bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenetic significance of single nucleotide polymorphisms in the gastric inhibitory polypeptide receptor gene for the development of carbohydrate metabolism disorders in obesity
Authors: Skuratovskaia Daria S. , Vasilenko Maria A. , Fattakhov Nikolai S. , Kirienkova Elena V. , Mironyuk Natalia I. , Zatolokin Pavel A. , Litvinova Larisa S.
Published: March 2017

Aim. To investigate the association of the GIPR gene polymorphisms rs2302382 and rs8111428 with increased risk of type 2 diabetes mellitus and abdominal obesity.Materials and methods. The study involved 163 patients with abdominal obesity (BMI, 39.5 ± 8.3 kg/m2; age, 44.7 ± 8.9 years; men, 61; women, 102), 72 with type 2 diabetes mellitus (BMI, 43.70 ± 9.32 kg/m2; age, 46.5 ± 10.1 years; men, 29; women, 43) and 91 patients without carbohydrate metabolism disorders (BMI, 36.13 ± 6.72 kg/m2; age, 43.93 ± 8.35 years; men, 32; women 59). The control group comprised 109 relatively healthy volunteers (BMI, 22.6 ± 2.7 kg/m2; age, 39.5 ± 7.6 years; men, 66; women, 43). Genotypes were analysed by real-time PCR and serum insulin and C-peptide levels were evaluated by ELISA.Results. The AA genotype in the rs2302382 polymorphism of GIPR was associated with an increased risk for type 2 diabetes mellitus in abdominal obesity and the CA genotype was associated with a reduced risk. In individuals with abdominal obesity and type 2 diabetes mellitus carrying the CA genotype in rs2302382 polymorphism of GIPR, serum insulin and C-peptide levels were elevated to 56.27 mU/L (55.49–58.41 mU/L) and 2.04 ng/ml (1.37–2.85 ng/ml), respectively (p 0.05). In obese patients with the same genotype and without type 2 diabetes, serum insulin levels and C-peptide levels were 22.73 mU/L (19.07–25.76 mU/L) and 0.73 ng/ml (0.53–1.03 ng/ml), respectively (p 0.05). The GIPR rs8111428 polymorphism was not associated with increased risk of type 2 diabetes mellitus in obesity for any of the groups examined.Conclusion. Serum insulin and C-peptide levels were increased in patients with abdominal obesity who were carriers of the CA genotype in the rs2302382 polymorphism of GIPR, which is associated with a decreased risk of type 2 diabetes mellitus in obesity compared with the CC genotype.
Cornea and its changes in diabetes mellitus: the review
Authors: Bikbov Mukharram M. , Surkova Valentina K.
Published: March 2017

Diabetes mellitus (DM) is the most common endocrine disease, which makes it a priority among health and social problems. Ocular manifestations in diabetes often lead to patient disability. This review presents an analysis of morphological, experimental and clinical studies of the cornea in patients with diabetes mellitus, including original research, reviews and monographs of Russian and foreign authors from recent years. In addition, modern methods of corneal disease diagnosis are reviewed. Clinical and morphological changes in the diabetic cornea are discussed and early diabetic changes in all structural layers are indicated. The importance of changes to nerve fibres in diabetes is discussed and the correlation between the density of nerve fibres in the cornea and the density of epidermal nerve fibres is shown.
Kooperationen von Prosumenten
Authors: Flieger Burghard
Published: March 2017

Erzeuger-Verbraucher-Genossenschaften vereinen Produzenten und Konsumenten unter einem Dach. Durch diese wird das Konzept des Prosumenten in das Genossenschaftsmodell inte griert. Welchen Beitrag leisten diese Genossenschaften zu einer nachhaltigen Entwicklung?
Wertschöpfungsketten neu denken und Barrieren überwinden
Authors: Goldkorn Frederic , Kröger Melanie , Pape Jens
Published: March 2017

Seit 2014 entstehen immer mehr Läden, die Lebensmittel ohne Einwegverpackungen – unverpackt – anbieten. Erste Forschungsergebnisse zeigen, dass das Konzept wichtige Beiträge für einen nachhaltigeren Konsum liefert, für dessen Erfolg aber Wertschöpfungsketten neu gedacht und gestaltet werden müssen.
Geld und Nachhaltigkeit
Authors: Petschow Ulrich , Hofmann David
Published: March 2017

Einführung in das Schwerpunktthema
Finanzmärkte, Klimapolitik und Asset Bubbles
Authors: Hübner Kurt
Published: March 2017

Finanzmärkte versorgen die Wirtschaft mit speziellen Produkten, die die Gegenwart mit der Zukunft verknüpfen. Welche Bedeutung haben Finanzprodukte und Vermögensblasen für die Klimapolitik?
MENAFSIR MASYARAKAT ADAT HATUHAHA AMARIMA DENGAN PENDEKATAN HERMENEUTIKA PAUL RICOEUR DAN SIGNIFIKANSINYA UNTUK HIDUP DALAM PERSAUDARAAN
Authors: A. Uhi Jannes
Published: March 2017

Abstract Hermeneutics is no longer focused on the written text, but has grown and that  concerns to the spoken texts. The development of hermeneutics of interpretation of written text into spoken text is intended to express the meaning behind human actions are not mentioned in the article. Phenomenology indigenous of Hatuhaha Amarima with the culture’s through meaningful when interpreted with Paul Ricoeur's hermeneutic approach. Deepest meaning of phenomenology indigenous of Hatuhaha Amarima useful in establishing a life together in religious differences. Religious differences to provide awareness for indigenous peoples to survive in there al brotherhood became everyone's expectations.   Keywords: hermeneutics, Hatuhaha Amarima, brotherhood
MUWUJUDKAN BUDAYA POLITIK SANTUN, BERSIH DAN BERETIKA DALAM RANGKA MEMPERKOKOH KEHIDUPAN BERBANGSA DAN BERNEGARA
Authors: Widodo Wahyu
Published: March 2017

Abstract Makalah ini membahas konsep budaya politik berpusat pada imajinasi (pikiran dan perasaan) manusia yang merupakan dasar semua tindakan. Dalam rangka menuju arah pembangunan dan modernisasi suatu masyarakat akan menempuh jalan yang berbeda antara satu masyarakat dengan yang lain, dan itu terjadi karena peranan kebudayaan sebagai salah satu faktor. Budaya politik dapat membentuk aspirasi, harapan, preferensi, dan prioritas tertentu dalam menghadapi tantangan yang ditimbulkan oleh perubahan sosial politik. Pada gilirannya, disimpulkan bahwa peran budaya politik santun, bersih dan beretika dalam rangka memperkokoh kehidupan berbangsa dan bernegara menuju Indonesia baru adalah: pertama, etika politik dan pemerintahan mengandung misi kepada setiap pejabat dan elite politik untuk bersikap jujur, amanah, sportif, siap melayani, berjiwa besar, memiliki keteladanan, rendah hati, dan siap untuk mundur dari jabatan publik apabila terbukti melakukan kesalahan dan secara moral kebijakannya bertentangan dengan hukum dan rasa keadilan masyarakat. Kedua, perlu dilakukan upaya penanaman suatu kesadaran bahwa politik yang hendak kita perjuangkan bukan semata politik kekuasaan, melainkan suatu politik yang mengedepankan panggilan pengabdian demi kesejahteraan masyarakat luas, dialektika antara partai dan politikus serta masyarakat yang kritis. Ketiga, budaya politik santun, bersih dan beretika ini diperlukan karena dapat membuat para elite politik menjauhi sikap dan perbuatan yang dapat merugikan bangsa Indonesia. Akhirnya, disarankan agar dilaksanakan kembali pendidikan budi pekerti yang merupakan pondasi bagi pelaksanaan Civic Education agar tercipta generasi yang tidak hanya mau menjadi politisi, namun paham budaya dan etika politik.   Kata kunci: budaya politik, kehidupan berbangsa dan bernegara, menuju Indonesia baru
GENDER PERFORMANCE IN ELIZABETH GASKELL’S RUTH
Authors: Farmacelia Nurulhady Eta
Published: March 2017

Gender adalah konstruksi sosial yang mengikat anggota masyarakat tertentu untuk menampilkan perilaku yang sesuai dengan identitas gendernya. Tulisan ini bertujuan untuk mengkaji tampilan gender dalam novel Ruth karangan Elizabeth Gaskell untuk mengetahui sudut pandang Inggris di era Victoria tentang gender sebagai konstruksi sosial. Tokoh tokoh dalam novel ini harus berperilaku yang sesuai dengan identitas gender mereka. Tokoh utama, Ruth, juga dihakimi berdasarkan tampilan gendernya, dan dia harus menerima hukuman masyarakat ketika dianggap melanggar aturan sebagai seorang perempuan. Dengan usaha sadarnya untuk berperilaku sesuai dengan ekspektasi masyarakat atas seorang perempuan, Ruth berhasil mendapatkan kembali tempat yang terhormat dalam masyarakat. Dari seorang yang dianggap sebagai perempuan jalang, Ruth kemudian dikenal sebagai malaikat penolong. Ruth dipandang berdasarkan identitas gender yang ia tampilkan, dan ia menjadi seorang perempuan yang terhormat dalam masyarakat.   Kata kunci: gender, tampilan gender, konstruksi sosial
Effect of Smoking on Development of New Onset Diabetes Mellitus after Transplantation (NODAT) of Kidney
Authors: Dedinska I , Laca L , Miklusica J , Ulianko J , Janek J , Galajda P , Stancik M , Cellar M , Mokan M
Published: March 2017

Purpose: Cigarette smoking has adverse effects on kidney transplant recipients, causing cardiovascular disease, kidney function impairment, and cancer. New onset diabetes mellitus after transplantation (NODAT) represents serious complication of transplantation of solid organs.

Methods: In the group of 252 patients after kidney transplantation, we identified smokers and current non-smokers (the patient who has not been smoking or who is ex smoker) for the period of minimum 24 months. In the monitored period of 12 months after transplantation, we detected presence of NODAT in both groups. The group contained only those patients who did not have diabetes mellitus (of type 1 and 2) at the time of kidney transplantation.

Results: The group of smokers was composed of 88 patients (34.9 %) and non-smokers 164 patients (65.1 %). The average age of smokers was 52 years ± 12.4, and of current non-smokers it was 44.8 years ± 12.8 (P < 0.0001). The smokers had significantly lower body mass index (BMI) at the time of kidney transplantation (P = 0.0059) and also 12 months after transplantation (P = 0.0069), lower weight gain 12 months after transplantation (P = 0.0220) and larger waist circumference 12 months after transplantation (P < 0.0001).

Conclusion: In our group, smoking had no effect on development of NODAT, the smokers had lower values of BMI and waist circumference, however, the guideline development group feels that, as for the general population, success of smoking cessation can be enhanced by offering structured smoking cessation programs.
Extrusion of root canal sealer in periapical tissues: Report of two cases with different treatment management and literature review
Authors: Dalopoulou Athina , Economides Nikolaos , Evangelidis Vasilis
Published: March 2017

Background: Extrusion of root canal sealers may cause damage to the surrounding anatomic structures. Clinical symptoms like pain, swelling and paresthesia or anesthesia may be present. The purpose of this presentation is to describe two cases of root canal sealer penetration into periapical tissues. A different treatment management was followed in each case. Case reports: A 55 year-old man underwent root canal retreatment of the right mandibular first molar tooth due to a periapical lesion. Postoperative periapical radiographs revealed the presence of root canal sealer (AH26) beyond the apex in the distal root in proximity to the mandibular canal. The patient reported pain for the next 7 days. Radiographic examination after 1 year showed complete healing of the periapical area and a small absorption of the root canal sealer. A 42 year-old woman was referred complained of swelling and pain in the area of the right maxillary first incisor. Radiographic examination showed extrusion of root canal sealer in the periapical area associated with a periapical lesion. Surgical intervention was decided upon, which included removal of the sealer, apicoectomy of the tooth and retrograde filling with MTA. After 1 year, complete healing of the area was observed. Conclusion: In conclusion, cases of root canal sealer extrusion, surgical treatment should be decided on only in association with clinical symptoms or with radiographic evidence of increasing periapical lesion.
The influence of crown ferrule on fracture resistance of endodontically treated maxillary central incisors
Authors: Jovanovski Sasho , Popovski Julie , Dakskobler Alesh , Marion Ljubo , Jevnikar Peter
Published: March 2017

Background: Prefabricated zirconia posts can contribute to increasing the fracture resistance of the endodontically treated teeth. Purpose. This in vitro study compared the fracture resistance of endodontically treated central maxillary incisors prepared with 2mm ferrule length to the ones without ferrule. Material and methods: Twenty-four caries-free maxillary central incisors were divided into 2 groups of 12. In group A circumferential external dentin shoulders were prepared for 2mm external dentin ferrule length. There was no ferrule preparation in Group B. Zirconia VALLPOST BO-S (Ø 1,6mm), Ljubljana, Slovenia were used with retention forms in the coronary part. Core build-up was made of pressed ceramics (IPS e.max Press, Ivoclar, Liechtenstein). Crowns were manufactured from the same ceramic material (IPS e.max Press, Ivoclar). After root canal treatment and post space preparation, all posts were cemented with an adhesive resin cement (Multilink Automix, Ivoclar). The specimens were embedded in acrylic resin blocks (ProBase Polymer/Monomer, Ivoclar) and loaded at an angle of 45o to the long axis in an Instron Testing Machine 4301 (Instron Corp., USA) at a crosshead speed of 1mm/min until fracture. Fracture patterns and loads were recorded. A significance level of p<0.05 was used for all comparisons. Two-way analysis of variance was used for statistical analysis. Failure patterns were analyzed with the optical microscope Stereo Discovery V.8 (Carl Zeiss, Germany) and compared using the chisquare nonparametric test. Results: The mean values (±SD) of fracture loads (N) for the Groups A and B were 664.63N (±49.14) and 519.36N (±71.65) recpectively. Significantly lower failure loads were recorded for the specimens in the group B. Failure patterns within the groups revealed non-catastrophic failure in 70% of the specimens for group A and 85% for group B. Conclusions: Within the limitations of this in vitro study, it can be concluded that zirconia VALLPOST BO-S (Ø 1,6mm) with press-ceramic cores and crowns, can be used for restoration of endodontically treated teeth. The teeth prepared with 2mm external dentin ferrule length were found to be more fracture resistant than teeth without ferrule.
Adams-Olıver syndrome: A case report
Authors: Demiray Fatma , Korkut Emre , Gezgin Onur , Şener Yağmur , Bostancı Büşra
Published: March 2017

Background: Adams-Oliver Syndrome has been described by Adams and Oliver in 1945. Original definition, along with aplasia cutis congenital syndrome and limb defects, has neurological and cardiological problems. In the first description, genetic defect passes variable autosomal dominant pattern. Afterwards the autosomal recessive and sporadic cases were published. Case Report: 11-year old male patient complained of mobile teeth admitted to our clinic. He was noted to have characteristic view with distal-phalanx and nail hypoplasia of his hand and feet with occipital scalp defect. We consulted to genetics because of these findings and learned that he has the Adams-Oliver Syndrome. The patient has some orofacial manifestations including high-narrow palate, fissured tongue, crowding, dysmorphic facial features, facial asymmetry, deep-philtrum, delayed eruption, class III malocclusion. The extraction of mobile deciduous teeth, restoration of caries and also oral hygiene motivation was made. Then, the patient was referred to orthodontics. Conclusions: Adams-Oliver syndrome represents are rare congenital alteration, insufficiently documented in scientific literature. This shows the need to document news cases.
Calabi–Yau and fractional Calabi–Yau categories
Authors: Kuznetsov Alexander
Published: March 2017

We discuss Calabi–Yau and fractional Calabi–Yau semiorthogonal components of derived categories of coherent sheaves on smooth projective varieties.
The main result is a general construction of a fractional Calabi–Yau category from a rectangular Lefschetz decomposition and a spherical functor.
We give many examples of applications of this construction and discuss some general properties of Calabi–Yau categories.
An Active Learning Pedagogy for International Management: Cases in Germany, Mexico, and Ethiopia
Authors: Brice William David , Katzenstein Jim
Published: March 2017

Three very different study abroad visits for US students illustrate limitations of short-term study abroad experiences as well as highlight successful approaches. Lessons can be gained for strategically planning experiences that gain the most cross-cultural learning from short study abroad visits.

Seven US business students attended a two-week business-plan competition in Germany that involved students from six countries. Incidents occurred which could have provided critical cross-cultural learning. Faculty-assisted analysis of these cultural incidents could have been used as teachable moments.

Thirty US business students attended a one-week study visit to Mexico in conjunction with a Mexican university. The students attended economic lectures at the university and visited industrial locations. Students were allowed to do as they wished during free time, without any interaction with host nationals or assisted cultural analysis.

Two US business students journeyed to Ethiopia for a three week visit in conjunction with an Ethiopian business college. The students were involved with in-depth cultural research and intensive interaction with host nationals. Strong gains in cultural understanding were observable.

The thesis of this pedagogical case study is that instructors and program directors should seize upon, and create, the opportunity for unplanned critical incidents. These incidents should not be looked on as problems, difficulties, or bad behavior, but as normal cross-cultural interactions that can teach students more than pre-planned program interactions. Intensive interactions with host nationals in uncontrolled situations, combined with expert analysis, may convey greater cross-cultural learning than controlled formal programs.
“云” 族新词的衍生机制与认知阐释
Authors: 文全 杨 , 昊 杨
Published: March 2017

本文就近年来出现的一大批 “云” 族新词，从其结构形式、音节特征、功能分布和 “云+X” 和 “X+云” 中变量 “X” 的词性等方面进行了多维度的研究，并从语义嬗变与认知阐释的角度做了具体解析，认为 ：“云” 族新词体现了异质语言接触性变异的普遍规律，“云+X” 和 “X+云” 是 “云” 族新词的两种主要结构形式，其语义焦点、语用功能存在着相当差距，同时 “云” 在这两种结构中体现出来的意义、性质和作用也同样存在区别。
Effects of court specific and minimalist footwear on the biomechanics of a maximal 180° cutting manoeuvre
Authors: Sinclair Jonathan Kenneth
Published: March 2017

Purpose

The aim of the current investigation was to examine the effects of different footwear on the kinetics and kinematics of performing a 180° cutting manoeuvre.

Methods

Nine male participants performed maximal 180° cut movements in court shoes, minimalist footwear, energy return, and conventional running shoes. Lower limb kinematic data were collected with the use of an 8 camera motion capture system, ground reaction forces were quantified with an embedded force platform, and tibial accelerations were obtained by means of an accelerometer. Differences in kinetics and kinematics between footwear were examined by one-way repeated measures ANOVA.

Results

The results showed that both instantaneous loading rate and peak tibial acceleration were significantly larger in the minimalist (282.91 BW/s and 6.38 g) and court (326.67 BW/s and 6.35 g) footwear compared with the conventional (143.19 BW/s and 5.46 g) and energy return (106.14 BW/s and 4.98 g) footwear. In addition, peak inversion was revealed to be significantly larger in the minimalist (16.36°) than in conventional (11.86°), court (12.61°), and energy return (10.12°) footwear.

Conclusions

These findings indicate that minimalist and court footwear may place athletes at increased risk from injury when performing 180° cut movements.
Poland and Global Threats
Authors: Kleer Jerzy
Published: March 2017

This essay seeks to present the specifics of global threats, as well as the reasons for them being universal in nature, and for their persistence. A certain classification of the threats is also engaged in. At the same time, an attempt is made to show the specific threats present – irrespective of their global counterparts – in different regions, and even in different states. The genesis and nature of the latter are demonstrated in a somewhat ad hoc manner by reference to the threats considered to face Poland. If the global threats are truly universal, and arise out of the changes taking place around the world in the last half-century (primarily around the twin phenomena of globalisation and the information revolution), a specific reverse kind of situation applies to decolonisation, plus the collapse of the communist system and the transformation into market economies that apply to formerly communist countries. Equally, some at least of the threats facing Poland may have even a longer history, given that they are very much influenced by past economic and political development, as well as the dominant cultural system.
Home-range size of the European wildcat (Felis silvestris silvestris): a report from two areas in Central Italy
Authors: Anile Stefano , Bizzarri Lolita , Lacrimini Moreno , Sforzi Andrea , Ragni Bernardino , Devillard Sebastien
Published: March 2017

Although the behavioural ecology of the European wildcat (Felis silvestris silvestris) has been studied in several European countries, its home-range size is still poorly known due to elusive behaviour of the species living in typically low population densities. In our study, 11 wildcats from two distinct areas, the Maremma Regional Park (Tuscany; 3 males and 1 female) and the Paradiso di Pianciano Estate (Umbria; 6 males and 1 female), both located in Central Italy, were studied by means of classical VHF radio-tracking. Home ranges were calculated by means of the Brownian bridge movement model (BBMM). Variables significantly affecting home-range size were: study area, gender and the interaction between gender*age. The potential effect of the reproductive season and the nocturnal period was not supported. The main findings indicate that: (1) home-range sizes in Tuscany were larger than those in Umbria; (2) home-range size was positively related to the age of individuals; (3) males exploited larger home ranges than females in all age-classes except for the sub-adult age-class; this latter pattern has never emerged from any previous wildcat radio-telemetry study. Population density, different management regimes in the areas considered and the local abundance of prey may explain differences in home-range sizes between the study areas. The estimated home ranges of wildcats in Umbria were slightly larger than those reported across Europe, while those calculated in the Tuscan study area were significantly greater.
Crystal structure of catena-poly[hexakis(μ2-chlorido)-hexakis(4-(1H-pyrazol-5-yl)pyridine-κN)tricadmium(II)], Cd3C48H42Cl6N18
Authors: Xin-Hong Chang , Shi-Hui Li , De-Guang Du
Published: March 2017

Cd3C48H42Cl6N18, monoclinic, C2/c (no. 15), a = 11.4564(7) Å, b = 21.1547(15) Å, c = 21.3475(13) Å, β = 95.192(5)°, V = 5152.5(6) Å3, Z = 4, R
gt(F) = 0.0381, wR
ref(F
2) = 0.1152, T = 293(2) K.
Crystal structure of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-N,N-dimethylformamide (1/1), C18H17NO5
Authors: Lou Benyong , Zhang Mei , Huang Yali , Wu Huazhong
Published: March 2017

C18H17NO5, monoclinic, P21/n (no. 14), a = 6.260(4) Å, b = 20.454(12) Å, c = 12.386(8) Å, β = 97.146(10)°, V = 1573.8(16) Å3, Z = 4, R
gt(F) = 0.0497, wR
ref(F
2) = 0.1214, T = 293 K.
Clinical application of laryngeal electromyography – a point of view
Authors: Pasu Georgiana
Published: March 2017

In recent years, the clinical importance of laryngeal electromyography (LEMG) has been recognized. This method of investigation proved itself to be a valuable and indispensable tool regarding voice disorder management and requires multidisciplinary approach.

In this article, we focus on the clinical usefulness of LEMG to assess inferior and superior motor neuron integrity by recording action potentials generated by muscle fibers of the larynx in the new field known as neurolaryngology. To facilitate the clinical application of this electrophysiologic test, we present a detailed description of LEMG techniques, which were applied for simultaneous bilateral recordings of the thyroarytenoid, cricothyroid and posterior cricoarytenoid muscles. Also, we analysed and measured the following electrophysiological parameters: 1) insertional activity; 2) spontaneous activity; 3) recruitment; 4) morphology of waveform.

From a practical point of view, in our country, LEMG performance is still not a routine procedure in ENT and Phoniatric Departments. The difficulty of practical use of LEMG in Romania consists in technical limitations and it depends on the physician’s experience regarding the examination technique and also the interpretation of electrophysiological results.

Our current clinical experience shows that the use of LEMG contributes especially to the diagnosis, prognosis and treatment of patients with neurolaryngological disorders.
Mutterschaft und die Veränderung der Einstellungen zu Geschlechterungleichheiten
Authors: Liechti Lena
Published: March 2017

Der Beitrag untersucht, wie die Einstellungen zu Geschlechterungleichheiten durch den Übergang in die Mutterschaft beeinflusst werden und ob dabei bildungsspezifische Unterschiede auftreten. Längsschnittanalysen mit Daten des Schweizer Haushalt-Panels zeigen, dass mit der Geburt des ersten Kindes die Wahrnehmung von Frauenbenachteiligungen und die Zustimmung zu Frauenfördermassnahmen steigen. Diese Erhöhung ist allerdings nur von vorübergehender Dauer. Kein klares Muster zeichnet sich bei den bildungsspezifischen Analysen ab.
Angola - an Oil Dependant Country in Sub-Saharan Africa
Authors: Baumgartner Boris
Published: March 2017

The Sub-Saharan Africa belongs to the most underdeveloped regions in the world economy. This region consists of forty nine countries but it’s world GDP share is only a small percentage. There are some very resource rich countries in this region. One of them is Angola. This former Portuguese colony has one of the largest inventories of oil among all African countries. Angola recorded one of the highest growth of GDP between 2004-2008 from all countries in the world economy and nowadays is the third biggest economy in Sub-Saharan Africa after Nigeria and South Africa. The essential problem of Angola is the one-way oriented economy on oil and general on natural resources. Angola will be forced to change their one-way oriented economy to be more diversified and competitive in the future.
Bringing consumption reviews into relief by combining Appraisal and argumentation analysis
Authors: Hommerberg Charlotte
Published: March 2017

Recent years have seen a rapid influx of reviews in the field of different aesthetic and consumption domains, which is indicative of the importance assigned by present-day society to what we choose to experience and consume. Given their prevalence, there is a need to find an adequate analytic framework which allows insightful understanding of the discursive construction of such reviews. This paper aims to propose such a framework by combining tools from the Appraisal model with ideas from argumentation theory. The combined methodology is demonstrated using one text from a corpus of wine reviews written by the extraordinarily influential wine critic Robert Parker. The analysis takes into consideration both meanings that are internal to the text and meanings that are text-external, so-called world knowledge. I argue that the technique of reconstruction adopted from argumentation theory helps to highlight and explain how the appraisal works in the text. The findings are generalizable to the extent that the methodology can be used for any type of review text, especially in the domain of present-day luxury consumption, which is not overtly argumentative but which can still be found to have an assessment-basis format that leads its readers toward a certain worldview that they are invited to co-construct and see as rational.
Stance taking in Japanese Newspaper discourse: the use and non-use of Copulas da and dearu
Authors: Kaneyasu Michiko
Published: March 2017

The present study aims to demonstrate how writers display their stances in information-oriented written discourse. In particular, the paper analyzes nominal sentences in three newspaper subgenres, and explicates how the Japanese copulas
Pragmatic verbal repetition: review and application of a new method of quantification
Authors: Van Lancker Sidtis Diana , Wolf Rachel
Published: March 2017

The use of “pragmatic repetition,” the iteration of one’s own speech or the speech of a co-participant, while known to occur in conversation, has been overlooked in the language sciences. This study presents a method for establishing incidence, characteristics, and functions of pragmatic repetition during conversational exchanges. The method is applied to three discourse samples: a screenplay, a television reality show, and an unscripted telephone conversation. The analysis characterizes each repetition in terms of localness (immediate, delayed, or distant in the discourse); degree of preservation (identical or altered); source (self or other); the linguistic unit (word, phrase, clause, or sentence); and type of phrase (formulaic or novel). Three functional categories were identified: maintaining conversational form, enhancing content, and fostering social purposes. Results indicated that 22% of the telephone conversation and 19% of the reality show conversations constituted repeated material as compared to 9% in the screenplay. Analysis of characteristics and functions of pragmatic repetition revealed significant differences between samples. Findings from this study verify the newly developed quantification methodology, solidify the role of repetition in the pragmatics of language, and lead to better understanding of normal discourse.
Synthesis and characterization of [Cu(salen)]2 coordination nano-assembly by a green and simple method
Authors: Mohammadikish Maryam , Bagheri Fatemeh
Published: March 2017

Hierarchical structured microplates consisting of nanoparticles were grown based on a self-assembly approach via a hydrothermal synthesis route without using any additive. Experimental parameters, such as reaction temperature, time and solvent play crucial roles in determining the morphology of final product. The nanoscale shape and macroscopically assembled architecture of [Cu(salen)]2 {salen = N,N′-bis(salicylidene)1,2-ethyelenediimine} crystals were totally controlled by preparation conditions for crystal growth. The synthesized [Cu(salen)]2 hierarchical architectures were characterized with UV-Vis, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and thermogravimetric (TGA) analyses. The thickness of the fabricated plates changes from 25 nm to 3.5 μm. The as-prepared nanoplates are actually composed of nanoparticles with diameters under 100 nm. Furthermore, the formation mechanism of the microplates decorated with nanorods has also been discussed, based on the influence of the kinetics of nucleation and crystal growth.
Density and Adiabatic Compressibility of the Immiscible Molten AgBr+LiCl Mixture
Authors: Stepanov Victor P. , Kulik Nina P.
Published: March 2017

The adiabatic compressibility, β, of the immiscible liquid mixture 0.52 LiCl+0.48 AgBr (the top of the miscibility gap) was experimentally investigated in the temperature range from the melting point to the critical mixing temperature using the sound velocity values, u, measured by the pulse method, and the density quantities, ρ, which were determined using the hydrostatic weight procedure based on the relationship β=u−

2
ρ−

1. It is shown that the coefficients of the temperature dependencies for the compressibility and density of the upper and lower equilibrium phases have opposite signs because of the superposition of the intensity of the thermal motion of the ions and the change in the composition of the phases. The differences, ∆β and ∆ρ, in the magnitudes of the compressibility and density for the equilibrium phases decrease with temperature elevation. The temperature dependencies of the compressibility and density difference are described using the empirical equations ∆β≈(T
c–T)0.438 and ∆ρ≈(T
c–T)0.439.
Clinical and biochemical characteristics and bone mineral density of homozygous, compound heterozygous and heterozygous carriers of three novel IGFALS mutations
Authors: Işık Emregül , Haliloglu Belma , van Doorn Jaap , Demirbilek Hüseyin , Scheltinga Sitha A , Losekoot Monique , Wit Jan M
Published: March 2017

Objective

Acid-labile subunit (ALS) deficiency (ACLSD), caused by homozygous or compound heterozygous IGFALS mutations, is associated with moderate short stature, delayed puberty, low serum IGF-I and ALS and extremely low serum IGFBP-3. Its effect on birth weight, head circumference, bone mineral density (BMD), serum IGF-II and IGFBP-2 is uncertain, as well as the phenotype of heterozygous carriers of IGFALS mutations (partial ACLSD).

Design

From all available members of five Turkish families, carrying three mutations in exon 2 of IGFALS (c.1462G > A, p.Asp488Asn (families A, B, E); c.251A > G, p.Asn84Ser (families C and E) and c.1477del, p.Arg493fs (family D)), clinical, laboratory and BMD data were collected.

Methods

Auxological and biochemical findings were expressed as SDS for age and gender. Ternary complex formation in serum was investigated by size-exclusion chromatography. BMD using DXA bone densitometry was adjusted for height and age (Ha-BMD z-score).

Results

In ACLSD (n = 24), mean ± s.d. height SDS (−2.7 ± 1.2), head circumference SDS (−2.3 ± 0.5) and body mass index (BMI) (−0.6 ± 1.0 SDS) were lower than those in partial ACLSD (n = 26, P ≤ 0.01) and birth weight SDS (n = 7) tended to be lower (−2.2 ± 1.1 vs −0.6 ± 0.3 in partial ACLSD (P = 0.07)). Serum IGF-I was −3.7 ± 1.4 vs −1.0 ± 1.0, IGF-II: −5.6 ± 0.7 vs −1.3 ± 0.7, ALS: <−4.4 ± 1.2 vs −2.1 ± 0.9 and IGFBP-3: −9.0 ± 1.9 vs −1.6 ± 0.8 SDS respectively (P < 0.001). Ha-BMD z-score was similar and normal in both groups.

Conclusions

To the known phenotype of ACLSD (i.e. short stature, reduced serum levels of IGF-I and ALS, extremely low serum IGFBP-3 and disturbed ternary complex formation), we add reduced birth weight, head circumference and serum IGF-II.
ПАТОЛОГИЯ ЛИЧНОСТИ В ТЕОРЕТИЧЕСКИХ ПОСТРОЕНИЯХ ПРЕДСТАВИТЕЛЕЙ ОТЕЧЕСТВЕННОЙ МЕТАФИЗИЧЕСКОЙ ТРАДИЦИИ В ПСИХОЛОГИИ
Authors: Бреусенко-Кузнецов Александр
Published: March 2017

Статья посвящена проблеме восстановления искусственно прерванной метафизической традиции в отечественной персонологии. Данная проблема принадлежит областям истории психологии и психологии личности, но имеет выходы и в предметные области многих других психологических наук, в частности – клинической психологии. Указана важность соотнесения персонологических концептуализаций учёных-метафизиков с клинической практикой в процессе их опытной верификации. Проведена реконструкция и анализ взглядов на психопатологию и психотерапию представителей метафизической традиции в отечественной психологии личности. Согласно данным взглядам, суть патологии личности – в её уклонении от своего назначения, от подлинного бытия ради неподлинных, онтологически неоправданных форм жизнедеятельности.

The article is devoted to the problem of restoration of artificialy interrupted metaphysical tradition in domestic personology. The given problem belongs to the areas of history of psychology and psychology of personality, but provides outcomes in subject matter of many other psychological sciences, in clinical psychology in particular. Importance of correlation between personological conceptualizations of scientists-metaphysicists and clinical practice in the process of their skilled verification is pointed out. The reconstruction and analysis of views at psychopathology and psychotherapy by representatives of metaphysical tradition in domestic psychology of personality have been made. According to the mentioned views, the essence of pathology of personality is in its evasion from the purpose, from original life for the sake of not original, ontologically unjustified forms of ability to live.
ОСОБЛИВОСТІ ОРГАНІЗАЦІЇ ТА НАДАННЯ ХРИСТИЯНСЬКО-ПСИХОЛОГІЧНОЇ ДОПОМОГИ УЧАСНИКАМ АТО
Authors: Климишин Ольга
Published: March 2017

У статті представлено теоретичне обґрунтування досвіду надання християнсько-психологічної допомоги учасникам АТО. Розкрито суть методологічних засад організації та реалізації християнсько-психологічної допомоги. Описано етапи процесу духовно-психологічної реабілітації учасників бойових дій та специфіку роботи на кожному з них християнського психолога. Вказано особливості психодіагностичного та просвітницького напрямків діяльності. Означено основні завдання психоконсультативних заходів та охарактеризовано особливості простору консультативної взаємодії. Подано авторське бачення функціонального змісту психотерапевтичних заходів як шляхів актуалізації духовного потенціалу з метою задіяння автентичних можливостей подолання наслідків психотравмуючого досвіду.

             The article has the theoretical ground of the experience of supporting of christian-psychological assistance to the participants of АТО. The essence of methodological principles of organization and realization of christian-psychological assistance is marked. The procedure of spiritual-psychological  rehabilitation of participants of battle actions is described, the specific of work of christian psychologist is exposed. The basic tasks of psychoconsultative and educational directions of activities are described. The essence of psychodiagnostic work is exposed. Author’s vision of functional maintenance of psychotherapy measures is given as the way of actualization of spiritual potential with a purpose for the activity of authentic possibilities of overcoming of the consequences of psychotraumatized experience.
Adult Muscle Formation Requires Drosophila Moleskin for Proliferation of Wing Disc-Associated Muscle Precursors
Authors: Vishal Kumar , Brooks David S , Bawa Simranjot , Gameros Samantha , Stetsiv Marta , Geisbrecht Erika R
Published: March 2017

Adult muscle precursor (AMP) cells located in the notum of the larval wing disc undergo rapid amplification and eventual fusion to generate the Drosophila melanogaster indirect flight muscles (IFMs). Here we find that loss of Moleskin (Msk) function in these wing disc-associated myoblasts reduces the overall AMP pool size, resulting in the absence of IFM formation. This myoblast loss is due to a decrease in the AMP proliferative capacity and is independent of cell death. In contrast, disruption of Msk during pupal myoblast proliferation does not alter the AMP number, suggesting that Msk is specifically required for larval AMP proliferation. It has been previously shown that Wingless (Wg) signaling maintains expression of the Vestigial (Vg) transcription factor in proliferating myoblasts. However, other factors that influence Wg-mediated myoblast proliferation are largely unknown. Here we examine the interactions between Msk and the Wg pathway in regulation of the AMP pool size. We find that a myoblast-specific reduction of Msk results in the absence of Vg expression and a complete loss of the Wg pathway readout β-catenin/Armadillo (Arm). Moreover, msk RNA interference knockdown abolishes expression of the Wg target Ladybird (Lbe) in leg disc myoblasts. Collectively, our results provide strong evidence that Msk acts through the Wg signaling pathway to control myoblast pool size and muscle formation by regulating Arm stability or nuclear transport.
Coordination of Double Strand Break Repair and Meiotic Progression in Yeast by a Mek1-Ndt80 Negative Feedback Loop
Authors: Prugar Evelyn , Burnett Cameron , Chen Xiangyu , Hollingsworth Nancy M
Published: March 2017

Meiotic crossovers and double strand breaks (DSBs) are required for gametogenesis, but entering meiotic divisions with broken chromosomes results in...

During meiosis, homologous chromosomes are physically connected by crossovers and sister chromatid cohesion. Interhomolog crossovers are generated by the highly regulated repair of programmed double strand breaks (DSBs). The meiosis-specific kinase Mek1 is critical for this regulation. Mek1 downregulates the mitotic recombinase Rad51, indirectly promoting interhomolog strand invasion by the meiosis-specific recombinase Dmc1. Mek1 also promotes the formation of crossovers that are distributed throughout the genome by interference and is the effector kinase for a meiosis-specific checkpoint that delays entry into Meiosis I until DSBs have been repaired. The target of this checkpoint is a meiosis-specific transcription factor, Ndt80, which is necessary to express the polo-like kinase CDC5 and the cyclin CLB1 thereby allowing completion of recombination and meiotic progression. This work shows that Mek1 and Ndt80 negatively feedback on each other such that when DSB levels are high, Ndt80 is inactive due to high levels of Mek1 activity. As DSBs are repaired, chromosomes synapse and Mek1 activity is reduced below a threshold that allows activation of Ndt80. Ndt80 transcription of CDC5 results in degradation of Red1, a meiosis-specific protein required for Mek1 activation, thereby abolishing Mek1 activity completely. Elimination of Mek1 kinase activity allows Rad51-mediated repair of any remaining DSBs. In this way, cells do not enter Meiosis I until recombination is complete and all DSBs are repaired.
The Nature of Food Commodity Prices Volatility in Driving Inflation and Policy
Authors: Nurliza Nurliza
Published: March 2017

The objective of research is to analyze the volatility effect of food commodity prices and whether surging food commodity prices have spilled over into food inflation and total inflation with time series data through Box-Jenkins method for 12 food commodity prices. The results have proved that only beef price had high volatility effects and have asymmetric effect. While, soybeans, cooking oil, and food are vulnerable but did not have volatility effects. The change in food commodity prices are significant drive the inflation in the long-term although in the short-term insignificant. The government needs to overcome the full transmission effect of an exogenous shock and to introduce economic reform through investment, infrastructure, and markets for corn and egg for food inflation; eggs and peanuts for total inflation. Besides, strong second-round effects of higher commodity prices on inflation have generally been absent converged to core inflation.DOI:  10.15408/sjie.v6i1.4523
Public Debt and Economic Growth in The SouthEast Asian Countries
Authors: Wibowo Muhammad Ghafur
Published: March 2017

This study examines the relationship between public debt and economic growth in eight countries in Southeast Asia that are members of ASEAN. Through the study will contribute reference for each country to establish their macroeconomic policies. Using 10 years of data from 2006 to 2015 and analysis tools Autoregression Vector (VAR), the study attempts to test the theory of finance led growth. The main finding of this study is that public debt is actually able to increase the economic growth of a country significantly, although it takes a few years of its existence. This finding supports several previous studies that demonstrate the important role of government debt to the economy of a country.DOI: 10.15408/sjie.v6i1.4779
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Authors: Signifikan Journal
Published: March 2017

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Genomic Contraindications for Heart Transplantation
Authors: Char Danton S. , Lázaro-Muñoz Gabriel , Barnes Aliessa , Magnus David , Deem Michael J. , Lantos John D.
Published: March 2017

Genome sequencing raises new ethical challenges. Decoding the genome produces new forms of diagnostic and prognostic information; however, the information is often difficult to interpret. The connection between most genetic variants and their phenotypic manifestations is not understood. This scenario is particularly true for disorders that are not associated with an autosomal genetic variant. The analytic uncertainty is compounded by moral uncertainty about how, exactly, the results of genomic testing should influence clinical decisions. In this Ethics Rounds, we present a case in which genomic findings seemed to play a role in deciding whether a patient was to be listed as a transplant candidate. We then asked experts in bioethics and cardiology to discuss the implications of such decisions.
STUDI FREKUENSI PEMBERIAN PAKAN IKAN KERAPU BEBEK (cromileptes attiverrs) DENGAN UKURAN YANG BERBEDA
Authors: Sutarmat Tatam , Ismi Suko , Hanafi Adi , Kawahara Shogo
Published: March 2017

studi frekuensi pemberian pakan ikan kerapu bebek telah dilakukan dalam keramba jaring apung.
PENINGKATAN IMUNITAS YUWANA IKAN KERAPU BEBEK, Cromileptes Altivelis TERHADAP INFEKSI VIRAL NERVOUS NECROSIS (VNN) DENGAN CARA VAKSINASI MELALUI PERENDAMAN
Authors: Roza Des , Johnny Fris , Tridjoko Tridjoko
Published: March 2017

Penelitian dengan tujuan untuk mengetahui pengaruh perbedaan dosis vaksin dan perendaman terhadap ketahanan yuwana kerapu bebek terhadap infeksi VNN, telah dilakukan dilaboratorium Patologi Balai Besar Riset Perikanan Budidaya Laut Gondol
Syntheses, characterisation, photoluminescence and theoretical study of two group 12 phenanthroline complexes
Authors: Zhang Wei-Ming , Wang Ke , Lv Xiang , Sun Fang-Xin , Zhang Chen , Zhang Ding-Wa
Published: March 2017

Two group-12 phenanthroline complexes, namely, mercury (II) chloride (HgCl2)(1,10-phenanthroline) (complex 1) and [cadmium iodide (CdI2)(1,10-phenanthroline)] n (complex 2), have been prepared through solvothermal reactions and structurally characterised by single-crystal X-ray diffraction. Complex 1 features an isolated (zero-dimensional) structure, and the mercury (II) (Hg2+) ion is surrounded by two nitrogen atoms and two chloride ions to form a tetrahedron. Complex 1 crystallises in the space group P21/c of the monoclinic system with four formula units in a cell: a = 3·9712(5), b = 17·847(2), c = 16·688(2) Å, β = 91·938(2)°, V = 1182·1(3) Å3. Complex 2 is characterised by a one-dimensional motif, and the cadmium (II) ion is bound by four iodide ions and two nitrogen atoms to give an octahedron. Complex 2 crystallises in the space group I2/a of the monoclinic system with four formula units in a cell: a = 7·7299(6), b = 11·1309(10), c = 16·3011(12) Å, β = 100·6880(10)°, V = 1378·23(19) Å3. Photoluminescence results reveal that complex 1 shows an emission in the green region, while complex 2 displays an emission in the red region. This theoretical study discovered that the emission of both complexes originates from the ligand-to-ligand charge-transfer transition.
Determining a suitable position for U-turns near signal-controlled road junctions
Authors: Mazaheri Arash , Rahimi Amir Masoud
Published: March 2017

Previous research has shown that vehicles making U-turns at a signal-controlled urban road junction can negatively affect the performance of the junction. This paper reports on a study carried out to determine a suitable position to allow U-turns at signalised intersections in Tehran, Iran, based on their effects on network travel time. A section of the traffic network of Tehran was modelled using specialist software. To make the results more realistic, local traffic and driver behavioural parameters were calibrated and fed into the software. Various scenarios with different intervals were developed, with ten median openings before a signal-controlled junction and ten median openings after the junction. The results indicate that if the median opening for conducting U-turns is located 190 m before the junction, the network delay is lower than the other scenarios considered.