bluuebunny/crossref_metadata_2025 huggingface dataset:
Transition of Intensive Care Unit Patients and Their Families to Home After Acute Hospital Care
Authors: You HyunBin , Docherty Sharron L. , Ashana Deepshikha C. , Oyesanya Tolu O.
Published: June 2024

Patients in the intensive care unit (ICU) increasingly are expected to eventually return home after acute hospital care. Yet transitional care for ICU patients and their families is often delayed until the patient is about to be transferred to another location or level of care. Transitions theory is a middle-range nursing theory that aims to provide guidance for safe and effective nursing care and research while an individual experiences a transition. Intensive care unit nurses are well positioned to provide ICU transitional care planning early. This article applies the transitions theory as a theoretical model to guide the study of the transition to home after acute hospital care for ICU patients and their families. This theory application can help ICU nurses provide holistic patient- and family-centered transitional care to achieve optimal outcomes by addressing the predischarge and postdischarge needs of patients and families.
ATP-elicited Cation Fluxes Promote Volume-regulated Anion Channel LRRC8/VRAC Transport cGAMP for Antitumor Immunity
Authors: Wang Li , Cao Limin , Li Zhihong , Shao Zhugui , Chen Xia , Huang Zhicheng , He Xiaoxiao , Zheng Junke , Liu Li , Jia Xin-Ming , Xiao Hui
Published: June 2024

The cyclic GMP-AMP synthase (cGAS)–stimulator of IFN genes (STING) pathway is instrumental to antitumor immunity, yet the underlying molecular and cellular mechanisms are complex and still unfolding. A new paradigm suggests that cancer cells’ cGAS-synthesized cGAMP can be transferred to tumor-infiltrating immune cells, eliciting STING-dependent IFN-β response for antitumor immunity. Nevertheless, how the tumor microenvironment may shape this process remains unclear. In this study, we found that extracellular ATP, an immune regulatory molecule widely present in the tumor microenvironment, can potentiate cGAMP transfer, thereby boosting the STING signaling and IFN-β response in murine macrophages and fibroblasts. Notably, genetic ablation or chemical inhibition of murine volume-regulation anion channel LRRC8/volume-regulated anion channel (VRAC), a recently identified cGAMP transporter, abolished ATP-potentiated cGAMP transfer and STING-dependent IFN-β response, revealing a crucial role of LRRC8/VRAC in the cross-talk of extracellular ATP and cGAMP. Mechanistically, ATP activation of the P2X family receptors triggered Ca2+ influx and K+ efflux, promoting reactive oxygen species production. Moreover, ATP-evoked K+ efflux alleviated the phosphorylation of VRAC’s obligate subunit LRRC8A/SWELL1 on S174. Mutagenesis studies indicated that the phosphorylation of S174 on LRRC8A could act as a checkpoint for VRAC in the steady state and a rheostat of ATP responsiveness. In an MC38-transplanted tumor model, systemically blocking CD39 and ENPP1, hydroxylases of extracellular ATP and cGAMP, respectively, elevated antitumor NK, NKT, and CD8+ T cell responses and restrained tumor growth in mice. Altogether, this study establishes a crucial role of ATP in facilitating LRRC8/VRAC transport cGAMP in the tumor microenvironment and provides new insight into harnessing cGAMP transfer for antitumor immunity.
IL DIRITTO AL CIBO PER LE PERSONE CON DISABILITÀ TRA OBBLIGHI STATALI E POLITICHE PUBBLICHE
Authors: Facchinetti Anna
Published: June 2024

The paper analyses the issue of the right to food of persons with disabilities in order to identify the policies that States should adopt to comply with their treaty obligations. To this purpose, it offers a combined reading of the International Covenant on Economic, Social and Cultural Rights (CESCR) and of the United Nations Convention on the Rights of Persons with Disabilities (CRPD). The paper argues that the dimensions of physical and economic accessibility – characterizing the right to food as interpreted by the CESCR Committee – must be read in the light of the right and general principle of accessibility for persons with disabilities enshrined in the CRPD. Member States to both treaties, such as Italy, are under the obligation to adopt all the required and appropriate measures to ensure the physical and digital accessibility not only of the food market, but also of the means to gain a living, thus granting economic access to food. States must guarantee meaningful participation to persons with disabilities, through their representative organizations, in the policy development process.
Synchronous primary parotid tuberculosis and EBV-associated primary lymphoepithelial carcinoma
Authors: Anbalagan Anandhi , Jain Deepti , Ravichander Senthil Kumar
Published: June 2024

A 48-year-old gentleman presented with complaints of neck swelling in the parotid region for 2 years. Diagnostic nasal endoscopy and video laryngeal stroboscopy were normal, and positron emission tomography scan showed no other primary lesion. The lesion with tail of parotid was excised and sent for histopathological examination. Part of the tissue was also sent for diagnosis of tuberculosis by polymerase chain reaction (PCR) as it is a very common disease in South Asian countries. At this point, differentials considered were undifferentiated primary carcinoma, metastatic undifferentiated nasopharyngeal carcinoma, and primary lymphoepithelial carcinoma. At the same time, PCR for tuberculosis came positive with rifampicin sensitive in drug resistance testing. EBV by ISH testing came out to be positive. Final diagnosis of primary lymphoepithelial carcinoma with co-existing tuberculosis of parotid was made. The patient was started on antitubercular therapy.
A re-look at the modified Ryan regression scoring system in esophageal cancer—validation of prognostic significance and comparison with other less commonly used systems
Authors: Roy Paromita , Biswal Rupanita , Honap Sayali N. , Thambudorai Robin , Bhattacharyya Tapesh , Mallick Indranil
Published: June 2024

Background:

Neoadjuvant chemoradiotherapy (NACRT) using CROSS protocol is currently the treatment of choice for esophageal cancer (EC). Tumor response grade (TRG) is a mandatory reporting criterion in most guidelines. One of the most commonly used TRG systems is the modified Ryan system. We aim to assess the TRG using modified Ryan and seven other systems (Mandard, Chireac, Swisher, Japanese esophageal society guidelines, modified rectal cancer regression grading (mRCRG), CROSS, and Becker) to evaluate their reproducibility and role as a prognostic marker.

Materials and Methods:

Two pathologists independently reviewed all cases of post-NACRT (CROSS) EC, to score TRGs and other histological parameters. Inter-rater agreement assessment for different TRG systems and correlation with disease-free survival (DFS) was performed.

Results:

Our series includes 93 patients with predominantly mid-esophageal squamous cell carcinoma. Complete pathological response (pCR) was noted in 47% (44/93) patients. The kappa inter-rater agreement score for the Ryan system was substantial (0.774), while it was almost perfect agreement for tumor percentage assessment-based systems (Swisher, CROSS, and Becker). Only the mRCRG TRGs correlated significantly with prognosis, while the Ryan system did not. Tumor stage and pCR status did not correlate with DFS, though the nodal stage was clinically significant.

Conclusion:

Though the inter-rater concordance was optimal for all the TRG systems studied, only the mRCRG system showed prognostic significance, while the commonly used modified Ryan system did not. It may be worthwhile to look at further evaluating other systems like mRCRG for inclusion in minimum dataset reporting.
Clinicopathological study of adrenal pheochromocytoma and extra-adrenal paragangliomas with reference to GAPP and PASS scoring systems
Authors: Mondal Akash , Sengupta Moumita , Dey Soumya , Kar Anish , Maiti Krishnendu , Sarkar Debansu , Chatterjee Uttara
Published: June 2024

Background:

The presence of distant metastasis is known to drastically reduce survival of adrenal pheochromocytoma (PH) and extra-adrenal paraganglioma (PGL). Therefore, predicting malignant potential has an immense impact on prognosis. Pheochtomocytoma of adrenal gland scaled score (PASS) and the grading of adrenal pheochromocytoma and paraganglioma (GAPP) score are two histological algorithms used to predict metastatic potential, but neither has been regarded as ‘gold-standard’. Both these scoring systems are yet to be validated. Here, we tried to validate the association of GAPP/PASS scores with disease outcome and strength of association between individual GAPP/PASS parameters with prognosis.

Materials and Methods:

This was a prospective study comprising 22 pheochromocytomas and eight paragangliomas. GAPP score was calculated in paraganglioma cases, and both GAPP/PASS scores were calculated for pheochromocytomas. Disease outcome was then tallied with risk stratification of the GAPP/PASS scoring system. Succinate dehydrogenase B (SDHB) immunohistochemistry was done in 15 cases to see its impact on prognosis.

Results:

The common PASS parameters associated with malignancy were ‘high cellularity’, ‘tumor cell spindling’ and ‘extension into adipose tissue’. PASS score showed high sensitivity and negative predictive value but low specificity and positive predictive value. Similarly, GAPP score also showed high sensitivity and negative predictive value but low specificity and positive predictive value.

Conclusion:

In our study, GAPP/PASS scores successfully segregated tumor with low malignant potential from tumor with higher risk of metastasis, although specificity of GAPP was more than PASS. We also found that addition of objective parameters like SDHB immunohistochemistry may further increase the specificity of the existing scoring system.
Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer
Authors: Joshi Kinjal , Shah Jigna
Published: June 2024

Aim:

The aim of study is to evaluate the crystallization pattern seen in cupric chloride medium using haemolyzed blood of control, Oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) patients.

Materials and Methods:

Study comprise 90 patients including control, OPMDs and OSCC. To create a haemolysed blood, a drop of blood was obtained and distilled water was added. Crystallization test using 0.1 ml of haemolyzed blood and 20% of a 10 ml cupric chloride solution. During 24 to 28 hours, this solution was put in a BOD incubator.

Result:

Crystallization pattern in control group is eccentric placed nucleus and peripheral radiating lines while in OPMDs and OSCC presence of transverse bar. Crystallization test showed 100% positivity in OSCC while 73.33% seen in control group. 90% sensitivity in OSCC and 76.67% sensitivity in OPMDs.

Conclusion:

OPMDs lesion convert from white to mixed red and white lesion and OSCC appear as non-healing ulcer or ulcero-proliferative growth increase in number of transverse bars. More number of transverse bars suggestive of high malignant potential.
Congenital dyserythropoietic anemia type II—A rare case report
Authors: Sharma Tejasvi , Vaswani Shruti , Barman Debasish , Didel Siyaram , Purohit Abhishek
Published: June 2024

Congenital dyserythropoietic anemia type II (CDA II), initially described as hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS), is a rare genetic disease inherited in an autosomal recessive mode that presents with mild to severe anemia. The occurrence of this entity is quite uncommon and requires extensive work-up for a conclusive diagnosis. Here, we are reporting a case of two-year-old male child who presented with severe anemia, abdominal distension, and delayed milestones. Evaluation of bone marrow aspirate suggested the possibility of CDA which led to molecular work-up by whole exome sequencing with detection of c.1142C>T (p.Thr381lle) variant in SEC23B (NM_006363.6) gene.
Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment
Authors: Wang Yi , Li Yuning , Gu Yakun , Ma Wei , Guan Yuying , Guo Mengyuan , Shao Qianqian , Ji Xunming , Liu Jia
Published: June 2024

JOURNAL/nrgr/04.03/01300535-202509000-00022/figure1/v/2024-12-31T000210Z/r/image-tiff

Poststroke cognitive impairment is a major secondary effect of ischemic stroke in many patients; however, few options are available for the early diagnosis and treatment of this condition. The aims of this study were to (1) determine the specific relationship between hypoxic and α-synuclein during the occur of poststroke cognitive impairment and (2) assess whether the serum phosphorylated α-synuclein level can be used as a biomarker for poststroke cognitive impairment. We found that the phosphorylated α-synuclein level was significantly increased and showed pathological aggregation around the cerebral infarct area in a mouse model of ischemic stroke. In addition, neuronal α-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia, suggesting that hypoxia is the underlying cause of α-synuclein-mediated pathology in the brains of mice with ischemic stroke. Serum phosphorylated α-synuclein levels in patients with ischemic stroke were significantly lower than those in healthy subjects, and were positively correlated with cognition levels in patients with ischemic stroke. Furthermore, a decrease in serum high-density lipoprotein levels in stroke patients was significantly correlated with a decrease in phosphorylated α-synuclein levels. Although ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury, some of them exhibited decreased cognitive function and reduced phosphorylated α-synuclein levels. Taken together, our results suggest that serum phosphorylated α-synuclein is a potential biomarker for poststroke cognitive impairment.
The potential mechanism and clinical application value of remote ischemic conditioning in stroke
Authors: Zhu Yajun , Li Xiaoguo , Lei Xingwei , Tang Liuyang , Wen Daochen , Zeng Bo , Zhang Xiaofeng , Huang Zichao , Guo Zongduo
Published: June 2024

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.
Electricity Consumption Classification using Various Machine Learning Models
Authors: Paikaray Bijay Kumar , Prabha Jena Swarna , Mondal Jayanta , Van Thuan Nguyen , Tung Nguyen Trong , Mallick Chandrakant
Published: June 2024

INTRODUCTION: As population has increased over successive generations, human dependency on electricity has increased to the point where it has become a norm and indispensable, and the idea of living without it has become unthinkable.OBJECTIVES: Machine learning is emerging as a fundamental method for performing tasks autonomously without human intervention. Forecasting electricity consumption is challenging due to the many factors that influence it; embracing modern technology with its heavy focus on machine learning and artificial intelligence is a potential solution.METHODS: This study employs various machine learning algorithms to forecast power usage and determine which method performs best in predicting the dataset based on different variables.RESULTS: Eight models were tested, including Linear Regression, DT Classifier, RF Classifier, KNN, DT Regression, SVM, Logistic Regression, and GNB Classifier. The Decision Tree model had the greatest accuracy of 98.3%.CONCLUSION: The Decision Tree model’s accuracy can facilitate efficient use of electricity, leading to both conservation of electricity and cost savings, and be a guiding light in future planning.
Properties of uniformly $3$-connected graphs
Authors: Göring Frank , Hofmann Tobias
Published: June 2024

A graph on at least ${{k+1}}$ vertices is uniformly $k$-connected if each
pair of its vertices is connected by $k$ and not more than $k$ independent
paths. We reinvestigate a recent constructive characterization of uniformly
$3$-connected graphs and obtain a more detailed result that relates the number
of vertices to the operations involved in constructing a respective uniformly
$3$-connected graph. Furthermore, we investigate how crossing numbers and
treewidths behave under the mentioned constructions. We demonstrate how these
results can be utilized to study the structure and properties of uniformly
$3$-connected graphs with minimum number of vertices of minimum degree.
Normal forms for quasi-elliptic Enriques surfaces and applications
Authors: Katsura Toshiyuki , Schütt Matthias
Published: June 2024

We work out normal forms for quasi-elliptic Enriques surfaces and give several applications. These include torsors and numerically trivial automorphisms, but our main application is the completion of the classification of Enriques surfaces with finite automorphism groups started by Kondo, Nikulin, Martin and Katsura-Kondo-Martin.

Comment: 32 pages; (epi)journal version
Analisis Kepuasan Publik Terhadap Angkutan Umum Model Jak Lingko Sebagai Pengintegrasi Antar Moda Transportasi Publik Di DKI Jakarta
Authors: Wijianto Wijianto , Istianto Bambang , Rukman Rukman
Published: June 2024

This study aims to analyze public satisfaction with public transportation in DKI Jakarta. As a metropolitan city as well as the capital city of the country, currently legally, it is no longer the capital of the country, but will be prepared as a global city. Jakarta residents who have reached more than 10 million people but in carrying out their mobility have not been supported by public transportation that satisfies its citizens. Although the destination of the trip has been facilitated by several modes of transportation such as MRT, commuter line and LRT which are rail and steel-based as well as Trans Jakarta and smaller land-based public transportation, it is not yet integrated. The policy of the DKI Jakarta Provincial government is to develop public transportation with a modern system called Jaklingko which functions as an intermodal integration. The operation of Jaklingko has been running for two years but has not been optimal and satisfies its users. This research method uses quantitative methods to measure how much public satisfaction with the Jaklingko. Jaklingko user satisfaction measurement is based on the theory of "service quality" from Parasuraman. The results of the study found that Jakarta residents who used Jaklingko stated that for the dimensions of the responsiveness and empathy variables the level of satisfaction reached above 80, meaning they were very satisfied with Jaklingko.
INVESTIGATION OF FLEXURAL BEHAVIOR OF CARBON FIBER BEAMS
Authors: Albayrak Mustafa
Published: June 2024

In this study, beams with hat profiles were produced. For this purpose, carbon fiber woven fabrics were preferred as reinforcement elements. Afterwards, bending test was applied to these composite beams. As a result of the experiments, displacement-force graphs were obtained on the moving cylinder. In the numerical analysis section, Hashin damage criterion was preferred for damage initiation. "Continuous Damage Mechanics (CDM)" and "Material Property Degradation (MPDG)" methods are defined in the program for damage progression. In the bending test, crushing damage was observed as the dominant damage on the surface of the specimen in contact with the moving cylinder under load. Fiber breakage along with fiber tensile damage was observed on the surfaces in contact with the fixed support rollers. It was observed that the experimental results were closer to each other with the MPDG method. The convergence rate of experimental and numerical data was determined as 89.55%.
EMPREENDEDORISMO EDUCACIONAL: UM NOVO OLHAR COM METODOLOGIAS ATIVAS
Authors: Oliveira Carlos Alexandre Firme de , Barros Carla Monique , Freire Erika Janaína Santiago Moreira , Diniz Jemima Teles Castro , Oliveira Luana Pricila Vieira , Bandeira Maria Luziene da Silva Azevedo , Cavalcante Monir Herts de Oliveira , Silva Neilton Rodrigues da , Torres Rosemeire Mafra Silva , Ramos Vívian Kelly da Trindade , Guerra Avaetê de Lunetta e Rodrigues
Published: June 2024

O estudo intitulado "Empreendedorismo educacional: uma abordagem inovadora com metodologias ativas" se baseia na ideia de acompanhar as necessidades da sociedade, levando em consideração todos os valores, conhecimentos prévios, culturais e empíricos para construir uma base de conhecimento significativa para os estudantes. O objetivo é apresentar uma experiência bem-sucedida realizada em uma escola que visa promover novas formas de aprendizado sustentável e implementar políticas educacionais que permitam aos alunos desenvolver suas habilidades de forma participativa, autônoma, alegre, inovadora, afetiva e social, interagindo com o ambiente ao seu redor. A metodologia inclui uma revisão bibliográfica e experiências práticas no campo da educação, demonstradas por meio de documentos fotográficos. Como conclusão, é possível afirmar que as contribuições filosóficas nos levam a compreender que o empreendedorismo desempenha um papel crucial na formação do indivíduo completo. Seu desenvolvimento ativo e produtivo é essencial para cultivar uma mente criativa, crítica, reflexiva, transformadora e inventiva. A oportunidade de aprender de forma interdisciplinar e tecnológica é fundamental para alcançar esse objetivo.
Analysis of didactic materials for teaching English vocabulary to Kichwa Cañari EFL students
Authors: Cazho Acero Walter Geovanny , Guamán Luna Martha Magdalena
Published: June 2024

La calidad del trabajo diario del profesor de idioma inglés depende sin duda de los materiales didácticos, que faciliten la adquisición de conceptos, destrezas y habilidades a través de la estimulación de los sentidos; por lo tanto, es importante que se ajuste a las necesidades específicas de aprendizaje de los estudiantes. La elección, preparación y aplicación de los materiales didácticos por parte del docente requieren de una planificación adecuada para lograr los propósitos del curso. El objetivo de esta investigación es analizar materiales didácticos en la enseñanza de vocabulario en inglés y cómo este puede ser aplicado con estudiantes de inglés como lengua extranjera kichwa cañari. Utilizando un método de investigación mixto, el estudio evalúa el impacto del material mediante la recopilación y análisis de datos cuantitativos y cualitativos. La parte cualitativa corresponde a la aplicación del checklist a dos escenarios de aprendizaje: con y sin material didáctico. La parte cuantitativa corresponde a la aplicación de las encuestas a estudiantes y docentes, datos que fueron expuestos a un análisis porcentual. Los hallazgos concluyen sobre la importancia del uso de materiales didácticos para la enseñanza de vocabulario en inglés porque brinda a docentes y estudiantes las herramientas necesarias para establecer un ambiente de aprendizaje dinámico, motivador e interesante, que representa una oportunidad para desarrollar experiencias de aprendizaje positivas.
Analysis Of Factors Which Affect Cafe Customer Loyalty Post Covid-19 Pandemic Using Structural Equation Modeling
Authors: Lutecia Ekacandra , Suryadi Kadarsah
Published: June 2024

One of the MSME business sectors that is most popular and frequently visited by Indonesian people is cafes. In December 2019, the global health crisis caused by the Coronavirus disease (COVID-19) began to hit, causing the world to be caught unprepared and to disrupt business activities, one of which is the cafe sector. To encourage people to visit cafes and increase revenue, further research is needed regarding factors that can increase customer purchasing power through customer loyalty. This study took data from online respondents to see their perceptions of the factors that influence customer loyalty for cafe visitors in the Greater Jakarta area. The results of distributing this questionnaire were then processed using Structural Equation Modeling (SEM). From this study it was found that customer satisfaction has the most influence on customer loyalty, which is then followed by trust and customer engagement. It was also found that service quality has a direct effect on customer loyalty. Atmosphere & environment has an indirect effect on customer loyalty. However, brand image, employee attitude, price and product quality were found to have no effect on customer loyalty.
Perlindungan Hukum Terhadap Kerugian Produsen Teksil Dalam Negeri Akibat Penyalahgunaan Surat Keterangan Asal (SKA)
Authors: Ferlyadh Ferlyadh , Sri Widiarty Wiwik , Bethlen Andrew
Published: June 2024

Perlindungan hukum memiliki makna yang sangat luas, dikatakan demikian karena perlindungan hukum dapat diberikan kepada konsumen/ nasabah/debitur, dan perlindungan hukum juga dapat diberikan kepada kreditur dan/ataupun produsen. Penelitian ini bertujuan untuk menganalisis dan mengetahui penyalahgunaan dokumen SKA serta mencari perlindungan hukum yang ideal bagi produsen dalam negeri dalam menghadapi maraknya impor tekstil dengan memanfaatkan dokumen SKA. Metode Penelitian yang akan dilakukan adalah penelitian yuridis normative. Hasil dari pembahasan kasus penyalahgunaan dokumen Surat Keterangan Asal (SKA) dalam penyelundupan tekstil dari Cina ke Indonesia melibatkan terdakwa, Drs. IRIANTO, yang merupakan Komisaris PT. FLEMINGS INDO BATAM (FIB) dan Direktur PT. PETER GARMINDO PRIMA (PGP). Mereka memanfaatkan kebijakan bea masuk dari Negara India untuk mengimpor tekstil berkualitas tinggi dengan menggunakan dokumen invoice yang dimanipulasi untuk mengurangi pembayaran bea masuk. Barang impor tersebut tidak diolah di perusahaan mereka tetapi disimpan di Petrolog Batam untuk diimpor kembali ke Jakarta dengan dokumen palsu. Tindakan ini melanggar peraturan impor tekstil dan Kepabeanan serta UU Pemberantasan Tindak Pidana Korupsi. Terdakwa juga disebut menyuap pejabat Bea Cukai Pelabuhan Batam agar tidak memeriksa kontainer impor. Akibatnya, industri tekstil dalam negeri mengalami kerugian. Proses hukum melibatkan penyidikan, penuntutan, dan pengadilan di Pengadilan Tindak Pidana Korupsi Jakarta yang menghasilkan hukuman penjara dan denda bagi terdakwa dan beberapa pejabat Bea Cukai Pelabuhan Batam. Kasus ini termasuk dalam kejahatan jabatan yang dapat menyebabkan pemberhentian sementara PNS yang terlibat.
Representation of Human in the Album "Manusia" by Tulus (Semiotic Analysis of Ferdinand De Saussure)
Authors: Sugiarti Lilian
Published: June 2024

Human life's journey, an endless exploration, unfolds continuously throughout existence. Like a flowing melody, this journey encompasses stages that depict the dynamics of human existence. This study focuses on Tulus' album 'Manusia,' an artistic creation providing a profound portrayal of diverse human experiences. Employing Ferdinand De Saussure's semiotic approach, this research delves into the symbolic meanings embedded within song lyrics. The album transcends mere melodies and words, reflecting the intricacies of humanity, ranging from love and loss to hope. A descriptive qualitative method is utilized to unveil concealed meanings behind the words. The research results illuminate how the album represents human relationships with their environment. Its lyrics depict human interaction with the surrounding world, presenting concepts of existence and reflection. 'Manusia' becomes an artistic expression capable of unraveling the inner complexities of humanity, giving voice to emotions often challenging to articulate in ordinary words.
Peran Wali Kelas dalam Mendukung Kesejahteraan Emosional Anak Kelas 1 di SD Pinangsia 03
Authors: Yusra Helsa , Darmayanti Astuti
Published: June 2024

Pendidikan merupakan faktor utama dalam melahirkan generasi yang berkualitas dan kesehatan emosional siswa berperan penting dalam mencapai prestasi akademik yang lebih baik dan penguasaan ilmu pengetahuan secara efektif. Kesehatan emosional adalah keadaan di mana siswa merasa aman, didukung, dan termotivasi untuk belajar. Penelitian ini bertujuan untuk menjelaskan peran kepala sekolah dalam mendukung kesejahteraan emosional siswa serta mengidentifikasi faktor-faktor yang menghambat dan mendukung upaya tersebut. Temuannya menunjukkan bahwa guru kelas berperan penting dalam mendorong dan menginspirasi siswa untuk belajar, mengembangkan dan mencapai potensi tertingginya. Guru kelas tidak hanya bertanggung jawab menyediakan materi pembelajaran tetapi juga berperan memberikan dukungan emosional, membangun hubungan baik dengan siswa dan membantu mereka mencapai tujuan akademik dan pribadi sebagai motivator.
Membangun Karakter Bangsa melalui Pembelajaran PKN di Sekolah Dasar: Tantangan dan Strategi
Authors: Wati Dewi Resika , Anggriani Mela
Published: June 2024

Pendidikan Kewarganegaraan (PKN) merupakan bagian penting untuk membangun karakter bangsa. PKN adalah sistem pendidikan nasional, dalam implementasinya dapat menciptakan, membangun, dan mengembangkan kemampuan, serta nilai-nilai yang terkandung di pembelajaran PKN. Hal ini berarti pendidikan mampu memfasilitasi peserta didik untuk melakukan proses belajar. Strategi pembelajaran PKN perlu disesuaikan dengan tantangan zaman yang terus berkembang. Tulisan ini membahas tentang strategi dan tantangan dalam mengembangkan karakter bangsa melalui pembelajaran PKN di sekolah dasar. Beberapa strategi efektif meliputi penggunaan pendekatan berbasis nilai-nilai lokal, penerapan pembelajaran aktif dan kolaboratif, serta integrasi teknologi dalam proses pembelajaran. Tantangan yang dihadapi antara lain kurangnya sumber daya, kesenjangan antara kurikulum dan kebutuhan aktual masyarakat, serta tantangan dalam membangun pemahaman yang mendalam tentang nilai-nilai kewarganegaraan di tengah dinamika sosial yang kompleks. Dengan memperhatikan strategi yang tepat dan mengatasi tantangan yang ada, mata pelajaran PKN yang diterapkan di sekolah dapat menjadi landasan dalam membangun karakter peserta didik yang berkualitas.
Dealing with Trauma and Restoring Well-Being
Authors:   Instructor, Social Science Unit, Tacloban City, Leyte Normal University, Bautista Prof. Dennis , D. Hugar Rose Ann ,   BSED Values Education-SV21, Matela Alisha ,   BSED Values Education-SV21, A. Miralles Erica ,   BSED Values Education-SV21, MAT Charie Ann C. Padullo ,   Research Adviser, Social Science Unit, Tacloban City, Leyte Normal University
Published: June 2024

This study examines several therapy techniques and treatments that are helpful in treating trauma and treatments that are helpful in treating trauma and increasing well-being. By conducting a thorough analysis of the body of the research, it seeks to shed light on the complex process of trauma recovery and identify the critical elements that play a pivotal role in regaining people’s general well-being. The study recommends ways that can help in dealing with traumatic experience that individuals can used as coping mechanism.
The crisis of Pakistan railways: unveiling the nexus of competence and corruption
Authors: Munawar Fareeha , Gull Maryam , Hassan Sobia , Farasat Mobina , Capraz Kursat
Published: June 2024

Pakistan Railways is facing a crisis marked by a need for more operational locomotives essential for its functioning. This study endeavours to uncover the root causes of lack of success and explore avenues for enhancing operational efficiency and effectiveness. The study draws out some parameters and resolutions about competence and corruption issues in Pakistan railways. It examines and provides possibilities for improving performance and increasing capacity by highlighting different problem areas. The well-grounded qualitative approach was used to design the research methodology. Analysis of in-depth face-to-face interviews with senior officials helped identify the significant factors of competence and corruption contributing to the decline of Pakistan railways. The study delineates key parameters and proposes resolutions to address these challenges, aiming to enhance the organisation's performance and capacity by identifying and addressing critical problem areas. The research analysis identifies the principal factors contributing to the Pakistan Railway's decline in competence and corruption. NVivo 14 was utilised to discover richer insights from the interviews, enhancing the rigour and reliability of the findings. The study offers several recommendations to concerned authorities to elevate the competence levels within Pakistan railways and steer them towards recovery and efficiency.
Expressão de marcadores tumorais CRYAB e VEGF em hemangiossarcomas caninos e sua relação com o grau histológico
Authors:   , Figueiredo Nathalia Mendes
Published: June 2024

Os sarcomas de tecidos moles (STM) são neoplasias malignas que surgem de diferentes tipos de tecido conjuntivo e células do endotélio vascular. Eles são classificados em STM de origem cutânea, subcutânea e visceral. Os STM são altamente heterogêneos, com mais de 50 subtipos histológicos distintos, e apresentam comportamentos biológicos variados. O manejo dos STM apresenta desafios significativos devido à alta taxa de mortalidade, formação de metástases, resistência à quimioterapia e recidivas após o tratamento. O diagnóstico específico dos STM é complexo devido à variedade de subtipos e à limitação das amostras disponíveis para biópsia. A imuno-histoquímica (IHQ) é uma técnica avançada na patologia que permite a identificação de alterações genéticas moleculares subjacentes aos STM por meio de marcadores específicos. A expressão de duas proteínas, CRYAB e VEGF, estão associadas à progressão tumoral e formação de metástases em vários tipos de câncer. No entanto, existem poucos estudos sobre a distribuição e influência dessas moléculas em STM e na espécie canina. O objetivo deste trabalho foi avaliar a expressão das proteínas CRYAB e VEGF em hemangiossarcomas caninos e relacionar esses achados com o grau histológico dos tumores. Para isso, foram analisadas 35 amostras de hemangiossarcomas caninos. Os fragmentos tumorais foram avaliados quanto ao grau histológico de diferenciação, necrose e taxa mitótica. Além disso, foram realizados testes imuno-histoquímicos utilizando anticorpos específicos para as proteínas VEGF e CRYAB. As lâminas foram avaliadas quanto à intensidade da marcação e quantidade de células marcadas. Conclui-se que o aumento da expressão de VEGF não está relacionado a um aumento da expressão de CRYAB em hemangiossarcomas caninos e que CRYAB não está relacionada aos fatores protetores de modulação do microambiente tumoral expressos pelos hemangiossarcomas nesta espécie. Palavras-chave: Imuno-histoquímica. Marcadores. Sarcoma. Angiogênese
Redes neurais regularizadas na predição de características agronômicas de soja
Authors:   , Costa Noé Mitterhofer Eiterer Ponce de Leon da
Published: June 2024

Um dos métodos de aprendizado de máquina utilizado atualmente na Seleção Genômica (SG) são as Redes Neurais Artificiais (RNAs) e, dentre estas, a Rede Perceptron de Múltiplas Camadas (PMC). O PMC destaca-se na solução de problemas de classificação ou regressão pelo fato de não exigir um modelo funcional, nem de atender pressuposições e não requerer conhecimento a priori sobre o fenômeno em estudo. No entanto, um problema comum nas PMC é o overfitting, que se trata de um superajustamento da rede aos dados de treinamento. Nestes casos, o modelo não possui capacidade de generalização fazendo que ele seja menos eficaz nas predições em um novo conjunto de dados ou no conjunto de teste. Para contornar este problema, algumas alternativas são as regularizações L1 e L2, que se baseiam nas regressões em penalizações similares aos métodos Lasso e Ridge, respectivamente. O objetivo deste estudo foi avaliar a eficiência do uso da regularização em modelos de PMC aplicados na predição genômica. Além disso, os resultados obtidos foram comparados com outros utilizados em predição genômica, tais como o Perceptron de Múltiplas Camadas (PMC), Árvore de Decisão (AD), Random Forest (RF), Bagging (BAG), Boosting (BOO) e Genomic Best Linear Unbiased Prediction (GBLUP). Os dados são provenientes de 100 genótipos de soja, em um experimento conduzido de setembro a novembro de 2021, no delineamento em blocos ao acaso com três repetições, em que cada parcela foi constituída de uma planta cultivada em um vaso dentro de uma casa de vegetação. Foram avaliadas as características diâmetro de hipocótilo (DH, em milímetros), altura de planta (AP, em centímetros), comprimento total de raiz (CR, em centímetros) e área superficial projetada de raiz (AR, em centímetros quadrados). Na avaliação do PMC regularizado (PMCR), foram utilizados as medidas de capacidade preditiva (CP) e raiz do erro quadrático médio (RMSE) para comparação dos métodos. Em geral, o PMC com regularização L2 melhorou o desempenho em comparação com métodos avaliados em termos de CP e RMSE. Os valores de CP obtidos pelas redes regularizadas L2 foram melhores que todos os métodos avaliados. Especificamente, quando comparado com o segundo o melhor método, os ganhos em termos de CP foram de 6,05%, 25,86%, 32,90% e 0,16% para as características, respectivamente, AP, DH, CR e AR. Já em termos de RMSE, o PMCR apresentou resultados inferiores e desejáveis em 10,81%, 15,00%, 13,62% e 20,41% para as características AP, DH, CR e AR, respectivamente, quando comparado com as redes sem regularização. Quando a comparação é entre todas as metodologias comparativas, o GBLUP obteve o menor valor de RMSE para todas características avaliadas. Palavras-chave: Capacidade Preditiva. Machine Learning. Predição Genômica.
Multi-Bit Error Resilient FPGA Cram with Minimum TTD
Authors: B. Kala  , D. Arulanantham
Published: June 2024

In harsh environments such as space, radiation and charged particles cause Single-Event and Multi-bit Effects, faults occurring randomly on any electronic component. These must be mitigated to ensure device functionality. Modern mitigation methods, such as triple modular redundancy, are very effective against Single Event Transients (SETs), but incur a minimum of 3× cost in area. Single-Event Upsets (SEUs) affect sequential elements and are regularly repaired using memory scrubbing. Scrubbing is a slow serial process, going through every memory word looking for errors to repair. It involves a non-negligible Time to Detect (TTD) before repair, during which other events can occur and compromise the system. Field Programmable Gate Arrays (FPGAs) rely heavily on sequential elements to store their configuration; thus, FPGA’s SEU detection time is critical to ensuring design integrity in harsh conditions. It is required a robust error correction code (ECC) to protect electronic devices from MCUs. The proposed work describes the conception, implementation and evaluation of new algorithm using matrix code for the detection and correction of multiple errors in FPGA configuration memories. The combined architecture with multiple bit segment with parity bits helps in locating and correcting double-triple bit errors. The proposed Method allows asynchronous MEU detection and replaces scrubbing variable time to detect with a fixed TTD. The IMECCC based on Matrix code reduces FPGA’s TTD compared to existing method.
Using Artificial Intelligence (AI) to Improve EFL Students’ Writing Skill
Authors: Losi Rizky Vita , Putra Eka Putra , Ali Nurbaiti , Dewi Adinda Silvana
Published: June 2024

When encouraged to write, students struggle to explain the idea in words. Writing skills force EFL students to use their imaginations to tell narratives or express opinions. In order to include modern technology into English language instruction, innovative approaches, materials, tools, frameworks, and procedures must be used. Digital writing tools powered by artificial intelligence (AI) have been shown through empirical studies to enhance students' written English competence. Specific technical instruments that could enhance students' writing are part of the use of AI and technology. This study used a library research methodology. Journals, books, papers, library research, theses, and proceeding journals were the sources of the information. The review claims that students may write academically in English more quickly and accurately by using a range of AI and technological tools. However, it becomes essential to integrate technology tools with the actual written skills of learners in order to effectively communicate the ideas. The purpose of tools is to assist, simplify tasks, and impart new knowledge to enable users write more academic English. In the end, by utilizing AI and technology, students can create academic English writing compositions that could help society as a whole while also developing their self-awareness, self-learning, and self-confidence.
Indicators of plasma hemostasis in hypertensive patients of different age groups
Authors: Pasko Viktoriia
Published: June 2024

Background. Scientific works of several authors determine age-related differences in hemocoagulation hemostasis. Thus, in older people, changes in hemovascular hemostasis are noted with impaired vasomotor, anticoagulant and fibrinolytic activity of the endothelium.
Anticoagulant system disorders increase with age. There are few studies on plasma hemostasis in arterial hypertension patients, especially in older age groups.
Aim: The study aimed at a complex research and comparative assessment of the plasma state hemostasis parameters in older and middle-aged hypertensive patients.
Materials and methods. 134 patients who were divided into 2 groups were examined. Group I (n = 65) – the older hypertensive patients (60 - 74 years); group II (n = 69) – the middle-aged hypertensive patients (45 - 59 years) respectively. 15 people were involved in the control for each of the studied groups (group III – the older persons and group IV – the middle-aged persons) comparable to the main in terms of age and sex. They were divided into 2 groups of 24-hour day profile of blood pressure: dippers and non-dippers. Fibrinogen (g/l) was determined on an Amelung KC 1A hemocoagulometer to assess the plasma hemostasis state. The fibrinolytic activity of plasma (min) was according to the Kowalski method, antithrombin III (%) with the help of Humalyzer Junior filter photometer.
Results. When comparing the plasma hemostasis indicators in the older and the middle-aged patients the value of antithrombin III in the middle-aged persons exceeded the similar indicator in the older persons. That is, in older patients, on the contrary, suppression of fibrinolytic and anticoagulant activity is noted. A significant slowing of the indicator of fibrinolysis activity was found in the middle-aged patients of the dipper group compared to the control group.
A significant decrease in the fibrinogen level was found in the older patients in the dipper group and its increase in the non-dipper group relative to the control. The level of the antithrombin III significantly decreased in the non-dipper group compared to normative indicators.
Conclusions. 1. The significant decrease in anticoagulant activity against the background of suppressed fibrinolysis according to indicators of the plasma hemostasis of the older patients was noted. 2. The thrombogenicity of blood plasma revealed by us during the study of plasma hemostasis indicates the high probability of thrombotic complications developing in patients.
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Keywords: arterial hypertension; essential hypertension; plasma hemostasis; fibrinogen; fibrinolytic activity of plasma; antithrombin III
Interpersonal Communication and Relationship Satisfaction in the Era of Instant Messaging
Authors: Gaston Elvis
Published: June 2024

Purpose: The general objective of this study was to examine the impact of instant messaging apps on interpersonal communication and relationship dynamics.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to instant messaging apps on interpersonal communication and relationship dynamics. Preliminary empirical review revealed that while instant messaging increased connectivity and immediacy between couples, it also led to blurred boundaries and potential stress due to expectations for immediate responses. Frequent communication via IM enhanced relationship bonds but also introduced miscommunications due to the lack of non-verbal cues. The impact varied based on individual differences and relationship contexts, with younger and long-distance couples benefiting more. The study concluded that balancing IM with face-to-face communication was essential for maintaining high relationship satisfaction.
Unique Contribution to Theory, Practice and Policy: The Social Presence Theory, Media Richness Theory and Uses and Gratification Theory may be used to anchor future studies on the impact of instant messaging on interpersonal communication. The study recommended expanding traditional communication theories to incorporate digital nuances, developing practical strategies for relationship counselors to navigate instant messaging challenges, and implementing policy changes to support healthy digital communication practices. It also suggested educational programs to enhance digital literacy, encouraged further research on demographic variations in IM use, and integrating findings into relationship intervention programs. These recommendations aimed to improve theoretical understanding, practical application, and policy development to foster healthier and more satisfying relationships in the digital era.
¡Atención, cae Centella!
Authors: Villamizar Herrera Darío
Published: June 2024

La historia de una de las operaciones militares de más importantes de su época: el ataque a Casa Verde, el campamento central de la guerrilla de las FARC, construido en la región del río Duda, en las goteras de Bogotá. Este libro narra la historia tan relevante como mítica de Casa Verde, el lugar de reuniones, visitas, acuerdos, conversaciones y planes de las FARC, que se convirtió en un enigma a los ojos de los colombianos. Después de meses de planeación, con el despliegue de medios militares no vistos hasta ese momento, el ataque se realizó el domingo 9 de diciembre de 1990, el mismo día en que los colombianos elegían a los integrantes de la Asamblea Nacional Constituyente. ¿Por qué? ¿Cómo se tomó la decisión? ¿Fue en realidad el Alto Mando Militar quien lo hizo? Este libro aborda estos y muchos otros interrogantes de manera exhaustiva y dedicada los datos y detalles, sin dejar de contar sus implicaciones políticas y las lecciones aprendidas por las Fuerzas Militares.