bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct Torque Control of an Induction Motor Using Fractional-Order Sliding Mode Control Technique for Quick Response and Reduced Torque Ripple
Authors: Gudey Satish Kumar , Malla Mohan , Jasthi Kiran , Gampa Srinivasa Rao
Published: May 2023

The performance of electric drive propulsion systems is often degraded by the high torque and flux ripples of an electric drive. Traditional control methods, such as proportional plus integral (PI) controllers and classical sliding mode controllers (SMCs), have shown good response and reduced torque ripple, but even lower ripple content at low voltage levels is required for its effective use in electric vehicle (EV) applications. In this paper, a new direct torque control (DTC) technique with space vector pulse width modulation (SVPWM) using fractional-order sliding mode control (FOSMC) for a two-level inverter (2LI) at constant switching frequency is proposed. The effectiveness of this proposed controller is compared with a conventional proportional-integral controller and a conventional sliding mode controller (SMC). Simulink models are developed using MATLAB version R2018a to analyze the robustness of the proposed control strategy. Simulation results demonstrate the advantage of the proposed controller in reducing the torque ripples at steady state with less settling time during sudden load change conditions. The proposed control technique also demonstrates better utilization of the stator flux through flux trajectory waveforms.
THE MODERN TECHNOLOGIES USAGE IN THE HEALTH-PRESERVING ACTIVITIES OF EDUCATORS OF PRESCHOOL EDUCATION INSTITUTIONS
Authors: VASHAK O. , VILHOVA O.
Published: May 2023

Modern reforms taking place in education require new approaches to the organization of educational space in preschool institutions. Currently, much attention is paid to the system of improving teachers; healthcare work. Education of preschool children in a responsible attitude to their health, as the most important human value, should be carried out in the course of health-saving activities of educators. The implementation of these tasks involves the introduction of modern health technologies into the system of work on preserving and strengthening the health of preschool children. The main principle of these technologies is the prevention of diseases, which is extremely crucial for a childs body, which develops quite quickly. In our opinion, health technologies will contribute to the formation of preschoolers; ideas about health, a valuable attitude to the environment, and motivation for a healthy lifestyle. The diversity of health technologies will allow teachers to further improve health-preserving activities in preschool education institutions.
IMPLEMENTATION OF MODERN DIGITAL EDUCATIONAL TECHNOLOGIES IN THE TRAINING OF MATHEMATICS TEACHERS
Authors: MOSKALENKO O.
Published: May 2023

The article examines the latest modern learning technologies for the training of mathematics teachers in the conditions of digitalization of education. Emphasis is placed on models of the latest didactic technologies in combination with digital ones during the training of mathematics teachers in institutions of higher education: instructional distance learning, resource-oriented learning, innovative project-based learning using digital tools, online learning in collaboration, learning with the help of online - trainings, knowledge control using a digital portfolio.
CONSTITUTIONAL RESEARCH OF THE AXIOLOGICAL BASIS OF THE TRAINING OF MASTERS OF HUMANITIES IN UNIVERSITIES
Authors: VINNYCHUK R.
Published: May 2023

In the article, taking into account the results of the methodological and theoretical substantiation of the scientific foundations of professional training, a systematic analysis of the data of the ascertainment experimental work on the study of the axiological foundations of the educational process was carried out in order to develop the target and technological blocks of the context-professional model of the training of future masters (culturalists, historians, religious studies, philologists, philosophers).The tasks of ascertaining research include: 1) to find out how the respondents understand the essence of the master's training system on axiological grounds; 2) identify and systematize the leading groups of values and value attitudes, according to the master's students; 3) to determine possible options for prospective improvement of the content, technologies and methods of training specialists on axiological grounds.Methods of ascertaining research: questionnaire (frequency analysis of answers); ESE content analysis; expert assessments; computer quantification; observation; quantitative and qualitative display of data; ranking; stepwise statistical processing.On the basis of theoretical research, experimental examination and generalization of materials, the development of the axiological foundations of the context-professional model of training future masters in the humanitarian field is determined in the perspective of the research; it was analyzed that the educational training environment should be based on the principles of axiology and open learning: reliance on information technologies; design of modern content of education; development of innovative methods of formation and development of the valuable component of professional competences; solving the problems of measuring the quality of education; changes in the traditional role of the teacher as a translator of knowledge and mastering the role of a mentor, senior colleague, consultant, scientific supervisor.
FORMS OF ORGANIZATION OF THE PRE-PROFESSIONAL CHOREOGRAPHIC TRAINING IN UKRAINE IN THE 20S OF THE XX CENTURY
Authors: BLAHOVA T.
Published: May 2023

The article reveals the peculiarities of the development of choreographic education in Ukraine in pre-professional forms of organization in the 20s of the XX century. In the aspect of socio-political and cultural determinants, the organizational and pedagogical foundations of choreographic training of the younger generation in the structure of general and out-of-school education are analyzed. The educational value of the phenomenon of pre-professional dance creativity is clarified. It has been observed that during the study period children's dance amateurism was formed in the educational, cultural and artistic spheres in institutions of various functional purposes: in general education institutions, dance vocational schools, art studios, children's and youth clubs. The dissemination of elementary choreographic knowledge also took place in various mass forms of aesthetic and educational leisure: concerts, literary and musical matinees, evenings, and mass folk festivals.Based on the analysis of the educational sector's reporting documentation of the time, it was found that official support for school and out-of-school amateur children's choreography was centralized, regulated by norms and methods, and subordinated to the ideological narratives of the society of the time. Physical education bias dominated the arrangement of the content of school motor training. The priority direction of leisure time choreographic activities of schoolchildren in institutions of mass culture is the attraction to newly created mass dance forms of Soviet origin, lexically simple and accessible for assimilation. The main principles of mass children's choreographic performance were the availability of dance vocabulary, a combination of elementary natural movements, jumps, running, simplicity and artistry of musical accompaniment.It is proved that in the period under study, the formation of the content of pre-professional choreographic training of children and students involved the correlation of ideological and educational tasks. Mass choreographic forms were interpreted primarily as an effective component of the overall system of class education. At the same time, it was noted that the quality level of children's amateur choreography in the system of cultural and mass work remained generally low, despite its popularity in society. The need to improve pre-professional dance creativity in various forms of organization remained relevant.
O. K. NATALEVYCH TEACHING SCHOOL IN MEMORIES OF ITS STUDENTS AND ARCHIVE MATTERS
Authors: TSEBRIY I. , GOLOVASHYCH E.
Published: May 2023

The materials of the article introduce a prominent personality in the art pedagogy of Poltava Oblast in the middle of the 20th century – Olena Kostyantynivna Natalevich, whose teaching school was known far beyond the borders of Ukraine. The authors of the article set themselves the goal of recreating the portrait of O.K. Natalevich – a teacher, mentor, musician, concertmaster – based on the memories of her students and archival files, to show the heredity of the generations of Olena Kostyantynivna's school in Ukraine and on European grounds, to emphasize her moral and human qualities, the cohesion of her class of students, their love for their the teacher The materials of the article include archival files of the Poltava College of Arts, as well as materials of two International Art Readings dedicated to the memory of O.K. Natalevich, to her 95th and 100th anniversaries. We can talk a lot about her pedagogical methods, but our task was to recreate the portrait of an outstanding personality, a teacher and educator, a musician, just a highly moral person. In the musical circles of Ukraine and beyond, the memory of O.K. Natalevich, musicians consult with her pedagogical principles, with her internal moral, aesthetic and musical orientations.
EDUCATIONAL AND EDUCATIONAL ACTIVITIES OF PUBLIC LIBRARIES IN INDEPENDENT UKRAINE (1990-yy.)
Authors: POLYAKOVA-LAGODA M.
Published: May 2023

At the end of the article, a retrospective analysis of the educational and educational activities of public libraries of Ukraine in the 1990s of the 20th century was carried out against the background of problems and values, development and priorities of the society at that time. Changes in library legislation, types and types of libraries, content and structure of their activities, processes of creation of a number of national libraries, development in the last decade of the 20th century were studied. modern library system of Ukraine, initiation of active formation of electronic libraries and resources. As part of the contemporary reform of the country's socio-political life, the peculiarities of stimulating readers' interest in national culture and socio-political life, the initiation of publication of textbooks and study guides on librarianship, the integration of traditional library technologies with the creation of new information models of social development, the use of Internet technologies in librarianship. An analysis of the main directions of research into the history of librarianship and libraries in the context of the socio-cultural development of Ukraine in the 20th century was carried out, including the study of the history of public libraries of various cultural centers, societies, and educational institutions. Among the forms of organization of educational and educational activities of public libraries at the turn of the 2000y., the following are highlighted: art exhibitions, literary salons, book presentations, readers' conferences. The methods of educational and educational activities of public libraries in the 1990s include: library debates, use of library posters, reading aloud, literary quizzes, role-playing and intellectual games, trials with elements of theatralization of literary works, book discussions, family reading, etc. It is proved that in the development of educational and educational activities of public libraries of Ukraine at the end of the 20th century, the main characteristics were, on the one hand, a fundamental transformational restructuring of library work based on the revival of national ideas of enlightenment and education in independent Ukraine, and, on the other hand, stagnation of library work in this historical a period caused by the economic crisis in the country, rising prices and inflation.
Tourists’ Engagement on Tourism Organizations' Facebook Pages: The Role of User-Generated Content
Authors: Santos Sara
Published: May 2023

Tourism industry prospects are presented by digital marketing and consumer travel behaviour changes. Given this fact, digital content marketing (DCM) assumes greater significance for enhancing social media user engagement. Providing valuable and relevant information that differentiates the company and catches the consumers' attention has been one of the current challenges in this area. The wide availability of information on the Internet changes how consumers engage with it. Therefore, creating and disseminating educational and pertinent content is now mandatory. To ensure the effectiveness of the process, it is crucial to understand with whom, how, when, and where communication will be carried out. Thus, tourism organisations must offer targeted, tailored, and appealing information to interest customers more about the destinations. Social media is a commonly used strategy for tourism promotion initiatives, where User Generated Content (UGC) has emerged as one of the most popular means to achieve this goal. “Turismo Centro de Portugal” is responsible for publicizing the Centre region of Portugal, including cities such as Coimbra, Aveiro, Viseu, and Leiria. Turismo Centro de Portugal has won several communication-related awards, having already been recognized internationally for its advertising campaigns. Numerous studies analyzing user-generated content and digital content are available, but they invariably look at businesses rather than tourism-related institutions. Hence, conducting a study to identify follower engagement and involvement in digital content marketing posts versus user-generated content posts applied to the Turismo Centro de Portugal was considered pertinent. For this purpose, a qualitative analysis of the existing content and its results on Turismo Centro de Portugal's Facebook page was developed based on a social media content analysis framework adapted from other authors. The results revealed the importance of using user-generated content in a social media communication strategy for tourism organisations.
Circular Economy in Tourism: A System-Level Approach
Authors: Renfors Sanna-Mari
Published: May 2023

Tourism is a sector where circular economy unfolds extensive opportunities. Despite being classified as a service sector, tourism depends on significant quantities and flows of exhaustible natural resources. As a result, circular economy in tourism has become an emerging field of study. This can also be ascribed to the fact that the topic of circular economy is currently high on the political agenda, especially in Europe. Because circular economy is receiving exponential attention from policy makers, it has also received more interest among tourism scholars.

The aim of this paper is to increase understanding of circular economy in tourism research considering its systemic nature. The paper is based on a review of the scientific articles published in the years 2015-2022. The research question is: What are the recent developments and trends in the research on CE in tourism from a system-level approach?

The findings indicate that the previous studies have mainly focused on the micro level from the environmental and business management perspectives in the hospitality sector. However, there are many emerging research themes, for example circular consumption behaviour, circular economy and smart tourism. In addition, other types of tourism companies should be considered, e.g., spas, events, and programme service providers.  It is evident that more research is required on the meso and macro levels. In all levels, more attention should be paid on the social and cultural aspects of circular economy in tourism.
Experience in Using Combined Oral Contraceptives for Internal Genital Endometriosis
Authors: Гутикова Л.В.
Published: May 2023

В течение 1,5 года обследовано 60 женщин репродуктивного возраста с аденомиозом на фоне лечения комбинированным оральным контрацептивом, содержащим 30 мкг этинилэстрадиола и 2 мг диеногеста, в пролонгированном режиме. Оценка результатов цветового доплеровского картирования (ЦДК) миометрия выявила исходное усиление кровотока в зонах расположения гетеротопий в миометрии. Эффективность лечения подтверждается уменьшением количества локусов кровотока в миометрии на 45% и более. Сохраняющийся повышенный уровень васкуляризации миометрия у 10% женщин по данным ЦДК может использоваться как предиктор неэффективности длительной стероидной терапии у пациенток с аденомиозом.

There were examined 60 women of reproductive age with adenomyosis for 1.5 years during treatment with a combined oral contraceptive containing 30 μg of ethinyl estradiol and 2 mg of dienogest in a prolonged regimen. Evaluation of the results of color Doppler mapping (CDC) of the myometrium revealed an initial increase in blood flow in the areas of heterotopias in the myometrium. The effectiveness of the treatment is confirmed by a decrease in the number of blood flow loci in the myometrium by 45% or more. The persistent elevated level of myometrial vascularization in 10% of women according to the CDC can be used as a predictor of the failure of long-term steroid therapy in patients with adenomyosis.
Prognostic Value of Determining Neuropeptides and Apoptotic Factors in Newborns with Seizures
Authors: Гурбанова Г.М. , Мамедбейли А.К. , Рагимова Н.Д.
Published: May 2023

Цель исследования. Изучение содержания нейронспецифической энолазы (NSE), белка S-100, активированной молекулы лейкоцитарной клеточной адгезии (ALCAM), «рецептора смерти» Death Receptor (DR5) в сыворотке крови у новорожденных детей с неонатальными судорогами. Материалы и методы. Проведено проспективное исследование 110 новорожденных с судорогами со сроком гестации от 38 до 42 недель. Результаты. В ходе проведенных исследований установлено, что уровень NSE у новорожденных с судорогами достоверно превышал концентрацию нейропептидов новорожденных контрольной группы в 3,1 раза; S-100 в 3,3 раза; ALCAM в 2,5, DR-5 в 2,1 раза по сравнению со здоровыми новорожденными. При проведении корреляционного анализа выявлены множественные связи с анамнестическими, клиническими, иммунохимическими показателями новорожденных с судорогами. Выводы. Экспрессия нейропептидов и факторов апоптоза у новорожденных на фоне гипоксически-ишемической энцефалопатии с нарушением проницаемости гематоэнцефалического барьера приводит к поддержанию судорожной активности и усугубляет дальнейший неблагоприятный неврологический исход.

The purpose of the research. To study the content of neurospecific enolase (NSE), S-100 protein, activated leukocyte cell adhesion molecule (ALCAM), and Death Receptor (DR5) in the blood serum of newborns with neonatal seizures. Materials and methods. There was carried out a prospective study of 110 newborns with seizures with age stational age of 38 to 42 weeks. Results. As a result of the studies, there was found that the level of NSE in newborns with seizures reliably exceeded the concentration of neuropeptides in newborns of the Control Group by 3.1 times; S-100 by 3.3 times; ALCAM by 2.5; and DR-5 by 2.1 times compared with healthy newborns. Correlation analysis revealed multiple links with anamnestic, clinical, and immunochemical parameters of newborns with seizures. Conclusions. The expression of neuropeptides and apoptosis factors in newborns on the background of hypoxicischemic encephalopathy with a violation of the permeability of the blood-brain barrier leads to the maintenance of seizure activity and exacerbates further unfavorable neurological outcome.
Implementasi Media PowerPoint dalam Mengembangakan Kemampuan Mengenal Angka dan Huruf
Authors: Fitri Zayyana Zahrotul
Published: May 2023

Media powerpoint biasanya hanya digunakan siswa sekolah menengah ke atas, mahasiswa, pekerja kantoran dan lainnya. Padahal, semakin berkembangnya teknologi mengharuskan para pendidik khususnya guru PAUD untuk lebih siap dan terampil dalam menggunakan teknologi sebagai media pembelajaran. Hal tersebut dapat meningkatkan kompetensi guru PAUD maupun kualitas lembaga sekolahnya. Tujuan penelitian ini adalah untuk mengetahui penerapan media powerpoint dalam mengembangakan kemampuan mengenal angka dan huruf. Jenis penelitian ini adalah penelitian kualitatif menggunakan metode deskriptif. Teknik pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Observasi dilaksanakan diÂ  RA Perwanida Ketintang Surabaya kelompok A1 dan wawancara kepada kepala sekolah dan guru kelas A1. Teknik analisis data menggunakan reduksi data, penyajian data, dan menarik kesimpulan. Analisis hasil penelitian menunjukkan 1) Implementasi media powerpoint di RA Perwanida saat pembelajaran zoom class tidak monoton dan siswa ikut terlibat aktif karena terdapat tampilan teks dan gambar; 2) Hasil uji coba penerapan media powerpoint untuk mengenalkan angka dan huruf pada anak menunjukkan bahwa siswa kelompok A1 dapat berkembang sesuai harapan (BSH) dengan mampu menyebut, menunjuk, membilang, menghitung dan menulis angka maupun huruf. Temuan penelitian ini memberikan kontribusi berupa pemahaman dan masukan pada guru PAUD atau pengajar lainnya bahwa media powerpoint juga dapat digunakan sebagai media pembelajaran yang efektif.
Komunikasi dalam Pembelajaran Anak Usia Dini di RA Salsabila Kabupaten Ciamis
Authors: Nurannisa Nina , Iyan Royani  , Ulfah Aisyah
Published: May 2023

Penelitian ini bertujuan untuk mendapatkan informasi mengenai pelaksanaan komunikasi dalam pembelajaran, pola komunikasi yang digunakan pendidik, dan permasalahan komunikasi suportif dan komunikasi defensif yang terjadi di RA Salsabilla. Metode yang digunakan dalam penelitian yaitu penelian kualitatif dengan teknik observasi dan wawancara. Hasil Penelitian menunjukan kegiatan pembelajaran yang dilaksanakan oleh pendidik di RA Salsabila cenderung menggunakan komunikasi verbal secara lisan. Sedangkan komunikasi non-verbal digunakan pada kondisi-kondisi tertentu yang disampaikan tanpa menggunakan kata-kata. Kedua bentuk komunikasi tersebut sangat mendukung dalam kegiatan pembelajaran/menyampaikan pesan. Pola komunikasi yang digunakan oleh pendidik di RA Salsabila adalah pola komunikasi satu arah, pola komunikasi dua arah, dan pola komunikasi multi arah. Adapun permasalahan komunikasi suportif dan defensif yang terjadi di RA Salsabila, yaitu anak bersikap defensif kepada teman seperti mengejek atau menghina, adanya permasalahan antara pendidik dan anak, terdapat juga anak yang defensif mudah tersinggung, dan ada anak yang berkata kasar ketika berkelahi dengan anak lainnya. Ada beberapa pendekatan yang pendidik lakukan untuk mengatasi permasalahan komunikasi yaitu melalui pendekatan secara personal dengan menasihati, memberikan pemahaman, dan contoh.
Algorithm of customs risk forecasting in export supply chains
Authors: Ermakova E. V.
Published: May 2023

Aim. To develop recommendations on forecasting customs risks in export supply chains (ESC) for participants in foreign economic activity (FEA).

Tasks. To consider the specific and problematic aspects of the customs risks from the standpoint of participants of foreign economic activity; to offer the variant of customs risks classification; to highlight possible risk-forming factors; to form the algorithm of forecasting.

Methods. The author used general scientific methods (analysis, synthesis, decomposition) and special scientific methods (method of expert evaluations, legal analysis).

Results. Recommendations for participants of foreign economic activity on predicting customs risks in EDS were developed and presented in the form of an algorithm. Option of visualizing the results of the forecast in the form of a forecast map is offered.

Conclusions. Prediction algorithm aimed at improving the efficiency of customs risk manage­ment in EDS has been presented. Application of the above algorithm will reduce the unreason­able logistical costs of exporters, which in general will contribute to improving the competitive­ness of EDS and the development of export activities.
Glycerol-mediated lysosomal associated proteins as a novel anticancer theory in colon cancer cell line
Authors: Ismail Alaa , Salah Ahmed , Guirgis Adel , Muawia Shaden , Khalil Hany
Published: May 2023

Background: Colon cancer begins in the large intestine (colon) and is aggressive due to late diagnosis, so there is a poor prognosis and higher mortality rates, as reported. Colon cancer has become a vital research area requiring more investigation of cellular signaling in its initiation and development. Aim: The study aimed to investigate the biological effects of Glycerol in cell proliferation and the possible regulation of cellular signaling by exogenous treatment of Glycerol in colon cancer cells compared with colon mucosal epithelial cells. 

Materials and Methods: The influence of Glycerol on cell viability rate was monitored by inverted microscopy, and the number of living cells was assessed upon incubation with different concentrations of Glycerol. We further inspected the apoptotic rate of CaCo-2 cells by using Annexin-V staining by flow cytometry. Moreover, we achieved the expression profile of lysosomal-associated proteins, LAMP-1 and LAMP-2, in treated cells using qRT-PCR and flow cytometry. Finally, we monitored the released pro-inflammatory cytokines and anti-inflammatory in response to Glycerol treatment using ELISA assay. 

Results: Our results showed that Glycerol treatment could prevent cancer cell proliferation without any detectable cytotoxic occurrence in the normal cells. Interestingly, we evidenced that Glycerol targets and breaks down the lysosomal activities by inhibiting the expression profile of both LAMP-1 and LAMP-2. Furthermore, Glycerol treatment successfully adjusted the production of IL-6 and IL-8 as pro-inflammatory cytokines while stimulating the production of anti-inflammatory cytokines, IL-4 and IL-10, in a time-dependent manner. 

Conclusion: These data provide evidence for the anti-cancer properties of Glycerol in colon cancer cells via targeting lysosomal activities and disturbance of the degradation events in colon cancer cells.
OPEN FRACTURE MANAGEMENT: UPDATE ON INITIAL EVALUATION AND CLASSIFICATION
Authors: Marcela Barros Ramirez Claudia
Published: May 2023

This article reviews the management of open fractures, which occur when there is a break in the skin exposing the underlying bone and soft tissues, leading to signicant morbidity and mortality. The article focuses on the initial evaluation, classication, and treatment of these fractures. The Gustilo-Anderson classication system, which is based on the degree of soft tissue injury, is the most widely used classication system for open fractures. However, the Tscherne classication system, which focuses on the severity of soft tissue injury and the degree of fracture displacement, has been shown to be a more reliable predictor of infection and nonunion in some studies. The article also covers the AO/OTA classication system, a newer classication system that integrates important aspects of the Gustilo-Anderson classication system to provide more comprehensive guidance for the treatment of open fractures. Treatment of open fractures is complex and requires a multidisciplinary approach guided by the severity of the injury. Early antibiotics, early surgical debridement, and wound irrigation have been shown to reduce the risk of infection and improve outcomes. Patients with open fractures were more likely to have associated injuries, longer hospital stays, and higher hospital costs compared to patients with closed fractures
A STUDY OF HISTOMORPHOLOGICAL SPECTRUM OF HYPERPIGMENTED SKIN LESIONS IN ADULTS
Authors: V. Agale Shubhangi , Narute Swati , Dhakhre Akshata , Gore Indira , N. Hiwale Buddheshwar
Published: May 2023

Background: Hyperpigmentary skin disorders may be dened as increased pigmentation of the skin and/or mucus membranes. Pigmented skin lesions comprise a large component of most histopathologists' workload, and although there is a wide spectrum of histological appearances most can be reported as simple benign naevi. Pathologic examination often serves as a complementary or a conrmative part of the diagnosis. The histologybased treatment principles may be helpful for establishing a standardized treatment algorithm for hyperpigmented skin lesions. A prospective study was conducted to assess histomorphological features of hyperpi Methods: gmented skin lesions. The study included 60 patients for a duration of 2 years. Clinical history like age, sex, site, duration of the lesion, size of the lesion, signicant medical history, and clinical diagnosis were noted. Out of 60 cases, major Result: ity (40 %) were classical lichen planus and its variants. Most of cases were in the age group of 21–30 years and showed male preponderance with both upper and lower limbs as the most common site of distribution. In present study, Conclusion: hyperpigmented skin lesions were most common in males with lichen planus as the most common histopathological diagnosis. The histopathologic examination serves as a complementary or a conrmative part of diagnosis, which helps in management of these patients.
THYROID HORMONE LEVELS AND ITS RELATION TO OUTCOMES IN ICU PATIENTS
Authors: Krishna Swathi Pavuluri , N Senthil. , L Suja. , Anil Archa
Published: May 2023

Background: Free thyroid hormone levels were analyzed in critically ill patients, admitted to the ICU who were more than 18 years of age without any underlying thyroid illness. APACHE 2, FT3, FT4, and TSH levels were analyzed and compared using ROC curves. Aim of the study: To assess whether free thyroid hormone levels were better predictors of outcomes compared to existing tools. Study design: This is a prospective observational study undertaken in the Department of General medicine at Sri Ramachandra institute of higher education and research, Chennai, Tamilnadu has done between 2019 to 2021 with the approval from the ethics committee. A total of 70 critically ill patients were admitted to the ICU, who were more than 18 years of age without any underlying thyroidal illness. Patients with known thyroid disease, pregnancy, and drugs causing alteration of thyroid hormone levels were excluded from the study. Blood samples were collected immediately after admission and APACHE 2 scores were calculated within 24 hours of admission. Parameters were analyzed using various statistical methods. Results: A total of 70 patients were included in the study, of which 63 were survivors and 7 patients expired. Most of the study population were males (45) and the mean age of the survivors 49.71 ± 10.72 was and for nonsurvivors was 54.29 ± 15.07. Using the Pearson correlation in APACHE 2 and FT3, APACHE 2 and FT4 showed a statistically signicant correlation in survivors (P 0.02; P 0.05), while in non-survivors only APACHE 2 and FT3 showed a signicant correlation ( P 0.008). Using ROC curves, APACHE 2 alone showed signicant predictive validity in predicting mortality in critically ill patients in our study ( AUC 0.985; P <0.001). Conclusion: In our study combined APACHE 2 and FT3 showed a signicant correlation in both survivors and non-survivors as well. APACHE 2 has better predictive value compared to other parameters and FT3 alone did not have predictive validity. So large sample is required to test the value of free thyroid hormones in predicting outcomes in critically ill patients.
DETERMINATION OF SENSITIVITY TO LINEZOLID IN DRUG-RESISTANT TUBERCULOSIS CASES
Authors: Preeti Preeti , Joshi Ameeta , Dev Madhuparna
Published: May 2023

Introduction: Tuberculosis is caused by Mycobacterium tuberculosis and remains a leading infectious cause of mortality globally. Linezolid, an oxazolidinone, has strong in vitro evidence of action against drug resistant isolates of M. tuberculosis. It can be administered orally or intravenously and has been shown to be highly benecial if used for at least six months. Aim: To determine the sensitivity of linezolid in patients with Drug-resistant tuberculosis. Methods: An 18-month observational study was conducted in the TB Culture and Drug Sensitivity Screening lab of the Department of Microbiology at the Tertiary Care Center in Mumbai on a sample size of 1031 patients. Samples from pulmonary and extrapulmonary tuberculosis patients of MDR/XDR (conrmed by LPA) cases were collected for phenotypic DST for Linezolid utilizing the automated BACTEC MGIT 960 system in a biosafety level 3 lab. Results: Out of 1031 patients, 88.9% were sensitive to Linezolid, and 11.1% were resistant. Linezolid sensitivity for MDR-TB patients was 88.72% of the cases being sensitive, and 11.28% resistant. Linezolid sensitivity in pre-extensively drug-resistant tuberculosis was 88.27% and 11.73% were resistant. Among 1031 samples, 50 samples taken for Linezolid and Bedaquiline liquid DST, of which 15 were XDR and 4 samples among these 15 XDR samples were sensitive to Linezolid Conclusion: The study concluded that Linezolid is an effective drug used in the NTEP for the treatment of M/XDR-TB, H mono/poly DRTB, as well as the newer BPaL regimen. The results showed an overall sensitivity of 88.9%.
FROM BENCH TO BEDSIDE: GENE EXPRESSION ANALYSIS OF THE INVASIVE FRONT IN ORAL CANCER – A SYSTEMATIC REVIEW
Authors: Pal Singh Chawla Jatinder , Kaur Madan Gundeep
Published: May 2023

This review study aims to provide an overview of the current knowledge of gene expression patterns in the invasive front of oral cancer. The invasive front is a critical region in cancer progression, where the tumor cells interact with the surrounding tissue and inuence tumor growth, invasion, and metastasis. In recent years, several studies have investigated the gene expression changes that occur in the invasive front of oral cancer, revealing the involvement of various molecular pathways and signaling networks. The review summarizes the ndings of these studies, highlighting the genes and pathways that are upregulated or downregulated in the invasive front of oral cancer. Moreover, the study discusses the potential diagnostic and therapeutic implications of these ndings, emphasizing the need for further research to improve our understanding of oral cancer pathogenesis and to develop more effective treatments. Overall, this review provides insights into the molecular mechanisms underlying the invasive behavior of oral cancer and suggests new avenues for future research in this eld.
Re-Emergence of Monkeypox Amidst COVID-19 Pandemic in Africa: What is the Fate of the African Healthcare System?
Authors: Sokunbi T.O. , Omojuyigbe J.O. , Mowobi O.D.
Published: May 2023

The continuous rise in the number of monkeypox cases amidst the ongoing COVID–19 pandemic in Africa calls for concern, especially regarding its possible impact on the healthcare system. The current state of the healthcare system contributes substantially to the limitation of COVID–19 elimination in the region, which shows the poor state of the system. The re–emergence of the monkeypox virus amidst the pandemic means that the system must be strengthened to provide quality healthcare delivery for Africans. Therefore, it is high time that African health policymakers and governments begin to make decisions, decisions that will determine the fate of the African healthcare system and, consequently, the lives of people living in Africa in the ongoing event of COVID–19 and monkeypox.
Zelforganisaties bouwen bruggen: De overbruggende functie van Kaapverdische zelforganisaties in Rotterdam
Authors: da Graça António A.
Published: May 2023

Hoe ‘nieuwe burgers’ vanuit hun gedrag en beleving betrokken zijn bij de Nederlandse samenleving en hun etnische gemeenschappen, is een thema dat sinds jaar en dag veel aandacht krijgt van zowel wetenschappers als politici en beleidsmakers (vgl. Schnabel, 2000). Dit verschijnsel staat bekend als ‘sociale cohesie’. Van dit begrip zijn uiteenlopende definities en interpretaties te vinden, want het is een meerduidig en meerdimensionaal concept. Niettemin zijn er enkele kenmerken die steeds terugkeren in verschillende definities. Te denken valt aan contacten tussen de leden van een groep, saamhorigheidsgevoelens, identificatie, participatie in het gemeenschapsleven, onderling vertrouwen, en gedeelde normen en waarden.
Kwetsbaar burgerschap: Naar een vrijplaats voor boeren, burgers en buitenlui
Authors: Postma Dirk Willem
Published: May 2023

Het is woensdag 16 februari 2011, tien uur ‘s ochtends op buurtboerderij Ons Genoegen aan de groene rafelrand van het Amsterdamse Westerpark. Een waterig winterzonnetje doet zijn uiterste best om door de wolken heen te breken. Op het terras wordt een sigaretje gerookt door de schoonmaker en twee medevrijwilligers die vandaag de bar en keuken bestieren. Zij vragen een gast die nogal luidruchtig met zijn zoon speelt om rekening te houden met de workshop Mindfulness die op dat moment op de zolderverdieping van de boerderij plaatsvindt. Aan de rand van het erf legt de tuingroep een composthoop aan en vlechten een hek van wilgentakken die de week daarvoor zijn gesnoeid op de naastgelegen begraafplaats Sint Barbara. Sommige takken zijn al kaalgevreten door de schapen en geiten. Bij vorst krijgen zij deze takken als ruwvoer. Door het weiland tussen de begraafplaats en de boerderij komt Rob aangelopen. De schapen en geiten volgen hem op de voet naar de stal, waar de dieren worden gevoerd. Bij de stal aangekomen, groet hij de twee mannen die zich daar omkleden voor het leegpompen van de greppels in het deels onder water gelopen weiland. Er wordt nog even nagepraat over de geit die de dag daarvoor door de schoonmaker uit een benarde positie was bevrijd; deze hing met een pootje aan de hoge ruif op de kar en kon met zijn andere pootje niet bij de grond. Sindsdien loopt het geitje mank, ze houdt haar rechtervoorpootje omhoog. Dit incident wordt het gesprek van de dag; alle vrijwilligers en bezoekers van de boerderij maken zich zorgen. Ze stellen vragen aan de schoonmaker, die in de noordelijke bergen van Irak tussen de geiten is opgegroeid, en geven – gevraagd en ongevraagd – adviezen aan de weilandwerkers.
Toolkit gezinsbegeleider in de wijk: Eigen regie, teamwork en hulpverlening
Authors: van Rooij Marieke
Published: May 2023

De transitie jeugdzorg moet leiden tot minder bureaucratie en minder versnippering van zorg. Hulp moet meer herkenbaar en dichterbij gezinnen georganiseerd worden. Ook voor hulpverleners heeft dit consequenties: zij worden in wijkteams ‘generalisten’ die op meerdere terreinen kennis en vaardigheden nodig hebben. 'Toolkit gezinsbegeleider in de wijk' biedt hulpverleners een groot aantal praktische, werkzame instrumenten voor het werken met gezinnen ‘aan huis’. Deze zijn verdeeld over acht verschillende domeinen: opvoeden, relaties en vriendschap, lichamelijke gezondheid, emotionele gezondheid, school, werk en vrije tijd, financiën, huisvesting en justitie. De eigen regie van het gezin staat daarbij steeds centraal. Want de meeste voldoening geeft het iemand, als die zijn eigen probleem oplost. Ook is er in het boek ruim aandacht voor de hulpverlener zelf, die vaak op meer afstand van zijn organisatie en collega’s komt te staan. Hoe zorg je goed voor je zelf? Hoe blijf je gezond en geïnspireerd je werk uitvoeren? Ook het aspect ‘samenwerken’ komt uitgebreid aan de orde, waarbij communicatie met de ander de rode draad vormt. Welke communicatievaardigheden komen van pas? Hoe voer je een effectief overleg en een zinvolle casuïstiekbespreking? 'Toolkit gezinsbegeleider in de wijk' beslaat vijftien jaar ervaring in het brede veld van jeugdhulpverlening. Het bevat vele praktijkvoorbeelden van de auteur en collega’s. Met het boek hoopt de auteur studenten en collega’s te inspireren voor het mooie werk met gezinnen, in een tijd van grote verandering. Marieke van Rooij is werkzaam als freelance gezinsbegeleider, werkt als jeugdhulpverlener in een wijkteam van Buurtzorg Jong en is docent op Hogeschool Inholland, afdeling pedagogiek.
A Comparative Study of Post-Operative Outcomes for Off-Pump and On-Pump Coronary Artery Bypass Grafting
Authors: Uddin Md Jilhaj , Ahsan Kamrul , Ali Md Ayub , Md Kamruzzaman Md Kamruzzaman , Mahato Gajendra Nath
Published: May 2023

Introduction: Coronary artery bypass grafting (CABG) is a common surgical procedure for the management of coronary artery disease. Off-pump (OPCAB) and on-pump (ONCAB) CABG have been compared in various studies, but limited data exists for the Bangladeshi population. The present study was conducted to shed further light on the topic relative to the Bangladeshi demographic. Methods: This retrospective observational study conducted at the Department of Cardiac Surgery, National Institute of Cardiovascular Disease, Dhaka, Bangladesh, over a 1.5-year period from April 2019 to September 2020 compared the outcomes of OPCAB and ONCAB in a Bangladeshi population, analyzing the demographic and clinical characteristics, operative characteristics, early postoperative outcomes, and recovery parameters of 34 patients undergoing either OPCAB (n=17) or ONCAB (n=17). Result: The two groups were well-matched in terms of demographic and clinical characteristics, with no significant differences in age, gender, BMI, or comorbidities. The OPCAB group had a significantly shorter total operative time (180.4 ± 26.8 min vs. 195.3 ± 31.2 min, P < 0.05). Early postoperative outcomes were similar between the two groups (P > 0.05 for all comparisons), while the OPCAB group had a significantly shorter hospital stay (7.8 ± 1.8 days vs. 9.2 ± 2.1 days, P < 0.05), mechanical ventilation time (9.1 ± 3.8 hours vs. 12.6 ± 4.5 hours, P < 0.05), and time to ambulation (3.8 ± 0.9 days vs. 4.5 ± 1.0 days, P < 0.05). Conclusion: Our study suggests that OPCAB may be a viable alternative to ONCAB for selected patients in the Bangladeshi population, offering potential benefits in terms of reduced recovery times and resource utilization. Further large-scale, randomized controlled trials are needed to confirm these findings and assess the long-term outcomes and cost-effectiveness of OPCAB compared to ONCAB.
A Rare Case of Peri-Anal Leiomyoma
Authors: Saad Benslimane , Ghani Manar , Zerhouni Ahmed , Souiki Tarik , Mazaz Khalid , Toughrai Imane , Majdoub Karim Ibn
Published: May 2023

Leiomyoma is a benign soft tissue tumor of mesenchymal origin that derives from smooth muscle fibers [1, 2]. In the digestive tract, the anorectal location is uncommon and is usually diagnosed late due to intraluminal growth in over 50% of the cases [2]. We present the case of a 55-year-old woman who presented with a peri anal mass found more than 3 years ago. The 5cmx4cmx3cm mass was located in the left side of the anus, MRI revealed a clear demarcation between the mass and the external anal sphincter. Surgery was performed with a para-anal incision. The external anal sphincter was largely intact. A complete extracapsular dissection was performed.
Conservative Treatment about Two Cases of Caustic Burns of the Upper Digestive Tract in Adults at the Sominé Dolo Hospital in Mopti
Authors: Adama Kondé , Alassane Diarra , Lamine Sidibé , Youssouf Fofana , Dramane Samake , Mamoutou Dembélé , Bréhima Traoré , Nana Dembélé , Djibril Traoré , Moussa Diarra , Anselme Konaté , Moussa Maïga
Published: May 2023

Emergency gastrointestinal endoscopy for patients who have ingested a caustic substance may overestimate burn injury and lead to unnecessary gastric resection. Caustic gastric lesions of stage III, without immediate life threat, do not systematically require an emergency total gastrectomy. This work was to evaluate the results of a conservative attitude of gastric stage III in two patients, by only proposing surgery in the presence of clinical, biological and radiological signs of severity. Reconstructive surgery and/or endoscopic dilation may be considered depending on the occurrence of strictures. We report two cases of caustic burn of the upper digestive tract in adults at the Sominé Dolo hospital in Mopti. Both patients were referred for surgery for partial gastrectomy with gastro - entero -anastomosis. The postoperative follow-up was simple and an endoscopic control carried out on D 15 and D 30 postoperatively did not find any obstacle at the level of the anastomoses. Cardial stenosis benefited from dilation sessions at a rate of 21 days until satisfaction.
Inflammatory Myofibroblastic Tumor of the Distal Bile Duct Mimicking Cholangiocarcinoma: A Case Report
Authors: Sekal Mohammed , Bennani Amal
Published: May 2023

Inflammatory myofibroblastic tumor has been described in various locations. However, its appearance in the periampullary region is uncommon and has rarely been reported in the literature. We report a case of a 37-year-old Moroccan male with painless jaundice and pruritus. Endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography showed a 2-cm-long stricture in the distal bile duct that suggests a cholangiocarcinoma. There was no involvement of adjacent structures at computed tomography of abdomen. The patient underwent a pancreaticoduodenectomy. The tumor histology showed regular spindle cells arrayed in fascicles, admixed with lymphocytes, plasma cells and eosinophils. Immunohistochemical analysis showed positive staining for smooth muscle actin, H-caldesmon. In contrast, the tumor cells did not express cytokeratin, PS100, CD68, CD23, CD117 and ALK. Based on these data, the diagnosis of inflammatory myofibroblastic tumor of distal bile duct was made. We report this new case in the aim of shedding more light on this entity and the challenges in making the diagnosis in such location.
Nutritional Status and Food Habit among School Going Adolescent of Bangladesh
Authors: Sutradhar Nandalal , Parveen Tanzina , Bhowmick Bristi , Anwar Md. Tanzir
Published: May 2023

Introduction: Adolescence is a time of high nutrient demands because of rapid growth and development during puberty. It is also a time when individuals experience increasing control over their food choices and develop dietary habits that affect their weight status and extend into adulthood. Objective: To assess the Nutritional status and food habit among school going adolescent of Bangladesh. Methods: A community based cross-sectional observational study was conducted in Savar Zilla School & Morning Glory School and College, Savar, Dhaka, Bangladesh from January to December 2022. A total of 100 students belonging to 8th, 9th and 10th classes participated. Information were collected regarding socio- demographic features and main eating habits from 10-19 years girls who were willing to participate and had no history of chronic illnesses like heart diseases, asthma, physically handicapped etc. Height and weight measurements were done by standard techniques and BMI was calculated using WHO Anthroplus software. BMI & Height for age were taken as a key indicator to assess their nutritional status. Data was analyzed by proportions, mean ± SD and χ2 test. Results: Mean age was 13.33 ± 1.09 years. Prevalence of thinness, overweight or obesity and stunting were 16%, 11.0% and 21.0% respectively. Significant association was found between different age groups, consumption of roots & tubers, cereals, puffed rice, green non-leafy vegetables, fatty foods, eating at fast food centre, skipping of meals, going hungry, physical activity, number of classes on healthy eating, trying to change their weight with the nutritional status of adolescent girls. Conclusion: There is a need to increase more nutritional counselling on healthy eating habits in school and thus to take appropriate interventions to improve the nutritional status of adolescent.