bluuebunny/crossref_metadata_2025 huggingface dataset:
The systemic factors of mitigating the contribution of the reversible phenotypic transitions of malignant cells to therapeutic resistance
Authors: Голубев Алексей , Анисимов Владимир
Published: December 2022

Анализ литературы, имеющей отношение к фенотипической пластичности трансформированных клеток при развитии резистентности опухолей к терапии, привел с учетом основных характеристик эпителиального, мезенхимального, стволового и сенесцентного состояний опухолевых клеток к выводу, что ключевым фактором терапевтической резистентности является обратимость переходов между этими состояниями. Молекулярные механизмы таких переходов могут включать стохастические переключения активных генов между участием и неучастием в транскрипции. Кинетика переходов и соответствующее равновесие между разными фенотипическими состояниями существенно зависят от среды, где это происходит, а значит от возраста опухоленосителя и от его гормонально-метаболического статуса. Таким образом, воздействия на метаболические параметры организма могут влиять на эффективность противоопухолевой терапии без изменений жизнеспособности и пролиферации опухолевых клеток в любом из возможных для них состояний. С таких позиций рассмотрены данные о противоопухолевых эффектах антидиабетических бигуанидов. Сделан вывод, что, если анализировать в терминах обратимости фенотипических состояний трансформированных клеток противоопухолевые эффекты воздействий, цитотоксические или цитостатические последствия которых неочевидны, это может не только помочь в понимании того, каким образом такие воздействия могут влиять на опухоли, но и расширить круг критериев для поисков новых противораковых средств.
Validation of preoperative diagnosis of malignant thyroid tumors using a molecular classifier
Authors: Титов Сергей , Лукьянов Сергей , Козорезова Евгения , Деменков Павел , Сергийко Сергей , Веряскина Юлия , Воробьев Сергей , Слепцов Илья , Гостимский Александр
Published: December 2022

Введение. Тонкоигольная аспирационная биопсия (ТАБ) узлов щитовидной железы под УЗ-контролем с последующим цитологическим исследованием является основным способом оценки риска злокачественности этих образований. При этом неопределенные и подозрительные на опухоль цитологические заключения (Bethesda III, IV) являются показанием для направления пациентов на оперативное лечение, в части случаев избыточное. Анализ молекулярных маркеров в материале ТАБ в дополнение к цитологическому исследованию ― многообещающий способ улучшения предоперационной диагностики узлов щитовидной железы.
Целью исследования стало повышение точности дооперационной диагностики опухолей щитовидной железы.
Материалы и методы. В данной работе на основании ретроспективного многоцентрового слепого исследования проведена валидация диагностических возможностей отечественного молекулярно-генетического теста (МГТ), разработанного для дифференциальной диагностики опухолей щитовидной железы. Тест основан на оценке относительных уровней экспрессии генов GCM2 и HMGA2, уровней микроРНК-146b, -221, -375, -31 и -551b, соотношения митохондриальной и ядерной ДНК, а также определение соматической мутации V600E в гене BRAF. Анализировано 329 цитологических образцов, из них: 22 (6,7%) с заключением Bethesda II, 226 (68,7%) Bethesda IV, 6 (1,8%) Bethesda V и 75 (22,8%) Bethesda VI.
Результаты. В нашем исследовании получились следующие диагностические характеристики для выявления злокачественных опухолей молекулярным тестом: специфичность ― 90,8%, чувствительность ― 86,9%, положительная предсказательная ценность ― 82,3%, отрицательная предсказательная ценность ― 93,4%. При выявлении молекулярным тестом папиллярного рака общая точность — 96,6%, фолликулярного рака ― 94,4%, медуллярного рака ― 100%, Гюртлеклеточного рака ― 96,9%.
Заключение. Проведенное исследование демонстрирует возможность выявления и типирования опухолей щитовидной железы с помощью панели из небольшого числа молекулярных маркеров, выявляемых в цитологических препаратах с помощью ПЦР в реальном времени. Точность отечественного МГТ сопоставима с зарубежными аналогами.
PENGARUH MEDIA SOSIAL DAN LITERASI EKONOMI TERHADAP PERILAKU KONSUMTIF MAHASISWA PADA ONLINE SHOP
Authors: Ismawan Mitron Bayu , Pamungkas Heni Purwa
Published: December 2022

Perkembangan global mendorong transformasi kegiatan ekonomi ke dunia digital. Hal itu menjadikan banyak tersedianya bahan literatur ekonomi berbasis digital dan pesatnya laju media sosial menciptakan aktivitas jual beli masyarakat beralih ke online shop. Penelitian ini memiliki tujuan untuk mengeksplorasi dampak penggunaan media sosial dan literasi ekonomi terhadap perilaku konsumtif mahasiswa. Penelitian ini menggunakan pendekatan kuantitatif dengan metode analisis regresi linier berganda dan melibatkan 368 mahasiswa Fakultas Ekonomi dan Bisnis UNESA sebagai responden. Penelitian ini mengungkapkan bahwa variabel media sosial (X1) tidak berpengaruh terhadap varibael perilaku konsumtif (Y), namun untuk variabel literasi ekonomi (X2) mempengaruhi variabel perilaku konsumtif  (Y). Kemudian variabel media sosial (X1) dan literasi ekonomi (X2) mempengaruhi secara simultan dan bersama-sama pada variabel perilaku konsumtif (Y), dan nilai R Square menunjukkan bahwa pengaruh secara bersamaan X1 dan X2 sebesar 10,5% terhadap variabel Y. Dari hasil penelitian ini memberikan referensi untuk dapat memanajerial kegiatan ekonomi di era digital dan media sosial memberikan ruang lebih untuk meningkatkan literasi ekonomi.
The Principle of Material Unity of the World in the World of Pluralism
Authors:   Perm State National Research University, Porosenkov Sergey V.
Published: December 2022

This paper dwells on the principle of material unity of the world in the aspects of substantial, substrate, attributive, and functional unity of the world and in the aspect of unity of the world’s natural process. A substantial connection of this principle with the development of science, primarily, natural sciences, is determined. A historical nature of philosophical interpretations of the principle of material unity of the world is identified and a comparison is drawn between the monistic expression of this principle based on classical scientific rationality and its interpretations based on non-classical scientific rationality. A conclusion is made about the impact of methodological pluralism of modern scientific cognition on various substantive aspects of the principle of material unity of the world. Points of contradiction are identified between the modern scientific methodologies and the philosophical content of the principle under study. In terms of the ideological significance of the principle of material unity of the world, the author points out complete exclusion of the ontological meaning of any religious views and ideas by the regulatory action of this principle. In the modern picture of worldview pluralism (dominated by religious and religious-like beliefs, value orientations and views) a worldview based on the principle of material unity of the world is elitist and is very poorly represented. In scientists’ worldview, orientation towards this principle explicitly (reflexively) or implicitly performs the function of an epistemological basis for extrapolating knowledge obtained in local areas of research to the entire subject area of the relevant sciences. Therefore, at least within the scientific community, the principle of material unity of the world retains its monistic significance, both in methodological and ideological terms.
On the Question of Author and Hero in M.M. Bakhtin’s Philosophical Anthropology of the Early Period
Authors:   Perm National Research Polytechnic University, Politov Andrey V. , Zheleznyak Vladimir N.
Published: December 2022

This article is an ontological and existential interpretation of Mikhail Bakhtin’s early works (Art and Answerability; Toward a Philosophy of the Act; Author and Hero in Aesthetic Activity), containing a deep philosophical-anthropological and innovative, in historical and philosophical terms, dialectic of author and hero. The study suggests that during his years in Nevel and Vitebsk Bakhtin strove for an ontological and ethical deepening of the aesthetics of verbal creativity, asserting (in the ontological plane) the being of the hero and, accordingly, the ontological status of the author and the literary work. Unlike with being (an objectively outside position), it is possible to argue with the “author” (a subjectively involved position); the existing (genuine) author is present in the literary work in the form of events that are transgredient (out-of-reach) to the hero’s consciousness. While a hero’s life unfolds as a sequence of actions, the real author is hidden in the hero’s fate (in fact, his own fate) and must be responsible for him. In order to embrace his life in a holistic event, an individual needs to “disappear” as a psychological subject in the practical procedure of ontological conversion of consciousness and relate himself to the moments of his life that are transgredient to his personality. The sum of such moments can be called human destiny. In order to be a full-ledged, real author for the hero, the “subject” must become an author for himself (regardless of whether he is going to become an artist or not). As a result, an objective ontological and existential situation arises, in which the hero and the author undergo an ontological and aesthetic conversion (neutralization of bad subjectivity).
Verbal Means of Communicative Contact in Modern Russian
Authors:   A.P. Chekhov Institute (Branch) in Taganrog, Rostov State University of Economics, Murashova Evgeniya A. , Polenova Galina T.
Published: December 2022

The central task of this article was to describe the nomenclature of multi-level verbal means that serve to establish, transform and maintain verbal interaction. From the standpoint of the integrativecomparative approach being developed, the paper outlines the integral and differential features of these verbal means as components of the system of pragmatically valent contactives of the modern Russian language. As the main research method, a comprehensive corpus-contextual analysis was used, providing objectivity and a possibility of verifying the desired results. Dominant and peripheral zones were identified, specific hierarchical relationships of their actualization in texts were established, and the structure and part-of-speech affiliation of contactives were analysed. This determines the novelty and practical significance of the paper, which expands the base of theoretical and methodological information about the system of such verbal means as contactives by filling in the gaps in modern linguistic knowledge in the range of detecting universal and specific ways of manifestation of national-cultural and individual attitudes in the process of verbal interaction, as well as in understanding these verbal means as elements that identify specific features of the participants in communication. As the material for the study, we used texts from the National Corpus of the Russian Language, representing situations of establishing, transforming and maintaining verbal communication. The research proved (based on the material of a single national corpus, i.e. National Corpus of the Russian Language) the productivity of the integrative-comparative strategy in general and corpus-contextual analysis in particular in solving the problem of systematic description of verbal means that explicate the communicative situation in the totality of all its components.
Nation and Civilization: The Classical Distinctions
Authors:   Industrial University of Tyumen, Kasimov Ruslan Kh.
Published: December 2022

The theory of nation and the theory of civilization attract considerable attention in the field of political and social sciences as well as in philosophy. However, the categories of nation and civilization are usually regarded separately, due to the fact that these two approaches have developed independently. Key thinkers of the theory of nation, as a rule, either ignore the category of civilization or give it only formal attention. The leading figures of the theory of civilization, on the contrary, could not but consider the distinction between nation and civilization. It should be noted that the concept of civilization could only be constructed proceeding from the category of nation, which had acquired a normative status in the social disciplines as early as in the 19th century. This article dwells on the distinction between nation and civilization in the works of the classical theorists of civilization, namely, O. Spengler, A. Toynbee and S. Huntington. In spite of the fact that all of the above authors make this differentiation, it is only in the works of Toynbee and Huntington that nation and civilization are presented as commensurable. Toynbee distinguishes nation and civilization as a part and as a whole, recognizing the subjectivity of civilization. Huntington proposes a hybrid differentiation that both preserves the qualities of the classical theory of civilization and includes elements of constructivism. The latter forms the basis for non-classical theories of civilization, such as G. Therborn’s concept. The non-classical approach allows us to draw not only a quantitative, but also a qualitative distinction between nations and civilizations: while nation-states arise as a result of a break with the past and develop within the framework of modernity, civilizations continue and restore the tradition.
The Nature–Human–Culture Triad in the Geocultural Space Construction of the Russian North
Authors:   N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Usov Aleksey A.
Published: December 2022

This article presents the results of many years of research into the geocultural space of the Russian North, its figurative and symbolic framework. The conceptual and methodological foundations for studying the principles of constructing geocultural space as well as Russian and foreign theories of cultural landscape are considered. The paper presents the author’s theoretical nature–human–culture model, which elucidates the problem of overcoming the dialectical contradiction in understanding the Northern Russian space in terms of adaptation and spiritual transformation. The article reveals the ethnocultural meanings of the space (landscape) of the Russian North in the context of the nature–human–culture triad. The symbolic space is formed in the process of exploration and “appropriation” of the Northern territories, which is expressed in the acts of comprehension (of both the northern world and the place of the human in it) and expansion. The author concludes that the exploration of the Northern space is a critically intense process, where both poles of human life, spiritual and physical, are manifested to the fullest. Considering the dual nature of humans, the exploration of the Northern space takes place on two levels: material (physical) and spiritual. The result of such exploration is the cultural landscape, i.e. an element of the geocultural space in which a person acts both as a subject and as a measure of its potential development. In terms of practical significance, this paper solves the problem of actualization of the cultural landscapes of Northern Russia as a basic component of the country’s regional and national culture, as well as the problem of formation of sociocultural constants that determine the spatial coordinates of the socioeconomic development of the North. The scientific importance and relevance of this research lie in the need to reconstruct the geocultural and geohistorical images of the Russian North and Russian Arctic as a symbolic resource for the development of the Northern macroregion.
The Idea of the Overman in F. Nietzsche’s Philosophy: New Values Beyond Humanity
Authors:   University of London, Martin Ellen
Published: December 2022

In the light of the contemporary post-humanist discourse and tendency towards rejecting the idea of the subject in Western European philosophy, Nietzsche’s concept of the Übermensch (overman) appears to be an integral part of discussions on the anthropological limit and the transformation of human nature. This article considers Nietzsche’s main views on the need to reassess moral values during the devaluation of the Christian religion in Europe. The author analyses the concept of the will to power, which for Nietzsche is an internal energy, a necessary condition for the formation of new values. This is the essence of life. Through his idea of the overman, Nietzsche highlights the problem of cultural decadence in late 19thcentury Europe. In addition, the paper describes the views of W. Kaufmann, who called Nietzsche a philosopher-surgeon because he stressed the problem of moral degradation of European society. In Nietzsche’s philosophy, this ideological position is associated with the rejection of those values that he considered dead, as well as with an attempt to create new value orientations. The analysis of the image of Zarathustra allows us to conclude that the explication of the image of the overman reflects Nietzsche’s axiological ideal, which is based on a new understanding of human, established on the value orientations based on egocentrism, nihilism and the idea of will to power as the only condition for becoming. The author demonstrates that the underlying reason for the overman’s self-destruction is his belief that the world can exist without God. Idealizing the image of the overman is dangerous, as becoming an overman means overcoming human virtues, when, by crossing the boundaries of good and evil, the subject becomes able to create his/her own value orientations, which are incompatible with human virtues.
Questions of Text Composition
Authors:   Northern (Arctic) Federal University named after M.V. Lomonosov, Fedulenkova Tat’yana N.
Published: December 2022

The book under review is interesting in that it outlines the author’s approach to understanding the architectonics of a literary text. Based on a comparison of trends in world literature – from classical antiquity, through the Renaissance, to the late modern period – V.A. Kukharenko presents her vision of the literary text’s title, epigraph and structure as well as its varieties, such as simple and complex linear composition, frame composition, and composition according to the “matryoshka” principle. In addition, the author identifies the functions of the insert text and expresses some ingenuous ideas related to intertextuality.
KOMPETENSI KOMUNIKASI KEPALA SEKOLAH DALAM MENINGKATKAN KINERJA GURU SMK KARTIKA V-I BALIKPAPAN
Authors: Pps Jurnalpps , ÔÇÄ Harsono , Prasetyo Indra
Published: December 2022

Competence is a basic characteristic consisting of skill, knowledge and other personal attributes that distinguish someone from performing and not performing and is used as a determining tool to predict the success of improving teacher performance at SMK Kartika V-1 Balikpapan. School principals are needed to bridge teachers in Vocational School Kartika V-1 Balikpapan who have direct and indirect links with foundations, education supervisors, structural schools and school committees. The performance of a teacher can be seen from the work results of quality and quantity achieved in carrying out their duties in accordance with the responsibilities given to him. HR Performance is the work performance (output) both carrying out their work duties in accordance with the responsibilities given to them. Communication of school principals with the structural ranks of schools, foundations, education supervisors, school committees and teachers themselves can improve teacher performance so as to create harmonious and pleasant working relationships in the school environment
PENGARUH DISIPLIN DAN MOTIVASI TERHADAP KINERJA GURU DI SMP TAMAN DEWASA KOTA PROBOLINGGO
Authors: Pps Jurnalpps , Verawati Herlina Agus
Published: December 2022

The purpose of this study is to determine the effect of work discipline and work motivation on performance in the SMP Taman Dewasa in Probolinggo City. This research uses quantitative and takes a sample of 39 respondents, data collection methods using questionnaires and sampling techniques using census techniques. The analytical tool used was a questionnaire test consisting of a validity and reliability test, a classic assumption test, a multiple regression test, a determination test, a hypothesis test consisting of an F test, a t test and a dominant test. The results of the validity test show all valid question items above 0.316 and the results of the reliability test show the reliable results are above 0.60. Normality Test shows normally distributed data. Multicollinearity test shows the independent variable (X) and the dependent variable (Y) there is no correlation between the independent variables or the regression model free from multicollinearity. Heteroscedasticity test showed there was no heteroscedasticity. Autocorrelation test showed no autocorrelation. The t test showed that the work discipline variable (X1) had a partial effect.
PELAKSANAAN PENGEMBANGAN KARIR GURU DI SMK TI LABBAIKA SAMARINDA
Authors: Pps Jurnalpps , ÔÇÄ Kurniawan , Utari Woro
Published: December 2022

This study uses a qualitative descriptive approach because the symptoms of information or information from the observations during the research process indicate that this research occurs naturally and without any manipulation of existing circumstances and conditions. The focus and dimensions of research in this study are to describe the career development of SMK TI Labbaika Samarinda teachers, how the descriptions of SMK TI Labbaika Samarinda teachers, how the planning and constraints faced in the career development of IT Labbaika Samarinda Vocational School teachers. The results of the research after conducting interviews, observation and in-depth analysis.From the interview data presented with the informants, it shows that the planning and implementation of career development has been done in accordance with the guidance and career development of SMK TI Labbaika teachers, which are in accordance with the requirements of career planning, namely planning. it must suit organizational, individual and managerial.
PENGARUH KOMPETENSI KEPRIBADIAN DAN KECERDASAN EMOSIONAL TERHADAP KINERJA GURU SMP NEGERI 13 BALIKPAPAN
Authors: Pps Jurnalpps , Anggraini Wadi Reina , Hartati C. Sri , Utari Woro
Published: December 2022

This research is the result of research which describes how much personality competence and emotional intelligence have an effect on improving teacher performance at SMP Negeri 13 Balikpapan. The background of this research is because based on the results of observations it shows an increase from year to year, the achievement of SMP Negeri 13 Balikpapan both academically and non-academically is not optimal. After looking at several indicators, this study focuses on looking at the influence of personality competence and emotional intelligence on teacher performance at SMP Negeri 13 Balikpapan. This research uses quantitative research methods. The research subjects were all teachers who served at SMP Negeri 13 Balikpapan. The results showed that personality competence and emotional intelligence had a significant effect on teacher performance at SMP Negeri 13 Balikpapan.
PENGARUH KOMPETENSI, BUDAYA KERJA DAN KOMPENSASI TERHADAP KINERJA KARYAWAN HOME INDUSTRY KERUPUK SARIPATI SINGKONG DI KABUPATEN GRESIK
Authors: Pps Jurnalpps , SyafiÔÇÖuddin Muhammad , Prasetyo Indra
Published: December 2022

The purpose of this study was to determine and analyze the effect of competence, work culture and compensation on the performance of home industry employees of cassava crackers simultaneously and partially. To analyze the effect of competence, work culture and compensation on employee performance. The data analysis technique used multiple linear regression analysis. The results showed that simultaneously, all independent variables such as competence, work culture and compensation had a significant effect on employee performance. The influence given by the three independent variables is positive, meaning that the higher the competence, work culture and compensation simultaneously, the higher the employee's performance will be. Partially, the competency variable has no significant effect on employee performance. While the variables of work culture and compensation each have a significant effect on employee performance.
PENGARUH TANGGUNG JAWAB SOSIAL, PENGELOLAAN PENGETAHUAN DAN PENGELOLAAN SISTEM KERJA PEGAWAI TERHADAP KINERJA PEGAWAI DENGAN TATA KELOLA PERUSAHAANSEBAGAI VARIABEL INTERVENING
Authors: Pps Jurnalpps , Servanda Rizka Paramitha , Wibowo Nugroho Mardi
Published: December 2022

The purpose of this study was to determine the effect of social responsibility, knowledge management, management of employee work systems, corporate governance on employee performance in the field of medical supplies and equipment at RSUD Dr. Soetomo. The sample selection technique in this study was a census, namely all employees were taken as a sample of 45 employees. The data analysis technique used path analysis. The results of the study show that social responsibility has a significant effect on governance, knowledge management has a significant effect on governance, management of employee work systems has a significant effect on governance in the Medical Supplies and Equipment Sector of RSUD Dr. Soetomo. Employee social responsibility has a significant effect on employee performance, employee knowledge management has a significant effect on employee performance, employee knowledge management has a significant effect on employee performance in the Medical Supplies and Equipment Division of RSUD Dr. Soetomo. Employee governance has a significant effect on employee performance in the Medical Supplies and Equipment Division of RSUD Dr. Soetomo.
PENGARUH KOMPETENSI DAN PELATIHAN TERHADAP KINERJA GURU DENGAN MOTIVASI SEBAGAI VARIABEL INTERVENING DI SMK NAHDLATUL ULAMA BALIKPAPAN
Authors: Pps Jurnalpps , Santoso Heri , Utari Woro , Prasetyo Indra
Published: December 2022

Penelitian bertujuan untuk mengetahui, kompetensi, dan pelatihan terhadap kinerja guru dengan motivasi sebagai variabel intervening di SMK Nahdlatul Ulama Yayasan Pondok Pesantren Modern Al-Muttaqien. Penelitian ini merupakan penelitian kuantitatif, menggunakan analisis regresi linier berganda. Jumlah sampel penelitian sama dengan populasi penelitian sebanyak 30 orang guru. Penelitian ini dilaksanakan mulai bulan April 2020 ÔÇô Mei 2020. Hasil penelitian ini adalah variabel kompetensi memiliki pengaruh signifikan dan signifikan terhadap motivasi guru. Dengan adanya kompetensi yang baik sesuai dengan beban kerja, maka dapat menambah motivasi guru semakin baik dan meningkat. Variabel kompetensi, variabel pelatihan, dan variabel motivasi secara bersama-sama memilki pengaruh signifikan dan signifikan terhadap kinerja guru. Variabel kompetensi dan pelatihan secara bersama-sama memiliki pengaruh signifikan dan signifikan terhadap kinerja guru dengan motivasi sebagai variabel intervening. Variabel pelatihan memiliki pengaruh signifikan tetapi tidak signifikan terhadap motivasi guru.
Historie ženské emancipace jako téma muzejní prezentace: Příklad výstavy „Vlastním hlasem“
Authors: Gelnarová Jitka
Published: December 2022

The article focuses on the exhibition ‘In Her Own Voice’, which the National Museum organised in 2019 to mark the 100th anniversary of women’s suffrage in Czechoslovakia. The exhibition presented the history of the processes and paths of women’s emancipation in the Czech lands in the last two centuries and put contemporary issues related to women’s emancipation, gender equality and feminism into a historical context. The aim of this text is to present the concept of the exhibition and, through rich visual documentation, also its final form. It deals with the questions raised when preparing the concept of the exhibition and the dilemmas solved in the process. It highlights the limits of the possibilities of exhibiting this topic, which are linked to the nature of existing museum collections and the underrepresentation of certain themes and life experiences in them.
Libuše Bráfová a její sbírka oděvů z rodinné pozůstalosti
Authors: Marešová Vanda
Published: December 2022

Part of the collections of the Department of Old Czech History (The Historical Museum of the National Museum) is formed by objects preserved for future generations by Libuše Bráfová, daughter of the politician František Ladislav Rieger and the granddaughter of the historian František Palacký. Libuše Bráfová played a dominant role in preserving the family legacy and creating the ‘František Palacký and František Ladislav Rieger Memorial’ exhibition, where several hundred exhibits connected with this important Czech family are displayed. A large number of collection items and archival materials from the family estate still remain hidden in depositories. The presented paper focuses not only on this remarkable woman of many talents and activities, and her family background, but especially on the analysis of circumstances of the creation of the collection of personal and home textiles and clothing accessories originally belonging to individual members of the Palacký, Rieger and Bráf families.
TOXIC EFFECTS OF BENZODIAZEPINE RECEPTOR AGONISTS
Authors: Роман Анатольевич Калёкин, , Алла Андреевна Волкова, , Альбина Захаровна Павлова, , Алевтина Михайловна Орлова, , Андрей Леонидович Павлов,
Published: December 2022

Рассмотрена группа психотропных лекарственных средств - анксиолитиков при использовании в современной медицине с возможностью токсического воздействия на организм человека и вероятностью отравления ими. Описаны лекарственные препараты из агонистов бензодиазепиновых рецепторов применяемых в России как объекты химико-токсикологического и судебно-химического исследования.

A group of psychotropic drugs - anxiolytics when used in modern medicine with the possibility of toxic effects on the human body and the likelihood of poisoning by them is considered. Medicinal preparations from benzodiazepine receptor agonists used in Russia as objects of chemical-toxicological and forensic chemical research are described.
FLUXGATE MAGNETOMETERS. DEVELOPMENT ISSUES. PART 5: DIAGNOSTIC MAGNETOMETERS FOR MEDICINE
Authors: Владимир Валерьевич Любимов,
Published: December 2022

Даётся описание созданных в ИЗМИРАН простых и недорогих феррозондовых магнитометров - приборов для визуализации геомагнитных возмущений и магнитных бурь, которые предназначены для использования в медицинских учреждениях и исследовательских центрах. Приборы, позволяют проводить геомагнитные исследования и эффективно использоваться для исследований в медицине и магнитобиологии, а также предназначены для определения величины и местонахождения "вредных" электромагнитных возмущений искусственного происхождения.

A description of the simple and inexpensive fluxgate magnetometers created at IZMIRAN is given - devices for visualization of geomagnetic disturbances and magnetic storms, which are intended for use in medical institutions and research centers.The devices allow geomagnetic research and are effectively used for research in medicine and magnetobiology, and are designed to determine the magnitude and location of "harmful" electromagnetic perturbations of artificial origin.
SOUL-BODY DUALISM IN SPORTING ACTIVITIES
Authors: Галина Рубеновна Сарикек,
Published: December 2022

В статье рассматривается человек как средоточие материального и идеального начал, единство телесного и духовного. Особое внимание акцентируется на изучении культа тела и духа в Древней Греции. Подчеркивается, что спортивная деятельность в XXI веке выступает как возможность сохранения физического и поддержания психического здоровья личности.

The article deals with the man as a center of material and ideal principles, the unity of the corporeal and spiritual. Particular attention is paid to the study of the body cult and spirit in Ancient Greece. The article emphasizes that sports activities in the XXI century are an opportunity to maintain physical and mental health of the individual.
ASSISTANCE TO THE FRONT AND REAR OF THE ORTHODOX CLERGY OF THE UFA DIOCESE DURING THE FIRST WORLD WAR
Authors: Оксана Сергеевна Павлова,
Published: December 2022

В статье рассматривается деятельность уфимского епархиального духовенства по оказанию помощи фронту и тылу в годы Первой мировой войны. Автором сделаны выводы о том, что за время войны усилиями духовенства был организован сбор средств на нужды фронта, открывались госпитали, обеспечивались жильем и всем необходимым семьи солдат и беженцев. Уфимское духовенство проповеднической деятельностью внесло весомый вклад в воспитание патриотических чувств в обществе.

The article examines the activities of the Ufa diocesan clergy in providing assistance to the front and rear during the First World War. The author concludes that during the war, the efforts of the clergy organized fundraising for the needs of the front, hospitals were opened, and families of soldiers and refugees were provided with housing and everything necessary. The Ufa clergy made a significant contribution to the education of patriotic feelings in society through their preaching activities.
ANALYSIS OF INVESTMENTS AND TARIFFS IN TERMS OF RENEWABLE ENERGY SOURCES
Authors: Лаура Залимгериевна Налоева,
Published: December 2022

В статье приведён анализ глобальных инвестиций в развитие зелёной энергетики, определены особенности изменения ценовой политики источников энергии и выделены преимущества и ограничения для России. Представлены результаты возможных тарифов на электроэнергию при установке различных видов ВИЭ, в том числе гидроэнергетики, солнечных и ветряных станций.

The article provides an analysis of global investments in the development of green energy, identifies the features of changes in the pricing policy of energy sources, and highlights the advantages and limitations for Russia. The results of possible electricity tariffs for the installation of various types of renewable energy sources, including hydropower, solar and wind stations, are presented.
LLC "SARIA BIO-INDUSTRIES VOLGA «PRODUCTION LOGISTICS SYSTEM RESEARCH»
Authors: Альфия Левовна Файзханова, , Анастасия Александровна Посибеева,
Published: December 2022

В статье представлены результаты исследования эффективности функционирования системы производственной логистики ООО «САРИЯ Био-Индастрис Волга» и рекомендации по ее повышению.

The article presents the results of a study of the efficiency in LLC «SARIA Bio-Industries Volga» production logistics system and recommendations for its improvement.
HUMAN TRANSFORMATION IN THE GLOBAL COMMUNICATION SPACE
Authors: Лариса Викторовна Удалова,
Published: December 2022

В статье рассматриваются проблемы трансформации человека в глобальном коммуникационном пространстве, которое формируется современными информационными цифровыми технологиями. Особое внимание уделено тому, что коммуникация, как информационный фон, становится основой современной клиповой культуры, которая являясь носителем клипового сознания, влияет на механизмы смыслообразования человека, развивая определенные особенности восприятия информационного поля, формируя человека не мыслящего, а информированного, когда человек с мышления вербального переходит на восприятие визуальное.

The article deals with the problems of human transformation in the global communication space, which is formed by modern information digital technologies. Special attention is paid to the fact that communication, as an information background, becomes the basis of modern clip culture, which, being a carrier of clip consciousness, affects the mechanisms of human meaning formation, developing certain features of the perception of the information field, forming a person who is not thinking, but informed, when a person switches from verbal thinking to visual perception.
THE POSSIBILITIES OF USING CREATIVE TECHNOLOGIES IN EDUCATION
Authors: Эмилия Анатольевна Игнатьева,
Published: December 2022

Автор статьи раскрывает теоретические аспекты креативных технологий, анализирует основные характеристики и перспективы использования данного вида технологий в процессе обучения.

The author of the article reveals the theoretical aspects of creative technologies, analyzes the main characteristics and prospects of using this type of technology in the learning process.
OBTAINING ALIPHATIC PETROLEUM POLYMER RESINS BY VARIOUS METHODS
Authors: Илья Сергеевич Мельчаков, , Георгий Сергеевич Дмитриев, , Леонид Николаевич Занавескин, , Антон Львович Максимов,
Published: December 2022

Приведены результаты получения алифатических нефтеполимерных смол тремя способами. Определено, что термический и инициированный способы получения смолы в результате дают только жидкие смолы. Каталитический способ позволяет получить твердые смолы, по свойствам приближенным к коммерческим. Определен оптимальный катализатор и приведена блок схема получения алифатической смолы.

The results of obtaining aliphatic petroleum polymer resins by three methods are presented. It has been determined that the thermal and initiated methods of producing resin give only liquid resins. The catalytic method makes it possible to obtain solid resins with properties close to commercial ones. The optimal catalyst was determined and a block diagram for the production of an aliphatic resin was given.
A MOTIVATIONAL APPROACH TO THE TRAINING OF A HIGHER SCHOOL TEACHER IN THE CONCEPT OF LIFELONG EDUCATION
Authors: Полина Михайловна Алексеева,
Published: December 2022

В статье дается научное обоснование актуальности мотивации преподавателей высшей школы к повышению своей квалификации: описывается модель мотивации поведения через потребности, ожидания и результат.

The article is about a scientific substantiation of the relevance of the motivation of higher education teachers to improve their qualifications: a model of behavior motivation through needs, expectations and results.
MODERN FOREIGN LANGUAGE LESSON IN THE LIGHT OF GEF: PROBLEMS, APPROACHES AND SOLUTIONS
Authors: Зухра Ясуровна Кузяшева,
Published: December 2022

В данной статье исследованы актуальные вопросы, связанные с новыми подходами к организации урока по иностранному языку на примере французского языка, спроектированному на основе Федерального государственного образовательного стандарта основного общего образования. Автор делает вывод о том, что главной целью современного учителя иностранного языка выступает правильный выбор методов и форм организации учебной деятельности учащихся, которые оптимально соответствовали бы поставленной цели развития личности.

This article explores topical issues related to new approaches to organizing a lesson in a foreign language on the example of the French language, designed on the basis of the Federal State Educational Standard for Basic General Education. The author concludes that the main goal of a modern teacher of a foreign language is the correct choice of methods and forms of organization of educational activities of students that would optimally correspond to the goal of personality development.
РОЛЬ РОССИЙСКОЙ КУЛЬТУРЫ В ОБУЧЕНИИ КИТАЙСКОМУ ЯЗЫКУ КАК ИНОСТРАННОМУ ПРИ ПОДГОТОВКЕ СПЕЦИАЛИСТОВ В ОБЛАСТИ ФИЗИЧЕСКОЙ КУЛЬТУРЫ И СПОРТА
Authors: Алина Ивановна Шулина,
Published: December 2022

Изучение национальной культуры страны изучаемого языка в сравнении с культурой своей страны может оказать существенную помощь в преподавании языка. В докладе анализируется важность культурологических исследований в преподавании китайского языка как иностранного, сравниваются различия между китайской и русской культурами и даются рекомендации по обучению китайскому языку и культуре Китая.
WORLDVIEW UNIVERSALS AS BASIC VALUES OF CULTURE
Authors: Лариса Викторовна Удалова,
Published: December 2022

В статье рассматриваются мировоззренческие универсалии, как базовые ценности культуры, которые представляют ценностные приоритеты и создают целостный образ жизненного мира человека и на основании которых определяется его поведение и деятельность, в том числе и развитие сценариев будущего нашей цивилизации.

The article deals with worldview universals as the basic values of culture, which represent value priorities and create a holistic image of the human life world and on the basis of which his behavior and activities are determined, including the development of scenarios for the future of our civilization.
THE PHENOMENON OF "REELS" AS A CATALYST FOR SOCIO-CULTURAL DYNAMICS AT THE TICK-TOK SITE
Authors: Дмитрий Александрович Божедаров, , Яна Сергеевна Куляпина,
Published: December 2022

Авторский коллектив ведет целенаправленную исследовательскую работу по формированию современной теоретической базы такого феномена, как сетевая медиакоммуникация. Ее главное отличие от остальных коммуникативных процессов - отсутствие институциональных ограничений! Поэтому требует глубокого изучения, анализа и системополагающих выводов. «Reels» является одним из важнейших процессов, обеспечивающих ресурсностью для дальнейшего развития и усовершенствования платформы «Тик-Ток». В Китае он впервые вышел в свет в 2016 году и уже к 2018 году численность его аудитории достигла 800 миллионов человек в месяц [1, 127]. Это дает право полагать, что платформа «Тик-Ток» одна из самых популярных не только среди молодежной аудитории, но и старшего поколения. Имея в содержании контент, подготовленный коренными жителями российской глубинки, рассказы о быте простых людей, народной мудрости. Демонстрация фрагментов народных традиций указывает на то, что «Тик-Ток» содержит значительный культурологический информационный пласт, требующий исследования и теоретического осмысления. В «Тик-токе» содержится и молодежный контент раскрывающий многие проблемы, связанные с «трудным возрастом». Раскрываются проблемы взаимодействия поколений, просоциальные и асоциальные коммуникативные эффекты. Что дает право утверждать о том, что «Тик-Ток» - конструкция социальная, поэтому требует соответствующих подходов в изучении и дальнейшем использовании.

He author's team conducts purposeful research work on the formation of a modern theoretical basis for such a phenomenon as network media communication. Its main difference from other communication processes is the absence of institutional restrictions! Therefore, it requires in-depth study, analysis and system-setting conclusions. Reels is one of the most important processes that provide resources for the further development and improvement of the Tick-Tok platform. In China, it was first published in 2016 and by 2018 the number of its audience reached 800 million people per month [1, p.127]. This gives the right to believe that the Tiktok platform is one of the most popular not only among the youth audience, but also the older generation. Having in the content the content prepared by the indigenous inhabitants of the Russian hinterland, stories about the life of ordinary people, folk wisdom. The demonstration of fragments of folk traditions indicates that "Tik-Tok" is a social construction, therefore it requires appropriate approaches in the study and further use.
АНАЛИЗ СОСТОЯНИЯ И ПРОБЛЕМЫ СОВЕРШЕНСТВОВАНИЯ ПОЖАРНОЙ БЕЗОПАСНОСТИ НА ОБЪЕКТЕ
Authors: Владислав Саналович Чебулов, , Юлия Сергеевна Гермашева,
Published: December 2022

Обеспечение пожарной безопасности остается в списке самых серьезных проблем. При этом, несмотря на все меры, направленные на достижение этой цели, результаты пока оставляют желать лучшего.
ON THE PROSPECTS FOR THE DEVELOPMENT OF THE COAL INDUSTRY OF THE IRKUTSK REGION
Authors: Мария Александровна Балашова, , Ирина Всеволодовна Цвигун, , Александр Михайлович Балашов,
Published: December 2022

Практика последних лет вывела на повестку дня новые проблемы развития, как мировой, национальных экономик, так и их отдельных отраслей, в частности - угольной. В статье осуществляется попытка доказать, что, несмотря на все сложности работы современной угольной отрасли одного из регионов России - Иркутской области, закрывать ее нельзя. В качестве способа повышения уровня отраслевой конкурентоспособности предлагается вариант, подробно рассмотренный в работах М. Портера - организация работы по кластерному типу.

The practice of recent years has brought to the agenda new problems of development, both of the world, national economies, and of their individual industries, in particular, coal. The article attempts to prove that, despite all the difficulties of the modern coal industry in one of the regions of Russia - the Irkutsk region, it cannot be closed. As a way to increase the level of industry competitiveness, an option is proposed that is considered in detail in the works of M. Porter - the organization of work according to the cluster type.
INDUSTRIAL PRACTICE "RESEARCH WORK" AS A WAY OF FORMING ADDITIONAL PROFESSIONAL COMPETENCIES AMONG STUDENTS OF THE INSTITUTE OF PHARMACY
Authors: Ирина Константиновна Тухбатуллина, , Светлана Анатольевна Сидуллина, , Маргарита Альбертовна Гафурова,
Published: December 2022

Практика «Научно-исследовательская работа» позволяет студенту расширить список профессиональных компетенций. Все этапы освоения практических умений в период практики НИР в Институте фармации способствуют подготовке специалистов высокого профессионального уровня способных продолжить научно-исследовательскую работу в лабораториях фармацевтических предприятий.

The practice of "Research work" allows the student to expand the list of professional competencies. All stages of mastering practical skills during the period of R&D practice at the Institute of Pharmacy contribute to the training of specialists of a high professional level who are able to continue research work in laboratories of pharmaceutical enterprises.
УЧЕБНО-ПОЗНАВАТЕЛЬНАЯ ДЕЯТЕЛЬНОСТЬ КАК ОСНОВА ОБРАЗОВАНИЯ ШКОЛЬНИКОВ ПРИ ИЗУЧЕНИИ ГЕОГРАФИИ
Authors: Светлана Семеновна Великанова, , Оксана Геннадьевна Лисовская, , Наталья Сергеевна Галимзянова,
Published: December 2022

Целью данной статьи мы ставим теоретическое обоснование проблемы формирования учебно-познавательной деятельности школьников пи изучении географии на высоком уровне активности, анализ предпосылок и путей её решения. При этом мы исходим из понимания образования как системы учебно-познавательной деятельности школьников.

The purpose of this article is to theoretically substantiate the problem of the formation of educational and cognitive activity of schoolchildren in the study of geography at a high level of activity, the analysis of the prerequisites and ways to solve it. At the same time, we proceed from the understanding education as a system of educational and cognitive activity of schoolchildren.
THEORETICAL ASPECTS OF THE PROBLEM OF FORMATION OF TEACHERS' READINESS FOR COMMUNICATIVE INTERACTION
Authors: Ольга Владимировна Копанева,
Published: December 2022

В данной статье представлены результаты исследования по проблеме формирования готовности педагогов к коммуникативному взаимодействию в процессе межличностного взаимодействия.

This article presents the results of a study on the problem of formation of teachers' readiness for communicative interaction in the process of interpersonal interaction.
FORMATION OF TECHNOLOGY CHAINS FOR DIGITAL FACTORIES
Authors: Виктор Петрович Часовских, , Евгений Николаевич Стариков, , Елена Викторовна Кох,
Published: December 2022

Рассматриваются вопросы создания эффективных цифровых фабрик с точки зрения предприятий, занятых в различных отраслях промышленности. Определены основные компоненты и этапы формирования цифровой фабрики, а также сформулированы важнейшие показатели эффективности цепочки технологий, как набора компонентов цифровой фабрики с учетом отраслевой и технологической специфики предприятия.

The issues of creating effective digital factories are considered from the point of view of enterprises engaged in various industries. The main components and stages of the formation of a digital factory are determined, and the most important performance indicators of the technology chain are formulated as a set of components of a digital factory, taking into account the industry and technological specifics of the enterprise.