bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of various cleaning solutions on the geometry, roughness, gloss, hardness, and flexural strength of 3D-printed zirconia
Authors: Cai HongXin , Lee Min-Yong , Jiang Heng Bo , Kwon Jae-Sung
Published: June 2024

Objective:This study aimed to investigate the impact of various cleaning solutions on the geometry, roughness, gloss, hardness, and flexural strength of 3D-printed zirconia.
Methods: Cleaning solutions, including isopropyl alcohol (IPA, 99.9%), ethyl alcohol (EtOH, 99.9%), and tripropylene glycol monomethyl ether (TPM, ≥ 97.5%), were diluted to a concentration of 70% and categorized into six groups: IPA99, EtOH99, TPM97, IPA70, EtOH70, and TPM70. Zirconia discs, printed via digital light processing, were sintered after cleaning. The geometry, roughness, gloss, hardness, and flexural strength were analyzed. Statistical analysis was performed using one-way ANOVA with Tukey’s post hoc test (α < 0.05).
Results: The thickness of TPM70 was the highest. The diameter of TPM70 was significantly larger than that of EtOH99 and IPA70 (α < 0.05). The weight of the TPM groups was significantly higher than that of IPA70 (α < 0.05). The roughness Ra of TPM70 was significantly greater than that of IPA99, EtOH99, and EtOH70 (α < 0.05). The differences between the surface roughness, gloss, and flexural strength values of different groups were not statistically significant (α > 0.05).
Significance: Different cleaning solutions did not affect the surface gloss, hardness, and flexural strength of 3D-printed zirconia. High and low concentrations of the same cleaning solution did not affect the surface gloss, hardness, and flexural strength. IPA70, TPM97, and EtOH can be considered viable post-printing cleaning alternatives to the traditional gold standard, IPA99.
Determination of Glucose Oxidase Activity of Flour Additive by Fluorescence Quenching Method
Authors: Dong Na , Zhang Aiju , Zhang Xiaolin , Dai Xingde , He Fangzhen
Published: June 2024

Glucose oxidase can catalyze the reaction of glucose to produce hydrogen peroxide, and hydrogen peroxide reacts with excess I− anions in dilute sulfuric acid solution to form I3−. The I3− combines with Rhodamine 6G to form association which result in fluorescence quenching. Effect of glucose oxidase on fluorescence of Rhodamine 6G, a new method with high sensitivity and good selectivity for the determination of glucose oxidase activity was established. Under the optimal conditions, the linear range of the method is 1.0×10− 4-1.0×10− 1 U/mL, and the detection limit is 9.0×10− 5 U/mL. This assay was applied to the determination of glucose oxidase activity in the food additives samples with satisfactory results, the recoveries obtained were 95.33%-102.5%.
An Hybridization Method of Clustering Images Using Artificial Ants Model (CLAntIMG)
Authors: Masmoudi Nesrine , Ayadi Manel , Salhi Amina , Almuqren Latifa
Published: June 2024

Image clustering is an unsupervised learning task that primary function is to categorise and extract the image's valuable attributes. Many techniques like data augmentation and normalization or meta-heuristic algorithms like swarm intelligence can be used to improve the clustering performance.
This research proposes an hybrid Ant Colony Optimization (ACO) algorithm, named CLAntIMG, based on the KMeans method to improve image clustering performances grouping structured and unstructured data components. The algorithm takes a distance matrix and an initial pheromone matrix as input and returns the best route found by the KMeans algorithm, representing the centroids of the clusters. This method computes pairwise distance matrices using different metric distances (Euclidean, Manhattan, Chebyshev). In addition, a proposed matrix containing dimensional characteristics with extracted features based on Local Binary Pattern (LBP) is applied to extract features from the images, and the resulting dimensional characteristics. These LBP features provide texture information that can enhance the clustering process by considering both spatial and texture-based dissimilarities between data points.
The efficiency and robustness of the proposed CLAntIMG algorithm compared with other algorithms demonstrate its ability to find optimal cluster assignments even with different initial parameters. The performance of each cluster is evaluated using the Silhouette score, the Calinski-Harabasz index and the normalized mutual information (NMI) leading to promising results, notably with the Chebyshev distance, reaching an NMI of 0.94 on the Iris dataset.
Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells
Authors: Young Kristen S. , Hancock Govinda R. , Fink Emma C. , Zigrossi Alexandra , Flowers Brenna , Cooper David A. , Nguyen V. T. , Martinez Millie C. , Mon K. S. , Bosland M. , Zak D. , Runde A. , Sharifi M. N. , Kastrati I. , Minh David , Kregel Steven , Fanning Sean W.
Published: June 2024

Resistance to endocrine therapies remains a major clinical hurdle in breast cancer. Mutations to estrogen receptor alpha (ERα) arise after continued therapeutic pressure. Next generation selective estrogen receptor modulators and degraders/downregulators (SERMs and SERDs) show clinical efficacy, but responses are often non-durable. A tyrosine to serine point mutation at position 537 in the ERα ligand binding domain (LBD) is among the most common and most pathogenic alteration in this setting. It enables endocrine therapy resistance by superceding intrinsic structural-energetic gatekeepers of ER hormone-dependence, it enhances metastatic burden by enabling neomorphic ER-dependent transcriptional programs, and it resists SERM and SERD inhibiton by reducing their binding affinities and abilities to antagonize transcriptional coregulator binding. However, a subset of SERMs and SERDs can achieve efficacy by adopting poses that force the mutation to engage in a new interaction that favors the therapeutic receptor antagonist conformation. We previously described a chemically unconventional SERM, T6I-29, that demonstrates significant anti-proliferative activities in Y537S ERα breast cancer cells. Here, we use a comprehensive suite of structural-biochemical, in vitro, and in vivo approaches to better T6I-29’s activities in breast cancer cells harboring Y537S ERα. RNA sequencing in cells treated with T6I-29 reveals a neomorphic downregulation of DKK1, a secreted glycoprotein known to play oncogenic roles in other cancers. Importantly, we find that DKK1 is significantly enriched in ER+ breast cancer plasma compared to healthy controls. This study shows how new SERMs and SERDs can identify new therapeutic pathways in endocrine-resistant ER+ breast cancers.
The Associations between Health Literacy and Self-Rated Health: The Mediating Role of Life Style Using the Structural Equation Modeling Approach
Authors: Bagherinia Mansour , Rezaeian Shahab , Shakiba Ebrahim , Maleki Raheleh , Mazhin Abbas Mohammad Karimi , Darvishigilan Hadi , Janatolmakan Maryam , Karami Badriyeh
Published: June 2024

Background: Self-Rated Health is related to reduction of burden of diseases and health outcomes. Various factors affect Self-Rated Health. This study aimed to investigate the mediating role of lifestyle in the relationship between health literacy and Self-Rated Health.
Methods: In this cross-sectional study 495 people aged 18- 65 were participated in 2023. Health literacy questionnaire by Montazeri et al., healthy lifestyle assessment questionnaire of Eshaghi et al, and Self-rated health (SRH) by a question developed by the World Health Organization were used. Structural equation modeling (SEM) was used. Statistical analysis of data was performed using STATA 14.2 software.
Results: Based on the results, a significant total effect of health literacy on self-rated health (β= -0.005, P= 0.001), was identified. Life style (β = -0.004) had a direct effect on self-rated health (p < 0.005). The result from SEM indicated that health literacy exhibited a direct effect on life style (β = 78). In addition, considering that health literacy and lifestyle have a significant relationship with self-rated health, and there is a significant relationship between lifestyle and health literacy, it can be concluded that lifestyle plays a mediating role in the relationship between the two variables of health literacy and self-rated health.
Conclusion: Considering the mediating role of lifestyle in the relationship between health literacy and self-rated health, to improve self-rated health, in addition to paying attention to the role of health literacy, it is necessary to take effective measures to positively change people's lifestyle.
Watt-class CMOS-compatible optical high power amplifier
Authors: Singh Neetesh , Lorenzen Jan , Wang Kai , Gaafar Mahmoud , Sinobad Milan , Francis Henry , Edelmann Marvin , Geiselmann Michael , Herr Tobias , Garcia-Blanco Sonia , Kärtner Franz
Published: June 2024

High power amplifiers are critical components in optical systems spanning from long range optical sensing and optical communication systems to micromachining and medical surgery. Today, integrated photonics with its promise of large reductions in size, weight and cost cannot be used in these applications, due to the lack of on-chip high power amplifiers. Integrated devices severely lack in output power due to their small size which limits energy storage capacity. For the last two decades, large mode area (LMA) technology has played a disruptive role in fiber amplifiers enabling a dramatic increase of output power and energy by orders of magnitude. Thanks to the capability of LMA fiber to support significantly larger optical modes the energy storage and power handling capability has significantly increased. Therefore, an LMA device on an integrated platform can play a similar role in power and energy scaling of integrated devices. In this work, we demonstrate LMA waveguide-based CMOS compatible watt-class high power amplifiers with an on-chip output power reaching beyond ~ 1 W within a footprint of only ~ 4 mm2. The power achieved is comparable and even surpasses many fiber-based amplifiers. We believe this work has the potential to radically change the integrated photonics application landscape, allowing power levels previously unimaginable from an integrated device replacing much of today’s benchtop systems. Moreover, mass producibility, reduced size, weight and cost will enable yet unforeseen applications for laser technology.
STUDY OF VAGINAL FLORA AND ITS RELATIONSHIP WITH PRETERM LABOUR PAIN AND PPROM
Authors:   Associate Professor., Mangtani Kratika , Meena Santosh ,   Associate Professor.
Published: June 2024

Objective: The aim of this study is to describe the bacterial flora of women in preterm labor with or without premature rupture of membranes. Methods: Prospective studies of 200 patients with preterm labor were performed. Results: 32 of 200 patients with preterm labor (16%) had bacterial vaginosis. 76 of the 200 patients with preterm labor (38 %) developed premature rupture of the membranes (preterm PROM). Of the 76 patients with preterm PROM, 14 (18.4%) had bacterial vaginosis. Therefore, 14 of the 32 patients with bacterial vaginosis (43.75%) developed preterm PROM. An increased number of organisms detected from the vaginal discharge in patients with preterm labor was associated with preterm PROM. An increased number of organisms detected from the vaginal discharge in patients with preterm labor complicated with bacterial vaginosis was significantly associated with preterm PROM. Conclusions: In preterm labor, the number of different species detected in the vagina provide sensitive and specific prediction of preterm PROM in patients with preterm labor.
CLINICAL STUDY TO CORRELATE THE COMPLICATIONS OF MALARIA WITH PARASITE LOAD AND C - REACTIVE PROTEIN AT THE TIME OF PRESENTATION
Authors: Gupta Priya , Tungikar Sudhir
Published: June 2024

Introduction: Malaria, an important tropical parasitic disease with respect to annual mortality all over the world is becoming an important research area. About 300-500 million cases are being reported every year across the globe, killing one million people per year. 77% of the burden of malaria in south east Asia is from India . Development of complications, leads to severe malaria, that has higher mortality and morbidity. Due to rapid multiplication, the parasite count may rise up to 20-fold over a span of 48 hours without treatment. Patients with high parasite load have a complicated course. This study aim was to correlate complications of malaria with parasite load and C-Reactive Protein (CRP) value at the time of presentation. Materials And Methods: This is a hospital based, cross sectional study done in DR Balasaheb Vikhe Patil Rural Medical College, Loni, Maharsthra, which included 100 consecutive cases of malaria diagnosed through peripheral smear. Patients above 18 years of age without prior co-morbidities were included. Aims and Objectives: To study the Correlation between the Complications of Malaria with Parasite Load and C - Reactive Protein at the Time of Presentation. Results: A total of 100 patients with malaria who satisfied the inclusion criteria were enrolled of which 84 were male and 16 were female. Most of them were between age group 21-40 years. Of total 100 cases, 72 were vivax malaria, 18 were falciparum malaria and 10 were mixed malaria positive. Complications were seen in 32 cases , of which 17 had vivax, 9 had falciparum and 6 had mixed malaria. -25 patients had higyh CRP (>100mg/dl). -86 Patients had low parasitemia (<5%) and 14 patients had high parasitemia (>5%). Patients were divided into two groups of high parasitemia (>5%) and low parasitemia (<5%) Conclusion: Complications of malaria show a positive correlation with high parasite load and high CRP values. Monitoring of treatment and response to anti malaria therapy can be done using parasite load and CRP values. Based on our study vivax malaria can no longer be considered as uncomplicated.
FORMULATION OF A MODE I CRACK PROPAGATION MODEL BY ANALYZING THE STRESS FIELD AT THE CRACK TIP
Authors:   Jean Lorougnon Guede University, Earth Sciences Department, Faculty of Environment, Daloa, Ivory Coast., Doumbia Ahmed , Seri Seri Chardin ,   Felix Houphouet-Boigny University, Physics, Electronic and Telecommunication System Department, Faculty of Sciences of structures of Materials and Technology, Abidjan, IvoryCoast., Traore Seydou ,   Felix Houphouet-Boigny University, Physics, Electronic and Telecommunication System Department, Faculty of Sciences of structures of Materials and Technology, Abidjan, IvoryCoast.
Published: June 2024

One of the phases in the development of materials is knowledge of their possible degradation. At this stage, taking into account the influence of temperature variation remains essential for certain materials. The objective of this work is to take this aspect into account by formulating a mode I crack propagation model by studying the stress field in the vicinity of the crack tip. To do this, starting from Hookes law generalized in linear elasticity, we use the asymptotic expressions in displacements of the crack tip of Moes et Al. in order to obtain the stress field model. To validate the model, a comparison is made with data from the literature. The observations show a very high agreement of results. The advantage of this model is to take into account the role of temperature in the degradation of materials by analyzing crack propagation. It will be used in our future work.
O PAPEL INFORMATIVO DO GRIÔ NOS EQUIPAMENTOS INFORMACIONAIS DA REGIÃO NORDESTE DO BRASIL
Authors: Costa Júlia Raquel Farias da , Albuquerque Daniela Eugênia Moura de
Published: June 2024

The colonial structures that have determined Brazilian society's knowledge references are linked to power relations that privilege the written tradition in information systems. When the priority of these spaces is not to safeguard oral traditions, the griôs, Brazilian traditionalists, fulfill this social role for their community. With this in mind, the aim of this research is to identify how information systems in the Northeast of Brazil are relating to the griôs of their region. It is an exploratory, descriptive and bibliographic study, with a quantitative approach, made up of twelve information centers in the Northeast of Brazil, and the data was collected using questionnaires. The results showed that a considerable proportion of the respondents have a relationship with the oral traditions of the traditional peoples of their region, that they use them as sources of information and that they manifest them in different ways within their facilities, the main one being in storytelling. He also told us that half of the information facilities have measures in place to preserve the oral traditions of the griôs in their region, the main ones being dance performances with the griôs, conversation circles, musical performances, storytelling and workshops. The conclusion is that oral traditions are manifesting themselves in the information facilities of the Brazilian Northeast as sources of information, that the presence of griôs mediating information in these places is a reality and that measures for the preservation of the Griô oral tradition is an emerging responsibility for information facilities.
POLÍTICAS DE INOVAÇÃO DAS ICTS PARAENSES
Authors: Felix Júnior Romero Carrilho , Lima Celson Pantoja , Pinheiro Antônio do Socorro Ferreira
Published: June 2024

Innovation Policies must focus on the organization and management of the processes that guide the transfer of technology and the generation of innovation in the productive environment in line with the priorities of the national science, technology and innovation policy. The objective of this article is to analyze the Innovation Policies of Scientific and Technological Institutions (ICTs) that are linked to the Federal Education Network and implemented in the State of Pará, based on current legislation, as well as the guidelines and objectives for their elaboration in compliance provided for by the Ministry of Science, Technology, Innovations and Communications (MCTIC). The research methodology consisted of reviewing the literature on the role of ICTs, Technological Innovation Centers (NITs) and their innovation policies, as well as document analysis of the regulations established within the scope of each ICT analyzed. The results indicate that, in general, ICTs sought to adapt their internal regulations, based on legislative innovations, however, the documents require review and adaptation. Therefore, the present study will contribute to the institutional maturity of NITs.
Self Management and Learning Interests on Nursing Students Level III of STIKes Santa Elisabeth Medan
Authors: Barus Mardiati , Rupang Ernita Rante , Miltri Januarti Munthe
Published: June 2024

The declining academic quality has been attributed to a waning interest in learning. To address this, effective self-management strategies are crucial. Self-management involves organizing tasks, managing time, making choices, pursuing interests, and preparing mentally and physically. This study examined the relationship between students' self-management abilities and learning preferences in the Level III Nursing program at STIKES Santa Elisabeth Medan in 2023. The study used descriptive analysis with a cross-sectional approach and employed univariate and bivariate analyses, including the Chi-Square test. Results showed that 78.7% of students demonstrated good self-management abilities, while 62.8% displayed an interest in learning. The Chi-Square test indicated no significant relationship (p = 0.816) between students' autonomy and their learning interest in the Level III nursing program at STIKES Santa Elisabeth Medan. In conclusion, the research findings indicate no significant correlation between self-management and learning interests among Santa Elisabeth Medan Ners STIKES students in 2023.
Development of problem and project-based learning syntax to improve vocational student learning outcomes
Authors: Akhyar Muhammad , Ihsan Fatihul , Suharno Suharno , Tamrin AG , Purwanto Purwanto
Published: June 2024

This study aims to: 1) Determine the needs of teachers and students for the development of learning models they face to overcome problems, 2) Formulate the feasibility of problem-based learning syntax, 3) Formulate the feasibility of Project-Based learning syntax, 4) Analyze the feasibility of problem-based learning model syntax and project-based learning in basic electricity and electronics at SMK Negeri 2 Sukoharjo. This study uses a research and development approach. The population in this study were all class X students of the Electronics Department at SMK Negeri 2 Sukoharjo for the 2020/2021 academic year with a sample of 64 students. Data collection techniques are using tests and non-tests. Data analysis used two-way analysis of variance (ANAVA). The results of the study show 1) The results of the analysis of the needs of teachers and students include: a) The results of the analysis of learning evaluations that are always demanded to be better; b) The results of teacher assessment analysis, so that teachers have many choices of learning variations and can make innovations in learning; c) Strategies obtained from data analysis, with details of operational programs as well as guidelines for implementing the strategic plan, duties and roles of the parties involved in the strategic plan, as well as evaluation and monitoring guidelines. 2) The syntax of the problem-based learning model goes through four phases: problem presentation, problem investigation, problem resolution and procedure evaluation. 3) The project-based learning model syntax includes: project startup, solution design, solution development, and presentation. 4) The results of the Wilcoxon test analysis, both problem-based learning and project-based learning, show that there is a difference in scores before and after being given treatment. So, it can be stated that problem-based learning methods and project-based learning are feasible to be used in improving student learning outcomes.
Improving basic technology students’ achievement using differentiated instruction learning strategy among junior secondary school
Authors: Olabiyi Oladiran Stephen
Published: June 2024

This study investigated the improvement of basic technology students' achievement using differentiated instruction learning strategies in Nigerian junior secondary schools using a pre-test and post-test non-equivalent control group quasi-experimental design. The study was guided by three null hypotheses and three research questions, with the experimental group receiving tutelage using the differentiated learning strategy and the control group receiving instruction using the conventional teaching method for eight weeks. The Basic Technology Achievement Test (BTAT), with a KR-20 reliability coefficient of 0.85, was used to collect data. The findings revealed that students in the experimental group performed significantly better in basic technology than students in the control group. Furthermore, male students outperformed their female counterparts in basic technology with a differentiated learning strategy, though there was no significant difference between genders taught basic technology with a differentiated learning strategy. Gender had no statistically significant impact on students' achievement in woodworking technology. Furthermore, the interaction effect of treatment and gender on students' basic technology achievement was not statistically significant. The differentiated learning strategy made lessons more interesting and simpler, and it helped students form friendships. It was thus suggested that differentiated learning strategies be used as a close substitute for traditional teaching methods in teaching basic technology in Nigerian junior secondary schools.
Development of a new concept and definition of inheritance risk management in family businesses toward sustainability
Authors:   Graduate School of Business, Universiti Sains Malaysia (USM), George Town, Malaysia, Al Obaidy Abdulbasit Lutfy A. , Alshehadeh Abdul Razzak ,   Faculty of Business, Al-Zaytoonah University of Jordan, Amman, Jordan, Al-Khawaja Haneen A. ,   Department of Financial Technology and Banking, Faculty of Business, Ajloun National University, Ajloun, Jordan,   Applied Science Research Center, Applied Science Private University, Amman, Jordan,   Swiss FinTech Innovation Lab, University of Zurich, Zurich, Switzerland, Basheti Iman Amin ,   Pharmaceutical Sciences Department, Faculty of Pharmacy, Jadara University, Irbid, Jordan,   Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, NSW, Australia, Al-Zaqeba Murad Ali Ahmad ,   Faculty of Economics and Muamalat (FEM), Universiti Sains Islam Malaysia (USIM), Nilai, Malaysia
Published: June 2024

This paper examines how family businesses manage risks when transferring wealth across generations to ensure sustainability. It develops a thorough framework focusing on maintaining family legacies and business continuity. Key challenges identified include managing control, balancing interests, planning succession, preparing future leaders, and maintaining respect for leadership. The study uses a quantitative method to show that managing risks related to the owner's death is crucial. The findings suggest that managing inheritance risks and achieving successful transitions are vital for the sustainability of family businesses. Inheritance Risk Management (IRM) also helps mediate the impact of legacy risk management on sustainability. The paper recommends creating guidelines, launching awareness campaigns, offering specialized courses, and promoting family governance to improve business performance and social responsibility. Additionally, this research contributes to family business studies by enhancing understanding of inheritance risks and setting the stage for ongoing research and best practices development. These strategies aim to equip family businesses to meet current needs and future challenges effectively.
Transport mobility restrictions as a pandemic
response:
a case study Germany (Preprint)
Authors: MHB Hakan
Published: June 2024

BACKGROUND

The COVID19 pandemic has caused a large number of infections and fatalities, causing administrations
at various levels to limit public mobility. This paper analyzes the complex association between the
stringency of restrictions, public mobility, and reproduction rate (R-value) on a national level for Germany.

OBJECTIVE

The goals were to analyze; a) the correlation between government restrictions and public mobility and b)
the association between public mobilities and virus reproduction.

METHODS

In addition to correlations, a Gaussian
Process Regression Technique is used to fit the interaction between mobility and R-value.

RESULTS

The main
findings are that: (i) Government restrictions has a high association with reduced public mobilities,
especially for non-food stores and public transport, (ii) Out of six measured public mobilities, retail,
recreation, and transit station activities have the most significant impact on COVID19 reproduction rates.

CONCLUSIONS

A mobility reduction of 30% is required to have a critical negative impact on case number dynamics,
preventing further spread.
Voices of Pathos and Protest from Dalit Women in Contemporary Indian Society
Authors: Aayushi Aayushi , Jha Dr. Sunil Kumar
Published: June 2024

Majority of the news that are reported on the violation of human rights in contemporary Indian media points towards the insolent and dissolute mind-set of a group of people conquered by caste hierarchy. The victims of this degenerated mentality happen to be the marginalised and oppressed masses in society who have been silent sufferers for centuries. In such a struggle, Dalit women cannot refrain themselves from the revolutionary struggles to attain equality and freedom. Being a social activist, I put forward my thesis in my attempt to join hands with Dalit women in India, who are victims of oppression from within and outside their community. They are prone to physical assaults, verbal assaults, sexual harassment and exploitation, rape, forced prostitution and domestic violence in addition to poverty and hunger. With fiery determination, Dalit women have been fighting with their pen, expressing their brutal experiences and their stiff resistance against the obnoxious caste hierarchy. Poetry being the most striking form of expression brings forth their utmost discontent with the caste system and proclaims their vehement dissent. This thesis is an attempt to analyse the poetry of Dalit women and the propositions of the dialectics of pathos and protest. The study also problematizes Dalit women’s poetry, which as a form of activism and resistance can in fact, bring a change in the lives of the ordinary Dalit women in India.
Synthesizing Dichotomies in Tom Stoppard’s Play Arcadia
Authors: Dhir Dr. Bani Dayal
Published: June 2024

The research paper connects thematic complexities in Tom Stoppard’s play Arcadia (1993) with paradigm shifts in science. A remarkable illustration of science as a metaphor for human behaviour, Arcadia alternates between the early 1800s and 1993, interlinking the scientific pursuits of characters across time periods. Stoppard dexterously introduces Chaos Theory into the play through a young girl, Thomasina Coverly, who intuitively anticipates Fractals in the early nineteenth century. The playwright takes his readers through a world first ruled by Newton’s laws, then one where those laws are revised by the laws of Thermodynamics, and then one where they are revised yet again by Chaos Theory. The paper brings out a series of dichotomies latent in the plot structure of the play - Classicism versus Romanticism, Science versus Humanities and Newtonian Determinism versus the Second Law of Thermodynamics, which signify the presence of order and purpose amid the apparent randomness and disorder in the universe. Arcadia is an apt exemplification of how order arises from chaos.
Unleashing Students’ Leadership and Global Citizenship Skills through ELT for Increased Employability
Authors: Belabcir Souad
Published: June 2024

To meet the demands of a globalized world, English learners need to develop employability skills that qualify them to achieve academic and professional success. The global market is in desperate need of leaders who can surpass all cross-cultural barriers and embrace global citizenship. Employees are required to develop leadership and global citizenship skills so as to enhance their creativity, productivity and sustainability in the workplace. Against this backdrop, English Language Teaching (ELT) seems to be an essential means for empowering students’ leadership and global citizenship skills so as to facilitate their holistic development. To investigate this issue, the current study adopted a quantitative research method using a close-ended questionnaire sent to 58 Moroccan ELT teachers. The data gathered was analyzed through the SPSS (Statistical Package of Social Sciences) in the form of descriptive statistics in order to explore teachers’ perceptions regarding the promotion of leadership and global citizenship in ELT and to suggest effective classroom practices to reach this purpose. The study at hand will contribute to expanding literature on employability skills development in ELT. Furthermore, the implications and recommendations proposed will guide ELT teachers in fostering leadership and global citizenship among English learners.
Usefulness of Fisheries Technical Skills in Fish Business Management: Lessons Learned Through Krishi Vigyan Kendra, South Tripura
Authors: Debnath Biswajit
Published: June 2024

This study aimed at analyzing the practical usefulness of fisheries technical skills acquired by the participants while attending the fisheries training programmes conducted by Krishi Vigyan Kendra, South Tripura during last decade. The entrepreneurs who received training were categorized under three group viz. Farmers, Rural Youths and Farm women. Response regarding usefulness of fisheries technical skills was recorded in five point ordinal scale using telephonic interview and text messaging with randomly selected entrepreneurs. The Kruskal-Wallis non parametric test showed that there was significant difference in at least two groups with respect to the usefulness of fisheries technical skills gained from training during the period under study. We further proceeded for post hoc test through pair wise comparison of average mean ranks of entrepreneurs under all the groups viz. Farmers (Male), Rural Youths and Farm women. It was observed that the usefulness of fisheries technical skills gained from training conducted by KVK, South Tipura was higher for farm women as compared to that of trained farmers and rural youths. The usefulness of fisheries technical skills by farmers and rural youths were also ranked good, but post hoc test and pairwise comparison did not show significant difference between two. Scope exits for KVK, South Tripura to make the skill development programmes more useful by improving training content as well as by creating suitable situation for the trainees to use the acquired skills properly.
تعليم القواعد و تطويره بورقة العمل على أساس المدخل المعرفي لترقية قدرة الطلاب على القواعد
Authors: Azwir Azwir , Ali Basa  , Mukhlisah
Published: June 2024

Based on the challenges students encounter in understanding grammatical and morphological materials, this research aims to enhance the teaching of grammatical rules by using worksheets based on the cognitive approach. This is due to the students' difficulties in grasping the grammatical rules they have learned. The worksheets were developed specifically to address this need. The students' learning conditions were consistently focused on comprehending grammar materials. The research utilized direct observation, questionnaires, expert validation, and testing as tools, and the results obtained indicate that teaching grammar using a worksheet based on the cognitive approach effectively improves students' ability to understand and apply grammatical rules.
Guía orientada para la disminución de posibles fraudes en transacciones de Nfts en Cúcuta
Authors: Fuentes-Castro Karol Dayana , Ruiz-Bernal Samuel , Reyes-Gelvez Jhoan Sebastián
Published: June 2024

El propósito de este artículo es desarrollar una guía para desarrollar una guía orientada para la disminución de posibles fraudes en transacciones de Ntfs en Cúcuta. La elaboración de una guía encaminada a reducir posibles fraudes en transacciones NTFS en Cúcuta es fundamental en el mundo actual, donde las transacciones financieras son cada vez más frecuentes y sofisticadas. Cúcuta, como ciudad en constante crecimiento y desarrollo, se convierte en un marco favorable para diversas actividades empresariales financieras, lo que también significa un mayor riesgo y malas prácticas en este ámbito. La seguridad de las transacciones financieras es esencial para garantizar las operaciones comerciales y la confianza de los consumidores en el sistema financiero.
Controle da dor de discoespondilite em cão com uso de plantas medicinais e laserterapia: relato de caso
Authors:   , Boneto Gabriela Garcia
Published: June 2024

Discoespondilite é uma infecção bacteriana ou fúngica dos discos intervertebrais em cães que provoca dor intensa na coluna. O trabalho aborda o uso de plantas medicinais e laserterapia para o controle da dor da discoespondilite em uma cadela, SRD de 13 anos com histórico de pancreatite, doença renal crônica e hepática. Que após o tratamento convencional, não resultar em melhora clínica do paciente, o tutor adotou terapias complementares com plantas medicinais em forma de infusão e tintura, administrada diariamente e complementadas com laserterapia. A ação da infusão e da tintura combinadas com o laser possibilitou a melhora clínica do animal.
Atendimento odontológico para pacientes com transtorno do espectro autista
Authors:   , Carmo Ana Julia Cleto do , Xavier Laura Fernanda , Silva Lavínia Oliveira , Silva Mariana Munhoz
Published: June 2024

O Transtorno do Espectro Autista (TEA) é uma alteração no neurodesenvolvimento que implica o convívio social, a comunicação e repetição comportamental. Pacientes com essa condição possuem maiores limitações como atraso na fala, comunicação não verbal, alterações no comportamento, deficiência sensorial, limitações motoras e a cavidade bucal deles tende a ser mais susceptível à cárie e outras doenças, em razão disso o atendimento odontológico é um desafio para o cirurgião-dentista, pois é capaz de acionar a hipersensibilidade do paciente e a estimulação sensorial, desencadeando respostas indesejadas durante o tratamento odontológico. Esta revisão tem como objetivo expressar as características clínicas bucais e comportamentais dos pacientes com TEA, discorrer sobre o manejo do cirurgião-dentista no atendimento e no seu entendimento sobre as dificuldades apresentadas por cada paciente individualmente. Os conceitos utilizados através de pesquisas bibliográficas abordam temas de artigos e livros sobre o TEA, o tratamento odontológico e o manejo adequado do cirurgião-dentista frente aos pacientes com TEA. Conclui-se que são necessárias para o atendimento odontológico técnicas de manejo adequadas, para garantir acolhimento ao paciente e um atendimento humanizado, assim ele poderá se sentir seguro para que assim o cirurgião-dentista consiga alcançar melhores resultados no tratamento odontológico.
Expanding the synthetic biology repertoire of a fast-growing cyanobacterium Synechococcus elongatus PCC 11801
Authors: Wangikar Pramod , Madhu Swati , Sengupta Annesha , SARNAIK ADITYA
Published: June 2024

Synechococcus elongatus PCC 11801 is a fast-growing
cyanobacterium, exhibiting high tolerance to environmental stresses. We
have earlier characterized its genome and analysed its transcriptome and
proteome. However, to deploy it as a potential cell factory, it is
necessary to expand its synthetic biology toolbox, including promoter
elements and ribosome binding sites (RBSs). Here, based on the global
transcriptome analysis, 48 native promoters of the genes with high
transcript count were characterized using a fluorescent reporter system.
P , P , P
promoters exhibited consistently higher
fluorescence under all the cultivation conditions. Similarly, from the
genome data and proteome analysis, 534 operons were identified. Fifteen
intergenic regions exhibiting higher protein expression from the
downstream gene were systematically characterized for RBSs, using an
operon construct comprising of fluorescent protein genes eyfp and
mTurq under P (P
: eyfp:RBS: mTurq:T
). Overall, the work presents promoter and
RBS sequence libraries, with varying strengths, to expedite
bioengineering of PCC 11801.
Doxorubicin Downregulates NEAT1 Expression in Breast Cancer
Authors: azizi zahra , Acikbas Ibrahim , Urganci Buket Er , Dogan Cihangir
Published: June 2024

Breast cancer (BC) is the most prevalent cancer among women worldwide
and the major cause of cancer-associated mortalities. Commonly, the
primary treatment used for cancer patients is chemotherapy. Doxorubicin
(DOX) is considered an anthracycline derivative and conversant
chemotherapeutic agent and one of the most influential chemotherapeutic
drugs. In addition, it is among the most frequently applied drugs for
BC. According to recent reports, RNA is crucial for the development of
several cancers and illnesses. Long non-coding RNAs (lncRNAs) exert a
particularly vital role in this respect. The current reviews demonstrate
that lncRNAs can function as oncogenic and tumor suppressor and
contribute to cancer development and progression. Our study addressed
nuclear-enriched abundant transcript 1 (NEAT1) and the effect of DOX
contributing to the regulation of miR410 by NEAT1. After receiving DOX
treatment, it was discovered that NEAT1 expression levels were
practically decreased in human BC cells, including MDA-MB231 and MCF-7.
As expected, further expression than cancer cell lines were detected in
normal mammary epithelial cell MCF-10A. Simultaneously, neither the dose
administration levels nor the cell lines showed any changes in the
expression of miR410. Alterations in the expression level were measured
by the quantitative real-time polymerase chain reaction analyzes. This
indicates that DOX may affect BC lines via NEAT1, and miR410 is
ineffective in this pathway. Our data confirmed that the contribution of
NEAT1 in DOX treatment. Accordingly, it can be provided as a biomarker
in the diagnosis and treatment of BC.
EFFECTS OF N-HEXANE FRACTION OF THE SEED EXTRACT OF Piper guineense ON N ω -NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE – INDUCED HYPERTENSION IN RATS
Authors: Olopade Elijah Oluwatosin , Morakinyo Adetoun Elizabeth , Alao Jude Oluwapelumi , Oyedepo Temitope A.
Published: June 2024

Aim of the Study This study aimed to investigate the effects of
the n-hexane fraction of the ethanolic seed extract of PG (NFESEPG) on
hypertension induced by Nω-nitro-L-arginine methyl ester (L-NAME) in
rats. Specifically, the study examined the impact of NFESEPG on blood
pressure, oxidative stress markers, NO concentration,
angiotensin-converting enzyme (ACE) and arginase activities, and cardiac
biomarkers in hypertensive rats. Materials and Methods The
study involved collecting, identifying, and processing the PG plant to
obtain the ethanolic seed extract. The extract was then partitioned with
solvents to isolate the n-hexane fraction. Hypertension was induced in
rats by oral administration of L-NAME for ten days, while concurrent
treatment with NFESEPG at two doses (200 and 400 mg/kg/day) was
administered orally. Blood pressure was measured using a non-invasive
tail-cuff method, and various biochemical parameters were assessed.
Results Treatment with both doses of NFESEPG significantly
reduced systolic and diastolic blood pressure in L-NAME-induced
hypertensive rats. Additionally, NFESEPG administration increased NO
concentration and decreased ACE and arginase activities, malondialdehyde
(MDA) levels, and cardiac biomarkers in hypertensive rats.
Conclusions The findings indicate that NFESEPG effectively
lowered blood pressure in hypertensive rats induced by L-NAME,
potentially through mechanisms involving the modulation of oxidative
stress, NO bioavailability, and cardiac biomarkers. These results
suggest the therapeutic potential of NFESEPG in managing hypertension
and related cardiovascular complications.
Topological Distributed Multi-rate Output Feedback Exponential Sliding Mode Consensus Protocol for Discrete Multi-Agent System
Authors: Joshi Nikita , Mehta Axaykumar
Published: June 2024

This paper presents a novel Topological Distributed Multi-Rate State
Estimator (TDMRSE) for designing a Distributed Output Feedback
Exponential Sliding Mode Consensus (DOFESMC) protocol for a Discrete
Multi-Agent System (DMAS) to achieve the leader-follower consensus.
First, a topological distributed multi-rate state estimator is proposed
for a DMAS using the graph theory where the stack of output at each
agent is measured at a faster sampling rate than the input in DMAS.
Then, the estimated state variables of each agent are used to design the
DOFESMC protocol for DMAS to achieve the consensus by ensuring the
minimal consensus effort, the minimum time for achieving the consensus,
and the deviation of agents from the consensus of the order O(T^3).
The condition for global consensus stability of DMAS with the proposed
DOFESMC protocol is derived using the Lyapunov theory. The proposed
DOFESMC protocol is validated in simulation and experiment on a DMAS
comprised of 2-Degree of Freedom (DOF) robotic arms connected in a given
communication topology. Moreover, the proposed protocol is compared with
the protocol designed using a distributed Luenberger observer for
consensus performance in terms of Integrated Square Error, control
effort for consensus, and deviation from consensus. It is inferred from
the simulation and experimental results that the proposed DOFESMC
protocol with TDMRSE outperforms the protocol designed with a
distributed Luenberger observer.
Remarkable CO2 Photocatalytic Reduction Enabled by UiO-66-NH2 Anchored on Flower-like ZnIn2S4
Authors: Guo Shaohong , Yu Huimin , jia meilin , Jia Jingchun , Chang Ying , Wang Jiang
Published: June 2024

Abstract: The utilization of renewable solar energy for the
photocatalytic transformation of carbon dioxide (CO2) into valuable
chemical substances is considered an optimal strategy to simultaneously
address climate challenges and tackle energy scarcity. Herein, we
prepared heterojunction photocatalysts UiO-66-NH2/ZnIn2S4, which were
successfully applied in the photocatalytic reduction of CO2. The yield
of the main product CO, for the optimal UiO-66-NH2/ZnIn2S4-2 sample
could reach up to 57 μmol g-1 h-1 when converting CO2 under the visible
light irradiation, which was approximately 3.35 and 2.71 times higher
than that achieved by the individual UiO-66-NH2 and ZnIn2S4 samples,
respectively. The better photocatalytic performance of the
UiO-66-NH2/ZnIn2S4-2 composites can be attributed to its synergistic
effect resulting from tight interfacial contacts, special charge
transfer pathways and excellent CO2 adsorption capacity. Furthermore,
the intimate contact between UiO-66-NH2 and flower-like ZnIn2S4
accelerates electron transmission while effectively suppressing the
quenching of photogenerated carriers. This research provides vital
knowledge for the rational design of heterostructures aimed at enhancing
the efficiency of CO2 photocatalysis for solar fuel production.
Plant growth suppression by an allelopathic N-trans-cinnamoyltyramine to some invasive weeds and weedy rice in tropical and temperate regions.
Authors: Le Vang , Nguyen Ay , Luu Danh , Fritschi Felix , Nguyen Cuong , Ho Thi
Published: June 2024

N-trans-cinnamoyltyramine (NTCT) has been identified from an
allelopathic Vietnamese rice accession OM 5930. The study employed a
rigorous analysis of NTCT’s effects on shoot and root growth across
multiple plant species. Notably, barnyardgrass and red sprangletop
exhibited significant reductions in shoot and root growth with
increasing NTCT concentrations, indicating a dose-dependent response
(from 0.024 μM to 24 μM). Weedy rice accessions PI 653426 and PI 653431
also display dose-dependent effects, with notable declines in both shoot
and root growth (from 0.25 μM to 15.6 μM and from 0.44 μM to 85.8 μM,
respectively). Additionally, NTCT demonstrates potent inhibitory effects
on palmer amaranth, timothy, canola, cress, and lettuce, with increasing
concentrations leading to substantial reductions in growth across all
species (Average from 2.4 μM). Linear regression analysis reveals the
ED50 values for NTCT, providing critical insights into the concentration
required for 50% growth inhibition in each species. These values range
from 0.19 to 166.1 μM for shoots and from 1.74 to 33.07 μM for roots,
highlighting the varying sensitivities among the test plant species. The
findings underscore NTCT’s efficacy in suppressing the growth of a wide
range of weeds, including both grasses and broadleaf species. The
compound shows promise for sustainable weed management practices,
particularly in addressing herbicide-resistant weeds in diverse
ecological settings. By elucidating NTCT’s inhibitory and
species-specific responses, this study contributes valuable insights to
the development of eco-friendly herbicidal agents for effective weed
control