bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and Validation of a Prognostic Signature for Thyroid Cancer Based on Ferroptosis-Related Genes
Authors: Wang Yue , Yang Jing , Chen Shitu , Wang Weibin , Teng Lisong
Published: June 2022

Background: Thyroid cancer is the most common endocrine malignancy. Most PTC patients have a good prognosis; however, there are 5–20% of PTC patients with extra-thyroidal invasion, vascular invasion, or distant metastasis who have relatively poor prognoses. The aim of this study is to find new and feasible molecular pathological markers and therapeutic targets for early identification and appropriate management. Methods: The GEO and TCGA databases were used to gather gene expression data and clinical outcomes. Based on gene expression and clinical parameters, we developed a ferroptosis-related gene-based prognostic model and a nomogram. CCK-8, wound-healing, and transwell assays were conducted to explore the proliferation, migration, and invasion abilities of thyroid cancer cells. Results: We found 75 genes associated with ferroptosis that were differentially expressed between normal thyroid tissue and thyroid cancer tissues. The prognostic values of the 75 ferroptosis-related gene expressions were evaluated using the TCGA-THCA dataset, and five (AKR1C3, BID, FBXW7, GPX4, and MAP3K5) of them were of significance. Following that, we chose AKR1C3 as the subject for further investigation. By combining gene expression and clinical parameters, we developed a ferroptosis-related gene-based prognostic model with an area under the curve (AUC) of 0.816, and the nomogram also achieved good predictive efficacy for the three-year survival rate of thyroid cancer patients. Knocking down AKR1C3 enhances thyroid cancer cell proliferation, invasion, and migration abilities. Conclusions: A ferroptosis-related gene-based prognostic model was constructed that provided unique insights into THCA prognosis prediction. In addition, AKR1C3 was found to be a progression promoter in thyroid cancer cell lines.
New Genetic Variants in CYP2B6 and SLC6A Support the Role of Oxidative Stress in Familial Ménière’s Disease
Authors: Skarp Sini , Korvala Johanna , Kotimäki Jouko , Sorri Martti , Männikkö Minna , Hietikko Elina
Published: June 2022

The objective was to study the genetic etiology of Ménière’s disease (MD) using next-generation sequencing in three families with three cases of MD. Whole exome sequencing was used to identify rare genetic variants co-segregating with MD in Finnish families. In silico estimations and population databases were used to estimate the frequency and pathogenicity of the variants. Variants were validated and genotyped from additional family members using capillary sequencing. A geneMANIA analysis was conducted to investigate the functional pathways and protein interactions of candidate genes. Seven rare variants were identified to co-segregate with MD in the three families: one variant in the CYP2B6 gene in family I, one variant in GUSB and EPB42 in family II, and one variant in each of the SLC6A, ASPM, KNTC1, and OVCH1 genes in family III. Four of these genes were linked to the same co-expression network with previous familial MD candidate genes. Dysfunction of CYP2B6 and SLC6A could predispose to MD via the oxidative stress pathway. Identification of ASPM and KNTC1 as candidate genes for MD suggests dysregulation of mitotic spindle formation in familial MD. The genetic etiology of familial MD is heterogenic. Our findings suggest a role for genes acting on oxidative stress and mitotic spindle formation in MD but also highlight the genetic complexity of MD.
Automated Modeling of Road Networks for High-Definition Maps in OpenDRIVE Format Using Mobile Mapping Measurements
Authors: Chiang Kai-Wei , Pai Hao-Yu , Zeng Jhih-Cing , Tsai Meng-Lun , El-Sheimy Naser
Published: June 2022

With growing attention being devoted to autonomous vehicle (AV) safety, people have recently attached importance to high-definition (HD) maps. HD maps are not limited by environmental factors and can limit AVs driving in certain lanes. HD maps provide accurate auxiliary information on factors such as road geometry, traffic sign placement, and traffic topology. Nowadays, most HD maps are made from point clouds data, and this data contains accurate 3D position information. However, the production costs associated with HD maps are substantial. This article proposes an algorithm that reduces a great amount of time and human resource. The algorithm is divided into three phases, lane lines’ extraction from point clouds, modelling lane lines with attributes, and building OpenDRIVE file. The algorithm extracts lane lines resting on intensity value within the range of roads. Next, it models lane lines by cubic spline interpolation with the result of first phase, and build the OpenDRIVE file following the announcement of OpenDRIVE. The final result is compared with the verified HD map from the mapping company to analyze the accuracy. The root mean square (RMSE) obtained were 0.069 and 0.079 m for 2D and 3D maps, respectively.
In-Situ Evolution of Calcite Twinning during Uniaxial Compression of Carrara Marble at Room Temperature
Authors: Parlangeau Camille , Dimanov Alexandre , Hallais Simon
Published: June 2022

Calcite twinning is a dominant deformation mechanism at low temperatures. It is often used to reconstruct paleostresses: orientations of the principal stress axes, stress ratios and differential stress. Despite numerous studies, on single crystals and aggregates, questions remain about the initiation and evolution of the twinning. In particular, the existence of a critical value for the activation of twin planes is debated. In this study, Carrara marble samples were uniaxially deformed at low temperature. The experiments were monitored in situ in an SEM (Scanning Electron Microscope) and a deformation analysis was performed at regular intervals using image correlation. Image correlation analysis shows the link between the overconcentration of strains and the appearance of the first twinned planes. This is followed by a densification and a gradual thickening of the twin lamellae. Fracturing only appears in a third stage as a precursor to the collapse of the sample. The inversion, using the CSIT-2 technique, showed that the twinned planes are globally related to the applied macroscopic stress. The inversion allows one to retrieve the macroscopic stress tensor. Schmid factors were extracted from this analysis and correlated to the loading curves. For crystals of about 200 µm diameter, the threshold value is in between 6.75 and 8.25 MPa.
Anisotropy of Out-of-Phase Magnetic Susceptibility and Its Potential for Rock Fabric Studies: A Review
Authors: Hrouda František , Chadima Martin , Ježek Josef
Published: June 2022

In anisotropic materials such as minerals and rocks, the AC magnetic susceptibility is also anisotropic, and consists of two components, one in-phase with the applied field (ipMS) and the other out-of-phase (opMS). Correspondingly, anisotropies of these components, in-phase magnetic anisotropy (ipAMS) and out-of-phase anisotropy (opAMS), can be defined. In non-conductive dia- and paramagnetic materials, and in pure multi-domain magnetite, the opMS is effectively zero and only ipAMS can be measured. In some ferromagnetic minerals, such as pyrrhotite, hematite, titanomagnetite, or small magnetically viscous grains of magnetite, the opMS is clearly non-zero, and not only ipAMS but also opAMS can be determined. The opAMS can then be used as a tool for the direct determination of the magnetic sub-fabrics of the minerals with non-zero opMS. The precision in measurement of opMS decreases non-linearly with decreasing opMS/ipMS ratio, which may result in imprecise determination of the opAMS if the ratio is very low. It is highly recommended to inspect the results of the statistical tests of each specimen and to exclude the specimens with statistically insignificant opAMS from further processing. In rocks with a mono-mineral magnetic fraction represented by the mineral with non-zero opMS, the principal directions of the opAMS and ipAMS are virtually coaxial, while the degree of opAMS is higher than that of ipAMS. In some cases, the opAMS provides similar results to those provided by anisotropies of low-field-dependent susceptibility and frequency-dependent susceptibility. The advantage of the opAMS is in its simultaneous measurement with the ipAMS during one measuring process, whereas the other two methods require measurement in several fields or operating frequencies.
Effectiveness of a Worksite-Based Lifestyle Intervention on Employees’ Obesity Control and Prevention in China: A Group Randomized Experimental Study
Authors: Kong Jingxia , Chen Ying , Zheng Yingjing , Zhu Lin , Chen Boyan , Cheng Xiao , Song Mengna , Patrick Donald L. , Beresford Shirley A. A. , Wang Hongmei
Published: June 2022

Background: This study was to culturally adapt a lifestyle intervention for employees’ obesity control and prevention using a participatory process, and evaluate the effectiveness of the project at worksites. Methods: A group randomized experimental study included four worksites (two intervention, two control) in the Yangtze River Delta in China was conducted. A total of 388 participants (216 in the intervention worksites and 172 in the control worksites) were finally recruited from 955 employees at the four worksites (464 in the intervention worksites and 491 in the control worksites). The final evaluation was completed by two hundred and seventy-eight employees (159 in the intervention worksites and 119 in the control worksites, respectively). Data of demographic information, weight, BMI, waist circumference, hip circumference and weight-related behaviors including diary behaviors and physical activities were collected before and after a 12-month intervention and analyzed using descriptive statistics, t-test, chi-square test, linear mixed regression and logistic mixed regression. Results: Although the intervention worksites had a reduction in body mass index (23.21 to 22.95, p < 0.01), hip circumference (95.97 to 95.28, p = 0.03) and waist-to-height ratio (0.49 to 0.48, p = 0.01), the differential changes compared to those of the control group were not statistically significant. The frequency of sweet beverages (−1.81, 95%CI: −0.52, −3.11), frequency of vegetable intake (5.66, 95%CI: 1.59, 9.74), daily servings of vegetables (0.53, 95%CI: 0.24, 0.82), frequency of fruit intake (3.68, 95%CI: 1.25, 6.12), daily servings of fruit (0.26, 95%CI: 0.44, 0.92), daily servings of vegetables and fruit (0.79, 95%CI: 0.43, 1.16), daily steps (863.19, 95%CI: 161.42, 1564.97) and self-efficacy to change physical activity (OR = 1.91, 95%CI: 1.02,3.60) were more improved in the intervention group than were those measures in the control group. Conclusions: The worksite-based lifestyle intervention project for obesity control and prevention improved several employees’ dietary behaviors and physical activities at worksites in China in a short time. Long-term intervention with larger samples in more worksites should be further examined.
Velocity Variability and Performance in Backstroke in Elite and Good-Level Swimmers
Authors: Fernandes Aléxia , Goethel Márcio , Marinho Daniel A. , Mezêncio Bruno , Vilas-Boas João Paulo , Fernandes Ricardo Jorge
Published: June 2022

Backstroke swimming, a cyclic and continuous movement, displays a repeating structure due to the repeated action of the limb, presenting similar (but not identical) cycles. Some variability is generated by instabilities, but this may play a functional role in the human performance, allowing individual adaptations to constraints. The current study examined the role of velocity variability in backstroke performance, hypothesizing that this variable is associated with swimmers’ performance. Sixteen elite and fifteen good-level swimmers were video recorded in the sagittal plane when performing 25 m backstroke at maximal intensity in order to determine hip velocity and mean velocity, stroke rate, stroke length and indexes of coordination/synchronization. Lyapunov maximal exponent and sample entropy were also calculated for successive cycles. The elite swimmers’ performances were more unstable (0.1742 ± 0.1131 versus 0.0831 ± 0.0042, p < 0.001) and complex (0.9222 ± 0.4559 versus 0.3821 ± 0.3096, p < 0.001) than their good-level counterparts, but intracycle velocity variation did not differ (11.98 ± 3.47 versus 12.03 ± 3.16%, p > 0.05). Direct relationships were observed between mean velocity and stability (r = 0.40, p = 0.03), as well as with complexity (r = 0.53, p = 0.002), with intracycle velocity variation and complexity also being related (r = 0.38, p = 0.04). Backstroke performance is associated with velocity variability, with elite swimmers being able to control it through several adaptations, overcoming the high drag and inertia.
A Priori Dietary Patterns, Physical Activity Level, and Body Composition in Postmenopausal Women: A Cross-Sectional Study
Authors: Bendinelli Benedetta , Pastore Elisa , Fontana Miriam , Ermini Ilaria , Assedi Melania , Facchini Luigi , Querci Andrea , Caini Saverio , Masala Giovanna
Published: June 2022

Midlife weight gain and fat distribution changes increase the risk of age-related pathologies. We aimed to explore, in a series of 388 healthy postmenopausal women living in Tuscany, Central Italy, the relationship between three a priori dietary patterns, the level of physical activity (PA), and four body composition measures: body mass index (BMI), percent fat mass (%FM), percent muscle mass (%MM), and waist circumference (WC). Detailed information on lifestyle, including the amount of recreational and household PA, sitting time, and dietary habits were collected through detailed questionnaires, and adherence scores to Greek Modified Mediterranean Diet, Italian Mediterranean Diet (IMD), and Dietary Approaches to Stop Hypertension diet were calculated. The %FM and %MM were estimated via TANITA MC-780MA analyzer. WC and BMI were measured according to standard international protocols. Cross-sectional adjusted regression models showed that increasing adherence to IMD was inversely associated with BMI, %FM, and WC, and directly associated with %MM. Higher levels of recreational PA were associated with lower %FM, BMI, and WC and with higher %MM values. Higher levels of sitting time were associated with higher %FM, BMI, and WC, and lower %MM. Dietary habits and moderate PA confirm their central role in maintaining good health even in menopausal women.
Effects of Low-Load Blood Flow Restriction Training on Hemodynamic Responses and Vascular Function in Older Adults: A Meta-Analysis
Authors: Zhang Tianqi , Tian Guixian , Wang Xing
Published: June 2022

Background: The combination of low-load (LL) training with blood flow restriction (BFR) has recently been shown to trigger a series of hemodynamic responses and promote vascular function in various populations. To date, however, evidence is sparse as to how this training regimen influences hemodynamic response and vascular function in older adults. Objective: To systematically evaluate the effects of LL-BFR training on hemodynamic response and vascular function in older adults. Methods: A PRISMA-compliant systematic review and meta-analysis were conducted. The systematic literature research was performed in the following electronic databases from their inception to 30 February 2022: PubMed, Web of Science, Scopus, EBSCO host, the Cochrane Library and CNKI. Subsequently, a meta-analysis with inverse variance weighting was conducted. Results: A total of 1437 articles were screened, and 12 randomized controlled trials with a total 378 subjects were included in the meta-analysis. The meta-analysis results showed that LL-BFR training caused a significant acute increase in heart rate (WMD: 4.02, 95% CI: 0.93, 7.10, p < 0.05), systolic blood pressure (WMD: 5.05, 95% CI: 0.63, 9.48, p < 0.05) and diastolic blood pressure (WMD: 4.87, 95% CI: 1.37, 8.37, p < 0.01). The acute hemodynamic response induced by LL-BFR training is similar to that elicited by high-load (HL) training. Training volume, cuff pressure and width were identified as significant moderators in our subgroup and meta-regression analyses. After 30 min of training, resting systolic blood pressure significantly decreased (WMD: −6.595, 95% CI: −8.88, −3.31, p < 0.01) in the LL-BFR training group, but resting hemodynamic indexes exhibited no significant differences compared with common LL and HL training; long-term LL-BFR training resulted in significant improvements in flow-mediated vasodilation (FMD) (WMD: 1.30, 95% CI: 0.50, 2.10, p < 0.01), cardio ankle vascular index (CAVI) (WMD: 0.55, 95% CI: 0.11, 0.99, p < 0.05) and ankle brachial index (ABI) (WMD: 0.03, 95% CI: 0.00, 0.06, p < 0.05) in older adults. Conclusion: This systematic review and meta-analysis reveals that LL-BFR training will cause an acute hemodynamic response in older adults, which can return to normal levels 30 min after training, and systolic blood pressure significantly decreased. Furthermore, the beneficial effect of LL-BFR training on vascular function is to improve FMD, CAVI and ABI of older adults. However, due to the influence of the quality of the included studies and the sample size, more high-quality studies are needed to confirm such issues as BFR pressure and training risk.
How Official Social Media Affected the Infodemic among Adults during the First Wave of COVID-19 in China
Authors: Liu Huan , Chen Qiang , Evans Richard
Published: June 2022

The COVID-19 pandemic has demonstrated that social media can impact society both positively (e.g., keeping citizens connected and informed) and negatively (e.g., the deliberate spreading of misinformation). This study aims to examine the underlying mechanisms of the relationship between official social media accounts and the infodemic, experienced during the first wave of COVID-19 in China. A theoretical model is proposed to examine how official social media accounts affected the infodemic during this period. In total, 1398 questionnaire responses were collected via WeChat and Tencent QQ, two leading Chinese social media platforms. Data analysis was conducted using Partial Lease Squares Structural Equation Modeling (PLS-SEM), moderation effect analysis, and mediation effect analysis. Results indicate that the Information Quality (IQ) of Official social media accounts (β = −0.294, p < 0.001) has a significant negative effect on the infodemic. Mediation effect analysis revealed that both social support (β = −0.333, 95% Boot CI (−0.388, −0.280)) and information cascades (β = −0.189, 95% Boot CI (−0.227, −0.151)) mediate the relationship between IQ and the infodemic. Moderation effect analysis shows that private social media usage (F = 85.637, p < 0.001) positively moderates the relationship between IQ and the infodemic, while health literacy has a small negative moderation effect on the relationship between IQ and the infodemic. Our findings show that, in the context of Chinese media, official social media accounts act as a major source of information for influencing the infodemic through increasing social support and reducing information cascades for citizens.
Epidemiological Study of Risk Factors for Lung Cancer in KwaZulu-Natal, South Africa
Authors: Mbeje Noluthando P. , Ginindza Themba , Jafta Nkosana
Published: June 2022

The high incidence cancer rates are due to factors such as behavior, occupational exposures, genetics, environmental pollution and infections. The aim of this study was to identify risk factors associated with lung cancer among patients seen in the public health facilities in KwaZulu-Natal, South Africa. In this case-control study, 75 cases and 159 controls were interviewed using a structured close-ended questionnaire. Logistic regression showed a positive association between lung cancer and tobacco smoking (OR = 2.86, 95% CI: 1.21–6.77) and exposure to passive smoke (OR = 3.28, 95% CI: 1.48–7.30). When adjusted for other covariates, tobacco smoking and passive smoke were still positively associated with increased risk of lung cancer. Alcohol consumption (aORs ranging from 2.79 to 3.35) and history of lung disease (aORs ranging from 9.91 to 12.1) were statistically significantly associated with lung cancer. Our study suggests that tobacco smoke exposure is the major cause of lung cancer, and increased exposure to occupational and environmental carcinogenic substances, alcohol consumption and history of lung disease increase the risk of lung cancer. Based on our findings, policy development and planning of prevention strategies incorporating smoking legislations, occupational health and safety are essential in South Africa.
Supporting Adolescents with Mental Health Problems in Secondary Education: Feasibility of a Supported Education Intervention
Authors: Beukema Lindy , Hofstra Jacomijn , Reijneveld Sijmen A. , de Winter Andrea F. , Korevaar E. L.
Published: June 2022

Mental health problems in adolescence can have a profound influence on school functioning, educational attainment and thus future societal participation. Supported education (SEd) is a potentially useful method for educational professionals to help adolescents with mental health problems in secondary school improve their functioning by stimulating collaboration, ownership, and participation. In this study, we examined the feasibility of SEd in secondary education by examining its acceptability, implementation, and preliminary effectiveness. We performed a mixed-methods study using quantitative data (questionnaires) and qualitative data (interviews) from educational professionals (EP) and adolescents, aged 13–17, about their experiences with a SEd intervention. Regarding the acceptability of the intervention, three main themes emerged: (a) structure, (b) autonomy, and (c) applicability of the intervention. Themes regarding the implementation were: (a) lack of time, (b) personal attitude, (c) mastery, and (d) complexity of the school environment. The findings show that, for those that followed the intervention, SEd is a promising approach to support adolescents with mental health problems to improve their functioning and participation in school. Further research is needed on the effectiveness of the intervention.
Education for Sustainable Development and Meaningfulness: Evidence from the Questionnaire of Eudaimonic Well-Being from German Students
Authors: Klement Johannes , Terlau Wiltrud
Published: June 2022

Education for Sustainable Development (ESD, SDG 4) and human well-being (SDG 3) are among the central subjects of the Sustainable Development Goals (SDGs). In this article, based on the Questionnaire for Eudaimonic Well-Being (QEWB), we investigate to what extent (a) there is a connection between EWB and practical commitment to the SDGs and whether (b) there is a deficit in EWB among young people in general. We also want to use the article to draw attention to the need for further research on the links between human well-being and commitment for sustainable development. A total of 114 students between the ages of 18 and 34, who are either engaged in (extra)curricular activities of sustainable development (28 students) or not (86 students), completed the QEWB. The students were interviewed twice: once regarding their current and their aspired EWB. Our results show that students who are actively engaged in activities for sustainable development report a higher EWB than non-active students. Furthermore, we show that students generally report deficits in EWB and wish for an improvement in their well-being. This especially applies to aspects of EWB related to self-discovery and the sense of meaning in life. Our study suggests that a practice-oriented ESD in particular can have a positive effect on the quality of life of young students and can support them in working on deficits in EWB.
A Novel Approach on Deep Learning—Based Decision Support System Applying Multiple Output LSTM-Autoencoder: Focusing on Identifying Variations by PHSMs’ Effect over COVID-19 Pandemic
Authors: Jang Yong-Ju , Kim Min-Seung , Lee Chan-Ho , Choi Ji-Hye , Lee Jeong-Hee , Lee Sun-Hong , Sung Tae-Eung
Published: June 2022

Following the outbreak of the COVID-19 pandemic, the continued emergence of major variant viruses has caused enormous damage worldwide by generating social and economic ripple effects, and the importance of PHSMs (Public Health and Social Measures) is being highlighted to cope with this severe situation. Accordingly, there has also been an increase in research related to a decision support system based on simulation approaches used as a basis for PHSMs. However, previous studies showed limitations impeding utilization as a decision support system for policy establishment and implementation, such as the failure to reflect changes in the effectiveness of PHSMs and the restriction to short-term forecasts. Therefore, this study proposes an LSTM-Autoencoder-based decision support system for establishing and implementing PHSMs. To overcome the limitations of existing studies, the proposed decision support system used a methodology for predicting the number of daily confirmed cases over multiple periods based on multiple output strategies and a methodology for rapidly identifying varies in policy effects based on anomaly detection. It was confirmed that the proposed decision support system demonstrated excellent performance compared to models used for time series analysis such as statistical models and deep learning models. In addition, we endeavored to increase the usability of the proposed decision support system by suggesting a transfer learning-based methodology that can efficiently reflect variations in policy effects. Finally, the decision support system proposed in this study provides a methodology that provides multi-period forecasts, identifying variations in policy effects, and efficiently reflects the effects of variation policies. It was intended to provide reasonable and realistic information for the establishment and implementation of PHSMs and, through this, to yield information expected to be highly useful, which had not been provided in the decision support systems presented in previous studies.
A Comparison of Acute Effects of Climbing Therapy with Nordic Walking for Inpatient Adults with Mental Health Disorder: A Clinical Pilot Trial
Authors: Thaller Lisa , Frühauf Anika , Heimbeck Alexander , Voderholzer Ulrich , Kopp Martin
Published: June 2022

As climbing therapy is increasingly used for mental health disorders, the present study aimed to compare acute effects of a therapeutic climbing intervention (CT) on affective responses, anxiety, and self-efficacy with those of Nordic walking (NW) and a sedentary control condition (SC) in an inpatient setting with persons with depression, anxiety, or obsessive–compulsive disorders. A total of 21 inpatients (32 ± 12.2 years) participated in a clinical trial in all interventions using an experimental within-subject design. Anxiety and self-efficacy were assessed preintervention (t0) and postintervention (t2) using the State-Trait Anxiety Inventory and the General Self-Efficacy Scale, and affective responses were additionally evaluated during (t1) and 180 min after the intervention (t3) using the Feeling Scale, Felt Arousal Scale, and Positive and Negative Affect Schedule. Statistical evaluation was performed with a 3 × 2 or 3 × 4 repeated measures ANOVA. Significant interaction effects were found for affective responses regarding positive affect, affective valence, and perceived activation (p < 0.015) favoring CT over NW and SC. For anxiety, a significant interaction effect was found (F(2.40) = 6.603; p = 0.003; η2 = 0.248), and also perceived self-efficacy increased significantly (F(2.40) = 6.046; p = 0.005; η2 = 0.232). Single CT sessions may enhance affective responses and self-efficacy and reduce anxiety in inpatients with mental health disorders to a higher extent than NW. CT as part of an inpatient therapy program may help to improve key affective mechanisms and should be further studied in comparison with other exercise interventions with comparable intensity.
Occurrence and Fate of Triclosan and Triclocarban in Selected Wastewater Systems across Durban Metropolis, KwaZulu-Natal, South Africa
Authors: Bakare Babatunde Femi , Adeyinka Gbadebo Clement
Published: June 2022

Triclosan (TCS) and triclocarban (TCC) are antimicrobial agents that have been used in personal care and consumer products in the past decades. In this study, influent, effluent, and sludge samples collected in selected wastewater treatment plants across the Durban metropolis were qualitatively and quantitatively investigated. It was revealed that the concentration of TCS ranged from 1.906 to 73.462 µg/L, from 1.732 to 6.980 µg/L, and from 0.138 to 2.455 µg/kg in influent, effluent, and sludge samples, respectively. The concentrations of TCC were found to be between 0.320 and 45.261 µg/L, <LOQ–1.103 µg/L, and from 0.107 to 8.827 µg/kg in the influent, effluent, and sludge samples, respectively. Higher concentrations of TCS as compared with TCC were observed in the aqueous samples. However, the concentrations of TCC in the sludge samples were significantly higher than the level of TCS. More water solubility of TCS could be responsible for the observed trend in the influent and effluent samples, while the trend observed in the sludge could be due to the more hydrophobicity character of TCC. The results of this study indicated that substantial amounts of TCS and TCC are been removed during the treatment process which could be a major reason for the decline in the levels recorded in the effluent samples, therefore, reducing the amount of the TCS and TCC that would eventually end up in the surface rivers. Qualitative analyses of the samples indicated the presence of caffeine, tert-butylhydroquinone, chloroxylenol, phenol, 4-(1,1,3,3-tetramethyl butyl), and dimethyl-bisphenol A. Further investigative ecological risk assessment studies are crucial due to the potential threat the contaminants may pose to aquatic lives and humans.
Searching for the New Behavioral Model in Energy Transition Age: Analyzing the Forward and Reverse Causal Relationships between Belief, Attitude, and Behavior in Nuclear Policy across Countries
Authors: Kim Byoung Joon , Kim Seoyong , Kang Youngcheoul , Kim Sohee
Published: June 2022

This study aims to analyze the forward/reverse causal relationships between belief (risk perception), attitude (judgment), and behavior (acceptance). A traditional view stresses forward causal relationships between the three variables. However, recently, several studies have reported the possibility of reverse causal relationships between them. Based on survey data collected from 1027 Korean/Japanese participants, here we test not only the forward or reverse relationships between these three variables, but also how such causal relationships depend on the trust and country contexts (Korea and Japan in this study). The results showed that, first, not only a general forward causal relationship but also reverse causal relationship exists between belief, attitude, and behavior. Second, there exist the moderated mediation and mediated moderation effect of trust in government and media across two countries. Third, the effects of trust in government and media work significantly overall. However, the patterns of interaction effects differ between two countries. The level of trust in the government influenced the belief and attitude of citizens in Japan more than in Korea. However, the level of trust in the media showed opposite results.
Connecting Obstetric, Maternity, Pediatric and Preventive Child Health Care: A Comparative Prospective Study Protocol
Authors: Boertien Silke , Franx Arie , Jansen Danielle E. M. C. , Akkermans Henk , de Kroon Marlou L. A.
Published: June 2022

Collaboration between birth care and Preventive Child Health Care (PCHC) in the Netherlands is so far insufficient. The aim of the Connecting Obstetric; Maternity; Pediatric and PCHC (COMPLETE) study is to: (1) better understand the collaboration between birth care and PCHC and its underlying mechanisms (including barriers and facilitators); (2) investigate whether a new multidisciplinary strategy that is developed as part of the project will result in improved collaboration. To realize the first aim, a mixed-method study composed of a (focus group) interview study, a multiple case study and a survey study will be conducted. To realize the second aim, the new strategy will be piloted in two regions in an iterative process to evaluate and refine it, following the Participatory Action Research (PAR) approach. A prospective study will be conducted to compare outcomes related to child health, patient reported outcomes and experiences and quality of care between three different cohorts (i.e., those that were recruited before, during and after the implementation of the strategy). With our study we wish to contribute to a better understanding of collaboration in care and develop knowledge on how the integration of birth care and PCHC is envisioned by stakeholders, as well as how it can be translated into practice.
Inhibition of HIF-1α Attenuates Silica-Induced Pulmonary Fibrosis
Authors: Xu Xiao , Li Yiping , Niu Zhuoya , Xia Jiarui , Dai Kai , Wang Chen , Yao Wu , Guo Yonghua , Deng Xuedan , He Jing , Deng Meng , Si Huifang , Hao Changfu
Published: June 2022

Background: Excessive accumulation of extracellular matrix is a key feature of pulmonary fibrosis (PF), and myofibroblasts are the main producers of extracellular matrix. Fibroblasts are the major source of myofibroblasts, but the mechanisms of transdifferentiation are unclear. Methods: In vitro, transforming growth factor-β1 was used to induce NIH-3T3 cell transdifferentiation. DMOG was used to increase hypoxia-inducible factor-1α subunit (HIF-1α) expression. KC7F2 and siRNA decreased HIF-1α expression. In vivo, silica particles were used to induce PF in C57BL/6N mice, and KC7F2 was used to reduce HIF-1α expression in C57BL/6N mice. Western blot was used to detect the expression of collagen type 1 alpha 1(COL1A1), α-smooth muscle actin (α-SMA), SMAD family member (SAMD) 3, Phospho-SMAD3 (PSMAD3), and HIF-1α. PCR was used to detect the expression of COL1A1, α-SMA, and HIF-1α. Immunohistochemistry was used to detect the expression of COL1A1 and HIF-1α. Results: In vitro, compared to the control group, COL1A1, α-SMA, PSMAD3, and HIF-1α expression were elevated in the DMOG group, and COL1A1, α-SMA, PSMAD3, and HIF-1α expression were decreased in the KC7F2 group and siRNA group. Compared to the DMOG group, COL1A1, α-SMA, and PSMAD3 expression were decreased in the DMOG + SIS3 group. In vivo, compared to the saline group, COL1A1, α-SMA, PSMAD3, and HIF-1α expression were increased in the pulmonary tissue of C57BL/6N mice in the silica group. Compared to the silica group, COL1A1, α-SMA, PSMAD3, and HIF-1α expression and the degree of PF were decreased in the silica + KC7F2 group. Conclusion: Inhibition of HIF-1α reduced α-SMA, decreased COL1A1 expression, and attenuated the degree of PF in C57BL/6N mice. Therefore, HIF-1α may be a new target for the treatment of silica-induced PF.
Prevalence and Factors Associated with Musculoskeletal Disorders among Thai Burley Tobacco Farmers
Authors: Kongtawelert Amarin , Buchholz Bryan , Sujitrarath Dusit , Laohaudomchok Wisanti , Kongtip Pornpimol , Woskie Susan
Published: June 2022

This cross-sectional analysis study aimed to identify the prevalence and factors associated with musculoskeletal disorders (MSDs) among Thai Burley tobacco farmers. Subjects included 603 burley tobacco farmers from Sukhothai province. Farmers were interviewed twice, (during planting and harvesting seasons), with a questionnaire consisting of demographic and health characteristics, musculoskeletal symptoms, and ergonomic exposure questions. The subjects average age was 49.5 years, more were female (58.5%), most had only a primary education (74.3%), 38% were overweight or obese. Farmers had a significantly higher prevalence of MSDs in the lower back (37.1%), knee (28.7%), shoulder (22.9%), wrist (19.9%), and hip (8.3%) during the harvesting season than in the planting season (p < 0.05). Models found that factors influencing MSDs prevalence during planting included long work hours in seedling, tasks such as topping tobacco plants, and using machine tools, after controlling for age, gender, and body mass index (BMI). While in the harvesting season, models found tasks conducted as a group had lower MSDs prevalence than individual work when carrying fresh tobacco to the barn, piercing/threading and curing the leaves, baling the bundles, and transporting the finished goods. We recommended working in groups to reduce workload and MSDs, especially during harvesting, in burley tobacco farming.
Access to and Quality of Neighbourhood Public Open Space and Children’s Mental Health Outcomes: Evidence from Population Linked Data across Eight Australian Capital Cities
Authors: Alderton Amanda , O’Connor Meredith , Badland Hannah , Gunn Lucy , Boulangé Claire , Villanueva Karen
Published: June 2022

Neighbourhood-level interventions offer a promising opportunity to promote child mental health at a population level; however, neighbourhood effects are still regarded as a ‘black box’ and a better understanding of the specific design elements, such as public open space, is needed to inform actionable policy interventions. Methods: This study leveraged data from a population linked dataset (Australian Early Development Census—Built Environment) combining information from a national census of children’s developmental outcomes with individualised geospatial data. Associations between access to (within 400 m and 800 m from home), and quality of, public open space and child mental health outcomes across eight capital cities were estimated using multilevel logistic regression models, adjusting for demographic and contextual factors. Access was defined based on proximity of public open space to children’s home addresses, within distance thresholds (400 m, 800 m) measured along the road network. Effect modification was tested across maternal education groups. Results: Across the eight capital cities, inequities in access to child friendly public open spaces were observed across maternal education groups and neighbourhood disadvantage quintiles. Children with access to any type of public open space within 800 m of home had lower odds of demonstrating difficulties and higher odds of competence. Children with access to child friendly public open spaces within 800 m of home had the highest likelihood of demonstrating competence. Conclusion: Improving access to neighbourhood public open space appears to be a promising strategy for preventing mental health difficulties and promoting competence in early childhood. Action is needed to redress socio-spatial inequities in access to child friendly public open space.
Remanufacturing Strategy Choice of a Closed-Loop Supply Chain Network Considering Carbon Emission Trading, Green Innovation, and Green Consumers
Authors: Zhou Yan , Lin Xin-Tong , Fan Zhi-Ping , Wong Kar-Hung
Published: June 2022

Due to increasingly serious environmental pollution problems and governments’ strengthening of environmental impact supervision, manufacturing companies are seeking green production methods, implementing carbon trading systems, and promoting the trend towards green remanufacturing. Thus, this paper introduces green factors to the existing closed-loop supply chain network models and studies the impact of carbon trading, green innovation efforts, and green consumers on the choice between two remanufacturing strategies: an in-house remanufacturing strategy and an authorized remanufacturing strategy. The results concerning the choice of the remanufacturing strategy are as follows: from the perspective of obtaining more profits, when the carbon trading price is low, the companies choose the authorized remanufacturing strategy; when the carbon trading price is high, the companies choose to remanufacture by themselves. For all the green innovation efforts and the proportions of green consumers, when the recovery rate of the used product is low, the companies choose to remanufacture by themselves; when the recovery rate of the used product is high, the companies choose the authorized remanufacturing strategy.
Participation of Nursing Students in Evidence-Based Practice Projects: Results of Two Focus Groups
Authors: Baixinho Cristina Lavareda , Ferreira Óscar Ramos , Medeiros Marcelo , de Oliveira Ellen Synthia Fernandes
Published: June 2022

The development of true evidence-based practice requires that practitioners have the knowledge and skills to research, analyze, and use evidence. These skills must be acquired in pre-graduate training. The objective of the present study was to analyze the contributions of students’ participation in knowledge translation projects to clinical practice for evidence-based learning. This was a qualitative, descriptive, and exploratory study that used focus groups. Scripted interviews were administered. The design of the study included five phases and took place in the partnering institutions of the Safety Transition Project, involving fifteen participants. The study was authorized by the Research Ethics Committee. The data were analyzed following the steps encoding the categories, storage and recovery, and (3) interpretation and using computer software (WebQDA®, Ludomédia, Aveiro, Portugal). Four categories were identified: learning evidence; communicating science; evidence-based practice; and developing skills. The successful implementation of evidence-based practice education resulted in students who understand its importance and use it competently. Further research should explore the skills developed by nurses involved in similar projects and their contribution to an EBP culture.
Misophonia: A Systematic Review of Current and Future Trends in This Emerging Clinical Field
Authors: Ferrer-Torres Antonia , Giménez-Llort Lydia
Published: June 2022

Misophonia is a scarcely known disorder. This systematic review (1) offers a quantitative and qualitative analysis of the literature since 2001, (2) identifies the most relevant aspects but also controversies, (3) identifies the theoretical and methodological approaches, and (4) highlights the outstanding advances until May 2022 as well as aspects that remain unknown and deserve future research efforts. Misophonia is characterized by strong physiological, emotional, and behavioral reactions to auditory, visual, and/or kinesthetic stimuli of different nature regardless of their physical characteristics. These misophonic responses include anger, general discomfort, disgust, anxiety, and avoidance and escape behaviors, and decrease the quality of life of the people with the disorder and their relatives. There is no consensus on the diagnostic criteria yet. High comorbidity between misophonia and other psychiatric and auditory disorders is reported. Importantly, the confusion with other disorders contributes to its underdiagnosis. In recent years, assessment systems with good psychometric properties have increased considerably, as have treatment proposals. Although misophonia is not yet included in international classification systems, it is an emerging field of growing scientific and clinical interest.
Automated Machine Learning (AutoML)-Derived Preconception Predictive Risk Model to Guide Early Intervention for Gestational Diabetes Mellitus
Authors: Kumar Mukkesh , Ang Li Ting , Png Hang , Ng Maisie , Tan Karen , Loy See Ling , Tan Kok Hian , Chan Jerry Kok Yen , Godfrey Keith M. , Chan Shiao-yng , Chong Yap Seng , Eriksson Johan G. , Feng Mengling , Karnani Neerja
Published: June 2022

The increasing prevalence of gestational diabetes mellitus (GDM) is contributing to the rising global burden of type 2 diabetes (T2D) and intergenerational cycle of chronic metabolic disorders. Primary lifestyle interventions to manage GDM, including second trimester dietary and exercise guidance, have met with limited success due to late implementation, poor adherence and generic guidelines. In this study, we aimed to build a preconception-based GDM predictor to enable early intervention. We also assessed the associations of top predictors with GDM and adverse birth outcomes. Our evolutionary algorithm-based automated machine learning (AutoML) model was implemented with data from 222 Asian multi-ethnic women in a preconception cohort study, Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO). A stacked ensemble model with a gradient boosting classifier and linear support vector machine classifier (stochastic gradient descent training) was derived using genetic programming, achieving an excellent AUC of 0.93 based on four features (glycated hemoglobin A1c (HbA1c), mean arterial blood pressure, fasting insulin, triglycerides/HDL ratio). The results of multivariate logistic regression model showed that each 1 mmol/mol increase in preconception HbA1c was positively associated with increased risks of GDM (p = 0.001, odds ratio (95% CI) 1.34 (1.13–1.60)) and preterm birth (p = 0.011, odds ratio 1.63 (1.12–2.38)). Optimal control of preconception HbA1c may aid in preventing GDM and reducing the incidence of preterm birth. Our trained predictor has been deployed as a web application that can be easily employed in GDM intervention programs, prior to conception.
Exploring the Regional Coordination Relationship between Water Utilization and Urbanization Based on Decoupling Analysis: A Case Study of the Beijing–Tianjin–Hebei Region
Authors: Shen Ruihua , Yao Lei
Published: June 2022

Understanding the potential association between the urbanization process and regional water shortage/pollution is conducive to promoting the intensive utilization of local water resources. In this study, the water footprint model was used to estimate water utilization status in terms of both water quantity (virtual water footprint (VWF)) and water quality (grey water footprint (GWF)) in the Beijing–Tianjin–Hebei region (China) during 2004–2017. Their potential coordination relationship with the local urbanization process represented by the gross domestic product (GDP), population (POP), and built-up area (BA) was examined using the Tapio decoupling model. The results showed that from 2004 to 2017, (1) VWF in Beijing and Tianjin showed non-significant decreasing trends, with reductions of 1.08 × 109 and 1.56 × 109 m3, respectively, while that in Hebei showed a significant increasing trend, with an increase of 5.74 × 109 m3. This indicated a gradually increasing water demand in Hebei and decreasing demand in Beijing and Tianjin. In all three regions, the agricultural sector accounted for a relatively high proportion of VWF compared to other sectors. (2) GWF in Beijing, Tianjin, and Hebei all showed declining trends, with reductions of 2.19 × 1010, 2.32 × 1010, and 1.66 × 1011 m3, respectively, indicating considerable local water quality improvement. The domestic sector contributed as the main component of GWF in Beijing, while agriculture was the main contributor in Hebei. The major contributor in Tianjin transitioned from the domestic (before 2015) to the agricultural sector. (3) We found good coordination between VWF and GDP in all three regions, as their local economic development was no longer overly dependent on water consumption. However, the expansion of urban built-up area or population would bring about accelerated depletion of water resources. (4) GWF in the three provinces showed good coordination with GDP, POP, and BA in most years, implying that the development of urbanization no longer strongly caused the pollution of water resources. In sum, policymakers should focus on improving agricultural irrigation efficiency and residents’ awareness of water conservation, so as to gradually achieve sustainable water resource management in the BTH region.