bluuebunny/crossref_metadata_2025 huggingface dataset:
Frequency, prognosis and predictors of improvement of systolic left ventricular function in patients with ‘classical’ clinical diagnosis of idiopathic dilated cardiomyopathy
Authors: Cicoira Mariantonietta , Zanolla Luisa , Latina Loredana , Rossi Andrea , Golia Giorgio , Brighetti Giovanna , Zardini Piero
Published: July 2002

In patients with dilated cardiomyopathy (DCM) of different aetiologies, a variable frequency of improvement in the left ventricular (LV) systolic function has been reported, while in patients with a ‘classic’ idiopathic DCM, the frequency of improvement is still under debate, and clinical and haemodynamic predictors of recovery of the LV function are needed. The aim of the present study was to determine the frequency of improvement in the LV systolic function in idiopathic DCM and to identify predictors of reversibility of the impaired LV contractility. A sample of 98 consecutive patients with idiopathic DCM was retrospectively evaluated. Echocardiographic and Doppler measurements were directly taken from the routine echo‐report. LV systolic function was assessed semiquantitatively using a score index (SFSI). According to the improvement in the LV systolic function, the patients were divided into group 1 patients with improvement, and group 2 patients without improvement. During a follow‐up of at least 12 months, 19 patients (19%) showed an improvement, with a significant increase in the mean SFSI; all these group 1 patients survived without heart transplant; in group 2, 18 patients (23%) died and 3 (4%) received a heart transplant. Patients in group 1 had a significantly shorter duration of symptoms (P ‐ 0.0045), a younger age (P ‐ 0.006), a shorter DtE (P ‐ 0.04), a lower SFSI (P < 0.01), a worse NYHA class (P < 0.001) and more frequently had a history of hypertension (P < 0.0001). The same variables were significant predictors of improvement at the univariate analysis. At the multivariate logistic regression analysis, a shorter duration of symptoms (P ‐ 0.02), a history of hypertension (P ‐ 0.003), and a worse NYHA class (P ‐ 0.01) were independent predictors of improvement. A relatively large percentage of patients with an idiopathic DCM will have a marked improvement in the LV systolic function. This is more likely to happen in the presence of a short duration of symptoms and a history of hypertension. After an improvement, the prognosis is excellent.
Nipple Pain in Breastfeeding Women: Causes, Treatment, and Prevention Strategies
Authors: Tait Priscilla
Published: July 2002

This article identifies problems and conditions that contribute to nipple pain during lactation and that may lead to early cessation or noninitiation of breastfeeding. Signs and symptoms of poor latch‐on and positioning, oral anomalies, and suckling disorders are reviewed. Diagnosis and treatment of infectious agents that may cause nipple pain are presented. Comfort measures for sore nipples and current treatment recommendations for nipple wound healing are discussed. Suggestions are made for incorporating in‐depth breastfeeding content into midwifery education programs.
Workplace measures against COVID-19 during the winter third wave in Japan: Company size-based differences
Authors: Ishimaru Tomohiro , Nagata Masako , Hino Ayako , Yamashita Satoshi , Tateishi Seiichiro , Tsuji Mayumi , Ogami Akira , Matsuda Shinya , Fujino Yoshihisa ,   CORoNaWork Project, Fujino Yoshihisa , Ogami Akira , Harada Arisa , Hino Ayako , Odgerel Chimed-Ochir , Ando Hajime , Eguchi Hisashi , Ikegami Kazunori , Muramatsu Keiji , Mori Koji , Kitagawa Kyoko , Nagata Masako , Tsuji Mayumi , Tanaka Rie , Matsugaki Ryutaro , Tateishi Seiishiro , Matsuda Shinya , Ishimaru Tomohiro , Nagata Tomohisa , Mafune Kosuke , Liu Ning
Published: May 2021

Objectives

Little is known about workplace measures against coronavirus disease 2019 (COVID-19) in Japan during the winter of 2020, especially in micro-, small-, and medium-sized enterprises (MSMEs). This study aimed to provide an overview of the current situation of anti-COVID-19 measures in Japanese enterprises during the winter, considering company size.

Methods

This study was an Internet-based nationwide cross-sectional study. Individuals who were registered as full-time workers were invited to participate in the survey. Data were collected using an online self-administered questionnaire in December 2020. The chi-squared test for trend was performed to calculate the P-value for trend for each workplace measure across company sizes.

Results

For the 27 036 participants, across company sizes, the most prevalent workplace measure was encouraging mask wearing at work, followed by requesting that employees refrain from going to work when ill and restricting work-related social gatherings and entertainment. These measures were implemented by approximately 90% of large-scale enterprises and by more than 40% of micro- and small-scale enterprises. In contrast, encouraging remote working was implemented by less than half of large-scale enterprises and by around 20% of micro- and small-scale enterprises. There were statistically significant differences in all workplace measures by company size (all P < .001).

Conclusions

We found that various responses to COVID-19 had been taken in workplaces. However, some measures, including remote working, were still not well-implemented, especially in smaller enterprises. The findings suggest that occupational health support for MSMEs is urgently needed to mitigate the current wave of COVID-19.
Enhancing Thermopower and Nernst Signal of High‐Mobility Dirac Carriers by Fermi Level Tuning in the Layered Magnet EuMnBi2
Authors: Tsuruda Keigo , Nakagawa Kento , Ochi Masayuki , Kuroki Kazuhiko , Tokunaga Masashi , Murakawa Hiroshi , Hanasaki Noriaki , Sakai Hideaki
Published: May 2021

Dirac/Weyl semimetals hosting linearly dispersing bands have received recent attention for potential thermoelectric applications, since their ultrahigh‐mobility carriers could generate large thermoelectric and Nernst power factors. To optimize these efficiencies, the Fermi energy needs to be chemically controlled in a wide range, which is generally difficult in bulk materials because of disorder effects from the substituted ions. Here it is shown that the Fermi energy is tunable across the Dirac point for layered magnet EuMnBi2 by partially substituting Gd3+ for Eu2+ in the insulating block layer, which dopes electrons into the Dirac fermion layer without degrading the mobility. Clear quantum oscillation observed even in the doped samples allows to quantitatively estimate the Fermi energy shift and optimize the power factor (exceeding 100 µW K−2 cm−1 at low temperatures) in combination with the first‐principles calculation. Furthermore, it is shown that Nernst signal steeply increases with decreasing carrier density beyond a simple theoretical prediction, which likely originates from the field‐induced gap reduction of the Dirac band due to the exchange interaction with the Eu moments. Thus, the magnetic block layer provides high controllability for the Dirac fermions in EuMnBi2, which would make this series of materials an appealing platform for novel transport phenomena.
Localized Delivery of Theranostic Nanoparticles and High‐Energy Photons using Microneedles‐on‐Bioelectronics
Authors: Lee Youngsik , Kang Taegyu , Cho Hye Rim , Lee Gil Ju , Park Ok Kyu , Kim Sangyeon , Lee Bowon , Kim Hyun Myung , Cha Gi Doo , Shin Yoonsoo , Lee Wanghee , Kim Minjeong , Kim Hyunjoong , Song Young Min , Choi Seung Hong , Hyeon Taeghwan , Kim Dae‐Hyeong
Published: May 2021

The low delivery efficiency of light‐responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood–brain barrier, has been a critical issue in NP‐based cancer treatments. Furthermore, high‐energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high‐energy photons to the target tumor using microneedles‐on‐bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light‐guiding/spreading microneedles deliver high‐energy photons from bioelectronics to the NPs. The high‐energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo‐drugs. The proposed method is demonstrated with mouse tumor models in vivo.
Ultrathin Modified Silica “Skin” for the Transfer Hydrogenation Catalyst: Improving Selectivity by Adjusting Surface Wettability
Authors: Guo Rongxiu , He Guangqi , Chen Xinyu , Zhang Xinyue , Hu Ze‐nan , Li Xiaodong , Niu Dun , Sun Hong‐bin
Published: May 2021

Surface wettability of heterogeneous catalysts plays a crucial role in the catalytic activity and selectivity. In this work, an ultra‐thin modified silica coating is firstly used as the “skin” to adjust the surface hydrophilicity of the catalyst, which promotes the catalytic activity and selectivity in the transfer hydrogenation of nitriles. The ultrathin‐modified silica “skin” with 2–3 nm thickness is fabricated by the consecutive hydrolysis of (3‐aminopropyl)triethoxysilane and n‐propyltriethoxysilane, and the bimetallic catalyst Fe3O4@PtCu is encapsulated in the coating. The modified catalyst demonstrated significant catalytic efficiency for hydrogenation of benzonitrile to dibenzylamine. The reaction performs 93% conversion and 99% selectivity in “green” solvent H2O. Furthermore, the modified silica “skin” encapsulates the PtCu nanoparticles to prevent the leaching of active sites, thus brings excellent catalytic recyclability. More than Fe3O4@PtCu, the modified silica “skin” is applicable to a diverse range of catalysts, that is, PtCu/SiO2, PtCu/Al2O3, and PtCu/UiO‐66, endowing them with additional catalytic activity and selectivity in the hydrogenation of nitriles.
Probing the Stochastic Dynamics of Coronaviruses: Machine Learning Assisted Deep Computational Insights with Exploitable Dimensions
Authors: Mukhopadhyay T. , Naskar S. , Gupta K. K. , Kumar R. , Dey S. , Adhikari S.
Published: May 2021

A machine learning assisted efficient, yet comprehensive characterization of the dynamics of coronaviruses, in conjunction with finite element (FE) approach, is presented. Without affecting the accuracy of prediction in low‐frequency vibration analysis, an equivalent model for the FE analysis is proposed, based on which the natural frequencies corresponding to first three non‐rigid modes are analyzed. To quantify the inherent system‐uncertainty efficiently, Monte Carlo simulation is proposed in conjunction with the machine learning based FE computational framework for obtaining complete probabilistic descriptions considering both individual and compound effect of stochasticity. A variance based sensitivity analysis is carried out to enumerate the relative significance of different material parameters corresponding to various constituting parts of the coronavirus structure. Using the modal characteristics like natural frequencies and mode shapes of the virus structure including their stochastic bounds, it is possible to readily identify coronaviruses by comparing the experimentally measured dynamic responses in terms of the peaks of frequency response function. Results from this first of its kind study on coronaviruses along with the proposed generic machine learning based approach will accelerate the detection of viruses and create efficient pathways toward future inventions leading to cure and containment in the field of virology.
Enhanced Locomotion of Shape Morphing Microrobots by Surface Coating
Authors: Ji Suchun , Li Xiying , Chen Qianying , Lv Pengyu , Duan Huiling
Published: May 2021

Mobile microrobots with shape morphing capability show great advantages for conducting tasks in complex environments. Combination of magnetically driven locomotion and stimuli‐responsive shape morphing is an effective strategy to realize these microrobots. However, most existing microrobots fabricated by the combination strategy are of low locomotion efficiency due to the limited amount of magnetic material loaded. Herein, a novel scheme for coating the magnetic nanoparticles (NPs) on the surface of microrobot is proposed to increase the magnetic material loading amount. Theoretical analyses demonstrate that, below a critical size at microscale, surface coating NPs can load more magnetic material than embedding NPs into the volume due to the high surface area‐to‐volume ratio. Microrobots with both shape morphing and enhanced magnetically driven locomotion are fabricated by coating magnetic NPs on the surface of stimuli‐responsive hydrogel microstructures. It is experimentally demonstrated that surface coating ensures that the microstructure has not only an efficient locomotion but also an excellent deformability. A four‐claw microgripper is fabricated, which is smaller and has higher magnetically driven locomotion speed than the most existing shape morphing microrobots. This microgripper demonstrating carrying and delivery capabilities is of immediate interest to microobject manipulation and minimally invasive surgery.
A Catalyst and Base Free Approach to Polycyclic Aromatic Compounds via Intramolecular [2+2] and retro‐[2+2] Cycloadditions
Authors: Lu Aoyun , Li Tao , Wang Jiayi , Song Gonghua
Published: May 2021

An efficient one‐pot strategy for the preparation of polycyclic aromatic compounds (PACs) has been developed. The catalyst and base free conditions, short reaction time under microwave irradiation, as well as the moderate to high yields of products, make the methodology more convenient and feasible. The mechanism study reveals that a novel cascade of thermal induced intramolecular [2+2] cycloaddition of bis‐N‐tosylhydrazones and retro‐[2+2] cycloaddition of 1,2‐diazetidines was involved in the reaction between biaryl dicarbonyl compounds and p‐tolylsulfonylhydrazine.
Septum submucosal glands exhibit aberrant morphology and reduced mucin production in chronic rhinosinusitis
Authors: Nnabue Onyekachi Ezinna , Pletcher Steven D. , Gurrola Jose G. , Goldberg Andrew N. , Jordan Kristiana M. , Knox Sarah M. , May Alison J.
Published: May 2021

Background

Chronic rhinosinusitis (CRS) is characterized by significant accumulation and thickening of mucus in the sinonasal cavities. One contributor of aberrant mucus production and impaired mucociliary clearance (MCC) is altered function of the sinonasal submucosal glands (SMGs), yet contributions of SMGs to upper airway disease initiation and progression remain unknown. The objective of this study was to characterize the morphology and secretory cell identities of the nasal septum SMGs in both healthy and CRS adults.

Methods

Biopsies from adult participants with CRS without nasal polyps (CRSsNP, n = 4), CRS with nasal polyps (CRSwNP, n = 8), and non‐CRS controls (n = 14) were collected from the posterior septum. Glandular morphology and mucus markers were investigated using histological techniques and high‐resolution confocal microscopy.

Results

Analysis revealed a significant decrease in gland density in the posterior septum of CRSsNP (28% ± 6.15%) and CRSwNP (23% ± 3.09%) compared to control participants (53% ± 1.59%, p < 0.0001). Further analysis of the CRS SMG secretory function revealed an overall decrease in Mucin 5B+ gland mucus being produced. Dilated and cystic ductal structures filled with inspissated mucus were also common to CRS glands.

Conclusion

Here, we describe a significant alteration in SMG structure and function in the adult CRS posterior septum suggesting reduced gland contribution to MCC. The SMGs of both the nose and sinuses may represent targets for future therapeutic approaches.
The implementation of reciprocal imitation training in a Part C early intervention setting: A stepped‐wedge pragmatic trial
Authors: Ibañez Lisa V. , Scott Sabine , Stone Wendy L.
Published: May 2021

Despite the development of several evidence‐based Naturalistic Developmental Behavioral Interventions (NDBIs), very few have been adapted for use in community‐based settings. This study examines the implementation of Reciprocal Imitation Training (RIT)—an NDBI—by community Early Intervention (EI; IDEA Part C) providers serving toddlers from birth to 3 years. Of the 87 EI providers enrolled from 9 agencies in 4 counties across Washington State, 66 were included in the current sample. A stepped‐wedge design was used to randomly assign counties to the timing of RIT training workshops. Self‐report measures of practice and self‐efficacy regarding ASD care were collected at baseline (T1, T2) and 6‐months and 12‐months post‐training (T3, T4). At T3 and T4, providers reported on RIT adoption and rated items about RIT feasibility and perceived RIT effectiveness; at T4, they also reported on child characteristics that led to RIT use and modifications. From pre‐training to post‐training, there were significant increases in providers' self‐efficacy in providing services to children with ASD or suspected ASD. At T3 and T4, provider ratings indicated high levels of RIT adoption, feasibility, and perceived RIT effectiveness. At T4, providers indicated that they most commonly: (a) initiated RIT when there were social‐communication or motor imitation delays, or an ASD diagnosis; and (b) made modifications to RIT by repeating elements, blending it with other therapies, and loosening its structure. While additional research is needed, RIT may help families get an early start on accessing specialized treatment within an established infrastructure available across the United States.

Lay Summary

Reciprocal imitation training (RIT) is an evidence‐based treatment for ASD that might be a good fit for use by intervention providers in widely accessible community‐based settings. After attending an educational workshop on RIT, providers reported feeling more comfortable providing services to families with ASD concerns, used RIT with over 400 families, and believed that RIT improved important social communication behaviors.
Intraventricular dysembryoplastic neuroepithelial tumor in the temporal horn with Broad involvement of the ependyma
Authors: Li Luying , Hu Xiao , Li Jingmei , Zhang Heng
Published: May 2021

Key Clinical Message

Though typical dysembryoplastic neuroepithelial tumors (DNETs) are located in the cerebral cortex, an atypical DNET could occur in the temporal horn of the lateral ventricle and broadly involve the ependyma. Awareness of this atypical form of DNET is of value for the wright diagnosis and management of atypical DNETs.
Therapeutic nihilism is inadequate in geriatric medicine
Authors: Nau Roland , Großmann Marius , Rohde Veit , Knopf Elmar , Dörges Joachim , Larsen Jörg
Published: May 2021

Patients' wishes should guide therapeutic considerations in the face of options and necessities, particularly when an intervention carries the risk of death. Therefore, in the medical management of the young and the old, everything should be attempted as long as the patient has a strong will to live.
Hydrogenation of CO2 to Methanol with Mn‐PNP‐Pincer Complexes in the Presence of Lewis Acids: the Formate Resting State Unleashed
Authors: Kuß David A. , Hölscher Markus , Leitner Walter
Published: May 2021

The hydrogenation of CO2 to methanol was achieved using a catalytic system comprising metal complexes of the form [Mn(CO)2[N(C2H4PR2)] (R=iPr/Ph, [HN(C2H4PPh2)2]=MACHO−Ph) together with Lewis acid additives. Mechanistic studies suggest initial CO2 insertion into a Mn−H bond leads to a formate complex as resting state. By systematically balancing the interaction between the acidic additive and the catalyst, the formate ligand could be removed through esterification to unleash the full catalytic potential. The reaction conditions were optimized on basis of the partial reaction order of relevant compounds. The combination of MACHO−Ph and Ti(OiPr)4 was identified as the most active system with a TON of 160 (p(CO2)=5 bar, p(H2)=160 bar, T=150 °C). Using methanol as solvent and co‐reagent allows the catalytic conversion of CO2/H2 in a liquid phase process comprising only the substrates and products.
Im heißen Bleikreislauf
Authors: Heidelberger Martin
Published: May 2021

Mit Hochtemperaturtechnologien werden elektrothermische Netzspeicher möglich, mit denen sich große Mengen Energie aus erneuerbaren Quellen puffern lassen. Im Verbundprojekt LIMELISA entwickeln das Karlsruher Institut für Technologie (KIT) und das Deutsche Zentrum für Luft und Raumfahrt (DLR) gemeinsam mit dem Industriepartner KSB die dafür notwendigen Grundlagen. Das Bundesministerium für Wirtschaft und Energie fördert die Forschung mit 3,8 Mio.
Einmotorige Schubzentrifuge
Authors: Pachta Nicole
Published: May 2021

Die neu entwickelte Schubzentrifuge ecoOne von Andritz ist für die Produktion von chemischen Grundprodukten, technischen Salzen und Agrochemikalien sowie Kunststoffen geeignet und behält die Verlässlichkeit und die Wascheffizienz der herkömmlichen Schubzentrifugen‐Technologie von Krauss‐Maffei bei, während Energieeffizienz, Flexibilität und Wartungsfreundlichkeit erhöht und dadurch die Betriebskosten und Stillstandszeiten gesenkt werden.
Abgestuftes Maßnahmenkonzept
Authors: Fricke Paul
Published: May 2021

Die Technische Regel für Gefahrstoffe (TRGS) 510 beschreibt die richtige Lagerung von Gefahrstoffen in beweglichen Behältern. Die überarbeitete Fassung birgt einige änderungen.
Nach der Auslösung
Authors: Frigger Anja
Published: May 2021

Im Explosionsfall empfängt die EXKOP Express Steuerung ein Auslösesignal, bspw. von dem Signalgeber einer flammenlosen Druckentlastung, von einer Berstscheibe, einem Drucksensor oder einem IR‐Flammenmelder. Dadurch aktiviert die Express Steuerung die ange
Effect of GLPG1205, a GPR84 Modulator, on CYP2C9, CYP2C19, and CYP1A2 Enzymes: In Vitro and Phase 1 Studies
Authors: Desrivot Julie , Van Kaem Tim , Allamassey Lisa , Helmer Eric
Published: May 2021

GLPG1205 is a novel agent being investigated for the treatment of idiopathic pulmonary fibrosis. GLPG1205 may be concomitantly administered with pirfenidone in future clinical development; therefore, the potential for GLPG1205 to interact with enzymes involved in the metabolism of pirfenidone (cytochrome P450 [CYP] 1A2, CYP2C9, 2C19) was evaluated. In vitro experiments indicated weak inhibition of CYP1A2 and moderate but reversible inhibition of CYP2C9 and CYP2C19 by GLPG1205. A phase 1 randomized, double‐blind crossover study in 14 healthy males (NCT02623296) evaluated the effect of GLPG1205 100 mg or placebo (once daily for 12 days) on the single‐dose pharmacokinetics of a cocktail of CYP1A2, CYP2C9, and CYP2C19 substrates (coadministered on day 13). GLPG1205 had no effect on the exposure of CYP2C9 and CYP1A2 substrates or metabolites; however, a trend toward increased omeprazole (CYP2C19 substrate) exposure was observed. Although considered not clinically relevant, GLPG1205 increased the elimination rate of 5‐hydroxyomeprazole (CYP2C19 metabolite) 1.16‐fold versus placebo. GLPG1205 had no effect on the elimination of all other substrates or metabolites. GLPG1205 had a favorable safety and tolerability profile. In conclusion, GLPG1205 100 mg once daily does not interact with CYP2C9, CYP2C19, or CYP1A2 to a clinically relevant extent and may be administered concomitantly with drugs metabolized by these enzymes.
DNA‐Compatible Click Reaction Employing In Situ Generated Azides from Boronic Acids
Authors: An Yulong , Yan Hao , Dong Zhenzhen , Satz Alexander L.
Published: May 2021

An efficient method for the synthesis of DNA‐conjugated 1,2,3‐triazoles is copper (II) [Cu(II)‐β‐cyclodextrin]‐mediated Huisgen cycloaddition (“click reaction”) of DNA‐conjugated alkynes with azides. However, a diverse array of building blocks is required to produce useful DNA encoded libraries, and the commercial availability of azides is limited. The method described herein generates azides in situ from aryl borates and TMSN3, which then further react with DNA‐conjugated terminal alkynes. © 2021 Wiley Periodicals LLC.

Basic Protocol 1: Conjugation of PEG linker to DNA headpiece

Basic Protocol 2: DNA conjugated terminal alkyne preparation

Basic Protocol 3: DNA compatible one‐pot click reaction

Basic Protocol 4: LCMS monitoring
LINC01133 promotes hepatocellular carcinoma progression by sponging miR‐199a‐5p and activating annexin A2
Authors: Yin Dan , Hu Zhi‐Qiang , Luo Chu‐Bin , Wang Xiao‐Yi , Xin Hao‐Yang , Sun Rong‐Qi , Wang Peng‐Cheng , Li Jia , Fan Jia , Zhou Zheng‐Jun , Zhou Jian , Zhou Shao‐Lai
Published: May 2021

Background

Long noncoding RNAs (lncRNAs) are functionally associated with cancer development and progression. Although gene copy number variation (CNV) is common in hepatocellular carcinoma (HCC), it is not known how CNV in lncRNAs affects HCC progression and recurrence. We aimed to identify a CNV‐related lncRNA involved in HCC progression and recurrence and illustrate its underlying mechanisms and prognostic value.

Methods

We analyzed the whole genome sequencing (WGS) data of matched cancerous and noncancerous liver samples from 49 patients with HCC to identify lncRNAs with CNV. The results were validated in another cohort of 238 paired HCC and nontumor samples by TaqMan copy number assay. We preformed Kaplan‐Meier analysis and log‐rank test to identify lncRNA CNV with prognostic value. We conducted loss‐ and gain‐of‐function studies to explore the biological functions of LINC01133 in vitro and in vivo. The competing endogenous RNAs (ceRNAs) mechanism was clarified by microRNA sequencing (miR‐seq), quantitative real‐time PCR (qRT‐PCR), western blot, and dual‐luciferase reporter assays. We confirmed the binding mechanism between lncRNA and protein by RNA pull‐down, RNA immunoprecipitation, qRT‐PCR, and western blot analyses.

Results

Genomic copy numbers of LINC01133 were increased in HCC, which were positively related with the elevated expression of LINC01133. Increased copy number of LINC01133 predicted the poor prognosis in HCC patients. LINC01133 overexpression in HCC cells promoted proliferation and aggressive phenotypes in vitro, and facilitated tumor growth and lung metastasis in vivo, whereas LINC01133 knockdown had the opposite effects. LINC01133 sponged miR‐199a‐5p, resulting in enhanced expression of SNAI1, which induced epithelial‐to‐mesenchymal transition (EMT) in HCC cells. In addition, LINC01133 interacted with Annexin A2 (ANXA2) to activate the ANXA2/STAT3 signaling pathway.

Conclusions

LINC01133 promotes HCC progression by sponging miR‐199a‐5p and interacting with ANXA2. LINC01133 CNV gain is predictive of poor prognosis in patients with HCC.
Yeast autonomously replicating sequence (ARS): Identification, function, and modification
Authors: Tan Xiao‐Yu , Wu Xiao‐Le , Han Ming‐Zhe , Wang Li , Xu Li , Li Bing‐Zhi , Yuan Ying‐Jin
Published: May 2021

Eukaryotic DNA replication begins with multiple origins of replication (ORIs) and thus exploring and identifying ORIs is essential for further understanding of the DNA replication process. In budding yeast, certain autonomously replicating sequences (ARSs) initiate the replication as ORIs, maintaining the stability of chromosomes and plasmids during genome replication. Currently, ARS identification was further facilitated by the DNA microarray technology and bioinformatics, which is based on the previous experimental methods. The structural and functional properties of ARSs on yeast chromosomes are gradually explored in this field. In addition to the function of initiating replication, there is a growing interest for researchers in the effects of ARSs on gene silencing and expression of genes, particularly the relationship between ARSs and chromosome structure. In this review, we summarized the identification methods of ARSs, especially for the bioinformatics prediction methods over the past few years. The functions of ARSs are discussed in this research, moreover, ARS modification that combined with the high‐throughput sequencing was elaborated as well, shedding further light on the understanding of the roles of ARSs, and providing deep insights towards the optimization of ARSs.
Performance and analysis of retail store‐centered microgrids with solar photovoltaic parking lot, cogeneration, and battery‐based hybrid systems
Authors: Shah Kunal K. , George Dane , Swan Lukas , Pearce Joshua M.
Published: May 2021

To examine the potential of distributed microgrids using sustainable energy sources centered on retail store parking lots, this study provides a methodology to simulate medium‐scale solar photovoltaic (PV) + combined heat and power (CHP) + battery hybrid microgrid systems deployed at big box retail stores. First, a method is provided to agglomerate 15‐min load data for a community of residences in the region of the store to provide baseline electricity load profiles. The systems are then modeled using dispatch strategies previously shown to be stable for smaller, but more dynamic loaded systems. The methodology is demonstrated with a case study for a Walmart Supercenter located in Nova Scotia, Canada. The electricity generated by each component of the hybrid system is coupled and optimized to fulfill the electric demands of the local community. The results provide the total electricity generated by the PV + CHP + battery hybrid system, total operating hours by each unit, fuel consumed, and hourly energy produced by each unit. The results show that such microgrid systems could serve the electrical needs of ˜1000 people (350 residences) for each parking lot of 3.5 MW PV system and CHP unit of 1 MW. The technical viability of this approach warrants future work.
Role ofSemisulcospira gottscheiextract as medicinal food on reflux esophagitis in rats
Authors: Nam Hyeon Hwa , Yang Sungyu , Kim Hyo Seon , Kim Min Jee , Kim Joong Sun , Lee Ji Hye
Published: May 2021

Gastroesophageal reflux disease (GERD) is a globally prevalent disease and results from a reflux of gastric contents into the esophagus. Existing synthetic drug‐based treatments for GERD have various drawbacks including refractory symptoms, relapse, or resistance due to long‐term use or may result in mucosal degeneration, polyps, and osteoporosis.Semisulcospira gottschei(SE), a freshwater snail, has been generally consumed as a food source due to its excellent flavor and nutritional value in Korea and considered to have therapeutic properties for various diseases including dyspepsia, stomachache, and hepatic diseases. The present study aims to investigate whetherSemisulcospira gottscheiextract (SGE) has a protective effect on reflux esophagitis‐induced rat models. The anti‐inflammatory effects of SGE were evaluated via NO production in LPS‐induced Raw 264.7 macrophage. And the protection effects of SGE were analyzed by assessing the amelioration of mucosal damage and expression of inflammation‐associated proteins in reflux esophagitis (RE) rats. Our results indicate that SGE significantly suppressed NO production in LPS‐induced raw 264.7 cells without any cytotoxicity. We observed mucosal lesions and histological changes in the esophagus of RE control rats. However, SGE treatment markedly ameliorated mucosal lesion ratio indicated through histological changes. SGE administration suppressed the expression of proteins related to inflammation, such as p‐NF‐κB, p‐IκBα, COX‐2, and TNF‐α, in esophageal tissue. Moreover, SGE elevated the expression of claudin‐5, which is a tight junction protein, involved in barrier function of epithelium and endothelium. The results suggest that SGE is useful as a medicinal food in esophagitis and may be helpful in developing effective treatment protocols for GERD.
Alterations of coagulation and fibrinolysis in patients with blunt splenic injury after splenic artery embolization
Authors: Ren Chuanzeng , Lu Huadong , Xia Honghai , Zhang Jia , Cao Bin , Wang Ying , Lu Dong , Cao Rongge
Published: May 2021

Background

Thrombotic complications following splenectomy have been documented. However, there has been sparse literature regarding thrombotic complications following splenic artery embolization (SAE).The objective of this study was to determine changes in coagulation and fibrinolysis and assess the thrombotic risk after SAE in patients with blunt splenic injury (BSI).

Methods

This study included 38 BSI patients who were hemodynamically stable on admission. SAE was performed if the splenic injury was classed as grade III or greater and had no requirement of immediate surgery. Platelet (PLT), fibrinogen (FIB), D‐dimers (D‐D), fibrinogen/fibrin degradation products (FDP), antithrombin III (AT III), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), hemoglobin (Hb), and hematocrit (Hct) were measured before SAE procedures and then 1d, 3d, and 7d after SAE.

Results

The technical success rate of SAE and the splenic salvage rate were 100%. There was no mortality. Compared with pre‐SAE values, the levels of PLT, FIB, D‐D, and FDP increased significantly at 3 days and 7 days after SAE (p < 0.05). However, AT III, PT, APTT, TT, Hb, and Hct showed no statistically significant difference at 1d, 3d, and 7d after SAE (p > 0.05).

Conclusion

Alterations in PLT and hemostatic parameters might contribute to the increased risk of thrombotic complications in BSI patients undergoing SAE. Thromboembolism following SAE should be considered and thrombotic prophylaxis should be recommended.
The establishment of auditory equivalence classes with a go/no‐go successive matching‐to‐sample procedure
Authors: Hanson Robbie J. , Miguel Caio F.
Published: May 2021

The go/no‐go successive matching‐to‐sample (S‐MTS) procedure involves the presentation of a sample followed by one comparison in the same location. Participants are required to either touch (go) or refrain from touching (no‐go) related and unrelated comparisons, respectively. One advantage of S‐MTS is that both sample and comparisons can be auditory. Thus, the purpose of Experiment 1 was to establish three 3‐member auditory equivalence classes using familiar dictated words. After training AB and AC relations, 16 out of 16 participants met emergence criterion for symmetry (BA/CA), 12 out of 16 for transitivity/equivalence (BC/CB), and 9 out of 16 for intraverbals, for which testing involved vocalizing relations among auditory stimuli. The purpose of Experiment 2 was to assess the potential influence of stimulus topography on equivalence class formation and the emergence of intraverbal behavior. After training AB and AC relations with unfamiliar stimuli, 16 out of 16 participants met emergence criterion for symmetry (BA/CA), 13 out of 16 for transitivity/equivalence (BC/CB), and 8 out of 16 for intraverbals. Results suggest that the S‐MTS procedure may serve as an alternative to simultaneous MTS in the development of auditory equivalence classes.
Diverse University Students Across the United States Reveal Promising Pathways to Hunter Recruitment and Retention
Authors: Vayer Victoria R. , Larson Lincoln R. , Peterson M. Nils , Lee Kangjae Jerry , Von Furstenberg Richard , Choi Daniel Y. , Stevenson Kathryn , Ahlers Adam A. , Anhalt‐Depies Christine , Bethke Taniya , Bruskotter Jeremy , Chizinski Christopher J. , Clark Brian , Dayer Ashley A. , Ghasemi Benjamin , Gigliotti Larry , Graefe Alan , Irwin Kris , Keith Samuel J. , Kelly Matt , Kyle Gerard , Metcalf Elizabeth , Morse Wayde , Needham Mark D. , Poudyal Neelam , Quartuch Michael , Rodriguez Shari , Romulo Chelsie , Sharp Ryan L. , Siemer William , Springer Matt , Stedman Richard , Stein Taylor , Van Deelen Tim , Whiting Jason , Winkler Richelle L. , Woosnam Kyle Maurice
Published: May 2021

Declining participation in hunting, especially among young adult hunters, affects the ability of state and federal agencies to achieve goals for wildlife management and decreases revenue for conservation. For wildlife agencies hoping to engage diverse audiences in hunter recruitment, retention, and reactivation (R3) efforts, university settings provide unique advantages: they contain millions of young adults who are developmentally primed to explore new activities, and they cultivate a social atmosphere where new identities can flourish. From 2018 to 2020, we surveyed 17,203 undergraduate students at public universities across 22 states in the United States to explore R3 potential on college campuses and assess key demographic, social, and cognitive correlates of past and intended future hunting behavior. After weighting to account for demographic differences between our sample and the larger student population, 29% of students across all states had hunted in the past. Students with previous hunting experience were likely to be white, male, from rural areas or hunting families, and pursuing degrees related to natural resources. When we grouped students into 1 of 4 categories with respect to hunting (i.e., non‐hunters [50%], potential hunters [22%], active hunters [26%], and lapsed hunters [3%]), comparisons revealed differences based on demographic attributes, beliefs, attitudes, and behaviors. Compared to active hunters, potential hunters were more likely to be females or racial and ethnic minorities, and less likely to experience social support for hunting. Potential hunters valued game meat and altruistic reasons for hunting, but they faced unique constraints due to lack of hunting knowledge and skills. Findings provide insights for marketing and programming designed to achieve R3 objectives with a focus on university students. © 2021 The Wildlife Society.
American Black Duck Nesting Ecology in North Carolina
Authors: Lawson Daniel M. , Williams Christopher K. , Howell Douglas L. , Fuller Joseph C.
Published: May 2021

North Carolina, USA, is the southernmost extent of the American black duck's (Anas rubripes) breeding range; however, little is known about their nesting ecology in this region. We located and monitored 140 nesting black ducks over 2 years (2017–2018) to quantify preferred nesting habitat and assess nesting productivity within coastal North Carolina. We located nests in brackish marshes (75%) and man‐made dredge spoil islands (25%) at a density of 1 nest/22 ha. Black ducks selected high marsh and nested an average of 21.81 m from open water at a mean elevation of 1.36 m. In preferred nesting habitat, visual obstruction readings were 0.50 m with a maximum mean vegetation height of 0.81 m and land cover consisted largely of grasses (84.6%). Apparent nest success rates varied from 31% (2017) to 63% (2018) across years. The majority (72.2%) of variability in nest success was best predicted by nest location (mainland marsh, natural island, or spoil island), vegetation density, maximum vegetation height, and year. Management for breeding black ducks in coastal North Carolina should focus on promoting selected nesting habitat and reducing nest predators. Prescribed burns, used to set back succession on spoil islands and in brackish marshes should be conducted in the winter or in the early growing season not to exceed the twenty‐fifth quantile date of black duck nest initiation (2 Apr). © 2021 The Wildlife Society.
Fostering knowledge sharing in the innovation process: Information and communication technology‐based versus face‐to‐face relationships
Authors: Ceci Federica , Lazoi Mariangela , Lezzi Marianna , Mohammad Heba
Published: May 2021

The paper investigates information and communication technology (ICT)‐based and face‐to‐face interactions for knowledge sharing during the activities characterizing the innovation process rather than strategic or operative ones. It also discussed the benefits of working remotely in companies or in a network of companies, also due to the pandemic situation such as the one we are experiencing today. The research design is based on the exploitation of a case study in the aerospace sector. Qualitative data are collected with interviews, and a content analysis is applied for extracting data useful for exploring different kind of relationships. Three significant results are described about the role of face‐to‐face interactions in knowledge sharing; the interaction through ICT tools for communication; and the different types of support provided by ICT tools. The paper extends the state of the art with new evidence in the field of knowledge sharing and conversion for sustaining the innovation process. The findings are original since new insights for the analysis of relationships are provided. Furthermore, the research methodology is described in detail and can introduce managers and scientists in content analysis applications also for industrial exploitation.
Office‐Based Removal of Vocal Fold Polyp During the COVID‐19 Pandemic
Authors: Cukic Ognjen
Published: May 2021

View Video S1 Laryngoscope, 132:103–106, 2022
Introducing a data availability policy for journals at IOP Publishing: Measuring the impact on authors and editorial teams
Authors: Holt Jade , Walker Andrew , Jones Phill
Published: May 2021

As the open research movement continues to gather pace, a number of publishers, funders, and institutions are mandating the sharing of underlying research data. At the same time, concerns about introducing extra quality control steps around data availability statements (DAS) are driving a discussion about the best way to make data more open without slowing down publication. This article describes a pilot project to introduce a new Open Data policy to three IOP Publishing (IOPP) journals as part of IOPP's commitment to increasing transparency and support for open science. An investigation was undertaken using an automated workflow monitoring tool to understand the impact of this change on authors and the editorial staff. Changes in revised submission processing times and how often manuscripts were returned to the author were measured. An overall increase in the time editorial staff spent processing manuscripts was found as well as an increase in the number of times manuscripts were returned to authors. Detailed analysis shows that manuscripts in which authors claim in the DAS to have included data within the manuscript were the most strongly affected. Steps to mitigate the effects through improved author communication were found to be effective.
Segmented simultaneous multi‐slice diffusion‐weighted imaging with navigated 3D rigid motion correction
Authors: Riedel (né Steinhoff) Malte , Setsompop Kawin , Mertins Alfred , Börnert Peter
Published: May 2021

Purpose

To improve the robustness of diffusion‐weighted imaging (DWI) data acquired with segmented simultaneous multi‐slice (SMS) echo‐planar imaging (EPI) against in‐plane and through‐plane rigid motion.

Theory and Methods

The proposed algorithm incorporates a 3D rigid motion correction and wavelet denoising into the image reconstruction of segmented SMS‐EPI diffusion data. Low‐resolution navigators are used to estimate shot‐specific diffusion phase corruptions and 3D rigid motion parameters through SMS‐to‐volume registration. The shot‐wise rigid motion and phase parameters are integrated into a SENSE‐based full‐volume reconstruction for each diffusion direction. The algorithm is compared to a navigated SMS reconstruction without gross motion correction in simulations and in vivo studies with four‐fold interleaved 3‐SMS diffusion tensor acquisitions.

Results

Simulations demonstrate high fidelity was achieved in the SMS‐to‐volume registration, with submillimeter registration errors and improved image reconstruction quality. In vivo experiments validate successful artifact reduction in 3D motion‐compromised in vivo scans with a temporal motion resolution of approximately 0.3 s.

Conclusion

This work demonstrates the feasibility of retrospective 3D rigid motion correction from shot navigators for segmented SMS DWI.
A model‐based framework for correcting inhomogeneity effects in magnetization transfer saturation and inhomogeneous magnetization transfer saturation maps
Authors: Rowley Christopher D. , Campbell Jennifer S. W. , Wu Zhe , Leppert Ilana R. , Rudko David A. , Pike Gilbert Bruce , Tardif Christine L.
Published: May 2021

Purpose

In this work, we propose that Δ‐induced errors in magnetization transfer (MT) saturation (MTsat) maps can be corrected with use of an R1 and map and through numerical simulations of the sequence.

Theory and Methods

One healthy subject was scanned at 3.0T using a partial quantitative MT protocol to estimate the relationship between observed R1 (R1,obs) and apparent bound pool size () in the brain. MTsat values were simulated for a range of , R1,obs, and . An equation was fit to the simulated MTsat, then a linear relationship between R1,obs and was generated. These results were used to generate correction factor maps for the MTsat acquired from single‐point data. The proposed correction was compared to an empirical correction factor with different MT‐preparation schemes.

Results

was highly correlated with R1,obs (r > 0.96), permitting the use of R1,obs to estimate for correction. All corrected MTsat maps displayed a decreased correlation with compared to uncorrected MTsat and MTsat corrected with an empirical factor in the corpus callosum. There was good agreement between the proposed approach and the empirical correction with radiofrequency saturation at 2 kHz, with larger deviations seen when using saturation pulses further off‐resonance and in inhomogeneous (ih) MTsat maps.

Conclusion

The proposed correction decreases the dependence of MTsat on inhomogeneities. Furthermore, this flexible framework permits the use of different saturation protocols, making it useful for correcting inhomogeneities in ihMT.
An innovative operation‐time‐space network for solving different logistic problems with capacity and time constraints
Authors: Ambrosino Daniela , Asta Veronica
Published: May 2021

This work describes an innovative operation‐time‐space network that can be easily adapted to model different logistic problems involving time and space decisions. In the recent literature, different time‐space networks have been proposed to deal with specific requirements of problems arising in the logistic and transportation fields. The proposed network is able to deal with different types of capacity and time constraints that characterized the most part of logistic problems. The article explains how to construct the operation‐time‐space network, how to model time and capacity constraints of different types; moreover, it presents an application of this network to solve a logistic problem arising in the rail‐sea exchange node, that is the scheduling of port rail shunting operations. Other applications are briefly introduced. Finally, the well‐known quay crane scheduling problem is modeled, thanks to the operation‐time‐space network; the related flow model is tested by using a benchmark suite available in the literature.
Influence of solvent, Lewis acid–base complex, and nanoparticles on the morphology and gas separation properties of polysulfone membranes
Authors: Maghami Saeid , Sadeghi Morteza , Baghersad Samaneh , Zornoza Beatriz
Published: May 2021

A series of polysulfone (PSF) membranes were prepared using different solvents: dimethylformamide (DMF), tetrahydrofuran, dimethylacetamide, and n‐methyl‐2‐pyrrolidone (NMP). The PSF membrane prepared by NMP showed the highest gas permeability. The influence of propionic acid as a Lewis acid on gas separation properties of the PSF was explored. The PSF membrane prepared by the casting solution containing 25 wt% PSF, 35 wt% propionic acid, and 40 wt% NMP showed a superior gas separation performance. The gas permeation measurements indicated that incorporating 30 wt% γ‐alumina nanoparticles into the PSF matrix resulted in about the respective 43% and 41% increase in CO2 and O2 permeability together with a rise in CO2/CH4 and O2/N2 selectivities (13% and 7%, respectively). Furthermore, by rearranged modified Maxwell model, the role and nature of the interfacial layer in the PSF‐based mixed matrix membranes were mathematically analyzed considering a reduced permeability factor.