bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring Terminology Consistency in Translated Corpora: Implementation of the Herfindahl-Hirshman Index
Authors: Gašpar Angelina , Seljan Sanja , Kučiš Vlasta
Published: January 2022

Consistent terminology can positively influence communication, information transfer, and proper understanding. In multilingual written communication processes, challenges are augmented due to translation variants. The main aim of this study was to implement the Herfindahl-Hirshman Index (HHI) for the assessment of translated terminology in parallel corpora for the evaluation of translated terminology. This research was conducted on three types of legal domain subcorpora, dating from different periods: the Croatian-English parallel corpus (1991–2009), Latin-English and Latin-Croatian versions of the Code of Canon Law (1983), and English and Croatian versions of the EU legislation (2013). After the terminology extraction process, validation of term candidates was performed, followed by an evaluation. Terminology consistency was measured using the HHI—a commonly accepted measurement of market concentration. Results show that the HHI can be used for measuring terminology consistency to improve information transfer and message understanding. In translation settings, the process shows the need for quality management solutions.
Understanding of Waggle Dance in the Honey Bee (Apis mellifera) from the Perspective of Long Non-Coding RNA
Authors: Feng Wangjiang , Huang Jingnan , Zhang Zhaonan , Nie Hongyi , Lin Yan , Li Zhiguo , Su Songkun
Published: January 2022

The ethological study of dance behaviour has yielded some findings since Karl Von Frisch discovered and interpreted the ‘dance language’ in the honey bee. However, the function and role of long non-coding RNAs on dance behaviour are hardly known until now. In this study, the differential expression patterns of lncRNAs in the brains of waggling dancers and non-dancing bees were analysed by RNA sequencing. Furthermore, lncRNA-mRNA association analysis was constructed to decipher the waggle dance. The results of RNA sequencing indicated that a total of 2877 lncRNAs and 9647 mRNAs were detected from honey bee brains. Further comparison analysis displayed that two lncRNAs, MSTRG.6803.3 and XR_003305156.1, may be involved in the waggle dance. The lncRNA-mRNA association analysis showed that target genes of differentially expressed lncRNAs in the brains between waggling dancers and non-dancing bees were mainly annotated in biological processes related to metabolic process, signalling and response to stimulus and in molecular function associated with signal transducer activity, molecular transducer activity and binding. Nitrogen metabolism was likely implicated in the modulation of the waggle dance. Our findings contribute to further understanding the occurrence and development of waggle dance.
Context Diffusion in Fog Colonies: Exploring Autonomous Fog Node Operation Using ECTORAS
Authors: Nikolopoulos Vasileios , Nikolaidou Mara , Voreakou Maria , Anagnostopoulos Dimosthenis
Published: January 2022

In Fog Computing, fog colonies are formed by nodes cooperating to provide services to end-users. To enable efficient operation and seamless scalability of fog colonies, decentralized control over participating nodes should be promoted. In such cases, autonomous Fog Nodes operate independently, sharing the context in which all colony members provide their services. In the paper, we explore different techniques of context diffusion and knowledge sharing between autonomous Fog Nodes within a fog colony, using ECTORAS, a publish/subscribe protocol. With ECTORAS, nodes become actively aware of their operating context, share contextual information and exchange operational policies to achieve self-configuration, self-adaptation and context awareness in an intelligent manner. Two different ECTORAS implementations are studied, one offering centralized control with the existence of a message broker, to manage colony participants and available topics, and one fully decentralized, catering to the erratic topology that Fog Computing may produce. The two schemes are tested as the Fog Colony size is expanding in terms of performance and energy consumption, in a prototype implementation based on Raspberry Pi nodes for smart building management.
Sedation with Propofol plus Paracetamol in External Cephalic Version: An Observational Study
Authors: Sánchez-Romero Javier , López-Pérez Jesús , Flores-Muñoz Ana Belén , Méndez-Martínez María Josefa , Araico-Rodríguez Fernando , Mendiola-Olivares Jaime , Blanco-Carnero José Eliseo , Falcón-Araña Luis , Nieto-Díaz Aníbal , Sánchez-Ferrer María Luisa
Published: January 2022

Although the influence of neuraxial anesthesia or sedation with remifentanil in external cephalic version (ECV) is widely known, ECV results using propofol have not been previously analyzed. This study aimed to evaluate ECV outcomes when propofol was used. An observational analysis of ECV was performed between 1 January 2018 and 31 December 2020. ECV was accomplished with tocolysis and propofol. One hundred and thirty-one pregnant women were recruited. The propofol mean dose was 156.1 mg (SD 6.1). A cephalic presentation was achieved in 61.1% (80/131) of the pregnant women. In total, 56.7% (38/67) of pregnant women with cephalic presentation at labor had a spontaneous delivery, 26.9% (18/67) had an operative delivery, and an intrapartum urgent cesarean section was performed in 16.4% (11/67). In total, 46 pregnant women (35.9%) were scheduled for an elective cesarean section due to non-cephalic presentation. The emergency cesarean section rate during the following 24 h was 10.7% (14/131). A major ECV complication arose in 15 cases (11.5%). ECV outcomes when propofol was used seems to be similar to those with other anesthetic adjunct, so sedation with propofol could be an adequate option for ECV. More studies are needed to compare its effectiveness with neuraxial techniques.
Family-Centered Early Intervention (FCEI) Involving Fathers and Mothers of Children Who Are Deaf or Hard of Hearing: Parental Involvement and Self-Efficacy
Authors: Dirks Evelien , Szarkowski Amy
Published: January 2022

(1) Background: Studies related to family-centered early intervention (FCEI) for children who are deaf or hard of hearing (DHH) have largely focused on mothers, at the exclusion of fathers. Yet, understanding fathers’ experiences with FCEI is also important and may inform service delivery. The present study explores self-efficacy and involvement with FCEI in both fathers and mothers. (2) Methods: Dutch fathers and mothers completed questionnaires about their parental self-efficacy, involvement in FCEI, perceived support from their primary EI provider, and the impact of raising a child who is DHH on parenting. (3) Results: Both fathers and mothers reported relatively high levels of self-efficacy. Mothers reported higher levels than fathers on some domains of self-efficacy and tended to be more involved in their child’s FCEI than fathers. In fathers, but not mothers, higher levels of self-efficacy were related to higher levels of involvement and higher levels of perceived support. (4) Conclusions: Similarities and differences were found between fathers and mothers in their perspectives on self-efficacy and involvement. This points to potential differences related to their FCEI needs. EI providers need to address both the needs of fathers and mothers to promote optimal development among child who are DHH.
Diminished Endothelial Function but Normal Vascular Structure in Adults with Tetralogy of Fallot
Authors: Goeder Daniel , Oberhoffer-Fritz Renate , Brudy Leon , Willinger Laura , Meyer Michael , Ewert Peter , Müller Jan
Published: January 2022

The life expectancy of patients with Tetralogy of Fallot (ToF) has increased in recent years. As a result, other risk factors with later onset in life are in the focus of patient care. Endothelial function is an early indicator of cardiovascular risk and was investigated along further structural vessel properties. A total of 17 patients (41.7 ± 7.1 years, 8 women) with Tetralogy of Fallot were 1:2 matched for sex with 34 (38.9 ± 8.1 years, 16 women) healthy volunteers. Participants received an assessment of their endothelial function and a structural assessment of the aorta. Patients with ToF showed a reduced endothelial function determined by reactive hyperaemia index after adjusting for age, weight and height (ToF: 1.55 ± 0.31 vs. controls: 1.84 ± 0.47; p = 0.023). No differences in carotid intima-media thickness (cIMT) between the ToF and healthy controls (ToF: 0.542 ± 0.063 mm vs. controls: 0.521 ± 0.164 mm; p = 0.319) were found. Patients with ToF had reduced vascular function compared to healthy subjects. As the structural component is not affected, endothelial dysfunction seems not to have yet manifested itself as a morphological change. Nevertheless, long-term management of these patients should include vascular parameters.
Cholangitis Definition and Treatment after Kasai Hepatoportoenterostomy for Biliary Atresia: A Delphi Process and International Expert Panel
Authors: Calinescu Ana M. , Madadi-Sanjani Omid , Mack Cara , Schreiber Richard A. , Superina Riccardo , Kelly Deirdre , Petersen Claus , Wildhaber Barbara E.
Published: January 2022

(1) Background: Acute cholangitis during the first year after Kasai hepatoportoenterostomy (HPE) has a negative impact on patient and native liver survival. There are no consistent guidelines for the definition, treatment, and prophylaxis of cholangitis after HPE. The aim of this study was to develop definition, treatment, and prophylaxis guidelines to allow for expeditious management and for standardization in reporting. (2) Methods: the Delphi method, an extensive literature review, iterative rounds of surveys, and expert panel discussions were used to establish definition, treatment, and prophylaxis guidelines for cholangitis in the first year after HPE. (3) Results: Eight elements (pooled into two groups: clinical and laboratory/imaging) were identified to define cholangitis after HPE. The final proposed definitions for suspected and confirmed cholangitis are a combination of one element, respectively, two elements from each group; furthermore, the finding of a positive blood culture was added to the definition of confirmed cholangitis. The durations for prophylaxis and treatment of suspected and confirmed cholangitis were uniformly agreed upon by the experts. (4) Conclusions: for the first time, an international consensus was found for guidelines for definition, treatment, and prophylaxis for cholangitis during the first year after Kasai HPE. Applicability will need further prospective multicentered studies.
Mimickers of Large Vessel Giant Cell Arteritis
Authors: Ramon André , Greigert Hélène , Ornetti Paul , Bonnotte Bernard , Samson Maxime
Published: January 2022

Giant cell arteritis (GCA) is a large-vessel granulomatous vasculitis occurring in patients over 50-year-old. Diagnosis can be challenging because there is no specific biological test or other diagnoses to consider. Two main phenotypes of GCA are distinguished and can be associated. First, cranial GCA, whose diagnosis is usually confirmed by the evidence of a non-necrotizing granulomatous panarteritis on temporal artery biopsy. Second, large-vessel GCA, whose related symptoms are less specific (fever, asthenia, and weight loss) and for which other diagnoses must be implemented if there is neither cephalic GCA nor associated polymyalgia rheumatica (PMR) features chronic infection (tuberculosis, Coxiella burnetti), IgG4-related disease, Erdheim Chester disease, and other primary vasculitis (Behçet disease, relapsing polychondritis, or VEXAS syndrome). Herein, we propose a review of the main differential diagnoses to be considered regarding large vessel vasculitis.
Modeling Flexural Failure in Carbon-Fiber-Reinforced Polymer Composites
Authors: Burgani Thiago de Sousa , Alaie Seyedhamidreza , Tehrani Mehran
Published: January 2022

Flexural testing provides a rapid and straightforward assessment of fiber-reinforced composites’ performance. In many high-strength composites, flexural strength is higher than compressive strength. A finite-element model was developed to better understand this improvement in load-bearing capability and to predict the flexural strength of three different carbon-fiber-reinforced polymer composite systems. The model is validated against publicly available experimental data and verified using theory. Different failure criteria are evaluated with respect to their ability to predict the strength of composites under flexural loading. The Tsai–Wu criterion best explains the experimental data. An expansion in compressive stress limit for all three systems was observed and is explained by the compression from the loading roller and Poisson’s effects.
The Influence of Residuals Combining Temperature and Reaction Time on Calcium Phosphate Transformation in a Precipitation Process
Authors: Ghajeri Farnaz , Leifer Klaus , Larsson Anders , Engqvist Håkan , Xia Wei
Published: January 2022

Precipitation is one of the most common processes to synthesize hydroxyapatite, which is the human body’s mineral forming bone and teeth, and the golden bioceramic material for bone repair. Generally, the washing step is important in the precipitation method to remove the residuals in solution and to stabilize the phase transformation. However, the influence of residuals in combination with the reaction temperature and time, on calcium phosphate formation, is not well studied. This could help us with a better understanding of the typical synthesis process. We used a fixed starting ion concentration and pH in our study and did not adjust it during the reaction. XRD, FTIR, ICP-OES, and SEM have been used to analyze the samples. The results showed that combining residuals with both reaction temperature and time can significantly influence calcium phosphate formation and transformation. Dicalcium phosphate dihydrate formation and transformation are sensitive to temperature. Increasing temperature (60 °C) can inhibit the formation of acidic calcium phosphate or transform it to other phases, and further the particle size. It was also observed that high reaction temperature (60 °C) results in higher precipitation efficiency than room temperature. A low ion concentration combining reaction temperature and time could still significantly influence the calcium phosphate transformation during the drying.
Children and Life-Cycle Consumption
Authors: Grant Charles
Published: January 2022

This paper investigates the role of children in explaining the life-cycle pattern of consumption (which is hump-shaped since it is higher in the middle of life and lower at the beginning and end of life). Unlike previous studies, a true panel of U.K. households was exploited to investigate whether currently childless households that anticipate having children behave differently from similar households that do not anticipate children. Spending for each group at different ages was estimated using a simple kernel regression. The paper finds that those households that anticipate children, when compared to households that do not anticipate children, do not seem to significantly reduce total spending before having children, nor do they significantly increase total spending after children arrive. Hence, children do not seem to fully explain the hump shape of consumption over the life-cycle.
Can The ‘Speed Bump Sign’ Be a Diagnostic Tool for Acute Appendicitis? Evidence-Based Appraisal by Meta-Analysis and GRADE
Authors: Wang Ling , Ling Ching-Hsien , Lai Pei-Chun , Huang Yen-Ta
Published: January 2022

Objectives: The ‘speed bump sign’ is a clinical symptom characterised by aggravated abdominal pain while driving over speed bumps. This study aimed to perform a diagnostic meta-analysis, rate the certainty of evidence (CoE) and analyse the applicability of the speed bump sign in the diagnosis of acute appendicitis. Materials and Methods: Four databanks and websites were systemically searched, and the Quality Assessment of Diagnostic Accuracy Studies 2 was used to evaluate the risk of bias. Meta-analysis was assessed by MIDAS commands in Stata 15. Grading of Recommendations, Assessment, Development and Evaluation methodology was applied to examine the CoE. Results: Four studies with 343 participants were included. The pooled sensitivity and specificity were 0.94 (95% CI (confidence interval) = 0.83–0.98; I2 = 79%) and 0.49 (95% CI = 0.33–0.66; I2 = 67%), respectively. The area under the summary receiver operating characteristic curve was 0.78 (95% CI = 0.74–0.81). The diagnostic odds ratio was 14.1 (95% CI = 3.6–55.7). The pooled positive and negative likelihood ratios (LR (+) and LR (−)) were 1.84 (95% CI = 1.30–2.61) and 0.13 (95% CI = 0.04–0.41), respectively. According to Fagan’s nomogram plot, when the pretest probabilities were 25%, 50% and 75%, the related posttest probabilities increased to 38%, 65% and 85% calculated through LR (+), respectively, and the posttest probabilities were 4%, 12% and 28% calculated through LR (−), respectively. The overall CoEs were low and very low in sensitivity and specificity, respectively. Conclusion: Current evidence shows that the speed bump sign is a useful ‘rule-out’ test for diagnosing acute appendicitis. With good accessibility, the speed bump sign may be added as a routine part of taking the history of patients with abdominal pain.
A Rationalization of the Effect That TMAO, Glycine, and Betaine Exert on the Collapse of Elastin-like Polypeptides
Authors: Pica Andrea , Graziano Giuseppe
Published: January 2022

Elastin-like polypeptides (ELPs) are soluble in water at low temperature, but, on increasing the temperature, they undergo a reversible and cooperative, coil-to-globule collapse transition. It has been shown that the addition to water of either trimethylamine N-oxide (TMAO), glycine, or betaine causes a significant decrease of T(collapse) in the case of a specific ELP. Traditional rationalizations of these phenomena do not work in the present case. We show that an alternative approach, grounded in the magnitude of the solvent-excluded volume effect and its temperature dependence (strictly linked to the translational entropy of solvent and co-solute molecules), is able to rationalize the occurrence of ELP collapse in water on raising the temperature, as well as the T(collapse) lowering caused by the addition to water of either TMAO, glycine, or betaine.
Additive Manufacturing of Magnetostrictive Fe–Co Alloys
Authors: Nakajima Kenya , Leparoux Marc , Kurita Hiroki , Lanfant Briac , Cui Di , Watanabe Masahito , Sato Takenobu , Narita Fumio
Published: January 2022

Fe–Co alloys are attracting attention as magnetostrictive materials for energy harvesting and sensor applications. This work investigated the magnetostriction characteristics and crystal structure of additive-manufactured Fe–Co alloys using directed energy deposition. The additive-manufactured Fe–Co parts tended to exhibit better magnetostrictive performance than the hot-rolled Fe–Co alloy. The anisotropy energy ΔK1 for the Fe–Co bulk, prepared under a power of 300 W (referred to as bulk−300 W), was larger than for the rolled sample. For the bulk−300 W sample in a particular plane, the piezomagnetic constant d was large, irrespective of the direction of the magnetic field. Elongated voids that formed during additive manufacturing changed the magnetostrictive behavior in a direction perpendicular to these voids. Magnetic property measurements showed that the coercivity decreased. Since sensors should be highly responsive, Fe–Co three-dimensional parts produced via additive manufacturing can be applied as force sensors.
Effects of Preparation Procedures and Porosity on Thermoelectric Bulk Samples of Cu2SnS3 (CTS)
Authors: Lohani Ketan , Fanciulli Carlo , Scardi Paolo
Published: January 2022

The thermoelectric behavior and stability of Cu2SnS3 (CTS) has been investigated in relation to different preparations and sintering conditions, leading to different microstructures and porosities. The studied system is CTS in its cubic polymorph, produced in powder form via a bottom-up approach based on high-energy reactive milling. The as-milled powder was sintered in two batches with different synthesis conditions to produce bulk CTS samples: manual cold pressing followed by traditional sintering (TS), or open die pressing (ODP). Despite the significant differences in densities, ~75% and ~90% of the theoretical density for TS and ODP, respectively, we observed no significant difference in electrical transport. The stable, best performing TS samples reached zT ~0.45, above 700 K, whereas zT reached ~0.34 for the best performing ODP in the same conditions. The higher zT of the TS sintered sample is due to the ultra-low thermal conductivity (κ ~0.3–0.2 W/mK), three-fold lower than ODP in the entire measured temperature range. The effect of porosity and production conditions on the transport properties is highlighted, which could pave the way to produce high-performing TE materials.
Electrochemical Synthesis of Zinc Oxide Nanostructures on Flexible Substrate and Application as an Electrochemical Immunoglobulin-G Immunosensor
Authors: Patella Bernardo , Moukri Nadia , Regalbuto Gaia , Cipollina Chiara , Pace Elisabetta , Di Vincenzo Serena , Aiello Giuseppe , O’Riordan Alan , Inguanta Rosalinda
Published: January 2022

Immunoglobulin G (IgG), a type of antibody, represents approximately 75% of serum antibodies in humans, and is the most common type of antibody found in blood circulation. Consequently, the development of simple, fast and reliable systems for IgG detection, which can be achieved using electrochemical sandwich-type immunosensors, is of considerable interest. In this study we have developed an immunosensor for human (H)-IgG using an inexpensive and very simple fabrication method based on ZnO nanorods (NRs) obtained through the electrodeposition of ZnO. The ZnO NRs were treated by electrodepositing a layer of reduced graphene oxide (rGO) to ensure an easy immobilization of the antibodies. On Indium Tin Oxide supported on Polyethylene Terephthalate/ZnO NRs/rGO substrate, the sandwich configuration of the immunosensor was built through different incubation steps, which were all optimized. The immunosensor is electrochemically active thanks to the presence of gold nanoparticles tagging the secondary antibody. The immunosensor was used to measure the current density of the hydrogen development reaction which is indirectly linked to the concentration of H-IgG. In this way the calibration curve was constructed obtaining a logarithmic linear range of 10–1000 ng/mL with a detection limit of few ng/mL and good sensitivity.
Fast-Acquiring High-Quality Prony Series Parameters of Asphalt Concrete through Viscoelastic Continuous Spectral Models
Authors: Zhang Yan , Sun Yiren
Published: January 2022

Prony series representations have been extensively applied to characterizing the time-domain linear viscoelastic (LVE) material functions for asphalt concrete. However, existing methods that can generate high-quality Prony series parameters (i.e., discrete spectra) mostly involve complicated programming algorithms, which poses a challenge for quick access of Prony series parameters. Also, very limited research has been devoted to establishing methods for simultaneously determining both retardation and relaxation spectra. To resolve these issues, this study presented a practical approach to fast acquiring high-quality Prony series parameters for both relaxation modulus and creep compliance of asphalt concrete by using the complex modulus test data. The approach adopts the analytical representations of the continuous relaxation and retardation spectra from the Havriliak-Negami (HN) and 2S2P1D complex modulus models to directly determine the discrete spectra, and the elastic constants, Ee and Dg, for both LVE modulus and compliance functions are further calculated by fitting the corresponding generalized Maxwell model representations to smoothed data from the storage modulus representations of the HN and 2S2P1D complex modulus models. In this way, all the procedures in the proposed method can be easily implemented in Microsoft Excel. The results showed that the HN and 2S2P1D models yielded slightly different continuous spectral patterns at shorter relaxation times and longer retardation times. However, at the region covered by the test data, the continuous spectra of the two complex modulus models were very close to each other. Thus, the two models can generate comparable Prony series parameters within the time or frequency range covered by the test data. Considering that the quality of the resulting Prony series parameters are closely related to the master curve models used for presmoothing, the HN and 2S2P1D models were compared with the conventional Sigmoidal model. Additionally, the Black diagram was recommended for examining the quality of the complex modulus test data before constructing the master curves.
Corrosion Resistance of MgO and Cr2O3-Based Refractory Raw Materials to PbO-Rich Cu Slag Determined by Hot-Stage Microscopy and Pellet Corrosion Test
Authors: Ludwig Maciej , Śnieżek Edyta , Jastrzębska Ilona , Prorok Ryszard , Li Yawei , Liao Ning , Nath Mithun , Vlček Jozef , Szczerba Jacek
Published: January 2022

Chemical resistance of commercial refractory raw materials against Cu slag is critical to consider them as candidates for the production of refractories used in Cu metallurgy. In this study, we show the comparative results for the corrosion resistance of four commercial refractory raw materials—magnesia chromite co-clinkers FMC 45 and FMC 57, PAK, and fused spinel SP AM 70—against aggressive, low-melting PbO-rich Cu slag (Z1) determined by hot-stage microscopy (up to 1450 °C) and pellet test (1100 and 1400 °C). Samples were characterized after the pellet test by XRD, SEM/EDS, and examination of their physicochemical properties to explore the corrosion reactions and then assess comparatively their chemical resistance. Since many works have focused on corrosion resistance of refractory products, the individual refractory raw materials have not been investigated so far. In this work, we show that magnesia chromite co-clinker FMC 45 exhibits the most beneficial properties considering its application in the production of refractories for the Cu industry. Forsterite (Mg2SiO4) and güggenite (Cu2MgO3) solid solutions constitute corrosion products in FMC 45, and its mixture with slag shows moderate dimensional stability at high temperatures. On the other hand, the fused spinel SP AM 70 is the least resistant to PbO-rich Cu slag (Z1); it starts to sinter at 970 °C, followed by a fast 8%-shrinkage caused by the formation of güggenite solid solution in significant amounts.
Introduction of a Power Law Time-Temperature Equivalent Formulation for the Description of Thermorheologically Simple and Complex Behavior
Authors: Qiao Linan , Nagelschmidt Sven , Herbrich Uwe , Keller Christian
Published: January 2022

In this work, a conceptual framework is suggested for analyzing thermorheologically simple and complex behavior by using just one approach. Therefore, the linear relation between master time and real time which is required in terms of the time-temperature superposition principle was enhanced to a nonlinear equivalent relation. Furthermore, we evaluate whether there is any relation among well-known existing time-temperature equivalent formulations which makes it possible to generalize different existing formulations. For this purpose, as an example, the power law formulation was used for the definition of the master time. The method introduced here also contributes a further framework for a unification of established time-temperature equivalent formulations, for example the time-temperature superposition principle and time-temperature parameter models. Results show, with additional normalization conditions, most of the developed time-temperature parameter models can be treated as special cases of the new formulation. In the aspect of the arrow of time, the new defined master time is a bended arrow of time, which can help to understand the corresponding physical meaning of the suggested method.
Research Progress on Controlled Low-Strength Materials: Metallurgical Waste Slag as Cementitious Materials
Authors: Liu Yiliang , Su Youpo , Xu Guoqiang , Chen Yanhua , You Gaoshuai
Published: January 2022

Increasing global cement and steel consumption means that a significant amount of greenhouse gases and metallurgical wastes are discharged every year. Using metallurgical waste as supplementary cementitious materials (SCMs) shows promise as a strategy for reducing greenhouse gas emissions by reducing cement production. This strategy also contributes to the utilization and management of waste resources. Controlled low-strength materials (CLSMs) are a type of backfill material consisting of industrial by-products that do not meet specification requirements. The preparation of CLSMs using metallurgical waste slag as the auxiliary cementing material instead of cement itself is a key feature of the sustainable development of the construction industry. Therefore, this paper reviews the recent research progress on the use of metallurgical waste residues (including blast furnace slag, steel slag, red mud, and copper slag) as SCMs to partially replace cement, as well as the use of alkali-activated metallurgical waste residues as cementitious materials to completely replace cement for the production of CLSMs. The general background information, mechanical features, and properties of pozzolanic metallurgical slag are introduced, and the relationship and mechanism of metallurgical slag on the performance and mechanical properties of CLSMs are analyzed. The analysis and observations in this article offer a new resource for SCM development, describe a basis for using metallurgical waste slag as a cementitious material for CLSM preparation, and offer a strategy for reducing the environmental problems associated with the treatment of metallurgical waste.
Laser Structured Dental Zirconium for Soft Tissue Cell Occupation—Importance of Wettability Modulation
Authors: Staehlke Susanne , Oster Philip , Seemann Susanne , Kruse Fabian , Brief Jakob , Nebe Barbara
Published: January 2022

Various approaches are being pursued to physico-chemically modify the zirconia neck region of dental implants to improve the integration into the surrounding soft tissue. In this study, polished zirconia discs were laser microstructured with periodic cavities and convex waves. These zirconia samples were additionally activated by argon plasma using the kINPen®09. The surface topography was characterized by scanning electron microscopy and the surface wettability by water contact angle. The in vitro study with human gingival fibroblasts (HGF-1) was focused on cell spreading, morphology, and actin cytoskeleton organization within the first 24 h. The laser-induced microstructures were originally hydrophobic (e.g., 60 µm cavities 138.4°), but after argon plasma activation, the surfaces switched to the hydrophilic state (60 µm cavities 13.7°). HGF-1 cells adhered flatly on the polished zirconia. Spreading is hampered on cavity structures, and cells avoid the holes. However, cells on laser-induced waves spread well. Interestingly, argon plasma activation for only 1 min promoted adhesion and spreading of HGF-1 cells even after 2 h cultivation. The cells crawl and grow into the depth of the cavities. Thus, a combination of both laser microstructuring and argon plasma activation of zirconia seems to be optimal for a strong gingival cell attachment.
Correlation of Load-Bearing Behavior of Reinforced Concrete Members and Velocity Changes of Coda Waves
Authors: Clauß Felix , Epple Niklas , Ahrens Mark Alexander , Niederleithinger Ernst , Mark Peter
Published: January 2022

The integral collection of information such as strains, cracks, or temperatures by ultrasound offers the best prerequisites to monitor structures during their lifetime. In this paper, a novel approach is proposed which uses the collected information in the coda of ultrasonic signals to infer the condition of a structure. This approach is derived from component tests on a reinforced concrete beam subjected to four-point bending in the lab at Ruhr University Bochum. In addition to ultrasonic measurements, strain of the reinforcement is measured with fiber optic sensors. Approached by the methods of moment-curvature relations, the steel strains serve as a reference for velocity changes of the coda waves. In particular, a correlation between the relative velocity change and the average steel strain in the reinforcement is derived that covers 90% of the total bearing capacity. The purely empirical model yields a linear function with a high level of accuracy (R2=0.99, RMSE≈90μstrain).
Effect of Temperature Ageing on Injection Molded High-Density Polyethylene Parts Modified by Accelerated Electrons
Authors: Mizera Ales , Manas Miroslav , Stoklasek Pavel
Published: January 2022

The temperature ageing of high-density polyethylene (HDPE) modified by accelerated electrons was studied. Commodity plastic HDPE was used as a basic polymer material which was modified by radiation cross-linking. This polymer was used because of its excellent processability and chemical resistance. Plastic injection molding technology was used for the production of test specimens. These specimens were modified with the dose of radiation 33, 66, 99, 132, 165, and 198 kGy. The prepared specimens were tested to determine: gel content, degree of swelling, temperature stability, and changes in mechanical properties after temperature ageing. The results were determined by scanning electron microscopy (SEM) analysis on the fracture surfaces. The results of this study confirm that modification of HDPE by radiation cross-linking has a significant effect on increasing temperature stability. It has been shown that HDPE modified by radiation cross-linking can withstand temperatures exceeding the melting point of the original HDPE for a short-term.
Influence of Basalt Fibers on the Crack Resistance of Asphalt Mixtures and Mechanism Analysis
Authors: Wu Bangwei , Meng Weijie , Xia Ji , Xiao Peng
Published: January 2022

The paper aims to investigate the influence of basalt fiber (BF) on the crack resistance of the asphalt mixture and conduct a mechanical analysis. First, two typical asphalt mixtures, namely AC-13 and SMA-13, were designed. The impact of BF on the mixture design results was analyzed. Then, several macroscopic tests, namely the four-point bending test, indirect tensile test, and semicircular bending test (SCB), were conducted to assess the effect of BF on the cracking resistance of asphalt mixtures. Finally, the influence of BF on the cracking resistance of asphalt mixtures was analyzed based on an environmental scanning electron microscope (ESEM) observation. The results show that: (1) BF increases the optimal asphalt content of AC13 and decreases the optimal asphalt content of SMA-13, which is caused by the different asphalt-absorption capacity of BF and lignin fiber (LF). (2) BF enhances both the fatigue crack resistance and temperature crack resistance of asphalt mixtures. The enhancement on the SMA-13 is more significant, indicating that the enhancement of BF on asphalt mixtures is related to the type of aggregate gradation. (3) BFs in the asphalt mixture lap each other to form a spatial network structure. Such structure can effectively improve the crack resistance of the mixture by dispersing the load stress and preventing the flow of asphalt mastic. The study results provide an effective method to design crack-resistant asphalt mixtures.
Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome
Authors: Özkan Uğur , Gürdoğan Muhammet , Öztürk Cihan , Demir Melik , Akkuş Ömer Feridun , Yılmaz Efe , Altay Servet
Published: January 2022

Background and Objectives: Excessive coronary thrombus burden is known to cause an increase in mortality and major adverse cardiac events (MACEs) in NSTE-ACS (non-ST acute coronary syndrome) patients. We investigated the association between the systemic immune-inflammation index (SII) and coronary thrombus burden in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent coronary angiography and percutaneous coronary intervention (PCI). Materials and Methods: A total of 389 patients with the diagnosis of NSTEMI participated in our study. Coronary thrombus burden was classified in the TIMI (thrombolysis in myocardial infarction) thrombus grade scale and patients were divided into two groups: a TIMI thrombus grade 0–1 group (n = 209, 157 males) and a TIMI thrombus grade 2–6 group (n = 180, 118 males). Demographics, angiographic lesion images, coronary thrombus burden, clinical risk factors, laboratory parameters, and SII score were compared between the two groups. Results: The high thrombus burden patient group had a higher neutrophil count, WBC count, platelet count, and systemic immune-inflammation index (SII) (p < 0.001). The receiver operating characteristic (ROC) curve analysis showed that at a cutoff of 1103, the value of SII manifested 74.4% sensitivity and 74.6% specificity for detecting a high coronary thrombus burden. Conclusions: Our study showed that the SII levels at hospital admission were independently associated with high coronary thrombus with NSTEMI.
Factors Influencing the Concentration of Exhaled Nitric Oxide (FeNO) in School Children Aged 8–9-Years-Old in Krakow, with High FeNO Values ≥ 20 ppb
Authors: Czubaj-Kowal Marta , Nowicki Grzegorz Józef , Kurzawa Ryszard , Polak Maciej , Ślusarska Barbara
Published: January 2022

Background and Objectives: Measurement of fractional exhaled nitric oxide (FeNO) concentration is currently used as a non-invasive biomarker to assess airway inflammation. Many factors can influence the FeNO level. However, there have been no reports concerning factors attributed to FeNO levels in different age groups of children, especially those with high FeNO values. Therefore, this study aimed to assess the influence of selected factors on nitric oxide concentration in exhaled air in children aged 8–9 attending class 3 of public primary schools in Krakow with high FeNO values ≥ 20 ppb. Materials and Methods: The population-based study covered all third-grade pupils attending primary schools in the city of Krakow. Five thousand, four hundred and sixty children participated in the first screening stage, conducted from October 2017 to January 2018. Then, 792 participants with an FeNO level ≥ 20 ppb were selected. Finally, those selected pupils were invited to participate in the second stage, diagnostic, in April 2018. Four hundred and fifty-four children completed the diagnostic stage of the study, and their data was included in the presented analysis. Results and Conclusions: Significantly higher FeNO levels were observed in children diagnosed with the following diseases: asthma, allergic rhinitis, atopic dermatitis, and allergy (p < 0.05). In addition, it was observed that a higher FeNO concentration characterised children taking antihistamines compared to children not taking those medications (p = 0.008). In multivariate models, we observed that regardless of sex, age, BMI value, home smoking, and whether they were taking medications, children who had allergic rhinitis, or atopic dermatitis, or allergies had significantly higher FeNO levels. The strongest relationship was noted with allergic diseases. The results of our study may be of importance to clinicians when interpreting FeNO results, for example, when making a therapeutic decision.
Effect of Impregnated Phenolic Resins on the Cellulose Membrane for Polymeric Insulator
Authors: Syed Hashim Sharifah Nurul Ain , Zakaria Sarani , Chia Chin Hua , Zainuddin Zalita , Rosenau Thomas , Syed Jaafar Sharifah Nabihah
Published: January 2022

In this study, a cellulose membrane (CM) was chemically treated with phenolic (PF) resin to improve its performance as a polymeric insulator. The CM was prepared from kenaf pulp, and the PF was synthesized from oil palm empty fruit (EFB) fibre. Four different concentrations of synthesized PF resin (5, 10, 15, and 20 wt.%) were impregnated under wet or dry conditions. Thermal analysis of the phenolic cellulose membrane (PCM) showed that the samples had good chemical interaction and compatibility. The PF uptake in the wet phenolic cellulose membrane (PCMW) was higher than in the dry phenolic cellulose membrane (PCMD). During the PF uptake, the CM underwent solvent exchange and absorption in wet and dry membranes, respectively. This difference also affected the crosslinking of PCM samples via the formation of methylene bridges. Due to the PF treatment, the PCM showed lower water absorption than CM. The PF concentrations also affect the surface roughness and electrical properties of PCM samples. These findings prove that PCM can be used as a renewable and green polymer electrical insulator.
NMR Detection and Structural Modeling of the Ethylene Receptor LeETR2 from Tomato
Authors: Wei Shukun , Yang Yaqing , Yuan Yuan , Du Lingyu , Xue Hongjuan , OuYang Bo
Published: January 2022

The gaseous plant hormone ethylene influences many physiological processes in plant growth and development. Plant ethylene responses are mediated by a family of ethylene receptors, in which the N-terminal transmembrane domains are responsible for ethylene binding and membrane localization. Until now, little structural information was available on the molecular mechanism of ethylene responses by the transmembrane binding domain of ethylene receptors. Here, we screened different constructs, fusion tags, detergents, and purification methods of the transmembrane sensor domain of ethylene receptors. However, due to their highly hydrophobic transmembrane domain (TMD), only a KSI-fused LeETR21–131 from tomato yielded a good-quality nuclear magnetic resonance (NMR) spectrum in the organic solvent. Interestingly, a dimer model of LeETR21–131 built by the AlphaFold2 algorithm showed greatly converged structures. The interaction analysis of ethylene and LeETR21–131 using molecular docking and molecular dynamics (MD) simulations demonstrated the potential binding sites of ethylene in LeETR21–131. Our exploration provides valuable knowledge for further understanding of the ethylene-perception process in ethylene receptors.
The Effect of Direct Strip Casting on the Kinetics of Phase Transformation of a Dual Phase Steel
Authors: Mai Nam , Schulz Christiane , Stanford Nikki
Published: January 2022

A dual phase steel has been produced directly from the liquid under conditions that simulate direct strip casting and thin slab casting. The kinetics of polygonal ferrite formation during the inter-critical anneal were quantified using the JMAK approach, and this revealed significantly retarded transformation kinetics in the strip cast samples compared to the commercial steel that was processed through the conventional hot rolling approach. The transformation rate in the strip cast samples were as much as three orders of magnitude slower compared to the commercial steel. It was found that the kinetics of the ferrite formation were retarded principally by the large prior austenite grain size in the strip cast samples, and this hypothesis was tested experimentally by both coarsening of the prior austenite grain size, and by refinement of the prior austenite grain size. However, even after grain size normalization, small differences in transformation kinetics between the direct strip cast and commercial steel specimens were observed. These differences were explained by investigation of MnS precipitation in the steels. It was found that the transformation rate is high when the solutes are in solid solution, and that the rate of transformation slows significantly when precipitation of nano-precipitates occurs.
Establishment of a Rapid Typing Method for Coronavirus Disease 2019 Mutant Strains Based on PARMS Technology
Authors: Gao Lei , Zu Xiangyang , Liu Xiaohui , Yu Zhangqing , Du Zhe , Hu Zhigang , Xue Yun
Published: January 2022

Purpose: This study aims to establish a competitive allele-specific PCR based on penta-primer amplification refractory mutation system (PARMS) technology to detect the key mutation sites of variant of concern (VOC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus for rapid typing. Methods: Competitive allele-specific primers and universal primers were designed for the key gene mutation sites N501Y, E484K, L452R, and K417N of SARS-CoV-2 VOCs, respectively.Using the principle of allele-specific polymerase chain reaction and fluorescence energy resonance transfer, different VOCs can be differentiated. Results: Using reverse transcribed cDNA of different VOCs as specimens, through double-blind detection, different VOC types can be effectively identified, with an accuracy rate of 100%. Through the identification and detection of different VOCs, effective differentiation can be achieved. Conclusions: The system has high specificity and sensitivity, with a detection limit of 1.28 copies/reaction.PARMS technology is fast, efficient, and low-cost. It is used for the identification and detection of the popular SARS-CoV-2 VOCs, which is helpful for the rapid and accurate prevention and control of COVID-19 epidemic.
Effects of Foliar Application of ZnO Nanoparticles on Lentil Production, Stress Level and Nutritional Seed Quality under Field Conditions
Authors: Kolenčík Marek , Ernst Dávid , Komár Matej , Urík Martin , Šebesta Martin , Ďurišová Ľuba , Bujdoš Marek , Černý Ivan , Chlpík Juraj , Juriga Martin , Illa Ramakanth , Qian Yu , Feng Huan , Kratošová Gabriela , Barabaszová Karla Čech , Ducsay Ladislav , Aydın Elena
Published: January 2022

Nanotechnology offers new opportunities for the development of novel materials and strategies that improve technology and industry. This applies especially to agriculture, and our previous field studies have indicated that zinc oxide nanoparticles provide promising nano-fertilizer dispersion in sustainable agriculture. However, little is known about the precise ZnO-NP effects on legumes. Herein, 1 mg·L−1 ZnO-NP spray was dispersed on lentil plants to establish the direct NP effects on lentil production, seed nutritional quality, and stress response under field conditions. Although ZnO-NP exposure positively affected yield, thousand-seed weight and the number of pods per plant, there was no statistically significant difference in nutrient and anti-nutrient content in treated and untreated plant seeds. In contrast, the lentil water stress level was affected, and the stress response resulted in statistically significant changes in stomatal conductance, crop water stress index, and plant temperature. Foliar application of low ZnO-NP concentrations therefore proved promising in increasing crop production under field conditions, and this confirms ZnO-NP use as a viable strategy for sustainable agriculture.
A Structural View of miRNA Biogenesis and Function
Authors: Leitão Ana Lúcia , Enguita Francisco J.
Published: January 2022

Micro-RNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of gene expression. Since their discovery in 1993, they have been the subject of deep study due to their involvement in many important biological processes. Compared with other ncRNAs, miRNAs are generated from devoted transcriptional units which are processed by a specific set of endonucleases. The contribution of structural biology methods for understanding miRNA biogenesis and function has been essential for the dissection of their roles in cell biology and human disease. In this review, we summarize the application of structural biology for the characterization of the molecular players involved in miRNA biogenesis (processors and effectors), starting from the X-ray crystallography methods to the more recent cryo-electron microscopy protocols.