bluuebunny/crossref_metadata_2025 huggingface dataset:
The Optimization of Sulphide Oxidizing Bacteria (SOB) for Oil Corrosivity Reduction at Indramayu Coast, The Northern Coastal Area of West Java
Authors: Ihsan Yudi Nurul , Fellatami Kalysta , Permana Rega , Mingguo Jiang , Pribadi Tri Dewi Kusumaningrum
Published: August 2022

Highlight Research

First NR-SOB from Indramayu coast was successfully isolated and identified.
Bactrerial characterization morphologically and biochemically, foster with in situ hybridization confirm the isolate was Thiobacillus denitrificans, and Arcobacter sp.
Both isolate, Thiobacillus denitrificans and Arcobacter sp., were able to grow in sulphide rich environment in the presence of essential nutrient
Thiobacillus denitrificans and Arcobacter sp. exhibit an outstanding sulphide oxidation ability up to 100% in the presence of nitrate.

 
Abstract
Crude oil production triggers the formation of hydrogen sulphide, also known as souring, which is extremely toxic and corrosive to the environment. It additionally give an adverse consequence to aquatic, terrestrial, and human existence. Studies of hydrogen sulphide reduction in sediments polluted by crude oil have been carried out recently to investigate the capability of indigenous Nitrate-Reducing Sulphide Oxidising Bacteria, hereinafter referred to as NR-SOB, as bioremediation agents. The experiments utilised hydrogen sulphide with 200 µM concentration combined with NO3 with different concentrations of 100 µM, 200 µM, and 300 µM. Measurements of the hydrogen sulfide concentrations were observed up to 48 hours within the experimental period. The SOB used in this study were taken from Balongan Bay at Indramayu coast using Nansen bottle to carry out water sample. The sulphide-oxidising ability of SOB was then evaluated at room temperature in control environment. Methylene blue method was applied to monitor the sulphide concentration. The results showed a complete removal of hydrogen sulphide concentrations in 48 hours accompanied with gradual drops of nitrate in all experiment series. Sulphide oxidation rate was detected to appear between 6.8 and 10.2 fmol/cell/hour. Measurements of cell abundance after 48 hours showed 6.2 x 105, 7.5 X 105, and 8.2 X 105 cell/ml from Experiments I, II, and III respectively. Using MSS selective medium, the bacteria were identified as Thiobacillus denitrificans and Arcobacter sp. Overall, the isolated NR-SOB from the coast of Balongan Bay, Indramayu proves to be a promising candidate for sulphide controls and mitigation.
Vascular graft infections
Authors: Hemelrijck Mathias Van , Sromicki Juri , Husmann Lars , Rancic Zoran , Hasse Barbara , Carrel Thierry P.
Published: August 2022

Vascular graft infections are rare complications after surgical and endovascular treatment of aortic diseases. This condition is characterized by complexity in diagnosis and medico-surgical management. Moreover, even if properly treated, morbidity and mortality rates are high. Although several advances have been made over the years and guidelines of treatment have been published, there is still debate on the optimal care for this disease. With local microbiological patterns and multiresistant strains conditioning antimicrobial treatment as well as several surgical debridement techniques in the armamentarium, it is difficult to offer recommendations that can be generalized for every single case. In this review, we aim at describing thoracic and abdominal vascular graft infections and providing current information on diagnosis, medical treatment, and surgical management.
Relationship between content marketing and brand loyalty of New-China-Chic brand based on nationalism
Authors: Chen Xi , Xu Jie
Published: August 2022

This paper explores the relationship between content marketing and consumer brand loyalty to the ‘New-China-Chic’ brand. It constructs a structural equation model, Through questionnaires distributed to the fan groups of various brands and offline stores, results show that the four different dimensions of content marketing strategy, namely the culture, entertainment, emotion and interaction, are the main factors affecting consumers' loyalty to the ‘New-China-Chic’ brand. Among them, emotional content and cultural content??= 0.304??= 0.209) have a strong impact on brand loyalty. Brand identity also plays a strong intermediary role in the relationship between the four different dimensions of content marketing and brand loyalty. Moreover, the data shows that consumer ethnocentrism has a significant regulatory effect on brand identity and brand loyalty in cultural content and emotional content, while interactive content and entertainment content have a weak impact.
Non-Archimedean Welch Bounds and Non-Archimedean Zauner Conjecture
Authors: Krishna K. Mahesh
Published: August 2022

Let $\mathbb{K}$ be a non-Archimedean (complete) valued field satisfying \begin{align*} \left|\sum_{j=1}^{n}\lambda_j^2\right|=\max_{1\leq j \leq n}|\lambda_j|^2, \quad \forall \lambda_j \in \mathbb{K}, 1\leq j \leq n, \forall n \in \mathbb{N}. \end{align*} For $d\in \mathbb{N}$, let $\mathbb{K}^d$ be the standard $d$-dimensional non-Archimedean Hilbert space. Let $m \in \mathbb{N}$ and $\text{Sym}^m(\mathbb{K}^d)$ be the non-Archimedean Hilbert space of symmetric m-tensors. We prove the following result. If $\{\tau_j\}_{j=1}^n$ is a collection in $\mathbb{K}^d$ satisfying $\langle \tau_j, \tau_j\rangle =1$ for all $1\leq j \leq n$ and the operator $\text{Sym}^m(\mathbb{K}^d)\ni x \mapsto \sum_{j=1}^n\langle x, \tau_j^{\otimes m}\rangle \tau_j^{\otimes m} \in \text{Sym}^m(\mathbb{K}^d)$ is diagonalizable, then \begin{align}\label{WELCHNONABSTRACT} \max_{1\leq j,k \leq n, j \neq k}\{|n|, |\langle \tau_j, \tau_k\rangle|^{2m} \}\geq \frac{|n|^2}{\left|{d+m-1 \choose m}\right| }. \end{align} We call Inequality (\ref{WELCHNONABSTRACT}) as the non-Archimedean version of Welch bounds obtained by Welch [\textit{IEEE Transactions on Information Theory, 1974}]. We formulate non-Archimedean Zauner conjecture.
Impact of the agricultural division on the Iraqi Balance of Payments using VAR analysis
Authors:   Middle Technical University, Makki Mohammed Rasool , Kadhim Ruaa Naseer ,   Wasit University, Abed Alyaa Razzaq ,   Wasit University
Published: August 2022

The research aims to identify the impact of the agricultural division on the Iraqi balance of payments (IBP) for the period of 2004-2020. There is an integration between the two variables: the added value of the Iraqi agricultural division and the current account of the Iraqi balance of payments during the study period. VAR analysis has been employed to explain how the agricultural division can affect the Iraqi balance of payments. The statistical model has been investigated using unit root test along with the causality test, which was conducted based on the ARDL methodology. The study results indicated that it was needed to provide all facilities and privileges to investors in the agricultural division to reach self-sufficiency in basic agricultural crops. It was proposed to increase government spending on the non-oil sectors in general and the agricultural division to diversify the sources of income for the Iraqi economy and reduce dependence on oil as a source of basic income
Financial inclusion as mediator in the relationship of social capital and financial literacy towards business performance of the trade sector SMEs in Pekanbaru, Indonesia
Authors:   Institute of Business and Technology Pelita Indonesia, Mimelientesa Irman , Budiyanto  ,   Sekolah Tinggi Ilmu Ekonomi Indonesia, Suwitho  ,   Sekolah Tinggi Ilmu Ekonomi Indonesia
Published: August 2022

This study analyzes SMEs’ performance problems in the trade sector in Pekanbaru by using several internal company factors to build a competitive strategy till the year 2021. The variables used in this study consisted of social capital, financial literacy, financial inclusion, and business performance. The study used 300 SMEs consisting of 26 wholesalers and 274 retailers in Pekanbaru, Riau. We used a structural equation model (SEM) approach with AMOS for hypothesis testing. The results show that social capital and financial literacy have a significant direct effect on the SME businesses’ performance in the trade sector in Pekanbaru. This shows that social capital and financial literacy are two determining factors for the success of SME businesses. However, social capital does not affect business performance indirectly through the role of financial inclusion
Formation of a complex method for analyzing multidimensional production data of a processing plant
Authors:   Belgorod State National Research University, Ivashchuk Olga , Ivashchuk Orestes ,   Belgorod State National Research University, Fedorov Vyacheslav ,   Belgorod State National Research University, Rodionov Alexander ,   Belgorod State National Research University, Shtana Albert ,   Belgorod State National Research University
Published: August 2022

We discuss the development of a comprehensive data analysis method which allows increasing the accuracy of predicting the performance of roller mill of processing plant (RP) mining and processing plant (GOK) when you change the properties of incoming raw materials for processing. The described method includes primary data processing, determination by statistical analysis methods and data mining algorithms of the most significant factors affecting the resulting parameter, development of mathematical models based on correlation regression and factor analysis, analysis and confirmation of the quality of forecasting by a neural network. The systematization and coordination of production data was carried out, the generated database was processed using statistical and intellectual analysis methods, the physical and chemical parameters of the input raw materials and processed ore that have the greatest impact on the mill productivity were determined, mathematical models were formed to determine the expected productivity, their quality and applicability limits were evaluated, the error in predicting the mill productivity for various mineralogical compositions of the processed ore was determined. The significance of the parameters used in the models is checked by the algorithms of intelligent analysis. The verification of the used models for predicting mill performance by an artificial neural network is carried out by comparing the series of predicted values of the resulting factor obtained by different models
CEO overconfidence, investment decisions and firm value in Indonesia
Authors:   Lampung University, Fionita Ita , Kufepaksi Mahatma ,   Lampung University, Hasnawati Sri ,   Lampung University
Published: August 2022

This study examines the effect of CEO overconfident behaviour on investment decisions with a behavioural finance theory-based approach, then, examines the effect of investment decisions on firm value with a traditional finance theory approach. Managers who are overconfident are the cause of investment deviations, investment sensitivity, and overestimated project returns that actually affect the value of the company. This study uses 175 non-financial companies on the Indonesia Stock Exchange led by the same CEO during the 2015-2019 period. Data analysis in this study was carried out using the Partial Least Square (PLS) method. PLS is a method of solving structural equation modelling (SEM) which in this case (according to the research objectives) is more precise than other SEM techniques. The results showed that the CEO’s overconfident behaviour had a significant effect on firm value with investment decisions as a mediating variable. This means that the CEO’s overconfident behaviour is able to increase firm value through investment decisions as a mediating variable
Hiring in pharmaceutical organizations: procedural aspects of personnel assessment
Authors:   Belgorod State National Research University, Tretyakova Larisa , Spichak Irina ,   Belgorod State National Research University, Zhirova Irina ,   Belgorod State National Research University, Tkhorikov Boris ,   Belgorod State National Research University, Evtushenko Olena ,   National University of Pharmacy
Published: August 2022

In modern socio-economic conditions, in order to achieve strategic goals, a pharmaceutical organization needs highly qualified personnel with certain characteristics, the necessary potential to effectively perform their professional duties. The lack of effective tools for assessing and developing personnel is one of the significant reasons for limiting the growth of financial results and the efficiency of the pharmaceutical organization. The result of the study is an assessment procedure when hiring personnel, taking into account the conditions of a highly competitive ambience, contributing to a significant increase in the productivity and quality of employees’ work, decisions made, and, therefore, an increase in the value of human resources of the pharmaceutical organization
Investment decisions, financing and dividends to increase firm value: a case study of manufacturing companies in Indonesia
Authors:   Syiah Kuala Darussalam University, Meutia Rita , Apridar  ,   Syiah Kuala Darussalam University, Mursidah  ,   Malikussaleh University, Mastuti Rini ,   Samudra University, Fuad Muhammad ,   Samudra University
Published: August 2022

This study aims to determine the direct relationship of firm value with investment decisions, funding, dividends, and agency costs. The method used in this research is descriptive. The object under study is the manufacturing companies listed on the Indonesia Stock Exchange IDX during 2008-2017, totalling 108 companies. Data was collected using a survey method on cross-sectional and time-series data. The data analysis method used the Partial Least Square (PLS) technique. Tobin’s Q is used as a parameter of firm value. CAP/BVA as an investment decision parameter, DER as a funding decision parameter, DPR as a dividend decision parameter, and FCF as an agency cost parameter. The results directly influence the model that investment decisions, funding decisions, dividend decisions, and agency costs positively affect firm value. The indirect impact states that agency costs significantly mediate the relationship between investment decisions, funding decisions, and dividends on firm value.
Semantic mapping technique: development of advertising content
Authors:   Belgorod State National Research University, Tkhorikov Boris , Pirogova Marina ,   Belgorod State National Research University, Zakharov Victor ,   Belgorod State National Research University, Gerasimenko Olga ,   Belgorod State National Research University, Osadchaya Svetlana ,   Belgorod State National Research University
Published: August 2022

The paper considers author’s technique named Semantic Mapping intended for the development of advertising content. The technique was developed using interdisciplinary approach - neuromarketing, swarm intelligence, sensory, behavioral and experiential marketing focusing on imaginative thinking and emotional reactions of consumers essential in advertising content. This allows to create viral content based on creative decisions interesting to the audience and applicable to omnichannel communication. Advertising content is created in three stages: determining the limitations of advertising effectiveness, formulating the key idea (content), creating and testing the advertising. The Semantic Mapping technique can be used in marketing activities of various companies, including small businesses, and is notable for its low labor intensity and low budget.
The theoretical heritage of marketing management: a retrospective analysis
Authors:   Belgorod State National Research University, Shumakova Irina , Voronov Aleksandr ,   Belgorod State National Research University, Peresypkin Andrey ,   Belgorod State National Research University, Danilova Elena ,   Belgorod State National Research University
Published: August 2022

The paper presents scientific views reflecting marketing management specifics which explains the timely character of the study. The argumentative logics has been used to verify the hypothesis about the impossibility to substantiate promising lines of marketing management research without identifying blanc spots in the scientific basis of respective area of expertise. Systemic chronological and retrospective analysis of the theoretical works was employed in order to achieve the results. The findings give a detailed explication of the scientific landscape which reflects the viewpoints of marketing management issues. The main conclusion is that the thesis of the «ideal marketing management» concept which allows for the requirements of all contemporary marketing systems participants to be fully met as of today, has a fragmentary character. The findings can be employed in further theoretical research in marketing and other fields of knowledge.
Generic entrepreneurship education program design for universities
Authors:   Sebelas Maret University, Susilaningsih
Published: August 2022

Universities in Indonesia have implemented entrepreneurship education, and some have committed to developing a good entrepreneurial culture. This study aims to design an entrepreneurship education program as a generic model applicable to universities. The method in this research is qualitative descriptive with a case study approach. The research was conducted at four universities in Indonesia. Data was obtained using in-depth interviews and observation. Data analysis uses triangulation, namely collecting data, validating data, presenting data, and drawing conclusions. The study results indicate that the entrepreneurship education program model should be considered, and one university must own it. The implementation of entrepreneurship education programs must be carried out in stages, continuously, and integrated manner. The entrepreneurship education model offered is generic. Entrepreneurial culture will be more developed because it is interpreted or perceived as an attitude or mental character that helps in all work. It has been proved that the implementation of entrepreneurship education needs to consider management factors such as university commitment, entrepreneurial climate, main activities, supporting activities, infrastructure, facilities, and cooperation.
The Role of food aid and livelihood interventions in mediating the relationship between household’s resilience and economic empowerment
Authors:   Hungarian University of Agriculture and Life Sciences, MATE, Samia Nassar , Naárné Tóth Zsuzsanna ,   Hungarian University of Agriculture and Life Sciences, MATE, Vasa Laszlo ,   Szechenyi Istvan University
Published: August 2022

The concept of resilience has been utilized to examine more complex ecological and socioeconomic systems such as agri-food systems in developing countries. Gaza has one of the high unemployment rates globally, therefore keeping people imprisoned in poverty and dependent on external support to existing. The strategy for poverty reduction in Gaza primarily consists of giving food aid or multi-purpose cash-based assistance and livelihood projects; nevertheless, this does not reduce unemployment or poverty in the long term. Non-Governmental Organizations (NGOs) have increased their efforts to provide more effective and comprehensive interventions to the affected populations, especially in the Gaza Strip. The research implemented a quantitative methodology distributed to over 300 household benefited from food aid and livelihood interventions through the NGOs in Gaza Strip. The questionnaire had been constructed based on the Likert Scale ranging from 1 (Strongly Agree) to 5 (Strongly Disagree). The data had been treated using SPSS statistical tool and AMOS for structural equation modeling and analysis to study the mediating effect of food aid and livelihood interventions on the relationship between household resilience and economic empowerment in the Gaza Strip. The research found that the resilience ability of many families in the Gaza Strip has increased because of the humanitarian assistance provided by NGOs, which lead to reducing poverty and household resilience plays a vital role in minimizing poverty and alleviating suffering through empowering and engaging them in the economy. The research also found that food aid tends to critically impact the relationship between household resilience and economic empowerment. NGOs play an essential role in engaging the poor in the economy through providing food security and encouraging new investments and efforts to improve help effectiveness via greater coordination among players involved in the implementation and better planning, targeting, and providing aid to people in Gaza Strip. The research findings also showed that livelihood interventions mediate the relationship between household resilience and economic empowerment in Gaza Strip. The structural model supports that the livelihood interventions modulated the association between household resilience and economic empowerment.
Whole-of-nation Moral Learning by Spiritual Hearts: A Case of Brunei’s Evolving Education System
Authors: Haji Tarip Mohammad Iznan , Abu Bakar Nur Firdaus , Ash’ari Zuraihi , Zulkifli Fatin , Marsidi Muzhafar
Published: August 2022

The role of the spiritual heart in transformation and reformation is vital. However, the dynamism of change emanating from the heart is less understood. Using the work of al-Ghazālī (d. 505/1111), this paper centralises the noetic of the spiritual heart and its roles as a learning medium and a change agent. The heart is then conceptually operationalised within the national settings, particularly its role in whole-of-nation moral learning. This is further illustrated by a whole-of-nation moral learning trajectory situated within Brunei’s governance context, which is the (re)Islamisation of the national education system during three periods: pre-independence 1984, post-independence, and the new norm. The case showed the important roles of virtuous leaders to push for moral changes, followers to also engage in moral learning to suppress immoral learning, structures and cultures to be institutionalised to perpetuate moral learning, and selective international relations to catapult local progress.
Sufi Elements in Ki Hadjar Dewantara’s Education Method
Authors: Taufikin Taufikin
Published: August 2022

The 5.0 social era has changed the face of global education, including in Indonesia, which has given impacts to its young generation. As a matter of fact, the Indonesian youths merely use their intellectual skills to explore the technological advancement while neglecting the values of virtue, character, and attitude. Thus, it is necessary to recall the thoughts of the Indonesian prominent scholar Ki Hadjar Dewantara who combined multidiciplinary sciences and Indonesian local values as a reference to solve the aforementioned problem. This study is a library research which aims at investigating thoroughly his thoughts, especially ones concerning with the educational theories as well as interpreting the unstructured existing methods used in Indonesian education. The results show that Ki Hadjar Dewantara presented educational ideas from the perspective of multidiciplinary sciences, especially from Sufi Elements in Islam. Ki Hadjar Dewantara introduced this method in three levels: Firstly, children aged 0-7 can be given sharia-packaged exemplary and habituation methods. Secondly, children aged 7-14 can be given hakikat method which applies reward and punishment. Thirdly, students aged 14-21 can be given tirakat and ma’rifat methods which apply physical and mental learning experiences.
Redefinition of Religious Nation-state; Tracing Textual Doctrine and its Impact on Religious Violence in Indonesia
Authors: Fithriyyah Mustiqowati Ummul , Umam Muhammad Saiful , Astuti Atika Windi , Alkadafi Muammar
Published: August 2022

This paper elaborates on the roots of textual indoctrination in religious violence. This study is important to redefine the concept of religious nation-state in order to avoid the distortion of religious texts’ understanding that can lead to religious violence. This research uses a literature approach. The results of this study state that 1) religious violence is divided into three, namely: internal violence of religious communities, violence between religions and forces outside of religion such as power regimes, and violence between religious communities, 2) Interpretation of religious texts are often obscured by people who want to use it as a tool to legalize violent acts. The deconstruction of the verses of the Quran against the justification of radicalism is often associated with verses describing warfare, identified with the meaning of jihad in the Way of Allah, which is contained in At-Taubat verse: 24, Al-Hajj verse: 78, Al-Mumtahanah verse: 1, Al-Ankabut verse: 6. Whereas in term of warfare stated in the Al-Baqarah verse: 190, it is clear that the only war that is permitted is only for the purpose of defense, not for offense so let alone to take innocent victims, 3) Interpretation of the meaning of truth often triggers the justification of religious violence. This is because every religion has its own scriptural doctrines which lead their believers into the belief that their religion is the most correct one. However, we must not force other believers into believing what we believe as the truth.
Two Uncommon Complications Related to Suture Knots After Meniscal All-Inside Suture Repair
Authors: Tanaka Ayaka , Tsujii Akira , Shimomura Kazunori , Yonetani Yasukazu , Hamada Masayuki
Published: August 2022

Case:

A 17-year-old male patient suffered a radial lateral meniscus tear and underwent an arthroscopic all-inside suture repair. After 7 months, the patient experienced catching. Magnetic resonance imaging and computed tomography revealed an intra-articular loose body without calcification, which was removed surgically. The excised specimen was histopathologically confirmed to be a necrotic meniscus fragment with a suture knot. In addition, cartilage damage because of suspected impingement by a residual suture knot was observed. After removing the loose body and knot, the patient's symptoms were relieved, and he returned to sports.

Conclusion:

Suture knot-related complications should be considered while performing meniscal repairs.
Delirium current practice among Intensive Care Units Doctors, Khartoum
Authors: El-Raheem Ghada Omer Hamad Abd , Hamid Sheema Hamid Seidna , Abdallah Mudawi Mohammed Ahmed
Published: August 2022

Delirium is a brain dysfunction that is characterized by attention and cognition disturbances in a fluctuating pattern. International guidelines recommend daily screening of delirium. The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and the Intensive Care Delirium Screening Checklist (ICDSC) were the most commonly used for delirium assessment. The reasons why this study was developed were to identify the barriers and gaps in knowledge and practice. Multi-center Hospital-based Cross-Sectional study was developed. Multistage sampling technique was used. 72 ICU doctors were randomly selected. Statistical analysis was performed through chi-square test to determine association among variables. It was considered significant when p ≤ 0.05. More than 70% of doctors were ≤ 30 years and females. 69.4% had < 1year experience. 94.4% worked in medical ICUs. Less than 20% of the doctors used delirium assessment tools with a statistically significant difference based on experience (p=0.012). 13.9% had not assessed delirium regularly. Non-pharmacological management was applied by 76.4% of the doctors, communication with patients was the most frequent (75%). Haloperidol was the most used agent (83.3%). 40.3% of doctors had not stopped delirium medications on ICU discharge. Regular assessment of delirium was applied. Yet, the use of validated assessment tools was not common. Non-pharmacological management of delirium is important which is mostly done. Our doctors prescribed anti-psychotics for treatment of both forms of delirium and almost half of them did not stop medications on ICU discharge. Medication reconciliation and contact with the next in-charge of patients is important.
Wire Arc Additive Manufacturing Of 5356 Aluminum Alloy
Authors: KARAYEL Elif , BOZKURT Yahya , ÖZDEMİR Cezmi , KALENDER Murathan
Published: August 2022

Additive manufacturing technology is a new technology that is considered to be a technological revolution in the manufacturing industry. It has advantages such as design flexibility, saving material and time, producing low-density and high-strength parts. Due to these advantages it is used in many sectors such as aviation and automotive. The additive manufacturing method can be integrated into different welding methods. One of these technologies is wire arc additive manufacturing (WAAM). Metal inert/active gas (MIG/MAG) or tungsten inert gas (TIG) welding methods are generally used in this method. The basic principle of the WAAM method is to melt the raw material in the form of wire with electric arc heat and deposit it in layers on top of each other. The fact that large-sized and complex parts can be produced without any problems, almost no waste, and being economical compared to other metal additive manufacturing methods has made this technique a demanding production method.In this study, AA5356 aluminum alloy wires with a diameter of 2.4 mm were deposited on plates under argon gas by TIG welding method and jointed aluminum parts were produced with different welding parameters. As a result of tests and microstructure investigations, it was determined that the samples prepared parallel and perpendicular to the weld seam direction showed different behavior in terms of mechanical properties. These results were supported by the microstructure and compared with the parts produced by traditional methods. In addition mechanical tests and microstructural examinations were supported by EBSD, EDS and AFM analyzes.
The current situation of mental health education and its influencing factors among the elderly migrant population in China: A cross-sectional study
Authors: Wang Wanchen , Song Jia , Fan Chengxin , Li Qiusha , Ma Dongping , Yin Wenqiang
Published: August 2022

Background
Population mobility in China has increasingly included the middle-aged and elderly populations. Relatedly, the lack of mental health education among China's elderly migrant population is still an important but neglected problem. This study aims to understand the current situation of mental health education received by the elderly migrant population in China and to explore the related influencing factors.
Methods
This cross-sectional study included 5,729 elderly migrants who participated in the 2017 China Migrants Dynamic Survey. The covariates included four components: demographic and socioeconomic characteristics, mobility factors, public health service utilization, and social integration factors. Data were analyzed using the chi-square test for single factors and a binary logistic regression model for multiple factors.
Results
A total of 1672 elderly migrants received mental health education, for an acceptance rate of 29.2%. Educational methods included promotional materials (paper, film, and television), bulletin boards/electronic displays, public health consultations, health-related lectures, individualized face-to-face consultations and community SMS/WeChat/websites, which had been accessed by 90.1%, 80.2%, 70.0%, 67.5%, 48.8%, and 39.4% of the sample, respectively. Regression analysis showed that the older migrant population who had an average monthly household income > 3000 CNY, self-rated their health as healthy, had chronic diseases, had heard of National Basic Public Health Services, had established health records, were willing to integrate into the local population, and were highly involved in the community were more likely to receive mental health education. Older migrants who were ≥ 70 years old, had an elementary school education or below, had difficulties in the local community, migrated ≥ 11 years prior, moved for their offspring, and moved across provinces were less likely to receive mental health education.
Conclusions
The elderly migrant population does not accept mental health education well, and the means of obtaining educational assistance are relatively limited. Mental health interventions should be tailored to the characteristics of the migrant elderly population to increase mental health literacy and meet their psychological needs.
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis
Authors: Peng Tingwei , Liu Mingchuan , Hu Lang , Guo Dong , Wang Di , Qi Bingchao , Ren Gaotong , Hu Chenchen , Zhang Feng , Chun Hyung J. , Song Liqiang , Hu Jianqiang , Li Yan
Published: August 2022

Background
Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear. This study aimed to investigate the role of the long non-coding RNA (LncRNA) Airn in the pathogenesis of cardiac fibrosis in diabetic cardiomyopathy (DCM) and its underlying mechanism.
Methods
Diabetes mellitus (DM) was induced in mice by streptozotocin injection. An intramyocardial adeno-associated virus (AAV) was used to manipulate Airn expression. The functional significance and underlying mechanisms in DCM fibrosis were investigated both in vitro and in vivo.
Results
Diabetic hearts showed a significant impairment in cardiac function, accompanied by obviously increased cardiac fibrosis. Interestingly, lncRNA Airn expression was significantly decreased in both diabetic hearts and high glucose (HG)-treated cardiac fibroblasts (CFs). AAV-mediated Airn reconstitution prevented cardiac fibrosis and the development of DCM, while Airn knockdown induced cardiac fibrosis phenotyping DCM. As in vitro, Airn reversed HG-induced fibroblast-myofibroblast transition, aberrant CFs proliferation and section of collagen I. In contrast, Airn knockdown mimicked a HG-induced CFs phenotype. Mechanistically, we identified that Airn exerts anti-fibrotic effects by directly binding to insulin-like growth factor 2 mRNA-binding protein 2 (IMP2) and further prevents its ubiquitination-dependent degradation. Moreover, we revealed that Airn/IMP2 protected p53 mRNA from degradation in m6A manner, leading to CF cell cycle arrest and reduced cardiac fibrosis. As a result, ablation of p53 blunted the inhibitory effects of Airn on fibroblast activation and cardiac fibrosis.
Conclusions
Our study demonstrated for the first time that Airn prevented the development of cardiac fibrosis in diabetic heart via IMP2-p53 axis in an m6A dependent manner. LncRNA Airn could be a promising therapeutic target for cardiac fibrosis in DCM.
Adequate preoperative hemoglobin level in patients with thoracic and lumbar tuberculosis: A single center retrospective cohort study
Authors: Jiang Guanyin , Du Xing , Zhang Muzi , Qin Wanyuan , Xiong Tuotuo , Ou Yunsheng
Published: August 2022

Objective: This study aimed to find out the risk factors of postoperative moderate anemia (PMA) to develop a scoring scale for predicting the occurrence of PMA and to determine the recommended preoperative hemoglobin level in spinal tuberculosis (STB) patients.Methods: A total of 223 STB patients who underwent focus debridement from January 2012 to March 2020 were enrolled in the study. The study cohort was divided into two groups owing to the occurrence of PMA. Moderate anemia was defined as a hemoglobin level of < 90 g/L. The clinical characteristics of STB patients who developed PMA were evaluated, and a scale was developed by logistic regression analysis. The performance of this scoring scale is prevalidated.Results: Of the 223 patients, 76 developed PMA. Multivariate binary logistic regression analysis showed that body mass index, diabetes, low preoperative hemoglobin level, long operation time, and posterior approach were independent risk factors for PMA in STB patients. These significant items were assigned scores to create a scoring scale as to predicting PMA, and receiver operating characteristic (ROC) curve analysis implicated that the optimal cutoff score was 4 points. On the basis of the scoring scale, patients with scores within 0–3 points were defined as the low-risk group; those with scores within 4–6 points were defined as the moderate-risk group; and those with scores within 7–10 points were defined as the high-risk group. The perioperative decrease in hemoglobin level was 20.07 ± 10.47 g/L in the low-risk group, 24.44 ± 12.67 g/L in the moderate-risk group, and 29.18 ± 10.34 g/L in the high-risk group.Conclusion: According to the scoring scale, patients with STB with a score of 0–3 points have a low risk of PMA, those with a score of 4–6 have a moderate risk, and those with a score of 7–10 have a high risk. The recommended preoperative hemoglobin levels for the low-, moderate-, and high-risk groups are 110, 115, and 120 g/L, respectively.
Comparison of the performance of decision tree types in determining the most important factors associated with the death of patients with Covid-19 hospitalized
Authors: Karimzadeh Mohammad , Eshrati Babak , Ghaderi Ebrahim , Nouri Bijan , Aghaei Abbas
Published: August 2022

BackgroundNumerous factors are associated with mortality of people with COVID-19. This study aimed to investigate the most important of these factors related to the death of hospitalized patients with COVID-19 using decision tree algorithms.MethodsThe study data included the information of 8295 patients admitted to the hospitals of Iran University of Medical Sciences, who definitely had COVID-19. After cleaning the data, the most important factors related to the death of patients with COVID-19 were examined based on the indicators of sensitivity, specificity, accuracy and the area under the ROC curve (AUC) using decision tree algorithms (CHAID, C5.0, Random Tree, QUEST, and CART) with a ratio of 70% training and 30% testing. Analyzes were performed using IBM SPSS Modeler software version 18.ResultsAnalysis of the study results based on the testing data showed in terms of the area under the ROC curve (AUC), CHAID algorithm with 99.4%, in terms of sensitivity, CART algorithm with 99.5%, in terms of specificity, CHAID algorithm with 87.3%, in terms of accuracy, CHAID algorithm with 97.7% and finally in terms of the positive predictive value, CHAID algorithm with 98% had the best performance.Also, the most important factors affecting death (four main factors) were isolation, hospitalization in the ICU, and age, respectively, according to CHAID algorithm; age, symptoms up to hospitalization, occupation, and isolation, respectively, in RF algorithm; isolation, age, diarrhea, and the province of residence, respectively, in C5.0 algorithm; hospitalization in the ICU, age, isolation and dyspnea, respectively, in QUEST algorithm; and hospitalization in the ICU, treatment protocols, age and isolation, respectively, in CART algorithm. According to these results, the best performance was related to the CHAID algorithm.ConclusionDecision tree algorithms, especially CHAID algorithm, showed good performance in determining factors related to death of patients hospitalized due to COVID-19. Accordingly, isolation, hospitalization in the ICU, age and underlying diseases such as cardiovascular diseases and diabetes were the most important factors associated with death of these people.
Assessment of dams’ efficiency under the effect of climate change and urban expansion: Brayman Dam (Case Study)
Authors: Saeed Emaad , Al-Amir Nassir , Elfeki Amro
Published: August 2022

This paper analyzes the effect of climate change and urbanization on the efficiency of dams that have been built to protect Jeddah city in Saudi Arabia from severe floods. Brayman dam is considered a case study. Several data have been collected to address the objectives. Among these data are the historical rainfall, digital elevation models, a base map of Jeddah city, and its future expansion up to 2050. Hydrological analyses have been performed using common software: HEC-HMS, GIS, and WMS software to estimate the floods under the normal (design) conditions, the effect of climate change, and urbanization. It has been shown that under the normal condition (NC) scenario, the Brayman dam capacity can accommodate the floods for up to 200 years return period. The effect of the climate change scenario (CC) is more significant than the effect of the urbanization scenario (U). The effect of urbanization scenario (U) leads to shortening the time to peak of the flood. In the combined scenarios (CC + U), the runoff volume exceeded the dam capacity by about 66% and the dam is expected to get overtopped by 26% from the current dam height, and the dam lake is expected to inundate 46% more area than the current condition.
Cyclodextrin carboxylate improves the stability and activity of nisin in a wider range of application conditions
Authors: Jin Zhengyu , Hu Yao , Xing Kequan , Qiu Chao , Li Xiaojing , Sang Shangyuan , McClements David , Chen Long , Long Jie , Jiao Aiquan , Xu Xueming , Wang Jinpeng
Published: August 2022

Nisin is a natural bacteriocin that is claimed to exhibit good antibacterial activity against Gram-positive bacteria. It has good solubility, stability, and activity under acidic conditions, but it becomes less soluble, stable, and active when the solution pH exceeds 6.0. In this study, we investigated the potential of complexing nisin with a cyclodextrin carboxylate, succinic acid-β-cyclodextrin (SACD), to overcome the disadvantages. Strong hydrogen bonding was shown between the nisin and SACD, promoting the formation of nisin-SACD complexes. These complexes exhibited good solubility under neutral and alkaline conditions, and good stability after being held at high pH values during processing with high-steam sterilization. Moreover, the nisin-SACD complexes displayed significantly improved antibacterial activity against model Gram-positive bacteria (S. aureus). This study shows that complexation can improve the efficacy of nisin under neutral and alkaline situations, which may greatly broaden its application range in the food, medical, and other industries.
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome
Authors: Zheng Xue , Gong Taowu , Tang Chunchun , Zhong Yuanping , Shi Lu , Fang Xu , Chen Dongqin , Zhu Zhaoqiong
Published: August 2022

Neuroinflammation is the main pathological mechanism of cognitive dysfunction caused by neurodegenerative diseases, and effective preventive and therapeutic measures are not available. We predicted the key targets of gastrodin's effects upon neuroinflammation through Network Pharmacology and molecular docking. Then the predicted targets were used to study how gastrodin affected cognitive dysfunction triggered by lipopolysaccharide-induced neuroinflammation in rats and its mechanisms. Three-month-old male rats were intraperitoneally injected with lipopolysaccharide for 3 days (d), 7 d and 14 d respectively. Gastrodin improved learning and memory ability of rats with neuroinflammation. Lipopolysaccharide enhanced the levels of pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6, in rat hippocampus, which could be reversed by gastrodin. Gastrodin also inhibited the activation of microglia. Our findings suggested that gastrodin exerted neuroprotective effects in rats with neuroinflammation by impacting the TLR4-NF-kB-NLRP3 pathway. Therefore, gastrodin may be a potential therapeutic agent for neuroinflammation-induced cognitive dysfunction.
Epigenetic encoding of T cell dysfunction is enacted within hours of tumor antigen encounter prior to cell division
Authors: Philip Mary , Rudloff Michael , Zumbo Paul , Favret Natalie , Roetman Jessica , Roman Carlos Detres , Erwin Megan , Jonnakuti Sriya , Dündar Friederike , Betel Doron
Published: August 2022

Tumor-specific CD8 T cells (TST) found in patients with cancer are unable to halt cancer progression. TST are dysfunctional and cannot produce effector cytokines or kill target cells1. TST dysfunction, also known as exhaustion, has been thought to be driven by chronic T cell receptor (TCR)/antigen stimulation over days to weeks, encoded by exhaustion/dysfunction-associated epigenetic and transcriptional programs1,2. However, we know little about (i) the interplay between CD8 T cell function and epigenetics during the initial hours after activation in both functional (acute infection) or dysfunctional contexts (tumors) or (ii) the kinetics of CD8 T cell effector or dysfunction differentiation and relationship to cell division. Nevertheless, is it widely thought that T cell effector differentiation requires cell division3. Here we tracked differentiation of naive antigen-specific CD8 T cells by cell division within the first hours (0-60 hours) after antigen activation in tumor-bearing hosts, comparing to T cells undergoing functional effector differentiation during acute infection (E). Surprisingly, while TST and E exhibited the same rapid activation and cell division kinetics, TST failed to acquire effector function and implemented exhaustion-associated chromatin features. Notably, epigenetic encoding of TST dysfunction began within 6 hours of antigen encounter, even prior to cell division. These findings not only challenge the paradigm that chronic T cell receptor stimulation drives dysfunction/exhaustion in tumors, but also refute for CD8 T cells the prevailing notion that cell division is required to initiate epigenetic remodeling and differentiation3-7. Interestingly, while T cell dysfunctional fate decisions are made within hours of antigen encounter, continued TCR stimulation and epigenetic remodeling progressively stabilize, or “imprint” the dysfunctional state. Our study defines for the first time the regulation and kinetics driving the rapid divergence of T cell fate choice prior to cell division in the context of tumors versus infection.
Safety profile of Colocasia esculenta tuber extracts in benign prostate hyperplasia
Authors: Tusubira Deusdedit , Aja Patrick M. , Munezero Jonasi , Ssedyabane Frank , Namale Nathim , Ifie Josiah . E. , Agu Peter C , Ajayi Clement O. , Okoboi Joash
Published: August 2022

Introduction: This study was motivated by the increasing global incidence of benign prostatic hyperplasia (BPH) and the promising potential of nutraceuticals as complementary therapies in ameliorating its burden. We report the safety profile ofColocasia esculentatuber extracts, a novel nutraceutical in benign prostate hyperplasia in a rat model.Methods: In our study, forty-five male albino rats were randomly assigned into 9 groups of 5 rats each. Group 1 (normal control) received olive oil and normal saline. Group 2 (negative control) received 3 mg/kg of testosterone propionate (TP) and normal saline, group 3 (positive control) received 3mg/kg of TP and 5 mg/kg of finasteride. Our treatments groups 4, 5, 6, 7, 8 and 9 received 3 mg/kg of TP and lower dose (100 mg/kg) of LD50of ethanol crude tuber extract ofColocasia esculenta(ECTECE) or hexane, dichloromethane, butanone, ethylacetate and aqueous fractions of ECTECE respectively for a period of 28 days.Results: The negative controls showed significant (p < 0.05) increase in mean prostate weight (approximately 5 times) as well as reduction in relative testes weight (approximately 1.4 time less). There was no significant (p > 0.05) difference in mean relative weights of most vital organs: liver, kidneys and heart. This was also observed in hematological parameters: RBC, hemoglobin, HCT, MCV, MCH, MCHC and platelets counts. In general, we note that the effects of the well-established drug finasteride on the biochemical parameters and histology of selected organs are comparable to those of c.esculentafractions. Conclusion: This study demonstrates safety potential ofC. esculentatuber extract in a rat model.