bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing the Reliability of the Sexual Violence Questionnaire in Sport among Spanish-Speaking Athletes
Authors: Sáenz-Olmedo Andrea , Iturricastillo Aitor , Brain Jon , Zulaika Luis Maria , Usabiaga Oidui
Published: September 2024

The prevalence of sexual harassment and abuse in school sport, specifically by coaches against their athletes, remains a concerning and pervasive issue. In an attempt to better understand and prevent specific coach-behaviours associated with such sexual misconduct, researchers have developed the Sexual Violence Questionnaire in Sport. While the reliability of this measurement tool has been tested in Anglo-Saxon cultural contexts, it is not known whether the questionnaire is applicable to other cultural contexts. This study aimed to analyse the internal consistency and reliability of the questionnaire on sexual harassment in sport, originally designed and developed in English. A sample of 146 (52 female, 94 male) undergraduate students from a university in the Basque Country participated in this cross-sectional study. The questionnaire was administered twice over a two-week period to assess test–retest reliability. The internal consistency of the Sexual Violence Questionnaire in Sport was high, with Cronbach’s alpha values of 0.891 for perceptions and 0.813 for experiences across all participants. Gender-specific analysis showed similar reliability, with females having slightly lower alpha values for perceptions. Although significant differences were observed between the test and the retest on eight perception items and one experience item, Cohen’s kappa analysis indicated agreement on all items; however, some of them were low (e.g., 0.13). In conclusion, the study highlights the questionnaire’s overall reliability and suggests its effectiveness as a tool for measuring sexual violence in sport within the Spanish context. Nonetheless, the findings of this study underscore the need for further research to enhance the instrument’s stability and to better understand gender differences in perceptions and experiences of sexual violence in sport contexts.
Exploring General Practitioners’ Knowledge, Attitudes, and Practices towards E-Cigarette Use/Vaping in Children and Adolescents: A Pilot Cross-Sectional Study in Sydney
Authors: Singh Rajiv , Burke Michael , Towns Susan , Rahman Muhammad Aziz , Bittoun Renee , Shah Smita , Liu Anthony , Bhurawala Habib
Published: September 2024

(1) Background: The increasing use of e-cigarettes/vaping in children and adolescents has been recognised as a global health concern. We aim to explore the Knowledge, Attitude, and Practice of General Practitioners (GPs) in Sydney regarding the use of e-cigarettes in children and adolescents and identify the barriers to addressing this issue. (2) Methods: This pilot study was a cross-sectional study conducted using an electronic questionnaire with a Likert scale and free-text responses. (3) Results: Fifty-three GPs participated in the study (male = 24 and female = 29) with a mean age of 50 ± 5.5 years. There was strong agreement (mean 4.5) about respiratory adverse effects and addictive potential. However, there was less awareness of cardiac side effects and the occurrence of burns. There is a lack of conversation about e-cigarettes in GP practice and a deficit of confidence in GPs regarding managing e-cigarette use in children and adolescents. (4) Conclusions: Our pilot study has shown that GPs are somewhat knowledgeable about the potential adverse effects of the use of e-cigarettes in children and adolescents, though there is a lack of knowledge of the complete spectrum of adverse effects and more importantly, there is a paucity of a structured approach to discuss the use of e-cigarettes with children and adolescents, and there is a low level of confidence in addressing these issues. There is a need for educational interventions for GPs to increase awareness of the potential adverse effects of using e-cigarettes and build confidence in providing management to children and adolescents regarding the use of e-cigarettes.
Seasonal Abundance and Diversity of Culicoides Biting Midges in Livestock Sheds in Kanchanaburi Province, Thailand
Authors: Thepparat Arunrat , Kamata Naoto , Siriyasatien Padet , Prempree Waranya , Dasuntad Kannika , Chittsamart Boonruam , Sanguansub Sunisa
Published: September 2024

Culicoides biting midges were collected using UV light traps from nine livestock farms in Kanchanaburi Province, Thailand. Collections were made one night per month from June 2020 to May 2021 to determine the seasonal changes and spatial distribution of the Culicoides assemblage. The influence of four environmental factors (temperature, rainfall, humidity, and wind speed), types of animals in each shed (cattle, pigs, and avians), and neighboring animals (those in the other sheds and their proximity) were assessed. A subsample of 130,670 out of a total of 224,153 specimens collected was identified and counted. The collections were predominantly female (76.9%), though males were also commonly collected (23.1%). The dominant species included C. peregrinus (97,098 individuals; 43.0%), C. oxystoma (55,579; 24.6%), C. arakawae (45,996; 20.4%), and C. imicola (15,703; 7.0%), while other species accounted for the remaining 9777 individuals (4.4%). Trap captures were strongly influenced by seasons and animal sheds. Cattle exhibited the greatest effect on the community, likely due to their large biomass. Humidity and temperature had a positive effect on trap captures, whereas wind speed exhibited a negative effect. Cattle positively influenced all major species, except for C. arakawae, which showed a positive association with avians. A “neighboring effect” was also observed. Additionally, the lowest dispersal ability of C. arakawae was suggested.
Laparoscopic Fertility-Sparing Management of Borderline Ovarian Tumors: Surgical and Long-Term Oncological Outcomes
Authors: Tortajada Valle Marta , Agustí Núria , Fusté Pere , Mensión Eduard , Díaz-Feijóo Berta , Glickman Ariel , Marina Tiermes , Torné Aureli
Published: September 2024

Objectives: To assess the long-term oncological safety of laparoscopic fertility-sparing surgery (FSS) in borderline ovarian tumors and the impact of laparoscopic surgical factors on recurrences. Primary outcomes were the recurrence rate and time to recurrence after laparoscopic FSS. Secondary outcomes were to evaluate the recurrence rate after a second laparoscopic surgery and to assess factors associated with the risk of relapse. Methods: This is a retrospective single-center observational study in a tertiary university-affiliated hospital. Thirty-four patients diagnosed with borderline ovarian tumors who underwent laparoscopic FSS were recruited. Patients were categorized into two groups: the adnexectomy group, including patients who underwent unilateral adnexectomy, and the cystectomy group, which included patients who underwent unilateral cystectomy, bilateral cystectomy, and unilateral adnexectomy with contralateral cystectomy. Results: Eleven relapses (32.3%) were observed during a median follow-up period of 116.1 [62.5–185.4] months. The recurrence rate was similar for patients who underwent cystectomy (6/19, 31.6%) and adnexectomy (5/15, 33.3%). Cystectomy led to a shorter time to first recurrence (36-month progression-free survival rates of 66% vs. 85%) and higher rates of capsular rupture (71.4% vs. 20%, p = 0.04) compared to adnexectomy. No deaths due to progression of disease were reported. Conclusions: Laparoscopic FSS for borderline ovarian tumors is a safe, long-term oncological option. Although the recurrence rate was similar in patients undergoing adnexectomy or cystectomy, the time to recurrence was shorter in cases treated with cystectomy. Further research is needed to identify eventual laparoscopic risk factors more strongly correlated with recurrence.
Challenges in Contemporary Spine Surgery: A Comprehensive Review of Surgical, Technological, and Patient-Specific Issues
Authors: Mensah Emmanuel O. , Chalif Joshua I. , Baker Jessica G. , Chalif Eric , Biundo Jason , Groff Michael W.
Published: September 2024

Spine surgery has significantly progressed due to innovations in surgical techniques, technology, and a deeper understanding of spinal pathology. However, numerous challenges persist, complicating successful outcomes. Anatomical intricacies at transitional junctions demand precise surgical expertise to avoid complications. Technical challenges, such as underestimation of the density of fixed vertebrae, individual vertebral characteristics, and the angle of pedicle inclination, pose additional risks during surgery. Patient anatomical variability and prior surgeries add layers of difficulty, often necessitating thorough pre- and intraoperative planning. Technological challenges involve the integration of artificial intelligence (AI) and advanced visualization systems. AI offers predictive capabilities but is limited by the need for large, high-quality datasets and the “black box” nature of machine learning models, which complicates clinical decision making. Visualization technologies like augmented reality and robotic surgery enhance precision but come with operational and cost-related hurdles. Patient-specific challenges include managing postoperative complications such as adjacent segment disease, hardware failure, and neurological deficits. Effective patient outcome measurement is critical, yet existing metrics often fail to capture the full scope of patient experiences. Proper patient selection for procedures is essential to minimize risks and improve outcomes, but criteria can be inconsistent and complex. There is the need for continued technological innovation, improved patient-specific outcome measures, and enhanced surgical education through simulation-based training. Integrating AI in preoperative planning and developing comprehensive databases for spinal pathologies can aid in creating more accurate, generalizable models. A holistic approach that combines technological advancements with personalized patient care and ongoing education is essential for addressing these challenges and improving spine surgery outcomes.
Impact of Atrial Fibrillation with Rapid Ventricular Response on Atrial Fibrillation Recurrence: From the CODE-AF Registry
Authors: Jeong Joo Hee , Baek Yong-Soo , Park Junbeom , Park Hyung Wook , Choi Eue-Keun , Park Jin-Kyu , Kang Ki-Woon , Kim Jun , Lee Young Soo , Kim Jin-Bae , Choi Jong-Il , Joung Boyoung , Shim Jaemin
Published: September 2024

Background/Objectives: Relatively little has been established about the association of rapid ventricular response (RVR) with further recurrence of atrial fibrillation (AF). This study investigated the impact of RVR on the recurrence of AF. Methods: Data were obtained from a multicenter, prospective registry of non-valvular AF patients. RVR was defined as AF with a ventricular rate > 110 bpm. The primary endpoint was the recurrence of AF, defined as the first AF detected on 12-lead electrocardiography during follow-up. Secondary endpoints included manifestation of AF during follow-up and major adverse cardiovascular events (MACEs), a composite of thromboembolic events, major bleeding, myocardial infarction, and death. Results: Among 5533 patients, 493 (8.9%) presented RVR. Patients with RVR were younger, had smaller left atrial diameters, and more frequently had paroxysmal AF. During the mean follow-up duration of 28.6 months, the RVR group exhibited significantly lower recurrence of AF (hazard ratio: 0.58, 95% confidence interval: 0.53–0.65, p < 0.001). There was no significant difference in the occurrence of MACEs between patients with RVR and those without RVR (0.96, 0.70–1.31, p = 0.800). AF with RVR was identified as an independent negative predictor of AF recurrence (0.61, 0.53–0.71, p < 0.001). Conclusions: In patients with AF, those with RVR had a significantly lower recurrence of AF without an increase in MACEs. RVR is a favorable marker that may benefit from early rhythm control.
Are Sleep Parameters and Chronotype Associated with Eating Disorder Risk? A Cross-Sectional Study of University Students in Spain
Authors: Martins-de-Passos Tomás Olivo , Mesas Arthur E. , Beneit Nuria , Díaz-Goñi Valentina , Peral-Martinez Fernando , Cekrezi Shkelzen , Martinez-Vizcaino Vicente , Jimenez-Lopez Estela
Published: September 2024

Objectives: Eating disorders (EDs) have emerged as a growing public health concern. However, the role of sleep in this context remains underexplored. The aim of this cross-sectional study was to determine the associations between sleep parameters and chronotype with ED risk in a sample of university students in Spain. Methods: ED risk was assessed via the Sick, Control, One stone, Fat, Food Questionnaire, and sleep quality was assessed via the Pittsburgh Sleep Quality Index. Other sleep parameters and chronotypes were self-reported. Sociodemographic, body composition, lifestyle, and depressive symptom data were collected. Logistic and linear regression models adjusted for the main confounders were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the study associations. Results: A total of 403 students (70.2% female) aged 18 to 30 years participated in the study. Those reporting poor sleep quality (OR = 1.85, 95% CI 1.08–3.17, p = 0.025) and ≤6 h of night-time sleep duration (OR = 4.14, 95% CI 2.00–8.57, p < 0.01) were more likely to be at risk of EDs in the adjusted analyses. The association between night-time sleep duration and the risk of ED did not remain significant when we adjusted for sleep quality. In addition, an evening chronotype was associated with an increased risk of EDs (OR = 1.68, 95% CI 1.07–2.66, p = 0.039) only before adjustment for confounders. Conclusions: Among university students, poorer sleep quality was cross-sectionally associated with EDs. Future prospective studies are needed to examine whether promoting sleep quality may serve as an effective strategy for preventing the risk of EDs.
Management of Myocardial Infarction and the Role of Cardiothoracic Surgery
Authors: Parness Shannon , Tasoudis Panagiotis , Agala Chris B. , Merlo Aurelie E.
Published: September 2024

Myocardial infarction (MI) is a leading cause of mortality globally and is predominantly attributed to coronary artery disease (CAD). MI is categorized as ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI), each with distinct etiologies and treatment pathways. The goal in treatment for both is restoring blood flow back to the myocardium. STEMI, characterized by complete occlusion of a coronary artery, is managed urgently with reperfusion therapy, typically percutaneous coronary intervention (PCI). In contrast, NSTEMI involves a partial occlusion of a coronary artery and is treated with medical management, PCI, or coronary artery bypass grafting (CABG) depending on risk scores and clinical judgment. The Heart Team approach can assist in deciding which reperfusion technique would provide the greatest benefit to the patient and is especially useful in complicated cases. Despite advances in treatment, complications such as cardiogenic shock (CS) and ischemic heart failure (HF) remain significant. While percutaneous coronary intervention (PCI) is considered the primary treatment for MI, it is important to recognize the significance of cardiac surgery in treatment, especially when there is complex disease or MI-related complications. This comprehensive review analyzes the role of cardiac surgery in MI management, recognizing when it is useful, or not.
Bridging Behavior of Palm Fiber in Cementitious Composite
Authors: Abrha Selamawit Fthanegest , Shiferaw Helen Negash , Kanakubo Toshiyuki
Published: September 2024

This study addresses the growing need for sustainable construction materials by investigating the mechanical properties and behavior of palm fiber-reinforced cementitious composite (FRCC), a potential eco-friendly alternative to synthetic fiber reinforcements. Despite the promise of natural fibers in enhancing the mechanical performance of composites, challenges remain in optimizing fiber distribution, fiber–composite bonding mechanism, and its balance to matrix strength. To address these challenges, this study conducted extensive experimental programs using palm fiber as reinforcement, focusing on understanding the fiber–matrix interaction, determining the pullout load–slip relationship, and modeling fiber bridging behavior. The experimental program included density calculations and scanning electron microscope (SEM) analysis to examine the surface morphology and diameter of the fibers. Single fiber pullout tests were performed under varying conditions to assess the pullout load, slip behavior, and failure modes of the palm fiber, and a relationship between the pullout load and slip with the embedded length of the palm fiber was constructed. A trilinear model was developed to describe the pullout load–slip behavior of single fibers, and a corresponding palm-FRCC bridging model was constructed using the results from these tests. Section analysis was conducted to assess the adaptability of the modeled bridging law calculations, and the analysis result of the bending moment–curvature relationship shows a good agreement with the experimental results obtained from the four-point bending test of palm-FRCC. These findings demonstrate the potential of palm fibers in improving the mechanical performance of FRCC and contribute to the broader understanding of natural fiber reinforcement in cementitious composites.
Impact of Calcium Lactate Pretreatment on Enamel Fluoride Uptake: A Comparative In Vitro Study of Different Fluoride Types and Concentrations
Authors: Kullashi Spahija Fjolla , Sutej Ivana , Basic Kresimir , Spahija Kreshnik , Peros Kristina
Published: September 2024

(1) Background: This study aimed to establish the effect of calcium lactate enamel pretreatment related to different fluoride types and concentrations on the enamel uptake of alkali-soluble fluorides. (2) Materials: In a blind and randomized in vitro study, a total of 60 teeth are used. The first 30 teeth were cut and randomly allocated into one of the following treatments: (A) calcium lactate pretreatment followed by three different fluoride solutions; (B) the “Fluoride only” group, with slabs treated with three different fluoride solutions; (C) the “Calcium only” group, with slabs treated with calcium lactate solution; (D) slabs treated with deionized water (negative control group). The next 30 teeth underwent all the above described group procedures but were treated with lower fluoride concentrations. Fluoride was extracted from enamel using 1 M KOH solution and analyzed using a fluoride ion-specific electrode. (3) Results: The findings revealed that slabs treated with NaF following calcium lactate pretreatment exhibited significantly greater enamel uptake of alkali-soluble fluoride compared to other substrates. This significant effect was not observed at lower fluoride concentrations. (4) Conclusion: The study demonstrates that pretreatment with calcium lactate followed by treatment with NaF at 226 ppm F significantly enhances the uptake of alkali-soluble fluoride in enamel compared to other fluoride types.
Evolution Process and Land Use/Land Cover Response of Urban–Rural Space in Wuhan under Polycentric Structure
Authors: Yan Jisheng , Ye Jing
Published: September 2024

Polycentric development facilitates urban–rural spatial reshaping and land use/land cover (LULC) protection. Previous studies have predominantly focused on urban areas, with spatial delineation methods biased towards the macro-level, lacking a holistic perspective that situates them within the urban–rural spatial framework. This study proposes a spatial delineation framework that is applicable to the polycentric structure, taking into account the social, economic, and natural characteristics of urbanization. It employs semivariance analysis and spatial continuous wavelet transform (SCWT) to analyze the effects of polycentric development on the urban–rural space of Wuhan from 2012 to 2021 and applies a land use transition matrix, landscape indices, and bivariate spatial autocorrelation to quantify the responses and differences of LULC within urban–rural space. The results indicate that 600m×600m is the best scale for exhibiting the multidimensional characterization of urbanization. The polycentric structure alleviates the compact development of the central city, and it drives rapid expansion at the urban–rural fringe, exacerbating the spatial heterogeneity in LULC change pattern, spatial configuration, and urbanization response within urban–rural spaces. The overall effects of urbanization on LULC are relatively weak along the urban–rural gradient, experiencing a transition from positive to negative and back to positive. This study employs a novel spatial delineation framework to depict the polycentric transformation of metropolitan areas and provides valuable insights for regional planning and ecological conservation in the urban–rural fringe.
Managing the Supply–Demand Mismatches and Potential Flows of Ecosystem Services in Jilin Province, China, from a Regional Integration Perspective
Authors: Jin Xinyue , Wang Jianguo , Liu Daping , Li Shujie , Zhang Yi , Wang Guojian
Published: September 2024

Regional integration strategically reorganizes spatially heterogeneous resources to maximize the overall benefits. Ecosystem services (ESs) are promising targets for regional integration due to their inherent heterogeneity and mobility, yet research in this area remains limited. This study quantifies crop production (CP), water yield (WY), carbon storage (CS), and habitat quality (HQ) for the years 2000, 2010, and 2020 using the InVEST model and identifies four ES bundles through a K-means cluster analysis. A conceptual ecosystem service flow (ESF) network at the service cluster scale is constructed based on county-level ESF data. The results reveal the following: (1) there is an upward trend in the ES budget for all services from 2000 to 2020, coupled with spatial mismatches between supply and demand; (2) deficit nodes for CP and CS services are concentrated in densely populated districts, while deficits in WY and HQ services are mainly in western Jilin Province; (3) Bundles I and II act as “sources” of ES, Bundle IV serves as a “sink”, and Bundle III is the only cluster with a CP surplus, balancing CP services across the province. In addition, this study provides ecological perspectives for understanding regional integration by suggesting differentiated integrated management for different ecosystem bundles.
Utilization of Assisted Reproductive Technologies in Breeding Auliekol Cattle: A Comparative Study
Authors: Kulpiisova Altyn , Yessengaliyev Kairly , Kassimova Gulsara , Kozhakhmetova Ainat , Kadraliyeva Bakytkanym , Rustem Abeldinov , Temirzhanova Alma , Burambayeva Nadezhda , Chylbak-ool Salbak , Pakhomova Elena , Abekeshev Nurzhan , Baikadamova Gulnara , Kemeshev Zhomart , Tegza Alexandra , Issimov Arman , White Peter
Published: September 2024

This study evaluates the utilization of in vitro embryo production (IVEP) technology for the conservation and breeding of the Auliekol cattle breed, a primary beef breed in Kazakhstan facing population decline due to the cessation of breeding programs and the incursion of transboundary diseases. We assessed the effect of consecutive ovum pick-up (OPU) procedures on oocyte yield and embryo production in Auliekol and Aberdeen Angus cows. A total of 2232 and 3659 oocytes were aspirated from Auliekol and Aberdeen Angus donors, respectively, with significantly higher yields and embryo production observed in Aberdeen Angus cows. The application of a meiotic block using Butyrolactone I (BLI) and subsequent in vitro fertilization (IVF) protocols was employed, with embryo development monitored up to the morula/blastocyst stage. Results indicated that Auliekol cows exhibited lower oocyte recovery, cleavage, and blastocyst rates compared to Aberdeen Angus cows, likely due to genetic characteristics. Despite the challenges, IVEP presents a valuable tool for the preservation and future propagation of the Auliekol breed, highlighting the need for further research to enhance reproductive outcomes and conservation strategies.
Endovascular Therapy of Ruptured Aneurysms on Moyamoya Collateral Vessels: Two Cases
Authors: Ryška Pavel , Lojík Miroslav , Habalová Jiřina , Kajzrová Carmen , Česák Tomáš , Vítková Eva , Bartoš Michael , Bělobrádek Zdeněk , Krajina Antonín
Published: September 2024

Background: Using two case reports of adult women with moyamoya disease presenting with intracranial hemorrhage from ruptured aneurysms on moyamoya collateral vessels, we aim to demonstrate the potential for effective endovascular treatment navigated by CT angiography, digital subtraction angiography, and flat panel CT. Case 1 Presentation: A 45-year-old female patient with sudden onset of headache, followed by somnolency. CT scan showed a four-ventricle hematocephalus caused by a 27 × 31 × 17 mm hematoma located in the left basal ganglia. Angiography revealed a 3 mm aneurysm on hypertrophic lenticulostriate artery bridging the M1 occlusion. Selective catheterization and distal embolisation with acrylic glue was done. Case 2 Presentation: A 47-year-old woman was admitted for a sudden onset of severe headache, CT scan showed four-ventricle hematocephalus. A 4 mm aneurysm on the collateral vessel–anterior chorioidal artery bridging the closure of the terminal segment of the internal carotid artery was diagnosed as the source of bleeding. Selective catheterization and distal embolisation with acrylic glue was done. Conclusions: Selective embolisation of ruptured aneurysms on moya moya collaterals is a simple, effective, and safe procedure when relevant microcatheters are used with imaging software navigation such as 3D DSA, 3D road map and flat-panel CT.
Perforator Selection with Computed Tomography Angiography for Unilateral Breast Reconstruction: A Clinical Multicentre Analysis
Authors: Seth Ishith , Lim Bryan , Phan Robert , Xie Yi , Kenney Peter Sinkjær , Bukret William E. , Thomsen Jørn Bo , Cuomo Roberto , Ross Richard J. , Ng Sally Kiu-Huen , Rozen Warren M.
Published: September 2024

Background and Objectives: Despite CTAs being critical for preoperative planning in autologous breast reconstruction, experienced plastic surgeons may have differing preferences for which side of the abdomen to use for unilateral breast reconstruction. Large language models (LLMs) have the potential to assist medical imaging interpretation. This study compares the perforator selection preferences of experienced plastic surgeons with four popular LLMs based on CTA images for breast reconstruction. Materials and Methods: Six experienced plastic surgeons from Australia, the US, Italy, Denmark, and Argentina reviewed ten CTA images, indicated their preferred side of the abdomen for unilateral breast reconstruction and recommended the type of autologous reconstruction. The LLMs were prompted to do the same. The average decisions were calculated, recorded in suitable tables, and compared. Results: The six consultants predominantly recommend the DIEP procedure (83%). This suggests experienced surgeons feel more comfortable raising DIEP than TRAM flaps, which they recommended only 3% of the time. They also favoured MS TRAM and SIEA less frequently (11% and 2%, respectively). Three LLMs—ChatGPT-4o, ChatGPT-4, and Bing CoPilot—exclusively recommended DIEP (100%), while Claude suggested DIEP 90% and MS TRAM 10%. Despite minor variations in side recommendations, consultants and AI models clearly preferred DIEP. Conclusions: Consultants and LLMs consistently preferred DIEP procedures, indicating strong confidence among experienced surgeons, though LLMs occasionally deviated in recommendations, highlighting limitations in their image interpretation capabilities. This emphasises the need for ongoing refinement of AI-assisted decision support systems to ensure they align more closely with expert clinical judgment and enhance their reliability in clinical practice.
Prognostic Significance of Lactate Clearance in Cardiogenic Pulmonary Edema in the Emergency Department
Authors: Efgan Mehmet Göktuğ , Bora Ejder Saylav , Kayalı Ahmet , Payza Umut , Duman Şahan Tutku , Karakaya Zeynep
Published: September 2024

Background and Objectives: Acute cardiorespiratory failure disrupts the delicate balance of energy supply, demand, and consumption, with elevated lactate levels and decreased blood pH serving as crucial indicators. Acute cardiogenic pulmonary edema (ACPO), a common cause of acute respiratory failure, poses a substantial mortality risk. Lactate, a byproduct of pyruvate reduction, is a pertinent marker in perfusion assessment. Lactate clearance (LC) has proven prognostic efficacy in various conditions but lacks consensus on its predictive power in acute cardiogenic pulmonary edema. Materials and Methods: This prospective observational study, conducted in a metropolitan area’s third-level emergency department, involved patients with cardiogenic pulmonary edema from May 2021 to August 2023. The inclusion criteria specified acute cardiogenic pulmonary edema, excluding patients with incomplete data or other respiratory conditions. Lactate clearance, calculated at presentation and after 6 h, served as the primary outcome predictor. Our data analysis employed logistic regression, the ROC curve, and statistical tests. Results: The cohort of 106 patients revealed that a lactate clearance below 14.29% was significantly associated with mortality. While 51.6% of survivors were discharged, LC’s predictive success for discharge was inconclusive. Logistic regression underscored the significance of lactate clearance, with a one-unit increase yielding a 5.55-fold probability of survival. The AUC for LC was 0.759. Conclusions: This study pioneers the exploration of lactate clearance in patients with acute cardiogenic pulmonary edema. LC below 14.29% signifies a poor prognosis, emphasizing its potential as an early treatment initiation marker. While acknowledging this study’s limitations, we advocate for further multicenter research to refine the understanding of lactate clearance in this context.
Relationship between Cancer and Intention to Leave Work among Older Workers: A Cross-Sectional Internet-Based Study
Authors: Matsugaki Ryutaro , Matsuda Shinya , Ogami Akira
Published: September 2024

Background and Objectives: Limited research has focused on the relationship between cancer, job loss, and factors associated with job loss among older workers. Therefore, in this study, we aimed to examine the relationship between cancer and intention to leave and between physical-health-related issues, mental-health-related issues, and cancer-related symptoms and intention to leave among older workers with cancer. Materials and Methods: This cross-sectional internet-based study included 4498 workers aged 60–75 years. Intention to leave was assessed based on whether individuals considered quitting their current jobs in the near future. Results: A multivariate logistic regression analysis showed a significant association between cancer and intention to leave (adjusted odds ratio [aOR]: 1.42, 95% confidence interval [CI]: 1.01–2.00, p = 0.045). In addition, physical-health-related issues (aOR: 2.33, 95% CI: 1.10–4.92, p = 0.026) and mental-health-related issues (aOR: 4.44, 95% CI: 1.80–10.98, p = 0.001) were significantly associated with the intention to leave. Conclusions: Healthcare providers and employers must address the physical- and mental-health-related issues facing older workers with cancer to help them secure their employment.
The Influence of the Combined Addition of La–Ce Mixed Rare Earths and Sr on the Microstructure and Mechanical Properties of AlSi10MnMg Alloy
Authors: Liu Yu , Yu Zhichao , Zhang Man , Feng Qisheng , Zhang Dong , Gao Pengyue , Li Chonghe
Published: September 2024

This study investigated the effect of adding La–Ce mixed rare earths and Sr on the microstructure and mechanical properties of AlSi10MnMg alloy. The experiment utilized different combinations of modifiers, including single La–Ce rare earths, single Sr, and the combined addition of La–Ce mixed rare earths and Sr. This study compared their effects on grain refinement, the modification of the α-Al phase and eutectic silicon phase, and tensile properties and hardness. The results showed that the combined modification of Sr and mixed rare earth elements significantly refined the grains, optimized the morphology of the α-Al phase and eutectic silicon phase, and improved the overall mechanical properties of the aluminum alloy. Under the combined modification, the addition of 0.02 wt.% Sr and 0.1 wt.% RE (La–Ce mixed rare earths) exhibited the most pronounced refining effect. The secondary dendrite arm spacing (SDAS) was reduced by 59.18%. The eutectic silicon phase transformed from coarse needle-like shapes to fine fibrous or granular forms, with an aspect ratio reduction of 69.39%. Meanwhile, the alloy’s tensile strength and hardness were significantly improved. The tensile strength increased to 240 MPa, achieving an increase of 23.08%; the yield strength increased to 111 MPa, achieving an increase of 18.09%; and the elongation reached 7.3%, achieving an increase of 73.81%. This indicates that the proper addition of Sr and mixed rare earths can significantly optimize the microstructure and enhance the mechanical properties of AlSi10MnMg alloy, providing an effective method for the preparation of high-performance heat-treatment-free aluminum alloys.
Feature Papers in Metal Matrix Composites
Authors: Gupta Manoj
Published: September 2024

Metal matrix composites (MMCs) are dynamic and fascinating materials as they can be designed to suit the end property requirements for any present and futuristic application [...]
Investigations on the Heat Balance of the Melt Pool during PBF-LB/M under Various Process Gases
Authors: Baehr Siegfried , Fritz Fabian , Adami Stefan , Ammann Thomas , Adams Nikolaus A. , Zaeh Michael F.
Published: September 2024

During the powder bed fusion of metals using a laser beam (PBF-LB/M), an inert atmosphere is maintained in the build chamber to avoid reactions of the liquid metal with ambient air leading to the creation of oxides or nitrides, which alter the mechanical properties of the processed part. A continuous gas flow is guided over the process zone to remove spatters and fumes. This flow induces a convective heat transfer from the molten metal to the gas, which, depending on the level of the heat flow, may alter the melt pool dimensions by influencing the cooling rate. The present work investigated these phenomena with single-line trials, both experimentally and numerically. For this reason, a smoothed-particle hydrodynamics model was utilized to investigate the temperatures of the melt pool, cooling rates, and the integral heat balance with various gas atmospheres. In parallel, an on-axis pyrometer was set up on an experimental PBF-LB/M machine to capture the surface emissions of the melt pool. The atmosphere in the simulations and experiments was varied between argon, helium, and two mixtures thereof. The results showed a slight increase in the cooling rates with an increasing fraction of helium in the process gas. Consistently, a slight decrease in the melt pool temperatures and dimensions was found.
Functional Muffins Exert Bifidogenic Effects along with Highly Product-Specific Effects on the Human Gut Microbiota Ex Vivo
Authors: Deyaert Stef , Poppe Jonas , Dai Vu Lam , Baudot Aurélien , Bubeck Sarah , Bayne Thomas , Krishnan Kiran , Giusto Morgan , Moltz Samuel , Van den Abbeele Pieter
Published: September 2024

GoodBiome™ Foods are functional foods containing a probiotic (Bacillus subtilis HU58™) and prebiotics (mainly inulin). Their effects on the human gut microbiota were assessed using ex vivo SIFR® technology, which has been validated to provide clinically predictive insights. GoodBiome™ Foods (BBM/LCM/OSM) were subjected to oral, gastric, and small intestinal digestion/absorption, after which their impact on the gut microbiome of four adults was assessed (n = 3). All GoodBiome™ Foods boosted health-related SCFA acetate (+13.1/14.1/13.8 mM for BBM/LCM/OSM), propionate (particularly OSM; +7.4/7.5/8.9 mM for BBM/LCM/OSM) and butyrate (particularly BBM; +2.6/2.1/1.4 mM for BBM/LCM/OSM). This is related to the increase in Bifidobacterium species (B. catenulatum, B. adolescentis, B. pseudocatenulatum), Coprococcus catus and Bacteroidetes members (Bacteroides caccae, Phocaeicola dorei, P. massiliensis), likely mediated via inulin. Further, the potent propionogenic potential of OSM related to increased Bacteroidetes members known to ferment oats (s key ingredient of OSM), while the butyrogenic potential of BBM related to a specific increase in Anaerobutyricum hallii, a butyrate producer specialized in the fermentation of erythritol (key ingredient of BBM). In addition, OSM/BBM suppressed the pathogen Clostridioides difficile, potentially due to inclusion of HU58™ in GoodBiome™ Foods. Finally, all products enhanced a spectrum of metabolites well beyond SCFA, including vitamins (B3/B6), essential amino acids, and health-related metabolites such as indole-3-propionic acid. Overall, the addition of specific ingredients to complex foods was shown to specifically modulate the gut microbiome, potentially contributing to health benefits. Noticeably, our findings contradict a recent in vitro study, underscoring the critical role of employing a physiologically relevant digestion/absorption procedure for a more accurate evaluation of the microbiome-modulating potential of complex foods.
Contact Hole Shrinkage: Simulation Study of Resist Flow Process and Its Application to Block Copolymers
Authors: Kim Sang-Kon
Published: September 2024

For vertical interconnect access (VIA) in three-dimensional (3D) structure chips, including those with high bandwidth memory (HBM), shrinking contact holes (C/Hs) using the resist flow process (RFP) represents the most promising technology for low-k1 (where CD=k1λ/NA,CD is the critical dimension, λ is wavelength, and NA is the numerical aperture). This method offers a way to reduce dimensions without additional complex process steps and is independent of optical technologies. However, most empirical models are heuristic methods and use linear regression to predict the critical dimension of the reflowed structure but do not account for intermediate shapes. In this research, the resist flow process (RFP) was modeled using the evolution method, the finite-element method, machine learning, and deep learning under various reflow conditions to imitate experimental results. Deep learning and machine learning have proven to be useful for physical optimization problems without analytical solutions, particularly for regression and classification tasks. In this application, the self-assembly of cylinder-forming block copolymers (BCPs), confined in prepatterns of the resist reflow process (RFP) to produce small contact hole (C/H) dimensions, was described using the self-consistent field theory (SCFT). This research paves the way for the shrink modeling of the enhanced resist reflow process (RFP) for random contact holes (C/Hs) and the production of smaller contact holes.
Application of Metal Halide Perovskite in Internet of Things
Authors: Chai Zhihao , Lin Hui , Bai Hang , Huang Yixiang , Guan Zhen , Liu Fangze , Wei Jing
Published: September 2024

The Internet of Things (IoT) technology connects the real and network worlds by integrating sensors and internet technology, which has greatly changed people’s lifestyles, showing its broad application prospects. However, traditional materials for the sensors and power components used in the IoT limit its development for high-precision detection, long-term endurance, and multi-scenario applications. Metal halide perovskite, with unique advantages such as excellent photoelectric properties, an adjustable bandgap, flexibility, and a mild process, exhibits enormous potential to meet the requirements for IoT development. This paper provides a comprehensive review of metal halide perovskite’s application in sensors and energy supply modules within IoT systems. Advances in perovskite-based sensors, such as for gas, humidity, photoelectric, and optical sensors, are discussed. The application of indoor photovoltaics based on perovskite in IoT systems is also discussed. Lastly, the application prospects and challenges of perovskite-based devices in the IoT are summarized.
Research on the Magnetorheological Finishing Technology of a High-Steepness Optical Element Based on the Virtual-Axis and Spiral Scanning Path
Authors: Chen Chihao , Guan Chaoliang , Liu Meng , Dai Yifan , Hu Hao
Published: September 2024

Magnetorheological finishing (MRF) of aspherical optical elements usually requires the coordination between the translational axes and the oscillating axes of the machine tool to realize the processing. For aspheric optical elements whose steepness exceeds the machining stroke of the equipment, there is still no better method to achieve high-precision and high-efficiency error convergence. To solve this problem, an MRF method combining virtual-axis technology and a spiral scanning path is proposed in this paper. Firstly, the distribution law of the magnetic induction intensity inside the polishing wheel is analyzed by simulation, the stability of the removal efficiency of the removal function within the ±7∘ angle of the normal angle of the polishing wheel is determined, and MRF is expanded from traditional single-point processing to circular arc segment processing. Secondly, the spiral scanning path is proposed for aspherical rotational symmetric optical elements, which can reduce the requirements of the number of machine tool axes and the dynamic performance of machine tools. Finally, an aspherical fused silica optical element with a curvature radius of 400 mm, K value of −1, and aperture of 100 mm is processed. The PV value of this optical element converges from 189.2 nm to 24.85 nm, and the RMS value converges from 24.85 nm to 5.74 nm. The experimental results show that the proposed combined process has the ability to modify curved optical elements and can be applied to ultra-precision machining of high-steepness optical elements.
Laser Direct Writing of Setaria Virids-Inspired Hierarchical Surface with TiO2 Coating for Anti-Sticking of Soft Tissue
Authors: Zhang Qingxu , Yang Yanyan , Huo Shijie , Duan Shucheng , Han Tianao , Liu Guang , Zhang Kaiteng , Chen Dengke , Yang Guang , Chen Huawei
Published: September 2024

In minimally invasive surgery, the tendency for human tissue to adhere to the electrosurgical scalpel can complicate procedures and elevate the risk of medical accidents. Consequently, the development of an electrosurgical scalpel with an anti-sticking coating is critically important. Drawing inspiration from nature, we identified that the leaves of Setaria Virids exhibit exceptional non-stick properties. Utilizing this natural surface texture as a model, we designed and fabricated a specialized anti-sticking surface for electrosurgical scalpels. Employing nanosecond laser direct writing ablation technology, we created a micro-nano textured surface on the high-frequency electrosurgical scalpel that mimics the structure found on Setaria Virids leaves. Subsequently, a TiO2 coating was deposited onto the ablated scalpel surface via magnetron sputtering, followed by plasma-induced hydrophobic modification and treatment with octadecyltrichlorosilane (OTS) to enhance the surface’s affinity for silicone oil, thereby constructing a self-lubricating and anti-sticking surface. The spreading behavior of deionized water, absolute ethanol, and dimethyl silicone oil on this textured surface is investigated to confirm the effectiveness of the self-lubrication mechanism. Furthermore, the sticking force and quality are compared between the anti-sticking electrosurgical scalpel and a standard high-frequency electrosurgical scalpel to demonstrate the efficacy of the nanosecond laser-ablated micro-nano texture in preventing sticking. The findings indicate that the self-lubricating anti-sticking surface fabricated using this texture exhibits superior anti-sticking properties.
Optimization of Non-Alloyed Backside Ohmic Contacts to N-Face GaN for Fully Vertical GaN-on-Silicon-Based Power Devices
Authors: Hamdaoui Youssef , Vandenbroucke Sofie S. T. , Michler Sondre , Ziouche Katir , Minjauw Matthias M. , Detavernier Christophe , Medjdoub Farid
Published: September 2024

In the framework of fully vertical GaN-on-Silicon device technology development, we report on the optimization of non-alloyed ohmic contacts on the N-polar n+-doped GaN face backside layer. This evaluation is made possible by using patterned TLMs (Transmission Line Model) through direct laser writing lithography after locally removing the substrate and buffer layers in order to access the n+-doped backside layer. As deposited non-alloyed metal stack on top of N-polar orientation GaN layer after buffer layers removal results in poor ohmic contact quality. To significantly reduce the related specific contact resistance, an HCl treatment is applied prior to metallization under various time and temperature conditions. A 3 min HCl treatment at 70 °C is found to be the optimum condition to achieve thermally stable high ohmic contact quality. To further understand the impact of the wet treatment, SEM (Scanning Electron Microscopy) and XPS (X-ray Photoelectron Spectroscopy) analyses were performed. XPS revealed a decrease in Ga-O concentration after applying the treatment, reflecting the higher oxidation susceptibility of the N-polar face compared to the Ga-polar face, which was used as a reference. SEM images of the treated samples show the formation of pyramids on the N-face after HCl treatment, suggesting specific wet etching planes of the GaN crystal from the N-face. The size of the pyramids is time-dependent; thus, increasing the treatment duration results in larger pyramids, which explains the degradation of ohmic contact quality after prolonged high-temperature HCl treatment.
A Ligand-Free Approach towards Coumarin Analogs via Natural Deep Eutectic Solvent-Mediated Suzuki–Miyaura Coupling
Authors: Katopodi Annita , Nikolaou Nikolaos , Kakokefalou Vasiliki , Alexandratou Eleni , Matzapetakis Manolis , Zervou Maria , Detsi Anastasia
Published: September 2024

A ligand-free approach for the Suzuki-Miyaura cross coupling reaction using Natural Deep Eutectic Solvents (NaDES) towards coumarin analogs is described. A model reaction between the synthetically prepared 3-(4-acetyloxy-phenyl)-6-bromo-4-methyl-coumarin (3b) and phenylboronic acid was performed in five different NaDES as well as in pure glycerol, using two inorganic bases and palladium catalysts. The reaction proceeded smoothly in Choline Chloride/Glycerol (ChCl/Gly) and Betaine/Glycerol (Bet/Gly) NaDES at 90 °C in 24 h, affording the desired product in high yields up to 95%. The combination of K2CO3, Pd(OAc)2 and ChCl/Gly NaDES provided optimum yields and high purity of the desired compounds, while the solvent was successfully recycled and reused up to two times. The developed methodology is applicable to boronic acids bearing various substituents. The formation of palladium nanoparticles in the reaction mixture was observed, and the size of the nanoparticles was associated with the reaction yield. In addition, in all the glycerol-based NaDES, an effective removal of the acetyl group of the acetyloxy–coumarin analogs was observed; thus, it is noteworthy that the Suzuki–Miyaura coupling and the deacetylation reaction were achieved in one pot. The ten novel coumarin derivatives synthesized were structurally characterized using 1D and 2D NMR spectroscopy and were tested for their cytotoxicity against the A431 squamous cancer cell line, presenting significant activity.