bluuebunny/crossref_metadata_2025 huggingface dataset:
Analgesic Effect of 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one in Experimental Animal Models of Nociception
Authors: Kamarudin Nadhirah , Hisamuddin Nadia , Ong Hui Ming , Ahmad Azmi Ahmad Farhan , Leong Sze Wei , Abas Faridah , Sulaiman Mohd Roslan , Shaik Mossadeq Wan Mastura
Published: August 2018

Curcuminoids derived from turmeric rhizome have been reported to exhibit antinociceptive, antioxidant and anti-inflammatory activities. We evaluated the peripheral and central antinociceptive activities of 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), a novel synthetic curcuminoid analogue at 0.1, 0.3, 1 and 3 mg/kg (intraperitoneal), through chemical and thermal models of nociception. The effects of DHHPD on the vanilloid and glutamatergic systems were evaluated through the capsaicin- and glutamate-induced paw licking tests. Results showed that DHHPD significantly (p < 0.05) attenuated the writhing response produced by the 0.8% acetic acid injection. In addition, 1 and 3 mg/kg of DHHPD significantly (p < 0.05) reduced the licking time spent by each mouse in both phases of the 2.5% formalin test and increased the response latency of mice on the hot-plate. However, the effect produced in the latter was not reversed by naloxone, a non-selective opioid receptor antagonist. Despite this, DHHPD decreased the licking latency of mice in the capsaicin- and glutamate-induced paw licking tests in a dose response manner. In conclusion, DHHPD showed excellent peripheral and central antinociceptive activities possibly by attenuation of the synthesis and/or release of pro-inflammatory mediators in addition to modulation of the vanilloid and glutamatergic systems without an apparent effect on the opioidergic system.
Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa
Authors: Demine Stéphane , Balhuizen Alexander , Debaille Vinciane , Joosten Lieke , Fereau Maïté , Chilla Satya Narayana Murthy , Millard Isabelle , Scharfmann Raphaël , Egrise Dominique , Goldman Serge , Marchetti Piero , Gotthardt Martin , Laurent Sophie , Burtea Carmen , Eizirik Decio L.
Published: August 2018

Non-invasive imaging and quantification of human beta cell mass remains a major challenge. We performed pre-clinical in vivo validation of a peptide previously discovered by our group, namely, P88 that targets a beta cell specific biomarker, FXYD2γa. We conjugated P88 with DOTA and then complexed it with GdCl3 to obtain the MRI (magnetic resonance imaging) contrast agent (CA) Gd-DOTA-P88. A scrambled peptide was used as a negative control CA, namely Gd-DOTA-Scramble. The CAs were injected in immunodeficient mice implanted with EndoC-βH1 cells, a human beta cell line that expresses FXYD2γa similarly to primary human beta cells. The xenograft-bearing mice were analyzed by MRI. At the end, the mice were euthanized and the CA biodistribution was evaluated on the excised tissues by measuring the Gd concentration with inductively coupled plasma mass spectrometry (ICP-MS). The MRI and biodistribution studies indicated that Gd-DOTA-P88 accumulates in EndoC-βH1 xenografts above the level observed in the background tissue, and that its uptake is significantly higher than that observed for Gd-DOTA-Scramble. In addition, the Gd-DOTA-P88 showed good xenograft-to-muscle and xenograft-to-liver uptake ratios, two potential sites of human islets transplantation. The CA shows good potential for future use to non-invasively image implanted human beta cells.
Raspberry Polyphenolic Extract Regulates Obesogenic Signals in Hepatocytes
Authors: Fotschki Bartosz , Laparra José , Sójka Michał
Published: August 2018

The aim of this in vitro study was to examine the effect of raspberry polyphenolic extract on the immune-metabolic molecular mechanisms activated by obesity-related signals in hepatocytes (HB-8965®). Alterations in endosomal/lysosomal activity (neutral red uptake assay, NR), the expression of selected genes involved with lipid oxidation, and metabolism and inflammation processes in the liver were studied. Hepatocytes were treated with plasma collected from Wistar rats that were fed a high-fat diet (HF), raspberry polyphenolic extract (PP), serine-type protease inhibitors as an agonist of TLR4 (TD) or a combination of PP with HF or TD treatments. The PP added to the experimental treatments modulated hepatic immune-metabolic mechanisms through the upregulation of STAT1, ANGPTL4, and CD44, as well as considerably reducing the NR uptake and downregulation of COX-2 and the multifunctional protein AhR. The kinetic analysis of AhR expression revealed that HF-related molecular mechanisms activated AhR mRNA expression earlier than PP initiated the regulatory effect. In conclusion, PP might be considered a valuable dietary agent that regulates obesity-related signals in hepatocytes. Moreover, taking AhR kinetic behavior into consideration, it can be assumed that PP might modulate the severity of the HF-induced downstream metabolic signaling of AhR.
Tailoring Blue-Green Double Emissions in Carbon Quantum Dots via Co-Doping Engineering by Competition Mechanism between Chlorine-Related States and Conjugated π-Domains
Authors: Sun Xue , Liu Huilian , Yang Lili , Wang Xinying , Yang Weiqiang , Wei Maobin , Liu Xiaoyan , Cao Jian , Yang Jinghai , Xing Scott Guozhong
Published: August 2018

Representing single-layer to tens of layers of graphene in a size less than 30 nm, carbon quantum dots (CQDs) is becoming an advanced multifunctional material for its unique optical, electronic, spin and photoelectric properties induced by the quantum confinement effect and edge effect. In present work, upon co-doping engineering, nitrogen and chlorine co-doped CQDs with uniquely strong blue-green double emissions are developed via a facile and one-pot hydrothermal method. The crystalline and optical properties of CQDs have been well manipulated by tuning the mole ratio of nitrogen/chlorine and the reaction time. The characteristic green emission centered at 512 nm has been verified, originating from the chlorine-related states, the other blue emissions centered at 460 nm are attributed to the conjugated π-domain. Increasing the proportion of 1,2,4-benzentriamine dihydrochloride can effectively adjust the bandgap of CQDs, mainly caused by the synergy and competition of chlorine-related states and the conjugated π-domain. Prolonging the reaction time promotes more nitrogen and chlorine dopants incorporate into CQDs, which inhibits the growth of CQDs to reduce the average size of CQDs down to 1.5 nm, so that the quantum confinement effect dominates into play. This work not only provides a candidate with excellent optical properties for heteroatoms-doped carbon materials but also benefits to stimulate the intensive studies for co-doped carbon with chlorine as one of new dopants paradigm.
Mesoporous Graphitic Carbon Nitrides Decorated with Cu Nanoparticles: Efficient Photocatalysts for Degradation of Tartrazine Yellow Dye
Authors: Zhang Tao , Souza Isis P. A. F. , Xu Jiahe , Almeida Vitor C. , Asefa Tewodros
Published: August 2018

A series of mesoporous graphitic carbon nitride (mpg-C3N4) materials are synthesized by directly pyrolyzing melamine containing many embedded silica nanoparticles templates, and then etching the silica templates from the carbonized products. The mass ratio of melamine-to-silica templates and the size of the silica nanoparticles are found to dictate whether or not mpg-C3N4 with large surface area and high porosity form. The surfaces of the mpg-C3N4 materials are then decorated with copper (Cu) nanoparticles, resulting in Cu-decorated mpg-C3N4 composite materials that show excellent photocatalytic activity for degradation of tartrazine yellow dye. The materials’ excellent photocatalytic performance is attributed to their high surface area and the synergistic effects created in them by mpg-C3N4 and Cu nanoparticles, including the Cu nanoparticles’ greater ability to separate photogenerated charge carriers from mpg-C3N4.
Synthesis of Nanofibrillated Cellulose by Combined Ammonium Persulphate Treatment with Ultrasound and Mechanical Processing
Authors: Filipova Inese , Fridrihsone Velta , Cabulis Ugis , Berzins Agris
Published: August 2018

Ammonium persulfate has been known as an agent for obtaining nanocellulose in recent years, however most research has focused on producing cellulose nanocrystals. A lack of research about combined ammonium persulfate oxidation and common mechanical treatment in order to obtain cellulose nanofibrils has been identified. The objective of this research was to obtain and investigate carboxylated cellulose nanofibrils produced by ammonium persulfate oxidation combined with ultrasonic and mechanical treatment. Light microscopy, atomic force microscopy (AFM), powder X-Ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and Zeta potential measurements were applied during this research. The carboxylated cellulose suspension of different fractions including nanofibrils, microfibrils and bundles were produced from bleached birch Kraft pulp fibers using chemical pretreatment with ammonium persulfate solution and further defibrillation using consequent mechanical treatment in a high shear laboratory mixer and ultrasonication. The characteristics of the obtained nanofibrils were: diameter 20–300 nm, crystallinity index 74.3%, Zeta potential −26.9 ± 1.8 mV, clear FTIR peak at 1740 cm−1 indicating the C=O stretching vibrations, and lower thermostability in comparison to the Kraft pulp was observed. The proposed method can be used to produce cellulose nanofibrils with defined crystallinity.
Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children
Authors: De Medeiros Pedro Henrique Q. S. , Pinto Daniel V. , De Almeida Juliana Zani , Rêgo Juliana M. C. , Rodrigues Francisco A. P. , Lima Aldo Ângelo M. , Bolick David T. , Guerrant Richard L. , Oriá Reinaldo B.
Published: August 2018

The micronutrient vitamin A refers to a group of compounds with pleiotropic effects on human health. These molecules can modulate biological functions, including development, vision, and regulation of the intestinal barrier. The consequences of vitamin A deficiency and supplementation in children from developing countries have been explored for several years. These children live in an environment that is highly contaminated by enteropathogens, which can, in turn, influence vitamin A status. Vitamin A has been described to modulate gene expression, differentiation and function of diverse immune cells; however, the underlying mechanisms are not fully elucidated. This review aims to summarize the most updated advances on elucidating the vitamin A effects targeting intestinal immune and barrier functions, which may help in further understanding the burdens of malnutrition and enteric infections in children. Specifically, by covering both clinical and in vivo/in vitro data, we describe the effects of vitamin A related to gut immune tolerance/homeostasis, intestinal barrier integrity, and responses to enteropathogens in the context of the environmental enteric dysfunction. Some of the gaps in the literature that require further research are also highlighted.
The Effect of Digestion and Digestibility on Allergenicity of Food
Authors: Pali-Schöll Isabella , Untersmayr Eva , Klems Martina , Jensen-Jarolim Erika
Published: August 2018

Food allergy prevalence numbers are still on the rise. Apart from environmental influences, dietary habits, food availability and life-style factors, medication could also play a role. For immune tolerance of food, several contributing factors ensure that dietary compounds are immunologically ignored and serve only as source for energy and nutrient supply. Functional digestion along the gastrointestinal tract is essential for the molecular breakdown and a prerequisite for appropriate uptake in the intestine. Digestion and digestibility of carbohydrates and proteins thus critically affect the risk of food allergy development. In this review, we highlight the influence of amylases, gastric acid- and trypsin-inhibitors, as well as of food processing in the context of food allergenicity.
Bioavailability of Vitamin B12 from Dairy Products Using a Pig Model
Authors: Bueno Dalto Danyel , Audet Isabelle , Girard Christiane L. , Matte Jean-Jacques
Published: August 2018

The present study compares the bioavailability of vitamin B12 (B12) of dairy products or synthetic B12, using the pig as an experimental model for humans. Eleven pigs were used in a cross-over design to assess the net portal drained viscera (PDV) flux of blood plasma B12 after ingestion of tofu (TF; devoid of B12), Swiss cheese (SC), Cheddar cheese (CC), yogurt (YG), and synthetic B12 (TB12; TF supplemented with cyanocobalamin), providing a total of 25 µg of B12 each. PDV blood plasma flow for SC and CC were higher than for TF and TB12 (p ≤ 0.04) whereas YG was higher than TF (p = 0.05). Porto-arterial difference of blood plasma B12 concentrations were higher for CC and TB12 than for TF and YG (p ≤ 0.04) but not different from SC (p ≥ 0.15). Net PDV flux of B12 was only different from zero for CC. However, the net PDV flux of B12 for CC was not different from SC or TB12. Cumulative net PDV flux of B12 for SC, TB12, and CC were 2.9, 4.4, and 8.3 µg 23 h post-meal, corresponding to a bioavailability of 11.6%, 17.5%, and 33.0%, respectively. In conclusion, CC had the best bioavailability of B12 among the tested dairy products or compared to synthetic B12.
The Role of Choice in Weight Loss Strategies: A Systematic Review and Meta-Analysis
Authors: Leavy Jill M. , Clifton Peter M. , Keogh Jennifer B.
Published: August 2018

Effective strategies to achieve weight loss and long-term weight loss maintenance have proved to be elusive. This systematic review and meta-analysis aims to explore whether the choice of weight loss strategy is associated with greater weight loss. An electronic search was conducted using the MEDLINE (Medical Literature Analysis and Retrieval System Online, or MEDLARS Online), EMBASE (Excerpta Medica database), CINAHL (Cumulative Index to Nursing and Allied Health Literature), and PsycINFO (Database of Abstracts of Literature in the Field of Psychology, produced by the American Psychological Association and distributed on the association’s APA PsycNET) databases for clinical trials and randomized controlled trials, investigating the role of choice in weight loss strategies. A total of nine studies were identified as meeting the pre-specified criteria. All of the studies included a ‘Choice’ or preference arm and a ‘No Choice’ arm or group who did not receive their preference as a control. A total of 1804 subjects were enrolled in these studies, with weight loss observed in both experimental and control groups of all studies, irrespective of dietary intervention, study duration, or follow-up length. Twelve interventions in nine trials were used for the meta-analysis, with results indicating a greater weight loss in the control groups, 1.09 ± 0.28 (overall mean difference in weight loss between groups ± standard error; p = 0). There was no significant effect of duration or attrition. In this meta-analysis, the choice of weight loss strategy did not confer a weight loss benefit.
Biological Active Ecuadorian Mango ‘Tommy Atkins’ Ingredients—An Opportunity to Reduce Agrowaste
Authors: Ruales Jenny , Baenas Nieves , Moreno Diego A. , Stinco Carla M. , Meléndez-Martínez Antonio J. , García-Ruiz Almudena
Published: August 2018

Mango is a commercially important tropical fruit. During its processing, peel and seed kernel are discarded as waste but they could be recovered as an excellent and cost-effective source of health-promoting ingredients. This study aimed to characterize some of them, including carotenoids like the provitamin A β-carotene and lutein, with an interest beyond its role in eye health. Other health-promoting compounds like tocopherols and polyphenols were also evaluated, as well as the in vitro antioxidant capacity of mango by-products. Regarding isoprenoids, α-tocopherol was mainly found in the peels and carotenoids concentration was higher in the pulps. β-carotene was the most abundant carotene in pulp and seed kernel, whereas peel was the only source of lutein, with violaxanthin the most abundant xanthophyll in the different mango organs tested. With regard to polyphenols, peels exhibited greater variability in its phenolic composition, being the total content up to 85 and 10 times higher than the pulp and seed kernels, respectively. On the other hand, peels also stood out for being a very rich source of mangiferin. Seed kernels and peels showed higher antioxidant capacity values than the pulps. These results contribute to the valorization of mango by-products as new natural ingredients for the pharma and food industries.
Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability
Authors: Gigliobianco Maria Rosa , Casadidio Cristina , Censi Roberta , Di Martino Piera
Published: August 2018

Many approaches have been developed over time to overcome the bioavailability limitations of poorly soluble drugs. With the advances in nanotechnology in recent decades, science and industry have been approaching this issue through the formulation of drugs as nanocrystals, which consist of “pure drugs and a minimum of surface active agents required for stabilization”. They are defined as “carrier-free submicron colloidal drug delivery systems with a mean particle size in the nanometer range, typically between 10–800 nm”. The primary importance of these nanoparticles was the reduction of particle size to nanoscale dimensions, with an increase in the particle surface area in contact with the dissolution medium, and thus in bioavailability. This approach has been proven successful, as demonstrated by the number of such drug products on the market. Nonetheless, despite the definition that indicates nanocrystals as a “carrier-free” system, surface active agents are necessary to prevent colloidal particles aggregation and thus improve stability. In addition, in more recent years, nanocrystal properties and technologies have attracted the interest of researchers as a means to obtain colloidal particles with modified biological properties, and thus their interest is now also addressed to modify the drug delivery and targeting. The present work provides an overview of the achievements in improving the bioavailability of poorly soluble drugs according to their administration route, describes the methods developed to overcome physicochemical and stability-related problems, and in particular reviews different stabilizers and surface agents that are able to modify the drug delivery and targeting.
A Qualitative Study Exploring the Role of Pharmacists in Medical Student Training for the Prescribing Safety Assessment
Authors: Al-Kudhairi Fay , Kayyali Reem , Savickas Vilius , Sharma Neel
Published: August 2018

Five years after the introduction of the Prescribing Safety Assessment (PSA) in the UK, the role pharmacists play to help prepare medical students for this challenge is uncertain. Our study explored pharmacists’ perceptions about their role in undergraduate medical training for the Prescribing Safety Assessment (PSA). One hundred and seventy-nine prospective participants from UK hospitals and education and training boards were emailed an interview schedule aimed at ascertaining their current involvement in undergraduate medical education, particularly the preparation for PSA. Responses received via email were thematically-analysed. A total of 27 hospital pharmacists and 3 pharmacists from local education and training boards participated in the interviews. Pharmacists were positive about their involvement in medical student training, recognising the added value they could provide in prescribing practice. However, respondents expressed concerns regarding resource availability and the need for formal educational practice mentoring. Despite a low response rate (17%), this research highlights the potential value of pharmacists’ input into medical education and the need for a discussion on strategies to expand this role to maximise the benefits from having a pharmacist skill mix when teaching safe prescribing.
Pharmacy Practice and Education in Croatia
Authors: Končić Marijana Zovko , Atkinson Jeffrey
Published: August 2018

The PHARMINE (“Pharmacy Education in Europe”) project examined the organisation of pharmacy practice and education in the European Union (EU). An electronic survey was sent out to community, hospital, and industrial pharmacists, and university staff and students. This paper presents the results of the PHARMINE survey for Croatia. We examined to what extent harmonisation with EU norms has occurred, whether this has promoted mobility, and what impact it has had on healthcare.
Improving Flexibility and Energy Efficiency of Post-Combustion CO2 Capture Plants Using Economic Model Predictive Control
Authors: Decardi-Nelson Benjamin , Liu Su , Liu Jinfeng
Published: August 2018

To reduce CO 2 emissions from power plants, electricity companies have diversified their generation sources. Fossil fuels, however, still remain an integral energy generation source as they are more reliable compared to the renewable energy sources. This diversification as well as changing electricity demand could hinder effective economical operation of an amine-based post-combustion CO 2 capture (PCC) plant attached to the power plant to reduce CO 2 emissions. This is as a result of large fluctuations in the flue gas flow rate and unavailability of steam from the power plant. To tackle this problem, efficient control algorithms are necessary. In this work, tracking and economic model predictive controllers are applied to a PCC plant and their economic performance is compared under different scenarios. The results show that economic model predictive control has a potential to improve the economic performance and energy efficiency of the amine-based PCC process up to 6% and 7%, respectively, over conventional model predictive control.
The Ritualizing of the Martial and Benevolent Side of Ravana in Two Annual Rituals at the Sri Devram Maha Viharaya in Pannipitiya, Sri Lanka
Authors: De Koning Deborah
Published: August 2018

Within the context of Ravanisation—by which I mean the current revitalisation of Ravana among Sinhalese Buddhists in Sri Lanka—multiple conceptualizations of Ravana are constructed. This article concentrates on two different Ravana conceptualizations: Ravana as a warrior king and Ravana as a healer. At the Sri Devram Maha Viharaya, a recently constructed Buddhist complex in Colombo, Ravana has become the object of devotion. In addition to erecting a Ravana statue in a shrine of his own, two annual rituals for Ravana are organized by this temple. In these rituals we can clearly discern the two previously mentioned conceptualizations: the Ravana perahera (procession) mainly concentrates on Ravana’s martial side by exalting Ravana as warrior king, and in the maha Ravana nanumura mangalyaya, a ritual which focusses on healing, his benevolent side as a healer is stressed. These conceptualizations from the broader Ravana discourse are ritualized in iconography, attributes, and sacred substances. The focus on ritual invention in this article not only directs our attention to the creativity within the rituals but also to the wider context of these developments: the glorification of an ancient civilization as part of increased nationalistic sentiments and an increased assertiveness among the Sinhalese Buddhist majority in post-war Sri Lanka.
Framework for Mapping Integrated Crop-Livestock Systems in Mato Grosso, Brazil
Authors: Manabe Víctor Danilo , Melo Marcio R. S. , Rocha Jansle Vieira
Published: August 2018

Integrated crop-livestock (ICL) systems combine livestock and crop production in the same area, increasing the efficiency of land use and machinery, while mitigating greenhouse gas emissions, and reducing production risks, plant diseases and pests. ICL systems are primarily divided into annual (ICLa) and multi-annual (ICLm) systems. Projects such as the “Integrated crop-livestock-forest Network” and the “Livestock Rally” have estimated the ICL areas for Brazil on a state or regional basis. However, it remains necessary to create methods for spatial identification of ICL areas. Thus, we developed a framework for mapping ICL areas in Mato Grosso, Brazil using the Enhanced Vegetation Index time-series of Moderate Resolution Imaging Spectroradiometer and a Time-Weighted Dynamic Time Warping (TWDTW) classification method. The classification of ICL areas occurred in three phases. Phase 1 corresponded to the classification of land use from 2008 to 2016. In Phase 2, the ICLa areas were identified. Finally, Phase 3 corresponded to the ICLm identification. The framework showed overall accuracies of 86% and 92% for ICL areas. ICLm accounted for 87% of the ICL areas. Considering only agricultural areas or only pasture areas, ICL systems represented 5% and 15%, respectively.
Contribution of Land Surface Temperature (TCI) to Vegetation Health Index: A Comparative Study Using Clear Sky and All-Weather Climate Data Records
Authors: Bento Virgílio A. , Trigo Isabel F. , Gouveia Célia M. , DaCamara Carlos C.
Published: August 2018

The Vegetation Health Index (VHI) is widely used for monitoring drought using satellite data. VHI depends on vegetation state and thermal stress, respectively assessed via (i) the Vegetation Condition Index (VCI) that usually relies on information from the visible and near infra-red parts of the spectrum (in the form of Normalized Difference Vegetation Index, NDVI); and (ii) the Thermal Condition Index (TCI), based on top of atmosphere thermal infrared (TIR) brightness temperature or on TIR-derived Land Surface Temperature (LST). VHI is then estimated as a weighted average of VCI and TCI. However, the optimum weights of the two components are usually not known and VHI is usually estimated attributing a weight of 0.5 to both. Using a previously developed methodology for the Euro-Mediterranean region, we show that the multi-scalar drought index (SPEI) may be used to obtain optimal weights for VCI and TCI over the area covered by Meteosat satellites that includes Africa, Europe, and part of South America. The procedure is applied using clear-sky Meteosat Climate Data Records (CDRs) and all-sky LST derived by combining satellite and reanalysis data. Results obtained present a coherent spatial distribution of VCI and TCI weights when estimated using clear- and all-sky LST. This study paves the way for the development of a future VHI near-real time operational product for drought monitoring based on information from Meteosat satellites.
Effects of Forest Canopy Vertical Stratification on the Estimation of Gross Primary Production by Remote Sensing
Authors: Lin Shangrong , Li Jing , Liu Qinhuo , Huete Alfredo , Li Longhui
Published: August 2018

Gross primary production (GPP) in forests is the most important carbon flux in terrestrial ecosystems. Forest ecosystems with high leaf area index (LAI) values have diverse species or complex forest structures with vertical stratifications that influence the carbon–water–energy cycles. In this study, we used three light use efficiency (LUE) GPP models and site-level experiment data to analyze the effects of the vertical stratification of dense forest vegetation on the estimates of remotely sensed GPP during the growing season of two forest sites in East Asia: Dinghushan (DHS) and Tomakomai (TMK). The results showed that different controlling environmental factors of the vertical layers, such as temperature and vapor pressure deficit (VPD), produce different responses for the same LUE value in the different sub-ecosystems (defined as the tree, shrub, and grass layers), which influences the GPP estimation. Air temperature and VPD play important roles in the effects of vertical stratification on the GPP estimates in dense forests, which led to differences in GPP uncertainties from −50% to 30% because of the distinct temperature responses in TMK. The unequal vertical LAI distributions in the different sub-ecosystems led to GPP variations of 1–2 gC/m2/day with uncertainties of approximately −30% to 20% because sub-ecosystems have unique absorbed fractions of photosynthetically active radiation (APAR) and LUE. A comparison with the flux tower-based GPP data indicated that the GPP estimations from the LUE and APAR values from separate vertical layers exhibited better model performance than those calculated using the single-layer method, with 10% less bias in DHS and more than 70% less bias in TMK. The precision of the estimated GPP in regions with thick understory vegetation could be effectively improved by considering the vertical variations in environmental parameters and the LAI values of different sub-ecosystems as separate factors when calculating the GPP of different components. Our results provide useful insight that can be used to improve the accuracy of remote sensing GPP estimations by considering vertical stratification parameters along with the LAI of sub-ecosystems in dense forests.
Assessment of MODIS, OMI, MISR and CALIOP Aerosol Products for Estimating Surface Visual Range: A Mathematical Model for Hong Kong
Authors: Shahzad Muhammad Imran , Nichol Janet Elizabeth , Campbell James R. , Wong Man Sing
Published: August 2018

Estimation of atmospheric visibility (VR) using ground and satellite sensors is ineffective under Hong Kong’s complex atmosphere and climate. Therefore, the relationship between columnar Aerosol Optical Depth (AOD) from four space-borne sensors (OMI, MODIS, MISR and CALIOP) and Bext from two visibility-recording stations was evaluated, to recommend an effective satellite-based method and spatial resolution, for estimation of VR over Hong Kong. Since most column-integrated aerosol particle extinction occurs within a mixing layer height (MLH) of 1–3 km, column-based AOD from satellites is expected to give a good indication of surface-level conditions, especially when MLH is a known input. The AOD from both MODIS and MISR showed high correlations with Bext; therefore, both were subjected to rigorous statistical analysis along with climatic data to simulate visibility. The best estimate of ground visibility was obtained from MODIS AOD combined with surface-level climatic data, and this explained 84% of the variance in VR, with a low distance error of 0.27 km. Results suggest that the water vapor mixing ratio (Q) alone can explain the combined effect of Atmospheric Pressure (P), Temperature (T) and Relative Humidity (RH) on VR, and that the advection term (VT) alone is sufficient to explain the effects of T, WS and WD on dispersion of aerosols, and hence on VR.
Land-Use Carbon Emissions Estimation for the Yangtze River Delta Urban Agglomeration Using 1994–2016 Landsat Image Data
Authors: Cui Yifan , Li Long , Chen Longqian , Zhang Yu , Cheng Liang , Zhou Xisheng , Yang Xiaoyan
Published: August 2018

The amount and growth rate of carbon emissions have been accelerated on a global scale since the industrial revolution (1800), especially in recent decades. This has resulted in a significant influence on the natural environment and human societies. Therefore, carbon emission reduction receives continuously increasing public attention and has long been under debate. In this study, we made use of the land-use specific carbon emission coefficients from previous studies and estimated the land-use carbon emissions and carbon intensities of the Yangtze River Delta Urban Agglomeration (YRDUA)—which consists of 26 eastern Chinese cities—from Landsat image data and socio-economic statistics in 1995, 2005, and 2015. In addition, spatial autocorrelation models including both global and local Moran’s I were used to analyze the spatial autocorrelation of carbon emissions and carbon intensities. It was found that (1) the YRDUA witnessed a rapidly increasing trend for net carbon emissions and a decreasing trend for carbon intensity over the two decades; (2) the spatial differences in carbon intensity had gradually narrowed, but were large in carbon emissions and had gradually increased; and (3) the carbon emissions in 2005 and 2015 had significant spatial autocorrelations. We concluded that (1) from 1995 to 2015 in the YRDUA, carbon emissions were large for the cities along the Yangtze River and carbon intensities were high for Anhui province’s resource-based cities, while both carbon emissions and carbon intensities were small for Zhejiang province’s cities; (2) over two decades, the increase in carbon emissions from urban land was approximately twice the increase in urban land area. Our study can provide useful insights into the assignment of carbon reduction tasks within the YRDUA.
Using Community Detection Analysis to Elucidate Caregivers’ Mental Models of Pediatric Concussion Symptoms
Authors: Goodman Emma , Boe Logan , Thye Melissa , Mirman Jessica
Published: August 2018

Due to a culture of resistance around concussion reporting, novel methods are needed to reveal implicit beliefs that could affect symptom reporting. The goal of this study was to elucidate caregivers’ mental models of pediatric concussion symptoms using an exploratory community detection analysis (CDA). Caregivers (n = 76) of adolescents 10–15 years old participated in a survey that assessed their intentions of seeking medical treatment for 12 injury symptoms following their child’s involvement in three hypothetical injury scenarios. We used a series of analyses of variance (ANOVAs) to compare injury symptoms across these scenarios and CDA to determine if caregivers implicitly group symptoms together. We then used logistic regressions to further explore associations between the CDA-identified symptom indices and known factors of injury risk. There were no differences in the likelihood to seek treatment for symptoms across injury scenarios; however, the CDA revealed distinct symptom clusters that were characterized by the degree of risk for non-treatment and symptom type. We observed associations between injury risk factors and intentions of seeking medical treatment for the higher-risk indices. Results indicate that caregivers’ mental models of concussion symptoms are nuanced, not monolithic. Therefore, it is inaccurate to measure intentions to seek treatment for concussion without taking these nuances into consideration.
Reducing Risks in Energy Innovation Projects: Complexity Theory Perspective
Authors: Mihić Marko M. , Dodevska Zorica A. , Todorović Marija Lj. , Obradović Vladimir Lj. , Petrović Dejan Č.
Published: August 2018

The aim of this paper is to contribute to existing work on project risk management, and energy innovation projects, using the lens of complexity theory. By regarding energy innovation projects as complex adaptive systems, and linking complexity theory elements to the possibilities for reducing risks of energy innovation projects, the authors conducted empirical research on a representative sample of 100 subjects. The authors used a questionnaire that was formed on the basis of a previously designed research model, which unifies several different management fields, and a large number of phenomena previously studied independently. Therefore, it has a holistic approach to the topic. The results of this research suggest that considering the elements of complexity theory had a positive impact on reducing risks in energy innovation projects, in all analyzed aspects including specific, operational, and especially regarding social and behavioral aspects. This paper strives to support and encourage better results in energy innovation projects by reducing their risks, and hopes to bring additional value by introducing a new risk philosophy, based on complexity theory. Lessons learnt regarding each issue of this research are points of concern for project managers.
A Novel Model for Determining Public Service Compensation in Integrated Public Transport Systems
Authors: Stojić Gordan , Mladenović Dušan , Prentkovskis Olegas , Vesković Slavko
Published: August 2018

In free market conditions, if public passenger transport services are commercially unprofitable, there will be no interest for transport companies to perform them. However, directly because of the citizens’ interests, on the one hand, and indirectly because of the economy, passenger public transport services have become of a general public interest. The authorities must prepare appropriate legal fair market conditions, based on which public transport will be subsidized and conducted. In order to achieve that, for the mutual benefit of the public, users and transport companies, it is necessary that the right Public Service Obligation Model (PSO model or in some literature PCS—Public Service Compensation) be defined. Within this study, the optimal approach to assigning a PSC contract to transport companies for performing the PSO in integrated and regular public passenger transport systems is determined. A novel model, presented in this paper, can help national, regional and local authorities to choose and determine the way and level of PSCs for conducting the public transport of passengers and establishing a sustainable public passenger transport system.
An Approach to Study Groundwater Flow Field Evolution Time Scale Effects and Mechanisms
Authors: Wang Dianlong , Zhang Guanghui , Feng Huimin , Wang Jinzhe , Tian Yanliang
Published: August 2018

The temporal scale effect is an important issue for groundwater system evolution research. The selection of an appropriate time scale will enhance the understanding of the characteristics and mechanisms of groundwater flow field evolution. In this study, a methodology was provided to analyze the groundwater system evolution, focusing on the choice of the suitable time step for identifying the distinct stages of evolution, characterized by different behavior linked to the management of the groundwater system. The evolution trend of the groundwater level in the center of the cone of depression at different time scales, combined with the F test and the groundwater system balance index (Re) categories, were used for the choice of the time step and the division of the evolution stages. Based on the transformed groundwater level time series using the selected best time step, the main factors controlling the groundwater evolution were assessed for the different stages. Our results show that the methodology can exactly identify the different important stages of the evolution, and they can be used to individually study these stages, which can help to reveal the mechanisms of the groundwater evolution more easily. Therefore, it is useful to obtain an increased knowledge of the regional groundwater dynamics.
Social Networks Research for Sustainable Smart Education
Authors: Lytras Miltiadis D. , Visvizi Anna , Daniela Linda , Sarirete Akila , Ordonez De Pablos Patricia
Published: August 2018

Social networks research has grown exponentially over the past decade. Subsequent empirical and conceptual advances have been transposed in the field of education. As the debate on delivering better education for all gains momentum, the big question is how to integrate advances in social networks research, corresponding advances in information and communication technology (ICT) and effectively employ them in the domain of education. To address this question, this paper proposes a conceptual framework (maturity model) that integrates social network research, the debate on technology-enhanced learning (TEL) and the emerging concept of smart education.
A Spatial Zoning Model of Municipal Administrative Areas Based on Major Function-Oriented Zones
Authors: Zhao Yujing , Leng Hong , Sun Pingjun , Yuan Qing
Published: August 2018

The multi planning contradictions and maladjustment of spatial management that evolved from an unbalanced development are becoming increasingly serious in China; therefore, it is imperative to know how to coordinate spatial planning. The scientific division of spatial unit attributes and the identification of ecological–agricultural production–living spaces (EPLs) have become the key scientific problems of this period. The existing urban structure zoning model, the urban growth boundary model, and the function-oriented zoning model show three main shortcomings: the difficult data acquisition and the large limitation of the application because of their high requirements of the related parameters, strong subjective weight setting, and lack of comprehensive zoning in the EPLs practice. This paper builds a quantitative and easily operated model for the spatial zoning of municipal administrative areas (MAA) based on the existing spatial equilibrium model for regional development. Three representative cities in China were modeled empirically with this model and the results were compared with those obtained by the existing models. We investigated the image consistency of this model to the three existing models where the Kappa values were 85.9%, 88.2%, and 85.2%, respectively, with an average of 86.4%. This showed that the model could reduce the data limitation and expand the scope of the application while ensuring the accuracy of the model’s analysis results. Meanwhile, the EPLs zoning was clearer, which made the spatial plan coordination more efficient and scientific. Overall, this model could not only solve the problem of the EPLs zoning and spatial plan coordination in MAA, but also guide urban land use planning from two dimensions of space and time and effectively promote the coordination and sustainable development of spatial planning.
Determining Recycling Fees and Subsidies in China’s WEEE Disposal Fund with Formal and Informal Sectors
Authors: Liu Huihui , Wu Xiaolin , Dou Desheng , Tang Xu , Leong G. Keong
Published: August 2018

At present, most of China’s waste electrical and electronic equipment (hereafter referred to as WEEE) flow into the informal recycling sector, which has no official disassembly certification. To regulate the WEEE recycling industry, the policy of the WEEE disposal fund has been implemented to levy recycling fees from producers and subsidize the formal recycling sector. This paper aims to solve the challenging problem of how to optimize recycling fees and subsidies. We first study the competition between the formal and informal sectors, and construct the game models of the dismantling and refurbishing processes. Based on the equilibrium outcomes, we then examine the impact of the disposal fund on producers, as well as the formal and informal recycling sectors. With the goal of maximizing social welfare and maintaining a balanced budget for the disposal fund, we study the optimal recycling fee levied on producers and the corresponding subsidy provided to the formal sector. Social welfare is a function of producer and formal-recycler profits, consumer surplus, and the negative externality caused by informal dismantling and refurbishing, such as environmental pollution and safety problems. Results show that the use of subsidy can increase the acquisition quantity of used products in the formal sector, but the increase will slow down with higher subsidy. If the recycling fee that producers are charged is small, social welfare will be improved. In addition, as the fee is increased, social welfare will rise first and then fall. As such, any excessive increase in recycling fees should be avoided.
Rabies in the Caribbean: A Situational Analysis and Historic Review
Authors: Seetahal Janine F. R. , Vokaty Alexandra , Vigilato Marco A. N. , Carrington Christine V. F. , Pradel Jennifer , Louison Bowen , Sauers Astrid Van , Roopnarine Rohini , Arrebato Jusayma C. González , Millien Max F. , James Colin , Rupprecht Charles E.
Published: August 2018

Rabies virus is the only Lyssavirus species found in the Americas. In discussions about rabies, Latin America and the Caribbean are often grouped together. Our study aimed to independently analyse the rabies situation in the Caribbean and examine changes in rabies spatiotemporal epidemiology. A questionnaire was administered to the 33 member countries and territories of the Caribbean Animal Health Network (CaribVET) to collect current data, which was collated with a literature review. Rabies was endemic in ten Caribbean localities, with the dog, mongoose, and vampire bat identified as enzootic reservoirs. The majority of animal cases occurred in Puerto Rico, the Dominican Republic, and Haiti, while human cases only consistently occurred in the latter two areas. Rabies vaccination was conducted for high-risk animal populations with variable coverage, and rabies diagnostic capacities varied widely throughout the region. Illegal importation and natural migration of animals may facilitate the introduction of rabies virus variants into virus-naïve areas. Passive surveillance, together with enhanced methods and serological screening techniques, can therefore be of value. The insularity of the Caribbean makes it ideal for conducting pilot studies on reservoir host population management. Best practice guidelines developed for these reservoir hosts can be individually modified to the epidemiological status and available resources within each locality.
Who’s Driving? Human Cytomegalovirus, Interferon, and NFκB Signaling
Authors: Goodwin Christopher M. , Ciesla Jessica H. , Munger Joshua
Published: August 2018

As essential components of the host’s innate immune response, NFκB and interferon signaling are critical determinants of the outcome of infection. Over the past 25 years, numerous Human Cytomegalovirus (HCMV) genes have been identified that antagonize or modulate the signaling of these pathways. Here we review the biology of the HCMV factors that alter NFκB and interferon signaling, including what is currently known about how these viral genes contribute to infection and persistence, as well as the major outstanding questions that remain.
Recent Changes in the Occurrences and Damages of Floods and Droughts in the United States
Authors: Zhou Qianqian , Leng Guoyong , Peng Jian
Published: August 2018

In this study, we compile and analyse 136,920 records of flood and 50,967 records of drought from a survey-based database to investigate recent changes in annual occurrence and economical cost in the United States. Results show that an average of 6520 floods has occurred per year during 1996–2016, with annual mean economic losses up to 3986 million US dollars, while 2427 drought events/year are recorded causing an average loss of 1684 million US dollars per year. Importantly, we found there is no evident changing tendency in annual economic damages of floods and droughts, despite an upward trend in their annual occurrences. This could be partly explained by changes in regional vulnerabilities, as indirectly reflected by the ratio of damaging events to total number of events experienced and the average damage per event. Spatially, vulnerability to droughts has decreased in most of the country, while increased vulnerability to floods is observed in a number of states. Despite limitations from the records and incomplete characterization of vulnerability, this study has great implications for targeted mitigation and adaptation, through identifying the regions that are most vulnerable to floods and droughts respectively and highlighting the contrasting patterns in regional vulnerability to floods and droughts.