bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Penerapan Metode Make A Match Berbantuan Media Kartu Domino Terhadap Minat dan Hasil Belajar Siswa Madrasah Ibtidaiyah Kota Palembang
Authors: Faisal Faisal , Samiha Yulia Tri , Nurlaeli Nurlaeli , Syarifuddin Ahmad
Published: September 2023

Penelitian ini merupakan tindak lanjut dari pengembangan bahan ajar yang telah dikembangkan lebih lanjut di MI Quraniah 8 Palembang pada tema 2 kenampakan tumbuhan dan hewan subtema 3 kenampakan tumbuhan pada pelajaran 1 yang valid. Jenis penelitian yang digunakan adalah kuantitatif untuk melihat tindak lanjut dari bahan ajar yang telah dikemukakan terhadap minat dan hasil belajar siswa kelas III. Minat belajar siswa kelas eksperimen mengalami peningkatan, mulai dari skor ratarata 88,25, skor maksimal 93, hingga skor minimal 83, sedangkan kelas kontrol menunjukkan skor rata-rata 80,00, skor minimal 72, dan skor maksimal 90. Sehingga dapat dituliskan bahwa ada peningkatan yang signifikan minat belajar siswa yang menggunakan metode make a match berbantuan media kartu domino dan siswa yang tidak menggunakan kartu domino. Hasil belajar siswa sesuai dengan hasil pengujian hipotesis pada taraf signifikan 5% (α = 0,05). Dengan pengujian terima H_0 jika t_(hitung ≤ ) t_tabel dan tolak H_0 jika t_hitung≥t_tabel dengan derajat bebas (dk)=(n_1+n_2- 2). Hasil uji hipotesis adalah 3,422 > 2,024 thitung > ttabel, artinya dapat diartikan bahwa ada pengaruh penerapan metode make a match berbantuan media kartu domino pada mata pelajaran tematik kelas IIIA MI Qur’aniyah 8 terhadap minat dan hasil belajar siswa.
Karakteristik Pelaksanaan Pembinaan Santri di Asrama Pondok Pesantren
Authors: Saputra Adam
Published: September 2023

The purpose of the implementation of fostering students in the hostel reveals the characteristics of the coaches of students through a process of approach, education, and habituation that is applied in a series of activities both inside and outside the hostel. This research is field research with a qualitative descriptive approach with natural characteristics as a direct data source. Data collection through observation techniques, interviews, and documentation. Data analysis techniques with inductive and deductive methods. The issues discussed include various characteristics of the implementation of coaching students in dormitories with various actuating, directing, leading, coordinating, and motivating elements. The results of this study indicate that Actuating characteristics have been applied properly and consistently with a good approach to fostering students in the dormitory. Characteristics of Directing by giving directions and providing various information related to what hostel activities will be carried out every day. Leading characteristics provide an example of a leader and the best role model for students in carrying out a series of activities for students in the dormitory. Coordinating Characteristics There is a good cooperative relationship or teamwork between Santri coaches, dormitory administrators, and OSPI administrators intensely in coordinating coaching in the dormitory to achieve goals effectively and efficiently. Motivating characteristics provide various motivations, and enthusiasm for learning and provide reasons why it must be implemented. This implementation has different characteristics such as the existence of an iqob system (educational punishment), role models, and a system of learning contracts, activity contracts, and contracts in the hostel. These efforts can provide solutions to foster properly according to the goals to be achieved.
Clinical observations of surgical treatment of patients with Pair syndrome
Authors: Makarov I. V. , Zaitsev V. E. , Korolev D. A. , Tyumin I. A. , Petrov A. B. , Panarin E. A. , Kudashova A. A.
Published: September 2023

The article provides a brief overview of the frequency and prevalence of Pair syndrome, the causes of its development, the clinical picture and diagnosis of this form of splanchnoptosis, the tactics of surgical treatment depending on the stage of the disease. There are 2 clinical cases of successful surgical treatment of chronic constipation in patients with Pair syndrome. At the same time, in the classical picture of the disease, left-sided hemicolectomy with a thick-colonic anastomosis "end to end" was performed, in a patient with concomitant diverticular disease - an extended hemicolectomy. All patients are discharged with recovery, all have an independent regular stool every 1-3 days
Dimeglumin chlorin E6 as a photo-sensitizer in photodynamic therapy in non-oncological diseases
Authors: Semenov D. Yu. , Shubin V. K. , Stranadko E. F. , Komarov R. N. , Ryabov M. V. , Bogomazov Yu. K. , Morokhotov V. A. , Shcherbyuk A. N. , Morozov S. V. , Zakharov Yu. I. , Bondarenko E. V. , Karpov N. V. , Flegontov P. B.
Published: September 2023

This review demonstrates the possibilities of photodynamic therapy in treatment of non-tumor pathologies using dimeglumine chlorin E6 as a photosensitizer. Initially, the method was invented for the treatment of cancer and demonstrated its effectiveness and safety. In present photodynamic therapy successfully used in the treatment of the bronchus, skin, stomach, cervix, larynx cancer. In addition to the treatment of different localization tumors, various studies demonstrated other positive effects of photodynamic therapy: antimicrobial, antimycotic, autoimmune, reparative. In the presented review, dimeglumine chlorin E6, which is a derivative of chlorin e6, acts as a photosensitizer. It demonstrates safety, high selectivity of accumulation in tissues, and is characterized by a short period of excretion from the body. Using of dimeglumine chlorin E6 cans significantly reduce the number of side effects associated with long-term skin phototoxicity.
Features of hemodynamic parameters during chronic and acute episodic introduction of ethanol to animals in model experiments
Authors: Pavlenko S. I. , Gromova D. S. , Vedyasova O. A. , Budaev A. I. , Inyushkin A. A.
Published: September 2023

Diseases of the cardiovascular system continue to occupy the first place in the world among all causes of death in the population. One of the leading medical and social factors in the growth of the number of cardiovascular pathologies is alcohol consumption.

The purpose of this work: to study the effect of chronic and acute episodic administration of ethanol on the features of hemodynamic parameters in rats.

Materials and methods. The study was carried out on non-linear mature male rats. The group that underwent acute administration of ethanol every five days (days 1,6, 11, 16, 21) was intraperitoneally injected with a 20 % ethanol solution (5 g/kg).The group subjected to chronic alcoholization was offered 10 % ethanol solution as the only source of liquid for 21 days. Every five days in both groups, hemodynamic parameters such as systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR) were recorded.

Results. With acute use of ethanol, already 30 minutes after administration, changes in hemodynamic parameters were found in the form of a decrease in SBP and DBP by an average of 43 %.60 minutes after the administration of ethanol, there was an increase in SBP and DBP by an average of 11 % relative to the initial data, which at the initial stage of alcohol consumption may be associated with a compensatory reaction of the cardiosystem in response to alcohol poisoning. Under conditions of chronic ethanol use, there was a decrease in the level of SBP, DBP and heart rate by an average of 16 % on the first day of the study, followed by their recovery to the initial values on the 21 st day of the study, which may be a sign of the development of a compensatory reaction of the body and indicate the beginning of the formation of alcoholic dependencies.

Conclusions. Acute and chronic administration of ethanol has a significant, but at the same time multidirectional effect on hemodynamic parameters, which can serve as a trigger for the development of various cardiopathologies.
Evaluation of the lightweight foamed concrete characteristics
Authors: Etman Zeinab A. , Rokbah Samar A.
Published: September 2023

The purpose of this paper is to assess the properties of light weight foamed concrete. In this research, two phases are investigated. The first stage explored the characteristics of fresh and hardened foamed concrete using a foaming agent. The following parameters were employed in this study: foaming agent used as a volume of concrete mix by 10, 20, and 40%, fly ash used as a replacement of cement content by 10, 25, and 50%, and polypropylene fiber used with varied volume fractions of 0.5, 0.75, and 1.0%. Slump values are applied to evaluate the fresh properties. To evaluate the hardened concrete, the dry density and compressive strength at 7 and 28 days are computed. Furthermore, the 28-day tensile splitting strength and flexural strength are studied. The effect of a high temperature was evaluated. The second stage investigated the effects of polypropylene fiber on both fresh and hardened concrete. It was observed that foaming agents improve fresh characteristics while decreasing compressive strengths and dry density. Furthermore, utilizing fly ash improves the characteristics of both fresh and hardened foamed concrete. The fiber reduces the fresh characteristics while enhancing the toughened properties. Because of its low density, foamed concrete is being used for structural applications because of this study. Such as those utilized for thermal insulation, acoustic impedance, and fire breaks. Also used to create road foundations for roads built on soft soil.
Three-dimensional static analysis of reinforced concrete cantilever beam using MATLAB Partial Differential Equation Toolbox
Authors: Köksal Olgun , Karaca Zeki , Türkeli Erdem
Published: September 2023

Nowadays, three-dimensional (3D) solid model of the structures can be prepared by using computer aided design programs. There are many numerical methods for static, dynamic and temperature analysis of structural systems. The most preferred among these methods is the finite element method (FEM). In this method, the structural model with different geometry and boundary conditions should be solved by utilizing partial differential equations. Due to the long solution time while performing, finite element programs require computers with very good features. Therefore, analyses with desired features can be performed by using open source programs to shorten the duration of analysis. In this study, specifically, the static analysis of the selected reinforced concrete (RC) cantilever beam was carried out by using the open source MATLAB partial differential toolbox based on the FEM. Since the program used is open source, different concrete classes and finite element models were selected for the cited cantilever beam and static analyses were performed. As a result of the MATLAB partial differential toolbox analyses, the displacement, stress and deformation of the cantilever beam were obtained in 3D and compared with the ones obtained from ANSYS computer program.
Phylogenomic Inference, Divergence-Time Calibration, and Methods for Characterizing Reticulate Evolution
Authors: Bjornson Saelin , Upham Nathan , Verbruggen Heroen , Steenwyk Jacob
Published: September 2023

Phylogenomics has enriched our understanding of the Tree of Life. Non-vertical modes of evolution—such as hybridization/introgression and horizontal gene transfer—deviate from a strictly bifurcating tree model, mirroring a network-like or reticulate structure. Here, we present an overview of a phylogenomic workflow for inferring organismal histories, calibrating those histories to evolutionary time, and detecting reticulate evolution. Mitigating analytical sources of error facilitates accurate reconstructions of evolutionary history and, in turn, characterization of non-vertical modes of evolution. Workflows and methods discussed herein may aid in the rigorous inference of organismal histories in geologic time and reticulation, providing a clearer understanding of the evolutionary process.
The Comparison of Numerical Simulations of Offshore and Onshore Wind Turbines with Experimental Data. Part I: Unsteady State Flows
Authors: AsemanBakhsh Mohammad Ali , Karimi Omid
Published: September 2023

It is imperative to examine the performance of wind turbines both in steady and unsteady states due to their significant role in generating renewable energy by utilizing wind power. The computational fluid dynamics method (CFD) is one of the most efficient tools in this field, and the unsteady state has a great deal of importance when predicting turbine performance. Using the CFD method, the hydrodynamic performance of two types of offshore and onshore horizontal-axis wind turbines in the unsteady state was examined. Offshore wind turbines were modeled using the SST turbulence model and onshore wind turbines were modeled using the large eddy simulation (LES). Three-dimensional results of the simulation were compared and validated with experimental results, and good agreement between the two results indicates that the assumptions and method were accurate. Vortices were also studied in relation to the blade tip and their formation and development. Increasing the number of blades results in a reduction in torque, as well as a rise in vortices caused by the tips of the rotor blades. Due to the intensity of turbulence, the distribution of pressure on the surfaces will become irregular as the wind speed increases.
T Lymphoblastic Lymphoma Hiding in Mature Plasmacytoid Dendritic Cell Proliferation: A Case Report and Literature Review
Authors: Deng Cong , Gao Bei-bei , Wang Tian-li , Chang Xiao-Na , Xiao Gui-xiang , Xia Qin , Pan Hua-xiong , Nie Xiu
Published: September 2023

To the best of the author’s knowledge, studies of mature plasmacytoid dendritic cell proliferation associated with T lymphoblastic lymphoma were extremely rare in the literature. Here, we report a patient who underwent both mature plasmacytoid dendritic cell proliferation and T lymphoblastic lymphoma. With the findings of lymph node biopsy taken from the right cervical and inguinal regions, we identified eye-catching mature plasmacytoid dendritic cells that were considered to be responsible for this lesion at the beginning, until the immunostaining of Ki67 and TDT showed a small group of positive cells hiding in these plasmacytoid dendritic cells. Bone marrow biopsy was also performed in this patient. Microscopically, the hematopoietic tissue was almost completely replaced by lymphoblastoid cells with condensed chromatin, inconspicuous nucleoli and scanty cytoplasm, which were basically the same as those seen in the lymph nodes in morphology. However, there was no sign of plasmacytoid dendritic cells or Langerhans cells in the bone marrow biopsy. With the help of bone marrow biopsy, our final diagnosis of the lymph node was T lymphoblastic lymphoma coexisting with mature plasmacytoid dendritic cell proliferation . Although accumulations of plasmacytoid dendritic cells may occur in some infections or reactive lymphadenopathy, the presence of extensive nodules or infiltration of plasmacytoid dendritic cells strongly reminds the pathologist to carefully evaluate the bone marrow or peripheral blood status of the patient to exclude a hidden myeloid or other neoplasm.
PENGARUH PENGGUNAAN BOX POWER IGNITION TERHADAP KONSUMSI BAHAN BAKAR SEPEDA MOTOR KARBURATOR
Authors: Wibowo Hengky Prasetyo
Published: September 2023

Jurnal ini membahas tentang penggunaan Box Power Ignition yang berpengaruh dengan konsumsi bahan bakar pada sepeda motor karburator
Statistical accounting improvement as a measure to increase the effectiveness of prevention of circulatory system diseases.
Authors:   The first St. Petersburg state medical University named after I. P. Pavlov of the Ministry of health of the Russian Federation, Vishniakov N.I. , Kochorova L.V. ,   The first St. Petersburg state medical University named after I. P. Pavlov of the Ministry of health of the Russian Federation, Apresyan A.Yu. ,   Northwestern State Medical University named after I. I. Mechnikov of the Ministry of Health of the Russian Federation
Published: September 2023

Improving the provision of medical care for diseases of the circulatory system, including disease prevention, is an urgent problem, the solution of which is carried out in the Russian Federation at the state level. Purpose of the study is to evaluate information on the features of accounting for peripheral artery diseases and the level of their prevalence on the basis of information contained in official statistical reporting forms. Materials and methods. Based on the information of medical organizations contained in official statistical reporting forms No. 12 and No. 14, an assessment of the features of accounting for peripheral artery diseases and their prevalence in St. Petersburg for the period from 2015 to 2020 was carried out. In order to neutralize the influence of regional peculiarities of the organization of medical care during the pandemic of a new coronavirus infection, 2019 was chosen as the main research period. Extensive and intensive indicators were calculated with an assessment of the reliability of their difference, a correlation analysis was carried out. Results. The official statistical forms take into account a limited list of diseases of the peripheral arteries, which accounts for only 1,2% in the structure of diseases of the circulatory system in St. Petersburg. The proportion of other diseases of the circulatory system that are background is high: high blood pressure – 38,7%, cerebrovascular diseases – 25,5%, coronary heart disease – 22,5%. At the same time, the contribution of peripheral artery diseases in assessing their long–term consequences is significant – there is an increase in the level of surgical interventions, including amputations. In addition, a strong correlation was established between the prevalence of peripheral artery diseases and background diseases (p = 0,78; p < 0,01), which indicates a “cumulative effect” of peripheral artery diseases in the population. Conclusions. It is necessary to develop separate preventive programs for patients with peripheral artery diseases, the instrument of which can be the organization of their effective accounting by means of a register specially created for these purposes.
Experience in the application of artificial intelligence technologies for the development of preventive health care on the example of the Kirov region.
Authors:   Government of the Kirov Region, Kurdyumov D. A. , Kashin A. V. ,   KOGBUZ “MIAC, TsOZMP”, Ryabov N.Yu. ,   KOGBUZ “MIAC, TsOZMP”, Novitsky R. E. ,   K-Sky, Petrozavodsk, Gusev A. V. ,   Russian Research Institute of Health
Published: September 2023

Healthcare is one of the priority sectors for the practical application of artificial intelligence (AI) systems. In 2018, in the Kirov region, it was decided to launch its own regional project for the implementation of AI technologies in order to gain practical experience and understand the features, advantages and barriers to the use of AI. Improvement of preventive medicine was chosen as a priority direction. The Russian predictive analytics platform Webiomed was chosen as the base software product. The project implementation included 3 stages: pilot testing in 2019–2020, commercial operation in the “second opinion” mode in 2021–2022. and implementation in the digital assistant mode, launched in 2023. As a result of the implementation of the 1st and 2nd stages of the project, it was possible to prove that the main advantage of AI in the analysis of big medical data is the autonomous and high accuracy of interpretation of the information available in it. An AI system for independently extracting the data necessary for analysis from electronic medical records, comparing them with data from past periods, assessing the dynamics of changes in health indicators, and identifying the emergence of dangerous trends and risk factors. Together, this allows the formation of the so-called “digital profiles” of patients, which in turn are a valuable resource for supporting management and clinical decision-making.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 09.09.2023 г. по 15.09.2023 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: September 2023

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 09.09.2023 г. по 15.09.2023 г.
Monetization of emotions in the existence of an electronic nomad
Authors: Iakovleva E. L.
Published: September 2023

Objective: to perform a philosophical analysis of the problem of emotions monetization, which is currently expanding the scope of manifestations and effects, as well as to disclosure the causes and features of this process.

Methods: existential-phenomenological, analytical and logical, as well as structural and system-functional approaches. The ideas of D. Harvey, J. Baudrillard, N. Srnicek, R. van den Akker, A. Gibbons and T. Vermeulen on the state of modern society served as material for theoretical comprehension of the problem.

Results: the research revealed that today the emotions monetization plays a significant role both in the life of a modern individual spending a lot of time in social networks, whom we call an electronic nomad, and of producers of goods and services, advertisers and intermediaries, bringing large profits to the latter. The consumerism ideology and the consumer society contribute to the emotions monetization, as well as the two-world, chaotic and fragmented here-existence of an electronic nomad, their loneliness and unstable structure of feelings. Consumption is not rationalized by a modern individual; it is associated with the desire for excess and is subject to a change of emotions and feelings. The nomad relies on advertising to satisfy his needs, where they are offered a product/service in an excellent form as a tempting deficiency. Today, to construct an advertising myth, databases and various platforms are used, targeting of potential customers is carried out, which allows manipulating their emotions and forcing them to make a choice. At the same time, the purchase of a product or service is associated with quickly forgetting the emotions, and possibly with subsequent disappointment. The electronic nomad, yielding to emotions, demonstrates lack of will, manipulability, and lack of reflexivity over what is happening.

Scientific novelty: the results of the analysis of the current state of consumer society allow posing the problem of emotions monetization, identifying the reasons for the intensive development of this process in an electronic nomad, and discovering the features of manipulation tactics that lead to the conversion of emotions into monetary equivalent.

Practical significance: consists in using the research results for further study of monetization using databases, recognizing the manipulative tactics exploiting the emotions of an electronic nomad, and problematizing the totality of emotions monetization and improving the quality of goods/services common in modern society.
Criminal risks of medical robots turnover
Authors: Shutova A. A.
Published: September 2023

Objective: to identify criminal risks inherent in a medical robot, taking into account its hardware-technological (technological and digital) features, and to construct, based on this analysis, the author’s classification of criminal risks and models of criminal-legal protection of public relations arising in the medical robots’ turnover.

Methods: the article uses general scientific (analysis, synthesis, induction, deduction, classification) and specific scientific methods of cognition, and the logical-legal method.

Results: The security vulnerability of medical robots causes serious concern in manufacturers, programmers and those interacting with the robots in the healthcare industry. In medical institutions, robots interact closely with children, the elderly and the disabled, and it may not be clear to the patient whether the robot is working properly or being attacked. Any harm caused by a surgical robot as a result of unauthorized access (or other illegal actions) can undermine the public’s faith in medicine and in the healthcare system as a whole. Threats to the safety of medical robots can have further negative consequences for themselves, as such facts of unlawful influence can lead to robots breaking down or harming other nearby equipment that is the property of the healthcare institution, and worse – the life and health of patients or medical workers. In this regard, the paper identifies criminal risks and threats inherent in medical robots, and formulates measures to improve criminal legislation aimed at countering crimes arising against the legal turnover of medical robots (Article 2352 of the Criminal Code of the Russian Federation).

Scientific novelty: at the moment there are few Russian studies devoted to the legal regulation and protection of medical robots. Basically, such researches are done by medical scientists. However, in the Russian Federation, there are practically no special theoretical-legal studies, including those devoted to the study of criminal law issues of the protection of these legal relations, which confirms the relevance and significance of our research.

Practical significance: the provisions and conclusions of the article can be used to further improve criminal legislation, and also lay the foundation for further research in criminal law science.
Destructive social movements “Maniacs. Killing cult” and the “World of maniacs and serial killers”: forming a criminal ideology
Authors: Glukhova A. A. , Iudin A. A. , Shpilev D. A.
Published: September 2023

Objective: analysis of the semantic field of Internet publics of destructive social groups “Maniacs. The cult of murder” and “The world of maniacs and serial killers”, the reasons for the interest of teenagers and young people in these groups, the techniques used by moderators of social network pages to attract supporters and form a cult of violence among them and stimulate the commission of murders based on the research results (multidimensional content analysis of the social network pages content).

Methods: general scientific (analysis, system-structural, comparative-legal) and specific scientific methods (multidimensional content analysis of the social network pages content).

Results: based on the analysis of more than 17 thousand fragments of correspondence of participants of the movement “Maniacs. The cult of murder” and more than 34 thousand fragments of correspondence of participants of the movement “The world of maniacs and serial killers”, a semantic field was constructed, including the main topics discussed on the pages of the above-mentioned destructive social groups, methods of involving teenagers in a destructive total ideology modeling the most important spheres of life of the movements’ supporters, leveling the value of human life and turning someone else’s death into an ordinary phenomenon. It is concluded that within the framework of the destructive radical nationalist social movement “Maniacs. The cult of murder” an ideology was formed that has the following features: teleology, scientific appearance, wide audience coverage, presence of symbols and attributes, discussion of topics that have a socially negative character, using the language means that are understandable only to the community members.

Scientific novelty: the main topics discussed by participants of destructive social movements “Maniacs. The cult of murder” and “The world of maniacs and serial killers” are described and analyzed. It is proved that as a result of immersion into such content, violence and murder cease to cause natural negative emotions, feelings of disgust and empathy for the victim in teenagers. The study showed that the formation and distribution of content in publics currently takes place on behalf of the users, which, on the one hand, allows removing part of the responsibility from the moderators, and on the other hand, turns the pages of movements into a so-called self-reproducing (by terminology of Niklas Luhmann – autopoietic) system capable of self-production, i.e. its existence is ensured by the activity of the users.

Practical significance: the article materials can be useful to federal and regional authorities in implementing various aspects of youth policy, preventing sociopathic behavior of young people, ensuring the safety of educational institutions; to parents and family members of problem adolescents; and to scientists researching destructive youth network movements.
The video game industry’s money laundering problem: when do game publishers become money transmitters?
Authors: Roomberg M.
Published: September 2023

Objective: to study the problem of money laundering in video game industry and to develop measures to minimize this illegal behavior.

Methods: dialectical approach to cognition of social phenomena, allowing to analyze them in historical development and functioning in the context of the totality of objective and subjective factors, which predetermined the following research methods: formal-logical and sociological.

Results: as enthusiasm for immersive multiplayer video games continues to grow, players are placing a high degree of value on virtual items like in-game currency, weapons, vehicles, and “skins”. The value of these items, paired with features that allow players to buy and sell them, has opened the door to criminals who can exploit these features to launder money. The United States maintains a robust legal framework to prevent and punish money laundering. One key piece of that framework is imposing certain reporting and recordkeeping duties on “financial institutions”, including money transmitters. If a company is subject to these duties, it must abide by complex and expensive anti-money laundering compliance requirements.

Scientific novelty: the article, for the first time, considers the issue whether a game publisher is a criminal money transmitter. The paper takes up that question detailing the specific game features and publisher policies that, under current rules and guidance, lead to or rebuff the conclusion that a game publisher is a money transmitter.

Practical significance: the main provisions and conclusions of the article can be used in scientific, pedagogical and law enforcement activities when considering the issues related to the qualification of actions of video games publishers in case of their participation in money laundering.

The article was first published in English language by Fordham Law Review Online. For more information please contact the editorial office.

For original publication: Roomberg, M. (2023). The video game industry’s money laundering problem: when do game publishers become money transmitters?, Fordham Law Review Online, 91, 161–177.

Publication URL: https://fordhamlawreview.org/law-review-online/the-video-game-industrys-money-laundering-problem-when-dogame-publishers-become-money-transmitters/
Study on the antipyretic activity and potential mechanism of Indigo Naturalis on lipopolysaccharide-induced fever rat model
Authors: Xu xiaorong , Huang Shengjie , Luo Chuanhong , Xu Runchun , Wang Fang , He Yanan , Yang Ming , Lin Junzhi , Han Li , Zhang Dingkun
Published: September 2023

Background As a Traditional Chinese Medicine with an antipyretic effect, Indigo Naturalis (IN) has a long history of application in China. It is often used with other heat-clearing drugs to treat high fever in children, which is different from other heat-clearing medicines. But its antipyretic effect and mechanism have not been fully elucidated yet. And the heat-clearing development of IN lacks convincing current evidence.
Methods This study aimed to uncover the antipyretic effect and mechanism of IN on infectious fever by rectal temperature, pyrogen cytokines and metabolomics. Materials and Methods Firstly, the antipyretic effect of IN on LPS-induced fever rats was evaluated by the changes in rat rectal temperature. Then, the content of PGE2 and cAMP in the hypothalamus and TNF-α, IL-1β and IL-6 in the serum were determined by ELISA. Finally, the plasma and urine samples of febrile rats were analyzed in combination with UHPLC-Q-TOF-MS to explore the antipyretic mechanism of IN.
Results Compared with pyrexia model rats, the rectal temperature of rats treated with Indigo Naturalis was suppressed after 0.5 h (P <0.01). The enzyme-linked immunosorbent assay (ELISA) showed that the expression of tumor necrosis TNF-α (P <0.01) and IL-6 (P <0.05) were suppressed by IN. A total of 11 endogenous metabolites were identified from the plasma samples of the IN group, the model group and the control group. Furthermore,15 metabolites were identified in the urine samples. Pathway analysis showed that IN mainly regulated glycerophospholipid metabolism, glucuronide mutual conversion and tryptophan metabolism.
Conclusion This study clarified the exact effect of IN on infectious fever. It mainly works by regulating pyrogenic cytokines and glycerophospholipid pathways. The present research provided a deeper understanding of the traditional heat-clearing effect of IN. It provided a reference for the further scientific research of IN and the selection of antipyretic drugs in clinical practice.
Prediction of cancer treatment response from histopathology images through imputed transcriptomics
Authors: Ruppin Eytan , Hoang Danh-Tai , Dinstag Gal , Hermida Leandro , Ben-Zvi Doreen , Elis Efrat , Caley Katherine , Sammut Stephen-John , Sinha Sanju , Sinha Neelam , Dampier Christopher , Stossel Chani , Patil Tejas , Rajan Arun , Lassoued Wiem , Strauss Julius , Bailey Shania , Allen Clint , Redman Jason , Beker Tuvik , Jiang Peng , Golan Talia , Wilkinson Scott , Sowalsky Adam , Pine Sharon , Caldas Carlos , Gulley James , Aldape Kenneth , Aharonov Ranit , Stone Eric
Published: September 2023

Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin (H&E)-stained tumor slides for precision oncology. We present ENLIGHT-DeepPT, an approach for predicting response to multiple targeted and immunotherapies from H&E-slides. In difference from existing approaches that aim to predict treatment response directly from the slides, ENLIGHT-DeepPT is an indirect two-step approach consisting of (1) DeepPT, a new deep-learning framework that predicts genome-wide tumor mRNA expression from slides, and (2) ENLIGHT, which predicts response based on the DeepPT inferred expression values. DeepPT successfully predicts transcriptomics in all 16 TCGA cohorts tested and generalizes well to two independent datasets. Our key contribution is showing that ENLIGHT-DeepPT successfully predicts true responders in five independent patients’ cohorts involving four different treatments spanning six cancer types with an overall odds ratio of 2.44, increasing the baseline response rate by 43.47% among predicted responders, without the need for any treatment data for training. Furthermore, its prediction accuracy on these datasets is comparable to a supervised approach predicting the response directly from the images, which needs to be trained and tested on the same cohort. ENLIGHT-DeepPT future application could provide clinicians with rapid treatment recommendations to an array of different therapies and importantly, may contribute to advancing precision oncology in developing countries.
Effects of the inclusion of physical activity in secondary education academic classes on educational indicators and health markers: Rationale and methods of the ACTIVE CLASS study
Authors: González-Pérez María , Sánchez-Oliva David , Grao-Cruces Alberto , Cano-Cañada Enrique , Martín-Acosta Fátima , Muñoz-González Raúl , Bandera-Campos Francisco J. , Ruiz-Hermosa Abel , Vaquero-Solís Miguel , Padilla-Moledo Carmen , Conde-Caveda Julio , Segura-Jiménez Víctor , González-Ponce Inmaculada , García-Calvo Tomás , Castro-Piñero José , Camiletti-Moirón Daniel
Published: September 2023

Background: Physical inactivity and sedentary levels among children and adolescents are significant concerns. The school setting presents an ideal scenario for implementing strategies aimed at improving physical activity (PA) levels and reducing sedentary behaviours. However, most of the interventions have primarily focused on children, and limited evidence is available for adolescents. This paper presents the design, measurements, and interventions implemented in the ACTIVE CLASS study, which aim to assess the effects of two interventions on PA levels, sedentary time, health-related physical fitness academic indicators, cognition, and markers of psychological health among secondary education students.
Methods: A randomized controlled study is conducted with a total of 292 students from six schools (7th and 8th grade) in Spain (three in Cadiz and three in Caceres). One school from each study region is randomly assigned to either the active break intervention group, the physically active learning intervention group, or the control group. The interventions have a duration of 16 weeks. Nine main measurement categories are assessed: PA and sedentary time, health-related physical fitness, academic indicators, cognition, psychological health, motivational variables, dietary patterns, sociodemographic characteristics, and qualitative information. Three temporal moments of evaluation are distinguished: pre-intervention, post-intervention (week 16) and retention measurement (four weeks after the intervention). Qualitative information is assessed solely during the post-intervention measurement.
Discussion: To the best of our knowledge, the ACTIVE CLASS study is the first of its kind in Spain to evaluate the effects of incorporating active breaks and physically active learning in secondary education. Moreover, this project will offer valuable and innovative training to the educational community, enabling them to implement teaching methodologies that have the potential to enhance academic performance and improve the quality of life for their students.
Trial registration: NCT05891054 (clinicaltrials.gov), 06/06/2023.
Positive and negative effects of administering a magnetic field to patients with rheumatoid arthritis (RA)
Authors: Zwolińska Jolanta , Kasprzak Marta , Kielar Aleksandra , Prokop Michał
Published: September 2023

Magnetotherapy applied to patients with rheumatoid arthritis (RA) produces anti-inflammatory, analgesic and antioedema effects. Observations suggest that beneficial and adverse effects of magnetotherapy are related to the parameters of the magnetic field applied. The study aimed to assess the positive and negative effects of magnetotherapy, taking into account the type of the field. The study involved 39 patients with RA, who were randomly assigned to two groups: SMF - static magnetic field (n = 18) and PEMF – low-frequency pulsed electromagnetic field (n = 21). The examinations carried out before and after the therapy included a general assessment of the functional status, assessment of pain severity, measurement of the duration and severity of morning stiffness, computer-aided measurement of the range of motion of the hand joints and measurement of hand volume using water displacement method. The patients received kinesiotherapy and magnetotherapy, as determined by the randomisation. The findings show improved functional status (HAQ-20) on average by 0.26 points (p = 0.0166*), reduced pain (VAS) on average by 2.2 points (p = 0.0000***), reduced duration of morning stiffness on average by 23.2 min. (p = 0.0010**), and reduced severity of morning stiffness on average by 15.2 points (p = 0.0010**). The assessment of the dominant hand showed improved range of motion on average by 1.9 mm (p = 0.0036**) and reduced volume on average by 0.9 mm3 (p = 0.0230*). Significantly reduced duration and severity of morning stiffness was observed in SMF Group. Statistically significant changes in HAQ-20 scores, range of motion and the volume of the dominant hand were identified in PEMF Group. Magnetic fields improve functional status, and reduce pain, morning stiffness as well as swelling in the hand. A static magnetic field may be more effective in reducing morning stiffness whereas a pulsed magnetic field may, to a greater extent, improve function and reduce swelling in the rheumatoid hand. The side effects of magnetotherapy reported so far require further observation.
Trial registration: ClinicalTrials.gov (NCT05920746; URL: www.clinicaltrials.gov). Day of first registration 27/06/2023.
New insights from old data - Hunting for compounds with novel mechanisms using cellular high-throughput screening profiles with Grey Chemical Matter
Authors: Renner Steffen , Thomas Jason , Shelton Claude , murphy jason , Brittain Scott , Bray Mark-Anthony , Aspesi Peter , Concannon John , King Frederick , Ihry Robert , Ho Daniel , Henault Martin ,   Andrea Hadjikyriacou1, Neri Marilisa , sigoillot frederic , Pham Helen , Shum Matthew , Barys Louise , Jones Michael , Martin Eric , Blechschmidt Anke , Rieffel Sébastien , Troxler Thomas , Mapa Felipa , Jenkins Jeremy , Jain Rishi , Kutchukian Peter , Schirle Markus
Published: September 2023

Identifying high quality chemical starting points is a critical and challenging step in drug discovery, which typically involves screening large compound libraries or repurposing of compounds with known mechanisms of actions (MoAs). Here we introduce a novel cheminformatics approach that mines existing large-scale, phenotypic high throughput screening (HTS) data. Our method aims to identify bioactive compounds with distinct and specific MoAs, serving as a valuable complement to existing focused library collections. This approach identifies chemotypes with selectivity across multiple cell-based assays and characterized by persistent and broad structure activity relationships (SAR). We prospectively demonstrate the validity of the approach in broad cellular profiling assays (cell painting, DRUG-seq, Promotor Signature Profiling) and chemical proteomics experiments where the compounds behave similarly to known chemogenetic libraries, but with a bias towards novel protein targets and required no synthetic effort to improve compound properties. A public set of such compounds is provided based on the PubChem BioAssay dataset for use by the scientific community.
Medical students’ experiences of guided reflection on early clinical exposure: A qualitative study
Authors: Farajpour Arezou , Salehi Armin , Mashoufi Rasam
Published: September 2023

Introduction: Early clinical exposure in medical curricula can help students understand the social context of medicine and facilitate their transition to the clinical environment. To investigate the experiences of medical students in this regard, a study was designed and implemented with a focus on guided reflection.
Methods: In this qualitative study, 2nd-semester medical students underwent guided reflection and were asked to respond to open-ended questions in written form after their initial clinical exposure in teaching hospitals. The written answers provided by the students were analyzed using open coding to extract semantic units, subcategories, categories, and themes.
Findings: The responses of 52 participating students were coded, resulting in the extraction and formation of 279 semantic units, 22 codes, nine subcategories, five categories, and two themes.
Conclusion: Guided reflection through early clinical exposure lays the foundation for developing core competencies, including communication skills, problem-solving and clinical reasoning abilities, personal development, and the cultivation of professional identity and professionalism among medical students.
Development of high-performance zero-gap carbon dioxide electrolysis cells using a hydrophilic porous membrane
Authors: Kiyota Yasuhiro , Kofuji Yusuke , Kudo Yuki , Yonetsu Maki , Ono Akihiko , Mikoshiba Satoshi , Kitagawa Ryota
Published: September 2023

A hydrophilic porous membrane is adopted as the diaphragm in zero-gap CO2 electrolysis cells in order to improve their efficiency and durability. The hydrophilic porous membrane is sparse and nonpolar, which are features opposite to those seen in the anion-exchange membranes commonly used as the diaphragm in CO2 electrolysis cells. These characteristics result in high ion permeability, which contributes to decreased power consumption. A cell with an active area of 16 cm2 achieves high Faradaic efficiency of 90% at a current density of 1000 mA/cm2 and a lower cell voltage compared with anion-exchange membranes. Optimization of the operating temperature achieves maximal energy efficiency of around 50% at 200 mA/cm2 under neutral electrolyte conditions. Excellent chemical stability of the porous membrane is demonstrated through experiments in a simulated practical environment and under long-term operation with application of a variable power source and introduction of impurity gases. The cells using the membrane was operated for an unprecedented 1000 h in a 400 mA/cm2 durability test. Furthermore, a CO2 electrolysis cell scaled up to a 10 × 100 cm2 cell stack is demonstrated as a step toward the development of an industrial-scale CO2 electrolysis cell. These results suggest that the hydrophilic porous membrane is a promising diaphragm option for the practical application of CO2 electrolyzers.
Morphological and Physiological Responses of Suaeda salsa under Drought and Salt Stress
Authors: Li Jialei , Wang Yuwei , Bao Jinbo , Ding Zhijie , Yisilam Gulbar , Chu Zhenzhou , Su Ying , Wang Qiuyan , Tian Xinmin
Published: September 2023

Drought and salt stress are major constraints for agricultural survival and development. Suaeda salsa is one of the hot spots plants in the study of drought- and salt-tolerant with important soil improvement and ecological restoration roles. Therefore, it is significant to understand the effects of water shortage and salt stress on physiological and biochemical properties of plants. In the study, two different horizontal gradients were set up to measure the phenotype, physiological and biochemical characteristics of S. salsa under drought and salt stress. The results showed that drought and salt stress inhibited the growth of S. salsa. Different salt concentrations significantly increased the activities of catalase (CAT), superoxide dismutase (SOD) and peroxidase (POD). With increasing concentration of salt stress, malondialdehyde (MDA), soluble protein and soluble sugar contents showed an upward trend, while chlorophyll b and carotenoid contents first decreased, and then increased by 28.21% and 45.45% due to the accumulation of proline. As drought stress concentration increased, the POD activity first decreased and then increased, while soluble protein contents showed an opposite trend. Under severe drought, chlorophyll a/b and carotenoid contents decreased by 52.0%, 57.01%, and 20.00%, respectively. Our results indicated that drought and high salinity inhibited the growth, morphology, and most physiological and biochemical characteristics of S. salsa, while the activities of antioxidant enzymes, content of osmotic adjustment substances and photosynthetic pigments might be related to the accumulation of proline.