bluuebunny/crossref_metadata_2025 huggingface dataset:
CIBERESPAÇO E A CULTURA CONTEMPORÂNEA
Authors: Pelozato Jaqueline
Published: February 2022

Em uma pesquisa realizada para a escrita de nossa dissertação de mestrado, apostamos na ideia de que é possível promover a ampliação da concepção de cidadania nas redes sociais, mediante a produção de pautas que amplificassem as vozes dos movimentos sociais, num momento em que novas narrativas estão se constituindo nas redes sociais, tendo os jovens como os protagonistas que estão ressignificando esse espaço, reelaborando sua subjetividade por meio dessas novas formas de sociabilidade e interação. O artigo ora apresentado é parte deste esforço maior, mas, aqui, nosso objetivo é apresentar o conceito de ciberespaço como um elemento da cultura contemporânea, revelador de novas relações sociais para em seguida propor a visualização de novas narrativas históricas. É, por meio de uma potencial associação entre ensino de História e as novas tecnologias digitais ligadas à cibercultura que salientamos para a importância História Pública.
UMA DISCUSSÃO ACERCA DA INFLUÊNCIA DO ASPECTO ECONÔMICO NA DESVINCULAÇÃO DA MULHER EM SITUAÇÃO DE VIOLÊNCIA DOMÉSTICA DO AGRESSOR
Authors: Tanski Daiane , Neubauer Vanessa Steigleder , Silva Luiza Heider Salles da , Fernandes Angélica da Silva
Published: February 2022

A pesquisa tem por objetivo analisar o Projeto de Lei nº 3.974/2020 que visa criar o selo, “Empresa parceira na luta ao enfrentamento à violência doméstica” e o Projeto de Lei nº 323/2021 que tem como objetivo incluir a mulher vítima de violência doméstica nos programas de geração de renda gerenciados ou financiados pelo governo federal. Para tanto faz-se necessário ponderar a violência doméstica contra a mulher, além da dificuldade de desvinculação do agressor acerca da dependência econômica. A pesquisa é cunho bibliográfica, de natureza qualitativa, permeando uma investigação doutrinária, jurisprudencial e literária acerca da temática. Para melhor esclarecer os propósitos deste estudo ele divide os resultados e discussões em três momentos, a violência doméstica contra a mulher no Brasil, as reflexões históricas acerca do mercado de trabalho para a mulher e, por fim o e terceiro momento, a dificuldade da desvinculação da mulher em situação de violência doméstica do agressor diante da questão econômica.
Development and Validation of Questionnaire for Physics Learning Self-Efficacy among Ghanaian Senior High Schools
Authors: Appiah-Twumasi Eric , Ameyaw Yaw , Kwasi Anderson Ishmeal
Published: February 2022

This study focused on developing an instrument for assessing Senior High School students Physics learning self-efficacy beliefs. An instrument known as PLSE was administered on-site and in-person. The PLSE was tested on 290 final year Senior High School Physics students. Prior to this, the initial scale was administered to 60 Senior High School Physics students after validation by seven experts of Science educators. The PCA extracted four factors with loadings ranging from 0.588 to 0.889. The four factors were Physics Practical, Every Application of concepts, High-Order Thinking Skills and Physics Content. The calculated Average Variance Extracted (AVE), and Composite Reliability of the PLSE items were also found to range from 0.540 to 0.718 and 0.823 to 0.927 respectively. The subsequent reliability results showed excellent internal reliability for each of the sub-scales with Corrected Item-total Correlation (CIC) values, ranging between 0.571 and 0.752. Validity, and reliability assessments revealed accepted threshold cut-off of Average Variance Extracted (AVE), Composite Reliability (CR,) and Cronbach's Alpha coefficient. This paper suggests that the current proposed Physics learning instrument represent a reliable research scale to measure Senior High students Physics learning self-efficacy belief.
A Study on Impact of Social Media on Consumer Buying Behavior
Authors: Sumathi M. , C. Bavatharani , S. Bavitha , R. BrindhaSri , A. Elanthendral , T. Vyshali
Published: February 2022

Online activity in consumer’s behavior is gradually growing at a very fast rate with the tremendous involvement in social media and user created content on sites, like Face book, blogs, YouTube, LinkedIn, etc. In businesses, social media is generally used to spread the awareness about the products and services, promoting brands, to retain the existing customers and to find new prospects. Social media provide better relationship with the customers for the business.
A Study on Public Acceptance, Awareness Attitude towards Covid Vaccines with Special Reference to Coimbatore City
Authors: Begum A. Anitha , Jannani M. , Jacob Netra Rebecca , Fatima P. Shameem , Subashini R. , Kowshika N.
Published: February 2022

Vaccines are an effective method that can reduce the impact of diseases. However public vaccines hesitancy is a major problem. With the availability of covid 19 vaccines limited information is available on the acceptance, awareness and attitude towards covid vaccines. This study aims to assess the public acceptance, awareness and attitude towards covid vaccines.
A Study on Consumers’ Intention and Buying Behaviour towards the Purchase of Electric Vehicles with Special Reference to Coimbatore City
Authors: Begum A. Anitha , S. S. Abinaya , G. Chitrakala , Shree L. Divya , M. Raghavi , S. Savivarsha , S. Savivarsha , S. Savivarsha , S. Savivarsha , S. Savivarsha , S. Savivarsha , S. Savivarsha
Published: February 2022

Electric Vehicles are advanced technology for success in tenable transport sector in the future due to the cost effective low maintenance, Easy driving.This paper present briefly some exposure of Electric Vehicle including its Industries consumer perceptions and adaptation of Electric Vehicle behaviour, attitudes towards Electric Vehicle, environment benefit of Electric Vehicle, and its battery life. The government has to take initial measures to develop the usage of Electric Vehicle among consumer and the price of Electric Vehicles should be affordable by the consumers. The automobile industries have to develop the Electric Vehicle production.
Working Capital Management Practices of Telecom Companies in India
Authors: Karthika A. , C. D. Kanisha , R. Koushika , G. B. Malashree , K. Sowmya , M. Srinidhi
Published: February 2022

The Telecom industry in India is the second biggest in the planet with a subscriber base of 1.17 billion. In February 2021, the number of broadband -subscribers rose to 765.1 million. The Government has emphasized reinforcing India’s domestic telecom manufacturing capacity. Efforts are additionally in progress to create a foundational network for 5G technology deployment in India. Working capital is the existence blood and operational hub of a business, which is exceptionally fundamental to keep up with the smooth running of business. Working Capital Administration is a significant part for each organization and firm. Its impact on profitability of 10 Indian Telecom companies listed in the National Stock Exchange for a period of five years from 2017 to 2021 are analysed.
Hipoacusia sensorineural asimétrica en el diagnóstico de schwannoma vestibular
Authors: Coutinho de Toledo Heloisa , Celis-Aguilar Erika
Published: February 2022

Introducción: se ha descrito que los pacientes con hipoacusia asimétrica cursan en un 2% con lesiones retrococleares. La conducta de escrutinio se ha basado en la audiometría. Existen varias definiciones de asimetría audiométrica descritas en la literatura, pero sin llegar a un consenso. Aunque la prueba de oro para el diagnóstico de schwannoma vestibular es la resonancia magnética con gadolíneo, la sospecha clínica se hace en base a la asimetría audiométrica.
Objetivo: hacemos una revisión de los trabajos publicados al respecto en la literatura y comentamos nuestra experiencia.
Reflexión: queremos enfatizar en la importancia de estudiar a los pacientes con hipoacusia asimétrica con el fin de descartar patología retrococlear.
Conclusión: a pesar de que no existe un consenso claro en la definición de hipoacusia asimétrica, la sospecha clínica de un schwannoma vestibular se basa en la audiometría.
Efecto inmediato de dos ejercicios con tracto vocal semiocluido en el contacto glótico de usuarios ocupacionales de la voz
Authors: Delprado-Aguirre Fernando , Ángel Gordillo Luisa Fernanda , Calvache-Mora Carlos Alberto
Published: February 2022

Introducción. Los docentes son usuarios ocupacionales de la voz con alto riesgo de desarrollar patologías vocales a causa de su labor. Para enfrentar esta problemática, suelen usarse ejercicios con tracto vocal semiocluido (TVSO), estrategia de educación/rehabilitación empleada para generar un cambio en el patrón de vibración de los pliegues vocales, minimizando el riesgo de lesión vocal al reducir el estrés de colisión al que se someten los tejidos. Diversos reportes han indicado que este tratamiento tiene efectos en el cociente de cierre (CQ), medida indirecta del estrés de colisión.
Objetivo. Examinar el efecto fisiológico de dos ejercicios con TVSO en la actividad laríngea de profesores con esfuerzo vocal constante pero sin patología vocal.
Metodología. Se registraron muestras de 43 profesores antes, durante y después de la realización de dos ejercicios con TVSO (vibración lingual y fonación en tubos). Las muestras de electroglotografía se analizaron para obtener el CQ.
Resultados y conclusión. Se observó una diferencia significativa al comparar los valores del CQ antes y durante la realización de ambos ejercicios. No se encontraron cambios en este parámetro después de ejecutar la actividad. Estos hallazgos concuerdan con reportes previos en los cuales el CQ tiende a aumentar durante la fonación en tubos; contrariamente, la realización de la vibración lingual tiende a decrecer el valor del CQ. Es posible que este comportamiento se deba a los mecanismos biomecánicos particulares de cada ejercicio.
Rehabilitación neuropsicológica en pacientes pre y posquirúrgicos de lobectomía temporal por epilepsia fármaco resistente
Authors: Múnera Rodríguez Yeiran Camilo , Arias-Ramírez Yaira Zuleine
Published: February 2022

Introducción. La epilepsia del lóbulo temporal suele producir déficits mnésicos, atencionales y del lenguaje. En la mayoría de los casos, se trata con fármacos antiepilépticos, pero falla en un tercio de ellos. Por tal razón una opción terapéutica es la lobectomía temporal, que contribuye a menguar las crisis. Sin embargo, los procedimientos quirúrgicos pueden conllevar secuelas, entre ellas consecuencias a nivel cognitivo. Para contrarrestar dichos efectos, se acostumbra llevar a cabo una rehabilitación neuropsicológica que va en pro de recuperar, fortalecer y sostener en el tiempo habilidades que ya venían afectándose desde antes de la cirugía. Objetivo. Brindar una reflexión en torno a la intervención neuropsicológica de la epilepsia en el lóbulo temporal. Método. La reflexión sobre el tema parte de un interés clínico y posteriormente se fue ampliando a partir de la revisión de la literatura en diferentes bases de datos como PubMed, Medline y Scopus entre los años 2000 y 2021. Reflexión. Son amplias las opciones terapéuticas a nivel neuropsicológico y pueden contribuir de manera positiva en la recuperación del paciente, por lo cual los profesionales requieren conocer las posibilidades de ello para poder utilizar las estrategias más adecuadas según cada caso y brindar opciones que beneficien la calidad de vida, teniendo en cuenta que ninguna es más efectiva que otra. Conclusión. Como resultado, se presenta un panorama general de la rehabilitación neuropsicológica en pacientes pre y posquirúrgicos con lobectomía, haciendo énfasis en la rehabilitación neuropsicológica tradicional y la rehabilitación basada en inteligencia artificial, realidad virtual y computación.
SCRUB TYPHUS PRESENTING AS ACUTE PANCREATITIS: A RARE CASE
Authors: Kumar Amsa Palanikumar Goutham , Kanna Subramaniam Suresh , Babu Dinesh
Published: February 2022

Scrub typhus is an insect-borne disease caused by Orientia sutsugamushi which may cause disseminated vasculitis and perivascular inflammatory lesions resulting in significant vascular leakage and cause end organ damage. Scrub typhus can lead to severe complications such as acute respiratory distress syndrome (ARDS), myocarditis, hepatitis and meningoencephalitis. Some unusual presentations of scrub typhus are peritonitis, gastric ulceration, duodenal ulcer perforation and acalculous cholecystitis. But acute pancreatitis is a relatively rare complication of scrub typhus. Here we report a rare case of scrub typhus in the form of acute pancreatitis.
PLACENTAL DIAMETER AND THICKNESS AND NUMBER OF COTYLEDONS IN MILD AND SEVERE PREGNANCY INDUCED HYPERTENSIVE WOMEN VERSUS NORMOTENSIVE WOMEN OF DISTRICT D.I.KHAN, PAKISTAN
Authors: Aman Shehla , Arif Sarah , Amanullah Amir , Khan Jamshed , Yunus Sarah , Ullah Usman
Published: February 2022

Background: Pregnancy induced hypertension (PIH) adversely affects the development of placenta and growth of fetus. The objectives of this study were to compare the placental diameter, placental thickness and number of cotyledons in mild PIH and severe PIH women versus normotensive women of District D.I.Khan, Pakistan.Material Methods: This comparative cross-sectional study was conducted in Department of Anatomy, Gomal Medical College, D.I.Khan, Pakistan from January to October 2014. Three samples were selected; each of size 50, group 1 normotensive/ control, group 2 with mild PIH and group 3 with severe PIH. Three research variables; placental diameter (cm), thickness (mm) and number of cotyledons were measured on ratio scale for three groups. Descriptive analysis included mean± SD with 95% confidence intervals for each group separately. With three groups on ratio data, one way-ANOVA test was applied to see significance of difference between three groups. Post hoc Dunnett’s t test was applied at alpha 0.05 to see difference of mild PIH group 2 to normotensive/ control group 1 and of severe PIH group 3 to normotensive/ control group 1separately.Results: Mean placental diameter was 18.28±2.15, 16.57±1.94 and 16.18±1.75 cm and mean placental thickness was 19.33 ±3.70, 19.18±2.78 and 17.60±3.52 mm in group 1, 2 and 3 respectively. Mean number of cotyledons was 14.42±2.25, 14.08±2.30 and 13.16±2.15 in group 1, 2, and 3 respectively. Placental diameter was statistically significantly lower in group 2 (p=.00001) and 3 (p=.00001) than group 1. Placental thickness in group 2 (p=.957) was similar to group 1, while in group 3 (p=.019) it was lower than group 1. Number of cotyledons in group 2 (p=.666) was similar to group 1, while in group 3 (p=.011) it was lower than group 1.Conclusion: In mild pregnancy induced hypertension (PIH), placental diameter was lower than normotensives, while placental thickness and number of cotyledons were similar to normotensives. In severe PIH, placental diameter, placental thickness and number of cotyledons were all lower than normotensives. It is concluded that in mild PIH, the development of placenta is mildly affected, while in severe PIH, the development of placenta is severely affected.
DISTRIBUTION OF HEPATITIS B INFECTED POPULATION BY SEX AND AGE GROUPS IN DISTRICT D.I.KHAN, PAKISTAN
Authors: Ullah Imran , Khan Nisar , Shah Farmanullah , Ahmad Ejaz , Saeed Asif
Published: February 2022

Background: Significant morbidity and mortality is caused by untreated hepatitis B virus infection through cirrhosis and hepatocellular carcinoma. The objectives of our study were to determine distribution of hepatitis B infected population by sex and age groups in District D.I.Khan, Pakistan.Materials Methods: This cross-sectional study was done at District Health Office, D.I.Khan, Pakistan from January 30, 2021 to February 15, 2021. Data was collected for period from March 14, 2013 to January 28, 2021 for 2368 hepatitis B infected cases from population at risk consecutively. Sex and age groups were demographic variables. Data type was nominal for sex and ordinal for age groups. Distribution was analyzed by count, percentage and confidence intervals for proportion for population. Hypotheses for distribution were substantiated by chi-square goodness-of-fit test.Results: Out of 2368 hepatitis B infected population, 1670 (70.52%) were men 698(29.48%) women, and 562 (23.73%) were in age group 0-20 years, 1266 (53.46%) in 21-40 years, 462 (19.51%) in 41-60 years 78 (3.30%) in 60 years. Our distribution by sex (p.00001) and age groups (p.00001) were different than expected respectively.Conclusion: In our study, hepatitis B infection was more common in men than women and most common in age group 21-40 years, followed by 0-20 years, 41-60 years and 60 years. Our observed prevalence of hepatitis B infection in men was higher than expected in women it was lower than expected. Our observed prevalence in the four age groups was not similar to expected.
POST-OPERATIVE ORAL ANTIBIOTICS IN REDUCING FREQUENCY OF SURGICAL SITE INFECTION FOLLOWING NON-PERFORATED APPENDECTOMY IN POPULATION OF SOUTH WAZIRISTAN AGENCY, PAKISTAN
Authors: Alam Aftab , Rehman Aziz Ur , Waheed Dastageer , Khan Muhammad Hamayun , Ahmad Waseem , Bashir Irum
Published: February 2022

Background: Acute appendicitis is most frequent cause of acute abdomen in younger population, and surgical site infection (SSI) is commonest complication of appendectomy. The objective of this trial was to compare the efficacy of post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.Materials Methods: The randomized placebo trial was conducted at Agency Headquarter Hospital, Wana, South Waziristan, Pakistan from October 1, 2016 to November 18, 2018. One hundred fifty (150) patients were randomly allocated into two groups, 75 in experimental group, to whom antibiotics were given and 75 in placebo group, to whom antibiotics were not given. Age groups and presence of SSI were two variables, being on nominal scale, were described by count and percentage with CI at 80%CL. McNemar chi-square test was applied to test the hypothesis to see the significance of difference between the experimental and placebo groups in terms of frequency of SSI at alpha .05.Results: SSI was present in nine (12%, 80%CI 7.19-16.80%) out of 75 cases in experimental group and in 12 (16%, 80%CI 10.57-21.42%) out of 75 cases in placebo group. McNemar chi-square test showed no significant difference between the experimental and placebo groups in terms of frequency of SSI (p=.2482).Conclusion: The results are comparable for post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.
ADDRESSING MYTHS OF OUR MEDICAL COMMUNITY REGARDING RESEARCH
Authors: Ahmad Iftikhar
Published: February 2022

Writing the first research article is always considered a difficult task. With experience, the difficulty level decreases but still it’s not less than a nightmare for most of our medical community. Faculty, consultants and students are generally found struggling with their research projects. They are engaged in research, including basic science research, public health/ social science research, medical education research or clinical research. Research is conducted for one or more of the three reasons including identifying magnitude of the problem, cause of the problem or actual solution of the problem.
FUNGAL NEUROLOGICAL SEQUELAE IN A HYPER IMMUNOGLOBULIN E SYNDROME FROM PESHAWAR, PAKISTAN: AN UNUSUAL PRESENTATION
Authors: Ijaz Nadeem , Hanif Huma , Rehman Imtiaz Ur , Khan Sohail Daud , Khan Osama Sherjeel
Published: February 2022

Hyper IGE syndrome is one of the primary immunodeficiency syndromes characterized by the presence of abnormally raised serum IGE levels (2000 IU/ml) with defective humoral and cell mediated immunity presenting in infancy or early childhood. It is a rare disease with only about 200 cases reported in literature. Usually, it is diagnosed clinically and by raised serum IGE levels. Mostly, it presents with recurrent staphylococcal skin abscesses, sinopulmonary infections, and opportunistic mycotic infections due to the immunodeficient state. Rarely, the central nervous system is involved by this condition.This case study deals with an 11-year-old girl who was diagnosed as a case of hyper IGE syndrome. She presented with low GCS and focal neurological deficits which were attributed to aspergillus fumigatus infection spreading to the brain resulting in multiple abscesses and eventually to death of the patient despite treatment interventions. This case emphasizes the likelihood of dissemination of fungal infections to multiple organs including the brain and the potential role of early neuroimaging to detect such lesions. Moreover, it shows significance of serial imaging in admitted patients particularly with the onset of new and unusual neurological symptoms. With more extensive studies, we may be able to diagnose and treat such infections and their complications on time with better outcomes.
ARE ENZYME REPLACEMENT THERAPIES EFFECTIVE AGAINST LYSOSOMAL STORAGE DISORDERS?
Authors: Hassan Taimoor , Huadong Xu
Published: February 2022

Lysosomal storage disorders are an agglomeration of genetic disorders such as Fabry disease, Gaucher disease, Pompe disease, Krabbe’s disease and mucopolysaccharidosis that typically impairs the prime orangs of humans, including brain, heart, musculoskeletal system, spleen, eye, and lungs. Patients with lysosomal storage disorders face mild to severe complications and even death. In order to address these health concerns, scientists are working by dint off, various therapies are introduced such as gene therapy, typical oral medicines, organ/ cell transplantation etc. However, hematopoietic stem cell transplantation and enzyme replacement therapy came out as best stakeholders to treat aforementioned disorders. Nonetheless, according to suggested data, it is concluded that presently enzyme replacement therapies are somehow ineffective for many lysosomal storage disorders till today. But we believe that in near future, as more and more research will be progressed, the ultimate therapy to these disorders will be developed.
HOW STEM CELLS ARE SHAPING OUR DRUG DISCOVERY TECHNIQUES?
Authors: Hassan Taimoor
Published: February 2022

Stem cell biology is a fast-developing field of research that has made significant contributions to a wide range of scientific specialties, from developmental biology to regenerative medicine. One of the most promising implications of stem cell biology in recent years has been drug development. Stem cells are rapidly being employed in novel ways to enhance the drug development processes with applications ranging from academia to biotech start-ups to big pharmaceutical businesses.
PREVALENCE OF MORTALITY AND ITS DISTRIBUTION BY SEX AND AGE GROUPS IN INDOOR COVID-19 PATIENTS IN D.I.KHAN DIVISION, PAKISTAN
Authors: Aamir Muhammad , Ahmad Waleed , Ahmad Bashir , Khan Abdurrehman , Fawad Muhammad , Abdullah Muhammad
Published: February 2022

Background: COVID-19 has become one of the leading causes of morbidity and mortality. The objectives of this study were to determine the prevalence of mortality and its distribution by sex and age groups in indoor COVID-19 patients in D.I.Khan Division, Pakistan.Materials Methods: This cross-sectional study was conducted in the Department of Medicine, Gomal Medical College, D.I.Khan, Pakistan. A sample of 438 patients with positive SARS-CoV-2 RT-PCR was selected. Sex age-groups were two demographic and presence of mortality was a research variable. The data type for all variables was nominal, except ordinal age groups. Prevalence distribution were described by count and percentage with 95%CI. The hypotheses were tested by chi-square goodness of fit test.Results: Out of 438 COVID-19 patients, mortality was 43 (9.82%), including 34 (7.76%) men and nine (2.06%) women. The mortality was 0% for 0-19 years, four (0.92%) for 20-39 years, 12 (2.74%) for 40-59 years and 27 (6.16%) ≥60 years. Our mortality 9.82% was lower than expected 20.95% (p=.001). It was higher in men than women (p=.001). It was highest in age group ≥60 years, while 0% in 0-19 years. It was similar to expected by sex (p=.070) and age group (p=.207).Conclusion: Our study showed 9.82% mortality in indoor COVID-19 patients. The mortality was lower than expected. The mortality was higher in men than women. It was highest in elderly, while zero in children and adolescents. It was similar to expected by sex and age group.
COMPLICATIONS IN ABO-INCOMPATIBLE HEMATOPOIETIC STEM CELL TRANSPLANT IN PAKISTAN
Authors: Hussain Mussawair , Ullah Imran , Shahbaz Nighat , Chaudhry Qamar Un Nisa , Khan Mehreen Ali , Khattak Tariq Azam
Published: February 2022

Background: Hematopoietic stem cell transplantation (HSCT) is therapeutic option for many blood diseases. It has increased risk of complications with incompatible pair. The objective of this study was to determine the frequency of complications in ABO-incompatible HSCT in Pakistan.Materials Methods: This cross-sectional study was conducted at Armed Forces Bone Marrow Transplant Centre , Rawalpindi, Pakistan from 11th August 2018 till 15th March 2021. A sample of 73 ABO-incompatible HSCT patients was selected. Variables were sex, age groups, acute delayed hemolysis, pure red cell aplasia and acute GvHD. All variables being categorical were described by count and percentage with 80%CI. Complications in sample vs. population were compared through chi-square goodness of fit test.RESULTS: Seventy three patients with ABO-incompatible HSCT included 52 (71.23%) men 21 (28.77%) women, and 49 (67.12%) in age group ≤14 years 24 (32.88%) in ≥15 years. Out of 73 patients, eight (10.96%) had acute hemolysis, 26 (35.62%) had delayed hemolysis, four (5.84%) had pure red cell aplasia and 34 (46.58%) had acute GvHD. The observed prevalence in sample was similar to population for acute (p=.46893) and delayed hemolysis (p=.30759) and acute GvHD (p=.55841), while it was different for pure red cell aplasia (p=.00006).CONCLUSION: Most common complication in our study was acute GvHD, followed by delayed hemolysis, acute hemolysis pure red cell aplasia. The observed prevalence in sample was similar to population for acute delayed hemolysis and acute GvHD, while it was different for pure red cell aplasia.
INTENSIVE CARE UNIT MANAGEMENT OF SARS-COV-2 PATIENTS: A NARRATIVE REVIEW
Authors: Hassan Taimoor , Saeed Sana , Naseem Sidra , Saleem Fiza
Published: February 2022

The 2019 Coronavirus disease is a public health emergency of international concern (PHEIC). COVID-19 causes acute respiratory distress syndrome (ARDS) in certain individuals. In such individuals, non-invasive and invasive ventilation methods are used to treat acute respiratory distress syndrome. Non-invasive ventilation approaches must be used initially before introducing intrusive mechanical ventilation techniques. Non-invasive methods used in the therapy of COVID -19 associated acute respiratory syndrome include high-flow nasal cannula, bi-level positive air pressure (BiPAP), and helmet ventilation. Before employing any of these non-invasive methods, the risk of viral aerosol transmission to healthcare and paramedical personnel must be considered. When non-invasive procedures are used, the load on hospital ventilatory equipment can be reduced. If at all possible, avoid intubating the patient too soon. The clinical appearance of the patient, as well as vital indicators such as oxygen saturation and respiratory rate, must be evaluated on a frequent basis in order to determine whether the patient requires ventilation. In COVID-19 patients, the judicious application of non-invasive and invasive breathing methods can minimize the risk of death from acute respiratory distress syndrome.
EFFICACY OF ALFUZOSIN VERSUS CONTROL GROUP IN UPPER URETERIC STONE EXPULSION IN ADULT POPULATION OF LAHORE, PAKISTAN
Authors: Humayun Fawad , Mujtaba Ghulam , Seerwan Muhammad , Khan Ghazi , Javed Naseem , Adnan Muhammad
Published: February 2022

Background: Urinary stone disease is one of the commonest urological diseases worldwide. The objective of this study was to compare the efficacy of alfuzosin versus control group in upper ureteric stone expulsion in adult population of district Lahore, Pakistan.Materials Methods: This trial was conducted in Department of Urology, Sheikh Zayed Hospital, Lahore, Pakistan form January 2017 to June 2017. All adult patients with upper ureteric stone size 5-10 mm were eligible. Those with multiple stones, having fever, severe pain, history of surgery in past two weeks and growth on urine culture or pyuria were excluded. Experimental and control groups each had 30 patients. Experimental group received Tab. alfuzosin 10 mg daily for four weeks and Tab. diclofenac sodium 50 mg SOS for acute pain. The control group received Tab. diclofenac sodium 50 mg SOS for acute pain. We followed all patients for four weeks for expulsion of ureteric stones by X-ray KUB or CT KUB. Sex, age and stone size were matching variables. Stone expulsion (yes, no) was research variable. We compared count of stone expulsion between two groups by using McNemar chi-square test at alpha 0.5 using GraphPad.Results: Out of 30 patients in experimental group, 23 (76.67%) were men and seven (23.33%) women and out of 30 in control group, 20 (66.67%) were men and 10 (33.33%) women, almost similar in both groups. Mean age in experimental group was 39.45±10.33 years and in control group it was 37.38±8.28 years, almost similar in both groups. Mean stone size was 7.45±1.47 (5-10) mm in the experimental and 7.28±1.68 (5-10) mm in control group, being comparable in both the groups. In experimental group, stone expulsion was achieved in 23 (76.67%) cases and not in seven (23.33%) cases and in control group, it was achieved in 16 (53.33%) cases and not in 14 (46.67%) cases. There was statistically no significant difference in efficacy of alfuzosin versus control group (p=.1213).Conclusion: Our study showed no difference in efficacy of alfuzosin versus control group for upper ureteric stone expulsion in adult population of district Lahore, Pakistan.
SERUM LEVELS OF OXIDATIVE STRESS MARKERS IN SUBCLINICAL AND OVERT HYPOTHYROIDISM VERSUS CONTROL GROUP IN POPULATION OF KUTAHYA CITY, TURKEY
Authors: Yontem Mustafa , Arslan Serap , Erdogdu Behic Selman , Kocak Fatma Emel
Published: February 2022

Background: Overproduction of oxygen-related free radicals and inadequate antioxidant defense are critical in hypothyroidism, as they might lead to future life-threatening diseases. The objectives of this study were to compare serum levels of oxidative stress markers; total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and arylesterase (ARYL) in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) versus healthy controls in population of Kutahya city, Turkey.Materials Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey, from July to December, 2016. Three study groups of 45 each were formed as healthy controls, patients with SH and OH. Serum levels of TOS, TAS, OSI, PON-1, and ARYL were five research variables with ratio scale, but skewed, so described by median and IQR with 95% Cl. Kruskal-Wallis and multiple comparison tests were used for hypotheses testing.Results: Serum levels of TOS and OSI were higher in SH group (p-values 0.032; .0001; respectively) and OH group (p-values .0001; .0001, respectively) than healthy controls, while serum levels of TAS, PON-1 and ARYL were lower in SH group (p-values .0001; .0001; .0001, respectively) and OH group (p-values .0001; .0001; .0001, respectively) than control group.Conclusion: Our study showed that serum levels of TOS and OSI were higher in subclinical and overt hypothyroidism than in healthy controls; while serum levels of TAS, PON-1, and ARYL were lower in subclinical and overt hypothyroidism than in healthy controls.
EFFICACY OF DOXAZOSIN VERSUS TAMSULOSIN IN LOWER URETERIC STONE EXPULSION IN ADULT POPULATION OF DISTRICT DERA ISMAIL KHAN, PAKISTAN
Authors: Seerwan Muhammad , Khan Ghazi , Ilyas Muhammad , Waheed Dastgeer , Ur Rehman Atta , Humayun Fawad
Published: February 2022

Background: Urolithiasis is the third common disease of the urinary tract after UTIs and pathological diseases of the prostate. The objective of this study was to compare the efficacy of doxazosin versus tamsulosin in lower ureteric stone expulsion in adult population of District Dera Ismail Khan, Pakistan.Materials Methods: This non-randomized control trial was conducted in the Department of Urology, Gomal Medical College, Dera Ismail Khan, Pakistan from February 2020 to December 2020. The 252 patients included in our study were divided in to two groups. The patients in experimental group received Tab. doxazosin 4 mg daily for 4 weeks and Tab. diclofenac sodium 50 mg B.D for 5 days and then on need basis. The patients in control group received Cap. tamsulosin 0.4 mg daily for 4 weeks and similarly Tab. diclofenac sodium 50 mg as in experimental group. All the patients were followed regularly for expulsion of ureteric stones for four weeks. Sex, age and stone size were matching, while stone expulsion was a research variable. Hypothesis was verified by McNemar chi-square test.Results: Out of 252 patients, 113 (89.68%) patients in experimental group, while 77 (61.11%) patients in control group passed the stones. There was statistically significant difference in efficacy in doxazosin group as compared to tamsulosin group (p-value=.0001).Conclusion: The use of doxazosin as the medical expulsion therapy for the lower ureteric stone proved to be more effective as compared to tamsulosin as demonstrated by our results.
NEUROTRANSMITTERS FOR MATH BRAIN: A NEW FINDING
Authors: Hassan Taimoor
Published: February 2022

Neurotransmitters are the body's chemical transmitters. Their task is to send nerve cell messages to target cells. The target cells might be found in muscles, glands and other nerves. In order to control many of the processes needed for the brain, it needs neurotransmitters including: heart rate, respiration, circadian rhythms, digestion. The nervous system regulates the organs, psychological and physical operations of the individual. The neurotransmitters of nerve cells, also known as neurons, have a substantial function. The cells of the nerves fire impulses. This is done by the release of neurotransmitters, chemical substances that relay signals to other cells. Each neurotransmitter binds to another receptor — for instance, dopamine molecules attach to the receptors of dopamine. This initiates action in the target cells when they are coupled. The body eliminates or recycles them after neurotransmitters send their messages.
A Literary Review of Trunapanchamula w.s.r to Role in Stanya Janana
Authors: Balaji Thakur  , Mahendra Prasad  , C.R. Yadav  , Bhanu Pratap Singh
Published: February 2022

Breastfeeding is a hormonal, emotional physical and dietary phenomenon certain to be affected by every component. As Milk is a completely unique and whole nutritive supply for the mammal neonate, additionally imparting immune safety and developmental signals, it is the best way to care for new born. Besides creating the overwhelming bonding, it is also the perfect nourishment for them. In Ayurvedic texts, formation of Stanya (Breast milk), causes of Stanya pravriti (or milk ejection), Dhatri (wet-nurse), Dhatri-pariksha (examination of wet-nurse), Stanapan-vidhi (Breast feeding), Stanyasampat (merits of Breasts) etc. are described by different Acharyas Since try should be made to prevent it with right anticipation via multidimensional approach comprising of physical methods, provisions of nutritious lactogenic eating regimen and use of herbal galactagogues cited thoroughly in Ayurvedic literature. Synthetic Galactagogues cited in cutting-edge sciences pose a more chance of detrimental health dangers at the same time as Ayurveda manage protocol addresses internal balances and outdoor influences contributing to problem. Charaka also described Stanyajanana Mahakasaya likewise Susruta Vagabhatta described Gana in where Trunapanchamula is included in that. So, this review gives an integrated overview of the physiology of lactation with particular focus on physiology of milk production and secretion in respect to Ayurvedic and modern concept with special reference to Trunapanchamula.
Studies on Mutravaha Srotadusti W.S.R. to Lower Urinary Tract Infection
Authors: Sukalyan Ray  , Kaushik Porel
Published: February 2022

In Ayurveda, the term Srota has several meanings, but it primarily denotes channels or vessels or any hollow space. Although the total macro and micro channels within the human body are actually countless, thirteen important types of channels are described in all major compendiums. One such important channel is Mutravaha Srota. All the primary diseases of Mutra like Mutrakricchra, Mutraghata, Ashmari or Prameha are the consequences of Mutravaha Srotadusti. Thus in respect to modern science, Mutravaha Srotadusti can be correlated with all types of lower urinary tract infections and the diseases produced as its consequence. Aims and Objectives: The present study was carried out to evaluate the concept of Mutravaha Srota and Mutravaha Srotadusti in terms of lower UTI as well as to evaluate the efficacy of the selected drug Gokshur to combat the situation. Materials & Methods: In the selected 50 patients of lower UTI with features of Mutravaha Srotadusti, based on the inclusion and exclusion criteria, Gokshur Churna was administered in stipulated dose (5 gram twice daily with warm water) for 21 days. Observation: The subjective parameters of Mutravaha Srotadusti are present in maximum number of patients of lower UTI. The result also reveals the significant efficacy of the selected drug i.e., Gokshur Chruna to combat Mutravaha Srotadusti and lower UTI with ‘p’ value <0.001 in all subjective and objective parameters. Conclusion: The literary information which reveals that there are similarities between Mutravaha Srotadusti and lower UTI in terms of causative factors, pathogenesis and clinical features, has been clinically verified in the present study. It has also been observed that Gokshur Churna is very effective in the management of lower UTI as well as Mutravaha Srotadusti which has been verified through clinical data and statistical analysis.
Orthopaedics in Ayurveda - Bhagna Chikitsa- A Review
Authors: Ujjawal Shivhare  , Mrigank Shekhar  , Shailendra  , Tina Singhal
Published: February 2022

In the vast literature of Ayurveda, orthopaedic condition is well elaborated in the name of Bhagna Chikitsa. As per the condition Acharya Sushruta described Many of the new techniques are well developed for the management of fracture like as it’s etiology, classification, and various modalities of the management. Bhagna in ancient period were commonly faced problem occurs in war and attack by animal etc. but in the present time these are commonly as a result of Road Traffic Accident (R.T.A.). Acharya Sushruta explained Bhagna depending upon nature of trauma, shape of fracture, displacement of fracture fragment and fracture with or without wound. If it occurs in the bone it is called as Kand Bhagna (bone fracture) and in the joint it is called as Sandhimoksha (dislocation). Acharya Sushruta defined the principle of fracture of fracture management centuries ago are as per condition suggestive conservative or surgical treatment. Conservative modalities includes Kushabandh, Alepa, Chakrayoga, Taila Droni etc are still relevant and used. It would be worthwhile to explore this unique feature for use in present times. The concept, theories and techniques which were practical several thousand years ago hold true even in modern era. Purpose of this article, to re-evaluate the Bhagna.
Effect of Shoditha Hingu (Ferula Asafoetida Linn) Prayoga in the Management of Kastarthava (Primary Dysmenorrhoea) - A Case Report
Authors: Shubha M
Published: February 2022

Dysmenorrhea is one of the leading gynaecological disorders affecting women irrespective of age, economic status and the nationality. Primary dysmenorrhoea being one among the two types of dysmenorrhoea can be correlated to Kastartava in Ayurveda. Though the direct reference is not available, it can be compared to Kastartava or Udvartini yonivyapad because of upward movement of the Vata-kapha dosha along with Arthava associated with severe pain. In the present study, a female student aged 18yrs attended the OPD of Sushrutha Ayurvedic Medical College and Hospital, Bengaluru with the complaints of primary dysmenorrhoea was managed with Hingu prayoga for 3 months based on the Ayurvedic principles of management that are described in the classics by Acharyas. Significant reduction in abdominal pain and back pain was observed. Reduction of pain was stable during the three months of intervention and no adverse effects were found either during or after the treatment
Neoteric Technique towards the Management of Bhagandara w.s.r. to Blind External Fistula: Arka Kshara Sutra Varti
Authors: Aarushi Prasher  , H.S.Bali
Published: February 2022

Background: Anal fistula is a chronic inflammatory tubular structure which is supposed to communicate with the ano-rectal canal at one end and the surface of perianal skin on the other. A classical fistula has two openings, one internal and one external. The internal opening is the primary opening and denotes the source of infection from which the fistula initially developed. During the course of its development the primary opening may sometimes close and the purulent discharge flows out through the external opening only, which is termed as ‘Blind external fistula’. The description of Bhagandara described in Ayurveda can be correlated to anal fistula. Aim: The present work aims at analyzing Arka Kshara Sutra Varti (alkaline wick) employed on non-specific inter-sphincteric Grade II Fistula-in-ano where there was no internal opening (Blind-external fistula). Materials and Methods: 15 patients of Blind external Fistula were selected for Arka Kshara Sutra Varti insertion. Arka Ksharasutra Varti prepared by cutting a small piece of Arka Ksharasutra and immersed in Jatyadi oil was inserted inside the track. The Varti was changed on alternate day upto six weeks. Assessment was done on objective (Unit Healing time- UHT) and subjective parameters. Observations: Statistically highly significant results were obtained on subjective parameters like Pain, Discharge, Itching and Burning sensation. Average Unit Healing time (U.H.T.) was 7.16 days/cm. The track became clean and healed by six weeks completely without any recurrence in the subsequent follow-up of six months. 66.67% of patients had a completely healed tract.
Conclusion: Arka Ksharasutra Varti is laced with anti-bacterial, anti-fungal, bactericidal and anti- inflammatory properties which minimizes the use of antibiotics and also demolished the recurrence of symptoms. Kshara Sutra wick insertion is an effective method with negligible loss of sphincter muscle tone. The introduction of Kshara Sutra Varti in the Fistulous tract, where internal opening was not formed, is capable of dissolving the tough fibrous tissue and ultimately draining it out, thus creating a healthy base for healing.
Invitro Cytotoxicity of Various Parts of Adhahapushpi (Trichodesma Indicum Linn.R.Br.) Against 3 Cancer Cell Lines
Authors: Sarojini Byadigi  , Subrahmanya P  , Kishore G. Bhat  , Vijay Kumbar
Published: February 2022

Cancer is a leading cause of death and an important source to the mortality and morbidity worldwide. The management in contemporary medicine is having toxicity to normal cells so the world is looking forward for drugs which are cytotoxic to cancer cells and non toxic to host cells and Medicinal plants are the doing well in this aspect.  Adhahapushpi (Trichodesma indicum Linn.R.Br.)Belonging to Boraginaceae family is traditionally used as anticancer to treat breast cancer. Its cytotoxicity against breast cancer and cervical cancer is proved in previous researches. Objectives: The present study was conducted to evaluate its cytotoxicity against 3 Human cancer cell lines Viz. colon cancer cell line (HCT116), oral cancer cell line (KB) and skin cancer cell line (A375). Method: Alcohol, Methanol and Aqueous extracts of Root, Leaf, Stem and Fruit of Adhahapushpi were used to screen in-vitro cytotoxicity. Cytotoxic effect was analysed by MTT assay.

Results: The ethanol Root extract was found to be more cytotoxic in vitro to colon cancer cell line (HCT116) with IC50values 176.5±13.36 µg/ml, ethanol extract of fruit to  oral cancer cell line (KB-3-1) with IC50values 154 ± 3.89 µg/ml and root ethanol extract to skin cancer cell line (A375) with  IC50values 169± 12.09 µg/ml respectively.
A Critical Modern Review on BRVO (Branch Retinal Vein Occlusion)
Authors: Narender Chanchal  , Smriti Kaul  , Daya Shankar Singh  , Munna Kumar
Published: February 2022

Branch retinal vein occlusion (BRVO) may be a common reason behind retinal vascular disease. General vascular diseases corresponding to cardiovascular disease and induration of the arteries are risk issues for BRVO. Age is additionally a powerful risk factor for BRVO. And lots of epidemiological studies have confirmed that the prevalence will increase with increasing age. It happens most often between the ages of sixty and seventy years. Men and ladies are affected equally. Age, systemic hypertension and also the retinal artery changes related to it, together with blood vessel nicking and retinal arteriolar narrowing, are well-established risk factors for BRVO. Other vessel risk factors, reminiscent of diabetes, smoking, hyperlipidemia, chamber fibrillation, urinary organ dysfunction, and atherosclerosis, have conjointly been related to an exaggerated risk of BRVO. The pathologic interruption of blood vessel flow in eyes with BRVO nearly always happens at a blood vessel crossing. Patients with BRVO gift with unexpected painless loss of vision or a visible field defect. Prognosis and we have a tendency to the effectiveness of various treatment choices. So it's necessary to grasp the explanation of BRVO. BRVO could be a common reason behind vision loss, however several treatment options are accessible and rising therapies are under investigation. Here, we gift a review of the chance factors, pathological process in BRVO, clinical features, natural history, clinical evaluation, diagnostic workup, clinical treatments for BRVO patients also as connected clinical trials also are reviewed.
Clinical Validation of Unani Pharmacopoeial Formulation Qurs-E-Dīdān in Dīdān Al-Am‘Ā’ (Intestinal Worms)
Authors: Khan Mohammad Nafees  , Salam Mahboob  , Arshad Mohammad  , Siddiqui Ziaul Haq  , Sehar Najmus  , Ahmad Fasih  , Naime Mohammad  , Azeem Mohd Aaqil  , Akhtar Jamal  , Goswami Anirnban
Published: February 2022

Qurs-e-Dīdān is an Unani Pharmacopeial formulation which is used since ancient period by Unani Physicians for the treatment of various intestinal worm infestation. The present study was carried out at Central Research Institute of Unani Medicine, Lucknow to scientifically validate the safety and efficacy of Unani Pharmacopeial formulation Qurs-e-Dīdān in Dīdān al-Am‘ā’ (Intestinal Worms) during the period 2015 to 2017. This was an open label, single arm, interventional study in which 68 subjects of either sex were randomly selected and given Qurs-e-Dīdān 250 mg. one tablet orally twice a day before meal for two weeks and the patients were observed weekly on the basis of subjective and objective clinical parameters which were recorded and the result was assessed on the basis of reduction in sign and symptoms on 4-point (0-3) scale and the presence or absence of ova, cyst or worms in the stool examination before and after the duration of protocol therapy and analyzed statistically using student’s paired 't’ test. The result was expressed as the Mean ± SD. The ova/cyst of worms passing in stools, recurrent abdominal pain, abdominal bloating, nocturnal perianal itching, odontoprisis, water brash were improved (P<0.01).