bluuebunny/crossref_metadata_2025 huggingface dataset:
A Holistic Model of Care to Support Those Living with and beyond Cancer
Authors: Cadet Tamara , Davis Cindy , Elks Jacinta , Wilson Patricia
Published: November 2016

Background: Globally, the burden of cancer continues to increase and it is well-documented that while not a homogeneous population, cancer patients and cancer survivors face many physical, psychological, social, spiritual, and financial issues. Cancer care is shifting from a disease-focused to a patient-centered approach resulting in an increased need to address these concerns. Methods: Utilizing a quality improvement approach, this paper describes an integrated cancer care model at Bloomhill Cancer Center (BCC) in Queensland, Australia that demonstrates the ability to meet the holistic needs of patients living with and beyond cancer and to identify opportunities for better practice and service provision. Results: Survey results indicate that 67% and 77% of respondents were very satisfied and 27% and 17% were satisfied with their first contact and very satisfied with their first meeting with a nurse at BCC. Clients also reported being very satisfied (46%) or satisfied (30%) with the emotional support they received at BCC and over 90% were very satisfied or satisfied with the touch therapies that the received. Conclusion: Due to the early success of the interventions provided by BCC, the model potentially offers other states and countries a framework for supportive cancer care provision for people living with and beyond cancer.
Adoption and Income Effects of Public GAP Standards: Evidence from the Horticultural Sector in Thailand
Authors: Krause Henning , Lippe Rattiya , Grote Ulrike
Published: November 2016

To reduce potential food hazards and increase the image of Thai horticultural products abroad, the Thai government introduced public standards of Good Agricultural Practices (Q-GAP). What makes orchid and mango producers in Thailand adopt Q-GAP standards and how do these affect their income and export shares? Primary data from 400 certified and non-certified orchid and mango producers was collected from main exporting provinces in Thailand. The binary probit model estimations show that it is the orchid and mango producers with higher education, and more physical and social capital who tend to comply with Q-GAP standards. Results from the Propensity Score Matching approach reveal that adoption of public GAP standards results in positive income effects for mango producers, but not for orchid producers. This can be explained by the fact that certified mango producers can sell their products to high-value retail chains which offer higher prices for their products, while certified and non-certified orchid producers cooperate with traders from the same value chain.
2015 Disastrous Floods in Louisiana, USA, and Assam, India: Groundwater Impact on the Water Balance Estimation
Authors: Trifonova Tatiana , Trifonov Dmitriy , Arakelian Sergey
Published: November 2016

Traditionally torrential rains are considered as the main factor of flood emergence. With the examples of two disastrous floods in 2015 in absolutely different parts of the world, the authors roughly estimate the water balance and suggest an alternative hypothesis. The simplest model, taking into account precipitation, evaporation and soil permeability, clearly points out the significant discrepancy between potentially accumulated and observed water masses. This observation pushes the idea that precipitation is necessary but not sufficient for disastrous flood emergence, so the only other available water source—groundwater—cannot be ignored.
Respiratory Diseases in University Students Associated with Exposure to Residential Dampness or Mold
Authors: Lanthier-Veilleux Mathieu , Baron Geneviève , Généreux Mélissa
Published: November 2016

University students are frequently exposed to residential dampness or mold (i.e., visible mold, mold odor, dampness, or water leaks), a well-known contributor to asthma, allergic rhinitis, and respiratory infections. This study aims to: (a) describe the prevalence of these respiratory diseases among university students; and (b) examine the independent contribution of residential dampness or mold to these diseases. An online survey was conducted in March 2014 among the 26,676 students registered at the Université de Sherbrooke (Quebec, Canada). Validated questions and scores were used to assess self-reported respiratory diseases (i.e., asthma-like symptoms, allergic rhinitis, and respiratory infections), residential dampness or mold, and covariates (e.g., student characteristics). Using logistic regressions, the crude and adjusted odd ratios between residential dampness or mold and self-reported respiratory diseases were examined. Results from the participating students (n = 2097; response rate: 8.1%) showed high prevalence of allergic rhinitis (32.6%; 95% CI: 30.6–34.7), asthma-like symptoms (24.0%; 95% CI: 22.1–25.8) and respiratory infections (19.4%; 95% CI: 17.7–21.2). After adjustment, exposure to residential dampness or mold was associated with allergic rhinitis (OR: 1.25; 95% CI: 1.01–1.55) and asthma-like symptoms (OR: 1.70; 95% CI: 1.37–2.11), but not with respiratory infections (OR: 1.07; 95% CI: 0.85–1.36). Among symptomatic students, this exposure was also associated with uncontrolled and burdensome respiratory symptoms (p < 0.01). University students report a high prevalence of allergic rhinitis, asthma-like symptoms and respiratory infections. A common indoor hazard, residential dampness or mold, may play a role in increasing atopic respiratory diseases and their suboptimal control in young adults. These results emphasize the importance for public health organizations to tackle poor housing conditions, especially amongst university students who should be considered “at-risk”.
Toosendanin Exerts an Anti-Cancer Effect in Glioblastoma by Inducing Estrogen Receptor β- and p53-Mediated Apoptosis
Authors: Cao Liang , Qu Dingding , Wang Huan , Zhang Sha , Jia Chenming , Shi Zixuan , Wang Zongren , Zhang Jian , Ma Jing
Published: November 2016

Glioblastoma (GBM) is the most common primary brain tumor with median survival of approximately one year. This dismal poor prognosis is due to resistance to currently available chemotherapeutics; therefore, new cytotoxic agents are urgently needed. In the present study, we reported the cytotoxicity of toosendanin (TSN) in the GBM U87 and C6 cell lines in vitro and in vivo. By using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay, flow cytometry analysis, and Western blot, we found that TSN inhibited U87 and C6 cell proliferation and induced apoptosis at a concentration as low as 10 nM. Administration of TSN also reduced tumor burden in a xenograft model of athymic nude mice. Pharmacological and molecular studies suggested that estrogen receptor β (ERβ) and p53 were prominent targets for TSN. GBM cell apoptosis induced by TSN was a stepwise biological event involving the upregulation of ERβ and contextual activation of functional p53. Collectively, our study indicates, for the first time, that TSN is a candidate of novel anti-cancer drugs for GBM. Furthermore, ERβ and p53 could act as predictive biomarkers for the sensitivity of cancer to TSN.
The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death
Authors: Zhong Rui , Xin Rui , Chen Zongyan , Liang Nan , Liu Yang , Ma Shumei , Liu Xiaodong
Published: November 2016

Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs. dCK is activated in response to ionizing radiation (IR)-induced DNA damage and it is phosphorylated on Serine 74 by the Ataxia-Telangiectasia Mutated (ATM) kinase in order to activate the cell cycle G2/M checkpoint. However, whether dCK plays a role in radiation-induced cell death is less clear. In this study, we genetically modified dCK expression by knocking down or expressing a WT (wild-type), S74A (abrogates phosphorylation) and S74E (mimics phosphorylation) of dCK. We found that dCK could decrease IR-induced total cell death and apoptosis. Moreover, dCK increased IR-induced autophagy and dCK-S74 is required for it. Western blotting showed that the ratio of phospho-Akt/Akt, phospho-mTOR/mTOR, phospho-P70S6K/P70S6K significantly decreased in dCK-WT and dCK-S74E cells than that in dCK-S74A cells following IR treatment. Reciprocal experiment by co-immunoprecipitation showed that mTOR can interact with wild-type dCK. IR increased polyploidy and decreased G2/M arrest in dCK knock-down cells as compared with control cells. Taken together, phosphorylated and activated dCK can inhibit IR-induced cell death including apoptosis and mitotic catastrophe, and promote IR-induced autophagy through PI3K/Akt/mTOR pathway.
Zebrafish: A Model for the Study of Toxicants Affecting Muscle Development and Function
Authors: Dubińska-Magiera Magda , Daczewska Małgorzata , Lewicka Anna , Migocka-Patrzałek Marta , Niedbalska-Tarnowska Joanna , Jagla Krzysztof
Published: November 2016

The rapid progress in medicine, agriculture, and allied sciences has enabled the development of a large amount of potentially useful bioactive compounds, such as drugs and pesticides. However, there is another side of this phenomenon, which includes side effects and environmental pollution. To avoid or minimize the uncontrollable consequences of using the newly developed compounds, researchers seek a quick and effective means of their evaluation. In achieving this goal, the zebrafish (Danio rerio) has proven to be a highly useful tool, mostly because of its fast growth and development, as well as the ability to absorb the molecules diluted in water through its skin and gills. In this review, we focus on the reports concerning the application of zebrafish as a model for assessing the impact of toxicants on skeletal muscles, which share many structural and functional similarities among vertebrates, including zebrafish and humans.
Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass
Authors: Salameh Aida , Dhein Stefan , Dähnert Ingo , Klein Norbert
Published: November 2016

Aortocoronary bypass or valve surgery usually require cardiac arrest using cardioplegic solutions. Although, in principle, in a number of cases beating heart surgery (so-called off-pump technique) is possible, aortic or valve surgery or correction of congenital heart diseases mostly require cardiopulmonary arrest. During this condition, the heart-lung machine also named cardiopulmonary bypass (CPB) has to take over the circulation. It is noteworthy that the invention of a machine bypassing the heart and lungs enabled complex cardiac operations, but possible negative effects of the CPB on other organs, especially the brain, cannot be neglected. Thus, neuroprotection during CPB is still a matter of great interest. In this review, we will describe the impact of CPB on the brain and focus on pharmacological and non-pharmacological strategies to protect the brain.
Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran
Authors: Abutarboush Rania , Saha Biswajit , Mullah Saad , Arnaud Francoise , Haque Ashraful , Aligbe Chioma , Pappas Georgina , Auker Charles , McCarron Richard , Moon-Massat Paula , Scultetus Anke
Published: November 2016

Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50–100 μm) showed minor (~8–9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend.
Climate Change Impacts on Future Wave Climate around the UK
Authors: Bennett William , Karunarathna Harshinie , Mori Nobuhito , Reeve Dominic
Published: November 2016

Understanding the changes in future storm wave climate is crucial for coastal managers and planners to make informed decisions required for sustainable coastal management and for the renewable energy industry. To investigate potential future changes to storm climate around the UK, global wave model outputs of two time slice experiments were analysed with 1979–2009 representing present conditions and 2075–2100 representing the future climate. Three WaveNet buoy sites around the United Kingdom, which represent diverse site conditions and have long datasets, were chosen for this study. A storm event definition (Dissanayake et al., 2015) was used to separate meteorologically-independent storm events from wave data, which in turn allowed storm wave characteristics to be analysed. Model outputs were validated through a comparison of the modelled storm data with observed storm data for overlapping periods. Although no consistent trends across all future clusters were observed, there were no significant increases in storm wave height, storm count or storm power in the future, at least according to the global wave projection results provided by the chosen model.
Tidal Datum Changes Induced by Morphological Changes of North Carolina Coastal Inlets
Authors: Wang Jindong , Myers Edward
Published: November 2016

In support of the National Oceanic and Atmospheric Administration’s VDatum program, a new version of a tidal datum product for the North Carolina coastal waters has been developed to replace the initial version released in 2004. Compared with the initial version, the new version used a higher resolution grid to cover more areas and incorporated up-to-date tide, bathymetry, and shoreline data. Particularly, the old bathymetry datasets that were collected from the 1930s to the 1970s and were used in the initial version have been replaced by the new bathymetry datasets collected in the 2010s in the new version around five North Carolina inlets. This study aims at evaluating and quantifying tidal datum changes induced by morphological changes over about 40 to 80 years around the inlets. A series of tidal simulations with either the old or new bathymetry datasets used around five inlets were conducted to quantify the consequent tidal datum changes. The results showed that around certain inlets, approximately 10% change in the averaged depth could result in over 30% change in the tidal datum magnitude. Further investigation also revealed that tidal datum changes behind the barrier islands are closely associated with the cross-inlet tidal flux changes.
Potential Synthetic Biolubricant as an Alternative to Bovine Serum
Authors: Scholes Susan , Colledge Coral , Naylor Andrew , Mahdi Mohammed , Smith Alan , Joyce Thomas
Published: November 2016

It is crucial that orthopaedic implant materials are tested in conditions that replicate the natural body’s environment as closely as possible. Bovine serum is currently recommended for use by the International Organisation for Standardisation (ISO) for the wear testing of these implant materials, however, the rheological properties of bovine serum do not match fully those of the body’s natural lubricant, synovial fluid. This study looks at a potential alternative to bovine serum for the testing of orthopaedic implant materials; 0.5% gellan gum fluid gel. Wear tests using multidirectional motion were conducted on ultra-high molecular weight polyethylene (UHMWPE) pins rubbing against stainless steel plates. Roughness measurements were performed during testing along with particle analysis of the testing lubricant. At two million cycles (equivalent to 121.3 km of sliding), the mean wear factor for the four UHMWPE pins was 0.25 (standard deviation (SD) 0.03) × 10−6 mm3/Nm and there was no evidence of any transfer film on the plate surfaces. The wear factor produced by 0.5% gellan gum fluid gel was lower than that measured in previous studies using bovine serum as the lubricant but greater than the wear factor shown in published work using a similar alternative lubricant (sodium alginate mixed with gellan gum). Work on the development of a suitable alternative lubricant to bovine serum will continue.
Characterization and Bioactivity Evaluation of (Polyetheretherketone/Polyglycolicacid)-Hydroyapatite Scaffolds for Tissue Regeneration
Authors: Shuai Cijun , Shuai Chenying , Wu Ping , Yuan Fulai , Feng Pei , Yang Youwen , Guo Wang , Fan Xiaohan , Su Ting , Peng Shuping , Gao Chengde
Published: November 2016

Bioactivity and biocompatibility are crucial for tissue engineering scaffolds. In this study, hydroxyapatite (HAP) was incorporated into polyetheretherketone/polyglycolicacid (PEEK/PGA) hybrid to improve its biological properties, and the composite scaffolds were developed via selective laser sintering (SLS). The effects of HAP on physical and chemical properties of the composite scaffolds were investigated. The results demonstrated that HAP particles were distributed evenly in PEEK/PGA matrix when its content was no more than 10 wt %. Furthermore, the apatite-forming ability became better with increasing HAP content after immersing in simulated body fluid (SBF). Meanwhile, the composite scaffolds presented a greater degree of cell attachment and proliferation than PEEK/PGA scaffolds. These results highlighted the potential of (PEEK/PGA)-HAP scaffolds for tissue regeneration.
Effects of Acoustic Modulation and Mixed Fuel on Flame Synthesis of Carbon Nanomaterials in an Atmospheric Environment
Authors: Hu Wei-Chieh , Sari Shanti , Hou Shuhn-Shyurng , Lin Ta-Hui
Published: November 2016

In this study, methane–ethylene jet diffusion flames modulated by acoustic excitation in an atmospheric environment were used to investigate the effects of acoustic excitation frequency and mixed fuel on nanomaterial formation. Acoustic output power was maintained at a constant value of 10 W, while the acoustic excitation frequency was varied (f = 0–90 Hz). The results show that the flame could not be stabilized on the port when the ethylene volume concentration (ΩE) was less than 40% at f = 10 Hz, or when ΩE = 0% (i.e., pure methane) at f = 90 Hz. The reason for this is that the flame had a low intensity and was extinguished by the entrained air due to acoustic modulation. Without acoustic excitation (f = 0 Hz), the flame was comprised of a single-layer structure for all values of ΩE, and almost no carbon nanomaterials were synthesized. However, with acoustic excitation, a double-layer flame structure was generated for frequencies close to both the natural flickering frequency and the acoustically resonant frequency. This double-layer flame structure provided a favorable flame environment for the fabrication of carbon nanomaterials. Consequently, the synthesis of carbon nano-onions was significantly enhanced by acoustic excitation near both the natural flickering frequency and the acoustically resonant frequency. At f = 20 Hz (near the natural flickering frequency) for 0% ≤ ΩE ≤ 100%, a quantity of carbon nano-onions (CNOs) piled like bunches of grapes was obtained as a result of improved mixing of the fuel with ambient air. High-density CNOs were also produced at f = 70 Hz (close to the acoustically resonant frequency) for 40% ≤ ΩE ≤ 100%. Furthermore, carbon nanotubes (CNTs) were synthesized only at 80 Hz for ΩE = 0%. The suitable temperature range for the synthesis of CNTs was slightly higher than that for the formation of CNOs (about 600 °C for CNTs; 510–600 °C for CNOs).
Numerical Approach to Modeling and Characterization of Refractive Index Changes for a Long-Period Fiber Grating Fabricated by Femtosecond Laser
Authors: Saad Akram , Cho Yonghyun , Ahmed Farid , Jun Martin
Published: November 2016

A 3D finite element model constructed to predict the intensity-dependent refractive index profile induced by femtosecond laser radiation is presented. A fiber core irradiated by a pulsed laser is modeled as a cylinder subject to predefined boundary conditions using COMSOL5.2 Multiphysics commercial package. The numerically obtained refractive index change is used to numerically design and experimentally fabricate long-period fiber grating (LPFG) in pure silica core single-mode fiber employing identical laser conditions. To reduce the high computational requirements, the beam envelope method approach is utilized in the aforementioned numerical models. The number of periods, grating length, and grating period considered in this work are numerically quantified. The numerically obtained spectral growth of the modeled LPFG seems to be consistent with the transmission of the experimentally fabricated LPFG single mode fiber. The sensing capabilities of the modeled LPFG are tested by varying the refractive index of the surrounding medium. The numerically obtained spectrum corresponding to the varied refractive index shows good agreement with the experimental findings.
Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides—A Review
Authors: Jensen Ida-Johanne , Mæhre Hanne
Published: November 2016

High seafood consumption has traditionally been linked to a reduced risk of cardiovascular diseases, mainly due to the lipid lowering effects of the long chained omega 3 fatty acids. However, fish and seafood are also excellent sources of good quality proteins and emerging documentation show that, upon digestion, these proteins are sources for bioactive peptides with documented favorable physiological effects such as antioxidative, antihypertensive and other cardioprotective effects. This documentation is mainly from in vitro studies, but also animal studies are arising. Evidence from human studies evaluating the positive health effects of marine proteins and peptides are scarce. In one study, a reduction in oxidative stress after intake of cod has been documented and a few human clinical trials have been performed evaluating the effect on blood pressure. The results are, however, inconclusive. The majority of the human clinical trials performed to investigate positive health effects of marine protein and lean fish intake, has focused on blood lipids. While some studies have documented a reduction in triglycerides after intake of lean fish, others have documented no effects.
Microstructure and Wear Properties of Electron Beam Melted Ti-6Al-4V Parts: A Comparison Study against As-Cast Form
Authors: Toh Wei , Wang Pan , Tan Xipeng , Nai Mui , Liu Erjia , Tor Shu
Published: November 2016

Ti-6Al-4V (Ti64) parts of varying thicknesses were additively manufactured (AM) by the powder-bed-based electron beam melting (EBM) technique. Microstructure and wear properties of these EBM-built Ti-6Al-4V parts have been investigated in comparison with conventionally cast Ti64 samples. Sliding wear tests were conducted using a ball-on-disc micro-tribometer under ambient conditions. Experimental results reveal that EBM-built Ti64 samples exhibited higher microhardness and an overall larger coefficient of friction as compared to the as-cast counterpart. Of interest is that the corresponding specific wear volumes were lower for EBM-built Ti64 samples, while the as-cast Ti64 showed the poorest wear resistance despite its lower coefficient of friction. Wear mechanisms were provided in terms of quantitative microstructural characterization and detailed analysis on coefficient of friction (COF) curves.
An Investigation of the Mechanical Properties of a Weldment of 7% Nickel Alloy Steels
Authors: Park Jeong , Lee Jae , Kim Myung
Published: November 2016

During the last decade, the demand for natural gas has steadily increased for the prevention of environmental pollution. For this reason, many liquefied natural gas (LNG) carriers have been manufactured. Since one of the most important issues in the design of LNG carriers is to guarantee structural safety, the use of low-temperature materials is increasing. Among commonly employed low-temperature materials, nickel steel has many benefits such as good strength and outstanding corrosion resistance. Accordingly, nickel steels are one of the most commonly used low-temperature steels for LNG storage tanks. However, the study of fracture toughness with various welding consumables of 7% nickel alloy steel is insufficient for ensuring the structural safety of LNG storage tanks. Therefore, the aim of this study was to evaluate fracture toughness of several different weldments for 7% nickel alloy steels. The weldment of 7% nickel alloy steel was fabricated by tungsten inert gas (TIG), flux cored arc welding (FCAW), and gas metal arc welding (GMAW). In order to assess the material performance of the weldments at low temperature, fracture toughness such as crack tip opening displacement (CTOD) and the absorbed impact energy of weldments were compared with those of 9% nickel steel weldments.
EPS—Then and Now
Authors: Flemming Hans-Curt
Published: November 2016

“Slime” played a brief and spectacular role in the 19th century founded by the theory of primordial slime by Ernst Haeckel. However, that substance was never found and eventually abandoned. Further scientific attention slowly began in the 1930s referring to slime as a microbial product and then was inspired by “How bacteria stick” by Costerton et al. in 1978, and the matrix material was considered to be polysaccharides. Later, it turned out that proteins, nucleic acids and lipids were major other constituents of the extracellular polymeric substances (EPS), an acronym which was highly discussed. The role of the EPS matrix turns out to be fundamental for biofilms, in terms of keeping cells in proximity and allowing for extended interaction, resource capture, mechanical strength and other properties, which emerge from the life of biofilm organisms, including enhanced tolerance to antimicrobials and other stress. The EPS components are extremely complex and dynamic and fulfil many functional roles, turning biofilms into the most ubiquitous and successful form of life on Earth.
The Combined Application of the Caco-2 Cell Bioassay Coupled with In Vivo (Gallus gallus) Feeding Trial Represents an Effective Approach to Predicting Fe Bioavailability in Humans
Authors: Tako Elad , Bar Haim , Glahn Raymond
Published: November 2016

Research methods that predict Fe bioavailability for humans can be extremely useful in evaluating food fortification strategies, developing Fe-biofortified enhanced staple food crops and assessing the Fe bioavailability of meal plans that include such crops. In this review, research from four recent poultry (Gallus gallus) feeding trials coupled with in vitro analyses of Fe-biofortified crops will be compared to the parallel human efficacy studies which used the same varieties and harvests of the Fe-biofortified crops. Similar to the human studies, these trials were aimed to assess the potential effects of regular consumption of these enhanced staple crops on maintenance or improvement of iron status. The results demonstrate a strong agreement between the in vitro/in vivo screening approach and the parallel human studies. These observations therefore indicate that the in vitro/Caco-2 cell and Gallus gallus models can be integral tools to develop varieties of staple food crops and predict their effect on iron status in humans. The cost-effectiveness of this approach also means that it can be used to monitor the nutritional stability of the Fe-biofortified crop once a variety has released and integrated into the food system. These screening tools therefore represent a significant advancement to the field for crop development and can be applied to ensure the sustainability of the biofortification approach.
Inflammatory Properties of Diet and Glucose-Insulin Homeostasis in a Cohort of Iranian Adults
Authors: Moslehi Nazanin , Ehsani Behnaz , Mirmiran Parvin , Shivappa Nitin , Tohidi Maryam , Hébert James , Azizi Fereidoun
Published: November 2016

We aimed to investigate associations of the dietary inflammatory index (DII) with glucose-insulin homeostasis markers, and the risk of glucose intolerance. This cross-sectional study included 2975 adults from the Tehran Lipid and Glucose Study. Fasting plasma glucose (FPG), 2-h post-load glucose (2h-PG), and fasting serum insulin were measured. Homeostatic model assessment of insulin resistance index (HOMA-IR) and β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) were calculated. Glucose tolerance abnormalities included impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2DM). DII scores were positively associated with 2h-PG (β = 0.04; p = 0.05). There was no significant linear trend across quartiles of DII for adjusted means of glucose-insulin homeostasis markers. Participants in the highest quartile of DII score tended to have higher FPG compared to those in the second quartile of DII score (5.46 vs. 5.38 mmol/L, p = 0.07) and higher fasting insulin and HOMA-IR compared to those in the lowest quartile (8.52 vs. 8.12 µU/mL for fasting insulin, p = 0.07; 2.06 vs. 1.96 for HOMA-IR, p = 0.08). No significant associations were observed between DII and risk of IFG, IGT, T2DM, and insulin resistance. Among glucose-insulin homeostasis markers, DII had a positive weak association only with 2h-PG.
Beverage Consumption Habits around the World: The Burden of Disease Attributable to Hydration
Authors: Serra-Majem Lluis , Nissensohn Mariela
Published: November 2016

Dehydration occurs when the body loses more water than is taken in.[...]
Dietary Intake, Body Composition, and Menstrual Cycle Changes during Competition Preparation and Recovery in a Drug-Free Figure Competitor: A Case Study
Authors: Halliday Tanya , Loenneke Jeremy , Davy Brenda
Published: November 2016

Physique competitions are events in which competitors are judged on muscular appearance and symmetry. The purpose of this retrospective case study was to describe changes in dietary intake, body mass/composition, and the menstrual cycle during the 20-week competition preparation (PREP) and 20-week post competition recovery (REC) periods of a drug-free amateur female figure competitor (age = 26–27, BMI = 19.5 kg/m2). Dietary intake (via weighed food records) and body mass were assessed daily and averaged weekly. Body composition was estimated via Dual-energy X-ray absorptiometry (DXA) and 7-site skinfold measurements. Energy intake, body mass and composition, and energy availability decreased during the 20-week PREP period (changes of ~298 kcals, 5.1 kg, 6.5% body fat, and 5.4 kcal/kg fat free mass, respectively) and returned to baseline values by end of the 20-week REC period. Menstrual cycle irregularity was reported within the first month of PREP and the last menstruation was reported at week 11 of PREP. Given the potentially adverse health outcomes associated with caloric restriction, future, prospective cohort studies on the physiological response to PREP and REC are warranted in drug-free, female physique competitors.
A Review of Temperature, pH, and Other Factors that Influence the Survival of Salmonella in Mayonnaise and Other Raw Egg Products
Authors: Keerthirathne Thilini , Ross Kirstin , Fallowfield Howard , Whiley Harriet
Published: November 2016

Salmonellosis is one of the main causes of foodborne illnesses worldwide, with outbreaks predominately linked to contamination of eggs and raw egg products, such as mayonnaise. This review explores previous studies that have investigated Salmonella control mechanisms utilized in the production of raw egg mayonnaise and other food products. Apart from the use of pasteurized eggs, the main control mechanism identified is the pH of the raw egg products, which plays an important role in the consistency and stability while affecting the survival of Salmonella spp. However, currently there is no consensus regarding the critical pH limit for the control of Salmonella. The effectiveness of pH as a control mechanism is influenced by the type of acid used, with the effectiveness of lemon juice compared with vinegar highly debated. Additionally, Salmonella susceptibility to pH stresses may also be influenced by storage temperature (in some studies refrigeration temperatures protected Salmonella spp. from acidulants) and is further complicated by the development of Salmonella cross-tolerance-induced responses, pH homeostasis achieved by the cellular antiport and symport systems, and acid tolerance response (ATR). These mechanisms all provide Salmonella with an added advantage to ensure survival under various pH conditions. Other confounding factors include the fat content, and the addition of NaCl, garlic and plant essential oils (PEOs) from mint, cinnamon, cardamom and clove.
30ièmes Journées Franco-Belges de Pharmacochimie
Authors: Aci-Sèche Samia , Buron Frédéric , Plé Karen , Robin Laurent , Suzenet Franck , Routier Sylvain
Published: November 2016

The “Journées Franco-Belges de Pharmacochimie” is a recognized annual meeting in organic and medicinal chemistry known for the quality of scientific exchange and conviviality. Young researchers were encouraged to present their work and share ideas with senior scientists. Abstracts of plenary lectures, oral communications, and posters presented during the meeting are collected in this report.
Single Microwave Photon Detection with a Trapped Electron
Authors: Cridland April , Lacy John , Pinder Jonathan , Verdú José
Published: November 2016

We investigate theoretically the use of an electron in a Penning trap as a detector of single microwave photons. At the University of Sussex we are developing a chip Penning trap technology, designed to be integrated within quantum circuits. Microwave photons are guided into the trap and interact with the electron’s quantum cyclotron motion. This is an electric dipole transition, where the near field of the microwave radiation induces quantum jumps of the cyclotron harmonic oscillator. The quantum jumps can be monitored using the continuous Stern-Gerlach effect, providing the quantum non demolition signal of the microwave quanta. We calculate the quantum efficiency of photon detection and discuss the main features and technical challenges for the trapped electron as a quantum microwave sensor.
Olefin–Styrene Copolymers
Authors: Galdi Nunzia , Buonerba Antonio , Oliva Leone
Published: November 2016

In this review are reported some of the most relevant achievements in the chemistry of the ethylene–styrene copolymerization and in the characterization of the copolymer materials. Focus is put on the relationship between the structure of the catalyst and that of the obtained copolymer. On the other hand, the wide variety of copolymer architecture is related to the properties of the material and to the potential utility.
Enhanced Transdermal Permeability via Constructing the Porous Structure of Poloxamer-Based Hydrogel
Authors: Wang Wen-Yi , Hui Patrick , Wat Elaine , Ng Frency , Kan Chi-Wai , Lau Clara , Leung Ping-Chung
Published: November 2016

A major concern for transdermal drug delivery systems is the low bioavailability of targeted drugs primarily caused by the skin’s barrier function. The resistance to the carrier matrix for the diffusion and transport of drugs, however, is routinely ignored. This study reports a promising and attractive approach to reducing the resistance to drug transport in the carrier matrix, to enhance drug permeability and bioavailability via enhanced concentration-gradient of the driving force for transdermal purposes. This approach simply optimizes and reconstructs the porous channel structure of the carrier matrix, namely, poloxamer 407 (P407)-based hydrogel matrix blended with carboxymethyl cellulose sodium (CMCs). Addition of CMCs was found to distinctly improve the porous structure of the P407 matrix. The pore size approximated to normal distribution as CMCs were added and the fraction of pore number was increased by over tenfold. Transdermal studies showed that P407/CMCs saw a significant increase in drug permeability across the skin. This suggests that P407/CMC with improved porous structure exhibits a feasible and promising way for the development of transdermal therapy with high permeability and bioavailability, thereby avoiding or reducing use of any chemical enhancers.
Combined Estimation and Optimal Control of Batch Membrane Processes
Authors: Jelemenský Martin , Pakšiová Daniela , Paulen Radoslav , Latifi Abderrazak , Fikar Miroslav
Published: November 2016

In this paper, we deal with the model-based time-optimal operation of a batch diafiltration process in the presence of membrane fouling. Membrane fouling poses one of the major problems in the field of membrane processes. We model the fouling behavior and estimate its parameters using various methods. Least-squares, least-squares with a moving horizon, recursive least-squares methods and the extended Kalman filter are applied and discussed for the estimation of the fouling behavior on-line during the process run. Model-based optimal non-linear control coupled with parameter estimation is applied in a simulation case study to show the benefits of the proposed approach.
Correction: Singh, A., et al. Remote Sensing of Storage Fluctuations of Poorly Gauged Reservoirs and State Space Model (SSM)-Based Estimation. Remote Sens. 2015, 7, 17113–17134
Authors: Singh Alka , Kumar Ujjwal , Seitz Florian
Published: November 2016

The authors wish to make the following corrections to their paper [1].[...]
Estimating and Up-Scaling Fuel Moisture and Leaf Dry Matter Content of a Temperate Humid Forest Using Multi Resolution Remote Sensing Data
Authors: Adab Hamed , Devi Kanniah Kasturi , Beringer Jason
Published: November 2016

Vegetation moisture and dry matter content are important indicators in predicting the behavior of fire and it is widely used in fire spread models. In this study, leaf fuel moisture content such as Live Fuel Moisture Content (LFMC), Leaf Relative Water Content (RWC), Dead Fuel Moisture Content (DFMC), and Leaf Dry Matter Content (LDMC) (hereinafter known as moisture content indices (MCI)) were calculated in the field for different forest species at 32 sites in a temperate humid forest (Zaringol forest) located in northeastern Iran. These data and several relevant vegetation-biophysical indices and atmospheric variables calculated using Landsat 7 Enhanced Thematic Mapper Plus (ETM+) data with moderate spatial resolution (30 m) were used to estimate MCI of the Zaringol forest using Artificial Neural Network (ANN) and Multiple Linear Regression (MLR) methods. The prediction of MCI using ANN showed that ETM+ predicted MCI slightly better (Mean Absolute Percentage Error (MAPE) of 6%–12%)) than MLR (MAPE between 8% and 17%). Once satisfactory results in estimating MCI were obtained by using ANN from ETM+ data, these data were then upscaled to estimate MCI using MODIS data for daily monitoring of leaf water and leaf dry matter content at 500 m spatial resolution. For MODIS derived LFMC, LDMC, RWC, and DLMC, the ANN produced a MAPE between 11% and 29% for the indices compared to MLR which produced an MAPE of 14%–33%. In conclusion, we suggest that upscaling is necessary for solving the scale discrepancy problems between the indicators and low spatial resolution MODIS data. The scaling up of MCI could be used for pre-fire alert system and thereby can detect fire prone areas in near real time for fire-fighting operations.
A Node Localization Algorithm Based on Multi-Granularity Regional Division and the Lagrange Multiplier Method in Wireless Sensor Networks
Authors: Shang Fengjun , Jiang Yi , Xiong Anping , Su Wen , He Li
Published: November 2016

With the integrated development of the Internet, wireless sensor technology, cloud computing, and mobile Internet, there has been a lot of attention given to research about and applications of the Internet of Things. A Wireless Sensor Network (WSN) is one of the important information technologies in the Internet of Things; it integrates multi-technology to detect and gather information in a network environment by mutual cooperation, using a variety of methods to process and analyze data, implement awareness, and perform tests. This paper mainly researches the localization algorithm of sensor nodes in a wireless sensor network. Firstly, a multi-granularity region partition is proposed to divide the location region. In the range-based method, the RSSI (Received Signal Strength indicator, RSSI) is used to estimate distance. The optimal RSSI value is computed by the Gaussian fitting method. Furthermore, a Voronoi diagram is characterized by the use of dividing region. Rach anchor node is regarded as the center of each region; the whole position region is divided into several regions and the sub-region of neighboring nodes is combined into triangles while the unknown node is locked in the ultimate area. Secondly, the multi-granularity regional division and Lagrange multiplier method are used to calculate the final coordinates. Because nodes are influenced by many factors in the practical application, two kinds of positioning methods are designed. When the unknown node is inside positioning unit, we use the method of vector similarity. Moreover, we use the centroid algorithm to calculate the ultimate coordinates of unknown node. When the unknown node is outside positioning unit, we establish a Lagrange equation containing the constraint condition to calculate the first coordinates. Furthermore, we use the Taylor expansion formula to correct the coordinates of the unknown node. In addition, this localization method has been validated by establishing the real environment.
Sensor for In-Motion Continuous 3D Shape Measurement Based on Dual Line-Scan Cameras
Authors: Sun Bo , Zhu Jigui , Yang Linghui , Yang Shourui , Guo Yin
Published: November 2016

The acquisition of three-dimensional surface data plays an increasingly important role in the industrial sector. Numerous 3D shape measurement techniques have been developed. However, there are still limitations and challenges in fast measurement of large-scale objects or high-speed moving objects. The innovative line scan technology opens up new potentialities owing to the ultra-high resolution and line rate. To this end, a sensor for in-motion continuous 3D shape measurement based on dual line-scan cameras is presented. In this paper, the principle and structure of the sensor are investigated. The image matching strategy is addressed and the matching error is analyzed. The sensor has been verified by experiments and high-quality results are obtained.
Smart Toys Designed for Detecting Developmental Delays
Authors: Rivera Diego , García Antonio , Alarcos Bernardo , Velasco Juan , Ortega José , Martínez-Yelmo Isaías
Published: November 2016

In this paper, we describe the design considerations and implementation of a smart toy system, a technology for supporting the automatic recording and analysis for detecting developmental delays recognition when children play using the smart toy. To achieve this goal, we take advantage of the current commercial sensor features (reliability, low consumption, easy integration, etc.) to develop a series of sensor-based low-cost devices. Specifically, our prototype system consists of a tower of cubes augmented with wireless sensing capabilities and a mobile computing platform that collect the information sent from the cubes allowing the later analysis by childhood development professionals in order to verify a normal behaviour or to detect a potential disorder. This paper presents the requirements of the toy and discusses our choices in toy design, technology used, selected sensors, process to gather data from the sensors and generate information that will help in the decision-making and communication of the information to the collector system. In addition, we also describe the play activities the system supports.
Indigenous Research and Romantic Nationalism
Authors: Atkinson Paul , Ryen Anne
Published: November 2016

In recent years, “indigenous research” and “indigenous methods” have become prominent themes in the general field of qualitative methodology. These ideas and their implications raise serious questions for the wider conduct of social research. We will outline some of those ideas, subjecting them to scrutiny, and ultimately using them to question the rise of Romanticism in contemporary social methodology. We develop these ideas to question the contemporary emphasis on the personal and the experiential in current methodological commentary.
Valuing Interest Rate Swap Contracts in Uncertain Financial Market
Authors: Xiao Chen , Zhang Yi , Fu Zongfei
Published: November 2016

Swap is a financial contract between two counterparties who agree to exchange one cash flow stream for another, according to some predetermined rules. When the cash flows are fixed rate interest and floating rate interest, the swap is called an interest rate swap. This paper investigates two valuation models of the interest rate swap contracts in the uncertain financial market. The new models are based on belief degrees, and require relatively less historical data compared to the traditional probability models. The first valuation model is designed for a mean-reversion term structure, while the second is designed for a term structure with hump effect. Explicit solutions are developed by using the Yao–Chen formula. Moreover, a numerical method is designed to calculate the value of the interest rate swap alternatively. Finally, two examples are given to show their applications and comparisons.
The Production of Food and Fiber: An Adaptation of CoP Features for Sustainable Water Use in Agribusiness
Authors: Harris Keith , James Harvey
Published: November 2016

Fresh water and arable land are essential for agricultural production and food processing. However, managing conflicting demands over water and land can be challenging for business leaders, environmentalists and other stakeholders. This paper characterizes these challenges as wicked problems. Wicked problems are ill-formed, fuzzy, and messy, because they involve many clients and decisions makers with conflicting values. They are also not solvable, but rather must be managed. How can agribusiness leaders effectively manage wicked problems, especially if they have little practice in doing so? This paper argues that a Community of Practice (CoP) and its tripartite elements of domain, community and practice can be effective in helping businesses manage wicked problems by focusing on the positive links between environmental stewardship and economic performance. Empirically, the paper examines three agribusinesses to assess the extent in which CoP is used as a strategy for sustainable water management.