bluuebunny/crossref_metadata_2025 huggingface dataset:
Social innovation in health and community-driven engagement as a key strategy for addressing COVID-19 crisis challenges: insights and reflections from the multicultural society of Iran
Authors: Khazaee-Pool Maryam , Pashaei Tahereh , Ponnet Koen
Published: June 2023

Background

Social innovation is one of the strategies for appealing to people and encouraging social cooperation and engagement in interventions during crisis periods. In this regard, community engagement is an operative and innovative community health approach for achieving successful health outcomes. There is limited information about the role and operational impact of social innovation on community engagement during the challenges posed by the COVID-19 crisis. In this study, we aim to contribute to the understanding of innovative social strategies to attract social participation in crises such as the COVID-19 pandemic by highlighting the experience of social innovative strategies based on community-driven engagement in Iran.

Methods

This qualitative study was conducted in seven provinces of Iran—Mazandaran, Zanjan, Golestan, Lorestan, Tehran, Kurdistan, and Khuzestan—from 4 September 2021 to 1 March 2022. A sample of Iranians (15–71 years) was selected by purposeful and snowball sampling methods to participate in the study, and 187 semi-structured telephone interviews were conducted. Participants were recruited from three levels of the community: community leaders, healthcare providers, and laypeople. The data collection tool was an interview guide, which was designed based on a review of the literature. The data were analyzed using conventional content analysis. Exploratory analyses were performed to identify social innovative strategies based on community engagement used during the COVID-19 crisis in Iran. The interviews continued until data saturation was reached.

Results

Based on our findings, we distilled innovative strategies into 6 main themes and 37 categories: (1) information giving/sharing, (2) consultation, (3) involvement/collaboration, (4) health education and prevention, (5) empowering, and (6) advocacy. The results revealed that the participants were very driven to engage in the management and control of the COVID-19 crisis, even though they faced significant challenges.

Conclusion

The spread of the COVID-19 pandemic required social- and community-based responses. These reactions increased the possibility of fair access to health services, especially for vulnerable groups and minorities. As with other epidemics, applying the experience of the comprehensive participation of communities played an important and active role in the prevention and control of COVID-19. In this regard, giving and sharing information, consultation, involvement/collaboration, health education/prevention, empowerment, and advocacy are the most important innovative strategies that might encourage the community to perform COVID-19 crisis management and control.
Prevalence of myopia among senior students in Fenghua, Eastern China, before and during the COVID-19 pandemic
Authors: Zhou Xuewei , Liu Tong , Wu Aimin , Cheng Bo , Chen Min , Wang Kaijun
Published: June 2023

Background

Myopia is a common cause of vision impairment worldwide. In China, the prevalence, the affected population, and the onset age of myopia are prominent issues. Prevention and intervention of myopia are great public health concerns.

Methods

This school-based retrospective study retrieved visual acuity and refractive data of senior students (grade 12th) from six high schools in Fenghua City, Zhejiang Province, eastern China, from 2016 and 2022. Noncycloplegic autorefraction was performed for refractive status. Students were divided into three subgroups by their school types. The overall myopia prevalence, as well as the prevalence of low myopia, moderate myopia, and high myopia, were calculated separately for each year. Statistical analyzes were performed using SPSS 25.0 and Graphpad Prism software.

Results

The mean myopia prevalence in Fenghua was 84.5% (95% CI: 84.0–85.0%), and a slightly downward trend was found in myopia prevalence after 2019, but the change was not statistically significant (p = 0.078). The overall prevalence of myopia was 79.6, 85.2, and 86.1% in vocational high schools, general high schools, and key high schools, respectively, with statistically significant differences (p < 0.001). The prevalence of myopia among senior students in the vocational high school was significantly lower than that in the other two high schools. There’s no significant change in the overall prevalence of myopia (84.7% vs. 84.3%, p = 0.265) before and during the COVID-19 pandemic, and it remained statistically insignificant after stratifying by gender (male p = 0.207, female p = 0.918) or school types (vocational high school p = 0.112; general high school p = 0.299; key high school p = 0.393).

Conclusion

The prevalence of myopia among senior students in Fenghua is relatively high, and the COVID-19 pandemic has no significant impact on it. The prevalence of myopia among vocational high school students is lower than that of general high school and key high school. Attention should be paid to the effects of educational pressure on the prevalence of myopia among students.
Scoping review of the hardware and software features of virtual reality exposure therapy for social anxiety disorder, agoraphobia, and specific phobia
Authors: Arnfred Benjamin , Svendsen Johanna Kvist , Adjourlu Ali , Horthøj Carsten
Published: June 2023

Introduction: The use of virtual reality technology to deliver exposure therapy in the treatment of phobic anxiety (i.e., social anxiety disorder, agoraphobia, and specific phobia) has been proposed to be advantageous compared with in-vivo exposure therapy. These supposed advantages depend on the features of the virtual reality technology and how it is used therapeutically. Therefore, the aim of this study was to provide a comprehensive overview of the features of the hardware and software used in studies examining virtual reality exposure therapy studies for phobic anxiety disorders.

Methods: 70 studies using virtual reality exposure therapy to treat social anxiety disorder, agoraphobia and/or specific phobia, were systematically reviewed for 46 data points relating to these features.

Results: We found that studies generally did not utilize contemporary virtual reality technology and that hardware and software features were inconsistently delineated.

Discussion: The implications of these findings are that the use of modern virtual reality technology represents a relevant frontier in anxiety treatment and that a framework for reporting technical features of virtual reality exposure interventions would benefit the field.
Ethnography and the digital scenario: a typological scheme of differences and evolutionary trajectories
Authors: Padricelli Giuseppe Michele , Punziano Gabriella
Published: June 2023

The ethnographic method has been a feature of the social sciences since its inception, and for some disciplines, it is markedly characterized by a strong aptitude for physical field research over extended periods in circumscribed communities. However, with the advent of the digital age, this process has undergone further acceleration, upsetting and partly undermining the solid assumptions on which the ethnographic method had been formed, precisely because in the digital scenario, the assumptions of boundaries of contexts, the agency of scenario, and the need for a long-term field investigation change radically. This conceptual analysis aims at providing an overview of the trajectory of the evolution of ethnographic studies in social sciences by trying to trace the main pillars of change and the future direction of the method.
Experimental study on electrostatic migration of different mineral particles composing lunar dust under electron irradiation
Authors: Gan Hong , Wei Guangfei , Zhang Xiao , Xia Guojun , Shi Jingjing
Published: June 2023

Dust electrostatic migration is one of the primary causes of dust events on the surface of airless celestial bodies, which can result in multiple dust phenomena, including lunar horizon glow and dust pools, and also offer crucial insights into the evolution of the surface materials of airless celestial bodies. To date, the characteristics and laws of dust electrostatic migration are still not well understood. Here, we report the electrostatic migration characteristics of pyroxene, olivine, and ilmenite particles measured by the laser Doppler method and compare them with the findings of anorthite particles in previous experiments to recognize the differential migration characteristics of different mineral components in the lunar dust. The results demonstrate that the particle sizes of most moving pyroxene and olivine particles are in the range of 0–10 μm, and their vertical velocities are typically less than 2 m s−1, which are consistent with the previous studies. The cohesive force between the dust particles is probably what causes the difference in the migration rates of various insulating minerals. Note that no moving ilmenite particles were detected probably due to the material’s good conductivity. It can be speculated that the concentration of fugitive dust in the lunar mare is affected by the ilmenite content, but further research is needed to determine how low ilmenite content can cause dust migration.
A New Performance Optimization Method for Linear Motor Feeding System
Authors: Yang Zeqing , Cui Wei , Zhang Wenbo , Wang Zhaohua , Zhang Bingyin , Chen Yingshu , Hu Ning , Bi Xiaoyang , Hu Wei
Published: June 2023

The linear motor feeding system is a typical electromechanical coupling system. Conventional characteristic analyses of electromechanical coupling often overlook the influence of flexible deformation in critical components of the linear motor feeding system. Moreover, when employing genetic algorithms to optimize servo system PID control parameters, slow convergence, nonconvergence, or premature convergence problems may arise. To address these issues, this paper proposes a new performance optimization method for a linear motor feeding system. The method uses a combination of “multi-body theory + finite element” to accurately account for the flexible deformation of critical components of the feeding system, establishes a rigid–flexible electromechanical coupling model of the linear motor feeding system, and optimizes the PID parameters of the established model with an improved adaptive genetic algorithm. Simulation results demonstrate that, when utilizing an adaptive genetic algorithm to optimize the rigid–flexible electromechanical coupling model and a control system model that disregards flexible body deformation, the system achieves stability in 0.02 s and 0.027 s with overshoots of 13% and 27%, respectively. These outcomes confirm the accuracy and importance of considering flexible body deformation in the optimization performance of a linear motor feeding system. At the same time, the time required to reach the steady state of the rigid–flexible electromechanical coupling model optimized by the adaptive genetic algorithm is shortened from 0.035 s to 0.02 s. The sinusoidal signal response curve of the optimized system does not exhibit any peak overshoot compared with that of the nonoptimized system, and the response speed is also faster. These results demonstrate the effectiveness of the rigid–flexible electromechanical coupling model optimized by the nonlinear adaptive genetic algorithm. The displacement response curves of the linear motor feeding system under different workbench loads are obtained through experiments and compared with those obtained from simulations to verify the established model and the correctness of the proposed method.
A Coaxial Pulsed Plasma Thruster Model with Efficient Flyback Converter Approaches for Small Satellites
Authors: O’Reilly Dillon , Herdrich Georg , Schäfer Felix , Montag Christoph , Worden Simon P. , Meaney Peter , Kavanagh Darren F.
Published: June 2023

Pulsed plasma thrusters (PPT) have demonstrated enormous potential since the 1960s. One major shortcoming is their low thrust efficiency, typically <30%. Most of these losses are due to joule heating, while some can be attributed to poor efficiency of the power processing units (PPUs). We model PPTs to improve their efficiency, by exploring the use of power electronic topologies to enhance the power conversion efficiency from the DC source to the thruster head. Different control approaches are considered, starting off with the basic approach of a fixed frequency flyback converter. Then, the more advanced critical conduction mode (CrCM) flyback, as well as other optimized solutions using commercial off-the-shelf (COTS) components, are presented. Variations of these flyback converters are studied under different control regimes, such as zero voltage switching (ZVS), valley voltage switching (VVS), and hard switched, to enhance the performance and efficiency of the PPU. We compare the max voltage, charge time, and the overall power conversion efficiency for different operating regimes. Our analytical results show that a more dynamic control regime can result in fewer losses and enhanced performance, offering an improved power conversion efficiency for PPUs used with PPTs. An efficiency of 86% was achieved using the variable frequency approach. This work has narrowed the possible PPU options through analytical analysis and has therefore identified a strategic approach for future investigations. In addition, a new low-power coaxial micro-thruster model using equivalent circuit model elements is developed.This is referred to as the Carlow–Stuttgart model and has been validated against experimental data from vacuum chamber tests in Stuttgart’s Pulsed Plasma Laboratory. This work serves as a valuable precursor towards the implementation of highly optimized PPU designs for efficient PPT thrusters for the next PETRUS (pulsed electrothermal thruster for the University of Stuttgart) missions.
A Tether System at the L1, L2 Collinear Libration Points of the Mars–Phobos System: Analytical Solutions
Authors: Aslanov Vladimir S. , Neryadovskaya Daria V.
Published: June 2023

This paper is dedicated to identifying stable equilibrium positions of the tether systems attached to the L1 or L2 libration points of the Mars–Phobos system. The orbiting spacecraft deploying the tether is at the L1 or L2 libration point and is held at one of these unstable points by the low thrust of its engines. In this paper, the analysis is performed assuming that the tether length is constant. The equation of motion for the system in the polar reference frame is obtained. The stable equilibrium positions are found and the dependence of the tether angular oscillation period on the tether length is determined. An analytical solution in the vicinity of the stable equilibrium positions for small angles of deflection of the tether from the local vertical is obtained in Jacobi elliptic functions. The comparison of the numerical and analytical solutions for small angles of deflection is performed. The results show that the dependencies of the oscillation period on the length of the tether are fundamentally different for L1 and L2 points. Analytical expressions for the tether tension are derived, and the influence of system parameters on this force is investigated for static and dynamic cases.
Experimental Investigation of Flame Anchoring Behavior in a LOX/LNG Rocket Combustor
Authors: Martin Jan , Börner Michael , Hardi Justin , Suslov Dmitry , Oschwald Michael
Published: June 2023

Hot fire tests of a multi-injector research combustor were performed with liquid-oxygen and liquefied-natural-gas (LOX/LNG) propellants at chamber pressures from 30 up to 67 bar, hence at conditions similar to an upper stage rocket engine. Within these tests shear coaxial injectors were tested with and without a recessed LOX post. In both configurations, operating conditions with flames anchored at the LOX post tip and thus, if available, pre-combustion in the recess volume as well as lifted flames were observed. Flame anchoring was indirectly detected via acoustic measurements, using mean speed of sound to indicate the presence of flame in the head end of the combustion chamber. While the injector without recess showed only stable combustion irrespective of the flame anchoring behavior, the recessed injector featured short-lived bursts of oscillatory combustion and sustained combustion instabilities. Analysis of the test data showed that stable flame anchoring could not be ensured at momentum flux ratios below 20 for a non-recessed and below 45 for a recessed injector.
Developing a Portable Spectrometer to Detect Chemical Contaminants in Irrigation Water
Authors: Zainurin Siti Nadhirah , Wan Ismail Wan Zakiah , Wan Azlan Wan Aina Nadhirah , Zainul Ariffin Khairul Nabilah , Wan Ahmad Kamil Wan Maryam
Published: June 2023

Water pollution is a critical issue since it can severely affect health and the environment. The purpose of the study is to develop a portable spectrometer (ESP32-based spectrometer) to detect chemical contaminants in irrigation water by observing the light absorbance of contaminants. ESP32 and a light sensor (photodiode) were respectively, used as the main controller and detector of the portable spectrometer. It was developed based on optical dispersion and Beer–Lambert law theory. The light absorbance of different types of contaminants was displayed in a Blynk application for real-time monitoring. The samples were also tested using a lab-based spectroscopy method, ultraviolet-visible (UV-Vis) spectrometer. The spectral range of the measurement is from 350 nm to 700 nm and the standard error of the ESP32-based spectrometer is from 0.01 to 0.05. Five water samples were tested, consisting of ammonium nitrate, organic pesticide, zinc oxide and two different reservoirs used for irrigation. The absorption peaks of the ammonium nitrate and organic pesticide are 363 nm and 361 nm, respectively. Zinc oxide shows the absorbance peak at 405 nm, whereas both reservoirs show absorbance peaks lie in the region from 300 nm to 370 nm. Therefore, this study shows that different types of contaminants can absorb light only at specific wavelength regions by considering the concentration of samples. The developed ESP32-based spectrometer can be applied for on-site water quality monitoring as it is portable, light, simple and can be monitored in real time using multiple devices.
Neonicotinoid Sunflower Seed Treatment, While Not Detected in Pollen and Nectar, Still Impacts Wild Bees and Crop Yield
Authors: Ward Laura T. , Hladik Michelle L. , Guzman Aidee , Bautista Ariana , Mills Nicholas J.
Published: June 2023

Neonicotinoid seed treatments are commonly used in agricultural production even though their benefit to crop yield and their impact on pollinators, particularly wild bees, remains unclear. Using an on-farm matched pair design in which half of each field was sown with thiamethoxam treated seed and half without, we assessed honey bee and wild bee exposure to pesticides in sunflower fields by analyzing pesticide residues in field soil, sunflower pollen and nectar, pollen-foraging and nectar-foraging honey bees, and a sunflower specialist wild bee (Melissodes agilis). We also quantified the effects of thiamethoxam-treated seed on wild bee biodiversity and crop yield. M. agilis abundance was significantly lower with thiamethoxam treatment and overall wild bee abundance trending lower but was not significantly different. Furthermore, crop yield was significantly lower in plots with thiamethoxam treatment, even though thiamethoxam was only detected at low concentrations in one soil sample (and its primary metabolite, clothianidin, was never detected). Conversely, wild bee richness was significantly higher and diversity was marginally higher with thiamethoxam treatment. Nectar volumes harvested from the nectar-foraging honey bees were also significantly higher with thiamethoxam treatment. Several pesticides that were not used in the sunflower fields were detected in our samples, some of which are known to be deleterious to bee health, highlighting the importance of the landscape scale in the assessment of pesticide exposure for bees. Overall, our results suggest that thiamethoxam seed treatments may negatively impact wild bee pollination services in sunflower. Importantly, this study highlights the advantages of the inclusion of other metrics, such as biodiversity or behavior, in pesticide risk analysis, as pesticide residue analysis, as an independent metric, may erroneously miss the impacts of field realistic pesticide exposure on bees.
Assessment of the Effects of Fencing Enclosure on Soil Quality Based on Minimum Data Set in Biru County of the Qinghai–Tibet Plateau, China
Authors: Wang Zijia , Jia Lizhi , Yang Linyan , Guo Zihao , Sang Weiguo , Lu Lu , Xiao Chunwang
Published: June 2023

Fencing enclosures play an important role in improving ecological quality. There is a direct impact of implementing fencing enclosures on the change in soil quality. The soil quality index was used to examine the effects of fencing enclosures for different years (7 and 11 years) on soil quality in Biru County of Qinghai–Tibet Plateau, China. The fencing enclosure significantly increased soil water content, non-capillary porosity, soil organic matter, total nitrogen, total phosphorus, and alkali-hydrolyzable nitrogen, and significantly decreased the soil bulk density. The soil quality gradually improved as the fencing enclosure time length increased, probably due to the increase of vegetation coverage and biomass under the fencing enclosure. The minimum data set was composed of soil organic matter, capillary porosity, total potassium, and non-capillary porosity. The minimum data set was significantly correlated with the total data set and could replace the total data set for soil quality evaluation in the fencing enclosure project area. In summary, our study reflects that fencing enclosures significantly improve soil quality, and the implementation of the fencing enclosure project will effectively curb land degradation in Biru County of the Qinghai–Tibet Plateau, China.
Clinical Implications of Immune Checkpoints and the RANK/RANK-L Signaling Pathway in High-Grade Canine Mast Cell Tumors
Authors: Talavera Guillén Noelia C. , Barboza de Nardi Andrigo , Noleto de Paiva Felipe , Dias Queila Cristina , Pinheiro Fantinatti Alexandra , Fávaro Wagner José
Published: June 2023

Mast cell tumors (MCTs) are the most common malignant cutaneous tumors in dogs, and they present extremely variable biological behavior. The interaction between RANK, RANK-L, and immune checkpoints is frequently detected in the tumor microenvironment, and, together, they participate in every stage of cancer development. Thus, the aim of this study was to characterize the molecular profiles of PD-L1, CTLA-4, RANK/RANK-L signaling pathway, and IFN-γ in primary tumors and lymph node metastases. Formalin-fixed, paraffin-embedded slides of MCTs and metastatic lymph nodes of ten dogs were submitted to immunohistochemical investigations. The results demonstrated that the tumor microenvironment of the high-grade mast cell tumors showed moderate or intense immunolabeling of all proteins, and the lymph node metastases also showed moderate or intense immunolabeling of checkpoint proteins. In addition, MCTs larger than 3 cm were associated with intensified PD-L1 (p = 0.03) in metastatic lymph nodes and RANK-L (p = 0.049) immunoreactivity in the tumor. Furthermore, dogs with a survival time of less than 6 months showed higher PD-L1 immunoreactivity (p = 0.042). In conclusion, high-grade MCT is associated with an immunosuppressive microenvironment that exhibits elevated RANK/RANK-L signaling and enhanced immune checkpoint immunoreactivity, potentially facilitating intratumorally immune escape. These biomarkers show promise as clinical indicators of disease progression and might response to immunotherapy in dogs with high-grade MCTs, thus emphasizing their importance for guiding treatment decisions and improving outcomes.
Pharmacokinetic Analysis of Zonarol, a Marine Algal Hydroquinone, in Mice Using HPLC with Fluorescence Detection
Authors: Fei Jiyao , Yamada Sohsuke , Satoh Takumi , Koyama Tomoyuki
Published: June 2023

Zonarol, which was discovered in the brown algae Dictyopteris undulata, has antibiotic, antioxidative, anti-inflammatory, and neuroprotective hydroquinone properties. Additionally, a daily treatment of zonarol taken orally has been proven to prevent ulcerative colitis and nonalcoholic fatty liver disease in experimentally induced mice models. In this study, to elucidate the physiological behavior of zonarol in vivo, the establishment of quantitative methods for the determination of zonarol in biological samples and basic pharmacokinetics parameters after oral or intravenous administration with purified zonarol to mice were investigated. The zonarol (20–600 ng/mL) in this study was dose-dependently detected using an HPLC-FI system as a single peak on the ODS column with 80% aqueous methanol at 332 nm with an excitation of 293 nm. The pharmacokinetic parameters were derived from a non-compartment analysis of the plasma concentration of zonarol following oral or intravenous treatment in mice. The absolute bioavailability of zonarol was calculated as 25.0%. Interestingly, the maximal distribution of zonarol in the brain (2.525 ± 1.334 µg/g tissue) at 30 min was observed to be higher and slower than that in the liver and kidney at 15 min after bolus intravenous administrations to the mice (10 mg/kg BW). Based on these results, zonarol might be a candidate for a potential drug, an effective tool for drug delivery, or enhancing the treatment of cerebral disease.
Investigation of Naphthyl–Polyamine Conjugates as Antimicrobials and Antibiotic Enhancers
Authors: Cadelis Melissa M. , Edmeades Liam R. , Chen Dan , Gill Evangelene S. , Fraser Kyle , Rouvier Florent , Bourguet-Kondracki Marie-Lise , Brunel Jean Michel , Copp Brent R.
Published: June 2023

As part of our search for new antimicrobials and antibiotic enhancers, a series of naphthyl- and biphenyl-substituted polyamine conjugates have been synthesized. The structurally-diverse library of compounds incorporated variation in the capping end groups and in the length of the polyamine (PA) core. Longer chain (PA-3-12-3) variants containing both 1-naphthyl and 2-naphthyl capping groups exhibited more pronounced intrinsic antimicrobial properties against methicillin-resistant Staphylococcus aureus (MRSA) (MIC ≤ 0.29 µM) and the fungus Cryptococcus neoformans (MIC ≤ 0.29 µM). Closer mechanistic study of one of these analogues, 20f, identified it as a bactericide. In contrast to previously reported diarylacyl-substituted polyamines, several examples in the current set were able to enhance the antibiotic action of doxycycline and/or erythromycin towards the Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli. Two analogues (19a and 20c) were of note, exhibiting greater than 32-fold enhancement in activity. This latter result suggests that α,ω-disubstituted polyamines bearing 1-naphthyl- and 2-naphthyl-capping groups are worthy of further investigation and optimization as non-toxic antibiotic enhancers.
Antimicrobial Dispensing Practices during COVID-19 and the Implications for Pakistan
Authors: Gul Bushra , Sana Maria , Saleem Aneela , Mustafa Zia Ul , Salman Muhammad , Khan Yusra Habib , Mallhi Tauqeer Hussain , Sono Tiyani Milta , Meyer Johanna C. , Godman Brian B.
Published: June 2023

Antibiotics are one of the most frequently dispensed classes of medicines. However, excessive misuse and abuse enhances antimicrobial resistance (AMR). Previous studies in Pakistan have documented extensive dispensing of ‘Watch’ and ‘Reserve’ antibiotics, which is a concern. In view of this, there is a need to assess current dispensing patterns following COVID-19 in Pakistan. A cross-sectional study was undertaken, collecting dispensing data from 39 pharmacies and 53 drug stores from November 2022 to February 2023. Outlets were principally in urban areas (60.9%), with pharmacists/pharmacy technicians present in 32.6% of outlets. In total, 11,092 prescriptions were analyzed; 67.1% of patients were supplied at least one antimicrobial, 74.3% antibiotics, 10.2% antifungals and 7.9% anthelmintics. A total of 33.2% of antimicrobials were supplied without a prescription. Common indications for dispensed antibiotics were respiratory (34.3%) and gastrointestinal (16.8%) infections, which can be self-limiting. In addition, 12% of antibiotics were dispensed for the prevention or treatment of COVID-19. The most frequent antibiotics dispensed were ceftriaxone (18.4%) and amoxicillin (15.4%). Overall, 59.2% antibiotics were ‘Watch’ antibiotics, followed by ‘Access’ (40.3%) and ‘Reserve’ (0.5%) antibiotics. Of the total antibiotics dispensed for treating COVID-19, 68.3% were ‘Watch’ and 31.7% ‘Access’. Overall, there appeared to be an appreciable number of antibiotics dispensed during the recent pandemic, including for patients with COVID-19, alongside generally extensive dispensing of ‘Watch’ antibiotics. This needs to be urgently addressed with appropriate programs among pharmacists/pharmacy technicians to reduce AMR.
Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators
Authors: Obrador Elena , Montoro Alegría
Published: June 2023

Ionizing radiation (IR) is the energy released by atoms in the form of electromagnetic waves (e [...]
Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
Authors: Khater Safaa I. , Almanaa Taghreed N. , Fattah Doaa M. Abdel , Khamis Tarek , Seif Mona M. , Dahran Naief , Alqahtani Leena S. , Metwally Mohamed M. M. , Mostafa Mahmoud , Albedair Raghad A. , Helal Azza I. , Alosaimi Manal , Mohamed Amany Abdel-Rahman
Published: June 2023

In the advanced stages of type 2 diabetes mellitus (T2DM), diabetic liver damage is a common complication that can devastate a patient’s quality of life. The present study investigated the ability of liposomal berberine (Lip-BBR) to aid in ameliorating hepatic damage and steatosis, insulin homeostasis, and regulating lipid metabolism in type 2 diabetes (T2DM) and the possible pathways by which it does so. Liver tissue microarchitectures and immunohistochemical staining were applied during the study. The rats were divided into a control non-diabetic group and four diabetic groups, which are the T2DM, T2DM-Lip-BBR (10 mg/kg b.wt), T2DM-Vildagliptin (Vild) (10 mg/kg b.wt), and T2DM-BBR-Vild (10 mg/kg b.wt + Vild (5 mg/kg b.wt) groups. The findings demonstrated that Lip-BBR treatment could restore liver tissue microarchitectures, reduce steatosis and liver function, and regulate lipid metabolism. Moreover, Lip-BBR treatment promoted autophagy via the activation of LC3-II and Bclin-1 proteins and activated the AMPK/mTOR pathway in the liver tissue of T2DM rats. Lip-BBR also activated the GLP-1 expression, which stimulated insulin biosynthesis. It decreased the endoplasmic reticulum stress by limiting the CHOP, JNK expression, oxidative stress, and inflammation. Collectively, Lip-BBR ameliorated diabetic liver injury in a T2DM rat model with its promotion activity of AMPK/mTOR-mediated autophagy and limiting ER stress.
Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-To-45-Year-Old Females: A Cross-Sectional Study
Authors: Šebeková Katarína , Staruchová Marta , Mišľanová Csilla , Líšková Aurélia , Horváthová Mira , Tulinská Jana , Lehotská Mikušová Miroslava , Szabová Michaela , Gurecká Radana , Koborová Ivana , Csongová Melinda , Tábi Tamás , Szökö Éva , Volkovová Katarína
Published: June 2023

Oxidative stress and sterile inflammation play roles in the induction and maintenance of metabolic syndrome (MetS). This study cohort included 170 females aged 40 to 45 years who were categorized according to the presentation of MetS components (e.g., central obesity, insulin resistance, atherogenic dyslipidemia, and elevated systolic blood pressure) as controls not presenting a single component (n = 43), those with pre-MetS displaying one to two components (n = 70), and females manifesting MetS, e.g., ≥3 components (n = 53). We analyzed the trends of seventeen oxidative and nine inflammatory status markers across three clinical categories. A multivariate regression of selected oxidative status and inflammatory markers on the components of MetS was performed. Markers of oxidative damage (malondialdehyde and advanced-glycation-end-products-associated fluorescence of plasma) were similar across the groups. Healthy controls displayed lower uricemia and higher bilirubinemia than females with MetS; and lower leukocyte counts, concentrations of C-reactive protein, interleukine-6, and higher levels of carotenoids/lipids and soluble receptors for advanced glycation end-products than those with pre-MetS and MetS. In multivariate regression models, levels of C-reactive protein, uric acid, and interleukine-6 were consistently associated with MetS components, although the impacts of single markers differed. Our data suggest that a proinflammatory imbalance precedes the manifestation of MetS, while an imbalance of oxidative status accompanies overt MetS. Further studies are needed to elucidate whether determining markers beyond traditional ones could help improve the prognosis of subjects at an early stage of MetS.
Risk Assessment and Water Inrush Mechanism Study of Through-Type Fault Zone Based on Grey Correlation Degree
Authors: Yang Hao , Bian Kai , Wang Tieji , Jin Zidong , Liu Bo , Sun Hui , Chang Junbin
Published: June 2023

In order to effectively prevent and control the problem of water inrush from the through-type fault floor, based on the analysis of the case data of water inrush from the fault structure in the Fengfeng mining area, the types of karst water inrush from the floor are divided into 3 categories, 6 subcategories, and 17 fine categories. Four water inrush modes are summarized: composite structure water inrush, through-type fault water inrush, roof crack expansion water inrush, and floor vertical crack expansion water inrush. Based on the grey correlation theory and combined with the Analytic Hierarchy Process (AHP), this paper evaluates the water inrush risk of the F55-1 through-type fault zone from a micro individual perspective, taking the Xin’an Mine as the engineering background. Based on the water–rock coupling theory, the FLAC3D numerical simulation software is applied to study the disaster mechanism of the water inrush mode of the through-type fault. Through analyzing the changes of primary fracture stress and displacement of the intact floor strata and the aquifuge, and the pressure changes of confined water in fault zones, the collaborative water inrush mechanism of the damage and fracture of the bottom plate rock layer, the expansion and connection of the original fracture, and the seepage and progressive intrusion of the pressure water during the advancing process of the working face is analyzed. The research results indicate that the evaluation result of the water inrush risk of the F55-1 through-type fault in Xin’an Mine is Level I, belonging to the high risk and consistent with the actual situation model, verifying the rationality of the evaluation model. The process of water inrush in the numerical model is summarized as follows: a rock pressure failure zone is caused by the rupture and instability of floor aquifuge; a progressive intrusion zone develops—water inrush is connected between rock pressure failure zone and progressive intrusion zone; floor lagging flood occurs. Under the combined action of mine pressure and confined water pressure, the progressive intrusion height of confined water is significantly increased. The research results have important reference basis for future coal mining planning. This provides engineering reference and practical experience for the prevention and control of water damage in structured bottom plates under similar conditions.
A Malware Detection and Extraction Method for the Related Information Using the ViT Attention Mechanism on Android Operating System
Authors: Jo Jeonggeun , Cho Jaeik , Moon Jongsub
Published: June 2023

Artificial intelligence (AI) is increasingly being utilized in cybersecurity, particularly for detecting malicious applications. However, the black-box nature of AI models presents a significant challenge. This lack of transparency makes it difficult to understand and trust the results. In order to address this, it is necessary to incorporate explainability into the detection model. There is insufficient research to provide reasons why applications are detected as malicious or explain their behavior. In this paper, we propose a method of a Vision Transformer(ViT)-based malware detection model and malicious behavior extraction using an attention map to achieve high detection accuracy and high interpretability. Malware detection uses a ViT-based model, which takes an image as input. ViT offers a significant advantage for image detection tasks by leveraging attention mechanisms, enabling robust interpretation and understanding of the intricate patterns within the images. The image is converted from an application. An attention map is generated with attention values generated during the detection process. The attention map is used to identify factors that the model deems important. Class and method names are extracted and provided based on the identified factors. The performance of the detection was validated using real-world datasets. The malware detection accuracy was 80.27%, which is a high level of accuracy compared to other models used for image-based malware detection. The interpretability was measured in the same way as the F1-score, resulting in an interpretability score of 0.70. This score is superior to existing interpretable machine learning (ML)-based methods, such as Drebin, LIME, and XMal. By analyzing malicious applications, we also confirmed that the extracted classes and methods are related to malicious behavior. With the proposed method, security experts can understand the reason behind the model’s detection and the behavior of malicious applications. Given the growing importance of explainable artificial intelligence in cybersecurity, this method is expected to make a significant contribution to this field.
Biochar Effects on Ce Leaching and Plant Uptake in Lepidium sativum L. Grown on a Ceria Nanoparticle Spiked Soil
Authors: Fellet Guido , Conte Pellegrino , Marchiol Luca
Published: June 2023

The increasing use of nanoparticles is causing a threat to the environment and humans. The aim of this work was to evaluate the effects of the quenching procedure of biochar production on the biochar capacity to retain the CeO2 nanoparticle (CeO2NP) in soil. The effects on Lepidium sativum L. (watercress) were considered. Two biochars were produced from fir wood pellets under the same pyrolysis conditions but with different quenching procedures: dry quenching and wet quenching. The two biochars (BCdryQ and BCwetQ) were separately added to a CeO2NP-spiked soil (1000 mg kg−1) at the dose 5%DW and placed in 12 lysimeters under controlled conditions. Lepidium sativum L. seeds were sowed on each lysimeter. The lysimeters were irrigated once a week for 7 weeks, and the leachates were collected. At the end of the experiment, the aboveground biomass was harvested; the total number of plants and the number of plants at the flowering stage were counted, and the height of the tallest plant and the total dry biomass were measured. The data showed that the quenching procedure influences the CeO2NP retention in soil, and BCdryQ can reduce the leaching of the nanoparticles. Biochar significantly increased the flowering in plants, and BCwetQ reduced the biomass production. This work highlights the importance of the biochar production process for soil applications. The production settings are crucial in determining the efficacy of the product for its ultimate use.
3D Reconstruction of Celadon from a 2D Image: Application to Path Tracing and VR
Authors: Kim Seongil , Park Youngjin
Published: June 2023

We present a straightforward approach for reconstructing 3D celadon models from a single 2D image. The celadon is a historical example of the surface of revolution. Our approach uses a surface of revolution technique to generate the basic shape of the celadon and then applies texture mapping to create a realistic appearance. The process involves detecting the contour and corners of the celadon image, determining an axis of revolution, generating a profile curve, and finally constructing a 3D celadon model. Additionally, we create models as triangular meshes at multiple resolutions, employing a B-spline curve as the profile curve. It enhances the adaptability of the models for various purposes. We render various scenes using a path tracer to assess the suitability of the generated 3D celadon models and generate a VR celadon museum with the models. Overall, our approach offers a simple and efficient solution for reconstructing a 3D celadon model, generating VR content, and demonstrating extensive applicability across numerous disciplines.
Towards a New Paradigm for Digital Health Training and Education in Australia: Exploring the Implication of the Fifth Industrial Revolution
Authors: Pang Toh Yen , Lee Tsz-Kwan , Murshed Manzur
Published: June 2023

Digital transformation, characterised by advanced digitalisation, blockchain, the Internet of Things, artificial intelligence, machine learning technologies, and robotics, has played a key role in revolutionising various industries, especially the healthcare sector. The adoption of and transition (from traditional) to new technology will bring challenges, opportunities, and disruptions to existing healthcare systems. According to the European Union, we must pursue both digital and green transitions to achieve sustainable, human-centric, and resilient industries to achieve a world of prosperity for all. The study aims to present a novel approach to education and training in the digital health field that is inspired by the fifth industrial revolution paradigm. The paper highlights the role of training and education interventions that are required to support digital health in the future so that students can develop the capacity to recognise and exploit the potential of new technologies. This article will briefly discuss the challenges and opportunities related to healthcare systems in the era of digital transformation and beyond. Then, we look at the enabling technologies from an Industry 5.0 perspective that supports digital health. Finally, we present a new teaching and learning paradigm and strategies that embed Industry 5.0 technologies in academic curricula so that students can develop their capacities to embrace a digital future and minimise the disruption that will inevitably accompany it. By incorporating Industry 5.0 principles into digital health education, we believe students can gain a deeper understanding of the industry and develop skills that will enable them to deliver a more efficient, effective, and sustainable healthcare system.
Video-Based Recognition of Human Activity Using Novel Feature Extraction Techniques
Authors: Issa Obada , Shanableh Tamer
Published: June 2023

This paper proposes a novel approach to activity recognition where videos are compressed using video coding to generate feature vectors based on compression variables. We propose to eliminate the temporal domain of feature vectors by computing the mean and standard deviation of each variable across all video frames. Thus, each video is represented by a single feature vector of 67 variables. As for the motion vectors, we eliminated their temporal domain by projecting their phases using PCA, thus representing each video by a single feature vector with a length equal to the number of frames in a video. Consequently, complex classifiers such as LSTM can be avoided and classical machine learning techniques can be used instead. Experimental results on the JHMDB dataset resulted in average classification accuracies of 68.8% and 74.2% when using the projected phases of motion vectors and video coding feature variables, respectively. The advantage of the proposed solution is the use of FVs with low dimensionality and simple machine learning techniques.
Highly Active under VIS Light M/TiO2 Photocatalysts Prepared by Single-Step Synthesis
Authors: Thoda Olga , Moschovi Anastasia M. , Sakkas Konstantinos Miltiadis , Polyzou Ekaterini , Yakoumis Iakovos
Published: June 2023

A single-step impregnation approach is investigated as a synthetic route for photocatalyst synthesis active under visible light. The as-derived photocatalysts exhibited very high degradation rates towards methylene blue (MB) decolorization under visible light despite the high concentration of the initial MB solution concentration. The TiO2-based photocatalysts were prepared using nitrate precursor compounds for copper and silver; thus, Ag/TiO2 and Cu/TiO2 photocatalysts were prepared. The photocatalyst’s physicochemical properties were determined by XRF, BET, and XRD analysis. The metal nature of the titania substrate, the titania matrix effect, and the metal concentration parameters were studied, while the catalyst concentration in the MB initial solution was optimized.
Actinidia arguta (Baby Kiwi) Waste: Preliminary Considerations on Seed Recovery
Authors: Giuggioli Nicole Roberta , Peano Cristiana , Brondino Luca
Published: June 2023

Fruit seed oils are of new interest due to their significant properties and can be a good opportunity to recover fruit waste. Actinidia arguta (baby kiwi) fruits are a novelty in the market and berries can be consumed with the peels. Due to their limited shelf life, fruits are very perishable and the waste management techniques used post-harvest are an important issue. Berry waste can be reused, for biological flows focused on food losses and waste reduction. Therefore, baby kiwi fruit samples were collected from the Ortofruititalia company orchards in Cuneo, Italy, and then processed and analysed for seed oil constituents using standard analytical methods. The results of this study indicate that unsaturated fatty acids were the most dominant fatty acids (92.6 g/100 g) in comparison with saturated (7.4 g/100 g). In addition, α-linoleic acid (82.7 g/100 g) was the most dominant unsaturated fatty acid. Additionally, γ-Tocopherol (0.023 g/100 g) was the most dominant tocopherol in this study. Extraction of seed oil from these berries could be proposed as an option for obtaining high-added-value oils for pharmaceutical cosmetics, among other uses.
Ultra-Precision Cutting Mechanism of KDP Crystal in Microplastic Region via Heating Assistance
Authors: Yang Hong , Fu Siyuan , Huang Ming , Cao Zhonghao , Wang Baorui , Yang Guangwei , Jiang Zhong
Published: June 2023

The application range of potassium dihydrogen phosphate (KDP) crystals can be expanded by enhancing their surface quality properties. Therefore, a method for controlling the surface-temperature field of various materials was developed to expand the plastic zone to overcome the difficulty in processing KDP crystals. The ductile/brittle transition depth of the KDP crystals was determined using a 38 nm nanoindentation experiment. The nanoscratch experiment revealed the rules of how the transformation depth of the KDP crystals changes with temperatures, and the effect of temperature on the microstructure of the KDP crystals was studied. Finally, KDP crystal surfaces were processed using a UPDFC machine at elevated temperatures. According to our experiments, the surface roughness of the KDP crystal reached 5.275 nm as temperature increased, thus enhancing its surface quality. This method could be applied to other brittle materials.