bluuebunny/crossref_metadata_2025 huggingface dataset:
New Developments of Hermite–Hadamard Type Inequalities via s-Convexity and Fractional Integrals
Authors: Khan Khuram Ali , Fatima Saeeda , Nosheen Ammara , Matendo Mabela Rostin
Published: January 2024

In this paper, we present an identity for differentiable functions that has played an important role in proving Hermite–Hadamard type inequalities for functions whose absolute values of first derivatives are s-convex functions. Meanwhile, some Hermite–Hadamard type inequalities for the functions whose absolute values of second derivatives are s-convex are also established with the help of an existing identity in literature. Many limiting results are deduced from the main results which are stated in remarks. Some applications of proved results are also discussed in the present study.
Global Longitudinal Strain May Be the One that Appropriately Identifies Candidates of ICD Implantation
Authors: Nikoo Mohammad Hossein , Zarrabi Mohammad , Moaref Alireza , Razeghian-Jahromi Iman
Published: January 2024

Hypertrophic cardiomyopathy (HCM) significantly contributes to an elevated risk of sudden cardiac death. Primary prevention is implemented by using an implantable cardioverter defibrillator (ICD). However, all of the HCM patients do not really need ICD therapy. Providing a superior index for ICD indication compared with the current indices like ejection fraction is essential to differentiate high-risk patients efficiently. The present study assessed the potential of global longitudinal strain (GLS) for the differentiation of HCM patients based on their need for ICD shocks. Patients with HCM were considered in four defined centers between March and June 2021. Those with previous ICD implantation or current candidates for ICD therapy were included in the study. Participants were subjected to speckle-tracking echocardiography, and GLS as well as some other echocardiographic parameters were recorded. Afterwards, data from implanted ICDs were extracted. Patients who received ICD shocks (appropriate) due to ventricular tachycardia (VT)/ventricular fibrillation (VF) were categorized in group A. The remaining patients were constituted group B who received inappropriate shocks, i.e., other than VT/VF. Overall, 34 patients were found eligible to participate with a mean age of 62 ± 16.1 years including 64.7% of males. Among a variety of echocardiographic parameters, GLS was the sole one that was significantly higher in group A compared with that in group B. Our findings revealed that only GLS could predict fatal arrhythmias. To substantiate, the odds of VT were raised by 43% with a single increase in GLS unit. GLS showed the highest accuracy for ICD indication among HCM patients and, therefore, could be a solid and early criterion to predict the incidence of life-threatening arrhythmias. In this regard, identifying appropriate HCM patients with respect to their need for ICD therapy is feasible.
Mechanical Strength and Microstructure Properties of Concrete Incorporating Copper Slag as Fine Aggregate: A State‐of‐the‐Art Review
Authors: Abdalla Tareg Abdalla , Alahmari Turki S.
Published: January 2024

Incorporation solid waste generated in industry into concrete production is considered an environmentally sustainable approach as it reduces pollution, lowers energy consumption, and mitigates the depletion of natural resources. Copper slag (CS) is a residual material produced through the copper smelting process. The slag materials are kept in expansive landfills and consume substantial land space. The typical approaches for managing CS involve recycling, metal recovery, and the creation of additional value through the manufacturing of items, including but not limited to railroad ballast, abrasive tools, cutting tools, roofing granules, abrasive tiles, glass, asphalt surfaces, and foundations for road construction. This study aimed to evaluate the mechanical strength and microstructural properties of concrete, focusing on using CS as a substitute for fine aggregate. This review systematically analyzes its use in concrete production over the last two decades. For the review, data were collected from various publishers, which are peer‐reviewed articles, and validated using databases like Scopus, Scimago journal and country rank (SJR), Web of Science, etc. This review concluded that the potential of utilizing CS as a workable alternative for fine aggregate is highly attractive, given its superior performance in mortar and concrete mixes when compared to mixes without CS.
Scoping Review of Deep Learning Techniques for Diagnosis, Drug Discovery, and Vaccine Development in Leishmaniasis
Authors: Sadeghi Alireza , Sadeghi Mahdieh , Fakhar Mahdi , Zakariaei Zakaria , Sadeghi Mohammadreza
Published: January 2024

Leishmania, a single‐cell parasite prevalent in tropical and subtropical regions worldwide, can cause varying degrees of leishmaniasis, ranging from self‐limiting skin lesions to potentially fatal visceral complications. As such, the parasite has been the subject of much interest in the scientific community. In recent years, advances in diagnostic techniques such as flow cytometry, molecular biology, proteomics, and nanodiagnosis have contributed to progress in the diagnosis of this deadly disease. Additionally, the emergence of artificial intelligence (AI), including its subbranches such as machine learning and deep learning, has revolutionized the field of medicine. The high accuracy of AI and its potential to reduce human and laboratory errors make it an especially promising tool in diagnosis and treatment. Despite the promising potential of deep learning in the medical field, there has been no review study on the applications of this technology in the context of leishmaniasis. To address this gap, we provide a scoping review of deep learning methods in the diagnosis of the disease, drug discovery, and vaccine development. In conducting a thorough search of available literature, we analyzed articles in detail that used deep learning methods for various aspects of the disease, including diagnosis, drug discovery, vaccine development, and related proteins. Each study was individually analyzed, and the methodology and results were presented. As the first and only review study on this topic, this paper serves as a quick and comprehensive resource and guide for the future research in this field.
Multiobjective and Coordinated Reconfiguration and Allocation of Photovoltaic Energy Resources in Distribution Networks Using Improved Clouded Leopard Optimization Algorithm
Authors: Alanazi Mohana , Alanazi Abdulmajeed , AboRas Kareem M. , Ghadi Yazeed Yasin
Published: January 2024

In this paper, a multiobjective framework for simultaneous reconfiguration and allocation of photovoltaic (PV) energy resources in radial distribution networks is performed for minimizing the power losses, lowering network loading factor, and reducing cost of energy resources as well as increasing the voltage stability index. A novel algorithm called the improved clouded leopard algorithm is used to find the set of optimum decision factors in the combined execution of restructuring and also PV resource distribution. The clouded leopard optimization (CLO) algorithm, which is widely used, takes its cues from the sleeping and foraging habits of the animal, and the improved CLO (ICLO) is formed using adaptive inertia weight to overcome premature convergence. In five cases of base distribution network and different contribution of reconfiguration and PV allocation, single‐ and multiobjective approach has been applied on 33‐ and 69‐bus distribution networks. According to the findings, the best case includes simultaneous reconfiguration and PV allocation in the radial networks based on the multiobjective approach unlike the single‐objective method which obtained the highest network performance with the best compromise between different goals. Also, in the best lowest losses, the decrease in the network loading and cost of energy resources and the better voltage profile and stability are obtained satisfying the constraints. The losses, network loading, voltage profile, and voltage stability are improved by 60.40%, 37.89%, 6.17%, and 27.5% for 33‐bus network and also enhanced by 71.77%, 41.23%, 4.76%, and 20.48% for 69‐bus network, respectively. Also, the results showed that network reconfiguration only has the weakest performance among other cases based on reconfiguration or photovoltaic sources. Moreover, the superior capability of the ICLO in addressing the aim of the study is proved in comparison with the traditional CLO and well‐known particle swarm optimization (PSO) and manta ray foraging optimization (MRFO) to obtain the better objective value and statistical criteria to solve the best case.
Meningeal Solitary Fibrous Tumor: A Single-Center Retrospective Cohort Study
Authors: Roohani Siyer , Alberti Yasemin , Mirwald Maximilian , Ehret Felix , Stromberger Carmen , Roohani Soleiman Fabris , Bender Katja , Flörcken Anne , Märdian Sven , Zips Daniel , Kaul David
Published: January 2024

Background. Meningeal solitary fibrous tumors (SFTs) are rare, malignant, mesenchymal tumors of the central nervous system. While surgical gross total resection is widely accepted as a positive prognostic factor for local control (LC), the role of postoperative radiotherapy (PORT) remains controversial. We sought to report our institutional experience with a particular focus on outcomes after PORT. Materials and Methods. In this single-center, retrospective cohort study, 20 patients with the primary diagnosis of histopathologically confirmed meningeal SFT were analyzed. Data on patient characteristics, imaging, treatment modalities, histopathology, and oncological outcomes were collected. LC and overall survival (OS) were assessed using the Kaplan–Meier estimator. Results. The median follow-up time was 95.8 months. After surgery only, 9 out of 11 patients (81.8%) developed a local recurrence while, after surgery and PORT, 3 out of 9 patients (33.33%) showed local failure. The 5- and 10-year LC rates were 50.5% and 40.4% in the surgery-only group and 80% at both time points in the surgery with the PORT group. In the surgery-only group, 4 out of 11 patients (36.4%) died, and 4 out of 9 patients (44.4%) died in the surgery and PORT group. OS rates after 5 and 10 years were 88.9% and 66.7% in the surgery-only group and 88.9% and 76.2% in the surgery with PORT group. Conclusions. Our findings suggest that PORT may improve LC in patients with meningeal SFT. The low incidence of meningeal SFT impedes prospective studies and requires further international collaborative efforts to exploit retrospective datasets and molecular analysis to improve patient outcomes.
Synthesis and Antibacterial Activity of Grafted Poly(Vinyl Chloride) Polymer against Gram-Positive and Gram-Negative Bacteria
Authors: Kotian Shrajan , Gupta Sonali , Puttaiahgowda Yashoda Malgar , Shetty Sanmit
Published: January 2024

Infectious diseases caused by microorganisms have gained worldwide attention in recent years. According to data compiled by the World Health Organization, the number of deaths resulting from infectious diseases is on the rise. In light of these dangers, the study of antibacterial materials has become increasingly vital. In this research, an antibacterial polymer was developed using poly(vinyl chloride) (PVC) and 4,4-diamminodiphenylmethane (DDM). The produced polymer’s chemical structure and thermal properties were investigated using Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and thermo-gravimetric analysis. The antibacterial activity of the resulting PVC-g-DDM polymer was effective in killing both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The antimicrobial efficacy was tested using a spread plate method, demonstrating its potential utility in a variety of applications like biomedical, coatings, water purification systems, and others. Antimicrobial resistance is increasing, especially among bacteria that have acquired resistance to multiple therapeutics. To fully optimize and explore the polymer’s potential and its usage, more research is needed.
Supplementary Table S6 from Pilot Study of High-Dose Pemetrexed in Patients with Progressive Chordoma
Authors: Kesari Santosh , Wagle Naveed , Carrillo Jose A. , Sharma Akanksha , Nguyen Minhdan , Truong Judy , Gill Jaya M. , Nersesian Raffi , Nomura Natsuko , Rahbarlayegh Elnaz , Barkhoudarian Garni , Sivakumar Walavan , Kelly Daniel F. , Krauss Howard , Bustos Matias A. , Hoon Dave S.B. , Anker Lars , Singh Arun S. , Sankhala Kamalesh K. , Juarez Tiffany M.
Published: January 2024

Table S6. Representativeness of Study Participants
Table S1 from Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma
Authors: Pan Minggui , Zhou Maggie Yuxi , Jiang Chen , Zhang Zheyang , Bui Nam Q. , Bien Jeffrey , Siy Amanda , Achacoso Ninah , Solorzano Aleyda V. , Tse Pamela , Chung Elaine , Thomas Sachdev , Habel Laurel A. , Ganjoo Kristen N.
Published: January 2024

Demographics of patients with wt and mut TP53.
Table S3 from Phase I/IIa Trial in Advanced Pancreatic Ductal Adenocarcinoma Treated with Cytotoxic Drug-Packaged, EGFR-Targeted Nanocells and Glycolipid-Packaged Nanocells
Authors: Ganju Vinod , Marx Gavin , Pattison Scott , Amaro-Mugridge Nancy B. , Zhao Jing-Ting , Williams Bryan R.G. , MacDiarmid Jennifer A. , Brahmbhatt Himanshu
Published: January 2024

Table S3: Measurement of αGC Packaged in EDVs
Supplementary Table S4 from Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial
Authors: Ou Xiaomin , Zhai Ruiping , Wei Wenjun , Chen Jiaying , Ou Dan , Liao Tian , Xu Tingting , Zhu Yongxue , Wang Yulong , Huang Shenglin , Shi Rongliang , Wu Bin , Chen Tongzhen , Li Yuan , Yang Zhongyi , Zhou Changming , Liu Yuan , Jiang Ziting , Zeng Min , Liu Xin , Ji Dongmei , Ying Hongmei , Zhang Zhen , Hu Chaosu , Lu Xueguan , Ji Qinghai , He Xiayun , Wang Yu
Published: January 2024

Details of radiotherapy (N=27)
Supplementary Table S3 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Table S3. Summary of TEC-Seq characteristics for plasma and matched WBC samples analyzed.
Supplementary Table S13 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Table S13. Summary of GLIPH2 TCR clustering analyses across patients analyzed.
Supplementary Table S12 from Elucidating the Heterogeneity of Immunotherapy Response and Immune-Related Toxicities by Longitudinal ctDNA and Immune Cell Compartment Tracking in Lung Cancer
Authors: Murray Joseph C. , Sivapalan Lavanya , Hummelink Karlijn , Balan Archana , White James R. , Niknafs Noushin , Rhymee Lamia , Pereira Gavin , Rao Nisha , Weksler Benny , Bahary Nathan , Phallen Jillian , Leal Alessandro , Bartlett David L. , Marrone Kristen A. , Naidoo Jarushka , Goel Akul , Levy Benjamin , Rosner Samuel , Hann Christine L. , Scott Susan C. , Feliciano Josephine , Lam Vincent K. , Ettinger David S. , Li Qing Kay , Illei Peter B. , Monkhorst Kim , Scharpf Robert B. , Brahmer Julie R. , Velculescu Victor E. , Zaidi Ali H. , Forde Patrick M. , Anagnostou Valsamo
Published: January 2024

Supplementary Table S12. Summary of global TCR clusters identified in at least 3 distinct patients using GLIPH2.
Figure 3 from Developing and Validating a Multivariable Prognostic-Predictive Classifier for Treatment Escalation of Oropharyngeal Squamous Cell Carcinoma: The PREDICTR-OPC Study
Authors: Mehanna Hisham , Rapozo Davy , von Zeidler Sandra V. , Harrington Kevin J. , Winter Stuart C. , Hartley Andrew , Nankivell Paul , Schache Andrew G. , Sloan Philip , Odell Edward W. , Thavaraj Selvam , Hunter Keith D. , Shah Ketan A. , Thomas Gareth J. , Long Anna , Amel-Kashipaz Rasoul , Brown Rachel M. , Conn Brendan , Hall Gillian L. , Matthews Paul , Weir Justin , Yeo Yen , Pring Miranda , West Catharine M.L. , McCaul James , Golusinski Pawel , Sitch Alice , Spruce Rachel , Batis Nikolaos , Bryant Jennifer L. , Brooks Jill M. , Jones Terence M. , Buffa Francesca , Haider Syed , Robinson Max
Published: January 2024

A–C, Prognostic and predictive assessment of risk groups predicted by multivariable survival model (trained with backward elimination using AIC) based on molecular biomarkers only with OS, when applied to the training cohort. D–F, Prognostic and predictive assessment of risk groups predicted by the molecular biomarkers only multivariable model, when applied to the validation cohort. Risk groups in the validation cohort were created using the thresholds (two-group classification: median risk score; three-group classification: tertiles of risk score) derived from the training set. Color key A, D: black = low-risk group, red = high-risk group; B, E: black = low-risk, red = intermediate (Int.)-risk, Blue=high-risk group; C, F: Red = low-risk surgery, black = low-risk no surgery, pink = high-risk surgery, blue = high-risk no surgery group. Models were adjusted for clinical covariates: T-category, N-category, smoking status, age, radiotherapy, and chemotherapy.
Supplementary Table 1 from Association of Molecular Subtypes with Pathologic Response, PFS, and OS in a Phase II Study of COXEN with Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer
Authors: Lerner Seth P. , McConkey David J. , Tangen Catherine M. , Meeks Joshua J. , Flaig Thomas W. , Hua Xing , Daneshmand Siamak , Alva Ajjai Shivaram , Lucia M. Scott , Theodorescu Dan , Goldkorn Amir , Milowsky Matthew I. , Choi Woonyoung , Bangs Rick , Gustafson Daniel L. , Plets Melissa , Thompson Ian M.
Published: January 2024

Three-way classifier comparison for n=155 patients
Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Authors: Dunbar Andrew J. , Bowman Robert L. , Park Young C. , O'Connor Kavi , Izzo Franco , Myers Robert M. , Karzai Abdul , Zaroogian Zachary , Kim Won Jun , Fernández-Maestre Inés , Waarts Michael R. , Nazir Abbas , Xiao Wenbin , Codilupi Tamara , Brodsky Max , Farina Mirko , Cai Louise , Cai Sheng F. , Wang Benjamin , An Wenbin , Yang Julie L. , Mowla Shoron , Eisman Shira E. , Hanasoge Somasundara Amritha Varshini , Glass Jacob L. , Mishra Tanmay , Houston Remie , Guzzardi Emily , Martinez Benitez Anthony R. , Viny Aaron D. , Koche Richard P. , Meyer Sara C. , Landau Dan A. , Levine Ross L.
Published: January 2024

Gain-of-function mutations activating JAK/STAT signaling are seen in the majority of patients with myeloproliferative neoplasms (MPN), most commonly JAK2V617F. Although clinically approved JAK inhibitors improve symptoms and outcomes in MPNs, remissions are rare, and mutant allele burden does not substantively change with chronic therapy. We hypothesized this is due to limitations of current JAK inhibitors to potently and specifically abrogate mutant JAK2 signaling. We therefore developed a conditionally inducible mouse model allowing for sequential activation, and then inactivation, of Jak2V617F from its endogenous locus using a combined Dre-rox/Cre-lox dual-recombinase system. Jak2V617F deletion abrogates MPN features, induces depletion of mutant-specific hematopoietic stem/progenitor cells, and extends overall survival to an extent not observed with pharmacologic JAK inhibition, including when cooccurring with somatic Tet2 loss. Our data suggest JAK2V617F represents the best therapeutic target in MPNs and demonstrate the therapeutic relevance of a dual-recombinase system to assess mutant-specific oncogenic dependencies in vivo.

Significance:

Current JAK inhibitors to treat myeloproliferative neoplasms are ineffective at eradicating mutant cells. We developed an endogenously expressed Jak2V617F dual-recombinase knock-in/knock-out model to investigate Jak2V617F oncogenic reversion in vivo. Jak2V617F deletion abrogates MPN features and depletes disease-sustaining MPN stem cells, suggesting improved Jak2V617F targeting offers the potential for greater therapeutic efficacy.

See related commentary by Celik and Challen, p. 701.

This article is featured in Selected Articles from This Issue, p. 695
Supplementary File 6 from WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers
Authors: Sottnik Joseph L. , Shackleford Madeleine T. , Robinson Sydney K. , Villagomez Fabian R. , Bahnassy Shaymaa , Oesterreich Steffi , Hu Junxiao , Madak-Erdogan Zeynep , Riggins Rebecca B. , Corr Bradley R. , Cook Linda S. , Treviño Lindsey S. , Bitler Benjamin G. , Sikora Matthew J.
Published: January 2024

ILC tumor metabolic gene expression
Late-Onset Haze and Severe Corneal Flattening after Combined Corneal Collagen Cross-Linking and Photorefractive Keratectomy (CXL Plus): A Case Report
Authors: Mazouchi Marjan , Hassanpour Kiana , Esfandiari Hamed , Sadoughi Mohammad-Mehdi
Published: January 2024

Introduction: Significant corneal flattening and haze are important complications that can occur after combined corneal collagen cross-linking (CXL) and photorefractive keratectomy (PRK) procedures (CXL Plus). Case Presentation: We present a 24-year-old man who underwent combined standard CXL and PRK. The patient experienced satisfactory vision for approximately 4 years after the surgery. However, after this period, he began to complain of visual blurring. Subsequent examination revealed significant corneal haze, excessive flattening in both eyes, and thinning (thinnest point 227 μm in the right eye, 244 μm in the left eye) 4 years postoperatively. Upon presentation, the corrected distance visual acuity (CDVA) was 20/200 in the right eye and 20/400 in the left eye. The presenting refraction was +2.50 sph, −3.50 cyl *114 in the right eye and +11.5 sph, −9.75 cyl *81 in the left eye. With rigid gas permeable contact lenses, the corrected visual acuity was 20/50 in both eyes. Before the CXL Plus surgery, initial refraction and CDVA were 20/50 in the right eye (−5.50 sph, −3.00 cyl *175) and 20/30 in the left eye (−5.50 sph, −2.75 cyl *175). The patient was treated by penetrating keratoplasty. The CDVA reached 20/30 at the final follow-up. Conclusion: Our report highlights significant corneal haze and flattening that occurred 4 years after combined CXL and PRK treatment. These findings suggest that this procedure might not be safe in suspected patients of keratoconus. Further long-term follow-up research is necessary to evaluate the safety of combined CXL and PRK procedures.
América Latina, internacionalização e reciprocidade acadêmica
Authors: Paulino Fernando Oliveira
Published: January 2024

O objetivo deste artigo é estimular uma análise reflexiva sobre as ações da Associação Latino-Americana de Investigadores da Comunicação, tomando como referência seu propósito de ser um suporte institucional para a internacionalização e os desequilíbrios e desafios da internacionalização do campo. O texto procurou sistematizar as principais ações e bases conceituais, políticas e acadêmicas que têm guiado as ações de cooperação da associação. Conclui-se que existe um esforço de maior diálogo dentro e fora da América Latina, pautado na ideia de horizontalidade e reciprocidade acadêmica, por meio de iniciativas que promovam a circulação de conteúdos e que utilizem as tecnologias de informação e comunicação contemporâneas.
"Que cabelo é esse?”: uma narrativa antropológica em torno das tecnologias capilares afrodiaspóricas
Authors: Santos Luane Bento dos
Published: January 2024

Este texto tem por objetivo discorrer acerca da trajetória de estudos da pesquisadora no campo da Antropologia Social e das Relações Étnico-raciais. Para isso, o artigo descreve os processos de elaborações intelectuais e investigações etnográficas que foram realizados pela pesquisadora durante a realização das pesquisas. O trabalho apresenta as principais preocupações e perguntas que existiram durante a execução das pesquisas. Os temas abordados no texto são os processos de construção da identidade negra a partir do corpo e cabelo e a reivindicação das trabalhadoras conhecidas como trancistas e trançadeiras afro, enquanto uma categoria ocupacional distinta das cabeleireiras/os. os métodos e técnicas de pesquisas utilizados foram: Etnografia, observação participante, entrevistas semiestruturadas, revisão de literatura e levantamento bibliográfico
Explorando topologias possíveis: escrevinhando movimentações nos rituais abakuás
Authors: Lucena Francisca Marcela Andrade
Published: January 2024

O ensaio segue as diferentes etapas do ritual Plante realizado pela sociedade abakuá, uma confraria masculina responsável por práticas religiosas e ações sociais de ajuda mútua em Cuba. O ensaio mostra um jogo entre as dimensões externas e internas presentes nas movimentações espaciais formuladas pelo sagrado durante o referido ritual. As fotografias são sempre externas e distanciadas e, de diferentes pontos de vista, capturam a árvore sagrada Ceiba e as posições ocupadas pelos abakuás em momentos centrais do Plante. Os diagramas, por sua vez, buscam retraçar as movimentações e direções rituais (feitas somente pelos homens) e as posicionalidades da Ceiba, do templo e das mulheres que observam o ritual externamente. Diagramas e fotografias produzem, então, uma topologia própria do fazer etnográfico.
Uma cidade condenada ao canibalismo: Declamatio Maior XII, de Pseudo-Quintiliano
Authors: Miotti Charlene Martins , Furtado Fernando Miranda Fiorese
Published: January 2024

Este artigo apresenta uma proposta de tradução em português brasileiro da décima segunda peça das Declamationes Maiores, obra situada entre os séculos II e IV da era comum, atribuída pela tradição a Quintiliano (30-96 e.c.) ou a seus asseclas. A Declamatio Maior XII, com vinte e oito parágrafos, é a mais extensa do conjunto de dezenove declamações, marcado pela temática do macabro e do profano. A tradução é precedida pela contextualização da obra com sucintas informações sobre a suposta autoria, vinculação ao gênero oratório, conjuntura histórica da Roma imperial, marcas intertextuais e recursos poéticos em prosa.
Clonal Hematopoiesis of Indeterminate Potential in Chronic Thromboembolic Pulmonary Hypertension: A Multicenter Study
Authors: Liu Chao , Zhou Yu-Ping , Lian Tian-Yu , Li Ruo-Nan , Ma Jing-Si , Yang Yin-Jian , Zhang Si-Jin , Li Xian-Mei , Qiu Lu-Hong , Qiu Bao-Chen , Ren Li-Yan , Wang Jia , Han Zhi-Yan , Li Jing-Hui , Wang Lan , Xu Xi-Qi , Sun Kai , Chen Lian-Feng , Cheng Chun-Yan , Zhang Ze-Jian , Jing Zhi-Cheng
Published: January 2024

BACKGROUND:

The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) is multifactorial and growing evidence has indicated that hematological disorders are involved. Clonal hematopoiesis of indeterminate potential (CHIP) has recently been associated with an increased risk of both hematological malignancies and cardiovascular diseases. However, the prevalence and clinical relevance of CHIP in patients with CTEPH remains unclear.

METHODS:

Using stepwise calling on next-generation sequencing data from 499 patients with CTEPH referred to 3 centers between October 2006 and December 2021, CHIP mutations were identified. We associated CHIP with all-cause mortality in patients with CTEPH. To provide insights into potential mechanisms, the associations between CHIP and inflammatory markers were also determined.

RESULTS:

In total, 47 (9.4%) patients with CTEPH carried at least 1 CHIP mutation at a variant allele frequency of ≥2%. The most common mutations were in
DNMT3A
,
TET2
,
RUNX1
, and
ASXL1
. During follow-up (mean, 55 months), deaths occurred in 22 (46.8%) and 104 (23.0%) patients in the CHIP and non-CHIP groups, respectively (
P
<0.001, log-rank test). The association of CHIP with mortality remained robust in the fully adjusted model (hazard ratio, 2.190 [95% CI, 1.257–3.816];
P
=0.006). Moreover, patients with CHIP mutations showed higher circulating interleukin-1β and interleukin-6 and lower interleukin-4 and IgG galactosylation levels.

CONCLUSIONS:

This is the first study to show that CHIP mutations occurred in 9.4% of patients with CTEPH are associated with a severe inflammatory state and confer a poorer prognosis in long-term follow-up.
Embodying Spatial Sound Synthesis with AI in Two Compositions for
Instruments and 3-D Electronics
Authors: Einbond Aaron , Carpentier Thibaut , Schwarz Diemo , Bresson Jean
Published: January 2024

The situated spatial presence of musical instruments has been well studied in the fields of acoustics and music perception research, but so far it has not been the focus of human–AI interaction. We respond critically to this trend by seeking to reembody interactive electronics using data derived from natural acoustic phenomena. Two musical works, composed for human soloist and computer-generated live electronics, are intended to situate the listener in an immersive sonic environment in which real and virtual sources blend seamlessly. To do so, we experimented with two contrasting reproduction setups: a surrounding Ambisonic loudspeaker dome and a compact spherical loudspeaker array for radiation synthesis. A large database of measured radiation patterns of orchestral instruments served as a training set for machine learning models to control spatially rich 3-D patterns for electronic sounds. These are exploited during performance in response to live sounds captured with a spherical microphone array and used to train computer models of improvisation and to trigger corpus-based spatial synthesis. We show how AI techniques are useful to utilize complex, multidimensional, spatial data in the context of computer-assisted composition and human–computer interactive improvisation.
Identification of rare cortical folding patterns using unsupervised deep learning
Authors: Guillon Louise , Chavas Joël , Bénézit Audrey , Moutard Marie-Laure , Roca Pauline , Mellerio Charles , Oppenheim Catherine , Rivière Denis , Mangin Jean-François
Published: January 2024

Like fingerprints, cortical folding patterns are unique to each brain even though they follow a general species-specific organization. Some folding patterns have been linked with neurodevelopmental disorders. However, due to the high inter-individual variability, the identification of rare folding patterns that could become biomarkers remains a very complex task. This paper proposes a novel unsupervised deep learning approach to identify rare folding patterns and assess the degree of deviations that can be detected. To this end, we preprocess the brain MR images to focus the learning on the folding morphology and train a beta variational auto-encoder (β−VAE) on the inter-individual variability of the folding to identify outliers. We compare the detection power of the latent space and of the reconstruction errors, using synthetic benchmarks and one actual rare configuration related to the central sulcus. Finally, we assess the generalization of our method on a developmental anomaly located in another region and we validate the relevance of our approach on patients suffering from drug-resistant epilepsy. Our results suggest that this method enables encoding relevant folding characteristics that can be enlightened and better interpreted based on the generative power of the β−VAE. The latent space and the reconstruction errors bring complementary information and enable the identification of rare patterns of different nature. This method generalizes well to a different region on another dataset and demonstrates promising results on the epileptic patients. Code is available at https://github.com/neurospin-projects/2022_lguillon_rare_folding_detection.
Mycena lamprocephala, a new luminescent species from the Brazilian Amazon
Authors: SOARES CÉLIA C.B. , CABRAL TIARA S. , VARGAS-ISLA RUBY , CARDOSO JULI S. , RODRIGUES DORIANE P. , ISHIKAWA NOEMIA K. , OLIVEIRA JADSON J.S.
Published: January 2024

A luminescent fungus growing on decaying leaves and sticks was collected in terra-firme forest at the upper Cuieiras river, Amazonas, Brazil. Morphological study and phylogenetic analysis (based on ITS+LSU data) confirmed it as a new species of Mycena. Mycena lamprocephala sp. nov. is characterized macroscopically by small, thin, basidiomata with an olivaceous brown pileus and glutinous stipe, and microscopically by diverticulate pleurocystidia, ramose cheilocystidia, and thin, diverticulate and branching pileipellis hyphae. The luminescence of the pileus and of the mycelium in the substrate is typically green and sometimes pulsating. This is the third luminescent species of Mycenaceae described from the Amazon Forest.
One steps out of line—A “modern” Micraster species (Echinoidea, Spatangoida) with some old-fashioned look, Micraster ernsti sp. nov. from the Campanian (Cretaceous)
Authors: SCHLÜTER NILS
Published: January 2024

A new species of the micrasterid genus Micraster, Micraster ernsti sp. nov., is described from the Lower Campanian from the Hannover area (Lower Saxony, Germany). This species shows a peristome which is not close to the anterior margin, an only moderately-projecting labrum with a smooth rim and well-developed phyllodes, in contrast to contemporary Micraster species. These morphologies may have been the result of an adaptation to feeding from within the inhabited sediment, rather than from the sediment-water interface. This feeding strategy unveils an ecological niche not occupied by the co-occurring Micraster species.
The Mechanism of Fuzheng Xiaoji Decoction in the Treatment of Non-Small Cell Lung Cancer Based on Network Pharmacology and Molecular Docking Technology
Authors: Deng Xiaolan , Cui Weiheng , Li Fuling , Chen Xiaoliang , Wang Siqin
Published: January 2024

With approximately 2 million lung cancer patients and 1.8 million deaths per year, the world ranks among the highest incidence rates in the world. Non-small cell lung cancer (NSCLC) accounts for up to 85% of lung cancer patients and has a poor prognosis. To investigate the mechanism
of Fuzheng Xiaoji Decoction in the treatment of NSCLC. Fuzheng Xiaoji Decoction, consisting of ten traditional Chinese medicines, was analyzed using the TCMSP database to identify its active ingredients and their corresponding targets. Simultaneously, NSCLC-related targets were obtained from
GeneCards. The study aimed to predict Fuzheng Xiaoji Decoction’s targets in treating NSCLC and establish a network diagram illustrating the relationship between traditional Chinese medicine, active ingredients, targets, and the disease. The STRING platform was used to construct a PPI
network, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Gene Ontology (GO) function enrichment analysis were performed on the intersecting targets. Based on the interaction network analysis, the core target proteins, represented by the TOP5 nodes with the highest degrees,
were selected. These core targets were then subjected to molecular docking with the top five key active components of Fuzheng Xiaoji Decoction to construct the docking model. We identified 132 active components in Fuzheng Xiaoji Decoction and picked the TOP 5 proteins from the PPI network
as the primary active elements in Fuzheng Xiaoji Decoction for NSCLC treatment, including kaempferol, quercetin, ingenin, luteolin, and osterol, involving a total of 209 targets. The top five core targets obtained by PPI network were AKT1, TP53, STAT3, TNF and IL6. A total of 7879 targets
related to NSCLC were retrieved, and 164 drug-disease intersection targets were identified. GO functional analysis results showed that 164 gene sets were involved in 377 biological processes, mainly involved in 79 processes related to cell composition and 46 molecular function expression processes.
KEGG enrichment results showed 132 significantly enriched signaling pathways. Molecular docking findings indicated favorable binding interactions between the receptor and ligand, suggesting a strong affinity between the key NSCLC treatment protein and the primary active ingredient in Fuzheng
Xiaoji Decoction. The potential mechanism of Fuzheng Xiaoji Decoction in NSCLC treatment may involve flavonoids, triterpenoids and other compounds regulate lung cancer-related signaling pathways by acting on AKT1, TP53, STAT3 and other proteins to affect the expression of P53, IL6 and other
cytokines. This may help regulate immune function and inhibit tumor cell proliferation.
A Glimpse into the Future: The 2023 Ocean Temperature and Sea Ice Extremes in the Context of Longer-Term Climate Change
Authors: Kuhlbrodt Till , Swaminathan Ranjini , Ceppi Paulo , Wilder Thomas
Published: January 2024

In the year 2023, we have seen extraordinary extrema in high sea surface temperature (SST) in the North Atlantic and in low sea ice extent in the Southern Ocean, outside the 4σ envelope of the 1982–2011 daily time series. Earth’s net global energy imbalance (12 months up to September 2023) amounts to +1.9 W m−2 as part of a remarkably large upward trend, ensuring further heating of the ocean. However, the regional radiation budget over the North Atlantic does not show signs of a suggested significant step increase from less negative aerosol forcing since 2020. While the temperature in the top 100 m of the global ocean has been rising in all basins since about 1980, specifically the Atlantic basin has continued to further heat up since 2016, potentially contributing to the extreme SST. Similarly, salinity in the top 100 m of the ocean has increased in recent years specifically in the Atlantic basin, and in addition in about 2015 a substantial negative trend for sea ice extent in the Southern Ocean began. Analyzing climate and Earth system model simulations of the future, we find that the extreme SST in the North Atlantic and the extreme in Southern Ocean sea ice extent in 2023 lie at the fringe of the expected mean climate change for a global surface-air temperature warming level (GWL) of 1.5°C, and closer to the average at a 3.0°C GWL. Understanding the regional and global drivers of these extremes is indispensable for assessing frequency and impacts of similar events in the coming years.
Global Evaluation of Simulated High and Low Flows from 23 Macroscale Models
Authors: Guo Hui , Hou Ying , Yang Yuting , McVicar Tim R.
Published: January 2024

Macroscale hydrological/land surface models are important tools for assessing historical and predicting future characteristics of extreme hydrological events, yet quantitative understandings of how these large-scale models perform in simulating extreme hydrological characteristics remain limited. Here we evaluate simulated high and low flows from 23 macroscale models within three modeling experiments (i.e., 14 climate models from CMIP6, 6 global hydrological models from ISIMIP2a, and 3 land surface models from GLDAS) against observation in 633 unimpaired catchments globally over 1971–2010. Our findings reveal limitations in simulating extreme flow characteristics by these models. Specifically, we find that (i) most models overestimate high-flow magnitudes (bias range: from +15% to +70%) and underestimate low-flow magnitudes (bias range: from −80% to −20%); (ii) interannual variability in high and low flows is reasonably reproduced by ISIMIP2a and GLDAS models but poorly reproduced by CMIP6 models; (iii) no model consistently replicates the observed trend direction in high and low flows in over two-thirds of the catchments, and most models overestimate high-flow trends and underestimate low-flow trends; and (iv) CMIP6 and GLDAS models show timing biases, with early high flows and late low flows, while ISIMIP2a models exhibit the opposite pattern. Furthermore, all models performed better in more humid environments and noncold regions, with model structure and parameterization contributing more to uncertainties than climatic forcings. Overall, our results demonstrate that extreme flow characteristics simulated from current state-of-the-art macroscale models still contain large uncertainties and provide important guidance regarding the robustness of assessing extreme hydrometeorological events based on these modeling outputs.

Significance Statement

Macroscale hydrological and land surface models represent crucial tools for assessing historical trends and making predictions about future hydrological changes. Nevertheless, our current understanding of the quantitative performance of these large-scale models in simulating extreme hydrological characteristics remains limited. Here, we evaluate simulated high and low flows from 23 state-of-the-art macroscale models against observation in 633 unimpaired catchments globally over 1971–2010. Our results reveal important limitations in the extreme flow characteristics simulated from these models and provide important guidance regarding the robustness of assessing extreme hydrometeorological events based on these modeling outputs. The model evaluation performed herein serves as a pivotal, offering valuable insights to inform the development of the next generation of macroscale hydrological and land surface models.
A Generalized Slab Model
Authors: Stokes Ian A. , Kelly Samuel M. , Lucas Andrew J. , Waterhouse Amy F. , Whalen Caitlin B. , Klenz Thilo , Hormann Verena , Centurioni Luca
Published: January 2024

We construct a generalized slab model to calculate the ocean’s linear response to an arbitrary, depth-variable forcing stress profile. To introduce a first-order improvement to the linear stress profile of the traditional slab model, a nonlinear stress profile, which allows momentum to penetrate into the transition layer (TL), is used [denoted mixed layer/transition layer (MLTL) stress profile]. The MLTL stress profile induces a twofold reduction in power input to inertial motions relative to the traditional slab approximation. The primary reduction arises as the TL allows momentum to be deposited over a greater depth range, reducing surface currents. The secondary reduction results from the production of turbulent kinetic energy (TKE) beneath the mixed layer (ML) related to interactions between shear stress and velocity shear. Direct comparison between observations in the Iceland Basin, the traditional slab model, the generalized slab model with the MLTL stress profile, and the Price–Weller–Pinkel (PWP) model suggest that the generalized slab model offers improved performance over a traditional slab model. In the Iceland Basin, modeled TKE production in the TL is consistent with observations of turbulent dissipation. Extension to global results via analysis of Argo profiling float data suggests that on the global, annual mean, ∼30% of the total power input to near-inertial motions is allocated to TKE production. We apply this result to the latest global, annual-mean estimates for near-inertial power input (0.27 TW) to estimate that 0.08 ± 0.01 TW of the total near-inertial power input are diverted to TKE production.
CT-Diagnosed Non-Alcoholic Fatty Liver Disease as a Risk Predictor of Symptomatic Carotid Plaque and Cerebrovascular Symptoms
Authors: Xu Tianqi , Wang Li , Chang Na , Li Sha , Jiao Bingxuan , Zhang Shuai , Wang Ximing
Published: January 2024

We aimed to test whether computed tomography (CT)-diagnosed Non-Alcoholic Fatty Liver Disease (NAFLD) is a risk factor for cerebrovascular symptoms in patients with suspected atherosclerotic disease. A total of 550 patients (mean age 65.2 ± 8.8 years, 370 males) with carotid plaques who underwent carotid computed tomographic angiography (CTA) and unenhanced abdominal CT were retrospectively analyzed. NAFLD was diagnosed by abdominal CT. Carotid CTA assessed the presence of carotid artery stenosis or plaque. The relationship between NAFLD and cerebrovascular symptoms was analyzed using generalized estimating equations and receiver operating characteristic (ROC) analysis. The prevalence of NAFLD was significantly higher in symptomatic patients (76.5 vs 9.8%; P < .001). After adjusting for several confounding factors (e.g., hypertension and hyperlipidemia), univariate and multivariate logic regression analysis revealed that NAFLD was still strongly associated with cerebrovascular symptoms (odds ratio, 22.81; 95% CI 13.03–39.93; P < .001). ROC analysis showed that the area under the curve for discriminating symptomatic and asymptomatic plaques using NAFLD measurements was 0.833, with a sensitivity of 76.5% and a specificity of 90.2%. NAFLD is strongly associated with an increased risk of cerebrovascular symptoms. It may be an important predictor of symptomatic carotid plaque and cerebrovascular symptoms.
A Systematic Review and Meta-Analysis of the Impacts of Time-Restricted Eating on Metabolic Homeostasis
Authors: Qi Dan , Nie Xiaolu , Zhang Jianjun
Published: January 2024

This meta-analysis investigated the effect of time-restricted eating (TRE) as an economical lifestyle intervention for the prevention of metabolic syndrome and improving the related metabolic variables. The Cochrane library, MEDLINE, EMBASE, clinical trials, and other databases were searched for randomized controlled trials (RCTs). We included 22 RCTs (1004 participants, aged 18–75 years, including healthy subjects, prediabetes and overweight patients) designed to evaluate the effect of TRE on metabolic parameters. Body mass index (BMI) (-0.56 kg/m2, 95% CI: -1.00, -0.13, P < .01), fasting blood glucose (-1.74 mmol/L, 95% CI: -3.34, -0.14, P < .01), and body weight (-0.48 kg, 95% CI: -0.74, -0.22, P < .01) in the TRE intervention group were decreased to varying degrees compared with controls. In contrast, high-density lipoprotein cholesterol (HDL-C) levels were significantly increased in the TRE group compared with the control group ( P < .01). The change in waist circumference, blood pressure, triglycerides, low-density lipoprotein cholesterol (LDL-C), and total cholesterol did not vary markedly across the groups. In conclusion, this meta-analysis found a significant reduction in BMI, weight, and fasting glucose, as well as a rise in HDL-C level with TRE compared with control. TRE could be used as an adjuvant treatment for metabolic dysfunctions.