bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrothermal Treatment of Arsenic Sulfide Residues from Arsenic-Bearing Acid Wastewater
Authors: Yao Liwei , Min Xiaobo , Xu Hui , Ke Yong , Liang Yanjie , Yang Kang
Published: August 2018

Arsenic sulfide residue (ASR), a by-product from the treatment of arsenic-bearing acidic wastewater, is abundantly generated but not properly disposed of in China. The utilization of such high-content arsenic waste residue is limited by the market. The traditional methods of stabilization/solidification (S/S) by lime cement or iron salt have a large mass/volume addition, high dumping cost and secondary pollution risk. In this paper, hydrothermal technology was used to treat three kinds of ASRs obtained from different smelters to minimize waste. The leaching toxicity and chemical speciation of the generated products was also evaluated by TCLP and BCR analyses. It was found that the hydrothermal treatment could greatly reduce the volume and moisture content of the ASRs. TCLP tests showed that the leachability of arsenic and heavy metals significantly decreased after the treatment. According to the BCR analysis, most of the unstable As, Cd and Cr transformed into a residual fraction. Finally, XRD, SEM, Raman and XPS techniques were carried out to reveal the mechanism. As a result, hydrothermal treatment can efficiently achieve the dehydration, volume reduction and stabilization/solidification of ASRs.
Tenogenic Properties of Mesenchymal Progenitor Cells Are Compromised in an Inflammatory Environment
Authors: Brandt Luisa , Schubert Susanna , Scheibe Patrick , Brehm Walter , Franzen Jan , Gross Claudia , Burk Janina
Published: August 2018

Transplantation of multipotent mesenchymal progenitor cells is a valuable option for treating tendon disease. Tenogenic differentiation leading to cell replacement and subsequent matrix modulation may contribute to the regenerative effects of these cells, but it is unclear whether this occurs in the inflammatory environment of acute tendon disease. Equine adipose-derived stromal cells (ASC) were cultured as monolayers or on decellularized tendon scaffolds in static or dynamic conditions, the latter represented by cyclic stretching. The impact of different inflammatory conditions, as represented by supplementation with interleukin-1β and/or tumor necrosis factor-α or by co-culture with allogeneic peripheral blood leukocytes, on ASC functional properties was investigated. High cytokine concentrations increased ASC proliferation and osteogenic differentiation, but decreased chondrogenic differentiation and ASC viability in scaffold culture, as well as tendon scaffold repopulation, and strongly influenced musculoskeletal gene expression. Effects regarding the latter differed between the monolayer and scaffold cultures. Leukocytes rather decreased ASC proliferation, but had similar effects on viability and musculoskeletal gene expression. This included decreased expression of the tenogenic transcription factor scleraxis by an inflammatory environment throughout culture conditions. The data demonstrate that ASC tenogenic properties are compromised in an inflammatory environment, with relevance to their possible mechanisms of action in acute tendon disease.
Protective Effects of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside on Ovariectomy Induced Osteoporosis Mouse Model
Authors: Kim Su-Jin , Hwang Yun-Ho , Mun Seul-Ki , Hong Seong-Gyeol , Kim Kwang-Jin , Kang Kyung-Yun , Son Young-Jin , Yee Sung-Tae
Published: August 2018

2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside (TSG), an active polyphenolic component of Polygonum multiflorum, exhibits many pharmacological activities including antioxidant, anti-inflammation, and anti-aging effects. A previous study demonstrated that TSG protected MC3T3-E1 cells from hydrogen peroxide (H2O2) induced cell damage and the inhibition of osteoblastic differentiation. However, no studies have investigated the prevention of ovariectomy-induced bone loss in mice. Therefore, we investigated the effects of TSG on bone loss in ovariectomized mice (OVX). Treatment with TSG (1 and 3 μg/g; i.p.) for six weeks positively affected body weight, uterine weight, organ weight, bone length, and weight change because of estrogen deficiency. The levels of the serum biochemical markers of calcium (Ca), inorganic phosphorus (IP), alkaline phosphatase (ALP), and total cholesterol (TCHO) decreased in the TSG-treated mice when compared with the OVX mice. Additionally, the serum bone alkaline phosphatase (BALP) levels in the TSG-treated OVX mice were significantly increased compared with the OVX mice, while the tartrate-resistant acid phosphatase (TRAP) activity was significantly reduced. Furthermore, the OVX mice treated with TSG showed a significantly reduced bone loss compared to the untreated OVX mice upon micro-computed tomography (CT) analysis. Consequently, bone destruction in osteoporotic mice as a result of ovariectomy was inhibited by the administration of TSG. These findings indicate that TSG effectively prevents bone loss in OVX mice; therefore, it can be considered as a potential therapeutic for the treatment of postmenopausal osteoporosis.
Comparative Proteome Analysis Reveals Lipid Metabolism-Related Protein Networks in Response to Rump Fat Mobilization
Authors: Wang Juanjuan , Xu Mengsi , Wang Xinhua , Yang Jinquan , Gao Lei , Zhang Yan , Huang Xin , Han Mengli , Gao Rui , Gan Shangquan
Published: August 2018

Altay is a typical fat-tailed sheep breed displaying the unique ability to rapidly mobilize fat, which is vital for maintaining a normal metabolism that facilitates its survival in lengthy winter conditions. However, the physiological, biochemical, and molecular mechanisms underlying fat mobilization remain to be elucidated. In this study, the monitoring of rump fat adipocyte sizes disclosed a positive correlation between cell size and fat deposition ability. In addition, we subjected sheep to persistent starvation to imitate the conditions that trigger rump fat mobilization and screened 112 differentially expressed proteins using the isobaric peptide labeling approach. Notably, increased secretion of leptin and adiponectin activated the key fat mobilization signaling pathways under persistent starvation conditions. Furthermore, the upregulation of resistin (RETN), heat-shock protein 72 (HSP72), and complement factor D (CFD) promoted lipolysis, whereas the downregulation of cell death-inducing DFFA-like effector C (CIDEC) inhibited lipid droplet fusion, and the increase in HSP72 and apolipoprotein AI (Apo-AI) levels activated the body’s stress mechanisms. The synergistic actions of the above hormones, genes, and signaling pathways form a molecular network that functions in improving the adaptability of Altay sheep to extreme environments. Our findings provide a reference for elucidating the complex molecular mechanisms underlying rump fat mobilization.
A Review of HPV-Related Head and Neck Cancer
Authors: Kobayashi Kazuhiro , Hisamatsu Kenji , Suzui Natsuko , Hara Akira , Tomita Hiroyuki , Miyazaki Tatsuhiko
Published: August 2018

Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal lining of the upper aerodigestive tract. Tobacco and alcohol use have been reported to be associated with HNSCC. Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. It is now widely accepted that high-risk HPV is a cause of almost all cervical cancers as well as some forms of HNSCCs. HPV-related HNSCCs are increasing. HPV-related HNSCCs and HPV-unrelated HNSCCs differ with respect to the molecular mechanisms underlying their oncogenic processes. HPV-related HNSCCs are known to have a better prognosis response to treatment as compared with HPV-unrelated HNSCCs. Therefore, in recent years, it has been required to accurately discriminate between HPV-related and HPV-unrelated HNSCCs. To diagnose the HPV-related HNSCCs, various methods including P16 immunohistochemistry, FISH, and genetic analyses of the HPV gene from histopathological and liquid biopsy specimens have been employed. Based on the results of the differential diagnosis, various treatments employing EGFR TKI and low-dose radiation have been employed. Here, we review the involvement of the HPV virus in HNSCCs as well as the molecular mechanism of carcinogenesis, classification, prognosis, diagnostic procedures, and therapy of the disease.
Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease
Authors: Dey Tapan , Kalita Jatin , Weldon Sinéad , Taggart Clifford C.
Published: August 2018

In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease.
Improved Tribocorrosion Resistance of a CoCrMo Implant Material by Carburising
Authors: Cassar Josianne , Mallia Bertram , Mazzonello Antonino , Karl Andreas , Buhagiar Joseph
Published: August 2018

Tribocorrosion damage is a cause for the premature failure of hip implants made of cobalt-based alloys. Low-temperature carburising can be a plausible solution towards mitigating the tribocorrosion damage of articulating components. This diffusion treatment introduces a supersaturated carbon solid solution, termed S-phase, which hardens the CoCrMo alloy without detriment to the corrosion resistance. This work investigates and compares the tribocorrosion behaviour of untreated and carburised ASTM F1537 CoCrMo alloys tested in Ringer’s solution using a reciprocating sliding configuration against a polycrystalline alumina counterface under different electrochemical conditions. The research shows that whereas the carburised alloy suffered a slightly higher wear loss under a cathodic potential, it was able to reduce the material losses considerably when tested under both open circuit and anodic potential conditions. Under anodic conditions material losses by corrosion due to wear dominated. The better tribocorrosion resistance of the carburised layer was attributed to the better qualities of the passive film for the carburised sample coupled with an increased load support.
Polystyrene Opals Responsive to Methanol Vapors
Authors: Burratti Luca , Casalboni Mauro , De Matteis Fabio , Pizzoferrato Roberto , Prosposito Paolo
Published: August 2018

Photonic crystals (PCs) show reflectance spectra depending on the geometrical structure of the crystal, the refractive index (neff), and the light incident angle, according to the Bragg-Snell law. Three-dimensional photonic crystals (3D-PCs) composed of polymeric sub-micrometer spheres, are arranged in an ordered face cubic centered (fcc) lattice and are good candidates for vapor sensing by exploiting changes of the reflectance spectra. We synthesized high quality polystyrene (PS) 3D-PCs, commonly called opals, with a filling factor f near to the ideal value of 0.74 and tested their optical response in the presence of different concentrations of methanol (MeOH) vapor. When methanol was present in the voids of the photonic crystals, the reflectance spectra experienced energy shifts. The concentration of methyl alcohol vapor can be inferred, due to a linear dependence of the reflectance band maximum wavelength as a function of the vapor concentration. We tested the reversibility of the process and the time stability of the system. A limit of detection (LOD) equal to 5% (v/v0), where v was the volume of methanol and v0 was the total volume of the solution (methanol and water), was estimated. A model related to capillary condensation for intermediate and high methanol concentrations was discussed. Moreover, a swelling process of the PS spheres was invoked to fully understand the unexpected energy shift found for very high methanol content.
Clinical and Environmental Predictors of Health-Related Quality of Life in Lithuanian Children and Adolescents with Spina Bifida: A Cross-Sectional Analysis of a Nationally Represented Sample
Authors: Bakanienė Indrė , Prasauskienė Audronė
Published: August 2018

Background and objectives: In pediatric chronic health conditions, health-related quality of life (HRQOL) is a useful indicator of health, development, and well-being. The purpose of the study was to assess the effect of clinical and environmental factors on the HRQOL of children and adolescents with spina bifida (SB). Materials and methods: A cross-sectional study of the sample of 99 children and adolescents with SB aged 5 to 17 years. The questionnaires used in the study were the Spina Bifida Health-Related Quality of Life instrument (HRQOL-SB), and the Participation and Environment Measure for Children and Youth. Medical data were obtained from the medical records and the clinical examination. Results: A multivariate linear regression revealed that the most potent predictors of the HRQOL in children with SB were the community overall environmental supports (β = 0.504; p = 0.0001), a number of health conditions (β = −0.395; p = 0.0001), access to personal transportation (β = 0.236; p = 0.023), and supplies (β = 0.181; p = 0.031), explaining 80.3% of the variance in the SB-HRQOL scores. The most significant predictors of the HRQOL in adolescents were a number of health conditions (β = −0.387; p = 0.0001), cognitive demands of activities at home (β = 0.345; p = 0.0001), supplies (β = 0.267; p = 0.0001), money (β = 0.303; p = 0.0001), physical layout at school (β = 0.188; p = 0.008), and access to public transportation (β = 0.206; p = 0.019), explaining 89.5% of the variance in the SB-HRQOL scores. Conclusions: Both clinical and environmental factors determined the HRQOL of children and adolescents with SB. Environmental supports and resources contributed to HRQOL more than medical problems, especially in adolescents. The number of associated medical problems, reflecting disease severity, was the more potent clinical predictor compared to an individual health problem.
Current Research on the Safety of Pyrethroids Used as Insecticides
Authors: Chrustek Agnieszka , Hołyńska-Iwan Iga , Dziembowska Inga , Bogusiewicz Joanna , Wróblewski Marcin , Cwynar Anna , Olszewska-Słonina Dorota
Published: August 2018

Pyrethroids are synthetic derivatives of natural pyrethrins extracted from Chrysanthemum cinerariaefolium. They are 2250 times more toxic to insects than to vertebrates due to insects’ smaller size, lower body temperature and more sensitive sodium channels. In particular, three pyrethroid compounds, namely deltamethrin, permethrin, and alpha-cypermethrin, are commonly used as insecticides and are recommended for in-home insect control because they are considered to be relatively non-toxic to humans in all stages of life. However, recent data show that they are not completely harmless to human health as they may enter the body through skin contact, by inhalation and food or water, and absorption level depending on the type of food. Permethrin seems to have an adverse effect on fertility, the immune system, cardiovascular and hepatic metabolism as well as enzymatic activity. Deltamethrin induces inflammation, nephro- and hepatotoxicity and influences the activity of antioxidant enzymes in tissues. Alpha-cypermethrin may impair immunity and act to increase glucose and lipid levels in blood. The aim of the review is to provide comprehensive information on potential hazards associated to human exposure to deltamethrin, permethrin and alpha-cypermethrin. The results of presented studies prove that the insecticides must be used with great caution.
Quantitative and Qualitative Analysis of Hydrogen Accumulation in Hydrogen-Storage Materials Using Hydrogen Extraction in an Inert Atmosphere
Authors: Babikhina Maria N. , Kudiiarov Viktor N. , Mostovshchikov Andrei V. , Lider Andrey M.
Published: August 2018

Currently, standard samples with high hydrogen concentrations that meet the requirements of hydrogen extraction in an inert atmosphere are not currently available on the market. This article describes the preparation of Ti-H standard samples and the calibration of RHEN602, a hydrogen analyzer, using LECO (LECO, Saint Joseph, MI, USA). Samples of technically pure titanium alloy were chosen as the material for sample production. The creation procedure includes five main steps: sample preparation (polishing to an average roughness of 0.04 μm using sandpaper), annealing, hydrogenation, maintenance in an inert gas atmosphere, and characterization of the samples. The absolute hydrogen concentration in the samples was determined by two methods: volumetric and mass change after the introduction of hydrogen. Furthermore, in-situ X-ray diffraction, temperature programmed desorption (TPD) analysis, and thermogravimetric analysis were used during measurements to investigate the phase transitions in the samples. As a result of this work, a series of calibration samples were prepared in a concentration range up to 4 wt % hydrogen, optimal parameters for measuring high concentrations of hydrogen. The calibration line was obtained and the calibration error was 10%.
A Kinetic Study on the Preparation of AlNi Alloys by Aluminothermic Reduction of NiO Powders
Authors: Beltran Cesar , Valdes Alfredo , Torres Jesús , Palacios Rocio
Published: August 2018

In this work, the experimental results obtained during the preparation of Al-Ni and Al-Ni-Mg alloys using the aluminothermic reduction of NiO by submerged powder injection, assisted with mechanical agitation are presented and discussed. The analyzed variables were melt temperature, agitation speed, and initial magnesium concentration in the molten alloy. For some of the experiments performed, it was found that the Ni concentration increased from 0 to about 3 wt-% after 90 min of treatment at constant temperature and constant agitation speed. In order to determine the values of the kinetic parameters of interest, such as the activation energy and the rate constants, the values of the results obtained were fitted to the kinetic formulae available. Moreover, the kinetics of the reaction were found to be governed by the diffusion of Al and Mg to the NiO boundary layer, where MgAl2O4 or Al2O3 were formed as the main reaction products. Finally, from a thermodynamic study of the system, the main reactions that took place are explained.
Investigation on Microstructure of Beetle Elytra and Energy Absorption Properties of Bio-Inspired Honeycomb Thin-Walled Structure under Axial Dynamic Crushing
Authors: Du Jianxun , Hao Peng
Published: August 2018

The beetle elytra requires not only to be lightweight to make a beetle fly easily, but also to protect its body and hind-wing from outside damage. The honeycomb sandwich structure in the beetle elytra make it meet the above requirements. In the present work, the microstructures of beetle elytra, including biology layers and thin-walled honeycombs, are observed by scanning electron microscope and discussed. A new bionic honeycomb structure (BHS) with a different hierarchy order of filling cellular structure is established. inspired by elytra internal structure. Then the energy absorbed ability of different bionic models with the different filling cell size are compared by using nonlinear finite element software LS-DYNA (Livermore Software Technology Corp., Livermore, CA, USA). Numerical results show that the absorbed energy of bionic honeycomb structures is increased obviously with the increase of the filling cell size. The findings indicate that the bionic honeycomb structure with second order has an obviously improvement over conventional structures filled with honeycombs and shows great potential for novel clean energy absorption equipment.
Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women
Authors: Rivera-Paredez Berenice , Macías Nayeli , Martínez-Aguilar Mayeli M. , Hidalgo-Bravo Alberto , Flores Mario , Quezada-Sánchez Amado D. , Denova-Gutiérrez Edgar , Cid Miguel , Martínez-Hernández Angelica , Orozco Lorena , Quiterio Manuel , Flores Yvonne N. , Salmerón Jorge , Velázquez-Cruz Rafael
Published: August 2018

Genome-wide association studies in people with European ancestry suggest that polymorphisms in genes involved in vitamin D (VD) metabolism have an effect on serum concentrations of 25-hydroxyvitamin D. However, nothing is known about these polymorphisms in populations with Amerindian ancestry. Our aim was to evaluate the association between genetic variants on the vitamin D receptor (VDR) and the vitamin D binding protein (GC) genes, involved in the VD pathway, and VD deficiency in 689 unrelated Mexican postmenopausal women. We also described the frequencies of these variants in 355 postmenopausal women from different ethnic groups. Based on our preliminary results of 400 unrelated Mexican postmenopausal women, three single nucleotide polymorphisms (SNPs) were selected for genotyping. The SNPs rs4516035 in VDR and rs2282679 in GC were associated with VD deficiency. Additionally, women who carried three risk alleles had a 3.67 times higher risk of suffering VD deficiency, compared to women with no risk alleles (p = 0.002). The rs4516035-C allele frequency in the Amerindian population was enriched in the South East region of Mexico. In contrast, the highest frequency of the rs2298850-C allele, a proxy for the tag SNP rs2282679, was observed in the South region. Our results indicate that genetic variants in VDR and GC genes are associated with VD deficiency in Mexican postmenopausal women. Moreover, an association was observed for the variants rs3794060 and rs4944957 of the DHCR7/NADSYN1 gene with osteopenia/osteoporosis.
Comparative Effects of Native and Defatted Flaxseeds on Intestinal Enzyme Activity and Lipid Metabolism in Rats Fed a High-Fat Diet Containing Cholic Acid
Authors: Opyd Paulina M. , Jurgoński Adam , Juśkiewicz Jerzy , Fotschki Bartosz , Koza Jarosław
Published: August 2018

We hypothesize that defatting is an important factor that can determine the beneficial effects of flaxseeds on rats with diet-induced disorders. The experiment lasts 8 weeks and is conducted on Wistar rats allocated to four groups as follows: a control group fed with a standard diet; a high-fat (HF) group fed with a diet containing 21% fat and 0.1% cholic acid as a stimulator of lipid absorption; an HF group fed a diet supplemented with 1% native flaxseeds; and an HF group fed a diet supplemented with 1% defatted flaxseeds. In the HF group, several unfavourable changes in the gut and lipid metabolism are observed. Supplementation of the HF diet with native flaxseeds prevent an increase in colonic β-glucuronidase activity, whereas dietary defatted flaxseeds increase mucosal disaccharidase activities in the small intestine (sucrose, maltase and lactase). Regardless of the form of supplementation, dietary flaxseeds increase bacterial glycolytic activity in the distal intestine and decrease hepatic fat, especially triglyceride, accumulation. Both flaxseed forms decrease lipid peroxidation in the kidneys and increase the blood HDL cholesterol concentration with the native form being more efficient in the former and the defatted form being more efficient in the latter. The lipid-modulating effects of defatted flaxseeds are associated with reduced hepatic expression of peroxisome proliferator-activated receptor α, which is not the case in terms of native flaxseeds. Dietary supplementation with a relatively small amount of flaxseeds can exert beneficial effects on gut functions and lipid metabolism in rats, and these effects are affected by defatting to some extent.
Intravenous Irons: From Basic Science to Clinical Practice
Authors: Bhandari Sunil , Pereira Dora I. A. , Chappell Helen F. , Drakesmith Hal
Published: August 2018

Iron is an essential trace mineral necessary for life, and iron deficiency anaemia (IDA) is one of the most common haematological problems worldwide, affecting a sixth of the global population. Principally linked to poverty, malnutrition and infection in developing countries, in Western countries the pathophysiology of IDA is primarily linked to blood loss, malabsorption and chronic disease. Oral iron replacement therapy is a simple, inexpensive treatment, but is limited by gastrointestinal side effects that are not inconsequential to some patients and are of minimal efficacy in others. Third generation intravenous (IV) iron therapies allow rapid and complete replacement dosing without the toxicity issues inherent with older iron preparations. Their characteristic, strongly-bound iron-carbohydrate complexes exist as colloidal suspensions of iron oxide nanoparticles with a polynuclear Fe(III)-oxyhydroxide/oxide core surrounded by a carbohydrate ligand. The physicochemical differences between the IV irons include mineral composition, crystalline structure, conformation, size and molecular weight, but the most important difference is the carbohydrate ligand, which influences complex stability, iron release and immunogenicity, and which is a unique feature of each drug. Recent studies have highlighted different adverse event profiles associated with third-generation IV irons that reflect their different structures. The increasing clinical evidence base has allayed safety concerns linked to older IV irons and widened their clinical use. This review considers the properties of the different IV irons, and how differences might impact current and future clinical practice.
Outcomes When Using Adjunct Dexmedetomidine with Propofol Sedation in Mechanically Ventilated Surgical Intensive Care Patients
Authors: Louie Jessica M. , Lonardo Nick W. , Mone Mary C. , Stevens Vanessa W. , Deka Rishi , Shipley Wayne , Barton Richard G.
Published: August 2018

Objective: Compare the duration of mechanical ventilation between patients receiving sedation with continuous infusions of propofol alone or combination with the use of dexmedetomidine and propofol. Design: Retrospective, propensity matched (1:1) cohort study, employing eight variables chosen a priori for matching. Timing of exposure to dexmedetomidine initiation was incorporated into a matching algorithm. Setting: Level 1, university-based, 32-bed, adult, mixed trauma and surgical intensive care unit (SICU). Continuous sedation was delivered according to a protocol methodology with daily sedation vacation and spontaneous breathing trials. Choice of sedation agent was physician directed. Patients: Between 2010 and 2014, 149 SICU patients receiving mechanical ventilation for >24 h received dexmedetomidine with propofol. Propensity matching resulted in 143 pair cohorts. Interventions: Dexmedetomidine with propofol or propofol alone. Measurements and Main Results: There was no statistical difference in SICU length of stay (LOS), with a median absolute difference of 5.3 h for propofol alone group (p = 0.43). The SICU mortality was not statistically different (RR = 1.002, p = 0.88). Examining a 14-day period post-treatment with dexmedetomidine, on any given day (excluding days 1 and 14), dexmedetomidine with propofol-treated patients had a 0.5% to 22.5% greater likelihood of being delirious (CAM-ICU positive). In addition, dexmedetomidine with propofol-treated patients had a 4.5% to 18.8% higher likelihood of being above the target sedation score (more agitated) compared to propofol-alone patients. Conclusions: In this propensity matched cohort study, adjunct use of dexmedetomidine to propofol did not show a statistically significant reduction with respect to mechanical ventilation (MV) duration, SICU LOS, or SICU mortality, despite a trend toward receiving fewer hours of propofol. There was no evidence that dexmedetomidine with propofol improved sedation scores or reduced delirium.
Perspectives on Natural Philosophy
Authors: Salthe Stanley N.
Published: August 2018

This paper presents a viewpoint on natural philosophy focusing on the organization of substance, as well as its changes as invited by the Second Law of thermodynamics. Modes of change are pointed to as definitive of levels of organization; these include physical, chemical, and biological modes of change. Conceptual uses of the subsumptive hierarchy format are employed throughout this paper. Developmental change in dissipative structures is examined in some detail, generating an argument for the use of final causality in studies of natural systems. Considerations of ‘internalism’ in science are presented along the way.
The Effect of Thermo-Chemical Treatment on the Water Resistance of Defatted Soybean Flour-Based Wood Adhesive
Authors: Zhang Binghan , Li Jin , Kan Yufei , Gao Jianfang , Zhang Yuehong , Gao Zhenhua
Published: August 2018

The aim of this study was to effectively improve the water resistance of a defatted soybean flour (DSF)-based adhesive by subjecting DSF to thermo-chemical treatment in the presence of sodium dodecyl sulfate (SDS), and then the crosslinking with epichlorohydrin-modified polyamide (EMPA). The effect of thermo-chemical treatment on the structures and properties of the DSF and DSF-based adhesive were investigated by plywood evaluation, boiling-water-insoluble content, and acetaldehyde value measurements, as well as FTIR, X-ray photoelectron spectroscopic (XPS), X-ray diffraction spectroscopy (XRD), thermogravimetric analysis (TGA), and rheology analyses. The test results revealed that the water resistance of the DSF-based adhesive was significantly improved, attributed to the formation of a solid three-dimensional crosslinked network structure resulted from the repolymerization of DSF, the Maillard reaction between the protein and carbohydrate, and chemical crosslinking between the crosslinker and DSF. Moreover, SDS destroyed the hydrophobic interactions within protein and inhibited macromolecular aggregations during the thermal treatment. Therefore, more reactive groups buried within the globular structure of the soybean protein component of DSF could be released, which supported the repolymerization, Maillard reaction, and chemical crosslinking of DSF, thereby leading to an improved crosslinking density of the cured DSF-based adhesive. In addition, the adhesive composed of thermo-chemically treated DSF and EMPA exhibited preferable viscosity and viscosity stability suitable for the production of wood composites.
Detection of Leak-Induced Pipeline Vibrations Using Fiber—Optic Distributed Acoustic Sensing
Authors: Stajanca Pavol , Chruscicki Sebastian , Homann Tobias , Seifert Stefan , Schmidt Dirk , Habib Abdelkarim
Published: August 2018

In the presented work, the potential of fiber-optic distributed acoustic sensing (DAS) for detection of small gas pipeline leaks (<1%) is investigated. Helical wrapping of the sensing fiber directly around the pipeline is used to increase the system sensitivity for detection of weak leak-induced vibrations. DAS measurements are supplemented with reference accelerometer data to facilitate analysis and interpretation of recorded vibration signals. The results reveal that a DAS system using direct fiber application approach is capable of detecting pipeline natural vibrations excited by the broadband noise generated by the leaking medium. In the performed experiment, pipeline vibration modes with acceleration magnitudes down to single μg were detected. Simple leak detection approach based on spectral integration of time-averaged DAS signals in frequency domain was proposed. Potential benefits and limitations of the presented monitoring approach were discussed with respect to its practical applicability. We demonstrated that the approached is potentially capable of detection and localization of gas pipeline leaks with leak rates down to 0.1% of the pipeline flow volume and might be of interest for monitoring of short- and medium-length gas pipelines.
Femtosecond-Pulsed Laser Written and Etched Fiber Bragg Gratings for Fiber-Optical Biosensing
Authors: Schulze Sven , Wehrhold Michel , Hille Carsten
Published: August 2018

We present the development of a label-free, highly sensitive fiber-optical biosensor for online detection and quantification of biomolecules. Here, the advantages of etched fiber Bragg gratings (eFBG) were used, since they induce a narrowband Bragg wavelength peak in the reflection operation mode. The gratings were fabricated point-by-point via a nonlinear absorption process of a highly focused femtosecond-pulsed laser, without the need of prior coating removal or specific fiber doping. The sensitivity of the Bragg wavelength peak to the surrounding refractive index (SRI), as needed for biochemical sensing, was realized by fiber cladding removal using hydrofluoric acid etching. For evaluation of biosensing capabilities, eFBG fibers were biofunctionalized with a single-stranded DNA aptamer specific for binding the C-reactive protein (CRP). Thus, the CRP-sensitive eFBG fiber-optical biosensor showed a very low limit of detection of 0.82 pg/L, with a dynamic range of CRP detection from approximately 0.8 pg/L to 1.2 µg/L. The biosensor showed a high specificity to CRP even in the presence of interfering substances. These results suggest that the proposed biosensor is capable for quantification of CRP from trace amounts of clinical samples. In addition, the adaption of this eFBG fiber-optical biosensor for detection of other relevant analytes can be easily realized.
Probabilistic Generalization of a Comprehensive Model for the Deterioration Prediction of RC Structure under Extreme Corrosion Environments
Authors: Zhu Xingji , Chen Zaixian , Wang Hao , Chen Yabin , Xu Longjun
Published: August 2018

In some extreme corrosion environments, the erosion of chloride ions and carbon dioxide can occur simultaneously, causing deterioration of reinforced concrete (RC) structures. This study presents a probabilistic model for the sustainability prediction of the service life of RC structures, taking into account that combined deterioration. Because of the high computational cost, we also present a series of simplifications to improve the model. Meanwhile, a semi-empirical method is also developed for this combined effect. By probabilistic generalization, this simplified method can swiftly handle the original reliability analysis which needs to be based on large amounts of data. A comparison of results obtained by the models with and without the above simplifications supports the significance of these improvements.
Potential Recovery Assessment of the Embodied Resources in Qatar’s Wastewater
Authors: Alsheyab Mohammad A. T. , Kusch-Brandt Sigrid
Published: August 2018

Due to the ever-growing demand for natural resources, wastewater is being considered an alternative source of water and potentially other resources. Using Qatar as an example, this study assesses the resources embodied in wastewater and paves the way to combine wastewater treatment with advanced resource recovery (water, energy, nitrogen, phosphorous, added value products) which can turn wastewater management from a major cost into a source of profit. In this sense, wastewater is no longer seen as a problem in need of a solution, rather it is part of the solution to challenges that societies are facing today. Based on estimated quantities of generated urban wastewater and its average composition, mass flow analysis is implemented to explore the maximum availability of major wastewater constituents (solids, organic compounds, nutrients, chloride, alkalinity, sulfide). An assessment analysis reveals that, in Qatar, more than 290,000 metric tons total solids, 77,000 metric tons organic compounds, 6000 metric tons nitrogen, 81,000 metric tons chloride, 2800 metric tons sulfide, and 880 metric tons of phosphorus are embedded in about 176 million m3 of urban wastewater annually. One promising valorization strategy is the implementation of anaerobic digestion with biogas production, and the organic materials contained in Qatar’s wastewater corresponds to more than 27 million m3 of methane (equivalent to an energy content of more than 270 GWh) per year. The results further suggest that the recovery of nitrogen, phosphorus, and sulfide should be given priority.
Religious Travellers’ Improved Attitude towards Nature
Authors: Robina Ramírez Rafael , Pulido Fernández Manuel
Published: August 2018

Pilgrimage is one of the most ancient forms of tourism. Nowadays, it is becoming a mass phenomenon that can lead to serious problems of environmental degradation in valuable sites. In this work, we have analysed by means of a structural equation model how religious consciousness is inspired in the religiosity/spirituality of each pilgrim. It could predict its effects on tourists regarding an improved (i.e., sensitised and more sustainable) attitude towards nature. The study was carried out in Guadalupe, Spain, which is a commonly known pilgrimage destination since 1389. A total of 203 visitors were surveyed using a questionnaire composed of 16 questions, divided into 4 dimensions (enriched attitudes toward nature, religious consciousness, sustainable development, and environmental human development), which were used as constructs in the model. The results showed how religious consciousness positively influences sustainable development (β = 0.657, t = 11.306) and environmental human development (β = 0.566, t = 8.255) explaining 75.6% of religious travellers’ more sensitive attitudes towards nature. Our findings suggest that a deeper research, on the role played by religiosity as a seed of fostering sustainability, is still needed.
Forest Adaptation to Climate Change along Steep Ecological Gradients: The Case of the Mediterranean-Temperate Transition in South-Western Europe
Authors: Fernández-Manjarrés Juan F. , Ruiz-Benito Paloma , Zavala Miguel A. , Camarero J. Julio , Pulido Fernando , Proença Vânia , Navarro Laetitia , Sansilvestri Roxane , Granda Elena , Marqués Laura , Temunovič Martina , Bertelsmeier Cleo , Drobinski Philippe , Roturier Samuel , Benito-Garzón Marta , Cortazar-Atauri Iñaki García de , Simon Laurent , Dupas Stephane , Levrel Harold , Sautier Marion
Published: August 2018

Impacts of climate change are likely to be marked in areas with steep climatic transitions. Species turnover, spread of invasive species, altered productivity, and modified processes such as fire regimes can all spread rapidly along ecotones, which challenge the current paradigms of ecosystem management. We conducted a literature review at a continental-wide scale of South-Western European forests, where the drier and warmer conditions of the Mediterranean have been widely used as examples of what is expected in more temperate areas. Results from the literature point to: (a) an expansion of slow-growing evergreen hardwood trees; (b) increased dieback and mortality episodes in forests (both natural and planted) mostly related to competition and droughts, and mainly affecting conifers; and (c) an increase in emergent diseases and pests of keystone-trees used in agroforestry zones. There is no consensus in the literature that fire regimes are directly increasing due to climate change, but available satellite data of fire intensity in the last 17 years has been lower in zones where agroforestry practices are dominant compared to unmanaged forests. In contrast, there is agreement in the literature that the current spread of fire events is probably related to land abandonment patterns. The practice of agroforestry, common in all Mediterranean countries, emerges as a frequent recommendation in the literature to cope with drought, reduce fire risk, and maintain biodiverse landscapes and rural jobs. However, it is unknown the extent to which the open vegetation resulting from agroforestry is of interest to forest managers in temperate areas used to exploiting closed forest vegetation. Hence, many transitional areas surrounding the Mediterranean Basin may be left unmanaged with potentially higher climate-change risks, which require active monitoring in order to understand and help ongoing natural adaptation processes.
Housing Vulnerability and Property Prices: Spatial Analyses in the Turin Real Estate Market
Authors: Barreca Alice , Curto Rocco , Rolando Diana
Published: August 2018

In the literature, several vulnerability/resilience indicators and indexes are based and assessed by taking into account and combining different dimensions. Housing vulnerability is one of these dimensions and is strictly related to the buildings’ physical features and to the socio-economic condition of their occupants. This research aims to study housing vulnerability in relation to the real estate market by identifying possible indicators and spatially analyzing their influence on property prices. Assuming the city of Turin and its territorial segmentation as a case study, spatial analyses were performed to take into account the presence of spatial dependence and to identify the variables that significantly influence the process of property price determination. The results of this study highlighted the fact that two housing vulnerability indicators, representative of fragile buildings’ physical features, were spatially correlated with property prices and had a significant and negative influence on them. In addition, their comparison with two social vulnerability indicators demonstrated that the presence of economical buildings and council houses was spatially correlated with the presence of people with a low education level. The results of the spatial regression model also confirmed that one of the social vulnerability indicators had the highest and most negative explanatory power in the property price determination process.
Classical Swine Fever Virus p7 Protein Interacts with Host Protein CAMLG and Regulates Calcium Permeability at the Endoplasmic Reticulum
Authors: Gladue Douglas P. , Largo Eneko , Holinka Lauren G. , Ramirez-Medina Elizabeth , Vuono Elizabeth A. , Berggren Keith A. , Risatti Guillermo R. , Nieva Jose L. , Borca Manuel V.
Published: August 2018

We have previously shown that Classical Swine Fever Virus (CSFV) p7 is an essential nonstructural protein with a viroporin activity, a critical function in the progression of virus infection. We also identified p7 domains and amino acid residues critical for pore formation. Here, we describe how p7 specifically interacts with host protein CAMLG, an integral ER transmembrane protein involved in intracellular calcium release regulation and signal response generation. Detection of interaction as well as the identification of p7 areas mediating interaction with CAMLG was performed by yeast two-hybrid. p7-CAMLG interaction was further confirmed by confocal microscopy in eukaryotic cells, co-expressing both proteins. Mutant forms of p7 having substituted native residues identified as mediating interaction with CAMLG showed a decreased co-localization compared with the native forms of p7. Furthermore, it is shown that native p7, but not the mutated forms of p7 that fail to interact with CAMLG, efficiently mediates calcium permeability in the ER. Interestingly, viruses harboring some of those mutated forms of p7 have been previously shown to have a significantly decreased virulence in swine.
Improved Inverse Modeling by Separating Model Structural and Observational Errors
Authors: Cheng Qin-Bo , Chen Xi , Cheng Dan-Dan , Wu Yan-Yan , Xie Yong-Yu
Published: August 2018

A practical formal likelihood function (L) is developed to separate model structure errors and observation errors by the separation of correlated and uncorrelated model residuals. L overcomes the time-consuming problem of likelihood functions proposed by previous studies, and combines the Mean Square Error (MSE) and first-order Auto-Regression (AR(1)) models. For comparison of the effect of different error models, MSE, AR(1), and L are used as efficiency criteria to calibrate the three-dimensional variably saturated ground-water flow model (MF2K-VSF) based on the soil tank seepages of rainfall–runoff experiments. Results of L are nearly the same as those of AR(1) due to negligible observational errors. Although all calibrated models well mimic the seepage discharges, MF2K-VSF with MSE cannot capture the groundwater level and soil suction processes because of the considerable autocorrelation of model residuals owing to model inadequacies (e.g., neglect of the soil moisture hysteresis), which obviously violates the statistical assumption of MSE. By contrast, L accounts for the model structural errors and thus enhances the reliability of hydrological simulations.
Evolution of the general practice pharmacist’s role in England: a longitudinal study
Authors: Bradley Fay , Seston Elizabeth , Mannall Ceinwen , Cutts Chris
Published: August 2018

Background

To address the growing GP workforce crisis, NHS England (NHSE) launched the Clinical Pharmacists in General Practice scheme in 2015. The NHSE scheme promotes a newer, patient-facing role for pharmacists and, currently, there is little insight into the role and activities undertaken. All scheme pharmacists are enrolled on the general practice pharmacist training pathway (GPPTP).

Aim

To investigate the role evolution and integration of clinical pharmacists in general practice in England.

Design and setting

Longitudinal survey of all phase 1 GPPTP registrants working in general practice at start of (T1) and 6 months into (T2) training.

Method

An online longitudinal survey was administered to all phase 1 GPPTP registrants (n = 457) at T1 and T2, measuring their perceived knowledge, skill, and confidence, activities performed, and perceptions of practice integration, environment, and support. Descriptive statistics and non-parametric tests were conducted.

Results

Response rates were 46% (T1) and 52% (T2); 158 participants completed both questionnaires. Perceived knowledge, skill, and confidence levels increased significantly from T1 to T2 for all areas, except for managing acute or common illness. Scope of practice increased significantly, particularly in patient-facing activities. Sharing office space with administrative staff was common and 13% of participants reported having no designated work area. Perceived integration at T2 was fairly high (median = 5 on a scale of 1–7) but GP clinical support was ‘too little’ according to one-third of participants.

Conclusion

Findings show not only patient-facing role expansion, but also practice environment and support issues. Pharmacists may appreciate more GP time invested in their development. Practices need to be realistic about this support and not expect an immediate reduction in workload.