bluuebunny/crossref_metadata_2025 huggingface dataset:
Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer
Authors: Lin Peng-Chan , Yeh Yu-Min , Wu Pei-Ying , Hsu Keng-Fu , Chang Jang-Yang , Shen Meng-Ru
Published: March 2019

Although somatic mutations are the main cause of cancer, underlying germline alterations may affect cancer outcome. There is little information on comprehensive analysis of germline genome sequencing for cancer healthcare strategy. Here we studied the implication of germline cancer-associated variants on cancer counselling and therapeutic strategies by germline whole genome and tumor targeted sequencing. Fifty-five gynecological and 104 colorectal cancer (CRC) patients were enrolled. We identified 22 germline pathogenic variants in 16 cancer-associated genes. Most of them are involved in DNA repair signaling, including MLH1, BRCA1/2, MUTYH, ATM, PMS2, MSH6, BAP1, and FANCA. About 6% of cancer patients presented the secondary findings of germline variants with non-oncogenic impact, mainly on the cardiovascular system which should be carefully monitored during chemotherapy. CRC patients carrying germline susceptibility variants had better disease-free survival than those without variants. Importantly, in the CRC model, the underlying germline alterations mold the tumor somatic alteration landscape. NOTCH1 mutation was the most common somatic mutation in recurrent CRC, implying a potential therapeutic target in adjuvant setting. In conclusion, both tumor genome and germline sequence data have to be analyzed to have a more complete picture of the overall genetic foundation of cancer.
Photoelasticity-based evaluation of cellular contractile force for phenotypic discrimination of vascular smooth muscle cells
Authors: Sugita Shukei , Mizutani Eri , Hozaki Masatoshi , Nakamura Masanori , Matsumoto Takeo
Published: March 2019

Vascular smooth muscle cells (VSMCs) have two distinct phenotypes: contractile and synthetic. The major difference between these phenotypes lies in the magnitude of the contractile force produced by the cell. Although traction force microscopy (TFM) is often used to evaluate cellular contractile force, this method requires complex preprocessing and a sufficiently compliant substrate. To evaluate the contractile force and the phenotype of living VSMCs with minimal effort and in a manner independent of the substrate stiffness, we propose a photoelasticity-based method using retardation, which is related to the difference between the first and second principal stresses and their orientation. The results demonstrate that actin filaments co-localize with areas of high retardation in cells, indicating that the retardation of VSMCs is promoted by actin filaments. The retardation of cells treated with calyculin A and Y-27632 tended to be larger and smaller, respectively, than that of control cells. Cell traction force significantly correlates with total cell retardation (r2 = 0.38). The retardation of contractile VSMCs (passage 2) was significantly higher than that of synthetic VSMCs (passage 12). These results indicate that cell retardation can be used to assess cell contractile force and, thus, determine the phenotype of VSMCs.
Prognostic Significance of Mean Platelet Volume on Local Advanced Non-Small Cell Lung Cancer Managed with Chemoradiotherapy
Authors: Sakin Abdullah , Secmeler Saban , Arici Serdar , Geredeli Caglayan , Yasar Nurgul , Demir Cumhur , Aksaray Ferdi , Cihan Sener
Published: March 2019

Mean platelet volume (MPV), the most commonly used measure of platelet size, and is altered in patients with malignancies. The aim of this study was to investigate the effect of MPV on overall survival (OS) of patients with locally advanced (Stage IIIA/B) inoperable non-small cell lung cancer (NSCLC). This retrospective study included patients who received concomitant chemoradiotherapy (CCRT) with cisplatin + etoposide regimen due to locally advanced stage IIIA/B NSCLC. The study included a total of 115 cases, consisting of 110 (95.7%) male and 5 (4.2%) female patients. The mean age of the patients was 61.3 ± 10.4 (22–82) years. ROC curve generated by MPV for OS yielded an AUC of 0.746 (95% CI 0.659–0.833), (p < 0.001). MPV was detected as >9 fL with a sensitivity of 74.4% and a specificity of 72.0%. In patients with stage IIIA, median OS was 45.0 months (95% CI 17.3–74.1) and 21 months (95% CI 10.6–31.3) in groups with MPV > 9.0 fL and ≤9.0 fL, respectively (p = 0.013). In patients with stage IIIB, median OS was 44.0 months (95% CI 13.8–60.6) and 16 months (95% CI 9.5–22.4) in groups with MPV > 9.0 fL and ≤9.0 fL, respectively (p = 0.036). ECOG performance score, total platelet count, and MPV were found as the most significant independent factors affecting survival (p < 0.001, p = 0.008, and, p = 0.034, respectively). In this study, we showed that decreased pre-treatment MPV was an independent risk factor for survival in NSCLC patients who were administered CCRT. As part of routine complete blood count panel, MPV may represent one of the easiest measuring tools as an independent prognostic marker for survival in locally advanced NSCLC.
Induction of tumor-specific CTL responses using the C-terminal fragment of Viral protein R as cell penetrating peptide
Authors: Gross D. A. , Leborgne C. , Chappert P. , Masurier C. , Leboeuf M. , Monteilhet V. , Boutin S. , Lemonnier F. A. , Davoust J. , Kichler A.
Published: March 2019

The discovery of tumor-associated antigens recognized by T lymphocytes opens the possibility of vaccinating cancer patients with defined antigens. However, one of the major limitation of peptide-based vaccines is the low immunogenicity of antigenic peptides. Interestingly, if these epitopes are directly delivered into the cytoplasm of antigen presenting cells, they can be efficiently presented via the direct MHC class I presentation pathway. To improve antigen entry, one promising approach is the use of cell penetrating peptides (CPPs). However, most studies use a covalent binding of the CPP with the antigen. In the present study, we focused on the C-terminal domain of Vpr which was previously demonstrated to efficiently deliver plasmid DNA into cells. We provide evidence that the peptides Vpr55-91 and Vpr55-82 possess the capacity of delivering proteins and epitopes into cell lines as well as into human primary dendritic cells, without the necessicity for a chemical linkage. Moreover, immunization of HLA-A2 transgenic mice with Vpr55-91 as the sole adjuvant is able to induce antigen-specific cytotoxic T lymphocytes against multiple tumor epitopes.
Determinants of high platelet reactivity in patients with acute coronary syndromes treated with ticagrelor
Authors: Adamski Piotr , Buszko Katarzyna , Sikora Joanna , Niezgoda Piotr , Fabiszak Tomasz , Ostrowska Małgorzata , Barańska Malwina , Karczmarska-Wódzka Aleksandra , Navarese Eliano Pio , Kubica Jacek
Published: March 2019

High platelet reactivity (HPR) is a risk factor for stent thrombosis, a potentially lethal complication of percutaneous coronary intervention. HPR is also associated with increased risk of myocardial infarction and death in invasively-treated patients with acute coronary syndrome (ACS). HPR occurs even in ACS patients treated with ticagrelor, a state-of-the-art antiplatelet agent, especially during the first hours of treatment. Patient-level pharmacodynamic data obtained from 102 ACS subjects enrolled in two prospective, pharmacodynamic trials were analysed in order to identify clinical features related with increased odds of on-ticagrelor HPR during the first two hours after ticagrelor loading dose in ACS patients. Presence of ST-segment elevation myocardial infarction (versus non-ST-segment elevation ACS) and morphine co-administration were the strongest predictors of HPR at 1 and 2 hours after ticagrelor loading dose according to linear regression analyses, multiple backward stepwise logistic regression analyses and generalized estimating equation model. By pinpointing simple to recognize clinical features, the results of this study facilitate identification of ACS patients who have the highest odds of HPR during the initial phase of treatment with ticagrelor, and who could potentially benefit from alternative treatment strategies.
Similarities, variations, and evolution of cytochrome P450s in Streptomyces versus Mycobacterium
Authors: Senate Louisa Moshoeshoe , Tjatji Martin Phalane , Pillay Kayla , Chen Wanping , Zondo Ntokozo Minenhle , Syed Puleng Rosinah , Mnguni Fanele Cabangile , Chiliza Zinhle Edith , Bamal Hans Denis , Karpoormath Rajshekhar , Khoza Thandeka , Mashele Samson Sitheni , Blackburn Jonathan Michael , Yu Jae-Hyuk , Nelson David R. , Syed Khajamohiddin
Published: March 2019

Cytochrome P450 monooxygenases (P450s) found in all domains of life are known for their catalytic versatility and stereo- and regio-specific activity. While the impact of lifestyle on P450 evolution was reported in many eukaryotes, this remains to be addressed in bacteria. In this report, Streptomyces and Mycobacterium, belonging to the phylum Actinobacteria, were studied owing to their contrasting lifestyles and impacts on human. Analyses of all P450s and those predicted to be associated with secondary metabolism have revealed that different lifestyles have affected the evolution of P450s in these bacterial genera. We have found that while species in both genera have essentially the same number of P450s in the genome, Streptomyces P450s are much more diverse than those of Mycobacterium. Moreover, despite both belonging to Actinobacteria, only 21 P450 families were common, and 123 and 56 families were found to be unique to Streptomyces and Mycobacterium, respectively. The presence of a large and diverse number of P450s in Streptomyces secondary metabolism contributes to antibiotic diversity, helping to secure the niche. Conversely, based on the currently available functional data, types of secondary metabolic pathways and associated P450s, mycobacterial P450s seem to play a role in utilization or synthesis of lipids.
Intrinsic timescales of sensory integration for motion perception
Authors: Choi Woochul , Paik Se-Bum
Published: March 2019

A subject-specific process of perceptual decision making is of importance to how the brain translates its interpretation of sensory information into behavior. In particular, a number of studies reported substantial variation across the observers’ decision behavior, which may reflect different profiles of evidence accumulated by each individual. However, a detailed profile of perceptual integration has not yet been verified from human behavioral data. To address the issue, we precisely measured the time course of sensory integration, as the “sensory integration kernel” of subjects, using a coherence-varying motion discrimination task. We found that each subject has a distinct profile of sensory integration. We observed that kernel size (maximum sensory integration interval) is consistent within subjects, independent of external stimuli conditions. The observed kernel could accurately predict subject-specific perceptual behaviors and explain the inter-individual variation of observed behaviors. Surprisingly, the performance of most subjects did not improve in proportion to increased duration of the stimulus, but was maximized when the stimulus duration matched their kernel size. We also found that the observed kernel size was strongly correlated with the subject-specific perceptual characteristics for illusory motion. Our results suggest that perceptual decisions arise from intrinsic decision dynamics, and on individual timescales of sensory integration.
Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome
Authors: Maidana P. , Fritzler A. , Mocarbel Y. , Perez Lana M. B. , González D. , Rosales M. , González de Chazal F. , Sternberg K. , Lamas Majek E. , Mallea-Gil S. , Genovesi E. , Pelayo M. , Fabre B. , Mesch V.
Published: March 2019

Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabolic alterations and inflammation markers in PCOS. In 73 patients and 33 controls, 25-hydroxyvitamin D (25-OH-D), total and bioavailable testosterone (TT and bioT), androstenedione (A4), SHBG, cortisol, insulin, and C-reactive protein (hs-CRP) were determined; HOMA and lipid accumulation product (LAP) index were calculated. All parameters were higher in patients than in controls, except for SHBG and 25-OH-D which were lower. Binary regression analysis showed that differences in TT, bioT, A4, insulin and HOMA were independent of body mass index and waist circumference but SHBG, hs-CRP, LAP and 25-OH-D were related to body weight and fat distribution. Binary logistic regression analysis showed that cortisol and 25-OH-D could be associated to PCOS development. Correlations found between LAP and insulin, HOMA and hs-CRP confirm it is a good indicator of metabolic complications. Vitamin D and cortisol association to PCOS development justifies future research to understand the role of vitamin D in PCOS and analyze patient’s perinatal history and its possible relationship with hyperactivation of adrenal axis in adult life.
First Evidence for Mechanism of Inverse Ripening from In-situ TEM and Phase-Field Study of δ′ Precipitation in an Al-Li Alloy
Authors: Park Jiwon , Kamachali Reza Darvishi , Kim Sung-Dae , Kim Su-Hyeon , Oh Chang-Seok , Schwarze Christian , Steinbach Ingo
Published: March 2019

In-situ TEM investigation of aging response in an Al–7.8 at.% Li was performed at 200 °C up to 13 hours. Semi-spherical δ′ precipitates growing up to an average radius of 7.5 nm were observed. The size and number of individual precipitates were recorded over time and compared to large-scale phase-field simulations without and with a chemo-mechanical coupling effect, that is, concentration dependence of the elastic constants of the matrix solid solution phase. This type of coupling was recently reported in theoretical studies leading to an inverse ripening process where smaller precipitates grew at the expense of larger ones. Considering this chemo-mechanical coupling effect, the temporal evolution of number density, average radius, and size distribution of the precipitates observed in the in-situ experiment were explained. The results indicate that the mechanism of inverse ripening can be active in this case. Formation of dislocations and precipitate-free zones are discussed as possible disturbances to the chemo-mechanical coupling effect and consequent inverse ripening process.
Predictors of outcomes in patients on peritoneal dialysis: A 2-year nationwide cohort study
Authors: Abe Masanori , Hamano Takayuki , Hoshino Junichi , Wada Atsushi , Nakai Shigeru , Hanafusa Norio , Masakane Ikuto , Nitta Kosaku , Nakamoto Hidetomo
Published: March 2019

There has been no nationwide study of prognostic factors and outcomes in patients on peritoneal dialysis (PD) in Japan. We conducted a cohort study using data from the nationwide registry of the Japanese Society for Dialysis Therapy. We followed 8,954 prevalent PD patients for 2 years, 2014–2015. Cox proportional hazards regression analysis was used to determine factors that were independently associated with patient survival. Survival rates were compared between patients with and without diabetes after adjusting for potential confounders. During the 2-year study period, 893 (10.0%) of 8,954 patients died, 148 (1.6%) underwent kidney transplantation, and 2,637 (29.4%) were switched to hemodialysis; 5,276 (58.9%) patients were alive at the end of the study period. After multivariate adjustment, older age, longer duration of dialysis, presence of diabetes, cardiovascular comorbidity, use of 2.5% glucose dialysate, higher C-reactive protein and phosphate levels, and a lower serum albumin level were independently associated with increased hazard ratios for all-cause mortality. A combination of PD and hemodialysis was associated with a lower mortality rate. The new-onset cardiovascular event rate was significantly higher in the diabetes group than in the non-diabetes group (P < 0.0001). After adjusting for all variables, the hazard ratio was 1.509 (95% confidence interval 1.029–2.189, P = 0.036) in the diabetes group. Diabetes, older age, longer duration of dialysis, cardiovascular comorbidity, and inflammation were predictors of mortality in patients on PD.
Wireless wide-range pressure sensor based on graphene/PDMS sponge for tactile monitoring
Authors: Kou Hairong , Zhang Lei , Tan Qiulin , Liu Guanyu , Dong Helei , Zhang Wendong , Xiong Jijun
Published: March 2019

We propose a flexible wireless pressure sensor, which uses a graphene/polydimethylsiloxane (GR/PDMS) sponge as the dielectric layer. The sponge is sandwiched between two surfaces of a folded flexible printed circuit with patterned Cu as the antenna and electrode. By adjusting graphene and NH4HCO3 concentrations, a composite with 20% concentration of NH4HCO3 and 2% concentration of graphene as the dielectric layer is obtained, which exhibits high sensitivity (2.2 MHz/kPa), wide operating range (0–500 kPa), rapid response time (~7 ms), low detection limit (5 Pa), and good stability, recoverability, and repeatability. In addition, the sensor is sensitive to finger bending and facial muscle movements for smile and frown, that are transmitted using wireless electromagnetic coupling; therefore, it has potential for a wide range of applications such as intelligent robots, bionic-electronic skin and wearable electronic devices.
The Association of Body Size, Shape and Composition with Vertebral Size in Midlife – The Northern Finland Birth Cohort 1966 Study
Authors: Oura Petteri , Nurkkala Marjukka , Auvinen Juha , Niinimäki Jaakko , Karppinen Jaro , Junno Juho-Antti
Published: March 2019

Small vertebral size increases the risk of osteoporotic vertebral fractures. Obese individuals have larger vertebral size and potentially lower fracture risk than lean individuals, but scarce data exist on the association between vertebral size and anthropometric measures beyond height, weight, and body mass index (BMI). Here, we evaluated several anthropometric measures (height, weight, BMI, waist circumference, hip circumference, waist-to-hip ratio [WHR], waist-to-height ratio [WHtR], fat mass [FM], lean body mass [LBM], percentage FM [%FM], percentage LBM [%LBM]) as predictors of vertebral cross-sectional area (CSA). We used a representative sample from the Northern Finland Birth Cohort 1966 (n = 1087), with anthropometric measurements from the ages of 31 and 46, bioimpedance analysis from the age of 46, and lumbar magnetic resonance imaging from the age of 46 years. In our data, height and LBM correlated most strongly with vertebral CSA among both sexes (0.469 ≤ r ≤ 0.514), while WHR, WHtR, %FM, and %LBM had the weakest correlations with vertebral CSA (|r| ≤ 0.114). We conclude that height and LBM have the highest, yet only moderate correlations with vertebral size. High absolute LBM, rather than FM or abdominal mass accumulation, correlates with large vertebral size and thus potentially also with lower osteoporotic vertebral fracture risk.
Integrated synthesis of nucleotide and nucleosides influenced by amino acids
Authors: Suárez-Marina Irene , Abul-Haija Yousef M. , Turk-MacLeod Rebecca , Gromski Piotr S. , Cooper Geoffrey J. T. , Olivé Andrea Olivé , Colón-Santos Stephanie , Cronin Leroy
Published: March 2019

Research on prebiotic chemistry and the origins of nucleic acids and proteins has traditionally been focussed on only one or the other. However, if nucleotides and amino acids co-existed on the early Earth, their mutual interactions and reactivity should be considered explicitly. Here we set out to investigate nucleotide/nucleoside formation by simple dehydration reactions of constituent building blocks (sugar, phosphate, and nucleobase) in the presence of different amino acids. We demonstrate the simultaneous formation of glycosidic bonds between ribose, purines, and pyrimidines under mild conditions without catalysts or activated reagents, as well as nucleobase exchange, in addition to the simultaneous formation of nucleotide and nucleoside isomers from several nucleobases. Clear differences in the distribution of glycosylation products are observed when glycine is present. This work demonstrates that reaction networks of nucleotides and amino acids should be considered when exploring the emergence of catalytic networks in the context of molecular evolution.
Sorting by interfacial tension (SIFT): label-free selection of live cells based on single-cell metabolism
Authors: Pan Ching W. , Horvath Daniel G. , Braza Samuel , Moore Trevor , Lynch Annabella , Feit Cameron , Abbyad Paul
Published: March 2019

A new label-free and passive microfluidic technique to select cells based on single-cell glycolytic activity. The method has broad applicability and we demonstrate here single-cell droplet encapsulation and selection of live cells.
Polythionine grafted onto magnetic SBA-15 for the removal of cadmium ions from aqueous solutions: isothermal and kinetic studies
Authors: Mehdinia Ali , Mehrabi Hossein , Jabbari Ali
Published: March 2019

Magnetic SBA-15 coated with polythionine was synthesized via the grafting method and used for the adsorption of Cd2+ ions from aqueous solutions.
Preparation of glycoside polymer micelles with antioxidant polyphenolic cores using alkylated poly(arbutin)s
Authors: Seto Ayaka , Kajiwara Rika , Song Jaeeun , Shin Eeseul , Kim Byeong-Su , Kofujita Hisayoshi , Oishi Yoshiyuki , Shibasaki Yuji
Published: March 2019

This paper describes the synthesis of long-chain-alkylated poly(arbutin)s (poly(Arb)-Rx, where R = alkyl-chain length and x = degree of substitution (DS)) and their aqueous micelle formation.
Structural characterization and anti-inflammatory effect in hepatocytes of a galactoglucan fromAntrodia camphoratamycelium
Authors: Tang Huiling , Nie Wenbing , Xiao Jinna , Zha Zhengqi , Chen Qiuli , Yin Hongping
Published: March 2019

A previously undescribed polysaccharide ACP2 was isolated fromAntrodia camphoratamycelium. ACP2 ameliorated hepatocyte inflammation through TLR4 and p38/NF-κB signal pathway.
Thermal conductivity of polyvinylpolymethylsiloxane aerogels with high specific surface area
Authors: Wang Lukai , Feng Junzong , Jiang Yonggang , Li Liangjun , Feng Jian
Published: March 2019

The traditional SiO2 aerogels are difficult to apply in the fields of energy storage and heat insulation due to their poor mechanical properties.
Recent advances of stimuli-responsive systems based on transition metal dichalcogenides for smart cancer therapy
Authors: Zhou Ruxin , Zhu Shuang , Gong Linji , Fu Yanyan , Gu Zhanjun , Zhao Yuliang
Published: March 2019

A comprehensive overview of the development of stimuli-responsive TMDC-based nanoplatforms for “smart” cancer therapy is presented to demonstrate a more intelligent and better controllable therapeutic strategy.
Base-mediated regioselective [3+2] annulation of ketenimines and isocyanides: efficient synthesis of 1,4,5-trisubstituted imidazoles
Authors: Cai Jinxiong , Bai Haijie , Wang Yuan , Xu Xianxiu , Xie Haiming , Liu Jun
Published: March 2019

A novel base-mediated regioselective [3+2] annulation of active methylene isocyanides with ketenimines has been developed.
Attenuation of allergic responses following treatment with resveratrol in anaphylactic models and IgE-mediated mast cells
Authors: Zhang Ya-Fen , Liu Qing-Mei , Gao Yuan-Yuan , Liu Bo , Liu Hong , Cao Min-Jie , Yang Xian-Wen , Liu Guang-Ming
Published: March 2019

Resveratrol isolated from Abies georgei exhibits therapeutic potential for allergic disease induced by food allergens.
Rational design of few-layer MoSe2 confined within ZnSe–C hollow porous spheres for high-performance lithium-ion and sodium-ion batteries
Authors: Zeng Lingxing , Fang Yixing , Xu Lihong , Zheng Cheng , Yang Min-Quan , He Jiafang , Xue Hun , Qian Qingrong , Wei Mingdeng , Chen Qinghua
Published: March 2019

A ZnSe/MoSe2@C composite was fabricated as a high performance anode material for LIBs/SIBs.
Selective growth of monolayer and bilayer graphene patterns by a rapid growth method
Authors: Lakshad Wimalananda Maddumage Don Sandeepa , Kim Jae-Kwan , Lee Ji-Myon
Published: March 2019

Selective surface treatment of a catalytic surface by different plasma treatments to control the number of graphene layers.
Recent advances in micro-supercapacitors
Authors: Zhang Hongxi , Cao Yudong , Chee Mason Oliver Lam , Dong Pei , Ye Mingxin , Shen Jianfeng
Published: March 2019

Micro-supercapacitors (MSCs) possessing the remarkable features of high electrochemical performance and relatively small volume are promising candidates for energy storage in micro-devices.
A pH-induced self-healable shape memory hydrogel with metal-coordination cross-links
Authors: Lu Liuxuan , Tian Tian , Wu Shanshan , Xiang Tao , Zhou Shaobing
Published: March 2019

A 4-armed PEG–DA hydrogel was fabricated, which showed regulated shape memory and self-healing properties at different pH values.
The effect of chain architecture on the phase behavior of A4B4miktoarm block copolymers
Authors: Kim Ki Hyun , Park Jihoon , Choe Youngson , Huh June , Bang Joona
Published: March 2019

Well-defined miktoarm (polystyrene)4-(polylactic acid)4((PS)4-(PLA)4) block copolymers were synthesized and their phase behaviors were compared with linear PS-b-PLA block copolymers, in which the miktoarm architecture enhanced the phase segregation.
Thermoelectric properties of n-type Cu4Sn7S16-based compounds
Authors: Deng Tingting , Wei Tian-Ran , Song Qingfeng , Xu Qing , Ren Dudi , Qiu Pengfei , Shi Xun , Chen Lidong
Published: March 2019

Thermoelectric properties were optimized by Ag-doping in n-type Cu4Sn7S16-based compounds with complex structure, small effective mass and low thermal conductivity.
Grape pomace as a biosorbent for fluoride removal from groundwater
Authors: Zhang Yangzhong , Huang Kai
Published: March 2019

This study presents a new type of biomass material for defluoridation from water; the material was prepared by loading tetravalent zirconium ions onto grape pomace produced from grape juicing and wine factories.
A methanol and protic ionic liquid Ugi multicomponent reaction path to cytotoxic α-phenylacetamido amides
Authors: Al Otaibi Ahmed , Deane Fiona M. , Russell Cecilia C. , Hizartzidis Lacey , McCluskey Siobhann N. , Sakoff Jennette A. , McCluskey Adam
Published: March 2019

The Ugi reaction (aldehyde, amine, isocyanide and an ethanoic acid) in the protic ionic liquids ethylammonium nitrate (EAN) and propylammonium nitrate (PAN) gave excellent yields of α-phenylacetamido amides.
Influence of Cl−ions on anodic polarization behaviour of API X80 steel in high potential/current density conditions in Na2SO4solution
Authors: Qin Runzhi , Du Yanxia , Xu Zhenchang , Lu Minxu
Published: March 2019

X80 steel gets passivated in high potential/current density conditions in Na2SO4solution. Low concentration of Cl−ions weakens the passivation. High concentration of Cl−ions totally prevents the passivation.
A MnO2–[Ru(dpp)3]Cl2 system for colorimetric and fluorimetric dual-readout detection of H2O2
Authors: Zhang Yuan , Hu Kewei , Ling Zhenbao , Di Weihua
Published: March 2019

The MnO2 nanosheets with anchored [Ru(dpp)3]Cl2 were prepared for colorimetric and fluorimetric dual-mode detection of H2O2.
A microwave-activated coal fly ash catalyst for the oxidative elimination of organic pollutants in a Fenton-like process
Authors: Wang Nannan , Xu Han , Li Shuo
Published: March 2019

Raw coal fly ash was activated by microwave irradiation and used as a catalyst for the degradation of organics in a Fenton-like process.
Photocontrolled organic field effect transistors based on the fullerene C60 and spiropyran hybrid molecule
Authors: Tuktarov A. R. , Salikhov R. B. , Khuzin A. A. , Popod'ko N. R. , Safargalin I. N. , Mullagaliev I. N. , Dzhemilev U. M.
Published: March 2019

Photocontrolled organic field-effect transistors (OFETs) containing a hybrid compound of fullerene C60 (n-semiconductor) with spiropyran (electrical conductivity photocontroller) as the active layer were fabricated for the first time.
Magnetically stimulating capillary effect for reversible wet adhesions
Authors: Li Meng , Dai Qingwen , Jiao Qing , Huang Wei , Wang Xiaolei
Published: March 2019

Inspired by the wet adhesion of amphibians, we develop a smart reversible meniscus adhesion system whose capillary effect can be regulated by external magnetic stimuli.
Highly efficient flexible MAPbI3 solar cells with a fullerene derivative-modified SnO2 layer as the electron transport layer
Authors: Zhong Meiyan , Liang Yongqi , Zhang Jianqi , Wei Zhixiang , Li Qi , Xu Dongsheng
Published: March 2019

Specific point was achieved for flexible MAPbI3 solar cells with CPTA modified SnO2 ETL.
A flexible active dual-parameter sensor for sensitive temperature and physiological signal monitoring via integrating thermoelectric and piezoelectric conversion
Authors: Zhu Pengcheng , Wang Yao , Sheng Ming , Wang Yaling , Yu Yuedong , Deng Yuan
Published: March 2019

A flexible active dual-parameter sensor for sensitive temperature and physiological signal monitoring has been developed via integrating thermoelectric and piezoelectric conversion.
Dual-stimulus bilayer hydrogel actuators with rapid, reversible, bidirectional bending behaviors
Authors: He Xiaomin , Sun Yan , Wu Jiahui , Wang Yang , Chen Feng , Fan Ping , Zhong Mingqiang , Xiao Shengwei , Zhang Dong , Yang Jintao , Zheng Jie
Published: March 2019

Bilayer poly(N-isopropylacrylamide)/graphene oxide hydrogels with dual thermo- and near-infrared-responsive properties were prepared by a simple, in situ polymerization centrifugation method.
State‐space analysis based pole‐to‐ground line fault isolation strategy for LCC–HVDC systems
Authors: Dai Zhihui , Liu Ningning , Zhang Cheng , Yan Siqi
Published: March 2019

The common way to isolate the line fault in line‐commutated converter‐based high‐voltage direct current (LCC‐HVDC) transmission grids is regulating the trigger angle of converters on both terminals of the faulted line, which usually depends entirely on the conventional controller and goes with large current peak and lengthy overcurrent duration. In this study, a trigger‐angle setting approach with adaptability is, therefore, proposed to provide a theoretical basis for the generation of fault isolation strategies under different scenarios. First, equivalent circuits of solid pole‐to‐ground line faults at rectifier and inverter terminals are established, and time‐domain expressions of the fault and converter currents are obtained. Secondly, based on the analysis of current characteristics, the non‐linear programming method is utilised to obtain the optimal trigger‐angle sequence after the fault, which can be applied in the following fault isolation. Finally, the proposed approach is verified via power systems computer aided design (PSCAD)/electromagnetic transients including DC (EMTDC) simulation. The results show that it can effectively reduce the current peak and the overcurrent duration of the converter, which is of positive significance for maintaining the power system security and stability.
Single‐switch, integrated DC–DC converter for high‐voltage step‐down applications
Authors: Rodrigues de Oliveira Igor , Silva de Morais Aniel , Tofoli Fernando Lessa
Published: March 2019

An integrated non‐isolated DC–DC converter for applications that demand wide conversion range is proposed in this work. Using a technique known as graft scheme, it is possible to design a single‐switch SEPIC‐buck converter, where both the input current and the current supplied to the output stage composed of the filter capacitor and the load are non‐pulsating when operation occurs in continuous conduction mode (CCM). Therefore, minimised electromagnetic interference (EMI) levels result as a consequence. Besides, the converter requires the use of a single active switch connected to the source reference node, without the need for isolated control circuitry, while it is possible to achieve wider conversion ranges than that provided by the classical buck converter. The qualitative and quantitative analysis of the converter is presented, from which it is possible to design and analyse it. Experimental results are discussed in detail to validate the theoretical considerations.
Comparison of bi‐modal coherent sea clutter simulation techniques
Authors: Rosenberg Luke , Bocquet Stephen
Published: March 2019

Realistic simulation of radar sea‐clutter is extremely important to evaluate radar detection algorithms and to stimulate radar processors during development and testing. Here, the authors compare a number of coherent sea clutter simulation methods designed to model not just the amplitude distribution, but also the time and range varying Doppler spectrum. This is important as the Doppler spectrum plays a key role in determining the statistics that are important for coherent processing. The models studied include the evolving Doppler spectrum model, the spatial and temporal limited clutter model and the compound G2 model which captures many of the features from the other two. To analyse the models, simulated data are generated with parameters estimated from the Ingara medium grazing angle sea clutter data set. Comparison with the original data then allows for a comprehensive study of the strengths and weaknesses of each model over a range of polarisations and swell angles.
LQAC-5: The fifth release of the Large Quasar Astrometric Catalogue
Authors: Souchay J. , Gattano C. , Andrei A. H. , Souami D. , Coelho B. , Barache C. , Taris F. , Secrest N. , Berthereau A.
Published: March 2019

Context. In addition to their great astrophysical interest, quasars represent quasi-ideal reference objects in the celestial sphere with, a priori, a lack of significant proper motion. Since the fourth release of the Large Quasar Astrometric Catalogue (LQAC-4), a large number of quasars have been discovered, in particular those coming from the DR14Q release of the SDSS. With the advent of the Gaia Data Release 2 (DR2), it is now also possible to fold in extremely accurate quasar positions.

Aims. Following the same procedure as in the previous releases of the LQAC, our aim is to compile the large majority of the recorded quasars, with their best estimated coordinates and substantial information about their physical properties such as the redshift, multi-bands apparent, and absolute magnitudes. Emphasis is given to the results of the cross-matches with the Gaia DR2 catalogue, which considerably increases the positional accuracy.

Methods. New quasars from the SDSS DR14Q release were cross-matched with the precedent LQAC-4 compilation with a 1″ search radius, which leads to 149 084 objects not present in the previous LQAC-4 release. Another cross-match was done with the Gaia DR2 catalogue, which enables us to considerably improve the positioning of these objects. For the first time, parallaxes and proper motions from the DR2, when available, are added to our compilation. Furthermore, a cross-identification of the LQAC-5 with the AllWISE survey gives additional mid-infrared information for an important percentage of objects.

Results. Our final catalogue, namely the LQAC-5, contains 592 809 quasars. This represents roughly a 34% increase with respect to the number of objects recorded in the LQAC-4. Among them, 398 697 objects were found in common with the Gaia DR2, within a 1″ search radius. That corresponds to 67.26% of the whole population of the compilation.

Conclusion. The LQAC-5 delivers a nearly complete catalogue of spectroscopically confirmed quasars (including a small proportion of 14 126 compact AGN’s) to the astronomical community, with the aim of giving their best equatorial coordinates with respect to the ICRF2 and with exhaustive additional information. For more than 50% of the sample, these coordinates are extracted from the very recent Gaia DR2.
Three-dimensional model of the Rzeczka object (the Riese Complex, Sowie Range) as an enhancement of the comprehensive geotourism potential of an underground tourist route
Authors: Kądziołka Katarzyna , Kasza Damian , Milczarek Wojciech J.
Published: March 2019

The dynamic development of measurement technology based on the use of laser scanners allows for fast transfer of information, related to terrestrial data, to a virtual environment and enables the creation of three-dimensional models. Because of the growing demand for underground areas inventory, especially historic areas, the creation of 3D numerical models increases in popularity. It allows to increase the geotouristic potential of a particular area and to use solutions in support of the safety of tourists as well as the safety of area itself. The development of the terrestrial laser scanning technique is accompanied simultaneously by the development of means of digital data processing that was obtained in the form of point clouds. Those means use the commercial software as well as software available in the open source system. Both computing environments use algorithms enabling the processing of huge collections of points in automatized mode by using a number of open-access algorithms either freeware or dedicated. The methodology of numerical models development, described in this article, has been presented on the example of underground object “Rzeczka” (“Riese” Complex) located at the Sowie Range (SW Poland).
CFD study on the effects of boundary conditions on air flow through an air-cooled condenser
Authors: Sumara Zdeněk , Šochman Michal
Published: March 2019

This study focuses on the effects of boundary conditions on effectiveness of an air-cooled condenser (ACC). Heat duty of ACC is very often calculated for ideal uniform velocity field which does not correspond to reality. Therefore, this study studies the effect of wind and different landscapes on air flow through ACC. For this study software OpenFOAM was used and the flow was simulated with the use of RANS equations. For verification of numerical setup a model of one ACC cell with dimensions of platform 1.5×1.5 [m] was used. In this experiment static pressures behind fan and air flows through a model of surface of condenser for different rpm of fan were measured. In OpenFOAM software a virtual clone of this experiment was built and different meshes, turbulent models and numerical schemes were tested. After tuning up numerical setup virtual model of real ACC system was built. Influence of wind, landscape and height of ACC on air flow through ACC has been investigated.
Recent advances in characterisation of subsonic axisymmetric nozzles
Authors: Tesař Václav
Published: March 2019

Nozzles are devices generating jets. They are widely used in fluidics and also in active control of flows past bodies. Being practically always a component of larger system, design and optimisation of the system needs characterisation of nozzle properties by an invariant quantity. Perhaps surprisingly, no suitable invariant has been so far introduced. This article surveys approaches to characterisation quantities and presents several examples of their typical use in systems such as parallel operation of two nozzles, matching a nozzle to its fluid supply source, apparent resistance increase in flows with pulsation, and the secondary invariants of a family of quasi-similar nozzles.
Flow Structure behind a Wing at High Reynolds Numbers
Authors: Uruba Václav , Pátek Zdeněk , Procházka Pavel , Skála Vladislav , Zacho David , Kulhánek Robert
Published: March 2019

The stereo PIV measurement were performed behind a wing in the plane perpendicular to the flow to study the vortical structures oriented in the streamwise direction, which take place both in suction and pressure sides of the wing. The Reynolds numbers during the experiments in the 3 m wind tunnel range from 0.5 million up to 1.5 million.
Radioisotope measurement of selected parameters of liquid-gas flow using single detector system
Authors: Zych Marcin , Hanus Robert , Jaszczur Marek , Mosorov Volodymyr , Świsulski Dariusz
Published: March 2019

To determine the parameters of two-phase flows using radioisotopes, usually two detectors are used. Knowing the distance between them, the velocity of the dispersed phase is calculated based on time delay estimation. Such a measurement system requires the use of two gamma-ray sealed sources. But in some situations it is also possible to determine velocity of dispersed phase using only one scintillation probe and one gamma-ray source. However, this requires proper signal analysis and prior calibration. This may also cause larger measurement errors. On the other hand, it allows measurements in hard to reach areas where there is often no place for the second detector. Additionally, by performing a previous calibration, it is possible to determine the void fraction or concentration of the selected phase. In this work an autocorrelation function was used to analyze the signal from the scintillation detector, which allowed for the determination of air velocities in slug and plug flows with an accuracy of 8.5%. Based on the analysis of the same signal, a void fraction with error of 15% was determined.
Mandibular exostosis following an epithelial–conjunctival graft: a case report
Authors: Sturque Julie , Castain Claire , Fricain Jean-Christophe
Published: March 2019

Observation: A 68-year-old patient presented to us because of the gradual onset of symptoms associated with a mass located on an epithelial–mucosal graft performed approximately 20 years ago. A provisional diagnosis of exostosis was made and the mass was excised under local anesthesia. Comments: Exostosis is defined as a localized benign bone proliferation constituting a sessile nodular bony outgrowth with either a broad base or a peduncle attaching to the parent bone. Some cases of exostosis secondary to the realization of gingival grafts have been reported in the literature. Thus, exostosis should be considered as an unpredictable side effect of this surgical procedure.
Arabic translation and validation of three knee scores, Lysholm Knee Score (LKS), Oxford Knee Score (OKS), and International Knee Documentation Committee Subjective Knee Form (IKDC)
Authors: Ahmed Khamis Mohamed , Said Hatem G. , Ramadan Eslam Karam Allah , Abd El-Radi Mohamed , El-Assal Maher A.
Published: March 2019

Aim of the work: Translation and validation of three commonly used knee scores to Arabic language: the Lysholm Knee Score (LKS), the Oxford Knee Score (OKS), and IKDC Subjective Knee Form.

Methods: Our work focused on translation and validation of the LKS, OKS and IKDC. Construct validity was assessed by comparing the LKS, OKS, and IKDC Subjective Knee Form and previous Arabic translated version of Knee injury and Osteoarthritis Outcome Score (KOOS). Test−retest reliability, internal consistency, and construct validity were assessed, using Intraclass Correlation Coefficient (ICC), Cronbach's alpha, and Pearson correlation coefficient (r).

Results: Reliability was excellent for the Arabic IKDC subjective form (0.95), while the Arabic LKS and the Arabic OKS were good: 0.8 and 0.85, respectively. The Cronbach's ά was excellent for the Arabic LKS and Arabic OKS: 0.9 and 0.90, respectively, while the Arabic IKDC subjective form was good (0.89). Construct validity was high for the Arabic LKS and the Arabic OKS: 0.7 and 0.913, respectively, while the Arabic IKDC was moderate (0.4) in cases of ACL and meniscus injuries and mild (0.18) in cases of osteoarthritis.

Conclusion: Arabic LKS and Arabic OKS were reliable and valid scores for patients complaining of ligamentous injuries, meniscus injuries, and osteoarthritis to be used for Arabic-speaking people, while the Arabic IKDC had excellent reliability and mild validity in cases of osteoarthritis and moderate validity in cases of ACL and meniscus injuries.
Wie laut ist das denn?!
Authors: Fritzsche Christian , Heinicke Tobias , Siegel Daniel
Published: March 2019

Telefonläuten, Klimaanlagen, das Schließen von Türen – all das verursacht Lärm.
Auf Intensivstationen kommen dann noch die Geräuschpegel und Alarme der diversen
Überwachungsgeräte hinzu, und auch das Personal und die Patienten selbst
verursachen Lärm. Wird er zu groß, hat er nicht nur negative Auswirkungen auf
den Genesungsprozess der Patienten. Auch das Pflegepersonal leidet. Lärm
beeinträchtigt nicht nur ihre Konzentration und Aufmerksamkeit, sondern kann
auch ihre Gesundheit dauerhaft schädigen.
Alles gleichzeitig und trotzdem gut? (Teil
1)
Authors: Zoller Richard , Lange Kathrin , Nowak Miriam , Lauer Wolfgang
Published: March 2019

Der Arbeitsbereich von Intensivpflegenden beinhaltet neben der professionellen
Pflege der Patienten auch den zuverlässigen Umgang mit Technik- und
Medizinprodukten aller Art. Die anfallenden Aufgaben sind dabei meist wenig
planbar, schneller Aufgabenwechsel und das gleichzeitige Erledigen verschiedener
Tätigkeiten sind charakteristisch für das Tätigkeitsfeld. Welche Auswirkungen
aber hat dieses Multitasking auf die Sicherheit im Umgang mit
Medizinprodukten?
Kopfschmerzen – Update 2018
Authors: Diener Hans-Christoph , Gaul Charly , Holle-Lee Dagny , Jürgens Tim P. , Kraya Torsten , Kurth Tobias , Nägel Steffen , Neeb Lars , Straube Andreas
Published: March 2019

Die Kopfschmerzforschung macht Fortschritte. Dies zeigt sich an der großen Zahl
von Publikationen zur Epidemiologie, Pathophysiologie, Akuttherapie und
Prophylaxe von Kopfschmerzen. Die vorliegende Übersicht referiert die
wichtigsten Studien zu Kopfschmerzen aus dem Zeitraum 2017 bis Juni 2018. Die
Auswahl der referierten Studien ist subjektiv und erfolgte nach der Einschätzung
der Autoren.
Vinylation of Carbonyl Oxygen in 4-Hydroxycoumarin: Synthesis of Heteroarylated Vinyl Ethers
Authors: Chatterjee Rana , Santra Sougata , Zyryanov Grigory , Majee Adinath
Published: March 2019

The unique nucleophilic character of the carbonyl oxygen of 4-hydroxy coumarin has been observed by the BF3·OEt2 catalyzed reaction of 4-hydroxycoumarin and alkynes. The reactions of 4-hydroxycoumarin and substituted 4-hydroxycoumarin with various terminal alkynes have been studied. In case of internal alkyne (prop-1-yn-1-ylbenzene), the reaction with 4-hydroxycoumarin led to the corresponding product with an E/Z ratio of 3:1. This protocol is operationally very simple and has much potential for the synthesis of heteroarylated vinyl ethers from basic chemicals.
Free Flap Reconstruction of the Maxilla
Authors: Vincent Aurora , Burkes Jason , Williams Fayette , Ducic Yadranko
Published: March 2019

Tumors of the maxilla and midface are some of the most difficult to manage, not only in terms of treatment but also in terms of achieving acceptable orofacial reconstruction. Today, free flaps dominate the reconstructive field. Many patients can achieve successful reconstruction after free flap transfer with a return of intelligible speech, a regular diet, and acceptable cosmesis. Herein, the authors review free flap reconstruction of the maxilla, with a focus on the classifications of defects, when obturators are appropriate, types and sources of free flaps, and complications for which to beware.