bluuebunny/crossref_metadata_2025 huggingface dataset:
Hasta Karya Ekstrakurikuler Pramuka Untuk Meningkatkan Imun Santri Pondok Pesantren Pandemi Covid-19
Authors: Susanto Ratno , Nugrahani Ari , Afandi Achmad
Published: April 2022

Dua tahun sudah pandemi yang dilalui oleh masyarakat Indonesia, dimana pandemi ini selalu memusnahkan pendapatan ekonomi, pendidikan, serta kegiatan lainnya. Pesantren membuka kembali kegiatan belajar mengajar dan taklim. Selain karena materi pembelajaran yang perlu disampaikan kepada para santri, pun karena suasana dan kegiatan taklim di Pesantren yang sudah sangat dirindukan para santri yakni ekstrakurikuler pramuka. Ekstrakurikuler pramuka yang sudah libur selama 2 tahun, dimana Pembina dan peserta untuk pembelajaran selalu mengalami kendala. Permasalahan dipondok al rifa’I putri ialah kekurangan pembina pramuka, adanya sarana dan prasarana yang kurang dimanfaatkan oleh kakak pembina pramuka, pembelajaran pramuka yang kurang menarik, serta keterbatasan kemampuan siswa saat membuat hasta karya. Metode yang digunakan yakni pelatihan, dan pendampingan serta kualitatif. Hasil dari pengabdian masyarakat sangat efektif dalam pembelajaran hasta karya untuk meningkatkan imun di Covid- 19, serta menggali bakat dan minat siswa untuk mandiri, berwirausaha. Pengasuh pondok pesantren sangat antusias dalam kegiatan belajar hasta karya diekstrakurikuler pramuka demi kemajuan pendidikan bangsa.
EFEKTIFITAS UNDANG-UNDANG NO 11 TAHUN 2008 TENTANG INFORMASI DAN TRANSAKSI ELEKTRONIK SEBAGAI UPAYA PENANGGULANGAN TINDAK ASUSILA BERBASIS TEKNOLOGI (CYBERSEX)
Authors: Ilham Nur Muhamad , Jaya Febri
Published: April 2022

Abstract: Cybersex is an intimate activity carried out through electronic media. The nature of this Cybersex act itself is a non-violence crime where this crime causes the victim to be invisible or invisible, thereby reducing the fear of this crime. even though the consequences of cybersex itself are very large. In order to protect the victims and deter the perpetrators of this cybersex act, good laws and regulations are needed. In this case, Law No. 11 of 2008 concerning information and electronic transactions is the main regulation in mediating cybersex problems that are happening in society. However, whether legislation no. 11 of 2008 concerning information and electronic transactions has been efficient in tackling cybersex problems that occur in the community or is the regulation made only as a mere formality and has not been able to become a government effort in tackling cybersex actions. The purpose of this study was to examine the efficiency of Law No. 11 of 2008 concerning information and electronic transactions in dealing with cybersex problems. In this study, the researchers used a descriptive analytical method, which relates the current rules and relates to the problems that the researcher has described. This research examines the government's efforts, inhibiting factors and the application of sanctions as social control which is linked to Law No. 11 of 2008 concerning information and electronic transactions.Keywords: Efficient, Law, Cybersex.
ANALISIS FAKTOR-FAKTOR YANG MENDORONG KEBERHASILAN USAHA PADA USAHA OPTIK DI ERA PANDAMI DI KOTA PADANG
Authors: Novalinda Rina , Iman Suryanta Dolly
Published: April 2022

Abstract: Optical business is a business that supports health services that carry out the business of providing, storing and distributing optical devices. The optical business is an alternative business that has a fairly high prospect and is a business that continues to warm up. The purpose of this study was to determine the factors that influence the success of the Optics business in the city of Padang. The research method is correlational quantitative. The sample is 30 people. The data collection technique used a questionnaire with a Likert scale. Descriptive data analysis techniques, test requirements and hypothesis testing. The results of the study describe the data descriptively that the entrepreneurial knowledge of Padang City optical business actors is in the high category, entrepreneurial behavior is included in the good category and marketing strategies are in the good category. the success of the optical business of the city of Padang and the marketing strategy have an effect on the success of the optical business of the city of PadangKeywords: Entrepreneurial knowledge, marketing strategy behavior, business success.
UPAYA MENINGKATKAN HASIL BELAJAR TEMA PERSATUAN DALAM PERBEDAAN MENGGUNAKAN MODEL PEMBELAJARAN EXAMPLES NON EXAMPLES SISWA KELAS VI SD NEGERI 01 TANJUANG GADANG KECAMATAN LAREH SAGO HALABAN SEMESTER 1 TAHUN PELAJARAN 2019/2020
Authors: Yusniar Yusniar
Published: April 2022

Abstract: Based on the results of temporary observations, it can be seen in the teaching and learning process in the classroom the following things:1. Low student learning outcomes, 2. Lack of student activity in following the teaching and learning process, 3. There is no fun learning, 4. There is no creative learning. This study was conducted with the aim of describing Efforts to Improve Learning Outcomes with the Theme of Unity in Difference Using Learning Models Examples Non Examples for Class VI students of SD Negeri 01 Tanjuang Gadang, Lareh Sago Halaban District, Semester 1 of the 2019/2020 Academic Year. Classroom Action Research (CAR) is a form of reflective study by the perpetrators of the actions taken to improve the rational ability of the actions they take, as well as to improve the real conditions in which the practice of implementing the learning is carried out in the classroom. In this classroom action research (CAR), the research model developed by Kemmis and Taggart uses a spiral system cycle, each cycle consists of 4 components, namely: 1) planning; 2) action; 3) observation and 4) reflection. Student learning outcomes, the researchers held a test for each cycle. The results of the second cycle test were compared with the KKM that had been set at SD Negeri 01 Tanjuang Gadang, Lareh Sago Halaban District, Semester 1 of the 2019/2020 Academic Year, which was 75 for individual completeness. Based on the results of the test above, it can be seen that in the first cycle of 16/55% of students, 13 students or 45% completed, and in the second cycle 26/89 students who completed learning. This proves that student learning outcomes in the first cycle to the second cycle are 36%.Keywords: Learning Outcomes, Examples Non Examples.
Status of the Wild Goat Capra aegagrus Erxleben and Asiatic Mouflon Ovis gmelinii Blyth (Mammalia: Cetartiodactyla) Within Distribution of Persian Leopard Panthera pardus L. in Nakhchivan (Azerbaijan)
Authors: Veinberg P. , Fatullaev P. , Mamedov I. , Talybov T. , Askerov E.
Published: April 2022

Census of the bezoar goat Capra aegagrus and Asiatic mouflon Ovis gmelinii populations was carried out in July and December 2018 in the Leopard’s Panthera pardus range in south-eastern part of Nakhchivan (Azerbaijan). Dynamics of numbers, population densities and distribution for both species is positive since 2006. Study results indicate that effective protection significantly improved status of the bezoar goat and mouflon, even under circumstances of intensive livestock grazing in habitats of wild ungulates. Reproduction and juvenile survival rates for both species were significantly lower than in other parts of their range and lower than in the same areas in 2012–2013, but the factor that might have caused this was not established. Low indices of reproduction and juvenile survival can hardly be caused by high population densities, press of predators, leopard in particular, and bad weather, and their reasons remain unknown.
Considering the role of material gerontology in reimagining technology design for ageing populations
Authors: Manchester Helen , Jarke Juliane
Published: April 2022

The promise of technology to provide solutions to the global concern of ageing populations has largely been unfulfilled. We argue that this is, in part, related to design processes that fail to take account of the rich material lives of older people, and that often adopt stereotypical views of older people as frail, vulnerable and unskilled. We draw on empirical data from two co-design projects, to suggest the contributions that material gerontologists could make to design teams creating technologies for ageing populations. We suggest material gerontologists bring three key elements to interdisciplinary design teams: (1) making visible the intra-action of humans and non-humans in co-design processes; (2) reconfiguring co-design response-ably with older adults; and (3) reimagining possible outcomes of technology design. We believe that this approach can result in the design of products, services and innovations that respond better to the heteroge­neous needs and life-worlds of older adults.
Pediococcus acidilactici Strain Alleviates Gluten-Induced Food Allergy and Regulates Gut Microbiota in Mice
Authors: Fu Wenhui , Chen Chen , Xie Qiang , Gu Shimin , Tao Sha , Xue Wentong
Published: April 2022

Wheat flour, the most important source of food globally, is also one of the most common causative agents of food allergy. Wheat gluten protein, which accounts for 80% of the total wheat protein, is a major determinant of important wheat-related disorders. In this study, the effects of Pediococcus acidilactici XZ31 against gluten-induced allergy were investigated in a mouse model. The oral administration of P. acidilactici XZ31 attenuated clinical and intestinal allergic responses in allergic mice. Further results showed that P. acidilactici XZ31 regulated Th1/Th2 immune balance toward Th1 polarization, which subsequently induced a reduction in gluten-specific IgE production. We also found that P. acidilactici XZ31 modulated gut microbiota homeostasis by balancing the Firmicutes/Bacteroidetes ratio and increasing bacterial diversity and the abundance of butyrate-producing bacteria. Specifically, the abundance of Firmicutes and Erysipelotrichaceae is positively correlated with concentrations of gluten-specific IgE and may act as a fecal biomarker for diagnosis. The evidence for the role of P. acidilactici XZ31 in alleviating gluten-induced allergic responses sheds light on the application of P. acidilactici XZ31 in treating wheat allergy.
Salvia miltiorrhiza Bge. (Danshen) in the Treating Non-alcoholic Fatty Liver Disease Based on the Regulator of Metabolic Targets
Authors: Liu Jie , Shi Yun , Peng Daiyin , Wang Lei , Yu Nianjun , Wang Guokai , Chen Weidong
Published: April 2022

Non-alcoholic fatty liver disease (NAFLD) is rapidly prevalent due to its strong association with increased metabolic syndrome such as cardio- and cerebrovascular disorders and diabetes. Few drugs can meet the growing disease burden of NAFLD. Salvia miltiorrhiza Bge. (Danshen) have been used for over 2,000 years in clinical trials to treat NAFLD and metabolic syndrome disease without clarified defined mechanisms. Metabolic targets restored metabolic homeostasis in patients with NAFLD and improved steatosis by reducing the delivery of metabolic substrates to liver as a promising way. Here we systematic review evidence showing that Danshen against NAFLD through diverse and crossing mechanisms based on metabolic targets. A synopsis of the phytochemistry and pharmacokinetic of Danshen and the mechanisms of metabolic targets regulating the progression of NAFLD is initially provided, followed by the pharmacological activity of Danshen in the management NAFLD. And then, the possible mechanisms of Danshen in the management of NAFLD based on metabolic targets are elucidated. Specifically, the metabolic targets c-Jun N-terminal kinases (JNK), sterol regulatory element-binding protein-1c (SREBP-1c), nuclear translocation carbohydrate response element–binding protein (ChREBP) related with lipid metabolism pathway, and peroxisome proliferator-activated receptors (PPARs), cytochrome P450 (CYP) and the others associated with pleiotropic metabolism will be discussed. Finally, providing a critical assessment of the preclinic and clinic model and the molecular mechanism in NAFLD.
Live-Birth Prediction of Natural-Cycle In Vitro Fertilization Using 57,558 Linked Cycle Records: A Machine Learning Perspective
Authors: Zhang Yanran , Shen Lei , Yin Xinghui , Chen Wenfeng
Published: April 2022

Background

Natural-cycle in vitro fertilization (NC-IVF) is an in vitro fertilization (IVF) cycle without gonadotropins or any other stimulation of follicular growth. Previous studies on live-birth prediction of NC-IVF were very few; the sample size was very limited. This study aims to construct a machine learning model to predict live-birth occurrence of NC-IVF using 57,558 linked cycle records and help clinicians develop treatment strategies.

Design and Methods

The dataset contained 57,558 anonymized register patient records undergoing NC-IVF cycles from 2005 to 2016 filtered from 7bsp;60,732 records in the Human Fertilisation and Embryology Authority (HFEA) data. We selected matching records and features through data filtering and feature selection methods. Two groups of twelve machine learning models were trained and tested. Eight metrics, e.g., F1 score, Matthews correlation coefficient (MCC), the area under the receiver operating characteristic curve (AUC), etc., were computed to evaluate the performance of each model.

Results

Two groups of twelve models were trained and tested. The artificial neural network (ANN) model performed the best in the machine learning group (F1 score, 70.87%; MCC, 50.37%; and AUC score, 0.7939). The LogitBoost model obtained the best scores in the ensemble learning group (F1 score, 70.57%; MCC, 50.75%; and AUC score, 0.7907). After the comparison between the two models, the LogitBoost model was recognized as an optimal one.

Conclusion

In this study, NC-IVF-related datasets were extracted from the HFEA data, and a machine learning-based prediction model was successfully constructed through this largest NC-IVF dataset currently. This model is universal and stable, which can help clinicians predict the live-birth success rate of NC-IVF in advance before developing IVF treatment strategies and then choose the best benefit treatment strategy according to the patients’ wishes. As “use less stimulation and back to natural condition” becomes more and more popular, this model is more meaningful in the decision-making assistance system for IVF.
Causal Association of Type 2 Diabetes Mellitus and Glycemic Traits With Cardiovascular Diseases and Lipid Traits: A Mendelian Randomization Study
Authors: Huang Mingkai , Laina-Nicaise Loum-Davadi , Zha Lingfeng , Tang Tingting , Cheng Xiang
Published: April 2022

Objective

We aimed to evaluate the causal effect of type 2 diabetes mellitus (T2DM) and glycemic traits on the risk of a wide range of cardiovascular diseases (CVDs) and lipid traits using Mendelian randomization (MR).

Methods

Genetic variants associated with T2DM, fasting glucose, fasting insulin, and hemoglobin A1c were selected as instrumental variables to perform both univariable and multivariable MR analyses.

Results

In univariable MR, genetically predicted T2DM was associated with higher odds of peripheral artery disease (pooled odds ratio (OR) =1.207, 95% CI: 1.162-1.254), myocardial infarction (OR =1.132, 95% CI: 1.104-1.160), ischemic heart disease (OR =1.129, 95% CI: 1.105-1.154), heart failure (OR =1.050, 95% CI: 1.029-1.072), stroke (OR =1.087, 95% CI: 1.068-1.107), ischemic stroke (OR =1.080, 95% CI: 1.059-1.102), essential hypertension (OR =1.013, 95% CI: 1.010-1.015), coronary atherosclerosis (OR =1.005, 95% CI: 1.004-1.007), and major coronary heart disease event (OR =1.003, 95% CI: 1.002-1.004). Additionally, T2DM was causally related to lower levels of high-density lipoprotein cholesterol (OR =0.965, 95% CI: 0.958-0.973) and apolipoprotein A (OR =0.982, 95% CI: 0.977-0.987) but a higher level of triglycerides (OR =1.060, 95% CI: 1.036-1.084). Moreover, causal effect of glycemic traits on CVDs and lipid traits were also observed. Finally, most results of univariable MR were supported by multivariable MR.

Conclusion

We provided evidence for the causal effects of T2DM and glycemic traits on the risk of CVDs and dyslipidemia. Further investigations to elucidate the underlying mechanisms are warranted.
Individual Identification of Large Felids in Field Studies: Common Methods, Challenges, and Implications for Conservation Science
Authors: Pereira Keren S. , Gibson Luke , Biggs Duan , Samarasinghe Dinal , Braczkowski Alexander R.
Published: April 2022

Large felids represent some of the most threatened large mammals on Earth, critical for both tourism economies and ecosystem function. Most populations are in a state of decline, and their monitoring and enumeration is therefore critical for conservation. This typically rests on the accurate identification of individuals within their populations. We review the most common and current survey methods used in individual identification studies of large felid ecology (body mass > 25 kg). Remote camera trap photography is the most extensively used method to identify leopards, snow leopards, jaguars, tigers, and cheetahs which feature conspicuous and easily identifiable coat patterning. Direct photographic surveys and genetic sampling are commonly used for species that do not feature easily identifiable coat patterning such as lions. We also discuss the accompanying challenges encountered in several field studies, best practices that can help increase the precision and accuracy of identification and provide generalised ratings for the common survey methods used for individual identification.
SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes
Authors: Jones Kyle , Ramirez-Perez Sergio , Niu Sean , Gangishetti Umesh , Drissi Hicham , Bhattaram Pallavi
Published: April 2022

SOX4 belongs to the group C of the SOX transcription factor family. It is a critical mediator of tumor necrosis factor alpha (TNF)-induced transformation of fibroblast-like s-ynoviocytes (FLS) in arthritis. In this study we investigated the genome wide association between the DNA binding and transcriptional activities of SOX4 and the NF-kappaB signaling transcription factor RELA/p65 downstream of TNF signaling. We used ChIP-seq assays in mouse FLS to compare the global DNA binding profiles of SOX4 and RELA. RNA-seq of TNF-induced wildtype and SoxC-knockout FLS was used to identify the SOX4-dependent and independent aspects of the TNF-regulated transcriptome. We found that SOX4 and RELA physically interact with each other on the chromatin. Interestingly, ChIP-seq assays revealed that 70.4% of SOX4 peak summits were within 50bp of the RELA peak summits suggesting that both proteins bind in close-proximity on regulatory sequences, enabling them to co-operatively regulate gene expression. By integrating the ChIP-seq results with RNA-seq from SoxC-knockout FLS we identified a set of TNF-responsive genes that are targets of the RELA-SOX4 transcriptional complex. These TNF-responsive and RELA-SOX4-depenedent genes included inflammation mediators, histone remodeling enzymes and components of the AP-1 signaling pathway. We also identified an autoregulatory mode of SoxC gene expression that involves a TNF-mediated switch from RELA binding to SOX4 binding in the 3’ UTR of Sox4 and Sox11 genes. In conclusion, our results show that SOX4 and RELA together orchestrate a multimodal regulation of gene expression downstream of TNF signaling. Their interdependent activities play a pivotal role in the transformation of FLS in arthritis and in the inflammatory pathology of diverse tissues where RELA and SOX4 are co-expressed.
Chronic Inflammatory Placental Disorders Associated With Recurrent Adverse Pregnancy Outcome
Authors: Cornish Emily F. , McDonnell Thomas , Williams David J.
Published: April 2022

Chronic inflammatory placental disorders are a group of rare but devastating gestational syndromes associated with adverse pregnancy outcome. This review focuses on three related conditions: villitis of unknown etiology (VUE), chronic histiocytic intervillositis (CHI) and massive perivillous fibrin deposition (MPFD). The hallmark of these disorders is infiltration of the placental architecture by maternal immune cells and disruption of the intervillous space, where gas exchange between the mother and fetus occurs. Currently, they can only be detected through histopathological examination of the placenta after a pregnancy has ended. All three are associated with a significant risk of recurrence in subsequent pregnancies. Villitis of unknown etiology is characterised by a destructive infiltrate of maternal CD8+ T lymphocytes invading into the chorionic villi, combined with activation of fetal villous macrophages. The diagnosis can only be made when an infectious aetiology has been excluded. VUE becomes more common as pregnancy progresses and is frequently seen with normal pregnancy outcome. However, severe early-onset villitis is usually associated with fetal growth restriction and recurrent pregnancy loss. Chronic histiocytic intervillositis is characterised by excessive accumulation of maternal CD68+ histiocytes in the intervillous space. It is associated with a wide spectrum of adverse pregnancy outcomes including high rates of first-trimester miscarriage, severe fetal growth restriction and late intrauterine fetal death. Intervillous histiocytes can also accumulate due to infection, including SARS-CoV-2, although this infection-induced intervillositis does not appear to recur. As with VUE, the diagnosis of CHI requires exclusion of an infectious cause. Women with recurrent CHI and their families are predisposed to autoimmune diseases, suggesting CHI may have an alloimmune pathology. This observation has driven attempts to prevent CHI with a wide range of maternal immunosuppression. Massive perivillous fibrin deposition is diagnosed when >25% of the intervillous space is occupied by fibrin, and is associated with fetal growth restriction and late intrauterine fetal death. Although not an inflammatory disorder per se, MPFD is frequently seen in association with both VUE and CHI. This review summarises current understanding of the prevalence, diagnostic features, clinical consequences, immune pathology and potential prophylaxis against recurrence in these three chronic inflammatory placental syndromes.
Lentiviral Mediated ADA2 Gene Transfer Corrects the Defects Associated With Deficiency of Adenosine Deaminase Type 2
Authors: Hong Ying , Casimir Marina , Houghton Benjamin C. , Zhang Fang , Jensen Barbara , Omoyinmi Ebun , Torrance Robert , Papadopoulou Charalampia , Cummins Michelle , Roderick Marion , Thrasher Adrian J. , Brogan Paul A. , Eleftheriou Despina
Published: April 2022

Deficiency of adenosine deaminase type 2 (DADA2) is an autosomal recessive disease caused by bi-allelic loss-of-function mutations in ADA2. Treatment with anti-TNF is effective for the autoinflammatory and vasculitic components of the disease but does not correct marrow failure or immunodeficiency; and anti-drug antibodies cause loss of efficacy over time. Allogeneic haematopoietic stem cell transplantation may be curative, but graft versus host disease remains a significant concern. Autologous gene therapy would therefore be an attractive longer-term therapeutic option. We investigated whether lentiviral vector (LV)–mediated ADA2 gene correction could rescue the immunophenotype of DADA2 in primary immune cells derived from patients and in cell line models. Lentiviral transduction led to: i) restoration of ADA2 protein expression and enzymatic activity; (ii) amelioration of M1 macrophage cytokine production, IFN-γ and phosphorylated STAT1 expression in patient-derived macrophages; and (iii) amelioration of macrophage-mediated endothelial activation that drives the vasculitis of DADA2. We also successfully transduced human CD34+ haematopoietic stem progenitor cells (HSPC) derived from a DADA2 patient with pure red cell aplasia and observed restoration of ADA2 expression and enzymatic activity in CD34+HSPC, alongside recovery of stem-cell proliferative and colony forming unit capacity. These preclinical data now expand the evidence for the efficacy of gene transfer strategies in DADA2, and strongly support clinical translation of a lentivirus-mediated gene therapy approach to treat DADA2.
SARS-CoV-2 and Multiple Sclerosis: Potential for Disease Exacerbation
Authors: MacDougall Madison , El-Hajj Sleiman Jad , Beauchemin Philippe , Rangachari Manu
Published: April 2022

While the respiratory tract is the primary route of entry for SARS-CoV-2, evidence shows that the virus also impacts the central nervous system. Intriguingly, case reports have documented SARS-CoV-2 patients presenting with demyelinating lesions in the brain, spinal cord, and optic nerve, suggesting possible implications in neuroimmune disorders such as multiple sclerosis (MS) and other related neuroimmune disorders. However, the cellular mechanisms underpinning these observations remain poorly defined. The goal of this paper was to review the literature to date regarding possible links between SARS-CoV-2 infection and neuroimmune demyelinating diseases such as MS and its related disorders, with the aim of positing a hypothesis for disease exacerbation. The literature suggests that SARS-CoV, SARS-CoV-2, and orthologous murine coronaviruses invade the CNSviathe olfactory bulb, spreading to connected structuresviaretrograde transport. We hypothesize that a glial inflammatory response may contribute to damaged oligodendrocytes and blood brain barrier (BBB) breakdown, allowing a second route for CNS invasion and lymphocyte infiltration. Potential for molecular mimicry and the stimulation of autoreactive T cells against myelin is also described. It is imperative that further studies on SARS-CoV-2 neuroinvasion address the adverse effects of the virus on myelin and exacerbation of MS symptoms, as nearly 3 million people suffer from MS worldwide.
Mechanism of Abelmoschus manihot L. in the Treatment of Contrast-Induced Nephropathy on the Basis of Network Pharmacology Analysis
Authors: Xu Zhongchi , Qian Lichao , Niu Ruge , Wang Yibei , Yang Ying , Liu Chunling , Lin Xin
Published: April 2022

Background

Contrast-induced nephropathy (CIN) is increasingly seen in patients receiving contrast medium. Abelmoschus manihot (L.) Medik. (Malvaceae) and its preparations are widely used and effective in the treatment of various chronic kidney diseases and CIN in China. It is supposed to be an important adjuvant therapy for CIN.

Methods

PubMed and CNKI were searched for the main compounds of A. manihot L. The Swiss target prediction platform, OMIM, GeneCards, DisGeNET, and DrugBank databases were mined for information relevant to the prediction of targets that A. manihot L. in the treatment of CIN. Subsequently, STRING database was applied for the construction of the PPI protein interaction network, meanwhile, the core targets were screened. DAVID database was used to perform the GO function and Kegg signal pathway enrichment analysis. AutoDockTools and PYMOAL were used for molecular docking. Vitro experiments were used to verify the effect of TFA, the main active component of A. manihot L., in the intervention of iopromide-induced cells injury.

Results

A total of 17 chemical components and 133 potential targets in A. manihot L. were obtained. The top 15 proteins with higher degree value were selected from the PPI network model, AKT1, PIK3R1, EGFR, SRC,AR, APP, TNF, GAPDH, MMP9, and PTPN1, etc. may be core targets. The enrichment analysis indicated that A. manihot L. was involved in the regulation of PI3K/AKT signaling pathway, FoxO signaling pathway, VEGF signaling pathway, HIF-1, TNF signaling pathway, melanoma, hepatitis B, and other signaling pathways which were mainly associated with the regulation of transcription and apoptosis, protein phosphorylation, inflammatory response, aging, and cell proliferation. Molecular docking indicated that the key components and core targets had a good binding ability. The vitro experiments illustrated that TFA reduces iopromide induced renal tubular cell injury and apoptosis, which may be related to regulating the phosphorylation of AKT.

Conclusion

The study preliminarily revealed the multi-component, multi-target, and multi-pathway synergistic effects of A. manihot L. on CIN, which provide theoretical reference and basis for the study of the pharmacological mechanism of A. manihot L. in the treatment of CIN.
Altered Vagal Signaling and Its Pathophysiological Roles in Functional Dyspepsia
Authors: Li Hui , Page Amanda J.
Published: April 2022

The vagus nerve is crucial in the bidirectional communication between the gut and the brain. It is involved in the modulation of a variety of gut and brain functions. Human studies indicate that the descending vagal signaling from the brain is impaired in functional dyspepsia. Growing evidence indicate that the vagal signaling from gut to brain may also be altered, due to the alteration of a variety of gut signals identified in this disorder. The pathophysiological roles of vagal signaling in functional dyspepsia is still largely unknown, although some studies suggested it may contribute to reduced food intake and gastric motility, increased psychological disorders and pain sensation, nausea and vomiting. Understanding the alteration in vagal signaling and its pathophysiological roles in functional dyspepsia may provide information for new potential therapeutic treatments of this disorder. In this review, we summarize and speculate possible alterations in vagal gut-to-brain and brain-to-gut signaling and the potential pathophysiological roles in functional dyspepsia.
Adiponectin Deficiency Enhances Anti-Tumor Immunity of CD8+ T Cells in Rhabdomyosarcoma Through Inhibiting STAT3 Activation
Authors: Peng Jiao , Huang Haifeng , Huan Qiuchan , Liao Chenghui , Guo Zebin , Hu Die , Shen Xiangchun , Xiao Haitao
Published: April 2022

Restoring the tumor-killing function of CD8+ T cells in the tumor microenvironment is an important strategy for cancer immunotherapy. Our previous study indicated that adiponectin (APN) deficiency reprogramed tumor-associated macrophages into an M1-like phenotype to inhibit rhabdomyosarcoma growth. However, whether APN can directly regulate the anti-tumor activity of CD8+ T cells remains unknown. In the present study, our results showed that exogenous APN inhibited in vitro CD8+ T cell migration as well as cytokines IFN-γ and TNF-α production. APN deficiency in vivo strengthened CD8+ T cell activation and cytotoxicity to restrain rhabdomyosarcoma, evidenced by an increase in the expression of IFN-γ and perforin in CD8+ T cells and the frequency of CD8+IFN-γ+ T cells in the spleen and lymph nodes, as well as increasing cytokine production of IFN-γ, perforin, TNF-α, and decreasing cytokine production of IL-10 in the serum. Mechanistically, STAT3 was identified as a target of APN in negatively regulating the anti-tumor activity of CD8+ T cells. In vivo, a STAT3 inhibitor remarkably increased CD8+ as well as CD8+IFN-γ+ T cells in the spleen and lymph nodes. Taken together, we substantiated that APN deficiency directly maintains the activation of CD8+ T cells to inhibit rhabdomyosarcoma growth by suppressing STAT3 activation, indicating a promising APN-based therapy for the treatment of rhabdomyosarcoma.
Current and Emerging Prognostic Biomarkers in Endometrial Cancer
Authors: Njoku Kelechi , Barr Chloe E. , Crosbie Emma J.
Published: April 2022

Endometrial cancer is the most common gynaecological malignancy in high income countries and its incidence is rising. Whilst most women with endometrial cancer are diagnosed with highly curable disease and have good outcomes, a significant minority present with adverse clinico-pathological characteristics that herald a poor prognosis. Prognostic biomarkers that reliably select those at greatest risk of disease recurrence and death can guide management strategies to ensure that patients receive appropriate evidence-based and personalised care. The Cancer Genome Atlas substantially advanced our understanding of the molecular diversity of endometrial cancer and informed the development of simplified, pragmatic and cost-effective classifiers with prognostic implications and potential for clinical translation. Several blood-based biomarkers including proteins, metabolites, circulating tumour cells, circulating tumour DNA and inflammatory parameters have also shown promise for endometrial cancer risk assessment. This review provides an update on the established and emerging prognostic biomarkers in endometrial cancer.
Genomic Prediction Can Provide Precise Estimates of the Genotypic Value of Barley Lines Evaluated in Unreplicated Trials
Authors: Terraillon Jérôme , Frisch Matthias , Falke K. Christin , Jaiser Heidi , Spiller Monika , Cselényi László , Krumnacker Kerstin , Boxberger Susanna , Habekuß Antje , Kopahnke Doris , Serfling Albrecht , Ordon Frank , Zenke-Philippi Carola
Published: April 2022

Genomic prediction has been established in breeding programs to predict the genotypic values of selection candidates without phenotypic data. First results in wheat showed that genomic predictions can also prove useful to select among material for which phenotypic data are available. In such a scenario, the selection candidates are evaluated with low intensity in the field. Genome-wide effects are estimated from the field data and are then used to predict the genotypic values of the selection candidates. The objectives of our simulation study were to investigate the correlations r(y, g) between genomic predictions y and genotypic values g and to compare these with the correlations r(p, g) between phenotypic values p and genotypic values g. We used data from a yield trial of 250 barley lines to estimate variance components and genome-wide effects. These parameters were used as basis for simulations. The simulations included multiple crossing schemes, population sizes, and varying sizes of the components of the masking variance. The genotypic values g of the selection candidates were obtained by genetic simulations, the phenotypic values p by simulating evaluation in the field, and the genomic predictions y by RR-BLUP effect estimation from the phenotypic values. The correlations r(y, g) were greater than the correlations r(p, g) for all investigated scenarios. We conclude that using genomic predictions for selection among candidates tested with low intensity in the field can proof useful for increasing the efficiency of barley breeding programs.
Long-Term High-Temperature Stress Impacts on Embryo and Seed Development in Brassica napus
Authors: Mácová Kateřina , Prabhullachandran Unnikannan , Štefková Marie , Spyroglou Ioannis , Pěnčík Aleš , Endlová Lenka , Novák Ondřej , Robert Hélène S.
Published: April 2022

Brassica napus (rapeseed) is the second most important oilseed crop worldwide. Global rise in average ambient temperature and extreme weather severely impact rapeseed seed yield. However, fewer research explained the phenotype changes caused by moderate-to-high temperatures in rapeseed. To investigate these events, we determined the long-term response of three spring cultivars to different temperature regimes (21/18°C, 28/18°C, and 34/18°C) mimicking natural temperature variations. The analysis focused on the plant appearance, seed yield, quality and viability, and embryo development. Our microscopic observations suggest that embryonic development is accelerated and defective in high temperatures. Reduced viable seed yield at warm ambient temperature is due to a reduced fertilization rate, increased abortion rate, defective embryonic development, and pre-harvest sprouting. Reduced auxin levels in young seeds and low ABA and auxin levels in mature seeds may cause embryo pattern defects and reduced seed dormancy, respectively. Glucosinolates and oil composition measurements suggest reduced seed quality. These identified cues help understand seed thermomorphogenesis and pave the way to developing thermoresilient rapeseed.
Learning About Your Mental Health From Your Playlist? Investigating the Correlation Between Music Preference and Mental Health of College Students
Authors: Wang Kun , Gao Sunyu , Huang Jianhao
Published: April 2022

The present study explored the correlation between music preference and mental health of college students to make an empirical contribution to research in this field. The self-reported music preference scale and positive mental health scale of college students were adopted to conduct a questionnaire survey in college students. Common method variance was conducted to test any serious common method bias problem. No serious common method bias problem was observed. The results showed that college students’ preference for pop music, Western classical music, and Chinese traditional music has a significant and positive correlation with their mental health. Furthermore, college students’ preference for heavy music has a significant and inverse correlation with their mental health. This research presents a correlational study; therefore, no causality can be inferred.
Burnout and Maladjustment Among Employed Students
Authors: Drăghici Gabriela-Lăcrămioara , Cazan Ana-Maria
Published: April 2022

Stress and burnout are present in every aspect of an individual’s life, and the growing number of employed students raises certain concerns about their engagement in academic tasks and finishing their studies. Our study aims to analyze the differences between student burnout in different contexts, work- and academic-related burnout, and examine the predictive role of burnout in academic maladjustment, including test anxiety as a mediator and occupational status as a moderator. The sample consisted of 151 students from different universities in Romania. Consistent with previous studies, the results showed that academic burnout is higher than work-related burnout. High levels of test anxiety explain high levels of academic burnout, which in turn explains low levels of academic adjustment. The results highlight the mediating role of anxiety in the relationship between academic burnout and academic maladjustment with occupational status as a moderator. Future research should focus on the type of students’ job, the mediating relationship between self-efficacy and academic burnout, and the relationship between burnout and personality traits.
Children Treat Grammatical Errors Differently for Native and Non-Native Speakers
Authors: Rett Alexandra , White Katherine S.
Published: April 2022

Both children and adults demonstrate biases against non-native speakers. However, in some situations, adults act more generously towards non-native speakers than towards native speakers. In particular, adults judge errors from non-native speakers less harshly, presumably because they expect such errors. In the present study, we asked whether 5-6-year-old children place less weight on errors from speakers with a foreign accent. In Experiment 1, 5- and 6-year-old children (N = 80) listened to pairs of either native or foreign-accented speakers (between-subjects) label objects. For native speaker pairings, children preferred information provided by grammatical speakers over information from speakers who made subject-verb agreement errors. In contrast, children chose between foreign-accented speakers at chance. In Experiment 2 (N = 40), children preferred information from grammatical foreign-accented speakers over information from foreign-accented speakers who produced word-order violations. These findings constitute the first demonstration that children treat speech errors differently based on a speaker’s language background.
Research on the Construction of Emergency Network Public Opinion Emotional Dictionary Based on Emotional Feature Extraction Algorithm
Authors: Hui Fang
Published: April 2022

How to strengthen emergency management and improve the ability to prevent and respond to emergencies is an important part of building a harmonious socialist society. This paper proposes a domain emotion dictionary construction method for network public opinion analysis of public emergencies. Using the advantages of corpus and semantic knowledge base, this paper extracts the seed words based on the large-scale network public opinion corpus and combined with the existing emotion dictionary, trains the word vector through the word2vec model in deep learning, expands the emotion words, and obtains the candidate emotion words according to the semantic similarity calculation, So as to generate a domain emotion dictionary. The accuracy rate of emotion discrimination by the emotion dictionary constructed in this paper is 0.86, the recall rate is 0.92. Through the verification of accuracy and recall rate, the construction method proposed in this paper has good accuracy and reliability. Because of the great differences in different experiences and situations of different groups, there will be great differences in views and perspectives on the same event. The key to prevent the public from blindly following the crowd should be to reach groups close to emotional distance, and targeted prevention and control of public opinion can be conducted according to different characteristics of different groups.
The Effect of Risk Prevention Ability on Entrepreneurial Performance of Chinese College Students: Moderating Effect of Team Management Ability
Authors: Zhu Yuting , Qu Shaowei , Jin Hebo , Li Zhaohui
Published: April 2022

Improving the performance and success rate of college students’ new ventures has attracted increasing attention globally. In this study, a questionnaire survey was conducted among 1500 college students who were directly involved in entrepreneurial activities in 23 provinces in China. The study explores the effects of team management and risk prevention abilities on college students’ entrepreneurial performance. The results show that risk prevention ability significantly increases university students’ entrepreneurial performance (e.g., profit and loss status, capital flow, and staff flow). Team management ability enhances these entrepreneurial indicators to varying degrees, with a “threshold” effect of its impact on entrepreneurial performance. With a continued increase in team management ability, the effect of risk prevention ability on entrepreneurial performance becomes increasingly more significant. Specifically, when team management ability reaches a medium level and above, risk prevention ability significantly improves capital flow and staff stability; and when team management ability reaches a high level, risk prevention ability significantly improves enterprise profitability indicators.
Student Counseling Centers in Europe: A Retrospective Analysis
Authors: Franzoi Isabella Giulia , Sauta Maria Domenica , Carnevale Giuliano , Granieri Antonella
Published: April 2022

Objective

Tertiary education can be stressful for many young people, who consistently report high levels of distress. The issue has major implications for campus health services and mental health policymaking more widely. The present study proposes to map student counseling services in Europe.

Methods

The sample of institutions was sourced, using standardized data extraction, from the European Tertiary Education Register (ETER). Then, each institution’s website was analyzed for information about the availability of student counseling centers and the services provided. Data extracted from the ETER database were: ETER ID, national identifier, institution name, English institution name, number of students, legal status (in English), institution category (in English), and institutional website. Data extracted from institutions’ websites concerned the availability of students’ psychological centers and the services provided. Analyses were carried out using the SPSS Statistics software package (IBM Corp., Armonk, NY, United States), version 26.

Results

Overall, it was found that most institutions do not provide mental health counseling services for their students. Institutions of medium dimensions showed a higher probability of reporting students’ psychological centers than small institutions. Moreover, private institutions and public institutions were more likely to report having such centers, while private government-dependent institutions were less likely. Universities of applied sciences and universities were more likely to report having them, while other institutions were less likely. Regarding provision according to geographic area, compared to Northern Europe, every other European region was less likely to report featuring such centers. Most institutions reported offering counseling, career counseling, or not otherwise specified psychological services, but only a small number reported providing services such as psychotherapy, psychiatric services, or counseling for learning-specific disabilities.

Conclusion

It is critically important to catalog European data on student counseling centers and services, to encourage tertiary education institutions to invest in such services as key sites for mental health promotion. Indeed, professionally trained staff and the possibility of long-term treatment options would go a long way in supporting students who might not otherwise have access to treatment.
Is It a Gut Feeling? Bodily Sensations Associated With the Experience of Valence and Arousal in Patients With Inflammatory Bowel Disease
Authors: Atanasova Konstantina , Lotter Tobias , Bekrater-Bodmann Robin , Kleindienst Nikolaus , Reindl Wolfgang , Lis Stefanie
Published: April 2022

Background

Previous studies have shown dysfunctional emotion processing in patients with inflammatory bowel diseases (IBD), characterized by a hypersensitivity to negative emotions and a hyposensitivity to positive emotions. Models of emotion processing emphasize the importance of bodily sensations to the experience of emotions. Since there have been no studies on whether emotion-associated bodily sensations are changed in IBD, we investigated the experience of bodily sensations related to valence and arousal, together with their links to emotional awareness, as one domain of interoceptive sensibility relevant to emotion processing.

Methods

Using a topographical self-report measure, 41 IBD patients in clinical remission and 44 healthy control (HC) participants were asked to indicate where and how intensely in their body they perceive changes when experiencing emotions of positive and negative valence, as well as relaxation and tension. Additionally, we used self-report questionnaires to assess emotional awareness as one domain of an individual’s interoceptive sensibility, gastrointestinal-specific anxiety (GSA), and psychological distress.

Results

Patients with IBD reported higher emotional awareness but lower intensities of perceived changes in their bodily sensations related to valence and arousal of emotional processing. IBD patients reported less intense bodily activation during positive emotions and less intense bodily deactivation during negative emotional states in comparison to HC participants. Higher emotional awareness and psychological distress were linked to stronger experiences of emotion-related bodily sensations in IBD patients.

Conclusion

Inflammatory bowel diseases patients exhibited alterations in how they link bodily sensations to their emotional experience. Such persistent changes can affect a patient’s wellbeing and are related to higher levels of anxiety and depression among IBD patients, even in remission.