bluuebunny/crossref_metadata_2025 huggingface dataset:
Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism
Authors: Landen Shanie , Jacques Macsue , Hiam Danielle , Alvarez-Romero Javier , Harvey Nicholas R. , Haupt Larisa M. , Griffiths Lyn R. , Ashton Kevin J. , Lamon Séverine , Voisin Sarah , Eynon Nir
Published: November 2021

Nearly all human complex traits and diseases exhibit some degree of sex differences, with epigenetics being one of the main contributing factors. Various tissues display sex differences in DNA methylation; however, this has not yet been explored in skeletal muscle, despite skeletal muscle being among the tissues with the most transcriptomic sex differences. For the first time, we investigated the effect of sex on autosomal DNA methylation in human skeletal muscle across three independent cohorts (Gene SMART, FUSION, and GSE38291) using a meta-analysis approach, totalling 369 human muscle samples (222 males and 147 females), and integrated this with known sex-biased transcriptomics. We found 10,240 differentially methylated regions (DMRs) at FDR < 0.005, 94% of which were hypomethylated in males, and gene set enrichment analysis revealed that differentially methylated genes were involved in muscle contraction and substrate metabolism. We then investigated biological factors underlying DNA methylation sex differences and found that circulating hormones were not associated with differential methylation at sex-biased DNA methylation loci; however, these sex-specific loci were enriched for binding sites of hormone-related transcription factors (with top TFs including androgen (AR), estrogen (ESR1), and glucocorticoid (NR3C1) receptors). Fibre type proportions were associated with differential methylation across the genome, as well as across 16% of sex-biased DNA methylation loci (FDR < 0.005). Integration of DNA methylomic results with transcriptomic data from the GTEx database and the FUSION cohort revealed 326 autosomal genes that display sex differences at both the epigenome and transcriptome levels. Importantly, transcriptional sex-biased genes were overrepresented among epigenetic sex-biased genes (pvalue = 4.6e−13), suggesting differential DNA methylation and gene expression between male and female muscle are functionally linked. Finally, we validated expression of three genes with large effect sizes (FOXO3A,ALDH1A1, andGGT7) in the Gene SMART cohort with qPCR.GGT7, involved in antioxidant metabolism, displays male-biased expression as well as lower methylation in males across the three cohorts. In conclusion, we uncovered 8420 genes that exhibit DNA methylation differences between males and females in human skeletal muscle that may modulate mechanisms controlling muscle metabolism and health.
Challenges of reverse migration in India: a comparative study of internal and international migrant workers in the post-COVID economy
Authors: Khan Asma , Arokkiaraj H.
Published: November 2021

In India, the major drivers of both internal and international migration are the prevailing unemployment, competitive labour market and enhanced livelihood prospects in the destination state or country. However, the nationwide lockdown and the sealing of inter-state and international borders to control the COVID-19 pandemic triggered the reverse migration of informal migrant workers. This requires the central and state governments to collectively forge strategies to enable their reverse migration and smooth reintegration in the post-COVID economy. In this paper, we have focused on the inter-state migrants in India and returnee migrants only from Gulf countries as they account for two-thirds of Indian migrants living abroad. This study conducted a comparative analysis of the Indian government’s varied approach towards its internal and international migrants during their reverse migration, repatriation and reintegration after the announcement of the lockdown. Firstly, the paper compares the challenges faced by internal and international migrant workers during these stages with the help of in-depth interview data collected from migrants and social workers. Secondly, the varied governmental responses towards their repatriation are discussed. Thirdly, it analyses the obstacles in their economic reintegration to help frame suitable welfare policies for the Indian migrant community.
Intact survival from severe cardiogenic shock caused by the first attack of atrial tachycardia treated with extracorporeal membrane oxygenation and surgical left atrium appendage resection: a case report
Authors: Shimizu Tatsuhiko , Kanazawa Tomoyuki , Sakura Takanobu , Shimizu Kazuyoshi , Iwasaki Tatsuo
Published: November 2021

Background

Atrial tachycardia (AT) is rare in children and can usually be reversed to sinus rhythm with pharmacotherapy and cardioversion. We report a rare case of severe left-sided heart failure due to refractory AT.

Case presentation

A 12-year-old boy had AT with a heart rate of 180 beats/minute, which was refractory to any medication and defibrillation despite the first attack. Due to rapid cardiorespiratory collapse shortly after arriving at our hospital, central extracorporeal membrane oxygenation (ECMO) with left arterial venting was started immediately. Although AT persisted after that, it stopped on the 3rd day after admission following surgical resection of the left atrial appendage thought to be the source of AT. He was weaned off ECMO on the 7th day and ventilator on the 14th day.

Conclusions

The appropriate timing of central ECMO and surgical ablation were effective in saving this child from a life-threatening situation caused by refractory AT.
The PyPIF5-PymiR156a-PySPL9-PyMYB114/MYB10 module regulates light-induced anthocyanin biosynthesis in red pear
Authors: Liu Hainan , Shu Qun , Lin-Wang Kui , Allan Andrew C. , Espley Richard V. , Su Jun , Pei Maosong , Wu Jun
Published: November 2021

Some cultivars of pear (Pyrus L.) show attractive red fruit skin due to anthocyanin accumulation. This pigmentation can be affected by environmental conditions, especially light. To explore the light-induced regulation network for anthocyanin biosynthesis and fruit coloration in pear, small RNA libraries and mRNA libraries from fruit skins of ‘Yunhongyihao’ pear were constructed to compare the difference between bagging and debagging treatments. Analysis of RNA-seq of fruit skins with limited light (bagged) and exposed to light (debagged), showed that PyPIF5 was down-regulated after bag removal. PymiR156a was also differentially expressed between bagged and debagged fruit skins. We found that PyPIF5 negatively regulated PymiR156a expression in bagged fruits by directly binding to the G-box motif in its promoter. In addition, PymiR156a overexpression promoted anthocyanin accumulation in both pear skin and apple calli. We confirmed that PymiR156a mediated the cleavage of PySPL9, and that the target PySPL9 protein could form heterodimers with two key anthocyanin regulators (PyMYB114/PyMYB10). We proposed a new module of PyPIF5-PymiR156a-PySPL9-PyMYB114/MYB10. When the bagged fruits were re-exposed to light, PyPIF5 was down-regulated and its inhibitory effect on PymiR156a was weakened, which leads to degradation of the target PySPL, thus eliminating the blocking effect of PySPL on the formation of the regulatory MYB complexes. Ultimately, this promotes anthocyanin biosynthesis in pear skin.
Proportion and predictors of remission and recovery in first-episode psychosis: Systematic review and meta-analysis
Authors: Catalan Ana , Richter Anja , Salazar de Pablo Gonzalo , Vaquerizo-Serrano Julio , Mancebo Gonzalo , Pedruzo Borja , Aymerich Claudia , Solmi Marco , González-Torres Miguel Á. , Gil Patxi , McGuire Philip , Fusar-Poli Paolo
Published: November 2021

Background

To determine the proportion of patients in symptomatic remission and recovery following a first-episode of psychosis (FEP).

Methods

A multistep literature search using the Web of Science database, Cochrane Central Register of Reviews, Ovid/PsychINFO, and trial registries from database inception to November 5, 2020, was performed. Cohort studies and randomized control trials (RCT) investigating the proportion of remission and recovery following a FEP were included. Two independent researchers searched, following PRISMA and MOOSE guidelines and using a PROSPERO protocol. We performed meta-analyses regarding the proportion of remission/recovery (symptomatic plus functional outcomes). Heterogeneity was measured employing Q statistics and I2 test. To identify potential predictors, meta-regression analyses were conducted, as well as qualitative reporting of studies included in a systematic review. Sensitivity analyses were performed regarding different times of follow-up and type of studies.

Results

One hundred articles (82 cohorts and 18 RCTs) were included in the meta-analysis. The pooled proportion of symptomatic remission was 54% (95%CI [30, 49–58]) over a mean follow-up period of 43.57 months (SD = 51.82) in 76 studies. After excluding RCT from the sample, the proportion of remission remained similar (55%). The pooled proportion of recovery was 32% (95%CI [27–36]) over a mean follow-up period of 71.85 months (SD = 73.54) in 40 studies. After excluding RCT from the sample, the recovery proportion remained the same. No significant effect of any sociodemographic or clinical predictor was found.

Conclusions

Half of the patients are in symptomatic remission around 4 years after the FEP, while about a third show recovery after 5.5 years.
Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity
Authors: Stocks Ben , Zierath Juleen R
Published: November 2021

Diabetes is a global epidemic, of which type 2 diabetes makes up the majority of cases. Nonetheless, for some individuals, type 2 diabetes is eminently preventable and treatable via lifestyle interventions. Glucose uptake into skeletal muscle increases during and in recovery from exercise, with exercise effective at controlling glucose homeostasis in individuals with type 2 diabetes. Furthermore, acute and chronic exercise sensitizes skeletal muscle to insulin. A complex network of signals converge and interact to regulate glucose metabolism and insulin sensitivity in response to exercise. Numerous forms of post-translational modifications (eg, phosphorylation, ubiquitination, acetylation, ribosylation, and more) are regulated by exercise. Here we review the current state of the art of the role of post-translational modifications in transducing exercise-induced signals to modulate glucose uptake and insulin sensitivity within skeletal muscle. Furthermore, we consider emerging evidence for noncanonical signaling in the control of glucose homeostasis and the potential for regulation by exercise. While exercise is clearly an effective intervention to reduce glycemia and improve insulin sensitivity, the insulin- and exercise-sensitive signaling networks orchestrating this biology are not fully clarified. Elucidation of the complex proteome-wide interactions between post-translational modifications and the associated functional implications will identify mechanisms by which exercise regulates glucose homeostasis and insulin sensitivity. In doing so, this knowledge should illuminate novel therapeutic targets to enhance insulin sensitivity for the clinical management of type 2 diabetes.
The Less Selfish Gene
Authors: Nixon Rob
Published: November 2021

Why have millions of readers and viewers become magnetized by the hitherto arcane field of plant communication? The article argues that the contemporary appeal of plant communication is rooted in a quest for alternative modes of being to neoliberalism, modes more accommodating of the coexistence of cooperation and competition in human and more-than-human communities. This ascendant understanding of plant communication and forest dynamics offers a counternarrative of flourishing, a model of what George Monbiot has called, in another context, “private sufficiency and public wealth.”
Terror Capitalism
Authors: Byler Darren
Published: November 2021

In Terror Capitalism anthropologist Darren Byler theorizes the contemporary Chinese colonization of the Uyghur Muslim minority group in the northwest autonomous region of Xinjiang. He shows that the mass detention of over one million Uyghurs in “reeducation camps” is part of processes of resource extraction in Uyghur lands that have led to what he calls terror capitalism—a configuration of ethnoracialization, surveillance, and mass detention that in this case promotes settler colonialism. Drawing on ethnographic fieldwork in the regional capital Ürümchi, Byler shows how media infrastructures, the state’s enforcement of “Chinese” cultural values, and the influx of Han Chinese settlers contribute to Uyghur dispossession and their expulsion from the city. He particularly attends to the experiences of young Uyghur men—who are the primary target of state violence—and how they develop masculinities and homosocial friendships to protect themselves against gendered, ethnoracial, and economic violence. By tracing the political and economic stakes of Uyghur colonization, Byler demonstrates that state-directed capitalist dispossession is coconstructed with a colonial relation of domination.
α-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization
Authors: Barai Amlan , Mukherjee Abhishek , Das Alakesh , Saxena Neha , Sen Shamik
Published: November 2021

The mechanisms by which the mechanoresponsive actin crosslinking protein α-actinin-4 (ACTN4) regulates cell motility and invasiveness remain incompletely understood. Here, we show that, in addition to regulating protrusion dynamics and focal adhesion formation, ACTN4 transcriptionally regulates expression of non-muscle myosin IIB (NMM IIB; heavy chain encoded by MYH10), which is essential for mediating nuclear translocation during 3D invasion. We further show that an indirect association between ACTN4 and NMM IIA (heavy chain encoded by MYH9) mediated by a functional F-actin cytoskeleton is essential for retention of NMM IIA at the cell periphery and modulation of focal adhesion dynamics. A protrusion-dependent model of confined migration recapitulating experimental observations predicts a dependence of protrusion forces on the degree of confinement and on the ratio of nucleus to matrix stiffness. Together, our results suggest that ACTN4 is a master regulator of cancer invasion that regulates invasiveness by controlling NMM IIB expression and NMM IIA localization. This article has an associated First Person interview with the first author of the paper.
Hacı Bayram Başer. Sûfîler ve Sultanlar: Klasik Dönemde Tasavvuf-Siyaset İlişkileri
Authors: Orhan Abdullah Taha
Published: November 2021

Th review of the book.
Die sicherstellung der wettbewerbsfähigkeit des griechischen tourismus
Authors: Γκιούρας Γεώργιος
Published: November 2021

Εν μέσω μιας διαρκούς αυξανόμενης διεθνοποίησης στις τουριστικές αγορές όλο και περισσότεροι προορισμοί ανταγωνίζονται για να κερδίσουν την προτίμηση των τουριστών. Αυτόματα η ανταγωνιστικότητα αποκτά έναν όλο και πιο σημαντικό ρόλο. Η Ελλάδα βρίσκεται τουριστικά αντιμέτωπη όχι μόνο με τον αυξανόμενο ανταγωνισμό από ώριμους προορισμούς της Μεσογείου όπως η Ισπανία ή η Ιταλία αλλά και με σχετικά καινούριους προορισμούς όπως π.χ. η Κροατία. Η κατάσταση αυτή δείχνει οτι ένα ανταγωνιστικό ελληνικό προϊόν είναι πλέον επιτακτική ανάγκη.Για τον προσδιορισμό των παραγόντων από τους οποίους εξαρτάται η ανταγωνιστικότητα χρησιμοποιήθηκε το γνωστό και ώς διαμάντι της ανταγωνιστικότητας των Porter/Borner με την προσαρμογή που έκανε ο Bieger για την εφαρμογή του μοντέλου σε τουριστικούς προορισμούς. Λήφθηκαν υπ’όψιν επίσης οι τρείς βασικοί παράμετροι μιας αειφόρου ανάπτυξης (κοινωνία, περιβάλλον, οικονομία).Στο πλαίσιο μιας στρατηγικής ανάλυσης που αποτελείται από μια ανάλυση του προορισμού, μια ανάλυση της αγοράς και μια ανάλυση των εξωγενών παραγόντων έγινε κατ`αρχήν μια αξιολόγηση της σημερινής κατάστασης του ελληνικού τουρισμού. Η αντιπαράθεση αυτων των στοιχείων με το επίπεδο τουριστικής προσφοράς των χωρών της Ισπανίας, Ιταλίας και Τουρκίας οι οποίες και αξιολογήθηκαν ώς βασικοί ανταγωνιστές ανέδειξε τα δυνατά και αδύνατα σημεία του ελληνικού τουρισμού. Κατά την ανάλυση λοιπόν αυτή το κέντρο βάρος του ελληνικού τουρισμού εντοπίζεται στη συναρμογή του από αυθεντικά και γεμάτα αντιθέσεις δεδομένα της ελληνικής φύσεως καθώς και την πλούσια αρχαιολογική και πολιτιστική κληρονομιά. Αυτά αποτελούν τα δυνατά σημεία του ελληνικού τουρισμού. Τα κυριότερα αδύνατα σημεία εντοπίζονται σε προβλήματα ποιότητας όσον αφορά τις γενικές και ειδικές υποδομές, σε μια προσφορά καταλυμάτων που κυριαρχείται από μικρά ξενοδοχεία και είναι σε μεγάλο βαθμό εποχιακή και τέλος στην οργανωτική δομή σε εθνικό, περιφερειακό και τοπικό επίπεδο των φορέων προώθησης του τουρισμού. Οι ευκαιρίες όσον αφορά τη μελλοντική εξέλιξη του τουρισμού στην Ελλάδα εντοπίζονται κυρίως στη δημιουργία τουριστικών προφίλ τα οποία δίπλα στο κεντρικό τουριστικό προϊόν της Ελλάδας δηλαδή «Θάλασσα, ήλιος, παραλίες» θα το εμπλουτίσουν και θα το εμβαθύνουν. Στο πλαίσιο των συμπερασμάτων αυτής της εργασίας έγιναν με βάση τη συνάφεια των λειτουργιών μιας ολοκληρωμένης τουριστικής πολιτικής προτάσεις που αφορούν και το μάρκετινγκ αλλά και την οργάνωση του ελληνικού τουρισμού. Αυτες απευθύνονται κατά κύριο λόγο στους διάφορους φορείς τουρισμού σε εθνικό περιφερειακό και τοπικό επίπεδο. Η επιστημονική ανασκόπηση στο τέλος αυτής της εργασίας έδειξε οτι το μοντέλο των Porter/Borner προκειμένου να εφαρμοστεί σε προβλήματα ανταγωνιστικότητας τουριστικών προορισμών πρέπει να διαφοροποιηθεί. Στον παράγοντα συνθήκες ζήτησης πρέπει κατά συνέπεια να συμπεριληφθεί όχι μόνο η εκάστοτε κατάσταση της ζήτησης αλλά και οι παράγοντες που θα επιφέρουν μελλοντικές αλλαγές στην ζήτηση τουριστικών υπηρεσιών. Έτσι το μοντέλο αποκτά μια περισσότερο δυναμική παρά στατική διάσταση.
Έννομες συνέπειες δικαστικών αποφάσεων στο αστικό και διοικητικό δικονομικό δίκαιο
Authors: Σασσάνης Αθανάσιος
Published: November 2021

Η υπό καταχώρηση διδακτορική διατριβή αναφέρεται στις έννομες συνέπειες των δικαστικών αποφάσεων στο αστικό δικονομικό δίκαιο και στο διοικητικό δικονομικό δίκαιο. Πρόκειται για συγκριτική μελέτη ανάμεσα στους δύο δικονομικούς κλάδους. Πιο συγκεκριμένα, το έργο αναφέρεται στο δεδικασμένο, τη διαπλαστική ενέργεια και την εκτελεστότητα. Στο δεδικασμένο και τη διαπλαστική ενέργεια δίνεται και η μεγαλύτερη βαρύτητα. Η έρευνα εμβαθύνει κυρίως ως προς τις διαφοροποιήσεις, οι οποίες εντοπίζονται κυρίως στη θεματική της διαπλαστικής ενέργειας, αναζητώντας συγχρόνως τις αιτίες τους. Παρουσιάζονται επίσης αναλυτικά και οι σημαντικότερες ομοιότητες ανάμεσα στην πολιτική και την διοικητική δικονομία.Από πλευράς δεδικασμένου, εξετάζεται, η έννοια, η λειτουργία του δεδικασμένου και κατά κύριο λόγο τα όριά αυτού, σύμφωνα με το νομοθετικό πλαίσιο των δύο δικονομιών. Όσον αφορά στην διαπλαστική ενέργεια, εξετάζονται οι συνηθέστερες περιπτώσεις και πτυχές διάπλασης εννόμων σχέσεων και καταστάσεων του ιδιωτικού δικαίου, όπου και όταν απαιτείται η μεσολάβηση δικαστικής απόφασης για την επέλευσή της (της διάπλασης). Από το χώρο της διοικητικής δικονομίας, εξετάζονται μείζονα ζητήματα ως προς το περιεχόμενο των διαπλαστικών αποφάσεων, την αναδρομική ισχύ του διατακτικού τους και τον απόλυτο ή μη χαρακτήρα τους.Στο έργο επισημαίνονται πρώτα οι έννομες συνέπειες των αποφάσεων κατά το αστικό δικονομικό δίκαιο. Κατόπιν, η έρευνα επικεντρώνεται στα αντίστοιχα ζητήματα στο πλαίσιο της διοικητικής δικονομίας, ενώ στο τέλος, επιχειρείται η συναγωγή συμπερασμάτων.
Regulation, competition and firm productivity and performance in network industries
Authors: Ασημακόπουλος Γρηγόριος
Published: November 2021

Η παρούσα διατριβή καθοδηγείται από δύο βασικούς στόχους. Ο πρώτος είναι να καταλάβουμε πώς τα ρυθμιστικά μέτρα που έλαβαν οι κυβερνήσεις επηρέασαν τον ανταγωνισμό στις βιομηχανίες δικτύου. Ειδικότερα, δίνεται ιδιαίτερη προσοχή στις διαφορές στην ρύθμιση του κόστους αλλαγής που εφαρμόζεται από διαφορετικές κυβερνήσεις στην Ευρωπαϊκή Ένωση. Ο δεύτερος στόχος είναι η καλύτερη κατανόηση του τρόπου με τον οποίο η πελατειακή βάση επηρεάζει το ανταγωνιστικό πλεονέκτημα των εταιρειών σε βιομηχανίες δικτύου και ως εκ τούτου, η ικανότητα να βελτιώσει την παραγωγικότητα και τα οικονομικά της επιχείρησης. Ο στόχος είναι να μελετηθεί ο τρόπος με τον οποίο παράγοντες εξωτερικοί της εταιρείας, κανονιστικά και τεχνολογικά θέματα, επηρεάζουν τον ανταγωνιστικό πλεονεκτήματα τόσο των ηγετών στην αγορά όσο και των υπολοίπων ανταγωνιστών σε μια βιομηχανία δικτύου.
Patient reported outcome measures in childbirth and postpartum maternal quality of life: a protocol for systematic review of measurement properties.
Authors: O'Byrne Laura J. , Maher Gillian , Khashan Ali S. , Greene Richard , Browne John , McCarthy Fergus P.
Published: November 2021

Background: Patient centred healthcare is the corner stone to many healthcare strategies. Patient specific health needs should be at the fore of healthcare improvements and quality measurements.  Patient reported outcome measures (PROM) that support real world clinical effectiveness assessments are increasingly being used to highlight domains where there is the greatest scope for change.

Objectives: This systematic review aims to identify and evaluate existing patient reported assessment measures/tool(s) that can be used in developing a PROM for postpartum women. We will assess and evaluate their measurement properties in a transparent and structured way in accordance with the COSMIN guidelines.

Methods: Methodological guidelines for systematic reviews of PROMs have been developed by the COSMIN initiative and will be followed for this systematic review. A systematic literature review will be performed using PubMed and EMBASE from inception to the present day. Two reviewers independently will judge eligibility, conduct data extraction and assess the methodological quality of each study as per COSMIN guidelines. Inclusion criteria: studies should concern PROM with an aim to evaluate measurement properties in the development or the evaluation of a PROM of interest. Included PROMS will focus upon postpartum women assessing morbidity and quality of care. All peer reviewed studies with an assessment tool designed for patient completion will be considered. Exclusion criteria; abstract, letters and non-peer reviewed publications. Studies will be graded on measurement properties and quality of evidence as laid out by COSMIN. All studies and characteristics eligible for inclusion will be summarised and a recommendation to the most suitable measurement tool(s) will be given.

Discussion: We will provide a comprehensive description of all available patient reported assessment tools available for childbirth and postpartum quality of life and recommend based on COSMIN guidelines the most suitable instrument(s) available for use.
The genome sequence of the devil’s coach horse, Ocypus olens (Müller, 1764)
Authors: Crowley Liam ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: November 2021

We present a genome assembly from an individual female Ocypus olens (the devil’s coach horse; Arthropoda; Insecta; Coleoptera; Staphylinidae). The genome sequence is 1,084 megabases in span. The majority (98.81%) of the assembly is scaffolded into 20 chromosomal pseudomolecules, with the X sex chromosome assembled.
Dynamic Processes in Professional and Business Etiquette
Authors: Ksenzenko O. , Robustova V.
Published: November 2021

The research focuses on the study of the dynamics of etiquette norms in the innovative communicative space. The paper considers the factors which may condition changes in etiquette norms and stimulate formation of new norms and rules. The contribution explains the importance of taking into account theoretical foundations of etiquette studies while considering innovative norms, and lays special emphasis on comparison of traditional and innovative norms. The article reveals the role of socio-cultural context in the process of implementation of etiquette norms, and outlines the factors which determine the variability of their functioning. The study highlights specific features of innovative etiquette norms: the focus of attention is on etiquette norms regulating behaviour in the online communicative environment – with special reference to business interaction, in particular, business interaction in the format of zoom conferences. The paper suggests classification of innovation norms, outlines etiquette gaps and ways of their elimination. The publication also explains the importance of practical valiability of the study, and accounts for the need in optimization of business etiquette training – with special reference to up-to-date conditions of professional interaction.
Construir la ciudadanía colectivamente: prácticas urbanas de una asamblea popular en Buenos Aires, Argentina.
Authors: Valeria Torres Fernanda
Published: November 2021

Traditional ideas about citizenship in their liberal conception emphasize the role played by the individual as the holder of rights and duties. These ideas have been strongly questioned by various currents of thought and from some fields of studies, such as urban studies. In this paper we seek to contribute to these debates by analyzing the urban practices of a popular assembly in the Autonomous City of Buenos Aires (CABA-Argentina). These practices are enmeshed in disputes between the old and the new, the public and the private, and the visible and invisible, configuring citizenships that promote ways of understanding and building more participatory and democratic cities. We analyze the activities of “making visible” and activism in relation to the homelessness problem as well as the Assembly’s intention of building an urban habitat anchored in the decommodification of the city and in collective projects. We conclude that this case testifies to the construction of citizen experiences that have great potential to displace the individualistic corset with which citizens’ rights are usually defined and defended.
Las clases medias y los desafíos de la participación: procesos de ciudadanización en la producción de ciudad (La Plata, Argentina. 2013-2015).
Authors: Ventura Violeta
Published: November 2021

The question about the relationship between associative forms of participation and city production is the guideline of Latin American urban studies, widely studied in its intersection with popular sectors. This article seeks to link to that discussion, providing a case where the population involved belongs to the middle classes. To do this, we will analyze the process by which middle class youth collectively organized (2013-2015) in the city of La Plata (Argentina), to access urban land and, with it, a housing policy (PROCREAR). We will investigate how they built their claim on a public problem, moved within statehood and became co-producers of urban regulations (Ordinance 11094/13). Our main finding will be that the effectiveness of their practices rested, on the one hand, on factors specific to the group —broad and hierarchical networks of social relationships; collectivization of cultural capital; habituality within statehood— on the other, in the selectivity of state bureaucracies. Based on this, we will conclude that during the collective action of the middle classes in order to get involved in the production of the city, there was an active process of citizenship. The research starts from a qualitative methodological approach, using virtual ethnography, field observation and in-depth interviews as the main procedures.
Fair Resource Allocation in a Volatile Marketplace
Authors: Bateni MohammadHossein , Chen Yiwei , Ciocan Dragos Florin , Mirrokni Vahab
Published: November 2021

In settings where a platform must allocate finite supplies of goods to buyers, balancing overall platform revenues with the fairness of the individual allocations to platform participants is paramount to the well-functioning of the platform. This is made even more difficult by the fact that the supply of goods is in practice stochastic and difficult to forecast, such as in the case of online ad allocation, where the platform manages a supply of impressions that varies over time. In this paper, we design a fair allocation scheme that works in the presence of supply uncertainty. Algorithmically, the scheme repeatedly solves for Fisher market equilibria in a model predictive control fashion and is proved to admit constant factor guarantees versus the offline optimal. In addition, the scheme is tested on a sequence of real ad datasets, showing strong empirical performance.
Caring for an Aging Population in a Post-Pandemic World: Emerging Trends in the U.S. Older Adult Care Industry
Authors: Kong Lu , Hu Kejia , Walsman Matthew
Published: November 2021

This paper examines older adult care services during the outbreak of the COVID-19 global pandemic. Specifically, it investigates emerging developments initiated or augmented by the pandemic and discusses their permanency in a postpandemic world. Primary survey data are collected from both older adult care-providing organizations (supply) and individuals receiving or considering care (demand) in the United States. Qualitative support from various sources supplements the surveys. The results indicate a movement toward deinstitutional care options, which began prepandemic but intensified during the outbreak. Care organizations confirm this development, reporting more occupancy-related concerns. Findings also suggest that telehealth and digital communication tools have substantially expanded. Benefits, issues, and future projections of these trends are discussed, and some suggestions for industry reform are proposed. These results illuminate many actionable ideas for various stakeholders, including older adults, industry practitioners, and policymakers.
Autoimmune Thrombocytopenia in SLE and COVID-19
Authors: Suryo Pratama Yeremia , Pradiptakirana Riska , Rachmah Azkia , Prabowo Nurhasan Agung
Published: November 2021

Thrombocytopenia and hypercoagulopathy are haematological abnormalities commonly seen in individuals with coronavirus disease 2019 (COVID-19) and systemic lupus erythematosus (SLE). The difficulty arises when the patient has both diseases concurrently. The clinician should be able to comprehend the pathophysiology of these patient abnormalities in order to provide the best treatment possible. We present a case of a 20-year-old female COVID-19 patient with a history of SLE who had thrombocytopenia but normal D-dimer results. Our analysis revealed that the thrombocytopenia may have been caused by a relapse of lupus, not by COVID-19 infection. In this case, glucocorticoids were the primary therapy and produced excellent results.
Birth after previous caesarean section
Authors: Madeley Anna-Marie
Published: November 2021

Midwifery and obstetric involvement in supported decision making and subsequent clinical practice around birth after caesarean section has been much debated and negotiated for some time. This article discusses some of the clinical evidence and factors to be taken into account when providing support and information for women and birthing people considering their options for birth after caesarean. The article focuses on the currently published guidelines to support practice and guide discussions with women and birthing people. In the article, the terms ‘planned vaginal birth’ and ‘vaginal birth after caesarean’ are used interchangeably.
Learning in lockdown: exploring the impact of COVID-19 on interprofessional education
Authors: Power Alison , Palapal Sy Michael , Hutchings Maggie , Coleman Tracy , El-Awaisi Alla , Kitema Gatera Fiston , Gallagher Jean , Herath Chulani , McLarnon Nichola , Nagraj Shobhana , O'Carroll Veronica , Owens Melissa , Park Vikki , Pope Emma , Wetzlmair Lisa-Christin , Greaves P Jane , Anderson Elizabeth S
Published: November 2021

The COVID-19 pandemic has had a significant impact on the learning experiences of students undertaking health and social care programmes across the globe. In the UK, the Nursing and Midwifery Council introduced emergency standards for undergraduate programmes in 2020, making significant short-term changes to programme delivery. However, the mandate for all students to undertake interprofessional education remained. Interprofessional education is key to preparing students on health and social care programmes, as it enables students to work as effective members of multi-agency/multi-professional teams on qualification. It is an important element of training, as it has a direct impact on quality of care and service user experience.

This series of articles will explore the experiences of ‘lockdown learning’ from the perspective of academics, students and service users from a global perspective in relation to the delivery of interprofessional education during the pandemic, which necessitated a wholesale move from face-to-face, blended and online learning to include emergency remote teaching. The series was written by members of the Centre for the Advancement of Interprofessional Education Research Subgroup (Interprofessional Education Experiences) and aims to identify barriers and facilitators to successful shared learning and provide suggestions for how lessons learned can be taken forward to further enhance this important element of pre-registration education. The perceptions and attitudes of academics and students on such comprehensive changes are a unique and rich data source to explore and inform future provision.
SARS-CoV-2 infection complicated by intrahepatic cholestasis of pregnancy
Authors: Ahmed Irshad , Elgasim Mustafa , Rehal Anoop , Tan Bee K
Published: November 2021

This article reports a case of SARS-CoV-2 infection complicated by intrahepatic cholestasis of pregnancy in the second trimester in a South Asian woman. She presented with itchiness and grossly elevated bile acid following SARS-CoV-2 virus infection. Her cholestasis resolved in parallel with her infection while she was being treated with ursodeoxycholic acid. Bile acid is considered harmful to a developing fetus and is associated with adverse pregnancy outcomes, particularly stillbirth. Ursodeoxycholic acid is still commonly used in the treatment of these patients despite controversy about its value. It has anti-inflammatory properties and there have been suggestions that this could benefit patients with SARS-CoV-2. Elevated levels of primary bile acids (cholic and chenodeoxycholic acid) are considered harmful to a developing fetus, and are associated with adverse pregnancy outcomes, in particular, stillbirth. The secondary bile acid, ursodeoxycholic acid, is thought to be beneficial by reducing cholesterol production in the liver. This clinical case study highlights a diagnostic enigma in the management of this unique clinical case presentation.
Cooperation Between Learning Venues and its Limits: The Hotel Industry in Cancún (Mexico)
Authors: Vogelsang Beke , Röhrer Natascha , Fuchs Martina , Pilz Matthias
Published: November 2021

Purpose: Recently, high-quality vocational education and training has attracted much attention in Mexico. In this context, more practically applied skills are taught “on a dual basis”, combining classroom-based training with practical, on the job, training within the company. Dual practices are expected to modernize the skills formation system, and simultaneously support companies, while ensuring provision of skilled workers. For this reason, the vocational training system has been reformed in recent years. Hence, it is necessary that schools and universities, as well as companies, closely interact and coordinate their activities. It is also important that there is successful cooperation between vocational training organizations and companies, to contribute to the modernization of vocational training. The aim of this paper is to examine the cooperation between learning venues of vocational education in the hotel industry in Cancún (Quintana Roo, Mexico), one of the most important tourism destinations in Latin America. Research in vocational education and training, reveals a particular focus on the principles that are necessary for successful cooperation between learning venues. This study examines whether the setting of common goals, communication between companies and training organizations and governance are equally important.

Methods: In an exploratory approach, based on a qualitative framework, ten face-to-face expert interviews were conducted in Cancún. The interviews were then fully transcribed and evaluated using qualitative methods. The survey is complemented by further document analysis.

Findings: The results show that for successful cooperation between learning venues, the coordination of a common goal (to secure the availability of skilled workers) between different actors, and communication between companies and vocational training organizations, are particularly important for successful cooperation. Furthermore, it seems that companies are taking on a more dominant role, so that vocational training organizations must be more in line with the wishes of the hotels. The results indicate that partnership-based action is not very obvious. Accordingly, the aspect of governance plays a subordinate role.

Conclusion: The study shows that cooperation between learning venues in other regions and industries, requires certain principles to be successful. In this respect, the duration of the relationship as well as the specificity of a region or sector can influence the required principles. Therefore, the cooperation partners should agree on the principles in advance.
Una experiència de creació d’un espai virtual d’àrea de coneixement
Authors: Torrente Torné Margarita , Escobar Sola Xavier , Heredia Santaella Luis , Pino Roca Maria , Vicens Calderón Paloma , Colomina Fosch Maria Teresa
Published: November 2021

En la pràctica docent, una de les dificultats, que es fan evidents en el dia a dia, és la falta de relació dels continguts comuns i previs per part dels alumnes en una mateixa àrea de coneixement. Amb l’objectiu d’afavorir la relació dels continguts comuns dins l’àrea de coneixement es pretenia obrir un espaï virtual per a tots els alumnes que cursin assignatures de l’àrea on trobessin informació bàsica de les assignatures i que fos un lloc on intercanviar coneixements, recursos etc., de manera que acabés esdevenint una eina d’estudi i comprensió per als alumnes i que una eina més d’avaluació continuada per als professors.
Efectos de las estrategias de enseñanza y aprendizaje universitarias en el rendimiento académico
Authors: Moreno Blanca , Ramos Carmen , Salomé García Ana
Published: November 2021

Es de esperar que la implementación del Espacio Europeo de Educación Superior mejore el rendimiento académico de los estudiantes. Este trabajo analiza, mediante técnicas estadísticas multivariantes, la importancia de las características socio-demográficas, de actitud y esfuerzo del estudiante, así como la importancia de sus conocimientos previos y del sistema de aprendizaje como factores de los resultados académicos. Los resultados muestran que la evaluación continuada tiene un efecto indudable para superar la asignatura. La asistencia en clase, el esfuerzo realizado y la satisfacción con los estudios universitarios seleccionados y con la propia asignatura influyen de forma positiva sobre los resultados obtenidos por los estudiantes. El estudio también pone de manifiesto la necesidad de aumentar la interacción con los alumnos.
El profesional del Derecho en la formación del intérprete. Una experiencia didáctica
Authors: Sanz-Moreno Raquel
Published: November 2021

Este artículo presenta los resultados de una experiencia didáctica en el aula de interpretación en los servicios públicos que contó con la colaboración de dos expertos en Derecho Civil y Mercantil, por una parte, y Derecho de Extranjería por otra. Los alumnos del cuatro curso del Grado de Traducción y Mediación Interlingüística de francés de la Universitat de València participaron en varias sesiones de cuatro horas de interpretación de enlace con especialistas en la materia, que accedieron a colaborar en  ejercicios de simulación en los que se planteaban distintos casos prácticos. Los alumnos participaron activamente adoptando el papel de intérpretes o de usuarios del servicio, y posteriormente contestaron a cuestionarios sobre las sesiones y los aspectos sobre deontología profesional que se habían abordado. La evaluación de las citadas encuestas demuestra que la interacción con el profesional cambió radicalmente la perspectiva del alumnado respecto a su consideración de la interpretación judicial: los alumnos acabaron otorgando más importancia a los factores extratextuales (sobre todo culturales) de la situación comunicativa, perdieron el miedo a hacer el ridículo o a hablar en público, desarrollaron estrategias de colaboración con el profesional y lo integraron como un elemento fundamental en la interpretación entendida como un trabajo en equipo. La socialización con el experto se presenta, pues, como una herramienta a explorar en el aula de interpretación.
Los otros en una relación pedagógica para el cuidado
Authors: Martínez Rodriguez Ana , Olivé Ferrer Mª Carmen
Published: November 2021

La propuesta muestra el diálogo que se establece entre dos profesoras y unos textos de reflexión crítica, elaborados por el estudiantado de primer curso del grado de enfermería, en la asignatura Fundamentos históricos, teóricos y metodológicos. El objetivo general es exponer, mediante narrativa libre, dialógica y reflexionada, la consciencia de aprendizaje, a la vez que se reflexiona quien es el otro, tanto en la relación pedagógica como en el cuidado. Se describen los saberes docentes y enfermeros. Como experiencia docente se anota la organización de la asignatura, intercalando, a modo de narrativa libre, verbatims de los escritos del estudiantado y la reflexión de las profesoras. A modo de conclusión podemos decir que se cubren los objetivos de aprendizaje, se inician en los saberes, se reconocen como futuros profesionales e identifican al otro en la relación de cuidado.
Metodologías activas desarrolladas en la supervisión de las Prácticas Externas del Grado en Pedagogía
Authors: Rodríguez-Gallego Margarita R. , Ordóñez-Sierra Rosario
Published: November 2021

El presente trabajo muestra nuestro quehacer docente en el ámbito de la innovación con la materia Prácticas Externas en el Grado en Pedagogía de la Facultad de Ciencias de la Educación en la Universidad de Sevilla. A lo largo de este tiempo siempre hemos planteado dicha materia como el eje vertebrador de la formación inicial del pedagogo y pedagoga, siendo el estudiante el principal objeto de preocupación y enfoque. Detallamos diferentes metodologías activas implementadas para la supervisión de las Prácticas Externas: Programa de Acción Tutorial entre Iguales (PATI), Círculos de Calidad, seminarios y blog como herramienta colaborativa. Los estudiantes destacan un alto grado de satisfacción con las experiencias desarrolladas, al reducir las distancias entre el tutor y tutorizado, favorecer la evaluación individualizada de los trabajos de grupo, estimular el trabajo colaborativo, fomentar la reflexión, y ampliar su bagaje de conocimientos al interactuar con sus compañeros y compañeras. En definitiva consideran que son metodologías adecuadas por promover una organización horizontal del trabajo en la asignatura Prácticas Externas.
Wavelength and pulse energy optimization for detecting hypoxia in photoacoustic imaging of the neonatal brain: a simulation study
Authors: Mahmoodkalayeh Sadreddin , Kratkiewicz Karl , Manwar Rayyan , Shahbazi Meysam , Ansari Mohammad Ali , Natarajan Girija , Asano Eishi , Avanaki Kamran
Published: November 2021

Cerebral hypoxia is a severe injury caused by oxygen deprivation to the brain. Hypoxia in the neonatal period increases the risk for the development of neurological disorders, including hypoxic-ischemic encephalopathy, cerebral palsy, periventricular leukomalacia, and hydrocephalus. It is crucial to recognize hypoxia as soon as possible because early intervention improves outcomes. Photoacoustic imaging, using at least two wavelengths, through a spectroscopic analysis, can measure brain oxygen saturation. Due to the spectral coloring effect arising from the dependency of optical properties of biological tissues to the wavelength of light, choosing the right wavelength-pair for efficient and most accurate oxygen saturation measurement and consequently quantifying hypoxia at a specific depth is critical. Using a realistic neonate head model and Monte Carlo simulations, we found practical wavelength-pairs that quantified regions with hypoxia most accurately at different depths down to 22 mm into the cortex neighboring the lateral ventricle. We also demonstrated, for the first time, that the accuracy of the sO2 measurement can be increased by adjusting the level of light energy for each wavelength-pair. Considering the growing interest in photoacoustic imaging of the brain, this work will assist in a more accurate use of photoacoustic spectroscopy and help in the clinical translation of this promising imaging modality. Please note that explaining the effect of acoustic aberration of the skull is not in the scope of this study.
Spatiotemporal refraction of light in an epsilon-near-zero indium tin oxide layer: frequency shifting effects arising from interfaces
Authors: Bohn Justus , Luk Ting Shan , Horsley Simon , Hendry Euan
Published: November 2021

When light travels through a medium in which the refractive index is rapidly changing with time, the light will undergo a shift in its frequency. Significant frequency shifting effects have recently been reported for transparent conductive oxides. These observations have been interpreted as emerging from temporal changes to the propagation phase in a bulk medium resulting from temporal variations in the refractive index. It is an effect referred to as temporal refraction. Here, we show that the frequency shift in an epsilon-near-zero layer made of indium tin oxide originates not only from this bulk response but includes a significant effect resulting from temporal changes to the spatial boundary conditions. This boundary effect can lead to a dominant, opposing shift to the bulk effect for certain angles. Hence, this process gives rise to a frequency shift that can be tailored through the angle, decoupling the amplitude and phase modulation.