bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of perceived organizational support on the prohibitive voice behavior of knowledgeable talents during the COVID-19 pandemic: Exploring moderating role of the digitalization level
Authors: Chen Xiao , Ren Kangjun , Shen Yan
Published: November 2022

This study focuses on the effect of perceived organizational support on the prohibitive voice of knowledgeable talents and on the factors influencing that voice during the COVID-19 pandemic in China. Grounding our research in social exchange theory and the Chinese sociocultural background, we collected data from 714 questionnaires from universities in Zhejiang Province and analysize by linear regression and found, first, that perceived organizational support significantly increased the prohibitive voice of knowledgeable talents and, second, that in the relationship between perceived organizational support and the prohibitive voice of those talents, the level of digitalization level of an organization has a positive the effect of perceived organizational support on prohibitive voice behavior. This study enriches the theory of voice behavior, helps universities understand the behavioral patterns of knowledgeable talents and guides the cultivation of an atmosphere with prohibitive voice behavior.
Developments in early adolescents’ self-regulation: The importance of teachers’ supportive vs. undermining behavior
Authors: Opdenakker Marie-Christine
Published: November 2022

Research has established that the ability to self-regulate is an important factor in adolescents’ learning, and cognitive and social functioning. Several theories on self-regulation and classroom studies suggest effects of the social learning environment on students’ self-regulation. However, most studies investigating these relations have a cross-sectional correlational design and do not relate to adolescents, resulting in little knowledge about causal directions and adolescents. This study extends existing research by examining effects of a selection of supportive and undermining teacher behavior dimensions on early adolescents’ development of self-regulation (self-regulated learning). The teacher behavior dimensions are based on ideas of the self-determination theory in which a distinction is made between dimensions that support vs. thwart three basic psychological needs (need for autonomy, competence, and relatedness) which are assumed to be important for human growth and (psychological) well-functioning. Supporting autonomy, delivering structure, and being involved with the students are assumed to be important for the fulfillment of students’ basic psychological needs, while exhibiting controlling instructional behavior, having chaos, uncertainty and inconsistency in the classroom, and rejection and neglect of students, are supposed to be a treat. Questionnaires were used for measuring students’ perceptions of their teachers’ behavior and their own self-regulation at several points in time during their first year of secondary education. Participants in the study were 566 students belonging to 20 Mathematics/English grade-7 secondary education classes in The Netherlands. Multilevel analyses point to the importance of all three teacher need-supportive dimensions (with highest effects of structure and involvement) and indicated that teachers’ need-thwarting behavior negatively affected students’ self-regulation. However, when corresponding supportive and thwarting teacher behavior dimensions were included together in the same multilevel model, only the effect of the undermining dimension of controlling teacher behavior remained significant in addition to the corresponding autonomy-support dimension. Findings are in line with existing research and highlight the importance of both teachers’ need-supportive and teachers’ need-thwarting behavior in daily secondary-education classrooms and contribute to deepen our insight in and understanding of factors (related to external regulation by teachers) leading to positive and negative developments of early adolescents’ self-regulation, and, in particular, their self-regulated learning.
Antecedents and consequences of brand experience in virtual sports brand communities: A value co-creation perspective
Authors: Zhuo Jin-Yuan , Su Rong-Hai , Yang Hsi-Hsun , Hsu Mao-Chou
Published: November 2022

The influence mechanism for brand experience in virtual sports brand communities is the subject of many studies, but these studies do not feature a holistic consideration of antecedents and consequences, and the moderating role of brand attachment is unclear. Drawing on the value co-creation theory, this study determines the impact of brand experience and its mechanism using the data from 508 virtual sports brand communities. The empirical test results show that value co-creation (i.e., corporate-initiated value co-creation and customer-initiated value co-creation) has a positive effect on the brand experience and that the brand experience has a positive effect on the purchase intention. Brand attachment does not have a moderating role between brand experience and purchase intention so as the degree of brand attachment increases, the brand experience does not increase the purchase intention through a brand attachment. This study determines the antecedents and consequences of brand experience in virtual sports brand communities from a value co-creation perspective, to determine the impact and mechanisms of virtual sports brand communities to guide the marketing practices of virtual sports brand communities.
Digital literacy and subjective happiness of low-income groups: Evidence from rural China
Authors: Wang Jie , Liu Chang , Cai Zhijian
Published: November 2022

Improvements of the happiness of the rural population are an essential sign of the effectiveness of relative poverty governance. In the context of today’s digital economy, assessing the relationship between digital literacy and the subjective happiness of rural low-income groups is of great practicality. Based on data from China Family Panel Studies, the effect of digital literacy on the subjective well-being of rural low-income groups was empirically tested. A significant happiness effect of digital literacy on rural low-income groups was found. Digital literacy promotes the subjective happiness of rural low-income groups through income increase and consumption growth effects. The observed happiness effect is heterogeneous among different characteristic groups, and digital literacy significantly positively impacts the subjective happiness of rural low-income groups. Decomposition of subjective happiness into life satisfaction and job satisfaction shows that digital literacy significantly positively affects the job and life satisfaction of rural low-income groups. This paper demonstrates that digital literacy induces a practical happiness effect. To further strengthen the subjective welfare effect of digital literacy in the construction of digital villages, the government should focus on cultivating digital literacy among low-income groups from the demand side. The construction of digital infrastructure should be actively promoted from the supply side.
A meta-analysis of the effects of cognitive behavioral therapy on quality of life and negative emotions of informal cancer caregivers
Authors: Zhou Shuang , Wang Yumei , Wang Qiang , Yang Guodong , Ren Huipeng , Bao Yanping
Published: November 2022

Objective

This study aimed to systematically review the effect of cognitive behavioral therapy (CBT) in terms of improving the quality of life (QOL) and negative emotion of informal cancer caregivers.

Methods

PubMed, Cochrane Library, EMBASE, Web of Science, MEDLINE, China National Knowledge Infrastructure (CNKI), and China Biology Medicine disc (CBMdisc) were searched from the database establishment to October 2021. Literature screening, data extraction, and quality evaluation were conducted based on inclusion and exclusion criteria. Stata 14.0 software was used for data analysis.

Results

A total of 17 randomized controlled trials (RCTs) involving 2,348 cancer informal caregivers (CGs) were included in this study, with an overall loss rate of 13.3%. Meta-analysis showed no statistically significant difference in the impact of CBT on QOL (SMD = 0.28, 95%CI: −0.09–0.65, P < 0.001). However, the improvement of depression in CBT intervention group was significantly better than that in control group (SMD = −0.32, 95%CI: −0.56 to −0.07, P = 0.010). The HADS subgroup showed differences in depression scores (SMD = −0.80, 95%CI: −1.30 to −0.29, P = 0.002). The overall effect of CBT on anxiety was statistically different, the improvement of anxiety in CBT intervention group was significantly better than that in control group (SMD = −0.36, 95%CI: −0.720–0.004, P = 0.047).

Conclusions

CBT had a positive effect on reducing depression and anxiety in informal cancer caregivers, and the effect on quality of life was not statistically significant, but showed a positive trend.

Systematic Review Registration

https://inplasy.com/generate-invoice/, identifier: INPLASY202230120.
Impact of COVID-19 pandemic on catheter ablation in China: A spatiotemporal analysis
Authors: Jiang Jiang , Zhao Shuang , Cheng Chendi , Lin Na , Li Ping , Ning Xiaohui , Zhang Shu
Published: November 2022

Background

The COVID-19 pandemic has significantly impacted routine cardiovascular health assessments and services. We aim to depict the temporal trend of catheter ablation (CA) and provide experience in dealing with the negative impact of the COVID-19 pandemic.

Methods

Data on CA between January 2019, and December 2021, were extracted from the National Center for Cardiovascular Quality Improvement platform. CA alterations from 2019 to 2021 were assessed with a generalized estimation equation.

Results

A total of 347,924 patients undergoing CA were included in the final analysis. The CA decreased remarkably from 122,839 in 2019 to 100,019 (−18.58%, 95% CI: −33.40% to −3.75%, p = 0.02) in 2020, and increased slightly to 125,006 (1.81%, 95% CI: −7.01% to 3.38%, p = 0.49) in 2021. The CA experienced the maximal reduction in February 2020 (−88.78%) corresponding with the peak of monthly new COVID-19 cases and decreased by 54.32% (95%CI: −71.27% to −37.37%, p < 0.001) during the 3-month lockdown and increased firstly in June 2020 relative to 2019. Since then, the CA in 2020 remained unchanged relative to 2019 (−0.06%, 95% CI: −7.01% to 3.38%, p = 0.98). Notably, the recovery of CA in 2021 to pre-COVID-19 levels was mainly driven by the growth of CA in secondary hospitals. Although there is a slight increase (2167) in CA in 2021 relative to 2019, both the absolute number and proportion of CA in the top 50 hospitals nationwide [53,887 (43.09%) vs. 63,811 (51.95%), p < 0.001] and top three hospitals in each province [66,152 (52.73%) vs. 72,392 (59.28%), p < 0.001] still declined significantly.

Conclusions

The CA experienced a substantial decline during the early phase of the COVID-19 pandemic, and then gradually returned to pre-COVID-19 levels. Notably, the growth of CA in secondary hospitals plays an important role in the overall resumption, which implies that systematic guidance of secondary hospitals with CA experience may aid in mitigating the negative impact of the COVID-19 pandemic.
What do we know about the effect of night-shift work on cardiovascular risk factors? An umbrella review
Authors: Boini Stephanie , Bourgkard Eve , Ferrières Jean , Esquirol Yolande
Published: November 2022

Objective

To evaluate the existing evidence on the effect of night-shift work and its subtypes (permanent and rotating) on cardiovascular risk factors: diabetes, lipid disorders, being overweight, hypertension, smoking habits, sedentariness, and occupational psychosocial stressors.

Method

A Web of Sciences and Cochrane review library search was conducted to identify systematic reviews with or without meta-analysis dealing with the quantification of the link between night-shift work and the studied cardiovascular risk factors in working populations. We used the AMSTAR 2 to evaluate the quality of each review. The main results of the included systematic reviews were compiled in a summary structured around the different cardiovascular risk factors.

Results

After selection, 33 systematic reviews were included: nine for diabetes, four for lipid disorders, nine for being overweight, four for hypertension, two for smoking habits, three for occupational psychosocial stressors and two for sedentariness. The results confirmed an excess risk of diabetes of about 10% regardless of the type of night work. A stated excess risk of being overweight at around 25% was also highlighted for shift workers overall, which could reach 38% among night-shift workers. An increased risk of obesity, estimated at 5% for night-shift workers and at 18% for rotating shift workers, was observed. An excess risk of hypertension was estimated at around 30% when considering the broad definition of shift work and when night periods were included in rotating shifts. The literature provided inconsistent results for the link between lipid disorders and night-shift work. Shift workers appeared to be more likely to smoke. The link between shift work and occupational psychosocial stressors was scarcely explored in the available studies. Sedentariness was scarcely considered in systematic reviews, which prevents any firm conclusions.

Conclusion

The consequences of night work in terms of diabetes, being overweight/obesity and hypertension are established. Monitoring of these cardiovascular risk factors for these night-shift workers could be implemented by practitioners. In contrast, the links with lipid disorders, sedentariness, smoking habits, and occupational psychosocial stressors warrant further investigation.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021275212, PROSPERO (ID CRD42021275212)
Staging study of single-channel sleep EEG signals based on data augmentation
Authors: Ling Huang , Luyuan Yao , Xinxin Li , Bingliang Dong
Published: November 2022

Introduction

Accurate sleep staging is an essential basis for sleep quality assessment and plays an important role in sleep quality research. However, the occupancy of different sleep stages is unbalanced throughout the sleep process, which makes the EEG datasets of different sleep stages have a class imbalance, which will eventually affect the automatic assessment of sleep stages.

Method

In this paper, we propose a Residual Dense Block and Deep Convolutional Generative Adversarial Network (RDB-DCGAN) data augmentation model based on the DCGAN and RDB, which takes two-dimensional continuous wavelet time–frequency maps as input, expands the minority class of sleep EEG data and later performs sleep staging by Convolutional Neural Network (CNN).

Results and discussion

The results of the CNN classification comparison test with the publicly available dataset Sleep-EDF show that the overall sleep staging accuracy of each stage after data augmentation is improved by 6%, especially the N1 stage, which has low classification accuracy due to less original data, also has a significant improvement of 19%. It is fully verified that data augmentation by improving the DCGAN model can effectively improve the classification problem of the class imbalance sleep dataset.
The current state of public health education in India: A scoping review
Authors: Joshi Ashish , Bhatt Ashruti , Gupta Mansi , Grover Ashoo , Saggu Sofia Rani , Malik Isha Vikas
Published: November 2022

With the creation of public health management cadre in the state, district, and block levels of India, there is a need for a comprehensive, synergistic education system to ensure efficient public health across the country. This scoping review, therefore, aims to examine the characteristics of public health education programs available in India's varied geographical and regional contexts. It examines 16 program-related descriptors across public health Doctoral, Masters, Bachelors, Post-graduate Diploma, and Diploma education programs offered. Data was retrieved through institutional websites. Results of our analysis showed 84 unique institutions in 20 states and 3 UTs currently offering 116 public health programs across India's 28 states and 8 UTs. Private and public institutes were 65% (n = 75) and 35% (n = 41) respectfully. The majority of universities mainly provided Masters of Public Health (n = 73, 63%) programs followed by Postgraduate Diploma (PGD) and Diploma (n = 17, 15%), BPHSc (n = 14, 12%), and Ph.D. (n = 12, 10%). The majority of Ph.D. programs in public health are offered in Maharashtra, Karnataka, and Haryana, while Masters in Public Health programs are offered highest in Karnataka, Bachelors in Public Health programs in Rajasthan, Post Graduate Diploma in Public Health program in Delhi, and Tamil Nadu had the most number of Diploma in Public Health programs. Thirty-one percent (n = 36) of the public health programs are offered across the south, 28% (n = 32) across the north, and 22% (n = 26) across the west Analyzed descriptors provide comprehensive information on program characteristics, mainly admission, format, and tuition fee. The review offers five suggestions to improve collaborative public health education and prepare a workforce with the skills, knowledge, and expertise to respond to the twentyfirst century's public health threats and challenges in India.
“I'm sick of being called a hero – I want to get paid like one”: Filipino American frontline workers' health under conditions of COVID-19 and racial capitalism
Authors: Sangalang Cindy C.
Published: November 2022

Although the era of COVID-19 has reaffirmed the vital role of frontline workers in maintaining a functional society, the ongoing pandemic has taken a devastating toll on their health and well-being. In the United States, Filipino American frontline workers in healthcare and service industries have endured threats to their health, safety, and economic livelihood throughout the pandemic and against the broader backdrop of racialized and xenophobic hate directed toward Asian Americans. Drawing on a qualitative approach, the current study explores work-related health risks and effects of the pandemic for Filipino American frontline workers. Data come from the qualitative arm of a larger mixed-methods study that used a community-based participatory research approach. The current analysis is based on focus group data with thirty-five Filipino American frontline workers, a majority of whom were migrants, that worked across healthcare, caregiving, education, childcare, food services, and retail industries. Situated through the lens of racial capitalism, themes included: (1) work-related stress, tensions, and trauma, (2) anti-Asian racism and intersections with age- and gender-based violence, and (3) working while ill and distressed. Study findings can inform interventions and policies to improve health, occupational environments, and labor conditions in order to support minoritized communities disproportionately affected by COVID-19.
Sex differences in epigenetic age in Mediterranean high longevity regions
Authors: Engelbrecht Hannah-Ruth , Merrill Sarah M. , Gladish Nicole , MacIsaac Julie L. , Lin David T. S. , Ecker Simone , Chrysohoou Christina A. , Pes Giovanni M. , Kobor Michael S. , Rehkopf David H.
Published: November 2022

Sex differences in aging manifest in disparities in disease prevalence, physical health, and lifespan, where women tend to have greater longevity relative to men. However, in the Mediterranean Blue Zones of Sardinia (Italy) and Ikaria (Greece) are regions of centenarian abundance, male-female centenarian ratios are approximately one, diverging from the typical trend and making these useful regions in which to study sex differences of the oldest old. Additionally, these regions can be investigated as examples of healthy aging relative to other populations. DNA methylation (DNAm)-based predictors have been developed to assess various health biomarkers, including biological age, Pace of Aging, serum interleukin-6 (IL-6), and telomere length. Epigenetic clocks are biological age predictors whose deviation from chronological age has been indicative of relative health differences between individuals, making these useful tools for interrogating these differences in aging. We assessed sex differences between the Horvath, Hannum, GrimAge, PhenoAge, Skin and Blood, and Pace of Aging predictors from individuals in two Mediterranean Blue Zones and found that men displayed positive epigenetic age acceleration (EAA) compared to women according to all clocks, with significantly greater rates according to GrimAge (β = 3.55; p = 1.22 × 10−12), Horvath (β = 1.07; p = 0.00378) and the Pace of Aging (β = 0.0344; p = 1.77 × 10−08). Other DNAm-based biomarkers findings indicated that men had lower DNAm-predicted serum IL-6 scores (β = -0.00301, p = 2.84 × 10−12), while women displayed higher DNAm-predicted proportions of regulatory T cells than men from the Blue Zone (p = 0.0150, 95% Confidence Interval [0.00131, 0.0117], Cohen’s d = 0.517). All clocks showed better correlations with chronological age in women from the Blue Zones than men, but all clocks showed large mean absolute errors (MAE >30 years) in both sexes, except for PhenoAge (MAE <5 years). Thus, despite their equal survival to older ages in these Mediterranean Blue Zones, men in these regions remain biologically older by most measured DNAm-derived metrics than women, with the exception of the IL-6 score and proportion of regulatory T cells.
Tissue specific age acceleration patterns in the sperm of oligozoospermic men
Authors: Stalker Kelaney , Pollard Chad , Aston Kenneth , Jenkins Tim
Published: November 2022

To determine if disease can modify aging patterns in an affected tissue without altering the aging patterns of other tissues, blood and semen of individuals with oligozoospermia (n = 10) were compared to the blood and semen of individuals with normozoospermia (n = 24). DNA methylation data was obtained via Illumina's 850 K array. The Horvath and Jenkins age calculators were then utilized to predict the epigenetic age of blood and sperm. Epigenetic age of sperm was approximated using germ-line age differential (GLAD) values. Using nonpaired t-tests, it was found that sperm of oligozoospermic men (mean GLAD score of 0.078) were predicted to be significantly older than the sperm of normozoospermic men (mean GLAD score of −0.017), returning a p-value of 0.03. However, there was not a significant epigenetic age difference between the blood of those with oligozoospermia (mean GLAD equivalent score of −0.027) and normozoospermia (mean GLAD equivalent score of 0.048), producing a p-value of 0.20. These results lead to the conclusion that tissue specific aging is occurring in sperm of oligozoospermic individuals but not in unaffected somatic tissues (in this case, blood).
Forest digital twin as a relaxation environment: A pilot study
Authors: Hejtmánek Lukáš , Hůla Martin , Herrová Anna , Surový Peter
Published: November 2022

Forest environments have been proven beneficial for physiological well-being, supporting relaxation and meditative processes. Unfortunately, some groups, predominantly those with reduced mobility, are prevented from forest visitation. Presenting such environments in virtual reality could provide a viable substitute. However, as forest structure and composition are important aspects of its restorative power, to accurately compare the efficacy of virtual forests to that of real natural spaces, the virtual environment should match the real location as closely as possible. Furthermore, if participants achieve similar benefits in both settings, virtual copies (digital twins) of forests could be a viable option for studying forest bathing in a controlled environment. We collected LiDAR scans of a forest location near Prague, took spatial audio recordings of the forest ambiance, and built the forest’s digital twin in Unreal Engine. To compare the therapeutic efficacy of the virtual forest with its real counterpart, groups of volunteers spent half an hour in either the real forest, the virtual forest, or both. We collected participants’ demographic and psychometric data, assessing their relaxation, emotional state, and cybersickness before and after the session. Our data show an increase in relaxation with no significant differences between the environments, although participants’ emotional states did not improve in either condition. We found that participants’ experiences were comparable between the environments, but cybersickness limited the potential efficacy of virtual forest bathing. The limitations of the virtual forests as a platform for research into forest bathing are discussed.
Automating virtualization of machinery for enabling efficient virtual engineering methods
Authors: Michels Felix Longge , Häfner Victor
Published: November 2022

Virtual engineering as a new working method in product development should make it much easier to validate the development progress and facilitate team communication. Work steps are brought forward and start with the virtual components instead of real ones. To validate mechanical and electrical CAD as well as programming, automated virtualization systems should create the virtual twin of the machine at the push of a button. For this purpose, generic intelligence is added to enable complex interactive virtual models that can be used for training, monitoring and many other applications. Advanced applications are for example training and support applications, especially in combination with augmented reality and remote collaboration. We propose a system that combines virtual reality, virtual engineering and artificial intelligence methods for the product development process. Geometry analysis algorithms are used to process mechanical CAD data and thus, for example, to automatically parameterize kinematic simulations. In combination with electrical CAD data and the simulations of electric circuits as well as the original machine program allow simulating the behavior of the machine and the user interaction with it. This article will describe the virtualization method in detail and present various use-cases in special machine construction. It will also propose a novel method to use causal discovery in complex machine simulations.
Intravenous thrombolysis in ischemic stroke patients based on non-contrast CT in the extended time-window
Authors: Emde Julia , Baumgart Romy , Langguth Niklas , Juenemann Martin , Gerner Stefan T.
Published: November 2022

Purpose of review

Recent trials provided evidence for safety and efficacy of intravenous thrombolytic therapy (IVT) in ischemic stroke patients beyond the 4.5 h time-window if ischemic penumbra is present in multimodal imaging. However, advanced imaging by either Magnet Resonance Imaging (MRI) or Computed Tomography Perfusion (CTP) is not available 24/7 at most stroke-centers. Therefore, the current review addresses the use of non-contrast CT (NCCT) to identify ischemic stroke patients suitable for IVT in the unknown or extended time-window in terms of efficacy and safety.

Recent findings

The current data on NCCT based IVT strategies in ischemic stroke patients presenting in the unknown or late time-window are relatively scarce and mainly provided by small retrospective samples. One larger registry (TRUST-CT) underlines the safety and efficacy of IVT without advanced imaging with more IVT-patients reaching an excellent outcome compared to the non-IVT treated control group. Current meta-analysis provides evidence that the rate of symptomatic intracerebral hemorrhage (sICH) is similar in the wake-up and unknown onset time-window compared to the 4.5 h time-window if patients are selected by NCCT. Results of the upcoming TWIST-trial investigating Tenecteplase (TNK) for NCCT-based IVT revealed no signals regarding an increased rate of sICH, however there was no benefit regarding functional outcomes.

So far, it is not well-established whether advanced imaging is indispensable and NCCT could be sufficient to identify stroke patients in the extended window who would benefit from IVT-treatment. However, current data suggests the safety of NCCT-based IVT in the extended time-window. Therefore, unavailable advanced neuroimaging should not cause delay, or even exclusion of patients from IVT and other recanalizing therapies per se.
Standardized evaluation of satisfaction within urology residents during clinical training: Implementation of a new urological residency rotation program at the university hospital Frankfurt
Authors: Siech Carolin , García Cristina Cano , Leyh Herbert , Schmid Hans-Peter , Engl Tobias A , Karakiewicz Pierre I , Becker Andreas , Chun Felix K-H , Banek Séverine , Kluth Luis A
Published: November 2022

Background

Structured curricula are demanded to improve training programs of future urologists. This study aimed to evaluate the acceptance of the newly implemented residency rotation program at the University Hospital Frankfurt. Primary endpoint was resident's satisfaction with the current residency rotation program. Secondary endpoint was the fulfilment of the objectives and expectations by residents.

Methods

A standardized 15-item, online-based survey was sent to every urologic resident of the University Hospital Frankfurt, completing their rotation between August 2020 and August 2022. In addition to baseline characteristics, training and working conditions were assessed. Descriptive statistics were applied.

Results

In total 15 rotations of the Residency Rotation Program at the University Hospital Frankfurt were evaluated, including urologic practice (5/15), Intermediate Care Unit (4/15), urooncology (4/15) and clinical exchange to St. Gallen (2/15). Overall, the majority were very (67%) or rather satisfied (2%) with their rotation. Of the pre-rotation defined objectives, 71% were fulfilled, 18% partially fulfilled and 8% not fulfilled. With respect to the expectations, 67% were fulfilled, 19% partly fulfilled and 4% were not fulfilled. All residents would recommend their respective rotations.

Conclusion

Our results demonstrate that the residency rotation program at the University Hospital Frankfurt enjoys a high level of acceptance as well as a positive impact on urologic training. Satisfaction with the completed rotation was convincing, most of the expectations and objectives for the respective rotation could be fulfilled. These results help to ensure the quality of urologic curricula and to improve the structure of training programs for future urologists.
Metabolic and hormonal changes after laparoscopic sleeve gastrectomy in pediatric population: An observational study
Authors: Alghamdi Hashim , Asiri Ashwag , Alzahrani Faris , Alamri Zainab , AbdelQadir Yossef Hassan , Shah Jaffer
Published: November 2022

Introduction

Despite the growing popularity of laparoscopic sleeve gastrectomy (SG) for managing severe obesity in children, adolescents, and adults, there is a paucity of studies reporting the effects of SG on metabolic and hormonal outcomes in pediatric populations.

Methodology

In this single-centre, retrospective study, we assessed nutritional biomarkers (hemoglobin, ferritin, iron profile, Vitamin B12, Vitamin D, and calcium), glucose homeostasis indicators (C-peptide, HbA1C, and random blood glucose), blood lipids (triglycerides and cholesterol components), hormones involved in the hypothalamic-pituitary-adrenal axis (cortisol and adrenocorticotropic hormone), and thyroid hormones (T3, T4, thyroid-stimulating hormone, and parathyroid hormone) preoperatively and 12-month after SG in children aged 5–15 years.

Results

This study included 64 adolescents (mean age = 11.2 ± 2.3 years) who underwent laparoscopic SG. Significant reduction in circulatory C-peptide (−62.1%; p = 0.005), HbA1C (−10.9%; p = 0.001), random blood glucose (−15.4%; p = 0.036), and triglycerides (−39.4%; p = 0.003) were observed postoperatively at 12 months compared to baseline. Although we did not observe any changes in cortisol levels, adrenocorticotropic hormone levels declined significantly by −40.9% postoperatively (p = 0.033). However, cholesterol components, thyroid hormones, and nutritional biomarkers remained unchanged from baseline.

Conclusions

Consistent with prior literature, our study demonstrates improvement or resolution of diabetes and hypertriglyceridemia in the year following SG. However, given that blood cholesterol components, nutritional biomarkers, and thyroid profiles remained unchanged warrants long-term monitoring of nutritional, metabolic, and endocrine factors in adolescents undergoing laparoscopic SG. To the best of our knowledge, this is the first study reporting the effects of SG on thyroid and hypothalamic-pituitary-adrenal axis hormones in pediatric populations.
Informal Support Networks of Tanzanians With Chronic Diseases: Predictors of Support Provision and Treatment Adherence
Authors: Hooley Brady , Mtenga Sally , Tediosi Fabrizio
Published: November 2022

Objectives: To examine the role of NCD patients’ social ties as informal caregivers and whether receiving their support is associated with engagement in care.

Methods: NCD outpatients (N2 = 100) in rural Tanzania completed a cross-sectional questionnaire to characterize the support role of their social ties (N1 = 304). Bivariate analyses explored predictors of social support and whether social support is associated with engagement in care.

Results: This study found that 87% of participants had health insurance, yet 25% received financial support for financing healthcare. Patient gender, age and marital status were found to be important predictors of social support, with NCD-related disability and disease severity being predictive to a lesser degree. Monthly receipt of both material and non-material support were associated with increased odds of adherence to prescribed medications.

Conclusion: These findings indicate that patients’ social ties play an important role in filling the gaps in formal social health protection and incur substantial costs by doing so. The instrumental role of even non-material social support in promoting engagement in care deserves greater attention when developing policies for improving this population’s engagement in care.
Endoscopic Intrapyloric Botulinum Toxin Injection with Pyloric Balloon Dilation for Symptoms of Delayed Gastric Emptying after Distal Esophagectomy for Esophageal Cancer: A 10-Year Experience
Authors: Bhutani Manoop S. , Ejaz Shamim , Cazacu Irina M. , Singh Ben S. , Shafi Mehnaz , Stroehlein John R. , Mehran Reza J. , Walsh Garrett , Vaporciyan Ara , Swisher Stephen G. , Hofstetter Wayne
Published: November 2022

Patients with esophageal cancer undergoing esophagectomy have an improved survival over time, however adverse events associated with the use of a gastric conduit are increasingly being reported. Delayed gastric emptying (DGE) is an esophagectomy-related complication which can decreased quality of life by causing debilitating gastrointestinal symptoms and malnutrition. The aim of our study was to evaluate the effect of endoscopic intrapyloric botulinum (BT) injection in combination with pyloric balloon dilation in patients with DGE following distal esophagectomy at our tertiary cancer center. Patients with a prior history of distal esophagectomy who had also undergone endoscopic BT injection with pyloric balloon dilation by a single endoscopist between 2007 and 2017 were included in the study. One hundred units of BT were injected endoscopically into the pylorus in four quadrants using an injection needle. Following BT injection, a standard through-the-scope balloon was passed to the pylorus and inflated to a maximum diameter of 12–20 mm. For patients who underwent repeat procedures, the symptomatic outcomes were assessed and documented by the endoscopist; for the other patients, the electronic medical records were reviewed. A total of 21 patients undergoing 44 endoscopic intrapyloric botox injections combined with balloon dilatations were identified. The patients underwent the procedures at a median of 22 months (range, 1–108 months) after esophagectomy. The procedures were performed only once in 43% of the patients; 43% patients underwent the procedure twice, while 14% had it multiple times (>2). Overall, intrapyloric BT injection coupled with balloon dilation was a safe procedure, without any major immediate or delayed (1 month) procedure-related adverse events. Eighteen patients (85%) reported a significant overall improvement in symptoms from the initial presentation. One patient (5%) showed no improvement, whereas in two (10%) patients responses were not available. In our particular cohort of patients, the interventions of endoscopic intrapyloric BT injection with pyloric balloon dilation proved to be very beneficial, leading to significant symptomatic improvement. The balloon dilation after BT injection might have resulted in better diffusion of the BT into the pyloric sphincter complex, possibly increasing its therapeutic effects. Further prospective studies are needed to validate these results.
A Literary Shadow Study
Authors: Wall Amanda
Published: November 2022

A shadow study can be an effective way to consider a student’s experience in school. For teacher candidates, engaging in a shadow study can be a responsive approach supporting growing habits of translating theory into practice and making connections among course concepts, research, theory, and principles. When middle-level teacher candidates were unable to have field experiences in recent semesters due to COVID-19, they instead took part in a literary shadow study of a character in a novel for young adolescents. After taking running notes while reading, they connected aspects of the character (including thoughts, words, and actions) to research and principles about education for young adolescents. This was a collective case study to determine overall themes across two cohorts of teacher candidates’ shadow studies. Each candidate’s literary shadow study was a source of data, analyzed through discourse analysis. The AMLE standards for middle level teacher preparation were start codes; other codes were identified through data analysis. This study builds on the scant research on the shadow study procedure and presents evidence of teacher candidates’ learning about young adolescent development as well as middle level structures, and how they connect these ideas to specific student experiences (in this case, fictional) and their own identities as teachers.
Design and Analysis of a Floating Photovoltaic System for Offshore Installation: The Case Study of Lampedusa
Authors: Ghigo Alberto , Faraggiana Emilio , Sirigu Massimo , Mattiazzo Giuliana , Bracco Giovanni
Published: November 2022

In recent years, numerous projects for floating PV systems have been developed. These plants of various sizes have mainly been installed on enclosed lakes or basins characterised by the absence of external forcing related to waves and currents. However, offshore installation would allow the development of such plants in areas where land is not available, such as islands. This paper analyses the state of the art of floating PV, describes the design of a floating PV platform and the development of a numerical model to evaluate the system performance in an offshore environment. The case study of the island of Lampedusa is then analyzed: starting from a single floating foundation with its mooring system, a floating PV system is designed to meet the island’s electricity needs. In order to provide the competitiveness of the system, a techno-economic analysis is carried out, evaluating the main cost items of Capex, Opex and LCOE. Although the LCOE obtained is significantly higher than a traditional solar plant installed on land, this technology is competitive compared to other offshore marine technologies such as offshore wind and wave energy.
Sustainable Construction—Technological Aspects of Ecological Wooden Buildings
Authors: Stepien Anna , Piotrowski Jerzy Zbigniew , Munik Sławomir , Balonis Magdalena , Kwiatkowska Milena , Krechowicz Maria
Published: November 2022

Wooden construction constitutes a specific branch of the building industry that focuses on high-quality materials, a developed sense of aesthetics connected with comfort and functionality, and concern for ecology and durability. This type of construction has a positive effect on human quality of life. This article focuses on modular frame construction and technological aspects of wooden houses built according to Canadian or Scandinavian technologies. Taking weather conditions of Scandinavian countries into consideration, timber is a popular building material, which, when preserving certain parameters such as density of rings, may provide durability of a modular wooden building even up to 200–300 years. This article is a review and presents the possibility of producing frame buildings in Europe (Poland) in accordance with the applicable standards, including a heat transfer coefficient U = 2 [W/(m²·K]. In Poland, wooden frame buildings can be traced back to the 14th century. Wooden frame buildings and modular wooden frame buildings were produced even earlier in Norway. Wooden construction continued in the mid-1800s in various forms (with wooden filling and/or panels). In the mid-1900s (1941), certain dimensioning became regulated by law, which then applied to different types of insulation fillings. Prefabricated modular wood frame houses were common in the 1960s.
Learners’ Knowledge of Environmental Education in Selected Primary Schools of the Tshwane North District, Gauteng Province
Authors: Mashaba Ernest Khalabai , Maile Simeon , Manaka Malose Jack
Published: November 2022

This study focused on determining the level of environmental education knowledge and skills among primary school learners in South Africa, under the National Curriculum Statement Grades R-12. Environmental education is important in the promotion of sustainable environmental conservation and reducing negative effects, which are caused by adverse climatic conditions. We used a qualitative approach for data collection from eight primary schools located in the North Tshwane District of Gauteng province, through interviews and observations. The sample comprise teachers, learners, and non-teaching staff working at the schools. The findings from interviews suggest that the curriculum offers learners adequate environmental educational knowledge in the Social Science and Natural Science subjects. Similarly, the results from the observations show that, from visual sights of the surroundings of the schools, the school has gardens, tree nurseries, tree plantations, and a clean environment around the school. In conclusion, learners are provided with adequate environmental educational knowledge and they are able to contribute towards maintaining a clean environment and conservation in their communities.
Visualizing Intramolecular Dynamics of Membrane Proteins
Authors: Ohkubo Tatsunari , Shiina Takaaki , Kawaguchi Kayoko , Sasaki Daisuke , Inamasu Rena , Yang Yue , Li Zhuoqi , Taninaka Keizaburo , Sakaguchi Masaki , Fujimura Shoko , Sekiguchi Hiroshi , Kuramochi Masahiro , Arai Tatsuya , Tsuda Sakae , Sasaki Yuji C. , Mio Kazuhiro
Published: November 2022

Membrane proteins play important roles in biological functions, with accompanying allosteric structure changes. Understanding intramolecular dynamics helps elucidate catalytic mechanisms and develop new drugs. In contrast to the various technologies for structural analysis, methods for analyzing intramolecular dynamics are limited. Single-molecule measurements using optical microscopy have been widely used for kinetic analysis. Recently, improvements in detectors and image analysis technology have made it possible to use single-molecule determination methods using X-rays and electron beams, such as diffracted X-ray tracking (DXT), X-ray free electron laser (XFEL) imaging, and cryo-electron microscopy (cryo-EM). High-speed atomic force microscopy (HS-AFM) is a scanning probe microscope that can capture the structural dynamics of biomolecules in real time at the single-molecule level. Time-resolved techniques also facilitate an understanding of real-time intramolecular processes during chemical reactions. In this review, recent advances in membrane protein dynamics visualization techniques were presented.
Out of the Shadow: Blue Light Exposure Induces Apoptosis in Müller Cells
Authors: Fietz Agnes , Hurst José , Schnichels Sven
Published: November 2022

Awareness toward the risks of blue light (BL) exposure is rising due to increased use of BL-enriched LEDs in displays. Short-wave BL (400–500 nm) has a high photochemical energy, leading to the enhanced production of reactive oxygen species (ROS). BL potentially plays a role in causing dry eye, cataracts, and age-related macular degeneration (AMD). The effect of BL on retinal pigment epithelium cells (RPEs) or photoreceptors has been extensively investigated. In contrast, only a few studies have investigated the effects of BL exposure on Müller cells (MCs). This is mainly due to their lack of photosensitive elements and the common assumption that their reaction to stress is only secondary in disease development. However, MCs perform important supportive, secretory, and immune functions in the retina, making them essential for retinal survival. Increased oxidative stress is a key player in many retinal diseases such as AMD or glaucoma. We hypothesize that increased oxidative stress can also affect MCs. Thus, we simulated oxidative stress levels by exposing primary porcine MCs and human MIO-M1 cells to BL. To confirm the wavelength-specificity, the cells were further exposed to red (RL), purple (PL), and white light (WL). BL and WL exposure increased ROS levels, but only BL exposure led to apoptosis in primary MCs. Thus, BL accounted for the harmful part of WL exposure. When cells were simultaneously exposed to BL and RL (i.e., PL), cell damage due to BL could be partly prevented, as could the inhibition of p53, demonstrating the protective effect of RL and p53 dependency. In contrast, BL hardly induced apoptosis in MIO-M1 cells, which is likely due to the immortalization of the cells. Therefore, enhanced oxidative stress levels can significantly harm MC function, probably leading to decreased retinal survival and, thus, further enhancing the progression of retinal diseases. Preventing the cell death of these essential retinal cells represents a promising therapy option to enhance retinal survival.
Natural Compound 2,2′,4′-Trihydroxychalcone Suppresses T Helper 17 Cell Differentiation and Disease Progression by Inhibiting Retinoid-Related Orphan Receptor Gamma T
Authors: Yang Yana , Qi Wenhui , Zhang Yanyan , Wang Ruining , Bao Mingyue , Tian Mengyuan , Li Xing , Zhang Yuan
Published: November 2022

Retinoid-related orphan receptor γt (RORγt), a vital transcription factor for the differentiation of the pro-inflammatory Th17 cells, is essential to the inflammatory response and pathological process mediated by Th17 cells. Pharmacological inhibition of the nuclear receptor RORγt provides novel immunomodulators for treating Th17-driven autoimmune diseases and organ transplant rejection. Here, we identified 2,2′,4′-trihydroxychalcone (TDC), a natural chalcone derivant, binds directly to the ligand binding domain (LBD) of RORγt and inhibited its transcriptional activation activity. Using three mice models of Th17-related diseases, it was found that the administration of TDC effectively alleviated the disease development of experimental autoimmune encephalomyelitis (EAE), experimental colitis, and skin allograft rejection. Collectively, these results demonstrated TDC targeting RORγt to suppress Th17 cell polarization, as well as its activity, thus, indicating the potential of this compound in treating of Th17-related autoimmune disorders and organ transplant rejection disorders.