bluuebunny/crossref_metadata_2025 huggingface dataset:
Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology
Authors: Gesenhues Jonas , Hein Marc , Ketelhut Maike , Habigt Moriz , Rüschen Daniel , Mechelinck Mare , Albin Thivaharan , Leonhardt Steffen , Schmitz-Rode Thomas , Rossaint Rolf , Autschbach Rüdiger , Abel Dirk
Published: January 2017

Computational models of biophysical systems generally constitute an essential component in the realization of smart biomedical technological applications. Typically, the development process of such models is characterized by a great extent of collaboration between different interdisciplinary parties. Furthermore, due to the fact that many underlying mechanisms and the necessary degree of abstraction of biophysical system models are unknown beforehand, the steps of the development process of the application are iteratively repeated when the model is refined. This paper presents some methods and tools to facilitate the development process. First, the principle of object-oriented (OO) modeling is presented and the advantages over classical signal-oriented modeling are emphasized. Second, our self-developed simulation tool ModeliChart is presented. ModeliChart was designed specifically for clinical users and allows independently performing
Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation
Authors: Brendle Christian , Mülders Thorsten , Kühn Jan , Janisch Thorsten , Kopp Rüdger , Rossaint Rolf , Stollenwerk Andre , Kowalewski Stefan , Misgeld Berno , Leonhardt Steffen , Walter Marian
Published: January 2017

A new concept is presented for cooperative automation of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) therapy for treatment of acute respiratory distress syndrome (ARDS). While mechanical ventilation is continuously optimized to promote lung protection, extracorporeal gas transfer rates are simultaneously adjusted to control oxygen supply and carbon dioxide removal using a robust patient-in-the-loop control system. In addition, the cooperative therapy management uses higher-level algorithms to adjust both therapeutic approaches. The controller synthesis is derived based on the introduced objectives, the experimental setup and the uncertain models. Finally, the autonomous ARDS therapy system capabilities are demonstrated and discussed based on
Influence of surface roughness of dental zirconia implants on their mechanical stability, cell behavior and osseointegration
Authors: Strickstrock Monika , Rothe Holger , Grohmann Steffi , Hildebrand Gerhard , Zylla Isabella M. , Liefeith Klaus
Published: January 2017

It is generally accepted that a micrometer scale roughness supports the osseointegration of titanium implants. While abrasive technologies can easily be employed to create a micro-topography on titanium surfaces, the preparation of rough ceramic surfaces is more challenging. Typically, abrasive treatments of yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) surfaces result in rather smooth topographies (R
Application of photocatalytic paint for destruction of benzo[a]pyrene. Impact of air humidity
Authors: Homa Piotr , Tryba Beata
Published: January 2017

Latex (LX) paint was tested for photocatalytic decomposition of benzo[a]pyrene (BaP) under different conditions of relative humidity (RH), temperature and irradiation. Porcelain trays coated with LX paint were loaded with BaP solution, which was dissolved in acetonitrile. Trays were placed inside the photoreactor and irradiated with UV or a fluorescent lamp. Different conditions of RH and temperature inside the photoreactor were used. BaP preliminarily adsorbed on LX paint surface was decomposed faster at higher temperature and lower RH. For example, at 42 °C and RH 20 % BaP decomposition rate reached 64 %. At same temperature and with RH of 80 % this rate decreased to only 42 %. It was also demonstrated that at high RH (80 %) and under UV irradiation water contact angle on the paint surface was decreasing at a lower rate than under RH of 20 %. It was also proven that BaP could be sufficiently decomposed under irradiation by fluorescent lamp (59 % in comparison to 64 % under same environmental conditions with use of UV light). However, its decomposition rate was approximately 5 times slower than under UV light
Investigation of antinociceptive activity of methanolic extract of Persicaria orientalis leaves in rodents
Authors: Ansari Prawej , Uddin Md. Josim , Akther Shafia , Azam Shofiul , Mahmud Md Kayes , Azad Sohel Bin , Ullah Ahsan , Hannan J.M.A.
Published: January 2017

Background:

This study aims to evaluate the scientific basis of traditional application of Persicaria orientalis for reducing pain and inflammation.

Methods:

An in vitro method was performed to investigate the presence of the anti-inflammatory activity of methanolic crude extract of P. orientalis. In addition, an in vivo study was conducted in which the hot-plate and tail immersion methods were applied to explore the acute effect of P. orientalis on analgesia. The potency to inhibit chronic inflammation in mice was justified by the carrageenan-induced paw edema and formalin-induced edema methods. For all in vivo testing in animal models (albino mice and rats), plant extract was given via the oral route at doses of 250 mg/kg and 500 mg/kg.

Results:

The methanolic extract of P. orientalis produced a significant (p<0.001) inhibition of analgesia with a prolongation of pain response time by 61.80% at 500 mg/kg. The extract also exhibited a potential anti-inflammatory (56.99%) effect, which was also statistically significant (p<0.001). The present study suggests that the methanolic extract of P. orientalis has potential anti-inflammatory as well as analgesic activity and this extract is effective in the treatment of both acute and chronic pain.

Conclusions:

Our current study revealed pharmacological properties of the methanolic extract of P. orientalis and also gave a solid scientific platform against its traditional use. The protecting ability of P. orientalis against inflammatory stimuli may be due to phenolic or flavonoid compounds which we have found through phytochemical analysis.
Fabricating waveguide Bragg gratings (WBGs) in bulk materials using ultrashort laser pulses
Authors: Ams Martin , Dekker Peter , Gross Simon , Withford Michael J.
Published: January 2017

Optical waveguide Bragg gratings (WBGs) can be created in transparent materials using femtosecond laser pulses. The technique is conducted without the need for lithography, ion-beam fabrication methods, or clean room facilities. This paper reviews the field of ultrafast laser-inscribed WBGs since its inception, with a particular focus on fabrication techniques, WBG characteristics, WBG types, and WBG applications.
Recent progress in asymmetric synthesis of aminophosphonic acids mediated by chiral sulfinyl auxiliary
Authors: Mikołajczyk Marian , Łyżwa Piotr
Published: January 2017

This account outlines the recent results on our strategy of the diastereoselective asymmetric synthesis of aminophosphonic acids (APs) using enantiomeric sulfinimines as chirality inducing reagents. Three important topics are discussed: (a) application of a double asymmetric induction in the synthesis of enantiomerically pure APs; (b) development of a general approach to the synthesis of γ-aminophosphonic acids (γ-APs) and (c) the use enantiomeric N-(p-tolylsulfinyl)cinnamaldimines in the synthesis of diverse α- and β-aminophosphonic acids (AP3, AP4) including the first synthesis of (R)-phosphoemeriamine.
Effect of the Pore Size Distribution on the Displacement Efficiency of Multiphase Flow in Porous Media
Authors: Yang Yongfei , Liu Pengfei , Zhang Wenjie , Liu Zhihui , Sun Hai , Zhang Lei , Zhao Jianlin , Song Wenhui , Liu Lei , An Senyou , Yao Jun
Published: January 2017

Due to the complexity of porous media, it is difficult to use traditional experimental methods to study the quantitative impact of the pore size distribution on multiphase flow. In this paper, the impact of two pore distribution function types for three-phase flow was quantitatively investigated based on a three-dimensional pore-scale network model. The results show that in the process of wetting phase displacing the non-wetting phase without wetting films or spreading layers, the displacement efficiency was enhanced with the increase of the two function distribution’s parameters, which are the power law exponent in the power law distribution and the average pore radius or standard deviation in the truncated normal distribution, and vice versa. Additionally, the formation of wetting film is better for the process of displacement.
Quasi-planar elemental clusters in pair interactions approximation
Authors: Chkhartishvili Levan
Published: January 2017

The pair-interactions approximation, when applied to describe elemental clusters, only takes into account bonding between neighboring atoms. According to this approach, isomers of wrapped forms of 2D clusters – nanotubular and fullerene-like structures – and truly 3D clusters, are generally expected to be more stable than their quasi-planar counterparts. This is because quasi-planar clusters contain more peripheral atoms with dangling bonds and, correspondingly, fewer atoms with saturated bonds. However, the differences in coordination numbers between central and peripheral atoms lead to the polarization of bonds. The related corrections to the molar binding energy can make small, quasi-planar clusters more stable than their 2D wrapped allotropes and 3D isomers. The present work provides a general theoretical frame for studying the relative stability of small elemental clusters within the pair interactions approximation.
Guarding the gate politically and politely: How accreditation teams do facework while gatekeeping
Authors: Ho Victor
Published: January 2017

Accreditation is a quality assurance mechanism which evaluates either the capability of an institution to offer an academic program or the quality of an academic program before its launch. Accredited institutions and programs are allowed to enroll students, both fee-paying and non-fee-paying. The outcome of an accreditation exercise will therefore have significant implications for an institution’s reputation and finance. Institutions are normally informed of the outcome through an accreditation report, a genre whose discourse is intrinsically interesting and important, and thus deserves fuller research attention, for two reasons: (1) the genre contains evaluations and comments which can be negative and face-threatening, and (2) the accreditation team, as we can safely assume, will do facework subsequent to the performance of face threats through the negative evaluations and comments. The present study seeks to gain a better understanding of the lexicogrammar of this genre in general, and the lexicogrammar used to textualize facework in particular by analyzing the discourse of 30 accreditation reports in an Australian context. This paper argues that the evaluative language used in this genre can serve to perform facework for both the institution being accredited and the accreditation team itself, and have important implications for both the workplace and classroom.
Comparison of high sensitive and conventional troponin assays in diagnosis of acute myocardial infarction
Authors: Işıksaçan Nilgün , Bıyık İsmail , Ertürk Mehmet , Koşer Murat , Karakurt Hüseyin , Özalp Begüm , Baycan Ömer Faruk , Yıldırım Mehmet Rıfat , Yazan Serkan , Aktürk İbrahim Faruk
Published: January 2017

Introduction

We aimed to compare the positive predictive values (PPV) and negative predictive values (NPV) of four cardiac troponin assays in the diagnosis of AMI in Turkish population.

Methods

This study is an observational comparative study, which is performed between 2012 and 2013 (527 patients). Troponin levels were measured with chemiluminescence Cobas troponin T assay, immunofluorescence Triage troponin I assay and immunochromatographic Toyo troponin I assay.

Results

Sensitivity and specificity of immunofluorometric assay (Radiometer) are 56.82% and 71.34%; immunochromatographic assay (Toyo) are 29.4% and 88.62%, immunofluorescence assay (Triage) are 47.13% and 76.12%, chemiluminescence assay (Roche) are 60.49 and 67.42%, respectively. PPV, NPV and positive likelihood ratios (LR+) of immunofluorometric assay (Radiometer) are 45.5%, 79.7% and 1.98, immunochromatographic assay (Toyo) are 51.5%, 75.4% and 2.58, immunofluorescence assay (Triage) are 46.5%, 76.6% and 1.97, chemiluminescence assay (Roche) are 45.8%, 78.9% and 1.86, respectively. In four assays, troponin levels were statistically significant higher in AMI positive group in comparison to negative group (p<0.001 for all).

Conclusion

There was no statistically significant difference between these troponin methods in comparisons of PPV and NPV in the diagnosis of AMI, but low sensitivity of Triage and Toyo assays should be considered.
Rogue Waves and Hybrid Solutions of the Boussinesq Equation
Authors: Rao Ji-Guang , Liu Yao-Bin , Qian Chao , He Jing-Song
Published: January 2017

The rational and semirational solutions in the Boussinesq equation are obtained by the Hirota bilinear method and long wave limit. It is shown that the rational solutions contain dark and bright rogue waves, and their typical dynamics are analysed and illustrated. The semirational solutions possess a range of hybrid solutions, and the hybrid of rogue wave and solitons are demonstrated in detail by the three-dimensional figures. Under certain parameter conditions, a new kind of semirational solutions consisted of rogue waves, breathers and solitons is discovered, which describes the dynamics of the rogue waves interacting with the breathers and solitons at the same time.
Thermal Conductance of a Surface Phonon-Polariton Crystal Made up of Polar Nanorods
Authors: Ordonez-Miranda Jose , Joulain Karl , Ezzahri Younes
Published: January 2017

We demonstrate that the energy transport of surface phonon-polaritons can be large enough to be observable in a crystal made up of a three-dimensional assembly of nanorods of silicon carbide. The ultralow phonon thermal conductivity of this nanostructure along with its high surface area-to-volume ratio allows the predominance of the polariton energy over that generated by phonons. The dispersion relation, propagation length, and thermal conductance of polaritons are numerically determined as functions of the radius and temperature of the nanorods. It is shown that the thermal conductance of a crystal with nanorods at 500 K and diameter (length) of 200 nm (20 μm) is 0.55 nW·K−1, which is comparable to the quantum of thermal conductance of polar nanowires.
Synthesis and Characterization of Zinc Oxide and Evaluation of its Catalytic Activities for Oxidative Degradation of Rhodamine B Dye in Aqueous Medium
Authors: Saeed Muhammad , Siddique Mohsin , Usman Muhammad , ul Haq Atta , Khan Samreen Gul , Raoof Hafiz Abdur
Published: January 2017

We herein report the synthesis of zinc oxide and evaluation of its catalytic performance for degradation of Rhodamine B dye in aqueous medium. Sodium hydroxide and zinc acetate dihydrate were used as precursor materials for synthesis of zinc oxide catalyst. X-ray difractometry, Fourier transform infer red spectroscopy, scanning electron microscopy, thermogravimetric and surface area analyses were used as characterization techniques. Catalytic performance of prepared zinc oxide was evaluated for degradation of Rhodamine B dye in aqueous medium. Catalytic degradation of dye was taking place according to Eley-Rideal mechanism which states that oxygen adsorbed at the surface of ZnO reacts with dye in fluid phase. During the reaction, reactive radicals are formed as a result of electron-hole pair formation between conduction and valence band of zinc oxide catalyst which degrade the dye into water and carbon dioxide.
Implementing Landmine Single-Leg Romanian Deadlift into an Athlete's Training Program
Authors: Weaver Ashley N. , Kerksick Chad M.
Published: January 2017

THE LANDMINE SINGLE-LEG ROMANIAN DEADLIFT (LANDMINE SL RDL) IS CLASSIFIED AS A UNILATERAL LOWER-BODY MOVEMENT THAT CAN BE USED TO BUILD STABILITY, STRENGTH, AND POWER THROUGHOUT AN ATHLETE'S POSTERIOR CHAIN AND CORE. THERE ARE CURRENTLY LITTLE TO NO ARTICLES PUBLISHED THAT DISCUSS THE USE OF LANDMINE EXERCISES. CONSEQUENTLY, THE PURPOSE OF THIS ARTICLE IS THREE-FOLD TO: (A) PROVIDE A DETAILED DISCUSSION ON HOW TO EXECUTE THE LANDMINE SL RDL PROPERLY, (B) DISCUSS THE BENEFITS OF THIS MOVEMENT, AND (C) DISCUSS HOW COACHES AND STRENGTH AND CONDITIONING PROFESSIONALS CAN INTEGRATE IT INTO PRACTICE.
Dynamic Encoding of Acoustic Features in Neural Responses to Continuous Speech
Authors: Khalighinejad Bahar , Cruzatto da Silva Guilherme , Mesgarani Nima
Published: January 2017

Humans are unique in their ability to communicate using spoken language. However, it remains unclear how the speech signal is transformed and represented in the brain at different stages of the auditory pathway. In this study, we characterized electroencephalography responses to continuous speech by obtaining the time-locked responses to phoneme instances (phoneme-related potential). We showed that responses to different phoneme categories are organized by phonetic features. We found that each instance of a phoneme in continuous speech produces multiple distinguishable neural responses occurring as early as 50 ms and as late as 400 ms after the phoneme onset. Comparing the patterns of phoneme similarity in the neural responses and the acoustic signals confirms a repetitive appearance of acoustic distinctions of phonemes in the neural data. Analysis of the phonetic and speaker information in neural activations revealed that different time intervals jointly encode the acoustic similarity of both phonetic and speaker categories. These findings provide evidence for a dynamic neural transformation of low-level speech features as they propagate along the auditory pathway, and form an empirical framework to study the representational changes in learning, attention, and speech disorders.

SIGNIFICANCE STATEMENTWe characterized the properties of evoked neural responses to phoneme instances in continuous speech. We show that each instance of a phoneme in continuous speech produces several observable neural responses at different times occurring as early as 50 ms and as late as 400 ms after the phoneme onset. Each temporal event explicitly encodes the acoustic similarity of phonemes, and linguistic and nonlinguistic information are best represented at different time intervals. Finally, we show a joint encoding of phonetic and speaker information, where the neural representation of speakers is dependent on phoneme category. These findings provide compelling new evidence for dynamic processing of speech sounds in the auditory pathway.
An ALS-Associated Mutant SOD1 Rapidly Suppresses KCNT1 (Slack) Na+-Activated K+Channels inAplysiaNeurons
Authors: Zhang Yalan , Ni Weiming , Horwich Arthur L. , Kaczmarek Leonard K.
Published: January 2017

Mutations that alter levels of Slack (KCNT1) Na+-activated K+current produce devastating effects on neuronal development and neuronal function. We now find that Slack currents are rapidly suppressed by oligomers of mutant human Cu/Zn superoxide dismutase 1 (SOD1), which are associated with motor neuron toxicity in an inherited form of amyotrophic lateral sclerosis (ALS). We recorded from bag cell neurons ofAplysia californica, a model system to study neuronal excitability. We found that injection of fluorescent wild-type SOD1 (wt SOD1YFP) or monomeric mutant G85R SOD1YFP had no effect on net ionic currents measured under voltage clamp. In contrast, outward potassium currents were significantly reduced by microinjection of mutant G85R SOD1YFP that had been preincubated at 37°C or of cross-linked dimers of G85R SOD1YFP. Reduction of potassium current was also seen with multimeric G85R SOD1YFP of ∼300 kDa or >300 kDa that had been cross-linked. In current clamp recordings, microinjection of cross-linked 300 kDa increased excitability by depolarizing the resting membrane potential, and decreasing the latency of action potentials triggered by depolarization. The effect of cross-linked 300 kDa on potassium current was reduced by removing Na+from the bath solution, or by knocking down levels of Slack using siRNA. It was also prevented by pharmacological inhibition of ASK1 (apoptosis signal-regulating kinase 1) or of c-Jun N-terminal kinase, but not by an inhibitor of p38 mitogen-activated protein kinase. These results suggest that soluble mutant SOD1 oligomers rapidly trigger a kinase pathway that regulates the activity of Na+-activated K+channels in neurons.

SIGNIFICANCE STATEMENTSlack Na+-activated K+channels (KCNT1, KNa1.1) regulate neuronal excitability but are also linked to cytoplasmic signaling pathways that control neuronal protein translation. Mutations that alter the amplitude of these currents have devastating effects on neuronal development and function. We find that injection of oligomers of mutant superoxide dismutase 1 (SOD1) into the cytoplasm of invertebrate neurons rapidly suppresses these Na+-activated K+currents and that this effect is mediated by a MAP kinase cascade, including ASK1 and c-Jun N-terminal kinase. Because amyotrophic lateral sclerosis is a fatal adult-onset neurodegenerative disease produced by mutations in SOD1 that cause the enzyme to form toxic oligomers, our findings suggest that suppression of Slack channels may be an early step in the progression of the disease.
Like Braiding Sweetgrass
Authors: Victor Janice M. , Goulet Linda M. , Schmidt Karen , Linds Warren , Episkenew Jo-Ann , Goulet Keith
Published: January 2017

The shifting environment of Indigenous community-based research demands reflexivity because the negotiation and maintenance of relationships are central (Findlay, Ray, & Basualdo, 2014). This paper expands on the importance of social relationships in the Nehinuw (Cree) worldview by reflecting on an ongoing research partnership among a team of Indigenous and Settler researchers from three universities and one Indigenous community agency. The Nehinuw relationships of weechihitowin (supporting and helping each other), weechiyauguneetowin (partnership, collaborative or shared action), otootemitowin (respectful openness and acceptance of others), and weechiseechigemitowin (alliances for common action) (L. Goulet & K. Goulet, 2014) form the theoretical framework for analyzing the challenges and successes that have sustained this collaboration for almost 10 years. This article will enhance understanding of Indigenous community-based research to promote an epistemological shift toward Indigenous modes of inquiry.
The role of glucocorticoids and corticotropin-releasing hormone regulation on anxiety symptoms and response to treatment
Authors: Raglan Greta B , Schmidt Louis A , Schulkin Jay
Published: January 2017

The stress response has been linked to the expression of anxiety and depression, but the mechanisms for these connections are under continued consideration. The activation and expression of glucocorticoids and CRH are variable and may hold important clues to individual experiences of mood disorders. This paper explores the interactions of glucocorticoids and CRH in the presentation of anxiety and depressive disorders in an effort to better describe their differing roles in each of these clinical presentations. In addition, it focuses on ways in which extra-hypothalamic glucocorticoids and CRH, often overlooked, may play important roles in the presentation of clinical disorders.
Liraglutide in polycystic ovary syndrome: a randomized trial, investigating effects on thrombogenic potential
Authors: Nylander Malin , Frøssing Signe , Kistorp Caroline , Faber Jens , Skouby Sven O
Published: January 2017

Polycystic ovary syndrome (PCOS) is associated with increased risk of venous thromboembolism (VTE) and cardiovascular disease (CVD) in later life. We aimed to study the effect of liraglutide intervention on markers of VTE and CVD risk, in PCOS. In a double-blind, placebo-controlled, randomized trial, 72 overweight and/or insulin-resistant women with PCOS were randomized, in a 2:1 ratio, to liraglutide or placebo 1.8 mg/day. Endpoints included between-group difference in change (baseline to follow-up) in plasminogen activator inhibitor-1 levels and in thrombin generation test parameters: endogenous thrombin potential, peak thrombin concentration, lag time and time to peak. Mean weight loss was 5.2 kg (95% CI 3.0–7.5 kg, P < 0.001) in the liraglutide group compared with placebo. We detected no effect on endogenous thrombin potential in either group. In the liraglutide group, peak thrombin concentration decreased by 16.71 nmol/L (95% CI 2.32–31.11, P < 0.05) and lag time and time to peak increased by 0.13 min (95% CI 0.01–0.25, P < 0.05) and 0.38 min (95% CI 0.09–0.68, P < 0.05), respectively, but there were no between-group differences. There was a trend toward 12% (95% CI 0–23, P = 0.05) decreased plasminogen activator inhibitor-1 in the liraglutide group, and there was a trend toward 16% (95% CI −4 to 32, P = 0.10) reduction, compared with placebo. In overweight women with PCOS, liraglutide intervention caused an approximate 5% weight loss. In addition, liraglutide affected thrombin generation, although not significantly differently from placebo. A concomitant trend toward improved fibrinolysis indicates a possible reduction of the baseline thrombogenic potential. The findings point toward beneficial effects of liraglutide on markers of VTE and CVD risk, which should be further pursued in larger studies.
In SilicoScrutiny of Genes Revealing Phylogenetic Congruence with Clinical Prevalence or Tropism Properties ofChlamydia trachomatisStrains
Authors: Ferreira Rita , Antelo Minia , Nunes Alexandra , Borges Vítor , Damião Vera , Borrego Maria José , Gomes João Paulo
Published: January 2017

Microbes possess a multiplicity of virulence factors that confer them the ability to specifically infect distinct biological niches. Contrary to what is known for other bacteria, for the obligate intracellular human pathogen Chlamydia trachomatis, the knowledge of the molecular basis underlying serovars’ tissue specificity is scarce. We examined all ~900 genes to evaluate the association between individual phylogenies and cell-appetence or ecological success of C. trachomatis strains. Only ~1% of the genes presented a tree topology showing the segregation of all three disease groups (ocular, urogenital, and lymphatic) into three well-supported clades. Approximately 28% of the genes, which include the majority of the genes encoding putative type III secretion system effectors and Inc proteins, present a phylogenetic tree where only lymphogranuloma venereum strains form a clade. Similarly, an exclusive phylogenetic segregation of the most prevalent genital serovars was observed for 61 proteins. Curiously, these serovars are phylogenetically cosegregated with the lymphogranuloma venereum serovars for ~20% of the genes. Some clade-specific pseudogenes were identified (novel findings include the conserved hypothetical protein CT037 and the predicted α-hemolysin CT473), suggesting their putative expendability for the infection of particular niches. Approximately 3.5% of the genes revealed a significant overrepresentation of nonsynonymous mutations, and the majority encode proteins that directly interact with the host. Overall, this in silico scrutiny of genes whose phylogeny is congruent with clinical prevalence or tissue specificity of C. trachomatis strains may constitute an important database of putative targets for future functional studies to evaluate their biological role in chlamydial infections.
Astigmatismo - Endoscopía
Authors: Voto Bernales Juan
Published: January 2017

Astigmatismo - Endoscopía.
Segunda prueba del Concurso de Anatomía Topográfica (Anatomía Clínica y Quirúrgica)
Authors: Quesada Fortunato
Published: January 2017

Segunda prueba del Concurso de Anatomía Topográfica (Anatomía Clínica y Quirúrgica).
Reflexiones sobre Educación Médica
Authors: Pou Orfila J.
Published: January 2017

Informe presentado a la Facultad de Medicina de Montevideo, a raíz de un viaje científico por los Estados Unidos y Europa (1923-1924)
Acerca de la exploración del sistema vago-simpático
Authors: O. Llerena Jorge
Published: January 2017

Las ciencias médicas, en su afán de renovación y progresos incesantes, nos depara, día a día, novedades sorprendentes. Lo que hasta ayer teníamos como verdad científica incorporada al acervo médico, se derrumba hoy al impulso de lozanas inducciones desprendidas de experimentaciones cada vez más precisamente condicionadas, que sobre la ruina de lo caduco levantan nuevos edificios, unas veces de efímera duración, y otras, moles tan sólidas, que desafiarán los tiempos. Pero, precisamente, en esta mutación, en este devenir está el secreto del progreso científico, y hay que respetarlo.
La Facultad de Medicina de Lima
Authors: Valdizán Hermilio
Published: January 2017

Segunda parte del libro del Doctor Hermilio Valdizán.
La verruga peruana y Daniel A. Carrión
Authors: Medina Casimiro
Published: January 2017

La verruga peruana y Daniel A. Carrión
Tratamiento de la parálisis general progresiva por el método de Wagner Von Jauregg (conclusión)
Authors: Pardo Figueroa Pedro
Published: January 2017

Creemos haber insistido suficientemente sobre los muy relativos discutibles peligros y contraindicaciones de la piroterapia, por lo que no insistiremos particularmente sobre esto. Es sabido que las lesiones cardiacas bien compensadas resisten bien el tratamiento malárico, siempre que se tengan bien precisadas la mayor o menor gravedad de las aortitis tan frecuentes en los paralíticos generales.
Contribución al estudio de la Bartonella Muris
Authors: Battistini T. , Weiss P.
Published: January 2017

1921 E. Mayer del Instituto Tropical de Hamburgo, estudiando la acción del "Bayer 0205" sobre ratas infectadas experimentalmente con tripanosoma Rhodesiense, observó la presencia de elementos en los glóbulos rojos, cuya morfología juzgó bastante semejante a la de la Bartonella bacilliformis agente etiológico de la verruga peruana.
Informe médico legal
Authors: Fernández Dávila Guillermo
Published: January 2017

Informe médico presentado por los forenses chilenos acerca de la autopsia practicada al carabinero José Zurita Gálvez.
La rebelión del libido sexual en la vejez
Authors: Valdizan Hermilio , Delgado Honorio
Published: January 2017

Conocidos los orígenes de la sexualidad y sus variaciones a lo largo de la jornada de la vida hemos pensado, el doctor Delgado y yo, en el vivo interés del conocimiento de la etapa evolutiva terminal de esa sexualidad. Y por ello, desde hace algunos años, venimos observando, con máxima atención, el libido senil de nuestros enfermos, tanto  en la práctica civil como en la nosocomial.
Hacia una concepción de la Verruga Peruana
Authors: Weiss Pedro
Published: January 2017

La Verruga Peruana es una enfermedad que compromete especialmente el aparato retículo- endotelial. Este comprommiso, que comienza al término de la fase hemática o Fiebre de Carrión, con la fijación del virus en los tejidos, alcanza el maximun de extensión durante el período que precede a la erupción, persistiendo durante el comienzo de esta, para quedar más tarde reducido a los botones verrucosos en los territorios donde estos se forman.
Fenómenos de reunión de los glóbulos rojos en rollos de monedas y en aglomerados irregulares. Velocidad de sedimentación de los glóbulos rojos. Grupos sanguíneos. Técnicas.
Authors: Ciotola Enrique
Published: January 2017

Las primeras observaciones de aglutinación de los glóbulos rojos producidos por el suero de animales pertenecientes a otra especie data de muchos años. La aglutinación de los glóbulos rojos de unos individuos, por los sueros de otros de la misma especie, es un hecho reciente. Shattock observó este fenómeno por primera vez con la sangre humana.
La acrodinia infantil
Authors: Krumdieck Carlos F.
Published: January 2017

Desde hace algunos años las revistas médicas se ocupan de una curiosa dolencia que ataca a los niños y que está caracterizada por trastornos nerviosos, sudores profusos y eritroedemas dolorosos de las extremidades. Los primeros casos fueron estudiados y presentados por Swift de Adelaida, al IX Congreso Médico Australiano, reunido en febrero de 1914, quien bajo el nombre de eritroedemia designó la enfermedad que nos ocupa.
La rehabilitación de la interpretación de los sueños
Authors: Delgado Honorio F.
Published: January 2017

Es tal vez imposible hallar en la historia de los pueblos uno en cuya mentalidad no haya tenido gran arraigo en concepto de que los sueños encarnan una significación de valor para el destino de las personas o la realización de los acontecimientos.
Contribución al estudio de la verruga peruana
Authors: Battistini Telémaco S.
Published: January 2017

Ocupémonos primero del aspecto morfológico de este organismo en preparaciones coloreadas. El Giemsa, el Wright y el azul de toluidina, lítico de Mackehenie son los únicos colorantes que permiten un exacto conocimiento estructural de la B.b. Frottis bien finos, fijados a temperatura de laboratorio, o con alcohol metílico, son coloreados con una solución de Giemsa por 10 o 15 minutos, lavados en un chorro fuerte de agua corriente que arrasa los precipitados que ocasionalemente se forman, sobre el magma amorfo del medio de cultivo, y se dejan secar al aire libre.
La enfermedad de los Andes (Síndromes eritrémicos)
Authors: Monge M. Carlos
Published: January 2017

Informe presentado a la Facultad de Medicina de Lima sobre estudios fisiológicos, fisiopatológicos y clínicos llevados a cabo en el hombre de las altiplanicies andinas, principalmente en Oroya (12,200 pies) y Morococha (14,800 pies). 1927.
La herencia como principal factor etiológico de la anormalidad mental y de ciertas degeneraciones y formas de criminalidad y su prevención eugénica
Authors: Fosalba Rafael G.
Published: January 2017

La herencia fisiológica, la transmisión de padres a hijos, a través de varias generaciones, de ciertos caracteres físicos y morales, ha sido reconocida desde los tiempos más remotos; pero, a medida que los nuevos métodos de investigación han permitido avanzar el estudio de la ciencia biológica, se han multiplicado las teorías para explicar en conjunto los fenómenos de la vida.
Contribución al estudio de la acrodinia
Authors: Krumdieck Carlos F.
Published: January 2017

El año 1927, tuvimos ocasión de señalar la existencia de la Acrodinia infantil en el Perú. El estudio de esa singular enfermedad, nos interesó vivamente, habiendo desde entonces, tratado de recolectar y estudiar el mayor número de observaciones que se publicaba en las revistas extranjeras, al mismo tiempo que procurado conseguir nuevas observaciones relativas a la enfermedad de Swift-Feer. Desgraciadamente, su rareza no nos ha permitido hacer estudios etiológicos, y la evolución generalmente benigna, tampoco ha dado márgen en los dos casos observados a hacer investigaciones anatomopatológicas.
Enfermedad de Carrión - Verruga Peruana - Fiebre de La Oroya
Authors: Rebagliati Raúl
Published: January 2017

Hasta el año 1870, una enfermedad endémica en ciertas localidades de los Andes peruanos intrigaba a los médicos, tanto peruanos como extranjeros. Su ertiología incierta; sus caracteres clínicos tan peculiares, muy especialmente la erupción de tumores rojos, sangrantes, consecutiva a un incosntante período febril irregular; su distribución geográfica, limira a ciertas zonas serranas perfectamente determinadas; las diversas leyendas populares relativas a su epidemiología; todo contribuía a considerar la Verruga peruana como enfermedad misteriosa, intangible.
Necrología
Authors: Rebagliati Raúl
Published: January 2017

Sepelio del Doctor Julián Arce. Sepelio del Doctor Belisario Sosa. Sepelio del Doctor Ramon E. Ribeyro. Sepelio del Doctor Estanislao Pardo Figueroa.
Política Sanitaria indiana y colonial en el Tahuantinsuyo
Authors: Monge M. Carlos
Published: January 2017

La existencia de poblaciones aclimatadas a la vida en las grandes alturas habitadas de América, desde una época prehistórica, entre 2000 y 6000 metros sobre el nivel del mar, plantea la necesidad de estudiar la Biología andina : hombre, plantas y animales. Las características del hombre de los Andes que corresponden determinados aspectos morfológicos y fisiológicos, han sido establecidas, por nosotros en la medida de nuestra capacidad, en la Escuela Médica de Lima.
Sobre algunas manifestaciones congestivas de orden cerebral en las eritremias de la altura
Authors: Monge M. Carlos
Published: January 2017

Desde nuestras primeras publicaciones llamamos la atención sobre ciertas perturbaciones de orden encefálico congestivo que sobrevenían por crisis en los inadaptados a la vida en las alturas y que, por el hecho, de ser muy frecuentes se encuentran aun en los casos moderados a condición de que un clínico sagaz ajuste bien el interrogatorio en la historia subjetiva del paciente.
La psiquiatría y la higiene mental en el Perú
Authors: Delgado Honorio
Published: January 2017

El estudio de los desórdenes mentales y el cuidado de quienes los padecen no tienen en nuestro país el desarrollo que corresponde a su importancia. No han faltado, empero, loables empeños y realizaciones apreciables, dignos de atención por su misma rareza. Todo lo hecho se localiza en Lima. De modo que tratar de la psiquiatría en Lima es tratar de la psiquiatría en el Perú. Cabe, sin embargo, separar y comparar la aportación de la Capital en lo que respecta al sujeto psiquiátrico, al enfermo. Según esto, en el presente artículo, será objeto de nuestro examen, con la debida brevedad : I, la historia de nuestra asistencia de alienados; II, el cultivo de la psiquiatría en el Perú; III, la población de enfermos de la mente procedentes de Lima y del resto del país; IV, la higiene mental en el Perú; y, V, la situación y los problemas que nos ofrece el presente en materia de asistencia, profilaxia y estudio de las perturbaciones psíquicas.
Estudios sobre las oxidaciones biológicas - La oxidación del ácido ascórbico (vitamina C) en los fluidos biológicos
Authors: Guzmán Barrón E. S. , Guzmán Barrón Alberto , Klemperer Friedrich
Published: January 2017

Los fluidos biológicos pueden ser divididos de acuerdo con su conducta hacia el ácido ascórbico en dos grupos : aquellos poseyendo un mecanismo inhibidor que protege al ácido ascórbico de la oxidación, y aquellos desprovistos de este mecanismo. Fluidos de origen animal y algunos de origen vegetal, (aquellos conteniendo cantidades dosables de ácido ascórbico) corresponden al primer grupo. El ácido ascórbico es protegido de la oxidación en dichos fluidos por la acción catalista del cobre. Los fluidos de origen vegetal (aquellos que contienen muy poco ácido ascórbico) corresponden al segundo grupo. El ácido ascórbico es oxidado en estos fluidos por una variedad de catalistas oxidantes, cobre y hemocromógenos, como lo prueba el efecto de los inhibidores. El efecto inhibitorio del glutaction es específico para la acción catalítica del ácido ascórbico por el hemocromógeno ferri-nicotina o por el jugo de zapallo amarillo.
Las doctrinas psicoanalíticas
Authors: De Allende Navarro Fernando
Published: January 2017

En los comienzos del siglo presente, un médico de Viena, Segismundo Freud, descubría un método original, llamado por sus alcances a provocar una verdadera revolución en nuestros conocimientos de psicología y se psicopatología y que, además, se enorgullecía de sanar radicalmente la histeria y las neurosis en general, afecciones que hasta entonces habían desafiado y burlado todos nuestros esfuerzos y procedimientos terapéuticos.
Contribución al estudio de la fisiología del hombre andino - Exploración funcional del sistema nervioso extracardiaco del andino
Authors: Aste Salazar J. Humberto
Published: January 2017

Iniciamos nuestros estudios en Lima (Abril 1934) con el reflejo óculo-cardíaco, continuándolos en Chiclayo y Lambayeque (Julio-Agosto 1934), donde además hicimos observaciones sobre la presión media dinámica y el reflejo solar.
Nuestras publicaciones médicas
Authors: Anales-de-la-Facultad-de-Medicina Redacción
Published: January 2017

Los médicos españoles y americanos que ejercieron la profesión en la Ciudad de los Reyes durante los primeros siglos del virreinato, no se curaron de la necesidad de un periódico, de un "papel" como se llamaba entonces, en cuyas páginas pudieran hallar benévola acogida investigaciones científicas o prolijas observaciones de la misma naturaleza. No faltaban argumentos que tratar, ya que los dichos médicos pudieron observar atentamente enfermedades hasta entonces no descritas por autor alguno y que se contaron entre los obstáculos que hubieron de vencer para llegar a la meta de sus aspiraciones los heroicos aventureros del fundador de Lima y conquistador del Perú; la verruga había saludado a los aventureros diezmándoles, afeándoles los rostros y amargándoles una angustiosa jornada; el tifus exantemático les había hecho conocer la magnitud de su poder devastador. Y, aparte de estos, la medicina de los indígenas, mitad charlatanismo y mitad herborísmo respetable, ofrecíales un vasto campo en el cual poder hurgar la verdad para hacerla conocer en beneficio de los que sufren. Desdichadamente, no era argumento que tratar el que hacía falta sino sujetos capaces de tratarlos : los médicos de aquella época fueron esencialmente prácticos, de mérito discutible en la generalidad de los casos y solo se contaron entre ellos unos pocos, que sobresalieron por sus calidades de carácter y por sus calidades de ingenio; pero aún estos, no manifestaron empeño alguno por legar a los postreros la prueba fehaciente de su laboriosidad provechosa en las páginas respetables de un libro bien intencionado.
Notas acerca de la Urea
Authors: Velásquez Manuel A.
Published: January 2017

La urea, peso molecular = 60, es considerada en justicia como el producto principal del metabolismo de las proteínas y como el más interesante de los constituyentes nitrogenados de la orina y como el más importante también, pues contiene un 45%de azoe y toma para ella el 85 a 90% del nitrógeno total de la orina. Contribuye a afirmar este concepto de la importancia de la urea, el hecho de que casi el 90% del nitrógeno introducido en la economía con los alimentos es eliminado por la orina bajo la forma de urea.
Algo sobre etiología y profilaxia de la locura a propósito del movimiento estadístico del "Hospicio de Insanos de Lima"
Authors: Delgado Honorio , Bambarén Carlos A.
Published: January 2017

Las informacíones estadísticas que resultan de la agrupación ordenada y precisa de los hechos, ofrecen al estudio de los elementos que intervienen en el complicado proceso de los fenómenos psiquiátricos. sólido asidero para escudriñar la trabazón que les liga a sus factores determinantes. La aplicación de tal método a la medicina mental no es, por lo demás, sino una manifestación parcial de su valer como instrumento de apreciación de la realidad dentro de los cánones científicos. Por eso créemos necesario y oportuno esbozar algunos comentarios a las cifras que nos suministra la comparación de los guarismos contenidos en las estadísticas de 1896 y 1916, para deducir las variantes numéricas de los alienados recluidos en el Hospicio de Insanos de Lima, coger su etiología según las condicíones actuales - que los factores etiológicos en otros períodos de nuestra historia han sido brillantemente tratados por nuestro maestro el Dr.HERMILIO VALDIZAN - coger su etiología según las condiciones actuales y reseñar la actitud profiláctica mas apropiada, en armonía con las enseñanzas de la higiene mental y las necesidades de nuestro porvenir psicosanitario.
Anuria completa postoperatoria por nefrectomía en un riñón único
Authors: Pazos Varela Ricardo
Published: January 2017

En el mes de julio de 1917, vi por primera vez a una enferma que se quejaba de dolor renal (puntos costo vertebral, sub-costal y supraintra-espinoso de PASTEAU). Este dolor coincidía con un movimiento febril intenso, y crisis semejantes se habían repetido en el curso de los cinco últimos años. De 16 años de edad, temperamento linfático, enmagrecida y pálida, se imponía como una tuberculosa.
Tumor del mediastino?
Authors: Odriozola Ernesto
Published: January 2017

Por una de aquellas coincidencias que con tanta frecuencia ocurren en el ejercicio de la clínica, nos toca hoy, al inaugurar nuestras labores del presente año, estudiar un enfermo exactamente comparable al que nos sirvió el año pasado, en idéntica oportunidad. Si alguno de los señores que hoy me escuchan, vió a ese enfermo, siguió su evolución y contempló las piezas anatómicas que de él se extrajeron, convendrá en esa casi perfecta similitud objetiva, que hace del presente caso un ejemplar clínico muy interesante, que despierta la mas viva curiosidad y cuyo preciso diagnóstico no es tan sencillo como podría creerse. Ya en la lección del año pasado, les decía que estos casos no son raros entre nosotros y el que habla ha tenido la ocasión de observar alrededor de veinte. La apariencia de ellos, es casi siempre mas o menos semejante, y su sentencia de muerte, con una sola excepción, es invariablemente inexorable, sin que valgan para remediarla ni la precocidad posible del diagnóstico, ni los maravillosos adelantos de la cirugía.
Métodos para investigar el funcionamiento renal
Authors: Velásquez Manuel A.
Published: January 2017

Siendo la orina, el líquido orgánico por el que se elimina la mayor parte de los productos del metabolismo, así como los medicamentos, una vez que han determinado su acción sobre el fisiologísmo perturbado, justo es que pueda apreciarse el valor funcional del riñón por las variaciones cualitativas y cuantitativas que ofrezca el producto de su funcionamiento.
El concepto nosográfico de la Medicina Tropical
Authors: Arce Julián
Published: January 2017

La creación de la cátedra de enfermedades tropicales, que tengo el honor de regentar interinamente, ha venido a satisfacer la necesidad imperiosa que había, de ampliar, en la extensión posible el estudio de esas morbosis, que tan de cerca nos interesan, aliviando a la vez, la pesada labor de la asignatura de nosografía médica, cuyas divisiones, sucesivas, impuestas por los adelantos de la ciencia moderna, aseguran la eficacia de la enseñanza y facilitan el aprendizaje de la medicina.
La Psicoterapia Extrapsiquiátrica
Authors: Valdizán Hermilio
Published: January 2017

Ustedes saben bien que la Psicoterapia ó Psicoterapéutica puede ser definida sintéticamente como "la cura de las enfermedades por medio del espíritu" ya que su acción benéfica es obra de la relación establecida entre enfermo y médico, entre sujeto que sufre y sujeto que cura; entre enfermo cuyo espíritu ansía los beneficios del alivio y del consuelo y médico cuyo espíritu, convenientemente educado, comprende los anhelos del enfermo y se halla en aptitud de realizarlos cumplidamente.
La atención y su medida. Estudio experimental del test del doctor Valdizán
Authors: Bustamante Ruíz Carlos E.
Published: January 2017

La atención puede ser definida como "el esfuerzo integral del espíritu, que limitando una región determinada en el campo de la conciencia, ilumina vivamente el contenido de ese campo y lo mantiene así, distinto y claro, mientras lo contempla o estudia".
Las lesiones oculares en el tifo exantemático
Authors: Mackehenie Daniel , Giles A. , Alzamora V. V.
Published: January 2017

Aun cuando son, relativamente, incompletas nuestras observaciones sobre este tema debido a la escasez de material patológico y a la condición en que el mismo llegó para su estudio, juzgamos conveniente una descripción para animar a otros observadores nuestros a fin de completar el cuadro anatómico. Otra razón más que no simpele a publicar estos apuntes es el de comparar nunestros resultados con los de varios investigadores y notar sus analogías.
Contribución al estudio de la fisiología del andino - Calcemia y sistema nervioso vegetativo en las altiplanicies andinas
Authors: Palti Víctor
Published: January 2017

El estudio de la Fisiología del Andino, iniciado por el profesor Monge en 1927, y continuado por eminentes investigadores nacionales, constituye uno de los principales temas de investigación en el país.