bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Hadamard-Type Integral Inequalities Involving Modified Harmonic Exponential Type Convexity
Authors: Shaikh Asif Ali , Hincal Evren , Ntouyas Sotiris K. , Tariboon Jessada , Tariq Muhammad
Published: May 2023

The term convexity and theory of inequalities is an enormous and intriguing domain of research in the realm of mathematical comprehension. Due to its applications in multiple areas of science, the theory of convexity and inequalities have recently attracted a lot of attention from historians and modern researchers. This article explores the concept of a new group of modified harmonic exponential s-convex functions. Some of its significant algebraic properties are elegantly elaborated to maintain the newly described idea. A new sort of Hermite–Hadamard-type integral inequality using this new concept of the function is investigated. In addition, several new estimates of Hermite–Hadamard inequality are presented to improve the study. These new results illustrate some generalizations of prior findings in the literature.
Flexural Behavior of Cold-Formed Steel Composite Floor Infilled with Desert Sand Foamed Concrete
Authors: Yao Bin , Shi Yu , Wang Weiyong , Wang Qiang , Hu Zhiyou
Published: May 2023

Desert sand foamed concrete (DSFC), which offers advantages, such as fire resistance, sound insulation, construction convenience, and environmental benefits, has not been used in cold-formed steel (CFS) composite floors. In this study, four full-scale specimens were designed and tested under four-point bending to investigate the effect of foamed concrete filling and holes. The load–deflection curves and strain distribution at mid-span were measured and analyzed. The experimental results indicated that the failure modes of the CFS composite floors were local buckling at the top flange for specimens without holes and tensile failure at the bottom flange for specimens with holes, respectively, which differed from the web crippling observed in non-composite floors. Moreover, due to the presence of foamed concrete, the flexural stiffness was significantly improved by 117.6% and 73.6% for the specimens without holes and with holes, respectively, while ultimate capacity increased by 224.9% and 121.8%, respectively. Through the nonlinear finite element models validated against experimental results, it was found that the flexural behavior was improved with the increase in CFS thickness and foamed concrete strength. The impact of the holes was not obvious for specimens infilled with holes.
Predictive Factors of Complete Response to Transarterial Chemoembolization in Intermediate Stage Hepatocellular Carcinoma beyond Up-To-7 Criteria
Authors: Saito Natsuhiko , Nishiofuku Hideyuki , Sato Takeshi , Maeda Shinsaku , Minamiguchi Kiyoyuki , Taiji Ryosuke , Matsumoto Takeshi , Chanoki Yuto , Tachiiri Tetsuya , Kunichika Hideki , Marugami Nagaaki , Tanaka Toshihiro
Published: May 2023

Aim: To clarify the prognosis and identify predictors for obtaining a complete response (CR) by transarterial chemoembolization (TACE) in intermediate stage HCC beyond up-to-7 criteria. Methods: Of the 120 patients with intermediate stage HCC who were treated by TACE as the initial treatment from February 2007 to January 2016, 72 finally matched the following inclusion criteria: beyond up-to-7 criteria; Child–Pugh score under 7; and no combined therapy within 4 weeks after the initial TACE. The CR rate and overall survival (OS) were evaluated. Logistic regression analysis was performed to identify predictors of CR. The deterioration of liver function after TACE was also evaluated. Results: The CR rate was 56.9%, and the overall median survival time (MST) was 37.7 months. The MST was 38.7 months in the CR group and 28.0 months in the non-CR group (p = 0.018). HCC within up-to-11 criteria was the only predictor of CR. The CR rate and MST were 70.7% and 37.7 months, respectively, in patients with HCC within up-to-11 criteria and 38.7% and 32.7 months, respectively, in the patients beyond up-to-11 criteria. Deterioration of the Child–Pugh score after the initial TACE and the 2nd TACE occurred in 24.2% and 12.0%, respectively, and deterioration of the modified albumin-bilirubin (mALBI) grade occurred in 17.6% and 7.4%, respectively. Conclusion: TACE can achieve high CR rates with prolonged overall survival for intermediate stage HCC beyond up-to-7 criteria. The predictor of CR was within up-to-11 criteria. Deterioration of liver function was not severe, but requires caution. Multidisciplinary approach as additional treatment after TACE is important.
Sensitivity and Specificity of Different Prognostic Systems in Guiding Surveillance for Metastases in Uveal Melanoma
Authors: Robinson Helena , Eleuteri Antonio , Sacco Joseph J. , Hussain Rumana , Heimann Heinrich , Taktak Azzam F. G. , Damato Bertil , Thompson Alexander J. , Allen Thomas , Kalirai Helen , Coupland Sarah E.
Published: May 2023

Uveal melanoma (UM) metastasises in ~50% of patients, most frequently to the liver. Surveillance imaging can provide early detection of hepatic metastases; however, guidance regarding UM patient risk stratification for surveillance is unclear. This study compared sensitivity and specificity of four current prognostic systems, when used for risk stratification for surveillance, on patients treated at the Liverpool Ocular Oncology Centre (LOOC) between 2007–2016 (n = 1047). It found that the Liverpool Uveal Melanoma Prognosticator Online III (LUMPOIII) or Liverpool Parsimonious Model (LPM) offered greater specificity at equal levels of sensitivity than the American Joint Committee on Cancer (AJCC) system or monosomy 3 alone, and suggests guidance to achieve 95% sensitivity and 51% specificity (i.e., how to detect the same number of patients with metastases, while reducing the number of negative scans). For example, 180 scans could be safely avoided over 5 years in 200 patients using the most specific approach. LUMPOIII also offered high sensitivity and improved specificity over the AJCC in the absence of genetic information, making the result relevant to centres that do not perform genetic testing, or where such testing is inappropriate or fails. This study provides valuable information for clinical guidelines for risk stratification for surveillance in UM.
The Role of Posterior Neural Plate-Derived Presomitic Mesoderm (PSM) in Trunk and Tail Muscle Formation and Axis Elongation
Authors: Stepien Barbara K. , Pawolski Verena , Wagner Marc-Christoph , Kurth Thomas , Schmidt Mirko H. H. , Epperlein Hans-Henning
Published: May 2023

Elongation of the posterior body axis is distinct from that of the anterior trunk and head. Early drivers of posterior elongation are the neural plate/tube and notochord, later followed by the presomitic mesoderm (PSM), together with the neural tube and notochord. In axolotl, posterior neural plate-derived PSM is pushed posteriorly by convergence and extension of the neural plate. The PSM does not go through the blastopore but turns anteriorly to join the gastrulated paraxial mesoderm. To gain a deeper understanding of the process of axial elongation, a detailed characterization of PSM morphogenesis, which precedes somite formation, and of other tissues (such as the epidermis, lateral plate mesoderm and endoderm) is needed. We investigated these issues with specific tissue labelling techniques (DiI injections and GFP+ tissue grafting) in combination with optical tissue clearing and 3D reconstructions. We defined a spatiotemporal order of PSM morphogenesis that is characterized by changes in collective cell behaviour. The PSM forms a cohesive tissue strand and largely retains this cohesiveness even after epidermis removal. We show that during embryogenesis, the PSM, as well as the lateral plate and endoderm move anteriorly, while the net movement of the axis is posterior.
Vascularisation in Deep Endometriosis: A Systematic Review with Narrative Outcomes
Authors: Powell Simon G. , Sharma Priyanka , Masterson Samuel , Wyatt James , Arshad Ilyas , Ahmed Shakil , Lash Gendie , Cross Michael , Hapangama Dharani K.
Published: May 2023

Deep endometriosis (DE) is the most severe subtype of endometriosis, with the hallmark of lesions infiltrating adjacent tissue. Abnormal vascularisation has been implicated in contributing to endometriosis lesion development in general, and how vascularisation influences the pathogenesis of DE, in particular, is of interest. This systematic review followed the PRISMA guidelines to elucidate and examine the evidence for DE-specific vascularisation. A literature search was performed using MEDLINE, Embase, PubMed, Scopus, Cochrane CENTRAL Library and Europe PubMed Central databases. The databases were searched from inception to the 13 March 2023. A total of 15 studies with 1125 patients were included in the review. The DE lesions were highly vascularised, with a higher microvessel density (MVD) than other types of endometriotic lesions, eutopic endometrium from women with endometriosis and control tissue. Vascular endothelial growth factor, its major subtype (VEGF-A) and associated receptor (VEGFR-2) were significantly increased in the DE lesions compared to superficial endometriosis, eutopic endometrium and control tissue. Progestin therapy was associated with a significant decrease in the MVD of the DE lesions, explaining their therapeutic effect. This review comprehensively summarises the available literature, reporting abnormal vascularisation to be intimately related to the pathogenesis of DE and presents potentially preferential therapeutic targets for the medical management of DE.
Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin
Authors: Oh Seyeon , Lee Je Hyuk , Kim Hyoung Moon , Batsukh Sosorburam , Sung Mi Jeong , Lim Tae Hwan , Lee Myoung Hoon , Son Kuk Hui , Byun Kyunghee
Published: May 2023

Poly-L-lactic acid (PLLA) fillers correct cutaneous volume loss by stimulating fibroblasts to synthesize collagen and by augmenting the volume. PLLA triggers the macrophage-induced activation of fibroblasts that secrete transforming growth factor-β (TGF-β). However, whether M2 macrophage polarization is involved in PLLA-induced collagen synthesis via fibroblast activation in aged skin is not known. Therefore, we evaluated the effect of PLLA on dermal collagen synthesis via M2 polarization in an H2O2-induced cellular senescence model and aged animal skin. H2O2-treated macrophages had increased expression levels of the M1 marker CD80 and decreased expression levels of the M2 marker CD163, which were reversed by PLLA. The expression levels of interleukin (IL)-4 and IL-13, which mediate M2 polarization, were decreased in H2O2-treated macrophages and increased upon the PLLA treatment. CD163, IL-4, and IL-13 expression levels were decreased in aged skin, but increased after the PLLA treatment. The expression levels of TGF-β, pSMAD2/SMAD2, connective tissue growth factor (CTGF), alpha-smooth muscle actin (α-SMA), collagen type 1A1 (COL1A1), and COL3A1 were also decreased in aged skin, but increased after the PLLA treatment. Moreover, PLLA upregulated phosphatidylinositol 3-kinase p85α (PI3-kinase p85α)/protein kinase B (AKT) signaling, leading to fibroblast proliferation. PLLA decreased the expression of matrix metalloproteinase (MMP) 2 and MMP3, which destroy collagen and elastin fibers in aged skin. The amount of collagen and elastin fibers in aged skin increased following the PLLA treatment. In conclusion, PLLA causes M2 polarization by increasing IL-4 and IL-13 levels and upregulating TGF-β expression and collagen synthesis in aged skin.
Change of Sleep Stage during Gastroesophageal Reflux in Infants
Authors: Pappa Angeliki , Muschaweck Moritz , Wenzl Tobias G.
Published: May 2023

Introduction: This study intended to explore the existence of a temporal association of changes of sleep stage and gastroesophageal reflux (GER) in infants. Materials and Methods: Documentation of sleep stage and GER was conducted via the use of synchronized polygraphic recording combined with impedance-pH-metry in 15 infants. The total recording-time (Rt) was divided into GER-“window-time” (five seconds before and after the onset of a GER episode), “remaining GER time”, and “GER-free time”, and analyzed for changes of sleep stage. Results: a total of 462 GER episodes were identified during Rt (151.1 h) in all infants. During 1.3 h of window-time; 61 changes of sleep stage (47/h); during 5.9 h of Remaining GER-time, 139 changes of sleep stage (24/h); and during 143.9 h of GER-free time, 4087 changes of sleep stage (28/h) were documented. Change of sleep stage was strongly associated with the onset of GER (p < 0.02 and p < 0.05, respectively). Conclusions: There is a strong temporal association between sleep irregularities, i.e., changes of sleep and episodes of GER in infants. When dealing with disturbed sleep in infants, GER should be considered by caregivers.
Physiological and Biochemical Properties of Cotton Seedlings in Response to Cu2+ Stress
Authors: Zhou Hao , Zhou Ke-Hai , Zhao Gang , Wang Pei-Pei , Yang Dai-Gang , Ma Xiong-Feng , Gao Jun-Shan
Published: May 2023

Copper(II) (Cu2+) is essential for plant growth and development. However, high concentrations are extremely toxic to plants. We investigated the tolerance mechanism of cotton under Cu2+ stress in a hybrid cotton variety (Zhongmian 63) and two parent lines with different Cu2+ concentrations (0, 0.2, 50, and 100 μM). The stem height, root length, and leaf area of cotton seedlings had decreased growth rates in response to increasing Cu2+ concentrations. Increasing Cu2+ concentration promoted Cu2+ accumulation in all three cotton genotypes’ roots, stems, and leaves. However, compared with the parent lines, the roots of Zhongmian 63 were richer in Cu2+ and had the least amount of Cu2+ transported to the shoots. Moreover, excess Cu2+ also induced changes in cellular redox homeostasis, causing accumulation of hydrogen peroxide (H2O2) and malondialdehyde (MDA). Conversely, antioxidant enzyme activity increased, while photosynthetic pigment content decreased. Our findings indicated that the hybrid cotton variety fared well under Cu2+ stress. This creates a theoretical foundation for the further analysis of the molecular mechanism of cotton resistance to copper and suggests the potential of the large-scale planting of Zhongmian 63 in copper-contaminated soils.
Superspreading Surfactant on Hydrophobic Porous Substrates
Authors: Tafireyi Wellington , Littlewood Max , Bandulasena Himiyage Chaminda Hemaka , Trybala Anna , Starov Victor Mikhilovich
Published: May 2023

The wetting behavior of droplets of aqueous surfactant solutions over hydrophobic thin PVDF porous membrane and non-porous hydrophobic PVDF film is investigated for small (~10 μL) droplets of aqueous trisiloxane surfactant solutions: superspreader S 240. The time dependencies of contact angle, droplet radius, wetted area and volume were monitored as well as penetration into the porous substrate. It is shown that the fast spreading of droplets of trisiloxane solutions takes place both in the case of porous and non-porous substrates at a concentration above some critical concentration. It was found that the trisiloxane droplets penetrate into the hydrophobic porous substrates and disappear much faster than on a corresponding hydrophobic non-porous substrate, which was not observed before. This phenomenon is referred to as “superpenetration”.
Theoretical Models Explaining the Level of Digital Competence in Students
Authors: Cabezas-González Marcos , Casillas-Martín Sonia , García-Valcárcel Muñoz-Repiso Ana
Published: May 2023

In the new global scene, digital skills are a key skill for students to seize new learning opportunities, train to meet the demands of the labor market, and compete in the global market, while also communicating effectively in their everyday and academic lives. This article presents research aimed at relating the impact of personal variables on the digital competence of technical problem solving in Spanish students from 12 to 14 years old. A quantitative methodology with a cross-sectional design was employed. A sample of 772 students from 18 Spanish educational institutions was used. For data collection, an assessment test was designed (ECODIES®) based on a validated indicator model to evaluate learners’ digital competence (INCODIES®), taking as a model the European framework for the development of digital competence. Mediation models were used and theoretical reference models were created. The results allowed us to verify the influence of personal, technology use, and attitudinal variables in the improvement of digital skill in technical problem solving. The findings lead to the conclusion that gender, acquisition of digital devices, and regular use do not determine a better level of competence.
Three Years of COVID-19 Pandemic—Is the Heart Skipping a Beat?
Authors: Luchian Maria-Luiza , Demeure Fabian , Higny Julien , Berners Yannick , Henry Jean , Guedes Antoine , Laurence Gabriel , Saidane Lara , Höcher Alexandra , Roosens Bram , Droogmans Steven , Cosyns Bernard , Motoc Andreea
Published: May 2023

In the context of new therapeutic protocols and vaccines developed in the past 3 years, coronavirus 2019 (COVID-19) continues to exert an important impact on the healthcare systems worldwide. Age and a history of cardiovascular or respiratory diseases remain relevant in terms of prognosis for all COVID-19 patients, independent of the viral strain, by conveying a worse outcome and increased rates of in-hospital mortality. Previous studies reported heterogenous cardiovascular manifestations in COVID-19 patients from acute myocarditis or myopericarditis, acute coronary syndromes, stress cardiomyopathy, de novo arrhythmias to pulmonary embolism, or in some rare cases, endocarditis. In this review, we assessed the potential acute, in-hospital and long-term cardiac complications in patients diagnosed with COVID-19.
Neural Crypto-Coding Based Approach to Enhance the Security of Images over the Untrusted Cloud Environment
Authors: Kulkarni Pallavi , Khanai Rajashri , Torse Dattaprasad , Iyer Nalini , Bindagi Gururaj
Published: May 2023

The cloud provides on-demand, high-quality services to its users without the burden of managing hardware and software. Though the users benefit from the remote services provided by the cloud, they do not have their personal data in their physical possession. This certainly poses new security threats for personal and confidential data, bringing the focus back on trusting the use of the cloud for sensitive data. The benefits of the cloud outweigh the concerns raised earlier, and with an increase in cloud usage, it becomes more important for security services to evolve in order to address the ever-changing threat landscape. Advanced encryption standard (AES), being one of the most widely used encryption techniques, has inherent disadvantages related to the secret key that is shared, and predictable patterns in subkey generation. In addition, since cloud storage involves data transfer over a wireless channel, it is important to address the effect of noise and multipath propagation on the transmitted data. Catering to this problem, we propose a new approach—the secure and reliable neural cryptcoding (SARNC) technique—which provides a superior algorithm, dealing with better encryption techniques combined with channel coding. A chain is as strong as the weakest link and, in the case of symmetric key encryption, the weakest link is the shared key. In order to overcome this limitation, we propose an approach wherein the key used for cryptographic purposes is different from the key shared between the sender and the receiver. The shared key is used to derive the secret private key, which is generated by the neural key exchange protocol. In addition, the proposed approach emphasizes strengthening the sub-key generation process and integrating advanced encryption standard (AES) with low-density parity check (LDPC) codes to provide end-to-end security and reliability over wireless channels. The proposed technique was tested against research done in related areas. A comparative study shows a significant improvement in PSNR, MSE, and the structural similarity index (SSIM). The key strength analysis was carried out to understand the strength and weaknesses of the keys generated.
Structure Modulations and Symmetry of Lazurite-Related Sodalite-Group Minerals
Authors: Bolotina Nadezhda B. , Sapozhnikov Anatoly N. , Chukanov Nikita V. , Vigasina Marina F.
Published: May 2023

Lazurite and other lazurite-related minerals (LRMs) containing sulfur in both sulfate and sulfide forms are sodalite-type compounds with various extraframework species, of which the tendency to order leads to structural modulations with a period that is either commensurate or incommensurate with the period of the basic lattice. In this work, the structures of incommensurately modulated monoclinic LRMs are re-examined based on the superstructure of slyudyankaite, formerly known as triclinic lazurite. Similarities and differences between three one-dimensionally modulated LRMs and cubic LRM structures modulated in several directions are discussed. Assumptions are made on how the symmetry of the structure and the composition of the crystal can affect the period of structural modulation.
Genome-Wide Insights into Intraspecific Taxonomy and Genetic Diversity of Argali (Ovis ammon)
Authors: Dotsev Arsen , Koshkina Olga , Kharzinova Veronika , Deniskova Tatiana , Reyer Henry , Kunz Elisabeth , Mészáros Gábor , Shakhin Alexey , Petrov Sergey , Medvedev Dmitry , Kuksin Alexander , Bat-Erdene Ganchimeg , Munkhtsog Bariushaa , Bagirov Vugar , Wimmers Klaus , Sölkner Johann , Medugorac Ivica , Zinovieva Natalia
Published: May 2023

Argali (Ovis ammon), the largest species among all wild sheep, is native to mountainous regions of Central and East Asia, spreading mainly throughout such countries as Tajikistan, Kyrgyzstan, Kazakhstan, Afghanistan, Mongolia, Russia and China. Intraspecific taxonomy of argali remains unclear, and currently, most researchers recognize up to nine subspecies. The aim of our work was to investigate the phylogenetic relationship between populations of O. ammon based on genome-wide SNP analysis. Five subspecies, Altai (O. a. ammon) (n = 6), Gobi (O. a. darwini) (n = 5), Pamir (O. a. polii) (n = 12), Tian Shan (O.a. karelini) (n = 15) and Kyzylkum (O. a. severtzovi) (n = 4), were genotyped using Illumina OvineHD BeadChip. In addition, complete mitogenome sequences from 30 of those samples were obtained. After quality control procedures, 65,158 SNPs were selected for the subsequent analyses. Neighbor-Net dendrogram and principal component analysis (PCA) revealed that the five subspecies could be grouped into four clusters. It was shown that a population from Altai formed a cluster with Gobi subspecies. The highest pairwise FST genetic distance was between O. a. ammon and O. a. severtzovi (0.421) and the lowest were between O. a. polii and O.a. karelini (0.083) and between O. a. ammon and O. a. darwini (0.040) subspecies. Genetic diversity was higher in Central Asian argali as compared to East Asian populations. O. a. severtzovi had an admixed origin and consisted of two genetic components—73.5 ± 0.2% of O. a. polli and 26.5 ± 0.2% of urial (O. vignei). TreeMix analysis revealed a migration event from urial to O. a. severtzovi argali. The analysis of complete mitogenomes supported the results based on whole-genome genotyping. Considering that all the mtDNA sequences of O. a severtzovi belonged to O. ammon and not to O. vignei, we concluded that gene flow in this group was associated with urial males. As this is only the first work on intraspecific taxonomy and genetic diversity of argali based on genome-wide SNP genotyping and the analysis of complete mitogenomes, we suggest that more genetic studies are needed to clarify the status of Gobi and Tian Shan argali.
Both-Column Acetabular Fractures: Does Surgical Approach Vary Based on Using Virtual 3D Reconstructions?
Authors: Leemhuis Judith F. , Assink Nick , Reininga Inge H. F. , de Vries Jean-Paul P. M. , ten Duis Kaj , Meesters Anne M. L. , IJpma Frank F. A. ,   on behalf of the Pelvic Fracture Consortium
Published: May 2023

Displacement of the anterior and posterior column complicates decision making for both-column acetabular fractures. We questioned whether pelvic surgeons agree on treatment strategy, and whether the use of virtual 3D reconstructions changes the treatment strategy of choice. A nationwide cross-sectional survey was performed in all pelvic trauma centers in the Netherlands. Twenty surgeons assessed 15 both-column fractures in 2D as well as 3D. Based on conventional imaging, surgical treatment was recommended in 89% of cases, and by adding 3D reconstructions this was 93% (p = 0.09). Surgical approach was recommended as anterior (65%), posterior (8%) or combined (27%) (poor level of agreement, κ = 0.05) based on conventional imaging. The approach changed in 37% (p = 0.006), with most changes between a combined and anterior approach (still poor level of agreement, κ = 0.13) by adding 3D reconstructions. Additionally, surgeons’ level of confidence increased from good in 38% to good in 50% of cases. In conclusion, surgeons do not agree on the treatment strategy for both-column acetabular fractures. Additional information given by 3D reconstructions may change the chosen surgical approach and increase surgeons’ confidence about their treatment decision. Therefore, virtual 3D reconstructions are helpful for assessing both-column fracture patterns and aid in the choice of treatment strategy.
Ambulatory Resistant Hypertension and Risk of Heart Failure in the Elderly
Authors: Coccina Francesca , Pierdomenico Anna M. , Cuccurullo Chiara , Pizzicannella Jacopo , Trubiani Oriana , Pierdomenico Sante D.
Published: May 2023

(1) Background: The aim of the study was to assess the risk of heart failure (HF) in elderly treated hypertensive patients with white coat uncontrolled hypertension (WUCH), ambulatory nonresistant hypertension (ANRH) and ambulatory resistant hypertension (ARH), when compared to those with controlled hypertension (CH). (2) We studied 745 treated hypertensive subjects older than 65 years. CH was defined as clinic blood pressure (BP) < 140/90 mmHg and 24-h BP < 130/80 mmHg; WUCH was defined as clinic BP ≥ 140/90 mmHg and 24-h BP < 130/80 mmHg; ANRH was defined as 24-h BP ≥ 130/80 mmHg in patients receiving ≤2 antihypertensive drugs; ARH was defined as 24-h BP ≥ 130/80 mmHg in patients receiving ≥3 antihypertensive drugs. (3) Results: 153 patients had CH, 153 had WUCH, 307 had ANRH and 132 (18%) had ARH. During the follow-up (8.4 ± 4.8 years), 82 HF events occurred. After adjustment for various covariates, when compared to CH, the hazard ratio (95% confidence interval) for HF was 1.30 (0.51–3.32), 2.14 (1.03–4.43) and 3.52 (1.56–7.96) in WUCH, ANRH and ARH, respectively. (4) Conclusions: among elderly treated hypertensive patients, those with ARH are at a considerably higher risk of developing HF when compared to CH.
Unexpected Phosphaturic Mesenchymal Tumor of the Femoral Head
Authors: Wang Hui , Li Weijian , Zhang Wenxin , Wang Peng , Wang Shen , Zhang Ruiguo
Published: May 2023

Osteonecrosis of femoral head (ONFH) is clinically common and easily diagnosed via imaging examination, especially when there is a definite cause, such as a fracture, long-term hormonotherapy, etc. However, some rare neoplastic lesions of the femoral head can mimic its image performance in some situations, leading to misdiagnosis. We present the case of a 57-year-old male with bone pain in the left hip joint that persisted for 2 years. CT and MRI images were performed and both were suggestive of ONFH. Unexpectedly, the histopathologic results of left proximal femur resection revealed the diagnosis of phosphaturic mesenchymal tumor (PMT), a rare mesenchymal tumor. His hip pain was obviously relieved after surgery, and the course of 1-year follow-up was uneventful.
Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies
Authors: Brendel Jan M. , Holtackers Robert J. , Geisel Jan N. , Kübler Jens , Hagen Florian , Gawaz Meinrad , Nikolaou Konstantin , Greulich Simon , Krumm Patrick
Published: May 2023

(1) Background and Objectives: Dark-blood late gadolinium enhancement has been shown to be a reliable cardiac magnetic resonance (CMR) method for assessing viability and depicting myocardial scarring in ischemic cardiomyopathy. The aim of this study was to evaluate dark-blood LGE imaging compared with conventional bright-blood LGE for the detection of myocardial scarring in non-ischemic cardiomyopathies. (2) Materials and Methods: Patients with suspected non-ischemic cardiomyopathy were prospectively enrolled in this single-centre study from January 2020 to March 2023. All patients underwent 1.5 T CMR with both dark-blood and conventional bright-blood LGE imaging. Corresponding short-axis stacks of both techniques were analysed for the presence, distribution, pattern, and localisation of LGE, as well as the quantitative scar size (%). (3) Results: 343 patients (age 44 ± 17 years; 124 women) with suspected non-ischemic cardiomyopathy were examined. LGE was detected in 123 of 343 cases (36%) with excellent inter-reader agreement (κ 0.97–0.99) for both LGE techniques. Dark-blood LGE showed a sensitivity of 99% (CI 98–100), specificity of 99% (CI 98–100), and an accuracy of 99% (CI 99–100) for the detection of non-ischemic scarring. No significant difference in total scar size (%) was observed. Dark-blood imaging with mean 5.35 ± 4.32% enhanced volume of total myocardial volume, bright-blood with 5.24 ± 4.28%, p = 0.84. (4) Conclusions: Dark-blood LGE imaging is non-inferior to conventional bright-blood LGE imaging in detecting non-ischemic scarring. Therefore, dark-blood LGE imaging may become an equivalent method for the detection of both ischemic and non-ischemic scars.
A Modified YOLOv8 Detection Network for UAV Aerial Image Recognition
Authors: Li Yiting , Fan Qingsong , Huang Haisong , Han Zhenggong , Gu Qiang
Published: May 2023

UAV multitarget detection plays a pivotal role in civil and military fields. Although deep learning methods provide a more effective solution to this task, changes in target size, shape change, occlusion, and lighting conditions from the perspective of drones still bring great challenges to research in this field. Based on the above problems, this paper proposes an aerial image detection model with excellent performance and strong robustness. First, in view of the common problem that small targets in aerial images are prone to misdetection and missed detection, the idea of Bi-PAN-FPN is introduced to improve the neck part in YOLOv8-s. By fully considering and reusing multiscale features, a more advanced and complete feature fusion process is achieved while maintaining the parameter cost as much as possible. Second, the GhostblockV2 structure is used in the backbone of the benchmark model to replace part of the C2f module, which suppresses information loss during long-distance feature transmission while significantly reducing the number of model parameters; finally, WiseIoU loss is used as bounding box regression loss, combined with a dynamic nonmonotonic focusing mechanism, and the quality of anchor boxes is evaluated by using “outlier” so that the detector takes into account different quality anchor boxes to improve the overall performance of the detection task. The algorithm’s performance is compared and evaluated on the VisDrone2019 dataset, which is widely used worldwide, and a detailed ablation experiment, contrast experiment, interpretability experiment, and self-built dataset experiment are designed to verify the effectiveness and feasibility of the proposed model. The results show that the proposed aerial image detection model has achieved obvious results and advantages in various experiments, which provides a new idea for the deployment of deep learning in the field of UAV multitarget detection.
Associations between Ethnicity and Referrals, Access and Engagement in a UK Adult Burns Clinical Psychology Service
Authors: Shepherd Laura , Hari Ishani , Bamford Lauren
Published: May 2023

Ethnic inequalities exist across healthcare, including access to and experiences and outcomes of mental health services. Access to and engagement with burns clinical psychology services is essential for all patients. This study aimed to explore the ethnic diversity of adults referred to a burns clinical psychology service compared to those admitted to the burns service. It also aimed to investigate associations between ethnicity and indicators of access and engagement (receiving, declining or not attending psychological assessments, receiving psychological therapy and the number of therapy sessions completed). Routinely collected data over eight years were analysed. Analysis revealed an association between ethnicity and referral to the burns clinical psychology service. Patients from White British and Other ethnic backgrounds were less likely to be referred, whereas patients from Black and Asian ethnic groups were more likely to be referred. There were no statistically significant associations between ethnicity and receiving, declining or not attending psychological assessments or receiving psychological therapy. Furthermore, there was no statistically significant difference in the number of psychological therapy sessions received between the ethnic groups. Therefore, patients from ethnic minority groups did not appear to have significant difficulties engaging with the service but further research is recommended.
Visual Multitask Real-Time Model in an Automatic Driving Scene
Authors: Zheng Xinwang , Lu Chengyu , Zhu Peibin , Yang Guangsong
Published: May 2023

In recent years, automatic driving technology has developed rapidly, and environmental perception is one of the important aspects of the technology of automatic driving. To design a real-time automatic driving perception system with limited computational resources, we first proposed a network with faster reasoning speed and fewer parameters by using multitask learning and vision-based recognition technology, which can target the three tasks of traffic target detection, drivable road segmentation, and lane detection that need to be performed simultaneously. Based on the Apollo Scape dataset, the experiment results show that our network is superior to the baseline network in terms of accuracy and reasoning speed and can perform various challenging tasks.
Structural Variation Patterns in Xylem Vessels and Parenchyma Cells and Their Association with Tree Evolution
Authors: He Linghui , Fu Yunlin , Liu Zhigao , Wei Penglian
Published: May 2023

Xylem vessels and parenchyma cells perform functions such as water transport and nutrient storage in trees. However, they are highly variable in different trees. Therefore, this study aimed to explore the structural change patterns in vessels and parenchyma cells in the sapwood, transition wood, and heartwood of tree species with different degrees of evolution. The structural characteristics of the two types of cells in the sapwood, transitional wood, and heartwood were measured in six species with different levels of evolution, namely, Michelia macclurei Dandy, Cinnamomum camphora (L.) presl, Erythrophleum fordii Oliv, Melaleuca leucadendron L., Parashorea chinensis Wang Hsie and Tectona grandis L.F. The results showed that the more evolved species had larger earlywood vessel lumen diameters, thicker walls, and wider hydraulic diameters, as well as smaller latewood vessel densities, reflecting better water transport effectiveness and higher safety. From the sapwood to the transition wood and heartwood, the earlywood vessel lumen diameter of the more primitive species tended to be stable and then decrease, while that of the more evolved species gradually decreased. The latewood vessel density of the more primitive species tended to be stable and then increase, while that of the more evolved species tended to be stable. Additionally, the starch grains of the more primitive species were mainly distributed in the axial or ray parenchyma cells of the sapwood, while those of the more evolved species were abundantly distributed in the axial and ray parenchyma cells of the sapwood, and the distribution of the starch grains was reduced in the transition wood and heartwood. From the sapwood to the heartwood, the ray parenchyma cell fraction tended to be stable in the more primitive species, and tended to be stable before decreasing in the more evolved species. The pit density in the horizontal wall of the ray parenchyma cells tended to be stable and decrease in the more primitive species, while in the more evolved species it tended to be stable or decrease before stabilizing. Overall, trees’ vessels have gradually undergone the optimal selection of vessels during evolution, and the structural variation in the parenchyma cells contributes to their nutrient storage and transport.
Blockchain-Enabled NextGen Service Architecture for Mobile Internet Offload
Authors: Singh Raman , Pervez Zeeshan , Tewari Hitesh
Published: May 2023

The amalgamation of heterogeneous generations of mobile cellular networks around the globe has resulted in diverse data speed experiences for end users. At present, there are no defined mechanisms in place for subscribers of a mobile network operator (MNO) to use the services of third-party WiFi providers. MNOs also have no standardized procedures to securely interact with each other, and allow their subscribers to use third-party services on a pay-as-you-go basis. This paper proposes a blockchain-enabled offloading framework that allows a subscriber of a mobile operator to temporarily use another MNO or WiFi provider’s higher-speed network. A smart contract is employed to allow diverse entities, such as MNOs, brokers and WiFi providers, to automatically execute mutual agreements, to enable the utilization of third-party infrastructure in a secure and controlled manner. The proposed framework is tested using Ethereum’s testnet on the Goerli network using Alchemy and Hardhat. The analysis of the results obtained shows that the proposed technique helps mobile operators to offer improved user experience in the form of average speed and latency. The experiments show that the average time taken to deliver a 500 MB file is reduced from 10.23 s to 0.91 s for the global average scenario, from 6.09 s to 0.50 s for 5G, from 13.50 s to 0.50 s for 4G-LTE, from 41.11 s to 0.49 s for 4G, and from 339.11 s to 0.49 s for the 3G scenario. The results also show that, with WiFi offloading, users from all cellular generations can enjoy a similar quality of services, because delivery time ranges from 0.49 s to 0.91 s for offloaded experiments whereas for the non-offloaded scenario it ranges from 6.09 s to 339.11 s.
Yeast One-Hybrid Screening for Transcription Factors of IbbHLH2 in Purple-Fleshed Sweet Potato
Authors: Fu Danwen , Chen Yahui , Gao Feng
Published: May 2023

The transcription factor IbbHLH2 has been identified as involved in the biosynthesis of anthocyanins in purple-flesh sweet potatoes. However, little is known about the upstream transcription regulators of the promoter of IbbHLH2 in terms of their involvement in anthocyanin biosynthesis. For this study, the transcription regulators of the promoter of IbbHLH2 were screened via yeast one-hybrid assays in purple-fleshed sweet potato storage roots. Seven proteins, namely IbERF1, IbERF10, IbEBF2, IbPDC, IbPGP19, IbUR5GT, and IbDRM, were screened as upstream binding proteins of the promoter of IbbHLH2. The interactions between the promoter and these upstream binding proteins were verified using dual-luciferase reporter and yeast two-hybrid assays. Furthermore, the gene expression levels of transcription regulators, transcription factors, and structural genes involved in the anthocyanin biosynthesis of different root stages of purple and white-fleshed sweet potatoes were analyzed via real-time PCR. The obtained results indicate that IbERF1 and IbERF10 are key transcription regulators of the promoter of IbbHLH2 and are involved in anthocyanin biosynthesis in purple-fleshed sweet potatoes.
The Remains of a Manila Galleon Compass: 16th-Century Nautical Material Culture
Authors: Trejo Rivera Flor , Junco Sánchez Roberto
Published: May 2023

This article reveals the recovery of a compass balance from a Manila galleon that was wrecked in the 16th century off the coast of Baja California, Mexico, and discusses the possibility that it was made in Spain. Based on an analysis of navigation treaties, written in the context of the training of pilots by the Casa de Contratación (House of Trade), it is revealed in detail how nautical compasses were manufactured in Spain during that period. As a result of the review of the nautical literature of that century, it is concluded that the compass was the most important nautical instrument on board and that its simple design allowed any malfunction to be resolved during the journey. In addition, the authors affirm that the design of this compass was very similar to those suggested in the European navigation traditions of the 16th century, and thus, it seems quite possible that the compass rocker found in Baja California was made in the Hispanic world.
Clinical Experience of Using Telemedicine for the Management of Patients Using Continuous Subcutaneous Insulin Infusion in a Highly Complex Latin American Hospital
Authors: Guzman Guillermo Edinson , Escobar María Fernanda , Arias-Valderrama Oriana , Guerra María Angélica , Martínez Veline
Published: May 2023

Introduction: Continuous subcutaneous insulin infusion (CSII) has emerged as a potential solution for diabetes management during the pandemic, as it reduces the need for in-person visits and allows for remote monitoring of patients. Telemedicine has also become increasingly important in the management of diabetes during the pandemic, as it allows healthcare providers to provide remote consultations and support. Here, we discuss the implications of this approach for diabetes management beyond the pandemic, including the potential for increased access to care and improved patient outcomes. Methods: We performed a longitudinal observational study between 1 March 2020 and 31 December 2020 to evaluate glycemic parameters in diabetic patients with CSII in a telehealth service. Glycemic parameters were time in range (TIR), time above range, time below range, mean daily glucose, glucose management indicator (GMI), and glycemic variability control. Results: A total of 36 patients were included in the study, with 29 having type 1 diabetes and 6 having type 2 diabetes. The study found that the proportion of patients achieving target glucose variability and GMI remained unchanged during follow-up. However, in patients with type 2 diabetes, the time in target range increased from 70% to 80%, and the time in hyperglycemia decreased from 2% to 0%. Conclusions: The results of this study suggest that telemedicine is a strategy for maintaining glycemic control in patients using CSII. However, the lack of access to the internet and adequate telemonitoring devices make it difficult to use on a large scale in emerging countries like ours.
Social Inequalities in Mental Health and Self-Perceived Health in the First Wave of COVID-19 Lockdown in Latin America and Spain: Results of an Online Observational Study
Authors: Salas Quijada Carmen , López-Contreras Natalia , López-Jiménez Tomás , Medina-Perucha Laura , León-Gómez Brenda Biaani , Peralta Andrés , Arteaga-Contreras Karen M. , Berenguera Anna , Queiroga Gonçalves Alessandra , Horna-Campos Olivia Janett , Mazzei Marinella , Anigstein Maria Sol , Ribeiro Barbosa Jakeline , Bardales-Mendoza Olga , Benach Joan , Borges Machado Daiane , Torres Castillo Ana Lucía , Jacques-Aviñó Constanza
Published: May 2023

COVID-19 lockdowns greatly affected the mental health of populations and collectives. This study compares the mental health and self-perceived health in five countries of Latin America and Spain, during the first wave of COVID 19 lockdown, according to social axes of inequality. This was a cross-sectional study using an online, self-managed survey in Brazil, Chile, Ecuador, Mexico, Peru, and Spain. Self-perceived health (SPH), anxiety (measured through GAD-7) and depression (measured through PHQ-9) were measured along with lockdown, COVID-19, and social variables. The prevalence of poor SPH, anxiety, and depression was calculated. The analyses were stratified by gender (men = M; women = W) and country. The data from 39,006 people were analyzed (W = 71.9%). There was a higher prevalence of poor SPH and bad mental health in women in all countries studied. Peru had the worst SPH results, while Chile and Ecuador had the worst mental health indicators. Spain had the lowest prevalence of poor SPH and mental health. The prevalence of anxiety and depression decreased as age increased. Unemployment, poor working conditions, inadequate housing, and the highest unpaid workload were associated with worse mental health and poor SPH, especially in women. In future policies, worldwide public measures should consider the great social inequalities in health present between and within countries in order to tackle health emergencies while reducing the health breach between populations.
COVID-19 Pandemic Responses among National Guard Service Members: Stressors, Coping Strategies, Sleep Difficulties and Substance Use
Authors: Mash Holly , Morganstein Joshua , Fullerton Carol , Ursano Robert
Published: May 2023

The National Guard (NG) served as a critical component of the US COVID-19 response while concurrently managing personal COVID-19 responses. Understanding pandemic-related concerns, sleep difficulties, increased substance use, and stress management strategies can promote readiness for subsequent disasters. We surveyed 3221 NG service members (75% Army; 79% enlisted; 52% 30–49 years; 81% male) during COVID-19 (August-November 2020). Almost half were activated in response to COVID-19 (mean = 18.6 weeks) and completed the survey 2–3 months post-activation. Service members indicated great concern about family health (39%), the indefinite nature of the pandemic (35%), and their financial situation (23%). Over one-third reported changes in usual sleep amount, 33% described poor sleep quality, and 21% had trouble falling/staying asleep. Increased substance use was reported by 30%, including increased alcohol (13.5%), tobacco (9%), and caffeine/energy drinks (20.1%) consumption. Chi-square analyses and analyses of variance found those who activated reported more increased tobacco and caffeine/energy drink use versus non-activated, with no sleep difficulties nor alcohol use differences. Helpful stress management strategies included spending time outdoors (53%), exercising (48%), talking to family/friends (38%), and having a daily routine (38%). Specific health-, financial-, and job-related stressors were associated with COVID-19. Incorporating stress management in planning/preventive efforts promotes resilience during disasters.