bluuebunny/crossref_metadata_2025 huggingface dataset:
PRÁTICAS EPISTÊMICAS E A ABORDAGEM STEM/STEAM NO ENSINO DE CIÊNCIAS: UMA REVISÃO SISTEMÁTICA DA LITERATURA
Authors: Jesus Daniela Santos de , Wartha Edson José
Published: June 2024

O objetivo deste artigo é investigar, no período de 2018 a 2022, como as práticas epistêmicas estão dissolvidas no ensino de ciências, além de fazer uma busca que relacione práticas epistêmicas à abordagem STEM/STEAM, através de uma Revisão Sistemática da Literatura (RSL). Foram utilizadas como fonte de pesquisa as bases Google Acadêmico, Eric e Springer Link. Ao todo, foram levantados 593 artigos referentes à temática investigada, dos quais foram selecionados 35 artigos. No Brasil, os resultados apontam que as pesquisas no campo das Práticas Epistêmicas e STEAM/STEM estão dissociadas, porém, no exterior, é possível enxergar essa conexão, o que justifica a necessidade de futuros trabalhos nessa linha, em especial no Brasil, onde não foram encontrados. Além disso, foram identificados os principais autores que trabalham nessa perspectiva, o público-alvo das pesquisas, as estratégias didáticas, as revistas e as principais temáticas. Pode-se destacar que um entrelaçamento do tema com atividades investigativas e sequências de ensino e aprendizagem e argumentação estão presentes na maioria dos trabalhos, ocorrendo principalmente no Ensino Fundamental. Houve também a identificação das principais práticas epistêmicas mencionadas nos artigos. Reforça-se que há bastante espaço para o estudo do tema tanto na Educação Básica quanto no Ensino Superior, além da necessidade de se entender a construção epistemológica do STEAM/STEM para se aplicar às práticas epistêmicas de cada disciplina e que estas não sejam perdidas no processo de interdisciplinaridade.
PERCEPÇÃO DE PROFESSORES DA EDUCAÇÃO BÁSICA PÚBLICA DO ESTADO DE MATO GROSSO SOBRE OS DESAFIOS DA EDUCAÇÃO INCLUSIVA E DO NOVO ENSINO MÉDIO
Authors: Pachceo Zaryf Araji Dahroug , Hardoim Edna Lopes
Published: June 2024

Vários professores enfrentam desafios em sala de aula, que são resultantes, muitas vezes, da inadequada formação para lidar com tal realidade. O objetivo dessa pesquisa foi verificar a percepção e as principais dificuldades dos professores que atuam na educação básica pública do estado de Mato Grosso sobre a educação inclusiva e o Novo Ensino Médio (NEM). Professores colaboradores foram convidados a responder um questionário on-line, visando detectar o seu nível de confiança para atuar na educação inclusiva e nas diretrizes do NEM. Contamos com a colaboração de 62 docentes, a maioria do sexo feminino, entre 38 e 48 anos, com tempo de docência entre 11 e 15 anos. Numa escala crescente de 1 a 5, os professores, na sua maioria, consideraram o seu nível de confiança em atuar na educação inclusiva como 2 e 3 no NEM. Os colaboradores elencaram a falta de formação continuada como principal causa para suas dificuldades e registraram 7 demandas de temáticas da área das Ciências da Natureza e suas Tecnologias. Concluímos que os professores possuem grandes desafios e que consideram a formação continuada como aliada para o alcance do sucesso docente em sala de aula.
Analisis dan Visualisasi Periodisitas Gempa Bumi di Maluku Utara
Authors: Arfiani Ika , Normawati Dwi , Suratin Muhammad Dzikrullah
Published: June 2024

Gempa bumi juga dapat dipahami sebagai suatu peristiwa terjadinya guncangan bumi akibat pelepasan energi secara tiba-tiba, yang ditandai dengan pecahnya lapisan batuan pada kerak bumi. Gempa bumi biasanya disebabkan oleh pergerakan kerak atau lempeng bumi. Indonesia termasuk negara rawan gempa karena Indonesia dilalui pertemuan 3 lempeng tektonik: Indo-Australia, Eurasia, dan Pasifik. Beberapa penelitian tentang gempa bumi di Indonesia telah menghubungkan gempa bumi dengan data mining dan pembelajaran mesin. Namun gempa bumi merupakan peristiwa alam yang tidak dapat diprediksi atau diprediksi, sehingga untuk mengurangi risiko terjadinya gempa bumi perlu dilakukan analisis clustering pada daerah yang dicurigai. Kontribusi dalam penelitian ini bertujuan untuk memvisualisasikan data hasil pengolahan dataset gempa bumi kedalam peta geospasial wilayah Maluku Utara dengan menerapkan tahapan data mining, sehingga bisa mengetahui daftar wilayah yang termasuk dalam kawasan rawan bencana sebagai langkah antisipasi untuk mitigasi bencana di daerah Maluku Utara. Selain itu hasil penelitian ini juga dapat digunakan sebagai dataset untuk melakukan proses data mining lain seperti pengelompokan maupun klasisfikasi data gempa bumi di wilayah Maluku Utara.
Politik Islam dalam Konteks Tunisia Pasca Revolusi Jasmine: Analisis Pemikiran Rashid Ghannoushi Political Islam in The Post-Jasmine Revolution Context of Tunisia: Analyzing the Thoughts of Rashid Ghannoushi
Authors: A. Rahman M.Zaidi , Tumin Makmor , Abidin Azmil Zainal
Published: June 2024

Tunisia has a unique experience as the first Arab country to spark the Arab Spring. This uprising was filled with a series of anti-government protests called the Jasmine Revolution. In that situation, Rashid Ghannoushi, the head of the Islamic Movement in Tunisia (Al-Nahdah) was also involved in the situation by putting his perspective based on the party’s Islamic agenda. So, the objective of this article is to trace the political thought of Rashid Ghannoushi in achieving political goals through the framework of Islamic politics. This is because the results of his thought on political Islam show a significant difference with other Islamic movements especially in the context of managing power sharing. The results of the study found that his political views take into account local factors such as autocratic leadership and the secular doctrine of laicite, that inspired him to consider between the ideal of Islamic doctrine and the realistic of the atmosphere and situation in Tunisia.
Revisiting Social Justice: Exploring the Qur’anic Paradigm in Addressing Contemporary Challenges
Authors: Junaidi Juliyana , Abdul Majid Latifah , Nazri Mohd Arif
Published: June 2024

Freedom, equality, and fraternity serve as fundamental pillars within discussions on social justice, yet in the contemporary era, these principles have been greatly undermined, leading to increased social injustice within the realms of social, politics and economics. One contributing factor to this phenomenon is the predominant reliance on secular approaches to address social justice issues, neglecting the potential role of divine guidance found in the Qur’an. Despite being a comprehensive reference encompassing principle of social justice, the Qur’an has been largely overlooked as a source for solutions in the modern era. Therefore, this article aims to examine the Qur’anic paradigm of social justice that hold the potential to address the social justice challenges prevalent in the modern generation. This qualitative study employs content analysis as a primary methodology, supplemented by descriptive and thematic analysis to present the gathered data. Initially, social justice issues are identified, followed by an analysis of relevant Qur’anic verses using Qur’anic commentary books and related sources. The findings highlight fifteen Qur’anic verses that are intricately linked to the principles of social justice within the Qur’an, including the dignified ranking of humanity, freedom of humanity, equitable distribution of wealth and opportunities, and the respect for human rights.
The Relevance of Contemporary Epistemology on Existing Knowledge: A Critical Analysis of Western Scientific Worldview according to al-Attas Perspective
Authors: Arroisi Jarman , Zarkasyi Hamid Fahmy , Roini Winda
Published: June 2024

The progress of modern science and technology is considered very significant and provides convenience in every aspect. However, science has become the biggest challenge because it requires relevance to religion. The disparity between science and religion creates a dilemma, resulting in the secularization of science. This study aims to critically analyze the epistemology of Western science from the perspective of Al-Attas, which is specifically considered problematic by him. The method used in this research was content analysis, while the approach used was a critical approach. The results of this study prove that the paradigm of science is closely related to worldview. This proves that modern science and technology are not neutral and devoid of values, including religion. This has an impact on changing the way humans view and think about science and life, resulting in the deconsecration of value, desacralization, and disenchantment of nature. To map out the epistemological and Western worldview problems, al-Attas offers the Islamization of contemporary science and the epistemology of Islamic science to answer the problem of the existence of contemporary science epistemology.
Tratamento pulpar em dentes permanentes jovens
Authors:   , Roque Giovanna Cavalcante , Colchiesqui Isabela Casemiro , Patricio Nathália Borborema de Jesus , Corrêa Sabrina Pereira Bueno
Published: June 2024

Rizogênese é o processo de formação da raiz do dente, geralmente nos dentes permanentes jovens esse processo ainda está ocorrendo, e a raiz encontra-se incompletamente formada. A endodontia em dentes permanentes jovens tem como objetivo manter um ambiente pulpar que permita a apicogênese por meio da eliminação dos agentes injuriantes à polpa. Dentes com rizogênese incompleta podem enfrentar diversos problemas durante o tratamento, inúmeras vezes o canal não é higienizado completamente, devido anatomia com divergência apical e paredes dentinárias pouco espessas além da presença de um canal amplo, pode ocorrer lesões perirradiculares por conta de uma ausência de barreira apical, a qual impossibilita a acomodação do material obturador apenas dentro do canal, limitando assim a desinfecção e a modelagem dos canais. O objetivo desse artigo é apresentar através de uma revisão de literatura o diagnóstico pulpar em dentes com rizogênese incompleta, os tratamentos indicados para cada diagnóstico, alternativas de materiais e possíveis complicações do tratamento. Concluiu-se que é de suma importância realizar o correto diagnóstico pulpar destes elementos afim de escolher o tratamento mais indicado e de evitar a perda dental prematura.
PANEL DATA REGRESSION ANALYSIS FOR MODELING THE HUMAN DEVELOPMENT INDEX IN NORTH SULAWESI PROVINCE
Authors: Abdussamad Siti Nurmardia , Adityaningrum Amanda , Payu Muhammad Rezky Friesta
Published: June 2024

The regression analysis is a technique used in hypothesis testing to determine the impact of one variable on another. This study uses Panel Data Regression Analysis, which combines cross-sectional and time series data. This study aims to analyze the impact of Life Expectancy, Income Per Capita, Expected School Years, and Average School Years on the Human Development Index. According to the result of the analysis, the Common Effect Model (CEM), which used Ordinary Least Squares (OLS) estimation, was the most suitable model. The equation obtained is . Moreover, according to the significance test, all independent variables were significantly related to the dependent variable
Nilai Energi dan Kadar Zat Gizi pada Formulasi Omelet Berbasis Ikan Kakap Merah dan Wortel
Authors: Fitrasyah Siti Ika , Mellyni Tutri Aprilia , Putri Linda Ayu Rizka , Rahman Nurdin , Tangkas I Made , Ariani Ariani , Aiman Ummu , Nurulfuadi Nurulfuadi , Nadila Devi
Published: June 2024

Pemberian Makan Bayi dan Anak merupakan kunci untuk meningkatkan kelangsungan hidup anak dan meningkatkan pertumbuhan dan perkembangan yang sehat. Dua tahun pertama kehidupan seorang anak sangat penting, karena zat gizi yang optimal selama periode ini menurunkan penyakit dan mengurangi risiko kematian, dan mendorong perkembangan yang lebih baik secara keseluruhan. Tujuan penelitian ini adalah untuk menganalisis nilai energi dan kadar zat gizi (karbohidrat, protein, lemak, kalsium, dan β -karoten); daya terima; serving size pada formula omelet berbasis ikan kakap merah dan wortel. Jenis penelitian yang digunakan adalah metode eksperimen dengan melakukan percobaan pengolahan formula bahan makanan dari bahan baku telur, ikan kakap merah dan wortel. Desain penelitian analisis zat gizi adalah penelitian deskriptif berbasis uji laboratorium. Sementara itu, desain penelitian yang digunakan pada analisis daya terima adalah uji hedonik organoleptik. Penelitian dilaksanakan di Laboratorium Kimia Analitik, FMIPA dan Gedung FKM, Universitas Tadulako. Penelitian ini dilaksanakan pada bulan Desember 2021 hingga Januari 2022. Analisis kadar karbohidrat menggunakan metode Anthrone, kadar lemak menggunakan metode Soxhletasi, kadar protein dan betakaroten menggunakan metode UV-Vis, dan kadar kalsium menggunakan metode SSA. Analisis data menggunakan analisis One Way ANOVA dan Kruskal-Wallis. Berdasarkan hasil penelitian, semua formula melebihi ± 10% nilai energi; kadar protein; kadar lemak; dan kadar β-Karoten rujukan. Namun, semua formula berada di bawah ± 10% kadar karbohidrat. Sementara itu, F0 dan F1 di bawah ± 10% kadar kalsium rujukan, dan F2-F4 melebihi ± 10% kadar kalsium rujukan. Formula terpilih untuk penentuan serving size lebih lanjut adalah F3. Serving size untuk omelet berbasis ikan kakap merah dan wortel adalah sebesar 50 g. Sebagai kesimpulan, formulasi omelet dengan penambahan ikan kakap merah dan wortel dapat dijadikan sebagai menu selingan alternatif untuk pencegahan kekurangan gizi pada bayi 6-11 bulan.
Hubungan Obesitas dengan Kejadian Hipertensi dan Hiperglikemia di Indonesia
Authors: Badriyah Lulu'ul , Pratiwi Retno Inten Rizqi
Published: June 2024

Berat badan berlebih akan memicu meningkatkan kadar hormon leptin dalam tubuh. Leptin berperan dalam resistensi insulin dengan mengganggu penyerapan glukosa sehingga meningkatkan kadar gula darah. Selain itu, berat badan berlebih juga memicu peningkatan aktivitas saraf simpatis, resistensi insulin, dan peningkatan aktivitas sistem renin-angiotensin di ginjal yang berkontribusi terhadap hipertensi. Tujuan penelitian ini adalah untuk mengetahui hubungan obesitas dengan kejadian hipertensi dan hiperglikemia di Indonesia. Penelitian ini menggunakan survei nasional Riskesdas 2018  yang memiliki desain studi cross-sectional. Pengambilan sampel Riskesdas tahun 2018 yang dilakukan pada bulan Maret 2018. Sasaran sampelnya adalah 300.000 rumah tangga di 30.000 blok sensus (BS) Susenas dengan metode PPS (probability proportional to size) menggunakan linear systematic sampling dengan two stage sampling. Populasi dalam penelitian adalah seluruh individu berusia 25-45 tahun di Indonesia. Jumlah sampel awal penelitian adalah 305.457 responden dan setelah dilakukan cleaning data,  sampel yang memiliki kelengkapan data ada 9.954 responden. Selanjutnya, data dianalisis secara univariat dan bivariat. Analisis bivariat dilakukan menggunakan uji chi-square. Hasil penelitian  menunjukkan 44,9% responden  mengalami obesitas, 34,0% menderita hipertensi, dan 4,6% mengalami hiperglikemia. Terdapat hubungan yang bermakna antara obesitas dengan kejadian hipertensi (p=0,001) Responden yang kelebihan berat badan memiliki kemungkinan 2,73 kali lebih besar untuk menderita hipertensi dibandingkan responden dengan gizi normal (OR 2,73 2,51–2,97). Terdapat hubungan yang bermakna antara obesitas dengan hiperglikemia (p=0,001). Responden yang mengalami obesitas memiliki kemungkinan 1,89 kali lebih besar untuk mengalami hiperglikemia dibandingkan responden dengan gizi normal (OR 1,89 1,57-2,30). Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat hubungan obesitas dengan kejadian hipertensi dan hiperglikemia.
Preparación para el cuidado en cuidadores de enfermos crónicos y sus factores relacionados
Authors: Guerrero-Gaviria Daniel , Carreño-Moreno Sonia , Chaparro-Díaz Lorena
Published: June 2024

Introduction: Chronic non-communicable diseases present a burden to care systems world- wide. Family caregivers assume this burden abruptly and without the necessary preparation, so they are prone to overload due to this and other factors. The preparedness caregiving scale has been validated in other contexts and has shown reliable psychometric properties to measure preparation in family caregivers. There are other variables, in addition to prepared- ness, that influence the caregiver burden, so it is necessary to carry out studies that measure the relationship between variables. Objective: To determine the relationship between care- giving preparedness, sociodemographic and care variables with caregiver burden in fami- ly caregivers of people with chronic non-communicable disease. Materials and methods: Quantitative, cross-sectional, analytical study carried out in Bogotá, Colombia in the second semester of 2022. Results: The variables of caregiver age, time as caregiver, and daily hours dedicated to care activities demonstrated to be statistically significant in their relationship with caregiver burden and caregiving preparedness. Discussion: Measuring caregiving pre- paredness serves as a basis to produce interventions based on the needs in the formation of practical skills for performance as a caregiver. Improving the preparation of caregivers can reduce the overload and the implications that it brings.
AN EVALUATION OF THE COOKING VESSELS UNEARTHED IN THE TOPAKLI HÖYÜK EXCAVATIONS (1967-1974)
Authors: Gökçe Emine
Published: June 2024

Excavations were carried out in Topaklı Höyük by L. Polacco between 1967 and 1974. During these studies, pottery and teapots used in cooking from layer L to layer C were unearthed. Pots recovered from different layers stand out with their common shape features (rims protruding, having a neck, round body, flat bottom, and handle attached between the neck and body).
The soot/burn marks observed on the pots support the idea that these pots were used for cooking. Topaklı Höyük pots have different capacities. Small-sized ones may be related to the number of people in the house or used for making sauce, while larger ones may be related to the number of people in the house or the cooked product (such as milk). A teapot used for cooking on the stove was also found in Topaklı Höyük. This vessel, like the pots, has a flared rim, a round body, a flat bottom, a spout, and a single strip handle attached between the rim and the body.
The cooking pots found in the Topaklı Höyük settlement had been frequently used in the Kızılırmak Basin. Encountered in all settlements in the region, these pots continued to be used without any change in form over a wide period, from the 7th century BCE to the 1st century BCE. The form called the teapot is a continuation of the form known from the Hittite Imperial Period in the Kızılırmak Basin.
ALANYA GELENEKSEL KONUTLARININ SOKAK UZANTILARI, ÇIKMALAR ÜZERİNE TOPOLOJİK BİR DEĞERLENDİRME
Authors: Yılmaz Erkovan Nisa , Özgenel Lale
Published: June 2024

Alanya geleneksel konut dokusu Cilvarda burnunun tanımladığı yarımadada bulunan kale içerisindedir. Bu çalışma kale surları içerisindeki geleneksel yerleşime odaklamakta, iç ve dış mekân arasında bir arakesit mekân olan konut çıkmalarının tektonik kurgusu ve mimari anlamı üzerine, sokak dokusu-konum ilişkisi, yapılar arası ilişki ve yapı içi mekânsal kurgu üzerinden bir okuma sunmayı amaçlamaktadır. Literatür taraması ve arazi çalışmaları ile desteklenen çalışmada kale surları içinde toplam 22 adet konut yerinde incelenmiş, sahipleri ile görüşmeler yapılarak, yapım ve kullanımları hakkında bilgi derlenmiştir. Bu örnekler referansında birbiriyle ilişkilenen iki tartışma okumanın çerçevesini oluşturmaktadır, geleneksel çevrelerin şekillenişinde, yapı ve mekân oluşumlarında iklim, arazi yapılanması, malzeme, ekonomik durum ve kültürel yapılanma etkenlerinin rolü, yapıların biçimlenme özellikleri sonucu oluşan konut mekanlarının ve mekanlar arası ilişkilerin kurgulanma özellikleri. Evin ve sokağın bir parçası olan çıkmaların tektonik kurgusu ve aralarındaki ilişkiler, geleneksel yapılı çevreyi bütüncül bir yaklaşımla ele alan bu çerçeve içinde değerlendirilmiştir. Bu anlamda, çalışma çıkmalar üzerine bir tipoloji çalışması değil, biçimsel ve mimari nitelikler ve ilişkilerin irdelendiği bir topoloji çalışmasıdır
KONYA/HÜYÜK BUDAK KÖYÜNDEKİ KÖY ODALARININ MEKÂNSAL VE KÜLTÜREL AÇIDAN İNCELENMESİ
Authors: Uslu Bülbül Zehra
Published: June 2024

Anadolu’nun pek çok yerinde bulunan ancak terk edilmeye başlamış olan köy odaları, Türk toplumunun en belirgin özelliklerinden olan konukseverliğini, yardım sever, paylaşımcı özelliğini, dayanışma, saygı, sevgi ve hoşgörünün önemini ve bu değerlerin sanatla birleşerek mimariye tezahürünü insanlığa sunan kültürel yapılardır. Anadolu’nun bazı yerlerinde köy odaları, sanat değeri taşıyan mimarileri ve köy odası kültürüyle korunabilmiş kültür varlıklarıdır. Bunlar hem mimari anlamda kültür varlıkları olup, hem de somut olmayan kültürel mirasın korunduğu ve yaşatıldığı yapılardır. Bazı bölgelerde ise somut olmayan kültürel miras özelliği taşıyan köy odası geleneği ve kültürü yeni yapılmış, tarihi değeri olmayan binalar içerisinde yaşatılmaktadır. Çoğu yerde ise köy odası kültürü tamamen kaybolmuştur. Konya’nın Hüyük ilçesi civarında köy odası geleneği ve kültürünün yeni binalarda yaşatıldığı ve sürdürülebildiği Budak köyü, bu açıdan önemlidir. Budak köyündeki köy odaları, misafirhane/konukevi özelliklerini barındırmalarının yanı sıra Ramazan Bayramlarında köy odasında buluşma ve bayramlaşma merasimiyle önem arz etmektedir. Çalışma kapsamında, Budak köyündeki köy odası geleneği ve kültürü, hem sosyo-kültürel ve tarihi bakımdan hem de mekânsal açıdan analiz edilmiştir. Literatür araştırması, köy odalarının ölçümü ve planlarının çizimi, köy odalarının yerinde incelenmesi, arazi çalışması, köy odası geleneğinin deneyimlenmesi ve yapıyla ilgili şahıslarla sözlü görüşmeler yapılması çalışmada kullanılan başlıca yöntemlerdir. Bu çalışma ile Türk toplum yapısını ve kültürünü yansıtan Budak köyündeki köy odası geleneği ve kültürünün gelecek nesillere aktarılmasına katkı sağlamak amaçlanmaktadır.
Dating of oak timbers from Anadolu Hisarı (Anatolian Fortress), İstanbul-Türkiye
Authors: Akkemik Ünal , Özarslan Yasemin , Wazny Tomasz
Published: June 2024

Anadolu Hisarı, or the Anatolian Fortress, is a prominent historic building located on the Anatolian side of Bosphorus, Istanbul, right across the well-known Rumeli Hisarı (the Rumeli Fortress). The fortress is known to have been built during the reign of the Ottoman Sultan, Yıldırım Bayezid, in 1395. In 2022 during the restoration of the fortress we collected a group of stem discs from six timbers stored in its garden for dendrochronological dating. The timbers were dated to 1395 after standard dendrochronological methods were applied. This result is consistent with the completion dates of the construction, 1395-1396, mentioned in historical records. The part of the walls from which the sampled timbers had been removed are from the original construction and were replaced during the recent restoration work. Our study shows that identifying the exact context of architectural wood removed during restoration of such historical buildings in Istanbul can help identify their original parts and the time of restoration activities that may have taken place in the past.
PP2A dependent and independent effects of forskolin in KMT2A (MLL)-rearranged acute leukaemia
Authors: Arroyo-Berdugo Yoana , Mambro Antonella Di , Behrends Volker , Sahai Michelle , Cozzuto Luca , Zollo Immacolata , Ponomarenko Julia , Williams Owen , Gribben John , Calle Yolanda , Patel Bela , Esposito Maria Teresa
Published: June 2024

Background and purpose Activation of Protein Phosphatase 2A (PP2A), via
genetic and pharmacologic modulation of SET, has recently being
identified as a promising strategy to therapeutically target acute
myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations
(KMT2A-r AML). In this study we investigated the expression of PP2A
subunits and the therapeutic potential of forskolin, a cAMP elevating
natural compound reported as a PP2A activator. Key results Our data show
that PPP2CA is abundantly expressed in KMT2A-r AML cells. Treatment with
forskolin arrests proliferation, induces cell death, represses the
expression of MYC, HOXA9 and HOXA10 and attenuates the activity of
ERK1/2 in KMT2A-r AML cells. Forskolin increases sensitivity to
standard-of-care daunorubicin in KMT2A- AML cell lines and PDX.
Silencing PPP2CA partially rescues the cytotoxic effect of forskolin,
stimulates ERK1/2, inhibits GSK3β, abolishes the forskolin-mediated
repression of MYC, but it did not affect the potentiation of response to
daunorubicin. This effect was also not dependent on increase of cAMP,
but it was due to increase in the intracellular accumulation of
daunorubicin, through inhibition of drug efflux pump P-glycoprotein 1
(multidrug resistance protein). Conclusions and implications In
conclusion, our findings highlight a novel mechanism of action for
forskolin and support a potential role of this natural compound in
combination with current conventional agent daunorubicin in the
treatment of KMT2A-r A
Extraction of 6-year-old leadless pacemaker (MICRA) using commercially available removal tools- case report.
Authors: Chmielewska-Michalak Lidia , Gwizdała Adrian , Ciepłucha Aleksandra , Katarzyńska-Szymańska Agnieszka , Ochotny Romuald , Lesiak Maciej , Mitkowski Przemysław
Published: June 2024

In recent years, the number of patients with implanted leadless
pacemaker has increased significantly. Due to the small size of the
device, low risk of infection, indications for removal are rare. The
dwell time is correlated with extraction difficulty. Although the MICRA
TPS contains retrieval feature at the proximal part of the device, the
manufacturer (Medtronic) does not offer tools dedicated to this
procedure. Complete encapsulation of the device may also make removal
difficult or even impossible. We present the case of a patient in whom
MICRA TPS was successfully removed 70 months after implantation with
non-dedicated commercially available tools.
Performance of the ChatGPT Large Language Model for Decision Support in Community Pharmacy
Authors: Shin Euibeom , Hartman Maggie , Ramanathan Murali
Published: June 2024

Purpose: To assess the ChatGPT-4 (ChatGPT) large language model (LLM) on
tasks relevant to community pharmacy. Methods: ChatGPT was assessed with
community pharmacy-relevant test cases involving drug information
retrieval, identifying labeling errors, prescription interpretation,
decision making under uncertainty and multi-disciplinary consults. Drug
information on rituximab, warfarin, and St. John’s wort was queried. The
decision-support scenarios consisted of a subject with swollen eyelids,
and a maculopapular rash in a subject on lisinopril and ferrous sulfate.
The multi-disciplinary scenarios required integration of medication
management with nutrition and physical therapy. Results: The responses
from ChatGPT-4 for rituximab, warfarin, and St. John’s wort were
satisfactory and cited drug databases and drug-specific monographs.
ChatGPT identified labeling errors related to incorrect medication
strength, form, administration route, unit conversion, and directions.
For the patient with inflamed eyelids, the course of action developed by
GPT-4 was comparable to the pharmacist’s approach. For the patient with
the maculopapular rash, both the pharmacist and ChatGPT placed a drug
reaction to either lisinopril or ferrous sulfate at the top of the
differential. ChatGPT provided customized vaccination requirements for
travel to Brazil, guidance on management of drug allergies, and recovery
from a knee injury. ChatGPT provided satisfactory medication management
and wellness information for a diabetic on metformin and semaglutide.
Conclusions: LLMs have the potential to become a powerful tool in
community pharmacy. However, testing in validation studies across
diverse pharmacist queries, drug classes, and populations, and
engineering to secure patient privacy will be needed to enhance LLM
utility.
Measurement and simulation of hydrodynamics and mixing time in stirred tank with submerged long-short blades impeller
Authors: WU Yongjun , Lin Yong , Luo Peicheng
Published: June 2024

The hydrodynamics and mixing characteristics of long-short blades (LSB)
impeller have been investigated by particle image velocity (PIV), planar
laser induced fluorescence (PLIF) and large eddy simulation (LES). The
prediction accuracy of LES was assessed by the velocity distribution,
tracer concentration distribution and power number. The results
demonstrate that there are few stagnation zone and no zone effect in LSB
stirred tank. The special design of LSB impeller leads to the up-flow in
the lower region and down-flow in the upper region, which makes the
pumping number of LSB impeller is better than that of single RT and dual
RTs. In addition, the feed location and detecting location do not affect
the homogeneity of the local mixing process, that is, the tracer
diffuses rapidly to the whole tank in the axial and radial directions.
The dimensionless mixing time correlation equation of LSB impeller is
established.
The critical mass ratio for W UMa-type contact binary systems
Authors: Arbutina Bojan , Wadhwa Surjit
Published: June 2024

Contact binaries are close binary systems in which both components fill their
inner Roche lobes so that the stars are in direct contact, and in potential
mass and energy exchange. The most common such systems of low mass are the
so-called W UMa-type. In the last few years, there has been a growing
interest of the astronomical community in stellar mergers, primarily due to
the detection of gravitational waves (mergers of black holes and neutron
stars), but also because of an alternative model for the type Ia supernovae
(merger of two white dwarfs), which are again particularly important in
cosmology where they played a significant role in the discovery of dark
energy and the accelerated expansion of the Universe. In that sense, contact
systems of W UMa type with extremely low mass ratio are especially
interesting because there are indications that, in their case too, stars can
merge and possibly form fast-rotating stars such as FC Com stars and the
blue-stragglers, and (luminous) red novae such as V1309 Sco. Namely, the
previous theoretical research has shown that in the cases when the orbital
angular momentum of the system is only about three times larger than the
rotational angular momentum of the primary, a tidal Darwin's instability
occurs, the components can no longer remain in synchronous rotation, orbit
continue to shrink fast, and they finally merge into a single star. The above
stability condition for contact systems can be linked to a specific critical
mass ratio below which we expect a system to be unstable. We give an
overview of this condition and show how it can be used to identify potential
mergers. Finally, we discuss a number of known extreme mass ratio binaries
from the literature and consider prospects for future research on this
topic.
Effect of 48 Months of Closed-Loop Insulin Delivery on Residual C-Peptide Secretion and Glycemic Control in Newly Diagnosed Youth With Type 1 Diabetes: A Randomized Trial
Authors: Ware Julia , Boughton Charlotte K. , Allen Janet M. , Wilinska Malgorzata E. , Hartnell Sara , Thankamony Ajay , Randell Tabitha , Ghatak Atrayee , Besser Rachel E.J. , Elleri Daniela , Trevelyan Nicola , Campbell Fiona M. , Sibayan Judy , Bailey Ryan , Calhoun Peter , Dunseath Gareth , Hovorka Roman ,   CLOuD Consortium, Randell Tabitha , Verhoeven Vreni , Hovorka Roman , Thankmonay Ajay , Acerini Carlo , Dunger David , Boughton Charlotte , Ware Julia , Tauschmann Martin , Lakshman Rama , Allen Janet , Wilinska Malgorzata , Hartnell Sara , Cezar Alina , Ashcroft Nicole , de Barros Tamarozzi Mirela , Murthy Meena , Ghatak Atrayee , Thornborough Keith , Mimnagh Jonathon , Shakeshaft Joanne , Phelan Karen , Besser Rachel , Law Rebecca , Megson Clare , Haest Jane , West Alison , Stamford Imogen , Elleri Daniela , McDonald Morag , Trevelyan Nicola , Dewar Helen , Brampton Rachel , Price Gabrielle , Crouch Gillian , Campbell Fiona , Yong James , Metcalfe Emily , Cameron Andrew , Lawton Julia , Rankin David , Sibayan Judy , Calhoun Peter , Bailey Ryan , Rusnak Jessica , Bugielski Brian , Dunseath Gareth , Luzio Stephen , Northam Elisabeth , Todd John , Roze Stéphane , Scott Eleanor , Jones Tim , Patterson Chris , Adolfsson Peter , Gregory John , Greene Stephen , Blair Jo , Passmore Alexia
Published: June 2024

OBJECTIVE

We evaluated the effect of long-term intensive metabolic control with hybrid closed-loop (CL) on residual C-peptide secretion and glucose control compared with standard insulin therapy in youth with type 1 diabetes over 48 months.

RESEARCH DESIGN AND METHODS

Following the 24-month primary phase of a multicenter, randomized, parallel trial of 96 newly diagnosed youth aged 10 to 16.9 years, participants were invited to an extension phase using treatment allocated at randomization. They continued with hybrid CL using the Cambridge algorithm or standard insulin therapy (control) until 48 months after diagnosis. Analysis was by intention-to-treat.

RESULTS

At 24 months after diagnosis, 81 participants (mean ± SD age 14 ± 2 years) continued in the extension phase (47 CL, 34 control). There was no difference in fasting C-peptide corrected for fasting glucose at 48 months between groups (CL: 5 ± 9 vs. control: 6 ± 14 pmol/L per mmol/L; mean adjusted difference −2 [95% CI −7, 4; P = 0.54]). Central laboratory HbA1c remained lower in the CL group by 0.9% (10 mmol/mol [95% CI 0.2, 1.5; 3, 17 mmol/mol); P = 0.009). Time in target range of 3.9 to 10.0 mmol/L was 12 percentage points (95% CI 3, 20; P = 0.008) higher in the CL group compared with control. There were 11 severe hypoglycemic events (6 CL, 5 control) and 7 diabetic ketoacidosis events (3 CL, 4 control) during the extension phase.

CONCLUSIONS

Improved glycemic control was sustained over 48 months after diagnosis with CL insulin delivery compared with standard therapy in youth with type 1 diabetes. This did not appear to confer a protective effect on residual C-peptide secretion.
A 3D-s fémnyomtatás, mint a gépjárműmotorok gyártásának ígéretes jövőbeni technológiája
Authors: Ficsor Botond
Published: June 2024

A belső égésű hőerőgép ma már általánosan elterjedt, hétköznapi eszköz. A 3D-s fémnyomtatás egyre nagyobb sebességgel terjedő és fejlődő gyártástechnológia. Számos járműipari vállalat foglalkozik 3D-s fémnyomtatott alkatrészek előállításával, amelyeket belső égésű hőerőgépekbe szerelnek és tesztelnek, hiszen jelentős előnnyel jár az ezen technológiával előállított alkatrészek alkalmazása. A fémnyomtatással előállított alkatrészek tesztelésének pozitív eredményei miatt, a különböző polgári járműipari cégek teszteléseinek eredményei katonai szempontból is jelentősek. A szerző a nemzetközi példák említését követően ismerteti a Széchenyi István Egyetem hallgatóinak és az Audi Hungaria mérnökeinek együttműködésében megvalósuló 3D-s nyomtatott motor fejlesztési projektjét.
A magyar Phönix C.I-es repülőgépek története 1. rész
Authors: Hajdu Péter
Published: June 2024

Az I. világháború végén, az osztrák tervezésű Phönix C.I-es kétüléses felderítő és általános célú kétfedelű repülőgép korának egyik legjobb gyorsfelderítője volt. A nagy háborút követően néhány ország légiereje még tovább üzemeltette különböző változatait, így a gép aktív részese volt a háborút követő konfliktusoknak is. A Phönix C.I-esek építése Magyarországon is elkezdődött (az aszódi Magyar Lloyd Repülőgép és Motorgyár Rt. 1919 első felében kezdte meg a gyártását). A már leszállított példányokat az újonnan kikiáltott köztársaság, később a Tanácsköztársaság és a Nemzeti Hadsereg is használta hazánkban. A szerző cikksorozatában az eddig csak szűk szakmai körben publikált dokumentumok és források alapján ismerteti a Magyarországon repült Phönix C.I-esek alkalmazásának történetét.
Detection of some β-lactamase Genes in Klebsiella pneumoniae Isolated from some Baghdad Hospitals, Iraq
Authors: Hussein ALI Y. , Abdulsattar Ban O. , Al-Saryi Nadal A. , Edrees Wadhah H.
Published: June 2024

Background: Multi-Drug-Resistant Klebsiella pneumoniae (MDR K. pneumoniae) is considered as an important opportunistic pathogen, which causes life threatening infections. K. pneumoniae is known to causes life-threatening infections. Objective: The objective of this study is to detect some β-lactamase genes inKlebsiella pneumoniae. Methods: Thirty-five K. pneumoniae isolates were obtained from some hospitals in Baghdad City between October 2022 and February 2023. The identification of K. pneumoniae isolates was done phenotypically by the automated VITEK II system and genotypically by amplification of the rpob gene. The antibiotic susceptibility and detection of some β-lactamase genes were tested for all isolates. Results: The results showed that the K. pneumoniae isolates were resistant to most antibiotics used. A high percentage of K. pneumoniae isolates were resistant to cefixime, cefpodoxime, norfloxacin and doxycycline as 100% followed by ceftriaxone, ceftazidime, ticarcillin/clavulanate, ticarcillin, ceftazidime, tobramycin, and moxifloxacin (97.2%, 91.7%, 91.7%, 94.4%, 94.4%, and 94.4%, respectively). Furthermore, approximately 94.4% of the isolates were MDR. In addition, the molecular methods only detected the blaNDM and blaT EM genes as 33.3% and 75.6% of in the K. pneumoniae isolates, respectively, while the blaV IM, blaCTX−M, and blaKP C genes were not observed in K. pneumoniae isolates. Conclusions: β-lactam antibiotics, including carbapenems, are widely used to treat bacterial infections; however, an increase in antibiotic resistance due to β-lactamases limits the effectiveness of these antibiotics. Therefore, alternative treatment methods are required to control these resistant isolates.
DeepRing: Convolution Neural Network based on Blockchain Technology
Authors: Mousa Sura Hamed , Shati Narjis Mezaal , Sakthivadivel Nageswari
Published: June 2024

Background: This paper addresses specific challenges in predictive modeling, namely transparency issues, susceptibility to data manipulation, and fairness concerns. To overcome these obstacles, the study introduces DeepRing, approach that combines Convolutional Neural Networks (CNNs) and blockchain technology. Objective: DeepRing aims to enhance prediction integrity, data security, and fairness, thereby improving the ethical considerations, reliability, and accountability of predictive models. Methods: involves iterative training of a CNN model on five diverse datasets, including CIFAR-10, Fashion-MNIST, MNIST, CIFAR-100, and a Hands dataset. The CNN architecture incorporates Conv2D layers, MaxPooling2D layers, and Dense layers. Training metrics such as accuracy and sparse categorical cross-entropy loss are monitored, with the Adam optimizer employed. While achieving high accuracy on Plam (0.5300), MNIST (0.9978) and Fashion MNIST (0.9673), DeepRing exhibits moderate performance on CIFAR-10 (0.9296) and lower accuracy on CIFAR-100 (0.5973). Results: demonstrate the effectiveness of DeepRing in improving accuracy and enhancing model performance across various datasets. However, further development and validation are essential for successful model implementation, further development and validation are essential for successful model implementation. Conclusions: Introduces DeepRing as an innovative solution to address key challenges in predictive modeling, specifically focusing on transparency issues, susceptibility to data manipulation, and fairness concerns. By combining Convolutional Neural Networks (CNNs) with blockchain technology, DeepRing aims to elevate prediction integrity, enhance data security, and promote fairness, thereby contributing to the improvement of ethical considerations, reliability, and accountability in predictive modelling.
Topical Polyethylene Glycol-Phage Ointment as a Therapy to Treat Burn-Wound Infection Using Mice Model
Authors: Mansoor Karrar Jabbar , Kaabi Sadeq Abdulridha Gatea
Published: June 2024

Background: One of the most significant problems facing public health today is antimicrobial resistance. Pseudomonas aeruginosa is considered one of the most prevalent causes of healthcare-associated illnesses. Objective: The use of phages as a potential alternative therapeutic method for treating bacterial infections has been the subject of significant research to solve this predicament. Methods: The P. aeruginosa isolates that caused infections of burn wounds were collected from three hospitals in Baghdad. The VITEK system diagnosed and examined the isolates for their antibiotic sensitivity. As well as the phages were isolated and purified from sewage water samples from different sewer stations. After these steps, phages were examined by transmission electron microscopy to ensure the order and the families of these phages, and the tests of lytic activities of phages on the P. aeruginosa isolates were done to determine the best lytic ability of them to use for treatment wounds infections. Results: Burn-wound infections swabs culture showed a positive culture for 109 isolates as the following P. aeruginosa in 76(69.72%), Staphylococcus aureus16(14.67%), Acinetobacter baumannii 9(8.25%), Klebsiella pneumoniae 5(4.58%), Escherichia .coli 3(2.75%) obtained from burn wound infections, had a significant level of resistance to several antibiotics. Four bacteriophages were isolated: KM1, KM2, KM3, KM4 and KM5. KM5 is a mixture of phages referred to as a cocktail. The four phages and their cocktail exhibited significant lytic activity against P. aeruginosa. A total of four monophages and a cocktail were utilized in the preparation of the PEG-phage ointment. Conclusions: All monophages and their cocktail could completely clear bacterial infection in 17 days. KM3 and KM4 PEG-phage ointments demonstrated more potent healing activity than standard, which required 12 days for full recovery, while the cocktail took 15 days (KM5). However, KM1 and KM2 took the same time as the standard, which is 17 days for burn wound infection treated with PEG-phage ointments, while the control, which did not receive any treatment, took 23 days to recover. KM1 and KM2 show less activity for healing burn wound infections from all five phage ointments.
Predictors of students’ SQ3R in Learning Statistics During Distance Education: an Ordinal Logit Modeling
Authors: Casinillo Leomarich F , Hungo Melbert , Hermano Rujube
Published: June 2024

Studying statistics during distance education is challenging due to limitations and communication problems. This has an impact on learning activities that could be more optimal. This research aims to analyze students' SQ3R level in learning statistics and determine its significant predictors. This type of research is quantitative research. The research design of this study is complex correlational research. The data collection method uses a questionnaire. Data analysis techniques use descriptive and inferential statistics. Secondary data from existing research studies were used and summarized using standard statistical metrics. In addition, ordinal regression analysis was used to determine the predictors of students' SQ3R level in statistics learning and was tested at a standard significance level. Findings reveal that students usually use the SQ3R method to learn statistics during online learning. The statistical model illustrates that students' ability to read and review statistics is shaped by the learning environment, teaching attitudes, physical and emotional health, and free time activities. The study suggests that to improve students' learning of statistics in distance education, educational institutions and professors should create a conducive learning environment, use strategic teaching methods, and emphasize the importance of harmonious study habits due to the SQ3R method.
CRIMINOLOGICAL REVIEW OF THE CRIME OF PROSTITUTION IN A GROUP OF SEXUAL FANTASY PERFORMER ON SOCIAL MEDIA
Authors: Tejo Eko Susanto , Kurniati Yeti , RAS Hernawati
Published: June 2024

The development of information technology has changed people's lives with new habits. Almost everyone has a smartphone and has a social media account. Such rapid evolution has changed human life in various fields and has given birth to new forms of legal action. Among them, there are groups of sexual fantasists who use social media as a means to network and find partners. Sexual fantasies are normal and can have a positive impact if applied correctly. However, currently many people use social media to find partners for sexual fantasies by uploading vulgar photos or videos and requiring them to give money, gifts and provide facilities if they want to carry out sexual fantasies with them. This research uses empirical juridical methods and analytical descriptive research specifications. Based on the research results, it can be concluded that the cause of criminal acts of pornography and prostitution in the form of sexual fantasies using social media is the negative impact of the development of information technology, social media, a manifestation of cultural deviation, deviation from norms, and a manifestation of the absence of norms (anomie). Efforts that can be made to overcome this problem are by carrying out cyber patrols, cutting off access to electronic systems that violate laws and regulations, and carrying out repressive efforts against the perpetrators.
ACTION THAT CAN BE TAKEN BY THE PARTIES AS A RESULT OF DIFFERENCES IN THE RIGHT TO SUSPEND PERFORMANCE REGULATED IN CISG 1980 AND INDONESIA CONTRACT LAW
Authors: Inzaghi Rafly Nauval , Amalia Prita , Trisnamansyah Purnama
Published: June 2024

The United Nations Convention on Contracts for the International Sale of Goods 1980 (CISG 1980) and Indonesian contract law have regulated the right to suspend performance. The arrangement is regulated by Article 71 CISG 1980 and Article 1478 of the Indonesia Civil Code (ICC). Until now, Indonesia has not ratified the CISG 1980. This may result in differences in the regulation of the right to suspend performance between CISG 1980 and the ICC. This difference can cause uncertainty for business actors from Indonesia who conduct international trade in goods with partners from CISG 1980 member countries where CISG 1980 applies to contracts that the parties have made. The uncertainty arises because if there is a conflict between the CISG 1980 and the Indonesian Contract Law, the provisions in the Indonesian Contract Law take precedence as mandatory law. This research will analyze the mechanism of the right to suspend performance regulated in CISG 1980 and Indonesia Contract Law. The research method is a comparative normative judicial research method by comparing the mechanism of suspension of the implementation of obligations contained in the CISG 1980 with the Indonesian Contract Law. This research aims to find what efforts can be made by the parties in the event of a difference between the right to suspend performance regulated in the CISG 19880 and Indonesia Contract Law. The results of this research show that the efforts that can be taken by the partiers are to derogate the applicabilityy ofg CISG 1980 as a whole or only derogate the provision of article 71 CISG 1980.
Pembelajaran Berdiferensiasi Dalam Menulis Teks Berita Di SMPN 7 Kota Jambi
Authors:   Universitas Jambi, Gusneli Ria
Published: June 2024

The aim of this research is to determine the application of differentiated learning in learning news texts at SMPN 7 Jambi City. The approach in this research uses a qualitative approach with a case study type approach. Data collection was carried out by means of interviews, observation and documentation in the field. The results of this research show that the implementation of differentiated learning at the content stage, namely presenting learning material in various ways, namely text-based and audiovisual, at the process stage, namely grouping students based on learning readiness and interest in learning, at the product stage, namely giving freedom to students to create news texts according to their interests (video, writing, sticking on cardboard), and in the learning environment, teachers create a comfortable environment for students. The implementation of differentiated learning runs according to the four aspects of differentiated learning contained in the teaching module. Keywords: Independent curriculum, Differentiated learning, News text