bluuebunny/crossref_metadata_2025 huggingface dataset:
“A Perceptive Review on Advancement in Drug Delivery System”.
Authors: Shaikh Sahil , Satpute, Rohit , Satpute Ankita , Omkar Shelke , Pawar Mr.Vijay
Published: December 2024

Drug targeting to specific organs and tissues has
become one of the critical endeavors of the century
since the use of free drugs in conventional dosage
forms generally involves difficulties in achieving
the target site at the appropriate dose after or during
a proper time period. Recent drug delivery systems
(DDS) are formulated using advanced technology
to accelerate systemic drug delivery to the specific
target site, maximizing therapeutic efficacy and
minimizing off-target accumulation in the body. As
a result, they play an important role in disease
management and treatment. This review explores
the dynamic landscape of drug delivery systems,
focusing on their profound impact on therapeutic
efficacy and patient compliance. The integration of
nanotechnology, RNA therapeutics, implantable
devices, 3D printing, and artificial intelligence
heralds a transformative era in precision medicine.
Nanoparticles enable precise targeting, while RNA
therapeutics offer molecular-level interventions.
Implantable and injectable devices promise
sustained release, enhancing patient compliance.
3D printing introduces personalized dosage forms,
and artificial intelligence empowers data-driven
adjustments to treatment plan.
Prescription Auditing in Outpatient Departments of Associated Hospitals of Government Medical College Anantnag
Authors: Dr.Nasreen Jan Dr.Nasreen Jan , Ruhail Dr.Raja , Nabi Dr.Masrat , Magray Dr.Sami , Hanan Dr.Sheikh , Jabeen Dr.Asra , Rafi. Dr.Rehab
Published: December 2024

Background: A prescription audit is a quality
improvement tool for ensuring the rational use of
drugs and is based on documented evidence of
diagnosis, treatment, and instructions to achieve the
same. A periodic prescription audit is required to
identify common deficiencies in prescriptions and
to undertake corrective measures to improve
prescribing practices. In this study, we aim to
understand the prescription practices and identify
the bottlenecks and opportunities for improvement
and prescribing behavior of physicians using the
WHO-recommended core prescribing indicators
and the National Health Mission proposed
additional indicators at a teaching hospital.
Methods: A Prospective, Observational study is
going on in outpatient departments of a tertiary care
hospital of GMC Anantnag and we present the data
in this study of the initial two years of the audit. A
total 1125 prescriptions were audited on the
checklist formulated by NHM as per standard
auditing parameters. 17 parameters were evaluated.
Prescriptions collected from OPDs of various
clinical departments were analyzed in the
department of pharmacology. RESULTS: The
audit revealed that the average number of
antibiotics prescribed was 26.8%in 2021& 7.5% in
2022and only 19.67% in 2021&0.3%in 2022 of the
drugs were prescribed by generic name. Whereas,
the percentage of prescriptions duly signed was
15.5%&12%in 2021and 2022 respectively and the
prescription of injectables was 27% in
2021&12.6%in 2022 which was less than the ideal
recommendations as per WHO, and 1265 (88%) of
the drugs were prescribed from the National List of
Essential Medicines Prescription auditing gives a
current scenario of prescribing practices in a
tertiary care hospital setting. Conclusion: This
prospective observational study points towards the
great need for improvement in prescribing patterns
in areas of antibiotic prescribing, generic names,
dose, and dosage forms, thus reducing the practice
of polypharmacy. Through a comprehensive review
of relevant literature, coupled with empirical data
collection and analysis, this endeavors to shed
light on the role of prescription auditing as a
proactive measure in promoting rational prescribing
habits and mitigating potential risks associated with
medication use.
A Comprehensive Review of Hemigraphis Alternata
Authors: S.Gowthaman S.Gowthaman , Dr.K.B.Ilango Dr.K.B.Ilango , Brindha.R Brindha.R , Bharathi.S Bharathi.S , Paulraj.W Prince , Aju.N.T Aju.N.T , Yadukrishnan.T Yadukrishnan.T
Published: December 2024

Hemigraphis alternata, commonly
known as Red Flame Ivy or Purple Waffle Plant, is
a perennial herb native to Malaysia that is widely
cultivated in tropical regions1. Traditionally, it has
been used for wound healing and treating various
ailments. Its leaves contain bioactive compounds
such as flavonoids, alkaloids and phenols. Recent
studies have highlighted its antioxidant,
antibacterial and anti-inflammatory properties. The
plant grows in warm and humid environments and
is highly valued for its ornamental effects. In this
review, we investigate its phytochemical
composition, traditional uses, and pharmacological
activity and highlight its potential in modern
medicine
Studies on the Impact of Date Stone and Cinnamon on the Caffeine Content of Coffee
Authors: Durrani Nikhat Khatun , Bornare Dr. Deepak , Aitwar Shivkanya
Published: December 2024

This study investigated the impact of date stone
and cinnamon on the caffeine content of coffee.
Date seeds, often discarded, are rich in essential
minerals and dietary fibers, providing numerous
health benefits. The research involved creating
coffee blends with various proportions of date
stone powder, Nescafe Classic coffee, and Ceylon
cinnamon. These blends were analyzed for
nutritional composition, sensory properties,
caffeine content, and shelf life. The optimal blend,
containing 55% date stone powder, 2% cinnamon,
and 43% Nescafe Classic, resulted in a significant
55.5% reduction in caffeine content compared to
traditional coffee. Sensory evaluation indicated the
high acceptability of this blend. The study
demonstrated that date stone coffee could serve as
a nutritious, sustainable alternative to conventional
coffee, addressing concerns related to excessive
caffeine intake while enhancing flavor and
nutritional value with the addition of cinnamon.
A review article on Ophthalmic Preparation by Using Transitional Metal Complex Synthesised from Hedychium Coronarium Leaf for the treatment of Diabetic Cataract
Authors: Singh Yadav Jitendra , Sharma1 Vikas Chandra
Published: December 2024

Diabetes cataract is one the most common
endocrinological disorder which is globally
affecting a large number of the persons.
Uncontrolled diabetes may trigger secondary
delirious complications affecting the kidneys, eyes,
cardiovascular system and central nervous system.
Elevated blood glucose level causes detrimental
secondary ocular complications like diabetic
cataract, diabetic retinopathy, diabetic
keratanopathy, diabetic glaucoma and diabetic
papillopathy. In this work we evaluated the role of
the nicotine exacerbation on the diabetic cataract
and evaluated the pharmacological approach in
management of the diabetic cataract using
transitional metal coordination complex.
The extensive literature survey was done to find
suitable candidates for the ligand and metal ion for
the metal coordination synthesis which not only
manage the diabetes but also improves the damage
done to the lens due to cataract caused by diabetic
cataract.
The rationale behind selecting the transitional as
metal ion for the complex was the insulinomimetic
effect of transitional metal salts and NSAID was
selected because of the previous reported beneficial
effects of NSAID against diabetic complications
due to reduction in oxidative stress as well as in
inflammatory mediators like interleukins. The
complex was synthesized using as metal ion and
NSAID as the ligand. The synthesized complex
was evaluated for physiochemical properties and
structural confirmation. The current work also
explore the role of ophthalmic drug delivery system
effect against diabetic cataract, to design a system
with maximum effect and minimum obnoxious
effects.
Parenteral Preparation and Parenteral Routes of Administration: A Review of Parenteral Medications
Authors: Bhalerao Prof. Pratibha , Gulave Deep Prakash , Jadhav Balaji Suresh , Navnath Jangle Mayuri
Published: December 2024

Parenteral administration refers to the direct
injection of medications into the body, bypassing
the digestive system. This route is critical for drugs
that require rapid onset of action, precise dosage, or
are poorly absorbed orally. Parenteral products
must be sterile and free of contaminants, as they
are administered via injections into internal body
compartments. The term "parenteral" originates
from Greek, meaning "outside the intestine,"
emphasizing the unique nature of this drug delivery
method.
The advantages of parenteral administration
include immediate clinical response in
emergencies, suitability for patients who cannot
swallow, and the potential for prolonged drug
absorption through intramuscular routes. However,
it also presents disadvantages such as the
irreversibility of intoxication, the risk of local
irritation, high production costs, and the potential
for unauthorized administration.
Various routes of parenteral administration include
intravenous, intramuscular, subcutaneous,
intradermal, intraosseous, intra-articular, and
intraocular. Each method has specific applications,
advantages, and disadvantages. For instance,
intravenous (IV) administration offers rapid effects
and full bioavailability, while intramuscular (IM)
injections allow for larger volumes but may cause
discomfort. Subcutaneous (SC) injections are easier
to self-administer but are limited to smaller
volumes.
The development of parenteral formulations
requires careful consideration of stability, sterility,
osmolarity, pH, and excipient compatibility, all
adhering to regulatory standards from agencies like
the FDA and EMA. Quality control tests are
essential to ensure the safety and efficacy of
parenteral products, including sterility, pyrogen,
pH, particulate matter, potency, stability, container
integrity, endotoxin, clarity, and microbial limits
testing.
Parenteral formulations can include solutions,
suspensions, emulsions, lyophilized products, and
depot formulations, each tailored for specific
therapeutic needs. The careful design and rigorous
testing of these formulations are vital to prevent
complications and ensure optimal therapeutic
outcomes for patients. This comprehensive
overview highlights the importance of parenteral
administration in modern medicine, underscoring
its complexity and necessity in delivering effective
treatment options.
Knowledge, Attitude and Practices of Materiovigilance among the Medical Students and Non-Medical People: A Cross-Sectional Study
Authors: Tyagi Vishvanshi , Baghel Vinay , Kumari Raj
Published: December 2024

Background: Post-market
surveillance plays a pivotal role in ensuring the
quality, safety, and efficacy of medical devices,
given the potential serious implications of adverse
events associated with these devices. Raising
awareness about materiovigilance and Medical
Device-Associated Adverse Events (MDAEs)
among the general population is a fundamental step
in this direction. Materiovigilance programme of
India (MvPI) to monitor the safety of medical
devices in the country has been approved for the
commencement by the Ministry of health & family
welfare, Govt. of India. The MvPI was formally
launched on 06th July 2015 at IPC, Ghaziabad by
DCGI. Aim and Objective: To determine the
knowledge of materiovigilance among the people
and spreading awareness of materiovigilance
among mainly non-medical community. Materials
and Methods: This was a cross-sectional
questionnaire-based survey done among medical
students and non-medical people. A selfadministered, pre-tested, structured, pre-validated
questionnaire was distributed to 400 people. The
questionnaire consists of 6 questions pertaining to
knowledge of materiovigilance. A survey software
“google form” was used to analyze the data.
Results: A total of 312 responses were received. 88
people were not willing to participate in the study
so they were excluded. Only 3 % (13) of the
community had complete knowledge about various
aspects of materiovigilance and MvPI. About 9%
(35) of people had adequate knowledge. 21% (82)
of community had moderate knowledge. About
21.34% (84) people only knew about medical
devices. 24% (98) were even did not know what
are medical devices.
Understanding rasa and Its Impact on Digestion and Metabolism
Authors: Sanjay Ingale Vd. Rupali , Ashok Pati Vd. Sandip , Lungare Vd. Sanjay
Published: December 2024

In this article we examine the influence of Rasa
(taste) on digestion within the framework of
Ayurveda. In this system, Rasa includes six
primary tastes: Madhura, Amla, Lavana, Katu,
Tikta, Kashaya each possessing unique
characteristics that impact the digestive process.
These tastes play a crucial role in modulating Agni
(digestive fire), which is vital for breaking down
food, absorbing nutrients, and supporting metabolic
functions. Madhura flavours provide nourishment
and energy, sour tastes enhance appetite and
facilitate digestion, while Amlafoods promote
hydration and support digestive enzyme
activityKatuandTiktatastes are known to assist in
detoxification and stimulate metabolism, whereas
Kashaya flavourshelp regulate appetite and
maintain digestive health. By understanding the
effects of Rasa on digestion, individuals can make
informed dietary choices that enhance digestive
function and overall well-being, considering
personal constitution and seasonal variations. This
analysis highlights the importance of a balanced
approach to taste in fostering effective digestion
and metabolic balance.
A Review of Application of Immunomodulator Drugs in Nasya Treatment
Authors: Kothekar Dr. Vedanti , Charde Dr. Alka
Published: December 2024

Nasya karma is one of the important
therapeutic aspects for urdhwajatrugata diseases. It
is the process of administering the medicated oils,
other dravyas, etc through the nasal route. It is the
unique panchakarma process of shodhanachikitsa
in which medicine reaches to the brain and ejects
the vitiated dosha responsible for producing the
disease. Imunomodulator drugs are the substances
that can change the immune system’s response to
help the body fight disease. In ayurveda shashtra
immunomodulatory drugs are compared to the
rasayana Dravya. Taking rasayan is helpful to
increase the immunity of the person to keep him
away from diseases and also reverse the disease
process and re-occurrence. In this paper the
application of immunomodulator drugs for
nasyakriya is studied.
A Review Article on Method Development and Validation of Verapamil by RP-HPLC Method
Authors: Parmar Raghuveersinh , Patil Dr. Priyanka , Shah Dr.Chainesh , Upadhyay Dr.Umesh
Published: December 2024

High performance liquid chromatography, one of
the most powerful analytical techniques utilized in
the separation, identification, and quantification of
complex mixtures. Reverse-phase or RP-HPLC is
commonly practiced in high performance liquid
chromatography because this technique has the
advantages of versatility and appropriateness for
more hydrophobic compounds. Fundamentals and
Practices of Reversed-Phase HPLC: Part II -- RPHPLC column configurations. It consists of the
concept of separation, types of stationary and
mobile phases with the variables concerned with
the separation. This review discusses the necessity
for development and validation of such methods
along with its pharmaceutical and food industry
purposes as well as environmental analysis benefits
by RP-HPLC. Among the latest developments in
RP-HPLC, new stationary and mobile phases for
high-performance liquid chromatography based on
hydrophobic interactions have also emerged.
Changes like RP-HPL down-sizing techniques and
coupled For have also gained prominence. In
reversed-phase high-performance liquid
chromatography, short for RP-HPLC, the
separation of molecules takes place based on their
hydrophobicity. Separation is based on the
hydrophobic binding of the solute molecule from
the mobile phase to immobilized hydrophobic
ligands attached to the stationary phase, or sorbent.
Study on Degradation of Azodyes through Bioremediation
Authors: Akshaya A Akshaya A , Prabhahar B Prabhahar B , Felix CK Jones , Ramesh M Ramesh M , Kumaravel S Kumaravel S
Published: December 2024

Azo colours are widely used in textile, leather, and
other projects, but because of their toxic,
mutagenic, and carcinogenic qualities, they pose a
serious environmental risk. Conventional methods
of treating effluents
containingcolourareoftenwasteful,expensive, or
irrational. Utilising microorganisms such as
parasites, green growth, and microscopic
creatures,bioremediationisaneco-friendlyand astute
alternative that transforms these artificially
coloured substances into non-toxic outcomes.
Pseudomonas species have demonstrated
remarkable potential among microorganisms due to
their adaptability to
variousenvironmentsandmetabolicflexibility. The
main focus of this work is the enhanced conditionsbased degradation of azo colours using
Pseudomonas microorganisms. The azo reductase
enzyme's enzymatic breaking of the azo bond (-
N=N-) is one of the microbial debasement
processes that reduces the colour atoms to less
hazardous, less lustrous amines. Depending on
external factors, these intermediaries can be
biotransformed into simpler mixes via either
anaerobic or oxygen- consuming processes.
Important factors influencing the efficiency of
debasement, such
aspH,temperature,oxygenconcentrations,and the
availability of supplies of carbon and nitrogen,
were simplified. The results
demonstratethatPseudomonasmayeffectively
contaminate azo colours at neutral pH levels (about
7), moderate temperature ranges (25°C
to37°C),andinthepresenceofelectrondonors. To
ensure complete colour disintegration, replacing
anaerobic-high-impact conditions was very
persuasive. This investigation
demonstratesthepotentialofbioremediationas acosteffectivesolutionfortreatingwastewater
contaminated with azo colours, providing a
workable approach to natural administration
andpollutionmanagement.Additionalresearch on
growing and improving microbial consortiums can
improve the effectiveness of contemporary
wastewater treatment.
Homo viator. Los sentidos del caminar
Authors:   Universidad del Valle, Flórez González Fernando , Mora Olarte Eugenia ,   Universidad del Valle, Perafán González Diana Yasmín ,   Universidad Santiago de Cali
Published: December 2024

El capitulo está dividido en: cuatro partes; 1. Una hazaña biológica: la ubicuidad del ser humano, 2.Los pies sobre la tierra, 3.De las ascidias y otros caminantes y finalmente 4.el sedentarismo voluntario: homo viator asistido.
GENERALIDADES DE LA MARCHA NORMAL
Authors:   Universidad Santiago de Cali, Perafán González Diana Yasmín
Published: December 2024

En este capítulo el lector podrá hacer un recorrido por la historia de los sistemas de evaluación de la marcha y cómo los grandes pensa-dores se mostraron interesados por la comprensión del sistema de locomoción humano, centros de masa corporal, efecto gravitatorio sobre el cuerpo humano, también encontrará la relación que han he-cho escritores de la talla de Balzac entre la forma de deambular sus personajes con características socioeconómicas y emocionales de los mismos.
AYUDAS TÉCNICAS PARA LA MARCHA. CONCEPTOS Y PRESCRIPCIÓN
Authors:   Universidad Santiago de Cali, Calero Saa Pedro Antonio
Published: December 2024

En este capítulo, se realizará una descripción de los conceptos globales de las ayudas técnicas para la marcha, como también la descripción de cada ayuda, así como su prescripción. Se inicia con una conceptualización desde los entes gremiales tanto nacionales como internacionales como son la International Organization for Standardization (ISO), la American Physical Therapy Association (APTA), la Wolrd Confederation For Physical Therapay (WCPT) y la Organización Mundial de la Salud (OMS).
IMPETRAÇÃO DE MANDADO DE SEGURANÇA EM FACE DE DECISÕES INTERLOCUTÓRIAS APÓS O JULGAMENTO PELO SUPERIOR TRIBUNAL DE JUSTIÇA DO TEMA 988 QUE FIXOU A TAXATIVIDADE MITIGADA DO AGRAVO DE INSTRUMENTO
Authors: Onety Thaís Oliveira
Published: December 2024

O presente artigo trata acerca da impetração de mandado de segurança em face de decisões interlocutórias após a tese fixada, em sede de recursos repetitivos, que entendeu pela taxatividade mitigada do rol do art. 1.015 do Código de Processo Civil (CPC). Aborda, inicialmente, as disposições do diploma processual civil acerca do referido recurso, após apresenta os embates doutrinários sobre a natureza do rol do art. 1.015 e a posição do Superior Tribunal de Justiça (STJ). Depois, discute sobre a utilização do mandado de segurança para combater atos judiciais conforme a legislação e o posicionamento dos Tribunais Superiores. Ao final, aborda, especificamente, sobre o manejo daquela ação constitucional em face de decisões interlocutórias de acordo com recente jurisprudência do STJ.
Agensi Kelembagaan Modal Sosial Dalam Tata Kelola Wisata Bahari di Pantai Martajasah, Kabupaten Bangkalan, Jawa Timur
Authors: Purwanto Edy , Mulyaningsih Hetti
Published: December 2024

This article aim to explore the social capital strategy in marine tourism governance which crucially contributes as strength and resilience in maintaining the sustainability principles of tourist destinations that are experiencing the challenges of social change. This study uses the theory of practice social capital approach from Pierre Bourdieu with qualitative research methods and an analytical-case approach using observation techniques, in-depth interviews and focus group discussions which are concentrated on the aspect of tourism governance. The findings of this study succeeded in revealing that the cross-sectoral institutional agency network model in Martajasah beach produced a “capital reproductive strategy” and “capital conversion strategy”. First, the existence of the capital reproduction strategy has succeeded in urging the authorities of the "state apparatus" in spreading network to collaborate between the tourism office, the marine service and private companies. Second, the conversion strategy seeks to be intertwined with community leaders, NGOs and educational institutions as a trinity of "institutionalized cultural capital" which has the "rules of the game" in exchanging social capital into cultural capital to support the quality of tourism attraction governance through donations and training. Capital reproduction strategy and capital conversion strategy are the power of social capital where resources can be accumulated in turning vulnerability into resilience so that Martajasah beach can be maintaining the "status quo" as a leading tourist destination in the dynamics of social change.
Impact of Coffee Tourist Attractions on Visit Intentions of Generation Y and Z
Authors: Mukti Bentar Sagara , Priyambodo Tri Kuntoro , Irwan Siti Nurul Rofiqo
Published: December 2024

This study investigates the influence of coffee tourist attractions (CTA) on the visit intentions of Generation Y and Generation Z. Utilizing a quantitative research framework, surveys were conducted to assess how product quality, service quality, and atmospheric of coffee shops as tourist destinations. The sample consisted of 314 respondents from Yogyakarta, including both generations. The results demonstrate that both Generation Y and Z are significantly influenced by the quality of products, services, and coffee shop atmosphere with Generation Y placing greater emphasis on personal recommendations and traditional marketing, while Generation Z relies more on digital interactions and social media. These findings highlight the importance of tailored marketing strategies to effectively attract each generational cohort. The study concludes that enhancing product quality, service, and atmosphere of coffee shops can positively impact their attractiveness as tourist destinations for both Generation Y and Z.
Utilization of Digital Teaching Methods for Interactivity and Effective Delivery at Basic School Levels in Kaduna, Nigeria
Authors: Bara’u Dr. Rabi
Published: December 2024

Technology has found its way slowly but surely into the classroom. This calls for the need to write on the title “Utilization of Digital Methods of Teaching for Interactivity and Effective Teacher Delivery at Basic Levels in Kaduna State.” Teachers are now exposed to using technological facilities in the instructional process to increase their abilities to use ICT gadgets for individualized instruction and assessment, arousing learners’ interest, retaining attention, and facilitating assimilation, understanding, recall, interaction, and collaboration. COVID-19 has opened a new normal in the classroom, where the sudden closure of schools calls for virtual or digital instruction. This technology can be applied to inject content, ideas, or encourage interactivity with or without a teacher. Trainees and teacher educators need to be exposed to these digital methods of teaching to remain updated, relevant, and technology-compliant. The paper discusses the nature and characteristics of technology-based methods, identifies six digital instructional methods for effective facilitation in the 21st century, and presents the processes, resources, problems, and recommendations for effective utilization. These elements are discussed in the paper for innovation and sustainability in Teacher Education.
Effects of Foliar Application of Various Antioxidants on Growth, Physiological, Biochemical and Yield Attributes of Maize Grown Under Saline Conditions
Authors: Ismail Asif , Amin Romaisa , Nasrullah Uzma , Saleem Maryam , Kousar Mehnaz , Ameen Muhammad , Riaz Areeba , Elahi Ayesha , Farooq Muhammad
Published: December 2024

Maize crop is cultivated for the purpose to obtain high production of grains. Term maize is derived from Latin language, meaning life benefactor. Its grains possess high nutritional values. Because of high importance of maize grains, a study was performed according to CRD by three replications to examine the mitigating effects of antioxidants such as citric acid, ascorbic acid and salicylic acid to salt toxicity. Foliar application of these three antioxidants were done at 200 ppm concentration and one treatment as mixture of 100 ppm of all three antioxidants. Data was noted for different growth, physiological and yield attributes. Analysis of data revealed that 100 ppm concentration mixture of all three antioxidants provided highest results for all attributes. The 100 ppm antioxidant mixture foliar application caused 8% increase in plant height and 29% increase in ear length as compared to controlled plants sprayed with water. It also caused significant increase in concentration of all photosynthetic pigments such as Chl a, Chl b and carotenoids. Foliar application with 100 ppm of antioxidant mixture also caused 21% increase in catalase activity and 27% increase in peroxidase activity. This treatments also helped plants to accumulate more potassium and provided lowest (0.44) Na+/K+ ratio. Hundred grain weight was observed highest (44.7) in plants sprayed with 100 ppm of antioxidant mixture. Harvest index of those plants were also highest (45.65). So, from these results it can be assumed that 100 ppm antioxidant mixture foliar application provided highest results followed by 200 ppm concentration of ascorbic acid.
Suicide and Its Prevention Strategies in India: A Comprehensive Review
Authors: Ainapur Mrs Savita , Mareguddi Ms Jyoti
Published: December 2024

Suicide is a multifaceted issue that presents a significant challenge to public health worldwide, impacting individuals, families, and communities. This article offers a thorough examination of the occurrence, factors contributing to, and methods of preventing suicide, focusing specifically on the Indian context. Despite continuous endeavors, suicide rates in India persist at concerning levels, underscoring the necessity for cohesive interventions and cooperative prevention approaches. Through an analysis of current research and programs in this area, this article seeks to enhance comprehension of suicide prevention endeavors in India and guide forthcoming tactics to address this critical public health concern.
Prevalência e impactos das internações por neoplasias de pele no Brasil: Uma análise epidemiológica (2014-2024)
Authors: Pacheco Leão Stefanny , Da Silva Avelar Luanda , De Oliveira Silva Bibione Tercia , Lavoratti Anna Claudia , Da Silva e Silva Thawanny , Fonseca Pinheiro Giovanna , Machado de Souza Pablo Matheus , Teixeira de Freitas Iasmin Barretto , Oliveira da silva Nathalia , Souza Melo Victor Miguel , Almeida Machado Beatriz De , Oliveira Bastos de Almeida Ana Paula , Arrais Sousa Samara , Ferreira da Trindade Ronimara , Miranda Filho Kleber Moreira
Published: December 2024

Introdução: O câncer é uma das principais causas de morte no Brasil e um enorme problema de saúde pública mundial, ele surge do crescimento descontrolado das células da pele, sendo o melanoma mais perigoso pela sua capacidade de se espalhar. Além disso, fatores como exposição solar, histórico familiar, imunossupressão, exposição a substâncias cancerígenas e predisposição genética podem contribuir para o desenvolvimento do câncer de pele maligno. Objetivo: O artigo objetiva trazer uma análise epidemiológica, da prevalência e impactos da neoplasia de pele no Brasil e nas suas macrorregiões, no período de janeiro de 2014 a junho de 2024. Metodologia: Trata-se  de  um  estudo  epidemiológico,  retrospectivo  com  abordagem quantitativa e temporal, com dados referentes à prevalência e impactos das internações  no  período  de  2014  a  2024,  nas cinco regiões brasileiras. Resultados: Os resultados revelaram desigualdades regionais significativas nas internações por neoplasias malignas de pele no Brasil. A região Sudeste concentrou 40,2% das internações (31.565 casos), seguida pelas regiões Sul (33,8%) e Nordeste (18,78%). Em termos de permanência hospitalar, a região Norte apresentou a maior média (5,3 dias). O perfil mais acometido incluiu homens (51,9% dos casos), pessoas de pele branca (61,9%), e indivíduos idosos, com média de idade de 71 anos nos casos confirmados. A mortalidade foi predominante no Sudeste (45% dos óbitos) e Sul (31,5%). Conclusão: Os resultados obtidos demonstram a relevância epidemiológica das neoplasias malignas de pele no Brasil, evidenciando desigualdades regionais significativas tanto em termos de prevalência quanto de acesso aos serviços de saúde.
TCHAU, TCHAU SUJEIRA: PROMOÇÃO DE SAÚDE E HIGIENIZAÇÃO PARA CRIANÇAS DO LIXÃO DO MUNICÍPIO DE CODÓ
Authors: Luz Alan Luiz Portela Moura , De Sousa Coelho Carlos Yann , Dos Reis Daniel Almeida , Da Silva Danilo Vieira , Sampaio Francisco Augusto De Freitas , Dias Hélio Silva , Silva Hengrid Graciely Nascimento , Teixeira Kayron Ruan Araújo
Published: December 2024

Introdução: A higiene corporal é um conjunto de comportamentos que corroboram para garantir uma vida mais saudável. Para crianças, a aprendizagem desses comportamentos ajuda a consolidar um desenvolvimento saudável, proporcionando um bem-estar físico, mental e protegendo contra possíveis agentes externos.  Objetivos: Relatar a experiência do projeto de extensão universitária “TCHAU, TCHAU SUJEIRA” projeto com foco na prevenção e promoção de saúde através do ensino sobre boa higienização. Metodologia: Trata-se de um estudo descritivo do tipo relato de experiência, no qual foi colocado em prática o projeto de extensão “Tchau, Tchau Sujeira”, que foi planejado durante o segundo semestre de 2024 e com ação realizado no dia 17 de outubro do mesmo ano. Resultados: Foi possível perceber a empolgação e participação das crianças presentes na ação durante as atividades realizadas, que mostraram ter interesse na abordagem do assunto e relataram como eles praticavam no dia a dia tais hábitos de higiene em cada tópico conversado, bem como a adesão dos pais no local aos conhecimentos levados pelos alunos, que também se mostraram gratos pela experiência e aproximação da faculdade com a comunidade diante de um tema tão relevante e necessário. Conclusão: Diante disso, o projeto de extensão revelou-se uma valiosa ferramenta social de saúde, assistindo uma comunidade carente e promovendo qualidade de vida àqueles que têm acesso limitado a informações sobre práticas corretas de higiene.
Artroplastia Total de Rodilla: Eficacia del Bloqueo del Nervio Femoral en el Manejo del Dolor Postoperatorio.
Authors: Méndez Alarcón Manuel Fernando , Saona Alejandro Emily Denisse , Naranjo Garcia Maholy Elizabeth , Rodriguez de la Torre María Auxiliadora , Moriera Morán Marlon Vicente
Published: December 2024

Introducción: La artroplastia total de rodilla (ATR) es un procedimiento quirúrgico común para sustituir la articulación de la rodilla por una prótesis y aliviar el dolor en enfermedades articulares graves. La gestión eficaz del dolor postoperatorio es crítica para la recuperación. Tradicionalmente se han usado opioides, pero debido a efectos secundarios se buscan alternativas como los bloqueos nerviosos periféricos. Objetivo: Este estudio analiza la eficacia del bloqueo del nervio femoral (BNF) en el manejo del dolor postoperatorio tras ATR. Metodología: Se realizó una revisión bibliográfica en bases de datos como PubMed, Scopus y Web of Science enfocada en estudios desde 2014. Los términos de búsqueda incluyeron "bloqueo del nervio femoral", "manejo del dolor postoperatorio", y "artroplastia total de rodilla" abarcando revisiones sistemáticas y ensayos clínicos. Resultados: El BNF resultó efectivo para reducir el dolor postoperatorio y el uso de opioides. Si bien el BNF continuo mostró aliviar moderadamente el dolor, otros estudios señalaron debilidad muscular. Comparaciones mostraron que el bloqueo del canal aductor (BCA) brindó una analgesia similar con menor impacto en el músculo. Discusión: Aunque el BNF reduce eficientemente el dolor y el consumo de opioides, presenta riesgos como la debilidad del cuádriceps, afectando la movilidad. Técnicas emergentes como el BCA y el iPACK ofrecen beneficios analgésicos similares con potencialmente menos complicaciones. Conclusión: El BNF es valioso en el manejo del dolor postoperatorio tras ATR, aunque debe considerarse cuidadosamente la debilidad muscular. Las estrategias multimodales que incorporan varios bloqueos nerviosos pueden mejorar la recuperación y reducir complicaciones, subrayando la necesidad de investigar para mejorar estos enfoques.
Evaluation of the efficiency of finishing turning of alpha titanium alloys by the lowest energy dissipation
Authors:   Snegireva K.K. Fomin E.V. Hudyakov M.P. Rusanovskiy S.A.
Published: December 2024

An efficiency coefficient based on energy dissipation is proposed to determine the optimal mode of finishing turning of alpha-titanium alloys, which ensure the best quality of the treated surface.

Keywords
finishing turning, alpha-titanium alloy, efficiency coefficient, energy dissipation, surface roughness, steady cutting, localized shear, loss of macroscopic stability
k.snegireva@narfu.ru, e.fomin@narfu.ru, m.khudyakov@narfu.ru, s.rusanovskiy@narfu.ru
Ensuring the accuracy of the location of the shaft axes of gearboxes using the compensation method
Authors:   Leonov O.A. Shkaruba N.Zh. Grinchenko L.A.
Published: December 2024

To ensure the accuracy of the shaft axes location of the H.094.44.000-323 and H.090.20.000-121 gearboxes of the КПК-2-01 potato harvester, a dimensional chain diagram is constructed. The analysis of tolerances and deviations of the dimensional chain links showed that the accuracy of the master link can be ensured by the compensation method, using sets of four fillers of the same thickness or three fillers of different thickness. It is recommended to use a compensator of three fillers. Their sizes are determined taking into account the deviations.

Keywords
gearbox, shaft, assembly quality, dimensional chain, incomplete interchangeability, compensation method
oaleonov@rgau-msha.ru, shkaruba@rgau-msha.ru, agrinchenko@rgau-msha.ru
ЛЕЧЕБНО-ПРОФИЛАКТИЧЕСКИЕ МЕРОПРИЯТИЯ
ПРИ КАЛИЦИВИРУСНОЙ ИНФЕКЦИИ КОШЕК
Authors: Абдулхажиева А.Ш. , Гудаева М.М.-Э.
Published: December 2024

Для кошек, заболевших калицивирусной инфекцией, не существует специфического лечения. Антибиотики назначаются в целях предотвращения вторичной инфекции. Поддерживающая терапия и обильное питье помогают организму кошек в борьбе с калицивирозом.
МОНИТОРИНГ ЗЕМЕЛЬ СЕЛЬСКОХОЗЯЙСТВЕННОГО
ЗНАЧЕНИЯ ЧЕЧЕНСКОЙ РЕСПУБЛИКИ
Authors: Адаев Н.Л. , Амаева А.Г.
Published: December 2024

Мониторинг состояния земель сельскохозяйственного назначения в Чеченской Республике с использованием географических информационных систем (ГИС) является важным инструментом для оценки и управления сельскохозяйственными ресурсами региона. В данной работе рассматриваются современные методы и технологии ГИС, применяемые для анализа состояния земель, включая их использование для выявления изменений в землепользовании, оценки качества почв и мониторинга воздействия климатических изменений. Основное внимание уделяется сбору и обработке данных с помощью дистанционного зондирования, а также применению аналитических инструментов для создания карт и моделей, которые помогают в принятии обоснованных решений в области сельского хозяйства. Результаты мониторинга позволяют оптимизировать использование земельных ресурсов, повысить их продуктивность и устойчивость к внешним факторам. В итоге использование ГИС-технологий становится неотъемлемой частью эффективного управления земельными ресурсами Чеченской Республики, способствуя устойчивому развитию сельского хозяйства в регионе.
НАУЧНОЕ ОБЪЯСНЕНИЕ ОСНОВНЫХ АРОМАТОВ ВИНА
Authors: Ляхова А.А. , Пацюченко М.М. , Хализов М.В.
Published: December 2024

В данной статье приведена классификация ароматов вин по трём группам: ароматы, свойственные самому винограду; ароматы, раскрывающиеся в процессе ферментации; ароматы, которые появляются при выдержке вина. Кроме того, в ней рассмотрены различные классы химических соединений винограда и вина. А именно сложные эфиры, терпены, альдегиды, дикетоны и кетоны, спирты, кислоты, меркаптаны и пиразины, непосредственно влияющие на аромат напитка. Изучены их химические и биохимические превращения, которые влияют на формирование аромата и букета вина. Также рассмотрены сложные механизмы восприятия запахов органами чувств человека и приведены советы для развития индивидуальной органолептики с помощью ассоциаций. Статья не только даёт общее понимание о винной культуре, но и более углубленно затрагивает химию самого напитка.
Entre lives e dossiês:
Authors: Silveira Martins Raquel
Published: December 2024

As revistas acadêmicas de História são o mote desse artigo que busca compreender de que forma a pandemia da COVID-19 entre 2020 e 2021 impulsionou a presença desses periódicos nas redes sociais digitais. Para tanto, foram analisadas as redes das revistas classificadas como A1 pelo sistema Qualis Capes na área de História. Mais que apontar dados quantitativos, o artigo busca nuanças de uso das redes pelas revistas considerando assim postagens, comentários e links como fontes históricas. O que se demonstra aqui é que as revistas vêm usando o potencial das redes para divulgação de suas publicações e para construir novas formas de discussão e diálogo com a comunidade de leitores-autores que congrega. O contexto pandêmico potencializa essa produção através da utilização de ferramentas como os recursos de live, da possibilidade de mais tempo e engajamento nas redes, bem como pela oportunidade de se aproximar de um público interessado, mas distante geograficamente. Ressalta-se ainda que a produção das revistas voltada às redes sociais digitais desenvolve formas de comunicação que amplia o público leitor e interessado nas pesquisas acadêmicas de História.
História Pública e Maretórios:
Authors: Pereira da Costa Junior Ademas
Published: December 2024

Este artigo, tem como objetivo apresentar a relevância dos maretórios para os novos estudos de história pública no Brasil. Considera as tendências e desdobramentos da mobilização histórica das comunidades de pesca artesanal, propondo ao leitor uma investigação e uma interpretação historiográfica com base na metodologia de pesquisa participativa realizada no LABHOI-UFF, segundo princípios estabelecidos pelas noções de corpo-história, memória e intertextualidade. O artigo coloca em evidência o processo de construção de uma narrativa historiográfica de síntese que se filia a questões socialmente vivas, e implicada a uma visada sobre que lugar o historiador público deve ocupar na história do tempo presente.
Apresentação – Dossiê: UEMG 35 anos: desafios e possibilidades
Authors: Da Silva Tiago Aparecido
Published: December 2024

Apresentação – Dossiê: UEMG 35 anos: desafios e possibilidades
Desventuras da autonomia universitária:
Authors: Da Silva Tiago Aparecido
Published: December 2024

A presente reflexão levanta o problema da autonomia universitária no Brasil, com foco no caso da Universidade do Estado de Minas Gerais (UEMG). Argumentamos que, com raríssimas exceções, nossas instituições públicas de educação superior vivenciam uma condição heterônoma, resultando em graves limitações que dificultam a missão de garantir ensino e extensão de qualidade e pesquisa acadêmica de ponta.
INFLUENCE OF FEED ADDITIVES COMPLEX ON THE PHYSICOCHEMICAL COMPOSITION OF MILK IN SUBCLINICAL KETOSIS IN COWS
Authors: Zabolotnyh Mihail , Il' Elena , Il' Dmitriy
Published: December 2024

The objective of the study is to identify the effectiveness of using a complex of feed additives on milk quality and milk productivity in highly productive cows with subclinical ketosis. The studies were conducted in the production conditions of a dairy complex in the north of Kazakhstan in 2020–2023. For the experiment, 40 highly productive fawn-motley third-calving Simmental cows were selected. All animals were kept in identical feeding and housing conditions. The selected animals were formed into two groups of 20 animals: Group 1 (control) – clinically healthy animals and Group 2 (experimental) – animals with subclinical ketosis. Animals with subclinical ketosis received "basic diet + liquid polysaccharides + vitamin-mineral premix + Menonic-50 + tricalcium phosphate". Studies were conducted on changes in milk productivity and the qualitative composition of milk after the introduction of liquid polysaccharides Polis, Menonik-50, tricalcium phosphate and premix for dairy cattle in subclinical ketosis in highly productive cows into the diet. When testing the applied scheme of introducing feed additives, the following main criteria were identified: increase in average daily milk yield, improvement of physicochemical parameters of milk, as well as improvement of energy balance and metabolic processes, replenishment of vitamins and minerals in the diet of highly productive animals. After using feed additives, the dynamics of change in average daily milk yield by 14.76 % is observed. There is a reliable increase in the protein level by 25.8 %, whey proteins by 19 % at p ≤ 0.001. The amount of dry skim milk residue increased by 11.5 %. A decrease in acidity in milk by 15.4 % is noted, the indicator was 17.31 °T and was within the normal range. The feed additives proposed for the prevention of subclinical ketosis help to improve carbohydrate and mineral metabolism in the body, increase the sugar-protein ratio in diets, increase productivity and change the qualitative composition of raw milk.
STUDY OF THE PHYSICOCHEMICAL METHODS OF PECTIN EXTRACT PROCESSING INFLUENCE ON THE PECTIN PRECIPITATION PROCESS EFFICIENCY
Authors: Semenihin Semen , Fabrickaya Alla , Gorodeckiy Vladimir , Daisheva Nailya , Kotlyarevskaya Natal'ya , Usmanov Mirsabir
Published: December 2024

The aim of the study is to identify the effect of physicochemical methods of pectin extract processing on the efficiency of the pectin precipitation process. Objectives: to determine an effective neutralizing agent for regulating the pH value of pectin extract and the pH value of pectin extract, providing a high degree of pectin precipitation using 96 % ethyl alcohol. The objects of the study are pectin extract obtained from fermented beet pulp using an aqueous solution of citric acid and a composition of enzymes consisting of cellulase, xylanase and protease, as well as pectin obtained from pectin extract by precipitation with 96 % ethyl alcohol. Increasing the pH value of pectin extract from 4.1 to 6.0, both with the use of ammonium hydroxide solution as a neutralizing agent and with the use of sodium hydroxide solution, makes it possible to increase the degree of pectin precipitation from the extract using 96 % ethyl alcohol. The degree of pectin precipitation from pectin extract with a pH of 6.0 in the case of using sodium hydroxide solution as a neutralizing agent is significantly higher (by 11.0 %) compared to this indicator in the case of using ammonium hydroxide solution as a neutralizing agent and is 85.7 %. The purity of pectin obtained from pectin extract (pH 6.0) using sodium hydroxide solution as a neutralizing agent is 11.6% higher than with ammonium hydroxide solution and is 86.7 %. Further promising studies are studies of the efficiency of manifestation of bioactive and technological properties by the obtained pectin for the purpose of its application in food technology.
IMPROVING THE SHADOW SECTOR STATE CONTROL SYSTEM IN THE ECONOMIC SECURITY INTERESTS
Authors: Stanovaya Anna
Published: December 2024

The paper presents an analysis of the state system of control (supervision) over the shadow economy and develops recommendations for its containment in a state that allows using its advantages in the conditions of economic turbulence and sanctions. The complexity of the tasks to be solved is due to the a priori negative impact of the shadow economy on the national economic system and national economic security. At the same time, in the current foreign economic and foreign policy situation, it is necessary to turn to non-standard tools that allow, including through import substitution, to ensure the growth of the Russian economy and counteract the pressure of sanctions. The author provides a system of evidence for strengthening state control at the current stage, since in the conditions of economic uncertainty and the speed with which changes occur, the use of only economic regulators is far from always justified. At the same time, the work shows that excessive passion for state control in the long term can have a negative impact on the competitiveness of the Russian economy and its attractiveness for foreign partners, even from friendly countries. In this situation, it is necessary to find a certain balance that takes into account many different economic and non-economic factors and requirements in the field of ensuring economic security. The proposed recommendations related to the practical application of the state control system and its modernization take into account the specified factors and contribute to the most effective solution of problems in the field of economic security.