bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Differing Durations of High-Intensity Intermittent Activity on Cognitive Function in Adolescents
Authors: Hatch Lorna M. , Dring Karah J. , Williams Ryan A. , Sunderland Caroline , Nevill Mary E. , Cooper Simon B.
Published: November 2021

Exercise duration may influence the acute effects on cognition. However, only one study to date has explored the dose-response relationship between exercise duration and cognition in adolescents. Thus, the purpose of this study was to investigate the effect of differing durations of high-intensity intermittent running on cognition in adolescents. Thirty-eight adolescents (23 girls) completed three trials separated by 7 d: 30 min exercise, 60 min exercise, and rest; in a randomised crossover design. The exercise was a modified version of the Loughborough Intermittent Shuttle Test (LIST), which elicited high-intensity intermittent exercise. Cognitive function tests (Stroop test, Sternberg paradigm, Flanker task) were completed 30 min pre, immediately post, and 45 min post exercise. Response times on the incongruent level of the Flanker task improved to a greater extent 45 min following the 30 min LIST, compared to rest (p = 0.009). Moreover, response times improved to a greater extent on the three-item level of Sternberg paradigm 45 min following the 30 min LIST, compared to the 60 min LIST (p = 0.002) and rest (p = 0.013), as well as on the five-item level 45 min following the 30 min LIST, compared to the 60 min LIST (p = 0.002). In conclusion, acute exercise enhanced subsequent cognition in adolescents, but overall, 30 min of high-intensity intermittent running is more favourable to adolescents’ cognition, compared to 60 min.
The Cost Effectiveness of Ecotherapy as a Healthcare Intervention, Separating the Wood from the Trees
Authors: Hinde Sebastian , Bojke Laura , Coventry Peter
Published: November 2021

Internationally, shifts to more urbanised populations, and resultant reductions in engagements with nature, have been a contributing factor to the mental health crisis facing many developed and developing countries. While the COVID-19 pandemic reinforced recent trends in many countries to give access to green spaces more weight in political decision making, nature-based activities as a form of intervention for those with mental health problems constitute a very small part of patient pathways of care. Nature-based interventions, such as ecotherapy, are increasingly used as therapeutic solutions for people with common mental health problems. However, there is little data about the potential costs and benefits of ecotherapy, making it difficult to offer robust assessments of its cost-effectiveness. This paper explores the capacity for ecotherapy to be cost-effective as a healthcare intervention. Using a pragmatic scoping review of the literature to understand where the potential costs and health benefit lie, we applied value of information methodology to identify what research is needed to inform future cost-effectiveness assessments. We show that there is the potential for ecotherapy for people with mild to moderate common mental health problems to be cost-effective but significant further research is required. Furthermore, nature-based interventions such as ecotherapy also confer potential social and wider returns on investment, strengthening the case for further research to better inform robust commissioning.
Effects of Mobile Application Program (App)-Assisted Health Education on Preventive Behaviors and Cancer Literacy among Women with Cervical Intraepithelial Neoplasia
Authors: Lee Yi-Hui , Huang Lian-Hua , Chen Su-Hui , Shao Jung-Hua , Lai Chyong-Huey , Yang Nan-Ping
Published: November 2021

Objective: This study aimed (1) to study the effects of health education on preventive behaviors and cancer literacy among women with cervical intraepithelial neoplasia (CIN); (2) to compare the effects of mobile application program (App)-assisted health education with traditional book-form health education. Participants: A total of 132 women ages 20 to 69 years women. Methods: This prospective longitudinal study enrolled 132 CIN women who were evaluated three times. Propensity score matching was used by controlling subjects’ age strata, body mass index, education level, occupation, and type of surgery. Results: The influences of various educational tools were investigated. Four domains were assessed, including health behavior, attitude towards behavior change, self-efficacy of behavior, and cervical cancer (CCa) literacy. Significant improvements in behavior change and CCa literacy due to a health education program were observed (p ≤ 0.002). The App combined with a traditional booklet had the highest score for behavior change and was significantly greater than the booklet-only learning (p = 0.002). The App-assisted form, either App alone or combined with booklet, had a significantly better impact on health promotion when compared to the booklet alone (p = 0.045 and 0.005, respectively). App-only learning had the highest score of CCa literacy (p = 0.004). Conclusion: Health education interventions can have positive effects in terms of change of behavior and CCa literacy. App-assisted learning could be used as a supportive technology, and App learning alone or combined with a traditional booklet may be an innovative model of clinical health promotion for women with CIN.
Ecological Risk Assessment and Protection Zone Identification for Linear Cultural Heritage: A Case Study of the Ming Great Wall
Authors: Li Li , Feng Rundong , Xi Jianchao
Published: November 2021

Ecological risk assessment is an important part of the sustainable development of World Heritage. The Ming Great Wall Heritage (MGWH) plays an important role in World Heritage conservation as a representative of large linear heritage, yet its ecological risks have not received much attention. This study assessed the ecological risk of MGWH based on simultaneous consideration of spatial heterogeneity and autocorrelation of geographic factors, and four protection zones were further identified from the perspective of preservation status and risk by using GeoDetector, principal component analysis and bivariate autocorrelation. The results showed that there were statistically significant differences in the preservation status of MGWH at different elevations. Based on this assessed ecological risk, it was found that 63.49% of MGWH grids were in the low to medium risk, while the highest risk areas (16.61%) were mainly concentrated in lower (200–500 m) and medium (500–1000 m) elevation. As elevation increased, the dominant factor of ecological risk shifted from human factors to natural factors and the main ecological risk showed a trend of increasing and then decreasing with increasing elevation. In addition, four types of risk protection zones (i.e., Protection—Restricted, Restoration—Moderate exploited, Restoration—Restricted and Protection—Moderate exploited) and policy suggestions were identified in this study from the perspectives of conservation, restoration and development, respectively. Future ecological protection of the MGWH should be based on the principle of “cultural heritage protection first”, with restricted development and use (e.g., tourism and education) and enhanced ecological restoration and environmental management of the surrounding area. This study provides references for the risk assessment of the cultural heritage at a large spatial scale, which is conducive to the maintenance and improvement of heritage value.
Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds
Authors: Di Porzio Anna , Galli Ubaldina , Amato Jussara , Zizza Pasquale , Iachettini Sara , Iaccarino Nunzia , Marzano Simona , Santoro Federica , Brancaccio Diego , Carotenuto Alfonso , De Tito Stefano , Biroccio Annamaria , Pagano Bruno , Tron Gian Cesare , Randazzo Antonio
Published: November 2021

Besides the well-known double-helical conformation, DNA is capable of folding into various noncanonical arrangements, such as G-quadruplexes (G4s) and i-motifs (iMs), whose occurrence in gene promoters, replication origins, and telomeres highlights the breadth of biological processes that they might regulate. Particularly, previous studies have reported that G4 and iM structures may play different roles in controlling gene transcription. Anyway, molecular tools able to simultaneously stabilize/destabilize those structures are still needed to shed light on what happens at the biological level. Herein, a multicomponent reaction and a click chemistry functionalization were combined to generate a set of 31 bis-triazolyl-pyridine derivatives which were initially screened by circular dichroism for their ability to interact with different G4 and/or iM DNAs and to affect the thermal stability of these structures. All the compounds were then clustered through multivariate data analysis, based on such capability. The most promising compounds were subjected to a further biophysical and biological characterization, leading to the identification of two molecules simultaneously able to stabilize G4s and destabilize iMs, both in vitro and in living cells.
The Presence of Yin-Yang Effects in the Migration Pattern of Staurosporine-Treated Single versus Collective Breast Carcinoma Cells
Authors: Meyer Frank A. H. , Kraus Dominik , Glassmann Alexander , Veit Nadine , Winter Jochen , Probstmeier Rainer
Published: November 2021

Background: Staurosporine-dependent single and collective cell migration patterns of breast carcinoma cells MDA-MB-231, MCF-7, and SK-BR-3 were analysed to characterise the presence of drug-dependent migration promoting and inhibiting yin-yang effects. Methods: Migration patterns of various breast cancer cells after staurosporine treatment were investigated using Western blot, cell toxicity assays, single and collective cell migration assays, and video time-lapse. Statistical analyses were performed with Kruskal–Wallis and Fligner–Killeen tests. Results: Application of staurosporine induced the migration of single MCF-7 cells but inhibited collective cell migration. With the exception of low-density SK-BR-3 cells, staurosporine induced the generation of immobile flattened giant cells. Video time-lapse analysis revealed that within the borderline of cell collectives, staurosporine reduced the velocity of individual MDA-MB-231 and SK-BR-3, but not of MCF-7 cells. In individual MCF-7 cells, mainly the directionality of migration became disturbed, which led to an increased migration rate parallel to the borderline, and hereby to an inhibition of the migration of the cell collective as a total. Moreover, the application of staurosporine led to a transient activation of ERK1/2 in all cell lines. Conclusion: Dependent on the context (single versus collective cells), a drug may induce opposite effects in the same cell line.
Proper Balance of Small GTPase rab10 Is Critical for PGC Migration in Zebrafish
Authors: Mo Chengyu , Li Wenjing , Jia Kuntong , Liu Wei , Yi Meisheng
Published: November 2021

MicroRNAs (miRNAs) play important roles in post-transcriptional repression in nearly every biological process including germ cell development. Previously, we have identified a zebrafish germ plasm-specific miRNA miR-202-5p, which regulates PGC migration through targeting cdc42se1 to protect cdc42 expression. However, knockdown of cdc42se1 could not significantly rescue PGC migration in maternal miR-202 mutant (MmiR-202) embryos, indicating that there are other target genes of miR-202-5p required for the regulation of PGC migration. Herein, we revealed the transcriptional profiles of wild type and MmiR-202 PGCs and obtained 129 differentially expressed genes (DEGs), of which 42 DEGs were enriched cell migration-related signaling pathways. From these DEGs, we identified two novel miR-202-5p target genes prdm12b and rab10. Furthermore, we found that disruption of rab10 expression led to significantly migratory defects of PGC by overexpression of rab10 siRNA, or WT, inactive as well as active forms of rab10 mRNA, and WT rab10 overexpression mediated migratory defects could be partially but significantly rescued by overexpression of miR-202-5p, demonstrating that rab10 is an important factor involved miR-202-5p mediated regulation of PGC migration. Taken together, the present results provide significant information for understanding the molecular mechanism by which miR-202-5p regulates PGC migration in zebrafish.
Investigating the Recycling Potential of Glass Based Dye-Sensitized Solar Cells—Melting Experiment
Authors: Schoden Fabian , Schnatmann Anna Katharina , Davies Emma , Diederich Dirk , Storck Jan Lukas , Knefelkamp Dörthe , Blachowicz Tomasz , Schwenzfeier-Hellkamp Eva
Published: November 2021

The effects of climate change are becoming increasingly clear, and the urgency of solving the energy and resource crisis has been recognized by politicians and society. One of the most important solutions is sustainable energy technologies. The problem with the state of the art, however, is that production is energy-intensive and non-recyclable waste remains after the useful life. For monocrystalline photovoltaics, for example, there are recycling processes for glass and aluminum, but these must rather be described as downcycling. The semiconductor material is not recycled at all. Another promising technology for sustainable energy generation is dye-sensitized solar cells (DSSCs). Although efficiency and long-term stability still need to be improved, the technology has high potential to complement the state of the art. DSSCs have comparatively low production costs and can be manufactured without toxic components. In this work, we present the world’ s first experiment to test the recycling potential of non-toxic glass-based DSSCs in a melting test. The glass constituents were analyzed by optical emission spectrometry with inductively coupled plasma (ICP-OES), and the surface was examined by scanning electron microscopy energy dispersive X-ray (SEM-EDX). The glass was melted in a furnace and compared to a standard glass recycling process. The results show that the described DSSCs are suitable for glass recycling and thus can potentially circulate in a circular economy without a downcycling process. However, material properties such as chemical resistance, transparency or viscosity are not investigated in this work and need further research.
The Influence of Sandblasting Process Parameters of Aerospace Aluminium Alloy Sheets on Adhesive Joints Strength
Authors: Miturska-Barańska Izabela , Rudawska Anna , Doluk Elżbieta
Published: November 2021

In this study, the influence of sandblasting process parameters as a surface preparation method on the strength of single-lap adhesive joints of EN AW 2024 T3 aerospace aluminium alloy sheets was determined. Eleven sets of sandblasting parameters were used, which were determined according to a determined experimental plan. The variable factors in the sandblasting process were pressure, nozzle distance, and workpiece displacement speed. The sand jet incidence angle was constant. Garnet 80 E+ was the abrasive material that was used. The joints were made using an epoxy adhesive composition of Epidian 5 epoxy resin and a PAC curing agent. The influence of the surface preparation method on the surface roughness and contact angle to determine the surface free energy was evaluated. The shear strength of the adhesive joints was also determined, which finally allowed the evaluation of the applied surface treatment variants. The obtained results were subjected to statistical analysis, which indicated that the highest shear strength of the adhesive joints was obtained for samples whose surfaces were treated by sandblasting at parameter configurations in which the pressure was 5–6 × 105 Pa; the distance between the nozzle and the sandblasted surface should not be greater than 97 mm, and the speed at which the workpiece moves in relation to the nozzle should not be greater than 75 mm/min.
Interlayer Strength of 3D-Printed Mortar Reinforced by Postinstalled Reinforcement
Authors: Park Jihun , Bui Quang-The , Lee Jungwoo , Joh Changbin , Yang In-Hwan
Published: November 2021

This work was designed to evaluate the interlayer strength of 3D-printed mortar with postinstalled interlayer reinforcement. Two methods of postinstalled interlayer reinforcement were considered according to the amount of overlapping. The first method did not include overlapping of the interlayer reinforcement, while the second method included overlap lengths of 20 and 40 mm. Additionally, two different curing conditions were considered: air-curing conditions and water-curing conditions. The compressive, splitting tensile, and flexural tensile strengths of 3D-printed mortar specimens with different reinforcement methods and curing conditions were investigated under three loading directions. The three loading directions were defined based on the three planes of the printed specimens. The compressive, splitting tensile, and flexural tensile strengths were dependent on the loading directions. In particular, the splitting and flexural tensile strengths decreased considerably when tensile stresses acted on the interlayers of the 3D-printed mortar specimens. However, when longitudinal interlayer reinforcement penetrated the printed layers, the flexural tensile strength or interlayer bonding strength of the printed specimens increased significantly at the interlayers. In addition, mortar specimens reinforced with overlap lengths of 20 and 40 mm were investigated in this study. The flexural tensile strength or interlayer bonding strength of 3D-printed mortar decreased after treatment under air-curing conditions because the interlayers of the printed mortar formed more pores under these conditions and were more vulnerable under loading. Finally, the findings of this study suggested that interlayer reinforcement is a potential method for improving the interlayer bonding strength of 3D-printed mortar.
Proper Generalized Decomposition for Parametric Study and Material Distribution Design of Multi-Directional Functionally Graded Plates Based on 3D Elasticity Solution
Authors: Kazemzadeh-Parsi Mohammad-Javad , Chinesta Francisco , Ammar Amine
Published: November 2021

The use of mesh-based numerical methods for a 3D elasticity solution of thick plates involves high computational costs. This particularly limits parametric studies and material distribution design problems because they need a large number of independent simulations to evaluate the effects of material distribution and optimization. In this context, in the current work, the Proper Generalized Decomposition (PGD) technique is adopted to overcome this difficulty and solve the 3D elasticity problems in a high-dimensional parametric space. PGD is an a priori model order reduction technique that reduces the solution of 3D partial differential equations into a set of 1D ordinary differential equations, which can be solved easily. Moreover, PGD makes it possible to perform parametric solutions in a unified and efficient manner. In the present work, some examples of a parametric elasticity solution and material distribution design of multi-directional FGM composite thick plates are presented after some validation case studies to show the applicability of PGD in such problems.
Transmission of Escherichia coli from Manure to Root Zones of Field-Grown Lettuce and Leek Plants
Authors: van Overbeek Leo , Duhamel Marie , Aanstoot Stefan , van der Plas Carin Lombaers , Nijhuis Els , Poleij Leo , Russ Lina , van der Zouwen Patricia , Andreo-Jimenez Beatriz
Published: November 2021

Pathogenic Escherichia coli strains are responsible for food-borne disease outbreaks upon consumption of fresh vegetables and fruits. The aim of this study was to establish the transmission route of E. coli strain 0611, as proxy for human pathogenic E. coli, via manure, soil and plant root zones to the above-soil plant compartments. The ecological behavior of the introduced strain was established by making use of a combination of cultivation-based and molecular targeted and untargeted approaches. Strain 0611 CFUs and specific molecular targets were detected in the root zones of lettuce and leek plants, even up to 272 days after planting in the case of leek plants. However, no strain 0611 colonies were detected in leek leaves, and only in one occasion a single colony was found in lettuce leaves. Therefore, it was concluded that transmission of E. coli via manure is not the principal contamination route to the edible parts of both plant species grown under field conditions in this study. Strain 0611 was shown to accumulate in root zones of both species and metagenomic reads of this strain were retrieved from the lettuce rhizosphere soil metagenome library at a level of Log 4.11 CFU per g dry soil.
Towards Unravelling the Role of ERα-Targeting miRNAs in the Exosome-Mediated Transferring of the Hormone Resistance
Authors: Andreeva Olga E. , Sorokin Danila V. , Mikhaevich Ekaterina I. , Bure Irina V. , Shchegolev Yuri Y. , Nemtsova Marina V. , Gudkova Margarita V. , Scherbakov Alexander M. , Krasil’nikov Mikhail A.
Published: November 2021

Hormone therapy is one of the most effective breast cancer treatments, however, its application is limited by the progression of hormonal resistance, both primary or acquired. The development of hormonal resistance is caused either by an irreversible block of hormonal signalling (suppression of the activity or synthesis of hormone receptors), or by activation of oestrogen-independent signalling pathways. Recently the effect of exosome-mediated intercellular transfer of hormonal resistance was revealed, however, the molecular mechanism of this effect is still unknown. Here, the role of exosomal miRNAs (microRNAs) in the transferring of hormonal resistance in breast cancer cells has been studied. The methods used in the work include extraction, purification and RNAseq of miRNAs, transfection of miRNA mimetics, immunoblotting, reporter analysis and the MTT test. Using MCF7 breast cancer cells and MCF7/T tamoxifen-resistant sub-line, we have found that some miRNAs, suppressors of oestrogen receptor signalling, are overexpressed in the exosomes of the resistant breast cancer cells. The multiple (but not single) transfection of one of the identified miRNA, miR-181a-2, into oestrogen-dependent MCF7 cells induced the irreversible tamoxifen resistance associated with the continuous block of the oestrogen receptor signalling and the activation of PI3K/Akt pathway. We suppose that the miRNAs-ERα suppressors may act as trigger agents inducing the block of oestrogen receptor signalling and breast cancer cell transition to an aggressive oestrogen-independent state.
Role of Surface Preparation in Corrosion Resistance Due to Silane Coatings on a Magnesium Alloy
Authors: Saxena Abhishek , Raman R. K. Singh
Published: November 2021

Coating of an organo-silane (Bis-1,2-(TriethoxySilyl)Ethane (BTSE)) has been observed to improve the corrosion resistance of magnesium alloy AZ91D. Three different types of surface preparations have been employed before condensing the silane coating on to the substrate. Corrosion resistance was investigated using electrochemical impedance spectroscopy (EIS). A specific alkali treatment of the substrate prior to the coating has been found to improve the corrosion resistance of the coated alloy, which has been attributed to the ability of the treatment in facilitating the condensation of a relatively compact siloxane film.
Potato Peels Mediated Synthesis of Cu(II)-nanoparticles from Tyrosinase Reacted with bis-(N-aminoethylethanolamine) (Tyr-Cu(II)-AEEA NPs) and Their Cytotoxicity against Michigan Cancer Foundation-7 Breast Cancer Cell Line
Authors: Idhayadhulla Akbar , Manilal Aseer , Ahamed Anis , Alarifi Saud , Raman Gurusamy
Published: November 2021

The synthesis of nanoparticles is most important in the context of cancer therapy, particularly copper nanoparticles, which are widely used. In this work, copper(II)-tyrosinase was isolated from potato peel powder. Copper nanoparticles (Tyr-Cu(II)-AEEA NPs) were synthesized via the reaction of tyrosinase with N-aminoethylethanolamine to produce Cu(II)-NPs and these were characterized by means of FT-IR, UV-Spectroscopy, XRD, SEM, TEM and a particle size analyzer. These Tyr-Cu(II)-AEEA NPs were tested as anticancer agents against MCF-7 breast cancer cells. Fluorescence microscopy and DNA fragmentation were also performed, which revealed the inhibiting potentials of Cu(II)-AEEA NPs and consequent cell death; Tyr-Cu(II)-AEEA NPs show potential cytotoxicity activity and this nano material could be contemplated as an anticancer medicament in future investigations.
Vacancy-Induced Magnetism in Fluorographene: The Effect of Midgap State
Authors: Li Daozhi , Ma Xiaoyang , Chu Hongwei , Li Ying , Zhao Shengzhi , Li Dechun
Published: November 2021

Based on density functional theory, we have systematically investigated the geometric, magnetic, and electronic properties of fluorographene with three types of vacancy defects. With uneven sublattice, the partial defect structures are significantly spin-polarized and present midgap electronic states. The magnetic moment is mainly contributed by the adjacent C atoms of vacancy defects. Furthermore, the strain dependence of the bandgap is analyzed and shows a linear trend with applied strain. This defect-induced tunable narrow bandgap material has great potential in electronic devices and spintronics applications.
A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme
Authors: Grin Inga R. , Mechetin Grigory V. , Kasymov Rustem D. , Diatlova Evgeniia A. , Yudkina Anna V. , Shchelkunov Sergei N. , Gileva Irina P. , Denisova Alexandra A. , Stepanov Grigoriy A. , Chilov Ghermes G. , Zharkov Dmitry O.
Published: November 2021

Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the efficiency of antimetabolite drugs and is essential for virulence in some bacterial and viral infections. Thus, UNG is regarded as a promising target for antitumor, antiviral, antibacterial, and antiprotozoal drugs. Most UNG inhibitors presently developed are based on the uracil base linked to various substituents, yet new pharmacophores are wanted to target a wide range of UNGs. We have conducted virtual screening of a 1,027,767-ligand library and biochemically screened the best hits for the inhibitory activity against human and vaccinia virus UNG enzymes. Although even the best inhibitors had IC50 ≥ 100 μM, they were highly enriched in a common fragment, tetrahydro-2,4,6-trioxopyrimidinylidene (PyO3). In silico, PyO3 preferably docked into the enzyme’s active site, and in kinetic experiments, the inhibition was better consistent with the competitive mechanism. The toxicity of two best inhibitors for human cells was independent of the presence of methotrexate, which is consistent with the hypothesis that dUMP in genomic DNA is less toxic for the cell than strand breaks arising from the massive removal of uracil. We conclude that PyO3 may be a novel pharmacophore with the potential for development into UNG-targeting agents.
Similarity-Based Virtual Screen Using Enhanced Siamese Multi-Layer Perceptron
Authors: Altalib Mohammed Khaldoon , Salim Naomie
Published: November 2021

Traditional drug development is a slow and costly process that leads to the production of new drugs. Virtual screening (VS) is a computational procedure that measures the similarity of molecules as one of its primary tasks. Many techniques for capturing the biological similarity between a test compound and a known target ligand have been established in ligand-based virtual screens (LBVSs). However, despite the good performances of the above methods compared to their predecessors, especially when dealing with molecules that have structurally homogenous active elements, they are not satisfied when dealing with molecules that are structurally heterogeneous. The main aim of this study is to improve the performance of similarity searching, especially with molecules that are structurally heterogeneous. The Siamese network will be used due to its capability to deal with complicated data samples in many fields. The Siamese multi-layer perceptron architecture will be enhanced by using two similarity distance layers with one fused layer, then multiple layers will be added after the fusion layer, and then the nodes of the model that contribute less or nothing during inference according to their signal-to-noise ratio values will be pruned. Several benchmark datasets will be used, which are: the MDL Drug Data Report (MDDR-DS1, MDDR-DS2, and MDDR-DS3), the Maximum Unbiased Validation (MUV), and the Directory of Useful Decoys (DUD). The results show the outperformance of the proposed method on standard Tanimoto coefficient (TAN) and other methods. Additionally, it is possible to reduce the number of nodes in the Siamese multilayer perceptron model while still keeping the effectiveness of recall on the same level.
Bible Journaling as a Spiritual Aid in Addiction Recovery
Authors: Dillon Amanda
Published: November 2021

Bible Journaling is a trend of the past decade whereby readers make creative, visual interventions in their Bibles, using coloured pens and pencils, watercolours, stickers and stencils, highlighting texts of particular resonance. Journaling, in its more conventional written forms, has long been recognised as a pathway to spiritual development. Significantly, Bible journaling is almost exclusively practiced by women and has a high level of interpersonal interaction attached to it, through open and mutual sharing of these creations, through various online social media fora. Gleaned from the sharing of women who journal for spiritual support, this article examines the role Bible journaling plays in aiding recovery from drug addiction. Multimodal analysis is a methodological approach that provides a structured semiotic framework in which to closely examine every feature of a creation such as a journaled page of a Bible, to examine how the journaler has made meaning of a text through their interventions on the page. Appreciating every mark, choice and placement of image, colour, typography as a motivated sign revealing the interest of the creator, the sign-maker, a detailed multimodal analysis is conducted of one page of a recovered drug-user’s journaled Bible. As shall be demonstrated, profound insights into the appropriation of sacred texts for the spiritual life of a recovering addict can be gleaned in this process. Bible journaling reveals itself to be a highly valuable spiritual practice for those in addiction recovery. This interdisciplinary paper uniquely brings a methodological approach from the field of semiotics to the field of spirituality. Both the methodological approach and the subject of sacred text journaling may be of particular interest to spiritual directors, across many religions with a foundational sacred text, as a means whereby adherents can engage with a text in a deep, contemplative and creative practice that is personally, spiritually sustaining and motivating during a difficult phase of life.
Berry Cell Vitality Assessment and the Effect on Wine Sensory Traits Based on Chemical Fingerprinting, Canopy Architecture and Machine Learning Modelling
Authors: Fuentes Sigfredo , Gonzalez Viejo Claudia , Hall Chelsea , Tang Yidan , Tongson Eden
Published: November 2021

Berry cell death assessment can become one of the most objective parameters to assess important berry quality traits, such as aroma profiles that can be passed to the wine in the winemaking process. At the moment, the only practical tool to assess berry cell death in the field is using portable near-infrared spectroscopy (NIR) and machine learning (ML) models. This research tested the NIR and ML approach and developed supervised regression ML models using Shiraz and Chardonnay berries and wines from a vineyard located in Yarra Valley, Victoria, Australia. An ML model was developed using NIR measurements from intact berries as inputs to estimate berry cell death (BCD), living tissue (LT) (Model 1). Furthermore, canopy architecture parameters obtained from cover photography of grapevine canopies and computer vision analysis were also tested as inputs to develop ML models to assess BCD and LT (Model 2) and the intensity of sensory descriptors based on visual and aroma profiles of wines for Chardonnay (Model 3) and Shiraz (Model 4). The results showed high accuracy and performance of models developed based on correlation coefficient (R) and slope (b) (M1: R = 0.87; b = 0.82; M2: R = 0.98; b = 0.93; M3: R = 0.99; b = 0.99; M4: R = 0.99; b = 1.00). Models developed based on canopy architecture, and computer vision can be used to automatically estimate the vigor and berry and wine quality traits using proximal remote sensing and with visible cameras as the payload of unmanned aerial vehicles (UAV).
The X-ray Sensitivity of an Amorphous Lead Oxide Photoconductor
Authors: Grynko Oleksandr , Thibault Tristen , Pineau Emma , Reznik Alla
Published: November 2021

The photoconductor layer is an important component of direct conversion flat panel X-ray imagers (FPXI); thus, it should be carefully selected to meet the requirements for the X-ray imaging detector, and its properties should be clearly understood to develop the most optimal detector design. Currently, amorphous selenium (a-Se) is the only photoconductor utilized in commercial direct conversion FPXIs for low-energy mammographic imaging, but it is not practically feasible for higher-energy diagnostic imaging. Amorphous lead oxide (a-PbO) photoconductor is considered as a replacement to a-Se in radiography, fluoroscopy, and tomosynthesis applications. In this work, we investigated the X-ray sensitivity of a-PbO, one of the most important parameters for X-ray photoconductors, and examined the underlying mechanisms responsible for charge generation and recombination. The X-ray sensitivity in terms of electron–hole pair creation energy, W±, was measured in a range of electric fields, X-ray energies, and exposure levels. W± decreases with the electric field and X-ray energy, saturating at 18–31 eV/ehp, depending on the energy of X-rays, but increases with the exposure rate. The peculiar dependencies of W± on these parameters lead to a conclusion that, at electric fields relevant to detector operation (~10 V/μm), the columnar recombination and the bulk recombination mechanisms interplay in the a-PbO photoconductor.
Electrode Size and Placement for Surface EMG Bipolar Detection from the Brachioradialis Muscle: A Scoping Review
Authors: Merlo Andrea , Bò Maria Chiara , Campanini Isabella
Published: November 2021

The brachioradialis muscle (BRD) is one of the main elbow flexors and is often assessed by surface electromyography (sEMG) in physiology, clinical, sports, ergonomics, and bioengineering applications. The reliability of the sEMG measurement strongly relies on the characteristics of the detection system used, because of possible crosstalk from the surrounding forearm muscles. We conducted a scoping review of the main databases to explore available guidelines of electrode placement on BRD and to map the electrode configurations used and authors’ awareness on the issues of crosstalk. One hundred and thirty-four studies were included in the review. The crosstalk was mentioned in 29 studies, although two studies only were specifically designed to assess it. One hundred and six studies (79%) did not even address the issue by generically placing the sensors above BRD, usually choosing large disposable ECG electrodes. The analysis of the literature highlights a general lack of awareness on the issues of crosstalk and the need for adequate training in the sEMG field. Three guidelines were found, whose recommendations have been compared and summarized to promote reliability in further studies. In particular, it is crucial to use miniaturized electrodes placed on a specific area over the muscle, especially when BRD activity is recorded for clinical applications.
Kimiko Does Cancer
Authors: Folkmarson Käll Lisa , Tobimatsu Kimiko , Geniza Keet
Published: November 2021

KIMIKO DOES CANCER is a graphic memoir written by Kimiko Tobimatsu and illustrated by Keet Geniza. The book tells the story of Kimiko’s experience with breast cancer as a young, queer, mixed-race woman. Set in Toronto, Canada, Kimiko Does Cancer seeks to upend the traditional cancer narrative, confronting issues such as dating while in induced menopause, navigating work and treatment, and talking to well- meaning friends, health care professionals, and other cancer survivors.

In the interview below, Lisa Folkmarson Käll talks with Kimiko and Keet about their three-year long collaboration on the project, their hopes for it, the importance of representation and the difficulties of dealing with vulnerability.

Page references in the text are to Kimiko Tobimatsu and Keet Geniza’s Kimiko Does Cancer: A Graphic Memoir (Vancouver: Arsenal Pulp Press, 2020).
Rahmet Feyzî’nin Hikâyeciliği Üzerine Bir Değerlendirme
Authors: GİRAY Erhan
Published: November 2021

Modern Özbek edebiyatında önemli bir yere sahip olan Rahmet Feyzî, şiir, roman, uzun hikâye, hikâye, deneme ve film senaryosu türlerinde eserler vermiş çok yönlü bir yazardır. Feyzî, aynı zamanda iyi bir gazetecidir.
Rahmet Feyzî, 10 Ekim 1918 yılında Taşkent’in Beşağaç bölgesi Karataş mahallesinde yaşayan bir işçi ailesinde dünyaya geldi. Annesi Selamet Hanım dokuma fabrikasında, babası Feyzullah Bey ise Taşkent tramvayında işçi olarak çalıştı. Feyzullah Bey, siyasi, edebi ve sanat hayatına önem veren aydın biriydi. Rahmet Feyzî’nin güçlü bir yazar olmasında babasının etkisi büyüktür. Feyzî, çocukluğunda hem okudu hem de işçi olarak çalıştı. Ortaokulu bitirdikten sonra elektrik ve makina mühendisliği bölümünü okudu. Hayatı boyunca birçok gazetede görev alan Feyzî, 18 Kasım 1988 yılında vefat etti.
Feyzî, kırk yıllık edebî hayatı boyunca altmıştan fazla hikâye kaleme almıştır. Ancak bu hikâyelerden sadece on altısı Feyzî’nin üç ciltlik eserleri arasına dâhil edilmiştir. Makalemize kaynaklık eden bu hikâyelerde yazar, toplumsal konular, işçi sınıfının verdiği emek ve vatanperverlik temaları üzerinde durmuştur. Feyzî, bu temalarla bağlantılı olarak idealist, çalışkan ve vatanına sadık karakterler kurgulamıştır. Feyzî’nin hikâyelerinde dikkati çeken en önemli nokta ise savaş yıllarında annesini ve babasını kaybeden çocukların durumudur. Birçok hikâyesinde bu durumdaki çocukların ruh hallerini yansıtmıştır. Yazar ayrıca bu çocuklara milliyet ayrımı yapmadan şefkat gösteren Özbek halkını yüceltmiştir.
Ortak Avrupa Dil Referansi Bağlamında Yabancı Dil Olarak Türkçe Öğretiminde Kullanılan Yağmur Ders Kitaplarının Kelime Sıklığı Açısından İncelenmesi
Authors: Arslan Mustafa , Çiriş Mustafa
Published: November 2021

İnsanlığın en önemli hazinelerinden biri olan dilin öğrenilmesi oldukça zor emek isteyen bir süreçtir. Küreselleşmeyle birlikte ülkeler arası etkileşimin artmasıyla birlikte dil öğrenme faaliyetleri de hız kazanmıştır. Türkçenin yabancı dil olarak öğrenilmesinde özellikle yöntem çalışmalarına yönelik birçok araştırma yapılmaktadır ve bu araştırmalardan biri de kelime sıklığı araştırmasıdır. Kelime sıklığı çalışmaları, bir dilde sıkça kullanılan kelimeleri tespit eden araştırmalardır. Ortak Avrupa Dil Referans Bağlamında Yabancı Dil Olarak Türkçe Öğretiminde Kullanılan Yağmur Ders Kitaplarının Kelime Sıklığı Açısından İncelenmesi başlıklı yüksek tez çalışmamızda Avrupa Ortak Dil Referans Metni ışığında Yabancılara Türkçe öğretimi konusu ele alınmış, yabancı dil olarak Türkçenin öğretimi hakkında literatür ve araştırma çalışması yapılmıştır. Çalışmada A1 ve A2 seviyelerini kapsayacak biçimde 2017 senesinde Nev Lisan Yayınları’ndan çıkan Yağmur Türkçe Öğretim Seti’nin birinci ve ikinci ders kitabı referans alınarak kelime sıklığı çalışması uygulanmıştır. Bu çalışmada Ceval Kaya tarafından Türkçe için geliştirilmiş bir sıklık programı olan Cibakaya programı 2.3 sürümü kullanılmıştır. Çalışmada elde edilen bulgular neticesinde kitapta ad, eylem, önad, eylemsi, bağlaç, belirteç, adıl, ilgeç, ünlem / kalıp söz olmak üzere toplam dokuz kategoride sıralanmış, sonuç bölümünde kitaplar sıklık yönünden değerlendirilmiştir.
Information and Digital Competence as a Key Demand of Modern Ukrainian Education
Authors: Chernenko Anastasiia
Published: November 2021

Nowadays, digitalization in education is a digital transformation that is not a trend but a requirement of the times. Thus, the main task of teaching is the introduction of digital technologies, which provide education improvement, accessibility and efficiency, training the young generation for life in the digital society. Digital technologies are changed, in turn, it requires students and teachers to improve their knowledge, skills and to focus on the development. Information and digital competence in the education process helps teachers to teach the content effectively using the latest means that contribute to the achievement of the best results. With the development of key competencies, as an information and digital one, there is an urgent need to form it in the process of learning.
The article is devoted to the problem of analyzing the meaning of the term “information and digital competence” in the conditions of modern Ukrainian education.
The purpose of the article is to explore the term “information and digital competence” in scientific and pedagogic literature.
To achieve the purpose the general theoretical scientific methods are used such as analysis, synthesis and systematization of researchers’ works as for terms: “competence”, “information competence”, “digital competence”, “information and digital competence”; logical-systemic, problem-targeted, comparative analyses as for theoretical basics of components of information and digital competence.
There are some research results. The detailed analysis of terms that are related to the definition “information and digital competence” is made, and the stages of their development are considered. The particular attention is paid to the main competencies for learning.
Based on the analysis of scientific and pedagogical literature, we can conclude that the information and digital competence of specialists in various fields is an urgent issue in pedagogical science.
Use of Active Games in Physical and Tactical Training of Young Handball Players at the Initial Stage
Authors: Hrynchenko Ihor , Tykhonova Asia , Karpunets Tеtiana , Chupryna Olexandr
Published: November 2021

The purpose of the study is to increase the effectiveness of physical and technical training of young handball players aged 10-11 by means of moving games, game exercises and relays at the stage of initial training during the pedagogical experiment in 2020-2021.

Methodology. The following methods were used in the study: theoretical analysis and generalization of scientific and methodological literature, control and pedagogical checking (tests), pedagogical observations, anthropometry. Statistical processing of experimental data was performed using the statistical processing package STATGRAPHICS Plus for Windows (according to standard methods). The study involved young handball players aged 10-11, the first and second year of training in sport school №3 in Kharkiv during a year. The technique was implemented for 9 months (74 lessons), 3 times a week, and lasting 20 minutes.

Results. We claim that the physical fitness of handball players is closely related to various aspects of training. The selected tests fully characterize the physical development and functional state of the main life support systems of a body and allow determining the effectiveness of the proposed authors’ method. The specially selected combinations with the use of moving games, game exercises and relays help to increase the level of technical training of young handball players. Analysis of the final indicators in the experimental group revealed a significant increase corresponding to the 5% level of significance in terms of execution of free throws and movement in the protective rack of the handball player. The average group values of the accuracy of free throws increased by 49.5%, and the average speed of movement in the protective rack of a handball player after the experiment increased by 8.3%. The rate of transfer of the ball to the wall in the experimental group increased by 25.1%, which indicates a significant increase in the result at P <0,01.

Conclusion. The results obtained during the experiment confirmed the effectiveness of our developed methods of training with the purposeful use of moving games, game exercises and relay races at the initial stage of training young handball players.
Striving to Teach Versus Modern Realia
Authors: Nikishyna Anzhela
Published: November 2021

There have always been challenges confronting both teachers and students in the process of sharing knowledge and skills. The purpose of the article is to analyze the situation that has become even more demanding due to the changes connected with the implementation of distance learning.
Theoretical and methodological base of the research consists of an approach connected with the use of such methods as analysis, generalization and interpretation of the psychological theory of motivation and the concept of amotivation and its consequences; observation of the current educational situation with regard to its active participants.
Results focus on modern realia, when the educational conditions have been greatly changed in connection with the pandemic situation, it is possible to notice decrease of motivation among the students. Students tend to miss classes as they believe that teaching can be ineffective, prefer not to answer during the lesson, take time in handing in their homework, fellow students influence their choice of being less diligent. Technical problems or inability to participate in an active way in the process of the lesson can really worsen the situation with the desire to get proper knowledge.
Conclusion. That is why teaching big group of students and individual approach when conducting online lessons can be so challenging to teachers. It can lead to burning out while working and teacher wellbeing is also at risk, its great importance has been once again proven and highlighted.
Средство эффективного взаимодействия экспертов в системах поддержки принятия решений электронного правительства
Authors: Сапегин Сергей Виталиевич , Рябцев Геннадий Леонидович , Зубарев Елена Александровна , Басанцов Игорь Владимирович
Published: November 2021

Решена проблема низкой эффективности традиционных методов организации взаимодействия экспертов в системах поддержки принятия решений электронного правительства. Показано, что деятельность высококвалифицированного эксперта, оценки которого оказывают существенное влияние на эффективность, результативность и экономичность властных решений, недостаточно организована, систематизирована и информационно обеспечена. На основании подходов, учитывающих специфику взаимодействия экспертов между собой и с лицом, принимающим решение, сформулированы требования к автоматизированным системам экспертного оценивания. Определено их место в системах поддержки принятия решений электронного правительства. Показано, что квалифицированные пользователи — эксперты, способные оценивать (преобразовать) входные данные, генерировать варианты решений и устанавливать правила выбора лучшего из них, являются неотъемлемым «элементом» архитектуры систем поддержки принятия решений, а автоматизированные системы экспертного оценивания — их обязательным компонентом. Разработано и реализовано программное средство экспертного оценивания – автоматизированную систему PsycheaEXPERTUS. Ее апробация показала, что использование таких систем в системе электронного правительства существенно упростит экспертные процедуры, сократит непроизводительные затраты времени на организацию и проведение очных консультаций и повысит эффективность привлечения специалистов к формированию и реализации государственной политики в условиях неопределенности внешней среды и ресурсных ограничений Дальнейшие исследования планируется направить на преодоление психологической неготовности лиц, принимающих решения, к использованию систем экспертного оценивания в Украине.