bluuebunny/crossref_metadata_2025 huggingface dataset:
İnternet Sağlık Haberlerinde Tıbbileştirmenin İnşaası: Sağlık Haber Söylemine Eleştirel Bir Bakış
Authors: BİLİŞLİ Yasemin
Published: October 2019

Tıbbileştirme, tıbbi
olmayan bir sorunu tanımlamak için tıbbi terimler kullanılmasını, bir sorunun
tıbbi çerçeveden sunulmasını veya onu “tedavi etmek" amacıyla tıbbi bir
müdahalenin gerekliliğini ifade eder. Bu sorun tıp mesleğini ilgilendiren bir
sorun olarak karşımıza çıkabileceği gibi, tıp mesleğini ilgilendirmeyen bir
durum da olabilir. Bu doğrultuda çalışmanın amacı, sağlık haberlerinde sıklıkla
kullanılan ve sağlık okuryazarlık düzeyi düşük bireyleri yanıltma ve sağlığı
olumsuz yönde etkileme ihtimali olan, yaşlanmanın tıbbileştirilmesini, bir
yazın taraması yaparak ve haberlerde yer alan ifadelerle sunarak ortaya koymaya
çalışmaktır. Bu amaç doğrultusunda Sabah, Yeni Şafak, Hürriyet ve Milliyet gazetelerinde
01.01.2017- 31.12.2017 tarihleri arasında yayımlanan, içerisinde yaşlanma
terimi geçen sağlık içerikli metinler eleştirel söylem analizinin sunduğu
kuramsal ve metodolojik pencereden çözümlenmiştir.

Çalışmada kuramsal
anlamda tüketim kültürü kuramının yanında sağlık anlayışının değişimi ve yeni
sağlık anlayışının oluşumu da değerlendirilmiştir. Araştırmanın sonucunda;
internet gazetelerinde sağlık söylemi ile yaşamın doğal sürecinde yer alan
yaşlanmanın tıbbi açıdan ele alındığı ve çözümünün birey düzeyinde
konumlandırılarak tıbbileştirilirken öte yandan okuyucuları tüketime teşvik
ettiği tespit edilmiştir.
Voleybolcularda Duygusal Zeka İle Örgütsel Bağlılık İlişkisinin Bazı Değişkenler Açısından İncelenmesi
Authors: BAHADIR Tolga Kaan
Published: October 2019

Bu
araştırma, bayan voleybol takım oyuncularının duygusal zekâ ve örgütsel
bağlılıklarını arasındaki ilişkiyi bazı değişkenler açısından incelemek
amacıyla yapılmıştır. Bu araştırmanın denek grubunu 16-32 üstü yaş aralığındaki
Türkiye sultanlar liginde yer alan Galatasaray, Beşiktaş, Eczacıbaşı, Vakıfbank
ve Fenerbahçe spor kulübünde oynayan 104 bayan sporcular oluşturmaktadır.      Bu
araştırma voleybolcuların demografik bilgilerinin yanı sıra “Duygusal Zekâ
Ölçeği” ve “Örgütsel Bağlılık Ölçeği” veri toplama aracı olarak kullanılmıştır.
Verilerin analizinde frekans(n) ve yüzde(%) değerleri
hesaplanmıştır.
Ayrıca araştırmada değişkenler arasındaki farkı bulabilmek amacıyla bağımsız T-testi, Varyans analizi
ve korelasyon (r istatistiği) testleri yapılmıştır. Araştırmanın anlam düzeyi
p< 0,05 ve p< 0,01 olarak kabul edilmiştir. Araştırma sonucunda ücret
yeterliliğinin örgütsel bağlılığın alt konularından olan duygusal bağlılık
arasında anlamlı farklılıklar bulunmuştur. Ayrıca voleybolcuların duygusal zekaları
ile örgütsel bağlılık durumları arasındaki korelasyon sonuçlarında anlamlı
farklılıklar bulunmuştur. Bununla beraber demografik bilgilerle alakalı yaş, oynadığı
voleybol yılı, şuan kulübünde oynadığı yıl ve eğitim durumu ile alakalı
sporcuların duygusal zeka ve örgütsel bağlılık durumları arasındaki korelasyon
sonuçlarında da anlamlı farklılıklar görülmüştür.

Bu
araştırmanın genel sonuçlarının,  başta
Türkiye Voleybol Federasyonu olmak üzere profesyonel bayan voleybol takımlarını
yöneten teknik ve idari ekiplerin, 
voleybolcularının duygusal zekâ ve örgütsel bağlılık düzeylerini
arttırıcı çalışmalar yapmasında rehber olması beklenmektedir.
In vitro healing efficacy of stem cell secretome and cord blood platelet lysate on a chronic wound model
Authors: Beevi Syed Sultan , Bhale Aishwarya , Panchal Nagesh , Siddiqui Sifa Abdul Wasay , Anbarasu Kavitha , Verma Vinod Kumar
Published: October 2019

Purpose: A chronic wound model provides an opportunity to understand fundamental mechanisms that could possibly provide leads for novel diagnostic molecules. An in vitro chronic wound model was created to evaluate the healing potential of stem cell (SC) secretome obtained from human umbilical cord-derived mesenchymal stem cells (hUCMSCs) and cord blood platelet lysate (CBPL).
Methods: hUCMSCs were obtained from explant culture of umbilical cord. SC secretome was collected from cells at passage 2 after appropriate SC characterisation. Platelets were isolated from cord blood and exposed to a repeated freeze–thaw cycle to obtain CBPL. An in vitro chronic wound model was created using dimethyl sulfoxide (DMSO) and hypoxia in HEK293 cells through scratch in a cell monolayer. Wounds were exposed to SC secretome and CBPL and their wound closure efficacy was calculated as relative wound density (RWD%) at defined time points.
Results: MSCs with typical spindle-shaped morphology were isolated from explant culture that sustained their stemness and morphology until up to passage 10. DMSO efficiently impeded the movement of cells into the wound area to generate a chronic wound model which was efficiently removed upon addition of SC secretome and CBPL.
Conclusion: A transient in vitro chronic wound model was created successfully to determine the healing efficiency of SC secretome and CBPL.
Severe Obstructive Sleep Apnea in an young Adult
Authors: Yasmin Fatema , Khanam Rawshan Arra
Published: October 2019

Obstructive Sleep Apnea (OSA) is a serious common sleep disorder needs life long care. OSA is caused by recurrentupper airway obstruction due to increased upper airway collapsibility during sleep. It is highly associated with obesitywith several endocrine and metabolic diseases. Hypothyroidism may cause OSA, also linked with obesity. Obesity isalso a risk factor for hypertension.This paper is presenting a case of obstructive sleep apnea with obesity, hypertensionand hypothyroidism. A 35 years old male presented with the complaints of excessive day time sleepiness, loud snoring,fragmented sleep, apnea like attack, occasional morning headache. Whole night polysomnography was done anddiagnosed as severe obstructive sleep apnea. At therapeutic part of polysomnography, he was treated with BiPAP.

BangladeshCrit Care J September 2019; 7(2): 109-110
Evaluación de una estrategia de sensibilización para desestimular el uso de bolsas plásticas en usuarios de supermercados del municipio del Socorro (Santander)
Authors: Bolívar-Lamus Adriana Milena , Gamboa-Peña Mónica Dayana , Granados-Núñez Jenifer Dayana , Guauque-Torres María del Pilar
Published: October 2019

En Colombia se generan más de 1.300.000 toneladas de resinas poliméricas y de ellas el 56% es usado para la producción de empaques como bolsas plásticas cuya principal característica es el uso por tiempo reducido y única vez aumentando la cantidad de material que es desechado con una biodegradabilidad mínima, lo que acentúa su impacto ambiental. Por esta razón, es necesario implementar diversas estrategias de sensibilización ambiental para desestimular el uso de bolsas plásticas. Para ello, se estudió el impacto de diversas estrategias visuales en el municipio del Socorro (Santander) y se encontró que más del 80% de la población conoce las consecuencias del uso indiscriminado de bolsas plásticas, pero no implementan prácticas que disminuyan tal impacto. Así mismo, se encontró que el uso de estímulos visuales que apelan a respuestas no conscientes de los habitantes puede generar una disminución en la elección del uso de bolsas plásticas en el momento de la compra
A INFLUÊNCIA DAS AÇÕES EDUCATIVAS NA GESTÃO DE PESSOAS DAS INSTITUIÇÕES DE SAÚDE
Authors: Miranda Fernanda Maria de , Alvares Paola Lefcadito , Petroni Carlos Eduardo Gatti
Published: October 2019

Tendo em vista a importância da gestão de pessoas para as organizações de saúde brasileira e as recentes colaborações organizacionais para a criação e manutenção de ações educativas nestes cenários este estudo tem como objetivo identificar a influência da educação continuada em saúde (ECS) ou educação permanente em saúde (EPS) na Gestão de Pessoas nos Serviços de Saúde brasileiros. Trata-se de uma revisão integrativa da literatura de 22 artigos completos, das bases BDENF, SCIELO, LILACS e MEDLINE, publicados em português, a partir dos descritores controlados “Education, Continuing”, “Personnel Management” e “Health”. Foi possível identificar aumento da publicação científica sobre a temática e cinco núcleos de sentido, a saber: O foco da EPS é a pessoa que trabalha; O inefável Apoio Institucional; ECS/EPS como instrumento de Gestão; Políticas de Gestão de Pessoas; Emersão da Saúde do trabalhador através da EPS.Palavras-Chave: Gestão de Pessoas. Educação Continuada. Serviços de Saúde. THE INFLUENCE OF EDUCATIONAL ACTIONS IN HEALTH INSTITUTIONS PERSONNEL MANAGEMENTAbstract: Considering the importance of personnel management for Brazilian health organizations and the recent organizational collaborations to create and maintain educational actions in these scenarios, this study aims to identify the influence of continuing education or permanent education in health personnel management in the Brazilian Health Services. It is an integrative literature review of 22 complete articles, from the databases BDENF, SCIELO, LILACS and MEDLINE, published in Portuguese, summarized from the controlled descriptions "Education, Continuing", "Personnel Management" and "Health". It was identified an increase in the scientific publication on this subject and five nuclei of meaning, called: The focus of EPS is the work person; The ineffable Institutional Support; ECS/EPS as a management tool; Personnel Management Policies; Emersion of Workers' Health through EPS.Keywords: Education Continuing. Personnel Management. Health Services.
EXPERIMENTATION: A LABYRINTH / A MAZE
Authors: Valencia Phebe
Published: October 2019

In developing designs expertise we need collaboration in various fields of science, there is no design can exist in isolation. Design is always related, sometimes in very complex ways, to an entire constellation on influencing situations and attitudes. What we call a good design is one which achieves integrity – that is, unity or wholeness – in balanced relation to its environment. From collaboration we will know how to think differently, tackle matters from a new perspective and enhance knowledge. Therefore, to develop this design expertise, a collaborative project between fine arts and interior design is done, where the project aims to tell the meaning of a space by using illustration and installation. At the end, the expectations of this project can bring a deeper understanding of the meaningful space through a story
RUMAH ADAT BATAK TOBA DAN ORNAMENNYA DESA JANGGA DOLOK, KABUPATEN TOBA – SAMOSIR
Authors: Siahaan Uras
Published: October 2019

In Indonesia there are various ethnic groups with very diverse and rich customs.On average each ethnic group has their own Traditional House, which is different fromeach other. This attracted the attention of writers, to examine the types and types ofToba Batak Traditional Houses and their ornaments. The first opportunity to examineBatak Traditional Houses was obtained in 1985, where I could enjoy the beauty of thetraditional Toba Batak houses and record them, as material for further research later.The development of Batak Traditional Houses and Settlements shows that theattention of the Batak people and their Regional Governments to the rich culturalheritage of the Batak people through their traditional houses has not received seriousattention. In 2016 there was an opportunity to review the condition of tourism in Tapanuli,along with the existence of traditional houses. The opportunity occurred through thedisaster in the village of Jangga Dolok, where 5 traditional houses once burned on NewYear's Eve 2015 to 2016This paper is intended to provide an overview of settlements and traditional TobaBatak houses, rebuilding a traditional house and the types of ornaments in theirtraditional houses. In addition, there are also ways to prevent and prevent fire hazardsfor types of houses such as Batak Traditional Houses.Keywords: Traditional Houses, Toba Bataks and Ornaments.
POLA TATA RUANG DAN STRUKTUR RUMAH TRADISIONAL MANTRAN WETAN MAGELANG
Authors: Sudarwani Margareta Maria
Published: October 2019

Mantran Wetan is located in the administrative area of Girirejo Village, NgablakSubdistrict, Magelang Regency, which is ± 25 Km from the direction of MagelangRegency towards Salatiga City, and is located on the slopes of Andong Mountain. In themidst of busy farming and farming, the community preserves traditional arts and cultureas one of the most intense activities involved. In order to carry out these artistic activities,they use spaces around the residential area as ritual paths, each of which has differentfunctions, meanings and philosophies. The research method used is a QualitativeMethod with a Rationalistic approach. Along with the rapid development of the region,the interests of the people and traditional settlements began to erode with forms ofmodernity, which if not restricted would change the character of the region. For thisreason, the study seeks to examine the spatial concepts and structures of traditionalDusun Mantran Wetan residential houses to limit regional development which leads tothe loss of traditional values. The dominance of traditional buildings in Mantran Wetan isformed from several aspects such as the shape of the roof, layout, decoration and othersupporting elements.Keywo rds: mantran wetan, spatial pattern, structure, traditional house.ABSTRAKDusun Mantran Wetan berada pada wilayah administrasi Desa GirirejoKecamatan Ngablak Kabupaten Magelang berjarak ± 25 Km dari arah KabupatenMagelang ke arah Kota Salatiga, dan berada pada lereng Gunung Andong. Di sela-selakesibukan bertani dan bercocok tanam, masyarakat melestarikan seni dan budayatradisional sebagai salah satu aktivitas yang sukup kental digeluti. Dalam rangkamelakukan kegiatan kesenian tersebut, mereka memanfaatkan ruang-ruang di sekitarkawasan permukiman sebagai jalur ritual yang masing-masing memiliki fungsi, maknadan filosofi yang berbeda-beda. Metode penelitian yang dipergunakan adalah MetodeKualitatif dengan pendekatan Rasionalistik. Seiring dengan perkembangan kawasanyang begitu cepat, kepentingan masyarakat dan permukiman tradisional ini mulaitergerus dengan bentuk-bentuk modernitas, yang jika tidak dibatasi akan merubahkarakter kawasan. Untuk itu penelitian ini berupaya untuk mengkaji konsep tata ruangdan struktur rumah tinggal tradisional Dusun Mantran Wetan untuk membatasiperkembangan kawasan yang mengarah kepada hilangnya nilai-nilai tradisional yangada. Dominasi bangunan tradisional di Dusun Mantran Wetan terbentuk dari beberapaaspek seperti bentuk atap, tata ruang, ragam hias dan elemen penunjang lainnya
PENINGKATAN KOMITMEN ORGANISASI MELALUI PENGEMBANGAN BUDAYA ORGANISASI DAN KEPUASAN KERJA
Authors: Rahmanendra Dwi , Suhardi Eka
Published: October 2019

Penelitian ini bertujuan untuk menemukan upaya-upaya yang dapat dilakukan dalam rangka meningkatkan komitmen organisasi Widyaiswara KLHK melalui kajian terhadap hubungannya dengan budaya organisasi dan kepuasan kerja. Populasi penelitian berjumlah 133 widyaiswara yang sedang bertugas aktif di Lembaga Diklat Lingkup Kementerian LHK, dengan jumlah sampel sebanyak 100 orang, yang penentuannya menggunakan rumus Slovin dengan toleransi kesalahan sebesar 5%. Data dikumpulkan menggunakan instrumen dalam bentuk kuesioner dan dianalisis dengan analisis statistik deskriptif dan inferensial. Hasil penelitian menunjukkan tiga hubungan yang positif dan signikan. Pertama, terdapat hubungan yang positif dan signifikan antara budaya organisasi dengan komitmen organisasi Widyaiswara KLHK dengan nilai koefisien korelasi sebesar 0,779. Kedua, terdapat hubungan yang positif dan signifikan antara kepuasan kerja dengan komitmen organisasi Widyaiswara KLHK dengan nilai koefisien korelasi sebesar 0,640. Ketiga, terdapat huhungan yang positif dan signifikan antara budaya organisasi dan kepuasan kerja secara bersama-sama dengan komitmen organisasi Widyaiswara KLHK dengan nilai koefisien korelasi sebesar 0,802. Kata Kunci : Budaya Organisasi, Kepuasan Kerja, Komitmen Organisasi.
PEMANFAATAN E-BOOK KONSEP ASAM BASA DALAM PEMBELAJARAN KIMIA UNTUK MENINGKATKAN LITERASI KIMIA SISWA SMA KELAS XI
Authors: Yulianti Rd. Nia Elisa , Permanasari Anna , Heliawati Leny
Published: October 2019

Penelitian ini bertujuan untuk memperoleh informasi tentang pemanfaatan e-book dalam meningkatkan literasi kimia siswa pada materi asam basa. Dalam penelitian ini digunakan metode pre-eksperimen dengan pre-post test design, disertai dengan analisis deskriptif tentang literasi sains siswa dikaitkan dengan penggunaan e-book sebagai bahan ajar. Subyek penelitian terdiri dari 38 siswa kelas XI dari satu SMA di daerah Bogor, Jawa Barat, dan 3 guru kimia. Instrumen yang digunakan dalam penelitian ini terdiri dari tes literasi dan angket respon siswa serta guru. Hasil penelitian menunjukkan bahwa penggunaan e-book asam basa dapat meningkatkan minat siswa yang dibuktikan dari hasil tanggapan siswa. Hampir semua siswa menyatakan sangat menyenangi e-book, dan merasakan manfaatnya dalam belajar asam-basa, Guru juga memberikan respon yang sangat baik, 87% guru menyatakan bahwa e-book asam-basa sangat memudahkan guru dalam pembelajaran sebagai sumber belajar alternatif. Hasil penelitian lebih lanjut menunjukkan bahwa pemanfaatan e-book dapat meingkatkan literasi sains siswa, dengan peningkatan (Ngain) sebesar 40,2% (kategori sedang).
"Would I Do This All Over Again? Mid-Career Voices in Political Science"
Authors: van Assendelft Laura , Fortna Page , Gay Claudine , Sanbonmatsu Kira
Published: October 2019

This report by the APSA Presidential Task Force on Women’s Advancement in the Profession is based on personal and confidential semi-structured interviews with individuals from three graduate programs who entered graduate school around the same time (the early 1990s) about their educational and career experiences from the decision to pursue the PhD to the present—regardless of whether or not the individuals completed the degree or work in the profession today. How do people experience the profession of political science? What explains differences in individual trajectories—both within and outside the academy? How do climate, efforts to diversify the academy, and policies such as family leave impact individual careers? What policies and practices help graduate students on the job market, and faculty on the tenure-track? What are the tradeoffs in academic and non-academic pursuits? And what is the value of the Ph.D.—inside and outside the academy?
The human right to work: The tension between intrinsic and instrumental values in five teachers’ stories from the industrial technology programme
Authors: Asghari Hamid , Schaffar-Kronqvist Birgit
Published: October 2019

In this article, we discuss a tension between the intrinsic and instrumental value in relation to work and human life. This tension is reflected in the UN Declaration of Human Rights, which regards work as an intrinsic value for a human life, as well as in the (neoliberal) labour market, that values work and workers for their instrumental ends. In the light of this tension, we analyse how five vocational teachers’ life stories express it through descriptions of their experiences, decisions and teaching. The methodological starting point of our study is based on a narrative perspective, where vocational teachers’ stories are at the centre. Our analytical tools are taken from Bamberg (1997), who discusses how people position themselves in their own stories. In light of four positions as outlined by Bamberg, we discuss three tensions: 1) The right to work as universal and under conditions at the same time, 2) Work as a place for belonging under the shadow that only profit counts, and 3) Performing a good job, while balancing professional pride and the concern for oneself. In our conclusions, we suggest that vocational teachers should provide their students with wider civic knowledge about their rights as well as about possible forms of influencing structures in the labour market that vocational teachers are in part preparing their students for.
Biostimulants for Plant Growth Promotion and Sustainable Management of Phytoparasitic Nematodes in Vegetable Crops
Authors: D’Addabbo Trifone , Laquale Sebastiano , Perniola Michele , Candido Vincenzo
Published: October 2019

The parasitism of root-knot nematodes, Meloidogyne spp., can cause heavy yield losses to vegetable crops. Plant biostimulants are often reported for a side-suppressive effect on these pests and many commercial products are increasingly included in sustainable nematode control strategies. Source materials of most biostimulants derived from plant or seaweed raw materials were documented for a reliable suppression of root-knot nematode species, whereas the suppressiveness of microbial biostimulants was found largely variable, as related to the crop and to environmental factors. Chitosan-based biostimulants were also stated for a variable phytonematode suppression, though clearly demonstrated only by a few number of studies. In a preliminary experimental case study, four commercial biostimulants based on quillay extract (QE), sesame oil (SO), seaweeds (SE), or neem seed cake (NC) were comparatively investigated for their effects against the root-knot nematode M. incognita on potted tomato. Soil treatments with all the four biostimulants resulted in a significant reduction of nematode eggs and galls on tomato roots, though NC and SO were significantly more suppressive than QE or SE. In addition, almost all biostimulant treatments also resulted in a significant improvement of tomato growth compared to the non-treated control. These preliminary results seem to confirm the literature data and clearly indicate the potential role of biostimulants for a safe nematode management both in organic and integrated crop systems.
Phenolics and Carotenoid Contents in the Leaves of Different Organic and Conventional Raspberry (Rubus idaeus L.) Cultivars and Their In Vitro Activity
Authors: Ponder Alicja , Hallmann Ewelina
Published: October 2019

Raspberry leaves are a source of carotenoids and polyphenols, including ellagic acid and salicylic acid. The results of scientific research suggest that they have potential pro-health properties that contribute to human health. The aim of this study was to determine the polyphenolic and carotenoid profiles in the leaves of selected raspberry cultivars and their in vitro activity. The second aim was to determine the impact of organic and conventional farm management on the polyphenol, carotenoid, and chlorophyll contents in different raspberry cultivars: ‘Polana’, ‘Polka’, ‘Tulameen’, ‘Laszka’ and ‘Glen Ample’. Compared with conventional raspberry leaves, organic raspberry leaves were characterized by a significantly higher content of dry matter, total polyphenols, total phenolic acids, chlorogenic acid, caffeic acid, salicylic acid and quercetin-3-O-rutinoside; moreover, the organic leaves were characterized by higher antioxidant activity. Among examined cultivars, ‘Polka’ c. was characterized by the highest antioxidant status. However, raspberry leaves from conventional farms contained more total carotenoids, violaxanthin, alpha-carotene, beta-carotene, total chlorophyll and individual forms of chlorophylls: a and b.
An Analysis of Mechanical Properties for Ultrasonically Welded Multiple C1220-Al1050 Layers
Authors: Kim Jisun , Kim Jaewoong , Kim In-ju , Kang Sungwook , Chun Kwangsan
Published: October 2019

This study analyzed the characteristics of aluminum and copper sheets under multi-layer ultrasonic welding, and observed the strength, fracture type, and interface of the weld zone according to location. In addition, an experimental plan was developed using the Taguchi method to optimize the quadruple lap ultrasonic welding process conditions of 0.4t aluminum and copper sheets, and the experiment was performed for each of 25 welding condition. For strength evaluation, the ultrasonic welding performance was evaluated by measuring the tensile strength as a composite material and the shear force at the weld interface through two types of tensile tests: simultaneous tensile and individual tensile. To identify the individual shear strengths of the multi-layer dissimilar ultrasonic welds, three types of tensile tests were performed for each specimen depending on the location of the welded, and as the distance from the horn increased, each of shear strength decreased while the difference in strength value increased. For quadruple lap welding of pure aluminum and copper sheets, the S/N (Signal to Noise Ratio) was the highest at 64.48 with a coarse-grain pattern and optimal welding conditions, and this was selected as the optimal condition. To evaluate the optimized welding condition, additional tests were conducted using the welding conditions that showed the maximum strength values and the welding conditions optimized using the Taguchi method through simple tests. A strength evaluation of the optimized weldment was performed, and for a simultaneous tensile test, it was found that the strength of the optimized weldment was improved by 45% compared to other cases.
Can One Define the Conductance of Amino Acids?
Authors: Zotti Linda A. , Bednarz Beatrice , Hurtado-Gallego Juan , Cabosart Damien , Rubio-Bollinger Gabino , Agrait Nicolas , van der Zant Herre S.J.
Published: October 2019

We studied the electron-transport properties of ten different amino acids and one dimer (di-methionine) using the mechanically controlled break-junction (MCBJ) technique. For methionine and cysteine, additional measurements were performed with the scanning tunneling microscope break-junction (STM-BJ) technique. By means of a statistical clustering technique, we identified several conductance groups for each of the molecules considered. Ab initio calculations revealed that the observed broad conductance distribution stems from the possibility of various binding geometries which can be formed during stretching combined with a multitude of possible conformational changes. The results suggest that it would be helpful to explore different experimental techniques such as recognition tunneling and conditions to help identify the nature of amino-acid-based junctions even further, for example, with the goal to establish a firm platform for their unambiguous recognition by tunneling break-junction experiments.
In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon
Authors: Kitagawa Daniel , Cavalcante Samir , de Paula Reuel , Rodrigues Rafael , Bernardo Leandro , da Silva Munique , da Silva Thiago , dos Santos Wellington , Granjeiro José , de Almeida Joyce , Barcellos Marcos , de A. Correa Ana , França Tanos , Kuča Kamil , Simas Alessandro
Published: October 2019

Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with nerve agents. Pyridinium oximes are the only clinically available antidotes against poisoning by these substances, but their poor penetration into the blood-brain barrier hampers the efficient enzyme reactivation at the central nervous system. In searching for structural factors that may be explored in future SAR studies, we evaluated neutral aryloximes as reactivators for paraoxon-inhibited Electrophorus eel acetylcholinesterase. Our findings may result into lead compounds, useful for development of more active compounds for emergencies and supportive care.
Health-Related Quality of Life in Adrenocortical Carcinoma
Authors: Steenaard Rebecca V. , Michon Laura A. , Haak Harm R.
Published: October 2019

Insight into the health-related quality of life (HRQoL) impact of adrenocortical carcinoma (ACC) is important. The disease and its treatment options potentially have an impact on HRQoL. For patients with limited survival, HRQoL research is of utmost importance. We will therefore provide an overview of HRQoL studies in patients with ACC. We found six studies that measured HRQoL in 323 patients with ACC (3 cross-sectional, 1 cohort, 2 trials), all indicating a reduced HRQoL compared to the general population. The FIRMACT trial found that HRQoL of patients with ACC was reduced compared to the general population, and that chemotherapy-mitotane further reduced HRQoL even though survival improved. Clinical aspects of the disease, including cortisol and aldosterone production and adrenal insufficiency have shown great impact on HRQoL in benign disease, even after the recovery of hormonal status. However, the impact of malignant adrenal disease and treatment options on HRQoL including adrenalectomy, radiotherapy, mitotane therapy, and chemotherapy have not been sufficiently studied in patients with ACC. Although the number of HRQoL studies in patients with ACC is limited, the existing literature does indicate that ACC has a large impact on patients’ HRQoL, with disease specific aspects. Further HRQoL research in patients with ACC is essential to improve patient-centered care, preferably by using an ACC-specific HRQoL questionnaire.
Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells
Authors: Wojtala Martyna , Dąbek Arkadiusz , Rybaczek Dorota , Śliwińska Agnieszka , Świderska Ewa , Słapek Katarzyna , El-Osta Assam , Balcerczyk Aneta
Published: October 2019

The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that can demethylate mono- and dimethylated histone lysines 4 and 9 (H3K4 and H3K9). The removal of methyl groups from the lysine residues of histone and non-histone proteins was found to be an important regulatory factor of cell proliferation. However, its role has not been fully elucidated. In this study, we assessed LSD1-mediated cell cycle progression using a human endothelial cell model. The short hairpin RNA knockdown of LSD1 inhibits the G2/M phase of cell cycle progression by checkpoint kinase 1 (Chk1) phosphorylation (S137). We observed elevated DNA damage, which was consistent with the increased detection of double-strand breaks as well as purines and pyrimidines oxidation, which accompanied the activation of ATR/ATRIP signaling by H2AXS139 phosphorylation. The irreversible pharmacological inhibition of LSD1 by 2-phenylcyclopropylamine (2-PCPA) inactivated its enzymatic activity, causing significant changes in heterochromatin and euchromatin conformation assessed by chromatin assembly factor 1 subunit A (CAF1A) and heterochromatin protein 1 isoform α and γ (HP1α/γ) immunofluorescence analysis. We conclude that the knockdown of LSD1 in endothelial cells leads to increased HP1-positive chromatin, the stimulation of DNA repair processes, and the dysregulation of proliferation machinery.
Cellular Processing of the ABCG2 Transporter—Potential Effects on Gout and Drug Metabolism
Authors: Mózner Orsolya , Bartos Zsuzsa , Zámbó Boglárka , Homolya László , Hegedűs Tamás , Sarkadi Balázs
Published: October 2019

The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells. Variants of the ABCG2 transporter, affecting cellular processing and trafficking, have been shown to cause gout and increased drug toxicity. In this paper, we overview the key cellular pathways involved in the processing and trafficking of large membrane proteins, focusing on ABC transporters. We discuss the information available for disease-causing polymorphic variants and selected mutations of ABCG2, causing increased degradation and impaired travelling of the transporter to the plasma membrane. In addition, we provide a detailed in silico analysis of an as yet unrecognized loop region of the ABCG2 protein, in which a recently discovered mutation may actually promote ABCG2 membrane expression. We suggest that post-translational modifications in this unstructured loop at the cytoplasmic surface of the protein may have special influence on ABCG2 processing and trafficking.
The Aquatic Organisms Diversity, Community Structure, and Environmental Conditions
Authors: Protasov Alexander , Barinova Sophia , Novoselova Tatiana , Sylaieva Anzhelika
Published: October 2019

Two main aspects of the study of diversity can be distinguished: the first is related to the inventory of living organisms, the second is related to the organization of life at the level of biotic communities. Quantitative assessment of diversity is two-components as the richness of elements and their evenness. A model of the ecosystem continuum is proposed. The greatest indicators of diversity should be expected in the middle part of the environmental gradients with temporal stability. Study of producers and consumers in water bodies of Ukraine showed a regular change in their community structure in the gradient of saprobity indices. The decreasing of community diversity estimated by the Shannon index and by species richness was found at both high and low values of the saprobity indices. The fundamental coincidence of the empirical point fields of the Shannon index for the communities of invertebrates and phytoplankton with the field points of the empirical model indicates the universality of the bimodal distribution of diversity indicators in the trophic gradient. It is shown that the estimates by zoobenthos overestimate organic pollution compared with the calculations of the same indicators by phytoplankton.
Hyperscaling Violation in Ising Spin Glasses
Authors: Campbell Ian A. , Lundow Per H.
Published: October 2019

In addition to the standard scaling rules relating critical exponents at second order transitions, hyperscaling rules involve the dimension of the model. It is well known that in canonical Ising models hyperscaling rules are modified above the upper critical dimension. It was shown by M. Schwartz in 1991 that hyperscaling can also break down in Ising systems with quenched random interactions; Random Field Ising models, which are in this class, have been intensively studied. Here, numerical Ising Spin Glass data relating the scaling of the normalized Binder cumulant to that of the reduced correlation length are presented for dimensions 3, 4, 5, and 7. Hyperscaling is clearly violated in dimensions 3 and 4, as well as above the upper critical dimension D = 6 . Estimates are obtained for the “violation of hyperscaling exponent” values in the various models.
Detection of Wildfire Smoke Images Based on a Densely Dilated Convolutional Network
Authors: Li Tingting , Zhao Enting , Zhang Junguo , Hu Chunhe
Published: October 2019

Recently, many researchers have attempted to use convolutional neural networks (CNNs) for wildfire smoke detection. However, the application of CNNs in wildfire smoke detection still faces several issues, e.g., the high false-alarm rate of detection and the imbalance of training data. To address these issues, we propose a novel framework integrating conventional methods into CNN for wildfire smoke detection, which consisted of a candidate smoke region segmentation strategy and an advanced network architecture, namely wildfire smoke dilated DenseNet (WSDD-Net). Candidate smoke region segmentation removed the complex backgrounds of the wildfire smoke images. The proposed WSDD-Net achieved multi-scale feature extraction by combining dilated convolutions with dense block. In order to solve the problem of the dataset imbalance, an improved cross entropy loss function, namely balanced cross entropy (BCE), was used instead of the original cross entropy loss function in the training process. The proposed WSDD-Net was evaluated according to two smoke datasets, i.e., WS and Yuan, and achieved a high AR (99.20%) and a low FAR (0.24%). The experimental results demonstrated that the proposed framework had better detection capabilities under different negative sample interferences.
About Linda Again: How Narratives and Group Reasoning Can Influence Conjunction Fallacy
Authors: Donati Camillo , Guazzini Andrea , Gronchi Giorgio , Smorti Andrea
Published: October 2019

Conjunction fallacy (together with other systematic reasoning errors) is usually explained in terms of the dual process theory of reasoning: Biases should be ascribed to fast and automatic processes, whereas slow and deliberative processes are responsible of producing answers that are correct with respect of normative criterion. The dual process theory is related to Bruner’s distinction between narrative and paradigmatic thought: Both modes of thought can be characterized by the two different processes of reasoning. In this paper, we explore the role of Bruner’s mode of thought manipulating also the difference between group vs individual reasoning. We observed that the narrative strategy of response induces more wrong answers. However, narrative-based strategies have higher effectiveness in the case of group reasoning. Our results suggest that narrative reasoning and group reasoning may induce violations of the conjunction rule when acceptable by the verisimilitude of the story. Five models are also presented in order to predict answer correctness and strategy of reasoning using a text analysis software.
A Trustworthy Communication Hub for Cyber-Physical Systems
Authors: Latvakoski Juhani , Heikkinen Jouni
Published: October 2019

The motivation for this research arises from the challenges in the trustworthy communications related operation of cyber-physical systems (CPS), especially in the energy and mobility domains. The increasing amount of distributed energy resources (DERs) of prosumers and electric vehicles requires new ways for CPS communications to enable information exchanges for smart operation in peak consumption hours and balancing power levels in the energy grids in order to lower the energy cost. The huge number of mobile appliances and the related service providers do not serve properly the privacy of the owners, owing to the vertical silo type of operating model in industries. As the results of this research, we provide a trustworthy communication hub for CPS (CPS hub) for solving the challenges related to trustworthy communications between physical resources owned by different stakeholders. The CPS hub realizes the communication spaces concept, and enables combined trust and communications processes when dynamic resources owned by different stakeholders are exchanging information. The evaluations showed that the provided CPS hub enable information exchanges between distributed energy resources of different stakeholders, so that they can join the aggregation process for more flexible and efficient resource usage in energy markets. The CPS hub enable interaction between heterogeneous physical devices of multiple stakeholders to exchange information so that, for example, authorities can see the situation in the emergency area and, simultaneously, the policies of the owners can be taken into concern. Despite limited evaluation scenarios, it is shown that consideration of the ownership issues in the trustworthy communication for information exchanges between heterogeneous physical resources (devices) is possible and feasible. Several future research items, such as, for example, scalability; real-time and streams based operation; as well as consideration of the security, privacy, trust, and safety challenges, were detected. However, the evaluations showed that the constructed CPS hub contribute a set of very essential technical enablers for future smart CPS systems and create strong a basis for such future research towards a future smart society.
Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A
Authors: Win-Shwe Tin-Tin , Yanagisawa Rie , Koike Eiko , Takano Hirohisa
Published: October 2019

Bisphenol A (BPA) is a major constituent of plastic products, including epoxy resin containers, mobile phones, dental sealants, as well as electronic and medical equipment. BPA is recognized as an endocrine system-disrupting chemical which has toxic effects on the brain and reproductive system. However, little is known about the effects of co-exposure of BPA with allergens on the memory function and neurological as well as immunological biomarker levels. In this study, we examined the effects of intratracheal instillation of BPA on the memory function and neuroimmune biomarker levels using a mouse model of allergic asthma. Male C3H/HeJ Jcl mice were given three doses of BPA (0.0625 pmol, 1.25 pmol, and 25 pmol BPA/animal) intratracheally once a week, and ovalbumin (OVA) intratracheally every other week from 5 to 11 weeks old. At 11 weeks of age, a novel object recognition test was conducted after the final administration of OVA, and the hippocampi and hypothalami of the animals were collected after 24 h. The expression levels of the memory function-related genes N-methyl-D-aspartate (NMDA) receptor subunits, inflammatory cytokines, microglia markers, estrogen receptor-alpha, and oxytocin receptor were examined by real-time RT-PCR (real-time reverse transcription polymerase chain reaction) and immunohistochemical methods. Impairment of the novel object recognition ability was observed in the high-dose BPA-exposed mice with allergic asthma. In addition, the allergic asthmatic mice also showed downregulation of neurological biomarkers, such as NMDA receptor subunit NR2B in the hippocampus but no significant effect on immunological biomarkers in the hypothalamus. These findings suggest that exposure to high-dose BPA triggered impairment of memory function in the allergic asthmatic mice. This is the first study to show that, in the presence of allergens, exposure to high-dose BPA may affect memory by modulating the memory function-related genes in the hippocampus.
Aerobic and Anaerobic Biodegradation of 1,2-Dibromoethane by a Microbial Consortium under Simulated Groundwater Conditions
Authors: Wang Qing , Yang Miaoyan , Song Xin , Tang Shiyue , Yu Lei
Published: October 2019

This study was conducted to explore the potential for 1,2-Dibromoethane (EDB) biodegradation by an acclimated microbial consortium under simulated dynamic groundwater conditions. The enriched EDB-degrading consortium consisted of anaerobic bacteria Desulfovibrio, facultative anaerobe Chromobacterium, and other potential EDB degraders. The results showed that the biodegradation efficiency of EDB was more than 61% at 15 °C, and the EDB biodegradation can be best described by the apparent pseudo-first-order kinetics. EDB biodegradation occurred at a relatively broad range of initial dissolved oxygen (DO) from 1.2 to 5.1 mg/L, indicating that the microbial consortium had a strong ability to adapt. The addition of 40 mg/L of rhamnolipid and 0.3 mM of sodium lactate increased the biodegradation. A two-phase biodegradation scheme was proposed for the EDB biodegradation in this study: an aerobic biodegradation to carbon dioxide and an anaerobic biodegradation via a two-electron transfer pathway of dihaloelimination. To our knowledge, this is the first study that reported EDB biodegradation by an acclimated consortium under both aerobic and anaerobic conditions, a dynamic DO condition often encountered during enhanced biodegradation of EDB in the field.
Interferon-Inducible Protein 10 and Disease Activity in Systemic Lupus Erythematosus and Lupus Nephritis: A Systematic Review and Meta-Analysis
Authors: Puapatanakul Pongpratch , Chansritrakul Sonchai , Susantitaphong Paweena , Ueaphongsukkit Thornthun , Eiam-Ong Somchai , Praditpornsilpa Kearkiat , Kittanamongkolchai Wonngarm , Avihingsanon Yingyos
Published: October 2019

There is increasing evidence of a correlation between interferon-inducible protein 10 (IP-10) and disease activity of systemic lupus erythematosus (SLE) and lupus nephritis (LN). We conducted a comprehensive search on IP-10 using MEDLINE, Scopus, and Cochrane electronic databases from the beginning to the end of December 2017. All studies that compared serum and/or urine IP-10 between active SLE/LN patients and any control groups were identified and included in this systematic review and meta-analysis. The mean difference (MD) of IP-10 level among active SLE and LN patients, as well as the correlation of IP-10 with disease activity, were meta-analyzed using a random-effects model. From 23 eligible studies, 15 provided adequate data for meta-analysis. Serum IP-10 was significantly elevated in patients with active SLE compared to non-active SLE patients (MD 356.5 pg/mL, 95% CI 59.6 to 653.4, p = 0.019). On the other hand, the levels of serum IP-10 was not different between active LN and non-active LN. However, serum IP-10 was positively correlated with disease activity like SLE disease activity index (SLEDAI) (pooled r = 0.29, 95% CI 0.22 to 0.35, p < 0.001). Furthermore, urine IP-10 tended to be higher in patients with active LN compared to non-active LN patients but this did not reach statistical significance (MD 3.47 pg/mgCr × 100, 95% CI −0.18 to 7.12, p = 0.06). Nevertheless, urine IP-10 was positively correlated with renal SLEDAI (pooled r = 0.29, 95% CI 0.05 to 0.50, p = 0.019). In conclusion, serum and urine IP-10 levels may be useful in monitoring the disease activity of SLE and LN. Serum IP-10 was correlated with systemic disease whereas urine IP-10 was a useful biomarker for detecting active LN.
Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing
Authors: Billard Pauline , Poncet Delphine A
Published: October 2019

Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the origin of two of these stresses, namely mitochondrial metabolic compromise, associated with reactive oxygen species (ROS) production, and replicative senescence, activated by extreme telomere shortening. We discuss how replication stress-induced DNA damage of telomeric DNA (telDNA) and mitochondrial DNA (mtDNA) can be considered a common origin of senescence in vitro, with consequences on ageing in vivo. Unexpectedly, mtDNA and telDNA share common features indicative of a high degree of replicative stress, such as G-quadruplexes, D-loops, RNA:DNA heteroduplexes, epigenetic marks, or supercoiling. To avoid these stresses, both compartments use similar enzymatic strategies involving, for instance, endonucleases, topoisomerases, helicases, or primases. Surprisingly, many of these replication helpers are active at both telDNA and mtDNA (e.g., RNAse H1, FEN1, DNA2, RecQ helicases, Top2α, Top2β, TOP3A, DNMT1/3a/3b, SIRT1). In addition, specialized telomeric proteins, such as TERT (telomerase reverse transcriptase) and TERC (telomerase RNA component), or TIN2 (shelterin complex), shuttle from telomeres to mitochondria, and, by doing so, modulate mitochondrial metabolism and the production of ROS, in a feedback manner. Hence, mitochondria and telomeres use common weapons and cooperate to resist/prevent replication stresses, otherwise producing common consequences, namely senescence and ageing.
Generalized Mean-Reverting 4/2 Factor Model
Authors: Cheng Yuyang , Escobar-Anel Marcos , Gong Zhenxian
Published: October 2019

This paper proposes and investigates a multivariate 4/2 Factor Model. The name 4/2 comes from the superposition of a CIR term and a 3/2-model component. Our model goes multidimensional along the lines of a principal component and factor covariance decomposition. We find conditions for well-defined changes of measure and we also find two key characteristic functions in closed-form, which help with pricing and risk measure calculations. In a numerical example, we demonstrate the significant impact of the newly added 3/2 component (parameter b) and the common factor (a), both with respect to changes on the implied volatility surface (up to 100%) and on two risk measures: value at risk and expected shortfall where an increase of up to 29% was detected.