bluuebunny/crossref_metadata_2025 huggingface dataset:
Probability Paradoxes for Increasing Critical Thinking Skills
Authors: Wijayatunga Priyantha
Published: October 2024

Critical thinking skills are important assets for scientific development. Therefore, there are many ways to enhance the critical thinking skills of students, researchers, etc., both in the field of education and scientific enterprise. In this article, we propose the practice of solving probability paradoxes and puzzles for the purpose since these problems are often complex, subtle and tricky; therefore, their solutions require many aspects of critical thinking. In the following, the Introduction outlines some of the current research on the topic without going into more details. We provide background descriptions of the paradoxes and probability paradoxes in Section 2. Section 3 provides a short description of critical thinking. We present several definitions since there is no clear consensus on one single definition, both in the literature and in the general literature. And in Section 4 current research on using puzzles for enhancing critical thinking is given. We then discuss several probability paradoxes, namely, the Monte Hall paradox, the two-envelope (exchange) paradox and the St. Petersberg paradox, in Sections 5, 6 and 7, respectively. In Section 8, a brief discussion of the statistical hypothesis testing is given emphasizing its controversial nature. We analyse these problems and concepts in such a way that critical thinking is evoked while keeping the technical details to a minimum.
An Intelligent Approach to Automated OS Log Analysis for Enhanced Security
Authors: Johnphill Obinna , Safaa Sadiq Ali , Kaiwartya Omprakash , Aljaidi Mohammad
Published: October 2024

Self-healing systems have become essential in modern computing for ensuring continuous and secure operations while minimising downtime and maintenance costs. These systems autonomously detect, diagnose, and correct anomalies, with effective self-healing relying on accurate interpretation of system logs generated by operating systems (OS). Manual analysis of these logs in complex environments is often cumbersome, time-consuming, and error-prone, highlighting the need for automated, reliable log analysis methods. Our research introduces an intelligent methodology for creating self-healing systems for multiple OS, focusing on log classification using CountVectorizer and the Multinomial Naive Bayes algorithm. This approach involves preprocessing OS logs to ensure quality, converting them into a numerical format with CountVectorizer, and then classifying them using the Naive Bayes algorithm. The system classifies multiple OS logs into distinct categories, identifying errors and warnings. We tested our model on logs from four major OS; Mac, Android, Linux, and Windows; sourced from Zenodo to simulate real-world scenarios. The model's accuracy, precision, and reliability were evaluated, demonstrating its potential for deployment in practical self-healing systems.
Hepatitis A Seroprevalence Among HIV-Exposed and Unexposed Paediatric Populations in South Africa
Authors: Amponsah-Dacosta Edina , Ratshisusu Lufuno , Modise Lorato M , Blose Ntombifuthi , Simani Omphile E , Selabe Selokela G , Kagina Benjamin M , Muloiwa Rudzani
Published: October 2024

Limited evidence on hepatitis A seroprevalence among HIV-exposed uninfected (HEU) children compared to their HIV infected (HIV) and unexposed uninfected (HUU) counterparts compromises rational vaccine decision-making. This study comprised of a retrospective health facility-based population of children aged 1 month – 12 years. Archival sera were tested for markers of acute (anti-HAV IgM) or past (total anti-HAV) HAV infection. Subgroup analysis was conducted based on HIV exposure or infection status. Of 513 participants, 54% (277) were male and the median age was 10 (IQR: 4 – 25) months. The median maternal age was 29 (IQR: 25 – 34) years. An anti-HAV seropositivity of 95.1% (117/122 [95% CI 90.2-98.4]) was found among those ≤6 months of age, indicative of the rate of transplacental antibody transfer. Among 1–12-year-olds, hepatitis A seroprevalence was 19.3% (37/192 [95% CI 14.1-25.7]), while 1.1% (2/188 [95% CI 0.12-2.76]) had evidence of acute infection. Compared to HIV-exposed subgroups (HIV=60%, 6/10 [95% CI 27.4-86.3] and HEU=45%, 9/20 [95% CI 23.8-68]), hepatitis A seroprevalence among HUU children was low (29.2%, 47/161 [95% CI 22.4-37.0]). Natural immunity among HIV -exposed and -unexposed children in South Africa is insufficient to protect against severe liver complications associated with HAV infection later in adulthood.
Recent Advances in Hybrid Nanocomposites for Aerospace Applications
Authors: Monteiro Beatriz , Simões Sónia
Published: October 2024

Hybrid nanocomposites have emerged as a groundbreaking class of materials in the aerospace industry, offering exceptional mechanical, thermal, and functional properties. These materials, composed of a combination of metallic matrices reinforced with a mixture of nanoscale particles, such as carbon nanotubes (CNTs), graphene, and ceramic nanoparticles (SiC, Al2O3), provide a unique balance of high strength, low weight, and enhanced durability. Recent advances in developing these nanocomposites have focused on optimizing the dispersion and integration of nanoparticles within the matrix to achieve superior material performance. Innovative fabrication techniques have ensured uniform distribution and strong bonding between the matrix and the reinforcements, including advanced powder metallurgy, stir casting, in-situ chemical vapor deposition (CVD), and additive manufacturing. These methods have enabled the production of hybrid nanocomposites with improved mechanical properties, such as increased tensile strength, fracture toughness, wear resistance, and enhanced thermal stability and electrical conductivity. Despite these advancements, challenges remain in preventing nanoparticle agglomeration and ensuring consistent quality and repeatability in large-scale production. Addressing these issues is critical for fully leveraging the potential of hybrid nanocomposites in aerospace applications, where materials are subjected to extreme conditions and rigorous performance standards. Ongoing research is focused on developing novel processing techniques and understanding the underlying mechanisms that govern the behavior of these materials under various operational conditions. This review highlights the recent progress in the design, fabrication, and application of hybrid nanocomposites for aerospace applications. It underscores their potential to revolutionize the industry by providing materials that meet the demanding requirements for lightweight, high-strength, and multifunctional components.
Phenotypical Differences Between the Epidemic Strains of Vesicular Stomatitis Virus Serotype Indiana 98COE and IN0919WYB2 Using an In-Vivo Pig (Sus scrofa) Model
Authors: Hole Kate , Sroga Patrycja , Nebroski Michelle , Handel Katherine , Lung Oliver , Spinard Edward , Zarate Selene , Nfon Charles , Rodriguez Luis L , Babiuk Shawn , Mire Chad , Velazquez-Salinas Lauro
Published: October 2024

During the past 25 years, vesicular stomatitis virus (VSV) has produced multiple epidemic outbreaks in the US, resulting in the emergence of different viral lineages. Currently, very little is known about the pathogenesis of many of these lineages, thus limiting our understanding of the potential biological factors favoring each lineage in these outbreaks. To determine the potential phenotypical differences between two VSV Indiana (VSIV) serotype epidemic strains using a pig model. These strains are representative of the epidemic lineages that affected the US between 1997-1998 (IN98COE) and 2019-2020 (IN0919WYB2), the latter responsible for one of the most extensive outbreaks in the US. Our initial genome analysis revealed the existence of 121 distinct mutations between both strains, including the presence of a 14-nucleotide insertion in the intergenic region between G and L genes observed in IN0919WYB2. The levels of viral RNA in clinical samples between pigs infected with IN98COE or IN0919WYB2 were compared. Overall, higher and prolonged expression of viral RNA in pigs infected with IN98COE was observed. However, clinically, IN0919WYB2 was slightly more virulent than IN98COE, as well as more efficient to produce infection through contact transmission. Additionally, infectious virus was recovered from more samples when pigs were infected with IN0919WYB2, as revealed by virus isolation in cell culture, indicating the increased ability of this virus to replicate in pigs. Sequence analyses conducted from isolates recovered from both experimental groups showed that IN0919WYB2 produced more variability during the infection, denoting the potential of this strain to evolve rapidly after a single infection-contact transmission event in pigs. Collectively, the results showed that epidemic strains of VSIV may represent disparate phenotypes in terms of virulence/transmissibility for livestock, a situation that may impact the intensity of an epidemic outbreak. This study also highlights the relevance of pathogenesis studies in pigs to characterize phenotypical differences of VSV strains affecting livestock in the field.
Some Approximation Properties of Two Dimensional Chlodovsky-Bernstein Operators Based on (P, Q) Integer
Authors: Karabıyık Ümit , Karaisa Ali , Ayık Adem
Published: October 2024

In the present study, we introduce the two dimensional Chlodovsky type Bernstein operators based on (p,q)−integer. We examine approximation properties of our new operator by the help of Korovkin-type theorem. Further, we present the local approximation properties and establish the rates of convergence by means of the modulus of continuity and the Lipschitz type maximal function. Also, we give a Voronovskaja type theorem for this operators. And, we investigate weighted approximation properties of these operators and estimate rate of convergence in the same space. Finally, with the help of Maple, illustrative graphics show the rate of convergence of these operators to certain functions . The optimization of approximation speeds by operators during system control provides significant improvements in stability and performance. As a result, the control and modeling of dynamic systems become more efficient and effective through innovative methods. These advancements in the fields of modeling fractional differential equations and control theory offer substantial benefits to both modeling and optimization processes, expanding the range of applications in these areas.
Flood Risk Assessment for the Ancient Sites in Henan Province Considering Multiple types of Materials
Authors: WEN Caihuan , CUI Ximin
Published: October 2024

Presently, the recurrent flood disasters resulting from global extreme weather have inflicted damage upon the Chinese ancient site. Considering the complexity of the materials consist of the Chinese ancient sites, a flood risk assessment method for the ancient sites in Henan province considering multiple types of materials is proposed in this paper. Within the framework, the hazard, sensitivity and vulnerability of the ancient sites are selected and calculated by the selected indicators respectively. To overcome the complexity of the materials, we regard the types of ancient sites as the material score to calculate vulnerability of ancient site. Subsequently, the weight of each indicator is captured based on the analytic hierarchy process (AHP) method. Finally, 157 ancient sites in Henan province are selected for the flood disasters risk calculation and analysis in this paper. The results demonstrate our proposed method can obtain more accurate rainstorm and flood risk of the ancient sites.
Artificial Intelligence in the Non-Invasive Detection of Melanoma
Authors: Ismail Mendi Banu , Kose Kivanc , Fleshner Lauren , Adam Richard , Safai Bijan , Farabi Banu , Atak Mehmet Fatih
Published: October 2024

Skin cancer is one of the most prevalent cancers worldwide, with an increasing incidence. Skin cancer is typically classified as melanoma or non-melanoma skin cancer. Melanoma, despite being much less common than basal or squamous cell carcinomas, is the most deadly, with nearly 8,300 Americans expected to die from melanoma each year. Biopsies are currently the gold standard in diagnosing melanoma; however, they can be invasive and expensive and inaccessible to lower-income individuals. Currently, suspicious lesions are triaged with image-based technologies, such as dermatoscopy and confocal microscopy. While these techniques are useful, there is wide inter-user variability and minimal training for dermatology residents on how to properly use these devices. The use of artificial intelligence (AI)-based technologies in dermatology has emerged in recent years to assist in the diagnosis of melanoma that may be more accessible to all patients and more accurate than current methods of screening. This review explores the current status of the application of AI-based algorithms in the detection of melanoma, underscoring its potential to aid dermatologists in clinical practice. We will specifically focus on AI’s application in clinical imaging, dermoscopic evaluation, algorithms that can distinguish melanoma from non-melanoma skin cancers, and in-vivo skin imaging devices.
Assessment of UV-C Radiation for Bacterial Inactivation of Hydroponic Nutrient Solutions in Dynamic System
Authors: Corrêa Bruna , Perez Shirly Lara , Bagnato Vanderlei Salvador , Blanco Kate Cristina
Published: October 2024

Hydroponics, a soilless cultivation method, is increasingly being adopted for its ability to produce high-quality vegetables while reducing resource usage and minimizing the risks of soil-borne pathogens. However, the reuse of nutrient solutions in hydroponics can accelerate the spread of pathogenic microorganisms. This study aimed to evaluate the bacterial decontamination effects of UV-C light (254 nm) on a hydroponic nutrient solution. The solution was contaminated with Escherichia coli and irradiated with UV-C at energy doses of 20.37 and 489.02 mJ/cm². Experiments were conducted under both static and dynamic fluid conditions to assess bacterial inactivation and changes in electrical conductivity over time. Results showed no significant change in electrical conductivity after 144 hours of UV-C exposure. Under static conditions, bacterial inactivation was observed, with a reduction of 1.7 log CFU/mL at 20.37 mJ/cm², though no significant additional reduction was seen at the higher dose. However, dynamic conditions resulted in greater inactivation, with reductions of 4.2 and 5.2 log CFU/mL at 20.37 and 489.02 mJ/cm², respectively. These findings suggest that fluid agitation plays a crucial role in enhancing UV-C efficiency by preventing bacterial sedimentation, which occurs in static conditions. The use of UV-C as an eco-friendly disinfection method appears promising for hydroponic systems, as it does not alter the composition of the nutrient solution.
The Influence of the GiSelA 5 Rootstock Propagation Method on the Growth and Physiological Parameters of Maiden Trees of Selected Sweet Cherry Varieties
Authors: Świerczyński Sławomir , Schroeter-Zakrzewska Anita
Published: October 2024

The basis of orchard production are rootstocks that reduce the vigor of sweet cherry trees. However, not all rootstocks for this species can be easily propagated using traditional methods by stooling or cutting. Some of these must be propagated using the in vitro culture method. This results in their high price and, consequently, the price of maiden sweet cherry trees. The experiment assessed the growth of maiden trees of selected sweet cherry varieties ('Bellise', 'Earlise', 'Lapins', 'Vanda') depending on the method of the semi-dwarf GiSelA 5 rootstock propagation. Additionally the intensity of life processes taking place in the obtained maiden trees was also examined. One type of this rootstock, obtained by cheaper method from softwood cuttings, was compared with the another propagated using the in vitro method. There were no significant differences in the percentage of maiden trees obtained in both types of rootstocks propagation method and in the two years of study. The efficiency of maiden trees varied little and ranged from 77.43% to 87.74% depending on the factors considered. The vigor of maiden trees growth in the first year of the study was stronger than in the second one. Only the diameter of maiden trees stem varied (from 7% to 39%), depending on the variety considered. With the exception of one variety, maiden trees produced on rootstock propagated from stem cuttings were characterized by a much larger diameter for the three varieties, ranging from 23% to 29% compare to in vitro. Also with this method of propagation, the rootstocks had a better developed root system and the maiden trees had a greater fresh mass. However, most often, no significant differences were found between the methods of propagation, only when comparing the years of research. The activity of life processes of maiden sweet cherry trees varied and no constant regularities were found. The only regularity observed was that maiden trees in the second year of the experiment were more often characterized by lower levels of the tested life parameters (Pn, E, C and Int.CO2), which was associated with worse growth results.
Weight-Bearing CT for Diseases of the Foot
Authors: Chun Dong-Il , Cho Jaeho , Won Sung Hun , Otgonsaikhan Nomkhondorj , Kim Jahyung , Yi Young
Published: October 2024

Since its introduction, weight-bearing computed tomography (WBCT) has gained prominence due to its ability to produce accurate three-dimensional images under natural loading conditions, making it particularly useful for assessing complex foot deformities. This review aimed to focus on the diseases of the foot and categorized the pathological conditions into forefoot disease (hallux valgus), midfoot disease (Lisfranc injuries and midfoot osteoarthritis), and progressive collapsing foot deformity. Owing to its superior diagnostic therapeutic value, WBCT is poised to become the gold standard in foot and ankle imaging.
Time for Care: Male and Female Voices Based on Their Caregiving Experiences
Authors: Ramírez-Perdomo Claudia Andrea , Cantillo-Medina Claudia Patricia , Perdomo-Romero Alix Yaneth
Published: October 2024

Background/Objectives: To understand the lived experiences of the informal caregivers of people with chronic noncommunicable diseases and their interpretations of the significance of that care. The perspectives of men and women interacting with people in a situation of chronicity are examined. Methods: This qualitative phenomenological-hermeneutic study was based on Van Manen’s comprehensive and interpretative vision. Criterion-oriented non-probability random sampling was used. In-depth interviews were used to collect the information. Twenty caregivers participated in the study. Results: The following five themes emerged: transformation of the caregiver’s world; uncertainty of care; tireless guardianship and unwavering devotion; isolation and emotional exhaustion; and imbalance between caring for others and the self. Conclusions: The experience of informal caregivers reveals that both men and women face significant challenges, albeit from gender-differentiated perspectives and experiences. Men and women elaborate different meanings of caregiving, reflecting their gender roles and expectations. Therefore, an inclusive and equitable approach that recognizes and addresses these gender differences is essential in order to improve the support and quality of life for all informal caregivers, respecting and valuing their unique voices and experiences. An inclusive and equitable approach that recognizes gender intersections is required to improve support and the quality of life for caregivers.
Balancing Growth and Sustainability: Real Estate Development in Albania and its Connection to Environmental Sustainability
Authors: Dorri Fabjola , Shahini Besa
Published: October 2024

This study investigates the link between Albania's carbon emissions and various economic factors from 1995 to 2022 to establish the effect of the country’s real estate sector on the environment. Using EViews 12, we assess potential linkages between carbon emission levels, total number of con-struction permits, Gross Domestic Product (GDP), and energy resources. The results indicate the direct relationship between construction permits, economic activities, and carbon emissions, meaning that the current development path does not support environmental sustainability. However, the assessment reveals certain trends to increase the usage of renewable energy accords that may dramatically decrease carbon levels. These results indicate Albanian policymakers' need to adopt regulations supporting sustainability in the real estate market. Promoting investment in renewable energy sources is imperative so far as the Albanian country context is concerned as it is an essential step towards enhancing environmental quality.
New Trends in Communication and Media Education in the Digital Age: A Global Analysis and Comparison Study
Authors: Almakaty Safran Safar
Published: October 2024

The field of communication and media education is constantly evolving, with recent trends emphasizing the development of abstract thinking skills in students. Abstract thinking, crucial for success in the rapidly changing media landscape, involves critical and conceptual analysis of complex ideas. By prioritizing these skills, educators can better prepare students to interpret information creatively and innovatively. Research shows that incorporating abstract thinking methodologies into communication and media curricula enhances problem-solving abilities and creativity. Encouraging students to look beyond surface-level information and consider deeper underlying principles fosters a more adaptable future workforce. This shift towards abstract thinking reflects a broader recognition of critical thinking's importance in our data-driven society. As communication and media increasingly shape public discourse and perception, the need for skilled professionals who can navigate this complex environment is paramount. By integrating abstract thinking strategies into their curricula, educators can equip students with the tools to become more effective communicators, problem solvers, and leaders in the field. This approach is essential for developing professionals capable of navigating the intricate media landscape with sophistication and discernment.
A Comprehensive Achievement in the Total Synthesis of Antibacterial Furanomycin and Its Analogs
Authors: Rohokale Rajendra , Mane Rajendra
Published: October 2024

L-(+)-Furanomycin 1 is a miniature antibacterial natural product that contains an -amino acid core. This non-proteinogenic α-amino acid was first isolated in 1967 by Katagiri and co-workers from the fermentation broth of Streptomyces threomyceticus L-803 (ATCC 15795). It is a substrate of isoleucyl aminoacyl tRNA synthetase that replaces isoleucine in the protein translation process and exhibits antibacterial properties in vitro. It effectively acts as an antibacterial agent against M. tuberculosis, E. coli, B. subtilis, and some Shigella and Salmonella bacterial species at concentrations as low as the micromolar range. Consequently, synthetic chemists have garnered considerable interest from their specific structure-activity profile, distinctive chemical compositions, and distinct biological profile. This review comprehensively describes cutting-edge synthetic methodologies for synthesizing furanomycin and its analogs reported to date. Therefore, this review will offer an initial perspective on synthesizing furanomycin and its customized compounds.
A Network Based Study of the Dynamics of Aβ and τ Proteins in Alzheimer’s Disease
Authors: Bianchi Stefano , Landi Germana , Marella Camilla , Tesi Maria Carla , Testa Claudia
Published: October 2024

Due to the extreme complexity of Alzheimer's disease (AD), the aetiology of which is not yet known, nor are there any known effective treatments, mathematical modelling can be very useful.
Indeed, mathematical models, if deemed reliable, can be used to test medical hypotheses that could be difficult to verify directly.
In this context, it is important to understand how $A\beta$ and $\tau$ proteins, which in abnormal aggregate conformations are hallmarks of the disease, interact and spread. We are particularly interested in this paper in studying the spreading of misfolded $\tau$.
To this end, we present four different mathematical models, all on networks on which the protein evolves. The models differ in both the choice of network and diffusion operator.
Through comparison with clinical data on $\tau$ concentration, that we carefully obtained with multimodal analysis techniques, we show that some models are more adequate than others to simulate the dynamics of the protein.
This type of study may suggest that, when it comes to modelling certain pathologies, the choice of the mathematical setting must be made with great care if comparison with clinical data is considered decisive.
Title Genetic Analysis of HSP70 and HSF3 Polymorphisms and Their Association with Egg Production Traits of Bangladeshi Hilly Chickens
Authors: Ali Md Yousuf , Faruque Shakila , Ahmadi Sadequllah , Ohkubo Takeshi
Published: October 2024

In hot environments, thermoregulation in poultry is regulated by heat shock protein 70 (HSP70), a member of HSPs, and its expression is controlled by the heat shock factor 3 (HSF3). Although the association between genetic polymorphism of these genes and thermotolerance as well as reproductive traits has been extensively studied in mammals but scarce in chickens. This study aimed to explore the relationship between single nucleotide polymorphisms (SNPs) in these genes and egg production traits of Bangladeshi Hilly chickens. To detect new SNPs and perform genotyping, sequencing and allele-specific PCR (AS-PCR) were used. We identified two novel SNPs(G-399A and A-68G) in the 5’-flanking regions of the HSP70 that were significantly associated with higher egg numbers(EN) at 161–190 days and increased egg weight(EW) at 40 weeks of age respectively. Furthermore, SNPs A258G, C276G, and C1431A in HSP70  and A-1388G in HSF3 also existed and were associated with EN at different ages. Haplotype and combined genotypic effects of these two genes were found to be associated with age at sexual maturity(ASM), body weight at ASM, EN, and EW. Identified SNPs and corresponding haplotypes might be useful in selective breeding to enhance the productivity of chickens in hot environments..
Putting the Car Before the Horse: The Diffusion of the Automobile and the Rise of Technocratic Primacy
Authors: Gordon Cameron Elliott
Published: October 2024

This paper reviews the social dimensions of the rolling out and utilization of the automobile in the United States over the past one hundred years, starting with the early days steeped largely (but not exclusively) in technological idealism; moving through an age of car-ascendancy with its peak in the 1950s and 1960 (with the birth of a literal “car culture”); and into the present day of automobile dependency in the midst of a profound changes in auto technology that have unclear societal implications. This review generally indicates that the machine, rather than the human operator, was from early on the center of the creation of a car-based system in America which effectively made the human being and society a reactor to technical progress rather than the other way around. The technological and mechanical aspects of automobiles remain impressive. But the history reviewed here shows that while technical advances are good, these should be guided and channeled into the pursuit of and service to more enlightened and humanist applications, and that such guiding did not happen naturally with the automobile.
A Hybrid Photo-Catalytic Approach Utilizing Oleic Acid-Capped ZnO Nanoparticles for the Treatment of Wastewater Containing Reactive Dyes
Authors: Alhashem Zakia H. , Farha Ashraf H , Aleithan Shrouq H. , Mansour Shehab A. , Tony Maha A.
Published: October 2024

In pursuit of overcoming Fenton’s oxidation limitations in wastewater treatment, an introduction of heterogeneous photocatalyst is developed. In this regard, the current work is introducing ZnO nanocrystals that were successfully prepared by thermal decomposition technique and then capped with oleic acid (OA). The synthesized ZnO-OA and the pristine ZnO were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FE-SEM). Then, the study introduces the application of such materials in advanced oxidation processes, i.e. Fenton's reaction to treat dye-containing wastewater. Synthetic wastewater that prepared using Reactive Blue 4 (RB4) is used as a simulated textile wastewater effluent. Fenton’s oxidation is applied, and the system parameters were assessed using the modified Fenton’s system. The synthesized samples of ZnO are characterized by a recognized wurtzite hexagonal structure. Modifying the surface of ZnO with oleic acid (OA) led to an increase in crystallite size, lattice parameters, and cell volume. These modifications are linked to the efficient capping of ZnO nanoparticles by OA, which further improved the dispersion of the nanoparticles, as demonstrated by SEM imaging. The optimum conditions of ZnO and ZnO-OA synthesized modified Fenton composites showed 400, 40 mg/L for H2O2 and catalyst respectively, at pH 3.0 within 90 min under UV irradiation for maximal dye oxidation reached 93%. The catalytic performance at its optimal circumstances was in accordance with a pseudo-second-order kinetics model for both ZnO-OA and the pristine ZnO based Fenton’s systems. Also, the thermodynamic parameters were also checked and the values settled that both Fenton systems are spontaneous in nature, proceeds at a low energy barrier condition (10.38 and 31.38 kJ/mol for ZnO-OA and the pristine ZnO based Fenton reaction, respectively).
Vacuum Freeze-Drying of Camel and Mare Milk: Process Optimization and Quality Preservation
Authors: Rakhmatulina Ayaulym Bagdatovna , Dikhanbayeva Fatima Toktarovna , Tlevlessova Dinara Abayevna , Abuova Altynai , Aralbayev Nurbek , Yessenova Aidana , Ibraikhan Akniyet Tolegenkyzy
Published: October 2024

The freeze-drying of camel and mare milk presents challenges due to their unique compositions, such as high lactose and protein content. This research aims to optimize vacuum freeze-drying parameters, including temperature, drying time, and layer thickness, for enhanced product quality and reduced energy consumption. Ultrasound and homogenization techniques were applied to enhance moisture transfer during drying. Experimental data suggest optimal conditions of -50°C to +50°C over 22–24 hours, significantly improving reconstitution quality. Mathematical modeling in Python and Maple helped refine process parameters to achieve desirable product consistency.
The Combination of Spray-Drying and Spray-Chilling Techniques to Encapsulate Chasteberry (Vitex agnus castus L.) Extract: Characterization of the Particles and Its Application in Dark Chocolate
Authors: Barrientos Mariana Alejandra Echalar , Peralta Juliana , Tulini Fabricio Luiz , Sá Samuel Gomes de , Chalella Mazzocato Marcella , Trindade Marco Antônio , Luccas Valdecir , Favaro-Trindade Carmen
Published: October 2024

The extract of the fruit chasteberry has phytotherapeutic effects, making it an important ally in women's well-being during premenstrual syndrome (PMS); however, it contains alcohol in the composition, has a bitter taste and spicy flavor, and can also cause a burning sensation. Encapsulation techniques can minimize these problems. In this context, the present study aimed to encapsulate the concentrated extract of chasteberry and develop dark chocolate with the potential for minimizing PMS symptoms by adding 2.5% free or microencapsulated chasteberry extract in the chocolate bar formulation. Microparticles loaded with chasteberry extract were produced by spray drying and covered by spray-chilling using Arabic gum and vegetable fat as the carriers, respectively. The particles were characterized by morphology, size, X-ray diffraction, TGA, and stability of total phenolics and casticin – the molecule responsible for phytotherapeutic effects-. The best particle was added to a dark chocolate mixture. The chocolate samples produced with free and encapsulated extracts were submitted to sensory trials. The two paired comparison tests proved that particles efficiently for masking the chasteberry extract burning sensation and bitterness in the chocolates. Besides, particles were also efficient in protecting casticin. In this context, the encapsulation using the combination of both techniques was efficient in promoting casticin and total phenolics stability and producing chocolate with good sensory aspects. Therefore, it was possible to develop a product that can be used in clinical trials to evaluate its potential to minimize PMS symptoms.
Comparative Analyses of the Complete Mitogenomes of Two Oxyria Species (Polygonaceae) Provide Insights into Understanding the Mitogenome Evolution Within the Family
Authors: Li Lijuan , Jiang Zhuo , Xiong Ye , Akogwu Caleb Onoja , Tolulope Olutayo Mary , Zhou Hao , Sun Yanxia , Wang Hengchang , Zhang Huajie
Published: October 2024

Oxyria (Polygonaceae) is a small genus only comprising two species, Oxyria digyna and O. sinensis. Both species are well-known Chinese herbal medicines with a long history of use. We sequenced and assembled the complete mitogenomes of these two species and conducted a comparative analysis of the mitogenomes within Polygonaceae. Both O. digyna and O. sinensis displayed distinctive multi-branched conformations, consisting of one linear and one circular molecule. These two species shared similar gene compositions and exhibited distinct codon preferences, with mononucleotides as the most abundant type of simple sequence repeats. In the mitogenome of O. sinensis, a pair of long forward repeat sequences can mediate the division of molecule 1 into two sub-genomic circular molecules. Homologous sequence analysis revealed the occurrence of gene transfer between the chloroplast and mitochondrial genomes within Oxyria species. Additionally, a substantial number of homologous collinear blocks with varied arrangements were observed across different Polygonaceae species. Phylogenetic analysis suggested that mitogenome genes can serve as reliable markers for constructing phylogenetic relationships within Polygonaceae. Comparative analysis of eight species revealed Polygonaceae mitogenomes exhibited variability in gene presence, and most protein-coding genes (PCGs) have undergone negative selection. Overall, our study provided a comprehensive overview of the structural, functional, and evolutionary characteristics of the Polygonaceae mitogenomes.
Mosquito‐Borne Disease among Individuals Experiencing Homelessness in the United States: A Literature Review
Authors: Wilke Andre , Hill Megan , Kummer Allisandra , Vasquez Chalmers , Mutebi John-Paul , Huo Xi , Li Han , Chen Jing , Ruan Shigui , Beier John , Litvinova Maria , Byrne Thomas , Ajelli Marco
Published: October 2024

Mosquito-borne diseases are a major public health issue. The United States has experienced mosquito-borne disease outbreaks, including West Nile virus, Zika, dengue, and malaria, highlighting widespread risk across the country. In the United States, exposure to mosquito vectors primarily occurs outdoors. Individuals experiencing unsheltered homelessness are particularly vulnerable to mosquito-borne diseases due to their increased exposure to mosquito vectors, limited access to healthcare, and high prevalence of underlying conditions. This review aims to examine the literature on mosquito-borne disease infections among individuals experiencing homelessness in the United States between 1999 and 2024. Our search strategy used Boolean methods on PubMed, Scopus, and Web of Science to select relevant publications. Two queries were used: the first query focuses on individuals experiencing homelessness and mosquito-borne diseases, and the second one focuses on epidemiological analyses of mosquito-borne disease outbreaks in the US. Only studies reporting at least 1 infection among individuals experiencing homelessness were included. Our search resulted in the identification of 347 studies. After screening them, 8 were ultimately included in this review. Half of the studies identified West Nile virus among individuals experiencing homelessness and the other half reported cases of malaria. These studies show that individuals experiencing homelessness are more exposed to mosquitoes, face a higher risk of infection, and have an increased likelihood of hospitalization due to mosquito-borne diseases compared to the general population. The full extent of mosquito-borne disease exposure among individuals experiencing homelessness remains unclear. With climate change and globalization, there is a consensus in the literature showing an increasing risk of mosquito-borne disease transmission in the next decades, and we have already started to witness this increasing trend. Therefore, we argue that developing policies aimed at providing homeless populations with housing during mosquito-borne disease outbreaks could be instrumental in protecting this segment of the population and promoting health equity.
Insights on Who Funds Climate Change Adaptation Research in South Africa
Authors: Mantlana Brian , Nondlazi Basanda Xhantilomzi , Naidoo Sasha , Ramoelo Abel
Published: October 2024

(1) Background: This article examines the funding landscape of climate change adaptation research in South Africa to understand the origin, distribution, and thematic prioritization of funding for climate-change research in South Africa. (2) Methods: The article used specific search terms to query peer reviewed publications in the Web of Science and Scopus databases (1985 to 2023). (3) Results: Environmental Science emerged as the most dominant research area during this period, while agriculture appeared in the top four position among research areas in climate change adaptation research in South Africa in both databases. The largest number of publications on climate change adaptation research in South Africa is generated through domestic funding, followed by the United States of America, the United Kingdom, and Germany. The National Research Foundation (NRF) had the highest number of publications. The analysis revealed a strong paucity of funding relationship between South Africa and other African countries in the field of climate change adaptation research. (4) Conclusions: Knowledge of these trends can inform policy decisions on funding of climate change adaptation in South Africa and strategic partnerships between South Africa and the rest of the world.
Non-Invasive Measurement for Early Diagnosis of Diastolic Dysfunction among Acute Hypertensive Heart Failure
Authors: Andrianto A , Pratama Ivan Satria , Subagjo Agus , Fatimah Fahrun Nisa’i , Ramadhan Muhammad , Nugraha Ricardo Adrian
Published: October 2024

Objective. This study aimed to determine the correlation of colour M-mode velocity propagation in the assessment of left ventricular diastolic function among acute decompensated heart failure patients with preserved ejection fraction (HFpEF). Materials and Methods. This research is an observational analytical study using a cross–sectional study design conducted from April to June 2022. The subjects of this study were patients diagnosed with acute HFpEF and treated at Dr. Soetomo General Academic Hospital, Surabaya. Patients with heart rhythm disturbances, moderate to severe valvular heart disease, and congenital heart defects were excluded from this study. Patients were measured for diastolic function including mitral valve early mitral inflow velocity (MV E Velocity), mitral peak velocity of early filling (E’) (E' Septal and E' Lateral), left atrial volume index (LAVI), The maximal tricuspid regurgitation velocity (TR V Max), Vp, the ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity (E/E'), the ratio between early and late ventricular filling velocity (E/A) and E/Vp Ratio. N-terminal-pro hormone B-type natriuretic peptide (NT–ProBNP) examination was also performed on study subjects as an additional diagnosis of acute heart failure. Results. There were 33 patients who met the inclusion and exclusion criteria and were included in our study. There were 26 patients (78.8%) with grade I diastolic dysfunction, 4 patients (12.1%) with grade II diastolic dysfunction, and 3 patients (9.1%) with grade III diastolic dysfunction. There is a strong positive correlation between Vp with parameters E' Septal (p = < 0.001; r = 0.636) and E' Lateral (p = < 0.001; r = 0.650). Vp is negatively correlated with the ratio E/E' (p = 0.029; r = –0.37). The PCWP estimate with E/Vp ratio had a strong correlation with the NT–Pro BNP value > 300 pg/ml in acute HFpEF patients (p = < 0.001; r = 0.726) compared to the PCWP estimate with E/E' (p = < 0.001; r = 0.549). Conclusion. There is no correlation between Vp value and degree of diastolic dysfunction in patients with acute HFpEF.
Ad hoc Data Foraging in a Life Sciences Community Ecosystem Using SoDa
Authors: Jamil Hasan M.
Published: October 2024

Biologists often set out to find relevant data in an ever changing landscape of interesting databases. While leading journals publish descriptions of databases, they are usually not current and do not frequently update the list to discard defunct or poor quality database. These indices usually include databases that are proactively requested to be included by their authors. The challenge for individual biologists then is to discover, explore and select databases of interest from a large unorganized collection and effectively use them in analysis without too large an investment. The FAIR data principle being advocated to improve searching, finding, accessing, and inter-operating among these diverse information sources to increase usability is proving to be a difficult proposition and consequently, a large number of data sources are not FAIR compliant. Since linked open data does not guarantee FAIRness, biologists are now left on a solo hunt for information on the open network. In this paper, we propose SoDa, for intelligent data foraging on the internet by biologists. SoDa helps biologists discover resources based on analysis requirements, generate resource access plans, and stores cleaned data and knowledge for community use. A secondary search index is also supported for community members to find archived information in a convenient way.
Analysis of Sea Surface Observation Trajectory Based on the External Coincident Accuracy of Seafloor Geodetic Station Positioning
Authors: Ouyang Yujie , Han Yunfeng , Wang Zeyu , He Yifei
Published: October 2024

Seafloor geodetic station positioning generally uses internal precision to judge the quality of the positioning result, which has many limitations. This paper proposes to use a seafloor geodetic station structure, which can obtain the external coincident accuracy of the acoustic beacon positioning, to evaluate the quality of the observation configuration. The results of the sea trial show that a circular line with a radius of 2 times the depth of the water has an internal precision and an external coincident accuracy of approximately 0.02m; this circular line path also happens to be the best trajectory.
Crosstalk Between Coagulopathy and Inflammation in Obesity-Related Severe COVID-19 Infection
Authors: Talebabadi Nazanin , Mohd Tohit Eusni Rahayu , Abdullah Maha , Zahari Sham Siti Yazmin , Zailan Nur Fatin Zalikha , Amin Nordin Syafinaz , Ismail Irmi Zarina , Gazali Ahmad Mahfuz , Hassan Masriana
Published: October 2024

Obesity is among the most prevalent risk factors in the severe forms of Coronavirus disease 2019 (COVID-19) infection. COVID-19 patients with obesity often face severe complications that might be associated with overexpression of adiponectin, inflammatory cytokines, and angi-otensin-converting enzyme 2 (ACE2) receptors in visceral fat. The pre-existing subclinical in-flammation associated with obesity can also lead to severe inflammatory responses. Elevation of pro-inflammatory cytokines considerably activates coagulation cascades, including the tissue factor (TF) pathway. The hypercoagulable state in COVID-19 is presented by severe pulmonary complications such as venous thromboembolism (VTE), disseminated intravascular coagulation (DIC), and disruption of vascular endothelial cells which can lead to severe complications and death. The interaction between inflammatory response and coagulation mechanism in COVID-19 patients with obesity warrants a further understanding of prognosis and potential therapeutic approaches. This review discussed the crosstalk between inflammation and coagulopathy in obesity-related severe COVID-19 infection.
Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement
Authors: Ha Rira , Cho Won Kyong , Kim Euihyun , Jang Sung Joo , Kim Ju-Duck , Yi Chang-Geun , Moh Sang Hyun
Published: October 2024

The skin, as the body's largest organ, is vital for protecting against environmental stressors, regulating temperature, and preventing water loss. Maintaining a healthy skin barrier is essential for overall skin health and function. We examined the potential of a mixture of five traditional Korean herbal extracts—Cimicifuga racemosa, Paeonia lactiflora, Phellodendron amurense, Rheum rhaponticum, and Scutellaria baicalensis— referred to as herbal medicine composite 5 (HRMC5) for enhancing skin health. High-performance liquid chromatography identified 14 bioactive compounds, including flavonoids, phenolic acids, anthraquinones, and alkaloids, known for their antioxidant, anti-inflammatory, and antimicrobial effects. The extract showed concentration-dependent effects on cell viability and provided UV protection at 6.25 g/L. It also significantly promoted wound healing, similar to the efficacy of epidermal growth factor. Furthermore, the mixture exhibited anti-inflammatory activity by downregulating Cox2 expression and upregulated key skin barrier proteins, including Involucrin, Claudin 1, and Collagen Type 1. These findings highlight the potential of this herbal mixture for addressing skin barrier dysfunction, inflammation, and facial redness, supporting its use in developing natural skincare products. Future studies should investigate the mechanisms behind these effects and assess its clinical applications.