bluuebunny/crossref_metadata_2025 huggingface dataset:
PERSPECTIVAS (TEÓRICO)-METODOLÓGICAS PARA O CAMPO DA PESQUISA EM EDUCAÇÃO AMBIENTAL: DILEMAS E AVANÇOS NO GDP METODOLOGIA
Authors: Sumi Kawasaki Clarice , Da Cunha Teixeira Marcos
Published: August 2018

Analisam-se as perspectivas teórico-metodológicas dos trabalhos apresentados nos Encontros de Pesquisa em Educação Ambiental (EPEA). Estas partem dos olhares e vivências dos coordenadores dos Grupos de Discussão em Pesquisa (GDP Metodologia) junto às discussões realizadas nesses grupos, cujos relatos encontram-se na forma de produções textuais, identificando-se os pontos limitantes e as potencialidades do campo metodológico da pesquisa em educação ambiental ao longo dos EPEAs.  Em meio à multirreferencialidade de perspectivas presentes nesses trabalhos, problemas de natureza epistemológico-metodológica são identificados, principalmente em função de uma forte tendência em atrelar as escolhas metodológicas dos investigadores a uma pesquisa voltada para a transformação social e às perspectivas críticas e metodologias participativas como as abordagens metodológicas que melhor responderiam a essa tendência. Os dilemas envolvidos e as implicações disso para as discussões teórico-metodológicas no campo da pesquisa em EA são discutidos, trazendo avanços para as discussões no GDP Metodologia. Para além dessas questões, uma pesquisa subversiva, em consonância com uma EA subversiva, se avizinha no horizonte, trazendo novas discussões para esse cenário.
Age-specific peripheral anti-müllerian hormone concentrations in goats (capra hircus)
Authors: Haldar Avijit , De Sachinandan , Singh Vinay , Datta Mrinmoy , Pal Prasenjit , Prakash Bukkaraya S.
Published: August 2018

Anti- Mullerian hormone (AMH) appears to be the best biochemical-endocrine marker in assessing the age-related decline of the ovarian follicular reserve. There is inadequate information on age-related changes in peripheral AMH concentrations in goats (Capra hircus). The present study thus aimed (i) to investigate the responsiveness of the ovary to gonadotrophin releasing hormone (GnRH) challenge to release plasma AMH into circulation in view of addressing the question whether ovarian secretion of AMH would be affected by gonadotrophic status in goats and (ii) to determine plasma AMH concentrations at different ages in goats (n= 82) using enzyme immune-assay technique. Data on hormonal concentrations in GnRH-treated animals as well as in different ages of animals were analyzed by nonparametric one-way repeated measure ANOVA and one-way ANOVA, respectively. There was no change (P greater than 0.05) of plasma AMH concentrations after GnRH challenge in experimental goats. Plasma AMH concentrations changed significantly (P less than 0.05) between the mean rank of the related groups over the time (age) in goats. Plasma AMH concentration at 3 months of age was 0.36 ± 0.04 ng/ ml and thereafter it started increasing and reached³ 2 ng/ ml between 3 and 4 years of age and then showed a progressive decline from 5 years of age and reached at 0.30 ± 0.07 ng/ ml at 10 years of age. A cubic model was found to be the best fitted model that delineated the change of plasma AMH level with age. Hence, the present study indicated that peripheral AMH concentration could be a useful management tool for the selection of goats in breeding programmes.
Screening of cattle gut associated Bacillus strains for their potential use as animal probiotic
Authors: Naeem M. , Ahmed I. , Ahmed S. , Ahmed Z. , Riaz M. N. , Ghazanfar S.
Published: August 2018

Use of antibiotic in animal feed pose a significant risk to human health. Over the last decade uses of probiotics increasingly viewed as an alternative to antibiotic. Bacillus are currently being used as feed supplements in animal diet, due to their enhanced tolerance rate and survivability under harsh gut environment. Animal gut is a rich source for Bacillus species isolation. There is still a scarcity of information on the Bacillus species of livestock species. The present study was carried out to identify Bacillus species from animal gut to evaluate their probiotic potential. Three (NCCP-2004a, NCCP-2029 and NCCP-2029) strains were selected as putative probiotics strains based on their super acid and bile survival rates. These isolates were identified as Bacillus subtilis subsp. inaquosorum (NCCP-2029, NCCP-2025). Bacillus tequilensis (NCCP-2004a) by 16S rRNA gene sequencing. NCCP-2004a elicited best results regarding antimicrobial potential and its ability to survive on acid and bile conditions. The results of present study demonstrated that the B. tequilensis showed a promising alternative probiotic candidate to the use of antibiotics in the dairy feeding system.
Exogenous gibberellic acid does not induce early flowering in mungbeans [Vigna radiata (L.) Wilczek.]
Authors: Raina Susheel Kumar , Yadav Punam Singh , Singh Ajay Kumar , Raskar Nikhil , Rane Jagadish , Minhas Paramjit Singh
Published: August 2018

Gibberellic acid (GA) is an important phyto-hormone mediating plant growth. In present study, we evaluated the impact of GA treatment on morphological, phenological and molecular aspects of five mungbean genotypes. GA treatment caused a significant increase in plant height and branch angle in most of the genotypes. However, there was no impact of GA treatment on days to first anthesis, days to 50% flowering and pod length. Genotypes SML-859 and EC-48 revealed no change in their plant height and branch angle respectively upon GA treatment, suggestive of their probable GA insensitivity. Expression of flowering associated gene- VrSOC1 remained unaffected by GA treatment, validating thereby that exogenously supplied GA does not induce early flowering in mungbeans.
Breeding groundnut for rust resistance: A review
Authors: Daudi Happy , Shimelis Hussein , Mwadzingeni Learnmore , Laing Mark , Okori Patrick
Published: August 2018

Sustainable groundnut production can be realised through development and adoption of high yielding cultivars possessing durable rust resistance. Integrating conventional breeding with genomic tools in identifying candidate rust resistance genes, and introgressing the genes into adapted elite germplasm, with the aid of molecular makers, could enhance breeding for rust resistance. This review highlights breeding approaches for groundnut rust resistance, with emphasis on integrating conventional breeding with marker-assisted selection. The life cycle, symptoms and epidemiology of the pathogen are also discussed to understand the host-pathogen interaction and guide groundnut rust resistance breeding
Learning the hidden structure of speech: from communicative functions to prosody
Authors: Bailly Gérard , Holm Bleike
Published: August 2018

Este artigo introduz um novo método, orientado via modelamento e via interação com dados comportamentais, para gerar padrões prosódicos a partir de informação metalingüística. Referimos aqui à habilidade geral da entoação de demarcar unidades de fala e veicular informação sobre as funções proposicional e interacional dessas unidades no discurso. Nossas hipóteses fortes são que (1) essas funções são diretamente implementadas como contornos prosódicos prototípicos que são co-extensivos às unidades para as quais eles se aplicam, (2) o padrão prosódico da mensagem é obtido ao superpor e adicionar todos os contornos elementares (Aubergé & Bailly, 1995). Descrevemos aqui um esquema de análise por síntese que consiste em identificar esses contornos prototípicos e separar suas contribuições respectivas nos contornos prosódicos dos dados de treinamento. O esquema é aplicado a bases de dados designadas para evidenciar várias funções entoacionais. Resultados experimentais mostram que o modelo gera contornos prosódicos adequados com pouquíssimos movimentos prototípicos.
 Anatomy, Age and Origin of an Intramontane Top Basin Surface (Sorbas Basin, Betic Cordillera, SE Spain)
Authors: Stokes Martin , Mather Anne E. , Rodés Ángel , Kearsey Samantha H. , Lewin Shaun
Published: August 2018

Collisional mountain belts commonly develop intramontane basins from mechanical and isostatic subsidence during orogenic development. These frequently display a relict top surface, evidencing a change interval from basin infilling to erosion often via capture or overspill. Such surfaces provide markers that inform on orogenic growth patterns via climate and base level interplay. Here, we describe the top surface from the Sorbas Basin, a key intramontane basin within the Betic Cordillera (SE Spain). The surface is fragmentary comprising high elevation hilltops and discontinuous ridges developed onto the variably deformed final basin infill outcrop (Gochar Formation). We reconstruct surface configuration using DEM interpolation and apply 10Be/26Al cosmonuclides to assess surface formation timing. The surface is a degraded Early Pleistocene erosional pediment developed via autogenic switching of alluvial fan streams under stable dryland climate and base level conditions. Base level lowering since the Middle Pleistocene focused headwards incision up interfan drainages, culminating in fan head capture and fan morphological preservation within the abandoned surface. Post abandonment erosion has lowered the basin surface by 31 m (average) and removed ~5.95 km3 of fill. Regional basin comparisons reveal a phase of Early Pleistocene surface formation, marking landscape stability following the most recent Pliocene-Early Pleistocene mountain building. Post-surface erosion rate quantification is low and in accordance with 10Be denudation rates typical of the low uplift Betic Cordillera.
Dimensional Analysis in Power Predicting of a Real Scale Wind Turbine Based on Wind Tunnel Torque Measurement of Small Scaled Models
Authors: Sutrisno Sutrisno , Iswahyudi Sigit , Wibowo Setyawan
Published: August 2018

A preliminary study of a wind turbine design is carried out using a wind tunnel to obtain its aerodynamic characteristics. Utilization of data from the study to develop large-scale wind turbines requires further study. This paper aims to discuss the use of wind turbine data obtained from the wind tunnel measurements to estimate the characteristics of wind turbines that have field size. The torque of two small-scale turbines was measured inside the wind tunnel. The first small-scale turbine has a radius of 0.14 m and the second small turbine has a radius of 0.19 m. Torque measurement results from both turbines were analyzed using Buckingham π theorem to obtain a correlation between torsion and diameter variations. The obtained correlation equation is used to estimate the field measurement of turbine power with a radius of 1.2 m. The resulting correlation equation can be used to estimate the power generated by the turbine by the size of the field well in the operating area of the tip speed ratio of the turbine design.
Voltage Control for DC-DC Converters
Authors: Rahat Usman , Basit Abdul , Salman Muhammad
Published: August 2018

In this paper, we discuss voltage control method for buck converter operating in continuous conduction mode (CCM) using analog feedback system. The aim of this work is to control the output voltage of a buck converter during the variation in load current. This is obtained using analog feedback made with operational amplifier (Opamp). However, the same technique can be applied to other DC-DC converters (e.g boost, buck-boost, cuk converter, etc) in CCM mode, but for the purpose of analysis buck converter is chosen as an example.
Palliative Care for Children with Central Nervous System Malignancies
Authors: Baenziger Peter , Moody Karen
Published: August 2018

Children with central nervous system (CNS) malignancies often suffer from high symptom burden and risk of death. Pediatric palliative care is a medical specialty, provided by an interdisciplinary team, which focuses on enhancing quality of life and minimizing suffering for children with life-threatening or life-limiting disease, and their families. Primary palliative care skills which include basic symptom management, facilitation of goals-of-care discussions, and transition to hospice can and should be developed by all providers of neuro-oncology care. This chapter will review the fundamentals of providing primary palliative care
Estimation of Salinity Intrusion by Using Landsat 8 OLI Data in The Mekong Delta, Vietnam
Authors: Tran Phuong Ha , Nguyen Anh Kim , Liou Yuei-An , Hoang Phung Phi , Nguyen Hung Thanh
Published: August 2018

Salinity intrusion is one of the most serious consequences of climate change coupled with rising sea level that significantly affects agricultural activities in many parts of the world. This phenomenon has increasingly become more serious and frequently occurred in the Mekong Delta of Vietnam. As a result, Vietnam has been ranked among top five countries where have been devastatingly impacted by climate change, in particular, its Tra Vinh Province characterized by coastal plain and alluvial deposit. In addition, this area is of the tropical monsoon zone of long rainy season with source of salt brought from the sea by the tides and sea level rise. Regions that are contaminated by salt are located in lowland and often suffer from floods linking to tidal effects with salty water from river systems and channels. Soil salinity evaluation is critical for coastal protection, restoration, and agricultural planning since it can be considered as an agricultural indicator to evaluate quality of soil. Here, we attempt to estimate the soil salinity in Tra Vinh Province, in the Mekong Delta of Vietnam. Landsat 8 OLI images are utilized to derive indices for soil salinity evaluation including single bands, Vegetation Soil Salinity Index (VSSI), Soil Adjusted Vegetation Index (SAVI), Normalized Difference Vegetation Index (NDVI), and Normalized Difference Salinity Index (NDSI). Subsequently, satistical analysis between soil salinity, electrical conductivity (EC, dS/m), and environmental indices derived from Landsat 8 OLI image is performed. Results indicate that spectral value of Near Infrared (NIR) band and VSSI are highly correlated with EC (R2 = 0.7779 and R2 = 0.6957, respectively) in comparison with the other indices. Comparative results show that soil salinity derived from Landsat 8 is consistent with in situ data. Findings of this study demonstrate that Landsat 8 OLI images reveal a high potential for spatiotemporally monitoring the magnitude of soil salinity at the top soil layer. Outcomes of this study are useful for agricultural activities, planners, and farmers by providing the base map of soil salinity contamination for better selection of accomodating crop types to reduce economical lost in the context of climate change. Our proposed method that estimates soil salinity using satellite-derived variables can be applied in the other regions.
Modelling, Parameters Identification and Experimental Validation of a Lead Acid Battery Bank Using Genetic Algorithms
Authors: Ariza Chacón Helbert Eduardo , Banguero Edison , Correcher Antonio , Pérez-Navarro Ángel , Morant Francisco
Published: August 2018

Accurate and efficient battery modeling is essential to maximize the performance of isolated energy systems and to extend battery lifetime. This paper proposes a battery model that represents the charging and discharging process of a lead-acid battery bank. This model is validated over real measures taken from a battery bank installed in a research center placed at “El Chocó”, Colombia. In order to fit the model, three optimization algorithms (Particle Swarm Optimization, Cuckoo Search, and Particle Swarm Optimization+Perturbation) are implemented and compared, being the last one a new proposal. This research shows that the model with the proposed algorithm is able to estimate and manage the real battery characteristics as SOC and charging/discharging voltage. The comparison between simulations and real measures shows that the model is able to absorb reading problems, signal delays, and scaling errors. The approach we present can be implemented in other types of batteries especially those used in stand-alone systems.
FLOW UNITS DETERMINATION USING FLOW ZONE INDICATOR FOR CARBONATE RESERVOIR
Authors: Haris Abdul , Riyanto Agus , Harsanto Tri Aji Adi , Rachmanto Ambar , Sukmatiawa Adang
Published: August 2018

In the last few years, the use of flow unit technique in the oil and gas industry has shown a great deal of success. Porosity and permeability from wire-line log and special core data analysis (SCAL) along with its cementation exponent value were integrated to characterize the reservoir in terms of pore volume caused by facies changing. In this work, we determine flow unit of the carbonate reservoir, which is applied to the Northwest Java Basin Field, Indonesia by performing the flow unit analysis, which allows approximating absolute permeability. Furthermore, the quantity and the flow unit of the reservoir rock is also determined to identify the secondary porosity. To reduce the level of uncertainty, wire-line logs data were validated with core data before it is used to interpret the reservoir. Subsequently, the result can be extrapolated to un-cored wells. Our experiment shows that flow units can be determined reliably from the integration between porosity and permeability, which have defined two different rock types in term of flow unit zone. The correlation of the flow units between wells leads to the definition of reservoir quality.
ANALISIS SIFAT OPTIK KLOROFIL PADA EKSTRAK DAUN MENGGUNAKAN UV-VIS SPEKTROMETER SEBAGAI STUDI AWAL APLIKASI DYE SENSITIZER
Authors: Dianisya Dona , Silmina Amalia Dini , Purwanto Novan , Isnaeni Isnaeni , Sugihartono Iwan
Published: August 2018

ABSTRAK

Telah dilakukan studi ekstraksi awal klorofil dari 3 jenis daun yaitu daun bayam (Amarantus), daun pepaya (Carica papaya), dan daun jarak (Ricinus communis). Ekstraksi dilakukan dengan teknik penghancuran menggunakan blender. Pelarut yang digunakan adalah isopropanol, asam asetat, dan DI water. Hasil penyaringan ekstrak daun diperoleh larutan sebayak 75 ml untuk setiap larutan ekstrak klorofil. Uji Ultrasonic Visible memberikan konfirmasi adanya penyerapan di rentang cahaya ultraviolet dan cahaya tampak. Sementara itu, serapan klorofil teramati di rentang cahaya tampak. Apabila dibandingkan serapan UV dan cahaya tampak, pada larutan ekstrak masih mengandung banyak gugus asam dibandingkan klorofil yang di ekstrak.

Kata-kata kunci: daun bayam, daun pepaya, daun jarak, absorbansi, klorofil

ABSTRACT

We studied for chlorophyll extract from 3 leaf types that are spinach leaf (Amarantus), papaya leaf (Carica papaya), and castor leaf (Ricinus communis). The extraction is done by using a blender. The solvents used are isopropanol, acetic acid, and DI water. The result of leaf extract was obtained 75 ml solution for each solution of chlorophyll extract. The Visible Ultrasonic Test confirms absorption in the range of ultraviolet light and visible light. Meanwhile, chlorophyll uptake is observed in the visible light spectrum. When compared to UV absorption and visible light, in the extract solution still contains a lot of acid groups than the chlorophyll extracted.

Keywords: spinach leaf, papaya leaf, Castor leaf, absorbance, chlorophyll.
ANALOG COMPUTER FOR STUDYING DIATOMIC MOLECULAR SPECTRA IN TERAHERTZ FREQUENCY
Authors: Malik Usman , Hamdi Muhamad , Salomo Salomo
Published: August 2018

This paper introduces a harmonic oscillator model for rovibronic terahertz spectrum of a model of a rigid diatomic rotor with some control parameters. The model shows a study of rotationally-resolved terahertz band spectra of the vibrational transition in diatomic molecules. THz radiation absorption is used as a closed-form system known as the analog computer dynamics mode. The optical terahertz region spectrum of the diatomic molecule consists of a series of lines. Their separations are not exactly constant. A diatomic molecule is not truly a rigid rotator, because it simultaneously vibrates with a small amplitude. Due to quantized vibrational and rotational energy levels and the selection rules, allowed transitions result in a highly ordered spectrum consisting of a P branch separated by a central gap. Adjacent spectral lines are separated by a spacing of 2B, and since line intensities depend on Boltzmann factor for thermal population and quantum number J, each branch monotonically increases and decreases. As temperature increases, more lines are observed, and line intensities decrease due to the population being spread over more rotational levels. Interactivity research also involves on effects of the fundamental vibrational frequency, rotational constant B and temperature included line width on the observed spectrum.
A Study on Student Loan Schemes in India and Australia
Authors: P. Sangeetha , Raghurama A.
Published: August 2018

Higher education or tertiary education has been perceived as an important sector which contributes to the economic progress among the countries of the world. Higher education has grown rapidly, at the same time the cost of higher education is also rising throughout the world. Education loan or student loan schemes, as one of the sources of financing higher education, have been introduced in most of the countries. This paper attempts to understand and compare the student loan schemes introduced and implemented in India and Australia either through the commercial banks or through the government. The study concludes that the student loan procedures followed in other countries can also be considered with suitable modifications for the improvement of our education loan scheme at present.
A desapropriação como instituto de proteção ao patrimônio cultural e análise da legislação aplicável
Authors: Cunha Filho Francisco Humberto , Saldanha Bianca de Souza
Published: August 2018

O Patrimônio Cultural e os institutos que viabilizam a sua proteção têm como arcabouço fundamental os artigos 215 e 216 da Constituição Federal de 1988. O instituto da desapropriação emerge, nesse contexto, como instrumento consolidado de intervenção supressiva na propriedade privada, que, motivado pela supremacia do interesse público sobre o privado e pela função social da propriedade, efetiva a proteção ao patrimônio cultural. Na presente pesquisa, analisam-se as leis que concretizam a desapropriação por valor cultural (o Decreto-Lei nº 3.365/41, a Lei nº 4.132/62, o Decreto-Lei nº 25/37 e a Lei nº 10.257/01) e a Arguição de Descumprimento de Preceito Fundamental – ADPF nº 206, ajuizada pelo Ministério Público Federal, que provoca o Supremo Tribunal Federal – STF acerca da interpretação do Decreto-Lei nº 3.365/41. Apresenta-se reflexão sobre a suficiência e a efetividade da legislação administrativa vigente no tocante à tutela dos bens concebidos como patrimônio cultural e suas especificidades intrínsecas.
Escolha do árbitro na terminação de conflitos administrativos: limites e possibilidades da atuação de um advogado público
Authors: Das Neves Cleuler Barbosa , Ferreira Filho Marcílio da Silva
Published: August 2018

Este artigo tem por assunto uma análise dos delineamentos jurídicos quanto à escolha de árbitro em procedimento arbitral que apresente em um dos polos da controvérsia a Administração Pública. Como problemática específica, pretende-se analisar os limites e as possibilidades da atuação de um advogado público na arbitragem envolvendo a Administração Pública, indagando sobre a possibilidade de sua nomeação como árbitro em face dos princípios da autonomia privada e da imparcialidade. O objetivo do estudo é analisar a viabilidade da criação de Câmaras arbitrais compostas por advogados públicos (procuradores dos Municípios, dos Estados, da União etc.), que não representem o ente estatal especificamente naquela lide. O tema apresenta relevância, na medida em que o sistema multiportas apresentado pela nova processualística vem sendo adaptado à utilização pela administração pública, porém sua viabilização ainda enfrenta problemas específicos, que merecem um devido aprofundamento.
O tribunal de contas no Brasil e seus congêneres europeus: um estudo comparativo
Authors: Carvalho Fábio Lins de Lessa , Rodrigues Ricardo Schneider
Published: August 2018

Neste trabalho, o modelo de Tribunal de Contas adotado no Brasil, a partir da Constituição de 1988, é comparado com seus congêneres europeus, em especial aqueles que influenciaram a sua criação em nosso país. Para tal fim, são apresentadas algumas noções relacionadas ao Direito Comparado e apresentado um estudo abrangendo os Tribunais de Contas do Brasil, da França, da Itália, da Espanha, além de diversas outras Instituições Superiores de Controle (ISC) da União Europeia, a partir de pesquisa bibliográfica qualitativa e documental, valendo-se, para tanto, do método informativo ou descritivo. O Brasil segue atualmente um modelo mais próximo do Francês, de Tribunal que delibera de forma colegiada, com função jurisdicional, sem vínculo com qualquer dos três Poderes, cujos membros têm status equivalente ao dos integrantes do Poder Judiciário e que exerce auditoria ex postdas espécies judicial, financeira e de performance. O diferencial mais claro entre a instituição brasileira e os modelos estudados consiste no tratamento marcadamente constitucional conferido pelo constituinte brasileiro, além da ampliação do seu espectro de atuação em razão da adoção do novo parâmetro de controle de legitimidade.
Brazil’s distinct brand of religious liberty: an example to the world, not without its challenges
Authors: Alton Alexander Curtis
Published: August 2018

Brazilian scholars, politicians, legal practitioners, and judges consistently refer to Brazil as a lay state, suggesting a type of secularism similar to French laïcité. However, in practice, the interaction between government, religion, and society in Brazil more closely resembles religious freedom in the United States. Among the twenty-six most populous countries, Brazil has the lowest governmental restrictions on religious freedom. The Brazilian government protects religious liberty through extensive constitutional and statutory provisions, as well as numerous international conventions. Notwithstanding these governmental protections, the country has recently experienced a dramatic increase in social hostilities directed toward people of faith. Thus, while Brazil is an example to the world with regard to minimal governmental restrictions on religious liberty, both the government and Brazilian citizens must find ways to minimize social hostilities and religious intolerance. This paper compares religious liberty in Brazil to French laïcité and U.S. religious freedom, explores governmental protections of religion in Brazil, exposes the growth of social hostilities towards religious groups in Brazil, highlights the work of government and grassroots organizations to turn back this rising tide of religious intolerance, and offers several suggestions on how the Brazilian government might further decrease social hostilities.
A EXPRESSIVIDADE DA DANÇA CIRCULAR BUSCA HOSPITALIDADE, ACOLHIMENTO E AMOROSIDADE NAS RELAÇÕES
Authors: Ávila Newton , Baptista Maria Luiza Cardinale
Published: August 2018

Esta pesquisa propõe a dança circular, como expressão de vínculos de acolhimento e amorosidade, em condições de oferecer sinalizadores para a hospitalidade. Tem como objetivos específicos: apresentar a dança circular num contexto relacional entre os sujeitos; relacionar os conceitos de acolhimento e amorosidade à dança circular; identificar sinalizadores de hospitalidade, nos vínculos marcados pelo acolhimento e amorosidade, em decorrência da dança circular. A Cartografia de Saberes, proposta por Baptista, é a orientação metodológica para a produção deste estudo, com realização das trilhas de saberes pessoais, saberes teóricos e a usina de produção. Foram realizadas aproximações investigativas, com levantamento bibliográfico, desenvolvimento de intervenções de dança em diversos ambientes e observação do corpo participante. Nas ações práticas, observação direta, observação participante, rodas de conversa, relatos de vivências e experimentação com desenvolvimento da dança circular. Os resultados indicaram que o desenvolvimento da dança circular, proporcionou, aos sujeitos participantes, sensação de bem-estar, laços de proximidade, acolhimento e amorosidade. Concluiu-se que a dança circular é uma forma de integrar o corpo e sua expressividade, em situação de comunicação e expressão. É capaz de acionar o pensamento e explorar a criatividade, estabelecendo troca com o ‘outro’. Proporciona sensação de pertencimento e provoca soltura nos corpos, relaxamento e relação-convívio.
HOSPITALIDADE E FESTA DO ESPÍRITO SANTO: CONTRIBUTOS DA CARIDADE, MISERICÓRDIA E COMENSALIDADE
Authors: Gastal Susana de Araujo , MARTINS CRISTIANE MESQUITA GOMES
Published: August 2018

O presente artigo, de teor ensaístico, tem como objeto a Festa do Divino Espírito Santo, comemorada em Portugal e outros países, entre eles o Brasil, onde a presença de imigrantes portugueses tenha sido significativa. Independente do local de comemoração, a Festa marca-se pela hospitalidade expressa na comensalidade, que parece ter na caridade e na misericórdia sua sustentação em termos de imaginário. Para percorrer tal percurso de construção de sentido, opta-se por retomar a história da festividade em Portugal e as marcas comuns da comemoração que emergem dos seus desdobramentos temporais, quais sejam, as figuras da caridade (bodo) e da misericórdia, que tecem amálgamas na comensalidade. Retomam-se, no primeiro momento, as raízes etimológicas dos termos caridade e misericórdia para, a seguir, buscar sua presença histórica na Festa. A análise parece encaminhar, considerando a Festa do Divino Espírito Santo como comemorada em Alcântara, Maranhão, que os mesmos indicadores estarão, em termos mais recentes, associados à hospitalidade religiosa.
Molecular Design of Peptide-Fc Fusion Drugs
Authors: Ning Lin , He Bifang , Zhou Peng , Derda Ratmir , Huang Jian
Published: August 2018

Background:

Peptide-Fc fusion drugs, also known as peptibodies, are a category of biological therapeutics in which the Fc region of an antibody is genetically fused to a peptide of interest. However, to develop such kind of drugs is laborious and expensive. Rational design is urgently needed.

Methods:

We summarized the key steps in peptide-Fc fusion technology and stressed the main computational resources, tools, and methods that had been used in the rational design of peptide-Fc fusion drugs. We also raised open questions about the computer-aided molecular design of peptide-Fc.

Results:

The design of peptibody consists of four steps. First, identify peptide leads from native ligands, biopanning, and computational design or prediction. Second, select the proper Fc region from different classes or subclasses of immunoglobulin. Third, fuse the peptide leads and Fc together properly. At last, evaluate the immunogenicity of the constructs. At each step, there are quite a few useful resources and computational tools.

Conclusion:

Reviewing the molecular design of peptibody will certainly help make the transition from peptide leads to drugs on the market quicker and cheaper.
Long-Term Safety and Efficacy of Bapineuzumab in Patients with Mild-to-Moderate Alzheimer’s Disease: A Phase 2, Open-Label Extension Study
Authors: Salloway Stephen , Marshall Gad A. , Lu Ming , Brashear H. Robert
Published: August 2018

Background:

Bapineuzumab is a humanized anti-amyloid-beta (Aβ) monoclonal antibody
directed at lowering the cerebral Aβ deposit in Alzheimer’s disease (AD).

Objective:

This phase 2, open-label extension (OLE) study evaluated long-term safety and efficacy of
bapineuzumab in patients with the mild-to-moderate AD.

Methods:

Patients (58-78 years) who completed either of two randomized, placebo-controlled, doubleblind
studies (subcutaneous [SC] single-dose-escalation, or intravenous (IV) multiple-ascending-dose))
entered the OLE. Three groups were assessed: bapineuzumab or placebo SC, and bapineuzumab (IV) in
OLE (bapi SC/bapi IV); bapineuzumab (IV) in Study 201 and OLE (bapi/bapi); and placebo in Study
201 and bapineuzumab IV in OLE (placebo/bapi).

Results:

Of 194 patients enrolled, 158 withdrew from OLE; primarily due to withdrawal by subject
(n=85) and AE (n=30). Mean (SD) bapineuzumab exposure was 2.9 (1.90) years. There were no significant
differences for efficacy endpoints (AD Assessment Scale–cognitive subscale [ADAS-Cog], Disability
Assessment for Dementia [DAD] and MMSE scores) between the bapi/bapi and placebo/bapi
groups. Most patients (94.8%, 184/194) reported ≥1 treatment-emergent adverse events (TEAEs) in
OLE. Amyloid-related imaging abnormalities with effusion or edema (ARIA-E) occurred in 22 (11.3%)
patients. The most common TEAEs (>20% patients) were fall, agitation and urinary tract infection with
similar incidences between bapi/bapi and placebo/bapi groups.

Conclusion:

No significant difference was seen in cognitive and functional decline between early and
delayed treatment groups. No new safety concerns emerged. ARIA-E incidence was higher in patients
first exposed to bapineuzumab in OLE versus previously exposed. No clear pattern of etiology contributed
to death events.
A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis
Authors: Branco Jessica R. , Oliveira Vanessa G. , Esteves Amanda M. , Chipoline Ingrid C. , Lima Miriam F.O. , Boechat Fernanda C.S. , da Silva Fernando C. , Ferreira Vítor F. , Sola-Penna Mauro , de Souza Maria C.B.V. , Zancan Patricia
Published: August 2018

Background:

Breast cancer is a major cause of death among women worldwide. Treatment
for breast cancer involves the surgical removal of cancer tissue, followed by chemotherapy. Although
the treatment is efficient, especially when the cancer is detected early, recurrence is common and is often
resistant to the previous treatment. Therefore, a constant search for efficient and novel drugs for the
treatment of breast cancer is mandatory. Recently, triazole derivatives have shown promising effects
against different types of cancer, revealing these molecules as putative anticancer drugs.

Experimental:

We have synthesized a series of naphthotriazolyl-4-oxoquinoline derivatives and tested
their activity against a human breast cancer cell line. Among the compounds tested, we identified a
molecule that killed the human breast cancer cell line MCF-7 with minimal effects on its noncancer
counterpart, MCF10A. This effect was seen after 24 hours of treatment and persisted for additional 24
hours after treatment withdrawal. After 1 hour of treatment, the compound, here named 12c, promoted a
decrease in cell glucose consumption and lactate production. Moreover, the cells treated with 12c for 1
hour showed diminished intracellular ATP levels with unaltered mitochondrial potential and increased
reactive oxygen species production. Additionally, apoptosis was triggered after treatment with the drug
for 1 hour. All of these effects are only observed with MCF-7 cells, and not MCF10A. These data show
that 12c has selective activity against breast cancer cells and is a potential candidate for a novel anticancer
drug.

Results and Conclusion:

The naphthotriazolyl-4-oxoquinoline derivatives were obtained in good to
moderate yields, and one of them, 12c, exhibited strong and selective antitumor properties. The antitumor
mechanism involves inhibition of glycolysis, diminished intracellular ATP levels, induction of ROS
production and triggering of apoptosis. These effects are all selective for cancer cells, since noncancer
cells are unaffected, and these effects can only be attributed to the whole molecule, as different pharmacophoric
groups did not reproduce these effects.
Efficacy and Safety of Targeting Androgen Receptor in Advanced Breast Cancer: A Systematic Review
Authors: Kassem Loay , Shohdy Kyrillus S. , Makady Nafie F. , Salem Dalal S. , Ebrahim Nadia , Eldaly Mostafa
Published: August 2018

Background::

Androgen receptor (AR) upstreams complex signaling pathways that regulate cell proliferation and contribute to breast tumorignensis. Several clinical trials were initiated to investigate the clinical relevance of targeting AR especially in hormone-receptor-negative breast cancer.

Methods::

The search was performed in PubMed and the meeting libraries of ASCO, ESMO, SABCS, ImpakT congresses from January 2005 to July 2017. The following key words were used: Breast cancer, Androgen receptor, androgen agonist/antagonist, Flutamide, Abiraterone, Bicalutamide, Enzalutamide, Enobosarm, selective androgen receptor modulator.

Results::

Screening of title/abstracts yielded a total of 20 relevant results. Of those, twelve studies were found eligible: eleven clinical trials along with one case report. Response rates ranged from 0 to 12% while clinical benefit rates reached up to 35% in 2 studies (with enzalutamide and enobosarm). Progression-free survival ranged from 2.8 to 4.5 months. The most widely used cutoff for AR expression was 10%. High expression of AR was associated with more clinical benefit. Regarding safety, anti-androgens were generally well tolerated with hot flushes, elevated transaminases and fatigue being the most commonly reported across all agents.

Conclusion::

Androgen receptor pathway targeting in advanced breast cancer remains a valid option with reasonable clinical benefit in non-selected patients. Future studies are needed to define an AR addicted cohort with better responses and outcome.
Phytochemical Investigation, Acute Toxicity, Central Analgesic and Antioxidant Activities of Extracts and Essential Oil of Cotula cinerea Del (Asteraceae)
Authors: Guaouguaou Fatima E. , Bebaha Mohamed A.A. , Taghzouti Khalid , Es-Safi Nour E.
Published: August 2018

Background:

Cotula cinerea belongs to the Asteraceae family and grows in desert areas such as Moroccan Sahara. The use of this plant in Moroccan traditional medicine prompted us to investigate its chemical composition, its acute oral toxicity, its analgesic and antioxidative activities.

Methods:

Extraction was conducted by steam distillation for essential oil and by maceration using solvents (hexane, ethyl acetate, n-butanol) for other non-volatile compounds. Quantitative analysis of total polyphenols, procyanidins and flavonoids was conducted through spectrophotometric assays. Qualitative phytochemical composition of the essential oil was investigated by GC/MS analysis. Acute oral toxicity was tested at a dose of 2000 mg/kg in mice. Central analgesic effect was assessed in rat using tail flick and hot plate models and the obtained results were compared to morphine. Antioxidant activity of the essential oil and the obtained extracts was evaluated through 2,2-diphenyl-1- picrylhydrazyl (DPPH°) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and the obtained results were compared to TROLOX.

Results:

The obtained results showed that the studied extracts contained significant amounts of total polyphenols, flavonoids and condensed tannins. The phytochemical composition of the essential oil was predominated by thujone, eucalyptol and santolinatriene. The results of the acute oral toxicity showed that the tested essential oil and extracts were not toxic even at the highest dose of 2000 mg/kg. Experiments on analgesic activity showed that the administered extracts have a central analgesic effect. The highest effect was observed with the n-butanol and ethyl acetate extracts for both tail-flick and hot plate tests. The antioxidant activity of the explored extracts showed higher scavenging activities of the studied samples compared to TROLOX.

Conclusion:

Our results indicate thus that C. cinerea could be considered as a source of various secondary metabolites including terpenoids and polyphenols. Exploration of its biological activities showed that the plant essential oil and extracts possessed antioxidant and analgesic effects. Based on the results of this study, it is likely that extracts of C. cinerea could open perspectives for its use for pain relief.
Modulation of Cancer Metabolism by Phytochemicals - A Brief Overview
Authors: Muntean Danina M. , Sturza Adrian , Pavel Ioana Z. , Duicu Oana M.
Published: August 2018

Despite tremendous research efforts for effective therapies, cancer remains the plague of the century
and its burden is expected to increase worldwide in the near future. Metabolic reprogramming is a firmly established
hallmark of all cancers, regardless of their cellular or tissue origin, being a prerequisite for both tumor
growth and invasion. Functional dependence of tumors on glycolysis and glutaminolysis and the crucial contribution
of mitochondria to the tumor bioenergetic versatility are well recognized features and established therapeutic
targets. The complex landscape of tumor metabolism in the context of the dynamic, bidirectional crosstalk
with its stromal environment is a rapidly evolving field that increasingly supports the view of cancer both as
metabolic disease and a disease of impaired cellular 'communication'. Many of the approved anticancer drugs
are derived from natural sources and the search of novel drug candidates is still a priority view the rapid development
of chemoresistance. Phytochemicals are biologically active plant compounds with preventive and/or
curative anticancer properties able to potentiate the effects of standard therapies while decreasing their toxicity
via multitarget modulatory effects. The present mini-review will briefly summarize the hallmarks of metabolic
reprogramming in tumor cells and the phytochemicals that have been reported to modulate the dysregulated
metabolism of tumor and its environment, with special emphasis on triterpenes.
Wastewater Collection Systems
Authors: Vallabhaneni Srinivas
Published: August 2018

This chapter presents a review of the literature published in 2017 on topics relating to wastewater collection systems. It presents noteworthy advances in research and industry experiences selected from major literature sources. This review is divided into the following sections: sewer system planning; asset management/ condition assessment/ sewer rehabilitation; pump stations/ force mains/ system design; operations/ maintenance/ optimization/ intelligent sewer platforms; tunnel systems; and regulatory issues/ integrated planning.
Disinfection Processes
Authors: Kuo Jeff
Published: August 2018

A review of the literature published in 2017 on topics relating to disinfection processes is presented. This review is divided into the following sections: disinfection methods, disinfection byproducts (DBPs), microbiology and microbial communities, and distribution network and biofilm.
Food‐Processing Wastes
Authors: Frenkel Val S. , Cummings Gregg A. , Maillacheruvu K.Y. , Tang Walter Z.
Published: August 2018

Literature published in 2017 and early 2018 related to food processing wastes treatment for industrial applications are reviewed. This review is a subsection of the Treatment Systems section of the annual Water Environment Federation literature review and covers the following food processing industries and applications: general, meat and poultry, fruits and vegetables, dairy and beverage, and miscellaneous treatment of food wastes.
Power Production Waste
Authors: Ye Junpei , Wang Siqi , Zhang Panyue , Nabi Mohammad , Wang Hongjie
Published: August 2018

This paper reviewed the research literatures published in 2017 about power production waste generated from fuel and nuclear power plants. The treatment, reuse, management and disposal of power production waste were mainly considered. The wastes from different power plants mainly include fly ash, flue gas desulfurization gypsum and waste selective catalytic reduction catalyst, and so on. The monitoring, management, treatment and disposal of power production waste were also reviewed.
Emerging Pollutants–Part I: Occurrence, Fate and Transport
Authors: Zhao Yanting , Ye Lin , Zhang Xu‐Xiang
Published: August 2018

The presence of emerging pollutants (EPs) in water poses a potentially new and serious challenge on human health. Here, we reviewed the relevant literatures published in 2017, summarized the occurrence, environmental fate, transport and impacts of EPs in the environment, and analyzed the environmental toxicity of personal care products (PPCPs), endocrine disrupting chemicals (EDCs), antibiotics and antibiotic resistance genes (ARGs), nanoparticles (NPs) and nanomaterials (NMs). This — review mainly focused on the occurrence surveys on surface water and the associations between exposure to EPs and toxicity of testing organisms. The control strategies and regulation for EPs based on the screening and monitoring methods were also discussed. Future efforts should be made to establish a comprehensive framework to study the adverse effects of EPs on organisms and new policies and legislations should be developed to control the release of hazardous EPs to the environment.
Analytical Methods for Pesticides and Herbicides
Authors: Liu Chuan , Guo Bing , Xue Jinkai
Published: August 2018

A review of the literatures published in 2017 on topics relating to analytical methods for pesticides and herbicides is presented in this paper. Based on different techniques, this review is divided into seven parts, i. e., extraction methods, chromatographic or mass spectrometric techniques, electrochemical techniques, spectrophotometric techniques, chemiluminescence and fluorescence methods, biochemical assays and immunoassays, and miscellaneous techniques.
Membrane Processes
Authors: Pellegrin Marie‐Laure , Aguinaldo Jorge , Arabi Sara , Sadler Mary E. , Greiner Anthony D. , Wong Joseph , Dow Andrew , Burbano Marie S. , Danker Bryce , Diamond Jason
Published: August 2018

This review, for literature published in 2017, contains information related to membrane processes for municipal and industrial applications. This review is a subsection of the Treatment Systems section of the annual Water Environment Federation literature review and covers the following topics: membrane bioreactor (MBR) configuration, design, nutrient removal, operation, industrial treatment, anaerobic membrane systems, reuse, microconstituents removal, membrane technology advances, membrane fouling, and modeling. Other sub‐sections of the Treatment Systems section that might relate to this literature review include: Biological Fixed‐Film Systems, Activated Sludge and Other Aerobic Suspended Culture Processes, Anaerobic Processes, and Water Reclamation and Reuse. The following sections might also have related information on membrane processes: Industrial Wastes, Hazardous Wastes, and Fate and Effects of Pollutants.
Gaseous Emissions from Wastewater Facilities
Authors: Koh Sock‐Hoon , Shaw Andrew R.
Published: August 2018

A review of the literature published in 2017 on topics relating to gaseous emissions from wastewater facilities is presented. This review is divided into the following sections: odorant emissions from wastewater treatment plants (WWTPs); greenhouse gas (GHG) emissions from WWTPs; gaseous emissions from wastewater collection systems; physiochemical odor/emissions control methods; biological odor/emissions control methods; odor/GHG characterization/monitoring/ modeling; and odor impacts/risk assessments.
Water Reclamation and Reuse
Authors: Sun Huijuan , Zhang Huixin , Xu Rui , Zou Xin , Liu Yang
Published: August 2018

Literature published in 2017 related to water reclamation and reuse is reviewed in four categories: sustainable reuse, treatment technology, implementation, and assessment and management. The development and improvement of conventional treatments and new methods that afford safe wastewater reuse are examined.
Sustainability
Authors: DiGiovanni Kimberly
Published: August 2018

This review on Sustainability covers selected 2017 publications on the focus of Sustainability. It is divided into the following sections: • Water quantity • Water quality • Climate change and resilience • Planning and ecosystem evaluation