bluuebunny/crossref_metadata_2025 huggingface dataset:
Fuzzy-Based Intelligent Model for Rapid Rock Slope Stability Analysis Using Qslope
Authors: Mao Yimin , Chen Liang , Nanehkaran Yaser A. , Azarafza Mohammad , Derakhshani Reza
Published: August 2023

Artificial intelligence (AI) applications have introduced transformative possibilities within geohazard analysis, particularly concerning the assessment of rock slope instabilities. This study delves into the amalgamation of AI and empirical techniques to attain highly precise outcomes in the evaluation of slope stability. Specifically, our primary objective is to propose innovative and efficient methods by investigating the integration of AI within the well-regarded Qslope system, renowned for its efficacy in analyzing rock slope stability. Given the complexities inherent in rock characteristics, particularly in coastal regions, the Qslope system necessitates adjustments and harmonization with other geomechanical methodologies. Uncertainties prevalent in rock engineering, compounded by water-related factors, warrant meticulous consideration during all calculations. To address these complexities, we present a novel approach through the infusion of fuzzy set theory into the Qslope classification, leveraging fuzziness to effectively quantify and accommodate uncertainties. Our approach employs a sophisticated fuzzy algorithm encompassing six inputs, three outputs, and 756 fuzzy rules, thereby enabling a robust assessment of rock slope stability in coastal regions. The implementation of this method capitalizes on the high-level programming language Python, enhancing computational efficiency. To validate the potency of our AI-based approach, we conducted preliminary tests on slope instabilities within coastal zones, indicating a promising initial direction. The results underwent thorough evaluation, affirming the precision and dependability of the proposed method. However, it is crucial to emphasize that this work represents a first attempt to apply AI to the evaluation of rock slope stability. Our findings underscore a high degree of concurrence and expeditious stability assessment, vital for timely and effective hazard mitigation. Nonetheless, we acknowledge that the reliability of this innovative method must be established through broader applications across diverse scenarios. The proposed AI-based approach’s effectiveness is validated through a preliminary survey on a slope instability case within a coastal region, and its potential merits must be substantiated through broader validation efforts.
Protecting Built Heritage against Flood: Mapping Value Density on Flood Hazard Maps
Authors: Brokerhof Agnes W. , van Leijen Renate , Gersonius Berry
Published: August 2023

This paper describes the development and trial of a method (Quick Flood Risk Scan method) to determine the vulnerable value of monuments for flood risk assessment. It was developed in the context of the European Flood Directive for the Dutch Flood Risk Management Plan. The assessment method enables differentiation of cultural heritage by cultural value and vulnerability to water from rainfall or flooding. With this method, hazard or exposure maps can be turned into risk maps showing the potential loss of cultural value in case of flooding with a particular probability. The Quick Flood Risk Scan method has been tested and validated in the City of Dordrecht, the Netherlands. This application was facilitated by an Open Lab of the SHELTER project. The trial in Dordrecht showed the potential of a simple method to prioritize monuments without calculations. The Quick Flood Risk Scan method enables even the non-expert assessor to make a preliminary qualitative assessment that can be followed by further analysis of a relevant selection of assets. It is useful as a low tier that feeds into higher tiers of a multi-level framework. The non-expert assessor may be a policy maker, an owner of a heritage asset, or an inhabitant. Nonetheless, the trial also raised several questions, ranging from where in a building valuable heritage is located and what the role of the building owner is to how policy makers implement the method and its outcomes. These questions provide relevant input for fine-tuning the method.
Seepage and Heat Transfer of Dominant Flow in Fractured Geothermal Reservoirs: A Review and Outlook
Authors: Liu Zhiyan , Liu Yanguang , Li Tingxin , Wei Meihua
Published: August 2023

Deep geothermal reservoirs have great potential for exploitation and are characterized by high temperatures, high stress, and strong heterogeneity. However, these reservoirs contain widely and continuously distributed dominant flow channels with high permeability, predisposing these reservoirs to the formation of dominant flow, which notably decreases the efficiency of heat extraction. Focusing on the dominant flow in fractures, this study provides a definite concept, systematically reviews current studies, and puts forward suggestions for future research. It is expected that this study will serve as a reference for the sustainable, high-quality development of deep geothermal resources.
Phototropic Behavioral Responses of Zooplankton in Lake Baikal In Situ and during the Anthropogenic Impact Modeling
Authors: Dyomin Victor , Morgalev Yuri , Polovtsev Igor , Morgalev Sergey , Morgaleva Tamara , Davydova Alexandra , Kondratova Oksana
Published: August 2023

Earlier, we showed that the registration of the behavioral responses of autochthonous mesozooplankton communities in situ is a more dynamic methodological approach in the biological assessment of the environmental well-being of aquatic ecosystems, as well as an alternative method to generally accepted tests on mortality and immobilization. The change in behavioral responses, including phototropic responses, may occur at lower concentrations of pollutants, leading to the inhibition of the risk-avoidance response of predatory fish attack and, ultimately, to the change in zooplankton abundance and biodiversity. The biological significance of such changes is quite high since zooplankters form the basis of food chains. This work studies the possibility of biomonitoring the quality of fresh water in Lake Baikal according to the state of the autochthonous mesozooplankton community in summer and winter using a digital holographic camera developed and tested by us in laboratory conditions. This method makes it possible to determine the concentration of plankters in the controlled volume of the DHC and perform photostimulation with different levels of illuminance. The depth profilometry of the phototropic response was compared with the profilometry of plankton concentration, intraspecific diversity of crustaceans according to the Pielou index, and the results of catching using the Juday net in the natural environment of the lake and during the modeling of the anthropogenic impact (introduction of table salt solution into the local area close to the registration probe). The circadian rhythm parameters were determined by the spectral analysis of the long-term registration of the phototropic response dynamics. It was noted that the inhibition of the phototropic response was the most adequate marker of the exogenous impact and the appearance of an alternating factor among the studied indicators of the state of the plankton community, namely, intraspecific diversity, synchronism of circadian rhythms, and response to paired photostimulation. The revealed patterns of behavioral responses of autochthonous zooplankton in natural and artificially modified conditions will allow for the implementation of long-term continuous control over the environmental well-being of water areas, including the collection ponds of treatment facilities, cooling ponds of nuclear power plants, and other water areas in contact with potentially hazardous facilities. The comparison of the identified patterns with the behavioral responses of euryhaline mesozooplankton will expand this method to assess the well-being of salt-water and marine reservoirs under the anthropogenic impact and will make it possible to create a continuous monitoring system.
Biochar/Clay Composite Particle Immobilized Compound Bacteria: Preparation, Collaborative Degradation Performance and Environmental Tolerance
Authors: Sun Pengfei , Wei Jun , Gao Yaoyao , Zhu Zuhao , Huang Xiao
Published: August 2023

Immobilized microbial materials can effectively remove pollutants from surface water, and a biochar/clay composite particle (BCCP) material is prepared with immobilized Flavobacterium mizutaii sp. and Aquamicrobium sp. to remove ammonia nitrogen (NH4+–N) and petroleum hydrocarbons (PHCs). The results indicated that the optimal ratios of biochar, Na2SiO3 and NaHCO3 were 15%, 3%, and 3%, and the adsorption process was found to be better described with the pseudo-second-order kinetic equation. The individual immobilization of Flavobacterium mizutaii sp. and Aquamicrobium sp. with sodium alginate–polyvinyl alcohol (PVA + SA) achieved 80% and 90% removal efficiencies for NH4+–N and PHCs at the 10th d. The composite immobilization of two efficient bacteria could degrade 82.48% NH4+–N and 74.62% PHCs. In addition, immobilization relieved the effects of temperature and salinity. This study can provide guidance for the application of immobilized microbial composite materials in natural water environments.
DETERMINATION OF RESIDUAL DEFLECTIONS OF BENT REINFORCED CONCRETE ELEMENTS BASED ON A NONLINEAR DEFORMATION MODEL
Authors: Shevchenko A. , Baglaev N. , Zelenev E. , Kurbatov V.
Published: August 2023

The purpose of this work is to numerically implement the determination of residual deflections of reinforced concrete elements based on a nonlinear deformation model. To solve the equations in a physically nonlinear formulation, the iteration method is used in combination with Microsoft Excel and VBA. Most of the existing engineering methods for the verification calculation and reinforcement of bent elements are based on approaches based on the determination of integral stiffness characteristics of the section by simplified methods. This problem acquires new relevance when using the current norms, when it is necessary to take into account the features of nonlinear deformation of materials, loading mode, and the background of the structure. The article considers the application of a nonlinear deformation model in the calculation of residual deflections. To solve this problem, the bent element is divided into separate sections, on each of which stiffness is calculated based on a nonlinear deformation model. When solving systems of equilibrium equations of a nonlinear deformation model, the iteration method is used. In areas with cracks, the stresses in the reinforcement are adjusted by a coefficient that takes into account the unevenness of their distribution in the section with the crack and between them. After determining the stiffness coefficients in each section, the displacement is determined by integrating the values in the sections of unit moments and the calculated curvature by the numerical method of trapezoids. A load-deflection graph is constructed and approximated by a square polynomial with the derivation of an analytical dependence to determine the residual deflections as well as the stress-strain state of the bent elements as a whole. The analysis and comparison of the results with the normative methodology is given. Numerical example of calculation of good convergence with the normative methodology
THE EFFECT OF MICRO-FILLERS ON THE EFFECTIVENESS OF SUPERPLASTICIZERS AND THE STRENGTH OF LOW-CEMENT CONCRETES
Authors: Tolypina N. , Hahaleva E. , Danilov D. , Chashin D.
Published: August 2023

In concretes of ordinary grades with a cement consumption of 180–250 kg/m3, the reduction in the water demand of the concrete mixture, even with the maximum consumption of superplasticizers, does not exceed 10 %. In this regard, the influence of micro-fillers with various electrosurface properties on the effectiveness of the superplasticizer and the strength of low-cement concrete is investigated.

It is shown that in the concrete mixture of the control composition, achieving a normal consistency (PK = 106–115 mm) is possible only due to high water consumption, the water-reducing efficiency of the joint venture was only 4,5 %. It was found that with the addition of fine quartz from 20 to 70 %, the consumption of the powder part increased from 230 to 452 kg/m3, while there was a decrease in W / C from 0,68 to 0,51 (33 %), as well as an increase in strength by 40,5 % (R7comp) and 30,6 % (R28 comp). With an increase in the dosage of limestone microfillers from 20 to 70 % W / C decreased from 0,66 to 0,5 (32 %), the strength increased by 145 % (R7 comp) and 74% (R28 comp). Thus, the use of fine-dispersed fillers in low-cement concretes makes it possible to achieve a significant reduction in W/C by 23,6–43,8 % in equally mobile mixtures (GOST 310.4), depending on the dosage of the powder filler (20–70 %), while the type of filler does not have a noticeable effect on the water-reducing ability of the superplasticizer, but plays a significant role in the processes of structure formation of cement concrete matrices, due to the influence of their electrosurface properties on the adhesion between filler particles and cement stone. In low-cement concretes, with the growth of fine fillers from 20 to 70 %, the strength of concrete increases.
PREREQUISITES FOR FORMING THE ARCHITECTURE OF TEMPORARY HOUSINGS FOR ZONES OF EMERGENCY SITUATIONS IN THE RUSSIAN FEDERATION
Authors: Dolzhenko A.
Published: August 2023

The article examines the role of temporary shelters in recovery programs for emergency zones of the Russian Federation. The frequency of natural disasters and emergencies is analyzed, as well as a number of problems associated with the need to resettle the affected population in the existing housing stock of settlements located in territories adjacent to the emergency zone or resettlement of the affected to other regions.

The features of the use of temporary accommodation centers, both stationary and mobile, the possible duration of their use are considered, the provision of the regions of the Russian Federation with them is analyzed. A review of existing research works and developed solutions for mobile housing for temporary stay is carried out on the example of domestic and foreign works.

The relevance of further research in the issue of determining common problems, patterns and technical solutions in the formation of temporary dwellings for emergency zones of the Russian Federation in the context of further development of principles is substantiated. Goals, boundaries, novelty, tasks of further research are highlighted. For the first time, the question of the possibility of using transforming mobile buildings from rigid elements as temporary housing for emergency zones in the Russian Federation is raised as part of a general study on the formation of principles.
Bokbål och höjda hyror
Authors: Kriström Olov
Published: August 2023

Essay
The influence of evolutionary processes of consciousness on the performance expressiveness of a musical work
Authors: Діте Людмила Анатоліївна
Published: August 2023

The purpose of the article. Based on the philosophical, musicological, psychological and pedagogical literature, to reveal the dependence of expressiveness in the performance of musical works on the evolutionary patterns of development of musical art, consciousness and spiritual outlook of the performer himself.
The methods and methodology are based on the analysis and systematization of scientific information on the evolutionary processes taking place in the world, musical art and their impact on the consciousness of the performing musician and his/her performance skills.
The scientific novelty of the article lies in the fact that the dependence of the expressiveness of the performing musician, the sound of the musical work on his own spiritual substance is determined on the basis of philosophical concepts.
Results. The article deals with the problems of musical performance, certain regularities
in the presentation of musical works formed by different performing eras, which affirmed a far from unambiguous vision of the essence of the performer’s expressiveness. It is emphasized that the evolutionary processes taking place in human consciousness naturally affect the evolution of composer’s thinking and the expressiveness of a musician’s performance. It is revealed that in the conditions of modernity, when the idea of human nature is changing, which is considered more as a vibrational entity than as a physical one, new facets of understanding are introduced into the understanding of performing expressiveness.
It is noted that by reaching the level of high-frequency vibrations, the performer is already able to reflect the synthesis of two worlds - manifested and unmanifested, getting the opportunity to reveal personal expressiveness as an external manifestation of the expression of the soul.
The significance of musical intonation is emphasized, which is the highest manifestation of the expressiveness of musical performance, reveals the ontological image of the musician. Thus, given that the musical sound is generated by the spiritual basis of the existence of its performer, it is important to achieve one’s own depth in the embodiment of sound.
Моделювання професійно-орієнтованих завдань засобами інноваційних форм підготовки майбутнього вчителя музичного мистецтва
Authors: Беземчук Лариса , Фомін Володимир
Published: August 2023

Метою статті є висвітлення впливу інноваційних форм на підготовку майбутнього вчителя музичного мистецтва в процесі навчання в магістратурі. В контексті дослідження були використані методи: теоретичного аналізу мистецтвознавчої, методичної та педагогічної літератури; моделювання змісту музичної освіти та інші. Аналіз типу педагогічного мислення є базовим для студентів-магістрантів й охоплює оперативне мислення через жваве сприйняття найкращих методичних рішень, відходження від звичних стереотипів професійної діяльності через гнучке мислення, творче експериментування та новаторство, урахування можливостей моделювання сучасного уроку та передбачуваних результатів тощо.У ході дослідження було теоретично обґрунтовано значущість професійно-орієнтованих завдань в контексті вирішення питань професійної підготовки майбутнього вчителя музичного мистецтва в умовах здобуття другого освітнього рівня вищої освіти. Визначено, що проектування освітніх програм для студентів за спеціальністю 014 Середня освіта (Музичне мистецтво) орієнтує здобувачів другого магістерського рівня на формування особливого типу поліфонічного мислення. Доведено, що такий тип мислення є пріоритетним для вирішення професійно-орієнтованих завдань на заняттях «Методика викладання дисциплін кваліфікації», «Практикум за кваліфікацією», «Методика викладання інтегрованого курсу мистецтва в ЗОШ». Виділено етапність моделювання професійно-орієнтованих завдань: попередній етап впливає на хід наступного (метод перспективи та ретроспективи); вирішення складних ситуацій (метод емпатії, співпереживання); обов’язкова спільна діяльність учасників (метод комунікативного пошуку); опис психолого-педагогічної ситуації (метод конструювання змісту компонентів музичної освіти, кейс-метод) та об’єкта ігрового імітаційного моделювання (метод спостереження); контроль ігрового часу (метод фіксації); заздалегідь розроблена система аналізу та оцінок (метод рефлексії); особливості сприймання та аналізу мистецьких явищ (метод художньо-творчого аналізу); елементи художньо-творчого змагання (метод творчого діалогу).
Cloth-based microfluidic devices integrated onto the patch as wearable colorimetric sensors for simultaneous sweat analysis
Authors: Kuswandi Bambang , Irsyad Lukman H , Puspaningtyas Ayik R.
Published: August 2023

Introduction: In this work, a flexible, and wearable point-of-care (POC) device integrated on a pain relief patch as wearable colorimetric sensors have been developed for sweat analysis, such as lactic acid, sodium ions, and pH simultaneously. Herein, the patch has still functioned as pain relief, while it allows for sweat monitoring during exercise, and in daily activities. Methods: It was constructed on cotton cloth using wax printing technology (batik stamp) as cloth-based microfluidic devices (CMDs). Here, it uses micro volumes of samples to perform the reaction in the sensing zones, where the sensitive reagents are immobilized so that it can collect and analyze the sweat (lactic acid, sodium ions, and pH) as the model for sweat analytes. The colorimetric analysis was conducted via a smartphone camera by using a free app (Color Grab) for a color image analysis that uses for quantitative analysis or naked eye for semi-qualitative analysis. Results: The ∆RGB value of the CMDS shows the excellent linear correlation vs analytes concentration, where the coefficient of correlations was found for lactic acid (R2 = 0.994), sodium ion (R2 = 0.998), and pH (R2 = 0.994). The ∆RGB value shows the appropriate color value for the linear correlation of the analyte target concentrations in the sweat samples. Here, the limit of detection (LOD) was found at 45.73 µg/mL for lactic acid and 56.46 µg/mL for sodium ions. The reproducibility was found at 0.79% and 0.89%, for lactic acid and sodium ions respectively.
Preparation and evaluation of a polycaprolactone/chitosan/propolis fibrous nanocomposite scaffold as a tissue engineering skin substitute
Authors: Hashemi Seyedeh-Sara , Mohammadi Ali Akbar , Rajabi Seyedeh-Somayeh , Sanati Parisa , Rafati Alireza , Kian Mehdi , Zarei Zahra
Published: August 2023

Introduction: Recently, the application of nanofibrous mats for dressing skin wounds has received great attention. In this study, we aimed to fabricate and characterize an electrospun nanofibrous mat containing polycaprolactone (PCL), chitosan (CTS), and propolis for use as a tissue-engineered skin substitute. Methods: Raw propolis was extracted, and its phenolic and flavonoid contents were measured. The physiochemical and biological properties of the fabricated mats, including PCL, PCL/CTS, and PCL/CTS/Propolis were evaluated by scanning electron microscopy (SEM), atomic force microscopy (AFM), mechanical analysis, swelling and degradation behaviors, contact angle measurement, cell attachment, DAPI staining, and MTT assay. On the other hand, the drug release pattern of propolis from the PCL/CTS/Propolis scaffold was determined. A deep second-degree burn wound model was induced in rats to investigate wound healing using macroscopical and histopathological evaluations. Results: The results revealed that the propolis extract contained high amounts of phenolic and flavonoid compounds. The fabricated scaffold had suitable physicochemical and mechanical properties. Uniform, bead-free, and well-branched fibers were observed in SEM images of mats. AFM analysis indicated that the addition of CTS and propolis to PCL elevated the surface roughness. MTT results revealed that the electrospun PCL/CTS/Propolis mat was biocompatible. The presence of fibroblast cells on the PCL/CTS/Propolis mats was confirmed by DAPI staining and SEM images. Also, propolis was sustainably released from the PCL/CTS/Propolis mat. The animal study revealed that addition of propolis significantly improved wound healing. Conclusion: The nanofibrous PCL/CTS/Propolis mat can be applied as a tissue-engineered skin substitute for healing cutaneous wounds, such as burn wounds.
Epithelial cells/progenitor cells in developing human lower respiratory tract: Characterization and transplantation to rat model of pulmonary injury
Authors: Ganji Fatemeh , Ebrahimi Marzieh , Shirani Ali , Golmohammadi Mahtab , Gholipourmalekabadi Mazaher , Kashanian Maryam , Koolaeinezhad Kiana , Davari Hamid Reza , Mousavi Seyed Ali Javad , Aghayan Hamid Reza , Arjmand Babak , Heshmat Ramin , Karkuki Osguei Nushin , Samadikuchaksaraei Ali
Published: August 2023

Introduction: For cell-based therapies of lung injury, several cell sources have been extensively studied. However, the potential of human fetal respiratory cells has not been systematically explored for this purpose. Here, we hypothesize that these cells could be one of the top sources and hence, we extensively updated the definition of their phenotype. Methods: Human fetal lower respiratory tissues from pseudoglandular and canalicular stages and their isolated epithelial cells were evaluated by immunostaining, electron microscopy, flow cytometry, organoid assay, and gene expression studies. The regenerative potential of the isolated cells has been evaluated in a rat model of bleomycin-induced pulmonary injury by tracheal instillation on days 0 and 14 after injury and harvest of the lungs on day 28. Results: We determined the relative and temporal, and spatial pattern of expression of markers of basal (KRT5, KRT14, TRP63), non-basal (AQP3 and pro-SFTPC), and early progenitor (NKX2.1, SOX2, SOX9) cells. Also, we showed the potential of respiratory-derived cells to contribute to in vitro formation of alveolar and airway-like structures in organoids. Cell therapy decreased fibrosis formation in rat lungs and improved the alveolar structures. It also upregulated the expression of IL-10 (up to 17.22 folds) and surfactant protein C (up to 2.71 folds) and downregulated the expression of TGF-β (up to 5.89 folds) and AQP5 (up to 3.28 folds). Conclusion: We provide substantial evidence that human fetal respiratory tract cells can improve the regenerative process after lung injury. Also, our extensive characterization provides an updated phenotypic profile of these cells.
Protective effects of limb remote ischemic per-conditioning on the heart injury induced by renal ischemic-reperfusion through the interaction of the apelin with the RAS/iNOS pathway
Authors: Janfeshan Sahar , Masjedi Fatemeh , Karimi Zeinab
Published: August 2023

Introduction: Remote ischemic conditioning upregulates endogenous protective pathways in response to ischemia-reperfusion injury. This study tested the hypothesis that limb remote ischemic per-conditioning (RIPerC) exerts cardioprotective effects via the renin-angiotensin system (RAS)/inducible nitric oxide synthase (iNOS)/apelin pathway. Methods: Renal ischemia-reperfusion injury (I/R) was induced by bilateral occlusion of the renal pellicles for 60 minutes, followed by 24 hours of reperfusion; sham-operated rats served as controls. RIPerC was induced by four cycles (5 minutes) of limb ischemia-reperfusion along with bilateral renal ischemia. The functional disturbance was evaluated by renal (BUN and creatinine) and cardiac (troponin I and lactate dehydrogenase) injury biomarkers. Results: Renal I/R injury increased renal and cardiac injury biomarkers that were reduced in the RIPerC group. Histopathological findings of the kidney and heart were also suggestive of amelioration injury-induced changes in the RIPerC group. Assessment of cardiac electrophysiology revealed that RIPerC ameliorated the decline in P wave duration without significantly affecting other cardiac electrophysiological changes. Further, renal I/R injury increased the plasma (322.40±34.01 IU/L), renal (8.27±1.10 mIU/mg of Protein), and cardiac (68.28±10.28 mIU/mg of Protein) angiotensin-converting enzyme (ACE) activities in association with elevations in the plasma and urine nitrite (25.47±2.01 & 16.62±3.05 μmol/L) and nitrate (15.47±1.33 & 5.01±0.96 μmol/L) levels; these changes were reversed by RIPerC. Further, renal ischemia-reperfusion injury significantly (P=0.047) decreased the renal (but not cardiac) apelin mRNA expression, while renal and cardiac ACE2 (P<0.05) and iNOS (P=0.043) mRNA expressions were significantly increased compared to the sham group; these effects were largely reversed by RIPerC. Conclusion: Our results indicated that RIPerC protects the heart against renal ischemia-reperfusion injury, likely via interaction of the apelin with the RAS/iNOS pathway.
A novel imidazo[1,2-a]pyridine derivative and its co-administration with curcumin exert anti-inflammatory effects by modulating the STAT3/NF-κB/iNOS/COX-2 signaling pathway in breast and ovarian cancer cell lines
Authors: Afshari Havva , Noori Shokoofe , Daraei Azam , Azami Movahed Mahsa , Zarghi Afshin
Published: August 2023

Imidazo[1,2-a]pyridine derivatives with diverse pharmacological properties and Curcumin, as a potential natural anti-inflammatory compound, are promising compounds for cancer treatment. This study aimed to synthesize a novel imidazo[1,2-a]pyridine derivative, (MIA), and evaluate its anti-inflammatory activity and effects on nuclear factor-kB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways, and their target genes, alone and in combination with curcumin, in MDA-MB-231 and SKOV3 cell lines. Methods: We evaluated the interaction between imidazo[1,2-a]pyridine ligand, curcumin, and NF-κB p50 protein using the molecular docking studies. MTT assay was used to investigate the impacts of compounds on cell viability. To evaluate the NF-κB DNA binding activity and the level of inflammatory cytokines in response to the compounds, ELISA-based methods were performed. In addition, quantitative polymerase chain reaction (qPCR) and western blotting were carried out to analyze the expression of genes and investigate NF-κB and STAT3 signaling pathways. Results: Molecular docking studies showed that MIA docked into the NF-κB p50 subunit, and curcumin augmented its binding. The MTT assay results indicated that MIA and its combination with curcumin reduced cell viability. According to the results of the ELISA-based methods, MIA lowered the levels of inflammatory cytokines and suppressed NF-κB activity. In addition, real-time PCR and Griess test results showed that the expression of cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) genes, and nitrite production were reduced by MIA. Furthermore, the western blotting analysis demonstrated that MIA increased the expression of inhibitory κB (IκBα) and B-cell lymphoma 2 (Bcl-2)-associated X proteins (BAX), and suppressed the STAT3 phosphorylation, and Bcl-2 expression. Our findings revealed that curcumin had a potentiating role and enhanced all the anti-inflammatory effects of MIA. Conclusion: This study indicated that the anti-inflammatory activity of MIA is exerted by suppressing the NF-κB and STAT3 signaling pathways in MDA-MB-231 and SKOV3 cancer cell lines.
Inhibitory effect of miR342 on the progression of triple-negative breast cancer cells in vitro and in the mice model
Authors: Alidoost Zahra , Attari Farnoosh , Saadatpour Fatemeh , Arefian Ehsan
Published: August 2023

Introduction: Breast cancer is the most common cancer in women worldwide, and the triple-negative subtype is the most invasive, with limited therapeutic options. Since miRNAs are involved in many cellular processes, they harbor great value for cancer treatment. Therefore, in this study, we have investigated the anti-proliferative and anti-invasive roles of miR342 in 4T1 triple-negative cells in vitro and also studied the effect of this miRNA on tumor progression and the expression of its target genes in vivo. Methods: 4T1 cells were transduced with conditioned media of miR342-transfected Hek-LentiX cells. MTT and clonogenic assays were used to assess the viability and colony-forming ability of 4T1 cells. Apoptosis and invasion rates were respectively evaluated by annexin/7-AAD and wound healing assays. At last, in vivo tumor progression was evaluated using H&E staining, Real-time PCR, and immunohistochemistry. Results: The viability of transduced-4T1 cells reduced significantly 48 hours after cell seeding and colony forming ability of these cells reduced to 50% of the control group. Also, miR342 imposed apoptotic and anti-invasive influence on these cells in vitro. A 30-day follow-up of the breast tumor in the mice model certified significant growth suppression along with reduced mitotic index and tumor grade in the treatment group. Moreover, decreased expression of Bcl2l1, Mcl1, and ID4, as miR342 target genes, was observed, accompanied by reduced expression of VEGF and Bcl2/Bax ratio at the protein level. Conclusions: To conclude, our data support the idea that miR342 might be a potential therapeutic target for the treatment of TNBC.
Direct Medical Expenses of Cancer Patients Undergoing Surgery in Ahvaz Teaching Hospitals
Authors: Bashiri Faezeh , Amraei Mahdi , Faraji-Khiavi Farzad
Published: August 2023

Background. Cancers are showing a rising trend in developing countries. In Iran, cancer is the third leading cause of death after cardiovascular diseases and accidents. The cost of cancer diagnosis and treatment places heavy financial burden on health systems, requiring accurate financial assessments and evaluations. Therefore, this study aimed to determine the direct medical expenses of cancer patients undergoing surgery in Ahvaz, Iran, teaching hospitals. Methods. This descriptive-analytical cross-sectional study was conducted in 2021. The research population included cancer patients undergoing surgery in Ahvaz teaching hospitals. Data collection was done using clinical records of the hospital. Quantitative statistical indicators such as frequency, mean, standard deviation, and tables were used for data analysis. In addition, analytical statistical indicators such as independent samples t-test, one-way analysis of variance (ANOVA), Pearson correlation coefficient, and regression were used with SPSS22 software. Results. The overall mean costs for cancer surgery were calculated at 77,994,903 (SD= 111,224,332) Iranian Rials (IRR). The most expensive cancer surgery was colorectal cancer with an average of 193,558,434 (SD= 266,162,757) IRR, and the lowest cost was pancreatic cancer surgery with an average of 29,284,226 (SD= 23,057,425) IRR. There was a significant positive relationship between the type of cancer (p= 0.000) and the length of hospital stay (p= 0.041) and the cost of hospitalized patients. Conclusion. The economic costs of treating all types of cancer are very high. Any therapeutic and administrative measure that can reduce the cost of cancer treatment or the duration of treatment will contribute significantly to reducing patients' sufferings, improving their quality of life, and reducing the imposed costs.
Efficacy of the intervention based on the self-silencing model in reducing depression and increasing self-expression in women with depression symptoms
Authors: Eydi Khatibi Roghayeh , Khanjani Zeynab , Babapour Jalil , Bakhshipour Rudsari Abbas , Mahmoud Alilou Majid
Published: August 2023

Background. The purpose of this study was to investigate the effectiveness of the self-silencing model in reducing depression and increasing self-expression of depressed women. The self-silencing model is influenced by cognitive, attachment, and gestalt theories, and the role of social and cultural factors is emphasized in it, and these factors lead to depression in women by creating obstacles in expressing their wishes, opinions, and desires. Methods. This was a quasi-experimental study with a pre-test and post-test design with a control group and with random replacement. In this study, using the study of treatment protocols, as well as receiving guidance from the theorists of this model and their colleagues, intervention programs based on it were prepared. The sample of this study included 30 femle teachers from 20 to 40 years old with bachelor's degrees who had depressive symptoms based on the results of The Beck questionnaire and clinical interview. Thus, the research sample included the self-silencing group and the control group, which were obtained from each pre-test and post-test group using the self-expression questionnaire and The Beck questionnaire. Between pre-test and post-test, experimental group received an intervention program. Finally, the scores obtained from pre-test and post-test were analyzed by analysis of covariance using SPSS software. Results. The results of data analysis showed that the intervention based on self-silencing is effective in reducing the depression of the experimental group. Likewise, this intervention method increased self-expression in the experimental group. No significant change was observed in the control group. Conclusion. According to the findings of this research, it can be said that using the self-silencing model can be an efficient method in reducing women's depression symptoms and increasing self-expression in them. Practical Implications. Psychotherapists can use the self-silencing model as one of the effective methods to reduce the symptoms of depression.
Optimalisasi Penyusunan Materi Pelatihan dan Pengembangan di PT. Mitra Akademi Perkasa
Authors: Tunru Axl Alexander , Ananda Denta Felli , Purbasari RR. Niken , Agung Triandewo Maris
Published: August 2023

This internship report aims to explain the author's activities during the internship at PT. Mitra Akademi Perkasa (MAP Retail Academy) through the Magang Bersertifikat Kampus Merdeka (MBKM) Program organized by the Ministry of Education. This program is held to improve abilities and skills, so that they are in accordance with the needs of the world of work in the future. This report will explain about the company, the daily activities of the Author as part of the training and development team and how the work is divided. In addition to daily activities regarding the work provided, this report will explain other activities such as project that provided by PT. Mitra Akademi Perkasa.The results of the program that has been carried out for four and a half months are felt to be effective and efficient. Because in less than 5 months the author gain valuable experience and can fully contribute to the work done, especially in the field of human resources
Kontribusi Talent Acquisition Di Hashmicro Dalam Program MBKM Periode 2022
Authors: Yunius Yunius , Ghazi Muhammad , Wahyudi Agustinus Sri , Widayati Nurti
Published: August 2023

This internship report was prepared to explain the author's experience in participating in the Independent Learning-Independent Campus (MBKM) program at Hashmicro. In this program, the author has the opportunity to become a Talent Acquisition Intern and is responsible for recruitment activities from the marketing department and business development department positions. This report will consist of three sections, including an introduction (containing the background of the participation and responsibilities of the author in the MBKM program), analysis and discussion (containing repetitive routine activities, non-routine activities, and skills and knowledge utilized and acquired during the program MBKM is in progress), and closing (contains conclusions, limitations, and the author's recommendations for this MBKM program)
PENYULUHAN PENINGKATAN LITERASI, NUMERASI DAN ADAPTASI TEKNOLOGI DI DAERAH TERDEPAN, TERPENCIL DAN TERTINGGAL
Authors: Bin Tambak Sutono , Musrifah Ai , Sari Dhyla Permata , Fatimah Widia , Kamilah Jidan , Permata Bunga Padilla , Damayanti Syfa Kaila
Published: August 2023

ABSTRAK Kegiatan pengabdian pada masyarakat merupakan salah satu bentuk implemntasi dari tri darma perguruan tinggi. Sekolah daerah 3T (Terdepan, Terpencil dan Tertinggal) perlu diperhatikan didalam proses pembelajarannya dan menjadi tanggung jawab kita semua, sehingga pemerintah memberikan sarana kepada perguruan tinggi untuk ikut serta memberikan perhatian kepada sekolah yang berada di 3T (Terdepan, Terpencil dan Tertinggal). Kegiatan Kampus mengajar Angkatan ke 3 yang merupkan program dari Kementrian Pendidikan, Kebudayaan, Riset Dan Teknologi, dengan mengankat tema Penyuluhan Peningkatan Literasi, Numerasi dan Adaptasi Teknologi di Daerah 3T (Terdepan, Terpencil dan Tertinggal) di SMPN Satu Atap 1 Langkaplancar Kabupaten Pangandaran. Kegiatan yang dilakukan pada pengabdian ini adalah berikan pembekalan kepada para siswa dalam adaptasi pembelajaran tatap muka pasca covid-19 dengan penguatan literas dan numerasi serta adaptasi teknologi, kegiatan pegabdian ini bekerjasama dengan mahasiswa dari berbagai perguruan tinggi yang masuk pada program KM3. Metode pelaksanaan pengabdian pada masyarakat ini dilakukan dengan team-based project yaitu dengan membuat perencanaan proyek dan produk sebagai luaran program, sehingga bisa memberi manfaat pada siswa dalam peningkatan pola belajar, jiwa kemempinanm soft skill, dan karakter dalam berinovasi. Dan dari kegiantan ini dapat dilihat pengingakatan kualitas literasi , numerasi dan adaptasi teknolgi dengan rata-rata meningkat 90%.ABSTRACTCommunity service activities are a form of implementation of the tri dharma of higher education. 3T regional schools (Leading, Remote and Disadvantaged) need to be considered in the learning process and are the responsibility of all of us, so that the government provides facilities for universities to participate and pay attention to schools that are in 3T (Terdepan, Terpencil, Tertinggal). Campus activities teach Batch 3 which is a program from Kemenristekdikti, with the theme of Counseling on Increasing Literacy, Numeracy and Technology Adaptation in 3T Regions (Terdepan, Terpencil, Tertinggal) at SMPN ONE ATAP 1 Langkaplancar, Pangandaran Regency. The activity carried out in this service is to provide provision to students in the adaptation of face-to-face learning after Covid-19 by strengthening literacy and numeracy as well as technology adaptation. This service activity works in collaboration with students from various tertiary institutions who are enrolled in the KM3 program. The method of implementing community service is carried out using a team-based project, namely by planning projects and products as program outputs, so that they can benefit students in improving learning patterns, leadership skills, soft skills, and character in innovation. And from this activity you can see an increase in the quality of literacy, numeracy and technology adaptation with an average increase of 90%.
СТАН ФУНКЦІОНАЛЬНОЇ АКТИВНОСТІ СЛИННИХ ЗАЛОЗ І ЧИННИКІВ НЕСПЕЦИФІЧНОГО ЗАХИСТУ ПОРОЖНИНИ РОТА У ДІТЕЙ 12–13 РОКІВ, ЩО СТРАЖДАЮТЬ ХРОНІЧНИМ КАТАРАЛЬНИМ ГІНГІВІТОМ
Authors: Терешина Т.П. , Заградська Е.Л. , Рябченко Е.Г. , Кірічек О.В. , Максименко В.В.
Published: August 2023

Мета дослідження. Вивчення стану ясен, швидкості салівації і чинників неспецифічного захисту порожнини рота у дітей пубертатного віку, що страждають хронічним катаральним гінгівітом, і виявленні взаємозв'язку між цими показниками. Матеріали і методи дослідження. Всього було обстежено 48 дітей 12–13-річного віку, з них 20 – з інтактним пародонтом і 28 дітей, що страждають хронічним катаральним гінгівітом. У дітей вивчали стан ясен (РМА), швидкість салівації і показники неспецифічного захисту – лейкоцитарний і епітеліальний. Результати дослідження. Дослідження проводили в порівняльному аспекті: діти з інтактним пародонтом і діти із запаленням ясен. Встановлено, що поширеність і інтенсивність запального процесу в групі «інтактні» була незначна і захоплювала лише окремі локальні ділянки ясенного сосочка. У дітей 2-ої групи поширеність запалення була висока (44%) – майже у половини зубного ряду виявлено запалення. Що стосується інтенсивності запалення, то рівень запалення наближався до максимально можливого показника – 3. Рівень салівації у спокої і при роздратуванні у дітей як з інтактним пародонтом, так і з гінгівітом, був значно нижчий нормальних значень, але при цьому у дітей з гінгівітом гіпосалівація виражена була більше. У хлопчиків рівень салівації був дещо вищий, ніж у дівчаток. Був зроблений висновок, що зниженню функціональної активності слинних залоз сприяє гормональний дисбаланс, що спостерігається у дітей пубертатного віку. При цьому механізм порушення салівації у дітей пубертатного віку обумовлений, в першу чергу, порушенням утворення слини. На користь цього припущення свідчить той факт, що у дівчаток, у яких статеве дозрівання настає дещо раніше, показники салівації нижчі. Далі вивчали важливі показники неспецифічної реактивності порожнини рота – міграцію лейкоцитів і злущування епітелію в ротовій порожнині. Дослідження показали, що у дітей з гінгівітом при порівнянні з показниками дітей з інтактним пародонтом виявлений більш високий вміст лейкоцитів і епітеліальних клітин в ротових змивах. При розгляді показників кожної дитини з групи з інтактним пародонтом максимальний зміст лейкоцитів в ротових змивах був в межах 458 тис. в 1 мл, у дітей же з гінгівітом злущування 856 тис. в 1 мл, тобто майже в 2 рази більше.
ШЛЯХИ КОМПЛЕКСНОГО ЛІКУВАННЯ НАБУТИХ ЗУБОЩЕЛЕПНИХ ДЕФОРМАЦІЙ НА ФОНІ ШКІДЛИВИХ ЗВИЧОК
Authors: Махлинець Н.П. , Ожоган З.Р. , Пантус А.В. , Яцинович В.І.
Published: August 2023

Мета дослідження. Підвищення якості комплексного лікування у дітей з набутими зубощелепними аномаліями на фоні шкідливих звичок. Методи дослідження. Проведені клінічні, рентгенологічні методи обстеження 60 пацієнтів із набутими зубощелепними аномаліями, деформаціями віком 12–15 років, та 15 осіб групи порівняння. Вивчали дані комп’ютерних томограм, проводили стереотопометричний аналіз (тривимірна цефалометрія), визначення товщини жувальних м’язів в симетричних ділянках лиця. Хворим проводили таємне анкетування з метою виявлення стресових чинників, які впливають на організм, вивчали залежність між наявністю стресового фактора та появою змін цефалометричних показників. Лікування проводили залежно від виду прикусу та шкідливої звички. Усі пацієнти у фазі активного ортодонтичного лікування мали змімні міофункціональні апарати (Myobrace, Froggymouth), піднебінні апарати (Hyrex, MARPE) у комбінації з незнімними апаратами (брекет- системи, Tiger force devices and Carrire Motion 3D). Статистичну обробку результатів проводили за допомогою персонального комп’ютера з використанням пакету програм Statistica 12.0. Розподіл даних оцінювали за допомогою критерію достовірності Колмогорова-Смирнова. Середні значення та стандартні помилки були розраховані для неперервних змінних. Кореляцію між параметрами аналізували за допомогою коефіцієнта кореляції Спірмена та перевіряли на достовірність. Значення було встановлено на p<0,05. Наукова новизна: Клінічне обстеження показало, що у 96,6% пацієнтів наявні шкідливі звички. Результати клініко-рентгенологічного обстеження, аналіз цефалометричних показників і даних про товщину жувальних м’язів на симетричних ділянках обличчя підтверджують зв’язок між хронічними шкідливими звичками та формуванням набутих аномалій щелепно-лицевої ділянки; підтверджують наявність набутої, а не вродженої деформації лицевого скелета, яка пов’язана зі зміною товщини жувальних м’язів з боку деформації та компенсаторною гіпертрофією м’язів з протилежного боку. Через 12 місяців цефалометричні показники пацієнтів достовірно відрізнялися від показників до активного ортодонтичного лікування та усунення шкідливої звички. Спостерігалося збільшення товщини м’язів у ділянках хронічної травми (р≤0,05). Спостерігалося збільшення товщини кісткової структури лицевого черепа і збільшення товщини жувальних м'язів з боку усунення шкідливої звички. Висновки. Шкідливі звички прогресують незалежно від віку пацієнта, діагностовано у 96,6% пацієнтів цієї групи пацієнтів. Результати клініко-рентгенологічного дослідження, аналіз цефалометричних показників і рівня товщини жувальних м'язів підтверджують зв'язок між хронічною оральною звичкою і розвитком кістково-м'язової системи. Отримані результати свідчать про здатність кісткової тканини змінювати свою товщину та контури після усунення шкідливої звички у досліджувальному віковому періоді пацієнтів та підтверджують наявність функціональної матриці розвитку кісткової структури.
Current situation of the guava agrifood chain in Zacatecas, Mexico
Authors: SÁNCHEZ-TOLEDANO Blanca , BORJA-BRAVO Mercedes , ZEGBE Jorge A. , FIGUEROA-GONZÁLEZ Juan José
Published: August 2023

Guava is one of the most important fruit crops in Zacatecas, Mexico. However, its permanence as an agrifood chain could be at risk. This research evaluated the current positioning of the guava chain. The information supporting these results was collected using the International Service for National Agricultural Research (ISNAR) methodology. The results indicated that guava is in a retraction status due to low socioeconomic importance and competitiveness. This situation is due to a significant decrease in the established area with guava, induced by various climatic, productive, and economic factors that growers have been experiencing. Therefore, it is necessary to improve crop productivity through the dissemination and adoption of technological innovations to improve yield.