bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethanolic Extract Oitment of The Graptophylum Pictum L Griff Leaves as Analgesic agent to Male White Rat
Authors: Rikomah Setya Enti , Fitri Ninsi
Published: September 2022

Daun Graptophyllum pictum L. Griff dimasyarakat digunakan sebagai bahan obat, salah satunya untuk analgetik . Daun puding hitam mempunyai kandungan senyawa metabolit sekunder yang berperan sebagai analgetik diduga yaitu flavonoid. Ekstrak etanol daun puding hitam telah diformulasikan menjadi sediaan krim dan salep. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas analgetik sediaan salep ekstrak etanol daun puding hitam (Graptophyllum pictum L. Griff) pada mencit jantan putih. Efektifitas analgetik diuji menggunakan metode hotplate. Hewan uji yang digunakan sebanyak 25 ekor mencit jantan putih yang dibagi menjadi 5 kelompok yaitu kontrol negatif (F0), kontrol positif (salep Ichtiol®), dan kelompok perlakuan salep ekstrak etanol daun puding hitam F1 (10%), F2 (15%), dan F3 (20%). Pengamatan geliat mencit dilakukan setelah kaki mencit diinduksi dan langsung diberikan perlakuan. Pengamatan persentase analgetik pada masing-masing mencit dilakukan setiap 5 menit selama 60 menit. Data yang didapat diolah dan dianalisa menggunakan one-way anova dan uji duncan dengan tingkat kepercayaan 95%. Hasil uji one-way anova menunjukan terdapat perbedaan yang signifikan antar kelompok perlakuan (0,003<0,05). Hasil rata-rata persentase efektifitas analgetik formula 2 memberikan efek yang baik yaitu sebesar 77,969 %. Hasil uji duncanmenunjukan kelompok yang memberikan efektifitas analgetik terbaik adalah formula 2 (15%) sebanding dengan kontrol positif.
Analisis Kalsium (Ca) pada Ikan Petek dan Mujair dengan Metode Kompleksometri
Authors: Adriani Azmalina , Fauziah Fauziah , Saputra Riki
Published: September 2022

Ikan adalah salah satu contoh bahan pangan yang banyak mengandung protein dan mineralsalah satunya yaitu kalsium. Kalsium (Ca) berfungsi untuk metabolisme tubuh dalampembentukan tulang dan gigi. Ikan Petek dan Mujair mengandung kalsium yang dibutuhkanoleh tubuh manusia. Tujuan penelitian ini adalah untuk mengetahui kadar kalsium yangterkandung dalam ikan Petek dan Mujair. Pengambilan sampel dilakukan secara purposivesampling, dimana sampel yang digunakan diperoleh dari pasar Peunayong Banda Aceh.Penelitian dengan menggunakan metode kompleksometri. Sampel ikan Petek dan ikan Mujairyang telah di abukan dititrasi dengan menggunakan Na2-EDTA sebagai pentiternya. Hasilpenelitian dari ikan Petek dan Mujair memiliki kadar kalsium yang berbeda dimana kadarkalsium pada ikan Petek rata- rata mencapai 0,853 % dan kadar kalsium pada ikan Mujairrata-rata mencapai 0,616 % . Ikan Petek memiliki kadar kalsium lebih tinggi dari pada ikanMujair hal ini di sebabkan berdasarkan habitanya, dimana ikan Petek merupakan ikan air lautyang kaya akan lemak, vitamin, dan mineral, sedangkan ikan Mujair merupakan ikan airtawar yang banyak akan karbohidrat dan protein.
Identifikasi Tingkat Berpikir Kreatif Siswa Melalui Penyelesaian Masalah Matematika dengan Tipe Soal Open-Ended
Authors: Indriana Adelia Febby , Wijayanti Dyana , Ubaidah Nila
Published: September 2022

Jenis penelitian yang dilakukan adalah penelitian deskriptif kualitatif yang bertujuan untuk mendeskripsikan tingkat kemampuan berpikir kreatif matematis siswa kelas VII C SMP Negeri 1 Trangkil dalam menyelesaikan soal open ended materi aritmatika sosial. Pengambilan subyek dilakukan dengan menggunakan purposive sampling. Subyek penelitian meliputi 6 siswa kelas VII C SMP Negeri 1 Trangkil. Penelitian ini dilakukan dengan cara dokumentasi, tes tertulis dan wawancara. Analisis data dilakukan dengan reduksi data, penyajian data, serta penarikan kesimpulan dan verifikasi data. Berdasarkan hasil penelitian menunjukkan bahwa tingkat kemampuan berpikir kreatif siswa kelas VII C SMP Negeri 1 Trangkil sebagai berikut: (1) siswa dengan kemampuan matematis tinggi memiliki tingkat kemampuan berpikir yang sangat kreatif (TKBK 4) dalam menyelesaikan soal open ended; (2) siswa dengan kemampuan matematis sedang memiliki tingkat kemampuan berpikir yang kreatif (TKBK 3) dalam menyelesaikan soal open ended, dan; (3) siswa dengan kemampuan matematis rendah memiliki tingkat kemampuan berpikir yang kurang kreatif (TKBK 1) dalam menyelesaikan soal open ended. Dengan demikian, siswa perlu dibiasakan menyelesaikan masalah-masalah terbuka yang memiliki banyak cara penyelesaian dan jawaban benar yang beragam sehingga kemampuan berpikir kreatifnya dapat berkembang
The Role of 5' Adenosine Monophosphate-Activated Protein Kinase in the Chemo-Sensitivity and Metabolic Behaviour of Breast Cancer Cells Exposed to Hypoxia and Hyperglycaemia
Authors: Al Qahtani A. , Holly J.M.P. , Perks C.M.
Published: September 2022

Background: 5' adenosine monophosphate-activated protein kinase (AMPK) is a key enzyme for maintaining energy homeostasis in the cell and is associated with many downstream targets of metabolic processes such as mTORC1, p53 and fatty acid synthase (FASN) and insulin-like growth factor binding protein-2 (IGFBP-2).

Aim: To investigate the interactions between AMPK, FASN and IGFBP-2 and how the activity of AMPK affects the metabolism and response of breast cancer cells to chemotherapy with changes in oxygenation and under different glucose concentrations.

Methods: MCF-7 breast cancer cells were exposed to different glucose levels (5mM and 25mM) in the presence or absence of doxorubicin under normoxic and hypoxic conditions with and without AMPK silenced using siRNA. Changes in protein abundance were monitored using Western Immunoblotting. Cell death was measured by the Muse® Cell Analyser using a count and viability assay. Hypoxia was chemically induced using cobalt chloride or with low levels of oxygen (2%). Lactate and citrate levels were measured using commercially available kits.

Results: In normoxic conditions, AMPK activity was higher in normal levels of glucose (5mM) compared with high levels of glucose (25mM). Under hypoxic conditions, AMPK phosphorylation remained high in 5mM glucose with levels in 25 mM glucose being equivalent. Upregulation of AMPK in normoxic and hypoxic conditions was associated with a reduction in FASN and IGFBP-2, which resulted in a better response to chemotherapy. Moreover, the cells increased the production of lactate and reduced production of citrate under normoxic conditions in 25mM glucose compared to 5mM glucose. Silencing AMPK under normoxic conditions or inducing hypoxia promoted a more glycogenic phenotype. However, silencing AMPK under hypoxic conditions reduced levels of lactate comparable to normoxic levels. The citrate profile was unaffected by silencing AMPK or altering levels of oxygen.

Conclusions: AMPK plays an important role in regulating metabolic signalling and this alters the sensitivity of breast cancer cells to chemotherapy.
Kadın tüketicilerin satın alma davranışlarında reklam stratejilerinin etkisi
Authors: SOMTAŞ LEKESİZCAN Feyza , LEBLEBİCİ KOÇER Leyla
Published: September 2022

Kadın tüketicilerin gün geçtikçe daha bilgili ve finansal açıdan bağımsız hale gelmeleri işletmelerin pazarlama ve reklam stratejileri için önemli bir hedef kitle olmalarına da neden olmaktadır. Reklamların sürekli tekrar etmesi, markaların kendilerini bir ünlüyle özdeşleştirmesi, rakip ürünlerle reklamı yapılan ürünün mukayese edilerek tüketicinin etkilenmeye çalışılması, cinsel çekicilik unsurlarının reklamlarda kullanılması ya da çeşitli mizahi unsurların reklamlara dahil edilerek kadın tüketicilerin satın alma davranışlarına yönlendirilmesi ve tüm bu yöntemlerin etkili olup olmadığının araştırılması hem reklam verenler hem de tüketicilerin satın alma davranışlarının incelenmesi için önem arz etmektedir. Bu çalışma, reklamlarda kullanılan stratejilerin (tekrara maruz kalma, ünlü kullanımı, ürün kıyaslama, cinsel çekicilik, mizah kullanımı) kadın tüketicilerin satın alma davranışları üzerindeki etkisini ortaya çıkarmak amacıyla yapılmıştır. Bu bağlamda veri, kolayda örnekleme yoluyla seçilen 399 kadın tüketiciden nicel araştırma yöntemlerinden biri olan çevrimiçi anket yöntemiyle toplanmıştır ve veriler Yapısal Eşitlik Modeli ile analiz edilmiştir. Analiz sonuçlarında ünlü kullanımı, ürün kıyaslama, cinsel çekicilik, mizah kullanımı stratejilerinin kadın tüketicilerin satın alma davranışları üzerinde etkili olduğu ancak tekrara maruz kalma stratejisinin kadın tüketicilerin satın alma davranışını etkilemediği belirlenmiştir.
PERSONAL HOUSEHOLD PLOTS OF WORKERS AND EMPLOYEES OF SIBERIA IN THE 1930S: DYNAMICS AND DEVELOPMENT TRENDS
Authors:   Institute of History, Siberian Branch of the RAS, Ilyinykh Vladimir A.
Published: September 2022

Formation of a new model of agrarian system was the result of mass collectivization in the USSR. Collective farms were its organizational and production basis. The second largest sector of agriculture in terms of production potential consisted of personal household plots. They were main producers of potatoes, vegetables and milk, and a significant part of meat products. Soviet and Russian historiography has paid main attention to the study of the personal plots of collective farmers, overlooking the dynamics of personal plots of workers and employees. The author of the article reconstructs factors and trends of development of personal household plots of workers and employees in Siberia in the 1930s. It was found that in the early 1930s the size of personal plots of this category of population was minimal. State farm workers were prohibited from personal farming, and personal household plots of other categories of workers and employees were taxed at the rates of individual farmers. After the 1932–1933 mass famine, several restrictions on the development of personal household plots were canceled. Level of its taxation was decreased. Liberalization of state policy and an increasing part of workers and employees in population of the region led to a rapid growth in production potential of their personal plots. Development rate of workers and employees’ personal plots was higher than that of collective farmers. In the late 1930s a campaign took place to limit the size of personal household plots. Taxation was increased. This led to decline in the personal sector of agricultural economy.
ANTI-PARTISAN PROPAGANDA OF THE GERMAN AUTHORITIES IN THE OCCUPIED SOVIET BELARUS TERRITORY
Authors:   Russian Customs Academy, Pushkarenko Elena A.
Published: September 2022

The article examines the ideological aspects of the German struggle against partisans in the occupied territory of Soviet Belarus. The author, on the basis of previously unpublished documents of the National Archives of the Republic of Belarus (propaganda publications of the occupation authorities, orders and circulars of the heads of the German General Commissariat, reports of partisans) and a number of historical studies, analyzes the content of German propaganda materials, identifies its main thematic areas, determines the effectiveness of anti-partisan propaganda. The heads of the General District (W. Kube and C. von Gottberg) expressed a special opinion on the methods of anti-partisan struggle. They believed that punitive actions were ineffective and the main stake in the anti-guerilla struggle made on propaganda and involvement of the local population. The author concludes that the massive and large-scale propaganda influence of the German administration was neutralized by an extremely cruel occupation policy (namely, punitive actions of the SS against partisans and the civilian population living in the partisan zone, the genocide of Jews, which caused obvious rejection and fear) as well as partisan counter-propaganda. Attempts to involve the Belarusian population to combating partisans proved to be not very effective. Moreover, the very actions of the German occupation authorities — forced recruitment to work in Germany, as part of numerous collaborationist organizations — forced Belarusians to seek salvation among the partisans.
BRITISH RESEARCHER OF RUSSIAN HISTORY: THE SCIENTIFIC LEGACY OF PROFESSOR PAUL DUKES
Authors:   Northern (Arctic) Federal University named after M. V. Lomonosov, Goldin Vladislav I. , Alekseeva Elena V. ,   Institute of History and Archaeology, Ural Вranch of the RAS
Published: September 2022

The article is devoted to the representation of the scientific legacy of Paul Dukes (1934–2021) — a member of the Royal Society of Edinburgh, Professor of the University of Aberdeen, a prominent British historian, whose study focused on relations between Russia and the West. Based on the analysis of his works, the authors define the scope of his research interests and provide their characteristics. They present some results of his understanding of the key problems of Russian history, the place and role of our country in Europe and in the world. His books on the history of the Russian Empire, the relationship between Russia and Europe, Russia and the United States, and the problems of the Russian revolutions at the beginning of the 20th century are marked as milestones in the evolution on the research path of a professional historian. The theme of Russia’s revolutions, the assessment of the global legacy of the 1917 Russian Revolution in a comparative perspective, was one of the main subjects in the scientific work of Professor P. Dukes. The conviction in the need for a comparative approach to the study of revolutions was reflected in his analysis of revolutions and reforms in Russia in a global context. It is emphasized that P. Dukes was interested in the role of personality in history in various aspects: in the context of Russia’s international relations (for example, relations between the Stuarts and the Romanovs), the revolutionary movement (leaders of the Russian revolutionary process), in war conditions (the relations between the leaders of the Big Three in the years of the Second World war). Particular attention is paid to the development of P. Dukes’ interest in the Russian regions, fruitful contacts with Ural historians, and his priority in creating a monograph on the history of the Urals in English. The significance of the historian’s addressing to the topic of the Anthropocene is also noted.
CHANGES OF TEMPORAL REGIMES AND CONTRADICTORY IMAGES OF THE NATIONAL
Authors:   Institute of World History of the RAS, Ionov Igor N.
Published: September 2022

The article describes the phenomenon of interference of different cultural practices broadcast in space and time: temporal regimes, images of time as a sphere of possible stories at a given period, and images associated with national self-consciousness and nationalism. The measure of the connection is analyzed between the progressive change in the perception of time described by R. Koselleck, when expectations are separated from experience, and the formation of national self-consciousness at the end of the 18th–19th centuries, as well as between the post-progressive transition from “solid” to “liquid” time described by Z. Bauman and the transformation of national identity into diverse forms of collective self-identifications, self-understandings and identity politics at the end of the 20th−21st centuries. The role in these processes of the transforming attitude to the time of the embodiment of the meaning of history ( airos) is considered: from the unchanging, general and exclusive, associated with the life path of Christ and the idea of the Second Coming, to the changing, multiple and exclusive (the progress of civilization in a given country as airos) and beyond, in the conditions of relativization of the “civilization” concept — to interacting inclusive senses of time, multi-temporality of connected histories or histoire croisée corresponding to multi-level ways of self-identification of the population (synaxis or co-existence, conciliar time). It is these temporal structures that create the prerequisites, first for the creation and strengthening of national self-consciousness, and then for its erosion.
TRANSDISCIPLINARITY IN THE STUDY OF SOCIOCULTURAL PRACTICES OF EVERYDAY LIFE (ON THE EXAMPLE OF THE PHENOMENON OF FAMINE IN VICTORIAN ENGLAND)
Authors:   Institute of World History of the RAS, Repina Lorina P. , Shabunina Anastasia K. ,   Institute of World History of the RAS
Published: September 2022

The study of the role of sociocultural practices in the everyday life of society involves the synthesis of methodological approaches in order to create a transdisciplinary research model. Analysis of various aspects of private life in the context of studying socio-cultural practices requires an analysis of the value categories of the society under study, taking account of worldview interpretations of phenomena by contemporaries, cultural attraction, individual self-identification and psychological perception of ongoing processes. The phenomenon of the Victorian famine is not meant to be studied only as a strictly biological phenomenon. The article interprets hunger as a sociocultural phenomenon, considers the associated fear of social stigmatization. The famine in the early Victorian period acts as a factor in the conceptual context of ongoing social phenomena, influencing the reception of cultural ties within society. The categories of “food”, “hunger” and “starvation death” were everyday companions of the public discourse of the era, reflecting the crisis state of Victorian society. Not only was the famine a factor that increased the potential for conflict, as it was perceived in the middle of the century, but by the end of the 19th century it began to be recognized by the authorities as a consequence of social contradictions and acted as an argument for the introduction and continuation of legislatively supported forms of social compromise. Having reworked the inhumane concept of getting rid of “social surpluses” of the period of popularity of Malthusian philosophy in the Middle Victorian period, the Victorians change the topology of the “hunger” concept in the system of structural and semantic models of social dialogue. The sociocultural phenomenon of famine is transformed in the communicative space of the Victorian era from a marker of condemned poverty into a social problem that unites various social groups.
THE CONCEPT OF “REPUBLIC” IN PUBLIC SPACE OF THE RUSSIAN EMPIRE OF THE FIRST QUARTER OF THE 19TH CENTURY
Authors:   Institute of History and Archaeology, Ural Branch of the RAS, Timofeev Dmitry V.
Published: September 2022

On the basis of the comparative and contextual analysis of publications in the Russian periodicals of the first quarter of the 19th century the article reconstructs the methods of argumentation used in the course of public discussion of ideals and practice of republicanism. Theoretical approaches of the modern history of concepts are used as methodological tools to reveal the ideas of contemporaries about the essence of the republic, the reasons for its emergence and decline, the nature of the relationship between citizens and the state. The intellectual context of Russia’s republican discourse was built on the basis of combination of two space-time prospects — historical experience of the republics of the ancient world and the description of options of the embodiment of the republican idea in France, the modern small states, and “the Republic of the Connected American Areas”. In public space of Russia of the first quarter of the 19th century the republicanism remained an important element of a discourse “about the best form of communal life” which starting point was a statement about the paramount importance of moral qualities of subjects/citizens and the monarch for steady functioning of power institutes. Such interpretation of the republican idea in Russia caused a shift from a question of the institutional embodiment of the republic to reflections about a possibility of combination of republicanism as the ideas of joint action of patriotic citizens, their partnership in “common cause” with historically developed monarchic form of government.
Displaying Dissent: On Faith, Consumerism, and Censorial Discipline in the Israeli Museum
Authors: Gal Nissim , Milano Ronit
Published: September 2022

An unusual violent clash between religious, Christian and Muslim demonstrators and the Haifa Museum of Art took place on Thursday, January 9, 2019. The protesters amassed the entrance of the museum to express their distress against the exhibition Shop It! A handheld firebomb thrown towards the museum was but the first round for the violent reactions of the next several days. These included attacking police forces and attempts to break into the museum featuring works of art considered sacrilegious by the demonstrators. The protest developed into a multi-participant debate in the art scene, involving ordinary citizens, artists and art curators, local church leaders, the city mayor, the minister of culture and other politicians, civil rights organizations and the court, as each part sought to exercise civic, moral, ethical or practical authority to censor the position or the work of the other. The article seeks to analyze the different ways in which mechanisms of regularization, supervision and punishment, which have always been part of the world of art, are used not only by those perceived as apparatuses of the state or as ideological mechanisms of abstract political or institutional entity, but as standard practices in the discourse of creating, trading, curating and presenting art – a discourse which, in the Israeli-Palestinian context, is imbued with the notion of national conflict.
STUCTURAL EQUATION MODELING-PARTIAL LEAST SQUARE-UNTUK PERMODELAN PENGARUH KOMPETENSI KEWIRAUSAHAAN TERHADAP KINERJA USAHA KEDAI KOPI SKALA KECIL DI KOTA PADANG
Authors: Paloma Cindy , Yusmarni Yusmarni , Putri Afrianingsih , Hasnah Hasnah
Published: September 2022

During the COVID-19 pandemic, the growth of small-scale coffee shops has increased in Padang city. This condition indicates the high level of coffee consumption and the increased competition of coffee shops. A good entrepreneurship competency is needed to improve business performance. This research aims to analyze the influence of entrepreneurial competency on small-scale coffee shop business performance in Padang City. This research used an Entrepreneurial competency model influenced by psychological characteristics (indicated by motivation, achievement, socialize need) and environmental factors (characterized by social net, government policy, and supply). The business performance model is influenced by entrepreneurial competency (managerial skill, conceptual skill, social skill, decision-making skill, and time managerial skill)  and environmental factors. This research used a snowball sampling method of 100 data samples of small-scale coffee shops (owner and barista) in Padang City from April until May 2021. The data was then analyzed by SEM-PLS analysis with SMART PLS 3.3 software. The result showed that psychological characteristics and environmental factors influenced the entrepreneurial competency in small-scale coffee shops. The business performance was influenced by entrepreneurial competency and environmental factors in the small-scale model. The results also show that the model was used in this research has a Model Fit of 84%.
AN ANALYTIC STUDY OF INSTITUTIONAL DEVELOPMENT MODEL OF SHALLOT AGRIBUSINESS FARMERS IN RUMBIA DISTRICT, JENEPONTO REGENCY
Authors: Asriadi Andi Amran , Husain Nailah , Hasriani
Published: September 2022

The objectives of this study were to identify the various types of farmer agribusiness institutions and to investigate the factors that influenced shallot farmers' group institutional growth in Rumbia District, Jeneponto Regency. Simple random sampling was defined as a sampling technique of every item in the population. The study was conducted out by utilizing a field interview technique with onion commodity questionnaires from farmers, collectors, suppliers, and merchants. The study's findings demonstrated that the diversity of marketing forums used by farmers participating in distribution had two channels: first (producers, collectors, traders, consumers) and second (producers, collectors, traders and consumers) (producers, collectors, inter-district wholesalers, district traders and consumers). The farmer group (X1) had a very significant effect on the growth of farmer institutions as a farmer's economic institution using a significant effect coefficient of 0.331 (p 0.001), then the beta coefficient was significant and the direction was positive. This a coefficient was influence of 0.205 (p>0.005), so that the association of farmer groups (X2) had no effect.
PENGARUH EXSPOR IMPOR INFLASI DAN FDI TERHADAP PRODUK DOMESTIC BRUTO ATAU PDB DI RUSIA DAN AMERIKA PERIODE
Authors: Hayatunnisa Syaufi
Published: September 2022

Makalah ini bertujuan untuk menganalisis dan menjelaskan: pengaruh inflasi, ekspor, impor, FDI terhadap PDB di Amerika dan Rusia periode 2010-2020, makalah ini menggunakan data sekunder yang diambi di World Bank Data dan menggunakan metode penelitian uji asumsi klasik dan regresi linier berganda dalam program SPSS untuk mengetahui variabel yang diambil normalitas atau tidak. Hasil dari uji tersebut dikatakan tidak normalitas karena titik titik tidak berada di anatara garis diagonal pada Negara Rusia sedangkan dikatakan normalitas karena titik titik berada di anatara garis diagonal pada Negara USA.
Differential expression of MYCN in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: September 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of MYCN, encoding v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, in primary motor neurons of patients with ALS. MYCN was also differentially expressed in the fibroblasts isolated from patients with ALS. MYCN transcript was present at significantly lower levels in ALS patient fibroblasts as compared to control, non-diseased fibroblasts. These analyses will begin to define the transcriptional landscape of ALS.
Using Digital Trace Data to Monitor Human Mobility and Support Rapid Humanitarian Responses
Authors: Rowe Francisco
Published: September 2022

Global warming is increasing the frequency of extreme weather events leading to an increased risk of large-scale population displacements. Since June 2022, Pakistan has recorded destructive flash flooding resulting from melting glaciers and torrential monsoon rainfall. Emergency responses have documented flood-related deaths, injuries and infrastructure, less is known about population displacements resulting from recent floods. Information on these populations and mobility is critical to ensure the appropriate delivery of humanitarian assistance where it is most needed. Lack of granular spatial data in real time have been a key barrier. This article uses digital footprint data from Meta-Facebook to identify the patterns of population displacement in Pakistan in near real time.
DASAR PEMIKIRAN MONETER DALAM SISTEM KEUANGAN ISLAM
Authors: T Andi Marhuni
Published: September 2022

Cara untuk mengatasi ini,menurut islam adalah dengan memproduktifkan uang, menyalurkannya sesuai kebutuhan, atau diarahkan ke jangka Panjang atau dalam hal ini Investasi.
PENGARUH INFLASI EKSPOR IMPOR TERHADAP PDB DI OMAN DAN UNITED ARAB EMIRITES PERIODE 2011-2021
Authors: Zamzam Arfiani Nur
Published: September 2022

Perkembangan perekonomian suatu negara saat ini tidak dapat terlepas dari kondisi perekonomian global. Hubungan ekonomi antara negara dengan negara lain menjadikan faktor penting yang mempengaruhi terhadap perkembangan ekonomi masing-masing. Penelitian ini bertujuan untuk menganalisis dan menjelaskan: (1) pengaruh inflasi terhadap PDB di Oman dan United Arab Emirites tahun 2011-2021, (2) pengaruh ekspor terhadap PDB di Oman dan United Arab Emirites tahun 2011-2021, (3) pengaruh impor terhadap PDB di Oman dan United tahun 2011-2022, Dengan menggunakan jenis metode kuantiitatif. Data tersebut dan dapat diketahui bahwasanya angka Berdasarkan Uji-F diketahui bahwasannya nilai Signifikansi terhadap negara Oman 0,001 > 0,05, Dan nilai Signifikansi terhadap negara United Arab Emirates 0,074 > 0,05, Dengan demikian menunjukkan bahwa proporsi Investasi Asing Langsung, Inflasi, Ekspor, dan Impor Tidak Berpengaruh Terhadap PDB.
Sharp reductions in COVID-19 case fatalities and excess deaths in Peru in close time conjunction, state-by-state, with ivermectin treatments
Authors: Chamie-Quintero Juan , Hibberd Jennifer , Scheim David
Published: September 2022

On May 8, 2020, Peru’s Ministry of Health approved ivermectin (IVM) for the treatment of COVID-19. A drug of Nobel Prize-honored distinction, IVM has been safely distributed in 3.7 billion doses worldwide since 1987. It has exhibited major, statistically significant reductions in case mortality and severity in 11 clinical trials for COVID-19, three with randomized controls. The indicated biological mechanism of IVM is the same as that of antiviral antibodies generated by vaccines—binding to SARS-CoV-2 viral spike protein, blocking viral attachment to host cells.Mass distributions of IVM for COVID-19 treatments, inpatient and outpatient, were conducted in different timeframes with local autonomy in the 25 states (departamentos) of Peru. These treatments were conducted early in the pandemic’s first wave in 24 states, in some cases beginning even a few weeks before the May 8 national authorization, but delayed four months in Lima. Analysis was performed using Peruvian public health data for all-cause deaths and for COVID-19 case fatalities, as independently tracked for ages 60 and above. These daily figures were retrieved and analyzed by state. Case incidence data were not analyzed due to variations in testing methods and other confounding factors. These clinical data associated with IVM treatments beginning in different time periods, April through August 2020, in each of 25 Peruvian states, spanning an area equivalent to that from Denmark to Italy and Greece in Europe or from north to south along the US, with a total population of 33 million, provided a rich source for analysis.For the 24 states with early IVM treatment (and Lima), excess deaths dropped 59% (25%) at +30 days and 75% (25%) at +45 days after day of peak deaths. Case fatalities likewise dropped sharply in all states but Lima, yet six indices of Google-tracked community mobility rose over the same period. For nine states having mass distributions of IVM in a short timeframe through a national program, Mega-Operación Tayta (MOT), excess deaths at +30 days dropped by a population-weighted mean of 74%, each drop beginning within 11 day after MOT start. Extraneous causes of mortality reductions were ruled out. These sharp major reductions in COVID-19 mortality following IVM treatment thus occurred in each of Peru’s states, with such especially sharp reductions in close time conjunction with IVM treatments in each of the nine states of operation MOT. Its safety well established even at high doses, IVM is a compelling option for immediate, large scale national deployments as an interim measure and complement to pandemic control through vaccinations.
PENGARUH INFLASI,EKSPOR DAN IMPOR TERHADAP PDB DI CHINA DAN INDIA PERIODE 2012-2021
Authors: awahah layina
Published: September 2022

Pertumbuhan ekonomi merupakan proses peruahan dengan kondisi perekonomian di dalam suatu negara secara terus-menerus menuju pada keadaan yang lebih baik selama dalam periode tertentu.Dalam perdagangan internasional sumber daya langka merupakan salah satu untuk menyempurnakan kebutuhan manusia.Maka terjadinya persaingan perdagangan yang semakin ketat,sehingga perwilayahan ekonomi global yang melanda dunia akan mempengaruhi tatanan perekonomian negara-negara serta tatanan ekonomi dunia.Dua negara Asia memiliki penduduk miskin terbesar yaitu,india dan china keduanya hadir menjadi pusat ekonomi ,politik,dan budaya yang kuat.Perekonomian india dan china tumbuh pesat berkat liberalisasi pasar,ketepatan pilihan industrialisasi dan kepimpinan yang baik.Penelitian ini bertujuan untuk menganalisis dan menjelaskan:(1)Pengaruh inflasi terhadap PDB di China pada tahun 2012-2021,(2) Pengaruh ekspor terhadap PDB di China pada tahun 2012-2021,(3) Pengaruh impor terhadap PDB di China pada tahun 2012-2021,(4) Pengaruh inflasi terhadap PDB di India pada tahun 2012-2021,(5) Pengaruh ekspor terhadap PDB di India pada tahun 2012-2021,(6) Pengaruh impor terhadap PDB di pada tahun 2012-2021.Penelitian ini menggunakan data kuantitatif menggunakan metode regresi linear berganda.Hasil penilitan menunjukan bahwa uji t di negara China dan India menunjukan tidak mempengaruhi GDP,sedangkan uji f di negara China dan India dapat mempengaruhi GDP.
Differential expression of STC1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: September 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published and public data (3, 4). We found significant differential expression of STC1, encoding stanniocalcin 1, in the motor neurons of patients with ALS. STC1 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. STC1 transcript was present at significantly higher levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Pengaruh Expor, Import, Dan Kurs Terhadap GDP Di Brunei Darussalam Dan Malaysia Periode 2012-2022
Authors: Fajriati Isma Fathya
Published: September 2022

Penelitian ini dimaksudkan untuk mengetahui apakah terdapat pengaruh yang signifikan antara tingkat eksor, tingkat impor dan kurs terhadap GDP di negara Brunei Darussalam dan Malaysia pada tahun 2012-2020. Dalam penelitian ini peneliti menggunakan penelitian kuantitatif deskriptif dengan menjelaskan nilai expor, impor, dan kurs berpengaruh terhadap GDP negara Malaysia dan Brunei Darussalam yang dilakukan penacarian angka dengan uji penelitian sekunder melalui spss. Teknik analisis dalam penelitian ini menggunakan teknik analisis Uji asumsi klasik, Uji normalitas, uji multikoleniaritas, uji regresi linier berganda dengan uji t dan uji f. Hasil analisis data menunjukkan perbedaan antara impor, expor, dan kurs terhadap GDP di negara Brunei Darussalam dan Malaysia periode 2012-2020, dengan distirbusi uji normalitas dikatakan normal, sedangkan Brunei Darussalam dengan distribusi uji normalitas dikatakan tidak normal. Menunjukan impor, ekspor, dan kurs terhadap GDP Brunei Darussalam tidak signifikan dengan hasil uji sedangkan Malaysia signifikan dengan hasil uji. Namun, dalam uji regresi linier berganda dengan uji t dan uji f menunjukkan bahwa expor, impor, dan kurs negara Brunei Darussalam dan Malaysia tidak berpengaruh terhadap GDP negara tersebut.
Will axolotls show us the secret of brain regeneration?
Authors: Mindsponge AISDL
Published: September 2022

Humans have a very limited capacity to regenerate lost body parts compared to salamanders. The “Internet’s favorite” cute axolotls are actually amazing creatures in terms of regeneration ability. An axolotl is able to regenerate its damaged limbs, heart, spinal cord, and even brain and thus rarely has age-related diseases.
Old age and wisdom
Authors: Mindsponge AISDL
Published: September 2022

Wise old man under the banyan tree, does the wisdom come from his age or the man himself?Wisdom is very elusive, so seeking wisdom is not easy. It is common among laypeople that wisdom comes with age, but is it right?
DASAR PEMIKIRAN MONETER DALAM SISTEM KEUANGAN ISLAM”
Authors: Muh.Hizbullah
Published: September 2022

Terciptanya stabilitas permintaan uang dan mengarahkannya pada tujuan yang penting dan produktif
Dasar Pemikiran Moneter dalam Sistem Keuangan Islam
Authors: Akbar Muh.
Published: September 2022

Konsep ini mengandung dua unsur pengertian. (a) suatu bentuk keseimbangan dan perbandingan antara orang yang memiliki hak. (b) hak seseorang hendaklah diberikan dan diserahkan dengan seksama. Stabilitas nilai uang
PENGARUH EKSPOR, IMPOR, DAN KURS TERHADAP PDB DI INDONESIA DAN FILIPINA PERIODE 2010-2020
Authors: Rahmah Listya
Published: September 2022

Penelitian ini bertujuan untuk menganalisis: 1) Pengaruh ekspor, impor, dan kurs terhadap PDB di Indonesia tahun 2010-2020, 2) Pengaruh ekspor, impor, dan kurs terhadap PDB di Filipina tahun 2010-2020. Penelitian ini menggunakan metode kuantitatif. Era global saat ini mendorong semua negara ke dunia perdagangan internasional. Salah satu alat dan sumber pembiayaan yang sangat penting dalam perdagangan internasional adalah Produk Domestik Bruto. Produk Domestik Bruto atau yang biasa dikenal dalam istilah bahasa Inggris Gross Domestic Product adalah jumlah produksi baik itu barang atau jasa yang sudah dihasilkan oleh unit produksi di suatu daerah pada waktu tertentu. Diambil dari situs resmi Badan Pusat Statistik, GDP menjadi salah satu indikator penting untuk mengetahui kondisi ekonomi di suatu negara dalam suatu periode tertentu. GDP bisa dijadikan sebagai indikator ekonomi suatu negara untuk mengukur jumlah total nilai produksi dimana jumlah tersebut dihasilkan oleh semua orang maupun perusahaan baik yang dimiliki lokal maupun asing di suatu negara. Selain itu ekspor dan impor sangat berpengaruh terhadap perekonomian suatu negara.
Treatment Maksiat Menurut Ibnu Qayyim Al-Jauziyah
Authors: Lubis Sarah Kurnia Dewi
Published: September 2022

Manusia tak lepas dari suatu kesalahan yang menjadi dosa, dari dosa kecil dan besar , dosa yang disengaja dan tidak di sengaja, dosa lahir dan dosa batin, dan dosa yang tampak dan tidak nampak. Oleh karena itu, kita sebagai manusia yang diberi akal untuk berpikir dan kesadaran menjadi suatu keingan kembali pada untuk dekat dengan Sang Maha Pencipta. Dalam kehidupan di dunia yang tidak kekal ini, sering kita melakukan hal-hal yang melanggar aturan Allah SWT dalam artian larangan-larangannya. Yang mana semua larangan-larangan-Nya itu merupakan suatu hal yang bersifat kenikmatan sementara yang pada akhirnya menimbulkan kesengsaraan atau kecelakaan bagi pelakunya. Tidak seorang pun di dunia ini menghendaki kecelakaan atas dirinya, pada umumnya mereka menghendaki keselamatan baik pada saat mereka berada di dunia yang menghendaki kecelakaan atas dirinya. Pada umumnya mereka menghendaki keselamatan baik pada saat mereka berada di dunia maupun di akhirat kelak. Masalah dalam penelitian ini adalah bagaimana pendapat Ibnu Qayyim Al-Jauziyyah terhadap maksiat? Tujuan penelitian ini adalah untuk menjelaskan bagaimana konsep maksiat menurut pendapat Ibnu Qayyim Al-Jauziyyah. Penelitian ini menggunakan metode library research. Untuk itu dalam pengumpulan data penulis menggunakan metode dokumentasi. Sementara dalam Metode Analisis Data peneliti melakukan Analisis isi untuk menggali keaslian teks lalu Analisis Deskriptif untuk menggambarkan keadaan subyek penelitian berdasarkan fakta. Kesimpulan dalam penelitian ini yaitu bahwa taubat menurut Ibnu Qayyim Al-Jauziyyah adalah suatu usaha dari beberapa pekerjaan hati. Singkatnya, menurut para ulama, taubat itu ialah membersihkan hati dari dosa. Ibnu Qayyim Al-Jauziyyah menekankan bahwa, para pelaku maksiat diharuskan untuk bertaubat karena dua hal: Pertama, agar berhasil memperoleh pertolongan guna mencapai ketaatan, karena berbagai perbuatan dosa dapat melahirkan kesialan dan mengakibatkan kemalangan bagi pelakunya. Selain itu, perbuatan dosa juga bisa menghambat upaya kita untuk mematuhi dan mengabdi kepada Allah Swt.
It is time to rethink, redefine and reform (neoclassical) economics
Authors: Khuc Quy Van
Published: September 2022

It is time to rethink, redefine and reform (neoclassical) economics
Effect of race on Gaze Cueing in adults with high and low autistic traits
Authors: Ricciardelli Paola , Pintori Noemi
Published: September 2022

In an online study we investigated in White Italian adults whether individuals with high autistic traits (measured by the Autism spectrum Quotient) show reduced implicit racial bias (measured by the Implicit Association Test) and if this bias would lead to differences in the gaze cueing effect (GCE) triggered by gaze direction of faces of different races. Results showed that participants with high and low-medium autistic traits had the same ingroup bias. Interestingly, females with high autistic traits showed a significant GCE only for White faces. However, with Black cueing faces when the AQ score increased the GCE decreased or was absent. In females, higher level of autistic traits is associated with a reduced ability to orient attention toward the outgroup.
Differential expression of IZUMO2 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: September 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of IZUMO2, encoding IZUMO family member 2, in primary motor neurons of patients with ALS. IZUMO2 was also differentially expressed in the fibroblasts isolated from patients with ALS. IZUMO2 transcript was present at significantly lower levels in ALS patient fibroblasts as compared to control, non-diseased fibroblasts. These analyses will begin to define the transcriptional landscape of ALS.
Lower ego, better wisdom
Authors: Nguyen Minh-Hoang
Published: September 2022

Wisdom is the word we often hear and even talk about across our life span, as it is passed from generation to generation as knowledge of how to live in every culture. Becoming wiser is the desire of many people because it is generally believed to provide them with better capability of problem-solving, reasoning intelligence, and sagacity. Knowing when to listen to others, being adaptable in dealing with others, and considering long- and short-term consequences are examples of sagacity.So, are there any direct ways to improve our wisdom?
Konsep Ego Manusia Prespektif Sir Muhammad Iqbal
Authors: Nuafal Mohammad Arsyad
Published: September 2022

Manusia adalah mahluk hidup yang paling unik. Keunikannya tidak hanya terletak pada struktur tubuhnya yang Iebih sempurna dibandingkan dengan mahluk hidup Iainnya, namun juga pada rasa ingin tahunya (curiosity). Lalu dalam besar tentang keberadaan dirinya di dunia, Sir Muhammad Iqbal menaruh perhatian yang besar terhadap persoalan eksistensi manusia di duma. Keberadaan diri manusia tidak terlepas dari proses penciptaan, yang merupakan suatu perwujudan ke Maha Kuasaan Allah SWT. Sir Muhammad Iqbal memperlihatkan adanya hubungan yang erat antara manusia sebagai mahluk dengan Allah sebagai Khaliq dalam pembahasannya mengenai konsep ego(Khudi). Sir Muhammad Iqbal juga mengatakan bahwa hakikat manusia adalah segenap kekuatan diri sendiri yang akan menentukan siapa ia. Apabila dirinya sendiri dapat berkembang dengan baik, maka eksistensinya akan diakui. Namun jika dirinya sendiri tidak mengambil prakarsa atau berkeinginan untuk berkembang dan tidak ingin merasakan gejolak batin hidup yang lebih tinggi, maka ruh yang ada padanya perlahan-lahan akan menjadikan dirinya tereduksi kepada benda-benda mati. Untuk membangun kembali (rekontruksi) umat Islam yang telah terpuruk pada kemunduran yang berpangkal kepada kemerosotan humanitas, perlu menata dan membangun kembali tata sistem yang baru dengan mengembangkan potensi diri dan akal manusia yang akan menunjuk pada eksistensi manusia dalam memandang realitas.
Corporate Criminal Liability in Colleges and Schools
Authors: Hussain Shafiq , Lulwani Mumta
Published: September 2022

Corporate Criminal Liability in Colleges and Schools
Differential expression of BUB1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: September 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of BUB1, encoding BUB1 mitotic checkpoint serine/threonine kinase, in the motor neurons of patients with ALS. BUB1 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. BUB1 transcript was present at significantly lower levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
International Jurisprudential Analysis as an Effective Tool of Judicial Practice
Authors: Hussain Shafiq
Published: September 2022

International Jurisprudential Analysis as an Effective Tool of Judicial Practice
Mertic information and surface flow
Authors: Vit Bytynaev
Published: September 2022

Mertic information and surface holography
PERAN EKSPOR dan IMPOR TERHADAP PERTUMBUHAN PDB NEGARA ARAB SAUDI-QOTAR (TAHUN 2010-2020)
Authors: Yuniarti Alfia
Published: September 2022

Faktor penguat dari sebuah pertumbuhan Negara. Masyarakat di sebuah Negara sangat berpangku tangan dengan ekonomi, tanpa ekonomi manusia sulit melakukan aktifitas kehidupan. Ekspor dan Impor merupakan hubungan antar Negara yang terjadi dengan melakukan kerjasama perdagangan dua Negara atau lebih untuk menjalin kerjasama yang baik. Dan juga PDB sebagai jumlah nilai seluruh barang dan jasa yang diproduksi oleh suatu negara dalam periode tertentu atau setiap satu tahun termasuk barang dan jasa yang di produksi oleh perusahaan negara tersebut dan negara lain yang tinggal dinegara bersangkutan. Pada Penelitian ini menggunakan metode kuantitatif yang mana data yang diambil bersumber dari world bank data dan hasil Uji validitas dan Uji regresi linier berganda. Penelitian ini juga dimaksudkan untuk memaparkan dan menjelaskan mengenai: (1) Peran Ekspor-Impor untuk PDB Negara Arab Saudi (2) Peran Ekspor-Impor untuk pendapatan PDB Negara Qotar (3) Peran Ekspor dan Impor terhadap PDB negara Arab Saudi dan Qotar. Pada hasil penelitian menunjukkan bahwa ekspor dan impor berperan penting dalam pertumbuhan ekonomi dinegara Arab Saudi dan Qotar.