bluuebunny/crossref_metadata_2025 huggingface dataset:
GreenFILE
Authors: Duffy Jane C.
Published: April 2024

GreenFILE is an EBSCO database of scholarly, government, news, and general-interest titles covering renewable energy, green building (including net-zero construction), global warming, pollution, recycling, and sustainability. GreenFILE offers extensive coverage of records, including
indexing and abstracting services, in sustainability and other areas. The database contains more than one million records, with open access offered for more than 15,000 additional records. Searchable fields include standard fields, such as Abstract, Accession Number, and Author, as well as
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Table, Publications Authority File, and Thesaurus Authority File helpful in understanding the scope of the subjects and holdings afforded by this database. GreenFILE offers numerous tutorials designed for every level of researcher, from entry level to advanced.
A Viroinformatics Study: B-Cell Polytope Mapping of Envelope Protein to Develop Vaccine Candidate against Four DENV Serotype
Authors: Zainul Rahadian , Viol Dhea Kharisma , Lusia Utami Santika , Chandra Nelson , Muhammad Ansori Arif Nur , Syafri Edi , Wulandari Asri Peni , Illiandri Oski , Khoirun Nisyak , Bahrun Bahrun , A. R. Tasakka Asmi Citra Malina
Published: April 2024

Nowadays, dengue virus (DENV) is still become a global problem, even though the virus infection issues have reached half of the population in some countries each year. DENV belongs to the enveloped virus with positive-sense single-stranded RNA (+ssRNA) genus Flavivirus and belongs to the Flaviviridae family. DENV has structural proteins which consist of the envelope protein (E), capsid (C), and membrane (M). There are four serotypes of this virus which are DENV-1, 2, 3, and 4. These four serotypes are transmitted to humans through Aedes sp. The development of this vaccine is still in progress and the challenge of this DENV vaccine candidate design is to overcome the heterotypic infection and the expansion of coverage protection to all virus serotypes. This research uses design simulation for vaccine candidates using B cell epitope in all DENV’s serotypes envelope to trigger the antibody formation through bioinformatics method that consists of protein modeling, immunogenicity, toxicity, and immune stimulation. DENV envelope protein was predicted to have polytope that can be recognized by B cells and act as an antigen, have low similarity with the composing sequence of cell surface receptors on the body, and non-toxic, and then can trigger the population increase of B cell and IgM antibody production with high avidity to neutralize four of the DENV serotypes. We recommend the B cell polytype which consists of A, C, E, and G peptides be examined by the wet-lab approach.
Development and Validation of HPTLC and First Derivative Spectrophotometric Methods for Determination of Levetiracetam in Bulk and Tablet Dosage Form
Authors: Tayde Manisha A. , Patil Rupali A. , Katti Suvarna A. , Pawar Shubhangi H.
Published: April 2024

A simple, sensitive high performance thin layer chromatographic (HPTLC) method and first order derivative spectrophotometric methods were developed for estimation of US FDA drug levetiracetam in bulk and its tablet dosage form. Chromatographic estimation was carried out on silica gel 60 F245 TLC plate as stationary phase and toluene: methanol: Ethyl acetate (4:4:2v/v/v) as mobile phase. Densitometric analysis was carried out at wavelength 218nm. The Rf values for Levetiracetam was found to be 0.47±0.03. Linearity was observed over range of 400-3200ng/spot for Levetiracetam (R2 0.998). The %recovery of Levetiracetam was found to be 99.25-100.7%. The LOD and LOQ were found to be 0.0917ng/ml and 0.278ng/ml respectively indicating sensitivity of the method. The first order derivative spectra were obtained at n=4, Δλ=3nm and determinations was made at 215 nm using methanol as solvent. Linearity was observed in the range of 80μg/ml - 280μg/ml with good regression values. Percent mean recovery of Levetiracetam was obtained as 101.5%. Both proposed methods were simple, fast, accurate, precise and reproducible and hence can be applied for routine quality control analysis of levetiracetam in bulk and its tablet dosage form.
Effect of Extraction effectivity of Senna alata L. Leaves on the Total Phenolic, Antioxidative, Antimicrobial and Antigoat Activity
Authors: Candra Irawan , Foliatini Foliatini , Hindarto Cysilia K. , Sukiman Maman , Prastiwi Bening
Published: April 2024

Phytochemicals from natural product such as part of plants have been widely used as a potential source of herbal medication due to their bioactivity. Ketepeng cina (Senna alata L) is a small shrub that lives in tropical and subtropical regions and commonly used as medicinal plant to cure various diseases from infectious microbes. The current research was aimed to evaluate the extraction effectivity of Senna alata L leaves and the influence of the parameter to the total phenolic content, antioxidative, antimicrobial and antigout activity. Extraction of Senna alata L leaves was conducted by several methods, i.e maceration, ultrasonication and hot water extraction. The study revealed that each method give different yield of extraction and the most effective among those method is maceration, which produce highest yields of extracts (19.4%). Ultrasonic-assisted extraction (UAE) method also resulted in high yield but lower than that of maceration. The maceration method increases the yield by about 170% compared to hot water method. The extracts obtained from maceration method contain highest content of total phenolic (278.39mg GAE/g dry mass), thus demonstrate highest antioxidant activity (IC50 25.68mg/L), but lowest anti uric activity (reducing uric acid level by 85.25%). Maceration method was able to increase total phenolic content by about 128% and improve antioxidant activity by about 41%, compared to hot water method. However, UAE was excellent in producing phytochemicals which were responsible in anti uric activity, thus have the highest percentage in reducing UA level (90.72%), or increases by about 6.4%. compared to hot water method.
Determination of Genotoxic Impurities in Nilotinib using LC-MS Method
Authors: K Anil Kumar. , R. Sudha , Bavireddy Mohan , V D N Kumar Abbaraju , Kothakummari Smita
Published: April 2024

A validated HPLC method was developed for the determination of Nilotinib (Nob) in pharmaceutical formulation. Isocratic elution at a flow rate of 1.0ml/min was employed on Zorbax SB C18 5µm × 4.6mm, 150mm, or similar is used for this chromatography analysis and the column temperature is maintained as ambient. Mobile phase was a mixture of 2.00ml of acetic acid in 2000ml of water as mobile phase A and Acetonitrile 100% as mobile phase B was used. Rate of flow is identified at 1.3ml/min. a 50.0µl sample was injected. The run time is 20 minutes to Sample, blank, system suitability, and sensitivity solution. For the diluted standard solution, it is 60 minutes. The retention time was 1.30minutes. The% R.S.D Nob is identified. The mean percentage recovery for Nob is found within the specification limit. Due to this reason this proposed LC-MS method is successfully adopted to routine quality control analysis in formulations.
Development and Evaluation of Acitretin Loaded Solid Lipid Nanoparticles for Topical Drug Delivery System
Authors: Panmand P.A. , Mahaparale P. R. , Thorat V. P.
Published: April 2024

In order to understand the in vitro drug release of the produced gel, the goal of the current investigation was to construct and characterize. Acitretin loaded Solid Lipid Nanoparticles (ActSLNs). Act SLNs were created utilizing the Box Benhken design and the hot homogenization procedure. Act SLN's average diameter and surface morphology were assessed. Act SLNs were lyophilized, then they underwent stability testing, powder X-Ray diffraction, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) tests to characterize them. The SLNs were added to a 0.25% w/w Carbopol 940 gel base the Stability study, ex vivo drug release in vitro drug releases in rat skin were carried out. The optimized Act SLNs had a spherical form, an entrapment efficiency of 78.82% to 85.73%, and an average particle size of 123.24nm to 409nm. The generation of SLNs was confirmed by DSC, FTIR, and XRD data. ActSLN gel (0.056mg/cm2) significantly increased the amount of accutane deposited in rat skin compared to Act plain gel (0.012mg/cm2).No discernible change was found in the stability studies, according to stability studies.
Determination and Validation of pKa value of Atropine Sulfate using Spectrophotometry
Authors: Berkhout Job Herman , H.N. Aswatha Ram
Published: April 2024

The ionization state (pKa) of a compound influences its absorption, distribution, metabolism and excretion. Therefore, proper knowledge of the pKa is crucial in understanding the behavior of a compound behavior inside the body. In this research paper, we validate the pKa of muscarinic acetylcholine receptor antagonist atropine sulfate using Uv-Vis spectroscopy, to validate the use of this method and to re-evaluate the of atropine sulfate. The pKa value from absorption measurements is first estimated using 3rd degree polynomial and then precisely calculated according to the Albert-Sergeant method. We established that the pKa value of Atropine sulfate is 9.94±0.050 which is comparable to the values present in the literature.
Development and Validation of a UV Spectrophotometric Method for determination of Ondansetron hydrochloride in Bulk and Tablet Dosage Form
Authors: Shirole Prathamesh L. , Sanap Dhanashree P. , Jadhav Kisan R.
Published: April 2024

Our goal is to create and validate a UV Spectrophotometric method for estimating the Ondansetron HCL. According to ICH criteria, the procedure was verified. At 248.8nm, ondansetron has its highest absorption. Between 2 and 22g/ml, the linearity was noted. Recovery studies supported the analysis' findings. The findings of the validation parameters showed that the suggested technique was determined to be exact, precise, repeatable, sensitive, and appropriate for regular quality control analysis for estimation of ondansetron hydrochloride in solid dose formulation.
Monosodium iodoacetate induces Cartilage degradation and inflammation in rats in a dose- and time-dependent manner
Authors: Normasari Rena , Purwanto Bambang , Tinduh Damayanti
Published: April 2024

Monosodium iodoacetate (MIA) is a widely recognized agent for inducing cartilage degradation and inflammation in animal models. In this study, we systematically investigated the dose- and time-dependent effects of MIA on cartilage degradation in the knees of rats. We evaluated knee diameter, knee bend score, and the levels of pro-inflammatory cytokines (IL-1 and IL-8) and cartilage degradation markers (CTX-II) to gain insights into cartilage damage and inflammation progression. Wistar rats were categorized into groups receiving various doses of MIA via intra-articular injection (0.1 mg, 0.5 mg, 1 mg, 3 mg, and 5 mg) and were observed at multiple time intervals (2, 4, 6, 8, 10, and 12 weeks). We measured knee diameter to gauge joint swelling, assigned knee bend scores to assess functional limitations, and analyzed synovial fluid samples for IL-1β, IL-8, and CTX-II levels. Our data show that low-dose MIA increases pain sensitivity, knee diameter, inflammatory cytokines IL-1β and IL-8, and CTX-II levels, which progress slowly over 12 weeks. On the other hand, higher dosages of MIA caused cartilage deterioration after two weeks, followed by an increase in inflammatory cytokines. This research sheds light on MIA administration's dose- and time-dependent effects on cartilage breakdown and inflammation in rat knee joints. Analyzing knee diameter, knee bend score, IL-1β, IL-8, and CTX-II as evaluation parameters provides a multidimensional perspective of cartilage injury and inflammatory dynamics. These findings help us comprehend cartilage-related illnesses and have implications for future research on therapeutic approaches for cartilage disorders.
Secondary biliary cirrhosis caused by cyproterone acetate
Authors:   Hepato Gastroenterology Department, GHPSO, Creil, France., Cadrane Jean Francois
Published: April 2024

Cyproterone acetate (CPA) is an oral anti-androgen commonly used to treat advanced prostate cancer. A variety of hepatotoxic reactions has been reported with CPA. The aim of this report is to describe a well documented case of pateints treated with CPA and developing jaundice with a persistant anicteric cholestasis.
Plant-derived extracellular vesicles: A novel approach for gastrointestinal tract diseases
Authors:   Cellestetix Genetic Consultancy R D and Biotechnology Inc, Turkey., Canpolat erve Yıldırım
Published: April 2024

Exosomes, nanovesicles with diameters ranging from 30 to 150 nm are crucial for intercellular communication. They are produced by mammalian and plant cells to transport bioactive components such as proteins, nucleic acids, metabolites, and lipids, which vary based on their origin.
Approaches towards Attaining Net Zero Emissions in India: A Research Perspective
Authors: Dr. Nitin Saxena Dr. Surendra Tiwari, Dr. Puneet Kumar,
Published: April 2024

In order to accomplish India's lofty target of having net-zero carbon emissions by 2070, this article critically assesses the country's energy policy. The statement highlights the crucial significance of green electrification, including the extensive integration of solar power generation. It also explores non-energy sector strategies that are essential to achieving this goal, including smart use of information technology, infrastructure development, and improved transportation networks. It also looks at possible legislative avenues for accelerating the goal date to 2050, with a focus on utilizing carbon capture technology to ease the shift away from a strong coal dependency. It also looks at how various approach options would affect the economy and finances, arguing that India can achieve its net-zero goals without slowing down its economic growth trajectory if it receives reasonable financial support from abroad.
Measuring the advertising value of personalised ads in smartphones based on consumer literacy and privacy concerns
Authors: Vadapalani Campus Ms. Mythili R,
Published: April 2024

Because of the widespread use of smartphones in everyday life and advances in data analysis technology, brands are increasingly focusing on advertising via smartphone while collecting customer data. Advertisements are made to reach customers through two types of data collection: the first is using customer online behaviour to show personalised ads, which is known as online behavioural advertising (OBA), and the second is hearing out customer media usage and providing personalised ads, which is known as synced advertising (SA). The question here is whether personalised ads are useful and project a positive image to customers, which are reliable. The purpose of this paper is to provide a knowledge of how OBA and SA work and why it is vital to address personalised adverts in smartphones that are powered by AI algorithms due to privacy concerns. The purpose of this empirical investigation is to determine is purchase intention is accelerated based on the advertising value of personalised adverts, their literacy, and privacy concerns and to test the effect of personalised advertisement value on purchase intention.
Makna Pengampunan dalam Ritus Naketi pada Masyarakat Amanuban Timur dan Relevansinya terhadap Nilai-nilai Kristiani
Authors: Tlonaen Talita , Djawa Maya
Published: April 2024

Pengampunan merupakan kewajiban yang harus dilakukan dalam ritus naketi di Amanuban Timur. Namun pemaknaan pengampunan dalam ritus naketi belum dilaksanakan secara maksimal sehingga masyarakat belum memahami dengan benar apa yang seharusnya dilakukan dalam memberikan pengampunan dan memaknai pengampunan sesuai dengan kehendak Allah. Oleh karena itu, dalam penulisan ini akan dikemukakan makna pengampunan dalam ritus naketi di Amanuban Timur. Jenis penelitian ini adalah penelitian kualitatif, pendekatan fenomenologi. Teknik pengumpulan data adalah dengan cara observasi, wawancara serta domunetasi dan dokumen-dokumen. Hasil penulisan ditemukan bahwa tujuan utama dari ritus naketi adalah untuk merefleksikan diri, memperbaiki kesalahan yang dilakukan dan memperdamaikan diri dengan sesama maupun Tuhan sebagai bentuk pemulihan relasi. Pemaknaan pengampunan dalam ritus nakekti harus ditandai dengan adanya perdamaian dalam diri sendiri, sesama dan Tuhan sebagai pencipta. Mengampuni berarti merefleksikan diri atas kesalahan yang dilakukan, memaafkan kesalahan yang dilakukan tanpa adanya kepahitan dalam diri dan mampu mengaplikasikan pengampunan yang diberikan oleh Yesus Kristus sebagai bentuk ucapan syukur atas anugerah yang diterima tanpa menuntut balasan.
Investigation of Potential Protective effects of Betanin on experimental Monosodium Glutamate–induced toxicity in Elderly rats
Authors: Baytar Gurkan , Kutlu Tuncer , Ogut Serdal
Published: April 2024

This study was conducted to investigate the protective effects of Betanin active ingredient in red beetroot plant (Beta vulgaris) in elderly rats exposed to chronic toxicity of monosodium glutamate (MSG). A total of 48 elderly rats were randomly divided into 4 different groups. At the end of the 28–day study, the rats were sacrificed under deep anesthesia. Total antioxidant capacity (TAC), total oxidant capacity (TOC), paraoxonase (PON), thiol, malondialdehyde (MDA), and nitric oxide (NO) levels were investigated in rat blood serum using the spectrophotometric method. Oxidative Stress Index (OSI) was calculated by dividing TOC by TAC. Total bilirubin was measured with the colorimetric method using an ELISA kit. Liver tissues were stained with hematoxylin–eosin (HE) for histopathological examination. The difference in serum levels of TAC, TOC, OSI, PON, MDA, and thiol was statistically significant between the groups (P<0.05). The difference in serum levels of NO and total bilirubin was not statistically significant between the groups (P>0.05). The analysis of histopathological findings revealed uncommon mild hydropic degeneration in the MSG group and almost normal histological appearance in the MSG+Betanin group. This study demonstrated that betanin could increase the antioxidant effect and reduce the histopathological damage caused by MSG.
Tipificación energética de productores ganaderos del trópico seco de Chiapas, México
Authors: Guevara–Hernández Francisco , La O–Arias Manuel Alejandro , Aguilar–Jiménez José Roberto , Pinto–Ruiz René , Venegas–Venegas José Apolonio , Cadena–Iñiguez Pedro
Published: April 2024

El desarrollo de la ganadería bovina está asociado a un conjunto complejo de factores que determinan su grado de intensificación y eficiencia. Los estudios sistémicos a partir del balance energético y sus flujos permiten identificar puntos críticos para la mejora socioproductiva a través de la innovación, comprender la racionalidad productiva del ganadero y evaluar el desempeño general del agroecosistema. El propósito de este estudio fue llevar a cabo la tipificación energética de los productores ganaderos de doble propósito en tres municipios de la región Frailesca de Chiapas, México. La investigación, realizada en Villaflores, Villa Corzo y El Parral, se caracterizó por su enfoque descriptivo y exploratorio con una perspectiva sistémica. La muestra consistió en 420 productores ganaderos seleccionados aleatoriamente en los tres municipios. La obtención de información primaria se llevó a cabo mediante entrevistas semi–estructuradas, observación y revisión de registros productivos, para lo cual, se utilizaron indicadores como superficie agropecuaria, tamaño y estructura del hato, producción, productividad por área y eficiencia energética. Se identificaron cinco grupos de productores o tipos de sistemas ganaderos de doble propósito. Los grupos I al IV, se diferenciaron por la escala de su producción, en los que se observaron niveles de intensificación variables, mientras que el quinto grupo, exhibió sistemas más intensivos con niveles de productividad de igual forma variables. Los sistemas intensivos evidenciaron una menor eficiencia energética, con un promedio de 0,5, debido a la alta carga de entradas energéticas en forma de alimentos concentrados y voluminosos. Por su parte, el resto de los sistemas mantuvieron eficiencias energéticas entre 1 y 2.
Podmiot przestępstwa z art. 302 § 1 k.k.
Authors: Troczyński Krzysztof
Published: April 2024

The article concerns the issue of subject of crime of art. 302 § 1 of Polish Penal Code. The vital topics which are argued by judiciary and doctrine of penal law are whether is it possible to put criminal liability on person responsible for someone else’s debt. Another question is about relation between the change of legal good protected by abovementioned crime and its interpretation in thematter of subject of crime.
Glosa do wyroku Sądu Najwyższego z dnia 5 grudnia 2023 r., I KK 255/23
Authors: Kłak Czesław
Published: April 2024

The commentary concerns the possibility of issuing a penal order in a Polish criminal trial. The Supreme Court rightly pointed out that the court may issue a penal order judgment if, based on the evidence collected, the circumstances of the act and the guilt of the accused do not raise any doubts, and the lack of such doubts means that there are no doubts regarding the perpetration of a given act, the guilt of the accused, and the fulfillment of all the features of this act, taking into account all the evidence presented in the indictment. However, we cannot agree with the Supreme Court’s comment that the lack of a confession by the accused makes it impossible to issue a penal order.
Spontaneous rupture of 90 mm splenic epidermoid cyst with subcapsular splenic hematoma and hemoperitoneum
Authors: Yi Goai Xin , Chang Wendy , Htut Zaw Myo , Jean Beardsley Christian , Francois Pretorius Casper
Published: April 2024

Introduction: This report explores the rare occurrence of spontaneous splenic rupture in a healthy individual, attributed to a benign epidermoid splenic cyst.

Case Report: The patient, a 28-year-old male, presented with one-week history of abdominal pain due to ruptured splenic cyst leading to subcapsular splenic hematoma and hemoperitoneum without any traumatic history nor underlying conditions. The diagnostic journey, including CT scans, guided the decision for splenectomy. Postoperative recovery was uneventful, with histopathological examination identifying an epidermoid cyst.

Conclusion: This case emphasizes the importance of recognizing atraumatic splenic ruptures, even in the absence of underlying conditions, and underscores the significance of prompt intervention through techniques like splenectomy.
Tutoring in Mathematics and Education and Everything in between
Authors: Sultan Simon
Published: April 2024

In this period, we witness the importance of education and teaching as a means of shaping people, if unfortunately for the purposes of inciting hatred or terrorism, and on the other hand, shaping a better person through a change of direction. As we have seen, education and teaching have great power in influencing the shaping of people: value-wise, morally, proportionately, culturally and educationally. When I turn to many people and ask: “What do you think will happen if you talk to one child at home and the rest are passive?”. Everyone’s reaction is shock and then: “What happened, you’ve gone crazy, it will be terrible”. In light of this, it is clear to everyone that the continuation of teaching in the frontal/traditional approach in mathematics in general, in which about 85% of the students are passive and the teacher presents the solutions and not the way of thinking and guiding the solution process, must stop. The article emphasizes the need to analyze one’s own thoughts when applying different methods and when solving practical tasks of a different nature.
Colección Resumen de las Actas de la Comisión de Monumentos y Patrimonio Histórico. Número 1, sesión 15 de enero de 2024.
Authors: Comisión de Monumentos y Patrimonio Histórico
Published: April 2024

Sesión 15 de enero de 2024.
Relación de los asuntos tratados:
1. Aprobación del acta, si procede, de la reunión anterior, p. 2.2. Votación para la designación de los cargos de Presidente y Secretario de la Comisión, pp. 2-3.3. Solicitud por parte de la Dirección General de Patrimonio Cultural y BellasArtes del Ministerio de Cultura de informe relativo al Faro del Cabo de Palos enCartagena (Murcia) para su posible declaración como BIC, p. 3.4. Solicitud por parte del Gobierno del Principado de Asturias de informe sobrepropuesta de declaración BIC al Conjunto Patrimonial de LOS SELGAS, en ELPITU, Cudillero (Asturias), p. 3.5. Comunicación del Departamento de Euskera, Cultura y Deporte de la DiputaciónForal de Bizkaia relativa al Puente de Udondo, p. 3.6. Noticias: Cocheras de Metro de Cuatro Caminos, Frontón Beti-Jai, Valle de losCaídos y Edificio Castelar, p. 3.7. Dos informes de Pedro Moleón, pp. 3-4.
Use of potentially inappropriate medications and medications of concern in older adults with multiple myeloma
Authors: Silva Paulo Vitor Rozario da , Pádua Cristiane Aparecida Menezes de , Machado Taisa Roberta Lopes , Drummond Paula Lana de Miranda , Silveira Lívia Pena , Malta Jéssica Soares , Reis Adriano Max Moreira
Published: April 2024

Objectives: To analyze the use of potentially inappropriate medications (PIMs) and medications used in supportive therapy that require caution in older adults with cancer, in addition to determining associated factors the agreement between criteria sets used to identify PIMs. Methods: This cross-sectional study included individuals with multiple myeloma aged ≥ 60 years who were undergoing outpatient treatment. PIMs were identified according to American Geriatric Society Beers 2019, PRISCUS 2.0, and Brazilian Consensus on Potentially Inappropriate Medicines criteria. Medications of concern were defined according to National Comprehensive Cancer Network criteria. Factors associated with the use of PIMs and medications of concern were identified using multiple logistic regression. The degree of agreement between the 3 criteria sets was measured using Cohen’s kappa coefficient. Results: The frequency of PIM use was 52.29% according to American Geriatric Society Beers criteria, 62.74% according to Brazilian Consensus criteria, and 65.36% according to PRISCUS criteria, while 52.29% of the patients were using medications of concern. Agreement between American Geriatric Society Beers, PRISCUS, and Brazilian Consensus criteria was high, while it was excellent between Brazilian Consensus and PRISCUS criteria. In the final logistic regression model, polypharmacy was associated with PIM use according to each criteria set, as well as the use of medications of concern. Conclusions: The frequency of PIMs and medications of concern was high. Agreement about PIM use between the American Geriatric Society Beers, Brazilian Consensus, and PRISCUS criteria was high or excellent. There was an independent association between polypharmacy and the use of PIMs and medications of concern by older patients with multiple myeloma.
The ICOPE-WHO and the IVCF-20: a critical view of the Handbook for Multidimensional Geriatric Assessment in Primary Care
Authors: Lourenço Roberto Alves , Mello Renato Gorga Bandeira de , Ferretti-Rebustini Renata Eloah de Lucena , Oliveira Vitor Pelegrim de , Ferriolli Eduardo
Published: April 2024

Rapid population aging is driving initiatives aimed at optimizing the health of older populations worldwide. In Brazil, the National Council of State Secretaries of Health (CONASS) recently published the Handbook for Multidimensional Geriatric Assessment in Primary Care, which proposes the combined, large-scale adoption of the World Health Organization (WHO) ICOPE screening tool and the Clinical-Functional Vulnerability Index-20 (IVCF-20) instrument to define care pathways for older people. Although there is a pressing need for initiatives of this nature, the proposed instruments have not yet been adequately validated in the Brazilian population, and their use for the purpose of establishing countrywide health guidelines appears hasty and risky. Therefore, we propose a broad, urgent debate among experts in the field with the aim of planning effective and safe public health policies for the Brazilian older population.
Pseudotallos y feromonas en capturas de Cosmopolites sordidus (Coleoptera: Curculionidae) en huertos de plátano del municipio de Tecomán, Colima, México
Authors: Rauda-Cárdenas Gil , Hernández-Ortega Herminia Alejandra , Sánchez-Rangel Juan Carlos , Castrejón-Antonio Jesús Enrique
Published: April 2024

Objetivo. Evaluar cuatro trampas para capturar Cosmopolites sordidus en huertas de banano en Tecomán, Colima. Materiales y métodos. Se realizó un estudio durante octubre 2022 a febrero 2023 empleando un diseño experimental en bloques, evaluando cuatro tratamientos: dos trampas artesanales una con feromona y otra con material vegetal, y dos con pseudotallo de plátano. Se registraron las capturas semanalmente. Resultados. La trampa con feromona capturó en promedio 7.9 insectos/semana, la artesanal con material vegetal 1.5 y las de pseudotallo 4.0. Conclusión. La trampa con feromona es más efectiva para capturar C. sordidus en cultivos de plátano.
Palabras clave: atrayentes, coleoptera, manejo, sordidin, trampas
Investigation of the presence and enzymatic activity of fungi in stored corn (Zea mays L.) and soybean [Glycine max (L.) Merrill] grains
Authors: Silva Eduarda de Macêdo , Freire Antonia Fábia do Nascimento , Figueira Felipe da Silva , Sousa Aurizangela Oliveira de , Paiva Maykon Jhuly Martins de , Alexandrino Bruna , Santos Taides Tavares dos
Published: April 2024

Soy [Glycine max (L.) Merrill] and corn (Zea mays L.) are important crops in Brazilian agribusiness. When stored improperly, these grains are susceptible to insects and microorganisms. Among the microorganisms capable of causing grain deterioration, fungi stand out. Despite the harm associated with fungi, they are biotechnologically appreciable due to their potential ability to produce hydrolytic enzymes, such as cellulases and proteases. Fungal hydrolytic enzymes have been applied in various processes in the food, textile, and detergent production industries, among others. The objective of this study was to verify the presence of fungi in samples of corn and soybean grains under storage conditions and characterize them regarding the production of cellulolytic and proteolytic enzymes. Among the results, there was a greater quantity and variety of filamentous fungi (35 morphotypes) in association with the grains evaluated, than of yeasts (three morphotypes). Representatives of the genera Aspergillus spp., Curvularia sp., and Penicillium spp. were detected, corroborating previous reports in the literature. Filamentous fungi that tested positive for cellulase production had an enzyme ratio index (ERI) varying between 1.06 and 2.57 (mean ± standard deviation = 1.37 ± 0.48), while for proteolytic activity, only the fungi isolated from soybean tested positive, with ERI (mean ± standard deviation) = 1.21 ± 0.01. Although the taxonomy of the isolates in this study has not been completely elucidated, it is possible to state that these fungi are promising for producing hydrolytic enzymes, with potential for use in the development of products and/or biotechnological processes.
A construção de uma nova institucionalidade para a rede federal de educação profissional e tecnológica em tempos da acumulação flexível
Authors: Barbosa Sebastião Cláudio , Castro Mad’Ana Desirée Ribeiro de
Published: April 2024

Este trabalho de pesquisa analisa, a partir de revisão bibliográfica e documental, que são expedientes considerados necessários para averiguação de mudanças propostas e implementadas no âmbito educacional, a constituição de uma nova institucionalidade para a Rede Federal de Educação Profissional e Tecnológica, a  partir dos pressupostos estabelecidos pela perspectiva do neoliberalismo e pela atual reestruturação produtiva, baseada na acumulação  “flexível” do capital. Adotou-se nesse escrito o método materialista histórico e dialético de análise, uma vez que se considera as categorias totalidade, mediação e contradição como necessárias para apreensões que envolvam a realidade, no caso, educacional. Neste sentido, e de maneira histórico-crítica, destaca a construção dos Centros Federais de Educação Tecnológica (CEFETs) e dos Institutos Federais de Educação, Ciência e Tecnologia (IFs) e as suas configurações. Considera-se, dentre outras determinações, o ser e o estar dessas mudanças, uma vez que manter aspectos entendidos como democratizadores e/ou emancipatórios nos textos não condizem, necessariamente, com o processo prático que envolve o cotidiano dessa construção. Ademais, o texto se esforça para desvelar quais os princípios e finalidades que motivam as demandas por mudanças. Verifica-se, por meio da consideração das mediações e contradições que ocorrem no processo, que, apoios e ações aparentemente coincidentes, supostamente apontadas para objetivos comuns, vislumbram reconstruções ou construções societais divergentes, não apontadas para o aprofundamento da democratização da instituição. Por fim, pondera-se que o processo de construção da nova institucionalidade dos IFs deve ser problematizado a partir da compreensão de qual desenvolvimento de nação está em curso e quais contradições estão colocadas.
Gestural Simulation of Motion Verbs
Authors: Khatin-Zadeh Omid , Hu Jiehui , Eskandari Zahra , Yanjiao Zhu , Farsani Danyal , Banaruee Hassan
Published: April 2024

We aimed to investigate how the path of a motion verb is mentally simulated and realized in gestures when it is encoded in path-joined motion verbs (e.g., “enter the house”), path-disjoined motion verbs (e.g., “go into the house”), and pathless motion verbs (e.g., “walk in the street”). We conducted 2 studies to answer this question. In Study 1, we analyzed gestures produced by presenters in a set of YouTube videos. We used several chi-square tests to find out what type of gesture (path representational, non–path representational, beat, pointing gestures, and no-gesture) co-occurred more frequently with path-joined, path-disjoined, and pathless motion verbs. In Study 2, we analyzed gestures produced by a group of participants in a story-retelling setting. Both studies showed that path representational gestures co-occurred more frequently with path-joined motion verbs than path-disjoined and pathless motion verbs. Furthermore, the probability of using a path representational gesture with a path-joined motion verb having a human subject was higher than that having a nonhuman subject. Although the language difference in Study 1 and Study 2 might be a limitation, the consistency of results of the 2 studies suggests that the findings are generalizable. We suggest that gestural simulation of a motion verb is affected by how the direction or path of motion is encoded in the verb. When the path of motion is encoded in the main part of the verb, the motion and its path or direction are simultaneously simulated. This account implies that the motor system plays an active role in the process of simulating the path.
Intervention Bias: People Overpredict Social Problems in Which They Believe Society Can Intervene
Authors: Rigoli Francesco
Published: April 2024

Evidence indicates that when people forecast potential social risks, they are guided not only by facts but often by motivated reasoning also. Here I apply a Bayesian decision framework to interpret the role of motivated reasoning during forecasting and assess some of the ensuing predictions. In 2 online studies, for each of a set of potential risky social events (e.g., economic crisis, rise of income inequality, and increase in violent crime), participants expressed judgments about the probability that the event will occur, how negative occurrence of the event would be, whether society is able to intervene in the event. Supporting predictions of the Bayesian decision model, the analyses revealed that participants who deemed the events as more probable also assessed occurrence of the events as more negative and believed society to be more capable to intervene in the events. Supporting the notion that a social threat is appraised as more probable when an intervention is deemed to be possible, these findings are compatible with a form of intervention bias. These observations are relevant for campaigns aimed at informing the population about potential social risks such as climate change, economic dislocations, and pandemics.
Trabalhabilidade, empregabilidade e desenho de trabalho do ponto de vista dos servidores de uma instituição de ensino superior
Authors: Ramos Pamela , Gomes Débora Raquel Ferreira da Silva , Pereira Felipe Araujo
Published: April 2024

O ser humano, desde eras remotas, já desempenhava funções de trabalho. O que era apenas para sobrevivência tornou-se, após a Revolução Industrial, uma oportunidade de desenvolvimento financeiro. A empregabilidade é um conceito que define o que é necessário para que um colaborador seja visto como valioso pelo mercado de trabalho. Enquanto a "trabalhabilidade" surgiu para estudar a capacidade desses empregados em gerar renda. Esta pesquisa teve como propósito estudar a trabalhabilidade e empregabilidade dos docentes e técnicos administrativos da Universidade Federal da Paraíba (UFPB), buscando entender a importância e o impacto de cada dimensão do trabalho na vida do público-alvo, por meio da aplicação de um questionário sobre o desenho do trabalho, analisado pelo software SPSS. O objetivo era compreender critérios como a quantidade de informações que esses colaboradores filtram para desempenhar suas funções, a política de feedbacks, eficiência dentro da organização e a interdependência profissional. Constatou-se que 70% dos técnicos e docentes da UFPB não possuem interdependência profissional, 73% dos respondentes afirmaram que filtram diariamente uma alta gama de informações e apenas 54% afirmam receber feedbacks de colegas sobre seu desempenho profissional. Esses resultados estão diretamente relacionados a três das cinco dimensões do WQD: autonomia, variedade de trabalho e feedback no trabalho. Por meio desses resultados, identificou-se a influência e importância dos princípios da trabalhabilidade e empregabilidade e do desenho de trabalho no público-alvo da pesquisa, bem como a possibilidade de ampliação desta pesquisa para outras instituições de ensino.
Impact assessment of COVID-19 response policy measures on informal employment in Argentina
Authors:   International Labour Organization,
Published: April 2024

The COVID-19 pandemic left no country untouched and caused significant economic disruption worldwide. In this context, the ILO reaffirmed its commitment to leave no one behind, especially the most vulnerable (women, youth, the poor). To counteract the negative effects of the pandemic, governments have implemented various economic policies. In spite of macroeconomic constraints, the Argentine government quickly launched several aid packages to support the economy, formal employment and income. To assess the effectiveness of these policies in Argentina as a case study, a multi-sector recursive-dynamic structuralist CGE model of the Argentine economy - labour market informality and gender gaps - has been developed. It is calibrated using an informality and gender-sensitive social accounting matrix for Argentina in 2018, with the associated satellite account of employment. This model allows for an ex-post evaluation of the policy measures in the short and long term. The results show that the policy packages were successful in mitigating the negative effects of the pandemic and also paved the way for economic recovery, preserving formal employment and female labour force participation.
GPT-4 TURBO: EXPANDING THE BOUNDARIES OF ARTIFICIAL INTELLIGENCE THROUGH API INTEGRATION
Authors: Tanatova B. R. , Kulikov V. P.
Published: April 2024

GPT-4 Turbo represents a new milestone in the development of artificial intelligence (AI), providing unique opportunities for API integration into proprietary developments. This algorithm, based on the GPT-4 architecture, not only improves the quality of natural language, but also provides high performance and efficiency in a wide variety of tasks. In this article, we will look at the key characteristics of the GPT-4 Turbo, as well as consider the prospects for its implementation through the API in various areas.
DEVELOPING STUDENTS' ABILITIES TO WORK WITH TEXT
Authors: Atygayeva K. M. , Koshanova Zh. T. , Yersainova A. B.
Published: April 2024

This article talks about the formation of students' ways of working with professional texts in the Kazakh language in Russian-speaking groups. Because the effectiveness of new methods is always important. The author focused on the formation of speaking, writing, reading and listening skills of students in their specialty. The article not only gives tasks revealing aspects and subtleties of jurisprudence, but also contains information aimed at studying new terms. When writing the article, the authors paid special attention to tasks in the speech direction when working with the text, because they: develop mental activity; contribute to the formation of the use of the studied vocabulary and grammatical categories used in syntactic constructions. In the article, since the authors intend to form the mutual speech of students in their specialties, many tasks are set to create role-playing interviews, the ability to compose their own interviews using the example of ready-made interviews. There is also a training method, because any education begins with training. Scientific significance of the research work: the article contributes to the development of the Kazakh language in higher educational institutions. And practical significance: the results of the study can be used as additional educational material in practical classes.
DISTRUBTION OF MEDICINAL PLANTS OF KYZYLZHAR DISTRICT OF NORTH KAZAKHSTAN
Authors: Kezheneva D. D. , Tleubergenova G. S. , Galaktionova E. V.
Published: April 2024

The research work is devoted to the study of the biodiversity of medicinal plants of the Kyzylzhar district of the North Kazakhstan region. The distribution of medicinal plants of the Kyzylzhar district of the North Kazakhstan region is given. We have considered 16 types of medicines common in the Kyzylzhar district. Based on our research, pharmacological properties of medicinal plants based on Turova A.N. and Sapozhnikova E.N. were identified: medicinal plants affecting tissue metabolism, acting in diseases of the liver and bile ducts, respiratory organs, digestive organs, cardiovascular diseases, the nervous system and medicinal plants used in gynecology. The most numerous pharmacological group are medicinal plants that act in diseases of the digestive system, they include 5 types of medicinal plants. Medicinal plants that act in diseases of the liver and biliary tract, cardiovascular diseases, the nervous system accounts for 1 medicinal plant. Locations are marked for 16 types of medicinal plants at the Kyzylzhar district of the North Kazakhstan region. Among them there is one species of rare plants: Adonis vernalis L.
SUBCLASS LAMIIDAE TAXONOMIC COMPOSITION OF THE «BIOLOGY» DEPARTMENT HERBARIUM COLLECTION OF THE M. KOZYBAEV NORTH KAZAKHSTAN UNIVERSITY
Authors: Romanchuk V. V. , Tleubergenova G. S.
Published: April 2024

Herbarium collections are one of the most important tools for studying the biological diversity of the flora, giving an idea of the morphological structure of plants and floristic composition of biocenoses. The research work is devoted to the study of taxonomic composition of the subclass Lamiaceae (Lamiidae) in the herbarium collection of the Department of "Biology" SKU named after M. Kozybaev. The study is based on the inventory, determination of taxonomic identity of herbarium specimens. According to the results of the study 4 families, 34 genera and 50 species were described. The article presents data on the species composition of representatives of 4 families: Boraginaceae Juss., Labiatae Juss., Solanaceae L. and Scrophulariaceae Juss. The analysis of the collected data allowed to establish the degree of herbarization coverage of the species composition of the subclass Lamiidae in the North-Kazakhstan region and indicated the trajectories of herbarium fund completion.
THE WORKS OF MAGZHAN ZHUMABAYEV AND MAXIM GORKY - A SOURCE OF PATRIOTIC UPBRINGING
Authors: Shaukerova S. N.
Published: April 2024

This article addresses the issue of educating students about high and valuable moral qualities through the heroes portrayed in literary works. It highlights the importance of instilling universal personal values in students, values that significantly influence the formation of an individual's character and personality as a whole. Presently, the primary requirements of modern education involve nurturing a generation with a sense of patriotism, a high level of spiritual thinking, and a strong sense of responsibility. The significance of utilizing the works of Magzhan Zhumabayev and Maxim Gorky in patriotic education is underscored. Darkness and light, East and West, heroism and betrayal, life and death coexist within the creativity of these writers. The comparative method reveals the richness of the heroes' souls, their strength, and courage. The artistic thinking system harmonizes well with associative connections, philosophical, and psychological characteristics. A distinctive feature of patriotism lies in observing a high degree of national-artistic consciousness and personal development in individuals.Through the artistic images depicted in these works, there emerges an opportunity to understand individuals, their environment, and their inner experiences. These methods of portraying characters in literary literature enhance students' logical thinking skills.The power of these works lies in their ability to strengthen the national spirit in youth and elevate the sense of patriotism.
THE SPIRITUAL CRISIS OF MODERN SOCIETY
Authors: Aubakirova S. S. , Fedossova E. V.
Published: April 2024

The article is devoted to the problems resulting from the modern spiritual crisis, as well as the search for ways to overcome this systemic crisis. Turning to the meaning of the concept of spirituality, the authors of the article considers a number of possibilities for overcoming the state of spiritual crisis, among which the desire for human values is indicated. The reasons and types contributing to overcoming, explaining the spiritual crisis and affirming the further growth and uplift of spirituality in all its manifestations are analyzed.