bluuebunny/crossref_metadata_2025 huggingface dataset:
PLAG1 g.8795C>T Mutation Regulates Early Body Weight in Hu Sheep by Weakening miR-139 Binding
Authors: Wang Yue , Li Yin-xia , Zhang Jun , Qian Yong , Meng Chun-hua , Zhong Ji-feng , Cao Shao-xian
Published: February 2023

Sheep birth and weaning weights indicate their growth and survival. Thus, identifying molecular genetic markers for early body weight is important in sheep breeding. Pleomorphic adenoma gene 1 (PLAG1) is important for regulating birth weight and body length in mammals; however, its relationship with sheep body weight remains unknown. Here, the 3′-untranslated region (3′-UTR) of the Hu sheep PLAG1 gene was cloned, single nucleotide polymorphisms (SNPs) were screened, genotype–early body weight relationships were analyzed, and the possible molecular mechanism was explored. PLAG1 3′-UTR sequences with five forms of base sequences plus poly(A) tails were detected in Hu sheep and the g.8795C>T mutation was identified. Luciferase reporter assay indicated that the g.8795C>T mutation influenced PLAG1 post-transcriptional activity. miRBase prediction showed that the g.8795C>T mutation was located in the miR-139 seed sequence binding region, and miR-139 overexpression significantly decreased both PLAG1-CC and PLAG1-TT activities. Moreover, the luciferase activity of PLAG1-CC was significantly lower than that of the PLAG1-TT, but miR-139 inhibition substantially increased both PLAG1-CC and PLAG1-TT luciferase activities, suggesting that PLAG1 is the target gene of miR-139. Thus, the g.8795C>T mutation upregulates PLAG1 expression by weakening its binding with miR-139, promoting PLAG1 expression, and increasing Hu sheep birth and weaning weights.
Holocene Paleoenvironmental Implications of Diatom, Non-Pollen Palynomorph, and Organic Carbon Records from the Kandalaksha Bay of the White Sea (European Arctic)
Authors: Polyakova Yelena , Agafonova Elizaveta , Novichkova Ekaterina , de Vernal Anne
Published: February 2023

Variations in sea surface conditions and sea level through the Holocene in the Kandalaksha Bay, the White Sea, were reconstructed based on the study of core sediments from the outer Kandalaksha Bay, using the modern analog technique applied to dinocysts in addition to diatoms, TOC, δ13Corg, CaCO3, and grain size data. The chronostratigraphy of the core sediments was defined from accelerator mass spectrometry 14C dates on mollusk shells. The results indicated an increase in water depth in the outer Kandalaksha Bay and in the central Dvina Bay until the late Holocene. From about 9.5 to 7.5 cal kyr BP, the data suggested a general trend of increasing sea surface temperatures (up to 14 °C), at least in areas with inflow of Atlantic waters. The last 2.5 kyr were characterized by increased freshwater runoff to the White Sea.
Providing Diabetes Education through Phone Calls Assisted in the Better Control of Hyperglycemia and Improved the Knowledge of Patients on Diabetes Management
Authors: Kundury Kanakavalli K. , Bovilla Venugopal R. , Kumar K. S. Prathap , Chandrashekarappa Smitha M. , Madhunapantula SubbaRao V. , Hathur Basavanagowdappa
Published: February 2023

Purpose: A recent single-arm pilot study from our group showed a significant decrease in HbA1C in Type-2 diabetes individuals provided with SMS and phone call-based education on glycemic control. Considering the preference of participants to phone call-based education, a randomized control trial (RCT) with parallel design was conducted to determine the impact of phone call-based diabetes educational intervention on the control of hyperglycemia and improvement in the knowledge about diabetes management. Objectives: To determine the impact of phone call-based educational intervention on the control of hyperglycemia and improvement in the knowledge about diabetes management. Methodology: The study was conducted for a period of 12 months on a total of 273 Type-2 diabetic patients (interventional group (n = 135); non-interventional group (n = 138)) who had provided consent to participate. Subjects in the case group received weekly phone calls on diabetes education; whereas the control group received no education. HbA1C investigations were carried out at baseline and at every fourth month until the completion of the study period for the subjects in both the groups. The impact of phone call-based education was measured by comparing HbA1C values as well as by measuring the questionnaire-based knowledge scores on diabetes management. Results: At the end of the study period, there was a significant reduction in HbA1C in 58.8% participants (n = 65) and a manifold (2–5-fold) increase in knowledge on diabetes management among participants in the case group (n = 110). However, no significant difference in HbA1C and knowledge score was observed in participants from the control group (n = 115). Conclusion: Phone call-based diabetes education is a viable option to empower patients for better management of Type-2 diabetes.
Gender, Mental Health and Socioeconomic Differences in Fibromyalgia: A Retrospective Cohort Study Using Real-World Data from Catalonia
Authors: Sauch Valmaña Glòria , Miró Catalina Queralt , Carrasco-Querol Noèlia , Vidal-Alaball Josep
Published: February 2023

The main objective of our study was to assess the associated risk between fibromyalgia (FM) and the incidence of the diagnosis of anxiety and depression in the general population during the years 2010–2017 in Catalonia. Method: A retrospective cohort study was designed using the Information System for Research Development in Primary Care database. All patients with FM were included (n = 56,098) and matched to the control group in a 1:2 pairing ratio (n = 112,196). The demographic variables studied were sex, age and socio-economic status. Results: Patients with FM have a lower survival rate if they are also diagnosed with anxiety and depression during the entire study period, with the rate being 26.6% lower in FM patients at an 8-year follow-up (0.58, 95%CI: 0.57–0.59 vs. 0.79, 95%CI: 0.78–0.79). There is a 58% reduction in the risk of developing anxiety and/or depression in the control group vs. the FM group (p-value < 0.05), and by 45% in male vs. female sex (p-value < 0.05). Conclusions: FM is a disease that is associated with anxiety and depression, and men are at lower risk of anxiety and depression after FM diagnosis.
Knowledge of, Attitudes towards, and Practices of Intranasal Corticosteroids Usage among the Allergic Rhinitis Patients of Northern Saudi Arabia: A Cross-Sectional Study
Authors: Al-Rasheedi Abdullah N.
Published: February 2023

Intranasal corticosteroids (INCS) are generally safe and effective treatments for allergic rhinitis (AR). The improper use of INCS may not alleviate AR symptoms, and it could lead to complications and an impaired quality of life. We evaluated the knowledge of, attitudes towards, and practices of INCS usage and associated factors among AR patients using a pretested Arabic questionnaire. Of the 400 participating AR patients, 39.3%, 29.0%, and 36.5% had poor scores for knowledge, attitude, and practice, respectively. We found a significant association between knowledge and education (p < 0.001) and follow-up facilities (p = 0.036). The attitude category was significantly associated with age (p = 0.003), marital status (p = 0.004), and type of allergic patients (p < 0.001), and the practice category was significantly associated with education (p = 0.027), type of allergic patients (p = 0.008), and follow-up facilities (p = 0.030). Smoking status was significantly associated with all three categories. Furthermore, we found a positive correlation between knowledge and practice scores (Spearman’s rho of 0.451, p < 0.001). We recommend improving AR patients’ knowledge of the proper practices of INCS through health education programs. Furthermore, we recommend an exploratory mixed-method survey on the INCS usage among AR patients that involves other provinces in the KSA.
Health-Related Quality of Life and Healthcare Events in Patients with Monotherapy of Anti-Diabetes Medications
Authors: Abegaz Tadesse Melaku , Ali Askal Ayalew
Published: February 2023

This study aimed to examine the difference in health-related quality of life (HRQOL) and diabetes-related healthcare events (HCEs) among adults with diabetes who were on metformin, sulfonylurea, insulin, or thiazolidinedione (TZD) monotherapy. The data were sourced from the Medical Expenditure Panel Survey (MEPS). Diabetes patients ≥18 years old who had a complete record of physical component score and mental component scores in round 2 and round 4 of the survey were included. The primary outcome was HRQOL of diabetes patients as measured by the Medical Outcome Study short-form (SF-12v2TM). Multinomial logistic regression and negative binomial regression were conducted to determine associated factors of HRQOL and HCE, respectively. Overall, 5387 patients were included for analysis. Nearly 60% of patients had unchanged HRQOL after the follow-up, whereas almost 15% to 20% of patients showed improvement in HRQOL. The relative risk of declined mental HRQOL was 1.5 times higher relative to unchanged mental HRQOL in patients who were on sulfonylurea 1.55 [1.1–2.17, p = 0.01] than metformin users. The rate of HCE decreased by a factor of 0.79, [95% CI: 0.63–0.99] in patients with no history of hypertension. Patients on sulfonylurea 1.53 [1.20–1.95, <0.01], insulin 2.00 [1.55–2.70, <0.01], and TZD 1.78 [1.23–2.58, <0.01] had increased risk of HCE compared to patients who were on metformin. In general, antidiabetic medications modestly improved HRQOL in patients with diabetes during the follow-up period. Metformin had a lower rate of HCE as compared to other medications. The selection of anti-diabetes medications should focus on HRQOL in addition to controlling glucose level.
Effects of a Mindfulness and Physical Activity Programme on Anxiety, Depression and Stress Levels in People with Mental Health Problems in a Prison: A Controlled Study
Authors: Gallego Jose , Cangas Adolfo J. , Mañas Israel , Aguilar-Parra Jose M. , Langer Álvaro I. , Navarro Noelia , Lirola Maria-Jesus
Published: February 2023

Recent studies in the general population have shown an inverse relationship between mindfulness and symptoms of anxiety and depression, as well as the benefits of physical activity on these symptoms. These relationships have not yet been studied in a population with severe mental disorder (SMD) in prison, where symptoms of anxiety and depression and impulsive behaviours have a high incidence. A controlled study was developed to assess the benefits of a mindfulness-based protocol whereby elements of Acceptance and Commitment Therapy were evaluated and compared to an adapted sport program. Twenty-two inmates from the “El Acebuche” prison aged between 23 and 58 years old participated in this study, which included a pre-, post-, and follow-up; the majority of participants had SMD and were distributed in both conditions. The DASS-21 was obtained for its evaluation. The results of the Mann–Whitney U test for independent samples indicated a significant reduction in the levels of stress and depression in the mindfulness intervention group compared to the control group in which no significant changes were observed, providing evidence on the effect of this practice in prison contexts.
Post-Treatment Neutrophil and Lymphocyte Counts Predict Progression-Free Survival Following First-Line Chemotherapy in Hodgkin’s Lymphoma
Authors: Tan Grace Fangmin , Goh Siting , Chang Esther Wei Yin , Tan Ya Hwee , Chiang Jianbang , Yang Valerie Shiwen , Poon Eileen Yi Ling , Somasundaram Nagavalli , Bin Harunal Rashid Mohamad Farid , Tao Miriam , Lim Soon Thye , Ong Choon Kiat , Chan Jason Yongsheng
Published: February 2023

Hodgkin’s lymphoma carries an excellent prognosis with modern chemotherapy, but a significant proportion of patients remain refractory to or relapse after first-line treatment. Immunological changes post-treatment, such as chemotherapy-induced neutropenia (CIN) or lymphopenia, have shown prognostic significance in multiple tumor types. Our study aims to investigate the prognostic value of immunologic changes in Hodgkin’s lymphoma by examining the post-treatment lymphocyte count (pALC), neutrophil count (pANC) and the neutrophil-lymphocyte ratio (pNLR). Patients treated for classical Hodgkin’s lymphoma at the National Cancer Centre Singapore using ABVD-based regimens were retrospectively analyzed. An optimal cut-off value for high pANC, low pALC and high pNLR in predicting progression-free survival was determined by receiver operating curve analysis. Survival analysis was performed using the Kaplan–Meier method and multivariable Cox proportional models. Overall OS and PFS were excellent, with a 5-year OS of 99.2% and a 5-year PFS of 88.2%. Poorer PFS was associated with high pANC (HR 2.99, p = 0.0392), low pALC (HR 3.95, p = 0.0038) and high pNLR (p = 0.0078). In conclusion, high pANC, low pALC and high pNLR confer a poorer prognosis for Hodgkin’s lymphoma. Future studies should evaluate the potential of improving treatment outcomes by the adjustment of chemotherapy dose intensity based on post-treatment blood counts.
Comparative Transcriptome Analysis Reveals Potential Genes Conferring Resistance or Susceptibility to Bacterial Canker in Tomato
Authors: Deng Shuozhen , Li Ziyan , Liu Xinyu , Yang Wencai , Wang Yuqing
Published: February 2023

Bacterial canker of tomato is a systemic disease caused by Clavibacter michiganensis (Cm), which poses a grave threat to tomato production worldwide. Towards the identification of genes underlying resistance to Cm infection, the transcriptome of the resistant inbred backcross line IBL2353 carrying the Rcm2.0 locus derived from Solanum habrochaites LA407 and the susceptible Solanum lycopersicum line Ohio88119 was comparatively analyzed after Cm inoculation, and the analysis focused on the genes with different expression patterns between resistant and susceptible lines. Gene ontology (GO) analysis revealed that top terms of differentially expressed genes comprised ubiquitin protein ligases, transcription factors, and receptor kinases. Then we screened out some genes which are potentially associated with the defense response against Cm infection in IBL2353 including the wall-associated receptor kinase-like 20 (WAKL20), and virus-induced gene silencing showed it contributes resistance to Cm infection. In addition to Cm-induced genes related to resistance, the expression of eight homologs from six susceptibility (S) gene families was analyzed. These putative resistance and susceptibility genes are valuable resources for molecular resistance breeding and contribute to the development of new control methods in tomato.
Mechanism of Tolerance to Head-Splitting of Cabbage (Brassica oleracea L. var. capitata L.): A Review of Current Knowledge and Future Directions
Authors: Wang Ying , Li Qiang , Zhang Guoli , Gu Liqiang , Zhao Yuqian , Zhou Lei , Dong Yanqiu , Dong Haiquan , Song Xiaoming
Published: February 2023

Cabbage (Brassica oleracea L. var. capitata L.) is an important cruciferous vegetable, which is rich in dietary fiber, vitamins, beta-carotene and even good for cancer prevention. So, it is widely planted around the world. However, in the production of cabbage, the property of head-splitting not only reduces the appearance quality and commercial value of cabbage but also easily infects the area with head-splitting by germs, resulting in yield reduction, even no yield, and economic losses. For the head-splitting of cabbage, this paper introduced the causes, evaluation methods and indexes, and anatomic properties and reviewed some QTLs that have been obtained. But the cabbage molecular research of head-splitting is still in its infancy compared with other vegetable plants. Head-splitting is greatly affected by water. Although the cultivation and management methods can reduce the head-splitting rate, genetic improvement of head-splitting is still the most economic and efficient way in the long run. Therefore, the changes in the substances regulating cell water potential, the development of cell wall, ductility and toughness, calcium ion-regulated pectinase and cellulase activities, expansin genes, and even the ETH and ABA pathways related to maturation and abscission can provide ideas and directions for future gene mining and mechanism analysis for head-splitting tolerance, and thus accelerate the molecular breeding process.
Collective Prevention of Non-Communicable Diseases in an Ageing Population with Community Care
Authors: Kuppen Regina , de Leede Mirjam , Lindenberg Jolanda , van Bodegom David
Published: February 2023

The Dutch population is rapidly ageing, and a growing number of people are suffering from age-related health problems such as obesity, cardiovascular diseases and diabetes. These diseases can be prevented or delayed by adapting healthy behaviours. However, making long-lasting lifestyle changes has proven to be challenging and most individual-based lifestyle interventions have not been effective on the long-term. Prevention programs focused on lifestyle should involve the physical and social context of individuals, because the (social) environment plays a large role in both conscious and unconscious lifestyle choices. Collective prevention programmes are promising strategies to mobilize the potential of the (social) environment. However, little is known about how such collective prevention programs could work in practice. Together with community care organization Buurtzorg, we have started a 5 year evaluation project to study how collective prevention can be practised in communities. In this paper, we discuss the potential of collective prevention and explain the methods and goals of our study.
IQOS Use and Interest by Sociodemographic and Tobacco Behavior Characteristics among Adults in the US and Israel
Authors: Levine Hagai , Duan Zongshuan , Bar-Zeev Yael , Abroms Lorien C. , Khayat Amal , Tosakoon Sararat , Romm Katelyn F. , Wang Yan , Berg Carla J.
Published: February 2023

Heated tobacco products (HTPs) have expanded globally. IQOS, a global HTP leader, was launched in Israel in 2016 and the US in 2019. To inform tobacco control efforts, it is critical to understand who is likely to use HTPs in different countries with distinct regulatory and marketing contexts. Thus, we conducted a cross-sectional survey among adult (ages 18–45) online panelists in the US (n = 1128) and Israel (n = 1094), oversampling tobacco users, in the fall of 2021, and used multivariable regression to identify correlates of (1) ever using IQOS; (2) past-month vs. former among ever users; and (3) interest in trying IQOS among never users. Among US adults, correlates of ever use included being Asian (aOR = 3.30) or Hispanic (aOR = 2.83) vs. White, and past-month use of cigarettes (aOR = 3.32), e-cigarettes (aOR = 2.67), and other tobacco (aOR = 3.34); in Israel, correlates included being younger (aOR = 0.97), male (aOR = 1.64), and cigarette (aOR = 4.01), e-cigarette (aOR = 1.92) and other tobacco use (aOR = 1.63). Among never users, correlates of greater interest included cigarette and e-cigarette use in the US (β = 0.57, β = 0.90) and Israel (β = 0.88, β = 0.92). IQOS use prevalence was low (US: 3.0%; Israel: 16.2%) but represented in vulnerable subpopulations (younger adults, racial/ethnic minorities).
Effect of Menstrual Cycle Phase on Fuel Oxidation Post HIT in Women Reproductive Age: A Pilot Study
Authors: Frientes Caroline Santana , Marquezi Marcelo Luis , Aparecido Juliana Monique Lino , Cascapera Marcelo Santin , Rogeri Patrícia Soares , Lancha Junior Antônio Herbert
Published: February 2023

Women of childbearing age have variations in substrate oxidation rates that can lead to overweight, type II diabetes, and other conditions that may be associated with metabolic inflexibility and the variations in estrogen concentrations observed during the monthly ovarian cycle. Purpose: This study aimed to verify and compare the influence of eight treadmill high-intensity interval training (HIT) sessions on carbohydrate and lipid oxidation rates (CHOox and LIPox, respectively) and intensities of ventilatory anaerobic thresholds (VATs) of women in different phases of the monthly ovarian cycle. Methods: Eleven irregularly active women performed incremental treadmill exercise testing followed by submaximal work-rate running for 45 min to determine VATs, VO2peak, peak velocity (Vpeak), and substrate oxidation rates, before and after a training period, in different phases of their monthly ovarian cycle (follicular phase group, FL, n = 6; luteal phase group, LT, n = 5). The training period consisted of eight HIT sessions, composed each one of eight sets of 60 s running at 100%Vpeak interspersed by 75 s recovery every 48 h. Results: Our results showed no significant differences in VATs intensities between groups. The comparison between groups showed significant differences in relative energy derived from CHO pre- and post-training of −61.42% and −59.26%, respectively, and LIP pre- and post-training of 27.46% and 34.41%, respectively. The relative energy derived from CHO after the training period was 18.89% and 25.50% higher for FL and LT, respectively; consequently, the relative energy derived from LIPox after the training period was 8,45% and 3.46% lower for FL and LT, respectively. Over the training period, Vpeak was ~13.5 km/h, which produced the relative intensities of ~89%VO2peak e ~93%HRpeak for both groups. Conclusion: The monthly ovarian cycle phases promote significant changes in substrate oxidation rates leading to a decrease in CHOox. High-intensity interval training can minimize the differences observed and constitute an alternative intervention.
Environmental Regulation Effect on Green Total Factor Productivity: Mediating Role of Foreign Direct Investment Quantity and Quality
Authors: Luo Yusen , Lu Zhengnan , Wu Chao , Mensah Claudia Nyarko
Published: February 2023

Green total factor productivity (GTFP) is an excellent index for green development. The objective of this study was to check whether environmental regulation (ER) can affect GTFP through the mediating role of foreign direct investment (FDI) quantity and quality. Using the super-efficiency Epsilon-based measure (EBM) model and a Malmquist–Luenberger (ML) index, China’s GTFP growth was measured during 1998–2018. On this basis, we adopted a Systematic Generalized Method of Moments (SYS-GMM) to analyze the effect of ER on GTFP. The findings show that China’s GTFP declined first and rose again during the sample period. GTFP in the coastland was greater than that in the inland region. ER positively affected China’s GTFP growth. FDI quantity and quality mediated the nexus between ER and GTFP growth in the whole nation. Specifically, this mediation role of FDI quantity and quality was only significant in coastal China. Additionally, financial development can also boost GTFP growth in China. Given the importance of developing a green economy, the government should improve the FDI quality and attract green FDI.
Physical Activity Patterns According to the Type of Physical Education Classes by Sex and Obesity among Korean Adolescents
Authors: Lee Gyuil , Jang Seyong , Kong Sunga
Published: February 2023

This study aimed to compare physical activity patterns according to the type of physical education by sex and body mass index categories among Korean adolescents. We analyzed physical activity using an accelerator in a physical education class among Korean middle school students (1305 boys and 1328 girls). An independent t-test and regression analysis were conducted to compare differences between the obesity groups by sex. As game play time increased, light activity increased in boys in the normal group. Among the girls, sedentary time decreased in the normal, at-risk for obesity, and obese groups. Moderate activity increased in the underweight, normal, at-risk for obesity, and obese groups. Vigorous activity increased in the normal group. As free activity time increased, sedentary time also increased in the normal, at-risk for obesity, and obese groups. Vigorous activity decreased in the normal group. Among the girls, sedentary time increased in the underweight group. Light activity decreased in the underweight and normal groups. A strategy to increase physical activity during physical education class is to increase game play time for girls and decrease free activity time for boys.
Evaluation of a Passive Upper Limb Exoskeleton in Healthcare Workers during a Surgical Instrument Cleaning Task
Authors: Arnoux Bastien , Farr Anaïs , Boccara Vincent , Vignais Nicolas
Published: February 2023

(1) Background: Healthcare workers are highly affected by work-related musculoskeletal disorders, particularly in the lower back, neck and shoulders, as their occupational tasks expose them to biomechanical constraints. One solution to prevent these musculoskeletal disorders may be the use of a passive exoskeleton as it aims to reduce muscle solicitation. However, few studies have been carried out directly in this field to assess the impact of the use of a passive upper limb exoskeleton on this population. (2) Methods: Seven healthcare workers, equipped with electromyographic sensors, performed a tool cleaning task with and without a passive upper limb exoskeleton (Hapo MS, Ergosanté Technologie, France). Six muscles of the upper limbs were analysed, i.e., anterior deltoid, biceps brachii, pectoralis major, latissimus dorsi, triceps brachii and longissimus thoracis. A subjective analysis of the usability of the equipment, the perception of effort and discomfort, was also carried out using the System Usability Scale and the Borg scale. (3) Results: The longissimus thoracis was the most used muscle during this task. We observed a significant decrease in the muscular solicitation of the anterior deltoid and latissimus dorsi when wearing the exoskeleton. Other muscles were not significantly impacted by the device. (4) Conclusions: the passive exoskeleton used in this study allowed the reduction in muscular load on the anterior deltoid and latissimus dorsi without negative effects on other muscles. Other field studies with exoskeletons are now necessary, particularly in hospitals, to increase our knowledge and improve the acceptability of this system for the prevention of musculoskeletal disorders.
Developing a Prediction Model of Demolition-Waste Generation-Rate via Principal Component Analysis
Authors: Cha Gi-Wook , Choi Se-Hyu , Hong Won-Hwa , Park Choon-Wook
Published: February 2023

Construction and demolition waste accounts for a sizable proportion of global waste and is harmful to the environment. Its management is therefore a key challenge in the construction industry. Many researchers have utilized waste generation data for waste management, and more accurate and efficient waste management plans have recently been prepared using artificial intelligence models. Here, we developed a hybrid model to forecast the demolition-waste-generation rate in redevelopment areas in South Korea by combining principal component analysis (PCA) with decision tree, k-nearest neighbors, and linear regression algorithms. Without PCA, the decision tree model exhibited the highest predictive performance (R2 = 0.872) and the k-nearest neighbors (Chebyshev distance) model exhibited the lowest (R2 = 0.627). The hybrid PCA–k-nearest neighbors (Euclidean uniform) model exhibited significantly better predictive performance (R2 = 0.897) than the non-hybrid k-nearest neighbors (Euclidean uniform) model (R2 = 0.664) and the decision tree model. The mean of the observed values, k-nearest neighbors (Euclidean uniform) and PCA–k-nearest neighbors (Euclidean uniform) models were 987.06 (kg·m−2), 993.54 (kg·m−2) and 991.80 (kg·m−2), respectively. Based on these findings, we propose the k-nearest neighbors (Euclidean uniform) model using PCA as a machine-learning model for demolition-waste-generation rate predictions.
The Effects of Routinization on Radical and Incremental Creativity: The Mediating Role of Mental Workloads
Authors: Chae Heesun , Park Jisung
Published: February 2023

An important question within the creativity literature is whether routinization inhibits individuals’ creative performance. Scholars have concentrated on complex and demanding jobs that promote creativity while ignoring the potential effects of routinized activities on creativity. Moreover, little is known about the impact of routinization on creativity, and the few studies investigating this matter have reported inconclusive and inconsistent results. This study investigates the mixed impacts of routinization on creativity by examining whether routinization has a direct impact on two dimensions of creativity or an indirect impact through the mediating role of mental workloads, such as mental effort load, time load, and psychological stress load. Based on multisource and time-lagged data from 213 employee–supervisor dyads, we found a positive direct effect of routinization on incremental creativity. In addition, routinization had both an indirect effect on radical creativity via time load and on incremental creativity via mental effort load. Implications for theory and practice are discussed.
Estimated Dietary Fluoride Intake by 24-Month-Olds from Chocolate Bars, Cookies, Infant Cereals, and Chocolate Drinks in Brazil
Authors: Araujo Tamara Teodoro , Moraes Samanta Mascarenhas , Carvalho Thamyris de Souza , Grizzo Larissa Tercilia , Buzalaf Marilia Afonso Rabelo
Published: February 2023

The use of fluoride (F) in the prevention of dental caries is established. However, a high amount of F intake during tooth development can cause dental fluorosis The aim of this study was to analyze variations in F concentrations in chocolate bars (CB), chocolate cookies (CC), infant cereals (IC), and chocolate milk drinks (CD) to determine the daily intake of F from different sources by children at the age of risk for developing dental fluorosis. Distinct brands of CB, CC, IC, and CD were analyzed. Fluoride was separated by hexamethyldisiloxane-facilitated diffusion. Analysis was made in triplicate with an F ion-specific electrode. F ingestion (mg/kg body weight) was evaluated with the suggested consumption (0.05–0.07 mg/kg/day) for children aged 24 months (12 kg). The concentrations for all the analyzed products ranged from 0.025 to 1.827 µg/g F. The mean (range) F concentrations were CB= 0.210 ± 0.205 µg/g (0.073–0.698, n = 8), CC = 0.366 ± 0.416 µg/g (0.320–1.827, n = 9), IC = 0.422 ± 0.395 µg/g (0.073–1.061, n = 5), and CD = 0.169 ± 0.170 µg/mL (0.025–0.443, n = 12). The products that had the highest concentration in the categories CB, CC, IC, and CD, respectively, were Nescau-Ball (0.698 µg/g), Passatempo (1.827 µg/g), Milnutri (1.061 µg/g), and Toddynho (0.443 µg/mL). The consumption of only one unit of Toddynho (CD) is equivalent to more than 11% of the maximum suggested daily intake for a 24-month-old child (0.07 mg/kg body weight). When one product from each category is consumed together only once a day, this consumption is equivalent to approximately 24% of the suggested daily intake of fluoride for a 24-month-old child. The presence of high levels of fluoride in certain products suggests that they play a significant role in overall fluoride intake. It is crucial to closely monitor the fluoride content of food and drinks that are consumed by children who are at risk for dental fluorosis, and for product labels to clearly display the fluoride concentrations.
Is Early Initiation of Maternal Lactation a Significant Determinant for Continuing Exclusive Breastfeeding up to 6 Months?
Authors: Mena-Tudela Desirée , Soriano-Vidal Francisco Javier , Vila-Candel Rafael , Quesada José Antonio , Martínez-Porcar Cristina , Martin-Moreno Jose M.
Published: February 2023

Background: The World Health Organization (WHO) recommends early initiation of breastfeeding (EIBF) within the first hour after birth. However, certain perinatal factors, namely caesarean section, may prevent this goal from being achieved. The aim of our study was to examine the relationship between EIBF (maternal lactation in the first hours and degree of latching before hospital discharge) and the maintenance of exclusive breastfeeding (MBF) up to the recommended 6 months of age (as advocated by the WHO). Methods: This observational, retrospective cohort study included a random sample of all births between 2018 and 2019, characterising the moment of breastfeeding initiation after birth and the infant’s level of breast latch (measured by LATCH assessment tool) prior to hospital discharge. Data were collected from electronic medical records and from follow-up health checks of infants up to 6 months postpartum. Results: We included 342 women and their newborns. EIBF occurred most often after vaginal (p < 0.001) and spontaneous births with spontaneous amniorrhexis (p = 0.002). LATCH score <9 points was associated with a 1.4-fold relative risk of abandoning MBF (95%CI: 1.2–1.7) compared with a score of 9–10 points. Conclusions: Although we were unable to find a significant association between EIBF in the first 2 h after birth and MBF at 6 months postpartum, low LATCH scores prior to discharge were associated with low MBF, indicating the importance of reinforcing the education and preparation efforts of mothers in the first days after delivery, prior to the establishment of an infant feeding routine upon returning home.
Aneurysmal Subarachnoid Hemorrhage and Clinical Decision-Making: A Qualitative Pilot Study Exploring Perspectives of Those Directly Affected, Their Next of Kin, and Treating Clinicians
Authors: Göcking Beatrix , Biller-Andorno Nikola , Brandi Giovanna , Gloeckler Sophie , Glässel Andrea
Published: February 2023

Background: Exploring the experience and impact of aneurysmal subarachnoid hemorrhage (aSAH) from three perspectives, that of those directly affected (AFs), their next of kin (NoK), and treating clinicians, is a way to support and empower others to make informed medical decisions. Methods: In a Swiss neurosurgical intensive care unit (ICU), eleven semi-structured interviews were conducted as part of a Database of Individual Patient Experiences (DIPEx) pilot project and thematically analyzed. Interviews were held with two clinicians, five people experiencing aSAH, and four NoK 14–21 months after the bleeding event. Results: Qualitative analysis revealed five main themes from the perspective of clinicians: emergency care, diagnosis and treatment, outcomes, everyday life in the ICU, and decision-making; seven main themes were identified for AFs and NoK: the experience of the aSAH, diagnosis and treatment, outcomes, impact on loved ones, identity, faith, religion and spirituality, and decision-making. Perspectives on decision-making were compared, and, whereas clinicians tended to focus their attention on determining treatment, AFs and NoK valued participation in shared decision-making processes. Conclusions: Overall, aSAH was perceived as a life-threatening event with various challenges depending on severity. The results suggest the need for tools that aid decision-making and better prepare AFs and NoK using accessible means and at an early stage.
Psychological Adjustment Profiles of LGBTQ+ Young Adults Residing with Their Parents during the COVID-19 Pandemic: An International Study
Authors: Vázquez Inês , Gato Jorge , Coimbra Susana , Tasker Fiona , Barrientos Jaime , Miscioscia Marina , Cerqueira-Santos Elder , Malmquist Anna , Seabra Daniel , Leal Daniela , Houghton Marie , Poli Mikael , Gubello Alessio , Ramos Mozer de Miranda , Guzmán-González Mónica , Urzúa Alfonzo , Ulloa Francisco , Wurm Matilda
Published: February 2023

The COVID-19 pandemic has been associated with poor mental health symptoms, particularly among vulnerable populations such as LGBTQ+ individuals. In the present study, we aimed to (i) identify different psychological adjustment profiles among LGBTQ+ young adults during the COVID-19 pandemic and compare LGBTQ+ young adults in relation to (ii) sociodemographic characteristics and COVID-19-related experiences and (iii) the internal and external protective resources associated with each adjustment profile. An online questionnaire was administered to 1699 LGBTQ+ young adults from six countries (Brazil, Chile, Italy, Portugal, Sweden, and the UK). A cluster analysis was conducted, and four profiles of psychological adjustment were identified: unchallenged, resilient, distressed, and at-risk. The at-risk cluster scored lowest in social support (particularly from family). The profiles of participants who experienced the highest levels of pandemic adversity (at-risk and resilient) comprised mostly South American participants, those under lockdown at the time of survey completion, those who self-identified as transgender and non-binary, and those with a plurisexual sexual orientation. Interventions should consider strategies to help young adults maintain support systems and reinforce the value of positive family relationships. Specific groups within the LGBTQ+ community that seem to be in a particularly vulnerable situation may need additional tailored support.
Multi-Objective Optimization Applied to the Design of Sustainable Pedestrian Bridges
Authors: Tres Junior Fernando Luiz , Yepes Víctor , Medeiros Guilherme Fleith de , Kripka Moacir
Published: February 2023

The demand for more sustainable structures has been shown as a growing tendency, and engineers can use optimization techniques to aid in the design and sizing stage, achieving solutions that minimize its cost and environmental and social impacts. In pedestrian bridges, which are subjected to human-induced vibrations, it is also important to ensure the users’ comfort, besides the security verifications. In this context, the objective of this paper is to perform a multi-objective optimization of a steel-concrete composite pedestrian bridge, minimizing cost, carbon dioxide emissions, and vertical acceleration caused by human walking. For this, the Multi-Objective Harmony Search (MOHS) was applied to obtain non-dominated solutions and compose a Pareto Front. Two scenarios were considered with different unit emissions obtained from a life cycle assessment in the literature. Results show that by increasing 15% the structure cost, the vertical acceleration is reduced from 2.5 to 1.0 m/s2. For both scenarios, the optimal ratio for the web height and total span (Le) lies between Le/20 and Le/16. The web height, the concrete strength, and the slab thickness were the design variables with more influence on the value of the vertical acceleration. The Pareto-optimal solutions were considerably sensitive to the parameters varied in each scenario, changing concrete consumption and dimensions of the welded steel I-beam, evidencing the importance of carrying out a sensitivity analysis in optimization problems.
Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers
Authors: Bracci Massimo , Zingaretti Laura , Martelli Margherita , Lazzarini Raffaella , Salvio Gianmaria , Amati Monica , Milinkovic Marijana , Ulissi Alfio , Medori Anna , Vitale Ermanno , Ledda Caterina , Santarelli Lory
Published: February 2023

Steroid hormone levels are closely related to the endogenous circadian rhythm induced by sleep–wake and dark–light cycles. Shift work that disrupts the circadian rhythm may influence the levels of steroid hormones. The association between shift work and alterations in female sex steroid hormone levels has been studied, but little is known about testosterone and its precursor pregnenolone levels in male shift workers. The present study investigated serum pregnenolone and testosterone levels in a group of shift and daytime male workers. All participants were sampled at the beginning of the morning shift. Lower levels of serum pregnenolone and total testosterone were found in the shift workers compared to the daytime workers. Variations in pregnenolone levels may have consequences for well-being, and they might produce consequences for the levels of hormones downstream of the steroid hormone cascade, such as testosterone. The low levels of testosterone found in shift workers demonstrate the perturbative effect of shift work on testosterone serum levels, which may be independent and/or related to pregnenolone synthesis.
Apple Leave Disease Detection Using Collaborative ML/DL and Artificial Intelligence Methods: Scientometric Analysis
Authors: Bonkra Anupam , Bhatt Pramod Kumar , Rosak-Szyrocka Joanna , Muduli Kamalakanta , Pilař Ladislav , Kaur Amandeep , Chahal Nidhi , Rana Arun Kumar
Published: February 2023

Infection in apple leaves is typically brought on by unanticipated weather conditions such as rain, hailstorms, draughts, and fog. As a direct consequence of this, the farmers suffer a significant loss of productivity. It is essential to be able to identify apple leaf diseases in advance in order to prevent the occurrence of this disease and minimise losses to productivity caused by it. The research offers a bibliometric analysis of the effectiveness of artificial intelligence in diagnosing diseases affecting apple leaves. The study provides a bibliometric evaluation of apple leaf disease detection using artificial intelligence. Through an analysis of broad current developments, publication and citation structures, ownership and cooperation patterns, bibliographic coupling, productivity patterns, and other characteristics, this scientometric study seeks to discover apple diseases. Nevertheless, numerous exploratory, conceptual, and empirical studies have concentrated on the identification of apple illnesses. However, given that disease detection is not confined to a single field of study, there have been very few attempts to create an extensive science map of transdisciplinary studies. In bibliometric assessments, it is important to take into account the growing amount of research on this subject. The study synthesises knowledge structures to determine the trend in the research topic. A scientometric analysis was performed on a sample of 214 documents in the subject of identifying apple leaf disease using a scientific search technique on the Scopus database for the years 2011–2022. In order to conduct the study, the Bibliometrix suite’s VOSviewer and the web-based Biblioshiny software were also utilised. Important journals, authors, nations, articles, and subjects were chosen using the automated workflow of the software. Furthermore, citation and co-citation checks were performed along with social network analysis. In addition to the intellectual and social organisation of the meadow, this investigation reveals the conceptual structure of the area. It contributes to the body of literature by giving academics and practitioners a strong conceptual framework on which to base their search for solutions and by making perceptive recommendations for potential future research areas.
Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis
Authors: García-Valdivieso Inmaculada , Yáñez-Araque Benito , Moncunill-Martínez Eva , Bocos-Reglero M. Jesús , Gómez-Cantarino Sagrario
Published: February 2023

In neonatology, neonates have traditionally been considered incapable of feeling pain, due to the immaturity of their nervous system. Currently, there is sufficient information on the perception of pain in neonates; however, this treatment at this crucial stage for development requires a better approach. For this reason, the aim of this study was to analyse the efficacy of non-pharmacological analgesia interventions during heel prick, and to assess their effects on heart rate (HR), premature infant pain profile (PIPP) and O2 saturation. A systematic review and meta-analysis was performed following the guidelines of the preferred reporting items for systematic reviews and meta-analyses (PRISMA), and the Cochrane collaboration handbook. The databases PubMed, Cochrane Library, Web of Science, Scopus, CINAHL and Science Direct were searched until the end of January 2022. The DerSimonian and Laird methods were used to estimate the effect size with a 95% confidence interval (CI95%). Effect size estimates were 0.05 (95% CI: −0.19, 0.29) for HR, −0.02 (95% CI: −0.24, 0.21) for PIPP scale, and −0.12 (95% CI: −0.29, 0.05) for O2 saturation. The non-pharmacological interventions analysed (breastfeeding, kangaroo-mother care method, oral sucrose and non-nutritive sucking) were not statistically significant in reducing neonatal pain, but did influence the decrease in pain score and a faster stabilisation of vital signs.
Diffusion Behavior of VOC Molecules in Polyvinyl Chloride Investigated by Molecular Dynamics Simulation
Authors: Mao Yun-Feng , Long Shun-Nan , Li Zhuo , Tao Wen-Quan
Published: February 2023

Due to the threats posed by many volatile organic compounds (VOCs) to human health in indoor spaces via air, the mass transfer characteristics of VOCs are of critical importance to the study of their mechanism and control. As a significant part of the mass transfer process, diffusion widely exists in emissions from floors (e.g., PVC floors) and in sorption in porous materials. Molecular simulation studies by can provide unparalleled insights into the molecular mechanisms of VOCs. We construct the detailed atomistic structures of PVC blend membranes to investigate the diffusion behavior of VOC molecules (n-hexane) in PVC by molecular dynamics (MD). The variation in the diffusion coefficient of n-hexane in PVC with respect to temperature is in line with Arrhenius’ law. The effect of temperature on the diffusion mechanism was investigated from the perspectives of free volume, cavity distribution and polymer chain mobility. It was found that the relationships between the diffusion coefficients of n-hexane in the polymer and the inverse fractional free volume are exponential and agree well with the free volume theory. Hopefully, this study will offer quantitative insights into the mass transport phenomena of VOCs within polymeric materials.
A Look at the Interconnection of Dimensions of Knowledge in Physical Education Teacher Training in Chile
Authors: Peña-Troncoso Sebastián , Toro-Arévalo Sergio , Vega-Ramírez Javier , Gallardo-Fuentes Francisco , Pazos-Couto José María
Published: February 2023

The massive fragmentation of knowledge that exists in the current field of physical education enables us to research pedagogical and disciplinary aspects in the educational processes of teachers in training, as this has significant implications for future educational practices. This study proposes to assess the dimensions of knowledge (conceptual, procedural and attitudinal) that stem from the learnings that emerge in physical education teacher training in terms of the disciplinary standards proposed by the Chilean Education Ministry for the Preservice Teacher Education. The study methodology was descriptive and inferential, and the cohort was cross-sectional. A total of 750 fourth- and fifth-year students in training from 13 Chilean universities participated. Of these, 619 subjects were considered: 54.6% (338) men and 45.4% (281) women between the ages of 21 and 25. The questionnaire used for data collection was the “Questionnaire on Conceptual, Procedural and Attitudinal Learning in Preservice Teacher Education in Physical Education” (CACPA-FIDEF), prepared as part of Fondecyt project No. 11190537. The main results indicate that there are no statistically significant differences in the three dimensions in terms of students’ sex and type of schooling, with p values > 0.05. In conclusion, the study observed a weak conceptual management of the discipline in future teachers, revealing once again the need to seek out didactic alternatives that enable teachers in training to understand the importance of the conceptual dimension in their learning and teaching processes.