bluuebunny/crossref_metadata_2025 huggingface dataset:
Polscy mistrzowie teatru w Chinach
Authors: Duda Artur
Published: January 2020

Celem artykułu jest prezentacja wybranych aspektów współpracy teatralnej pomiędzy Polską a Chinami, w szczególności zaś recepcja w Kraju Środka postaci takich jak Jerzy Grotowski i Krystian Lupa.
Mistrzynie: kobiety w Uniwersytecie Mikołaja Kopernika w Toruniu. Przypadek Zofii Abramowiczówny
Authors: Bibik Barbara , Kola Adam F.
Published: January 2020

Artykuł składa się z trzech dopełniających się części i dotyczy herstorii jednej z polskich uczelni – Uniwersytetu Mikołaja Kopernika w Toruniu. Punktem wyjścia jest przygotowywana książka pt. Niewidzia(l)ne. Kobiety i historia Uniwersytetu Mikołaja Kopernika w Toruniu pod redakcją Aleksandry Derry, Anny Marii Koli oraz Wojciecha Piaska (planowana do wydania na koniec 2019, poprzedzona zaś warsztatami, seminariami oraz badaniami archiwalnymi). Część pierwsza tekstu szkicuje ogólne ramy projektu, druga – skupia uwagę na jednym szczególnym przypadku – Zofii Abramowiczówny, trzecia zaś część odnosi się do tematu przewodniego całości – kwestii mistrzostwa.
Efecto de la censura informativa sobre la potencia de algunas pruebas tipo Log-Rank.
Authors: Brun González L. P. , Salazar Uribe J. C.
Published: January 2020

El análisis de supervivencia consiste en un conjunto de técnicas para analizar el tiempo de seguimiento hasta la ocurrencia de un evento de interés, también denominado tiempo de vida, el cual se observa completa o parcialmente. En la práctica, un problema frecuente consiste en comparar las experiencias de supervivencia de al menos dos grupos bajo estudio. La estrategia de análisis más común consiste en usar pruebas Log-Rank, pero estas no distinguen si el mecanismo de censura es informativo o no. En este trabajo se evaluó, bajo diferentes escenarios de simulación, la potencia estimada de algunas pruebas Log-Rank cuando los datos presentan censura informativa. Se encontró evidencia de un mejor desempeño de la prueba de Wilcoxon.
Estudio de blindaje magnético en materiales conductores en función de la frecuencia.
Authors: Torres Velásquez J. A. , Viáfara Avila R. R. , Chacón Cardona C. A.
Published: January 2020

Se describe el efecto de un campo magnético uniforme en materiales conductores, y cómo estos apantallan el campo que los atraviesa. Con el fin de crear dicho campo,se energiza una bobina que encierra el material apantallador y la bobina sensor de campo magnético, mediante una señal sinusoidal producida por un generador de señales con una tensión de 10 [Vp]. La medida del campo magnético se realiza de manera indirecta ubicando una bobina como sensor en el centro de una bobina de diámetro mayor, realizando la medida de tensión en el sensor, de tal manera que al colocar un material apantallador que encierre la bobina se reduzca el campo magnético en su interior y, por ende, la tensión inducida en la bobina. Los materiales apantalladores que se emplearon fueron: acero, aluminio, hierro y cobre, la eficiencia de estos materiales fue estudiada en un rango de frecuencias de 60-100.000 Hz, obteniendo como resultado que el material más eficiente desde 60- 12.000 Hz es el hierro, y para 32.000-100.000 es el cobre.
BIM no ensino de tecnologia da construção
Authors: Leal Bianca Marques Figueiredo
Published: January 2020

A indústria da construção civil brasileira passa por uma fase de transição do modelo tradicional de projeto em Computer Aided Design (CAD) para o projeto mediado pela Modelagem da Informação da Construção (Building Information Modeling - BIM). Com isso, há um encadeamento natural de adequação dos profissionais à nova metodologia de trabalho e, consequentemente, surge a necessidade de capacitá-los. Por isso, cursos de Arquitetura e Urbanismo do Brasil estão alterando suas grades curriculares para implementar o ensino de BIM. Contudo, não tem sido discutida as alternativas de emprego do BIM na exposição dos conteúdos próprios à formação em Tecnologia da Construção. Dessa forma, o presente artigo possui o objetivo de apresentar possibilidades de uso do BIM no ensino de tecnologia da construção em curso de graduação de Arquitetura e Urbanismo a partir de um estudo de caso. Esse estudo apresenta resultados parciais de uma pesquisa de mestrado e utiliza como procedimentos metodológicos a pesquisa bibliográfica, documental e estudo de caso. Os resultados apontaram um grande potencial de utilização do BIM no ensino de tecnologia da construção, bem como em outras áreas do curso de arquitetura e urbanismo sem necessidade de alteração curricular. Por fim, esse estudo evidencia as mudanças que podem ocorrer na sala de aula se o docente se apropriar das ferramentas digitais existentes e se a instituição e a coordenação apoiarem essa proposta.
GRADUASI MANDIRI: BENTUK KEBERDAYAAN PENERIMA MANFAAT (KPM) PROGRAM KELUARGA HARAPAN (PKH) DI KABUPATEN PATI
Authors: Khoiriyah Nur , Kunarti Kunarti
Published: January 2020

Independent graduation, is a phenomenon of resignation from PKH program membership. This is different from some other social ministry programs. Programs that encourage the empowerment of beneficiary communities. Based on this uniqueness, this study specifically examines how the condition of PKH participants before and after graduation, as well as looking for forms of empowerment that are owned by PKH Graduasi Mandiri participants. Field findings indicate the empowerment process carried out by PKH facilitators through regular monthly meetings. Assistance is filled with the delivery of empowerment material. Materially, not much amount of assistance was received, but the assistance was carried out continuously. The form of KPM PKH empowerment after independent graduation can be seen through five indicators, including freedom of mobility, ability to buy small commodities, being involved in household decision making, having relative freedom from family domination, and having economic security and contribution to the family.
Attitude, Smoking Behavior, and Physical Activities Toward Diabetes Mellitus–Pulmonary Tuberculosis
Authors: Afidah Retno Lian
Published: January 2020

Background: Every year an average of 9 million people suffer from Tuberculosis and about 2 million people die every year in the world. The Behavior Area is divided into attitudes and actions. Purpose: The purpose of this study was to analyze the relationship between attitude, smoking behavior, physical activity and the incidence of Diabetes Mellitus–pulmonary Tuberculosis. Method: This study was an observational analytic study using a case control matching design. The research sample is 30 case samples and 30 control samples. Results: From the results of the Chi Square analysis, it is known that there is a significant relationship that is the attitude towards pulmonary Tuberculosis disease and physical activity towards pulmonary Tuberculosis (p<0.05) and there is no significant relationship (p>0.05) between smoking behavior towards Pulmonary of Diabetes Mellitus–pulmonary Tuberculosis. Odds Ratio of this study is the attitude towards pulmonary Tuberculosis disease of 3.455 and physical activity of 9.036. Conclusion: the attitude of patients with Diabetus Mellitus towards Pulmonary Tuberculosis and physical activity of patients with Diabetus Mellitus risked the incidence of Pulmonary Tuberculosis.
Gambaran Perilaku Pencarian Pengobatan Pada Mahasiswa Fakultas Kesehatan Masyarakat Universitas Airlangga
Authors: Febriani Wahyu Mila
Published: January 2020

Latar belakang: Perilaku pencarian pengobatan merupakan segala tindakan atau upaya yang dilakukan oleh individu dengan tujuan menemukan pengobatan yang tepat saat merasa/menganggap dirinya sedang memiliki gangguan kesehatan. Mahasiswa sebagai individu yang sudah dianggap mampu bertanggung jawab atas diri sendiri memiliki kuasa atas dirinya untuk menentukan perilakunya, termasuk dalam upaya pencarian pengobatan. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran perilaku pencarian pengobatan pada mahasiswa Fakultas Kesehatan Masyarakat Universitas Airlangga. Method: Jenis penelitian yang digunakan adalah observasional analitik dengan studi korelasi chi-square dan rancang bangun cross sectional. Sampel penelitian berjumlah 96 mahasiswa yang diambil dari total populasi sebesar 2462 mahasiswa FKM UNAIR dan dipilih secara acak menggunakan teknik sampel acak sederhana. Variabel pada penelitian ini terdiri dari perilaku pencarian pengobatan sebagai variabel terikat, sedangkan persepsi kerentanan, persepsi keseriusan, persepsi manfaat dan persepsi hambatan sebagai variabel bebas. Hasil: Hasil penelitian menunjukkan bahwa jumlah mahasiswa Fakultas Kesehatan Masyarakat Universitas Airlangga yang melakukan tindakan pengobatan saat pertama kali merasakan gejala penyakit sebesar 37,5%. Berdasarkan hasil uji statistik dapat diketahui jika variabel perceived seriousness (P value = 0,176) dan perceived benefit (P value = 0,446). Sedangkan variabel perceived susceptibility (P value = 0,003) dan perceived barriers (P value = 0,005). Kesimpulan: Terdapat hubungan antara persepsi kerentanan dan hambatan yang dirasakan  dengan timbulnya perilaku pencarian pengobatan pada mahasiswa Fakultas Kesehatan Masyarakat Universitas Airlangga, Surabaya.
Hubungan Tindakan Pencegahan Ibu dengan Kejadian Diare pada Balita
Authors: Hendrastuti Carita Bidari
Published: January 2020

Latar Belakang: Setiap tahun 6 juta anak kehilangan nyawa yang disebabkan oleh kasus diare. Sebagian kematian tersebut terjadi di negara berkembang. Data dari Dinas Kesehatan Kota Surabaya menyebutkan bahwa jumlah kasus diare sebanyak  65.447 yang telah di tangani pada tahun 2015. Sedangkan tahun 2017 di Puskesmas Sidotopo yang membawahi kelurahan Ampel terjadi kasus diare sebanyak 611 kasus. Tujuan: Penelitian ini untuk mengetahui hubungan perilaku ibu dengan kejadian diare pada balita. Metode: Populasi adalah seluruh ibu balita di RT 2-3 RW XIII dan RT 1 RW XIV Kelurahan Ampel Kecamatan Semampir Kota Surabaya.  Jenis penelitian adalah kuantitatif dengan design cross sectional. Pengambilan sampel penelitian dalam penelitian ini adalah menggunakan metode Slovin dengan teknik simple random sampling.  Jumlah populasi sebanyak 55 ibu dengan besar sample 35 responden. Hasil: Dua variabel menunjukkan hasil yang signifikan. Ada hubungan yang signifikan antara penyimpanan air minum di tempat yang bersih dan tertutup dengan kejadian diare pada balita (p value = 0,021). Ada hubungan yang signifikan antara pemberian ASI Eksklusif dengan kejadian diare pada (p value= 0,048). Perilaku cuci tangan pakai tidak berhubungan dengan kasus diare pada balita di Kelurahan Ampel. Kesimpulan: Faktor yang berpengaruh terhadap kejadian diare di Kelurahan Ampel adalah penyimpanan air minum di tempat yang bersih dan tertutup serta pemberian ASI Eksklusif.
Changes in gender relations in advertisement show on formula milk in television
Authors: Mutahir Arizal
Published: January 2020

In addition to selling products, formula milk advertisements also displayed an overview of what, who, and how is the Indonesian children’s identity. The process of constructing a gender perspective of Indonesian children occurred through the representation of children in these advertisements. This paper sought to read advertisements on formula milk in connection to gender relations. The purpose of this paper was to find out how the identity and gender of Indonesian children represented in formula milk advertisement. The constructionist approach used in this paper. Roland Barthes’s semiotic method used to read the child’s description and the child’s gender relations represented in the ad. The data of this paper were 45 adverts of formula milk from eight different brands that aired on television throughout 2011. In the reading process, it revealed that the description of gender roles in formula milk advertisements was a new form of gender relations in Indonesia. In advertisements, there was a mother figure who is still concerned with domestic roles. However, the boundary between domestic space and public space had been fading. The appearance of men had undergone modifications. Fathers were displayed interacting with his children in a friendly manner. This change in appearance did not necessarily change gender stereotypes. Boys were still dominant. They showed as healthy and smart. It had implications for gender ideas that were embedded and expressed in the appearance of children. Boys showed preparing to stare at the future with all the advantages attached to them. Children who showed advertisements of formula milk are boys who look contemporary, creative and come from the middle class.
Angry, Hungry T-Cells: How Are T-Cell Responses Induced in Low Nutrient Conditions?
Authors: Nicoli Francesco
Published: January 2020

Upon activation, T-cells increase the uptake of glucose and glutamine to build the constituents of proliferating effectors. However, tumor and infected cells compete for the same nutrients. Several observations are consistently indicating that activated T-cells overcome this situation by engaging catabolic pathways. Here I discuss how these observations are reconciled with T-cells’ need of anabolic processes during activation.
Time-Dependent miRNA Profile in the Mouse Kidney during LPS Preconditioning
Authors: Tod Pál , Róka Beáta , Kaucsár Tamás , Szatmári Krisztina , Szénási Gábor , Hamar Péter
Published: January 2020

Background: Pre-treatment with lipopolysaccharide (LPS) protected the kidney against a later lethal ischemia. To reveal the mechanisms of renal cross-tolerance and septic acute kidney injury we investigated the effects of LPS on miRNA expression in the kidney. Methods: Male NMRI mice were injected with 40 and 10 mg/kg LPS ip. and sacrificed at 1.5 and 6 hours (early preconditioning, EP) and at 24 and 48 hours (late preconditioning, LP). The miRNA profile was established using miRCURY LNA™ microarray and confirmed with qPCR. Results: Plasma urea concentration peaked at 24 hours after LPS and decreased thereafter. Renal TNF-α and IL-6 mRNA were extremely elevated at all time-points. miRNome changes were mild at 1.5 hours, most miRNAs were altered at 6 and 24 hours and declined by 48 hours. Not all miRNAs could be assayed or validated by qPCR. In EP miR-762 was newly identified and validated and was the most elevated miRNA with both methods. In LP miR-21a-5p was the most influenced miRNA followed by miR-451a, miR-144-3p and miR-146a-5p. MiR-21a-3p increased significantly in both EP and LP. Conclusion: miR-762 might attenuate the LPS-induced immune response during EP and the miR-144/451 cluster is involved in LPS-induced renal preconditioning.
Komagata’s “paperscapes”
Authors: Huang Honglan
Published: January 2020

In picturebooks, the text, the image and the material book compete or cooperate with each other to convey and perform the narrative. The incorporation of material elements into the picturebook narrative at the same time extends reading beyond a purely cognitive activity: the reader enacts and interprets the narrative by interacting physically with the architectural space of the book. In Katsumi Komagata’s Blue to Blue, the paper steps forward to take up a significant narrative role rather than retreating as the decorative backdrop or mere material support for the visual and textual elements. Not only do the qualities of the paper like texture, transparency and luminosity evoke features of the landscapes and characters in the story, but the shapes of the paper and the die-cuts also create physical depth and form characters that spring into life at the turning, poking and caressing of the reader’s hands.
Ideology conveyed via the material(ity) of picturebooks
Authors: Yannicopoulou Angela
Published: January 2020

Picturebooks transmit messages through words and images and even through their format, but they transmit subtle subtext through their materiality. This paper examines how the material of the book-object is intentionally manipulated to contribute to an ideological significance of a picturebook as it complements and occasionally even contradicts the messages transmitted through words and pictures. This study reviews several picturebooks that use the materiality of the book as a moralising mechanism intended to expose the reader to the life lesson that as a member of society the responsibility for the environment and righting social injustices falls on all of us.
Materiality in Bruno Munari’s book objects
Authors: Campagnaro Marnie
Published: January 2020

This paper reviews the primacy of materiality in Bruno Munari’s work based on the case study of two of his picturebooks. Bruno Munari was one of 20th-century Italy’s most eclectic figures. Over the course of his lengthy career as an artist and designer, Munari explored the field of materiality in children’s books with exceedingly favourable results. His picturebooks set a precedent in the field of children’s literature, and they are highly valued even today. Children are fascinated by the opportunity to organise the experience of reading more freely thanks to innovative graphic and typographic mechanisms that fully exploit the editorial potential of materials such as paper, construction paper, and cardboard, but also transparent or semi-transparent sheets of acetate film, wood, plastic, sponge, and so on. In this paper, I describe the exclusive relationship that Munari developed over the years with the book as an object in all its various components (text and paratext). To do so, I discuss two of Munari’s significant editorial projects, the picturebook entitled Nella notte buia [In the Dark of the Night] (1956) and I Prelibri [Prebooks] (1980). I analyse the ways in which the Milanese artist succeeded in exploiting all the communicative, aesthetic and educational potential of these books’ material dimension.
Materiality in picturebooks
Authors: Veryeri Alaca Ilgım
Published: January 2020

Through this special issue, we seek to explore the educational, creative, and intimate qualities of materials and structures in picturebooks in emerging and existing book formats. From hornbooks to iPads, children’s reading experiences have been mediated via transforming book systems in ways serving to educate, to entertain, and to facilitate narrative. Material and sensory aspects of picturebooks also have the capacity to act as a third narrative system, operating besides words and images. These aspects may engage and challenge the child to comprehend a subject through the experiential handling of the picturebook, resulting in an embodied meaning-making process. Physical interactions may be explored further in printed as well as digital picturebooks with the rise of multimodal literacies supported by novel technologies that can cater for diverse needs. This special issue stems from a workshop entitled “The Material, Spatial and Sensory Encounters with the Picturebook Object” which took place at Koç University, İstanbul, in June 2017. It builds on the exchanges facilitated by the workshop, and aims to reflect on how book systems alter the way children perceive texts.
Analisis Perbandingan Kualitas Buku Teks Bahasa Arab Ta’lim Al-Lughoh Al-Arobiyah Dan Al-‘Ashri : Kajian Isi, Penyajian Dan Bahasa
Authors: Hikmah Khizanatul , Astuti Ruli
Published: January 2020

This study analyzed the comparison of the quality of Arabic textbooks Ta’im Al-Lughoh Al-Arobiyah and Al- Ashri based on the content review, presentation and language aspects aimed to describe and compare the quality of Ta'lim Al-Lughoh Al-Arobiyah and Al-'Ashri in terms of content, presentation and language. This research usedContent Analysis method. Respondents in this research are Arabic language teachers of SMA Al-Fattah Buduran and SMA Muhammadiyah 3 Tulangan. Data collection in this research using questionnaire filling technique, documentation and literature study.
The results of this study are (1.1) Arabic Text Book al-'Ashri class X for SMA / SMK / MA Muhammadiyah published by PT. DMU has complied with standard of content / material review, presentation, and language aspects based on BSNP. This is indicated by the average score on the content / content assessment aspect 85.03%, presentation aspect 78.05%, and the language aspect 90.62%, (1.2) Arabic Textbook Ta'lim al-Lughoh al-'Arobiyah class X for SMA / SMK / MA written by Dr. D. Hidayat with the publisher Pt. Toha Putra has fulfilled the standard aspects of content / material review, presentation, and language based on BSNP. This is indicated by the average score acquisition on content / content review aspect 95,64%, presentation aspect 81,82%, and language aspect 96,49%.
Peranan Faktor Demografik Dalam Hubungan Antara Motivasi, Gaya Pembelajaran, Disiplin Pembelajaran dan Pencapaian Akademik Pelajar
Authors: Chik Zamri , Abdullah Abdul Hakim , Muda Habsah , Istikomah Istikomah
Published: January 2020

Demographic factors are factors that determine the relationship between motivation, learning style and learning discipline on the academic achievement of Islamic education. Indeed, this study was carried out to determine the relationship between the motivation, learning style and learning discipline to the academic achievement of Islamic education. A total of 260 fourth graders become study samples. The study shows that male genitalia have a modest impression (moderator) that is significant in the relationship between motivation and academic achievement, but female females are not and the conclusion that females have a full moderation in this relationship. Both jantina (male and female) do not have a significant moderating impression in the relationship between motivation and learning discipline and the conclusion that jantina does not have a simple moderation effect in this relationship. Furthermore, the two jantinas (male and female) have a significant moderating impression in the relationship between learning styles and academic achievement and the conclusion is that Jantina has a partial mediation in this relationship. Whenever, female marriage is a significant moderator in the relationship between the discipline of learning and academic achievement, but male sex is not and the conclusion that the female has a full moderation in this relationship.
Implementasi Metode Group Investigation Terhadap Peningkatan Prestasi Belajar Sejarah Kebudayaan Islam Kelas IV Madrasah Ibtidaiyah
Authors: Wicaksono Bagus
Published: January 2020

The purpose of this study was to determine whether the implementation of the method of group investigation can improve the learning achievement of fourth grade students in semester 2 of the SKI subject in the subject of 'Mi' of the Prophet Muhammad SAW at MI . This research is a classroom action research (CAR) in which there are steps of planning, action, observation and reflection in each cycle. Data collection techniques using observation, interviews, questionnaires and documentation. The data obtained were calculated using descriptive percentage analysis techniques. The results of observations made by researchers showed an increase in student achievement. In the first cycle, the average grade of 69. Students who experienced mastery in learning are still 16 students or 50% while students who have not completed the learning process also have 16 students or 50%. In the second cycle after the improvement is made, the average grade of the class becomes 80.3. There are 24 students or 75% have been completed in learning students who have not completed the learning process there are 8 students or 25%. This shows an increase of 25%.
IMPACT RESILIENCE: ECOLOGICAL RECOVERY OF A CARBONATE FACTORY IN THE WAKE OF THE LATE DEVONIAN IMPACT EVENT
Authors: RENDALL BENJAMIN E. , TAPANILA LEIF
Published: January 2020

Conformable limestone deposits bracketing the Alamo breccia (Late Devonian, Nevada) provide a robust dataset for comparisons of depositional environments and marine communities before and after a significant meteor impact. Rank abundances of more than 3000 faunal identifications from 158 sampling localities cluster in three major faunal groups that are arranged in an onshore-offshore lithofacies gradient. Comparison of faunal clusters before and after the impact show little to no dissimilarity. The recovery of marine invertebrate communities following the Alamo impact event was geologically instantaneous. Broad geographic ranges of the fauna may have contributed to ecological resilience. From a geologic perspective, marine communities appear to rebound quickly and fully following meteor impacts, leaving impact-related extinctions as outliers that correspond only to the largest impacts.
The use of botulinum toxin for the treatment of patients with overactive bladder
Authors: Licow Agnieszka , Ciećwież Sylwester , Ptak Magdalena , Kotlęga Dariusz , Starczewski Andrzej , Brodowska Agnieszka
Published: January 2020

Overactive bladder affects 12–17% of the population, and mainly women, and its incidence increases with age. Diagnosis of this condition is based mainly on the patients’ complaints. These symptoms significantly affect the quality of life of millions of patients, involving considerable social, psychological, professional, physical and sexual problems. The wide incidence of this condition makes it necessary to find new medical substances in order to effectively eliminate the symptoms. Neurotoxins are a group of medical drugs that hold great promise for the future. Botulinum toxin is currently being used to treat symptoms related to overactive bladder. It can constitute an appropriate therapeutic option, in particular with regard to patients for whom the use of standard anti-cholinergic drugs is unsatisfactory or leads to severe side effects. Numerous research studies confirm that botulinum toxin can be efficiently used in the treatment of overactive bladder. The properties of this neurotoxin allow selective deactivation of overactive muscles. The use of botulinum toxin can be a method of treatment that significantly improves patient quality of life.
Localization of paresthesia in patients with carpal tunnel syndrome
Authors: Puchalski Piotr , Abramczyk Urszula , Dziubiński Dawid , Jedut Wojciech , Żyluk Andrzej
Published: January 2020

Introduction: Paresthesia (numbness, tingling, “pins and needles” sensation) and pain in the hand comprise a typical set of symptoms of carpal tunnel syndrome. Most authors consider a typical occurrence of these features within the palmar surface of digits I–IV, innervated by a compressed median nerve. Observations of patients by various authors show that some patients feel pares-thesia in all digits of the affected hand and within the forearm. The objective of this study was investigation of the distribution of paresthesia in patients diagnosed with carpal tunnel syndrome, and verification of the hypothesis that this occur-rence in areas beyond the innervation by the median nerve is an atypical manifestation of the syndrome.

Materials and methods: Questionnaires and notes filled out during baseline examination of 276 patients admitted to authors’ institution for carpal tunnel release over a period of 1 year were reviewed. The group consisted of 211 women (76%) and 65 men (24%) at a mean age of 59 years.

Results: Two hundred seventy-four patients (99%) reported feeling paresthesia within the involved extremity, and 2 did not, but complained of pain and reduced sensation. Most patients – 140 (51%) – felt paresthesia on the palmar surface of all 5 digits, including the little finger. Seventy-eight persons (28%) reported a “typical” distribution of paresthesia within digits I–IV and 31 (11%) in digits I–III. As many as 152 patients (55%) felt paresthesia in the little finger, most of them being cases with numbness and tingling present in all 5 digits. The feeling of paresthesia in the midhand, close to the involved digits was reported by 158 patients (57%).

Conclusion: We found that the distribution of symptoms in carpal tunnel syndrome does not closely match the anatomy of the median nerve and this presentation should no longer be considered atypical.
The role of microRNAs in angiogenesis
Authors: Bujak Joanna , Kopytko Patrycja , Lubecka Małgorzata , Sokołowska Katarzyna , Tarnowski Maciej
Published: January 2020

Angiogenesis is the process that leads to the formation of new blood vessels. Under physiological conditions it occurs, inter alia, during corpus luteum formation and in some stages of the menstrual cycle. However, angiogenesis plays an essential role in many pathological conditions, particularly cancer. New blood vessel formation provides cancer cells with oxygen and essential nutrients, which stimulates tumor growth and facilitates its metastasis. Increasing evidence indicates that angiogenesis is regulated by microRNAs (miRNAs), which are small non-coding RNA molecules of 19–25 nucleotides. The main function of miRNAs is post-transcriptional regulation of gene expression, which controls many key biological processes, including cell proliferation, differentiation and migration. Endothelial miRNAs, known as angiomiRs, are presumably involved in tumor development and angiogenesis through regulation of pro- and antiangiogenic factors. To date, the miRNAs that stimulate angiogenesis are: miR-9, miR-27a, miR-30d, miR0-130b, miR-139, miR-146a, miR-150, miR-155, miR-200c, miR-296 and miR-558. Conversely, miRNAs that inhibit angiogenesis are: miR-145, miR-519c, miR-22, miR-20a, miR-92, miR-7b, miR-221, miR-222, miR-328 and miR-101.
Professional competences in family nurse practitioners in North-Western Poland
Authors: Kęcka Katarzyna
Published: January 2020

Introduction: Professional nursing is increasingly often understood as accompanying and assisting people during health, disease and limited fitness. It is also shaping their self-care capabilities. The complexity of these tasks puts great responsibility on nurses, since they are those health care professionals who are in direct contact with patients’ families and communities. Nurses’ functions are exceptional because they involve the management and organization of holistic care in work with patients and their families (nursing and educational activities, cooperation with other members of a therapeutic team).

The purpose of this study was to analyze their level of knowledge concerning their tasks and professional competences in family nurse practitioners employed in primary health care centers.

Materials and methods: The research were carried out from February 2014 to the end of October 2015 in entities providing nursing services in primary health care in north-western Poland. For the analysis 643 questionnaire surveys were accepted.

Results: Family nurse practitioners in north-western Poland show a satisfactory level of knowledge in the field of professional competence. Nurses have especially high levels of knowledge concerning patients’ access to nursing services, information provided by primary care physicians as part of cooperation in the care of a patient, the nursing process method, and care of elderly and chronically ill individuals. The nurses had gaps in their knowledge of selected nursing services, such as bladder irrigation, transport, and rectal procedures. Alarmingly low levels of knowledge were observed with regard to professional competence in the care of patients with mental diseases.
Kinematic and Mechanical Analysis of the Ankle Rotating-Traction-Poking Manipulation
Authors: Chunyu Gao , Baojian Wang , Liguo Zhu , Gao Jinghua , Jianguo Li , Jian Li , Minshan Feng
Published: January 2020

Background: In China, the ankle rotating-traction-poking manipulation (RTPM) has been used to increase range of movement and reduce pain in patients with lateral ankle sprains. But no research so far has quantitatively analyzed the kinematic and mechanical data of RTPM therapy. Therefore, the purpose of the present study was to analyze the kinematics and mechanics of RTPM technique.
Methods: A total of 60 volunteers who had ankle sprains participated in the study. A single physiotherapist specializing in RTPM worked with each of the subjects. Motion capture technology, self-developed mechanical gloves, and a data synchronization device were used to acquire kinematic and mechanical data during the RTPM.
Results: The mean maximum force of the thumb, index finger, and middle finger during the rotating was 18.89 N, 10.26 N, and 9.51 N, respectively, that of the traction force was 18.61 N, 13.25 N, and 8.33 N, respectively, and that of the poking force was 26.5 N, 8.61 N, and 10.62 N, respectively. The average time of rotating for six circles was 11.36 s. The average linear velocity of rotating was 58.28 mm/s, and that of traction-poking was 23.81 mm/s. The average linear acceleration of rotating was 0.43 mm/s2, and that of traction-poking was 0.54 mm/s2. The average displacements of traction and poking were 36.94 mm and 22.44 mm, respectively. The average angle of traction and poking were 23.27° and 22.76°, respectively.
Conclusions: The RTPM can be repeatable for clinical application, and also has features of gentleness, rhythmicity, and continuity.
Herbal medicine use and its associated factors among pregnant women attending antenatal care at Wollega University Referral Hospital, West Ethiopia.
Authors: Labata Busha Gamachu , Wakjira Getu Bayisa , Dedefo Mohammed Gebre , Mekonen Ginenus Fekadu , Golja Eba Abdisa , Jaleta Dessalegn Dereje
Published: January 2020

Background: Herbal medications are plant-derived materials or products with therapeutic or other human health benefits, which contain either raw or processed ingredients from one or more plants. There are many different types of herbal medicine that spring from different cultures around the world. All these have the use of medicinal plants in common. Developing world general population relies on these traditional medicines for primary care. Besides, pregnant women use herbal medicines because of pregnancy related ailments and normal aliments. Therefore, the study aimed to assess prevalence and factors associated with herbal medicine use among pregnant women attending antenatal care at Wollega University Referral Hospital. Method: A facility based cross sectional study was conducted among pregnant women attending Wollega University Referral Hospital antenatal care from May to June 2018. Written informed consent was obtained from study participants prior to data collection. Univariate and Multivariate logistic regression analysis was used to determine factors associated with herbal medicine use. Association was significant when p-value is less than 0.05. Result: A total of 238 pregnant mothers were participated in the study. The respondents’ age ranges from 17 to 46 years. The prevalence of herbal medicine use among pregnant women attending antenatal care at Wollega University Referral Hospital was 66.40%. The use of herbal medicine during pregnancy was 3.885 times more likely among rural residents (AOR =3.885, 95% CI 1.121-13.47) than urban residents. Respondents who has monthly income between 1001 to 2000 Ethiopian Birr (AOR=2.585, 95% CI 1.125–5.940) were 2.585 times more likely to use Herbal medicine as compared to those who earn >3000 Ethiopian Birr. However, mothers of planned pregnancy (AOR=0.335, 95% CI 0.114-0.986) were less likely to use Herbal medicine as compared to those who had unplanned pregnancy. Conclusion: The prevalence of herbal medicine use among pregnant women attending antenatal care at Wollega University Referral hospital was 66.40%. Commonly used herbs were Garlic (24.37%) and ginger (18.07%). Rural residence and low income had significantly associated to herbal medicine use while planned pregnancy was inversely associated to herbal medicine use.
Complete protection for mice conferred by a DNA vaccine based on Japanese encephalitis virus P3 strain that is used to prepare the inactivated vaccine in China
Authors: Wang Ran , Yu Xiaozheng , Wang Yan , Zheng Xiaoyan
Published: January 2020

Background The incidence of Japanese encephalitis (JE) has been dramatically reduced in China after the coverage of the vaccine. It is believed that the live-attenuated Japanese encephalitis virus (JEV) vaccine SA14-14-2 has contributed a lot. Another vaccine that seems to have faded out of the public is an inactivated vaccine based on the JEV P3 strain, which is still considered to have certain modifiability, such as being transformed into a DNA vaccine to improve its immunogenicity. Methods In this study, the protective efficacy induced by a Japanese encephalitis DNA vaccine candidate pV-JP3ME encoding pre-membrane (prM) and envelope (E) proteins of P3 strain in BALB/c mice. The prM/E genes of the JEV P3 strain were subcloned into vector pVAX1 (pV) to construct pV-JP3ME. Results The plasmid DNA was immunized BALB/c mice, high titers of IgG antibody and neutralizing antibody (nAb) against JEV were detected. The key cytokines in splenocytes upon stimulation with JEV antigens were secreted. Finally, complete protective efficacy was generated after challenge with the JEV P3 strain in mice. Conclusions The DNA vaccine pV-JP3ME based on JEV P3 strain in this study can induce specific humoral immune and cytokine responses in mice, and provide complete protection for mice against JEV.
Metallothionein alone or in combination with Prussian blue attenuates acute thallium systemic toxicity in rats.
Authors: Anaya-Ramos Laura , Díaz-Ruíz Araceli , Ríos Camilo , Montes Sergio , Aguirre-Vidal Yoshajandith , García-Jiménez Sara , Baron-Flores Veronica , Monroy-Noyola Antonio
Published: January 2020

Background: Acute Thallium (Tl) toxicosis is still a health problem, worldwide. Oral administration of Prussian blue (PB) is the antidotal treatment of election. On the other hand, metallothionein (MT) is a low-molecular-weight protein, with high content of cysteines (25–30%). MT is able to chelate metals as an efficient endogenous mechanism of detoxification. It is also a potent antioxidant. Methods: In this study, we tested the ability of MT at two doses (100 and 600 µg/rat), administered alone or in combination with Prussian blue (PB) (50 mg/kg) to decrease thallium (Tl) toxicity. A sublethal dose of Tl (16mg/kg) was injected i.p. to male Wistar rats. Antidotes were administered twice-daily, starting 24h after Tl injection, for 4 days. Tl concentrations were analyzed in body organs and brain regions, 5 days after Tl injection. Results: Results showed a diminution (p<0.05) of Tl concentrations in all organs by effect of PB alone or in combination with MT-100 and MT-600, whereas MT-100 only decreased Tl concentrations in testis, spleen, lung and liver. Likewise, Tl in brain regions was also diminished (p<0.05) by effect of PB and both MT-100 alone or in combination in most of the regions analyzed (p<0.05). The greatest diminution of Tl was achieved when the antidotes were combined. Plasma markers of renal damage, increased after Tl administration. Both PB and MT, either alone or in combination, prevented the raise of renal markers of Tl Toxicity. Conclusions: Our findings demonstrate that the combined treatment of PB + MT is a good antidotal option against thallotoxicosis.
Bacterial Resistance and Antisseptic Effects on the Eye Surface of Donor Corneas
Authors: Ito Célia , Silva Carla , Carneiro Lilian Carla , Barbosa Mônica , Neto José , Messias Aline , Feitosa Ana , Santos Adailton , Queiróz Pedro , Monteiro janaina , Santos Andressa , Avila Marcos
Published: January 2020

BackgroundThe antiseptic solutions most used by Eye bank or in ophthalmologic surgeries are polyvinylpyrrolidone-iodine and gluconate of chlorhexidine. Objetives: The objective of this study was to evaluate the antiseptic effect in the reduction of ocular globe microbiota from corneal donors, as well as to analyze the susceptibility of the microbiota to gentamicin. MethodsThirty pairs of corneas received antiseptics, with Povidone-iodine in the right eye and gluconate of chlorhexidine in the left eye, and for each time of action (5, 10 and 15 minutes), totalling three groups, and using 10 pairs of eyeballs to each group. Swabs were collected from the ocular surface prior to application of the solutions, after and at the time of preservation of the corneal tissue. After identification of the microbiota, an antibiogram test with gentamicin was performed. ResultsRegarding the data obtained in the second group, after the use of antiseptics, there was a reduction of 40% in the total of gram positive bacteria and a reduction of 75.9% to gram negative bacteria, the results shows that in the second group, both antiseptics were more effective to Gram negative bacteria. The third group results show the residual effect of antiseptics and there was a reduction of 99.1% of all micro-organisms. To the antibiogram test, 88% of the microorganisms isolated, were sensitive to gentamicin. ConclusionWas observed that using the tested concentration to each antissepetic, there are no action differences to descontamination between the two products, there was not differences between the action time too. Key-words: eye bank, enucleation, povidone-iodine, gluconate of chlorhexidine, transplantation.
First report of Blastocystis infection in pigs from large-scale farms in Xinjiang, China
Authors: Wang Rongjun , Zhang Ying , Jiang Yuxi , Xing Jinming , Tao Dayong , Zhang Longxian , Qi Meng
Published: January 2020

Background: Blastocystis is a commonly identified intestinal protozoan in humans and various animals. Few studies are available regarding the genetic characterization of Blastocystis infections in pigs in China. Methods: In this study, 801 fecal samples were collected from seven large-scale pig farms in Xinjiang and tested by polymerase chain reaction. Results: The average infection rate of Blastocystis was 21.7% (174/801); the infection rates for pre-weaning piglets, post-weaning piglets, fattening pigs, and sows were 7.1%, 10.0%, 31.8%, and 41.9%, respectively (χ 2 = 104.89; P < 0.01). Blastocystis subtypes ST1 ( n = 7), ST3 ( n = 2), and ST5 ( n = 165) were identified using sequence analysis of the small-subunit ribosomal RNA gene, with subtype ST5 being predominant in each of the pig farms. All the age groups were positive for Blastocystis . ST3 and ST5 were identified in pre-weaning piglets, and ST1, ST3, and ST5 in post-weaning piglets. In contrast, only the ST5 subtype was observed in fattening pigs and sows. Genetic polymorphisms were observed at the intra-subtype level, including two variations for ST1 (ST1A, ST1B), and seven for ST5 (ST5A to ST5G), by sequence alignment analysis and phylogenetic analysis. Conclusions: A high prevalence of Blastocystis was detected in pigs in Xinjiang, China. The infection rate increased significantly with increasing age of the pigs. ST5 was the predominant Blastocystis subtype in all age groups. Subtypes ST1, ST3, and ST5 may emerge as zoonotic pathogens in some areas of China because of the large scale of the pork industry and close contact between pigs and humans. More studies are needed to elucidate the transmission and public health significance of Blastocystis in pigs in various areas. Key words: Blastocystis , SSU rRNA, genetic polymorphism, pig, Xinjiang
Molecular detection of tick-borne haemopathogens in shelter dogs and Rhipicephalus sanguineus (sensu lato) ticks from Peninsular Malaysia
Authors: Sipin Quincie , Kamal Farina Mustaffa , Watanabe Malaika , Rani Puteri Azaziah Megat Abdul , Md Nur Mahiza , Aziz Nor Azlina Abdul
Published: January 2020

Background Canine tick-borne haemopathogens (TBH) constitute a significant concern worldwide. The detection of these TBH is mainly achieved by microscopic evaluation, seroprevalence, and molecular detection. The present study was designed to investigate the molecular detection of Anaplasma platys ,Babesia gibsoni, Babesia vogeli, andEhrlichia canisin shelter dogs andRhipicephalus sanguineus ( sensu lato )ticks infesting them in Malaysia.Results A total of 220 blood samples and 140 ticks were collected from 10 animal shelters in Peninsular Malaysia. The presence of haemopathogens was detected using conventional PCR, sequenced, and identified at the species level. Of the 220 blood samples, 77 (35%) were positive with at least one of the four haemopathogens, of whichE. canispredominated (20%) followed by B. gibsoni andB. vogeliboth with detection of 7%, andA. platys(12%). In tick samples, 5 (3.57%) of the collected samples were positive with at least one of the three haemopathogens. Low detection ofE. canisand A. platys were present (n = 2; 1.43%) as well asB. vogeli﻿shows only 1 sample positive (0.71%) and no detection of B. gibsoni . For co-infection in dogs, single infection is common (24%), while co-infection with two haemopathogens (10%) was also observed. The occurrence of infection with three TBH was also observed in the sampled dogs (1%).ConclusionE. canisis the most common TBH affecting shelter dogs in Peninsular Malaysia. Co-infection is quite common and the most common co-infection present wasE. canisandA. platys. The study highlighted the first extensive molecular detection of TBH in dogs and R. sanguineus ( sensu lato ) ticks in Malaysia
Pregnancy outcome of patients with septic shock complicating pregnancy: a retrospective study
Authors: Li Manyu , Yin Jie
Published: January 2020

Background: To detect the maternal and neonatal outcomes of late pregnant patients complicated with sepsis shock.Methods: The medical records of all late pregnant patients (>=28 weeks) complicated with septic shock from January 2011 through November 2018 in Peking Union Medical College Hospital were retrospectively reviewed. Pertinent literature was identified by searching PubMed and EMBASE.Results: A total 9 patients with an average age of 26.11±6.9 years were included in this study. And the mean gestational age at diagnosis of septic shock was 33 weeks plus 1 day. 87.5% of patients accepted emergency delivery, in which cesarean section was the main delivery mode. 7 patients underwent emergency delivery (including 3 cases of fetal death) and 3 cases of live births (including 1 case of mild neonatal asphyxia). The total maternal mortality rate was 33.3%, and neonatal death rate was 55.6%. Only 1 patient continued pregnancy after disease recovery. 15 published case reports were reviewed. The reported maternal and perinatal death rates were 20% and 46.7% respectively. 2 patients could continue pregnancy after treatment. Group A streptococcus was considered as the main pathogenic bacteria.Conclusions: Late pregnancy complicated with septic shock was associated with high maternal and fetal mortality. Emergency delivery was advised in most of patients. And cesarean section was the main mode of delivery.