bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S6 from High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance
Authors: Saeed Muhammad A. , Peng Bo , Kim Kevin , Rawat Kavita , Kuehm Lindsey M. , Siegel Zoe R. , Borkowski Ariel , Habib Nabih , Van Tine Brian , Sheikh Nadeem , Tuyen Vu , Thorek Daniel L.J. , Fehniger Todd A. , Pachynski Russell K.
Published: May 2024

CD8+ T-cell and CD56+ NK/T cells are the primary source of IL-15-mediated enhancement of sip-T efficacy
Figure S11 from High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance
Authors: Saeed Muhammad A. , Peng Bo , Kim Kevin , Rawat Kavita , Kuehm Lindsey M. , Siegel Zoe R. , Borkowski Ariel , Habib Nabih , Van Tine Brian , Sheikh Nadeem , Tuyen Vu , Thorek Daniel L.J. , Fehniger Todd A. , Pachynski Russell K.
Published: May 2024

Correlation plots between overall survival and sip-T subsets
Figure S10 from High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance
Authors: Saeed Muhammad A. , Peng Bo , Kim Kevin , Rawat Kavita , Kuehm Lindsey M. , Siegel Zoe R. , Borkowski Ariel , Habib Nabih , Van Tine Brian , Sheikh Nadeem , Tuyen Vu , Thorek Daniel L.J. , Fehniger Todd A. , Pachynski Russell K.
Published: May 2024

Correlation plots between PSA and sip-T subsets
Figure S1 from High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance
Authors: Saeed Muhammad A. , Peng Bo , Kim Kevin , Rawat Kavita , Kuehm Lindsey M. , Siegel Zoe R. , Borkowski Ariel , Habib Nabih , Van Tine Brian , Sheikh Nadeem , Tuyen Vu , Thorek Daniel L.J. , Fehniger Todd A. , Pachynski Russell K.
Published: May 2024

Swimmer plots and PSA levels
Figure S9 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S9
Supplementary Table S4 from Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer
Authors: Blise Katie E. , Sivagnanam Shamilene , Betts Courtney B. , Betre Konjit , Kirchberger Nell , Tate Benjamin J. , Furth Emma E. , Dias Costa Andressa , Nowak Jonathan A. , Wolpin Brian M. , Vonderheide Robert H. , Goecks Jeremy , Coussens Lisa M. , Byrne Katelyn T.
Published: May 2024

Supplementary Table S4. Quantification of Cell States.
Figure S5 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S5
Figure S4 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S4
Figure S12 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S12
Figure S10 from ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms
Authors: Tian Jane , Ashique Amir M. , Weeks Sabrina , Lan Tian , Yang Hong , Chen Hung-I Harry , Song Christina , Koyano Kikuye , Mondal Kalyani , Tsai Daniel , Cheung Isla , Moshrefi Mehrdad , Kekatpure Avantika , Fan Bin , Li Betty , Qurashi Samir , Rocha Lauren , Aguayo Jonathan , Rodgers Col , Meza Marchelle , Heeke Darren , Medfisch Sara M. , Chu Chun , Starck Shelley , Basak Nandini Pal , Sankaran Satish , Malhotra Mohit , Crawley Suzanne , Tran Thomas-Toan , Duey Dana Y. , Ho Carmence , Mikaelian Igor , Liu Wenhui , Rivera Lee B. , Huang Jiawei , Paavola Kevin J. , O'Hollaren Kyle , Blum Lisa K. , Lin Vicky Y. , Chen Peirong , Iyer Anjushree , He Sisi , Roda Julie M. , Wang Yan , Sissons James , Kutach Alan K. , Kaplan Daniel D. , Stone Geoffrey W.
Published: May 2024

Supplementary Figure S10
Figure S7 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Authors: Zhang Qunfang , Zheng Fang , Chen Yuchao , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Liu Yunshan , Huang Hongfeng , Lu Weihui , Dai Zhenhua
Published: May 2024

Continuous treatment with HI-TOPK-032 increases the expression of effector molecules but reduces some of the exhaustion molecules in CAR-T cells in vitro.
Figure S6 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Authors: Zhang Qunfang , Zheng Fang , Chen Yuchao , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Liu Yunshan , Huang Hongfeng , Lu Weihui , Dai Zhenhua
Published: May 2024

HI-TOPK-032 enhances the specific effector responses of CAR-T cells to GPC3.
Figure S4 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Authors: Zhang Qunfang , Zheng Fang , Chen Yuchao , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Liu Yunshan , Huang Hongfeng , Lu Weihui , Dai Zhenhua
Published: May 2024

HI-TOPK-032 decreases the expression of LAG-3 and TIM-3 and frequencies of CCR7+PD-1+ subset in CD8+ CAR-T cells of mice bearing subcutaneous Huh7-HCC.
Figure S2 from The TOPK Inhibitor HI-TOPK-032 Enhances CAR T-cell Therapy of Hepatocellular Carcinoma by Upregulating Memory T Cells
Authors: Zhang Qunfang , Zheng Fang , Chen Yuchao , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Liu Yunshan , Huang Hongfeng , Lu Weihui , Dai Zhenhua
Published: May 2024

Gating strategy used for CD8+ CAR-T cells in vitro.
Figure S5 from ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous Cell Carcinoma
Authors: Xu Licheng , Li Wenjing , Liu Danxi , Cao Jing , Ge Jingchun , Liu Xinyu , Wang Yue , Teng Yujian , Liu Pengyan , Guo Xinyue , He Chen , Liu Ming , Tian Linli
Published: May 2024

Figure S5. Mechanism of TAMs-derived-exo-ANXA3 inhibiting ferroptosis in LSCC cells.
Figure S1 from ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous Cell Carcinoma
Authors: Xu Licheng , Li Wenjing , Liu Danxi , Cao Jing , Ge Jingchun , Liu Xinyu , Wang Yue , Teng Yujian , Liu Pengyan , Guo Xinyue , He Chen , Liu Ming , Tian Linli
Published: May 2024

Figure S1. Proteome profiling in LSCC tissue.
Data from Chronic Stress Exacerbates the Immunosuppressive Microenvironment and Progression of Gliomas by Reducing Secretion of CCL3
Authors: Wang Xu , Zhang Long , Zhou Yi , Wang Yan , Wang Xiang , Zhang Yining , Quan Ankang , Mao Yufei , Zhang Yu , Qi Ji , Ren Zhongyu , Gu Linbo , Yu Rutong , Zhou Xiuping
Published: May 2024

Abstract
As understanding of cancer has deepened, increasing attention has been turned to the roles of psychological factors, especially chronic stress–induced depression, in the occurrence and development of tumors. However, whether and how depression affects the progression of gliomas are still unclear. In this study, we have revealed that chronic stress inhibited the recruitment of tumor-associated macrophages (TAM) and other immune cells, especially M1-type TAMs and CD8+ T cells, and decreased the level of proinflammatory cytokines in gliomas, leading to an immunosuppressive microenvironment and glioma progression. Mechanistically, by promoting the secretion of stress hormones, chronic stress inhibited the secretion of the chemokine CCL3 and the recruitment of M1-type TAMs in gliomas. Intratumoral administration of CCL3 reprogrammed the immune microenvironment of gliomas and abolished the progression of gliomas induced by chronic stress. Moreover, levels of CCL3 and M1-type TAMs were decreased in the tumor tissues of glioma patients with depression, and CCL3 administration enhanced the antitumor effect of anti–PD-1 therapy in orthotopic models of gliomas undergoing chronic stress. In conclusion, our study has revealed that chronic stress exacerbates the immunosuppressive microenvironment and progression of gliomas by reducing the secretion of CCL3. CCL3 alone or in combination with an anti–PD-1 may be an effective immunotherapy for the treatment of gliomas with depression.

See related Spotlight by Cui and Kang, p. 514.
Table S8 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

TCGA melanoma patient data
Figure S2 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

Knockdown or knockout of Cdkn2a in mouse melanoma cell lines increases sensitivity to multiple anti-folates but not to de novo pyrimidine synthesis; Knockdown of RB1 does not recapitulate the anti-folate response exhibited by shp16 cells. Related to Figure 3.
FIGURE 4 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

Multiple antifolates induce apoptosis in p16 knockdown cells. A–D, SKMEL28 human melanoma cells were infected with lentivirus expressing a shRNA targeting p16 (shp16). shGFP was used as a control (shCont). A, Cells were treated with the indicated inhibitors (MTX – 0.17 µmol/L; LTX – 0.12 µmol/L) and cytotoxicity was assessed using IncuCyte Cytotox Green reagent. Data from one of three independent experimental replicates are shown (n = 6). Data are mean ± SD. One-way ANOVA at endpoint. ****, P < 0.0001. B, Cells were treated with the indicated inhibitors (MTX – 0.17 µmol/L; LTX – 0.12 µmol/L) for 72 hours, and apoptosis was assessed using Annexin V/PI (propidium iodide) staining by flow cytometry. Data from one of three independent experimental replicates are shown (n = 6). One-way ANOVA of live cells. ****, P < 0.0001. C, Purine metabolite abundance by mass spectrometry. Cells were treated with methotrexate (MTX; 0.17 µmol/L, 72 hours). Data represent one independent experimental replicate (n = 8). Controls are the same data as shown in Fig. 2G. D, Cells were treated with lometrexol (LTX; 0.17 µmol/L) or methotrexate (MTX; 0.17 µmol/L) for 72 hours, and immunofluorescence analysis for γH2AX foci was performed. Data from one of two independent experimental replicates are shown (n = 3). Data are mean ± SD. One-way ANOVA. ****, P < 0.0001; ns = not significant.
Long-Term Clinical Outcomes of Acute Kidney Disease in Patients Receiving Extracorporeal Membrane Oxygenation
Authors: Chan Ming-Jen , Chen Shao-Wei , Fan Pei-Chun , Lee Cheng-Chia , Chen Jia-Jin , Kuo George , Chen Yung-Chang , Chang Chih-Hsiang
Published: May 2024

Introduction: Extracorporeal membrane oxygenation (ECMO) is widely used; however, studies on the long-term outcomes of ECMO are scarce. We investigated the long-term clinical outcomes of acute kidney disease (AKD) in patients receiving ECMO.
Methods: Electronic data (2009–2018) were retrospectively collected from a multicenter database. Patients were divided into two groups (AKD and non-AKD) according to their AKD status 8–90 days after the initiation of ECMO. Inverse probability of treatment weighting (IPTW) was used to balance baseline covariates between the two groups. The primary outcomes were major adverse kidney events (MAKEs) and major adverse cardiovascular events (MACEs), and the secondary outcomes were all-cause readmission, sepsis-related readmission, infection-related readmission, and dementia.
Results: Total 395 patients were eligible for analysis; of them, 160 patients (40.5%) developed AKD. The AKD group had a higher risk of MAKEs (hazard ratio [HR]: 2.06; 95% confidence interval [CI]: 1.68–2.53) than did the non-AKD group. Subgroup analysis revealed that the observed unfavorable effect of AKD on the risk of MAKEs was more pronounced in patients receiving venovenous ECMO than in those receiving venoarterial ECMO (HR: 5.69 vs. 1.85, respectively; P for interaction = 0.004). AKD group had a higher risk of MACE during the initial 3-year post- ECMO in comparison to those without (HR: 1.68; 95% CI: 1.22–2.30). Moreover, the risks of all-cause, sepsis-related, and infection-related readmissions were high in AKD survivors.
Conclusions: AKD is associated with an increased risk of long-term MAKEs and initial 3-year MACE in ECMO recipients. In addition, AKD is associated with increased risks of all-cause, infection-related, and sepsis-related readmissions.
Effortful Swallow Maneuver and Modifications on Swallow Dynamics in Healthy Adults
Authors: Barikroo Ali
Published: May 2024

Introduction: Effortful swallow (ES) is a widely used technique in dysphagia management, believed to strengthen oropharyngeal muscles and enhance swallowing safety and efficiency. Although its impact on the oral phase of swallowing is well documented, its effects on pharyngeal swallowing physiology remain inconsistent. This study aimed to elucidate the effects of ES on swallowing kinematics and timing, addressing existing inconsistencies in the literature. Methods: This study involved 22 healthy adults using archived videofluoroscopic swallowing studies. Participants performed three swallow trials of 10 mL puree under regular conditions and with the ES maneuver. The outcome measures comprised swallow timing and kinematic measures. Swallow timing parameters included time to maximum hyoid and laryngeal excursion, laryngeal vestibule closure (LVC) reaction and duration, pharyngeal constriction duration, pharyngoesophageal segment (PES) opening duration, and swallow duration. Swallow kinematic parameters encompassed hyoid and laryngeal excursions, pharyngeal constriction ratio, and maximum PES width. All variables were analyzed via videofluoroscopy. Paired t tests were used to examine the effect of ES on each outcome measure, with a significance threshold set at p < 0.004. Results: The ES maneuver significantly increased the duration of LVC, pharyngeal constriction, PES opening, and overall swallow duration. It also improved the pharyngeal constriction ratio. However, there were no significant changes in hyoid and laryngeal excursions. Submental muscle activity showed a notable increase during ES. Conclusion: The study demonstrates that ES can effectively modify certain temporal and kinematic aspects of swallowing, particularly by prolonging key phases and enhancing pharyngeal constriction. These findings suggest the potential utility of ES in dysphagia rehabilitation, especially in cases that require prolonged pharyngeal constriction, LVC, and PES opening. However, the limited impact on hyoid and laryngeal excursions along with LVC reaction time indicates that ES may not address all aspects of dysphagia. The findings highlight the need for tailored therapeutic approaches in dysphagia management, considering individual physiological impairment profiles.
Motivational Factors Influencing Accountancy Students of Aldersgate College to Become Certified Public Accountant
Authors: Leonardo Thea Rose , Pumihic Kcy Faith , Pumihic Mercedes B.
Published: May 2024

he study examines the factors influencing students' decisions to pursue accounting certification and their impact on Certified Public Accountant (CPA) qualification. It focuses on academic, financial, social, and career motivations, investigating their relationships with age, gender, and year level. Utilizing the convergent parallel method with a descriptive correlational approach and stratified random sampling, the research was confined to Aldersgate College, Inc. A survey questionnaire was administered to 115 accountancy students across all year levels.
The findings suggest several key insights. Firstly, students aged 19-20, predominantly female, and in their first year exhibit a heightened interest in accounting certification. Financial, social, and career motivations emerge as the most influential factors, with academic motivation following closely behind. Secondly, while significant correlations exist between motivational factors and age/gender, their relationship with year level is comparatively weaker. Notably, motivational factors display a positive association with age and gender, indicating their substantial influence. Conversely, the correlation with year level is marginal, suggesting its limited impact. Consequently, age and gender emerge as more salient variables than year level in driving students' motivation towards CPA certification.
These findings have important implications for accounting educators, policymakers, and practitioners who can use them to develop more effective strategies to motivate accounting students towards achieving CPA certification and success in their careers.
English Reading Performance and Metacognitive Strategies: Implications for Students’ Academic Success
Authors: Mercado Joanna Camille Y. , Manzano Brendalyn A.
Published: May 2024

Education is not a privilege; it is a human right. In response, Sustainable Development Goals' "Let Me Learn" stated that nearly two-thirds of 10-year-olds can hardly read nor perceive and simplify a text, which is even more severe in the Philippines, where reading is in English. Thus, this research sought to examine the relationship between English reading performance and the metacognitive strategies of the grade 7 students on their word recognition and reading comprehension through the Philippine Informal Reading Inventory to determine their reading profile. In correlation, the Metacognitive Reading Strategies Questionnaire was used to self-assess reading strategies. The quantitative-descriptive correlational research design revealed no significant relationship between English reading performance and metacognitive strategies. However, a significant but weak relationship was seen between oral reading and pragmatic-behavioral strategies. It signifies that they can read some words but can hardly comprehend the reading text. The study's product mainly suggested that the variables do not correlate, concluding that to move toward equitable educational outcomes for an increase in their reading level, reimagining how to foster and reinforce the students to discover and strengthen their gradual progress in reading must at least be achieved to meet the expectations and specifications throughout the act of reading.
Level of Implementation of Drug Rehabilitation Program, Treatment and Intervention for Persons Who Use Drugs (PWUD) in Basud, Camarines Norte, Philippines
Authors: Avengoza-Almadrones Rosalie J. , Babala John Kevin A.
Published: May 2024

The study specifically assessed the level of implementation of the Drug Rehabilitation Program, treatment and intervention for Persons Who Use Drugs (PWUD) in Basud, Camarines Norte. It employed descriptive research where 300 respondents participated as respondents. As to the findings, in terms of community preparation PNP Basud initiates advocacy programs on drug education in the community. The least implemented practice was initiating activities in organizing screening for person who use drugs. Meanwhile, in terms of screening, it was found that MHO Basud initiates accomplishing intake form during the screening process. The least practice was initiating schedule check-up by MHO Basud. In terms of assessment, the results showed that MHO Basud ensures other assessment of other mental health conditions using mhGAP IG. The least practice, however, was ensuring request for laboratory/diagnostic test by the MHO Basud. In terms of implementation of intervention, it was revealed that MHO Basud implements community-based treatment for person who uses drugs. The least practice was implements inpatient treatment for person who uses drugs by MHO Basud. Finally, in terms of aftercare program, it was revealed that DILG Basud undertakes community reintegration for person who formerly uses drugs. The least practice, however, was ensuring follow-up for person who formerly uses drugs by the DILG Basud. Comprehensive community-based training programs and educational orientation on drug-related treatment, rehabilitation and interventions may be continuously provided to the implementers of interventions to raise public awareness on the essence, objectives and processes involved in community-based drug rehabilitation.
Localized Video Clip Presentation in Improving The Level of Performance in Science of Grade-IV Learners in The Remote Area Schools at San Marcelino District
Authors: Tiburcio Cesar A.
Published: May 2024

The study determined the effects of localized video presentation Science grade four learners at Sa Marcelino District. In this study, the quasi-experimental design is used in the study, Pre-test and post was administered in the study to determine the effects of the localized video presentation.
The result indicates that localized video presentation has a significant difference in improving the performance of the grade four learners in Science. Moreover, the level of performance of the learners have a positive correlation on the use of intervention.
Thus, the researcher recommends to develop and conduct another study in using localized video presentation to improve the performance of their study.
The Effect of Health Consciousness, Environmental Attitudes and Environmental Knowledge on Green Purchase Intention (Case Study on Corkcicle)
Authors: Fitriani Muchbita , Warganegara Tri Lestira Putri
Published: May 2024

Introduction: Demand for sustainable goods and corporate methods has surged due to growing awareness of environmental and health concerns on a worldwide scale. Consumers are increasingly showing their interest in participating in lifestyles that support health and environmental sustainability. Research on green purchase intentionxis important for further research and analysis. This research aims to test and analyzexthe effect of health consciousness, environmental attitudes, and environmental knowledgexon green purchase intention, using Corkcicle as a case study. Method: This research categorized as quantitative study and will examine the scope ofxthexeffectxof health consciousness, environmentalxattitude, andxenvironmental knowledgexon green purchasingxintention for Corkcicle tumbler products. The population that was the focus of the research was the people of Bandar Lampung and sampling was carried out on 50 respondents using the purposive sampling method. This research employs multiple methods forxdataxanalysis. Result: The results of this research indicate that the three independent variables—environmentalxknowledge, environmental attitudes, and health consciousness—have a positivexeffect onxthe desire to makexgreen purchases. Conclusion: The more likely someone is to intend to buy green goods, the better their level of environmental knowledge, attitudes toward environmental issues, and health awareness.
Cultural Statistics: Behind The Weaving Designs of T’nalak Tapestry
Authors: Arciosa Ramil M.
Published: May 2024

This research describes the multidisciplinary approach in between culture and mathematics/ science concepts, bounded with the different ethno modelling approaches. Like ethno modelling in math-ethno mathematics and physics-ethno physics The static value of the every IPs crafts man, evolve the statistical geometric patterns like the crystallize and geometric weaving designs, volume, areas and its skeletal designs most particularly in the geometric designs of some T’nalak handloom tapestry. When the artistic mind works, dynamism of neurons particles create a weaving designs and patterns with frequencies of wavelength that pointing in a symmetrical and elliptical rays of designs down to his affective and psychomotor of every T’nalak weavers, that’s include that application of cultural statistics. The cultural statistics based on the image processing analysis based on amplitude, wavelength and string theory in perfections of the unique designs of T’nalak weaving patterns.
Exploration Study of Contemporary Batik Motif at The Handayani Community Learning Center Kemirian Village Tamanan District Bondowoso Regency
Authors: Imama Derrida Dhini , Irianti Agus Hery Supadmi , Kusumawardani Hapsari
Published: May 2024

The learning center community for public named Handayani is an Small and Medium Enterprise located in Kemirian Village, Tamanan Subdistrict, Bondowoso Regency. PKBM handayani is a non-formal educational institution and also known as a batik business that produces written batik, stamped batik, and semi batik. This study aims to identified any typical Motif of contemporary batik Bondowoso whose produced by PKBM Handayani. This research was using a qualitative descriptive approach with observation, interviews, and documentation both offline and online as the data collection techniques. The result for this research are the identification of nine Motifs of batik which consist by the classification of ornaments and colors, and also the symbols and meanings contained in the Motifs. This research also shows that the role of Bondowoso Regency government has been held well in the development of PKBM Handayani implemented as a facilitator, motivator, and catalyst. The researcher hopes that through this research, PKBM Handayani can be recognized and being widely known by the wider community and also increase its sales and their business development.
Belgian Blue Indonesia
Authors: Residiwati Gretania , Tuska Habib Syaiful Arif , Asfiya Nayla Lubi , Zuhria Farida Puspita , Khalmat Nursalsabila
Published: May 2024

Buku dengan judul Belgian Blue Indonesia ini membahas tentang salah satu breed sapi unggul di dunia, yakni Belgian Blue, yang berasal dari negara Belgia, Eropa. Belgian Blue merupakan salah satu breed sapi yang dikenal karena keistimewaannya, terutama dalam hal massa otot yang superior atau dikenal dengan fenomena double-muscle. Buku ini mengulas berbagai karakteristik dari Belgian Blue dan perbedaannya dengan breed sapi lain, mencakup anatomi, fisiologi, kualitas karkas, metabolisme, sistem reproduksi, serta metode pemeliharaan yang dapat diterapkan dalam pengembangan Belgian Blue di Indonesia. Buku ini juga membahas bagaimana sejarah munculnya Belgian Blue di Belgia, sejarah kedatangan Belgian Blue di Indonesia, hingga pentingnya kehadiran Belgian Blue di Indonesia. Selain itu, buku ini juga membahas aspek-aspek pemeliharaan yang perlu diperhatikan dalam pengembangan Belgian Blue di Indonesia, seperti nutrisi yang tepat, penyakit dan gangguan kesehatan yang mungkin muncul, manajemen kesehatan, serta perawatan khusus yang diperlukan oleh Belgian Blue. Penulis berharap buku ini dapat memberikan informasi tentang manfaat dan potensi pengembangan Belgian Blue di Indonesia sehingga kehadiran Belgian Blue dapat memberikan kontribusi yang signifikan terutama dalam meningkatkan kualitas dan kuantitas ketersediaan daging sapi di Indonesia. Selamat membaca.
Termodinamika Kimia
Authors: Hakim Lukman
Published: May 2024

Jika kimia dimaknai sebagai cabang ilmu yang mempelajari materi, perubahannya, dan energi yang menyertai perubahan tersebut; termodinamika adalah sepertiga dari ilmu kimia. Termodinamika adalah lingua franca bagi kimiawan dan ilmuwan di bidang lain untuk berdiskusi mengenai energi. Namun, termodinamika awalnya berkembang dari upaya rekayasawan (engineer) untuk membangun mesin uap dengan efisiensi tinggi sehingga termodinamika sering kali dibahas dengan sudut pandang dan studi kasus yang kurang relevan bagi kimiawan. Buku ini ditulis dengan tujuan memandu kimiawan untuk mulai mempelajari termodinamika secara sistematis melalui perspektif ilmu kimia. Muatan buku ini dirancang untuk mahasiswa yang sedang menempuh kuliah di program studi yang condong ke bidang ilmu kimia dan untuk kimiawan yang tertarik menginvestasikan waktunya dalam mempelajari termodinamika. Buku ini tidak memuat jurus kilat untuk peneliti sibuk yang ingin menguasai termodinamika dalam 24 jam. Meskipun peran termodinamika dan urgensi mempelajarinya telah diakui secara umum, termodinamika tidak memiliki reputasi sebagai subjek yang banyak dikuasai oleh kimiawan. Citra termodinamika sebagai cabang ilmu yang sulit dipelajari boleh jadi bersumber dari kecenderungan kimiawan yang berupaya menjauhi matematika. Termodinamika dipandang sulit karena dituliskan dalam bahasa matematika, tetapi mustahil mendiskusikan termodinamika secara komprehensif tanpa matematika. Termodinamika merupakan sains makroskopik yang saat ini telah memiliki akses ke tingkat mikroskopik melalui mekanika statistik yang ditulis dalam bahasa matematika. Dengan dukungan instrumentasi dan metode komputasi, perkembangan ilmu kimia modern semakin menyelam dalam ke ranah mikroskopis. Galileo mengatakan bahwa alam menuliskan hukum-hukumnya dalam bahasa matematika. Menjauhi matematika hanya akan menutup pintu akses bagi kimiawan untuk mengembangkan bidang ilmunya sendiri. Pemahaman tentang termodinamika merupakan modal penting bagi kimiawan untuk turut berkontribusi dalam menyelesaikan persoalan energi global dan berperan dalam pengembangan ilmu kimia modern.
Pajak E-Commerce
Authors: Pratiwi Amelia Ika , Susenohaji S , Kusumastuti Dinda Amelia , Prajnasari Puspa Ratri
Published: May 2024

Perdagangan elektronik, yang juga dikenal sebagai e-commerce, telah mengubah dunia bisnis secara signifikan. Pajak dalam e-commerce semakin penting seiring dengan pertumbuhan pesat perdagangan melalui media online. Keberhasilan dalam bisnis e-commerce di era digital saat ini, tidak lepas dari pemahaman peraturan perpajakan dan strategi perencanaan pajak karena pajak dan e-commerce adalah bidang yang terus berkembang dan kompleks. Buku ini menjelaskan beberapa elemen utama pajak dalam bisnis e-commerce dan mengapa hal ini menjadi topik menarik yang menjadi perhatian pemerintah dan pengusaha. Bisnis berbasis e-commerce sering dihadapkan pada permasalahan pajak. Munculnya berbagai masalah perpajakan dikarenakan banyaknya transaksi online. Pajak penjualan atau di Indonesia sering disebut sebagai Pajak Pertambahan Nilai, adalah salah satu masalah utama. Bagaimana pajak penjualan berlaku untuk barang atau layanan yang dibeli melalui internet? Apakah penjual, pembeli, atau kedua belah pihak yang harus membayar pajak ini? Hal ini semakin rumit karena aturan perpajakan penjualan yang berbeda di setiap negara. Transaksi e-commerce yang terkadang terjadi lintas negara, membuat perpajakan di bisnis ini semakin rumit. Pajak penghasilan juga menjadi salah satu hal penting lain yang perlu diperhatikan. Bagaimana para pelaku bisnis e-commerce dapat mematuhi kewajiban pajak penghasilan yang berlaku di beberapa negara? Karena perusahaan e-commerce dapat melakukan transaksi lintas batas tanpa batasan fisik yang jelas, hal ini membuat perpajakan internasional di lini bisnis ini menjadi semakin kompleks. Peraturan privasi dan perlindungan data pribadi juga merupakan masalah lain yang perlu dipertimbangkan dalam e-commerce, bukan hanya peraturan pajak. Bagaimana perusahaan e-commerce mengelola data pelanggan mereka, dan bagaimana ini berkaitan dengan perpajakan? Perencanaan pajak juga sangat penting untuk bisnis e-commerce. Bisnis online sering melakukan pendekatan perpajakan yang dapat membantu mereka secara legal dalam mengoptimalkan kewajiban pajak mereka. Penggunaan insentif perpajakan yang tepat, manajemen organisasi perusahaan, dan penggunaan teknik akuntansi yang tepat dapat juga dilakukan sebagai pertimbangan dalam perencanaan pajak bisnis e-commerce Buku ini menggaris bawahi betapa pentingnya kerja sama internasional dalam mengatasi masalah perpajakan e-commerce. Karena bisnis e-commerce beroperasi di banyak negara, kerja sama antarnegara menjadi semakin penting untuk menyelesaikan masalah perpajakan lintas batas.
Sukses Menembus Jurnal Internasional “Q1”
Authors: Nugroho Eko , Adli Danung Nur
Published: May 2024

Publikasi menjadi modal penting bagi pengembangan karir akademisi dan peneliti. Jumlah publikasi juga bisa menjadi modal bagi akademisi dalam mengikuti kompetisi hibah-hibah dana penelitian. Bahkan, publikasi sudah menjadi syarat bagi mahasiswa program doktor untuk meraih gelar akademik. Namun, banyak akademisi dan peneliti pemula di Indonesia yang kesulitan mempublikasikan hasil penelitiannya pada jurnal internasional bertaraf Q1. Seorang akademisi dan peneliti pemula yang hendak menulis suatu artikel jurnal sering kali menghadapi kebingungan dari mana harus memulai dan apa yang harus ditulis pertama kali. Di sisi lain, upaya untuk menceritakan hasil-hasil penelitian dalam suatu format tulisan yang mudah dimengerti dan bisa diterima (acceptable) pada jurnal internasional bertaraf Q1 bukanlah pekerjaan yang mudah. Selain kendala keterbatasan Bahasa Inggris, penulisan artikel yang akan dipublikasikan pada suatu jurnal internasional bertaraf Q1 menuntut persyaratan yang ketat. Bahkan, seseorang yang telah memiliki kemampuan Bahasa Inggris yang baik masih harus melakukan revisi berkali-kali untuk memenuhi standar jurnal internasional bertaraf Q1. Buku “Sukses Menembus Jurnal Internasional Q1” ini membantu pembaca untuk mengatasi kebingungan yang dihadapi pada saat ingin memulai menulis artikel jurnal. Buku ini menginformasikan hal-hal penting yang perlu diketahui dan dipersiapkan oleh seorang akademisi maupun peneliti pemula sebelum mensubmit suatu naskah artikel ilmiah (manuscript) ke editor jurnal internasional bertaraf Q1. Buku ini juga dilengkapi berbagai tips mulai dari cara memilih jurnal Q1 hingga contoh penulisan masing-masing bab artikel jurnal yang meliputi judul, abstrak, pendahuluan, metode penelitian, hasil dan pembahasan, serta kesimpulan.
Isu Kontemporer Akuntansi Sektor Publik
Authors: Purwanti Lilik , Effendi Soelchan Arief
Published: May 2024

Isu Kontemporer Akuntansi Sektor Publik adalah salah satu mata kuliah program studi S1 akuntansi. Buku ini membahas Standar Akuntansi Pemerintahaan (SAP) berbasis akrual, sistem penganggaran dan sistem pengukuran serta pelaporan kinerja sektor publik, akuntansi berbagai lembaga sektor publik, diakhiri dengan akuntansi dan pengelolaan keuangan desa. Selain menjelaskan konsep isu akuntansi sektor publik, pada setiap akhir bab buku ini dilengkapi dengan ilustrasi latihan, kasus dan penyelesaiannya serta assesment pembelajaran yang dapat digunakan oleh mahasiswa untuk mengevaluasi pemahaman materi yang telah dibahas dalam bab tersebut. Buku Isu Kontemporer Akuntansi Sektor Publik dilengkapi dengan Team project yang merupakan kasus komplek yang harus diselesaikan oleh mahasiswa berdasarkan data riil di lapangan. Team project menghasilkan pengetahuan dan pengalaman terkait dengan softskill mahasiswa, seperti kerja sama dalam team dan kemampuan komunikasi baik secara lisan maupun tulisan. Selain itu melatih kemampuan dalam aspek kepemimpinan, etika perilaku, kemampuan analitis, kemampuan menyelesaikan masalah, dan respon terhadap situasi dinamis atau perubahan yang terjadi di lapangan. Berikut merupakan materi yang tercakup dalam buku ini.
Qual foi o destino do dinheiro do Fundo de Emancipação no pós-abolição? Projetos, protestos e disputas (1884-1890)
Authors: Cruz Itan
Published: May 2024

O objetivo deste artigo é contribuir para o debate público recente sobre a participação do Estado brasileiro e das instituições financeiras na escravidão de africanos e seus descendentes, apontando o destino das verbas que constituíram o fundo nacional de emancipação no imediato pós-abolição. Destacam-se projetos, protestos e disputas em relação ao dinheiro que, a princípio, tinha a finalidade de auxiliar os escravizados na conquista da sua liberdade e que, após o 13 de maio, colocou-se em contestação. Demostram-se as transformações pelas quais esse fundo passou desde a sua criação, em 1871, a implementação de uma taxa para sua ampliação, além de seguir o dinheiro, identificando beneficiários, onerados e ignorados. Foram consultados os anais da Câmara dos Deputados e do Senado do Império, assim como legislações, relatórios ministeriais, periódicos, charges, discursos e livros de época.
Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology
Authors: Kwartler Callie S. , Esparza Pinelo Jose Emiliano
Published: May 2024

The implementation of human induced pluripotent stem cell (hiPSC) models has introduced an additional tool for identifying molecular mechanisms of disease that complement animal models. Patient-derived or CRISPR/Cas9-edited induced pluripotent stem cells differentiated into smooth muscle cells (SMCs) have been leveraged to discover novel mechanisms, screen potential therapeutic strategies, and model in vivo development. The field has evolved over almost 15 years of research using hiPSC-SMCs and has made significant strides toward overcoming initial challenges such as the lineage specificity of SMC phenotypes. However, challenges both specific (eg, the lack of specific markers to thoroughly validate hiPSC-SMCs) and general (eg, a lack of transparency and consensus around methodology in the field) remain. In this review, we highlight the recent successes and remaining challenges of the hiPSC-SMC model.
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension
Authors: Tang Haiyang , Gupta Akash , Morrisroe Seth A. , Bao Changlei , Schwantes-An Tae-Hwi , Gupta Geetanjali , Liang Shuxin , Sun Yanan , Chu Aiai , Luo Ang , Ramamoorthi Elangovan Venkateswaran , Sangam Shreya , Shi Yinan , Naidu Samisubbu R. , Jheng Jia-Rong , Ciftci-Yilmaz Sultan , Warfel Noel A. , Hecker Louise , Mitra Sumegha , Coleman Anna W. , Lutz Katie A. , Pauciulo Michael W. , Lai Yen-Chun , Javaheri Ali , Dharmakumar Rohan , Wu Wen-Hui , Flaherty Daniel P. , Karnes Jason H. , Breuils-Bonnet Sandra , Boucherat Olivier , Bonnet Sebastien , Yuan Jason X.-J. , Jacobson Jeffrey R. , Duarte Julio D. , Nichols William C. , Garcia Joe G.N. , Desai Ankit A.
Published: May 2024

BACKGROUND:

The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin carboxyl-terminal hydrolase 1), a deubiquitinase, has been shown to reduce AKT1 (AKT serine/threonine kinase 1) degradation, resulting in higher levels. Given that AKT1 is pathological in pulmonary hypertension, we hypothesized that UCHL1 deficiency attenuates PAH development by means of reductions in AKT1.

METHODS:

Tissues from animal pulmonary hypertension models as well as human pulmonary artery endothelial cells from patients with PAH exhibited increased vascular UCHL1 staining and protein expression. Exposure to LDN57444, a UCHL1-specific inhibitor, reduced human pulmonary artery endothelial cell and smooth muscle cell proliferation. Across 3 preclinical PAH models, LDN57444-exposed animals,
Uchl1
knockout rats (
Uchl1
−/−
), and conditional
Uchl1
knockout mice (
Tie2Cre-Uchl1

fl/fl

) demonstrated reduced right ventricular hypertrophy, right ventricular systolic pressures, and obliterative vascular remodeling. Lungs and pulmonary artery endothelial cells isolated from
Uchl1
−/−
animals exhibited reduced total and activated Akt with increased ubiquitinated Akt levels. UCHL1-silenced human pulmonary artery endothelial cells displayed reduced lysine(K)63-linked and increased K48-linked AKT1 levels.

RESULTS:

Supporting experimental data, we found that rs9321, a variant in a GC-enriched region of the
UCHL1
gene, is associated with reduced methylation (n=5133), increased
UCHL1
gene expression in lungs (n=815), and reduced cardiac index in patients (n=796). In addition,
Gadd45α
(an established demethylating gene) knockout mice (
Gadd45α
−/−
) exhibited reduced lung vascular UCHL1 and AKT1 expression along with attenuated hypoxic pulmonary hypertension.

CONCLUSIONS:

Our findings suggest that UCHL1 deficiency results in PAH attenuation by means of reduced AKT1, highlighting a novel therapeutic pathway in PAH.
Direct Retrieval of Orthographic Representations in Chinese Handwritten Production: Evidence from a Dynamic Causal Modeling Study
Authors: He Jieying , Zhang Qingfang
Published: May 2024

This present study identified an optimal model representing the relationship between orthography and phonology in Chinese handwritten production using dynamic causal modeling, and further explored how this model was modulated by word frequency and syllable frequency. Each model contained five volumes of interest in the left hemisphere (angular gyrus [AG], inferior frontal gyrus [IFG], middle frontal gyrus [MFG], superior frontal gyrus [SFG], and supramarginal gyrus [SMG]), with the IFG as the driven input area. Results showed the superiority of a model in which both the MFG and the AG connected with the IFG, supporting the orthography autonomy hypothesis. Word frequency modulated the AG → SFG connection (information flow from the orthographic lexicon to the orthographic buffer), and syllable frequency affected the IFG → MFG connection (information transmission from the semantic system to the phonological lexicon). This study thus provides new insights into the connectivity architecture of neural substrates involved in writing.
An unusual new species of Melandrya Fabricius, 1801 (Coleoptera: Melandryidae) with new distributional notes for two additional Melandrya from Southwest China
Authors: YANG SHULIN , LIU JIE
Published: May 2024

An unusual Melandrya species with raised, pale yellowish-orange elytral spots like many species of Helotidae is described as Melandrya (s. str.) helotoides sp. nov. from Guizhou Province in southwest China. It is the ninth species of Melandrya from China. New distributional records are also provided for Melandrya (Bonzicus) incostata Fairmaire, 1889 and Melandrya (Bonzicus) coccinea (Lewis, 1895). All three species are reported from Leigongshan National Nature Reserve. The record for M. (B.) coccinea represents a new provincial occurrence for Guizhou Province. Habitus illustrations of the three species are provided.
Global Precipitation Experiment—A New World Climate Research Programme Lighthouse Activity
Authors: Zeng Xubin , Alves Lincoln , Boucher Marie-Amélie , Cherchi Annalisa , DeMott Charlotte , Dimri A. P. , Gettelman Andrew , Hanna Edward , Horinouchi Takeshi , Huang Jin , Lennard Chris , Leung L. Ruby , Luo Yali , Thamban Meloth , Palanisamy Hindumathi , Pryor Sara C. , Saint-Lu Marion , Sobolowski Stefan P. , Stammer Detlef , Steiner Jakob , Stevens Bjorn , Uhlenbrook Stefan , Wehner Michael , Zuidema Paquita
Published: May 2024

The future state of the global water cycle and the prediction of freshwater availability for humans around the world remain among the challenges of climate research and are relevant to several United Nations Sustainable Development Goals. The Global Precipitation Experiment (GPEX) takes on the challenge of improving the prediction of precipitation quantity, phase, timing, and intensity, characteristics that are products of a complex integrated system. It will achieve this by leveraging existing World Climate Research Programme (WCRP) activities and community capabilities in satellite, surface-based, and airborne observations, modeling, and experimental research and by conducting new and focused activities. It was launched in October 2023 as a WCRP Lighthouse Activity. Here, we present an overview of the GPEX Science Plan that articulates the primary science questions related to precipitation measurements, process understanding, model performance and improvements, and plans for capacity development. The central phase of GPEX is the WCRP Years of Precipitation for 2–3 years with coordinated global field campaigns focusing on different storm types (atmospheric rivers, mesoscale convective systems, monsoons, and tropical cyclones, among others) over different regions and seasons. Activities are planned over the three phases (before, during, and after the Years of Precipitation) spanning a decade. These include gridded data evaluation and development, advanced modeling, enhanced understanding of processes critical to precipitation, multiscale prediction of precipitation events across scales, and capacity development. These activities will be further developed as part of the GPEX Implementation Plan.