bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Gas Phase Stability of Heme‐binding Pocket in Cytochrome Tb5 and Its Mutants by Electrospray Mass Spectrometry
Authors: Yu Chong‐Tian , Guo Yin‐Long , Lü Long , Wang Yun‐Hua , Yao Ping , Huang Zhong‐Xian
Published: September 2010

To elucidate the effect of various amino add residues on the heme‐binding pocket in cytochrome Tb5, several residues were chosen for replacement by means of site‐directed mutagenesis. Comparison of the mass spectrum between the F35Y mutant and the wild type shows that the relative abundance of holoprotein ion of F35Y is lower than that of the wild type in gas phase. It is concluded that mutation from Phe35 residue to tyrosine decreases the hydrophobic character of cytochrome Tb5 heme pocket, which decreases the stability of heme‐binding pocket. ESI‐MS spectra of the mutants V61E, V61K, V61H and V61Y show various contribution of amino acid to the stability of heme‐binding pocket. The small and non‐polar residue Val61 was replaced with large or polar residues, resulting in enhancing the trend of heme leaving from the pocket. In addition, comparison of the mass relative abundance of holo‐proteins among all the Vakil‐mutants, shows mat their stability in gas phase appropriately submit the following order: wild type > V61H > V61E > V61K ≈︁ V61Y. The extra great stability of quadruple sites mutant E44/48/56A/D60A shows that reduction of electrostatic or hydrogen bond interactions among the residues locating in the outside region of the heme edge remarkably affect the stability of heme. The results of analyzing the oxidation states of heme iron in Tb5 and its mutants by insource‐CAD experiment suggest that the charge states of heme iron Maintain inflexible in mutation process.
Resonance Rayleigh Scattering Method for the Determination of Raloxifene with Evans Blue
Authors: Fan Li , Liu Shao‐Pu , Yang Da‐Cheng , Hu Xiao‐Li
Published: September 2010

The intensity of resonance Rayleigh scattering (RRS) of Evans blue (EB) or raloxifene hydrochloride (Ralo) is very weak, but it can be enhanced significantly and a new RRS spectrum appears when both of them interact to form an ion‐association complex in sodium acetate‐hydrochloric acid buffer solution at pH 1.8. The intensity of RRS is directly proportional to the concentration of Ralo in the range of 0–8.3 μg · mL−1, and the detection limit for Ralo (σ = 3) is 18.9 ng·mL−1. The method has high sensitivity and fairly good selectivity. Based on the above evidences, a new facile method for the determination of trace amount of Ralo has been established with satisfactory results.
A Novel Polybrene/Chondroitin Sulfate C Double Coated Capillary and Its Application in Capillary Electrophoresis
Authors: Du Ying‐Xiang , Honda Susumu , Taga Atsushi , Liu Wen‐Ying , Suzuki Shigeo
Published: September 2010

A new capillary coated by double polymer, polybrene/chondroitin sulfate C (P/CC), was developed using a simple procedure. The P/CC double coated capillary showed long lifetime, strong chemical stability and good reproducibility. It endured during more than 100 replicated analyses and was also tolerant to HCl (1 mol/L), NaOH (0.01 mol/L), CH3OH and CH3CN. The P/CC double coated capillary can be applied to basic drug analyses. The adsorption of basic drugs to the capillary wall was suppressed and the peak tailing greatly decreased. The use of the P/CC double coated capillary allowed excellent separation of the enantiomers of some basic drugs by using chondroitin sulfate C as the chiral selector, and the peak symmetry of basic drugs was further improved under these conditions.
Synthesis of 2‐Benzylthio‐5‐phenyl‐3,4‐disubstituted Thiophenes by Intramolecular Condensation of α‐Oxo Ketene Dibenzyl‐thioacetals
Authors: Wang Mang , Ai Lin , Zhang Ji‐Yu , Liu Qun , Gao Lian‐Xun
Published: September 2010

A facile route to 2‐benzylthio‐5‐phenyl‐3,4‐disubstituted thiophenes was described. Catalyzed by sodium hydroxide, the title compounds were synthesized in moderate to good yields simply from the intramolecular aldol type condensation of α‐oxo ketene dibenzylthioacetals. The chemical selectivity for this annulation reaction was studied and discussed.
Synthesis, Mechanism of Formation and Insecticidal Activity of Novel Fluorinated Organophosphorus Compounds
Authors: Wu Jun , Hudson Harry R.
Published: September 2010

The major products of the interaction between triethyl phosphite and 3‐fluoropropanoyl chloride at room temperature are diethyl (E)‐1‐(3‐fluoropropanoyloxy)‐3‐fluoroprop‐1‐enylphosphonate (3) and diethyl l‐(diethoxyphosphoryl)‐3‐fluoropropyl phosphate (4). The compounds 3 and 4 were separated by chromatography, and structurally characterized by elemental analysis, NMR spectroscopy (1H, 13C, 19F and 31P) and mass spectrometry. Possible reaction mechanisms are proposed. The major products 3 and 4 were tested for insecticidal activity. 3 gave 100% control of Musca domestica L. and Phaedon cochledriae Fab. at a dose of 20 μg/per insect.
Synthesis, Properties and Crystal Structure of Seven‐coordinated Organotin Complex [nBu2Sn(OOCC5H4N‐2)2(H2O)]
Authors: Yin Han‐Dong , Wang Chuan‐Hua , Ma Chun‐Lin , Wang Yong
Published: September 2010

A novel seven‐coordinated organotin complex [nBu2Sn‐(OOCC5H4N‐2)2(H2O)] was unexpectedly synthesized by reaction of nBu3SnCl with 2‐pyridinecarboxylic acid in 1:1 molar ratio in the presence of organic base Et3N. The crystal structure was determined by single crystal X‐ray diffraction analysis. The crystal belongs to rhombohedral with space group R‐3c, a = 1.5807(3) nm, b = 1.5807(3) nm, c = 1.5807(3) nm, α = 105.717(2)°, β = 105.717(2)°, γ = 105.717(2)°, Z = 6, V = 3.397(8) nm3, Dc = 1.452 g/cm3, μ = 1.158 mm−1, F(000) = 1512, R1 = 0.0447, wR2 = 0.1038. In crystal, the tin atoms rendered seven‐coordinate in a distorted pentagonal bipyramidal geometry. The two‐dimensional network structure was formed by H‐bonding interaction between the free oxygen atoms of carboxyl groups and the coordinated water molecules.
A New Approach on the Active Treatment for Electroless Copper Plating on Glass
Authors: Zheng‐Chun Liu , Quan‐Guo He , Jian‐Xin Tang , Peng‐Feng Xiao , Nong‐Yue He , Zu‐Hong Lu
Published: September 2010

A new method is described for the electroless deposition of copper onto glass. Commercially available glass slide was modified with μ‐amimopropyltrimethoxysilane to form self‐assembled monolayer (SAM) on it. Then it was dipped directly into PdCl2 solution instead of the conventional SnCl2 sensitization followed by PdCl2 activation. Experimental results showed that the Pd2+ ions from PdCl2 solution were coordinated to the ammo groups on the glass surface resulting in the formation of N—Pd complex. In an electroless copper bath containing a formaldehyde reducing agent, the N—Pd complexes were reduced to Pd0 atoms, which then acted as catalysts and initiated the deposition of copper metal. Although the copper deposition rate on SAM‐modified glass was slow at the beginning, it reached to that of conventional method in about 5 min.
Lipases‐Catalyzed Alcoholysis for the Preparation of Chiral 1‐ or 2‐Hydroxyalkanephosphonates
Authors: Yong‐Hui Zhang , Jin‐Feng Li , Ke Wang , Cheng‐Ye Yuan
Published: September 2010

Enzymatic alcoholysis has been developed for the preparation of some chiral 1‐ and 2‐hydroxyalkanephosphonates with high optical purity. This method ensures the convenient access to the optically pure phosphocarnitine, phosphogabob and phosphomycin.
Oxidative Splitting of a Pyrimidine Cyclobutane Dimer: A Pulse Radiolysis Study
Authors: Li‐Qin Yan , Qin‐Hua Song , Xiao‐Ming Hei , Qing‐Xiang Guo , Wei‐Zhen Lin
Published: September 2010

The oxidative splitting process of cis‐syn 1,3‐dimethyluracil cyclobutane dimer (DMUD) in aqueous solution was investigated using pulse radiolysis technique. The results indicated that DMUD can be splitted into 1,3‐dimethyluracil (DMU) by OH radicals (OH·) and Br2 radical anions (Br·2−), but not by azide radicals (N·3). The oxidative mechanisms that an H‐abstracted from DMUD for OH· oxidative splitting and an electron transfer from DMUD to Br·2−, were suggested. Related kinetic parameters were determined.
Synthesis, Structure and Optical Properties of Cupro‐8‐thioquinoline Coordination Polymer, [CuI (C9H6NS)]n
Authors: Guo‐Hong Zhang , Ping Wang , Hong‐You Guo , Nian‐Zu Wu , Xiang‐Lin Jin
Published: September 2010

A Cupro‐8‐thioqinoline coordination polymer, [CuI (C9H6NS)]n, was synthesized by methano‐thermal reaction of CuCl and 8,8′‐dithiodiquinoline (dtdq) in a molar ratio of 2:1 at 160°C for 7 d. X‐Ray single crystal structure determination revealed the formation of a one‐dimensional structure belonging to monoclinic crystal system, space group P21/c with cell parameters a = 0.8043(1) nm, b = 1.8949(3) nm, c = 1.1048(1) nm, β = 110.109(4)°, V = 1.5810(4) nm3 and Z = 4. The crystal was found to be stable up to approximately 300°C by thermal analysis and have an energy gap (Eg) of 2.0 eV exhibited by UV‐Vis‐NIR reflectance spectrum.
Novel Chiral Aminophosphine Ligand: Synthesis and Application in Asymmetric Catalytic Hydrogenation Reaction
Authors: Yi‐Xin Chen , Yue‐Ming Li , Kim‐Hung Lam , Sun‐Chi Chan Albert
Published: September 2010

A new chiral aminophosphine ligand 6,6′‐dimethoxy‐2,2′‐bis(diphenylphosphinoamino) biphenyl (DMBDPPABP) was prepared and its rhodium complex was found to be an effective catalyst for the asymmetric hydrogenation of amidoacrylic add and its derivatives. The effects of solvent and reaction temperature on enantioselectivity were also studied.
Effect of Particle Size and Capping on Photoluminescence Quantum Efficiency of 1,3,5‐Triphenyl‐2‐pyrazoline Nanocrystals
Authors: De‐Bao Xiao , Ztt‐Yum Han , Lu Xi , Li‐Yim Zhao , Wen‐Sheng Yang , Jian‐Nian Yao
Published: September 2010

Organic nanocrystals of 1,3,5‐triphenyl‐2‐pyrazoline (TPP) with a series of sizes were synthesized by reprecipitation method. The luminescence quantum efficiency of TPP nanocrystals increases from 24.2% for the nanocrystals with an average size of 300 nm to 34.6% for those with an average size of 20 nm. Surface capping by polyvinyl pyrrolidone (PVP) will improve the quantum efficiency of TPP nanocrystals. The size‐dependence and capping‐induced variation of the luminescence quantum efficiency was elucidated in viewpoint of aggregation quenching and the equilibrium between the TPP monomers and the aggregates in TPP nanocrystals.
Synthesis and Chiral Recognition of a New Type of Chiral Calix[4]‐arene Derivatives
Authors: Yong‐Bing He , Jian‐Feng Li , Yuan‐Jing Xiao , Lan‐Hua Wei , Xko‐Jun Wu , Ling‐Zhi Meng
Published: September 2010

Two new chiral calix[4]arenes bearing chiral pendants, which were from by‐product of the antibiotic industry, were synthesized and characterized by 1H NMR, MS‐FAB and elemental analysis. Studies of 1H NMR of the two calix[4] arene derivatives indicate that they exist in cone conformation in solution. Results of chiral recognition of the two chiral ligands 2a and 2b towards the tartaric add derivative 3 show that ligand 2a exhibited good chiral recognition abilities compared to ligand 2b.
Hyperbranched Acrylated Aromatic Polyester Used as a Modifier in UV‐Curable Epoxy Acrylate Resins
Authors: Hui‐Guang Kou , Anila Asif , Wen‐Fang Shi
Published: September 2010

The viscosity, the shrinkage degree and the photopolymerization rate of the epoxy acrylate (EB600) blended with hyperbranched acrylated aromatic polyester (HAAPE) were investigated. The addition of HAAPE into EB600 largely reduces the viscosity of the blend formulation and the shrinkage degree. For example, EB600 resin with 50% weight fraction of HAAPE has the 1250 cps of the viscosity and 2.0% of shrinkage degree, while the pure EB600 resin has 3000 cps of the viscosity and 10.5% of shrinkage degree. The photopolymerization rate of the resin is also promoted by HAAPE addition. The good miscibility between HAAPE and EB600 was also observed from the dynamic mechanical analysis. The tensile, flexural and compressive strength, and the thermal properties of the UV cured films are greatly improved.
High Power Density Electric Double Layer Capacitor with Improved Activated Carbon
Authors: Hui Yang , Hui‐Jun Jiang , Tian‐Hong Lu
Published: September 2010

The improvement on commercial activated carbon (AC) through the reactivation under steam in the presence of NiCl2 catalyst leads to the increases of both energy and power densities of electric double layer (dl) capacitors. When AC was treated at 875 °C for 1 h, its discharge specific capacitance increases up to 53.67 F· g−1, an increase of about 25% compared to the as‐received AC. Moreover, a significant increase in high rate capability of electric dl capacitor was found after the improvements. Surprisingly, both the treated and untreated AC samples showed similar specific surface area and pore size distribution, but some changes in the surface groups and their concentrations after reactivation were verified by X‐photoelectron spectra. Thus, it is reasonable to conclude that the decrease in the surface concentration of the carbonyl‐containing species for the improved AC results in an increase of accessibility of the pores to the organic electrolyte ion, causing the enhancements of both the specific capacitance and high rate capability.
Bonding and Mössbauer Isomer Shifts in (Hg, Pb)‐1223 Cuprate
Authors: Fa‐Ming Gao , Yong‐Jun Tian , Yan Chen , Dong‐Chun Li , Hai‐Feng Dong , Si‐Yuan Zhang
Published: September 2010

By using the chemical bond theory of dielectric description, the chemical bond parameters of (Hg, Pb)‐1223 were calculated. The results show that the (Ba, Sr)‐O and Ca—O types of bond have higher ionic character, while the Cu—O and (Hg, Pb)‐O types of bond have more covalent character. Mössbauer isomer shifts of 57Fe and 119Sn doped in (Hg, Pb)‐1223 were calculated by using the chemical environmental factor, he, defined by covalency and electronic polarizability. Four valence state tin and three valence iron sites were identified in 57Fe and 119Sn doped (Hg, Pb)‐1223 superconductor. It can be concluded that all of the Fe atoms substitute the Cu at square planar Cu(1) site, whereas Sn prefers to substitute the square pyramidal Cu(2) site.
Theoretical Study on Gas‐phase Pyrolytic Reactions of N‐Ethyl, N‐Isopropyl and N‐t‐Butyl Substituted 2‐Aminopyrazine
Authors: Li‐Ping Chen , San‐Guo Hong
Published: September 2010

Density functional theory (DFT) and ab initio methods were used to study gas‐phase pyrolytic reaction mechanisms of iV‐ethyl, N‐isopropyl and N‐t‐butyl substituted 2‐aminopyrazine at B3LYP/6–31G* and MP2/6–31G*, respectively. Single‐point energies of all optimized molecular geometries were calculated at B3LYP/6–311 + G(2d,p) level. Results show that the pyrolytic reactions were carried out through a unimolecular first‐order mechanism which were caused by the migration of atom H(17) via a six‐member ring transition state. The activation energies which were verified by vibrational analysis and correlated with zero‐point energies along the reaction channel at B3LYP/6–311 + G(2d,p) level were 252.02 kJ. mo−1 (N‐ethyl substituted), 235.92 kJ‐mol−1 (N‐t‐isopropyl substituted) and 234.27 kJ‐mol−1 (N‐t‐butyl substituted), respectively. The results were in good agreement with available experimental data.
Synthesis of Substituted Indenyl Lanthanide Chloride and Molecular Structure of [(C5H9C9H6) 2Yb (μ‐Cl) 2Li (Et2O)2]
Authors: Dong‐Mei Cui , Tao Tang , Jian‐Hua Cheng , Wen‐Qi Chen , Bao‐Tong Huang
Published: September 2010

Reaction of anhydrous ytterbium trichlorides with 2 equiv. of cyclopentylindenyl lithium in THF solution, followed by removal of the solvent and crystallization of the product from diethyl ether, affords a crystal complex of the composition (C5H9C9H6)2Yb (μ‐Cl)2Li(Et2O)2. Crystallographic analysis shows that the ytterbium coordinated by two cyclopentylindenyl rings and lithium surrounded by two ether molecules are bridged by the two chlorine atoms and Yb, Li and two chlorine atoms form a plane.
In Situ Monitoring of the Generation of Monodisperse Silica Particles during the Hydrolysis of Tetraethyl Orthosilicate with Piezoelectric Quartz Crystal Impedance Analyzer
Authors: You‐Yu Zhang , Qing‐Ji Xie , Shou‐Zhuo Yao
Published: September 2010

The piezoelectric quartz crystal (PQC) impedance analyzer was used to monitor in situ the generation of monodisperse silica particles during the hydrolysis of tetraethyl orthosilicate (TEOS) and their adsorption onto an Au electrode in alcohol solutions containing water (6–15 mol/L) and ammonia (0.2–2.0 mol/L). The equivalent circuit parameters, the resonance frequencies and the half‐peak width values of the conductance spectra of the PQC resonance were obtained. The resonant frequency decreased notably while the motional resistance changed very slightly (within 1 ω) during the hydrolysis reaction, suggesting that the mass effect dominated the adsorption of generated monodisperse silica particles on the gold electrode in this system. Changes in f0 indicated that the ammonia concentration affected the hydrolytic reaction obviously, and the influence of water concentration on the reaction was small while the water was significantly excessive. Kinetics of monodisperse silica particle adsorption occurring at the electrode solution interface was analyzed using a first‐order reaction scheme. In addition, the electrolyte‐induced precipitation of the monodisperse silica particles was monitored and discussed. The mean size, the number of adsorbed particles per area and the converge of monodisperse silica particles were obtained from scanning electron microscope (SEM) observations.
Langmuir Aggregation of Thionin in Nucleic Acids and Its Application
Authors: Hong‐Wen Gao
Published: September 2010

The microsurface adsorption‐spectral correction (MSASC) technique has been described. The formation of the double electrostatic films in nucleic acids causes the monolayer aggregation of stain molecules. The interaction of thionin (TN) with nucleic acids, ctD‐NA, sDNA and yRNA, has been investigated at pH 7.8. Results show that the binding ratios of TN to ctDNA‐P, sDNA‐P and yR‐NA‐P are 1.27, 1.30 and 1.40, respectively, the binding constants of the aggregates are 2.8 · 104, 9.10 · 104 and 6.49 · 103 and their molar absorptivities are 1.04 · 104, 1.25 · 104 and · 104 L· mol−1, cm−1 at 630 nm. The aggregation may be applied to the spectrophotometric detection of nucleic acids samples.
Synthesis of Ultra‐high Molecular Weight Polystyrene with a Catalyst System Based on Calixarene‐yttrium Complex
Authors: Yao‐Feng Chen , Yi‐Feng Zhang , Zhi‐Quan Shen
Published: September 2010

Polymerization of styrene (St) with a new catalyst system composed of calixarene‐yttrium complex, magnesium‐aluminium alkyls and hexamethyl phosphoramide was studied. Hie catalyst system shows extremely high activity (> 7 × 106 g PSt/mol Y × h) and gives polystyrene with very high viscosity‐average molecular weight (>5 × 105).
Ab initio Valence Bond Study on AB‐type Molecules. A Description for XH (X = Li, Be, B, C, N, O, F) and XF (X = Li, Be, B)
Authors: Xin‐Li Liao , Yi‐Rong Mo , Wei Wu , Qian‐Er Zhang
Published: September 2010

Ab initio valence bond method is employed to quantitatively study the concepts of ionic resonance energy and ionicity of a chemical bond in the cases of hydrides XH (X = Li, Be, B, C, N, O, F) and fluorides XF (X = Li, Be, B). By establishing the relationship between resonance and stability, and comparing the calculated ionicities with Pauling's earlier estimations in the above diatomic molecules, the merits of Pauling's classical resonance theory were demonstrated at the ab initio level.
Crystal Structure and Characterization of a Large Polyoxotungstate (NH4)21{La(H2O)5[Ni(H2O)]2As4W40O140}·53H2O
Authors: Gang‐Lin Xue , Bin Liu , Wen‐Liang Wang , Qian‐Ding Li , Ji‐Wu Wang , Da‐Qi Wang
Published: September 2010

The heteropolytungstate (NH4)21{La(H2O)5[Ni(H2O)]2As4W40O140}·53H2O is obtained by the reaction of Na27[NaAs4W40O140]· 60H2O with NiCl2·6H2O, La(NO3)3·6H2O and NH4Cl at pH‐4.5. The structure and chemical composition are determined by X‐ray diffraction analysis and elemental analysis. The crystal data and main structure refinement are a = 1.9551(3) nm, b = 2.4156(4) nm, c= 3.7068(6) nm, β = 91.505(3)°, V = 17.500 (5) nm3, monoclinic crystal system with space group P21/n, Z = 4, R1 = 0.0573, wR2 = 0.0717 [I >2<s̀(I)], R1, = 0.2463 and wR2 = 0.1199 (all data). [La(H2O)5] {Ni(H2O)}2AS4W40O140 has C2, symmetry. IR spectra of the ligand [NaAs4W40O140]27‐ and its three complexes were discussed.
An Integrated Theory of Adsorption and Partition Mechanism and Each Contribution to Solute Retention in Reversed Phase Liquid Chromatography
Authors: Xin‐Du Geng , Fred E Regnier
Published: September 2010

With the combination of the the stoichiometric displacement model for retention (SDM‐R) in reversed phase liquid chromatography (RPLC) and the stoichiometric displacement model for adsorption (SDM‐A) in physical chemistry, the total number of moles of the re‐solvated methanol of stationary phase side, nr, and that of solute side in the mobile phase, q, corresponding to one mole of the desorbing solute, were separately determined and referred as the characterization parameters of the contributions of the adsorption mechanism and partition mechanism to the solute retention, respectively. A chromatographic system of insulin, using mobile phase consisting of the pseudo‐homologue of alcohols (methanol, ethanol and 2‐propanol)‐water and trifluoroacetic add was employed. The maximum number of the methanol layers on the stationary phase surface was found to be 10.6, only 3 of which being valid in usual RPLC, traditionally referred as a volume process in partition mechanism. However, it still follows the SDM‐R. Both of q and nr of insulin were found not to be zero, indicating that the retention mechanism of insulin is a mixed mode of partition mechanism and adsorption mechanism. When methanol is used as the organic modifier, the ratio of q/nr was 1.13, indicating the contribution to insulin retention due to partition mechanism being a bit greater than that due to adsorption mechanism. A linear relationship between q, or nr and the carbon number of the pseudo‐homologue in the mobile phase was also found. As a methodology for investigating the retention mechanism retention and behaviors of biopolymers, a homologue of organic solvents as the organic modifier in mobile phase has also been explored.
Synthesis of Novel Quinazoline Derivatives as Antimicrobial Agents
Authors: Aly A. A.
Published: September 2010

Quinazoline isothiocyanate 1 reacts with various nucleophiles (nitrogen nucleophiles, oxygen nucleophiles and sulphur nucleophiles) to afford heterocyclic systemes 2–13. Also, the [4 + 2] cycloaddition reaction of 1 with phenyl isocyanate, benzylidene aryl amine and cinnamic acid derivatives gave novel heterocyclic compounds 14–16. Moreover, the reaction of 1 with active methylene compounds under Michael reaction conditions also was investigated to yield 17 and 18 and it was found that all these reactions proceeded via isothiocyanate heterocyclization to furnish non‐condensed heterocyclic compounds. Some of the newly synthesized compounds were tested for their antimicrobial activities.
Synthesis of Mixed‐ring Zirconocene Complexes Containing Alkenyl Group and Ethylene Polymerization Catalyzed with Them
Authors: Yan‐Long Qian , Xian‐Miao Qian , Ji‐Ling Huang , Jun‐Quan Sun
Published: September 2010

Four new mixed‐ring zirconium completes, [CH2 = CH(CH2)n ‐C5H4](RC5H4)ZrCl2 [n = l, R = CH3OCH2CH2(3); n = 2, R = CH3OCH2CH2 (4); n = 2, R=Me3Si (5); n = 2, R = allyl (6)], have been prepared by the reaction of CH2 = CH(CH2)n C5H4ZrCl3, DME[n = l (1); n = 2 (2)] with RC5H4Li. When activated with methylaluminoxane (MAO), the catalytic activities of the above complexes in ethylene polymerization were tested. Complexes 5 and 6 show high activities similar to Cp2ZrCl2. Introduction of methoxyethyl group into Cp‐ligand dramatically decreases the catalytic activities of complexes 3 and 4, which can be overcome by increasing the amount of MAO. For complex 5, the dependence of activity and molecular weight (Mη) on the Al/Zr ratio, the polymerization time (tP), polymerization temperature (TP) and the polymerization solvent volume (V) was investigated.
Synthesis and Insulin‐sensitizing Activity of a Series of 2‐Benzyl‐1,3‐dicarbonyl Derivatives
Authors: Lei Tang , Ying Leng , Huo‐Quan Wang , Ying Feng , Yu‐She Yang , Ru‐Yun Ji
Published: September 2010

A series of 2‐benzyl‐1,3‐dicarbonyl derivatives was synthesized. Their insulin‐sensitizing activity was evaluated in 3T3‐L1 preadipocyte cells. Compounds 3, 26 and 27 were found to possess strong insulin‐sensitizing activity in vitro and were selected for further hypoglycemic evaluation in vivo.
3‐Mercaptopropionic Acid Capped Gold Nanoclusters: Quantized Capacitance in Aqueous Media
Authors: Di Li , Jing‐Hong Li
Published: September 2010

3‐Mercaptopropionic add monolayer protected gold nanoclusters (MPA‐MPCs) were synthesized and characterized by transmission electron microscopy, UV‐Vis spectroscopy, X‐ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. The exact value of quantized double‐layer capacitance of MPCs in aqueous media was obtained by differential pulse voltammograms.
Synthesis, Spectroscopic Characterization and Antitumor Activity in vitro of Organometallo Substituted Polyoxotungstates (RM)3P2W15‐ On59 (RM=CpTi, CpZr, C4H7O2Sn or C5H9O2Sn)
Authors: Xiao‐Hong Wang , Jiang‐Hua He , Rong‐Chang Zhang , Jing‐Fu Liu
Published: September 2010

Tetrabutylammonium or potassium salts of organometallic derivatives of lacunary polyanion (RM)3P2W15Qn59‐ (RM = CpTl, CpZr, C4H7Q2Sn or C5H9C2Sn) have been prepared and structurally characterized by elemental analysis, IR, UV‐vis, 1H NMR and 183 W NMR spectroscopies. The title complexes exhibit antitumor activity in vitro.
Separation of Basic Drugs Using Pressurized Capillary Electrochromatography
Authors: Kai Zhang , Zhi‐Chao Zhang , Qin‐Sun Wang , Ru‐Yu Gao , Chao Yan , Chuan‐Yi Yao , Zheng‐Jin Jiang
Published: September 2010

A novel pressurized capillary electrochromatography (PCEC) was developed to separate basic drugs on strong cation exchange (SCX) column. The separation result by using PCEC was better than that by using micro‐HPLC. The effects of electrical field and pressure on plate height and resolution were investigated. Influence of organic modifier, ionic strength and pH value of buffer on retention behavior were evaluated, and the separation mechanism was also discussed.
Study on Frequency Doubling Scattering and Second‐Order Scattering Spectra of Heparin‐Methylene Blue System
Authors: Shao‐Pu Liu , Hong‐Qun Luo , Nian‐Bing Li , Zhong‐Fang Liu
Published: September 2010

Binding of heparin with methylene blue (MB) in pH 5.7 Britton‐Robinson buffer can result in a significant enhancement of frequency doubling scattering (FDS) and second‐order scattering (SOS). Their maximum scattering wavelengths (λmax) appear at 350 nm for EDS and 700 nm for SOS, respectively. The optimum conditions of the reaction, the influencing factors and the relationship between the two scattering intensities and the concentration of heparin have been investigated. The new methods for the determination of trace amounts of heparin based on the FDS and SOS methods have been developed, which exhibit high sensitivities. The detection limits of heparin are 4.36 ng/mL for the FDS method and 3.55 ng/mL for the SOS method, respectively. Both of the methods have fairly good selectivity and were applied to the determination of heparin in sodium heparinate injection samples with satisfactory results. Moreover, the relative mechanisms have also been discussed.
Solvothermal Synthesis and Crystal Structure of a Novel Inorganic‐Organic Hybrid Material, Fe2O(OH)(C5H4NCOO)SO4
Authors: Hong‐You Guo , Zeng‐He Li , Xiu‐Yan Li , Chang‐Yuan Zhang , Ru‐Ji Wang
Published: September 2010

A novel inorganic‐organic hybrid material, Fe2O(OH)(C5H4‐NCOO)SO4 was synthesized via solvothermal route using a reaction of FeCl3 ·6H2O, KCNS, and 4‐cyanopyridne in aqueous solution of H2O2 and ethanol at 130 °C for 3 d. The compound crystallized in monoclinic space group P21, with cell parameters a=0.73850(15) nm, b = 0.65100(13) mn, c = 1.0546(2) nm, β = 90.36(3)°, V = 0.50700(18) nm3 and Z = 2. The structure is constructed with inorganic layered [Fe2O(OH) SO4]+ cations linked by organic (C5H4NCOO)− anions. The compound is thermally stable up to approximately 240 °C.
Stereoselective Synthesis of (E)‐ and (Z)‐1,2‐Disubstituted Ethene from Polymer‐Supported Vinylic Selenide
Authors: Shou‐Ri Sheng , Xian Huang
Published: September 2010

This letter describes a method for the stereoselective synthesis of polymer‐supported vinylic selenides and their applications to synthesis of (E)‐ and (Z)‐1,2‐disubstituted ethenes on solid‐phase by the coupling reaction with Grignard reagents under the catalysis of NiCl2(PPh3)2.
Design and Theoretical Study of Nickel Catalysts for Syndiotactic Polyolefins
Authors: Ying Liu , Yue Liu , Jia‐Wen Liu , Michael Drew G. B.
Published: September 2010

A nickel catalyst was modeled with ligand L2, [NH = CH—CH = CH—O]−, which should have potential use as a syndiotactic polyolefin catalyst, and the reaction mechanism was studied by theoretical calculations using the density functional method at the B3LYP/ LANL2MB level. The mechanism involves the formation of the intermediate [NiL2Me]+, in which the metal occupies a T‐shaped geometry. This intermediate has two possible structures with the methyl group trans either to the oxygen or to the nitrogen atom of L2. The results show that both structures can lead to the desired product via similar reaction paths, A and B. Thus, the polymerization could be considered as taking place either with the alkyl group occupying the position trans to the Ni—O or trans to the Ni—N bond in the catalyst. The polymerization process thus favors the catalysis of syndiotactic polyolefins. The syndiotactic synthesis effects could also be enhanced by variations in the ligand sub‐stituents. From energy considerations, we can conclude that it is more favorable for the methyl group to occupy the trans‐O position to form a complex than to occupy the trans‐N position. From bond length considerations, it is also more favoured for ethene to occupy the trans‐O position than to occupy the trans‐N position.
Crystal Structures and Magnetic Studies of Naphthalene Derivatives Containing Nitronyl Nitroxides
Authors: De‐Qing Zhang , Hong‐Qing Zhu , Liang Ding , Wei Xu , Wei Liu , Dao‐Ben Zhu
Published: September 2010

Crystal structures of new nitronyl nitroxide derivatives 1, 2 and 3 were determined with X‐ray diffraction analysis: 1, monoclinic, C2/c, a = 1.2404(5) nm, b = 0.9730(5) um, c = 2.7049(10) ran, β = 98.189(15)°, V = 3.2315(24) nm3, Z = 8; 2, or‐thorhombic, Pbca, a = 0.61262(2) nm, b = 1.11426(6) nm, c = 2.30543(13) nm, V = 1.57373(13) nm3, Z = 4; 3, monoclinic, P2(1)/n, a=0.64253(4) nm, b=2.55003(17) nm, c = 1.15497(6) nm, β = 95.000(3)°, V = 1.8852(2) nm3, Z = 4. Their magnetic properties were measured with SQUID and analyzed based on their crystal structures with simple singlet‐triplet, modified one dimensional antiferromagnetic chain and modified singlet‐triplet models respectively: 1, J/kb= −2.5 K; 2, J/kb = 7.8 K, θ = 2.8 K; 3, J/kb = −0.96 K, θ = 0.21 K.
Zn2+ Recognition by Two New Bipyridine Ligands
Authors: Lin‐Qing Song , Yuan‐Jun Hou , Xue‐Song Wang , Bao‐Wen Zhang , Pu‐Hui Xie , Chang‐Qi Ma , Yi Cao
Published: September 2010

Two new bipyridine ligands with intramolecular charge transfer (ICT) transition as the lowest excited state were designed and synthesized. Upon addition of metal ions, particularly Zn2+, the absorption and emission spectra experience great changes. The binding constants towards Zn2+ are 1.27 × 105 L/mol and 1.66 × 105 L/mol for ligands 1 and 2, respectively. The strong binding affinity and high selectivity make them attractive for application as fluorescence sensors for Zn2+.
Syntheses, Characterization and Equilibrium between Mono‐and Aqua‐bridged Dicobalt(II) Complexes. A Structural Model for Methionine Aminopeptidase
Authors: Bao‐Hui Ye , Xiao‐Ming Chen
Published: September 2010

A monomeric complex [Co(Im)2(O2CMe)2] (1) and a novel aquabridged dimeric complex [Co2(μ‐H2O)(μ‐CMe)2(Im)4‐(O2CMe)2] (2) (Im = imidazole) have been synthesized and characterized. Complexes 1 and 2 coexisted in solution. Pure forms of either complex can be obtained from the same solution by controlling the crystallization conditions. All two complexes possess a carboxylate‐Im‐cobalt(II) triad system analogous to the carboxylate‐histidine‐metal triad systems that have been found in many zinc enzymes and cobalt(II)‐substituted enzymes. In 2, two Co2+ ions are connected by a water molecule in a bridging fashion with Co°Co [0.3687(1) nm], Co—OH2 [0.2159(3) nm], and Co‐OH2‐Co [117.2(3)°], in which the water molecule is further stabilized by two intramolecular hydrogen bonds with the oxygens of the terminal monodentate acetate groups with the distance of O…0 [0.2609(7) nm]. The terminal monodentate acetate groups display quite abnormal geometry due to the strong “pulling effect” on the carboxylates by intermolecular and intramolecular hydrogen bonds. Complex 2 showed weak antiferromagnetic coupling at low temperature with g = 2.22 and J = −1.60 cm−1.
Cluster‐cracking Reaction, a New Method to Synthesize Unsymmetrical Dithiolate Complexes for the Study of Third‐Order Nonlinear Optical Properties
Authors: Guo‐Qmg Bian , Qin‐Yu Zhu , Xin Wang , Wei Yang , Ze‐Min Yan , Jie Dai , Zhen‐Rong Sun , Megumu Munakata , Masahiko Maekawa
Published: September 2010

A new cluster‐cracking method to synthesize dithiolate metal complexes was reported and four unsymmetric complexes with formula (Me4N)2[M(Ln)(SPh)2] (M = Cd and Zn, L1 = dmit = 1,3‐dithiole‐2‐thione‐4, 5‐dithiolate, L2 = dmid = 1, 3‐dithiole‐2‐one‐4, 5‐dithiolate, SPh= thiophenolate) (1–4) were characterized by elemental analysis, IR, UV NMR spectra and so on. The advantages of this method are summarized in two aspects: (1) the preparation is very convenient; (2) the reaction usually completed giving the product with high purity. The crystal structure of 1 showed that the bond distances of Cd(II) to the sulfur of the thiophenolate group are shorter than those of Cd(II) to the sulfur of dmit, so that the thiophenolate group does not be replaced in the reaction and the mixed ligand complexes are the dominant products. The dmit complexes showed well third‐order NLO properties, but not of the dmid complexes, although dmid is an analogue to dmit.
Synthesis of New Chiral Building Blocks for Novel Peptide Nucleic Acids
Authors: Jie Wu , Xiao‐Yu Xu , Ke‐Liang Liu
Published: September 2010

N‐Boc protected amino acids of analogues of peptide nucleic add (PNA.), which are a class of conformationally constrained building blocks based on 4‐aminoproline backbone with chirality at 2‐C and 4‐C, have been synthesized. Those monomers can be used for the construction of novel peptide nucleic acid analogues.
Lanthanide Complexes for Oligomerization of Phenyl Isocyanate
Authors: Ming‐Yu Deng , Ying‐Ming Yao , Yu‐Fang Zhou , Li‐Fen Zhang , Qi Shen
Published: September 2010

A series of lanthanide complexes including (Ind)3Sm(THF) (1), [(MeCp)2Sm(μ‐SPh)(THF)]2(2), [(MeCp)2Y(μ‐O‐i‐Pr)]2 (3), (MeCp)3Sm·θF (4), Sm(SPh)3(hmpa)3(5), [(MeCp)2Y‐(μ‐OCH2CF3)]2(6) and (OF3CH2O)3 Y(THF)3 (7) were synthesized and they have good activity for the oligomerization of phenyl isocyanate. Among them 5 shows the highest activity. The conversion is as high as 96.2%, with 1/2500 of the molar ratio of cat./ PhNCO. The main components in oligomer were characterized to be a cyclodimer and a cyclotrimer. The ratio of cyclodimer to cyclotrimer depends on the lanthanide complexes used. 7 gave 85.2% cyclotrimer with 1/300 of the molar ratio of cat./PhNCO at 40 °C for 0.5 h, while 5 gave 77.6% cyclodimer with 1/300 of the molar ratio of cat./PhNCO at 40 °C for 4 h.
A New Solution‐phase Parallel Synthesis of 2‐Alkylamino‐3‐aryl‐5‐phenylmethylene‐3,5‐dihydro‐4H‐imidazol‐4‐ones
Authors: Ming‐Wu Ding , Yong Sun , Xiao‐Peng Liu , Zhao‐Jie Liu
Published: September 2010

Thirteen new 2‐alkylaminoimidazolones (4) were rapidly synthesized by a new solution‐phase parallel synthetic method, which includes aza‐Wittig reaction of iminophosphorane (1) with aromatic iso‐cyanate to give carbodi‐imide (2) and subsequent reaction of 2 with various aliphatic primary amine in a parallel fashion. The products were confirmed by 1H NMR, MS, IR and X‐ray crystallographic analysis. The unusual selectivity of the cyclization was probably due to the geometry of the guanidine intermediate.
Synthesis and Crystal Structure of a Novel Supramolecular Compound [Mg(H2O)6](C16H11O4SO3)2·10H2O
Authors: Zun‐Ting Zhang , Bo‐Lun Yang , Qian‐Guang Liu , Xiao‐Hong Liu , Zi‐Wd Gao , Kai‐Bei Yu
Published: September 2010

A hydrolyte of magnesium 7‐methoxyl‐4′‐hydroxylisoflavone‐3′‐sulfonate ([Mg(H2O)6](C16H11O4SO3)2·10H2O) was synthesized and its crystal structure was determined by X‐ray diffraction analyses. The crystal belongs to triclinic crystal system, space group P‐1with cell constantsa= 0.7359(1) nm,b= 0.9935(1) nm,c= 1.6335(2) nm, α = 91.16(1)°, β = 92.07(1)°, γ = 106.53(1)°,V= 1.1436(2) nm5and Z = 1. The results show that the title compound consists of [Mg(H2O)6]2+, C16H11O4SO3‐and H2O. Mg(II) is located at the symmetry center of the title compound. [Mg(H2O)6]2+, C16H11SO3−and H2O form fourteen kinds of hydrogen bonds. The distance of 0.351 nm between parallel isoflavone rings shows a #‐# stacking interaction. The hydrogen bonds and #‐# stacking interaction lead to supramolecular formation with three‐dimensional network structure. The title compound was also characterized by IR and1H NMR spectra.
Unexpected Strong Luminescence of Polysiloxanes Containing Carbazolyl and C60 Moeities as Side Chains
Authors: Zhen Li , Jin‐Gui Qin , Yong Cao , Yu‐Hoa Niu
Published: September 2010

Two types of polysiloxanes, which contain both C60 moieties and carbazolyl groups in the side chains with a difference in the numbers of the reacting site on C60 molecules, were synthesized and their fluorescent properties were studied to distinguish the role of C60 in the luminescent polymers. Our results demonstrated that when C60 moieties are bonded to the polymers as multisubstituents but not linked to the luminescent moieties directly, the luminescence of the resultant polymers were still very strong instead of quenching, even the substituted degree is only 1.01.
Calculations on the Nonlinear Second‐Order Optical Polarizabilities for Series of Donor‐C60 Molecules
Authors: Xiao‐Juan Liu , Ji‐Kang Feng , Ai‐Min Ren , Xin Zhou
Published: September 2010

The equilibrium geometries and UV‐visible spectra of a series of donor‐C60 molecules were obtained by means of the AM1 and INDO/CI method, on the basis of accurate geometric and electronic structures. The nonlinear second‐order optical polarizabilities were calculated using the method INDO/SDCI combined with the Sum‐Over‐States (SOS) expression. The calculated β (λ=1.34μm) values are 28.81, 48.56, 57.33, 66.99, 70.85, 85.84, and 142.14 (× 10–30 esu) for the molecules A, B, C, D, E, F and G, respectively. The frontier orbitals were plot for the representative molecules in order to exhibit the intramolecular charge transfer. The results indicate that introduction of thienylethylene can enhance the NLO response and the dimethylaniline‐substituted dithienyl‐ethylene‐C60(molecule G) possesses the largest NLO second‐order optical polarizability. The large β values can be attributed to the charge transfer between the substituents and C60, as well as within the three‐dimensional conjugated sphere of C60.
Synthesis and Nonlinear Optical Characterization of a New Two‐photon Absorbing Organic Dye: DMAHAS
Authors: Yun‐Xing Yan , Dong Wang , Xian Zhao , Xu‐Tang Tao , Min‐Hua Jiang
Published: September 2010

Trans‐4‐(N, N'‐dimethyl amino)‐4′‐(N‐hydroxyethyl‐N'‐ethyl amino) stilbene (DMAHAS) has been synthesized and characterized by 1H NMR spectra, ER spectra and elemental analysis. Linear absorption, single‐photon induced fluorescence and two‐photon induced fluorescence were experimentally studied. This new dye has a moderate two‐photon absorption cross‐section of σ 2 = 0.91 × 10–46 cm4 · s/photon at 532 nm by using an open aperture Z‐scan technique. The result indicates that DMAHAS shows a strong two‐photon induced blue fluorescence of 432 nm when pumped with 800 nm laser irradiation.
Investigation on the Electrochemical Polymerization of Catechol by Means of Rotating Ring‐disk Electrode
Authors: Yong Kong , Shao‐Lin Müu
Published: September 2010

The electrolysis of catechol was studied in the pH values of 1 to 10. The results from the rotating ring‐disk electrode (RRDE) experiments show that at low pH values, the electrochemical polymerization of catechol was performed by one step, and at higher pH values, the electrochemical polymerization of catechol was carried out by two steps, i.e. oxidation of catechol and followed by polymerization. The intermediates generated at the disk were detected at the ring electrode in the ring potential region of‐0.2to 0 V (vs. Ag/AgCl). One of reasons for the decrease in the ratio of ir to id with increasing the ring potential is caused by formation of positively charged intermediates at the disk electrode. This ratio increases with increasing the rotation rate of the RRDE, which indicates that the intermediates are not stable. A shielding effect during polymerization of catechol was observed when the ring potential was set at 0.1 V (vs. Ag/AgCl). The electron spin resonance (ESR) of polycatechol shows that polycatechol possesses unpaired electrons. The images of polycatechol films synthesized at different conditions are described.
Structure and Photosynthetic Mimicking of Bis (2,6‐bis (benzimidazol‐2‐yl) pyridine) manganese (II)
Authors: Wei Shi , Wei Li , Ying‐Kai Xu , Hong‐Mei Wang , Mei Shi , Yang Liu , Ping‐Ping Shen
Published: September 2010

Mn(bzimpy)2(1) [bzimpy = 2, 6‐bis (benzimidazol‐2‐yl) pyridine], a mononuclear manganese (IT) complex, was synthesized by the reaction of Mn (OOCMe)2 with bzimpy in absolute ethanol. The complex was structurally characterized by elemental analysis, cyclic voltammetry, and X‐ray crystallography. In the complex, the manganese‐nitrogen distances were different, and the geometry and the metal ion environment showed the distortion. The cyclic voltammetric measurements have been performed to assess its redox characteristics. The presence of oxidation wave at + 0.62 V and + 0.81 V vs. SCE or + 0.8 V and + 1.0 V vs. NHE suggested that this complex could catalyze the oxidation of water, therefore, simulate the water‐oxidizing complex (WOC) of photosystem II (PS II). The measurements of photoreduction of 2, 6‐dichlorophenolindophenol (DCPIP), and oxygen evolution in the manganese‐depleted and the complex 1‐reconstituted PS II preparations just support our conjecture.
Fabrication, Characterization and Electrocatalysis of an Ordered Carbon Nanotube Electrode
Authors: Jing Chen , Jian‐Chun Bao , Chen‐Xin Cai
Published: September 2010

A method for fabrication of the ordered carbon nanotube (CNT) film, which was template‐synthesized within the highly ordered pores of a commercially available alumina template membrane, modified glassy carbon (CNT/GC) electrode was established. The CNT/GC electrode showed excellent electro‐catalytic activity toward dopamine electrochemical reaction without introducing any electrochemically active group into CNT film or activating the electrode electrochemically. DA undergoes ideal reversible electrochemical reaction on CNT/GC electrode at low scan rate (≤20 mV/s) with an excellent reproducibility and stability. The CNT/GC electrode might be used in biosensors because the highly ordered CNT may present a steric effect on more efficient redox reactions of biomolecules.
Clean Synthesis in Water: Darzens Condensation Reaction of Aromatic Aldehydes with Phenacyl Chloride
Authors: Da‐Qing Shi , Shu Zhang , Qi‐Ya Zhuang , Xiang‐Shan Wang , Shu‐Jiang Tu , Hong‐Wen Hu
Published: September 2010

The Darzens condensation reaction of aromatic aldehydes with phenacyl chloride proceeded very efficiently in a water suspension medium in the presence of triethylbenzylammonium chloride and only trans‐2, 3‐epoxy‐l, 3‐diaryl‐l‐propanones were formed which can be isolated simply by filtration. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectra. Their configurations are in agreement with that of the same compounds reported in the literature. Compared to the classical Darzens condensation, this new method has the advantages of good yields, high stereoselectivity, low running cost inexpensive and environmentally benign procedure.
Anodic Stripping Voltammetric Determination of Lead (II) Using Glassy Carbon Electrode Modified with Novel Calix[4]arene
Authors: Jian‐Quan Lüu , Xi‐Wen He , Xian‐Shun Zeng , Hai‐Li Zhang , Zheng‐Zhi Zhang
Published: September 2010

A new glassy carbon electrode modified with novel calix[4]‐arene derivative was prepared and then applied to the selective recognition of lead ion in aqueous media by cyclic and square wave voltammetry. A new anodic stripping peak at − 0.92 V (vs. Ag/Ag+) in square wave voltammogram can be obtained by scanning the potential from − 1.5 to − 0.6 V, of which the peak current is proportional to the concentration of Pb2+. The modified electrode in 0.1 mol/L HNO3 solution showed a linear voltammetric response in the range of 2.0 × 10–8–1.0 × 10–6 mol/L and a detection limit of 6.1 × 10–9 mol/L. In the modified glassy carbon electrode no significant interference occurred from alkali, alkaline and transition metal ions except Hg2+, Ag+ and Cu2+ ions, which can be eliminated by the addition of KSCN. The proposed method was successfully applied to determine lead in aqueous samples.
Synthesis of Dendritic Schiff Base Ligands for Titanium Catalyzed Enantioselective HDA Reaction of Danishelfsky's Diene with Aldehydes
Authors: Ji Bao‐Ming , Ding Kui‐Ling , Meng Ji‐Ben
Published: September 2010

A new type of dendritic NOBIN derived Schiff base ligands has been synthesized and applied to titanium catalyzed hetero‐Diels‐Alder reaction of Danishelfsky's diene and aldehydes, affording the corresponding 2‐substituted 2,3‐dihydro‐4H‐pyran‐4‐one in good yields and moderate enantioselectivities (up to 59.2% ee). It was found that the size of dendron attached to the tri‐dentated ligands has slight impact on the enantioselectivity of the reaction and the second generation of dendritic ligand exhibited the best enantioselectivity.
Study on the Aggregation and Deaggregation Behaviors of Phosphatidylcholines
Authors: Ji Guo‐Zhen , Long Ya‐Qiu , Jiang Xi‐Kui
Published: September 2010

Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatidylcholines (Ln) and their analogues 1, 2‐diacyl‐sn‐glycerol‐3‐phosphoric acid bromoethyl ester (Pn), have been investigated in MeOH‐H2O binary systems of different volume fractions (designated as ϕ) of the organic component, by employing α‐nephthylethyl lauryl ether (Np‐12) as fluorescent probe. A very interesting observation is that the Ln possesses double character, i.e., it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deaggregation are also discussed.