bluuebunny/crossref_metadata_2025 huggingface dataset:
Re- diseñando el espacio público patrimonial.
Authors: Moreno Sánchez Elian Coral
Published: November 2020

El presente ensayo plantea el potencial que tiene el parque vecinal para ser experimentado y apropiado por su población desde una perspectiva de sus actores sociales, siendo el caso de estudio el parque de la colonia Unidad Panamericana en Ciudad Juárez, Chihuahua el cual cuenta con la característica del envejecimiento demográfico de sus residentes. Con base a lo anterior se analizó la tendencia histórica de esta ciudad fronteriza en cuanto a espacio público abierto relativo a parques vecinales y sus políticas públicas orientadas hacia el adulto mayor, actualmente protagonistas de su utilización, debido a que su número se incrementa de modo significativo y cuentan con una mayor disponibilidad de tiempo, finalmente se presentan recomendaciones de diseño para el equipamiento del sitio incorporando la experiencia y participación de las personas mayores así también se presenta la conceptualización teórica referente a taller de proyecto arquitectónico y participativo de la Universidad Autónoma de Ciudad Juárez que tomo parte en la realización de propuestas puntuales para mejorar la calidad de vida del sitio.
PELATIHAN SERVIS SEPEDA MOTOR TIPE KARBURATOR UNTUK KARANG TARUNA DESA SRIKAMULYAN, KECAMATAN TIRTAJAYA, KABUPATEN KARAWANG
Authors: Amir
Published: November 2020

Desa Srikamulyan terletak di Kecamatan Tirtajaya, Kabupaten Karawang, Propinsi Jawa Barat dengan jumlah penduduk 7.381 orang yang terdiri dari 3.742 laki-laki dan 3.639 perempuan. Rendahnya tingkat pendidikan masyarakat di desa ini merupakan salah satu faktor yang berkonstribusi memberikan rendahnya tingkat perekonomian desa. Masalah yang dihadapi mitra adalah banyak pemuda yang putus sekolah di usia produktif yang tidak mempunyai keahlian tambahan sehingga tidak mempunyai peluang untuk mencari kerja yang menyebabkan meningkatnya angka pengangguran. Berdasarkan hal diatas dengan memperhatikan kondisi desa tersebut, maka solusi yang ditawarkan untuk mengatasi permasalahan tersebut adalah dengan memberikan pelatihan dibidang otomotif khususnya sepeda motor. Metode pelatihan ini yang meliputi teori dan praktek yang di ikuti peserta karang Taruna desa Srikamuyan dan mengikuti program pelatihan ini berjumlah 15 orang di mana para peserta semua adalah pemuda karaang taruna Desa. Berdasarkan hasil evaluasi Teori dan Praktek, maka keseluruhan peserta peltihan dapat memahami tentang sevis kendaraan sepedah motornya tanpa harus dibawa kebengkel seluruh peserta sudah memahami baik teori maupun praktek yaitu membongkar, menyetel dan memasang karburator sepeda motor.

Kata kunci: Sepeda motor,servis, komponen, ketrampilan.

 

Srikamulyan Village is located in Tirtajaya District, Karawang Regency, West Java Province with a population of 7,381 people consisting of 3,742 men and 3,639 women. The low level of community education in this village is one of the factors contributing to the low level of the village economy. The problem faced by partners is that many youth who drop out of school at productive age do not have additional skills so that they do not have the opportunity to find work which causes an increase in the unemployment rate. Based on the above, taking into account the conditions of the village, the solution offered to overcome this problem is to provide training in the automotive sector, especially motorbikes. This training method includes theory and practice that the participants of the Srikamuyan village youth organization and participate in this training program totaling 15 people in which the participants are all young Karaang Village cadets. Based on the results of the evaluation of theory and practice, all training participants can understand about the service of motorbikes without having to be taken to the workshop, all participants have understood both theory and practice, namely dismantling, tuning and installing carburetors on motorbikes.

Keywords: Srikamulyan village, service, motorcycle maintenance, carburetors
The perceived contributions of non-physician team members to residents’ interprofessional education during a critical care rotation
Authors: Landriault Angele , McMurtry Angus
Published: November 2020

Background: During rotations, post-graduate medical residents must learn about interprofessional teamwork and collaboration. Our study examined the role of non-physician healthcare team members in such education, from the perspectives of both residents and team members themselves.
Methods: This qualitative study took place in the intensive care unit (ICU) of a teaching hospital in a Canadian city. We conducted semi-structured individual and focus group interviews with both residents (n = 6) and the team members with whom they collaborated: pharmacists, nurses, respiratory therapists, and a social worker (n = 19).
Results: We developed a number of themes about interprofessional education (IPE) in this context from the data, including the presence of planned, unplanned, and tacit teaching; the influence of contextual factors like ICU culture, work demands, resident motivation, power hierarchies, and perceptions of ‘good’ and ‘bad’ residents; the gap between team member perceptions of their contribution to residents’ IP education and residents’ own perceptions; and concerns about the transferability of IPE to other contexts.
Conclusions: The influence of non-physician team members on residents’ IPE in the clinical environment is an understudied topic. While our study was limited to one ICU, the themes that emerged may be of interest to others in similar contexts.
Las ideas y las prácticas. Agenda de gobierno y régimen de políticas universitarias en México
Authors: Acosta Silva Adrián
Published: November 2020

El texto es un esfuerzo por identificar la agenda, los cambios y las tensiones observadas en la primera etapa del gobierno federal encabezado por Andrés Manuel López Obrador en el Campo Universitario Mexicano. El análisis descansa en la perspectiva de “Régimen de Políticas”, que focaliza la atención en las ideas, los arreglos institucionales y los actores principales en el diseño e implementación de las políticas públicas. El argumento central a discusión es que el nuevo gobierno no se ha orientado hasta el momento en la construcción de un nuevo régimen de políticas, mostrando una clara tendencia hacia la continuidad de políticas anteriores, pero también un nuevo contexto político, de austeridad financiera y redistribución presupuestal de los programas y recursos públicos en la educación superior.
Sustainable Activities of Universities: Experience from the Open Access Articles in the Economic Subject Area
Authors: Šipilova Viktorija
Published: November 2020

Following to the global trends, the future role of sustainable universities will expand with the new focuses as, for example, entrepreneurial activities and Open Science. Entrepreneurial activities of universities provide possibilities to contribute to sustainability and Open Science is the tool for fast and simultaneous spread and exchange of the newest knowledge and good practices. This research focuses on three questions – how widespread economically oriented sustainable activities of universities are, which activities universities prefer as sustainable and economically oriented, and how often universities share such knowledge through Open Access articles. For the purpose, the author applies the monographic method, the logical analysis method, and the scientific induction method for the study of the selected Open Access articles about sustainable activities of universities in the economic subject area. Research findings indicate that the idea about sustainable and economically oriented activities of universities is widespread around the world and there are case studies from Europe, North America, Asia, and Africa. The analysis demonstrates differentiated accents in sustainable economically oriented activities of universities – globally accepted sustainability goals in economic sphere, entrepreneurial ecosystems, topicality of sustainability content in education for participants of labour market, new teaching approaches, transdisciplinary research, and university as sustainable and competitive participant at the market. Although, it is noteworthy to highlight that the exchange of knowledge and practice through Open Access articles in the relevant subject area is relatively modest and requires more attention from universities.
The Significant Effect of Leadership and Conflict Management on Job Satisfaction
Authors: Anastasiou Sophia
Published: November 2020

The purpose of this work is to present evidence which illustrate the significant effect of leadership and conflict management on employee satisfaction in a range of professions. Leadership and conflict management have a significant effect on job satisfaction. This is illustrated with examples of the interaction between these parameters in a range of professions. It is worth noting that a significant effect of leadership is exhibited in a range of different professional sectors and groups of employees, reflecting the universal value of leadership interacting with a wide range of parameters which may vary according to age, level of education, working conditions, cultural differences and employee expectations. Irrespective of the complexity and variety of determinant parameters, the effect of leadership and conflict management on job satisfaction has been widely exhibited in the reviewed data of the present analysis. Motivated and satisfied employees are a key in achieving organizational goals and leaders should take into account factors related to work performance, motivation and job satisfaction.
Maintaining Ethnicity and Social Networks: Engkor Lorgow, Lion, Dragon Dance, Performing Arts of the Chinese Ethnic Group in Udonthani Province
Authors: Ieamkaew Chiraphan , Singyabuth Supachai , Chantamala Ourarom
Published: November 2020

The research titled “Maintaining Ethnicity and Social Networks: Engkor Lorgow, Lion, Dragon Dance Performing Arts of the Chinese Ethnic Group in Udonthani Province” was qualitative research that emphasized on investigated and collected data from the field study, document, and related research and presented in descriptive analysis, particularly at Thung Si Muang Annual Festival in 2018. The objectives of the study consisted of three criteria: 1) to study of the development of the Chinese ethnic group in Udonthani, 2) to analyze the role of the Engkor Lorgow, Lion, Dragon Dance Performing Arts in maintaining ethnicity and social network of Chinese ethnic group in Udonthani, and 3) to analyze how the culture of Engkor Lorgow, Lion, Dragon Dance Performing Arts helped created social group between Chinese ethnic group and the local people in Udonthani. The study results found that the Engkor Lorgow, Lion, Dragon Dance was part of the ritual at Chao Pu-Ya shrine. The Chinese ethnic group worked together on the ceremony by holding the Chinese Opera to show the belief and faith of traditional Chinese culture and to gather all Chinese together to maintain their ethnicity and create social networks with one another. Chinese Operas were held annually in Thung Si Muang, Udonthani province, Thailand, and had adapted the Engkor Lorgow, Lion, Dragon Dance to be more spectacular and fit in with social contexts in Udonthani. The dance was promoted to be one of the provincial identities and played an important role in tourism in Udonthani. Thus, the Engkor Lorgow, Lion, Dragon Dance has been a ritual that helped assemble and created social networks between the Chinese ethnic group and other ethnic groups in Udonthani province.
Trade and Economic Cooperation of BRICS: Problems and Prospects
Authors: Yarygina I. Z. , Zhiglyaeva A. V. , Vershinina O. V. , Kuvshinova Yu. A.
Published: November 2020

The subject of this study is the legal and financial features of the BRICS trade and economic cooperation and the practice of their application in modern conditions.  The purpose of this article is to identify problems that impede the effective development of economic relations and put forward proposals for their improvement.  The study showed that the BRICS countries have significant reserves for multilateral cooperation and support of trade and economic relations.  In this regard, harmonization of trade and economic relations of partner countries is necessary, in order to solve strategic problems and improve the living standards of the population.  It is shown that simplifying the access of entrepreneurs to credit, tax incentives for exporters of industrial goods, flexible conditions for direct and indirect financing of projects and programs, expanding the participation of BRICS development banks and institutional investors contributes to the progressive development of national economies and improving trade and economic relations of BRICS. For research purposes, IBOV INDEX (Brazil), CRTX INDEX (Russia), SENSEX INDEX (India), SHCOMP INDEX (China), JALSH INDEX (South Africa) and Bloomberg platform (WEI, DES, GP, XLTP XCIT, MEMB) materials were used. Evaluation of data in key sectors of the BRICS economies showed the existence of interconnectedness and interdependence of the BRICS trading floor indices - sources of direct financing for trade and economic cooperation of partner countries.  Correlation analysis and cointegration of time series confirmed a solid foundation for stimulating multilateral cooperation of the BRICS, including on the basis of interstate support for business entities and expanding the participation of institutional investors in ensuring sustainable development of the BRICS. It is concluded that the results of the study can be used in developing measures of interstate support for trade and economic cooperation of BRICS in modern conditions.
Implementation of Intellectual Property Right to Strengthen Small and Medium-Sized Enterprise Business Capacity in Global Competition
Authors: Suparji
Published: November 2020

This study aims to analyze the role of MSMEs in the Indonesian economy and the implementation of Intellectual Property Rights (IPR) in protecting Micro, Small and Medium Enterprises (MSMEs). Qualitative analysis is done by interpreting the data collected from library studies with the aim of solving research problems. The result showed that the protection of IPR in MSMEs can increase its business capacity and be able to compete in global competition, because goods and services have exclusive rights and economic rights. With the protection of IPR, stakeholders will strengthen MSMEs and participate in developing the MSME capacity. The banks can provide credit loans with collateral for IPR assets owned by MSMEs.
Awareness about Autism Spectrum Disorder (ASD) among Parents of Typically Developing Children
Authors: Hemdi Alyaa
Published: November 2020

Autism spectrum disorder (ASD) is a neurodevelopmental disorder common among children. Special attention is frequently given to the early detection of ASD for early treatment implementation, which improves these children’s outcomes. Enhanced public awareness is necessary to prevent delays in the provision of such services by aiding the early identification of cases. There is a lack of studies that determine ASD awareness among parents of typically developing children (TDC). Therefore, the aim of this study was to comprehend the extent of ASD awareness and knowledge among Saudi parents of TDC. A cross-sectional descriptive survey using a questionnaire was distributed to survey 232 Saudi parents’ (98 female, 134 male) ASD awareness and knowledge. Overall, this study’s results showed that ASD awareness among Saudi parents is good, as the study participants were knowledgeable about its aetiology, signs and symptoms. However, there are still misconceptions and lacking of knowledge that need to be addressed. Interestingly, the fathers were found to be more knowledgeable about general ASD information and aetiology than the mothers. The findings showed that around 49.1% of Saudi parents do not know if vaccinations cause ASD, which indicates lacking awareness in this regard. Despite the efforts of different sectors to raise ASD awareness in the KSA, more work needs to be done to address misconceptions among parents. This is necessary to aiding the early detection and identification of ASD, which will expedite services’ provision for better outcomes for children with ASD.
Accommodating Minorities into Sri Lanka’s Post-Civil War State System: Government Initiatives and Their Failure
Authors: Fazil Mansoor Mohamed , Fowsar Mohamed Anifa Mohamed , Kamalasiri Vimalasiri , Sajeetha Thaharadeen Fathima , Sakki Mohamed Bazeer Safna
Published: November 2020

Many observers view the defeat of the Liberation Tigers of Tamil Eelam (LTTE) in May 2009 as a significant turning point in the protracted ethnic conflict that was troubling Sri Lanka. The armed struggle and the consequences of war have encouraged the state and society to address the group rights of ethnic minorities and move forward towards state reconstitution. The Tamil minority and international community expect that the Government of Sri Lanka (GOSL) must introduce inclusive policies as a solution to the ethnic conflict. They believe the state should take measures to avoid another major contestation through the lessons learned from the civil war. The study is a qualitative analysis based on text analysis. In this backdrop, this paper examines the attempts made for the inclusion of minorities into the state system in post-civil war Sri Lanka, which would contribute to finding a resolution to the ethnic conflict. The study reveals that numerous attempts were made at various periods to introduce inclusive policies to achieve state reconstitution, but those initiatives failed to deliver sustainable peace. The study also explores problems pertaining to contemporary policy attempts.
PENERAPAN MODEL PROBLEM SOLVING LEARNING UNTUK MENINGKATKAN MOTIVASI BELAJAR DAN PEMAHAMAN KONSEP PELUANG SISWA SMK PERSADA WAJO
Authors: Henra Kiki
Published: November 2020

Penggunaan metode pembelajaran yang klasik menyebabkan kurangnya motivasi dan pemahaman konsep siswa merupakan permasalahan yang ditemui pada siswa kelas XI SMK Persada Tahun Pelajaran 2018/2019. Terkait dengan permasalahan yang ditemukan maka peneliti menerapkan pembelajaran problem solving learning (PSL) merupakan pembelajaran yang memiliki sintaks yang diterapkan secara eksplisit untuk memberi siswa waktu lebih lama untuk berpikir, menjawab dan bekerjasama satu sama lain, dimana tujuan dari penelitian ini adalah untuk mengetahui tingka motivasi dan pemahaman konsep peluang siswa kelas XI SMK Persada Tahun Pelajaran 2018/2019. Penelitian ini adalah penelitian tindakan kelas (PTK) yang bertujuan untuk memperbaiki proses pembelajaran. Instrumen dan teknik pengumpulan data dilakukan dengan lembar obervasi, angket motivasi dan tes kemampuan pemahaman konsep siswa. Berdasarkan analisis data penelitian diperoleh hasil evaluasi kemampuan pemahaman konsep siswa pada siklus I adalah persentase ketuntasan belajar secara klasikal yang dicapai 62,5% dengan nilai rata-rata 66,67 hasil evaluasi siklus II adalah 92,00% dengan nilai rata-rata 76,72, tingkat motivasi belajar siswa pada siklus I mencapai 51,95% dengan kategori sedang dan pada siklus II mencapai 74,00% dengan kategori tinggi. Jadi hasil penelitian yang didapatkan semakin meningkat dari tiap siklus. Dari hasil evaluasi dapat disimpulkan bahwa penerapan problem solving learning (PSL) untuk meningkatkan motivasi dan pemahaman konsep peluang siswa kelas XI SMK Persada Tahun Pelajaran 2018/2019
Regional aspects of acceptation of the new subjects in the Slovak political arena
Authors: Mariot Peter
Published: November 2020

The author observes specific features of the regional picture of support to five political parties, which emerged as new and obtained chairs in the Slovak Parliament in the years 1999-2002 (Tab. 1). He uses the index of openness (Io) computed for each community as the sum of bal values for the individual parties (Tab. 5) to express regional differences in the willingness of voters in different regions of the Slovak Republic to accept these new political subjects. The communities with a high index of openness values (Io from 20 to 29) are found above all in the administrative region of Košice (Fig. 6), while the "openness" of electors increases from the west to the east and with increasing population in the settlements of the Slovak Republic.
Evaluation of effectiveness and efficiency of regional policy programmes: Analysis of ex ante evaluations of programming documents
Authors: Hartlová Martina
Published: November 2020

The paper focuses on evaluation of regional policy programmes in the European Union and in the Czech Republic as a tool for improving effectiveness and efficiency of the regional policy. The main methodological problems and conceptual questions are summarized as well as the current situation of evaluation practice in the EU. A special attention is also dedicated to the existing experience of the Czech Republic in this area, in particular in the ax ante evaluation. Finally, the paper presents several possible solutions for the future evaluation development that could result in the improvement of the regional policy in the Czech Republic.
Protection of Individuals in the light of EU Regulation 2016/679 on the Protection of Natural Persons with Regard to the Processing of Personal Data and on the Free Movement of such Data
Authors: Tokarski Mirosław
Published: November 2020

The process of establishing normative acts in the European Union does not  occur out of nowhere, but in the context of specific social needs. That was the case of the genesis of establishing legal regulations regarding the protection of personal data in the European Union. Socio-economic integration, which resulted from the functioning of internal market in the European Union, has led to a significant increase in cross-border transfers of personal data. It led to situation in which various economic operators or state institutions of the Member States have increasingly processed the personal data of the EU citizens. Within time, these data have become an equally valuable commodity - not to say even more valuable – compared to goods and services (Costa-Cabral, and Lynskey Orla, 2017, p. 11). Making use of personal data on a large scale especially by public and private entities, associations and companies over time has posed a threat to the security of personal data. This has made it necessary to introduce legal protection measures for personal data in the European Union that would eliminate the negative effects of any form of personal data processing. The purpose of this article is to evaluate legal regulations regarding legislative protection of personal data in the European Union against the background of EU Regulation 2016/679 of the European Parliament and the Council with respect to the protection of individuals due to processing personal data, its free movement and repealing Directive 95/46/EC (hereinafter referred to as Regulation 2016/679). Due to initially adopted purpose of the considerations there arose a problem which was formulated in the form of a question: Do the legal measures introduced by the Regulation constitute an effective tool for the protection of personal data in the event of a violation of the law by personal data administrators and entities while processing such data? The presented purpose of the considerations and the research problem determined the order of the analysis.
Eksistensi Kedaulatan Rakyat dan Implementasi Parliamentary Threshold dalam Sistem Pemilihan Umum di Indonesia
Authors: Bachmid Fahri
Published: November 2020

Penelitian ini bertujuan untuk menguraikan lebih lanjut tentang pemberlakuan parliamentary threshold dalam sistem Pemilu, serta pertentangannya dengan konsep kedaulatan rakyat. pendekatan normatif, yang dimana bukan hanya mengkaji hukum dalam arti peraturan perundang-undangan semata, akan tetapi meliputi aspek yang lebih luas, yaitu sesuatu yang dapat ditelusuri melalui bahan kepustakaan. Teknis analisis yang digunakan dalam penelitian ini adalah metode analisis hermeneutik dan interpretasi. Hasil penelitian menunjukkan bahwa pemberlakuan parliamentary threshold dalam sistem Pemilu di Indonesia bertentangan dengan konsep kedaulatan rakyat. Adapun penerapan sistem khususnya pada Pemilu 2024, patut mempertimbangkan sistem Campuran sebagai alternatif dari sistem Representasi Proporsional yang selama ini diterapkan pada Pemilu di Indonesia. Selanjutnya, dibutuhkan formulasi khusus dimana Partai Politik Peserta Pemilu yang dinyatakan tidak memenuhi ambang batas dapat menempuh jalur koalisi untuk mencapai ambang batas, bahkan sampai pada pilihan untuk meniadakan parliamentary threshold (ambang batas perolehan suara 0%). Hal ini akan menjadi jalan tengah atas kebutuhan pencapaian proporsionalitas sistem Pemilu, sebagai bentuk akomodasi suara pemilih serta kepastian hukum atas kedaulatan rakyat, serta kebutuhan menciptakan sistem Presidensialisme yang semakin efektif di masa yang akan datang
Clinical Pharmacology and Therapeutics of Antiepileptic Drugs
Authors: Reddy Samba
Published: November 2020

This article describes clinical antiepileptic drugs (AEDs) that are available for treatment of epilepsy. Epilepsy is characterized by repeated occurrence of seizures. Epileptic seizures are classified into focal onset (partial) and generalized onset (generalized) types. Around two-dozen AEDs are available for treating epilepsy. AEDs act on diverse molecular targets to selectively modify the abnormal excitability of neurons by reducing the focal seizure discharges or preventing spread of excitation. AEDs suppress seizures by blocking the voltage-gated sodium channels (phenytoin, carbamazepine, valproate, lamotrigine, oxcarbazepine, topiramate), voltage-activated calcium channels (ethosuximide, gabapentin), potentiation of GABA inhibition (barbiturates, benzodiazepines, tiagabine), and reduction of glutamate excitation (felbamate, parampanel). Carbamazepine, phenytoin, and valproate are the first-line agents for partial onset seizures and generalized onset seizures. Ethosuximide is the drug of choice for absence seizures. AEDs are orally-active and show unique PK features. Some AEDs cause enzyme induction and hence produce drug-drug interactions. Newer AEDs such as gabapentin, levetiracetam, tiagabine, and pregabalin do not cause enzyme induction. Despite many advances in AEDs, nearly 30% of people with epilepsy have drug-resistant or intractable seizures. Presently, there is no cure for epilepsy. Thus, newer and better AEDs that can better prevent refractory seizures and modify the disease are needed for curing epilepsy.
Antioxidant and Analgesic Activity of Acer laevigatum Wall, a Traditional Mizo-tribe Medicine
Authors: Ralte Andrew Lalthasanga , Lapasam Phaibiang , Nongkhlaw Freddy Teilang , Kyndait Pdiangmon , Zothanpuia
Published: November 2020

Acer laevigatum is an evergreen tree growing to a height of 10–15 m or more, with a trunk up to 50 cm diameter belonging to the family Sapindaceae. In Mizoram, the decoction of the leaves is used as an external application in sprains. Extraction was carried out by drying the leaves and barks and extracted by using methanol as solvent using the Soxhlet apparatus. Preliminary phytochemical screening was carried out by methanolic extract of both leaves and barks to determine the chemical constituents present in the plant using a different phytochemical test, acute toxicity for leave and bark extract, in-vitro antioxidant activity and in-vivo analgesic activity of barks extract. Phytochemical screening was performed for both extract and it contains glycoside, saponin, phenol, tannin, flavonoid, and steroid. The antioxidant activity test of the methanolic extract of bark extract was performed successfully. In acute toxicity, the LD50 was found that for more than 2000 mg/kg body weight was safe for further uses. The total phenolic content of the bark extract contains 493 ± 0.23 mg of GAE/g and the total flavonoids content of the bark extract was 220 ± 0.034 mg of QE/g. The IC50 value of DPPH free radical scavenging activity was found to be 86.1211 µg/ml and nitric oxide was 75.9 µg/ml. Whereas, in reducing power it was found that the percentage inhibition was increased with an increase in concentration (increase in concen-tration, percentage inhibition was also increased) and reduced Fe3+ (ferricyanide complex) to Fe2+ (ferrous form). Finally, for in-vivo analgesic activity, 4000 mg/kg was more effective than 2000 mg/kg of the bark extract. These results confirm that the methanolic extract of bark of Acer laevigatum possesses antioxidant activity and non-significant or less analgesic activity.
Application of Plakett-Burman Screening Design in Optimization of Process Parameters for Formulation of Canaglifozin Nanosuspension
Authors: Patel Nisha , Patel Hitesh A
Published: November 2020

In this study, we sought to improve the dissolution characteristics of a poorly water-soluble BCS class IV drug canaglifozin, by preparing nanosuspension using media milling method. A Plackett–Burman screening design was employed to screen the significant formulation and process variables. A total of 12 experiment were generated by design expert trial version 12 for screening 5 independent variables namely the amount of stabilizer in mg (X1), stirring time in hr (X2), amt of Zirconium oxide beads in gm (X3), amount of drug in mg (X4) and stirring speed in rpm (X5) while mean particle size in nm (Y1) and drug release in 10 min. were selected as the response variables. All the regression models yielded a good fit with high determination coefficient and F value. The Pareto chart depicted that all the independent variables except the amount of canaglifozin had a significant effect (p<0.001) on the response variables. The mathematical model for mean particle size generated from the regression analysis was given by mean particle size = +636.48889 -1.28267 amt of stabilizer(X1) -4.20417 stirring time (X2) -7.58333 amt of ZrO2 beads(X3) -0.105556 amt of drug(X4) -0.245167 stirring speed(X5) (R2=0.9484, F ratio=22.07, p<0.001). Prepared canaglifozin nanosuspension exemplified a significant improvement (p<0.05) in the release as compared to pure canaglifozin and marketed tablet with the optimum formulation releasing almost 80% drug within first 10min. Optimized nanosuspension showed spherical shape with surface oriented stabilizer molecules and a mean particle diameter of 120.5 nm. There was no change in crystalline nature after formulation and it was found to be chemically stable with high drug content.
Method Development and Validation of Stability Indicating HPLC Assay for the Determination of Tenofovir Alafenamide Fumarate in Tablet Formulation
Authors: Agrawal Deeksha , Dahiya Meenakshi , Wakode Sharad , Singh Gaurav P , Shiv Jai
Published: November 2020

his manuscript describes the development and validation of a simple, isocratic, precise and accurate HPLC method for the assay of Tenofovir alafenamide fumarate (TAF) in tablet formulations. The previous reported methods were costly, less efficient, utilized temperature and pH conditions for method development, making it more complex while this method utilizes lower quantity of mobile phase, an C18 column to improve efficiency, retention and reproducibility of the method without using the conditions of temperature and pH. The mixture of buffer (0.1% trifluoroacetic acid): ACN (65:35 v/v) was used as a mobile phase with isocratic elution. C18 column (Syncronis C18 250 x 4.6 mm) having particle size 5µm was used at a flow rate of 1mL/min. The suggested method described a linearity range of 30-80 µg/mL and the correlation coefficient equals to 0.997 that determines the linearity between the concentration and absorbance. The tailing factor and plate count were found to be 1.03 and 12110 under the acceptable limits.  According to ICH Q2 (R1) guidelines, all parameters were validated except LOD and LOQ. The drug was forcefully degraded by acid, alkali and oxidation.  Validated result showed that the method was precise, cheap, isocratic, definite, less time consuming, robust and was degraded within the acceptable limits. No interference was observed in the placebo and blank injections hence the method proved to be specific. The optimum RT (retention time) value was found to be 5.8 min. A simple, efficient and economic method was developed with no use of temperature and pH. The suggested method can be applied as a market analysis of TAF in the tablet form.
Stability Indicating HPTLC Method for Sofosbuvir and Daclatasvir in Combination
Authors: Damle Mrinalini , Pawar Nivedita
Published: November 2020

Direct acting antiviral agents represent the major advance in treatment of hepatitis C virus (HCV) infection. Daclatasvir with sofosbuvir that are co-administrated once per day oral dose has been reported to achieve a high rate of virological response in patients with HCV genotype 1, 2 or 3. So, the basic objective of a research involved development and validation of stability indicating HPTLC Method for simultaneous estimation of Sofosbuvir and Daclatasvir available in market in the form of combination tablet. Samples were applied on HPTLC aluminium plates precoated with silica gel 60 F254 (250μm thickness). Mobile phase consists of ethyl acetate: isopropanol in the ratio 9:1v/v. A good resolution was observed between peaks of both the drugs. The retention factor for Sofosbuvir is about 0.51 ±0.02. And for Daclatasvir is about 0.30 ± 0.02. Deuterium lamp as a source of radiation at the wavelength of 260 and 318 nm for analysis of Sofosbuvir and Daclatasvir, respectively. The proposed method was validated according to ICH guidelines and the results were acceptable for linearity and range, accuracy, precision, robustness, detection limit and quantitation limit. The calibration curves were linear over a wide range of 200-1000 ng/band (r2= 0.991) for Sofosbuvir and 45-225 ng/band (r2=0.990) for Daclatasvir. The limit of detection was found to be 21.17 ng/band and 4.38 ng/band for SOF and DAC and limit of quantitation was 64.18 ng/band and 13.28 ng/band for SOF and DAC respectively. During stress degradation study, it was observed that the Daclatasvir is degraded less in thermal and photolytic condition but more in basic hydrolysis condition. Sofosbuvir was found to be sensitive to all stress conditions except the fluorescent light. The suggested method was successfully applied for analysis of both drugs and excellent recovery results were obtained. Being simple, fast, robust, and economic, the method could be applied to the quality control and routine stability monitoring of Sofosbuvir and Daclatasvir.
Avances del diseño de una estrategia didáctica para la aplicación del modelo holístico de liderazgo policial – MHLP, desde la práctica docente en la Escuela de Carabineros, Provincia de Vélez
Authors: Villamizar Suárez Jesús Enrique , Riveros Guzmán Sandra Paola , Vacca Guerrero Diomayra Lorena
Published: November 2020

Este artículo es un avance de la investigación relacionada con la aplicación del Modelo Holístico de Liderazgo Policial (MHLP) de la Policía Nacional de Colombia (PONAL), en la Escuela de Carabineros Provincia de Vélez (ESVEL). En el caso de las escuelas de formación policial, aún no se han desarrollado procesos del MHLP. Por ello, ante esta necesidad y como un aporte a los docentes de la Escuela de Carabineros Provincia de Vélez, se está desarrollando el trabajo de investigación que antecede el presente artículo, cuya pregunta es ¿Cómo diseñar una estrategia didáctica para la aplicación del Modelo Holístico de Liderazgo Policial (MHLP), desde la práctica docente, en el Técnico Profesional en Servicio de Policía de la Escuela de Carabineros Provincia de Vélez “Mayor General Manuel José López Gómez”?, y cuyo objetivo general se enmarca en el diseño de la misma. Este estudio toma como base la investigación cualitativa, bajo un enfoque hermenéutico, apoyados en el estudio de caso. En el proceso de análisis de resultados de entrevistas, análisis documental y observaciones, se ha encontrado que los docentes desarrollan en sus clases aspectos del liderazgo, pero no cuentan con el conocimiento del MHLP. Asimismo, el plan de estudios no tiene una asignatura propia de liderazgo, estas situaciones permiten generar nuevas herramientas didácticas y pedagógicas que permitan la interiorización del Modelo Holístico en los futuros policiales.
Historiografía Chilena: Cuatro momentos de la educación
Authors: Alvarado González Jazmín
Published: November 2020

El presente artículo pretende generar un acercamiento general a las cuestiones historiográficas, al alrededor de la educación en Chile, iniciando desde el periodo de la independencia, posteriormente la dictadura, dando paso a la concertación  como una época de implementación de cambios propuestos por los militares, presentando importantes modificaciones hasta el 2005 y por último, los logros más destacados posteriores al 2005 en articulación con los acuerdos establecidos por la UNESCO 2000,  generando así una aproximación a la educación y los elementos que le han antecedido.
Educación de calidad y currículo: Una mirada desde las tendencias contemporáneas y el papel del docente
Authors: Portillo Wilches Jorge Camilo
Published: November 2020

El presente ensayo tiene como objetivo indagar acerca de las características más relevantes de las principales tendencias curriculares contemporáneas, además de dar una mirada al papel que debe desempeñar el docente en cada una de ellas, para que puedan contribuir de una manera efectiva a mejorar la calidad de la educación. Se inicia explicando la complejidad que subyace desde el mismo momento que se intenta definir lo que es la educación de calidad, posteriormente se plantean tres interrogantes: ¿Cuáles son las tendencias curriculares contemporáneas? ¿cuáles son sus características? y ¿qué papel desempeña el docente dentro de ellas? Luego de la revisión documental y en respuesta al primer interrogante se citan entre otras (1) la flexibilidad curricular, (2) el enfoque por competencias, (3) el enfoque por proyectos, (4) la incorporación de manifestaciones del curriculum oculto al curriculum en acción, y (5) la inclusión de las tecnologías de la información y la comunicación (TIC) y a continuación se detallan las definiciones, características y críticas de cada una de ellas. Se destaca que las tendencias estudiadas pueden complementarse, ya que tienen puntos en común como por ejemplo la necesidad de contextualizar y el llamado que se hace a los docentes para que abandonen los paradigmas tradicionales de enseñanza y la zona de confort.
método de investigación acción en el área educativa: Un ejercicio pertinente e inclusivo para los formadores del siglo XXI
Authors: Chicaiza Rey Monica , Martelo Yesenia , Blanquicett Narváez Ronal
Published: November 2020

El presente trabajo es un análisis del método de investigación de acción en relación con sus contribuciones al área de la educación. Comienza con la problematización de la práctica educativa realizada por los docentes, como principio fundamental para desarrollar un proceso educativo en contexto; es decir, coherente e inclusivo. Del mismo modo, la disertación finaliza describiendo las ventajas que tiene la investigación acción para mejorar la práctica educativa, así como la pertinencia de este método para la formación de niños y jóvenes con las habilidades necesarias para desempeñarse en la sociedad del siglo XXI, que está en constante cambio.
Convivencia escolar: Una manera de construir paz en la escuela a través de un modelo de justicia restaurativa
Authors: Sánchez Henao Mónica
Published: November 2020

La convivencia escolar como herramienta para que las personas puedan relacionarse de manera pacífica, hace uso de estrategias como la comunicación para la resolución de conflictos, donde el respeto como fuente de acción, permite una aceptación del otro tal y como es. El objetivo del presente artículo es presentar un modelo del proceso de justicia restaurativa aplicado a la escuela, donde se supere la concepción punitiva para dar paso a una visión restaurativa, que potencie la responsabilidad, la ética y los valores, y se logre promover la convivencia pacífica. La convivencia escolar implica cumplimiento de las normas que se acuerdan dentro del grupo, el trato cordial como una manera de fomentar las relaciones amistosas, y la participación dentro del grupo para así descubrir los talentos que cada uno puede aportar al desarrollo personal y social de los integrantes de la institución educativa. Este proceso requiere de acciones que permitan, no solo conciliar en los momentos de conflicto, sino reparar los daños en caso de trasgresiones, y propiciar la reflexión que se requiere para que los hechos no se repitan. Para ello la incorporación de la justicia restaurativa en la escuela, constituye un elemento que puede aportar pautas para los estudiantes, docentes, directivos, familiares, miembros de la comunidad, y también para el comité de convivencia escolar y el comité de convivencia municipal. Estas pautas abarcan la guía procesal de cada hecho, la valoración de las situaciones, el reconocimiento de las responsabilidades, la mediación como un espacio estructurado y dirigido para asistir a las partes involucradas, la socialización de los hechos, la restitución del daño causado, el monitoreo de los acuerdos, y la reconciliación con el otro, de manera que se pueda establecer una relación sin rencores.
competencias científicas y la multiculturalidad en la Colombia del siglo XXI
Authors: Coronado Milfred
Published: November 2020

El propósito de este documento es reflexionar sobre la temática alusiva a las competencias científicas y la multiculturalidad, en la Colombia del siglo XXI. A través de una revisión teórico conceptual y un acercamiento espacio-temporal se logra hacer un análisis del desarrollo de las competencias científicas en escenarios multiculturales en el país del café, del carbón y la esmeralda, en particular en la Región Caribe colombiana. El escrito propone el desarrollo de un currículo que observe la localidad pero que no se aleje de lo regional y nacional, como también que sea flexible, holístico, incluyente, entre otros. A través de él se generará experiencias significativas donde el estudiante inmerso en aulas multiculturales desarrolle también competencias científicas respetando los presaberes de estos y las investigaciones que realizan sobre su comunidad y contexto. Se hace alusión al pensamiento y a los conocimientos profesionales de los docentes porque son ellos en definitiva quienes orientan el proceso educativo y de la intencionalidad de ellos dependen el avance de los discentes en temas tan actuales como las competencias científicas y la multiculturalidad. Al final del documento se hacen algunas sugerencias dirigidas principalmente a la cualificación del maestro sobre la temática del artículo y la pertinencia de innovar en la simbiosis entre cultura y ciencia.
Analisis Deskriptif Kepuasan Konsumen Atas Kualitas Pelayanan Delta SPA & Health Club Palembang
Authors: Kamarudin Yos
Published: November 2020

Perkembangan dan peningkatan pelayanan Delta Spa & Health Club Palembang dari tahun ke tahun semakin menjadi perhatian masyarakat. Hal ini dapat dilihat dari ketatnya persaingan kualitas pelayanan di berbagai tempat-tempat Spa yang berada  di  Palembang.  Memberikan  layanan  yang baik  terhadap  semua  orang adalah tugas yang mulia, terlebih bagi mereka yang bekerja di sektor pelayanan.  Penelitian ini bertujuan untuk mengetahui analisis kualitas pelayanan terhadap kepuasan konsumen di Delta Spa & Health Club Palembang. Metode yang digunakan dalam penelitian ini adalah metode survei, pengumpulan data diperoleh dengan menggunakan   angket   berupa   pernyataan   tertulis   yang   diberikan   kepada responden untuk diisi dengan keadaan sebenarnya. Populasi dalam penelitian ini yaitu Konsumen Di Delta Spa & Health Club Palembang. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik insidental sampling sejumlah 65 orang responden..Analisis Citra digunakan untuk menganalisis data. Hasil penelitian ini menunjukkan bahwa kualitas pelayanan  terhadap kepuasan konsumen di Delta Spa & Health Club Palembang  sebagian besar mempunyai sikap Puas sebesar 43,08 %, sikap tidak puas   sebesar 26,15 %, Sangat Tidak Puas 20,0 % dan Sangat  Puas  10,77  %,  dapat  disimpulkan    kualitas  pelayanan     terhadap kepuasan konsumen di Delta Spa & Health Club Palembang adalah Puas.
Pengaruh Kepuasan Kerja Terhadap Kinerja Individual dengan Self Efficacy sebagai Variabel Intervening
Authors: Choirunissa Alfania , Prayekti Prayekti , Septyarini Epsilandri
Published: November 2020

This study aims to determine the effect of job satisfaction on individual performance with self-efficacy as an intervening variable for employees of PT Nusantara Surya Sakti Yogyakarta.

This type of research used in this research is descriptive quantitative. The population used is all employees of PT Nusantara Surya Sakti Yogyakarta as many as 55 employees. The sample in this study were all employees of PT Nusantara Surya Sakti Yogyakarta, as many as 55 employees. The sampling technique used was total sampling with data collection methods using a questionnaire. The data analysis technique in this study used simple linear regression.

Based on the results of this study, job satisfaction has no significant positive effect on individual performance. Job satisfaction has significant positive effect on self efficacy and self efficacy has significant positive on individual performance. In this study, self efficacy as an intervening variable has a significant positive effect on job satisfaction on individual performance.

 Keywords : Job Satisfaction, Individual Performance, and Self Efficacy
ELEKTRONİK KÜLTÜR ORTAMINDA NEOLOJİZM
Authors: ÇELİKTEN Esra , ÇELİKTEN Hakan
Published: November 2020

Yüzyıllardan beri insanlar arasında anlaşmayı sağlayan, kültür değerlerini nesilden nesle taşıyan, her bir süreçte kendini yenileyen ve geliştiren, kendine ait bir sistemi olan yapıya dil denir. Bu sistemin kendi içinde kuralları olsa da dışardan etkiye de her zaman açıktır. Dilin bu dinamik yapısı onu iyileştiren ve geliştiren tarafını oluştursa da bazen bu yeni yapılanma dilin zararına da olabilmektedir. Dil içinde olmayan ancak çeşitli ihtiyaçlardan veya çeşitli sebeplerden ortaya çıkan yeni kavramların oluşmasını sağlayan neolojizm, bu türden bir yapıdır. Teknolojinin gelişmesiyle birlikte coğrafyanın bir öneminin kalmaması durumu, elektronik kültür ortamında yeni yapıların ortaya çıkmasına sebep olmuştur. Dilimize çoğunlukla elektronik kültür ortamıyla yayılan yabancı kelimeler zaman içinde birtakım değişmeler göstermiştir. Buna göre zamanla yabancı kökenli sözcüklere Türkçeymiş gibi muamele edilmiş, bu kelimelere Türkçe ekler veya fiiller getirilmiştir. Bu çalışmanın amacı; elektronik kültür ortamında yaşanan bu yeni neolojizmi ele almak, yabancı kelimelere gelen Türkçe ekleri ve fiilleri tespit etmeye çalışmaktır.
Bevezetés a likelihood kriminalisztikai alkalmazásához
Authors: Orbán József
Published: November 2020

Building on practical examples, the author provides an overview of the concept of likelihood in forensic sciences.
A Safe Harbor határozat érvénytelenítésének hatása az európai adatvédelmi gyakorlatra
Authors: Schubauer Petra
Published: November 2020

The author provides an overview of the potential effect of the European Union’s Court of Justice’s decision in Maximillian Schrems contra Data Protection Commissioner on privacy.
A vérnyomelemzés mint a helyszínelés innovatív eszköze
Authors: Petrétei Dávid
Published: November 2020

The author provides an overview of the possibilities of blood pressure analysis and future development opportunities in Hungary.