bluuebunny/crossref_metadata_2025 huggingface dataset:
A 78 dB 0.417 mW Second-Order NS SAR ADC with Dynamic Amplifier-Assisted Integrator
Authors: Cui Dingkang , Wang Zhihai , Jiang Mengqian , Chen Zhijie
Published: January 2024

The noise-shaping (NS) successive approximation register (SAR) analog-to-digital converter (ADC) is an innovative hybrid structure that offers performance advantages. The NS-SAR ADC leverages the SAR ADC as its foundation and combines oversampling technology and noise-shaping technology found in Sigma-Delta ADC. This integration effectively combines the strengths of both structures and enhances overall performance. The ADC features a simple circuit structure, compact chip area, and high energy efficiency, which has positioned it as a prominent research area. In this paper, leveraging the TSMC 65 nm GP process, the NS-SAR ADC is designed with a power supply voltage of 1 V. This design adopts an 8-bit differential capacitor structure, operates at a sampling frequency of 16 MS/s, and achieves an oversampling rate of 16 times the desired performance indicators. Through extensive circuit post simulation verification, the SNR obtained reaches 78 dB, providing an effective bit resolution of 12.7 bits. The core chip area of the ADC measures 366 × 333 μm2, while the power consumption is impressively low at 417 μW and FoMs is 168 dB.
Recognizing Complex Activities by Combining Sequences of Basic Motions
Authors: Lu Chenghong , Hsu Wu-Chun , Jing Lei
Published: January 2024

For daily motion recognition, each researcher builds their own method to recognize their own specific target actions. However, for other types of target motions, they cannot use their method to recognize other kinds of motions because the features of their target motions that they extracted cannot be extracted from other kinds of motions. Therefore, we wanted to develop a general method that can be used in most kinds of motions. From our observations, we found that a meaningful motion is combined with some basic motions. Therefore, we could recognize basic motions and then combine them to recognize a target motion. First, we simply defined the basic motions according to the sensor’s basic sensing directions. Second, we used k-nearest neighbors (KNN) and dynamic time warping (DTW) to recognize different categories of basic motions. Then, we gave each basic motion a specific number to represent it, and finally, used continuous dynamic programming (CDP) to recognize a target motion by the sequence of basic motions we collected. In our experiment on our basic motions, the accuracy of all of the basic motions is higher than 80%, so the recognition of basic motions is reliable. Then, we performed an experiment for recognizing the target motions. The results of recognizing the target motions were not good, the average accuracy being only 65.9%, and we still have to improve our system. However, we also compared our system with recognizing motions by using another general recognition method, KNN. And the average accuracy of using KNN to recognize motions was 53.4%. As this result shows, our method still obtains better results in recognizing different kinds of motions than using KNN.
Multibeam Cylindrical Conformal Array in the Presence of Enhanced Mutual Coupling
Authors: Lv Xianyang , Zhang Yongwei , Shi Quan , Fu Yanwei , Temiz Murat , El-Makadema Ahmed , Li Hongliang
Published: January 2024

The limitations of conventional sensors have made array antennas increasingly crucial for gathering information and communication applications in intelligent transportation and communication systems. Compact cylindrical arrays are particularly favored for their ability to achieve azimuth angle scanning. However, the substantial mutual coupling effect between the elements on curved surfaces and its implication for these arrays remain unclear, which is a key factor to consider when such arrays are used for multibeam applications. This study investigates the effect of mutual coupling in a dual-slant-polarized cylindrical array. The results showed that mutual coupling is predominantly observed among the closely located elements, and it is essential for achieving an ultra-wide bandwidth. The study also analyzes the impact of mutual coupling on the scan impedance and radiation characteristics for multibeam applications and reveals that these arrays exhibit robust multibeam capability, hence having great potential for use in sensing and communication applications.
Comprehensive Diagnosis of Localized Rolling Bearing Faults during Rotating Machine Start-Up via Vibration Envelope Analysis
Authors: Ruiz-Sarrio Jose E. , Antonino-Daviu Jose A. , Martis Claudia
Published: January 2024

The analysis of electrical machine faults during start-up, and variable speed and load conditions offers numerous advantages for fault detection and diagnosis. In this context, diagnosing localized bearing faults through vibration signals remains challenging, particularly in developing physically meaningful, simple, and resampling-free techniques to monitor fault characteristic components throughout machine start-up. This study introduces a straightforward method for qualitatively identifying the time-frequency evolutions of localized bearing faults during the start-up of an inverter-fed machine. The proposed technique utilizes the time-frequency representation of the envelope spectrum, effectively highlighting characteristic fault frequencies during transient operation. The method is tested in an open-source dataset including transient vibration signals. In addition, the work studies the method limitations induced by the mechanical transfer path, when the bearing surroundings are not directly accessible for vibration acquisition. The proposed methodology efficiently identifies incipient localized bearing faults during inverter-fed machine start-up when the fault signature is not highly attenuated.
Spectral-Kurtosis and Image-Embedding Approach for Target Classification in Micro-Doppler Signatures
Authors: Kim Ji-Hyeon , Kwon Soon-Young , Kim Hyoung-Nam
Published: January 2024

Micro-Doppler signature represents the micromotion state of a target, and it is used in target recognition and classification technology. The micro-Doppler frequency appears as a transition of the Doppler frequency due to the rotation and vibration of an object. Thus, tracking and classifying targets with high recognition accuracy is possible. However, it is difficult to distinguish the types of targets when subdividing targets with the same micromotion or classifying different targets with similar velocities. In this study, we address the problem of classification of three different targets with similar speeds and segmentation of the same type of targets. A novel signature extraction procedure is developed to automatically recognize drone, bird, and human targets by exploiting the different micro-Doppler signatures exhibited by each target. The developed algorithm is based on a novel adaptation of the spectral kurtosis technique of the radar echoes reflected by the three target types. Further, image-embedding layers are used to classify the spectral kurtosis of objects with the same micromotion. We apply a ResNet34 deep neural network to micro-Doppler images to analyze its performance in classifying objects performing micro-movements on the collected bistatic radar data. The results demonstrate that the proposed method accurately differentiates the three targets and effectively classifies multiple targets with the same micromotion.
Groundwater Exploration in Carbonate Reservoirs Using Borehole Investigations: A Case Study from South Dobrogea, Romania
Authors: Niculescu Bogdan Mihai , Bucur Maria Mădălina , Talmaciu Adrian
Published: January 2024

The Late Jurassic–Early Cretaceous (J3–K1) transboundary aquifer is the most important groundwater body in southern–southeastern Romania, shared with Bulgaria and hosted in karstic–fractured carbonates. We conducted an integrated evaluation of this aquifer by analyzing three 700 m deep groundwater exploration–exploitation boreholes, which intercepted it in the Cernavodă area (South Dobrogea region). The evaluation was based on geophysical wireline logging, drilling information, and borehole production tests. A K-means clustering of the logging data was performed for lithology typing, formation boundaries identification, and the delineation of probable producing intervals associated with secondary porosity development. Petrophysical interpretation was carried out via depth-constrained (zonal) inversion, using multimineral models, the estimated formation boundaries, and variable uncertainties for the main input logs. The optimal interpretation models were correlated with borehole testing results to gain insight into the hydrogeological properties of the aquifer complex. The fractured–vuggy interval with the highest water-producing potential was identified in the lower section of the J3-age Rasova Formation (639–700 m depth), comprising mainly undolomitized limestones. A southeast-to-northwest trend of increasing productivity of the boreholes, correlated with an increasing lateral dolomitization intensity within the Rasova Formation, suggests a highly heterogeneous character of the aquifer. The differences in productivity are due not only to local porosity variations but also to various degrees of pore space connectivity that are related to the amount of fracturing or karstification. The novel findings of this study have important practical implications for the optimal placement, design, and drilling program of future groundwater exploitation boreholes in the Cernavodă area and neighboring sectors.
A Deep Learning Approach to Optimize the Performance and Power Demand of Electric Scooters under the Effect of Operating and Structure Parameters
Authors: Hieu Le Trong , Lim Ock Taeck
Published: January 2024

The purpose of this study was to enhance electric scooter performance utilizing a novel method consisting of an artificial neural network (ANN) and genetic algorithm (GA) to predict power demand, battery voltage, and identify the optimal performance range. For training, validation, and testing, a dataset comprising 1000 data points for each parameter was extracted from a MATLAB-Simulink model. The ANN application was used to identify the battery voltage and power demand, reflecting the simulated results under varying key input parameters. Additionally, the GA was used to identify the optimal performance after the ANN had been trained. The results showed that the ES can achieve a speed of 28.2 km/h while using an optimal power of 553 W, at a wind velocity of 0 m/s, a slope ratio of 0%, and a wheel diameter of 0.37 m. The achieved results show that the ANN-GA method is appropriate for determining the operating and structural parameters for maximizing the performance of electric scooters. To support the simulated results, an experimental study was carried out with an actual road test along the Taehwa river.
Impact of Viscoelasticity on Sand-Carrying Ability of Viscous Slickwater and Its Sand-Carrying Threshold in Hydraulic Fractures
Authors: Han Xianzhu , Wu Junlin , Ji Yongjun , Liu Jinjun , Liu Yang , Xie Bobo , Chen Xianjiang , Yin Hui , Liang Tianbo
Published: January 2024

Viscous slickwater has a higher viscosity and better sand-carrying ability than conventional slickwater at the same concentration. At a concentration of 0.4 wt.%, the viscosity of the viscous slickwater is 4.7 times that of the conventional slickwater. It is generally believed that viscosity is one of the main influencing factors on the sand-carrying ability of the fluid. However, this study has shown that the good sand-carrying ability of the viscous slickwater is more attributed to its viscoelasticity. Through rheology and sand-carrying tests, it has been found that the viscoelastic properties vary when fluids have the same viscosity; this then leads to a significant difference in the settling rate of sand and the sand-carrying threshold of the fluid in a fracture at a certain flow rate. The routine method of characterizing the viscoelastic property of the slickwater was to observe the cross point of the elastic modulus (G′) and viscous modulus (G″) curves. The smaller the frequency of the cross point, the better the viscoelastic property of the fluid. However, it has been found in experiments that even when the cross point is the same, there is still a significant difference in the sand-carrying ability of fluids. Therefore, sand-carrying experiments are conducted under a similar cross point and different magnitudes of modulus, of which the results indicate that as the elastic modulus increases, the settling rate of sand decreases. The flow rate threshold occurring as sand settles obtained from laboratory experiments is compared with the field condition during hydraulic fracturing. From laboratory experiments, the threshold of inner-fracture flow rate that prevents the sand settling is found to be 8.02 m/min for 0.6 wt.% viscous slickwater with a sand ratio of 30%. In the field operation, the operation conditions meet the sand-carrying threshold obtained from laboratory experiments. Observations from the field test confirm the applicability of the threshold plot proposed according to laboratory measurements, which can provide guidance for optimizing the fracturing scheme in the field.
A Novel Trigonometric Entropy Measure Based on the Complex Proportional Assessment Technique for Pythagorean Fuzzy Sets
Authors: Kashyap Sahil , Paradowski Bartosz , Gandotra Neeraj , Saini Namita , Sałabun Wojciech
Published: January 2024

The extension of intuitionistic fuzzy sets (IFS) to Pythagorean fuzzy sets (PFS) is a significant advancement, addressing the inherent limitations of IFS. This study introduces a novel entropy measure specifically designed for Pythagorean fuzzy sets, establishing its axiomatic definition and presenting key properties. Decision making guided by entropy is advantageous, as it effectively mitigates ambiguity with increasing entropy values. Furthermore, a numerical example is provided to facilitate a comparative assessment of our newly introduced entropy measure in contrast to existing PFS entropy measures. The validation of our findings is achieved through the application of the COPRAS method, which determines decision outcomes based on a multitude of influencing factors. Notably, the determination of weights in this method is underpinned by the utilization of our innovative entropy measure.
A Minimum Entropy Production Approach to Optimization of Tubular Chemical Reactors with Nature-Inspired Design
Authors: Kizilova Natalya , Shankar Akash , Kjelstrup Signe
Published: January 2024

The problem of the shape optimization of tubular-type plug-flow chemical reactors equipped with a fluid flow-based cooling system is considered in this work. The hydraulic radius Rh(z) = 2A(z)/P(z) and an equivalent surface area-based radius Rs = P(z)/(2π) were computed from the cross-sectional area A(z) and perimeter P(z) measured along the nasal duct of Northern reindeer and used for shape optimization as nature-inspired design. The laminar flow in the cooling system was modeled using the Navier–Stokes equations for an incompressible liquid. In the central tube, a set of chemical reactions with temperature-dependent rates was considered. The temperature and flow velocity fields, pumping pressure, mass flow rate, and total heat flux Jth were obtained by numerical methods. Comparative analyses of the efficiency of different geometries were conducted on Pareto frontiers for hydraulic resistivity Zh, thermal resistivity Zth, thermal inlet length Lth, and entropy production Sirr as a sum of contributions from chemical reactions, thermal, and viscous dissipation. It was shown that the tube with Rs(z) as an interface between the reactor and cooler has the best Pareto efficiency using the (Zh,Zth,Lth) objective functions. Surprisingly, this design also exhibits the lowest Sirr and a more uniform distribution Sirr(z) (i.e., equipartition) among other designs. This geometry is suggested for densely packed tubular reactors.
Experimental Investigation on the Performance of the Scroll Expander under Various Driving Cycles
Authors: Yang Hailong , Xu Yonghong , Zhong Xiaohui , Zeng Jiajun , Yang Fubin
Published: January 2024

Energy storage is considered a crucial unit in utilizing renewable energy sources, and compressed air energy storage (CAES) provides a cost-effective solution. It offers the benefits of zero pollution, a long lifespan, low maintenance costs, and minimal environmental impact. In order to increase the possibilities of compressed air energy storage for vehicle power, the performance of the expander needs to be studied. First, a CAES unit test bench is established. Then, the volumetric flow rate, rotational speed, torque, and output power are examined. Additionally, the isentropic exhaust temperature, pressure, and gas consumption rate of the scroll expander are analyzed. Finally, analyzing the economic feasibility of the CAES unit entails running the unit under varied driving conditions. Results reveal that the pressure of the input expander is high, which will lead to greater torque, greater peak power, and a greater temperature drop, but the gas in the air tank will also run out quickly. The peak power of the scroll expander does not occur at the maximum volume flow rate, rotation speed, and torque. The basic investment of the CAES unit mainly depends on the peak output power.
Dynamic Modelling of Data Center Waste Heat Potential Integration in District Heating in Latvia
Authors: Pakere Ieva , Goncarovs Kirils , Grāvelsiņš Armands , Zirne Marita Agate
Published: January 2024

As demand for data centers (DC) has increased rapidly, so has their electricity consumption. Cooling DCs is essential to maintain optimal temperatures for the operation of servers and equipment. The consequence of the cooling process is that most of the electricity consumed in DCs, including cooling, is eventually dissipated as heat that is released into the atmosphere without any useful application. Recovering and reusing waste heat offers a sustainable solution to reduce primary energy consumption and minimize the environmental impact. Using waste heat from DCs to heat buildings can significantly improve the energy efficiency and environmental sustainability of DCs. Therefore, this research analyzes the existing potential of waste heat recovery from data centers in Latvia and proposes a system dynamic modelling approach for evaluation of the future impact of waste heat on the national heat supply. The overall waste heat generated by DCs in 2022 was 51.37 GWh at a temperature of 65 °C. By 2050, the total heat energy production potential from DCs will increase to 257 GWh, with 201 GWh being utilized.
Comparison of the Chemical and Microbial Composition and Aerobic Stability of High-Moisture Barley Grain Ensiled with Either Chemical or Viable Lactic Acid Bacteria Application
Authors: Jatkauskas Jonas , Vrotniakiene Vilma , Eisner Ivan , Witt Kristian Lybek , do Amaral Rafael Camargo
Published: January 2024

This experiment was aimed at comparing how a chemical additive or an inoculant would affect the dry matter (DM) losses, fermentation pattern, yeast and mold counts, and aerobic stability (AS) of the ensiled high-moisture barley grain (675 g kg−1 DM). Crimped barley grain was ensiled with or without chemical additive AIV Ässä Na and an inoculant SiloSolve FC, totaling three treatments (1 × 3 factorial scheme) for the fermentation periods lasting 7, 14, 28, 60, and 90 days. The application of a chemical additive showed higher pH levels, retained water-soluble carbohydrates (WSCs) better, lowered DM loss, and reduced concentrations of fermentation products. Barley grain treated with chemicals initially showed a marked reduction in yeast and fungal growth and a higher AS up to day 60 of storage but became less effective in later stages of storage, leading to decreased AS. Barley grain inoculated with homo- and heterofermentative strains had decreased silage pH; its WSC content was similar to control and had higher content of weak acids and 1,2 propanediol, reducing mold and yeast counts. With fermentation duration from 28 days and beyond (i.e., 90 days), the inoculant treatment achieved the longest AS and the lowest increase in pH and weight loss during the period of air exposure.
Burning Properties of Combined Glued Laminated Timber
Authors: Kytka Tomáš , Gašparík Miroslav , Novák David , Sahula Lukáš , Karami Elham , Das Sumanta
Published: January 2024

This study delved into the combustion properties of combined glulam bonded using polyurethane (PUR) and resorcinol-phenol-formaldehyde (RPF) adhesives. The experiment involved three distinct wood species, namely, spruce, alder, and beech, which were combined in homogeneous, non-homogeneous symmetrical, and non-homogeneous asymmetrical arrangements. These species were selected to represent a spectrum, namely, softwood (spruce), low-density hardwood (alder), and high-density hardwood (beech). The varying combinations of wood species illustrate potential compositions within structural elements, aiming to optimize mechanical bending resistance. Various parameters were measured during combustion, namely, the heat release rate (HRR), peak heat release rate (pHRR), mass loss rate (MLR), average rate of heat emission (ARHE), peak average rate of heat emission (MARHE), time to ignition (TTI), and effective heat of combustion (EHC). The findings indicate that incorporating beech wood into the composite glulam resulted in an increase in heat release, significantly altering the burning characteristics, which was particularly evident at the second peak. Conversely, the use of spruce wood exhibited the lowest heat release rate. Alder wood, when subjected to heat flux at the glued joint, displayed the highest heat emission, aligning with the results for EHC and MARHE. This observation suggests that wood species prone to early thermal decomposition emit more heat within a shorter duration. The time to ignition (TTI) was consistent, occurring between the first and second minute across all tested wood species and combinations. Notably, when subjected to heat flux, the glulam samples bonded with PUR adhesive experienced complete delamination of the initial two glued joints, whereas those bonded with RPF adhesive exhibited only partial delamination.
Effects of Cold Stress on the Hemolymph of the Pacific White Shrimp Penaeus vannamei
Authors: Zhu Jianqiang , Shi Wenjun , Zhao Ran , Gu Chen , Li Hui , Wang Libao , Wan Xihe
Published: January 2024

Temperature is an important factor in the physiological processes of aquatic organisms and can seriously affect several chemical and biological processes in their bodies, including respiratory metabolism, antioxidant capacity, immune capacity, and signal transduction. In this study, physiological, transcriptomic, and metabolomic analyses were used to investigate the response of Penaeus vannamei to cold stress. The results indicated that cold stress disrupted nucleotide metabolism and inhibited gluconeogenesis. However, shrimp exhibited response mechanisms in order to enhance cold tolerance, regulating changes in key genes and metabolites in amino acid and lipid metabolism to increase energy supply and protect cell membrane stability. In addition, the response included regulating Ca2+ pumps and ion channels to maintain intracellular ion homeostasis and osmotic balance. When the temperature dropped further, oxidative damage occurred due to overwhelming of the antioxidant defense system, and immune function was inhibited. This research provides some references regarding the molecular mechanisms involved in responding to cold stress and potential strategies to improve cold tolerance in P. vannamei; these are important references for studying the cold stress response of shrimp.
Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota
Authors: Li Qing , Wu Liling , Wang Guangnan , Zheng Fuping , Sun Jinyuan , Zhang Yuhang , Li Zexia , Li Lianghao , Sun Baoguo
Published: January 2024

The liver is critical in alcohol metabolism, and excessive consumption heightens the risk of hepatic damage, potentially escalating to hepatitis and cirrhosis. Jiuzao, a by-product of Baijiu production, contains a rich concentration of naturally active polysaccharides known for their antioxidative properties. This study investigated the influence of Laowuzeng Jiuzao polysaccharide (LJP) on the development of ethanol-induced alcoholic fatty liver. Zebrafish larvae served as the model organisms for examining the LJPs hepatic impact via liver phenotypic and biochemical assays. Additionally, this study evaluated the LJPs effects on gene expression associated with alcoholic fatty liver and the composition of the intestinal microbiota through transcriptomic and 16 S rRNA gene sequencing analyses, respectively. Our findings revealed that LJP markedly mitigated morphological liver damage and reduced oxidative stress and lipid peroxidation in larvae. Transcriptome data indicated that LJP ameliorated hepatic fat accumulation and liver injury by enhancing gene expression involved in alcohol and lipid metabolism. Furthermore, LJP modulated the development of alcoholic fatty liver by altering the prevalence of intestinal Actinobacteriota and Firmicutes, specifically augmenting Acinetobacter while diminishing Chryseobacterium levels. Ultimately, LJP mitigated alcohol-induced hepatic injury by modulating gene expression related to ethanol metabolism, lipid metabolism, and inflammation and by orchestrating alterations in the intestinal microbiota.
Influence of Nitrogen-Modified Atmosphere Storage on Lipid Oxidation of Peanuts: From a Lipidomic Perspective
Authors: Ma Xia , Li Wenhao , Zhang Huayang , Lu Peng , Chen Pengxiao , Chen Liang , Qu Chenling
Published: January 2024

The effect of nitrogen-modified atmosphere storage (NS) on peanut lipid oxidation was investigated in this paper. Non-targeted lipidomics was employed to detect the lipid metabolites in peanuts with the aim of exploring the mechanism of lipid oxidation in peanuts under different storage conditions. The results showed that compared with conventional storage (CS), NS significantly (p < 0.05) delayed the increase in acid value, carbonyl value, and 2-thiobarbituric acid value and the decrease in vitamin E content. However, the storage time has a much greater effect on lipid oxidation than the oxygen level in the storage environment. Lipidomics analysis revealed that there were significant differences in metabolite changes between CS and NS. NS reduced the decline of most glycerophospholipids by regulating lipid metabolism in peanuts. NS maintained higher levels of Diacylglycerol (DAG), sulfoquinovosyl diacylglycerol (SQDG), lysophophatidylcholine (LPC), lysophosphatidylethanolamine (LPE) and phosphatidylinositol (PI) compared to CS. This work provided a basis for the application of NS technology to peanut storage.
Grape Pomace Rich-Phenolics and Anthocyanins Extract: Production by Pressurized Liquid Extraction in Intermittent Process and Encapsulation by Spray-Drying
Authors: Silva Jessica Thaís do Prado , Borges Millene Henrique , de Souza Carlos Antonio Cardoso , Fávaro-Trindade Carmen Sílvia , Sobral Paulo José do Amaral , de Oliveira Alessandra Lopes , Martelli-Tosi Milena
Published: January 2024

A considerable number of grape pomaces are generated annually. It represents a rich source of bioactive compounds, such as phenolic compounds and anthocyanins. Pressurized liquid extraction (PLE) has emerged as a green technology for recovering bioactive compounds from vegetal matrixes. In our study, PLE parameters (temperature, number of cycles, and rinse volume) have been studied to produce grape pomace extracts with high bioactive content using an experimental design. The experimental data obtained were adjusted to linear and quadratic models. The first-order model was better in predicting anthocyanins contents (TA, R2 = 0.94), whereas the second-order model was predictive for total phenolic compounds (TPC, R2 = 0.96). The main process parameter for the recovery of bioactive compounds was temperature, and the results showed opposing behaviors concerning TPC and TA, as it is difficult to optimize conditions for both. The extract containing the higher concentration of TPC (97.4 ± 1.1 mg GAE/g, d.b.) was encapsulated by spray-drying using maltodextrin as wall material. Particles presented with a spherical shape (~7.73 ± 0.95 μm) with a recovery yield of 79%. The results demonstrated that extraction followed by encapsulation of grape pomace extract is a good strategy to simplify future applications, whether for food, cosmetics or pharmaceutical fields.
Physicochemical Features and Volatile Organic Compounds of Horse Loin Subjected to Sous-Vide Cooking
Authors: Sujiwo Joko , Lee Sangrok , Kim Dongwook , Lee Hee-Jeong , Oh Soomin , Jung Yousung , Jang Aera
Published: January 2024

The purpose of this study was to evaluate the effect of temperature and time of sous-vide cooking method on the characteristics of Thoroughbred horse loin. Sliced portions (200 ± 50 g) were cooked by boiling (control) and sous-vide (65 and 70 °C for 12, 18, and 24 h). The samples were analyzed for proximate composition, pH, color, texture, microstructure, sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), microbiology, volatile organic compounds (VOCs), nucleotide content, and fatty acids composition. The color analysis showed decreased redness at elevated temperatures. Improved tenderness, demonstrated by reduced shear force values (36.36 N at 65 °C for 24 h and 35.70 N at 70 °C for 24 h). The micrographs indicated dense fiber arrangements at 70 °C. The SDS-PAGE revealed muscle protein degradation with extended sous-vide cooking. The VOC analysis identified specific compounds, potentially distinctive markers for sous-vide cooking of horse meat including 1-octen-3-ol, decanal, n-caproic acid vinyl ester, cyclotetrasiloxane, octamethyl, and 3,3-dimethyl-1,2-epoxybutane. This study highlights the cooking time’s primary role in sous vide-cooked horse meat tenderness and proposes specific VOCs as potential markers. Further research should explore the exclusivity of these VOCs to sous-vide cooking.
Potential of Cricket (Acheta domesticus) Flour as a Lean Meat Replacer in the Development of Beef Patties
Authors: Pasqualin Cavalheiro Carlos , Ruiz-Capillas Claudia , Herrero Ana M. , Pintado Tatiana , Avelar de Sousa Camila Cristina , Sant’Ana Falcão Leite Juliana , Costa Alves da Silva Maurício
Published: January 2024

This study examined the incorporation of cricket (Acheta domesticus) flour (CF) (0, control; 5.0%, CF5.0; 7.5%, CF7.5; and 10.0%, CF10.0) as a lean meat replacer in beef patties and its impact on composition, microbiological, sensory, and technological properties, as well as its influence on the cooking process. The inclusion of CF led to beef patties with significantly higher protein levels than the control group. Additionally, an elevation in total viable (TVC) and lactic acid bacteria (LAB) counts was observed. However, Enterobacteriaceae counts remained at safe levels. CF5.0 demonstrated similar sensory scores and purchase intention to the control treatment. CF7.5 and CF10.0 showed comparable sensory scores to the control except for texture attributes. The inclusion of CF significantly reduced cooking loss and diameter reduction values. Beef patties with CF were notably firmer and had a browner color than the control. In general, the cooking process impacted the technological properties similarly in both the control and beef patties with CF. In all cooked samples, no significant differences in pH, redness (a*), or texture were observed. This study demonstrated that incorporating up to 5.0% CF into beef patties is optimal in terms of composition, technological, sensorial, and cooking properties.
Spontaneous Coronary Artery Dissection as a Cause of Acute Myocardial Infarction in COVID-19 Patients: A Case Report and Review of the Literature
Authors: Papageorgiou Angeliki , Moulias Athanasios , Papageorgiou Athanasios , Karampitsakos Theodoros , Apostolos Anastasios , Tsigkas Grigorios , Davlouros Periklis
Published: January 2024

Patients with COVID-19 often experience significant cardiovascular complications, including heart failure, myocarditis, and acute coronary syndrome. We present the case of a male patient with severe COVID-19 pneumonia, complicated with inferior ST-segment elevation myocardial infarction (STEMI), which was attributed to spontaneous coronary artery dissection (SCAD). We also make a review of the literature on case reports of patients with COVID-19 and acute myocardial infarction due to SCAD. Through these clinical cases, a potential correlation between SCAD and COVID-19 infection is implied. Endothelial dysfunction, thrombotic complications, and disturbance of the vascular tone are established COVID-19 sequelae, triggered either by direct viral injury or mediated by the cytokines’ storm. These abnormalities in the coronary vasculature and the vasa vasorum could result in SCAD. Moreover, disturbances of the vascular tone can cause coronary vasospasm, a reported precipitant of SCAD. Thus, SCAD should be considered in COVID-19 patients with acute coronary syndrome (ACS), and in the case of STEMI, an early angiographic evaluation, if feasible, should be performed rather than thrombolysis to avoid potential adverse events of the latter in the setting of SCAD.
An Italian Survey and Focus Groups on Fibromyalgia Impairment: Impact on Work and Possible Reasonable Accommodations
Authors: Tenti Michael , Raffaeli William , Paroli Mery , Gamberi Gabriele , Vincis Riccardo , Suzzi Barbara , Fagnani Corrado , Camoni Laura , Toccaceli Virgilia
Published: January 2024

Fibromyalgia symptoms affect the sufferers’ working life; however, through reasonable accommodations in workplaces, they can continue to work satisfactorily. There are no Italian studies on factors that facilitate or hinder fibromyalgia-affected people’s working life. Our objective was to explore, in a pre-pandemic setting, the quality of working life of fibromyalgia sufferers and reasonable accommodations to improve it. Quantitative and qualitative methods were applied; a survey-questionnaire, participatory-developed, was online-administered to a sample of self-reported FM sufferers (N = 1176). Then, two Focus Groups (FGs), involving 15 fibromyalgia-affected women, were held. Data were analyzed by a thematic analysis approach. Among survey-respondents, 20% were unemployed and only 14% went to work gladly. Variability of pain (84%) and fatigue (90%) were the most perceived reasons for difficulties at work. Negative relationships at work were reported by most participants. The FGs’ discussions addressed different strategies for overcoming the main obstacle of “not being believed by colleagues and employers” and reasonable accommodations. However, a negative hopeless attitude towards the solution of problems at work was also apparent. Different critical issues in the workplace emerged from the survey and the FGs. Coordinated actions, according to a transdisciplinary approach, are needed to manage fibromyalgia-induced difficulties in the workplace.
Sudden-Onset Acute Obsessive-Compulsive Disorder Associated with Streptococcus and Brain MRI Hyperintensity in a Young Adult
Authors: Jory Joan , Handelman Kenneth
Published: January 2024

Background: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal (strep) infections (PANDAS) are a recognized medical entity among children. But evidence for strep-mediated sudden-onset obsessive–compulsive disorder (OCD) in young adults is very limited. Delayed strep assessment and treatment may negatively impact clinical outcomes. Methods: We describe a young adult with acute sudden-onset OCD (age 24), treated unsuccessfully with medication and therapy for 3 years. At age 27, antistreptolysin-O (ASO) was tested, based on extensive pediatric history of strep infections. Antibiotic treatment was initiated. Results: Magnetic resonance imaging (MRI) identified a new temporal lobe hyperintensity at OCD onset (age 24), which persisted at ages 25 and 30. ASO titers were elevated from age 27 through 29. Following Amoxicillin treatment, ASO initially increased. Subsequent Amoxicillin + Clavulin treatment produced improved OCD symptoms and treatment response, with no adverse effects. Conclusion: These results strongly suggest an association among strep infection, neuro-inflammation and sudden-onset OCD in this young adult whose response to medication and therapy was successful only after high-dose antibiotic intervention. Greater OCD remission potential may be possible with earlier identification and antibiotic treatment than 3 years post OCD onset. These findings add to the limited literature on strep as an etiology of the sudden-onset of OCD in young adults. They also lend urgency to increased frontline awareness for early strep and ASO assessment in sudden-onset acute OCD among young adults.
Exploring MicroRNAs Associated with Pomegranate Pistil Development: An Identification and Analysis Study
Authors: Zhao Yujie , Huang Jingyi , Li Ming , Ren Hongfang , Jiao Jian , Wan Ran , Liu Yu , Wang Miaomiao , Shi Jiangli , Zhang Kunxi , Hao Pengbo , Song Shangwei , Bai Tuanhui , Zheng Xianbo
Published: January 2024

The interaction between miRNAs (microRNAs) and target genes plays an important role in plant pistil development. MiRNAs related to pistils were explored in pomegranate. The differentially expressed miRNAs were screened at different developmental stages of pomegranate pistils, and their target differentially expressed mRNAs were further identified to clarify the regulatory effect of miRNAs on pistil development. In our study, 61 conserved miRNAs were identified in 30 families, including miR395, miR394, miR393, miR161, miR162, and miR168. Among them, miR156, miR157, miR159, miR160, miR164, miR165, miR166, miR167, miR169, and miR172 were involved in the development of flower organs. Eight miRNAs were randomly selected and verified for qRT-PCR analysis. The result analysis indicated that miR160, miR164, and miR172 might be positive factors in the regulation of pomegranate pistil development. MiR156 and miR166 might be involved in regulation of pomegranate pistil development as negative factors.
Environmental Preferences and Concerns of Recreational Trail Runners
Authors: Rosenkrantz Leah , Schuurman Nadine , Lear Scott A.
Published: January 2024

Trail running is a fast-growing sport, linked to improvements in both physical and psychological well-being. Despite its popularity, the preferences of trail runners are not well known. The objective of this study was to examine the environmental preferences and concerns of trail runners with respect to age and gender. We conducted a cross-sectional survey of recreational trail runners. A total of 548 people responded, of which 50.1% of respondents were women and 44.2% were men. The sample was distributed relatively evenly across age groups, up to 54 years; respondents over 55 represented only 9.4% of the sample. Comparisons of runner characteristics by gender indicated significant differences (p < 0.05) according to age, distance run per week, and number of days run per week. Certain runner preferences also differed significantly by gender, including importance of running around others, the type of trail races they seek, and whether or not they like to seek “vert” or elevation in their runs. Major concerns for both genders while running included lack of cell reception (Men: 33.8%; Women: 50.8%) and getting lost (Men: 26.8%; Women: 35.5%). Comparisons of the results of this study help to strengthen our understanding of trail runners’ environmental preferences and concerns and can be used to guide future design and maintenance of trail environments to encourage greater participation in the sport.
Knowledge, Attitudes, and Subjective Norms Associated with COVID-19 Vaccination among Pregnant Women in Kenya: An Online Cross-Sectional Pilot Study Using WhatsApp
Authors: Ayieko Sylvia , Jaoko Walter , Opiyo Rose Okoyo , Orang’o Elkanah Omenge , Messiah Sarah E. , Baker Kimberly , Markham Christine
Published: January 2024

COVID-19 vaccination during pregnancy has been recommended, but the perceptions related to uptake remain unexplored. This pilot study aimed to explore how perceptions influence COVID-19 vaccine uptake among a sample of 115 pregnant women in Kenya, recruited via WhatsApp. Data were collected using an adapted online questionnaire between May and October 2022. Logistic analyses assessed the relationship between COVID-19 vaccination uptake and the Theory of Reasoned Action (TRA) constructs: attitudes and subjective norms. COVID-19 vaccination coverage was 73%, with vaccine hesitancy estimated at 41.4% among the unvaccinated group. Most participants had completed college education and had good knowledge of COVID-19 vaccines. There was no significant effect of enrollment in WhatsApp pregnancy groups on attitudes toward COVID-19 vaccination. Pregnant women were concerned about vaccine effectiveness (31.1%), and almost one-half (47.3%) were discouraged from receiving COVID-19 vaccines. Positive attitudes towards vaccination were associated with COVID-19 vaccination (aOR 2.81; 95% CI 1.12–7.04; p = 0.027), but no significant relationship was found between COVID-19 vaccination and strong subjective norms (influences to get COVID-19 vaccines). Our findings suggest that strategies to improve vaccination should consider targeting attitudes and proximal social networks (friends/family) to facilitate vaccination decision-making. WhatsApp can be used for research distribution and enhance the dissemination of accurate information.
The Role of Pro-Inflammatory Cytokines in the Pathogenesis of Cardiovascular Disease
Authors: Zhang Hannah , Dhalla Naranjan S.
Published: January 2024

With cardiovascular disease (CVD) being a primary source of global morbidity and mortality, it is crucial that we understand the molecular pathophysiological mechanisms at play. Recently, numerous pro-inflammatory cytokines have been linked to several different CVDs, which are now often considered an adversely pro-inflammatory state. These cytokines most notably include interleukin-6 (IL-6),tumor necrosis factor (TNF)α, and the interleukin-1 (IL-1) family, amongst others. Not only does inflammation have intricate and complex interactions with pathophysiological processes such as oxidative stress and calcium mishandling, but it also plays a role in the balance between tissue repair and destruction. In this regard, pre-clinical and clinical evidence has clearly demonstrated the involvement and dynamic nature of pro-inflammatory cytokines in many heart conditions; however, the clinical utility of the findings so far remains unclear. Whether these cytokines can serve as markers or risk predictors of disease states or act as potential therapeutic targets, further extensive research is needed to fully understand the complex network of interactions that these molecules encompass in the context of heart disease. This review will highlight the significant advances in our understanding of the contributions of pro-inflammatory cytokines in CVDs, including ischemic heart disease (atherosclerosis, thrombosis, acute myocardial infarction, and ischemia-reperfusion injury), cardiac remodeling (hypertension, cardiac hypertrophy, cardiac fibrosis, cardiac apoptosis, and heart failure), different cardiomyopathies as well as ventricular arrhythmias and atrial fibrillation. In addition, this article is focused on discussing the shortcomings in both pathological and therapeutic aspects of pro-inflammatory cytokines in CVD that still need to be addressed by future studies.
Transcription Factors in the Pathogenesis of Lupus Nephritis and Their Targeted Therapy
Authors: Shao Kasey M. , Shao Wen-Hai
Published: January 2024

Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease, characterized by breakdown of immunotolerance to self-antigens. Renal involvement, known as lupus nephritis (LN), is one of the leading causes of morbidity and a significant contributor to mortality in SLE. Despite current pathophysiological advances, further studies are needed to fully understand complex mechanisms underlying the development and progression of LN. Transcription factors (TFs) are proteins that regulate the expression of genes and play a crucial role in the development and progression of LN. The mechanisms of TF promoting or inhibiting gene expression are complex, and studies have just begun to reveal the pathological roles of TFs in LN. Understanding TFs in the pathogenesis of LN can provide valuable insights into this disease’s mechanisms and potentially lead to the development of targeted therapies for its management. This review will focus on recent findings on TFs in the pathogenesis of LN and newly developed TF-targeted therapy in renal inflammation.
Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis
Authors: Rezzani Rita , Gianò Marzia , Pinto Daniela , Rinaldi Fabio , van Noorden Cornelis J. F. , Favero Gaia
Published: January 2024

Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology is not well understood. It is known that genetic and nongenetic factors determine alterations in several organs, such as the liver, in individuals with this disorder. The aims of the present study were to analyze morphological and biological alterations in the liver of an autistic mouse model, BTBR T + Itpr3tf/J (BTBR) mice, and to identify therapeutic strategies for alleviating hepatic impairments using melatonin administration. We studied hepatic cytoarchitecture, oxidative stress, inflammation and ferroptosis in BTBR mice and used C57BL6/J mice as healthy control subjects. The mice were divided into four groups and then treated and not treated with melatonin, respectively. BTBR mice showed (a) a retarded development of livers and (b) iron accumulation and elevated oxidative stress and inflammation. We demonstrated that the expression of ferroptosis markers, the transcription factor nuclear factor erythroid-related factor 2 (NFR2), was upregulated, and the Kelch-like ECH-associated protein 1 (KEAP1) was downregulated in BTBR mice. Then, we evaluated the effects of melatonin on the hepatic alterations of BTBR mice; melatonin has a positive effect on liver cytoarchitecture and metabolic functions.