bluuebunny/crossref_metadata_2025 huggingface dataset:
Flexible Green Ammonia Production Plants: Small-Scale Simulations Based on Energy Aspects
Authors: de la Hera Guillermo , Ruiz-Gutiérrez Gema , Viguri Javier R. , Galán Berta
Published: April 2024

The conventional Haber–Bosch process (HBP) for NH3 production results in CO2 emissions of almost 400 Mt/y and is responsible for 1–2% of global energy consumption; furthermore, HBP requires large-scale industrial equipment. Green or e-ammonia produced with hydrogen from alkaline water electrolysis using renewable energy and nitrogen from the air is considered an alternative to fossil-fuel-based ammonia production. Small-scale plants with the distributed on-site production of e-ammonia will begin to supplant centralized manufacturing in a carbon-neutral framework due to its flexibility and agility. In this study, a flexible small-scale NH3 plant is analyzed with respect to three steps—H2 generation, air separation, and NH3 synthesis—to understand if milder operating conditions can benefit the process. This study investigates the aspects of flexible small-scale NH3 plants powered by alkaline electrolyzer units with three specific capacities: 1 MW, 5 MW, and 10 MW. The analysis is carried out through Aspen Plus V14 simulations, and the primary criteria for selecting the pressure, temperature, and number of reactors are based on the maximum ammonia conversion and minimum energy consumption. The results show that: (i) the plant can be operated across a wide range of process variables while maintaining low energy consumption and (ii) alkaline electrolysis is responsible for the majority of energy consumption, followed by the ammonia synthesis loop and the obtention of N2, which is negligible.
Research on Secure Community Opportunity Network Based on Trust Model
Authors: Su Bing , Liang Jiwu
Published: April 2024

With the innovation of wireless communication technology and the surge of data in mobile networks, traditional routing strategies need to be improved. Given the shortcomings of existing opportunistic routing strategies in transmission performance and security, this paper proposes a community opportunistic routing decision-making method based on the trust model. This algorithm calculates the node’s trust value through the node’s historical forwarding behavior and then calculates the node’s trust value based on the trust model. Thresholds and trust attenuation divide dynamic security communities. For message forwarding, nodes in the security community are prioritized as next-hop relay nodes, thus ensuring that message delivery is always in a safe and reliable environment. On this basis, better relay nodes are further selected for message forwarding based on the node centrality, remaining cache space, and remaining energy, effectively improving the message forwarding efficiency. Through node trust value and community cooperation, safe and efficient data transmission is achieved, thereby improving the transmission performance and security of the network. Through comparison of simulation and opportunistic network routing algorithms, compared with traditional methods, this strategy has the highest transmission success rate of 81% with slightly increased routing overhead, and this algorithm has the lowest average transmission delay.
Fire as a Factor in the Dynamics of Meadow Vegetation: A Model Experiment in Western Siberia
Authors: Lednev Sergey , Kasymov Denis , Semenkov Ivan , Klink Galya , Agafontsev Mikhail , Koroleva Tatyana
Published: April 2024

The state of meadow vegetation in areas with different ages of experimental spring burnout (from 1 to 12 years ago) was studied in the Tomsk region for 3 years. On experimental plots of 1 m2 and 100 m2 (small- and middle-scale levels, respectively), the dynamics of species richness, total projective cover of vegetation, and aboveground phytomass reserves were characterized, and the structure of communities was analyzed. It was revealed that a single fire in the spring significantly reduces species richness for small-scale plots and increases the total projective cover for middle-scale plots. Structural differences from control plots can be traced from 1 to 4 years for different characteristics. The effects of fire are more prominent for small-scale plots. To suppress tree growth and maintain the existence of meadows, grass fires seem to be a less effective practice than mowing. At the same time, the results obtained potentially allow us to consider prescribed burning as a tool for maintaining the stability of meadow plant communities in the south of Western Siberia, preventing them from becoming overgrown with tree undergrowth, in cases with a controlled frequency of burning and the use of appropriate fire safety measures.
Age, Growth, and Mortality of Pontic Shad, Alosa immaculata Bennett, 1835, in the Danube River, Romania
Authors: Stroe Desimira Maria , Cretu Mirela , Tenciu Magdalena , Dima Floricel Maricel , Patriche Neculai , Tiganov George , Dediu Lorena
Published: April 2024

This study aimed to evaluate the growth, mortality parameters, and exploitation rate of Pontic shad, Alosa immaculata Benett, 1835, in the Danube River, Romania (km 169–197). The sampling collection started with the first signs of Pontic shad migration, on 4 March 2023, and continued weekly until the beginning of June 2023, when the last specimens were caught in the nets. The estimation of the growth, mortality parameters, and exploitation rate was done in FiSAT (FAO-ICLARM Stock Assessment Tools). The von Bertalanffy growth equation was estimated at L∞ = 36.75 cm, the growth coefficient was k = 0.68 year−1, and the theoretical initial age was t0 = −0.67 year−1. The total mortality rate (Z) estimated was 2.76 year−1, with a natural mortality rate (M) and fishing mortality rate (F) of 0.89 year−1 and 1.87 year−1, respectively. The Z/k ratio was found to be 4.11 and the exploitation rate (E) was estimated at 0.68 year−1, indicating the overexploitation of Alosa immaculata stocks. In conclusion, this study provides valuable insights into the population dynamics of Pontic shad in the Danube River, Romania. The assessments of the growth parameters, mortality rates, and exploitation rates highlight a level of overexploitation of Alosa immaculata stocks. These findings underscore the importance of applying effective fishery management strategies to ensure the sustainability and conservation of this valuable fish species in the Danube River ecosystem.
Turbulent Flow Prediction-Simulation: Strained Flow with Initial Isotropic Condition Using a GRU Model Trained by an Experimental Lagrangian Framework, with Emphasis on Hyperparameter Optimization
Authors: Hassanian Reza , Aach Marcel , Lintermann Andreas , Helgadóttir Ásdís , Riedel Morris
Published: April 2024

This study presents a novel approach to using a gated recurrent unit (GRU) model, a deep neural network, to predict turbulent flows in a Lagrangian framework. The emerging velocity field is predicted based on experimental data from a strained turbulent flow, which was initially a nearly homogeneous isotropic turbulent flow at the measurement area. The distorted turbulent flow has a Taylor microscale Reynolds number in the range of 100 < Reλ < 152 before creating the strain and is strained with a mean strain rate of 4 s−1 in the Y direction. The measurement is conducted in the presence of gravity consequent to the actual condition, an effect that is usually neglected and has not been investigated in most numerical studies. A Lagrangian particle tracking technique is used to extract the flow characterizations. It is used to assess the capability of the GRU model to forecast the unknown turbulent flow pattern affected by distortion and gravity using spatiotemporal input data. Using the flow track’s location (spatial) and time (temporal) highlights the model’s superiority. The suggested approach provides the possibility to predict the emerging pattern of the strained turbulent flow properties observed in many natural and artificial phenomena. In order to optimize the consumed computing, hyperparameter optimization (HPO) is used to improve the GRU model performance by 14–20%. Model training and inference run on the high-performance computing (HPC) JUWELS-BOOSTER and DEEP-DAM systems at the Jülich Supercomputing Centre, and the code speed-up on these machines is measured. The proposed model produces accurate predictions for turbulent flows in the Lagrangian view with a mean absolute error (MAE) of 0.001 and an R2 score of 0.993.
Computational Analysis of Blood Flow in Healthy Pulmonary Arteries in Comparison to Repaired Tetralogy of Fallot Results: A Small Cohort Study
Authors: Boumpouli Maria , Black Scott MacDonald , Kazakidi Asimina
Published: April 2024

Characterization of the physiological hemodynamic environment in normal pulmonary arteries is a key factor in understanding pathological conditions. This study aimed to analyze the morphology and hemodynamics in the healthy adult pulmonary bifurcation in comparison to age-matched repaired Tetralogy of Fallot (rTOF) geometries. The pulmonary trunk of five healthy volunteers was reconstructed from 4D Flow-MRI data and was compared to rTOF results. Subject-specific boundary conditions were assigned in both the inlet and outlets of the models, and flow characteristics were analyzed computationally. The morphological and flow features were consistent among the healthy geometries, highlighting the ability of an averaged geometry derived from this small cohort to capture the main flow characteristics. A slightly higher mean time-averaged wall shear stress (TAWSS) was found in the right pulmonary artery, which was also the branch with a higher mean curvature and local Reynolds number. Compared to rTOF results, the averaged healthy geometry demonstrated more than an 8-fold lower value in TAWSS, with the individual patient-specific healthy volunteers showing further reduced TAWSS than the rTOF patients. These observations could be useful in clinical assessment and decision making based on hemodynamic indices.
Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management
Authors: Viana Cabral Fernanda , Quilez Alburquerque Jose , Roberts Harrison James , Hasan Tayyaba
Published: April 2024

The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. This review explores the principles of PDT and discusses the concept of photodynamic priming (PDP), which augments the effectiveness of treatments like chemotherapy. Furthermore, the integration of nanotechnology for precise drug delivery at the right time and location and PDT optimization are examined. Ultimately, this study highlights the potential and limitations of PDT and PDP in cancer treatment paradigms, offering insights into future clinical applications.
Functional Analysis of β-Carotene Oxygenase 2 (BCO2) Gene in Yesso Scallop (Patinopecten yessoensis)
Authors: Liu Shiqi , Wang Shuyue , Zhao Liang , Li Tingting , Zhang Yihan , Wang Huizhen , Bao Zhenmin , Hu Xiaoli
Published: April 2024

Carotenoids are essential nutrients for humans and animals, and carotenoid coloration represents an important meat quality parameter for many farmed animals. Increasingly, studies have demonstrated that vertebrate carotenoid cleavage oxygenases (CCOs) are essential enzymes in carotenoid metabolism and are therefore potential candidate genes for improving carotenoid deposition. However, our understanding of carotenoid bioavailability and CCOs functions in invertebrates, particularly marine species, is currently quite limited. We previously identified that a CCO homolog, PyBCO-like 1, was the causal gene for carotenoid coloration in the ‘Haida golden scallop’, a variety of Yesso scallop (Patinopecten yessoensis) characterized by carotenoid enrichment. Here, we found that another CCO-encoding gene named PyBCO2 (β-carotene oxygenase 2) was widely expressed in P. yessoensis organs/tissues, with the highest expression in striated muscle. Inhibiting BCO2 expression in P. yessoensis through RNA interference led to increased carotenoid (pectenolone and pectenoxanthin) deposition in the striated muscle, and the color of the striated muscle changed from white to light orange. Our results indicate that PyBCO2 might be a candidate gene used for improving carotenoid content in normal Yesso scallops, and also in ‘Haida golden scallops’.
Overexpression of miR-25 Downregulates the Expression of ROBO2 in Idiopathic Intellectual Disability
Authors: Ordoñez-Razo Rosa María , Gutierrez-López Yessica , Araujo-Solis María Antonieta , Benitez-King Gloria , Ramírez-Sánchez Israel , Galicia Gabriela
Published: April 2024

Idiopathic intellectual disability (IID) encompasses the cases of intellectual disability (ID) without a known cause and represents approximately 50% of all cases. Neural progenitor cells (NPCs) from the olfactory neuroepithelium (NEO) contain the same information as the cells found in the brain, but they are more accessible. Some miRNAs have been identified and associated with ID of known etiology. However, in idiopathic ID, the effect of miRNAs is poorly understood. The aim of this study was to determine the miRNAs regulating the expression of mRNAs that may be involved in development of IID. Expression profiles were obtained using NPC–NEO cells from IID patients and healthy controls by microarray. A total of 796 miRNAs and 28,869 mRNAs were analyzed. Several miRNAs were overexpressed in the IID patients compared to controls. miR-25 had the greatest expression. In silico analysis showed that ROBO2 was the target for miR-25, with the highest specificity and being the most down-regulated. In vitro assay showed an increase of miR-25 expression induced a decrease in ROBO2 expression. In neurodevelopment, ROBO2 plays a crucial role in episodic learning and memory, so its down-regulation, caused by miR-25, could have a fundamental role in the intellectual disability that, until now, has been considered idiopathic.
Modelling Method for Aeroelastic Low Engine Order Excitation Originating from Upstream Vanes’ Geometrical Variability
Authors: Gambitta Marco , Beirow Bernd , Schrape Sven
Published: April 2024

The manufacturing geometrical variability in axial compressors is a stochastic source of uncertainty, implying that the real geometry differs from the nominal design. This causes the real geometry to lose the ideal axial symmetry. Considering the aerofoils of a stator vane, the geometrical variability affects the flow traversing it. This impacts the downstream rotor, especially when considering the aeroelastic excitation forces. Optical surface scans coupled with a parametrisation method allow for acquiring the information relative to the real aerofoils geometries. The measured data are included in a multi-passage and multi-stage CFD setup to represent the mistuned flow. In particular, low excitation harmonics on the rotor vane are introduced due to the geometrical deviations of the upstream stator. The introduced low engine orders, as well as their amplitude, depend on the stator geometries and their order. A method is proposed to represent the phenomena in a reduced CFD domain, limiting the size and number of solutions required to probabilistically describe the rotor excitation forces. The resulting rotor excitation forces are reconstructed as a superposition of disturbances due to individual stator aerofoils geometries. This indicates that the problem is linear in the combination of disturbances from single passages.
A Construction Morphology Approach to Neoclassical Compounds and the Function of the Linking Vowel
Authors: Hayashi Hiromi
Published: April 2024

The morphological status of combining-forms (CF) (bio-, -logy, etc.) used in neoclassical compounds (biology, bioscience, etc.) is a matter of debate in morphology. Some see them as having the same status as ordinary words, while others see them as having a special status and forming an independent category. This paper focuses on neoclassical compounds having basic and extended patterns. The former, biology type, is composed solely of CFs, while the latter contains ordinary words, i.e., free morphemes (FM), and is further classified into two categories: bioscience type and hamburgerology type. This paper aims to explain the relationship among those subtypes of neoclassical compounds while capturing their extension processes within the framework of Construction Morphology (CxM). In particular, we outline a novel analysis of those subtypes of neoclassical compounds using “schemas” and “constructional idioms” following the literature regarding CxM.
The Preparation of an Ultrafine Copper Powder by the Hydrogen Reduction of an Ultrafine Copper Oxide Powder and Reduction Kinetics
Authors: Li Shiwen , Pang Jianming , Han Wei , Luo Lingen , Cheng Xiaoyu , Zhao Zhimin , Lv Chaoran , Liu Jue
Published: April 2024

Ultrafine copper powders were prepared by the air-jet milling of copper oxide (CuO) powders and a subsequent hydrogen (H2) reduction. After milling, the particle size and grain size of CuO powders decreased, while the specific surface area and structural microstrain increased, thereby improving the reaction activity. In a pure H2 atmosphere, the process of CuO reduction was conducted in one step, and followed a pseudo-first-order kinetics model. The smaller CuO powders after milling exhibited higher reduction rates and lower activation energies compared with those without milling. Based on the unreacted shrinking core model, the reduction of CuO powders via H2 was controlled by the interface reaction at the early stage, whereas the latter was limited by the diffusion of H2 through the solid product layer. Additionally, the scanning electron microscopy (SEM) indicated that copper powders after H2 reduction presented a spherical-like shape, and the sintering and agglomeration between particles occurred after 300 °C, which led to a moderate increase in particle size. The preparing parameters (at 400 °C for 180 min) were preferred to obtain ultrafine copper powders with an average particle size in the range of 5.43–6.72 μm and an oxygen content of less than 0.2 wt.%.
Synthesis, Characterization, and Properties of a Novel Hyperbranched Polymers with Polyacrylamide Side Chains
Authors: Qin Xiaoping , Wang Qianwen , Tang Peng , Yang Hui , Li Cuixia , Yang Xiaoliang , Peng Tong
Published: April 2024

A novel hyperbranched polymer with polyacrylamide side chains (HAPAM) was synthesized by aqueous solution polymerization using acrylic acid, acrylamide, 2-acrylamido-2-methyl-1-propanesulfonic acid, hydrophobic monomer of dimethyl octadecyl ammonium chloride, and the homemade skeleton monomer of modified-M2.0 as raw materials and (NH4)2S2O8-NaHSO3 as initiator. The molecular structure, functional groups, and surface morphology of HAPAM were characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance hydrogen spectroscopy, and scanning electron microscopy. It was found that the performance of HAPAM solution was higher than that of ordinary polyacrylamide solution in terms of thickening ability, shearing resistance, thermal endurance, salt-resistance, resistance-coefficient and residual-resistance-coefficient, ability to reduce interfacial tension between polymer solution and crude oil, and oil-displacement-efficiency. In particular, the enhanced oil recovery of the HAPAM solution was 13.03%, and the improvement of shearing resistance and immunity to chromatographic separation were simultaneously achieved by the HAPAM solution. These results indicate that the successful synthesis of the novel HAPAM opens a promising strategy for developing new high-performance oil-displacing polymers.
Experimental and FEM Studies of Continuous Drive Friction Welding of Ferritic Spheroidal Graphite Cast Iron
Authors: Winiczenko Radosław , Skibicki Andrzej
Published: April 2024

Experimental and FEM studies of the friction welding process of spheroidal graphite cast iron (SGCI) are presented. A coupled thermal and mechanical 2.5 D FEM model was used to simulate the continuous drive friction welding (CDFW) process. The FE model predicted the peak temperature of the joint, effective stress, axial shortening, and the weld flash size. Additionally, the friction force on the axial shortening of specimens was studied. The peak temperatures were measured both on the axis and at the surface of the specimen. The predicted maximum temperatures in the axis, ½ radius, and 2 mm from the surface of the sample amounted to 1162 °C, 1177 °C, and 1061 °C, respectively. The maximum temperature of the spheroidal graphite cast iron joint was below the melting temperature of the base material (~1350 °C). The predicted temperature curves, outbursts, and shortening of welded elements indicated a good match with real models.
Dynamics of Identities: Jewish Communities in Africa and Their Diaspora
Authors: Sharaby Rachel
Published: April 2024

This Special Book deals with the study of Jewish communities in Africa and their Diaspora [...]
Classification of Corrosion Severity in SPCC Steels Using Eddy Current Testing and Supervised Machine Learning Models
Authors: Xie Lian , Baskaran Prashanth , Ribeiro Artur L. , Alegria Francisco C. , Ramos Helena G.
Published: April 2024

Steel Plate Cold-Rolled Commercial (SPCC) steel is known to have long-term durability. However, it still undergoes corrosion when exposed to corrosive environments. This paper proposes an evaluation method for assessing the corrosion level of SPCC steel samples using eddy current testing (ECT), along with two different machine learning approaches. The objective is to classify the corrosion of the samples into two states: a less corroded state (state-1) and a highly corroded state (state-2). Generative and discriminative models were implemented for classification. The generative classifier was based on the Gaussian mixture model (GMM), while the discriminative model was based on the logistic regression model. The features used in the classification models are the peaks of the perturbated magnetic fields at two different frequencies. The performance of the classifiers was evaluated using metrics such as absolute error, accuracy, precision, recall, and F1 score. The results indicate that the GMM model is more conducive to categorizing states with higher levels of corrosion, while the logistic regression model is helpful in estimating states with lower levels of corrosion. Meanwhile, high classification accuracy can be achieved based on both methods using eddy current testing.
Improved Hybrid Model for Obstacle Detection and Avoidance in Robot Operating System Framework (Rapidly Exploring Random Tree and Dynamic Windows Approach)
Authors: Adiuku Ndidiamaka , Avdelidis Nicolas P. , Tang Gilbert , Plastropoulos Angelos
Published: April 2024

The integration of machine learning and robotics brings promising potential to tackle the application challenges of mobile robot navigation in industries. The real-world environment is highly dynamic and unpredictable, with increasing necessities for efficiency and safety. This demands a multi-faceted approach that combines advanced sensing, robust obstacle detection, and avoidance mechanisms for an effective robot navigation experience. While hybrid methods with default robot operating system (ROS) navigation stack have demonstrated significant results, their performance in real time and highly dynamic environments remains a challenge. These environments are characterized by continuously changing conditions, which can impact the precision of obstacle detection systems and efficient avoidance control decision-making processes. In response to these challenges, this paper presents a novel solution that combines a rapidly exploring random tree (RRT)-integrated ROS navigation stack and a pre-trained YOLOv7 object detection model to enhance the capability of the developed work on the NAV-YOLO system. The proposed approach leveraged the high accuracy of YOLOv7 obstacle detection and the efficient path-planning capabilities of RRT and dynamic windows approach (DWA) to improve the navigation performance of mobile robots in real-world complex and dynamically changing settings. Extensive simulation and real-world robot platform experiments were conducted to evaluate the efficiency of the proposed solution. The result demonstrated a high-level obstacle avoidance capability, ensuring the safety and efficiency of mobile robot navigation operations in aviation environments.
Scalable Learning Framework for Detecting New Types of Twitter Spam with Misuse and Anomaly Detection
Authors: Choi Jaeun , Jeon Byunghwan , Jeon Chunmi
Published: April 2024

The growing popularity of social media has engendered the social problem of spam proliferation through this medium. New spam types that evade existing spam detection systems are being developed continually, necessitating corresponding countermeasures. This study proposes an anomaly detection-based framework to detect new Twitter spam, which works by modeling the characteristics of non-spam tweets and using anomaly detection to classify tweets deviating from this model as anomalies. However, because modeling varied non-spam tweets is challenging, the technique’s spam detection and false positive (FP) rates are low and high, respectively. To overcome this shortcoming, anomaly detection is performed on known spam tweets pre-detected using a trained decision tree while modeling normal tweets. A one-class support vector machine and an autoencoder with high detection rates are used for anomaly detection. The proposed framework exhibits superior detection rates for unknown spam compared to conventional techniques, while maintaining equivalent or improved detection and FP rates for known spam. Furthermore, the framework can be adapted to changes in spam conditions by adjusting the costs of detection errors.
Clinical progression of parotid salivary gland sialadenosis based on the selected H. pylori eradication therapy
Authors: Konovalova Т. А. , Kozlova M. V. , Chorbinskaya S. A. , Purveeva K. V.
Published: April 2024

Relevance. In approximately 50.82% of instances, sialadenosis of the parotid salivary gland (PSG) emerges as a sequel to gastrointestinal (GI) disorders. This condition is characterized by diminished saliva production (hyposalivation) and enlargement (hypertrophy) of the gland. In Russia, the prevalence of GI diseases linked to acid-related issues and H. pylori infection (HP) is notably high. The therapeutic approach to this pathology focuses on the eradication of HP, employing various treatment strategies that incorporate the use of a proton pump inhibitor (PPI). The efficacy of PPIs hinges on their ability to inhibit the proton pump, which is situated in the endothelial lining of the smooth muscle vessels, including those that encase the acinar cells of the PSG. An essential aspect of parotid secretion is its protective role, which is executed through the production of secretory immunoglobulin A (sIgA) within the gland's ductal system. Therefore, exploring the clinical progression of PSG sialadenosis under eradication therapy regimens holds substantial significance.

Materials and methods. Between 2021 and 2023, 80 patients with parotid salivary gland (PSG) sialadenosis and Helicobacter pylori stomach infection were studied. They were divided into treatment groups: Group I (25 patients, aged 45.81 ± 6.39 years) received quadruple therapy (standard-dose PPI, amoxicillin 1,000 mg, clarithromycin 500 mg twice daily, and bismuthate tripotassium dicitrate 120 mg four times daily); Group II (55 patients, aged 47.79 ± 7.15 years) underwent standard triple therapy (double-dose PPI, amoxicillin 1,000 mg, and clarithromycin 500 mg twice daily). A control group consisted of 20 nearly healthy individuals (average age 26.46 ± 4.12 years). All subjects underwent comprehensive dental and PSG assessments, including questionnaires, sialometry, and measurement of (sIgA) levels in parotid secretion.

Results. After eradication therapy, Group I patients treated with quadruple therapy exhibited a 1.2-fold reduction in PSG secretory function (p = 0.048) and a 1.2-fold decrease in sIgA concentration (p = 0.035) compared to initial levels. Group II patients receiving triple therapy demonstrated a significant 3.6-fold decline in PSG sialometry parameters (p = 0.002) and a 1.8-fold reduction in sIgA levels (p = 0.006) by the 14th day post-eradication, relative to pre-treatment figures.

 Conclusion. Therefore, patients with GI acid-related conditions linked to HP infection should be evaluated by a dentist for potential PSG sialadenosis. The presence of PSG sialadenosis in individuals with HP stomach infection warrants consideration in the selection and administration of eradication therapy.
Süddî’nin Hadis İlmindeki Mevsukiyeti
Authors: Dağlıoğlu Ufuk
Published: April 2024

Süddî (ö. 127/745), tefsir dalında kendisinden çokça söz edilen şahsiyetlerdendir. Onun bu alandaki yetkinliğini kabul edenler yanında yetersiz olduğu kanaatini taşıyanlar da vardır. Kimileri tarafından o, Şiîlik’le itham edilmiş, bazılarına göre de Şîa’nın muteber kabul ettiği bir şahıs addedilmiştir. Hadis müellefâtında yer alan bazı rivayetlere göre Süddî, kezzâb râvi vasfıyla tavsif edilirken bazı rivayetlerde ise güvenilir biri olarak nitelendirilmiştir. Şu durumda Süddî’nin hadis alanındaki mevsukiyetinin araştırılması önem arz etmektedir. Süddî üzerine yaptığımız araştırmada onun hadisle irtibatına değinilmediği, münekkitlerce onu mecrûh kılan bazı rivayetlere yer verilmekle iktifa edilerek rivayetlerin güvenilirliği üzerinde durulmadığı fark edilmiştir. Bundan dolayıdır ki onun ilmî hayatı ve mevsukiyeti, tabakât, ricâl ve cerh – ta‘dîl eserlerinde yer alan kayıtlarla ortaya konularak Kütüb-i Sitte ve diğer hadis musannefâtında yer alan rivayetleri araştırılmıştır. Süddî’nin güvenilir bir râvi olduğuna dair görüşlerle onu tenkit edenlerin delillerine yer verilmiştir. Böylelikle onun cerhinde etkili olan teşeyyu‘ ve kizb ithamlarının gerçeği yansıtıp yansıtmadığı tespit edilmeye çalışılmıştır.
The impact of leadership style in team-based primary care – staff satisfaction and motivation
Authors: Bhatti Sara , Bale Stephanie , Gul Sehar , Muldoon Laura , Rayner Jennifer
Published: April 2024

Background

Leadership styles, beliefs, and behaviours are an important and critical component to the delivery of quality care in any primary care organisation. The human resource crisis in health care has resulted in greater investments in team-based care; however, some leaders may not have experience working in team-based settings.

Aim

To explore what leadership characteristics, styles, and behaviours were most conducive to employee satisfaction, motivation, and delivery of care in a team-based primary care setting.

Design & setting

A qualitative study involving 16 community health centre (CHC) staff from six CHCs across Ontario, Canada.

Method

Thematic analysis of qualitative interviews using a framework based on transformational leadership (TL) theory.

Results

The following three themes emerged from our findings as having a noticeable impact on staff motivation, morale, delivery of care, and client outcomes: transparent and open communication; opportunities to collaborate in decision making; and staff recognition and appreciation. The results of our study indicate it is critical that leaders adopt leadership styles and approaches in which every team member is informed, heard, and appreciated.

Conclusion

This study described the leadership styles and characteristics that lead to improved employee satisfaction, motivation, and morale in a team-based primary care setting, and the impact this could and does have on quality and delivery of care. Future research is needed to better understand the impact of leadership in a variety of roles within a team-based environment, specifically in a multidisciplinary setting.
Valorisation of certain cultivated legumes using recent biotechnological approaches for the elaboration of new gluten-free products in Algeria
Authors: Ammouche Zahia , Mahdi Khadidja , Siham Agrane-Sayah , Boutera Nacera , Cherief Abdelkader , Mimeche Fateh
Published: April 2024

The aim of this study was to develop gluten-free food products, a biscuit (cookies) and a pasta (couscous) based on chickpea flour and fava bean flour, in order to improve and diversify food products for Algerian coeliac patients. The choice of raw material was based partly on the nutritional richness of these varieties, especially in terms of proteins and the balance of their amino acid profiles, and partly on their availability and low cost.The physico-chemical analyses carried out show that the raw materials and finished products produced are of good quality. The sensory analysis carried out shows that the cooked biscuits and couscous made are well appreciated by tasters and have better organoleptic characteristics. However, these results remain preliminary and should be followed up with further work to create a formula that meets the requirements of coeliac patients.
Tumor de Frantz: relato de caso e revisão de literatura
Authors: Costa Leandro Moraes , Val Jhamille Amanda Cardoso do , Nascimento Júlio Gomes do , Rodriguez Juan Eduardo Rios , Lima Guilherme dos Santos , Seabra Daniel Brendon Melo Henriques , Machado Danielle Alcântara Barbosa , Souza Raymison Monteiro de
Published: April 2024

Introdução: Tumor de Frantz é um tumor pseudopapilar ou sólido cístisco do pâncreas, geralmente assintomático e achado incidentalmente durante exames de imagem. O seu diagnóstico é realizado com tomografia ou ressonância e seu tratamento é cirúrgico. Objetivo: Relatar um caso de tumor de Frantz em paciente jovem oligossintomática Relato: Paciente do sexo feminino, 13 anos, com queixas de dor abdominal sem causa. Após tomografia e ressonância, identificado neoplasia em cauda de pâncreas, sendo optado por pancreatectomia corpocaudal. Discussão: O tumor de Frantz foi inicialmente descrito em 1959, e desde então, pela epidemiologia o tumor é conhecido como neoplasia de mulheres jovens, já que esta é a principal faixa populacional. O tratamento cirúrgico é o tratamento padrão-ouro e tem bons resultados quando a paciente tem sintomas. Conclusões: A utilização de exames de imagem é imprescindível para avaliação de tumor de Frantz, e mesmo apresentando baixa incidência, deve ser colocada como opção a causa de dor abdominal
A importância do cirurgião-dentista nos cuidados com pacientes oncológicos em estágio terminal-revisão de literatura
Authors: Correia Igor Ancelmo Silva , Silva Gabriel Teixeira da , Moura Luiz Felipe de Costa , Araújo Pedro Henrique Pereira , Souza Ana Beatriz Lemos , Santos Davi Antunes dos , Cardozo Jéssica do Nascimento , Braz Louriane Fernandes
Published: April 2024

Os cuidados paliativos têm por função promover um bem-estar aos pacientes em fase terminal, promovendo a qualidade de vida e auxiliando no processo de aceitação. Embora ainda haja certa desvalorização, o cirurgião-dentista tem papel fundamental desde antes do diagnóstico até o fim do tratamento antineoplásico, atuando no tratamento e prevenção de complicações resultantes de procedimentos para tratamentos oncológicos, além de controle de infecções oportunistas, auxílio em dificuldades respiratórias e de deglutição e questões estéticas e fonéticas. As pesquisas, para produção científica deste artigo, foram realizadas a partir do método de revisão bibliográfica, sobre a importância do cirurgião-dentista nos cuidados com pacientes oncológicos em estágio terminal, utilizando-se a base de dados Google Acadêmico, por meio de uma análise qualitativa, a fim de excluir trabalhos que destoam do foco de interesse e apresentam duplicidade. O objetivo deste trabalho é analisar a importância do cirurgião-dentista nos cuidados com pacientes oncológicos em estágio terminal e a partir disto conclui-se que o cuidado multidisciplinar, incluindo cirurgiões-dentistas é fundamental para o bem-estar e maior conforto do paciente oncológico em estágio terminal.
Ileus Biliar - uma causa rara de oclusão intestinal
Authors: Ribeiro Ricardo Miguel Carvalho , Cardoso Paulo , Santos Florissandra
Published: April 2024

Introdução: O ileus biliar é uma causa incomum de oclusão intestinal mecânica. Caracteriza-se pelo encravamento de um cálculo biliar no trato gastrointestinal, habitualmente no intestino delgado. Estima-se que ocorra em menos de 1% dos doentes com colelitíase. Relato de caso: Apresentamos uma caso de oclusão intestinal de etiologia biliar, com necessidade de tratamento cirúrgico.Conclusão: Os sintomas desta patologia são inespecíficos. Deve ser suspeitada nos quadros de dor abdominal associada a vómitos, sendo o seu diagnóstico confirmado por métodos de imagem. O tratamento desta patologia é cirúrgico.
Avaliação de discentes sobre conhecimentos técnicos e procedimentais necessários para aplicação de injetáveis intramusculares
Authors: Oliveira Laryssa Candida de , Faria Tatiane Mendes , Bernardino Júnior Roberto
Published: April 2024

Esse estudo objetiva avaliar o conhecimento de discentes que estejam nos dois últimos anos do curso de graduação em enfermagem e discentes do último ano do curso técnico em enfermagem do município de Uberlândia acerca da realização correta da técnica de administração de injetáveis por via intramuscular e das estruturas anatômicas de cada região nas quais a administração pode ser realizada. Trata-se de um estudo quanti-qualitativo e descritivo, realizado com 25 alunos do curso técnico em enfermagem e 25 discentes da graduação em enfermagem da cidade de Uberlândia, Minas Gerais, Brasil, no período de dezembro 2022 a março de 2023. Para análise estatística foram cruzados os resultados de cada pergunta entre os dois grupos analisados utilizado o teste de Kappa com p<0,05 e ainda os dados foram submetidos à descrição de porcentagem. Após análise estatística os cruzamentos das perguntas “Para realização de injetáveis intramusculares qual número corresponde a angulação da agulha mais recomendada?”; e ”Qual o nome do ponto anatômico, indicado pela seta, que deve ser identificado para realização da injeção?”; deram estatisticamente significativos. Conclui-se que há uma fragilidade do ensino e conhecimento de discentes de nível superior e técnico do município de Uberlândia a respeito da anatomia, morfologia e técnica adequada para aplicação de injetáveis intramusculares.
Câncer gástrico - uma revisão abrangente sobre epidemiologia, etiologia, fatores de risco, diagnóstico, estadiamento, tratamento, prevenção
Authors: Ruas Lorena Rodrigues , Bessas Carolina Duarte Coelho , Monção Gabriela Dezan , Salicio Gabriela Mussato , Biazi Gabriela Saad de , Benevenutti Letícia , Silva Mayara Victória de Sousa , Carmo Marcel Cicuto Ferreira do , Farias Nayron Arthur Correia , Gomes Rayane Lopes
Published: April 2024

O câncer gástrico (CG) é uma neoplasia maligna que se desenvolve no estômago, sendo uma das principais causas de morte por câncer em todo o mundo. Sua incidência varia globalmente, com uma prevalência maior em países asiáticos, como Japão e Coreia do Sul, e uma tendência decrescente em países ocidentais nas últimas décadas. A etiologia do CG é multifatorial, envolvendo fatores genéticos, ambientais e comportamentais. Entre os fatores de risco estão a infecção pelo Helicobacter pylori, dieta rica em alimentos defumados, salgados e em conserva, consumo excessivo de álcool, tabagismo e história familiar de CG. O diagnóstico precoce é crucial para o prognóstico do CG e pode ser realizado por meio de endoscopia digestiva alta com biópsia. O estadiamento da doença é determinado pelo sistema TNM, que leva em consideração o tamanho do tumor, a presença de linfonodos comprometidos e a presença de metástases. O tratamento do CG geralmente envolve uma abordagem multidisciplinar, incluindo cirurgia, quimioterapia, radioterapia e imunoterapia, dependendo do estágio da doença e das características individuais do paciente. Estratégias de prevenção do CG incluem a erradicação do H. pylori em populações de alto risco, adoção de uma dieta balanceada rica em frutas e vegetais e pobre em alimentos processados e defumados, moderação no consumo de álcool e abandono do tabagismo. Programas de rastreamento podem ser implementados em algumas populações de alto risco para detectar precocemente lesões pré-cancerosas ou câncer em estágios iniciais, aumentando assim as chances de cura. Por fim, o conhecimento contínuo sobre os fatores de risco, os avanços no diagnóstico e tratamento e a promoção de estilos de vida saudáveis são essenciais na luta contra o CG.
Cirurgia de controle de danos em vítimas de trauma: compreendendo sua importância e benefícios
Authors: Castro Jamille Lessa , Assis Ádila Gabriela Costa de , Santana Carla Natali de , Oliveira Eli Heryko Barbosa Matos de , Silva Junior Elson Francisco da , Oliveira Jéssica Pará Amaral de , Santana Mariana Gomes , Xavier Kassyo Gabryell Tavares
Published: April 2024

Objetivos: Avaliar o impacto da cirurgia de controle de danos na instabilidade hemodinâmica de pacientes politraumatizados. Metodologia: Revisão integrativa da literatura realizada nas bases de dados Biblioteca Virtual da Saúde (BVS), Google Acadêmico e PubMed, utilizando os descritores em Ciências da Saúde (DeCS): “Procedimentos Cirúrgicos”, “Choque hemorrágico” e “Ferimento e lesões” combinados entre si pelo operador booleano AND. Resultados: A cirurgia para controle de danos é uma abordagem cirúrgica emergente para o tratamento de pacientes gravemente traumatizados. Essa abordagem consiste em realizar uma cirurgia inicial limitada para controlar as lesões mais graves e, em seguida, transferir o paciente para a unidade de terapia intensiva (UTI) para recuperação. A cirurgia para controle de danos tem várias vantagens em comparação com a cirurgia definitiva realizada em um único tempo. As vantagens da cirurgia para controle de danos, incluem desde a redução da mortalidade, com média de sobrevida de 20%, melhora da estabilidade hemodinâmica, o que inicialmente limita a perda de sangue e fluidos, além da redução do risco de complicações, como infecção e falência de múltiplos órgãos. A porcentagem de eficácia da cirurgia para controle de danos varia de acordo com o estudo. Em geral, a cirurgia para controle de danos é eficaz em cerca de 80% dos pacientes gravemente traumatizados. É indicada para pacientes gravemente traumatizados que apresentam instabilidade hemodinâmica, a qual é caracterizada por alterações na pressão arterial, frequência cardíaca e volume de sangue circulante. A instabilidade hemodinâmica pode ser causada por uma variedade de fatores, incluindo hemorragia, choque e lesão de órgãos. Dentre os estudos selecionados, pesquisas estimam que cerca de 10% das pacientes vítimas de trauma necessitam de uma abordagem cirúrgica. A cirurgia pode ser necessária para tratar lesões em qualquer parte do corpo, incluindo o abdômen (62,6%), tórax (72%), crânio, membros e coluna vertebral. Conclusão: Conclui-se, portanto, que a cirurgia para controle de danos é uma abordagem cirúrgica eficaz para o tratamento de pacientes gravemente traumatizados. Essa abordagem reduz a mortalidade, melhora a estabilidade hemodinâmica e reduz o risco de complicações.
Bioequivalence of zolpidem hemitartrate: new formulations of 5 mg SL, 10 mg and 12.5 mg XR and comparison of their bioavailabilities
Authors: Aihara Camila Kaori , Guimarães Camila Leles , Rezende Vinicius Marcondes , Sverdloff Carlos Eduardo , Sessa Renata Gebara de Grande Di , Monaco Thiago de Oliveira , Bellorio Karini Bruno , Vêncio Sérgio Alberto Cunha
Published: April 2024

Objective: To evaluate pharmaceutical bioequivalence between two formulations of 5 mg zolpidem hemitartrate sublingual and, 10 and 12.5 mg extended-release formulations tablets in healthy subjects under fasting and fed conditions. Methods: An open label, monocentric, randomized, 2 x 2 crossover study in 40 healthy adults under fasting conditions comparing two formulations of zolpidem 5mg sublingual tablets. Analyte concentrations in human plasma were determined using a validated liquid chromatography with a tandem mass spectrometer detector method (LC-MS/MS). The same design was utilized to evaluate the other formulations.

Results: Statistical analysis has determined geometric mean of test / reference ratio, confidence intervals, and power of the test to the pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞. The geometric mean ratio (90%CI) of the test drug/reference drug for zolpidem 5mg were 99.89 to 113.57% for Cmax, 97.15% to 108.40% for AUC0-t, and 97.22% to 108.13% for AUC0-∞. Power of the test was 99.35% for Cmax and 100% AUC0-t, and AUC0-∞. Conclusion: Both test and reference are bioequivalent for all formulations and, therefore, they are interchangeable, according to the Brazilian criteria (Anvisa resolution RE nº 1170/2006), since confidence intervals for Cmax and AUC0-t ratios were within 80% and 125%.
Caracterização dos carcinomas mamários de fenótipo triplo negativo em um laboratório privado da cidade de Goiânia, Goiás
Authors: Xavier Fernanda Queiroz , Souza Guilherme Simão , Câmara Miguel Moni Guerra Cunha da , Valle Marcela Guerra do , Alves Fernanda Cunha , Assis Fabriny Carezolli Medeiros de , Takatsu Eduarda , Medeiros Julya Sabino , Araújo Brenda Cristina Nunes de , Rodrigues Igor Resende , Giraldi Neto Luiz , Machado Carolina Campos , Rodrigues Thiago Queirós , Mendonça Filho Flávio Ricardo Borges , Campigotto Roberto Spadoni , Teixeira Louise Carolina Alves , Cardoso Lorena Prado , Oliveira Bruna de Castro , Melo Matheus Augusto Ribeiro , Oliveira Evelyn Corrêa de , Santos Pablyne Clara Gonçalves dos
Published: April 2024

A neoplasia de mama é o tipo de câncer mais frequente entre as mulheres, com uma estimativa de cerca de 66 mil novos casos para cada ano entre 2020-2022. A incidência deste carcinoma, por si só, justifica a necessidade de estudos aprofundados acerca desta temática. Trata-se de um estudo descritivo transversal, que é um estudo utilizado para traçar perfil epidemiológico da doença em questão, podendo-se levantar dados em um ponto no tempo pré-definido. Foram avaliados 6.379 casos de carcinoma mamário invasor, dos quais 817 foram classificados com fenótipo triplo negativo (TN). O ano de 2020 apresentou o maior número de casos TN. A idade das pacientes variou de 23 a 95 anos, com uma média de 51,8 anos. Nesta pesquisa, apenas 12,8% dos casos de carcinoma mamário invasor foram classificados como Triplo-negativo. Este padrão se repete em estudos internacionais, confirmando que este subtipo é ligeiramente mais raro do que os outros. Pesquisas apontaram que apenas 16% das mulheres que tiveram diagnóstico de neoplasia mamária dentre os anos de 2006-2011 no país receberam a classificação Triplo-negativa. Entre os anos de 2015 e 2021, observamos um aumento de cerca de 73% de diagnósticos de carcinoma triplo negativos no laboratório INGOH. Os casos de câncer de mama são caracterizados pelo tipo Ductal não especial, com predomínio do grau 3, mais prevalentes na mama esquerda e provenientes de Core Biopsy e de pacientes com idade acima de 50 anos.