bluuebunny/crossref_metadata_2025 huggingface dataset:
The cost-effectiveness of digital breast tomosynthesis in a population breast cancer screening program
Authors: Wang Jing , Phi Xuan-Anh , Greuter Marcel J. W. , Daszczuk Alicja M. , Feenstra Talitha L. , Pijnappel Ruud M. , Vermeulen Karin M. , Buls Nico , Houssami Nehmat , Lu Wenli , de Bock Geertruida H.
Published: May 2020

Objectives

To evaluate at which sensitivity digital breast tomosynthesis (DBT) would become cost-effective compared to digital mammography (DM) in a population breast cancer screening program, given a constant estimate of specificity.

Methods

In a microsimulation model, the cost-effectiveness of biennial screening for women aged 50–75 was simulated for three scenarios: DBT for women with dense breasts and DM for women with fatty breasts (scenario 1), DBT for the whole population (scenario 2) or maintaining DM screening (reference). For DM, sensitivity was varied depending on breast density from 65 to 87%, and for DBT from 65 to 100%. The specificity was set at 96.5% for both DM and DBT. Direct medical costs were considered, including screening, biopsy and treatment costs. Scenarios were considered to be cost-effective if the incremental cost-effectiveness ratio (ICER) was below €20,000 per life year gain (LYG).

Results

For both scenarios, the ICER was more favourable at increasing DBT sensitivity. Compared with DM screening, 0.8–10.2% more LYGs were found when DBT sensitivity was at least 75% for scenario 1, and 4.7–18.7% when DBT sensitivity was at least 80% for scenario 2. At €96 per DBT, scenario 1 was cost-effective at a DBT sensitivity of at least 90%, and at least 95% for scenario 2. At €80 per DBT, these values decreased to 80% and 90%, respectively.

Conclusion

DBT is more likely to be a cost-effective alternative to mammography in women with dense breasts. Whether DBT could be cost-effective in a general population highly depends on DBT costs.

Key Points

• DBT could be a cost-effective screening modality for women with dense breasts when its sensitivity is at least 90% at a maximum cost per screen of €96.

• DBT has the potential to be cost-effective for screening all women when sensitivity is at least 90% at a maximum cost per screen of €80.

• Whether DBT could be used as an alternative to mammography for screening all women is highly dependent on the cost of DBT per screen.
Evaluation of radiological instability signs in the distal radioulnar joint in children and adolescents with arthroscopically-verified TFCC tears
Authors: Schachinger Florian , Wiener Sascha , Carvalho Marcos F. , Weber Michael , Ganger Rudolf , Farr Sebastian
Published: May 2020

Introduction

Recent reports in the adult literature reported the use of standardized radiographic measurement techniques to determine distal radioulnar joint (DRUJ) instability. The aim of this study was to evaluate the efficacy and accuracy of (1) the MRI-based modified radioulnar ratio technique and (2) the pisoscaphoid (PiSca) and radioulnar (RaUl) distances in true lateral radiographs in children and adolescents with arthroscopically-verified TFCC tears.

Materials and methods

We retrospectively assessed lateral wrist radiographs and axial MRI sequences of 18 adolescent patients (22 wrists) who had arthroscopically-confirmed TFCC tears and compared them to similar imaging of a control group of 28 healthy patients (28 wrists). Three raters assessed the images twice in a 2-week interval. Intraclass correlation coefficients (ICCs), unifactorial ANOVA, and ROC analysis were performed with regards to the different radiographic variables.

Results

The interrater ICCs were almost perfect for all measurements except RaUl1, which showed a substantial agreement (0.751) among the three observers. The intrarater ICCs were almost perfect when measuring PiSca and MRI, and substantial to almost perfect for RaUl. Pearson‘s correlation showed a moderate, positive correlation between PiSca and RaUl distances (r = 0.608; p < 0.001), and a moderate, negative correlation between RaUl distance and MRI shift (r = − 0.486; p = 0.010). When the three core groups (peripheral, central tear, controls) were compared to each other regarding the radiographic instability parameters, only the MRI shift revealed a statistically significant difference (p = 0.003). Comparisons revealed significant differences between patients and controls (p = 0.004) and peripheral tears vs. controls (p = 0.001 and p = 0.010). The ROC analysis revealed a significant AUC only for the MRI (AuC 0.787 and p = 0.002).

Conclusions

Children and adolescents with peripheral TFCC tears showed significantly increased instability parameters in MRI compared to controls. These measurement techniques are no replacement for a thorough clinical examination but may be helpful for indicating diagnostic wrist arthroscopy in ambiguous cases.

Level of evidence

Level III; Diagnostic.
Arthroscopic surgery versus physiotherapy for femoroacetabular impingement: a meta-analysis study
Authors: Gatz Matthias , Driessen Arne , Eschweiler Jörg , Tingart Markus , Migliorini Filippo
Published: May 2020

Introduction

Femoroacetabular impingement (FAI) is thought to play an important role in the development of hip osteoarthritis. However, there is no consensus about the optimal treatment options, since non-operative therapy such as physiotherapy and surgical treatment such as arthroscopic hip surgery can both improve symptoms. Therefore, the aim of the present meta-analysis was to compare the outcomes between two different treatment regimes; physiotherapy versus arthroscopic treatment for FAI.

Methods

The present meta-analysis was carried out according to the PRISMA guidelines. In November 2019, the main online databases were accessed. All the randomized clinical trials (RCTs) comparing surgical arthroscopic treatment versus physiotherapy for FAI were considered for inclusion. Only articles reporting quantitative data under the outcomes of interest were included. For the all analysis, we used Review Manager Software. Data from 644 patients were analysed.

Results

Data from 644 patients were evaluated with a mean follow-up of 14.67 ± 8.3 months. The unpaired t test detected an optimal baseline comparability in terms of side, gender, years, duration of symptoms and BMI (p = 0.08–0.9). The VAS subscale of the score EQ-5D and the mean iHOT33 reported favourable values in the arthroscopic group (p = 0.03 and p < 0.0001, respectively). Similar findings were evidenced in the iHOT33 subgroup 6-months (p = 0.70) and 12-months (p = 0.0002). The HOS score, the ADL (p < 0.0001) and the sport (p = 0.0003) subscales reported both greater values in the arthroscopic group. No statistical significance was found concerning the risk to incur in further total hip arthroplasty (p = 0.72).

Conclusion

Based on only three high-quality RCTs, arthroscopic hip surgery is an effective therapeutic treatment for FAI revealing superior results than a non-surgical approach with physiotherapy.
Hermaphroditism in fishes: an annotated list of species, phylogeny, and mating system
Authors: Kuwamura Tetsuo , Sunobe Tomoki , Sakai Yoichi , Kadota Tatsuru , Sawada Kota
Published: May 2020

Fewer than 1% of vertebrate species are hermaphroditic, and essentially all of these are fishes. Four types of hermaphroditism are known in fishes: simultaneous (or synchronous) hermaphroditism (SH), protandry (male-to-female sex change; PA), protogyny (female-to-male sex change; PG), and bidirectional sex change (BS or reversed sex change in protogynous species). Here we present an annotated list of hermaphroditic fish species from a comprehensive review and careful re-examination of all primary literature. We confirmed functional hermaphroditism in more than 450 species in 41 families of 17 teleost orders. PG is the most abundant type (305 species of 20 families), and the others are much less abundant, BS in 66 species of seven families, SH in 55 species of 13 families, and PA in 54 species of 14 families. The recently proposed phylogenetic tree indicated that SH and PA have evolved several times in not-closely related lineages of Teleostei but that PG (and BS) has evolved only in four lineages of Percomorpha. Examination of the relation between hermaphroditism type and mating system in each species mostly supported the size-advantage model that predicts the evolution of sequential hermaphroditism. Finally, intraspecific variations in sexual pattern are discussed in relation to population density, which may cause variation in mating system.
System-specific systematic errors in earth rotation parameters derived from GPS, GLONASS, and Galileo
Authors: Zajdel Radosław , Sośnica Krzysztof , Bury Grzegorz , Dach Rolf , Prange Lars
Published: May 2020

The earth rotation parameters (ERPs) are time-variable global geodetic parameters with a purely geophysical origin. Theoretically, the estimates of these parameters should be independent of the satellite constellation used in GNSS processing. Nonetheless, clear differences in the time series of ERPs are noticed when using different GNSS constellations. In this study, GPS, GLONASS, and Galileo estimates of ERP have been extensively evaluated in search of system-specific signals. Some of the processing details, such as modeling of the direct solar radiation pressure and length of the orbital arc, also have an impact on the ERP estimates. The GPS-based polar motion estimates are of better quality than those based on GLONASS and Galileo, which are susceptible to deficiencies in the orbit modeling. On the other hand, we observe a systematic bias of GPS-based length-of-day (LoD) with respect to the IERS-C04-14 values with a mean offset of − 22.4 µs/day. The Galileo-based solutions are almost entirely free of this issue. The extension of the orbital arc in the GNSS processing from 1 to 3 days is superior for the quality of the ERPs, especially for pole coordinate rates and LoD. The spurious signals inherently influence the Galileo-based and GLONASS-based ERPs at the frequencies which arise from the resonance between the satellite revolution period and earth rotation, e.g., 3.4 days for Galileo and 3.9 days for GLONASS. These and the draconitic signals overshadow the GNSS-based ERP estimates. Although all the system-specific solutions are affected by the artificial signals, the combination of different GNSS mitigates most of the uncertainties and improves the ERP results.
Modelling Eurasian beaver foraging habitat and dam suitability, for predicting the location and number of dams throughout catchments in Great Britain
Authors: Graham Hugh A. , Puttock Alan , Macfarlane William W. , Wheaton Joseph M. , Gilbert Jordan T. , Campbell-Palmer Róisín , Elliott Mark , Gaywood Martin J. , Anderson Karen , Brazier Richard E.
Published: May 2020

Eurasian beaver (Castor fiber) populations are expanding across Europe. Depending on location, beaver dams bring multiple benefits and/or require management. Using nationally available data, we developed: a Beaver Forage Index (BFI), identifying beaver foraging habitat, and a Beaver Dam Capacity (BDC) model, classifying suitability of river reaches for dam construction, to estimate location and number of dams at catchment scales. Models were executed across three catchments, in Great Britain (GB), containing beaver. An area of 6747 km2 was analysed for BFI and 16,739 km of stream for BDC. Field surveys identified 258 km of channel containing beaver activity and 89 dams, providing data to test predictions. Models were evaluated using a categorical binomial Bayesian framework to calculate probability of foraging and dam construction. BFI and BDC models successfully categorised the use of reaches for foraging and damming, with higher scoring reaches being preferred. Highest scoring categories were ca. 31 and 79 times more likely to be used than the lowest for foraging and damming respectively. Zero-inflated negative binomial regression showed that modelled dam capacity was significantly related (p = 0.01) to observed damming and was used to predict numbers of dams that may occur. Estimated densities of dams, averaged across each catchment, ranged from 0.4 to 1.6 dams/km, though local densities may be up to 30 dams/km. These models provide fundamental information describing the distribution of beaver foraging habitat, where dams may be constructed and how many may occur. This supports the development of policy and management concerning the reintroduction and recolonisation of beaver.
Assessment of process configurations to combine enantioselective chromatography with enzymatic racemization
Authors: Harriehausen Isabel , Wrzosek Katarzyna , Lorenz Heike , Seidel-Morgenstern Andreas
Published: May 2020

Enantioselective chromatography is nowadays a reliable tool for single enantiomer production from a racemate. The recovery of the distomer by racemization and recycling is a promising method to tackle the 50% yield constraint and to increase the productivity. In this paper three process configurations are compared. The production of enantiopure mandelic acid and methionine enantiomers exploiting different enzymes for racemization are evaluated as part of different chromatographic process configurations. First, the benefits of conventional simulated moving bed (SMB) chromatography in contrast to a single column batch separation unit are assessed in integrated configurations. Then, a concept of coupling the racemization with a simpler three-zone SMB unit, where one regeneration zone is removed, is evaluated.
Reading Geography and Geographers and Political Geography today
Authors: Hall Katharine
Published: May 2020

This reflection focuses on reading Geography and Geographers and Political Geography today. In particular, it examines these texts in relation to the contexts of the changing nature and structure of the university and the persistence of white supremacy and anti-black violence in our contemporary moment. In doing so, I look at how these texts might better include some of these challenges—to consider the increasing precarity of the academic job market and to better incorporate black geographies as foundational to the field.
Non-addictive Information Systems
Authors: Kloker Simon
Published: May 2020

Addiction in the context of information technology gained increased public interest within the last years. Only recently, companies like Apple, Google, and Instagram announced to fight smartphone addiction and integrated matching features in their systems. However, if and how these features really help is still an open question. At present, there is only a very rudimentary understanding of IT-triggered disorders and addictions in information systems. Even in clinical research, there is no consensus on the nature of these addictions yet. Nevertheless, the omnipresence of information technology in our daily lives and its unpredictable effects on our moods require this problem to be addressed in a profound manner. This paper links findings from psychology and neuroscience to the information systems terminology and derives the Four-Component Model for Non-addictive Information Systems (4-NAIS). The 4-NAIS allows locating how information technology interacts with the reinforcement cycle of addictions and provides a deeper understanding of where interventions and design decisions may really help tackle IT-triggered disorders.
Understanding dysnatremia
Authors: Voets Philip J. G. M. , Vogtländer Nils P. J. , Kaasjager Karin A. H.
Published: May 2020

Dysnatremia—either hyponatremia or hypernatremia—is frequently encountered in the clinical practice and often poses a diagnostic and therapeutic challenge for physicians. Despite their frequent occurrence, disorders of the water and sodium balance in the human body have puzzled many physicians over the years and often remain elusive for those lacking experience in their interpretation and management. In this article, we derive a transparent governing equation that can be used by clinicians to describe how a change in relevant physiological parameters will affect the plasma sodium concentration. As opposed to many existing models, our model takes both input and output into account, and integrates osmolarity and tonicity. Our governing equation should be considered a means for clinicians to get a better qualitative understanding of the relationship between the plasma sodium concentration and the variables that influence it for a wide range of scenarios.
Identification and characterization of the bZIP transcription factor family in yellowhorn
Authors: Chang Qiaoying , Lu Xin , Liu Zhi , Zheng Zhimin , Yu Song
Published: May 2020

The basic leucine zipper (bZIP) transcription factor family is one of the largest and most diverse families in plants, regulating plant growth and development and playing an essential role in response to abiotic and biotic stresses. However, little is known about the biological functions of bZIP proteins in yellowhorn (Xanthoceras sorbifolium). Recently, 64 XsbZIP genes were identified in the yellowhorn genome and found to be disproportionately distributed in linkage groups. The XsbZIP proteins clustered into 11 groups based on their phylogenetic relationships with AtbZIP, ZmbZIP and GmbZIP proteins. Five intron patterns in the basic and hinge regions and additional conserved motifs were defined, both supporting the group classification and possibly contributing to their functional diversity. Compared to tandem duplication, the segment duplication greatly contributed to the expansion of yellowhorn bZIP genes. In addition, most XsbZIP genes harbor several stress responsive cis-elements in their promoter regions. Moreover, the RNA-seq and qRT-PCR data indicated XsbZIP genes were extensively involved in response to various stresses, including salt (NaCl), cold and abscisic acid, with possibly different molecular mechanisms. These results provide a new understanding of the biological functions of bZIP transcription factors in yellowhorn.
Reliability of dynamic fluoroscopy for medial elbow stability in the presence of radial head resection
Authors: Bergmann Moritz , El-Barbari Jan , Porschke Felix , Grützner Paul A. , Guehring Thorsten , Schnetzke Marc
Published: May 2020

Background

The aim of this study was to examine whether dynamic fluoroscopy is reliable for assessment of medial elbow stability in the presence of radial head resection and different stages of medial collateral ligament (MCL) dissection in a cadaveric elbow model.

Materials and methods

Six intact elbow specimens were measured for joint angulation while applying valgus stress in four examination conditions (Examiner 1, Examiner 2, 1 Nm, 2 Nm) in four different elbow positions (fully pronated or supinated at 0° of elbow extension and 30° of elbow flexion). The elbow specimens were examined for valgus stress in three stages: (1) intact, (2) after radial head resection, and (3) after subsequent dissection of the complete MCL. Anteroposterior radiographs of the elbow were made at each stage to determine joint angulation. Intraclass correlation coefficients (ICCs) were calculated.

Results

In intact elbows, mean joint angulation ranged from 2.2° ± 2.0 (1 Nm) to 5.2° ± 2.3 (Examiner 1). Radial head resection did not increase joint angulation during valgus stress, regardless of joint position and examination condition (Examiner 1: 5.5°; Examiner 2: 5.0°; 1 Nm: 2.6°, 2 Nm: 3.9°). Additional dissection of the MCL led to significantly higher joint angulation during measurements with the standardized torques (1 Nm: 12.4°; 2 Nm: 23.3°). Very good to excellent ICCs for joint angulation between Examiner 1 and Examiner 2 (0.861 to 0.959) were found.

Conclusion

Dynamic fluoroscopy is a reliable diagnostic tool for determining medial elbow stability in the presence of radial head resection and different stages of MCL dissection.
Molecular cloning and characterization of five genes from embryogenic callus in Miscanthus lutarioriparius
Authors: Zhao Lingling , Zeng Xiaofei , Hu Xiaohu , Sheng Jiajing , Zhu Fenglin , Zhong Lin , Zhou Fasong , Jin Surong , Hu Zhongli , Diao Ying
Published: May 2020

The regeneration from embryogenic callus of higher plants in tissue culture is regulated by explants types and developmental stage and also regulated by some genes. In Miscanthus lutarioriparius, five candidate genes were selected to decide the differential expression between embryogenic and non-embryogenic calli, including MlARF-GEP (guanine nucleotide-exchange protein of ADP ribosylation factor), MlKHCP (kinesin heavy chain like protein), MlSERK1 (somatic embryogenesis receptor-like kinases 1), MlSERK2 (somatic embryogenesis reportor-like kinases 2), and MlTypA (tyrosine phosphorylation protein A) with Genbank accession numbers KU640196–KU640200. Multiple sequence alignment analysis showed that five genes were highly conserved among members of their gene families respectively. Phylogenetic relationship analysis showed that five genes were closest with homologous genes of Zea mays and Sorghum. The qRT-PCR results showed significant differences of five genes expression pattern between two different callus types, the relative expression in embryogenic callus was detected to exceed in non-embryogenic callus. Furthermore, simple sequence repeats (SSR) marker statistics results via Chi-square showed a significant correlation between MlSERK1 genotype and induction of embryogenic callus in M. lutarioriparius. This study may lay the foundation of the molecular mechanism on the embryogenic callus induction of M. lutarioriparius and perhaps provide some gist for further study on genetic manipulation.
Correction to: Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study
Authors:   The UBI Study Group, Di Iorio Biagio R. , Bellasi Antonio , Raphael Kalani L. , Santoro Domenico , Aucella Filippo , Garofano Luciano , Ceccarelli Michele , Di Lullo Luca , Capolongo Giovanna , Di Iorio Mattia , Guastaferro Pasquale , Capasso Giovambattista
Published: May 2020

It occurred to us that a simple but significant calculation error was made in Table 2 in the dose of bicarbonate administered. Indeed, contrary to what reported in Table 2, the dose of sodium bicarbonate administered during study was:
Placebo Brain Stimulation Affects Subjective but Not Neurocognitive Measures of Error Processing
Authors: van Elk Michiel , Groenendijk Eva , Hoogeveen Suzanne
Published: May 2020

The aim of this preregistered EEG study was to show how expectations about enhanced or impaired performance through transcranial stimulation affect feelings of agency and error processing. Using a single-blind experimental design, participants (N = 57) were attached to a transcranial direct current stimulation (tDCS) device, and in different blocks, they were verbally instructed to expect enhanced or impaired cognitive performance, or no effects of the brain stimulation. In all cases, but unbeknownst to the participants, we used an inert sham tDCS protocol. Subsequently, we measured their response to errors on a cognitive control task. Our expectancy manipulation was successful: participants reported improved subjective performance in the enhancement compared with the impairment condition—even though objective performance was kept at a constant level across conditions. Participants reported the highest feelings of agency over their task performance in the control condition, and lowest feelings of agency in the impairment condition. The expectancy manipulation did not affect the error-related negativity (ERN) in association with incorrect responses. During the induction phase, expecting impaired versus enhanced performance increased frontal theta power, potentially reflecting a process of increased cognitive control allocation. Our findings show that verbally induced manipulations can affect subjective performance on a cognitive control task, but that stronger manipulations (e.g., through conditioning) are necessary to induce top-down effects on neural error processing.
Connecting Middle Palaeolithic Datasets: the Interplay of Zooarchaeological and Lithic Data for Unravelling Neanderthal Behaviour
Authors: Ruebens Karen , Smith Geoff M. , Dogandžić Tamara , Steele Teresa E.
Published: May 2020

The ongoing refinement of archaeological excavation and recording methods over the last decades has led to a significant increase in quantitative Middle Palaeolithic datasets that provide a record of past Neanderthal behaviour. Stone tools and butchered animal remains are the two main categories of Middle Palaeolithic archaeological remains and both provide distinctive insights into site formation and Neanderthal behaviour. However, the integration of these quantitative lithic and zooarchaeological datasets is key for achieving a full understanding of both site-specific and broader-scale patterns of Middle Palaeolithic subsistence. To explore novel ways to enhance the incorporation of these datasets, we organised a session at the 82nd annual meeting of the Society for American Archaeology in Vancouver. An underlying theme was the problem of linking lithic and faunal variability. Are variations in subsistence strategies reflected by changes in toolmaking decisions? This paper will briefly introduce the possible ways these Middle Palaeolithic datasets can be integrated, illustrated with the papers included in this special volume, and discuss its potential for understanding the variability and interconnectedness of Neanderthal technologies and subsistence strategies.
Shaeer’s Punch Technique: Transcorporeal Peyronie’s Plaque Surgery and Penile Prosthesis Implantation
Authors: Shaeer Osama , Soliman Abdelrahman Islam Fathy , Mansour Mohamed , Shaeer Kamal
Published: May 2020

Background

Penile prosthesis implantation in cases of severe Peyronie’s disease may require plaque excision/incision and grafting, which may require mobilization of the neurovascular bundle or urethra, posing the risks of penile hyposensitivity or urethral injury, and is time-consuming, possibly increasing infection risk.

Aim

Evaluating transcorporeal debulking of Peyronie’s plaques by “Shaeer’s punch technique.”

Methods

Penile prosthesis implantation and punch technique (PPI-Punch) was performed for 26 patients. After corporotomy and dilatation, Peyronie’s plaques were punched out from within the corpora cavernosa using the punch forceps, and then a penile prosthesis was implanted. Comparison to a matching retrospective group of 18 patients operated upon by plaque excision-grafting and penile prosthesis implantation was performed.

Outcomes

The study outcomes were straightness of the erect penis, complication, satisfaction with length on a 5-point scale, the International Index of Erectile Function-5, and the Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire.

Results

Average preoperative curvature angle was 58.1 ± 11.7 in the Punch group and 58 ± 14.8 in the excision-grafting group, p=0.99. After surgery, all patients had a straight penis. No tunical perforations, urethral injuries, or extrusions were noted. Average additional operative time for Punch technique ranged from 5 to 10 minutes (7.3 ± 1.7), in contrast to the excision-grafting group where plaque surgery duration was 50.8 minutes ± 11.1, an 85% difference, p < 0.0001. Septal plaques in the latter group could not be removed. In the PPI-Punch group, penile sensitivity was preserved in all patients, compared with the excision/grafting group, with 7 of 18 patients reporting hyposthesia of the glans. Infection occurred in 1 of 26 patients in the PPI-Punch group, compared with 2 of 18 patients in the excision/grafting group. Satisfaction with length on a 5-point scale was 3.8 ± 0.9 in the punch group, versus 3.1 ± 1.1 in the excision-grafting group, p=0.009.

Clinical Implications

The proposed technique is minimally invasive and prompt, possibly decreasing the known complications of plaque surgery and PPI including sensory loss.

Strengths & Limitations

One limitation is the inability to accurately measure preoperative erect length in patients with erectile dysfunction with poor response to intracavernous injections.

Conclusion

Shaeer’s punch technique is a minimally invasive procedure for transcorporeal excavation of Peyronie’s plaques before penile prosthesis implantation, omitting the need for mobilization of the neurovascular bundle or spongiosum, and hence, there is low or no risk for nerve or urethral injury and brief plaque surgery time.
Designing as playing games of make-believe
Authors: Poznic Michael , Stacey Martin , Hillerbrand Rafaela , Eckert Claudia
Published: May 2020

Designing complex products involves working with uncertainties as the product, the requirements and the environment in which it is used co-evolve, and designers and external stakeholders make decisions that affect the evolving design. Rather than being held back by uncertainty, designers work, cooperate and communicate with each other notwithstanding these uncertainties by making assumptions to carry out their own tasks. To explain this, the paper proposes an adaptation of Kendall Walton’s make-believe theory to conceptualise designing as playing games of make-believe by inferring what is required and imagining what is possible given the current set of assumptions and decisions, while knowing these are subject to change. What one is allowed and encouraged to imagine, conclude or propose is governed by socially agreed rules and constraints. The paper uses jet engine component design as an example to illustrate how different design teams make assumptions at the beginning of design activities and negotiate what can and cannot be done with the design. This often involves iteration – repeating activities under revised sets of assumptions. As assumptions are collectively revised, they become part of a new game of make-believe in the sense that there is social agreement that the decisions constitute part of the constraints that govern what can legitimately be inferred about the design or added to it.
Study on Plate Straightening Process Based on Elastic-Plastic B Spline Finite Strip Method
Authors: Sun Jianliang , Sun Mengqian , Jiao Yunjing , Gao Yanan
Published: May 2020

An elastic-plastic B spline finite strip method is proposed to investigate the continuous plate straightening process in this paper. First, the B spline displacement function that satisfies the boundary conditions of simply supported end and free end of the strip element is established, and then the stress-strain matrix is established. Second, the set method of total stiffness matrix based on B spline finite strip method for plate straightening problem is proposed, and the influence of nodal line number and strip elements number on the sparsity of total stiffness matrix is analyzed. Third, the loads on the strip elements are taken as linear uniform distribution, and the transformation matrix between the equivalent linear load and the actual load of the strip element is established. At last, the plate straightening simulation of 11 rolls straightening machine is made based on the elastic-plastic B spline finite strip method, the calculated results agree with the measured results, which approves that the elastic-plastic B spline finite strip method established can be applied to the plate straightening process.
Reconstructing Mousterian landscapes in the southeastern Pyrenees (Roca dels Bous site, Pre-Pyrenees ranges, Spain)
Authors: Benito-Calvo Alfonso , Arnold Lee J. , Mora Rafael , Martínez-Moreno Jorge , Demuro Martina
Published: May 2020

Landscape evolution studies enable us to understand site formation processes affecting past hunter-gatherer settlements. This work presents a landscape reconstruction of Roca dels Bous site (RB), which is a reference site for the Late Mousterian occupation of the incised valleys of the southeastern Pyrenees. For this purpose, we combined geomorphological studies, stratigraphic descriptions, new single-grain optically stimulated luminescence datasets, statistical methods, and geophysical surveys. RB formed by gravitational processes induced by fluvial undermining of the Segre River during changing late Pleistocene climatic conditions. Geomorphological and chronological data combined with fluvial age-incision models suggest that, during Late Mousterian occupation, RB was located very near the Segre floodplain level and closer to water and raw material natural resources than at present. The accumulation of gravitational deposits associated with the archaeological levels occurred at rates of 0.16–0.44 m ka-1, between 55 and 47 ka, coinciding with Marine Oxygen Isotope Stage 3 (MIS3). More detailed comparison with available climatic curves suggests that the dated RB layers were potentially deposited during cold phases within MIS3. This work provides new landscape-based evidence to examine the paleoenvironmental context of Neanderthal presence in the southeastern Pre-Pyrenees, an important region in the debate regarding Neanderthal demise in Western Europe around 40 ka.
Dietary calcium and vitamin K are associated with osteoporotic fracture risk in middle-aged and elderly Japanese women, but not men: the Murakami Cohort Study
Authors: Platonova Kseniia , Kitamura Kaori , Watanabe Yumi , Takachi Ribeka , Saito Toshiko , Kabasawa Keiko , Takahashi Akemi , Kobayashi Ryosaku , Oshiki Rieko , Solovev Aleksandr , Iki Masayuki , Tsugane Shoichiro , Sasaki Ayako , Yamazaki Osamu , Watanabe Kei , Nakamura Kazutoshi
Published: May 2020

Although dietary Ca, vitamin D and vitamin K are nutritional factors associated with osteoporosis, little is known about their effects on incident osteoporotic fractures in East Asian populations. This study aimed to determine whether intakes of these nutrients predict incident osteoporotic fractures. We adopted a cohort study design with a 5-year follow-up. Subjects were 12 794 community-dwelling individuals (6301 men and 6493 women) aged 40–74 years. Dietary intakes of Ca, vitamin D and vitamin K were assessed with a validated FFQ. Covariates were demographic and lifestyle factors. All incident cases of major osteoporotic limb fractures, including those of the distal forearm, neck of humerus, neck or trochanter of femur and lumbar or thoracic spine were collected. Hazard ratios (HR) for energy-adjusted Ca, vitamin D and vitamin K were calculated with the residual method. Mean age was 58·8 (sd 9·3) years. Lower energy-adjusted intakes of Ca and vitamin K in women were associated with higher adjusted HR of total fractures (Pfor trend = 0·005 and 0·08, respectively). When vertebral fracture was the outcome, Pfor trend values for Ca and vitamin K were 0·03 and 0·006, respectively, and HR of the lowest and highest (reference) intake groups were 2·03 (95 % CI 1·08, 3·82) and 2·26 (95 % CI 1·19, 4·26), respectively. In men, there were null associations between incident fractures and each of the three nutrient intakes. Lower intakes of dietary Ca and vitamin K were independent lifestyle-related risk factors for osteoporotic fracture in women but not men. These associations were robust for vertebral fractures, but not for limb fractures.
Effects of different delivering matrices of β-glucan on lipids in mildly hypercholesterolaemic individuals: a meta-analysis of randomised controlled trials
Authors: Xu Dengfeng , Liu Hechun , Yang Chao , Xia Hui , Pan Da , Yang Xian , Yang Ligang , Wang Shaokang , Sun Guiju
Published: May 2020

β-Glucan has been reported for its health benefits on blood lipids in hypercholesterolaemic individuals for years. However, people have paid little attention to the effects of β-glucan in populations with mild hypercholesterolaemia as well as the various delivering matrices. Our objective was to perform a meta-analysis to analyse the effects of β-glucan with different delivering matrices in mildly hypercholesterolaemic individuals. After conducting a comprehensive search in Web of Science, PubMed, Scopus and Cochrane Library, a total of twenty-one randomised controlled trials involving 1120 participants were identified to measure the pooled effect. The overall results indicated that consuming a dose of ≥3 g/d of β-glucan for at least 3 weeks could significantly reduce total cholesterol (TC) (−0·27 mmol/l, 95 % CI −0·33, −0·21,P< 0·001) and LDL-cholesterol (−0·26 mmol/l, 95% CI −0·32, −0·20,P< 0·001) compared with the control group in mildly hypercholesterolaemic individuals, while no significant difference was observed in TAG (−0·03 mmol/l, 95% CI −0·11, 0·06,P= 0·521) and HDL-cholesterol (0·01 mmol/l, 95% CI −0·03, 0·04,P= 0·777). There was evidence for modest unexplained heterogeneity in the meta-analysis. In conclusion, β-glucan can significantly reduce risk factors like TC and LDL-cholesterol for CVD in mildly hypercholesterolaemic individuals; furthermore, it appears that the effects of food matrices with both ‘solid products’ and ‘liquid products’ where β-glucan was incorporated into were ranked as the best way to exert its beneficial properties, while ‘liquid’ and ‘solid’ products were ranked as the second and third positions, respectively.
Examination of methionine stimulation of gene expression in dairy cow mammary epithelial cells using RNA-sequencing
Authors: Hou Xiaoming , Jiang Minghui , Zhou Jinyu , Song Shuyuan , Zhao Feng , Lin Ye
Published: May 2020

In this research communication, a cell model with elevated β-CASEIN synthesis was established by stimulating bovine mammary epithelial cells with 0.6 mM methionine, and the genome-wide gene expression profiles of methionine-stimulated cells and untreated cells were investigated by RNA sequencing. A total of 458 differentially expressed genes (DEGs; 219 upregulated and 239 downregulated) were identified between the two groups. Gene Ontology (GO) analysis showed that the two highest-ranked GO terms in ‘molecular function’ category were ‘binding’ and ‘catalytic activity’, suggesting that milk protein synthesis in methionine-stimulated cells requires induction of gene expression to increase metabolic activity. Kyoto Encyclopedia of Genes and Genomes analysis revealed that within the ‘environmental information processing’ category, the subcategory that is most highly enriched for DEGs was ‘signal transduction’. cGMP-PKG, Rap1, calcium, cAMP, PI3K-AKT, MAPK, and JAK-STAT are the pathways with the highest number of DEGs, suggesting that these signaling pathways have potential roles in mediating methionine-induced milk protein synthesis in bovine mammary epithelial cells. This study provides valuable insights into the physiological and metabolic adaptations in cells stimulated with methionine. Understanding the regulation of this transition is essential for effective intervention in the lactation process.
Changes in visual memory in mild cognitive impairment: a longitudinal study with CANTAB
Authors: Campos-Magdaleno María , Leiva David , Pereiro Arturo X. , Lojo-Seoane Cristina , Mallo Sabela C. , Facal David , Juncos-Rabadán Onésimo
Published: May 2020

Background

Mild cognitive impairment (MCI), as a stage in the cognitive continuum between normal ageing and dementia, is mainly characterized by memory impairment. The aims of this study were to examine CANTAB measures of temporal changes of visual memory in MCI and to evaluate the usefulness of the baseline scores for predicting changes in cognitive status.

Methods

The study included 201 participants aged over 50 years with subjective cognitive complaints. Visual memory was assessed with four CANTAB tests [paired associates learning (PAL), delayed matching to sample (DMS), pattern recognition memory (PRM) and spatial span (SSP)] administered at baseline and on two further occasions, with a follow-up interval of 18–24 months. Participants were divided into three groups according to the change in their cognitive status: participants with subjective cognitive complaints who remained stable, MCI participants who remained stable (MCI-Stable) and MCI participants whose cognitive deterioration continued (MCI-Worsened). Linear mixed models were used to model longitudinal changes, with evaluation time as a fixed variable, and multinomial regression models were used to predict changes in cognitive status.

Results

Isolated significant effects were obtained for age and group with all CANTAB tests used. Interactions between evaluation time and group were identified in the PAL and DMS tests, indicating different temporal patterns depending on the changes in cognitive status. Regression models also indicated that CANTAB scores were good predictors of changes in cognitive status.

Conclusions

Decline in visual memory measured by PAL and DMS tests can successfully distinguish different types of MCI, and considered together PAL, DMS, PRM and SSP can predict changes in cognitive status.
Fault-tolerant functional reactive programming (extended version)
Authors: PEREZ IVAN , GOODLOE ALWYN E.
Published: May 2020

Highly critical application domains, like medicine and aerospace, require the use of strict design, implementation, and validation techniques. Functional languages have been used in these domains to develop synchronous dataflow programming languages for reactive systems. Causal stream functions and functional reactive programming (FRP) capture the essence of those languages in a way that is both elegant and robust. To guarantee that critical systems can operate under high stress over long periods of time, these applications require clear specifications of possible faults and hazards, and how they are being handled. Modeling failure is straightforward in functional languages, and many functional reactive abstractions incorporate support for failure or termination. However, handling unknown types of faults, and incorporating fault tolerance into FRP, requires a different construction and remains an open problem. This work demonstrates how to extend an existing functional reactive framework with fault tolerance features. At value level, we tag faulty signals with reliability and probability information and use random testing to inject faults and validate system properties encoded in temporal logic. At type level, we tag components with the kinds of faults they may exhibit and use type-level programming to obtain compile-time guarantees of key aspects of fault tolerance. Our approach is powerful enough to be used in systems with realistic complexity, and flexible enough to be used to guide system analysis and design, validate system properties in the presence of faults, perform runtime monitoring, and study the effects of different fault tolerance mechanisms.
“Everybody in this community is at risk of dying”: An ethnographic exploration on the potential of integrating a palliative approach to care among workers in inner-city settings
Authors: Stajduhar Kelli I. , Giesbrecht Melissa , Mollison Ashley , d'Archangelo Margo
Published: May 2020

Objective

At the end of life, the need for care increases. Yet, for structurally vulnerable populations (i.e., people experiencing homelessness and poverty, racism, criminalization of illicit drug use, stigma associated with mental health), access to care remains highly inaccessible. Emerging research suggests that enhancing access to palliative care for these populations requires moving care from traditional settings, such as the hospital, into community settings, like shelters and onto the street. Thus, inner-city workers (ICWs) (e.g., housing support and community outreach) have the potential to play pivotal roles in improving access to care by integrating a “palliative approach to care” in their work.

Method

Drawing upon observational field notes and interview data collected for a larger critical ethnographic study, this secondary thematic analysis examines ICWs’ (n = 31) experiences providing care for dying clients and garners their perspectives regarding the constraints and facilitators that exist in successfully integrating a palliative approach to care in their work.

Results

Findings reveal three themes: (1) Approaches, awareness, and training; (2) Workplace policies and filling in the gaps; and (3) Grief, bereavement, and access to supports. In brief, ICWs who draw upon harm reduction strategies strongly parallel palliative approaches to care, although more knowledge/training on palliative approaches was desired. In their continuous work with structurally vulnerable clients, ICWs have the opportunity to build trusting relationships, and over time, are able to identify those in need and assist in providing palliative support. However, despite death and dying is an everyday reality of ICWs, many described a lack of formal acknowledgement by employers and workplace support as limitations.

Significance of results

Findings contribute promising practices for enhancing equitable access to palliative care for society's most vulnerable populations by prioritizing front-line workers’ perspectives on how best to integrate a palliative approach to care where structurally vulnerable populations live and die.
Pertinence of exotic and local green manures for sustainable maize polyculture in Oaxaca, Mexico
Authors: Beaupré Alexandre , Vega Jaime Ruiz , Castañeda H. Ernesto , Benítez Mariana , Van Cauwelaert Emilio Mora , González González Cecilia
Published: May 2020

Green manures are a promising alternative for achieving the sustainable production of maize in the face of low soil fertility and increasingly long canicule periods, particularly in rainfed systems associated with the reproduction of local agrobiodiversity. However, it is necessary to investigate what are the advantages and disadvantages associated with different species of native and exotic pulse, as well as their overall contribution to the sustainable production of maize landraces. In order to do so, we followed the MESMIS method to assess five species of pulse (three native and two exotic) grown with maize in two plots with different soil conditions. This was done in the seasons of 2017 and 2018 the municipality of Villa de Zaachila, Oaxaca, a site with remarkable biological, agricultural and cultural diversity. A fully randomized complete block design was implemented with 11 treatments and three repetitions in the two plots. The output variables of the experiment were: land equivalence ratio, interspecific aggressiveness, content of soil organic matter, decomposition rate, plant survival rate and plant dry biomass. We also evaluated quantitative or qualitative indicators of cost, adaptability and contribution to food security. For all the possible maize-pulse combinations, except for one, polyculture outperformed maize and pulse monocultures. Exotic pulses (Crotalaria junscens spp. and Dolicho lablab) had a better performance in biomass, reincorporation of organic matter and possible nitrogen fixation, as well as greater resistance to drought in the second cycle. The native pulses (Phaseolus vulgaris and Phaseolus coccineus), however, had a greater acceptance and economic output and are important for the food security in our study site. Our results provide quantitative and qualitative elements to design combined schemes of green manures associated with maize that would help tackle current challenges regarding maize productivity, food security and response to climate change.