bluuebunny/crossref_metadata_2025 huggingface dataset:
In-silico Analysis of Adenosine Deaminase: From Gene Sequence Retrieval to Clinical Implications and Drug Targets
Authors: Shan Fazal , Ali Sajid , Khan Hassan , Ali Hamza , Rahat Awais , Ullah Rafi
Published: March 2024

Background: Adenosine Deaminase (ADA) plays a critical role in purine metabolism and immune function. Its genetic and molecular characterization is essential for understanding its involvement in various physiological and pathological processes. The ADA gene has been implicated in immune system disorders and offers a potential target for therapeutic intervention.
Objective: This study aims to comprehensively analyze the ADA gene and its protein product, detailing the genetic structure, physiochemical properties, subcellular localization, expression patterns, clinical variations, functional domains, splice variants, and potential as a drug target, to enhance the understanding of its function in human health.
Methods: We utilized an array of in silico tools for gene sequence retrieval, including analysis of genomic databases for ADA's chromosomal location and gene structure. Physiochemical properties were determined using ProtParam, and subcellular localization was predicted with CELLO v.2.5. Gene expression levels across various tissues were ascertained using the Archive Ensemble TOOL. Clinical variations were categorized based on their potential pathogenicity, while splice variants and functional domains were predicted using domain-specific databases. Post-translational modifications were analyzed with prediction tools from the CBS server, and the STRING database facilitated protein interaction network analysis. Additionally, the DoG-Site Scorer predicted ADA's druggability profile.
Results: ADA was localized to chromosome 12 (20q13.12), comprising 45940 base pairs encoding 363 amino acids. The protein's molecular weight was calculated as 37948.09, with a total atom count of 5396. Predictive localization indicated periplasmic and cytoplasmic presence with reliability scores of 1.437*, 1.210*, and 1.058*. Expression profiling revealed high ADA levels in the duodenum, with a notable expression in the lymphatic node. Clinical variations identified included 21 insertions and 23 inversions, with two pathogenic instances. Splice variant analysis predicted nine sites, and drug-binding potential was identified with scores as high as 0.81.
Conclusion: Our study provides a detailed analysis of ADA, highlighting its genetic complexity and biological significance. The identification of clinically relevant gene variations and drug-binding pockets offers potential pathways for therapeutic intervention, emphasizing the importance of ADA in medical research and treatment strategies.
NeuroGenetics of Alzheimer’s Disease: Crosslinking SIRT1 Gene in the Genetic Nexus of Type II Diabetes and Dementia
Authors: Ramzan Muhammad Ikram , Gadi Muhammad Jamal Khan , Shahbaz Hamza , Ashraf Hina , Liaqat Mateen , Hafeez Sana , Sajjad Gufran , Yasin Aqsa
Published: March 2024

Background: Background: Type II Diabetes Mellitus (DM) is a chronic condition that not only affects organ function but also contributes to the development of dementia. SIRT1, a gene implicated in the pathophysiology of Type II DM, has been associated with neurodegenerative processes and cognitive decline.
Objective: This study aimed to evaluate the expression of the SIRT1 gene in patients with Type II DM and dementia, elucidating its potential role as a biomarker for cognitive impairment and neurodegeneration in this population.
Methods: A cohort of 88 diabetic patients with dementia and 12 healthy controls were recruited, and EDTA blood samples were collected. SIRT1 serum levels were quantified using chemiluminescent immunoassay (CLIA). Genomic DNA was extracted and assessed for quality before bisulfite DNA modification and Methylation Specific PCR (MSP) to profile SIRT1 gene methylation. Real-time PCR was conducted to determine SIRT1 gene expression levels. Cognitive function was assessed using Mini-Mental State Examination (MMSE) scores.
Results: The average SIRT1 serum levels in diabetic dementia patients (4.98 ± 1.38 µg/mL) were significantly lower than those in healthy controls (14.21 ± 3.64 µg/mL). MMSE scores mirrored this trend, with patients scoring 12.26 ± 4.56, indicating more considerable cognitive impairment compared to healthy controls' score of 24.1 ± 3.12. SIRT1 gene expression was found to be underexpressed with a fold decrease of approximately 4.1 in dementia cases.
Conclusion: The study's findings highlight the downregulated expression of the SIRT1 gene in diabetic patients with dementia, confirming its potential as a biomarker for cognitive decline. Identifying SIRT1 alterations may provide a non-invasive approach for early diagnosis and management of dementia in the diabetic population.
Apoptosis Response in Acute Lymphoblastic Leukemia Cells after Methotrexate Treatment-A Systematic Review
Authors: Nadeem Syeda Fatima , Chohan Uzma , Mahmood Afaq , Mukhtar Raeesa , Mahmood Usman , Yousaf Zainab , Siddiqi Ammara Hussain
Published: March 2024

Background: Acute lymphoblastic leukemia (ALL) is a malignancy characterized by the overproduction of immature white blood cells in the bone marrow. Methotrexate (MTX) is a cornerstone chemotherapy agent utilized in ALL treatment due to its ability to induce apoptosis in cancerous cells. MTX’s action involves inhibiting dihydrofolate reductase (DHFR), leading to impaired DNA and RNA synthesis, yet resistance to MTX and its exact apoptotic mechanisms remain areas of ongoing research.
Objective: This systematic review aims to elucidate the mechanisms by which MTX induces apoptosis in ALL cells and to assess the clinical implications of these findings for improving therapeutic strategies.
Methods: Adhering to PRISMA guidelines, databases including Google Scholar, Embase, PubMed, and Web of Science were searched for studies published between 2000 and 2023. Studies were included if they involved MTX treatment of ALL cell lines and assessed apoptosis. Critical Appraisal Skills Programme (CASP) tools were used for quality assessment. Data extraction and thematic analysis were employed to synthesize findings.
Results: Twenty-six studies met the inclusion criteria. Key mechanisms of MTX-induced apoptosis included disruption of mitochondrial membrane potential, activation of the JNK signaling pathway, modulation of BCL-2 family proteins, and interference with folate metabolism. Resistance mechanisms and the therapeutic potential of MTX polyglutamates were also identified.
Conclusion: MTX induces apoptosis in ALL cells through multiple pathways, primarily by disrupting folate metabolism and mitochondrial function. The findings reinforce the necessity for personalized approaches in MTX-based therapy, considering the emerging resistance patterns, and highlight the potential of MTX polyglutamates in enhancing treatment efficacy.
Creating Empowerment Communication Model: Case Study Of Community Dialogue Process
Authors: Gemiharto Ilham , Yusup Eka
Published: March 2024

The challenges that communication practitioners face in empowering communities living near multinational companies are significant, especially in ensuring these communities receive their social rights from the profits generated by these companies. Often, mining companies show little concern for the environmental consequences of their exploration activities on affected communities. These qualitative case studies use various research methods, including observation, interviews, document analysis, and descriptive data analysis techniques, with beneficiaries and relevant officials as the primary informants. The core objective of this study is to build a model of communication empowerment through the process of community dialogue. This study focuses on the case of a geothermal exploration project in Kamojang, Garut, using a case study approach to explain the development of an empowerment-oriented communication model through dialogue. This analysis underscores the critical significance of addressing the participatory needs of marginalized communities. Communication models for community empowerment developed near mining company operations are essential in preparing these communities to be self-sufficient, even after the closure of exploration sites. The study not only emphasizes the urgent need to empower communities affected by the company's activities but also showcases practical models for achieving this empowerment through dialogue. It serves as a valuable blueprint for improving communication strategies in the same context, with potentially broader implications in corporate social responsibility and community development practices.
Creative Communication as a Catalyst for Change: Shaping Urban Development Through Psychology and Art
Authors: Razali Geofakta , Mutma Fasya Syifa , Adriana Nadya  Puspita , Angelina Donna , Saldi Zaki Saptari
Published: March 2024

This research discusses the role of creative communication in Indonesia as a catalyst in the formation and development of urban areas. Adopting an interdisciplinary approach that integrates psychology, art, and communication, this study reveals the dynamics between creativity and urban development. Firstly, the research explores the influence of creative design in urban spaces on community psychology and behavior, including the effects of color, shape, and other visual elements. Secondly, a case analysis of art installations and interactive media in public spaces highlights their role as communication tools that enrich urban experiences. Thirdly, the research emphasizes innovation in urban planning that combines creative design and advanced technology. Fourthly, this analysis includes the impact of digital media and social platforms on urban perception, covering the use of social media in urban campaigns. Lastly, the study underscores the importance of community engagement through art and creativity in city development. This research provides evidence that well-designed urban environments can enhance mental health and social well-being.
THE IMPORTANCE OF USING SEDIMENT CHEMISTRY TO INTERPRET ANCIENT MAYA SALT MAKING ACTIVITIES AT THE PAYNES CREEK SALT WORKS
Authors: Sills E. Cory , McKillop Heather
Published: March 2024

Chemical analysis of soils and sediments are useful for finding activities and defining space not readily apparent in the artifact assemblage due to varied preservation. In the Maya cultural area, chemical analysis of anthropogenic and naturogenic terrestrial soils and marine sediments have been used to find activities that occurred at ancient Maya sites both inside and outside of buildings. The Underwater Maya project has adapted soil chemistry, usually conducted at terrestrial sites, to the submerged Paynes Creek Salt Works. The acidic red mangrove peat has remarkably preserved wooden posts that form the outline of buildings and botanical remains but does not preserve bone or shell. The differential preservation at the salt works could obscure the full plethora of activities taking place, under shadowing the complexity of production of salt for the Late Classic Maya. In this paper, we discuss the importance of soil and sediment chemistry analysis in the Maya are, methods for sampling sediment at the Paynes Creek Salt Works, and the chemical signatures of human activity that are most likely to occur at the salt works.
Evaluating the Effect of Coconut Oil Pulling On PlaqueInduced Gingivitis among Young Adolescent Age Group: A Cross Sectional Study
Authors: S Vaishnavi , P Soundarya , Ammu Thomas Pallavi
Published: March 2024

Ayurveda medicines which is based on plantsare used for millennia for treatment of a variety of diseases which includes periodontal diseases. Most of the herbal mouthwashes have been showing positive results like reducing inflammationand bleeding of the periodontal ligament. Thisclinical study’s objective was to evaluate the efficacy of a conventional oil pulling method which uses coconut oil for the treatment of the gingivitis induced by plaque. Materials and Methods: In this study thirty-five agematched individuals (nineteen–twentyone years old) with gingivitis caused by plaque were selected. All registered participants are advised to use five millilitres of edible coconut oil for a five-minute oil pull every morning, on an empty stomach, shortly before brushing their teeth. At baseline, the fifteenthandthirtythday clinical indications such as gingival and plaque index scores were regularly evaluated. SPSS software version was utilized to analyze the data using the student paired t-test. Result:Throughout the trial period, afterpulling with coconut oil there was no unfavorable side effects reported by any of the study participants From the baseline, the fifteenth and the thirtythday, it showed a progressive and statistically significance decrease in plaque and gingival index of pre-treatment and post-treatment scores (P < 0.0001). Conclusion: Plaque production and the ensuing plaqueinduced gingivitis can be reduced by pulling using coconut oil as a supplementary tool for hygiene of oral cavity
Reference Ranges and Gender Differences in Blood Parameter Establishment at Dental Institutions: A Prospective Study
Authors: Sridevi Beeraka Swapna , Putta Pratima , SarathPrathi Venkata
Published: March 2024

Gender differences in haematological variables were shown to be considerable in the majority of these research; as such, determining this difference and estimating the population’s reference range are crucial. The goal of the current study was to establish a range of comparison for the general population as well as to evaluate the haematological variations in several blood parameters between males and females. MATERIAL AND METHODOLOGY: The research was organised on a total of 250 patients with 125 males (50%) and 125 females (50%) in the haematology laboratory of the institution. 20 µl of capillary blood obtained by puncturing the skin over a finger was introduced into 100 µl of diluent. The contents of diluent are sodium sulfate, sodium chloride, a buffering agent, EDTA, formaldehyde, 1pyridone-2-sulphur a with pH of the 6.2-7.6. RESULTS: The study shows that the mean values of Red blood cells, Haemoglobin, Haematocrit, Mean corpuscular volume and Mean corpuscular Haemoglobin were statistically substantially reduced in men compared to females (p < 0.001), and that the mean values of MCHC were considerably lower in females than in males (). PLT and PCT, two haematological markers, were marginally higher in females than in men, with statistically significant findings at p < 0.05. CONCLUSION: Compared to only reporting cell counts, the CBC provides a wealth of detailed information about every blood cell. Even if there are new molecular analysis-based diagnostic and prognostic techniques available today, it’s still crucial to recognize the significance of the tests that doctors have been prescribing for decades. Our research would contribute to the updating of current data on blood variables, their reference range, and gender variance at the regional level.
Simulation of the system of socially oriented personnel management of highly adaptive enterprises
Authors:   Poltava State Agrarian University, Ukraine, Dyachkov Dmytro , Skrypnyk Viktoriia ,   Luhansk Taras Shevchenko National University, Poltava, Ukraine, Yanechko Serhii ,   Kyiv National University of Technologies and Design, Ukraine
Published: March 2024

With the help of game theory, the size of the optimal monetary incentive was investigated depending on the type of additional payments on the example of specific highly adaptive enterprises in the context of socially oriented personnel management. The strategy for the development of enterprises at different levels of management, which under any external conditions will provide an opportunity to obtain even a minimal, but guaranteed profit, has been determined.
Monitoring of local requirements, needs and expectations of young people in creating an international network of virtual youth business hubs
Authors:   Kyiv National University of Technologies and Design, Ukraine, Tsalko Tetiana , Olshanska Olexandra ,   Kyiv National University of Technologies and Design, Ukraine, Nevmerzhytska Svitlana ,   Kyiv National University of Technologies and Design, Ukraine
Published: March 2024

The article highlights the problems of education during the period of war in Ukraine. The idea of the grant project ERASMUS+ Call [ERASMUS-EDU-2022-VIRT-EXCH] – Virtual Exchanges in Higher Education and Youth – “International Network of Virtual Youth Business Hubs” (VEHUB4YOU) is presented. The VEHUB4YOU project focuses on the transfer of business knowledge from the EU to young people in Eastern partner countries through virtual exchange technologies as a means of improving and strengthening the educational process for Ukrainian children who are internally or externally displaced as a result of Russia’s military aggression in Ukraine. The article presents the results of a survey of young people, namely: students and teachers of schools, universities and colleges from Ukraine and Azerbaijan. The survey is dedicated to the determination of the need and interest of students in the creation of an international network of virtual youth business hubs with the aim of improving the quality of education by providing access to modern European education, transfer of business knowledge from the EU to the youth of Eastern partner countries using virtual exchange technologies, etc. The authors of the article summarized the most popular international virtual mobility courses for young people as a result of a survey.
Managing Humans in an Organization
Authors: Murthy G.V.R.
Published: March 2024

Human Resource is one of the most important and dynamic capital in the growth of an organization. Any organization that is interested in improving its services and its effectiveness needs to develop its employee competencies to perform the required tasks. Only those organizations which have optimally utilized their human resources enjoy a competitive edge. Today, best-led, value-driven organizations derive an increasing proportion of their value from the collective power of their intangible assets, which centres around people. Investments on human resources has to be a continuous process, and the nature of investments put into developing human resources may vary from organization to organization depending on its size and capacity. An industry to maintain its competitive advantage must adopt a professional and a committed approach in the management of its human resources. In this era of globalization, with changing technology, new industrial relations, changing demographics of workforce, increasing size of business, larger volumes of production, cutting down costs of production, improving the quality of product necessitates the Indian industry to look inward for the development of human resources and design managerial philosophy which is sensitive to human existence. In the development of an organization, human resource has become increasingly important and it has a positive correlation with the company performance. Human resource is one of the key resource from the development to the expansion of business and also an important strategy to promote competitiveness. Therefore, the challenge of the hour for an organization is to create, nurture and optimize available human resource
Predictors of Hypocalcaemia In Post Thyroidectomy Patients
Authors: Amudala Abhiram
Published: March 2024

Thyroid disorders and surgical management for thyroid disorders are more common in any surgeons day to day life. In this modern medical era for every 3 hours one paper was presented about thyroid disorders
ARABIC INSCRIPS ON THE CURRENCY OF THE SAMUDERA-PASAI SULTANATE AND THE 13th TO EARLY 16th CENTURIES OF THE MALACCA SULTANATE
Authors: Gumilar Agung , Nurhayati Fitri , Hidayat Hendi , Musni M. Jailani , Supardi Adi
Published: March 2024

According to a large number of chronicles and records, Islam is thought to have entered Nusantara directly from the Arabian Peninsula as early as the VII century AD. However, the power of Islam as a political entity has not appeared in the region since the end of the XII and XIII centuries AD. The period was marked by the introduction of a number of Arabic-inscribed currencies minted by local Muslim rulers in an effort to propagate the Islamic religion. The method used in this study is a qualitative descriptive method based on the humanities. The purpose of this research is to find out the type of khat (writing style) as well as the context of the terms contained in the currency of the Samudera-Pasai and Melaka sultanates in an effort to uncover the history of the greatness of Samudera-Pasai and Malacca, which are located on the Spice Route.
KEGIATAN BERMAIN MENGGUNAKAN MEDIA PLASTISIN UNTUK MENGEMBANGKAN MOTORIK HALUS ANAK USIA 4-5 TAHUN DI RA PERSIS 38 GANDOK KOTA TASIKMALAYA
Authors: Nurul Aida Depon , Nurhidayah Nisa , Siti Muthmainah Ai , Agustin Mega
Published: March 2024

Abstrak

Motori halus merupakan gerakan tubuh yang melibatkan otot-otot kecil, seperti otot jari tangan dan pergelangan tangan. Kemampuan motorik halus inilah yang menjadi tumpuan paling penting dalam perkembangan anak. Rendahnya perkembangan motorik halus pada anak usia 4-5 tahun yang diakibatkan oleh kurangnya stimulasi dan kerjasama orang tua, itulah yang melatar belakangi dalam penulisan ini. Terdapat masih ada beberapa anak yang belum bisa memegang pensil dengan benar, menggunting, dan menulis di karenakan kurangnya stimulasi dan kurangnya kerjasama dari para pendamping, baik selaku orang tua atau guru. Salah satu media yang dapat digunakan untuk mengembangkan motorik halus anak yaitu dengan media plastisin. Plastisin merupakan mainan yang menarik bagi anak karena dapat dibentuk dan bahannya lunak. Penelitian ini dilakukan dengan tujuan untuk mengetahui bagaimana perkembangan motorik halus anak di RA Persis 38 menggunakan media plastisin. Subjek penelitian ini terdiri dari 15 anak yaitu 10 anak perempuan dan 5 anak laki-laki. Penelitian ini menggunakan metode penelitian kualitatif melalui pedekatan analisis deskriptif yang melibatkan peserta didik, guru dan orang tua. Teknik pengumpulan data melalui observasi, wawancara dan dokumentasi. Data analisis kualitatif dengan dilakukan 2 kali observasi sebelum dan sesudah tindakan kemudian dibandingkan dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa kemampuan motorik halus anak berkembang hingga 46.6 % setelah dilakukan tindakan. Hal ini berarti media plastisin memberikan pengarug terhadap perkembangan motorik halus anak serta mendukung kemampuan literasi anak usia 4-5 tahun.

Kata kunci: Motorik halus, Plastisin
Pengaruh Penggunaan Metode Qiro'ati terhadap Minat Menjadi Hafidz dan Kemampuan Membaca Al-Qur'an
Authors: Fauji Ilan Fahmi
Published: March 2024

Learning to read the Qur'an in a number of Islamic educational institutions has started since a student is in an early age phase. One of the well-known methods of learning to read the Koran in our country is the Qiro'ati method. This study aims to determine the effect of the theory of learning the Qur’an using the Qiro'ati method on the interest in becoming a hafidz and the ability to read the Qur’an which has long been applied at Madrasah Diniyah Jami'atussakinah, Banjar City. The method used in this research is product moment correlation with one independent variable and two dependent variables. The results of the research show that there is a positive and not significant relationship between the qiro'ati method variable (X1) and the variable interest in becoming a hafidz (X2) together with the variable ability to read the Qur'an (Y). This is evidenced by the significance value or p (sig.) = 0.723 > 0.05 and a relationship value of 0.102. It shows. This means that there are other factors that affect the ability of students to read the Qur'an.
Problematika Pembelajaran Bahasa Arab Menggunakan Film Di MTs Al Hikmah Cikoneng
Authors: Yunus Machmud , Nurlatifah Nurlatifah
Published: March 2024

This research aims to find out what problems students face in class VIII at MTs Al – Hikmah Cikoneng when learning Arabic using Arabic film media. In addition, this study aims to look at opportunities and solutions for Arabic teachers to find new methods of teaching Arabic using film media. This study used a qualitative research method with a descriptive approach. Where this research is research that requires information, explanations, and oral information. The research instruments are observations, interviews, and documentation. The results of this study indicate that the problems faced by students when learning Arabic using film are films that are less interesting in terms of animation and graphics, inadequate subtitles, dialogues that are too fast, and mufrodat that are difficult to memorize. In addition, their learning motivation is still low in learning Arabic so that there are still many students who are not fluent in reading Arabic sentences, which causes their listening skills or maharotul istima' to be still relatively low.
KESULITAN SISWA MEMBACA TEKS BAHASA ARAB DALAM PEMBELAJARAN MAHARAH QIRO'AH
Authors: Aini Syarifah , Yunus Machmud , Aminatusshalihah Tiara
Published: March 2024

Students have difficulty reading or understanding the contents of a text in Arabic lessons so that it has an impact on low Arabic learning outcomes. Though the ability to read has a very important role in learning Arabic also in everyday life. This study aims to obtain data about the difficulty factors of VII grade MTs students Ash-Shiddiqin Panaragan in reading Arabic text. This research used descriptive method with qualitative approach. In this study, which is the subject of research is the students of class VII MTs Ash-Shiddiqin Panaragan academic year 2022/2023. The results of the study revealed that the difficulty factors of Class VII students in reading Arabic texts could be classified into two factors. First, internal factors include the ownership experience and language competence of students was low, less interest in reading students, and students motivation is low. Second, external factors, include factors of teachers who lack the mastery of the material, learning methods that are less attractive, the attitude of the teacher in the learning process assessed to be less enthusiastic, lack of instructional media used, the mobility of the position of a teacher in a classroom that is lacking in monitoring student activities, and lack of availability of textbooks.
ANALISIS PENGGUNAAN MEDIA BIG BOOK DALAM MENGEMBANGKAN KEMAMPUAN BERBAHASA ANAK USIA 3-4 TAHUN
Authors: Hidayat Yusuf , Susanti Vina , Muztahidah Dewi , Hajar Siti , Muslihat Ayi Satriani
Published: March 2024

Language is a media for early childhood to express their feelings and experiences and communicate with others around them. This study aims to determine the impact of using big book media to develop the early childhood’s language skills aged 3-4 years. The method used in this study is a qualitative method under a descriptive approach. The results of study showed that the use of big book media empirically improve the early childhood’s language skills. The early childhood’s language skills generally develop at the level of: (1) acquiring new vocabularies, (2) fluency in pronouncing new vocabularies, (3) understanding the meaning of spoken vocabularies, and (4) being able to retell stories told by teachers based on various pictures listed in big book. In addition, the use of big book media also helps other aspects of early childhood’s development, such as: (1) cognitive aspects and (2) art aspects. In conclusion, empirically the use of big book media can help to develop the early childhood’s language skills aged 3-4 years.
ANALISIS PENYEBAB MOTIVASI YANG RENDAH DALAM PEMBELAJARAN BAHASA ARAB DI PONDOK PESANTREN AL MA'ARIF
Authors: Pratama Andy Riski
Published: March 2024

This article discusses the challenges in learning Arabic at the Alma'arif Islamic Boarding School, especially regarding the lack of student motivation. Arabic is considered important in the context of understanding the Koran and Hadith, as well as an integral part of Islamic educational institutions in Indonesia. Despite this, many students face difficulties in motivating themselves to learn Arabic. The research method used is descriptive qualitative, with a focus on student motivation in learning Arabic. The research results show that student motivation varies, influenced by intrinsic and extrinsic factors, as well as internal and external conditions. Students with high motivation show high enthusiasm and involvement, while students with low motivation tend to lack focus and do not complete assignments on time. Analysis causes a lack of student motivation in identifying several factors, including monotonous teaching methods, lack of relevance of material, conditions of facilities and learning environment that are not conducive, as well as lack of support and understanding from the teacher. Apart from that, the absence of awards and recognition for student achievements is also considered a factor in reducing motivation.
Implementación del SGSST para reducir el nivel de riesgo en la empresa molino agroindustria Alexander S.A.C.
Authors: Huaccha Saman Anghelo Fernando , Abanto Aranda Juan Raphael
Published: March 2024

The benefit of an excellent implementation of the Occupational Safety and Health Management System (OSHMS) is reflected in the well-being and quality of work life, the decrease in absenteeism rates due to illness, the reduction of accident and mortality rates due to work accidents and the increase in business productivity, which is why it was decided to implement an OSHMS to reduce the risk level in the company Molino Agroindustria Alexander S.A.C. The research methodology responds to an explanatory level, with a pre-experimental design. After the application of the SGSST, the level of risk in the company decreased, being 50% in the trivial level, 33% in the tolerable level and 17% in the moderate level. Therefore, it is concluded that the Management System reduces the labor risks in the company Molino Agroindustria Alexander S.A.C.
Pengembangan Inovasi Kabupaten Bogor untuk Meningkatkan Indeks Kepuasan Masyarakat Tahun 2021
Authors: Nasution Shinta , Hotmaria Delima
Published: March 2024

Pengembangan inovasi daerah berpotensi untuk meningkatkan Indeks Kepuasan Masyarakat Kabupaten Bogor karena inovasi terkait langsung dengan peningkatan layanan publik, pemberdayaan dan peningkatan kesejahteraan masyarakat. Semakin masyarakat mendapatkan pelayanan dengan baik dan meningkat kesejahteraannya maka akan semakin meningkat pula kepuasan dan kepercayaan kepada pemerintah. Penelitian ini bertujuan untuk memetakan berbagai program inovasi daerah; merumuskan strategi dan agenda pengembangan inovasi daerah dalam rangka mendukung peningkatan Indeks Kepuasan Masyarakat; dan mengidentifikasi faktor-faktor penting dan berpengaruh dalam pengembangan inovasi daerah di Kabupaten Bogor agar mampu mendukung peningkatan Indeks Kepuasan Masyarakat (IKM). Metode penelitian yang digunakan adalah deskriptif evaluatif dengan pendekatan logic model. Hasil penelitian menunjukkan program inovasi daerah Kabupaten Bogor telah berjalan dengan baik terbukti dengan diperolehnya penghargaan nasional dan jumlah inovasi yang relatif besar dengan fokus yang beragam. Tantangan pengembangan inovasi daerah Kabupaten Bogor adalah agar mampu mendukung pencapaian IKM masyarakat yang saat ini masih rendah dan perlu ditingkatkan. Arah pengembangan inovasi daerah Kabupaten Bogor agar mampu mendukung peningkatan IKM adalah dengan mengembangkan inovasi sebagai sebuah kesatuan sistem sehingga mampu membentuk budaya dan ekosistem inovasi yang progresif.
The Effect of Good Corporate Governance (GCG) on Financial Performance with Corporate Social Responsibility (CSR) as an Intervening Variable (Empirical Study on Primary Consumer Sub Sector Companies Listed on The IDX 2018 - 2022)
Authors: Rusda Amalia , Asmedi Syamsul
Published: March 2024

This research aims to examine the influence of Good Corporate Governance (GCG) including institutional ownership and the board of commissioners on financial performance with Corporate Social Responsibility (CSR) as an intervening variable. This research uses financial performance as the dependent variable and Good Corporate Governance as a proxy for institutional ownership and the board of commissioners as the independent variable and Corporate Social Responsibility (CSR) as the intervening variable. This type of research is associative research. This research uses secondary data in the form of annual financial reports originating from the Indonesia Stock Exchange (BEI). The population in this research is Primary Consumer Sub-Sector Companies listed on the Indonesia Stock Exchange 2018-2022. The sampling technique in this research used a purposive sampling method, 7 companies were obtained as research samples. The data analysis technique in this study uses the multiple linear regression analysis method and the data analysis tool in this study uses the Eviews version 12 software program. The results of the study show that GCG and CSR together have a positive effect on the company's financial performance, while the proxies for institutional ownership and the board commissioner is partially insignificant. Likewise, CSR does not have a significant impact on financial performance. In addition, the board of commissioners proxy influences financial performance through CSR as a moderation, while the institutional ownership proxy does not have a similar effect.Keywords: Good Corporate Governance, Institutional Ownership, Board of Commissioners, Corporate Social Responsibility, Financial Performance
Mapping Junior High School Education Facilities in Bogor: A Comprehensive Study
Authors: Qanitah Adilah Mutiara , Aulia Intan Nurul , Hidayat Janthy , Syahbandar Muhamad Yogie , Kintan Diniarrachma , Bin Hamzah Muhammad Shafik Ikhwan
Published: March 2024

Equitable distribution of educational facilities is very important because every citizen has the right to a decent and quality education as mandated in Law No. 24/2007 on minimum standards of educational facilities and infrastructure. Junior high school education is a bridge between elementary school and senior high school to university. This study and mapping of junior high school education facilities in Bogor Regency is intended to identify the distribution pattern and needs of school facilities and infrastructure at the junior high school level in Bogor Regency. The objectives of this study are 1) To identify the distribution pattern of junior high schools in Bogor Regency; 2) Identify the availability of junior high school facilities and infrastructure in Bogor Regency; and 3) Identify the availability of educational service facilities at junior high school level. Based on the data, analysis was conducted using qualitative and quantitative analysis methods. Data processing using the nearest neighbor technique (average nearest neighbor analysis) is to determine the distribution pattern of junior high school education facilities. Meanwhile, to determine the range of services using Geographic Information System (GIS) buffering analysis techniques. so that the results obtained, 1) The distribution pattern of junior high school facilities in Bogor Regency is clustered with a Critical Value (Z-Score) value of -21.829520, a Nearest Neighbor Ratio value of 0.658887 and an average distance between junior high school education facilities of 963.7 meters; 2) The range of services of junior high school facilities in Bogor Regency is dominated by road lanes.Keywords: study, mapping, distribution pattern, education facilities, junior high school.
The Influence of Facebook Social Media on The Spread of Hoax Information on Generation X in Setu Sari Village Cileungsi Subdistrict
Authors: Amanda Devina
Published: March 2024

This study aims to determine whether or not the influence of Facebook social media on the dissemination of hoax information to Generation X in one of the villages that the researchers chose as a sample. This research uses a quantitative approach and uses a quantitative descriptive method. This research was carried out in Setu Sari Village, Cileungsi District with 150 respondents as a sample. The data collection technique in this study was through observation, and distributing questionnaires by print out or via the Google Forms link. This study obtained the final results of the t-test, f-test, and simple regression test with a significance value of 0.790. Significance value 0.05, meaning that there is no influence of Facebook social media on the dissemination of hoax information to generation X in Setu Sari Village. The conclusion is that the majority of respondents actively use the Facebook platform as an intermediary for information and entertainment for respondents. This means that from the results of the respondents' answers, the majority of Facebook social media users with the X generation category have advanced in literacy, or it can be interpreted that the X generation in Setu Sari Village currently has good literacy values in receiving information read or from other people so that it can reduce the spread of information. hoaxes that are widely shared on the platform.Keywords: Social Media, Facebook.
The role of sharia economics in supporting the realization of sustainable development goals and islamic development
Authors: Ariawan Ariawan , Loso Judijanto  , M. Yusuf Bahtiar  , Farida Akbarina  , Muhammad Syafri
Published: March 2024

Environmentally Friendly Sustainable Development or Sustainable Development Goals is a policy program scheme agreed upon by world leaders to reduce poverty, inequality and end the impact of global climate change. This article discusses how the Sustainable Development Goals go hand in hand with Islamic development. The research method used in this literature review is descriptive qualitative. The study results show that the Islamic concept is in line/sustainable with the SDGs goals. Islam also has a way to fight poverty with zakat, fasting, and a simple lifestyle, providing equal rights between women and men and emphasizing that there is no equal position between the two; and orders humans to manage the environment wisely and maintain natural balance. Mobilizing the Islamic masses to help in achieving the SDGs as a form of their devotion to Allah SWT is a challenge for the government, community organizations and academics in socializing the SDGs and Sustainable Science to society and to higher education, especially Islamic religious universities (PTKI).
Analysis of the Influence Between Study Plan, Locus of Control Learning Achievement at BSM 1 High School in 2024
Authors: Roy Andri
Published: March 2024

All learning objects at the high school level should be a concern. Theoretical and practical studies are balanced. Investigation and understanding at the theoretical and practical levels provide an understanding of the various materials of all subjects provided by the school to students. Improved student abilities demonstrated through learning outcomes can certainly be used to adapt and innovate to meet economic, environmental and social needs in an ever-evolving world. This includes addressing the global challenges of climate change and energy constraints by designing processes to maximize the efficient use of the earth's limited resources. Some lessons are practical learning. Learners are trained to conduct simple qualitative and quantitative research both individually and collaboratively on a range of real-world phenomena. Learners learn to find problems, make hypotheses, design simple experiments, conduct experiments, analyze data, draw conclusions and communicate the results of experiments both in writing and orally.
Pemberdayaan dan Pendampingan Masyarakat Pesisir Peduli Mangrove di Kawasan Mangrove Bangko-Bangko, Kabupaten Lombok Barat, Nusa Tenggara Barat
Authors: Firman Ali Rahman  , Misdarti  , Markum  , Suyono  , Reni Retnowathi  , M. Barmawi  , Hanapi  , Wahyu Wijayanti  , Alfian Pujian Hadi
Published: March 2024

Empowering and assisting coastal communities who care about mangroves is one solution in maintaining sustainable coastal ecosystems. One of them is the Bangko-Bangko mangrove area which is vegetation that supports coastal forests. This service method is carried out through a process of mentoring and community empowerment. The results of the service show that it is important to empower and assist coastal communities adjacent to the Bangko-Bangko mangrove ecosystem in Sekotong District to maintain sustainable mangrove conservation. Apart from that, assistance from people who care about mangroves in the mangrove rehabilitation process is very necessary to ensure that the type of mangrove planted is appropriate to its habitat and growth zone so that the planting program can be successful with a high probability.
Peningkatan Kapasitas Guru Biologi Madrasah Aliyah dalam Menyusun Tes Berbasis Higher-Order Thinking Skills (HOTS) Di kabupaten Lombok Tengah
Authors: Suhirman Suhirman
Published: March 2024

Increasing the Capacity of Madrasah Aliyah Biology Teachers in Developing Higher-Order Thinking Skills (HOTS) Based Tests is carried out to increase the capacity of biology teachers and provide knowledge on aspects related to HOTS and its measurement aspects and train teachers, especially at the Madrasah Aliyah and High School levels. to be skilled at preparing HOTS-based questions. The method for implementing service activities is in the form of a workshop held at State High School (SMAN) 2, Jonggat District, Central Lombok Regency, which was attended by 25 biology teacher participants, who came from 12 State Madrasah Aliyah. The methods and techniques of service carried out in this activity through six (6) stages are: socialization, Focus Group Discussion (FGD, conducting a higher-order thinking skills (HOTS) based test preparation workshop for 25 Madrasah Aliyah biology teachers, Central Lombok Regency, conducting assistance in testing HOTS test questions developed in each madrasah, conducting workshops analyzing the results of testing HOTS test questions and making decisions, evaluating and reflecting on the implementation of workshop activities and mentoring. From the results of observations of workshop participants and documents that have been used to carry out assessments among students, it was identified that they were still measuring students' abilities on the LOTS (low order thinking skill) dimension, namely level C1 (knowing), level C2 (understanding), and level C3 (applying). Besides that, the use of KKO (operational verb) was generally still leaning at a low level.
Pelatihan Pengendalian Nyamuk Vektor Demam Berdarah dengan Lethal MosquiTrap Modification (LMM) di Kecamatan Ampenan, Kota Mataram
Authors: Sazali Munawir , Husnul Budiatman Dani  , Muhsinul Ihsan  , M. Harja Efendi
Published: March 2024

The community service was carried out in Ampenan District, Mataram City, West Nusa Tenggara. Larval Monitoring Cadres (Jumantik) as targets or partners for this service activity. The problem faced by partners is the large number of cases of Dengue Hemorrhagic Fever (DBD) in several areas of Ampenan. The solution to conducting outreach and training on the manufacture and use of Lethal MosquiTrap Modification (LMM). Through this activity, it hoped that provide information and skills to target cadres so that they are able to independently make ovitraps as an effort to control the dengue virus vector. The final result of this service is that it is hoped that the community can avoid the dangers of dengue fever. Training activities are carried out in 2 stages, the evaluation is carried out in a separate phase. First, carry out socialization on mosquito traps which was attended by the local RT Head, posyandu cadres and community leaders. Second, training in making mosquito traps called Lethal MosquiTrap Modification (LMM). In this activity, training was provided on making simple mosquito traps and how to apply these traps by the community. The final phase carried out an evaluation process to see the seriousness of residents in using these traps to control the dengue virus vector, namely the Aedes aegypti mosquito.
Peningkatan Kualitas Sumber Daya Manusia Melalui Program Penguatan Literasi Baca Al-Qur’an Anak Di Desa Penimbung Lombok Barat
Authors: Wahid Lalu Abdurrachman , Pujiarohman  , Etty Setiawati
Published: March 2024

The program to improve the quality of human resources through Al-Quran literacy "Ngaji Maghrib" was successfully implemented in Penimbung Village, West Lombok, NTB, with the aim of increasing Al-Quran literacy among children. Through interactive methods, this program improves Al-Quran reading skills, self-confidence, and attachment to religious values. Community support, including parents and religious leaders, ensures the sustainability of this literacy program. Long-term impact measurement and dissemination through social media and community meetings prove the sustainable results of this program. The sustainability phase is realized through local instructor training, ongoing fundraising efforts, and long-term impact monitoring. This program not only has a positive impact on children's Al-Quran literacy, but also opens up opportunities for sustainable learning in the future. The success of the “Ngaji Maghrib” program in Penimbung Village provides an example of how initiatives focused on literacy can bring significant changes to the lives of children and the community. This program provides a positive legacy for the future, strengthens religious values, and forms a generation with strong Al-Quran literacy.
Sosialisasi Pentingnya Air Kaya Hidrogen (AKH) untuk Kesehatan Tubuh di Desa Persil, Kecamatan Batukliang Utara, Kabupaten Lombok Tengah, Nusa Tenggara Barat
Authors: Musparlin Halid  , Adriyan Suhada  , Hardani  , Beny Binarto Budi Susilo  , Yan Reiza Permana  , Alfisahrin
Published: March 2024

One form of activity in health promotion is in the form of socialization that we do. These activities strengthen the skills and abilities of individuals to take action, and the capacity of groups or communities to act collectively to exercise control over the determinants of health. Socialization activities strengthen the skills and abilities of individuals to take action, and the capacity of groups or communities to act collectively to exercise control over the determinants of health. This activity uses lecture, discussion and question and answer methods with residents. The location of the activity was Persil Village, Central Lombok with 25 participants and accompanied by 3 lecturers and 5 students. The results of our socialization show that local residents need solutions to health problems and hope that Hydrogen Rich Water (AKH) is a solution to the disease problems that they and their families are currently facing. The knowledge of the local community is still categorized as low and requires special attention from the local government and stakeholders. Some residents who participated in the activity had a history of their own diseases, such as gastritis, cholesterol, high blood pressure, allergies and some of their families also had a history of certain diseases, such as kidney stones, diabetes, stroke, cancer and so on. Persil villagers gained knowledge about health, especially the differences in various kinds of water consumed daily. The villagers originally thought that all water is the same, but after we provided information about water, the villagers became more understanding and more selective about the drinks they consume daily.