bluuebunny/crossref_metadata_2025 huggingface dataset:
Grafts in Peyronie’s surgery without the use of prostheses: a systematic review and meta-analysis
Authors: Natsos Anastasios , Tatanis Vasileios , Kontogiannis Stavros , Waisbrod Sharon , Gkeka Kristiana , Obaidad Mohamed , Peteinaris Angelis , Pagonis Konstantinos , Papadopoulos Costas , Kallidonis Panagiotis , Liatsikos Evangelos , Drettas Petros
Published: January 2024

Peyronie’s disease (PD) is characterized by abnormal penile curvature, and various surgical methods have been developed using different graft materials. However, there is currently no universal agreement on which type of graft is the best. The objective of this review was to evaluate the available literature and identify the most effective graft material for penile curvature correction in PD. A literature search was conducted using electronic databases, including PubMed, Scopus, and the Cochrane Library. The patients, intervention, comparison, and outcome (PICO) approach was used to define the eligibility of studies. Two authors independently selected studies, evaluated them, and extracted data. Random-effect models using the DerSimonian–Laird method were used. Most studies were single-arm studies and had a high risk of bias. Buccal mucosa grafts (BMG) were found to result in the highest penile straightening rates and were associated with the least de novo erectile dysfunction. TachoSil grafts demonstrated a high success rate in straightening despite a higher mean preoperative curvature, while Tutoplast grafts had a higher incidence of postoperative erectile dysfunction. BMG had the highest percentage of postoperative penile straightening. Overall, the TachoSil graft showed the best performance when preoperative curvature is taken into account. Based on the available literature, BMG appear to be the most effective for penile curvature correction in PD, but this is offset by the requirement for low preoperative curvature. The TachoSil graft shows the best overall performance when preoperative curvature is considered. Comparative randomized clinical trials are still needed to determine graft superiority.
Association between Transcription Factor 7-Like 2 Gene Polymorphisms rs7903146 and rs12255372 with the Risk of Diabetic Nephropathy among South Indian Population
Authors: Ramanathan Balaji , Velayutham Kumaravel
Published: January 2024

Introduction:

Transcription factor 7-like 2 (TCF7L2) gene has been associated with the genetic predisposition of type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) in different populations. The study aimed to explore the correlation between rs7903146 and rs12255372 polymorphisms of TCF7L2 gene and DN among the South Indian population.

Methods:

Polymerase chain reaction (PCR)-based direct sequencing method and allele-specific PCR were used to determine the genotypes of TCF7L2 polymorphisms in 20 normal glucose tolerance (NGT) participants, 35 T2DM patients without DN and 35 T2DM patients with DN. The differences in genotype and allelic distribution between the study groups were analyzed by Chi-square test and odds ratio (OR) with 95% confidence interval (CI) which were used to indicate the relative risk of DN.

Results:

The distribution of TCF7L2 gene polymorphism rs7903146 prevalence was as follows: in the NGT group, CC, 65%; CT, 30%; TT, 5%; in the T2DM without DN group, CC, 25.71%; CT, 62.86%; TT, 11.43%; and in the T2DM with DN group, CC, 31.43%; CT, 60.0%; TT, 8.57%. The distribution of rs12255372 was as follows: in the NGT group, GG, 80%; GT, 15%; TT, 5%; in the T2DM without DN group, GG, 42.86%; GT, 41.46%; TT, 8.57%; and in the T2DM with DN group, GG, 48.57%; GT, 40%; TT, 5.71%. The T allele of rs7903146 polymorphism was associated with an increased risk of T2DM without DN (OR = 3.0; 95% CI = 1.21–7.437; P = 0.010) and T2DM with DN (OR = 2.51; 95% CI = 1.00–6.252; P = 0.04), and the T allele of rs12255372 polymorphism was also associated with increased risk of T2DM without DN (OR = 3.42; 95% CI = 1.18–9.902; P = 0.018) and not with T2DM with DN when compared with NGT individuals.

Conclusion:

In our study, the T allele of the rs7903146 single-nucleotide polymorphism in the TCF7L2 gene confers the risk of developing DN in diabetes patients, but the T allele of the rs12255372 polymorphism in the TCF7L2 gene is associated with T2DM and its association with DN is arbitrated through T2DM.
Evaluation of Acute Abdomen by Multidetector Computed Tomography: A Prospective Study in a Tertiary Care Hospital in Andhra Pradesh, India
Authors: Dileep K. , Kumar N. Uday , Kothareddy Lalithasree
Published: January 2024

Background and Objective:

Evidence on the efficiency of multidetector computed tomography (MDCT) in diagnosing acute abdomen in the Indian setting is lacking. This study was conducted to estimate the incidence of various causes of acute abdomen, correlate MDCT observations with postoperative findings, and estimate the sensitivity and specificity of MDCT findings.

Methods:

In this prospective study, 54 patients with acute abdomen were recruited in the emergency department (ED) of a tertiary care hospital in Chittoor, India. In these patients, MDCT observations were compared with postoperative findings, and the sensitivity and specificity of MDCT findings were estimated.

Results:

The majority of the patients presented with pain in epigastrium (n = 13, 24.1%), and 46 (85.2%) had nontraumatic acute abdomen. Pancreatitis was the major cause of nontraumatic acute abdomen. MDCT had failed to detect one case of acute appendicitis, one calculous cholecystitis, Meckel’s diverticulum, stricture ureter, and degloving injury of the colon. Overall, MDCT was positive for 57 out of a total of 63 conditions (eight patients had two different diagnoses) and it could rule out acute abdomen accurately in one patient. The sensitivity of MDCT in diagnosing acute abdomen was 92% and specificity was 100%.

Conclusion:

MDCT is a valuable diagnostic radiological investigation for patients with acute abdomen presenting to the EDs. Its multiple advantages put it ahead of the other traditional radiological investigations.
Role of Self-Directed Learning in Pedagogy – Current Scenario of Competency-Based Medical Education
Authors: Ravichandran Mythry , Taywade Manish , Pal Debkumar
Published: January 2024

Self-directed learning (SDL) is a learning procedure among participants where they understand their learning goals, formulate them, and identify resources for learning. There are four key steps of SDL. SDL allows learners to be more effective learners and social beings through peer group discussions. Hence, it helps develop innovative ideas and valuable insights. The COVID-19 pandemic has caused a significant paradigm shift in teaching–learning methods. The self-paced online courses are appeared to be a crucial part in learning during the pandemic. Those courses are somehow interlinked with the principles of SDL, thus SDL can be a boon in the current scenario with the COVID-19 pandemic. However, lack of independence and self-motivation forms a major barrier to SDL learning. The lack of a healthy relationship between the teachers/instructors and students and adequate technology might also affect the adoption of SDL. SDL will attain a massive success with the availability of adequate resources and technology and their effective utilization.
Frequency of Systemic Diseases and Oral Lesions Among the Institutionalized Elderly Subjects in the Northeast of Iran
Authors: Dalirsani Zohreh , Ghazi Ala , Firouzabadi Mohammad Ghanbari
Published: January 2024

Background:

With ageing, the number of systemic diseases and the consumption of drugs increase. Moreover, some oral lesions, especially denture-related lesions, are commonly observed.

Aim and Objective:

The purpose of this study was to determine the frequency of systemic diseases and oral lesions in the elderly in the Mashhad Geriatric Institutes.

Methods:

Institutionalized elderly people, who could cooperate for oral examination, enrolled in this descriptive cross-sectional study. The frequency of oral lesions and their systemic diseases were recorded in the self-made checklist. For statistical analysis, Student’s t-test and Chi-square test were utilized. The significance level was considered to be 0.05.

Results:

During the study, 224 elderly subjects with a mean age of 75.63 ± 11.22 years were evaluated. The mean duration of residency in the elderly nursing centres was 1.87 ± 1.37 years. Hypertension, Alzheimer’s disease and diabetes were the most common systemic diseases, and about 47% of the patients had two or multiple concurrent diseases. Among participants, 97.1% had at least one oral lesion. The most common oral lesions were fissured tongue (75%), sublingual varicosity (68.3%) and hairy or coated tongue (38.4%), respectively, which are classified as normal variations of oral mucosa. The most common pathological lesions were denture stomatitis, frictional keratosis and lichenoid reactions.

Conclusion:

Regarding to the high frequency of oral lesions among ageing people, regular examination of the oral mucosa for early detection of oral lesions and appropriate treatments is recommended.
Proposal for a Severity Score (DeASI, Dermatophytosis Area and Severity Index) for the Evaluation of Dermatophyte Infections – A Delphi Consensus Study
Authors: Kaliyadan Feroze , Das Anupam , Ashique Karalikkattil T. , Jayasree Puravoor , Panda Maitreyee , Panda Saumya , Chatterjee Manas , Dhafiri Mahdi Al , Harrison Preethy , Sasidharanpillai Sarita , Samad K. Abdul , Jagadeesan Soumya , Panicker Vinitha V. , Kumar K. Ajith , Kumar Piyush , Jakhar Deepak , Samuel Soumya , Rajalakshmi V. P.
Published: January 2024

Background:

There has been a significant increase in the incidence of recurrent, resistant, and extensive dermatophyte infections worldwide recently. This menace has spurred the need for more well-designed randomized controlled trials to optimize the treatment of dermatophyte skin infections. One of the limitations in designing such studies is the limited availability of standard and validated score, to measure the severity of dermatophyte infections.

Aims:

To create a severity score for the evaluation of dermatophyte infections.

Materials and Methods:

A Delphi consensus model was used to frame a severity scoring tool for superficial dermatophyte skin infections. Fourteen experts participated in the first round and twelve experts participated in the second round.

Results:

Based on the expert consensus, a final scoring system proposed was: Final Severity Score (FSS) = Sum total of Body Surface Area (BSA) in hand units for each patch multiplied by the sum of the scores for pruritis (P), lichenification (L), and actively raised borders (A) for each patch (FSS = BSA in hand units × (P + E + L + A) of patch 1 + BSA in hand units × (P + E + A) of patch 2 …etc.). For measuring hand units more accurately fractional values of 0.25 can be used (0.25 corresponding to an approximate 1/4th of a hand unit). A score of +1 will be added in case of the following - 1) Close contact/family member affected, 2) History of at least one recurrence in the previous 6 months after a course of oral antifungals, 3) History of immunosuppression (on immunosuppressive medication or having underlying immunosuppressive disease). The scores will be valid only if the patient has not used any treatment topical or systemic, for at least 2 weeks before enrolment.

Conclusion:

The proposed Dermatophytosis Area and Severity Index (DeASI) score will help the physicians and researchers standardize the treatment protocol for dermatophytosis, henceforth, assessing the response to therapy. This will also help to standardize the parameters of effectiveness while designing any clinical trial.
Clinico-Epidemiological Trends of Leprosy at a Tertiary Care Centre of South Rajasthan: A 10-Year Retrospective Study
Authors: Masatkar Vaishali , Meena Manju , Makhija Rini , Agarwal Chesta , Balai Manisha
Published: January 2024

Background:

Leprosy is a major public health problem in India, which affects many people every year and has significantly high new case detection rates in certain districts and blocks. According to the National Leprosy Elimination Program (NLEP) report of March 2019, there were a total of 1.14 lakhs new cases of leprosy in India with an Annual New Case Detection Rate (ANCDR) of 8.1 per 100,000 population.

Aim:

The present study aimed at determining the epidemiological and clinical profile of leprosy patients from a tertiary level teaching hospital in South Rajasthan.

Materials and Methods:

A retrospective, record-based study was carried out on patients registered in the leprosy clinic of a tertiary level teaching hospital of South Rajasthan during a period of ten years (2010-2019). Data regarding the demographic profile, clinical features, treatment given, and complications were analysed.

Results:

A total of 1372 patients registered in the leprosy clinic during a period of 10 years were evaluated. There were 1007 (73.4%) males and 365 (26.6%) females with a male-female ratio of 2.76:1. The majority of patients 671 (48.9%) belonged to the middle age group (21-40 years). Multibacillary leprosy was the most common clinical type seen in 1109 patients (80.8%). Borderline leprosy was the most common morphological type, determined in 625 (45.6%) patients, of which BL (21.0%) was the most common group. 16.7% patients presented with leprosy reaction at the time of initial diagnosis. Type 1 reaction was seen in 91(6.6%) and type 2 reaction in 138 (10.1%) patients. Grade I disability was observed in 347 (25.3%) patients whereas grade II disability was seen in 456 (33.2%) patients. 54 patients (3.9%) had a definite history of contact in the family. 28 patients defaulted during the study period. Yearly trend of epidemiological and operational parameters was observed, and the parameters were compared with the national data.

Conclusion:

Persistent high proportion of multibacillary cases and grade 2 disability indicates that leprosy continues to be a significant health care problem despite statistical elimination. There is a clear need to strengthen early detection, treatment and regular follow-up of these cases in both high and low endemic settings.
Red Flat Papules on the Abdomen and Lower Limbs of an Old Woman
Authors: Xu Wenjing , Cao Peng , Zhang Litao
Published: January 2024

Psoriasis and porokeratosis are two common skin diseases. Nevertheless, the occurrence of comorbidity is rare. To the best of our knowledge, these kinds of clinical histopathologic features of comorbidity were rarely reported previously. Here, we describe a case of a 75-year-old patient who presented with diffused porokeratosis in association with psoriasis.
Efficacy and Safety of Methotrexate in Psoriasis Vulgaris Long-Term Treatment: A Real-World Observation Study
Authors: Wilsmann-Theis Dagmar , Funk Rhena , Mössner Rotraut , Bieber Thomas , Wenzel Jörg
Published: January 2024

Background:

Methotrexate (MTX) in the therapy of psoriasis vulgaris (PV) is a well and long-established treatment option.

Aims:

To assess the long-term experience of individual patients in the real world with regard to the efficacy and safety of MTX in PV therapy.

Patients and Methods:

In a retrospective study, MTX as a weekly used monotherapy in PV was examined. Clinical data including the Psoriasis Area Severity Index (PASI), prevalence of psoriatic-arthritis (PsA), Investigator Global Assessment (IGA), laboratory parameters, occurrence of adverse events (AEs), dosing of MTX and characteristics of patients treated for at least 24 months were collected.

Results:

A total of 55 patients with 247 patient-years under MTX therapy were included. The mean PASI reduction was 51.2% with a significant (P < 0.001) improvement in the skin condition in the first 6 months of treatment, remaining stable thereafter. The mean MTX dose increased from 11.8 ± 3.7 mg to 12.9 ± 3.8 mg in the first year of therapy, with a constant mean dose in the following years. In 247 patient-years, no serious AE was documented. Gastrointestinal side effects or fatigue were commonly detected. The liver parameter alanine aminotransferase/ glutamate-pyruvate transaminase (ALT/GPT) (baseline 35.8 ± 22.0 U/L) increased after 3 years of therapy (42.0 ± 22.4 U/L; P = 0.013) without clinical significance.

Conclusion:

In this patient collective, MTX in low doses was effective and safe in long-term therapy. The improved skin condition was steady and reached by an unvarying dose. New data showed a better efficacy of MTX in higher doses; however, additional data must be collected on the long-term efficacy and safety of MTX with a higher dose regime.
SARS-CoV-19 and Generalised Pustular Psoriasis: A Lethal Combination
Authors: Narang Tarun , Sharma Apoorva , Bhandari Adhyatm , Handa Sanjeev , Dogra Sunil
Published: January 2024

Generalised pustular psoriasis(GPP) is a rare, potentially life-threatening variant of psoriasis with acute onset, widely spread pustular lesions on an inflamed base associated with a systemic inflammatory state. In the setting of the current COVID-19 pandemic, flares in pustular psoriasis have been reported, however these flares leading to mortality in SARS-CoV-2 infected patients is hitherto unreported. We present two cases of GPP flare following SARS-CoV-2 infection with fatal outcome. A 20 year old male, known case of GPP since 5 years presented with an exacerbation of his existing disease for 2 months. He had received methotrexate, cyclosporine, acitretin, apremilast, infliximab and secukinumab in the past. He was admitted and started on inj. methotrexate (subcutaneous) and cap. acitretin. During admission, he developed COVID-19 associated severe acute respiratory distress syndrome(ARDS). Despite timely intervention with life-saving measures, the patient could not be saved. The second case was a 52-year-old female, a case of GPP on treatment for the last 10 years, being maintained on cap. acitretin and cyclosporine. She also developed ARDS due to COVID infection. Despite being on acitretin for GPP and the appropriate management of severe COVID infection, her condition worsened and she expired within one day of admission. Both of our patients were not vaccinated against COVID-19. Awareness of potential risk of mortality in patients of GPP getting co-infected by COVID-19 is thus essential for dermatologists.
Designing and validating a research questionnaire - Part 2
Authors: Ranganathan Priya , Caduff Carlo , Frampton Christopher M. A.
Published: January 2024

Validity and reliability refer to the accuracy and consistency of a research tool. In the previous article in this series, we examined the development of a research questionnaire. In this article, we discuss the methods of determining the validity and reliability of a research questionnaire.
Effects of therapeutic patient education program on glycemic control and quality of life among children and adolescents with type 1 diabetes mellitus in Fez city, Morocco
Authors: Ait-Taleb Lahsen Hanaâ , Ragala Mohammed El Amine , El Abed Hanane , Zarrouq Btissame , Halim Karima
Published: January 2024

Context:

Type 1 diabetes mellitus (T1DM) is a chronic disease, mainly observed in children or youth, with a significantly increased incidence in young children. Structured therapeutic patient education (TPE) is a must to help them manage their disease effectively and lead a healthy lifestyle.

Aims:

This study aimed to assess the effects of a structured TPE program on glycemic markers and quality of life (QOL) of T1DM children and adolescents in Fez city, Morocco.

Settings and Design:

It is a quasi-experimental study.

Materials and Methods:

One hundred T1DM children and adolescents, aged 8–18, participated in a TPE intervention at the pediatric department in a hospital center in Fez, Morocco. Glycemic markers were measured and QOL was assessed by a validated questionnaire.

Statistical Analysis Used:

Parametric and nonparametric tests were used and statistical significance determined by P < 0.05.

Results:

At 3 months’ follow-up, both global and dimensional QOL mean scores improved significantly (P ≤ 0.0001), whereas glycosylated hemoglobin (HbA1c) decreased (10.28% vs. 10.62%), tough with no statistical significance (P = 0.160). Furthermore, a significant improvement was observed in the maximum preprandial (2, 11 g/L [1.51–2.58] vs. 2, 37 g/L [1.81–3.21], P = 0.001) and postprandial blood glucose levels (2, 50 g/L [1.90–3.27] vs. 2, 95 g/L [2.07–3.99], P = 0.001) after 3 months; with no significant change in their minimum.

Conclusion:

Although this TPE intervention was more effective in improving patients’ QOL than their HbA1c, it is worth striving to implement regular TPE programs for T1DM pediatric patients and adjust them to achieve a better patients’ glycemic markers levels.
Clinical practice recommendations for the use of next-generation sequencing in patients with solid cancer: a joint report from KSMO and KSP
Authors: Kim Miso , Shim Hyo Sup , Kim Sheehyun , Lee In Hee , Kim Jihun , Yoon Shinkyo , Kim Hyung-Don , Park Inkeun , Jeong Jae Ho , Yoo Changhoon , Cheon Jaekyung , Kim In-Ho , Lee Jieun , Hong Sook Hee , Park Sehhoon , Jung Hyun Ae , Kim Jin Won , Kim Han Jo , Cha Yongjun , Lim Sun Min , Kim Han Sang , Lee Choong-Kun , Kim Jee Hung , Chun Sang Hoon , Yun Jina , Park So Yeon , Lee Hye Seung , Cho Yong Mee , Nam Soo Jeong , Na Kiyong , Yoon Sun Och , Lee Ahwon , Jang Kee-Taek , Yun Hongseok , Lee Sungyoung , Kim Jee Hyun , Kim Wan-Seop
Published: January 2024

In recent years, next-generation sequencing (NGS)–based genetic testing has become crucial in cancer care. While its primary objective is to identify actionable genetic alterations to guide treatment decisions, its scope has broadened to encompass aiding in pathological diagnosis and exploring resistance mechanisms. With the ongoing expansion in NGS application and reliance, a compelling necessity arises for expert consensus on its application in solid cancers. To address this demand, the forthcoming recommendations not only provide pragmatic guidance for the clinical use of NGS but also systematically classify actionable genes based on specific cancer types. Additionally, these recommendations will incorporate expert perspectives on crucial biomarkers, ensuring informed decisions regarding circulating tumor DNA panel testing.
How to determine a curve singularity
Authors: Elias J.
Published: January 2024

We characterize the finite codimension sub-
${\mathbf {k}}$
-algebras of
${\mathbf {k}}[\![t]\!]$
as the solutions of a computable finite family of higher differential operators. For this end, we establish a duality between such a sub-algebras and the finite codimension
${\mathbf {k}}$
-vector spaces of
${\mathbf {k}}[u]$
, this ring acts on
${\mathbf {k}}[\![t]\!]$
by differentiation.
Многомерная задача Зарембы для уравнения $p( \cdot )$-Лапласа. Оценка Боярского-Мейерса
Authors: Alkhutov Yuriy Alexandrovich , Chechkin Gregory Aleksandrovich
Published: January 2024

Доказана повышенная суммируемость градиента решений задачи Зарембы в ограниченной строго липшицевой области для неоднородного уравнения $p( \cdot )$-Лапласа с переменным показателем $p$, обладающим логарифмическим модулем непрерывности.
Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report
Authors: Gramaça João , Fernandes Isabel Gomes , Trabulo Carolina , Gonçalves Joana , dos Santos Rita Gameiro , Baptista Adriano , Pina Idília
Published: January 2024

BACKGROUND

In patients with metastatic colorectal cancer (mCRC), the treatment options are limited and have been proved to be affected by rat sarcoma virus (RAS) mutational status. In RAS wild-type (wt) patients, the combination of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies with chemotherapy (CT) is more effective than CT alone. On the other hand, RAS-mutated patients are not eligible for treatment with anti-EGFR antibodies.

CASE SUMMARY

Eleven patients with initially RAS-mutated mCRC were followed from diagnosis to May 2022. At the time of cell-free DNA determination, five patients had undergone one CT line, five patients had undergone two CT lines, and one patient had undergone three CT lines (all in combination with bevacizumab). At the second and third treatment lines [second line (2L), third line (3L)], patients with neo-RAS wt received a combination of CT and cetuximab. In neo-RAS wt patients treated with anti-EGFR, our findings indicated an increase in progression-free survival for both 2L and 3L (14.5 mo, P = 0.119 and 3.9 mo, P = 0.882, respectively). Regarding 2L overall survival, we registered a slight increase in neo-RAS wt patients treated with anti-EGFR (33.6 mo vs 32.4 mo, P = 0.385). At data cut-off, two patients were still alive: A RAS-mutated patient undergoing 3L treatment and a neo-RAS wt patient who received 2L treatment with anti-EGFR (ongoing).

CONCLUSION

Our case series demonstrated that monitoring RAS mutations in mCRC by liquid biopsy may provide an additional treatment line for neo-RAS wt patients.
Comunicare interpersonală. Dinamica relației profesor-student post pandemie
Authors:   University of Arts Târgu Mureş, Olar Cristina Maria
Published: January 2024

The research is based on an analysis of the dynamics of the post-pandemic teacher-student relationship and the impact that online courses have had on the emotional, psychological and physical levels. This study is a personal analysis from the perspective of the teacher, on the type of relationship with students and the changes that have occurred in teaching, and communication with them. The experience of teaching online has caused changes in everyone's behavior and attitude. Both teachers and students have encountered technological, educational and emotional difficulties.
Muzički diskurs u kosmološkom pristupu Crkvi Klimenta Aleksandrijskog
Authors:   University of Belgrade, Faculty of Orthodox Theology, Stevanović Sanja
Published: January 2024

The philosophical and theological basis of the musical allegories from the writings of Clement of Alexandria is unanimously confirmed by all previous research. One of the distinctive features of Clement’s theology is a specific ecclesiological model that directly shapes the understanding of the Eucharistic chant. The research problem of this paper is the appearance of musical discourse in the three writings of Clement of Alexandria. By situating the theological issues Clement raises through musical discourse in the works Protrepticus, Stromata, and Paedagogus, we will examine how Eucharistic chant and music relate to the understanding of the Church as a reality that was perfect in the beginning. The goal of the paper is to connect the cosmological approach of the Church with the theme of Eucharistic chant and music.
Pediatric palliative care and childhood neurosurgery: reflections based on a quantitative analysis of a survey data
Authors: Luiz Ferreira Esther Angélica , Sobrinho Valete Cristina Ortiz , Sarracini Maycon Rodrigo , Zanatta Ricardo Patrezi , Liberal Lucas Pereira , Gomez-Cantarino Maria Sagrario
Published: January 2024

INTRODUCTION: In recent years, the profile of pediatric patients has changed, with the need for assistance for children living with chronic and life-threatening diseases becoming increasingly frequent. In this scenario, Pediatric Palliative Care (PPC) emerges as an integral and respectful form of assistance for these patients and their families. Understanding that neurosurgery is an extremely important area within Pediatric Palliative Care, as there are many intersections between the two areas, this research aimed to reflect on how this interaction is being carried out in practice. MATERIAL AND METHODS: It is an observational, descriptive, cross-sectional study, of survey type, in which the study population was composed of a convenience sample, using the snowball strategy. Analyses were performed with the aid of the statistical program Stata version 13.0 (Stata Corp, L. C.). Results are presented as frequencies and 95% confidence intervals, graph, and table. RESULTS: The sample represented 90 PPC services, almost all of which have physicians (97.90%). Among the medical specialties, none of the services reported having a neurosurgeon on the team. DISCUSSION: Several themes required by the National Medical Residency Commission for the training of neurosurgeons cover Pediatric Palliative Care, such as pain, bioethics, communicating difficult news and others. Therefore, the real rapprochement of the two areas is extremely important to ensure comprehensive care for the patient. CONCLUSIONS: There are important gaps between Pediatric Palliative Care and Pediatric Neurosurgery, reinforcing the importance of including the topic for neurosurgery residents and continuing education for those already trained.
The role of pediatric neurosurgery in the Sustainable Development Goals
Authors: De Oliveira Ricardo , Ballestero Matheus
Published: January 2024

The Sustainable Development Goals (SDGs) are a set of 17 interconnected global goals adopted by all United Nations (UN) Member States in 2015 to end poverty, reduce inequality and build more peaceful, prosperous societies by 2030 [1] (Figure.1).

The SDGs aim to leave no one behind and promote peace, prosperity, and the protection of the planet [2].

         Pediatric neurosurgery intersects with several of these goals, contributing to the overall improvement of health, well-being, and social and economic development. Here are some ways in which pediatric neurosurgery aligns with the SDGs:
Análisis de la situación agrícola de la República Mexicana
Authors: Sánchez Gómez Carlos , Caamal Cauich Ignacio , Bautista Hernández Beatriz , López José César Constantino
Published: January 2024

El objetivo de la investigación fue efectuar un análisis de la situación agrícola de la República mexicana (1968-2018). Para el estudio se utilizó estadística descriptiva, teoría económica, los modelos de regresión y el índice de datos de “agricultura y desarrollo rural” del Banco Mundial. El PIB agrícola de México representa un poco más del 3% en la producción nacional, con 12.81 % de la población económicamente activa que se dedica a las actividades primarias, y 25 millones de personas que viven en el área rural en el año 2018. La superficie agrícola es de 1 068 910 km2, tierras cultivables de 239 250 km2, superficie forestal de 659 476 km2 y se producen cereales en una superficie de 94 260 km2. Hay una utilización promedio de 96 tractores/100 km2. El consumo promedio de fertilizante fue de 73 kg/ha y el 5 % de la superficie agrícola es de regadío. En el mediano plazo, el índice de cosecha, el rendimiento de los cereales, la producción de cereales, el índice de producción animal y el índice de producción de alimentos continuarán creciendo a través del tiempo. En el mediano y largo plazo continuará la disminución de las personas dedicadas a las actividades agrícolas y, en términos porcentuales, seguirá disminuyendo el valor agregado generado por la agricultura. En el corto plazo, se prevé se sigan presentando tasas negativas del crecimiento de la población rural.
The Impact of Climate Change on Grape Crops Development in Western Ukraine
Authors: Savina Olena , Hliudzyk-Shemota Marharyta , Sadovska Nadija , Popovych Halyna , Sheydyk Karolina , Vantiukh Olesia
Published: January 2024

Climate change is becoming more noticeable and affects agriculture, particularly grape growing, which determines the relevance of research. The aim is to analyse the impact of climate change on the development of grape crops, yield, and quality. To this end, the study was conducted in the temperate climate zone from 2010-2022 by phenological observations and chemical and organoleptic methods. The results indicate a delay in the phenological stages of grapes, particularly budding and earlier flowering, which can affect yield. Changes in the composition of berries have also been identified, including a decrease in vitamin C and anthocyanins and an increase in sugar content due to the increased temperature. Recommendations include the selection of climate-resistant varieties, the use of irrigation systems and moderate watering. The novelty of the research lies in understanding the impact of climate change on grapes in a particular region. It is of strategic importance for the adaptation of agriculture to new conditions. Further research could focus on using cooling and biological products to ensure optimal growing conditions for grapes and increase resilience to climate change.
Procesos y caracterización del manejo productivo de un grupo genético de gallinas criollas, Riobamba, Ecuador
Authors: Toalombo-Vargas Paula Alexandra , Andino-Nájera Pablo Rigoberto , Arboleda-Álvarez Luis Fernando , Santillán-Espinoza Diego Iván , Santillán-Lima Juan Carlos
Published: January 2024

Este artículo resulta de una investigación cuyo objetivo fue establecer el manejo productivo de un grupo genético de gallinas criollas en una zona de Riobamba, Ecuador. Para el proceso investigativo, la metodología aplicada implicó la evaluación de las características cuantitativas y cualitativas, en donde se utilizaron 42 aves criollas, 36 hembras y 6 machos. Se utilizó la estadística descriptiva, específicamente pruebas como las medias, desviación estándar, valores máximos y mínimos. El procedimiento también incluyó la toma de medidas zoométricas, indicadores fanerópticos además de la caracterización de los huevos criollos en cuanto a sus dimensiones, peso de clara, yema, cascaron y pigmentación de yema. En lo que respecta a los principales resultados registrados en las variables productivas se pueden señalar: peso inicial (1093±234.798) g, peso final (1231.50 ±214.82) g, ganancia de peso total (167.08 ±190.538) g, producción de huevos totales/ave/día (6.42 ±0.13) %, producción de huevos totales/ave alojada (6.16) %, peso promedio del huevo (23.32) g, y, peso del total de huevos producidos (3101). En general se concluye que el manejo productivo de las gallinas criollas dependería de factores en cuanto a edad, fisiología y el proceso de adaptación en el que se encuentren, además se determinó que la poca tecnificación aplicada en las producciones de aves criollas, provoca que se desperdicie en cierta manera, características importantes en esta especie como rusticidad, adaptación, reproducción, entre otros aspectos. Es así entonces que se considera importante proponer programas de producción con la finalidad de preservar esta población de aves, evitando así su posible desaparición.
Negative Factors Influencing the Policy of Public Administration Development of the Agriculture in the Region: The Exampleof Poland
Authors: Blyznyuk Andrii , Kiyanka Iryna , Ilkiv Oleh , Cherkaska Valeriy , Berezynskyi Leonid , Havrichkov Oleksandr
Published: January 2024

The main purpose of the article is to determine the level of importance and influence of the main negative factors influencing the formation of an effective policy for the development of agriculture in the region. And also, to formulate appropriate recommendations for overcoming or adapting modern agricultural development policies based on these factors. The set purpose is achieved through the use of a specific methodology, which includes the method of expert survey and analysis of hierarchies. As a result, seven key negative factors were identified that have the greatest negative impact on the formation of an effective policy for the development of agriculture in the Poland region. For a better understanding of the proposed methodology, we chose a separate region of Poland-Podkarpackie Voivodeship. Ultimately, the most appropriate recommendations were proposed to improve agricultural development policies for the region. The study has a limitation because it includes an analysis of region-specific negative factors. Given this, their level of influence and importance, as well as the prevailing recommendations, are highly specific to this region. In the future, it is planned to expand the analysis of factors and the formation of recommendations across the entire EU sector.
Estimación de pérdidas económicas en Cacao causado por Escoba de Bruja (Crinipellis Perniciosa) y Monilia (Monilia Roreri) en pequeños productores
Authors: Pino Peralta Sergio , Washburn Herrera Christian , Garabiza Castro Bella
Published: January 2024

Esta investigación se realizó en la “Asociación El Deseo” ubicada en el cantón Milagro de la provincia del Guayas, Ecuador; la misma que es parte de la Unión de Organizaciones Campesinas Cacaoteras (UNOCACE). El objetivo fue estimar el beneficio perdido en cacao arriba causado por las enfermedades Escoba de bruja (Crinipellis Perniciosa) y Monilia (Monilia Roreri) en el año 2022. Se utilizó el método mixto que integra un examen cuantitativo y cualitativo, el tipo investigación fue documental y descriptiva, ya que la recolección de datos se realizó de fuente primaria en la UNOCACAE. La asociación El Deseo tuvo un beneficio perdido total de USD 45.854,22. Se concluye que en el año 2022 cada productor perdió en promedio unos USD 1.042,14 por el ataque de la Escoba de bruja y Monilia, en las 44 familias de dicha asociación; es decir, la afectación fue del 35,9% de la producción total y de los ingresos en ese año.
Integrating Humanitarian Demining with Remote Control Tech in Educational Process
Authors: Dziuba Petro , Neroba Vadym , Chukanov Andrii , Shcherbliuk Volodymyr , Shkvarskiy Oleksandr
Published: January 2024

The aim of the work is to investigate the possibility of introducing the system of humanitarian demining into the educational process of higher education institutions (HEIs) of Ukraine. The introduction of modern equipment against improvised explosive devices explosive items, for example remotely controlled ones, was also studied. Methods used: content analysis, semi-structured interviews, and self-assessment of the sapper’s competence. The conducted research for the first to describe the results of the possibility of introducing a system of humanitarian demining in HEIs of Ukraine, where it has not yet been introduced. It was found that educational institutions for military training in various fields have sufficient material and technical resources for professional training of demining personnel. It is also proposed to renew or renovate the demining equipment, as well as introduce a project activity on the development of remotely controlled mechanisms against explosive items into the educational process. The results can be useful to researchers and teachers who are working on updating the content of education in accordance with the current security needs. Further research should be conducted on the monitoring of new demining equipment.
Estudio del comportamiento del viento en zonas Alto Andinas, Chimborazo - Ecuador
Authors: Mantilla-Cabrera Carmen Elena , Barba-Vera Ruth Genoveva , Morales-León Vanessa Belén , Inca-Falconí Alex Fabián
Published: January 2024

El objetivo de esta investigación es analizar, desde el punto de vista estadístico, el comportamiento estocástico del viento tanto en magnitud como dirección y diagnosticar la viabilidad técnica de los emplazamientos ubicados en zonas altas andinas ecuatoriales de la Provincia de Chimborazo, a alturas comprendidas entre 2900 msnm y 4300 msnm. El análisis se orientó hacia la descripción de las variaciones de la velocidad y de dirección de viento para los periodos 2015, 2016 y 2017, utilizando datos meteorológicos de las estaciones automáticas “Chingazo y Chimborazo”. En cuanto a los resultados, se obtuvo valores medios anuales de velocidad de 6,23 m/s y 10,74 m/s para cada emplazamiento respectivo, también se observó que el 74.11 % de las velocidades muestreadas de la estación meteorológica Chingazo fueron mayores a 3 m/s con un máximo de 20 m/s; y, en el emplazamiento Chimborazo, el porcentaje de velocidades mayor a 3 m/s fue de 88.85% con una velocidad máxima de 31 m/s. En el caso del emplazamiento Chimborazo, la dirección predominante del viento fue Este_Sur_Este (ESE) con un 35.33%; y, para el emplazamiento Chingazo, la dirección predominante fue Este_Norte_Este (ENE) con un 32.43%, con resultados significativamente mayores que los requerimientos exigidos para la factibilidad técnica de implementar parques eólicos. Como conclusión, se puede afirmar que el análisis estadístico realizado en los emplazamientos es considerados factibles para implementar parques eólicos en zonas altas andinas ecuatoriales de la Provincia de Chimborazo a altitudes entre los 2900 msnm y 4300 msnm.
Líneas de investigación para el impulso de la gestión de los residuos de aparatos eléctricos y electrónicos en Venezuela
Authors: Hernandez Quijada Vanessa Margarita , Pereira Ibarra Carlos Julio , Chiquito Martínez Yorlandis
Published: January 2024

En Venezuela existen políticas para la gestión de los desechos sólidos peligrosos, pero no están definidas las directrices para el caso de recuperación, tratamiento y disposición de los residuos de aparatos eléctricos y electrónicos. Por ello, estos residuos pueden representar un problema en la gestión ambiental. Una de las estrategias empleadas para promover la gestión de los residuos electrónicos es a través del impulso de líneas de investigación que contribuyan al aprovechamiento de los residuos y mejoras a los sistemas de gestión; por ello, la presente investigación tiene como objetivo analizar las potenciales líneas de investigación para la gestión de los residuos electrónicos que se pueden emplear con las capacidades nacionales. A partir de la elaboración de una matriz FODA, se proponen 11 líneas de investigación que se enfocan en el desarrollo de proyectos que promueve la generación de estadísticas, implementación de normativas y cumplimiento de los convenios internacionales. Con el análisis FODA también se observó que las fortalezas están asociadas al capital humano y a la experiencia en el tratamiento de los residuos electrónicos, y las debilidades están relacionadas con limitaciones del financiamiento e incertidumbre concerniente al marco legal.
Strategic Assessment of the Impact of Forestry on the Environment to Achieve Sustainable Development
Authors: Oshurkevych-Pankivska Oksana , Pankivskyi Yurii , Zadorozhnyy Andriy , Reznichenko Vita , Kolomiiets Liudmila
Published: January 2024

The relevance of the proposed topic is driven by global climate change and the urgent need to optimize the management of natural resources. Forests play a central role in the global carbon balance and are of great socio-economic importance for local communities. The research aims to analyze forest management strategies and their environmental impacts. The study focuses on forest ecosystems in different regions and climatic zones. The methodology is based on a comprehensive analysis of scientific literature, statistical data, and the examination of practical examples. The article highlights the dynamics of forest ecosystem restoration following different types of forestry interventions in different climatic zones, including the Ukrainian context. The impact of forest management on global carbon balances and the socio-economic sphere is assessed. The research shows that adaptive strategies can contribute to sustainable development and biodiversity conservation. The conclusions provide recommendations for the implementation of these strategies at the national level, especially in Ukraine.
Loci de caracteres cuantitativos y su asociación con la producción de huevos en gallinas cruzadas IPA x FAGRO
Authors: Arcia José Luis , Galíndez Rafael , De La Rosa Oscar , Angulo Luis , Márquez Alexis
Published: January 2024

Se extrajo sangre a 60 animales, con la finalidad de estimar la asociación entre los marcadores genéticos MCW007, ADL0253, MCW0241 y ADL0201, y la producción de huevos hasta las 40 semanas de edad (NH40), 41 a 60 (NH4160) y total (NH60), en una población F2, producto del cruce entre las razas de gallinas IPA y FAGRO. El ADN se purificó, amplificó y se realizó la electroforesis vertical en geles de poliacrilamida teñidos con nitrato de plata. El análisis de varianza evidenció que, ADL0201 está asociado a NH40 y NH60, con 13% y 0,08% de variación, respectivamente. Los h2 estimados por máxima verosimilitud restringida resultaron en NH40 = 0,12 y NH60 = 0,23. A pesar que el marcador ADL0201 está asociado a la producción de huevos, el progreso genético que pudiera obtenerse es muy bajo; esperando una mayor respuesta a la selección con el uso de los métodos tradicionales.
The use of Digital Technologies to Ensure Environmental Safety in the Context of the Green Economy Development
Authors: Arefiev Serhii , Zhyhlei Iryna , Pereguda Yuliia , Kryvokulska Nataliia , Lushchyk Mariya
Published: January 2024

The purpose of the article is to justify the use of digital technologies to ensure environmental safety in the context of the green economy development, taking into account its tasks and principles. The research methodology is a comprehensive approach that makes it possible to comprehensively approach the methods and techniques of scientific knowledge, to carry out a comprehensive analysis of the subject of research, to reveal the essence of the green economy and the purpose of implementing digital technologies to ensure environmental safety, to follow the system-forming connections between economic, social, and ecological processes in a global dimension, to highlight the directions of using digital technologies to ensure environmental safety, which gives a synergistic effect for the development of the green economy. It has been proven that the use of artificial intelligence technologies, information logistics systems make it possible to solve many problems in agriculture in the process of production, processing, transportation and preservation of agricultural products. Highlighting the negative consequences of digitization in relation to the environmental component, which includes the increase in energy consumption, electronic waste and cyber security, made it possible to outline directions for their leveling.
The Creative Development of Green Ecotourism Concept as a Sustainable Development Factor
Authors: Voronkova Valentyna , Nikitenko Vitalina , Oleksenko Roman , Cherep Alla , Cherep Oleksandr , Harbar Halina
Published: January 2024

The purpose of the research is the theoretical and practical aspects of the formation of the concept of green ecotourism as a digital developmental creative technology. The research methodology of green ecotourism concept as a sustainable development factor can be analyzed using the following methods: 1) Data science - analysis and processing of travel agency data in digital form; 2) Data Mining, which includes data extraction, intelligent data analysis, in-depth data analysis aimed at expanding and personalizing customer data for further touristic business development; 3) Big data methods; 4) Agile method for improving digital technologies; 6) Scrum methods for analyzing rural green ecotourism phenomenon. Researching result. 1.The historical prerequisites for the green ecotourism formation as a social and cultural phenomenon and dynamic process are analyzed. 2. The essence of the revitalization concept of rural areas with expanding opportunity aim of the culture and tourism industry has been clarified. 3. The directions of the ecotourism development as a sustainable development economic factor have been identified. 4. The ecosystem is revealed as a complete natural system for the ecotourism development.