bluuebunny/crossref_metadata_2025 huggingface dataset:
Arguments of social media users regarding smoking cessation (machine learning-based data)
Authors:   Moscow State University named after M. V. Lomonosov, Kalabikhina Irina , Kazbekova Zarina ,   Moscow State University named after M. V. Lomonosov, Zubova Ekaterina ,   Cornell University
Published: December 2024

Introduction. The objectives of this research are: 1) to develop an algorithm for automating the social media users’ arguments regarding self-preserving behavior (motivation to continue or quit smoking); and 2) to structure the reasons to continue or quit smoking among the Russian-speaking users, based on testing the developed automation algorithm to rest the future arguments of demographic policy measures.
Materials and Methods. The algorithm to classify social media users’ arguments in favor of or against
smoking cessation was developed using natural language processing methods based on the Conversational
RuBERT neural model. The authors compiled a dataset of over 40,000 Russian-language comments posted
on YouTube for model training.
Results. A system of opinions among Russian-speaking YouTube users regarding self-preservation behavior was developed using thematic analysis of demographic content of search engines (concerning smoking cessation). According to our findings, health preservation is the predominant reason in arguments supporting smoking quitting, outweighing financial considerations. Additionally, the desire to avoid weight gain was identified as a reason some users choose not to quit smoking, although this factor is not a primary concern. On average, class prediction accuracy exceeds 85 %, indicating a high level of results reliability.
Conclusions. The algorithm developed by the authors for automating the arguments related to smoking
cessation provides real-time insights into the factors most strongly deterring Russians from smoking cessation (whether health concerns or cost of cigarettes) and the prevalence of certain myths about smoking cessation in the Russian society. The obtained data can be used to better tailor demographic policy measures aimed at reducing smoking prevalence in Russia, potentially leading to quicker and more effective outcomes.
Transactional configuration of innovative development of business ecosystem
Authors: Popov E. V. , Tikhonova A. D. , Zyrianov A. S.
Published: December 2024

Today, a business ecosystem has become a model that maximizes profits by creating a pool of key stakeholders and strengthening its position in the innovative economy. The authors believe that one of the ways to determine the order of stakeholder interactions in a business ecosystem based on digital platforms is assessment of the transaction costs associated with these interactions. The purpose of this study is to develop an algorithm for adjusting the institutional support structure of a business ecosystem in order to rationalize transaction costs and ensure the ecosystem growth. The neo-institutional approach and the theory of transaction costs were chosen as research methodologies, on the basis of which the findings obtained from the analysis were supported and adapted to the determinants of business ecosystem structures. This study presents a causal model of the relationship between transaction costs and interactions within a platform-based ecosystem. As a result, the authors have developed an algorithm that aims to create a pool of stakeholders in the business ecosystem in order to achieve sustainable development within the innovative economy through optimized transaction costs. This algorithm has been tested in the ENSONS company, serving as a testing ground for the research. The authors’ developments allow firms to combine information from various actors on the platform in order to comprehend complex interdependencies between participants, identify potential areas for cost reduction and efficiency improvement through coordinated service exchange.
The evolution of cutting technology and metal-cutting machines in the paradigm of technological modes
Authors: Kuznetsov A. P.
Published: December 2024

The article examines, from a historically foreseeable perspective, the technological methods of cutting and metal-cutting machines based on available literature. It summarizes and systematizes the directions and achievements of scientific research on cutting theory, as well as the creation of machine tools and their level of perfection. The goal of the study is to demonstrate, through the evidence from metal cutting machines, the significance and effectiveness of changes in economic development in relation to the technological mode. Using systems analysis, the level of development can be assessed based on the normative value of resource efficiency, which measures how well technology indicators are achieved through the design of machines and technological equipment. Factors that influence the formation of these indicators depend on technical and technological conditions and aim to achieve maximum values based on the technological capabilities for their implementation in industry and economy.
Methodological approaches to the institutional transformations for the formation and development of the scientific and industrial complex (on the example of the Republic of Belarus)
Authors: Shumilin A. G. , Ustinovich I. V.
Published: December 2024

Even large industrial enterprises do not have sufficient potential to implement large-scale innovation projects, which would allow, on the one hand, to ensure the high-tech products production and, on the other hand, to overcome the consequences of sanctions pressure. One of the possible ways to solve this problem is scientific-industrial integration, the end result of which in the Republic of Belarus can be an effectively functioning scientific-industrial complex. The aim of the study is to identify and evaluate methodological approaches to the institutional transformations for the formation and development of scientific-industrial complex. This article provides a description of the scientific-industrial integration theory and methodology, including: periodization and classification of scientific-industrial integration; comparative analysis of approaches to the scientific-industrial integration management; a set of economic relations, processes and phenomena that underlie scientific-industrial integration. On the basis of analyzing the foreign countries experience, the conclusion is made about the regulation of integration processes by the models and institutional environment of the country’s development. The unique role of the state in scientific-industrial integration of the Republic of Belarus is studied. The study of the concept and theory, which can be put at the basis of scientific-industrial complex, allowed to identify the criteria, prerequisites and principles of its formation.
Investigation of Epitaxial Misfit Strain Influence at the CsSn(I1-xBrx)3/SnO2 Interface on Photovoltaic Parameters in Cu2O/CsSn(I1-xBrx)3/SnO2 Perovskite Solar Cells
Authors: ARBOUZ Hayat
Published: December 2024

This work involves the numerical simulation of the photovoltaic performance of a single perovskite solar cell based on the Cu2O/CsSn(I1-xBrx)3/SnO2 structure, utilizing a lead-free inorganic perovskite absorber layer CsSn(I1-xBrx)3 with variable bromine content represented by the ratio x. The study aims to evaluate performance fluctuations due to misfit deformation effects at the interface between the SnO2 electron transport layer (ETL) and the absorber on photovoltaic parameters. The simulation model incorporates variations in the physical parameters of the device layers dependent on the ratio x. This enables the calculation of bandgap energy fluctuations according to strain theory and assesses the resultant impact on photovoltaic parameters due to strain at the SnO2/CsSn(I1-xBrx)3 interface. Performance results are presented as a function of bromine composition x, considering both the presence and absence of deformation effects. The study clearly demonstrates the significant impact of misfit deformation on bandgap energy fluctuation, emphasizing the need to optimize bromine content to balance deformation effects and achieve optimal performance. Specifically, the results show a maximum efficiency of 19.72% at x=0.56 for the undeformed structure, and 19.30% at x=0.50 for the deformed structure. This study refines simulation results and underscores the critical role of deformation engineering in modulating energy gaps.
(RE)SIGNIFICAÇÕES DE UM PROFESSOR SOBRE O ENSINO DE PRODUÇÃO TEXTUAL: RELATO-REFLEXIVO DE UMA EXPERIÊNCIA DE PESQUISA DE INTERVENÇÃO NA EDUCAÇÃO BÁSICA
Authors: Silva José Jilsemar da , Bessa José Cezinaldo Rocha
Published: December 2024

O presente texto constitui um relato reflexivo sobre nossa experiência de pesquisa desenvolvida no contexto do ensino de língua portuguesa na educação básica. Nosso objetivo é compartilhar avaliações apreciativas construídas a partir do trabalho com a produção textual em sala de aula durante a pandemia da COVID-19. Do ponto de vista metodológico, este trabalho configura-se como um estudo de natureza reflexiva, com viés narrativo, baseado em uma pesquisa de campo interventiva realizada em aulas de língua portuguesa na educação básica durante o período da pandemia. As reflexões apresentadas ao longo do texto, em diálogo com as ideias do Círculo de Bakhtin (Bakhtin, 2003; 2010; 2014; Volóchinov, 2018) e com os estudos de pesquisadores que discutem o ensino de língua portuguesa e a produção de textos (Antunes, 2003; Rojo, 2012; Geraldi, 2015; 2017, entre outros), bem como a formação de professores (Pimenta, 1999; 2019), evidenciam como o professor de língua portuguesa (re)significa sua relação com as aulas de produção de textos e com sua prática docente ao longo da experiência de intervenção realizada. Essa análise sinaliza o reconhecimento de limitações, desafios e aprendizados que resultaram de uma proposta de trabalho a qual assumiu a perspectiva processual da escrita e a dimensão dialógica como princípios basilares da prática docente.
REPRESENTAÇÕES SOCIAIS DE VIOLÊNCIAS: SEU ESTADO DA ARTE E UM ESTUDO DE CASO A PARTIR DE EXPERIÊNCIA SOCIOEDUCATIVA EM SÃO GONÇALO-RJ
Authors: Lopes Lucas Salgueiro , Vianna Ferreira Arthur
Published: December 2024

Este estudo aborda as representações sociais de violências, analisando o estado atual das pesquisas em Teoria das Representações Sociais (TRS) sobre esse fenômeno, e um estudo de caso em um projeto socioeducativo no Complexo do Salgueiro, em São Gonçalo-RJ. A pesquisa se fundamenta na necessidade de compreender as representações sociais da violência em contextos desafiadores marcados por desigualdades socioeconômicas e pela presença de altos índices de violências e criminalidade. O embasamento teórico inclui, sobretudo, os campos da Psicologia Social, Sociologia e Educação. Os objetivos principais foram: discutir a relação entre o fenômeno das violências a partir da Teoria das Representações Sociais; analisar a produção atual acerca das representações sociais de violências no Brasil; apresentar, como estudo de caso, alguns dos resultados principais de uma pesquisa acerca das representações sociais de violências realizada em um projeto socioeducativo em São Gonçalo. A metodologia envolveu pesquisa bibliográfica qualitativa – estado da arte – e a análise retórico-filosófica do discurso para desvelar as representações almejadas a partir dos diários de campo e entrevistas semiestruturadas. Os resultados revelaram lacunas na pesquisa acadêmica sobre representações sociais de violência, destacando a necessidade de investigações mais aprofundadas, especialmente em contextos pouco explorados como o estado do Rio de Janeiro e territórios favelados. As práticas socioeducativas observadas refletem as complexas representações de violência, destacando a percepção de desvio e ações de mitigação por parte dos educadores sociais. Conclui-se que as violências diretas e estruturais são amplamente reconhecidas, indicando desigualdades significativas na vida dos residentes do local investigado.
TURMA DA MÔNICA: UMA ANÁLISE DA CONSTRUÇÃO DOS PERSONAGENS HUMBERTO E SUELI
Authors: Corrêa Adriana Moreira de Souza
Published: December 2024

As Histórias em Quadrinhos são textos verbovisuais presentes no cotidiano das crianças e jovens, por isso, trabalhá-las no espaço escolar pode ser uma alternativa para abordar assuntos diversos. Deste modo, este artigo tem como objetivo discutir as percepções sobre a pessoa surda a partir da representação dos personagens Humberto e Sueli no que se refere a sua constituição e a sua participação em quatro histórias da Turma da Mônica, bem como os desafios para inseri-las nas aulas. Para isso, foi realizada uma pesquisa qualitativa com dados bibliográficos e documentais. Os resultados mostram que há uma inconstância nas características do personagem Humberto porque ele foi construído em um perspectiva clínico-terapêutica da surdez, que enfatiza a perda auditiva e as barreiras comunicativas que surgem em função da sua condição. Já Sueli representa a abordagem sócio-antropológica da surdez, pois se constitui em uma minoria linguística usuária da Libras. Logo, ao utilizar estes textos em sala de aula, é fundamental problematizá-los para desmitificar as ideias errôneas sobre o surdo de modo a favorecer a remoção de barreiras atitudinais e na comunicação e informação.
Análise cronológica das intervenções fisioterapêuticas nas disfunções temporomandibulares
Authors:   , Pereira Neto Débora , Moraes Evelyn Silva de , Amaral Marcela Macedo
Published: December 2024

Introdução: A disfunção temporomandibular (DTM) envolve alterações na articulação temporomandibular (ATM), afetando funções como mastigação e fala, e é uma das principais causas de dor crônica orofacial, afetando cerca de 75% da população adulta. Sua etiologia é multifatorial, englobando predisposições genéticas e hábitos diários. O tratamento requer uma abordagem multiprofissional, integrando áreas como fisioterapia, odontologia e psicologia. Intervenções fisioterapêuticas, incluindo cinesioterapia, eletroterapia e técnicas como terapia a laser de baixa intensidade (TLBI) e acupuntura, têm se mostrado eficazes na redução dos sintomas e na melhoria da qualidade de vida dos pacientes. Objetivo: Analisar a evolução do tratamento da DTM, identificando mudanças nas abordagens terapêuticas e avaliando a eficácia das estratégias de tratamento ao longo do tempo. Métodos: Essa revisão bibliográfica inclui estudos que analisam intervenções terapêuticas para DTM. Foram utilizadas as bases PubMed e PEDro, resultando em 9 estudos no período de 1999 a 2024. Os artigos foram organizados por intervenções, permitindo uma análise cronológica das mudanças nas práticas clínicas e a incorporação de novas abordagens terapêuticas ao longo do tempo. Resultados: Os estudos analisados sobre DTM e dor miofascial indicam que intervenções como acupuntura, TLBI e exercícios terapêuticos são eficazes na redução da dor e na melhora da abertura bucal. A intervenção cognitivo-comportamental (CC) também se mostrou benéfica, especialmente associada à correção postural. Conclusão: A análise cronológica das intervenções para DTM mostra uma evolução, desde tratamentos farmacológicos e cirúrgicos até abordagens menos invasivas como TLBI e acupuntura, que associadas a exercícios terapêuticos e outras abordagens, oferecem benefícios no alívio da dor e melhora funcional. Atualmente, o tratamento é multidisciplinar, focando tanto nos sintomas quanto na reabilitação funcional. O futuro requer continuidade nas pesquisas e adaptação das técnicas, com a fisioterapia explorando terapias inovadoras e personalizadas.
Análise cronológica sobre das intervenções fisioterapêuticas em mulheres pós mastectomizadas
Authors:   , Kadimura Cassiane Harumi , Sousa Larriane Roma de
Published: December 2024

Introdução: Os tumores de mama são comuns, e representam o tipo de câncer que mais afeta mulheres no Brasil, de acordo com o Instituto Nacional de Câncer (INCA, 2022). A intervenção mais recomendada é a mastectomia, e por ser um procedimento cirúrgico invasivo, pode causar efeitos colaterais que impactam diretamente a qualidade de vida dessas pacientes. As intervenções fisioterapêuticas desempenham um papel importante no alívio dos sintomas pós-cirúrgicos e no retorno às atividades de vida diária. Objetivo: Avaliar as diferentes intervenções fisioterapêuticas ao decorrer dos anos em mulheres diagnósticadas com câncer de mama que realizaram mastectomia e apresentaram disfunção em membro superior. Métodos: Foi realizada uma revisão bibliográfica de literatura nas bases de dados PubMed via Medline, PEDro e Cochrane no período de agosto e setembro de 2024. Foram incluídos ensaios clínicos randomizados e não randomizados com texto gratuito e disponível. Resultados: Dos 162 artigos selecionados, apenas 11 estudos conteplaram os critérios de inclusão, pois citavam as intervenções fisioterapêuticas e função do membro superior. Conclusão: Esta análise cronológica demonstra a evolução das intervenções fisioterapêuticas que beneficiam o tratamento de pacientes mastectomizadas. Atualmente as evidências apontam que as intervenções quando feitas em conjunto trazem melhorias no manejo pós-cirúrgico e na reabilitação funcional desta população.
Análise cronológica dos recursos auxiliares e intervenções fisioterapêuticas utilizadas durante o treinamento de marcha e funcionalidade em crianças e adolescentes com paralisia cerebral: uma revisão bibliográfica
Authors:   , Lopes Izadora da Silva , Queiroz Janaina dos Anjos C. de , Soares Neto  Olavo Lazaro Munhoz
Published: December 2024

Introdução: A Paralisia Cerebral (PC), descrita inicialmente por William John Little, no século XIX como uma desordem do sistema motor recorrente a uma lesão encefálica primária, tem caráter crônico e mutável, gerando alterações musculoesqueléticas secundárias. A prevalência global de PC é de 1,5 a 3 por 1.000 nascidos vivos. A classificação da PC inclui as formas clínicas espástica, extrapiramidal, atáxica e mistas. Objetivo: Verificar temporalmente quais recursos auxiliares e intervenções fisioterapêuticas foram empregadas durante o treino de marcha e funcionalidade em crianças e adolescentes com PC. Metodologia: Uma revisão bibliográfica utilizando as bases de dados MEDLINE via PubMed e PEDro. Com critérios de inclusão:a) ensaios clínicos e ensaios clínicos randomizados, b) qualquer idioma e c) sem restrição quanto a data de publicação. Resultados: Dezoito estudos atenderam os critérios de elegibilidade e encontramos as seguintes intervenções: uso da toxina botulínica A (3), estimulação elétrica neuromuscular (1), treinadores de marcha (2), pedômetro (1), treinamento em esteira com e sem suspensão corporal (2), plataforma de vibração (1), estimulação transcraniana por corrente contínua (3), palmilha postural (1), treino de caminha para trás (1), fortalecimento dos músculos do tronco (1), exercícios pliométricos (1) e tecnologia robótica (1). Conclusão: A análise temporal permite identificar que a utilização de recursos auxiliares no treino de marcha e funcionalidade em crianças e adolescentes com PC evoluiu com a tecnologia acrescentando os seguintes recursos: esteiras ergométricas com ou sem suspensão corporal, treinadores de marcha, plataforma vibratória, tDCS anódica, palmilhas posturais, realidade virtual e tecnologia robótica. As intervenções fisioterapêuticas permaneceram inalteradas ressaltando a utilização de exercícios de alongamentos, fortalecimento e treino de trocas posturais.
Recognition of Weeds Associated with Coffee Crops by Use of Co-occurrence Matrices, Texture Analysis and Machine Learning
Authors: Muñoz Neira Milton Javier
Published: December 2024

The present work presents the results of twenty-four experiments realized for recognition of two classes of weed leaves associated with coffee crops. 210 images were acquired, 70 for each weed class, and 70 for coffee leaves samples. All images were processing and transformed into HSV color format. From each image, 33 texture patterns were extracted, which were reduced to four through principal component analysis. The fractal dimension was added as a fifth pattern. The recognition was done through the implementation of three machine learning techniques, support vector machine (SVM), k-near neighbors (KNN), and artificial neuronal network.  Machine learning techniques permitted classification with precision and recall upper or equal to 95%, on average, when the fractal dimension was not used, and upper or equal to 97% on average when the fractal dimension was used. SVM and ANN were methods with better outcomes. Experiments constitute a first approximation to the implementation of an automatic system for selective weed eradication in a coffee crop.
CONCEPÇÕES SOBRE CIÊNCIA E CIENTISTA EMERGENTES DE UM PROCESSO DE CIÊNCIA CIDADÃ COCRIADA EM ESCOLA
Authors: Dutra Gonzalez Janaina , Pirani Ghilardi-Lopes Natalia
Published: December 2024

Establishing a broad understanding of science and the role of scientists by Elementary School students is challenging, but essential. In the context of Science teaching, it is an objective to understand how scientific knowledge is produced and who are those responsible for knowledge construction. This study aimed to investigate whether there were changes in the conceptions of science and scientists among 3rd-grade elementary school students participating in a citizen science project in the school context. Field research was conducted in 2022, with participant observation and a quali-quantitative approach, involving 96 students from a full-time school in the ABC Paulista region. A shift from alternative conceptions to less stereotypical and more realistic views of the scientific process was observed. An increase in the understanding of the relationship between science and the practice of asking questions was noted. The results suggest that co-created citizen science teaching and learning approaches at schools can be effective in promoting a solid scientific education from the early years of elementary school. Thus, we emphasize the importance of investigating innovative proposals in Basic Education, aiming at the progressive construction of students' understanding of science and scientific work.
O DISCURSO ACADÊMICO SOBRE O PROFESSOR BACHAREL QUE ENSINA CIÊNCIA E TECNOLOGIA NOS CURSOS DE EDUCAÇÃO PROFISSIONAL INTEGRADA AO ENSINO MÉDIO
Authors: Alarcon Fioratti Netulio , Aparecida Della Justina Lourdes , Maria Strieder Dulce
Published: December 2024

The subjective constitution of the bachelor as a science and technology teacher in Professional Education courses Integrated into High School is a question of evident complexity, often introduced by the lack of initial training in specific teacher training courses. In this post-critical research, we present a Foucauldian discursive study that used articles published from 2016 onwards to deal with the aforementioned professor. We developed the analysis based on concepts present in The Order of Discourse and identified, in the aforementioned enunciative materiality, elements that outline the subject position and potentially constitute it. Topics were covered involving the interdiction and segregation of bachelors as science and technology teachers, whether due to the existence of a will to truth, disciplinary knowledge or rituals in which this subject participated or not. We also highlight elements that contribute to the constitution of this teacher, such as their prior knowledge and knowledge, which are unique and inherent to their initial training.
A Correlation Analysis of the KAP Model against Online Scam Crimes in Malaysia
Authors: Mohd Hasini Noor Fariza , Shahrul Azmi Salbiah Nur , Jais Zurairah , Samsudin Shahrul Niza , Izhar Nor Izzuani , Idris Nor Ainee , Abu Hassan Azwan Amirulsyafiq
Published: December 2024

This study aims to analyze consumers’ Knowledge, Attitude, and Practices (KAP) Model of online scam crimes in Malaysia following the increase in crime cases that have become a concern. By using a quantitative approach, data were collected through questionnaires and analyzed by using SPSS software to identify the relation between demography, internet usage, and consumers’ cautious behavior. The KAP Model is adopted as the main framework to comprehend the consumers’ interaction with their digital surroundings. The findings of this study show there are positive correlations between age, education, and awareness of online scam crimes. The findings also found that there are strong relations between internet users and social media with consumers’ preventive behavior. This study aims to identify the gap in the literature about psychosocial factors that influence consumers’ awareness. The result of this study is hoped to be a guide to the policymakers and the authorities in designing more effective prevention strategies to protect consumers from the threat of online scams as well as enhance digital literacy among Malaysians.
Rationale for Selecting Taiping, Perak as a Study Location for Ageing: A Conceptual Framework for Age-Friendly Cities
Authors: Mohd Yusof Noorlailahusna , Mat Yasin Suziana
Published: December 2024

This conceptual paper explores the rationale for selecting Taiping, Perak, Malaysia, as a study location for ageing research within the framework of the World Health Organization's (WHO) Age-Friendly Cities and Communities (AFCC). Taiping’s rich historical and demographic context and designation as the pilot site for Malaysia’s Age-Friendly City initiative in 2019 highlight its potential as a model for studying ageing in place. This research aims to analyse Taiping's unique characteristics, such as its ageing population, urban design, and social structures, to evaluate its readiness to meet the needs of older adults. The study highlights key factors influencing Taiping’s selection, including community support systems, social participation opportunities, accessible infrastructure, and alignment with WHO’s eight AFCC domains. Preliminary findings suggest that while Taiping exhibits promising features, such as strong community engagement and a well-preserved historical environment, gaps remain in integrating age-friendly practices and policies. This paper addresses these gaps by proposing a conceptual framework tailored to Taiping’s context, aiming to enhance urban planning and policy development for ageing populations. By doing so, it contributes to the global discourse on age-friendly urban environments and offers practical implications for policymakers in Malaysia and beyond.
Building bridges from research outcomes to clinical practice decisions
Authors: Chambers David W. , Flores-Mir Carlos
Published: December 2024

Practitioners may face difficulties implementing research results into practice. Seven examples of common knowledge translation barriers for clinicians are presented, and suggestions are offered for building effective communication bridges. Changes in how research results are reported and interpreted across different practice contexts can improve orthodontic care. These include (a) attention to the expected benefit that includes estimates of both likely clinical value and probability of occurrence, (b) cost considerations, (c) generalizability across contexts that require interpretation adjustments, (d) measures of effect size in addition to measures of statistical significance, (e) determination of the largest relative sources of variance in the reported results, (f) estimating probabilities that lead to practice actions, and (g) conversion of research descriptions to values that impact practice decisions. Examples of improved communication relevant to clinicians are provided that can be used to build stronger bridges between orthodontic research and practice. Although advances in orthodontic research rigor have been noted, journal articles would benefit from more clinician-friendly descriptions of results and their impact.
Pharmacokinetics of the Tyrosine Kinase Inhibitor, Alectinib
Authors: I* Al-Ani , T Ata , E Daoud , SF Hassan
Published: December 2024

In 2015, the FDA authorized the use of a new tyrosine kinase inhibitor, Alectinib (ALB), for the intracellular domain of anaplastic
lymphoma kinase with exo-cranial pointed mutations. Alectinib became the first drug to be licensed in the first line in August
2017. Its pharmacological properties differ from those of its predecessors, and new research is needed to identify the potential
pharmacological and clinical implications. This review presents a critical analysis of the pharmacokinetics of Alectinib and its
impact on hepatobiliary metabolism. We present current clinical data and new knowledge that could be developed for further
clinical research. With this study, we hope to identify perspectives that can further prolong the efficacy of the anaplastic
lymphoma kinase (ALK) tyrosine kinase Alectinib. Tyrosine kinases with receptors for the ligands of platelet growth are a
class of enzymes with a key position in the pathogenesis of various molecular alterations that drive idiopathic cancers. The
different characteristics of these kinases make them currently a preferential target for the design of new cancer inhibitors. A
clear example of their efficiency is the landmark obtained in patients bearing tumors with intronic rearrangements or ALK
translocations. These tumors are mostly found in subjects suffering from non-small-cell lung cancer with adenocarcinoma
histology and not of the non-smoking type. Moreover, the development of different resistance mechanisms designated
allosteric through targeted second-line interventions has culminated in a marked increase in patient survival.
Design for the Body: How Ergonomics Transforms Modern Clothing into Comfortable, Functional, and Stylish Garments
Authors: S Das
Published: December 2024

Clothing ergonomics, an interdisciplinary field blending ergonomics, anthropometry, and fashion design, revolutionizes the
relationship between clothing, the human body, and the environment. By emphasizing human-centered design, it ensures
garments are not only visually appealing but also functional, comfortable, and tailored to users’ needs. This study explores the
application of ergonomic principles in fashion design, focusing on usability, functionality, and aesthetic harmony. It highlights
the significance of anthropometric data in designing clothing that aligns with the body’s natural movements, improving safety,
health, and comfort. The research examines the evolution of ergonomic design in fashion, from historical shifts in women’s
clothing to modern advancements in material science and user-centric methodologies. Special attention is given to critical
design zones, including necklines, shoulders, and sleeves, ensuring seamless interaction between garments and wearers.
Fashion design is pivotal in blending aesthetics with functionality, particularly in addressing the physical relationship between
clothing and the human body. The six foundational pillar safety, health, comfort, functionality, aesthetics, and individuality—
are emphasized as essential principles for innovative and impactful design. This integration of science and creativity fosters
garments that resonate with diverse user expectations, aligning functionality with symbolic and emotional dimensions. The
findings underscore the transformative potential of clothing ergonomics in creating wearable solutions that merge aesthetic
allure with practical usability, elevating modern fashion to new standards of excellence.
The Evolution of Criminal Profiling in the Digital Age: An Approach from Clinical Forensic Psychology
Authors: Mateo-Fernandez Pedro V
Published: December 2024

In the past decade, digitalization has profoundly transformed the field of clinical forensic psychology. This article explores
how technological advancements, particularly in artificial intelligence (AI) and social media analysis, have influenced the
creation of criminal profiles and the methodologies used to understand offenders in a digitized world. Findings reveal that AI
algorithms can identify behavioral patterns that might go unnoticed by human investigators, enhancing early threat detection
and the accuracy of criminal profiles. Additionally, analyzing behaviors on social media provides deeper insights into the
interactions and motivations of offenders. Interdisciplinary collaboration among experts in cybersecurity, data analysis, and
sociology has enabled the development of more sophisticated and accurate models. However, digitalization also poses ethical
and psychological challenges, such as privacy protection and the mental health of forensic investigators. Future research should
focus on improving AI tools, fostering interdisciplinary collaboration, and addressing the ethical implications of digitalization.
In conclusion, the digital era has transformed clinical forensic psychology, introducing new tools and methodologies while also
presenting significant ethical dilemmas and the need for new competencies.
Unusual Gunshot Death and Contribution of Bloodstain Pattern Analysis in Determination of Manner of Death – Case Report
Authors: Todorović Stevan
Published: December 2024

Bloodstain Pattern Analysis (BPA) represents the examination of the shapes, sizes, locations and distribution of bloodstains
in order to provide an interpretation of the events that caused their uprise. The purpose of BPA is to draw conclusions about
the nature, timing and other details of the crime. When it comes to firearm fatalities, the main goal of forensic analysis is to
distinguish firearm suicides from homicides and accidents. We present a case of a 48–year man who was found in his camper
with a gunshot wound on the chest. At first glance, it looked like a homicide, because of the fact that the bullet was not found,
because of unusual position of death body and unusual distribution and amount of bloodstains. The autopsy revealed the
entrance wound on the front and the exit wound on the back side of the chest, with heart injury. BPA in synergy with autopsy
report revealed that gunshot took place in camper while a deceased was on a back seat of his vehicle in sitting position. Both
front and back slide doors were closed at time of discharge and subsequent bleeding, and there was no void in bloodstains to
indicate presence of second person. Finally, it was concluded that the manner of death of the deceased was suicide. According
to obtained results from expertise re-examination of the vehicle resulted in finding a bullet in a back-window rubber seal.
A Systematic Review on Molecular Pathophysiology Involved in Chronic Kidney Disease and the Role of Animal Models in Drug Discovery to Manage in Chronic Kidney Disease - An Update
Authors: UR* Sharma , S Sultana , RL Haripriya , A Ramachandran , R Borah , V Surendra , T Haribabu , N Taj , SV Gayathri , S Janadri , PM Manjunatha
Published: December 2024

Chronic kidney disease (CKD) is a life threatening condition that causes progressive loss of kidney function. It is one of the
leading causes of death and affects about 10% of the population worldwide. CKD poses a great challenge for societies as well
as health care systems. Currently, there are only a few treatments being developed for CKD, several of which have failed to
improve renal outcomes. CKD is caused due to multiple factors whose mechanism is incompletely understood. Hence, various
animal models have been established as an approach towards clarifying the pathogenesis and underlying mechanism of CKD.
In the present review, we discuss the possible mechanisms of CKD along with the animal models used to mimic the human
CKD in order to have a better understanding of generation and progression of CKD.
Diário da Navegação de Pero Lopes de Sousa (1530-1532)
Authors: Pereira Paulo Roberto
Published: December 2024

The mission to Brazil led by Martim Afonso de Sousa, 1530-1532. Pero Lopes de Sousa and his Navigation Journal. The fleet as a coastal defense, colonizing, and exploring force. Varnhagen and the discovery of the Journal. The importance of the Navigation Journal for Brazilian colonial history. The founding of the first town in Brazil, São Vicente, in 1532. Navigation Journal: the first document to describe the Río de la Plata estuary.
Extractivism, Profits and People: Environmental, Social and Economic Costs of Fluorspar Mining In Kerio Valley, Kenya
Authors: KIPKOSGEI EVELYN
Published: December 2024

This paper examines the disruptive effect of resource extraction through fluorspar mining in Kerio-Valley. Focus is on how this process sparked off economic contestations, intense ecological crisis, and heightened social tensions. The discovery and subsequent mining of Fluorspar deposits in Kerio Valley has created economic opportunities and caused profound challenges for the indigene Keiyo community. Mineral extraction has caused environmental degradation, deforestation, water contamination, cultural desecration, and land dilapidation, which has adversely affected local agriculture and biodiversity. One thousand four hundred families have suffered the disruption of traditional livelihoods occasioning food shortage and hunger, leading to the cultural disintegration of a once vibrant and self-sustained community. Despite government efforts to manage these impacts through various policies and partnerships with multinational corporations, the socio-ecological crises persist. Using grounded theory, this paper argues that the benefits of fluorspar mining is negated by the long-drawn demands for adequate compensation, pollution, and social upheaval. This paper recommends a re-evaluation of governance frameworks and corporate practices in the extractive sector.
Integrating Inquiry-based Learning in the New Greek Primary Science Curriculum
Authors: Kotsis Konstantinos T.
Published: December 2024

This study explores how inquiry-based learning (IBL) is incorporated into the recently implemented Greek primary science curriculum, emphasizing the vital role that IBL plays in fostering students' scientific literacy and critical thinking. The study presents a framework that enriches learning environments through hands-on, inquiry-driven methods, drawing insights from successful practices in various European educational contexts. The curriculum reforms are designed to bridge the gap between theoretical knowledge and practical application, equipping students with vital problem-solving skills for understanding complex scientific phenomena. The research underscores the essential role of continuous professional development in empowering educators to effectively implement these changes, ensuring they are confident in their teaching practices. Educators are the linchpin of this new curriculum, and their support is indispensable. The study also emphasizes the need for a customized implementation strategy that respects local cultural frameworks. This is not just a suggestion but a necessity, as it is crucial for promoting scientific inquiry. By incorporating IBL, the curriculum aims to prepare students for the challenges of a rapidly evolving world, fostering a culture of inquiry crucial for nurturing scientifically literate citizens. This approach enhances educational outcomes and encourages students to take ownership of their learning journey, promoting autonomy and personal investment in their education.
Lâmiî Çelebi Dîvânı nda Emîr Ahmed Buhârî
Authors: ÖZTOPRAK NİHAT , GÖKSU Rabia SEZER
Published: December 2024

Emîr Ahmed Buhârî’nin müritlerinden olan Lâmiî Çelebi onu yakinen
tanıyanlardan birisidir. Sağlığında ona intisap etmiş, sohbetlerine katılmış,
ondan el almıştır. Daha sonra kendisi de onun gibi Nakşi tarikatı şeyhliği
yapmıştır. Aynı zamanda büyük bir şair olan Lâmiî Çelebi, bilhassa Dîvân’ında
şeyhi Emîr Ahmed Buhârî’nin çeşitli vasıflarını, ona duyduğu derin sevgisini
ve bağlılığını, ondan beklentilerini ve taleplerini, ilmini, ahlâkını ve hizmetlerini
dile getiren şiirler kaleme almıştır. Bu makalede bu şiirler değerlendirilerek
Lâmiî Çelebi’nin gözünden Emîr Ahmed Buhârî tanıtılmaktadır.
Makalenin giriş kısmında hatırlatmak amacıyla Lâmiî Çelebi’nin
hayatı, eserleri ve edebî kişiliği kısaca tanıtılmıştır. Sonra Emîr Ahmed Buhârî
hakkında bilgi verilmiş, daha sonra Lâmiî Çelebi ile Emîr Buhârî arasındaki
ilişkiden söz edilmiştir. Bu kısımda tanışmaları, görüşmeleri vs. ilişkileri
hakkında kısaca bilgi verilmiştir. İkinci bölümde ise Lâmiî Çelebi’nin Emîr
Buhârî hakkındaki düşünceleri, Dîvân’ındaki şiirlerinden hareketle
değerlendirilmiştir. Dîvân’ında müstakil bir bölüm içinde onun için yazılmış 28
gazel yer almaktadır. Lâmiî Çelebi, Emîr Buhârî’yi Dîvân’ında “Mîr, Mîr
Efendi, Buhârî, Mîr-i Buhârî, Mîr Sultan” kelimeleriyle zikretmiş, çeşitli
vasıflarından dolayı da onu “yâr, dildâr, merdân, mâşûk, hâce, şehenşâh,
gamhâr, sevgili, Humâ, simurg, âfitâb, kitap, kâmil, gönül mimârı, dost vb.”
sıfatlarla anmıştır.
Lâmiî Çelebi, Emîr Buhârî’nin örnek davranışlarını, örnek ahlâkını,
sohbetlerini, nasihatlerini anlatmanın yanında ondan beklentilerini dile
getirmeyi ve halini arz etmeyi de ihmal etmemiştir. Emîr Buhârî’yi sağlığında
yakinen tanıyan, kalem ehli canlı şahitlerdendir. Bu sebeple onun Emîr Buhârî
hakkında verdiği bilgiler son derece kıymetlidir.
Klasik Türk Mûsıkîsi Eserlerinin Türkçe Güftelerinin Şair, Kaynak ve Metin Bakımından Dört Eser Üzerinden Değerlendirilmesi
Authors: ÇIPAN MUSTAFA
Published: December 2024

Klasik Türk Mûsıkîsinin temel vasfı, estetik ile faydayı birlikte mütâlaa
etmesi, nağmenin yanında güfteye de büyük önem vererek insan sesini öne
çıkarması ve repertuvarındaki eserlerin çok büyük bir kısmının sözlü eserler
olmasıdır. Şiir ile nağme, birbirini tamamlamak suretiyle mûsıkî eserini
meydana getiren iki aslî unsurdur.
Güfte varlığımızı tespit bakımından kütüphanelerde ve özel
koleksiyonlarda binlerce el yazması ve matbu güfte-şiir mecmuası ile dîvân
çok zengin bir kaynak mevcudunu meydana getirmektedir. Özellikle yeni
harfli güfte mecmualarında ve nota altı güfte yazımlarında pek çok hata,
eksiklik ve farklılık vardır. Eserlerin büyük bir bölümünün de güfte şairleri
henüz tespit edilebilmiş değildir.
Genel durum hakkında bir fikir verebilmek maksadıyla bu makalede,
Klasik Türk Mûsıkîsi takımlarını meydana getiren eserlerden dördü
üzerinde durulmuştur. Makam / usûl / form / bestekâr, vezin, nazım şekli
yazılmış, bestelenmek üzere seçilen beyit veya bendler, bestekârın güfteyle
ilgili yapmış olduğu tercih ve tasarruflar, güftelerde meydana gelen tahrifat
anlatılmıştır.
Güftelerin hem antolojilerde hem de nota altlarında nazım şekilleri
gözetilmeden, bütün mısrâlarının eşit aralıklarla yazılmış olmasının, nazım
şekillerinin tespitinde ve güfteye anlam vermede zorluklar oluşturduğu göz
önüne alınarak bu dört eserde gerekli hassasiyet gösterilmiştir.
Güfte metinlerinin imlâsında vezne uygunluğu ve doğru okuyabilmeyi
sağlamak için gerekli olan noktalama işaretleri belirtilmiş, bazı kelimelerin
imlâsı da günümüz telaffuzuna uygun şekilde yazılmıştır.
Denizden Karayı Görmek: Bir Kronotop Olarak Modern Türk Öyküsünde Vapurda Karşılaşma Anı
Authors: KOÇYİĞİT DEMET
Published: December 2024

Zaman ve mekân, kurguya dayalı metinlerin yapısı incelenirken dikkate alınan
temel unsurlardan olagelmiştir. Kurguda anlatılanların ne zaman ve nerede
geçtiğinin tespiti metnin anlamlandırılması veya bir bağlama oturtulması
açısından önem arz eder. Mihail Bahtin kurguya dayalı metinlerin varoluş
biçimini tartışırken zaman ve mekân unsurlarına farklı ve derinlikli bir rol
yükler. Zira onun kronotop düşüncesinde zaman ve mekânın birlikteliğiyle
oluşan odaklar etrafında kurgu değerlendirilmektedir. Bahtin kurguyu temelden
etkileyen kronotoplardan ve kurguyu yönlendiren kronotoplardan söz etmektedir.
Karşılaşma kronotopu da kurguyu yönlendiren, bir dönemeç etkisine sahip olan
kronotoplardandır. Bu çalışma, Bahtin’in kronotop kavramından hareketle
modern Türk edebiyatında vapurlarda geçen öyküleri karşılaşma kronotopu
açısından ele almaktadır. Modern Türk öyküsünde sıkça görülen vapurlar,
insanları bir zaman dilimi içinde beraber tutan sınırlı mekânlar olma özelliği
açısından Mihail Bahtin’in kronotop kavramı etrafında incelemeyi mümkün
kılmaktadır. Çalışmada karşılaşmadan kastedilen, vapurun limandan ayrılırken
veya limana yanaşırken mekânla karşılaştığı andır. Burada odaklanılan mesele ise
Bahtin’in metin içinde dönemeçleri oluşturduğunu iddia ettiği karşılaşma
kronotopu bağlamında vapurun dışındaki mekânla vapurda karşı karşıya gelme
anının kurguyu nasıl etkilediğidir. Makalede bu karşılaşma anının öyküde
kurucu veya değiştirici bir etkiye sahip olma eğilimi 20. yüzyılda kaleme alınmış
olan Türk öykülerinden hareketle tartışılmaktadır. Bu amaçla çalışma Bahtin’in
kurguda kronotopun gerçeğe yakın veya gerçeklikten uzak olabileceği görüşünü
kabul etmekle beraber karşılaşma kronotopunu gerçeğe yakın biçimde işleyen
öykülere yer vermekte, öykülerde karşılaşma anında beliren duygu veya
düşüncelerle bunlara bağlı nitelemelerin öykülerin genel yapısıyla ne kadar
ilişkili olduğunu tespit etmeyi hedeflemektedir. Böylece bu çalışmada vapurda
karşılaşma anı kronotopunun modern Türk öyküsünde nasıl bir role sahip olduğu
sorusuna cevap aramaktadır
The attitude of young doctors toward patient-centred medical care
Authors: Mylnikova IS , Mylnikova MA , Shkolnikova EA
Published: December 2024

Patient-centredness is a relatively new proof-of-concept setting associated with the concept of quality of medical care, which gradually becomes a new moral standard of medical practice. We conducted a study of the attitude of the younger generation of doctors (graduate students and residents of the Pirogov Russian National Research Medical University and RUDN, 2024) towards patient-centredness. They were offered a questionnaire consisting of 21 questions on different aspects of patient-centred communication. 155 completed questionnaires were received. The answers indicated that many young doctors are familiar with the concept of patient-centred approach and practice patient-centred communication skills. At the same time, many people feel a lack of training in this area and realize their vulnerability in communicating with the patient. At the same time, the survey revealed paternalistic attitudes in more than half of the respondents. It can be concluded that young doctors need not only mastering the skills of patient-centred communication, but also a deeper study of the moral foundations of patient-centredness, which can be implemented within the training courses in bioethics, as well as while teaching clinical disciplines.
رۆڵی پلاتفۆڕمەكانی سۆشیاڵ میدیا لە زیادبوونی هەراسانكردنی كچان لە هەرێمی كورستاندا
Authors: Mawlod Dlan I. , Jabar Abeer M. , Ahmad Mohammed O.
Published: December 2024

توێژینەوەكان ئەوە پشتڕاستدەكەنەوە، كە هەراسانكردن دیاردەیەکە لە زۆرێك لەوڵاتانی دنیادا بەربڵاوە بەتایبەت لەسەردەمی تۆڕەکۆمەڵایەتییەکاندا، شێوازەكانی هەراسانكردن زیاتر هەستپێكراوترە، ئەم توێژینەوەیە بەدواچوونێک دەکات سەبارەت بەوەی کە چۆن پلاتفۆرمەكانی سۆشیاڵ میدیا لە هەرێمی کوردستاندا دەبنە سەکۆیەک بۆ زیادبوونی دیاردەی هەراسانكردنی كچان. ئامانجی سەرەكی توێژینەوەكەش بریتییە لەخستنەڕووی ڕۆڵ و کاریگەریی و لێێكەوتەكانی، پلاتفۆرمەكانی سۆشیاڵ میدیا لە تەشەنەکردنی دیاردەی هەراسانكردنی كچان لای بەكارهێنەری هەرێمی كوردستاندا، لەم توێژینەوە میتۆدی(وەسفی-بەرێگەی رووپێوی)بەكارهاتووە بۆ باس كردن وهەڵسەنگاندنی رادی كاریگەری پلاتفۆرمەكانی سۆشیال میدیا لە زیادبوونی هەراسانكردن ئەمەش لەڕوانگەی سامپڵێك لە كچانی نیشتەجێی سەنتەری شاری هەولێر, دەڤەری سۆران، كە ژمارەیان (255)كچە قوتابی بوون لە قوتابخانە ناوەندی و ئامادەییەكان. هەروەها توێژینەوەکە پەنجە دەخاتەسەر كاریگەریەكانی ئەو هەراسانكردنانە كە لەسەر ژیانی كۆمەڵایەتی و دەروونی كچان دروستی دەكات، لە دەرەئەنجامدا دەركەوتووە كە زۆرینەی كچان پلاتفۆرمەكانی سۆشیاڵ میدیا بەكاردەهێنن و تێیدا توشی هەراسانكردن دەبنەوە، بەتایبەت لە تۆڕی سناپچات بەهۆی ئەوەی بەربڵاوترینە لە بەكارهێناندا لەلایەن كچانەوە.