bluuebunny/crossref_metadata_2025 huggingface dataset:
Urinary growth differentiation factor 15 predicts renal function decline in diabetic kidney disease
Authors: Oshita Toma , Watanabe Shun , Toyohara Takafumi , Kujirai Ryota , Kikuchi Koichi , Suzuki Takehiro , Suzuki Chitose , Matsumoto Yotaro , Wada Jun , Tomioka Yoshihisa , Tanaka Tetsuhiro , Abe Takaaki
Published: August 2023

Sensitive biomarkers can enhance the diagnosis, prognosis, and surveillance of chronic kidney disease (CKD), such as diabetic kidney disease (DKD). Plasma growth differentiation factor 15 (GDF15) levels are a novel biomarker for mitochondria-associated diseases; however, it may not be a useful indicator for CKD as its levels increase with declining renal function. This study explores urinary GDF15’s potential as a marker for CKD. The plasma and urinary GDF15 as well as 15 uremic toxins were measured in 103 patients with CKD. The relationship between the urinary GDF15-creatinine ratio and the uremic toxins and other clinical characteristics was investigated. Urinary GDF15-creatinine ratios were less related to renal function and uremic toxin levels compared to plasma GDF15. Additionally, the ratios were significantly higher in patients with CKD patients with diabetes (p = 0.0012) and reduced with statin treatment. In a different retrospective DKD cohort study (U-CARE, n = 342), multiple and logistic regression analyses revealed that the baseline urinary GDF15-creatinine ratios predicted a decline in estimated glomerular filtration rate (eGFR) over 2 years. Compared to the plasma GDF15 level, the urinary GDF15-creatinine ratio is less dependent on renal function and sensitively fluctuates with diabetes and statin treatment. It may serve as a good prognostic marker for renal function decline in patients with DKD similar to the urine albumin-creatinine ratio.
Unique patterns of medial meniscus extrusion during walking and its association with limb kinematics in patients with knee osteoarthritis
Authors: Ishii Yosuke , Ishikawa Masakazu , Nakashima Yuko , Hashizume Takato , Okamoto Saeko , Kamei Goki , Okada Kaoru , Takagi Kazuya , Takahashi Makoto , Adachi Nobuo
Published: August 2023

Medial meniscus extrusion (MME) is exacerbated by repeated mechanical stress. Various factors would affect MME; however, there is limited information about the behaviour of the medial meniscus during walking in patients with knee osteoarthritis (KOA). This study aimed to investigate the pattern of MME during walking and its association with limb biomechanics in patients with KOA. Fifty-five patients with KOA and ten older adult volunteers as a control group were involved in this study. The MME and limb biomechanics during walking were evaluated simultaneously by ultrasound and a motion analysis system, respectively. The waveform was constructed from the values of MME, and the point showing the highest value of MME was identified during the gait cycle. According to the peak timing of MME in the waveform, the pattern of the waveform was evaluated and compared to the control group. Lateral thrust, knee adduction moment (KAM), and flexion moment were obtained from motion analysis, and their association with the MME was evaluated. The patients with KOA demonstrated unique peak timing during walking. Compared to the control group, there were three groups of MME waveforms, early (< 59%), normal (60–83%), and late (> 84%) from the peak timing in the gait cycle. The pattern of MME waveform in early, normal, and late groups was correlated with the first KAM and lateral thrust, second KAM, and knee flexion moment, respectively. A unique MME pattern during walking was demonstrated, and these patterns were associated with limb biomechanics in patients with KOA.
A new fasciocutaneous flap model identifies a critical role for endothelial Notch signaling in wound healing and flap survival
Authors: Dastagir Khaled , Gamrekelashvili Jaba , Dastagir Nadjib , Limbourg Anne , Kijas Dustin , Kapanadze Tamar , Vogt Peter M. , Limbourg Florian P.
Published: August 2023

Flap surgery is a common treatment for severe wounds and a major determinant of surgical outcome. Flap survival and healing depends on adaptation of the local flap vasculature. Using a novel and defined model of fasciocutaneous flap surgery, we demonstrate that the Notch ligand Delta-like 1 (Dll1), expressed in vascular endothelial cells, regulates flap arteriogenesis, inflammation and flap survival. Utilizing the stereotyped anatomy of dorsal skin arteries, ligation of the major vascular pedicle induced strong collateral vessel development by end-to-end anastomosis in wildtype mice, which supported flap perfusion recovery over time. In mice with heterozygous deletion of Dll1, collateral vessel formation was strongly impaired, resulting in aberrant vascularization and subsequent necrosis of the tissue. Furthermore, Dll1 deficient mice showed severe inflammation in the flap dominated by monocytes and macrophages. This process is controlled by endothelial Dll1 in vivo, since the results were recapitulated in mice with endothelial-specific deletion of Dll1. Thus, our model provides a platform to study vascular adaptation to flap surgery and molecular and cellular regulators influencing flap healing and survival.
LC–MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples
Authors: Pedraz-Petrozzi Bruno , Marszalek-Grabska Marta , Kozub Anna , Szalaj Klaudia , Trzpil Alicja , Stachniuk Anna , Lamadé Eva Kathrin , Gilles Maria , Deuschle Michael , Turski Waldemar A. , Fornal Emilia
Published: August 2023

Tryptophan breakdown metabolites formed along the kynurenine pathway play a significant role in pregnancy and fetal development. To understand their involvement, it is crucial to quantify the levels of tryptophan (TRP), kynurenine (KYN), and kynurenic acid (KYNA) in relevant biological samples such as the placenta, fetal membranes, and umbilical cord. This study used liquid chromatography-tandem mass spectrometry (LC–MS/MS) to determine TRP, KYN, and KYNA levels. The LC–MS/MS method was optimized for high sensitivity and specificity, demonstrating good reproducibility with a precision of < 10% CV and an accuracy of 85–115%. The lower limit of quantification for both TRP and KYN was 0.5 µg/ml, while for KYNA, it was 0.5 ng/mL. The method exhibited linearity within the examined range of concentrations in the homogenate, ranging from 0.5 to 30 µg/ml for TRP and KYN and from 0.5 to 25 ng/ml for KYNA. Using this method, we found significant differences in the concentrations of these substances in investigated maternal–fetal compartments. Placenta samples exhibited higher KYN and lower KYNA concentrations than the umbilical cord and fetal membrane, indicating a potentially important role for kynurenines in late pregnancy. Collectively, this finding may facilitate further research and provide inside into the involvement of the kynurenine pathway of TRP metabolism in fetal development.
Similar simulation of overburden movement characteristics under paste filling mining conditions
Authors: Wu Pengfei , Zhao Jihe , Jin Jiaxu
Published: August 2023

The method of filling mining can solve the problem of surface subsidence caused by coal mining. Among them, it is crucial to study the mechanism of filler strength improvement timeliness and filler mining to control rock movement for filler mining. In this paper, by combining theoretical analysis and similar simulation experiments, compressive strength is used as the research parameter to conduct proportioning test research on paste filling similar materials such as coal gangue, fly ash, and cement. The results prove that the strengths of the test ratios can meet the strength design criteria and lay the foundation for the requirements of similar simulation experiments. In order to study the characteristics of overburden failure, stress and displacement in the process of filling mining, the key technical parameters of overburden movement are determined. Similar simulation experiments were conducted to study the movement and deformation of overburden rock and the displacement and stress distribution law of overburden rock in the coal mine under different filling rates and filling steps conditions. The results show that the filling rate and filling step are the keys to preventing the overlying rock from rupture and collapse, and the larger the filling rate is, the smaller the stress and displacement of the overburden; the larger the filling step is, the larger the displacement and stress change of the overburden, and vice versa. In addition, the displacement curve along the strike is basically an "arch" type distribution, and the stress variation trend is "large-small-large" with a "Z" type distribution. The research results are of great significance to guide the practice of filling mining and can provide the theoretical basis for its further promotion.
Gut microbiome and nutrition-related predictors of response to immunotherapy in cancer: making sense of the puzzle
Authors: Hes Cecilia , Jagoe R. Thomas
Published: August 2023

The gut microbiome is emerging as an important predictor of response to immune checkpoint inhibitor (ICI) therapy for patients with cancer. However, several nutrition-related patient characteristics, which are themselves associated with changes in gut microbiome, are also prognostic markers for ICI treatment response and survival. Thus, increased abundance of Akkermansia muciniphila, Phascolarctobacterium, Bifidobacterium and Rothia in stool are consistently associated with better response to ICI treatment. A. muciniphila is also more abundant in stool in patients with higher muscle mass, and muscle mass is a strong positive prognostic marker in cancer, including after ICI treatment. This review explores the complex inter-relations between the gut microbiome, diet and patient nutritional status and the correlations with response to ICI treatment. Different multivariate approaches, including archetypal analysis, are discussed to help identify the combinations of features which may select patients most likely to respond to ICI treatment.
Use of Metal–Organic Frameworks in the Detection Stage of Analysis/Miniaturization Devices
Authors: Sarvestani Mohammad Reza Jalali , Jalal Nahid Rezvani , Khalili Sina , Moeinipour Alieh , Asadi Sepideh , Bastan Narges , Aghajani Samira , Afkhami Abbas , Madrakian Tayyebeh , Ahmadi Mazaher
Published: August 2023

Metal–organic frameworks (MOFs) have prominent features in comparison to conventional porous materials that make them ideal and superior sensing materials for the detection of various organic and inorganic analytes using different types of sensors. Generally, in MOF-based detection systems, any alteration in MOF features that is contingent on the guest molecule (the analyte) can be used as a signal that has a clear relationship with the concentration of the desired analyte. In this respect, MOF-based sensors can be divided into different groups based on the measured sensing signal type including electrochemical, optical, mechanical, and photo-electrochemical sensors. This chapter is focused on the applications of MOFs as sensing materials in different sensor types. The advantages and disadvantages of each type are compared critically and some important conclusions are made for future work.
Development of an MIP based electrochemical sensor for TGF-β1 detection and its application in liquid biopsy
Authors: Siciliano Giulia , Chiriacò Maria Serena , Ferrara Francesco , Turco Antonio , Velardi Luciano , Signore Maria Assunta , Esposito Marco , Gigli Giuseppe , Primiceri Elisabetta
Published: August 2023

Development and characterization of TGF-β1 MIP electrochemical sensor as a tool for POC diagnostics.
Determination of licit and illicit drugs and metabolites in human sweat by liquid chromatography-tandem mass spectrometry
Authors: Sotom Margaret , Bowdler Paul , Honeychurch Kevin C.
Published: August 2023

Simple and effective method for the determination of drugs in human sweat patches following SPE and LC/MS/MS determination.
A CO-mediated photothermal therapy to kill drug-resistant bacteria and minimize thermal injury for infected diabetic wound healing
Authors: Jin Xin , Ou Zelin , Zhang Guowei , Shi Rong , Yang Jumin , Liu Wenguang , Luo Gaoxing , Deng Jun , Wang Wei
Published: August 2023

A CO-mediated photothermal therapy selectively enhances drug-resistant bacteria killing and minimizes tissue thermal injury to promote infected diabetic wound healing.
Radiation-induced photodynamic therapy using calcium tungstate nanoparticles and 5-aminolevulinic acid prodrug
Authors: Viswanath Dhushyanth , Shin Sung-Ho , Yoo Jin , Torregrosa-Allen Sandra E. , Harper Haley A. , Cervantes Heidi E. , Elzey Bennett D. , Won You-Yeon
Published: August 2023

Poly(ethylene glycol-b-lactic acid)(PEG–PLA)-encapsulated CaWO4 nanoparticles represent a novel tool that can enhance the applicability of 5-aminolevulinic acid(ALA)-based photodynamic therapy (PDT) from surface-level tumors to deep-seated tumors.
Towards a simple in vitro surface chemistry pre-screening method for nanoparticles to be used for drug delivery to solid tumours
Authors: Schmid Roman , Kaiser Juliane , Willbold Ramona , Walther Nomusa , Wittig Rainer , Lindén Mika
Published: August 2023

Both nanoparticle uptake efficiency and the selectivity for cancer cells over macrophages need to be taken into account in order to successfully link in vitro data with in vivo outcomes.
Photoredox catalysis in alkene and alkyne alkylsulfonylations: the construction of Markovnikov selective α-sulfones
Authors: Lu Lingyi , Wang Haoran , Huang Shanshan , Xiong Biao , Zeng Xiaobao , Ling Yong , Qiu Xiaodong
Published: August 2023

Herein, we report a photocatalyzed highly regioselective alkylsulfonylation of terminal aryl alkenes or alkynes to access unexpected α-sulfones.
ZnSe@NPSC core–shell nanorods for super sodium ion storage induced from an organic polymer derived N, P, S tri-doped carbon framework
Authors: Wang Haibin , Chen Lantao , Xu Feng , Zhang Yufei , Fan Haosen
Published: August 2023

Core–shell structured ZnSe@NPSC nanorods were prepared with N, P, S hetero-doped carbon shell, which can maintain the capacities of 376.67 mA h g−1 after 150 cycles at 0.5 A g−1 and 359.1 mA h g−1 after 350 cycles at 1.0 A g−1, respectively.
Effect of molten-salt modulation on the composition and structure of g-C3N4-based photocatalysts
Authors: He Fang , Hu Yan , Zhong Hong , Wang Zhenxing , Peng Shaoqin , Li Yuexiang
Published: August 2023

This review focuses on the molten-salt modulation of the composition and structure of g-C3N4-based photocatalysts, which will provide new insights for the facile molten-salt modulation of photocatalysts.
Mechanism to model: a physical organic chemistry approach to reaction prediction
Authors: Reid Jolene P. , Betinol Isaiah O. , Kuang Yutao
Published: August 2023

Combining a working knowledge of reaction mechanism with statistical modelling is a powerful approach to prediction.
Copper nanoparticle-embellished Zr-based metal–organic framework for electrocatalytic hydrogen evolution reaction
Authors: Aparna Ravari Kandy , Karmakar Arun , Arsha Rathnam Tharayil , Kundu Subrata , Mandal Sukhendu
Published: August 2023

Stabilization of small copper nanoparticles in amine functionalized zirconium-based metal–organic framework for efficient electrocatalytic hydrogen evolution reaction.
An investigation into the hybrid architecture of Mn–Co nanoferrites incorporated into a polyaniline matrix for photoresponse studies
Authors: Singh Anshika , Chauhan Pratima , Verma Arpit , Yadav B. C.
Published: August 2023

In this study, an enhanced photoresponse was observed in the Mn–Co Nanoferrites (MCFs)–Polyaniline (PANI) nanohybrid architecture. The excellent performance of the photodetector device could be explained by the intimate interaction between MCFs and PANI at their interface.
Quantum dot (Aun/Agn, n = 3–8) capped single lipids: interactions and physicochemical properties
Authors: Maneri Asma H. , Varode Shruti Suhas , Maibam Ashakiran , Ranjan Priyatosh , Krishnamurty Sailaja , Joshi Krati
Published: August 2023

Assessing binding response of gold and silver quantum dots with lipid molecules.
Structural and thermodynamic properties of bulk triglycerides and triglyceride/water mixtures reproduced using a polarizable coarse-grained model
Authors: Ma Ming , Song Junjie , Dong Yi , Fang Weihai , Gao Lianghui
Published: August 2023

Triglycerides (TGs) play important roles in renewable energies, food production, medicine, and metabolism in organisms.
Manipulating the metal-to-insulator transitions of VO2 by combining compositing and doping strategies
Authors: Zhou Xuanchi , Li Haifan , Shang Yanlong , Meng Fanqi , Li Ziang , Meng Kangkang , Wu Yong , Xu Xiaoguang , Jiang Yong , Chen Nuofu , Chen Jikun
Published: August 2023

The simultaneous regulations of the mechanical strength and the metal-to-insulator transition are achieved in the VO2 bulk, respectively, via compositing VO2 with high-melting-point oxides and substituting vanadium with high-valent dopants.
Facile synthesis of Bi2Se3/nitrogen-doped carbon dot nanoplates for aqueous zinc ion battery cathodes
Authors: Han Yuxin , Jiu Hongfang , Zhang Lixin , Wang Cundong , Yue Luchao , Wang Congli , Guo Zhixin , Che Sicong , Ma Jinfeng , Li Hui
Published: August 2023

Bi2Se3 is a promising cathode material for aqueous zinc ion batteries (AZIBs), but its limited capacity and poor cycling stability deter its further use in the development of AZIBs.
In situ construction of a Sillén–Aurivillius layered perovskite-based 0D/2D homologous Schottky junction for efficient piezo-photocatalytic activity
Authors: Yang Jian , Xue Yali , Han Chuang , Zhang Xiaorui , Sa Ke , Jia Jin , Ye Hanlin , Liang Yujun
Published: August 2023

Under the dual stimulation of ultrasonic and illumination, the synergism of piezoelectric polarization and Schottky junction destroys the interface shielding effect and expedites the charge separation for efficient piezo-photocatalysis.
Porous amorphous metal–organic frameworks based on heterotopic triangular ligands for iodine and high-capacity dye adsorption
Authors: Feng Ying , Wu Liang-Hua , Zhang Chu-Hong , Zhou Bing-Xun , Zheng Sheng-Run , Zhang Wei-Guang , Cai Song-Liang , Fan Jun
Published: August 2023

Two amorphous metal–organic frameworks based on Co(ii) and heterotopic triangular ligands were constructed. Their structures and iodine and dye adsorption properties were studied. They showed higher dye adsorption capacities than many MOFs even though they lack crystallinity.
A giant Nernst power factor and figure-of-merit in polycrystalline NbSb2 for Ettingshausen refrigeration
Authors: Li Peng , Qiu Pengfei , Xiao Jie , Deng Tingting , Chen Lidong , Shi Xun
Published: August 2023

The giant Nernst power factor in polycrystalline NbSb2 is a record-high value in polycrystalline thermomagnetic materials.
An exopolysaccharide from Lactobacillus pentosus YY-112: structure and effect on the human intestinal microbiota
Authors: Yang Ying , Wang Mingzhe , Zhang Hui , Zhou Wanyi , Liu Wei , Pi Xionge , Xing Jianrong
Published: August 2023

The development of novel prebiotics, which could regulate the intestinal microbiota, may help prevent and treat intestinal diseases.
Continuous-flow reductive N-methylation with highly active heterogeneous Pd catalysts and sequential-flow synthesis of N-monomethyl amines
Authors: Saito Yuki , Senzaki Taisei , Nishizawa Ken , Kobayashi Shū
Published: August 2023

We describe continuous-flow N-methylation with formaldehyde and H2 using heterogeneous Pd catalysts as a green synthetic method to access N-methyl amines.
Harmonization of an incompatible aqueous aldol condensation/oxa-Michael addition/reduction cascade process over a core–shell-structured thermoresponsive catalyst
Authors: Su Yu , Wang Chengyi , Chen Qipeng , Zhu Yuanli , Deng Shaomin , Yang Shoujin , Jin Ronghua , Liu Guohua
Published: August 2023

A core–shell-structured thermoresponsive hydrogel-supported bifunctional catalyst is developed. This catalyst enables a temperature–tuned aldol condensation/oxa-Michael addition/reduction sequential process to access chiral chromanols.
Titanium and titanium oxides at the K- and L-edges: comparing theoretical calculations to X-ray absorption and X-ray emission measurements
Authors: Bzheumikhova Karina , Vinson John , Unterumsberger Rainer , Wansleben Malte , Zech Claudia , Schüler Kai , Kayser Yves , Hönicke Philipp , Beckhoff Burkhard
Published: August 2023

Using well-calibrated experimental data we demonstrate the applicability of theoretical XAS and XES calculations for Ti, TiO, and TiO2 at the Ti K and L edges as well as O K edge.
Hollow and mesoporous M@aluminosilicate (M = Rh, Pd and Pt) bifunctional catalytic nanoreactors for the hydrodeoxygenation of lignin-derived phenols
Authors: Yu Hongbo , Zhang Fei , Wang Shuibo , Cong Yang , Wang Shiwei , Zhu Lin
Published: August 2023

The high hydrodeoxygenation activity of Rh@Al2.0–mSiO2 could be attributable to the synergistic effect between the metallic Rh and Lewis and Brønsted acid sites.
4-Hydroxybenzoato-rare earth(iii) complexes – syntheses, a structural goldmine from coordination diversity and improved corrosion inhibition behaviour
Authors: Moon Josh , Guo Zhifang , Beaumont Owen A. , Hamilton Sophie , Bousrez Guillaume , Mottram Eleanor , Wang Jun , Somers Anthony E. , Deacon Glen B. , Junk Peter C.
Published: August 2023

A range of rare earth(iii) 4-hydroxybenzoato (4hob) complexes has been prepared and structurally characterized. The La, Ce and Y complexes are good corrosion inhibitors for mild steel.
Ni-doped Al2O3 sensor for effective SO3 gas adsorption and sensing
Authors: Manikandan V. , Ayyannan G. , Petrila Iulian , Mane Rajaram S. , Sobczak Kamil , Chandrasekaran J. , Crapnell Robert D. , Banks Craig E.
Published: August 2023

Ni-doped alumina nanoflakes are a potent sensing material for SO3 gas at 20–90 °C with moderate recovery.
Tuning the surface structure of Cu2O@Pt for enhanced ethanol electrooxidation
Authors: Li Xiang , Zhang Junjun , Xi Bo , Liu Yaming , Jin Changqing , Feng Xiaohua , Liu Ge
Published: August 2023

The Cu2O@Pt nanocatalysts were synthesized by galvanic replacement reaction between copper and platinum ions for enhanced ethanol oxidation reaction.
Conformational flexibility of the disaccharide β-l-Fucp-(1→4)-α-d-Glcp-OMe as deduced from NMR spectroscopy experiments and computer simulations
Authors: Plazinski Wojciech , Angles d'Ortoli Thibault , Widmalm Göran
Published: August 2023

Quantum mechanics methodology was used to calculate solution-state NMR observables such as transglycosidic 3JCH coupling constants, and 1H and 13C NMR chemical shifts in excellent agreement with experimental data for a flexible disaccharide.
A robust fully bio-based aromatic–aliphatic ketone epoxide monomer for high-performance epoxy resin containing an imine structural moiety
Authors: Cao Ziting , You Yang , Li Yunqi , Huang Caijuan , Tian Yaozhu , Zhao Shihao , Chen Qin , Xie Haibo
Published: August 2023

A fully bio-based epoxy monomer with a ketone structure was synthesized and cured with DDM to obtain high-performance epoxy resins containing an imine.
Visible light activated coumarin photocages: an interplay between radical and organobase generation to govern thiol–ene polymerizations
Authors: Kiker Meghan T. , Uddin Ain , Stevens Lynn M. , Chung Kun-You , Lu Pengtao , Page Zachariah A.
Published: August 2023

Novel coumarinylmethyl photobase generators (PBGs) that induce polymerization upon exposure to visible light are described. PBG composition governs anionic vs. radical mechanisms, which will lead to disparate polymer topologies and properties.
Prolonged release of an antimicrobial peptide GL13K-loaded thermosensitive hydrogel on a titanium surface improves its antibacterial and anti-inflammatory properties
Authors: Zhou Lin , Xing Yifeng , Ou Yanjin , Ding Jiamin , Han Yu , Lin Dong , Chen Jiang
Published: August 2023

The application of titanium in the orthopedic and dental fields is associated with bacterial infection and chronic inflammation, especially in the early stages after its implantation.
Enhanced removal of toxic Cr(vi) and Pb(ii) from water using carboxylic terminated Ti3C2Tx nanosheets
Authors: Shah Saleem , Mubeen Iqra , Pervaiz Erum , Nasir Habib
Published: August 2023

An extraordinary performance via physiochemical sorption is displayed by carboxylic terminated Ti3C2Tx nanosheets for the removal of Cr(vi) and Pb(ii) pollutants from aqueous media.
Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies
Authors: Eissa Ibrahim H. , Yousef Reda G. , Elkady Hazem , Elkaeed Eslam B. , Alsfouk Aisha A. , Husein Dalal Z. , Ibrahim Ibrahim M. , Elhendawy Mostafa A. , Godfrey Murrell , Metwaly Ahmed M.
Published: August 2023

This study aimed to design anticancer theobromine derivatives inhibiting VEGFR-2.
Low-carbon footprint diluents in solvent extraction for lithium-ion battery recycling
Authors: Ahamed Aboudaye M. , Swoboda Benjamin , Arora Zubin , Lansot Jean Yves , Chagnes Alexandre
Published: August 2023

This study investigated the influence of low-carbon footprint diluents and diluents from petroleum industry on Co(ii), Ni(ii), Mn(ii), Li(i) and Cu(ii) extraction by Cyanex® 272, DEHPA and Acorga® M5640.
Thiol-triggered deconstruction of bifunctional silyl ether terpolymers via an SNAr-triggered cascade
Authors: Brown Christopher M. , Husted Keith E. L. , Wang Yuyan , Kilgallon Landon J. , Shieh Peyton , Zafar Hadiqa , Lundberg David J. , Johnson Jeremiah A.
Published: August 2023

Thiol-induced nucleophilic aromatic substitution of pentafluorophenyl sidechains is introduced as a strategy for the mild deconstruction of bifunctional silyl ether-containing soluble polymers and crosslinked “thermoset” plastics.
Torsion and bistability of double-twist elastomers
Authors: Leighton Matthew P. , Kreplak Laurent , Rutenberg Andrew D.
Published: August 2023

We study the mechanical properties of double-twist elastomers, a model for collagen fibrils. We find that fibril extension is coupled to torsion, leading to a structural bistability and bifurcation.
Fabrication of triboelectric nanogenerators with multiple strain mechanisms for high-accuracy material and gesture recognition
Authors: Huang Junjun , Zhang Wenqing , Chen Xin , Wang Sanlong , Chen Zhenming , Li Peng , Li Honglin , Gui Chengmei
Published: August 2023

Textile-based triboelectric nanogenerators (T-TENGs) have great potential in new-generation tactile sensors because their output signal is determined by the specific charge interaction between the target and triboelectric material.
Smart design of a therapeutic nanoplatform for mitochondria-targeted copper-depletion therapy combined with chemotherapy
Authors: Hu Taishun , Gong Xiyu , Liu Xinli , Xu Hui , Zhou Fangfang , Tan Songwen , He Yongju
Published: August 2023

A mitochondria-targeted nanoplatform is developed to deplete intracellular copper ions and deliver DOX, consequently achieving prominent efficiency in tumor treatment with a combined copper-depletion therapy and DOX-mediated chemotherapy method.
Aggregation-induced emission mesogens formed by intermolecular hydrogen bonding of 4-alkyl-4′-cyanobiphenyl molecules
Authors: Chou Po-Ting , Ho Tsung Yang , Cai Jia-Ying , Lin Huang-Teng , Hsieh Chung-Hung , Chen Chih-Hsin
Published: August 2023

AIE luminogens with liquid crystalline properties at room temperature were formed by introducing intermolecular hydrogen bonding in 4-alkyl 4′-cyanobiphenyl molecules.
Towards bubble-free, centimeter-sized bilayer graphene enabled by backside lamination
Authors: Yan Mingzhi , Gao Xin , Qian Jun , Gao Xiaoyin , Tang Jilin , Wang Yuechen , Wang Yani , Tang Junchuan , Zheng Liming , Jia Kaicheng , Jia Fei , Liu Hongtao , Gao Guanghui , Peng Hailin
Published: August 2023

Bubble-free bilayer graphene has been fabricated by directly dry-laminating the clean backsides of two single graphene layers with designed asymmetric transfer media.
Synthesis of tuneable gold nanostars: the role of adenosine monophosphate
Authors: Fernández-Lodeiro Carlos , Fernández-Lodeiro Javier , Fernández-Lodeiro Adrián , Nuti Silvia , Lodeiro Carlos , LaGrow Alec , Pérez-Juste Ignacio , Pérez-Juste Jorge , Pastoriza-Santos Isabel
Published: August 2023

Gold nanostars with tuneable optical properties are synthesizedviaa seed-mediated approach employing adenosine monophosphate (AMP) as a capping ligand. AMP directs the reduction of the gold salt and mediates the anisotropic nanoparticle growth.
PEDOT and PEDOT:PSS thin-film electrodes: patterning, modification and application in stretchable organic optoelectronic devices
Authors: Wang Yue , Jia Sisi , Zhang Zhitao
Published: August 2023

This review mainly focuses on patterning strategies and modification methods for better electrical and mechanical properties of PEDOT-based thin-film electrodes as well as their applications in stretchable organic optoelectronics.
From a mononuclear FeIIL2 complex to a spin crossover FeII4L6 cage by symmetric ligand architecture modification: insights into the ammonia gas sensing mechanism
Authors: Li Weiyang , Rotaru Aurelian , Wolff Mariusz , Demeshko Serhiy , Meyer Franc , Garcia Yann
Published: August 2023

Two FeII complexes constructed through symmetric ligand architecture modification were utilized to systematically investigate the ammonia gas sensing mechanism through 57Fe Mössbauer spectroscopy.
The magnetic field clock angle departure in the Venusian magnetosheath and its response to IMF rotation
Authors: Xu Qi , Xie Lianghai , Rong Zhaojin , Xu Xiaojun , Wei Yong , Li Lei , Zhang Tielong
Published: August 2023

We investigate the characteristics of interplanetary magnetic field (IMF) draping in the Venusian magnetosheath using both Venus Express (VEX) observations and magnetohydrodynamics simulations. The distributions of magnetosheath field clock angle illustrate the nearly symmetric morphology of draped magnetic field with respect to the solar wind electric field, and the departure of the IMF clock angle is larger at closer distances. Based on VEX data, the sheath field clock angle departures are found to be <45 degrees for 90% of the instances under steady IMF and this parameter can respond almost immediately to the unsteady IMF. We suggest the magnetosheath field just slips around the planet without significant pileup or bending. Our time-dependent simulations indicate that the response time of sheath field to IMF variation is not more than 1 min and it depends on the involved regions of magnetosheath: the timescale in the inner part of magnetosheath adjacent to the induced magnetosphere is longer than that in the outer part. We find this timescale is controlled by the convection velocity in the magnetosheath, emphasizing the magnetohydrodynamic characteristics of the behavior of the sheath field. The finite magnetosheath field clock angle departure and its quick response to IMF variation suggest that the magnetic field clock angle measured within the Venusian magnetosheath can be used as a reasonable proxy for the upstream IMF clock angle.
Biological activity of forest litters in Ukhta City’s Central Park soils (The Komi Republic)
Authors: Kryazheva Ekaterina , Vinogradova Yulia , Shakhtarova Olga , Kholopov Yuri , Lapteva Elena
Published: August 2023

Physicochemical properties and parameters of biological activity of forest litter horizons of illuvial-ferruginous podzols, formed the main part of soil cover of the largest recreational zone of Ukhta city, the G. A. Karchevsky Central Park, have been determined for the first time ever. In the park soils, a change in the basic agrochemical parameters (alkalinization and an increase in the content of available forms of the most important biogens with the exception of organic compounds carbon), the accumulation of heavy metals (up to moderately toxic level according to value of total pollution index) and petroleum hydrocarbons were indicated in comparison with background soils. An increase in soil enzymes (catalase, invertase) activity and a metabolic activity of soil microbial community was established. Based on the spectra of organic substrate consumption (multisubstrate testing method), a higher activity of all microbial functional (trophic) groups, with the exception of bacteria that consume alcohols, hexoses, and amino acids as an energy source, was revealed.
Methodology for urbanized watersheds parameters ascertainment
Authors: Klubov Stepan , Tretyakov Victor , Dmitriev Vasiliy , Nikulina Anna , Kalinayte-Kramer Catherine
Published: August 2023

The paper presents elaborated methodology for Saint Petersburg and its outskirts watersheds parameters ascertainment. The methodology is based on usage of the digital terrain model, which was created as result of topographic maps digitalization. Usage of the most popular global digital terrain models such as SRTM, ASTER GDEM makes difficulties under the conditions of big cities. The models were processed on the base of Earth surface radar mapping. Therefore, the altitude values have distortions due to the radar signal reflection from roofs, structures, trees, scrubs, and so on. Thus, the global models include noisy data. The distortions can lead to mistakes at determination of the watersheds boundaries. Topographic maps digitalization allows elaborating of digital terrain models without distortions of the altitude values. The watersheds boundaries ascertainment was carried out by means of the ArcGIS tool Watershed. In addition, we use for the ascertainment and determination of the catchments areas structure some tools of Quantum GIS (QGIS) and SAGA.
Granulometric, elemental and isotopic composition of bottom sediments of lakes of mountainous areas as a reflection of transformations in their watersheds
Authors: Fedorov Yury A. , Mikhailenko Anna V. , Dotsenko Irina V. , Kovalev Evgeny A. , Chepurnaya Victoria I. , Dotsenko Nicolay V. , Gavrilova Irina Yu. , Bellinger Olga Yu.
Published: August 2023

The article provides a brief description of the geological and tectonic structure and technogenic transformations in the drainage basin of two lakes of the Krasnodar Krai (Malyy Liman and Abrau). They belong to a single natural-technogenic system. On the example of these mountain lakes, the grain-size distribution, elemental (mercury) and isotopic (cesium-137) composition of bottom sediments was studied. The use of a set of methods and technologies, including those developed by the authors, made it possible to determine the parameters of the anthropogenic impact layer in bottom sediments and the chronology of its formation. It is closely related to natural and man-made events in the drainage basin.
Development of artemia resources in the western basin of the Aral sea
Authors: Musaev Ablatdin , Temirbekov Ramatulla , Israilova Irina , Kaliknazarova Almagul
Published: August 2023

Researchers from the Republic of Karakalpakstan are conducting continuous monitoring on the Aral Sea, studying artemia from various perspectives, as it is an interesting object from both a biological and applied perspective. This work is also being carried out jointly with the P.P. Shirshov Institute of Oceanology of the Russian Academy of Sciences. This paper presents the results of long-term comprehensive scientific research conducted on the Aral Sea. The main material for the study was our own collection of hydrobiological samples collected from the Western basin of the Aral Sea. As a result of the research, the dynamics of artemia resource development has been determined.
Production of gamma-aminobutyric acid by lactic acid bacteria of marine origin from Vietnam
Authors: Dinh Thi Thu Trang , Nguyen Cong Tinh , Vo Thi Hoai Thu , Do Thi Thuy , Do Thi Thu Hong
Published: August 2023

Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid, which functions as a neurotransmitter in the central nervous system. GABA has been shown to have several positive effects on human health, including reducing anxiety and promoting relaxation. In this study, various fermented fish products were screened for their ability to produce GABA. A total of 35 acid lactic producing strains were isolated from 8 samples of marine organism, 10 strains were found to have GABA-producing abilities. These strains were identified using 16S rDNA sequencing. The GABA concentrations produced by the 10 isolates ranged from 725 to 5590 mg/L. Lactobacillus brevis GB111 is the best isolated GABA producing strain, with a conversion rate up to 90.3%, which suggests that these strains may have potential applications in the food and pharmaceutical industries as a source of GABA.
Environmental management implementation in wastewater treatment at a machine-building enterprise: From theory to practice
Authors: Bosiuk Alona , Filenko Olesya , Shkop Andrii , Kulinicn Serhii , Tykhomyrova Tetiana , Shestopalov Oleksіi
Published: August 2023

This study examines environmental management implementation in the context of wastewater treatment at machine-building enterprises. The article aims to assess how effectively environmental management is used in the wastewater treatment system to ensure rational resource use. It is noted that wastewater contains a significant amount of various pollutants that must be removed before disposal. A wastewater samples analysis was carried out to assess the environmental management implementation’s effectiveness. The changes in the concentration of the pollutants during three months were found: the hydrogen indicator decreased from 7.83 mg/dm3 to 7.58 mg/dm3. The oil product concentration increased from 22.2 mg/dm3 to 3.4 mg/dm3, while the fat concentration remained stable. The received results provide important information for improving the wastewater treatment system and environmental management implementation. To ensure environmental safety and compliance with environmental standards, it is necessary to implement environmental management in wastewater treatment at machine-building enterprises. The optimal wastewater treatment technology choice and monitoring program development are described. The article contains practical recommendations for the implementation of environmental management at a machine-building enterprise and a perspective on this direction of development. The research is relevant and useful for machine-building complexes that have problems with wastewater treatment and aim to implement environmental management.
Synergetic approach for sustainable public service personnel management during Covid-19
Authors: Рodolchak Nazar , Karkovska Veronika , Tsygylyk Natalia , Dziurakh Yurii , Bilyk Olena
Published: August 2023

The paper explores the application of a synergetic approach in managing public service personnel in a developing country, utilizing methods such as the six thinking hats, Delphi, analysis and synthesis, deductive, and Stanford model design thinking. It analyses sustainable development indicators, changes in personnel management within government bodies, and highlights a HDI of 0.779, Corruption Perceptions Index of 32, Income Inequality Index of 25.36%, and Gender Equality Index ranging from 0.677 to 0.714 in 2021. The findings suggest measures to activate synergetic principles, including enhancing critical and creative thinking, emotional intelligence, IQ, stress resistance, and knowledge among managers, as well as emphasizing emotional intelligence and IQ among organizational personnel. Steps for HR management in the Ukrainian public service are proposed, such as adaptation, motivation improvement, exit interviews, corporate culture development, competitive wages, and remote HRMIS technology utilization.
Smart projects on the development of green intellectual capital in eco-industrial parks
Authors: Mikhno Inesa , Koval Viktor , Khaustova Yevheniia , Järvis Marina , Gudz Petro , Gudz Maryna , Kostiukov Viacheslav
Published: August 2023

The study examines problems related to excessive environmental pressure on the ecosystem caused by industrial activities. It suggests constructing eco-industrial parks to optimize production and natural resources, monitor the condition of environmental safety in a limited territory with a developed infrastructure, and create green intellectual capital. The approach to the maximum automation of territories and introducing startups for the continuous modernization of the production and landscape park as part of the eco-industrial park is substantiated. It is proven that smart projects on the development of green intellectual capital based on eco-industrial parks will positively affect their implementation, can become a promising project for foreign investors, and can enhance the environmental safety of settlements. According to the model, for a settlement with a population of 1,500 people that works in an eco-industrial park, the utility function per person will increase by 12% when building a joint system of innovative ecological production and increasing the level of the country’s green capital.
Association between physical activity and body mass index with sociodemographic factors among public school teachers in Iraqi Kurdistan Region
Authors: Yahya Abdullah Rebar , Ibrahim Radhwan Hussein
Published: August 2023

Background: Physical activity (PA) is a significant element in people’s daily life and leads to long-term health benefits. However, inadequate physical activity, obesity, and being overweight are the main risk factors that contribute to non-communicable diseases (NCDs). This study aimed to examine the association between physical activity and body mass index (BMI) among public school teachers in the Iraqi Kurdistan Region. Methods: The cross-sectional study design was applied from September 15th, 2021, to April 1st, 2022. Stratified-simple random sampling was employed to select 500 school teachers aged from 18 to 64. The current study used a questionnaire and was composed of two parts: the first part included sociodemographic characteristics and BMI, and the second part consisted of measuring physical activity assessments using the International Physical Activity Questionnaire-Long (IPAQ-L). Results: The majority of teachers (38.6%) were between the ages of 30 and 39, and 64.8% were female. The combined prevalence of overweight and obesity was 71.4%. The vast majority of school teachers (65.8%) had a low level of physical activity, which was significantly linked with gender (P < 0.001), marital status (P < 0.001), educational level (P = 0.008), and monthly income (P = 0.006). There was a significant relationship between physical activity and body mass index, which was inversely related to body mass index (P < 0.001). In addition, teachers with a healthy BMI were more physically active than those with a high BMI. Conclusion: The vast majority of teachers failed to meet international recommendations on PA. Moreover, it was shown that there is a significant association between physical activity and body weight. When physical activity increases, BMI will decrease.
Diabetes-Technologie und Digitalisierung in der stationären Diabetologie: Time to act
Authors: Tan Susanne , Heinemann Lutz , Kordonouri Olga , Lobmann Ralf , Menzen Markus , Raile Klemens , Werner Thomas , Kulzer Bernhard
Published: August 2023

In Deutschland sind 304 stationäre Einrichtungen (inkl. 74 Pädiatrien) auf die Versorgung von Menschen mit Diabetes spezialisiert. Die Mehrheit der Diabetolog:innen DDG (2.521/4.267, 59%) ist im Krankenhaus tätig 11. Die stationäre Diabetologie steht vor vielfältigen Herausforderungen: schwierige finanzielle Rahmenbedingungen, ein unzureichendes Bewusstsein für die Relevanz von Diabetes auf die Gesundheit der Patient:innen im stationären Setting, inkonsequente Diabetestherapie, prozessuale Hindernisse und eine abnehmende Anzahl an ausbildenden Kliniken. Die fortschreitende Digitalisierung und Verfügbarkeit neuer Diabetestechnologien eröffnet ein neues Feld an Herausforderungen und bietet jedoch gleichzeitig die Chance, Diabetesmanagement im Krankenhaus neu zu gestalten und die alten Probleme mit neuen Mitteln zu lösen. Ziel dieses Positionspapiers ist es, die komplexe Situation, die Vielfalt offener Themen und die besonderen Chancen der Diabetestechnologie zu umreißen und so eine Diskussion für eine Plattform für Diabetolog:innen des stationären Sektors und eine holistische Strategie des digitalisierten Diabetesmangements zur Optimierung und Sicherung der stationären Diabetesversorgung anzuregen.
Spezialisierte Physiotherapie bei funktionellen Bewegungsstörungen
Authors: Degen-Plöger Christof , Reincke Annemarie , Fasching Bernhard , Lüdtke Kerstin
Published: August 2023

Die Physiotherapie bei funktionellen Bewegungsstörungen unterscheidet sich erheblich von einer konventionellen neurologisch ausgerichteten Physiotherapie. Sie folgt einem kognitiv-verhaltenstherapeutischem Ansatz, im Sinne einer psychologisch informierten Physiotherapie. Dabei werden multiple Faktoren in den Therapieprozess mit einbezogen, welche anhand des bio-psycho-sozialen Modells erhoben werden, um die hintergründigen Symptomtrigger und -modulatoren zu eruieren. Sie zielt darauf ab, dass der betroffene Patient das Krankheitsbild versteht und akzeptiert sowie den Therapieinhalten Bedeutung beimessen kann. Das Erarbeiten einer bewussten Aufmerksamkeitslenkung (Strategie), weg von der eigentlichen funktionellen Störung, ist ein zentraler Bestandteil. Diese erfolgt über die Nutzung unserer Sinnesreize, Verlagerung des Fokus auf intakte Bewegungsmuster, zielorientierten Handlungen sowie dem Einsatz einer bewussten Sprache. Das Selbstmanagement im Umgang mit beeinflussenden Faktoren, der Aufbau einer Toleranz gegenüber solchen und ein allgemein gesundheitsförderndes Verhalten runden die Therapie ab. Im vorliegenden Artikel stellen wir diesen Therapieansatz, welcher in Deutschland erstmalig im ambulanten Setting innerhalb einer Studie erprobt wird, vor und geben Empfehlungen für die Praxis.
Multimodale Therapie funktioneller Bewegungsstörungen im stationären Setting
Authors: Schmidt Tamara , Ebersbach Georg
Published: August 2023

Die multimodale, stationäre Therapie funktioneller Bewegungsstörungen ist eine kaum etablierte Aufgabe für neurologische Kliniken. Besondere Herausforderungen ergeben sich aus den strukturellen Voraussetzungen (multimodales Therapieangebot mit entsprechender fachlicher Expertise) und den teils langwierigen und komplexen therapeutischen Prozessen. In diesem Beitrag wird ein in Beelitz-Heilstätten entwickeltes und seit Jahren klinisch erprobtes Behandlungskonzept exemplarisch dargestellt. Die Vergütung innerhalb des DRG-Systems und Indikationskriterien für eine Behandlung von funktionellen Bewegungsstörungen im stationären neurologischen Setting werden erläutert.
Müde Mitochondrien
Authors: Feldhaus Simon
Published: August 2023

Anhand des vorliegenden Fallbeispiels veranschaulicht der Autor, wie bestimmte Virusinfektionen ein – häufig fehldiagnostiziertes – postvirales Fatigue-Syndrom nach sich ziehen können. Zu den Kardinalsymptomen gehören körperliche und geistige Erschöpfung und gesteigerte Ermüdbarkeit, begleitet von unter anderem Muskelschmerzen, Gedächtnis- sowie anderen kognitiven Störungen. Eine häufige Ursache ist eine Mitochondriopathie. Sie kann nach einer Funktionstestung der Mitochondrien individuell und kausal mit orthomolekularer Medizin behandelt werden.