OP0251 DATA-DRIVEN DEFINITIONS BASED ON INFLAMMATORY LESIONS FOR A POSITIVE MRI OF THE SPINE CONSISTENT WITH AXIAL SPONDYLOARTHRITIS
Authors: Maksymowych W. P. , Lambert R. G. , Baraliakos X. , Juhl Pedersen S. , Weber U. , Eshed I. , Machado P. , De Hooge M. , Sieper J. , Wichuk S. , Poddubnyy D. , Rudwaleit M. , Van der Heijde D. , Landewé R. B. M. , Østergaard M. 
Published: May 2021

Background:

The ASAS definition of a positive MRI for inflammation in the spine (ASAS-MRIspine+) is intended for classification of patients as having axSpA but is often misused for diagnostic purposes. This is problematic because bone marrow edema (BME) in the spine may occur in 20-40% of those with mechanical back disorders. The ASAS MRI group has generated updated consensus lesion definitions which have been validated on MRI spine images from the ASAS Classification Cohort.

Objectives:

We aimed to identify quantitative cut-offs based on numbers of vertebral corners that define ASAS-MRIspine+, there being two gold standards: A. majority central reader decision as to the presence of spine MRI findings consistent with axSpA B. rheumatologist expert opinion diagnosis of axSpA.

Methods:

Eight ASAS-MRI readers recorded MRI lesions in the spine according to recently updated ASAS definitions from 62 cases in an eCRF that comprises global assessment (MRI consistent with axSpA? (yes/no)), and detailed scoring of lesions for all sites in the spine. We calculated sensitivity and specificity for numbers of vertebral corners with BME where a majority of readers (≥5/8) agreed as to the presence of MRI findings consistent with axSpA. We selected cut-offs with ≥95% specificity. These cut-offs were analyzed for their predictive utility for rheumatologist diagnosis of axSpA by calculating positive and negative predictive values (PPV, NPV) and selecting cut-offs with PPV ≥95%. Both criteria were considered requirements for designation of MRI cut-offs defining ASAS-MRIspine+.

Results:

MRI findings consistent with axSpA were observed by majority read in 8 (20%) of 40 cases diagnosed with axSpA, and 0 (0%) of 19 cases without axSpA. Cut-offs achieving specificity of ≥95% for MRI findings consistent with axSpA were 4 vertebral corners (sensitivity 75%) for all cases, 3 vertebral corners (sensitivity 37.5%) for cases with ≥1 additional location with inflammation, 1 vertebral corner (sensitivity 62.5%) in cases with ≥2 vertebral corner fat lesions (Table 1). All of the above cut-offs also had very high PPV (≥95%) for diagnosis of axSpA in cases diagnosed by the rheumatologist (Table 2).

Table 1.

Majority readers agree MRI findings consistent with axSpA are present is the gold-standard external reference

MRI cut-offsSensitivity (95%CI)Specificity (95%CI)BME in ≥2 vertebral corners87.5 (47.3 - 99.7)87.0 (75.1 - 94.6)BME in ≥ 3 vertebral corners87.5 (47.3 - 99.7)94.4 (84.6 - 98.8)BME in ≥4 vertebral corners75.0 (34.9 - 96.8)98.2 (90.1 - 100.0)Cases with ≥1 additional non-corner site inflammatory lesionBME in ≥2 vertebral corners37.5 (8.5 - 75.5)94.4 (84.6 - 98.8)BME in ≥3 vertebral corners37.5 (8.5 - 75.5)98.2 (90.1-100.0)Cases with ≥2 vertebral corner fat lesionsBME in ≥1 vertebral corner62.5 (24.5 - 91.5)100.0 (93.4-100.0)BME in ≥2 vertebral corners62.5 (24.5 - 91.5)100.0 (93.4-100.0)Table 2.

Predictive values of cut-offs for number of vertebral corners with BME according to the diagnostic ascertainment of the rheumatologist

MRI cut-offsSensitivity (95%CI)Specificity (95%CI)PPVNPVMRI findings consistent with axSpA ≥any 2 readers52.5 (36.1 - 68.5)94.7 (74.0 - 99.9)95.5 (75.3 - 99.3)48.6 (40.2 - 57.2)MRI findings consistent with axSpA ≥majority read20.0 (9.1 - 35.6)100.0 (82.4 - 100.0)100.037.3 (33.7 - 40.9)BME in ≥ 4 vertebral corners17.5 (7.3 - 32.8100.0 (82.4 - 100.0)100.036.5 (33.3 - 39.9)Cases with ≥1 additional inflammatory lesionBME in ≥ 3 vertebral corners10.00 (2.8 - 23.7)100.00 (82.4 - 100.0)100.034.5 (32.2 - 36.9)Cases with ≥2 vertebral corner fat lesionsBME in ≥1 vertebral corner12.50 (4.2 - 26.8)100.00 (82.4 - 100.0)100.035.2 (32.6 - 37.9)

Conclusion:

A cut-off of BME in ≥4 vertebral corners, or ≥3 corners in the setting of additional inflammatory lesions at other locations or corner fat, are primary candidates for defining ASAS-MRIspine+. These cut-offs apply to typical patients referred to a rheumatologist with a high index of suspicion of axSpA and may not be appropriate in other populations.

Disclosure of Interests:

None declared