bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Keamanan Fisik Data Prodi Sistem Informasi UIN Sumatera Utara Medan Menggunakan Standar ISO 27001
Authors: Yahya Harun , Aznur Mahzura , Agnestesia Nadila , Ikhwan Ali
Published: August 2023

Physical security is the first step in computer security. If physical storage is not properly secured, data, even the computer applications themselves, cannot be guaranteed to be secure. Analysis of Physical Data Security of the Information Systems Study Program UIN North Sumatra Medan using point A.9 of the ISO 27001 Standard. Analysis of the physical security of the information system study program data was carried out through literature review, use of ISO 27001 points, interviews with related parties regarding the physical security of the current study program data. This study aims to find out the details and problems faced by the Medan North Sumatra UIN Information Systems Study Program in using its physical security system.
Perancangan Aplikasi Multimedia Berbasis Android Dalam Pembelajaran Membaca Tingkat Taman Kanak-Kanak
Authors: Yolanda Adhe Eva , Wanandi Bagus Sopian , Yahya Harun , Fiddarain Syaidah , Ikhwan Ali
Published: August 2023

Untuk menciptakan suasana belajar yang dapat diterima di kondisi apapun dibantu dengan adanya media pembelajaran. Banyak wadah pembelajaran yang sudah ada sampai saat ini, ada yang gratis dan ada yang berbayar. Sebuah aplikasi multimedia pembelajaran ini merupakan  seperangkat perangkat keras maupun pernagkat lunak berbasis teknologi digital yang digunakan untuk menjabarkan pesan informasi dalam proses pembelajaran agar dapat dijangkau dimana saja dan kapan saja pada perangkat seluler android tersebut. Dalam kegiatan belajar membaca tersebut terdapat media yang menarik sehingga tidak terlalu monoton. Tujuan dari perancangan aplikasi ini untuk mempermudah penyampaian materi untuk menambah semangat anak-anak yang senang belajar membaca.
Uji Aktivitas Antioksidan Ekstrak Etanol Biji Jambu Bol (Syzygium Malaccense (L.) Merr. & Perry) Dengan Metode 1,1-Diphenyl-2-Picryhidrazyl (DPPH)
Authors: Devitria Rosa , Elfia Mega , Cahyani Manisha Tri
Published: August 2023

Many plants include antioxidant chemicals in their blooms, leaves, and fruit. Antioxidants are substances that slow, stop, or stop the oxidation process. Various antioxidant chemicals have the capacity to block oxidative processes, allowing body cells to recover from oxidative damage. Malay apple has a lot of antioxidant and anti-inflammatory properties. Malay apple flesh, seeds, and leaves include phenolic chemicals, flavonoids, and carotenoids, all of which have antioxidant properties. The IC50 value will be used to measure the antioxidant activity of guava seed ethanol extract in this investigation. The seeds of the malay apple were extracted using the maceration process using ethanol as the solvent. The antioxidant activity of the concentrated extract was then determined using the 1,1-Diphenyl-2-Picryhydrazyl (DPPH) method, which uses a small, simple, fast, and easy sample to activate the antioxidant activity of natural substances. This study took place between April and May of 2022. The IC50 value was determined to be 3,511 ppm. The antioxidant activity in this study exhibits substantial antioxidant activity to fight free radicals, according to the IC50 value obtained.
Kemacetan Lalu Lintas Pada Simpang Tak Bersinyal Di Simpang Tiga Kampung Kalawi Padang Sumatera Barat
Authors: Zayu Wiwin Putri , Sarda Sarda , Boy Wendy
Published: August 2023

Simpang Tiga Kampung Kalawi merupakan simpang tak bersinyal yang memiliki tiga kaki simpang yang terletak di jalan Raya Kalawi Kota Padang. Tujuan penelitian ini adalah untuk mengetahui besarnya hambatan samping yang mempengaruhi kemacetan lalu lintas pada Simpang Tiga Kampung Kalawi, mengetahui kinerja jalan pada simpang, mengetahui tingkat kemacetan serta memberikan alternative penanganan solusi kemacetan yang ada di Simpang Tiga Kampung Kalawi. Analisis hasil penelitian menunjukkan kinerja simpang untuk kondisi simpang tak bersinyal didapat jumlah arus total 2244 smp/jam, kapasitas (C) = 2287 smp/jam, derajat kejenuhan (DS) = 0,981, tundaan simpang = 19,822 detik/smp dan nilai peluang antrian = 76,365% - 38,634%. Untuk alternative penanganan solusi kemacetan pada Simpang Tiga Kampung Kalawi karena derajat kejenuhan sudah melebihi >0,8 dari ketentuan Manual Kapasitas Jalan Indonesia 1997 maka disarankan Simpang Tiga Kampung Kalawi perlu ditingkatkan pengaturannya menjadi simpang bersinyal pada Jalan raya M. Yunus waktu hijau (G) = 13 detik, Jalan raya Ampang waktu hijau (G) = 12 detik, pada Jalan raya Kalawi waktu hijau (G) = 11 detik.
Perancangan Dan Implementasi Robot Keseimbangan Beroda Dua Berbasis Mikrokontroler
Authors: Awal Hasri , Hendrik Billy , Arby Willya
Published: August 2023

In today's modern world, there are many scientists and resources created and developed by people to facilitate their work. Be it in the field of Industry, Medical, to the world of Education. One example of scientists and renewal of sources. This can be proven by the many technologies in the field of robotics that are deliberately made to help human work. If humans have five senses such as eyes to see, then the robot can be in the form of sensors such as photodiodes, ultrasonic sensors to hear or even a camera to see and record. The purpose of this research is to design a reliable control system so that the robot can stand upright. To be able to balance the standing position of the robot with two wheels, a good and reliable control method is needed to maintain the robot's position perpendicular to the earth's surface without requiring external controllers and applying Self-balancing Control.
Decentralized Environmental Regulation in a Model with Increasing-Returns-to-Scale
Authors: Kunce Mitch
Published: August 2023

Abstract

In economics, homothetic functions are generally used to represent production. Homogeneous production functions are a subset. A production function is homogeneous of degree α when all inputs are changed in the same proportion and resulting output changes by the αth power of the input change. Convention envisions homogeneity of degree 1, constant-returns-to-scale. Herein, we alter convention for increasing-returns-to-scale, α > 1. With aggregate increasing-returns-to-scale, symmetric regions, in a first-best Nash equilibrium, subsidize capital and overprotect the regional environment. Second-best fiscal structures are also examined.

JEL Classification numbers: H20, H71, H73
Keywords: Environmental federalism, Inter-jurisdictional competition, Increasing-returns-to-scale, Homothetic functions.
Pengaruh Return On Asset, Current Ratio, Debt To Equity Ratio Terhadap Harga Saham di Bursa Efek Indonesia
Authors: Sariyanto Sariyanto
Published: August 2023

Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh antara Current Ratio, Return On Asset, dan Debt To Equity Ratio Terhadap Harga Saham pada perusahaan sub sektor makanan dan minuman yang tercatat di Bursa Efek Indonesia (BEI) periode 2018-2022. Metode yang digunakan adalah kuantitatif, artinya peneliti akan mengkuantifikasi semua data yang diperoleh. Metode pengumpulan data dalam penelitian ini menggunakan metode dokumentasi. Hasil penelitian yang diperoleh dari uji parsial dengan tingkat signifikansi 0,05 diperoleh hasil: Current Ratio tidak berpengaruh signifikan terhadap harga saham dengan nilai probabilitas (0,798 > 0,05). Return On Aset berpengaruh signifikan terhadap harga saham dengan nilai probabilitas (0,002 < 0,05). Debt To Equity Ratio tidak berpengaruh signifikan terhadap harga saham dengan nilai probabilitas (0,508 > 0,05). Secara simultan CR, ROA, dan DER berpengaruh signifikan terhadap Harga Saham dengan nilai probabilitas (0,007 < 0,05). Nilai Adjusted R-squared sebesar 25,7% dipengaruhi oleh variabel independen diatas, sedangkan sisanya 74,3% dipengaruhi oleh faktor lain yang tidak dijelaskan dalam penelitian ini. Kesimpulan dari penelitian ini adalah Current Ratio dan Debt To Equity Ratio tidak berpengaruh signifikan terhadap Harga Saham. Return On Asset berpengaruh signifikan terhadap Harga Saham. Current Ratio, Return On Asset, serta Debt To Equity Ratio secara simultan berpengaruh signifikan terhadap Harga Saham.
Pengaruh Pengetahuan, Citra Perusahaan terhadap Kepercayaan dalam Keputusan Pembelian Produk Asuransi
Authors: Surya Indra , Naipospos Nova Yesyca
Published: August 2023

Jenis penelitian ini bersifat kuantitatif, yang menjadi tempat penelitian ini adalah kantor AIA Prudential di Medan. Penelitian ini bertujuan untuk menganalisis hasil kepercayaan, pengetahuan dan citra perusahaaan terhadap keputusan pembelian mengunakan korelasi secara parsial, determinasi dan regresi linier berganda. Metode pengumpulan data dalam penyusunan tugas akhir adalah metode observasi dan studi dokumentasi menggunakan analisis kuantitatif. Teknik analisa adalah regresi linier berganda menggunakan software IBM SPSS 21. Dalam penelitian ini data yang digunakan adalah data primer. Dari hasil uji koefisien korelasi secara parsial diperoleh hasil kepercayaan, pengetahuan dan citra perusahaan memiliki hubungan parsial yang signifikan terhadap keputusan pembelian. Kepercayaan, pengetahuan dan citra perusahaan berpengaruh terhadap keputusan pembelian produk asuransi AIA Prudential Cabang Medan secara simultan sebesar 62,9% sedangkan 37,1% dipengaruhi oleh faktor lain.
Testing Financial Statement Fraud: Perspective of the M-Score Model in Nigeria and South Africa
Authors: Ugbah Andrew A. , Kanene Kingsley C. , Ofor Nkechi T. , Gerald Anigbogu N.
Published: August 2023

In the past several years, financial statements fraud has cost market participants huge sum of loss and it has eroded market participants confidence in the audit financial report of organisations. This study therefore, examined the determinants of financial statement fraud in Nigeria and South Africa. The study specifically focus on firm size, leverage, board independence, institutional ownership, firm profitability and capital structure. The population of the study comprised 510 quoted non-financial companies in the Nigeria Stock Exchange and Johannesburg Stock Exchange for the periods 2012 to 2018. A sample size of 70 was selected using random sampling techniques. The data collected were analysed using descriptive statistics and robust least square regression analysis. It was observed from the descriptive statistics that there is presence of financial statement fraud reporting among the quoted non-financial companies in Nigeria and South Africa. The results revealed that firm size was statistically significant in Nigeria and South Africa, leverage was statistically insignificant in Nigeria and South Africa, board independence was statistically significant in Nigeria but insignificant in South Africa, institutional ownership was statistically significant in Nigeria and insignificant in South Africa, firm profitability was statistically significant in South Africa but insignificant in Nigeria while capital structure was statistically insignificant in Nigeria and South Africa. The study recommended that the results have direct implications for further improvement of firm size, board independence, institutional investors and capital structure.
Анализ средств и методов разработки программного обеспечения АРМ диспетчера
Authors: Кузнецов П. А. , Лифарь А. С.
Published: August 2023

В статье представлен анализ средств и методов разработки программного обеспечения автоматизированного рабочего места диспетчера для телеуправления электрическими тяговыми подстанциями. В работе дан краткий обзор современных цифровых микропроцессорных систем телемеханики, представлены временные характеристики для систем реального времени с удаленными диспетчерскими терминалами, к которым относятся время доступа и время ответа. Показано, что в общем случае необходим учет обработки запросов других пользователей (диспетчеров), если реализуется многопользовательский режим функционирования программного обеспечения автоматизированного рабочего места диспетчера. В работе технические средства диспетчерского пункта представлены персональным компьютером, интеллектуальным терминальным контроллером и УКВ трансивером. При разработке программного обеспечения необходимо реализовать протокол обмена с интеллектуальным терминальным контроллером через коммуникационный порт для передачи управляющих сигналов на тяговые подстанции и получения сообщений с удаленных комплексов. Состав структурных компонентов системы при выборе средств и методов разработки программного обеспечения включает среду разработки, СУБД и формат таблиц, COM-порт, протоколы обмена данными между компьютером диспетчера и интеллектуальным терминальным контроллером, графический интерфейс.
The Use of Nest Boxes in Malaysia: Design and the Potential for Research and In-situ Conservation of Birds
Authors: Muhammad Adam Mah Amera Natasha Mah , Leong Puan Chong , Zakaria Mohamed
Published: August 2023

Nest boxes have been used as artificial cavities for decades to attract cavity-nesting birds that rely on such structures to roost and breed. Nest boxes aid research efforts to understand the biology and behaviour of birds and may increase breeding success, thereby contributing to the conservation of a species. The type and dimension of nest boxes and the survey design used in the tropics vary, depending on the targeted species. This paper reviewed 30 published in-situ works using nest boxes and their survey design in Malaysia. Most studies were done on Barn Owls (Tyto alba javanica) (25), followed by hornbills (5), where they were conducted in oil palm plantations (50%), rice fields (20%), forest habitats (16.7%), urban landscapes (10%), and different habitat matrices (3.3%). Attempts to enhance/manage the local populations were the main research purpose. Unlike studies from other tropical countries, studies involving nest boxes in Malaysia are still in their infancy. This review suggests future research focus on forest species, especially those requiring immediate conservation attention, and delineate parameters highlighted in published works to counter literature inconsistency. Such research involving nest boxes may also be further expanded to the study and/or conserve other interconnected fauna species.
Molecular Characterisation of Partial Structural Genes of Fowl Adenovirus Serotype 8b UPMT1901 Field Strain Isolate Associated with the Inclusion Body Hepatitis in Malaysia’s Commercial Broiler Chickens
Authors: Azli Bahiyah , Salim Nur Farhana , Omar Abdul Rahman , Hair-Bejo Mohd , Mohamed Sohaimi Norfitriah , Mat Isa Nurulfiza
Published: August 2023

Fowl adenovirus (FAdV) is reported to pose a severe risk to the poultry industry, affecting food and nutrient security nationally and globally. FAdV is identified as the primary pathogen for inclusion body hepatitis (IBH) disease in avians during outbreaks in farms. Numerous interventions have been employed to reduce the chicken’s mortality rate in future outbreaks, such as local autogenous vaccine production that has yet to be successfully commercialised. Fibre and hexon protein are two out of the three major components of the adenoviral capsid, identified to contribute towards FAdV virulence. Hence, this study aims to determine the fibre and hexon gene molecular changes of a local isolate, FAdV UPMT1901, in Malaysia’s recent IBH outbreak and identify the evolutionary relationship with known FAdV strains. Propagation of FAdV UPMT1901 was performed in specific pathogen-free embryonated chicken prior to genomic extraction. The genes were amplified, and the retrieved nucleotide sequences were aligned with the published FAdV sequences. The phylogenetic tree analysis showed that UPMT1901 partial fibre and hexon genes are 99% similar to other known FAdV serotype 8b (FAdV-8b) species, especially the published Malaysian FAdV-8b isolates. Interestingly, the amino acid residue analysis further supported consistent residues amongst Malaysian isolates at fibre positions T176A, Q195H, D213E, S243T, A258V, F335Y, and F353V and hexon position T422M. These findings elucidate the structural proteins’ functional capacity and molecular diversity, specifically amongst Malaysian FAdV isolates and FAdV-8b, while contributing to global initiatives to establish biosecurity, such as a vaccine or antiviral production against future outbreaks.
Tropical Forests Stand Recovery 30-year After Selectively Logged in Peninsular Malaysia
Authors: Richard Aldrich , Mohamad Kassim Mohamad Roslan , Abd. Kudus Kamziah , Saleh Mohd. Nazre
Published: August 2023

This article analysed the 25–30 years of growth of dipterocarps forests that were logged under the Selective Management System (SMS) at three sites in Peninsular Malaysia to understand how management regimes affected forest stem density and basal area. The management regimes were (1) unlogged, (2) moderately logged forests that logged all dipterocarps ≥ 65 cm diameter at breast height (dbh) and all non-dipterocarps ≥ 60 cm dbh, and (3) intensely logged forests that logged all dipterocarps ≥ 50 cm dbh and non-dipterocarps ≥ 45 cm dbh. The intensely logged regime is similar to the SMS practices in Peninsular Malaysia. This result showed that one-year post-logging, there was no difference in the total stem density and basal area between forests logged according to the two management regimes. Forest stem density decreased over time in all management regimes, significantly greater in unlogged forests (-15.1 stems/ha/yr, confidence interval (CI): -16.9 to -13.3). This decline in stem density reflected that mortality exceeded recruitment in all management regimes. Despite the consistent decline of forest stem density, the basal area increased over time, and the rate of increase in the intensely logged forest (0.22 m2 /ha/yr, CI: 0.19 to 0.25) was significantly greater than the other management regimes. Our study showed that 30 years post-logging, the effect of selective logging remained evident. Both logged forest stem density and the basal area did not recover to that of unlogged forests, indicating the importance of enrichment planting and extending the cutting cycles beyond 30 years for the sustainability of dipterocarps forests.
Tereza e os rastros de memória
Authors: Pelisser Amanda , Pelisser Cristiano , Berreta Márcia dos Santos Ramos
Published: August 2023

A semente germinada fez florescer lembranças, produzir memórias e diversas narrativas e testemunhos a respeito de um passado que deixou marcas e rastros. Este artigo, nasce como fruto de uma dissertação de mestrado, a qual constituiu uma homenagem descritiva para minha avó Tereza Verônica Adamatti Isoppo (in memoriam). O estudo buscou compreender a história de vida presente na biografia dessa senhora e teve como objetivo principal recuperar pela memória da comunidade o papel biossocial e cultural da Dona Tereza. Além disso, a pesquisa permitiu promover um resgate dos saberes tradicionais em relação as plantas medicinais, ressaltando, por meio do esforço da memória, o misticismo presente na vida desta mulher. A pesquisa se desenvolveu por meio de um levantamento bibliográfico e entrevistas, bem como, por textos manuscritos pela própria Tereza. Os relatos das pessoas entrevistadas incidiram nos anos de 2021 e 2022, no Vale do Maquiné, litoral norte do estado do Rio Grande do Sul. Mediante a pesquisa realizada foi gerado o Produto do Mestrado profissional, que compõe um Livro em formato digital, representado por aquarelas de plantas medicinais ilustradas por meu irmão Cristiano Pelisser. As contribuições produzidas por este levantamento de cunho etnobotânico e etnoecológico possibilitou verificar que Tereza era detentora de um vasto conhecimento em relação ao uso de plantas medicinais, não obstante, criou laços marcantes na vida da sua localidade, trouxe às pessoas a cura pelas ervas e pelo acolhimento fraternal, sendo, portanto, para muitas pessoas uma inspiração no que diz respeito, aos enfrentamentos dos desafios da sociedade e da vida.
Potencialidades de um curso pré-universitário popular frente ao conhecimento pedagógico de conteúdo na formação inicial de docentes
Authors: Kavalek Débora Schmitt
Published: August 2023

Assumindo grande importância na trajetória acadêmica dos estudantes, a extensão universitária fortalece a relação e troca de saberes entre universidade e comunidade. O estudo em questão aborda as potencialidades de um curso pré-universitário popular em relação ao conhecimento pedagógico de conteúdo, formação inicial de docentes e diálogo entre a universidade e a sociedade. Objetiva discutir a extensão universitária a partir de um estudo de caso que aborda a experiência de curso pré-universitário realizado nas instituições de ensino estaduais onde funcionam os Colégios Universitários da Universidade Federal do Sul da Bahia, vinculada ao desafio do período pós-pandemia. Embasado em princípios da educação popular de Freire e em estudos de Lee Shulman e Tardif, este estudo explora as diferentes contribuições desta ação para os conhecimentos pedagógicos do conteúdo (formação docente) e a reinvenção da universidade, tendo compromisso com a transformação social e a democratização do conhecimento.
Soluble TNFR1 Levels in Type 2 Diabetes and its Association with Stages of Proteinuria
Authors: Lourdusamy Raghul , Gokulakrishnan Kuppan , Nilavan Ezhil , Balaji Nandagopal , Srinivasan Ramprasad
Published: August 2023

Aims: Early identification of at-risk individuals for diabetic nephropathy would help in preventing or delaying end-stage renal failure. We measured the levels of circulating soluble tumor necrosis factor receptor 1 (sTNFR1) in various stages of proteinuria (MAC) to determine the association of this marker with diabetic nephropathy. Materials and methods: The study was performed on 160 subjects, and a case-control methodology was employed. Type 2 diabetic subjects were recruited based on albuminuria and were grouped as (1) normoalbuminuria (NA); (2) microalbuminuria (MIC); (3) MAC; (4) normal glucose tolerance (NGT) subjects who served as healthy controls. sTNFR1 levels were measured by quantitative enzyme-linked immunosorbent assay (ELISA). Results: Soluble tumor necrosis factor receptor 1 (sTNFR1) levels were highest in the MAC group, followed by the microMAC group. The sTNFR1 levels were not statistically different between the NGT and NA groups. On regression models, sTNFR1 was associated with MIC [odds ratio (OR)— 6.491, 95% confidence interval (CI)—1.868–22.55] and MAC (OR per standard deviation—15.28; 95% CI—3.76–62.15; p < 0.001) even after controlling for all the possible confounding factors. Receiver operator curve (ROC) analysis revealed sTNFR1 cut-point of 1832 pg/mL had a C-statistic of 0.685 to discriminate MI from NA with 52% sensitivity. Whereas the sTNFR1 cut-point of 2050 pg/mL with a C-statistic of 0.8177 had 77% sensitivity for identifying MAC. Conclusion: Soluble tumor necrosis factor receptor 1 (sTNFR1) is significantly associated with MIC and MAC group in type 2 diabetes, and this suggests a potential early diagnostic biomarker role of sTNFR1 for MAC among Asian Indians.
Enfermagem como opção de profissão feminina na Universidade do Brasil
Authors: Ferreira Tábata Alves , Aperibense Pacita Geovana Gama de Sousa , Santos Fernanda Batista Oliveira , Peres Maria Angélica de Almeida
Published: August 2023

Objetivo: Analisar a motivação de mulheres para cursarem Enfermagem na Universidade do Brasil (UB) em meados do século XX. Métodos: estudo histórico-social, qualitativo, a partir de fontes orais de cinco ex-alunas do curso de Enfermagem da UB nas décadas de 1950 - 1960. A análise dos dados seguiu o método indutivo e triangulação de fontes, sendo subsidiada por estudos sobre a identidade profissional da enfermeira e a história das Escolas de Enfermagem no Brasil. Resultados: Critérios como “ser uma escola renomada”; “influência familiar”; e "processo de seleção" foram citados nos documentos. Observou-se influência familiar na escolha da profissão e o reconhecimento social da Escola Anna Nery (EAN), responsável pelo curso na UB. O advento do vestibular unificado, instaurado pela Lei 5.540/1968, aumentou ainda mais o interesse de moças pelo curso. Conclusão: Na escolha pela Enfermagem dessas ex-alunas existiu maior influência do renome das duas instituições (EEAN e UB) do que o desejo pela profissão. No período, a Enfermagem era uma opção favorável para moças interessadas em uma formação escolar de nível superior, ainda pouco alçada por mulheres à época. Assim, cursar Enfermagem na EEAN/UB significou para elas uma oportunidade de formação qualificada, de carreira e de independência financeira.
ORAL HEALTH PROMOTION AT SCHOOL
Authors: Nunes Maia Djanny
Published: August 2023

The Health at School Program presents itself as a concrete form of health promotion of extreme relevance for school assistance, facilitating the contact of the population with dental services. Objective: To expose the carrying out of health program activities at the Elementary School Cleudomir Begot in the region of Ananindeua- Pará. Methods: The actions involved students aged 05 and 13 years. Site visits were carried out to collect all data from the educational institution and planning activities. Audiovisual educational material was used on the ideal brushing technique; activity addressing the theme “diet” and guidance on oral hygiene. Experience report: The two moments in which the activities were carried out were extremely fruitful and the students who were the target audience of the actions, which added to the cooperation of the primary care team, resulted in success in the objectives of health promotion and protection. specific. Conclusion: Carrying out educational actions in the school environment through the health at school program is very important to improve the quality of dental health in the student population.
Innovación como impulsor de la competitividad, un reto para la región
Authors: Melara Cesar
Published: August 2023

No hay resúmenes disponibles.
Realidad Empresarial No. 15, 2023: 1-2.
Compras y entretenimiento
Authors: Ernst & Young Centroamerica
Published: August 2023

No hay resúmenes disponibles.
Realidad Empresarial No. 15, 2023: 3-10.
Avacopan (Tavneos)
Authors: CADTH
Published: August 2023

CADTH recommends that Tavneos not be reimbursed by public drug plans as adjunctive treatment for adults with severe active antineutrophil cytoplasmic autoantibody-associated vasculitis (ANCA-AV) (granulomatosis with polyangiitis [GPA] and microscopic polyangiitis [MPA]).

One clinical trial demonstrated that Tavneos in combination with ANCA-AV background therapy (including glucocorticoids and drugs that reduce immune system function) was as good as oral prednisone (60 mg dose reduced over 20 weeks) in combination with ANCA-AV background therapy for showing a reduction in disease symptoms at week 26 and was better than oral prednisone for maintaining symptom improvement at week 52. However, it was unclear if Tavneos offered a meaningful clinical benefit over other treatments used for ANCA-AV mainly because rituximab was not used as maintenance therapy in the trial, as is currently recommended by Canadian guidelines, and there is uncertainty around the clinical meaningfulness of the differences between the treatment groups for outcomes that assessed renal function, relapse, and Short Form [36] Health Survey version 2 (SF-36v2).

There was not enough evidence to conclude that Tavneos met patients’ needs for a treatment that reduces or eliminates the use of glucocorticoids and their side effects as well as improves their health-related quality of life (HRQoL).
Doğum Ağrısının Yönetiminde Kullanılan Masaj Teknikleri
Authors: SADE Gülüzar , ÖZKAN Hava
Published: August 2023

Doğum, kadınların yönetmek zorunda olduğu fizyolojik ve psikolojik bir süreçtir. Doğum ağrısı yeni bir bebeği dünyaya getirmeye aracılık ettiği için diğer ağrı türlerinden ayrılan benzersiz bir yaşam deneyimidir. Doğum ağrısı doğum sırasında oluşan duyusal uyaranların etkili olduğu, karmaşık, subjektif ve çok boyutlu bir yanıttır. Ayrıca doğum ağrısı kan basıncını, oksijen tüketimini ve ketokalamin düzeyini arttırdığı için uterusun kanlanmasını ve doğumun ilerlemesini engelleyebileceği için doğum sürecini olumsuz etkileyecektir. Bununla birlikte, doğum ağrısının yönetimi bu olumsuz etkileri en aza indirebilir.

Doğum ağrısının yönetimi farmakolojik ve farmakolojik olmayan yaklaşımları içermektedir.

Opioidler ve epidural analjezi doğum ağrısının yönetiminde kullanılan en popüler ve etkili farmakolojik yöntemlerdir, ancak doğumun ilerlemesini etkileyebilir, aletli doğum ve sezaryen riskini ve yenidoğan solunum depresyonu riskinin artırabilir. Fakat farmakolojik olmayan yaklaşımların kullanılması, doğum ağrısının ve doğum sırasında analjezik tüketiminin azaltılmasında etkilidir. Ayrıca, farmakolojik olmayan yaklaşımlar yan etkileri olmayan, anne memnuniyetini arttıran, diğer obstetrik ve neonatal sonuçlarda iyileşme ile ilişkili basit ve etkili tekniklerdir.

Masaj, vücudun yumuşak dokularının manipülasyonunu içermektedir. Genellikle gergin kasları gevşetmeye yardımcı olmak, bireyi yatıştırmak ve sakinleştirmek için kullanılmaktadır. Masaj, bireyin gevşemesine yardımcı olarak, ağrı yollarındaki duyusal iletimi engelleyerek veya kan akışını ve dokuların oksijenlenmesini iyileştirerek ağrıyı hafifletmeye yardımcı olmaktadır. Masaj terapisi derin doku masajı, İsveç masajı, nöromüsküler masaj veya shiatsu gibi belirli fiziksel teknikleri veya manuel terapiyi içerebildiği gibi basınç uygulayan ya da titreşim yaratan aletlerle yapılan mekanik masaj tekniklerini içermektedir. Doğumda uygulanan manuel masajlar algılanan doğum ağrısını azaltmakta, doğumun süresini kısaltmakta, doğum sonu maternal depresyon riskini azaltmakta ve doğum memnuniyetlerini arttırmaktadır. Doğumda mekanik masaj uygulamalarını araştıran sınırlı sayıda çalışma mevcut olsa da sonuçlar doğum ağrısını azaltmada etkili olduğunu göstermektedir. Doğum sırasında ağrıyı yönetmek için farklı kadınlara farklı masaj teknikleri uygulanmaktadır. Doğum sırasında uygulanacak masaj tekniğine, masaj yoğunluğuna, masaj süresine ve masaj bölgesine kadın karar vermelidir. Doğum ağrısının yönetiminde masaj kullanılacaksa kadının istediği teknikle masaj yapmak kadının doğuma uyumunu arttırarak algılanan ağrı seviyesini azaltmaktadır. Kadının tensel teması sevip sevmeme durumuna göre uygun masaj tekniği belirlenmeli ve masaj kadın için özelleştirilmelidir.
NUTRIGENÔMICA: INTOLERÂNCIAS ALIMENTARES, SINTOMAS TRICOLÓGICOS E A RELAÇÃO COM A ANEMIA ASSINTOMÁTICA
Authors: Souza Araújo Derneval , Silva Barbosa Flávia
Published: August 2023

Este artigo visa o entendimento da relação entre nutrição e alimentação, visto que, ao se alimentar, a pessoa pode não está se nutrindo adequadamente por meio da absorção e metabolização correta dos nutrientes, existem fatores exógenos que interferem no metabolismo, exemplo os alérgenos de resposta exagerada e imediata do sistema imune a componentes da dieta, cujas manifestações são variáveis é classificada como alergia alimentar. Ao contrário das alergias as intolerâncias alimentares são reações adversas aos alimentos que desencadeiam sintomas às vezes tardios após anos de ingestão, entre os sintomas mais frequentes são desordens capilares, dor de estômago, inchaço, gases / flatulência, diarreia, síndrome do intestino irritável (SII), erupções cutâneas, urticária (urticária), úlceras bucais recorrentes ou dores de cabeça. Na maioria das vezes as intolerâncias estão relacionadas aos (CBAs) compostos bioativos dos alimentos, estes, além dos nutrientes podem conter antinutrientes, que são produtos do metabolismo secundário vegetal, naturalmente encontrados em animais e em muitos alimentos vegetais, aos quais fazem parte os glucosinolatos, lectinas, oxalatos, fitatos, saponinas, taninos entre outros capazes de desencadear distúrbios e disfunções no organismo, tais como deficiências nutricionais, tendo em vista que, alimentos contendo antinutrientes como os fitatos potencializam a deficiência de ferro e cálcio. A ingestão de nutrientes na dieta é um fator ambiental capaz de classificar a ingestão alimentar entre diferentes indivíduos e exercem função de variação dos polimorfismos genéticos. Então, entender a nutrigenética e nutrigenômica proporciona ao nutricionista uma avaliação específica para cada pessoa e problema de saúde, beleza e bem-estar. Atualmente, conhece-se uma variedade de alimentos com propriedades funcionais, ou seja, alimentos que além das funções nutricionais básicas produzem efeitos benéficos à saúde. Os problemas decorrentes de carências nutricionais em qualidade e quantidade podem levar a um quadro inicial de anemias assintomáticas, causando problemas capilares diversos.
A nyugati jog szellemisége és Az elkülönítő: a nyugati jog nyelve mint nyelvi lázadás Hajnóczy Péter prózájában
Authors: Fekete Balázs
Published: August 2023

A tanulmány a hazai jog és irodalom kutatások „nagytamási” programját követve amellett érvel, hogy Hajnóczy Péter Az elkülönítő című művét érdemes a jogi nyelv írói használata szempontjából is megközelíteni. Az elkülönítőben a szerző a „nyugati jog” jogvédelem-fókuszú nyelvét használja – ami már önmagában is izgalmas a korszak marxizmus-leninizmus által uralt jogi kultúrájában – és ez egyértelműen nyelvi lázadásnak tekinthető a korszak viszonyai között. Ezt a következtetést megerősíti, ha Hajnóczy jogfókuszú nyelvhasználatát a szocializmussal szemben kritikus más szerzők, például Kertész Imre vagy Hertha Müller műveivel vetjük össze. Másrészt, ez a megközelítés segít Hajnóczy utolsó rövid írásainak – melyeket az irodalomtudomány kevésbé értékel – új kontextusba helyezésében is, ebből a szempontból ugyanis letagadhatatlan kapcsolat fűzi ezeket Az elkülönítőhöz, hiszen ugyanúgy a szocialista Magyarország joghiányból fakadó abszurditására mutatnak rá.
ABORDAGENS CIRÚRGICAS MINIMAMENTE INVASIVAS EM CIRURGIA CARDÍACA: RESULTADOS E COMPLICAÇÕES
Authors: Zbierski Millena de Lima , Silva Teynan Antônio Nunes da , Bom Junior Luiz Cesar , Guterres Maria Eduarda Mendes , Silva Fábio Augusto Oliveira do Carmo , Costa Caio Dafnis Faria da , Martins João Marcelo Reis , Marrone Vittoria Giulia da Silva , Hilário Thalita de Oliveira , Moreira Thais Gomes
Published: August 2023

O resumo deste artigo sobre "Abordagens Cirúrgicas Minimamente Invasivas em Cirurgia Cardíaca: Resultados e Complicações" apresenta uma síntese dos principais aspectos abordados na pesquisa. O estudo examinou os resultados clínicos e funcionais, bem como as complicações associadas às abordagens cirúrgicas minimamente invasivas em cirurgia cardíaca, comparando-as com as técnicas cirúrgicas tradicionais. Foram analisados os desfechos positivos dessas abordagens, evidenciando a melhoria da qualidade de vida, recuperação mais rápida e aprimoramento da função cardíaca nos pacientes submetidos a esses procedimentos. No entanto, as complicações intraoperatórias e pós-operatórias também foram examinadas, destacando os desafios e riscos associados a essas técnicas avançadas. A comparação entre as abordagens minimamente invasivas e as técnicas tradicionais revelou vantagens potenciais, embora tenha sido enfatizada a importância da avaliação individualizada para a escolha da abordagem mais adequada, levando em consideração a complexidade do caso e as características do paciente. Este estudo contribui para o entendimento abrangente das implicações das abordagens cirúrgicas minimamente invasivas em cirurgia cardíaca. As considerações finais enfatizam a necessidade contínua de pesquisa e aprimoramento dessas técnicas, além da importância da formação especializada dos cirurgiões para garantir o sucesso e a segurança dos procedimentos. Em resumo, esta pesquisa oferece insights valiosos para a prática clínica, destacando os benefícios e os desafios das abordagens minimamente invasivas em cirurgia cardíaca, com o objetivo de aprimorar os cuidados de saúde cardiovascular e a qualidade de vida dos pacientes submetidos a essas intervenções.
The bottom mixed layer depth as an indicator of subsurface Chlorophyll a distribution
Authors: Zampollo Arianna , Cornulier Thomas , O'Hara Murray Rory , Tweddle Jacqueline Fiona , Dunning James , Scott Beth E.
Published: August 2023

Abstract. Primary production dynamics are strongly associated with vertical density
profiles in shelf waters. Variations in the vertical structure of the
pycnocline in stratified shelf waters are likely to affect nutrient fluxes and
hence the vertical distribution and production rate of phytoplankton. To
understand the effects of physical changes on primary production,
identifying the linkage between water column density and Chlorophyll a
(Chl a) profiles is essential. Here, the vertical distributions of density
features describing three different portions of the pycnocline (the top,
centre, and bottom) were compared to the vertical distribution of
Chl a to provide auxiliary variables to estimate Chl a in shelf waters. The
proximity of density features with deep Chl a maximum (DCM) was tested using
the Spearman correlation, linear regression, and a major axis regression over 15
years in a shelf sea region (the northern North Sea) that exhibits
stratified water columns. Out of 1237 observations, 78 % reported DCM
above the bottom mixed layer depth (BMLD: depth between the bottom of the
pycnocline and the mixed layer underneath) with an average distance of 2.74 ± 5.21 m from each other. BMLD acts as a vertical boundary above which
subsurface Chl a maxima are mostly found in shelf seas (depth ≤ 115 m).
Overall, DCMs were correlated with the halfway pycnocline depth (HPD) (ρS = 0.56) which, combined with BMLD, were better predictors of the locations
of DCMs than surface mixed layer indicators and the maximum squared buoyancy
frequency. These results suggest a significant contribution of deep mixing
processes in defining the vertical distribution of subsurface production in
stratified waters and indicate BMLD as a potential indicator of the Chl a
spatiotemporal variability in shelf seas. An analytical approach integrating
the threshold and the maximum angle method is proposed to extrapolate BMLD,
the surface mixed layer, and DCM from in situ vertical samples.
DINOSTRAT version 2.0-GTS2020
Authors: Bijl Peter K.
Published: August 2023

Abstract. DINOSTRAT version 2.0-GTS2020 is now available (Bijl et al., 2023a; http://dx.doi.org/10.5281/zenodo.7791273). This version updates DINOSTRAT to the Geologic Time Scale 2020, and new publications are added into the database. The resulting database now contains over 9,450 entries from 209 sites. This update has not led to major and profound changes in the conclusions made previously. DINOSTRAT allows full presentation of first and last stratigraphic occurrences of dinocyst (sub-) families, as well as the evolutionary turnover throughout geologic history, as a reliable representation of dinoflagellate evolution. Although the picture of dinoflagellate evolution from DINOSTRAT is broadly consistent with that in previous publications, the underlying data is with DINOSTRAT openly available, reproducible, and up to date. This release of DINOSTRAT allows calibration of stratigraphic records to the Geologic Time Scale 2020 using dinoflagellate cysts as biostratigraphic tool.
A gridded air quality forecast through fusing site-available machine learning predictions from RFSML v1.0 and chemical transport model results from GEOS-Chem v13.1.0 using the ensemble Kalman filter
Authors: Fang Li , Jin Jianbing , Segers Arjo , Liao Hong , Li Ke , Xu Bufan , Han Wei , Pang Mijie , Lin Hai Xiang
Published: August 2023

Abstract. Statistical methods, particularly machine learning models, have gained significant popularity in air quality predictions. These prediction models are commonly trained using the historical measurement datasets independently collected at the environmental monitoring stations and their operational forecasts in advance using inputs of the real-time ambient pollutant observations. Therefore, these high-quality machine learning models only provide site-available predictions and cannot solely be used as the operational forecast. In contrast, deterministic chemical transport models (CTMs), which simulate the full life cycles of air pollutants, provide predictions that are continuous in the 3D field. Despite their benefits, CTM predictions are typically biased, particularly on a fine scale, owing to the complex error sources due to the emission, transport, and removal of pollutants. In this study, we proposed a fusion of site-available machine learning prediction, which is from our regional feature selection-based machine learning model (RFSML v1.0), and a CTM prediction. Compared to the normal pure machine learning model, the fusion system provides a gridded prediction with relatively high accuracy. The prediction fusion was conducted using the Bayesian-theory-based ensemble Kalman filter (EnKF). Background error covariance was an essential part in the assimilation process. Ensemble CTM predictions driven by the perturbed emission inventories were initially used for representing their spatial covariance statistics, which could resolve the main part of the CTM error. In addition, a covariance inflation algorithm was designed to amplify the ensemble perturbations to account for other model errors next to the uncertainty in emission inputs. Model evaluation tests were conducted based on independent measurements. Our EnKF-based prediction fusion presented superior performance compared to the pure CTM. Moreover, covariance inflation further enhanced the fused prediction, particularly in cases of severe underestimation.
Sensitivity of the WRF-Chem v4.4 ozone, formaldehyde, and precursor simulations to multiple bottom-up emission inventories over East Asia during the KORUS-AQ 2016 field campaign
Authors: Kim Kyoung-Min , Kim Si-Wan , Seo Seunghwan , Blake Donald R. , Cho Seogju , Crawford James H. , Emmons Louisa , Fried Alan , Herman Jay R. , Hong Jinkyu , Jung Jinsang , Pfister Gabriele , Weinheimer Andrew J. , Woo Jung-Hun , Zhang Qiang
Published: August 2023

Abstract. In this study, the WRF-Chem v4.4 model was utilized to evaluate three bottom-up emission inventories (EDGAR-HTAP v2, v3, and KORUS v5) using surface and aircraft data in East Asia during the Korea-United States Air Quality (KORUS-AQ) campaign period in 2016. All emission inventories were found to reproduce the diurnal variations of O3 and NO2 as compared to the surface monitor data. However, the spatial distributions of the daily maximum 8-hour average (MDA8) O3 in the model do not completely align with the observations. The model MDA8 O3 had a negative (positive) bias north (south) of 30° N over China. All simulations underestimated the observed CO by 50–60 % over China and South Korea. In the Seoul Metropolitan Area (SMA), EDGAR-HTAP v2, v3, and KORUS v5 simulated the vertical shapes and diurnal patterns of O3 and other precursors effectively, but the model underestimated the observed O3, CO and HCHO concentrations. Notably, the model aromatic VOCs were significantly underestimated with the three bottom-up emission inventories, although the KORUS v5 shows improvements. The model isoprene estimations had a positive bias relative to the observations, suggesting that the Model of Emissions of Gases and Aerosols from Nature (MEGAN) version 2.04 overestimated isoprene emissions. Additional model simulations were conducted by doubling CO and VOC emissions over China and South Korea to investigate the causes of the model O3 biases and the effects of the long-range transport on the O3 over South Korea. The doubled CO and VOC emission simulations improved the model O3 simulations for the local emission dominant case, but led to the model O3 overestimations for the transport dominant case, which emphasizes the need for accurate representations of the local VOC emissions over South Korea.
Variability of manometric sea level from reanalyses and observation-based products over the Arctic and North Atlantic Oceans and the Mediterranean Sea
Authors: Storto Andrea , Chierici Giulia , Pfeffer Julia , Barnoud Anne , Bourdalle-Badie Romain , Blazquez Alejandro , Cavaliere Davide , Coupry Benjamin , Drevillon Marie , Fourest Sebastien , Larnicol Gilles , Yang Chunxue
Published: August 2023

Abstract. Regional variations of the mass component of sea level (manometric sea level) are intimately linked with the changes in the water cycle, volume transports, and inter-basin exchanges. Here, we investigate the consistency at the regional level of the manometric sea level from the Copernicus Marine Service global reanalyses and compare with observation-based products, deduced from either gravimetry (GRACE missions) or altimetry and in-situ ocean observations (sea level budget approach, SLB), for some climate-relevant diagnostics such as interannual variability, trends, and seasonal amplitude. The analysis is performed for three basins (Mediterranean Sea; Arctic, and North Atlantic Oceans), and indicates very different characteristics across the three. The Mediterranean Sea exhibits the largest interannual variability, the Arctic Ocean the most pronounced seasonal cycle, and the North Atlantic a nearly linear increase that is well explained by global barystatic sea level variations. The three datasets show significant consistency at both the subannual and the interannual time scales, although differences in linear trends are sometimes significant (e.g., GRACE overestimates the trend in the Arctic and underestimates it in the Mediterranean Sea, compared to the other products). Furthermore, GRACE and GREP prove mutually more consistent than with respect to the SLB in some cases, i.e., in the Arctic Ocean (all scales) and in the Mediterranean Sea (subannual scale). Finally, we analyze the main modes of variability for the selected ocean basins and link them with large-scale modes of climate variability; the North Pacific Gyre Oscillation, the Arctic Oscillation, and the Atlantic Multidecadal Oscillation are proven to be the most influential modes for the North Atlantic Ocean, Mediterranean Sea, and Arctic Ocean manometric sea level, respectively.
Monitoring the record-breaking wave event in Melilla harbour (SW Mediterranean Sea)
Authors: Lorente Pablo , de Alfonso Marta , Gil Pilar , Manzano Fernando , Matulka Anna Magdalena , Pérez-Gómez Begoña , Pérez-Rubio Susana , Ruiz M. Isabel
Published: August 2023

Abstract. The accurate monitoring and understanding of violent weather-related hazards are decisive to adopt prevention strategies and enhance the socio-ecological resilience of coastal communities. A record-breaking wave storm hit Melilla harbour (Alborán Sea) during the 4th–5th of April 2022. The maximum significant wave height (SWH) and mean period registered by a coastal buoy were 7.32 m and 9.42 s, respectively, beating previous historical records. Port decision-makers precautionary suspended maritime operations for security reasons due to the prevailing harsh weather, the overtopping of breakwaters and the presence of extreme harbour agitation (1.41 m) and sea level oscillations dominated by the infragravity band. In this work, the record-breaking event was analysed and retrospectively compared against six previous extreme wave episodes. All of them were connected with similar large-scale atmospheric driving forces: a dipole-like sea level pressure (SLP) pattern, characterised by two adjacent (northern) high and (southern) low pressure systems, which induced strong easterly winds over the entire Alborán Sea. The 2022 record-breaking event differed from the rest in the much stronger SLP gradient (2 Pa·km-1). The common atmospheric configuration seems to predominantly feature during the same stage of the year, a 6-week period between late February and early April, contrasting with NW Spanish harbours where the storm season typically spans from November to March. Finally, a 30-year (1993–2022) regional wave reanalysis product was used to characterise the intra-annual variability of the 99th percentile (P99) of SWH along the Alborán Sea and identify the existence of trends. Results revealed that the intensity of extreme wave events impacting Melilla harbour have increased for April while observed trends indicate a significant decrease of the P99 of SWH for June and October.