bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of ANRIL Polymorphisms on Colorectal Cancer, Tumor Stage, and Tumor Grade among Iranian Population
Authors: Asadi-Tarani Mina , Darashti Ahmadreza , Javadi Mohammadsaeid , rezaei Mahnaz , Saravani Mohsen , Salimi Saeedeh
Published: November 2023

Background: Colorectal cancer (CRC) is a type of neoplasm, developing in the colon or rectum. The exact etiology of CRC is not well known, but the role of genetic, epigenetic, and environmental factors are established in its pathogenesis. Therefore, the aim of this research was to explore the effects of ANRIL polymorphisms on the CRC and its clinical findings.
Methods and Results: The peripheral blood specimens were collected from 142 CRC patients and 225 controls referred to Milad Hospital, Tehran, Iran. PCR- RFLP method was used to analyze ANRIL rs1333040 rs10757274, rs10757274 and rs1333048 polymorphisms. The ANRIL rs1333040 polymorphism was related to a higher risk of CRC in the co-dominant, dominant, and log-additive models. ANRIL rs10757274, rs10757274, and rs1333048 polymorphisms showed no effect on CRC susceptibility. Haplotype analysis showed a higher risk of CRC in individuals carrying the CGAA haplotype of ANRIL rs1333040/ rs10757274/ rs4977574/rs1333048 polymorphisms and a lower risk of TGGA haplotype compared to TGGC haplotype. The rs1333040 polymorphism was associated with higher TNM stages (III and IV). ANRIL rs10757274 polymorphism was lower in CRC patients over the age of 50 years only in the dominant model. In addition, the rs10757274 was associated with well differentiation in CRC patients.
Conclusion, The ANRIL rs1333040 polymorphism was associated with a higher risk of CRC and higher TNM stages. ANRIL rs10757274 polymorphism was associated with the well-differentiated tumor in CRC.
An evaluation of first responders' intention to refer to post-overdose services following SHIELD training
Authors: Siddiqui Saad Tariq , Manna Anna La , Connors Elizabeth , Smith Ryan , Vance Kyle , Budesa Zach , Goulka Jeremiah , Beletsky Leo , Wood Claire A , Marotta Phillip , Winograd Rachel P.
Published: November 2023

Background
First responders (law enforcement officers [LEO] and Fire/Emergency Medical Services [EMS]) can play a vital prevention role, connecting overdose survivors to treatment and recovery services. This study was conducted to examine the effect of training on first responders’ intention to refer overdose survivors to treatment, syringe service, naloxone distribution, social support, and care-coordination, and whether the outcome differed by first responder profession.
Methods
First responders in Missouri were trained using the SHIELD (Safety and Health Integration in the Enforcement of Laws on Drugs) model. Trainees’ intent to refer (ITR) overdose survivors to prevention and supportive services was assessed pre- and post-training (1–5 scale). Trainees were also asked if they ever witnessed an overdose fatality. Mixed model analysis was conducted to assess change in mean ITR scores between pre- and post-training, and between profession type, while adjusting for random effects between individual trainees and baseline characteristics.
Results
Between July 2020 and January 2023, 742 first responders completed pre- and post-training surveys. SHIELD training was associated with first responders’ intention to refer, increasing overall ITR to any type of support service from 2.30 (± 0.99) to 3.90 (± 0.99), with ITR to naloxone distribution (1.83 to 3.88) and syringe exchange (1.73 to 3.69) demonstrating the greatest changes. There was a significant increase in ITR score from pre- to post-test (β = 2.15; 95% CI: 1.99, 2.30), and LEO had a higher score than Fire/EMS (0.509, 95% CI = 0.367, 0.651).
Conclusion
Training bundling occupational safety with harm reduction content is immediately effective at increasing first responders’ intention to connect overdose survivors to community substance use services. When provided with the rationale and instruction to execute referrals, first responders are amenable, and their positive response highlights the opportunity for growth in increasing referral partnerships and collaborations. Further research is necessary to assess whether ITR translates to referral behavior in the field.
Co-designing a Personalised Care Plan for patients with rectal cancer: reflections and practical learnings
Authors: Gard Grace , Oakley Jo , Serena Kelsey , Gough Karla , Harold Michael , Gray Katya , Anderson Helen , Byrne Judi , Cockwill Jo , Down Graeme , Kiossoglou George , Gibbs Peter
Published: November 2023

Background: Consumer involvement is considered an essential component of contemporary cancer research, with a movement towards participatory methods, to the benefit of consumers and researchers. Overall, in-depth research on participant experiences and perceptions of their co-designer role—and how these may (or may not) change during a co-design project—is limited. The purpose of this paper was to synthesise the reflective accounts of cancer consumers, project staff, and a researcher who partnered on a project to develop a personalised care plan template, with the aim of generating guidance for others looking to partner with consumers in health and medical research.
Here, our team of researchers, project staff, and consumers reflect on the experience of working together using Gibbs’ Reflective Cycle, which was completed by team members with responses then undergoing inductive data analysis.
Results: Reflections are categorised under three core themes: (1) setting up the group and building relationships (2) measuring the value of consumer involvement, and (3) potential challenges for consumer involvement. Through reflection on our experiences of co-design, our team developed and identified practical strategies that contributed to the success of our partnership. These include setting expectations as a group; having experienced consumers on the team; having regular, pre-scheduled meetings that run to time; and working to overcome challenges identified by the group such as power imbalances, time commitment, and lack of diversity.
Conclusion: These practical reflections on creating a safe and supportive environment in which genuine consumer involvement can take place could inform other institutions and researchers looking to work meaningfully with consumers in research.
An aerosol barrier system as an emerging technology for reducing airborne pathogens during singing
Authors: Karam Karam Abi , Forzani Fernando R. , Mora S. Jimena , Pyznar Gabriel , Velasquez Joseph , Elghoul Anthony Ziad , Patel Bavesh , Lowell Amelia , Forzani Erica , Schildkret David
Published: November 2023

In the initial stages of the COVID-19 pandemic, it became evident that singing carried a substantial risk of virus transmission. Consequently, new regulations were implemented to safeguard the population, and the adoption of singing masks emerged as a pivotal measure to curb the spread of COVID-19 during vocal performances. However, the discomfort and impediment to sensory expression caused by these masks posed significant challenges, particularly for individuals whose passions or professions revolved around singing. This study shows a novel solution to address these issues: the Aerosol Barrier System for Singing. The system features a transparent screen with an Impactor-Fan-Filter. The Impactor-Fan-Filter (IFF) is integrated into the transparent screen and strategically positioned within 1.5 feet of the singer's face. We demonstrated that the system effectively reduces the dispersion of aerosols generated during singing by over 99%. In addition, comparative sound analysis indicated that the system minimizes interference with sound waves, ensuring the preservation of sound quality. Furthermore, the transparent screen offers an unobstructed view of the singer, enhancing the overall performance experience. Our system adheres to several crucial criteria for an effective solution tailored to the needs of singers: it prioritizes safety and comfort, upholds sound quality, and facilitates an unrestricted view of the singer's entire face for the benefit of the audience, conductors, and ensemble members.
A basaloid carcinoma with multilocular thymic cyst mimicking a mediastinal teratoma: A case report
Authors: Su Chen , Zhu Xiaobo , Wang Qiang , Zhang Junjie
Published: November 2023

Background: Thymic tumors pose diagnostic challenges, with basaloid carcinoma being a rare and elusive variant that can mimic other mediastinal masses.
Case presentation: We present a case of a 71-year-old female initially diagnosed with a mediastinal teratoma. Imaging displayed a cystic, calcified tumor with close proximity to vital structures, suggestive of a mediastinal teratoma. The patient underwent subxiphoid thoracoscopic mediastinal tumor resection, and postoperative pathology and immunohistochemistry revealed thymic basaloid carcinoma. Fortunately, the patient had no postoperative complications, and no signs of tumor recurrence or metastasis were found during the 3-month follow-up.
Conclusions: While thymic basaloid carcinoma is infrequent, its resemblance to mediastinal teratoma complicates diagnosis and treatment planning. As we accumulate cases, a collective analysis will enhance diagnostic precision and therapeutic approaches for these intricate malignancies.
Endocrine disruptors as promoters of biosphere carcinogenic background
Authors: Belitsky G. A. , Kirsanov K. I. , Lesovaya E. A. , Zhidkova E. M. , Khitrovo I. A. , Yakubovskaya M. G.
Published: November 2023

The main aim of the study is to analyze modern knowledge on endocrine disruptors, non-genotoxic carcinogens, contributing significantly to the total level of contamination of the biosphere by anthropogenic blastomogens.

Material and Methods. For the review preparation, we analyzed articles on molecular mechanisms of the effects of endocrine disruptors, available at biomedical literature databases sciVerse scopus, pubmed, Web of science, Rsci. The review cited 65 recent publications, 21 of them being published over the past three years, 3 papers being the official documents on hazards associated with the use of endocrine disruptors, and 10 papers presenting a background to separate endocrine disruptors into the group of compounds with specific functional activity.

Results. The role of endocrine disruptors involves the development of the tumors of reproductive organs. They may reveal the properties of strong agonists or antagonists disrupting the hormonal balance by inhibition of the synthesis of natural hormones, their secretion, transport, metabolism, binding or degradation. In addition, they activate alternative proliferation signaling pathways by activating g-proteincoupled receptors, estrogen-bound eRRγ or/and β-adrenergic receptors. The main mechanism of action of endocrine disruptors is the induction of epigenetic modifications, in particular, methylation/demethylation of cpg dNa islands, histone modifications and changes in expression of non-coding RNa. since the effects of endocrine disruptors are nonlinear, they can be caused by concentrations corresponding to the real content in the biosphere and detected in the umbilical blood and breast milk. In addition, they contribute to the metabolic activation of the procarcinogens, the main component of air pollution, by activation of the cytochrome p450 isoforms.

Conclusion. Endocrine disruptors can underlie the development of tumors of hormone-dependent organs both at direct and transplacental exposure.
Systemic lymphangitic carcinomatosis from unknown primary cancer mimicking lung disease in a new coronavirus infection (COVID-19): a case report
Authors: Andryukhova E. S. , Krakhmal N. V. , Tashireva L. A. , Vtorushin S. V. , Zavyalova M. V. , Perelmuter V. M.
Published: November 2023

lymphangitic carcinomatosis is characterized by the spread of cancer cells through pulmonary lymphatic vessels, which results in secondary interstitial inflammation. The diagnosis of lymphangitic carcinomatosis is challenging due to nonspecific clinical symptoms and radiological findings that similar to those of interstitial lung disease.

The purpose of the study was to demonstrate difficulties in the diagnosis of lymphangitic carcinomatosis with a systemic dissemination from unknown primary site. Case presentation. We report on a case of lymphangitic carcinomatosis from cancer of unknown primary origin with systemic involvement of internal organs imitating pulmonary disease caused by coVid-19. patient K., 58 years old, was treated for 12 bed-days in therapy departments with the diagnosis of bilateral viral coVid-19 pneumonia. clinical, laboratory and instrumental data were nonspecific. despite treatment, heart failure and kidney disease progressed to terminal stages, leading to the death of the patient. Autopsy revealed systemic lymphangitic carcinomatosis from cancer of unknown primary origin with involvement of the lungs, heart, liver, pancreas, spleen, kidneys and adrenal glands. lymphangitic carcinomatosis mimicked interstitial lung disease in a novel coronavirus infection coVid-19. metastasis to the heart mimicked coronary disease, and metastases to the kidneys led to acute kidney failure, which along with acute respiratory and heart failure caused the death of the patient.

Conclusion. lymphangitic carcinomatosis, which does not have specific clinical manifestations, is able to mimic interstitial lung diseases, including a new coronavirus infection. cancer of unknown primary and multiple visceral metastases in this case confirm the concept of the independence of different types of tumor progression.
Cancer care to the population of Russia in 2022
Authors: Shakhzadova A. O. , Starinsky V. V. , Lisichnikova I. V.
Published: November 2023

Objective: to analyze cancer statistics in Russia as a whole, as well as in individual regions of the Russian Federation.

Material and Methods. Based on data from the state medical statistics according to the form No. 7 “information on malignant neoplasms for 2022” the crude and standardized rates, standard error of crude and standardized rates, confidence intervals (ci) for 2022, and the qualitative parameters of cancer care were calculated.

Results. in 2022, 624,835 new cancer cases were detected in the Russian Federation (283,179 in men and 341,656 in women), in increase of 7.6 % compared to 2021 (in 2021: 580415), and decrease of 2.4 % compared to 2019 (in 2019: 640391). in 2022, the crude incidence rate was 425.89 ± 0.54 per 100,000 population of Russia (ci: 424.83–426.95 per 100,000 population), which was 7.0 % higher than that in 2021 (in 2021 – 397.91 ± 0.54 per 100,000 population) but 2.4 % lower than in 2019 (in 2019 – 436.34 ± 0.52 per 100,000 population). the standardized incidence rate was 236.47 ± 0.32 per 100,000 population (ci: 235.84–237.10 per 100,000 population), which was 5.2 % higher compared to that observed in 2021 (in 2021 – 224.87 ± 0.32 per 100,000 population) but 5.2 % lower than in 2019 (in 2019 – 249.54 ± 0.33 per 100,000 population). the prevalence rate of cancer in 2022 was 2,742.4 per 100,000 population of Russia, an increase in the prevalence rate over 10 years was 33.9 %.

Conclusion. Сancer care in the Russian Federation in 2022 was provided at the proper level. there is a positive trend in the early detection of cancer, which partly influences the reduction in the one-year mortality rate.
Minimally-invasive and non-invasive methods of thermal destruction in the treatment of patients with aggressive fibromatosis
Authors: Moskvicheva L. I.
Published: November 2023

The purpose of the study was to characterize various methods of local physical destruction used in the treatment of patients with aggressive fibromatosis and demonstrate international experience of their use.

Material and Methods. literature search was conducted in the electronic databases Rsci (Russian science citation index) and NcBi (National centre for Biotechnology information) in the interval time between 2002 and 2022. The review was devoted to the thermal ablation modalities (radiofrequency, microwave ablation, cryodestruction, high-intensity focused ultrasound ablations) used in therapy of patients with desmoid fibromas of various locations, as well as their safety and efficacy.

Results. The review presents the current data on safety and efficacy of minimally-invasive and non-invasive methods of hypo- and hyperthermic local destruction in patients with aggressive fibromatosis, gives the characteristics of exposure and biological effects when performing radiofrequency and microwave ablation, cryodestruction, high-intensity focused ultrasound therapy, describes the main limitations of the methods, indications and contraindications for their application, as well as the methods of prevention of the development of desmoid fibromas.

Conclusion. The described methods of local destruction are used in clinical practice mainly for palliative and symptomatic purposes, in case of persistent tumor growth or recurrence, ineffectiveness of other treatment options or contraindications to them due to concomitant somatic pathology or functional status of the patient. Inclusion of these methods in the treatment plan of patients with aggressive fibromatosis can contribute to the reduction of pain syndrome, improvement of functional status of patients as well as long survival with no evidence of tumor progression.
Hemophagocytic syndrome and coronary artery aneurysms in a child with Kawasaki disease
Authors: Makarova T. P. , Sadykova D. I. , Firsova N. N. , Sabirova D. R. , Kucheriavaia А. А. , Melnikova Yu. S. , Sergina A. V. , Sergina P. V. , Gimadieva A. I.
Published: November 2023

Mucocutaneous lymph node syndrome (Kawasaki syndrome/disease) is an acute systemic disease characterized by a predominant lesion of medium and small arteries (arteriitis), the development of destructive proliferative vasculitis. The most serious manifestations of Kawasaki disease are coronaritis and the formation of aneurysms of the coronary arteries, which can be a potential cause of acute coronary syndrome in children. The article presents our own clinical observation of a 7-month-old child with a complete form of Kawasaki disease with the formation of aneurysms of the coronary arteries, complicated by acute coronary and hemophagocytic syndromes. Kawasaki syndrome should be considered in all children with persistent fever ≥ 5 days, and the combination of persistent fever with 2–3 typical features of Kawasaki syndrome should be an absolute indication for echocardiography with mandatory visualization of the coronary arteries.
Recurrent eosinophilic esophagitis in an adolescent patient
Authors: Khakimova R. F. , Kamalova A. A. , Akhmatova Yu. M. , Tarasova D. E. , Poliakov N. S. , Khabibullina A. R. , Kuznetsova A. G.
Published: November 2023

Despite the availability of current Russian clinical guidelines for the management of eosinophilic esophagitis, this disease is a difficult diagnostic and therapeutic problem. The article presents a clinical observation of a teenager with recurrent eosinophilic esophagitis. The importance of clarifying the patient’s compliance with an emphasis on adherence to the regimen and the adequacy of the dose of the therapy used is emphasized. Despite the ongoing complex therapy administered to the patient with eosinophilic esophagitis, including an elimination diet, proton pump inhibitors and topical steroids, the patient has relapses of the disease, confirmed endoscopically and morphologically. The absence of a regulated duration of therapy with topical steroids, the need for endoscopic and morphological monitoring of the effectiveness of treatment also complicates the management of this group of patients.
Colonization resistance of buccal epitheliocytes as an indicator of mucosal immune homeostatic resources in children with recurrent respiratory diseases
Authors: Pikuza O. I. , Faizullina R. A. , Zakirova A. M. , Samorodnova E. A. , Volianiuk E. V. , Rashitova Е. L. , Yazdani E. V.
Published: November 2023

Of particular interest is the study of colonization resistance of the oral cavity as a physiological phenomenon that reflects the ability of the microbiota and macroorganism in cooperation to protect the ecosystem of the oral cavity from pathogens. Purpose is to evaluate the significance of indicators of colonization resistance of buccal epithelial cells as a marker of homeostatic resources of mucosal immunity in recurrent respiratory diseases in children. Material and methods. 232 (5–16 years old) children were examined, including 56 children with acute bronchitis, 73 with recurrent bronchitis, 103 with community-acquired pneumonia. The control group included 31 apparently healthy children of the same age and sex. Used: conventional paraclinical and laboratory-instrumental methods, etiological verification of viruses and bacteria, colonization index and artificial colonization of buccal epitheliocytes, antiadhesive activity of saliva. Results. 64.38% of children with recurrent bronchitis and 72.82% of children with community-acquired pneumonia were born from an aggravated pregnancy and already at 3 months had signs of acute respiratory diseases. Viral antigens were detected in 63.36% of children. An inverse relationship was found between the indicators of artificial colonization and adhesion of Candida albicans on buccal epithelial cells — the lower the values of artificial colonization, the more often pneumonia and recurrent bronchitis were recorded. A significant decrease in saliva antiadhesion was found in recurrent bronchitis and community-acquired pneumonia, significantly different not only from the control, but also from patients with acute bronchitis. This contingent of patients finds itself in extremely unfavorable conditions due to the disruption of the adaptive reserves of the mucosal defense of the body. Conclusion. A decrease in the index of colonization, antiadhesive activity of saliva against the background of increasing parameters of artificial colonization in children with recurrent bronchitis and community-acquired pneumonia indicate deep dysbiosis. The high significance of screening approaches in assessing the homeostatic resources of mucosal protection of the oral cavity in children with bronchopulmonary pathology has been proven.
Effects of drying methods on the biochemical and antioxidant properties of Volvariella volvacea from Côte d’Ivoire
Authors: Koffi Boidi Blaise , Gbotognon Oscar Jaures , Soro Songuimondenin , Kouadio Eugene Jean Parfait
Published: November 2023

The wild mushroom Volvariella volvacea is widely picked and consumed in Côte d’Ivoire. However, it is highly perishable due to its high moisture content. This study aimed to determine the effects of three drying methods on the biochemical and mineral composition, as well as antioxidant properties, of V. volvacea powders. Three V. volvacea powders were obtained by sun drying, oven drying, and freeze-drying. Each powder was analyzed for its biochemical and mineral composition according to standard analytical methods. The powder methanolic extracts were analyzed for their antioxidant components by colorimetric methods or titration, while their antioxidant capacities were determined by using DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) scavenging and the ferric reducing antioxidant power. The freeze-dried powder of V. volvacea had a better (lower) moisture content than the oven-dried and sun-dried powders. The highest protein, ash, and fiber contents were also recorded in the freeze-dried powder. In addition, freeze-drying provided the highest contents of iron, magnesium, sodium, and potassium. Regarding the antioxidant components, the freeze-dried powder showed the highest levels of total phenolic compounds, flavonoids, and vitamin C. Similarly, freeze-drying provided the best antioxidant capacities in terms of DPPH scavenging and the ferric reducing antioxidant power. Our study showed that freeze-drying ensured a better retention of essential nutrients and antioxidant components in the mushroom V. volvacea, while sun-drying led to greater losses of these compounds.
Decreased Follistatin Levels as a Risk of Acute Sarcopenia Marker in Elderly
Authors: Aryana I Gusti Putu Suka , Winangun I Made Arya
Published: November 2023

Background: Acute sarcopenia is an acute muscle loss that has been associated to the frailty and vulnerability of the elderly. Follistatin has been known as a significant marker for sarcopenia, however, studies of follistatin in humans have shown varying results and there have been no studies to date regarding the relationship between follistatin and acute sarcopenia. The aim of this study was to determine changes in follistatin levels as a risk of acute sarcopenia in elderly.Materials and methods: This study was a prospective observational study involving hospitalized elderly. The follistatin level was examined with enzyme-linked immunosorbent assay (ELISA). Meanwhile the determination of acute sarcopenia was done through the measurement of changes in hand grip strength and calf circumference parameters. The data obtained was descriptively analyzed, followed by bivariate and multivariate analysis. A p<0.05 was considered significant.Results: There were 66 subjects in this study. A total of 10 subjects (15.2%) had acute sarcopenia on the 7th day of hospitalization. The cut-off point of decreased follistatin levels was 4.870 with a sensitivity of 82.1% and a specificity of 60%. There was an association between decreased follistatin levels and acute sarcopenia (p=0.01; RR: 6.90; 95% CI: 1.638-29.069). Multivariate analysis results showed that decreased follistatin levels was a significant factor that might influence the occurrence of acute sarcopenia.Conclusion: Since this study showed that decreased follistatin levels might be a risk of acute sarcopenia in the elderly, thus it could be used as a marker of acute sarcopenia, which should be further investigated.Keywords: decreased follistatin levels, acute sarcopenia, elderly
Mesenchymal Stem Cell in 3D Culture: Diminishing Cell Senescence in Cryopreservation and Long-term Expansion
Authors: Jundan Sheila Fawziyya , Amalia Riezki , Sartika Cynthia Retna
Published: November 2023

Mesenchymal stem cells (MSCs) are widely recognized in cell treatment due to their capacity to secrete trophic factors, differentiate multipotent, and self-renew. Although there is growing evidence that MSCs have therapeutic benefits in various clinical settings, these cells eventually lose their ability to regenerate as they age, which increases cellular dysfunction. Several factors may affect MSCs aging, such as culture dimensions, cryopreservation process, and long-term expansion. Traditional two-dimensional (2D) culture conditions lack the complexities required to recreate MSCs in their natural environment. Meanwhile, three-dimensional (3D) culture mimics the niche, dynamic, and specialized microenvironments of the cells in vivo. The most used storage technique for MSCs, cryopreservation, requires a very low temperature reduction, which stresses cells and can cause the release of pro-inflammatory cytokines. For the utilization of MSCs in therapeutic applications, an in vitro expansion technique is required. Repeated expansion may reduce proliferative capacity, disrupts cellular shape, and impairs the somatic cell function of MSCs. Various processes and techniques may influence MSCs leading to cell aging. One of the culture methods, 3D culture, is shown to reduce the factors that will compromise the therapeutic effects of MSCs, especially cell senescence. The effect of culture dimensions, cryopreservation, and long-term expansion on cell senescence will be discussed in this review article.Keywords: cell aging, mesenchymal stem cell, 3D culture, cell senescence, cryopreservation, long-term expansion
Development of Wheatgrass (Triticum aestivum) Extract Loaded Solid
Lipid Nanoparticles using Central Composite Design and its
Characterization- Its In-vitro Anti-cancer Activity
Authors: Minocha Neha , Pandey Parijat , Sharma Nidhi , Saini Sangita
Published: November 2023

Background:

The prevalence of cancer is around the world and is identified as a multifactorial
ailment. One of the most common causes of cancer in the world is oxidative stress, and
this can be overcome by taking herbal plant wheatgrass in any form. As colloidal carriers with
particle sizes of 50-1,000nm, Solid Lipid Nanoparticles (SLNs) combine the benefits of liposomes,
emulsions, and other colloidal systems to deliver drugs at their targets.

Objective:

Aim and objective of the present work is to formulate wheatgrass extract loaded solid
lipid nanoparticles using Central Composite design and to investigate the effect of formulation
variables. Using hot homoginization method, the present work aimed to formulate wheatgrass
loaded chitosan solid lipid nanoparticles using central composite design and to evaluate the extract
potential to treat breast cancer on MCF-7 cell line.

Methods:

This study investigated the effect of three formulation variables on particle size, namely
the sodium alginate concentration, the calcium carbonate concentration, and the homogination
time. Extraction of wheatgrass was done in soxhlet extractor, using methanolic extract. The hot
homogenization technique was used to prepare Triticum aestivum extract loaded solid lipid nanoparticles
(SLNs).

Result:

For CCD, all formulations were analyzed for particle size, which ranged from 362.5 to
933.8 nm, and for polydispersity index, which ranged from 0.137 to 5.799. Batch code SLN-6
was found to be finest suitable because of maximum loading capacity of 67.76 ±0.17 % (w/w),
maximum entrapment efficiency of 65.81 ± 0.11 % (w/w) and minimum particle size of 362.5nm
by using sodium alginate as surface stabilizer at homogenization time ~ 5 min and having maximum
percentage yield of 43.66%.

Conclusion:

During characterization studies and MCF-6 cell line studies, it was found that batch
code SLN-6 was found to be finest suitable and wheatgrass has anti-oxidant potential, and potent
against breast cancer.
A Review on Nanostructured Lipid Carriers as Promising Drug Delivery
Vehicle to Target Various Cancers via Oral Route: A Step towards
“Chemotherapy at Home”
Authors: Quadir Sheikh Shahnawaz , Joshi Garima , Saharan Vinod , Mangesh Harish , Choudhary Deepak , Yadav Khushwant , Jain Chandra Prakash , Chauhan Lalit Singh
Published: November 2023

Oral drug administration is largely preferred owing to enhanced patient compliance, convenience of self-intake of dose, non-invasiveness, and low manufacturing cost. Cancer is a condition that starts with aberrant cell division at an uncontrolled rate. The clinical effectiveness of many anticancer drugs is limited by their physicochemical characteristics and physiological circumstances in the GI tract. Nanostructured lipid carriers have the potential to enhance the bio-availability of anticancer drugs by entrapping them. The NLCs, by virtue of their nanosize and their biocompatibility, can bypass the first-pass metabolism and be taken up by M cells of Peyer’s patches to deliver the drug to the deeper tumours. The proposed review highlights the potential of NLCs in oral drug delivery for the management of various cancers. It discusses various strategies, method of preparation, mechanism of uptake, and their applications in the treatment of cancer via oral delivery. Further, it explains the recent advances and future perspectives.
Transphobic Truth Markets: Comparing Trans-hostile Discourses in British Trans-exclusionary Radical Feminist and US Right-wing Movements
Authors: Dickey Briar
Published: November 2023

British “Trans-Exclusionary Radical Feminist” (TERF) discourse has often been contextualised in fringe radical feminist thought, but its similarities to and alliances with right-wing trans-exclusionary movements in the US are notable (McClean, 2020). To understand the place of TERF discourse in an international wave of trans-hostility, it is necessary to understand how it converges with and differs from explicitly conservative counterparts. I place TERF discourse in comparison to trans-exclusionary discourses of the American Right (AR) using a Critical Frame Analysis, investigating the extent of shared themes and the role of ontological discourses across cases. I find that TERF and AR discourses converge heavily on frames and have a shared ontology, but draw on different repertoires to bolster their claims. Combining Harsin’s (2014) truth markets and Smith’s (1995) ideological code theory, I show how an ideological-code-like structure demonises and ontologically delegitimises trans people, demonstrating how reactionary frames can be granted cross-ideological appeal.
Parental Attitudes on Social Media Monitoring for Youth: Cross-Sectional Survey Study
Authors: Cohen Alyssa , Bendelow Anne , Smith Tracie , Cicchetti Colleen , Davis Matthew M , Heffernan Marie
Published: November 2023

Background

Online environments dominate the daily lives of American youth and pose evolving challenges to their health and well-being. Recent national poll data indicate that social media overuse, internet safety, and online bullying are among parents’ top child health concerns, particularly during the COVID-19 pandemic. While parents are uniquely positioned to help youth navigate social media, their attitudes on monitoring media use may be impacted by a myriad of personal and family factors.

Objective

This study aimed to examine factors associated with parental attitudes about monitoring social media use among youth.

Methods

Data were analyzed from the Voices of Child Health in Chicago Parent Panel Survey, administered to parents over the web and by telephone. Parents with at least 1 child aged ≥11 years responded to questions about bullying and social media monitoring from May to July 2020. The primary outcome was their response to the following question: “Do you think parents should monitor their children’s use of social media platforms such as Facebook, Twitter, and Instagram?” Bivariate analyses and multivariable logistic regression were used to examine parental agreement with frequent social media monitoring and concerns about bullying, adjusted for sociodemographic characteristics. Analyses were weighted to represent the parent population of Chicago.

Results

Among 1613 survey respondents, the analyzed sample included 808 parents with at least 1 child aged ≥11 years. Overall, 62.9% (n=566) of parents agreed with frequent parental monitoring of their children’s social media use. Compared with parents aged ≤35 years, parents who were >35 years old were significantly less likely to agree with frequent social media monitoring (adjusted odds ratio [aOR] 0.45, 95% CI 0.25-0.81). Parents expressing a high level of concern regarding the effects of bullying were more likely to agree with frequent monitoring of youth social media (aOR 2.15, 95% CI 1.24-3.73).

Conclusions

Parents’ personal characteristics and concerns about bullying may influence their attitudes toward monitoring social media use among youth. Given the potential impact of these attitudes on parental monitoring behaviors and the subsequent health impact on youth, pediatricians should consider these factors when counseling about bullying and social media. Child health professionals can support families in developing a safe media use plan that fits family circumstances.
Based on the Integration of “Internet + Ideology and Politics”, the Practice of Online and Offline Mixed Teaching Mode of Modern Medical Courses in Traditional Chinese Medicine Majors
Authors: Junjie Zhao , Jiajing Zhou , Junwen Jiang , Juanjuan Huang , Chen Rui
Published: November 2023

The purpose of this paper is to explore how to implement the online and offline mixed teaching mode in the modern medical courses of TCM specialty under the guidance of the concept of “Internet + ideological and political integration”, and to explore its practical experience and remarkable results. With the power of today’s Internet technology, we will organically integrate ideological and political education into the modern medicine course of traditional Chinese medicine, so as to effectively promote the overall cultivation of students’ comprehensive quality, and further enhance the attraction of the course and educational benefits.
On Reconstruction of Teacher Professional Identity in Curriculum Reform for Vocational Education
Authors: Yang Zhaohui , Zhou Haixia
Published: November 2023

Vocational education curriculum is being reformed nationwide less than compulsory education. It sources from demonstrating college construction in higher vocational education, and imports design-oriented curriculum idea from German. To teachers, it is necessary to reconstruct their rights to utterance.
Traffic Sign Detection and Recognition System for Autonomous Vehicle
Authors: Jadoun Pratush
Published: November 2023

Abstract: Traffic Sign Recognition and detection system is specifically useful for drivers and driver-less cars. By identifying traffic signs accurately and effectively it improves the driving safety of autonomous cars. This research paper presents a comprehensive approach for the development of a traffic sign detection system using Convolution Neural Network, TensorFlow and OpenCV to classify the traffic signs in real-time effectively. TensorFlow and OpenCV play an important role in shaping effective traffic detection and recognition system. We have explained the process of data collection, preparation, model architecture and the integration of TensorFlow for training and interference. OpenCV for image processing and real time feed processing, ensuring seamless implementation on various hardware platform. The model uses German Traffic Sign Recognition dataset. The results show that the proposed system achieves high accuracy in detecting and recognizing traffic sign making it a valuable system for both autonomous vehicles and human drivers
Intuitive Perception - Speech Recognition using Machine Learning
Authors: K Mr. Kumar , Hegde Sanket G , G Shashikanth N , Korabu Vishal N , Charan Vummaneni
Published: November 2023

Abstract: Machine Learning is widely used to detect the movement of lips. It has been observed that the data generated through visual stir of mouth and corresponding audio are largely identified. This fact has been exploited for lip reading and for perfecting speech recognition. We propose a system that uses a CNN( Convolutional Neural Network) which is trained and used to descry the movement of lips and prognosticate the words being spoken. This trained CNN will be suitable to descry the words that are spoken within the videotape and display it in a textbook format. The CNN may also calculate on fresh information handed by the environment, knowledge of the language, and any residual hail. We hope to learn whether the application of machine literacy, more specifically the DNN( Deep Neural Network), could also be an applicable seeker for working the problem of lip reading. The main end of our design is to directly honor the expressions being spoken through automated lip reading
Advancements in Grain Adulteration Detection and Quality Assessment - A Survey
Authors: N Mr. Roopesh Kumar B , P Rakshitha , Shankari S Sai , N Vandana , Jhansi Y
Published: November 2023

Abstract: Food security and public health are severely compromised by food adulteration and quality deterioration, which have become pressing concerns. Unfavourable food quality is caused by a multitude of factors, including but not limited to the widespread adulteration of food. Food quality is heavily influenced by environmental variables, such as poor storage conditions, pest infestations, and contaminant exposure. Furthermore, food products may be exposed to adverse circumstances due to the complexities of transportation and distribution, which can result in microbial spoilage and a loss of nutritive value. Consumers are thereby subjected to a decreased level of nutritional quality from their diet in addition to health hazards. In the context of food grains, such as rice and wheat, the challenges are particularly noteworthy. As these grains form the essence of sustenance in regions like India, ensuring their quality is paramount. Grain quality evaluation has traditionally been done by hand using labour-intensive, human error-prone procedures. However, the prospect of automation and computer vision gives a glimmer of optimism in today's technologically advanced society. Systemic research and developments concerning the evaluation of grain quality have demonstrated that image processing techniques may be employed to automate the procedure. Such advancements give rise to the potential for more accurate, efficient, and scalable grain quality assessment.
The Behavioral Ecology of Resource Consumption: Why “Being Green” Is So Hard
Authors: Low Bobbi S.
Published: November 2023

The life history and behavior of humans, like those of other species, are shaped by natural selection. Some life history traits that heighten our resource consumption arise from an unusual combination of high intelligence and extreme sociality; as humans evolved, we have become ever smarter and more efficient about obtaining resources for ourselves. We humans are doing what other species do, extracting resources from the environment to survive and reproduce—but we have become so good at it that we are having an ever-increasing impact on populations of other species. The reactions of other species depend in part on their life history, shaped by their evolutionary past: have they repeatedly confronted extremes? Changes? Or, if they have had a long history of relatively little change in important environmental variables, how can they cope? Further, their life histories and ecologies are strong determinants of the most efficient human extraction techniques. Understanding life histories, both of other species and of our own, is important for a sustainable future; in some important ways, our evolutionary past constrains our ecological future. Here I present an overview of what is known.
Pengaruh Lingkungan Kerja dan Motivasi Kerja Terhadap Kinerja Tenaga Kependidikan Non-PNS Fakultas Teknik Universitas Mulawarman
Authors: Cahyani Annisha , Fathimahhayati Lina Dianati , Pawitra Theresia Amelia
Published: November 2023

Tenaga kependidikan Fakultas Teknik Universitas Mulawarman terbagi menjadi golongan PNS dan non-PNS tetapi penilaian kinerja serta penampungan aspirasi karyawan hanya dilakukan terhadap karyawan berstatus PNS. Kebutuhan dan harapan dalam setiap individu yang berbeda menyebabkan kualitas dari kinerja karyawan terganggu. Penelitian ini bertujuan untuk mengetahui pengaruh lingkungan dan motivasi kerja terhadap kinerja karyawan secara parsial dan simultan. Teknik Analisis yang digunakan regresi linier berganda dengan populasi sebanyak 32 orang karyawan tenaga kependidikan non-PNS. Hasil penelitian menunjukkan bahwa kondisi lingkungan kerja cukup baik dengan nilai kategorisasi sedang sebesar 37,5%, motivasi kerja cukup baik dengan nilai kategorisasi sedang sebesar 68,8%, kondisi kinerja karyawan cukup baik dengan nilai kategorisasi sedang sebesar 84,4%, lingkungan kerja dan motivasi kerja tidak berpengaruh terhadap kinerja karyawan dengan hasil uji koefisien determinasi menunjukkan pengaruh sebesar 12,6% terhadap kinerja karyawan. Rekomendasi yang diberikan yaitu diadakannya family gathering, penilain kinerja, evaluasi kinerja, pemberian penghargaan, dan penyediaan alat tulis kantor secara berkala.
Implementasi Metode Six Sigma untuk Mengurangi Defect pada Proses Produksi Kemasan Kopi Instan Butiran Coklat di PT. XYZ
Authors: Suwandi Arief , Rasjidin Roesfianjah , Amperajaya M. Derajat , Cholik Abdul
Published: November 2023

PT. XYZ memproduksi berbagai jenis kopi  dimana  produk kopi instan butiran coklat merupakan produk yang paling diminati baik lokal maupun ekspor. Terdapat banyak variasi kemasan dalam produksi butiran coklat yang ditambahkan ke kopi instan dan dengan menggunakan Key Performance Indicators (KPI), ditentukan bahwa penggunaan bahan pengemas produk Chocogranule menghasilkan tingkat waste atau error yang tinggi sebesar 1,44% (nilai indikatif 0,7%).  Penelitian bertujuan mengatasi masalah dengan memperbaiki proses produksi sehingga mengurangi limbah kemasan butiran coklat. Perusahaan dapat mengetahui dengan jelas kualitas produk yang diproduksi dan posisi kualitas produk di pasar. Penerapan metode Six Sigma dapat meningkatkan kinerja mesin dan volume penjualan dengan mengurangi jumlah produk cacat, dan penggunaan 5W + 2H menghasilkan faktor penyebab cacat pada produk butiran coklat.
Analisis Data Mining Pembelian dengan Association Rule Market Basket Analysis menggunakan algoritma FP-Growth
Authors: Dio Rafi , Hidayati Juliza , Arifin Riski , Putera Dimas Akmarul , Dermawan Aulia Agung
Published: November 2023

Pertumbuhan ekonomi di Indonesia menunjukkan kenaikkan dari tahun ke tahun. Salah satu bentuk dari peningkatan pertumbuhan ekonomi di Indonesia adalah dengan meningkatnya daya beli masyarakat. Kenaikan daya beli masyarakat berbanding lurus dengan meningkatnya kehadiran retail di Indonesia. Menghadapi persaingan yang dilakukan dari setiap retail berlomba-lomba untuk melakukan penjualan barang yang sering dibeli oleh masyarakat. Untuk mengetahui data historis ada retail dilakukan dengan AR-MBA untuk memodelkan hubungan produk yang dibeli secara bersamaan. Sehingga tujuan penelitian ini yaitu melihat pembelian antar produk pada suatu retail dengan AR-MBA menggunakan FP-Growth. Penelitian ini menggunakan 450 data dari hasil transaksi pada suatu retail. Hasil penelitian yang didapatkan adalah terdapat 8 associatioan rule terbentuk dengan nilai lift rasio > 1 serta tingkat kepercayaan minimal 30% dari setiap hubungan terbentuk. Berdasarkan 8 rule selanjutnya dilakukan perancangan layout usulan untuk meningkatkan efiseiensi pelanggan saat berbelanja.
Analisis Penerapan Manajemen Risiko Pada Kontrak Penyediaan Jasa Pengangkutan Oil Country Tubular Goods Menggunakan Metode House of Risk (HOR)
Authors: Lusiani Mirna , Amara Tasya
Published: November 2023

Pada kegiatan di bidang hulu industri minyak dan gas bumi, tentunya memerlukan barang atau jasa untuk mendukung kegiatan perusahaan. Dalam pelaksanaan kontrak dengan penyedia dapat memungkinkan terjadinya risiko yang dapat merugikan berbagai pihak yang terlibat. Tujuan dari penelitian ini adalah untuk mengidentifikasi kejadian risiko dan penyebab risiko pada kontrak jasa pengangkutan material Oil Country Tubular Goods dengan metode House of Risk. Pada penelitian ini, terdapat 20 kejadian risiko dan 17 penyebab risko. Berdasarkan hasil diagram pareto, diketahui tiga risk agent dengan ranking tertinggi terdapat pada kelalaian pekerja, keterlambatan memberikan respon, dan kurangnya pembinaan dan pengawasan rutin. Dari ketiga risk agent tersebut, terdapat empat rekomendasi aksi mitigasi yang diterapkan untuk mengurangi penyebab risiko dengan nilai ETD tertinggi yaitu melaksanakan kegiatan kick-off meeting dan safety meeting, memberikan pelatihan kepada personel dan subkontraktornya, melakukan pengelolaan aspek HSE untuk subkontraktor yang meliputi seleksi, monitoring, dan evaluasi, dan membuat tools sistem informasi selama pelaksanaan kontrak.