bluuebunny/crossref_metadata_2025 huggingface dataset:
High resolution X-ray microtomography as a tool for observation and classification of individual microplastics
Authors: Teles Átila de Paiva , Santos da Silva Marcus Vinicius , Ferreira de Oliveira Davi , Tadeu Lopes Ricardo
Published: January 2025

Plastics are synthetic polymers, widely used due to their durability, resistance, and lightweight properties. However, their extensive production and long-lasting nature have led to environmental challenges, notably the accumulation of plastic waste, where they degrade into microplastics (MPs)—particles smaller than 5 mm. These MPs contaminate various ecosystems, including water bodies, soils, and even the atmosphere. Understanding the complex structures of MPs is essential, but their heterogeneity makes characterization challenging. This study investigates the use of X-ray microtomography (microCT) as a tool for characterizing MPs. By scanning plastic fragments embedded in sediment, microCT provides detailed internal and external morphological data in a non-destructive manner. The total volume measured by microCT was approximately 150.00 mm³, accounting for 79% of the estimated theoretical volume, with a total surface area of 1061.00 mm². The analysis focused on morphometric parameters such as Feret diameter, anisotropy degree, and sphericity, which describe the shape and symmetry of individual particles. Results indicated significant variability in these parameters, reflecting the diverse nature of MPs. Additionally, microCT imaging detected slight variations in material composition, indicating potential heterogeneity within the polymers. The study highlights the need for standardization in MP classification and suggests that microCT, with its ability to detect subtle variations in material composition, holds promise for future environmental research. Further exploration of microCT's capabilities could enhance our understanding of MP behavior and impact, particularly in relation to their composition and environmental interactions.
Modern Management Approaches for Alopecia Areata
Authors: Ambarchyan Eduard T. , Ivanchikov Vladislav V. , Alekseeva Anastasiya D. , Gordeeva Olga B. , Namazova-Baranova Leyla S.
Published: January 2025

Alopecia areata is a chronic genetically determined inflammatory autoimmune disease damaging hair follicles and leading to temporary or persistent nonscarring hair loss. Janus kinase inhibitors have been registered for its management, it allows to personalize the therapy and increase its efficacy by relieving symptoms and positively affecting patients’ quality of life. This group of drugs is considered as the basic one for the treatment of alopecia areata severe forms. The issue of disease relapses after Janus kinase inhibitors cessation and safety of long-term therapy with such drugs are covered.
DUBR/miR-17-3p/TFRC/HO-1 Axis Promotes the Chemosensitivity of Multiple Myeloma
Authors: Guo Tao , Zhang Feng , Wang Hongfang , Li He , Xia Meihua , Niu Xiaoxiao
Published: January 2025

Long non-coding RNAs (lncRNAs) are intensively involved in the pathogenesis of multiple myeloma (MM). The purpose of this study was to investigate the potentials of DUBR in MM. Gene expression was determined using RT-qPCR and western blot. The release of ROS, MDA, ferrous iron, and GSH was detected with corresponding assays. Cell behavior was detected using CCK-8, colony formation, transwell, and PI staining assays. The binding sites between miR-17-3p and DUBR/TFRC was verified firmed by RIP, RNA pull-down, as well as luciferase assays. We found that low levels of DUBR predicted poor prognosis of MM patients. However, overexpressed DUBR enhanced the chemosensitivity of MM cells to bortezomib (BTZ), as well as promoted the ferroptosis of MM cells. DUBR sponged miR-17-3p to upregulate TFRC. However, TFRC knockdown abrogated the effects of overexpressed DUBR and promoted the aggressiveness of MM cells. In summary, DUBR promotes the chemosensitivity of MM cells to BTZ via regulating miR-17-3p/TFRC axis. Therefore, targeting DUBR may be a potential target for MM.
SOP ANALYSIS OF DF RELAYING-ENABLED SWIPT-NOMA NETWORK WITH DIFFERENT JAMMING CONDITIONS
Authors: Reddy D. Kumar , Nayak V. Narasimha , Rohan D. B. S. , Sridhar P. Naga
Published: January 2025

This work addresses the improvement of secrecy outage probability (SOP) in an energy-harvesting non-orthogonal multiple-access (NOMA) network featuring simultaneous wireless information and power transfer (SWIPT) under Rayleigh fading environment. The primary objective is to minimize the SOP in the decode-and-forward (DF) relaying-aided downlink NOMA network using a power-splitting protocol, considering the presence of an untrusted intruder, while ensuring the user's quality-of-service in an environment with perfect successive interference cancellation. Furthermore, this work introduces various jammer techniques to enhance the security performance of the SWIPT-NOMA network. Additionally, the impact of critical parameters, such as the signal-to-noise ratio, as well as the distances between different nodes, such as dje, dse, and dsu1, on SOP levels is also investigated under different jamming scenarios. The proposed schemes are validated through Monte-Carlo-based simulation results, demonstrating the superior efficacy of a control jammer in enhancing secrecy performance.
Progress in the development of NiO/MgO solid solution catalysts: a review
Authors: Chen Shaoqin , Hu Yun Hang
Published: January 2025

NiO/MgO solid solution materials have emerged as highly effective catalysts for various catalytic processes, including dry methane reforming, CO2 hydrogenation, methane partial oxidation, and steam reforming of hydrocarbons. The similar lattice parameters of NiO and MgO allow the formation of homogeneous solid solutions, where metallic Ni particles can be generated through the NiO reduction that is controlled by MgO isolation effect on NiO in the solid solution. The small size of these particles plays a crucial role in preventing carbon deposition and sintering in catalytic reactions. In this review, the basic principles of the formation of NiO/MgO solid solution, the reduction properties of the catalysts, and the insight into its high catalytic activity are elucidated. The synthesis methods of NiO/MgO solid solutions are presented. In addition, the recent progress of catalytic applications of NiO/MgO solid solutions is provided. By offering deep insights into solid solution catalysts, this review aims to facilitate their further development for diverse catalytic processes.
History of chloroform anesthesia in dentistry
Authors: Spielman Andrew I. , Forrai Judit
Published: January 2025

The discovery of chloroform as an anaesthetic agent occurred independently in 1831 by Samuel Guthrie in New York and Eugene Soubeiron in France. Between its discovery and the introduction of local anaesthesia, chloroform had limited usage in dentistry.
A dicotomia entre a revitalização urbana e o abandono de imóveis
Authors: Moura Mariana Pereira , Torres Daniel Henrique da Silva , Barbosa Ricardo Victor Rodrigues
Published: January 2025

This paper aims to discuss the problem of abandoned buildings from the perspective of sustainability. The theoretical article investigates the current situation of these buildings in the city, presenting the environmental, social, economic and cultural aspects. The analysis of the characteristics of the unsustainable urban environment helps to understand how the reuse of empty buildings and lots could promote urban sustainability. At the same time, urban revitalization processes expose a dichotomy, as they cause other problems relating to sustainable practice. The methodology used was based on the evaluation of three urban revitalization projects in former abandoned areas: Lx Factory, Wynwood and Porto Maravilha. The aim of the case studies is to explore the different contexts and scales of the projects, as well as to find congruent aspects through the application of the concept of sustainability and its relationship to both the problems seen with abandonment and the interventions that seek to undermine its effects.
A dinâmica do Transporte Público na Região Metropolitana de São Paulo
Authors: Daroncho Celio , Martinez Pedro José Perez
Published: January 2025

Urban Public Transport is essential for urban mobility and the sustainability of cities. In March 2020, the Covid-19 Pandemic began, forcing the decree of quarantines and lockdowns in almost all cities in the world, facts that abruptly interrupted urban mobility, generating significant drops in the demand for transport in urban areas. In São Paulo, the quarantine began on March 24, 2020, and ended on August 17, 2021, significantly impacting not only the use of Urban Public Transport, but in the urban mobility. This study analyses the monthly and annual volumes of passengers transported by public transport systems in the Metropolitan Region of São Paulo between 2017 and 2023, using the tools of basic descriptive statistics, such as mean, median, amplitude, asymmetry, and kurtosis, in addition to the graphical analysis of the distribution of the data series. The data show that the drop in demand, except for subway transport, has occurred since 2018, with a significant drop in the Pandemic with a gradual resumption from the second half of 2020, with 2023 still below 2017 levels, on average 27% in the urban bus system, 16% in the metropolitan bus system, 8% in the subway system and 24% in the urban train system. This study shows an apparent accommodation of data at this new level, which can greatly impact not only the financial health of companies, but in the total urban mobility.
Bifurcation Analysis and Multiobjective Nonlinear Model Predictive Control of Drug Addiction Models
Authors: Lakshmi N Sridhar
Published: January 2025

Bifurcation analysis and nonlinear model predictive control were performed on drug addiction models. Rigorous proof showing the existence of bifurcation (branch) points is presented along with computational validation. It is also demonstrated (both numerically and analytically) that the presence of the branch points was instrumental in obtaining the Utopia solution when the multiobjective nonlinear model prediction calculations were performed. Bifurcation analysis was performed using the MATLAB software MATCONT while the multi-objective nonlinear model predictive control was performed by using the optimization language PYOMO.
Treating Pediatric Asthma through Bonding Therapy
Authors: Antonio Madrid
Published: January 2025

Pediatric asthma affects more children than any other childhood disease. Causes have been linked to many factors, most noticeably maternal issues. Yatsenko, et al. 2016 [1] claim that bonding disruptions are at the heart of the majority of maternal factors.
Bonding disruptions were identified by Marshall Klaus and John Kennel, fitting into two primary categories: separation at birth and maternal distress. When either of these factors is present, a mother usually will not bond with her baby.
On Defining a Living Element as an Increment of Wave Energy to an Existing Particle-wave
Authors: Gregory L Light
Published: January 2025

This paper overall treats the timeless mind-body problem. Descartes said: “I think, therefore I am.” This suggests the existence of life in a non-material world, specifically, a spacetime that is devoid of particles, which then evokes the equally celebrated theme of the wave-particle duality, which is the foundation of quantum mechanics. Correspondingly in mathematics, there is a dichotomy of the real number 1, and the imaginary number i - - which has however presented itself as a mystery for centuries. Here, we maintain that a 1-dimensional manifold is either a line or otherwise with curvatures and any curvature can be locally fitted by a circle, i.e., either a line with unit 1 or a unit circle expressed by exp(it), such as in the contrast between a linear calendar time t and a circular clock time it, or a linear expansion versus a rotational motion as indicated by the eigenvalues of a linear operator in a dynamical system. As such, the imaginary number i is just a periodic motion, or a wave. While Maxwell’s electromagnetic wave has energy, the quantum wave is yet a probability; we unify these two treatments of the wave by equating the quantum wave with Maxwell’s electromagnetic wave. The wave-particle duality logically leads to a diagonal spacetime manifold containing {(particle, its associated electromagnetic wave)}. In literature, a particle wave has its energy E distributed into (3E/4, E/4) respectively. Experimentally, a 50/50 beam splitter has been found to split half of the E/4 into a particle-less wave, evidencing the existence of a separate but coincidental wave universe; it is here that we define a living element as a set of particle-less electromagnetic waves that adds life to a set of molecules in the particle universe. We will present the mathematical formulation of the above and examine its implications and applications.
Design, Optimization and In-vivo Characterization of Oral Fast Dissolving Films of Sertraline for Treatment of Postpartum Depression
Authors:   Department of Pharmaceutics, P. Rami Reddy Memorial College, Kadapa, 516004, Andhra Pradesh, India, Budarapu Divya , Bandela Jeevana Jyothi
Published: January 2025

Objectives: The main aim of the present study is to enhance solubility, oral bioavailability and minimize dose related side effects of Sertraline (STR) by using a novel approach. Methods: Different ratios of STR solid dispersions were prepared using PEG 4000 as a polymer. Evaluation studies were conducted to identify optimized formulation, and the selected optimized formulation was utilised for the preparation of oral fast dissolving films (OFDF). The OFDF formulations were fabricated using pullulan and PVA as a polymer by solvent casting method. Findings: Folding endurance, disintegration time, wetting time and in-vitro drug release studies were conducted to identify optimized formulation. It was found that OS3 showed optimum characteristics with sufficient disintegration time (42.16 sec), wetting time (20 sec) and high drug release of 94.42%. Novelty: It is evident that OFDF enhanced the oral bioavailability as well as therapeutic efficacy of an extensive first pass metabolic drug with poor water solubility.

Keywords: Solvent casting method, Oral Bioavailability, Solubility, Folding Endurance, Therapeutic Efficacy
Adjacency Sequence and Adjacency Spectrum of Power Fuzzy Graphs
Authors:   Research Scholar, Department of Mathematics, Loyola College, University of Madras, Chennai, 600034, Tamil Nadu, India, Paulin S Shiny , Bharathi T
Published: January 2025

Objectives: To find the adjacency sequence, spectrum of the power fuzzy graphs and discuss its properties. Methods: The spectrum and energy of the power fuzzy graphs are derived using the adjacency matrices. Energy of the power fuzzy graph is computed by adding the absolute eigenvalues of the adjacency matrix. Findings: The condition for a power fuzzy graph, 𝐺𝑓 𝑘 to be vertex regular in terms of adjacency sequence has been verified. The energy sequence for the power fuzzy graph with increasing 𝑘 has been established. Novelty: The concept of minimizing the interval of the edge membership values when the powers of fuzzy graph increase makes difference in the spectrum and energy of fuzzy graphs with the same initial structure. The concept of adjacency matrix, spectrum and energy of power fuzzy graph is applied in power supply load distribution system.

Keywords: Fuzzy graph; Power fuzzy graph; Adjacency sequence; Spectrum; Energy
Anatomy and biomechanics of posterolateral angle structures of the knee joint
Authors: Salikhov Marsel R. , Avramenko Vladislav V. , Batalov Gleb E. , Sannikova Ekaterina V.
Published: January 2025

BACKGROUND: Structural injuries of the posterolateral angle of the knee are rare. However, these conditions are characterized by high-energy etiologic mechanisms and cause rapidly progressive degenerative processes in the knee joint. There is currently no consensus on the need for reconstructing damaged posterolateral angle structures for effective knee stabilization with surgery. Understanding the effects of anatomical elements of the posterolateral angle on posterolateral knee rotational instability is of theoretical and practical importance.
AIM: The aim of this study was to evaluate anatomy and morphometry of the popliteal tendon and the fibular collateral ligament, including their zones of attachment to the femur and the role of these structures in the posterolateral rotational and frontal instability of the knee joint.
MATERIALS AND METHODS: A single-center comprehensive topographic and anatomical study used 50 unfixed anatomical specimens of the lower extremities (30 females, 20 males). The mean age was 30 to 60 years. Patients died from causes other than musculoskeletal disorders. Precise dissection of the posterolateral angle components (popliteus tendon and peroneal collateral ligament) was performed with detailed examination and documentation of the morphometric characteristics of the femoral attachment sites of the studied structures. The posterolateral angle structures were then sequentially dissected to determine their effect on posterolateral rotational instability and tibial varus deviation (varus stress test) and posterior tibial translation (posterior drawer test).
RESULTS: After dissection of the fibular collateral ligament, the maximum varus deviation of the knee joint was 5° ± 3.0°. A more significant external rotation of the tibia of 11.0° ± 1.5° was achieved after popliteal tendon release. The intersection of the posterior cruciate ligament resulted in a maximum posterior tibial displacement relative to the femur by 9 (7.9–10.2) mm.
CONCLUSIONS: This study evaluated in detail the anatomy and function of the posterolateral angle structures of the knee joint. The results obtained highlight the leading role of the popliteal tendon in the pathogenesis of posterolateral rotational instability and the fibular collateral ligament in the pathogenesis of the frontal (varus) instability of the knee joint, which is of great importance for the diagnosis and surgical treatment of these types of knee instability.
Desarrollo y liderazgo de las mujeres. Guía para promover la igualdad de género en las empresas de América Latina y el Caribe: dimensión 3
Authors: Avella Analia Marina , Hakspiel Julia , Villanueva María Teresa
Published: January 2025

Desarrollo y liderazgo de las mujeres es una de las ocho dimensiones de la Guía para promover la igualdad de género en las empresas de América Latina y el Caribe. Esta guía tiene como objetivo orientar al sector empresarial en el diseño e implementación de medidas que promuevan la igualdad de oportunidades entre hombres y mujeres en los entornos laborales. Incluye evidencia, herramientas de apoyo y casos de estudio tanto regionales como internacionales, además de ofrecer hojas de ruta claras con recomendaciones flexibles y adaptables a los diversos contextos y necesidades empresariales.
Guías de actuación regional para una respuesta coordinada frente a la trata de personas desde el sector de seguridad y justicia: guía introductoria
Authors: Peña Norma , Wolfenzon Denisse , Pérez Gallego Carlos Andrés , Borda Montenegro Angie , Osorto Velásquez Sindy Sirey , Piedra Vázquez Paúl Andrés
Published: January 2025

La trata de personas es un delito y una grave violación a los derechos humanos que afecta a millones de niños, niñas, mujeres y hombres en todo el mundo. Las “Guías de Actuación Regional para dar una Respuesta Coordinada a la Trata de Personas desde el Sector de Seguridad y Justicia”, elaboradas por la Oficina de las Naciones Unidas contra la Droga y el Delito (UNODC) y el Banco Interamericano de Desarrollo (BID), comprenden cinco documentos: la Guía introductoria, la Guía 1 sobre prevención de la TdP, la Guía 2 enfocada en investigación y judicialización, la Guía 3 relativa a la asistencia y protección de sobrevivientes, y la Guía 4 sobre cooperación internacional en la lucha contra la TdP. Esta Guía introductoria ofrece respuestas a preguntas frecuentes relacionadas con la trata de personas, como en qué consiste este delito, cuáles son sus finalidades y modalidades, y cómo se presenta en el contexto global y en América Latina y el Caribe. Además, identifica a las poblaciones afectadas y desmiente los mitos comunes que rodean a este delito. También describe enfoques clave para abordar la trata de manera integral, los cuales se desarrollan y aplican a lo largo de las guías posteriores.
Diseño inclusivo de productos y servicios. Guía para promover la igualdad de género en las empresas de América Latina y el Caribe: dimensión 7
Authors: Avella Analia Marina , Hakspiel Julia , Villanueva María Teresa
Published: January 2025

Diseño inclusivo de productos y servicios es una de las ocho dimensiones de la Guía para promover la igualdad de género en las empresas de América Latina y el Caribe. Esta guía tiene como objetivo orientar al sector empresarial en el diseño e implementación de medidas que promuevan la igualdad de oportunidades entre hombres y mujeres en los entornos laborales. Incluye evidencia, herramientas de apoyo y casos de estudio tanto regionales como internacionales, además de ofrecer hojas de ruta claras con recomendaciones flexibles y adaptables a los diversos contextos y necesidades empresariales.
Burnout in Healthcare Professionals during Covid-19 Crisis
Authors: Kashgsaray Nasim Hajipoor , Soleimanpour Maryam , Behmanesh Sina , Soleimanpour Hassan
Published: January 2025

Background: Since 2019, the COVID-19 disease has led to the death and disability of many people all over the world and the treatment staff has been providing services around the clock. Therefore, psychological burnout among them is highly possible. So far, no study has compared the incidence of mental burnout between doctors and nurses in the emergency department. This study has compared the psychological burnout between doctors and nurses during COVID-19 at the emergency department.
Methods: This cross-sectional study included 67 doctors and nurses working in the Emergency Department of Imam Reza Hospital of Tabriz University of Medical Sciences who had been working there during the COVID-19 outbreak. The instrument of study was the standard Copenhagen psychological burnout questionnaire. After obtaining the written consent, the questionnaire was distributed among the doctors and nurses of the emergency department. The data was graded by Excel software and data analysis was conducted by SPSS V. 22 software.
Results: According to the comparison of the high burnout rate in the Copenhagen burnout scale, 50% of doctors and 57.1% of nurses had personal burnout, 56.8% of doctors and 66.7% of nurses had work-related burnout, 69.4% of doctors and 69% of nurses had patient-related burnout, and the overall rate of high burnout in doctors was reported as 62.9% and nurses as 70.4%. There was no statistically significant difference in personal burnout between emergency department physicians and nurses.
(P= 0.347). As well, there was not a significant statistical difference in terms of work-related, patient-related, and overall burnouts between the two groups (P= 0.066), (P= 0.696), and (P= 0.108). Yet, Regarding the distribution of genders between the two groups, there was a statistically significant difference (P= 0.001).
Conclusion: The level of mental burnout of doctors and nurses employed in the Emergency Department of Imam Reza General Hospital during the COVID-19 crisis was at an average high. Thus, improving the conditions of medical environments in health centers can reduce the burnout of working doctors and nurses, especially during epidemic conditions, which will increase the quality of medical services.
Assessment of the Logical Prescription of Albumin Drug According to Guideline and Patient Safety for Inpatients in Intensive Care Units of Iranian Hospital: A Cross-Sectional Study
Authors: Dashti Naghme , Hosseinjani Hesamoddin , Eslami Saeid , Tabatabaei Seyed Mohammad , Arki Hasan Vakili
Published: January 2025

Background: Medication errors in healthcare settings, including outpatient and hospital environments, pose a significant risk to patient safety. These errors can arise from incorrect dosages, drug interactions, contraindications, or inappropriate drug combinations.
Methods: This study aimed to assess the logical prescription of albumin according to guidelines and patient safety for inpatients in the intensive care units of Imam Reza Hospital in Mashhad through a cross-sectional study. Methods: Data were collected over a 3-month period from albumin prescriptions in intensive care units, using a checklist based on information from prescription forms, patient files, and consultations.
Results: The study found that 60.57% of albumin prescriptions were reviewed by DUE unit, with 51.53% complying with guidelines and 48.47% not. The highest prescription rate was in the Intensive Care Unit of Heart Surgery (ICUOH), at 36.83%, and the lowest in the Neonatal Intensive Care Unit (NICU), at 0.63%. The patient safety parameter, calculated based on correct/incorrect albumin prescriptions according to guidelines, showed an average safety of 67.10% across prescribing units and 62.34% based on indications. It reduced the financial burden caused by inappropriate prescriptions approximately $21,390 through DUE process.
Conclusion: The research highlights the importance of continuous guideline-base DUE on rational drug utilization, patient safety and hospitals costs.
Promotion Strategy for the Village Digidarpa Digital Information System for District-level Governments in Central Java Province
Authors: Socawangi Venus Pulung , Barlian Yelly Andriani , Taharuddin Nurul Shima , Nurbani Sri
Published: January 2025

Digidarpa Desa is an integrated digital information system product that can help villages improve the status of the Developing Village Index (IDM). Villages with advanced IDM status are considered more ready to adopt the Digidarpa Desa information system, both in terms of their needs and their technological readiness. Central Java Province has an average Advanced IDM status; therefore, the target audience for this promotion strategy is district governments in Central Java Province. This research was carried out using qualitative methods. The purpose of this research is to find the right promotion strategy for the digital information system product Digidarpa Desa for district-level governments in Central Java Province.
Keywords: application, business to business (B2B), developing village index (IDM), integration, village information system (SID)
The Motives behind the Skepticism of Conventional Medicine Advocates towards Traditional Persian Medicine: An Expert Opinion
Authors: Nimrouzi Majid , Salehi Zahra , Alembizar Faranak
Published: January 2025

The conflict between conventional medicine and traditional medicine is an issue worldwide. Various factors contribute to this dissent. In our study, we have explained that there are several denunciations about traditional medicine mentioned by proponents of conventional medicine. A search of important databases utilized related keywords to describe this purpose. Furthermore, the main Persian medicine resources were reviewed. Some critiques are because of a knowledge gap between ontology and epistemology of complementary medical approaches and conventional medicine. The other issue is the inadequate self-presentation of traditional medicine modalities to unwrap its obscure points for contemporary paradigm advocates to promote its points of strength. Traditional and conventional medicine share many abilities, but they cannot address all healthcare requirements alone. If we delineate medicine as a distinct system, it is a knowledge-based art for palliating physical and mental pains, and the traditional/conventional classification of medicine and separating these two schools is the first terrible impediment. It is believed by many that personalized medicine improves the management of patients. To achieve medicine's true objective - preserving and restoring health - we should move towards integrative medicine and validate patients' priorities and human values. The objective of this viewpoint is to enhance health awareness in both academia and the public sphere.
Factors Associated with the Utilization of Traditional Health Services among People with Non-Communicable Diseases in Indonesia: Findings from a Nationwide Survey
Authors: Suandana Iwan Abdi , Astuti Putu Ayu Swandewi , Januraga Pande Putu
Published: January 2025

Globally, there is an increasing trend of morbidity and mortality from non-communicable diseases (NCDs). Traditional health service is one of the new approaches to support NCDs program. This study aimed to determine the prevalence and factors associated with the use of traditional health services among people with NCDs in Indonesia. We conducted a secondary analysis of integrated nationwide health and socio-economic survey data in 2018. Of the 127,198 people with NCDs included in the analysis, 38.7% of people with NCDs have ever used traditional health services, with the most common type being those that involve manual therapies. Compared to the reference group, likelihood of higher utilization of the traditional health service was among those aged 45-54 years (adjusted odds ratio (AOR) 1.19; p <0.001), from highest socioeconomic (AOR = 1.13, p <0.001), employed (AOR> 1, p <0.05), married/divorced (AOR> 1, p <0.001), has two type of NCDs (AOR 1.06, p 0.023), knows the existence of the nearest doctor/clinic (AOR 1.36, p <0.001) and hospital (AOR = 1.13, p 0.002) and has very easy access to health facility (AOR 1.34, p <0.001). Better socialization of traditional health services especially to the groups who have low utilization is important. The information should include the availability of traditional health services types, benefits, and advantages of using these services. It is also necessary to improve the quality and standardization of traditional health services to enhance public trust and increase the utilization of the services. Since a certain proportion of people with NCDs rely on traditional health services, improvement of the traditional health services quality is crucial, as well as engagement of these services to NCDs programs.
Plasma Metabolite Profiles of Healthy Volunteers after Administration of a Thai Herbal Formula for Dizziness
Authors: Boonrak Ranida , Pilakasiri Kajee , Booranasubkajorn Suksalin , Lumlerdkij Natchagorn , Akarasereenont Pravit
Published: January 2025

The Thai herbal Yahom 20 formula (YHF20), is traditionally used for dizziness and fainting and off-label use for sleep aid, with inadequate substantial evidence afterward. This study’s primary objective is to employ metabolomics to investigate YHF20's effects, comparing it with lorazepam and a placebo in healthy volunteers. Phytochemical and metabolite profiling were performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and LC/MS Q-ToF, respectively, on plasma samples from 90 healthy participants aged 20 to 60 years. These participants were randomized into three groups: YHF20 (n=30), Lorazepam (n=30), and Placebo (n=30). Principal Component Analysis (PCA) and Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) were then conducted to identify differential metabolites and pathways. Six phytochemicals, including ellagic acid, glycyrrhizic acid, (E)-ferulic acid hexacosyl ester, 6-aldehydo-7-methoxy-isoophiopogonone B, melianol, and myristic acid were identified in YHF20. Despite PCA showing no significant overall metabolite profile differences among the groups, OPLS-DA pinpointed eight YHF20-associated metabolites, such as DHA ethyl ester, α-linolenic acid, (9Z)-9-octadecenamide, ricinoleic acid methyl ester, idazoxan, 13-HPODE, 12,13-DiHODE, and myristoleic acid, implying at anti-inflammatory pathway involvement, especially in α-linoleic and linoleic acid metabolism. No direct impact on sleep-related metabolites was found, the anti-inflammatory effects suggested by YHF20 could indirectly improve sleep quality by mitigating inflammation, a common sleep disruptor. These results highlight YHF20's potential for enhancing life quality through anti-inflammatory mechanisms. They offer a scientific basis for its traditional and anecdotal uses and suggest a novel approach to sleep quality improvement not previously documented.
Ginkgo biloba L.: An Updated Review on the Pharmacological Activities, Pharmacokinetics and Drug Interactions
Authors: Moeinipour Zahra , Akaberi Maryam , Sobhani Zahra
Published: January 2025

Medicinal herbs have recently received considerable public attention for their therapeutic properties. Traditional healing systems such as Ayurveda, traditional Chinese medicine, and traditional Persian medicine highly rely on medicinal plants to treat many diseases. However, herbal medicines are usually not standardized and despite their widespread use, there is limited scientific evidence on their safety and interactions. Ginkgo biloba L. is a medicinal plant whose biological properties have been confirmed in previous studies. Its leaf extract exhibited anti-inflammatory, antioxidant, neuroprotective, and anti-apoptotic properties. Nevertheless, G. biloba contains various pharmacologically active components, such as terpene lactones and flavonoids that could cause drug interactions through multiple mechanisms, including the effect on cytochrome isozymes and p-glycoprotein (P-gp). Thus, conducting studies to evaluate this plant's safety profile and drug interactions seems necessary. In the current paper, we reviewed the pharmacokinetics, drug interactions, and pharmacological properties of G. biloba plant. According to the included studies, bioactive compounds found in G. biloba extract have antagonistic activity against platelet aggregation and could inhibit human thrombin, thereby increasing the risk of severe bleeding. We also identified several other potential drug interactions for G. biloba, including risperidone, thiazides, mycophenolic acid, and diltiazem. Data on drug interactions between G. biloba and digoxin, simvastatin, nicardipine, and midazolam were less consistent. Therefore, caution should be taken in consuming this plant with anticoagulants or platelet inhibitors such as warfarin, ticlopidine, clopidogrel, and aspirin. However, patients’ age, gender, and dosage forms of medicine seem to play an essential role in drug interactions. In summary, further clinical and laboratory research is necessary to elucidate the risk of G. biloba drug interactions. Also, the use of technologies such as genomics, metabolomics, and transcriptomics can provide a more comprehensive understanding of how G. biloba interacts with drugs at the molecular level.
Examining the Relationship Between Fear of Childbirth During Pregnancy and Prenatal Attachment
Authors: Sari Tuğba , Gürhan Nermin
Published: January 2025

OBJECTIVE:Giving birth is one of the most stressful events in many women's lives. Fear of childbirth is common among pregnant women, also it becomes a serious issue if it affects daily life. Psychological problems such as fear of birth in pregnancy negatively affect prenatal bonding. The aim of this study is to investigate the relationship between fear of birth and prenatal attachment in pregnancy and examine the risk factors.

METHODS:The sample of the study consisted of 500 pregnant women at 20 and above weeks of gestation. Descriptive statistics (percentage, mean, standard deviation), independent groups t test, One Way ANOVA, Pearson correlation and multiple linear regression analyzes were used to evaluate the research data.

RESULTS:It was found that the mean score of the pregnant women from the Wijma delivery expectancy/experience questionnaire version A scale was 58.93±21.21 and the mean score of the Prenatal Attachment scale was 52.73±8.75. As the correlation between the mean scores of the scales was examined, it was determined that there was a significant and high correlation in the negative direction.

CONCLUSIONS:As a result, fear of childbirth was found to be moderate in the study and there is an inverse relationship between fear of childbirth and prenatal attachment. In addition, fear of childbirth is affected by sociodemographic factors and obstetric characteristics.
Pemanfaatan Aplikasi Tumblr dalam Pembelajaran Menulis Teks Anekdot Berbasis Ekologi pada Siswa Kelas 10 SMAN 1 Galis Pamekasan
Authors: Bachtiar Ricky Dwi Agus , Aflahah Aflahah
Published: January 2025

In today’s digital era, utilizing information and communication technology in the learnig process is very useful to support quality learning. One of the learning innovation that attracts attention and is relevant to anecdoce text material is the Tumblr application. This study aims to describe the application of Tumblr application and the results of applying Tumblr application in the learning process. This type of research is qualitative by using descriptive method. The data collection techniques used include observation, interviews, and documentation. In this study, the data were analyzed through three stages, namelt condensing data, presenting data, and drawing conclusions. The results of this research is that there are five steps when implementing the Tumblr application. Meanwhile, the results of applying the Tumblr application in the learning process show that students can apply the Tumblr well, combine elements of humor with themes, improve anecdotal text writing skill, realize the importance of preserving the environment, and create a collaborative learning atmosphere.
Analisis Ekolinguistik Kritis dalam Video Pandawara Group Pembersih Sampah: Perspektif Teun A. Van Dijk
Authors: Yuliastutik Rini
Published: January 2025

This research aims to analyze critical ecolinguistics in the Pandawara Group trash cleaning video from the perspective of Teun A. Van Dijk. This research was conducted using descriptive qualitative methods with content analysis methods. The data source used is the speech of Pandawara Group members in videos on the Pandawara Group Instagram. The data collection techniques used are listening techniques and note-taking techniques. Then, the data analysis technique used consists of five stages, namely watching videos on the Pandawara Group Instagram, listening to videos, identifying (determining data), classifying data (grouping), describing (depiction of data accompanied by appropriate references).  The results of this research are three data in text dimensions including, (1) Macro Structure (Thematic), (2) Superstructure (Schematic) and (3) Micro Structure (Semantic).  The three data are: (1) “Believe it or not, there are still many people in the community who throw rubbish carelessly, especially into rivers”, (2) “Hey people, don’t throw rubbish carelessly, hey! Trashbarriers are broken” and (3) “Many people use this river as a place to throw away their own waste or household rubbish.”
Persepsi Mahasiswa terhadap Perkembangan dan Penggunaan Teknologi pada Lingkungan
Authors: Susanti Aria Indah
Published: January 2025

elements in the ecology of learning itself. Therefore, the activeness of students in following technological developments should be utilized to support a more innovative and adaptive learning environment. This study was conducted to see students' perceptions of the development and use of technology, especially the impact of technology on the surrounding environment and learning environment. The approach used in this study is a quantitative approach with a descriptive research type. This research was conducted in the Faculty of Tarbiyah, State Islamic Institute of Madura. The sampling technique used was Simple Random Sampling. The data collection techniques used by the researcher were distributing questionnaires and interviews. The results of the study showed that students' perceptions of the development and use of technology in the environment showed that students understood technology and its development well and its use in the environment, especially the learning environment. Students as active users of technology (especially smartphones and the internet) have a positive perception of the development and use of technology in the learning environment.
Implementasi Kurikulum Merdeka pada Muatan Lokal Bahasa Madura di MI Kabupaten Pamekasan: Pendekatan Ekologis dalam Pendidikan Karakter dan Budaya
Authors: Alatas Mochamad Arifin , Effendy Moh. Hafid , Desiana Ananda Yogi , Nisa Hollila Hilyatun
Published: January 2025

This study aims to analyze the implementation of the Merdeka Belajar Curriculum in the local content of the Madurese language at Madrasah Ibtidaiyah (MI) in Pamekasan Regency. The research method used is descriptive qualitative, with data collection techniques including interviews, observations, and documentation studies. The results show that the application of the Merdeka Belajar Curriculum in the local content of the Madurese language faces several challenges, including a lack of resources, teacher training, and support facilities. However, there are efforts from the school to integrate cultural values and local wisdom into the learning process. This study recommends the need for improved coordination between the local government, schools, and the community to optimize curriculum implementation and provide adequate training for teachers to effectively teach the Madurese language. The findings of this research are expected to contribute to the development of regional language education in Indonesia, particularly in the context of the Merdeka Belajar Curriculum.
Ekofeminisme Spritual Starhawk: Hubungan Spiritual Alam pada Novel Mantan Ledek Tayub Karya Dandang A Dahlan
Authors: Badriya Noer Lailatul , Putikadyanto Agus Purnomo Ahmad
Published: January 2025

This research is motivated by the existence of elements of spiritual ecofeminism in the Starhawk perspective in the novel Former Ledek Tayub by Dandang A. Dahlan. The purpose of this study is to describe the form of abuse of nature carried out to oppress Ganis characters, classify the categories of spiritual ecofeminism violations experienced by Ganis characters using the Starhawk perspective, and the relationship between Ganis characters and nature.  This research is a qualitative descriptive research. With data collection techniques using reading and recording techniques. The results of the research include the form of misuse of nature carried out to oppress the character of Ganis, namely witchcraft, classifying the category of violations of spiritual ecofeminism experienced by the character Ganis in the perspective of Starhawk, namely the violation of interconnection, and the relationship of the character of Ganis with nature, namely the union of Ganis with nature with meditation in tritisan that is carried out and carrying out traditions of gratitude to the Creator of nature such as ruwatan. It can be concluded that spiritual ecofeminism from the perspective of Starhawk, spiritual ecofeminism exists as a form of self-control in utilizing the surrounding nature so that this will prevent the nature of mastery and a form of awareness that humans need to be one with nature to be close to God and create peace of heart and mind.
Analisis Pendekatan Ekologi dalam Pembelajaran Bahasa Indonesia di Era Digital
Authors: Albaburrahim Albaburrahim , Amin Moh. Badruddin
Published: January 2025

This research examines the implementation of an ecological approach in learning Indonesian in the digital era with a focus on the integration of technology and environmental awareness in the learning process. The aim of the research is to analyze Indonesian language learning through an ecological approach in the digital era. The qualitative descriptive research method uses a literature study approach. Data was collected through a literature review which included scientific journals, books, research articles and digital documents relevant to the ecological approach in Indonesian language learning and its application in the digital era. The data obtained was analyzed using content analysis techniques, which included the process of data reduction, data presentation, and drawing conclusions. The research results show, namely. First, the application of an ecological approach in learning Indonesian in the digital era can be done through various digital platforms. Second, digital technology in ecologically based Indonesian language learning offers benefits. Third, ecologically based Indonesian language learning in the digital era requires a change in method, with the teacher as a facilitator who accompanies students to explore and analyze environmental issues through digital language activities.
Educational Synousia of Protagoras and Socrates -The Birth of Ironist as Ignorant Sophist-
Authors:   Korea Soc Study Educ Princ, Eom Taedong
Published: January 2025

‘Socrates and sophists walked different paths like parallel lines that cannot meet. Socrates deserves to be praised as great sage, but sophists deserve to be blamed as corrupt professional teachers.’ This paper aims to challenge and refute this widely-accepted academic opinion about Socrates and sophists by illuminating the educational intercourse called ‘synousia’ between Protagoras and young Socrates. They held intensive educational synousia continuously whenever they meet, and passionately taught and learned about ‘What is arete?’, ‘What is the implications of the theory of man as the measure of all things?’, and ‘How can education transform a man to be more advanced measure?’ Through these educational synousia, Protagoras established the way of true sophist, and Socrates became an ignorant sophist as ironist who carried out unprecedented educational activities with his famous midwifery. This paper can be considered to be an interim report of long term research project trying to redescribe the reciprocal relation of Protagoras and Socrates. Although far from satisfactory, this paper argues that the original form of sophist, Protagoras’ influence on Socrates, and the entanglement of living, knowing and education of Protagoras and Socrates must be rediscussed from new perspective.
Teatro e adolescência
Authors: Gasperin Luiz Eduardo Rodrigues
Published: January 2025

O texto apresenta uma reflexão gerada no chão da sala de aula de Ensino Fundamental – anos finais – de uma escola pública estadual do interior de Minas Gerais. A discussão tem como ponto de partida, o teatro; a Educação Básica; o adolescer. Ao longo da escrita esses pontos são interseccionados com o objetivo de questionar a noção de ensino tradicional e seus conceitos generalizantes, pautados nas colonialidades.
Perilaku Konsumtif Penggemar AKB48: Studi Kasus Mahasiswa Bahasa dan Sastra Jepang Universitas Airlangga
Authors: Nur Kumala Hapsari Meilani , Syafik Abdurrahman , Isya Putra Maulana , Ikbal Maulana , Rachmasari Firtha Ayu
Published: January 2025

Penggemar idol Jepang di Indonesia dapat dikatakan cukup banyak terutama untuk kalangan remaja dewasa dengan rentang usia 18-29 tahun. Penelitian ini menganalisis bagaimana perilaku konsumtif penggemar grup idola AKB48 dengan studi kasus mahasiswa Bahasa dan Sastra Jepang Universitas Airlangga. Mahasiswa Bahasa dan Sastra Jepang relevan untuk diteliti karena usia mereka rata-rata antara 18-29 tahun. Peneliti mengasumsikan bahwa mahasiswa Bahasa dan Sastra Jepang dapat mewakili sekelompok remaja dewasa awal yang memiliki ketertarikan atas budaya populer Jepang. Penelitian ini adalah penelitian kualitatif dengan pendekatan studi kasus. Penentuan informan sendiri menggunakan teknik snowball sampling dan didapatkan empat informan. Teknik Pengumpulan data dalam penelitian ini menggunakan teknik wawancara mendalam. Data yang ditemukan, dianalisis melalui teori konsumerisme Jean Baudrillard. Hasil penelitian menunjukkan bahwa ada perilaku konsumtif yang dilakukan oleh keempat mahasiswa Bahasa dan Sastra Jepang penggemar AKB48. Perilaku konsumtif yang tampak meliputi membeli produk-produk yang dipromosikan oleh anggota AKB48, mengoleksi barang-barang dan pernak-pernik dari AKB48, mengoleksi DVD/CD, menonton konser yang diadakan baik secara online maupun offline, mengikuti acara temu penggemar, mengadakan perayaan ulang tahun untuk member AKB48 dan lain-lain.