bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep Convolutional Neural Networks With Ensemble Learning and Generative Adversarial Networks for Alzheimer’s Disease Image Data Classification
Authors: Logan Robert , Williams Brian G. , Ferreira da Silva Maria , Indani Akash , Schcolnicov Nicolas , Ganguly Anjali , Miller Sean J.
Published: August 2021

Recent advancements in deep learning (DL) have made possible new methodologies for analyzing massive datasets with intriguing implications in healthcare. Convolutional neural networks (CNN), which have proven to be successful supervised algorithms for classifying imaging data, are of particular interest in the neuroscience community for their utility in the classification of Alzheimer’s disease (AD). AD is the leading cause of dementia in the aging population. There remains a critical unmet need for early detection of AD pathogenesis based on non-invasive neuroimaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography (PET). In this comprehensive review, we explore potential interdisciplinary approaches for early detection and provide insight into recent advances on AD classification using 3D CNN architectures for multi-modal PET/MRI data. We also consider the application of generative adversarial networks (GANs) to overcome pitfalls associated with limited data. Finally, we discuss increasing the robustness of CNNs by combining them with ensemble learning (EL).
Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders
Authors: Guo Changyong , Ma Yao-Ying
Published: August 2021

Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. Other than the previously established signaling pathways of excitotoxicity, which depend on the excessive release of glutamate from axon terminals or over-activation of NMDA receptors (NMDARs), Ca2+ influx-triggered excitotoxicity through Ca2+-permeable (CP)-AMPA receptors (AMPARs) is detected in multiple disease models. In this review, both acute brain insults (e.g., brain trauma or spinal cord injury, ischemia) and chronic neurological disorders, including Epilepsy/Seizures, Huntington’s disease (HD), Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), chronic pain, and glaucoma, are discussed regarding the CP-AMPAR-mediated excitotoxicity. Considering the low expression or absence of CP-AMPARs in most cells, specific manipulation of the CP-AMPARs might be a more plausible strategy to delay the onset and progression of pathological alterations with fewer side effects than blocking NMDARs.
Functional Topography of Auditory Areas Derived From the Combination of Electrophysiological Recordings and Cortical Electrical Stimulation
Authors: Trébuchon Agnès , Alario F.-Xavier , Liégeois-Chauvel Catherine
Published: August 2021

The posterior part of the superior temporal gyrus (STG) has long been known to be a crucial hub for auditory and language processing, at the crossroad of the functionally defined ventral and dorsal pathways. Anatomical studies have shown that this “auditory cortex” is composed of several cytoarchitectonic areas whose limits do not consistently match macro-anatomic landmarks like gyral and sulcal borders. The only method to record and accurately distinguish neuronal activity from the different auditory sub-fields of primary auditory cortex, located in the tip of Heschl and deeply buried in the Sylvian fissure, is to use stereotaxically implanted depth electrodes (Stereo-EEG) for pre-surgical evaluation of patients with epilepsy. In this prospective, we focused on how anatomo-functional delineation in Heschl’s gyrus (HG), Planum Temporale (PT), the posterior part of the STG anterior to HG, the posterior superior temporal sulcus (STS), and the region at the parietal-temporal boundary commonly labeled “SPT” can be achieved using data from electrical cortical stimulation combined with electrophysiological recordings during listening to pure tones and syllables. We show the differences in functional roles between the primary and non-primary auditory areas, in the left and the right hemispheres. We discuss how these findings help understanding the auditory semiology of certain epileptic seizures and, more generally, the neural substrate of hemispheric specialization for language.
Contralateral and Ipsilateral Interactions in the Somatosensory Pathway in Healthy Humans
Authors: Ishii Daisuke , Ishibashi Kiyoshige , Yuine Hiroshi , Takeda Kotaro , Yamamoto Satoshi , Kaku Yuki , Yozu Arito , Kohno Yutaka
Published: August 2021

Hyper-adaptability, the ability to adapt to changes in the internal environment caused by neurological disorders, is necessary to recover from various disabilities, such as motor paralysis and sensory impairment. In the recovery from motor paralysis, the pre-existing neural pathway of the ipsilateral descending pathway, which is normally suppressed and preserved in the course of development, is activated to contribute to the motor control of the paretic limb. Conversely, in sensory pathways, it remains unclear whether there are compensatory pathways which are beneficial for the recovery of sensory impairment due to damaged unilateral somatosensory pathways, such as thalamic hemorrhage. Here, we investigated the interaction between the left and right somatosensory pathways in healthy humans using paired median nerve somatosensory evoked potentials (SEPs). Paired median nerve SEPs were recorded at CP3 and CP4 with a reference of Fz in the International 10–20 System. The paired median nerve stimulation with different interstimulus intervals (ISIs; 1, 2, 3, 5, 10, 20, 40, 60, and 100 ms) was performed to test the influence of the first stimulus (to the right median nerve) on the P14, P14/N20, and N20/P25 components induced by the second stimulus (left side). Results showed that the first stimulation had no effect on SEP amplitudes (P14, P14/N20, and N20/P25) evoked by the second stimulation in all ISI conditions, suggesting that there might not be a neural connectivity formed by a small number of synapses in the left–right interaction of the somatosensory pathway. Additionally, the somatosensory pathway may be less diverse in healthy participants.
On the Validity of Adipogenic Cell Lines as Model Systems for Browning Processes: In Authentic Brown, Brite/Beige, and White Preadipocytes, There is No Cell-Autonomous Thermogenic Recruitment by Green Tea Compounds
Authors: Otton Rosemari , Petrovic Natasa , Cannon Barbara , Nedergaard Jan
Published: August 2021

The potential ability of nutritional compounds to induce or enhance the browning of adipocytes has attracted large interest as a workable means of combatting the obesity epidemic. Green tea compounds are discussed as such inducers of an enhanced thermogenic capacity and activity. However, the cell-autonomous effects of green tea compounds on adipocytes have until now only been demonstrated in adipogenic cell lines (3T3-L1 and 3T3-F442A), i.e., cells of undefined tissue lineage. In this study, we examine the ability of green tea compounds to cell-autonomously induce thermogenic recruitment in authentic brown and brite/beige adipocytes in vitro. In primary brown adipocytes, the green tea compounds suppressed basal UCP1 gene expression, and there was no positive interaction between the compounds and adrenergic stimulation. In white adipocytes, green tea compounds decreased both basal and norepinephrine-induced UCP1 mRNA levels, and this was associated with the suppression of cell differentiation, indicated by reduced lipogenic gene expression and lipid accumulation. A lack of interaction between rosiglitazone and green tea compounds suggests that the green tea compounds do not directly interact with the PPARγ pathway. We conclude that there is a negative effect of the green tea compounds on basal UCP1 gene expression, in both brown and white primary adipocytes, in contrast to the positive effects earlier reported from studies in adipogenic cell lines. We posit that the epigenetic status of the adipogenic cell lines is fundamentally different from that of genuine brown and white adipocytes, reflected, e.g., in several-thousand-fold differences in UCP1 gene expression levels. Thus, results obtained with adipogenic cell lines cannot unreservedly be extrapolated as being relevant for authentic effects in brown and white adipocytes. We suggest that this conclusion can be of general concern for studies attempting to establish physiologically relevant cell-autonomous effects.
HOXA5 Is Recognized as a Prognostic-Related Biomarker and Promotes Glioma Progression Through Affecting Cell Cycle
Authors: Ding Fengqin , Chen Ping , Bie Pengfei , Piao Wenhua , Cheng Quan
Published: August 2021

Glioma is malignant tumor derives from glial cells in the central nervous system. High-grade glioma shows aggressive growth pattern, and conventional treatments, such as surgical removal and chemo-radiotherapy, archive limitation in the interference of this process. In this work, HOXA5, from the HOX family, was identified as a glioma cell proliferation-associated factor by investigating its feature in the TCGA and CGGA data set. High HOXA5 expression samples contain unfavorable clinical features of glioma, including IDH wild type, un-methylated MGMT status, non-codeletion 1p19q status, malignant molecular subtype. Survival analysis indicates that high HOXA5 expression samples are associated with worse clinical outcome. The CNVs and SNPs profile difference further confirmed the enrichment of glioma aggressive related biomarkers. In the meantime, the activation of DNA damage repair-related pathways and TP53-related pathways is also related to HOXA5 expression. In cell lines, U87MG and U251, by interfering HOXA5 expression significantly inhibit glioma progression and apoptosis, and cell cycle is arrested at the G2/M phase. Collectively, increased HOXA5 expression can promote glioma progression via affecting glioma cell proliferation.
Opioids and Chronic Pain: An Analytic Review of the Clinical Evidence
Authors: Nadeau Stephen E. , Wu Jeffrey K. , Lawhern Richard A.
Published: August 2021

We conducted an analytic review of the clinical scientific literature bearing on the use of opioids for treatment of chronic non-cancer pain in the United States. There is substantial, albeit not definitive, scientific evidence of the effectiveness of opioids in treating pain and of high variability in opioid dose requirements and side effects. The estimated risk of death from opioid treatment involving doses above 100 MMED is ~0.25%/year. Multiple large studies refute the concept that short-term use of opioids to treat acute pain predisposes to development of opioid use disorder. The prevalence of opioid use disorder associated with prescription opioids is likely <3%. Morbidity, mortality, and financial costs of inadequate treatment of the 18 million Americans with moderate to severe chronic pain are high. Because of the absence of comparative effectiveness studies, there are no scientific grounds for considering alternative non-pharmacologic treatments as an adequate substitute for opioid therapy but these treatments might serve to augment opioid therapy, thereby reducing dosage. There are reasons to question the ostensible risks of co-prescription of opioids and benzodiazepines. As the causes of the opioid crisis have come into focus, it has become clear that the crisis resides predominantly in the streets and that efforts to curtail it by constraining opioid treatment in the clinic are unlikely to succeed.
Assessment of Body Posture of Children With Chest Pain
Authors: Zmyślna Anna , Żurawski Arkadiusz Łukasz , Śliwiński Grzegorz , Śliwiński Zbigniew Włodzimierz , Kiebzak Wojciech Piotr
Published: August 2021

Objective: An increase in the appearance of chest pain among children is observed globally. The authors present various reasons for their appearance. As can be seen from numerous observations, the majority of cases are not related to the pathology of the circulatory system. Increasingly, studies on the causes of chest pain in children show their association with musculoskeletal disorders.

Aim: of the work was assessment of body posture in children with chest pain using the Diers Formetric 4D system.

Methods: The study involved a group of 184 female and male children, aged 7–12 years. The study group consisted of 64 patients with chest pain. The children from this group were diagnosed with functional chest pain by a cardiologist. The control group consisted of 120 patients without chest pain. The study included the assessment of body posture using the DIERS Formetric system.

Results: The analysis of the results obtained during the study showed that among the children with chest pain, there are statistically significant irregularities in the parameters determining body posture compared to the control group.

Comparing the study group with the control group, there is a statistically significant difference in the lateral deviation of VPDM (rms) (mm) (p = 0.001). Both children from the test group aged 9–10 and 11–12 obtained higher results than their peers from the control group. In the group of the youngest children in terms of the lateral deviation of VPDM (rms) (mm), increasing the number of children under study would contribute to significant differences in this variable.

In the study group, among children aged 9–10 years, there were also statistically significant abnormalities regarding trunk imbalance and pelvic skewness compared to the children of the same age in the control group.

Conclusions: Irregularities in the parameters determining body posture may cause chest pain in children.
Midterm Outcomes of Crosslinked Acellular Bovine Jugular Vein Conduit for Right Ventricular Outflow Tract Reconstruction
Authors: Qian Tao , Wu Zhong-Shi , Hu Jian-Guo , Yang Yi-Feng , Wu Qin , Lu Ting , Huang Can , Li Jia
Published: August 2021

Objectives: Conduits for reconstructing right ventricular outflow tract (RVOT) in children with congenital heart disease have evolved for better durability over the past decades, but conduits failure remains common. We designed decellularized and photooxidatively crosslinked bovine jugular vein conduit (DP-BJVC) and now aim to evaluate the midterm results of DP-BJVC for RVOT reconstruction.

Methods: Ninety patients (median age: 4.2 years) undergoing RVOT reconstruction using DP-BJVC were prospectively followed for median of 4.7 years (range: 0.2–16.1 years). Kaplan–Meier analysis was used to examine the survival, freedom from conduit explantation and catheter-based reintervention. Risk factors were analyzed with Cox regression analysis.

Results: Follow-up was completed in 92% of patients. There were five (5.6%) early deaths. The 10-year survival rate was 85.2%, with palliative procedure at DP-BJVC implantation as the risk factor. The 10-year freedom from conduit explantation and reintervention were 84.4 and 67.3% respectively, with previous cardiac operation as the only risk factor for explantation. Complications during the follow-up included conduit stenosis (peak gradient ≥50 mmHg) in 12 (12.9%), severe regurgitation in 2 (2.4%), and infective endocarditis in 2 (2.4%). The annual increase in gradient was highest in the first year (P = 0.003), but not appreciably afterwards. The echo-measured annulus diameter trends to increase by an average of 0.37 mm per year. Calcification appeared mild in the failed conduits.

Conclusions: DP-BJVC provides satisfactory durability and functionality for RVOT reconstruction for children, with low morbidity of stenosis and endocarditis, as well as increase in diameter mildly with age in midterm follow-ups.
Biological Ingredient Analysis of Traditional Herbal Patent Medicine Fuke Desheng Wan Using the Shotgun Metabarcoding Approach
Authors: Xie Hongbo , Zhao Qing , Shi Mengmeng , Kong Weijun , Mu Weishan , Li Baoli , Zhao Jingyi , Zhao Chunying , Jia Jing , Liu Jinxin , Shi Linchun
Published: August 2021

With the widespread use of traditional medicine around the world, the safety and efficacy of traditional herbal patent medicine have become an increasing concern to the public. However, it is difficult to supervise the authenticity of herbal materials in mixed herbal products according to the current quality standards, especially for traditional herbal patent medicine, with a distinct variance in the dosage of herbal materials. This study utilized the shotgun metabarcoding approach to analyze the biological ingredients of Fuke Desheng Wan (FKDSW), which is an effective traditional herbal product for the treatment of dysmenorrhea. Six herbal materials were collected, and a lab-made mock FKDSW sample was produced to establish a method for the authentication assessment of biological ingredients in traditional herbal patent medicine based on shotgun metabarcoding. Furthermore, four commercial FKDSW samples were collected to verify the practicality of the shotgun metabarcoding approach. Then, a total of 52.16 Gb raw data for 174 million paired-end reads was generated using the Illumina NovaSeq sequencing platform. Meanwhile, 228, 23, and 14 operational taxonomic units (OTUs) were obtained for the ITS2, matK, and rbcL regions, respectively, after bioinformatic analysis. Moreover, no differences were evident between the assembly sequences obtained via shotgun metabarcoding and their corresponding reference sequences of the same species obtained via Sanger sequencing, except for part of the ITS2 and matK assembly sequences of Paeonia lactiflora Pall., Saussurea costus (Falc.) Lipsch. and Bupleurum chinense DC. with 1–6 different bases. The identification results showed that all six prescribed ingredients were successfully detected and that the non-authentic ingredient of Bupleuri Radix (Chaihu, Bupleurum chinense DC. or Bupleurum scorzonerifolium Willd.) was found in all the commercial samples, namely Bupleurum falcatum L. Here, 25 weed species representing 16 genera of ten families were detected. Moreover, 26 fungal genera belonging to 17 families were found in both lab-made and commercial FKDSW samples. This study demonstrated that the shotgun metabarcoding approach could overcome the biased PCR amplification and authenticate the biological ingredients of traditional herbal patent medicine with a distinct variance in the dosage of the herbal materials. Therefore, this provides an appropriate evaluation method for improving the safety and efficacy of traditional herbal patent medicine.
Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects
Authors: Wu Xianbo , Huang Jianli , Wang Jie , Xu Yihua , Yang Xinwei , Sun Minghan , Shi Jianyou
Published: August 2021

Pulmonary fibrosis is a fatal chronic progressive respiratory disease, characterized by continuous scarring of the lung parenchyma, leading to respiratory failure and death. The incidence of PF has increased over time. There are drugs, yet, there are some limitations. Hence, it is of importance to find new therapies and new drugs to replace the treatment of pulmonary fibrosis. In recent years, there have been a great number of research reports on the treatment of traditional Chinese medicine polysaccharides in various system fields. Among them, the treatment of PF has also gained extensive attention. This review summarized the source of polysaccharides, the drug activity of traditional Chinese medicine, and the protective effects on targets of Pulmonary fibrosis. We hope it can inspire researchers to design and develop polysaccharides, serving as a reference for potential clinical therapeutic drugs.
An Economy-Climate Model for Quantitatively Projecting the Impact of Future Climate Change and Its Application
Authors: Chou Jieming , Xu Yuan , Dong Wenjie , Zhao Weixing , Li Jiangnan , Li Yuanmeng
Published: August 2021

Quantitatively projecting the impact of future climate change on the socio-economy and exploring its internal mechanism are of great practical significance to adapt to climate change and prevent climate risks. Based on the economy-climate (C-D-C) model, this paper introduces a yield impact of climate change (YICC) model that can quantitatively project the climate change impact. The model is based on the YICC as its core concept and uses the impact ratio of climate change (IRCC) indicator to assess the response of the economic system to climate change over a long period of time. The YICC is defined as the difference between the economic output under changing climate condition and that under assumed invariant climate condition. The IRCC not only reflects the sensitivity of economic output to climate change but also reveals the mechanism of the nonlinear interaction between climate change and non-climatic factors on the socio-economic system. Using the main grain-producing areas in China as a case study, we use the data of the ensemble average of 5 GCMs in CMIP6 to project the possible impact of climate change on grain production in the next 15–30 years under three future scenarios (SSP1-2.6, SSP2-4.5, SSP5-8.5). The results indicate that the long-term climate change in the future will have a restraining effect on production in North region and enhance production in South region. From 2021 to 2035, climate change will reduce production by 0.60–2.09% in North region, and increase production by 1.80–9.01% in South region under three future scenarios. From 2021 to 2050, compared with the climate change impact in 2021–2035, the negative impact of climate change on production in North region will weaken, and the positive impact on production in South region will enhance with the increase in emission concentration. Among them, climate change will reduce grain output in North region by 0.52–1.99%, and increase output in South region by 1.35–9.56% under the three future scenarios. The combination of economic results and climate change research is expected to provide scientific support for further revealing the economic mechanism of climate change impacts.
Solution NMR of Nanoparticles in Serum: Protein Competition Influences Binding Thermodynamics and Kinetics
Authors: Xu Joanna Xiuzhu , Fitzkee Nicholas C.
Published: August 2021

The spontaneous formation of a protein corona on a nanoparticle surface influences the physiological success or failure of the synthetic nanoparticle as a drug carrier or imaging agent used in vivo. A quantitative understanding of protein-nanoparticle interactions is therefore critical for the development of nanoparticle-based therapeutics. In this perspective, we briefly discuss the challenges and limitations of current approaches used for studying protein-nanoparticle binding in a realistic biological medium. Subsequently, we demonstrate that solution nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to monitor protein competitive binding in a complex serum medium in situ. Importantly, when many serum proteins are competing for a gold nanoparticle (AuNP) surface, solution NMR is able to detect differences in binding thermodynamics, and kinetics of a tagged protein. Combined with other experimental approaches, solution NMR is an invaluable tool to understand protein behavior in the nanoparticle corona.
Functional Characterisation of Banana (Musa spp.) 2-Oxoglutarate-Dependent Dioxygenases Involved in Flavonoid Biosynthesis
Authors: Busche Mareike , Acatay Christopher , Martens Stefan , Weisshaar Bernd , Stracke Ralf
Published: August 2021

Bananas (Musa) are non-grass, monocotyledonous, perennial plants that are well known for their edible fruits. Their cultivation provides food security and employment opportunities in many countries. Banana fruits contain high levels of minerals and phytochemicals, including flavonoids, which are beneficial for human nutrition. To broaden the knowledge on flavonoid biosynthesis in this major crop plant, we aimed to identify and functionally characterise selected structural genes encoding 2-oxoglutarate-dependent dioxygenases, involved in the formation of the flavonoid aglycon.Musacandidates genes predicted to encode flavanone 3-hydroxylase (F3H), flavonol synthase (FLS) and anthocyanidin synthase (ANS) were assayed. Enzymatic functionalities of the recombinant proteins were confirmedin vivousing bioconversion assays. Moreover, transgenic analyses in correspondingArabidopsis thalianamutants showed thatMusaF3H,MusaFLSandMusaANSwere able to complement the respective loss-of-function phenotypes, thus verifying functionality of the enzymesin planta. Knowledge gained from this work provides a new aspect for further research towards genetic engineering of flavonoid biosynthesis in banana fruits to increase their antioxidant activity and nutritional value.
Melatonin Enhances Seed Germination and Seedling Growth of Medicago sativa Under Salinity via a Putative Melatonin Receptor MsPMTR1
Authors: Yu Ruonan , Zuo Tiantian , Diao Pengfei , Fu Jiabin , Fan Yanyan , Wang Yue , Zhao Qiqi , Ma Xuesong , Lu Wenting , Li Aoga , Wang Ru , Yan Fang , Pu Li , Niu Yiding , Wuriyanghan Hada
Published: August 2021

Alfalfa (Medicago sativa L.) is an important forage crop, and salt stress is a major limiting factor in its yield. Melatonin (MT) is a multi-regulatory molecule in plants. We showed that basal MT content was positively correlated with the salt tolerance degree of different alfalfa varieties. MT and its precursor 5-HT fully recovered seed germination while partially ameliorated seedling growth of salt-stressed alfalfa. The 5-HT showed some divergent effects from MT with regards to growth amelioration under salinity. Salt stress caused stunted plant growth in soil culture, while MT ameliorated it by elevating plant height, fresh weight, branching number, and chlorophyll content. Silencing of a putative MT receptor, MsPMTR1, which was shown to be membrane-localized, abolished the ameliorative effects of MT on salt-stressed alfalfa seedling growth, while overexpression of MsPMTR1 improved plant growth under salt stress. The RNA sequencing analysis showed that nine pathway genes were specifically induced by MT treatment compared with salt stress. These MT-responsive differentially expressed genes include basal metabolic pathway genes, such as “ribosome, elongation factor,” “sugar and lipid metabolism,” and “photosynthesis” and stress-related genes encoding “membrane integrity” related proteins, heat shock protein, peroxidase/oxidoreductase, and protease. Several abiotic stress response-related genes, such as DRE, ARF, HD-ZF, MYB, and REM were repressed by NaCl treatment while induced by MT treatment. In summary, we demonstrated the importance of MsPMTR1 in MT-mediated salt tolerance in alfalfa, and we also analyzed the regulatory mechanism of MT during alfalfa seed germination under salt stress.
Investigation of L2/Ln Pragmatic Competence: Its Core and Route Map
Authors: Mao Tiaoyuan
Published: August 2021

How to use language properly and acquire the capacity for language use has become the focus of linguists and philosophers for centuries. Therefore, pragmatic competence underlying language use arouses enormous interests of language acquisition practitioners. This study reveals the core properties of various models or theories of pragmatic competence, such as the communicative componential models, the form-function mapping proposal of the functionalist, the tripartite cognitive model, and the current integrated model of pragmatic competence. The common core includes (but not limited to) integration of thought and communication, one uniform pragmatic mechanism, dynamic form-function mapping, and complementarity between grammatical and pragmatic competences. With the findings as a departure, a brief outline for further investigation of pragmatic competence is proposed finally, including pathological and neurobiological examination of pragmatic competence.
Adaptability and High School Students’ Online Learning During COVID-19: A Job Demands-Resources Perspective
Authors: Martin Andrew J. , Collie Rebecca J. , Nagy Robin P.
Published: August 2021

The present study investigated the role of adaptability in helping high school students navigate their online learning during a period of COVID-19 that entailed fully or partially remote online learning. Drawing on Job Demands-Resources theory and data from a sample of 1,548 Australian high school students in nine schools, we examined the role of adaptability in predicting students’ online learning self-efficacy in mathematics and their end of year mathematics achievement. It was found that beyond the effects of online learning demands, online and parental learning support, and background attributes, adaptability was significantly associated with higher levels of online learning self-efficacy and with gains in later achievement; online learning self-efficacy was also significantly associated with gains in achievement—and significantly mediated the relationship between adaptability and achievement. These findings confirm the role of adaptability as an important personal resource that can help students in their online learning, including through periods of remote instruction, such as during COVID-19.
Beginning EFL Teachers' Emotional Labor Strategies in the Chinese Context
Authors: Li Hanxi , Liu Honggang
Published: August 2021

Teachers' emotional labor strategies have been explored in different cultural contexts. However, beginning English as a foreign language (EFL) teachers have received scant research attention. This study seeks to conceptualize emotional labor strategies among Chinese beginning EFL teachers and investigate their general profiles. The developed Beginning EFL Teachers' Emotional Labor Strategy Scale was assessed among 484 Chinese beginning secondary school EFL teachers. A final 20-item scale was obtained after a series of reliability (e.g., item analysis, internal consistency, composite reliability) and validity tests (e.g., construct validity, convergent validity, discriminant validity). The confirmatory factor analysis results supported the four-dimensional structure of emotional labor strategies in the beginning EFL teacher sample, encompassing surface acting, deep acting, positive consonance, and negative consonance. In addition, participants reported high levels of positive consonance and deep acting, and low levels of surface acting and negative consonance. Possible reasons for this are discussed in reference to the EFL educational context in China. The findings provide insights into sustainable development for Chinese beginning secondary school EFL teachers.
Toward the Association Between EFL/ESL Teachers' Work Engagement and Their Students' Academic Engagement
Authors: Zhang Aizhen , Yang Yang
Published: August 2021

Given the fact that EFL/ESL students' academic engagement is of high importance for their learning success, numerous studies have been carried out to identify factors contributing to students' engagement. However, the role of teacher personal factors, notably teacher work engagement has received scant attention. Moreover, no review study has been conducted on this issue. Accordingly, the present review intends to explicate the multidimensional essence of teacher work engagement and student academic engagement and the association between these constructs. In light of the theoretical and empirical evidence, the role of EFL/ESL teachers' work engagement in improving their students' academic engagement was proved. The pedagogical implications of the findings are also highlighted.
Influence of Family Dynamics on Stigma Experienced by Patients With Schizophrenia: Mediating Effect of Quality of Life
Authors: Wang Ling , Chen Yanhua , Hu Chengping , Qin Hongyun
Published: August 2021

Background: Stigma is a barrier to schizophrenia recovery; thus, screening the factors that affect stigma experienced by patients with schizophrenia and exploring the interactions between each factor are critical for improved treatment. The purpose of this study was to demonstrate the relationship between quality of life (QoL), family dynamics, and stigma in patients with schizophrenia.

Methods: A total of 447 participants with schizophrenia were recruited in the study, namely, 281 community patients and 166 inpatients. Three scales, Schizophrenia Quality of Life Scale (SQLS), Self-rating Scale of Systemic Family (SSFD), and Stigma Scale for Mental Illness (SSMI), were, respectively, used to evaluate three variables: QoL, family dynamics, and stigma. The correlations between each factor in these three scales were evaluated by Spearman's rank correlation analysis. A mediation model was constructed to investigate whether QoL mediated the relationship between stigma and family dynamics.

Results: Correlation analysis revealed that most variables in these three scales correlated significantly with each other. Mediational regression analyses indicated that the degree of stigma was affected by family dynamics; that is, good family dynamics predicted less stigma. Surprisingly, we found that a worse QoL was associated with less stigma, and this led to good family dynamics being related to a worse QoL. These findings further suggested that QoL had a mediating effect on the relationship between family dynamics and stigma.

Conclusions: This study suggested that more attention should be focused on the multifactorial influence of stigma on patients with schizophrenia. Integrated and personalized interventions regarding QoL and family dynamics can be tailored for patients with schizophrenia to reduce self-stigma.
Correlates and Predictors of PTSD Symptoms Among Healthcare Workers During the COVID-19 Pandemic: Results of the egePan-VOICE Study
Authors: Steudte-Schmiedgen Susann , Stieler Lisa , Erim Yesim , Morawa Eva , Geiser Franziska , Beschoner Petra , Jerg-Bretzke Lucia , Albus Christian , Hiebel Nina , Weidner Kerstin
Published: August 2021

Background: The COVID-19 pandemic has led to ongoing challenges for healthcare systems across the world. Previous research has provided evidence for an increased prevalence of depression and anxiety as well as post-traumatic stress disorder (PTSD). In Germany, however, only scarce data on correlates and predictors for PTSD symptomatology in the context of the COVID-19 pandemic among healthcare workers (HCW) are available.

Methods: This research is part of a large prospective web-based survey (egePan-VOICE study) among HCW in Germany. The current sample (N = 4,724) consisted of physicians (n = 1,575), nurses (n = 1,277), medical technical assistants (MTA, n = 1,662), and psychologists (n = 210). PTSD symptomatology was measured using the abbreviated version of the Impact of Event Scale (IES-6). In addition, sociodemographic, occupational, COVID-19-related, psychological (e.g., depressive symptoms and generalized anxiety), as well as work-related variables were assessed.

Results: Our findings revealed significant higher PTSD symptoms with medium effect sizes among HCW reporting an increased self-report burden during the pandemic, increased fear of becoming infected or infecting relatives with the virus, sleep problems, feeling physically or mentally exhausted, as well as increased levels of depressiveness and generalized anxiety. According to multiple linear regression analysis, the most relevant predictors for higher IES-6 scores were increased level of generalized anxiety and depressiveness, increased fear of infecting relatives, as well as medical profession (MTA compared to physicians).

Conclusion: Despite the cross-sectional design of our study, the here identified associations with PTSD symptomatology may provide a basis for future preventive interventions.
Daily Social Life of Older Adults and Vulnerabilities During the COVID-19 Pandemic
Authors: Chen Jen-Hao
Published: August 2021

Introduction: The social integration of older adults is crucial for understanding their risk of infection and mental health during the COVID-19 pandemic. However, the social lives of older adults differ, which means they are not all vulnerable to COVID-19 in the same way. This study analyzes everyday time use and social contacts of older adults to inform discussions of their vulnerabilities during the pandemic.

Methods: Using the 2019 American time use survey (N = 4,256, aged 55 and older), hurdle model regressions were used to examine the relationship between age, gender, and six indicators of the degree of social contact and time use, including (1) time alone, (2) time spent with family members, (3) time spent with non-family members, (4) time spent with people in the same household, (5) number of public spaces visited, and (6) time spent in public spaces.

Results: Results showed substantial heterogeneity in everyday time use and social contacts. Time in public places gradually decreased from the oldest-old (85 years or older), old-old (75–84 years), to mid-life (55–64 years) adults. The gaps were not explained by age differences in sociodemographic characteristics and social roles. Compared with mid-life adults, time with family members of the young-old and old-old adults decreased, but time with non-family members increased. Age differences in social roles over the life course partially explained the differences.

Conclusions: Should these patterns of time use and social contacts persist during COVID-19; then, such variations in the organization of social life may create different exposure contexts and vulnerabilities to social distancing measures among older adults; such information could help inform interventions to better protect this population.
Pore-Scale Dynamics of Liquid CO2–Water Displacement in 2D Axisymmetric Porous Micromodels Under Strong Drainage and Weak Imbibition Conditions: High-Speed μPIV Measurements
Authors: Li Yaofa , Blois Gianluca , Kazemifar Farzan , Molla Razin S. , Christensen Kenneth T.
Published: August 2021

Resolving pore-scale transient flow dynamics is crucial to understanding the physics underlying multiphase flow in porous media and informing large-scale predictive models. Surface properties of the porous matrix play an important role in controlling such physics, yet interfacial mechanisms remain poorly understood, in part due to a lack of direct observations. This study reports on an experimental investigation of the pore-scale flow dynamics of liquid CO2 and water in two-dimensional (2D) circular porous micromodels with different surface characteristics employing high-speed microscopic particle image velocimetry (μPIV). The design of the micromodel minimized side boundary effects due to the limited size of the domain. The high-speed μPIV technique resolved the spatial and temporal dynamics of multiphase flow of CO2 and water under reservoir-relevant conditions, for both drainage and imbibition scenarios. When CO2 displaced water in a hydrophilic micromodel (i.e., drainage), unstable capillary fingering occurred and the pore flow was dominated by successive pore-scale burst events (i.e., Haines jumps). When the same experiment was repeated in a nearly neutral wetting micromodel (i.e., weak imbibition), flow instability and fluctuations were virtually eliminated, leading to a more compact displacement pattern. Energy balance analysis indicates that the conversion efficiency between surface energy and external work is less than 30%, and that kinetic energy is a disproportionately smaller contributor to the energy budget. This is true even during a Haines jump event, which induces velocities typically two orders of magnitude higher than the bulk velocity. These novel measurements further enabled direct observations of the meniscus displacement, revealing a significant alteration of the pore filling mechanisms during drainage and imbibition. While the former typically featured burst events, which often occur only at one of the several throats connecting a pore, the latter is typically dominated by a cooperative filling mechanism involving simultaneous invasion of a pore from multiple throats. This cooperative filling mechanism leads to merging of two interfaces and releases surface energy, causing instantaneous high-speed events that are similar, yet fundamentally different from, burst events. Finally, pore-scale velocity fields were statistically analyzed to provide a quantitative measure of the role of capillary effects in these pore flows.
Hill Runner's Physiology, Performance and Nutrition: A Descriptive Study
Authors: Lember Liivia-Mari , Di Virgilio Thomas George , Brown Eilidh MacKenzie , Rodriguez-Sanchez Nidia
Published: August 2021

Objectives: The aim of this descriptive study was to characterise anthropometric variables, aerobic capacity, running performance and energy intake and expenditure of hill runners in free-living conditions, and to investigate the relationship between age, anthropometric variables, aerobic capacity and running performance.

Methods: Twenty-eight hill runners participated in this study (17 males and 11 females; aged 18–65 years). Body fat percentage estimate, sum of eight skinfolds (triceps, subscapular, biceps, iliac crest, supraspinale, abdominal, front thigh and medial calf) and maximal oxygen capacity (VO2max) were assessed in a laboratory setting. Participants also completed a timed hill run (Dumyat Hill, Scotland, ascent: 420 m, distance: 8 km) while wearing a portable gas analyzer to assess oxygen consumption (VO2). Energy intake and energy expenditure were assessed in free-living conditions over three consecutive days different from the testing days through self-reported food diaries and accelerometers.

Results: VO2max assessed in the lab (51.2 ± 7.6 ml·min−1·kg−1) showed a weak negative relationship with age [rs(23) = −0.38, p = 0.08]. Neither body fat percentage (median 12.4; IQR 10.1–17.1) nor the sum of skinfolds (median 81.8; IQR 62.4–97.8 mm) correlated with age [rs(28) = 0.001, p = 0.10 and 26 rs(28) = −0.02, p = 0.94, respectively]. The observed intensity of the hill run was 89 ± 6% of the age predicted maximum heart rate and 87 ± 9% of the VO2max observed in the lab. Hill running performance correlated with VO2max [r(21) = 0.76, p < 0.001], age [rs(26) = −0.44, p = 0.02] and with estimated body fat percentage and sum of skinfolds [rs(26) = −0.66, p < 0.001 and rs(26) = −0.49, p = 0.01, respectively]. Energy intake negatively correlated with age [rs(26) = −0.43, p = 0.03], with the overall energy intake being significantly lower than the total energy expenditure (2273 ± 550 vs. 2879 ± 510 kcal·day−1; p < 0.001; d = 1.05).

Conclusion: This study demonstrated that hill running performance is positively associated with greater aerobic capacity and negatively associated with increases in adiposity and age. Further, the study highlights that hill runners are at risk of negative energy balance.
Hip Joint Kinematic Covariation During Gait Before and 1-Year After Hip Arthroscopic Surgery for Femoroacetabular Impingement Syndrome
Authors: Malloy Philip , Dr. Neumann Donald , Leung Anne , Kipp Kristof
Published: August 2021

The primary aim of this study was to determine if the three-dimensional (3D) hip joint motion coordination during gait changes after arthroscopic surgery for femoroacetabular impingement syndrome (FAIS). Three-dimensional hip joint kinematic data were collected with a 12-camera motion capture system. Five trials of level walking were collected preoperatively (PRE) and at 1-year postoperatively (POST) in 8 patients diagnosed with FAIS and at a single time point in 8 healthy controls. Planar covariation analysis was performed to quantify the 3D hip joint motion coordination strategy during gait. Independent sample's t-test were used to determine differences between the FAIS group at the preoperative time point (PRE) and healthy controls. Paired samples t-tests were used to determine differences between the PRE and POST time points within the FAIS group. The %VAF by PC 1 for the FAIS group at the PRE time point was significantly less than that of healthy controls (PRE: 77.2 ± 8.7% vs. Control: 96.1 ± 2.8%; p = 0.0001), and the % VAF of the second PC (PC2) was significantly greater [PRE: 22.8 (8.7)%; Control: 3.9 (2.8)%; p = 0.0001]. No differences in %VAF were found between the PRE and POST time points within the FAIS group for PC1 [PRE: 77.2 (8.7)% vs. POST: 79.3 (11.1)%; p = 0.472] or PC2 [PRE: 22.7 (8.7)%; POST: 20.7 (11.1)%; p = 0.472]. Significant differences in the plane specific contribution to the 3D motion coordination strategy were found between the FAIS patients at the PRE and POST time points for the sagittal plane [PRE: 5.6 (2.7) vs. POST: 0.91 (6.1); p = 0.012] and frontal plane [PRE: −10.4 (2.2) and −1.5 (6.3); p = 0.005]. Patients with FAIS demonstrated a more complex coordination strategy of 3D hip joint motion than controls and this strategy remains unchanged after hip arthroscopic surgery despite changes in the plane specific contribution to this strategy. These findings indicate that motor control impairments in FAIS patients do exist and seem to persist for at least 1 year after hip arthroscopic surgery.
A Comparison of Two-Dimensional and Three-Dimensional Techniques for Kinematic Analysis of the Sagittal Motion of Sheep Hindlimbs During Walking on a Treadmill
Authors: Diogo Camila Cardoso , Camassa José Arthur , Fonseca Bárbara , Maltez da Costa Luís , Pereira José Eduardo , Filipe Vítor , Couto Pedro Alexandre , Raimondo Stefania , Armada-da-Silva Paulo A. , Maurício Ana Colette , Varejão Artur S. P.
Published: August 2021

Compared to rodents, sheep offer several attractive features as an experimental model for testing different medical and surgical interventions related to pathological gait caused by neurological diseases and injuries. To use sheep for development of novel treatment strategies in the field of neuroscience, it is key to establish the relevant kinematic features of locomotion in this species. To use sheep for development of novel treatment strategies in the field of neuroscience, it is crucial to understand fundamental baseline characteristics of locomotion in this species. Despite their relevance for medical research, little is known about the locomotion in the ovine model, and next to nothing about the three-dimensional (3D) kinematics of the hindlimb. This study is the first to perform and compare two-dimensional (2D) and 3D hindlimb kinematics of the sagittal motion during treadmill walking in the ovine model. Our results show that the most significant differences took place throughout the swing phase of the gait cycle were for the distal joints, ankle and metatarsophalangeal joint, whereas the hip and knee joints were much less affected. The results provide evidence of the inadequacy of a 2D approach to the computation of joint kinematics in clinically normal sheep during treadmill walking when the interest is centered on the hoof's joints. The findings from the present investigation are likely to be useful for an accurate, quantitative and objective assessment of functionally altered gait and its underlying neuronal mechanisms and biomechanical consequences.