bluuebunny/crossref_metadata_2025 huggingface dataset:
Corrosion Inhibition Study on (Z)-N’-(1-phenylethylidene) benzohydrazide Derivatives on Carbon Steel in Acidic Solutions.
Authors:   Department of Basic Sciences, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria, Abel Kolawole Oyebamiji , David Kehinde Adeleke ,   Department of Basic Sciences, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria, Ismail Olawale Akande ,   Department of Basic Sciences, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria, Ayomide Peter Ajayi ,   Department of Basic Sciences, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria, Ibraheem Ayobami Oladosu ,   Department of Basic Sciences, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria, Festus Akintunde Ojeniyi ,   Department of Pure and Applied Physics, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, Nigeria., Esther Opeyemi Oyebamiji ,   Department of Pure and Applied Physics, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, Nigeria., Sunday Adewale Akintelu ,   School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, China., Banjo Semire ,   Computational Chemistry Research Laboratory, Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Oyo State, Nigeria.
Published: March 2022

Decomposition of carbon steel via corrosion process has caused a serious damage to several organisations worldwide. Despite efforts put in place to curb this menace by scientists, havoc caused by corrosion of metal still remain. Therefore, in a way to find effective corrosion inhibitor, (Z)-N'-(1-phenylethylidene) benzohydrazide derivatives was optimised using density functional theory and the obtained molecular descriptors correlated well with the experimental percentage inhibition efficiency. Also, the developed quantitative structure-activity relationship study (QSAR) model revealed that dipole moment impeccably define anti-corrosion properties of (Z)-N'-(1-phenylethylidene) benzohydrazide Derivatives.
Novel air sterilization process for clean air production and microbial spread limitation using protection devices.
Authors:   Centre d’Analyses et de Recherche (CAR), Unité de Recherche Technologies et Valorisation agro-Alimentaire (UR-TVA), Faculté des Sciences, Université Saint-Joseph de Beyrouth, Campus des sciences et technologies, Mar Roukos, Matn, Liban, Assaf Jean Claude ,   Chemical Engineering Laboratory, Department of Chemical and Petrochemical Engineering, Faculty of Engineering, Lebanese University, Lebanon,   Chemical Engineering Laboratory, Department of Chemical and Petrochemical Engineering, Faculty of Engineering (ESIB), Saint Joseph University, Mar Roukos, Matn, Lebanon,   Research Laboratory of Microbiology, Department of Life and Earth Sciences, Faculty of Sciences I, Lebanese University, Hadat Campus, Beirut, Lebanon,   Department of Chemical Engineering, Faculty of Engineering, University of Balamand, Koura, Lebanon, Geitani Régina ,   Laboratoire des agents pathogènes, Faculté de pharmacie, Université Saint-Joseph de Beyrouth, Campus des sciences médicales, Riad El Solh, Liban, Karam Sarkis Dolla ,   Laboratoire des agents pathogènes, Faculté de pharmacie, Université Saint-Joseph de Beyrouth, Campus des sciences médicales, Riad El Solh, Liban, Maroun Richard ,   Centre d’Analyses et de Recherche (CAR), Unité de Recherche Technologies et Valorisation agro-Alimentaire (UR-TVA), Faculté des Sciences, Université Saint-Joseph de Beyrouth, Campus des sciences et technologies, Mar Roukos, Matn, Liban, Louka Nicolas ,   Centre d’Analyses et de Recherche (CAR), Unité de Recherche Technologies et Valorisation agro-Alimentaire (UR-TVA), Faculté des Sciences, Université Saint-Joseph de Beyrouth, Campus des sciences et technologies, Mar Roukos, Matn, Liban
Published: March 2022

This work aims to develop and simulate a novel process based on sterilizing natural air by heating at high temperatures followed by rapid cooling. The new sustainable process is called “Air Rapid Heating Rapid Cooling Sterilization” (ARHRCS). Thus, it can be used in Heating, Ventilation, and Air Conditioning (HVAC) systems in hospitals to produce safe air, free of pathogenic airborne microbes including bacteria and viruses such as tuberculosis (TB) and coronavirus (SARS-CoV-2). A crown fixed on the head of the medical staff may be connected to the HVAC system to produce a constant flow of clean laminar air. Hence, this crown is capable of keeping airborne microorganisms at a safe distance from Health Care Workers (HCWs), avoiding any potential microbial infection. Accordingly, HCWs will be able to work in more suitable and safe conditions, especially in high infection risk areas. Depending on its need, the newly developed process may be implemented in different other locations such as laboratories, malls, planes, buildings, and other crowded spaces. Further applications of this method may arise including its usage in the sterilization of recirculated air in biosafety cabinets and the development of a portable air sterilizing unit.
Pengaruh Perilaku Berpacaran Terhadap Perilaku Seksual Pranikah Pada Remaja Perempuan Indonesia
Authors: Mukminun Annur
Published: March 2022

Usia remaja merupakan usia diaman terjadi berbagai macam perubahan seperti fisik, kognitif, psikologis serta sosial. Penelitian terdahulu menunjukkan remaja rentan terpapar perilaku tidak sehat, salah satunya adalah perilaku seksual. Penelitian ini bertujuan untuk melihat pengaruh perilaku berpacaran terhadap perilaku seksual pranikah di masa remaja wanita di Indonesia. Penelitian ini merupakan penleitian kuantitatif analitik observasional. Data yang digunakan adalah data sekunder dari SDKI (Survei Demografi Kesehatan Indonesia) 2017. Analisis data meliputi analisis deskriptif dan analisis bivariat menggunakan uji chi-square yang kemudian dilanjutkan denagan analisis multivariat menggunakan uji regresi logistik. Pada hasil uji tabulasi silang didapatkan remaja yang berstatus berpacaran lebih banyak melakukan kontak fisik dengan pasangan dibandingkan dengan yang berstatus tidak berpacaran. Hasil yang sama didapatkan pada variabel hubungan seksual pranikah. Remaja yang berstatus berpacaran serta pernah melakukan perilaku kontak fisik seperti berpegangan tangan, berpelukan, berciuman bibir dan meraba bagian sensitif lebih banyak proporsinya yang pernah melakukan hubungan seksual. Didapatkan hubungan antara perilaku berpacaran terhadap perilaku seksual pranikah di masa remaja wanita di Indonesia. Dalam penelitian ini, perilaku seks pranikah berhubungan erat dengan intensnya gaya berpacaran remaja yang melibatkan kontak fisik. Perlu adanya intervensi bagi remaja terkait edukasi seks untuk mencegah timbulnya resiko akibat perilaku seksual yang tidak diinginkan.
Hubungan Antara Lingkungan Belajar Dengan Kelelahan Siswa SMA Di Kota Surabaya
Authors: Darma Hadyan Adi
Published: March 2022

Kelelahan pada siswa disebabkan oleh banyak faktor contohnya adalah lingkungan belajar yang dipilih pada siswa. Pada faktanya siswa SMA di Surabaya  siswa memiliki lingkungan belajar yang kurang aktif seperti sering membolos, tidak memperhatikan saat pembelajaran, malas-malasan untuk belajar dan lain-lain maka otomatis  motivasi dan semangat siswa untuk belajar kurang sehingga siswa  akan mudah jenuh dan lelah untuk belajar. Peran orang tua dalam lingkungan fasilitas pada siswa juga kurang, fasilitas yang dimiliki siswa SMA di Surabaya rata-rata masih kurang. jika fasilitas sudah lengkap dan memadai maka siswa juga akan semangat dan memiliki motivasi yang tinggi untuk belajar. Penelitian ini bertujuan untuk mengetahui hubungan antara lingkungan belajar siswa dengan kelelahan siswa kelas XII SMA/sederajat tahun ajaran 2020/2021 di Kota Surabaya. Metode yang digunakan dalam penelitian ini adalah pendekatan kuantitatif dengan jenis cross sectional . Populasi dalam penelitian ini adalah siswa kelas XII SMA/sederajat di Kota Surabaya. Penentuan sampel menggunakan teknik simple random sampling. Sampel dalam penelitian ini sebanyak 212 siswa. Metode pengumpulan data dalam penelitian adalah metode angket. Hasil uji analisis statistik menggunakan Fisher’s Chi Square. Hasil penelitian menunjukkan ada hubungan antara lingkungan belajar dengan kelelahan siswa kelas XII SMA/sederajat tahun ajaran 2020/2021 di Kota Surabaya. Besarnya hubungan dilihat dari uji Fisher’s Chi Square dan terdapat hubungan positif antara variabel lingkungan belajar dengan kelelahan sebesar 0,039 dengan  0,05. Nilai p < ,sehingga Ho ditolak.Kesimpulan dari penelitian ini adalah dari 212 siswa mengalami kelelahan yang dikategorikan sedang.Pada hasil uji analis statistik menunjukkan terdapatnya hubungan antara lingkungan belajar dengan kelelahan  yang dialami siswa.
Hubungan Keterpaparan Informasi Kesehatan Reproduksi dengan Perilaku Pencegahan Keputihan Santriwati PP. Amanatul Ummah Surabaya.
Authors: Salsabila Zahrotan Nuur
Published: March 2022

Kesehatan organ reproduksi merupakan hal yang penting juga menjadi fokus dalam pembangunan kesehatan dan salah satu masalah kesehatan terutama pada organ genetalia adalah terjadinya Fluor albus. Di Jawa Timur, remaja yang mengalami keputihan sebesar 75% dan masih dianggap bukan hal yang serius dikalangan santriwati PP. Amanatul Ummah Surabaya, minimya keterpaparan informasi kesehatan reproduksi dari sumber yang akurat sering menjadi persoalan padahal dampak dari penyakit yang memiliki gejala keputihan yang abnormal sangat berbahaya bagi organ reproduksi. Penelitian ini bertujuan untuk mempelajari hubungan antara keterpaparan informasi kesehatan reproduksi dengan perilaku pencegahan keputihan pada santriwati PP. Amanatul Ummah Surabaya. Desain penelitian yang digunakan adalah penelitian analitik dengan desain studi cross sectional. Populasi dan sampel pada penelitian ini adalah seluruh santriwati Madrasah Tsanawiyah PP. Amanatul Ummah Surabaya sebanyak 31 orang. Analisis data menggunakan software SPSS versi 22. Hasil penelitian menggunakan uji Chi-Square dengan tingkat kemaknaan α = 0,05 didapatkan nilai ρ = 0,831. Hal ini berarti ρ > α, maka H0 diterima yang artinya tidak ada hubungan antara keterpaparan informasi kesehatan reproduksi dengan perilaku pencegahan keputihan pada santriwati PP. Amanatul Ummah Surabaya.
Analisis Masalah Penyakit Menular Prioritas Di Provinsi Sulawesi Tengah
Authors: Rizaldi Mohamad , Wahyono Tri Yunis Miko , Suardiyasa I Made
Published: March 2022

Provinsi Sulawesi Tengah masih menghadapi masalah penyakit endemis seperti Sistosomiasis serta KLB yang rutin terjadi menambah permasalahan penyakit menular. Penelitian ini bertujuan untuk mengidentifikasi dan menentukan masalah penyakit menular prioritas serta penyebab penyakit menular prioritas. Penelitian ini dilakukan pada bulan Desember 2020 hingga Februari 2021 di Dinas Kesehatan Provinsi Sulawesi Tengah. Penelitian ini merupakan studi deskriptif dengan pendekatan kuantitatif dan kualitatif dengan mereview profil kesehatan tahun 2015-2019 dan data terkait lainnya. Prioritas masalah menggunakan metode PAHO-Adapted-Hanlon dan analisis penyebab masalah prioritas menggunakan metode Root Cause Analysis. Hasil Identifikasi masalah penyakit menular di Provinsi Sulteng yaitu CNR TB 220/100.000 penduduk dengan CFR 3,5%. Kasus HIV sebanyak 1811 kasus dan AIDS sebanyak 913 kasus dengan CFR 7%. Prevalensi Kusta 0,83/100.000 penduduk. Cakupan penemuan kasus pneumonia balita hanya 55,3% dengan CFR 0,12%, IR diare 17,3/1000 penduduk. API Malaria sudah mencapai  0,04/1000 penduduk. Kasus GHPR 3461 kasus dengan kasus Rabies Lyssa 8 kasus. IR Filariasis 6,3/100.000 penduduk dengan CFR 2,1%. PR Sistosomiasis pada manusia 0,1% sedangkan pada keong 2,5%. Hanya 1 kasus difteri yang ditemukan, terdapat 5 kasus Rubella dan  tidak ada kasus campak. AFP rate 2,17/100.000 penduduk. Dari uraian tersebut, prioritas masalah penyakit menular di Provinsi Sulawesi Tengah yaitu Tuberkulosis (skor: 35,7), Rabies (Skor: 26,2) dan Demam Berdarah Dengue (Skor:24,5). Diharapkan dapat meningkatkan angka penemuan kasus TB dan jumlah layanan TB-RO, meningkatkan jumlah rabies center dan pengetahuan masyarakat terkait rabies serta meningkatkan kesadaran masyarakat terkait PSN.
Manajemen Pos Kesehatan Pesantren Di Pondok Pesantren Modern Al-Ikhlas Kabupaten Polman
Authors: Djalaluddin Nurgadima Achmad , Al-Hijrah Muh Fauzar , Heriyati Heriyati
Published: March 2022

Pondok Pesantren adalah salah satu bentuk lembaga pendidikan keagamaan yang tumbuh dan berkembang dari masyarakat yang berperan penting dalam pengembangan sumberdaya manusia. Pos Kesehatan Pesantren, yang umumnya disebut Poskestren merupakan salah satu wujud Upaya Kesehatan Bersumber Masyarakat (UKBM) di lingkungan pondok pesantren, dengan prinsip dari, oleh dan warga pondok pesantren, yang mengutamakan pelayan promotif dan preventif tanpa mengabaikan aspek kuratif dan rehabilitatif , dengan binaan puskesmas setempat. Tujuan penelitian ini untuk menganalisis manajemen poskestren di Pesantren Moderen Al-Ikhlash. Penelitian ini menggunakan pendekatan kualitatif dimana dalam penelitian yang dilakukan bersifat deskriptif yaitu untuk mengetahui atau menggambarkan kenyataan dari kejadian yang diteliti sehingga memudahkan penulis untuk mendapatkan data yang objektif dalam rangka mengetahui pelaksanaan manajemen pos kesehatan pesantren. Jumlah Informan sebanyak 9 orang, yang terdiri dari guru, petugas poskestren dan santri. Hasil penelitian menunjukkan adanya kebijakan yang dibuat terkait pelaksanaan kegiatan poskestren seperti pelayanan santri yang sakit dan pengadaan fasilitas poskestren. Fungsi manajemen juga telah dilakukan oleh poskestren mulai dari perencanaan hingga evaluasi. Selain itu juga dilakukan rencana tidak lanjut pengembangan poskestren seperti penambahan jumlah gedung dan tenaga kesehatan tetap poskestren. Kesimpulannya adalah manajemen poskestren sudah berjalan dengan baik, dilihat dari kebijakan, manajemen, hingga rencana tindak lanjut untuk pengembangan poskestren namun masih perlu ada beberapa perbaikan dalam manajemen poskestren seperti masih kurangnya fasilitas poskestren dan kurangnya tenaga kesehatan tetap poskestren
A novel measurement method for the mixing of binary mixtures in three-dimensional fluidized beds
Authors: Huang Jikai , Lv Mingming , Duan Lian , Ji Can , Liu Zhigang
Published: March 2022

A novel measurement system for mixing property of binary mixtures in
three-dimensional fluidized beds is developed based on capacitance probe
method. The mixing processes at multi-positions of the bed are acquired
simultaneously. A new dispersion coefficient is proposed to characterize
the local dispersion of particles and a new mixing index is proposed to
evaluate the local mixing quality in three-dimensional fluidized beds.
The effect of convection and diffusion mechanism on particle mixing is
discussed separately. Results show that the governing mechanism of
particle mixing at the center and top of the beds is convection;
meanwhile the governing mechanism for particle mixing at the bottom and
near the wall is diffusion. The radial dispersion coefficient at the
half-radius of the bed is mainly between 0.0038 and 0.026 m2/s, which is
about 1.5 times that near the wall. The vertical dispersion coefficient
is about 2.5 times that the radial dispersion coefficient.
Bio-electric potentials in superior plants: electric collective behaviour
Authors: Chiolerio Alessandro , Dehshibi Mohammad Mahdi , Vitiello Giuseppe , Bernard Alessandro , Ceretto Paolo , Arvat Massimo , Adamatzky Andrew
Published: March 2022

Electrical activity is used by plants in long term signalling and
information transfer between the distant parts of the plant.
Biopotential recordings from trees in a natural environment have been so
far less discussed in scientific literature. Here we present our data
about the open science experiment TRee-hUMAn iNterface (TRUMAN) located
in Paneveggio forest (Valle di Fiemme, Trento, Italy), cultivated since
one thousand years for the production of harmonic wood from Picea
abies (red fir). We show that: i) biopotential features based on xylem
can be correlated with the solar (and lunar) cycle ii) dead tree logs
show an electrical activity that is correlated with that of neighbouring
trees iii) statistical features of the spike-like peaks are evidenced,
including amplitude, frequency, propagation speed, entropy iv) a quantum
field theory is presented to highlight the collective behaviour of the
forest, supported by preliminar correlation analyses between electrical
signal Kolmogorov entropy and thermographies Shannon entropy.
Biomarker potential of advanced glycosylated end-products levels at birth in premature infants with bronchopulmonary dysplasia
Authors: Go Hayato , Ohto Hitoshi , Nollet Kenneth , Sato Kenichi , Miyazaki Kyohei , Maeda Hajime , Ichikawa Hirotaka , Chishiki Mina , Kashiwabara Nozomi , Kume Yohei , Ogasawara Kei , Sato Maki , Hosoya Mitsuaki
Published: March 2022

Background: Bronchopulmonary dysplasia (BPD) is the most common
morbidity complicating preterm birth. The soluble receptor for advanced
glycosylated end-products (sRAGE) is impilicated in the development of
various disease such as pulmonary diseases. The objectives of this study
were to evaluate the perinatal factors associated with serum sRAGE
levels at birth and to establish whether serum sRAGE levels at birth
could be potential biomarkers for BPD. Methods: A total of 124 subjects
included 84 preterm and 40 healthy infants were included in this study.
Among 84 infants born at less than 32 weeks were categorized into BPD
neonates (n=34) and non-BPD infants (n=50). The median serum sRAGE
levels in cord blood were measured using an enzyme-linked immunosorbent
assay. Results: There were significant positive correlations between
gestational age, birth weight, and serum sRAGE levels at birth. Among
preterm infants born at less than 32 weeks, serum sRAGE levels at birth
were significantly lower in infants with BPD than without. However,
serum RAGE levels were not associated with severity of BPD. Conclusions:
Serum sRAGE levels at birth were significantly correlated with BW and
GA. Furthermore, serum sRAGE levels at birth could serve as a biomarker
for predicting BPD, but not its severity.
The spectrum of Malignant and Non-malignant phenotype with Homozygous Mutation of PMS2 consistent with Constitutional Mismatch Repair Deficiency in an adolescent who underwent Bone Marrow Transplantation.
Authors: Leung Yuen Lo Yau , Vasconez Wilson , Alvarez Jessica , Sanati-Mehrizy Ali
Published: March 2022

Constitutional Mismatch Repair Deficiency (CMMRD) is caused by a
biallelic mutation on one of the four major mismatch repair (MMR) genes.
It is a rare autosomal recessive syndrome that predisposes to childhood
cancer. We present a 21-year-old African American with metachronous
non-Hodgkin lymphoma during childhood, bone marrow transplant due to
relapse, and stage IV duodenal adenocarcinoma as a young adult. His
original presentation merited CMMRD screening. As many chemotherapy
agents cause DNA damage and require an intact MMR system, early
diagnosis could have anticipated the lymphoma relapse due to drug
resistance and started timely screening for other malignancies.
On Essential g-Supplemented Modules
Authors: Nebiyev Celil , Ökten Hasan Hüseyin
Published: March 2022

Let M be an R-module. If every essential submodule of M has a
g-supplement in M, then M is called an essential g-supplemented (or
briefly eg-supplemented) module. If every essential submodule has ample
g-supplements in M, then M is called an amply essential g-supplemented
(or briefly amply eg-supplemented) module. In this work, some properties
of these modules are investigated. It is proved that every factor module
and every homomorphic image of an amply eg-supplemented module are amply
eg-supplemented. Let M be a projective and eg-supplemented module. Then
every finitely M-generated R-module is amply eg-supplemented.
Neutrophil-to-Lymphocyte Ratio and Ferritin as Measurable Tools for Disease Burden and B Symptoms in Pediatric Patients with Hodgkin Lymphoma
Authors: Jan Saja , Mustafa Omima , Elgaml Amal , Ahmed Nehal , Abbas Adil , Althubaiti Sami
Published: March 2022

Background Pediatric Hodgkin lymphoma (HL) has been treated successfully
with risk- and response-adapted therapy. While all these risk factors
are measured objectively, B symptoms are subjective tools. We evaluated
whether the neutrophil-to-lymphocyte ratio (NLR) and inflammatory marker
levels correlated with B symptoms and disease burden. Methods The
medical charts of all children ≤14 years old with HL were
retrospectively reviewed. Data included, clinical and pathological
features, pretreatment ESR, ferritin levels; monocyte, neutrophil, and
lymphocyte counts; and NLR. Optimum cutoffs of variables significantly
associated with B symptoms were determined based on receiver operating
characteristic curves. Results Sixty-four patients were included in the
analysis. Sixteen patients (25%) had B symptoms. Patients with B
symptoms had higher ferritin levels (p<0.0001), monocyte
counts (p=0.0060), neutrophil counts (p=0.0003) and NLR (p
<0.0001) and lower lymphocyte counts (p=0.0017). Multiple ROC
curves were generated to identify the optimum cut-off. The sensitivities
and specificities of NLR (cut-off, 3.5) and ferritin (cut-off, 173
ng/ml) were highest [81.25% and 81.25% (p<0.0001) and
89.36% and 75% (p<0.0001), respectively]. Patients with
NLR >3.5 and ferritin>173 (ng/ml) had
significantly higher stage, bulky disease, and B symptoms. There was no
association between NLR and ferritin with disease outcome. Conclusions
NLR and ferritin levels were associated with high disease burden and B
symptoms. Therefore, these variables can be used as measurable tools for
B symptoms that can help stratify patients with HL. Larger and
prospective studies are needed to validate these findings.
On new generalized quantum integrals and related Hermite-Hadamard inequalities
Authors: KARA Hasan , BUDAK Hüseyin , alp necmettin , Kalsoom Humaira , Sarikaya Mehmet Zeki
Published: March 2022

In this article, we introduce a new concept of quantum integrals which
is called $^{\kappa_{2}}T_{q}$-integral.
Then we prove several properties of this concept of quantum integrals.
Moreover, we present several Hermite-Hadamard type inequalities for
$^{\kappa_{2}}T_{q}$-integral by utilizing
differentiable convex functions. The results presented in this article
are unification and generalization of the comparable results in the
literature.
Codon Pair Optimization (CPO): an algorithm and software tool for synthetic gene design based on codon pair bias in Pichia pastoris
Authors: Huang Yide , Lin Ting , Lu Lingfang , Chen Yajuan , Lin Jie , Jiang Yu'e , Lin Yao
Published: March 2022

Codon optimization of foreign genes is a common method to improve
protein expression level in Pichia pastoris and the current strategy
usually is to replace rare codons with preferred codons to match the
codon usage bias. However, codon-pair contexts have a profound effect on
translation efficiency in Pichia pastoris by influencing both
translational elongation rates and accuracy. Until now, it remains
untested in Pichia pastoris whether optimized exogenous genes based on
codon pair bias results in higher protein expression levels compared to
codon usage bias. In this work, we developed Codon Pair Optimization
(CPO) which is a software tool to provide simple and efficient codon
pair optimization for synthetic gene design in Pichia pastoris. Two
reporters (MT1-MMP E2C6 and ADAM17 A9B8 scFvs) were employed to test the
effect of CPO optimization on their protein expression levels in Pichia
pastoris. The CPO optimized genes displayed significantly higher
expression levels compared to those based on codon usage bias,
suggesting CPO is an efficient tool for synthetic gene design for higher
heterologous protein expression in Pichia pastors.
Cortriatriatum due to very dilated coronary sinus associated with supra mitral ring
Authors: Khajali Zahra , mohammadi nasibeh , Kaviani Raheleh , Pouraliakbar Hamidreza
Published: March 2022

A 34 Year lady is decribed in whom a persistent left superior vena cava
impinged on the posterior wall of the left atrium that accompanied with
membrane at distal part of it’s impingement and producing subdivided
left atrium
Validating Scores Predicting Atrial Fibrillation(AF) Recurrence Post Catheter Ablation in Patients with Concurrent AF and Pulmonary Diseases
Authors: Bai Ying , Wang Zhenzhou , Zhang Gai-gai , Guo Shi-Dong , Rivera-Caravaca José Miguel , Wang Yue-Li , Jin Yuanyuan , Liu Yue
Published: March 2022

Objective Several scores were available for predicting atrial
fibrillation (AF) recurrence following radiofrequency ablation.
Exploring their differences in patients with concurrent AF and pulmonary
diseases (PDs) would be helpful for making AF treatment decisions.
Methods and Results From January 2008 to April 2015, 304 patients with
concurrent AF and PDs treated with catheter ablation were divided into 2
groups according to whether they experienced AF recurrence in our
centers. During a mean of 13.42-month of follow-up, factors correlating
with late AF recurrence included heart failure (HF) history,
(HR[hazard ratio]: 2.79, 95% CI [confidence interval]:
1.49-5.22, p=0.001), current smoking (1.73, 1.13-2.68, p=0.01) and early
AF recurrence (3.85, 95% CI: 2.62-5.66, p<0.001) according to
univariate Cox regression analysis. The BASE-AF2 score had higher
c-index than the MB-LATER, APPLE, CHADS2, CHA2DS2-VASc, CAAP-AF and
HATCH scores when compared using ROC curves analysis (all p <
0.05), and then confirmed by DCA, NRI and IDI. Conclusions The BASE-AF2
score had higher predicting values compared with the MB-LATER, APPLE,
CHADS2, CHA2DS2-VASc, CAAP-AF and HATCH scores when compared in patients
with concurrent AF and PDs.
Analytical properties for the fifth order Camassa-Holm (FOCH) model
Authors: Zhu Mingxuan , Cao Lu , Jiang Zaihong , Qiao Zhijun
Published: March 2022

This paper devotes to present analysis work on the fifth order
Camassa-Holm (FOCH) model recently proposed in [28]. Firstly, we
establish the local and global existence of the solution to the FOCH
model. Secondly, the infinite propagation speed is obtained, in other
words, when the initial data u0(x) has a compact support, the
corresponding solution u(x, t) does not have a compact x-support any
longer in its lifespan. Finally, we discuss the long time behavior of
the support of momentum density with a compactly supported initial data.
BIMEDIAN AND BIHARMONIC FUNCTIONS ON INFINITE NETWORKS
Authors: Venkatraman Madhu , Manivannan Varadharaj
Published: March 2022

In this article, we have discussed Bimedian and Biharmonic functions on
an infinite network. Also, we have proved the Discrete Riquier problem
in the setting of infinite networks.
Evaluating the appropriateness of antibiotic treatment of tonsillitis during COVID-19 in the North Wales primary healthcare setting
Authors: Li CHUNHEI , Ong Caitlin , Morris Anna , Woollons Isobel , Ashfaq Ahsan , Jagatia Rikesh
Published: March 2022

Background The COVID-19 pandemic has changed the face of primary care
delivery in the NHS. Consultations have largely moved from face-to-face
to remote, forcing practitioners to modify the ways in which they
deliver care to patients. Aim In this study, we aim to investigate the
appropriateness of antibiotic prescribing in tonsillitis, which is
typically guided by clinical findings, during the COVID-19 pandemic
Design and Setting: An observational quantitative analysis in the North
Wales primary care setting Method: Retrospective review of computer
records across five GP centres from March 2020 until end of October
2020. Data was extracted and analysed using chi-square or fisher exact
rank and Man-Whitney test. Results Our results have shown no significant
difference in antibiotic prescribing behaviour comparing face-to-face
and remote consultations. Conclusion Remote consultation is as effective
as face-to-face consultation with regards to the assessment of
tonsillitis and the appropriateness of antibiotic prescription in
primary care.
HLA-G is highly expressed in the serum of patients with adenomyosis
Authors: yunkai xie , Wei Liu , Yonghui Zou , Fei Wang , Changzhong Li
Published: March 2022

Objective To evaluate the expression of soluble human leukocyte antigen
G(sHLA-G) in serum of patients with adenomyosis.Methods 34 patients with
adenomyosis and 31 patients with uterine fibroids diagnosed
histologically were selected as subjects. Serum SHLA-G expression level
was detected by enzyme-linked immunosorbent assay (ELISA) in patients
with adenomyosis and adenomyoma before and after treatment. while CA125
levels were determined using electrochemiluminescence immunoassay.
Results The preoperative serum sHLA-g expression level of the
adenomyosis group was significantly higher (18.53 ± 1.435 ng/ml) than
that of the fibroids group (28.05 ± 2.466 ng/ml) (P < 0.05).
The CA125 level was also significantly higher in patients with
adenomyosis than in controls (18.59 ± 1.673 VS 134.8 ± 30.41U/ml; P
< 0.05). Serum sHLA-G level in adenomyosis group showed a
decreasing trend before and after operation（28.05±14.38
ng/ml、18.41±8.34 ng/ml、14.45±5.77 ng/ml）, serum HLA-G level decreased
significantly at 2 days after surgery compared with that before surgery
(P < 0.05). sHLA-G decreased more significantly in patients
with adenomyosis who underwent total hysterectomy (n=20) than in those
who underwent partial hysterectomy (n=14), the sHLA-g level of the
patients who underwent total hysterectomy (16.04±4.27ng/ml) was
significantly lower than that of the patients who underwent partial
hysterectomy (21.79±11.35 ng/ml)(P<0,05).Conclusion Serum
sHLA-G is highly expressed in patients with adenomyosis and showed a
positive and significant response to therapy. Suggesting that sHLA-G may
be closely related to the immune tolerance process of adenomyosis, and
is expected to be a serological marker for prognosis assessment of
adenomy.
Should a biopsy be obtained prior to surgery in children with pancreatic masses? A case report describing the difficult journey of an adolescent undergoing treatments for a rhabdomyosarcoma of the head of the pancreas following primary pancreaticoduodenectomy for a suspected solid pseudopapillary tumor
Authors: Prud'homme Nicolas , Galante Gary , Kaur Harmeet , Brundler Marie-Anne , Beaudry Paul , Strother Douglas R.
Published: March 2022

Pancreaticoduodenectomy, a procedure rarely performed in children, can
lead to significant morbidity. Rhabdomyosarcoma is the most frequent
soft tissue sarcoma in pediatrics. Treatment consists of chemotherapy,
while local control can be achieved through either surgery, radiotherapy
or both. In this brief report, we describe the case of a 15-year-old
adolescent who underwent a pancreaticoduodenectomy for a presumed solid
pseudopapillary tumor of the head of the pancreas, ultimately diagnosed
as a fusion-positive rhabdomyosarcoma. We review the ensuing severe side
effects of the treatments, and discuss the role of biopsies for
pancreatic tumors in pediatrics.
Repercussion of Covid-19 Pandemic on the Blue Economy of
Authors: Mishra Rajani Kanta
Published: March 2022

Blue economy comprises about 4.1% of India’s economy of GDP. At present
the GDP has declined to 24%, a matter of concern during a Covid-19
pandemic. Hence, the study would appeal to the readership of the Policy
holders, Stakeholders, Local Government, Government of India for
considering necessary action plan towards the maintainable utilization
of ocean resources and sustainable management of Ocean resources and
tourism beneath this blue economy through various awareness programs and
measures to develop up to pre pandemic level with vigilance of Covid-19
pandemic. A comprehensive plan by the Indian government to setting up
regulatory reform to provide an empowering climate for a sustainable
ocean economy (e.g., comprehensive, integrated ocean management) and
marine spatial planning (MSP) processes and shift harmful subsidies to
more sustainable and equitable uses
Severe COVID-19 pneumonia associated with transient complete heart block and myocarditis: A case report
Authors: Devi Sujata , Kar Nilanjan , Bhuniya Sourin , Behera Anupama , Kapardar Bigyan
Published: March 2022

A 70-year-old male presented with complaints of fever for 10 days;
associated with dry cough for one week, gradually progressive shortness
of breath for five days, and non-radiating chest pain for three days.
Chest examination revealed bilateral basal crepitation, and cardiac
examination showed muffled first heart sound with soft systolic murmur
at apex. All severity markers of COVID-19 were elevated. Twelve lead
electrocardiography (ECG) showed complete heart block. Troponin-I test
was negative. High resolution computed tomography (HRCT) thorax showed
extensive bilateral multifocal patchy and confluent areas of
ground-glass opacities distributed along with peripheral subpleural and
peribronchovascular regions with interlobular septal thickening
suggestive of viral pneumonia .He was started on high flow oxygen,
parenteral corticosteroids, and anticoagulants with antibiotics
coverage. Injection Isoprenaline infusion was started for heart block,
but the patient developed atrial flutter-fibrillation with premature
ventricular complexes. The patient clinically improved and was
discharged on the 11th day of admission. On follow up after 2 weeks,
repeat ECG showed atrial fibrillation, and 2D Echocardiography revealed
global hypokinesia, severe mitral regurgitation with left ventricular
systolic dysfunction (ejection fraction of 28%), and dilated left
ventricle and atrium. He was planned for coronary angiography after one
month. High clinical suspicion, early diagnosis, and prompt treatment
with corticosteroids can yield a favorable outcome. Follow up is
necessary to rule out long term complications like viral cardiomyopathy.
Serum sST2 Correlates with Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Radiofrequency Ablation
Authors: fan jiali , li yuan , yan qing , wu wenhuan , xu pan , liu lu , luan chunhong , Zheng Qiangsun , xue jiahong
Published: March 2022

Objective: The present study was aimed to determine whether serum
sST2，could be used as a marker of left atrial low voltage areas (LVAs)
and it could be predicted the recurrence of AF in patients undergoing
radiofrequency catheter ablation. Methods:84 cases (average age 64.24 ±
10.17, including 54 paroxysmal AF and 30 persistent AF ) undergoing
radiofrequency ablation were finally included in the study.
Electroanatomical voltage mapping was employed to determine the extent
of left atrial low-voltage. LVAs were defined as bipolar electrogram
amplitudes ≤0.5 mV during sinus rhythm. The general clinical data and
hematological indexes of all patients were collected before ablation.
All patients were followed up at 3, 6 and 12 months after RF procedure.
Results: The primary outcome was sST2 could be used as a marker for the
left atrial low voltage area (OR = 1.054, P < 0.05), and the
serum level of sST2 had predictive value for the recurrence of AF after
RFA (HR 1.014, 95% CI 0.986-1.035, P = 0.035). It was showed that there
was 95% AF-free survival after ablation in the lower levels of serum
sST2 whereas there was only 59.6% AF-free survival in the higher levels
of serum sST2 according to the subgroup analysis. (Log Rank test,
P=0.027). The secondary outcome was that serum sST2 combined with left
atrium ateroposterior diameter (LAD) can further improve the prediction
ability. Conclusions:sST2 may be a new biomarker in the assessment of
atrial fibrosis and is associated with the recurrence of atrial
fibrillation after radiofreqency ablatation.
Phylogenetic and pathogenicity analysis of a novel lineage of caprine parainfluenza virus type 3
Authors: Ma Yanhua , Wang Yan , Zan Xiaohui , Wu Youzhi , WANG Jialei , Li Gairu , Chai chunxia , Fu Cun , Wang Shirong , Yin Hua , Wang Wei
Published: March 2022

Caprine parainﬂuenza virus type 3 (CPIV3) was first identified in goats
named JS2013 in China. In 2019, a sheep herd broke a disease with
respiratory disease in Hebei province, China. In order to confirm the
pathogen of the disease, the nasal swabs, stool swabs and blood samples
were collected from the sheep. Virus isolation was performed on MDBK
cells and identification was conducted by RT-PCR. The complete genome of
the isolate was sequenced and phylogenetic analyzed. In order to
evaluate the pathogenicity of the virus, five seronegative sheep were
experimental infected with the virus suspension. The phylogenetic
analyses based on the complete genome and the M gene indicated that the
isolate strain was distinguished distinct from previously reported CPIV3
lineage of JS2013. The virus-inoculated sheep displayed the syndrome
with depression, cough, and fever. Virus shedding were detected by
RT-PCR from nasal swabs. All infected showed virus shedding during 2 -
21dpi and viremia could be detected in serum samples. Gross pathological
assessment of sheep in infected group showed gross lesion in the lungs.
Histopathological observation results indicated that lungs had mild to
moderate interstitial pneumonia , with thickened alveolar walls,
decreased alveolar space, and increased amounts of inflammatory cells
infiltration. This is the first report of pathogenicity of the novel
lineage of sheep-derived CPIV3. The results would be helpful for further
studies on the prevention and control strategies for CPIV3 infections in
goat and sheep.
Heat stress on maize with contrasting genetic background: Differences in flowering and yield formation
Authors: Liu Mayang , Zhang Yingjun , Gu Mingqi , Yu Yonghong , Xie Hejing , Yang Hua , Yu Xueyuan , Dong Xing , Huang Shoubing
Published: March 2022

Maize grain yield greatly reduces when subjected to heat stress around
flowering and early grain filling, but the responses of temperate (Te)
and tropical (Tr) maize genotypes to heat are unclear. For this, 162
maize inbred lines with Te, Tr and Te×Tr were grown at six sowing dates
over four years of 2015 – 2018. Yield reduction was mainly a function
of low kernel number under heat stress. Kernel number on average reduced
by 73-98% under heat stress around flowering, with Tr inbred lines
having significantly smaller reductions than Te and Te×Tr inbred lines.
Kernel number reduction of Te, Tr, and Te×Tr varied largely in heat
stress, indicating there are both heat sensitive and tolerant inbred
lines in each group. Tr inbred lines on average maintained a lower
flowering – time plasticity than Te inbred lines. Post-silking growth
in a short period of approximately two weeks were most sensitive to
heat. Adjusting sowing date was a more effective strategy to reduce heat
impacts around flowering than genotypes, but sowing date and genotype
combined together only alleviated ~80% of negative
effects of heat stress on yield. Heat tolerant inbred lines used in this
study can be potential germplasm resource.
Emergence of phenotypically distinct subpopulations is a factor in adaptation of recombinant Saccharomyces cerevisiae under glucose-limited conditions
Authors: Wright Naia , Wulff Tune , Workman Christopher , Rønnest Nanna , Sonnenschein Nikolaus
Published: March 2022

Cells cultured in a nutrient-limited environment can undergo adaptation,
which confers improved fitness under long-term energy limitation. We
have previously shown how a recombinant S. cerevisiae strain, producing
a heterologous insulin product, under glucose-limited conditions adapts
over time at the average population level. In this paper, we
investigated this adaptation at the single-cell level by application of
FACS and showed that three apparent phenotypes underlie the adaptive
response observed at the bulk level: (1) cells that drastically reduced
insulin production (23 %), (2) cells with reduced enzymatic capacity in
central carbon metabolism (46 %), (3) cells that exhibited pseudohyphal
growth (31 %). We speculate that the phenotypic heterogeneity is a
result of different mechanisms to increase fitness. Cells with reduced
insulin productivity have increased fitness by reducing the burden of
the heterologous insulin production and the populations with reduced
enzymatic capacity of the central carbon metabolism and pseudohyphal
growth have increased fitness towards the glucose-limited conditions.
The results highlight the importance of considering population
heterogeneity when studying adaptation and evolution.
The timing of thermal acclimation and its adaptive role to face heat impacts. An examination in tropical tadpoles
Authors: Gonzalez Jorge Turriago , Tejedo Miguel , Hoyos Julio Hoyos , Bautista Manuel Bernal
Published: March 2022

Phenotypic plasticity of the upper critical thermal limits (CTmax) may
be crucial for ectotherms when it enables them to respond rapidly to
extreme and novel thermal conditions. Although current studies have
widely reported on the effect of increasing temperature on the magnitude
of the plastic response of ectotherms, little is known about timing of
upper thermal acclimation. These temporal components may be adaptive and
of major environmental concern, especially under the increasing
frequency of episodic heatwaves, predicted by climate change models
together with quick habitat conversion. We experimentally studied the
temporal acquisition of a greater thermal tolerance by acclimation
effect in four species of tropical tadpoles, adjusting the daily
variation in the CTmax to an asymptotic function and analyzing its main
parameters: asymptotic CTmax (CTmax∞) and acclimation rate of the CTmax
(K), under two realistic daily thermal fluctuations: mean daily
fluctuation (MF) and extreme hot fluctuation (HF), and under the
corresponding constant temperatures, mean constant (MC) and hot constant
(HC). The rate of acclimation was higher for constant and hotter
conditions, with which the CTmax∞ was reached in a shorter time under
these conditions. The time to achieve the CTmax∞ was between one and
three days depending on the treatment of acclimation and species.
Plastic responses are species-specific and appear to be adaptive to the
level of thermal heterogeneity of their breeding environment.
Engystomops pustulosus tadpoles, that develop in hot and thermally
variable temporary pond had the greatest acclimation. This suggests that
species exposed naturally to extreme heat events may exhibit the highest
plastic response in acclimation to upper thermal tolerances.
Differentiable functions in a three-dimensional associative noncommutative algebra
Authors: Kuzmenko Tetiana , Shpakivskyi Vitalii
Published: March 2022

We consider a three-dimensional associative noncommutative algebra
Ã over the field C, which contains the algebra of
bicomplex numbers B(C) as a subalgebra. In this paper we consider
functions of the form
Φ(ζ)=f(ξ,ξ,ξ)I+f(ξ,ξ,ξ)I+f(ξ,ξ,ξ)ρ
of the variable
ζ=ξI+ξI+ξρ,
where ξ, ξ, ξ are
independent complex variables and f,
f, f are holomorphic functions of
three complex variables. We construct in an explicit form all functions
defined by equalities dΦ=dζ·Φ’(ζ) or dΦ=Φ’(ζ)·dζ. The obtained
descriptions we apply to representation of the mentioned class of
functions by series. Also we established integral representations of
these functions.
Double Risks, Double care
Authors: Jiao Jinyu , Liu Ming
Published: March 2022

Electrocardiogram (ECG) is the most readily available objective data
from patients, it contains a wealth of connotation, but rapid and
accurate identification of high risk ECG is still a challenge for most
practitioners. We present an interesting case with two types high risk
ECG patterns, de Winter like ECG pattern and J wave, which implied acute
occlusion of coronary artery and sudden cardiac death. The patient was
treated promptly and quickly (within 40 min, from first touch to
complete the operation), and the patient took a turn to be out of
danger.
Prediction of adverse pregnancy outcomes using crown-rump length at 11 to 13+6 weeks of gestation: a retrospective cohort study
Authors: Kwak Dong Wook , Yang Jeong In , Song Kwan Heup , Ryu Hyun Mee , Han You Jung , Kim Moon Young , Chung JinHoon
Published: March 2022

Objectives: To assess the risk of adverse pregnancy outcomes associated
with fetuses with a smaller or larger than expected crown-rump length
(CRL). Design: Retrospective cohort study Setting: A single center in
South Korea Population: A total of 960 healthy women who conceived after
in vitro fertilization. Methods: We constructed reference charts for CRL
measurements between 11 and 13+6 weeks of gestation according to the
gestational age. Small and large fetal CRLs were defined as CRLs below
the tenth and above the ninetieth centiles, respectively. Multiple
logistic regression was used to determine the risk of adverse pregnancy
outcomes associated with a small or large fetal CRLs. Main Outcome
Measure: Adverse pregnancy outcomes including preterm delivery, low
birth weight, smaller-than-gestational-age (SGA),
larger-than-gestational-age (LGA), macrosomia, and gestational diabetes.
Results: A smaller than expected CRL was associated with an increased
risk of SGA (adjusted odds ratio [aOR], 2.79; 95% confidence
interval [CI], 1.53–5.08; p < 0.001) and preterm delivery
before 34 gestational weeks (aOR, 6.48; 95% CI, 1.36–30.79; p =
0.019). A larger than expected CRL was associated with an increased risk
of LGA, even after adjustment for well-known risk factors of macrosomia
(aOR, 3.67; 95% CI, 2.04–6.59; p < 0.001), and a decreased
risk of gestational diabetes (aOR, 0.10; 95% CI, 0.01–0.76; p =
0.026). Conclusions: A larger than expected CRL at 11 to 13+6 weeks’
gestation is independently associated with the development of LGA
neonates and could be used as a predictor of excessive fetal growth.
Heat transfer analysis in entropy optimized Sutterby nanofluid flow over a porous medium
Authors: Rahman Mujeeb , Hayat T , Khan Sohail , Alsaedi Ahmed
Published: March 2022

In present communication irreversibility analysis in Sutterby nanofluid
flow towards stretching permeable surface is analyzed. Dissipation, heat
flux, heat source/sink and Joule heating impacts are scrutinized in
energy expression. Physical description of irreversibility analysis is
deliberated through second law of thermodynamics. Thermophoresis and
random movement characteristics are also accounted. Furthermore first
order binary chemical reaction is scrutinized. Ordinary differential
system are obtained through similarity transformation. To get convergent
series solution we employed ND-solve method. Prominent effect of
involved variables on velocity filed, entropy optimization, temperature
distribution, Bejan number and concentration are discussed. Skin
friction coefficient, gradient of temperature and Sherwood number are
numerically analyzed through tables. An increment in velocity field is
noted for Reynold and Deborah number. An opposite behavior for velocity
and temperature is noticed through magnetic parameter. Larger Schmidt
number reduces the concentration distribution. Entropy generation is
improved against Reynold and Brinkman numbers. An reverse trend is
observed for Bejan number and entropy rate through magnetic parameter
Compactness on bipolar soft topological spaces
Authors: (Aras) Cigdem Gunduz , Bayramov Sadi
Published: March 2022

It is the purpose of this paper to go somewhat deeper into the structure
of bipolar soft topological spaces. We shall introduce the concept of
bipolar soft compactness. By using bipolar soft sets, this situation it
furnishes us a basic tool to investigate the compactness in a more
general way. For compactness the hereditary property with respect to
bipolar soft closed subsets holds. So, bipolar soft compactness is a
good extension. The continuous images of bipolar soft compact sets are
bipolar soft compact. If bipolar soft topological space is bipolar soft
T₂-space, then it will satisfy a stronger separation axiom which will be
called bipolar soft normal space in tis paper. Lately for bipolar soft
compactness, the Tychonoff product theorem holds.