bluuebunny/crossref_metadata_2025 huggingface dataset:
Coinfección de tuberculosis y candidiasis pulmonar en paciente previamente sana
Authors: Fontalvo Dilia Mildret , Jiménez Borré Gustavo , Gómez Camargo Doris , Chalavé Jiménez Neylor , Bellido Rodríguez Javier , Cuadrado Cano Bernarda , Navarro Gómez Shirley
Published: November 2019

Antecedentes:La coexistencia entre los hongos patógenos y la tuberculosis pulmonar es una condición clínica que se produce generalmente en pacientes inmunosuprimidos, sin embargo, los pacientes inmunocompetentes puede tener esta condición con menor frecuencia.Objetivo:Presentamos el caso de un paciente inmunocompetente con diagnóstico de una coinfección de tuberculosis Mycobacterium tuberculosis y Candida albicans.Caso clínico:Paciente femenina de 22 años con cuadro abrupto de tos, fiebre y hemoptisis sin antecedentes de enfermedad.Hallazgos clínicos y métodos diagnósticos:Al examen respiratorio se halló disminución del murmullo vesicular en la región apical y estertores crepitantes basales en el pulmón izquierdo. Se realizó estudios microbiológicos de muestras tomadas por expectoración y por fibrobroncoscopia en el que se incluyó la tinción de Ziehl-Neelsen, cultivo para micobacteria y hongos en medio Agar Dextrosa Sabouraud y filamentización en suero obteniéndose positividad para Mycobacterium tuberculosis y Candida albicans.Tratamiento y resultado:Se le realizó manejo con antifímicos de primera categoría y antimicóticos con buena respuesta clínica.Relevancia clínica:La coinfección fúngica y tuberculosis pulmonar no es frecuente en pacientes inmunocompetentes, debe sospecharse en episodios abruptos de hemoptisis.
Strength and ability to implement the activities of daily living in elderly resident in rural areas
Authors: Rocha Saulo Vasconcelos , Santos Samara Souza , Vasconcelos Lélia Renata Carneiro , Santos Clarice Alves
Published: November 2019

Objective:To examine the association between muscle strength and the ability to perform basic and instrumental activities of daily living in elderly resident in rural areas of Jequie, Brazil.Methods:We performed a cross-sectional design study with a population of 104 individuals aged sixty or older, registered in the Family Health Unit of the district of Itajuru, Jequie-Brazil. Data collection was performed using a standardized instrument used as an interview, followed by the application of tests (bending arm with dumbbell and rising from a chair 30 sec). The basic and instrumental activities of daily living were investigated through the Katz and Lawton scales, respectively. The chi-square test with p ≤0.05 was used as a measure of statistical significance for bivariate analyzes between muscle strength and ability to perform daily activities.Results:The results showed a significant association between muscle strength and dynamic ability to perform activities of daily living.Conclusion:Reduced muscle strength is an important predictor of the functional ability of the elderly. Accordingly, it is recommended to observe muscle strength in actions directed at the elderly.
Registro de Trauma de la Sociedad Panamericana de Trauma: Un año de experiencia en dos hospitales de en el suroccidente colombiano
Authors: Ordoñez Carlos Alberto , Morales Mónica , Rojas-Mirquez Johanna Carolina , Bonilla-Escobar Francisco Javier , Badiel Marisol , Miñán Arana Fernando , González Adolfo , Pino Luis Fernando , Uribe-Gómez Amadeus , Herrera Mario Alain , Gutiérrez-Martínez Maria Isabel , Puyana Juan Carlos , Abutanos Michael , Ivatury Rao R.
Published: November 2019

Introducción:Los sistemas de información en trauma son requeridos para mejorar la toma de decisiones e identificar potenciales áreas de intervención.Objetivo:Describir el primer año de experiencia del registro de trauma en dos centros de referencia de trauma del suroccidente Colombiano.Métodos:Estudio realizado en dos centros de referencia de Cali. Se incluyeron pacientes con trauma o lesiones externas entre el 1-Ene y el 31-Dic-2012. Se recolectó información demográfica, relacionada con mecanismos de trauma, severidad (ISS) y mortalidad. Se presenta un análisis descriptivo.Resultados:Se registraron 17,431 pacientes. El 67.8% de los pacientes eran de género masculino con edad promedio de 30 (±20) años. Las lesiones laborales fueron causa de consulta a urgencias en un 28.2%, y las caídas el mecanismo de trauma más frecuente (37.3%). Los pacientes con ISS ≥15 en su mayoría se encontraban en el rango de edad de 18-35 años (6.4%). El 28% de los pacientes que sufrieron lesión por arma de fuego presentaron un ISS ≥15. El 2.5% de los pacientes murieron y aquellos pacientes con ISS ≥15 y lesión por arma de fuego presentaron mortalidad del 54%.Conclusión:una vez se logró implementar el registro de trauma en dos instituciones en Cali, se identificó que la principal causa de ingreso fue secundaria a caídas y las lesiones laborales. Los pacientes más severamente comprometidos están en el rango de población entre 18 a 35 años. La mayor mortalidad se presentó secundario a lesiones de causa externa por arma de fuego.
Immunocompetence in adults: more than HIV negative
Authors: Zea-Vera Andres Felipe
Published: November 2019

I read a case report about Tuberculosis and fungal co-infection in a previously healthy patient published in Colomb Med (Cali) by Fontalvo et al., and I would like to address some related comments. Frequently clinicians report adult cases of patients with opportunistic infections as disseminated tuberculosis and/or fungal infections in patients consider as immunocompetent based mainly in the absence of human immunodeficiency virus infection (HIV negative). Immunocompetence is more complex than absence of HIV infection and involves a normal capacity to develop an immune response following the exposure to an antigen or broadly a normal immune response, but usually immunocompetent is define as the opposite of immunodeficiency. In the report authors said “Our aim is to report the case of an immunocompetent patient diagnosed with Mycobacterium tuberculosis and Candida albicans co-infections” but my deliberation is Do we make in the clinical practice all the efforts to consider a patient as immunocompetent? Mycobacterial, fungal and other opportunistic infections force the clinician to rule out a large list of conditions associated with secondary immunodeficiency as infectious agents (HIV, Herpesvirus, HTLV), drugs (steroids, immunosuppressants, biologics, chemotherapy) , metabolic diseases (diabetes, renal failure, cirrhosis), malignancies (leukemia, lymphomas and solid tumors) and environmental conditions (radiation, heavy metals) but even adult patients can have late onset primary genetic immunodeficiency
Association of socioeconomic stratification with plasmatic markers of lipoperoxidation and antioxidants in Venezuelan school-age children
Authors: Ruíz-Fernández Nelina , Bosch Román Virgilio , Giacopini María Isabel
Published: November 2019

Objetive:To establish association between socioeconomic status and plasmatic markers of lipoperoxidation and antioxidants in Venezuelan school-age children from the middle-class and in critical poverty.Methods:Cross-sectional study with a sample of 114 school-age children (aged 7-9). The socioeconomic status, dietary intake of macro and micro-nutrients, weight, height, lipid profile, indicators of lipid peroxidation and enzymatic and non-enzymatic antioxidants were determined.Results:The daily average intake of energy, carbohydrates and vitamin A, and the percentage of energy obtained from carbohydrates was significantly higher in middle-class children compared to critical poverty children (p <0.05). The circulating oxidized low density lipoprotein (p <0.001) and the susceptibility of low density lipoproteins and very low density lipoproteins to oxidation in vitro (p <0.05) were significantly higher in middle-class children, while the critical poverty children showed significantly lower levels of Vitamin C and E in plasma (p <0.05). Non-enzymatic antioxidant levels were frequently deficient in both strata. The concentrations of circulating oxidized low density lipoprotein (OR: 1.09, CI 95%: 1.016-1.179; p= 0.017) and Vitamin C (OR: 3.21, CI 95%: 1.104-9.938; p= 0.032) were associated to the socioeconomic status independently of gender, family history of premature coronary artery disease, triglicerides, Vitamin C and E dietary intake and count of white blood cells.Conclusion:The socioeconomic status was associated to circulating oxidized low density lipoprotein and Vitamin C in Venezuelan school-age children, The results suggested the need to improve the dietary intake of antioxidants in both studied socioeconomic groups.
Sirolimus en la enfermedad de Gorham-Stout. Caso clínico
Authors: Garcia Vanessa , Alonso-Claudio Gloria , Gómez-Hernández María Teresa , Chamorro Antonio-J
Published: November 2019

Antecedentes:La enfermedad de Gorham-Stout (EGS), es una enfermedad poco común, de etiología desconocida, caracterizada por la proliferación vascular que produce destrucción de la matriz ósea.Caso clínico:Se presenta el caso de mujer de 43 años que comienza con dolor en el esternón, disnea y tumoración abdominal junto con derrame pleural izquierdo de características serohemáticas como forma de presentación de una EGS. En pruebas de imagen que mostraron lesiones líticas en el 6º y 10º arcos costales izquierdos. Posteriormente se realizó toracotomía con biopsia pulmonar, pleural y costal observándose ausencia del extremo de la 6ª costilla. En el estudio histopatológico se describe proliferación vascular linfática en tejido óseo de pared costal. Se excluyeron otras patologías y se diagnosticó EGS.Tratamiento y resultado:Se inició tratamiento con sirolimus consiguiendo remisión completa desde el primer mes. Sin embargo, tras la suspensión del tratamiento por metrorragias, presentó reaparición de los síntomas. Se decide entonces reiniciar el tratamiento, consiguiendo nuevamente desaparición de los síntomas, tras 4 semanas de tratamiento.Relevancia clínica:Se presenta el primer caso clínico de EGS en edad adulta con derrame pleural asociado y con respuesta clínica a sirolimus, fármaco que podría ser una alternativa a la terapéutica actual.
Amyloid-beta immunotherapy: the hope for Alzheimer disease?
Authors: Barrera-Ocampo Alvaro , Lopera Francisco
Published: November 2019

Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last decade no new drugs have been found for AD despite the efforts of the scientific community and pharmaceutical companies. The Aβ immunotherapy is one of the most promising approaches to modify the course of AD. This therapeutic strategy uses synthetic peptides or monoclonal antibodies (mAb) to decrease the Aβ load in the brain and slow the progression of the disease. Therefore, this article will discuss the main aspects of AD neuropathogenesis, the classical pharmacologic treatment, as well as the active and passive immunization describing drug prototypes evaluated in different clinical trials.
Severe microscopic polyangiitis with unilateral vocal cord paralysis as initial manifestation
Authors: Flores-Suárez Luis Felipe , Alba Marco Antonio , Tona Gabriel
Published: November 2019

Case Description:A 16 year-old female who presented with initial ear, nose and throat manifestations who later progressed to severe renal disease, requiring hemodialysis after 11 months of unique laryngeal involvement.Clinical Findings:Unilateral vocal cord paralysis without other symptoms or signs, but with positive perinuclear anti-neutrophil cytoplasmic antibodies (ANCA) and anti-myeloperoxidase autoantibodies, followed an unfavorable course months later with rapidly progressive glomerulonephritis. Renal biopsy confirmed an ANCA-associated vasculitis. She was diagnosed with microscopic polyangiitis.Treatment and Outcome:High-dose glucocorticoids, intravenous cyclophosphamide, plasma exchange and finally, hemodialysis and renal transplantation.Clinical Relevance:In contrast to granulomatosis with polyangiitis (Wegener), ear, nose and throat manifestations in microscopic polyangiitis are uncommon, while involvement of the lungs and kidneys are usual. We present a case with an isolated rare involvement, which progressed to severe disease. This atypical case warns about laryngeal symptoms as initial manifestation of an anti-myeloperoxidase positive systemic vasculitides, and emphasizes the relevance of close observation when unexplained isolated conditions with accompanying evidence of autoimmunity, in this case high levels of specific autoantibodies, are present.
La trastienda de la enseñanza de lenguas extranjeras
Authors: Zou Jian
Published: December 2019

La trastienda de la enseñanza de lenguas extranjeras constituye parte de una larga lista de producción especializada del autor. Francisco García Marcos es doctor en filología por la Universidad de Granada, con una tesis sobre variación sociolingüística, y catedrático de Lingüística General en la Universidad de Almería. Sus principales preocupaciones han estado enfocadas hacia los campos de la teoría y la metodología lingüística con especial atención a la sociolingüística. Sin embargo, nunca ha dejado de transitar demasiado lejos de la enseñanza de lenguas extranjeras por las experiencias docentes tanto en la Universidad de Kiel, en la entonces República Federal de Alemania, encargándose de la enseñanza de español, como en la Universidad de Granada y, posteriormente, en la Universidad de Almería, donde fundó el Centro de Lenguas y el primer máster de español como lengua extranjera. Este trabajo parte de esa experiencia como docente en lenguas extranjeras, tal y como menciona explícitamente el autor.
Diseño, validación y aplicación de un cuestionario para medir la influencia de factores exógenos sobre la eficacia del aprendizaje invertido
Authors: Fuentes Cabrera Arturo , López Belmonte Jesús , Parra González María Elena , Morales Cevallos María Belén
Published: December 2019

Los progresos acaecidos en materia tecnológica han provocado la aparición de nuevos modelos de aprendizaje en el mundo de la educación. Entre estos modelos se encuentra el aprendizaje invertido. El objetivo de este estudio pasa por diseñar y validar un instrumento para valorar la eficacia del aprendizaje invertido, así como por conocer la incidencia de determinadas variables sociales y exógenas en su aplicación. Para ello se ha seguido un método cuantitativo a través de un diseño experimental de corte longitudinal, descriptivo y correlacional, en una muestra de 360 discentes universitarios. Para la recogida de datos se ha empleado el cuestionario generado tras el proceso de validación. Los resultados obtenidos han permitido concluir que valores adecuados en el contexto familiar, motivación, autoestima y autonomía, inciden favorablemente en la eficacia del enfoque innovador. Asimismo, la edad y el desempeño laboral de los estudiantes también resultan influyentes. Y se ha podido determinar qué factores externos ejercen mayor incidencia sobre cada aspecto constitutivo de la eficacia del aprendizaje invertido.
An intervention program to enhance social and emotional competencies in pre-service early childhood education teachers
Authors: Zych Izabela , Llorent Vicente J.
Published: December 2019

Early childhood is a crucial period for the development of social and emotional competencies. Researchers point out that teachers need to have a high level of social and emotional competencies to enhance these competencies in their students but the number of programs to promote these competencies in pre-service teachers is small. The objective of this study was to design, conduct and evaluate an intervention to promote social and emotional competencies in pre-service early childhood education teachers. The study used a non-randomized pre-test, post-test intervention-control design. The intervention included competencies such as emotional awareness and understanding, emotional management, social competence and responsible decision making. Results showed that the level of social and emotional competencies increased after the program, although statistically significant differences between the intervention and control group were found only in some dimensions. It is recommended to include similar programs in pre-service and in-service teacher education in general.
¿Son las redes sociales virtuales un espacio de ciudadanía?
Authors: Vallejos Silva Natalia , Redon Pantoja Silvia , Angulo Rasco Félix
Published: December 2019

El presente artículo, da cuenta de los resultados de un proyecto de investigación denominado: “El sentido de lo común, de las redes sociales a las redes virtuales en educación”. El objetivo de este proyecto es comprender qué tipo de ciudadanía se configura a partir de las relaciones que adolescentes entre los 12 y los 18 años mantienen en las redes sociales virtuales (Online Social Networks, OLSN).  De esta problemática, surgen dos líneas teóricas que fundamentan este propósito. En primer lugar, el concepto de ciudadanía, comprendido como un espacio social de convivencia y político de pertenencia. En segundo lugar, la gran presencia y despliegue del mundo virtual en la vida de los sujetos, como otro espacio de relaciones que podría articular formas distintas de construcción de lo político y la ciudadanía. El enfoque metodológico ha integrado distintas técnicas cualitativas: entrevistas etnográficas, grupos focales y análisis de contenido en las redes virtuales (social networks). Este artículo sólo da cuenta de los resultados centrados en las entrevistas etnográficas semiestructuradas y en los grupos focales. Los resultados analíticos de los discursos han generado dos grandes categorías que se vinculan con: 1. La ausencia de ciudadanía como territorio de lo común en las redes sociales virtuales y 2. La diferencia como exclusión y la anulación del conflicto: lo político versus la política.
EXPEDIENTE / MASTHEAD
Authors: Unicap Paralellus
Published: December 2019

Editor-GerenteProf. Dr. Newton Darwin de Andrade Cabral, PPG-CR UNICAPE-mails: newton.cabral@unicap.br / paralellus.ppgcrunicap@gmail.comADMINISTRAÇÃO SUPERIOR DA UNICAPPresidente/ChancelerPe. João Renato Eidt, S.J.Provincial dos Jesuítas do BrasilReitorProf. Dr. Pe. Pedro Rubens Ferreira Oliveira, S.J.Telefone: 2119-4110E-mail: pedro.rubens@unicap.brPró-reitoriasPró-reitora de Pesquisa e Pós-graduaçãoProfª Drª Valdenice José RaimundoTelefone: 2119-4088E-mail: valdenice.raimundo@unicap.brPró-reitor de Graduação e ExtensãoProf. Dr. Degislando Nóbrega de LimaTelefone: 2119-4055E-mail: degislando.nobrega@unicap.brPró-reitor ComunitárioProf. Dr. Pe. Lúcio Flávio Ribeiro CirneTelefone: 2119-4146E-mail: lucio.cirne@unicap.brPró-reitor AdministrativoProf. Msc. Márcio Waked de Moraes RêgoTelefone: 2119-4142E-mail: marcio.waked@unicap.brChefe de GabineteProf. Rodrigo PellegrinoTelefone: 2119-4037Email: rodrigo.pellegrino@unicap.brCoordenadora do Programa de Pós-graduação em Ciências da Religião da UNICAPProfª Drª Zuleica Dantas Pereira CamposTelefone: 2119-4022Email: zuleica.campos@unicap.brEditor coordenador do Portal de Periódicos da Universidade Católica de PernambucoMsc. Mariano Vicente da Silva FilhoTelefone: 2119-4026E-mail: mariano.vicente@unicap.br
TEOLOGIA E PÓS-MODERNIDADE: APONTAMENTOS PARA UM DISCURSO TEOLÓGICO RELEVANTE
Authors: Lima Adriano Sousa , Martins Jaziel Guerreiro
Published: December 2019

O artigo reflete sobre o tema “Teologia e pós-modernidade: apontamentos para o discurso teológico relevante”. Tendo como objetivo discutir se a teologia pode sobreviver como discurso, como logos e quais seriam as suas chances, bem como alguns dos caminhos que ela poderia trilhar, o artigo enfrenta questões fundamentais para o debate religioso, no sentido amplo, e teológico, no sentido específico. Trata-se da busca de respostas para indagações antigas, mas sempre relevantes: a religião cristã e a teologia são pertinentes na pós-modernidade? Quais seriam os novos desafios para a teologia nesse contexto? Quais seriam os rumos da teologia na época pós-moderna? Para responder tais questionamentos, os autores analisam a literatura mais relevante e atual sobre o tema, visando contribuir no âmbito acadêmico, eclesial e social. Ao final, os autores destacam que para sobreviver num tempo pós-moderno, é fundamental que a teologia se lance à tarefa de decifrar as implicações da pós-modernidade para ela e para a igreja. A teologia precisará ainda desconstruir os paradigmas modernos da interpretação do texto bíblico, a fim de responder com mais consistência os questionamentos teológicos da pós-modernidade. Assim, os autores concluem que a pós-modernidade não é um mal a ser combatido, mas um período a ser discernido e ao mesmo tempo, enriquecedor e propositivo para a experiência religiosa e para o discurso teológico relevante.Palavras-chave: Teologia; Pós-Modernidade; Religião; Experiência. THEOLOGY AND POSTMODERNITY: NOTES FOR A RELEVANT THEOLOGICAL DISCOURSEAbstractThe article adresses the topic “Theology and post-modernity: notes for a relevant theological discourse”. It discusses if Theology may thrive as a discourse, as a logos and what are its chances, such as some ways that Theology may walk. This present research deals religious debate fundamental issues in broader and strict senses. So, it is about the search for answers to ancient, but always relevant questions: are Christian religion and Theology pertinent in post-modernity? Which are the new challenges for Theology in this context? Which are the possible paths for Theology in contemporary times? In order to answer these interrogations, the text analyses the most relevant and current literature on the topic, aiming to contribute in academic, ecclesial, and social environments. Finally, so that it may survive in post-modernity, it is paramount for Theology to engage the task of deciphering the implications of postmodernity for Theology itself and for the Church. Theology will need to deconstruct modern paradigms of biblical interpretation, so that it may consistently respond to postmodern theological issues. This way, postmodernity is not and evil to fight against, but a period that has to be discerned with wisdom and responsibility. It is an enriching propositional time concerning to religious experience and relevant theological speech.Keywords: Theology; Postmodernity; Religion; Experience.
FUNDAMENTALISMO RELIGIOSO CRISTÃO E ISLÂMICO: TENDÊNCIAS SOCIOPOLÍTICAS
Authors: Costa Marcio Luis , Messias Alex Silva
Published: December 2019

Nas últimas décadas se observa o retorno da religião sob forma de fundamentalismo religioso, utilizando a mídia e instrumentos de pressão política para fazer valer suas crenças, pois diante do receio ao questionamento, os fundamentalistas veem no “outro”, no diferente, uma ameaça a ser combatida e, em alguns casos, extirpada para preservar suas convicções. O presente estudo tem por objetivo discutir as tendências sócio-políticas do fundamentalismo religioso cristão. Para tanto, com método bibliográfico narrativo, visitamos alguns autores em nível nacional e internacional, que abordam as condições que fizeram emergir o fenômeno social do fundamentalismo religioso, sua estruturação e atuação, até suas demandas sócio-políticas. Os resultados apontam que quando se identifica e transfere qualquer responsabilidade pessoal e histórica para as forças externas, o “outro”, entendido como pessoa e/ou instituição, não podemos negar que esse processo alcança dimensões de problema social. Notamos algumas tendências como mudança de movimento religioso para ideologia acirrada, da postura de fiel para militância, do “ad intra” das religiões para demandas “ad extra”, dos altares e púlpitos para ocupações políticas.Palavras-chave: Fundamentalismo Religioso; Protestante; Católico. CHRISTIAN RELIGIOUS FUNDAMENTALISM: SOCIAL-POLITICS TENDENCIESAbstractIn the last decades the return of religion in religious fundamentalism form can be observed, using media and instruments of political pressure, because when facing the fear of questioning, fundamentalists see in the “other”, in the different, a threat to be stopped and, in some cases, extirpated top preserve their convictions.  This study aims to discuss the social-politics tendencies of the Christian religious fundamentalism. For that, with the narrative bibliographic method, we visited some authors of national and international level, that approach the conditions that caused the emergence of the religious fundamentalism social phenomenon, its structure and role, until its social-politics demand. The results show that when any personal or historical responsibility is identified and transferred to external forces, the “other”, understood as person and/or institution, we cannot deny this process reaches dimensions of social problem. We notice some tendencies such as the change of the religious movement to fierce ideology, from the posture of faithful to militancy, from “ad intra” of religions to “ad extra” demands, from the altars and pulpits to political positions.Keywords: Religious Fundamentalism; Protestant; Catholic.
“UMA MINIATURA DO MUNDO DO SÉCULO 19” DE JOHN BARBER: O MOTIVO DOS DOIS CAMINHOS EM UMA GRAVURA ESTADUNIDENSE PRESBITERIANA DE 1826
Authors: Renders Helmut
Published: December 2019

Esse estudo analisa a gravura “Uma miniatura do mundo do século 19” composta e criada em 1826 por John Warner Barber (1798-1885), presbiteriano e pintor estadunidense. A narrativa visual é autônoma em comparação a outros quadros que tratam do tema dos dois caminhos, sejam eles dos países baixos ou de origem católicos ou protestante, ou do mundo anglo-saxão, ou de contemporâneos como François Georgin (1801-1863) ou Charlotte Reihlen (1805-1868).Palavras chave: Linguagens da religião; cultura visual religioso; motivo dos dois caminhos; Presbiterianos; John Warner Barber.AbstractThis study analyzes an engraving by John Warner Barber (1798-1885), a Presbyterian and American painter. It is an autonomous visual narrative in comparison to other paintings dealing with the subject of the paths, whether from the Netherlands, or from Catholic or Protestant origin, or from the Anglo-Saxon world, or works by contemporaries such as François Georgin (1801- 1863) or Charlotte Reihlen (1805-1868).Keywords: Languages of religion; religious visual culture; the motive of the two ways; Presbyterians; John Warner Barber.ResumenEste estudio analiza un grabado de John Warner Barber (1798-1885), presbiteriano y pintor estadounidense. Se trata de una narrativa visual autónoma en comparación con otros cuadros que tratan el tema de los caminos, ya sean de los Países Bajos, o de origen católico o protestante, o del mundo anglosajón, o obras de contemporáneos como François Georgin (1801- 1863) o Charlotte Reihlen (1805-1868).Palabras clave: Lenguajes de la religión; cultura visual religiosa; motivo de los dos caminos; Presbiterianos; John Warner Barber.
8-Step Enantiodivergent Synthesis of (+)- and (-)-Lingzhiol
Authors: Riehl Paul S. , Richardson Alistair D. , Sakamoto Tatsuhiro , Schindler Corinna
Published: December 2019

An 8-step enantioselective synthesis of lingzhiol is described herein. The sense of an asymmetric Michael reaction is reversed by the choice of metal source, enabling facile access to both enantiomers. A spontaneous semipinacol ring contraction enables mild construction of the lingzhiol core, and radical-mediated benzylic oxidation proceeds in the presence of an unprotected secondary alcohol. This represents the shortest enantioselective synthesis of lingzhiol to date, and the only enantiodivergent approach to both enantiomers of this meroterpenoid natural product.
Linear Viscoelasticity and Flow of Self-Assembled Vitrimers: The Case of a Polyethylene/dioxaborolane System
Authors: RICARTE RALM , Tournilhac François , Cloître Michel , Leibler Ludwik
Published: December 2019

For vitrimer systems obtained by dynamic cross-linking of polymer chains, incompatibility effects between the cross-links and polymer backbone can lead to microphase separation, resulting in a network made of cross-linked aggregates. Additionally, when there is a wide distribution of the number of cross-links per chain, macrophase separation can occur. Here, we investigate the linear viscoelasticity and flow of a polyethylene (PE) vitrimer that has cross-linkable dioxaborolane maleimide grafts, which aggregate into a hierarchical nanostructure. To elucidate the role of self-assembly, noncross-linked graft functionalized PE was first studied. It had a terminal relaxation time that was orders of magnitude larger than both neat PE and partially peroxide cross-linked PE. When dioxaborolane cross-linker was added to form the vitrimer, the resulting material could not achieve terminal relaxation within 8 hr. The graft-poor soluble and graft-rich insoluble portions of the PE vitrimer were then isolated and characterized. The soluble portion expressed similar flow behavior as neat PE, while the insoluble portion – which is a network of cross-linked aggregates – relaxed very little over 8 hr. When the insoluble and soluble portions were blended, the rheological behavior of the original vitrimer was basically recovered, showing that the soluble portion acts as a lubricant. When the insoluble portion was blended with neat PE, the material relaxed much more stress, but still did not reach steady-state flow within 8 hr. When high stresses were applied, however, PE vitrimer flowed. Nonlinear rheology experiments revealed melt fracture at high strains and suggested that flow is enabled by rapid healing, which follows fracture events. The presence of macroscopic phase separation facilitated flow.
Radical C‒N Borylation of Aromatic Amines Enabled by a Pyrylium Reagent
Authors: Ma Yuanhong , Pang Yue , niski jan , Leutzsch Markus , Cornella Josep
Published: December 2019

Herein, we report a radical borylation of aromatic amines through a homolytic C(sp2)‒N bond cleavage. This method capitalizes on a simple and mild activation via a pyrylium reagent (ScPyry-OTf) thus priming the amino group for reactivity. The combination of terpyridine and a diboron reagent triggers a radical reaction which cleaves the C(sp2)‒N bond and forges a new C(sp2)‒B bond. The unique non-planar structure of the pyridinium intermediate, provides the necessary driving force for the aryl radical formation. The method permits borylation of a wide variety of aromatic amines indistinctively of the electronic environment.
Thermal Spin Crossover in Fe(II) and Fe(III). Accurate Spin State Energetics at the Solid State
Authors: Vela Sergi , Fumanal Maria , Cirera Jordi , Ribas Jordi
Published: December 2019

The thermal Spin Crossover (SCO) phenomenon refers to an entropy-driven spin transition in some materials based on d6-d9 transition metal complexes. While its molecular origin is well known, intricate SCO behaviours are increasingly common, in which the spin transition occurs concomitantly to e.g. phase transformations, solvent absorption/desorption, or order-disorder processes. The computational modelling of such cases is challenging, as it requires accurate spin state energies in the solid state. Density Functional Theory (DFT) is the best framework, but most DFT functionals are unable to balance the spin state energies. While few hybrid functionals perform better, they are still too expensive solid-state minima searches in moderate-size systems. The best alternative is to dress cheap local (LDA) or semi-local (GGA) DFT functionals with a Hubbard-type correction (DFT+U). However, the parametrization of U is not straightforward due to the lack of reference values, and because ab initio parametrization methods perform poorly. Moreover, SCO complexes undergo notable structural changes upon transition, so intra- and inter-molecular interactions might play an important role in stabilizing either spin state. As a consequence, the U parameter depends strongly on the dispersion correction scheme that is used. In this paper, we parametrize U for nine reported SCO compounds (five based on FeII, 1-5 and four based on FeIII, 6-9) when using the D3 and D3-BJ dispersion corrections. We analyze the impact of the dispersion correction treatments on the SCO energetics, structure, and the unit cell dimensions. The average U values are different for each type of metal ion (FeII vs. FeIII), and dispersion correction scheme (D3 vs. D3-BJ) but they all show excellent transferability, with mean absolute errors (MAE) below chemical accuracy (i.e. MAE < 4 kJ/mol). This enables a better description of SCO processes and, more generally, of spin state energetics, in materials containing FeII and FeIII ions.
Superionic Lithium Intercalation through 2 nm x 2 nm Columns in the Crystallographic Shear Phase Nb18W8O69
Authors: Griffith Kent , Grey Clare P.
Published: December 2019

Nb18W8O69 (9Nb2O5×8WO3) is the tungsten-rich end-member of the Wadsley–Roth crystallographic shear (cs) structures within the Nb2O5–WO3 series. It has the largest block size of any known, stable Wadsley–Roth phase, comprising 5 ´ 5 units of corner-shared MO6 octahedra between the shear planes, giving rise to 2 nm ´ 2 nm blocks. Rapid lithium intercalation is observed in this new candidate battery material and 7Li pulsed field gradient nuclear magnetic resonance spectroscopy – measured in a battery electrode for the first time at room temperature – reveals superionic lithium conductivity. In addition to its promising rate capability, Nb18W8O69 adds a piece to the larger picture of our understanding of high-performance Wadsley–Roth complex metal oxides.
Hierarchical Porous Carbon Arising from MOF Encapsulated Bacteria and its Energy Storage Potential
Authors: Li Shaobo , Zhou Xiaoshuang , Chen Zhuo , Herbert Fabian C. , Jayawickramage Rangana , Panangala Samitha D. , Luzuriaga Michael A. , Alahakoon Sampath B. , Mohottalalage Shashini , Meng Xin , Fei Ling , Ferraris John P. , Smaldone Ron , Gassensmith Jeremiah J.
Published: December 2019

Hierarchical porous carbons (HPCs) hold great promise in energy-related applications owing to their excellent chemical stability and well-developed porous structures. Attention has been drawn toward developing new synthetic strategies and precursor materials that permit greater control over composition, size, morphology, and pore structure. There is a growing trend of employing metal-organic frameworks (MOFs) as HPC precursors as their highly customizable characteristics favor new HPC syntheses. In this article, we report a biomimetically grown bacteria-templated MOF synthesis where the bacteria not only facilitate the formation of MOF nanocrystals, but also provides morphology and porosity control. The resultant HPCs show improved electrochemical capacity behavior compared to pristine MOF derived HPCs. Considering the broad availability of bacteria and ease of its production, in addition to significantly improved MOF growth efficiency on bacterial templates, we believe that bacteria-templated MOF is a promising strategy to produce a new generation of HPCs.
Role of Alexithymia in Predicting Self-Efficacy in Academic Students of a North Indian Institution: A Cross Sectional Study
Authors: Devanshu Chaudhary  , Anjali Meena
Published: November 2019

INTRODUCTION: Alexithymia is a cognitive-affective style and a personality construct that is associated with various physical and psychological disorders. It refers to a personality trait associated with difficulties with identifying or describing feelings, mental imaging and fantasy, and external cognitive orientation

AIM: To access the problem of alexithymia among the Academic (Dental and Ayurvedic) students of an Institution in North India.

MATERIALS AND METHOD: A questionnaire based cross-sectional survey was carried out among the medical students of D.J. Group of Institutions, Modinagar, Ghaziabad district, Uttar Pradesh, India. Ethical approval was obtained from the Institutional Review Board, Modinagar and informed consent was obtained from all the study participants prior to the study.

RESULTS: The questionnaire based study was carried out among 252 medical students of D.J. Group of Institutions, Modinagar, Ghaziabad district, Uttar Pradesh, India. Out of which 113 students were of Ayurveda and 139 were dental students. The inter group comparison of respondents according to course of study in which majority of the Ayurveda students were having significant result for the alexithymia problem.

CONCLUSION: This study demonstrates that alexithymia plays significant role in decreasing self-efficacy in academic students. As alexithymia is high in college students and affects self-regulation, goal orientation, and academic function, we suggest that mental physicians routinely evaluate medical college students for alexithymia.
Flexible Denture: A Hope for Partial Edentulous Patient- A Case Report
Authors: Gitanjali Mago  , Puneet Sharma
Published: November 2019

The various treatment options for the aesthetic and functional rehabilitation of partially edentulous patients are conventional fixed partial dentures, implant supported fixed partial dentures and removable partial dentures. In some cases, removable partial dentures may be the only choice which is available other than implants and fixed partial denture. Removable cast partial dentures are used as definitive removable prostheses when indicated, but location of clasps is not aesthetically pleasant. So, when patient is concerned about aesthetics, flexible partial dentures which is aesthetically superior may be considered. But for the success of flexible removable partial denture, proper diagnosis, treatment planning, insertion, wearing and maintenance of this prosthesis is very important.
A Systematic Review on Sleep Related Disorders and Periodontal Disease
Authors: Rahul Kumar  , Rupali Kalsi  , Stuti Gupta  , Neetika Gupta
Published: November 2019

BACKGROUND: Periodontitis has been implicated in many systemic diseases such as diabetes, cardiovascular diseases, hypertension, stroke, Obesity, Kidney disorders. Recent scientific evidence has revealed a relationship between sleep related breathing disorders (SRBDs) and periodontal diseases. There has been a recent scientific evidence on population based studies reflecting an association between periodontal diseases and OSA. 

AIM: The tenet of the study was to find out interconnect between obstructive sleep apnea and periodontal disease.

METHODS: A systematic review of clinical trials assessing the relationship between OSA and periodontitis was carried out. An electronic search based on internet search sites (From 2000-2016) by PubMed, MEDLINE, SCOPUS, EMBASE, Google scholar, CINAHL, and Web of Science (WoS) were used. Studies which met the inclusion criteria were further analysed to find out the outcome of the study.

RESULTS:  A total of 174 potentially qualifying studies were screened. Out of them 10 studies  fulfilled the inclusion criteria which were further analysed. In our study 10 studies (2000-2016) from Jordan, Tokyo, Turkey, Saudi Arabia, India, USA, South Korea, Taiwan, Australia were shortlisted. Out of them 5 were cross sectional studies, 4 were case control, and 1 was meta-analysis. The sample size in the studies ranged from 66 to 30,120 adult falling in age range of 18 to 75.  The indicators for OSA used were as positive Epsworth sleepiness scale (ESS), Berlin Questionnaire, STOP-bang questionnaire, Apnea-Hypopnea index, Polysomnography (PSG). And the indicators for periodontal disease were Plaque index (PI), Clinical attachment level (CAL), Pocket Probing Depth (PPD), Gingival Bleeding Index (GBI). Majority of studies showed positive correlation between OSA and periodontal disease.

CONCLUSION: Recent evidence and literature suggests that there exist a strong  interconnect between OSA and periodontal disease. Dentist play a pivotal role in diagnosis and timely management of OSA cases so as to halt progression of sleep apnea and periodontitis.
interpersonal meaning in students' explanation texts
Authors: Hadiani Dini
Published: December 2019

This study is aimed to investigate the interpersonal meaning in students’ explanation texts. Six texts taken from students’ writings were used as the instruments of text analysis. The theories of Systemic Functional Linguistics and explanation text were used as the framework of the text analysis. The findings show that students have employed mood types which are formed by the Subject and Finite as Mood element and predicator and complement as Residue. The arrangement of Subject and Finite in the clauses demonstrates that declarative mood is used dominantly in the texts to realize the speech function of a statement. It suggests that the students have attempted to provide the information to the readers which are relevant to the social function of the explanation text. Moreover, the little use of modality in students’ texts indicates that the students present factual information. This evidence has shown the students’ efforts to position themselves in the texts and to build relationships with the readers. In conclusion, students have been able to create an effective explanation text which is intended to inform how something is done.
ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival
Authors: Van Duzer Avery , Taniguchi Sachiko , Elhance Ajit , Tsujikawa Takahiro , Oshimori Naoki
Published: December 2019

Invasive squamous cell carcinoma (SCC) is aggressive cancer with a high risk of recurrence and metastasis, but the critical determinants of its progression remain elusive. Here, we identify ADAP1, a GTPase-activating protein (GAP) for ARF6 up-regulated in TGF-β-responding invasive tumor cells, as a strong predictor of poor survival in early-stage SCC patients. Using a mouse model of SCC, we show that ADAP1 overexpression promotes invasive tumor progression by facilitating cell migration and breakdown of the basement membrane. We found that ADAP1-rich, TGF-β-responding tumor cells exhibit cytoplasmic laminin localization, which correlated with the absence of laminin and type IV collagen from the pericellular basement membrane. Interestingly, although tumors overexpressing a GAP activity-deficient mutant of ADAP1 resulted in morphologically complex tumors, those tumor cells failed to breach the basement membrane. Moreover,Adap1deletion in tumor cells ameliorated the basement membrane breakdown and had less invading cells in the stroma. Our study demonstrates that ADAP1 is a critical mediator of TGF-β-induced cancer invasion and might be exploited for the treatment of high-risk SCC.
Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compounds
Authors: Ray Sandipan , Lach Radoslaw , Heesom Kate J , Valekunja Utham K , Encheva Vesela , Snijders Ambrosius P , Reddy Akhilesh B
Published: December 2019

Determining the exact targets and mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock-related disorders. Here, we have used phenotypic proteomic profiling (PPP) to systematically determine molecular targets of four circadian period–lengthening compounds in human cells. We demonstrate that the compounds cause similar changes in phosphorylation and activity of several proteins and kinases involved in vital pathways, including MAPK, NGF, B-cell receptor, AMP-activated protein kinases (AMPKs), and mTOR signaling. Kinome profiling further indicated inhibition of CKId, ERK1/2, CDK2/7, TNIK, and MST4 kinases as a common mechanism of action for these clock-modulating compounds. Pharmacological or genetic inhibition of several convergent kinases lengthened circadian period, establishing them as novel circadian targets. Finally, thermal stability profiling revealed binding of the compounds to clock regulatory kinases, signaling molecules, and ubiquitination proteins. Thus, phenotypic proteomic profiling defines novel clock effectors that could directly inform precise therapeutic targeting of the circadian system in humans.
Editorial
Authors: Parayre Catherine
Published: December 2019

Editorial, Voix plurielles 16.2 (2019)
Lacelle, Andrée, dir. Poèmes de la résistance
Authors: Hauck Nicholas
Published: December 2019

Compte rendu

Lacelle, Andrée, dir. Poèmes de la résistance
Fahmy, Jean Mohsen. La sultane dévoilée
Authors: Antoine Fabien
Published: December 2019

Compte rebdu

Fahmy, Jean Mohsen. La sultane dévoilée
TINJAUAN DEBIT PADA SUMUR AIR TANAH BERBASIS POMPA AIR TENAGA SURYA
Authors: Iqbal Muh. taufik , Kushari Kushari
Published: December 2019

To optimize the planting of rice plants, groundwater is used as a source of water so that the water needs for agricultural land can be met. Groundwater, which is a source of water, is known to contribute greatly to agricultural production, especially in the dry season. The long-term goal of this research is to increase groundwater discharge using a water pump as a controller of water distribution, alternative energy in the form of solar energy is used to drive the pump engine. During this time the pump is driven by an oil-fueled engine (BBM) which produces CO2 emissions into the air. The use of non-fuel alternative energy is expected to help reduce CO2 emissions so far. The research method begins with a survey and field survey conducted by the groundwater irrigation network in the Pare-Pare district. then search along ground waterways and mark using GPS. Measuring discharge and analyzing the performance of solar water pumps. To optimize the planting of rice plants, groundwater is used as a source of water so that the water needs for agricultural land can be met. Groundwater, which is a source of water, is known to contribute greatly to agricultural production, especially in the dry season. The long-term goal of this research is to increase groundwater discharge using a water pump as a controller of water distribution, alternative energy in the form of solar energy is used to drive the pump engine. During this time the pump is driven by an oil-fueled engine (BBM) which produces CO2 emissions into the air. The use of non-fuel alternative energy is expected to help reduce CO2 emissions so far. The research method begins with a survey and field survey conducted by the groundwater irrigation network in the Pare-Pare district. then search along ground waterways and mark using GPS. Measuring discharge and analyzing the performance of solar water pumps.
PERBEDAAN PENGARUH PEMBERIAN ANGKAK DALAM PEMBUATAN SOSIS AYAM TERHADAP SIFAT FISIK DAN ORLAB
Authors: Sudjatinah Sudjatinah , Wibowo C. Hari
Published: November 2019

Sosis daging ayam adalah bahan pangan yang berasal dari potongan kecil daging ayam yang digiling dan diberi bumbu. Bahan sosis yang digunakan adalah daging ayam, karena daging merupakan white meat jadi terlihat pucat jika diolah menjadi sosis berbeda dengan sosis daging sapi, oleh karena itu dilakukan penambahan pewarna alami yang aman dikonsumsi yaitu angkak. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan pengaruh konsentrasi angkak sebagai pewarna alami terhadap sifat fisik dan orlab sosis daging ayam.

Metode yang digunakan dalam penelitian ini adalah metode experimental laboratories. Faktor perlakuan yang diterapkan adalah tanpa penambahan angkak (0 %) dan penambahan angkak 1,5 %.  Variabel yang diamati yaitu sifat fisik (kadar air, cooking loss), kekenyalan dan orlab. Data yang diperoleh dianalisis menggunakan t test.   Hasil penelitian yang telah dilakukan menunjukkan bahwa perlakuan penambahan angkak dengan konsentrasi yang berbeda dalam pembuatan sosis daging ayam afkir (sebagai pewarna alami) berpengaruh nyata (p<0,05) terhadap rata-rata cooking loss tetapi tidak berbeda pada rata-rata kadar air dan kekenyalan. Penambahan angkak dengan konsentrasi 1,5% pada pengolahan sosis daging ayam (sebagai pewarna alami) menghasilkan karakteristik mutu sosis daging ayam yang lebih baik dengan syarat mutu sosis daging ayam dibandingkan tanpa penambahan angkak. 