bluuebunny/crossref_metadata_2025 huggingface dataset:
Crowdfunding to Compensate for Financial Burdens of Patients with Systemic Sclerosis
Authors: Okoli Theodore , Kassamali Bina , Lim Subin , Mir Raza H. , Young Katherine , Haseeb Sarah B. , Yang Kevin , Maher Jacqueline , Mazori Daniel R. , LaChance Avery H.
Published: March 2024

Systemic sclerosis (SSc) is a rare autoimmune disease associated with significant morbidity and mortality, as well as high financial burdens. This study examined the use of the crowdfunding platform GoFundMe as a means to support SSc-related medical care. We found that a subset of patients with systemic sclerosis turn to the crowdfunding platform GoFundMe in an attempt to cover out of pocket expenses related to their disease. However, these campaigns are met with limited success. Altogether, our study demonstrates the significant medical and financial burden faced by individuals with SSc.
Prevalence of Asthma among Children and Adolescents in WHO's Eastern Mediterranean Region: A Meta-Analysis of Over 0.5 Million Participants
Authors: Taherian Mohammad Reza , Fatemian Farbod , Halimi Aram , Soleimani Yaser , Jorjani Goljamal , Nozari Parisa , Mosavi-Jarrahi Alireza , Nazari Seyed Saeed Hashemi , Al-Yateem Nabeel , Al-Marzouqi Amina , Humid Aysha , Rahman Syed Azizur
Published: March 2024

Objective: This study aims to evaluate the epidemiology of asthma among children and adolescents in the Eastern Mediterranean Region (EMRO).
Methods: Exhaustive searches were conducted across databases, including PubMed, Scopus, Web of Knowledge Core Collection, Embase, and Google Scholar. The selection criteria included studies in English and Persian languages reporting asthma prevalence in individuals aged 0 to 19 years, using validated questionnaires. Data were extracted and synthesized using the DerSimonian and Laird random effects model.
Results: The overall prevalence of asthma in Eastern Mediterranean Regional Office (EMRO) countries, among the 514,468 children and adolescents included in this meta-analysis, was 10.61%, synthesized from 95 studies. Among the countries studied, Qatar exhibited the highest prevalence at 16.69%, followed by Saudi Arabia at 16.57%, Iraq at 16.22%, Oman at 15.20%, and Afghanistan at 14.90%. Adolescents showed a slightly higher prevalence of asthma at 10.10% compared to children at 9.70%. Boys exhibited a higher prevalence at 11.48% compared to girls at 9.75%. Urban areas demonstrated a higher prevalence at 11.27% compared to rural areas at 8.29%.
Conclusion: Efforts to reduce asthma prevalence in Arab countries and address underdiagnosis in African nations within the EMRO are crucial. Targeted interventions should focus on addressing environmental triggers and improving access to healthcare. Enhanced diagnostic capabilities and healthcare infrastructure are necessary in African countries. Collaborative action is essential to alleviate the asthma burden and promote respiratory health across the EMRO region.
Simulation of Sympathetic Cooling of Helium-like 9 Be 2+
Authors: Zhu Kai , Song Hongfang
Published: March 2024

The helium and helium-like atomic systems are of significant interest in the study of few-body systems due to their simple structures. Nevertheless, current spectroscopic assessments of He-like ions, such as Li+ and Be2+, encounter constraints in precision owing to the formidable Doppler effect inherent in ion beam experiments. Addressing this challenge, we propose a methodology of employing ion trap confinement and sympathetic cooling techniques to mitigate the impact of the Doppler effect on 9Be2+ ions. Through molecular dynamics simulations, we investigated the influence of different ion systems on the temperature and efficiency of sympathetic cooling for 9Be2+ ions. Our findings offer valuable insights for future endeavors aimed at conducting high-precision spectroscopic measurements involving trapped and cooled 9Be2+ ions or other He-like ions.
Spatiotemporal Patterns of Nitrogen Dioxide and Aerosol Optical Depth: A Case Study of Lahore Division
Authors: Zeeshan Muhammad , Shah Muhammad Abdullah
Published: March 2024

To understand the relationships among atmospheric trace gases, aerosol variability, and climate change, as well as to inform next-generation climate change and air quality models, a precise understanding of the intricate relationships between these variables and their sources is needed. Therefore, this study aimed to investigate the spatiotemporal variability of tropospheric nitrogen dioxide (NO2), aerosol optical depth (AOD), and particulate matter (PM2.5) retrieved from both satellite and ground-based data for the period of 2006 − 2023. Tropospheric NO2, obtained from the Ozone Monitoring Instrument (OMI)/Aura, has shown that the Lahore Division frequently has high annual mean NO2 concentrations (3.87 − 6.34 x1015 molecules.cm− 2). Seasonally, winters (4.86 − 8.09x1015 molecules.cm− 2) and autumns (4.18 − 6.85 x1015 molecules.cm− 2) are mainly affected by high NO2 levels during 2021 − 2023 due to intense biomass and crop residue burning activities. Satellite AOD from data Moderate Resolution Imaging Spectroradiometer (MODIS)/Tera indicated that summers and autumns have greater AOD levels, with a mean value of 0.59 − 0.69. More variability in AOD was recorded just after the COVID − 19 lockdown. The NO2 − AOD correlation plots (maps) indicated a positive correlation coefficient R = 0.13 (0.02 to 0.19) in 2023, attributed to more NOx emissions. High concentrations of PM2.5 were recorded specifically in December and January, with the highest average AQI 374.96 µgm− 3, occurring on December 2022, which are the consequences of smog formation and other respiratory disorders during the winter season.
How is human well-being related to ecosystem service at town and village scales? A case study from the Yangtze River Delta, China
Authors: Gao Yanmin , Zhang Naijie , Ma Qun , Li Jingwei
Published: March 2024

Context: The relationships between ecosystem services (ES) and human well-being (HWB) have been found to be influenced by geographic locations and socioeconomic development, and vary from local to global scales. However, there is a lack of comparative analyses at fine administrative scales such as town and village scales.
Objective: This study took the core region of the Yangtze River Delta of China as the study area to examine the spatial characteristics of the value of ES and the subjective perception of HWB and compare their relationships at the town and village scales.
Methods: 9 ES and 11 HWB indicators were quantified using the ecosystem service equivalence factor method and the questionnaire survey, respectively. The ES-HWB relationships were then investigated using Spearman's correlation analysis.
Results: The value of ES per unit area in the study area in 2020 was about 15,202.90 USD/ha, nearly three times the average level in China, but the per capita value was relatively low, at 322.11 USD/person. The score of subjective perception of HWB was relatively high, especially for the dimensions of social relations, health, and safety. As spatial scales decreased from town to village and thematic scales increased from secondary to primary indicators, the strength of the ES-HWB correlations diminished and their direction changed as well. According to secondary indicators, most of the ES-HWB relationships were positive at the town scale but became negative or nonexistent at the village scale.
Conclusions: The ES-HWB relationships may vary unpredictably at local scales (e.g., counties). But “local scale” is not always local, because at the town and village scales the relationships can still vary. Thus, better understanding the relationships requires studies at multiple and broader scales and calls for the caution when using the aggregating indicators because they can also lead to different ES-HWB relationships.
Multifunctional lightweight autonomous vehicles: an agent-based study
Authors: Sanchez Naroa Coretti , Larson Kent
Published: March 2024

In mobility-on-demand services, the number of vehicles needed is often determined by peak demand during rush hours, leading to prolonged vehicle idle times during off-peak periods. This surplus capacity presents an opportunity for vehicles to perform additional tasks, potentially enhancing system efficiency and reducing the overall number of vehicles needed in cities. Leveraging agent-based modeling, we evaluate the effectiveness of vehicles catering to on-demand rides and food deliveries in two real-life scenarios: Cambridge, MA, USA, and San Sebastian, Gipuzkoa, Spain. The results show that multifunctional behavior can lead to reduced fleet sizes, with context-specific exceptions. Additionally, a strategic dispatching algorithm is introduced that demonstrates reductions in waiting times and overall distances traveled. This research contributes to the understanding of the performance of multifunctional fleets in diverse urban contexts, informing the development of sustainable and resource-efficient mobility systems.
Safety of pembrolizumab with concurrent radiotherapy in early stage breast cancer: preliminary prospective real-world evidence
Authors: Colciago Riccardo Ray , Presti Daniele , Giandini Carlotta , Rocca Eliana La , Carnevale Maria Grazia , Cavallo Anna , Pignoli Emanuele , Lobefaro Riccardo , Cosimo Serena Di , Listorti Chiara , Lozza Laura , Filippi Andrea Riccardo , De Santis Maria Carmen
Published: March 2024

INTRODUCTION Data on the feasibility and potential synergy of concomitant immunotherapy with radiation therapy (RT) is still scarce for early breast cancer (BC). We aimed to assess the safety profile of adjuvant pembrolizumab with concomitant radiotherapy (RT) in breast cancer patients.
MATERIAL AND METHODS: We prospectively collected data from ten patients with triple-negative breast cancer treated with neoadjuvant chemotherapy with pembrolizumab (as per Keynote-522 criteria) followed by surgery and at least 1 cycle of adjuvant pembrolizumab with concomitant RT. A total dose of 40.05 Gy delivered in 15 fractions was prescribed to the breast or chest wall, with regional nodes and tumor bed boost administered as clinically indicated. The study endpoint was to assess acute toxicity according to the Radiation Therapy Oncology Group scale, and to report the rate of discontinuation of RT and/or pembrolizumab.
RESULTS A median of 8 (range 4 – 9) cycles of neoadjuvant Pembrolizumab were prescribed. Before RT, patients received a median of 3 (range 2 – 4) cycles of adjuvant Pembrolizumab. Severe acute toxicity occurred in 2 patients. Specifically, G4 myositis led to permanent discontinuation of adjuvant pembrolizumab in one case, whereas G3 electrolyte imbalance caused definitive RT interruption and temporary discontinuation of adjuvant pembrolizumab in the second case. Among the remaining 8 patients, only 2 patients experienced G2 skin erythema with no treatment discontinuation.
CONCLUSIONS The combination of adjuvant pembrolizumab with concurrent radiotherapy proved feasible in the real world, as toxicity was minimal and consistent with existing literature.
Comparison of whole body bone mineral density measurement between dual-energy X-ray absorptiometry and novel foot-to-foot bioelectrical impedance analyzer
Authors: Chuang Chih-Lin , Lai Chung-Liang , Huang Ai-Chun , Su Bai-Hua , Chu Lee-Ping , Hsieh Kuen-Chang , Lu Hsueh-Kuan
Published: March 2024

Bone mineral density (BMD) is a crucial indicator of osteoporosis. Bioelectrical impedance analysis (BIA) introduces a new capability for assessing body composition, specifically BMD measurement. This study aimed to evaluate the accuracy of the novel BIA in conducting whole-body BMD tests in the general population of Taiwan. Altogether, 318 healthy adults in Taiwan (age, 37.67 ± 19.44 years; 145 male and 173 female patients) were included. Whole-body BMD was measured using foot-to-foot BIA-StarBIA201 (StarBIA Meditek Co. LTD, Taichung, Taiwan) and dual-energy X-ray absorptiometry (DXA) Lunar Prodigy (GE Medical Systems, Madison, WI, USA). Linear regression analysis, Pearson's correlation coefficient, Bland–Altman Plot, and paired t-test were used. Whole body BMD measured by BIA and DXA was 1.139 ± 0.124 g/cm2 and 1.202 ± 0.168 g/cm2, respectively. The regression equation was y = 1.057x + 0.063. The Pearson correlation coefficient, mean difference, and limits of agreement were r = 0.737, − 0.053 g/cm2, and − 0.290–0.165 g/cm2, respectively. Standing BIA was correlated with the DXA gold standard for estimating whole-body BMD in adults; however, their interchangeability remains limited. The convenient BIA method for measuring whole body BMD may be useful in the application of primary screening and future development of BMD assessment methods.
Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1
Authors: Blair Ian , Fan jingqi , Gillespie Kevin , Mesaros Clementina
Published: March 2024

Cisplatin and oxaliplatin cause the secretion of high mobility group box 1 (HMGB1) from cancer cells, which is necessary for initiation of immunogenic cell death (ICD). Calreticulin (CRT) translocation from the endoplasmic reticulum to the plasma membrane is also required; oxaliplatin induces this translocation but cisplatin does not. We have discovered that oxaliplatin causes the secretion of both HMGB1 and HMGB2 from the nucleus into the extracellular milieu. We previously showed that cisplatin mediated secretion of HMGB1 is controlled by the nuclear exporter XPO1 (chromosomal maintenance 1; CRM1). We now find that XPO1 regulates oxaliplatin mediated secretion of both HMGB1 and HMGB2. XPO1 inhibition causes nuclear accumulation of both proteins, inhibition of oxaliplatin-mediated ferroptosis of colon cancer cells, and inhibition of CRT translocation to the plasma membrane of lung and colon cancer cells. Incubation of cancer cells with cell targeted (CT)-HMGB2 confirmed that HMGB2 is responsible for translocation of CRT to the plasma membrane. CT-HMGB2 is three orders of magnitude more potent than oxaliplatin at inducing CRT translocation. Inhibition of HMGB1 and HMGB2 secretion and/or their activation of nuclear factor-kappa B (NF-κB) has potential utility for treating cardiovascular, and neurodegenerative diseases; whereas CT-HMGB2 could augment therapeutic approaches to cancer treatment.
SVHRSP alleviates age-related cognitive deficiency by reducing oxidative stress and neuroinflammation through Sirt 1 pathway
Authors: Wang Ying-zi , Wang Zhen-Hua , Guo Song-Yu , Li Qi-Fa , Kong Yue , Sui Ao-Ran , Ma Jian-Mei , Lu Li , Zhao Jie , Li Shao
Published: March 2024

Background
Our previous studies have shown that Scorpion venom heat-resistant synthesized peptide (SVHRSP) exhibits a significant extension in lifespan and improve in age-related physiological functions in worms. However, the mechanism underlying the potential anti-aging effects of SVHRSP in mammals remains elusive.
Methods
After conducting behaviour test, brain tissues were collected for morphological analysis, electrophysiology experiments, flow cytometry and protein or gene expression following SVHRSP treatment. H2O2-induced cell model was used to investigate the involvement of Sirt1 in the regulation of oxidative stress and inflammation mediated by SVHRSP.
Results
SVHRSP significantly ameliorated age-related cognitive decline, enhanced long-term potentiation, restored the synaptic loss, and upregulated the expression of synaptic proteins, thereby, indicating an improvement in synaptic plasticity. Moreover, SVHRSP demonstrated a decline in senescent markers, including SA-β-gal enzyme activity, p16, p12, Sirt1 and cell cycle arrest. The underlying mechanism involve an upregulation of antioxidant enzyme activity and a reduction in oxidative stress-induced damage. Furthermore, SVHRSP regulated the nucleoplasmic distribution of Nrf2 through sirt1-p53 pathway. Further research indicated that a reduction in the expression of pro-inflammatory factor in the brain after SVHRSP treatment. SVHRSP attenuated neuroinflammation by regulating the NF-κB nucleoplasmic distribution and inhibiting microglia and astrocytes activation through Sirt1-NF-κB pathway. Additionally, SVHRSP significantly augmented Nissl bodies count while suppressing the neuronal loss.
Conclusion
SVHRSP could remarkably improve cognitive deficiency by inhibiting oxidative stress and neuroinflammation through the activation of Sirt 1 pathway, thus representing an effective strategy to improve brain health.
From project to planning: development and effectiveness of the water-draw and utilization assessment policy in China
Authors: Cheng Zhe , Xu Yue , Li Yun , Zhu Yixin , Guo Li
Published: March 2024

The water-draw and utilization assessment (WDUA) policy is crucial for ensuring sustainable water development and good water governance in China. It consists of the WDUA in construction projects (WDUA-CP) and WDUA in urban planning (WDUA-UP). Based on a systematic review of the WDUA policy's development, this study evaluated the WDUA policy from the perspectives of policy text and implementation effectiveness using text-mining and statistical analysis methods. The results show that the WDUA policy is generally successful and has progressed across all regions in China. Despite existing regional gaps, effectiveness will continue to grow at the current situation of implementation. This study broadens the field of inquiry into China's water policy, enhances the method for assessing global water policy, and offers a fresh viewpoint for the international water community to understand China's integrated water resources management and water governance.
Biblioteca, universidad y sociedad
Authors: Meneses-Tello Felipe , Tanus Gabrielle Francinne de Souza Carvalho
Published: March 2024

Las bibliotecas universitarias contribuyen al desarrollo de las actividades de enseñanza, investigación y extensión de una universidad. Sin embargo, la dimensión social de la biblioteca universitaria no aparece claramente en la literatura, que se ha centrado en resaltar el aspecto administrativo y organizativo de sus procedimientos internos. Este artículo tiene como objetivo discutir la función social de las bibliotecas universitarias a partir de la noción social de servicios y los desafíos que deben afrontar en comunión con la sociedad y la universidad. Entre estos desafíos se destacan la relación entre las bibliotecas universitarias y la formación ciudadana, la diversidad cultural, los derechos humanos y el medio ambiente. A partir de una investigación bibliográfica exploratoria, nos hemos basado en autores que han estudiado las bibliotecas universitarias y temas conexos. Resaltamos que el compromiso de la biblioteca universitaria con lo social impacta a su comunidad interna (académica) y externa (sociedad), lo que requiere una gestión social vinculada a la promoción de principios y valores con el propósito de construir ciudadanía, valorar la diversidad cultural, respetar los derechos humanos y promover el cuidado del medio ambiente. Finalmente, pretendemos un giro social de la biblioteca universitaria, tanto práctico como teórico, a favor de una Bibliotecología social, superando la concepción tradicional, para así reforzar el carácter social y su compromiso con una sociedad más justa, equitativa y democrática.
The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer
Therapy
Authors: Bhattacharya Sankha , Beninger Paul
Published: March 2024

This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs)
as a promising avenue for cancer therapy within the embryonic landscape of nanotechnology. Nanoparticles,
pivotal in cancer treatment, are systematically examined for their diverse physicochemical structures, categorized
as organic (lipid-based, protein-based, and polymer-assisted) and inorganic (carbon-based and metal)
varieties. A significant focus is placed on CMNPs, which serve as an innovative drug delivery vehicle, overcoming
limitations associated with conventional nanoparticle therapies. This manuscript accurately explores
the advantages and challenges of various cell membranes, including those derived from cancer cells, red blood
cells, platelets, stem cells, and white blood cells. Importance is placed on their roles in enhancing drug delivery
precision, immune system circumvention, and targeted recognition. Detailed insights into the crafting of
CMNPs are provided, elucidating membrane extraction and fusion techniques, such as sonication, extrusion,
co-extrusion, and microfluidic electroporation. Maintaining membrane integrity during extraction and the benefits
of coating techniques in augmenting biocompatibility and targeted drug delivery are underscored. This
comprehensive resource consolidates the latest advancements in targeted drug delivery, positioning itself at
the forefront of nanotechnology and biomedicine research. Encapsulating various methodologies like membrane
extrusion, electrospray, and chemical conjugation, this manuscript showcases the expanding toolbox
available to researchers in this dynamic field. Focusing on the unique characteristics of CMNPs, this review explores
their multifaceted applications in biomedical research, particularly in tumour therapy. It provides an indepth
analysis of the biocompatibility of CMNPs, their stability, immune evasion capabilities, targeted drug delivery
precision, increased payload capacity, and retained biological functionality. The manuscript outlines current
applications and future prospects of CMNPs in targeted chemotherapy, photothermal and photodynamic
therapy, immunotherapy, gene therapy, and innovative therapeutic methods. It concludes by highlighting the
advantages of CMNPs in tumour therapy and their transformative potential in reshaping the landscape of cancer
treatment.
Volatile Oil of Magnolia biondii Pamp. for Transnasal Administration: Its
Preparation, Characterization, and Mechanism of Action in the
Treatment of Allergic Rhinitis
Authors: Guo Qiuting , Wang Xuan , Wang Yao , Zhou Peijie , Zhang Xiaofei
Published: March 2024

Background:

Allergic Rhinitis (AR) is a common chronic nasal condition usually
caused by allergens. The immune system overreacts when the body is exposed to allergens, releasing
a lot of tissue chemicals that cause congestion, more secretions, and an inflammatory reaction
in the nasal mucosa.

Method:

In clinical practice, it remains a significant public health issue. Modern pharmacological
studies have demonstrated that Magnolia Volatile Oil (MVO) has good anti-inflammatory, antibacterial,
immunomodulatory, and other pharmacological effects. Previous research and literature reports
have reported that MVO has good therapeutic effects on allergic rhinitis. However, due to
the poor water solubility of Magnolia, its bioavailability is low. The purpose of this present work
is to develop a new microemulsion formulation to improve the stability and bioavailability of
MVO.

Results:

The droplet size, PDI, and zeta potential of Magnolia volatile oil microemulsion (MVOME)
were characterized along with its physical characteristics, and these values were found to be
14.270.03 nm, 0.09410.31, and -0.35850.12 mV, respectively, demonstrating the successful formation
of microemulsion. In OVA-induced AR rats, MVO-ME dramatically reduced the serum levels
of TNF-α, IL-1β, and IL-6 inflammatory factors. In addition, MVO-ME significantly inhibited
the expression of protein levels of PPAR-γ and P65 in the nasal mucosa of AR rats. In this regard,
we hypothesized that MVO-ME may play a therapeutic role in AR by activating the PPAR signaling
pathway as well as inhibiting the activation of the NF/κB signaling pathway.

Conclusion:

MVO-ME has systematic advantages, such as high solubility, bioavailability, etc. It
is expected to be an efficient nano-drug delivery system for the clinical treatment of allergic rhinitis.
DNA Methylation-Based Diagnosis and Treatment of Breast Cancer
Authors: Peng Xintong , Zheng Jingfan , Liu Tianzi , Zhou Ziwen , Song Chen , Zhang Danyan , Zhang Xinlong , Huang Yan
Published: March 2024

DNA methylation is a key epigenetic modifier involved in tumor formation, invasion,
and metastasis. The development of breast cancer is a complex process, and many studies have
now confirmed the involvement of DNA methylation in breast cancer. Moreover, the number of
genes identified as aberrantly methylated in breast cancer is rapidly increasing, and the accumulation
of epigenetic alterations becomes a chronic factor in the development of breast cancer. The
combined effects of external environmental factors and the internal tumor microenvironment promote
epigenetic alterations that drive tumorigenesis. This article focuses on the relevance of DNA
methylation to breast cancer, describing the role of detecting DNA methylation in the early diagnosis,
prediction, progression, metastasis, treatment, and prognosis of breast cancer, as well as recent
advances. The reversibility of DNA methylation is utilized to target specific methylation aberrant
promoters as well as related enzymes, from early prevention to late targeted therapy, to understand
the journey of DNA methylation in breast cancer with a more comprehensive perspective.
Meanwhile, methylation inhibitors in combination with other therapies have a wide range of
prospects, providing hope to drug-resistant breast cancer patients.
Cholesterol Absorption Inhibition by Some Nutraceuticals
Authors: Kumar Shivendra , Saha Sunam , Pathak Devender , Singh Talever , Kumar Atul , Singh Kuldeep , Mishra Avinash Kumar , Singh Sakshi , Singh Shubham
Published: March 2024

:

Hyperlipidemia, characterized by elevated levels of lipids in the blood, represents a
major risk factor for cardiovascular diseases, a leading cause of morbidity and mortality worldwide.
Conventional pharmacological interventions have been effective in managing hyperlipidemia,
but concerns about side effects and long-term use have prompted interest in alternative
approaches, particularly the use of nutraceuticals. This comprehensive review aims to summarize
and critically evaluate the current body of knowledge surrounding the role of nutraceuticals
in the management of hyperlipidemia. We provide an overview of the different classes of
nutraceuticals, including plant sterols, omega-3 fatty acids, soluble fiber, antioxidants, and various
herbal extracts, which have been investigated for their lipid-lowering properties. The mechanisms
of action of these nutraceuticals are discussed, highlighting their ability to modulate lipid
metabolism, reduce oxidative stress, and promote cardiovascular health.

:

Furthermore, we review the results of clinical trials and epidemiological studies that have assessed
the efficacy of nutraceutical interventions in lowering cholesterol levels, improving lipid profiles,
and reducing the risk of cardiovascular events. In addition to their lipid-lowering effects, we examine
the safety profile, dosage recommendations, and potential interactions of nutraceuticals with
conventional lipid-lowering medications. We also address the importance of patient adherence to
dietary and lifestyle modifications in conjunction with nutraceutical supplementation. While
nutraceuticals offer a promising avenue for managing hyperlipidemia, we emphasize the need for
further research to establish evidence-based guidelines for their use in clinical practice. Challenges
related to standardization, quality control, and regulatory considerations are also discussed. In conclusion,
this comprehensive review provides valuable insights into the potential of nutraceuticals as
adjunctive or alternative therapies for managing hyperlipidemia. While further research is needed,
the accumulating evidence suggests that nutraceuticals can play a valuable role in promoting cardiovascular
health and reducing the burden of hyperlipidemia-related diseases.
Red de asistentes técnicos agropecuarios :linkata
Authors:   Corporación Colombiana de Investigación Agropecuaria, Mosquera (Colombia),   Instituto Colombiano Agropecuario, Bogotá (Colombia)
Published: March 2024

Las redes son definidas como "un conjunto de nodos interconectados''. En este sentido las redes sociales son estructuras conformadas por actores y sus relaciones. Los actores, denominados nodos, son los elementos fundamentales de las redes, conectados entre sí mediante vínculos, enlaces o interrelaciones que permitan optimizar el esfuerzo y los recursos de quienes hacen parte de la misma.
Machine Learning–Based Approach for Identifying Research Gaps: COVID-19 as a Case Study
Authors: Abd-alrazaq Alaa , Nashwan Abdulqadir J , Shah Zubair , Abujaber Ahmad , Alhuwail Dari , Schneider Jens , AlSaad Rawan , Ali Hazrat , Alomoush Waleed , Ahmed Arfan , Aziz Sarah
Published: March 2024

Background

Research gaps refer to unanswered questions in the existing body of knowledge, either due to a lack of studies or inconclusive results. Research gaps are essential starting points and motivation in scientific research. Traditional methods for identifying research gaps, such as literature reviews and expert opinions, can be time consuming, labor intensive, and prone to bias. They may also fall short when dealing with rapidly evolving or time-sensitive subjects. Thus, innovative scalable approaches are needed to identify research gaps, systematically assess the literature, and prioritize areas for further study in the topic of interest.

Objective

In this paper, we propose a machine learning–based approach for identifying research gaps through the analysis of scientific literature. We used the COVID-19 pandemic as a case study.

Methods

We conducted an analysis to identify research gaps in COVID-19 literature using the COVID-19 Open Research (CORD-19) data set, which comprises 1,121,433 papers related to the COVID-19 pandemic. Our approach is based on the BERTopic topic modeling technique, which leverages transformers and class-based term frequency-inverse document frequency to create dense clusters allowing for easily interpretable topics. Our BERTopic-based approach involves 3 stages: embedding documents, clustering documents (dimension reduction and clustering), and representing topics (generating candidates and maximizing candidate relevance).

Results

After applying the study selection criteria, we included 33,206 abstracts in the analysis of this study. The final list of research gaps identified 21 different areas, which were grouped into 6 principal topics. These topics were: “virus of COVID-19,” “risk factors of COVID-19,” “prevention of COVID-19,” “treatment of COVID-19,” “health care delivery during COVID-19,” “and impact of COVID-19.” The most prominent topic, observed in over half of the analyzed studies, was “the impact of COVID-19.”

Conclusions

The proposed machine learning–based approach has the potential to identify research gaps in scientific literature. This study is not intended to replace individual literature research within a selected topic. Instead, it can serve as a guide to formulate precise literature search queries in specific areas associated with research questions that previous publications have earmarked for future exploration. Future research should leverage an up-to-date list of studies that are retrieved from the most common databases in the target area. When feasible, full texts or, at minimum, discussion sections should be analyzed rather than limiting their analysis to abstracts. Furthermore, future studies could evaluate more efficient modeling algorithms, especially those combining topic modeling with statistical uncertainty quantification, such as conformal prediction.
Visualizing Empathy: Understanding Patient-Doctor Interactions through Eye-Tracking Technology (Preprint)
Authors: Park Yuyi , ­Kim Hyungsin , Kim Hakkyun
Published: March 2024

BACKGROUND

Communication between patients and doctors in healthcare settings is fundamental for positive patient health outcomes. Nonetheless, researchers have paid scant attention to the significance of clinical empathy as a practical skill in these interactions.

OBJECTIVE

This study aims to comprehend clinical empathy during doctor–patient encounters by examining doctors’ and patients’ verbal and nonverbal behaviors. Using eye-tracking techniques, we focus on the relationship between traditionally assessed clinical empathy and a doctor’s gaze behavior.

METHODS

We employed mixed methods to understand clinical encounters by a comparison of three quantitative measures—eye tracking data, K-JSE-HP scores, and CARE scores, and with qualitative interviews with patients regarding their encounters.

RESULTS

Perceived empathy from physicians was notably higher when doctors maintained eye contact during consultations, as indicated by gaze patterns focusing on patients’ faces. Furthermore, an analysis of Areas of Interest (AOI) revealed distinct patterns in interactions with new versus returning patients. Post-consultation interviews suggested that task- and social-oriented empathy are critical in aligning with patients’ expectations of empathetic communication.

CONCLUSIONS

This proof-of-concept study advocates for a multidimensional approach to clinical empathy, revealing that a combination of verbal and nonverbal behaviors significantly bolsters perceived empathy from healthcare providers. This evolved paradigm of empathy underscores profound consequences for the pedagogy of medical education and the caliber of healthcare delivery.
High Intensity Interval Training (HIIT) dalam Meningkatkan Daya Tahan dan Mencegah Cedera pada Pemain Bulu Tangkis
Authors: Setiawan Cahyo , Jannah Suci Muqodimatul , Kurniawan Muhammad Dwi , Nurhayati Shahad Erma
Published: March 2024

Latar   Belakang: High-Intensity Interval Training (HIIT) merupakan latihan terbaik untuk meningkatkan daya tahan tubuh dan mencegah cedera. Latihan tersebut adalah latihan kardiovaskular yang menggabungkan latihan intensitas tinggi dalam dosis tertentu. Selain melakukan gerakan raket yang kompleks, pemain bulutangkis membutuhkan koordinasi motorik yang tinggi, stamina kardiovaskular, kelincahan, kekuatan, kecepatan, dan ketepatan. Pemain bulutangkis juga rentan mengalami cedera.Tujuan: Penelitian ini bertujuan untuk mengetahui efektifitas pemberian High-Intensity Interval Training untuk meningkatkan daya tahan dan mencegah cedera pada pemain bulutangkis.Metode: Penelitian ini merupakan penelitian kuasi eksperimen dengan desain one group study. Terdapat 15 pemain bulutangkis berusia antara 18 hingga 25 tahun yang berpartisipasi dalam penelitian ini. Paired t-test dilakukan untuk mengevaluasi efek pelatihan dan dianalisis menggunakan SPSS.Hasil: Hasil penelitian ini menunjukkan adanya peningkatan yang signifikan (p<0,05) dalam daya tahan atletik setelah HIIT dengan peningkatan 2,8% dalam kinerja ketahanan mereka. Ada juga efek yang signifikan (p<0,005) dalam pencegahan risiko cedera dengan rata-rata sebesar 1,1%.Kesimpulan: Penelitian ini menunjukkan bahwa program Latihan HIIT dapat memberikan efek yang signifikan dalam meningkatkan komponen fisik, terutama daya tahan, dan mencegah cedera.
Transformasi Ketahanan Wilayah pada Era Digital: Peran Kepemimpinan Digital dalam Membangun Smart City di Kota Pariaman Sumatera Barat
Authors: Hanita Margaretha
Published: March 2024

ABSTRACT The digital revolution in public services is a response to the massive development of technology and information systems. The Government of Pariaman City has transformed into a smart city by developing various digital services. This research aims to analyze various digital services in Pariaman City to support the city's strategic leadership and digital leadership. The method used is phenomenology. Data used in this study are derived from literature reviews and observations on various developed applications. Data validation was carried out through triangulating observations, government documents and records, literature studies, member checking, and expert responses. The research results show that the Government of Pariaman City provides digital services in the form of applications/information systems and websites containing information and facilitating public access to public services. The utilization of digital services by the community eases the government's data collection process, including data related to population, economy, security, welfare, disasters, and civil servant performance. These data are used for the development planning of Pariaman City. In the context of regional resilience, Pariaman City can undergo rapid transformation through digitalization approaches. Therefore, the various digital services developed in Pariaman City greatly support the realization of regional resilience through digital leadership.
Film Dokumenter “Hula-Keta” Sebagai Media Penguatan Ketahanan Sosial-Budaya Di Kota Tidore Kepulauan
Authors: Wijaya Daya Negri
Published: March 2024

ABSTRAKTulisan ini berupaya membahas strategi pelestarian hula-keta (sagu panggang) di Tidore dengan menggunakan film dokumenter. Dengan menggunakan metode etnografi dan pendekatan kualitatif, penulis mengumpulkan berbagai data (tekstual dan audio-visual) dengan berbagai teknik meliputi wawancara dengan para informan kunci, observasi beberapa lokasi penting, dan dokumentasi (pengambilan gambar dan video) beberapa lokasi bersejarah. Kekayaan data memudahkan penulis untuk menyusun jalan cerita film dan menyajikannya dalam bentuk film dokumenter. Penulis secara kolaboratif menginisiasi pembuatan film dokumenter bertajuk “hula-keta: bukan Maluku tanpa Sagu” (2023).Film ini mengisahkan aspek kesejarahan, pengolahan, dan cara menikmati sagu panggang itu. Selain itu, berbagai isu terkait eksistensi dan upaya pewarisan hula-keta juga digambarkan. Film ini dapat dijadikan sebagai media penguatan ketahanan sosial-budaya di Tidore. Jejak rekam film ini tetap dapat dinikmati oleh generasi penerus. Mereka diharapkan dapat terinspirasi dan meneruskan estafet pewarisan kebudayaan di Tidore. Selain itu, penulis juga berharap bahwa film dokumenter dapat digunakan untuk memberikan berbagai pesan moral pada khalayak.Para pembuat film dokumenter atau jenis film lainnya jangan hanya tergiur pada keuntungan yang didapat dan jumlah penonton yang melihat. Sudah seharusnya mereka ikut berpartispasi dalam melestarikan kebudayaan daripada berfokus melakukan komodifikasi kebudayaan itu sendiri
Desarrollo de habilidades socioemocionales en educación media superior: un reporte de caso
Authors: Pontigo-Suárez Marian Elizabeth , López Toledo Gustavo , Sampieri-Cabrera Raúl
Published: March 2024

Las habilidades socioemocionales (HSE) son cruciales para ayudar a los individuos a comprender y regular sus emociones, fomentar la empatía, construir relaciones positivas y tomar decisiones responsables. Este documento expone la percepción de los profesores sobre un programa de formación docente en línea para el desarrollo de HSE en el aula. El diseño curricular se estructuró utilizando el modelo ADDIE (análisis, diseño, desarrollo, intervención y evaluación), y el paradigma de aprendizaje seguido es el constructivismo. La evaluación del curso se basó en comentarios cualitativos de los profesores participantes, quienes destacaron la utilidad del programa para mejorar sus actividades en el aula y señalaron desafíos relacionados con la carga de trabajo y la necesidad de una comunicación más clara de los objetivos del curso. A través de la construcción de un modelo conceptual se propone un ciclo continuo de mejora basado en la retroalimentación docente.
Educación flexible
Authors: Paulsen Morten Flate
Published: March 2024

En este video el Dr. Morten Flate Paulsen, quien ha dedicado su vida a la educación en línea, como se constata en sus cuatro libros de recurso abierto (https://www.nooa.no/my-online-education-world/), subraya la importancia de la flexibilidad en esta modalidad. Desde su propia escuela a nivel bachillerato en Noruega, observa las necesidades de sus estudiantes adultos tanto de carácter laboral como personal. Se trata de un llamado hacia la flexibilidad que permite iniciar el estudio en cualquier momento, avanzar al ritmo que cada quien requiera e incluso ofrece la posibilidad de definir cuándo completar las evaluaciones.
Factores de éxito de la Universidad Abierta de Indonesia. Entrevista con su Rector, Dr. Ojat Darojat
Authors: Vadillo Guadalupe
Published: March 2024

El Dr. Darojat presenta los tres mandatos que cumple la Universidad Abierta (Universitas Terbuka) de Indonesia con sus más de 500 mil estudiantes. Detalla los factores que considera relevantes durante el bachillerato para que los estudiantes de primer ingreso a educación superior cuenten con las habilidades requeridas. Además, señala que durante los estudios universitarios debe haber un equilibrio entre experiencia y conocimiento para lograr una mejor inserción de los egresados en la sociedad.
Diseño de tareas y materiales para recopilar un corpus de aprendices mexicanos de lengua inglesa
Authors: Flores Hernández Ana Abigahil , Moore Pauline
Published: March 2024

Este trabajo describe el proceso de diseño de una entrevista oral para recopilar datos de producción lingüística de aprendices de inglés como segunda lengua en universidades públicas mexicanas. El objetivo de la aplicación de este instrumento es crear un corpus de aprendices variado y representativo que sirva como base para investigaciones en adquisición de segunda lengua, así como para el diseño de materiales y estrategias de enseñanza acordes a las necesidades de los estudiantes mexicanos. Para ello se realizó una rigurosa selección de tareas y diseño de materiales con base en dos conceptos clave para el diseño de un corpus de aprendices: la autenticidad y la representatividad. El resultado es una entrevista de cuatro secciones alineadas a las actividades productivas orales monológicas de acuerdo con el Marco Común Europeo de Referencia para las lenguas (monólogo descriptivo, informativo y argumentativo). Las tareas además representan tres de los géneros textuales de acuerdo con el modelo de análisis multidimensional para textos orales: textos informativos, narrativos y de posicionamiento.
Dose Rate Calibration of β Radiation Source in Risø TL/OSL-DA-20 Reader Device
Authors: Avcı Hamide , Bulcar Kenan , Oğlakçı Mehmet , Atav Ülfet
Published: March 2024

This research is focused on determining the dose rate calibration of beta irradiation source in the Risø brand TL/OSL-DA-20 model thermoluminescence (TL) and optically stimulated luminescence (OSL) reader device manufactured by DTU Physics which is an integral component of the Technical University of Denmark (DTU). The beta radiation source of this device comprises a pellet-shaped Strontium ceramic made from the 90Sr/90Y radionuclide, with a half-life of approximately 29.1 years. This investigation provides a thorough examination of reproducing equivalent dose levels by comparing reproduced OSL signals with the OSL signals of calibration quartz crystals which were previously exposed to a 5 Gy beta radiation emission. Throughout this process, dose durations and equivalent dose levels were analysed on optically stimulated luminescence signals. The collected OSL data aims to ensure the precise calibration of the radioactive source, contributing to reliable results in dosimetric measurements. This calibrated device is utilized in the Luminescence Laboratory co-run by the Physics Department and Nuclear Materials Research and Application Center of Selçuk University. The determined dose rate of the beta radiation source is found as 0.065 Gy/second.
Neglected Aspects and Maladaptation to Rules in Low-Cost Housing, Malaysia: Social Practices of Commoning
Authors: Peng Au-Yong Cheong , Kok Wang Hong , Teck Ling Gabriel Hoh , Aun Law Kian , Abdullahi Bawa Chafe , Abd Aziz Wan Nor Azriyati Wan
Published: March 2024

The enactment, monitoring, and enforcement of rules play a crucial role in determining the success of self-organisation in common properties within high-rise housing developments. However, maladaptation to these rules can arise from diverse factors such as the parcel holders’ backgrounds, history, norms, and culture, leading to disrepair or the emergence of urban slums. This study examines two key issues: the influence of rules on the self-organisation of common properties, particularly in high-rise apartments, and the occurrence of maladaptation due to the forced relocation of urban squatters to new environments. Employing a mixed-method approach involving a questionnaire survey, interviews, and field observations, the findings underscore the significant impact of rules on self-organisation in high-rise housing. Furthermore, the forced relocation of urban squatters to unfamiliar environments comes at a heavy cost. The paper advocates heightened attention to soft human infrastructure, placemaking, and the introduction of commoning as a social practice to enhance adaptation to new living environments.
The Influence of Individual Characteristics on Poverty and The Role of Churches in Poverty Alleviation: A Case Study in Cianjur Regency, West Java
Authors: Viktor Yulianus , Kinseng Rilus A. , Muljono Pudji
Published: March 2024

A significant challenge for developing nations, including Indonesia, is the occurrence of poverty. An example of a poverty-stricken area based on the number of poor people is Cianjur Regency. Therefore, this study aimed to analyze the influence of religiosity, work ethics, age, education, occupation, and gender on the poverty level. It also intended to examine the perspectives of churches in Cianjur regarding poverty and its role in poverty mitigation. The methodology used was a mixed method with 100 respondents, and the sample size was determined proportionally and randomly from churches located in Cianjur Regency. The results from the BPS (Central Bureau of Statistics) showed that 18% of the 100 respondents lived in poverty, as opposed to the remaining 82%. In terms of work ethics, 71%, 29%, and 0% belonged to the high, moderate, and low categories, respectively. The independent variables that significantly affect the poverty level are religiosity, age, and occupation. The independent variables that were not significant were work ethics, education, and sex. This study also shows that the five churches had diverse perspectives on poverty. Some actively implemented programs are aimed at poverty reduction, while others lack specific initiatives to address poverty.
A practical approach for tectonic discrimination of basalts using geochemical data through machine learning
Authors: Gao Mengqi , Zhang Zhaochong , Ji Xiaohui , Li Hengxu , Cheng Zhiguo , Santosh M.
Published: March 2024

Identifying the tectonic setting of formation of rocks is an essential
component in the field of geosciences. The conventional approach is to
employ standard tectonic discrimination diagrams based on elemental
correlations and ratios, which sometimes are plagued with uncertainties
and limitations. The application of machine learning algorithms based on
big data can effectively overcome these problems. In this study, three
machine learning algorithms, namely Support Vector Machine, Random
Forest, and XGBoost, were employed to classify the various types of
basalts from diverse settings such as intraplate basalts, island arc
basalts, ocean island basalts, mid-ocean ridge basalts, back-arc basin
basalts, oceanic flood basalts, and continental flood basalts into seven
tectonic environments. For the altered basalts and fresh basalt, we use
22 relatively immobile elements (TiO2, P2O5, Nb, Ta, Zr, Hf, Y, La, Ce,
Pr, Nd, Sm, Eu, Gd, Ho, Er, Yb, Lu, Dy, Tb, Cr, Ni) and 35 major plus
trace elements to build discrimination models for seven types of
tectonic settings of basalt, respectively. The results indicate that
XGBoost demonstrates the best performance in discriminating basalts into
seven tectonic settings, achieving an accuracy of 85% and 89%
respectively. Compared to previous models, our new method presented in
this study is expected to have better practical applications.