bluuebunny/crossref_metadata_2025 huggingface dataset:
PECULIARITIES OF EXECUTION OF CRIMINAL PUNISHMENT IN THE FORM OF CORRECTIONAL LABOR FOR INDIVIDUALS-ENTREPRENEURS
Authors:   Institute of Advanced Training of Personnel of the State Criminal and Executive Service of Ukraine of the Academy of the State Penitentiary Service,  Chernihiv, Ukraine, Ivasheva T.V.
Published: December 2022

Correctional labor is a type of criminal punishment that is rarely used in domestic criminal justice. As of February 1, 2022, there were 63,739 persons on the records of the authorized probation authorities, of which 505 persons (that is, less than 1%) were assigned this type of punishment. The outlined, along with other factors, leads to the fact that aspects of the implementation of this type of criminal punishment do not often fall into the focus of attention of scholars and practitioners. However, the relevance of a full and comprehensive scientific and practical analysis of the mechanism of implementation of this type of criminal punishment is significant, because the practice of performing correctional labor is connected with the application of not only the norms of criminal law, but also labor, tax, financial, social legislation, etc. Today, there is a large number of problems associated with the imperfection of the normative and legal regulation of the relevant legal relations. One of these problems is the lack of a clear legal mechanism for the implementation of criminal punishments in the form of correctional labor assigned to convicts who has the status of natural individuals-entrepreneurs. At the same time, the number of individual entrepreneurs in Ukraine is constantly growing. As of August 7, 2022, 1,993,358 individual entrepreneurs were registered in Ukraine. The regulatory and legal regulations, as well as practical aspects of the execution of criminal punishment in the form of correctional labor, assigned to convicts who have the status of natural individuals-entrepreneurs are analyzed in the article. The essence of problematic aspects that arise in the practice of execution of criminal punishments in the form of correctional labor assigned to natural individuals-entrepreneurs is revealed. Key words: punishment, criminal and executive law, correctional labor, individual-entrepreneur, salary, profit, authorized body on probation issues.
Electroacupuncture at Trigger point gains better pain relief effectiveness than Electroacupuncture at Meridian point: A non-blind randomized trial of chronic neck pain treatment among patients at Traditional Medicine Hospital
Authors: Ly Va Senh , Bui Minh Man Pham , Trinh Dieu Thuong Thi
Published: December 2022

Neck pain is one of the leading causes of disabilities and increasing economic and social burden. Methods affecting the trigger point (TrP) have initially shown good pain relief effectiveness and decreased degree of invasion in patients. The research is conducted to evaluate the effectiveness of Electroacupuncture (EA) at TrP in chronic neck pain (CNP) treatment.

A non-blind randomized study on 125 patients with CNP at Traditional Medicine Hospital in Ho Chi Minh City from September 2020 to June 2021. Patients will be randomly classified into EA at the TrP group or EA at the meridian points group.

There were 62 patients in the TrP group and 63 patients in the other group. After 4 weeks, in the TrP group, the Questionnaire Douleur Saint-Antoine (QDSA) score of 38.2 ± 2.6 decreased to 9.3 ± 5.7, compared with the meridian points group’s QDSA score of 37.8 ± 2.3 decreased to 12.3 ± 7.1. The percentage of patients to reach good pain relief effectiveness of EA at TrP measured by QDSA is 71.0%, statistically significantly higher than 47.6% of the other group. The decrease in the number of TrPs of EA at TrP is higher and has statistical value compared with EA at meridian points.

EA at TrP showed better pain relief effectiveness, has a higher percentage of patients reaching good pain relief effectiveness measured by QDSA, and decreases the number of TrPs more than EA at meridian points does on patients with CNP.
Somatic Symptoms in Major Depressive Disorder: A Cross-sectional Study in a Mental Health Setting, Vietnam
Authors: Ho Phi Nguyen Yen , Pham Chau Minh , Bui Manh Xuan , Tran Ngoc Anh , Tran Nghia Trung , Huynh Quynh Ho Ngoc , Ngo Linh Tich , Nguyen Huy Tien
Published: December 2022

Major depressive disorder (MDD) presents a diverse clinical picture, especially with somatic symptoms, which can lead to negative impacts on the course and prognosis of the illness. This study aimed to (1) assess the prevalence of various somatic symptoms in MDD patients and (2) assess their association with demographic factors.

A total of 345 outpatients diagnosed with MDD according to DSM-5 criteria were enrolled in this cross-sectional study over 6 months. Participants completed a questionnaire that included clinical and demographic information as well as the PHQ-9.

There were 99.7% of patients who had at least one somatic symptom. The common somatic symptoms were fatigue (89.9%), insomnia (87.8%), palpitations (77.7%), headache (69.6%) and dizziness (61.4%). Total PHQ-9 scores and total number of somatic symptoms were found to have a regression relationship with a regression coefficient of 0.14 (t = 6.001, p < 0.001). In multiple logistic regression analysis, female gender was found to be associated with dizziness (odd ratios [OR] = 2.54, 95% confidence interval [CI] 1.53-4.21, p < 0.01), headaches (OR = 1.94, 95% CI 1.16-3.32, p < 0.05), and bowel problems (OR = 0.59, 95% CI 0.37-0.96, p < 0.05); while headaches (OR = 1.73, 95% CI 1.05-2.85, p < 0.05), and stomach problems (OR = 0.56, 95% CI 0.36-0.88, p < 0.05) were associated with age 40 and below.

The study findings provide a resource for clinicians in mental health settings as well as primary care clinics in detecting inexplicable somatic symptoms associated with MDD.
Gastric adenocarcinoma mimicking a submucosal tumor- a diagnostic pitfall in the pediatric population: report of two cases
Authors: Phan Thu Dang Anh , Nguyen Nhu Thi Quynh , Bui Quynh Phuong
Published: December 2022

Pediatric gastric adenocarcinoma (GAC) is sporadic with limited relevant data, and gastric adenocarcinoma, which presents as submucosal, has seldom been reported. The clinical presentation and outcome have not yet been thoroughly understood.

Two boys (10 and 14-year-old) were admitted to the hospital with severe malnutrition. Abdominal CT demonstrated the tumor protruding into the stomach, irregular border, and peritoneal metastasis. Gastric biopsies showed pleomorphic cells, variable size, and increased N/C ratio. These cells were arranged into sheet growth patterns, clusters of cells or incomplete tubules with neutrophils infiltrating. The malignant cells showed strong expression of CK, negativity for CD99, NSE, myogenin, CD3, CD20, ALK, and CD30. Both cases were consistent with poorly differentiated gastric adenocarcinomas, diffuse type with lymphovascular invasion.

Pediatric GAC presented with a more advanced stage and poor differentiation. However, the clinical presentation is similar to adult GAC. Because of data limitations, the diagnosis and treatment of pediatric GAC remain a significant challenge. GAC should be kept in mind, especially when a submucosal tumor-like lesion appears in the stomach. Additional molecular investigations, including E-cadherin or HER2 testing of the tumor samples, may offer more treatment choices for these patients.
The Impact of Walking Programs on Reduction of Menopausal Symptoms: A Systematic Review
Authors: Amanzai Hasina , Sidani Souraya , Munro Kaitlyn , Nadeem Wareesha , Ansari Hanniya , Zia Tooba , Guruge Sepali
Published: December 2022

Aim: To identify types of walking programs and to determine the effects of these programs on menopausal symptoms. 

Background: Menopause is a naturally occurring phenomenon for women and can present with several physical and mental symptoms that are more severely experienced by some individuals. These experiences can be very distressing for women to deal with, especially because of their personal, social, and work lives. The substantial impact of menopausal symptoms direly calls for effective intervention. Specific to menopause, physical activity is a form of intervention that can decrease occurrences and severity of menopausal symptoms. Previous studies have reported the benefits of walking programs in reducing symptoms, yet it is unclear which specific ones are most effective in reducing menopausal symptoms, especially because of the time and efficacy barriers reported by menopausal women. 

Methods: A systematic review was conducted in nine databases for articles published since September 2011, to identify quantitative studies that evaluated walking programs in menopausal women. Two investigators independently screened articles extracted data related to the type and the outcomes of walking programs, and assessed risk of bias. Effect sizes were calculated to quantify the effects of walking programs on menopausal symptoms. 
The Labor and Health Security of Staff During the Wartime: Developing a HR Project
Authors:   State University of Trade and Economics / Kyiv National University of Trade and Economics, Zhukovska Valentyna M.
Published: December 2022

The article analyzes the essence and factors influencing the labor security and health of staff in the process of work. The factors of danger to the health of workers in conditions of war are determined. The purpose of the article is a theoretical generalization of approaches to the use of analytical instruments in the formation of key HR tasks at the stages of project management in the field of labor security of staff in the enterprise. The methodological basis for the implementation of a HR project are formulated; attention is paid to the upgrade by companies of mandatory regulatory and legal regulations in the field of labor protection and arrangement of workplaces. A characterization of factors influencing health in the process of professional activity of workers in the wartime is presented. A checklist is proposed in the context of the functional tasks of HR managers at the stages of project management for the security and health of employees in the workplace. Among the key tasks of a HR manager in project management, the following components are outlined: goals and indicators of efficiency and implementation of the project are formed; the main risks in the event of hazards to staff are identified; probable risks are identified and measures to level the risks of the HR project are formulated; estimated indicators are provided. Emphasis is placed on the communication interaction of staff and the capabilities of the enterprise, which in the first line include: means of operational, remote and emergency communication; organizational regulations on labor protection as the regulatory framework of the project. The indicators and criteria for evaluating the performance of staff in the field of labor protection and fire safety during the implementation of the project are specified. The need for further research to identify the causes of professional and ecological security of personnel of companies is substantiated.
The Features of Assessment of the Efficiency of Industrial Enterprises in the Current Conditions
Authors:   Simon Kuznets Kharkiv National University of Economics, Budarin Oleksii S.
Published: December 2022

The article sets out the substantiations and practical recommendations for assessing the efficiency of industrial enterprises. On the example of assessing the efficiency of business entities of the public sector of the economy by type of economic activity in 2021, which is recommended to be calculated on the basis of applying the mathematical method of constructing an integral taxonomic indicator of development, and evaluating the efficiency of business entities of the public sector of the economy in the regional context, the advantages of its implementation technology have been justified. It is noted that in areas where there is a low level of efficiency of business entities in the public sector of the economy, it is necessary to develop programs that would systematically solve the problems of efficiency and its management. To develop these programs, the necessary step is to improve the information support for assessing the efficiency of business entities in the public sector of the economy on the basis of filling a single database of electronic reporting of business entities of the public sector of the economy and summarizing, consolidating relevant reports in accordance with the Procedure for submitting reports and information on fiscal risks to the Ministry of Economy. The assessment is recommended to be methodically implemented according to the following logic of the stages: 1) the formation of information support for the assessment in the form of a system of indicators, which has an official accounting basis; 2) selection of an analytical method for developing an integral indicator; 3) comparison of the achieved levels of values with the planned or regulatory, or reference ones for determining reserves and diagnosing critical situations; 4) determination of the influence of factors of the external and internal environment; 5) development of management measures to ensure the efficiency of activities. This logic of assessment has a scientific basis and is distinguished by objectivity and reliability
The Problematic Issues Regarding the Activities of Industrial Parks as Instruments of Investment Policy in Ukraine
Authors:   Lviv Polytechnic National University, Seniv Lidiya A. , Komarnytska Bozhena O. ,   Lviv Polytechnic National University
Published: December 2022

The purpose of the article is to study the problematic issues regarding the activities of industrial parks as instruments of investment policy in Ukraine and to analyze the directions of their efficient functioning under martial law. The theoretical foundations of the development of industrial parks, their essence and features of functioning are considered. The normative and legal regulation of industrial parks in Ukraine is characterized. The main draft legislative acts that are at the stages of consideration of the relevant committees are mentioned. The organization of activities of existing Ukrainian industrial parks, in particular the problems of their creation and functioning in modern militarized conditions, is considered. The activity of industrial parks in Ukraine during 2012-2021 is researched. The slow process of creating these sites, the imperfection of domestic legislation and the lack of appropriate funding are noted. The effects of the construction of new industrial parks, in particular conservative and optimistic scenarios, are described. The major problems of industrial parks in Ukraine in wartime are analyzed. The advantages of relocation of enterprises to the territory of existing industrial parks are characterized, which include: the presence of ready-made premises with the necessary communications; provision by the management company of all necessary administrative and other services to residents; cooperation of residents with each other, creation of joint supply chains, the possibility of sending goods through the logistics center located in the same park. The main directions of solving the problems of effective and safe development of industrial parks, which will contribute to the relocation of enterprises, attracting investments and restoring the economy of Ukraine after the war, are examined.
Regional Features of Startups Ecosystem Development: The Entrepreneurial Aspect
Authors:   O. M. Beketov National University of Urban Economy in Kharkiv, Babayev Volodymyr M. , Dymchenko Olena V. ,   O. M. Beketov National University of Urban Economy in Kharkiv, Smachylo Valentyna V. ,   O. M. Beketov National University of Urban Economy in Kharkiv, Rudachenko Olhа O. ,   O. M. Beketov National University of Urban Economy in Kharkiv
Published: December 2022

The article provides the definitions of the concept of both a startup and a startups ecosystem, on the basis of many analyzed scientific works of both domestic and foreign scholars. It is proved that the startups ecosystem is understood as a network that unites various subjects of the innovation process (universities, venture capital companies, marketers, entrepreneurs, audit and consulting agencies, etc.) that interact with each other on the basis of certain agreed «rules of the game». The overall startups ecosystem is taken for an example, being represented by four levels (global (international); national; regional; local). Each of the individual levels creates conditions for the development and successful functioning of startups. The publication presents in more detail the totality of participants in the local startups ecosystem, where it is determined that universities play a rather important role in the processes of formation of innovation ecosystems. The model of the innovation ecosystem of the university is represented by scientific research units, such as the research department, research institute, research sector, which include both the units in which research is carried out (scientific departments, laboratories, centers) and scientific and auxiliary structures (departments of scientific and technical information, research support, financial planning, and personnel). During the formation of an innovation ecosystem of the university, it is important to carry out the process of commercialization of innovative ideas. The importance of developing a startups ecosystem in entrepreneurship is proven. The State authorities are obliged to support, stimulate and encourage the development of entrepreneurship both in the country in general and in its regions in particular. The main programs of development and support of entrepreneurial activity at the regional level are analyzed. It is proved that supporting entrepreneurship in Ukraine by creating a favorable climate for the development of entrepreneurship, identifying all the components that stimulate the formation, attraction of new and expansion of existing small and medium-sized businesses is one of the main directions of implementation of the policy of economic development of the State and its regions.
Formation of a Territorial Cluster in the Dairy Industry
Authors:   National University of Food Technologies, Nikolaienko Svitlana M.
Published: December 2022

The purpose of the article is a comparative analysis and generalization of cluster forms of cooperation of dairy industry enterprises, substantiating the expediency of forming a territorial cluster and determining its main participants. The theoretical basis of the research is the basic provisions of economic theory in terms of the forms of contractual relations of the participants of the interaction. The methodological basis of the research is the methods of generalization, systematization, comparison, and classification. As a result of the study, it was established that the goal of forming a territorial cluster is the sustainability of the resource potential of the necessary quantity and quality for the production of dairy products. The way to implement the defined goal is to support the development of peasant farming. Within the framework of the industry cluster, the goal of coordinating the actions of its participants in the dairy market, forming the horizontal integration of production chains creating added value, is implemented. The purpose of creating an innovation cluster is to ensure innovative leadership on the market and implement the import substitution policy. A sign of an agro-industrial cluster is the formation of complete closed cycles of dairy production, while the goal consists in comprehensive management of production and sales risks. The specified differences in the purposes of forming clusters determine the differences in the tasks implemented by the cluster, its structure, the system of interconnections, performance evaluation indicators, etc. Taking into account the set goal, the structure of the cluster is formed. The structure of the territorial cluster formed with the participation of dairy industry enterprises, farms, transport organizations, logistics structures, and banks will ensure economic, social, and regional effectiveness. The practical significance of the obtained results lies in the possibility of using the formed structure and aggregated functions of the participants of the territorial cluster. The social consequences of the study are related to the possibilities of growth in the number of business entities and the level of employment in the region where the cluster is located. The originality of the research results lies in identifying differences in the purposes of cluster formation, the system of relationships, performance evaluation indicators, and the identification of prerequisites for creating a territorial cluster. Prospects for further research include the development of a methodology for assessing the level of balance in the implementation of the economic interests of all cluster participants.
Vocational English Students’ Perceptions of Learning English Grammar
Authors: Patria Aditya Nur
Published: December 2022

The vocational college is commonly known as a place to prepare students to be ready for work in the industry. Hence, the English language taught in this institution should be more functional or applicable rather than theoretical and analytical. The present study aims to investigate the perception of students taking the English language stream in the Applied Foreign Languages program at a vocational college toward learning English grammar. There are 40 student participants involved. The data are collected using a 13-item questionnaire to identify students’ perception of the importance of learning grammar, the relevance to their study and future career, and their feeling toward learning grammar. Analyzed using descriptive statistics, the data indicate that students consider learning grammar important. Their perception tends to be positive regardless fields of their future career. However, translation is the field career in which many students choose and seem to demonstrate a positive perception toward learning English grammar.
Review of Research on Development of Speech Act Theory and Its Application
Authors: Zou Leilei , Yiye Zhu
Published: December 2022

Speech Act Theory has been the focus of linguistic research since its introduction in the early 1960s. This paper reviews the literature on Speech Act Theory collected from core journals at home and abroad and finds that the theory has been constantly revised and supplemented by domestic and international academics in the process of development; it also finds that Speech Act Theory has been well developed and applied in literature, journalism and communication, education and other fields in recent years, but not much research has been conducted in the field of political speech act. The former focuses on speech strategies, while the latter focuses on individual style differences. By reviewing the development of Speech Act Theory at home and abroad, we can help understand its development prospects and provide a theoretical framework for political speech act research; by reviewing applied research in different fields, we can better understand the application value of Speech Act Theory and provide inspiration on research methods for future political speech act research.
The role of the convention for the protection of human rights and fundamental freedoms and the practice of the European court of human rights in performing law enforcement activities in Ukraine
Authors: Zavhorodnii V.
Published: December 2022

Purpose. The purpose of the article is to clarify the role of the Convention on the Protection of Human Rights and Fundamental Freedoms and the practice of the European Court of Human Rights in the implementation of law enforcement activities in Ukraine. Methodology. The theoretical toolkit of the study consisted of: universal epistemological principles of cognition, complex, dialectical, axiological approaches, general scientific and special scientific methods of cognition. In particular, the following methods of scientific research were used during the research: analysis, synthesis, induction, deduction, structural, systemic. Results. As a result of the study, it was established that the relevant consideration of the legal positions of the ECHR by law enforcement entities in Ukraine ensures their compliance with the norms of the Convention and the Protocols to it, and not their application, as provided by the prescription of Art. 17 of the Law of Ukraine «On the Execution of Decisions and Application of the Practice of the European Court of Human Rights», which extends its effect to national courts. Originality. The work substantiates for the first time the proper forms of implementation of the convention norms by the subjects of law enforcement activity, as well as the need to take into account the legal positions of the ECHR by such subjects. Practical significance. The results of the research can be used for further scientific research in this area, as well as in the law enforcement activities of subjects authorized to implement the decisions of the European Court of Human Rights into the national legal order of Ukraine.
Eksperimen Uji Lentur Balok Beton dengan Bundel Tulangan
Authors: Muhammad Wildan Ubaidillah  , Walujodjati Eko
Published: December 2022

Beton bertulang ialah beton yang dikombinasikan dengan besi tulangan. Luasan besi tulangan yang digunakan harus memenuhi dari nilai minimum yang disyaratkan dengan atau tanpa prategang, dan perencanaan dibuat berdasar pada asumsi bahwa kedua bahan yang dikombinasikan bekerjasama dalam memikul gaya-gaya yang bekerja. Pada perencanaan suatu penampang balok beton bertulang, seringkali tidak terpenuhi karena kebutuhan luas tulangan dan jarak jarak antar tulangan yang disyaratkan. Penelitian ini menggunakan metode eksperimen, yaitu dengan melakukan pengujian kuat lentur balok beton menggunakan tulangan yang dibundel.  Maksud dari penelitian ini ialah untuk mendapatkan salahsatu solusi dari tidak tercapainya persyaratan jarak antar tulangan pada balok lentur dengan mengetahui perbandingan kuat lentur antara balok dengan bundel tulangan dan balok tanpa bundel tulangan. Hasil uji kuat tekan rata-rata beton saat usia 28 hari ialah fâ€™c 17.34 MPa. Nilai kuat lentur rata-rata balok tulangan bundel 2D6 = 8 MPa, dan tulangan tanpa bundel D8 = 5,5 MPa. Balok dengan bundel tulangan lebih kuat dengan perbedaan luas tulangan 12,5 % menghasilkan kekuatan dengan perbedaan 45,4 % melebihi perbedaan luas tulangan.
Pengujian Kuat Lentur dan Geser Balok Beton dengan Bundel Tulangan
Authors: Purinur Rinrin Siti Ratna , Walujodjati Eko
Published: December 2022

Balok adalah bagian dari sistem geser, umumnya merupakan komponen horizontal dalam rangka momen, bertanggung jawab untuk gaya lentur dan geser dengan atau tanpa gaya aksial atau torsi. Dalam konstruksi sering dijumpai permasalahan untuk mendapatkan elemen struktur dengan penampang kecil namun memiliki kekuatan yang besar, serta jarak tulangan yang kecil karena kebutuhan luas tulangan yang besar. Tujuan dari penelitian ini yaitu untuk mendapatkan salah satu solusi dari elemen struktur khususnya balok agar memiliki kekuatan besar dengan persyaratan jaraklantar tulangan yang tidak tercapai, dengan mengetahui perbandingan kuat geser dan lentur pada balok beton tulangan bundel 4Φ6 dan balok beton tulangan tunggal menggunakan proporsi luas penampang tulangan yang sama. Hasil pengujian kuat tekan rata-rata beton silinder saat 28 hari yaitu f’c 12,68 MPa. Balok dengan tulangan bundel (TP 4Φ6) memiliki luas penampang sebesar 105,83 mm2 sedangkan luas tulangan balok dengan tulangan tunggal (TP Φ12) memiliki luas penampang sebesar 106,80 mm2 sehingga luas penampang  bundel tulangan memiliki selisih 0,97 mm2 atau 0,92 % dengan tulangan tunggal. Nilai kuatllentur rata-rata balok tulangan bundel TP 4Φ6 = 9,11 KNm, dan balok tulangan tunggal Φ12 = 7,61 KNm. Nilai kuat geser rata-rata balok tulangan bundel TP 4Φ6 = 58,88 KN, dan balok tulangan tunggal Φ12 = 57,94 KN. Balok dengan bundel tulangan menghasilkan kuat lentur dengan perbedaan 19,71 % dan perbedaan kuat geser 1,62 % , maka balok dengan bundel tulangan 4Φ6 lebih kuat dari pada balok dengan tulangan tunggal Φ12.
Karakteristik Tanah di Daerah Tanjung Kamuning Garut
Authors: Rahman Ardian Nur , Yogaswara Dendi
Published: December 2022

Jalan Prof. KH Anwar Musaddad berada di daerah Kota Garut, Provinsi Jawa Barat adalah sebuah jalan penghubung antara Kecamatan Banyuresmi dan Kecamatan Tanjung Kamuning. Dikarenakan banyaknya kerusakan di Jalan Prof. KH. Anwar Musaddad yang menjadikan tujuan untuk penelitian ini. Tujuan dari penelitian ini adalah untuk mengidentifikasi karakteristik tanah, menganalisis dan klasifikasikan jenis tanah. Metode penelitian yang digunakan adalah metode kuantitatif eksperimental. Pengujian yang dilakukan adalah dengan pengujian di lapangan dan laboratorium. Pengujian di lapangan yaitu dengan Uji Sondir dan pengujian laboratorium meliputi sifat-fisis dan mekanis-tanah. Pengujian-sifat-fisis tanah meliputi-kadar air, berat-jenis, batas-Atterberg dan analisa-saringan. Sedangkan-untuk pengujian-sifat mekanis-tanah meliputi-pengujian kuat geser langsung. Hasil yang didapatkan dari penelitian ini menunjukan jenis tanah yang berada di Ruas Jalan Pro. KH. Anwar Musaddad merupakan tanah pasir dengan klasifikasi USCS masuk kedalam kelompok SP dan SC sedangkan klasifikasi AASHTO masuk kedalam kelompok A-3 dan A-2-7.
Impact of COVID-19 on the clinical course of nephrotic syndrome in children: a single-center study
Authors: Park Min Ji , Eun Jung Kwan , Baek Hee Sun , Cho Min Hyun
Published: December 2022

Purpose: Children with nephrotic syndrome may experience disease relapse or aggravation triggered by various viral infections. Limited studies on the clinical implications of the coronavirus disease 2019 (COVID-19) pandemic in children with nephrotic syndrome have been published worldwide. Therefore, this study aimed to investigate the effects of COVID-19 on the clinical course of nephrotic syndrome in children.Methods: The medical records of 59 patients with idiopathic nephrotic syndrome who visited our hospital between February and June 2022 were retrospectively analyzed. Results: Twenty of the total 59 patients with nephrotic syndrome were diagnosed with COVID-19 during the study period. The mean age at the time of the diagnosis of nephrotic syndrome and COVID-19 in all 20 patients was 4.6±3.5 and 8.9±3.9 years, respectively. Three patients (15%) were diagnosed with nephrotic syndrome relapse during COVID-19 and the relapse rate was similar to them without COVID-19 (20.5%, 8/39 patients). At the time of the COVID-19 diagnosis, fever (85%) and cough (40%) were the most common symptoms. After the diagnosis of COVID-19, all patients showed improvement with symptomatic treatment, including antipyretic analgesics and cold medicine. None of the critical patients required hospitalization or oral antiviral medications.Conclusions: Despite the use of immunosuppressants, the clinical manifestations of COVID-19 in children with nephrotic syndrome were not severe and are expected to be similar to that in the general population. The relapse rate of nephrotic syndrome in children with COVID-19 was also not different from them without COVID-19.
АКТУАЛЬНІ ПРОБЛЕМИ УКЛАДЕННЯ ДОГОВОРІВ НА ТОРГАХ (АУКЦІОНАХ)
Authors: Беляневич Олена
Published: December 2022

У статті досліджуються окремі теоретичні та практичні проблеми укладення господарських договорів на торгах (аукціонах). Незважаючи на поширеність аукціонів у діловій практиці, сучасне законодавство України про торги (аукціони), зокрема і щодо порядку укладення договорів за результатами проведених торгів, залишається несистематизованим. У статті 185 Господарського кодексу України (ГК України) та ст. 650 Цивільного кодексу України містяться загальні норми відсильного характеру, відповідно до яких особливості укладення таких договорів визначаються нормативно-правовими актами, які регулюють діяльність відповідних публічних торгів. Водночас правове регулювання проведення торгів (аукціонів) у різних сферах суспільних відносин стає все більш диференційованим і своєрідним. Звертається увага на те, що, незалежно від законодавчих особливостей проведення торгів, момент визначення переможця торгів слід вважати моментом акцепту його цінової пропозиції.
У багатьох випадках оформлення результатів торгів і визначення переможця (акцепт найкращої оферти) та надання договору купівлі-продажу необхідної письмової форми у вигляді єдиного документа не збігається у часі. Внаслідок цього можуть виникати правові конфлікти, якщо одна зі сторін ухиляється від укладення договору.
Метою статті є обґрунтування належного й ефективного способу захисту права переможця торгів у випадку ухилення продавця/власника майна/уповноваженої особи від укладення договору за результатами торгів.
Аргументовано, що складання у встановленому нормативними актами, які регулюють проведення окремих видів торгів, протоколу торгів є юридичним фактом, із яким пов’язуються відповідні правові наслідки: після проведення аукціону та визначення переможця між продавцем майна та переможцем встановлюється правовий зв’язок у вигляді права переможця на підписання договору купівлі-продажу (надання договору необхідної письмової форми) та кореспондуючого йому обов’язку продавця/власника майна/уповноваженої особи укласти такий договір.
State-Of-The-Art Advances in Duchenne Muscular Dystrophy
Authors: Van Ruiten Henriette , Bushby Katherine , Guglieri Michela
Published: December 2022

Duchenne muscular dystrophy (DMD) is a severe and fatal muscle condition affecting young children. Without interventions, affected boys lose the ability to walk independently by the age of 10 and develop progressive cardiac and respiratory failure. The last 20 years have seen a change in the natural history of DMD following improvements in clinical care and proactive interventions to manage complications of the disease. An international collaboration of DMD experts has created care imperatives for best practice in DMD; these are now available in 30 different languages and are disseminated worldwide. An update of these care recommendations is currently under review.

More recently, the field has seen encouraging scientific progress in regard to new therapeutic approaches of which a large number are currently being evaluated in clinical trials. With time, improvements in clinical care and access to new treatments and innovations are changing the natural course of DMD, from a relentless progressive illness with death in teenage years to a more chronic illness with a good quality of life and increased life expectancy. This is a particularly encouraging time for DMD, and experiences built in the muscular dystrophy field are likely to be of benefit to the development of new approaches and therapies in other rare diseases.
Paradigm Shift for Thrombolysis for Patients with Acute Ischaemic Stroke, from Extension of the Time Window to the Rapid Recanalisation After Symptom Onset
Authors: Seon Jeong Hye , Kim Jei
Published: December 2022

Intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) are useful therapeutic tools to improve functional outcomes after recanalisation of occluded vessels in patients with acute ischaemic stroke. IVT could be performed for more patients by extending the time interval to 4.5 hours from onset to IVT initiation; however, this does not significantly improve functional outcomes. Recent studies indicated that IAT, particularly intra-arterial thrombectomy (IA-thrombectomy), significantly improved functional outcomes after recanalisation of occluded vessels, particularly when the recanalisation was performed within 6 hours of symptom onset. The focus of thrombolysis for acute ischaemic stroke patients is changing from extending the time window for IVT to successfully achieving good functional outcomes with IA-thrombectomy, by performing it within the 6-hour time limit. In this review, we discuss the present status of and limitations of extending IA-thrombectomy for improved functional outcomes after thrombolysis.
New Developments for Parkinson’s Therapy with COMT Inhibitors
Authors: Moloney Juliane
Published: December 2022

Parkinson’s disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. There are currently limited treatment options, including levodopa (L-DOPA), which can be amended in dosing (e.g. schedule and strength), alternative L-DOPA formulations (e.g. quick-acting soluble formulations, extended-release formulations, and continuous infusion), as well as enzyme inhibition (catechol-O-methyl transferase [COMT] and monoamine oxidase B [MAO-B] inhibitors), dopamine agonists (DAs), and combinations thereof. Besides treating symptoms, one of the main concerns in PD is to strike a fine balance between treatment being efficacious without causing dyskinesia, and treatment ‘wearing off’ due to short therapy half-life. Conventional COMT inhibitors, entacapone and tolcapone, have shown promising results in reducing L-DOPA fluctuations and improving motor function; however, the novel once-daily (OD) oral COMT inhibitor opicapone has an exceptionally high binding affinity with the COMT enzyme, translated into a long duration of action, and provided consistent L-DOPA fluctuation control over 24 hours. Opicapone treatment is associated with more efficient endogenous L-DOPA utilisation and less need for exogenous L-DOPA. The long-term benefits of opicapone have been demonstrated in patients initiated on opicapone and those switching from combination treatment with entacapone. The reported reductions in ‘off-time’, a state of decreased mobility, and favourable results for dyskinesia, may have a big impact on patients’ mobility and treatment adherence; however, further assessments are required.
Central Nervous System Disease Associated with Major Viral Haemorrhagic Fever Viruses of Public Health Importance: Challenges in Patient Diagnosis, Evaluation, and Management in Resource-Limited Settings
Authors: Okokhere Peter O. , Rafiu Mojeed O. , Bankole Idowu A.
Published: December 2022

Viral haemorrhagic fever (VHF) viruses cause infectious diseases that are of public health importance. Billions of people from all over the world are at risk of exposure to infection from these viruses with epidemics or outbreaks occurring in both endemic and non-endemic areas. The VHF viruses are largely neglected but are re-emerging as real threats to global health. While the more dramatic clinical presentations (such as bleeding and vascular collapse) are well known, the contribution of features that involve the central nervous system (CNS) to mortality and morbidity are not fully recognised. The diagnosis of VHF in febrile patients with CNS-related features, but who do not present with characteristic bleeding, may be missed or delayed because of a low index of suspicion. The proper evaluation of such patients with CNS disease is hampered by the dearth of neurologists and investigational tools, and weak health systems in resource-limited settings where most of the VHF viruses are endemic. Addressing these constraints would require investment in capacity building and infrastructural development in the affected countries.
Perencanaan dan Pengendalian Produksi Dalam Sistem Logistik (Pendekatan Berbasis Praktikum Laboratorium)
Authors: Ruswandi Nanda , Herlina Rohma , Suri Faras Karningtia , Dianisa Pramesti Adwinda , Sandi Evelyn , Sukarno Iwan , Liperda Rahmad Inca , Lusiani Mirna
Published: December 2022

The concept of Production Planning and Control is closely related to logistics activities, including in determining the production of a product. Production planning and control aims to get a complete picture of how to plan and control production in the industry of each company, so that all costs can be reduced. Production planning, Rough Cut Capacity Planning (RCCP), Material Requirement Planning (MRP), Capacity Requirement Planning (CRP), and Line Balancing are some of the steps that need to be done in providing an overview of the production planning and control system at the "Tamiya" Company. Production planning results in the amount of "Tamiya" production in a certain period by considering SEE and the most appropriate production strategy that results in total costs. MPS validation considerations are the output of the RCCP calculation, a comparison of the ratio of the required capacity to the capacity of the company. The MRP stage reduces production due to material unavailability, the result is the best material scheduling based on the lot sizing method which provides the lowest cost. CRP generates Planned Input and Planned Output per work station to see the balance between load and capacity. Line Balancing functions to balance assignments through the Ranking Position Weight (RPW) and Presedence Diagram methods, getting results in the form of updating the layout of the assignment so that the efficiency of the production line can be improved
Alternatif Penggunaan Sulfit Dalam Pembuatan Chips Umbi Porang (Amorphophallus oncophyllus) Sebagai Peningkatan Nilai Derajat Putih
Authors: Amyranti Mutia , Maftukhah Siti
Published: December 2022

Pencoklatan makanan secara enzimatis dan non-enzimatik merupakan penyebab utama masalah dalam industri makanan. Perubahan warna seperti itu adalah hasil dari aksi polifenol oksidase endogen (pencoklatan enzimatik) diikuti oleh polimerisasi spontan senyawa quinonoid dengan komponen makanan lainnya. Saat ini, penggunaan agen sulfit adalah yang paling banyak digunakan secara pendekatan kimia untuk mengendalikan pencoklatan pada makanan. Namun, kesadaran konsumen tentang risiko yang terkait dengan sulfit dan pengawasan peraturan yang semakin meningkat telah membuat alternatif pengganti penggunaan sulfit. Perlu dilakukan upaya untuk mengurangi tingkat pencoklatan pada chips umbi porang yang disebabkan oleh pencoklatan enzimatik maupun nonenzimatik. Tujuan penelitian ini adalah mempelajari alternatif penggunaan sulfit sebagai agen anti-pencoklatan terhadap nilai derajat putih pada chips umbi porang. Jenis alternatif penggunaan sulfit yang digunakan adalah asam askorbat. Konsentrasi asam askorbat (2, 5 dan 7,5%) dan waktu perendaman (30, 60, 90, 120, 150 dan 180 menit) dipilih sebagai variabel bebas. Kondisi terbaik pencegahan pencoklatan pada chips umbi porang diperoleh dengan menggunakan asam askorbat 5% pada waktu perendaman selama 180 menit dan memperoleh nilai derajat putih tertinggi (79,41).

Kata kunci:  agen anti-pencoklatan, derajat putih, chips porang
Analisis Pengendalian Kualitas Mengidentifikasi Kecacatan Produk X Dengan Metode Statistical Proses Control di PT. XY
Authors: Swendi Vincentius Rico , Efelina Vita
Published: December 2022

PT.XY merupakan  salah  satu  perusahaan  manufaktur yang  bergerak  di  bidang Paper Products di Indonesia. Produk X merupakan salah satu produk yang diproduksi serta banyak digunakan aktivitas karena aman dan nyaman untuk digunakan. jumlah kecacatan pada produk X lebih banyak dari tipe produk jenis lainnya. Berdasarkan data dari bagian pengendalian kualitas PT. XY menunjukan bahwa produk X memperoleh hasil yang didapatkan yang tidak sesuai dengan standar dan kualitas yang telah ditentukan. Tujuan dari penelitian ini adalah mengidentifikasi jenis cacat dan mengetahui faktor-faktor yang sering terjadi dari penyebab utama kecacatan yang terjadi pada produk X dari proses Rewinding menggunakan metode Statistical Proses Control. Ada beberapa Tools yang digunakan untuk mengidentifikasi faktor penyebab utama dari kecacatan pada proses produksi produk X. Diantara Tools tersebut terdiri dari beberapa yaitu, lembar periksa, diagram pareto, diagram sebab akibat, histogram, dan peta kendali. Hasil penelitian menunjukkan bahwa kecacatan pada produk X yang paling sering terjadi yaitu Uneven Cut. Oleh karena itu ada beberapa faktor-faktor yang menyebabkan kecacatan pada produk X terjadi karena faktor metode, faktor mesin, faktor lingkungan, dan faktor manusia yang sangat perpengaruh terhadap produksi.
Identifikasi Bahaya dan Penilaian Risiko Pengujian Conveyor Belt di Laboratorium PT. X Menggunakan Metode Hazard Identification and Risk Assessment
Authors: . Khamaludin , Sumarno Dodi Iwan
Published: December 2022

Dalam upaya menjamin kualitas produk conveyor belt di PT. X, sebelum dikirim ke konsumen perlu dilakukan pengujian produk. Aktivitas pengujian conveyor belt mempunyai potensi terjadi kecelakaan kerja yang akan dialami operator pengujian. Untuk mengantisipasi hal ini perlu dilakukan identifikasi bahaya dan penilaian risiko terhadap Keselamatan dan Kesehatan Kerja (K3)  dari seluruh aktivitas pengujian conveyor belt. Ruang lingkup penelitian ini hanya pada aktivitas pengujian conveyor belt di bagian laboratorium pengujian PT. X. Metode yang digunakan pada Identifikasi Bahaya dan Penilaian Risiko ini adalah dengan menggunakan metode Hazard Identification and Risk Assessment (HIRA) yaitu dengan menetapkan seluruh jenis aktivitas pengujian, bahaya dan risikonya serta menetapkan tingkat keparahan, kemungkinan terjadi, pengendalian yang dilakukan, dan tingkat kepedulian. Operator pengujian sudah cukup peduli terhadap pentingnya pengendalian bahaya risiko dan  seluruh aktivitas pengujian sudah dilengkapi dengan pengendalian berupa penggunaan Alat Pelindung Diri dan pengendalian teknis. Terdapat 16 jenis bahaya dan 12 risiko pada aktivitas pengujian conveyor belt. Nilai IBPR dari seluruh aktivitas pengujian conveyor belt tidak ada yang lebih dari nol atau tidak ada bahaya signifikan.
Analisis Kapasitas Produksi dan Pemenuhan Permintaan dengan Model Sistem Dinamis pada Industri Semen
Authors: Karima Halim Qista , Saputra Mas Aji , Romadlon Fauzan
Published: December 2022

Planning production capacity to meet demand is a challenge for companies. Inventory and fulfillment rate problems become an issue in every planning process. The company aims to minimize inventory and maximize the level of demand fulfillment. Small production activities will minimize total inventory but reduce the level of demand fulfillment, and vice versa. The system dynamic modeling was chosen to model the condition of the production system in determining the medium-term strategy. Dynamic systems are very appropriate for simulating policies and evaluating the conditions of production systems. System dynamic modeling using Vensim software. Based on the model results, it is found that the installed capacity production will be able to meet the demand for the next six years. To meet demand in the next 8 years, the company can increase its grinding machine pro
Hystostructure Features of the Sacra-Caudal (Coccygeal) Dorsal Lateral Muscle when Modeling Posterior Arthodesis of the Ileosacral Joint
Authors: Filimonova G. N. , Diuriagina O. V. , Antonov N. I.
Published: December 2022

Paravertebral muscles play an important role in the development of deformities and degenerative diseases of the spine. The impact of posterior arthrodesis of the ileosacral articulation (sacrum-iliac joint) on the morphological characteristics of the m. sacrocaudalis (coccygeus) dorsalis lateralis of mongrel dogs was studied in animal experiments. Titanium cages were used, followed by stabilization with an external fixation device for 30 days. The advantages of posterior arthrodesis include a small incision, minimal blood loss, preservation of the integrity of most ligaments, and a short immobilization period. Nevertheless, when modeling arthrodesis experimentally in animals, fibrosis of the interstitial space and fatty infiltration in the adjacent muscle were revealed at the end of the experiment, which amounted to 240% and 310% of the intact parameters, respectively. In addition, fibrosis of the vessel membranes of the arterial link was observed. When performing surgical interventions on the spine, traumatization of the muscles should be reduced in order to minimize fibrogenesis and fatty involution of the paravertebral muscles.