bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Unicortical Locking Screw Placement Effective For The Torsional Loads in the Distal Radius Fractures? : Biomechanical Study in Cadaver
Authors: Pehlivan Ali Tufan , Oc Yunus , Ertogrul Rodi , KILINC BEKIR ERAY
Published: June 2022

Background
We aimed to compare biomechanical outcomes of short-length (75%-length) and full-length (100%-length) unicortical distal screws under axial and torsional compression in cadaveric distal radius volar plate model.
Methods
A total of 20 wrists from 10 fresh frozen cadavers were included. 2.5 mm titanium alloy distal radius anatomical plates was placed to the distal radii in full anatomical position, just proximal to the watershed line. Three bicortical screws to the shaft of the radius, followed by unicortical drilling for distal screwing were placed. Measurement by pulling the drill once it reached the opposite cortex was applied. We selected the screw lengths such that they corresponded to the 75% of the measured length (short-length). In the same configuration for each of the cadavers, we delivered six screws from distal radius holes of the anatomical plate. oscillating handsaw was used to create extraarticular distal radius fracture model (AO 23-A3.2). We created dorsal AP model by performing a 1-cm wedge osteotomy from dorsal aspect. Complete separation of the volar cortex was achieved. Potting was performed by embedding the shaft of the prepared radius into the polyurethane medium. We placed aluminum apparatus into the distal end to ensure applying of torsional and axial loading in biomechanistic tests.
Results
No statistically significant difference of stiffness between the short-length and full-length distal screws both under axial compression(p = 0.88) and torsional compression (p = 0.82). Short-length and full-length distal screw groups did not differ in elastic limit under axial compression (p = 0.71) and torsional compression (p = 0.71). Maximal force on short-length and full-length distal screw groups were also similar under both axial compression (p = 0.71) and torsional compression (p = 0.50).
Conclusion
It is a safe method under torsional load to avoid drilling of the dorsal cortex and unicortical delivery of 75%-length distal screws could be performed in order to prevent from extensor tendon complications secondary to drilling or screw protrusion.
Spatio-temporal variation of major ion chemistry and nutrient stoichiometry in a tropical monsoonal estuary: Insight into biogeochemical processes
Authors: Akhtar Shaheen , Equeen Sk. Md.
Published: June 2022

Major ions and nutrient chemistry of surface water from the Devi river estuary, eastern India has been studied in order to understand the governing biogeochemical processes. Concentration of Na, K, Ca, Mg, Cl, SO4 and PO4 increases towards higher salinity; however, NO3 and dissolved silica (DSi) decreases from upper to lower estuary. All major ions, except NO3 and DSi, show the highest and lowest concentration in summer and monsoon season respectively. Increased surface runoff has resulted in the highest concentration of NO3 and DSi in the monsoon period. The Na, Cl, SO4, NO3 and PO4 ions show conservative mixing behavior in the estuary throughout the year. Non-conservative behavior of DSi is attributed to the combined process of mineral weathering and biological removal by diatoms. Enrichment and depletion of Ca and Mg in the estuary is owed to carbonate mineral precipitation and dissolution processes. Decreasing carbonate saturation indices (SI) with reducing pH accompanied by lowering of DO% suggests the influence of organic matter degradation on the carbonate precipitation and/or dissolution potential. Nutrient stoichiometric ratios – NO3:PO4, DSi:PO4 and DSi:NO3 – are found to vary spatially and seasonally as a result of differences in geochemical processes prevailing in the fresh- and marine-water environment. A prominent PO4 limitation is observed in the upper estuary during summer and winter. However, this limitation reduces towards the lower estuary owing to precipitation of Fe-sulphide under the influence of higher salinity. In contrast, the influx of PO4-limited freshwater into the estuary controls the nutrient limitation in the monsoon season. The spatial variation of chlorophyll concentration in the estuary is in accordance to the nutrient stoichiometric ratios. Thus, this study emphasizes on the role of unique biogeochemical processes in controlling the spatial and seasonal distribution of major ions and nutrient stoichiometry in a tropical estuarine system.
Endoscopic grading system for predicting anastomotic complications after esophagectomy: a prospective cohort study. (Endoscopic grading system after esophagectomy)
Authors: Kobayashi Shinichiro , Kanetaka Kengo , Yoneda Akira , Yamaguchi Naoyuki , Kobayashi Kazuma , Nagata Yasuhiro , Maruya Yasuhiro , Yamaguchi Shun , Hidaka Masaaki , Eguchi Susumu
Published: June 2022

BackgroundPostoperative complications related to gastric conduit reconstruction are still common issues after McKeown esophagectomy. A novel endoscopic grading system is desired to predict anastomotic complications after McKeown esophagectomy.Aims and MethodsThe purpose of this study was prospectively to evaluate the safety and efficacy of endoscopic examinations of the anastomotic region in the acute period after esophagectomy.Endoscopic examinations were performed on postoperative days (PODs) 1 and 8. The severity of the ischemic area was prospectively validated and classified into four categories according to the novel endoscopic mucosal ischemic grading system (EMIGS). ResultsFifteen patients (25.9%) developed anastomotic complications after esophagectomy. The negative predictive values for anastomotic complications, leakage, and strictures in EMIGS grades C or D were extremely high on POD 8 after esophagectomy (95.1%, 100%, and 95.1%, respectively). In the multivariate analysis, EMIGS grades C or D on POD 8 had a significant correlation with anastomotic complications after esophagectomy (odds ratio [OR]: 67.0; 95% confidence interval [CI]: 6.5-688.4; P < 0.01). EMIGS grades C or D on POD 8 after esophagectomy were associated with developing anastomotic leakage and strictures after esophagectomy in the univariate logistic regressions analysis (OR: 2.1 x 107; 95%CI:9.0 – infinity; P<0.01, OR:35.8; 95%CI:7.5 – 273.4; P<0.01, respectively). ConclusionsThe application of endoscopic classification to mucosal ischemia after McKeown esophagectomy yielded suboptimal accuracy in predicting anastomotic complications.Trial registration: Clinical Trial.gov Registry, ID: NCT02937389, Registration date: Oct 17, 2015
Resolution enhancement using a multi-layered Aluminum- based plasmonic device for chikungunya virus detection
Authors: Shukla Sambhavi , Grover Nitika , Arora Pankaj
Published: June 2022

Biomolecular variations can be accounted for by changes in the intrinsic properties of the surrounding medium, such as the refractive index. This work employs such an arrangement using a modified attenuated total internal reflection configuration for telecommunication wavelength (1550nm). The phenomenon of surface plasmon resonance is initiated by Aluminum (Al) metal due to its low cost and better compatibility with CMOS devices. To achieve improved plasmonic response in terms of the sensor’s resolution, we have explored metal-dielectric-metal configuration under angle interrogation. Barium titanate and Molybdenum disulfide (MoS2) have been employed as the high dielectric constant material and the binding media respectively to enhance the sensing performance. After a series of optimizations, the proposed device configuration leads to a maximum Figure of Merit (FOM) of 540.9 RIU− 1, thus enhancing the resolution. The proposed plasmonic device can be used for chikungunya virus detection by considering different blood components in normal and infected stages. This Al-based multi-layered plasmonic device can serve many applications for resolution enhancement in the near-infrared region.
M5C modulator mediated methylation pattern and TME cell infiltration in bladder cancer
Authors: Yang Zhan , Lang Zhichao , Tao Qiqi , Chen Bo , Li Xiaoqi , Zhan Yating , Zhang Rongrong , Zhu Kai , Yao Zhengze , Gao Yuxiang , Chen Ji , Zheng Jianjian , Li Yeping
Published: June 2022

Background:
In recent studies, the role of modification patterns of N6-methyladenosine (m6A) regulators in tumor microenvironment (TME) cell infiltration in the tumor microenvironment has been identified. However, the role of 5-methylcytosine (m5C) modification patterns in TME cell infiltration remains to be discovered.
Methods:
In this study, 660 bladder cancer patients were enrolled to comprehensively evaluate the m5C modification pattern based on 13 m5C regulators, and to explore the association between m5C modification pattern and TME cell infiltration status. Finally, PRINCIPAL component analysis (PCA) algorithm constructed m5Cscore, which was used to evaluate and quantify individual m5C modification patterns.
Results:
Our study identified three distinct m5C modification patterns in bladder cancer. Studies showed that TME cell infiltration characteristics under these three modification patterns were highly associated with three tumor immunophenotypes (immune-inflamed, immune-excluded, immune-desert). In addition, m5C methylation modification patterns were proved to be able to predict tumor disease progression, genetic variation and prognosis of patients. The individualized scoring system – m5Cscore, which was based on m5C methylation modification, showed great differences in tumor mutation burden (TMB), clinical characteristics, immune checkpoint and immunotherapy. The low m5Cscore group was characterized by matrix activation and lack of effective immune cell infiltration, indicating the immune-excluded phenotype. The higher m5Cscore group showed fewer PD-L1 mutations, which were associated with a promoted response to PD-L1/PD-1 immunotherapy and a better prognosis.
Conclusions:
This work confirmed the extensive regulatory mechanisms of the m5C modification pattern in the tumor microenvironment. The m5C modification pattern functioned as an important element of forming the heterogeneity and complexity of TME landscape. Understanding and in-depth evaluation of individual m5C modification patterns would help us understand the TME landscape and guide better immunotherapy strategies.
Pituitary Function at Presentation and Following Therapy in Patients with Non-functional Pituitary Adenomas: A Single Centre Retrospective Cohort Study
Authors: Hussein Ziad , Marcus Hani J , Grieve Joan , Dorward Neil , Kosmin Michael , Fersht Naomi , Bouloux Pierre Marc , Jaunmuktane Zane , Baldeweg Stephanie E
Published: June 2022

Background:Non-functioning pituitary macroadenomas (NFPMs) may present with hypopituitarism. Pituitary surgery and radiotherapy pose an additional risk to pituitary function.ObjectivesTo assess the incidence of hypopituitarism at presentation, the impact of treatment, and the likelihood of endocrine recovery during follow-up.MethodsAll patients treated surgically with and without radiotherapy for NFPMs between 1987 and 2018 who had longer than 6 months follow-up were identified. Demographics, presentation, investigation, treatment, and outcomes were collected.ResultsIn total, 383 patients were identified. The median age was 57 years with a median follow-up of 8 years. Preoperatively, 235 patients (235/377; 62%) had evidence of at least one pituitary deficiency. Anterior panhypopituitarism was more common in men (p =0.001), older patients (p =0.005), and in those with adenomas extending beyond the sella turcica (p =0.05). Patients treated with surgery and radiotherapy had a higher incidence of all individual pituitary hormone deficiency and anterior panhypopituitarism as well as significantly lower GH, ACTH, and TSH deficiencies free survival probability than those treated with surgery alone. Recovery of central hypogonadism, hypothyroidism, and anterior panhypopituitarism was also less likely to be reported in those treated with surgery and radiotherapy.ConclusionNFPMs are associated with significant degree of hypopituitarism at time of diagnosis and post therapy. The combination of surgery and radiotherapy is associated with higher risk of pituitary dysfunction. Recovery of pituitary hormone deficit may occur after surgical treatment. Patients should have regular ongoing endocrine evaluation post-treatment to assess changes in pituitary function and the need for long-term replacement therapy.
Pollution, Ecological, and Health Risk Assessments of Heavy Metal Remediated Soil by Compost Fortified with Natural Coagulants
Authors: Taiwo Adewale M. , Oladotun Oluwafunbi R. , Alegbeleye Wilfred O , Gbadebo Adewole M.
Published: June 2022

The present study assessed the pollution, ecological, and health risks of heavy metals (HMs) in remediated soils by compost fortified with natural coagulants (Moringa, Neem, and Pawpaw).The polluted soils were mixed with the stabilized composts at varying ratios of 1:200, 1:100, 1:66, and 1:50. Heavy metals(Cu, Zn, Ni, Mn, Cd, and Pb) were determined in compost and soil samples using Atomic Absorption Spectrophotometry. Data collected were analyzed for descriptive and inferential statistics. Removal efficiencies (REs) of HMs by the compost types were also determined. Results showed Mn as the highest observed HM in composts with values ranging from 179.6 ± 1.25 mg kg− 1 in Neem to 206.3 ± 5.01 mg kg− 1 in Moringa. The levels of HMs (except Zn) observed in composts were generally less than the target values expected in unpolluted soil. Application of the three composts to contaminated soils reduced the HMs by 5–37, 17–47, 25–43, 43–57,59–71, and 69–75% for Cd, Cu, Ni, Pb, Mn, and Zn, respectively. Removal of HMs in contaminated soils followed the distribution pattern of Zn > Mn > Pb > Cu > Ni > Cd. All the compost types were effective in cleaning up Mn and Zn in contaminated soils. However, Moringa appeared to indicate the highest removal efficiency followed by Neem and Pawpaw, in that order.
An advance of optimization by Simulated Annealing Algorithm and ANFIS to minimize delamination during drilling Chopped Strand Mat GFRP
Authors: Thangavel Panneerselvam , Sriniva Raghuraman , Vasu Manoj , Panneerselvam Monica
Published: June 2022

Glass Fibre Reinforced Polymer (GFRP) composites are commonly used in many applications, such as in the aerospace, construction, maritime and automotive sectors, owing to their lightweight, corrosion resistant, strong rigidity and lightweight to strength ratios. This form of material normally struggles on machining with surface delamination, fibre peeling up, fibre pulling away, fibre cracking, fibre de-bonding and fibre breaking. There is a need to optimize the drilling parameters specifically in reducing the type of damage known as delamination which is prevalent during drilling activity on Chopped Strand Mat GFRP material. Regression equations for the experimental results collected from drilling Chopped Strand Mat GFRP material are established for this purpose. Considering the established regression equations as objective functions, under parallel search methodology, Simulated Annealing Algorithm employs innovatively to refine the drilling parameters for reduced delamination. Simulated Annealing Algorithm (SAA) is programmed using C + + and the decrement factor, known as the cooling factor applied during the search process, is varied for the parallel search of optimization. Through this optimization strategy, the tailored drilling parameters for drilling Chopped Strand Mat GFRP material with minimal delamination are substantially enhanced, and the performance of SAA are verified by the Adaptive Neuro Fuzzy Inference System (ANFIS).
Prevalence and Associations of Asteroid Hyalosis: The Beijing Eye Study
Authors: Zhang Chuan , Shao Lei , Dong Li , Zhou Wen Da , Zhang Rui Heng , Wei Wen Bin
Published: June 2022

Background: To determine the prevalence and associations of asteroid hyalosis (AH) in a Chinese population-based cohort.Methods: The retrospective, cross-sectional, population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range: 50-93 years). Participants underwent detailed ophthalmic examinations including fundus photographs for diagnosis of AH. Data on systemic and ocular factors were collected for all participants according to the standardized protocol. Multiple linear regression and multivariate Logistic regression analysis were performed.Results: Fundus photographs were gradable in 3419 subjects. AH was detected in 63 (0.9%, 95% CI: 0.7%, 1.1%) eyes of 53 (1.6%, 95% CI: 1.1%, 2.0%) subjects. AH was bilateral in 18.9%. Mean age of all subjects with AH was 69.2± 9.5 years (median, 71.0 years; range, 51–91 years), mean spherical equivalent was 0.63±1.53D (median, 0.75 D; range, -4.12 to 4.00D). In multivariate analysis, prevalence of AH was associated with elder age (P=0.014, OR 1.057), thicker lens (P=0.032, OR 3.887), higher spherical equivalent (P=0.017, OR 1.396).Conclusions: In adult Chinese in Beijing, the prevalence of AH was 0.9% for eyes or 1.6% for subjects. AH was associated with elder age, thicker lens, and higher spherical equivalent. It was not associated with diabetes or other systemic indicators.
Die Kennzeichnungskraft von Akronymen und eine potenzielle stillschweigende Praxisänderung bei der vollständigen Übernahme des älteren Zeichens in die neuere Marke
Authors: Reber Yannick
Published: June 2022

Das Bundesverwaltungsgericht hatte sich anlässlich des Urteils B-1306/2021 vom 1. Februar 2022 – YT//EYT (fig.) mit Akronymen zu befassen und sich zu ihrer Bedeutung im Markenrecht zu äussern. Das Urteil enthält weiter Anhaltspunkte, welche die bisherige Praxis, wonach die integrale Übernahme eines älteren Zeichens in die neuere Marke markenrechtlich grundsätzlich unzulässig ist, in Frage stellen. Das Urteil verdient zwar im Ergebnis Zustimmung, vermag aber in den zugrunde liegenden rechtlichen Ausführungen nicht durchgehend zu überzeugen.

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A l'occasion de l'arrêt B-1306/2021 du 1er février 2022 - YT//EYT (fig.), le Tribunal administratif fédéral a dû se pencher sur les acronymes et se prononcer sur leur signification dans le droit des marques. L'arrêt contient en outre des éléments qui remettent en question la pratique actuelle selon laquelle la reprise intégrale d'un sigle antérieur dans la marque plus récente est en principe inadmissible du point de vue du droit des marques. Bien que le résultat de l'arrêt mérite d'être salué, les explications juridiques qui le sous-tendent ne sont pas entièrement convaincantes.
Debates contemporáneos en derecho de familias, de infancias y de adolescencias: Retos y oportunidades
Authors:   Universidad Católica Luis Amigó, Roldán Villa Ana María , Vásquez Santamaría Jorge Eduardo ,   Universidad Católica Luis Amigó
Published: June 2022

Debates contemporáneos en derecho de familias, de infancias y de adolescencias. Retos y oportunidades es producto del ejercicio riguroso de las autoras, quienes, a partir de sus afinidades personales y profesionales, contribuyen al quehacer científico y al entendimiento de asuntos actuales como los obstáculos de las mujeres trabajadoras y el fuero de la maternidad, la interrupción voluntaria del embarazo, la alienación parental y los proyectos de reformas del código civil sobre el derecho de familia desde un enfoque jurisprudencial. La presente obra es la segunda edición del texto Debates del derecho de las familias, infancias y adolescencias. Desafíos y realidades, ambos trabajos constituyen una apuesta investigativa por ilustrar a los lectores sobre las múltiples y complejas realidades del derecho de las familias, infancias y adolescencias, disciplina en constante evolución.
Kanto’s Guest House Business Competitive Strategic Analysis for Sustainable Income
Authors: Rosita Ameliya
Published: June 2022

This research aims to formulate and select Kantos House (KH) - Guest House strategy to face the competitive market in hotel accommodation industry for optimizing  sustainable income through (1) evaluated brand awareness of KH; (2) identified external and internal factors that significant related to KH business, (3) analyzed brand effectiveness and competitive advantages of KH for optimizing sustainable income. This research method used Kapferer’s Prism for analyzing KH brand identity, multichannel online review for analyzing consumer feedback of output average score of company’s hotel score review, room occupancy company report for analyzing average rate of KH’s occupancy, and SWOT diagram analysis. The result of this research shows currently the design of company brand has accomplished all the six criteria based on Brand Identity Prism, unfortunately the brand awareness still on low level. This resulted related due to the absence of brand marketing communication company’s budget. Customer Review currently is very important for company, which proof by the management’s commitment to maintain the average rate of KH online review at least or more than 4,4 of  5 star “very good” (Google rating version), also by opening review channels for customer feedback by putting the sticker  for TripAdvisor review on the wall near the lobby hotel also via online by adding  sub- menu  for the review purposed. The average level of KH’s room occupancy from 2017 until November 2018 was 82% and on 2017 was 87%. This result is favorable which the company’s position highly above of the Indonesian hotel’s average room occupancy in 2017 was on 65% (BPS 2017). The SWOT analysis result showed the position of KH was in the 1st quadrant means company on healthy condition which the suitable competitive strategy is growth or aggressive strategy.
Analysis Influence of NPL, Good Corporate Governance, and BOPO to Stock Prices on National Private Bank Period 2012 - 2018
Authors: Winoto Agustinus , Purba Hendryan Tua Marudut
Published: June 2022

The level of performance of a bank has many factors that affect that stock prices, including internal factor from the bank itself. The purpose of this research is to analyse the  Non-performing Loan, Good Corporate Governance, and Beban Operasional Pendapatan Operasional (BOPO) affect to stock prices simultaneously or partially on the national private private banks listed on the Indonesia Stock Exchange period 2012-2018. The sample in this study was 21 national private banks listed on the Indonesia Stock Exchange period 2012-2018. Data analysis model used is panel data regression using the software E-views 10. The results of this study indicate simultaneously the independent variables namely NPL, GCG and BOPO have a significant effect on stock prices in national private banks period 2012-2018, NPL have a significant effect on stock prices at national private private banks period 2012-2018, whereas GCG and BOPO do not significant effect on stock prices on the national private private bank period 2012-2018.
How to Develop Learning Styles to Encourage Gen Zers in Their Academic Performance and Workforce
Authors: Paulina Christine , Ernawati Endang
Published: June 2022

The research aimed to find out the support of information communication and technology (ICT) to encourage generation Z  (Gen Zers) in their learning style in academic environment as well as a preparation for their competences to enter the workforce. The research applied a qualitative method with literature study style. The studied literature consisted of primary sources such as articles, scientific papers, and the secondary sources, such as books, and some other internet sources. The literatures were comprehended by reading, understanding, analyzing, and synthesizing them to produce new findings in the form of information from various studied sources.   Data analysis was done by using content analysis method by selecting, comparing, and combining various information so that the relevant knowledge was found to clarify the learning style needed by generation Z. The results indicate that generation Z learners like to use social media in the learning process and to interact with friends and teachers. In a higher education context, technological tools are utilised for online learning. The combination of digital tools in teaching-learning process and a suitable materials for generation Z learners is also important as it will engage students in the learning process. In entering the future workforce, generation Z learners are equipped with knowledge, skills, and competencies in English to support them in finding jobs locally and regionally.
The Highest Retail Price Checker for Web Based Medical Equipment and Necessities
Authors: Nugroho Muhammad Daffa
Published: June 2022

In the business world that is in medical equipment and staples for customers, the availability and also the need for data is also very important. As time goes on, the data is getting more diverse, which makes various products that are uniform but have significant price differences. This triggers confusion for customers to choose a product, so a price checking application is needed. The purpose of this report is to create a price comparison website application that displays the best prices for medical equipment products and staples. The data collection methodology uses Ideation which collects related journals, books, and credible sources. The application design methodology uses the Waterfall method for web development and maintenance. Product data retrieval is done by using the HTML Web Scraping method. How to test the application is done by Alpha Testing and Beta Testing and also Checking Input Output with BlackBox Testing. From the results of data collection and Web Development PriceCheck provides benefits where customers can find out the best price for the product they are looking for which is also available at the right store.
Implementation, Provision, and Protection of Human and Civil Rights and Freedoms by Municipal Public Authorities
Authors: Trescheva Oksana
Published: June 2022

This article introduces solutions to some topical problems of legal regulation of human and civil rights by municipal public authorities. The research featured constitutional, municipal, and other sectoral norms that regulate the actions of municipal authorities in providing human and civil rights and freedoms. The list of general scientific and special methods included the system analysis, the method of analogy, the comparative legal analysis, the legal forecasting, etc. The resulting proposals can improve certain legal provisions in this sphere, thus improving the quality of life in the Russian Federation.
Pedagogical Model of Forming Cross-Cutting Digital Competences in Students of Supplementary Higher Education
Authors: Achkasova Oksana
Published: June 2022

The Workforce for Digital Economy Federal Project is aimed at developing professional competencies in the field of cross-cutting digital technologies. Digital economy competences depend on the requirements of potential employers, as well as on those of society, state, and labor market. The article introduces the definition of cross-cutting digital competences and describes their basic, personal, and professional components. The author constructed a pedagogical model of developing cross-cutting digital competences in students of supplementary higher education. The model includes goals, objectives, pedagogical principles, internal and external factors, content components, organizational foundations, and pedagogical conditions.
Unilateral Adrenal Infarction in Pregnancy: A Case Report
Authors: Hajjaji Awatef , Jemma Yosra , Mnejja Amina , Zouari Ines , Ghaddab Imen , Jebali Fethi , Gratti Lotfi , Faleh Raja
Published: June 2022

Adrenal infarction is usually associated with bilateral adrenal hemorrhage in the setting of antiphospholipid syndrome or hemodynamic variation. Few cases of unilateral non-hemorrhagic adrenal infarction have been described in the literature. Here, we report a case occurring during pregnancy. A 27-year-old woman was infected by coronavirus four months ago and presented at 35 weeks of gestation with sudden-onset right abdominal pain without contractions. Unilateral adrenal infarction was diagnosed following computed tomography. It showed an enlarged right adrenal, without hyperenhancement. The patient’s adrenal hormonal function was normal. Accurate diagnosis of non-hemorrhagic adrenal infarction remains difficult as its clinical presentation is not specific. It can only be performed with adrenal imaging. Magnetic resonance imaging shows diffuse enlargement of one or both adrenals and edema on T2-weighted images. Anticoagulation therapy may be discussed. Patients should be evaluated between 3 and 6months after the event to assess adrenal size and function. In summary, non-hemorrhagic adrenal infarction during pregnancy is probably underdiagnosed and obstetricians should be aware of this diagnostic difficulty.
Guía para la atención y promoción de la adherencia terapéutica en pacientes diabéticos basado en un modelo psicoeducativo
Authors: Caballero Domínguez Carmen C. , Campo Arias Adalberto , Perdomo Rojas José Andrés , Fuentes López Carlos Mauricio , Escalante María Laura , Celis Ana María
Published: June 2022

La presente cartilla es un producto de divulgación de la estrategia de apropiación social del conocimiento derivada de la investigación Programa de adherencia al tratamiento en pacientes diagnosticados con Diabetes Mellitus tipo 2 (DM2) basado en el modelo transteórico. Esta investigación fue financiada por la Universidad del Magdalena en cofinanciación por el Ministerio de Ciencia Tecnología e Innovación, mediante la convocatoria 850 que hizo posible realizar la actividad de apropiación social del conocimiento, a través de la vinculación de jóvenes investigadores. La cartilla recoge las percepciones, creencias y conocimientos prácticos de los participantes con diagnóstico DM2 en torno a la adherencia al tratamiento que participaron en el estudio; se integran al conocimiento científico para brindar recomendaciones a los profesionales de la salud que aporten a la mejora de la adherencia al tratamiento y a la atención de esta población.
Sydnone: Synthesis, Reactivity and Biological Activities
Authors: Zerbib Souad , Khouili Mostafa , Catto Marco , Bouissane Latifa
Published: June 2022

Sydnones are among the most well-known mesoionic compounds. Since their
synthesis in 1935 by Earl and Mecknay, numerous researches have shown that the chemical
behavior, physical and biological properties of sydnones make them the most useful
compounds in organic chemistry. Sydnones undergo thermal 1,3-dipolar cycloaddition reaction
with dipolarophiles (alkynes or alkenes) to give exclusively derivatives containing
a pyrazole moiety exhibiting numerous applications, such as pharmaceuticals and agrochemicals.
However, the sydnone cycloaddition reaction with alkynes requires harsh conditions,
like high temperatures and long reaction times, giving poor regioselectivity to the
resulting products. To overcome these constraints, new reactions named CuSAC (Copper-
Catalyzed Sydnone-Alkyne Cycloaddition) and SPSAC (Strain-Promoted Sydnone-
Alkyne Cycloaddition) have been developed, leading to pyrazoles with interesting constant
kinetics.
Rationally-designed Chitosan-based Polymeric Nanomaterials
According to Intrinsic Characteristics for Cancer Therapy and
Theranostics: A Review
Authors: Yu Fangying , Zhu Yun , Shang Xuwei , Yuan Hong , Hu Fuqiang
Published: June 2022

Chitosan, the only naturally occurring polycationic polysaccharide derived
from chitin, has long case been implicated in the designs of nanosystems for diverse
biomedical and pharmaceutical applications owing to its exclusive biodegradability, biocompatibility, cationic property, and functional groups. Particularly, some intrinsic characteristics of chitosan equip it with high potential for facile preparation, flexible functionalization, and modification, which circumvent the defects of chitosan and account for extensive attempts in cancer therapy and theranostic. In this review, we first give a classifiable explanation of strategies in fabricating rationally-designed chitosan-based polymeric
nanomaterials for cancer therapy, which are categorized by the physical, chemical, and biological intrinsic characteristics of chitosan, respectively. Specifically, examples harnessing the cationic charge of chitosan are clarified, and the accompanied pH-responsive ability functions frequently are also mentioned. Besides, strategies toward the modification
of functional groups (amino and hydroxyl groups) in repeated glycosidic units of chitosan and their additional roles are also discussed here. Lastly, the biological superiority
of chitosan as an adjuvant or a ligand for glycoprotein and the application of chitosan-based polymeric nanomaterials in theranostic are summarized. Altogether, this review provides a comprehensive overview of recent advances in chitosan-based polymeric
nanomaterials for cancer therapy and theranostics from a brand new perspective.
Bioactive Compounds from Polar Regions: An Account of Chemical Ecology and Biotechnological
Applications
Authors: Singh Archana , Singh Keisham S.
Published: June 2022

Organisms living in polar regions experience harsh environmental conditions. To cope and adapt to the extreme climatic conditions, the organisms produce specialized metabolites. The metabolites produced by polar organisms exhibit various biological activities and thus find application in the pharmaceutical, food and cosmetic industries. Numerous secondary metabolites have been isolated from polar organisms that exhibited interesting biological properties. With ongoing climate change and the opening up of the polar regions for resource exploration, it is important to realise the natural product potential and scope of the regions. This review describes a brief account of bioactive compounds reported from polar organisms along with their ecological perspective and biotechnological applications. We present a detailed overview of the chemicals structures of the compounds isolated from polar regions, which are grouped into usnic acid, MAAs, asterric acids, depsides, depsidones and psedodepsidones, alkaloids, polysaccharides and EPS. We have also discussed the ecological significance of the compounds, covering a general aspect as well as a specific account, wherever reported, along with bioactivities. The review covers the literature report from 2010 to 2020.
Addition of Mercury Causes Quenching of NIR Fluorescence Emission Spectra of a Photoactivatable PAiRFP1 Protein
Authors: Hassan Fakhrul , Khan Faez Iqbal , Juan Feng , Khan Abbas , Lai Dakun
Published: June 2022

Background:

Biliverdin (BV) containing far-red light photoactivatable near-infrared fluorescent protein (NIR-FP) named PAiRFP1 has been developed by directed molecular evolution from one bathy bacteriophytochrome of Agrobacterium tumefaciens C58 called Agp2 or AtBphP2. Usually, the fluorescence intensity of the NIR emission spectra of PAiRFP1 tends to increase upon repeated excitation by far-red light.

Objective:

This study aimed at exploring the role of PAiRFP1 and its mutants, such as V386A, V480A, and Y498H, as NIR biosensors for the detection of Hg2+ ions in the buffer solutions.

Methods:

In this study, we used PCR-based site-directed reverse mutagenesis, fluorescence spectroscopy, and molecular modeling approaches on PAiRFP1 and its mutants.

Results:

It was found that PAiRFP1 and its mutants experienced strong quenching of NIR fluorescence emission spectra upon the addition of different concentrations (0-3μM) of mercuric chloride (HgCl2).

Conclusion:

We hypothesized that PAiRFP1 and its variants have some potential to be used as NIR biosensors for the in vitro detection of Hg2+ ions in biological media. Moreover, we also hypothesized that PAiRFP1 would be the best tool to use as a NIR biosensor to detect Hg2+ ions in living organisms because of its higher signal-to-noise (SNR) ratio than other infra-red fluorescent proteins.
Systematic Review of the Serotonergic System in the Pathophysiology of
Severe Dengue: The Theory of Thrombocytopenia and Vascular Extravasation
Authors: Briones-Aranda Alfredo , Corzo-Gómez Josselin , Picazo Ofir , Castellanos-Pérez Manuela
Published: June 2022

Background: Severe dengue is characterized by thrombocytopenia, hemorrhaging,
and/or capillary extravasation and may be linked to a reduced plasma concentration of serotonin
(5-hydroxytriptamine, or 5-HT).

Objective: The aim of the current contribution was to conduct a systematic bibliographic review of
reports on the role of the peripheral serotonergic system in the pathophysiology of severe dengue.

Methods: A bibliographic review was carried out of in vivo/in vitro models, clinical trials, and
case series studies from 2010-2019. The selective criteria were the use of treatments with serotonin
reuptake inhibitors and/or agonists/antagonists of 5-HT receptors and their impact on inflammation,
coagulation, and endothelium. Moreover, cross-sectional and cohort studies on the relationship
between intraplatelet and plasma 5-HT levels in patients with dengue were also included.
The risk of bias in the selected reports was examined with domain-based assessment utilizing
Cochrane-type criteria. The main results are summarized in Tables and Figures.

Results: Based on descriptions of the effect of serotonergic drugs on 5-HT levels and the findings
of clinical trials of dengue treatment, most receptors of the peripheral serotonergic system, and
especially 5-HT2A, seem to participate in regulating serum 5-HT during severe dengue. Therefore,
the peripheral serotonergic system probably contributes to thrombocytopenia and capillary extravasation.

Conclusion: Regarding dengue, 5-HT may be a key parameter for predicting severity, and an understanding
of 5-HT-related mechanisms could possibly facilitate the development of new therapies.
These proposals require further research due to the limited number of publications on the role
of serotonergic receptors at the peripheral level.
Association of SARS-CoV-2 Infection and Triple Negative Breast Cancer (TNBC) A Computational Illustrative Study
Authors: Vyshnavi A. M. Hima , Namboori P. K. Krishnan
Published: June 2022

Background:

Anticipating the correlation between SARS-CoV-2 infection and ‘triplenegative breast cancer (TNBC)’ remains challenging. It has been reported that people currently diagnosed with cancer have a higher risk of severe complications if they are affected by the viral infection. Cancer treatments, including chemotherapy, targeted therapies, and immunotherapy, may weaken the immune system and possibly cause critical lung damage and breathing problems. Special attention must be paid to the ‘comorbidity condition’ while estimating the risk of severe SARSCoV- 2 infection in TNBC patients. Hence the work aims to study the correlation between triplenegative breast cancer (TNBC) and SARS-CoV-2 using biomolecular networking.

Methods:

The genes associated with SARS CoV-2 have been collected from curated data in Bio- GRID. TNBC-related genes have been collected from expression profiles. Molecular networking has generated a Protein-Protein Interaction (PPI) network and a Protein-Drug Interaction (PDI) network. The network results were further evaluated through molecular docking studies followed by molecular dynamic simulation.

Results:

The genetic correlation of TNBC and SARS-Cov-2 has been observed from the combined PPI of their proteins. The drugs interacting with the disease's closely associated genes have been identified. The docking and simulation study showed that anti-TNBC and anti-viral drugs interact with these associated targets, suggesting their influence in inhibiting both the disease mutations.

Conclusion:

The study suggests a slight influence of SARS-CoV-2 viral infection on Triple Negative Breast Cancer. Few anticancer drugs such as Lapatinib, Docetaxel and Paclitaxel are found to inhibit both TNBC and viral mutations. The computational studies suggest these molecules are also useful for TNBC patients to control SARS-CoV-2 infection.
Sex-Related Differences Linked to Depression Disorders and Chronic Inflammation
Diseases in Nursing Shift Workers: An Expsloratory Multidimensional
Literature Review
Authors: Antonino Calabrò , Vitale Elsa , Bardone Lorenzo
Published: June 2022

Objective:

The objective of this literature review is to explore how depression and inflammatory
conditions relate to gender among nurses working shifts.

Method:

Relevant studies available on the PubMed database over the past decade were consulted.
The main keywords were: “shift nurses”, “depression”, “gender Shift Nurses”, “Gender Role”,
“shift nurse”, “gender roles”, “Inflammation” and then, free terms were combined with the Boolean
AND operator. Inclusion and exclusion criteria had been formerly identified, and then, all the selected
studies were assessed according to the following criteria, good description, and appropriateness
of study design (objective and method), sample (sufficiently numerous, clarity of treatment
allocation criteria, absence of important bias), intervention, outcomes, statistical analysis, and clinical
relevance.

Results:

61 titles concerning research on inflammation were found. 28 titles were not taken into
account as doubles whilst 33 were selected by title and abstract; in addition, 28 were discarded
because they were not relevant to the objective or because they did not meet the inclusion criteria.
Out of the remaining 5, a further 2 were also discarded upon a careful analysis of the whole text:
they did not prove relevant to the research question. As for the research related to depression, the
research strategy highlighted 186 articles in the first place and then eliminated 165 of them either
because they were duplicates or on the grounds that they did not answer the research questions; 21
texts were thoroughly analyzed and, after a careful read, 4 studies were eventually incorporated in
this review.

Conclusion:

Since data available in the literature were inconsistent, it was difficult to establish that
all depression conditions could be associated with an increase in inflammation and vice versa and
that this condition was strictly connected to the female gender.
Edible Vaccine - An Effective Way for Immunization
Authors: Singhal Divyanshi , Mishra Rashmi
Published: June 2022

Edible vaccines are cost-effective, easy to take, storable as well as bio friendly. If we take it orally, it proves it is capable agents for lessening the occurrence of several diseases like HPV, Norwalk as well as Polio. They are gotten by incorporate a specific quality which is of our enthusiasm into the plant, which creates the attractive encoded protein. These particular encoded proteins furnish the mucosal movement alongside resistance. There are different food items that are utilized as elective specialists for injectable antibodies, for example, wheat, rice, bananas, lettuce, potatoes, tomatoes. In this way, they defeat all the issues related with conventional antibodies and it demonstrates that palatable immunizations is best substitutes to the customary antibodies.
Correlation of the Oral Health Scoring-based Pregnant Oral Self-Care – package (POSC-p) Model with the Motivation to Seek Oral Health Treatment in Pregnant Women
Authors: Suwargiani Anne Agustina , Aripin Dudi , Arief Erry Mochamad , Djustiana Nina , Usri Kosterman , Tjahajawati Sri , Cahyanto Arief , Widyaputra Sunardhi , Susilawati Sri , Abdulkadir Rahimah
Published: June 2022

Background:

Uncomprehensive oral health evaluation instruments and measurement and the low motivation for seeking dental and oral treatment for pregnant women; all require comprehensive measurement instruments that will increase the motivation for seeking oral health treatment for pregnant women. POSC-p model was developed for the Oral Health Scoring (OHS) to assess pregnant women's perceived needs, clinical examination, and salivary state.

Objectives:

The research objective was to analyse the correlation between the POSC-p model with the motivation for seeking oral health care in pregnant women.

Methods:

Cross-sectional research was conducted by a non-probability sampling technique using the consecutive sampling method. The sample size was determined based on the correlation analysis sample size calculation formula. The study variables were POSC-p model built with three dimensions; POSC-p score section 1 was felt needs, POSC-p score section 2 was normative needs, and POSC-p score section 3 was saliva condition. In addition, motivation to seek treatment with intrinsic and extrinsic motivation dimensions. All data were analysed using the Spearman rank correlation test.

Results:

A significant correlation was found between the POSC-p model with intrinsic and a combination of treatment-seeking motivation (p=0.026); a combined score of the POSC-p model with intrinsic (p=0.008) and a combination of treatment-seeking motivation (p=0.032).

Conclusion:

There is a correlation between the POSC-p with motivation for seeking oral health treatment in pregnant women.
The Predictive Role of IQ, Mood, Emotional Reactivity, and Effortful Control on Working Memory among Hafidz Qur’an
Authors: Hurriyati Evi Afifah , Fitriana Efi , Cahyadi Surya , Srisayekti Willis
Published: June 2022

Memorizing the Qur’an is one of the working memory activities as several factors influence the activity of memorizing the Qur’an. However, some argue that memorizing the Qur’an would rather be influenced by the efforts made to maintain perseverance, attention, and mood than the level of individual intelligence. The purpose of this study was to examine the predictive role of the variables in working memory among the Qur’an memorizer, who is called hafidz. This study involved 169 participants from two different universities that hold Tahfidz Qur’an between the age of 17 and 25 were selected from. The participants were asked to fill out four questionnaires (Mood, Emotional Reactivity, Effortful Control, and Working Memory) and paper-and-pencil based IQ test. Based on multiple regression analysis performed, this study found that effortful control was the most significant predictor to working memory, attention and executive within working memory. Effortful attention likewise predicted working memory, attention and execution within working memory. In addition, this study showed that, except emotional reactivity, the other independent variables were the predictors of working memory or its dimensions.
Importancia de la alimentación animal en el sector agroindustrial
Authors: Quintero Serna César Augusto
Published: June 2022

The production process of animal feed is part of a chain of activities ranging from the production and importation of raw materials to the results of animal exploitation. In Colombia, the manufacture of animal feed has grown to levels that exceed the average production of the manufacturing industry and make the agro-industrialsector one of the most influential in the country's economy. With the growth of the agroindustry, it is expected to meet the human food requirements in the national territory, which are insufficient to achieve a well-nourished population. With a global focus on cleanerproduction, environmental control policies, and the use of biomass as an alternative food source to the conventional one; the balanced feed industry is one of the best investment alternatives that allow taking advantage of the by-products of rice mills, corn mills, sugar mill by-products such as molasses, barley bran and yeast in breweries, meat, leather, tallow, pre-mixed viscera, blood meal, feathers and bones of animal by-products. All those by-productsor residues of the industrial process impact the environment in a negative way. The availability of these by-products for animal feed helps to improve the environmental impact and to give a value toa waste whose properties were unknown, and that today is sold at reasonable prices to be used productively in animal feed.