bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Approach on the Advancement in Polymer Phase Change Material in Solar Energy
Authors: Jegan G. , Ramani P. , Nagalakshmi T. J. , Chitra S. , Lawrence T. Samraj
Published: January 2022

A wide interest has been shown in the application of solar energy in recent times. This motivated the researchers to make a development in the approach of solar energy, but there are different technologies like MPPT, CPG, and grid mode that have been used to maintain a constant temperature. Among these, phase change material has been used to regulate the temperature in the system. Solar energy is becoming an essential approach for increasing the efficiency of thermal energy conversion and utilizing polymeric step change composites, which have attracted extremely large interest in recent years due to their advantages of high energy density and powerful energy output stability. A plethora of reviews and reports have been published to compile the diverse range of PCMs made available for various applications. PCMs are created by improving thermophysical thermodynamic stability, latent heat, and heat capacity. Furthermore, the possible applications of polymer phase PCMs in a variety of fields, such as energy storage devices, thermal corrective action, and temperature-controlled drug carriers, are detailed. In this paper, a novel approach on the advancement of nanoconfined phase change material is defined along with the application of the solar energy system.
Digital Twins by Physical Education Teaching Practice in Visual Sensing Training System
Authors: Liu Xinran , Jiang Ji
Published: January 2022

The paper expects to improve the efficiency and intelligence of somatosensory recognition technology in the application of physical education teaching practice. Firstly, the combination of induction recognition technology and the Internet is used. Secondly, through the Kinect sensor, bone data are acquired. Finally, the hidden Markov model (HMM) is used to simulate the experimental data. On the simulation results, a gait recognition algorithm is proposed. The gait recognition algorithm is used to identify the motion behaviour, and the results are displayed in the Web (World Wide Web) end built by the cloud server. Meantime, in view of the existing problems in the practice of physical education, combined with the establishment and operation of the Digital Twins (DTs) system, the camera source recognition architecture is carried out since the twin network and the two network branches share weights. This paper analyses these problems since the application of somatosensory recognition technology and puts forward the improvement methods. For the single problem of equipment in physical education, this paper puts forward the monitoring and identification function of the cloud server. It is to transmit data through Hypertext Transfer Protocol (HTTP) and locate and collect data through a monitoring terminal. For the lack of comprehensiveness and balance of sports plans, this paper proposes a scientific training plan and process customization based on Body Mass Index (BMI), analyses real‐time data in the cloud, and makes scientific customization plans according to different students’ physical conditions. Moreover, 25 participants are invited to carry out the exercise detection and analysis experiment, and the joint monitoring of their daily movements is tested. This process has completed the design of a feasible and accurate platform for information collection and processing, which is convenient for managers and educators to comprehensively and scientifically master and manage the physical level and training of college students. The proposed method improves the recognition rate of the camera source to some extent and has important exploration significance in the field of action recognition.
A Pilot Study of Gene Expression Analysis in Peripheral Blood Mononuclear Cells in Response to a Hypocaloric Mediterranean Diet
Authors: de Luis Daniel , Primo David , Izaola Olatz , Aller Rocío
Published: January 2022

Background. Few studies have examined gene expression in peripheral blood mononuclear cells (PBMCs) after a dietary intervention. Objective. Our study is aimed at evaluating in a pilot study the peripheral blood gene expression in obese patients after weight loss secondary to a hypocaloric Mediterranean diet. Design. A sample of 11 obese subjects without metabolic syndrome was enrolled. Biochemical, anthropometric parameters and microarray analysis were performed at baseline and after 6 months of dietary intervention. Results. The mean age was

43.1
±
6.3

years, and the mean body mass index (BMI) was

38.6
±
8.1

 kg/m2. All the next improvements were statistically significant: body weight

−
7.4
±
1.9

 kg, BMI -

2.5
±
0.2

 kg, fat mass

−
5.7
±
1.2

 kg, waist circumference

−
5.8
±
1.2

 cm, triglycerides

−
17.4
±
6.5

 mg/dl, C-reactive protein

−
3.1
±
1.5

 mg/dL, insulin

−
2.1
±
1.0

 mUI/L, and HOMA-IR

−
0.7
±
0.2

 units. We identified 634 differentially expressed genes: 262 genes with relative higher expression levels and 372 with lower expression levels. Cluster analysis showed 35 genes in nutritional disease and 17 genes in endocrine system. The most relevant gene was thyroid peroxidase (TPO), and this gene was overexpressed, and the next genes carbonic anhydrase VI (CA6), caveolin protein 1 (CAV1) and solute carrier family type 12 (SLLC12A3), soluble carrier family type 12 (SLLC12A3), beta 3 receptor (ADRB3), and glutamate receptor ionotropic N methyl D aspartate 2 A (GRIN2A) were all underexpressed. Conclusion. In PBMC from obese patients after a diet with a Mediterranean pattern, the expression of 634 genes, of the endocrine system and of nutritional disease, is modified.
Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer
Authors: Mortazavi Deniz , Sohrabi Behnoush , Mosallaei Meysam , Nariman-Saleh-Fam Ziba , Bastami Milad , Mansoori Yaser , Daraei Abdolreza , Zununi Vahed Sepideh , Navid Shadan , Saadatian Zahra , Jamialahmadi Tannaz , Teng Yong , Sahebkar Amirhossein
Published: January 2022

Cancer is a leading cause of death and disability worldwide. Epigenetic deregulation is one of the most critical mechanisms in carcinogenesis and can be classified into effects on DNA methylation and histone modification. MicroRNAs are small noncoding RNAs involved in fine-tuning their target genes after transcription. Various microRNAs control the expression of histone modifiers and are involved in a variety of cancers. Therefore, overexpression or downregulation of microRNAs can alter cell fate and cause malignancies. In this review, we discuss the role of microRNAs in regulating the histone modification machinery in various cancers, with a focus on the histone-modifying enzymes such as acetylases, deacetylases, methyltransferases, demethylases, kinases, phosphatases, desumoylases, ubiquitinases, and deubiquitinases. Understanding of microRNA-related aberrations underlying histone modifiers in pathogenesis of different cancers can help identify novel therapeutic targets or early detection approaches that allow better management of patients or monitoring of treatment response.
Extraction, Purification, Optimization, and Application of Galactomannan-Based Edible Coating Formulations for Guava Using Response Surface Methodology
Authors: Ainee Ammara , Hussain Sarfraz , Nadeem Muhammad , Al-Hilphy Asaad R. , Siddeeg Azhari
Published: January 2022

Galactomannan from fenugreek and guar seeds were extracted, purified, and used in edible coatings, optimized via response surface methodology. The results showed that the emulsifying capacity and stability of fenugreek galactomannan (FG) and guar galactomannan (GG) increased with increase in the concentration of galactomannan up to 0.5–1%. The average optimized values of FG and GG in edible coatings were predicted to be 1.71% and 2.11% for weight loss, 0.72% and 2.14% for firmness, 1.02% and 1.44% for TSS, 0.83% and 1.36% for pH, 1.03% and 1.44% for acidity, respectively. Significant decrease in weight loss and maximum retention of firmness was observed in coated guava. The TSS increased up to a certain storage period in all treatments and decreased as the storage period progressed, whereas pH exhibited an increasing trend while a significant decrease in acidity was observed. The findings revealed that the shelf life of guava could considerably be improved by incorporating 1.24% galactomannan from GG and 1.01% from FG in the edible coating.
An Immunity Passport Scheme Based on the Dual-Blockchain Architecture for International Travel
Authors: Gao Hancheng , Ji Haoyu , Huang Haiping , Xiao Fu , Jian Luo
Published: January 2022

The implementation of immunity passport has been hampered by the controversies over vaccines in various countries, the privacy of vaccinators, and the forgery of passports. While some existing schemes have been devoted to accelerating this effort, the problems above are not well solved in existing schemes. In this paper, we present an immunity passport scheme based on the dual-blockchain architecture, which frees people from the cumbersome epidemic prevention process while traveling abroad. Specially, the dual-blockchain architecture is established to fit with the scenarios of immunity passport. Searchable encryption and anonymous authentication are utilized to ensure users’ privacy. In addition, the performance and security evaluations show that our scheme achieves the proposed security goals and surpasses other authentication schemes in communicational and computational overheads.
Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice
Authors: Li Fei , Han Dan , Wang Bo , Zhang Wentao , Zhao Yan , Xu Jing , Meng Liesu , Mou Kuanhou , Lu Shemin , Zhu Wenhua , Zhou Yan
Published: January 2022

Itch is one of the major clinical manifestations of psoriasis, which is closely related with neurogenic inflammation and difficult to control. Colquhounia Root (CR) is a Chinese herb exhibiting broad bioactivities on anti-inflammation. This study was designed to explore the antipsoriatic and anti-itch potential of CR and its underlying mechanisms. Mice in a model of imiquimod-induced psoriasiform dermatitis were treated topically with CR for 7 days, and the severity of skin lesions and itch was significantly ameliorated. CR reduced the inflammatory cell infiltration, as well as mast cells in skins. Particularly, the expression of inflammatory cytokines and chemokine including Il17a, Il22, and Ccl20 and itch-related molecules such as SP, CGRP, and NGF in lesions were decreased in diseased mice upon application with CR. The normal human epidermal keratinocytes were stimulated with the M5 cytokine cocktail, the mixture of IL-17A, IL-22, Oncostatin M, IL-1α, and TNF-α, and cell viability and mRNA expression levels of inflammatory factors and itch-related molecules were measured after being treated with CR. We found that CR inhibited both cell hyperproliferation and overexpression of inflammatory cytokines and itch-related molecules in vitro. Altogether, we conclude that CR relieves psoriatic lesions and itch via controlling immunological and neurogenic inflammation.
Design and Implementation of Football Player Training Management System Based on Intelligent Image
Authors: Sun Yang , Hu Changjun
Published: January 2022

This article is aimed at studying the design and implementation of a football player training management system based on smart images. Based on the analysis of the importance of informatization for scientific football training, system performance requirements and intelligent image detection technology, the football player training management is designed. The overall architecture of the system, and the detailed design of each functional module of the system. It mainly includes football player information management module, football player training plan viewing module, training goal formulation module and training information feedback module. The realization of the training management system relies on intelligent image technology to detect and track athletes. Finally, the performance of the system was tested. The test results show that the expected response time of each module of the system when different numbers of users are accessed is within 3 seconds. The longest actual time is 2.64 s, and the actual shortest time is 1.18 s. It can be seen that the response time of the system meets the demand. At the same time, the system throughput rate meets the requirements of this article, and the user pass rate is also above 95%, indicating that the performance of the football player training management system designed in this article is better.
Refining Vegetable Oils: Chemical and Physical Refining
Authors: Gharby Said
Published: January 2022

This review presents recent technologies involved in vegetable oil refining as well as quality attributes of crude oils obtained by mechanical and solvent extraction. Usually, apart from virgin oils, crude oils cannot be consumed directly or incorporated into various food applications without technological treatments (refining). Indeed, crude oils like soybean, rapeseed, palm, corn, and sunflower oils must be purified or refined before consumption. The objective of such treatments (chemical and physical refining) is to get a better quality, a more acceptable aspect (limpidity), a lighter odor and color, longer stability, and good safety through the elimination of pollutants while minimizing oil loss during processing. However, the problem is that refining removes some essential nutrients and often generates other undesirable compounds such as 3-MCPD-esters and trans-fatty acids. These compounds directly influence the safety level of refined oil. Advantages and drawbacks of both chemical and physical refining were discussed in the light of recent literature. Physical refining has several advantages over chemical one.
Elaborate the Mechanism of Ancient Classic Prescriptions (Erzhi Formula) in Reversing GIOP by Network Pharmacology Coupled with Zebrafish Verification
Authors: Cai Zhihui , Wang Huajun , Jiang Jun , Xiao Shichang , Xiao Jianpeng , He Jinjin , Zhao Zihan , Yin Jiangning
Published: January 2022

Osteoporosis is a degenerative disease that endangers human health. At present, chemical drugs used for osteoporosis have serious side effects. Therefore, it is valuable to search herbs with high safety and good curative effect in antiosteoporosis. Erzhi formula (EZF), an ancient classic compound, has been reported to have a beneficial effect in antiosteoporosis, but its mechanism is unclear. In this paper, the active compounds of EZF were found in Systems Pharmacology Database, and gene targets related to osteoporosis were obtained in GeneCards. The GO functional and KEGG pathway enrichment analysis were performed by Metascape. The network of “components-targets-signal pathway” was constructed by Cytoscape. Next, molecular docking between the active components and hub genes related to the PI3K-Akt signaling pathway was conducted by Autodock. In the verification experiment, the zebrafish induced by prednisolone (PNSL) was used to reproduce glucocorticoid-induced osteoporosis (GIOP) model, and then the reversal effects of EZF were systematically evaluated according to the behavior, skull staining area, bone mineralization area (BMA), average optical density (AOD), and cumulative optical density (COD). Finally, it was shown that 24 components in EZF could regulate 39 common gene targets to exert antiosteoporosis effect. Besides, the main regulatory mechanisms of EZF were 4 signaling pathways: PI3K-Akt, JAK-STAT, AGE-RAGE, and cancer pathway. In PI3K-Akt signaling pathway, wedelolactone, dimethyl wedelolactone, specnuezhenide, ursolic acid, acacetin, beta-sitosterol, apigenin, and kaempferol can bind tightly with EGF, IL-2, and IL-4 genes. Compared with the model group, the moving distance, swimming speed, and cumulative swimming time of zebrafish in EZF group were significantly increased (P<0.05). Meanwhile, the BMA and COD of zebrafish were significantly improved after the intervention of EZF (P<0.05). In summary, the 24 components of EZF exert their antiosteoporosis effects by regulating 39 related gene targets, among which the PI3K signaling pathway is crucial. EZF can promote bone formation and reversed GIOP through “multicomponent/multitarget/multipathway” and the medium dose of EZF may be the most suitable concentration for the treatment of GIOP in zebrafish model.
A Comparative Study of Gene Expression in Menstrual Blood‐Derived Stromal Cells between Endometriosis and Healthy Women
Authors: Sahraei Seyedeh Saeideh , Davoodi Asl Faezeh , Kalhor Naser , Sheykhhasan Mohsen , Fazaeli Hoda , Moud Sanaz Soleymani , Sheikholeslami Azar
Published: January 2022

Background. Research into the pathogenesis of endometriosis would substantially promote its effective treatment and early diagnosis. Currently, accumulating evidence has shed light on the importance of endometrial stem cells within the menstrual blood which are involved in the establishment and progression of endometriotic lesions in a retrograde manner. Objectives. We aimed to identify the differences in some genes’ expression between menstrual blood‐derived mesenchymal stem cells (MenSCs) isolated from endometriosis patients (E‐MenSCs) and MenSCs from healthy women (NE‐MenSCs). Methods. Menstrual blood samples (2‐3 mL) from healthy and endometriosis women in the age range of 22–35 years were collected. Isolated MenSCs by the Ficoll‐Paque density‐gradient centrifugation method were characterized by flow cytometry. MenSCs were evaluated for key related endometriosis genes by real‐time‐PCR. Results. E‐MenSCs were morphologically different from NE‐MenSCs and showed, respectively, higher and lower expression of CD10 and CD9. Furthermore, E‐MenSCs had higher expression of Cyclin D1 (a cell cycle‐related gene) and MMP‐2 and MMP‐9 (migration‐ and invasion‐related genes) genes compared with NE‐MenSCs. Despite higher cell proliferation in E‐MenSCs, the BAX/BCL‐2 ratio was significantly lower in E‐MenSCs compared to NE‐MenSCs. Also, the level of inflammatory genes such as IL1β, IL6, IL8, and NF‐κB and stemness genes including SOX2 and SALL4 was increased in E‐MenSCs compared with NE‐MenSCs. Further, VEGF, as a potent angiogenic factor, showed a significant increase in E‐MenSCs rather than NE‐MenSCs. However, NE‐MenSCs showed increased ER‐α and β‐catenin when compared with E‐MenSCs. Conclusion. Here, we showed that there are gene expression differences between E‐MenSCs and NE‐MenSCs. These findings propose that MenSCs could play key role in the pathogenesis of endometriosis and further support the menstrual blood retrograde theory of endometriosis formation. This could be of great importance in exploiting promising therapeutic targets and new biomarkers for endometriosis treatment and prognosis.
The Effectiveness of Transcranial Magnetic Stimulation (TMS) Paradigms as Treatment Options for Recovery of Language Deficits in Chronic Poststroke Aphasia
Authors: Georgiou Anastasios M. , Kambanaros Maria
Published: January 2022

Background. In an effort to boost aphasia recovery, modern rehabilitation, in addition to speech and language therapy (SALT), is increasingly incorporating noninvasive methods of brain stimulation. The present study is aimed at investigating the effectiveness of two paradigms of neuronavigated repetitive transcranial magnetic stimulation (rTMS): (i) 1 Hz rTMS and (ii) continuous theta burst stimulation (cTBS) each as a standalone treatment for chronic aphasia poststroke. Methods. A single subject experimental design (SSED) trial was carried out in which six people with aphasia (PWA) were recruited, following a single left hemispheric stroke more than six months prior to the study. Three individuals were treated with 1 Hz rTMS, and the remaining three were treated with cTBS. In all cases, TMS was applied over the right pars triangularis (pTr). Language assessment, with standardized and functional measures, and cognitive evaluations were carried out at four time points: twice prior to treatment (baseline), one day immediately posttreatment, and at follow-up two months after treatment was terminated. Quality of life (QoL) was also assessed at baseline and two months posttreatment. In addition, one of the participants with severe global aphasia was followed up again one and two years posttherapy. Results. For all participants, both rTMS paradigms (1 Hz rTMS and cTBS) generated trends towards improvement in several language skills (i.e., verbal receptive language, expressive language, and naming and reading) one day after treatment and/or two months after therapy. Rated QoL remained stable in three individuals, but for the other three, the communication scores of the QoL were reduced, while two of them also showed a decline in the psychological scores. The participant that was treated with cTBS and followed for up to two years showed that the significant improvement she had initially exhibited in comprehension and reading skills two months after TMS (1st follow-up) was sustained for at least up to two years. Conclusion. From the current findings, it is suggested that inhibitory TMS over the right pTr has the potential to drive neuroplastic changes as a standalone treatment that facilitates language recovery in poststroke aphasia.
Comparison between Heat-Clearing Medicine and Antirheumatic Medicine in Treatment of Gastric Cancer Based on Network Pharmacology, Molecular Docking, and Tumor Immune Infiltration Analysis
Authors: Xu Jiamin , Kang Fuqin , Wang Wei , Liu Shujun , Xie Jianhui , Yang Xiaobo
Published: January 2022

Background. Clinical research found that TCM is therapeutic in treating gastric cancer. Clearing heat is the most common method, while some antirheumatic medicines are widely used in treatment as well. To explore the pharmacological mechanism, we researched the comparison between heat-clearing medicine and antirheumatic medicine in treating gastric cancer. Methods. First, related ingredients and targets were searched, respectively, and are shown in an active ingredient-target network. Combining the relevant targets of gastric cancer, we constructed a PPI network and MCODE network. Then, GO and KEGG enrichment analyses were conducted. Molecular docking experiments were performed to verify the affinity of targets and ligands. Finally, we analyzed the tumor immune infiltration on gene expression, somatic CNA, and clinical outcome. Results. A total of 31 ingredients and 90 targets of heat-clearing medicine, 31 ingredients and 186 targets of antirheumatic medicine, and 12,155 targets of gastric cancer were collected. Antirheumatic medicine ranked the top in all the enrichment analyses. In the KEGG pathway, both types of medicines were related to pathways in cancer. In the KEGG map, AR, MMP2, ERBB2, and TP53 were the most crucial targets. Key targets and ligands were docked with low binding energy. Analysis of tumor immune infiltration showed that the expressions of AR and ERBB2 were correlated with the abundance of immune infiltration and made a difference in clinical outcomes. Conclusions. Quercetin is an important ingredient in both heat-clearing medicine and antirheumatic medicine. AR signaling pathway exists in both types of medicines. The mechanism of the antitumor effect in antirheumatic medicine was similar to trastuzumab, a targeted drug aimed at ERBB2. Both types of medicines were significant in tumor immune infiltration. The immunology of gastric tumor deserves further research.
Analysis of Public Opinion in Colleges and Universities Based on Wireless Web Crawler Technology in the Context of Artificial Intelligence
Authors: Wu WenNing , Deng ZhengHong
Published: January 2022

Wi-Fi-enabled information terminals have become enormously faster and more powerful because of this technology’s rapid advancement. As a result of this, the field of artificial intelligence (AI) was born. Artificial intelligence (AI) has been used in a wide range of societal contexts. It has had a significant impact on the realm of education. Using big data to support multistage views of every subject of opinion helps to recognize the unique characteristics of each aspect and improves social network governance’s suitability. As public opinion in colleges and universities becomes an increasingly important vehicle for expressing public opinion, this paper aims to explore the concepts of public opinion based on the web crawler and CNN (Convolutional Neural Network) model. Web crawler methodology is utilised to gather the data given by students of college and universities and mention them in different dimensions. This CNN has robust data analysis capability; this proposed model uses the CNN to analyse the public opinion. Preprocessing of data is done using the oversampling method to maximize the effect of classification. Through the association of descriptions, comprehensive utilization of image information like user influence, stances of comments, topics, time of comments, etc., to suggest guidance phenomenon for various schemes, helps to enhance the effectiveness and targeted social governance of networks. The overall experimentation was carried out in python here in which the suggested methodology was predicting the positive and negative opinion of the students over the web crawler technology with a low rate of error when compared to other existing methodology.
Experimental Study on the Evolution Mechanism of Landslide with Retaining Wall Locked Segment
Authors: Liu Han-Dong , Chen Jia-Xing , Guo Zhi-Fei , Li Dong-Dong , Zhang Ya-Feng
Published: January 2022

The failure of locked segment-type slopes is often affected by rainfall, earthquake, and other external loads. Rainfall scours the slope and weakens the mechanical properties of rock-soil mass. At the same time, rainfall infiltrates into cracks of slope rock mass. Under the action of in situ stress, hydraulic fracturing leads to the development and expansion of rock cracks, which increases the risk of slope instability. Under seismic force, the slope will be subjected to large horizontal inertial force, resulting in slope instability. In this paper, a self-developed loading device was used to simulate the external loads such as rainfall and earthquake, and the model tests are carried out to study the evolution mechanism of landslide with retaining wall locked segment. Three-dimensional laser scanner, microearth pressure sensors, and high-definition camera are applied for the high-precision monitoring of slope shape, deformation, and stress. Test results show that the retaining wall locked segment has an important control effect on landslide stability. The characteristics of deformation evolution and stress response of landslide with retaining wall locked segment are analyzed and studied by changing the slope shape, earth pressure, and the displacement cloud map. The evolutionary process of landslide with retaining wall locked segment is summarized. Experimental results reveal that as the landslide with retaining wall locked segment is at failure, the upper part of the landslide thrusts and slides and the retaining wall produces a locking effect; the middle part extrudes and uplifts, which is accompanied with shallow sliding; and compression-shear fracture of the locked segment leads to the landslide failure.
Qici Sanling Decoction Suppresses Glutamine Consumption and Bladder Cancer Cell Growth through Inhibiting c-Myc Expression
Authors: Chen Weihua , Wang Weifeng , Zhang Jun , Liao Guoqiang , Bai Jie , Yang Bo , Tan Mingyue , Gong Hua
Published: January 2022

Traditional Chinese medicine (TCM) is widely used as an alternative therapy for cancer treatment in China. Glutamine catabolism plays an important role in cancer development. Qici Sanling decoction (QCSL) suppresses bladder cancer growth. However, the association between QCSL and glutamine catabolism remains unknown. In this study, different doses of QCSL were applied to T24 cells, followed by the measurements of cell viability and apoptosis using CCK-8 and Annexin V/PI assay, respectively. Furthermore, glutamine consumption was detected using the glutamine assay kit. QCSL was observed to inhibit cell growth and induced cell apoptosis in a dose-dependent manner. Analysis of glutamine consumption revealed that QCSL suppressed glutamine consumption in T24 cells. Furthermore, QCSL decreased the mRNA and protein levels of c-Myc, GLS1, and SLC1A5. All these effects induced by QCSL could be alleviated by c-Myc overexpression, indicating c-Myc was involved in the protective role of QCSL in bladder cancer. In addition, QCSL was found to inhibit tumor growth in the xenograft tumor model. The similar results were obtained in tumor samples that protein levels of c-Myc, GLS1, and SLC1A5 were decreased upon treatment with QCSL. In conclusion, QCSL suppresses glutamine consumption and bladder cancer cell growth through inhibiting c-Myc expression.
Remote Sensing Image Fusion Algorithm Based on Two-Stream Fusion Network and Residual Channel Attention Mechanism
Authors: Huang Mengxing , Liu Shi , Li Zhenfeng , Feng Siling , Wu Di , Wu Yuanyuan , Shu Feng
Published: January 2022

A two-stream remote sensing image fusion network (RCAMTFNet) based on the residual channel attention mechanism is proposed by introducing the residual channel attention mechanism (RCAM) in this paper. In the RCAMTFNet, the spatial features of PAN and the spectral features of MS are extracted, respectively, by a two-channel feature extraction layer. Multiresidual connections allow the network to adapt to a deeper network structure without the degradation. The residual channel attention mechanism is introduced to learn the interdependence between channels, and then the correlation features among channels are adapted on the basis of the dependency. In this way, image spatial information and spectral information are extracted exclusively. What is more, pansharpening images are reconstructed across the board. Experiments are conducted on two satellite datasets, GaoFen-2 and WorldView-2. The experimental results show that the proposed algorithm is superior to the algorithms to some existing literature in the comparison of the values of reference evaluation indicators and nonreference evaluation indicators.
Comparison of Efficacy between Acupuncture Therapies in Improving Sacroiliac Joint Malposition: A Systematic Review and Meta‐Analysis
Authors: Liu Liguo , Pan Litao , Tian Minne , Chen Xiuhua , Lu Liming , Xu Guofeng , Sun Jian , Kui Yu
Published: January 2022

Aim. To provide available quantitative evidence of efficacy and safety of acupuncture treatments for improving sacroiliac joint malposition. Methods. Databases such as the China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (CQVIP), Wanfang Database (Wanfang), China Biology Medicine disc (CBMdisc), PubMed, Web of Science, EMBASE, and Cochrane Library were searched by computer to collect the reports on acupuncture treatment of sacroiliac joint malposition from the database creation to July 20, 2021. The selection of included studies, data extraction and coding, and bias risk assessment were conducted independently by two reviewers. RevMan5.4 software was used for meta‐analysis, and the results were expressed as mean difference (MD) or standardized mean difference (SMD), with a confidence interval (CI) of 95%. Results. A total of 10 randomized controlled clinical trials (RCTs) with 1019 participants were included. Their overall quality of methodology was not high, and there may be publication bias. Meta‐analysis showed that the total effective rate of the treatment group was higher than that of the control group (OR = 2.74, 95% CI 2.00 to 3.74, P < 0.00001). The treatment group was better than the control group in improving VAS score (WMD = −1.56, 95% CI ‐2.18 to ‐0.94, P < 0.00001). The ODI score of the treatment group was lower than that of the control group (WMD = −6.04, 95% CI ‐7.05 to ‐5.02, P < 0.00001). With the improvement of the JOA score, the difference of iliac transverse diameter of sacroiliac joint dislocation and the index of sacroiliac joint malposition in the treatment group were better than those in the control group (P < 0.05). There was no significant heterogeneity among the studies. Conclusion. Acupuncture may have therapeutic advantages in improving sacroiliac joint malposition. Acupuncture and acupotomy provide a safe way to improve the related clinical symptoms and functional disorders in activity of sacroiliac joint dislocation. However, due to the low quality of the included literature, this conclusion still needs to be further verified by more high‐quality and large‐sample RCTs.
A Novel Online Education Reform Model Based on Risky Decision-Making under the Situation of Internet Plus
Authors: Lv Yao
Published: January 2022

In the new situation of Internet plus, information technology has been widely applied in education, and hence online education has attracted wide attention from all walks of life. Today’s society is a risk society, and risk is everywhere. Online education reform is also risky, which is determined by many reasons. Some risks will cause certain losses to the online education reform, so based on risky decision-making, it is necessary to carry out online education reform under the new situation of Internet plus. At first, the risky decision-making in online education reform is analyzed, which is the risk of online education reform in risk society and the allocation logic of online education reform. Then, taking interval type-2 fuzzy logic (IT2FL) as the information environment, this study proposes the optimal risky decision-making method based on IT2FL utility functions, IT2FL entropy, and risk preference factor of online education reform to solve the multipath risky decision-making problem of online education reform. Finally, the experimental results show that, in the risky decision-making model, the decision-maker’s risk preference has an impact on the path weight and the ranking of the scheme, and the idea has a certain reference role for risky decision-making. Compared with the three benchmarks, the proposed method has the fewest ranking time with the same ranking results.
Rolling Bearing Fault Diagnosis Based on Component Screening Vector Local Characteristic-Scale Decomposition
Authors: Guan Tengfei , Liu Shijun , Xu Wenbo , Li Zhisheng , Huang Hongtao , Wang Qi
Published: January 2022

The fault vibration signal of a bearing has nonstationary and nonlinear characteristics and can be regarded as the combination of multiple amplitude- and frequency-modulation components. The envelope of a single component contains the fault characteristics of a bearing. Local characteristic-scale decomposition (LCD) can decompose the vibration signal into a series of multiple intrinsic scale components. Some components can clearly reflect the running state of a bearing, and fault diagnosis is conducted according to the envelope spectrum. However, the conventional LCD takes a single-channel signal as the research object, which cannot fully reflect the characteristic information of the rotor, and the analysis results based on different channel signals of the same section will be inconsistent. To solve this problem, based on full vector spectrum technology, the homologous dual-channel information is fused. A vector LCD method based on cross-correlation coefficient component selection is given, and a simulation analysis is completed. The effectiveness of the proposed method is verified by simulated signals and experimental signals of a bearing, which provides a method for bearing feature extraction and fault diagnosis.
The Aptamer Functionalized Nanocomposite Used for Prostate Cancer Diagnosis and Therapy
Authors: Feng Xiaoqian , Zhu Yinxing , Wang Fujin , Guo Ting , Dou Xiaofeng , Lin Mei , Tian Weizhong
Published: January 2022

Prostate cancer is one of the major malignancies that threaten men’s health all over the world. Due to the lack of specific symptoms and signs in the early stage, as well as the limitations of existing detection methods, it is difficult to achieve early diagnosis for prostate cancer. As short single‐stranded oligonucleotides (DNA or RNA) with specific 3D structure which can be produced using an in vitro selection process termed systematic evolution of ligands by exponential enrichment (SELEX), aptamers can specifically bind to the corresponding targets. They have become a class of novel targeting ligand for accurate diagnosis and effective treatment of cancer. Owing to distinctive physicochemical features, and some other special properties such as easy modifiability, good biocompatibility, being easily coupled with other ligands, nanomaterials are extensively used in biological medical field research. Enlighteningly, the combination of aptamers with nanomaterials, including metal nanoparticles, nanosilica, quantum dots, and carbon nanomaterials, can enhance the ability of nanomaterials to recognize tumor cells, which is beneficial to overcome the shortcomings such as low sensitivity in early detection and lack of specificity of traditional antineoplastic drugs, thus, clinically helpful to improve the early metaphase diagnosis rate, providing a technical guarantee for the “personalized treatment” strategy for prostate cancer. Herein, we mainly review the basic and applied research of aptamer functionalized nanocomposite in prostate cancer diagnosis and treatment, including biosensing, bioimaging, and cancer therapy, hoping to provide new ideas for prostate cancer diagnosis and treatment.
Improved Arabic Alphabet Characters Classification Using Convolutional Neural Networks (CNN)
Authors: Wagaa Nesrine , Kallel Hichem , Mellouli Nédra
Published: January 2022

Handwritten characters recognition is a challenging research topic. A lot of works have been present to recognize letters of different languages. The availability of Arabic handwritten characters databases is limited. Motivated by this topic of research, we propose a convolution neural network for the classification of Arabic handwritten letters. Also, seven optimization algorithms are performed, and the best algorithm is reported. Faced with few available Arabic handwritten datasets, various data augmentation techniques are implemented to improve the robustness needed for the convolution neural network model. The proposed model is improved by using the dropout regularization method to avoid data overfitting problems. Moreover, suitable change is presented in the choice of optimization algorithms and data augmentation approaches to achieve a good performance. The model has been trained on two Arabic handwritten characters datasets AHCD and Hijja. The proposed algorithm achieved high recognition accuracy of 98.48% and 91.24% on AHCD and Hijja, respectively, outperforming other state-of-the-art models.
Abstract IA-01: Health disparity research: The new frontier of research
Authors: Winn Robert A.
Published: January 2022

In 2020, the AACR's U.S. Cancer Disparities Progress Report showed that the there is still a significant gap in cancer incidence and mortality between white Americans and other racial and ethnic groups. That's not because the science hasn't progressed or because people of color are biologically predisposed to cancer. It's because the systems and structures put in place decades ago continue to harm the health of racial and ethnic minorities. Red-lining in the 1930s created segregated housing, and then the creation of the national highway system decimated majority-Black neighborhoods, leaving them treeless, polluted, and lacking healthy food and medical facilities. As a result, people living in these neighborhoods are more likely to get cancer and also more likely to die from it. So, when COVID-19 hit, many of us were not surprised that communities of color were disproportionately affected. And the current situation with COVID-19 vaccines is a great demonstration that while science is necessary for improving health, it's not sufficient. Those amazingly effective vaccines can't keep hospitals from being overwhelmed if a large chunk of the population won't get the shot, just as advances in cancer screening and treatment can't end disparities if they're predominantly going to wealthy white people. This realization has been one of our blind spots as scientists and physicians. Not only must work toward equitable access to care, but we must also work on building trust in medicine, which we do by demonstrating that we're trustworthy. There's a science to it, though we're going to have to allow for greater flexibility and messiness than we're accustomed to.

Citation Format: Robert A. Winn. Health disparity research: The new frontier of research [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA-01.
Prevalence of Food Allergy among Schoolchildren in Lebanon
Authors: Sakakini Jana , Irani Carla , Bikai Rana , Sahyoun Gretta , Hallit Souheil , Salameh Pascale , Dano Dominique
Published: January 2022

Introduction: Food allergy (FA) is a global health problem with an ongoing rise in prevalence, especially in developed countries. It has been reported to be most prevalent in children, although cases in adults have been increasing as well. FA may lead to life-threatening clinical manifestations. Data in Lebanon and the Middle East are limited. To our knowledge, few studies tackled its prevalence in children in this region. Aim: This study aims at determining self-reported prevalence of FA in schoolchildren (ages 3–17 years) in Lebanon and describes its characteristics. Method: Throughout this cross-sectional study, 5 schools from 3 different governorates in Lebanon (Beirut, Mt. Lebanon, and Beqaa) were contacted to participate and 5,312 questionnaires were sent out to be completed by the parents and sent back to the school during May 2019. Results: 2,610 questionnaires were collected (49.13%). A hundred and forty-eight (6%) children reported to have FA, 58% were males. 80% of them were breastfed, 51% were diagnosed between the ages of 2 and 14 years. Common allergens included cow’s milk and milk products (22.46%), fruits and vegetables (16.58%), eggs (8.02%), and nuts (5.88%). Allergic symptoms included skin reactions (45.08%), gastrointestinal (GI) symptoms (29.53%), respiratory symptoms (14.51%), and systemic symptoms (10.88%). 82% of the population with FA has sought professional advice, out of which 54% were confirmed by a physician. Common methods of diagnosis were IgE test (35.71%), food elimination (27.92%), and skin prick test (18.83%). χ2 analysis has shown that a higher percentage of children with FA had skin reactions (58.8%, p = 0.033) and GI symptoms (30.41%, p = 0.047). A higher percentage of children with allergies were breastfed. No relation between the presence of FA and delivery mode was observed. Conclusion: This study has shown that the self-reported prevalence of FA among Lebanese schoolchildren is 6%, and it was correlated with skin and GI symptoms. The most common allergen was cow’s milk. A higher proportion of children with FA were breastfed. No association between the mode of delivery and FA was found. Larger studies are needed to confirm the above findings.
A Case of Angioid Streaks in Congenital Dyserythropoietic Anaemia Type II
Authors: Doolan Emer , Ryan Andrea
Published: January 2022

The authors describe a case report of retinal angioid streaks (AS) in a patient with congenital dyserythropoietic anaemia (CDA) type II and compare the retinal findings to those of an affected first-degree relative without ocular manifestations of the disease. A 52-year-old man with a confirmed diagnosis of CDA type II has been dependent on treatment with regular transfusions and chelating agents. He presents with bilateral retinal AS. The subject’s brother, who also has CDA type II, underwent splenectomy in childhood, and has required no treatment since then. He has no ocular manifestations of the disease. To the authors’ knowledge, this is only the second time that the presence of retinal AS has been reported in a case of CDA type II. It has been reported more frequently with CDA types I and III. The milder course of disease in the subject’s brother likely accounts for the differing retinal findings. The authors explore the pathophysiology of AS in this disease, and the differential diagnosis of chelating agent toxicity. Diagnostic uncertainty around retinal findings can lead to withholding of essential systemic treatment and inappropriate ophthalmological follow-up. It is recommended that all patients with CDA undergo eye examinations.
Could the PARIS Risk Scores Be Useful for the Choice of Triple versus Dual Antithrombotic Therapy in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention?
Authors: De Luca Leonardo , Bolognese Leonardo , Rubboli Andrea , Lucci Donata , Gabrielli Domenico , Colivicchi Furio , Gulizia Michele Massimo ,   on behalf of the MATADOR-PCI Investigators
Published: January 2022

Introduction: Current guidelines recommend dual antithrombotic therapy (DAT) for the majority of patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) and suggest a short course of triple antithrombotic therapy (TAT) for those at very high thrombotic risk (TR) but low bleeding risk (BR). Methods: We analyze if the PARIS ischemic-hemorrhagic scale could be useful for the choice of antithrombotic strategy in patients with acute coronary syndromes and AF treated with coronary stenting enrolled in the prospective, observational, nationwide MATADOR-PCI study. Results: Among the 588 patients discharged alive, a TAT was prescribed in 381 (64.8%) and DAT in 52 (8.8%) patients. According to the PARIS scoring system, 142 (24.2%) were classified as low, 244 (41.5%) as intermediate, and 292 (34.3%) as high TR. In parallel, 87 (14.8%) were categorized in the low, 260 (44.2%) in the intermediate, and 241 (41.0%) in the high-risk stratum for major bleedings. Crossing the various strata of the two PARIS risk scores, the largest group of patients consisted of those at high TR and BR (n = 130, 22%), followed by those at intermediate risk according to both scores (n = 122, 21%). At discharge, TAT was mainly used in patients at intermediate to high BR, while DAT in those at intermediate to high TR but low BR, according to the PARIS score. Conclusion: Our data suggest that some variables associated with increased TR or BR are poorly considered in the daily practice, while the use of PARIS scales could help in the implementation of guidelines’ recommendations.