bluuebunny/crossref_metadata_2025 huggingface dataset:
Current data about localization of acute ischemic stroke and prognostic factors in diabetic and non-diabetic patients
Authors:   Intensive Care Anesthesia Clinic, County Emergency Clinical Hospital, Oradea, Romania, POP Nicolae Ovidiu ,   Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania, BABEȘ Petru Aurel ,   Faculty of Medicine and Pharmacy, University of Oradea, Romania, HOLHOȘ Larisa Bianca ,   Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania, GAVRILUȚ Eugenia ,   Faculty of Medicine and Pharmacy, University of Oradea, Romania, MEKEREȘ Gabriel Mihai ,   Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Romania, MEKERES-RACOVIȚĂ Mariana ,   Faculty of Medicine and Pharmacy, University of Oradea, Romania, CRISTIAN Voiță Nuțu ,   Faculty of Medicine and Pharmacy, University of Oradea, Romania, IACOB-CUCIAN Alina Oana ,   County Emergency Clinical Hospital, Tg. Mures, Romania
Published: August 2021

Introduction. Ischemic stroke accounts for approximately 85% of all vascular accidents and has a high number of identified risk factors, including transient ischemic attack, smoking, metabolic syndrome, alcohol consumption, elevated cholesterol levels and artery stenosis carotid. Diabetes mellitus (DM) is a well-established risk factor for ischemic stroke. Material and method. This prospective longitudinal observational study highlights the importance of localization of ischemic stroke, including 340 patients with acute ischemic stroke with / without diabetes mellitus. The database was collected in a Microsoft Excel document. The correlation analysis was processed in the MedCalc 14.1 program where correlation tests included in the program were used. Results. The predominant localization of ischemic stroke in diabetic patients was the middle cerebral artery followed by the posterior cerebral artery and the double localization compared to the group witness where the same trend is maintained (p = 0.22). The correlation between the localization of the acute ischemic stroke with the age 64.5 for MCA, 64.6 for PCA, and 73.57 for DL (CI 95%, p= 0.02). The correlation of the NIHSS severity score with the location of ischemic strokes was also obtained: average NIHSS score 18.9 points for MCA, 18.5 for PCA, 24 for DL (CI 95, p < 0.0001). The data obtained from the Kaplan-Meier analysis on the survival rate of the patients (divided by the vascular territory involved), provided an expected result difference (statistically significant, p < 0.0001). Conclusions. There is no statistically significant difference between diabetic vs. non-diabetic patients regarding the localization correlated with DM, the double location being statistically insignificant between the two batches. The double location having a higher frequency in elderly patients.
Viral and cellular biomarkers used for improving prevention and management of cervical cancer
Authors:   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, NASTASIA Şerban ,   Department of Obstetrics and Gynecology, “Dr. Ion Cantacuzino” Clinical Hospital, Bucharest, Romania, SAVU Ana-Cătălina ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, “Dr. Ion Cantacuzino” Clinical Hospital, Bucharest, Romania, POPA Anca ,   Department of Obstetrics and Gynecology, “Dr. Ion Cantacuzino” Clinical Hospital, Bucharest, Romania, SIMIONESCU Anca Angela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, STANESCU Ana Maria Alexandra ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Familly Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, RUSSU Manuela Cristina ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, “Dr. Ion Cantacuzino” Clinical Hospital, Bucharest, Romania
Published: August 2021

Cervical cancer remains one of the preventable cause of women’s death, the second most common cause of death in Europe. Several screening tests for precancerous lesions are available, including cervicovaginal cytology and screening of high-risk human papillomavirus (HPV) strains – 16, 18, 31, 33. Cervical cytology (Babeş-Papanicolau smear test) remains the elected method for cervical cancer screening in many countries. Last decades, HPV DNA sequence was identified, including gene number and encoded proteins. HPV DNA gene expression involves the use of multiple promoters and complex patterns of splicing, which served as a model for the elaboration of cellular and molecular biomarkers for the identification. Herein, we present the usefulness and efficiency of viral and cellular biomarkers in improving the diagnosis and managing precursor lesions of cervical cancer. Viral and cellular biomarkers can help differentiating low-grade lesion leading to a better diagnosis. HPV DNA tests, although a primary screening method in actual guidelines, can serve as a better screening test method. Other viral biomarkers that include E6 and E7 mRNA testing and determining the methylation of viral genes have good test screening results. Cellular biomarkers such as the immunocytochemical staining of p16INK4a, alone or combined with the proliferation marker Ki-67, can reveal anomalies in the cell cycle. The E4 protein, strongly expressed in productive infections, can prove a transforming infection when it is absent. In recent years, detection of the TERC gene and oncogenetic microRNAs expressed early in carcinogenesis before clinical findings show great promise in differentiating lesions likely to progress to cancer. In conclusion, biomarkers are more powerful instruments to enhance early pre-cervical cancer lesions diagnosis, which allow better prognosis and more reliable treatment.
The importance of cardiovascular risk factors in approaching the hypertensive patient by the family doctor
Authors:   Pneumoftiziology Hospital, Campulung, Romania, MILITARU Cristina-Gabriela , BEJAN Gabriel Cristian ,   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, NICOLESCU Oana ,   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, GRAJDEANU Ioana Veronica ,   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, SIMIONESCU Anca Angela ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, SIMIONESCU Anca Angela ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, STĂNESCU Ana Maria Alexandra ,   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Cardiovascular diseases, such as acute myocardial infarction, stroke, peripheral arterial disease, chronic kidney disease, are a major health problem for the patient, in terms of declining quality of life, but also increasing spending on the health system. The aim of this study is to demonstrate the involvement of cardiovascular risk factors related to patients' lifestyle (salt intake, saturated fats, alcohol, smoking, sedentary lifestyle) or other modifiable risk factors (total cholesterol, triglycerides, obesity, hypertension arterial blood sugar, glycemia, metabolic syndrome), in the occurrence of cardiovascular disease and the impact of the association of risk factors in increasing the risk of cardiovascular complications.
Acute pancreatitis prevalence in children with cystic fibrosis and PIP score prediction applicability
Authors:   UMF „Carol Davila“, București, România, COMĂNICI Valentina-Daniela ,   Departamentul Pediatrie INSMC „Alessandrescu Rusescu“, București, România, CODREANU Ioana Florentina ,   UMF „Carol Davila“, București, România,   Departamentul Pediatrie INSMC „Alessandrescu Rusescu“, București, România, BĂLĂNESCU Anca ,   UMF „Carol Davila“, București, România, BELIVACĂ Alina Angelica ,   UMF „Carol Davila“, București, România, STAN Iustina Violeta ,   UMF „Carol Davila“, București, România,   Departamentul Pediatrie INSMC „Alessandrescu Rusescu“, București, România, CRAIU Mihai ,   UMF „Carol Davila“, București, România,   Departamentul Pediatrie INSMC „Alessandrescu Rusescu“, București, România, RITIVOIU Mirela-Elena ,   UMF „Carol Davila“, București, România,   Departamentul Pediatrie INSMC „Alessandrescu Rusescu“, București, România, MATEI Dumitru ,   UMF „Carol Davila“, București, România,   Departamentul Pediatrie INSMC „Alessandrescu Rusescu“, București, România
Published: August 2021

One of the affected organs in cystic fibrosis (CF) is the pancreas, mainly translated into exocrine pancreatic insufficiency. Although rare, acute pancreatitis (AP) has been described, mostly in pancreatic sufficient patients. Objectives. Estimating AP prevalence in CF pediatric population of the I.N.S.M.C. „AlessandrescuRusescu” CF centre. Material and methods. 5 year retrospective study (2011-2016) including INSMC CF centre pediatric population aged 3-18 years. PA diagnosis was established on the presence of minimum 2 criteria between: characteristic abdominal pain, x3 normal value for age elevation of amylase/lipase, medical imaging evaluation suggestive for AP. Patients were evaluated with different criteria including PIP score of predicting AP risk. Outcomes. 48 patients were included with a slight female predominance (54%). 3 of them presented diagnostic criteria for AP (6,25%), all heaving pancreatic insufficiency and high PIP score (low risk of developing AP); 2 of them have low compliance with pancreatic enzymes substitution therapy; one of them presented recurrent episodes of AP. Conclusions. AP is a rare CF complication. It can be easily missed due to a large number of abdominal pain and emesis causes in CF patients. Although it is usually associated with pancreatic sufficiency, all our patients were pancreatic insufficient.
Study of the adherence capacity of microbial biofilms on titanium versus zirconium dioxide (Zirconia) surfaces
Authors:   “Dunărea de Jos” University, Galați, Romania, MARCU Teodora , MIHAI Augustin ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BURLIBAȘA Mihai ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, POPA Marcela ,   Faculty of Biology, University of Bucharest, Romania, CRISTACHE Corina Marilena ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PERIEANU Viorel ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, CHIRILĂ Mihaela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PERIEANU Mădălina ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, MALIȚA Mădălina ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, COSTEA Radu ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, COSTEA Raluca ,   Private practice, Brașov, Romania, BABIUC Iuliana ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, TĂNASE Gabriela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BEURAN Irina Adriana ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, DRĂGAN Constantin Florin ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BURLIBAȘA Liliana ,   Faculty of Biology, University of Bucharest, Romania
Published: August 2021

Introduction. An important role in the appearance of acute or chronic infections is played by bacterial biofilms that contain several bacterial species and that develop preferentially on inert surfaces, dead tissues and medical devices. Purpose. In this material we tried to make an interesting study, regarding the adhesion capacity of microbial biofilms characteristic of the oral cavity of human subjects on the surface of materials used for industrial scale manufacturing of dental implants: titanium and zirconium dioxide (Zirconia). Material and methods. For this study were used plates of Ti4 and zirconia, on which adhesion of different bacterial strains belonging to the species Enterobacter cloacae, Klebsiella oxytoca and Klebsiella pneumonia were tested. Results and discussions. A rather high microbial load was observed on both types of materials for all types of bacterial strains studied. For certain types of strains, a lower colonization was noted in the case of zirconium dioxide compared to Ti4 surfaces. Conclusions. Although Zirconia has been reported to have a lower susceptibility to bacterial adhesion, our study contradicts this aspect specified in the literature. Both titanium and zirconium dioxide are promptly colonized by existing bacteria on the teeth left in the oral cavity
The evolution of neuropsychiatric symptoms during treatment for hyperthyroidism
Authors:   Doctoral School, University of Medicine and Pharmacy, Craiova, Romania, NICOLA (MARIOARA) Oana-Maria , GHENEA Alice Elena ,   Bacteriology-Virology-Parasitology, University of Medicine and Pharmacy, Craiova, Romania,   Clinical Emergency County Hospital, Craiova, Romania, VLĂDOIANU Cristina-Nicoleta ,   Endocrinology, Filantropia Clinical Hospital, Craiova, Romania, CARLIG Valentin ,   Pharmacology, University of Medicine and Pharmacy, Craiova, Romania, CARSOTE Mara ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Endocrinology, "C.I.Parhon" National Institute of Endocrinology, Bucharest, Romania, POPESCU Mihaela ,   Endocrinology, University of Medicine and Pharmacy, Craiova, Romania
Published: August 2021

Introduction. The link between the action of thyroid hormones and neurological, cognitive and affective function is well known. The aim of the study is to evaluate the changes of hormone’s value and symptoms at hyperthyroid patients after 6 months and 1 year of treatment. Materials and methods. In our study, we enrolled 80 patients with hyperthyroidism (new cases) and we asked them to fill out a questionnaire three times: first time was when they were into a thyrotoxic state (before the antithyroid drug therapy – ATD) and after that during ATD treatment (when they were into an euthyroid state after 6-12 months of treatment, average 7 months). Results. There is no statistically significant difference between the ages of the study and control groups (p Student’s t -test = 0.207 > 0.005), nor between the distributions according to gender (p Chi square test = 0.827) or area of residence (p Chi square test = 0.820). For HAMD score, there is highly significant differences (p < 0.001) before treatment, a statistically significant difference after 6 months (p Student’s t-test = 0.015 < 0.05), and no statistically significant difference after 1 year. Conclusion. Depression and anxiety were improved following thyroid function normalization in hyperthyroidism.
Particularities of multivessel disease in a diabetic patient
Authors:   “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania, STOICHESCU Hogea Gheorghe , SOSDEAN Raluca ,   Institute of Cardiovascular Diseases, Timisoara, Romania,   Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania, BULEU Florina ,   Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania, CHITA Dana Simona ,   Department of Neurology, Faculty of Medicine, “Vasile Goldis” Western University, Arad, Romania, CORBU Miruna ,   Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania, DRAGAN Simona Ruxanda ,   Institute of Cardiovascular Diseases, Timisoara, Romania,   Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
Published: August 2021

Atherosclerosis is a complex chronic inflammation in the large and medium arteries that is most often associated with hyperlipidemia and/or several other risk factors. Diabetes mellitus has also been shown to dramatically influence the extent and clinical complications of atherosclerosis, moreover, patients with diabetes are known to have a predisposition to develop multivessel disease. We report a case of resistant hypertension associated with multivessel disease in a diabetic patient. The presence of progressive kidney failure, initially interpreted in the context of diabetic nephropathy and found to be due to severe renal artery stenosis, and the presence of atherosclerotic disease in the previously discovered cerebral and coronary arteries and in the recently found carotid and renal artery territories, without affecting the peripheral arteries and rather unexpected in a diabetic smoker, represent particularities of this clinical case.
New aspects in nonsurgical treatment of Marshall syndrome
Authors:   Spitalul Clinic de Urgenţă pentru Copii „M.S. Curie“, Bucureşti, România, EPURE Veronica ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România, GHEORGHE Dan Cristian ,   Spitalul Clinic de Urgenţă pentru Copii „M.S. Curie“, Bucureşti, România,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România
Published: August 2021

Marshall syndrome, defined by recurrent fever episodes, angina, adenitis and stomatitis, is frequently encountered in childhood. Medical treatment consists of corticosteroids in order to solve the acute symptoms; adenotonsillectomy or alternative medication can be administered on the long term in order to prevent recurrence of symptoms. The authors present a case of Marshall syndrome; based on personal experience and data from literature, the authors draw attention on the efficiency of montelukast in preventing recurrence of episodes, as an alternative option to surgery
Is total pelvic exenteration suitable for elderly patients with locally advanced or recurrent rectal cancer?
Authors:   Department of Visceral Surgery, Center of Excellence in Translational Medicine, “Fundeni” Clinical Institute, Bucharest, Romania, BACALBASA Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BALESCU Irina ,   Department of Surgery, Ponderas Academic Hospital, Bucharest, Romania, ALOUL Adnan Al ,   Department of Surgery, Ramnicu Sarat County Hospital, Buzau, Romania,   Doctoral School, “Titu Maiorescu“ University, Bucharest, Romania
Published: August 2021

Locally advanced and relapsed rectal cancer represent one of the most commonly reported indications for total pelvic exenteration especially in men, while in women the surgical procedure might be limited to a posterior exenteration. This procedure is still associated with high risks of postoperative complications and high rates of perioperative mortality, therefore careful selection of the cases is mandatory. However, in the last decades improvement in the field of oncology treatment leaded to the increase of the lifespan of patients diagnosed with rectal cancer; in this respect, it is easy to be understood the fact that an increased number of cases will develop at a certain moment of their evolution pelvic recurrences which need more extended surgical procedures at a more advanced age. Therefore, extended procedures such as pelvic exenterations are needed in these cases; the aim of this paper is to study whether pelvic exenteration is suitable for elderly patients and which cases could benefit most from this aggressive surgical approach.
Teaching communication in medical students – a cornerstone for patient’s outcome
Authors:   European and Research Projects Department, George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, Tg. Mures, Romania, SUCIU Nicoleta , MELIȚ Lorena Elena ,   Department of Pediatrics I, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, Tg. Mures, Romania, MĂRGINEAN Cristina Oana ,   Department of Pediatrics I, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology, Tg. Mures, Romania
Published: August 2021

Communication is definitely one of the most important contributing factor for an ideal doctor-patient relationship. The major importance of communication is to build a proper relationship with the patients, in which the empathy and respect play an essential role and can be taught and improved with proper training. This process is defined as cross-culture communication and it has to be taught during medical school. Patient-centered communication is a concept closely related to cross-culture communication and it might be defined by the physician’s ability to tailor communication to each patient’s need and level of understanding in order to provide patient-centered care. Training of clinical communication skills in medical students is an incontestable emergency for the patient’s outcome. Medical education formerly focused on training students for solving only the medical problems by providing the treatment for their organic problems. Medical schools recently included in undergraduate curricula clinical communication courses in order to improve student’s and future physician’s the ability to obtain relevant information from their patients, to build strong doctorpatient relationships and provide patient-centered care. Various models were elaborated for teaching and assessing clinical communication skills, which were found to improve multiple aspects of physician-patient communication among which counseling, interviewing techniques and prescription. Medical schools should properly address to clinical communication skills by including training courses in each year of education focused on the specific of the learned medical fields. It is crucial for implementing proper assessment methods in order to prevent and diminish as much as possible the factors that might negatively impact the development of doctor-patient relationship. Proper medical training in terms of clinical communication skills should be initiated during medical school in all students that deal with patients, but also after the graduation, periodically in all health care providers for assuring an ideal outcome for their patients.
Statin-induced myopathy – a challenge for patients and physicians
Authors:   Department of Internal Medicine, Ilfov County Clinical Hospital, Bucharest, Romania, ANGELESCU Gabriela Anca ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, TOMA Mirela Marioara ,   Department of Pharmacy, Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Romania, VARLAS Valentin ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynaecology, Filantropia Clinical Hospital, Bucharest, Romania
Published: August 2021

Statins are the most frequently used drugs for lowering the low density lipoprotein (LDL)-cholesterol and are proven to decrease the cardiovascular-driven mortality. The statin-induced myopathy represents a side effect of the statin therapy and includes heterogenous muscular symptoms, associated with an increase in the creatine kinase (CK) levels, according to clinical trials, at an incidence of 1.5-5%. The statin-induced myopathy is challenging for clinicians, in order to maintain the specific therapeutic approach for each case, as well as for patients at a high risk of cardiovascular diseases, who acknowledges the long-term benefits of the treatment. The aim of this review article is to showcase the types of statin-induced myopathy, the patient cohorts susceptible of developing this side effect and the treatment strategies for hypercholesterolemia/ dyslipidemia.
Immunity and COVID-19 vaccines in pregnancy – precautions and risks
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, SIMIONESCU Anca A. ,   Filantropia Clinical Hospital, Bucharest, Romania, BEJAN Gabriel Cristian ,   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, ADAM Ana-Maria ,   Department of Surgery, “Dunarea de Jos” University of Medicine and Pharmacy, Galati, Romania, STANESCU Ana Maria Alexandra ,   Department of Family Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Symptomatic coronavirus disease (COVID-19) during pregnancy represent a high-risk situation for maternal complications, including respiratory distress, pneumonia and even death. Pregnancy represents a unique adaptative immunological and hormonal state at the inflammatory response. At this time, global immunization is a promising way to stop this pandemic. Since early December 2020, more than 150 vaccine candidates in various stages of development and research are communicated. In Romania, there are four vaccines authorized by the European Medicines Agency (EMA): Pfizer–BioNTech, Moderna, Oxford– AstraZeneca and Johnson & Johnson. However, many people are reluctant to take the COVID-19 vaccine, including false beliefs about this use during pregnancy. Herein, we present the current state of knowledge about immunity and COVID-19 vaccines during pregnancy based on reported cases from medical literature. Most of them are reported from healthcare pregnant women in COVID-19 facilities or in women in the first trimester of pregnancy who did not know they were pregnant at the time of vaccination. The Eudravigilance from European Medicines Agency (EMA) constantly monitors any side effects after a vaccine. COVID-19 vaccination during pregnancy is proving to be as safe and effective as in the general population. Because COVID-19 vaccines have been observed in association with a higher rate of miscarriage in early pregnancy, it should be used with caution in the first trimester. Vaccination before planning a pregnancy in order to gain immunity at the time of conception is recommended.
What’s new about multiple sclerosis and pregnancy?
Authors:   Filantropia Clinical Hospital, Bucharest, Romania, DUMINICA Ana Turcu , GICA Nicolae ,   Filantropia Clinical Hospital, Bucharest, Romania, BOTEZATU Radu ,   Filantropia Clinical Hospital, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, CIOBANU Anca Marina ,   Filantropia Clinical Hospital, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, CIMPOCA Brindusa Ana ,   Filantropia Clinical Hospital, Bucharest, Romania, GICA Corina ,   Filantropia Clinical Hospital, Bucharest, Romania, PELTECU Gheorghe ,   Filantropia Clinical Hospital, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, PANAITESCU Anca Maria ,   Filantropia Clinical Hospital, Bucharest, Romania,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Nowadays, women diagnosed with multiple sclerosis and belonging to the reproductive age group have high pregnancy rates, thus increasing the need of a careful pregnancy management in order to avoid maternal and fetal complications. The challenge of the chosen subject consists in identifying the available treatment that can be used during pregnancy time, emphasizing the need of a rigorous care during the preconceptional and postpartum period. The aim of the current review is to describe the management of a pregnant woman diagnosed with multiple sclerosis, in regards of treatment, anesthesia, mode of delivery and management and prevention of relapses during the postpartum period.
Presentación atípica de celulitis orbitaria en recién nacido
Authors: Planchet Jenny , Rojas Koana , Blanco Pedro
Published: August 2021

Orbital cellulitis represents a frequent cause of inflammation of the orbit, constituting a medical emergency that requires multidisciplinary management. We present a case of a newborn with clinic of volume increase in right bipalpebral region and fever of 24 hours of evolution. Physical examination reveals proptosis of right eye, increase of bipalpebral volume that prevents the opening of the eyeball in its entirety with signs of flushing and purulent eyelid margin secretion. Laboratories report leukocytosis and reactive thrombosis; orbital tomography scan shows right periorbital swelling and edema, diffuse increase of extra and intraconal post-septal fat density, suggestive findings of right orbital cellulitis, covered with vancomycin and cefotaxime; subsequently requires abscess drainage where Staphylococcus aureus methycilin- resistant is isolated. Being an unusual pathology in this age group, the publication of this case is recommended. Key word: Celullitis, orbital abcess, new born
Índice de masa corporal, peso ideal y porcentaje de grasa corporal en personas de diferentes grupos etarios
Authors: Bauce Gerardo
Published: August 2021

The objective is to compare BMI with the percentage of body fat and ideal weight, to supplement BMI in the diagnosis of obesity, from a group of adults. METHODS: descriptive, cross-cutting, prospective and correlational study, in a sample of 797 adults between 17 and 96 years old, attended in different clinical centers of Caracas, between 2015 and 2018. The variables are: age, weight, size and BMI was calculated, percentage of body fat (BFP) and ideal weight (IW). They were classified by sex, age group and BMI in normality and obesity. Two formulas were used for BFP: Deurenberg and Regression; and three formulas for IW: Lorenz, Ramirez-Lopez et al and Broca. Descriptive measures, association, correlation, average comparison and normality test were obtained, using Excel software, Epidat.2. RESULT: BMI and BFP averages increase to 40 years and decrease to age 79, the variables Size – IW Broca, and BMI- BFPR correlate well (r>0.75). The average BMI, BFPD, BFPR, IW Broca and IW Lorenz, depending on gender, are significant (p<0.000); for BMI, in Normality and Obesity, the weight averages, BMI, BFPD and BFPR are higher in the Obesity group, and significant (p<0,000). The Shapiro-France normality test found that the distribution of BMI, BFPD, BFPR and IW Lorenz, comes from a normally distributed population (p< 0.000). CONCLUSIONS: BMI even though it is most commonly used to diagnose obesity, it classifies normally, those with a high percentage of body fat.
Análisis de la curva ROC en la evaluación de indicadores antropométricos
Authors: Bauce Gerardo , Moya-Sifontes Mary
Published: August 2021

Evaluation of the Waist Weight-Circumference Index (WWCI) using Logistic Regression. Descriptive, prospective and cross-sectional study shows 1095 adults and older adults, aged between 20 and 96 years. Methods: variables: age, weight, size, Waist Circumference (WC), BMI, Waist-Size Index (WSI). Results: Similar BMI in both sexes; higher WC and WSI averages in a ≥ age of 65; major WWCI in group 20-59 years; WWCI risk rate (54.1%) higher in WC (44.7%) WSI (78.2%). WWSI significantly associated with BMI, WC and WSI (p<0.000); positive predictive value 0.92 and negative predictive value 0.70, indicate discriminatory capacity; Relative Risk, 1.92; Wald test statistic indicates statistical significance for the coefficients of risk probability equations; area under the ROC curve is 0.803 and 0.903 (P<0.000), high sensitivity and specificity. Conclusion: WWCI can be considered to evaluate overweight and obesity in adults, given its high discriminatory capacity.
Dos fórmulas para calcular el IMC, y su relación con otros indicadores antropométricos en adultos
Authors: Bauce Gerardo
Published: August 2021

Descriptive, prospective, transversal and correlational study, whose objective is to relate two formulas for calculating BMI, with other indicators, in a group of adults. METHODS: The sample is of 137 adult patients who attended consultation at the University Hospital of Caracas. The variables are: age, weight, size, BMI-Q, BMI-O, WC, WSI, WCWP and BFP. Averages, deviations, percentages and z-tests and Mann Whitney were obtained to compare averages and Median. RESULTS: Similar BMI-Q averages in both sexes, and older BMI-O in female sex. The two formulas for calculating BMI result in the highest percentage with BMI-O, higher overweight percentage with BMI-Q and significant (p<0.000) and percentages of Healthy Weight and Obesity equal. Equal averages, per group, of BFP for the two BMI formulas, and increase from Healthy Weight to Obesity. The Coefficient of Variation reveals more homogeneity in BMI-O (18.41% vs 25.21%). BMI-Q correlates with weight (0.91), WC (0.92) and WSI (0.93); IMC-O with weight (0.97), WC (0.83) and WCWI (0.90). Whitney's test reveals that averages by sex are significant (p<0,000), as are IPCC averages per sex (p<0.000). In addition, the BMI Oxford, WC, WSI and WCWI indicators have sensitivity of 92,3%, 92.3% and 92.3%, respectively. CONCLUSION: The BMI Oxford for its somewhat complicated calculation formula is not recommended to evaluate overweight and obesity, in adults.
Correlación clínico patológica de los ganglios cervicales en pacientes con cáncer de cabeza y cuello
Authors: Sánchez Kimberly , Valls Juan
Published: August 2021

Objective: To correlate the clinical lymph node classification with the pathological result of neck dissections performed in patients with head and neck cancer at the Otorhinolaryngology Department of the Hospital Universitario de Caracas from January 1, 2011 to December 31, 2016. Method: Descriptive, quantitative and retrospective study, which evaluated 27 patients, who underwent classical radical, modified radical and selective neck dissection. Results: average age 56 years, 77.8% male. The most frequent histological type was squamous carcinoma 81.5%. The most used type of dissection was selective 53.3%, followed by the classical radical 26.7% and the modified radical 20.0%, of these 36% presented local or cervical recurrence. Of the 16 patients with positive lymph nodes, 13 had patology confirmation, and all the negative nodes also had negative patology confirmation; regarding cervical recurrence, of the 7 cases where it was present, all positive nodes, and in the 11 patients negative nodes, all negative cervical recurrence. Conclusion: The relationship between the pathological and clinical classification, as well as the presence of positive lymph nodes in cervical recurrences are statistically significant and are related to the decrease in survival. Neck palpation continues to be a useful tool in therapeutic decision making, which has shown higher than average sensitivity and specificity.
Skin Temperature Distribution on Simulation Thermal Effects Under Construction Climate
Authors: Ahmad Rasdan Ismail  , Norfadzilah Jusoh  , Nor Kamilah Makhtar  , Raemy Md Zain  , Nurul Husna Che Hassan  , Nor Kamaliana Khamis
Published: August 2021

Global warming is bringing more frequent and severe heat waves. Construction workers are particularly vulnerable to heat risk due to the job culture in the outdoor environment. Unrestrained heat has extreme effects on skin temperature, which will lead to low performance and also results to injuries and fatalities. This study aims to investigate the distribution of skin surface temperature under seven different thermal conditions involving variations in temperature and relative humidity. The computational simulation models based on real construction climate were developed. Simulation results showed the highest heat index (a combination of temperature/relative humidity) is at 34 oC/92% and 38 oC/83% and fall under extreme danger category. At this level, the models were experienced high heat/sunstroke continuous exposure. This study also indicated that skin temperature has significantly in?uenced by the hot and humid environment. It is hoped that this study is able to provide guidance and reference to the industry, especially the construction sector by providing appropriate control measures to overcome the issue of heat risk among workers.
Boundary Layer Flow of Dusty Williamson Fluid with Variable Viscosity Effect Over a Stretching Sheet
Authors: Nur Syamilah Arifin  , Abdul Rahman Mohd Kasim  , Syazwani Mohd Zokri  , Mohd Zuki Salleh
Published: August 2021

Numerical investigation of the boundary layer flow of Williamson fluid with the presence of dust particles over a stretching sheet is carried out by taking into account the variable viscosity effect and Newtonian heating boundary condition. The genuinely two-phase flow model which has been proved to be compatible to present the mutual relationship between non-Newtonian fluid and solid particles is considered in this present study. To be precise, the governing equations are initially transformed into ordinary differential equations through formulation process before proceeding further with the numerical computation by using Keller-box method. The resulting equations are then programmed in Matlab software. The obtained numerical results are validated with existing study found in open literature and a good agreement is achieved. The influence of pertinent parameters on velocity and temperature profiles, skin friction coefficient together with Nusselt number is presented in graphical and tabular forms. Results revealed that the increasing Williamson parameter decreases the fluid velocity of both fluid and dust phases. It is expected that the present numerical results could conceivably help in predicting the boundary layer problem arising in two-phase flow in the future.
Finite Volume Method Numerical Modelling of the Penstock Flows in Dam Intake Sector Subjected to Varying Operating Conditions with Particle Image Velocimetry Validation
Authors: Nazirul Mubin Zahari  , Mohd Hafiz Zawawi  , Fei Chong Ng  , Mohamad Aizat Abas  , Farah Nurhikmah  , Nurhanani Abd Aziz  , Lun Hao Tung  , Iszmir Nazmi Ismail  , Lariyah Mohd Sidek  , Mohd Rashid Mohd Radzi
Published: August 2021

The formation of vortex and swirling in any flow structures of the hydropower dam is undesirable, as it reduced the performance of turbine as well as lowered the efficiency of hydroelectric power generation. Furthermore, it could lead to the hydraulic losses at the entrance of power intakes, the blockage at the trash racks due to entrain debris and the reduction of the working life of turbines. This paper studied penstocks flows in the dam intake section numerically. The dynamics of penstocks flows at different operating conditions were analyzed to determine the vortex formation. To access the veracity of the current proposed numerical model, a validating study based on the particle image velocimetry (PIV) experiment was conducted. It was found the discrepancy between both numerical and experimental flow velocities is 12%, implying the numerical model is well-validated and the corresponding findings are acceptable. It was found that the vortex was formed in the penstock that located at the lowest level relative to other penstocks. Furthermore, the highest pressure of 4 MPa was recorded at the bottom section of the penstock which observed vortex. This numerical work provided useful insights for the future dam reliability analysis, particularly involving penstocks and intake section.
Turbulent Axisymmetric Non-Isothermal Flow of The Hitec Molten Salt with Temperature Dependent Properties: A Numerical Investigation
Authors: Ahmed I. ElShafei  , Amr Guaily  , Mohammed A. Boraey
Published: August 2021

This study aims to investigate the Hitec molten salt’s thermal-hydraulic behavior in a smooth round pipe under broad ranges of surface heat flux and Reynolds number (q = 104 – 105 W/m2, Re = 104 – 105). Mesh independent study was performed to ensure the robustness of the model to achieve accurate solutions. Presentation of temperature, pressure and thermophysical properties for multiple cases are presented and discussed. Temperature gradient decreases at high Reynolds number leading to small change in thermo-physical properties. While pressure seems not to be affected by the change in the applied surface heat flux, it increasess linearly across the pipe with the increase in Reynolds number. This analysis aims to provide better understanding of the thermal-hydraulic behavior for fluids with temperature dependent properties for a wide range of Re and surface heat flux.
The Effect of Baffle Configuration on Heat Transfer and Pressure Drop Characteristics of Jet Impingement System with Cross-Flow
Authors: Sabu Kurian  , Tide P Sunny  , Biju N
Published: August 2021

Use of baffles in jet impingement systems in presence of initial cross-flow disturbs boundary layer that results in rise in heat transfer. Two configurations of baffle assisted impingement systems were considered and a comparative study on heat transfer and pressure drop is carried out based on operating parameters such as baffle clearance, blow ratio and h/D ratio using commercially available CFD package. Numerical predictions showed that both heat transfer and pressure drop in segmented configuration were higher than louvered configuration for all blow ratio employed in this study. Parametric studies showed that, thermo-hydraulic performance parameter is higher only for louvered configurations at low blow ratio. When cross-flow velocity is comparable with jet velocity, segmented baffles resulted in relatively higher thermo-hydraulic performance because of its higher heat transfer rate relative to the incurring pressure drop. An increase in clearance proportionally increases performance parameter. However, as jet to plate distance increases, thermo hydraulic performance declines significantly.
Comparison of Multi-Detector Computed Tomography Coronary Angiography with Invasive Coronary Angiography in Patients with Coronary Artery Disease
Authors: ŞAHİN Mahmut , GÖRMELİ Cemile Ayşe , DAĞ Nurullah , KURT Fuat
Published: August 2021

Aim: This study aimed to investigate the accuracy of multi-detector computed tomography (MDCT) coronary angiography via comparing with the invasive coronary angiography (ICA). Material and Method: Sixty-three patients (42 male, 21 female) that presented with chest pain and underwent MDCT, followed by ICA within one month were evaluated. The age of the patients ranged from 35 to 75 years. The coronary arteries were examined over a total of 15 segments according to American Heart Association classification. The detected stenoses of coronary artery were divided into four groups; non-obstructive (1-49%), significant stenosis (50-74%), high-grade stenosis (75-99%), and occlusion (100%). Segment-based and patient-based analyses were performed. The results of MDCT coronary angiography and ICA were compared. The sensitivity, specificity, positive predictive and negative predictive values were calculated by comparing the MDCT coronary angiography and ICA data.Results: In the segment-based analysis, regardless of the stenosis rate, the sensitivity was 90.8%, specificity was 95%, positive predictive value was 82.7% and negative predictive value was 97.5%. In the segment-based analysis regarding the detection of ≥ 50% stenosis, the sensitivity specificity, positive predictive and negative predictive values were 89.6%, 95.9%, 59.0%, and 99.2%, respectively. In the patient-based analysis regarding the detection of ≥ 50% stenosis, the sensitivity was 96.2%, specificity was 66.6%, positive predictive value was 68.4%, and negative predictive value was 96%. Conclusion: MDCT coronary angiography is an examination that can be used as a non-invasive method for patients in the low and medium risk group for coronary artery disease.
Food Additives and Genotoxicity
Authors: ALTUNKAYNAK Pınar , AVULOĞLU YILMAZ Ece
Published: August 2021

In today's changing conditions, there has been an increase in the consumption of ready-made food with the change in eating habits. Moreover, parallel to the increase in ready-made food production, there has been an increase in the food additives used. The dose amounts of food additives are determined as a result of experimental analyses. However, some additives show long-term toxic effects on the human body in genotoxicity tests. In this review, definition of substances, purposes of usage, classification, genotoxicity, definitions of tests and publications of genotoxicity studies in food additives were discussed. The search was conducted in peer-reviewed journals using Science-Direct, Web of Science and Google Scholar. In this study, genotoxicity studies conducted with food additives between 2015-2021 were complied. For this purpose, the keywords ‘‘food additive’’, ‘‘genotoxicity’’ were used together and research articles were included in this study.
İlkyardım Yönetmeliğine Göre Verilen İlk Yardım Eğitiminin Kalitesi Ve Çalışanlar Üzerindeki Etkisinin Ölçümü
Authors: KARAMUSTAFA Merve , BİNİCİ Ceylan Merve , ÇELEBİ Uğur Buğra
Published: August 2021

6331 sayılı iş güvenliği kanunu ve bağlı yönetmelikleri çalışanlara iş sağlığı ve güvenliği eğitimi dışında, ilk yardım, acil durum eğitimi gibi eğitimler aldırılmasını zorunlu tutmaktadır. İlk yardım yönetmeliğine göre az tehlikeli işyerlerinde 20 çalışan için 1 kişiye ilk yardım eğitimi verilmelidir. Bu kapsamda bir devlet üniversitesinde ilk yardım eğitimi almaya gönüllü olan 39 kişinin eğitim öncesi ve sonrası bilgileri test edilmiş, demografik özellikleri analiz edilmiştir. Anket uygulamasına katılan fakat eğitim sonunda yapılan yazılı/teorik sınavı geçemeyerek, ilk yardımcı belgesi almaya hak kazanamayan 9 kişinin ön testleri iptal edilmiş, analize 30 kişinin verileri ile devam edilmiştir. Anket sonuçları SPSS ile değerlendirilmiş ve yorumlanmıştır. Örneklem sayısı 30 altı olduğundan Wilcoxon yöntemine göre analiz edilmiş, test analiz sonuçları istatistiksel olarak anlamlı bulunmuştur. Test sonuçlarına göre ilk yardım eğitimi uygulanmadan önce çalışanların değerlendirmelerinin ortalaması 4,12 standart sapması 0,56’dır. Eğitimin ardından bu değerler sırasıyla 4,52 ve 0,56 olmuşlar. Eğitime katılanların kurumda aldıkları görevlere bakıldığında çoğunluğunun laboratuvarlarda çalışan akademik veya idari personel (teknisyen, tekniker vb.) olduğu görülmüştür. Evlilerin ve özellikle çocuğu olanların ilk yardım eğitimine daha çok ilgi gösterdikleri gözlenmiştir. İki günlük ilk yardım eğitimi sonunda üniversitede görev yapan idari ve akademik personelin ilk yardım bilgi düzeyinin genel olarak yükseldiği görülmektedir. Kişilerin eğitim aldıktan sonra ilk yardım uygulamalarına karşı daha özgüvenli oldukları, iş ve sosyal çevrelerindekileri de eğitim alma konusunda cesaretlendirdikleri sonucuna varılmıştır. Bu bağlamda üniversitede görev yapan ve öğrencilerle birebir çalışan akademik ve idari personelin acil durumlara müdahale yetkinliğinin arttırılması amacıyla ilk yardım uygulamalarına yönelik hizmet içi eğitimlerin artırılması gerekmektedir.
The first record of the monospecific genus Rhinopalpa (Lepidoptera: Nymphalidae) from China
Authors: He Qiu-Ju , Shi Wen , Li Chen-Yang , Yi Chuan-Hui , Jiang Zhuo-Heng , Hu Shao-Ji , Zhang Hui-Hong
Published: August 2021

The family Nymphalidae is the largest group of butterflies with high species richeness. Rhinopalpa polynice (Cramer, [1779]), a forest species, was discovered in the mid-stream of the Yuanjiang-Red River Valley of Yunnan Province for the first time, which represents the first record of the genus Rhinopalpa in China.

The species R. polynice (Cramer, [1779]) is the first record of the genus Rhinopalpa from China. The specimen was collected in the mid-stream of the Yuanjiang-Red River Valley of Yunnan Province. The female genitalia are described for the first time.