bluuebunny/crossref_metadata_2025 huggingface dataset:
3-Phenylpropan-1-Amine Enhanced Susceptibility of Serratia marcescens to Ofloxacin by Occluding Quorum Sensing
Authors: Yin Lujun , Zhang Ping-Ping , Wang Wei , Tang Shi , Deng Shi-Ming , Jia Ai-Qun
Published: August 2022

Multidrug-resistant bacteria have become a major threat to global public health, leading to increased morbidity, mortality, and health care costs. Bacterial virulence factors and biofilms, which are regulated by quorum sensing (QS), are the primary causes of multidrug resistance.
Inpatient palliative care use by patients with sickle cell disease: a retrospective cross-sectional study
Authors: Nwogu-Onyemkpa Eberechi , Dongarwar Deepa , Salihu Hamisu M , Akpati Lois , Marroquin Maricarmen , Abadom Megan , Naik Aanand D
Published: August 2022

Objective

Sickle cell disease (SCD) is a highly morbid condition notable for recurrent hospitalisations due to vaso-occlusive crises and complications of end organ damage. Little is known about the use of inpatient palliative care services in adult patients with SCD. This study aims to evaluate inpatient palliative care use during SCD-related hospitalisations overall and during terminal hospitalisations. We hypothesise that use of palliative care is low in SCD hospitalisations.

Design

A retrospective cross-sectional study using data from the National Inpatient Sample from 2008 to 2017 was conducted.

Setting

US hospitals from 47 states and the District of Columbia.

Participants

Patients >18 years old hospitalised with a primary or secondary International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) or ICD-10-CM diagnosis of SCD were included.

Primary and secondary outcome measures

Palliative care service use (documented by ICD-9-CM and ICD-10-CM diagnosis codes V66.7 and Z51.5).

Results

987 555 SCD-related hospitalisations were identified, of which 4442 (0.45%) received palliative care service. Palliative care service use increased at a rate of 9.2% per year (95% CI 5.6 to 12.9). NH-black and Hispanic patients were 33% and 53% less likely to have palliative care services compared with NH-white patients (OR 0.67; 95% CI 0.45 to 0.99 and OR 0.47; 95% CI 0.26 to 0.84). Female patients (OR 0.40; 95% CI 0.21 to 0.76), Medicaid use (OR 0.40; 95% CI 0.21 to 0.78), rural (OR 0.47; 95% CI 0.28 to 0.79) and urban non-teaching hospitals (OR 0.61; 95% CI 0.47 to 0.80) each had a lower likelihood of palliative care services use.

Conclusion

Use of palliative care during SCD-related hospitalisations is increasing but remains low. Disparities associated with race and gender exist for use of palliative care services during SCD-related hospitalisation. Further studies are needed to guide evidence-based palliative care interventions for more comprehensive and equitable care of adult patients with SCD.
Long-term spill-over impact of COVID-19 on health and healthcare of people with non-communicable diseases: a study protocol for a population-based cohort and health economic study
Authors: Youn Hin Moi , Quan Jianchao , Mak Ivy Lynn , Yu Esther Yee Tak , Lau Chak Sing , Ip Mary Sau Man , Tang Sydney Chi Wai , Wong Ian Chi Kei , Lau Kui Kai , Lee Michael Shing Fung , Ng Carmen S , Grépin Karen Ann , Chao David Vai Kiong , Ko Welchie Wai Kit , Lam Cindy Lo Kuen , Wan Eric Yuk Fai
Published: August 2022

Introduction

The COVID-19 pandemic has a significant spill-over effect on people with non-communicable diseases (NCDs) over the long term, beyond the direct effect of COVID-19 infection. Evaluating changes in health outcomes, health service use and costs can provide evidence to optimise care for people with NCDs during and after the pandemic, and to better prepare outbreak responses in the future.

Methods and analysis

This is a population-based cohort study using electronic health records of the Hong Kong Hospital Authority (HA) CMS, economic modelling and serial cross-sectional surveys on health service use. This study includes people aged ≥18 years who have a documented diagnosis of diabetes mellitus, hypertension, cardiovascular disease, cancer, chronic respiratory disease or chronic kidney disease with at least one attendance at the HA hospital or clinic between 1 January 2010 and 31 December 2019, and without COVID-19 infection. Changes in all-cause mortality, disease-specific outcomes, and health services use rates and costs will be assessed between pre-COVID-19 and-post-COVID-19 pandemic or during each wave using an interrupted time series analysis. The long-term health economic impact of healthcare disruptions during the COVID-19 pandemic will be studied using microsimulation modelling. Multivariable Cox proportional hazards regression and Poisson/negative binomial regression will be used to evaluate the effect of different modes of supplementary care on health outcomes.

Ethics and dissemination

The study was approved by the institutional review board of the University of Hong Kong, the HA Hong Kong West Cluster (reference number UW 21–297). The study findings will be disseminated through peer-reviewed publications and international conferences.
Peripheral blood T-cell subset and its clinical significance in lupus nephritis patients
Authors: Wang Huijing , Lan Lan , Chen Jianghua , Xiao Liang , Han Fei
Published: August 2022

Objectives

Lupus nephritis (LN) is a common and severe manifestation of SLE. Memory T (TM) cells have been implicated in the pathogenesis of SLE. This study aimed to investigate the clinical significance of T-cell subsets in a cohort of patients with LN.

Method

The peripheral blood T cells of 24 patients with LN and 13 patients with idiopathic membranous nephropathy (iMN) were analysed by flow cytometry. SLE disease activity was evaluated by SLE Disease Activity Index-2000 (SLEDAI-2K). Patients with LN were followed up for >6 months.

Results

Patients with LN presented lower frequency of CD4+cells and higher percentage of CD8+cells than patients with iMN, which was primarily due to lower CD4+cell count. Interestingly, patients with LN under immunosuppressants had lower CD8+CD45RO+TM frequency (p=0.007), fewer regulatory CD4+T cells (p=0.04) than those without immunosuppressants. Most CD4+and CD8+TM cells in patients with LN showed an effector memory (CD45RO+CCR7+) phenotype. The frequency of CD8+CD45RO+TM cells among the CD8+T cells was negatively correlated with white blood cell count, haemoglobin, platelet and serum levels of complements C3 and C4, but was positively correlated with serum IgG, erythrocyte sedimentation rate and SLEDAI score (p<0.05 each). Consistently, the frequency of CD8+CD45RO+TM cells was higher in patients with LN with positive antidouble-stranded DNA antibody, active renal disease, extrarenal manifestations and with sclerotic glomeruli or moderate-to-severe mesangial hypercellularity in renal pathology (p<0.05). Additionally, CD8+CD45RO+TM cell frequency was significantly lower in patients with LN with renal complete remission than that in non-remission LN (18.7% vs 31.2%, p<0.05). None of these significant correlations was observed in CD4+TM cells.

Conclusion

The frequency of CD8+TM cells correlates with disease activity and treatment response to immunosuppressant in patients with LN. CD8+TM monitoring in patients with LN could provide more helpful indices for the monitoring and management of this disease.
Predictors of increase in chronicity index and of kidney function impairment at repeat biopsy in lupus nephritis
Authors: Moroni Gabriella , Porata Giulia , Raffiotta Francesca , Frontini Giulia , Calatroni Marta , Reggiani Francesco , Banfi Giovanni , Ponticelli Claudio
Published: August 2022

Objectives

Based on available data, the histological predictors of long-term outcome of lupus nephritis (LN) are not clearly defined. Aims of this retrospective study were: (i) to evaluate the change of chronicity index from the first to second kidney biopsy and to find the predictors of chronicity index increase and (ii) to detect the clinical/histological features at first and at second kidney biopsy associated with long-term kidney function impairment.

Methods

Among 203 biopsy proven LN subjects, 61 repeated kidney biopsy 49 months after the first biopsy. The reasons for repeated biopsy were: nephritic flares in 25 (41%), proteinuric flares in 21 (36%) of patients and protocol biopsy in 14 (23%) of cases.

Results

During 23-year follow-up, 25 patients presented a decrease in glomerular filtration rate (eGFR) ≥30%. At repeat biopsy, chronicity index increased in 44 participants (72%) and did not increase in 17 (28%). Nephritic syndrome and serum creatinine >1.6 mg/dL at presentation correlated with chronicity index increase (p=0.031, 0.027, respectively), cyclophosphamide therapy tended to protect against chronicity index increase (p=0.059). Kidney flares occurred in 53.6% of patients with vs 23.5% of those without chronicity index increase (p=0.035). Chronicity index increases of 3.5 points in patients with kidney flares vs 2 in those without flares (p=0.001). At second, but not at first kidney biopsy, two different models predicted eGFR decrease at multivariate analysis. The first included activity index >3 (OR: 3.230; p=0.013) and chronicity index >4 (OR: 2.905; p=0.010), and the second model included moderate/severe cellular/fibrocellular crescents (OR: 4.207; p=0.010) and interstitial fibrosis (OR: 2.525; p=0.025).

Conclusion

At second biopsy, chronicity index increased in 3/4 of participants. Its increase was predicted by kidney dysfunction at presentation and occurrence of LN flares. Kidney function impairment was predicted by both activity and chronicity index and by some of their components at repeated biopsy, but not at first biopsy.
Formally Verified Scalable Look Ahead Planning For Cloud Resource Management
Authors: Zaker Farzin , Litoiu Marin , Shtern Mark
Published: August 2022

In this article, we propose and implement a distributed autonomic manager that maintains service level agreements (SLA) for each application scenario. The proposed autonomic manager supports SLAs by configuring the bandwidth ratios for each application scenario and uses an overlay network as an infrastructure. The most important aspect of the proposed autonomic manager is its scalability which allows us to deal with geographically distributed cloud-based applications and a large volume of computation. This can be useful in look ahead optimization and in adaptations using complex models, such as machine learning. We formally prove the safety and liveness properties of the implemented distributed algorithms. Through experiments on the Amazon AWS cloud, using two different use cases, we demonstrate the elasticity and flexibility of the autonomic manager as a measure of its applicability to different cloud applications with different types of workloads. Experiments also demonstrate that increasing the size of a look ahead window, up to a certain size, improves the accuracy of the adaptation decisions by up to 50%.
Parallel Five-cycle Counting Algorithms
Authors: Shi Jessica , Huang Louisa Ruixue , Shun Julian
Published: August 2022

Counting the frequency of subgraphs in large networks is a classic research question that reveals the underlying substructures of these networks for important applications. However, subgraph counting is a challenging problem, even for subgraph sizes as small as five, due to the combinatorial explosion in the number of possible occurrences. This article focuses on the five-cycle, which is an important special case of five-vertex subgraph counting and one of the most difficult to count efficiently.

We design two new parallel five-cycle counting algorithms and prove that they are work efficient and achieve polylogarithmic span. Both algorithms are based on computing low out-degree orientations, which enables the efficient computation of directed two-paths and three-paths, and the algorithms differ in the ways in which they use this orientation to eliminate double-counting. Additionally, we present new parallel algorithms for obtaining unbiased estimates of five-cycle counts using graph sparsification. We develop fast multicore implementations of the algorithms and propose a work scheduling optimization to improve their performance. Our experiments on a variety of real-world graphs using a 36-core machine with two-way hyper-threading show that our best exact parallel algorithm achieves 10–46× self-relative speedup, outperforms our serial benchmarks by 10–32×, and outperforms the previous state-of-the-art serial algorithm by up to 818×. Our best approximate algorithm, for a reasonable probability parameter, achieves up to 20× self-relative speedup and is able to approximate five-cycle counts 9–189× faster than our best exact algorithm, with between 0.52% and 11.77% error.
Practical Software-Based Shadow Stacks on x86-64
Authors: Zou Changwei , Gao Yaoqing , Xue Jingling
Published: August 2022

Control-Flow Integrity (CFI) techniques focus often on protecting forward edges and assume that backward edges are protected by shadow stacks. However, software-based shadow stacks that can provide performance, security, and compatibility are still hard to obtain, leaving an important security gap on x86-64. In this article, we introduce a simple, efficient, and effective parallel shadow stack design (based on LLVM),
FlashStack
, for protecting return addresses in single- and multi-threaded programs running under 64-bit Linux on x86-64, with three distinctive features. First, we introduce a novel dual-prologue approach to enable a protected function to thwart the TOCTTOU attacks, which are constructed by Microsoft’s red team and lead to the deprecation of Microsoft’s RFG. Second, we design a new mapping mechanism,
Segment+Rsp-S
, to allow the parallel shadow stack to be accessed efficiently while satisfying the constraints of
arch_prctl()
and ASLR in 64-bit Linux. Finally, we introduce a lightweight inspection mechanism,
SideChannel-K
, to harden
FlashStack
further by detecting entropy-reduction attacks efficiently and protecting the parallel shadow stack effectively with a 10-ms shuffling policy. Our evaluation on
SPEC CPU2006
,
Nginx,
and
Firefox
shows that
FlashStack
can provide high performance, meaningful security, and reasonable compatibility for server- and client-side programs on x86-64.
Data ownership in software applications
Authors: Krupp Brian
Published: August 2022

Today there are many ways that we can convert our analog data into digital formats. Things such as paper receipts and stacks of notebooks piled in an office can be a thing of the past. But as we make this digital transformation and continue to invest time into the software tools that we use, the question of who owns the data is often considered. As a CS professor, a considerable amount of my personal data is stored in note taking software.
If it is not exaggeration, can it be satire?
Authors: Blumenthal Richard
Published: August 2022

A recent New York Times movie review begins, "with `Don't Look Up' Adam McKay makes a star-studded allegorical satire that shows the news media whistling past the climate-change graveyard" [2], which got me to thinking about satire with respect to computers and society
1
. The Oxford English Dictionary defines satire as

"the use of humor, irony, exaggeration, or ridicule to expose and criticize people's stupidity or vices' [1].
Clarence "skip" Ellis
Authors: Ellis Clarence
Published: August 2022

Dr Clarence "Skip" Ellis was the first African-American to receive a Ph.D. in computer science (University of Illinois at Urbana-Champaign, 1969). He is also the first African-American to be elected as a fellow of the ACM for his contributions to computer science, which include
1
:
Highlighting a few educators
Authors: Blumenthal Richard
Published: August 2022

I think of Dr. Clarence "Skip" Ellis often, a distinguished computer scientist, outstanding educator, and one of my mentors. As alluded to in the Historical Highlight on page seven of this issue, a wealth of professional and personal information about Skip is easily found on the internet. I've highlighted a few of his professional achievements in the accompanying highlight. In this inaugural
Acknowledging Our Social Good Mentors
piece
1
, I'd like to add my small part to the narrative associated with this wonderful person by relating a few things that, perhaps, only I know or think about. All of which, either overtly or subtlety, have influenced my passion and work related to computing for the common good. I'll begin at the end, so to speak.
The computation urge to... DIY social media
Authors: Gulley Paige , Voth Alissa
Published: August 2022

We are in an era of polarized and pessimistic self-reflection on the state of the internet. As we grapple with the destructive impacts of the modern arrangement of the social web, it's worth remembering that the technology which underpins these giants is more accessible than ever before to those who want to use it to pursue their own ends. We believe that in the hands of thoughtful independent developers the internet stll holds tremendous promise to positively shape our culture at local levels.
The differential roles of the two NO-GC isoforms in adjusting airway reactivity
Authors: Verheyen Malte , Puschkarow Michelle , Gnipp Stefanie , Koesling Doris , Peters Marcus , Mergia Evanthia
Published: August 2022

The enzyme, nitric oxide-sensitive guanylyl cyclase (NO-GC), is activated by binding NO to its prosthetic heme group and catalyzes the formation of cGMP. The NO-GC is primarily known to mediate vascular smooth muscle relaxation in the lung, and inhaled NO has been successfully used as a selective pulmonary vasodilator. In comparison, NO-GC’s impact on the regulation of airway tone is less acknowledged and, most importantly, little is known about the issue that NO-GC signaling is accomplished by two isoforms: NO-GC1 and NO-GC2, implying the existence of distinct “cGMP pools.” Herein, we investigated the functional role of the NO-GC isoforms in respiration by measuring lung function parameters of isoform-specific knockout (KO) mice using noninvasive and invasive techniques. Our data revealed the participation and ongoing influence of NO-GC1-derived cGMP in the regulation of airway tone by showing that respiratory resistance was enhanced in NO-GC1-KOs and increased more pronouncedly after the challenge with the bronchoconstrictor methacholine. The tissue resistance and stiffness of NO-GC1-KOs were also higher because of narrowed airways that cause tissue distortion. Contrariwise, NO-GC2-KOs displayed reduced tissue elasticity, elastic recoil, and airway reactivity to methacholine, which did not even increase in an ovalbumin model of asthma that induced hyperresponsiveness in NO-GC1-KOs. In addition, conscious NO-GC2-KOs showed a higher breathing rate with a shorter duration of inspiration and expiration time, which remained faster even in the presence of bronchoconstrictors that slow down breathing. Thus, we provide evidence of two distinct NO/cGMP pathways in airways, accomplished by either NO-GC1 or NO-GC2, adjusting differentially the airway reactivity.
[Retracted] Personalised Recommendation of PE Network Course Environment Resources Using Data Mining Analysis
Authors: Min Fanting
Published: August 2022

PE education reform is positively influenced by the creation and use of resources for PE courses as a supplement to and development of traditional teaching strategies. In order to mine the vast amount of data in the network PE curriculum resource system and find useful patterns, this paper uses highly automated DM technology. Additionally, you can forecast users’ upcoming actions and suggest particular course resources to them. This recommendation system makes course resources that users might be interested in based on their browsing history, browsing patterns, and browsing preferences. User registration and login, course retrieval, browsing history, course recommendation, and a module for course scoring are among the system’s primary features. Studies reveal that this method’s recommendation accuracy is up to 96.2 percent, or about 10% higher than that of conventional recommendation methods. The recommendation strategy put forth in this paper has a good recommendation effect, high accuracy, and coverage. It also plays a part in improving the hidden semantic model’s accuracy. For individualised curriculum resource recommendations, this recommendation system offers a good solution.
[Retracted] Human Resource Data Integration System Based on Artificial Intelligence Environment
Authors: Xie Fei
Published: August 2022

In an AI environment, this article suggests an HR data integration system based on a hidden semantic model to address the low integration of HR raw data. It provides a decision‐making framework for enterprise personnel recruitment and employee training by making predictions and analyses based on HR information. The basis for the HR data integration model base is established in this article, along with its construction principle, process, and model types. Based on this, a method for creating an HR data integration system that has a straightforward modeling process, an easy solution, high prediction accuracy, verifiability, and correction is chosen. An HR recommendation algorithm combining a hidden semantic model and a deep forest model is proposed. At the same time, preprocess HR data and create a data warehouse. According to experiments, this system’s stability can reach a maximum of 95.84 percent and its efficiency in integrating HR data can reach 96.37 percent. The system operates with ease and consistently delivers superior performance. It can more effectively realize the fusion and mining of HR data and offer practical services for related work.
[Retracted] Effect Evaluation of Bronchial Artery Embolization for Hemoptysis of Lung Cancer and Changes in Serum Tumor Markers and miR‐34 Levels
Authors: Huang Yan , Liang Hongxiang , Yang Zhiyong , Liu Hedai , Xu Judi , Huang Ying , Huang Qian , Ni Guoying , Ni Yufeng
Published: August 2022

The clinical efficacy, serum tumor markers, and miR‐34 expression levels of bronchial artery embolization (BAE) in patients with lung cancer with hemoptysis are investigated. 92 patients with lung cancer hemoptysis treated in our hospital from January 2019 to December 2021 are randomly selected, and 92 patients are randomly divided into the conservative group and the BAE group according to the number table method, with 46 patients in each group. The efficacy, overall survival (OS) rate, coagulation function, hemoptysis volume, serum tumor markers, and miR‐34 expression are compared among all groups at different time points. The experimental results show that the BAE treatment can promote the expression of miR‐34 and inhibit the expression of tumor markers, so it can improve the efficacy of patients with lung cancer hemoptysis, improve the symptoms of hemoptysis and coagulation function, and prolong the life cycle of patients.
Waveform Characteristics of Tunnel Blast Waves and a Wave-Blocking Method
Authors: Zhou Xianshun , Zhang Xuemin , Ren Tianhe , Ou Xuefeng , Xiong Wenchao , Zhang Liming , Zhang Lei
Published: August 2022

The impact of blast wave air overpressure (AOp) may cause damage to nearby structures and significant noise pollution. In order to minimize the impact of the blast wave on the buildings around the tunnel, a new wave-blocking trolley (NWBT) was proposed to control the AOp during the construction of the Baitacun tunnel, as the nearby villages were located less than 100 m from the tunnel portal. In the study, the characteristics of the blast wave pressure profiles were studied by field measurements and numerical simulations and the Friedlander equation parameters were obtained. Second, the controlling effect and working mechanism of the NWBT were verified to be effective. The measured peak AOp was weakened from 2.49 kPa to 0.55 kPa with the operating NWBT, which meets the requirements of Chinese specifications. Furthermore, a numerical simulation for the impact process of the NWBT was established using the ANSYS/LS-DYNA software. Finally, it was found that a shorter distance from the NWBT to the source of the blast makes a better contribution to its wave-blocking effect. The waveform characteristics obtained in the study contribute to the design of tunnel surrounding structures; the application of the NWBT is a successful wave-blocking method for tunnels adjacent to environmentally sensitive areas.
Optimization of Students’ Performance Prediction through an Iterative Model of Frustration Severity
Authors: Ahmad Sadique , Ben Aoun Najib , Affendi Mohammed A. El , Anwar M. Shahid , Abbas Sidra , Latif Ahmed A. Abd El
Published: August 2022

Recent articles reported a massive increase in frustration among weak students due to the outbreak of COVID-19 and Massive Open Online Courses (MOOCs). These students need to be evaluated to detect possible psychological counseling and extra attention. On the one hand, the literature reports many optimization techniques focusing on existing students’ performance prediction systems. On the other hand, psychological works provide insights into massive research findings focusing on various students’ emotions, including frustration. However, the synchronization among these contributions is still a black box, which delays the mathematical modeling of students’ frustration. Also, the literature is still limited in using insights of psychology and assumption-based datasets to provide an in-house iterative procedure for modeling students’ frustration severity. This paper proposes an optimization technique called the iterative model of frustration severity (IMFS) to explore the black box. It analyzes students’ performance via two modules. First, frustration is divided into four outer layers. Second, the students’ performance outcome is split into 34 inner layers. The prediction results are iteratively optimized under the umbrella of frustration severity layers through the outer and inner iterations. During validation, the IMFS achieves promising results with various evaluation measures.
A Design Model of Music Teaching and Auxiliary System Based on Artificial Neural Networks
Authors: Chen Bo
Published: August 2022

The Internet has now ingrained itself into every aspect of people’s lives and has grown to be a necessity. Machine learning technology is applied to the design of music teaching and teaching assistant systems with the aim of bringing convenience to students and teachers in teaching and learning and improving teaching efficiency and quality through the design and implementation of a friendly and interactive intelligent music assistant teaching system. The B/S mode framework aids in the realisation of the hierarchy and module structure of the system design during the system implementation process. Last but not least, this paper looks at the system modules, confirms all of the system’s operations, and makes sure each functional module is working properly. The algorithm is straightforward, effective, simple to use, and user-friendly, and the system is expandable, portable, and transparent. It is an excellent teaching tool for music.
Applying Noise‐Based Reverse Correlation to Relate Consumer Perception to Product Complex Form Features
Authors: Diego-Mas Jose Antonio , Alcaide-Marzal Jorge , Poveda-Bautista Rocio
Published: August 2022

Consumer behavior knowledge is essential to designing successful products. However, measuring subjective perceptions affecting this behavior is a complex issue that depends on many factors. Identifying visual cues elicited by the product’s appearance is key in many cases. Marketing research on this topic has produced different approaches to the question. This paper proposes the use of Noise‐Based Reverse Correlation techniques in the identification of product form features carrying a particular semantic message. This technique has been successfully utilized in social sciences to obtain prototypical images of faces representing social stereotypes from different judgements. In this work, an exploratory study on subcompact cars is performed by applying Noise‐Based Reverse Correlation to identify relevant form features conveying a sports car image. The results provide meaningful information about the car attributes involved in communicating this idea, thus validating the use of the technique in this particular case. More research is needed to generalize and adapt Noise‐Based Reverse Correlation procedures to different product scenarios and semantic concepts.
Design and Practical Application of Sports Visualization Platform Based on Tracking Algorithm
Authors: Hua Xia , Han Lei
Published: August 2022

Machine learning methods use computers to imitate human learning activities to discover new knowledge and enhance learning effects through continuous improvement. The main process is to further classify or predict unknown data by learning from existing experience and creating a learning machine. In order to improve the real-time performance and accuracy of the distributed EM algorithm for machine online learning, a clustering analysis algorithm based on distance measurement is proposed in combination with related theories. Among them, the greedy EM algorithm is a practical and important algorithm. However, the existing methods cannot simultaneously load a large amount of social information into the memory at a time. Therefore, we created a Hadoop cluster to cluster the Gaussian mixture model and check the accuracy of the algorithm, then compare the running time of the distributed EM algorithm and the greedy algorithm to verify the efficiency of the algorithm, and finally check the scalability of the algorithm by increasing the number of nodes. Based on this fact, this article has conducted research and discussion on the visualization of sports movements, and the teaching of visualization of sports movements can stimulate students’ interest in physical education. The traditional physical education curriculum is completely based on the teacher’s oral explanation and personal demonstration, and the emergence of visualized teaching of motor movements broke the teacher-centered teaching model and made teaching methods more interesting. This stimulated students’ interest in sports and improved classroom efficiency.
[Retracted] Intestinal Flora Balance Therapy Based on Probiotic Support Improves Cognitive Function and Symptoms in Patients with Alzheimer’s Disease: A Systematic Review and Meta‐analysis
Authors: Liu Changxing , Guo Xinyi , Chang Xiang
Published: August 2022

Objective. The clinical value of intestinal flora balance therapy based on probiotic support in improving cognitive function and symptoms of patients with Alzheimer’s disease was to systematically evaluate, so as to provide evidence‐based medicine basis for the promotion and use of this therapy. Methods. The randomized controlled trials (RCTs) were searched for the improvement of cognitive function and symptoms of patients with Alzheimer’s disease by intestinal flora balance therapy supported mainly by probiotics in PubMed, EMBASE, ScienceDirect, Cochrane Library, China Knowledge Network Database (CNKI), China VIP database, Wanfang database, and China Biomedical Literature Database (CBM) online database (RCT). Data were extracted independently by two researchers, and the literature was assessed for risk of bias according to the Cochrane Handbook 5.1.0 criteria. The data were meta‐analyzed using RevMan 5.4 statistical software. Results. Finally, 5 randomized controlled trials were included, with a total sample size of 386 cases. The results of meta‐analysis showed that Chi2 = 13.14, df = 2, P = 0.001, and I2 = 85% showed significant heterogeneity in the inclusion of the study data. Probiotic‐supported intestinal microflora balance therapy improves cognitive function in patients with Alzheimer’s disease. Through meta‐analysis of transient memory scores, it is concluded that intestinal flora balance therapy based on probiotic support can improve transient memory in patients with Alzheimer’s disease. Meta‐analysis of ADAS‐COG score showed that intestinal flora balance therapy supported by probiotics could improve the cognitive function of patients with Alzheimer’s disease. The ADL score was analyzed by meta, and the heterogeneity test result was Chi2 = 0.79, df = 1, P = 0.37 > 0.05, and I2 = 0%, indicating that the intestinal flora balance therapy supported by probiotics can improve the ability of daily living of patients with Alzheimer’s disease. Conclusion. Intestinal flora balance therapy based on probiotic support can effectively improve cognitive function, instantaneous memory, and ability of daily life in patients with Alzheimer’s disease. However, more studies and long‐term follow‐up studies with higher methodological quality are needed to further verify.
Relation of Malnutrition and Nosocomical Infections in Cancer Patients in Hospital: An Observational Study
Authors: Muresan Bianca Tabita , Núñez‐Abad Martín , Artero Ana , Rios Rios Jaime , Cunquero-Tomás Alberto Jacobo , Iranzo Vega , Garrido Javier , Jiménez-Portilla Ana , Camps Herrero Carlos , Sánchez Juan Carlos J.
Published: August 2022

Aim. To investigate the relation between malnutrition and nosocomial infections (NI) in hospitalized cancer patients. Methods. This observational, cross-sectional, noninterventional, descriptive study was conducted in a 500-bed university hospital in Valencia (Spain). Adult cancer patients admitted to the oncology ward were consecutively enrolled regardless of their nutritional status between November 2019 and March 2020. Patients were nutritionally assessed 24 to 48 hours after admission. Body weight, height and BMI, body composition through measurement of bioelectrical impedance analysis (BIA), and muscle strength and functionality using hand grip strength (HGS) were prospectively collected. The diagnosis of malnutrition and sarcopenia was assessed using the Global Leadership Initiative on Malnutrition (GLIM) criteria and the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, respectively. Patients were followed up during their hospital stay or outpatient oncology visits to identify possible NI. Results. A total of 107 patients were included in this study (mean age 66 years; 66.4% were men). The most frequent reason for admission was cancer treatment (19.6%), followed by infections (18.7%) and digestive tract symptoms (18.7%). Overall, 77.5% (83/107) of the patients were malnourished at admission according to the GLIM criteria, while 52.3% (56/107) were sarcopenic. Nosocomial infections (NI) were significantly more frequent in malnourished (52.1%; 25/48) and severely malnourished (42.1%; 8/19) patients, compared with well-nourished patients without malnutrition (25%; 10/40;

p
=
0.035

). The mean length of hospital stay was 13.9 days, significantly longer in patients with an NI compared to those without infections (18.6 vs. 10.8 days,

p
<
0.024

). Conclusion. This study evidenced the need to implement a routine protocol for the nutritional assessment and support of cancer patients at risk of malnutrition and sarcopenia to reduce the risk of NI during their hospital stay.
The Construction Path and Protection Measures of Wetland Park from the Perspective of National Participation in the New Era
Authors: Li Liping , Li Lifen
Published: August 2022

In order to study many problems, such as unreasonable wetland protection, development, and utilization, resulting in a large reduction of wetland area, and so on, with the rise of the construction and research upsurge of the municipal wetland park, a method of wetland park construction path and protection measures based on the perspective of the new era of national participation was proposed. This method takes the construction of urban wetland parks as the research object, starts with the actual demand for wetland parks from the perspective of urban residents’ health in the new era, and discusses the construction path and related protection measures of wetland parks from the perspective of national participation. The results show that urban wetland park is an important green infrastructure in the region. In addition, it should have elastic adaptability, complex benefits, and special regional characteristics, to create an elastic dynamic system that can adapt to changes in planning and design, improve social public service functions, set up public access points, stimulate media benefits, and integrate regional characteristics.
Modeling and Optimization for a New Compliant 2-dof Stage for Locating Biomaterial Samples by an Efficient Approach of a Kinetostatic Analysis-Based Method and Neural Network Algorithm
Authors: Dang Minh Phung , Le Hieu Giang , Van Minh Nhut , Chau Ngoc Le , Dao Thanh-Phong
Published: August 2022

The nanoindentation technique is employed to characterize the behaviors of biomaterials. Nevertheless, there is a lack of development of a miniaturized precise positioner for in situ nanoindentation. Besides, modeling behaviors of the positioner are restricted due to its complex kinematic characteristics. Therefore, this paper proposes a novel compliant two degrees of freedom (dof) stage for positioning a biomaterial sample in in situ nanoindentation. In addition, a new modeling and dimensional optimization synthesis method of the stage is developed. The proposed effective methodology is developed based on a kinetostatic analysis-based calculation method, the Lagrange approach, and a neural network algorithm. With an increased advance in artificial intelligence, a neural network algorithm is proposed to extend the applicability of artificial neural networks in optimizing the parameters of the stage. First, the 2-dof stage is built via a combination of an eight-lever displacement amplifier and a symmetric parallelogram mechanism. Second, a chain of mathematical equations of the 2-dof stage is constructed using a kinetostatic analysis-based method to calculate the ratio of displacement amplification and the input stiffness of the 2-dof stage. Then, the Lagrange method is utilized to formulate the dynamic equation of the 2-dof stage. Finally, a neural network algorithm is adopted to maximize the natural first frequency of the proposed stage. The optimal results determined that the frequency of the stage can achieve a high value of 112.0995 Hz. Besides, the formed mathematical models were relatively precise by comprising the simulation verifications.
Effects of Acupuncture Combined with Exercise on Expression of Immune Factors in Aging Rats and Its Significance in Antiaging Intervention
Authors: Jiang Lulu , Jing Hongying , Lan Lan , Liu Xia , Wang Su , Xu Yan , Meng Nijia
Published: August 2022

Background. With the improvement of people’s living standards, how to maintain health and delay aging to improve the quality of life and achieve longevity has become a hot topic of concern. objective. To investigate the effect of acupuncture combined with exercise on the expression of immune factors in aging rats and its significance in antiaging intervention. Materials and Methods. Forty-three SD rats included 12 rats in the control group, and the remaining rats were injected intraperitoneally with D-galactose 500 mg/kg to prepare a subacute aging rat model. The 24 rats that were successfully modeled were divided into acupuncture exercise groups and exercise groups according to the random number table method, with 12 rats in each group. After the modeling, the comparison group did not do any intervention, the exercise group was given aerobic exercise intervention, and the acupuncture exercise group was given acupuncture combined with exercise intervention. The effect of immune factor expression in rats was compared. Results. The levels of IgM, IgA, and IgG in the acupuncture exercise group were significantly higher than those in the exercise group (

P
<
0.05

). The IL-10 content in the acupuncture exercise group was significantly higher than that in the exercise group (

P
<
0.05

) and was significantly reduced in the acupuncture exercise group compared with the comparison group (

P
<
0.05

). The level of IL-6 in the acupuncture exercise group was significantly lower than that in the exercise group, and the level of IL-6 in the acupuncture exercise group was significantly increased compared with the comparison group (

P
<
0.05

). The C3 and C4 levels in the acupuncture exercise group were significantly higher than those in the exercise group (

P
<
0.05

). The levels of IFN-γ and TNP-α were significantly lower in the acupuncture exercise group than in the exercise group and significantly increased in the acupuncture exercise group compared with the comparison group (

P
<
0.05

). Conclusion. Ling turtle eight method acupuncture combined with exercise promoted the development of immune organ spleen, enhances the body’s immune function and complement system, inhibits the immune inflammatory response and regulates immune balance, reduces the inflammatory response caused by the aging of D-type galactose, and achieves the effect of delaying aging.
Coupling and Coordination of the Regional Economy, Tourism Industry, and Exhibition Industry of China’s Provinces
Authors: Lu Mengyuan
Published: August 2022

There is a close correlation between regional economy, tourism, and exhibition industry. By constructing a system of evaluation indicators for the regional economy, tourism industry, and exhibition industry, the coupled coordination degree model was used to calculate the degree of synergy of the regional economy, tourism industry, and exhibition industry in China from 2013 to 2019. In addition, the influencing factors of the degree of synergy were analyzed by gray correlation analysis. As shown by the results, the comprehensive development scores of regional economy, tourism industry, and exhibition industry show an overall growth trend, while the development level index presents a spatial distribution pattern of decreasing gradient from coastal area to inland in space. Apart from that, the integration and development of regional economy, tourism industry, and exhibition industry show a continuous coordinated and benign development. On a national scale, the degree of integration of the regional economy‐tourism industry‐exhibition industry in China has gradually developed and improved from bare coordination to good coordination. Besides, the degree of coupling and coordination of regional economy‐tourism‐exhibition industry varies greatly among provinces. Moreover, all the indexes have a strong impact on the coupling and coordination degree of the regional economy‐tourism industry‐exhibition industry. Compared with the exhibition industry system, the economic system and tourism system have a stronger impact on the coupling and coordination degree of the regional economy‐tourism industry‐exhibition industry.
Application of PDCA Circulation Regulation Combined with Nursing Mark in Nursing Safety and Quality Regulation of Disinfection Supply Center
Authors: Cai Xiuyu , Li Jun , Li Wen
Published: August 2022

Objective. A case-control study was conducted to explore the application value of PDCA cycle regulation combined with nursing label in nursing safety and quality regulation in disinfection supply centers. Methods. The medical staff in the disinfection supply center of our hospital from January 2020 to December 2020 and from January 2021 to December 2021 were included in the control group (routine nursing regulation, n = 13) and the research group (PDCA circulation nursing regulation, n = 13). The differences in quality evaluation, disinfection qualification, quality regulation effect, supply satisfaction, job satisfaction, safety awareness, and comprehensive operation skills of nursing staff were compared, and the application value of PDCA cycle regulation combined with nursing label in nursing safety and quality regulation of disinfection supply center was comprehensively analyzed. Results. The quality score of nursing staff, and quality evaluation in the study group was significantly higher than that in the control group, and the difference was statistically significant (

P
<
0.05

). The disinfection qualification rate of nurses in the research group was significantly higher, and the difference was statistically significant (

P
<
0.05

). The effect of device quality supervision in the study group was significantly improved, and the difference was statistically significant (

P
<
0.05

). The scores of various supervisions in the study group were significantly higher than those in the control group, and the difference was statistically significant (

P
<
0.05

). The safety recognition ability, risk prevention awareness, service awareness, and theory and operation scores of nurses in the study group were significantly higher than those in the control group, and the difference was statistically significant (

P
<
0.05

). The incidence of adverse events in the study group was lower, and the difference was statistically significant (

P
<
0.05

). The satisfaction of the research group was significantly higher than that of the control group, and the difference was statistically significant (

P
<
0.05

). Conclusion. In summary, the implementation of the PDCA cycle supervision method in the supervision of the sterile supply center in conjunction with the nursing logo is conducive to improving the quality of supervision and sterilization of all work aspects of the sterile supply center, reducing the occurrence of adverse nursing events and promoting the job satisfaction of nurses. In addition, it is conducive to standardizing the operational processes of staff, improving self-learning awareness enhancement, and improving work quality and efficiency.
Effects of Exosomal microRNAs on Oral Mucosal Epithelial Cells Cocultured with Limbal Niche Cells
Authors: Guo Xiaoyu , Xiao Yuting , Xu Amin , Duan Chaoye
Published: August 2022

Autologous cultivated oral mucosal epithelial transplantation (COMET) is an important method for the treatment of limbal stem cell deficiency (LSCD), but the appearance of peripheral corneal neovascularization after COMET has prevented its widespread use in clinical practice. Using limbal niche cells (LNCs) as feeders in the process of coculturing could inhibit the postoperative corneal neovascularization. However, the specific mechanism is still unclear. In this study, LNCs were used as feeder cells to alter the phenotype of cultured oral mucosal epithelial cells (COMECs) by mimicking the primitive limbal microenvironment. The high‐throughput sequencing of COMECs cocultured with LNCs or 3T3 cells (named LNCs group and 3T3 groups) was performed, and differential miRNA expression was analyzed. A total of 99 known and 1 newly predicted miRNAs were significantly upregulated in the LNCs group, while 101 known and 8 newly predicted miRNAs were significantly downregulated. A total of 3000 target genes with the 60 most significantly differentially expressed miRNAs were predicted, and 7 upregulated and 7 downregulated miRNAs were ultimately screened. The supernatants obtained from both cocultures were found to be rich in exosomes, indicating that the intercellular communication between COMECs and LNCs or 3T3 cells was highly active. Furthermore, the expression levels of rno‐miR‐200‐5p, rno‐miR‐204‐5p, rno‐miR‐126a‐3p, rno‐miR‐192‐5p, rno‐miR‐211‐5p, rno‐miR‐143‐3p, and rno‐miR‐184 were significantly higher in the LNCs group compared to the 3T3 group, and the expression levels had a similar trend in exosomes. Meanwhile, sequencing of the cell lines revealed 7 miRNAs that were significantly downregulated in the LNCs group. Interestingly, in that case, rno‐miR‐23a‐3p, rno‐miR‐379‐5p, and rno‐miR‐127‐5p were also significantly downregulated in the exosomes. In summary, this study suggested that signal transduction between cells mediated by exosomal miRNAs may be an important factor for the inhibition of angiogenesis by LNCs nourished COMECs.