bluuebunny/crossref_metadata_2025 huggingface dataset:
Searching for Alternative Development of Economy and Marketing Role of Higher Economics Education in Russia
Authors: Belskikh I. E. , Golovina Yu. E.
Published: May 2024

Economy of the country and regions today find themselves in a complicated situation of choosing alternative ways of development. Declining international influence leads to analysis and substantiation of new ways of development. Marketing as a centre of coordination for region sustainable development is becoming a supporting structure for the growing appeal on home market. Higher economics education and its agents, i. e. Russian universities of economics will bear high responsibility for searching and substantiation of alternatives ways of working on markets. On the basis of expert assessment and comparative analysis of economics and other regional universities (pedagogical, technical, classical) competitive advantages of specialized higher education institutions in working with mass media were demonstrated. Managerial features, professional orientation of education and training programs, economic links with regional enterprises can highlight these advantages. Rising requirements of branch regulators to media activity of universities result in chaotization of information flows and increase in their impact on regional positioning. Therefore, we can observe an antagonistic dualism between harsh reality and magic virtual pictures. The authors put forward a logical scheme for resolving this problem, relying on synthesis of institutionalism, cluster approach (according to M. Porter) and conventional territorial and industrial marketing.
Beyond the Genome: Deciphering the Role of MALAT1 in Breast Cancer Progression
Authors: Hussain Md Sadique , Agrawal Mohit , Shaikh Nusratbanu K. , Saraswat Nikita , Bahl Gurusha , Bhat Mudasir Maqbool , Khurana Navneet , Bisht Ajay Singh , Tufail Muhammad , Kumar Rajesh
Published: May 2024

:

The MALAT1, a huge non-coding RNA, recently came to light as a multifaceted regulator
in the intricate landscape of breast cancer (BC) progression. This review explores the multifaceted
functions and molecular interactions of MALAT1, shedding light on its profound implications
for understanding BC pathogenesis and advancing therapeutic strategies. The article commences
by acknowledging the global impact of BC and the pressing need for insights into its
molecular underpinnings. It is stated that the core lncRNA MALAT1 has a range of roles in both
healthy and diseased cell functions. The core of this review unravels MALAT1's multifaceted role
in BC progression, elucidating its participation in critical processes like resistance, invasion, relocation,
and proliferating cells to therapy. It explores the intricate mechanisms through which
MALAT1 modulates gene expression, interacts with other molecules, and influences signalling
pathways. Furthermore, the paper emphasizes MALAT1's clinical significance as a possible prognostic
and diagnostic biomarker. Concluding on a forward-looking note, the review highlights the
broader implications of MALAT1 in BC biology, such as its connections to therapy resistance and
metastasis. It underscores the significance of deeper investigations into these intricate molecular
interactions to pave the way for precision medicine approaches. This review highlights the pivotal
role of MALAT1 in BC progression by deciphering its multifaceted functions beyond the genome,
offering profound insights into its implications for disease understanding and the potential for targeted
therapeutic interventions.
Gut Microbiota Modulation by Selenium and Zinc Enrichment Postbiotic on Dysbiosis Associated with Hypertension
Authors: Dinu Laura-Dorina , Gatea Florentina , Matei Florentina , Banciu Cristian , Vamanu Emanuel
Published: May 2024

Background:

Targeting gut dysbiosis to treat chronic diseases or to alleviate the symptoms
is a new direction for medical adjuvant therapies. Recently, postbiotics have received considerable
attention as they are non-viable probiotic preparations that confer various health benefits to
the host without the safety problems associated with using live microbial cells.

Objective:

The aim of the study is to obtain selenium (Se) and zinc (Zn) enriched Saccharomyces
boulardii postbiotic biomass and to analyze its modulation effect because these minerals play an
important role in reducing gut dysbiosis linked to cardiovascular (CV) diseases.

Method:

The effect of the S. boulardii and Se/Zn enriched yeast postbiotics on CV microbial fingerprint
was studied in vitro using the gastrointestinal system (GIS 1) and analyzed by microbiological,
chemical, and qPCR methods.

Result:

There was a 2.2 log CFU/mL increase in the total bacterial load after SeZn postbiotic treatment
and in the qPCR counts of Firmicutes phyla for both treatments. Beneficial taxa, Bifidobacterium
spp. and Lactobacillus spp., as well as Bacteroides spp. were up to 1.5 log higher after mineral-
enriched postbiotic application, while the acetic acid level increased.

Conclusion:

These preliminary studies highlight the therapeutic potential of using Se/Zn enriched
yeast postbiotics as adjuvants for clinical treatments of CV diseases.
The Role of Stem Cell Therapies in the Treatment of Neurodegenerative Diseases
Authors: Jayaprakash Bindhu , Savira Maya , Mahmood Ammar Abdul Razzak , Prasanna Muthu
Published: May 2024

Cellular replacement therapy and genetic transfer in injured brains provide new pathways
for treating human neurological illnesses. Current progress in the field focuses on the production
of neurons and glial cells from many types of stem cells, such as embryonic, induced
pluripotent, mesenchymal, and neural stem cells. This has led to a significant increase in research
on brain transplantation treatments. Extended neurodegeneration results in the progressive decline
of certain neuronal subtypes or whole neuronal cells. An analysis of the progress made in induced
pluripotent and mesenchymal stem cells reveals their significant promise in disease modeling, regeneration,
and medication screening. The requirement for stem cells in neurodegenerative disease
studies has been crucial in recent years. Stem cells provide the potential for replacing impaired
neurons, comprehending disease needs modeling, and creating efficient treatments, but
they have many challenges in culturing and acceptability to the host immune cells. The need to
use their potential in discovering novel therapies for diseases such as Alzheimer's, Parkinson's,
and amyotrophic lateral sclerosis leads to promising therapy. This review examines the function
of stem cells in the pathogenesis and treatment of Huntington's disease, Parkinson's disease,
Alzheimer's disease, and multiple sclerosis. This review further examines hurdles such as immunological
reactions and delivery systems intending to overcome these problems. This article offers a
detailed viewpoint on the use of stem cell-based nanotherapies as revolutionary treatments for
various neurological illnesses.
PDLIM1 Inhibits Chemoresistance by Blocking DNA Damage Repair in Gastric Cancer
Authors: Chen Yuli , Yang Xin , Li Qiang
Published: May 2024

Objective:

Current cisplatin (CDDP) resistance remains a major challenge in the treatment
of advanced gastric cancer. To address the issue of drug resistance, we explored the regulatory
functions of PDZ and LIM structural domain protein 1 (PDLIM1) in CDDP chemotherapy for
gastric cancer.

Methods:

In this study, we analyzed PDLIM1 expression and prognosis using bioinformatics on
publicly available data. PDLIM1 expression in a gastric mucosal epithelial cell line (GSE-1), CDDP-
sensitive (SGC7901, BGC823) and CDDP-resistant gastric cancer cells was detected by RTqPCR
and Western blotting. Cell proliferative capacity was assessed by knockdown of PDLIM1
and overexpression of PDLIM1 in cells administered in combination with cisplatin, and apoptotic
levels were measured by CCK-8 and colony formation assay and by flow cytometry. Expression
of breast cancer susceptibility gene 1 (BRCA1) and γH2AX was determined by Western blotting
or immunofluorescence staining.

Results:

Downregulation of PDLIM1 was found in tumor tissues and cells, which was associated
with poor clinical outcomes. Knockdown of PDLIM1 enhanced proliferation and attenuated apoptosis
in gastric cancer cells. In addition, the therapeutic effects of CDDP on proliferation, apoptosis,
and DNA damage repair were attenuated by PDLIM1 deletion.PDLIM1 expression was downregulated
in CDDP-resistant tumor cells. Overexpression of PDLIM1 overcomes CDDP resistance
in tumor cells as BRCA1 expression decreases and γH2AX expression increases.

Conclusion:

Our findings demonstrate that PDLIM1 enables to alleviate gastric cancer progression
and resistance to cisplatin via impeding DNA damage repair.
Gait Characteristics over the Six-minute Walk Test in Older Women of a Specific Portuguese Community: A Cross-Sectional Study
Authors: Silva Jullyanne , Atalaia Tiago , Martins Rodrigo , Abrantes Joao , Aleixo Pedro
Published: May 2024

Introduction and Objective:

There is limited research on the changes that can occur in
the gait biomechanical parameters of older adults over long-distance walking. Thus, this study
aimed to evaluate the gait characteristics of older women of a specific Portuguese community
over the six-minute walk test (6MWT) along with gait spatial and temporal parameters and angular
kinematics of the lower limb joints.

Materials and Methods:

Twenty-six older women voluntarily participated. Each woman performed
the 6MWT, and during this, their spatial and temporal parameters were collected through
plantar pressure data (100Hz) and angular kinematics through an inertial sensor system (100Hz).
The 6MWT was divided into four intervals, and the Friedman test was used to compare them. The
median age of the women was calculated, and the Mann-Whitney test was used to compare women
above and below the median age value.

Results:

An increase in gait speed, stance phase, and double stance phase along the intervals was
observed, as well as larger angular displacements of the hip, knee, and ankle (p<0.05). Women below
or above the median age value also yielded these behaviours. Gait speed, cadence, stride
length, and step length were higher in women below the median age value, while stride and step
duration were lower (p<0.05).

Conclusion:

Older women yielded changes in gait spatial and temporal parameters along the
6MWT, as well as larger angular displacements of the lower limb joints. Older women (compared
to younger ones) yielded lower gait speed, cadence, stride length, and step length, higher stance
and double stance phases, and shorter angular displacements of the lower limb joints.
Review of Clinical Considerations in the Management of Adolescents with ADHD During Ramadan
Authors: Khan Faraz , Mohiuddin Sarah
Published: May 2024

Background:

Fasting in Ramadan, a holy month in Islam, is considered a
religious obligation to Muslims after puberty. Fasting during Ramadan entails
abstinence from consuming food and liquids, as well as abstaining from other
activities, including smoking and sexual activity, from dawn until sunset. Literature
exists regarding the management of multiple medical conditions impacted by the
month of fasting; however, limited literature exists to guide the management of
Attention-Deficit/Hyperactivity Disorder (ADHD) during Ramadan.

Methods:

This systematic review employed a PUBMED search which was
conducted using keywords ((ADHD) AND (Muslims)) OR ((ADHD) AND
(FASTING)) OR ((ADHD) AND (RAMADAN)) OR ((RAMADAN) AND
(MANAGEMENT)) and search strategies to find existing literature on ADHD
management during Ramadan or while fasting.

Results:

Eight hundred and sixty-one results were obtained. Of these, full texts of
clinical trials, systematic reviews, reviews, randomized control trials, and metaanalyses
resulted in 303 results that were screened by title or abstract for relevance to
the topic. The duplicate articles were removed. Eighty-nine results were incorporated
into this paper, including full articles, book excerpts, and online articles.

Discussion:

Muslim adolescents may face challenges with academic and social
functioning as they navigate psychosocial changes in the context of Ramadan.
ADHD management options should be discussed with individuals who are planning
to fast. Pharmacologic management options include continuing on the current
regimen, dose adjustment to mitigate side effect exacerbation, a change in medication
class, or a change in medication formulation. For severe cases or cases with comorbid
conditions, continued fasting may not be recommended. In these cases, the patient
should attempt to seek counsel with their community’s religious scholar in
collaboration with their medication provider. Ultimately, there are limitations in the
available data, and there is a need for further investigation into the impacts of fasting
during Ramadan on individuals with ADHD and the effectiveness of interventions to
promote treatment adherence.
Production of Valuable Methanol from Hazardous Methane: Advances in the Catalysis
Authors: Datta Sayanti , Kumar Seth Dipravath
Published: May 2024

Being a greenhouse gas, methane is a threat to biodiversity. Hence, the utilization of
methane by converting it into a valuable chemical like methanol is one of the most promising reactions.
To solve that problem, a large number of studies have been performed on methane-tomethanol
conversion (MTM process). Still, to date, the production of methanol from methane on
an industry scale is a crucial challenge. After a thorough study, in this review article, only those
reported methods, which produce a satisfactory yield of methanol using a large variety of catalysts
like natural, heterogeneous, non-thermal plasma, nanoparticles fixed in solid bed, etc., have
been briefly discussed. To investigate minutely, the reason behind the inefficiency of each type
of catalyst in producing methanol on a large scale has been analyzed, and a comparison among
the activities of different catalysts has been made. Herein, catalysts with comparatively better efficiency
under ambient temperature and pressure have also been highlighted. With the hope of
producing methanol on a large scale, some basic concepts of future planning strategies for designing
more suitable reaction systems are also proposed in this study
The Synergistic Enhancement of Anti-Metabolic Diseases Function of
Morus alba with the Combination of Cha (Camellia sinensis)
Authors: Sato Shinji , Konishi Tetsuya
Published: May 2024

Background:

Functional foods play an important role in the prevention and ameliora-tion of metabolic syndromes leading to type 2 diabetes. Plant resources that have anti-metabolic syndromes activity, such as Morus alba L. and Cha [Camellia sinensis L.], have been used in functional foods against diabetes. Since Morus and Cha have different mechanisms of action against metabolic syndromes, such as prevention of sugar uptake and lipidosis, respectively, and the combination of both resources will be a reliable approach for developing more efficient functional food against type 2 diabetes because certain synergism is expected in their functions.

Methods:

Male Wister Rats were fed the high fat-high sucrose [HFHS] diet for 12 weeks, with and without supplementation of Morus and Cha alone and their combination, and the effect of their supplementation on the markers of the metabolic syndrome such as obesity, lipidosis, and fatty liver formation, were examined.

Results:

Several metabolic syndrome markers, including body weight gain, lipid deposit, and fatty liver formation, were more significantly prevented by the diet supplemented with Morus and Cha combination compared to Morus or Cha given separately .

Conclusion:

Appropriate formulation of food resources with different functional mechanisms is a promising strategy for developing effective dietary treatment of type 2 diabetes that is a typical Mibyou.
Dose-Response Relationship Between Physical Activity and the Morbidity and Mortality of Cardiovascular Disease Among Individuals With Diabetes: Meta-Analysis of Prospective Cohort Studies
Authors: Chen Yang , Jin Xingsheng , Chen Guochong , Wang Ru , Tian Haili
Published: May 2024

Background

Diabetes, a chronic condition affecting various organs, is frequently associated with abnormal lipid metabolism, notably increased cholesterol and triglyceride levels. These lipid abnormalities are closely linked to the development and advancement of cardiovascular disease (CVD). Although regular physical activity (PA) has consistently shown benefits in reducing CVD risk in the general population, its precise influence on CVD risk among patients with diabetes remains uncertain, particularly regarding dose-response relationships.

Objective

This study aimed to summarize the evidence from prospective studies on the association between PA and CVD morbidity and mortality in individuals with diabetes and explore the optimal levels for public health recommendation.

Methods

We systematically reviewed prospective cohort studies in PubMed, Embase, and Web of Science up to December 2022, with inclusion criteria specifying the studies published in English and included adult participants diagnosed with diabetes. A random effects model was used to pool the relative risk (RR) with the corresponding 95% CI comparing the highest with the lowest PA categories in each study for qualitative evaluation. In addition, linear and spline regression analyses were used to estimate dose-response associations.

Results

The meta-analysis included 12 prospective cohort studies, involving a total of 109,820 participants with diabetes. The combined results revealed that higher levels of PA were associated with a reduced risk of CVD. The RR of CVD for the highest compared with the lowest PA category was 0.62 (95% CI 0.51-0.73). In addition, there were 4 studies describing leisure-time PA, and the pooled RR was 0.68 (95% CI 0.52-0.83) for the highest versus the lowest activity. The linear regression model revealed that each 10 MET (metabolic equivalent of task)-hours per week of incrementally higher PA was associated with a 19% (95% CI 11.6-25.7) and a 6.9% (95% CI 4.5-9.3) reduction in CVD morbidity and mortality. Additionally, spline regression curves showed nonlinear relationships between PA levels and the risk of CVD and CVD mortality (both Pnonlinearity<.001), with a limited reduction in CVD risk and some further reduction in CVD mortality above 20 MET-hours per week of PA levels.

Conclusions

For patients with diabetes, especially type 2 diabetes, there was a dose-response relationship between increased PA and reduced risk of CVD morbidity and mortality. The observed PA threshold is consistent with the recommended level for the general population. Gradually moving from inactivity to a guideline-recommended PA level could therefore significantly reduce the burden of CVD in patients with diabetes.
Cardiovascular Comorbidities in COVID-19: Comprehensive Analysis of Key Topics
Authors: Markovič Rene , Ternar Luka , Trstenjak Tim , Marhl Marko , Grubelnik Vladimir
Published: May 2024

Background

The interrelation between COVID-19 and various cardiovascular and metabolic disorders has been a critical area of study. There is a growing need to understand how comorbidities such as cardiovascular diseases (CVDs) and metabolic disorders affect the risk and severity of COVID-19.

Objective

The objective of this study is to systematically analyze the association between COVID-19 and cardiovascular and metabolic disorders. The focus is on comorbidity, examining the roles of CVDs such as embolism, thrombosis, hypertension, and heart failure, as well as metabolic disorders such as disorders of glucose and iron metabolism.

Methods

Our study involved a systematic search in PubMed for literature published from 2000 to 2022. We established 2 databases: one for COVID-19–related articles and another for CVD-related articles, ensuring all were peer-reviewed. In terms of data analysis, statistical methods were applied to compare the frequency and relevance of MeSH (Medical Subject Headings) terms between the 2 databases. This involved analyzing the differences and ratios in the usage of these terms and employing statistical tests to determine their significance in relation to key CVDs within the COVID-19 research context.

Results

The study revealed that “Cardiovascular Diseases” and “Nutritional and Metabolic Diseases” were highly relevant as level 1 Medical Subject Headings descriptors in COVID-19 comorbidity research. Detailed analysis at level 2 and level 3 showed “Vascular Disease” and “Heart Disease” as prominent descriptors under CVDs. Significantly, “Glucose Metabolism Disorders” were frequently associated with COVID-19 comorbidities such as embolism, thrombosis, and heart failure. Furthermore, iron deficiency (ID) was notably different in its occurrence between COVID-19 and CVD articles, underlining its significance in the context of COVID-19 comorbidities. Statistical analysis underscored these differences, highlighting the importance of both glucose and iron metabolism disorders in COVID-19 research.

Conclusions

This work lays the foundation for future research that utilizes a knowledge-based approach to elucidate the intricate relationships between these conditions, aiming to develop more effective health care strategies and interventions in the face of ongoing pandemic challenges.
Training Service Users in the Use of Telehealth: Scoping Review
Authors: Galvin Emer , Desselle Shane , Gavin Blánaid , McNicholas Fiona , Cullinan Shane , Hayden John
Published: May 2024

Background

The use of telehealth has rapidly increased, yet some populations may be disproportionally excluded from accessing and using this modality of care. Training service users in telehealth may increase accessibility for certain groups. The extent and nature of these training activities have not been explored.

Objective

The objective of this scoping review is to identify and describe activities for training service users in the use of telehealth.

Methods

Five databases (MEDLINE [via PubMed], Embase, CINAHL, PsycINFO, and Web of Science) were searched in June 2023. Studies that described activities to train service users in the use of synchronous telehealth consultations were eligible for inclusion. Studies that focused on health care professional education were excluded. Papers were limited to those published in the English language. The review followed the Joanna Briggs Institute guidelines for scoping reviews and was reported in line with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. Titles and abstracts were screened by 1 reviewer (EG). Full texts were screened by 2 reviewers (EG and JH or SC). Data extraction was guided by the research question.

Results

The search identified 8087 unique publications. In total, 13 studies met the inclusion criteria. Telehealth training was commonly described as once-off preparatory phone calls to service users before a telehealth visit, facilitated primarily by student volunteers, and accompanied by written instructions. The training content included guidance on how to download and install software, troubleshoot technical issues, and adjust device settings. Older adults were the most common target population for the training. All but 1 of the studies were conducted during the COVID-19 pandemic. Overall, training was feasible and well-received by service users, and studies mostly reported increased rates of video visits following training. There was limited and mixed evidence that training improved participants’ competency with telehealth.

Conclusions

The review mapped the literature on training activities for service users in telehealth. The common features of telehealth training for service users included once-off preparatory phone calls on the technical elements of telehealth, targeted at older adults. Key issues for consideration include the need for co-designed training and improving the broader digital skills of service users. There is a need for further studies to evaluate the outcomes of telehealth training activities in geographically diverse areas.
Influence of TikTok on Body Satisfaction Among Generation Z in Indonesia: Mixed Methods Approach
Authors: Ariana Hanifa , Almuhtadi Ikmal , Natania Nikita Jacey , Handayani Putu Wuri , Bressan Stéphane , Larasati Pramitha Dwi
Published: May 2024

Background

As social media platforms gain popularity, their usage is increasingly associated with cyberbullying and body shaming, causing devastating effects.

Objective

This study aims to investigate the impact of social media on Generation Z users’ body image satisfaction. More specifically, it examines the impact of TikTok on body image satisfaction among TikTok users aged between 17 years and 26 years in Indonesia.

Methods

The methodology used mixed-method approaches. Quantitative data were obtained from 507 responses to a questionnaire and analyzed using covariance-based structural equation modeling. Qualitative data were obtained from the interviews of 32 respondents and analyzed through content analysis.

Results

This study reveals that upward appearance comparison is influenced by video-based activity and appearance motivation. Conversely, thin-ideal internalization is influenced by appearance motivation and social media literacy. Upward appearance comparisons and thin-ideal internalization comparisons detrimentally impact users’ body image satisfaction.

Conclusions

The results of this study are expected to provide valuable insights for social media providers, regulators, and educators in their endeavors to establish a positive and healthy social media environment for users.
Mobile App for Patients With Chronic Obstructive Pulmonary Diseases During Home-Based Exercise Care: Usability Study (Preprint)
Authors: Chien Shih-Ying
Published: May 2024

BACKGROUND

Digital health tools have demonstrated promise in the treatment and self-management of chronic diseases while also serving as an important means for reducing the workload of health care professionals (HCPs) and enhancing the quality of care. However, these tools often merely undergo large-scale testing or enter the market without undergoing rigorous user experience analysis in the early stages of their development, leading to frequent instances of low use or failure.

OBJECTIVE

This study aims to assess the usability of and satisfaction with a mobile app designed for the clinical monitoring of patients with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation at home.

METHODS

This study used a mixed methods approach involving two key stakeholders—patients with chronic obstructive pulmonary disease and HCPs—across three phases: (1) mobile app mock-up design, (2) usability testing, and (3) satisfaction evaluation. Using convenience sampling, participants were grouped as HCPs (n=12) and patients (n=18). Each received a tablet with mock-ups for usability testing through interviews, with audio recordings transcribed and analyzed anonymously in NVivo12.0, focusing on mock-up features and usability insights. Task difficulty was rated from 1 (very easy) to 5 (very difficult), with noncompletion deemed a critical error. Usability satisfaction was measured on a 5-point Likert scale from 1 (strongly disagree) to 5 (strongly agree).

RESULTS

The research indicated a notable difference in app usability perceptions: 66% (8/12) of HCPs found tasks “very easy,” compared to only 22% (4/18) of patients. Despite this, no participant made critical errors or withdrew, and satisfaction was high. HCPs completed tasks in about 20 minutes, while patients took 30. Older adults faced challenges with touch screens and scroll menus, suggesting the need for intuitive design aids like auditory support and visual health progress indicators, such as graphs. HCPs noted potential data delays affecting service, while non–native-speaking caregivers faced interpretation challenges. A secure pairing system for privacy in teleconsultations proved difficult for older users; a simpler icon-based system is recommended. This study highlights the need to consider stakeholder abilities in medical app design to enhance function implementation.

CONCLUSIONS

Most HCPs (11/12, 91%) found the app intuitive, though they recommended adding icons to show patient progress to support clinical decisions. In contrast, 62% (11/18) of patients struggled with tablet navigation, especially with connectivity features. To ensure equitable access, the design should accommodate older users with diverse abilities. Despite challenges, both groups reported high satisfaction, with patients expressing a willingness to learn and recommending the app. These positive usability evaluations suggest that, with design improvements, such apps could see increased use in home-based care.
Follow up of patients with chronic pain using an app with a support center: unicenter prospective study (Preprint)
Authors: Gómez-González Marta Antonia , De la Cruz Sabido Javier , Sánchez Corral Carlos , Lechuga Carrasco Beatriz , López-Vicente Marta , Olivares Granados Gonzalo
Published: May 2024

BACKGROUND

Lower back pain is one of the most prevalent diseases, and should be treated with a multidisciplinary approach, being a possibility the use of spinal cord stimulation. These patients need a close follow up that cannot always be guaranteed, with new technologies helping in that regard. We designed a remote follow up system based on a mobile phone app for the patient, a web for professionals, and a remote support center.

OBJECTIVE

To evaluate patient adherence to follow up using a system with phone app and a remote support center.

METHODS

After reviewing the literature and approval in a multidisciplinary committee, a group of experts designed a follow up system based on a mobile phone app, a web for professionals and a remote support center. The system was designed with medical professionals involved, sending validated scales to obtain patients’ clinical information through every phase of the implantation (pre-treatment phase, trial phase and implantation phase). Data was collected prospectively from annuary 2020 to august 2023, considering total surveys sent and surveys answered to, in addition to reminders sent.

RESULTS

A total of 64 patients were included (40 female, 62’5%). At the end of the study, 19 patients were in the pre-treatment phase (29’7%), 8 patients achieved the trial phase (12’5%) and 37 achieved the implantation phase (57’8%). The follow up time was 15’30 +/- 9’43 months (mean +/- SD). A total of 1574 surveys were sent, with a total of 488 sms and 53 calls to remind the patients to answer the surveys. Adherence rates decreased from 94’53% in pre-treatment phase to 65’68% in implantation phase, being the global adherence to the use of the app 87’37%. In the ANOVA analysis, the adherence was proved better the earlier phase the patient was in (p>0’001).

CONCLUSIONS

Our remote follow up system with a remote support center provides better adherence to follow up, even if the adherence tends to decrease over time. More studies are needed to correlate app adherence with pain control.
Leveraging Dual Usability Methods to Evaluate Clinical Decision Support among Traumatic Brain Injury Patients (Preprint)
Authors: Rizvi Rubina F. , Faisal Sameen , Sussman Mark , Mendlick Patricia , Brown Sam , Lindemann Elizabeth , Keiser Jeremy , Kalra Manish , Switzer Sean , Melton-Meaux Genevieve B. , Tignanelli Christopher J.
Published: May 2024

BACKGROUND

Traumatic brain injury patients (TBI) are at increased risk of developing venous thromboembolism (VTE). Clinical decision support systems (CDSSs) may improve the utilization of VTE prophylaxis protocols yet suffer from poor compliance among end-users due to a lack of user-centered design.

OBJECTIVE

The objective of this research work was to improve the content, design, and workflow integration of a TBI-CDSS based on feedback from the experts and end-users.

METHODS

The CDSS was evaluated leveraging a dual usability approach. A set of usability experts (N=3) and trauma providers (N=5) performed the heuristic evaluation (HE) and end-user testing (E-UT). Data was collected through triangulation of methods and analyzed using qualitative (thematic) and quantitative (descriptive) analyses.

RESULTS

We identified 145 total issues across both methods with 66 being unique i.e., 17 issues found by HE, 43 by E-UT, and 6 common ones. Thematic analysis was conducted on the unique issues (66) and was assigned to themes and subsequent sub-themes. We identified 13 unique themes. The three most identified themes were lack of supporting evidence (17 issues, representing 26% of the 66 issues), operational barriers arising from the test environment (11,17%), formatting inconsistencies, and lack of following standards (8, 12 %). The system's usability scale survey (SUS) score was 77.5 (std dev ±16) interpreted as an acceptable/good usability range.

CONCLUSIONS

Combining expert and end-user-driven usability evaluation methods led to the identification of a more comprehensive list of issues. This can facilitate the optimization of the TBI-CDSS, resulting in improved usability and care management.

CLINICALTRIAL

This component of the project is not a clinical trial. The study protocol was submitted to the University of Minnesota Institutional Review Board and given the determination of “Exempt” as secondary research for which consent is not required. The mixed methods investigation was given the determination of “Not Human Research” as a quality improvement activity.
Improving Accessibility for Work Opportunities for Autistic Adults: A Study Protocol
for an End-to-End Supported Workplace Program (Preprint)
Authors: Guastella Adam John , Hankin Lorna , Stratton Elizabeth , Glozier Nick , Pellicano Elizabeth , Gibbs Vicki
Published: May 2024

BACKGROUND

Autistic adults have a strong desire and need for employment that matches their strengths, skills, and interests. Yet, they are more likely to be un- or under-employed than their neurotypical peers. Facilitators to successful employment include positive attitudes towards and awareness of autism in the workplace, and provision of adequate support and accommodations, including mental health support. Despite previous workplace programs identifying the need for adapted recruitment and interviewing processes, awareness training, and ongoing employee support, there are no programs that specifically provide these supports and adaptations for autistic employees.

OBJECTIVE

In this study protocol, we describe a framework for a new end-to-end supported workplace program for autistic adults that encompasses eight key areas to promote inclusive workplaces and improve recruitment and retention of autistic employees.

METHODS

Autistic candidates (n = 15) will complete two workplace skills training sessions at the University of Sydney’s Brain and Mind Centre, before attending a tailored interview, onboarding session and paid 12-week placement at consulting firm Ernst and Young (EY). EY managers and colleagues (n = 30) will complete a half-day awareness and inclusion training program before supporting the autistic adults through their 12-week placements. Tailored mental health support will also be provided.

RESULTS

Data collection for this study was completed in February 2022. The data analysis is still in progress. The results are of the study are expected to be available by the end of 2024.

CONCLUSIONS

This study holds the potential to enhance the recruitment and retention of autistic adults, as well as their overall experience in the workplace.
HEIR APPARENT PREPAREDNESS AND SELECTED FAMILY BUSINESS SUSTAINABILITY IN LAGOS STATE NIGERIA
Authors: Olayemi Olufemi Olabode , Gbadamosi Taofeek Olalekan
Published: May 2024

Family-owned businesses are extremely important to Nigeria's economy, creating jobs, generating income, and helping the country's GDP increase. However, the Heir Apparent's readiness to take on leadership responsibilities poses a threat to their sustainability. Myriads of research on family businesses and their sustainability exist, but little of it has looked at heir apparent as a factor of sustainability. By analyzing the relationship between heir apparent preparedness and the sustainability of selected family-owned firms in Lagos State, Nigeria, this study seeks to bridge the gap in literature. Drawing on a deductive methodology, the study employs a cross-sectional survey to gather quantitative data. Responses from 388 family-owned enterprises were obtained using a questionnaire. Data were analyzed by applying SPSS package, version 25. The findings reveal significant positive relationships between Heir Apparent Level of Education, Heir Apparent Experience, and Quality of Mentorship Received by Heir Apparent, and their joint effect with family business sustainability. It was thereby concluded that heir apparent level of preparedness impacts the sustainability of family businesses in Lagos State. The study recommends prioritizing formal education, providing diverse experiential learning opportunities, and establishing strong mentorship programs to enhance family business sustainability.
TENETS OF THE SLOW FOOD MOVEMENT AS MOTIVATION FOR TOURISTS TO VISIT RURAL TOURIST HOUSEHOLDS IN SERBIA
Authors: Lunić Darija , Surla Tamara , Pivac Tatjana , Micera Roberto
Published: May 2024

Local cuisine is one of the foundations for how Serbian rural communities are presented to tourists. The desire for regional cuisine has recently increased, which has created opportunities for the promotion of regional and, most importantly, traditional production. The changing behaviours of travellers, who are becoming more conscious of the value of authenticity and quality when travelling, offer opportunities for rural areas to thrive while also creating a new horizon for tourism centered on the discovery of traditional cuisine and rural communities. This kind of travel can be compared to slow travel, which was developed in conjunction with the Slow Food movement. The Slow Food movement is a political and cultural movement with the goal of opposing the industrialisation of food production, promoting locally made, high-quality, sustainable food, and making a significant contribution to rural areas. Three guiding principles – good, clean, and fair – define what food should be and form the foundation of this movement. The major objective of this paper is to present the driving elements that have the biggest impact on tourists’ enthusiasm to visit rural tourist houses in Serbia. The research also seeks to determine how much the respondents’ desire to return to Serbia’s rural tourist households is influenced by motivating factors.
El papel de la isoforma M2 de la piruvato cinasa en el metabolismo del cáncer
Authors: Ponce-Tecla Antonio , Ramírez-Silva Leticia , Hernández-Alcántara Gloria
Published: May 2024

En la oncogénesis los distintos tipos de cáncer presentan alteraciones en el funcionamiento de sus diversas proteínas reguladoras, así como las proteínas que normalmente no están relacionadas con el control del ciclo celular. Es el caso de la piruvato cinasa en su isoforma M2 (PKM2), que es una enzima clave en la regulación del metabolismo energético en la vía glucolítica. La PKM2 está involucrada principalmente con los tejidos que llevan a cabo una rápida división celular, en las neoplasias, durante el desarrollo embrionario y en la respuesta inflamatoria aguda. Sin embargo, los múltiples mecanismos moleculares a través de los que se relaciona la glucólisis anaerobia y el ambiente microtumoral aún no están completamente dilucidados. Este artículo expone los aspectos bioquímicos que muestran cómo la PKM2 tiene una función primordial durante la oncogénesis, especialmente en el efecto Warburg. Éste representa un mecanismo de adaptación en el que, por splicing alternativo el RNA mensajero que codifica para el gen PKM, da lugar a la PKM2, proteína que, en condiciones de hipoxia, promueve un aumento de la viabilidad y de la proliferación celular. Por último, se destaca la utilidad de la PKM2 como biomarcador y posible blanco farmacológico en algunos tipos de cáncer.
COMPACT RADIO SOURCES IN THE FIELD OF TYCHO'S SUPERNOVA REMNANT
Authors: Rodríguez Luis F. , Yanza Vanessa , Dzib Sergio A.
Published: May 2024

We present sensitive, high angular resolution Jansky Very Large Array observations made in 2014 at 1.50 GHz toward the field of Tycho's supernova remnant. We detect a total of 36 compact sources in a field with radius of 13 arcmin. This number is consistent with the expected number of background sources. We use older observations made with the classic Very Large Array to compare with the 2014 observations and search for sources showing large proper motions that could be related to the donor companion of the exploding white dwarf that produced the supernova in 1572. The comparison of the positions for the two sets of observations does not show sources with large proper motions and supports the conclusion that all sources detected are extragalactic and unrelated to the supernova field.
The Crowdfunding Application by Blockchain and ThirdWeb Hybrid Model
Authors: Sawalkar Prof. Meera
Published: May 2024

Abstract: The advancement of Web3 and blockchain is happening rapidly in various fields, including healthcare, social services, and electronic voting. Blockchain technology is being used by crowdfunding platforms to combine its benefits of speed and low fees with traditional finance, creating a new way of raising money. By integrating Reacts user-friendly interface, Solidity smart contracts, Meta-Mask wallet integration and Hardhat development and testing capabilities, it forms a versatile and secure platform. This project aims to find out how much money is missing in the current crowdfunding market and offer them smart contracts and tools that use Ethereum to create their own application businesses. Hybrid Model Platform is a ThirdWeb tool that allows for easy and flexible scaling and visibility. this new crowdfunding app is a major leap in fundraising, fulfilling numerous customer requirements and poised to revolutionize crowdfunding with its fresh and inventive strategy.
Performance of Malayalam Speaking Children Fitted with Hearing Aids on PEACH Scale
Authors: Gupta Dr. Vini Abhijith , Saha Sayon , Biju Irene Elsa
Published: May 2024

Abstract: Parental questionnaires impart a better understanding of hearing technology utilization by children with Hearing loss(HL). They provide insights into the functional abilities and accomplishments of children equipped with Hearing Aids (HA). The present study aimed to translate and adapt the PEACH questionnaire into Malayalam language and evaluating its effectiveness in discriminating the functional hearing abilities of Malayalam speaking children with HL fitted with HAs at various stages of life. The Malayalam PEACH questionnaire was aPdministered to parents/caregivers of 40 Malayalamspeaking children aged 3 to 6, divided into two groups based on whether they received HA before or after the age of 2. Results revealed that children fitted with HA before 2 years of age demonstrated superior performance in quiet, noisy, and overall situations compared to those fitted after 2 years of age highlighting the importance of early identification of HL in children. Additionally, the questionnaire exhibited high reliability upon retesting across all of the three hearing situations (quiet,noise and overall). Therefore, the Malayalam PEACH questionnaire emerges as a dependable and effective tool for evaluating and monitoring the functional hearing abilities and communication skills of children fitted with HA or Cochlear Implants (CI) in their everyday lives
Wooden spoons and “pulling the mom card”: A critical discourse-historical analysis of an interview with a social worker
Authors: David Kendal
Published: May 2024

Despite increasing acknowledgement within and beyond the social work profession of our role in enacting violence against people we claim to care for and serve, discursive strategies that rationalize and naturalize violence are endemic within social work discourse. In this article, I use critical discourse-historical analysis to examine one interview I conducted with a practicing social worker in Alberta, Canada. Grounded in an intersectional critical approach to inquiry, I elucidate how rationalization strategies for professional violence emerge in ordinary social work talk and situate one social worker’s description of her practice within a historical context of the fabrication of social work in Canada. I focus on this social worker’s reports of threatening clients with a “virtual wooden spoon” to identify linguistic and discursive patterns at play and their semiotic significance as means to rationalize and normalize professional power and control. I specifically situate the analysis within the context of social work as a story of racist, classist, and ableist violence often committed by morally exalted, wealthy, white women. I conclude by reflecting on the importance of examining discursive strategies to rationalize, dismiss or diminish violence in our everyday social work talk.
Identity, Power, and Social Work Practice in India
Authors: Vareed Baiju P.
Published: May 2024

A person's identity puts them in different social categories, positions, and statuses. An individual's social position has corresponding power or powerlessness, which influences their interaction with others in the community. The individual identities, social positions, and authority of social workers place them in a higher level of power in relation to the people they serve. This imbalance of power between social workers and clients affects the helping process. This article discusses how personal identity and power influence social work practice in the Indian context. Social structures like caste-based discrimination and patriarchal norms contribute to inequitable social positioning in the country. Following a critical social work approach, the paper presents the different dimensions of power in the social work relationship and proposes means for sharing power with the clients.
Taylor Smith: Passage d’un joueur afro- descendant au Québec, 1899-1900
Authors: Carpentier Patrick
Published: May 2024

African-American baseball player Taylor Smith was long forgotten until an American sports collectoracquired a photo picturing him in his Saint-Jean, Quebec baseball club uniform. This discovery highlightedTaylor Smith’s exceptional career path, from Pennsylvania’s black teams to the famous Cuban Giants, ending upin Quebec at the end of his career with two Provincial League teams. An example of baseball racial integrationlong before Charlie Culver and Jackie Robinson.