bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and luminescent properties of mesoporous (SBA-15)-Eu2O3 nano materials
Authors: Zhang Shuhua , Geng Zhigang , Zhang Weina , Yang Xiuyun , Gao Ying , Li Leijiao , Ma Yuqin , Li Yunhui
Published: September 2018

The CH3-(SBA-15) and (SBA-15)-Eu2O3 host-gust nanocomposite materials were synthesized by post-synthesis method, ultrasonic synthesis method (UM) and ultrasonic assisted synthesis methods (UAM). The X-ray diffraction (XRD), infrared spectroscopy (IR), scanning electron microscopy (SEM), transmission electron microscope (TEM) analysis and nitrogen adsorption-desorption method were used to observe the structure, the surface morphology and the chemical composites of the prepared products. The luminescent properties, and the luminescent intensity of the samples were studied by excitation and emission spectra. The results showed that, for the (SBA-15)-Eu2O3 composite materials, the hexagonal pore structure of the SBA-15 molecular sieve was maintained. The luminescent intensity of the UM sample was about 6 times higher than that of the mechanical mixture of SBA-15 and nano-Eu2O3 (5 wt %). The excitation spectrum intensity was 2 times higher than that of the mechanical mixture.
Synthesis, structure and photocatalytic properties of two hybrid compounds prepared by N-methyl-4,4′-bipyridinium chloride
Authors: Wang Fu-Rong , Wang Chao-Hai , Wu Ben-Lai , Yan Zhen-Ning , Niu Yun-Yin , Hou Hong-Wei
Published: September 2018

Cationic ligand N-methyl-4,4’-bipyridine (MQ) (Scheme 1) reacted respectively with metal halides and pseudohalides to form two organic-inorganic hybrid materials: [MQ][CuI2] (1), [Cu(MQ)(SCN)2] (2), which were characterized by single-crystal X-ray diffraction analyses, infrared spectra (IR), elemental analyses, powder X-ray diffraction (PXRD), and thermogravimetric (TG) analyses. The anion structure of compound 1 is binuclear and 2 is two-dimensional. Compounds 1- 2 show the better characteristic of degradating methylene blue (MB) in water under 500 W Xe vapor lamp irradiation.
Cannabidiol for Treatment of Childhood Epilepsy–A Cross-Sectional Survey
Authors: Klotz Kerstin A. , Schulze-Bonhage Andreas , San Antonio-Arce Victoria , Jacobs Julia
Published: September 2018

Background: The interest in cannabidiol (CBD) for treatment of epilepsy has been increasing over the last years. However, practitioner's attitudes concerning the use of CBD for epilepsy treatment appears to be divided and data about its clinical use in daily practice are not available.

Objective: To improve the knowledge about the current use of CBD amongst European practitioners treating children and adolescents for epilepsy.

Methods: Cross-sectional survey using an open-access online questionnaire for physicians treating children or adolescents for epilepsy within eight European countries from December 2017 to March 2018.

Results: One-hundred fifty-five physicians participated in the survey. CBD is increasingly used by 45% (69/155) of participants, treating a mean (range) number of 3 (1–35) with CBD. Only 48% of the participants prescribing CBD are exclusively using purified CBD to treat children and adolescents with epilepsy, the remainder also applies preparations containing delta9-tetrahydrocannabinol (THC). Reported daily CBD doses range from < 10 to 50 mg/kg body weight. Management of CBD therapy in regard of monitoring side effects and adjusting concomitant therapy differs widely amongst participants. Their primary objective for commencing CBD is improving patient's quality of life. Participants frequently receive inquiries about CBD treatment but only 40% may actively suggest CBD as a treatment option. Of the 85 participants currently not using CBD for epilepsy treatment, 70% would consider using CBD if available in their country of practice or given the opportunity to become familiar with this treatment option.

Conclusions: CBD is increasingly used by participating physicians but individual experience remains limited. There are very diverse opinions about the use of CBD to treat epilepsy in children and adolescents and widely differing views on how to manage the CBD treatment.
RETRACTED: CuO and CeO2 Nanostructures Green Synthesized Using Olive Leaf Extract Inhibits the Growth of Highly Virulent Multidrug Resistant Bacteria
Authors: Maqbool Qaisar , Nazar Mudassar , Maqbool Ayesha , Pervez Muhammad T. , Jabeen Nyla , Hussain Talib , Franklin Gregory
Published: September 2018

One of the major challenges of nano-biotechnology is to engineer potent antimicrobial nanostructures (NS) with high biocompatibility. Keeping this in view, we have performed aqueous olive leaf extract mediated one pot facile synthesis of CuO-NS and CeO2-NS. Prepared NS were homogenous, less than 26 nm in size, and small crystallite units as revealed by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses. Fourier transform infrared spectroscopy (FTIR) of CuO-NS and CeO2-NS showed typical Cu-O prints around 592–660 cm-1 and Ce-O bond vibrations at 453 cm-1. The successful capping of CuO-NS and CeO2-NS by compounds present in the plant extract was further validated by high performance liquid chromatography (HPLC) and thermal gravimetric analysis (TGA). Active phyto-chemicals from the leaf extract simultaneously acted as strong reducing as well as capping agent in the NS synthesis. NS engineered in the present study showed antibacterial potential at extremely low concentration against highly virulent multidrug-resistant (MDR) gram-negative strains (Escherichia coli, Enterobacter cloacae, Acinetobacter baumannii and Pseudomonas aeruginosa), alarmed by World Health Organization (WHO). Furthermore, CuO-NS and CeO2-NS did not show any cytotoxicity on HEK-293 cell lines and Brine shrimp larvae indicating that the NS green synthesized in the present study are biocompatible.
Correction: Si, X., et al. Combined Process of Ozone Oxidation and Ultrafiltration as an Effective Treatment Technology for the Removal of Endocrine-Disrupting Chemicals. Appl. Sci. 2018, 8, 1240
Authors: Si Xiurong , Hu Zunfang , Huang Shiyuan
Published: September 2018

We, the authors, wish to make the following correction to our published paper [...]
Analysis and Estimation of Geographical and Topographic Influencing Factors for Precipitation Distribution over Complex Terrains: A Case of the Northeast Slope of the Qinghai–Tibet Plateau
Authors: Liu Weicheng , Zhang Qiang , Fu Zhao , Chen Xiaoyan , Li Hong
Published: September 2018

Due to the complex terrain, sparse precipitation observation sites, and uneven distribution of precipitation in the northeastern slope of the Qinghai–Tibet Plateau, it is necessary to establish a precipitation estimation method with strong applicability. In this study, the precipitation observation data from meteorological stations in the northeast slope of the Qinghai–Tibet Plateau and 11 geographical and topographic factors related to precipitation distribution were used to analyze the main factors affecting precipitation distribution. Based on the above, a multivariate linear regression precipitation estimation model was established. The results revealed that precipitation is negatively related to latitude and elevation, but positively related to longitude and slope for stations with an elevation below 1700 m. Meanwhile, precipitation shows positive correlations with both latitude and longitude, and negative correlations with elevation for stations with elevations above 1700 m. The established multivariate regression precipitation estimating model performs better at estimating the mean annual precipitation in autumn, summer, and spring, and is less accurate in winter. In contrast, the multivariate regression mode combined with the residual error correction method can effectively improve the precipitation forecast ability. The model is applicable to the unique natural geographical features of the northeast slope of the Qinghai–Tibet Plateau. The research results are of great significance for analyzing the temporal and spatial distribution pattern of precipitation in complex terrain areas.
On Molecular Descriptors of Carbon Nanocones
Authors: Nazeer Waqas , Farooq Adeel , Younas Muhammad , Munir Mobeen , Kang Shin Min
Published: September 2018

Many degree-based topological indices can be obtained from the closed-off M-polynomial of a carbon nanocone. These topological indices are numerical parameters that are associated with a structure and, in combination, determine the properties of the carbon nanocone. In this paper, we compute the closed form of the M-polynomial of generalized carbon nanocone and recover many important degree-based topological indices. We use software Maple 2015 (Maplesoft, Waterloo, ON, Canada) to plot the surfaces and graphs associated with these nanocones, and relate the topological indices to the structure of these nanocones.
Nutrition Impact Symptoms Are Prognostic of Quality of Life and Mortality After Surgery for Oesophageal Cancer
Authors: Anandavadivelan Poorna , Martin Lena , Djärv Therese , Johar Asif , Lagergren Pernilla
Published: September 2018

We aimed to clarify the influence of nutritional problems after surgery for oesophageal cancer on functional health related quality of life (HRQOL) and survival. A prospective nationwide cohort of oesophageal cancer patients operated 2001–2005 in Sweden with 6 months postoperative follow up was used. Nutritional problems were categorized as low/moderate/severe/very severe based on weight loss and nutrition impact symptoms. An ANCOVA model calculated mean score differences (MD) with 95% confidence intervals (CI) of global quality of life (QOL), social and physical function scores, stratified by preoperative body mass index (BMI) <25 and ≥25. A Cox proportional hazards model produced hazard ratios (HR) with 95% CI for overall 5-year survival. Of 358 patients, 196 (55%) had preoperative BMI ≥25. Very severe and severe nutritional problems were associated with worse HRQOL in both BMI groups. E.g. MD’s for global QOL among ‘very severe’ group was −29 (95% CI −39–−19) and −20 (95% CI −29–−11) for <25 and ≥25 BMI, respectively, compared to the ‘low’ group. Overall 5-year survival among ‘very severe’ and BMI ≥ 25 was worse; HR 4.6 (95% CI 1.4–15.6). Intense nutritional problems negatively impact postoperative HRQOL and combined with preoperative BMI ≥ 25 are associated with poorer 5-year overall survival representing a group needing greater clinical attention.
Impact of Tumor Regression Grade as a Major Prognostic Factor in Locally Advanced Rectal Cancer after Neoadjuvant Chemoradiotherapy: A Proposal for a Modified Staging System
Authors: Song Changhoon , Chung Joo-Hyun , Kang Sung-Bum , Kim Duck-Woo , Oh Heung-Kwon , Lee Hye Seung , Kim Jin Won , Lee Keun-Wook , Kim Jee Hyun , Kim Jae-Sung
Published: September 2018

There is ongoing debate regarding the significance of complete or near-complete response after neoadjuvant chemoradiotherapy (CRT) for rectal cancer. This study assessed the prognostic value of the Dworak tumor regression grade (TRG) following neoadjuvant CRT and surgery primarily in patients with pathological stage (ypStage) II and III rectal cancer. The records of 331 patients who underwent neoadjuvant CRT followed by total mesorectal excision between 2004 and 2015 were retrospectively reviewed. Patients were categorized as having a good response (GR, TRG 3/4, n = 122) or a poor response (PR, TRG 1/2, n = 209). At a median follow-up of 65 months, five-year disease-free survival (DFS) was higher in the GR group than in the PR group (91.3% vs. 66.6%, p < 0.001). Patients with a GR and ypStage II disease had a five-year DFS that was indistinguishable from that of patients with ypStage 0–I disease (92.3% vs. 90.7%, p = 0.885). Likewise, patients with a GR and ypStage III disease had a five-year DFS similar to those with ypStage II disease (76.0% vs. 75.9%, p = 0.789). A new modified staging system that incorporates grouped TRG (GR vs. PR) was developed. The prognostic performance of this modified stage and the ypStage was compared with the Harrell C statistic. C statistic of the modified stage was higher than that of the ypStage (0.784 vs. 0.757, p = 0.012). The results remained robust after multivariate Cox regression analyses. In conclusion, a GR to neoadjuvant CRT is an independent predictor of good DFS and overall survival and further stratifies patients so as to estimate the risk of recurrence and survival among patients with ypStage II and III rectal cancer.
RETRACTED: Gao et al. Exploration of Growth Window for Phase-Pure Cubic Boron Nitride Films Prepared in a Pure N2 Plasma. Coatings 2018, 8, 82
Authors:   Coatings Editorial Office
Published: September 2018

The published article [1] has been retracted at the request of the corresponding author due to a dispute regarding the authorship of the paper[...]
Effect of an Edible Coating Based on Chitosan and Oxidized Starch on Shelf Life of Carica papaya L., and Its Physicochemical and Antimicrobial Properties
Authors: Escamilla-García Monserrat , Rodríguez-Hernández María J. , Hernández-Hernández Hilda M. , Delgado-Sánchez Luis F. , García-Almendárez Blanca E. , Amaro-Reyes Aldo , Regalado-González Carlos
Published: September 2018

Papaya production plays an important economic role in Mexico’s economy. After harvest, it continues to ripen, leading to softening, skin color changes, development of strong aroma, and microbial spoilage. The objective of this work was to apply an active coating of chitosan–starch to increase papaya shelf life and to evaluate physicochemical and antimicrobial properties of the coating. Papaya surfaces were coated with a chitosan-oxidized starch (1:3 w/w) solution and stored at room temperature (25 ± 1 °C) for 15 days. Variables measured were color, titratable acidity, vitamin C, pH, soluble solids, volatile compounds by gas chromatography, texture, homogeneity by image analysis, and coating antimicrobial activity. At the end of the storage time, there were no significant differences (p > 0.05) between coated and uncoated papayas for pH (4.3 ± 0.2), titratable acidity (0.12% ± 0.01% citric acid), and soluble solids (12 ± 0.2 °Bx). Papaya firmness decreased to 10 N for coated and 0.5 N for uncoated papayas. Volatile compounds identified in uncoated papaya (acetic acid, butyric acid, ethyl acetate, ethyl butanoate) are related to fermentation. Total microbial population of coated papaya decreased after 15 days, whereas population of uncoated papaya increased. This active coating permitted longer shelf life of papaya than that of the uncoated fruit.
Evaporation Boundary Conditions for the Linear R13 Equations Based on the Onsager Theory
Authors: Beckmann Alexander Felix , Rana Anirudh Singh , Torrilhon Manuel , Struchtrup Henning
Published: September 2018

Due to the failure of the continuum hypothesis for higher Knudsen numbers, rarefied gases and microflows of gases are particularly difficult to model. Macroscopic transport equations compete with particle methods, such as the Direct Simulation Monte Carlo method (DSMC), to find accurate solutions in the rarefied gas regime. Due to growing interest in micro flow applications, such as micro fuel cells, it is important to model and understand evaporation in this flow regime. Here, evaporation boundary conditions for the R13 equations, which are macroscopic transport equations with applicability in the rarefied gas regime, are derived. The new equations utilize Onsager relations, linear relations between thermodynamic fluxes and forces, with constant coefficients, that need to be determined. For this, the boundary conditions are fitted to DSMC data and compared to other R13 boundary conditions from kinetic theory and Navier–Stokes–Fourier (NSF) solutions for two one-dimensional steady-state problems. Overall, the suggested fittings of the new phenomenological boundary conditions show better agreement with DSMC than the alternative kinetic theory evaporation boundary conditions for R13. Furthermore, the new evaporation boundary conditions for R13 are implemented in a code for the numerical solution of complex, two-dimensional geometries and compared to NSF solutions. Different flow patterns between R13 and NSF for higher Knudsen numbers are observed.
Einstein-Podolsky-Rosen Steering Inequalities and Applications
Authors: Yang Ying , Cao Huaixin
Published: September 2018

Einstein-Podolsky-Rosen (EPR) steering is very important quantum correlation of a composite quantum system. It is an intermediate type of nonlocal correlation between entanglement and Bell nonlocality. In this paper, based on introducing definitions and characterizations of EPR steering, some EPR steering inequalities are derived. With these inequalities, the steerability of the maximally entangled state is checked and some conditions for the steerability of the X -states are obtained.
Wireless Power Transfer for Battery Powering System
Authors: Wang Tianfeng , Liu Xin , Jin Nan , Tang Houjun , Yang Xijun , Ali Muhammad
Published: September 2018

The LCL topology (formed by an LC tank with a transmitting coil) is extensively utilized in wireless power transfer (WPT) systems with the features of a constant resonant current and ability to disconnect load abruptly. However, it requires high input voltage, which limits its utilization in battery powering scenarios (12~24 V). A current-fed inverter (CFI) is applied to the LCL-S (a compensation capacitor in series with the receiving coil) WPT systems to boost the input voltage, thereby getting a higher resonant current in the transmitting side (Tx). To facilitate the voltage regulation in the receiving side (Rx), a semi-active bridge (SAB) is introduced into the system, which further boosts the output voltage by a lower frequency switching at different duty ratios. Rigorous mathematical analysis of the proposed system is carried out and design guidelines are subsequently derived. Moreover, a power loss reduction is realized by zero voltage switch (ZVS) of the four switches in the Tx which are deduced and presented. Simulations and experiments are added to verify the proposed system. Consequently, a 93.3% system efficiency (DC-to-DC efficiency) is obtained using the proposed topology. Optimization techniques for a higher efficiency are included in this study.
Cyclic Assessment of Magnesium Oxide with Additives as a Thermochemical Material to Improve the Mechanical Strength and Chemical Reaction
Authors: Yim Taesu , Kim Hong Soo , Lee Jae Yong
Published: September 2018

Heat storage with a thermochemical reaction has the advantages of a high heat storage density and no heat loss compared to conventional methods such as the sensible and latent heat. This method is promising to use in a thermal energy network because it is an efficient solution which addresses the time mismatch problem with regard to heat production and consumption. In this paper, we investigated Magnesium oxide (MgO) with different additives as a thermochemical material (TCM) coupled with the effects of several additives in an effort to improve the structural strength and reaction rate and reduce the initiation time. As additives in an MgO composite, Bentonite, Magnesium sulfate (MgSO4), and Zeolite 13X were chosen. With a cyclic scheduling experimental setup for the heat charging and discharging of the MgO composites, Bentonite as an additive improved the structural strength, and Zeolite 13X enhanced the reaction rate and led to faster reactions compared to only MgO as a TCM. With MgSO4 as an additive, however, the TCM composite showed a high reactivity during the a few cycles, and then rapidly became inactive due to byproducts side reaction. The results indicated that Bentonite and Zeolite additives, in an MgO composite, as a TCM can improve the mechanical strength and chemical reaction, optimum ratio is necessary to compromise promoting the thermochemical reaction.
Novel Design Support Methodology Based on a Multi-Criteria Decision Analysis Approach for Energy Efficient District Retrofitting Projects
Authors: García-Fuentes Miguel Á. , García-Pajares Rubén , Sanz Cecilia , Meiss Alberto
Published: September 2018

Districts can be considered as a system of complex interconnections, interactions, relationships and flows. Therefore, a comprehensive approach is essential for effective decision-making with regards to energy efficiency improvement. When addressing interventions with a wider scale, the range of possible interventions is greater, as well as the possibilities of new business models to make bankable the interventions. However certain barriers can appear linked to the interactions among stakeholders, which are usually more complex than when tackling individual actuations. To overcome these barriers it is necessary to establish integrated and systemic methodologies able to support stakeholders to implement better collaboration approaches and carry out more informed decisions. These decisions should be based on a set of relevant indicators, calculated at district level, capturing the different stages that form the retrofitting process (from the diagnosis to the final assessment). This paper presents a holistic design methodology based on the application of a Multi-Criteria Decision Making approach that allows designing optimised solutions. This methodology is based on the evaluation of a set of District Sustainability Indicators while proposing an Integrated Project Delivery method improving the communications among stakeholders and, therefore, the decision-making process.
The Management of Hazardous Solid Waste in India: An Overview
Authors: Karthikeyan Leelavathy , Suresh Venkatesan Madha , Krishnan Vignesh , Tudor Terry , Varshini Vedha
Published: September 2018

Due largely to economic development, industrialization, and changing lifestyles, quantity of hazardous waste in India is rising significantly. This is particularly true in mega cities, where populations are large and growing. Due to a range of factors including limitations in governance systems, inadequate treatment facilities, limitations in compliance and regulation, and limited trained and skilled stakeholders, the management of hazardous solid waste in the country is largely ineffective. One exception to this is the State of Gujarat, which has sought to implement a number of strategies to better manage the rising quantities of hazardous solid waste being produced. This article highlights the management of solid waste in the country for an effective mitigation of various hazards. Further, this article focused on adaptive technologies for the hazardous waste management all over the country more specifically in the state of Gujarat.
An Overview of Dynamic Heterogeneous Oxidations in the Troposphere
Authors: Pillar-Little Elizabeth A. , Guzman Marcelo I.
Published: September 2018

Due to the adverse effect of atmospheric aerosols on public health and their ability to affect climate, extensive research has been undertaken in recent decades to understand their sources and sinks, as well as to study their physical and chemical properties. Atmospheric aerosols are important players in the Earth’s radiative budget, affecting incoming and outgoing solar radiation through absorption and scattering by direct and indirect means. While the cooling properties of pure inorganic aerosols are relatively well understood, the impact of organic aerosols on the radiative budget is unclear. Additionally, organic aerosols are transformed through chemical reactions during atmospheric transport. The resulting complex mixture of organic aerosol has variable physical and chemical properties that contribute further to the uncertainty of these species modifying the radiative budget. Correlations between oxidative processing and increased absorptivity, hygroscopicity, and cloud condensation nuclei activity have been observed, but the mechanisms behind these phenomena have remained unexplored. Herein, we review environmentally relevant heterogeneous mechanisms occurring on interfaces that contribute to the processing of aerosols. Recent laboratory studies exploring processes at the aerosol–air interface are highlighted as capable of generating the complexity observed in the environment. Furthermore, a variety of laboratory methods developed specifically to study these processes under environmentally relevant conditions are introduced. Remarkably, the heterogeneous mechanisms presented might neither be feasible in the gas phase nor in the bulk particle phase of aerosols at the fast rates enabled on interfaces. In conclusion, these surface mechanisms are important to better understand how organic aerosols are transformed in the atmosphere affecting the environment.
Role of Homologous Recombination Genes in Repair of Alkylation Base Damage by Candida albicans
Authors: Ciudad Toni , Bellido Alberto , Andaluz Encarnación , Hermosa Belén , Larriba Germán
Published: September 2018

Candida albicans mutants deficient in homologous recombination (HR) are extremely sensitive to the alkylating agent methyl-methane-sulfonate (MMS). Here, we have investigated the role of HR genes in the protection and repair of C. albicans chromosomes by taking advantage of the heat-labile property (55 °C) of MMS-induced base damage. Acute MMS treatments of cycling cells caused chromosome fragmentation in vitro (55 °C) due to the generation of heat-dependent breaks (HDBs), but not in vivo (30 °C). Following removal of MMS wild type, cells regained the chromosome ladder regardless of whether they were transferred to yeast extract/peptone/dextrose (YPD) or to phosphate buffer saline (PBS); however, repair of HDB/chromosome restitution was faster in YPD, suggesting that it was accelerated by metabolic energy and further fueled by the subsequent overgrowth of survivors. Compared to wild type CAI4, chromosome restitution in YPD was not altered in a Carad59 isogenic derivative, whereas it was significantly delayed in Carad51 and Carad52 counterparts. However, when post-MMS incubation took place in PBS, chromosome restitution in wild type and HR mutants occurred with similar kinetics, suggesting that the exquisite sensitivity of Carad51 and Carad52 mutants to MMS is due to defective fork restart. Overall, our results demonstrate that repair of HDBs by resting cells of C. albicans is rather independent of CaRad51, CaRad52, and CaRad59, suggesting that it occurs mainly by base excision repair (BER).
Phosphorylation-Dependent Inhibition of Akt1
Authors: Balasuriya Nileeka , McKenna McShane , Liu Xuguang , Li Shawn S. C. , O’Donoghue Patrick
Published: September 2018

Protein kinase B (Akt1) is a proto-oncogene that is overactive in most cancers. Akt1 activation requires phosphorylation at Thr308; phosphorylation at Ser473 further enhances catalytic activity. Akt1 activity is also regulated via interactions between the kinase domain and the N-terminal auto-inhibitory pleckstrin homology (PH) domain. As it was previously difficult to produce Akt1 in site-specific phosphorylated forms, the contribution of each activating phosphorylation site to auto-inhibition was unknown. Using a combination of genetic code expansion and in vivo enzymatic phosphorylation, we produced Akt1 variants containing programmed phosphorylation to probe the interplay between Akt1 phosphorylation status and the auto-inhibitory function of the PH domain. Deletion of the PH domain increased the enzyme activity for all three phosphorylated Akt1 variants. For the doubly phosphorylated enzyme, deletion of the PH domain relieved auto-inhibition by 295-fold. We next found that phosphorylation at Ser473 provided resistance to chemical inhibition by Akti-1/2 inhibitor VIII. The Akti-1/2 inhibitor was most effective against pAkt1T308 and showed four-fold decreased potency with Akt1 variants phosphorylated at Ser473. The data highlight the need to design more potent Akt1 inhibitors that are effective against the doubly phosphorylated and most pathogenic form of Akt1.
Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews
Authors: Gu Sheng , Li Hui , Pakstis Andrew , Speed William , Gurwitz David , Kidd Judith , Kidd Kenneth
Published: September 2018

The derived human alcohol dehydrogenase (ADH)1B*48His allele of the ADH1B Arg48His polymorphism (rs1229984) has been identified as one component of an East Asian specific core haplotype that underwent recent positive selection. Our study has been extended to Southwest Asia and additional markers in East Asia. Fst values (Sewall Wright’s fixation index) and long-range haplotype analyses identify a strong signature of selection not only in East Asian but also in Southwest Asian populations. However, except for the ADH2B*48His allele, different core haplotypes occur in Southwest Asia compared to East Asia and the extended haplotypes also differ. Thus, the ADH1B*48His allele, as part of a core haplotype of 10 kb, has undergone recent rapid increases in frequency independently in the two regions after divergence of the respective populations. Emergence of agriculture may be the common factor underlying the evident selection.
Sepsis: Personalized Medicine Utilizing ‘Omic’ Technologies—A Paradigm Shift?
Authors: Itenov Theis Skovsgaard , Murray Daniel D. , Jensen Jens Ulrik Stæhr
Published: September 2018

Sepsis has over the years proven a considerable challenge to physicians and researchers. Numerous pharmacological and non-pharmacological interventions have been tested in trials, but have unfortunately failed to improve the general prognosis. This has led to the speculation that the sepsis population may be too heterogeneous to be targeted with the traditional one treatment suits all’ approach. Recent advances in genetic and biochemical analyses now allow genotyping and biochemical characterisation of large groups of patients via the ‘omics’ technologies. These new opportunities could lead to a paradigm shift in the approach to sepsis towards personalised treatments with interventions targeted towards specific pathophysiological mechanisms activated in the patient. In this article, we review the potentials and pitfalls of using new advanced technologies to deepen our understanding of the clinical syndrome of sepsis.
The Effect of Nordic Walking Training Combined with Vitamin D Supplementation on Postural Control and Muscle Strength in Elderly People—A Randomized Controlled Trial
Authors: Mieszkowski Jan , Niespodziński Bartłomiej , Kochanowicz Andrzej , Gmiat Anna , Prusik Krzysztof , Prusik Katarzyna , Kortas Jakub , Ziemann Ewa , Antosiewicz Jędrzej
Published: September 2018

Nordic Walking (NW) and Vitamin D concentration (Vit D) alone have been shown to contribute to the health and performance of elderly people. However, the interaction between these two factors has yet to be explored. In this study 42 women over 60 years of age (69.02 ± 5.56 years) were recruited and divided in two NW groups: a high-intensity interval training group (HI-NW) and a moderate-intensity continuous training group (MI-NW). Individuals from each group completed a 12-week NW training program (3 times a week/2 hours) combined with randomized Vitamin D supplementation (HD = high dose: 4000 IU/day or LD = low dose: 800 IU/day). Body composition, postural control, muscle strength and Vitamin D serum concentration were measured twice; before and after the intervention. To investigate the interaction between supplementation and training a mixed-design analysis of variance (ANOVA) was performed. The HI-NW group, regardless of supplementation dose, increased their Vit D and elbow torque performance. On the other hand, in the MI-NW group the same Vit D outcome was seen only with HD supplementation and was also associated with increased leg muscle mass. In conclusion, beneficial effects of both HI-NW and MI-NW training regimes were seen. The impact of the dose supplementation on Vit D and body composition was related to the type of NW training.
Work Related Stress, Well-Being and Cardiovascular Risk among Flight Logistic Workers: An Observational Study
Authors: Lecca Luigi Isaia , Campagna Marcello , Portoghese Igor , Galletta Maura , Mucci Nicola , Meloni Michele , Cocco Pierluigi
Published: September 2018

Work-related stress is a known occupational hazard, with a putative role on the development of cardiovascular diseases (CVD). Although several investigations have explored the association in various workplace scenarios, none have focused on the airport flight logistic support personnel, a transportation business of crucial importance, potentially exposed to job stress and consequently to an increase in CVD risk. We explored the relationship between work-related stress and cardiovascular risk in 568 healthy workers of a flight logistic support company using the Health and Safety Executive questionnaire, the Framingham Heart Study General Cardiovascular Disease (CVD) Risk Prediction Score, and the WHO general well-being index (WHO-5). We used univariate and multivariate statistical methods to take account of possible confounders. Our results show that a low job support significantly increases the CVD risk score and decreases the WHO well-being index with reference to subjects reporting high support on the job. In addition, the well-being index of workers with high strain jobs appears lower in respect to workers employed in low strain job. The multivariate analysis confirms a protective effect of job support, and shows a detrimental influence on CVD risk by physical inactivity, regular intake of alcohol, and a low educational level. In addition, job control, job support, low strain, and high demand coupled with high control (active job) showed a beneficial effect on psychological well-being. Our results suggest that a combination of general risk factors and organizational factors contributes to increase CVD risk and well-being, representing a crucial target for intervention strategies to promote health in the workplace.
Nonlinear Granger Causality between Health Care Expenditure and Economic Growth in the OECD and Major Developing Countries
Authors: Ye Liping , Zhang Xinping
Published: September 2018

Differing from previous studies ignoring the nonlinear features, this study employs both the linear and nonlinear Granger causality tests to examine the complex causal relationship between health care expenditure and economic growth among 15 Organisation for Economic Co-operation and Development (OECD) and 5 major developing countries. Some interesting findings can be obtained as follows: (1) For Australia, Austria, and UK, linear and nonlinear Granger causality does not exist between them. A unidirectional linear or nonlinear causality running from economic growth to health care expenditure can be found for Ireland, Korea, Portugal, and India. For these seven countries, health or fiscal policy related to health spending will not have an impact on economic growth; (2) For Belgium, Norway, and Mexico, only a unidirectional linear causality runs from health care expenditure to economic growth, while bidirectional linear causality can be found for Canada, Finland, Iceland, New Zealand, Spain, Brazil, and South Africa. Especially for the US, China, and Japan, a unidirectional nonlinear causality exists from health spending to economic growth. To improve the quality of national health, life quality and happiness, these 13 countries should actively look to optimise policy related to health care expenditure, such as by enhancing the efficiency of health costs to promote sustainable economic development.
Relationship between Photosynthetic Capacity and Microcystin Production in Toxic Microcystis Aeruginosa under Different Iron Regimes
Authors: Wang Xun , Wang Peifang , Wang Chao , Qian Jin , Feng Tao , Yang Yangyang
Published: September 2018

Blooms of harmful cyanobacteria have been observed in various water bodies across the world and some of them can produce intracellular toxins, such as microcystins (MCs), which negatively impact aquatic organisms and human health. Iron participates significantly in cyanobacterial photosynthesis and is proposed to be linked to MC production. Here, the cyanobacteria Microcystis aeruginosa was cultivated under different iron regimes to investigate the relationship between photosynthetic capacity and MC production. The results showed that iron addition increased cell density, cellular protein concentration and the Chl-a (chlorophyll-a) content. Similarly, it can also up–regulate photosynthetic capacity and promote MC–leucine–arginine (MC–LR) production, but not in a dose–dependent manner. Moreover, a significant positive correlation between photosynthetic capacity and MC production was observed, and electron transport parameters were the most important parameters contributing to the variation of intracellular MC–LR concentration revealed by Generalized Additive Model analysis. As the electron transport chain was affected by iron variation, adenosine triphosphate production was inhibited, leading to the alteration of MC synthetase gene expression. Therefore, it is demonstrated that MC production greatly relies on redox status and energy metabolism of photosynthesis in M. aeruginosa. In consequence, more attention should be paid to the involvement of photosynthesis in the regulation of MC production by iron variation in the future.
Reducing Stress and Promoting Social Integration of International Medical Students through a Tandem Program: Results of a Prospective-Program Evaluation
Authors: Herrmann-Werner Anne , Junne Florian , Stuber Felicitas , Huhn Daniel , Nikendei Christoph , Seifried-Dübon Tanja , Zipfel Stephan , Erschens Rebecca
Published: September 2018

Medical students, and especially international medical students (IMS), have been shown to experience more psychological distress than the general student population in Germany. In order to address these issues, a structured Tandem Program (TP) to reduce stress and foster social integration of IMS has been introduced at the Medical Faculty of Tuebingen. The Tandem Program was evaluated prospectively with perceived stress (PSQ-20) as the main outcome. Secondary outcomes were ‘motives to participate’ in the TP, ‘specific stressors’, and ‘experiences made’ during the program. Stress levels of IMS at the beginning of the program (t0) (M = 48.14, SD = 11.95) were higher than those of German participants (M = 39.33, SD = 8.31) (t (67) = −3.66, p < 0.001). At the end of the TP (t1), stress levels of international students were significantly lower than at t0. “Improved ability to work in a team” was seen as one of the most beneficial factors. The results indicate that tandem programs at medical faculties may be a promising curricular intervention towards reducing stress levels, improving integration of international students, and to enhance intercultural and team-oriented competencies in both international and national medical students.
Removal Characteristics of N-Nitrosamines and Their Precursors by Pilot-Scale Integrated Membrane Systems for Water Reuse
Authors: Takeuchi Haruka , Yamashita Naoyuki , Nakada Norihide , Tanaka Hiroaki
Published: September 2018

This study investigated the removal characteristics of N-Nitrosamines and their precursors at three pilot-scale water reclamation plants. These plants applies different integrated membrane systems: (1) microfiltration (MF)/nanofiltration (NF)/reverse osmosis (RO) membrane; (2) sand filtration/three-stage RO; and (3) ultrafiltration (UF)/NF and UF/RO. Variable removal of N-Nitrosodimethylamine (NDMA) by the RO processes could be attributed to membrane fouling and the feed water temperature. The effect of membrane fouling on N-Nitrosamine removal was extensively evaluated at one of the plants by conducting one month of operation and chemical cleaning of the RO element. Membrane fouling enhanced N-Nitrosamine removal by the pilot-scale RO process. This finding contributes to better understanding of the variable removal of NDMA by RO processes. This study also investigated the removal characteristics of N-Nitrosamine precursors. The NF and RO processes greatly reduced NDMA formation potential (FP), but the UF process had little effect. The contributions of MF, NF, and RO processes for reducing FPs of NDMA, N-Nitrosopyrrolidine and N-Nitrosodiethylamine were different, suggesting different size distributions of their precursors.
Critical Review of Methods to Estimate PM2.5 Concentrations within Specified Research Region
Authors: Zhang Guangyuan , Rui Xiaoping , Fan Yonglei
Published: September 2018

Obtaining PM2.5 data for the entirety of a research region underlies the study of the relationship between PM2.5 and human spatiotemporal activity. A professional sampler with a filter membrane is used to measure accurate values of PM2.5 at single points in space. However, there are numerous PM2.5 sampling and monitoring facilities that rely on data from only representative points, and which cannot measure the data for the whole region of research interest. This provides the motivation for researching the methods of estimation of particulate matter in areas having fewer monitors at a special scale, an approach now attracting considerable academic interest. The aim of this study is to (1) reclassify and particularize the most frequently used approaches for estimating the PM2.5 concentrations covering an entire research region; (2) list improvements to and integrations of traditional methods and their applications; and (3) compare existing approaches to PM2.5 estimation on the basis of accuracy and applicability.
Robotic Stereotactic Radiosurgery in Melanoma Patients with Brain Metastases under Simultaneous Anti-PD-1 Treatment
Authors: Trommer-Nestler Maike , Marnitz Simone , Kocher Martin , Rueß Daniel , Schlaak Max , Theurich Sebastian , Von Bergwelt-Baildon Michael , Morgenthaler Janis , Jablonska Karolina , Celik Eren , Ruge Maximilian I. , Baues Christian
Published: September 2018

Combination concepts of radiotherapy and immune checkpoint inhibition are currently of high interest. We examined imaging findings, acute toxicity, and local control in patients with melanoma brain metastases receiving programmed death 1 (PD-1) inhibitors and/or robotic stereotactic radiosurgery (SRS). Twenty-six patients treated with SRS alone (n = 13; 20 lesions) or in combination with anti-PD-1 therapy (n = 13; 28 lesions) were analyzed. Lesion size was evaluated three and six months after SRS using a volumetric assessment based on cranial magnetic resonance imaging (cMRI) and acute toxicity after 12 weeks according to the Common Terminology Criteria for Adverse Events (CTCAE). Local control after six months was comparable (86%, SRS + anti-PD-1, and 80%, SRS). All toxicities reported were less than or equal to grade 2. One metastasis (5%) in the SRS group and six (21%) in the SRS + anti-PD-1 group increased after three months, whereas four (14%) of the six regressed during further follow-ups. This was rated as pseudoprogression (PsP). Three patients (23%) in the SRS + anti-PD-1 group showed characteristics of PsP. Treatment with SRS and anti-PD-1 antibodies can be combined safely in melanoma patients with cerebral metastases. Early volumetric progression of lesions under simultaneous treatment may be related to PsP; thus, the evaluation of combined radioimmunotherapy remains challenging and requires experienced teams.
Proteomics Analysis Reveals Non-Controlled Activation of Photosynthesis and Protein Synthesis in a Rice npp1 Mutant under High Temperature and Elevated CO2 Conditions
Authors: Inomata Takuya , Baslam Marouane , Masui Takahiro , Koshu Tsutomu , Takamatsu Takeshi , Kaneko Kentaro , Pozueta-Romero Javier , Mitsui Toshiaki
Published: September 2018

Rice nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) catalyzes the hydrolytic breakdown of the pyrophosphate and phosphodiester bonds of a number of nucleotides including ADP-glucose and ATP. Under high temperature and elevated CO2 conditions (HT + ECO2), the npp1 knockout rice mutant displayed rapid growth and high starch content phenotypes, indicating that NPP1 exerts a negative effect on starch accumulation and growth. To gain further insight into the mechanisms involved in the NPP1 downregulation induced starch overaccumulation, in this study we conducted photosynthesis, leaf proteomic, and chloroplast phosphoproteomic analyses of wild-type (WT) and npp1 plants cultured under HT + ECO2. Photosynthesis in npp1 leaves was significantly higher than in WT. Additionally, npp1 leaves accumulated higher levels of sucrose than WT. The proteomic analyses revealed upregulation of proteins related to carbohydrate metabolism and the protein synthesis system in npp1 plants. Further, our data indicate the induction of 14-3-3 proteins in npp1 plants. Our finding demonstrates a higher level of protein phosphorylation in npp1 chloroplasts, which may play an important role in carbohydrate accumulation. Together, these results offer novel targets and provide additional insights into carbohydrate metabolism regulation under ambient and adverse conditions.
Genome-Wide Analysis Elucidates the Role of CONSTANS-like Genes in Stress Responses of Cotton
Authors: Qin Wenqiang , Yu Ya , Jin Yuying , Wang Xindong , Liu Ji , Xi Jianping , Li Zhi , Li Huiqin , Zhao Ge , Hu Wei , Chen Chuanjia , Li Fuguang , Yang Zhaoen
Published: September 2018

The CONSTANS (CO)-like gene family has been well studied for its role in the regulation of plant flowering time. However, their role remains poorly understood in cotton. To better understand the possible roles of CO-like in cotton, we performed a comprehensive genome-wide analysis of CO-like genes in cotton. Phylogenetic tree analysis showed that CO-like genes naturally clustered into three groups. Segmental duplication and whole genome duplication (WGD), which occurred before polyploidy, were important contributors to its expansion within the At (“t” indicates tetraploid) and Dt subgenomes, particularly in Group III. Long-terminal repeat retroelements were identified as the main transposable elements accompanying 18 genes. The genotype of GhCOL12_Dt displayed low diversity; it was a candidate involved in domestication. Selection pressure analyses indicated that relaxed purifying selection might have provided the main impetus during the evolution of CO-like genes in upland cotton. In addition, the high expression in the torus and calycle indicated that CO-like genes might affect flowering. The genes from Group II, and those from Group III involved in segmental duplication or WGD, might play important roles in response to drought and salt stress. Overall, this comprehensive genome-wide study of the CO-like gene family would facilitate further detailed studies in cotton.
Negative Cellular Effects of Urban Particulate Matter on Human Keratinocytes Are Mediated by P38 MAPK and NF-κB-dependent Expression of TRPV 1
Authors: Kwon Kitae , Park See-Hyoung , Han Byung Seok , Oh Sae Woong , Lee Seung Eun , Yoo Ju Ah , Park Se Jung , Kim Jangsoon , Kim Ji Woong , Cho Jae Youl , Lee Jongsung
Published: September 2018

Urban particulate matter (UPM) exerts negative effects on various human organs. Transient receptor potential vanilloid 1 (TRPV1) is a polymodal sensory transducer that can be activated by multiple noxious stimuli. This study aimed to explore the effects of the UPM 1648a on the expression of TRPV1, and its regulatory mechanisms in HaCaT cells. UPM enhanced TRPV 1 promoter-luciferase reporter activity. UPM also increased expression of the TRPV 1 gene as evidenced by increased mRNA and protein levels of TRPV 1. In addition, elucidation of the underlying mechanism behind the UPM-mediated effects on TRPV 1 expression revealed that UPM can upregulate expression of the TRPV1 gene by activating activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). The UPM treatment also altered Ca2+ influx and cell proliferation, as well as production of interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). In addition, these UPM-induced effects were attenuated by SB203580 and ammonium pyrrolidinedithiocarbamate (PDTC). However, SP600125 and PD98059 did not alter the UPM-induced effects. Taken together, these findings indicate that UPM upregulates expression of the TRPV 1 gene, which is mediated by the p38 mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways and suggest that UPM is a potential irritant that can induce skin processes such as aging and inflammatory responses.