bluuebunny/crossref_metadata_2025 huggingface dataset:
A EDUCAÇÃO E A COLONIALIDADE: A ANÁLISE DE IMAGENS ENQUANTO INSTRUMENTO CRÍTICO PARA O ENFRENTAMENTO DAS IDEOLOGIAS RACIAIS
Authors: Souza Suely dos Santos
Published: August 2019

Este trabalho apresenta uma reflexão acerca da dominação colonial ideológica que perdura no espaço e no tempo e se estrutura sutil e cruel no imaginário popular e na estrutura social e institucional. Tem como objetivo apresentar a necessidade e urgência de se extinguir tal visão para construirmos uma sociedade em que os direitos sejam iguais para toda a população, e a educação como instrumento primordial nessa luta. Nessa perspectiva, utiliza-se da análise de imagem enquanto instrumento auxiliar crítico para a educação, com a intenção de descortinar ideologias raciais que se escondem por detras de imagens utilizadas no cotidiano pedagógico. Para isso, utilizou-se da análise iconográfica de Panofsky (2002) para nortear a investigação que nos instrumentaliza na compreensão dos significados existentes no texto imagético. Nessa perspectiva, conclui-se que imagens utilizadas no contexto escolar ainda hoje difundem ideologias raciais que precisam ser entendidas, descortinadas e desconstruídas considera-se que, não obstante as muitas lutas e reflexões empreendidas pelos movimentos sociais negros, pela academia, e regulamentado por lei, esses livros ainda reproduzem e disseminam concepções ideológicas etnocêntricas que precisam ser erradicadas na busca pela construção de uma sociedade realmente justa e igualitária
A AUTOMUTILAÇÃO: O DESENHO COMO FORMA DE TRATAMENTO DIVERSO
Authors: Da França Irlana de Jesus
Published: August 2019

A automutilação é um transtorno psicológico caracterizado pelo sofrimento emocional do indivíduo que não consegue lidar com as mudanças de valores e descobertas que aparecem no decorrer de sua vivência. Ao tempo que este comportamento é utilizado como válvula de escape para aliviar as angústias diárias, também recai, de forma negativa, nas relações profissionais e pessoais, visto que, uma de suas consequências é o isolamento. Diante disso, o presente texto, possui por objetivo geral relacionar à automutilação com os tratamentos terapêuticos intermediados pela arte, tendo como enfoque o desenho, e como objetivos específicos a demonstração da automutilação, desmistificação do pensamento, verificando suas possíveis causas e consequências, bem como a viabilidade de tratamento diverso. A pesquisa aqui realizada se dará como base para a realização de um estudo de campo sobre a dimensão no que tange a automutilação nos Colégios de Ensino Médio da cidade de Cruz das Almas-BA, e por fim, analisar e aplicar, juntamente com o Centro de Referência Assistência Social - CRAS o método aqui abordado.
Ethics for Laboratory Medicine
Authors: Gronowski Ann M , Budelier Melissa M , Campbell Sheldon M
Published: August 2019

BACKGROUND

Laboratory medicine, like other areas of medicine, is obliged to adhere to high ethical standards. There are particular ethical issues that are unique to laboratory medicine and other areas in which ethical issues uniquely impact laboratory practice. Despite this, there is variability in ethics education within the profession. This review provides a foundation for the study of ethics within laboratory medicine.

CONTENT

The Belmont Report identifies 3 core principles in biomedical ethics: respect for persons (including autonomy), beneficence (and its corollary nonmalfeasance), and justice. These core principles must be adhered to in laboratory medicine. Informed consent is vital to maintain patient autonomy. However, balancing patient autonomy with the desire for beneficence can sometimes be difficult when patients refuse testing or treatment. The use of leftover or banked samples is fundamental to the ability to do research, create reference intervals, and develop new tests, but it creates problems with consent. Advances in genetic testing have created unique ethical issues regarding privacy, incidental findings, and informed consent. As in other professions, the emergence of highly contagious and deadly infectious diseases poses a difficult ethical dilemma of helping patients while protecting healthcare workers.

CONCLUSIONS

Although many clinical laboratorians do not see or treat patients, they must be held accountable to the highest ethical and professional behavior. Recognition and understanding of ethical issues are essential to ethical practice of laboratory medicine.
Uke, flow and Rock‘n’Roll
Authors: Reese Jill Alyse
Published: August 2019

Community ukulele groups’ fertile contexts for participatory and amateur musicking are increasing in popularity. Though researchers have begun to describe contexts for community ukulele groups, more research is necessary to understand participants’ perceptions of their lived-experiences within the space of the jam sessions. Therefore, the purpose of this phenomenological case study is to describe the lived experiences of adults participating in a community ukulele group. Several research questions guided this study. First, what do they experience during jam sessions, and how do they describe their experiences? Second, how do these experiences relate to their sense of musical self? Third, what mechanisms impact their perceptions of their experiences? Three distinct but related ideas constitute the theoretical framework for this study: Turino’s concept of participatory performance, Csikszentmihaly’s flow theory, and Turner’s concept of communitas. Data were individual interviews and small-group re-enactment interviews with eleven community ukulele participants. The essence of the experience was that liminal space emerged in the context of the jam sessions and supported communitas that resulted in temporary transformation of identity and transcendence of concerns. This essence was supported by three themes: characteristics of liminal space, manifestations of communitas, and transformation and transcendence.
Exploring the meanings that stakeholders of the Brandfort community ascribe to their experiences of a Dalcroze-inspired workshop
Authors: van der Merwe Liesl , Tempelhoff Johann Wilhelm Nicolaas , Joubert Debra
Published: August 2019

For some time now, urban settlements in the rural areas of South Africa have experienced considerable problems relating to municipal water and sanitation service delivery. In September 2013, as part of a larger investigation in the town of Brandfort in the Free State Province, a transdisciplinary research team, Cultural Dynamics of Water (CuDyWat), conducted a workshop using Dalcroze-inspired activities based on music and movement to generate insight into local water-related problems. The objective was to come to an understanding of the lived experiences of a random group of community members and to contemplate potential solutions to the conundrum. This article reports on a novel application of Dalcroze, with non-musician participants, for the betterment of a social group in crisis. It is argued that Dalcroze-inspired activities are useful to encourage people to express themselves and gain better insight into the problems they face. This approach also serves to strengthen relationships in highly diverse groups.
By the People, for the People: Community Bookshops and Sustainable Business
Authors: Smith Hannah
Published: August 2019

This article analyses and discusses community bookshops as a viable commercial enterprise, by investigating the methods by which individual shops successfully balance a sustainable financial model with their prioritisation of social values. It uses secondary sources to conduct historical and contextual research, which is then synthesised with its primary research in the form of interviews and business model analysis. The article concludes that, by focusing on the needs of their local community, these bookshops are able to elevate the value of their business and products at a time when traditional retail outlets are struggling to retain customers. As beacons of social responsibility these businesses focus on collaboration and cohesion, along with developing the literacy of their local areas. Through their unique knowledge of their local community, and their community-ownership models, these bookshops display how economic function and social objectives can work hand in hand to create a sustainable and responsible business model.
Paulo Freire, seu legado com a dialética, educação popular e pol´ítica
Authors: Lorenzet Deloíze , Andreolla Felipe
Published: August 2019

Este artigo versa sobre a produção de Paulo Freire, renomado educador brasileiro, conhecido internacionalmente, cujo maior destaque foi sua atuação política na preocupação com a libertação humana. Para ele, a educação de modo primordial é a capacidade de tornar-se humano, ou seja, envolver-se no processo de humanização. Neste artigo, por meio de uma reflexão teórica, realizamos um resgate das concepções formuladas por ele acerca dos conceitos de dialética, educação popular e política. Didaticamente, três pontos conduzem essa reflexão: os aportes teóricos que fundamentaram a dialética em Freire; a concepção de educação popular desenvolvida por Freire; e, por fim, o entendimento de Freire e a articulação entre educação e política. Em linhas gerais, Freire acredita na educação como uma ferramenta de transformação social, no diálogo como um modo de construção da liberdade e emancipação.
Does managerial bias pose destructive impact on company? A non-linear relationship between CEO’s overconfidence and company value
Authors: Wiratama Bayu , Abiprayu Kris Brantas , Ridloah Siti
Published: August 2019

This research aims at testing the influence of CEO’s Overconfidence (KDB) on the values of companies registered with the Indonesian Stock Exchange in the period 2007-2015. KDB is a bias inherent in individual, particularly corporate CEO resulted from his/her great authority. A CEO with KDB will assume that his/her company has investment opportunities in the future and, thus, reduce dividend in anticipation of acquiring an investment opportunity in the future. Some opinions argue that KDB’s benefit will be maximal when the confidence is at moderate level. A manager is deemed able to contribute to his/her company, have a good innovation level, have optimal motivation level, and present lower level of cost of debt or capital and optimal amount and rate of investment return. Too low or too high KDB is deemed only to pose negative impact on company value as resulted from non-optimal degree of leverage and investment.
The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass graft surgery: a triple-blind clinical trial
Authors: Gholami Mohammad , Najafizadeh Hassan , Teimouri Hassan , Ardalan Arash , Pooria Ali , Tarrahi Mohammad Javad
Published: August 2019

Background

Fatigue is a common compliant among patients who undergo coronary artery bypass graft (CABG) surgery. This may affect patients’ function in all aspects. A few studies have already assessed the influence of complementary therapies on minimizing fatigue. This study aimed to investigate the combined effect of vitamin C and omega-3 polyunsaturated fatty acids (n-3 PUFA) on fatigue following CABG surgery.

Methods

In this randomized, triple-blind placebo-controlled trial, 160 patients who already underwent CABG surgery were randomly assigned into an experimental or a control groups. Each group consisted of 80 patients. The experimental group was given both n-3 PUFA and vitamin C the day before surgery. They also received the same supplements in the first 5 days of operation. The control group received only placebo. Subjects in both groups responded to Multidimensional Fatigue Inventory (MFI-20) scale in the beginning, and at the end of the intervention as well as on the fifth day of the operation. Chi-square test and independent t-test were used for data analysis.

Results

The mean fatigue score in experimental and control groups came up to 62.01 ± 4.06 and 67.92 ± 4.95 (p<0.0001), respectively, which was greater than that of the values we had before intervention. The mean difference of fatigue score was 3.97 ± 3.49 and 9.56 ± 6.41 (p<0.0001) prior and following the intervention, correspondingly.

Conclusion

Combination of vitamin C and n-3 PUFA effectively reduces post-operative fatigue among patients who undergo CABG surgery.
sine mugens nicht erdenken: wand ez kan vor in wenken rechte alsam ein schellec hase**: Women’s German Medieval-Arthurian Scholarship
Authors: Meyer Evelyn , Sterling-Hellenbrand Alexandra
Published: August 2019

This article offers a survey of German Medieval Studies as a discipline, focusing on three generations of women’s German Medieval-Arthurian scholarship. This scholarship demonstrates a breadth of discipline that might be perceived as unusual in contrast to Anglophone or Francophone Arthurian scholarship; this breadth is however characteristic of scholarship in German Medieval Studies. The authors analyse significant publications and female scholars within German Medieval Studies to shed a light on research areas, institutional developments as well as key figures that have emerged in German Arthurian scholarship over the last half-century. The authors conclude not only that the practice of truly interdisciplinary research has become a hallmark of today’s female scholarship, but also that new spaces have been created (and continue to emerge) for women to write, publish and teach in German Medieval-Arthurian scholarship.
Women’s Contributions to Middle English Arthurian Scholarship
Authors: Vishnuvajjala Usha
Published: August 2019

This article examines the history of scholarship of both Middle English Arthurian literature and its afterlives to argue that the marginalisation of such literature has slowly diminished – often through the work of women. The increasing numbers of women in academia coincided with the advent of new methodologies in literary studies in the late-twentieth century to produce a wide range of scholarship on English Arthurian literature, including on texts that had long been considered beneath serious study. This work continues now, with recent studies considering English Arthuriana through postcolonial theory, queer theory, affect theory, adaptation studies and many other methods.
Incongruent humour and pragmatic competence in the late-medievalManières de langage
Authors: Reed Emily
Published: August 2019

This article examines the acquisition of pragmatic competence in L2, applying this stimulating area of research to premodern texts in a way that has yet to be done (to the author’s knowledge). Specifically, this article discusses the teaching of “challenging” incongruent speech behaviours (such as sarcasm, banter, and irony) in a group of Anglo-Norman dialogues of the late Middle Ages. The present work focuses on the representation of incongruent speech acts in the dialogues, how this representation speaks to a pedagogical method that incorporated humour, and also the possible functions of humour in the pedagogical environment. The topic of incongruent performance and its pedagogical implications will also be considered. By discussing the depiction and role of incongruent speech behaviours in the dialogues, I argue that these texts were sophisticated teaching aides that may have used humour as a pedagogical tool to teach more difficult elements of language use.
POST-SCRIPT FROM FILM STUDIES: Whose choice? Watching non-English language films in the UK
Authors: Kirsch Griseldis
Published: August 2019

In a market dominated by Hollywood, it is easy to overlook that the number of films (and televised productions) which are not in English is actually by far greater than those in English. However, although some non-English language film industries are vast, only a comparatively small number of productions are screened outside of their country of origin. Therefore, before being translated and brought to screens for us to watch, already a filter applies, as the films are chosen by curators of film festivals or the industry. For that reason, films that are perhaps less representative but more interesting, or by a well-known director may be chosen over others that may have been more successful in their country of origin, but are made by a less-well know director or perceived to be less interesting for ‘foreign audiences’. The choice of what we watch is thus never entirely ours. Using Japan, Germany and the UK as example, I will offer some thoughts on what impact such a filter might have on the consumption, and therefore the perception, of a film outside of its country of origin and what challenges this poses for audiences and researchers.
Happily lost in translation: Misunderstandings in film dialogue
Authors: Desilla Louisa
Published: August 2019

This article examines the construal, cross-cultural relay and comprehension of misunderstandings by filmmakers, translators and audiences respectively of Bridget Jones’s Diary (2001) and Bridget Jones: The Edge of Reason (2004). It reports on findings of a case-study on implicatures in these two romantic comedies (Desilla 2009/2012/2014). Both genuine and feigned misunderstandings are found in the two films. Inter alia, the analysis will show that misunderstandings can serve comedic and/or narrative functions, the latter pertaining to both characterisation and, more crucially, plot advancement. It is also demonstrated how misunderstandings can permeate only a single layer or both layers of film communication.
X-Chromosome Insufficiency Alters Receptive Fields across the Human Early Visual Cortex
Authors: Green Tamar , Hosseini Hadi , Piccirilli Aaron , Ishak Alexandra , Grill-Spector Kalanit , Reiss Allan L.
Published: August 2019

Here, we investigated processing by receptive fields, a fundamental property of neurons in the visual system, using fMRI and population receptive field (pRF) mapping in 20 human females with monosomic Turner syndrome (TS) (mean age, 10.3 ± 2.0 years) versus 22 age- and sex-matched controls (mean age, 10.4 ± 1.9 years). TS, caused by X-chromosome haploinsufficiency in females, is associated with well-recognized effects on visuospatial processing, parieto-occipital cortical anatomy, and parietal lobe function. However, it is unknown whether these effects are related to altered brain structure and function in early visual areas (V1-V3) versus downstream parietal cortical regions. Results show that girls with TS have the following: (1) smaller volume of V1-V3, (2) lower average pRF eccentricity in early visual areas, and (3) sparser pRF coverage in the periphery of the visual field. Further, we examined whether the lower volume of early visual areas, defined using retinotopic mapping, in TS is due to smaller surface area or thinner cortex. Results show that girls with TS had a general reduction in surface area relative to controls in bilateral V1 and V2. Our data suggest the possibility that the smaller cortical surface area of early visual areas in girls with TS may be associated with a lower number of neurons, which in turn, leads to lesser coverage of the peripheral visual field compared to controls. These results indicate that X-chromosome haploinsufficiency associated with TS affects the functional neuroanatomy of early visual areas, and suggest that investigating pRFs in TS may shed insights into their atypical visuospatial processing.

SIGNIFICANCE STATEMENTTurner syndrome is caused by the absence of one of the two X-chromosomes in females. Using functional neuroimaging and population receptive field mapping, we find that chromosome dosage variation (X-monosomy) associated with Turner syndrome affects the functional neuroanatomy of the visual cortex. Specifically, girls with Turner syndrome have smaller early visual areas that provide lesser coverage of the peripheral visual field compared with healthy controls. Our observations provide compelling evidence that the X-chromosome affects not only parietal cortex, as described in previous studies, but also affects early visual areas. These findings suggest a paradigm change in understanding the effect of X-monosomy on the development of visuospatial abilities in humans.
Effects of the selective GPER1 agonist G1 on bone growth
Authors: Iravani Maryam , Lagerquist Marie K , Karimian Elham , Chagin Andrei S , Ohlsson Claes , Sävendahl Lars
Published: August 2019

Estrogens may affect bone growth locally or systemically via the known estrogen receptors ESR1, ESR2 and G protein-coupled estrogen receptor 1 (GPER1). Mouse and human growth plate chondrocytes have been demonstrated to express GPER1 and ablation of this receptor increased bone length in mice. Therefore, GPER1 is an attractive target for therapeutic modulation of bone growth, which has never been explored. To investigate the effects of activated GPER1 on the growth plate, we locally exposed mouse metatarsal bones to different concentrations of the selective GPER1 agonist G1 for 14 days ex vivo. The results showed that none of the concentrations of G1 had any direct effect on metatarsal bone growth when compared to control. To evaluate if GPER1 stimulation may systemically modulate bone growth, ovariectomized C57BL/6 mice were treated with G1 or β-estradiol (E2). Similarly, G1 did not influence tibia and femur growth in treated mice. As expected, E2 treatment suppressed bone growth in vivo. We conclude that ligand stimulation of GPER1 does not influence bone growth in mice.
Markers of systemic inflammation in response to osmotic stimulus in healthy volunteers
Authors: Sailer Clara Odilia , Wiedemann Sophia Julia , Strauss Konrad , Schnyder Ingeborg , Fenske Wiebke Kristin , Christ-Crain Mirjam
Published: August 2019

Osmotic stimulus or stress results in vasopressin release. Animal and human in vitro studies have shown that inflammatory parameters, such as interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), increase in parallel in the central nervous system and bronchial, corneal or intestinal epithelial cell lines in response to osmotic stimulus. Whether osmotic stimulus directly causes a systemic inflammatory response in humans is unknown. We therefore investigated the influence of osmotic stimulus on circulatory markers of systemic inflammation in healthy volunteers. In this prospective cohort study, 44 healthy volunteers underwent a standardized test protocol with an osmotic stimulus leading into the hyperosmotic/hypernatremic range (serum sodium ≥150 mmol/L) by hypertonic saline infusion. Copeptin – a marker indicating vasopressin activity – serum sodium and osmolality, plasma IL-8 and TNF-α were measured at baseline and directly after osmotic stimulus. Median (range) serum sodium increased from 141 mmol/L (136, 147) to 151 mmol/L (145, 154) (P < 0.01), serum osmolality increased from 295 mmol/L (281, 306) to 315 mmol/L (304, 325) (P < 0.01). Median (range) copeptin increased from 4.3 pg/L (1.1, 21.4) to 28.8 pg/L (19.9, 43.4) (P < 0.01). Median (range) IL-8 levels showed a trend to decrease from 0.79 pg/mL (0.37, 1.6) to 0.7 pg/mL (0.4, 1.9) (P < 0.09) and TNF-α levels decreased from 0.53 pg/mL (0.11, 1.1) to 0.45 pg/mL (0.12, 0.97) (P < 0.036). Contrary to data obtained in vitro, circulating proinflammatory cytokines tend to or decrease in human plasma after osmotic stimulus. In this study, osmotic stimulus does not increase circulating markers of systemic inflammation.
The Impact of Genomic and Traditional Selection on the Contribution of Mutational Variance to Long-Term Selection Response and Genetic Variance
Authors: Mulder Herman A , Lee Sang Hong , Clark Sam , Hayes Ben J , van der Werf Julius H J
Published: August 2019

De novo mutations (DNM) create new genetic variance and are an important driver for long-term selection response. We hypothesized that genomic selection exploits mutational variance less than traditional selection methods such as mass selection or selection on pedigree-based breeding values, because DNM in selection candidates are not captured when the selection candidates’ own phenotype is not used in genomic selection, DNM are not on SNP chips and DNM are not in linkage disequilibrium with the SNP on the chip. We tested this hypothesis with Monte Carlo simulation. From whole-genome sequence data, a subset of ∼300,000 variants was used that served as putative markers, quantitative trait loci or DNM. We simulated 20 generations with truncation selection based on breeding values from genomic best linear unbiased prediction without (GBLUP_no_OP) or with own phenotype (GBLUP_OP), pedigree-based BLUP without (BLUP_no_OP) or with own phenotype (BLUP_OP), or directly on phenotype. GBLUP_OP was the best strategy in exploiting mutational variance, while GBLUP_no_OP and BLUP_no_OP were the worst in exploiting mutational variance. The crucial element is that GBLUP_no_OP and BLUP_no_OP puts no selection pressure on DNM in selection candidates. Genetic variance decreased faster with GBLUP_no_OP and GBLUP_OP than with BLUP_no_OP, BLUP_OP or mass selection. The distribution of mutational effects, mutational variance, number of DNM per individual and nonadditivity had a large impact on mutational selection response and mutational genetic variance, but not on ranking of selection strategies. We advocate that more sustainable genomic selection strategies are required to optimize long-term selection response and to maintain genetic diversity.
Creatividad y desarrollo cognoscitivo (Un enfoque vigotskyano)
Authors: Badilla-Baltodano Beatriz
Published: August 2019

El desarrollo de la creatividad en las aulas universitarias es una necesidad en los tiempos actuales, donde los conocimientos teóricos son sólo una parte de la preparación que el futuro profesional debe tener. Los y las docentes deben considerar que la creatividad es algo que se puede fomentar y estimular en el acto educativo, por lo que tiene un importante papel que cumplir en este campo. En el presente trabajo, se hace el planteamiento del desarrollo de la creatividad basado en los esquemas establecidos por Vigotsky, Lev Semyónovich, quien con su aporte ha sentado las bases para desarrollar estas habilidades.
Cuentos viejos o diálogo con el universo
Authors: Rubio Torres Carlos Alberto
Published: August 2019

Cuentos viejos es un libro escrito por María Leal de Noguera, publicado en diferentes ediciones entre 1923 y 1945, que se puede considerar texto fundador de una literatura costarricense dirigida a las jóvenes generaciones. Constituye una colección de cuentos de hadas, que representan un caudal de conocimientos y sabiduría atesorados en muy diversas regiones del orbe. Para demostrar su vigencia, se hace un análisis de uno de los cuentos: “La mano peluda” y se descubre que este texto dialoga con mitos muy antiguos: la historia griega de Eros y Psique y una narración hindú del Panchatantra, en la cual se describe el amor de la ninfa Urvasi y el mortal Pururavas.
Los conocimientos previos en la alfabetización inicial
Authors: Flores Davis Luz Emilia
Published: August 2019

La alfabetización inicial constituye un reto para los sistemas educativos por su impacto en el desenvolvimiento de las personas en una sociedad letrada, así como por su importancia para el aprendizaje de las distintas disciplinas. En este ensayo, se presenta una reflexión sobre el papel de los conocimientos previos para generar aprendizajes significativos en el área de lectura y escritura, esta reflexión es posible a partir del análisis de información respecto a los procesos de construcción de la escritura realizados por niñas y niños de primer año de la Educación General Básica.
In vitro apoptosis induction ability of methanolic extract of Paramignya trimera root (Xao tam phan) in breast cancer stem cells
Authors: Nguyen Sinh Truong , Hung Le Van Manh , Mai Nguyen Thi Thanh , Nhan Nguyen Trung , Hai Nguyen Xuan , Phan Ngoc Kim , Dinh Kiet Truong , Pham Phuc Van
Published: August 2019

Objective: Cancer has been considered as one of the world's leading causes of death. Recently, the Paramignya trimera plant, locally called ``Xao Tam Phan'', has become a popular Vietnamese medicinal herb that is used as alternative medicine for cancer treatment support with minimal side effects. In this study, we aimed to demonstrate the cytotoxicity of methanolic extract of Paramignya trimera on a Vietnamese breast cancer stem cell line (VNBRCA1) in vitro.

Methods: We used the MTT assay to determine the cytotoxicity of the extract on VNBRCA1 cells and human fibroblast (HF) cell line was used as a control for the plant extract treatment. Clinically used anticancer drug, doxorubicin, was used as a control drug (for relative comparison to the plant extract) to evaluate the selective cytotoxicity of the plant extract on VNBRCA1 and HF cells. We examined the apoptosis induction by the plant extract on VNBRCA1by Annexin V/7AAD staining and flow cytometry analysis. In addition, the morphology of apoptotic nuclei of treated cells was observed by fluorescent microscopy using double fluorescent staining: Hoechst 33342 and propidium iodide (PI).

Results: In comparison between the cytotoxicity of the plant extract and Doxorubicin on both cell lines (VBRCA1 and HF), we observed that plant extract was selectively cytotoxic against VNBRCA1 with an IC50 value of 10610 μg/mL, while Doxorubicin was discriminatorily cytotoxic against HF with an IC50 value of 0.135+/-0.09 μg/mL. We also found that the plant extract induced apoptosis VNBRCA1 in a dose-dependent manner. In addition, fluorescent microscopy revealed disintegrated nuclei of plant extract-treated cells, representing a hallmark of apoptosis.

Conclusions: These results showed that Paramignya trimera methanolic extract selectively killed VNBRCA1 cell lines, indicating that Paramignya trimera methanolic extract may represent a potential agent for cancer treatment.
Extranjeros en Medellín. Motivaciones para su migración
Authors: Gómez Santa Gloria Mercedes , González Leivaz Daniela Liceth
Published: August 2019

El texto presenta resultados de la investigación Colombia como país receptor de Flujos Migratorios Laborales: Preparándonos para el presente. Se muestran características familiares de personas extranjeras residentes en Medellín y resultados acerca de la motivación que tuvo la migración desde el proyecto de vida individual y familiar de las personas entrevistadas. Se encuentra la presencia cada vez más activa de familias de inmigrantes en Medellín por razones laborales y se reconoce la importancia de las redes como soporte para la adaptación en el lugar de destino.
COMPARATIVE INVESTIGATION OF EGG PRODUCTION IN WG, GG AND GL JAPANESE QUAIL POPULATIONS
Authors: Lukanov H. , Genchev A. , Kolev P.
Published: August 2019

The aim of the study was to evaluate egg production in three heavy Japanese quail populations created and reared in the Poultry Breeding Unit of the Trakia University – Bulgaria, marked as WG, GG and GL. In the experiments, 160 female birds from populations WG and GG, and 96 female birds from population GL were tested up to the 6th production month. The main egg production traits were controlled. The highest egg production for the period was demonstrated in group GL (79.84±4.46%), followed by group GG (76.33±3.40%) and group WG (72.11±4.16%). Quails from the WG group were outlined with least efficient feed conversion per egg (74.49±1.21 g feed), while those from the GL group: with the most efficient one – 64.93±1.41 g (p<0.01). The highest average egg weight in descending order was observed in the WG group (14.04±0.32 g), GG group (13.65±0.27 g) and GL group (12.79±0.29 g). The Japanese quail populations created and maintained at the Trakia University showed a potentially good egg production for the production type they belonged to, which makes them attractive for use in interline hybridisation schedules, including for production of autosexing stock layers.
MODULATION ACTIVITY OF AYURVEDIC ANTIOXIDANTS AGAINST OCHRATOXIN (OTA) TOXICITY
Authors: Karamalakova Y. , Nikolova G.
Published: August 2019

People and animals are constantly exposed to the harmful effects of Ochratoxin A (OTA) induced– toxicity, by food. Despite the numerous scientific developments, the problems about damageable effect remain unsolved. The aim of this report is to evaluate and discuss the high protective and antioxidant properties of some Indian Ayurvedic plants (Curcuma longa, Tinospora Cordifolia and others) against OTA induced toxicity in blood and organs.
YIELD AND BOTANICAL COMPOSITION OF BIRD'S-FOOT-TREFOIL CULTIVARS IN TWO-COMPONENT MIXTURE WITH KENTHUCKY BLUEGRASS
Authors: Churkova B.
Published: August 2019

PURPOSE of the experiment is to study the influence of bird's-foot-trefoil cultivars of different origins over the productivity and quality of forage when they are grown together with Kenthucky bluegrass. METHODS: In the period of 2013-2015, in the experimental field of RIMSA-Troyan the productivity and botanical composition of bird's-foot-trefoil cultivars were studied, such as 'Targovishte 1', 'Delpon' (France), 'Fabio' (Italy), 'Haki' (Hungary), 'Vega' (USA) in two-component mixtures with Kenthucky bluegrass ('Sobra' cultivar).
RESULTS: The share of sown species and cultivars in the mixed grasslands of bird's-foot-trefoil and Kenthucky bluegrass depends on their biological characteristics, combined with the climatic and soil characteristics of the area. 'Fabio' cultivar shows the most pronounced adaptability to the soil climatic conditions of the region compared to all other bird's-foot-trefoil cultivar.
CONCLUSIONS: For the conditions of the Central Balkan Mountain, It is recommended to use the two-component mixture: bird's-foot-trefoil ('Delpon') and Kenthucky bluegrass ('Sobra'), which has the best intercompatibility and the most favourable combination of grass and legume component. The latter cultivar in the mixture recorded the highest average yields (650.37 kg/da dry weight) for the three-year study period, compared to other cultivars included in the experiment.
INFLUENCE OF THE VEGETATION PERIOD ON THE SPREAD OF ECONOMICALLY IMPORTANT VIRAL DISEASES IN BURLEY TOBACCO
Authors: Yonchev Y. , Keranova N.
Published: August 2019

The present study explores the influence of the vegetation period of Burley tobacco on the spread of viruses such as TMW, PVY-Complex, CMV / PVY-Complex, TSWV and CMV. To establish this relation, a correlation analysis is applied and the proven effects are represented by linear regression models. In 2014, the number of days from replanting has a strong positive impact on the percentage of plants infected by PVY-Complex (0.985**) as well as by TMV (0.781*). For 2015, the very strong effect was only seen on CMV / PVY-Complex (0.976**). In 2016, the duration of the period had a positive effect on the spread of CMV / PVY-Complex (0.868*), CMV (0.904 **) and TSWV (0.966**). In 2017 there is a very strong positive correlation between PVY-Complex (0.885*), CMV (0.948**) and TSWV (0.955**) on one hand and the planting period on the other. As a result of the conducted study over the entire four-year period, it has been proven that during the first two years the increase in the vegetation period leads to an increase in the incidence of PVY complex. During the second half of the analyzed period, CMV and TSWV are proved to be affected by the length of the time from the replanting.
Effect of Wingate-based high intensity interval training on aerobic and anaerobic performance of kick boxers
Authors: Akgül M.S.
Published: August 2019

Purpose: The aim of this study was to investigate the effects of two-week high intensity interval training (HIIT) on aerobic and anaerobic performance of kick boxers. Material: 24 male kick boxers (age 19.39 ± 0.72 y, body mass 74.14 ± 6.22 kg, height 177.95 ± 5.29 cm) volunteered for the study. Participants were randomly divided into two groups: experimental and control. As well as routine training program, experimental group carried out Wingate-based HIIT 3 times per week for two weeks. Wingate protocol was as follow: 4 repetitions with 4 mins recovery (4X30sn all-out effort) during the first week, 5 repetitions with 4 mins recovery (5X30sn all-out effort) during the second week. In order to determine aerobic capacity, 20m shuttle run test was used while Wingate anaerobic test was used to determine anaerobic performance. Descriptive statistic was used to demonstrate mean values and standard deviation of the variables. Non-parametric Mann Whitney-U test was used to show the differences between groups. Wilcoxon Signed Rank Test was used to compare intra-groups results from pre and post-test applications. Results: There was no significant difference between groups during pre-test measurements There was significant difference in PP, MP in experimental group compared to control during the post-test measurements. There was no difference in body mass, body fat (%) and predicted VO2max in both groups between measurements. Conclusions: According to intra and inter-group results, it can be concluded that two-week Wingate-based HIIT can be used to improve aerobic and anaerobic performances of kick boxers.
Role of sports activities in developing the important life skill of decision making; a psychological perspective
Authors: Khan Wasim , Khan Salahuddin , Arif Tasleem , Khan Sohail Roman
Published: August 2019

Purpose:It is generally believed that sports can play an important role in developing life skills and positive youth development. The purpose of this study was to determine the views of Gomal University students’ athletes on the role that sports played in developing the important life skill of decision making. The time management, planning, dealing with adversity and adapting new situation were taken as decision-making skills. Materials:A sample of n=375 (male=334, female=41 completed questionnaires. The researchers collected the required information with the help of self-administered structured questionnaire encompassing the selected variables of the study. The responses were tabulated and analyzed with the help of computer software. Results:The results showed participants attributed a significant role for sports in developing decision-making skills such as time management, planning, dealing with adversity and adapting new situation (603** at 0.01) and significant correlation between sports participation and the development of various decision-making skills among its participants (603** at 0.01). The results indicated that demographic characteristic such as gender, age, and level of sports participation of the athletes brings variations in the mean score of research variables (0.003, 0.004 & 0.001 < 0.05). conclusions:Results of the study indicated that sports provide an excellent opportunity for students to learn skills that can help them in taking positive as well as effective decision. The present exploration affirmed that students can acquire a) time management skill, b) proper planning, c) dealing with adversity, and d) the ability to adjust in a new situation through active participation in sports activities. However, some demographic characteristics of the sports participants such as gender, sports experience, and format of sports have an influence upon the development of these skills through sports.
The comparing of acute effects of two training models aerobic and resistance on the clotting times in young women students
Authors: Rahmani Ghobadi M. , Forghani Ozrudi M.
Published: August 2019

Purpose: Some of the benefits of physical activity may result from effects on hemostasis. However, the increased burden of cardiovascular complications and sudden death occurring during and immediately after exercise prompts investigation to elucidate the biological relationship between physical exercise and hemostatic function. The aim of this study was to determine effects of one bout exhaustive aerobic exercise and resistance training on the clotting times in healthy young women student. Material: Thirty trained volunteer female students of physical education were selected objectively and availability. The subjects were randomly divided into two groups of aerobic (n=15) and resistance training (n=15). Aerobic group performed exhaustive workout program on treadmill intensity 65 to75% VO2max on treadmill. The resistance group completed three sets of 5-7 repetitions of six exercises at an intensity corresponding to 80% of 1RM. Following 12 to 14 hours of nightly fasting, venous blood samples (5 cc) were collected pre, immediately after exercise and after 60 min of recovery and analyzed for PT (Prothrombin Time) and aPTT (Activated Partial Thromboplastin Time) times. Participants were matched according to anthropometric measurements, age and VO2max. Hypothesizes were tested by using independent t, repeated measures and post-hoc test (p≤0.05). Results: One bout of the exhaustive aerobic exercise and resistance training caused significantly shortening in PT (p<0.001) and aPTT (p=0.006, p<0.001 respectively) times at immediately after exercise. Also aPTT (p=0.005, p<0.001 respectively) times significantly increased after recovery in comparison with baseline levels in two groups. No significantly differences observed in PT and aPTT between two groups in all stages. The results show that exhaustive aerobic exercise and resistance training lead to mild and transit increase in coagulation system and induced shortening clotting times. Exercise-related hypercoagulability is mainly due to an increase in coagulation factor VIII (FVIII) with no parallel alterations of other clotting factors. Conclusions: Similar to endurance exercise, FVIII activity raises following resistance exercise, and appears to be positively correlated with the volume of weight lifted. The ß-adrenergic pathway has been implicated as a possible pathway mediating an exercise- induced increase in FVIII and decease clotting time.
Analysis of isokinetic knee strength in soccer players in terms of selected parameters
Authors: Yılmaz A.K. , Kabadayı M. , Bostancı Ö. , Özdal M. , Mayda M.H.
Published: August 2019

Purpose: The aim of study is to analyse isokinetic knee strength in soccer players in terms of selected parameters. Methods: A total of 30 subjects, 15 soccer players and 15 controls, were included in the study. Isokinetic knee strength measurements at angular speeds of 60°sec-1, 180°sec-1 and 240°sec-1 and pro-agility tests were conducted on the subjects. A body analyser was used for height, weight and body mass indexes (BMI) values. The training ages of the subjects and the positions of the soccer player group were recorded on personal information forms. Results: When the agility parameters were compared between football and control groups, a statistical difference was found in favour of the soccer player group (p < 0.05). When the effects of body composition and isokinetic knee strength on agility were analysed, negative significant correlation was found between weight and agility, BMI and agility and 240° right knee extension strength and agility (p < 0.05). When the positions of soccer players and isokinetic knee strengths were compared, significance was found between 60° right extension strength of defenders and midfielders and 60° left extension-flexion strengths of defenders and midfielders and forwards in favour of defenders (p > 0.05). Conclusions: In conclusion, it was found that isokinetic knee strength did not have an influence on agility in low angular speeds, except for 240°sec-1 right extension. According to positions, as the isokinetic knee strength of defenders decreased, they showed higher results when compared with other positions.
Factor's Influencing Contractors Risk Attitude in the Malaysian Construction Industry
Authors: Taofeeq D. M. , Adeleke A. Q.
Published: August 2019

The Malaysian construction industry often acts as a vehicle that motivates' the development of the nation's economy. The industry is commonly referred to as a catalyst for development. However, poor performance in terms of productivity and quality systems has been the main issues of discussion from most of the government reports. In order to improve performance in the Malaysian construction industry, the introduction of the Occupational Safety and Health Act (OSHA) in 1994 has made all industries in Malaysia to identify hazards, conduct risk assessment and control those risk and at the same time implement an integrated system to ensure consistency and better performance of projects in Malaysian industries. Therefore, in this paper, the ranking of specific factors affecting contractors' risk attitudes in the Malaysian construction industry was assessed. A review of relevant literature was undertaken to identify the factors influencing contractors' risk attitudes. The study found that the four leading specific factors influencing contractors risk attitude in the Malaysian construction industry are; Project Related Factors, Working capital, Human-Related Factors, and External Environment. The study confirms the individual factors that affect the contractor's risk attitudes. Knowledge of these factors will facilitate contractors' decision-making process and serve as a useful reference for further studies in the field of construction project management.

Keywords: Contractor's risk attitude, Malaysia, Risk attitude, Risk management
A State Legitimation Approach of Reserved Built Environment Professional Work - A Case for South Africa – Part 1
Authors: Manchidi T. E. , Rwelamila P. D.
Published: August 2019

This paper borrows from the lenses of the sociology of professions, sociology of science and temporary project organisations and construction reform to examine state legitimation of reserved built environment (BE) professional work as the first part of a two-part study. In doing so, it examines the growth of professions as a consequence of the division of expert labour evolving to fill in knowledge gaps created by emergent social forces as other knowledge areas are rendered less relevant. It shows how professional work negatively impacts on the delivery efficiencies in the project as a temporary organisation. In making this argument, it draws on the jurisdictional theory of professions to illustrate the relational and interactional relationship of professions in construction projects. To help focus on collaboration, a preliminary conceptual model for the legitimation of professions at the macro (policy) level is developed to explain how boundary margins keep professions relational, and how the dynamics of boundary work unfold in a territorial space in a project (meso) environment. Finally, it provides the scope of the second part of the study (the field study) by formulating the main research objective and research question and their respective specific research objectives and research questions, respectively.

Keywords: Built Environment Professions, Division of Expert Labour, Jurisdictional Boundaries, Legitimation, Professional Work, Temporary Organisations
Coordination of advocacy coalitions using cognitive maps
Authors: Melo Cristiano Santos Lúcio de , Vieira Diego Mota
Published: August 2019

Resumo Este artigo traz uma contribuição à análise de coalizões de defesa em processos de formulação ou mudança de políticas públicas, conjugando modelos de análise de políticas públicas e da pesquisa operacional (PO). Jenkins-Smith, Nohrstedt, Weible et al. (2014) observam, a partir dos resultados de algumas aplicações empíricas, que somente as crenças dos atores envolvidos não contam toda a história da mudança da política e ressaltam que o grau de conflito entre os atores ou as coalizões está relacionado às suas percepções quanto ao alcance das ameaças, dos objetivos ou das ações de outros atores, às suas crenças acerca de uma política. Diante do exposto, propõe-se uma abordagem para análise do grau de coordenação inter e intracoalizões políticas em processos de mudança institucional, a partir da identificação das crenças, dos objetivos declarados e das alternativas políticas dos atores, utilizando o pensamento focado no valor (value-focused thinking - VFT) associado aos mapas cognitivos causais. A partir da conjugação desses métodos, espera-se, por meio da comparação dos mapas cognitivos, identificar as coalizões políticas e caracterizar os ambientes colaborativos ou conflituosos, bem como identificar as agendas políticas com variados graus de cooperação ou conflito.