bluuebunny/crossref_metadata_2025 huggingface dataset:
CHEMICALLY ACTIVE COMPOUNDS AND ANTI-MALARIAL EFFICACY OF (Syzygium cumini) STEM EXTRACTS ORIGINATED FROM IE SEUM GEOTHERMAL AREA
Authors: M. Munira  , N. Zakiah  , M. Nasir
Published: November 2024

In this study, we determined chemically active compounds extracted from Syzygium cumini stem using four different solvents, ethyl acetate, n-hexane, ethanol, and methanol. Gas Chromatography-Mass Spectrometry was used to investigate the chemical constituents in the targeted plant material and the in vitro antimalarial assay was evaluated through Giemsa staining microscopy utilizing the Plasmodium falciparum strain 3D7. The results indicate that the number of active compounds in the extract of ethyl acetate, n-hexane, ethanol, and methanol is 23, 7, 5, and 21 respectively, there are more compounds found in the ethyl acetate and methanol compared to ethanol and n-hexane. The antimalarial test confirmed that all four extracts were able to stop the growth of tested plasmodium but the ethyl acetate extract showed a remarkable ability to prevent the growth of plasmodium falciparum and completely inhibit it at the concentration of 100 µg/mL with the lowest IC50 of 11.08 µg/mL. The finding of this study could be useful for further development of natural product-based drugs for malaria disease treatment.
Social Networking Sites and Performance of Small and Medium Enterprises: Evidence from Oyo State, Nigeria
Authors: Ibrahim Kayode Muhammed , Akintayo Akintunde A. , Ayeni Emmanuel , Hassan Abidemi
Published: November 2024

The use of social media dramatically influences the effective and profitable performance
of businesses, especially SMEs. Nonetheless, more empirical studies are required to
enhance understanding the relationship between social media and SME success,
particularly in developing countries, Nigeria inclusive. The present research confirms
the suitability of social networking sites as an effective tool to enhance competitiveness
and performance among SMEs. Self-administered questionnaires were distributed
among 385 SME owners and managers in Oyo town, Oyo State. Descriptive data
were obtained with the help of a structured interview and purposeful sampling. The
exploratory study of data was done using descriptive analysis; another analysis was
the multinomial regression hypothesis analysis. The study findings showed that social
networking sites enhance SME performance more than any other factor, p < 0.01.
Based on these findings, the role of the social media tool is quite tactical in enhancing
SMEs' competitive advantage and productivity. The study shows how social
networking sites should be included in business strategies for growth and the
realization of sustainable business success in today's information age. These platforms
are recommended for business owners to enhance operations, reach more markets, and
eliminate vulnerability in the unstable business world.
Dynamics of Physical Parameters of Soils of the Meadow Range of the Stone Steppe
Authors: Cheverdin Yu. I. , Titova T. V. , Porotikov I. F.
Published: November 2024

A comparative analysis of the physical properties of meadow soils in agroforestry landscapes of the Central Chernozem region over a long period of time was carried out. The study was carried out on the soils of a seasonally waterlogged complex. According to the 2004 classification, these soils belong to hydrometamorphosed agrochernozems and humus-hydrometamorphic saline soils. The granulometric composition of the soils depended on the nature of soil moisture. In automorphic chernozems, a decrease in the proportion of the silty fraction of humus horizons was noted. Hydromorphic soils were characterized by an increased content of silt. Its role in carbonate horizons increased significantly. In the structural and aggregate state, an increase in the proportion of the lumpy fraction was noted in years with precipitation exceeding the long-term average. As part of the agronomically valuable aggregates, 5–10 mm aggregates were the dominant fraction. The share of small dusty aggregates accounted for an insignificant part. The use of chemical meliorants on meadow soils improved the structural condition of meadow soils. An increase in the structural coefficient was noted. All studied soil differences were characterized by high water resistance of structural separations.
Molecular Binding of Cycloxydim to Acetyl-CoA Carboxylase in Cultivated Soybeans and Weed Plants
Authors: Timkin P. D. , Ivaniy A. A. , Mikhaylova M. P. , Shtabnaya U. E. , Gretchenko A. E. , Serebrennikova Yu. O. , Penzin A. A.
Published: November 2024

Acetyl-CoA carboxylase (ACC) is one of the main enzymes that play a regulatory role in the biosynthesis of fatty acids in plants. Cyclodime is one of the herbicides that is an inhibitor of this enzyme. Some weedy cereal plants, such as common hedgehog (Echinochloa crus-galli L.) and annual bluegrass (Poa annua L.), are resistant to cycloxyme. Other types of grass weeds – blood-red dewdrop (Digitaria sanguinalis (L.) Scop.) and green bristle (Setaria viridis (L.) P. Beauv.), on the contrary, are susceptible to the herbicide. The molecular mechanisms underlying ACC resistance are poorly understood. The explanation of the mechanism of resistance probably lies in the structure of ACC in different species. The use of bioinformatics methods will help to understand the mechanisms of adaptation based on the molecular properties of the enzyme, which will contribute to the creation of new herbicides. The purpose of this work was to study the specifics of the binding of cycloxydime to the ACC enzyme for each of these weed species, including soy (Glycine max (L.) Merr.). For weeds E. crus-galli and P. annua revealed from 6 to 7 possible complexes with different ligand positions relative to the receptor, which could potentially explain the mechanism of resistance. At the same time, a low binding energy was determined for the cycloxydime complex with G. max (up to –7.31 kcal/mol), which demonstrates the presence of other resistance mechanisms in the culture.
Formation of local structural order in the aluminum melt before crystallization
Authors: Vorontsov V. B. , Pershin V. К.
Published: November 2024

The results of an experimental study of acoustic emission spectra (AE) in the frequency range of 20–200 kHz, which occur when the temperature of the aluminum melt decreases from 860 to 660°C. The paper discusses the relationship between acoustic signals and the processes of structural transformations in the melt as the temperature.
Potentiostatic electrolysis of fluoride melts with zirconium oxide additives
Authors: Filatov А. А.
Published: November 2024

Currently, the demand for zirconium-based alloys and materials is growing significantly due to their high thermal and corrosion resistance combined with mechanical strength. Existing technologies for producing zirconium and its alloys are complicated by the high temperature of the process, or labor intensity and multi-stage nature, which significantly increases the cost of the target material up to the loss of profitability of the process. Electrochemical synthesis of zirconium and its alloys in fluoride-based melts, using zirconium oxides as the main metal-containing consumable component, seems more profitable. In this work, a series of electrolysis tests were carried out to deposit Al-Zr alloy at a potential of 1.6 V on graphite and molybdenum cathodes. According to the previously obtained results, in the presence of ZrO2 in the KF-AlF3-Al2O3 melt, a plateau and a discharge peak of electroactive ions appear on the cathode branch of the voltammograms at potentials of -1.4 and -1.7 V, ZrI and ZrII, respectively. Similar responses appear on tungsten at potentials of -1.3 and -1.6 V, respectively, and in the potential region of -1.9 V there is a clear peak (Al) of electroreduction of aluminum ions. As a result of electrolysis, it was found that the graphite anode was consumed, and a fairly well-bonded deposit was formed on the cathode. Part of the cathode deposit was mechanically separated from the cathode for analysis of its chemical and phase composition. Based on the results of X-ray phase analysis, it was found that the cathode deposit mainly consists of Al3Zr and aluminum compounds with molybdenum impurities, with the composition Al12Mo, which is consistent with known ideas about the formation of intermetallic compounds during the interaction of aluminum with other metals. Electrolysis of the melt on the graphite cathode was carried out under similar conditions. Based on a microphotograph of the cathode cross section, it was found that during electrolysis, a layer of deposit containing both zirconium and aluminum was formed at the electrode-electrolyte phase boundary.
Electrodeposition of ordered silicon fibers from the KI–KF–KCl–K2SiF6 melt for lithium-ion power sources
Authors: Leonova А. М. , Leonova N. М. , Minchenko L. М. , Suzdaltsev А. V.
Published: November 2024

The possibility of using silicon-based anodes in lithium-ion power sources is actively investigated due to the increased lithium capacitance of silicon. This work reports the preparation of submicron silicon fibers on glassy carbon in KI–KF–KCl–K2SiF6 melt at 720°C. For this purpose, the parameters of silicon electrodeposition in the form of fibers were determined by cyclic voltammetry, experimental batches of ordered silicon fibers with an average diameter from 0.1 to 0.3 μm were obtained under galvanostatic electrolysis conditions, and using the obtained silicon fibers, anode half-cells of lithium-ion current sources were fabricated and their electrochemical behavior and behavior under multiple lithiation and delithiation were studied. By means of voltammetric studies, it is observed that charging and discharging of the anode based on the obtained silicon fibers occurs at potentials from 0.2 to 0.05 V and from 0.2 to 0.5 V, respectively. Cycling of electrodeposited silicon fibers in anode half-cells of lithium-ion power source was carried out. Depending on the charge current, the discharge capacity ranged from 200 to 500 mAh/g at Coulomb efficiency of 98–100 %. Also, multiple cycling of the sample of lithium-ion power source with a lithium counter electrode was performed. In the course of 800 cycling with current 0.5C, the discharge capacity of the sample decreased from 165 to 65 mAh/g. Scanning electron microscopy shows the volumetric expansion of the of silicon fibers during cycling.
Complex for Thomson Scattering Diagnostics on the TRT Tokamak
Authors: Mukhin E. E. , Tolstyakov S. Yu. , Kurskiev G. S. , Zhiltsov N. S. , Ermakov N. V. , Tkachenko E. E. , Koval A. N. , Solovey V. A. , Aleksandrov S. A. , Nikolaev A. V. , Antropov D. A. , Bondar A. V. , Kedrov I. V. , Marchenko T. A. , Kornev A. F. , Makarov A. M. , Bogachev D. L. , Samsonov D. S. , Guk E. G. , Klimov V. N. , Smirnova E. P. , Sotnikov A. V. , Razdobarin A. G. , Bazhenov A. N. , Bocharov I. V. , Bocharnikov V. A. , Bukreev I. M. , Dmitriev A. M. , Elets D. I. , Tereshchenko I. B. , Varshavchik L. A. , Chernakov A. P. , Pankrat’ev P. A. , Marchii G. V. , Minbaev M. , Nikolaenko K. O. , Kungurtsev N. A. , Sakharov N. V. , Petrov Y. V. , Mokeev A. N.
Published: November 2024

A diagnostic system for Thomson scattering of the central, edge and divertor plasma regions of a tokamak with reactor technologies is discussed. The rationale and choice of technical solutions are given, the composition of the Thomson scattering diagnostic complex is discussed, as well as an estimate of the accuracy of measuring the electron temperature and plasma density in the central edge and divertor regions of the TRT tokamak. Particular attention is paid to ensuring the functionality of the proposed diagnostics in the reactor mode of the tokamak operation and the results of testing diagnostic equipment in experiments on the Globus-M2 tokamak.
Study of the Method of Photon Neutralization of Powerful Beams of Negative Ions at the Budker Institute of Nuclear Physics
Authors: Popov S. S. , Atlukhanov M. G. , Burdakov A. V. , Ivanov A. A. , Kurkuchekov V. V. , Sanin A. L. , Skovorodin D. I. , Trunev Y. A. , Shikhovtsev I. V.
Published: November 2024

A short review of the studies carried out at the Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences (BINP SB RAS) on the photon neutralization of the beams of negative ions is presented. The principal distinctive feature of the presented approach consists in the nonresonant accumulation of photons in a limited space. Their confinement is based on the adiabatic motion of photons in a system of concave mirrors, which is insensitive to the quality of the injected radiation. An analysis is carried out of the possibility of using the neutralizer based on such a nonresonant photon trap in large-scale installations such as ITER and TRT, and a future experiment is described on the photon neutralization using a beam of negative hydrogen ions with energy up to 130 keV and a current of about 10 mA.
Possibilities of Using Active Neutral Particle Diagnostics at the TRT Facility
Authors: Afanasyev V. I. , Melnik A. D. , Mironov M. I. , Navolotsky A. S. , Nesenevich V. G. , Petrov M. P. , Petrov S. Ya. , Chernyshev F. V. , Shmitov R. Y.
Published: November 2024

The possibilities of using active neutral particle diagnostics for measuring local ion temperatures and isotopic ratio of deuterium-tritium plasma at the tokamak with reactor technologies are considered. Options for positioning the neutral particle analyzer relative to the diagnostic injector are presented. The fluxes of deuterium and tritium atoms escaping out of plasma were simulated in a wide range of plasma densities and temperatures. It is shown that the neutral particle analyzer active diagnostics will make it possible to measure the plasma parameters mentioned with the spatial and time resolutions of ~14 cm and ~0.01—0.1 s, respectively.
Nanocomposite of Graphene-Phosphorene Structures with Cobalt Phosphide as Effective Electrocatalyst for Hydrogen Evolution Reaction in Acidic Medium
Authors: Kochergin V. K. , Manzhos R. A. , Kabachkov E. N. , Khodos I. I. , Krivenko A. G.
Published: November 2024

Materials containing cobalt phosphide nanoparticles are among the most promising electrocatalysts for the hydrogen evolution reaction in terms of the ratio of activity, cost and durability. This work presents a simple and effective approach for obtaining a nanocomposite of graphene-phosphorene structures decorated with CoP nanoparticles 2–5 nm in size. The nanocomposite was obtained by electrochemical exfoliation of black phosphorus followed by solvothermal synthesis carried out in the presence of few-layer graphene structures doped with nitrogen atoms in a solution containing Co2+ ions. It has been established that the obtained electrocatalyst demonstrates high activity and stability towards hydrogen evolution reaction in an acidic medium. In order to achieve a current density of 10 mA cm–2, an overpotential of ~220 mV is required, while the Tafel slope is ~63 mV dec–1. It has been suggested that this result is due to both the synergistic effect of the interaction between graphene and phosphorene structures and the electrocatalytic activity of nanosized CoP particles present at the edges of phosphorene structures.
Electrodeposition of Photosensitive Layers Based on Conducting Polymers and Zinc Phthalocyaninate, Their Structure and Photoelectrical Properties
Authors: Gribkova O. L. , Kabanova V. A. , Kormshchikov I. D. , Tameev A. R. , Nekrasov A. A.
Published: November 2024

Photosensitive hybrid layers were obtained by electrochemical polymerization of pyrrole and 3,4-ethylenedioxythiophene (EDOT) in the presence of water-soluble sodium salt of zinc octa(3ʹ,5ʹ-dicarboxyphenoxy)phthalocyaninate (ZnPc) containing 16 ionogenic carboxylate groups. It was found that the process of electrodeposition of hybrid layers most effectively occurs in galvanostatic and potentiostatic modes on the sublayer of the PEDOT-polyacid complex. The electronic and chemical structure and morphology of hybrid layers of polypyrrole (PPy) obtained in the presence of ZnPc were studied. Possible reasons are considered that the measured values of photosensitivity and external quantum yield of charge carrier generation in PPy-ZnPc are several times higher than in PEDOT-ZnPc.
Fungal Hydrophobins: Biosynthesis, Properties, Possibilities of Application in Biotechnology (Review)
Authors: Lopatukhin E. V. , Ihalainen Yu. A. , Markelova N. N. , Kuvarina A. E. , Sadykova V. S.
Published: November 2024

The review summarizes current information about hydrophobins – low molecular weight proteins synthesized by filamentous fungi and which are one of the strongest cellular biosurfactants. The mechanism of biosynthesis of hydrophobins, the chemical structures and spectrum of its natural and synthetic isoforms, biological activity and role in the regulation of vital processes of producers are presented. The potential for using hydrophobins in biotechnology has been demonstrated.
Recombinant Chymotrypsin-Like Peptidase from Tenebrio molitor with a Non-Canonical Substrate-Binding Site
Authors: Tereshchenkova V. F. , Zhiganov N. I. , Gubaeva A. S. , Akentyev F. I. , Dunaevsky Ya. E. , Kozlov D. G. , Belozersky M. A. , Elpidina E. N.
Published: November 2024

We characterized an alkaline chymotrypsin-like serine peptidase from the yellow mealworm Tenebrio molitor with a non-canonical substrate-binding subsite for its possible application as a component (an additive) in various biological products. The enzyme was obtained as a recombinant preparation. Purification was carried out using affinity chromatography on Ni2+-NTA agarose. The specificity constants (kcat/KM) for the chymotrypsin substrates, Glp-AAF-pNA, Suc-AAPF-pNA, and Ac-Y-pNA were 7, 4.2 and 0.9 (µM∙min)–1, respectively. Optimum of the proteolytic activity was observed at pH 9.0. The enzyme was stable at the alkaline pH range, and in the presence of BSA also in the acidic region. Peptidase was inhibited by synthetic inhibitors such as PMSF, TPCK, chymostatin, while EDTA, E-64, and pepstatin had no effect on the enzyme activity. The purified enzyme showed high stability over time in the presence of BSA. The short life cycle of the insect and the production of a large number of peptidases in the midgut with high catalytic activity and stability can make T. molitor an excellent alternative source of industrially important enzymes for application as components (additives) in various biological products (e. g., stain removers, detergents, etc.).
The Diatom Nanofrustulum shiloi as a Promising Species in Modern Biotechnology
Authors: Blaginina A. A. , Zheleznova S. N. , Miroshnichenko E. S. , Gevorgiz R. G. , Ryabushko L. I.
Published: November 2024

The article presents the results of studies of intensive culture of a new species of bentoplanktonic diatom N. shiloi (Lee, Reimer et McEnery) Round, Hallsteinsen et Paasche 1999 for the Black Sea. The features of the process of isolating the species into an algologically pure culture, as well as the morphological and taxonomic characteristics of the strain in light and electron scanning microscopes are described in detail. The biochemical and production characteristics of the strain were studied, as well as the ability to accumulate fucoxanthin (Fx) and polyunsaturated fatty acids (PUFA) in laboratory conditions. In the exponential growth phase, the specific culture growth rate was µ=0.8 1/day, and the maximum productivity P = 0.46 g dry weight /(L day). The accumulation of PUFAs in the biomass of N. shiloi reached 67.39 mg/g dry weight of algae. The Fx concentration in the biomass at the beginning of the stationary growth phase was 10 mg/g dry weight. The fairly high rate of Fx biosynthesis in microalgae cells, as well as the composition of fatty acids of the Black Sea strain, make it possible to classify N. shiloi as a promising object in biotechnology.
Composite Solid Electrolytes
Authors: Matveev E. S.
Published: November 2024

The review describes composite electrolytes based on classical salt matrix phases, and also shows the possibilities of creating composites using simple or complex oxide matrices, where simple substances, salts, simple and complex oxides are used as heterogeneous dopant. The magnitude of the composite effect of electrical conductivity is discussed from the point of view of various theories of its quantitative description. The reasons for the occurrence of the composite effect are summarized. The effect of increasing ionic conductivity is due to the disorder of the surface layer in the intergranular space, amorphization or spreading of the matrix phase or the phase of heterogeneous dopant over the surface of the other phase due to the difference in surface energy, as well as the possibility of joint manifestation of these effects when using complex oxide eutectic composites with treatment above the temperature of the eutectic system.
Characteristics of Aliphitic and Aromatic Ion-Exchange Membranes after Electrodialysis Tartrate Stabilization of Wine Materials
Authors: Pasechnaya E. L. , Ponomar M. A. , Klevtsova A. V. , Korshunova A. V. , Sarapulova V. V. , Pismenskaya N. D.
Published: November 2024

Color indication of anthocyanins, FTIR spectroscopy, measurement of surface contact angle values, determination of specific electrical conductivity, as well as voltammetry and parallel measurement of pH of desalted solutions were used to analyze the fouling characteristics of aliphatic (CJMA-3, CJMC-3) and aromatic (AMX-Sb, CMX-Sb) ion-exchange membranes used in electrodialysis tartrate stabilization of wine material. It has been shown that polyphenols form complexes with metal ions on the surface and in the subsurface layers of cation-exchange membranes, which do not interfere with the transfer of cations. Foulants affect the magnitude of limiting currents and enhance water splitting at the surface of all studied membranes, and also reduce the electrical conductivity of anion-exchange membranes. The use of a pulsed electric field instead of a continuous direct electric current, traditional for electrodialysis, weakens the negative impact of foulants on membranes’ electrical conductivity. These data can be useful for selecting membranes and current modes when carrying out electrodialysis tartrate stabilization of wine materials.
HIERARCHICAL SPECIFICATION OF GRAPHICAL USER INTERFACES USING A	GRAPH GRAMMAR APPROACH
Authors: Goedicke M. , Tröpfner P. , Enders-Sucrow B.
Published: November 2024

In this contribution we consider a rule based visual language for the specification of graphical user interfaces (GUIs). Our approach uses a graph rewrite approach in such a way that the state of a GUI is represented as a complex visual graph. An action is represented by a visual rewrite rule applicable to a graph of this form. Since the GUI features are represented as little pictures like windows, listboxes etc. it is necessary to define these problem oriented representa-tions by a more abstract mathematical formalism. We use graphs to represent the semantics of the problem oriented representation. Complex actions and events are modelled by rewrite steps on these graphs. Usually complex GUIs are described by a hierarchy of interaction objects. Such a hierarchy is adequately expressed as a hierarchy of graph layers. We present how the various descriptions of picture graphs and graphs as well as visual rules and graph rewrite rules, respectively, are integrated by a method using special mappings.
VIRTUAL TRANSPORT ENTERPRISE INTEGRATION
Authors: Chalmeta Ricarda
Published: November 2024

A virtual transport enterprise (VTE) is a temporary alliance of independent transport enterprises that come together to share resources, skills, and costs, supported by Information and Communication Technologies, in order to better attend market opportunities. To design an efficient and flexible VTE that presents the semblance of a single enterprise to the customers, is a very complex task. There are an extensive set of approaches to help in the co-ordination of the different objectives during of the design and execution of a single enterprise. However, they do not provide the specialized tools for the integration of VTEs. This paper shows a Reference Architecture that is being developing focused on the virtual intermodal transport enterprise. This Architecture guide (1) in the design of high quality business process, with an information flow connecting the services in the transport chain and (2) in the development of an integrated system of management. The architecture is composed of a methodology, a reference model, a performance measurement system, an information and communication infrastructure and a set of computer engineering tools.
EVOLUTIONARY DEVELOPMENT OF BUSINESS PROCESS CENTERED	ARCHITECTURES USING COMPONENT TECHNOLOGIES
Authors: Sünbül Asuman , Weber Herbert , Padberg Julia
Published: November 2024

The process centered paradigm changed the way of todays business organizations. Both the organizational structure and the IT-infrastructure are effected by this paradigm shift. For companies, competitiveness means meeting the continuously changing business requirements, concerning business environments and workflows. Structural modifications caused by continuously changing business processes, and ad-hoc-modifications triggered by spontaneous events provoke adaptability problems: in all these cases, the software system must be adapted accordingly in order to be consistent with the modified business process. Because of the fact, that that adaptation is costly, time consuming, alternatives paradigms have to be considered. In this paper, we therefore propose to use an evolutionary strategy for the development of business process based applications. In our approach, each modification request caused by a change of the business process implies an evolution step in the architecture of the workflow based applications. In this paper we present EVA, a strategy for forming such evolvable architectures for communication and information infrastructure referred to as EVA. ¹ The initial models for EVA are business process models as a basis for modeling system architectures. We use Petri nets for representing the dynamic characteristics of the business processes. The evolution concept on the software architectural level is covered by the application of component strategies. In this paper we will present a concept for the design of evolution in workflow components (Padberg et al., 1999) and explain the composition of these components. ¹ This paper describes the conceptual foundations and design aspects of EVA. In contrast, (Weber et al., 2000) focuses on the formal foundations of EVA.
AUTOMATIC SYNTHESIS OF BEHAVIORAL OBJECT SPECIFICATIONS FROM	SCENARIOS
Authors: Khriss Ismaïl , Elkoutbi Mohammed , Keller Rudolf K.
Published: November 2024

The use of scenarios has become a popular technique for requirements elicitation and specification building. Since scenarios capture only partial descriptions of system behavior, an approach for scenario composition and integration is needed to produce more complete specifications. The Unified Modeling Language (UML), which has become a standard notation for object-oriented modeling, provides a suitable framework for scenario acquisition using Use Case diagrams and Collaboration diagrams and for behavioral specification using Statechart diagrams; yet it does not propose any specific modeling process, let alone a process for transforming scenarios into behavioral specifications. In this paper, we suggest a four-step process for synthesizing behavioral specifications from scenarios. It automatically generates from a given set of Collaboration diagrams the Statechart diagrams of all the objects involved. An automatic analysis of specifications in respect to consistency and completeness is also provided. Our approach is incremental and is fully compliant with the UML. Furthermore, it provides an elegant solution to the problem of scenario interleaving. The underlying algorithms have been implemented and validated with several examples, and they are fit for integration into CASE tools supporting the UML.
EXPERIENCES IN 3-DIMENSIONAL VISUALIZATION OF JAVA CLASS	RELATIONS
Authors: Alfert Klaus , Engelen Frank
Published: November 2024

Java software provides a vast amount of information about class and interface relations. Inheritance- or uses-relations of large software systems lay great demands on being able to overview the scene. Class browsers may help to master the information, although visualization is usually limited to two dimensions. We analyze the benefits of 3D presentation and discuss experiences with our visualization tool J3Browser. The tool realizes these benefits and some selected visualization techniques within the Java context. This paper leads to a step towards a CAD-like design of Java software in 3D space.
A VALUE BASED BUSINESS PROCESS MANAGEMENT NETWORK MODEL
Authors: Sobrinho Fuad Gattaz , Gattaz Cristiane Chaves , Pacheco Oscar Ivan Palma
Published: November 2024

As in the foundation and principles for complex process science and engineering, a major problem is the lack of formal specification language to treat the dynamics of modeling complex processes with its simulations, emulations and enactments. This paper defines a formal specification language which allows integrating the complex thinking with software engineering principles for guiding the characterization of minimum requirements to design technology within living complex processes. There is a lack of research in the literature referring to the model process structural complexity. Such a model complex process can be directed toward acquiring good maintainability attributes according to the principles of complex process science and engineering. In this work a Value Based Business Process Management Network Model (VBPMN) is developed to acquire directly from the target complex process codes the knowledge hidden among and within composite and elementary complex processes.
Determining the Resistance of a Mediaeval Ship by Numerical Analysis: Case Study of the Ship Nin 1
Authors: Sviličić Šimun , Rudan Smiljko , Radić Rossi Irena , Lucchini Alice
Published: November 2024

In the late 60’s of the last century, the well-preserved remains of two medieval ships were discovered in Nin (Croatia), in the inner Nin lagoon. In the next few decades, the remains were raised from the sea, conserved, partly reconstructed, and studied by nautical archaeologists, who analysed the ship to estimate its original dimensions and topology, resulting in three different sets of hull lines with slight variations in width, length, and shape. Nin 1 lacks a traditional keel and instead features a stem, providing structural integrity to the bow and making the ship better suited for shallow waters which makes it unconventional when hydrodynamic calculations are considered, as there are no empirical methods for calculating such a ship’s resistance in a fast and reliable way. In this research, CFD is employed to precisely evaluate all three versions of Nin 1, aiming to identify the most efficient form among them, which is likely to be the original design. Three ship models are generated, based on each set of lines, and subjected to the same examined scenarios, i.e., sailing through calm water in the velocity range between 0.5 and 7 kn. The turbulence phenomenon is also analysed by applying the adequate turbulence model while respecting the appropriate mesh size. By applying the CFD method, each component of resistance is determined so that the effects of different hull forms and appendage dimensions are visible separately.
A Methodology for Predicting Vertical Motions in Ship Concept Design
Authors: Utzeri Samuele , Braidotti Luca , Norcia Nicola , Marino’ Alberto
Published: November 2024

The seakeeping performance of a ship is one of the primary characteristics to be considered during the design phase to determine the ship’s response in irregular sea conditions. The ship’s main geometric parameters must be selected in the very early stages of design as they influence the seakeeping performance, ensuring compliance with the operational conditions specified by the shipowner. In particular, for cruise ships, it is essential to evaluate the vertical motions to provide comfort for the passengers. It is intended to propose a statistical methodology for calculating the vertical motions of a cruise ship without employing complex theories such as strip theory, which are dependent on hull forms that are still unknown during the concept design phase. The methodology is based on calculating the Root Mean Square (RMS) of heave and pitch motions in various sea states and ship speeds through Multiple Linear Regressions (MLR), using a database of cruise ships created with the design of experiment (DoE) techniques by varying significant geometric parameters affecting seakeeping performance.
Relonova in the relief of migraine episodes
Authors:   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Filatova E.G. ,   A. Vein Clinic of Headache and Autonomic Disorders, Moscow, Russian Federation, Latysheva N.V. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   A. Vein Clinic of Headache and Autonomic Disorders, Moscow, Russian Federation, Kadymova N.B. ,   A. Vein Clinic of Headache and Autonomic Disorders, Moscow, Russian Federation, Berdnikova A.V. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   A. Vein Clinic of Headache and Autonomic Disorders, Moscow, Russian Federation
Published: November 2024

Aim: to assess the efficacy and safety of the new Russian generic rizatriptan 10 mg tablet in alleviating migraine episodes in a real clinical
practice.
Patients and Methods: an open-label comparative study was conducted involving 30 patients diagnosed with migraine. Each participant was
instructed to treat four migraine episodes (totaling 120 seizures) using rizatriptan 10 mg, administered at the onset of a headache, and to
maintain self-monitoring diaries. If the headache recurred after initial relief, but not sooner than two hours after the first dose, a second tablet
was advised. In cases where rizatriptan provided insufficient analgesic effect, the use of common analgesics was permitted. The study focused
on evaluating both the drug's efficacy and safety profiles.
Results: a total of 102 migraine episodes were successfully treated, while some patients opted out due to perceived insufficient efficacy.
Pain relief or reduction was reported in 86% of episodes two hours post-dose, and in 87% after 24 hours. Complete pain absence was noted
in 45% of episodes two hours after drug administration, and in 68% after 24 hours. A response rate was observed in 63% of participants.
Non-responders, identified as those showing no improvement in at least three episodes, exhibited more severe associated symptoms such as
photophobia and phonophobia, and a marked increase in headache intensity following physical activity. Mild adverse events were reported in
25% of the episodes, resolving spontaneously without the need for additional therapy.
Conclusion: the Russian generic rizatriptan 10 mg tablet was demonstrated to be an effective and safe treatment option for mitigating migraine
episodes.
KEYWORDS: headache, migraine, triptans, relief of migraine episode, rizatriptan, real clinical practice.
FOR CITATION: Filatova E.G., Latysheva N.V., Kadymova N.B., Berdnikova A.V. Relonova in the relief of migraine episodes. Russian Medical
Inquiry. 2024;8(10):560–567 (in Russ.). DOI: 10.32364/2587-6821-2024-8-10-3
Mechanisms of action of vitamins B1, B6 and B12 in chronic primary musculoskeletal pain (case report)
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Solovieva E.Yu. , Filatova I.P. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: November 2024

Pain is a complex of sensory and emotional reactions including nociceptive, nociplastic and neuropathic components. In addition, back pain
associated with musculoskeletal pain syndrome holds a specific (and even leading) place in clinical practice. These patients need comprehensive
individualized therapy. Due to diverse pathophysiological mechanisms of musculoskeletal pain (MSP), new therapeutic approaches including
several targets at once and considering synergy between different analgesics and multiple mechanisms of action focused on nociception
control, are required. A role of neurotropic B vitamins (B1 — thiamine, B6 — pyridoxine and B12 — cyanocobalamin) in the syndrome treatment
has been discussed for a long time. Multiple studies have demonstrated that B vitamins cause antinociceptive, antihyperalgesic and anti-
inflammatory effects, and mitigate mechanical allodynia. Therefore, these drugs affecting a number of physiopathological mechanisms of pain
development are critical to manage various pain-associated conditions.
KEYWORDS: nociception, inflammation, neurotropic B vitamins, thiamine, pyridoxine, cyanocobalamin.
FOR CITATION: Solovieva E.Yu., Filatova I.P. Mechanisms of action of vitamins B1, B6 and B12 in chronic primary musculoskeletal pain (case report). Russian Medical Inquiry. 2024;8(10):592–598 (in Russ.). DOI: 10.32364/2587-6821-2024-8-10-8
Possible causes of phenocopy syndrome in multiple endocrine neoplasia type 1
Authors:   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Trukhina D.A. , Mamedova E.O. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Belaya Zh.E. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation, Melnichenko G.A. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation
Published: November 2024

Multiple endocrine neoplasia type 1 (MEN-1) is a rare autosomal dominant disorder resulting from mutations in the MEN1 gene, which codes for
the menin protein. This syndrome is marked by the development of tumors in the parathyroid glands, gastroenteropancreatic neuroendocrine
tumors, pituitary adenomas, alongside other endocrine and non-endocrine tumors. In 5–10% of individuals exhibiting symptoms of MEN-1, no
mutations are detected in the MEN1 gene; this clinical picture is classified as phenocopy syndrome. In such instances, mutations may reside
in unexamined regions of the MEN1 gene, or alternative gene silencing mechanisms and mutations in other related genes may contribute
to MEN1-associated tumor pathogenesis. Identifying a genetically confirmed MEN-1 syndrome in patients manifesting MEN-1 symptoms
is essential for evaluating tumor development risks and optimizing follow-up protocols. This is particularly important since patients with
genetically confirmed MEN-1 syndrome generally face a reduced life expectancy compared to the broader population and experience a more
aggressive disease progression than those with clinical manifestations of the syndrome without identifiable mutations.
KEYWORDS: multiple endocrine neoplasia type 1, phenocopy, genetics, epigenetics.
FOR CITATION: Trukhina D.A., Mamedova E.O., Belaya Zh.E., Melnichenko G.A. Possible causes of phenocopy syndrome in multiple endocrine neoplasia type 1. Russian Medical Inquiry. 2024;8(9):526–530 (in Russ.). DOI: 10.32364/2587-6821-2024-8-9-4
Penyuluhan keliling mengenai pencegahan stunting di Desa Burai, Ogan Ilir, Indonesia
Authors: Najmah  , Misnaniarti  , Hoirunnisa Najma , Oktaviandi Shanti , Firdaus Zaskia Amirarosa , Putri Yarna Nafisah Shakira , Dea Ariesty Sarila Diva , Firzatulloh Muhammad Buana , Rohmatullah Muhammad Hersyah , Arfi Alzikra , Fauziah Aini , Rahma Nurul , Naomi Christara Cicelia , Putri Sherin Andrea
Published: November 2024

Stunting masih menjadi masalah kompleks yang belum dapat terselesaikan di Indonesia. Berdasarkan hasil Survei Status Gizi Indonesia (SSGI) tahun 2022 ditemukan 21,6% anak balita Indonesia mengalami stunting. Menurut World Health Organization (WHO) stunting didefinisikan sebagai gangguan pertumbuhan dan perkembangan anak akibat kekurangan gizi kronis dan infeksi berulang yang ditandai dengan tinggi badan anak berada di bawah dua standar deviasi dari standar median WHO. Stunting bukan hanya permasalahan gizi yang disebabkan oleh asupan makanan tetapi juga berkaitan erat dengan masalah ekonomi, sanitasi, akses ke pelayanan kesehatan, serta faktor pola asuh. Kampung Pandai Indralaya Season II merupakan upaya edukasi dengan pendekatan penyuluhan keliling baik untuk orang tua maupun anak-anak mengenai pencegahan stunting, personal hygiene, kesehatan gigi serta belajar Bahasa Inggris. Selama kegiatan dilakukan survei mengenai stunting untuk mengukur pengetahuan, sikap, dan perilaku orang tua mengenai pencegahan stunting dengan memberikan kuesioner dan menyebarkan leaflet. Hasil survei dilakukan analisis dengan aplikasi pengolahan data untuk melihat rata-rata nilai pengetahuan, sikap dan perilaku keluarga terhadap pencegahan stunting dengan 70 ibu rumah tangga. Hasil survei menunjukkan pengetahuan baik terkait pencegahan stunting sebanyak 42 orang (60.0%), responden dengan sikap baik sebanyak 43 orang (61.4%) dan responden dengan perilaku yang baik mengenai pencegahan stunting sebanyak 39 orang (55.7%). Mayoritas responden telah memahami pentingnya peran keluarga dalam mendukung pertumbuhan dan perkembangan anak serta mengurangi prevalensi stunting.
Peningkatan pengetahuan masyarakat terkait dengan perilaku hidup bersih dan sehat (PHBS) untuk pencegahan stunting
Authors: Rohmah Nur , Pratiwi Fennysa Indrilla , Salsabila Ashila , Asrianah Asrianah , Rahmawati Cica , Anggraini Devica Novia , Haris Ahmad , Tupa Hildayani Kurlim , Nabila Resha Rizqy , Rismayuti Salsabila Dwi Aulia , Agustini Rina Tri
Published: November 2024

Prevalensi balita stunting di Kalimantan Timur berdasarkan prevalensi stunting nasional berada di angka 37,2%. Kalimantan Timur memiliki proporsi balita stunting pada tahun 2021 yaitu sebesar 26,7%, dan balita yang tergolong pendek sebanyak 18,3% serta tergolong sangat pendek sebesar 8,4%. Pengabdian masyarakat ini bertujuan untuk meningkatkan PHBS sebagai solusi permasalahan kesehatan yang berhubungan dengan isu stunting, merencanakan dan melaksanakan program intervensi untuk mencegah stunting di wilayah kerja RT 03 dan RT 07 Kelurahan Rawa Makmur Kecamatan Palaran Kota Samarinda. Kegiatan ini dilakukan menggunakan teori Dignan and Carr dengan metode CARL. Hasil kegiatan diperoleh permasalahan Perilaku Hidup Bersih dan Sehat sebagai isu permasalahan stunting di wilayah sasaran. Hasil kegiatan pengabdian masyarakat ini telah dilaksanakan 2 program intervensi di wilayah RT 03 dan RT 07 Rawa Makmur yang merupakan indikator dari PHBS diantaranya yaitu pelatihan pemberian ASI dan MP-ASI serta makan buah dan sayur, dan pelatihan cuci tangan pakai sabun. Kesimpulan dari kegiatan ini yaitu terdapat peningkatan rata-rata pengetahuan secara signifikan pada peserta setelah dilakukan pelatihan tersebut (p value 0,001). Diperlukan program keberlanjutan untuk meningkatkan determinan perilaku yang berkaitan dengan penurunan risiko kejadian stunting.
Vorwort
Authors: Rusch Stefanie
Published: November 2024

Bereits die von Friedrich Traugott Wahlen geleitete Arbeitsgruppe
für die Vorbereitung einer Totalrevision
der
Bundesverfassung hielt fest, dass der Föderalismus
nun
dem «Antiquierten»1 angehört. Wer sich, wenn auch ungern,
der Pandemiejahre erinnert, dürfte die Schimpftirade
über den «Flickenteppich», den «Kantönligeist» oder
die «Unzeitgemässheit» des Föderalismus noch nachklingen
hören. Das «am ehesten und am meisten gefährdete
Strukturelement der geltenden Bundesverfassung»2 ist
unter Druck geraten und hat das Gros seiner Attraktivität
verloren. Angesichts der vergangenen und anhaltenden
Krisenjahre möchte die Herausgeberschaft dieser Zeitschrift
der sich abzeichnenden bundesstaatlichen Schwäche
entgegentreten und dem Föderalismus zu neuem
Glanz verhelfen. So widmet sich die vorliegende Ausgabe
dessen schillerndstem Prinzip: der «Subsidiarität».
La subsidiarité : Histoire d’un principe aux fondements ecclésiastiques et de son applicabilité ecclésiale
Authors: Lehmann Mainy Aurélie
Published: November 2024

The apparent tension between hierarchy and subsidiarity within the Catholic Church raises
questions about how the Church applies a principle for which it has laid the foundations for the
society. This article traces the history of the ecclesiastical foundations of the principle of subsidiarity
and explores how this tension manifests itself within the institutional framework of the Church. It
shows that, in its own context, the Church has to balance opposing requirements, reflecting two
sides of the principle of subsidiarity when applied to the State and to itself respectively.
Confiscation des bénéfices issus de destructions de l’environnement : quels défis ?
Authors: Clara Brambilla Clara Brambilla , Marti Elisa
Published: November 2024

The confiscation of profits stemming from environmental destruction sometimes encounters legal
obstacles: their legality, an international character, committed within companies and collaboration
between the various authorities. This contribution aims to identify these obstacles and propose
possible solutions.
Rise of the Robots: Können und sollten Roboter rechtsfähig sein?
Authors: Pullen Jennifer , Brunner Simone
Published: November 2024

This article examines the possibility and appropriateness of granting legal personhood to robots
and autonomous machines. Given the increasing autonomy of robots, the question of responsibility
for their actions arises. The paper proposes a framework to determine whether granting legal
personhood to specific types of technology is feasible and sensible. The article discusses various
approaches to defining artificial intelligence and emphasises the difficulty of establishing a unified
definition. It argues that a technology-based approach should be pursued for regulatory purposes,
as artificial intelligence is an umbrella term for many technologies. Finally, the need to develop clear
criteria for assigning potential legal personhood to robots is stressed. Both technical aspects and
legal and ethical considerations should be taken into account.
Le prédécès et ses avatars
Authors: Liogier de Sereys Louis
Published: November 2024

When an heir dies before the person he is supposed to inherit from, the « predecease system » sets
out certain rules for the devolution of the de cujus’ estate. Five other institutions (renunciation,
disinheritance, unworthiness, disclaimer, substitution) use the « predecease system » in a subsidiary
manner, but with some variations, particularly as regard to the fate of the statutory provision
(réserve), when the predeceased is an heir entitled to a legal provision.