bluuebunny/crossref_metadata_2025 huggingface dataset:
Outlines of the Science and Technology System: A Look into the Past for Forming Policy for the Development of the Next Generation Ecosystem. Part 2
Authors: Aryngazin Askar
Published: March 2024

Shifting from the description of landscape of the science and education system presented in the first part of the work as well as from identification of some values of the governing body (all these are needed for a situational study of trends, strengths and weaknesses), in this article we examine the system in a country case to find measures to overcome its accompanying nature with respect to economy. This is manifested in the diversion of management from what researchers and developers do, what they need, where and what goals to set, how to use the results obtained in the field of science and technology for the benefit of society, economy and person. By connecting the system to key building blocks, as well as functions and values they deliver, of a much broader innovation ecosystem, we are setting its next-generation outlines on the agenda. Systematic implementation of policies is based on a long-term vision, strategy and medium-term plans in the field of science, technology and innovation. Strategic decision-making requires greater clarity of the outlines of the future as a professional, and not just a political, consensus of stakeholders. To this end, taking into account the significantly increased pace and changed mechanism of technological renewal which have an impact on competitiveness, we use the method proposed by Startup Genome for ranking startup ecosystems. This method also identifies four stages of the ecosystem life cycle: activation, globalization, attractiveness and integration. We rely on concepts, historical and current practical examples to give high-level characteristics and formulate criteria and tasks for transformation of the startup ecosystem as a part of innovation ecosystem.
Towards a Sociological Understanding of Human Capital in a Fluid Society in a State of Crisis
Authors: Popov Dmitry , Shestakova Daria
Published: March 2024

The importance of human capital and human development for understanding economics and social relations has repeatedly been proven since the time of Adam Smith. Theories on human capital and human development were conceptualized in their modern form in the USA in the 1960’s to 1980’s. However, in recent decades they have been seriously criticized in scientific literature, primarily due to issues pertaining to how they approach measurement. In this article a critical revision of the main approaches towards evaluating human capital in modern social sciences is conducted. New strategies for measuring human capital and human development include not only a “quantitative” indicator (number of years spent receiving formal education), but also an indicator showing the quality of acquired knowledge and skills. Such approaches provide a possibility to observe the improvement or degradation of human capital outside of conventional formal education, which allows perceiving human capital as embedded in the processes of local social, economic and historical development. This historical rootedness of human capital and human development seems to be of utmost importance for fluid societies in a state of crisis. The prospects for sociologization of the concepts of human capital and human development as well as the potential of life-course sociology for their analysis are discussed. It is suggested to view human capital through a cohort approach lens. The discussion outlines research strategies for studying human capital and human development within the proposed logic.
Pelaksanaan Program PIK R dan Dampaknya bagi Remaja, Studi Deskriptif di Kampung Keluarga Berencana (KB) Desa Sukoreno Kecamatan Kalisat Kabupaten Jember
Authors: Putri Glori Cahya
Published: March 2024

Research is to describe the implementation of the Youth Information and Counseling Center (PIK R) program and its impact on youth. The PIK R program is one of several programs implemented by the Family Planning Village (KB) of Sukoreno Village, Kalisat District, Jember Regency. The government provides PIK R programs for adolescents to practice life skills and develop the quality of adolescents. The problem is how to implement the PIK R program and its impact on adolescents. The research method uses a qualitative approach. Purposive determination of informants. Data collection by interview, observation and documentation. After the data collected is analyzed and tested its validity. The results showed that the implementation of the PIK R program were: Peer Educator Training and Peer Counselors namely training for PIK R youth related to the KRR TRIAD covering sexuality, HIV and AIDS and drugs, Life Skill Activity in catfish cultivation, namely catfish cultivation as a routine activity for teens to improve life skills, Utilization of catfish as catfish nuggets is one of the efforts related to the creativity of PIK R teenagers in managing catfish into more interesting food. Impacts of PIK R for adolescents, namely: Psychological Impacts of changing adolescent bad habits in changing drunken behavior and the use of illegal drugs have now stopped, Social Impact eliminates anxiety for local residents as the environment is a place of influence so that better teenage change will have an impact on around it, Economic Impact helps parents increase family income through catfish cultivation life skill activities by teenagers PIK R.

Keywords: PIK R, Impact, Teenagers
Why Photography Mattered (1847) As Art More Than Ever Before
Authors: Gallus-Price Sibyl
Published: March 2024

In the late 20th-century, landscape photographs that were never meant as art come to play a central role in the critique of one notion of what art is. Rosalind Krauss begins her attack on Modernism by mobilizing the indexical qualities of the photograph, holding up Timothy O’Sullivan’s 19th-century landscape photographs as the exemplar. This essay considers Krauss’s model in relation to César Aira’s contemporary revival of the 19th century landscape painter Johann Moritz Rugendas who is conceived, I argue, under the sign of the photograph. Conceptually recasting the landscape— the locus classicus for the crisis of Modernist art— through Rugendas, Aira transforms the painterly genre into an alternative neuro-aesthetically charged “procedure.” Aira’ s landscape painter turned photographer serves, I contend, both as an emblem for Aira’s own relation to writing and as an artifact of Krauss’s post-Art world.
A metaelemzés lépéseinek bemutatása : Cohen-féle d hatásnagyság alapú elemzés egymintás kontextusban
Authors: Czine Péter , Török Áron , Maró Gréta
Published: March 2024

A tanulmány célja, hogy bemutassa a metaelemzés főbb lépéseit a Cohen-féle d hatásnagyság-mutató egymintás kontextusban történő alkalmazásakor. A szerzők egy valós felmérés adatbázisát használják fel példaként, amelyen keresztül ismertetik az elemzéshez szükséges adatbázis felépítését, az overall hatásnagyság-mutató meghatározásának lépéseit, az eredmények értelmezését és a vizsgált cikkek közötti heterogenitás magyarázatának egy lehetséges megközelítését (alcsoportelemzés). Habár jelen tanulmány viszonylag egyszerű struktúrában ismerteti a módszer alkalmazásának főbb lépéseit, mindössze a Cohen-féle d hatásnagyságra alapozott, egymintás kontextusban történő elemzésre koncentrál. Fontos kiemelni, hogy kutatási kérdéstől függően más-más hatásnagyság-mutatókkal kell kalkulálni, illetve az elemzés komplexitása is sokkal jobban elmélyíthető.
O texto artístico, o contexto e o intertexto na elaboração de índices temáticos de séries artístico-pictóricas
Authors: Medeiros Wagner Oliveira de , Pinho Fabio Assis
Published: March 2024

Introdução: As séries artístico-pictóricas são um tipo de documento com particularidades informativas que enviezam novos caminhos para atividades de representação. Suscitam a valorização de uma abordagem sociocognitiva que respeite as particularidades culturais da produção documental nos campos de Arte e Cultura. Objetivo: Apresentar a indexação e a elaboração do índice temático da série artístico-pictórica “Linguagem do Agreste”, do artista plástico pernambucano Joaz Silva. O índice em questão foi desenvolvido para fins de representação das informações oriundas das narrativas visuais com valor memorialístico e de caráter contextual de produção da série. Deste modo, trazem-se inferências sobre o processo de indexação realizado, discutindo sobre o texto artístico, a intertextualidade e o caráter contextual que circundam a dimensão sociocognitiva deste processo documentário. Metodologia: Apresenta-se um estudo de caso de abordagem qualitativa e caráter exploratório e interdisciplinar entre os campos da Ciência da Informação e das Artes. Resultados: Apresenta as etapas de análise documental, processamento dos resultados da análise documental e a estruturação do índice temático. Conclusão: A discussão interdisciplinar estabelecida amplia e oportuniza as discussões da Ciência da Informação sobre os documentos artísticos. A elaboração de índices temáticos é uma contribuição social para as artes e para os artistas, servindo como material de consulta e de referência para a indexação de séries artístico-pictóricas e para a comunidade de pesquisadores, como fonte de informação e consulta.
Assessment of the prevention and problem solving of drug problem with participation in schools under the local administrative organization in Sisaket province
Authors: Phuttanu Vivat , Cain Parisha Marie , Kaewhanam Kathanyoo , Kaewhanam Phimlikid
Published: March 2024

The objectives of this research were (1) to assess the suitability and feasibility of participatory approaches for the prevention and solution of drug problems of schools under Sisaket Provincial Administrative Organizations and (2) to create a consensus proposing a leadership development model that influences driving effectiveness, management and performance on drug prevention of schools under the local government organization. The informants were the study administrators and teachers who were responsible for prevention and correction drug problem of school, each group of 5 people, and the total of 10 people, obtained by purposive selection. The research instrument was a semi-structured interview. The interviews were conducted during January to March 2023. The research results showed that (1) Participatory approaches for the prevention and solution of drug problems of schools under the local administrative organizations in Sisaket Province of every created item had a suitability assessment at a level higher than the specified criteria and the possibility of implementing the guidelines; and (2) leadership development model that influences management and results of drug prevention operations in schools under the local government organization can be summarized in 5 issues: (1) raising awareness and education (2) developing communication skills (3) building trusted teams (4) being a good role model, and (5) self-reflection and assessment.
Progression of liver disease and associated risk of hepatocellular carcinoma
Authors: Poli Edoardo , De Martin Eleonora
Published: March 2024

Hepatocellular carcinoma (HCC) is the primary liver cancer type, often seen in individuals with chronic liver disease. Once the patient progresses to the cirrhotic stage, the annual incidence of HCC is approximately 2%-4%. As it exceeds the minimum threshold of 1.0%-1.5% per year, HCC screening every 6 months through abdominal ultrasound is indicated in the cirrhotic population. While the incidence of viral hepatitis-associated HCC is decreasing, there is a notable rise of HCC associated with metabolic dysfunction-related steatotic liver disease and alcohol-related liver disease, particularly in high-income countries. The most effective approach for oncological prevention remains addressing the cause of liver disease. The indications for HCC screening in patients without cirrhosis depend on the etiology of liver disease and the stage of fibrosis, assessed by liver biopsy or noninvasive tests such as FIB-4 or transient elastography. However, clear recommendations for HCC screening in patients without cirrhosis and for the different etiologies are currently unavailable. Research efforts should focus on identifying markers, or combinations thereof, to provide a more accurate estimate of HCC occurrence. Such advancements would enable the effective targeting of populations at the highest risk of HCC and the establishment of the correct timing to start the screening.
Модель банковской системы России с разбивкой по срочности основных категорий активов и пассивов
Authors: Pil'nik Nikolay Petrovich , Radionov Stanislav Andreevich
Published: March 2024

Представлена новая версия модели банковской системы России, описывающая динамику широкого набора показателей банковской деятельности. По сравнению с предыдущей версией модели добавлена разбивка по срочности объемов кредитов и депозитов фирм и домохозяйств в рублях. Показано, что модель позволяет с высокой точностью воспроизводить широкий набор показателей деятельности банковской системы России, превосходя эконометрические аналоги для большинства переменных.
Сопряженная модель для интерактивной симуляции движения парусного судна при воздействии нерегулярного волнения и ветра
Authors: Zheleznyakova A L
Published: March 2024

Разработка интерактивных сопряженных моделей динамики плавающих тел, подверженных изменчивым внешним воздействиям ветра и нерегулярного волнения, -- чрезвычайно важная задача. В работе предложен экономичный вычислительный подход, который реализует упрощенные, но физически оправданные модели, интегрированные в единую расчетную среду. В качестве объекта моделирования выбрана реалистичная геометрическая модель парусного судна с рулевым управлением и регулируемыми парусами. Нерегулярные ветровые волны моделируются путем вероятностного описания с использованием быстрого обратного преобразования Фурье на основе данных наблюдений морской поверхности. Сложные конфигурации корабля и объектов на поверхности воды, а также колеблющаяся водная поверхность описываются подробными треугольными сетками. Интегральная модель включает динамику погруженного твердого тела с шестью степенями свободы. В рамках подхода реализован метод расчета ветровых нагрузок на регулируемые паруса произвольной формы, а также на корпус, судовые надстройки, мачты и т.д. Волновой след за движущимся судном, который распространяется и отражается от препятствий, моделируется с использованием линеаризованной теории поверхностных волн в сочетании с операциями двумерной свертки и маскировки, применяемыми к полю высоты волны. Объединение указанных вычислительных технологий в рамках интегрированной модели позволяет проводить сопряженное моделирование динамики корабля, находящегося под воздействием ветра и нерегулярных волн, в режиме реального времени. Скоростные характеристики виртуального корабля сравниваются с экспериментальными полярами скорости реального парусного судна.
Strategi Pengembangan Agrowisata Berbasis Lingkungan di Desa Loto Kecamatan Ternate Barat
Authors: Nasution Lely , Aji Krishna , Rohana Sufia  , Tangge Nurul Ainun
Published: March 2024

Agrowisata Desa Loto di Kecamatan Ternate Barat terletak pada kemiringingan lereng yang cukup curam sehingga berpotensi menyebabkan terjadinya erosi. Penelitian ini bertujuan untuk mengidentifikasi bentuk pengelolaan lingkungan di agrowisata, menganalisis potensi agrowisata serta merumuskan rekomendasi strategi pengembangan untuk agrowisata. Metode penelitian ini menggunakan deskriptif kualitatif. Perolehan data pada penelitian ini dilakukan dengan indepth interview dan observasi untuk memeroleh bentuk pengelolaan lingkungan serta potensi agrowisata. Hasil identifikasi dan analisis tersebut kemudian digunakan sebagai dasar pada perumusan strategi pengembangan agrowisata dengan pendekatan SWOT. Hasil penelitian menunjukkan bahwa bentuk pengelolaan lingkungan di agrowisata Desa Loto dilakukan dengan pembuatan teras kebun yang terbagi menjadi tiga segmen dengan jenis sayuran yang berbeda. Faktor pendukung pada potensi agrowisata terdapat pada partisipasi masyarakat dan kelompok tani dalam mengolah area agrowisata dan faktor penghambat untuk potensi agrowisata Desa Loto terdapat pada kurangnya promosi destinasi tersebut. Berdasarkan hasil analisis SWOT beberapa rumusan rekomendasi untuk pengembangan agrowisata adalah memberikan promosi lebih luas, menyediakan fasilitas memadai, membuka kemitraan dengan pihak swasta, memberikan pendampingan kepada kelompok tani dan masyarakat, mengedukasi cara pengelolaan dan perawatan agrowisata serta memfasilitasi pengembangan untuk hasil produk agrowisata
Pengaruh Gaya Belajar Dan Kecerdasan Intelektual Terhadap Kemampuan Pemahaman Konsep Mata Pelajaran Qur’an Hadist
Authors: Mariska Kristianingrum  , Moh. Miftachul Choiri
Published: March 2024

Tujuan penelitain ini menjelaskan pengaruh yang signifikan antara gaya belajar dan kecerdasan intelektual terhadap kemampuan pemahaman konsep mata pelajaran Qur’an Hadist. Metode penelitian yang digunakan dalam penelitian ini adalah kuantitatif dengan jenis penelitian eks post facto yang bertujuan menemukan penyebab perubahan pada variabel bebas secara keseluruhan. Penelitian ini dilakukan di MI Ma’arif As-Salam Sooko pada kelas III. Cara mengumpulkan data dengan menggunakan angket dengan memberikan kuesioner kepada peserta didik. Sampel yang digunakan dalam penelitian ini sebanyak 45 responden. Uji yang digunakan dalam penelitian ini yaitu uji regresi linier sederhana dan uji regresi linier berganda. Hasil yang diperoleh berupa simpulan gaya belajar memiliki pengaruh yang positif dan signifikan gaya belajar terhadap kemampuan pemahaman konsep memiliki nilai R2 yaitu sebesar 2,1% gaya belajar berpengaruh terhadap kemampuan pemahaman konsep dan sisanya 97,9% dipengaruhi faktor lain yang tidak diteliti oleh peneliti. Kecerdasan intelektual memiliki pengaruh yang positif dan signifikan kecerdasan intelektual terhadap kemampuan pemahaman konsep memiliki nilai R2 sebesar 86,1% kecerdasan intelektual berpengaruh 86,1% terhadap kemampuan pemahaman konsep dan sisanya 13,9% lainnya dipengaruhi oleh faktor lain yang tidak diteliti oleh peneliti. Gaya belajar dan kecerdasan intelektual berpengaruh secara signifikan terhadap kemampuan pemahaman konsep dengan memperoleh nilai R2 yaitu sebesar 86,3% dan sisanya 13,7% lainnya dipengaruhi oleh faktor lain yang tidak diteliti.
Implementasi Kurikulum Merdeka pada Mata Pelajaran IPAS di SDN Sumberdodol 1 Kecamatan Panekan Kabupaten Magetan
Authors: Lailatul Fajar Nurngaini  , Effendi Mukhlison
Published: March 2024

Penelitian ini bertujuan untuk (1) Mendeskripsikan perencanaan kurikulum merdeka pada mata pelajaran IPAS Kelas IV di SDN Sumberdodol 1 Kecamatan Panekan Kabupaten Magetan. (2) Mendeskripsikan pelaksanaan kurikulum merdeka pada mata pelajaran IPAS Kelas IV di SDN Sumberdodol 1 Kecamatan Panekan Kabupaten Magetan. (3) Mendeskripsikan evaluasi kurikulum merdeka pada mata pelajaran IPAS Kelas IV di SDN Sumberdodol 1 Kecamatan Panekan Kabupaten Magetan. Penelitian ini menggunakan metode penelitian kualitatif jenis penelitian studi kasus. Berdasarkan analisis data yang ditemukan bahwa (1) Perencanaan Implementasi Kurikulum Merdeka pada mata pelajaran IPAS di SDN Sumberdodol 1, sudah mengacu pada Kurikulum Merdeka, tetapi belum sempurna. Karena pada Kurikulum Merdeka hanya terdapat 3 dokumen perangkat pembelajaran yang melipui CP, ATP, dan Modul Ajar. Sedangkan di SDN Sumberdodol 1 masih menerapkan program tahunan dan program semester. (2) Pelaksanaan Kurikulum Merdeka pada mata pelajaran IPAS Fase B kelas IV di SDN Sumberdodol 1 guru menerapkan pembelajaran secara langsung dengan pendekatan Contextual Teaching and Learning (CTL). Dimana dalam pembelajaran Kurikulum Merdeka tidak terbatas pada pembelajaran berbasis projek namun juga menyesuaikan materi pembelajaran dan kondisi peserta didik. (3) Evaluasi Implementasi Kurikulum Merdeka pada mata pelajaran IPAS di SDN Sumberdodol 1 yaitu menggunakan penilaian formatif dan sumatif. Yang disesuaikan dengan tujuan dan materi pembelajaran. Tetapi belum melakukan penilaian doagnostik sebelum pembelajaran karena masih transisi antara Kurikulum 2013 dan Kurikulum Merdeka. Maka dapat disimpulkan bahwa SDN Sumberdodol 1 sudah menerapkan kurikulum merdeka, tetapi belum sempurna.
PENGARUH MEDIA PEMBELAJARAN PAPAN DAN KARTU MISTERI TERHADAP KEMAMPUAN BERBICARA SISWA PADA MATA PELAJARAN BAHASA INDONESIA MI MA’ARIF CEKOK, BABADAN, PONOROGO
Authors: Devi Rovi'atus Sholikhah  , Farida Yufarlina Rosita
Published: March 2024

This study aims to prove whether board learning media and mystery cards can be applied as an effort to improve students' speaking skills, the effect of board and mystery cards learning media on students' speaking ability. Using a quantitative approach to the type of experimental research. Data collection in this study used test instruments in the form of pre-test and post-test. Based on the results of data analysis, it was shown that board and mystery card learning media could improve students' speaking skills. This is evidenced by the increased post-test results in the experimental class, and the influence of board and mystery card learning media onstudents' speaking abilities, evidenced by the results of the independent sample t test, which shows t count 8.792 greater than t table 2.02439, and a significance value of 0.000 < 0.05. This means that Ho is rejected and Hi is accepted, so it can be concluded that there is a significant effect of board and mystery cards learning media on students' speaking abilities in the Indonesian language subject MI Ma'arif Cekok, Babadan, Ponorogo.
Meningkatkan Pemahaman Konsep Siswa Melalui Media Buku Diary-Ku Pada Kelas V SDN Sukorejo 1 Kecamatan Rejoso Kabupaten Nganjuk
Authors: Istikakimi
Published: March 2024

Menuliskan kembali konsep yang telah dipelajari merupakan bagian dari aktivitas siswa setelah mengikuti pembelajaran. Tujuan dari penelitian ini yaitu meningkatkan pemahaman konseptual siswa kelas V SDN Sukorejo 1 Kecamatan Rejoso Kabupaten Nganjuk menggunakan media buku diary pada pembelajaran matematika. Desain penelitin yang digunakan yaitu penelitian tindakan kelas dengan tahapan meluputi perencanaan, pelaksanaan tindakan, observasi, dan refleksi. Subjek penelitian kelas V SDN Sukorejo 1 Kecamatan Rejoso Kabupaten Nganjuk berjumlah 25. Teknik pengumpulan data menggunakna tes pemahaman konseptual terdiri dari 15 soal pilihan ganda dan 10 soal uraian. Data yang terkumpul dianalisis menggunakan teknik analisis kualitatif dan kuantitatif. Hasil penelitian menunjukkan adanya peningkatan pemahaman konseptual siswa pada siklus 2 dari 32% menjadi 68%. Berdasarkan hasil penelitian tersebut maka penggunaan media buku diary dapat dikatan efektif dalam meningkatkan pemahaman konseptual siswa di SDN Sukorejo 1 kelas V.
Saudi Aramco Abqaiq Plants Journey in Water Reduction, Reuse, and Sustainability
Authors: Al-Nughairi A.
Published: March 2024

Saudi Aramco Abqaiq Plants’ vision to protect the environment and conserve water is an important target that must be achieved on yearly bases. We aim to reduce the consumption and improve the efficiency, while sustaining these improvements and continuously achieving our results and targets. Our main focus is on the ground water conservation and replacing ground water sources since the region has high water scarcity.

In our water conservation journey, we will start with optimizations and consumption reduction initiatives that involve the least amount of implementation costs. This is achieved by optimizing the available processes and utilizing waste water streams in proper locations and processes. We will begin the reuse initiatives with reusing Reverse Osmosis (RO) reject in many applications, such as using RO reject in multimedia filters backwash, which resulted in 60 Gallon Per Minutes (GPM) reduction in ground water use, while using the RO reject in soft water regen. process resulted in 28 GPM. Other optimization includes cooling tower blowdown cycle of concertation optimization, which resulted in 90 GPM, drinking water optimization (30 GPM), and demineralization plant elimination (100 GPM).

The next initiatives required implementation costs such as cooling towers chemical injection and blowdown automation, which resulted in saving 80 GPM, but this initiative is in progress as there are other cooling towers planned for automation. The next one is Heat Recovery Steam Generators (HRSGs) blowdown reuse in a cooling system (25 GPM).

There are also other optimizations that were originated from procedural changes and resulted in water savings such as sampling practice optimization, steam traps integrity program, skim tanks optimizations, and tube leak early detections.

The total ground water conserved due to the aforementioned initiatives and other water conservation intimins within a four-year period is approximately 900 GPM. Saudi Aramco Abqaiq Plants are still moving forward with new optimizations, initiatives, technology deployments, and finding alternative water resources to save the highest amount possible and reduce our carbon emissions.
Conceptual Selection of Disposal Alternative for Low-Carbon Water Handling Systems
Authors: Al Ismaili S.
Published: March 2024

As part of the ongoing efforts to minimise energy consumption and reduce GHG emissions, PDO has set a new target of eliminating Deep Water Disposal (DWD) practices by 2030, which typically utilise high energy pumps to inject produced water into underground reservoirs without EOR benefit at depths greater than 800 m. This paper aims to identify and assess different water handling alternatives and compare them against DWD for three Gas Assets: S, K and R.

The study comprises the following value drivers: Lower GHG Emissions, Maximize PR Reuse, Minimize LCC, Minimize Deferment Risks, and eliminate DWD. Assured water forecasts were generated from annual business plan activities and converted to water balance figures against the associated sink destinations. Water from each station was analysed for Cation/Anion Analysis, ICP Analysis, OIW Analysis, and NORM analysis. Additionally, power for operating the existing water systems was quantified and projected in tons of CO2e. The alternatives identified for assessment are Algae Treatment, Aquifer Recharge, Agricultural Reuse, Water Injection, Wetland treatment, Evaporation Ponds, and Industrial Salt Production. The requirements for each alternative were recorded.

The high intensity disposal pumps used in the targeted facilities were estimated to contribute to 0.34% of the overall gas assets power demand. The rest of the PW is relocated to neighbouring oil assets to use in water injection for EOR. The quality of water in K and S was found to be very high in salinity and contaminated with NORM by more than double the allowable corporate limit. Whereas R was low in salinity with low NORM (it is processed DM water, and the field is dry). These qualities were compared against the requirements of the alternatives. Upon a high-level screening, the remaining feasible options were evaporation ponds for all facilities and wetlands for R. Further technical and economic analysis was done on the feasible options, and Unit Treatment Costs (UTC) were calculated. K and S were recommended to continue with water disposal, while R was taken forward for wetland options.

This paper provides a useful conceptual methodology for selecting the most suitable alternatives to traditional produced water disposal systems. It provides several options along with their minimum requirements, equipment, pros and cons. Ultimately, this will encourage other operators to consider water management and select low carbon and sustainable solutions.
Evidence for an intermediate mass black hole in a low-mass star-forming galaxy
Authors: Wang Enci , Yao Yao , He Zhicheng , Lin Zheyu , RONG YU , Zhang Hongxin , Kong Xu
Published: March 2024

Intermediate Mass Black Holes (IMBHs) are the bridge of the gap between stellar mass black holes, which are around ten solar masses, and supermassive black holes, which can have millions to billions of solar masses. However, it is still challenging to detect and identify the existence of them with respect to supermassive black holes. We report the evidence of a hidden IMBH for a low-mass galaxy, MaNGA 9885-9102. This galaxy is originally selected from the MaNGA survey with distinctive bipolar Hα blobs at the minor axis. The bipolar feature can be associated with AGN activity, while the two blobs are classified as the HII regions on the BPT diagram, making the origins confusing. The Swift UV continuum shows that the two blobs do not have UV counterparts, suggesting that the source of ionization is out of the blobs. Consistent with this, the detailed photoionization models prefer to AGN rather than star-forming origin with a significance of 5.8σ. The estimated black hole mass is MBH ∼7.2× 105M⊙ from the central velocity dispersion of stars. Not only identifying an active IMBH, this work presents a new method to search for the light echo of IMBH in low-mass and dwarf galaxies of low metallicity, where the traditional BPT diagram fails.
Cervical spinal cord stimulation exerts anti-epileptic effects in a rat model of status epilepticus through the suppression of CCL2-mediated cascades
Authors: Okazaki Yosuke , Sasaki Tatsuya , Hosomoto Kakeru , Tanimoto Shun , Kawai Koji , Nagase Takayuki , Sugahara Chiaki , Yabuno Satoru , Kin Kyohei , Sasada Susumu , Yasuhara Takao , Tanaka Shota , Date Isao
Published: March 2024

Objective
Epidural spinal cord stimulation (SCS) is indicated for the treatment of intractable pain and is widely used in clinical practice. In previous basic research, the therapeutic effects of SCS have been demonstrated for epileptic seizure. However, the mechanism has not yet been elucidated. In this study, we investigated the therapeutic effect of SCS and the mechanism of epileptic seizure.
Methods
First, SCS in the cervical spine was performed. The rats were divided into four groups: control group and treatment groups with SCS conducted at 2, 5, and 300 Hz frequency. Two days later, convulsions were induced by the intraperitoneal administration of kainic acid, followed by video monitoring to assess seizures. We also evaluated glial cells in the hippocampus by fluorescent immunostaining, electroencephalogram measurements, and inflammatory cytokines such as C-C motif chemokine ligand 2 (CCL2) by quantitative real-time polymerase chain reaction.
Results
Seizure frequency and the number of glial cells were significantly lower in the 300 Hz group than in the control group. SCS at 300 Hz decreased gene expression level of CCL2, which induces monocyte migration.
Conclusion
SCS has anti-seizure effects by inhibiting CCL2-mediated cascades. CCL2 and glial cells may be involved in the mechanism of status epilepticus.
The role of vitamin D as a preventive strategy in COVID-19 infections: evidence from South Asia
Authors: Arambepola Carukshi , Seneviratne Ruwanika , Wijeratne Sumedha , Gunawardena Nalika , Wijayamuni Ruwan , Attygalle Deepika
Published: March 2024

Background
Regional evidence on prevention of COVID-19 and its sequalae by vitamin D remains inconclusive and sparse.
Aim/Objective
This study aimed to determine the association between COVID-19 and Vitamin D deficiency among adults in Colombo District, Sri Lanka.
Methods
A sex-matched case-control study was conducted among 104 RT-PCR-confirmed COVID-19 patients and 104 RT-PCR negative adults recruited from community. Non-fasting blood samples were analysed for serum 25(OH)D using chemiluminescence assay and vitamin D deficiency identified (< 50.0nmol/L).
Results
Cases (34.2; SD = 15.4nmol/L) had significantly lower 25(OH)D compared to controls (39.8; SD = 17.8nmol/L) (p = 0.02) which persisted after adjustments (p = 0.02), along with Sinhalese ethnicity (p < 0.001). VDD was significantly more prevalent in cases (83.7% vs. 71.2%; crude odds ratio (OR) = 2.1; 95%-CI:1.1,4.1), although not an independent COVID-19 predictor (adjusted OR = 1.9; 95%-CI:0.6,5.7). A significantly lower 25(OH)D level was observed in moderate/severe cases (39.7; SD = 12.3nmol/L) vs mild (32.9; SD = 15.8nmol/L) (p = 0.015). Neither low serum concentrations nor deficiency showed an independent relationship with severity (p > 0.05). Diabetes was the sole predictor of COVID-19 severity (p = 0.022).
Conclusions
Vitamin D has potential as a cost-effective primary, but not secondary, preventive strategy.
How to accelerate outdoor ageing of perovskite solar cells by indoor testing
Authors: Musiienko Artem , Hartono Noor Titan , Erdil Ulas , Nia Zahra , Khenkin Mark , Köbler Hans , Beckedahl Johannes , Ruske Florian , Schlatmann Rutger , Ulbrich Carolin , Abate Antonio
Published: March 2024

Halide perovskite is a material that shows great promise in producing renewable energy. It offers one of the most efficient forms of photovoltaics for large-scale production. However, while perovskite solar cell devices are more efficient than many established technologies, their long-term stability outdoors is still being determined.

Most studies have tested the stability of perovskite solar cells by keeping them under continuous illumination at maximum power point tracking for hundreds to a few thousand hours. Increasing the temperature has been proposed to accelerate degradation and project data collected relatively quickly to years of outdoor operations. However, PSCs undergo extensive degradation recovery during the resting time in dark and transient dynamics during the illumination they experience in day-night cycling. Therefore, an ageing protocol based on maximum power point tracking under continuous illumination cannot enable quantitative prediction of outdoor performances.

To address the challenge of predicting the outdoor stability of perovskite solar cells, we have demonstrated how ageing perovskite solar cells under light/dark cycling that reproduces outdoor functioning with controlled temperature and illumination conditions allows a predictive analysis. Our ageing protocol can accelerate the degradation of perovskite solar cells up to 46 times, i.e. 6 months of indoor testing can reproduce the standard 25 years of outdoor functioning. This result will speed up the studies of perovskite solar cells' stability and their commercialisation.
Advanced Spatiotemporal Chaos-Based Hash Functions for Enhanced Security
Authors: Li Yuxuan
Published: March 2024

The exploration of spatiotemporal chaos within nonlinear science has attracted significant attention recently. This research unveils an advanced framework for the cross-coupled map lattice, introducing a new spatiotemporal chaotic map. Our experimental assessments show that this refined cross-coupled map lattice outperforms its traditional version in chaotic dynamics. Given the increasing importance of hash functions in cryptography, data integrity verification, and data indexing, our study capitalizes on this innovative spatiotemporal chaos model. We devise a cutting-edge hash function utilizing the enhanced cross-coupled map lattice, capable of converting variable-length input data into fixed-size hash outputs of 128, 256, or 512 bits. Rigorous evaluation against diverse attack scenarios confirms the hash function's security and robustness. Our extensive experimental investigation underscores the hash function's solid security attributes, affirming its aptness for applications requiring stringent data integrity and cryptographic safeguards.
Receptor based study of ethanolic seed extract of Butea frondosa Roxb. Ex. Willd for involvement of cholinergic pathway in regulation with NO signaling to establish a potential anti-trematodal drug against Paramphistomum cervi
Authors: hazarika snigdha , Barua C. C. , Mohan P. , Khargharia S. , Hazorika M. , Tamuly S. , Baruah H. , Borah B. , Konwar P. , Choudhury D.
Published: March 2024

Purpose
Reports were found for traditional use of Butea frondosa Roxb. Ex. Willd for nematode infection but its anti-trematodal property and mechanistic action as an anthelmintic is not yet established. Therefore, present study was conducted to evaluate the same as an anti-trematodal agent.
Methods
Mature and healthy Paramphistomum cervi were collected from the rumen of freshly slaughtered cattle of local abattoir in warm HBSS. For in vitro motility study, six adult P. cervi in each Petri dish having different dilutions of extracts in HBSS ranging from 50, 150, 300, 500, 1000 and 3000 µg/ml and standard Oxyclozanide (10− 5 M) with control receiving only HBSS were taken and incubated at 38 ± 1° C for 5 h. Based on their gross visual motility, ethanolic seed extract of B. frondosa Roxb. Ex. Willd in various concentrations (100, 300, 1000 and 3000 µg/ml) were added to the isometrically mounted P. cervi on isolated tissue bath and their effects on spontaneous muscular activity of P. cervi were estimated.
Results
Ethanolic seed extract of B. frondosa Roxb. Ex. Willd @ 1000 and 3000 µg/ml showed complete death of worms within 1 hr of exposure which was comparable with the standard drug Oxyclozanide @10− 5 M. For neuropharmacological evaluation on isolated tissue bath, ethanolic seed extract of B. frondosa Roxb. Ex. Willd was found to be hyperpolarizing in nature and caused paralysis and death of worms @ 3000 µg/ml.
Predicting Dimensional Antidepressant Response to Repetitive Transcranial Magnetic Stimulation using Pretreatment Resting-state Functional Connectivity
Authors: Wade Benjamin , Barbour Tracy , Ellard Kristen , Camprodon Joan
Published: March 2024

Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression which modulates resting-state functional connectivity (RSFC) of depression-relevant neural circuits. To date, however, few studies have investigated whether individual treatment-related symptom changes are predictable from pretreatment RSFC. We use machine learning to predict dimensional changes in depressive symptoms using pretreatment RSFC. We hypothesized that changes in dimensional depressive symptoms would be predicted more accurately than scale total scores. Patients with depression (n = 26) underwent pretreatment RSFC MRI. Depressive symptoms were assessed with the 17-item Hamilton Depression Rating Scale (HDRS-17). Random forest regression (RFR) models were trained to predict treatment-related symptom changes captured by the HDRS-17, HDRS-6 and three previously identified HDRS subscales: core mood/anhedonia (CMA), somatic disturbances, and insomnia. Changes along the CMA, HDRS-17, and HDRS-6 were predicted significantly above chance, with 9%, 2%, and 2% of out-of-sample outcome variance explained, respectively (all p < 0.01). CMA changes were predicted more accurately than the HDRS-17 (p < 0.05). Higher baseline global connectivity (GC) of default mode network (DMN) subregions and the somatomotor network (SMN) predicted poorer outcomes, while higher GC of the right dorsal attention (DAN) frontoparietal control (FPCN), and visual networks (VN) predicted reduced CMA symptoms. HDRS-17 and HDRS-6 changes were predicted with similar GC patterns. These results suggest that RSFC spanning the DMN, SMN, DAN, FPCN, and VN subregions predict dimensional changes with significantly greater accuracy than syndromal changes following rTMS. These findings highlight the need to assess more granular clinical dimensions in therapeutic studies and echo earlier studies supporting that dimensional outcomes improve model accuracy.
Influence of Dental Status on Postoperative Complications in Major Visceral Surgical and Organ Transplantation Procedures - the BellyDent retrospective observational Study
Authors: Spitzner Anastasia , Mieth Markus , Langan Ewan A , Büchler Markus W , Michalski Christoph , Billmann Franck
Published: March 2024

Background The significance of dental status and oral hygiene on a range of medical conditions is well-recognised. However, the correlation between periodontitis, oral bacterial dysbiosis and visceral surgical outcomes is less well established. To this end, we study sought to determine the influence of dental health and oral hygiene on the rates of postoperative complications following major visceral and transplant surgery in an exploratory, single-center, retrospective, non-interventional study.Methods This investigation was conducted at the Department of General, Visceral, and Transplant Surgery, University Hospital Heidelberg, Germany. Patients were retrospectively enrolled in the study based on inclusion and exclusion criteria. The final patient cohort consisted of 417 patients. A bacteriology examination was added whenever possible for infectious complications.Results There was significant association between oral health and the rate of infectious complications for all surgical procecdures, excluding transplant surgery. However, this did not result in increased 30-day mortality rates, prolonged intensive care unit treatment or an increase in the length of hospital stay (LOS) for the cohort as a whole. In contrast there was a significant correlation between the presence of oral pathogens and postoperative complications for a group as a whole and the visceral surgery subgroup. Whilst this was not the case in the cohort who underwent transplant surgery, there was a correlation between oral health and LOS in this subgroup. Bacterial swabs supports the link between poor oraI health and infectious morbidity.Conclusions Dental status was a significant predictor of postoperative infectious complications in this visceral surgery cohort but not in patient who underwent organ transplantation. The association did not translate into increased mortality rates, extended ICU treatment or increased LOS. This study highlights the importance preoperative dental assessment and treatment prior to major surgery, particularly in the case of elective surgical procedures. Further research is required to determine the effect of oral health on surgical outcomes in order to inform future practice.Trial registration trial registered under the ethics-number S-082/2022 (Ethic Committee of the University Heidelberg).
Number of readmissions and determinants among patients with heart failure at referral hospitals in the Amhara region, Northwest Ethiopia; 2023.
Authors: Gedfew Mihretie , Tesfaye Bekele , Amha Haile , Wondie Tirusew , Gedif Getnet , Getaneh Wodajie , Akalu Tadesse Yirga , Yismaw Lieltework , Diress Gedefaw
Published: March 2024

Aim: This study aimed to determine the number of readmissions among patients with heart failure and identify the determinants of heart failure among patients at referral hospitals in the Amhara region, North western Ethiopia, in 2023.
Study design: A cross-sectional study design was employed using zero-inflated negative binomial models.
Methods: Data were collected from patients with heart failure at referral hospitals in the Amhara region from September 2022 to February 2023. The data were collected from 663 patients with heart failure using chart reviews and interviewer-administered questions.
Results: In this study, 237 (35.7%) patients with heart failure were readmitted at least once. The study showed that for every unit increase in the respiratory rate, the number of readmissions among patients with heart failure increased by 1.5% (IRR=.0.015; 95% CI=0.0004, 0.031), 0.044. In addition, as the duration of medication intake increased by one unit, the number of readmissions increased by 1.1% (IRR. =.0.011: 95% CI: 0.016, 0.051), 0.0001, while keeping all the other model variables constant. Similarly, compared with those of patients with good social support, the number of readmissions of patients with poor social support decreased by 59.4% (IRR=-1.595: 95% CI=-0.02, -0.005), 0.041. On the other hand, when thebody mass index increased by one unit, the odds of being in the always-zero group increased by 11.5% (IRR = 0.115: 95% CI: 0.035, 0.196), 0.004. Moreover, when the pulse rate increased by one unit, the odds of being in the always zero group decreased by 1.27% (IRR = -0.013: 95% CI: -0.025, -0.008), 0.036.
Implications for Clinical Practice: Determining the factors that lead to heart failure (HF) readmission is essential for developing effective interventions to lower the number of readmissions and hospital stays that may negatively impact patients’ and their families' overall socioeconomic status. Additionally, this study provides a baseline for the progress of nursing research and education as well as input for policy makers, all of which will help to improve nursing practice.
Patient or Public Contribution: Improves patients overall quality of care
Exploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop
Authors: Yao Gaosheng , Fu Liangmin , Dai Junshang , Chen Jinwei , Liu Kezhi , Liang Hui , Wang Zhu , Deng Qiong , Wang Jieyan , Jin Meiyu , Chen Wei , Luo Junhang , Cao Jiazheng , Wei Jinhuan
Published: March 2024

Background Existing studies found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream genes. However, the specific functionalities and mechanisms of circRNAs in human clear cell renal cell carcinoma (ccRCC) have yet to be thoroughly investigated.Methods Patient cohorts from online database were used to screen candidate circRNAs, while another cohort from our hospital was obtained for validation. CircSOD2 was identified as a potential oncogenic target, and its relevant characteristics were investigated during ccRCC progression through various assays. A positive feedback loop containing downstream miRNA and target gene were identified using bioinformatics and was validated by luciferase reporter assays, RNA pull-down, and high-throughput sequencing.Results CircSOD2 expression was elevated in tumor samples and significantly correlated with overall survival (OS) and the tumor stage of ccRCC patients, which appeared in the enhanced proliferation, invasion, and migration of tumor cells. Through competitively bind to circSOD2, miR-532-3p can promote the expression of PAX5 and the progression of ccRCC, and such regulation can be salvaged by miR-532-3p inhibitor.Conclusion A novel positive feedback loop, PAX5/circSOD2/miR-532-3p/PAX5 was identified in the study, indicating that the loop may plan an important role in the diagnosis and prognostic prediction in ccRCC patients.