bluuebunny/crossref_metadata_2025 huggingface dataset:
External validation and longitudinal application of the DO-GAP index to individualise survival prediction in idiopathic pulmonary fibrosis
Authors: Chandel Abhimanyu , King Christopher S. , Ignacio Rosalinda V. , Pastre Jean , Shlobin Oksana A. , Khangoora Vikramjit , Aryal Shambhu , Nyquist Alan , Singhal Anju , Flaherty Kevin R. , Nathan Steven D.
Published: May 2023

Background

The Distance-Oxygen-Gender-Age-Physiology (DO-GAP) index has been shown to improve prognostication in idiopathic pulmonary fibrosis (IPF) compared to the Gender-Age-Physiology (GAP) score. We sought to externally validate the DO-GAP index compared to the GAP index for baseline risk assessment in patients with IPF. Additionally, we evaluated the utility of serial change in the DO-GAP index in predicting survival.

Methods

We performed an analysis of patients with IPF from the Pulmonary Fibrosis Foundation-Patient Registry (PFF-PR). Discrimination and calibration of the two models were assessed to predict transplant-free survival and IPF-related mortality. Joint longitudinal time-to-event modelling was utilised to individualise survival prediction based on DO-GAP index trajectory.

Results

There were 516 patients with IPF from the PFF-PR with available demographics, pulmonary function tests, 6-min walk test data and outcomes included in this analysis. The DO-GAP index (C-statistic: 0.73) demonstrated improved discrimination in discerning transplant-free survival compared to the GAP index (C-statistic: 0.67). DO-GAP index calibration was adequate, and the model retained predictive accuracy to identify IPF-related mortality (C-statistic: 0.74). The DO-GAP index was similarly accurate in the subset of patients taking antifibrotic medications. Serial change in the DO-GAP index improved model discrimination (cross-validated area under the curve: 0.83) enabling the personalised prediction of disease trajectory in individual patients.

Conclusion

The DO-GAP index is a simple, validated, multidimensional score that accurately predicts transplant-free survival in patients with IPF and can be adapted longitudinally in individual patients. The DO-GAP may also find use in studies of IPF to risk stratify patients and possibly as a clinical trial end-point.
Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcoma
Authors: Wang Hongsheng , Jin Xinmeng , Gao Yinghua , He Xin , Xu Yiming , Mu Haoran , Jiang Yafei , Wang Zhuoying , Yu Chen , Zhang Tao , Hua Yingqi , Cai Zhengdong , Xu Jing , Ma Xiaojun , Sun Wei
Published: May 2023

Background

Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) and vascular aberrations in the TME. TME reprogramming is a promising therapeutic approach for treating tumors. Anti-angiogenesis has the power to control the polarization of macrophages, prevent progression, and increase drug penetration. Additionally, polyamine blocking therapy can increase CD8+ T cell infiltration and decrease immunosuppressive cells. These results led to developing a potential therapeutic regimen that targets TAMs and angiogenesis to reprogram the osteosarcoma TME.

Results

For the targeted biomimetic co-delivery of regorafenib and alpha-difluoromethylornithine via the mannose receptor, which is overexpressed in both TAMs and osteosarcoma cells, mannosylated poly(lactide-co-glycolide)-polyethylene glycol nanoparticles (Man-NPs) were synthesized. The superior physiological properties and intratumoral accumulation of the Man-NPs efficiently promoted TAMs polarization and inhibited angiogenesis. Macrophage repolarization further activated immune cells, which contributed to remodeling the TME.

Conclusion

Overall, these findings suggested that using Man-NPs as an immunotherapeutic approach to treat osteosarcoma may be promising.

Graphical Abstract
Characterization of oral bacterial and fungal microbiome in recovered COVID-19 patients
Authors: Wei Nana , Zhu Guangqi , Zhao Tingxiao , Wang Yan , Lou Haifei , Li Haoxuan , Yang Zhejuan , Zhang Zheen , Wang Qiujing , Han Mingfang , Lin Zhibing , Li Shibo
Published: May 2023

COVID-19 has emerged as a global pandemic, challenging the world’s economic and health systems. Human oral microbiota comprises the second largest microbial community after the gut microbiota and is closely related to respiratory tract infections; however, oral microbiomes of patients who have recovered from COVID-19 have not yet been thoroughly studied. Herein, we compared the oral bacterial and fungal microbiota after clearance of SARS-CoV-2 in 23 COVID-19 recovered patients to those of 29 healthy individuals. Our results showed that both bacterial and fungal diversity were nearly normalized in recovered patients. The relative abundance of some specific bacteria and fungi, primarily opportunistic pathogens, decreased in recovered patients (RPs), while the abundance of butyrate-producing organisms increased in these patients. Moreover, these differences were still present for some organisms at 12 months after recovery, indicating the need for long-term monitoring of COVID-19 patients after virus clearance.
German translation, cultural adaptation and validation of the Person-Centred Practice Inventory—Staff (PCPI-S)
Authors: von Dach Christoph , Schlup Nanja , Gschwenter Stefan , McCormack Brendan
Published: May 2023

Background

The person-centred practice framework represents the cornerstone of a middle-range theory. Internationally, person-centredness has become an increasingly common topic. The measurement of the existence of a person-centred culture is complex and subtle. The Person-Centred Practice Inventory—Staff (PCPI-S) measures clinicians’ experience of a person-centred culture in their practice. The PCPI-S was developed in English. Therefore, the aims of this study were (1) to translate the PCPI-S into German and to cross-culturally adapt and test in the acute care setting (PCPI-S aG Swiss) and (2) to investigate the psychometric properties of the PCPI-S aG Swiss.

Methods

The two-phase investigation of this cross-sectional observational study followed the guidelines and principles of good practice for the process of translation and cross-cultural adaptation of self-reporting measures. Phase 1 involved an eight-step translation and cultural adaptation of the PCPI-S testing in an acute care setting. In Phase 2, psychometric retesting and statistical analysis based on a quantitative cross-sectional survey were undertaken. To evaluate the construct validity, a confirmatory factor analysis was implemented. Cronbach’s alpha was used to determine the internal consistency.

Results

A sample of 711 nurses working in a Swiss acute care setting participated in testing the PCPI-S aG Swiss. Confirmatory factor analysis indicated a good overall model fit, validating the strong theoretical framework, which underpins the PCPI-S aG Swiss. Cronbach’s alpha scores demonstrated excellent internal consistency.

Conclusion

The chosen procedure ensured cultural adaptation to the German-speaking part of Switzerland. The psychometric results were good to excellent and comparable with other translations of the instrument.
Efficacy of dapagliflozin in the treatment of HFrEF with obstructive sleep apnea syndrome (DAHOS study): study protocol for a multicentric, prospective, randomized controlled clinical trial
Authors: Xie Liang , Song Songsong , Li Shengnan , Wei Qin , Liu Hong , Zhao Chao , Yu Fuchao , Tong Jiayi
Published: May 2023

Background

Heart failure with reduced ejection fraction (HFrEF) is associated with sleep dyspnea (SDB), which plays an adverse role in the pathophysiology of the condition. SDB management in HFrEF, however, remains controversial. HFrEF’s medical management has recently made significant progress with the discovery of new therapeutic avenues, namely sodia-glucose cotransporter-2 (SGLT-2) inhibitors, and better treatment of co-morbidities. Dapagliflozin, one of the SGLT-2 inhibitors, is a good candidate for correcting SDB of HFrEF patients because their known mechanisms of action are likely to counteract the pathophysiology of SDB in HFrEF.

Methods/design

The trial is a 3-month, multicentric, prospective, randomized controlled clinical study. Patients (i.e., adults with left ventricular ejection fraction ≤ 40%, Apnoea–Hypopnoea Index ≥ 15) will be randomized to receive optimized heart failure therapy plus a standard dose of dapagliflozin, while the control group will receive only optimized heart failure therapy. Patients will be evaluated before and after 3 months (nocturnal ventilatory polygraphy, echocardiography, laboratory testing, and quality-of-life and SDB questionnaires). The primary outcome is the change in the Apnoea–Hypopnoea Index, before and after 3 months of treatment.

Trial registration

www.chictr.org.cn, ChiCTR2100049834. Registered 10 August 2021.
The effect of implementing a critical thinking intervention program on English language learners’ critical thinking, reading comprehension, and classroom climate
Authors: Moghadam Zahra Bakhtiari , Narafshan Mehry Haddad , Tajadini Massoud
Published: May 2023

Entering the age of globalization and multi-cultures, the education system has become more accountable to provide a positive and productive learning atmosphere in which both life skills and academic skills are taught and trained. Following this welcoming trend, the present study sought to integrate a proposed critical thinking-based intervention program (3Es) on the ground of Bloom’s original and revised Taxonomy (1956, 2001) into a BA English reading course. This study examined the treatment’s effect on learners’ critical thinking, attitudes toward L2 classroom climate, and reading comprehension in an English as a foreign language context of Iran. According to the placement test results, excluding the upper-intermediate ones left a sample of 40 (29 females and 11 males) intermediate participants being assigned to two groups: control and experimental. While the former received conventional instruction, the latter was exposed to the critical thinking program presented in three stages: exposure, exploration, and evaluation. The data were derived from Honey's critical thinking questionnaire (2004), the L2-contextualized adapted version of WIHIC (What Is Happening In The Class) designed by Fraser et al. (1986), and the British Council reading comprehension tests. After analyzing the data, the results demonstrated positive changes in the experimental group participants’ critical thinking, reading comprehension, and learners’ attitudes toward classroom climate after implementing the critical thinking intervention program. Our findings contribute to firstly EFL practitioners and curriculum designers, as the main authorities in revising and developing curricula and educational facilities to include the skill of critical thinking as one of the major contributors to the positive atmosphere of the class, and next to the teachers to become cognizant of the influential role of critical thinking in students’ attitudes toward the classroom and their academic development.
Molecular mechanisms of Ustilaginoidea virens pathogenicity and their utilization in disease control
Authors: Yu Siwen , Liu Pengwei , Wang Jiyang , Li Dayong , Zhao Dan , Yang Cui , Shi Dongyu , Sun Wenxian
Published: May 2023

Rice false smut, caused by Ustilaginoidea virens, is one of the most important diseases in rice. The disease not only causes significant yield losses in China and worldwide but also produces multiple types of mycotoxins that pose a serious threat to the health of humans and animals. To effectively prevent and control the disease, the pathogenicity mechanisms of U. virens have been studied preliminarily, and some control strategies have been developed. This review focuses on recent progress in understanding the molecular mechanisms of U. virens pathogenicity, including virulence-related genes, transcriptional regulation of virulence genes, and effector-mediated interactions between rice and U. virens. Based on the molecular mechanisms underlying the rice-U. virens interactions, the possibilities of the pathogenicity genes in U. virens and host immune-related genes as potential targets for biological agents, host-induced gene silencing, and molecular design breeding are also discussed.
Inner structure of monogenetic Pilot Knob submarine volcano (Austin, Texas) revealed by electrical resistivity tomography and magnetic surveys
Authors: Saribudak Mustafa
Published: May 2023

Pilot Knob is the eroded and exposed core of an extinct subaqueous to emergent volcano that formed in a shallow Late Cretaceous epicontinental sea in the ancient Gulf of Mexico during the deposition of Austin Chalk Limestone. With the aim of understanding the inner structure of this volcano, we have conducted geophysical surveys (resistivity and magnetometry) to provide an insight into the past eruptive history. High-resolution electrical resistivity and magnetic data reveal, for the first time, a buried tuff mound, an explosion crater, several dikes and vents, basaltic flows, and limestone blocks within the volcano. A combination of geologic and geophysical data suggests that Pilot Knob volcano started with an explosion as a maar-type volcano beneath a shallow sea floor. Then, it likely has evolved into a tuff mound-type volcano with “Surtseyan” eruptions, before finally evolving into an emergent volcanic center. Major resistivity and magnetic anomalies align approximately in the east–west and north–south directions, respectively. Such alignments suggest that Pilot Knob is situated on east–west and north–south fractures, along which its most significant volcanic activity occurred. Results also provide valuable information in delineating tuff mounds and their structural characteristics.
Cortical morphological heterogeneity of schizophrenia and its relationship with glutamatergic receptor variations
Authors: Ouyang Xuan , Pan Yunzhi , Chen Xudong , Wu Guowei , Cheng Yixin , Tan Wenjian , Zhang Manqi , Deng Mengjie , Liu Zhening , Palaniyappan Lena
Published: May 2023

Background

Recent genetic evidence implicates glutamatergic-receptor variations in schizophrenia. Glutamatergic excess during early life in people with schizophrenia may cause excitotoxicity and produce structural deficits in the brain. Cortical thickness and gyrification are reduced in schizophrenia, but only a subgroup of patients exhibits such structural deficits. We delineate the structural variations among unaffected siblings and patients with schizophrenia and study the role of key glutamate-receptor polymorphisms on these variations.

Methods

Gaussian Mixture Model clustering was applied to the cortical thickness and gyrification data of 114 patients, 112 healthy controls, and 42 unaffected siblings to identify subgroups. The distribution of glutamate-receptor (GRM3, GRIN2A, and GRIA1) and voltage-gated calcium channel (CACNA1C) variations across the MRI-based subgroups was studied. The comparisons in clinical symptoms and cognition between patient subgroups were conducted.

Results

We observed a “hypogyric,” “impoverished-thickness,” and “supra-normal” subgroups of patients, with higher negative symptom burden and poorer verbal fluency in the hypogyric subgroup and notable functional deterioration in the impoverished-thickness subgroup. Compared to healthy subjects, the hypogyric subgroup had significant GRIN2A and GRM3 variations, the impoverished-thickness subgroup had CACNA1C variations while the supra-normal group had no differences.

Conclusions

Disrupted gyrification and thickness can be traced to the glutamatergic receptor and voltage-gated calcium channel dysfunction respectively in schizophrenia. This raises the question of whether MRI-based multimetric subtyping may be relevant for clinical trials of agents affecting the glutamatergic system.
The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function
Authors: Critchley William R. , Smith Gina A. , Zachary Ian C. , Harrison Michael A. , Ponnambalam Sreenivasan
Published: May 2023

Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that programs this receptor for trafficking and proteolysis, but the ubiquitin-modifying enzymes involved are ill-defined. Herein, we used a reverse genetics screen for the human E2 family of ubiquitin-conjugating enzymes to identify gene products that regulate VEGFR2 ubiquitination and proteolysis. We found that depletion of either UBE2D1 or UBE2D2 in endothelial cells caused a rise in steady-state VEGFR2 levels. This rise in plasma membrane VEGFR2 levels impacted on VEGF-A-stimulated signalling, with increased activation of canonical MAPK, phospholipase Cγ1 and Akt pathways. Analysis of biosynthetic VEGFR2 is consistent with a role for UBE2D enzymes in influencing plasma membrane VEGFR2 levels. Cell-surface-specific biotinylation and recycling studies showed an increase in VEGFR2 recycling to the plasma membrane upon reduction in UBE2D levels. Depletion of either UBE2D1 or UBE2D2 stimulated endothelial tubulogenesis, which is consistent with increased VEGFR2 plasma membrane levels promoting the cellular response to exogenous VEGF-A. Our studies identify a key role for UBE2D1 and UBE2D2 in regulating VEGFR2 function in angiogenesis.
Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters
Authors: Hayes Brandon H. , Zhu Peter Kuangzheng , Wang Mai , Pfeifer Charlotte R. , Xia Yuntao , Phan Steven , Andrechak Jason C. , Du Junhong , Tobin Michael P. , Anlas Alisya , Dooling Lawrence J. , Vashisth Manasvita , Irianto Jerome , Lampson Michael A. , Discher Dennis E.
Published: May 2023

The mechanical environment of a cell can have many effects, but whether it impacts the DNA sequence of a cell has remained unexamined. To investigate this, we developed a live-cell method to measure changes in chromosome numbers. We edited constitutive genes with GFP or RFP tags on single alleles and discovered that cells that lose Chromosome reporters (ChReporters) become non-fluorescent. We applied our new tools to confined mitosis and to inhibition of the putative tumor suppressor myosin-II. We quantified compression of mitotic chromatin in vivo and demonstrated that similar compression in vitro resulted in cell death, but also rare and heritable ChReptorter loss. Myosin-II suppression rescued lethal multipolar divisions and maximized ChReporter loss during three-dimensional (3D) compression and two-dimensional (2D) lateral confinement, but not in standard 2D culture. ChReporter loss was associated with chromosome mis-segregation, rather than just the number of divisions, and loss in vitro and in mice was selected against in subsequent 2D cultures. Inhibition of the spindle assembly checkpoint (SAC) caused ChReporter loss in 2D culture, as expected, but not during 3D compression, suggesting a SAC perturbation. Thus, ChReporters enable diverse studies of viable genetic changes, and show that confinement and myosin-II affect DNA sequence and mechano-evolution.
Sec16 and Sed4 interdependently function as interaction and localization partners at ER exit sites
Authors: Yorimitsu Tomohiro , Sato Ken
Published: May 2023

COPII proteins assemble at ER exit sites (ERES) to form transport carriers. The initiation of COPII assembly in the yeast Saccharomyces cerevisiae is triggered by the ER membrane protein Sec12. Sec16, which plays a critical role in COPII organization, localizes to ERES independently of Sec12. However, the mechanism underlying Sec16 localization is poorly understood. Here, we show that a Sec12 homolog, Sed4, is concentrated at ERES and mediates ERES localization of Sec16. We found that the interaction between Sec16 and Sed4 ensures their correct localization to ERES. Loss of the interaction with Sec16 leads to redistribution of Sed4 from the ERES specifically to high-curvature ER areas, such as the tubules and edges of the sheets. The luminal domain of Sed4 mediates this distribution, which is required for Sed4, but not for Sec16, to be concentrated at ERES. We further show that the luminal domain and its O-mannosylation are involved in the self-interaction of Sed4. Our findings provide insight into how Sec16 and Sed4 function interdependently at ERES.
Heteroleptic Cu(I) Bipyridine Complexes as Redox Photosensitizers for Photocatalytic CO2 Reduction
Authors: Takeda Hiroyuki , Takahashi Kohei , Namiki Yui , Ito Akitaka , Kurosu Masao , Muraoka Takako , Asano Motoko S
Published: May 2023

The redox photosensitizing ability of heteroleptic Cu(I) complexes containing a 2,2′–bipyridine (bpy) derivative as an α–diimine ligand was investigated in a photocatalytic CO2 reduction. When combined with fac–Mn(bpy)(CO)3Br as a multi-electron catalyst, the reaction systems generated a mixture of CO and HCOOH to a similar extent to the case using a conventional Cu(I)–phenanthroline analog by visible light irradiation in the presence of a reductant. Incorporating phenyl (ph) groups at the 4,4′–positions of the bpy ligand significantly affected the redox-photosensitization of the Cu(I)–bpy complexes due to improved visible light absorption. Owing to coplanarity between the ph groups and bpy scaffold, the former effectively increased and shifted the lowest-energy metal-to-ligand charge transfer absorption into the visible region more than the case of Cu(I) phenanthroline analogs. Furthermore, photophysical measurements and quenching experiments demonstrated that the heteroleptic Cu(I)–bpy complexes underwent efficient photoinduced-electron transfer from the reductant, generating the corresponding one-electron reduced species. Electrochemical measurements also demonstrated that Cu(I)–bpy complexes had sufficient reducing power and stability to transfer the extra electron to the Mn-complex catalyst in the one-electron reduced state, thereby reproducing the original photosensitizer.
VESTAS: NEW CHALLENGES AFTER COVID-19
Authors: Gambirage Cinara , Xavier Wlamir , Da Silva Jaison Caetano
Published: May 2023

This case contemplates the context of a multinational company that was able to reach prominence in the renewable energy market and has to make strategic choices to face a world crisis minimizing the long-term effects. Present in 81 countries, the company, designs, manufactures, installs, and services wind turbines all over the world and is one of the world leaders in renewable energy. This teaching case aims to promote a reflection on the strategic choices in turbulent moments and its possible implications strategic, operational and financial. The case can be used in undergraduate and graduate courses in the field of Corporate Strategy, International Business, and Business Ethics.
Escalar o impacto social sem perder a essência: o caso da ANIP
Authors: Barki Edgard R. , Ferreira dos Santos Lacerda Lilian
Published: May 2023

Sustentabilidade financeira, escalabilidade da operação e governança da organização são os grandes dilemas que a Articuladora de Negócios de Impacto da Periferia (ANIP) enfrenta em 2022. Se, por um lado, ela oferece formação, capital financeiro e social a empreendedores sociais de periferias, por outro, tem custos fixos altos, e o seu modelo de negócios não gera receitas, uma vez que está baseado em recebimento de doações. Como garantir a continuação da ANIP sem perder a qualidade e autonomia e, ao mesmo tempo, aumentar o impacto social e consolidar a sua expansão geográfica?
Mulheres na Câmara? Eleições em Jaborandi
Authors: De Paiva Puzzilli Comin Renata
Published: May 2023

Rodrigo, presidente do comitê de um partido político num pequeno município paulista, tinha o desafio de formar a lista de pré-candidaturas para a Câmara Municipal nas eleições de 2020 e depois decidir sobre a distribuição dos recursos partidários para as campanhas eleitorais. Sua jornada e as situações vivenciadas por ele com as demais personagens refletem desafios para a superação da sub-representação política de mulheres.
O Projeto Skin da Herbalife Brasil
Authors: Sarfati Gilberto , Rizetto Jordan , De Castro Pereira Junior Helder , Gouveia Fabio
Published: May 2023

No fim de 2014, em meio ao início da crise econômica no Brasil, o time local da Herbalife recebe anova estratégia global da companhia, estabelecendo a firme intenção de focar todo o esforço comercial no negócio de suplementos nutricionais para a gestão de peso. Essa decisão significava desinvestir em linhas não relevantes como cuidados pessoais e produtos de pele, apesar do fato de vários distribuidores utilizarem esses produtos como alavancadores de venda dos produtos nutricionais existentes. Em 2018, a Herbalife Brasil monta uma equipe multifuncional para criar propostas para enfrentar a crise. Como resultado dos trabalhos, foi criado o Projeto Skin, o lançamento de uma linha de produtos para cuidado com a pele. O caso discute a decisão de ir adiante ou não com o projeto levando em consideração o posicionamento no Brasil e a relação matriz-subsidiária.
Norfana: os desafios à viabilidade de um novo produto
Authors: Schill Ryan , Leonel Ronei , Jorgensen David F. , Groves Joshua
Published: May 2023

Norfana era um material de construção sintético usado na fabricação de produtos cerâmicos industriais e residenciais; no mercado havia apenas alguns anos, não atendeu às expectativas de vendas. A administração avaliava se a Norfana era um bom produto ou não, se a falha estava no plano de marketing ou em sua execução.
Simbiose Social: um caso de uma plataforma digital para impacto social
Authors: Manteiga Sandro , Andreassi Tales
Published: May 2023

A Simbiose Social, startup de impacto social, desenvolveu um modelo de negócio digital que democratizou o acesso a recursos de leis de incentivos fiscais, oriundos de empresas, para pequenas organizações não governamentais (ONGs). Desafios complexos foram solucionados nessa jornada, com acertos, erros e dores do crescimento. Entretanto, ainda era preciso definir o preço de um produto inovador, fundamental para democratizar o acesso das ONGs à plataforma digital. O caso da Simbiose Social pode ser utilizado para discutir temas práticos e acadêmicos relacionados a empreendedorismo, impacto social e inovação em cursos de graduação e de pós-graduação
Diários reflexivos como aliados da aprendizagem e da avaliação
Authors: Campana Carla
Published: May 2023

Objetivo: Explorar as contribuições de diários reflexivos para a aprendizagem e seu valor como instrumento de avaliação para a educação superior.Escopo: O artigo descreve a experiência de uso de diários reflexivos em um programa de formação integrada deum curso de graduação em Administração de Empresas. Trechos de diários produzidos por estudantes ilustram asdimensões reflexivas e demonstram o potencial do instrumento para avaliação formativa e diagnóstica.Originalidade: Aborda uma ferramenta não convencional no campo de ensino, aprendizagem e avaliaçãoeducacional em Administração.Relevância: Oferece subsídios a professores que desejem utilizar diários reflexivos como forma de contribuir paraa aprendizagem e/ou avaliação educacional.
Da maestria artística à maestria em sala de aula: aplicação de técnicas teatrais no ensino
Authors: De Lima Fleur A. , Flood Patrick C.
Published: May 2023

Objetivo: O objetivo deste artigo é fazer recomendações específicas para a aplicação de técnicas de teatro no ensino, contribuindo para experiências de aprendizagem envolventes e para um ensino eficaz no ensino superior.Escopo: Apresentamos três relatos de casos, baseados em nossa experiência na aplicação de técnicas teatrais em oficinas de desenvolvimento de professores realizadas em universidades, escolas de negócios e programas de desenvolvimento de lideranças.Originalidade: O artigo vai além de apenas tratar dos diferentes elementos teatrais separadamente, e foca na combinação dessas técnicas de forma que a soma seja maior que as partes.Relevância: Técnicas usuais da prática teatral podem ser aplicadas para fortalecer e ampliar a atuação docente e criar experiências de aprendizagem transferíveis.
Καινά δαιμόνια;
Authors: Δούκας Γιάννης
Published: May 2023

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A study protocol for investigating the effects of mobile phone-originated electromagnetic waves on thyroid gland and thyroid hormone activities in the brain
Authors: Zufry Hendra , Rudijanto Achmad , Soeatmadji Djoko Wahono , Sakti Setyawan Purnomo , Munadi Khairul , Sujuti Hidayat , Mintaroem Karyono
Published: May 2023

With widespread users across the globe, topic on the impact of mobile phone in particular regarding its electromagnetic wave radiation deserves a priority. Carcinogenic effects of the electromagnetic wave radiation have been suggested by multiple studies. Effects of the radiation are to involve thermal and non-thermal pathways. Among human organs, thyroid gland is susceptible to the radiation exposure due to its location being superficial and close to the radiation transmitter. Previous studies have indicated the correlation between the mobile phone radiation and thyroid dysfunctions. However, a conclusion that the electromagnetic wave radiation is the causative agent of the thyroid dysfunctions has not been reached. Most of the study are unable to remove the influence of the external electromagnetic wave radiation. Hence, this study aimed to perform an investigation with true experimental design using animal model in an anechoic chamber – an isolated chamber which could minimize the electromagnetic wave noise from the outside. In this article, we present the description of the anechoic chamber along with the research protocols. Parameters affecting the investigation, including signal frequencies inside the chamber and specific absorption rate are also measured.
Case Report: A very rare case of a pleural effusion revealing multiple myeloma
Authors: Daboussi Selsabil , Saidane Asma , Mhamdi Samira , Kacem Marwa , Essbaa Samia , Aichaouia Chiraz , Ghedira Hela , Gargouri Faten , Msakni Issam , Moatemri Zied
Published: May 2023

Multiple myeloma is a common malignant bone-based disease. Pleural effusions reported in these patients remain rare. It is commonly due to congestive heart disease, pulmonary embolism, nephrotic syndrome or a second neoplasia. The true myelomatous pleural effusion resulting from a direct tumoral invasion of the pleural are extremely rare. We report here the case of a massive pleural effusion revealing multiple myeloma in a 71-year-old patient. The chest ultrasound showed a massive pleural effusion in the left side with a multinodular thickening of the pleura. The medical thoracoscopy showed a grape-cluster appearance. The diagnosis was made by pleural guided biopsy revealing abnormal plasma cells with an intense positive CD 138 (plasma cell marker) and MUM1 (multiple myeloma oncogene1) staining with a light kappa chain in the protein electrophoresis associated with a myeloma. Unfortunately, our patient died one month after the initial diagnosis. We present also a review of the recent literature in order to highlight the clinical presentations of the myelomatous pleural effusion, the diagnostic tools, the therapeutic strategies as well as the outcomes.
Traumatic spinal spondyloptosis presenting in a tertiary care unit in central Nepal
Authors: Munakomi Sunil
Published: May 2023

Introduction: Traumatic spinal spondyloptosis, though rare, harbingers a high risk of mortality as well as permanent and disabling neurological deficits. They invariably become socially aloof and marginalized in most parts of our subcontinent owing to the lack of dedicated rehabilitation units amid their poor economic status. There is a paucity of studies pertaining to such rare epiphenomenon within our region.

Materials and Methods: A study of 16 patients presenting with spinal spondyloptosis from January 2017 to January 2023 in a tertiary care center in Nepal was undertaken. The clinical records of the patients were retrieved from the hospital record section to study the demographic variables, modes of injury, American Spinal Injury Association (ASIA) grades, salient radiological characteristics, management strategies, and the resultant clinical outcomes.

Result: The mean age of the cohorts in our study was 40 years with an age range of 25-80 years. Most of the patients presented in ASIA ‘A’ neurological grade (75%). The cervical spine was involved in the majority (68.75%) of cases. 8 (50%) patients left against medical advice, 2 (12.5%) were managed conservatively, and 6 (37.5%) were operated. The posterior-only approach was undertaken in 4(66.67%) cases. Tracheo-oesophageal fistula occurred in 2 (33.33%) patients. And cerebrospinal fluid (CSF) leak occurred in 2 (33.33%) patients. The overall hospital mortality was 3(37.5%). All the surviving patients were of the ASIA ‘E’ grades.

Conclusion: There is a continuum of physical, economic, psychological, and social burdens to both the patients and their care providers. Rehabilitation is the ‘bottleneck’ variable governing poor outcomes in our subcontinents. The poor economic status of the people has a ripple effect upon the same. This should also aid in the patient counseling as well as fostering the notion of the paramount need for dedicated neuro-rehabilitation units in our regions.
The more, the better: influence of family planning discussions during the maternal, newborn and child health continuum of care on postpartum contraceptive uptake and method type among young women in Ethiopia
Authors: Calhoun Lisa M. , Winston Jennifer , Beňová Lenka , Speizer Ilene S. , Delvaux Thérèse , Shiferaw Solomon , Seme Assefa , Karp Celia , Zimmerman Linnea , van den Akker Thomas
Published: May 2023

Background: This study examines the association between family planning (FP) discussions with health professionals during contact points on the maternal, newborn and child health continuum of care and timing of modern contraceptive uptake and method type in the one-year following childbirth in six regions of Ethiopia among adolescent girls and young women (AGYW).

Methods: This paper uses panel data of women aged 15-24 who were interviewed during pregnancy and the postpartum period between 2019-2021 as part of the PMA Ethiopia survey (n=652). 

Results: Despite the majority of pregnant and postpartum AGYW attending antenatal care (ANC), giving birth in a health facility, and attending vaccination visits, one-third or less of those who received the service reported discussion of FP at any of these visits. When considering the cumulative effect of discussions of FP at ANC, pre-discharge after childbirth, postnatal care and vaccination visits, we found that discussion of FP at a greater number of visits resulted in increased uptake of modern contraception by one-year postpartum. A greater number of FP discussions was associated with higher long-acting reversible contraceptive use relative to non-use and relative to short-acting method use.

Conclusions: Despite high attendance, there are missed opportunities to discuss FP when AGYW access care.
Cocreación de la Evaluación Mediada por Tecnología en Educación Superior: Perspectiva Docente.
Authors: Santana-Martel Jennifer Saray , Pérez Garcias Adolfina
Published: May 2023

Esta investigación indaga las percepciones que los profesores tienen sobre los procesos de cocreación de la evaluación en entornos de aprendizaje enriquecido por tecnología en educación superior. En este estudio cualitativo de casos múltiples se entrevistó a seis profesores (cuatro mujeres y dos hombres) y se analizaron los datos siguiendo el criterio inductivo-deductivo por medio de Atlas.ti. Este artículo presenta resultados relacionados con el nivel de participación de los/las estudiantes, el rol del alumnado y del profesorado, así como el papel de las TIC en procesos de cocreación y los aprendizajes que ambos agentes adquirieron en él. Del análisis cualitativo de los resultados, se infiere un rol más democrático en el profesorado y un rol activo en el alumnado. Igualmente, se percibe un aumento en el nivel de participación de los/as estudiantes. Además, los aprendizajes de los participantes de este proceso sacan a la luz algunos beneficios y limitaciones sobre la cocreación de la evaluación. Por un lado, se observa la adquisición de habilidades prácticas, de razonamiento y profesional por parte del alumnado. Asimismo, se percibe un aumento de la alfabetización en evaluación, la motivación y la empatía por parte de los mismos. Por otro lado, el profesorado expone el factor tiempo y organizacional como grandes limitantes del proceso de cocreación. Por último, se señala que esta investigación busca contribuir a la escasa literatura y no pretende generalizar sus resultados.
Inserção de profissionais de educação física no Sistema Único de Saúde: análise temporal (2007-2021)
Authors: Dutra Rinelly Pazinato , Viero Vanise dos Santos Ferreira , Knuth Alan Goularte
Published: May 2023

O objetivo desta pesquisa foi descrever e analisar a série temporal da inserção de profissionais de educação física (PEF) no Sistema Único de Saúde (SUS) no período de 2007 a 2021, bem como apresentar a distribuição por regiões e estados de profissionais no território brasileiro. Trata-se de um estudo descritivo e de série temporal que utilizou dados secundários oriundos do sistema de consultas do Cadastro Nacional dos Estabelecimentos de Saúde (CNES). Analisou-se o quantitativo de PEF no SUS nas cinco regiões e nos vinte e seis estados e no Distrito Federal entre 2007 e 2021 e realizou-se a análise temporal para verificar a distribuição dos PEF nas regiões brasileiras. Os resultados apontam para um crescimento no número de PEF entre 2007 (n = 22) e 2020 (n = 7.560) em todo o país. Em 2021 observa-se uma redução de 2,8% no quantitativo de PEF. Entre as regiões, os maiores quantitativos foram observados nas regiões Nordeste e Sudeste, enquanto nos estados a maior concentração foi em Minas Gerais, seguido de São Paulo, Pernambuco, Bahia e Rio Grande do Sul. Observou-se uma tendência crescente de PEF nas regiões Norte e Sul. Conclui-se que o quantitativo de PEF atuantes no SUS teve um crescimento expressivo durante o período analisado, sendo fruto das políticas públicas e programas voltados à promoção da atividade física constituídos ao longo do tempo. Apesar disso, há importantes disparidades geográficas que não devem ser desconsideradas, reforçando a necessidade de estratégias coletivas e investimentos em políticas públicas que fomentem a inserção dos PEF na rede assistencial e de fortalecimento do SUS.
Fluid Approximations for Revenue Management Under High-Variance Demand
Authors: Bai Yicheng , El Housni Omar , Jin Billy , Rusmevichientong Paat , Topaloglu Huseyin , Williamson David P.
Published: May 2023

One of the most prevalent demand models in the revenue management literature is based on dividing the selling horizon into a number of time periods such that there is at most one customer arrival at each time period. This demand model is equivalent to using a discrete-time approximation to a Poisson process, but it has an important shortcoming. If the mean number of customer arrivals is large, then the coefficient of variation of the number of customer arrivals has to be small. In other words, large demand volume and large demand variability cannot coexist in this demand model. In this paper, we start with a revenue management model that incorporates general mean and variance for the number of customer arrivals. This revenue management model has a random selling horizon length, capturing the distribution of the number of customer arrivals. The question we seek to answer is the form of the fluid approximation that corresponds to this revenue management model. It is tempting to construct the fluid approximation by computing the expected consumption of the resource capacities in the constraints and the total expected revenue in the objective function through the distribution of the number of customer arrivals. We demonstrate that this answer is wrong in the sense that it yields a fluid approximation that is not asymptotically tight as the resource capacities get large. We give an alternative fluid approximation where perhaps surprisingly, the distribution of the number of customer arrivals does not play any role in the constraints. We show that this fluid approximation is asymptotically tight as the resource capacities get large. A numerical study also demonstrates that the policies driven by the latter fluid approximation perform substantially better, so there is practical value in getting the fluid approximation right under high-variance demand.

This paper was accepted by Omar Besbes, revenue management and market analytics.

Funding: The work of the O. El Housni and H. Topaloglu was supported by a seed grant from Urban Tech research hub at Cornell Tech.

Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4769 .
New Mixed-Integer Nonlinear Programming Formulations for the Unit Commitment Problems with Ramping Constraints
Authors: Bacci Tiziano , Frangioni Antonio , Gentile Claudio , Tavlaridis-Gyparakis Kostas
Published: May 2023

Mixed-Integer Formulations for Power Production Problems

The unit commitment problem is a complex mixed-integer nonlinear program that originates in the field of power production. Although it arises in a monopolistic system, there is still great attention to this problem even in a free-market regime, where it constitutes only a subproblem of larger ones. Historically, it was usually solved by Lagrangian relaxation methods. However, the advances achieved by commercial solvers of mixed-integer (linear and convex) programming problems have made such approaches an attractive option. T. Bacci, A. Frangioni, C. Gentile, and K. Tavlaridis-Gyparakis present the first mixed-integer nonlinear programming formulation with a polynomial number of both variables and constraints that describes the convex hull of the feasible solutions of the unit commitment problem with a single thermal generation unit, comprising all typical constraints and convex power generation costs. Proving that the formulation is exact requires a new result about the convex envelope of specially structured functions that can have independent interest. This new formulation for a single power generation unit is used to derive three new formulations for the general unit commitment problem whose effectiveness has been tested against the state-of-art formulation.
Survey of Dynamic Resource-Constrained Reward Collection Problems: Unified Model and Analysis
Authors: Balseiro Santiago R. , Besbes Omar , Pizarro Dana
Published: May 2023

Dynamic resource allocation problems arise under a variety of settings. In “Survey of Dynamic Resource-Constrained Reward Collection Problems: Unified Model and Analysis,” Balseiro, Besbes, and Pizarro introduce a unifying model for a large class of dynamic optimization problems dubbed dynamic resource-constrained reward collection (DRC2) problems. Surveying the literature, they show that this class encompasses a variety of disparate and classical problems typically studied separately, such as dynamic pricing with capacity constraints, dynamic bidding with budgets, network revenue management, online matching, or order fulfillment. Furthermore, they establish that the DRC2 class is amenable to analysis by characterizing the performance of a central, certainty-equivalent heuristic. Notably, they provide a novel unifying analysis that isolates the drivers of performance, recovers as corollaries some existing specialized results, generalizes other existing results by weakening the assumptions required, and yields new results in specialized settings for which no such characterization was available.
Petangan Jawa: Installing traditional values in names
Authors: Tur Ajar Pradika Ananta , Munandar Aris , Winarti Daru
Published: May 2023

This research contributes to investigate a cultural continuity, particularly naming practice, in a homogenous Javanese community installing Petangan Jawa (Javanese Calculations). However, common Javanese slowly ignore it. This study employs a descriptive qualitative approach with fieldwork to investigate the intention behind the name. Therefore, two varieties of Petangan Jawa, namely, a calculation based on calendar properties and a calculation based on Javanese script values, are still consistently used. In addition, this study paves the way for future research on the causes of the gradual abandonment of Petangan Jawa among common Javanese and how the perspective of religious beliefs about Petangan Jawa is used to predict the future.
Between housewifery and emancipation in My Lecturer My Husband novel by Gitlicious
Authors: Apriyani Tristanti , Lixian Xiao
Published: May 2023

This study aims to examine the actualization of women in the novel My Lecturer My Husband by Gitlicious by relying on the formulation put forward by Betty Friedan. The depiction of the minimal role of women in literary production means that female characters in literary works are often portrayed as biased and one-sided. Therefore, it is essential to discuss women's experiences through women authors' works because they have direct experience in describing women's lives. This research is a type of qualitative descriptive research that uses documentation techniques and literature studies as a data collection method. Meanwhile, the data analysis technique used was interactive, including data reduction techniques, presentation, and verification. This study shows that women experience an identity crisis because they often surrender to the situation. Circumstances that require Inggit's character to be at a certain point so that she feels have to return to their nature.
Assessment of Contamination Potential in Okhla Landfill, New Delhi by using Leachate Pollution Index
Authors: ANGMO SONAM , Kharayat Yogita , Shah Shachi
Published: May 2023

Landfill leachate generation from a landfill site is one of the main problems for both developed and developing countries around the world. Leachates liberated from the site contain various organic, inorganic, heavy metals, and sometimes hazardous chemical and organic pollutants, which are the origin of the deterioration of air and water quality in its vicinity. The present attempt was performed to assess seasonal variation of the leachate quality, and also determine three sub-indices of leachate which are LPIorg, LPIin, and LPIhm, and the overall LPI of operational, uncontrolled landfills in South Delhi by using leachate pollution index (LPI). Around twenty-five (25) parameters were analyzed during pre-monsoon, monsoon, and post-monsoon seasons from the collected leachate samples. Out of twenty-five pollutants, COD, BOD, NH4-N, EC, and TDS were found beyond the set standard limit in all seasons. Other pollutants like TKN, TSS, TCB, and Cl were also found in high concentrations. Arsenic (As) concentration was found beyond permissible during post-monsoon. The concentration of lead (Pd) in the pre and post-monsoon season was observed beyond the standard limit. Sub-LPI indices in the pre-monsoon season were observed as LPIorg 82.0, LPIin 40.8, and LPIhm 6.9, and likewise, Sub-LPI in monsoon season were LPIorg 81.4, LPIin 25.5, and LPIhm 5.2 and Sub-LPI post-monsoon season was calculated as LPIorg 90.5, LPIin 30.2 and LPI hm 6.2. Almost in all the seasons, LPIorg i.e. organic pollutants was dominated then followed by LPIin, and LPIhm. The overall LPI value of the study area during the pre-monsoon, monsoon and post-monsoon was 32.5, 28.2 and 32.0, respectively. It was observed that overall LPI (calculated) was maximum during pre-monsoon followed by post-monsoon and monsoon. LPI value was beyond the standard limit, except for LPI hm, which was below the standards. It was recommended that more waste-to-energy plants and decentralized waste segregation units need to be set up, to avoid direct dumping of all mixed waste in the landfill sites.