bluuebunny/crossref_metadata_2025 huggingface dataset:
UNDERSTANDING FREEDOM IN THE HIS ALL-HOLINESS ECUMENICAL PATRIARCH BARPHOLOMEW'S І ORTHODOX THEOLOGY
Authors:   Taras Shevchenko national University of Kyiv, Hnatovska Hanna
Published: May 2023

The article is devoted to the content of the understanding of freedom in the Ecumenical Patriarch Bartholomew's І theology. The path of personal comprehension and comprehension of freedom, which became one of the core foundations of the development of philosophical thought of the "Western world". It is difficult to find in the list of prominent thinkers of the history of Western philosophy from the beginning of our era someone who would not devote his efforts to understand freedom in accordance with a certain perspective of its problematization. The main directions of development of this topic in the history of philosophical and theological theories are outlined. The general context of Christian doctrine, which is the source of the problems of freedom in the "Western world" is revealed. The alternative angles of its understanding in Eastern philosophies where freedom appears, first of all, as a desirable goal, the achievement of which requires efforts, as opposed to the interpretation of freedom based on Abrahamic religions of God-given attributive property of human, which is a condition of both sin and salvation, are pointed out. The specificity of the modern interpretation of freedom in the conditions of secularism domination is determined, and the actuality of the Patriarch's position, which corresponds to the urgent challenges faced by humanity today, is clarified. The motive of "escape from freedom" in the cultures of the West is revealed, and the reasons for its emergence are clarified. Contrary to popular prejudice, according to which theology is always a factor of "conservation" and "dogmatization" of thought, Orthodox theology reflects modernity and illustrates both the depth of the historical duration of the Christian paradigm and the modern peaks of its development. Not only Ecumenical Patriarch Bartholomew І revealed the spiritual tradition of Orthodoxy, but also outlined possible ways to overcome the most pressing problems that require humanity to take responsibility for compliance with social justice and the protection of the natural environment. It is argued that the Ecumenical Patriarch Bartholomew's І position is an example of how religion from the source of conflict can become a guarantee of interfaith reconciliation and intercultural understanding. The development of Orthodox theology, as evidenced by Patriarch's works, is able to open new horizons of human unity around the meta-values of love and faith. Man's freedom is a manifestation of the fact that it was created in the image and likeness of God, it is possible thanks to the absolute and unconditional Freedom of the Creator, the comprehension of which exceeds man's ability to judge. True freedom of the individual is a guarantee of recognition of the "other's" freedom, and a necessary condition for a responsible position of an individual, capable of constructive and effective steps towards solving the urgent problems of mankind.
ACADEMIC CULTURE OF GENDER TOLERANCE IN THE EDUCATIONAL REALM
Authors:   Taras Shevchenko national University of Kyiv, Vlasenko Fedir , Levcheniuk Yevheniia ,   Taras Shevchenko national University of Kyiv, Atashkadeh Ruslana ,   Taras Shevchenko national University of Kyiv
Published: May 2023

The main objective is to develop an academic culture of gender tolerance as a basis for the protection of the rights and freedoms of gender minorities in the educational realm. In today's conditions (including pandemics, rapid development of information and communication technologies, etc.) there is a need to actualize the issue of tolerance in human communication. The article is focused on the problem of gender tolerance, finding ways to develop the rights and freedom of gender minorities in the educational realm. It is noted that the formation of gender consciousness is a necessary condition for the development of modern personality, a manifestation of which should be gender tolerance. Educational institutions play a leading role here as centers of academic culture, where, in particular, respect and tolerance for people of different sexual orientations and gender identities are nurtured. Different approaches in defining the concepts of "tolerance" and "gender tolerance" are considered. It is defined that the study of gender tolerance in the educational realm requires the use of both synchronous and diachronic methods, the deployment of an integrative research strategy – transdisciplinarity. Effective tools and mechanisms for protecting the rights and freedoms of gender minorities in the educational process are proposed.
ENVIRONMENTAL PHILOSOPHY OF ECUMENICAL PATRIARCH BARTHOLOMEW I
Authors:   Taras Shevchenko national University of Kyiv, Ilina Halyna
Published: May 2023

The article examines the ideas of environmentalism in the works and statements of His All Holiness Ecumenical Patriarch Bartholomew I. The ecological concept of the "Green Patriarch" reveals the relations between religion and the environment. The cause of the environmental crisis is recognized as a crisis of spirituality. It is argued in the concept that utilitarian logic and ethics are not enough to change human behavior towards the environment – ecological thinking requires another worldview that can be found in religion. In particular, from the point of view of Orthodox spirituality, the environment is a miracle of the Divine creation. Therefore, the world is a sacred place, a miracle, a place of beauty and communication with the Creator. Awareness of the beauty and harmony of the cosmos involves understanding the balance and measure. The way to achieve them is asceticism. The latter is realized through self-control, which is manifested in the balanced consumption and use of only the necessary resources and the abandonment of abusive consumption for the benefit of others. The universal principle of the philosophy and ethics of the environment is the instruction to preserve resources for future generations; this is repeatedly emphasized in the speeches and works of His Holiness Ecumenical Patriarch Bartholomew I.
PHILOSOPHICAL CONCEPTS IN THE ADDRESSES OF HIS ALL-HOLINESS, ARCHBISHOP OF CONSTANTINOPLE – NEW ROME AND ECUMENICAL PATRIARCH BARTHOLOMEW I
Authors:   Taras Shevchenko national University of Kyiv, Kononenko Taras
Published: May 2023

The subjects of the article are the philosophical concepts stated by His All-Holiness, Archbishop of Constantinople – New Rome and Ecumenical Patriarch Bartholomew I in addresses during his stay in Kyiv on the occasion of the 30th anniversary of Independence of Ukraine. These balanced canonical addresses in two languages, including Ukrainian, are independent subjects of philosophical analysis. All conceptual statements have a multidimensional character and can be studied in connection with the canonical, ecclesiastical, religious and philosophical grounds. The stay of His All-Holiness, Archbishop of Constantinople – New Rome and Ecumenical Patriarch Bartholomew I in Kyiv ended with the formation of an independent source base for historical and philosophical research. A set of philosophical terms and concepts that create an original philosophical lexicon was identified. Among the leading philosophical concepts, the polemical opposition of the "pyramidal structure of church organization" and the Eastern Orthodox Church "Pentarchy" model is distinguished by its energy. The historical and philosophical explication of the logical structure of both ways of building the Church is an important factor in elucidating the differences between the autocratic and equal in components systems. This philosophical concept and its careful study can be urgent in establishing strategic directions for the development of both the Orthodox Church of Ukraine and the secular system of government of the state of Ukraine, based on the principle of separation of powers into components. The addresses also contain a number of concepts of philosophical and theological content, which substantiate the logic of the "non-pyramidal" system of organization and have an unconditional modern meaning for the existing Ukrainian- language philosophical lexicon.
Experimental treatment of induced fetal retardation in model animals
Authors: Bespalova Olesya N. , Blazhenko Aleksandra A.
Published: May 2023

Intrauterine retardation is one of the major complications of pregnancy. This pathology occurs in approximately 10% of all pregnancies in developed countries and 20% in developing countries. Moreover, intrauterine retardation is more frequently associated with stillbirths than other pathologies. Despite studies conducted in the past 50 years, no generally accepted therapeutic regimen has yet been developed. Numerous drugs have been used for treatment; however, none of them has been proven effective. Moreover, after years of testing, new data are emerging about the side effects of the drugs previously used.
Various models of fetal retardation have been developed throughout the study of this problem. The main model animals are rats, pigs, and sheep. Numerous techniques and drug options have been proposed for the treatment of simulated intrauterine developmental delays in these animals. The main amino acids used for treatment were arginine, glutamine, taurine, and citrulline. Thus, the literature review aimed to analyze which model animals and experimental models of intrauterine retardation treatment most adequately reflect the effectiveness of these drugs.
Monoaminergic effects of the unilateral blockade of orexin receptors (OX1R) in the enlarged amygdala under psychostimulant action
Authors: Karpova Inessa V. , Bychkov Eugeny R. , Lebedev Andrei A. , Shabanov Petr D.
Published: May 2023

BACKGROUND: The search for new drugs potentially effective in stopping the development of pathological addictions is an urgent task of experimental psychopharmacology.
AIM: To examine the participation of brain monoaminergic systems in the mechanisms of the blocking effect of SB-408124 on the self-stimulation of the lateral hypothalamus activated with the psychostimulant -phenylisopropylamine (PIPA) treatment.
MATERIALS AND METHODS: Male Wistar rats pre-administered with psychostimulant (PIPA, 1 mg/kg intraperitoneally) were unilaterally injected with an orexin antagonist SB-408124 (1 g in 1 L) into the central nucleus of the amygdala or the bed nucleus of the stria terminalis (BNST). High-performance liquid chromatography with electrochemical detection was used to determine the levels of monoamines and their metabolites: norepinephrine (NA), dopamine (DA), serotonin (5-HT), dioxyphenylacetic (DOPAC), homovaniline (HVA), and 5-hydroxyindolacetic (5-HIAA) acids on the left and right sides of the prefrontal cortex, hippocampus, striatum, and olfactory tubercle.
RESULTS: Under the action of PIPA, microinjections of SB-408124 into the right central nucleus of the amygdala induced the following effects: prefrontal cortex, an increase in the levels of HVA and 5-HT on the right side and 5-HIAA on the left; hippocampus, bilateral increase in the levels of NA and HVA and 5-HT on the right; striatum, bilateral increase in the level of DA and the left-sided increase in HVA, 5-HT, and 5-HIAA. Microinjections into the left central nucleus of the amygdala caused a right-sided decrease in NA levels, an increase in 5-HT levels, and a left-sided decrease in DA and DOPAC levels in the striatum and a left-sided increase in HVA level in the olfactory tubercle. Microinjections into the right BNST caused a left-sided decrease in the levels of NA and DA in the prefrontal cortex, bilateral decrease in DOPAC levels, a right-sided increase in 5-HT levels, and a left-sided increase in 5-HIAA levels in the striatum; and a left-sided increase in HVA levels in the olfactory tubercle. Microinjections into the left BNST caused increased 5-HT levels in the left striatum and decreased DOPAC and 5-HIAA levels in the left olfactory tubercle.
CONCLUSIONS: Right-sided microinjections cause a greater number of changes in monoamine metabolism than left-sided ones. The introduction of SB-408124 into the right structures of the enlarged amygdala increases 5-HIAA levels in the left striatum, whereas microinjections in BNST lead to increased 5-HT levels in the ipsilateral striatum and in the contralateral in the central nucleus of the amygdala
A Study on the Differences in LDSP Business Models between Korea, United States, Japan, and China
Authors:   The Korean Logistics Research Association, Coo Byung-Mo
Published: May 2023

This paper is the results of studies of subjects that accord with the recent digital transformation, digital twin, sharing economy, logistics O2O, logistics digital platform, etc., and can be jointly used and can collaborate with AI, Big Data, AMR, AGV, UAM, etc. The core studied field is the logistics digital sharing platform(LDSP) business model, which is called an online-based logistics sharing economy business model. Based on South Korean LDSP, the models in the same field were studied with companies representing the United States, Japan, and China. Due to the influence of the COVID-19 pandemic, instead of studies abroad, studies were conducted with online, bibliographic studies, studies in which experts in the relevant country participated, and the heads of South Korean corporations installed in the relevant countries through general and in-depth interviews. Using the business model canvas(BMC) as a research methodology, nine components of the BMC were used as a means of comparison of LDSP business models by country as key factors. As a result of the study, differences were derived from components VP, CRM, RS, KA, and KP in the LDSPs in South Korea and the United States, and differences in components VP, CRM, RS, and KR were studied in the Japanese LDSP. In comparison with LDSP in China, differences were derived from components VP, CRM, and KA.
A Study on the Effects of Coupang Platform’s Logistics Service Quality on Satisfaction, Trust and Repurchase Intention
Authors:   The Korean Logistics Research Association, Wang Jinzhi , Zhang Mengze
Published: May 2023

In modern society, with the increasing number of online shopping platforms and their development, various platforms have also launched logistics services such as same-day delivery and morning delivery, and the competition among platforms has become more intense. Therefore, it is necessary to study the influence of logistics service quality, user satisfaction and trust on user repurchase intention. In addition, the flexibility of platform logistics services is an important boost to help the platform succeed and meet the needs of different groups, but there is currently a lack of relevant demonstration research. Therefore, based on the theoretical background of logistics service quality in online shopping, this study combines order quality, delivery quality, information quality, customer service and the flexibility of the Coupang shopping platform to construct a research model and establish hypotheses. From January 6 to February 3, 2023, a questionnaire survey was conducted in the form of a Google questionnaire for Coupang users with experience in using and purchasing. At the end of the investigation, a total of 500 questionnaires were received, except for 47 questionnaires with no purchase history and 49 dishonest ones, the remaining 404 questionnaires were statistically analyzed using SPSS, and finally analyzed. The results of this study show that, first of all, in terms of logistics service quality, order quality, delivery quality, customer service, and flexibility have certain positive (+) effects on satisfaction. However, information quality did not affect satisfaction. This means that the quality of information related to orders, transactions, and logistics on the platform cannot meet consumers’ expectations. Second, the quality of logistics services has a positive (+) impact on information products. Third, satisfaction and trust have a positive (+) impact on all users’ repurchase intentions. Many people are likely to become loyal users of the platform. This study reveals a causal relationship between flexibility and satisfaction and trust, with important implications. And it proves that consumers’ repurchase intention is based on excellent product and logistics service quality
Prevalence of hepatitis C virus infection among hemodialysis patients: cohort study
Authors: Aruna Dimie , Adereti Abubakar , Munir Easley A.
Published: May 2023

Hepatitis C virus (HCV) is a blood-borne virus that primarily infects the liver and can cause both acute and chronic hepatitis. HCV is one of the leading causes of liver disease worldwide and can lead to cirrhosis, liver failure, and liver cancer if left untreated. Dialysis is the most common reliable and accessible therapeutic approach in end-stage renal disease (ESRD) which increases survival and life expectancy in patients. Despite the screening tests on blood products and devices, nosocomial infections are one of leading causes of morbidity and mortality in ESRD. HCV is more prevalent in ESRD compared to the general population, with an overall prevalence of 9.9% among chronic hemodialysis (CHD) patients in high- and middle-income countries. The objective of this study is to assess the prevalence of occult HCV infection in CHD. All clinical, and demographic data was registered beside blood samples, serological testes and HCV-RNAs from 95 patients; 60.7% were male, with mean age of OCI positive cases was 32.3 ± 14.3 years. Furthermore, three case had detectable viral load which was 54 IU/ml. Inconclusion, there is a risk of OCI among CHD patients that needs follow-up by molecular testing.
A Study on the Innovation Procurement System: Focusing on the diversification of procurement ways
Authors:   The Legal Studies Institute of Chosun University, Lee Jehee
Published: May 2023

Public procurement is the purchase of necessary goods, services, and construction by public institutions. Since public procurement uses taxes as a resource, efficiency should be prioritized in public procurement. However, considering that the purpose of public procurement is to promote the public interest, public entities can intervene in the market beyond the status of buyers.
In the era of the 4th Industrial Revolution, it is important to preoccupy the early market. It is difficult to induce corporate innovation only with traditional policies, such as preferential treatment of SMEs in the public sector. Creating new demand in the market, such as the purchase of prototypes by the public sector, can lead to corporate innovation, which is the starting point for innovation procurement. Innovation procurement can induce private innovation, and the problems faced by the public sector can be solved using private innovative ideas.
The current innovation procurement system of Korea focuses on ‘Pre-Commercial Procurement’(PCP)'. It is necessary to support from the R&D stage of the product and create a new market by linking it with public procurement. Therefore, the 'Public Procurement of Innovation’(PCI) should be introduced in innovation procurement.
Problems and Improvement Plans of the Child Support Agency
Authors:   The Legal Studies Institute of Chosun University, Jun Gyung Gun
Published: May 2023

Discussions on strengthening the performance of child support began in 2004. This is because the number of single parents who raised minors increased according to the rapid increase of divorce rate at that time. Initially, the Civil Act was amended to make an agreement on child support expenses as an essential procedure in a divorce by agreement, so that an agreement on the burden of child support was reached between divorced couples. However, given that it was not enough to prepare for compulsion of performance, the court can draw up a report on the burden of child support so that it could be enforced immediately. However, considering that it is difficult for single parents to carry out compulsory execution proceedings on their own, an institution was established that could force the implementation of child support. This is a legislative result about the institution of child support performance that was finally made after a decade of discussion in the Ministry of Gender Equality and Family since 2005. However, by placing the Child Support Agency under the Korean Institute for Healthy Family, it has not been able to secure its status as an independent institution. Therefore, as it became difficult for the Child Support Agency to conduct its own duties and proceed with the lawsuit, it caused a problem of delaying the compulsory performance of chil support. In foreign countries, all child support performance institutions are state agencies or administrative agencies, independent institutions, and have the authority to identify the address or property of the child support debtor. However, our Child Support Agency only secures its status as a public institution. In addition, since the work of the Korean Institute for Healthy Family and Child Support Agency are different, it is difficult to organically combine them to perform the work of compulsory child support. Furthermore, in order to accomplish a result regarding instead payment of child support, which is under discussion recently, the Child Support Agency must have appropriate authority to handle the work. The independence and authority of the Child Support Agency should be strengthened as soon as possible.
Fungal polysaccharides and their hypoglycemic potential to act as an adjuvant in the treatment of diabetes mellitus
Authors: Figueroa Gabriel Macêdo , Costa Danilo Nascimento , Miranda Alana Caise dos Anjos , Valasques Júnior Gildomar Lima , Mendes Tátilla Putumujú Santana , Cedro Pâmala Évelin Pires
Published: May 2023

Diabetes mellitus is considered a serious public health problem because it affects millions of individuals and causes numerous complications. The constant adverse effects of conventional therapies for diabetes mellitus have stimulated research that seeks new forms of treatment, prevention and control. Polysaccharides obtained from fungi are promising as adjuvants for the control of diabetes mellitus. This study is a literature review that sought to evaluate the hypoglycemic properties of polysaccharides obtained from fungi and understand the main mechanisms of action involved. The main mechanisms reported in the studies resulting in a decrease in glycemia were the inhibition of digestive enzymes such as α-amylase and α-glucosidase, action on the IRS1, PI3K, JNK1 signaling pathways, antioxidant, anti-inflammatory, hypolipidemic capacity and stimulation of the intestinal microbiota.
Educação para o trabalho e ditadura militar: Prescrições da Lei n.º 5.692/1971 e suas interpretações para o ensino de ciências a partir de uma revista (Paraná, 1973)
Authors: Zaluski Jorge
Published: May 2023

A Lei de Diretrizes e Bases da Educação n.º 5.692, de 11 de agosto de 1971 (Lei n.º 5.692/1971), ao instituir o ensino profissional como compulsório para a formação de segundo grau, e a obrigatoriedade em qualificar para o trabalho, desde o Ensino Fundamental, contribuiu para que fosse reestruturado todo o sistema educacional brasileiro. No conjunto de ações, no estado do Paraná, a publicação da revista Currículo, a partir de 1973, expressa forte atenção em atender as prescrições da legislação. Tomando a edição de número 3, de 1973, como documentação histórica, busca-se investigar sobre parte das prescrições curriculares para o estado do Paraná, a partir da óptica da revista. Com ênfase nas recomendações para atender o conjunto de disciplinas voltadas à área de ciências — Matemática; Ciências Físicas; Ciências Biológicas e Programas de Saúde — apresentadas pelo documento, pretende-se analisar as prescrições endereçadas a essas disciplinas. Acredita-se que, a partir desta análise, seja possível identificar parte da trajetória dessas disciplinas na história da educação, compreender os objetivos e interesses dos enunciados a partir da educação para o trabalho e das particularidades do conjunto curricular.
Education for work and military dictatorship: Provisions of Law no. 5.692/1971 and its interpretations for science teaching based on a magazine (Paraná, 1973)
Abstract
The Law of Guidelines and Bases of Education No. 5,692, of August 11, 1971 (Law No. 5,692/1971), by establishing professional education as compulsory for secondary education, and the obligation to qualify for work, starting from elementary school, contributed to its restructuring the entire Brazilian educational system. In the set of actions, in the state of Paraná, the publication of the magazine Currículo, from 1973 onwards, expresses strong attention to complying with the prescriptions of the legislation. Taking edition number 3, from 1973, as historical documentation, we seek to investigate part of the curricular prescriptions for the state of Paraná, from the perspective of themagazine. With an emphasis on recommendations to meet the set of subjects related to the area of science—Mathematics; Physical Sciences; Biological Sciences and Health Programs—presented by the document, it is intended to analyze the prescriptions addressed to these disciplines. It is believed that, based on this analysis, it is possible to identify part of the trajectory of these disciplines in the history of education, to understand the objectives and interests of the statements based on education for work and the particularities of the curricular set.
Enhancing Profitability and Yield Potential of Weed Controlling in Green Gram (Vigna radiata L.) under Central Plains of Punjab
Authors: Vyvahare L.S. , Menon S. , Khose P.J. , Sale M.S Na-Allah , Dhamapurkar V.
Published: May 2023

Background: The first 30 DAS are crucial for the green gram crop while competing with crop weeds. Weed competition with light, water, nutrients and space has an impact on the development and growth of crops. Green gram yield loss is reduced by weed by about 50–80%. The switch of unwanted plant throughout the early stages of crop development is crucial. Methods: The methodology was lead in the two successive years of Kharif, 2021 and 2022 eight weed-controlling treatments were used in an RBD. The weed count of each plot remained measured in field using two quadrates measuring 25 cm x 25 cm. The weight of seeds, straw and dry biomass of weeds were measured by weighing balance. The collected samples of green gram were determined by yield attributes, yield and net monetary returns. Result: The consequences of finding are minimum weed population (6.01 m-2) and weed dry biomass (0.37 g m-2), maximum weed control effectiveness (87.51%), achieve yield characteristics for instance number of pods per plant (21.26), number of grains per pod (11.99), test weight (32.86 g), straw yields (24.48 q ha-1) were noted with Pendimethalin (1000 g ha-1) 2 DAS (PE) combined with Imazethapyr (50 g ha-1) 30 DAS (PoE). It can be used for extremely active weed control to upper seed yield (7.25 q ha-1) and maximum net profits (₹ 36738 ha-1) besides higher benefit cost ratio (1:96 respectively) of green gram.
Evaluation of Red Cell Distribution Width (RDW) in Anemic Goats
Authors: Saravanan M. , Ranjithkumar M. , Ramkumar P.K. , Kannan K. , Kumar S. Senthil
Published: May 2023

Background: Red cell distribution width (RDW) measures the degree of anisocytosis in an erythrocyte population and was expressed as the coefficient of variation of the erythrocyte size distribution data. In recent studies, RDW has been evolved as a new predictive marker and as an independent risk factor in assessing the severity and progression of disease conditions. The data regarding RDW in goats was found lacking particularly in conditions like anemia. Methods: The study was conducted at Veterinary Clinical Complex, VCRI Orathanadu. The EDTA blood samples from suspected cases were collected and analyzed by Veterinary specific automated hematology analyzer. During the study goats with hemoglobin values lesser than and or equal to 8.0 g/dl were selected to evaluate the RDW alterations in them. Result: The Red cell distribution width was found elevated (36.94±0.29%) in anemic goats when compared to the healthy reference. The data of the Red cell distribution width in goats was recorded and statistically analysed.
Fracture Management of the Fifth Phalanx of the Cranial Dexter Extremity in Golden Retriever
Authors: Triyatmoko Anang , Rickyawan Nofan , Rifah Anggun
Published: May 2023

Fractures in animals are traumatic events that often occur. However, now the incidence of fractures can be well managed with the development of fixation techniques and various combination of anasthesia, as well as supporting equipment. This case study aims to determine the treatment of digiti fracture case, obtained from the Gaia Animal Clinic Surabaya. A ten-year-old Golden Retriever has a fractured the 5th digit of his righ cranial extremity. Radiographs, complete blood counts, blood chemistry, and electrocardiograms were taken to help confirm the diagnosis. The orthopedic surgery performed was internal fixation method using lag screw technique. Bone healing was evaluated by taken radiography and no complications were found. Wound healing was assisted by rehabilitation therapy using lasers. The 4th postoperative day, patient was discharged. Patient was able to walk even though he was still limping, the stitches were neatly closed, there was no seroma, around the stitches were swollen and redness.
The Labor of Medical Workers in the USA: A Social Aspect
Authors: Sautkina V.
Published: May 2023

The shortage of medical personnel is becoming a heavy burden on modern healthcare systems around the world. All countries, without exception, turned out to be vulnerable, regardless of the level of income and available forms of medical care. This study addresses the issue of staffing at the time of transition to a new technological level of the healthcare system in the United States. The paper shows that at the present stage in the country there is a need for fundamental changes in the personnel policy in the medical field. The challenges caused by the COVID‑19 pandemic not only exposed all the vulnerabilities of the national health system, but also opened up opportunities considering the lessons learned to rethink the long-term vision of solving the workforce problems directly related to the use of new technologies. Based on the analysis of statistical data and sociological research, the author identified the latest trends of overcoming barriers in the field of training and retraining of personnel in the context of the transition to digital medicine. Overexertion among medical personnel associated with increased workload has exacerbated the problem of their professional burnout. The mass protests of physicians necessitated the development of new approaches to the labor protection of employees in the medical field. Solution of such important social problems will require a long time and financial costs and is possible only through the joint efforts of the state and the entire community as a whole.
Efektivitas Edukasi Permainan Ular Tangga terhadap Peningkatan Pengetahuan dan Tindakan Memakai Masker dan Mencuci Tangan pada Anak selama Pandemi Covid-19
Authors: Afghani Apriliana , Ennimay  , Wisanti Eka
Published: May 2023

Education to prevent the spread of Corona Virus Deases 19 in children is urgently needed. Efforts to increase children's knowledge and action in preventing COVID-19 can use media that are interesting and fun like snake and leadder game.

 This study aimed to determine the effectiveness of education using snake and ladder media on the knowledge and action of wearing masks and washing hands in children during the COVID-19 pandemic.

 The research design was pre-experimental with the type of One-group pretest-posttest design. Total 38 children recruited by simple random sampling technique partisipated. The research instrument used a questionnaire sheet. Data analysis included univariate and bivariate analysis with paired t test

 Results showed that there were differences in the average knowledge and action of respondents before the study was carried out, which increased after education using snakes and ladders media was p value 0.001.

 It concluded that education using media snake ladder game improved respondent knowledge and behavior. The study finding suggested that every person who want to educate children can use the snake and ladder game as a medium to iinprove their knowledge and behavior.
The Effect of Inhaler Training on Self-Efficacy among Patients with COPD
Authors: Choiruna Hasby Pri , Sitorus Ratna , Kariasa I Made
Published: May 2023

Patients with Chronic Obstructive Pulmonary Disease (COPD) can have low self-efficacy due to symptoms of shortness of breath and cough. Proper use of an inhaler is able to overcome these symptoms. The majority of COPD patients are still using inhalers incorrectly. Inhaler use training can improve the technique of inhaler use and is expected to improve self-efficacy in COPD patients. The purpose of this study was to determine the effect of inhaler training on self-efficacy in COPD patients. The research design used a quasi-experiment with a nonequivalent control group pretest-postest. Thirty-six patients with COPD were selected using consecutive sampling and were divided into groups that followed the inhaler training and those who did not follow the inhaler training. The results showed that there was a significant improvement in self-efficacy in COPD patients by 9.33 score after the inhaler training (p=0.001; p<0.05) and there was a significant difference in self-efficacy change of 6 scores compared to COPD patients who did not follow the inhaler training (p=0.000; p<0.05). In conclusion, there was an influence of inhaler training on self-efficacy in COPD patients so inhaler training is recommended to that nurses to be given to COPD patients.
Stres Akademik dan Mekanisme Koping Mahasiswa pada Masa Pandemi Covid-19
Authors: Irfada Sita Irnadianis , Keksi Girindra Swasti  , Reza Fajar Amalia
Published: May 2023

Background: The Covid-19 pandemic has an impact on learning patterns so that it requires students to adapt to this situation. The stressor is felt more by first year students because they have to make adjustments to a different academic environment while in high school. Objective: The aim of the research is to describe the academic stress and coping mechanisms of health fakulty students. Method:This study uses a quantitative descriptive research design. The research population was health fakulty Unsoed students. Samples were selected using Stratified Random Sampling techniqueand obtained respondents a number of 269 respondents. This research uses academic stress inventory questionnaire and stress coping style inventory. Data analysis was performed univariately. Result: Characteristics of the majority of respondents were women (77.3%), aged 18 years and came from the nursing department (24.5%). The highest frequency of academic stress experienced by students is teachers stress (188), results stress (210), tests stress (218), studying in group stress (167), peer stress (126), time management stress (126), self - inflicte stress (154). As for the application of coping mechanisms, the majority of respondents applied active emotional coping, 177 respondents (65.8%). The highest score on the academic stress questionnaire is found in the 15th item, namely 125 (46.5%) respondents. Conclusion: The majority of students apply active emotional coping in dealing with academic stress. It is better if the application of coping mechanisms to students is not only aimed at calming down, but also being able to solve existing problems
PENGARUH EKSTRAK DAUN COCOR BEBEK (Bryophyllum pinnatum) TERHADAP PERTUMBUHAN Escherichia coli WILD-TYPE DAN ATCC 35218
Authors: Krisniawati Nia , Fadiah Nurul , Putranti Ismiralda Oke
Published: May 2023

Indonesia merupakan negara yang memiliki banyak keanekaragaman hayati dan hewani yang bermanfaat sebagai obat tradisonal yang dapat menjadi pengobatan alternatif. Salah satu tumbuhan yang dapat digunakan adalah bagian daun dari tumbuhan Cocor Bebek yang memiliki manfaat seperti antibakteri, anti diabetes, anti oksidan, dan sebagainya serta mengandung senyawa aktif seperti flavonoid, alkaloid, saponin dan steroid. Escherichia coli adalah flora normal yang bersifat patogen dalam tubuh. Pemberian ekstrak daun Cocor Bebek yang bersifat antibakteri diperkirakan memiliki efek yang dapat menghambat pertumbuhan bakteri Escherichia coli wild-type dan ATCC 35218. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak daun Cocor Bebek dalam menghambat pertumbuhan bakteri Escherichia coli wild-type dan ATCC 35218. Penelitian ini merupakan penelitian eksperimental nyata dengan rancangan Post-Test-Only Control Group Design. Daun Cocor Bebek diekstraksi dengan metanol menggunakan metode maserasi. Sampel penelitian terdiri dari biakan murni Escherichia coli wild-type dan ATCC 35218 dengan kepadatan 1,5 X 108 sel/ ml. Pengujian dengan metode Difusi Cakram Kirby Bauer dengan konsentrasi ekstrak 20%, 40%, 60%, 80%, aquades sebagai kontrol negatif dan amoxicillin-clavulanat sebagai kontrol positif. Hasil penelitian menunjukkan ekstrak daun Cocor Bebek tidak dapat menghambat pertumbuhan bakteri Escherichia coli ATCC 35218 dan Escherichia coli wild-type karena kemungkinan kedua bakteri termasuk dalam bakteri ESBL. Pada penelitian sebelumnya mengatakan bahwa 66,7% komunitas yang ada di Purwokerto merupakan carrier tanpa gejala. Kesimpulan penelitian ini, ekstrak daun Cocor Bebek tidak memiliki efek penghambatan dalam pertumbuhan bakteri Escherichia coli wild-type dan ATCC 35218.
PREDIKSI PERAN CURCUMINOID PADA CURCUMA LONGA SEBAGAI INHIBITOR GSK-3 TERHADAP PERTUMBUHAN DENTIN TERSIER
Authors: Fithriyya Naila Robbaniyya , Syafa Hanifah Nur , Financia Dwi Cinthya , Cahyaningrum Nadya Elsa , Wijayanti Husni Rama , Nabila Haidy Lailatun , Kayana Salma Kaltsum , Putri Ghaida Humaira Susilo , Tanjung Nurul Hasanah , Widyaningsih Pratiwi Nur , Purnama Ryana Budi , Wardhana Tirta
Published: May 2023

Caries is one of the most common oral diseases. Tertiary dentin regeneration has recently been developed as an alternative treatment for caries. Curcuminoids are known to have the ability to inhibit GSK-3β in the Wnt signalling pathway to accelerate the formation of reparative dentin. This study aimed to investigate curcuminoids as GSK-3β inhibitors in modulating tertiary dentin formation through the Wnt pathway. Insilico analysis has been carried out using an online database and software. Data collection is done through the Protein Data Bank https://www.rcsb.org/ dan PubChem https://pubchem.ncbi.nlm.here.gov/. The analysis of interactions between proteins and bioactive compounds through the STITCH website http://stitch.embl.de/ dan STRING https://string-db.org/.The results obtained that STK3 protein that binds to curcuminoids has a hippo signalling pathway that inhibits GSK-3β in the Wnt pathway. The study concludes that curcuminoids have the potential to accelerate the development of tertiary dentin.
Authors: Yasyfi Nurul Salma , Dwi Lestari Diyah Woro , Nurlaela Nurlaela , Paramitha Hilma
Published: May 2023

Adolescence is a transitional period from early childhood to adulthood which has an important role in the future. In carrying out their developmental tasks, adolescents will experience various kinds of problems. The amount of pressure experienced by adolescents could make adolescents have high levels of stress and allow adolescents to have suicidal thoughts. The purpose of this study was to determine the correlation between stress levels and the emergence of suicide ideation among SMA X students in Banyumas Regency. This study used an observational analytic research method with a cross sectional research design. Total sampling was used as the sampling technique with 205 students as samples. The level of stress and the emergence of suicide ideation were measured using a questionnaire. The Spearman test was used to find the correlation between variables. Based on the research results, it was found that the respondents' stress level was generally categorized as normal. There was no the emergence of suicide ideation among SMA X students in Banyumas Regency. The results of statistical tests using the Spearman test obtained significant results. The results of this study indicate that there was a correlation between the level of stress and the emergence of suicide ideation and the direction of the positive relationship. There was a positive correlation between the level of stress and the emergence of suicide ideation in SMA X students in Banyumas Regency. Adolescent are advised to be more able to be critical, especially when facing problems.

Keywords: secondary school student, stress level, the emergence of suicide ideation
VALIDITY AND RELIABILITY TEST OF NORDIC MUSCULOSCELETAL QUESTIONNAIRE (NMQ) FOR BLUE-COLLAR WORKER
Authors: Burkon Lily Kusumasita
Published: May 2023

Gangguan muskuloskeletal mempengaruhi produktivitas kerja pekerja industri manufaktur, khususnya garmen. Nordic Musculoskeletal Questionnare (NMQ) dapat berfungsi sebagai instrumen identifikasi atau penilaian risiko yang harus penuh dengan persyaratan validitas dan reliabilitas. Validitas dan reliabilitas pekerja kerah biru versi Nordik Muskuloskeletal Questionnare (NMQ) versi Indonesia merupakan kelanjutan dari validitas sebelumnya di Indonesia. Penelitian ini bertujuan untuk mendapatkan validitas dan reliabilitas Nordic Musculosceletal Questionnare (NMQ) dalam Bahasa Indonesia yang dapat digunakan untuk pekerja kerah biru. Kuesioner terjemahan menyederhanakan kata-kata dalam kalimat dan bahasa melalui panel diskusi ahli. Kuesioner telah diuji untuk mengetahui uji korelasi dan validitas antar butir, kemudian diuji reliabilitasnya dengan teknik pengukuran yaitu dalam waktu 7 hari untuk mendapatkan nilai Alpha Chronbach. Penelitian ini dianalisis dengan menggunakan SPSS 20 untuk hasil akhir. Penelitian menunjukkan bahwa responden yang memiliki latar belakang pendidikan maksimal SMA memberikan nilai validitas angket adalah mayoritas skor kuat (0,600 – 0,777) dan hasil angket uji reliabilitas pada penelitian pertama dan kedua memiliki nilai Alpha Cronbach yang hampir sama tingginya (0,965 – 0,966) dan berarti sangat reliabel.
THE RELATIONSHIP BETWEEN PERCEPTIONS OF SOCIAL SUPPORT WITH STRESS LEVELS OF HOSPITAL INPATIENT PATIENTS
Authors: Zamri Rafika , Wahyudin Wahyudin , Hidayah Arfi Nurul , Dwi Lestari Diyah Woro , Nur Hestiyani Rani Afifah
Published: May 2023

Background: Hospitalization requires the patient to undergo treatment at the hospital. This can be a stressor for some patients. Interaction with health professionals and family can help patients cope with stress. Furthermore, social support from friends might help enhance one's health. The purpose of this study is to evaluate the association between inpatients' perceptions of social support and stress levels.

Method: This study employed a cross-sectional analytic descriptive observational method. Purposive sampling was used to choose 30 inpatients from the internal care room at Margono Soekarjo Hospital in Purwokerto for this investigation.

Results: In this study, 86.7% of patients had normal stress levels. Support in the high category was primarily provided by family. In the correlation test, the significance value between the stress level of hospitalized patients and the sense of family support is 0,703, friends are 0,815, and significant others are 0,249 (p<0,005). It means that there is no significant correlation between variables.

Conclusion: There is no correlation between inpatients' perceptions of family support, friends, and significant others and their stress level.
DESCRIPTION OF THE KNOWLEDGE AND ATITUDES OF POSTPARTUM OTHERS ABOUT BREAST CARE BEFORE AND AFTER GIVING THE MODULE IN THE WORK AREA OF THE MANGNGARABOMBANG HEALTH CENTER 2022
Authors: Kartini Anita , Nuryana Riska Nuryana Riska , Ernawati Ernawati , Zainuddin Zainuddin
Published: May 2023

Background:Breast care is very important during pregnancy and breastfeeding. Because the breast is the only producer of breast milk which is the staple food for newborns, this should be done as early as possible during pregnancy. Research focus:Formation of knowledge and attitudes of pregnant women about breastfeeding before and after implementing the module in the working area of the Manggarabombang Health Center in 2022. Research method:This type of research is descriptive. This research included all mothers who gave birth in the working area of the Manggaratombang Health Center in 2022. The sample for this study was postpartum mothers in the villages of Banggae and Topezawa, totaling 34 people. Research result: A total of 34 respondents. The previous data showed 30 people with low qualifications (88.2%), 4 people with sufficient qualifications (11.8%) and 0 people (0%) were in the "good" category. ). According to the information provided, at least 30 people indicated less knowledge (88.2%), at least 4 people in the sufficient knowledge category (11.8%) and 0 people in the good knowledge category (0%).

Keywords:Knowledge, attitude, mother after giving birth, breast care
CHARACTERISTICS OF CERVICAL CANCER PATIENTS UNDER 40 YEARS OLD AT REGIONAL GENERAL HOSPITAL PROF DR MARGONO SOEKARJO PURWOKERTO PERIOD JANUARY 1–DECEMBER 31 2022
Authors: Aditiyono Aditiyono , Sutrisno Sutrisno , Priyanto Edi
Published: May 2023

Background: Cervical cancer is one of the most common cancers as a cause of death in women worldwide, accounting for around 500,000 new cases detected and 250,000 deaths each year. Around 80% of cases occur in developing countries. This objective study is identifying the profile and distribution of 40 years old women with cervical cancer in Prof dr Margono Soekarjo Purwokerto Hospital on January 2022-December 2022.

Method: A retrospective descriptive design was conducted by using samples from all the medical record of under 40 years old female patients with cervical cancer in Prof dr Margono Soekarjo Purwokerto hospital on January 2022-December 2022. Samples were selected by purposive sampling that met the inclusion criteria, and the data was presented in table form.

Results: There were 58 patients with cervical cancer in women aged under 40 years where the majority of the age group 30 - 39 years were 50 people (86.2%). While the highest parity was in the 2-3 parity group of 33 people (56.8%). For the most dominant stage of cervical cancer female patients under the age of 40 years is stage IIIB with a total of 26 people (44.8%). NKSCC was the most common histopathological appearance in this study, namely 33 people (60.3%).

Conclusion: The dominant risk factor obtained in cervical cancer patients under the age of 40 years at Prof dr Margono Soekarjo Purwokerto hospital is multiparity. The average cervical cancer patient under the age of 40 comes in the advanced stage with the most histopathological features is Squamous Cell Carcinoma type Non Keratinizing