Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry
Authors: Hudak Mark L. , Flannery Dustin D. , Barnette Kimberly , Getzlaff Trace , Gautam Shiva , Dhudasia Miren B. , Mukhopadhyay Sagori , Pfeifer Madeline R. , Ellington Sascha R. , Galang Romeo R. , Snead Margaret C. , Woodworth Kate R. , Zapata Lauren B. , Puopolo Karen M. ,   THE AMERICAN ACADEMY OF PEDIATRICS NPC-19 REGISTRY INVESTIGATORS, Hall Richard Whit , Janssen Dalton , Gomez Enrique , McNew Hailey , Steen Christal , Cole Evguenia , Graff Brenda , Rao Suma , Kathiravan Suganya , Wade Christina , Mikhael Michel , Vargas-Shiraishi Ofelia , Rosales Juliann , Lai Pui Y. , Patel Rupal , Le Loc , Jones Sophia , Bahramianfard Gazelle , Bennett Stacie , Kuzniewicz Michael , Fischer Allen , Walsh Eileen , Zhu Suyi , Acuna Brigid , Easterlin Molly , Biniwale Manoj , Barton Lorayne , Biniwale Manoj , Ramanathan Rangasamy , Maggiotto Liesbeth , Patel Devang , Shum Fred , Batistelli Lisa , Sun Wang-Dar , Rodriguez Hellen , Schnaar Kenna , Moyer Laurel , Lazar Sarah , Bui Jordan , Crabtree Melanie , Jegatheesan Priya , Huang Angela , Devarajan Kamakshi , Colorado Valerie , Mancao Edna , Kar Renuka , Ransil Maria , Morton Cynthia , Sheng Lavonne , Zeilinger Terry , Uy Cherry , Aron-Johnson Pam , Fernandez Ericka , Lazar Sarah , Bui Jordan , Crabtree Melanie , Fossi Sabrina , D’Harlingue Arthur , Hagen Patricia , Pena Rachel , Feinberg Michelle , Celvenger Laura , Allen Kelly , Wymore Erica , Wheeler Colleen , Allen Kelly , Houin Sadie , Jones Erin , Allen Kelly , Pantoja Alfonso , Alonzo Corrie , Wildenstein Allie , Allen Kelly , Wright Clyde , Scott Jessica , Pugh Mary , Townsend Sue , Beard Lauren , Barrett Wendy , Zenge Jeanne , Hannan Kathleen , Golioto Annmarie , Cyr Nancy , Motta Sandra , Mangs Jessie , Sheehan Juliann , O’Callahan Cliff , Pittari Laura , Buck Catherine , Henry Christine , Zamary Taryn , Soghier Lamia , Perazzo Sofia , Israel Smith , Sherwood Ashley , Guillen Ursula , Mackley Amy , Liu William , Duara Shahnaz , Aguilar Ana Cecilia , Van Buskirk Silvia , Mitchell Jan , Ferry Jenelle , Eldridge Whitney , Randis Tara M. , Kneusel Marcia , Cortez Josef , Maddox Ashley , Burchfield David , Sura Livia , Prete Rachel , Tinder Cindy , Day-Richardson Colby , Maddox Ashley , Pratt Michelle , Loggins Yvonne , Martin Lisa , Loggins Yvonne , Patel Ravi , Ranganathan Deepa , Loggins Yvonne , Mackie Colleen , Schulman Bridgette , Williams Aubrey , Hinkes Mike , Grier Katrina , Benston Janna , McLean Joseph , Scaccia Meredith , Daigle Jessica , Kuo Sheree , Tong Micah , Prescott Alicia , Staiger Lauren , Sherman William , Elgin Timothy , Johnson Karen , Merchant Jennifer , Parks Nichele , Machut Kerri , Mithal Leena , Schau Molly , MacKendrick William , Wolf Sue , Brennan Rita , Kopec Gretchen , Astle Michele , Knapik Melissa , Berenz Andrew , Gross Megan , Malloy Colleen , Paolella Marilyn , Carlos Christine , Yzchaki Elena , Pillers De-Ann , Kadhem Zaynab , Cooper Sara , Romano-Keeler Joann , Batton Beau , Spenner Allison , Bauer Erin , Tauscher Markus , Tauscher Zenaida , Sokol Gregory , Engelstad Leah , Rakow Hannah , Weatherstone Kathleen , Howlett Jessica , Singh Tamina , Houston Stephanie , Chumbley JenniferNason Brittany , Bauer John , McKinney-Whitlock Beth , DeGraff Susan , Patrick-Esteve Jessica , Joslyn Peter , Mumphrey Christy , Lindsay Elizabeth , Steinhardt Michelle , Smitley Leslie , Diles Monique , Spedale Steven B. , Vaidya Ruben , Singh Rachana , Wagner Katie , Zupancic John , Chaudhary Neha , Culic Ivana , O’Connell Amy , Parker Margaret , Sabharwal Vishakha , Tucker Lisa , Bartolome Ruby , Houston Stephanie , Brownrigg Maggie , Belfort Mandy , Drouin Kaitlin , Steele Tina , Chaudhary Neha , Shui Jessica , Patrizi Silvia , Maron Jill L. , Mahmoud Taysir , Sullivan Katherine , White Heather , Kalyanasundaram Archana , Vasquez Crystal , Yanni Diana , Angelidou Asimenia , Kohorn IsabelleVon , Rondon Karla , Donohue Pamela , Shepard Jennifer , Subramanian Siva , Spriggs Tiffany , Smith Kristen , Picarillo Alan , Colombo David , Beltz Emily , Nystrom Kathy , Ezhuthachan Sudhakar , Abraam Heather , Jani Sanket , Bajaj Monica , Lua Jorge , Binyard Shanita , Omar Said , Abernathy Cheryl , Hackett Sara , Gelfand Steven , Smith Stacy , Vartanian Rebecca , White Diane , Pace Rachael , Gale Cheryl , Hanson Amy , Demeules Martha , Plautz Emiliee , Wassenaar Jenna , Bendel-Stenzel Ellen , Haines Kelly , Julian Samuel , Linneman Laura , Josephsen Justin , Hawkins Melissa , Desai Jagdish , Williams Heather , Diaz Aurora , Dankhara Nilesh , Rentz Alison , Saxonhouse Matthew , Harris Gail , Shenberger Jeffrey S , Ingram Cobi , Weimer Kristin , Babilonia-Rosa Melissa , Marion Mandy , Bear Kelly , Moseley Sherri , Miller Ansley , Cascio Mary , Taylor Genevieve , Talbert Jennifer , Clark Cynthia , Kicklighter Stephen , White Donna , Sweeney Alison , Samaras Athena , Anderson-Berry Ann , Oberle Betty , Petersen Kerry , Spillane Nicole , Toczylowski Krsytyna , Mintzer Jonathan , Lespinasse Antoine Alexandra , Peters Caryn , Chan Kwanchai , Cialfi DeborahAnn , Skroce Linda , Kaur Harpreet , Thomas Rani , Ghavam Sarvam , Catts Christine , Snyder Jonathan , Fuller Janelle , Beauman Sandra , Lacy Conra Backstrom , Tristram Debra , Cook Philip , Celetano Donna , Rooney Carol , Garey Donna , Leone Tina , Ehret Caitlin , Havranaek Thomas , El-Hennawy Magdy , Chandrasekharan Praveen , Li Emily , Donato Jennifer , La γ Edmund , Shah Shetal , Giblin Clare , Vaz Michelle , Verma Sourabh , Auyeung N. S. Freda , Farrell Paula , Culp Marybeth , Peters Terri , Scheible Kristin , Prideaux Mallory , Jones Rachel , Scalise Tanya , Tiozzo Caterina , Stein Howard , Shoemaker Jessica , Brar Gagandeep , Parker Kelly , Calcamuggio Christine , Walsh Michele C. , Hibbs Anna Maria , Newman Nancy , Desai Riddhi , DeFranco Emily , Bach Lynea , Gurney-McMaster Allison , Williams Patricia , McCoy Mike , Wilson Shannon , Ivanov Vadim , McCoy Mike , Redden Hilary , Dukhovny Dmitry , Rincon Monica , Ivanovic Milica , Kaempf Joe , Chen Chiayi , Tipping Nicole , Cohen Howard , Hickey Kristin , Keeth Lori , Traudt Christopher , Kauffman Kathryn , Salvador Agnes , Cameron Gail , Sadashiv Sandeep , Cook James A. , Moran Karena , Taylor Heidi , Polavarapu Sruthi , Yanowitz Toby , D’Orto Victoria , Farkouh-Karoleski Christiana , Bischoff Peggy , Abebe Elias , Goodstein Michael , Eppinger Michelle , Foglia Elizabeth , Munson David , Pfeifer Madeline , Ross Julie , Mikell Ebony Dawkins , Uy Imelda , Talavera-Barber Maria , Friedrich Christa , Sundleaf Jessica , Balay Kim , Fitzgerald Nan , O’Leary Tara , Baack Michelle , Henning Megan , Muyden Sarah Van , Gilliam Heather , Go Josefina , Richards Laura , Lamba Vineet , Camp Gail , Gutman Courtney , Gipson Kristen , Weitkamp Joern-Hendrik , Rogers Theresa , Ahmad Kaashif , Drummond Melanie , Kohlleppel Katy , Vereen Rasheda , Drumm Caitlin , Brion Luc , Caraig Maria , Vanguyen Emilie , Chang Michael , Bianco Gabriela Del , Brion Luc , Caraig Maria , Trout Erin , Frias-Esparza Karina , Payton Brooke , Sisman Julide , Cantey Joseph B. , Guerra Diana , Baserga Mariana , Loertscher Manndi , Lund Kelli , Hendricks-Munoz Karen , Russell Moores , Astoria Mark , Fabian Karen , Swanson Jonathan R. , Thielen Monika , Lee Edward I. , Long Christina , Cohen Toby , Goetz Elizabeth , Limjoco Jamie , Menda Nina , Govindaswami Balaji , Haas Jessica 
Published: January 2023

OBJECTIVES

The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

METHODS

National Registry for the Surveillance and Epidemiology of Perinatal COVID-19 participating centers entered maternal and newborn data for pregnant persons who tested positive for SARS-CoV-2 infection between 14 days before and 10 days after delivery. Incidence of and morbidities associated with maternal and newborn SARS-CoV-2 infection were assessed.

RESULTS

From April 6, 2020 to March 19, 2021, 242 centers in the United States centers reported data for 7524 pregnant persons; at the time of delivery, 78.1% of these persons were asymptomatic, 18.2% were symptomatic but not hospitalized specifically for COVID-19, 3.4% were hospitalized for COVID-19 treatment, and 18 (0.2%) died in the hospital of COVID-related complications. Among 7648 newborns, 6486 (84.8%) were tested for SARS-CoV-2, and 144 (2.2%) were positive; the highest rate of newborn infection was observed when mothers first tested positive in the immediate postpartum period (17 of 125, 13.6%). No newborn deaths were attributable to SARS-CoV-2 infection. Overall, 15.6% of newborns were preterm: among tested newborns, 30.1% of polymerase chain reaction-positive and 16.2% of polymerase chain reaction-negative were born preterm (P &lt; .001). Need for mechanical ventilation did not differ by newborn SARS-CoV-2 test result, but those with positive tests were more likely to be admitted to a NICU.

CONCLUSIONS

Early in the pandemic, SARS-CoV-2 infection was acquired by newborns at variable rates and without apparent short-term effects. During a period that preceded widespread availability of vaccines, we observed higher than expected numbers of preterm births and maternal in-hospital deaths.