bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of GLUT2 rs8192675, MATE1 rs2289669, and OCT2 rs316019 Genetic Polymorphism on Metformin Efficacy and Glycemic Control in Type 2 Diabetes Mellitus Patients
Authors: Raza Muhammad Kashif , Aamir Aziz-ul-Hasan , Mansour Lamjed , Khan Zahid , Shahwar Durr-e- , Ali Aktar , Imran Muhammad
Published: February 2024

Metformin, being the gold standard drug of choice in type 2 diabetes mellitus (T2DM) shows differential therapeutic response in patients due to gene polymorphism. The objective of this study was to investigate the influence of GLUT2 rs8192675, MATE1 rs2289669, and OCT2 rs316019 being hotspot single nucleotide polymorphisms (SNPs) on metformin efficacy and glycemic control in T2DM. In current research work, 417 subjects were enrolled, of which 200 were healthy control, and 217 newly diagnosed T2DM patients, involving 60 metformin non-responding and 157 metformin responding individuals. The patients were subjected to three months of metformin monotherapy and their initial and final HbA1c, BMI, fasting glucose, and lipid profiles were determined. Genotyping was performed through real-time PCR with melt curve analysis followed by agarose gel electrophoresis and Sanger sequencing. GLUT2 rs8192675 CC genotype (OR 0.24, CI 95% 0.06–0.84, p = 0.02) and MATE1 rs2289669 A allele (OR 0.14, CI 95% 0.05–0.33, p < 0.0001) were significantly associated with metformin response and glucose-lowering effect. No significant association ( p > 0.05) was observed for OCT2 rs316019. GLUT2 rs8192675 CC genotype and MATE1 rs2289669 A allele are significantly associated with low glucose and HbA1c levels, positively altering metformin efficacy in newly diagnosed T2DM responsive individuals.
Physical map of QTLs for some agronomic traits across many environments, identification of related candidate genes, and development of KASP markers with emphasis on terminal heat stress tolerance in common wheat
Authors: Kumar Sourabh , Kumar Sachin , Sharma Hemant , Singh Vivudh Pratap , Rawale Kanwardeep Singh , Kahlon Kaviraj Singh , Gupta Vikas , Bhatt Sunil Kumar , Vairamani Ramanathan , Gill Kulvinder Singh , Balyan Harindra Singh
Published: February 2024

To understand the genetic architecture of important agronomic traits under heat stress, we used a doubled-haploid (DH) mapping population (177 lines) derived from a heat sensitive cultivar (PBW343) and a heat tolerant genotype (KSG1203). This population was evaluated for 11 agronomic traits under timely (optimum), late (mild heat stress), and very late sown (heat stress) environments over two locations and three years totalling 15 environments. Best linear unbiased estimates for each trait and a sequencing based genotyping (SBG) SNP genetic map comprising 5,710 markers were used for composite interval mapping of QTLs. The identified 66 QTLs were integrated into a physical map (5,710 SNPs; 14,263.4 Mb) of wheat. The 66 QTLs (20 novel QTLs) each explained 5.3–24.9% of the phenotypic variation. Thirteen stable QTLs each with high PVE were recommended for marker-assisted recurrent selection (MARS) for optimum and heat stress environments. Selected QTLs were validated by their presence in high yielding DH lines. Three QTLs for 1000-grain weight were co-localized with known genes TaERF3-3B, TaFER-5B, and TaZIM-A1; a QTL for grain yield was co-localized with TaCol-B5, and gene TaVRT-2 was associated with traits related with some of the QTLs for spike traits. Specific known genes for several traits including thermostability, enhanced grain yield etc. were co-located with the QTLs. Furthermore, 61 differentially expressed candidate genes for heat tolerance in plants that encode 28 different proteins were identified. KASP markers for three major/stable QTLs were developed for MARS focussing on the development of heat tolerant wheat varieties and germplasm.
Benthic response to the strong Silurian climatic fluctuations – implications from Gotland (Sweden)
Authors: Claussen Anna Lene , Munnecke Axel
Published: February 2024

Climatically the Silurian was a most unstable period, as it is shows several strong d13C excursion, with the Lau excursion being the strongest short-lived positive d13C excursion of the entire Phanerozoic. The causes of these excursions are still debated. In order to determine how benthic communities responded to these climatic perturbations, a microfacies analysis of carbonate rocks from the Silurian (Late Telychian to the uppermost Ludfordian) of the Gotland was carried out. Reef development was strongly enhanced during periods with carbon isotope excursions, compared to time intervals without. In times of very high d13C values (≥ 3‰) bryozoans and microbes become more abundant and, in some areas, form reefs (Bryostromatolites), while corals and stromatoporoids were the main reef builders in periods of lower isotope ratios (0–3‰). In addition, a significant increase of phosphatic components, gypsum pseudomorphs and the microproblematicum Palaeomicrocodium is observed in times of increased isotope ratios. A model is proposed explaining the changes in the benthic communities over time. It is based on previously published models which assume climatic shifts from humid to arid climate but adds phosphorous in sea water as an important factor for the development of the benthic communities.
The Firefly Sparkle: The Earliest Stages of the Assembly of A Milky Way-type Galaxy in a 600 Myr Old Universe
Authors: Mowla Lamiya , Iyer Kartheik , Asada Yoshihisa , Desprez Guillaume , Tan Vivian Yun Yan , Martis Nicholas , Sarrouh Ghassan , Strait Victoria , Abraham Roberto , Bradac Marusa , Brammer Gabriel , Matharu Jasleen , Muzzin Adam , Ravindranath Swara , Willott Chris , Sawicki Marcin , Estrada-Carpenter Vince , Noirot Gael , Rihtaršič Gregor , Zabl Johannes , Jahan Nusrath , Pacifici Camilla
Published: February 2024

The most distant galaxies detected by JWST are assembling in a Universe that is less than 5% of its present age. At these times, the progenitors of galaxies like the Milky Way are expected to be about 10,000 times less massive than they are now, with masses quite comparable to that of massive globular clusters seen in the local Universe. Composed today primarily of old stars and correlating with the properties of their parent dark matter halos, the first globular clusters are thought to have formed during the earliest stages of galaxy assembly. In this article we explore
the connection between globular clusters and galaxy assembly by showing JWST observations of a galaxy at zspec = 8.304 ± 0.001, strongly lensed by a massive foreground cluster of galaxies, exhibiting a network of massive star clusters (the ‘Firefly Sparkle’) cocooned in a diffuse arc. The Fire-fly Sparkle exhibits the hallmarks expected of a future Milky Way-type galaxy captured during its earliest and most gas-rich stage of formation. The mass distribution of the galaxy seems to be concentrated in ten distinct clusters (∼ 49 − 57% of the total mass), with individual cluster masses (M∗,cluster ∼ 105.3 − 105.8M⊙) that straddle the boundary between low-mass galaxies and high-mass globular clusters. The cluster ages suggest that they are gravitationally bound with star formation histories showing a recent starburst possibly triggered by the interaction with a companion galaxy at the same redshift at a projected distance of ∼2 kpc away from the Firefly Sparkle. The central star cluster shows nebular-dominated spectra consistent with high temperatures (Te ∼ 40, 000K) and a top-heavy initial mass functon(0.78 < α < 2.0), the product of formation in a very metal poor environment. Combined with abundance matching that suggests that this is likely to be a progenitor of galaxies like our own, the Firefly Sparkle provides an unprecedented case study of a Milky Way-like galaxy in the earliest stages of its assembly in only a 600 million year old
Universe
The Association between Composite Dietary Antioxidant Index and Cognitive Impairment in the American Elderly: A Cross-Sectional Study (NHANES 2011-2014)
Authors: Yang Hang , Wang Xiaoying , Zhou Ye , Zhang Shenyingjie , Gao Zhenzhen
Published: February 2024

Background
Oxidative stress is involved in the development and progression of cognitive impairment. However, the association between composite dietary antioxidant index (CDAI) and cognitive impairment remains unknown.
Objective
This cross-sectional study was to investigate the association between CDAI and cognitive impairment among the American elderly.
Methods
The public data was available from the United States National Health and Nutrition Examination Survey from 2011 to 2014. Participants aged ≥ 60 years were eligible for cognitive function, including word learning and recall modules from the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), the animal fluency test (AFT), and the digit symbol substitution test (DSST). A composite cognition score was created to evaluate global cognition. The univariate and multivariate logistic regression analysis, restricted cubic spline, stratified and sensitivity analysis were conducted.
Results
CDAI was negatively associated with cognitive impairment. For each standard deviation increase in CDAI, the risk of cognitive impairment decreased by 6% for DSST (OR = 0.94, 95% CI: 0.9, 0.97), 7% for AFT (OR = 0.93, 95% CI: 0.9, 0.96), 4% for CERAD (OR = 0.96, 95% CI: 0.93, 0.99), and 7% for global cognition (OR = 0.93, 95% CI: 0.9, 0.96) after adjusting for multiple potential confounders. This significant negative relationship remained consistent when comparing individuals in the highest CDAI tertile with those in the lowest CDAI tertile. Furthermore, a non-linear relationship was observed between CDAI and cognitive impairment on AFT (P for non-linearity = 0.009) and global cognition (P for non-linearity = 0.006).These negative correlations between CDAI and cognitive impairment were observed across the stratified age, gender, poverty-to-income ratio, body mass index, hypertension, and diabetes. However, the interaction test revealed significance for education on DSST (P for interaction = 0.04). Moreover, vitamin E, zinc, selenium, and carotenoids were independently associated with cognitive impairment in this study. The sensitivity analysis for participants with complete covariates yielded a similar finding.
Conclusion
These findings suggested a negative and non-linear association between the CDAI and the risk of cognitive impairment among the American elderly. The results have significant implications for public health initiatives to prevent and limit the progression of cognitive impairment through dietary interventions.
IoT-Based Intelligent Charging System for Kayoola EVs Buses at Kiira Motors Corporation in Uganda
Authors: Ntwali Benjamin , Sinde Ramadhan , Ally Mussa , Naman Godfrey , NTAMBARA Boniface
Published: February 2024

The increasing popularity of Electric Vehicles (EVs) has led to a surge in the need for charging stations in Kayoola EV buses. Most of existing EV charging stations have outdated features which is challenging to be remotely controlled. However, current EV charging systems experience with no remote battery operational charging status, unsafety control if charging station is faulted, and insecure charging RFID card payment. This paper, an IoT-based system was aimed to manage and monitor these EV charging stations. The battery management system (BMS) sends charging voltage and current information to charger via Controller Area Network (CAN) bus. Then, the Raspberry Pi4 receives and decode CAN charging data to be processed, analyzed and transmits to the cloud server. Each charger is equipped with sensors monitoring parameters like charging status, energy consumption, voltage, current, and time. The user can access that decoded charging information via android mobile application and desk remote management system. Additionally, the system server calculates the battery charging levels and commend RFID card transaction payment. The results show that developed IoT-based intelligent charging system provides and outperforms minimum and maximum cell voltages of 2.82V and 4.1V, min. and max. cell temperatures of 37℃ and 40℃ respectively. The charged energy of 10kWh, used energy of 0kWh, charging state indication, low-cell voltage as error state indication, charging price rate of 500Ugx/kWh, and full-latch of 0, pack voltage of 483.9V, pack current of 100.1A, battery health of 97%, battery state of charge (SoC) of 100% and remaining charging time of 38 mins were also detected and remotely monitored. In conclusion, the developed system proves 100% of real-time and remote data access and accuracy, efficiency, security, accessibility, sustainability, safety charging payment, and remote battery status monitoring system of EV charging infrastructure compared to the current charging where it offers only 58.75% of charging rate.
Pulmonary fibrosis in critically ill patients with COVID-19: A multi-center retrospective cohort study in South Korea
Authors: Cho Dae Hong , Chae Ganghee , Joh Joon-Sung , Kim Junghyun , Park Tae Yun , Baek Ae-Rin , Kim Won-Young , Jegal Yang Jin , Chung Chi Ryang , Lee Jinwoo , Park Joo Hun , Lee Jae Wook , Lim Soyeoun , Song Jin Woo
Published: February 2024

Background: Pulmonary fibrosis persists long after recovering from coronavirus disease 2019 (COVID-19) infection, thereby reducing quality of life and lung function. We aimed to evaluate the prevalence and risk factors for pulmonary fibrosis in patients with severe COVID-19 pneumonia requiring mechanical ventilation, a high-risk group for developing pulmonary fibrosis.
Methods: Clinical data and chest computed tomography (CT) scans of patients with severe COVID-19 pneumonia requiring mechanical ventilation were retrospectively collected from nine hospitals in South Korea. Fibrotic-like changes on chest CT were visually assessed.
Results: We included 125 patients with a mean age of 68.5 years, 60.8% men and 7.2% having underlying lung disease. Based on follow-up chest CT (the median interval: 38.0 days, interquartile range: 24.0–68.0 days), 94 (75.2%) patients exhibited fibrotic-like changes, with traction bronchiectasis and/or bronchiolectasis being the most common change (60.8%). Adjusted Cox regression analysis revealed as association between hemoglobin levels ≤9 g/dL and an increased risk of pulmonary fibrosis development (HR: 3.182, 95% Cl: 1.203–8.415, P=0.025). Among all patients, 17.6% died during hospitalization and 71.2% experienced complications, including intubation-related airway injury (12.8%), ventilator-associated pneumonia (44.8%), lung injury (11.2%), and hemodynamic disturbance (33.4%). In-hospital mortality (16.1% vs. 18.1%) and complications (67.7% vs. 72.3%) were similar between patients with and without fibrotic-like changes.
Conclusion: Our study demonstrated that in patients with severe COVID-19 pneumonia requiring mechanical ventilation, chest CT revealed fibrotic-like changes in approximately three-fourths of patients. Low hemoglobin levels might be associated with pulmonary fibrosis in severe COVID-19 pneumonia.
Hybrid and Effective Model for the Prediction of Diabetes
Authors: Tripathy Niva , Pande Sohan Kumar , Das Satyabrata
Published: February 2024

The most widely studied research area in healthcare is healthcare systems using modern integrated computing techniques. A lot of data is generated from innu- merable heterogeneous healthcare sensors, IoT devices, and monitoring devices. Collecting, organizing, understanding, and forecasting patient health is extremely important. In this research paper, a smart healthcare recommendation system, namely, Hybrid and Effective Prediction of Diabetes (HEPD), is proposed. HEPD uses data fusion techniques and machine learning methods to predict and recom- mend treatment for diabetes and other life-threatening diseases more accurately. It is an intelligent recommendation system that is trained to predict diabetes. For in-depth evaluation of this HEPD model, it is simulated and examined on estab- lished heterogeneous datasets. The outcome of the simulations is analogized with the most recent development and existing models. From the comparison results, it is found that the HEPD achieves 91.5% accuracy, which is much higher than the renowned machine learning methods.
Evaluating Three Pakistani Soybean Cultivars for High-Temperature Tolerance
Authors: Nadeem Muhammad , khan Aqsa , Khurshid Haris , Jabeen Zahra , Farrakh Sumaira , Haider Waseem
Published: February 2024

Background Soybean (Glycine max) is oil seed crop and grown world widely, It seedlings might encounter varying temperature conditions in both early and conventional soybean production methods. The suitable optimum temperature for soybean cultivation is 30/22 ºC.
Methods and Results Considering climate temperature changes in the world, a study was conducted to quantify the performance of three major Pakistani soybean cultivars at high temperature (HT; 40/25ºC) during the seedling growth stage. The performance was accessed in term of morphological features, biochemical parameters, antioxidant enzyme activity assays and expression analysis of stress related genes. For all parameters, leaf samples were collected at 32 Days After Sowing (DAS). The results showed that Germination Percentage (GP) was high in NARC-II and RAWAL-I with earlier Days to Flower Initiation (DFI) and Days to Maturity (DM) as compared to SWAT-84. NARC-II showed smaller Plant Height (PH), Number of Branches per Plant (NBP) and Pods per Plant (PP) as compared to other cultivars. Seed Yield, Total Soluble protein (TSP), and Total chlorophyll was recorded high for NARC-II as compared to other cultivars, while carotenoids content was also observed higher in NARC-II as compared to RAWAL-I and SWAT-84.Antioxidant enzymatic activity for POD and SOD activity was observed higher in SWAT-84 among cultivars. Relative expression of peroxidase (GLYMA_19G148800) gene and lipoxygenase (GLYMA_13G239000) indicates that NARC-II has the highest expression followed by RAWAL-I and SWAT-84.
Conclusions This is pilot study to explore tolerance of high temperature among the NARC-II, RAWAL-I and SWAT-84 cultivars.
Spatiotemporal Analysis of Soil Moisture Drought in the Horn of Africa
Authors: Alasow Ahmed Abdiaziz , Hamed Mohammed Magdy , Rady Mohammed , Arab Mohamed Abdillahi , Muhammad Mohd Khairul Idlan , Shahid Shamsuddin
Published: February 2024

Droughts continuously threaten human life, livestock, and agriculture across the Horn of Africa (HOA). As climate change exacerbates drought frequency and severity, accurately quantifying spatiotemporal drought patterns is critical to developing evidence-based policies that mitigate impacts and build resilience among vulnerable communities. This study conducted a spatiotemporal analysis of soil moisture drought over the HOA, utilizing high-resolution ERA5 reanalysis data between 1951 and 2020. The Standardized Precipitation Evapotranspiration Index (SPEI) was calculated at 3-, 6-, 9-, and 12-month timescales to identify historical drought events and assess drought duration and intensity changes over 70 years. Spatial analysis revealed decreasing soil moisture levels across HOA, with the most substantial reductions of 45% occurring in Djibouti and Northern Somalia. Comparisons between the baseline period (1951-1985) and the recent period (1986-2020) showed increasingly negative SPEI intensities, indicating a shift towards drier conditions, especially in Somalia, Kenya, and Ethiopia. The results also pointed to rising frequencies of moderate droughts by around 15% and severe droughts by 5-10% from 1986 to 2020 in the baseline period. The findings can inform policy to improve regional drought monitoring systems and the development of climate-resilient agriculture strategies, water resource management, and disaster risk reduction planning to protect lives and food security.
Comparative analysis of a novel robust Fuzzy control algorithm, MPC and PID controllers for an uncertain two-link planar manipulator robot with external disturbances
Authors: Abadi Ali Soltani Sharif , Hameed Ayesha , Hosseinabadi Pooyan Alinaghi , Ordys Andrew , Adouane Lounis
Published: February 2024

This paper presents a novel robust Fuzzy controller for a planar manipulator robot. Also, the Model Predictive Control (MPC) and PID techniques are used to compare the results with the proposed method. The control system of the manipulator robots must have some special features that guarantee stability, fast tracking, practicability of the control signals, smooth control, etc. A comparative analysis can provide a clearer picture of the control system’s performance. This study presents a comparative analysis between a novel robust Fuzzy technique, MPC and PID controllers for a two-link planar manipulator robot. Simulink/MATLAB is used for simulations of the controllers. The results show that the proposed robust Fuzzy method performs better and is more robust than other methods. The Integral of the Absolute value of the Error (IAE) and Integral of the Time Absolute value of the Error (ITAE) performance indexes are employed for a better and more logical comparison. Moreover, the control methods are compared with the essential control features such as accuracy, fast-tracking, robustness, etc. And in all the features, the proposed Fuzzy method is better than others.
Genetic liability for smoking and risk of hepatocellular carcinoma: a two-sample Mendelian randomization study
Authors: Wang Shu-chao , Tian Nan-nan , Peng Lei
Published: February 2024

Objective: Observational studies have yielded conflicting results on the association of smoking with the risk of hepatocellular carcinoma (HCC). This study used Mendelian randomization (MR) design to estimate the causal effect of smoking on the risk of HCC.
Methods: We used the two-sample MR framework mainly with inverse-variance weighted (IVW) method to estimate the causal effect of genetic liability for smoking on HCC. Complementary sensitivity analyses were conducted to test the robustness of our results. Genome-wide association studies (GWAS) that were based on predominantly European and East Asian ancestry. The sample sizes of the GWAS used in this study ranged from 197,611 to 468,170 participants. This study retrieved and extracted genetic variants associated with smoking and their corresponding summary-level information in HCC from the respective GWAS.
Results: All of the results from IVM, IVW radial, IVW with multiplicative random effects, MR-Egger regression, and the weighted median methods demonstrated that genetically predicted smoking was significantly associated with higher odds of HCC, with odds ratios (ORs) of 2.47 (95%CI, 1.22–5.17; P = 0.017), 2.49 (95%CI, 1.19–4.76; P = 0.008), 2.53 (95%CI, 1.30–4.51; P = 0.005), 3.69 (95%CI, 1.36–6.25; P = 0.035) and 1.93 (95%CI, 1.06–3.94; P = 0.049), respectively.
Conclusions: Our study provided potential evidence between genetically predicted smoking and HCC.
Management of Oronasal Fistula using L-PRF and Palatal Flap due to Residual Cyst in Maxilla: A Case Report
Authors: Fares Raissa Dias , De-Moraes Sylvio Luiz Costa , Silva Jonathan Ribeiro da
Published: February 2024

Objective
This paper aims to present a case report of a female patient who intended for dental implants but was referred to the maxillofacial surgery department presenting a cone beam computed tomography with incidental finding in the anterior part of the maxilla.
Methods
The first surgical procedure consisted of the resection of the lesion associated with bone graft with buccal fat pad flap and posterior histopathological study. After three months the patient developed an oronasal fistula. During the second surgical management, the authors chose platelet concentrates (L-PRF) to fill the bone defects associated with the palatal flap.
Results
After 6 months of follow-up, the patient presented definitive soft tissue healing, no exposure of bone tissue, and the closure of oronasal communication. The new CT scan and panoramic x-ray showed satisfactory bone healing.
Conclusion
The present study demonstrated the association of L-PRF with xenograft and palatal flap can be a viable method for the management of patients with oronasal fistula. This report adheres to the SCARE guidelines for the reporting of surgical cases in medical literature.
IRIME: A Novel Approach to Mitigating Exploitation-Exploration Imbalance in Rime Optimization Algorithm for Feature Selection
Authors: Huang Jinpeng , Chen Yi , Heidari Ali Asghar , Liu Lei , Chen Huiling , Liang Guoxi
Published: February 2024

Rime optimization algorithm (RIME) is an emerging metaheuristic algorithm. However, RIME encounters issues such as an imbalance between exploitation and exploration, susceptibility to local optima, and low convergence accuracy when handling problems. To address these drawbacks, this paper introduces a variant of RIME called IRIME. IRIME integrates the soft besiege (SB) and composite mutation strategy and restart strategy (CMS-RS), aiming to balance exploitation and exploration in RIME, enhance population diversity, improve convergence accuracy, and endow RIME with the capability to escape local optima. To comprehensively validate IRIME's performance, IEEE CEC 2017 benchmark tests were conducted, comparing it against 13 conventional algorithms and 11 advanced algorithms, including excellent algorithms in the CEC competition such as JADE. The results indicate that the performance of IRIME is the best. To validate IRIME's practical applicability, the paper proposes a binary version, bIRIME, applied to feature selection problems. bIRIMR performs well on 12 low-dimensional datasets and 24 high-dimensional datasets. It outperforms other advanced algorithms in terms of the number of feature subsets and classification accuracy. In conclusion, bIRIME performs notably well in feature selection, particularly in high-dimensional datasets.
Comprehensive analysis of Linc01436 for neoadjuvant chemotherapy response and its potential enriched pathways in breast cancer
Authors: Li Ye , Sheng Xiaonan , Dai Huijuan , Wang Yaohui , Zhou Liheng , Yin Wenjin , Lu Jinsong
Published: February 2024

Background
Linc01436 is a novel long non-coding RNA which is associated with tumor proliferation and progression, but its involvement in breast cancer development and neoadjuvant chemotherapy (NAC) response has not been reported. Here, we aimed to explore the association between Linc01436 expression and NAC response as well as their survival outcome in breast cancer patients, and to identify the potential molecular mechanisms of Linc01436 involved in breast cancer.
Materials and Methods
Univariate and multivariate logistic regression, ROC were used to verify the predictive value of Linc01436 expression in pCR after NAC. Kaplan–Meier curve was utilized to examine the prognostic impact of Linc01436. The Kyoto Encyclopedia of Gene and Genome (KEGG) analysis and Gene Set Enrichment Analysis (GSEA) were conducted to determine the biological processes that Linc01436 may participate in. CIBERSORT, EPIC algorithm were utilized to calculate the proportion of immune-infiltrating cells in TME. IPS score and MANTIS Score were used to assess the immunotherapeutic value of Linc01436.
Results
The multivariate analysis showed that Linc01436 could predict lower pCR rate of paclitaxel-based NAC in breast cancer (OR = 0.25, P = 0.015, 95% CI: 0.077–0.725), especially in HR negative subtype (OR = 0.16, P = 0.022, 95% CI: 0.029–0.7). The Kaplan–Meier analysis suggested that high Linc01436 expression is associated with poor prognosis in both Renji cohort (HR = 4.58, P = 0.028, 95% CI: 1.51–14.5 ) and TCGA cohort (HR = 1.56, P = 0.033, 95% CI: 1.01–2.41 ). Then, the KEGG and GSEA analysis indicated that Linc01436 was mainly involved in immune related pathways. Further, bioinformatic analysis about the correlation between Linc01436 expression and tumor microenvironment indicated that Linc01436 expression was inversely related to CD8 + T cell infiltration and positively associated with PD-L1 expression and immunotherapy score.
Conclusions
Our findings indicated that Linc01436 may be a potential inverse predictor for pCR and DFS in breast cancer after NAC, especially for HR negative subgroup. Further, we also shed a broad insight into the molecular signal pathways involved in breast cancer progression and offered an opportunity to optimize the treatment of breast cancer.
Exploring different methods of Exaiptasia pallida infection to follow Vibrio parahaemolyticus dissemination in the whole animal
Authors: Billaud Mélanie , Czerucka Dorota
Published: February 2024

When studying host-pathogen interactions, the method of administration of the pathogen is a crucial parameter to control the injected dose of bacteria and the stress experienced by the animal during manipulation. Here we developed two models of infection (balneation or injection) of Exaiptasia pallida (E. pallida) by Vibrio parahaemolyticus expressing GFP (Vp-GFP). The injection, which provided better control of the bacteria quantity introduced inside the animal, induced a stress response with contraction and rejection of bacteria. We followed Vp-GFP dissemination by confocal microscopy over time at 6, 24 and 30 hours. During the early time of infection, bacteria adhering to the ectoderm were observed in both infection methods. At the latter time of infection Vp-GFP disappeared from ectoderm and appeared in the gastroderm. In case of injection, Vp-GFP were located in the gastroderm after 6 hours, whereas in the balneation case, bacteria reached the gastroderm until 24 hours. In both methods, bacteria disappeared from the ectoderm after 6 hours. In conclusion, by using Vp-GFP, we demonstrated for the first time that we can infect E. pallida and quantified the bacteria in whole animals. We also localized them in the different tissues, especially in mesenterial filaments, which are the main entry route of bacteria independently of the infection method.
The types of images to use in advertising for more emotional activation. A study using neuromarketing
Authors: González-Morales Antonio
Published: February 2024

This article evaluates, using neuromarketing, the arousal of various types of images that could be used in static marketing communication. An experiment was conducted in which 20 images were shown. The galvanic response of the skin, heart rate, and temperature were recorded. The study measured the activations generated by each type of image using the psychophysiological variable that best correlated with arousal, namely temperature. Images of type 1, such as smiling children, butterflies, flowers, and landscapes, were the most relaxing, while images of type 2, such as erotic images and parachuting, generated the highest level of arousal. The second level of arousal is generated by type 3, which are those depicting bodies that have been attacked, buried, disfigured, or shot. The third level of arousal generated is type 4, which are images of an individual who are imprisoned, drunk, beggars, or in a pool in very bad condition.
MANAGEMENT SLANT
● It is essential for marketing and advertising professionals to ensure that the level of emotional activation generated by communication pieces is adequate.
● There are some neuromarketing researches evaluating the arousal of images in advertising, but no one has verified the correlation level between the psychophysiological variable used and the emotional activations. Best psychophysiological variable for measuring the emotional arousal of static advertising through neuromarketing is the temperature, at least better than GSR and HR.
● Type of images that generates the most excitement measured with neuromarketing are the erotic images and extreme sport (parachuting). With the traditional method were the images of shooting, dead and disfigured and bloody people.
Conformational Investigations on Three Large Dinuclear Triple Helicates by Single Crystal X-ray Diffraction
Authors: Howard-Smith Kyle , Wallis Matthew , Flood James , Min Hyunsung , Tadros Joseph , Tian Ruoming , Bhadbhade Mohan , Marjo Chrisopher , Li Feng
Published: February 2024

Three new dinuclear triple helicates were synthesised using a ditpoic semi-rigid pyridylylimine ligand L, separated by a diphenoxy-biphenol spacer providing considerable length to the backbone. L and the new large dinuclear triple helicate complexes [Fe2L3](BF4)4 (1), [Ni2L3](BF4)4 (2) and [Zn2L3](BF4)4 (3) have been characterised in solution and solid state. Single crystal X-ray diffraction was used to investigate overall complex ion shape as the coordination sphere was modulated by metal ion selection. Small differences in complex shape were seen to arise due to subtle distortions in coordination sphere environments. This study sheds light on how the length and twist of dinuclear triple helicates can be tuned by selection of coordinating metal ion.
Charitable Activities and ‘Wellbeing’ in Indigenous Communities
Authors: Devlin Rose Anne , Planatscher Michela
Published: February 2024

Although charities are created expressly to benefit communities, it has proven difficult to capture the extent to which this mission is fulfilled. We tackle this challenge by focusing on charitable services provided to First Nations’ reserves and Inuit communities. Benefits are captured by their impact on a uniformly measured ‘community wellbeing’ (CWB) index, and on a comparable ‘individual wellbeing’ (IWB) index. Geo-coding technology enables the matching of the location of charities, Indigenous communities, and their residents. OLS estimations reveal robustly positive associations between the charitable sector and the CWB and IWB indicators; a Propensity Score Matching approach suggests that the presence of at least one charity is associated with about a 5-point or 7.5% increase in the CWB index. Nuanced evidence of causation is provided by an event-study exercise and the inclusion of community fixed effects. Several robustness tests corroborate the positive association between charities on CWB.
JEL codes: H00, I31, J15, D64, H49
Shear Behaviour of Waste Plastic Fibrous Concrete Beams Reinforced by New Configuration Fibre Reinforced Polymer Bars
Authors: Mahmoud Akram , Allawi Ali H. , AL-Hadithi Abdulkader I.
Published: February 2024

This paper presents an experimental study on the effect of the waste plastic and the fibre-reinforced polymer on the shear behaviour of the rectangular reinforced concrete beams. The experimental program was aimed to study the ductility of the beam that replaced the steel stirrups with the laminate of carbon fibre reinforced polymer as a transverse while the glass fibre reinforced polymer GFRP as longitudinal reinforced and add the waste plastic polyethylene terephthalate PET with different percentage 0.5%, 1%, and 1.5%. The parameters of this investigated include the percentage of waste plastic polyethylene terephthalate PET and the percentage of CFRP that replaced with steel which equals 50%, 100%, and 150% from the steel strips. All beams cast with the dimensions 150mm width, 200mm height, and 1400mm length to test under two-point load. The results of this paper showed that the clear effect of the polyethylene terephthalate PET on the shear behaviour of beams which enhanced the ductility, ultimate deflection, ultimate load, and stiffness. Besides to the results above the fibre reinforced concrete beam considered more safety against the corrosion because the fibre had a good corrosion resistance and also reduced the pollution in environmental due to the large amount of waste plastic bottles that produce each year
WITHDRAWN: ChatGptTweets Analyses Based On AI
Authors: Author Aya M. Al-Zoghby , Author Ahmed Ismail Ebada , Author Nora Yehia , Author Esraa Mohamed Al-Awadly , Author Ahmad Moawad
Published: February 2024

Sentiment analysis plays a crucial role in understanding public opinions and attitudes. In this study, we address the sentiment analysis of ChatGPT tweets, leveraging a diverse set of machine learning models. The dataset comprises user-generated tweets directed at ChatGPT, reflecting a spectrum of sentiments ranging from positive endorsements to negative critiques. Sentiment analysis is the process of utilizing text analysis tools to extract and classify sentiments conveyed in text data. As demonstrated by past research, sentiment analysis of conversational agent interactions, such as those with ChatGPT, has a great deal of potential to offer insightful information to help developers and users understand the perception and effectiveness of these agents. This understanding contributes to improving user experience and refining the capabilities of conversational agents like ChatGPT. For sentiment analysis in this context, the current systems either use a learning-based method or a lexicon-based approach. While lexicon-based techniques tend to be domain-specific, limiting their wide application, learning-based techniques require annotated data. In order to get better results, this research adopts a hybrid method that combines lexicon-based and learning-based strategies. General-purpose lexicons of sentiment are used, and the tweets are annotated using tools such as Text Blob. Moreover, term frequency-inverse document frequency (TF-IDF), a feature engineering technique, has been included to extract important features. Ultimately, the sentiments of the tweets are classified using a variety of learning models, such as Machine Learning with logistic regression (LR), random forest (RF), decision tree (DT), gradient boosting (GB), and multilayer perceptron (MLP). The suggested hybrid approach's effectiveness is assessed using the F1-score, accuracy, precision, and recall metrics. According to experimental findings, combining lexicon-based and learning-based strategies yields better outcomes than each one used alone. Additionally, Text Blob has demonstrated encouraging results, with 99 percent accuracy achieved with MLP.
On-chip programmable optical routing using nonvolatile Sb2Se3 phase-change metasurfaces
Authors: Zarei Sanaz
Published: February 2024

Interferometer meshes are underpinning many new technologies for fully programmable optical circuits; however, their large footprint restricts their scalability. Our investigations demonstrated a new approach for on-chip programmable optical routing based on integrated one-dimensional Sb2Se3 phase change metasurfaces on the silicon-on-insulator (SOI) platform. In the presented scheme, silicon functions as the light guide and Sb2Se3 provides the means for reconfigurability. Reconfiguration is achieved by the dynamic control over the refractive index of Sb2Se3 by selectively adjusting the crystalline phase of Sb2Se3. With a device footprint of 28µmx50μm, the proposed router is more compact than Mach-Zehnder interferometer meshes, while providing a foundry compatible, nonvolatile and broadband reconfigurable paradigm for programmable optical flow control.
Mycorrhizal diversity in Spiranthes spiralis (L.) Chevall
Authors: AKIN MUTLU Vildan , ÖZKOÇ İbrahim
Published: February 2024

For effective conservation of threatened orchids, identifying root-associated fungi and assessing their activity in seed germination is important for establishing conservation protocols. Therefore, our study investigated the diversity of Spiranthes spiralis‘s root-associated fungi. According to the culture-dependent approach, 37 endophytic fungi were isolated from the roots and morphologically and molecularly identified. It was determined that the dominant fungal species in the roots was the genus Tulasnella. For the first time in Türkiye, the Thanatephorus fusisporus species was isolated from roots. The germination efficiency of the isolated fungi in the symbiotic culture of S. spiranthes seeds was evaluated. VY 25 (Tulasnella) isolate isolated in April showed the highest germination rate (73.77%). VY 4, VY 18, VY 25, (Tulasnella) isolates promoted germination and seedling development. Thanatephorus (46.79%) and Ceratobasidium (32.42%) were not effective in germinating seeds. The study revealed that the fungal partner varied according to developmental stages and months. This study contains the first molecular data for organisms isolated from roots in Türkiye. According to these results, fungi that promote seed germination and plant growth can be recommended for the conservation and reintroduction of endangered temperate orchids.
“The Egyptian Hermes”: Philosophical Mysticism and Revealed Knowledge
Authors:   Immanuel Kant Baltic Federal University, Afonasin Eugene V.
Published: February 2024

The tendency to historicity is an important tendency in the modern history of philosophy. Hence a question: to which extend the treatises of Hermetic corpus seem to us historical, and properly connected with Egypt? Is it possible, taking into account the universal and mystical character of these texts, nevertheless to identify in them some elements, which would allow us to understand Hermeticism in the context of Hellenistic Egypt proper, and not broadly defined Hellenism? Does the traditional division of Hermeticism into “high” philosophical and “low” practical make sense in this context, or does this division represent another prejudice, which is better abandoned for a better understanding of the phenomenon under study? This article presents several positions on this subject matter developed over the past century, and offers certain observations that we believe allow us to better understand Hermeticism in the context of Alexandrian religious philosophy. For this purpose we examine in detail the origins of the legend of Thoth, which in the Greek context goes back to Plato, and then turn to an important hermetic text, the Definitions, which has survived only in its medieval translation into Armenian, and only partially preserved in the Greek. Indeed, only the aphoristic form of precepts allows the student to stop being distracted by the lectures of his celestial preceptor and begin to reflect independently on the universal truths expressed in the brief maxims. If this hypothesis is true, then the various Gnostic elements in hermetic treatises, often inappropriate, will appear as later additions by commentators to texts already in circulation in Hellenistic Egypt even before Gnosticism arose.
Trust of online consumers: Comparative estimation and the model of formation (on the example of Russia and China)
Authors:   Far Eastern Federal University, Tyurina Elena A. , Cao ZiYing ,   Far Eastern Federal University
Published: February 2024

Goal: the article presents the results of an empirical study modeling online consumer trust in various country contexts, considering the type of online shopping experience. Methodology: the research methodology is built on a comparative estimation of the e-trust in Russia and China based on the online survey data, the total sample was 1,800 respondents. Findings: a positive relationship of “precursor” factors (mechanisms for reviews, return/exchange of goods, online guarantees) with the trust of online consumers was proved; the significance of cross-country differences in the formation of online consumer trust in terms of the relevance and relevance of information contained in reviews, and the fairness of the return (exchange) process (using the samples of Russia and China as an example), and, conversely, cross-country differences have not been established in terms of accuracy and complexity information contained in reviews, the controllability of the return/exchange process, and the mechanism for online guarantee; confirmed the lack of relationship between the type of consumer experience and e-trust. Originality and contribution of the authors: the results of the study contribute to understanding the management of interactions between a company and online consumers and provide a basis for investment in the creation and development of cross-border e-commerce related to the formation of online consumer trust.
Telemedicine Practice: Current Challenges of Consent and Autonomy, Patient Privacy and Data Security Worldwide
Authors: Ahmad Areesha , Mustafa Aqsa , Qureshi Ali Akram , Naseem Ansa , Rana Ali Raza , Akhtar Marina , Rasool Alishba , Sadat Umar , Afzal Saira
Published: February 2024

Background: Telemedicine, facilitating medical services remotely, introduces ethical concerns. Safeguarding patient data, ensuring informed consent, addressing access disparities, and managing biases in artificial intelligence-driven diagnoses are critical. Navigating these challenges ethically is essential for harnessing telemedicine benefits while upholding patient trust and welfare. Objective: To ascertain the primary obstacles affecting global telemedicine practice, including issues concerning patient confidentiality, privacy, autonomy, informed consent, and data security. Methodology: Conducted a systematic literature review, for which we searched two databases (Pubmed and Google Scholar) between January 2018 to December 2022. Broad terms such as ethical issues, legal issues, health care providers were used as keyword searches. The authors used a narrative approach according to PRISMA guidelines 2020 (Checklist). The authors did a qualitative synthesis of selected studies according to inclusion criteria. The inclusion criteria required articles that reported ethical and legal concerns associated with the use of telemedicine; the full texts articles were electronically available and published in English. Systematic reviews and papers in other languages are not a part of the study. Results: Results showed that most reported ethical and legal concerns were related to privacy and confidentiality, followed by informed consent, patient autonomy and data security. From the 16 papers reviewed, authors identified or discussed the following ethical concerns faced by healthcare professionals during the use of telemedicine: patient privacy was addressed in 75% (n = 12/16) studies, informed consent 56.25% (n = 9/16), patient autonomy 31.25% (n = 5/16), data security 25% (n = 4/16). Conclusions: In the dynamic landscape of telemedicine, healthcare providers and policy makers play pivotal roles in addressing its ethical and legal concerns. Collaborative efforts are essential to establish clear guidelines, secure patient data, ensure informed consent, and create adaptable regulations, fostering a responsible and effective telemedicine ecosystem.
Women, water and access: inscribing gender power in and through a place
Authors: Akpabio Emmanuel M. , Wilson Nsikan-Abasi Udofia , Umoh Enobong C. , Udofia Eti-ido S. , Udo Ifiok I. , Elijah Edidiong , Essien Ubong E. , Akpan Itoro David , Umo Ini-Mfon B. , Umoren Itoro B. , Afiko Sunday , Ema Eti-Obong
Published: February 2024

This paper explores the socio-cultural and gender-based dynamics associated with place values, and their implications for women's access to water through case studies of upland and riverine communities in southern Nigeria. We used a range of fieldwork methods including public meetings, focus group discussions, in-depth interviews, keen observations, key informants and other secondary sources. Our findings show that drinking water sources are a part of the many forms of visible material structures that embody and generate automatic reproduction of gender-based beliefs, attitudes, feelings and practices. The outcome of such practices affects men and women differently in relation to access, workload and capacity for hygiene and other socio-economic practices. In discussing access to essential public goods, social and economic capacities take priority focus over the impact of ‘place values’ either as standalone or intersectional elements. Research should be expanded to incorporate these elements and their intersectional perspectives in shaping access to water.