bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of asthma preventer dispensing for preventing childhood asthma readmissions: a multisite cohort linkage study
Authors: Chen Katherine Ya-Hui , Aye Tun Nilar , Jones Renee , Shanthikumar Shivanthan , Carlin John B , Hiscock Harriet
Published: April 2023

Objectives

To (1) describe the dispensing of asthma preventers at hospital discharge and estimate its effect on hospital readmissions, and (2) estimate the effect of community asthma preventer dispensing on readmissions for the subgroup of children who were not prescribed an asthma preventer at discharge.

Design

Multisite cohort study with linked administrative data.

Participants

Children aged 3–18 years admitted with asthma to a tertiary paediatric, mixed paediatric and adult, or regional hospital between 2017 and 2018.

Main outcome measure

Hospital readmission for asthma within 12 months.

Results

Of the 767 participants, 201 (26.2%) were newly prescribed or requested to continue with asthma preventers. Of these, only 91 (45.3%) dispensed their discharge prescription within 3 days or had an active prescription. There was no evidence for a protective effect of discharge asthma preventer dispensing on asthma hospital readmissions within 12 months (OR 1.17, 95% CI 0.69 to 1.97, p=0.57). Of the 566 children who were not prescribed asthma preventers at discharge, 269 (47.5%) had one or more prescriptions dispensed in the community within 12 months. Participants who were in the protected period (asthma preventer dispensed) had reduced risk of an asthma hospital readmission (HR 0.61, 95% CI 0.36 to 1.02, p=0.06), including preschool children (HR 0.48, 95% CI 0.25, 0.93, p=0.03) on subgroup analysis.

Conclusions

There was a low rate for prescribing and dispensing of hospital discharge asthma preventers and no protective effect was found for its impact on readmissions. A protective effect on readmissions was found for community asthma preventer dispensing.
Long-term follow-up of acute retinal necrosis with retinal detachment secondary to herpes simplex virus type 2 with a successful visual outcome
Authors: Sanjay Srinivasan , Sharief Shama , Joshi Aishwarya , Yadav Naresh Kumar
Published: April 2023

A man in his early 20s presented with acute loss of vision in his only eye, the left eye (OS), and was on oral steroids. He had lost vision in his right eye during his childhood and the cause was unknown. There was no history of trauma. Best-corrected visual acuity (BCVA) in OS was 20/100 and in the right eye was hand movements. OS showed non-granulomatous keratic precipitates on the cornea, anterior chamber flare 1+ and cell 1+, early cataract, vitreous haze and cells 2+ with nasal retinal detachment and superior full thickness retinitis. He underwent pars plana vitrectomy with intravitreal ganciclovir and barrage laser away from the necrotic retina. PCR for herpes simplex virus 2 was positive from the aqueous and vitreous sample. He was started on oral valacyclovir 1 g three times a day and continued on tapering dose of oral steroids. BCVA in OS at 6-month follow-up was 20/25.
How to set up a functional neurological disorder education group
Authors: Stanton Biba , Segal Tim , Bradley-Westguard Abigail , Edwards Mark
Published: April 2023

Functional neurological disorder (FND) can be a difficult diagnosis for patients to understand and for clinicians to explain. The postdiagnostic support that patients with other chronic neurological illnesses normally receive is often not available to patients with FND. Here, we share our experience of how to set up an FND education group, including the content, practical aspects of delivering groups and how to avoid potential pitfalls. A group education session can improve understanding of the diagnosis among patients and caregivers, reduce stigma and provide self-management advice. Such groups should be multidisciplinary and include input from service users.
New topic horizons for drone systems and applications
Authors: Anderson Karen , Shabaga Brandi M. , Wich Serge , Fink Geoff , Barczyk Martin , Hodgson Jarrod , Chabot Dominique
Published: April 2023

Summary

This journal (Drone Systems and Applications; DSA) conducted a targeted “horizon scan” during 2022 within our team of editors and associate editors. We asked— Which research areas currently under-represented in Drone Systems and Applications would you like to see more heavily represented in the future? The process highlighted five areas of interest and potential growth: Drones in the geosciences Aquatic drones Ground drones Drones within calibration/validation experiments Drones and computer vision

Over the past two years (2020–22), the journal has published over 50 papers with a strong leaning towards aerial drones for ecology and also with an engineering focus. DSA is keen to receive new submissions addressing the five highlighted areas, which lie firmly within the aims and scope of the journal. Further to the horizon scan, we propose two special collections for the coming year—one addressing drone applications ( drones in geoscience applications) and a second addressing drone systems ( aquatic drone systems). We would like to hear from scientists and practitioners in these fields as both contributors and (or) collection editors.
Analysis of localized CP asymmetry in $${\bar{B}}_{s}^{0} \rightarrow \pi ^+\pi ^-\pi ^{0}(K^{0})$$
Authors: Shi De-Sen , Lü Gang , Zhao Yan-Lin , Na-Wang  , Guo Xin-Heng
Published: April 2023

An investigation about localized CP asymmetries for the processes of $${\bar{B}}_{s}^{0} \rightarrow \pi ^{+}\pi ^{-}\pi ^{0} (K^{0})$$

B

¯

s

0

→

π
+

π
-

π
0

(

K
0

)

is presented in this paper. The innovation of this paper is that there is a consideration of three-particle $$\rho ^0(770)$$

ρ
0

(
770
)

, $$\omega (782)$$

ω
(
782
)

and $$\phi (1020)$$

ϕ
(
1020
)

interferences effect. Generally, $$\omega (782)$$

ω
(
782
)

and $$\phi (1020)$$

ϕ
(
1020
)

both can decay into $$\pi ^+\pi ^-$$

π
+

π
-

pair where can cause extremely small contribution from isospin symmetry breaking. Nevertheless, our analysis shows that $${\bar{B}}_{s}^{0} \rightarrow \pi ^+\pi ^-\pi ^{0}(K^{0})$$

B

¯

s

0

→

π
+

π
-

π
0

(

K
0

)

decay process can bring differential CP asymmetry about 65% (36%) because of isospin symmetry breaking. To be better compared with the data from experimental in the future, we integrate CP asymmetry over the invariant mass and obtain localized CP asymmetry value for the decay $${\bar{B}}_{s}^{0} \rightarrow \pi ^+\pi ^-\pi ^{0} (K^{0})$$

B

¯

s

0

→

π
+

π
-

π
0

(

K
0

)

. We find that there is an evident signal about CP asymmetry at invariant mass value $$m(\pi ^{+}\pi ^{-})$$

m
(

π
+

π
-

)

below the mass of $$\rho ^{0}(770)$$

ρ
0

(
770
)

with the decay $${\bar{B}}_{s}^{0} \rightarrow \pi ^+\pi ^{-}\pi ^{0}$$

B

¯

s

0

→

π
+

π
-

π
0

.
ℤ-local system cohomology of hyperplane arrangements and a Cohen–Dimca–Orlik type theorem
Authors: Sugawara Sakumi
Published: April 2023

Local system cohomology groups of the complements of hyperplane arrangements have played an important role in the theory of hypergeometric integrals, the topology of Milnor fibers and covering spaces. One of the important theorems is the vanishing theorem for generic [Formula: see text]-local systems which goes back to Aomoto’s work. Later, Cohen, Dimca, and Orlik proved a stronger version of the vanishing theorem. In this paper, we prove a Cohen–Dimca–Orlik type theorem for [Formula: see text]-local systems.
NUMERICAL STUDY OF THE FLUID DAMPER USED FOR EARTHQUAKE-RESISTANT REINFORCED STRUCTURES
Authors: TURKAN BURAK
Published: April 2023

In countries where the earthquake has devastating effects, new buildings should be earthquake-resistant. For this, soil surveys and structure natural vibration frequencies should be considered. In this study, regardless of the ground period, the fluid damper has been modeled numerically to decrease the natural vibration frequency of the structure. In fluid dampers, mechanical energy is converted into heat energy. The fluid damper was exposed to the same structure frequency value during an earthquake of 10, 20, 30, 40, 50, and 60[Formula: see text]s for four different building heights (6–12–18–24[Formula: see text]m) and the temperature and velocity distribution of the fluid damper was examined with the help of the COMSOL multiphysics. The temperature changes in the fluid damper for the 6[Formula: see text]m high building that has the lowest structure natural vibration period (highest frequency) were observed to be the highest. It has been determined that during the vibration, fluid passes through the micro channel between the piston and the outer surface of the fluid damper and reaches high temperatures and velocities because of the viscous heating effect.
Linking Mesoscopic and Macroscopic Aspects of Inclined Self-Weight Sandwich Beams with Functionally Graded Porous Cores Under Moving Loads
Authors: Chen Da , Rezaei Shahed , Yang Jie , Kitipornchai Sritawat , Zhang Lihai , Rosendahl Philipp L.
Published: April 2023

The surging interest in porous lightweight structures has been witnessed in recent years to pursue material innovations in broad engineering disciplines for sustainable developments and multifunctional proposes. Functionally graded (FG) porous composites represent a novel way to adjust mechanical characteristics by controlling the porosity distributions. However, the further advance in this field is challenged by the scale gap between mesoscopic and macroscopic aspects of porous structural analysis, i.e. how the local cellular morphologies impact the overall behaviors. The purpose of this paper is to bridge this gap by conducting a theoretical investigation on the performance of inclined self-weight sandwich beams with FG porous cores, where Young’s modulus is obtained with representative volume elements (RVEs) in a multiscale modeling study and depends on the cellular morphologies: average cell size and cell wall thickness. The material properties of closed-cell steel foams are adopted in a two-step assessment on target beams, including a static calculation to examine their bending deformations under gravitational loading which are then imported into a forced vibration analysis considering constant and harmonic moving forces. Timoshenko beam theory is used to establish the displacement field, while Ritz and Newmark methods are employed to solve the governing equations in terms of bending, free vibration, and forced vibration. The inclined beams are assumed to rest on a Pasternak foundation, and the corresponding structural responses can be determined based on the specific cell size and cell wall thickness, of which the effects are quantitatively revealed: the stiffness degradation induced from cellular morphologies increases the dynamic deflections, while the corresponding self-weight static deformations are reduced and the fundamental natural frequencies are raised. The influence from geometrical, boundary, and foundation conditions is also discussed to provide a comprehensive overview. This will be valuable for engineers to develop devisable foam-based load-carrying components with enhanced properties.
ANALYZING THE LONG-RUN AND SHORT-RUN IMPACTS OF CLIMATE CHANGE ON WHEAT AND MAIZE YIELD IN WESTERN HIMALAYAN REGION OF INDIA
Authors: CHOUDHARY TAHIR FAZAL , GUPTA MEENAKSHI
Published: April 2023

This study attempts to analyze the impact of climate change on the productivity of agricultural crops (wheat and maize), in the western Himalayan region of India for the period 1998–2019. The study implies second-generation panel estimation techniques. The Panel Autoregressive Distributed Lags (ARDL) method is used to analyze the long-and short-run effect of climatic variables i.e., average temperature, temperature range, and average precipitation on the yield of wheat and maize. The finding of the Panel ARDL shows that the average temperature of kharif season negatively affects the maize yield both in long run and short run, whereas the average temperature of rabi season has a negatively significant effect on wheat yield in long run and positively significant effect on wheat yield in short run. The average precipitation of rabi season has a positively significant effect on wheat yield both in long run and short run. The study recommends the development of advanced irrigation system, and the implementation of the insurance scheme by the Government and to adopt climate-smart farming techniques.
Anatomic Study of the Motor Branch of the Ulnar Nerve Regarding Carpal Tunnel Surgery: A Cadaveric Study
Authors: SIRIWITTAYAKORN Wuttipong , SAOSARN Parvaritpong , FONGSRI Warangkana , ATTHAKORN Wattanai
Published: April 2023

Background: Motor branch of the ulnar nerve (MUN) injury during carpal tunnel surgery is rare and it should never be injured during carpal tunnel release (CTR). However, an iatrogenic injury of the MUN can cause catastrophic physical and mental suffering. The aim of our study is to understand the anatomy of the MUN in relation to carpal tunnel in order to prevent iatrogenic injury during CTR.

Methods: We dissected 34 fresh cadaver hands and located the MUN in relation to the anatomical axis used for carpal tunnel surgery. Possible mechanisms of injury and the vulnerable area of the MUN were determined along the dissection.

Results: The MUN turned towards the thumb distal to hook of hamate. It then travelled on the floor of the carpal tunnel which was formed by intrinsic hand muscles under flexor tendons. The nerve located at 29.39 ± 7.41, 35.01 ± 3.14 and 38.79 ± 4.03 mm (Mean ± SD) in the central axis of ring finger, the vertical axis of the third web-space and the central axis of middle finger respectively. The nerve’s turning point, 10.9 ± 2.63 mm distal to the centre of hook of hamate where it lies just below the level of the transverse carpal ligament.

Conclusions: Surgeons should be aware of the nerve’s location. Surgical dissection or passing of any surgical instruments around the hook of hamate should be done with care.

Level of Evidence: Level IV (Therapeutic)
Surveying the Evidence on Sustainable Intensification Strategies for Smallholder Agricultural Systems
Authors: Jain Meha , Barrett Christopher B. , Solomon Divya , Ghezzi-Kopel Kate
Published: April 2023

Food demand is projected to increase significantly over the coming decades. Sustainable intensification (SI) is essential to meet this demand. SI is particularly important in smallholder systems, yet to date it remains unclear what the most promising SI strategies are to increase food production and farmer incomes at scale. We review the literature on SI to identify the most promising strategies, as manifest in replicated findings of favorable causal impacts. Adoption of improved cultivars generated the largest, most consistent, positive yield and economic outcomes. Two agroecological practices, push-pull systems and the System of Rice Intensification, also repeatedly led to large positive impacts. These strategies have considerable potential to scale to reach more than 50% of smallholder farmers who plant staple crops. Significant barriers to adoption remain, however, and identifying ways to overcome barriers to scale these successful strategies will be critical to meeting Sustainable Development Goals 1 and 2 by 2030.
Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging
Authors: Soto-Heredero Gonzalo , Gómez de las Heras Manuel M. , Escrig-Larena J. Ignacio , Mittelbrunn María
Published: April 2023

There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural killer properties, exhausted T cells with altered cytokine production, and regulatory T cells that gain proinflammatory features. Importantly, all of these subsets lose their lymph node homing capacity and migrate preferentially to nonlymphoid tissues, where they contribute to tissue deterioration and inflammaging.
Numerical Investigation on the Impact of Linear Variation of Positive Electrode Porosity upon the Performance of Lithium-Ion Batteries
Authors: Yu Runzhou , Li Peichao , Wang Keyong , Zhang Hengyun
Published: April 2023

The diffusion process of lithium-ions in the positive electrode solid phase as within the liquid phase is one of the pivotal factors in determining the battery performance. The effective conductivity and diffusion coefficient of the solid and liquid phases can be regulated by changing the distribution of the volume fraction of active material and porosity on the positive electrode. These crucial parameters can affect the transfer of lithium-ions in the solid and liquid phases and ultimately affect the battery’s performance. In this paper, a pseudo-three-dimensional (P3D) electrochemical-thermal-mechanical (ETM) coupling model is employed to study the non-uniform porosity of the positive electrode, especially the effect of porosity variation on the battery temperature and stress during the discharge process. Through numerical results, we find that reasonable porosity distribution can make the electrode lithiation more uniform and reduce the battery surface temperature by decreasing ionic ohmic heat. In addition, we display the stress distribution on the electrode and inside the active particles after adopting the linear porosity. The results are helpful for an in-depth understanding of the effect of the non-uniform porosity of the positive electrode on the lithium transport mechanism, the stress mechanism, and the thermal mechanism during the operation of lithium-ion batteries (LIBs).
Prediction Method of Vertical Ultimate Compressive Bearing Capacity of Single Pile in Soft Soil considering the Influence of Gravity
Authors: Xiao Kevin , Guo Shihong , Wen Jianghai , Han Jingbo , Yang Xiong
Published: April 2023

Considering that the pile foundation is widely used in soft soil, in order to improve the prediction accuracy of the vertical ultimate compressive bearing capacity of a single pile, this paper puts forward a calculation model of the pile side friction resistance in homogeneous soil based on the previous research and further deduces the calculation method of pile body internal force in layered soil under the influence of gravity field. In this research, the transmission of load along the pile body is related to the previous research on the ultimate end resistance, and an analytical calculation for the vertical ultimate compressive capacity of a single pile is proposed. The novelty of the method is that the ultimate bearing capacity is solved from the perspective of force transfer while considering its own gravity, making the results more accurate. In order to verify the reliability of the method, four engineering test piles in the soft soil area of Suzhou, China, were selected, and it is indicated that the results of the static load test and finite element simulation are consistent with the proposed method, proving that the method proposed in this paper for predicting the vertical ultimate compressive bearing capacity of single pile in soft soil area has an excellent effect.
RTP4, a Biomarker Associated with Diagnosing Pulmonary Tuberculosis and Pan-Cancer Analysis
Authors: Li Hao , Zhou Qin , Ding ZhiXiang , Wang QingHai
Published: April 2023

Background. Pulmonary tuberculosis (PTB) is a global epidemic of infectious disease; the purpose of our study was to explore new potential biomarkers for the diagnosis of pulmonary tuberculosis and to use the biomarkers for further pan-cancer analysis. Methods. Four microarray gene expression sets were downloaded from the GEO public databases and conducted for further analysis. Healthy control (HC) samples and samples of pulmonary tuberculosis (PTB) were calculated with enrichment scores in folate biosynthesis pathways. The scores acted as a new phenotype combined with clinical information (control or PTB) for subsequent analysis. Weight gene coexpression network analysis (WGCNA) was used to seek the modules mostly related to PTB and folate biosynthesis in training sets. Twenty-nine coexistence genes were screened by intersecting the genes in the green-yellow module of GSE28623 and the brown module of GSE83456. We used the protein-protein interaction network analysis to narrow the gene range to search for hub genes. Then, we downloaded the unified and standardized pan-cancer data set from the UCSC database for correlations between biomarkers and prognosis and tumor stage differences. Results. Eventually, RTP4 was selected as a biomarker. To verify the reliability of this biomarker, an area under the ROC (AUC) was calculated in gene sets (GSE28623, GSE83456, and GSE34608). Lastly, to explore the difference in RTP4 expression before and after antituberculosis treatment, the GSE31348 gene set was enrolled to compare the expressions in weeks 0 and 26. The results showed significant differences between these two time points (

p
<
0.001

). RTP4 was significantly upregulated in the pulmonary tuberculosis group compared to the healthy control group in three gene sets and downregulated after antituberculosis therapy in one gene set. These results suggest that RTP4 can be used as a potential biomarker in diagnosing tuberculosis. The results of pan-cancer analysis showed that high expression of RTP4 in 4 tumor types was positively correlated with poor prognosis and high expression of RTP4 in 6 tumor types was negatively correlated with poor prognosis. We found significant differences in the expression of the RTP4 gene at different stages in 5 types of tumors. Conclusion. RTP4 might be a new potential biomarker for diagnosing pulmonary tuberculosis.
A Miniaturized, Dual-Port, Multiband MIMO with CSRR DGS for Internet of Things Using WLAN Communication Standards
Authors: Roges Rashmi , Malik Praveen Kumar , Sharma Sandeep , Arora Sandeep Kumar , Maniraguha Fidele
Published: April 2023

A compact, dual-port, triband MIMO antenna is designed and tested for three sub-6 GHz WLAN bands for IoT applications. The size and performance of the antenna make it versatile for the emerging IoT applications communicating using the 2.4 GHz, 5.2 GHz, and 5.8 GHz WLAN frequencies. The single radiating element of antenna geometry includes a pair of modified and optimized rectangular patches. A complimentary split ring resonator (CSRR) structure is incorporated in the ground plane as a defect (defected ground structure) to attain the third operational band. The orientation of the elements, orthogonally arranged, along with DGS, enhances the isolation between the radiating elements keeping it below 18 dB throughout the three operating frequency bands. The size of the final antenna is as small as

0.32

λ

0

×
0.32

λ

0

 mm2 build on commercially available and cheap FR4 substrate of thickness 1.5748 mm. A peak gain of 7.17 dBi is attained for the proposed MIMO system. This MIMO antenna also satisfies the diversity parameter requirements including

DG
>
9.8

,

ECC
<
0.5

,

TARC
<
−
10

 dB, and

CCL
<
0.5

bits/s/Hz. This makes the proposed antenna a good candidate for IoT applications employing WLAN frequencies.
Monitoring and Maintenance of Highway Super-Large Bridge Based on BIM Technology
Authors: Zhang Yan , Dung Vinh Phuc
Published: April 2023

As the key node of highway traffic in China, the super-large bridge is the most important infrastructure of the country. With the completion of large-scale infrastructure construction in China, the key work of super-large bridges has changed from construction to maintenance. The service life of the super-large bridge is long, and with the increase of the service life of the super-large bridge, the annual maintenance cost is also increasing. At present, with the rapid development of super-large bridges in China, the diseases of super-large bridges are also increasing, and the maintenance and management of super-large bridges have become an urgent problem to be solved. In order to solve this problem, this paper takes the highway bridge as the research object and, on the basis of mastering the actual needs of the maintenance management of highway bridges in China, puts forward the monitoring and maintenance of bridges based on BIM technology, solves the lack of maintenance information elements in traditional BIM technology, studies the establishment method of the maintenance information model, finally develops the basic data acquisition software of the BIM model, accurately locates the disease position of the highway bridge, realizes the three-dimensional visual information management system of bridge, and continuously improves the maintenance efficiency. The research results show that starting from the monitoring and maintenance information management of highway bridges, the BIM data management method of the highway bridge maintenance stage is put forward, which realizes the visual management of maintenance information of highway bridges. Based on the analysis of the hierarchical information model of bridges, the component coding system of a bridge facing the maintenance management stage is established, and the visual management of diseases of bridges is put forward. Using BIM technology to assist the evaluation method of super-large bridges, using relational database and VBA project manager, based on the theoretical algorithm and interface design, automatic maintenance decision-making suggestions are realized. BIM technology is proposed to assist maintenance inspection and evaluation decision-making, and automatic and visual maintenance management of super-large bridges is realized. The research results provide practical guiding significance for further realizing the maintenance management system of highway bridges based on BIM technology.
Treatment of Liver Fibrosis after Hepatitis B with TCM Combined with NAs Evaluated by Noninvasive Diagnostic Methods: A Retrospective Study
Authors: Ying Li , Pan Zhou , Lin-Yi Zhu , Wan-Er Hong , De-He Wang , Zhen-Jie Zhang , Xi Chu , Yi-Qun Wang , Tian-Bai Shen , Wei Zhang
Published: April 2023

Objective. Chronic hepatitis B liver fibrosis is an important intermediate link in the development of liver cirrhosis. A retrospective cohort study was conducted in Longhua Hospital affiliated to the Shanghai University of Traditional Chinese Medicine in order to prove whether integrated traditional Chinese and Western medicine could improve the incidence of CHB complications and clinical prognosis. There are 130 patients with hepatitis B liver fibrosis (being treated from 2011–2021) included in the study, and the patients were divided into 64 TCM users (NAs combined with TCM) and 66 TCM nonusers (NAs antiviral therapy). The serum noninvasive diagnostic model (APRI, FIB‐4) and LSM value were used to classify the stages of fibrosis. The results showed that the LSM value was decreased significantly in TCM users compared with TCM nonusers (40.63% versus 28.79%). Indicators of FIB‐4 and APRI of TCM users have improved significantly compared with that of TCM nonusers (32.81% versus 10.61% and 35.94% versus 24.24%). The AST, TBIL, and HBsAg levels in TCM users were lower than those in TCM nonusers, and the HBsAg level was inversely correlated with the CD3+, CD4+, and CD8+ in TCM users. The PLT and spleen thickness of TCM users also were improved considerably. The incidence rate of end‐point events (decompensated cirrhosis/liver cancer) in TCM nonusers was higher than that of TCM users (16.67% versus 1.56%). The long course of the disease and a family history of hepatitis B were the risk factors for disease progression, and long‐term oral administration of TCM was the protective factor. As a result, the serum noninvasive fibrosis index and imaging parameters in TCM users were lower than those of TCM nonusers. Patients in the treatment of NAs combined with TCM had better prognoses such as a lower HBsAg level, a more stable lymphocyte function, and a lower incidence of end‐point events. The present findings suggest the effect of TCM combined with NAs in the treatment of chronic hepatitis B liver fibrosis is better than that of single drug treatment.
Measurable Versions of Some Topological Properties for Diffeomorphisms with Continuous Foliations
Authors: Wang Lin , Wang Xinsheng
Published: April 2023

In this paper, the concepts of plaque expansivity, topological quasi‐stability, and quasi‐shadowing property for Borel measures are considered. It is proved that every plaque expansive measure with the quasi‐shadowing property is topologically quasi‐stable with respect to its continuous foliation. At the same time, some other properties of the topological quasi‐stable measures, the plaque expansive measures, and measures with the quasi‐shadowing on a compact Riemannian manifold are investigated.
Human Resource Management Decision System University Based on Decision Model
Authors: Ma Shengqing , Liang Yinjing
Published: April 2023

The purpose of university personnel management is to improve the efficiency of running a school by optimizing the allocation of university human resources. Personnel management is one of the most important aspects of university administration, as it plays a key role in the formation of discipline teams and management teams. The use of advanced information technology is to improve the efficiency of personnel management, the establishment of university human resources analysis system, and to promote the school management work. Combining with the achievements of office automation and decision support development, this study analyzes the realization methods and key technologies of human resource management in university decision system, discusses the significance of human resource management in university decision system analysis based on decision model, and constructs human resource management in university decision system. This study first introduces the basic content of human resource management decision model and makes a comprehensive analysis of human resource demand prediction and then constructs a human resource management in university decision model according to the analysis structure. After defining the construction path of the decision‐making model of human resource management in colleges and universities, the human resource grading and promotion analysis is carried out to additionally define the prediction of human resource demand in universities. Finally, the decision system is realized and tested by means of mathematical model.
Flow Field and Pressure Loss Characteristics at Rotary Drillstring Joints
Authors: Nie Minghu , Ye Yuchen , Wang Zheng , Yuan Dandan , Wang Xingyi , Wei Kai
Published: April 2023

A thorough understanding and accurate calculation of the annulus pressure losses are paramount to drilling design and construction. However, due to the influence of the drillstring rotation and the abrupt dimensional variation at the joint, it is difficult to calculate the pressure loss by theoretical analysis in the annulus at the drillstring joints. Considering the geometric nonlinearity of drillstring joints and the unsteady flow of annular fluid caused by pipe rotation, based on the turbulence model

k
−
ε

, the flow field characteristics demonstrate the annulus pressure losses at the drillstring joint are studied by numerical simulation. Simulation results indicate that drillstring rotation speed, annular gap, and eccentricity greatly influence flow field and pressure losses at drillstring joints. The annular pressure loss would increase with the decrease of the annular gap and eccentricity but decrease with the increase of the drillstring rotation rate. The investigation method and results would help guide the design of drilling hydraulic parameters.
Protocol-Based Reliable Control for Power Systems with Communication Constraints
Authors: Chen Yong , Li Meng , Li Song , Wang Yunhui , Xie Min , Yang Yongkun
Published: April 2023

This study focuses on the protocol-based control for single-area power systems subject to actuator failures and deception attacks. Specifically, actuator failures, network attacks, unreliability, and bandwidth restrictions that emerge in power systems are taken into consideration at the same time. To cut down on the number of broadcast packets, a novel memory-adaptive event-triggered protocol is developed, where the trigger threshold parameter is adaptively changed in accordance with numerous historical sampled signals. Then, in virtue of the proposed algorithm, sufficient stabilization conditions are acquired to ensure the asymptotically stable of power systems with

H

∞

performance. Finally, the efficiency of the proposed control strategy is demonstrated by using a simulation example.
Presenting a Stochastic Model of Simultaneous Planning Problem of Distribution and Subtransmission Network Development considering the Reliability and Security Indicators
Authors: Moayed Seyed Hossein , Shahi Hosein Hasan , Akbarizadeh Mohammadreza , Jadidoleslam Morteza , Aghatehrani Arash , Pirouzi Afshin
Published: April 2023

Consumption growth demands power system expansion, and changes in a network lead to changes in operation indices of the upstream network. Hence, to establish a reliable planning of the distribution network, simultaneous planning of the subtransmission network should also be taken into account. It is predicted that this planning impacts different technical indices; therefore, formulation of various technical indices need to be included in the planning model. Therefore, in this study, the stochastic problem model of simultaneous planning of distribution and super distribution network development considering the reliability and security indicators is presented. The aforementioned problem is in the form of an optimization problem whose objective function is to minimize the costs of construction, replacement, operation, maintenance, reliability, and security. Furthermore, the mentioned problem is bound to the equations of power distribution, reliability, and security of voltage in addition to the limitation of network indicators. It is worth mentioning that, in the proposed problem, the active and reactive loads in addition to the operating price are in the form of uncertainty. Thus, the mentioned problem is in the form of a stochastic problem in which the point estimation method is used to evaluate the scenarios. Simultaneous expansion planning of distribution and subtransmission networks along with the placement of distributed generations and capacitors, as well as modeling security and reliability indices, is the novelty of the proposed scheme. In the end, the proposed problem is applied to the test network by GAMS optimization software, and then the capabilities of the proposed problem are extracted. Accordingly, based on numerical results, the expansion of distribution networks imposes considerable cost. Moreover, expansion planning of both distribution and subtransmission networks helps voltage to be in its permissible range, lower power loss, and improve reliability and security to 100%.
Mixed Maghemite/Hematite Iron Oxide Nanoparticles Synthesis for Lead and Arsenic Removal from Aqueous Solution
Authors: Moro Koua , Ello Aimé Serge , Koffi Konan Roger , Eroi N’goran Séverin
Published: April 2023

This work focused on the synthesis of iron oxide nanoparticles by the coprecipitation method with three basic solutions, namely, NH4OH, KOH, and NaOH. The synthesized iron oxides were characterized by various techniques such as XRD, MET, BET, and a SQUID magnetometer. The results showed nanosized particles of 13.2, 9.17, and 8.42 nm and different phases associated to maghemite and maghemite/hematite. The surface areas were 113, 94, and 84 m2/g and the magnetization strength were 58, 61, and 75 emu/g to iron oxides synthesized with NaOH, KOH, and NH4OH, respectively. The magnetic iron oxides obtained using NaOH were more efficient in the removal of lead and arsenic by adsorption than iron oxides obtained with KOH and NH4OH. However, the magnetic strength decreases using NaOH and KOH. The highest adsorption capacities attained for lead and arsenic removal were 16.6 and 14 mg/g, respectively, using NaOH-based iron oxides.
A Novel Method for Deflection Calculation of Reinforced Concrete Stair Slabs considering Step Stiffness
Authors: Peng Xiuzhong , Lu Chenhao
Published: April 2023

Stair slabs are some of the most common structural members with zigzag shapes in various buildings. However, the calculated deflection is usually overestimated during the design of stair slabs. In this article, the overestimated deflection is amended by utilizing step stiffness. To this end, it is assumed that the stress distribution of a unit cell in stair slabs is linear or bilinear under a constant bending moment. Stair slabs can be approximately regarded as flat slabs to derive the equivalent thickness based on the same bending strain energy. Subsequently, finite element (FE) models are established to verify that the obtained equivalent thickness can be applied to reinforced concrete (RC) stair slabs. To improve computational efficiency, the normalized models of stair slabs are adopted for further analysis. On this basis, a novel design method is proposed considering step stiffness for RC stair slabs. Furthermore, numerical examples are presented to compare the improved design method with the FE method and the conventional method. The results demonstrate that the design method considering step stiffness can not only ensure structural safety but also reduce concrete and steel consumption, making the design of stair slabs more economical and reasonable.
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats
Authors: Wang Jiayi , Lu Shunyi , Yuan Ya , Huang Lei , Bian Mengxuan , Yu Jieqin , Zou Jiapeng , Jiang Libo , Meng Dehua , Zhang Jian
Published: April 2023

Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases. However, the role of pyroptosis of Schwann cells in PNI remains unclear. Methods. We established a rat PNI model, and western blotting, transmission electron microscopy, and immunofluorescence staining were used to confirm pyroptosis of Schwann cells in PNI in vivo. In vitro, pyroptosis of Schwann cells was induced by lipopolysaccharides (LPS)+adenosine triphosphate disodium (ATP). An irreversible inhibitor of pyroptosis, acetyl (Ac)-Tyr-Val-Ala-Asp-chloromethyl ketone (Ac-YVAD-cmk), was used to attenuate Schwann cell pyroptosis. Moreover, the influence of pyroptotic Schwann cells on the function of dorsal root ganglion neurons (DRGns) was analyzed by a coculture system. Finally, the rat PNI model was intraperitoneally treated with Ac-YVAD-cmk to observe the effect of pyroptosis on nerve regeneration and motor function. Results. Schwann cell pyroptosis was notably observed in the injured sciatic nerve. LPS+ATP treatment effectively induced Schwann cell pyroptosis, which was largely attenuated by Ac-YVAD-cmk. Additionally, pyroptotic Schwann cells inhibited the function of DRGns by secreting inflammatory factors. A decrease in pyroptosis in Schwann cells promoted regeneration of the sciatic nerve and recovery of motor function in rats. Conclusion. Given the role of Schwann cell pyroptosis in PNI progression, inhibition of Schwann cell pyroptosis might be a potential therapeutic strategy for PNI in the future.
Forbidden Restrictions and the Existence of

P

≥
2

-Factor and

P

≥
3

-Factor
Authors: Wu Jianzhang , Yuan Jiabin , Baskonus Haci Mehmet , Gao Wei
Published: April 2023

The existence of factor and fractional factor in network graph in various settings has raised much attention from both mathematicians and computer scientists. It implies the availability of data transmission and network segmentation in certain special settings. In our paper, we consider

P

≥
2

-factor and

P

≥
3

-factor which are two special cases of general

H

-factor. Specifically, we study the existence of these two kinds of path factor when some subgraphs are forbidden, and several conclusions on the factor-deleted graph, factor critical-covered graph, and factor uniform graph are given with regards to network parameters. Furthermore, we show that these bounds are best in some sense.
Enfrentamiento de la anafilaxia en el servicio de urgencia
Authors: Peña Arturo , Carreño F. Fernando , Contreras Kissy , Balderrama Valeria , Miguel Alvarez Alonso
Published: April 2023

La anafilaxia es una reacción en su mayoría de hipersensibilidad tipo I, que estimula la activación generalizada de mastocitos, y provoca un cuadro clínico multisistémico que puede ser fatal. Se estima que tiene una incidencia de 0,03-0,1% y una prevalencia de vida de 0,5- 2% en la población general. Generalmente, la reacción inmunológica ocurre posterior a la ingesta de alimentos, uso de medicamentos o picaduras de insectos, pero también se han descrito mecanismos no inmunológicos (no IgE) que actúan directamente sobre los mastocitos, llamadas en la literatura “reacciones anafilactoideas”. La anafilaxia fue descrita por Paul Portier y Charles Robert Richet en 1902 en perros, los cuales desarrollaban esta reacción posterior a la inyección repetida de veneno de anémonas (medusas). Sin embargo, esta entidad no tuvo criterios diagnósticos ni pilares de manejo estructurado hasta el año 2006. En ese año en se publicó el segundo simposio de manejo de la anafilaxia, en donde se definieron criterios diagnósticos clínicos claros y el rol fundamental de la adrenalina en su manejo; la única droga que cambia el pronóstico del paciente.
Supplementary Material SM2 from Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial
Authors: Barlesi Fabrice , Tomasini Pascale , Karimi Maryam , Michiels Stefan , Raimbourg Judith , Daniel Catherine , Janicot Henri , Madroszyk Anne , Audigier-Valette Clarisse , Quoix Elisabeth , Mazieres Julien , Moro-Sibilot Denis , Dansin Eric , Molinier Olivier , Morel Hugues , Pichon Eric , Cortot Alexis , Otto Josiane , Chomy François , Souquet Pierre-Jean , Cloarec Nicolas , Giroux-Leprieur Etienne , Bieche Ivan , Lacroix Ludovic , Boyault Sandrine , Attignon Valery , Soubeyran Isabelle , Morel Alain , Tran-Dien Alicia , Jacquet Alexandra , Dall'Olio Filippo Gustavo , Jimenez Marta , Soria Jean-Charles , Besse Benjamin
Published: April 2023

Supplementary materials - substudy 2 statistical report
Data from Eganelisib, a First-in-Class PI3K-γ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
Authors: Hong David S. , Postow Michael , Chmielowski Bartosz , Sullivan Ryan , Patnaik Amita , Cohen Ezra E.W. , Shapiro Geoffrey , Steuer Conor , Gutierrez Martin , Yeckes-Rodin Heather , Ilaria Robert , O’Connell Brenda , Peng Joanna , Peng Guangbin , Zizlsperger Nora , Tolcher Anthony , Wolchok Jedd D.
Published: April 2023

Abstract
Purpose: Eganelisib (IPI-549) is a first-in-class, orally administered, highly selective phosphoinositide-3-kinase (PI3K)-γ inhibitor with anti-tumor activity alone and in combination with programmed cell death protein 1/ligand 1 (PD-1/PD-L1) inhibitors in preclinical studies. This phase 1/1b first-in-human, MAcrophage Reprogramming in Immuno-Oncology-1 (MARIO-1; NCT02637531) study evaluated the safety and tolerability of once-daily eganelisib as monotherapy and in combination with nivolumab in patients with solid tumors. Patients and Methods: Dose-escalation cohorts received eganelisib 10–60 mg as monotherapy (n=39) and 20–40 mg when combined with nivolumab (n=180). Primary endpoints included incidence of dose-limiting toxicities (DLTs) and adverse events (AEs). Results: The most common treatment-related grade ≥3 toxicities with monotherapy were increased alanine aminotransferase (ALT; 18%), aspartate aminotransferase (AST; 18%), and alkaline phosphatase (5%). No DLTs occurred in the first 28 days; however, toxicities meeting DLT criteria (mostly grade 3 reversible hepatic enzyme elevations) occurred with eganelisib 60 mg in later treatment cycles. In combination, the most common treatment-related grade ≥3 toxicities were increased AST (13%) and increased ALT and rash (10%). Treatment-related serious adverse events occurred in 5% of monotherapy patients (grade 4 bilirubin and hepatic enzyme increases in one patient each) and 13% in combination (pyrexia, rash, cytokine release syndrome, and infusion-related reaction in ≥2 patients each). Anti-tumor activity was observed in combination, including patients who had progressed on PD-1/PD-L1 inhibitors. Conclusions: Based on the observed safety profile, eganelisib doses of 30 mg and 40 mg once daily in combination with PD-1/PD-L1 inhibitors were chosen for phase 2 study.
Data from Frequent overexpression of HER3 in brain metastases from breast and lung cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie.
Published: April 2023

Abstract
Purpose: HER3 belongs to a family of receptor tyrosine kinases with oncogenic properties and is targeted by a variety of novel anticancer agents. There is a huge unmet medical need for systemic treatment options in patients with brain metastases (BM). Therefore, we aimed to investigate HER3 expression in BM of breast (BCa) and non-small cell lung (NSCLC) cancer as the basis for future clinical trial design. Experimental Design: We analyzed 180 BM samples of BCa or NSCLC and 47 corresponding NSCLC extracranial tissue. Immunohistochemistry was performed to evaluate protein expression of HER3, and immune cells based on CD3, CD8, and CD68. To identify dysregulated pathways based on differential DNA methylation patterns we used Infinium MethylationEPIC microarrays. Results: 99/132 (75.0%) of BCa-BM and 35/48 (72.9%) of NSCLC-BM presented with HER3 expression. Among BCa, HER2-positive and HER2-low BM showed significantly higher rates of HER3 co-expression than HER2-negative BM (87.1%/85.7% vs. 61.0%, p=0.004). Among NSCLC, HER3 was more abundantly expressed in BM than in matched extracranial samples (72.9% vs. 41.3%, p=0.003). No correlation of HER3 expression and intratumoral immune cell density was observed. HER3 expression did not correlate with overall survival from BM diagnosis. Methylation signatures differed according to HER3 status in BCa-BM samples. Pathway analysis revealed subtype specific differences, such as TrkB and Wnt signaling pathways dysregulated in HER2-positive and TNBC BM, respectively. Conclusions: HER3 is highly abundant in BM of BCa and NSCLC. Given the promising results of antibody-drug conjugates in extracranial disease, BM specific trials that target HER3 are warranted.