bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of data collection bias of third molar stages of mineralisation for age estimation in the living
Authors: de Oliveira Santos Inês , Baptista Isabel Poiares , da Silva Ricardo Henrique Alves , Cunha Eugénia
Published: January 2024

Age assessment of the living is a fundamental procedure in the process of human identification, in order to guarantee fair treatment of individuals, which has ethical, civil, legal, and medical repercussions. The careful selection of the appropriate methods requires evaluation of several parameters: accuracy, precision of the method, as well as its reproducibility. The approach proposed by Mincer et al. adapted from Demirjian et al. exploring third molar mineralisation, is one of the most frequently considered for age estimation of the living. Thus, this work aims to assess potential bias in the data collection when applying the classification stages for dental mineralisation adapted by Mincer et al. A total of 102 orthopantomographs, of clinical origin, belonging to individuals aged between 12 and 25 years ($ \bar{\textit x} $ = 20.12 years, SD = 3.49 years; 65 females, 37 males, all of Portuguese nationality) were included and a retrospective analysis performed by five observers with different levels of experience (high, average, and basic). The performance and agreement between five observers were evaluated using Weighted Cohen’s Kappa and the Intraclass Correlation Coefficient. To access the influence of impaction on third molar classification, variables were tested using ordinal logistic regression Generalised Linear Model. It was observed that there were variations in the number of teeth identified among the observers, but the agreement levels ranged from moderate to substantial (0.4–0.8). Upon closer examination of the results, it was observed that although there were discernible differences between highly experienced observers and those with less experience, the gap was not as significant as initially hypothesised, and a greater disparity between the classifications of the upper (0.24–0.49) and lower third molars (>0.55) was observed. When bone superimposition is present, the classification process is not significantly influenced; however, variation in teeth angulation affects the assessment. The results suggest that with an efficient preparation, the level of experience as a factor can be overcome. Mincer and colleague's classification system can be replicated with ease and consistency, even though the classification of upper and lower third molars presents distinct challenges.
Genetic regulation of volatile production in two melon introgression line collections with contrasting ripening behavior
Authors: Mayobre Carlos , Santo Domingo Miguel , Özkan Elif Nur , Fernández-Borbolla Andrés , Ruiz-Lasierra Javier , Garcia-Mas Jordi , Pujol Marta
Published: January 2024

The importance of melon aroma in determining fruit quality has been highlighted in recent years. The fruit volatile profile is influenced by the type of fruit ripening. Non-climacteric fruits contain predominantly aldehydes, while climacteric fruits mainly produce esters. Several genes have been described to participate in volatile organic compounds (VOCs) biosynthesis pathways, but knowledge in this area is still incomplete. In this work we analysed the volatile profile of two reciprocal Introgression Line (IL) collections generated from a cross between ‘Piel de Sapo' (PS) and ‘Védrantais’ (VED) melons, differing in their aroma profile and ripening behaviour. SPME GC–MS was performed to identify genes responsible for VOCs formation. More than 1000 QTLs for many volatiles were detected taken together both populations. Introgressions on chromosomes 3, 5, 6, 7 and 8 modified ester-aldehyde balance and were correlated to ripening changes in both genetic backgrounds. Some previously identified QTLs for fruit ripening might be involved in these phenotypes, such as ETHQV8.1 on chromosome 8 and ETHQV6.3 on chromosome 6. PS alleles on chromosomes 2, 6, 10 and 11 were found to increase ester content when introgressed in VED melons. Terpenes showed to be affected by several genomic regions not related to ripening. In addition, several candidate genes have been hypothesized to be responsible for some of the QTLs detected. The analysis of volatile compounds in two reciprocal IL collections has increased our understanding of the relationship between ripening and aroma and offers valuable plant material to improve food quality in melon breeding programs.
Various combinations of living and deceased donors for lung retransplantation—a single institutional retrospective study
Authors: Ohsumi Akihiro , Tanaka Satona , Yamada Yoshito , Yutaka Yojiro , Hamaji Masatsugu , Nakajima Daisuke , Date Hiroshi
Published: January 2024

OBJECTIVES

Lung retransplantation has been performed as a treatment option mainly for chronic lung allograft dysfunction; however, the outcomes of lung retransplantation have been reported to be worse than those of primary lung transplantation. Because of the scarcity of deceased donors in our country, our lung transplant experience includes both living and deceased donors. Therefore, we have experienced lung retransplantation cases with various combinations of living and deceased donors. The aim of this study was to explore technical pitfalls and outcomes of lung retransplantation in this unique environment.

METHODS

We performed 311 lung transplantation procedures between April 2002 and October 2022. Eight lung retransplantation cases (2.6%) were analysed retrospectively.

RESULTS

At lung retransplantation, the age of the recipient patients ranged from 11 to 61 years (median, 33 years). The combinations of donor sources (primary lung transplantation/lung retransplantation) were as follows: 2 living/living, 2 deceased/living, 3 living/deceased and 1 deceased/deceased. Seven of 8 patients received lung retransplantation for chronic lung allograft dysfunction. Hospital death occurred in 2 patients (25.0%). The 1-, 3- and 5-year survival rates after lung retransplantation (n = 8) were 75.0%, 75.0% and 75.0%, respectively, while those after primary lung transplantation (n = 303) were 92.8%, 83.4% and 76.4%, respectively (P = 0.162).

CONCLUSIONS

Lung retransplantation with various combinations of living and deceased donors is a technically difficult but feasible procedure with acceptable outcomes.
Association between early postoperative hypoalbuminaemia and outcome after orthotopic heart transplantation
Authors: M’Pembele René , Roth Sebastian , Jenkins Freya , Hettlich Vincent , Nucaro Anthony , Stroda Alexandra , Tenge Theresa , Polzin Amin , Ramadani Bedri , Lurati Buse Giovanna , Aubin Hug , Lichtenberg Artur , Huhn Ragnar , Boeken Udo
Published: January 2024

OBJECTIVES

In patients undergoing heart transplantation (HTX), preoperative liver impairment and consecutive hypoalbuminaemia are associated with increased mortality. The role of early postoperative hypoalbuminaemia after HTX is unclear. This study investigated the association between early postoperative hypoalbuminaemia and 1-year mortality as well as ‘days alive and out of hospital’ (DAOH) after HTX.

METHODS

This retrospective cohort study included patients who underwent HTX at the University Hospital Duesseldorf, Germany, between 2010 and 2022. The main exposure was serum albumin concentration at intensive care unit (ICU) arrival. The primary endpoints were mortality and DAOH within 1 year after surgery. Receiver operating characteristic (ROC) curve analysis was performed and logistic and quantile regression models with adjustment for 13 a priori defined clinical risk factors were conducted.

RESULTS

Out of 241 patients screened, 229 were included in the analysis (mean age 55 ± 11 years, 73% male). ROC analysis showed moderate discrimination for 1-year mortality by postoperative serum albumin after HTX [AUC = 0.74; 95% confidence interval (CI): 0.66–0.83]. The cutoff for serum albumin at ICU arrival was 3.0 g/dl. According to multivariate logistic and quantile regression, there were independent associations between hypoalbuminaemia and mortality/DAOH [odds ratio of 4.76 (95% CI: 1.94–11.67) and regression coefficient of −46.97 (95% CI: −83.81 to −10.13)].

CONCLUSIONS

Postoperative hypoalbuminaemia <3.0 g/dl is associated with 1-year mortality and reduced DAOH after HTX and therefore might be used for early postoperative risk re-assessment in clinical practice.
On the pursuit to reconstitute the Escherichia coli ribosome from purified components
Authors: Taguchi Hideki
Published: January 2024

The ribosome, the protein synthesizing machinery composed of dozens of proteins and several ribosomal RNAs (rRNAs), is essential for life. In vitro reconstitution of the ribosome holds significance for understanding biosynthesis, applications in biotechnology and potential contributions to synthetic biology. There is a long history of in vitro reconstitution of bacterial ribosomes, originating in the 1970s when the 30S ribosome of Escherichia coli was reconstituted from the protein and rRNA components prepared from native ribosome. Since then, the reconstitution using in vitro transcribed rRNAs has been established, and more recently, the reconstitution using recombinant ribosomal proteins has also become possible. A recent report by Aoyama et al. (J. Biochem. 2022; 171:227–237), the reconstitution of the 50S ribosome using 33 recombinant ribosomal proteins, is a new leap toward complete reconstitution of the holo ribosome complex from recombinant proteins and in vitro transcribed rRNAs. This commentary also discusses future challenges.
Boosting aquila optimizer by marine predators algorithm for combinatorial optimization
Authors: Wang Shuang , Jia Heming , Hussien Abdelazim G , Abualigah Laith , Lin Guanjun , Wei Hongwei , Lin Zhenheng , Dhal Krishna Gopal
Published: January 2024

In this study, an improved version of aquila optimizer (AO) known as EHAOMPA has been developed by using the marine predators algorithm (MPA). MPA is a recent and well-behaved optimizer with a unique memory saving and fish aggregating devices mechanism. At the same time, it suffers from various defects such as inadequate global search, sluggish convergence, and stagnation of local optima. However, AO has contented robust global exploration capability, fast convergence speed, and high search efficiency. Thus, the proposed EHAOMPA aims to complement the shortcomings of AO and MPA while bringing new features. Specifically, the representative-based hunting technique is incorporated into the exploration stage to enhance population diversity. At the same time, random opposition-based learning is introduced into the exploitation stage to prevent the optimizer from sticking to local optima. This study tests the performance of EHAOMPA’s on 23 standard mathematical benchmark functions, 29 complex test functions from the CEC2017 test suite, six constrained industrial engineering design problems, and a convolutional neural network hyperparameter (CNN-hyperparameter) optimization for Corona Virus Disease 19 (COVID-19) computed tomography-image detection problem. EHAOMPA is compared with four existing optimization algorithm types, achieving the best performance on both numerical and practical issues. Compared with other methods, the test function results demonstrate that EHAOMPA exhibits a more potent global search capability, a higher convergence rate, increased accuracy, and an improved ability to avoid local optima. The excellent experimental results in practical problems indicate that the developed EHAOMPA has great potential in solving real-world optimization problems. The combination of multiple strategies can effectively improve the performance of the algorithm. The source code of the EHAOMPA is publicly available at https://github.com/WangShuang92/EHAOMPA.
Trastuzumab deruxtecan in patients with human epidermal growth factor receptor 2–expressing salivary gland carcinoma: a pooled analysis of two phase I studies
Authors: Takahashi Shunji , Bando Hideaki , Kinoshita Ichiro , Modi Shanu , Tsurutani Junji , Bang Yung-Jue , Sato Yuta , Nakatani Shunsuke , Lee Caleb , Sugihara Masahiro , Okuda Yasuyuki , Iwata Hiroji
Published: January 2024

Background

HER2-expressing salivary gland carcinoma (SGC) is associated with poor prognosis. Trastuzumab deruxtecan (T-DXd, DS-8201) has shown evidence of antitumor activity for several HER2-expressing solid tumors in multiple studies. This study aimed to present the efficacy and safety of T-DXd in patients with HER2-expressing SGC from a pooled analysis.

Methods

Patients with HER2-expressing SGC were pooled from two phase I, open-label studies of T-DXd: a two-phase, multiple-dose, first-in-human study (NCT02564900) and a single-sequence crossover drug–drug interaction study (NCT03383692). Endpoints included efficacy (objective response rate [ORR], duration of response [DoR] and progression-free survival [PFS]) and safety.

Results

This pooled analysis included 17 patients with SGC (median age: 57 years; male: 88.2%); median (range) follow-up duration was 12.0 (2.3–‍34.8) months. Among these patients, 14 had received prior HER2-targeted agents and 13 had undergone prior radiotherapy. The investigator-assessed confirmed ORR was 58.8% (95% confidence interval [CI], 32.9–‍81.6). The median (95% CI) DoR and PFS were 17.6 months (4.0 to not evaluable [NE]) and 20.5 months (11.1–NE), respectively. All 17 patients reported treatment-emergent adverse events (TEAEs); 76.5% reported TEAEs of grade ≥3. The most common TEAEs were decreased appetite (94.1%), nausea (88.2%) and neutrophil count decreased (76.5%). Of the 17 patients, five (29.4%) reported adjudicated drug-related interstitial lung disease (grade 1, n = 3; grade 2, n =1; grade 3, n = 1).

Conclusion

The results of this pooled analysis provide evidence that clinical benefit is achievable with T-DXd in patients with HER2-expressing SGC.

Clinical trial information

FIH study, NCT02564900; DDI study, NCT03383692
Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations
Authors: Maillard Maud , Nishii Rina , Yang Wenjian , Hoshitsuki Keito , Chepyala Divyabharathi , Lee Shawn H R , Nguyen Jenny Q , Relling Mary V , Crews Kristine R , Leggas Mark , Singh Meenu , Suang Joshua L Y , Yeoh Allen E J , Jeha Sima , Inaba Hiroto , Pui Ching-Hon , Karol Seth E , Trehan Amita , Bhatia Prateek , Antillon Klussmann Federico G , Bhojwani Deepa , Haidar Cyrine E , Yang Jun J
Published: January 2024

Background

Thiopurines such as mercaptopurine (MP) are widely used to treat acute lymphoblastic leukemia (ALL). Thiopurine-S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) inactivate thiopurines, and no-function variants are associated with drug-induced myelosuppression. Dose adjustment of MP is strongly recommended in patients with intermediate or complete loss of activity of TPMT and NUDT15. However, the extent of dosage reduction recommended for patients with intermediate activity in both enzymes is currently not clear.

Methods

MP dosages during maintenance were collected from 1768 patients with ALL in Singapore, Guatemala, India, and North America. Patients were genotyped for TPMT and NUDT15, and actionable variants defined by the Clinical Pharmacogenetics Implementation Consortium were used to classify patients as TPMT and NUDT15 normal metabolizers (TPMT/NUDT15 NM), TPMT or NUDT15 intermediate metabolizers (TPMT IM or NUDT15 IM), or TPMT and NUDT15 compound intermediate metabolizers (TPMT/NUDT15 IM/IM). In parallel, we evaluated MP toxicity, metabolism, and dose adjustment using a Tpmt/Nudt15 combined heterozygous mouse model (Tpmt+/−/Nudt15+/−).

Results

Twenty-two patients (1.2%) were TPMT/NUDT15 IM/IM in the cohort, with the majority self-reported as Hispanics (68.2%, 15/22). TPMT/NUDT15 IM/IM patients tolerated a median daily MP dose of 25.7 mg/m2 (interquartile range = 19.0-31.1 mg/m2), significantly lower than TPMT IM and NUDT15 IM dosage (P < .001). Similarly, Tpmt+/−/Nudt15+/− mice displayed excessive hematopoietic toxicity and accumulated more metabolite (DNA-TG) than wild-type or single heterozygous mice, which was effectively mitigated by a genotype-guided dose titration of MP.

Conclusion

We recommend more substantial dose reductions to individualize MP therapy and mitigate toxicity in TPMT/NUDT15 IM/IM patients.
Recreational substance use among international travellers
Authors: Charoensakulchai Sakarn , Onwan Manasvin , Kanchanasurakit Sukrit , Flaherty Gerard , Matsee Wasin
Published: January 2024

Background

Drug tourism reflects the expanding illicit drug market, posing health risks in unfamiliar travel settings. Existing knowledge specifically addressing substance use among international travellers is sparse and has not been reviewed to date. This review aimed to describe the recreational substance abuse in international travellers.

Methods

A literature search was conducted on PubMed, Google Scholar and Scopus using keywords related to recreational substances and international travellers. A total of 11 021 articles were reviewed, charted and summarized for the evidence on prevalence, patterns and characteristics of substance abuse and their health- and non-health-related problems on international travellers.

Results

A total of 58 articles were included. Most were cross-sectional studies and review articles. In total, 20 articles addressed the prevalence of substance abuse in travellers, 33 looked at characteristics and patterns of substance abuse in travellers and 39 investigated the health- and non-health-related problems from substance abuse. Estimated prevalence of recreational substances abuse varied from 0.7% to 55.0%. Rates of substances abuse were 9.45–34.5% for cannabis, 20.4–35.9% for alcohol intoxication, 2.82–40.5% for MDMA, 2–22.2% for cocaine, 2–15% for psychedelic agents and 2% for methamphetamine. The prevalence varied according to travellers’ characteristics and travel destinations. Direct health problems included neuropsychiatric problems. Indirect problems included accident and unintentional injuries, crime and violence, risky sexual behaviours and sexual violence and blood-borne infections. Non-health-related problems included air rage, deportation and violation of local laws.

Conclusion

Substance abuse among international travellers is an underestimated problem that requires intervention. These findings emphasize the importance of addressing this issue to mitigate both health and well-being problems among travellers whilst promoting safer and more responsible travel experiences. In the context of travel health practices, practitioners should counsel travellers whose itineraries may include substance abuse, informing them about associated risks and consequences.
Deep cutaneous mycoses in kidney transplant recipients: Diagnostic and therapeutic challenges
Authors: Bertin Chloé , Sitterlé Emilie , Scemla Anne , Fraitag Sylvie , Delliere Sarah , Guegan Sarah , Hermoso Dea Garcia , Leclerc-Mercier Stéphanie , Rouzaud Claire , Lanternier Fanny , Bougnoux Marie-Elisabeth
Published: January 2024

Deep cutaneous mycoses (DCMs) are rare infections that extend throughout the dermis and subcutis, often occurring after inoculation with pathogenic fungi. Trends toward a growing incidence have been observed that may be partially related to an increasing population of solid organ transplant patients. The aim of this study is to describe the diagnostics and the outcomes of DCM among kidney transplant recipients so as to optimize their management. We performed a retrospective review of cases of DCM occurring among kidney transplant recipients in our institution over 12 years. Twenty cases were included. Lesions were only located on the limbs and presented mainly as single (10/20, 50%) nodular lesions (15/20, 75%), with a mean size of 3 cm. Direct mycological examination was positive for 17 patients (17/20, 85%) and the cultures were consistently positive. Thirteen different fungal species were observed, including phaehyphomycetes (n = 8), hyalohyphomycetes (n = 3), dermatophytes (n = 1), and mucorale (n = 1). The (1-3) beta-D-glucan antigen (BDG) was also consistently detected in the serum (20/20, 100%). Systematic imaging did not reveal any distant infectious lesions, but locoregional extension was present in 11 patients (11/14, 79%). Nineteen patients received antifungal treatment (19/20, 95%) for a median duration of 3 months, with surgery for 10 (10/20, 50%). There is a great diversity of fungal species responsible for DCMs in kidney transplant recipients. The mycological documentation is necessary to adapt the antifungal treatment according to the sensitivity of the species. Serum BDG positivity is a potentially reliable and useful tool for diagnosis and follow-up.
Impact of PSF misestimation and galaxy population bias on precision shear measurement using a CNN
Authors: Voigt L M
Published: January 2024

Weak gravitational lensing of distant galaxies provides a powerful probe of dark energy. The aim of this study is to investigate the application of convolutional neural networks (CNNs) to precision shear estimation. In particular, using a shallow CNN, we explore the impact of point spread function (PSF) misestimation and ‘galaxy population bias’ (including ‘distribution bias’ and ‘morphology bias’), focusing on the accuracy requirements of next generation surveys. We simulate a population of noisy disc and elliptical galaxies and adopt a PSF that is representative of a Euclid-like survey. We quantify the accuracy achieved by the CNN, assuming a linear relationship between the estimated and true shears and measure the multiplicative (m) and additive (c) biases. We make use of an unconventional loss function to mitigate the effects of noise bias and measure m and c when we use either: (i) an incorrect galaxy ellipticity distribution or size–magnitude relation, or the wrong ratio of morphological types, to describe the population of galaxies (distribution bias); (ii) an incorrect galaxy light profile (morphology bias); or (iii) a PSF with size or ellipticity offset from its true value (PSF misestimation). We compare our results to the Euclid requirements on the knowledge of the PSF model shape and size. Finally, we outline further work to build on the promising potential of CNNs in precision shear estimation.
Assessing mass-loss and stellar-to-halo mass ratio of satellite galaxies: a galaxy–galaxy lensing approach utilizing DECaLS DR8 data
Authors: Wang Chunxiang , Li Ran , Shan Huanyuan , Xu Weiwei , Yao Ji , Jing Yingjie , Gao Liang , Li Nan , Xie Yushan , Zhu Kai , Yang Hang , Chen Qingze
Published: January 2024

The galaxy–galaxy lensing technique allows us to measure the subhalo mass of satellite galaxies, studying their mass-loss and evolution within galaxy clusters and providing direct observational validation for theories of galaxy formation. In this study, we use the weak gravitational lensing observations from Dark Energy Spectroscopic Instrument (DESI) Legacy Imaging Surveys DR8, in combination with the redMaPPer galaxy cluster catalogue from Sloan Digital Sky Survey (SDSS) DR8 to accurately measure the dark matter halo mass of satellite galaxies. We confirm a significant increase in the stellar-to-halo mass ratio of satellite galaxies with their halo-centric radius, indicating clear evidence of mass-loss due to tidal stripping. Additionally, we find that this mass-loss is strongly dependent on the mass of the satellite galaxies, with satellite galaxies above $10^{11}~{{\rm M}_{\odot }}\, h^{-1}$ experiencing more pronounced mass-loss compared to lower mass satellites, reaching 86 per cent at projected halo-centric radius 0.5R200c. The average mass-loss rate, when not considering halo-centric radius, displays a U-shaped variation with stellar mass, with galaxies of approximately $4\times 10^{10}~{{\rm M}_{\odot }}\, h^{-1}$ exhibiting the least mass-loss, around 60 per cent. We compare our results with state-of-the-art hydrodynamical numerical simulations and find that the satellite galaxy stellar-to-halo mass ratio in the outskirts of galaxy clusters is higher compared to the predictions of the Illustris-TNG project about factor 5. Furthermore, the Illustris-TNG project’s numerical simulations did not predict the observed dependence of satellite galaxy mass-loss rate on satellite galaxy mass.
The self-organized criticality behaviours of two new parameters in SGR J1935+2154
Authors: Xiao Shuo , Zhang Shuang-Nan , Xiong Shao-Lin , Wang Ping , Li Xiu-Juan , Dong Ai-Jun , Zhi Qi-Jun , Li Di
Published: January 2024

The minimum variation time-scale (MVT) and spectral lag of hundreds of X-ray bursts (XRBs) from soft gamma-ray repeater (SGR) J1935+2154 were analysed in detail for the first time in our recent work, which are important probes for studying the physical mechanism and radiation region. In this work, we investigate their differential and cumulative distributions carefully and find that they follow power-law models. Besides, the distributions of fluctuations in both parameters follow the Tsallis q-Gaussian distributions and the q values are consistent for different scale intervals. Therefore, these results indicate that both parameters are scale-invariant, which provides new parameters for the study of self-organized criticality systems. Interestingly, we find that the q values for MVT and spectral lag are similar with duration and fluence, respectively.
Angular complexity in strong lens substructure detection
Authors: O’Riordan Conor M , Vegetti Simona
Published: January 2024

Strong gravitational lensing can be used to find otherwise invisible dark matter subhaloes. In such an analysis, the lens galaxy mass model is a significant source of systematic uncertainty. In this paper, we analyse the effect of angular complexity in the lens model. We use multipole perturbations that introduce low-order deviations from pure ellipticity in the isodensity contours, keeping the radial density profile fixed. We find that, in Hubble Space Telescope-like data, multipole perturbations consistent with those seen in galaxy isophotes are very effective at causing false positive substructure detections. We show that the effectiveness of this degeneracy depends on the deviation from a pure ellipse and the lensing configuration. We find that, when multipoles of 1 per cent are allowed in the lens model, the area in the observation where a subhalo could be detected drops by a factor of 3. Sensitivity away from the lensed images is mostly lost. However, the mass limit of detectable objects on or close to the lensed images does not change. We do not expect the addition of multipole perturbations to lens models to have a significant effect on the ability of strong lensing to constrain the underlying dark matter model. However, given the high rate of false positive detections, angular complexity beyond the elliptical power law should be included for such studies to be reliable. We discuss implications for previous detections and future work.
Spectroscopic diagnostic of the footpoints of the cool loops
Authors: Babu B Suresh , Kayshap Pradeep , Tripathi Sharad C , Jelínek P , Dwivedi B N
Published: January 2024

Statistically, the cool loop’s footpoints are diagnosed using Si iv resonance lines observations provided by Interface Region Imaging Spectrograph (IRIS). The intensity and full width at half-maximum (FWHM) of the loop’s footpoints in β–γ active regions (ARs) are higher than the corresponding parameters of footpoints in β ARs. However, the Doppler velocity of footpoints in both ARs are almost similar to each other. The intensities of footpoints from β–γ AR is found to be around nine times that of β AR when both ARs are observed nearly at the same time. The same intensity difference reduces nearly to half (four times) when considering all ARs observed over 9 yr. Hence, the instrument degradation affects comparative intensity analysis. We find that Doppler velocity and FWHM are well correlated while peak intensity is neither correlated with Doppler velocity nor FWHM. The loop’s footpoints in β–γ ARs have around four times more complex Si iv spectral profiles than that of β ARs. The intensity ratios (Si iv 1393.78 Å/1402.77 Å) of the significant locations of footpoints differ, marginally, (i.e. either less than 1.9 or greater than 2.10) from the theoretical ratio of 2, i.e. 52 per cent (55 per cent) locations in β (β–γ) ARs significantly deviate from 2. Hence, we say that more than half of the footpoint locations are either affected by the opacity or resonance scattering. We conclude that the nature and attributes of the footpoints of the cool loops in β–γ ARs are significantly different from those in β ARs.
MIGHTEE polarization early science fields: the deep polarized sky
Authors: Taylor A R , Sekhar S , Heino L , Scaife A M M , Stil J , Bowles M , Jarvis M , Heywood I , Collier J D
Published: January 2024

The MeerKAT International GigaHertz Tiered Extragalactic Exploration (MIGHTEE) is one of the MeerKAT large survey projects, designed to pathfind SKA key science. MIGHTEE is undertaking deep radio imaging of four well-observed fields (COSMOS, XMM-LSS, ELAIS S1, and CDFS) totaling 20 square degrees to μJy sensitivities. Broad-band imaging observations between 880 and1690 MHz yield total intensity continuum, spectro-polarimetry, and atomic hydrogen spectral imaging. Early science data from MIGHTEE are being released from initial observations of COSMOS and XMM–LSS. This paper describes the spectro-polarimetric observations, the polarization data processing of the MIGHTEE early science fields, and presents polarization data images and catalogues. The catalogues include radio spectral index, redshift information, and Faraday rotation measure synthesis results for 13 267 total intensity radio sources down to a polarized intensity detection limit of ∼20 μJy bm−1. Polarized signals were detected from 324 sources. For the polarized detections, we include a catalogue of Faraday Depth from both Faraday Synthesis and Q, U fitting, as well as total intensity and polarization spectral indices. The distribution of redshift of the total radio sources and detected polarized sources are the same, with median redshifts of 0.86 and 0.82, respectively. Depolarization of the emission at longer-wavelengths is seen to increase with decreasing total-intensity spectral index, implying that depolarization is intrinsic to the radio sources. No evidence is seen for a redshift dependence of the variance of Faraday depth.
Optimal 1D Ly α forest power spectrum estimation – III. DESI early data
Authors: Karaçaylı Naim Göksel , Martini Paul , Guy Julien , Ravoux Corentin , Abdul Karim Marie Lynn , Armengaud Eric , Walther Michael , Aguilar J , Ahlen S , Bailey S , Bautista J , Beltran S F , Brooks D , Cabayol-Garcia L , Chabanier S , Chaussidon E , Chaves-Montero J , Dawson K , de la Cruz R , de la Macorra A , Doel P , Font-Ribera A , Forero-Romero J E , Gontcho S Gontcho A , Gonzalez-Morales A X , Gordon C , Herrera-Alcantar H K , Honscheid K , Iršič V , Ishak M , Kehoe R , Kisner T , Kremin A , Landriau M , Le Guillou L , Levi M E , Lukić Z , Meisner A , Miquel R , Moustakas J , Mueller E , Muñoz-Gutiérrez A , Napolitano L , Nie J , Niz G , Palanque-Delabrouille N , Percival W J , Pieri M , Poppett C , Prada F , Pérez-Ràfols I , Ramírez-Pérez C , Rossi G , Sanchez E , Seo H , Sinigaglia F , Tan T , Tarlé G , Wang B , Weaver B A , Yéche C , Zhou Z
Published: January 2024

The 1D power spectrum P1D of the Ly α forest provides important information about cosmological and astrophysical parameters, including constraints on warm dark matter models, the sum of the masses of the three neutrino species, and the thermal state of the intergalactic medium. We present the first measurement of P1D with the quadratic maximum likelihood estimator (QMLE) from the Dark Energy Spectroscopic Instrument (DESI) survey early data sample. This early sample of 54 600 quasars is already comparable in size to the largest previous studies, and we conduct a thorough investigation of numerous instrumental and analysis systematic errors to evaluate their impact on DESI data with QMLE. We demonstrate the excellent performance of the spectroscopic pipeline noise estimation and the impressive accuracy of the spectrograph resolution matrix with 2D image simulations of raw DESI images that we processed with the DESI spectroscopic pipeline. We also study metal line contamination and noise calibration systematics with quasar spectra on the red side of the Ly α emission line. In a companion paper, we present a similar analysis based on the Fast Fourier Transform estimate of the power spectrum. We conclude with a comparison of these two approaches and discuss the key sources of systematic error that we need to address with the upcoming DESI Year 1 analysis.
Parameter dependency on the public X-ray reverberation models kynxilrev and kynrefrev
Authors: Khanthasombat K , Chainakun P , Young A J
Published: January 2024

We present a comparative study of the constrained parameters of active galactic nuclei (AGN) made by the public X-ray reverberation model kynxilrev and kynrefrev that make use of the reflection code xillver and reflionx, respectively. By varying the central mass (MBH), coronal height (h), inclination (i), photon index of the continuum emission (Γ), and source luminosity (L), the corresponding lag-frequency spectra can be produced. We select only the simulated AGN, where their lag amplitude (τ) and MBH follow the known mass-scaling law. In these mock samples, we show that τ and h are correlated and can possibly be used as an independent scaling law. Furthermore, h (in gravitational units) is also found to be positively scaled with MBH, suggesting a more compact corona in lower-mass AGN. Both models reveal that the coronal height mostly varies between ∼5 and 15 rg, with the average height at ∼10 rg and can potentially be found from low- to high-mass AGN. Nevertheless, the kynxilrev seems to suggest a lower MBH and h than the kynrefrev. This inconsistency is more prominent in lower-spin AGN. The significant correlation between the source height and luminosity is revealed only by kynrefrev, suggesting the h–L relation is probably model-dependent. Our findings emphasize the differences between these reverberation models that raises the question of biases in parameter estimates and inferred correlations.
Simulating image coaddition with the Nancy Grace Roman Space Telescope – II. Analysis of the simulated images and implications for weak lensing
Authors: Yamamoto Masaya , Laliotis Katherine , Macbeth Emily , Zhang Tianqing , Hirata Christopher M , Troxel M A , Cao Kaili , Choi Ami , Givans Jahmour , Heitmann Katrin , Ishak Mustapha , Jarvis Mike , Kovacs Eve , Long Heyang , Mandelbaum Rachel , Park Andy , Porredon Anna , Walter Christopher W , Wood-Vasey W Michael
Published: January 2024

One challenge for applying current weak lensing analysis tools to the Nancy Grace Roman Space Telescope is that individual images will be undersampled. Our companion paper presented an initial application of Imcom – an algorithm that builds an optimal mapping from input to output pixels to reconstruct a fully sampled combined image – on the Roman image simulations. In this paper, we measure the output noise power spectra, identify the sources of the major features in the power spectra, and show that simple analytic models that ignore sampling effects underestimate the power spectra of the coadded noise images. We compute the moments of both idealized injected stars and fully simulated stars in the coadded images, and their one- and two-point statistics. We show that the idealized injected stars have root-mean-square ellipticity errors (1–6) × 10−4 per component depending on the band; the correlation functions are ≥2 orders of magnitude below requirements, indicating that the image combination step itself is using a small fraction of the overall Roman second moment error budget, although the fourth moments are larger and warrant further investigation. The stars in the simulated sky images, which include blending and chromaticity effects, have correlation functions near the requirement level (and below the requirement level in a wide-band image constructed by stacking all four filters). We evaluate the noise-induced biases in the ellipticities of injected stars, and explain the resulting trends with an analytical model. We conclude by enumerating the next steps in developing an image coaddition pipeline for Roman.
A co-rotating gas and satellite structure around the interacting galaxy pair NGC 4490/85
Authors: Karachentsev Igor D , Kroupa Pavel
Published: January 2024

The interacting binary system NGC 4490/85 = Arp 269 is intermediate in mass between the Milky Way/Large Magellanic Cloud and the Large/Small Magellanic Cloud binary systems. It is a system of 14 known galaxies. We estimate the total Newtonian gravitating mass of the NGC 4490/85 group to be $M_\mathrm{ T} = (1.37\pm 0.43) \times 10^{12} \, \mathrm{M}_{\odot }$ using radial velocities and projected separations of its 13 candidate members. The system of dwarf satellites in the group demonstrates signs of coherent rotation in the same direction as that of the extended H i-shell surrounding the central interacting galaxy pair. The origin of this phase-space correlated population of star-forming late-type satellite galaxies raises questions in view of the planes-of-satellites observed around more massive galaxy pairs that are, however, made up of old early-type dwarf galaxies. We also report the detection of a candidate stellar Plume near the binary. This elongated structure of low surface brightness is a likely optical counterpart to the H i-tail north of NGC 4490/85, recently discovered by the Five-Hundred-meter Aperture Spherical radio telescope.
SRG/ART-XC Galactic Bulge deep survey. II. Catalogue of point sources
Authors: Semena A , Mereminskiy I , Lutovinov A , Sazonov S , Arefiev V , Borisov K , Burenin R , Buntov M , Garanin S , Garin M , Grigorovich S , Karasev D , Krivonos R , Levin V , Lapshov I , Molkov S , Pavlinsky M , Shtykovsky A , Semena N , Sunyaev R , Tkachenko A , Vikhlinin A , Voron V
Published: January 2024

We present a catalogue of point sources detected with the Mikhail Pavlinsky ART-XC telescope onboard the SRG observatory during a wide-field survey of the Galactic Bulge that was conducted as part of the mission’s calibration and performance verification phase in 2019. The survey consisted of nearly 18 d of consecutive scanning observations of the sky region |l| < 6 deg, |b| < 2.5 deg with the median sensitivity of 4 × 10−13 erg s−1 cm−2 in the 4–12 keV energy band, which allows the detection of sources down to a luminosity of 3 × 1033 erg s−1 near the Galactic Centre. Using a maximum-likelihood-based algorithm, 172 sources were detected. Of these, 153 are registered on the average 4–12 keV map and 18 sources are either extremely hard (detected only at energies above 7 keV) or highly variable (detected only in individual scans shorter than a day). For 121 sources, there are plausible counterparts in other X-ray source catalogues, including 43 with known classification. The remaining 51 sources are previously unknown objects, discovered by ART-XC during the Galactic Bulge survey.
The pulsar magnetosphere with machine learning: methodology
Authors: Dimitropoulos I , Contopoulos I , Mpisketzis V , Chaniadakis E
Published: January 2024

In this study, we introduce a novel approach for deriving the solution of the ideal force-free steady-state pulsar magnetosphere in three dimensions. Our method involves partitioning the magnetosphere into the regions of closed and open field lines, and subsequently training two custom Physics Informed Neural Networks to generate the solution within each region. We periodically modify the shape of the boundary separating the two regions (the separatrix) to ensure pressure balance throughout. Our approach provides an effective way to handle mathematical contact discontinuities in force-free electrodynamics. We present preliminary results in axisymmetry, which underscore the significant potential of our method. Finally, we discuss the challenges and limitations encountered while working with Neural Networks, thus providing valuable insights from our experience.
The effect of relativistic precession on light curves of tidal disruption events
Authors: Calderón Diego , Pejcha Ondřej , Metzger Brian D , Duffell Paul C
Published: January 2024

The disruption of a star by the tidal forces of a spinning black hole causes the stellar stream to precess, affecting the conditions for triggering the tidal disruption event (TDE). In this work, we study the effect that precession imprints on TDE light curves due to the interaction of the TDE wind and luminosity with the stream wrapped around the black hole. We perform two-dimensional radiation-hydrodynamic simulations using the moving-mesh hydrodynamic code jet with its radiation treatment module. We study the impact of black hole mass, accretion efficiency, and inclination between the orbital and spin planes. From our results, we identified two behaviours: (i) models with low-mass black holes (Mh ∼ 106 M⊙), low inclination (i ∼ 0), and low accretion efficiency (η ∼ 0.01) show light curves with a short early peak caused by the interaction of the wind with the inner edge of the stream. The line of sight has little effect on the light curve, since the stream covers a small fraction of the solid angle due to the precession occurring in the orbital plane; and (ii) models with high-mass black holes (Mh ≳ 107 M⊙), high inclination (i ∼ 90°), and high accretion efficiency (η ∼ 0.1) produce light curves with luminosity peaks that can be delayed by up to 50–100 d depending on the line of sight due to presence of the precessed stream blocking the radiation in the early phase of the event. Our results show that black hole spin and misalignment do not imprint recognizable features on the light curves but rather can add complications to their analysis.
Ecological Diversification in an Adaptive Radiation of Plants: The Role of De Novo Mutation and Introgression
Authors: Stone Benjamin W , Wessinger Carolyn A
Published: January 2024

Adaptive radiations are characterized by rapid ecological diversification and speciation events, leading to fuzzy species boundaries between ecologically differentiated species. Adaptive radiations are therefore key systems for understanding how species are formed and maintained, including the role of de novo mutations versus preexisting variation in ecological adaptation and the genome-wide consequences of hybridization events. For example, adaptive introgression, where beneficial alleles are transferred between lineages through hybridization, may fuel diversification in adaptive radiations and facilitate adaptation to new environments. In this study, we employed whole-genome resequencing data to investigate the evolutionary origin of hummingbird-pollinated flowers and to characterize genome-wide patterns of phylogenetic discordance and introgression in Penstemon subgenus Dasanthera, a small and diverse adaptive radiation of plants. We found that magenta hummingbird-adapted flowers have apparently evolved twice from ancestral blue-violet bee-pollinated flowers within this radiation. These shifts in flower color are accompanied by a variety of inactivating mutations to a key anthocyanin pathway enzyme, suggesting that independent de novo loss-of-function mutations underlie the parallel evolution of this trait. Although patterns of introgression and phylogenetic discordance were heterogenous across the genome, a strong effect of gene density suggests that, in general, natural selection opposes introgression and maintains genetic differentiation in gene-rich genomic regions. Our results highlight the importance of both de novo mutation and introgression as sources of evolutionary change and indicate a role for de novo mutation in driving parallel evolution in adaptive radiations.
Are Microstructures in Plutonic Rocks Primary or Secondary? A Re-examination of the Metasomatism Hypothesis for the Roof-Sourced Autoliths in the Skaergaard Intrusion
Authors: Holness Marian B , Andersen Jens C Ø , Namur Olivier , Nielsen Troels F D
Published: January 2024

The roof-derived autoliths in the floor cumulates of the Skaergaard Intrusion have been argued to have been extensively metasomatised and recrystallised, forming the foundation of the hypothesis that microstructures in plutonic rocks are essentially metamorphic. However, the augite–plagioclase–plagioclase dihedral angles and plagioclase core composition of the autoliths match with those of the roof rocks, demonstrating that they were generally solid on arrival at the floor, with no subsequent microstructural or compositional modification. Many autoliths have mafic rinds, which were used as evidence of metasomatism: these rinds fall into two groups. The rarely developed rind rock of Irvine et al. (1998) is most likely chilled magma infiltrating along fractures in the roof rocks, either associated directly with detachment of roof material, or occurring before final detachment. Thin mafic rims are widespread in LZc and MZ, present at the tops of the more elongate autoliths, with a corresponding felsic rim at the base of the most elongate autoliths. The close correspondence of thin rim development with autolith shape, rather than composition, is argued to be evidence that they formed as a result of differential migration of immiscible conjugate interstitial liquids: the dense Fe-rich liquid flowed downwards and ponded on the tops of impermeable autoliths, whereas its buoyant Si-rich conjugate flowed upwards and was trapped underneath. Any differences in microstructure and bulk composition of the autoliths compared with the remaining exposures of the roof sequence reflect the wider range of lithologies in the now-eroded regions of the roof.
Entropy-Area Law and Temperature of de Sitter Horizons from Modular Theory
Authors: D’Angelo Edoardo , Fröb Markus B , Galanda Stefano , Meda Paolo , Much Albert , Papadopoulos Kyriakos
Published: January 2024

We derive an entropy-area law for the future horizon of an observer in diamonds inside a static patch of de Sitter space-time, taking into account the back reaction of quantum matter fields. We prove the positivity and convexity of the relative entropy for coherent states using Tomita–Takesaki modular theory, from which the quantum null energy condition for diamonds follows. Furthermore, we show that the generalized entropy conjecture holds. Finally, we reveal that the local temperature that is measured by an observer at rest exhibits subleading quantum corrections with respect to the well known cosmological horizon temperature H/(2π).
Mild synthesis of ultra-bright carbon dots with solvatochromism for rapid lipid droplet monitoring in varied physiological processes
Authors: Su Borui , Gao Dong , Xin Nini , Wu Kai , Yang Mei , Jiang Shichao , Zhang Yusheng , Ding Jie , Wu Chengheng , Sun Jing , Wei Dan , Fan Hongsong , Guo Zhenzhen
Published: January 2024

Lipid droplets (LDs) participating in various cellular activities and are increasingly being emphasized. Fluorescence imaging provides powerful tool for dynamic tracking of LDs, however, most current LDs probes remain inconsistent performance such as low Photoluminescence Quantum Yield (PLQY), poor photostability and tedious washing procedures. Herein, a novel yellow-emissive carbon dot (OT-CD) has been synthesized conveniently with high PLQY up to 90%. Besides, OT-CD exhibits remarkable amphiphilicity and solvatochromic property with lipid–water partition coefficient higher than 2, which is much higher than most LDs probes. These characters enable OT-CD high brightness, stable and wash-free LDs probing, and feasible for in vivo imaging. Then, detailed observation of LDs morphological and polarity variation dynamically in different cellular states were recorded, including ferroptosis and other diseases processes. Furthermore, fast whole imaging of zebrafish and identified LD enrichment in injured liver indicate its further feasibility for in vivo application. In contrast to the reported studies to date, this approach provides a versatile conventional synthesis system for high-performance LDs targeting probes, combing the advantages of easy and high-yield production, as well as robust brightness and stability for long-term imaging, facilitating investigations into organelle interactions and LD-associated diseases.