bluuebunny/crossref_metadata_2025 huggingface dataset:
Формування додаткових структурних модулів медично-реабілітаційних центрів політравми у воєнний час
Authors: Красножон Тетяна Юріївна
Published: August 2022

У даній статті розглянуто формування додаткових структурних модулів медично-реабілітаційних центрів політравми у воєнний час на базі наявних установ даного типу, на об’ємно-просторове вирішення котрих безпосередньо впливають обрані архітектурно-конструктивні системи.Архітектура медично-реабілітаційних центрів політравми у воєнний час вимагає організації додаткових структурних модулів на основі введення нових будівельних об’ємів на територію закладу та адаптацію існуючих функціональних блоків установи до нових вимог медико-технологічного процесу виходячи зі змін у переважаючих типах ушкоджень, що характеризуються множинними, поєднаними та комбінованими ураженнями із вираженим проявом синдрому взаємного погіршення.У ході дослідження було встановлено, що структура бойової хірургічної та терапевтичної травм має тенденцію до зміни з часом, що обумовлено розвитком озброєння та особливостями характеру ведення бойових дій, тому архітектура додаткових структурних модулів медично-реабілітаційних центрів політравми вимагає попередньої гнучкості в архітектурно-просторовому плануванні лікувально-реабілітаційного середовища, що здатне швидко адаптуватися до нових вимог медицини воєнного часу. Розглянуто основні етапи еволюції формування медично-реабілітаційних установ для учасників бойових дій.Під час аналізу архітектурно-конструктивних систем закладів охорони здоров’я, зокрема медично-реабілітаційних центрів, були виявлені основні конструктивні вимоги до формування нових будівельних об’ємів додаткових структурних модулів, а також встановлені основні фактори, що впливають на трансформативно-адаптаційне перетворення наявного простору функціональних блоків установи.На основі проведеного аналізу архітектурно-конструктивних систем установ даного типу були надані рекомендації щодо формування додаткових структурних модулів медично-реабілітаційних центрів політравми у воєнний час на базі існуючих установ за двома напрямами: організація окремих будівельних об’ємів та адаптація існуючих функціональних блоківОтже, згідно до поставленої мети дослідження, що полягає у визначенні особливостей архітектурно-просторової організації додаткових структурних модулів медично-реабілітаційних центрів політравми у воєнний час на основі архітектурно-конструктивних рішень, автором було проаналізовано теоретичне підґрунтя дослідження, охарактеризовано специфіку бойової хірургічної та терапевтичної травми, що є безпосередньо превалюючим типом уражень під час бойових дій, виявлено основні конструктивні вимоги та встановлено основні фактори впливу на архітектурно-просторову організацію додаткових структурних модулів медично-реабілітаційних центрів політравми
Особливості використання методів моделювання транспортних потоків на вулично-дорожній мережі міста
Authors: Степанчук Олександр Васильович , Лапенко Олександр Іванович , Чернишова Оксана Сергіївна
Published: August 2022

Мета дослідження полягає в проведенні аналізу методів моделювання транспортних потоків на вулично-дорожній мережі міст, виявленні проблем щодо їхнього використання та впровадження в сучасних умовах розвитку й функціонування міст та життєдіяльності населення; узагальненні результатів підходів щодо існуючих моделей руху транспортних потоків по вулично-дорожній мережі міст. У дослідженні виконано опис та аналіз задач, що вирішуються за допомогою використання методології теорії транспортних потоків та дозволяють покращити умови руху транспортних засобів по магістральних вулицях міста. Здійснено обґрунтування функціональної класифікації математичних моделей транспортних потоків, де були розглянуті моделі прогнозу завантаження транспортної мережі, моделі динаміки транспортного потоку, моделі оптимізації функціонування транспортної мережі. У статті подано та розглянуто напрямки вдосконалення системи управління транспортними потоками в цілому по вуличній мережі всього міста, а також розглянуто наукові концепції та теоретичні положення з розподілення транспортних засобів по вулично-дорожній мережі, які дозволять в режимі реального часу вирішувати задачі оптимального управління транспортними потоками.Проведене дослідження дозволило виконати аналіз існуючих методів моделювання транспортних потоків на вулично-дорожній мережі міст і розробити загальну концепцію їхнього впровадження в систему управління міським вуличним рухом. Отриманий науковий результат є підґрунтям для подальших теоретичних і прикладних досліджень, які направлені на розробку інтелектуальної системи управління вуличним рухом.
Permanência escolar na EJA: narrativas de estudantes do ensino fundamental no Sertão Alagoano
Authors: Freitas Marinaide , Reis Rosemeire , Torres Andresso
Published: August 2022

Este artigo tem como objetivo analisar as narrativas dos/as jovens estudantes da Educação de Jovens e Adultos, de uma escola pública noturna do sertão alagoano, considerando como são construídos os percursos de permanência escolar. É parte de uma pesquisa que teve como coleta de dados a entrevista semiestruturada, tendo como abordagem metodológica a pesquisa qualitativa, assente nos estudos das juventudes e da permanência escolar, entrelaçadas no campo da EJA. Evidenciou o sonho como fator mais preponderante, sendo perseguido por um esforço individual, e paralelo a discursos que intentam conformar os sujeitos a determinados lugares, que, por sua vez, são recusados, ganhando cada vez mais a persistência na busca por um futuro diferente do presente vivido.
Até quando as máscaras brancas? Educação e racismo em Moçambique
Authors: Humbane Eduardo Moises Jamisse , Chemane Orlando Daniel
Published: August 2022

Moçambique é uma ex-colónia portuguesa. A colonização portuguesa ficou tristemente célebre pelo seu caracter assimilacionista, quer dizer, procurou converter os moçambicanos em pretensos cidadãos portugueses, sendo que a escola formal jogou um papel central neste desiderato. Portanto, foi uma escola profundamente permeada pelo racismo e as consequências sociais na quebra de autoestima dos moçambicanos foi significativa. Actualmente Moçambique é um país independente. Os nacionalistas moçambicanos que levaram a cabo a luta anticolonial fizeram do combate ao racismo uma das suas principais bandeiras. O interesse deste artigo é argumentar em torno da ideia de que com a Independência, a escola moçambicana não foi transformada na sua ideologia racista nomeadamente da inferioridade do negro, sem cultura e sem história. Mais concretamente, se procurará compreender, com recurso a contribuição teórica de Fanoz, Freire e pensadores libertários africanos Biko (1990), Mondlane (1995) o processo de transformação da escola branca europeia para uma escola indígena africana tomando a categoria de raça como uma criação histórica e não propriamente uma essência biológica. Será examinada a Lei 4/83 que foi a lei que criou o primeiro sistema nacional de educação de Moçambique. Merecerão revisão bibliográfica autores moçambicanos que, de certo modo preocuparam-se com o tema a partir de outros conceitos (CASTIANO; NGOENHA; BERTHOUD, 2005; MAZULA, 1995), enquanto nós nos perguntaremos, a partir da perspectiva de raça, se a escola moçambicana é multicultural, um lugar de desconstrução da ideologia racista e, dessa forma, de produção de um cidadão orgulhoso da sua identidade negra.
A gestão democrática e suas novas feições no transcurso histórico brasileiro
Authors: Aguiar Viviane Barbosa Perez , Ruiz Maria José Ferreira , Marinheiro Edwylson de Lima
Published: August 2022

Este artigo versa sobre as mudanças provocadas pelos ordenamentos legais, no que tange ao princípio da gestão democrática, ao longo do processo histórico brasileiro. Discute como a legislação educacional, neste país, acomodou novos ideais, influenciada pelas políticas neoliberais de internacionalização do capital. O texto apresenta uma análise de como os dispositivos legais da educação se adequaram à conjuntura política e social, demonstrando-se vulneráveis aos interesses de grupos econômicos. O objetivo geral é apresentar os retrocessos da gestão democrática ao associar-se aos fundamentos neoliberais, desconstruindo o sentido atribuído ao princípio constitucional. Pretende, especificamente, (i) demonstrar como a legislação educacional brasileira incorporou elementos neoliberais, e (ii) analisar a orientação política que direcionou as novas inserções na lei. O estudo pautou-se no desenvolvimento de pesquisa bibliográfica e análise documental. Conclui que os municípios, estados e o Distrito Federal como unidades autônomas da federação (ainda que necessitem de articulação para a efetivação do sistema nacional de educação) reproduzem os ideais neoliberais aparentes no modelo de gestão gerencial da escola, obscurecendo as práticas participativas e de controle social como expressão da gestão democrática, enquanto princípio constitucional.
Covid-19 e educação básica: reflexões sobre riscos e controle espacial no retorno às aulas presenciais
Authors: Darsie Camilo , Furtado Roberval Angelo
Published: August 2022

A pandemia de Covid-19 impactou a área educacional causando a suspensão das aulas presenciais como forma de evitar a propagação da doença no Brasil. Na Educação Básica, ocasionou dificuldades que, no início da crise, estiveram relacionadas, principalmente, às práticas remotas. Porém, com a chegada do segundo semestre de 2020, iniciaram-se os movimentos de retorno às aulas presenciais, fazendo com que os riscos e as estratégias de controle espacial de retomada das atividades escolares tenham se tornado centrais. O texto apresenta uma reflexão qualitativa acerca dos riscos relacionados ao retorno às aulas e aos modos de contorná-los que são propostos em documentos elaborados pela União Nacional dos Dirigentes Municipais de Educação (UNDIME), pelo Conselho Nacional dos Secretários de Educação (CONSED) e pela Confederação Nacional dos Trabalhadores em Educação (CNTE). As reflexões são baseadas em questões relativas ao conceito de risco e à prática de controle espacial, abordadas por teóricos que circulam tanto na área da Educação quanto em outras áreas do conhecimento. Entende-se que os documentos operam com a mensuração de riscos diversos e elegem os que envolvem a Covid 19 contornáveis quando comparados a outros problemas sociais brasileiros. O distanciamento social emerge como possível solução, mas deve ser entendido como uma prática coletiva que depende de todos para o seu sucesso.
Zasada ochrony uzasadnionych oczekiwań. Refleksje na gruncie prawa podatkowego
Authors: Ćwik-Bury Agata
Published: August 2022

Artykuł podejmuje problematykę ochrony prawnej podatnika, opartej na zasadzie uzasadnionych oczekiwań, odkodowanej w orzecznictwie Trybunału Sprawiedliwości Unii Europejskiej. Autorka podkreśla, że z utrwalonego orzecznictwa wynika, iż prawo do ochrony prawnej opartej na zasadzie ochrony uzasadnionych oczekiwań odnosi się do każdego podatnika w sytuacji, w której organ administracji wzbudził u tej osoby, wskutek udzielonych jej precyzyjnych zapewnień, pewne prawnie chronione oczekiwanie.
Physico-chemical profile of historical Ramala Water Reservoir of Chandrapur Maharashtra
Authors: Chilke Arun , Khinchi Pruthviraj
Published: August 2022

Ramala water reservoir is located in the heart of Chandrapur city constructed by Gond king around 600 years back with the purpose to provide water to the citizens for various uses.  However, at present, the condition of this reservoir is much pathetic which leads not only to the death of the fishes but the posing threat to the citizens' health. Therefore, the present work was carried out to find out the physico-chemical perspective of this lake.  This study is experimental in nature. The Ramala water reservoir was the subject of study. The water samples were collected once in the middle of the month from November 2020 to March 2021. Almost all parameters except phosphate and nitrate were shown to contain under the permissible limit and indicate water may be consumed.  The boom in aquatic vegetation is observed due to a high degree of eutrophication. It has been concluded through the study that the water under study is useful for human consumption and also for fisheries.
 
Keywords: Eutrophication; physico-chemical; pollution; water; WQI.
GENDER AND AGE CHARACTERISTICS OF HOSPITALIZED MORBIDITY DUE TO ACUTE POISONING WITH SYNTHETIC NARCOTIC DRUGS IN THE CITY OF OMSK
Authors:   Omsk State Medical University of the Ministry of Health of the Russian Federation, Omsk, Russia, Sabaev A.V. , Pasechnik O.A. ,   Omsk State Medical University of the Ministry of Health of the Russian Federation, Omsk, Russia, Kanarskaya S.V. ,   Omsk State Medical University of the Ministry of Health of the Russian Federation, Omsk, Russia
Published: August 2022

Significance. Studying levels and dynamics in morbidity due to acute poisoning with synthetic drugs makes it possible to assess the state of the toxicological situation at the regional level and formulate directions of preventive work in the context of chemical safety of the territory. The purpose of the study. To analyze gender and age characteristics of hospitalized morbidity in the city of Omsk due to acute poisoning with synthetic drugs (psychodisleptics and hallucinogens) from 2012 to 2020 with a breakdown on gender and age. Material and methods. In the statistical processing of the research materials, methods of alternative (intensive indicators) and graphical analysis were used, indicators of dynamic series were calculated. Results. During the period from 2012 to 2020 in the city of Omsk, the frequency of cases of hospitalization due to acute poisoning with synthetic drugs (psychodisleptics and hallucinogens) increased 2.7 times. The level of hospitalization due to poisoning with synthetic drugs (psychodisleptics and hallucinogens) among men during the entire period under study significantly exceeds the similar indicators among women - 10-fold, on average. The highest rates of hospitalized morbidity among men were registered from 2012 to 2015 among people aged 15-19, and from 2016 to 2020 among men aged 20-29. A statistically significant increase in the level of hospitalized morbidity due to poisoning with synthetic drugs (psychodisleptics and hallucinogens) is registered among men aged 15-19, 20-29, 30-39 and 40-49. In females, the highest rates of hospitalized morbidity due to poisoning with synthetic drugs (psychodisleptics and hallucinogens) during the entire period under study are registered among women aged 15-19. A statistically significant increase in hospitalized morbidity due to poisoning with synthetic drugs (psychodisleptics and hallucinogens) is registered among women aged 15-19, 20-29, and 30-39. Conclusion. Acute poisoning with synthetic drugs (psychodisleptics and hallucinogens) is common in the adolescent and youth communities mainly among the male population, making it possible to state with a high degree of probability the presence of gender and age determinants of the medical and social component of health among population of the city of Omsk.
ISSUES OF MEDICAL CARE ORGANIZATION IN THE LIGHT OF THE CURRENT MODELS OF HEALTH CARE SYSTEMS IN THE WORLD. ANALYTICAL REVIEW
Authors:   Maryam Private Hospital, Kabul, Afghanistan, Khurami Mir Oko ,   Tajik Scientific Research Institute of Preventive Medicine, Dushanbe, Tajikistan, Akhmedov A. ,   Medical and Social Institute of Tajikistan, Dushanbe, Tajikistan, Tursunov R.A. ,   Tajik Scientific Research Institute of Preventive Medicine, Dushanbe, Tajikistan,   Tajik National University, Faculty of Medicine, Dushanbe, Tajikistan, Olimov D.A. ,   Tajik Scientific Research Institute of Preventive Medicine, Dushanbe, Tajikistan
Published: August 2022

Significance. Changes in the social and economic development of any society pose fundamentally new challenges for the medical industry aimed at creating an accessible and effective health care system. Currently, the whole world is looking for ways to reasonably regulate the health сare system in a market economy. The purpose of the study is to conduct a chronological description of the main models of health care systems in the world and an assessment of modern trends in medical care provision to the population Material and methods. To analyze scientific literature, results of modern research on implementing various models in health care systems of the highly developed countries were used. Results. The main characteristics of the models of health care systems in the world, which are fundamentally different from each other, have been outlined: the state-funded (budgetary, public system), which is most comprehensively and conspicuously realized in the UK; predominantly the insurance system (most fully and clearly implemented in Germany and Israel) and the private (paid) system (most typical of the U.S. healthcare). Conclusion. Analysis of the global trends in health care development shows that there is no ideal model of the health care system in the world. Therefore, in order to organize an effective system of public health, it is necessary to adopt the experience of the developed countries on the basis of the state regulation of the health care system, taking into account various trends in the market economy.
Prediction of outcomes for symptomatic spinal cavernous malformation surgery: a multicenter prospective clinical study
Authors: Huang Qiang , Liu Tong , Wang Lichao , Zhang Shizhong , Han Hao , Du Kangjie , Chen Xin , Zhao Zilong , Zhao Liwen , Xie Jiapeng , Zhao Lu , Peng Zhijun , Zhu Tao
Published: August 2022

Objective: Clinical outcome of spinal cavernous malformation (SCM) varies because of its unclear natural history and reliable prognostic prediction model for SCM patients is limited. The aim of the present study was to investigate potential factors that predict one year neurological status in postoperative patients with SCM.Methods: This was a multicenter prospective observational study in consecutive patients with SCMs. SCMs treated microsurgically between January 2015 and January 2021 were included. Outcome was defined as Frankel Scale (ranging from A to E) at one year after operation. Multivariable analyses were used to construct the best predictive model for patient outcomes.Results: We identified 268 eligible SCM patients. Neurological outcome had worsened from preoperative baseline in 51 patients (19.0%) at one year. In the multivariable logistic regression, the best predictive model for unfavorable outcome included symptom duration ≥ 26 moths (95% CI: 2.80-16.96, P < 0.001), size ≤5 mm (95% CI: 1.43-13.50, P = 0.010), complete intramedullary (95% CI: 1.69-8.14, P = 0.001), subarachnoid hemorrhage (95% CI: 2.92-12.57, P < 0.001), Frankel Grade B (95% CI: 1.91-40.93, P = 0.005) and Frankel Grade C (95% CI: 1.12-14.54, P = 0.033).Conclusions: Admission size of the lesion, morphology, symptom duration, Frankel Grade and the presence of subarachnoid hemorrhage were strong outcome predictors regarding prognostication of neurological outcome in postoperative patients with SCMs. A decision to surgically remove a symptomatic SCM should be justified by systematic analysis of all factors potentially affecting outcome.
Higher Reinfection Rate after Two-stage Revision Arthroplasty in Patients with Refractory Diabetes Mellitus: A retrospective analysis with a minimum ten-year follow up
Authors: Lin Yu-Chih , Lin Yi-Hsuan , Chou Jian-Hong , Lo Yu-Tai , Chang Chih-Hsiang , Lee Sheng-Hsun , Lin Sheng-Hsuan
Published: August 2022

Background: Treatment protocols for two-stage revision arthroplasty with diabetes mellitus (DM) have not yet been established. The control of glycated hemoglobin (HbA1c) in two-stage revision arthroplasty is still debated. This study aimed to clarify the importance of preoperative HbA1c levels before each stage of revision arthroplasty and to analyze the risk factors for reinfection.Methods: 588 patients suffered from first-time PJI and was treated in our institute from January 1994 to December 2010 were reviewed. The mean follow-up time was 13.8 (range, 10.2–24.8) years. Patients underwent two-stage revision arthroplasty with DM at presentation were included. The endpoint of the study was reinfection of the revision arthroplasty. Demographic, survivorship, and surgical variables were also analyzed.Results: Eighty-eight patients were identified and grouped by HbA1c level before the first stage surgery: Groups 1 and 2 had HbA1c levels < 7% and ≥ 7%, respectively. Reinfection was identified in 4.55% (2/44) and 18.18% (8/44) of the patients in Groups 1 and 2, respectively. Survivorship analysis revealed correction of the HbA1c before the final stage of revision arthroplasty as an independent factor (p < 0.001). The identified risks for reinfection were HbA1c levels ≥ 7% before final-stage surgery, ≥ 3 stages of revision arthroplasty, and extended-spectrum beta-lactamase (ESBL)-Escherichia coli PJI.Conclusion: The HbA1c level before the final stage of revision arthroplasty could affect staged revision arthroplasty outcomes. Therefore, the necessity of postponing the elective final-stage revision arthroplasty procedure for HbA1c control should be further investigated in the future.
D-beta-hydroxybutyrate exhibits protective effects against microglia activation in lipopolysaccharide-treated mice and BV-2 cells
Authors: Zhang Yuping , Liu Kun , Li Yunpeng , Ma Yujie , Wang Yu , Fan Zihan , Li Yanning , Qi Jinsheng
Published: August 2022

Microglia activation is the key player in neuro-inflammation, which is the central process of neuro-disorders. The protective effects of D-beta-hydroxybutyrate (BHB) against microglia activation were evaluated in lipopolysaccharide (LPS)-treated mice and BV-2 cells. Behavioral test, morphological change and immunofluorescence of microglia marker ionizing calcium-binding adaptor molecule 1 (IBA-1) in the hippocampus, and the generation of inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and protective brain-derived neurotrophic factor (BDNF) and transforming growth factor-β (TGF-β) in the brain, were measured in LPS and/or BHB treated mice. In addition, the effects of BHB on the generation of IL-6, TNF-α, BDNF and TGF-β, and reactive oxygen species (ROS) level were detected in LPS-stimulated BV-2 cells. We found that BHB treatments attenuated behavioral abnormality of LPS-treated mice and reduced the number of IBA-1-positive cells with attenuation of cell morphological changes in the hippocampus. Meanwhile, BHB inhibited IL-6 and TNF-α generations; but promoted BDNF and TGF-β generations in the brain in LPS-treated mice. Furthermore, BHB concentration-dependently inhibited IL-6 and TNF-α generations, promoted BDNF and TGF-β generations, and reduced the level of reactive oxygen species with attenuation of cellular changes in LPS-stimulated BV-2 cells. In conclusion, BHB exhibits protective effects against microglia activation in LPS-treated mice and BV-2 cells, antagonizing neuro-inflammation.
Hybrid Intelligent Security Mechanism for Data Transmission among UPFs belonging to Different 5G Networks
Authors: Leu Fang-Yie , Lu Yu-Syuan , Liu Jung-Chun , Lin I-Long , He Rong-Tao , Dai Ning-Qi
Published: August 2022

Recently, 5G networks have gradually surrounded our living environments to color our everyday lives and make our daily activities more convenient than before. However, in 5G networks, packet P transmitted from local UPFA of a 5G network, e.g., 5G-A, to UPFB in P’s destination 5G network, e.g., 5G-B, is not secure, even not encrypted, particularly via the Internet, A ≠ B. This conducts a risk of data leakage along the connection established between UPFA and UPFB. To solve this problem, in this study, we propose an architecture that encrypts/decrypts P to prevent it from being attacked. P is encrypted by an edge computer, e.g., ECA in 5G-A before it is sent to its destination, and decrypted by another edge computer, e.g., ECB in 5G-B. In this paper, the scenario includes data transmission between two users or among n-party users, n > 2. For the former, the cryptography systems used are symmetric and asymmetric encryption/decryption approaches. For the n-party scheme, we adopt Initial Key Agreement (IKA) mechanism which employs Upflow and Downflow processes to establish a secret key for all participating ECs. Besides, message authentication code, and time stamp are also utilized to enhance the security level of data transmission. Our analyses show that this proposed approach can effectively avoid some types of attacks.
Interfacial shear strength of surface functionalized and functionalized CNT coated carbon fiber: A single fiber fragmentation study
Authors: Gogoi Rupam , Shankar Uday , Rawat Shweta , Manik Gaurav , Bandyopadhyay Anasuya
Published: August 2022

In this study, an effective surface functionalization of carbon fiber (CF) and its subsequent coating with functionalized carbon nanotubes (CNTs) were carried out to obtain improved interfacial shear strength (IFSS) which was validated by single fiber fragmentation test (SFFT). Functional groups, -COOH, -OH, and -NH2, were separately grafted on the CF surface using different chemical routes. Additionally, ultrasonic assisted electrophoretic deposition (EPD) technique was used to coat -COOH, -OH, and -NH2 functionalized CNTs on the sized and surface functionalized CFs. Attenuated total reflection-infrared spectroscopy (ATRIR), X-ray photoelectron spectroscopy (XPS), and field emission scanning electron microscopy (FESEM) images confirmed the successful surface functionalization and coating on CF. Neat PP and a blend of PP and maleic anhydride-grafted-styrene ethylene butylene styrene (MA-g-SEBS) were used as two different base polymer matrixes in preparing a total of 26 different SFFT samples. Silane functionalized CF coated with amine functionalized CNTs using ultrasonic assisted EPD process showed IFSS of ~ 29 MPa which was an impressive ~ 758% higher than pristine CF and highest among all the surface modified CFs. Interestingly, this translated into useful increase of ~ 13% in single fiber tensile strength of functionalized and treated CF over and above that of as received CF.
Synthesis and assessment of the cytotoxic effects of some of Novel Biginelli 3,4-dihydropyrmidine-2-(1H) one derivatives Containing 2-mercapto-3-phenyl-4(3H)-quinazolinone.
Authors: Nouri Mojtaba , Pirmohammadi Nasim , dilmaghani karim akbari , Pazhang Yaghub
Published: August 2022

In the present study, a new series of 3,4- dihydropyrmidine2-(1 H) one derivatives(4a-f) which linked to 2-mercapto-3-phenyl-4(3H)-quinazolinone were synthesized by using the nucleophilic substitution reaction of 2-mercapto-3-phenyl-4(3H)-quinazolinone (1) and an appropriate 6-bromomethyl-3,4- dihydropyrmidine2-(1 H) one (3a-f) in the presence of KOH as base and in CH3CN as solvent. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, 13C-NMR, Mass spectroscopy, and Elemental analysis. The cytotoxicity of the newly synthesized compounds was evaluated in vitro against the human breast cancer (MCF-7) cell line and human colon cancer cell line (HT-29) based on the results of the MTT assay. Our results indicated that the compound 4b exerted the most cytotoxic effect in the two cell lines and the IC50 values were (4.25±0.16 μM) for MCF-7 cell lines and (12.11±0.76 μM) for HT-29 cell lines. Also, compound 4b induced apoptosis more than other compounds in the two cell lines. Therefore, compound 4b may be a potential anticancer agent.
Development of a novel lipid metabolism-based signature to predict survival and immune response in triple negative breast cancer
Authors: Yang Xia , Tang Wen , He Yongtao , An Huimin , Wang Jin
Published: August 2022

Background
The high heterogeneity of triple negative breast cancer (TNBC) is the main clinical challenge for individualized therapy. Considering that fatty acid metabolism (FAM) plays an indispensable role in tumorigenesis and development of TNBC, we proposed a novel FAM-based classification to characterize the tumor microenvironment immune profiles and heterogeneous for TNBC.
Methods
Weighted gene correlation network analysis (WGCNA) was performed to identify FAM-related genes from 221 TNBC samples in Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset. Then, non-negative matrix factorization (NMF) clustering analysis was applied to determine FAM clusters based on the prognostic FAM-related genes, which chosen from the univariate/multivariate cox regression model and the least absolute shrinkage and selection operator (LASSO) regression algorithm. Then, a FAM scoring scheme was constructed to further quantify FAM features of individual TNBC patient based on the prognostic differentially expressed genes (DEGs) between different FAM clusters. Systematically analyses were performed to evaluate the correlation between the FAM scoring system (FS) with survival outcomes, genomic characteristics, tumor microenvironment (TME) features and immunotherapeutic response for TNBC, which were further validated in the Cancer Genome Atlas (TCGA) and GSE58812 datasets. Moreover, the expression level and clinical significancy of the selected FS gene signatures were further validated in our cohort.
Results
1860 FAM-genes were screened out using WGCNA. Three distinct FAM clusters were determined by NMF clustering analysis, which allowed to distinguish different groups of patients with distinct clinical outcomes and tumor microenvironment (TME) features. Then, prognostic gene signatures based on the DEGs between different FAM clusters were identified using univariate cox regression analysis and Lasso regression algorithm. A FAM scoring scheme was constructed, which could divide TNBC patients into high and low-FS subgroups. Low FS subgroup, characterized by better prognosis and abundance with effective immune infiltration. While patients with higher FS were featured with poorer survival and lack of effective immune infiltration. In addition, two independent immunotherapy cohorts (Imvigor210 and GSE78220) confirmed that patients with lower FS demonstrated significant therapeutic advantages from anti-PD-1/PD-L1 immunotherapy and durable clinical benefits. Further analyses in our cohort found that the differential expression of CXCL13, FBP1 and PLCL2 were significantly associated with clinical outcomes of TNBC samples.
Conclusions
This study revealed FAM plays an indispensable role in formation of TNBC heterogeneity and TME diversity. The novel FAM-based classification could provide a promising prognostic predictor and guide more effective immunotherapy strategies for TNBC.
Extracellular vesicles from biological fluids as potential biomarkers for prostate cancer
Authors: Choi Wendy Y. , Sánchez Catherine , Li Jiao Jiao , Dinarvand Mojdeh , Adomat Hans , Ghaffari Mazyar , Khoja Leila , Vafaee Fatemeh , Joshua Anthony M. , Chi Kim N. , Guns Emma S. Tomlinson , Hosseini-Beheshti Elham
Published: August 2022

Purpose
Despite the high incidence of false positives, prostate specific antigen (PSA) screening remains a widely used diagnostic test for prostate cancer, driving an urgent need for the discovery of better biomarkers for early prostate cancer detection. Extracellular vesicles (EV) secreted from cancer cells are present in various biological fluids, carrying distinctly different cellular components compared to normal cells, and have great potential to be used as a source of biomarkers.
Methods
EV from serum and urine of healthy men and prostate cancer patients were isolated, and characterised by transmission electron microscopy, particle size analysis, and western blot. Proteomic and cholesterol liquid chromatography-mass spectrometry (LC-MS) analyses were conducted.
Results
There was a successful enrichment of exosomes isolated from serum and urine. EV derived from biological fluids of prostate cancer patients had significant differences in composition when compared with those from healthy controls. Analysis of matched serum and urine samples from six prostate cancer patients revealed specific EV proteins common in both types of biological fluid for each patient.
Conclusion
Some of the EV proteins identified from our analyses have potential to be used as prostate cancer biomarkers, either to depict cancer progression or for disease diagnosis through non-invasive testing.
Institutionalization of Legal Culture
Authors: Shumkin Evgeny
Published: August 2022

The article features the conversion of public relations in the field of entrepreneurship through standardizing social and legal responsibilities. This process results from the evolutionary coordination of the social will for the rule of law and the state will to respect the rights and interests of society. Institutionalization is a natural development course of any social relations that are based on responsibility. It stimulates people to maintain the standard of rational behavior even in the case of rational ignorance. Legal culture is an aggregator of various implicit and transparent social codes. These codes can be evaluated from the point of view of sociological, philosophical, sociological-legal, axiological, political-legal, and activity approaches based on socio-systemic, phenomenological, cultural, economic, subcultural, managerial and axiological aspects. Institutionalization is an acceptable opportunity to convert social relations into a normative environment. It is a productive and logical way of social and economic development. The article introduces a new definition of legal culture, which highlights the admissibility of formalizing social relations through their institutionalization. The research made it possible to formulate the state reason to respect the best social practices and the public rejection of aggressive rule-making. Refusal to maintain the balance of interests may lead to latent opportunistic behavior of business entities and their unwillingness to follow the ideas of the official legal culture.
La Identidad Narrativa y su reflejo en el Habitar Poético: Arraigo Espacio-Temporal desde Paul Ricoeur y Martin Heidegger
Authors:   Pontificia Universidad Católica de Chile, Miranda Bascopé Christian Edwin
Published: August 2022

Esta investigación postula que la identidad narrativa ricoeuriana y el habitar poético heideggeriano se pueden complementar y potenciar recíprocamente para generar un arraigo que permita convivir adecuadamente con el mundo tecnológico científico. En el mundo contemporáneo todos los aspectos de la acción humana adquieren una dependencia casi total de la técnica y de sus estructuras de despliegue óntico. Dentro de este horizonte, cada faceta de la vida humana sufre una determinada modificación, y, por ende, una afectación existencial. De esta forma, nuestra vivencia espacio-temporal del mundo también es fundamentalmente modificada. Como herramienta metódica para desplegar el diálogo entre la identidad narrativa y el habitar poético, se tomará a la morada como lugar eminente para pensar el juego espacio-temporal de mundo desde donde el ser humano se reconoce. Con esta finalidad, en primer lugar, se describirá la manera en que el arraigo del habitar poético y la identidad narrativa reiteran, a su manera, nuestro sí mismo en el nivel ontológico existencial. En segundo lugar, se especificarán algunas modalidades de afectación espacio-temporales provocadas por los cambios tecnológico-científicos de nuestra era. Finalmente, como objetivo fundamental, se pretende generar una comprensión amplia de la reciprocidad entre la identidad narrativa y el habitar poético; mostrando su potencial relación dinámica, conceptual y de co-potenciación.
El origen del mundo: una azarosa adaptación o un diseño inteligente.a mirada desde la quinta vía de Tomás de Aquino
Authors:   Pontificia Universidad Católica de Chile, Velarde Lizama Catalina
Published: August 2022

En este artículo se estudiará la quinta vía de Tomás de Aquino, en diálogo con dos teorías del origen del universo: la que sostiene que todo surge del azar y la adaptación, y aquella que afirma desde la biología que es posible aceptar las causas inteligentes en la naturaleza, en vista a órganos muy específicos y complejos que se encuentran en ella. Esta última postura concuerda mejor con la quinta vía que la primera, aunque hay seguidores de Tomás de Aquino que admiten una evolución moderada, es decir, que no implique transformación de una especie a otra.
PENDAMPINGAN PENULISAN PROPOSAL UNTUK KOMPETISI INOVASI BISNIS MAHASISWA (KIBM) TAHUN 2020 DI UNIVERSITAS PGRI WIRANEGARA
Authors: MABAROH BAROTUN , . Daryono , Indarti Nunuk , Rosidah Ilmiyatur , Nurmalitasari Dewi
Published: August 2022

Guna mendukung peran sebagai agen pertumbuhan ekonomi disamping penguasaan akademiknya, mahasiswa harus memiliki kemampuan dalam menulis proposal bisnis yang baik. Apalagi, Pusat Prestasi Nasional selalu mengundang mahasiswa untuk mengikuti Kompetisi Inovasi Bisnis Mahasiswa (KIBM). Program ini bertujuan untuk mendorong mahasiswa agar menghasilkan inovasi dalam berbisnis yang nantinya dapat menjadi kelangsungan hidupnya. Sayangnya, mahasiswa Universitas PGRI Wiranegara belum pernah mengetahui dan berpengalaman mengajukan proposal bisnis apapun termasuk untuk program KIBM yang diselenggarakan oleh Pusat Prestasi Nasional. Oleh karena itu, tim di sini melakukan pelatihan dan pemantauan intensif bagi para mahasiswa untuk menulis proposal bisnis yang berharga hingga berhasil diunggah ke dalam sistem KIBM. Program ini dilakukan selama 24 hari didukung oleh Pusat Pengembangan Bisnis (P2B) Universitas PGRI Wiranegara. Tiga puluh empat mahasiswa mengikuti program ini. Mahasiswa dikelompokkan di Whatsapp, dan menghasilkan 10 proposal yang telah diunggah untuk KIBM 2020
Elevation based Flood-Susceptibility Mapping of the Pirojpur District using Remote Sensing and GIS
Authors:   Department of Agroforestry & Environmental Science, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh, Shapla Tarulata
Published: August 2022

Mapping the flood-susceptibility is crucial in organizing and effectively planning for flood prevention. This study focused on mapping possible flood-susceptibility areas in Pirojpur, Bangladesh using SRTM elevation data and GIS by combining four flood-influencing factors: elevation, slope, topographic wetness index (TWI) and drainage density. The results showed that the district is mostly under medium-risk (27%) of flooding, however, all of the sub-districts have areas that fall under the high (26% total of the district) to very high-risk (24% total of the district). To reduce the impact on society, it is essential to be prepared for natural hazards. The approach taken in this study will be helpful to the local authorities and the policymakers in assisting in making effective flood mitigation strategies and reducing the threats associated with floods. Keywords: Flood susceptibility, Flood management, SRTM, GIS.
Comparación de irregularidades en brackets de cuatro sistemas de ligado convencional y un sistema de autoligado
Authors: Alvarado Torres Emerik , Cruz López María Fernanda , Gutiérrez Rojo Jaime Fabián , Rojas García Alma Rosa
Published: August 2022

El éxito en el movimiento de ortodoncia está directamente relacionado con la habilidad de deslizamiento de los arcos en el slot de los brackets y tubos. El contacto entre el arco y la superficie del slot nos produce una fricción la cual es definida como un conjunto de fuerzas que actúan sobre el diente oponiéndose al movimiento dentario. Objetivo: Comparar las irregularidades presentes en brackets y slot de cuatro sistemas de ligado convencional y de un sistema de autoligado. Material y métodos: Se realizó la observación con un microscopio digital de 75 brackets, 15 de cada casa comercial, se tomó una captura de la imagen observada, fueron evaluadas por 4 observadores, quienes registraron irregularidades observadas en base y slot de cada bracket, para su comparación porcentual. Resultados: Los brackets de autoligado presentan el porcentaje de irregularidades menor tanto en el total de sus superficies como en el slot
Manejo de retenciones en paciente con displasia cleidocraneal
Authors: Domínguez Rivera Andrea , Tafoya Barajas Ulises , Villanueva Moreno Norma , Canseco López Joaquín , Almudena Cervantes María
Published: August 2022

La displasia cleidocraneal es una enfermedad poco frecuente y se caracteriza por la interrupción en el desarrollo óseo, la cual limita la exfoliación de los dientes deciduos, por lo que la dentición permanente no puede erupcionar y conlleva a afecciones estéticas y funcionales. El presente caso clínico describe a una paciente con displasia cleidocraneal atendida en el Hospital Infantil de México «Federico Gómez», la cual recibió tratamiento para varios dientes retenidos, asociados con la enfermedad de base, evitando la extracción de dientes incluidos y sin manejo protésico; tratada con exposición de los dientes incluidos, mejorando la oclusión por medio de exposición quirúrgica con tracción dental y tratamiento de ortodoncia. En este reporte de caso, se hace énfasis en la biomecánica utilizada para agilizar la tracción dental y obtener resultados óptimos
Tratamiento de supernumerarios en zona anterosuperior. Presentación de un caso
Authors: Torres Armas Lena , Llanes Rodríguez Maiyelín , Batista González Nurys Mercedes
Published: August 2022

Introducción: Los dientes supernumerarios se producen como resultado de alteraciones durante las fases de inicio y proliferación del desarrollo dental. La presencia de cualquiera de ellos puede ocasionar retención de los dientes permanentes. Objetivo: Con el propósito de mostrar la importancia del diagnóstico y tratamiento precoz de esta alteración, se presenta un caso donde, de manera sencilla, se eliminan los supernumerarios y se logra el brote del diente retenido. Presentación del caso: Paciente masculino de ocho años, con presencia de dientes suplementarios y retención del 11, al cual se le realiza la exodoncia de los supernumerarios, y con placa de Hawley y elásticos se logra armonía oclusal. Conclusiones: A través de un diagnóstico certero y un tratamiento sencillo, se pueden evitar complicaciones oclusales posteriores y mejorar la estética del niño.
Atención de paladar hendido y alteraciones craneofaciales en México
Authors: Ayuso Arce América , Villaseñor Caloca Rafael
Published: August 2022

Es nuestro interés, hablar sobre la evolución de la visión y misión, en la atención de labio y paladar hendido y alteraciones craneofaciales en México; requerimos de un marco de referencia de las inagotables posibilidades que pueden desarrollarse y establecer una fuente de vanguardia profesional a nivel nacional e internacional.
Prevalencia de segundos molares permanentes impactados en la Clínica de Ortodoncia de la DEPeI, FO, UNAM
Authors: Ramírez Juan de Dios Marcelino , Hernández Girón Fabiola , Meléndez Ramírez Arcelia
Published: August 2022

La impactación es definida como una falla en la erupción dental causada por un obstáculo físico. Las alteraciones en la erupción de los segundos molares permanentes se han reportado como bastante raras. Objetivo: Determinar la prevalencia de impactación de segundos molares permanentes, en pacientes que solicitaron atención al Servicio de Ortodoncia durante el periodo de agosto de 2015-junio de 2017. Material y métodos: Se revisaron 2,968 radiografías panorámicas y se identifi caron 31 pacientes que presentaban segundos molares permanentes impactados, de las cuales se obtuvo una muestra de 41 segundos molares impactados. Con la información obtenida se determinó la prevalencia por edad, sexo, biotipo facial y clase esquelética, de igual forma se recabó información que permitió identifi car la frecuencia en relación con cada uno de los cuadrantes. Resultados: La prevalencia de segundos molares permanentes impactados es del 1.4%; la distribución por sexo demuestra que la mayor prevalencia corresponde al sexo femenino (53.7%) y para el masculino la prevalencia fue del 46.3%. Conclusiones: La relación con el biotipo facial y la clase esquelética infl uye directamente en la prevalencia de impactación al igual que los factores locales como el desarrollo y posición del tercer molar, el espacio entre la superfi cie distal del primer molar y el borde anterior de la rama mandibular, así como el desarrollo y tipo de crecimiento de la mandibular.
Protracción maxilar apoyada en miniplacas de fi jación quirúrgica en pacientes con secuelas de hendiduras labio palatinas. Reporte de seis casos
Authors: Ayuso Arce América , Pong Tejeda Carlos , González González Ricardo , Vite Silva Armando , Vargas Rosales Manuel
Published: August 2022

Reporte de seis casos de protracción maxilar soportada con miniplacas quirúrgicas de fijación rígida en pacientes con diagnóstico secuelas de LPH unilateral y bilateral, con edad promedio de 13.4 años, y distribuidos en cuatro casos unilaterales y dos bilaterales. La utilización de elásticos intermaxilares sin apoyo extraoral es una ventaja sobre la máscara de protracción, por la constancia de las fuerzas, y las horas de uso que se aumentan por la comodidad del paciente; las estructuras óseas son estimuladas efectivamente minimizando la compensación dentoalveolar obteniendo adelantamiento del punto A maxilar, de 6 mm en promedio, con modifi cación del centro facial mejorando la relación esquelética y dental así como la autoestima de los pacientes. El sexto paciente bilateral fue descartado debido a que no se logró osteointegrar el material de osteosíntesis, condicionando que se afl ojaran las placas, lo que no permitió la protracción, no se presentaron complicaciones con el material de osteosíntesis. Estudio realizado en las instalaciones de la UNITEC.
Tratamiento ortodóncico quirúrgico de paciente con asimetría facial debido a hiperplasia condilar. Presentación de caso clínico
Authors: Caro Lozano María Guadalupe , Sánchez Valverde Alfredo
Published: August 2022

El objetivo de este reporte es presentar la corrección de un caso de asimetría facial con hiperplasia condilar. Se presenta el caso clínico de paciente femenino de 19 años que acude al Departamento de Ortodoncia de la Facultad de Odontología de la Universidad Nacional Autónoma de México, sin datos patológicos aparentes. Se observa asimetría facial por desviación mandibular hacia el lado izquierdo. Intraoralmente muestra ligero apiñamiento dental, líneas medias dentales no coincidentes, arcadas ovaladas, agenesia de OD 15, clase III molar y canina bilateral y mordida cruzada anterior y posterior izquierda. El diagnóstico cefalométrico mostró clase III esquelética por prognatismo, patrón de crecimiento vertical; canteamiento maxilar, desviación mandibular. El tratamiento fue ortodóncico quirúrgico en tres fases: 1. Ortodoncia prequirúrgica con aparatología Roth 0.022”; 2. Quirúrgica, avance e impactación unilateral del maxilar, osteotomía vertical bilateral para la corrección de prognatismo y laterognasia y avance del mentón; 3. Ortodoncia post quirúrgica, detallado, consolidación y asentamiento. El tratamiento tuvo una duración de 23 meses, donde se logró corregir la asimetría facial, se eliminó la mordida cruzada, conseguimos clase I canina y molar bilateral, se centraron las líneas medias dentales, mejorando la función y la estética de la paciente.