bluuebunny/crossref_metadata_2025 huggingface dataset:
Using interpersonal psychotherapy (IPT) to orientate well-being improvement toward freshmen in the digital era
Authors: Nguyễn Thị Tuyết Hạnh
Published: June 2023

It is undeniable that during the learning journey in colleges and universities, along with the intense pressure of academic tasks and family commitments, undergraduates can be exposed to exacerbation and diagnoses of mental health problems, which may lead to their failure in learning performance and world view perception [1, p2]. Hence, this study will conduct a survey of 141 students to find out what the most popular problem is for freshmen and apply one aspect of IPT to 10 students to examine its efficacy. From this point, the results found will offer an inducement for the forthcoming application and adjustment in orientation or academic programs at the tertiary level.
The Papermill Alarm: Patterns in PubMed
Authors: Day Adam
Published: June 2023

This post is about The Papermill Alarm: an API for detecting potential papermill-products.There’s a field of study called ‘stylometry’ where we look at the statistical properties of someone’s writing and use that to model their ‘style’. People write in idiosyncratic ways. So, for example, I often start sentences with ‘so, for example’ when I could more succinctly say ‘for example’. The stylistic properties of written work can therefore, potentially, give away the identity of the author....
How to unlock your paper and help the climate crisis
Authors:   OA.Works
Published: June 2023

At an event hosted by the United Nations library, we announced the Open Climate Campaign is using ShareYourPaper to help climate scientists unlock their papers and accelerate progress on climate change.
Papermills in peer-review
Authors: Day Adam
Published: June 2023

Dissecting a joke is a bit like dissecting a frog. No one needs to know what’s inside and the frog dies. — Jimmy CarrLast week, a paper I wrote on the subject of peer-review fraud was published in the journal Scientometrics (free link here, preprint here).It was an interesting project to work on. I found a lot of examples where one referee would write a report during peer-review and then another referee would write an identical report in some other peer-review of some other paper. (I wasn’t...
The definition of plagiarism
Authors: Day Adam
Published: June 2023

This is Ralph. How tall is Ralph?It seems simple, you could just hold a ruler up to the screen. But when you look at the ruler and use it to measure Ralph, are you actually measuring Ralph, or are you measuring the ruler and using that as a proxy? How accurate is your measurement? Are you including fur in the measurement? What if Ralph were to stand on his hind legs, like a mighty bear — how tall would he be then?This is a problem with measurement science. You can often only measure a proxy of...
A taxonomic search engine
Authors: Page Roderic
Published: June 2023

Tony Rees commented on my recent post Ten years and a million links. I’ve responded to some of his comments, but I think the bigger question deserves more space, hence this blog post. Tony’s comment Hi Rod, I like what you’re doing.
Dietas con diferentes relaciones Energía/Proteína para el engorde de codornices (Coturnix coturnix japónica) machos
Authors: Cantos Cruz Mayra V. , Avellaneda Cevallos Juan H. , Casanova-Ferrín Lola M. , Peña-Galeas Mayra M. , Morales-Intriago Fátima L. , Abril Vallejo Consuelo G. , Tapia-Moreno Edwin O.
Published: June 2023

Para estudiar el efecto energía/proteína en la respuesta productiva y rendimiento a la canal de la codorniz japonesa (Coturnix coturnix japónica), se utilizaron 288 codornices machos de 21 días de edad alojados en jaulas con 12 animales cada uno, alimentados con niveles crecientes de energía/proteína generando seis dietas con dos niveles de energía (3000 y 3200 kcal EM kg-1) y tres de proteína (21, 23 y 25%) en tres periodos de tiempo (21-27 d, 28-35 d y 36-42 d). Se evaluó el consumo de alimento, ganancia de peso, conversión alimenticia, rendimiento a la canal y rentabilidad. Se usó un diseño en bloques al azar con arreglo factorial (2x3). La relación energía/proteína no afectaron los parámetros evaluados (p≤0.05) entre tratamientos, el menor consumo de alimento (124.00 g), mayor ganancia de peso (41.00 g), mejor conversión alimenticia (3.14%), rendimiento a la canal (117.75 g) sin embargo, se observó mayor rentabilidad económica con la dieta 3000 kcal EM kg-1 / 21% PB, permitiendo, en base a la relación beneficio/costo sugerir este nivel de energía/proteína para la etapa de engorde, como una elección promisoria para la alimentación de estas aves que garantice un buen rendimiento productivo y rentabilidad económica.
Numerical study of a transient MHD flow across an oscillating vertical plate with thermal radiation and viscous dissipation
Authors: Rajaraman R. , Muthucumaraswamy R.
Published: June 2023

The flow of an electrically conducting fluid across a vertically positioned oscillating semi-boundless plate with uniform mass diffusion and temperature is examined in this study in terms of the effects of thermal radiation and viscous dissipation. The dimensionless governing equations were solved using an effective and unconditionally stable implicit finite-difference approach known as the Crank-Nicolson method. Based on the numerical results, the impacts of various physical parameter values on concentration, temperature; velocity; Sherwood numbers, Nusselt numbers and skin-friction profiles are displayed graphically and their consequences thoroughly analyzed. We observed that when the magnetic field, radiation and phase angle parameters are increased, the velocity is reduced. This shows that plate oscillation, radiation and magnetic fields affect the flow pattern significantly.
An unsteady electro-magnetohydrodynamic two-liquid plasma flow along a channel of insulating porous plates with Hall currents
Authors: Rao V.Gowri Sankara , Raju T. Linga
Published: June 2023

It is proposed to use the Hall currents to model the transient magneto-hydrodynamic two liquid flows and heat transfer of ionized gases propelled by a common pressure gradient via a horizontal channel consisting of parallel porous plates. For the distributions of velocity and temperature, the principal partial differential equations that explain heat transfer flow under the chosen constraints are resolved. Graphical representations are given for the distributions of velocity, temperature, and heat transfer rates. This research will be carried out using non-conducting porous plate’s channel.
Research on low density polyethylene (LDPE), recycled by advanced thermal analysis (DSC, TG)
Authors: Siwczyk Bartosz , Schlafka Paweł , Sąsiadek Michał , Woźniak Waldemar
Published: June 2023

This article presents the issue of recycling and maintaining the processing properties of materials made of plastics. For this purpose, samples from recycled, low-density, polyethylene were tested. The impact of the use of dyes and surface printing on the lifecycles of material and its quality was examined. For this purpose, an analysis was carried out using differential scanning calorimetry and thermos-gravimetry. It was found that the use of dyes may affect the quality of the material and increase the disposal costs of pre-used materials.
Comparison of the post-tensioned, solid, hollow block, and flat slabs in terms of economy considering different span lengths
Authors: Ahmad Omar , Sadeghi Kabir , Nouban Fatemeh
Published: June 2023

From among the several types of slabs, there is uncertainty about the most cost-effective one for structures with short, medium, and long spans. A study comparing the cost of the solid, flat, hollow block (HB), and post-tensioned (PT) slabs for 4, 6, and 8m spans was conducted using SAFE software. For each span length, the total quantities of concrete and steel bars were found and compared for 4 slabs. Then, the total cost of steel bars, concrete, blocks, tendons, and formwork was tabulated and compared. The findings revealed that the quantity of concrete in slabs with 4 and 6m spans is the least in the HB slabs, while for slabs with 8m spans, the quantity of concrete is the least in the PT slab. Besides, the quantity of steel bars in slabs with 4, 6, and 8 spans is the least in PT slabs. In terms of economy, the most cost-effective option is the flat slab for 4m spans, with savings of about 14, 9, and 17% compared to solid, HB, and PT slabs, respectively. On the other hand, for 6 and 8m spans, the most cost-effective option is the PT slab, with savings of about 10, 6, and 6% for the 6m span, and 10, 20, and 22% for 8m span compared to solid, HB, and flat slabs, respectively. Therefore, for 6m spans and more, PT slabs offer significant cost savings.
Math Chat Opportunities Abound!
Authors: Aspinall Alice
Published: June 2023

This article describes how fortuitous mathematical moments should be noticed, encouraged, embraced, and capitalized upon.
GPS: Congruency through Superposition
Authors: Chamberlin Michelle T. , Powers Robert A.
Published: June 2023

Growing Problem Solvers provides four original, related, classroom-ready mathematical tasks, one for each grade band. Together, these tasks illustrate the trajectory of learners’ growth as problem solvers across their years of school mathematics.
Problems to Ponder
Authors: Johns Justin Gregory , Harrow Chris , Nikolai Peter
Published: June 2023

Problems to Ponder provides 28 varying, classroom-ready mathematics problems that collectively span PK–12, arranged in the order of the grade level. Answers to the problems are available online. Individuals are encouraged to submit a problem or a collection of problems directly to mtlt@nctm.org. If published, the authors of problems will be acknowledged.
Teaching Is a Journey: Cracking Eggs
Authors: Martinez Alexandra
Published: June 2023

This department provides a space for current and past PK–12 teachers of mathematics to connect with other teachers of mathematics through their stories that lend personal and professional support.
Criminal Acts Against The Law Of Corruption (Case Study Medan District Court No. 45 / Pid.Sus-TPK/2021 / Fr.Mdn jo Medan High Court case No. 33/Pid.Sus-TPK/2021 / PT.Mdn)
Authors: Darmayanti Deby , Ruslan Ruslan , Sahputra Rilawadi
Published: June 2023

In essence, the land has a very important meaning for human life, because the land is the main foundation of all activities carried out. In accordance with the ownership and use of land in Indonesia, there are lands that are controlled by state-owned institutions, one of which is land controlled by PT.Kereta Api Indonesia (Persero). State-controlled land PT.Kereta Api Indonesia (Persero) which was originally to support the potential development process of PT.Kereta Api Indonesia (Persero) itself, now there are many houses and community business activities throughout Indonesia, one of which is in the city of Medan, North Sumatra province, there are many areas on the edge of the railway where on each edge there are houses and business activities of residents who are renting from the land assets of PT.Kereta Api Indonesia (Persero). The problem raised in this thesis is the lease of land assets of PT.KAI (persero) Division I North Sumatra which led to the conviction in the verdict of committing acts against the law of corruption, because they do not want to fulfill their obligations to pay rent, while the requirements of Article 2 and Article 3 of the UUPTPK are acts against the law (Wederrechtelijkheid) or abuse of control that begins with a violation of procedure or, contrary to the rules or deviations from the authority provided for in the law on procurement of government goods and services, the procedure starts from planning, the need until the completion of all activities to obtain government goods/services with the aim of enriching themselves or benefiting themselves, causing financial losses to the state. While the unlawful acts committed by the defendant include the scope of civil (Onrecht Matiq Overheidsdaad) which is private (vide Article 1365 of the Civil Code) and can file a tort claim in the form of reimbursement of costs, losses, and interest as in Article 1243 of the Civil Code and Article 1267 of the Civil Code.
Sífilis infecciosa en la ciudad de Recreo, Departamento La Paz, Provincia de Catamarca, Argentina
Authors: Cooke Paula María , Martínez María Sol , Cejas Mateo Ezequiel , Caula Cinthya
Published: June 2023

La sífilis, aun siendo fácil de diagnosticar y tratar, es causa de morbilidad y mortalidad en el mundo y su prevalencia sigue en aumento. Objetivos: Determinar la proporción de infectados con Treponema pallidum según sexo y edad y su relación con factores de riesgo. Métodos: 148 pacientes (47% varones, 53% mujeres, entre 16 y 60 años), pruebas de VDRL y ELISA, registro de datos demográficos, clínicos, conductas de riesgo. Resultados: primera prueba de VDRL en el 78,38% de los participantes. Casos de sífilis confirmados: 10 (6,76%); 70% mujeres, entre ellas 57,4% embarazadas; 70% entre 16 y 24 años de edad; 50% con nivel secundario completo y con VDRL previa; 70% con pareja sexual estable; edad temprana de inicio de actividad sexual (≤ 16); ausencia de uso de preservativo siempre. Conclusión: Se evidencia la necesidad de realizar controles serológicos e implementar un abordaje interdisciplinario en la prevención y tratamiento, principalmente en jóvenes.
COVID-19 infection in a patient with Follicular non-Hodgkin Lymphoma. A Case Report
Authors:   Multidisciplinary Research Center for Malignant Hematological Diseases (CCMHM), Victor Babes University of Medicine and Pharmacy, Timisoara, Romania, POPOVICI Despina Calamar , LAZAR Sandra Monica ,   Department of Hematology, Emergency Municipal Hospital Timisoara, Romania, ILIE Alina Maria ,   Department of Hematology, Emergency Municipal Hospital Timisoara, Romania, DAVID Larisa Marina ,   Department of Hematology, Emergency Municipal Hospital Timisoara, Romania, SARAU Oana ,   Department of Hematology, Emergency Municipal Hospital Timisoara, Romania, OROS Dacian Nicolae ,   Multidisciplinary Research Center for Malignant Hematological Diseases (CCMHM), Victor Babes University of Medicine and Pharmacy, Timisoara, Romania, IONITA Claudiu Octavian ,   Department IX of Surgery I, Discipline of Surgical Semiology I and Thoracic Surgery, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania, DEMA Sorin Adalbert ,   Department of Radiotherapy, Emergency Municipal Hospital Timisoara, Romania, BALICA Nicolae Constantin ,   Department IX of Surgery I, Discipline of ENT, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania, IONITA Ioana ,   Multidisciplinary Research Center for Malignant Hematological Diseases (CCMHM), Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
Published: June 2023

Follicular non-Hodgkin Lymphoma (FNHL) is the most common type of indolent non-Hodgkin Lymphomas (NHL) that develops from abnormal B-lymphocyte that form follicle-like clusters inside the lymph nodes (1). The prevalence of FNHL is estimated around 1 in 3000 patients, being usually encountered in elderly, 60 years old patients and diagnosed in advanced stages when monoclonal antibodies alone or combined with other chemotherapy agents are needed (2). Recent studies about COVID-19 infection prognosis suggest that oncologic patients are at high risk of morbidity and mortality due to SARS-CoV-2 infection, partially because of the secondary immune deficiency due to malignant pathology itself, but also to the accumulated toxicity secondary to the immuno-chemotherapy treatment. (3). This case report describes a young female patient with FNHL with Bulky abdominal tumoral mass detected at CT scan, in Complete Remission after immune-chemotherapy treatment, contacting COVID-19 twice, first in 2020 and second time in 2022. Even if the patient has been vaccinated against SARS-CoV-2 in late 2021, she did not develop an increased titer of either SPIKE anti-protein neutralizing antibodies (Protein S) or anti-Nucleocapsid IgG antibodies.
Cold Agglutinin Disease – Diagnostic and Therapeutic Challenges in the Clinical Setting
Authors:   UMF Carol Davila, Bucharest, Romania, SAGUNA Carmen , ENACHE Alexandra Oana ,   Spital Clinic Coltea, Departament Hematologie, Bucharest, Romania, BUBULETE Maria ,   Spital Clinic Coltea, Departament Hematologie, Bucharest, Romania, RACILA Mariana ,   Spital Clinic Coltea, Departament Hematologie, Bucharest, Romania, COLITA Andrei ,   UMF Carol Davila, Bucharest, Romania, BERBEC Nicoleta Mariana ,   UMF Carol Davila, Bucharest, Romania, MARIN Virginia ,   Spital Clinic Coltea, Departament Hematologie, Bucharest, Romania, BALAN Elena ,   Spital Clinic Coltea, Departament Hematologie, Bucharest, Romania, MANOLACHE Raluca Mihaela ,   Spital Clinic Coltea, Departament Hematologie, Bucharest, Romania, BARBU Doina ,   Spital Clinic Coltea, Departament Hematologie, Bucharest, Romania, ANGELESCU Silvana ,   UMF Carol Davila, Bucharest, Romania, STANCA Oana ,   UMF Carol Davila, Bucharest, Romania, LUPU Anca Roxana ,   UMF Carol Davila, Bucharest, Romania
Published: June 2023

Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia (AIHA), in which IgM specific antibodies cause the agglutination of red blood cells (RBCs) at temperatures < 37°C and activate the classical pathway of complement leading to extravascular hemolysis, C3b-coated RBCs are phagocytosed by the macrophages of the reticuloendothelial system (predominantly in the liver). Up to date there are two clinical-pathologic entities recognized as distinct with different therapeutic implications: cold agglutinin disease and cold agglutinin syndrome (CAS). Primary CAD is recognised as clonal B-cell lymphoproliferative disorder of the bone marrow, clinical and imagistic evidence of associated malignancy. CAS arises in the setting of an underlying disorder such as infection, autoimmune disease or malignancy (non Hodgkin lymphoma or other malignant process). The diagnosis of CAD is often delayed due to the unpredictable clinical course. In spite of the current therapeutic options which are directed at the pathogenic B cells or the complement system, the low response rates and frequent relapses lead to challenges regarding the management of this disease.
flexCAT: 计算机化自适应测验开发平台
Authors: Tu Dongbo , Luo Fen , Wang Daxun
Published: June 2023

计算机化自适应测验（CAT）是一种全新的测验模式,采用了“因人施测”“量体裁衣”的自适应测量思想。与传统纸笔测验相比, 它具有提高测量精度，减少测验长度，保证测验安全等优势，因此深受国内外研究者和实践者的推崇。但CAT的平台搭建涉及复杂的统计测量理论以及繁琐的数值计算，阻碍了CAT在实践中应用推广。本文主要介绍计算机化自适应测验开发平台——flexCAT，用户借助flexCAT平台，利用便捷的人机交互页面可以快速搭建自己的CAT系统。本文将从优势特点，基础理论，模块功能等方面介绍国内首个基于网络的计算机化自适应测验开发平台——flexCAT，旨在为教育、心理等领域研究及应用人员免费提供自适应测试平台开发服务，进一步推动心理与教育测量理论与技术在中国的发展。flexCAT平台的网址为：http://www.psychometrics-studio.cn/app/cat_demo/index.html?Id=false&Block=false
Influence of organic agricultural production on the condition of surface water
Authors: Žolynaitė Rasa , Pocius Skirmantas , Česonienė Laima
Published: June 2023

Agriculture and its methods of operation constantly influence the quality of water of surface water bodies. It was established in 2021 that in Lithuania, 63% of water bodies of the river and 64% of the lake categories are classified as risk water bodies and do not meet the good condition criteria. One of the main factors leading to the deterioration of the condition of surface water bodies is the continuing and increasing diffuse pollution, mainly from agricultural activities, together with pollution from agriculture; also, the condition in some water bodies deteriorates because of concentrated pollution, persistent effects of hydromorphological changes in surface water bodies, natural processes, and changing climatic conditions. This study aimed to determine the degree at which the ecological method of agricultural production affects the nearby surface water bodies. The obtained results show that the larger the area of organic farms from the entire area of the nutrient basin of a lake, the lower the values of biochemical oxygen consumption, total phosphorus, phosphate phosphorus, nitrate nitrogen, and total nitrogen concentrations. The ecological method of agricultural production has a positive effect on the condition of surface water bodies.
The utilization of basal luteinizing hormone in combination with the basal luteinizing hormone and follicle-stimulating hormone ratio as a diagnostic tool for central precocious puberty in girls
Authors: Chotipakornkul Nuntika , Onsoi Witchuwan , Numsriskulrat Nattakarn , Aroonparkmongkol Suphab , Supornsilchai Vichit , Srilanchakon Khomsak
Published: June 2023

Purpose: Intravenous gonadotropin-releasing hormone (IV GnRH) testing is the gold standard for confirming a central precocious puberty (CPP) diagnosis. However, this test is not widely available commercially. Therefore, our study aim was to establish cutoff values for basal gonadotropin level and gonadotrophin responses to a 100-μg subcutaneous IV GnRH test that can distinguish between CPP and premature thelarche (PT) to discover a simple method to detect CPP.Methods: Girls between the ages of 6 and 8 years who attended the pediatric endocrinology outpatient clinic at our tertiary hospital between 2019 and 2022 were included in this study. They were evaluated for breast development, and a subcutaneous 100-μg GnRH test was administered by measuring the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in blood samples at baseline and then 30, 60, 90, and 120 minutes after injection. CPP is characterized by increased height velocity, advanced bone age, and progression of breast development. The cutoff value for diagnosis of CPP was determined using a receiver operating characteristic (ROC) analysis.Results: In 86 Thai girls (56 with CPP and 30 with PT), the ROC analysis showed 71.4% and 100% sensitivity and specificity, respectively, for basal LH (cutoff ≥ 0.2 IU/L) plus the basal LH/FSH ratio (cutoff ≥ 0.1). The optimal cutoff values for peak LH (cutoff ≥ 7 IU/L) demonstrated a sensitivity of 94.6% and a specificity of 100%, whereas the LH value at 30 and 60 minutes after injection (cutoff ≥ 6 IU/L) demonstrated sensitivities of 92.9% and 94.6% and a specificity of 100%, respectively Conclusion: Combining the basal LH (cutoff: 0.2 IU/L) and the basal LH/FSH ratio (cutoff: 0.1) can easily and cost-effectively diagnose CPP in a girl in breast Tanner stage II.
Molecular basis and genetic testing strategies for diagnosing 21-hydroxylase deficiency, including CAH-X syndrome
Authors: Kim Ja Hye , Kim Gu-Hwan , Yoo Han-Wook , Choi Jin-Ho
Published: June 2023

Congenital adrenal hyperplasia (CAH) is a group of autosomally recessive disorders that result from impaired synthesis of glucocorticoid and mineralocorticoid. Most cases (~95%) are caused by mutations in the CYP21A2 gene, which encodes steroid 21-hydroxylase. CAH patients manifest a wide phenotypic spectrum according to their degree of residual enzyme activity. CYP21A2 and its pseudogene (CYP21A1P) are located 30 kb apart in the 6q21.3 region and share approximately 98% of their sequences in the coding region. Both genes are aligned in tandem with the C4, SKT19, and TNX genes, forming 2 segments of the RCCX modules that are arranged as STK19-C4A-CYP21A1P-TNXA-STK19B-C4B-CYP21A2-TNXB. The high sequence homology between the active gene and pseudogene leads to frequent microconversions and large rearrangements through intergenic recombination. The TNXB gene encodes an extracellular matrix glycoprotein, tenascin-X (TNX), and defects in TNXB cause Ehlers-Danlos syndrome. Deletions affecting both CYP21A2 and TNXB result in a contiguous gene deletion syndrome known as CAH-X syndrome. Because of the high homology between CYP21A2 and CYP21A1P, genetic testing for CAH should include an evaluation of copy number variations, as well as Sanger sequencing. Although it poses challenges for genetic testing, a large number of mutations and their associated phenotypes have been identified, which has helped to establish genotype-phenotype correlations. The genotype is helpful for guiding early treatment, predicting the clinical phenotype and prognosis, and providing genetic counseling. In particular, it can help ensure proper management of the potential complications of CAH-X syndrome, such as musculoskeletal and cardiac defects. This review focuses on the molecular pathophysiology and genetic diagnosis of 21-hydroxylase deficiency and highlights genetic testing strategies for CAH-X syndrome.
Sintesis Nanoemulsi dari Ekstrak Kulit Manggis dengan Metode Energi Tinggi
Authors: Rizki Tri , Yasni Sedarnawati , Muhandri Tjahja , Yuliani Sri
Published: June 2023

Mangosteen (Garcinia mangostana L.) has become the main agricultural products contributing to the largest annual foreign exchange from the fruit category. Mangosteen rind contains xanthone compounds as a source of antioxidants, with α-mangostin and γ-mangostin, as the main components which are used as traditional and modern ingredients to treat various diseases. However, mangosteen rind extract has low bioavailability thus resulting in low effectiveness in the application. This study aimed to find the ideal formulation for producing the extract and nanoemulsion of mangosteen peel. The research carried out in two stages: extraction of mangosteen peel and production of nanoemulsion. Ethanol 70% was the best for mangosteen rind extraction, with a percentage yield of 40.96±0.51%, antioxidant activity of  5708.33±159.57 µg AEAC/mL sample, and total xanthones of 373.84±6.49 µg/mL sample. The use of Tween 20 at nanoemulsion production gave the best test results, with particle size of 10.58±1.25 nm, polydispersity index 0.27±0.03, zeta potential -2.34±0.46 mV, and total xanthones 35,28±0,04 µg/mL sample.
Sensory Mapping of UHT Milk with Single-Origin Chocolate
Authors: Hunaefi Dase , Tarigan Sures Setiadi , Dwinawati Elisabeth , Sholehuddin Zen Fauzan , Taqi Fahim Muchammad , Zeller Yves Henri Marie
Published: June 2023

Like coffee, the popularity of speciality chocolate flavour or single-origin chocolate is growing in the Indonesian market. At the same time, sensory characteristic of the chocolate flavors is becoming more important, affecting both the taste and marketing of food product with chocolate flavor. As such, this study aims to describe UHT milk with single-origin chocolate through a complete sensory attribute mapping. A focus group discussion (FGD) resulted 15 texture attributes, 11 need-state attributes, 15 music attributes, 17 emotion attributes, 11 flavor attributes, and additional 70 color attributes. The complete sensory mapping test was performed using the CATA method based on attributes obtained from the FGD and analyzed using XLSTAT. The resulting product descriptions are as follows: cocoa Flores products were associated with soft and light textures, a need to focus and provide energy, pleasant classical and pop music, relaxed and warm emotions, flavors of ice cream, and light green, purple and brown colors. Cocoa Bali was linked to a smooth but rather hard texture, a need for rest and exercise, a cheerful musical style, happy emotions, a biscuit flavor, and a pink-yellow color. Cocoa Aceh was correlated with smooth and soft textures, state-of-the-art rest, energetic music, relaxed and energetic emotions, creamy flavor, and blue color. Meanwhile, cocoa Java was attributed with a smooth but rather hard texture, a state-of-the-art mood booster, cheerful music, relaxed emotions, ice cream flavor, and red-brown color. Thus, understanding specific sensory characteristics enables the producer to improve the product's development and marketing.
Potensi Ekstrak Kulit Daun Lidah Buaya sebagai Bahan Antibakteri pada Active Film Berbasis Pektin
Authors: Sobarsa Herza Govina , Suyatma Nugraha Edhi , Kusumaningrum Harsi Dewantari
Published: June 2023

Edible film is a thin layer made of materials that can be consumed, protect from moisture and gas, and extend the shelf life of food products. The criteria for the materials for edible films are able to withstand gas and water permeation, colorless, do not cause changes in the characteristics of the packaged food products, and are safe for consumption. One of the ingredients that can be added to edible film is Aloe vera skin. The study aimed to determine the effect of increasing the aloe vera leaf extract concentration and producing an antibacterial edible film with the appropriate mechanical and antibacterial inhibitory properties. The study used a completely randomized design. Observations of film’s characteristics included mechanical and physical properties i.e., tensile strength, elongation, modulus of elasticity, water vapor transmission rate, thickness, CIE color values, and the inhibition activity of bacterial growth. The obtained data were analyzed using analysis of variance (ANOVA), and if there was a significant difference, Duncan’s Multiple Range Test was applied. The best edible film was obtained by adding aloe vera skin extract at a concentration of 4 times the Minimum Inhibitory Concentration (MIC). This film had a tensile strength of 0.878 MPa, elongation of 75.56%, modulus of elasticity of 1.16 MPa, thickness of 0.153 mm, Water Vapour Transmission Rate (WVTR) of 22.53 g/(m2.day), inhibition activity of 31.85 mm, and color value CIE ∆L* = 18.61, ∆a* = 0.98, ∆b* = 29.57, ∆E* = 38.63, ∆C*= 33.59, and ∆H* =  -87.23 with the white plate color of chromameter used as a standard.
Optimasi Formula Pempek dengan Penambahan Pasta Isolat Protein Kedelai Berdasarkan Preferensi Konsumen
Authors: Amal Bayu Ikhlasul , Hermanianto Joko , Hunaefi Dase
Published: June 2023

Pempek is one of the traditional foods of South Sumatra which is a processed food made from fish and tapioca flour. The chewy texture of pempek is very popular among consumers, but the addition of too much tapioca flour can make pempek has a hard texture. One alternative to improve the texture of pempek is using isolate soy protein (ISP). This study aims to obtain the optimum formulation of pempek added with isolate soy protein based on consumer preferences and identify the ideal attributes sensory of pempek. The method used in this research is the preparation of the formulation with the RSM using the Design-Expert 13 application, profiling attributes with FGD, testing physical texture with Texture Analyzer, hedonic test, data analysis, CATA and hedonic tests for the optimum formulation, and proximate test for the selected formulation. Based on the results of the analysis, two formulations of pempek were selected from 17 formulas of pempek with the highest desirability values, 0.84 (sample 179) and 0.74 (sample 952). Based on the results of the CATA test, sample 952 has the closest sensory attributes to ideal pempek based on consumer preferences with favorite sensory attributes being artificial aroma (MSG), umami taste, and chewy texture.
Resource Use Efficiency and Cleaner Agricultural Production: An Application of Technical Inefficiency Effects Model for Paddy Producing Zones of West Bengal
Authors: Maity Shrabanti , Sinha Anup , Rath Mithun Kumar , Barlaskar Ummey Rummana
Published: June 2023

It is possible to enhancement of agricultural productivity with environmental sustainability through efficient utilization of resources. This hypothesis is examined by the efficiency and the responsible factors for controlling inefficiency of the farms. The empirical analyses are conducted based on the secondary data of 14 960 farms scattered into five different paddy producing zones of West Bengal, India. The Efficiency estimates disclose that clayey soil texture zone is the most efficient and sandy and gravelly soil texture zone is the least efficient concerning paddy production. The study concludes with appropriate policy implications that the inefficiency on the part of the farms is caused by inefficient utilization of the chemical fertilizers, viz., nitrogen and potassium and insecticides and by the efficient utilization of this the farm can increase its productivity with environmental sustainability.
Polycystic liver disease: an overview of clinical manifestations, diagnosis, and treatment
Authors: Jeong Joonho , Park Hyun Joon
Published: June 2023

Polycystic liver disease (PLD) is a hereditary disease characterized by the presence of 20 or more liver cysts. It is classified into three types: isolated autosomal dominant PLD, PLD with autosomal dominant polycystic kidney disease, and PLD with autosomal recessive polycystic kidney disease. Genetic alterations, ciliary dysfunction of the biliary epithelial cells, and aberrant cell signaling pathways are the main factors contributing to the pathophysiology of PLD; however, other complicated mechanisms are also involved. The Gigot and Schnelldorfer classifications are widely used in clinical practice. Most patients with PLD are asymptomatic; however, a few patients with advanced-stage disease may develop symptoms and complications that impair their quality of life and require treatment. The known treatment options for PLD are somatostatin analogues, aspiration with sclerotherapy, fenestration, hepatic resection, and liver transplantation. Although liver transplantation remains the only curative treatment for PLD, medical therapies are gradually being developed with the increasing knowledge of the disease’s pathophysiology. This review focuses on the clinical manifestations and diagnosis of PLD, as well as treatment strategies, to support clinicians regarding the clinical management of the disease.
O papel dos contos de fadas no processo grupal com crianças em vulnerabilidade social
Authors: Moura Letícia Domingues , Rocha Thaina Aparecida Barbosa , Salles Rodrigo Jorge
Published: June 2023

Os contos de fadas se mantêm através dos séculos e foram aos poucos sendo adaptados à infância. A literatura indica que os contos de fadas possibilitam que as crianças internalizem e elaborem conflitos, refletindo sobre possíveis soluções, podendo assim desenvolver sua própria capacidade de resolução de problemas. O presente estudo teve como objetivo compreender o papel desempenhado pelos contos de fadas no processo de atendimento grupal infantil. Trata-se de uma pesquisa qualitativa e delineamento clínico interventivo. Participaram da pesquisa sete crianças de 6 a 10 anos de idade, matriculadas em uma instituição de contra turno, que atende crianças em risco ou vulnerabilidade social. Foram trabalhados três contos de fadas em 12 sessões de atendimentos em grupo semanais. Além das anotações realizadas ao longo das sessões, para coleta de dados foi adotado o uso de um roteiro de anamnese e um questionário sociodemográfico, preenchidos junto aos responsáveis pelas crianças. Os dados coletados foram associados aos registros de campo elaborados ao longo das sessões e analisados a partir da proposta de análise de conteúdo temática. Os resultados indicam que os contos de fadas exercem uma função mediadora que auxilia na expressão dos conflitos infantis por meio da dimensão simbólica. O aprendizado internalizado adquirido a partir da relação com os contos possibilitou que as crianças criassem personagens que buscam o enfrentamento de desigualdades e superação de dificuldades sociais, evidenciando o papel dos contos de fadas na expressão e elaboração dos conflitos de crianças que vivenciam contextos sociais marcados pelo abandono, violência e vulnerabilidade.
Transport Policy as a Way to Strengthen Geostrategic Position – A Review of Vienna as a Centre of Air and High-Speed Rail Transport in Central Europe
Authors: Stellner František , Vokoun Marek , Szobi Pavel , Kasa Marek
Published: June 2023

Vienna’s geostrategic importance fluctuated through the ages because of the power clashes and subsequent political and socio-economic impacts on the population. This paper assesses its current position in a historical context and then focuses more on the socio-economic dimensions such as interconnectedness and other transport aspects of the geostrategic position. Air and environmentally friendlier modes of passenger transport like high-speed rail are considered and analysed in the European context. This paper also reviews the results and issues dealing with the development of the Vienna Airport and the progress of high-speed railway projects in the Central European Economies (CEEs) after the European Union’s enlargement in 2004. The results suggest that after a restoration period of Vienna’s geostrategic position between 1995–2005, there is currently only a moderate and slowly growing exercise of power, control or influence over the CEEs. The results suggest that there is competition from busier German hub airports as well as the growing importance of CEE airports in transit and growing passenger transport performance figures. The lack of environmentally friendly high-speed infrastructure as a viable option instead of the fastest air travel is preventing Vienna to strengthen its strategic position. Its strategic importance is highly affected by the underdeveloped transport networks in CEEs and the future development of the Vienna Airport as a major transport hub.
Multivariate statistical analysis of the alluvial aquifer of Tadjenanet-Chelghoum Laid (Eastern Algeria)
Authors: Dib Imane , Khedidja Abdelhamid , Chettah Wahid
Published: June 2023

The region of Chelghoum Laid - Tadjenanet is located in eastern Algeria, in the high plains. This area is characterized by a varied age (Mio-Plio-Quaternary) formations and the human demand is answered by the groundwater hosted into the superficial aquifer of the Mio-Plio-Quaternary formations. However, the overexploitation of this aquifer leads to a drop in the piezometric surface and an increase in salinity. of this aquifer leads to a drop in the piezometric surface and an increase in the salinity of the water. A hydrochemical study using characteristic ratios and statistical tools such as principal component analysis and hierarchical ascending classification, was performed using 28 water samples. Chemical analyzes show that the waters of this aquifer are of the calcium bicarbonate type on the limits of the study area, and calcium sulphate to sodium chloride in the centre. The spatial evolution of chemical water facies is explained by the phenomenon of dissolution and ion exchange between the alkali metals and alkaline earth metals coinciding with the West-East flow direction. The application of the various tools shows that the aquifer is recharged by precipitation at the plains border, where the water acquires its original mineralization from the carbonate formations, and becomes more mineralized in chlorides, sodium and sulphates concentrations in contact with the salt-bearing terrigenous formations of the Mio-Plio-Quaternary. The salinization of the waters seems to be mainly due to the dissolution of gypsum, halite and epsomite. The application of the ascending hierarchical classification and the principal component analysis shows the existence of two groups of water whose salinity increases from the borders towards the center of the plain following the main flow direction.
Kystbarometeret måler bærekraft langs kysten av Nord-Norge
Authors: Fauchald Per
Published: June 2023

Kystbarometeret bruker ni indikatorer til å måle bærekraft i kystkommunene i Nord-Norge. Hva menes med bærekraft, og kan det egentlig måles?
Barentshavet under oppvarming – sårbarhet og risiko for økosystemer
Authors: Primicerio Raul
Published: June 2023

Et varmere klima fører til raske temperaturendringer i Arktis, med hurtig tap av havis og endrede habitater for mange arter. Varmere havstrømmer og smelting av havis åpner samtidig for økt menneskelig tilstedeværelse og bruk av arktiske havområder. Slike endringer påvirker hvordan arktiske økosystemer eksponeres for miljøstressorer, og fører til økt sårbarhet i disse systemene. Man ser dermed et tydeligere behov for en mer klimatilpasset forvaltning.
Potential drug-drug interactions and their associated factors in hospitalized COVID-19 patients with comorbidities
Authors: Rahmadani Imanda Dyah , Irawati Sylvi , Wibowo Yosi Irawati , Setiadi Adji Prayitno
Published: June 2023

Background

Hospitalized COVID-19 patients with comorbidities receive more complex drug therapy. This increases the probability of potential drug-drug interactions (pDDIs). Studies on pDDIs in hospitalized patients with COVID-19 in countries with limited resources like Indonesia during the later period of the disease are still limited. This study aims to identify the pattern of pDDIs in hospitalized COVID-19 patients with comorbidities and their associated factors, especially in the second wave of the disease in Indonesia.

Methods

This study was a longitudinal-retrospective study observing hospitalized COVID-19 patients with comorbidities using medical record data in June–August 2021 at a public hospital in a region in Indonesia. pDDIs were identified using the Lexicomp® database. Data were descriptively analyzed. Factors associated with important pDDIs were analyzed in multivariate logistic regression model.

Results

A total of 258 patients with a mean age of 56.99 ± 11.94 years met the inclusion criteria. Diabetes mellitus was the most common comorbidity experienced by 58.14% of the patients. More than 70% of the patients had one comorbidity and the average number of administered drugs was 9.55 ± 2.71 items per patient. Type D pDDIs, which required modification of therapeutic regimens, amounted to 21.55% of the total interactions. Only the number of drugs was significantly and independently associated with type D pDDIs (adjusted odds ratio 1.47 [1.23–1.75], p < 0.01).

Conclusion

The drugs involved in the pDDIs of hospitalized COVID-19 patients with comorbidities may differ depending on the disease periods, hospital settings, or countries. This study was small, single center, and of short duration. However, it may give a glimpse of important pDDIs during the delta variant of COVID-19 in a similar limited-resource setting. Further studies are needed to confirm the clinical significance of these pDDIs.
La inactividad de la Administración migratoria como omisión inconstitucional por afectación de derechos fundamentales y su configuración jurisprudencial en Chile
Authors: Matheus Hidalgo Mayerlin
Published: June 2023

Para algunos autores el único agente de omisión inconstitucional sería el legislador por la inmediata vinculación de este con la Constitución. Sin embargo, en este trabajo demostraremos, que en contra de tal posición, al menos en Chile, jurisprudencialmente, se admite que también la Administración es agente de omisión inconstitucional por su capacidad de violar directamente derechos fundamentales.
Criterios y estándares para el control judicial de las sanciones administrativas
Authors: Cordero Quinzacara Eduardo , Gómez Gónzalez Rosa
Published: June 2023

El trabajo tiene por objeto establecer el sistema de control judicial de los actos administrativos en Chile, en el marco del sistema general de control de los actos formales de la Administración. En tal sentido, se afirma que se trata de un control de derecho estricto que se extiende tanto a los vicios de legalidad como de constitucionalidad, abarcando los ámbitos de discrecionalidad que el legislador entrega a los órganos administrativos al momento de ejercer la potestad sancionadora (no se trata de potestades plenamente regladas), aun cuando no es posible sustituir la decisión administrativa, salvo en la determinación del quantum de la sanción, conforme a la regla del precedente.
Multas coercitivas: determinación de su naturaleza jurídica y efectos. Análisis a partir del artículo 38 Ley General de Telecomunicaciones
Authors: Helfmann Martini Carolina
Published: June 2023

Este trabajo tiene por propósito el estudio y la determinación de la naturaleza jurídica de las multas coercitivas y el análisis las principales consecuencias jurídicas que se derivan de la misma. Para ello, se examinará si las multas coercitivas resultan más asimilables en su naturaleza a las sanciones administrativas o si, en cambio, se asemejan a los mecanismos de ejecución de los actos administrativos. Luego, en cuanto a las consecuencias jurídicas: se analizará la posibilidad de aplicar de manera conjunta sanciones y multas coercitivas; el momento a partir del cual la multa coercitiva debe ser contabilizada; y, por último, los principales elementos que componen el régimen jurídico de las multas coercitivas concebidas como sanciones administrativas. Este análisis será realizado tomando como hipótesis de estudio lo dispuesto en el artículo 38 de la Ley General de Telecomunicaciones.
Hacia una objetivización del principio de proporcionalidad en el control de las sanciones administrativas
Authors: Izquierdo Serrano Tomás , Valdivia Olivares José Miguel
Published: June 2023

El control judicial de la determinación y cuantificación de las sanciones administrativas a través del principio de proporcionalidad ha adquirido relevancia práctica en el derecho chileno. Su aplicación, no obstante, denota cierta insuficiencia de criterios objetivos, arriesgando la eficacia del régimen sancionatorio. Este trabajo pretende identificar parámetros dotados de cierta objetividad que, sin obviar su importancia, permitan racionalizar el empleo del principio de proporcionalidad.
Scope of Teledentistry during the Trying Times of COVID-19 Pandemic: A Patient Perspective Questionnaire Survey
Authors: Prabakar Manasa , Ramakrishnan Hemalatha , Parthiban Sathya Prathiba , Palani Dhivakar Cheyyar , Palayathan Indumathi
Published: June 2023

Introduction: Teledentistry has provided a glimmer of hope for patients who require treatment, but are limited to their homes owing to Coronavirus Disease-2019 (COVID-19) restrictions. Like any other professional careers, dentistry also had to switch to a new normal mode of consultation and teledentistry came to its aid. With the support of advanced technologies dental care was made possible even though face to face interactions were to be refrained due to the curfew restrictions. Aim: To assess the scope of teledentistry from a patient’s perspective. Materials and Methods: The survey was designed as a descriptive cross-sectional study conducted in the Department of Periodontics, Karpaga Vinayaga Institute of Dental Sciences, Chengelpet, Tamil Nadu, on dental patients of Chennai, India, from April 2021 to May 2021 who made use of Telemedicine for dental consultation. The study population included those who sought teledentistry and the study included 100 participants. A computer aided self-administered questionnaire was designed and validated. Practicing dentists were requested to circulate a questionnaire containing 10 questions that assessed scope of teledentistry from patient’s perspective, to their patients at the end of their teleconsultation after obtaining consent. A total of 94 responses were obtained successfully out of 100 participants. Descriptive analysis of the obtained data was done using International Business Machines Statistical Package for the Social Sciences (IBM SPSS) software version 22.0. Results: The mean±Standard Deviation (SD) age of the study participants was 33±2.5 years, there were 51 males and 43 females. A 57.5% (n=54) of individuals made the best use of teledentistry during the lockdown and 59.6% (n=56) of the respondents felt that teledentistry was safe as it prevented the risk of unnecessary exposure and cross-infection. Of all, 79 (84.04%) respondents answered that they support teledentistry in the future. Suggestions were received requesting reduction in consultation fee and to increase consultation timings. Conclusion: Teledentistry proved to be an excellent alternate mode of dental service during the COVID-19 pandemic crisis. Moreover, it helped to bring down the cross-infection and made health services available to people caught up in inaccessible areas thus, making teledentistry a valuable tool that can be used on a day to day basis