bluuebunny/crossref_metadata_2025 huggingface dataset:
Electric field enhancement breakdown caused by the pulse formation and transmission of parallel-plate Blumlein line
Authors: Shen Yi , Mao Ye , Liu Yi , Zhang Huang , Xia Liansheng
Published: May 2023

The parallel-plate Blumlein line generates pulsed square waveform and is widely used in the field of pulse power technology. This paper finds that the electromagnetic field leakage of planar transmission line will cause the electric field enhancement phenomenon in the planar transmission line far from the switch during the pulse formation and transmission of parallel-plate Blumlein line. As the electromagnetic wave propagates to the load end, the electric field enhancement phenomenon becomes most serious, and which even causes the bulk breakdown of planar transmission line far from the switch. And the breakdown phenomenon caused by the electromagnetic field leakage has been confirmed by statistics of experimental data. In view of this electric field enhancement effect, this paper proposes an electrode structure design that can reduce the electric field enhancement effect, and the simulation result shows that the optimized electrode structure can significantly reduce the electric field enhancement induced by the electromagnetic field leakage of planar transmission line. Understanding the breakdown phenomenon caused by the electromagnetic field leakage is great significance for the design of anti-electromagnetic radiation and the design of pulsed electric field insulation.
Description of Novel Molecular Factors In Lumbar DRGs And Spinal Cord Factors Underlying Development Of Neuropathic Pain Component In The Animal Model Of Osteoarthritis
Authors: Malek-Chudzik Natalia , Mlost Jakub , Kostrzewa Magdalena , Rajca Jolanta , Starowicz Katarzyna
Published: May 2023

Osteoarthritis (OA) is one of the most common joint disorder, with pain accompanied by functional impairment, as the most pronounced clinical symptom. Currently used pharmacotherapy involves symptomatic treatment, that do not always provide adequate pain relief. This may be due to concomitance of central sensitization and development of neuropathic features in OA patients. Here we performed studies in the animal model of OA to investigate of the neuropathic component.
Intraarticular injection of monoiodoacetate (MIA, 1mg) was used to induce OA in Wistar male rats. Development of pain phenotype was assessed by behavioral testing (PAM test and von Frey’s test), while corresponding changes in dorsal root ganglia (DRGs L3-L5) and spinal cord (SC) gene expression were assessed by means of qRT-PCR technique. We also performed microtomography of OA affected knee joints to correlate level of bone degradation with observed behavioral and molecular changes.
We observed gradually developing remote allodynia after MIA treatment, indicating presence of neuropathic component. Our results showed that, amongst DRGs innervating knee joint, development of central sensitization is most likely due to peripheral input of stimuli through DRG L5. In SC, development of secondary hypersensitivity correlated with increased expression of TAC1 and NPY.
Our studies provided molecular records on abnormal activation of pain transmission markers in DRG and SC during development of OA, that are responsible for the manifestation of neuropathic features. Obtained results increase insight into molecular changes occurring in the neuronal tissue during OA development and may contribute to readdressing treatment paradigms.
Peak Detection in Intracranial Pressure Signal Waveforms: A Comparative Study
Authors: Wei Miaomiao , Krakauskaite Solventa , Subramanian Sreya , Scalzo Fabien
Published: May 2023

Background:
The monitoring and analysis of quasi-periodic biological signals such as electrocardiography (ECG), intracranial pressure (ICP), and cerebral blood flow velocity (CBFV) waveforms plays an important role in the early detection of adverse patient events and contributes to improved care management in the intensive care unit (ICU). This work provides a quantitative evaluation of existing computational frameworks for the automatic extraction of peaks within ICP waveforms.
Methods:
Peak detection techniques based on state-of-the-art machine learning models were evaluated in terms of robustness to varying levels of noise. Evaluation was performed on a dataset of ICP signals assembled from 700 hours of monitoring from 64 neurosurgical patients. The groundtruth of the peak locations was established manually on a subset of 13,611 pulses. Additional evaluation was performed using a simulated dataset of ICP with controlled temporal dynamics and noise.
Results:
The quantitative analysis of peak detection algorithms applied to individual waveforms indicates that all techniques provide acceptable accuracy (RMSE <= 0.15) without noise. In presence of higher level of noise, however, only Kernel ridge regression and Random forest remains below that error threshold while the performance of other techniques significantly deteriorates. Our experiments also demonstrated that tracking methods such as Bayesian inference and LSTM can be applied in a continuous fashion and provide additional robustness in situations where single pulse analysis methods tend to fail such as in presence of missing data.
Conclusion:
While machine learning-based peak detection methods require manually labeled data for training, these models outperform conventional signal processing ones based on handcrafted rules and should be considered for peak detection in modern frameworks. In particular, peak tracking methods that incorporate temporal information between successive periods of the signals have demonstrated in our experiments to provide more robustness to temporary artifacts that commonly arise as part of the monitoring setup in the NICU.
Controllable synthesis of iron-introduced cobalt-iron bimetallic MOFs for rapid removal of tetracycline hydrochloride in water
Authors: Hu Junhao , He Yuting , Shu Tingting , Wang Yingxi , Li Ling
Published: May 2023

For sake of further enhancing the catalytic performance of Co-MOFs and reducing th leaching of Co2+, Fe-doped Co-MOFs was prepared by one-step solvothermal method. The Fex/Co1 − x-MOFs with the best catalytic activity (Fe0.25Co0.75-MOFs) was obtained by changing the doping ratio of Fe3+. Under the action of 0.1g/L Fe0.25Co0.75-MOFs, pH = 7 and 0.2g/L PMS, 98.4% TC can be efficiently degraded only within 30 min, Moreover, the degradation efficiency increased with the increase of the catalyst and PMS. The effects of initial pH on tetracycline hydrochloride degradation was discussed, showing that Fe0.25Co0.75-MOFs can degrade tetracycline hydrochloride with excellent stability. Furthermore, the Fe0.25Co0.75-MOFs exhibits good reusability and stability in cycling experiments. Ultimately, free radical quenching experiments show that both SO4−• and •OH participated in the degradation of tetracycline hydrochloride, and SO4−• plays a major role. Based on some intermediates identified by lc-mg, possible degradation pathways are proposed.
EMI shielding and conductive textiles functionalized with (Ti,Cu) nanomaterials for biomedical applications
Authors: Lopes Cláudia , Ferreira Armando , Correa Marcio A. , Rodrigues André Machado , Mendes Paulo M. , Vaz Filipe
Published: May 2023

This study explores the potential of integrating thin film technology in the design of new and effective Electromagnetic Interference (EMI) shielding materials for textiles and wearables. This application is of particular interest to the textile industry as it can bring new functionalities to wearables and protect humans from prolonged exposure to EM radiation. Three different thin films of pure Ti, pure Cu and Ti-doped with Cu prepared by magnetron sputtering were used to functionalize textile knits based on cotton (code 39 F) and lyocell fibres (62 I). The films displayed different crystalline structures, morphologies, and topographies, which depended on their chemical compositions. The shielding effectiveness (SE) of the functionalized knits against EMI was evaluated in the frequency range of 2 GHz to 8 GHz. Also, the electrical response under stress was assessed since the electrical conductivity is closely related to the EMI shielding effectiveness. The results demonstrate the feasibility of using a thin conductive layer based on Cu to obtain shield textiles with great adhesion and low thickness, providing superior shielding efficiency for EMI by blocking the electrical waves.
Transcriptomic and metabolomic insights into the antimicrobial effect of Leuconostoc mesenteroides or lactic acid on pathogenic Gallibacterium anatis
Authors: Zhang Hua , HuangFu HePing , Qin GuangYong , Wu GuoFang , Wang Lei , Tan ZhongFang
Published: May 2023

Gallibacterium anatis (G. anatis) is an opportunistic poultry pathogen that poses a threat to human health via food chain and can also lead to great economic loss in poultry industries. Our previous studies have demonstrated that the lactic acid producing bacteria Leuconostoc mesenteroides QZ1178 can effectively inhibit the growth of G. anatis by acid production whereas the mechanism is unclear. The current research intended to further probe the molecular mechanism underlying this acid induced antimicrobial effect. The TEM results showed that the cell membrane of G. anatis (GAC026) was damaged and cells were even lysed in the presence of cell free supernatants from Leuconostoc mesenteroides (CFS) or lactic acid. Lactic acid showed more antimicrobial effect than CFS. In this study, the changes in the transcriptome and the metabolic profile of G. anatis under acid stress at different stages have been studied. Using culture medium added with CFS (pH 3.6) or lactic acid (pH 3.6) at 1:1 ratio, 677 differentially transcribed genes and 374 metabolites were detected in G. anatis. The interaction network of all identified differentially expressed genes and metabolites was constructed to outline the potential regulatory genes and dominant pathways in response to acid stress. The results of real-time reverse transcription quantitative PCR (RT-qPCR) further confirmed the results of the transcriptomic analyses. Typically, citrate, lactic acid, L-malic acid, and oxaloacetate were reduced by acid stress in G. anatis, which suggested that lactic acid greatly disturbed energy metabolism. Overall, this work provides comprehensive understanding of stress response and cell death of G. anatis by lactic acid.
Fitting the Discrete Swept Skeletal Representation to Slabular Objects
Authors: Taheri Mohsen , Pizer Stephen M. , Schulz Jörn
Published: May 2023

Statistical analysis of the skeletal structure of slabular objects like groups of hippocampi is valuable for medical researchers as it can be useful for diagnoses and understanding diseases. This work proposes a novel object representation based on model fitting and analysis of the locally parameterized discrete swept skeletal representation of such entities where the model fitting procedure is based on boundary division and surface flattening. The goodness of the model fitting is demonstrated according to the skeletal symmetry, the volume of the implied boundary, and skeletal perturbation. The power of the method is demonstrated by visual inspection and statistical analysis of a synthetic and an actual data set in comparison with an available skeletal representation.
Health-related quality of life and subjective well-being among children aged 9-12 years in eastern China
Authors: Shi Zhao , Cao Aihua , Li Shunping , Wang Jianglin , Zhang Jin , Ratcliffe Julie , Chen Gang
Published: May 2023

Purpose
To investigate the health-related quality of life (HRQoL) and subjective well-being (SWB) of children aged 9–12 years in eastern China, and examine concordance within parent-child dyads.
Methods
Data was collected from 9–12 years students (including their parents) in Shandong Province in 2018. Participants self-completed a hard-copy questionnaire including Child Health Utility 9 Dimension instrument (CHU9D), Pediatric Quality of Life Inventory (PedsQL)™ 4.0 Short Form 15 Generic Core Scales (hereafter the PedsQL), Student’s Life Satisfaction Scale (SLSS), as well as information on socio-demographic characteristics and self-report health status. Spearman’s correlation coefficients and the difference between sub-groups were conducted to assess and compare the agreement on HRQoL and SWB instruments. The concordance of within parent-child was analyzed using Cohen’s kappa coefficient and Bland-Altman plots.
Results
A total of 810 students and 810 parents were invited to participate in the survey. A valid sample of 799 (98.6%) students and 643 (79.4%) parents completed the questionnaire. Students’ mean self-reported CHU9D/PedsQL/SLSS scores were 0.87/83.48/30.90, respectively. The parent proxy’s PedsQL and SLSS scores were 68.61 and 31.23, respectively. The CHU9D was moderately correlated with the PedsQL (r = 0.52). There was a weak correlation between CHU9D and SLSS (r = 0.27). A low level of concordance was observed across all comparisons and in all domains (kappa < 0.20) between parents and their children. Besides, a high level of disagreement was observed between children’s own and fathers’ assessment.
Conclusions
CHU9D and PedsQL instruments have a higher agreement in measuring the HRQoL in children. CHU9D/PedsQL and SLSS instruments showed a low agreement and this suggests that measuring SWB in children potentially may provide further information that might be overlooked by using HRQoL instruments exclusively. Concordance between parents and children was poor. Overall, mothers-children dyads showed a higher concordance than fathers-children dyads.
Boosting the electrochemical performances of LiNi1/3Co1/3Mn1/3O2 cathodes via optimizing calcination temperature for lithium-ion batteries
Authors: Han Qing , Bao Chenguang , Xiao Yongmei , Qiu Xuejing , Yang Xinli
Published: May 2023

Exploration of high-performance cathode materials for rechargeable lithium-ion batteries (LIBs) is highly desirable. The ternary layered oxide LiNi1/3Co1/3Mn1/3O2 (LNCM) is a promising cathode material for LIBs due to its high discharge voltage, large specific capacity, good thermostability and low cost. However, the LNCM cathode still has some limitations such as cationic mixing and low electronic conductivity, which result in poor cycling stability, fast voltage and capacity decay during high-rate cycling. To address these issues, we established a feasible sol-gel method combined with calcination to prepare LNCM, which can significantly improve the electrochemical activity of the LNCM cathode. The developed LNCM‒850/10 cathode displays an initial specific discharge capacity of 215.3 mAh g− 1 at a current rate of 0.2 C, and retains a high reversible capacity of 93.9 mAh g− 1 after 200 cycles. Furthermore, excellent high-rate charge-discharge capability and high-rate cycling performance are also observed in the LNCM‒850/10 cathode. These remarkable results are probably attributable to low Li+/Ni2+ cation mixing degree, good particle morphology and uniform particle size distribution of LNCM‒850/10, which effectively improves the electronic conductivity, lowers the charge transfer resistance, and simultaneously reduce Li+ diffusion distance and accelerate the insertion/extraction of Li+. Our study demonstrates that meticulous control of the calcination temperature of sol-gel synthesized LNCM precursors can boost the development of LNCM cathode suitable for advanced LIBs.
Performance Analysis of 4x4 Modified Wallace Tree Multiplier Using Different Full Adders
Authors: - Hema Chitra S , - Deepakraj R , - Boffi Rajalin R P , - Krupa Shankar S
Published: May 2023

In Embedded and DSP system architectures. Multipliers play a huge role for the mathematical computations. A system’s performance is generally determined by the performance of the multiplier because the multiplier is generally the slowest element in the whole system and also it is occupying more area. Adders play an important role in doing the Multiplication operation for VLSI and digital signal processing applications. In this paper, a modified full adder using multiplexer is proposed to improve the speed of multiplier. In WALLACE tree multiplier the partial sum adders can also be rearranged in a tree like structure. The partial sum adders are implemented with the proposed full adder. The optimization of adder has led to the improvement in performance of multiplier The challenge involved in this kind of multipliers is to realize the complete structure with a minimum number of AND Gates and adder elements. The designs are developed using Verilog HDL and the functional verification was done using Xilinx Vivado18.3. Simulation results are obtained for a 4x4 modified Wallace tree multiplier using various partial sum adders like RCA, CSA and CKA. The results show that the delay is reduced in multiplier using the proposed adder.
Reverse-Phase HPLC (RP - HPLC) study of the complexation of Acetamiprid, Imidacloprid and Carboxin guest molecules with thiophosphorylated calix [6] arene in Dimethylformamide-Acetonitrile-water mobile phase
Authors: Sharma Chandramauly R , Mishra Vijay , Agrawal Yadvendra
Published: May 2023

Reversed-phase high performance liquid chromatography (RP-HPLC) was used to study the host-guest complexation of thiophosphacalixarenes (TPC 1–3) with acetamiprid, imidacloprid, and carboxin as guests. The Onyx Monolithic C 18 column (150 x 0.1 mm) and Phenomenex® were used with UV detection at 254 nm. The mobile phase consisted of dimethylformamide-acetonitrile-water. The association constant of the 1:1 guest-host complexes was determined from the relationship between the capacity factor of the guest and concentration of the thiophosphacalix [6] arene host in the mobile phase. The stability constants are influenced by the confirmation and stereochemical mobility, size, nature, position, and quantity of substituents in the benzene ring of the calixarene skeleton.
Protection of LP-cs on acute alcohol-induced liver and intestine injury
Authors: Xu Feng , Chen Zengqiang , Xie Longteng , Yang Shizhuo , Li Yuying , Wu Junnan , Wu Yuyu , Li Siyuan , Zhang Xie , Ma Yanyan , Liu Yanlong , Zeng Aibing , Xu Zeping
Published: May 2023

The beneficial effects of probiotics have been studied extensively in inflammatory bowel disease, nonalcoholic steatohepatitis (NASH), and alcoholic liver disease (ALD). Probiotic supplements are considered safer and more effective, but the potential mechanisms behind their benefits are unclear. An objective of the current study was to examine the effects of extracellular products of Lactobacillus plantarum on acute alcoholic liver injury. Mice on standard chow diet were supplemented with Lactobacillus plantarum ST-III culture supernatant (LP-cs) for 2 weeks and administered a dose of alcohol at 6 g/kg body weight by gavage. Alcohol-induced liver injury was assessed by measuring plasma alanine aminotransferase (ALT) activity levels, and liver steatosis was determined by triglyceride content. Intestine was measured by H&E staining and tight junction proteins were examined. LP-cs significantly inhibited the alcohol-induced fat accumulation, inflammatory reaction, and apoptosis by inhibiting oxidative stress and ER stress. In addition, LP-cs significantly inhibited the alcohol-induced intestinal injury and endotoxemia. According to these findings, LP-cs alleviates the acute alcohol-induced liver damage by inhibiting oxidative stress and ER stress in one way and suppressing alcohol-induced increased intestinal permeability and endotoxemia in another way. Our findings indicated that LP-cs supplements provided a novel strategy for ALD preventions and treatments.
Proposed diagnostic and prognostic markers of primary malignant hepatic vascular neoplasms
Authors: Yoo Youngeun , Shin Jinho , Jun Eunsung , Koh Eun-Young , Shin Hwa Jeong , Kang Hyo Jeong
Published: May 2023

Background
Primary malignant hepatic vascular tumors with various malignant potentials include epithelioid hemangioendothelioma (EHE) and angiosarcoma (AS), which may overlap pathologically. This study aimed to compare the pathological findings of hepatic EHE with those of AS, in association with patient outcomes.
Methods
Fifty-nine histologically confirmed patients with 34 EHE and 25 AS were admitted to a tertiary hospital from 2003 to 2020. Their EHE and AS pathological features were compared. Immunohistochemistry for CD31, ERG, CAMTA-1, TFE3, P53, and Ki-67 labeling was performed on paraffin-embedded blocks. Markers, along with histological findings, were analyzed for the purposes of diagnostic and prognostic significance by multivariate analysis.
Results
CAMTA-1 was 91.2% positive in EHE, but negative in AS (p = < .001). AS was significantly correlated to an aberrant p53 expression, high Ki-67 labeling, and high mitotic activity, compared to EHE (all, p = < .001). EHE can be classified as low grade (LG) and high grade (HG) using the prognostic values of mitotic activity and ki-67 labeling (sensitivity = 1, specificity = 1). Low grade-EHE showed significantly better overall survival than high grade-EHE (p = .020).
Conclusions
Immunohistochemistry for CAMTA-1, P53, and Ki-67 labeling may help distinguish EHE and AS in histologically ambiguous cases, especially small biopsied tissue. Moreover, the combination of mitotic activity and Ki-67 labeling can be a prognostic factor for EHE with various clinical features.
Mini-laparotomy in emergency general surgery in a second-level hospital in Zambia: a prospective cohort study
Authors: Karachentsev Sergiy , Kadochi Womba
Published: May 2023

Background Being an integral part of the Enhanced Recovery After Surgery methodology, the mini-invasive surgical technique is an important factor in attenuating surgical stress and minimising the risk of postoperative complications. Here we present our experience of utilising the mini-laparotomy (ML) approach in emergency surgery.Methods This prospective clinical study included adult patients operated on for acute abdominal conditions at a second-level hospital in Zambia. Thirty-four patients were explored through ML, and another 34 participants had a standard laparotomy (SL) incision. The size of ML ranged from 6 to 12 cm, with the median being 10.5 cm. ML was not attempted in abdominal malignancy, generalised peritonitis, and as an approach for the relaparotomy procedures. Length of hospital of stay (LOS) and morbidity/mortality were primary endpoints. Secondary outcomes of interest included operating time (OT) and post-operative pain control. Continuous variables were presented as mean with standard deviation or median with ranges; categorical data were given as proportions and percentages. Associations between data were estimated using the t-test and chi-square analysis, as appropriate. LOS was compared by log-rank test and presented graphically by Kaplan-Meier survival curves. A p-value < 0.05 was considered statistically significant.Results The most common procedures performed through ML were resection of the small bowel or colon, closure of hollow viscus perforation or rupture, and adhesiolysis. Employment of ML was associated with reduced LOS (p = 0.0002), shorter OT (p = 0.0003), and minimised need for opioid analgesia (p = 0.01); however, the difference in postoperative complications was not statistically significant (ML: 21% versus SL: 27%, p = 0.57), and mortality was similar (6% in each group).Conclusions As our data showed, ML is a feasible and safe technique that could be used in emergency visceral surgery and abdominal trauma in well-selected patients. Having comparable postoperative morbidity with the SL approach, it might lead to reduced pain and enhanced recovery after the procedure. We proposed an algorithm for the selection of exploration method in patients presented with acute abdominal conditions that could be of help to acute care surgeon operating in a resource-limited setting.
Lysin (K)-Specific Demethylase 1 Inhibition Enhances Proteasome Inhibitor Response and Overcomes Drug Resistance in Multiple Myeloma
Authors: Bandini Cecilia , Mereu Elisabetta , Paradzik Tina , Labrador Maria , Maccagno Monica , Cumerlato Michela , Oreglia Federico , Prever Lorenzo , Manicardi Veronica , Taiana Elisa , Ronchetti Domenica , D'Agostino Mattia , Gay Francesca , Larocca Alessandra , Merlo Giorgio , Hirsch Emilio , Ciarrocchi Alessia , Inghirami Giorgio , Neri Antonino , Piva Roberto
Published: May 2023

Background Multiple myeloma (MM) is an incurable plasma cell malignancy, accounting for approximately 1% of all cancers. Despite recent advances in the treatment of MM, due to the introduction of proteasome inhibitors (PIs) such as bortezomib (BTZ) and carfilzomib (CFZ), relapses and disease progression remain common. Therefore, a major challenge is the development of novel therapeutic approaches to overcome drug resistance, improve patient outcomes, and broaden PIs applicability to other pathologies.Methods We performed genetic and drug screens to identify new synthetic lethal partners to PIs, and validated candidates in PI-sensitive and -resistant MM cells. We also tested best synthetic lethal interactions in other B-cell malignancies, such as mantle cell, Burkitt’s and diffuse large B-cell lymphomas. We evaluated the toxicity of combination treatments in normal peripheral blood mononuclear cells (PBMCs) and bone marrow stromal cells (BMSCs). We confirmed the combo treatment’ synergistic effects ex vivo in primary CD138 + cells from MM patients, and in different MM xenograft models. We exploited RNA-sequencing and Reverse-Phase Protein Arrays (RPPA) to investigate the molecular mechanisms of the synergy.Results We identified lysine (K)-specific demethylase 1 (LSD1) as a top candidate whose inhibition can synergize with CFZ treatment. LSD1 silencing enhanced CFZ sensitivity in both PI-resistant and -sensitive MM cells, resulting in increased tumor cell death. Several LSD1 inhibitors (SP2509, SP2577, and CC-90011) triggered synergistic cytotoxicity in combination with different PIs in MM and other B-cell neoplasms. CFZ/SP2509 treatment exhibited a favorable cytotoxicity profile toward PBMCs and BMSCs. We confirmed the clinical potential of LSD1-proteasome inhibition in primary CD138 + cells of MM patients, and in MM xenograft models, leading to the inhibition of tumor progression. DNA damage response (DDR) and proliferation machinery were the most affected pathways by CFZ/SP2509 combo treatment, responsible for the anti-tumoral effects.Conclusions The present study preclinically demonstrated that LSD1 inhibition could provide a valuable strategy to enhance PI sensitivity and overcome drug resistance in MM patients and that this combination might be exploited for the treatment of other B-cell malignancies, thus extending the therapeutic impact of the project.
Forecasting the effects of habitat fragmentation on the distribution of Sillago larvae and juveniles: a case study in Ka Long Estuary, Vietnam
Authors: Do Anh Ngoc Thi , Do Tuyet Anh Thi , Ashley Matthew , Tran Hau Duc
Published: May 2023

Habitat fragmentation potentially impacts animal diversity due to a decrease in ecological connectivity, especially in estuarine and mangrove environments, where many aquatic organisms spend their early developmental stages on. This study used collections of different species of Sillago larvae and juveniles from 2014 to 2015 in the Ka Long estuary, northern Vietnam to examine the above case based on deep learning models. The combined model, particle swarm optimization - gradient boosting regression, can be used to predict the spatial distribution of Sillago fish in the context of habitat fragmentation, one of the most important parameters to influence in the fish distribution. It reveals that larvae and juveniles of Sillago spp. are more abundant in areas next to mangroves. Based on deep convolutional neural network approach, land use/land cover changed considerably in 2013 and 2023 as mangrove forests and waterbody decreased due to the increase of urbanization. In addition, landscape indices additionally show that the habitat connectivity is decreasing and the number of edges is growing, which indirectly impact the fish larvae and juveniles inhabiting mangroves. Based on genetic algorithm analysis, the present work forecasts Sillago larval and juvenile distribution under the effect of landscape fragmentation in 2033 and 2043, when the Sillago density will have fallen dramatically. Yet, they will choose to reside in mangrove forests, indicating that conserving this environment is essential to maintaining this commercial fish in the study site as well as in adjacent mangrove forests in northern Vietnam.
TNMD system- A better staging in predicting prognosis of patients with stage III colon cancer
Authors: Xu Benjie , Zhu Jiahao , Li Chenyang , Pang Xiangyi , Wang Ren , Wang Xin , Wang Xing , Lian Jie , Lu Haibo
Published: May 2023

Purpose
Our study aimed to emphasize the effect of tumor deposit (TD) on the prognosis of stage III colon cancer patients and suggested the possibility of staging adjustment.
Methods
A total of 14148 patients with stage III colon cancer were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Cox regression analysis was used to evaluate the effect of TD on prognosis. Our study concentrated on the clinicopathological characteristic of patients with TD positive. 956 patients from the Harbin Medical University Cancer Hospital were enrolled as external validation cohort.
Results
Multivariate analysis determined that TD was an independent prognostic risk factor. Patients with regional lymph nodes (RLN) (+), TD (+) were associated with more perineural invasion (13.1% vs. 27.4%), T4 (17.9% vs. 30.0%), poorly differentiated (21.9% vs. 26.4%) and N2 (30.2% vs. 42.7%). Therefore, our study combined the status of TD and four risk factors to construct the tumor-node-metastasis-deposits (TNMD) staging system. In the new staging system, patients with RLN (+), TD (+) were divided into stage IIID (0–1) and stage IIIE (2–4) according to the number of risk factors. The estimated 5- year overall survival (OS) rates were significantly different between IIID and IIIE (61.9% vs 42.1%). In conclusion, the TNMD staging system was a reliable predictor for the OS of patients with stage III colon cancer.
Conclusion
Compared with the TNM system, the TNMD staging could better reflect the effect of TD on patients with stage III colon cancer and provide a more precise prognosis.
Exploring the Role of Government Spending in Fostering Economic Development in Kenya
Authors: Ngigi Caspar Njoroge , Goswami Arvind , Kapoor Harmanpreet Singh , Jangir Rajesh Kumar
Published: May 2023

This research aims to examine the relationship between government spending and G.D.P growth in Kenya, given the lack of consensus on the topic globally. While there is agreement that some level of government expenditure is necessary for economic development, the specific areas of spending that are most beneficial still need to be clarified. Through extensive research, this study will examine the variables of public spending that have the most significant effect on Kenyan economic growth and whether there have been changes in the correlation between public expenditure and G.D.P. over time. This article uses A.R.D.L. model and Support Vector Machine to explore the effect of public spending on the Kenyan economy from 1980–2021. The variables used in the study include G.D.P., infrastructure, education, health, and defense expenditures. The study hypothesizes that increased investment in infrastructure, health, education, and defense spending lead to accelerated G.D.P. growth in Kenya. The results indicate that education has a negative effect on G.D.P. in the short run but a positive effect in the long run, while health and defense spending have a positive impact on G.D.P. Infrastructure spending has adverse impact on G.D.P. in both the short and long run, but its correlation is low. The study suggests that Kenya should increase funding for education and health, maintain defense spending, and improve infrastructure spending while addressing corruption and bureaucracy.
Review about Tissue 3D Printing directed to Organ Transplant and Birth Defects
Authors: Zarante Ignacio , Suárez-Gómez Santiago Andrés
Published: May 2023

End stage disease, trauma or malformation require an organ transplant to treat patients. Low organ supply creates a long waiting list. 3D printed functional artificial organs may be used in future transplant surgeries. 3D printed artificial cells can emulate in vivo tissue. Also, 3D printing has other applications in medicine as a learning tool and surgical guide. Birth defects case reports indicate how 3D printing helped with patient treatment. Further development of this technology is required.
Effect of crop and canopy positions on dwarf cashew flowering pattern
Authors: Pereira Jéssica Soares , DoVale Júlio César , Melo José Wagner da Silva , Neto Francisco das Chagas Vidal , Machado Ingrid Pinheiro , de Pontes Fernanda Carla Ferreira , Melo Dheyne Silva
Published: May 2023

Flower emission pattern in the dwarf cashew tree (Anacardium occidentaleL.) is essential for understanding the possible differences in the number, distribution over time, and/or proportion of the types of flowers affecting the reproductive dynamics of the species during the flowering. Our study aimed to explain the flowering pattern of the dwarf cashew tree, especially the emission and development of the male and hermaphrodite flowers and the influence of the flower distribution in the canopy for fruit production. Therefore, the canopy quadrants (north, south, east, and west) in two flowering seasons and two years (2018 and 2019) were considered. In each bloom, 120 panicles (one per quadrant of each plant) were randomly selected and monitored, in a randomized block design with 10 genotypes and three blocks, where each plant represented a repetition. There were significant differences in the effects of crop and canopy positions on the dwarf cashew tree. The dwarf cashew tree showed similar fluctuations in the average and cumulative number of flowers over time, regardless of flower type, but with a different pattern in the emission of male and hermaphrodite flowers. Male flowers required more time for anthesis during the harvests. Also, the northern quadrant of the crown had a greater quantity of flowers hermaphrodites, possibly due to a higher incidence of radiation because of the predominant path of the sun in the region. However, fruit production in the quadrants showed greater trends in the east and west quadrants, indicating that the flowering and fruiting patterns diverged.
Performance of Heat-tolerant Lettuce Cultivars in Southern New Mexico in 2020—21
Authors: Joukhadar Israel , Tonnessen Brad , Coon Danise , Walker Stephanie
Published: May 2023

Lettuce (Lactuca sativa) is a high-value crop cultivated worldwide. Harvested lettuce acreage in New Mexico, USA, trails the leading lettuce production states (California, Arizona), but growers in New Mexico are interested in expanding their production. For New Mexico farmers to increase lettuce production to reach new markets, information on heat-tolerant cultivar performance is needed. This study was conducted to evaluate six lettuce cultivars described as heat tolerant by seed suppliers or other sources. In 2020 and 2021, we assessed two butterhead types, ‘Anuenue’ and ‘Mikola RG10’; two green leaf types, ‘Muir’ and ‘Tropicana’; and two romaine types, ‘Parris Island Cos’ and ‘Sparx’, in the Jose Fernandez Garden at the New Mexico State University Heritage Farm in Las Cruces, NM. To determine which cultivars and types of lettuce are better suited for southern New Mexico, we measured these variables: marketable harvest weight, number of days from transplant to first bolt, and number of days from transplant to 50% bolted. In 2020, ‘Sparx’, a romaine-type lettuce, had, on average, 32% higher yield compared with the other lettuce types. In 2021 both romaine-type cultivars, Sparx and Parris Island Cos, produced 19% more marketable yield than the other lettuce cultivars. In 2020, ‘Sparx’ was the last to bolt and to reach the 50% bolted stage, whereas in 2021 ‘Mikola RG10’ and ‘Muir’ were the last cultivars to bolt and reach the 50% bolted stage. These results suggest that ‘Sparx’ would be a good potential candidate for farmers in southern New Mexico. ‘Mikola RG10’ and ‘Muir’, butterhead and green leaf type, respectively, demonstrated slower bolting in 2021, indicating they may be useful cultivars for extending lettuce harvest in New Mexico.
TECHNOSTRESS AND ITS INFLUENCE ON TEACHERS COMMITMENT
Authors:   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Marife M. Cruz , Guzman Lorna S. De ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Mikee D. Huelgas ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Mariza A. Inoceno ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Ronald Aron O. Perez ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Cherryl F. Sabandal ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Jaworski J. Salinas ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Angelica T. Sena ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Jonh Paulo A. Sunga ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines., Katrina Teoxon ,   Master of Arts in Education, Graduate School Department, La Consolacion University Philippines.
Published: May 2023

It is not a new impression that technological stress in schools is continually rising to unheard-of levels. Yet, technological stress and its impact on critical instructional characteristics need a review in fresh scenarios like the global COVID-19 issue. This paper focuses on the influence of technological stress to teachers commitment in the context of the challenges face by the teachers inside the classroom. Teachers from Bulacan were selected as a sample in accordance with a descriptive-correlational research methodology. Descriptive and inferential statistics were used to process the data gathered utilizing the instruments that were used. The results showed that the teachers experience moderate level of technostress and a great extent of career commitment.Finally, it was discovered that technostress has no significant influence to teachers commitment. At the conclusion of the study, the practical consequences of these findings on the professional growth of the teachers in this setting are discussed.
ACTINOMYCOSIS MIMICKING A CROHNS DISEASE
Authors:   Surgery Resident, Department of Surgery A, Ibn Sina Hospital, Mohammed V University, Faculty of Medicine and Pharmacy, Rabat, Morocco., Belkouchi Omar , El Malki Omar ,   Surgery Professor, Department of Surgery A, Ibn Sina Hospital, Mohammed V University, Faculty of Medicine and Pharmacy, Rabat, Morocco., Ifrine Lahssan ,   Surgery Professor, Department of Surgery A, Ibn Sina Hospital, Mohammed V University, Faculty of medicine and Pharmacy, Rabat, Morocco., Belkouchi Abdelkader ,   Surgery Professor, Department of Surgery A, Ibn Sina Hospital, Mohammed V University, Faculty of medicine and Pharmacy, Rabat, Morocco., Belkouchi Lina ,   Radiology Resident, Department of Radiology, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Morocco., Saouab Rachida ,   Radiology Professor, Department of Radiology, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Morocco., Aourarh Benayad ,   Gastroenterology Resident, Department of Gastroenterology I, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Morocco., Aourarh Aziz ,   Gastroenterology Professor, Department of Gastroenterology I, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Morocco., Ahmed Jahid ,   Pathology Professor, Department of Pathology, Ibn Sina Hospital, Mohammed V University, Faculty of Medicine and Pharmacy, Rabat, Morocco.
Published: May 2023

Actinomycosis is a slowly progressive chronic granulomatous bacterial infection caused by an anaerobic gram-positive bacillus: Actinomyces Israeli.Thinking about thisdiagnosis in the right iliac fossa is uncommonas it usually shows through a clinical aspect of acute appendicitis, a Crohns disease or even a tumor of the ileocolic region. We report the case of a young female patient admitted for an iliac fossa pain and a palpable mass, mimicking a Crohns disease during laparoscopic exploration, only to conclude its a retained diagnosis of actinomycosis, after doing an ileocecal resection and anatomopathological analysis The purpose of this case report is to focus on the different aspects of this infection in the ileocecal regionwhich can be mistaken at firstand that is only supposed to be treated medically by antibiotics for months, with a simple biopsy to confirm the diagnosissince surgery can be mutilating.
A STUDY OF CORRELATION BETWEEN CHEST HRCT SCORE WITH CT VALUES OF RT-PCR TESTING FOR COVID-19 INFECTION
Authors:   Research Assistant, State Level-ViralResearch and Diagnostic Laboratory(VRDL), Department of Microbiology, Government Medical College, Nagpur-440003, Maharashtra, India., Pathan Sana , Bhise Swati ,   Associate Professor, Department of Microbiology, Government Medical College, Nagpur-440003, Maharashtra, India., Dhokane Nitin ,   Associate Professor, Department of Physiology, Government Medical College, Sindhudurg., Zodpey Sunanda ,   Professor and Head, Department of Microbiology, Government Medical College, Nagpur., Rathod Jawahar ,   Professor, International Radiology, Government Medical College and Trauma Care Centre, Nagpur.
Published: May 2023

Objectives: To compare the performance of chest CT and Real-Time Reverse Transcription-Polymerase Chain Reaction (RTPCR) in the initial diagnostic assessment of the coronavirus disease in COVID-19 patients during pandemic. Methods& Results:In this study we have included 209 clinically suspected cases of COVID-19from Government Medical College, Nagpur who undergone both HRCT chest and RT-PCR. In our study, 3.35% of patients who were RT PCR positive did not have any findings on CT chest, and total positivity by RT-PCR was 100%. Of the patients, 51.67% showed mild HRCT score, 41.19% showed moderate HRCT score, and 4.78% showed severe HRCT score. An inverse relation between CT value of RTPCR and chest HRCT score was detected (p < 0.01). Discussion:The viral load in patients with less severe COVID-19 does not necessarily indicate the need for hospitalization or treatment.Both RT-PCR and Chest CT scan should be used in combination, but chest CT should be used judiciously. Conclusion:Combining RT-PCR with chest CT scans can provide valuable insights into the severity of COVID-19, and thus, the two should be used together for accurate diagnosis.
CLINICOPATHOLOGICAL PROFILE AND OUTCOME OF INFECTION-RELATED GLOMERULONEPHRITIS (IRGN):A SINGLE CENTER EXPERIENCE
Authors:   Assistant Professor, Department of Nephrology Meenakshi Medical College & Research Insitute, Chennai., Kasi Senthilkumar
Published: May 2023

Infection: related glomerulonephritis (IRGN) is an immunological renal injury due to current or recent infections. With the changing face of IRGN over the years, renal biopsy has attained an important role in diagnosing and differentiating this disease from others as well as prognosticating the long-term outcomes. Materials and Methods: This prospective study conducted in a tertiary health care center in south India includes patients with biopsy proven IRGN who presented between October 2017 to august 2019 and their outcomes at 6 months were analyzed. Results: All the patients whose kidney biopsy was suggestive of IRGN were included. Of the 105 patients suspected and screened, eighty two (82) patients were proved to have IRGN. Mean age of presentation was 49.6 years with slight male preponderance (male 43, female 39). About 31.8 % (26) of patients had diabetes. The skin was the most common site of infection 39% (32) followed by respiratory tract infection 22% (18). Hypocomplementemia was present in 90% of patients. Nephrotic range proteinuria was seen in 54.9% (45) cases. About 4.8% cases were proven to have IgA dominant IRGN. 69.5 % (57) of patients had renal failure at presentation, among them 28% (16) required renal replacement therapy. Complete renal recovery was seen in 67% (55) of patients, 14.09% (11) of the patients progressed to chronic kidney disease at 6 months of follow-up and 9.75% (8) of patients reached end-stage renal disease. Oral steroids were given in 37.8 % (31). Around 10.75% (9) patients had persistent proteinuria despite normal renal function. IRGN in adults may no longer be considered as a glomerular disease with favorable outcome and significant number of patients (23.75%) progress to chronicity following this disease.
PRAMANA SHARIRACCORDING TO AYURVEDA: A LITERATURE REVIEW
Authors:   Professor, Rachana Sharir, Ashwin Rural Ayurvedic Mahavidyalaya, Manchihill, Sangamner., Suresh Shimpi Jitendra , Jitendra Shimpi Anupama ,   Associate Professor, Kayachikitsa, Tilak Ayurveda Mahavidya, Pune.
Published: May 2023

Anthropometry is the measurements of human frame which gives scientific techniques and strategies for taking various measurements and observations. The phrase Anthropos means human and Metry way size. it is the technology that defines physical measures of a persons length, shape and purposeful capacities. Ayurvedic literature relating Sharir Rachana furnishes certain description on measurements of body and its factors. In our classics PramanSharir is the term given to this subdivision which depicts the importance of measurements or Anthropometry. Praman, the other way defines the idea of measurements of diverse organic entities.It bears an ample significance in medical carried out technology. earlier than beginning with the Chikitsathats dont forget as work inside the field of medication, the wise doctor must carry out the Pareeksha of Karyadesha i.e. AaturSharira. Acharya Charaka explained DashveedhaPareekshavidhi and PramanPareeksha is one among them. The simple goal in the back of Pareeksha is to get understanding regarding the Bala of Rogi, in which Acharya Sushruta considered it as the principle device to get the records concerning Ayu together with that of Bala.TheSharirPraman is only tool for figuring out the Ayu of an person. The Ayurvedic classical literatures are documented along with many hypothetical ideas. within the classics Anguli (finger breadth) Pramana of different parts of the body is categorically cited Rogi Pariksha may be appreciated through the descriptions of the size of the exceptional body part given with the aid of the our Acharyas. The unit of dimension use for this is the difficulty SwaAnguliPramana (finger breadth) underneath the present scheme of Anthropometry the same old unit of Angula has no longer been utilized as the unit measurement if the very own finger breadth use for this reason this get up the query regarding the exact anatomical points where the Anguli ought to be measured to find out the unit of measurement in every individual,. So its miles vital to explore the concept of Anthropometry practiced in ancient technology as PramanaSharir and its utility in scientific, Para clinical and surgical fields.