bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase III, randomized, multicenter, open-label study of venetoclax or pomalidomide in combination with dexamethasone in patients with t(11;14)-positive relapsed/refractory multiple myeloma.
Authors: Mateos Maria-Victoria , Moreau Philippe , Dimopoulos Meletios A. , Hong Wan-Jen , Cooper Scott , Yu Yao , Jalaluddin Muhammad , Ross Jeremy A. , Karve Sudeep , Coppola Sheryl , Maciag Paulo Cesar , Bueno Orlando , Arriola Emma Louise , Kumar Shaji
Published: May 2020

TPS8554

Background: BCL-2 is an anti-apoptotic protein important for myeloma cell survival. Venetoclax (Ven) is a highly selective, potent, oral BCL-2 inhibitor, that has shown promise in clinical studies as monotherapy or in combination with other agents in patients with t(11;14)-positive relapsed/refractory multiple myeloma (RRMM; Kumar et al. Blood. 2017; Costa et al. ASH 2018. Abstr. #303; Harrison et al. ASH 2019. Abstr. #142; Bahlis et al. ASH 2019. Abstr. #925; Kaufman et al. ASH 2019. Abstr. #926). Notably, t(11;14)-positive MM is more dependent on BCL-2 for cell survival, which, together with these clinical data, suggests that Ven combined with dexamethasone (Dex) may provide greater clinical benefit versus standard therapies, like pomalidomide (Pom), in this biomarker-defined patient population. This ongoing Phase 3 study (CANOVA; NCT03539744) aims to evaluate the safety and efficacy of VenDex vs PomDex in t(11;14)-positive RRMM. Methods: Eligible patients (≥18 years) must have t(11;14)-positive RRMM per central lab, an ECOG performance status ≤2, received ≥2 prior lines of therapy, previously received a proteasome inhibitor, and must be refractory to lenalidomide and last line of therapy. Patients cannot have history of treatment with Ven, Pom, or other BCL-2 inhibitors. Patients will be randomized 1:1 to Ven (800 mg orally, once-daily) or Pom (4 mg orally, once-daily on days 1-21 of 28-day cycles). Patients in both groups will receive 40 mg Dex (20 mg for patients ≥75 years) once weekly. Treatment will continue until disease progression, unacceptable toxicity, or withdrawal from study. Patients will be stratified based on age at randomization ( < 65 vs ≥65 years), prior lines of therapy (2 to 3 vs ≥4), and International Staging System stage at screening (I vs II vs III). The primary endpoint is progression-free survival (PFS) per independent review committee (IRC) assessment based on International Myeloma Working Group criteria. The final PFS analysis will be performed when approximately 147 PFS events per IRC are observed. Secondary endpoints are response rate, patient-reported outcomes, overall survival, duration of response, times to response and progression, minimal residual disease negativity rate, safety, and Ven pharmacokinetics. Approximately 244 patients will be enrolled; as of January 21, 2020, 28 patients have been randomized (from 19 sites in 12 countries) and enrollment is ongoing. Clinical trial information: NCT03539744 .
CANOPY-A: A phase III, multicenter, randomized, double-blind, placebo-controlled trial evaluating canakinumab as adjuvant therapy in patients (pts) with completely resected non-small cell lung cancer (NSCLC).
Authors: Garon Edward B. , Ardizzoni Andrea , Barlesi Fabrice , Cho Byoung Chul , De Marchi Pedro , Goto Yasushi , Kowalski Dariusz M. , Lu Shun , Paz-Ares Luis G. , Spigel David R. , Spira Alexander I. , Thomas Michael , Leung Mimi , Baum Jason , Zhu Zewen , Oliveira Portella Maria do Socorro , Yang James Chih-Hsin
Published: May 2020

TPS9075

Background: In the CANTOS study, canakinumab (selective IL-1β inhibitor) treatment was associated with reduced incidence and mortality from NSCLC in pts with stable post-myocardial infarction with elevated high-sensitivity C-reactive protein (hs-CRP) levels. In CANOPY-A study, we investigate the therapeutic role of canakinumab in NSCLC. Methods: The CANOPY-A study (NCT03447769) is evaluating the efficacy and safety of canakinumab as adjuvant therapy in adult pts with completely resected NSCLC. Pts with AJCC/UICC v.8 stages II–IIIA and IIIB (T > 5 cm, N2), any histology, completely resected (R0) NSCLC who completed adjuvant cisplatin-based chemotherapy (≥2 cycles) and radiotherapy (if applicable) are eligible. Pts must not have had prior neoadjuvant chemotherapy or radiotherapy. Pts (~1500) are randomized 1:1 to receive canakinumab (200 mg Q3W, SC) or placebo (Q3W, SC) for 18 cycles or until disease recurrence as determined by investigator, unacceptable toxicity, treatment discontinuation at the discretion of the investigator or patient, start of a new antineoplastic therapy, death, or loss to follow-up. Randomization is stratified by AJCC/UICC v.8 stage (IIA vs IIB vs IIIA vs IIIB with T > 5 cm, N2 disease), tumor histology (squamous vs non-squamous), and region (western Europe and North America vs eastern Asia vs rest of the world). Primary objective: disease-free survival (DFS) per local investigator assessment. Secondary objectives: overall survival (OS), lung cancer specific survival, safety, pharmacokinetics, immunogenicity, and patient reported outcomes. Adult pts with stage IIA–IIIA, IIIB (N2 disease only) NSCLC who are candidates for complete resection surgery (and therefore prospective candidates for the main study) will be asked to participate in a biomarker sub-study to understand how resection may impact biomarkers involved in the IL-1β inflammatory pathway and mutations present in blood. In the sub-study, the levels of hs-CRP, other cytokines, and additional biomarkers in blood will be assessed at pre- and post-surgery (endpoint: summary statistics of hs-CRP and other pharmacodynamics [PD] biomarkers). For pts who will enroll in the main study, possible associations between pre- and post-surgery biomarker levels with canakinumab efficacy will be assessed (endpoint: DFS and OS by hs-CRP and other PD biomarkers). The CANOPY-A study is currently enrolling. As of Jan 13, 2020, there are 307 study locations. Clinical trial information: NCT03447769.
Checkmate 77T: A phase III trial of neoadjuvant nivolumab (NIVO) plus chemotherapy (chemo) followed by adjuvant nivo in resectable early-stage NSCLC.
Authors: Cascone Tina , Provencio Mariano , Sepesi Boris , Lu Shun , Aanur Nivedita , Li Sunney , Spicer Jonathan
Published: May 2020

TPS9076

Background: Although surgery for early NSCLC is potentially curative, 5-year overall survival (OS) rates for patients with stage IIA–IIIB disease are historically < 50%, representing a population of high unmet need. Conventional neoadjuvant or adjuvant chemo provides only a 5% absolute improvement in OS at 5 years. A rational approach to improve survival in these patients is to eradicate micrometastatic disease and potentially induce anti-tumor immunity to minimize the risk of relapse with peri-operative regimens including NIVO, a fully human anti–programmed death receptor-1 antibody. Early phase trials indicate that NIVO-based regimens have the potential to deepen pathological responses and extend survival in this setting (Reuss JE et al. Poster presentation at ASCO 2019. Abstract 8524; Cascone T et al. Oral presentation at ASCO 2019. Abstract 8504; Provencio M et al. Oral presentation at WCLC 2019. Abstract OA13.05). Data from the phase 2 single-arm NADIM trial (NCT03081689) demonstrated the highly encouraging major pathological response (MPR) rate of 83% with neoadjuvant NIVO plus chemo followed by adjuvant NIVO in patients with resectable stage IIIA NSCLC (Provencio M et al. Oral presentation at WCLC 2019. Abstract OA13.05). These results require validation in a large randomized controlled study. CheckMate 77T (NCT04025879) is a phase 3, randomized, double-blind trial evaluating neoadjuvant NIVO plus chemo followed by adjuvant NIVO in resectable early stage NSCLC. Methods: Approximately 452 patients aged ≥ 18 years with resectable stage IIA–IIIB (T3N2 only) NSCLC, ECOG performance status 0–1, and available lung tumor tissue will be enrolled at 113 sites in North America, South America, Europe, Asia, and Australia. Patients with EGFR/ALK mutations, brain metastasis, prior systemic anti-cancer treatment or radiotherapy, and autoimmune disease are excluded. Patients will be randomized to receive neoadjuvant NIVO plus carboplatin- or cisplatin-based doublet chemo followed by surgery and adjuvant NIVO, or neoadjuvant placebo plus carboplatin- or cisplatin-based doublet chemo followed by surgery and adjuvant placebo. The primary endpoint is event-free survival, assessed by blinded independent central review. Secondary endpoints include OS, pathological complete response and MPR assessed by blind independent pathological review, safety and tolerability. The start date was September 2019. The estimated primary completion date is May 2023. Clinical trial information: NCT04025879.
A phase III trial-in-progress called REPLATINUM that compares RRx-001 + a platinum doublet to a platinum doublet in third-line or beyond small cell lung cancer.
Authors: Morgensztern Daniel , Huang Chao Hui , Rolfo Christian Diego , Ruckdeschel John C. , Dragnev Konstantin H. , Aljumaily Raid , Hauke Ralph J. , Mekhail Tarek , Fidler Mary J. , Hamm John Turner , Chiappori Alberto
Published: May 2020

TPS9083

Background: Despite several recent checkpoint inhibitor approvals extensive stage small cell lung cancer (SCLC) is associated with a poor prognosis and remains an area of high unmet need. RRx-001 is a first-in-class, minimally toxic small molecule immunotherapeutic that inhibits c-Myc, downregulates the antiphagocytic checkpoint, CD47, repolarizes tumor associated macrophages (TAM) from protumor M2 to antitumor M1 and resensitizes to previously active first line therapies. On the basis of favorable results from a Phase 2 trial called QUADRUPLE THREAT (NCT02489903) in combination with a platinum doublet in later line SCLC, a Phase 3 trial called REPLATINUM was started in 3rd line or beyond SCLC in Q4 2019. Enrollment is ongoing. Methods: This US-based, open-label, randomized, phase 3 study (NCT03777657) compares RRx-001 4mg + a platinum doublet (carboplatin or cisplatin + etoposide) versus a platinum doublet for pts with 3rd line or beyond SCLC that have previously received a checkpoint inhibitor. Approximately 120 pts from 25 centers will be randomized 1:1 to receive RRx-001 4 mg in combination with a platinum doublet vs. a platinum doublet. The platinum doublet will be administered on both arms for up to 4 cycles; on the RRx-001 arm only patients with stable disease or better are eligible to continue on RRx-001 4 mg + carboplatin AUC 2-4 maintenance therapy. If radiologic progression occurs on the control arm prior to the 4th cycle, patients are eligible to crossover to the RRx-001 treatment arm. PFS is the primary endpoint. Secondary endpoints include OS and ORR. Exploratory endpoints include c-Myc, CD-47 and PD-L1 on circulating tumor cells and SIRP-alpha expression on circulating monocytes. Clinical trial information: NCT03777657.
A phase II trial of durvalumab (MEDI4736) and tremelimumab with chemotherapy in metastatic EGFR mutant non-squamous non-small cell lung cancer (NSCLC) following progression on EGFR tyrosine kinase inhibitors (TKIs) (ILLUMINATE).
Authors: Lee Chee Khoon , Subramaniam Shalini , Mersiades Antony , Mitchell Jenna , Jurkovic Hannora , Walker Mariya , Le Loc , Brown Chris , Solomon Benjamin J. , John Tom , Stockler Martin R. , Liao Bin-Chi , Yang James Chih-Hsin , Chiu Chao-Hua
Published: May 2020

TPS9631

Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have proven remarkably effective in the treatment of advanced EGFR mutant non-small cell lung cancer (NSCLC). However, drug resistance is inevitable and outcomes with subsequent platinum-pemetrexed chemotherapy are poor. The role of immune-checkpoint inhibitor monotherapy in EGFR mutant NSCLC remains uncertain with trials demonstrating inferior survival outcomes compared to chemotherapy. However, a recent randomised study with combination checkpoint inhibitor-chemotherapy demonstrated improved survival over chemotherapy alone in this patient population. This study aims to evaluate the efficacy and tolerability of combination dual immune-checkpoint blockade, durvalumab and tremelimumab, with platinum-pemetrexed chemotherapy in metastatic EGFR mutant NSCLC following progression on EGFR-TKIs. Methods: This international phase II cohort study will recruit 100 participants from Australia and Taiwan with advanced EGFR mutant NSCLC following disease progression with EGFR-TKIs [Cohort 1 (n=50): T790M mutation negative on tissue and plasma; Cohort 2 (n=50): T790M mutation positive on tissue and/or plasma, and progression on3rd generation TKIs]. Participants will receive 4 cycles of induction durvalumab 1500mg and tremelimumab 75mg with platinum-pemetrexed chemotherapy every 3 weeks, followed by maintenance durvalumab 1500mg and pemetrexed 500mg/m2 every 4 weeks until disease progression. Response will be assessed at 6 and 12 weeks, then 8-weekly during the first year, and 12-weekly thereafter. Major endpoints include objective tumour response rate (OTRR; RECIST1.1; primary), disease control rate, OTRR (iRECIST), progression-free survival, overall survival, and adverse events. Correlative studies include biomarker assessment as potential predictive/prognostic factors. ILLUMINATE is a collaboration between the Australasian Lung Cancer Trials Group, National Health Research Institutes (Taiwan) and the NHMRC Clinical Trials Centre, University of Sydney. As of 6/2/2020, 11 of planned 100 participants have been recruited. Clinical trial information: NCT03994393 .
Randomized phase III study of first-line pembrolizumab plus pemetrexed/platinum followed by pembrolizumab and maintenance olaparib versus pemetrexed in patients with metastatic nonsquamous non-small cell lung cancer (NSCLC): KEYLYNK-006.
Authors: Gray Jhanelle Elaine , Owonikoko Taofeek Kunle , Kato Terufumi , Cardona Zorrilla Andres Felipe , Wagman Joanne , Chen Xinqun , Zhao Bin , Schulz Christian
Published: May 2020

TPS9632

Background: First-line treatment with pembrolizumab + pemetrexed/platinum improved clinical outcomes in patients with advanced nonsquamous NSCLC in KEYNOTE-021 and KEYNOTE-189. Poly(ADP-ribose) polymerase inhibitors (PARPi), including olaparib, have been shown to upregulate PD-L1 expression in preclinical studies, and preliminary evidence suggests potential therapeutic benefit and acceptable safety with PARPi plus anti–PD-(L)1 therapy. KEYLYNK-006 (NCT03976323) evaluates first-line pembrolizumab + pemetrexed/platinum followed by pembrolizumab + olaparib vs pembrolizumab + pemetrexed in patients with metastatic nonsquamous NSCLC. Methods: This phase III, randomized, open-label trial enrolls patients aged ≥18 years with histologically/cytologically confirmed treatment-naive, metastatic, nonsquamous NSCLC. Patients (target n = 792) receive induction pembrolizumab 200 mg + pemetrexed 500 mg/m2 + carboplatin AUC 5 mg/mL/min or cisplatin 75 mg/m2 Q3W for 4 cycles. Patients with PR/CR or SD are randomized (target n = 618) 1:1 to pembrolizumab 200 mg Q3W (31 cycles) + maintenance olaparib 300 mg twice daily or pembrolizumab + pemetrexed 500 mg/m2 Q3W stratified by ECOG PS (0 vs 1), PD-L1 tumor proportion score (<50% vs ≥50%), and response (CR/PR vs SD). Tumor imaging per RECIST version 1.1 (≤5 per organ; maximum 10 total lesions) by central review (BICR) is performed at baseline and Q6W until 60 weeks after randomization, then Q9W until disease progression, start of new cancer therapy, study withdrawal, or death. Primary endpoints are PFS (RECIST 1.1 by BICR) and OS estimated by the Kaplan-Meier method, stratified log-rank test, and Cox proportional hazard model with Efron’s method of tie handling. Secondary endpoints are safety and quality of life; ORR and duration of response are exploratory endpoints. AEs are monitored throughout the study until 30 days after the last dose of treatment (90 days for serious AEs) and graded using NCI CTCAE, version 4.0. The study began enrolling in June 2019. Clinical trial information: NCT03976323 .
Use of chlorine solutions as disinfectant agents in health units to contain the spread of COVID-19
Authors: Andrade Frank Pereira de , Pereira Camila de Bessa
Published: May 2020

Objective: This study aimed to gather information available in different disinfection protocols for establishments that provide care to suspected or confirmed patients with COVID-19, to contain the spread of the virus, besides proposing different ways of preparing the bleach solution for the most varied purposes within a Health Unit. Methods: It was realized bibliographic research about disinfection protocols to contain COVID-19, as well as disinfectant agents used to inactivate the virus. Results: Many hospitals and basic health units perform disinfection in many hospitals based on disinfection protocols that are not suitable due to the insufficient amount of daily cleaning recommended, as well as the use of ineffective agents or in inadequate concentrations. Among the most used disinfectant agents chlorine solutions have been described as the most efficient and most applicable, thus, we recommend the use of solutions containing chlorine in its composition, such as commercial bleach, as well as highlight its finalities, correct way of use and application at environments that take care of patients with disease COVID-19 or suspected. Conclusion: the use of solutions containing chlorine in its composition, such as commercial bleach, is a viable alternative for disinfecting hospitals and health basic units, due to its efficiency against the coronavirus, low cost, accessibility, and greater applicability when detected by other widespread disinfectant agents.
Forecasting of Change in Level of Personnel Reliability As a Factor of Increase of Personnel Safety of the Enterprise
Authors: Kiryuhina Ol'ga
Published: May 2020

The article is devoted to one of the threats to the organization's personnel security-the reliability of personnel. The paper considers approaches to determining the essence of personnel reliability and factors that influence it. Methodological tools of the research: economic and mathematical modeling. According to the study, the efficiency and readiness of employees to perform their job duties efficiently have a significant impact not only on the total duration of working time losses and, but also on the economic efficiency of the enterprise as a whole. Based on the research, in order to ensure protection from personnel failures and reduce possible downtime, the article offers a model for predicting personnel reliability. With the help of which you can assess the degree of reliability of personnel and predict cases of loss of working condition of personnel. The proposed model will allow you to develop appropriate management decisions and avoid personnel risks of the organization.
Crisis Management Strategy As a Competitive Advantage of an International Company
Authors: Repnikova Valentina , Shevaldova L.
Published: May 2020

The article discusses the role of crisis management strategy in ensuring the competitive advantage of an international company in a crisis that arose for objective reasons. The author analyzes average enterprises’ preparedness for crises and proposes key directions for elaborating a crisis management strategy for international companies. Also, the author proposes key ideas for developing a crisis management strategy in terms of pandemic and worldwide regulatory restrictions.
Supra-Industry Technologies in the Mechanism of Financing of Cultural Industries in Russia
Authors: Mal'shina N.
Published: May 2020

The main goal of this work is to develop effective forms of financing for cultural industries. Information and methodological elements were formed. ensuring the process of logistics of the cultural services system. As a result, there is an objective need for system monitoring of the database of cultural industry organizations and innovative use of modern information technologies in solving complex economic problems to justify optimal solutions with a variety of alternative options.According to the author's classification of cultural services into passive and active, it is possible to distinguish two ways in the development of basic technologies and in the cultural industry. Mechanisms of innovative interaction of cultural institutions with business and government structures can be divided into several types: project financing (support for certain projects); social innovation and investment (support coincides with certain business strategies); donation interaction with business on a philanthropic basis; investment exchanges for cultural, art and creative projects; service contract (life cycle contract); fundraising for scientific (educational) and cultural services; concessions in the cultural industry; business incubators as a multiplier-accelerator for the culture industry (support for the system of cultural services at an early stage) , etc. The development and application of cross-industry information and communication technologies gives the largest volume of production of cultural services with a low cost, due to the scale of production.
Assessment of Country Development Potentials in Innovation Activity Raitngs (Great Britain, China, Russia)
Authors: Danko Tamara , Garnova A.
Published: May 2020

This article analyzes the impact of innovation activity of countries (Great Britain, China and Russia). Accurate calculations are carried out with regard to the indicators of the rating positioning of these countries. It is expected to give a clear interpretation of the results obtained, to compare the trends in the indicators of Russia with the countries of Great Britain and China. The entry of national economies into the phase of globalization is characterized, in particular, by increased market activity and increased competition between all subjects of market relations. The basis of the latter is, first, leadership in innovation and the use of scientific, technical and technological developments to maintain a leading position.
Biological effects of amniotic membrane on diabetic foot wounds: a systematic review
Authors: Paggiaro André Oliveira , Menezes Andriws Garcia , Ferrassi Alexandra Donizetti , De Carvalho Viviane Fernandes , Gemperli Rolf
Published: May 2020

Objective:

The amniotic membrane has biological properties that are beneficial to the wound healing process of diabetic foot ulcers (DFU). Our aim is to analyse the scientific evidence found in literature on the use of the amniotic membrane to stimulate DFU healing.

Method:

A systematic review of amniotic membrane's influence was undertaken, using the search terms ‘placenta’ ‘diabetic foot’ ‘amnion’ and biological dressing’, assessing the outcomes ‘wound healing’ and ‘wound healing time’, in DFU. Following the inclusion and exclusion criteria, randomised controlled trials (RCT) were identified, and the risk of bias was analysed according to the Cochrane risk of bias tool. We conducted a meta-analysis of the two outcomes to evaluate the level of evidence.

Results:

We identified six clinical trials, with a total of 331 patients. The most common risks of bias in the studies were selection, attrition, and detection biases. From the meta-analysis, the difference of the intervention group (amnion) in relation to the control group was statistically significant. We found that wound healing in the group treated with amniotic membrane occurs 2.32 times more often and is 32 days faster in comparison with the group that used conventional dressings.

Conclusion:

There is statistical evidence to support the effectiveness of amniotic membrane in comparison with other conventional dressings. In addition, there is a clear tendency for the use of amniotic membrane treatment to result in a larger number of DFUs healing at a quicker rate.
Coming together under pressure: Network DES 2020
Authors: Cumberlege Justin
Published: May 2020

Justin Cumberlege, a partner in the healthcare law firm Hempsons, highlights some key points in the new Primary Care Network direct enhanced services contract
The role of nutrition in critical care
Authors: Latimer-Jones Kathryn
Published: May 2020

Critically ill patients have conditions that are considered life-threatening and require comprehensive care and constant monitoring; nutritional support plays a key role in the recovery of these patients and is an area of veterinary medicine that is very easy for the registered veterinary nurse (RVN) to have an active role in. Critically ill patients are at increased risk of malnutrition; acute and chronic illness, trauma and inflammation induced stress-related catabolism, and drug-induced adverse effects may reduce appetite or increase nausea and vomiting. Challenges exist in the provision of support, especially in the anorexic patient.

This article focuses on how severe physiological stress affects animals that are critically ill and how this might lead to malnutrition, how to accurately calculate energy requirements, and discusses the importance of selecting the most appropriate diet to improve patient outcomes.
PERSISTENCIA TEMPORAL DO ARMAZENAMENTO DE ÁGUA NO SOLO PARA DEFINIÇÃO DA REGIÃO DE MONITORAMENTO EM ÁREA IRRIGADA
Authors: Hara Anderson Takashi , Gonçalves Antônio Carlos Andrade , Santos Fernando André  Silva , Rezende Roberto , Domingues João Vitor da Silva
Published: May 2020

A lâmina de água armazenada no solo, em uma área vegetada, apresenta variação espaço-temporal, o que estabelece incertezas em relação à região a ser monitorada para fins de controle de irrigação. Tendo-se como premissa o fato de que o seu padrão espacial de distribuição é persistente no tempo, pode-se identificar a região que sistematicamente apresenta valores médios representativos de toda a área, empregando as análises de estabilidade temporal. Mas esta persistência temporal em uma região sempre está associada a uma variabilidade em torno da média geral, o que levou à proposição de um indicador da consistência temporal (ICT). Para o desenvolvimento do trabalho, cultivou-se Urochloa decumbens em uma área experimental, solo de textura muito argilosa, durante dois ciclos anuais. Em cada ciclo, foram feitas medidas da lâmina de água armazenada no solo (ARM),  durante ciclos de secamento do solo, e também do índice de área foliar (IAF) da cultura. O emprego de técnicas geoestatísticas, associadas à análise de estabilidade temporal foram realizadas. Os resultados evidenciam que é possível caracterizar o ICT como um indicador adequado e conveniente como suporte à tomada de decisão em questões referentes ao monitoramento de água no solo em sistemas agrícolas irrigados.
Construindo o Projeto Cuidadosamente: reflexão sobre a saúde mental dos graduandos de Enfermagem frente ao COVID-19
Authors: Rocha Natália Loureiro , Sora Alcilea Barbosa de Andrade , Lapa Alessandra da Terra , Dos Santos Daniele Durval
Published: May 2020

O presente relato de experiência visa destacar a vivência dos autores na construção do Projeto Cuidadosamente em uma universidade privada localizada no município do Rio de Janeiro. Objetiva-se com esse estudo apontar a sua inserção prática, bem como, retratar a importância de um projeto desta magnitude no cuidado à saúde psíquica dos acadêmicos de enfermagem, principalmente no contexto atual de isolamento social pela pandemia de COVID-19. Conclui-se que a ação possibilita a construção de uma rede de apoio entre os próprios colegas de classe que estão experenciando as mesmas dificuldades com esse isolamento social e ameniza situações que possam maximizar ou desencadear algum tipo de transtorno mental, a exemplo de ansiedade e depressão, através de uma escuta qualificada, que é atribuição importante do enfermeiro nos diferentes níveis de assistência. Building the Project Mindfully: reflection on the mental health of nursing students in front of COVID-19The present experience report aims to highlight the authors’ experience in the construction of the Project Mindfully in a private university located in the city of Rio de Janeiro. The objective of this study is to point out its practical insertion, as well as, to portray the importance of a project of this magnitude in the care of the psychic health of nursing students, especially in the current context of social isolation by the pandemic of COVID-19. It is concluded that the action makes it possible to build a support network among the classmates themselves who are experiencing the same difficulties with this social isolation and alleviates situations that can maximize or trigger some type of mental disorder, such as anxiety and depression, through qualified listening, which is an important role of nurses at different levels of care.
Les dones a les economies domèstiques preindustrials: treball, terra, dot i escreix a l’Alt Penedès del segle XVIII
Authors: Moreno Claverías Belén
Published: May 2020

En aquest article es fa una aproximació al paper de les dones en les economies domèstiques de l’Alt Penedès del segle XVIII. Concretament, s’analitzen les tasques productives que portaven a terme i que eren fonamentals per al manteniment de les famílies, les seves relacions amb la propietat i l’explotació de la terra, la importància que tenien el dot i l’escreix al llarg de la seva vida, i l’evolució del dot durant la segona meitat del segle XVIII. En cada una d’aquestes qüestions es fa menció de les dones solteres, casades i vídues, atèsque l’estat civil era la variable que més fortament condicionava el que les dones podien i no podien fer. També es para atenció, de manera transversal, al marc legal que constrenyia l’autonomia econòmica de les dones. Malgrat el silenci de les fonts, conseqüència directa de la baixa consideració que tenia el treball femení, del seu caràcter suposadament subsidiari i de la incapacitat legal a què les dones estaven sotmeses, l’examen de capítols matrimonials, inventaris post mortem, contractes de conreu i textos de testimonis de l’època, permet entreveure unes dones més actives i més autònomes que el que tradicionalments’acostuma a pensar. El marc cultural i legal, així com la pobresa, eren obstacles importants que calia superar.
Les tribulacions de les dones en la gestió del patrimoni familiar. El cas de Maria Muntaner i Ardèvol (1761-1835)
Authors: Sanmartí Roset Carme , Sanmartí Roset Montserrat
Published: May 2020

S’han fet nombrosos estudis sobre el rol rellevant dels hereus en el desenvolupament econòmic dels masos i el rol de les dones en la gestió de la llar i en l’educació dels fi lls i les filles, però no s’ha analitzat sufi cientment quins eren els reptes que tenien les dones quan es feien càrrec de l’explotació d’un mas. En una societat en què es prioritzaven els homes en la transmissió de l’herència i les fi lles eren vistes com la darrera solució, l’única situació en què les dones podien dirigir el seu propi patrimoni o gestionar el del marit en usdefruit, o totes dues coses alhora, era quan quedaven vídues i no es tornaven a casar. Aquest article es proposa analitzar el cas de Maria Muntaner i Ardèvol, de Porrera, una dona que hagué d’enfrontar-se des de ben petita a les difi cultats derivades de la seva condició d’òrfena, primer, de pubilla, després, i de vídua amb una fi lla, fi nalment. La seva fi gura permet estudiar les estratègies que va seguir per sobreviure a les diferents situacions vitals i preservar el seu patrimoni i el de la seva fi lla, i alhora ens facilita indagar en quins moments la seva condició de dona li va comportar difi cultats addicionals.
Els cultius i la distribució social de les terres entre els possessors de Reus i el seu terme a partir de les estimes dels anys 1445 i 1541
Authors: Morelló Baget Jordi
Published: May 2020

A partir de la comptabilització de les terres i altres béns rurals anotats en dos llibres d’estimes, es fa una radiografi a, en primer terme, de les diferents tipologies de conreus presents a l’antic terme de Reus entre les dues fi tes cronològiques referenciades. En segon lloc, s’analitza, també des d’un punt de vista comparatiu, la distribució de la riquesa rural entre la població vilatana i del terme. Els resultats obtinguts, malgrat que evidencien un quadre bastant continuista, serveixen per constatar certs canvis evolutius entre els segles XV i XVI, en consonància amb el desenvolupament socioeconòmic de la localitat en qüestió.
«A ro de 28 sous i mig oli mes, i mesureta»: els salaris de les collidores d’olives a Mallorca, 1645-1687
Authors: Jover-Avellà Gabriel , Pujadas-Mora Joana Maria
Published: May 2020

El propòsit d’aquest article és fer una contribució empírica a la reconstrucció dels salaris femenins en el sector agrícola en l’època preindustrial. Malgrat la complexitat que implica la confecció de les sèries salarials, particularment les femenines, és imprescindible continuar emprant-les i millorant-les per tal de copsar el funcionament social i econòmic de les societats agràries preindustrials. L’estudi se centra en l’illa de Mallorca al segle XVII, on s’havia desenvolupat una important especialització oleícola a partir de grans explotacions que exportaven els seus excedents al mercat internacional. Aquestes explotacions contractavenmà d’obra femenina i infantil per a la recollida de l’oliva. Aquesta mà d’obra femenina es convertí en un factor clau en la reproducció d’aquest sistema agrari. Per tant, el coneixement de l’evolució dels seus salaris constitueix un element cabdal per capir tant l’evolució dels costos d’explotació dels terratinents i arrendataris, com la importància dels salaris en els ingressos i nivells de vida de les famílies pageses.
Application of the generalized contrast-to-noise ratio to assess photoacoustic image quality
Authors: Kempski Kelley M. , Graham Michelle T. , Gubbi Mardava R. , Palmer Theron , Lediju Bell Muyinatu A.
Published: May 2020

The generalized contrast-to-noise ratio (gCNR) is a relatively new image quality metric designed to assess the probability of lesion detectability in ultrasound images. Although gCNR was initially demonstrated with ultrasound images, the metric is theoretically applicable to multiple types of medical images. In this paper, the applicability of gCNR to photoacoustic images is investigated. The gCNR was computed for both simulated and experimental photoacoustic images generated by amplitude-based (i.e., delay-and-sum) and coherence-based (i.e., short-lag spatial coherence) beamformers. These gCNR measurements were compared to three more traditional image quality metrics (i.e., contrast, contrast-to-noise ratio, and signal-to-noise ratio) applied to the same datasets. An increase in qualitative target visibility generally corresponded with increased gCNR. In addition, gCNR magnitude was more directly related to the separability of photoacoustic signals from their background, which degraded with the presence of limited bandwidth artifacts and increased levels of channel noise. At high gCNR values (i.e., 0.95-1), contrast, contrast-to-noise ratio, and signal-to-noise ratio varied by up to 23.7-56.2 dB, 2.0-3.4, and 26.5-7.6×1020, respectively, for simulated, experimental phantom, and in vivo data. Therefore, these traditional metrics can experience large variations when a target is fully detectable, and additional increases in these values would have no impact on photoacoustic target detectability. In addition, gCNR is robust to changes in traditional metrics introduced by applying a minimum threshold to image amplitudes. In tandem with other photoacoustic image quality metrics and with a defined range of 0 to 1, gCNR has promising potential to provide additional insight, particularly when designing new beamformers and image formation techniques and when reporting quantitative performance without an opportunity to qualitatively assess corresponding images (e.g., in text-only abstracts).
Lensless hyperspectral phase imaging in a self-reference setup based on Fourier transform spectroscopy and noise suppression
Authors: Shevkunov Igor , Katkovnik Vladimir , Egiazarian Karen
Published: May 2020

A novel phase retrieval algorithm for broadband hyperspectral phase imaging from noisy intensity observations is proposed. It utilizes advantages of the Fourier transform spectroscopy in the self-referencing optical setup and provides additional, beyond spectral intensity distribution, reconstruction of the investigated object’s phase. The noise amplification Fellgett’s disadvantage is relaxed by the application of a sparse wavefront noise filtering embedded in the proposed algorithm. The algorithm reliability is proved by simulation tests and by results of physical experiments for transparent objects. These tests demonstrate precise phase imaging and object depth (profile) reconstruction.
Average gradient of Zernike polynomials over polygons
Authors: Akondi Vyas , Dubra Alfredo
Published: May 2020

Wavefront estimation from slope sensor data is often achieved by fitting measured slopes with Zernike polynomial derivatives averaged over the sampling subapertures. Here we discuss how the calculation of these average derivatives can be reduced to one-dimensional integrals of the Zernike polynomials, rather than their derivatives, along the perimeter of each subaperture. We then use this result to derive closed-form expressions for the average Zernike polynomial derivatives over polygonal areas, only requiring evaluation of polynomials at the polygon vertices. Finally, these expressions are applied to simulated Shack-Hartmann wavefront sensors with 7 and 23 fully illuminated lenslets across a circular pupil, with their accuracy and calculation time compared against commonly used integration methods.
On-chip generation of the reconfigurable orbital angular momentum with high order
Authors: Liu Aiping , Wu Mengze , Zhuang Rui , Hong Jingjing , Wang Qin , Ren Xifeng
Published: May 2020

In this manuscript, the generation of an optical vortex beam with high order and reconfigurable orbital angular momentum (OAM) is studied. Multi-waveguide holographic gratings (MWHG) are deployed to generate OAM beams with high order. The generation of the OAM beam with an order l from +4 to +8 is demonstrated by numerical simulations, and the generated OAM order is manipulable and configurable by incident phase. The working bandwidths of the MWHG for different OAM orders are at the level of 40 nm. This work could provide valuable references for practical implementation of OAM in integrated optics.
Településfejlesztés, image vizsgálatok
Authors: Kis Mária
Published: May 2020

Produce of strategy of the territorial development precedences execution of some examinations whereby it comes to light that the judgement, different attitude of area of settlement. "We know the opinions and demands" - this declaration is frequent from management of settlements, because it isn't necessary thorough examinations. The expensive an time-consuming research confirmed the facts in many cases, while there indicated the motives and causes, possibilities of interventions and there Eire description from problems, opinions exactly and multilaterally.
Product management, controlling and logistics at agriculture and food manufacturing companies
Authors: Gál József , Kmoskó Éva
Published: May 2020

How to understand logistics in agro-food business? Logistic activities considerably changed in the last few years. The original aim of satisfying quantity needs has been followed by the logistic activity which meets the market's requirements, aims at satisfying the individual needs instead of standardized solutions, maximal the additional values, and finally, which gives a complex service. You can find special process of it in agriculture and food industry. These together mean a significant challenge for this profession. In our paper we try to understand methodology of logistics in agro-food business.
A fiskális transzparencia és a társadalmi elszámolási mátrix kiterjesztése
Authors: Czagány László
Published: May 2020

Enhancing transparency is a highly current and important task in improving public finances. In the most general sense, fiscal transparency means, that those economic actors which use data on the state and changes of the government budget to build their decisions on should be able to acquire these data in the appropriate quantity, quality and structure. One fundamental transparency-problem is the demarcation of macroeconomic actors viz. the sectors of the economy. This study aims at contributing to the solution of this problem by extending the social accounting matrix compiled in accordance with the guidelines of the ESA and SNA.
A "Szeged Regionális Hulladékgazdálkodási Program" ISPA projekt megvalósult beruházásainak üzemeltetési tapasztalatai
Authors: Szabó Ferenc , Keczer Gabriella
Published: May 2020

In my paper I analyze the operational experiences of the „Szeged Regional Waste Management Program" ISPA project. On the basis of the case study we can conclude, that the outcomes of engineering, PR and procurement projects turn to be trouble-free, but facilities implemented in the frame of constructional projects suffer several difficulties when operated. Thus, the operational problems are not necessary, but are the consequences of the tender procedures. The main reasons are the lack of professionalism, the consciously underestimated implementation costs on the side of the contractor, and the lack of cooperation between the main actors of the project.
Csapatépítés a HR-menedzser és a pszichológus szemszögéből
Authors: Gulyás László , Turcsányi Enikő
Published: May 2020

In this paper we study one part of team work's subject, and try to give the main viewspoints of selecting team members. One author of this paper is psychologist, the other one is HR-manager, both of them try to systematize the selections methods of team-members their point of view.
A gazdasági tanácsokkal kapcsolatos működési tapasztalatok az egyetemeken
Authors: Keczer Gabriella
Published: May 2020

A 2002-ben elindított felsőoktatási reform az egyetemi kormányzás rendszerének bevezetését tűzte ki célul a tradicionális egyetemirányítás felváltására, de részben az akadémiai szféra ellenállása, részben alkotmányossági problémák miatt a kezdeményezés kudarcba fulladt. Egyetlen eredménye az irányítás területén az úgynevezett gazdasági tanács intézményének létrehozása volt, igen szűk, tanácsadói hatáskörrel. Egy 10 egyetemvezetővel, 8 felsőoktatási intézményben lefolytatott mélyinteijú-sorozatból kiderül, hogy az intézmények felében a gazdasági tanácsok nem működnek megfelelően, és az egyetemvezetők többsége szerint nem alkalmasak arra, hogy az egyetemi kormányzás rendszerének megfelelően, nagyobb hatalommal bíró irányító testületekké alakuljanak.
E-közigazgatás és agrár-szakigazgatás Magyarországon
Authors: Nagy Elemérné , Hampel György , Fabulya Zoltán
Published: May 2020

The aim of our paper is to give an overview of the electronic public administration and the agrarian administration in Hungary. The size of the administration affects economic growth: it consumes 35 to 49 percent of the GDP in the European countries. By introducing electronic services, more than 5 percent of the administration costs can be saved. The efforts to digitize are based on the e-Europe programme with the objective to create an information society for everyone. After creating the legislative background in the past years, administration offices could digitize their registry and could start to offer more and more electronic services to the citizens and organizations. Although the level of digital literacy should be raised among the citizens and the civil servants as well, Hungary can be proud of the quality of the electronic administration services which is above the EU-28 average. The agrarian administration needs a lot of data which is collected and processed by information systems obligatory in the European Union. The collected data is required to effectively operate the agriculture and to access European agricultural subsidies. In the past few years efforts were made to catch up with the European agrarian information systems and today these systems are able to provide the necessary information for the administration and the farmers as well.
Fogyatékos személyek teljesítményértékelésének gyakorlata
Authors: Juhász Csilla
Published: May 2020

Performance management is one of the most important fields of management. For the evaluation of it, I have worked out a questionnary. With the help of the questionnaire I intended to ask about the importance and method of performance evaluation. Based on my examinations I found, that in managers opinions the best way to appraisal disabled person was the individual appraisial. This result is not a suprise, because of disabled persons. Because of the managers' practise there was a difference in opinions. But in theirs opinion the most important possibility was the individual appraisal too. It is nonsense to expect self appraisal from a mentally handicapped person. Examinations show that organizations mainly apply traditional systems and think by the traditional aspect.
Food quality during processing in logistic chain
Authors: Gál József
Published: May 2020

Quality of game is more and more important for customers. How can we supply customers with good quality meat? Logistics process of meet of wild animals is a special field of foodstuff. We use it for supply chains, buy and sell products, for information and our knowledge. I try to understand the logistic methodology for a special process. In agri-business sector we can speak, talk a lot about necessity of well organized networks, chains but there are not enough experts, workers organizing and doing this. You can find many parts of business activities using logistics at acceptable level and quality, but some area is not written in scientific style. In my paper I would like to speak about a very special segment of agri-business sector, which is game in logistics process. I mention some information about quality and food safety aspects of it.
Lagern und Transportieren von Fleisch
Authors: Nagy Elemérné , Schleusener Heinz , Sielaff Heinz
Published: May 2020

Für die Haltbarkeit und das Erhalten der Qualität von Produkten über eine gewisse Zeit sind bestimmte Kriterien wie das Einhalten der Hygieneanforderungen, der Temperatur während der Lagerung und im Falle des Befördern von Lebensmitteln die Beschaffenheit der Transportmittel von wesentlicher Bedeutung. Hierzu existieren Rechtsvorschriften für die Mitgliedsstaaten der Europäischen Union, die ebenso wie die genannten Kriterien in diesem Beitrag behandelt werden.
Egy kábeltelevíziós társaság vagyoni helyzetének vizsgálata (2003-2006) egy vidéki város, Mezőhegyes életében
Authors: Zsótér Brigitta , Gálné Horváth Ildikó , Szabóné Türkössy Anikó
Published: May 2020

Local Government of Mezőhegyes established Mezőhegyes Local TV Broadcasting Co. in 1997, which was sold out in 2004-ben for Bács-Kábel Ltd. How did his realization affect the company's financial situation? Onto the finding out of this we made it financial analysis onto the period 2003-2006 relevantly. Ali the balance, ail taking the figures of the resuit statement into considération though, Ltd. the décliné of the company's results was considérable after marketing him in 2004 year can be experienced.
Keeping the Learner at the Focal Point: The Use of Needs Assessment and Persona Construction to Develop an Instructional Resource Center For Instructional Designers
Authors: Stefaniak Jill , Shah Smruti , Mills Erin , Luo Tian
Published: May 2020

This design case shares how personas were utilized to create an online career resource center intended to help instructional design students in making informed career decisions. The outcome of this project has helped identify instructional opportunities to improve services currently provided to instructional design students and graduate student members of the Association for Education Communications and Technology (AECT ). By evaluating the mechanisms and supports already in place and contrasting those with the needs of the students who are seeking career guidance, the intent of the project was to bridge the gap between graduate student members’ career needs and the resources available to them within a professional association. We discuss how

we gathered information through a needs assessment for the creation of a Career Resource Center to further educate and inform instructional design students of resources for career decision-making.