bluuebunny/crossref_metadata_2025 huggingface dataset:
Εμπλοκή σε καταστάσεις πένθους: Η περίπτωση του σιδηροδρομικού δυστυχήματος στα Τέμπη και ο ψυχολογικός αντίκτυπος σε Εθελοντές Διασώστες
Authors: Memet-Ali Tzan
Published: October 2024

Οι μαζικές απώλειες υγείας και οι καταστροφές που οδηγούν σε γενικευμένες καταστάσεις πένθους, επηρεάζουν όλο και περισσότερο ψυχολογικά τους πολίτες της παγκόσμιας κοινότητας. Η παρούσα έρευνα μέσω ημι-δομημένων συνεντεύξεων, πραγματεύεται, συλλέγει και αναλύει δια μέσου της Ερμηνευτικής Φαινομενολογικής Ανάλυσης, την εμπλοκή σε μαζικές καταστάσεις πένθους των Εθελοντών Σαμαρειτών-Διασωστών του Ελληνικού Ερυθρού Σταυρού, και ειδικότερα, τον βιωμένο ψυχολογικό αντίκτυπο αλλά και τη προσωπική αντιμετώπιση αυτού, κατά το σιδηροδρομικό δυστύχημα στα Τέμπη Ελλάδας, την 28η Φεβρουαρίου 2023. Καίριο ρόλο στην εν λόγω έρευνα διαδραματίζουν τα πρωτόκολλα, μοντέλα, έννοιες και θεωρίες καταστροφών, μαζικών απωλειών υγείας, διαλογής ασθενών, πρώτων βοηθειών, έρευνας και διάσωσης, αντιμετώπισης καταστροφών, ψυχολογίας, ιατρικής και παραϊατρικής. Η εκπαίδευση Διασωστών από τις Σχολές Πρώτων Βοηθειών και Διάσωσης περί θεωρητικών σταδίων πένθους, δείχνει να μην συνδέονται στενά τόσο με την ορθή προσωπική διεργασία πένθους όσο και με τη διαχείριση γενικευμένων καταστάσεων πένθους δια μέσου δυστυχήματος, μαζικών απωλειών υγείας ή/και καταστροφών, μιας και όλες οι ψυχοκοινωνικές αντιδράσεις εντάσσονται στη κατηγορία του ¨ψυχρού επαγγελματία¨. Αφενός η διατήρηση αναμενόμενης ρουτίνας και προσωπικής φροντίδας δια αποδοχής μετέπειτα του συμβάντος εναπόκειται στη προσωπική κρίση, αφετέρου η άμεση ψυχολογική ανάταση και εκ νέου εμπλοκή σε κατάσταση πένθους τοποθετείται στη συνιστώσα τόσο του κύκλου καταστροφής όσο και της εν γένει φιλοκοινωνικής νόρμας του κάθε Εθελοντή Διασώστη.
Βασικές ικανότητες στην Πρωτοβάθμια Εκπαίδευση
Authors: Μακρή Παναγιώτα
Published: October 2024

Στο πλαίσιο δημιουργίας του Ευρωπαϊκού Χώρου Εκπαίδευσης (ΕΧΕ) έχουν διατυπωθεί σύμφωνα με την Σύσταση του Ευρωπαϊκού Κοινοβουλίου οχτώ (8) βασικές ικανότητες που πρέπει να έχουν αναπτύξει όλοι όσοι ολοκληρώνουν την Υποχρεωτική Εκπαίδευση. Τα τελευταία χρόνια παρατηρείται ότι οι αυτές οι βασικές ικανότητες έχουν κατακτήσει μια σημαντική θέση στα εκπαιδευτικά συστήματα της Ευρώπης μέσα από την ενσωμάτωσή τους στα αναλυτικά Προγράμματα των ευρωπαϊκών χωρών. Σύμφωνα με την κείμενη νομοθεσία, η πρώτη βαθμίδα της Υποχρεωτικής Εκπαίδευσης στην Ελλάδα είναι η Πρωτοβάθμια Εκπαίδευση (Νηπιαγωγείο και Δημοτικό). Η συγκεκριμένη έρευνα, η οποία διεξήχθη κατά τον μήνα Μάρτιο του έτους 2024, έχει ως σκοπό να απαντήσει στο ερώτημα αν έχουν ενταχθεί οι βασικές ικανότητες στο Πρόγραμμα Σπουδών του Δημοτικού. Για την επίτευξη αυτού του στόχου, διερευνήσαμε με τη μέθοδο ανάλυσης περιεχομένου το Πρόγραμμα Σπουδών (ΔΕΠΠΣ-ΑΠΣ) του Δημοτικού. Σύμφωνα με τα βασικά ευρήματα της έρευνάς μας φαίνεται ότι οι βασικές ικανότητες, οι οποίες συνδέονται με τα μαθησιακά αποτελέσματα του ΕΧΕ, έχουν ενταχθεί στο Πρόγραμμα Σπουδών του Δημοτικού.
Η Δημογραφική Κατάσταση και η Πρωτοβάθμια Εκπαίδευση στην πόλη της Κατερίνης από το 1912-1930
Authors: Καλλέργης Στέργιος
Published: October 2024

Η πρωτοβάθμια εκπαίδευση στην πόλη της Κατερίνης από την ενσωμάτωση της το 1912 μέχρι και τις αρχές του 1930 αποτέλεσε μια περίοδο σημαντικής ανάπτυξης και μετασχηματισμού, αντικατοπτρίζοντας τις ευρύτερες αλλαγές στην ελληνική κοινωνία και το εκπαιδευτικό σύστημα. Μετά την απελευθέρωση της Κατερίνης από την Οθωμανική Αυτοκρατορία το 1912 και την ενσωμάτωση της στον ελληνικό κορμό, η πόλη άρχισε να αναπτύσσεται οικονομικά και πληθυσμιακά. Η ανάγκη για εκπαίδευση έγινε πιο επιτακτική, καθώς οι νέες συνθήκες απαιτούσαν μια πιο μορφωμένη κοινωνία. Κατά τη δεκαετία του 1910 και του 1920, ιδρύθηκαν νέα σχολεία και βελτιώθηκαν οι υφιστάμενες εκπαιδευτικές υποδομές. Οι σχολικές αίθουσες επεκτάθηκαν και εξοπλίστηκαν καλύτερα για να ανταποκριθούν στις ανάγκες των μαθητών. Σημαντικό ρόλο έπαιξε η τοπική κοινότητα και οι εθνικές προσπάθειες για τη βελτίωση των συνθηκών εκπαίδευσης. Συνολικά, η περίοδος από το 1912 μέχρι τις αρχές του 1930 ήταν μια εποχή μεταβατική αλλά και δημιουργική για την πρωτοβάθμια εκπαίδευση στην Κατερίνη. Οι θεμελιώδεις αλλαγές και οι προσπάθειες για βελτίωση άφησαν ένα ισχυρό αποτύπωμα που συνέβαλε στην μετέπειτα ανάπτυξη της εκπαιδευτικής υποδομής και της κοινωνίας της πόλης, γι’ αυτό σκοπός της παρούσης εργασίας είναι η ανάδειξη τόσο της πρωτοβάθμιας εκπαίδευσης εντός της πόλης της Κατερίνης, όσο και η δημογραφική εξέλιξη από το 1912 μέχρι το 1930.
Dusky grouper massive die-off in a Mediterranean marine reserve
Authors: KERSTING DIEGO K. , GARCÍA-QUINTANILLA CELIA , QUINTANO NAGORE , ESTENSORO ITZIAR , ORTEGA-VILLAIZAN MARÍA DEL MAR
Published: October 2024

The dusky grouper Epinephelus marginatus (Lowe, 1834) is a key predator in shallow Mediterranean rocky habitats. Due to fishing pressure and slow population dynamics, dusky grouper populations are declining across their distribution range. Here we document a massive die-off of E. marginatus in the Columbretes Islands Marine Reserve (NW Mediterranean Sea) during the summer and early autumn of 2023. The mortality event was triggered by a Betanodavirus infection. Genetic characterization of isolates from the affected fish confirmed that they belong to the RGNNV genotype. Our findings indicate that such disease outbreaks can be particularly severe in areas with dense dusky grouper populations, potentially undermining the historical conservation effectiveness of marine protected areas. Although our results do not determine whether the infection originated from wild or farmed fish, it is essential to implement monitoring and early detection systems for Betanodavirus infections in both wild and farmed fish to prevent cross-infections.
Powieść jako mozaika gatunków
Authors: Skubaczewska-Pniewska Anna , Korwin-Piotrowska Dorota
Published: October 2024

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Powieść nowelowa – przypadek Elizabeth Strout
Authors: Izdebska Agnieszka
Published: October 2024

Termin „powieść nowelowa” (przyjęty za Krystyną Jakowską, a definiowany za Elke D’hoker) odnosi się do dzieł literackich, które genologicznie lokują się pomiędzy bardzo spójnie skomponowanym zbiorem opowiadań a luźną konstrukcją powieściową. W tym tekście rozważam sensowność posługiwania się tym terminem i cechy konwencji, do której odsyła. Powołuję się na rozliczne przykłady dzieł dających się klasyfikować jako powieści nowelowe właśnie. Odsyłam zatem czytelnika, na przykład, do dwu tekstów Alice Munro – Dziewczęta i kobiety oraz Za kogo ty się uważasz? – polskich dzieł Magdaleny Tulli (Włoskie szpilki i Szum) i Wioletty Grzegorzewskiej Guguły i Stancje. Zasadniczym przedmiotem tego tekstu jest jednak analiza dwóch powieści Elizabeth Strout jako modelowych przykładów omawianej formy narracyjnej. Pierwszy z tekstów to Olive Kitteridge, następny to kontynuacja fabularna pierwszej opowieści, zatytułowana Olive powraca. W artykule pokazane są mechanizmy uspójniające oba teksty składające się z samodzielnych opowiadań oraz funkcja, jaką pełni forma powieści nowelowej w specyficznie przez Strout skonstruowanej wersji powieści inicjacyjnej, a nawet przewrotnie użytej konwencji Bildungsroman. Przedstawiona też jest wymuszana konstrukcją powieści nowelowej strategia lektury obu tekstów.
Jedno zdanie Gabriela Garcíi Márqueza
Authors: Przybyslawski Artur
Published: October 2024

Tekst jest analizą pierwszego zdania powieści Sto lat samotności Gabriela Garcíi Márqueza. Zadaniem tej analizy, która jest inspirowana metodą Rolanda Barthes’a przedstawioną w książce S/Z, jest rekonstrukcja literackiej genealogii tego wypowiedzenia, zdanie sprawy z jego niezwykłego bogactwa treści oraz ukazanie jego sposobu traktowania czasu powieściowego. Zdanie podzielone zostaje na mikroleksje, które następnie badane są jako oddzielne jednostki. Drobiazgowa analiza ukazuje ich uwikłanie w szereg literackich kontekstów, które zwykle umykały w dotychczasowych badaniach. Rozważenie tego zdania w perspektywie narracji całej powieści ze szczególnym uwzględnieniem jego zakończenia pokazuje również szczególne podejście pisarza do fikcji literackiej i jej relacji do czytelnika. ten sposób studium to próbuje odpowiedzieć na pytanie, dlaczego zdanie to uznawane jest za jedno z najgenialniejszych zdań literatury współczesnej. Artykuł jest fragmentem większej całości, jaką jest planowana monografia analizująca pierwsze zdania wielkich powieści literatury zachodniej.
Raquitismo Hipofosfatemico Ligado al Cromosoma X a propósito de un caso
Authors: Baquero Rodriguez Richard , Tascón Arcila Jose Andres , Serrano Gayubo Ana Katherina , Baquero Rodriguez Maria Carmen
Published: October 2024

Introducción: el raquitismo se caracteriza por una alteración en la mineralización normal del tejido óseo, clasificándose según la causa en formas adquiridas o hereditarias. De los raquitismos hereditarios, el raquitismo hipofosfatémico ligado al cromosoma X es el más común. Se caracteriza por anomalías en el metabolismo del fósforo, secundario a una alteración en el gen PHEX (phosphate regulating endopeptidase analog, X-linked) ubicado en el cromosoma X. Como resultado de esta alteración se afecta la codificación de una metaloproteasa que tiene como función disminuir los niveles séricos del factor de crecimiento fibroblástico - 23 (FGF-23), que resulta en la perdida anormal de fósforo por orina. Clínicamente se presenta con deformidades óseas en miembros inferiores, dolor óseo, talla baja y alteraciones dentales. El diagnóstico es clínico, asociado a hipofosfatemia, fosfaturia y hallazgos radiológicos de raquitismo, confirmándose con la prueba molecular de la mutación del gen PHEX. Presentación del caso: Se describe el caso de una paciente de 5 años de edad a quien se le hace diagnóstico de esta enfermedad, lo que permitió el inicio de un tratamiento oportuno y un abordaje integral. Conclusión: por tratarse de una enfermedad hereditaria poco común, con debut en la infancia y gran impacto en el crecimiento longitudinal y salud ósea que afecta la calidad de vida de los niños, el conocimiento de este caso tiene como objetivo brindar herramientas básicas para un abordaje que lleve a un diagnóstico temprano, dado que esto es clave para el pronóstico, seguimiento y tratamiento multidisciplinario de esta patología.
Nursing students and clinical nurses’ perception of research and the role of the clinical research nurse
Authors: Cetroni Amanda
Published: October 2024

Background:

The nursing profession has made great strides during the last century. Roles such as the clinical research nurse (CRN) have been developed and research is widely recognised as a vital component of the healthcare field. Hospitals involved in clinical nursing research can improve patient outcomes, increase staff and patient satisfaction and reduce hospital costs.

Aim:

The aim of this literature review is to analyse nurses and nursing students’ perception towards research, with focus on the available career progression for nurses in research.

Method:

A comprehensive search of literature on ASSIA, CINAHIL, PubMed and Web of Science electronic databases was conducted to obtain relevant articles related to the perception of nurses and nursing students towards research.

Results:

A total of 31 articles were selected for analysis following review. Three key themes were identified: nurses’ perception towards research; nursing students’ perception towards research; and career progression and job satisfaction.

Conclusions:

Involvement in research has helped nurses integrate evidence-based practice into their work. This has helped empower nurses to make positive change and develop their skills and knowledge. Unfortunately, research is still considered by many to be a ‘doctor’ field, and nurses have various difficulties accessing funding and education. Research education is vital to building the basic principles of nursing research and creating a positive attitude and perception around research. A change in culture is required to standardise research into university education, increase students’ perceptions and confidence in research, and help nurses incorporate valid evidence-based recommendations into practice.
Structural Variance of Doxorubicin and Anthracycline Analogues as Topoisomerase Alpha and Beta (Top2a and Top2b) Inhibitors. Potential Design of Analogue Candidates of Less Side Effects on Cardiomyocytes.
Authors: El-Shorbagi Abdel-Nasser , Chaudhary Sachin , Kumar Hitesh , Verma Harish Chandra , Tripathi Prabhash Nath , Giri Aditi , Agarwal Garima , Dumoga Shweta , Gupta Ramesh Kumar
Published: October 2024

Doxorubicin that is on WHO's list of essential medicines and other anthracycline analogues, in general, are natural metabolites isolated from Streptomycetaceae, or semi-synthetized derivatives stated as first-generation anticancer agents. The tetracyclic scaffold attached mostly to amino sugar is known to be effective against solid tumors compared to other anticancer agents. The mechanism had been stated as intercalating agent at the minor groove of DNA strands during the step of releasing supercoiled DNA. Along with their anticancer activity, anthracyclines possess antimicrobial effects of notable MIC values. Cardiotoxicity represents the main challenge for both of medical care for treatment of cancers and drug discoverers. This exertion deals with careful structural investigation of the three-dimensional, fully optimized drugs in use. Drug-candidates in clinical studies, and leads failed in last developments. The aim is to find a structural gate to guard against or reduce the cardiac side effects. It deals also, with the topological features differentiating between antibacterial and anticancer agents bearing the tetracyclic scaffold features as well as between the topoisomerases as target molecules.
Advancement of Nanofibers in Wound Healing: A Review
Authors: Kotteeswaran Venkatesan , Saravanakumar Mrinalini , Alexander Roshelle Mary , Nair Radhika S , Ramnath Kavin M
Published: October 2024

The field of wound healing is currently experiencing a ground-breaking transformation with the introduction of nanofiber technology. This groundbreaking discovery has the potential to revolutionize regenerative medicine and tissue engineering worldwide, effectively meeting the growing need for innovative and affordable healthcare solutions. This comprehensive review explores the evolution and utilization of nanofibers to enhance wound healing. Nanofibers, known for their ability to mimic the extracellular matrix of human tissue, play a crucial role in facilitating cell growth and wound repair. The review explores sophisticated techniques like electrospinning and the integration of bioactive agents such as antibiotics and growth factors with nanofibers. It emphasizes on the precision with which these nanofibers are customized to address specific therapeutic requirements. Additionally, the review sheds light on the use of both natural and synthetic polymers in crafting biocompatible nanofibers, which significantly reduces healing time while ensuring optimal aesthetic recovery, meeting the expectations of patients with minimal scarring. It emphasizes the synergy of expertise from materials science, biology,and clinical practices in propelling nanofiber-based therapies from the laboratory to the forefront of clinical care. Through this succinct overview, we aim to underscore the immense potential of nanofibers in transforming wound care. We are offering a glimpse into a future where effective and efficient healing is within reach, marking a remarkable leap forward in the global quest for advanced healthcare solutions.
Phthalate Exposure and Pediatric Asthma: A Case Control Study Among Egyptian Children
Authors: El Refay Amira S. , Armaneous Ayman F. , Salah Dina A. , Youssef Mai , Salah Ebtissam , Shady Mones Abu , Baroudy Nevien R. El , Morsy Safaa , Gouda Amr , Nazem Walaa S.
Published: October 2024

Background: Phthalates, which are diesters of phthalic acid, are commonly used as plasticizers and additives in various consumer products. Several phthalates have been identified as substances of high concern. Exposure to phthalate esters (PAEs) has been linked to asthma in children, but the specific impacts of PAEs on asthmatic children were not well understood. Objective: The objective of this study was to compare urinary phthalate concentrations in asthmatic and non-asthmatic children and to identify potential sources of exposure as risk factors for asthma. Methods: A case control study was conducted for 100 Egyptian children aged 8-16 years (50 asthmatics and 50 healthy controls). Asthma was identified using GINA guidelines. Socio-demographic and probable risk factors were assessed, in addition to measuring phthalate levels in urine samples using high-performance liquid chromatography. Results and conclusion: Mean urinary Mono-methyl as well as Mono-benzyl levels were highly significant in asthmatic children compared to control group (895.26ng/ mL vs 548.55 ng/mL and 13.5 ng/mL vs 2.07 ng/mL respectively) (p= 0.001). The number of asthmatic children living in houses painted with non-plastic paint was significantly lower (P<0.05) than children living in houses painted with other paints. No association between floor type and asthma was reported. The frequent use of personal care products and plastic painting of walls were identified by multiple logistic regression analysis as the highly significant predictors of asthma in the studied subjects. The declared higher levels of urinary phthalate metabolites (Mono-methyl and Mono-benzyl) in Egyptian asthmatic children may reveal the probable risk of phthalate exposure in triggering bronchial asthma.
Extract of Angelica keiskei Leaves Attenuates Spatial Memory Impairment on the D-galactose Model of Brain Aging in Mice
Authors: Siswanto Ferbian Milas , Wijaya Indah Mira Tiaraputri , Handayani Maria Dara Novi , Dewi Rita , Ekowati Ana Lucia , Manalu Jojor Lamsihar , Novelya Novelya
Published: October 2024

Aging is a complex and inexorable phenomenon, entailing several physiological changes. Impaired memory skills are associated with cell death in the hippocampus as a result of the age-related buildup of free radicals. D-galactose can artificially accelerate brain aging, causing memory impairment in mice due to neuroinflammation and oxidative stress. Numerous phytoconstituents found in Angelica keiskei possess anti-oxidant, anti-inflammatory, and memory-enhancing properties. In this study, we sought to determine the effects of an ethanol extract from the leaves of A. keiskei (EELAK) on spatial memory in mice with impaired memory functions due to D-gal. Here, we showed that administering 300 mg/kg BW/day of D-gal orally for a duration of 28 days significantly decreased spatial memory as quantified by the Morris Water Maze, and this was linked to a marked increase in hippocampal acetylcholinesterase (AChE), inflammation, and oxidative stress. The spatial memory of D-gal-induced mice was markedly enhanced by 20 mg/kg BW/day of EELAK, demonstrating its potent memory-boosting properties. The mice treated with EELAK also showed a notable decrease in hippocampal neuroinflammation (p65 NF-kB, NO, and TNF-α protein) and an increase in antioxidant activity (elevated SOD activity and reduced MDA levels), suggesting its potent neuroprotective activity. In conclusion, our results establish for the first time that by reducing oxidative stress and neuroinflammation, EELAK enhances spatial memory. Hence, for the prevention and treatment of age-related neurodegenerative illnesses like Alzheimer's disease, EELAK may be a useful therapeutic approach.
The Effect of Keluwih (Artocarpus camansi) Leaves Extract On Pro-Inflammatory Expression, Growth Factors and Bodies in Zebrafish Larvae (Danio rerio) Stunting Model
Authors: Gondokesumo Marisca Evalina , Muslikh Faisal Akhmal
Published: October 2024

Stunting is a chronic nutritional problem that occurs during the first 1000 days of life which is considered a golden window of opportunity. Indonesia has the highest prevalence compared to other middle-income countries. Keluwih (Artocarpus camansi) is known to have various compounds that are beneficial for the body such as anti-inflammatory and antioxidant. This study was conducted to determine the potential of the ethanol extract of Keluwih leaves (Artocarpus camansi) zebrafish stunting model against inflammatory markers, growth factors and body size. Artocarpus camansi leaves were extracted using the maceration method for 3x24 hours with 96% ethanol solvent. Zebrafish larvae were obtained from male and female broodstock (2:1), then induced using rotenone and ethanol extract of Artocarpus camansi leaves, then immunohistochemical staining was performed using growh factor (VEGF and TGF-β), inflammation (IL-6 and TNF-α) and body length measurements on day 9 dpf. The results showed that rotenone can provide a picture of stunting in zebrafish larvae from observations of growth factors, inflammation and body length, by administering ethanol extract of Artocarpus camansi leaves this can improve stunting conditions due to administration of rotenone, the concentration of ethanol extract of Artocarpus camansi leaves 2.5 ppm is the optimal concentration in improve stunting conditions. The ethanol extract of Artocarpus camansi leaves can improve stunting conditions by increasing the expression of growth factors, decreasing pro-inflammatory cytokines and improving body length in zebrafish larvae.
Enhancing Skin Disease Diagnosis with TFFNet: A Two-Stream Feature Fusion Network Integrating CNNs and Self Attention Block
Authors: Gairola Ajay Krishan , Kumar Vidit , Sahoo Ashok Kumar
Published: October 2024

The skin of an individual serves as the primary defense mechanism for safe guarding vital organs in the body. Although this barrier effectively protects internal organs from a variety of threats, it is still prone to damage from viral, fungal, or dust-related illnesses. Even minor skin injuries possess the potential to escalate into more severe and hazardous conditions. A prompt and precise skin disease diagnosis becomes crucial in expediting the healing process for individuals grappling with skin-related issues. The objective of this study is to develop a system based on Convolutional Neural Network (CNN) that can accurately identify various skin diseases. The proposed architecture, known as TFFNet (Two-Stream Feature Fusion Network), integrates two simultaneous modules featuring a Self-Attention (SA) block. We employ Self Attention-Convolutional Neural Networks (SACNNs) and Depthwise Separable Convolution (DWSC) to establish a diagnostic system for skin diseases. In this method, two separate CNN models are joined together, and two parallel modules (M1 and M2) are added. This greatly reduces the total number of trainable parameters. In comparison to other deep learning methods outlined in existing literature, the proposed CNN exhibits a notably lower number of learned parameters, specifically around 7 million for classification purposes. The skin disease classification was carried out on three datasets—ISIC2016, ISIC2017, and HAM10000. The model achieved testing accuracies of 89.70%, 90.52%, and 90.12% on each respective dataset.
Effect of Metformin on Interleukin-6 Expression in Human Fibroblast Cell Aging Model
Authors: Achadiyani Achadiyani , Prabhasiwi Denata , Pratiwi Auria Ekanti , Hamudin Aceng , Heryaman Henhen , Alfarafisa Nayla Majeda , Atik Nur
Published: October 2024

During skin aging, there is excessive secretion of inflammatory cytokines such as interleukin-6 (IL-6), which can make the ageing process more severe. Metformin has been known to have good anti-inflammatory activity through various pathways, one of which reduces the expression of inflammatory cytokines. This study aimed to analyze the effect of metformin treatment on IL-6 gene expression in an in vitro human fibroblast cell. Human fibroblast cells were obtained through foreskin isolation, and 72 cultured human fibroblast cells were divided into six groups based on cell passages, ranging from the third to the eighth. The expression of IL-6 was assessed in three treatments: negative control (normal cells), metformin 100 µM, and positive control (Vitamin E 50 µM). Treatment and measurement of IL-6 gene expression were carried out using qRT-PCR and calculated using the Livak-Schmittgen method. The results were then compared and analyzed using One-Way Analysis of Variance (ANOVA) and followed by post-hoc analysis. The negative control group had the lowest IL-6 gene expression compared to the metformin group and positive control group. The negative control IL-6 expression showed the highest value at passage 3 (0.166 ± 0.04) and the lowest at passage 6 (0.048 ± 0.04). Meanwhile, the expression of IL-6 positive control passage 4 (5.590 ± 3.34) showed the highest value and passage 7 (0.000 ± 0.00) showed the lowest value. In the metformin group, IL-6 gene expression was highest in passage 5 (0.836 ± 0.15) and lowest in passage 3 (0.078 ± 0.02). Based on treatment, there is a difference in IL-6 gene expression at passage 4 (p-value <0.05) and passage 5 (p-value <0.001). Metformin treatment passage 5 showed a significant difference with negative control (p-value <0.05) and with positive control (p-value <0.05). Our study concluded that the administration of metformin had no effect on IL-6 gene expression in human fibroblasts. However, metformin demonstrated anti-aging potential, as evidenced by a statistically significant difference in IL-6 expression between the negative control and positive control treatment groups.
Chronic Kidney Disease Detection Using Machine Learning: From Analysis to Framework Development
Authors: Kaur Bobbinpreet , Goyal Bhawna , Dogra Ayush , Ramshankar Sonam , Singh Devendra , Alkhayyat Ahmed
Published: October 2024

Considering the aspects of sustainable development goals, Good health and well-being ensure the development of a nation. Chronic kidney disease (CKD) is a progressive and irreversible condition characterized by the gradual loss of kidney function over time. One of the major diseases, CKD affecting 10-15% population globally needs to be detected at early stages to reduce morbidities and mortalities. Majorly the risk factors include Diabetes, Hypertension, Age, Hereditary, and Ethnicity which need to be screened on regular intervals to ensure the timely detection of the disease. The primary hurdle for detection is asymptomatic behavior during the early stages. Machine learning (ML) based models are majorly governing various sectors and applications. The models have capabilities to serve as assistance to the medical practitioners for effective CKD detection at early stages. This paper demonstrates the development of a framework for early detection considering various parameters.
In-silico Molecular Docking of Two Bioactive Constituents (Quercetin 3-Glucuronide and Quercitrin) from Polygonum minus Leaves into Monoamine Oxidase-A Crystal Structure
Authors: Bashir Muhammad Irfan , Aziz Nur Hidayah Kaz Abdul , Noor Dzul Azri Mohamed , Ibrahim Umar Idris , Zahari Zalina
Published: October 2024

The aim of the current research was to dock the two abundant bioactive constituents of Polygonum minus leaf extract, in1cluding Quercetin 3-Glucuronide (Miquelianin) and Quercitrin (Quercetin-3-rhamnoside). In-silico Molecular modelling technique was used to predict about a protein (enzyme) interacts with molecules (ligands). Monoamine oxidase-A (MAO-A) is the key enzyme that is involved in the breakdown of neurotransmitters like serotonin and noradrenaline. Drugs that are involved in its inhibition, are considered to be antidepressant agents. This molecular docking study observed the binding energy of selected ligands and their interactions with amino acid residue along with bond types in the MAO-A structure. Molecular docking was done using Molecular Operating Environment (MOE) software, whereas visualization and expression of results were carried out using Discovery Studio (DS) visualizer. Clorgyline was used in this study as a co-crystal ligand, whereas moclobemide was used as a standard MAO-A inhibitor, and Amitriptyline was used as a common antidepressant which also has some MAO-A inhibitory effect. Quercetin 3-glucuronide (Miquelianin) and Quercitrin (Quercetin-3-rhamnoside) have more binding affinities with MAO-A structure as compared to all other drugs. Its interaction pattern was most likely moclobemide and Clorgyline, which are considered standard MAO-A inhibitors in this study. Based on these results, it is concluded that Quercetin 3-Glucuronide (Miquelianin) and Quercitrin (Quercetin-3-rhamnoside) have the potential to become potent MAO-A inhibitors in future.
The Establishment of the Spiking Method to Evaluate the Rapid Diagnostic Test Antigen (Ag-RDT) Product for COVID-19 Detection
Authors: Wiraswati Hesti Lina , Faridah Lia , Ekawardhani Savira , Hidayati Nur Akmalia , Fidausi Anastasya , Nurjannah Neng Rita , Laelalugina Amila , Fauziah Nisa
Published: October 2024

The quality control of the COVID-19 Rapid Diagnostic Test (Ag-RDT) product is regarded as one of the government’s responsibilities. The Indonesian government establishes rules for Ag-RDT post-market validation, where it should be performed by two designated laboratories, using the spiking technique. The usage of this technique raises concerns, especially if it does not represent the precise product quality, due to the sample dilution. In addition, the requisite of using fresh samples that should be prepared for less than 48 hours is considered costly and time-consuming. In response to this, we tested two samples from different age groups on the Ag-RDT brand recommended by the World Health Organization (WHO); Panbio™ Covid-19 Ag Rapid Test (Abbott) and standard Q Ag-RDT (SD Biosensor, Roche). In both Ag-RDT products, the samples observed in the cycle threshold (Ct) values≤25 groups exhibit >80%sensitivity and >97% specificity as in compliance with the WHO recommendation. Meanwhile, as observed in the Ct>25 groups, the sensitivity of the two Ag-RDT products was below 25%, which was not in compliance with the WHO recommendation. Overall, this study indicated that the Spiking technique is eligible to be used for evaluating the performance of Ag-RDT, especially at Ct≤25. Additionally, the samples’ life span of up to 2 weeks of storage at -80oC can be used for post-market validation of Ag-RDT. Furthermore, the quality control assay for longer sample storage is interesting to be carried out.
Influence of Kidney Diseases on Lipid Profile in Patients Undergoing Conservative Managements and Hemodialysis
Authors: Salah Minwer , Almajali Belal , Alfawaeir Saad , Ahmed Khaled A. , alsayed Osama , Al-Jamal Hamid Ali Nagi
Published: October 2024

Kidney function gradually declines as a result of chronic kidney disease (CKD). The current study was conducted at Princess Iman Hospital in Muadi, Jordan from December to March 2024. It aimed to investigate the association between lipids and chronic renal failure (CRF), which refers to the advanced stages of CKD where kidney function has declined significantly, and to understand how dyslipidemia affects the development of CKD and general health outcomes. The study involved three groups of participants: patients with CRF who were on hemodialysis, those receiving conservative management for CRF, and healthy individuals as controls. According to the findings, CRF patients (hemodialysis and conservative management) had significantly higher lipid levels than the control group besides showing low indicators for kidney function (p<0.001). In addition, triglyceride, cholesterol, low-density lipoprotein (LDL) levels, Cholesterol/high-density lipoprotein (HDL) ratio, and LDL/HDL ratio were also found to be significantly high in the hemodialysis group when compared to the conservative group (p<0.001). In this population with CRFs, it was observed that lipid levels correlated positively with markers for kidney disease progression. Therefore, monitoring of lipids should be done regularly across all stages of CKDs to reduce cardiovascular complications associated with atherosclerosis. Hence, incorporating lipid evaluations into standard CKD care regimens, even during the initial phases, is vital for enhancing patient outcomes and lowering mortality risks. In essence, the results highlight the importance of proactive management of lipid levels in CKD individuals to tackle cardiovascular complications effectively. By understanding dyslipidemia's impact on CKD advancement, healthcare practitioners can customize interventions to enhance patient care and diminish related risks, ultimately improving prognosis and decreasing mortality rates among CKD cohorts.
Ultra-efficient surface grating couplers for chip-to-fiber and chip-to-free-space coupling based on single-beam radiation
Authors: Sánchez-Postigo Alejandro , Ginel Pablo , Schmid Jens , Hadij-ElHouati Abdelfettah , Ortega-Moñux Alejandro , Wangüemert-Pérez J. Gonzalo , Halir Robert , Cheben Pavel , Molina-Fernandez Inigo
Published: October 2024

Surface grating couplers, such as fiber-chip grating couplers and optical antennas, are fundamental devices in photonic integrated circuits, as they enable the coupling of light between the chip and an external medium. An important metric of surface grating couplers is the coupling efficiency, and high values, greater than -1 dB, are required for applications in quantum technology, light detection and ranging, and optical interconnects. Surface grating couplers typically suffer from radiation loss to the substrate, which significantly limits their coupling efficiency. Here we propose a novel grating-coupling concept that utilizes a high-refractive-index upper cladding to frustrate radiation orders to the substrate by operating in a single-beam diffraction regime. To illustrate this concept, we report the design of an easily fabricable silicon surface grating coupler with an unprecedented coupling efficiency of -0.2 dB to a single-mode optical fiber. Furthermore, the proposed strategy allows us to design an evanescently coupled millimeter-long optical antenna with a coupling efficiency of -0.1 dB to free space. Additionally, an ultra-fast wavelength-tunable beam steering of 0.37 degree/nm is achieved, which corresponds to more than a 2.5-fold enhancement over comparable silicon antennas. These results represent a pathway for a new set of photonic integrated interfaces for applications in which high-efficiency chip-to-fiber and chip-to-free-space coupling is critical.
Investigation of Kerr nonlinearity in multi-layered silicon nitride waveguides
Authors: Permana Dharma P. , Klaver Yvan , Marpaung David , Iskandar Alexander
Published: October 2024

Silicon nitride is a promising waveguide platform for harnessing Kerr nonlinearity due to the low propagation loss, wide transparency range, and negligible two-photon absorption effect in the telecom wavelength range. However, the values of Kerr nonlinear coefficient of various low loss silicon nitride waveguide structures are not well defined. In this work, we perform numerical and experimental investigations of Kerr nonlinearity coefficients of multi-layered silicon nitride (Si3N4) waveguides. Three distinct geometries were considered, namely asymmetric double stripe (ADS), symmetric double stripe (SDS), and thick Si3N4 waveguides. The numerical investigation was done using three different models: scalar, vectorial, and perturbative models. The Experimental investigations were carried out using four-wave mixing experiments. We found good agreement between the theoretical and experimental results, leading to silicon nitride Kerr index of 1.644 × 10−19 W−1m2.
Barriers and enablers that influence the uptake of HIV testing among heterosexual migrants in the Netherlands
Authors: Martinez Martinez Veronica , Ormel Hermen , Op de Coul Eline L. M.
Published: October 2024

Background

Heterosexual migrant men and women in the Netherlands often face barriers to accessing health services, including HIV testing, that may lead to late-stage HIV diagnoses. This study explored factors of influence in the usage of HIV testing among heterosexual migrants.

Methods

Qualitative evaluation with semi-structured interviews at the Amsterdam-based AIDS Healthcare Foundation (AHF) Checkpoint and one focus group discussion (FGD) conducted during June-July 2023 with 19 participants: interviews with 12 heterosexual migrants from low- or middle-income countries (LMICs) and FGD (n = 5) and interviews (n = 2) with 7 key informants from the (public) health sector. Recorded interviews were transcribed and thematically analyzed, using the framework of Andersen’s Expanded Behavioral Model of Health Services Use.

Results

In total, 55 themes emerged from the interviews and the FGD. Examples include insufficient availability of information on HIV and testing services, and difficulty in accessing these services (e.g. the barrier of the online appointment system of the Centre for Sexual Health (CSH)). HIV test participants expressed free, rapid testing, no appointment required, and a positive experience during their HIV test as enablers to test in the future. Results from key informants showed that poor health literacy and lack of clarity on the healthcare system’s guidelines were barriers for heterosexual migrants in accessing information on HIV and testing services. It also revealed past initiatives and interventions that were successful in reaching at-risk groups such as the integration of HIV testing into sexually transmitted infection (STI) testing, but that were subsequently discontinued due to financial constraints.

Conclusion

Factors contributing to a low HIV test uptake were participants’ perception of limited accessibility of CSH facilities, insufficient available information on HIV (testing) services, and low perception of HIV risk. Unclear policies on accessing HIV/STI testing services at CSHs, and potential missed opportunities for HIV testing at general practitioners were contributing factors identified by key informants.
Evaluation navigation controlled gate of aging spillway on cavitation damage
Authors: Hien Le Thi Thu , Chien Nguyen Van , Duc Nguyen Viet
Published: October 2024

Background

High-speed flow of clean water or water with sediment released from aging spillways may cause abrasion and cavitation on the concrete surface gradually. The occurrence of irregularities on the concrete surface can exacerbate the erosion problem. Which might jeopardize the safety of dams constantly, hence the rehabilitation efforts become urgent tasks in dam safety projects.

Methods

This study employs a 3D Computational Fluid Dynamics (CFD) model to quantitatively analyze the cavitation risk on the aging concrete surface of the Chay 5 spillway in Ha Giang, Vietnam, under various operation scenarios. There are two standards used to measure cavitation: the cavitation index (σ) which indicates the danger due to the drop of pressure in rapid flow, and the new gasification index (β) which takes into consideration the formation and collapse of bubbles behind asperities.

Results

Three extreme flood cases may not result in potential cavitation because both σ and β exceed critical thresholds. Regarding the six controlled gate scenarios with normal water level, the σ profiles are approximated 1,0 showing a low likelihood of cavitation damage while the β values are smaller than 0.8, indicating a considerable risk of cavitation. Besides, the opening height of 100 cm poses the greatest risk of creating severe cavitation erosion in the concave area and slope portion. The flip bucket experienced the most vulnerable cavitation when the opening height is 400 cm. In addition, an approach to spillway surface rehabilitation involving specialized mortars has been presented.

Conclusion

For aging conveyance structure, gasification index (β) takes into account irregularities surface, providing a more comprehensive assessment of the likelihood of cavitation damage than cavitation index (σ). After rehabilitation with anti-shrinkage high abrasion resistance mortar, the entire spillway surface is smooth. This allows for reducing the cavitation risk and improvement of life service thereof.
Taxonomic diversity of terrestrial vertebrates in west-central Mexico: Conservation from a multi-taxa perspective
Authors: Álvarez-Grzybowska Eliza , Rosas-Espinoza Verónica Carolina , Peña-Joya Karen Elizabeth , Santiago-Pérez Ana Luisa , Íñiguez-Dávalos Luis Ignacio , Macías-Rodríguez Miguel Ángel , Rodríguez-Zaragoza Fabián Alejandro
Published: October 2024

Multi-taxa approaches are increasingly used because they describe complementary aspects of ecosystem dynamics from a community ecology perspective. In west-central Mexico, the complex biogeography and topography have created an environment where temperate and tropical forests converge, resulting in great biological diversity. Within this region, the Sierra de Quila Natural Protected Area (SQPA) offers an important example for understanding ecological community dynamics. We analyze the taxonomic diversity of terrestrial vertebrates in the SQPA by incorporating taxonomic levels associated with species. We evaluated the taxonomic diversity with i) an average taxonomic distinctiveness analysis (alpha diversity) and ii) an analysis of taxonomic dissimilarity and partitioning of turnover and differences in richness components (beta diversity). Tropical forests boast the highest taxonomic diversity of amphibians, reptiles, and birds, while temperate gallery forests exhibit lower values. Our results showed that terrestrial vertebrate alpha and beta diversity patterns respond mainly to contrasting vegetation types (tropical vs. temperate). Regarding beta diversity, the multi-vegetation type analysis showed the highest values for reptiles, followed by amphibians, birds, and mammals. Turnover had the highest contribution to beta diversity, while differences in richness were relevant for amphibians and reptiles, which could be related to their low mobility and sensitivity to environmental conditions. Despite the local scale, the SQPA presented high beta diversity, reflecting historical ecological processes in taxonomic composition derived from contrasting environments and constraints imposed on species. Evaluating taxonomic structure from a multi-taxa perspective is essential for conservation efforts because it allows the spatial recognition of biological assemblages as a first step for local interventions.
Esszé az individualizmus kudarcáról
Authors: Vassné Técsy Edit
Published: October 2024

Az írás célja annak vizsgálata, milyen markáns nyelvi megformálásai létezhetnek a pusztának, a tanyán élő emberek világának, hogyan állíthatók egymással párhuzamba vagy éppen ellentétbe a kanonizált irodalmi alkotások parasztképe és a személyes önéletírások vallomásai Móricz Zsigmond, Darvas József, Csizmadia Imre, Závada Pál, Szilágyi István írásain keresztül.
Alapvető létviszonyok
Authors: Faragó Kornélia
Published: October 2024

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Kedves Miska bácsi,
Authors: Kiss László
Published: October 2024

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A figyelemről
Authors: Turi Tímea
Published: October 2024

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Isten éltesse a 90 éves Ilia Mihályt!
Authors: Varga Zsuzsanna
Published: October 2024

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Docking and Molecular Dynamic Simulation of Temozolomide with Carbonic Anhydrase XIII
Authors: Meenashi R. , Selvaraju K. , Jayalakshmi P. , Nidhin P.V. , David Stephen A.
Published: October 2024

The effect of inhibition of temozolomide, an alkylating agent widely used in cancer treatments, with carbonic anhydrase XIII protein was investigated using docking studies. The stability of temozolomide in the protein environment was assessed and analyzed by molecular dynamics simulation. The topological and charge density variations of temozolomide were studied in detail to perceive the primary insight of the pharmaceutical actions.
The Igbo Resistance of the Westerners: The Origin and One of the Reasons Behind the Hatred Against Them.
Authors: Ugwu Abel Friday
Published: October 2024

This paper explores the historical resistance to Western colonialism and its roots in cultural identity and autonomy. It examines key factors that fueled animosity toward the Igbo, including economic exploitation and cultural dislocation imposed by colonial powers. The analysis highlights how these dynamics contributed to a legacy of mistrust and conflict, shaping perceptions of the Igbo in both historical and contemporary contexts. Through a critical examination of primary and secondary sources, the study aims to shed light on the complexities of Igbo resistance and its enduring impact on their social and political landscape.
MANAGING STARTUPS AS AN ENTREPRENEUR: A CASE STUDY OF LAGOS, NIGERIA
Authors: ONI JOHN SEMAWON
Published: October 2024

AbstractThis paper explores the challenges and strategies of managing startups in Lagos, Nigeria, focusing on key entrepreneurial activities. Lagos is the economic hub of Nigeria, with a rapidly growing ecosystem of startups. The article examines the unique environmental factors, such as access to capital, regulatory challenges, market opportunities, and talent acquisition, that affect the success of startups in the region. By using qualitative data from startup founders, this study identifies best practices and key challenges faced by entrepreneurs in Lagos. The findings highlight the importance of innovation, adaptability, and resource management in sustaining new ventures.
O ESTÁGIO SUPERVISIONADO EM EDUCAÇÃO FÍSICA ESCOLAR COMO ESPAÇO FORMATIVO E DE CONSTRUÇÃO DO SABER ENSINAR
Authors: Silva Correia Mesaque , Gabriela Marques Bruna
Published: October 2024

O objetivo deste estudo foi investigar como ocorre o processo de tornar-se docente no Estágio Supervisionado (ES). Adotamos a pesquisa qualitativa-narrativa e o memorial de formação a fim de provocar nos participantes o reencontro com sua(s) experiência(s) e vivência(s) no ES. O locus da investigação foi o curso de Educação Física da Universidade Federal do Piauí. Quatro discentes do curso de licenciatura regularmente matriculados no oitavo semestre, na disciplina de ES IV, participaram do estudo. Os dados foram analisados por meio da técnica de análise de conteúdo e foram classificados em quatro eixos temáticos: (1) Formação acadêmica e prática pedagógica: articulação possível; (2) ES e saberes docentes: saberes construídos; (3) O tornar-se docente no ES: experiências marcantes e (4) O ES e a prática pedagógica: encontros e desencontros. Os resultados da pesquisa evidenciam que os discentes concebem a relação entre formação acadêmica e ES como sendo um elemento fundante do saber ensinar e alegam que o desenvolvimento da prática pedagógica permite ressignificar o saber fazer. A formação acadêmica permite, ainda, o acesso à fundamentação teórica que orienta a refletir, construir e reconstruir conhecimentos e métodos de ensino necessários à atuação docente na regência de classe do ES.