bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease
Authors: Suzuki Kazushi , Hirakawa Akihiro , Ihara Ryoko , Iwata Atsushi , Ishii Kenji , Ikeuchi Takeshi , Sun Chung‐Kai , Donohue Michael , Iwatsubo Takeshi ,   Alzheimer's Disease Neuroimaging Initiative, Japanese Alzheimer's Disease Neuroimaging Initiative
Published: March 2020

Introduction

Possession of the apolipoprotein E (APOE) ε4 allele advances amyloid β (Aβ) deposition and symptomatic onset of Alzheimer's disease (AD), whereas its effect on the rate of cognitive decline remained controversial. We examined the effects of APOE ε4 allele on cognition in biomarker‐confirmed late mild cognitive impairment (LMCI) and mild AD subjects in the Japanese Alzheimer's Disease Neuroimaging Initiative (J‐ADNI) and North American ADNI (NA‐ADNI).

Methods

The “early AD” (ie, combined LMCI and mild AD) cohort of 649 subjects from J‐ADNI and NA‐ADNI were selected based on positivity of Aβ confirmed by amyloid positron emission tomography (PET) or cerebrospinal fluid testing. The rates of cognitive decline in the Mini Mental State Examination (MMSE), the Clinical Dementia Rating Sum of Boxes (CDR‐SB), and the Alzheimer's Disease Assessment Scale‐cognitive subscale 13 (ADAS‐Cog) from baseline were examined using mixed‐effects model. The effect of ε4 on time to conversion to dementia was also analyzed in LMCI using the Kaplan‐Meier estimator and log‐rank test.

Results

The rates of cognitive decline were not significantly different between ε4 carriers and ε4 non‐carriers in the total early AD cohort, which were affected neither by region nor by the number of ε4 alleles. In LMCI, ε4 carriers showed almost the same progression rates as ε4 non‐carriers, except for a significantly faster decline in MMSE (P = .0282). Time to conversion to demenita was not significantly different between ε4 carriers and ε4 non‐carriers. In ε4‐positive mild AD, the rates of decline in MMSE (P = .003) and CDR‐SB (P = .0071) were slower than those in ε4 non‐carriers.

DISCUSSION

The APOE ε4 allele had little effect on the rates of cognitive decline in the overall biomarker‐confirmed early AD, regardless of region and number of ε4 alleles, with a slight variability in different clinical stages, the ε4 allele being slightly accelerative in LMCI, while decelerative in mild AD.
Heavy Neutral Leptons from low-scale seesaws at the DUNE Near Detector
Authors: Ballett Peter , Boschi Tommaso , Pascoli Silvia
Published: March 2020

Abstract

Heavy nearly-sterile neutrinos are a common ingredient in extensions of the Standard Model which aim to explain neutrino masses, like for instance in Type I seesaw models, or one of its variants. If the scale of the new Heavy Neutral Leptons (HNLs) is sufficiently low, observable signatures can arise in a range of current and upcoming experiments, from the LHC to neutrino experiments. In this article, we discuss the phenomenology of sterile neutrinos in the MeV to GeV mass range, focusing on their decays. We embed our discussion in a realistic mass model and consider the resulting implications. We focus in particular on the impact on the signal of the strong polarisation effects in the beam for Majorana and (pseudo-)Dirac states, providing formulae to incorporate these in both production and decay. We study how the Near Detector of the upcoming Deep Underground Neutrino Experiment can constrain HNL states by searching for their de- cay products inside the detector. We conduct a Monte Carlo background analysis for the most promising signatures, incorporating the detector’s particle identification capabilities, and estimate the experimental sensitivity of DUNE to these particles. We also present an estimate of the ντ -derived HNL flux at DUNE, currently missing in the literature, which allows us to discuss searches for HNLs at higher masses.
Analysis of volatile metabolites from in vitro biofilms of Pseudomonas aeruginosa with thin-film microextraction by thermal desorption gas chromatography-mass spectrometry
Authors: Koehler Timo , Ackermann Imke , Brecht Dominik , Uteschil Florian , Wingender Jost , Telgheder Ursula , Schmitz Oliver J.
Published: March 2020

Cystic fibrosis (CF) is an autosomal recessive inherited disease which leads to a production of thickened mucus in the airways. These conditions are conducive to poly-microbial infections, like chronic lung infection, in which Pseudomonas aeruginosa (P. aeruginosa) is the major pathogenic bacterium colonizing CF lungs at the end of the lifetime of CF patients. This in vitro study uses a P. aeruginosa biofilm model under partly cystic fibrosis conditions, with a sampling of volatile extracellular metabolites. The gas sampling was done with thin-film microextraction (TFME) and commercial polydimethylsiloxane (PDMS) films, whereas the analysis of loaded films was done by gas chromatography coupled to quadrupole mass spectrometry and thermodesorption (TD-GC-qMS). For this purpose, two commercially available films were characterized by means of thermogravimetry coupled to a qMS with atmospheric pressure photo ionization (TG-APPI-qMS), regarding homogeneity and temperature stability. The selected film was cleaned using a method developed in this study. The TD-GC-qMS method was successfully used for standards of volatile metabolites which were known to be produced by P. aeruginosa. Limits of detection and quantification of the method for middle and less polar compounds in low nanomolar range (0.5 nM and 1.5 nM) were achieved. The developed method was finally applied to investigate the extracellular volatile metabolites produced by biofilms of the strain P. aeruginosa DSM 50071 under aerobic and anaerobic conditions. In sum, eleven metabolites could be found under both conditions. Furthermore, it was shown in this study that different oxygen conditions (aerobic and anaerobic) resulted in emitting different extracellular volatile metabolites. Specific metabolites, like 1-undecene (aerobic) and 2-undecanone (anaerobic), could be identified. The results are promising, in that the biofilm model may be applicable for the identification of P. aeruginosa under clinical conditions. Furthermore, the model could be the basis for studying extracellular volatile metabolites from different mono- or co-cultures of various bacteria, as well as the implementation of pulmonary conditions, like these in CF lungs. This possibility allows the development of a non-invasive “at-bedside” breath analysis method for CF patients in focus of various bacterial infections.
A novel calibration strategy based on internal standard–spiked gelatine for quantitative bio-imaging by LA-ICP-MS: application to renal localization and quantification of uranium
Authors: Grijalba Nagore , Legrand Alexandre , Holler Valerie , Bouvier-Capely Céline
Published: March 2020

Mass spectrometry imaging (MSI) using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been employed for the elemental bio-distribution and quantification of uranium (U) in histological tissue sections of rodent kidneys. Kidneys were immediately immersed into 4% paraformaldehyde (PFA) solution for 24 h, Tissue-Tek O.C.T. Compound embedded and stored at − 80 °C until cutting in a cryostat, and mounted in gel-covered glass slides. In order to assure complete ablation of sample, sample preparation and laser conditions were carefully optimized. In this work, a new analytical methodology is presented for performing quantitative laser ablation analyses based on internal standard (thulium, Tm)–spiked gelatine (10% m/v) for correction of matrix effects, lack of tissue homogeneity, and instrumental drift. In parallel, matrix-matched laboratory standards, dosed at different concentrations of U, were prepared from a pool of rat kidneys. The quantitative images of cryo-sections revealed heterogeneous distribution of uranium within the renal tissue, because the cortical concentration was up to 120-fold higher than the medullary concentration.
Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
Authors: Nicholls Jonathan , Alfuraih Abdulrahman M. , Hensor Elizabeth M. A. , Robinson Philip
Published: March 2020

Objective

To determine inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses.

Materials and methods

In all, 64 patients with musculoskeletal soft tissue masses were scanned by two readers prior to biopsy; each taking five measurements of shear wave velocity (m/s) and stiffness (kPa). A single lesion per patient was scanned in transverse and cranio-caudal planes. Depth measurements (cm) and volume (cm3) were recorded for each lesion, for each reader. Linear mixed modelling was performed to assess limits of agreement (LOA), inter- and intra-reader repeatability, including analyses for measured depth and volume.

Results

Of the 64 lesions scanned, 24 (38%) were malignant. Bland-Altman plots demonstrated negligible bias with wide LOA for all measurements. Transverse velocity was the most reliable measure—intraclass correlation (95% CI) = 0.917 (0.886, 1)—though reader 1 measures could be between 38% lower and 57% higher than reader 2 [ratio-scale bias (95% LOA) = 0.99 (0.64, 1.55)]. Repeatability coefficients indicated most disagreement resulted from poor within-reader reproducibility. LOA between readers calculated from means of five repeated measurements were narrower—transverse velocity ratio-scale bias (95% LOA) = 1.00 (0.74, 1.35). Depth affected both estimated velocity and repeatability; volume also affected repeatability.

Conclusion

This study found poor repeatability of measurements with wide LOA due mostly to intra-reader variability. Transverse velocity was the most reliable measure; variability may be affected by lesion depth. At least five measurements should be reported with LOA to assist future comparability between shear wave elastography systems in evaluating soft tissue masses.
Management of myelofibrosis after ruxolitinib failure
Authors: Harrison Claire N , Schaap Nicolaas , Mesa Ruben A
Published: March 2020

Myelofibrosis is a BCR-ABL1–negative myeloproliferative neoplasm characterized by anemia, progressive splenomegaly, extramedullary hematopoiesis, bone marrow fibrosis, constitutional symptoms, leukemic progression, and shortened survival. Constitutive activation of the Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathway, and other cellular pathways downstream, leads to myeloproliferation, proinflammatory cytokine expression, and bone marrow remodeling. Transplant is the only curative option for myelofibrosis, but high rates of morbidity and mortality limit eligibility. Several prognostic models have been developed to facilitate treatment decisions. Until the recent approval of fedratinib, a JAK2 inhibitor, ruxolitinib was the only available JAK inhibitor for treatment of intermediate- or high-risk myelofibrosis. Ruxolitinib reduces splenomegaly to some degree in almost all treated patients; however, many patients cannot tolerate ruxolitinib due to dose-dependent drug-related cytopenias, and even patients with a good initial response often develop resistance to ruxolitinib after 2–3 years of therapy. Currently, there is no consensus definition of ruxolitinib failure. Until fedratinib approval, strategies to overcome ruxolitinib resistance or intolerance were mainly different approaches to continued ruxolitinib therapy, including dosing modifications and ruxolitinib rechallenge. Fedratinib and two other JAK2 inhibitors in later stages of clinical development, pacritinib and momelotinib, have been shown to induce clinical responses and improve symptoms in patients previously treated with ruxolitinib. Fedratinib induces robust spleen responses, and pacritinib and momelotinib may have preferential activity in patients with severe cytopenias. Reviewed here are strategies to ameliorate ruxolitinib resistance or intolerance, and outcomes of clinical trials in patients with myelofibrosis receiving second-line JAK inhibitors after ruxolitinib treatment.
Transitions to slow or fast diffusions provide a general property for in-phase or anti-phase polarity in a cell
Authors: Seirin-Lee S. , Sukekawa T. , Nakahara T. , Ishii H. , Ei S.-I.
Published: March 2020

Cell polarity is an important cellular process that cells use for various cellular functions such as asymmetric division, cell migration, and directionality determination. In asymmetric cell division, a mother cell creates multiple polarities of various proteins simultaneously within her membrane and cytosol to generate two different daughter cells. The formation of multiple polarities in asymmetric cell division has been found to be controlled via the regulatory system by upstream polarity of the membrane to downstream polarity of the cytosol, which is involved in not only polarity establishment but also polarity positioning. However, the mechanism for polarity positioning remains unclear. In this study, we found a general mechanism and mathematical structure for the multiple streams of polarities to determine their relative position via conceptional models based on the biological example of the asymmetric cell division process of C. elegans embryo. Using conceptional modeling and model reductions, we show that the positional relation of polarities is determined by a contrasting role of regulation by upstream polarity proteins on the transition process of diffusion dynamics of downstream proteins. We analytically prove that our findings hold under the general mathematical conditions, suggesting that the mechanism of relative position between upstream and downstream dynamics could be understood without depending on a specific type of bio-chemical reaction, and it could be the universal mechanism in multiple streams of polarity dynamics of the cell.
Sleeping disorders in children
Authors: Sammer A. , Sammer F.
Published: March 2020

In children with sensorimotor dysfunction (SMD), a history of sleeping disorder can be regularly recorded. Many children describe the following sleeping disorders: they need light or at least an open door. Additionally, a parent is needed. They often use soft toys, which are built around them like a wall in order to have close physical contact. In the dark they are afraid because they feel ghosts, a presence or simply a monster under the bed or in the room. Sensorimotor dysfunction (SMD) is a functional disorder of the movement system caused by reversible segmental dysfunctions, mostly in several sensory regions. The SMD is manifested not only through gross and fine motor weaknesses but also through behavioral problems. The SMD is diagnosed using the motocybernetic test (MCT). The symptom of behavioral sleeping disorder is highlighted, especially since it is a general problem both in healthy children and in children with behavioral problems, such as SMD, attention deficit hyperactivity disorder (ADHD) or autism spectrum disorders (ASD). As a therapeutic alternative, the possibilities of manual medicine are emphasized, especially atlas therapy according to Arlen, since the complaints will disappear completely after just a few treatment sessions.
Optimal prize allocations in group contests
Authors: Trevisan Francesco
Published: March 2020

We characterize the optimal prize allocation, namely the allocation that maximizes a group’s effectiveness, in a model of contests. The model has the following features: (i) it allows for heterogeneity between and within groups; (ii) it classifies contests as “easy” and “hard” depending on whether the marginal costs are concave or convex. Thus, we show that in an “easy” contest the optimal prize allocation assigns the entire prize to one group member, the most skilled one. Conversely, all group members receive a positive share of the prize when the contest is “hard” and players have unbounded above marginal productivities. If the contest is “hard” and the marginal productivities are bounded above, then only the most skilled group members are certain of receiving a positive share of the prize for any distribution of abilities. Finally, we study the effects of a change in the distribution of abilities within a group. Our analysis shows that if the contest is either “easy” or a particular subset of “hard”, then the more the heterogeneity within a group, the higher its probability of winning the prize.
Order patterns, their variation and change points in financial time series and Brownian motion
Authors: Bandt Christoph
Published: March 2020

Order patterns and permutation entropy have become useful tools for studying biomedical, geophysical or climate time series. Here we study day-to-day market data, and Brownian motion which is a good model for their order patterns. A crucial point is that for small lags (1 up to 6 days), pattern frequencies in financial data remain essentially constant. The two most important order parameters of a time series are turning rate and up-down balance. For change points in EEG brain data, turning rate is excellent while for financial data, up-down balance seems the best. The fit of Brownian motion with respect to these parameters is tested, providing a new version of a forgotten test by Bienaymé.
Scalable synthesis of smooth PS@TiO2 core-shell and TiO2 hollow spheres in the (sub) micron size range: understanding synthesis and calcination parameters
Authors: Lechner Anna M. , Feller Tanja , Song Qimeng , Kopera Bernd A. F. , Heindl Lukas , Drechsler Markus , Rosenfeldt Sabine , Retsch Markus
Published: March 2020

Hollow spheres made from titanium dioxide (TiO2) are interesting structures because of their high surface area and low density, combined with semiconducting properties of the TiO2. However, the synthesis is still challenging because of the high reactivity of the titania precursors. Here, we present a simple, reproducible, and scalable way to synthesize TiO2 hollow spheres in the micrometer/sub-micrometer size range comprising three steps: synthesis of polystyrene template particles, growth of TiO2 shells, and calcination to hollow spheres. We investigate the importance of adjusting the seed particle surface functionalization via the appropriate choice of comonomer during the dispersion polymerization. An aging step and a calcination process at low temperatures are mandatory to retain the particle integrity during the seed particle removal. We provide a detailed characterization of each step of this process including electron microscopy, small angle X-ray scattering, and simultaneous thermal analysis.
Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood
Authors: Maulhardt Holly A. , Marin Alyson M. , diZerega Gere S.
Published: March 2020

Administration of chemotherapeutics as direct injections into tumors offers increased anti-tumor activity and reduced systemic toxicity. In this study, the Renca syngeneic murine xenograft model of renal cancer was used to evaluate the effects of intratumoral (IT) submicron particle docetaxel (NanoDoce®) on tumor growth and immunomodulation. Tumor volume (TV) was compared to controls, including intravenous (IV) chemotherapy. Flow cytometry of peripheral bloods and tumors was used to evaluate immune cell populations. Groups of animals were inoculated with a second Renca tumor at a site distant from the primary tumor. IT NanoDoce significantly reduced primary TV and reduced the growth rates of untreated secondary tumors. CD4+, CD8+ and Treg populations were increased in peripheral bloods from animals administered IT NanoDoce. Additional evaluation of the effect of IT NanoDoce on peripheral and local immune cell populations as well as the impact on sites of distant tumor growth are warranted.
Small Semantic Networks in Individuals with Autism Spectrum Disorder Without Intellectual Impairment: A Verbal Fluency Approach
Authors: Ehlen Felicitas , Roepke Stefan , Klostermann Fabian , Baskow Irina , Geise Pia , Belica Cyril , Tiedt Hannes Ole , Behnia Behnoush
Published: March 2020

Individuals with Autism Spectrum Disorder (ASD) experience a variety of symptoms sometimes including atypicalities in language use. The study explored differences in semantic network organisation of adults with ASD without intellectual impairment. We assessed clusters and switches in verbal fluency tasks (‘animals’, ‘human feature’, ‘verbs’, ‘r-words’) via curve fitting in combination with corpus-driven analysis of semantic relatedness and evaluated socio-emotional and motor action related content. Compared to participants without ASD (n = 39), participants with ASD (n = 32) tended to produce smaller clusters, longer switches, and fewer words in semantic conditions (no p values survived Bonferroni-correction), whereas relatedness and content were similar. In ASD, semantic networks underlying cluster formation appeared comparably small without affecting strength of associations or content.
The Vjosa River corridor: a model of natural hydro-morphodynamics and a hotspot of highly threatened ecosystems of European significance
Authors: Schiemer Fritz , Beqiraj Sajmir , Drescher Anton , Graf Wolfram , Egger Gregory , Essl Franz , Frank Thomas , Hauer Christoph , Hohensinner Severin , Miho Aleko , Meulenbroek Paul , Paill Wolfgang , Schwarz Ulrich , Vitecek Simon
Published: March 2020

Context

Large near-natural rivers have become rare in Europe, a fact reflected in the high conservation status of many riverine ecosystems. While the Balkan still harbors several intact river corridors, most of these are under pressure from planned hydropower constructions. Unfortunately, there is little information available on the hydromorphodynamics and biota of Balkan rivers under threat.

Objectives

We present a synthesis of research on the Vjosa in Southern Albania. Here, longitudinal continuity in water flow, undisturbed sediment transport and intact fluvial dynamics are still maintained, but threatened by two large dams planned in its downstream section. We intend to provide a first multidisciplinary inventory of this river system as an example of the knowledge base required for sound water management decisions in the Balkans.

Methods

Based on field work of a multidisciplinary consortium of scientists from Albania and other countries conducted from 2017 onwards, we summarize the most important findings on geomorphology of the riverine landscape, habitat turnover rates, vegetation ecology and selected animal taxa.

Results

We found evidence that significant areas (86%) of the river corridor are covered by habitats listed in Annex 1 of the European Union Habitats Directive. These are associated with a high number of threatened biota.

Conclusions

Our findings underscore the value of the Vjosa as one of the few remaining reference sites for dynamic floodplains in Europe and as a natural laboratory for interdisciplinary research. We emphasize that such multidisciplinary studies are a prerequisite for informed evaluation of potential impacts caused by hydropower plants.
Muscarinic Toxin 7 Signals Via Ca2+/Calmodulin-Dependent Protein Kinase Kinase β to Augment Mitochondrial Function and Prevent Neurodegeneration
Authors: Saleh Ali , Sabbir Mohammad Golam , Aghanoori Mohamad-Reza , Smith Darrell R. , Roy Chowdhury Subir K. , Tessler Lori , Brown Jennifer , Gedarevich Eva , Kassahun Markos Z. , Frizzi Katie , Calcutt Nigel A. , Fernyhough Paul
Published: March 2020

Mitochondrial dysfunction is implicated in a variety of neurodegenerative diseases of the nervous system. Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) is a regulator of mitochondrial function in multiple cell types. In sensory neurons, AMP-activated protein kinase (AMPK) augments PGC-1α activity and this pathway is depressed in diabetes leading to mitochondrial dysfunction and neurodegeneration. Antimuscarinic drugs targeting the muscarinic acetylcholine type 1 receptor (M1R) prevent/reverse neurodegeneration by inducing nerve regeneration in rodent models of diabetes and chemotherapy-induced peripheral neuropathy (CIPN). Ca2+/calmodulin-dependent protein kinase kinase β (CaMKKβ) is an upstream regulator of AMPK activity. We hypothesized that antimuscarinic drugs modulate CaMKKβ to enhance activity of AMPK, and PGC-1α, increase mitochondrial function and thus protect from neurodegeneration. We used the specific M1R antagonist muscarinic toxin 7 (MT7) to manipulate muscarinic signaling in the dorsal root ganglia (DRG) neurons of normal rats or rats with streptozotocin-induced diabetes. DRG neurons treated with MT7 (100 nM) or a selective muscarinic antagonist, pirenzepine (1 μM), for 24 h showed increased neurite outgrowth that was blocked by the CaMKK inhibitor STO-609 (1 μM) or short hairpin RNA to CaMKKβ. MT7 enhanced AMPK phosphorylation which was blocked by STO-609 (1 μM). PGC-1α reporter activity was augmented up to 2-fold (p < 0.05) by MT7 and blocked by STO-609. Mitochondrial maximal respiration and spare respiratory capacity were elevated after 3 h of exposure to MT7 (p < 0.05). Diabetes and CIPN induced a significant (p < 0.05) decrease in corneal nerve density which was corrected by topical delivery of MT7. We reveal a novel M1R-modulated, CaMKKβ-dependent pathway in neurons that represents a therapeutic target to enhance nerve repair in two of the most common forms of peripheral neuropathy.
Patients who do not complete cardiac rehabilitation have an increased risk of cardiovascular events during long-term follow-up
Authors: Sunamura M. , ter Hoeve N. , van den Berg-Emons R. J. G. , Boersma E. , Geleijnse M. L. , van Domburg R. T.
Published: March 2020

Background

Cardiac rehabilitation (CR) has favourable effects on cardiovascular mortality and morbidity. Therefore, it might reasonable to expect that incomplete CR participation will result in suboptimal patient outcomes.

Methods

We studied the 914 post-acute coronary syndrome patients who participated in the OPTImal CArdiac REhabilitation (OPTICARE) trial. They all started a ‘standard’ CR programme, with physical exercises (group sessions) twice a week for 12 weeks. Incomplete CR was defined as participation in <75% of the scheduled exercise sessions. Patients were followed-up for 2.7 years, and the incidence of cardiac events was recorded. Major adverse cardiac events (MACE) included all-cause mortality, non-fatal myocardial infarction and coronary revascularisation.

Results

A total of 142 (16%) patients had incomplete CR. They had a higher incidence of MACE than their counterparts who completed CR (11.3% versus 3.8%, adjusted hazard ratio [aHR] 2.86 and 95% confidence interval [CI] 1.47–5.26). Furthermore, the incidence of any cardiac event, including MACE and coronary revascularisation, was higher (20.4% versus 11.0%, aHR 1.54; 95% CI 0.98–2.44). Patients with incomplete CR were more often persistent smokers than those who completed CR (31.7% versus 11.5%), but clinical characteristics were similar otherwise.

Conclusion

Post-ACS patients who did not complete a ‘standard’ 12-week CR programme had a higher incidence of adverse cardiac events during long-term follow-up than those who completed the programme. Since CR is proven beneficial, further research is needed to understand the reasons why patients terminate prematurely.
The effect of ageing on skeletal muscle as assessed by quantitative MR imaging: an association with frailty and muscle strength
Authors: Farrow M. , Biglands J. , Tanner S. F. , Clegg A. , Brown L. , Hensor E. M. A. , O’Connor P. , Emery P. , Tan A. L.
Published: March 2020

Background

Skeletal muscles undergo changes with ageing which can cause sarcopenia that can result in frailty. Quantitative MRI may detect the muscle-deficit component of frailty which could help improve the understanding of ageing muscles.

Aims

To investigate whether quantitative MRI measures of T2, fat fraction (FF), diffusion tensor imaging and muscle volume can detect differences within the muscles between three age groups, and to assess how these measures compare with frailty index, gait speed and muscle power.

Methods

18 ‘young’ (18–30 years), 18 ‘middle-aged’ (31–68 years) and 18 ‘older’ (> 69 years) healthy participants were recruited. Participants had an MRI of their dominant thigh. Knee extension and flexion power and handgrip strength were measured. Frailty (English Longitudinal Study of Ageing frailty index) and gait speed were measured in the older participants.

Results

Young participants had a lower muscle MRI T2, FF and mean diffusivity than middle-aged and older participants; middle-aged participants had lower values than older participants. Young participants had greater muscle flexion and extension power, muscle volume and stronger hand grip than middle-aged and older participants; middle-aged participants had greater values than the older participants. Quantitative MRI measurements correlated with frailty index, gait speed, grip strength and muscle power.

Discussion

Quantitative MRI and strength measurements can detect muscle differences due to ageing. Older participants had raised T2, FF and mean diffusivity and lower muscle volume, grip strength and muscle power.

Conclusions

Quantitative MRI measurements correlate with frailty and muscle function and could be used for identifying differences across age groups within muscle.
Main geological and mining factors affecting ground cracks induced by underground coal mining in Shanxi Province, China
Authors: Lian Xugang , Hu Haifeng , Li Tao , Hu Dongsheng
Published: March 2020

As one of the largest coal-rich provinces in China, Shanxi has extensive underground coal-mining operations. These operations have caused numerous ground cracks and substantial environmental damage. To study the main geological and mining factors influencing mining-related ground cracks in Shanxi, a detailed investigation was conducted on 13 mining-induced surface cracks in Shanxi. Based on the results, the degrees of damage at the study sites were empirically classified into serious, moderate, and minor, and the influential geological and mining factors (e.g., proportions of loess and sandstone in the mining depth, ratio of rock thickness to mining thickness, and ground slope) were discussed. According to the analysis results, three factors (proportion of loess, ratio of rock thickness to mining thickness, and ground slope) play a decisive role in ground cracks and can be respectively considered as the critical material, mechanical, and geometric conditions for the occurrence of mining surface disasters. Together, these three factors have a strong influence on the occurrence of serious discontinuous ground deformation. The results can be applied to help prevent and control ground damage caused by coal mining. The findings also provide a direct reference for predicting and eliminating hidden ground hazards in mining areas.
Understanding barriers to BIM implementation: Their impact across organizational levels in relation to BIM maturity
Authors: Siebelink Sander , Voordijk Hans , Endedijk Maaike , Adriaanse Arjen
Published: March 2020

This multiple case study of a contracting firm contributes to understanding the barriers that organizations face during the implementation of building information modeling (BIM) by providing insights into the impact of these barriers across different organizational levels (i.e., from top management to project teams) and by relating these barriers to different degrees of BIM maturity. First, we observe the dominance of barriers related to the motivation, competence, and time capacity of people across all levels of an organization. Second, the cluster of barriers at the middle-management level highlights the important role of this level in reducing these barriers. Third, only those cases with a low level of BIM maturity have struggled with lack of top management support, thereby highlighting the importance of such support in achieving BIM maturity growth. High BIM maturity situations are more prone to externally oriented barriers in attempting to further leverage the benefits of BIM. Our study provides insights on where to focus BIM implementation measures and how to enhance organizational BIM maturity.
Female Orgasm and Overall Sexual Function and Habits: A Descriptive Study of a Cohort of U.S. Women
Authors: Shaeer Osama , Skakke Ditte , Giraldi Annamaria , Shaeer Eman , Shaeer Kamal
Published: March 2020

Introduction

Few studies have investigated women's experiences with orgasm and the factors that they cite as important for their orgasmic function and sexual behavior related to foreplay and sexual stimulation.

Aim

To investigate and describe overall sexual function in a cohort of North American women, with a special focus on orgasmic function, satisfaction, triggers, risk factors, and sexual behavior.

Methods

A total of 303 women aged 18–75 years completed a 100-questionnaire survey, which included the Female Sexual Function Index (FSFI) questionnaire and questions on orgasmic function, duration of sexual activity, sexual behaviors and relationship, and the partner’s sexual function. Statistical analysis was performed using SPSS to illuminate factors affecting sexual function.

Outcomes

The main outcome measures are FSFI score, satisfaction with sexual life, ability to reach orgasm, orgasm frequency, preferred sexual stimulation, and sexual habits.

Results

FSFI scores, which were calculated for the 230 women who reported having had a steady male sex partner in the preceding 6 months, showed that 41% of the 230 women were at risk for female sexual dysfunction (a cutoff less than 26.55) and 21% were dissatisfied with their overall sexual life. Almost 90% of the overall cohort reported good emotional contact with their partner, that their partner was willing to have sex, satisfaction with the partner’s penis size (wherever applicable), and good erectile function and ejaculatory control of their partner (wherever applicable). 81% of the overall cohort claimed to be sexually active. Around 70% (70–72) did reach orgasm frequently, but around 10% never did so. Vaginal intercourse was reported by 62% of the overall cohort as the best trigger of orgasm, followed by external stimulation from the partner (48%) or themselves (37%). External stimulation was reported to be the fastest trigger to orgasm.

Clinical Implications

The knowledge on how women reach orgasm and how it is related to the partners' willingness to have sex and other factors can be incorporated in the clinical work.

Strengths & Limitations

The use of a validated questionnaire and the relative large number of participants are strengths of the study. Limitations are the cross-sectional design, the lack of a sexual distress measure, and a possible selection bias.

Conclusion

Most women in the overall cohort were satisfied overall with their sexual life and partner-related factors, even though 41% (of those who cited a steady sex male partner) were at risk for female sexual dysfunction. Most women did reach orgasm through different kinds of stimulation. Correlation was good between preferred and performed sexual activities and positions.
Multimodal Evaluation of Functional Nerve Regeneration in Transgender Individuals After Phalloplasty with a Free Radial Forearm Flap
Authors: Küenzlen Lara , Nasim Sahra , van Neerven Sabien , Kühn Shafreena , Burger Anna E. , Sohn Michael , Rieger Ulrich M. , Bozkurt Ahmet
Published: March 2020

Background

Constructing a sensitive phallus is a key objective in sex affirmation surgery, but still there is a major lack of evidence in outcome analysis of postoperative sensibility of the newly constructed body part.

Aim

To evaluate the innervation and sensibility of a forearm free-flap neophallus with nerve coaptation by a broad-spectrum follow-up.

Methods

The phallic sensibility of 20 transgender individuals who underwent phalloplasty with a free radial forearm flap was evaluated by a standardized multimodal approach, examining 5 main sensory modalities. Measurements were performed in defined areas at the phallus and at the unoperated forearm as a control area. Additionally, all patients were asked to complete a questionnaire about their subjective quality of life and ability to orgasm.

Outcome

This study evaluated the following parameters: perception of pressure (Semmes-Weinstein monofilaments) and vibration (C64 Hz tuning fork), static two-point discrimination, sharp-blunt and hot-cold discrimination at the phallus and the forearm, sum score of calculated life satisfaction, and ability to orgasm.

Results

Most of the patients (n = 14) were able to perceive 2 or more sensory modalities tested at the newly constructed phallus. 2 patients did not develop any sensibility. Interestingly, the median values for vibration perception were similar for the phallus and the unoperated forearm. Pressure sensibility was present at the phallus, but less than at the forearm. Moreover, sharp-blunt sensibility was present in 11 patients. In contrast, clear cold-warm discrimination could not be achieved, although the majority of patients detected the cold stimulus. A two-point discrimination of up to 23 mm could not be detected in either body part. 15 patients experienced orgasms without difficulty after 23 months (n = 20 after 54 months).

Clinical Implications

We observed successful recovery of sensibility at the phalli for the majority of patients, including the preservation of orgasm.

Strengths & Limitations

Our institution is one of the few centers regularly performing phalloplasties in transgender patients, especially preferring the technique of Gottlieb and Levine. This study contributes to the few studies that perform sensory testing at the phallus and is unique in its kind in that it uses a multimodal approach. A limitation of this study is the limited number of cases and the limited validity of vibratory testing.

Conclusion

Confirming a promising tactile sensibility after phalloplasty with a neurovascular radial forearm flap, the next step would be to identify whether this reinnervation effectively develops due to nerve coaptation or spontaneous sprouting.
Sexual Motivation and Satisfaction Among Consensually Non-Monogamous and Monogamous Individuals
Authors: Mitchell Virginia E. , Mogilski Justin K. , Donaldson Sarah H. , Nicolas Sylis Claire A. , Welling Lisa L.M.
Published: March 2020

Background

Previous research has found differences in sexual motives and, separately, sexual satisfaction in consensually non-monogamous (CNM) and monogamous individuals and that these constructs are related to relationship outcomes (eg, relationship quality).

Aims

The present study sought to refine and expand on previous research by (i) using a more common, validated measure of sexual motives, (ii) measuring sexual satisfaction with multiple partners within CNM relationships, and (iii) examining how sexual motives are related to sexual satisfaction in CNM relationships.

Methods

Participants were recruited from a university and using online forums that CNM individuals frequently use (eg, reddit, Facebook). Individuals recruited included those in non-exclusive relationships with one partner (“non-exclusive single-partner;” n = 40), those in non-exclusive relationships with more than one partner (“non-exclusive multipartner;” n = 87), and monogamous individuals (n = 322). Data were analyzed using multivariate analysis of variance and hierarchical multiple regressions.

Outcomes

The main outcome measures of this study are scores on the Why Humans Have Sex Scale and the New Scale for Sexual Satisfaction.

Results

Non-exclusive multipartner participants were more motivated to have sex for physical motivations compared with monogamous participants. Although there were no significant differences in sexual satisfaction when comparing monogamous with non-exclusive multipartner participant's secondary and primary partners, unique patterns of sexual motivations were associated with sexual satisfaction based on relationship configuration.

Clinical Translation

Understanding the unique sexual motives associated with sexual satisfaction in various relationship configurations may help improve clinical approaches to couples counseling for both CNM and non-CNM populations.

Strengths and Limitations

Data were collected from CNM participants in a variety of relationship configurations and provide analyses comparing primary and secondary partners. However, these results are limited by a small sample of CNM participants who were intentionally recruited from self-identified CNM e-forums.

Conclusions

These findings add further understanding to the unique traits that characterize CNM individuals and the underlying motivational framework that may encourage individuals to initiate and maintain CNM relationships.
Deconstructing Characterizations of Rape, Marriage, and Custom in South Africa: Revisiting The Multi-Sectoral Campaign Against Ukuthwala
Authors: Karimakwenda Nyasha
Published: March 2020

A critique of multi-sectoral responses to the customary practice ofukuthwala(the isiXhosa term for abduction for purposes of marriage) in South Africa highlights attention to gendered tropes pertaining to marriage, custom, and sexual assault. Karimakwenda deconstructs how, in its inflexible framing of customary practice, the multi-sectoral campaign against violent forms of ukuthwala lacks historicization and silences women’s narratives. By obscuring historical and locally-embedded linkages between marriage practices and rape, the myopic campaign energizes collective anxieties around representations of violence within Black communities, and fuels misconceptions surrounding marital rape. This critique contributes to debates about gender, violence, and state power by offering a counter-narrative to simplified characterizations of sexual violence and custom.
Unravelling the New Plebiscitary Democracy: Towards a Research Agenda
Authors: Hendriks Frank
Published: March 2020

Pushed by technological, cultural and related political drivers, a ‘new plebiscitary democracy’ is emerging which challenges established electoral democracy as well as variants of deliberative democracy. The new plebiscitary democracy reinvents and radicalizes longer-existing methods (initiative, referendum, recall, primary, petition, poll) with new tools and applications (mostly digital). It comes with a comparatively thin conceptualization of democracy, invoking the bare notion of a demos whose aggregated will is to steer actors and issues in public governance in a straight majoritarian way. In addition to unravelling the reinvented logic of plebiscitary democracy in conceptual terms, this article fleshes out an empirically informed matrix of emerging formats, distinguishing between votations that are ‘political-leader’ and ‘public-issue’ oriented on the one hand, and ‘inside-out’ and ‘outside-in’ initiated on the other hand. Relatedly, it proposes an agenda for systematic research into the various guises, drivers and implications of the new plebiscitary democracy. Finally, it reflects on possible objections to the argumentation.
Moving Labor Heroes Center Stage: (Labor) Heroism and the Reconfiguration of Social Relations in the Yan'an Period
Authors: Spakowski Nicola
Published: March 2020

Labor heroes are an important phenomenon in the history of socialist China, but they have received only little attention in Western scholarship. This article investigates the labor heroes of the Yan'an period as the pivot in the Chinese Communist Party's (CCP) attempt at reconceptualizing society, establishing new social relations and creating a socialist subjectivity. It reveals the new symbolic order constructed in the official media, primarilyJiefang Ribao(Liberation Daily), and highlights the relation between labor heroes (as representatives of the “masses”), intellectuals, and Mao Zedong in the construction of new hierarchies. In particular, it shows how the CCP chose work as the fundament of socialist society and the core of a new concept of “collective heroism”; how the stage of the first labor hero assembly was used to orchestrate Mao Zedong as a charismatic leader; and how labor heroes and writers, through direct encounter, redefined their respective place in society.
An image-based narrative intervention to manage interview anxiety and performance
Authors: Lin-Stephens Serene
Published: March 2020

A visual narrative intervention – Serious Storytelling with Images – was proposed to manage interview anxiety and performance. Its ability to evocate significant incidents and enhance narratives construction was evaluated ideographically in two case studies. The findings suggest varying levels of sophistication in interviewee actions, challenges encountered, and perceived roles of images. Counselors can refer to the hierarchical concepts when tailoring interview training and coaching. Further investigation is highly recommended to confirm and measure intervention effects.
When Racial Inequalities Return: Assessing the Restratification of Cuban Society 60 Years After Revolution
Authors: Hansing Katrin , Hoffmann Bert
Published: March 2020

Few political transformations have attacked social inequalities more thoroughly than the 1959 Cuban Revolution. As the survey data in this article show, however, sixty years on, structural inequalities are returning that echo the prerevolutionary socioethnic hierarchies. While official Cuban statistics are mute about social differences along racial lines, the authors were able to conduct a unique, nationwide survey with more than one thousand respondents that shows the contrary. Amid depressed wages in the state-run economy, access to hard currency has become key. However, racialized migration patterns of the past make for highly unequal access to family remittances, and the gradual opening of private business disfavors Afro- Cubans, due to their lack of access to prerevolutionary property and startup capital. Despite the political continuity of Communist Party rule, a restructuring of Cuban society with a profound racial bias is turning back one of the proudest achievements of the revolution.
Insurgency, Political Violence, and Democracy in Latin America
Authors: Somma Nicolás M.
Published: March 2020

Once upon a time, pluralist (Dahl 1961) and modernization theories (Lipset 1959) described liberal democracy as a political regime that tended to exclude violence, insurgency, and corruption. A few decades later, Francis Fukuyama (1992) argued that in the long run, liberal democracy would triumph over other political alternatives, and about the same time Samuel Huntington (1991) revealed a massive wave of democratization (or redemocratization) in different parts of the world.
White Evangelicals as a “People”: The Church Growth Movement from India to the United States
Authors: Curtis Jesse
Published: March 2020

This article begins with a simple question: How did white evangelicals respond to the civil rights movement? Traditional answers are overwhelmingly political. As the story goes, white evangelicals became Republicans. In contrast, this article finds racial meaning in the places white evangelicals, themselves, insisted were most important: their churches. The task of evangelization did not stop for a racial revolution. What white evangelicals did with race as they tried to grow their churches is the subject of this article. Using the archives of the leading evangelical church growth theorists, this article traces the emergence and transformation of the Church Growth Movement (CGM). It shows how evangelistic strategies created in caste-conscious India in the 1930s came to be deployed in American metropolitan areas decades later. After first resisting efforts to bring these missionary approaches to the United States, CGM founder Donald McGavran embraced their use in the wake of the civil rights movement. During the 1970s, the CGM defined white Americans as “a people” akin to castes or tribes in the Global South. Drawing on the revival of white ethnic identities in American culture, church growth leaders imagined whiteness as pluralism rather than hierarchy. Embracing a culture of consumption, they sought to sell an appealing brand of evangelicalism to the white American middle class. The CGM story illuminates the transnational movement of people and ideas in evangelicalism, the often-creative tension between evangelical practices and American culture, and the ways in which racism inflected white evangelicals’ most basic theological commitments.