bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety Evaluation of Heavy Metal Contamination and Pesticide Residues in Coix Seeds in Guizhou Province, China
Authors: Yu Jiaxing , Wang Xiangui , Yao Xiaolong , Wu Xiaomao
Published: August 2022

The coix seed is a medicinal and edible plant with rich nutritional and medicinal values. With the expansion of the coix seed consumption market, the problem of coix seed safety has attracted attention worldwide. The aims of this work were to evaluate the contamination of mercury (Hg), lead (Pb), cadmium (Cd), arsenic (As), chromium (Cr) and 116 pesticides in coix seeds collected from 12 main producing regions of coix seeds in the Guizhou Province of China and to analyze the major contributors of heavy metal and pesticide contamination in coix seed. The results show that the average contents of Pb, Cd, As and Cr in the 123 coix seed samples were 0.0069, 0.0021, 0.0138 and 0.1107 mg/kg, respectively, while Hg was not detected in all coix seed samples. Among the five heavy metals detected, only the Cr contents of three samples were found to be higher than the contaminant limit of Chinese standard GB2762-2017 (CSGB). A total of 13 pesticides were detected in 29 samples from seven main production regions of coix seeds, accounting for 23.6% of all the samples. The detection rates of chlorpyrifos were the highest (8.13%), followed by fenpropathrin (4.06%), bifenthrin (2.43%) and phoxim (1.62%), while the detection rates of the remaining pesticides were below 1%. Moreover, the residual risk score of dichlorvos was the highest of all the pesticides detected. The pollution index and risk assessment of heavy metals and pesticide residues indicates that coix seeds were at safe levels for consumption. In the production process of coix seeds, the local government should control the soil in areas heavily polluted by heavy metals and strengthen the monitoring and guidance on the scientific and rational use of pesticides.
Mayonnaise Enriched with Flaxseed Oil: Omega-3 Fatty Acids Content, Sensory Quality and Stability during the Storage
Authors: El-Waseif Mohammed , Saed Badr , Fahmy Hany , Sabry Ahmed , Shaaban Hamdy , Abdelgawad Mohamed , Amin Ali , Farouk Amr
Published: August 2022

This study aimed to produce healthy mayonnaise with a protective effect against cardiovascular diseases, containing omega-3 fatty acids (FA), using flaxseed oil (FXO), which includes a high percentage of alpha-linolenic acid (ALA, C18:3n-3). The mayonnaise was prepared by replacing soybean oil with FXO at 20, 30, and 40% levels. The effect on the organoleptic, physical, and chemical quality was studied compared to a control, prepared only with soybean oil (70%). The oxidative and microbial stability during 12 weeks of storage at 25 and 7 °C was also evaluated. The results showed that the use of FXO in mayonnaise (20, 30, and 40%) led to an increase in TUFA (from 79.37 (control) to 82.48, 85.49, and 87.66%, respectively), particularly in PUFAn-3, due to the rise of ALA (from 6.5 to 18.38, 24.02 and 37.87%, respectively) and a decrease in TSFA (from 20.63 to 17.52, 14.51 and 12.34%, respectively). The panelists did not perceive significant differences in the sensory characteristics of the “new” mayonnaise. A decrease in the oxidation rates of the “new” mayonnaise during the storage period was observed. A significant effect on microbial growth was not reported, although the permissible limits were not exceeded after 12 weeks of storage, even at 25 °C.
Molecular Link in Flavonoid and Amino Acid Biosynthesis Contributes to the Flavor of Changqing Tea in Different Seasons
Authors: Ma Qingping , Qin Mengyao , Song Laichao , Sun Haiwei , Zhang Hong , Wu Huanhuan , Ren Zhihong , Liu Hui , Duan Gang , Wang Yu , Ding Zhaotang
Published: August 2022

The present study was aimed to elucidate the flavor formation mechanism of Changqing tea. High-performance liquid chromatography (HPLC) analysis showed that the total catechins of Changqing tea was 65–160 mg/g, with 16–34 mg/g non-galloyated catechins and 49–126 mg/g galloylated catechins. Tea polyphenols and free amino acids account for 286–312 mg/g and 35–89 mg/g, respectively. Transcriptome of Changqing tea during different seasons revealed 316, 130 and 12 DEGs in comparisons of spring vs. autumn, spring vs. summer, and summer vs. autumn, respectively. Compared to spring, the genes involved in flavonoid biosynthesis and bitter imparted amino acids were up-regulated in summer and autumn. Metabolome analysis was conducted by using HPLC-MS; the result indicated that umami and kokumi contributing amino acids were decreased in summer and autumn compared with spring. It could be concluded that the coordination of flavonoid biosynthesis and amino acids biosynthesis resulted in the special flavor of Changqing tea.
Efficient Removal of Polyvalent Metal Ions (Eu(III) and Th(IV)) from Aqueous Solutions by Polyurea-Crosslinked Alginate Aerogels
Authors: Georgiou Efthalia , Pashalidis Ioannis , Raptopoulos Grigorios , Paraskevopoulou Patrina
Published: August 2022

The removal of polyvalent metal ions Eu(III) and Th(IV) from aqueous solutions using polyurea-crosslinked calcium alginate (X-alginate) aerogels has been investigated by batch-type experiments under ambient conditions and pH 3. The material presents relatively high sorption capacity for Eu(III) (550 g kg−1) and Th(IV) (211 g kg−1). The lower sorption capacity for Th(IV) compared to Eu(III) is attributed to the net charge of the dominant species in solution under the given experimental conditions, which is Eu3+ for Eu(III), and Th(OH)22+ and Th(OH)3+ for Th(IV). Generally, the sorption is an endothermic and entropy-driven process, and it follows the Langmuir isotherm model. According to the FTIR spectra, sorption occurs via formation of inner-sphere complexes between the surface functional groups and the f-metal cationic species. The presence of europium and thorium in the adsorbent material was confirmed and quantified with EDS analysis. To the best of our knowledge, this is the first report of an aerogel material used as an adsorbent for Eu(III). Compared to other materials used for the sorption of the specific ions, which are mostly carbon-based, X-alginate aerogels show by far the highest sorption capacity. Regarding Th(IV) uptake, X-alginate aerogels show the highest capacity per volume (27.9 g L−1) among the aerogels reported in the literature. Both Eu(III) and Th(IV) could be recovered from the beads by 65% and 70%, respectively. Furthermore, Th(VI) could also be quantitatively removed from wastewater, while Eu(III) could be removed by 20%. The above, along with their stability in aqueous environments, make X-alginate aerogels attractive candidates for water treatment and metal recovery applications.
Managing the Aging Present and Perceiving the Aging Futures: (In)Formal Systems of Care in (Pre-)Pandemic Croatia
Authors: Rubić Tihana , Vukušić Ana-Marija
Published: August 2022

The article is an ethnographic account of recent and contemporary narratives and practices of care and aging in Croatia in the pre-pandemic and COVID-19 pandemic period, within the framework of formal, informal, and “hybrid” systems of care. Its theoretical basis lies in the fields of the anthropology of family, and the anthropology of aging and care, as well as in the concepts of dignity and the conceptions of futures. The ethnographic data were gathered from 2018–2021, in four locations/regions, both in rural and urban settings. The aim of the paper is to initiate a discussion about the qualitative, socio-cultural aspects of aging and everyday life of the elderly, of its transformations and continuities, both in the spatial and temporal dimension, in urban and rural contexts, in crisis, and in “times of peace”.
Forensic Analysis and Genetic Structure Construction of Chinese Chongming Island Han Based on Y Chromosome STRs and SNPs
Authors: Zhang Xiao , Tang Zhen , Wang Bin , Zhou Xindao , Zhou Limin , Zhang Gongying , Tian Junzhe , Zhao Yiqi , Yao Zhiqing , Tian Lu , Zhang Suhua , Xia Hao , Jin Li , Li Chengtao , Li Shilin
Published: August 2022

Y-chromosome short tandem repeat (Y-STR) and Y-chromosome single nucleotide polymorphism (Y-SNP) are genetic markers on the male Y chromosome for individual identification, forensic applications, and paternal genetic history analysis. In this study we successfully genotyped 38 Y-STR loci and 24 Y-SNP loci of Pudong Han (n = 689) and Chongming Han (n = 530) in Shanghai. The haplotype diversity of the Y filer platinum genotyping system was the highest in the Han population in the Pudong area of Shanghai (0.99996) and Chongming Island (0.99997). The proportion of unique haplotypes was 97.10% (Pudong) and 98.49% (Chongming), respectively. The multidimensional scaling analysis and phylogenetic analysis were performed according to the genetic distance Rst, which was calculated based on the Y-STR gene frequency data. Moreover, we made a comparison on the frequency distribution analysis and principal component analysis of haplogroups in both populations. As a result, Shanghai Pudong Han, Chongming Island Han, and Jiangsu Han were determined to have a strong genetic affinity. The haplogroup distribution characteristics of the Pudong Han and Chongming Han populations were similar to those of the southern Han population. The results of haplotype network analysis showed that Jiangsu Wujiang Han and Jiangsu Changshu Han had more paternal genetic contributions to the formation of Shanghai Pudong Han and Chongming Island Han. Through the joint analysis of SNPs and STRs, this study deeply analyzed the paternal genetic structure of the Pudong Han and Chongming Han populations. The addition of Y-SNP haplogroups to forensic applications can provide information for pedigree investigation.
TIRAP Rs8177376, Rs611953, Rs3802814, and Rs8177374 Polymorphisms and Their Association with Cervical Cancer Phenotype and Prognosis
Authors: Bekampytė Justina , Savukaitytė Aistė , Bartnykaitė Agnė , Ugenskienė Rasa , Žilienė Eglė , Inčiūra Arturas , Juozaitytė Elona
Published: August 2022

Cervical cancer is one of the most common cancers in women worldwide, which is typically caused by human papillomavirus (HPV). Usually, the toll-like receptor (TLR) signaling pathways eliminate the virus from the organism, but in some cases, persistent infection may develop. Unfortunately, the mechanism of immune tolerance is still unclear. Therefore, this study aimed to analyze TIRAP rs8177376, rs611953, rs3802814, and rs8177374 polymorphisms and to identify their impact on cervical cancer phenotype and prognosis. This study included 172 cervical cancer patients. Genotyping was performed using the PCR-RFLP assay. Univariate and multivariate logistic regression and Cox′s regression models were applied for statistical analysis. The results revealed that older age at the time of diagnosis was statistically linked with the rs8177376 T allele (OR = 2.901, 95% Cl 1.750–4.808, p = 0.000) and the rs611953 G allele (OR = 3.258, 95% Cl 1.917–5.536, p = 0.000). Moreover, the T allele of rs8177376 (OR = 0.424, 95% Cl 0.220–0.816, p = 0.010) was found to be statistically associated with the lower tumor grade. Thus, TIRAP polymorphisms might be employed in the future as potential biomarkers for determining the phenotype and prognosis of cervical cancer.
Investigation of Genetic Causes in Patients with Congenital Heart Disease in Qatar: Findings from the Sidra Cardiac Registry
Authors: Okashah Sarah , Vasudeva Dhanya , El Jerbi Aya , Khodjet-El-khil Houssein , Al-Shafai Mashael , Syed Najeeb , Kambouris Marios , Udassi Sharda , Saraiva Luis R. , Al-Saloos Hesham , Udassi Jai , Al-Shafai Kholoud N.
Published: August 2022

Congenital heart disease (CHD) is one of the most common forms of birth defects worldwide, with a prevalence of 1–2% in newborns. CHD is a multifactorial disease partially caused by genetic defects, including chromosomal abnormalities and single gene mutations. Here, we describe the Sidra Cardiac Registry, which includes 52 families and a total of 178 individuals, and investigate the genetic etiology of CHD in Qatar. We reviewed the results of genetic tests conducted in patients as part of their clinical evaluation, including chromosomal testing. We also performed whole exome sequencing (WES) to identify potential causative variants. Sixteen patients with CHD had chromosomal abnormalities that explained their complex CHD phenotype, including six patients with trisomy 21. Moreover, using exome analysis, we identified potential CHD variants in 24 patients, revealing 65 potential variants in 56 genes. Four variants were classified as pathogenic/likely pathogenic based on the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP) classification; these variants were detected in four patients. This study sheds light on several potential genetic variants contributing to the development of CHD. Additional functional studies are needed to better understand the role of the identified variants in the pathogenesis of CHD.
Mosaic Evolution of Molecular Pathways for Sex Pheromone Communication in a Butterfly
Authors: Nieberding Caroline M. , Beldade Patrícia , Baumlé Véronique , San Martin Gilles , Arun Alok , Lognay Georges , Montagné Nicolas , Bastin-Héline Lucie , Jacquin-Joly Emmanuelle , Noirot Céline , Klopp Christophe , Visser Bertanne
Published: August 2022

Unraveling the origin of molecular pathways underlying the evolution of adaptive traits is essential for understanding how new lineages emerge, including the relative contribution of conserved ancestral traits and newly evolved derived traits. Here, we investigated the evolutionary divergence of sex pheromone communication from moths (mostly nocturnal) to butterflies (mostly diurnal) that occurred ~119 million years ago. In moths, it is the females that typically emit pheromones to attract male mates, but in butterflies males emit pheromones that are used by females for mate choice. The molecular bases of sex pheromone communication are well understood in moths, but they have remained relatively unexplored in butterflies. We used a combination of transcriptomics, real time qPCR, and phylogenetics to identify genes involved in the different steps (i.e., production, regulation, and reception) of sex pheromone communication of the butterfly Bicyclus anynana. Our results show that the biosynthesis and reception of sex pheromones relies both on moth-specific gene families (reductases) and on more ancestral insect gene families (desaturases, olfactory receptors, odorant binding proteins). Interestingly, B. anynana appears to use what was believed to be the moth-specific neuropeptide Pheromone Biosynthesis Activating Neuropeptide (PBAN) for regulating sex pheromone production. Altogether, our results suggest that a mosaic pattern best explains how sex pheromone communication evolved in butterflies, with some molecular components derived from moths, and others conserved from more ancient insect ancestors. This is the first large-scale investigation of the genetic pathways underlying sex pheromone communication in a butterfly.
New Insights into the Regulatory Role of Ferroptosis in Ankylosing Spondylitis via Consensus Clustering of Ferroptosis-Related Genes and Weighted Gene Co-Expression Network Analysis
Authors: Rong Tianhua , Jia Ningyi , Wu Bingxuan , Sang Dacheng , Liu Baoge
Published: August 2022

Background: The pathogenesis of ankylosing spondylitis (AS) remains undetermined. Ferroptosis is a newly discovered form of regulated cell death involved in multiple autoimmune diseases. Currently, there are no reports on the connection between ferroptosis and AS. Methods: AS samples from the Gene Expression Omnibus were divided into two subgroups using consensus clustering of ferroptosis-related genes (FRGs). Weighted gene co-expression network analysis (WGCNA) of the intergroup differentially expressed genes (DEGs) and protein–protein interaction (PPI) analysis of the key module were used to screen out hub genes. A multifactor regulatory network was then constructed based on hub genes. Results: The 52 AS patients in dataset GSE73754 were divided into cluster 1 (n = 24) and cluster 2 (n = 28). DEGs were mainly enriched in pathways related to mitochondria, ubiquitin, and neurodegeneration. Candidate hub genes, screened by PPI and WGCNA, were intersected. Subsequently, 12 overlapping genes were identified as definitive hub genes. A multifactor interaction network with 45 nodes and 150 edges was generated, comprising the 12 hub genes and 32 non-coding RNAs. Conclusions: AS can be divided into two subtypes according to FRG expression. Ferroptosis might play a regulatory role in AS. Tailoring treatment according to the ferroptosis status of AS patients can be a promising direction.
Complete Mitochondrial Genome of Two Ectoparasitic Capsalids (Platyhelminthes: Monogenea: Monopisthocotylea): Gene Content, Composition, and Rearrangement
Authors: Yang Changping , Shan Binbin , Liu Yan , Wang Liangming , Wu Qiaer , Luo Zhengli , Sun Dianrong
Published: August 2022

The capsalid monogeneans are important pathogens that generally infect marine fishes and have a substantial impact on fish welfare in aquaculture systems worldwide. However, the current mitogenome information on capsalids has received little attention, limiting the understanding of their evolution and phylogenetic relationships with other monogeneans. This paper reports the complete mitochondrial genomes of Capsala katsuwoni and Capsala martinieri for the first time, which we obtained using a next-generation sequencing method. The mitogenomes of C. katsuwoni and C. martinieri are 13,265 and 13,984 bp in length, respectively. Both species contain the typical 12 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a control region. The genome compositions show a moderate A+T bias (66.5% and 63.9% for C. katsuwoni and C. martinieri, respectively) and exhibit a negative AT skew but a positive GC skew in both species. One gene block rearrangement was found in C. katsuwoni in comparison with other capsalid species. Instead of being basal to the Gyrodactylidea and Dactylogyridea or being clustered with Dactylogyridea, all species of Capsalidea are grouped into a monophyletic clade. Our results clarify the gene rearrangement process and evolutionary status of Capsalidae and lay a foundation for further phylogenetic studies of monogeneans.
Hydrothermal Numerical Simulation of Injection Operations at United Downs, Cornwall, UK
Authors: Mahmoodpour Saeed , Singh Mrityunjay , Obaje Christian , Tangirala Sri Kalyan , Reinecker John , Bär Kristian , Sass Ingo
Published: August 2022

The United Downs Deep Geothermal Project (UDDGP) is designed to utilize a presumably permeable steep dipping fault damage zone (constituting the hydrothermal reservoir in a very low permeability granitic host rock) for fluid circulation and heat extraction between an injection well at 2.2 km depth (UD−2) and a production well at 5 km depth (UD−1). Soft hydraulic stimulation was performed to increase the permeability of the reservoir. Numerical simulations are performed to analyze the hydraulic stimulation results and evaluate the increase in permeability of the reservoir. Experimental and field data are used to characterize the initial reservoir static model. The reservoir is highly fractured, and two distinct fracture networks constitute the equivalent porous matrix and fault zone, respectively. Based on experimental and field data, stochastic discrete fracture networks (DFN) are developed to mimic the reservoir permeability behavior. Due to the large number of fractures involved in the stochastic model, equivalent permeability fields are calculated to create a model which is computationally feasible. Hydraulic test and stimulation data from UD−1 are used to modify the equivalent permeability field based on the observed difference between the real fractured reservoir and the stochastic DFN model. Additional hydraulic test and stimulation data from UD−2 are used to validate this modified permeability. Results reveal that the equivalent permeability field model derived from observations made in UD−1 is a good representation of the actual overall reservoir permeability, and it is useful for future studies. The numerical simulation results show the amount of permeability changes due to the soft hydraulic stimulation operation. Based on the validated permeability field, different flow rate scenarios of the petrothermal doublet and their respective pressure evolution are examined. Higher flow rates have a strong impact on the pressure evolution. Simulations are performed in the acidized enhanced permeability region to make a connection between the ongoing laboratory works on the acid injection and field response to the possible acidizing stimulation.
Updated Understanding of the Ripley Landslide Kinematics Using Satellite InSAR
Authors: Soltanieh Amir , Macciotta Renato
Published: August 2022

The Thompson River valley hosts 14 landslides along a 10 km section, which threaten the two major railroads connecting the Port of Vancouver and the interior provinces in Canada. The Ripley landslide is one of the active landslides in this section of the valley. Previous research at this site included an analysis of landslide deformations using satellite radar interferometry focusing on deformations measured in the line of sight between the satellite and the slopes, and average downslope displacement (deformations projected in the average downslope direction). Since then, further stratigraphic interpretation has provided an enhanced understanding of the Ripley landslide. In this update, the new stratigraphic interpretation is supplemented with satellite InSAR data from May 2015 to May 2017 to enhance the current understanding of the landslide kinematics. The results indicate that the Ripley landslide has been moving at a rate between 2 and 82 mm per year, corresponding to a very slow to slow landslide. It is also observed that the movements tend to be near-horizontal on areas closer to the toe of the landslide, while the vertical component of deformation increases near the scarp of the landslide. This, together with the interpreted stratigraphy, indicates the kinematics corresponds to a compound landslide. This is consistent with interpreted landslide kinematics of older, more mature landslides in the area that have shown episodes of retrogression and suggests the possibility of a similar future behaviour of the Ripley landslide.
New Trends in Cognitive Aging and Mild Cognitive Impairment
Authors: Facal David , Spuch Carlos , Valladares-Rodriguez Sonia
Published: August 2022

In this editorial, we aim to highlight some lessons learned in our field and to discuss some open questions regarding the continuum between healthy cognitive aging and dementia [...]
Multilevel Modelling of Individual, Community and Regional Level Factors Associated with Insecticide-Treated Net Usage among Pregnant Women in Ethiopia
Authors: Kuse Kenenisa Abdisa , Chikako Teshita Uke , Bacha Reta Habtamu , Hagan John Elvis , Seidu Abdul-Aziz , Ahinkorah Bright Opoku
Published: August 2022

Background: Pregnant women who are infected with malaria usually have more severe symptoms and negative health outcomes than women who are not pregnant, with higher rates of miscarriage, intrauterine demise, premature delivery, low-birth-weight neonates, and neonatal death. Based on evidence from the 2016 Ethiopia Demographic and Health Survey, this study assessed the variation in insecticide-treated nets (ITNs) usage and its associated factors among pregnant women in Ethiopia. Methods: Data from a total of 1122 women who were pregnant at the time of the survey were included in the final analysis. Bivariate and multilevel analyses were conducted. Multilevel modeling with fixed and random coefficients was used to estimate the variation in pregnant women’s ITNs usage across communities (residence areas) and regions of Ethiopia. Results: Out of the total 1122 pregnant women, 58.37% slept under a net and 41.63% did not sleep under nets. Significant variations were observed in pregnant women’s ITNs usage across communities (residence areas) and regions of Ethiopia, with between variations in pregnant women’s ITNs usage across communities (residence areas) and regions. In addition, the region, place of residence, wealth index, educational level, and age of the women as well as whether they believed that mosquito bites cause malaria were significant factors in pregnant women’s usage of ITNs. Pregnant women in Ethiopia had moderate usage of ITNs with varied risk factors at the individual, community, and regional levels. Conclusion: Based on the factors identified, there is a need to implement and/or strengthen programs (e.g., regular sensitization) that intensify high coverage of ITNs for effective malaria prevention in Ethiopia, especially among pregnant women who do not use ITNs.
Validation of the Spanish Version of the Questionnaire on Environmental Awareness in Nursing (NEAT)
Authors: Luque-Alcaraz Olga María , Gomera Antonio , Ruíz África , Aparicio-Martinez Pilar , Vaquero-Abellan Manuel
Published: August 2022

Environmental awareness of the ecological problems caused by this climate crisis and its impact on global health has been growing globally. Nurses are health care agents that usually hurt the environment and contribute to the unsustainability of the care system. Such behavior is perpetuated without the nurses’ awareness and is even magnified by the current pandemic, jeopardizing the health systems and the Sustainable Development Goals. However, there is no Spanish version of any survey that measures the awareness of these agents, only the Nurses Environmental Awareness Tool (NEAT) is available. The current research presents a unique investigation based on a mixed method, using the Spanish version of the NEAT, also called NEAT-es. The results of the mixed analysis (N = 376), a cognitive interview, and descriptive analysis indicated perfect consistency (Cronbach’s alpha > 0.80), better than the original. The survey validation achieved higher values and can be used to measure environmental awareness in Spain and Spanish-speaking countries.
Association between Quality of Life and Physical Functioning in a Gardening Intervention for Cancer Survivors
Authors: Sharma Harsh , Pankratz Vernon S. , Demark-Wahnefried Wendy , Pestak Claire R. , Blair Cindy K.
Published: August 2022

Purpose: To examine potential factors associated with maintaining or improving self-reported physical function (PF) among older cancer survivors participating in a gardening intervention impacted by the Coronavirus 2019 (COVID-19) pandemic. Methods: Thirty cancer survivors completed a home-based gardening intervention to encourage a healthier diet and a more active lifestyle. Device-based measures of physical activity (PA) and surveys to evaluate quality of life (QOL; PROMIS-57 questionnaire) were administered at baseline, mid-intervention (6 months), and post-intervention (9 months). Results: Depression, fatigue, and sleeplessness at baseline were significantly associated with worse average PF scores across follow-up (2.3 to 4.9 points lower for every decrease of 5 points in the QOL score; p-values < 0.02). Worsening of these QOL domains during the intervention was also associated with an additional decrease of 2.1 to 2.9 points in PF over follow-up (p values < 0.01). Better social participation and PA at baseline were significantly associated with better average PF scores during the intervention (2.8 to 5.2 points higher for every 5-point increase in social participation or 30 min more of PA; p values < 0.05). Every 5-point increase in pain at baseline, or increases in pain during the intervention, was associated with decreases of 4.9 and 3.0 points, respectively, in PF. Conclusions: Worse QOL scores before and during the intervention were significantly associated with worse PF over follow-up. Encouraging social participation and PA through interventions such as home-based gardening may improve long-term health among older cancer survivors.
Brixia and qSOFA Scores, Coagulation Factors and Blood Values in Spring versus Autumn 2021 Infection in Pregnant Critical COVID-19 Patients: A Preliminary Study
Authors: Filip Catalina , Covali Roxana , Socolov Demetra , Akad Mona , Carauleanu Alexandru , Vasilache Ingrid Andrada , Scripcariu Ioana Sadiye , Pavaleanu Ioana , Butureanu Tudor , Ciuhodaru Madalina , Boiculese Lucian Vasile , Socolov Razvan
Published: August 2022

(1) Background: From the recent variants of concern of the SARS-CoV-2 virus, in which the delta variant generated more negative outcomes than the alpha, we hypothesized that lung involvement, clinical condition deterioration and blood alterations were also more severe in autumn infection, when the delta variant dominated (compared with spring infections, when the alpha variant dominated), in severely infected pregnant patients. (2) Methods: In a prospective study, all pregnant patients admitted to the ICU of the Elena Doamna Obstetrics and Gynecology Hospital with a critical form of COVID-19 infection—spring group (n = 11) and autumn group (n = 7)—between 1 January 2021 and 1 December 2021 were included. Brixia scores were calculated for every patient: A score, upon admittance; H score, the highest score throughout hospitalization; and E score, at the end of hospitalization. For each day of Brixia A, H or E score, the qSOFA (quick sepsis-related organ failure assessment) score was calculated, and the blood values were also considered. (3) Results: Brixia E score, C-reactive protein, GGT and LDH were much higher, while neutrophil count was much lower in autumn compared with spring critical-form pregnant patients. (4) Conclusions: the autumn infection generated more dramatic alterations than the spring infection in pregnant patients with critical forms of COVID-19. Larger studies with more numerous participants are required to confirm these results.
Sleep Should Be Focused on When Analyzing Physical Activity in Hospitalized Older Adults after Trunk and Lower Extremity Fractures—A Pilot Study
Authors: Kaizu Yoichi , Kasuga Takeaki , Takahashi Yu , Otani Tomohiro , Miyata Kazuhiro
Published: August 2022

Although the importance of resting in bed for hospitalized older adults is known, current methods of interpreting physical activity (PA) recommend the use of a broad definition of sedentary behavior (SB) that includes 0–1.5 metabolic equivalents (METs) of sleep (SL) and sitting. We investigated the characteristics of PA by conducting a cross-sectional study of 25 older adults with trunk and lower extremity fractures. The intensity of their PA was interpreted as SL (0–0.9 METs), SB (1–1.5 METs), low-intensity PA (LIPA: 1.6–2.9 METs), and moderate-to-vigorous PA (MVPA: >3.0 METs). We calculated the correlation coefficients to clarify the relationship between each PA intensity level. Our analyses revealed that the PA time (min/day) was accounted for by SB (53.5%), SL (23.2%), LIPA (22.8%), and MVPA (0.5%). We observed negative correlations between SL and SB (r  =  −0.837) and between SL and LIPA (r  =  −0.705), and positive correlations between SB and LIPA (r  =  0.346) and between LIPA and MVPA (r  =  0.429). SL and SB were also found to have different trends in relation to physical function. These results indicate that SL and SB are trade-offs for PA during the day. Separate interpretations of the SL and SB of older hospitalized adults are thus recommended.
Measuring Nurses’ and Physicians’ Attitudes and Perceptions of the Appropriate Interventions towards Intimate Partner Violence in Saudi Arabia
Authors: Almegewly Wafa Hamad , Hawamdah Sanna , Moussa Fatchima Laouali , Dator Wireen Leila Tanggawohn , Alonezi Anwar , Al-Eissa Majid
Published: August 2022

Background: Intimate partner violence (IPV) is considered the most common form of violence against women worldwide, concerning public health, safety, and human rights. However, little to no studies in Saudi Arabia have explored the attitude and perception of health care providers working in emergency departments toward IPV. This study aimed to measure the attitude and perception of Emergency Room (ER) health care providers towards the appropriate intervention for IPV. Methods: This is a cross-sectional quantitative study. Data was collected from a convenient sample of nurses (n = 88) and physicians (n = 18) working in ER, using Readiness to Manage Intimate Partner Violence Survey (PREMIS). Data was collected from two hospitals in Riyadh, Saudi Arabia, and descriptive analysis was used to analyze the data. Results: The majority of the respondents were aged 18–40 (n = 106, 78%), while 22% were 41–60 years old, 69% were female, and 31% were male. Eighty-five percent were nurses and 15% were physicians. The majority of the respondents did not have any training on IPV and had gained knowledge or skills mostly during their medical/nursing classroom and clinical training. The analysis revealed that the participants had moderate levels of overall preparedness, knowledge about IPV, and perceived knowledge, with a mean score of 2.30, 18.62, and 2.18, respectively. The respondents had low scores in practice issues in new diagnosis (0.91), current screening (1.69), and actions when IPV is identified (0.91). The perceived preparedness and knowledge have a significant positive correlation, as shown by an r value of 0.8476 and a p-value of <0.05. Conclusion: The study shows that participants stated minimal previous IPV knowledge and training. It is necessary to put in place adequate resources and specific training programs to overcome this issue for both ER nurses and physicians.
Nursing Homes: Affiliation to Large Chains, Quality and Public–Private Collaboration
Authors: Aguiar-Díaz Inmaculada , Ruiz-Mallorquí María Victoria , González-López Valcarcel Beatriz
Published: August 2022

The objective of this paper was to estimate the influence of being affiliated with an NH chain on perceived consumer quality, and whether this relationship is affected by maintaining a collaboration agreement with public administrations. We used a combination of theoretical foundations: (1) From the consumer perspective, we focussed on online reviews of the quality of nursing homes (NHs); (2) from the industrial organisation literature, we proposed arguments regarding the advantages and disadvantages of belonging to a chain; (3) the theory of transaction costs was used to explain public–private collaboration. The study was carried out on a sample of 642 chain-affiliated Spanish NHs, with data from quality scores downloaded from the website topMayores.es. We distinguished between the six largest chains and the rest. We applied linear regression models. The results show that NHs affiliated with one of the largest NH chains obtained worse quality scores in the assessment made by users, although quality scores improved for the largest chains of NHs involved in an agreement with the public administration.
Sociodemographic and Personal Predictors of Exclusive Breastfeeding in Pregnant Mexican Women Using Public Health Services
Authors: Serrano-Alvarado Karina , Castro-Porras Lilia V. , Astudillo-García Claudia I. , Rojas-Russell Mario E.
Published: August 2022

Exclusive breastfeeding (EBF) is a cost-effective healthy behavior for the mother–child dyad. Globally, rates of EBF are low. Little research has been conducted on the joint role of modifiable and nonmodifiable variables in pregnant women’s decision-making. The aim was to develop and test a model that used personal and sociodemographic factors to predict whether pregnant women who use public healthcare services plan to breastfeed. In a nonprobabilistic sample of 728 pregnant Mexican women, self-efficacy, the planned behavior theory constructs, and the intention to breastfeed (BFI) were measured. A total 60% of the sample was randomly chosen to develop a predictive multivariate logistic regression model. The model was validated in the remaining 40%. Women in the highest tertiles of attitudes and self-efficacy had fourfold increased chances of having a high BFI (OR 4.2, 95% CI [2.4, 7.4]). Working was associated with a decreased intention to exclusively breastfeed (OR 0.61, 95% CI [0.37, 0.98]). The model predicted BFI with a sensitivity of 38.3% and specificity of 82.2%. While personal variables predict the BFI, working decreases women’s chances of breastfeeding. The results can be utilized to develop primary prevention strategies to help mothers who use public health services to breastfeed.
Antenatal Assessment of the Prognosis of Congenital Diaphragmatic Hernia: Ethical Considerations and Impact for the Management
Authors: Le Duc Kévin , Mur Sébastien , Sharma Dyuti , Sfeir Rony , Vaast Pascal , Boukhris Mohamed Riadh , Benachi Alexandra , Storme Laurent
Published: August 2022

Congenital diaphragmatic hernia (CDH) is associated with abnormal pulmonary development, which is responsible for pulmonary hypoplasia with structural and functional abnormalities in pulmonary circulation, leading to the failure of the cardiorespiratory adaptation at birth. Despite improvement in treatment options and advances in neonatal care, mortality remains high, at close to 15 to 30%. Several risk factors of mortality and morbidities have been validated in fetuses with CDH. Antenatal assessment of lung volume is a reliable way to predict the severity of CDH. The two most commonly used measurements are the observed/expected lung to head ratio (LHRo/e) and the total pulmonary volume (TPV) on MRI. The estimation of total pulmonary volume (TPVo/e) by means of prenatal MRI remains the gold standard. In addition to LHR and TPV measurements, the position of the liver (up, in the thorax or down, in the abdomen) also plays a role in the prognostic evaluation. This prenatal prognostic evaluation can be used to select fetuses for antenatal surgery, consisting of fetoscopic endoluminal tracheal occlusion (FETO). The antenatal criteria of severe CDH with an ascended liver (LHRo/e or TPVo/e < 25%) are undoubtedly associated with a high risk of death or significant morbidity. However, despite the possibility of estimating the risk in antenatal care, it is difficult to determine what is in the child’s best interest, as there still are many uncertainties: (1) uncertainty about individual short-term prognosis; (2) uncertainty about long-term prognosis; and (3) uncertainty about the subsequent quality of life, especially when it is known that, with a similar degree of disability, a child’s quality of life varies from poor to good depending on multiple factors, including family support. Nevertheless, as the LHR decreases, the foreseeable “burden” becomes increasingly significant, and the expected benefit is increasingly unlikely. The legal and moral principle of the proportionality of medical procedures, as well as the prohibition of “unreasonable obstinacy” in all investigations or treatments undertaken, is necessary in these situations. However, the scientific and rational basis for assessing the long-term individual prognosis is limited to statistical data that do not adequately reflect individual risk. The risk of self-fulfilling prophecies should be kept in mind. The information given to parents must take this uncertainty into account when deciding on the treatment plan after birth.
The COVID-19 Pandemic and Patient Safety Culture: A Cross-Sectional Study among Community Pharmacies in Jordan
Authors: Abu Assab Mohammad , Jaber Deema , Basheer Haneen , Abu Assab Hanadi , Al-Atram Haya
Published: August 2022

The COVID-19 pandemic has dramatically imposed stressful conditions that may impact the ability of healthcare staff to provide safe and effective care. Research on patient safety culture among community pharmacies during the pandemic is limited. This study aimed to assess the patient safety culture among community pharmacies in Jordan during the COVID-19 pandemic. Pharmacists and pharmacy assistants from 450 community pharmacies were approached through online means, with 378 answering the questionnaire written in Arabic that had been adapted from the Community Pharmacy Survey on Patient Safety Culture (PSOPSC). This study showed that various patient safety standards were addressed to a high degree during the COVID-19 pandemic, as represented by the high positive response rate (PRR) measures that were mainly observed in the dimensions “Teamwork” (90.1%), “Patient Counseling” (85.2%), and “Staff Training and Skills” (82.7%). Furthermore, significantly higher PRR scores for the “Teamwork”, “Staffing, Work Pressure, and Pace”, “Response to Mistakes”, “Organizational Learning—Continuous Improvement”, and “Overall Perceptions of Patient Safety” dimensions were observed among participants who worked in independent pharmacies than those who worked in chain pharmacies. Despite an overall positive patient safety culture in the current context of community pharmacies in Jordan during the COVID-19 pandemic, pitfalls were observed in the “Staffing, Work Pressure, and Pace” dimension.
Doctors’ Preferences in the Selection of Patients in Online Medical Consultations: An Empirical Study with Doctor–Patient Consultation Data
Authors: Lu Yingjie , Wang Qian
Published: August 2022

Online medical consultation (OMC) allows doctors and patients to communicate with each other in an online synchronous or asynchronous setting. Unlike face-to-face consultations in which doctors are only passively chosen by patients with appointments, doctors engaging in voluntary online consultation have the option of choosing patients they hope to treat when faced with a large number of online questions from patients. It is necessary to characterize doctors’ preferences for patient selection in OMC, which can contribute to their more active participation in OMC services. We proposed to exploit a bipartite graph to describe the doctor–patient interaction and use an exponential random graph model (ERGM) to analyze the doctors’ preferences for patient selection. A total of 1404 doctor–patient consultation data retrieved from an online medical platform in China were used for empirical analysis. It was found that first, mildly ill patients will be prioritized by doctors, but the doctors with more professional experience may be more likely to prefer more severely ill patients. Second, doctors appear to be more willing to provide consultation services to patients from urban areas, but the doctors with more professional experience or from higher-quality hospitals give higher priority to patients from rural and medically underserved areas. Finally, doctors generally prefer asynchronous communication methods such as picture/text consultation, while the doctors with more professional experience may be more willing to communicate with patients via synchronous communication methods, such as voice consultation or video consultation.
Mental Wellbeing of Indonesian Students: Mean Comparison with UK Students and Relationships with Self-Compassion and Academic Engagement
Authors: Kotera Yasuhiro , Lieu Jenai , Kirkman Ann , Barnes Kristian , Liu Gillian H. T. , Jackson Jessica , Wilkes Juliet , Riswani Riswani
Published: August 2022

The number of Indonesian students in higher education has been increasing rapidly. However, many Indonesian university students report experiencing mental distress. Research on student wellbeing found that self-compassion (i.e., being kind towards oneself in challenging times) and academic engagement (i.e., a commitment and purposeful effort toward study) are essential to students’ mental wellbeing. With the present study, we aimed to assess the mental wellbeing of Indonesian students. A convenience sample of 156 Indonesian students completed self-report measures on mental wellbeing, self-compassion and academic engagement (consisting of vigour, dedication and absorption). To contextualise their mental wellbeing, data from Indonesian students were compared with those from 145 UK students using Welch t-tests. Correlation, regression and mediation analyses were then performed to examine the relationships among these variables. Indonesian students had higher levels of self-compassion and absorption and a lower level of dedication than UK students. Self-compassion and academic engagement explained 36% of variance in mental wellbeing. Self-compassion and vigour were identified as significant predictors of mental wellbeing, whereas self-compassion was the strongest predictor. Lastly, vigour did not mediate the pathway from self-compassion to mental wellbeing. Interventions to support self-compassion and academic engagement, especially vigour, in Indonesian students are recommended to support their mental wellbeing.
Towards Informed Water Resources Planning and Management
Authors: Reggiani Paolo , Talbi Amal , Todini Ezio
Published: August 2022

In Water Resources Planning and Management, decision makers, although unsure of future outcomes, must take the most reliable and assuring decisions. Deterministic and probabilistic prediction techniques, combined with optimization tools, have been widely used to meet the objective of improving planning as well as management. Bayesian decision approaches are available to link probabilistic predictions to optimized decision schemes, but scientists are not fully able to express themselves in a language familiar to decision makers, who fear basing their decisions on “uncertain” forecasts in the vain belief that deterministic forecasts are more informative and reliable. This situation is even worse in the case of climate change projections, which bring additional degrees of uncertainty into the picture. Therefore, a need emerges to create a common approach and means of communication between scientists, who deal with optimization tools, probabilistic predictions and long-term projections, and operational decision makers, who must be facilitated in understanding, accepting, and acknowledging the benefits arising from operational water resources management based on probabilistic predictions and projections. Our aim here was to formulate the terms of the problem and the rationale for explaining and involving decision makers with the final objective of using probabilistic predictions/projections in their decision-making processes.
The Effects of Regular Physical Activity and Playing Video Games on Reaction Time in Adolescents
Authors: Klasnja Aleksandar , Milenovic Natasa , Lukac Sonja , Knezevic Aleksandar , Klasnja Jelena , Karan Rakic Vedrana
Published: August 2022

Reaction time is of great importance in life. In both sports and video games, movements of participants are conditioned by different visual, acoustic and somatosensory signals. The aim of this research was to determine whether reaction time is influenced by regular physical activity and playing video games in adolescents. The study included 41 female and 26 male students, aged 10–14 years. Questionnaires about habits related to regular physical activity and playing video games were given to the examinees. Afterwards, the reaction time was determined for visual stimuli, via a computer program. The obtained results show that there is a statistically significant difference in the value of the reaction time of children who are regularly engaged in physical activity relative to those who play video games ((0.327 ± 0.081) s vs. (0.403 ± 0.137) s, p = 0.013), while there is no statistically significant difference in reaction time between children who equally participate in physical activity and video games ((0.386 ± 0.134) s) compared to those who regularly practice physical activity (p = 0.156), and those who only play video games (p = 0.610). Physical activity can decrease reaction time in children, but further studies are needed to elucidate the impact of regular physical activity and gaming on the developing adolescent brain.