemic. These results provide useful information and insight for public health officials, health care administrators, and policymakers.
Evaluating a Health Care Pathway Internship Program for Minority High School Students
Authors: Hallum Jacquelyn , Denslow Sheri , Kovalskiy Aleksandr , Poulton Ginger , Bemis Rachel , Wallace Elisabeth , Fromewick Jill
Published: January 2023

Background

In 2005, Mountain Area Health Education Center (MAHEC) collaborated with community partners to establish the Minority Medical Mentoring Program (MMMP), a semester-long health care pathway internship for high school seniors of color. This evaluation aimed to assess program participants’ perceptions of program components, identify areas for improvement, and broaden the evidence base of pathway programs.

Methods

Seventy-three MMMP alumni were invited to participate in an online survey. Closed- and open-ended questions aimed to assess respondents’ perceptions of program components and MMMP’s impact on their personal and professional lives.

Results

Forty-six alumni responded to the survey. The MMMP was perceived as universally valuable. Clinical shadowing, mentors of color, and exposure to a variety of health professionals were viewed as the most valuable program components. The MMMP strengthened participants’ awareness of health disciplines, improved their self-confidence, and increased their professional skill sets. Surprisingly, the MMMP enabled some participants to recognize health career interests outside of clinical care.

Limitations

Selection, social desirability, and recall bias may limit interpretation of findings.

Conclusion

The MMMP is highly valued by participants. A high majority of respondents (40/46; 87%) plan to have a health career in the future. Pathway programs can shape career paths, increase self-awareness, and build self-confidence for success. It is important to note that systemic racism and discrimination must be addressed to fully ensure recruitment and retention of health care providers of color.
Challenges and Opportunities for Graduate Medical Education: Steps to Keep Physician Training in North Carolina Exceptional
Authors: Garrison, MD, MPH Herbert G.
Published: January 2023

Changes in health care present many challenges and opportunities to North Carolina's exceptional graduate medical education programs.
Control of noise and temperature using radial air injection inside engine silencer
Authors: DESHMUKH Nilaj , WAGHMODE Abhijit
Published: January 2023

Silencer is a device mainly used for attenuation of the engine exhaust noise. Several modifications were attempted to improve the performance of a silencer. In this paper experimental and simulation study was carried out to determine the effect of radial air injection on the temperature and sound pressure level. The radial air injection is introduced in the form of jets inside the silencer. The design of available silencer was studied, and the 3D model was prepared using CATIA software. Simulation study was carried out using ANSYS Fluent, to determine the temperature distribution inside the silencer with and without modification. The radial jets at different pressure were introduced inside the silencer at three different locations. To acquire sound pressure level and temperatures at different locations, Lab View software and FFT analyser were used. The performance of silencer is analysed by comparing temperature of exhaust gases and sound pressure level at constant speed of 3000 rpm. With radial air jets of 2 bar reservoir pressure at three different location Overall Sound Pressure Level reduces by 6 dB and 42 K reduction in temperature of exhaust gases.
CFD modeling of influenza virus diffusion during coughing and breathing in a ventilated room
Authors: ALJABAIR Sattar , ALESBE Israa , ALKHALAF Ali
Published: January 2023

The virus diffusion in a ventilated room with the droplets produced by coughing and breathing are presented by the Lagrangian model. When the human body is located in the middle of the room with two locations of AC, in front of and behind the human body, three angles of Air Conditioning (AC) gate are applied 0°, 30°, and 60° to show droplet particle diffusion in the room in these cases. Three types of coughing velocity profiles were selected, real human coughing, sinusoidal cough, and cough jet with one velocity profile of breathing as a step function to cover the inhaling and exhaling cycle. The simulation results show that the uncovered standing in the middle of the room, are more susceptible to infection for the bouncy and forced flow around the human body. Droplet particle moves in the room as a random diffusion and it is very sensitive to the thermal load inside the room, generally depends on the bouncy force and pressure force due to convection heat transfer. when the AC location at the opposite direction of coughing flow, the droplet travels a distance of about 3 m, 2.85 m, and 2.75 m for real cough, sinusoidal cough, and cough jet respectively. While the droplet travel distance is about 3.1 m, 3.2 m, and 2.9 m when the AC location is at the same direction of coughing flow. Finally, the adopted CFD modeling was also used to show the effects of different AC locations on coughing, breathing particle droplets distribution in different indoor spaces, such as buildings, hospitals, and public transports, Also, showed good visual demonstration and representation of the real physical processes.
Energy, exergy analysis and optimization of insulation thickness on buildings in a low-temperature district heating system
Authors: TERHAN Meryem , ABAK Sena Saliha
Published: January 2023

In the study, energy and exergy analysis of the buildings on a campus in Turkey are conducted by using actual operating data and taking measurements in the district heating system as a case study. The energy and exergy demands, losses that stem from all buildings are calculated according to average daily outdoor temperature data. Due to the high heat losses in the buildings, determining the optimal insulation thickness for the exterior wall should be investigated. Therefore, optimal insulation thicknesses, energy savings, fuel consumptions and payback periods of the insulation material on the exterior wall of the building are examined by using Life Cycle Assessment and P1–P2 method for natural gas. Optimal insulation thicknesses are calculated for different insulation materials such as XPS, glass wool, rock wool and EPS for the climatic regions (HDD=800–4250°C days). According to average exergy losses from the building components per unit area, the average total exergy loss is calculated as 2.39×10-2 kW/m2.year and 1.42×10-3 kW/m2 (5.92%) of this loss stems from the exterior walls, 1.93×10-3 kW/m2 (8.07%) from the floors, 7.37×10-4 kW/m2 (3.08%) from the roofs, 1.58×10-2 kW/m2 (65.99%) from the windows and doors, 4.04×10-3 kW/m2 (16.92%) from the ventilation with infiltration. Energy requirement values of the building are found between 2.68–25.70 kWh/m3 towards from the warmest to the coldest climatic region for the uninsulated wall. In the un-insulated state, fuel consumption varies between 1.93-18.48 m3/m2 from the warmest to the coldest region. The optimal insulation thickness values of the building’s exterior wall are calculated as between 2.3–10.0 cm according to different climatic regions. In-state of exterior wall insulation of 3 cm, fuel consumption decreases by 46.63%–53.46% compared to different insulation materials and climatic regions compared to the un-insulated state.
Ethosome as a potential transdermal drug delivery system
Authors: Khanam Sofia , Sheel Sumon , Biswas Poulomi , Karmakar Varnita
Published: January 2023

Ethosomes are elastic nanovesicles with phospholipid bases that are noninvasive delivery vehicles and have a high ethanol concentration (20–45%). As transdermal drug delivery confers poor penetration, the major obstacle is the low diffusion rate of drugs across the stratum corneum. The sophisticated ethosomal delivery systems enable drugs to reach the deep skin layers and/or the systemic circulation. The development of these new carriers involves the employment of several preparatory processes. Ethosomal dispersions are added to gels, patches, and creams for ease of use and stability. Ethanol is known as an efficient permeation enhancer and has been added in the vesicular systems to prepare elastic nanovesicles. It has the potential to interact with the polar head group region of lipid molecules, lowering the melting point of the stratum corneum lipid and raising lipid fluidity and cell membrane permeability as a result. Ethosomes' special structure allows them to enclose and transmit through the skin highly lipophilic substances like propranolol and trihexyphenidil as well as cationic medicines like testosterone and minoxidil. This article provides a detailed review of the ethosomal structure, mechanism of penetration along with various methods of preparation. Also, the article focuses on the applications of ethosomal carriers and opportunities for the research and future development of novel improved therapies.
Effect of Withania Somnifera (L.) root extract\'s on PC12 induced by hydrogen peroxide, study
Authors: Kumar Ravi , Dhariwal Rajat , Kumar Anurag , Minata Miss
Published: January 2023

The L. is also used as a crude medicament that mostly effected in various neurological and immunological disorders. It is also known as Ashwagandha and “Indian ginseng” in Indian region. There is a lack of information on the possible neuroprotective properties of W. somnifera root against HO- and Ab(1-42)-induced cytotoxicity, which are now targeted for innovative treatments for dementia, particularly dementia of the Alzheimer's type (AD). According to this research, we prepared an aqueous extract of dried roots of W. somnifera that possess the protective effect against Ab- aggregated fibril and HO cytotoxicity through MTT assay with the help of differentiated rat pheochromocytoma PC12 cell. The findings indicate that, in a concentration-dependent manner, pretreatment of differentiated PC12 cells with aqueous extracts of W. somnifera root strongly protects differentiated PC12 cells against both H2O2- and Ab(1-42)-induced cytotoxicity. The W. somnifera extract was examined using liquid chromatography-serial mass spectrometry in order to look into the substances that could be responsible for the effects that were seen. Withanolide derivatives, notably withaferin A, were found in abundance. These findings support the hypothesis that W. somnifera may be used ethnopharmacologically to treat oxidative stress-related cognitive and other neurodegenerative illnesses. They also show the neuroprotective activities of an aqueous extract of W. somnifera root.
Development of UV-Visible spectrophotometric method for the estimation of vildagliptin in different medium
Authors: Mane Sheetal Sheetal , Khan Masheer Ahmed
Published: January 2023

A simple, accurate, precise, cost effective, rapid and sensitive UV/visible spectrophotometric method was developed for the determination of Vildagliptin in active pharmaceutical dosage form. The developed method was validated as per ICH guidelines.

The purity of Vildagliptin was characterized by melting point, Fourier Transform Infra-Red and DSC. The drug was analyzed using UV/visible spectrophotometric method was validated in terms of linearity and range. The solvents used was water, 0.1 N HCl and phosphate buffer pH 7.4 and the wavelength corresponding to maximum absorbance of the drug were found at 210 nm.

Melting point of drug was found 151.67°C nearly corresponds to its actual melting range. The linear response for concentration range of 2-12 µg/ml of vildagliptin for water, 0.1 N HCl and phosphate buffer pH 7.4 was recorded each with regression coefficient R = 0.9998, 0.9994 and 0.9991 respectively.

The drug was confirmed by interpretation of UV spectra. Hence, proposed method stands out validated and shows a linear relationship and thus may be used for routine analysis of Vildagliptin in pharmaceutical dosage forms.
Case report: A case of Pseudoepitheliomatous hyperplasia of vulva, a differential diagnosis for squamous cell carcinoma of external genitalia in women
Authors: Harshini V , Alva Kishore
Published: January 2023

A woman presenting with vulval lesions is to be examined and evaluated further before giving her the definitive diagnosis and proposing treatment. As the differential diagnosis may vary from benign lesions like lichen sclerosus, vulval intraepithelial neoplasia or malignant lesions like squamous cell carcinoma. We are presenting a case report wherein 70 year woman presented with features similar to squamous cell carcinoma but was diagnosed as pseudoepitheliomatous hyperplasia of vulva which is a benign lesion.

Pseudoepitheliomatous hyperplasia (PEH) is a benign condition, characterized by hyperplasia of the epidermis and adnexal epithelium, closely similar to squamous cell carcinoma. PEH may be present in a number of conditions characterized by prolonged inﬂammation and/or chronic infection, as well as in association with many cutaneous neoplasms.
“The Ice is Melting and I Don’t Want Santa to Drown!”: Reflections on Childhood, Climate Action, and Futurity
Authors: Hopkins Lucy
Published: January 2023

This paper’s reading of a specific cultural artifact to emerge from children’s climate activism in contemporary Australia enacts an argument that children themselves can be seen to be redefining childhood and futurity through their climate activism and demonstrates how their placards are evidence of this. It argues that we as critical childhood scholars can follow their lead by uncovering the discourses that underpin their activist slogans. In doing so, we can set about contesting the limiting and disempowering discourses of childhood that would dismiss the very idea of children as political participants in the fight to save the planet.
Analysis of Permanent Preservation Areas Surrounding Springs Through Satellite Images
Authors: Gonçalves Ribeiro José Rafael , Lacerda Camila , Borges Paulo , Simões Débora Paula
Published: January 2023

The use of remote sensing and digital processing of images is increasingly present in the monitoring and analysis of environmental data, mainly due to the ease of obtaining orbital images and the advanced methods of image classification. Temporal evaluation of restoration of native vegetation surrounding springs is important for the protection of water resources. A project named Water Conserver (Conservador das Águas) was developed between 2005 and 2015, involving 380 springs in Extrema, state of Minas Gerais, Brazil, focused on the preservation of water sources. The present study was carried out to quantify and analyze Permanent Preservation Areas (PPA) surrounding these water bodies. Free orbital images with spatial resolution of 30 m were acquired from the satellites Landsat-7 and Landsat-8 in 2003 and 2021, respectively. Object-oriented classification was used to evaluate the total PPA of restored springs over 18 years. The success of the Water Conserver Project resulted in a total restoration of more than 82% of areas surrounding springs up to 2021.
Diversity and conservation of birds associated with an urban landscape in the southwest Brazilian Amazon
Authors: Moura Aloysio Souza de , Candido Edilson , Machado Felipe Santana , Leite Leandro Henrique , Mariano Ravi Fernandes , Fontes Marco Aurélio Leite
Published: January 2023

The Amazon presents an arc of deforestation which has expanded into natural areas and bird community studies in these areas are incipient for urban landscapes after transformation. Therefore, the bird community in an urban landscape in the southwest Amazonian region within an area in the arc of deforestation was investigated. The observations were performed through linear transects, during the wet and dry seasons of 2013. Records were obtained using binoculars and cameras. A total of 191 species of birds were recorded. The species accumulation curve was not reaching the asymptote, showing that new species can be recorded with a sampling effort increase. The community has low richness as a result of pressure on Amazonian environments and a high degree of anthropization. However, there is relevant composition, because nectarivores, insectivorous, carnivores, omnivores, and granivores were found in all environments, as well as endemic and threatened species.
Mapping of restrictive factors of land in the hydrographic basin of the middle section of the Paraíba River
Authors: Francisco Paulo Roberto Megna , Silva Viviane Farias , Santos Djail , Ribeiro George do Nascimento , Ayres Gypson Dutra Junqueira
Published: January 2023

This work aimed to identify and map the pedological restrictions of the lands in the middle course of the Paraíba River. For this, GIS SPRING, digital soil map, and the Agricultural Zoning of the State of Paraíba information were used. From these, pedological data were extracted to classify the soils based on salinity/sodicity, effective depth, stoniness, fertility, erosion, drainage, and texture. Data were interpreted and classified according to soil-restricting factors (null, light, moderate, strong, very strong, and extremely strong). It was observed that the most common land use restriction factors in the strong class were texture, effective depth, and stoniness; in the moderate class, erodibility, slope, and fertility; in the light class, slope; and in the null class, salinity and drainage.
Fixed-time artificial insemination in Churra Galega Bragançana ewes:
Authors: Silva Daiane Moreira , Miranda Pires Quintas Hélder , Sampaio dos Santos Liliana Maria , De Carvalho Neves Álvaro Armindo , Pereira Afonso Paulo Jorge , CorujeiraValentim Ramiro
Published: January 2023

This work was carried out with the objective of studying the effect of the anti-reflux device for ovine insemination (DARIO) on the fertility rate in ewes of the native Portuguese breed Churra Galega Bragançana (CGB) artificially inseminated at fixed-time. Eighty-one ewes aged between one and five years were used. At the end of April 2021, ewes’ reproductive control was carried out, using a short progestagen treatment (five days) + equine chorionic gonadotropin (eCG). Cervical artificial insemination (AI) was performed at fixed-time (55 hours after the end of the hormonal treatment), with cooled semen. All ewes were inseminated by the same inseminator: 39 ewes with the DARIO tip on the end of the sheath and 42 without this tip. The pregnancy diagnosis was made by ultrasonography 41 days after AI. Age and body condition (BC) did not affect the ewes’ response to the applied hormonal treatment or the fertility rate. Approximately 95.1% of the ewes responded to the progestagen + eCG treatment. Forty-one days after AI, 86.4% of the ewes were pregnant. The use of the DARIO tip did not affect the fertility rate.
Reliable, Possible, and Improbable About Student Years of Hryhorii Skovoroda
Authors: Yaremenko Maksym
Published: January 2023

To this day the biography of young man Hryhorii Skovoroda is mostly a set of assumptions and conjectures than history about his life based on more or less authentic facts. Even the year of the philosopher’s birth is not as obvious as it is commonly supposed. Excessive trust in the specific work of Mykhailo Kovalynskyi about Skovoroda attempts to adjust those up to thinker’s time sources to much later information of Kovalynskyi’s work harm the critical study of Hryhoriy Savych’s biography. In this article on the basis of both well-known and new facts the established historiographical statements about the time of Skovoroda’s birth and education are revised or questioned. He could not start his studies at the Kyiv-Mohyla Academy before 1738/39 and completed them, most likely, no later than January 1750. It seems the gap in Hryhorii’s studying because of his singing in the court chapel lasted longer than scholars assumed before.
Between Biography and Propaganda: Mykhailo Kozachynsky’s «Journal or Description of the Years and the Glorious as well as Solemn Victories of the Blessed and Everlasting Memory Peter the Great, Pater Patriae, the First All-Russian Emperor» (1744)
Authors: Potapenko Svitlana
Published: January 2023

The article focuses on a little-known literary work about Peter I which was composed by a Ukrainian poet, philosopher, and professor of the Kyivan Academy, Mykhailo Kozachynsky (1699–1755). This poetic biography was entitled «Journal or Description of the Years and the Glorious as well as Solemn Victories of the Blessed and Everlasting Memory Peter the Great, Pater Patriae, the First All-Russian Emperor». It was appended to a trilingual panegyric «Augustissimae ac Invictissimae Imperatrici» of the same authorship written in honor of the Empress Elizabeth’s of Russia visit to Kyiv in August-September 1744. The panegyric, the «Journal», a shortened edition of a dramatic play along with a poem and a canto formed a complex of works, which were published in the Kyiv-Pechersk printing house. One more of Kozachynsky’s related poem appeared in Wroclaw on the same occasion.The textual analysis of the «Journal» demonstrates that the author dealt with Feofan Prokopovych’s eulogies that glorified Peter I and were released in Kyiv and Saint-Petersburg throughout 1709–1725, namely «Panegyricvs de celeberrima et paene inavdita victoria qvam Pertvs Primva», «The Word to praise the Poltava Battle», «The Word on the Burial of the Most Illustrious Sovereign Peter the Great» and «The Word to Praise the Blessed and Everlasting Memory Peter the Great». In addition, Kozachynsky borrowed facts about the Great Northern War mostly from the so-called «The Mars’s Book» and then poetically reworked them. Such a richly illustrated collection of reports on the course of military affairs was published for the first time shortly after 1713 and later underwent several reprints.Taken in general, the context in which the «Journal» and the corresponding series of Mykhailo Kozachynsky’s works appeared reveals clearly that the Ukrainian elite of that time pursued the only goal to utilize Elizabeth’s arrival to Ukraine as an opportunity to lobby for the urgent issue of the restoration of the hetmanship. The splendor of the meeting with the special glorification of the Empress’s father served therefore as a propaganda tool to achieve this goal.
Adaptação cultural do instrumento The Process and Quality of Informed Consent para o português brasileiro
Authors: Camasmie Paula Miranda , Gaydeczka Beatriz
Published: January 2023

Objetivo: apresentar resultados da adaptação cultural do The Process and Quality of Informed Consent para o português brasileiro. Método: pesquisa descritiva, quali-quantitativa e transversal, desenvolvida em 2019, cujos procedimentos foram de traduções, análises consensuais e avaliação de equivalência por um comitê de juízes, retrotradução e avaliação semântica. Resultados: participaram 6 juízes, com título de doutor, domínio sobre a temática e conhecimento do idioma inglês e 12 pacientes de estudos clínicos, maiores de 18 anos. Obteve-se o instrumento O Processo e a Qualidade do Consentimento Informado adaptado transculturalmente, que originalmente tinha e, após adaptação para o português, manteve 20 itens. Conclusão: o instrumento adaptado demonstrou poder avaliar o processo de consentimento informado em Pesquisas Clínicas e as intervenções destinadas a melhorá-lo.
Cuidados de enfermagem em saúde reprodutiva à mulher na Atenção Primária à Saúde: revisão integrativa
Authors: Paixao Tatiane Taiz , Wall Marilene Loewen , Aldrighi Juliane Dias , Benedet Deisi Cristine Forlin , Trigueiro Tatiane Herreira
Published: January 2023

Objetivo: conhecer o estado da arte sobre a saúde reprodutiva das mulheres no que diz respeito aos cuidados de enfermagem na Atenção Primária à Saúde. Método: revisão integrativa, considerando o período entre 2016 e 2021, realizada em setembro de 2021, nas bases de dados Biblioteca Virtual de Saúde, PubMed/Medline, CINAHL, Web of Science e Scopus. Resultados: foram selecionados oito artigos que evidenciaram três categorias: Cuidado educativo de enfermagem – destaque para grupos informativos; Aconselhamento como prática de cuidado de enfermagem - com atividades de orientação sobre infecções sexualmente transmissíveis; e Cuidado clínico de enfermagem - com foco em métodos contraceptivos. Conclusão: apesar de os enfermeiros ofertarem cuidados de enfermagem com foco na saúde reprodutiva, muitas vezes articulados com escolas e comunidade, há fragilidades com relação às orientações às mulheres lésbicas e a temas como fertilidade e infertilidade.
NATURALISASI FILSAFAT ISLAM DALAM PEMIKIRAN AL-GHAZALI
Authors: Assyabani Ridhatullah
Published: January 2023

The thought of al-Ghazali as outlined in Tahafut al-Falasifah has been a controversy for centuries and even today it has become a debate mainly related to the view of al-Ghazali who deconstructed the building of philosophy in Islam resulting in old wounds. In the end, various negative stigmas directed at al-Ghazali. However, whether the work of al-Ghazali, as many have suspected, has resulted in haunting in philosophy or just the opposite? By re-reading al-Ghazali as a traditionalist scholar and reviewing the general opinion which says that Tahafut al-Falasifah is a representation of the conflict between philosophy and dogma; or between orthodoxy and heterodoxy, this paper will show that al-Ghazali has an important role in naturalizing science and philosophy in the frame of Islamic theology.Pemikiran al-Ghazali yang tertuang pada Tahafut al-Falasifah menjadi kontroversi selama berabad-abad, bahkan hingga saat ini menjadi perdebatan terutama terkait dengan pandangan al-Ghazali yang mendekonstruksi bangunan filsafat dalam Islam mengakibatkan luka lama. Pada akhirnya berbagai macam stigma negatif yang ditujukan kepada al-Ghazali. Namun, apakah karya al-Ghazali tersebut seperti banyak yang diduga, telah mengakibatkan kehancuran dalam fisafat atau justru sebaliknya? Dengan melakukan pembacaan ulang terhadap al-Ghazali sebagai ulama tradisionalis dan meninjau pendapat umum yang mengatakan bahwa Tahafut al-Falasifah merupakan representasi konflik antara filsafat dan dogma; atau antara ortodoksi dan heterodoksi, tulisan ini akan memperlihatkan bahwa al-Ghazali memiliki peran penting dalam melakukan naturalisasi filsafat dalam bingkai teologi Islam.