bluuebunny/crossref_metadata_2025 huggingface dataset:
NEGOTIATIONS ON THE CONCLUSION OF AN ASSOCIATION AGREEMENT BETWEEN THE EU AND MERCOSUR (1999–2023)
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Fechko Ivan
Published: May 2024

The article analyzes the negotiations on the conclusion of the association agreement between the EU and Mercosur. The stages of negotiations are defined, starting with the prerequisites for the start of this process (signing in 1995 of the Interregional Framework Cooperation Agreement between the EU and Mercosur), the official start of negotiations in 1999, the results of the main bilateral meetings of representatives of both sides, the resumption of the negotiation process in 2010, 2019, and 2023. The influence of the summits of the heads of state of the European Union and Latin America and the Caribbean, domestic and foreign political circumstances on this process is determined. In the course of the study, it was concluded that negotiations on the conclusion of an association agreement between the EU and Mercosur have become a key issue in the development of relations between the two regional integration associations and an important part of the EU’s foreign policy strategy in Latin America. The prospects for further development of the negotiation process were also analyzed in view of the recent failures to complete the signing of the agreement in 2023 and the current situation in both blocs at the beginning of 2024. Positive factors that influenced the attainment of certain milestones in the negotiation process were identified, such as the leadership role of the Iberian states – Spain and Portugal, which advocated negotiations due to their special linguistic, cultural, historical, and business ties with Latin America. Important stimuli included the summits of the countries of Latin America, the Caribbean, and the EU. Despite the lengthy negotiation process, the agreement was not signed due to resistance from the agrarian lobby in the countries of the European Union, the absence of a common EU strategy for Latin America, and domestic political issues in the Mercosur countries.
Witness’s oath as a way to Counter Deliberately False Testimony in Civil Cases: Pro et Contra
Authors: Tombulova E. G.
Published: May 2024

The paper examines the use of the witness oath in Russian civil proceedings. The purpose of the paper is to theoretically substantiate the use of the witness oath in Russian civil proceedings as a way to counter deliberately false testimony of witnesses in civil cases. The author examines historical aspects of the judicial oath, as well as comparative legal aspects of the use of the witness oath in civil proceedings in some other countries, namely, the Republic of Turkey, the Republic of Uzbekistan. The first step towards eliminating the religious content of the judicial oath was taken in the modern period in Russian constitutional court proceedings. However, the normative text of the oath does not take into account a number of socio-psychological factors. It is concluded that it is advisable to introduce an oath into civil proceedings, and not an oath of a witness, since historically the judicial oath has always had a religious content. The author analyzes legally and psychologically justified approaches to the normative text of the judicial oath and proposes appropriate changes in civil procedural legislation. In part 2 of Article 177 of the Civil Procedure Code of the Russian Federation, according to the author, it is necessary to fix the obligation of a witness to pronounce an oath before interrogation in court, as well as the normative text of such an oath: «In the face of the Russian state court, I swear on my honor to tell everything I know about the case. I promise to tell the truth, the whole truth and nothing but the truth.»
Understanding the Fundamental Nature of Crime in Criminal Law
Authors: Khilyuta V. V.
Published: May 2024

The paper examines the ontological aspects of understanding the fundamental nature of a crime and its characteristics in the doctrine of criminal law and in legislation. The crime is viewed through the prism of a single systemic concept and in connection with those features that fill its content. The author analyzes the main models and theoretical concepts that can be involved in legislative activity when constructing a generic concept of crime and characterizing its features. The emphasis is given to the fact that the main thing in formulating the essence of the crime should be the harm caused to social values. Crime is not an exclusively socially dangerous act. An act may be socially dangerous, but not criminal, because it does not carry a charge of causing harm. From this point of view, it is argued that an act that causes harm to protected values, committed by an individual is guilty and the elements of which are specified in the criminal law, should be recognized as a crime.
EU Carbon Border Adjustment Mechanism in light of the Fundamental International Environmental Treaties
Authors: Smbatyan A. S. , Saliya M. R.
Published: May 2024

On October 1, 2023, the EU has introduced a Carbon Border Adjustment Mechanism (CBAM). This is one element of the European Green Deal, a large-scale program to transform the EU’s economic policy, replete with environmental rhetoric. The question arises of how EU policies relate to the provisions of the fundamental universal international treaties in the field of combating climate change. Among all the international treaties on this issue, the UN Framework Convention on Climate Change and the Paris Agreement stand out, which, according to the EU, served as the basis for the development of the CBAM. To what extent does the Green Deal comply with the principle of common but differentiated responsibilities, does it violate the principles of fairness, non-discrimination, fair competition and other maxims — these are just some of the questions that the authors will try to answer by analyzing the package of documents establishing a fundamentally new cross-border mechanism of its kind.
Cáncer de mama en el norte del Perú: subtipos moleculares y HER2 low
Authors: Gómez-Rázuri Katherine , Abad-Licham Milagros , Astigueta Juan , Moreno Joan
Published: May 2024

El objetivo del estudio fue conocer el perfil inmunohistoquímico del cáncer de mama e identificar elsubgrupo HER2 low en la macrorregión norte del Perú. Se realizó un estudio transversal con una muestra de 1176 pacientes atendidos en el Instituto Regional de Enfermedades Neoplásicas Norte del Perú desde enero de 2016 a diciembre de 2023. Los datos recolectados (edad, tipo histológico, grado y resultados complementarios), se analizaron con frecuencias y porcentajes. El perfil correspondió a: luminal B (45,6%); luminal A (24,7%); triple negativo (18,2%); y HER2  positivo no luminal (11,5%). Además, HER2 low fueron 215 pacientes (25,1% de los considerados previamente negativos). Este estudio proporciona evidencia que la subtipificación de cáncer de mama ha cambiado, siendo luminal B más frecuente, y es esencial involucrar a políticas de salud para adquirir terapias dirigidas considerando a pacientes HER2 low.
Karakteristik Minuman Isotonik Berbahan Baku Air Kelapa (Cocos nucifera) dengan Penambahan Buah-Buahan Lokal
Authors: Satria Nur Imam , Maherawati Maherawati , Fadly Dzul
Published: May 2024

Isotonic drinks are substitutes for lost body fluids, minerals to replace electrolytes lost with sweat, and sugar as an energy source. Naturally, coconut has the potential as an isotonic drink because of its mineral composition and sugars that resemble body fluids. Coconut water isotonic drinks can be added with fruit flavors to add flavor. The isotonic drink made in this study uses coconut water combined with various local fruits (soursop, red guava, orange, kweni, belimbing wuluh, and pineapple). This study aimed to determine the characteristics of isotonic drinks made from coconut water with variations of local fruit types and the characteristics of the best isotonic drinks made from coconut water and local fruits. The parameters observed were sodium content, potassium content, pH, total dissolved solids, total acid, and antioxidant activity. The data obtained were analyzed using the ANOVA test (α=5%) and continued with Tukey (α=5%). The results showed that the characteristics of isotonic drinks made from coconut water with variations in local fruits have different characteristics according to the characteristics of each essential ingredient. Local fruit isotonic drinks have better characteristics than commercial isotonic drinks in pH value, total dissolved solids, total acid, and antioxidant activity. The isotonic drink made from coconut water with the addition of orange juice is the best isotonic drink in this study with the characteristics of sodium content 936.00 mg/kg, potassium content 398.49 mg/kg, pH value 3.75, TPT value 6.40°Brix, antioxidant activity was 88.50%, and the total acid value was 0.146%.
Pemanfaatan β-Karoten dan α-Tokoferol pada Red Palm Oil sebagai Bahan Fortifikasi Vitamin Produk Fungsional
Authors: Sidik Gusmon
Published: May 2024

Minyak sawit memiliki potensi besar untuk dimanfaatkan karena Indonesia merupakan produsen minyak sawit terbesar di dunia dengan produk akhir Crude Palm Oil (CPO) di industri hulu. Red Palm Oil (RPO) merupakan hasil pemurnian dari CPO yang mengandung karotenoid, tokoferol, dan tokotrienol. Pemanfaatan RPO sebagai minyak sawit merah belum banyak dimanfaatkan oleh masyarakat meskipun mengandung bahan-bahan yang menyehatkan bagi manusia. Review artikel ini bertujuan untuk mengetahui potensi kandungan RPO sebagai fortifying agent pada beberapa produk fungsional. Metode yang digunakan dalam review artikel ini dilakukan dengan melakukan literature review jurnal terkait fortifikasi RPO beberapa jenis produk fungsional. Hasil review artikel menunjukkan bahwa RPO berpotensi sebagai sumber vitamin A yang berasal dari kandungan β-karoten. Tambahan,
The effect of exchange rate, inflation, interest rate and import on exports in ASEAN countries
Authors: Yuliadi Imamudin , Sari Noni Pradika , Setiawati Sri Ani Puji , Ismail Syadan Hussein
Published: May 2024

Export is one sector of the economy with a major role through market expansion between several countries, where it can carry out an expansion in an industry, thereby encouraging other industries and further encouraging other sectors of the economy. This study aims to analyze the effect of exchange rates, inflation, interest rates, and imports on exports in ASEAN countries. The data used in this study were annual data for the 2015-2019 period sourced from the World Bank. This research model employed a panel data method with a fixed-effect model, combining time series and cross section data with the help of EViews 7. The results revealed that exchange rates and imports had a positive and significant effect on exports. In addition, inflation and interest rates had a positive and insignificant effect on exports. Therefore, the governments of the ASEAN countries must monitor the stability of exchange rates, inflation, interest rates, and imports to increase exports from year to year so that the economy in ASEAN countries remains stable.
Evaluation of causes of female infertility by hysteron-laparoscopy
Authors: Rani L. Jhansi , Panda Akankhya , Haripriya C.
Published: May 2024

ABSTRACT
Background: Infertility is rising in recent times affecting about 60-80 million couples worldwide. Female infertility can occur due to variety of causes, ranging from hormonal imbalance to congenital anomalies or infections or other pathologies involving uterus, fallopian tubes, ovaries, external genitalia or even error of coitus. Hystero laparoscopy with chromo perturbation is the gold standard diagnostic method in evaluation of tubal factors, uterine and peritoneal disorders. Aims and objectives were to evaluate the different causes of primary and secondary infertility in women of reproductive age using hysteron laparoscopy with chromo perturbation.
Methods: It is a prospective observational study done on 50 infertile women. Study population is divided into two groups- primary infertility and secondary infertility. Only those infertile ladies whose husbands showed normal semen analysis are included in the study. A detailed clinical history, marital, obstetric history, coital history, addiction history of the patients is taken. Thorough gynaecological examination is done and all necessary investigations is done. All infertile women and women willing to participate are included in the study. Women with male factor infertility and active genital infections are excluded.
Results: Out of 50 infertile women, 36 have primary infertility and 14 have secondary infertility. Of them 24 (48%) have normal findings. Ten (20%) women have unilateral tubal blockage, 4 (8%) women had bilateral tubal blockage, 8 (16%) women have adhesions between ovaries, tubes, uterus and surrounding structures and 4 (8%) women have polycystic ovaries.
Conclusions: Hystero laparoscopy proved to be an important tool in diagnosing the different causes of female infertility.
Sequential use of oral and vaginal misoprostol versus oral or vaginal misoprostol alone for induction of labor and the caesarean delivery risk: a retrospective study
Authors: George Anu Anna , Francis Amala Rita , Zachariah Pavithra Sosa , Isac Mini
Published: May 2024

Background: Induction of labor is now a common practice and every institute faces the task of developing a safe and cost-effective protocol. We aimed to study the effects of sequential use of oral and vaginal misoprostol when compared to oral or vaginal misoprostol alone. Our primary objective was to determine the caesarean delivery rates and secondarily the maternal and neonatal complications between the different induction regimes.
Methods: A single-center retrospective observational study was conducted, with patient records divided into three groups based on their methods of induction: those who were administered vaginal misoprostol only, those who had oral misoprostol only, and those who had oral misoprostol followed by vaginal misoprostol. We extracted all the necessary data from the records and analyzed it using SPSS.
Results: 768 records with comparable demographic characteristics were reviewed. The majority of women were induced at 39 completed weeks. There was no significant difference in the proportion of caesarean deliveries when comparing the three groups but the number of caesarean sections was lower among women who had been administered vaginal misoprostol alone. Among the patients included in the study, the women who developed postpartum hemorrhage received a higher mean dose of misoprostol (130±70 mcg) compared to those who did not (104±57 mcg).
Conclusions: Sequentially administering misoprostol may not decrease the caesarean section rate compared to using only one route of administration. However, it is important to monitor the amount of misoprostol given to each patient to prevent the incidence of PPH.
A case report of methemoglobinemia in pregnancy
Authors: Gupta Jyotika , Patel Sejal , Parmar Yogesh
Published: May 2024

Methemoglobinemia is a rare form of functional anaemia which disrupts the ability to transport oxygen effectively by the haemoglobin leading to obstetrical as well as non-obstetrical complications. Our objective was to observe the antenatal, perinatal, and post-natal outcomes in women diagnosed with methemoglobinemia. A case report of two patients of methemoglobinemia admitted in a tertiary care centre of South Gujarat. The report displays a qualitative analysis of the diagnosis and management undertaken, providing a critical evaluation of their effectiveness and implications for future clinical practice. Methemoglobinemia, while uncommon, requires awareness for timely diagnosis and effective management. Congenital cases often go unnoticed until pregnancy, with methaemoglobin levels under 20% usually not necessitating treatment. Symptomatic individuals can benefit from methylene blue and hyperbaric oxygen therapies. Avoiding certain drugs and ensuring swift diagnosis, coupled with proper counselling, can lead to favourable pregnancy outcomes.
Incidence of urinary tract infection in surgical patients after short term catheterization in a tertiary care institute
Authors: Bagree Rajendra , Srinivas Vinay , Kumar Ritesh , Gupta Ayush , Kumar Naveen , Kumar Nitish
Published: May 2024

Background: We aim to assess the rate of catheter associated urinary tract infection in patients undergoing catheterization in our surgical ward. Urinary catheters pose a potential risk of introducing infections in the urinary system. We observed the setting of catheterization and incidence of UTIs, prevalence, contributing factors, and potential preventive measures. We aim to enhance the quality of patient care and reduce the burden of post-catheterization complications.
Methods: The research methodology involves a retrospective analysis of patient records, encompassing a large sample size from the tertiary care institute. Data collection includes patient demographics, duration of catheterization, underlying health conditions, and microbial profiles. Statistical analyses will be employed to discern patterns, risk factors, and correlations.
Results: 322 patients admitted in our surgical ward were catheterized as a part of this study, out of which 170 patients came under the inclusion criteria, including 63 males and 107 females. It was found that 19 patients, 13 female and 6 males, had developed positive urine cultures on day 3 of catheterization, with 6 patients showing symptoms of UTI. 14 out of 19 cultures were positive for E. coli, 3 for Klebsiella sp., 1 for Citrobacter spp. And 1 for E. gallinarum.
Conclusions: In this study, we concluded that maximum cases of CAUTI were due to inappropriate catheterization in emergency surgical procedures, where proper aseptic standards were not applied. Preventive strategies should be applied to minimize the incidence and complications of CAUTI.
Rectus sheath hematoma in post-lower segment caesarean section patient
Authors: Kamboj Sunaina , Pal Naresh , Arora Bhavinder Kumar
Published: May 2024

Rectus sheath hematoma is a rather uncommon and often misdiagnosed clinical condition, usually follows abdominal trauma and anticoagulation. The daily activities of patient like sitting and lying in the bed produced the trauma which led to formation of hematoma. This trauma led to tear of inferior epigastric artery, which started bleeding with in the rectus sheath leading to formation of a big hematoma. Exploratory laparotomy was done. A hematoma of size 5×6 cm was visualized between anterior rectus sheath and rectus muscle on right side. Rectus muscle hematoma is due to shearing force to the inferior epigastric vessels due to routine activity of the patient.
Analytical Method Development, Validation, and Estimation of Lupeol, Quercetin, Vasicine in Polyherbal Formulations and Selected Plant Species by using UFLC-MS
Authors: Jatoth Ramkishan , Dhanabal S. P. , Kalakotla Shankar , Senthil V. , Ganesh T. , Jeyprakash M. R. , Selvaraj Jubie
Published: May 2024

Background: Kabusura kudineer (KSK) is a marketed Siddha-based polyherbal formulation, and on the authority of the Govt of India, the Ministry of Ayush recommended Kabusura kudineer in the therapy of COVID-19, and due to its immuno-booster effects. Based on the “Kabusura kudineer” (KSK) formulations, we developed a “Hydaljss08” polyherbal formulation composed of 16 dried crude materials and 03 fresh forms. Both formulations contain active phytopharmaceuticals such as vasicine, quercetin, and lupeol and these are responsible for anti-viral and immunomodulatory effects, which may be due to their synergistic and additive effects. The chemical nature of vasicine is an alkaloid, quercetin is a flavonoid, and lupeol is a pentacyclic triterpenoid. Aim: The current study aims to develop and validate the analytical process for assessing vasicine, quercetin, and lupeol in both dosage forms and in a selected plant species by UFLC-MS. Methods: The ultrafast liquid chromatography study was designed by the columns of Inertsil C8, and Inertsil C18, individually, for vasicine, quercetin, and lupeol respectively. The columns and mobile phase were used as a water C18, 20 mM phosphate buffer pH 2.5: acetonitrile in a combined UFLC method development of vasicine, quercetin, and lupeol. Results: A calibration curve and adequate linearity were recorded for vasicine, quercetin, and lupeol by injecting 20.0-60.0 μg/ml, 50.0-150.0 μg/ml, and 25.0-75.0 μg/ml of marker substances. The LOD, and LOQ of the vasicine, quercetin, and lupeol were found to be 1.19, 3.60, 3.80, 11.51, 1.79, and 5.41 μg/ml, and the Ruggedness value of vasicine, lupeol, and quercetin was found in % RSD 0.4%, 0.1%, and 0.1%. Conclusion: The developed and validated method showed good linearity with a range of correlation coefficients, new, simple, novel, accurate, specificity, precision, robustness, and ruggedness are within the limits.
Ayurvedic Management of Hepatocellular Jaundice – A Case Report
Authors: Yadav Pankaj , Kuchewar Vaishali , Yadav Tanika , Chhabra Aman
Published: May 2024

Jaundice is a yellow discolouration of the skin, another mucous membrane and the conjunctival membrane surrounding the sclera. It is a clinical symptom of either underlying hepatocellular dysfunction biliary obstruction or anomalies of bilirubin metabolism. This clinical entity can be compared with Kamla as described in Ayurveda. The strength of Ayurveda in treating jaundice should be emphasised. This is a case report of a 24-year-old male patient who visited Kayachikitsa out-patient department with the chief complaints of Agnimandya (reduced appetite), Chardi (vomiting), Udarashool (pain in the abdomen), Hrullas (nausea), Peet varniya Netra (yellow discolouration of eyes), Daurbalya (lassitude), Vibhandha (constipation) for seven days. The patient was effectively treated with mild shodhana (bio-purification) with Nitya virechana (purgation therapy) followed by medicinal treatment for 30 days. After 4-5 days, there was a significant improvement in all clinical features and a substantial improvement in liver function. The treatment was given by considering the vitiation of Pitta and Rakta. It can be concluded that this disease was managed and liver functions were improved by ayurvedic management.
Effectiveness of Varmam Therapy and Kombarakku Ottradam in the Management of Thandagavatham (Lumbar Retrolistihesis) - A Case Report
Authors: Kavitha K. , Bhagyalakshmi B. , Ramya V. , Samundeswari P. , Muthukumar N. J. , Mahalakshmi V.
Published: May 2024

The Siddha system of medicine is one of the classical Tamil systems of medicine. According to this system of medicine, Thandagavatham is one of the Vaatha diseases with the clinical features of pain in the lumbar region and para-spinal region. This condition may be correlated to lumbar retrolisthesis. A case report of Thandaga vatham (lumbar retrolisthesis) was documented for publication. A male patient of 19 years had suffered pain in the lower back and right sacroiliac region radiating to the right thigh. He could not walk for long distances, sit for a prolonged time and lie on his right lateral position for more than 6 months. He came for Siddha treatment in Varma Maruthuvam OPD of Ayothidoss Pandithar Hospital (APH), National Institute of Siddha. He had a history of allopathic treatment for this condition. Modern medicine management available for lumbar retrolisthesis is physiotherapy and the severe cases need surgery. In this clinical study, the patient was managed with Varmam therapy and Kombarakku Ottradamin at the Varmam Department of the National Institute of Siddha, Chennai. The patient was treated for 48 days and had decreased pain and a limited range of motion was evaluated clinically by using the Oswestry low back pain scale.
Conceptual Study of Urdhvaga Amlapitta (Hyperacidity) and its Ayurvedic Management by Vasa Ghrita
Authors: Yadav Deepak , Borkar Preeti , Ravekar Dhanashree , Joshi Dnyanesh , Khaire Utkarsha
Published: May 2024

Background: The three basic pillars which help in the understanding of disease symptoms and its management are called Trisutra. These have three components, Hetu as causative factors, Linga, as specific symptoms and Aushadha as drug and management of disease. Methods: The study was carried out at the Mahatma Gandhi Ayurved College Hospital and Research Centre, Salod, Wardha. A total of 60 patients of Urdhavag Amlapitta were registered for the present research work. Results: In this study, all the patients reported with imbalance of Tridosha. In this study, a significant time-dependent therapeutic response was reported, and after the treatment significant improvement was reported in the disease symptoms. Conclusion: After observing the symptoms before and after treatment we can say that Vasa Ghrita can be a much better remedy for Urdhvag Amlapitta (Hyperacidity).
Exploring the Potential of Traditional Herbal Plants in the Management of Diabetes Mellitus: A Comprehensive Investigation
Authors: . Sanskriti , Mazumder Avijit , Bansal Priyanka , Pentela Bhavani , Tyagi Pankaj Kumar , Khurana Navneet
Published: May 2024

Diabetes Mellitus (DM) is one of the most prevalent chronic conditions bearing considerable social, health, and economic ramifications. Uncontrolled DM manifests secondary complications such as foot ulceration, retinopathy, neuropathy, nephropathy, and cardiomyopathy. The heterogeneity inherent in DM necessitates a comprehensive therapeutic strategy that is equally safe and effective against multifaceted diseases like DM. Conventionally, DM management relies on lifestyle modifications and dietary adjustments, complemented by pharmacological interventions. However, the limitations associated with oral hypoglycaemic agents prompt an exploration of alternative modalities. These days, substantial resources within healthcare are dedicated to investigating traditional systems of medicine, notably Ayurveda and traditional Chinese medicine, seeking novel interventions for DM management. This systematic review aims to evaluate the available literature of 2017-2023, focusing on identifying herbs with potential efficacy in DM management with their potent mechanism of action. By synthesizing current scientific knowledge, the review elucidates the intricate molecular-level mechanisms of action of medicinal plants in DM. This contribution enriches the scientific discourse by providing a comprehensive resource for the nuanced exploration of innovative approaches to address the complex facets of DM. As healthcare endeavours to diversify its strategies, the insights from this review may pave the way for developing novel and effective interventions for managing DM using medicinal plants.
Exploring Natural Product Derivatives having Carbonic Anhydrase Inhibitory Activity
Authors: Packiapalavesam Shakthi Devi , Saravanan Venkatesan , Ramesh Pavithra , Devarajan Agilandeswari , Mohan Maruga Raja Muthu Kumaradoss , Kathiravan Muthu Kumaradoss
Published: May 2024

Carbonic anhydrase is an enzyme which plays an active role in many biological functions of the human body. It is omnipresent in all the biological organisms with eight different genetic families. Its primary role is to catalyze the reversible hydration of CO2 to bicarbonate and protons. Though it is beneficial in many aspects it is also equally important for the cancer cells because of its pH regulatory nature. For tumor cells to survive and metastasis the regulation of pH and creating a hypoxia condition is very much needed, as Carbonic anhydrase is an extended family of sixteen isozymes, some of them are very essential for tumor cells. Many research is going on to inhibit the selective enzyme which is over expressed in the tumor cells. To be exact Carbonic anhydrase IX and XII are the most important enzymes overexpressed in the tumor cells. Sulfonamides, along with their bioisosters sulfonamides and sulfamates, have been employed for decades in treating conditions like glaucoma, epilepsy, and diuretics. Notably, this class of compounds has been extensively studied for its role as carbonic anhydrase inhibitors, showcasing their significant use and exploration in various therapeutic applications. In recent years, there has been a notable shift in the study of Carbonic anhydrase inhibitors  towards natural products in addition to synthetic derivatives. Traditional drug design methods have historically yielded synthetic CAIs, but the exploration of Natural products derivatives has significantly advanced the field. Natural products, such as psammaplin C and altemicidin, containing primary sulfonamide or sulfamate groups, are gaining attention. The chemical diversity, binding specificity, and interaction tendencies of natural product derivatives make them appealing for molecular probes in research.
The Effect of UEFA Club Competitions on the Local Hospitality Performance
Authors: Chalupa Stepan , Kocourek Martin , Bielikova Hana , Petricek Martin
Published: May 2024

Sports events significantly affect the hosting destination and the interest in its visiting. Previous studies focused mainly on longitudinal events like the Olympic Games and FIFA World Cups, where the single-day events were not investigated. The paper investigates how hosting UEFA competition finals affects the local hospitality industry's performance. The study adopted the benchmarking data from Smith Travel Research (STR) and evaluated the impact on the occupancy and prices of accommodation facilities. The results show a significant pricing effect for the day of the event and the day before the finals. There was increased demand when focusing on the occupancy rate, but not as significant as for the prices. No long-term effect on the hospitality industry was identified, and, in some cases, the negative effect might be perceived after the event's termination. To benefit from the event with significant interest from football fans, hoteliers should increase the sales rates, provide the guests with a broader range of services, and cooperate with the event organisers to increase the total performance.
Students' Ability to Formulate Situation Mathematically from Context-Based Mathematics Problems
Authors: Sa’diyah Mukhtamilatus , Sa’dijah Cholis , Susiswo Susiswo
Published: May 2024

Mathematical literacy has become one of the new standards for students' understanding. To be able to develop suitable problem-solving strategies, especially context-based problems, students need to have the ability to formulate situations mathematically well. This research was conducted to observe students' abilities in formulating situations mathematically. The research subjects were students aged 14-16 years in Malang City in February 2023. This research was qualitative research. The data collected was students’ answers on context-based mathematical problems from the Program for International Student Assessment (PISA) whose questions are related to activities of formulating situations mathematically. Result showed that the majority of students did not have sufficient ability and experience in formulating situations mathematically, both in terms of understanding the context of the problem, determining variables, and developing problem-solving strategies. This means that many students still have difficulty determining procedures for solving PISA problems, especially context-based ones. Teachers need to provide more learning and familiarization regarding the process of formulating situations mathematically to make it easier for students to solve context-based mathematical problems.
Professor Alexander Pisarchik: scientific achievements and 70 years of productive activity
Authors:   Immanuel Kant Baltic Federal University, Hramov Aleksandr
Published: May 2024

3 June 2024 marks the 70th birthday of Alexander Nikolayevich Pisarchik, a brilliant researcher of international renown in the field of laser physics, nonlinear dynamics and its applications in brain sciences.
Types of cycles symmetry in coupled period doubling systems
Authors:   Saratov Branch of Kotel`nikov Institute of Radiophysics and Electronics of Russian Academy of Sciences, Seleznev Evgeny , Dudova Anastasiia ,   Saratov State University
Published: May 2024

Types of symmetry of various cycles and their evolution in coupled period doubling systems are discussed. Full symmetry leads to formation of new scenario transition to chaos. It is shown that at driven loss of full symmetry for several cycles local symmetry takes place. As well as full symmetry cycles the local one demonstrates quasiperiodic route to chaos.
Dynamical systems of different classes as models of the kicked non-linear oscillator
Authors:   Saratov Branch of Kotel`nikov Institute of Radiophysics and Electronics of Russian Academy of Sciences, Kuznetsov Aleksandr , Turukina Ludmila ,   Saratov State University
Published: May 2024

Correspondence between the models as dynamical systems of different classes is discussed by the example of nonlinear dissipative kicked oscillator. 1D map is investigated in details: Feigenbaum’s period doubling is studied and the possibility of non—Feigenbaum’s period doubling is shown, corresponding illustration in the form of bifurcation diagrams and set of iteration diagrams are given, tricritical points (terminal points of the Feigenbaum’s critical curves) are found in parameter space. The correlation with the properties of 2D map, the phenomenon of tricritically dynamics was demonstrated to take place only on definite areas of the parameter space.
Optical chaos in a single-mode frequency-stabilized laser
Authors:   Saratov State University, Akchurin Garif , Akchurin Alexandr ,   Saratov State University
Published: May 2024

Scenario of transition from stationary state to regime of generation with irregular pulsations of output optical power is explored. which can arise in a single—mode laser with active system of frequency siabilization. Particularities of transition to dynamic chaos mode are explored. depending оп such control parameters as a feedback gain factor, ratio of laser gain to loss. ratio оf homogeneous line widih to Doppler’s one. Possibility of chaotic behaviour arising in lasers with nonlinear—absorbin cell is shown. on the basis of which international standards of length аге realized.
On some properties of the Frobenius - Perron operator for the Bernoulli shifts
Authors:   Saratov State University, Golubencev Aleksandr , Anikin Valerij ,   Saratov State University, Arkadaksky Sergej ,   Saratov State University
Published: May 2024

The expansion of solutions of Frobenius — Perron equations of the Bernoulli shifts and conjugate maps in terms of the eigenfunctions of the same name operators are presented. The convergence of nonstationary solutions to the invariant density is discussed. it is marked that the Lyapunov exponent may be considered as a measure of the speed of convergence. The entire function as an element of Frobenius — Perron operator kernel is found.
Collaborative Governance in Forest and Land Fire Control Policies in Ogan Komering Ilir Regency
Authors: Tomiyansyah Ardhi
Published: May 2024

The government has carried out collaborations with the private sector and the public, but the fires remain or has not been able to be minimized. This research aims to analyze how the governance is collaborative in forest and land fire control policy in Ogan Komering Ilir Regency. The collaborative governance theory used is the Donahue and Zeckhauser theories. The analysis in this research is collaboration in the sense of a process, starting from the initial condition, establishing collaboration, and designing collaboration. It is closely related to the process of policymaking and policy analysis, that is, from agenda formulation to policy formulation to policy adoption. The research design uses qualitative descriptive research, with research informants from government and private elements. Based on the results of the research and findings in the field related to collaboration relationships, collaboration carried out between government, private, and public has various shortcomings, such as less active collaboration, compliance in nature, and unstable stability in its cooperation. There is a tendency for some non-governmental parties who want discretion of profit preference, so collaboration as a whole possess risks, namely reputational and dependence on the private.
Keywords: collaborative governance, policy, forest and land fire control system
Bibliometric Analysis: Publication Trends of Forest and Land Fire Policy 1969-2024
Authors: Vahlevi Ahmet , Putri Aulia Utami , Mawardika Indah
Published: May 2024

This study aims to analyze publication trends related to the themes of Butane and land fire policies indexed in the Scopus database from 1969 to 2024. Journal articles in the field of forest and land fire policy published between 1969 and 2024 are traced from the Scopus database using the keywords “Forest Fires” OR “Land Fires” AND “Policy”. This study uses analysis of publication trends forest and land fire policy, most productive countries and most productive organizations, co-authorship, co- and citation. Research on forest and land fire policy is widely conducted around the world. This is because many problems must be solved by multistakeholders. Publications in 2022 became the most productive year with 215 publications. The United States and Spain are the two countries that are most productive in producing publications related to forest and land fire policies. The network of co-authorship based on documents is Stephens, SL being the most common. Co-Occurrence networks for Author Keywords include forest fires, deforestation, forest management, wildfire, remote sensing, wildfires, landsat, protected areas. Bibliometric methods can be used to analyze publication trends related to “forest and land fire policy”. However, it needs the support of datasets and a complete computing system. The results of the analysis of forest and land fire policy articles show an increase in publication trends related to forest and land fire policies.
Keywords: bibliometric analysis, policy implementation, land fires, forest
Aproximación a la valoración económica de los servicios ecosistémicos prestados por el humedal Las Tinguas
Authors: Riaño Morales Daniela , Vásquez Traslaviña Laura Daniela , Cita Velandia Ángela Yolima
Published: May 2024

Colombia es un país de humedales. De acuerdo con Burbano Girón et al. (2020), el Instituto Humboldt emitió un informe en el que revela que el país cuenta con cerca de 31 millones de hectáreas de humedales, lo que representa el 26% de su territorio continental e insular, sin embargo, aproximadamente el 88% de ese territorio no dispone de protección legal, por lo que la continua pérdida de recursos naturales aumenta la vulnerabilidad de las comunidades ante eventos climáticos extremos. Por ello, el objetivo de este artículo es valorar económicamente los servicios ecosis­témicos de regulación y cultura del humedal Las Tinguas (localizado en Facatativá, Colombia) mediante las metodologías propuestas por el Ministerio de Ambiente en su guía de aplicación de la valoración económica ambiental, estas son: a) la metodología basada en los gastos actuales o potenciales mediante la indagación de la inversión pública y privada para la conservación del ecosistema; b) la meto­dología de costos inducidos a través del cálculo del costo económico causado por la pérdida de los servicios ecosistémicos, y c) la metodología de valoración con­tingente relacionada con la disponibilidad de pago de la comunidad directamente beneficiaria del humedal. Se concluye que, pese a que muchas instituciones han participado en la conservación del humedal, muy pocas han invertido recursos económicos para garantizar la estabilidad de los servicios ecosistémicos.
LEVEL OF COMPLIANCE AND SUCCESS OF THERAPY OF SIPHYLIS AT DERMATOLOGY AND VENEREOLOGY CLINIC RSUD DR. SAIFUL ANWAR MALANG: A DESCRIPTIVE STUDY
Authors: Donoseputro Intan Wasaputri , Setyowatie Lita
Published: May 2024

Syphilis is a chronic progressive sexually transmitted infection, that causes a life-threatening condition if left untreated. In lower-middle-income countries, the burden of disease might appear to be lower due to a lack of reports. This study aimed to report the epidemiological profile, the profile of compliance, and the success of therapy of syphilis at the Dermatology and Venereology Outpatient Clinic in RSUD dr. Saiful Anwar Malang, Indonesia. This study used a descriptive approach using secondary data from the medical records of newly diagnosed syphilis patients at Dermatology and Venereology Clinic RSUD dr. Saiful Anwar Malang from January 2021 - December 2021. Sample collection was using a total sampling technique. Eighteen medical records met the inclusion criteria. The majority of samples were men (77.8%), aged 17-25 years (44.4%) and 26-35 years (44.4%), had a high school education (55.6%), HIV positive (50%) and HIV negative (50%). All 18 patients got intramuscular injections of a single 2.4 million U or 7.2 million U Benzathine Penicillin G according to the syphilis stage. It was found that eight patients (44.4%) had a successful therapy, two patients (11.2%), experienced failure, and the remaining eight patients (44.4%) were unknown due to loss of follow-up. Several factors are associated with better patient compliance including older age, higher educational level, type of the disease, and lower complexity of treatment schedules. Overall, therapeutic compliance of syphilis patients is good, but monitoring compliance needs to be improved. Benzathine Penicillin G remains the drug of choice for syphilis and has a high success rate.
Comorbid Factors and Duration of Illness in Dengue Hemorrhagic Fever Patients at Universitas Airlangga Hospital, Surabaya, Indonesia
Authors: Savita Lady
Published: May 2024

Dengue hemorrhagic fever (DHF) continues to prevail in Indonesia annually. Individuals afflicted with dengue hemorrhagic fever may exhibit distinct clinical manifestations, and these can vary based on individual factors. Numerous elements can contribute to this diversity. Typically, adult patients with comorbidities face a less favorable prognosis for the primary disease. This study aimed to examine the impact of comorbid factors on the severity of DHF, as well as its duration. The comorbidities considered in this research encompassed hypertension, diabetes mellitus, and obesity. This research employed an analytical approach and was conducted at Universitas Airlangga Hospital from January to December 2022. Medical records served as the primary data source for this study. A total of 121 patient samples were collected based on specific criteria. The criteria included adults (>18 years) treated at Universitas Airlangga Hospital, who had no comorbid diseases other than those under study, and possessed complete medical record data. The sampling technique employed in this research was total sampling, which adhered to the inclusion and exclusion criteria. This research demonstrated that comorbid factors were not associated with the severity of DHF (p<0.05), while the duration of illness in DHF patients was correlated with the severity of the disease (p=0.027).
A descriptive analysis of sexual and reproductive health services for Syrian women in Türkiye provided through minimum initial service package approach
Authors: Özvarış Şevkat Bahar , Yüksel-kaptanoğlu İlknur , Erdost Türküler , Konşuk Ünlü Hande
Published: May 2024

Abstract
Objective: Sexual and reproductive health (SRH) is a priority public health emergency response for women during humanitarian crisis situations as they face the risk of being neglected in health care systems of the country of arrival. This study aimed to investigate Syrian refugee women’s utilization of SRH services, through Minimum Initial Service Package (MISP) approach, provided by a team including health mediators at Women Health Counseling Units (WHCU) established as part of a collaborative project.
Methods: Questionnaires were administered face-to-face by Arabic-speaking Turkish female interviewers to 413 Syrian women who previously received services from the WHCU. Descriptive statistics were presented and Pearson chi-square tests were conducted to analyse bivariate differences between categorical variables.
Results: Child marriages were common among more than half (%59) of the participants. Majority of deliveries took place in the public hospitals (95%) and as attended by a doctor (93%). The percentage of participants using modern contraceptive methods was found to be 39,7% who were more frequently from younger age groups. However, the withdrawal method was relatively more prevalent among older participants.
Conclusion: Incorporating the MISP approach into primary health care practices as an integral part of response efforts in humanitarian crises, is considered as a promising model for strengthening refugee women’s access to culturally and gender sensitive SRH services and contribute to fulfillment of SRH rights. Employing refugee health mediators is assessed to function as a crucial link between the refugee community and the health care system enhancing the accessibility and effectiveness of SRH services provided.

Key words: Sexual and reproductive health, MISP, refugees, Syrian women, humanitarian crises
New Method of Isolation and Deriving Cell Line from Frozen Nervous Tissue
Authors: Kubis-Kubiak Adriana , Wiatrak Benita , Piwowar Agnieszka
Published: May 2024

The extraction of cell cultures from fresh tissue is a process that requires significant computa-tional resources and is associated with substantial overheads. The objective of our research is to de-vise a rapid, straightforward, and efficient technique for the cultivation of neuronal cells derived from frozen biological material. We utilized freshly isolated hippocampus and cerebral cortex tissue from rats, in addition to whole brain tissue. This tissue underwent digestion and processing to yield a cellular suspension. This suspension was subsequently cryopreserved using a variety of cryopro-tectants: CTS™ Synth-a-Freeze™, SpermFreeze®, and a medium supplemented with 10% DMSO. CTS™ Synth-a-Freeze™ is a commercially available cryoprotectant typically employed in the preservation of cellular cultures, while the addition of 10% DMSO to the medium is a conventional technique for the cryopreservation of cells to mitigate damage. The innovative aspect of our meth-odology is the application of SpermFreeze®, a product used for the cryopreservation of sperm in in vitro clinics. We postulated that SpermFreeze® might enhance the viability and quality of the cryo-preserved neuronal cells, given the delicate and energetically demanding nature of both sperm and neuronal cells. The ultimate objective was to ascertain whether a cryoprotectant formulated for sperm could augment the post-thawing efficacy of our nervous system cells. This investigation intro-duces an innovative methodology for the optimization of neuronal cell isolation and cryopreserva-tion from animal-derived tissues.
Intertwining Between Temperature, Amount of Mixture, and Particle Number, in a Paradigmatic Many-Fermion Problem
Authors: Monteoliva Diana , Plastino Angelo , Plastino Angel Ricardo
Published: May 2024

In this study, using information theory tools, we investigate the quantum degree of mixedness, particle number fluctuations, and temperature variations in the paradigmatic Lipkin model, focusing on the interplay between these factors in a system of many fermions. Our analysis reveals intriguing dependencies of quantum mixedness on the total fermion number, showcasing distinct behaviors at different temperatures. Notably, we find that the degree of quantum mixedness exhibits a strong dependence on the total fermion number, with varying trends observed across different temperature regimes. Remarkably, this dependence remains unaffected by the strength of the fermion-fermion interaction (if it does not vanish, of course), underscoring the robustness of the observed phenomena. Through comprehensive numerical simulations, we provide illustrative graphs that depict these dependencies, offering valuable insights into the fundamental characteristics of many-fermion systems. Our findings shed light on the intricate dynamics of quantum degree of mixedness and particle number fluctuations in fermionic systems, with potential implications for diverse fields ranging from condensed matter physics to quantum information science.