bluuebunny/crossref_metadata_2025 huggingface dataset:
Multidimensional Dynamics and Forecast Models of Network Public Opinions Based on the Fusion of Smart Transportation and Big Data
Authors: Sheng Guojun , Guan Yi
Published: April 2022

With the increase of the world’s population, the means of transportation and vehicles that adapt to the times are still difficult to cope with the increase in traffic volume. The traffic problem can be said to be a worldwide problem. However, with the development of artificial intelligence, the emergence of smart transportation has brought new development to modern transportation, and the application of smart transportation and big data is inseparable. In contemporary society, the widespread use of the Internet allows the public to fully exercise their rights to participate in social management and conduct public opinion supervision, which provides a great impetus for the development of online public opinion. However, due to the huge scale of information, some false and harmful information and opinions will inevitably be mixed into it, which will make the network public opinion unable to perform its due function smoothly. Therefore, it is necessary to carry out highly effective management activities on the network public opinion. This paper studies the multidimensional dynamics and prediction model of network public opinion based on the integration of smart transportation and big data; the aim is to design a simple and effective forecasting model to provide traffic management departments with good public opinion forecasting and analysis methods so as to make better decisions. This paper analyzes the related technologies of smart transportation and network public opinion and designs a prediction model of smart transportation network public opinion. Finally, this paper uses rough set theory to optimize the model and compares the data before and after optimization. The results are as follows: the data correlation coefficient before and after optimization is 0.988, and the two-tailed significance level is 0.471, which proves that the results before and after processing are highly correlated, and the two sets of data have no significant difference, proving that the optimization of the model is effective, simplifies the analysis process, and does not change the results.
Forecasting Algorithm of Regional Economic Development Based on LPSVR
Authors: Zhang Yanxue , Cao Wei
Published: April 2022

As an open and complex giant system, the development factors of regional economy restrict and promote each other and finally bring a high degree of nonlinearity to various data reflecting regional economic development. In addition, due to the difficulty of statistics, economic data has the characteristics of less data and large errors. This article is aimed at studying a regional economic development forecasting algorithm in order to change the traditional forecasting modeling technology that is increasingly difficult to meet the needs of regional economic development forecasting. The management department can analyze the results of the data mining model to improve the administrative management of the management department, later supervision ability, and work efficiency. In this article, a regional linear regression prediction algorithm based on linear regression is established to support regression vectors. In order to ensure the reliability of the prediction results, the concept of prediction reliability is introduced into the LPSVR algorithm and specific calculation methods are provided. At the same time, it shows that the LPSVR forecasting model outperforms the neural network algorithm in the research of regional economic forecasting. The experimental results of this paper show that the prediction accuracy of Guilin’s annual GDP used by BP neural network is basically lower than that of LPSVR, which is 1.68%. LPSVR has shown good prediction performance in regional economic development prediction.
Regional Tourism Economic Forecasting Model Based on GM Grey Forecasting Method
Authors: Li Bin , Gao Jing
Published: April 2022

On the basis of regional tourism economic development, this paper uses the entropy method and the coupling coordination model to analyse the comprehensive development level and the degree of coupling coordination between tourism and regional development and uses the GM (1, 1) grey prediction model to forecast the degree of coupling coordination between tourism and regional development in China in the next five years, based on the data related to tourism and regional development in China from 1996 to 2015. The results show that the degree of coupling and coordination between tourism and regional development is steadily increasing, with the coupling level moving from low level coupling to antagonistic stage and the coupling coordination level reaching from low level disorder to good level coordination.
The Impact of Artificial Intelligence Technology on Market Public Administration in a Complex Market Environment
Authors: Lu Yu , Gao Xudong
Published: April 2022

Artificial intelligence (AI) technology is applied to various fields and industries with the rapid development of Internet technology. This study aims to promote the intelligent popularization of market public management strategies based on data analysis through the development and promotion of AI. AI technology is used to optimize the integration of the Market Public Administration organizational structure system, and machine algorithms process the data set. A public utility platform management system is established, and a complete public utility management assessment system and platform are based after classifying the data. Research has found that AI technology has been used in the Market Public Administration field to effectively improve work efficiency and solve the duplication and complexity of work in the management process. This has also opened a new chapter for the use of AI technology innovation. The results show that AI technology uses two driving logics of data and algorithms to intelligently solve the management problems and form a complete operating system to reflect the role of AI in the management system.
NSGA-II-Based Microchannel Structure Optimization Problem Study
Authors: Wang Linlin
Published: April 2022

A multiobjective genetic algorithm is used to optimize the structure of circular concave cavities and microchannels. The objective functions of thermal resistance and pumping power are constructed by the response plane approximation method according to the simulation results, and then a mathematical model of multiobjective genetic optimization with the structural parameters of microchannels as variables is established. The Pareto optimized solution sets of thermal resistance and pumping power are calculated by the nondominated ranking genetic algorithm NSGA-II, and the comprehensive heat transfer performance is evaluated by the enhanced heat transfer factor. The results show that the multivariate statistical coefficients

R

2

of the thermal resistance and pumping power objective functions are 0.932 9 and 0.996 6, respectively, indicating the high accuracy of the fitted functions. The optimized channel structure (

e

1

=
0.036.8
 
mm

,

e

2

=
0.019.3
 
mm

) was used to achieve a more uniform temperature field distribution and better integrated heat transfer performance (enhanced heat transfer factor

η
=
1.23

). When the thermal resistance is larger or the pump work is larger, the comprehensive heat transfer effect is not as good as the working condition when the thermal resistance and pump work are more uniform.
Risk Analysis of Distal Metastasis in Chondrosarcoma and the Development and Validation of a Novel Clinical Prediction Model: A Clinical Study Based on the SEER Database
Authors: Li Wenle , Li Rong , Li Wanying , Xu Chan , Ma Minmin , Haiwen Peng  , Wang Bing , Liu Qiang , Yin Chengliang
Published: April 2022

Purpose. Distal metastasis in chondrosarcoma is associated with a poor prognosis. The aim of this study was to develop and validate columnar maps to predict the risk of distal metastasis in patients with chondrosarcoma, thereby contributing to clinical diagnosis and treatment. Methods. Data from chondrosarcoma patients obtained from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2016 were then screened by univariate and multifactorial logistic regressions to construct a predictive distal metastasis risk. The model discrimination of nomogram was assessed by calibration plots, while the predictive accuracy and clinical values were measured by decision curve analysis (DCA). In addition, predictive column line plots were validated in an in-house test set. Results. A total of 1,290 patients were included and randomized in a 7 to 3 ratio into a training group (n = 906) and a test group (n = 384). After logistic regression analysis, the significant variables were gender, tumor pathological grade, laterality, primary tumor stage, regional lymph node metastasis, surgical treatment, and chemotherapy. Calibration curves showed agreement between column line graph predictions and actual observations, while DCA showed the clinical utility of the nomogram. In addition, ROC showed good discrimination and calibration in the training (AUC = 0.937, 95% CI 0.919–0.952) and validation groups (AUC = 0.91, 95% CI 0.877–0.937). Conclusions. The nomogram for distal metastasis risk in patients with chondrosarcoma can effectively predict the individualized risk of distal metastasis and provide clinicians with enlightening information to optimize treatment options.
Information Processing Methods and LOT Cloud Platform for Fusion of 5G Urban Component Sensors
Authors: He Jing
Published: April 2022

With the rapid development of intelligent applications, the development of the Internet of Things changes with each passing day. The Internet of Things, as an essential component of the new information technology, has already become another revolutionary information industry after computers and modern communications. Although the Internet of Things has developed and grown, at the application level, the applications of Internet of Things devices of different architectures are relatively independent of their data information. This paper is based on the research of 5G urban component sensor information processing method and LOT cloud platform, and proposes a data fusion algorithm based on the data sequence of the same time. It analyzes the system process and architecture diagram of the LOT cloud platform, examines the performance of the Hadoop platform on different scale data sets, and uses the stand-alone system as a reference. The experimental results show that the time increase of the cluster decreases with the increase of the amount of data, which shows that the system exerts the advantages of parallel computing under the massive amount of data, and as the data source file increases, the accuracy rate decreases. When the data source size is 2000 MB, the Hadoop cluster system with 3 and 4 cluster nodes has the highest accuracy, 79.21% and 76.28%, respectively.
A Preliminary Study on the Use of Rice Husk-Based Smoke Powder for Meatball Preservatives
Authors: Faisal Muhammad , Desvita Hera , Abubakar Yusya , Azwar
Published: April 2022

This study examines the use of smoke powder derived from rice husks as a preservative for chicken meatballs. Rice husks were pyrolyzed in a slow pyrolysis reactor at the temperatures of 300°C (T1), 350°C (T2), and 400°C (T3) to produce liquid smoke. Each of the liquid smoke was distilled at 190°C and then converted into smoke powder by spray drying method. The smoke powder’s feasibility as a meatball preservative was examined by total plate count (TPC), total volatile base (TVB), most probable number (MPN) test of E. coli, and organoleptic (aroma, texture, and color) tests. The results showed that the TPC and TVB increased with storage time. At the storage time of 76 hours, the meatballs were no longer suitable for consumption as the TPC had exceeded the minimum limit. In meatballs with T3 smoke powder at 72-hour storage, the number of colonies was 6.87 × 104 CFU/g, indicating the TPC value has not exceeded the threshold yet. The TVB test showed that up to 72 hours of storage, the meatballs remained fresh with a TVB value of less than 0.20 mgN/g. The result of the organoleptic test also showed that meatballs could last for 72 hours. The MPN test, on the other hand, revealed that the E. coli was still permissible after 68 hours of preservation.
New Paradigm in Cell Therapy Using Sperm Head to Restore Brain Function and Structure in Animal Model of Alzheimer’s Disease: Support for Boosting Constructive Inflammation vs. Anti-Inflammatory Approach
Authors: Pakravan Nafiseh , Abbasi Ardeshir , Hassan Zuhair Mohammad
Published: April 2022

Alzheimer’s is characterized by accumulation of amyloid-β (Aβ) associated with insufficient clearance of toxicants from the brain establishing a chronic inflammation and other abnormalities in the brain. Inflammatory microglia and astrocytes along with abnormal lymphatics associated with insufficient clearance of Aβ and other toxicants from the brain establish a chronic inflammation. This causes abnormal choroid plexus, leukocyte trafficking, and hypoxic condition along with high levels of regulatory T cells (Tregs). There is no consensus among researchers regarding decreasing or increasing Tregs to achieve therapeutic effects. Different opposing studies tried to suppress or boost inflammation to treat AD. Based on reproductive immunology, sperm induces constructive inflammatory response and seminal-vesicle-fluid (SVF) suppresses inflammation leading to uterus remodeling. It prompted us to compare therapeutic efficiency of inflammatory or anti-inflammatory approaches in AD model based on reproductive immunology. To do so, SVF, sperm, or sperm head (from Wistar rat) was administered via intra-cerebro-ventricular route to Sprague Dawley rat AD model. Behavioral and histological examination were made and treatment groups were compared with control AD model and normal groups. Therapeutic efficacy was in the order of sperm head>sperm>SVF. Sperm head returned learning memory, Aβ, lymphatics, neural growth factors, choroid plexus function, Iba-1/GFAP, MHC II/CD86/CD40, CD38/IL-10, and hypoxia levels back to normal level. However, SVF just partially ameliorated the disease. Immunologic properties of sperm/sperm head to elicit constructive inflammation can be extended to organs other than reproductive. This nature-based approach overcomes genetic difference as an important obstacle and limitation in cell therapy, and is expected to be safe or with least side effects.
A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors
Authors: Choudhury Atish D. , Higano Celestia S. , de Bono Johann S. , Cook Natalie , Rathkopf Dana E. , Wisinski Kari B. , Martin-Liberal Juan , Linch Mark , Heath Elisabeth I. , Baird Richard D. , García-Carbacho Javier , Quintela-Fandino Miguel , Barry Simon T. , de Bruin Elza C. , Colebrook Steve , Hawkins George , Klinowska Teresa , Maroj Brijesh , Moorthy Ganesh , Mortimer Peter G. , Moschetta Michele , Nikolaou Myria , Sainsbury Liz , Shapiro Geoffrey I. , Siu Lillian L. , Hansen Aaron R.
Published: April 2022

Purpose:

To characterize safety and tolerability of the selective PI3Kβ inhibitor AZD8186, identify a recommended phase II dose (RP2D), and assess preliminary efficacy in combination with abiraterone acetate or vistusertib.

Patients and Methods:

This phase I open-label study included patients with advanced solid tumors, particularly prostate cancer, triple-negative breast cancer, and squamous non–small cell lung cancer. The study comprised four arms: (i) AZD8186 monotherapy dose finding; (ii) monotherapy dose expansion; (iii) AZD8186/abiraterone acetate (with prednisone); and (iv) AZD8186/vistusertib. The primary endpoints were safety, tolerability, and identification of the RP2D of AZD8186 monotherapy and in combination. Secondary endpoints included pharmacokinetics (PK), pharmacodynamics, and tumor and prostate-specific antigen (PSA) responses.

Results:

In total, 161 patients were enrolled. AZD8186 was well tolerated across all study arms, the most common adverse events being gastrointestinal symptoms. In the monotherapy dose-finding arm, four patients experienced dose-limiting toxicities (mainly rash). AZD8186 doses of 60-mg twice daily [BID; 5 days on, 2 days off (5:2)] and 120-mg BID (continuous and 5:2 dosing) were taken into subsequent arms. The PKs of AZD8186 were dose proportional, without interactions with abiraterone acetate or vistusertib, and target inhibition was observed in plasma and tumor tissue. Monotherapy and combination therapy showed preliminary evidence of limited antitumor activity by imaging and, in prostate cancer, PSA reduction.

Conclusions:

AZD8186 monotherapy had an acceptable safety and tolerability profile, and combination with abiraterone acetate/prednisone or vistusertib was also tolerated. There was preliminary evidence of antitumor activity, meriting further exploration of AZD8186 in subsequent studies in PI3Kβ pathway–dependent cancers.
Rebobinando a fita: arqueologia do videotape nas aldeias
Authors: Belisário Bernard
Published: April 2022

O artigo retoma algumas das experiências, movimentos e processos de aprendizagem e produção com o videotape junto a comunidades indígenas no Brasil, quando o equipamento de gravação em fita magnética começava a se popularizar com os formatos portáteis. O cineasta Andrea Tonacci se inquieta com as possibilidades do registro e reprodução simultâneas do videotape como parte da figuração da comunidade, como olhar processual, reflexivo. As camcorders dos Kayapó registraram discursos, viagens, eventos e rituais comunitários, antes mesmo das primeiras experiências do Vídeo nas Aldeias (VNA). O filme A festa da moça (1987), de Vincent Carelli, opera uma alteração naquilo que era imaginado como “olhar do outro” por Tonacci – e por muitas das produções do Vídeo Popular –, pois nos devolve um olhar deslocado, que presencia a retomada dos corpos dos jovens em comunidade, enfeitados e marcados como os antepassados, ao mesmo tempo que nos posiciona como espectadores não indígenas.
Black Wadada: dreadlocks, barbas e anticolonialismo entre homens rastafari na Jamaica
Authors: Araujo Felipe Neis
Published: April 2022

Neste ensaio eu analiso as políticas articuladas a duas práticas corporais observadas por grande parte dos homens rastafari jamaicanos: o cultivo de dreadlocks e barbas. Começo pela história política dos dreadlocks e barbas, mostrando como eles foram conectados a noções de africanismo e à vida social dos textos bíblicos no Movimento Rastafari. Eu argumento que estes modos de cuidado com o corpo traduzem políticas anticoloniais rastafari que visam desafiar e criticar estéticas e modos de existência coloniais e pós-coloniais na ilha caribenha, o que dá ensejo a reflexões sobre pertencimento, soberania e africanidade diaspórica.
A quilombola e o vaqueiro
Authors: Maciel Filipe de Oliveira , Carvalho Marivaldo Aparecido de
Published: April 2022

A obra de arte “A Quilombola e o Vaqueiro” (Pintura, óleo sobre tela, 50 x 50 cm. Peçanha, Minas Gerais – Brasil. Março 2021), junto de seu poema, nasce do trabalho de campo etnográfico, em execução, da pesquisa “O Processo de Identidade das Comunidades Quilombolas de Peçanha, Minas Gerais: História Oral, Cultura e Etnicidade”. Esta pesquisa é realizada no PPGER/UFVJM, com apoio da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES). A obra constitui-se em um processo de transformação performática do diário de campo em artes plásticas, como revelação de resultados preliminares desta pesquisa, que encontra na terra, espiritualidade e violência os principais mecanismos de estruturação identitária nestes quilombos. Trata-se de um mecanismo de expressão de linguagens, códigos, ritualísticas, trajetórias histórica, saberes ancestrais e relações dialéticas vivenciadas etnograficamente pelo corpo-alma-pesquisador, objetivando a expressão do não-dizível e a contribuição para outras dimensões da produção da ciência antropológica.
Fotografia ritual: uma experiência com o povo Huni Kuin
Authors: Milano Barbara
Published: April 2022

A investigação do rito como objeto fotografável e da fotografia em si como um rito a partir do gesto performativo de fotografar são os norteadores deste trabalho. Fruto de uma experiência de imersão junto ao povo Huni Kuin em 2017, e o desenvolvimento de um trabalho fotográfico realizado em circunstâncias cerimoniais com uso das plantas de poder amazônicas, o texto/contação “Fotografia Ritual: Uma experiência com o povo Huni Kuin”.
Contato entre mundos: desenhos produzidos durante ritual ecumênico com plantas medicinais na Arca da Montanha Azul
Authors: Romanoff do Vale Frederico
Published: April 2022

O artigo faz uma descrição etnográfica sintética, buscando explicitar os princípios do grupo Arca da Montanha Azul e a produção de desenhos realizada durante ritual ecumênico com plantas medicinais, prática inovadora quando comparada a outras casas semelhantes. Para tanto, o artigo contextualiza o espaço segundo seu aspecto social e político, faz uma explicação do processo ritual, do processo iniciático, sobre o conceito de cura e traz alguns trechos de entrevistas realizadas com praticantes da casa que falam sobre sua relação com os desenhos. Encerra-se o texto apresentando argumento a respeito do caráter agentivo presente nos desenhos produzidos durante as cerimônias.
Fotografia-chave para compreensão possível do hijab
Authors: Molina Ana Maria Ricci
Published: April 2022

Este artigo trata de uma foto do álbum Prostitute (1975-1977), de Kaveh Golestan, a qual é apresentada como uma fotografia-chave, aquela capaz de gerar um exercício do olhar, e que possibilitou uma compreensão a respeito do véu islâmico, dado pela cobertura do corpo como razão inicial seguida por suas variações no modo de uso. Acrescentam-se a essas variações a pose da mulher prostituta com o véu a representar a subversão (em ambiente anti-islâmico) e a transgressão (pela dessacralização do corpo), fabricada pelo fotógrafo com a fotografada em relação ao seu lugar na comunidade, como exercício da crítica.
Abstract 004: Racial And Ethnic Differences In Cardiac Rehabilitation Participation: Effect Modification By Household Income
Authors: Garfein Joshua , Guhl Emily , Swabe Gretchen , Sekikawa Akira , Barinas-Mitchell Emma , Forman Daniel E , Magnani Jared W
Published: April 2022

Introduction:
Cardiac rehabilitation (CR) is associated with improved cardiovascular outcomes. Participation remains low, particularly in individuals of non-white race. It remains unclear how household income influences racial/ethnic differences in CR participation. We evaluated (1) differences in CR participation by race/ethnicity in a contemporary sample of insured US adults and (2) assessed how household income modifies associations between race/ethnicity and CR participation.

Hypothesis:
We hypothesized that individuals of non-white race/ethnicity would have lower participation than those of white race, but that the difference would be attenuated by higher annual household income.

Methods:
We identified 107,199 individuals with a CR-qualifying diagnosis between 1/1/2016 and 12/31/2018 in Optum’s de-identified Clinformatics® database. We evaluated associations between race/ethnicity and participation in CR, and assessed interaction between race/ethnicity and annual household income.

Results:
The mean±SD age of all participants was 70.4±11.6 years; 37.4% were female and 76.0% were white race. Overall, 28,443 (26.5%) attended ≥1 CR sessions. After adjustment, compared to white individuals, the odds of attending CR was 45% lower for Asian individuals [95% confidence interval (CI): 39%, 50%], 26% lower for Black individuals (95% CI: 22%, 30%), and 54% lower for Hispanic individuals (95% CI: 51%, 56%), all
P
<0.0001. The time to CR attendance was also significantly longer for all non-white individuals. Associations between race/ethnicity and attendance at CR differed significantly across household income categories (
P
, interaction=0.0005); however, non-white individuals were less likely to attend CR at all incomes.

Conclusion:
In a geographically and racially diverse cohort, participation in CR was low, especially among non-white candidates. Household income may impact the link between race/ethnicity and attendance at CR, but substantial racial and ethnic disparities exist across incomes.
Abstract 006: Neighbourhood Deprivation And Morbid Obesity: Insights From Houston Methodist Outpatient Learning Health System Registry
Authors: nwana nwabunie , Taha Mohamad , GULLAPELLI RAKESH , Nicolas Charlie , Jones Stephen , Khan Safi U , Javed Zulqarnain , Satish Priyanka , Mahajan Shivani , Cainzos Achirica Miguel , Nasir Khurram
Published: April 2022

Introduction:
Area Deprivation Index (ADI), a proxy measure for neighbourhood socioeconomic context, is informative for prioritizing limited resources in improving health outcomes. With emerging therapeutic options to improve cardiometabolic health among individuals with morbid obesity, whether available measures, such as ADI, for integrated health systems can identify this subpopulation at risk is unknown.

Methods:
This cross-sectional study analyzed data from 865,995 adult patients in the Houston Methodist Outpatient Learning Health System Registry between June 1
st
, 2016 and July 20
th
, 2021. Using University of Wisconsin-Madison School of Medicine’s ADI dataset, each patient was assigned an ADI rank according to the census block group of their geocoded residential address. BMI was calculated based on recorded height and weight. Patients with non-geocoded addresses (n=9 855), missing and abnormal BMI values (n=107 037) were excluded. Multinomial logistic regression models were used to examine the association between ADI and morbid obesity (BMI≥40 kg/m
2
).

Results:
A total of 751,174 adults with an ADI ranking were included in the analysis. Overall, the prevalence of morbid obesity was 6.9% (n=51,609). The age-adjusted prevalence of morbid obesity increased across worsening neighborhood deprivation in overall population and across racial/ethnic subgroups (Figure 1). Each ADI rank increase in neighborhood disadvantage was associated with an unadjusted odds ratio (OR) of 1.022 (95% CI, 1.022-1.023) for morbid obesity compared to normal weight. After adjusting for age, sex and race/ethnicity, we found a statistically significant association of worst vs least level of neighborhood deprivation with patients with morbid obesity compared to normal weight (aOR, 3.75; 95% CI, 3.60-3.89).

Conclusion:
The study highlights utility of census-based measures to identify patients living in socioeconomically deprived areas for comprehensive morbid obesity management strategies.
Abstract 013: Metabolomic Profiles And Ideal Cardiovascular Health: Insights From The Framingham Heart Study (fhs)
Authors: Li Yi , Gray Ayana R , Xue Liying , Andersson Charlotte , Ko Darae , Benjamin Emelia J , Levy Daniel , Vasan Ramachandran S , Larson Martin , Rong Jian , Liu Chunyu , Xanthakis Vanessa , Fetterman Jessica L , Gopal Deepa M
Published: April 2022

Introduction:
The American Heart Association’s framework “ideal cardiovascular health” (CVH) focuses on modifiable risk factors to reduce the overall burden of cardiovascular disease (CVD). Metabolomics provide important pathobiological insights into risk factors and CVD development. Whether circulating metabolites relate to CVH status and mediate the relations of CVH score with atrial fibrillation (AF) and heart failure (HF) has not been explored.

Hypothesis:
We hypothesized: a) CVH score associates with metabolites; and b) metabolites mediate the relation of CVH score with incident AF and HF.

Methods and Results:
We analyzed 3056 adults (mean age 54 years; 54% women) in FHS Offspring Cohort (Exam 5); 2059 participants had metabolomics data. Each metabolite measurement was log transformed and standardized for data normalization. Using linear mixed models, CVH score was associated with 144 metabolites (false discovery rate, q-value < 0.05), adjusting for age, sex, estimated glomerular filtration rate (eGFR) and family structure. Of these 144 metabolites, 65 metabolites overlapped with key cardiometabolic components of the CVH score (body mass index, blood pressure, and fasting blood sugar). In mediation analyses (adjusting for age, sex, eGFR), no metabolites mediated the relation between CVH score and incident AF. However, 11 metabolites (C36:4 phosphatidylcholine, isocitrate, glycerol, ornithine, aminoadipate, 3-indolepropionic acid, cystathionine, asparagine, alpha-hydroxybutyrate, phosphorylated saccharides, and C52:5 triacylglycerol) partially mediated the association between CVH score and incident HF in multivariable-adjusted models.

Conclusion:
Multiple metabolites associate with the CVH score and many of the metabolites are specifically associated with the cardiometabolic components of the CVH score. Several metabolic signatures, particularly lipids and tricarboxylic acid cycle intermediates, partially mediated the relation between CVH score and incident HF. Our findings lend insight into the role of metabolites in the relations of modifiable cardiovascular risk factors with incident HF.
Abstract 025: Radon Exposure And Incident Stroke Risk In The Women’s Health Initiative
Authors: Buchheit Sophie F , Collins Jason M , Anthony Kurtis , Love Shelly-ann M , Stewart James , Gondalia Rahul , Manson Joann E , Reiner Alex P , Schwartz Gary , Vitolins Mara , Schumann R R , Smith Richard , Whitsel Eric A
Published: April 2022

Background:
Although the role of radon gas in lung carcinogenesis is well-known, relatively little is known about radon’s role in the pathogenesis or epidemiology of cerebrovascular disease.

Methods:
We therefore identified postmenopausal women without a history of stroke at the 1993-1998 screening visit of the Women’s Health Initiative Clinical Trials and Observational Study (WHI CT and OS). We linked their geocoded addresses to U.S. Environmental Protection Agency (EPA)-predicted, county-level, indoor, screening radon gas concentrations classified as follows: Zone 3 (<2 pCi/L), Zone 2 (2-4 pCi/L), and Zone 1 (>4 pCi/L). We identified incident strokes based on physician-reviewed, classified, and adjudicated medical records. We measured time from screening to the earliest stroke or censoring date (02/28/20). We used Cox proportional hazards models to estimate radon-related risk of stroke on an attained-age scale as a hazard ratio (HR) and 95% confidence interval (CI), adjusting for WHI design, race/ethnicity, education, homemaker status, U.S. Census region, neighborhood socioeconomic status, smoking, alcohol intake, sodium intake (g/day), 2005 Healthy Eating Index, recreational physical activity (MET-hr/wk), body mass index (kg/m
2
), systolic blood pressure (mm Hg), as well as history of diabetes, hypercholesterolemia, atrial fibrillation, and deep vein thrombosis/pulmonary embolism.

Results:
Among 158,906 women (mean, standard deviation [SD] age = 63.1 [7.2] years; 83% white; 9% black; 4% Hispanic; 4% other), we identified 6,979 incident strokes over a mean [SD] follow-up period of 9.3 [5.6] person-years, i.e. 3.41 strokes / 1,000 person-years. The proportion of women with incident stroke was 1.38%, 1.72%, and 1.30% in EPA Radon Zones 3, 2, and 1, respectively. Corresponding incidence rates by EPA Radon Zone were 3.33, 3.43 and 3.49 per 1,000 person-years. Relative to women in Zone 3, those in Zones 2 and 1 had higher adjusted risks of incident stroke: HR (95% CI) = 1.07 (1.00, 1.14) and 1.15 (1.07
,
1.24).

Conclusion:
Radon gas is a pervasive carcinogen that also may increase susceptibility to a societally burdensome form of cerebrovascular disease, thereby highlighting the potential value of targeted testing, radon-safe construction, and mitigation in stroke prevention.
Abstract 026: Rurality And Incident Heart Failure Risk In The Southern Community Cohort Study
Authors: Turecamo Sarah , Xu Meng , Joo Jungnam , Dixon Debra , Gupta Deepak K , Lipworth Loren , Roger Veronique L
Published: April 2022

Background:
Rural-urban disparities in cardiovascular mortality are increasing, with higher heart failure (HF) mortality among rural residents. Whether rurality is also associated with an increased risk of HF incidence is not known.

Methods:
A total of 27,119 Southern Community Cohort Study participants without prevalent HF receiving Centers for Medicare and Medicaid Services (CMS) at cohort enrollment (2002-2009) were included. Rurality at enrollment was classified by Rural-Urban Commuting Area codes based on participant census tract. Incident HF was defined using ICD 9/10 codes (428.x, I50x) via CMS linkage through 2016. The association between rurality and incident HF was tested in Cox models adjusted for age, sex, race, socioeconomic status, cardiovascular risk factors and comorbidities, with addition of a race-sex by rurality interaction term.

Results:
Overall, 20% (5,556) of participants resided in rural areas. Compared with urban-residing participants, individuals in rural areas were more likely to be older, female, married, less educated, and to have a higher burden of traditional cardiovascular risk factors, but were of similar race and income. Over median 13-years follow-up, 1,865 (33.6%) and 5,677 (26.3%) rural and urban individuals developed HF, respectively; p < 0.001. In adjusted analysis, rurality associated with a 19% greater risk of incident HF (HR 1.19, 95% CI 1.12-1.26). The association between rurality and HF risk varied by race-sex (p-interaction = 0.003), with a marked disparity between Black (HR 1.34, 95% CI 1.19-1.50) and white (HR 0.98, 95% CI 0.82-1.17) men (Figure).

Conclusions:
In this large biracial Southeastern US population, rural residence associated with a substantial excess risk of HF particularly for women and Black men. These disparities highlight need for further research into underlying determinants and public health interventions.
Abstract 046: Remission Of Prediabetes In Middle-age And Risk Of Long-term Complications
Authors: Wallace Amelia S , Rooney Mary R , Echouffo Tcheugui Justin , Grams Morgan , Selvin Elizabeth
Published: April 2022

Background:
Prediabetes identifies people at high risk for diabetes and future cardiometabolic disease. It is unclear if remission of prediabetes is associated with better outcomes.

Methods:
We conducted a prospective cohort study of 7506 participants without diabetes who attended visit 2 (V2, 1990-1992) and visit 4 (V4, 1996-1998) of the Atherosclerosis Risk in Communities (ARIC) Study. We used Cox models to compare risk of mortality, incident diabetes, and cardiovascular and kidney disease over median 21.2 years of follow-up. Participants were classified by glycemia at V2 and V4 - stable normoglycemia: fasting glucose (FG) <100mg/dL at both visits; remission of prediabetes: FG 100-125 mg/dL at V2 and FG <100 mg/dL at V4; progression to prediabetes: FG <100 mg/dL at V2 and FG 100-125 mg/dL at V4; and persistent prediabetes: FG 100-125 mg/dL at both visits. Analyses were adjusted for demographics and cardiometabolic risk factors.

Results:
There were 4064 (54%) participants (mean age: 56 years; 65% female; 12% black) with stable normoglycemia, 1149 (15%) participants (mean age: 57 years; 52% female; 18% black) with remission of prediabetes at V4, and 1511 (20%) participants (mean age: 57 years; 43% female; 20% black) with persistent prediabetes. As compared to participants with stable normoglycemia, participants with remission of prediabetes had higher risk of incident diabetes (HR 95%CI 1.71, 1.49-1.98), but no other outcomes. Participants with persistent prediabetes had increased risk of all outcomes, including mortality (HR 95%CI 1.13, 1.03-1.24), and incident diabetes (HR 95% CI 3.24, 2.88-3.65) (
Table
).

Conclusions:
Persistent prediabetes over 6 years in middle age was associated with increased risk of mortality and cardiometabolic disease as compared to stable normoglycemia. People with remission of prediabetes had increased risk of diabetes, but no increased risk of long-term clinical outcomes. Repeat measures of glycemia in middle age could improve risk-stratification for future cardiometabolic disease.
Abstract 053: Heals Med-Tech: A Telehealth Based Behavioral Lifestyle Hypertension Control Program For High-risk African Americans Presenting At Primary Care Clinics
Authors: Clarke Amanda W , EL Moudden Ismail , Newby Olivia M , Wood LaWanda , Dodani Sunita
Published: April 2022

Background:
Hypertension (HTN) related disparities have been recognized for decades among African-Americans(AAs), particularly concerning HTN control, HTN awareness, and HTN compliance, particularly among AA women.The efficacy tested HEALS Med-Tech behavioral lifestyle program offers a promising solution. We present thefindings from the first 3 months of HEALS Med-Tech intervention on BP reduction and improvement in DASH dietand exercise. Primary outcomes of interest are changes in BP, while secondary outcomes include a change in BMIand waist circumference.

Methods:
HEALS Med-Tech program offers 3 components:
a)
HEALS
(
He
althy
Ea
ting and
Li
ving
Sp
iritually) a 12-month behavioral lifestyle intervention, modified from the DASH and PREMIER programs (3-mo interventionfollowed by 9-mos of maintenance);
b)
Med
-component provides HTN management through medications and socialsupport provided by PCP and Community Health Ambassadors; and
c)
Tech
-component provides interactivetelehealth by mobile phone to combat barriers to healthcare access. The results were analyzed using ANOVA andregression analysis. Dietary analysis was done to obtain DASH scores from the food diaries and 24-hr dietary recalls.The program is currently in month 6 of its maintenance phase.

Results:
A total of 62 AA participants were enrolled and randomized to either HEALS Med-Tech or standard care(control). At the end of 3 months, HEALS Med-Tech arm showed a significant reduction in SBP (13.11 mmHg; p=0.01)and DBP (4.2 mmHg; p=0.04) compared to the standard care arm (SBP and DBP change of 7.83 mmHg and 0.32mmHg), respectively. After 12 weeks of intervention, the average DASH scores were 2.002 for HEALS and 1.592 forcontrol arm compared to 1.620 and 1.500 at baseline for HEALS and control arm, respectively.

Conclusion:
A multidisciplinary, community-engaged approach with telehealth component for improved access tohealthcare may be useful in fostering the acceptability of behavior change interventions among marginalized AAs.
Abstract 068: Investigation Of Familial Hypercholesterolemia Subtypes In The UK Biobank
Authors: Berry Alexander S , Jones Laney , Sturm Amy C , Gidding Samuel , Oetjens Matthew T
Published: April 2022

Familial hypercholesterolemia (FH) is an inherited disorder characterized by lifelong elevated low density lipoprotein cholesterol (LDL-C) and dramatically increased risk for premature atherosclerotic cardiovascular disease (ASCVD). FH diagnosis currently requires either the presence of a pathogenic variant in an FH gene, or phenotypic characteristics. However, genetic studies now suggest that FH encompasses four discrete subtypes: 1) presence of a monogenic FH variant, 2) a high LDL-C polygenic score, “polygenic FH,” 3) elevated lipoprotein(a), and 4) LDL-C
>
190 mg/dl and a positive family history without an identifiable genetic cause, or true “phenotypic FH.” Here, we screened 134,444 unrelated white British individuals with exome sequences available in the UK Biobank for individuals with FH subtypes. We classified 358 individuals (1 in 376; 0.27%) with a pathogenic variant in their exome sequence as monogenic FH, 2,800 had polygenic FH (1 in 48; 2.1%), 2,246 had elevated lipoprotein (a) (1 in 60; 1.7%), and 3,146 had phenotypic FH (1 in 43; 2.3%). The remaining 125,894 samples without an FH subtype were classified as controls. We stratified the cohort into statin treated and untreated individuals. Those with an FH subtype were 2.8 times more likely to be prescribed a lipid lowering medication at the baseline interview compared to controls. In the statin treated group (n=21,875), those with monogenic FH were at the highest risk for 10-year incident ASCVD. We observed a 2.7 (95% confidence interval (95% CI): 1.6-4.3) fold higher ASCVD risk in monogenic FH compared to controls as measured by the hazard ratio (HR). Those with elevated lipoprotein (a) and phenotypic FH were also at increased risk for ASCVD (HR = 1.5 (95% CI: 1.1-2.1) and HR = 1.6 (95% CI: 1.3-2.1), respectively). In contrast, we do not observe elevated rates of incident ASCVD in those with polygenic FH relative to controls among treated individuals. In the untreated group (n=112,569), the risk of ASCVD in FH subtypes was more pronounced relative to controls. Individuals with elevated lipoprotein (a) were at the highest risk of incident ASCVD (HR = 2.9, 95% CI: 2.4-3.7) among the four subgroups. In conclusion, we observed differences in ASCVD risk among subtypes of FH. These findings demonstrate the importance of considering subtypes in ASCVD risk assessment for patients who present with the FH phenotype.
Abstract 069: Missed Opportunities For The Control Of Hypertension In Premenopausal Women In The US
Authors: Hennessy Susan , Penko Joanne , Coxson Pamela , Wei Pengxiao , Atum Azuka , Boylan Ross , Bibbins-Domingo Kirsten
Published: April 2022

Background:
Cardiovascular disease (CVD) is the number one killer in US women, and hypertension the most common modifiable risk factor. Though women have had better control of hypertension than men, control rates have declined over the past decade. We quantify US population estimates of missed opportunities for hypertension control in premenopausal women with access to regular healthcare.

Methods:
We used National Health and Nutrition Examination Survey (2011-2018) to identify US women aged 35-54 years with no prior CVD. Within this sample we identified the population prevalence of respondents with hypertension (SBP ≥ 140mmHg or DBP ≥ 90mmHg), a usual healthcare provider, attending at least two visits per year, awareness (ever been told you have hypertension), treatment (prescribed and taking hypertension medication) and control (SBP < 140mmHg) of blood pressure. We derived hypertension control cascades for this population comparing 2011-2014 and 2015-2018.

Results:
The prevalence of hypertension in women age 35-54 years with no prior CVD was 6.4M in 2011-2014 and rose to 8.5M in 2015-2018. The prevalence at each stage and the missed opportunities to intervene are presented in the hypertension control cascade (Figure 1). In 2015-2018 only two thirds of this population had access to regular healthcare. Among the women with hypertension in regular care, the greatest missed opportunity occurred in those who are unaware of their hypertension (25%), followed by those untreated (11%) and uncontrolled (6%).

Conclusion:
The number of premenopausal women with hypertension in the US increased by 25% from the start to the finish of the prior decade. Although most of these 2.1 million women are cared for by healthcare professionals, considerable gaps exist in awareness, treatment, and control of their hypertension, gaps that have not improved substantially over the decade. Improvements in hypertension prevention, access to care, and delivery of guideline-concordant care for premenopausal women should be a priority.
Abstract 070: Area Deprivation Index Is Associated With Oral Anticoagulation Provision In Incident Atrial Fibrillation
Authors: Omole Toluwa D , Garrard William , Mulukutla Suresh R , Thoma Floyd W , Zhu Jianhui , Magnani Jared W
Published: April 2022

Introduction:
Oral anticoagulation (OAC) is a standard of care for stroke prevention in individuals with atrial fibrillation (AF). Social determinants of health have had limited investigation in AF and particularly in relation to OAC. We examined the effect of area deprivation index (ADI) on OAC prescription and agent selection (warfarin or direct-acting OAC).

Hypotheses:
(1) Individuals with AF living in neighborhoods with higher ADI (i.e., higher deprivation), are less likely to receive OAC for stroke prevention than those living in neighborhoods with lower ADI. (2) Among those prescribed OAC, those living in neighborhoods with higher ADI are more likely to receive warfarin as opposed to direct OAC.

Methods:
We conducted a retrospective analysis of patients with incident, non-valvular AF from 2015-2020 receiving care at a large, regional health center. We extracted demographics, medications, and problem lists and used administrative coding to identify comorbid conditions and relevant covariates, and the Zip+4 to ascertain ADI. We examined the relation between ADI and OAC prescription and selection at 90 days following the AF diagnosis in multivariable-adjusted models.

Results:
Following exclusions, the dataset included 20,210 individuals (age 74.5±10.9 years; 51% (10,270 of 20,210) women; 94% (19,053 of 20,210) white race. Individuals in the highest quartile of ADI were 13% less likely to receive OAC than those in the lowest quartile (adjusted Odds Ratio [OR] 0.87; 95% Confidence Interval [CI], 0.77-0.98) at 90 days following AF diagnosis. In those receiving OAC, individuals in the highest quartile of ADI were 21% less likely to receive a more modern direct-acting OAC as opposed to warfarin compared to those in the lowest quartile (aOR 0.79; 95% CI, 0.63-0.99) at 90 days following AF diagnosis.

Conclusions:
We demonstrate the association of ADI with (1) access to OAC for stroke prevention in AF and (2) likelihood of treatment with a more contemporary direct-acting OAC (rather than warfarin). Our results suggest health inequities in the provision of anticoagulation for stroke prevention in AF in a large, regional health care system.