bluuebunny/crossref_metadata_2025 huggingface dataset:
DETERMINANTES SOCIAIS DA SAÚDE: IMPACTOS NO DESENVOLVIMENTO DE CRIANÇAS E ADOLESCENTE EM SITUAÇÕES DE RISCO
Authors: Justino Neila Fernandes , Gomes Rebecca Nascimento da Silveira , Carminatti Micheli , Barros Luís Felipe Morais , Guerra Júlia Maria López , Rodrigues Jefferson Carlos Tolentino , Lopes Juliana de Fatima da Conceição Veríssimo , Anjos Jalmes Silva Pereira dos
Published: February 2025

Esse artigo buscou analisar os principais determinantes sociais da saúde (DSS) e seus impactos no desenvolvimento de crianças e adolescentes em situação de risco, destacando as implicações para a saúde pública e possíveis estratégias de intervenção. O trabalho avaliou, por meio de uma revisão integrativa da literatura, como fatores como pobreza, violência, insegurança alimentar, precariedade habitacional e acesso limitado a serviços de saúde e educação influenciam negativamente o crescimento físico, cognitivo, emocional e social desses indivíduos. A revisão evidenciou que a exposição a ambientes adversos está associada a maiores riscos de transtornos psicossociais, dificuldades de aprendizagem e desenvolvimento de doenças crônicas, perpetuando desigualdades e ampliando vulnerabilidades. Além disso, a pandemia de COVID-19 exacerbou esses desafios, reforçando a necessidade de políticas públicas intersetoriais que promovam equidade e inclusão social. O estudo concluiu que, embora os DSS representem um desafio significativo, a adoção de medidas estratégicas, como o fortalecimento de redes de apoio comunitário e a ampliação do acesso a serviços essenciais, pode mitigar seus efeitos negativos,  garantindo um desenvolvimento mais saudável e equitativo para crianças e adolescentes em situação de risco.
Arctic supraglacial lake derived bathymetry combining ICESat-2 and spectral stratification of satellite imagery
Authors: Lv Jinhao , Gao Chunchun , Qi Chao , Li Shaoyu , Su Dianpeng , Zhang Kai , Yang Fanlin
Published: February 2025

Abstract. Arctic supraglacial lakes volume changes serve as critical indicators of global temperature fluctuations. Accurate lake depth measurements are essential for reliable volume estimation, yet traditional bathymetry methods (e.g., airborne LiDAR and shipborne sonar) face significant challenges and high costs in the harsh Arctic environment. This study introduces a novel approach using ICESat-2 (Ice, Cloud, and Land Elevation Satellite-2) and Sentinel-2 data to derive supraglacial lake bathymetry. By considering the varying reflectance characteristics across different spectral bands in the water column, we conduct a satellite-derived bathymetry (SDB) method based on spectral stratification using the Otsu algorithm (maximum between-class variance method). Integrating the spectral stratification method with the classical log-transformed linear regression model (Lyzenga model), we perform accurate bathymetric inversion on multispectral satellite imagery. To verify the effectiveness of the proposed method, we apply it to four representative lakes on the Greenland Ice Sheet (GrIS), using ArcticDEM (Arctic Digital Elevation Model) as reference data. Experimental results demonstrate improved accuracy compared to the classical Lyzenga model, with reductions in root mean square error (RMSE) and mean absolute error (MAE) by up to 13.0 % and 14.0 %, decreasing from 0.54 m to 0.47 m and from 0.43 m to 0.37 m, respectively. The enhanced accuracy and scalability of our approach improve the ability to monitor large-scale volume changes in Arctic supraglacial lakes, providing valuable insights into their response to climate change.
Development of a regional probabilistic seismic hazard model for Central Asia
Authors: Poggi Valerio , Parolai Stefano , Silacheva Natalya , Ischuk Anatoly , Abdrakhmatov Kanatbek , Kobuliev Zainalobudin , Ismailov Vakhitkhan , Ibragimov Roman , Karaev Japar , Ceresa Paola , Santulin Marco , Bazzurro Paolo
Published: February 2025

Abstract. Central Asia is an area characterized by complex tectonic and active deformation, largely due to the relative convergent motion between India–Arabia and Eurasia. The resulting compressional tectonic regime is responsible for the development of significant seismic activity, which, along with other natural hazards such as mass movements and river flooding, contributes to increased risk to local populations. Although several studies have been conducted on individual perils at the local and national levels, the last published regional model for the whole of Central Asia, developed under the EMCA (Earthquake Model Central Asia) project, is almost 10 years old. With the goal of developing a new comprehensive multi-risk model that is uniform and consistent across the five Central Asian countries of Kazakhstan, the Kyrgyz Republic, Tajikistan, Turkmenistan, and Uzbekistan, the European Union, in collaboration with the World Bank and the Global Facility for Disaster Reduction and Recovery (GFDRR), funded the regional programme SFRARR (Strengthening Financial Resilience and Accelerating Risk Reduction in Central Asia). The activity was led by a consortium of scientists from international research institutions, from both the public and the private sectors, with contributions from experts of the local scientific community. This study presents the main results of a probabilistic seismic hazard analysis (PSHA) conducted as part of the SFRARR programme to develop the new risk model for Central Asia. The proposed PSHA model was developed using state-of-the-art methods and calibrated based on the most up-to-date information available for the region, including a novel homogenized earthquake catalogue compiled from global and local sources and a database of active faults with associated slip rate information.
Divisor equitably strong non-split divisor equitable domination in graphs
Authors: G. B. Priyanka , P Xavier , John J. Catherine Grace
Published: February 2025

In epidemiology, the spread of diseases can be modelled using graphs, where individuals are nodes, and edges represent potential pathways for disease transmission. A non-split dominating set could help identify key individuals (or groups) whose monitoring or immunization would ensure that the rest of the population (the non-dominated group) remains connected and can be controlled in case of disease spread. This approach has the potential to have a significant impact across various areas of medicine. We present the idea of non-split divisor equitable domination in graphs as a way to optimize medical networks. Let Q be a graph with vertex set R(Q) and edge set E (Q). Two vertices  h and  t  are known as degree divisor equitable if gcd(dQ(h), dQ(t)) = 1. F ⊂ R(Q) is known as divisor equitable dominating set of Q if ∀ h ∈ R\F, ∋ a t ∈ F such that h and t are adjacent and degree divisor equitable. The divisor equitable domination number of a graph γde(Q) of Q is the minimum cardinality of a divisor equitable dominating set of Q. In this paper, we introduce the concept of a non-split divisor equitable dominating set, divisor equitably strong non-split divisor equitable dominating set, and divisor equitable independent set and divisor equitable clique number. It also explores the concepts of a divisor equitable vertex dominating set, complement divisor equitable graph, and divisor equitable vertex cut.
Roman noir et activisme politique : figures croisées du militant dans le polar français
Authors: Campagna Julien
Published: February 2025

Le roman noir est, selon Jean-Patrick Manchette, un roman de la « misère politique » : il se doit de désespérer son lectorat. Le polar français de la deuxième partie du XXe siècle, ou néo-polar, peut ainsi se lire comme le foisonnant récit d’une désillusion politique, et comme la mise en déroute du modèle jugé par lui désuet de la littérature engagée. Alors que faire du roman noir lorsqu’il s’attaque précisément à la figure de l’activiste politique ? Il s’agit de réfléchir à l’écriture de l’activisme dans quatre romans noirs français représentants ou héritiers du néo-polar : Meurtres pour mémoire de Didier Daeninckx, C’est toujours les autres qui meurent de Jean-François Vilar, Le Bloc de Jérôme Leroy et Pire que la nuit de Sylvain Forge. Ceux-ci mettent en scène le militantisme pour observer comment le réconcilier ou le mettre en tension avec ce mépris de la littérature engagée affiché par les tenants du néo-polar. Est-il possible d’écrire sur l’activiste sans en devenir un soi-même ? Peut-on faire du militant une figure romanesque tout en refusant l’héroïsation ou la prise à parti morale ? Comment intégrer cette figure à une narration policière sans la spectaculariser, l’instrumentaliser ou la trahir ? L’intérêt de notre corpus est qu’il place au centre la question de l’action politique tout en la mettant à distance et en la soumettant au regard fondamentalement désespéré et froid du roman noir. Sa fiction s’ancre par ailleurs dans des espaces sociaux, idéologiques et temporels bien différents. La question du témoignage politique avec le FLN chez Daeninckx se prolonge naturellement dans l’écriture des derniers soubresauts du communisme chez Vilar quand les travaux de Leroy et Forge interrogent des modes d’activisme à l’actualité plus brûlante encore : le militantisme d’extrême-droite pour le premier et écologiste pour le second.
Optimizing pre-design research quality system to enhance construction safety
Authors: Polcanov Vladimir , Polcanova Alina , Rascovoi Alexandru , Cirlan Alexandru
Published: February 2025

The article examines factors influencing the safety of the geological environment. Unfavorable processes leading to disruption of the natural balance and affecting the safety and durability of buildings and structures are identified. The need for engineering and geological surveys, as outlined in regulatory documents, is emphasized, highlighting the essential involvement of certified geotechnical specialists and accredited laboratories. The article specifically highlights that there is a growing need for greater attention to the composition and quality of surveys conducted in densely built environments. It has been proven that timely implementation of environmental protection measures allows optimizing costs and the overall cost of an investment project.
Analysis of sustainable development practices in the European Union: a perspective on achieved successes and encountered challenges
Authors: Oberst Ala
Published: February 2025

The article examines the global and European context of sustainable development, addressing both achievements and challenges in implementing this integrative concept. The adoption of international frameworks, such as the 2030 Agenda and the Paris Agreement, has established a shared foundation for mobilizing government and private sector efforts toward a balanced transition across economic, social, and environmental dimensions. The European Union (EU) positions itself as a central global actor in promoting sustainability through initiatives like the European Green Deal and the Biodiversity Strategy for 2030. However, their implementation faces significant challenges, including the intensification of climate change, economic pressures, social disparities, and the reconfiguration of global supply chains. Alongside remarkable progress in reducing greenhouse gas emissions and advancing the circular economy, deficiencies persist in waste management, biodiversity conservation, and energy infrastructure expansion. This paper highlights the need for integrated approaches tailored to national specificities to achieve sustainable development goals and strengthen cohesion at both European and international levels.
Directions for improving management methods in the construction sector
Authors: Cucos Stela
Published: February 2025

Currently there is an objective need to select and justify the optimal investment scheme in the construction industry. One of the options is the development and introduction of the investment management system at the regional level. Concept of the construction complex effective functioning should be based on the gradual change in a positive direction of the growth rate of investment in basic capital. It aims to achieve tangible results, for which, through an action plan, concrete measures are established. In the context of the quantifiable fixation of the desired results, the action plan ensures an increased degree of managerial flexibility in identifying and promoting optimal solutions to ensure a sustainable developments of the construction sector. The implementation of this concept is essential to the modernization and renovation of industrial innovation capacity of the national economy.
ЦИФРОВИЗАЦИЯ ПЛАНИРОВАНИЯ ПРОЦЕССА ПРОЕКТИРОВАНИЯ МАЛОЭТАЖНЫХ ЗДАНИЙ С УЧЕТОМ КАЧЕСТВА ВНУТРЕННЕГО ВОЗДУХА
Authors: Ometova Mariya Yuryevna , Zaytseva Irina Aleksandrovna , Loginova Svetlana Andreyevna , Levitskiy Semyen Vasilyevich , Basov Aleksandr Nikolayevich
Published: February 2025

В статье подробно разбирается роль цифровой трансформации в строительной индустрии, в частности, применение технологий информационного моделирования, таких как BIM (Building Information Modeling), для улучшения процессов проектирования и строительства. Основное внимание уделяется важности качества воздуха внутри зданий. Обосновывается использование цифровых технологий и программных продуктов с целью более точного и эффективного планирования, учитывая множество параметров, включая энергоэффективность, структурную надежность и особенно качество внутреннего воздуха. Авторами представлена принципиальная схема организации проектирования и строительства, в которой цифровизация играет ключевую
роль в координации и оптимизации всех процессов. Сформулированы рациональные направления для дальнейшего развития и углубления цифровизации в строительных процессах, подчеркивая ее значимость для создания здоровой и устойчивой среды в малоэтажных жилых зданиях.
ИССЛЕДОВАНИЕ ВЛИЯНИЯ КОМПЛЕКСНОЙ НАНОДОБАВКИ НА ОСНОВЕ ФТОРИСТЫХ СОЛЕЙ НА ПРОЧНОСТНЫЕ ХАРАКТЕРИСТИКИ ЦЕМЕНТНЫХ БЕТОНОВ
Authors: Loginova Svetlana Andreyevna , Tanichev Maksim Vladimirovich , Kalinin Aleksey Vyacheslavovich , Goglev Ilya Nikolayevich
Published: February 2025

В статье представлены данные первого этапа исследования (неразрушающего контроля по ГОСТ 22690-2015) прочности цементных бетонов после введения в них комплексной нанодобавки – ускорителя твердения на основе неорганических фторсодержащих солей. Состав добавки и величина помола (нанокристаллический уровень) позволяют ускорить процесс упрочнения цементного камня благодаря раннему сращиванию зерен и образованию нерастворимых, плотных соединений (продуктов реакции) в порах цементного камня. Результаты первого этапа показали низкий расход добавки: на 1 м3 тяжелого бетона на уровне 0,015–0,02 от его массы, а прирост прочности после введения добавки составил 44,99 % по сравнению с обычным бетоном. Полученные данные влияния предлагаемой добавки на основе смеси нанопорошков фторборатных и флюатных солей на свойства бетонной смеси позволяют сделать вывод о ее высокой эффективности.
ВЛИЯНИЕ СОСТАВА МОДИФИЦИРОВАННЫХ И ПОЛИМЕРНО-БИТУМНЫХ ВЯЖУЩИХ НА ТЕХНИЧЕСКИЕ ПОКАЗАТЕЛИ ЩЕБЕНОЧНО-МАСТИЧНЫХ АСФАЛЬТОБЕТОННЫХ СМЕСЕЙ
Authors: Isenbulatova Dilyara Khaydarovna , Yefremov Ivan Aleksandrovich , Lushnikov Nikolay Aleksandrovich , Nebratenko Dmitriy Yuryevich , Aleksikov Sergey Vasilyevich
Published: February 2025

На современном этапе развития дорожно-строительной отрасли в России существенное внимание уделяется постоянному совершенствованию компонентного состава асфальтобетонных смесей. Таким образом можно существенно улучшить как технологические свойствам асфальтобетонных смесей, так и эксплуатационные показатели покрытий. Одним из вариантов таких передовых типов покрытий является щебеночно-мастичный асфальтобетон. Верхний слой дорожного покрытия, получающийся в случае формирования из щебеночно-мастичных асфальтобетонных смесей, характеризуется комфортными и безопасными ездовыми качествами, а образующаяся текстура отличается повышенной шероховатостью и способностью поглощать шум, образующийся при движении транспортных средств. Поэтому в данном исследовании проведено сопоставление основных показателей щебеночно-мастичных смесей, изготовленных с применением вяжущих различного состава. Показано, что
все составы удовлетворяют требованиям ГОСТ Р 58406.1-2020 по испытанным показателям.
АНАЛИЗ ФАКТОРОВ ШУМОВОГО ЗАГРЯЗНЕНИЯ И ЗАЩИТА ОТ ШУМА В МЕГАПОЛИСАХ
Authors: Korniyenko Sergey Valeryevich , Sinkevich Polina Valeryevna , Sinkevich Georg Georgiyevich
Published: February 2025

Доказано, что стремительный рост городского населения приведет к значительному шумовому загрязнению урбанизированных территорий, что актуализирует проблему защиты от шума и необходимость создания комфортной безопасной городской среды. Раскрыты основные факторы шумового загрязнения урбанизированных территорий. Показано, что главным источником загрязнения мегаполисов является транспортный шум. На основе новой концепции «город как единая акустическая система» систематизированы меры по снижению уровня шума городского транспорта: в источнике, на пути распространения, в зданиях. С целью повышения эффективности мероприятий по снижению шума в городской среде намечены главные преимущества
интегрирования в городскую среду альтернативных транспортных средств нового поколения: гибридных,
электробусов и на водородном топливе.
Création of Medicinal Substance-Related Nitrosamine Exposerai Contaminants in Therapeutics
Authors: Shukla Shashank Lavkush , Behere Sudarshan E.
Published: February 2025

The use of N-nitrosamines, especially in the médical field, raises questions regardant global safety due to their hazardous and mutational properties. This comprehensive review looks at the technology, management, analysis, and biological consequences of nitrosamines in medical, pharmaceutical, and analgesic applications. This review discusses the atomic dangers associated with N-nitroso compounds, specifically focusing on DNA damage, DNA mutation, cancer prevention, and other related effects. Concerns about nitrosamine risk, the development of nitrosamine-free products, the importance of risk assessment, and diagnostic methods are also highlighted. A comprehensive review will benefit professionals working to lessen the harm caused by nitrosamines and improve the safety of medications, such as biologists, doctors, manufacturers, scientists, and engineers. The permissible limit for N-nitrosamine has been exceeded in clinics. Drug shortages resulted from the withdrawal or discontinuation of the anti-diabetic medication rifampicin and the medication metformin. Regrettably, the amines N in items also impede the creation of novel medications. Because of nitrogen dioxide damage, government bodies prohibit the use of a drug called in human drug relationship (DDI) investigations. One of the primary medications used in these investigations is rifampin. Drug makers are now compelled to act.
Quantam Dots and their Medical Importance
Authors: Hande Atharva Vinod , Maner Saddam Shamshudin , Jadhav Pranoti Pralhad , Kamble Deepti Dharmendra
Published: February 2025

Quantum dots (QDs) are semiconductor material that have gained great interest due to their unique characteristics like optical properties. QDS are a revolutionary new technology that is being used to treat a variety of diseases. The excretion of QD indicates conversion in natural imaging along with photography have established incredible suitability in bioimaging, new drug development, targeted gene deliverance, biosensing, photodynamic treatment as well as diagnosis. Cancer is a major threat to public health in 21st century because it is one of the leading causes of death. With the optical and chemical advantages of QD, QD -based nanotechnology is helpful in constructing a biomedical imaging platform for cancer behavior study. Also detecting viral infections has become challenging in medical research due to their high infectivity and mutation. Detection viruses based on quantum dots biomarkers is inexpensive and has great potential. Nanotechnology is an emerging field that may have potentials as make in the detection treatment and prevention of cancer. Quantum dots used to detect primary tumor. Also be take part in the treatment of breast cancer in women in which diagnosis of breast cancer, detection of correlation between HER2 gene amplification and protein expression, immunofluorescence imaging of HER2 and ER, triple negative breast cancer therapy using QDs based micelle conjugation. The blood brain barrier (BBB) protects the blood tissue. Only certain small molecule like water and gases can BBB, whereas large molecule entre via receptors, but many drugs are incapable of passing the barrier.
Time series analysis and forecasting in finance: A data mining approach
Authors: Afiz Adewale Lawal  , Omogbolahan Alli  , Aishat Oluwatoyin Olatunji  , Enuma Ezeife  , Ehizele Dean Okoduwa
Published: February 2025

Time series analysis and forecasting are essential methodologies in finance, playing a pivotal role in predicting market trends, evaluating economic conditions, and supporting decision-making. These methods rely on analyzing sequential data to uncover patterns, trends, and seasonal variations that drive financial phenomena. Traditional statistical models, such as ARIMA and GARCH, have long been utilized; however, their effectiveness is often constrained by assumptions like linearity and stationarity. Recent advancements in data mining techniques, including machine learning and artificial intelligence, have transformed the landscape of time series forecasting. These innovative approaches excel at handling non-linear relationships, high-dimensional data, and noise inherent in financial markets, making them indispensable for modern financial analytics. This paper scours the concept of time series analysis and data mining, examining their integration to improve forecasting accuracy. Additionally, it evaluates challenges such as data quality and computational requirements, while highlighting emerging opportunities, such as real-time forecasting and big data applications.
From Theory to Practice: The Impact of Team-Based Learning on Medical Students’ Communication Skills
Authors: Pires Elda Maria Stafuzza Gonçalves , Meeuwissen Stephanie N. E. , Savelberg Hans H. C. M.
Published: February 2025

Introduction: Developing communication skills is essential for medical students to work in modern medical practice. A collaborative learning environment, such as Team-Based Learning (TBL), is a promising environment for developing communication skills. In this study, we investigated 1) how medical students self-report their communication skills in a TBL environment and 2) to what extent students perceive a TBL environment as contributing to their communication skills development.
Method: We conducted a quantitative study with a qualitative element involving Brazilian undergraduate medical students from one Medical School. Participants completed the Interpersonal Communication Competence Scale and the Team-Based Learning Environment Scale, including an open-ended question. We used ANOVA to compare responses across the seven semesters and thematic analysis for the open-ended responses.
Results: Of the 416 students invited, 307 (74%) responded to both scales. Students had high scores on communication skills. Students highly valued the contribution of five domains of the TBL learning environment: teachers’ decisions, teachers’ attitudes, students’ characteristics, team characteristics, and contextual factors. The sixth domain, formative assessment, was highly valued by first-year students with a downward trend across semesters. Key factors contributing to communication skills development were teachers’ alignment with the educational methodology and students’ attitudes within teams. Additionally, students noted that their perception of safety and trust to provide feedback influenced their communication skills development.
Conclusion: These findings suggest that a TBL environment can maintain students’ communication skills. Various elements of the TBL environment play a role here, particularly teachers’ alignment, students’ attitudes, and a supportive classroom atmosphere.
Rezension von: Der jüdische Frisör ...
Authors: Schönhagen Benigna , Tāmîr Arnôn , Uhlman Fred
Published: February 2025

Der jüdische Frisör. Auf Spurensuche: Juden in Stuttgart-Ost. Herausgegeben von der Stuttgarter Osten Lokalzeitung.Silberburg Verlag Tübingen und Stuttgart1992. 128 Seiten mit 50 Abbildungen. Broschiert DM 16,80
Arnon Tamir: Eine Reise zurück. Von den Schwierigkeiten,Unrecht wiedergutzumachen. (Lebensbilder. JüdischeErinnerungen und Zeugnisse, Band 5.) Frankfurtam Main (Fischer Taschenbuch) 1992. KartoniertDM 14,90
Fred Uhlman: Erinnerungen eines Stuttgarter Juden.Aus dem Englischen übersetzt und herausgegeben vonManfred Schmid. (Veröffentlichungen des Archivs derStadt Stuttgart, Band 56). Klett-Cotta Stuttgart 1992.203 Seiten mit 18 Abbildungen. Gebunden DM 29,80
Rezension von: Knorr, Birgit, Wehling, Rosemarie (Hrsg.), Frauen im deutschen Südwesten
Authors: Rothmund-Gaul Gabriela , Knorr Birgit , Wehling Rosemarie
Published: February 2025

Birgit Knorr und Rosemarie Wehling (Hrsg.): Frauen imdeutschen Südwesten. (Schriften zur politischen LandeskundeBaden-Württembergs, Band 20). Verlag W. KohlhammerStuttgart 1993. 309 Seiten mit 31 Abbildungen.Halbleinen DM 39,80
Rezension von: Rauch, Udo (Hrsg.), Zwischen Ammer und Neckar
Authors: Faix Gerhard , Rauch Udo
Published: February 2025

Udo Rauch (Hrsg.): Zwischen Ammer und Neckar. DasTübinger Stadtbild im Wandel. (Tübinger Kataloge,Band 42). Stadt Tübingen, Kulturamt 1994. 188 Seiten mit177 Abbildungen. Pappband DM 32,-
Exploration of antioxidant metabolites in Minnie root (Ruellia tuberosa L.) leaves
Authors: Juswardi Juswardi  , Nur Salamah  , Nina Tanzerina  , Kamila Alawiyah  , Endri Junaidi  , Hanifa Marisa
Published: February 2025

Minnie root (Ruellia tuberosa L.) is a medicinal plant known for its various therapeutic uses. The leaf extract of Minnie root contains secondary metabolites like alkaloids, flavonoids, triterpenoids, steroids, and saponins, which exhibit antidiabetic, antibacterial, and antioxidant properties. This study aims to analyze the abundance of metabolite compounds, antioxidant levels, and antioxidant metabolites in Minnie root leaves using GC-MS analysis. Additionally, the study explores the antioxidant metabolites present in the ethanol extract of Minnie root leaves through various online databases. The results revealed that the ethanol extract of Minnie root leaves contained 17 compounds, with 9 of them identified as antioxidant metabolites, constituting 72.38% of the total compounds. Some of the antioxidant bioactive compounds identified include D-limonene and 5-hydroxymethylfurfural. The antioxidant concentration in Minnie root leaves was measured at is 99.480 ± 8.224 ppm using ascorbic acid standards and 133.500 ± 7.912 ppm using quercetin standards. Further research is necessary to explore other potential bioactivities of Minnie root leaf metabolites, such as their antidiabetic properties, for developing herbal medicines.
Pathogenesis of Acne Vulgaris and New Therapeutic Progresses
Authors: Mao Zishu
Published: February 2025

Acne vulgaris (AV) is a prevalent inflammatory skin condition that bothers a range of people, appearing in lots of areas of our body. This paper examines the various factors contributing to AV development, including hormone levels, dietary influences, environmental triggers, and stress-related pathways. Through analyzing recent findings on topical and oral drug therapies, as well as non-invasive treatments such as photodynamic therapy, the study identifies key treatments that reduce different levels of AV and AV scars. Additionally, the paper discusses the promising results of combining vitamin C and vitamin A (or retinoid) products ("morning C, evening A") for their antioxidative and scar-reducing properties. By synthesizing these findings, this study is looking forward to future AV research, focusing on the multi-faceted approach that considers the impact of lifestyle and psychological health. Future research could benefit from investigating the molecular mechanisms underlying these combined treatments and developing more targeted therapies to minimize side effects while effectively addressing the underlying causes of AV.
Advances in the Development of Ubiquitination Pathway Targets for the Treatment of Tumours
Authors: Qian Junda
Published: February 2025

In recent years, oncology research has made great progress, but malignant tumours still become a great threat to human health, and many cancer treatments as well as targeted drug therapy for cancer have been developed, which can largely inhibit the development of cancer cells and even cure cancer. The research related to ubiquitination in cancer therapy research is also increasing year by year. Ubiquitination plays a very important role in protein localisation, metabolism, function, regulation and degradation. This also means that ubiquitination has a very important role in the treatment of tumour-related targets. This paper analyses the control of the ubiquitination pathway through the use of specific small molecule inhibitors. Such small molecule inhibitors inhibit a range of deubiquitinating enzymes so that negatively regulated proteins in the target molecule can be normally ubiquitinated and degraded, and t-cells can normally recognise and suppress tumourigenesis. Research into the effects of small molecule inhibitors on the ubiquitination pathway is making great progress today, which will be of great help in the future treatment of tumours. At the same time, the synergistic delivery of this approach with existing targeted drugs is also an important direction for future development that needs to be investigated.
Cardiotoxicity in Cancer Immunotherapy: Pathological and Future Directions
Authors: Lu Runyang
Published: February 2025

Cancer and its complication remain one of the most popular and serious neoplasia disease in the domain of medicine. Although more and more immunotherapies have been developed and put into use, there still exist many unknown issues waiting to be explored in the laboratory and clinical application. Cardiotoxicity is one of the complex side effect of some active immunotherapies and may bring negative treatment issues for patients have heart disease in the past times and those at risk of developing heart disease. This review analyse the pathological manifestations and specific mechanisms of cardiac side effects caused by different tumor immunotherapies are presented, along with existing drug and non drug response measures and patient education. This review find the myocarditis caused by immune inflammation could be the vital relation between immunotherapy and cardiac functions. This study can provide medical direction and patient education reference for future research on the side effects of cancer immunotherapy. However, there is insufficient medical theories of the related effects of the immune system and tumor blood vessels. Future research can focus more on the reaction between some antigen antibody cancer vaccine drugs and the immune system.
ANALIZA RELEVANTNOSTI NAČINA PLAĆANJA PRILIKOM ODABIRA TURISTIČKIH ARANŽMANA PUTEM PRIMENE METODE SKOROVA SKLONOSTI
Authors: Petrović Marina , Hristov Stančić Branislava , Čolić Lazar
Published: February 2025

Apstrakt. Proces donošenja odluka u vezi sa odabirom turističkih arnžamana je prošao značajan razvojni put poslednjih decenija. Internet i meta pretražni sistemi doprineli su brzini i lakoći dobijanja relevantnih informacija što je uslovilo da pojedinac često zaobilazi stručne posrednike i samostalno vrši odabir različitih elemenata putovanja. Međutim, ovaj proces istovremeno može biti veoma interesantan ali iscrpljujuć, kako putnici prolaze kroz brojne opcije u potrazi za idealnom kombinacijom destinacija, aktivnosti i smeštaja. Prilikom donošenja odluka o kupovini turističkog aranžmana ili njegovih elemenata, pojedinac u razmatranje uzima veći broj činjenica i donosi odluku u skadu sa svojim preferencijama i mogućnostima. Različliti faktori mogu biti krucijalni za donošenje odluka o izboru turističkog aranžmana, pa je tako cilj ovog rada da pokaže da način plaćanja turističkih aranžmana više utiče na odabir aranžmana u slučaju studenata doktorskih studija ekonomskih nauka nego studenata nižih nivoa studija. Testiranje je podrazumevalo ocenjivanje regresionog modela gde su se koristili ponderi dobijeni primenom metode skorova sklonosti (engl. propensity score) za balansiranje eksperimentalne i kontrolne grupe. Za balansiranje u modelu je korišćen Švarcov tip ličnosti. Na osnovu rezultata analize zaključeno je da je studentima doktorskih studija ekonomskih nauka prilikom donošenje odluke o odabiru turističkih aranžamana varijabla način plaćanja važnija nego što je to slučaj kod studenata osnovnih i master studija.
An Exploration of the Strategies for Students' Silence in Junior High School English Classes
Authors: Pei Yanjun
Published: February 2025

In the context of the ongoing globalization, English, as a crucial tool for international communication, plays a significant role in various fields such as economy and culture. However, in current junior high school English teaching in China, the phenomenon of classroom silence is widespread. This not only hinders the improvement of students' English communication skills but also runs counter to the goals of modern Chinese education. This paper analyzes the causes of classroom silence in English classes and attempts to propose improvement methods and countermeasures, aiming to contribute to the enhancement of the teaching efficiency of English classes.
The Role of Hydroponics in Sustainable Agriculture and Water Conservation in India
Authors:   Professor, MBA, Faculty of Management Studies, CMS Business School,  JAIN(Deemed-to-be-University) Bangalore, India, kumar Dr Navaneetha
Published: February 2025

The Indian economy relies heavily on agriculture, which accounts for around 17-18% of the GDP and engages almost 44% of the labour force. Yet, the very important sector is under immense pressure from reasons like land degradation, unpredictable climatic conditions, dwindling water resources, and increasing food needs. Conventional farming practices, which are dependent on soil and intensive irrigation, have resulted in excessive use of natural resources, leading to long-term environmental degradation. Considering the growing demand for sustainable agriculture, hydroponics is proving to be a viable option to counter food security and water conservation issues in India.

Hydroponics is a soilless cultivation method where plants are grown in a water solution containing nutrients rather than soil. This new agricultural practice provides increased crop yields, effective use of resources, and less water usage than traditional farming. Hydroponics eliminates soil problems like nutrient loss, pests, and soil erosion, thus providing improved productivity in a controlled environment.

In India, where 70% of freshwater is consumed in irrigation, and water scarcity is a common problem in many areas, hydroponics can transform agriculture with the potential to conserve water up to 90%. Hydroponic systems can also be used in cities, rooftops, and wastelands, bringing farming within reach and making it sustainable in areas where conventional farming is not viable.
FEATURES OF THE FORMATION OF HAIR AND SKIN STRUCTURE IN BULLS OF DIFFERENT BREEDS DEPENDING ON AGE AND SEASON OF THE YEAR
Authors:   Bashkir State Agrarian University, Gazeev Igor R. , Karamaev Sergey V. ,   Samara State Agrarian University, Tagirov Hamit Kh. ,   Bashkir State Agrarian University, Karamaeva Anna S. ,   Samara State Agrarian University
Published: February 2025

The purpose of the research is to scientifically substantiate the change in the hair cover of bulls of different productivi-ty directions depending on age and season of the year. Performing a heat-protective function, the hair cover of cattle changes with the age of animals, most of all according to the seasons of the year as a result of spring and autumn molting. In this regard, it is necessary to know what factors influence these changes, what changes occur in the mor-phological structure of the skin and its derivatives. To achieve this goal, three groups of 15 heads each were formed from newborn bulls of black-and-white, Bestuzhev and Kalmyk breeds at the livestock complexes of the Republic of Bashkortostan and the Samara region. Hair quality, histological and morphological structure of the skin were studied in experimental animals aged 8, 12, 18 months. It was found that at the age of 8 months, the thickest wool was in Calmy bulls. At the age of 12 months, after the change of winter hair cover to summer, the density decreased in ani-mals of group I by 480 pcs./ cm2 (35.6%), group II – by 671 pcs./ cm2 (42.9%), group III – by 537 pcs./ cm2 (31.8%). By the age of 18 months, after the autumn molt, the density increased again, respectively, by 601 pcs./ cm2 (69.3%); 833 pcs./ cm2 (93.3%); 646 pcs. / cm2 (56.1%). Histological studies of the skin have shown that the signs characteriz-ing the quality of the hair cover are due to differences in the structure of the skin, as well as the number and location of the glands of the skin. Therefore, when choosing the method of keeping bulls, it is necessary to take into account these features of the skin and hair of the studied breeds.
REPRODUCTIVE ABILITIES OF COWS AND THE QUALITY OF NEWBORN CALVES DURING PUREBRED BREEDING AND CROSSING OF KALMYK AND MANDOLONG BREEDS
Authors:   Bashkir State Agrarian University, Negmatov Khayridin M.
Published: February 2025

The purpose of the research is to assess the reproductive ability of cows and the quality of newborn calves during purebred breeding and crossing of Kalmyk and Mandolong breeds of beef cattle. The study of the influence of the method of purebred breeding and crossing of Kalmyk and Mandolong breeds of beef cattle on the reproductive abili-ties of cows and the quality of newborn calves was carried out in the conditions of the farm «IP Bugaeva V.S.» of the Samara region. The research materials were Kalmyk and Mandolong cows and their first-generation crossbreeds, as well as newborn calves on the first day after birth. In newborn calves of the Kalmyk and Mandolong breeds, as well as first- and second-generation calves, the time of manifestation of the main physiological reactions was studied: getting on their feet, the manifestation of the sucking reflex, consumption of the first portion of colostrum, the volume of colostrum consumed relative to the live weight of the calf. It was found that due to the large difference in live weight in cows and bulls during interbreeding, crossbreed calves of the first generation were born large – 7.05-7.94% rela-tive to the live weight of the mother, as a result, the proportion of calving with complications was 20.0%. Calves born during calving with complications adapt more slowly to environmental conditions, their physiological activity is weaker. The first portion of colostrum was consumed by crossbred bulls from the problem group later than the physiological norm by 9.3-15.4 minutes in volume, relative to their live weight, less by 1.60-1.66% (P<0.001). Therefore, to cross Kalmyk and Mandolong breeds, in order to avoid difficult calving, it is necessary to select only full-aged, well-developed, with a high live weight cows of the Kalmyk breed.
Soms moet er iets gebeuren voordat er iets gebeurt
Authors: Houdijk J.C.A. , Snoek M.A.M.
Published: February 2025

Soms moet er iets gebeuren voordat er iets gebeurt. De implicaties van de arresten in European Superleague, ISU en Royal Antwerp voor de ontwikkeling van het Europees mededingingsrecht

Het Hof van Justitie heeft zich in een drietal spraakmakende sportarresten uitgelaten over een aantal aspecten van de toepassing van het mededingingsrecht op de (commerciële organisatie en exploitatie van de) sportsector, specifieker op de rol van sportbonden en -federaties in de regulering van de professionele sportsector. Het Hof van Justitie buigt zich in deze zaken over de ruimte die sportfederaties (waaronder voetbalbonden) hebben om besluiten te nemen over de mogelijke toetreding van nieuwe partijen tot de sportevenementenmarkt door middel van de introductie van nieuwe competitie- of wedstrijdvormen. Het Hof van Justitie formuleert een aantal voorwaarden waaraan sportfederaties zijn gehouden in de opzet van hun organisatie en reglementen voor de beoordeling van initiatieven tot nieuwe competitievormen of wedstrijden en voor de ter controle ingestelde sancties. Het gaat dan om de beginselen van transparantie, objectiviteit, non-discriminatie en evenredigheid.

HvJ 21 december 2023, C-333/21, ECLI:EU:C:2023:1011 (European Superleague Company SL/Fédération internationale de football association (FIFA) et Union des associations européennes de football (UEFA)); HvJ 21 december 2023, C-124/21 P, ECLI:EU:C:2023:1012 (International Skating Union/Europese Commissie); HvJ 21 december 2023, C-680/21, ECLI:EU:C:2023:1010 (UL en SA Royal Antwerp Football Club/Union royale belge des sociétés de football association ASBL).
A Look at The Military Aggression of The Soviet Union to Afghanistan (December 1979-February 1989)
Authors:   Assistant professor, Department of history, Faculty of social sciences at Parwan University, Parwan, Afghanistan, Mirzada Hekmatullah
Published: February 2025

The Soviet military invasion of Afghanistan in December 1979 is considered one of the most important political and military events in the contemporary history of Afghanistan as well as the Cold War era. This event not only turned Afghanistan into a proxy war scene between the superpowers of the East and the West; rather, it left extensive effects on regional and global security and stability. The importance and necessity of this research lies in examining the internal and external roots of this aggression, analyzing its consequences and understanding its long-term effects on the political, social and economic structures of Afghanistan and the region. The purpose of this research is to provide an analysis of the Soviet military aggression against Afghanistan. The findings of this research show that the internal political instability, the internal differences of the Afghan People's Democratic Party and the Soviet effort to maintain its geopolitical influence in the region were the main reasons for this aggression. Also, the consequences of this aggression included massive human casualties, the destruction of Afghanistan's infrastructure, and the increase in the influence of Mujahideen forces, the effects of which remained noticeable even decades later. On the other hand, this war played an important role in weakening the Soviet Union and its final collapse. The conclusion of this research emphasizes that foreign military interventions, regardless of the internal conditions of the target country, instead of achieving political goals, lead to instability and deeper crises. The Soviet invasion of Afghanistan is one of the outstanding examples of the failure of development policies, which is not only for the attacking country; It also had devastating consequences for the target country.
Perfil epidemiológico da meningite no Estado de Alagoas no período de 2019 a 2023
Authors: Alves Darah Yasmim Moreira , Ribeiro Maria Victoria de Morais Born , Lima Rodrigo Batista de , Barbosa Isadora Murta , Moreira Gabriel de Carvalho , Costa Luany Alves , Santana Júlia Mariana Santos , Vieira Izis Karoliny Ferreira , Souto Lidiane Ladeia Malheiros , Alves Hillary Keitelly Santos , Albuquerque Geórgia Maria Cavalcante de , Pereira Marília Rocha Lira , Alves Carolinne Cavalcante Pessoa
Published: February 2025

A meningite é caracterizada como uma inflamação das leptomeninges, sendo diagnosticada pela presença de um aumento anormal no número de leucócitos no líquido cefalorraquidiano. A meningite bacteriana é responsável por aproximadamente 250 mil óbitos anuais, conforme dados da Organização Mundial da Saúde (OMS). Essa doença tem potencial para desencadear epidemias de rápida propagação, resultando em um elevado impacto global. O objetivo deste estudo foi apresentar e analisar o perfil epidemiológico da meningite bacteriana no estado de Alagoas entre os anos de 2019 e 2023. Com isso, identificou-se um pico de casos em 2019, seguida por uma queda expressiva nos dois anos seguintes, influenciada pela pandemia de COVID-19, e um novo aumento em 2023. A faixa etária mais afetada foi de 20 a 39 anos, enquanto crianças entre 1 a 4 anos também apresentaram vulnerabilidade. O exame quimiocitopatológico foi o método diagnóstico mais utilizado, e a maioria dos pacientes evoluiu para alta hospitalar; geograficamente, Maceió concentrou 94% dos casos. Portanto, o fortalecimento da vigilância epidemiológica, a ampliação da cobertura vacinal e medidas eficazes de diagnóstico precoce são essenciais para minimizar o impacto da doença. A continuidade de estudos sobre a epidemiologia da meningite no estado é imprescindível para subsidiar políticas públicas mais eficientes no controle e prevenção da doença.
The Hope of Salvation for All in the Light of Contemporary Universalism
Authors: Lecuit Jean-Baptist
Published: February 2025

The arguments of contemporary universalists, who, like David B. Hart, follow Gregory of Nyssa and other Church Fathers in affirming that all human beings will be saved, are particularly powerful and open the possibility of reinterpreting the meaning and scope of traditional doctrine. They take into account the abundance and force of universalist verses in the New Testament, the difficulty of integrating damnation into the economy of salvation, the constitutive solidarity between all human beings, and the fact that if the final act leading to damnation is not carried out in all lucidity and freedom, its consequences are unjust, and if it is entirely lucid and free, it is impossible. The force of these arguments leads to a defence, not only, with Balthasar, of the possibility and the duty to hope for all, but of the extreme probability —and not the certainty— of the realisation of this hope. Finally, the pastoral stakes involved are assessed.
The New Mission of Theology According to Pope Francis
Authors: Gardocki Dariusz
Published: February 2025

The article focuses on presenting the new mission of theology according to Pope Francis. This novelty is primarily related to the missionary orientation of the Church and the definition of the Church as a community that is “on the way” and “setting out on the way” i.e. sent to all people and reaching out to the peripheries and places forgotten by the world. In this missionary orientation of the Church, Pope Francis sees the possibility of renewing theology, because theology is considered by him as a study that is at the service of the Church and its mission. Therefore, the Pope encourages theologians to do theology in the perspective of the Church’s missionary commitment in order to ensure that the theology they create is a reflection which reaches out to the “borders” and to the “peripheries”, as well as to the “entire cultures”. Hence theologians should seek new signs, new symbols and new ways of transmitting the Gospel, as well as they should enter into dialogue with other sciences to better explain the truth of faith and with concepts that today’s people can understand. The first point presents the challenges that, according to Pope Francis, contemporary theology faces. The second, in turn, discusses the tasks that it has to fulfill today. The summary presents the conclusions which result from the analysis of the papal documents devoted to the issue of the new mission of theology.