bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting NF-κB Signaling in Cancer Stem Cells: A Narrative Review
Authors: Kaltschmidt Barbara , Witte Kaya E. , Greiner Johannes F. W. , Weissinger Florian , Kaltschmidt Christian
Published: January 2022

Among the cell populations existing within a tumor, cancer stem cells are responsible for metastasis formation and chemotherapeutic resistance. In the present review, we focus on the transcription factor NF-κB, which is present in every cell type including cancer stem cells. NF-κB is involved in pro-tumor inflammation by its target gene interleukin 1 (IL1) and can be activated by a feed-forward loop in an IL1-dependent manner. Here, we summarize current strategies targeting NF-κB by chemicals and biologicals within an integrated cancer therapy. Specifically, we start with a tyrosine kinase inhibitor targeting epidermal growth factor (EGF)-receptor-mediated phosphorylation. Furthermore, we summarize current strategies of multiple myeloma treatment involving lenalidomide, bortezomib, and dexamethasone as potential NF-κB inhibitors. Finally, we discuss programmed death-ligand 1 (PD-L1) as an NF-κB target gene and its role in checkpoint therapy. We conclude, that NF-κB inhibition by specific inhibitors of IκB kinase was of no clinical use but inhibition of upstream and downstream targets with drugs or biologicals might be a fruitful way to treat cancer stem cells.
Circulating LIGHT (TNFSF14) and Interleukin-18 Levels in Sepsis-Induced Multi-Organ Injuries
Authors: Qu Hui-Qi , Snyder James , Connolly John , Glessner Joseph , Kao Charlly , Sleiman Patrick , Hakonarson Hakon
Published: January 2022

The novel therapeutic target cytokine LIGHT (TNFSF14) was recently shown to play a major role in COVID-19-induced acute respiratory distress syndrome (ARDS). This study aims to investigate the associations of plasma LIGHT and another potentially targetable cytokine, interleukin-18 (IL-18), with ARDS, acute hypoxic respiratory failure (AHRF), or acute kidney injury (AKI), caused by non-COVID-19 viral or bacterial sepsis. A total of 280 subjects diagnosed with sepsis, including 91 cases with sepsis triggered by viral infections, were investigated in this cohort study. Day 0 plasma LIGHT and IL-18, as well as 59 other biomarkers (cytokines, chemokines, and acute-phase reactants) were measured by sensitive bead immunoassay and associated with symptom severity. We observed significantly increased LIGHT level in both bacterial sepsis patients (p = 1.80 × 10−5) and patients with sepsis from viral infections (p = 1.78 × 10−3). In bacterial sepsis, increased LIGHT level was associated with ARDS, AKI, and higher Apache III scores, findings also supported by correlations of LIGHT with other biomarkers of organ failure. IL-18 levels were highly variable across individuals and consistently correlated with Apache III scores, mortality, and AKI in both bacterial and viral sepsis. There was no correlation between LIGHT and IL-18. For the first time, we demonstrate independent effects of LIGHT and IL-18 in septic organ failure. The association of plasma LIGHT with AHRF suggests that targeting the pathway warrants exploration, and ongoing trials may soon elucidate whether this is beneficial. Given the large variance of plasma IL-18 among septic subjects, targeting this pathway requires precise application.
Decellularized In Vitro Capillaries for Studies of Metastatic Tendency and Selection of Treatment
Authors: Huttala Outi , Loreth Desiree , Staff Synnöve , Tanner Minna , Wikman Harriet , Ylikomi Timo
Published: January 2022

Vascularization plays an important role in the microenvironment of the tumor. Therefore, it should be a key element to be considered in the development of in vitro cancer assays. In this study, we decellularized in vitro capillaries to remove genetic material and optimized the medium used to increase the robustness and versatility of applications. The growth pattern and drug responses of cancer cell lines and patient-derived primary cells were studied on decellularized capillaries. Interestingly, two distinct growth patterns were seen when cancer cells were grown on decellularized capillaries: “network” and “cluster”. Network formation correlated with the metastatic properties of the cells and cluster formation was observed in non-metastatic cells. Drug responses of patient-derived cells correlated better with clinical findings when cells were cultured on decellularized capillaries compared with those cultured on plastic. Decellularized capillaries provide a novel method for cancer cell culture applications. It bridges the gap between complex 3D culture methods and traditional 2D culture methods by providing the ease and robustness of 2D culture as well as an in vivo-like microenvironment and scaffolding for 3D cultures.
Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates
Authors: Prikhodko Veronika A. , Bezborodkina Natalia N. , Okovityi Sergey V.
Published: January 2022

Non-alcoholic fatty liver disease (NAFLD), or metabolic (dysfunction)-associated fatty liver disease (MAFLD), is characterized by high global incidence and prevalence, a tight association with common metabolic comorbidities, and a substantial risk of progression and associated mortality. Despite the increasingly high medical and socioeconomic burden of NAFLD, the lack of approved pharmacotherapy regimens remains an unsolved issue. In this paper, we aimed to provide an update on the rapidly changing therapeutic landscape and highlight the major novel approaches to the treatment of this disease. In addition to describing the biomolecules and pathways identified as upcoming pharmacological targets for NAFLD, we reviewed the current status of drug discovery and development pipeline with a special focus on recent evidence from clinical trials.
Identification of Targetable Liabilities in the Dynamic Metabolic Profile of EGFR-Mutant Lung Adenocarcinoma: Thinking beyond Genomics for Overcoming EGFR TKI Resistance
Authors: Gkountakos Anastasios , Centonze Giovanni , Vita Emanuele , Belluomini Lorenzo , Milella Michele , Bria Emilio , Milione Massimo , Scarpa Aldo , Simbolo Michele
Published: January 2022

The use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) as first-line treatment in patients with lung adenocarcinoma (LUAD) harboring EGFR-activating mutations has resulted in a dramatic improvement in the management of the disease. However, the long-term clinical benefit is inevitably compromised by multiple resistance mechanisms. Accumulating evidence suggests that metabolic landscape remodeling is one of the mechanisms that EGFR-mutant LUAD cells activate, thus acquiring higher plasticity, tolerating EGFR TKI-mediated cytotoxic stress, and sustaining their oncogenic phenotype. Several metabolic pathways are upregulated in EGFR TKI-resistant models modulating the levels of numerous metabolites such as lipids, carbohydrates, and metabolic enzymes which have been suggested as potential mediators of resistance to EGFR TKIs. Moreover, metabolites have been shown to carry signals and stimulate oncogenic pathways and tumor microenvironment (TME) components such as fibroblasts, facilitating resistance to EGFR TKIs in various ways. Interestingly, metabolic signatures could function as predictive biomarkers of EGFR TKI efficacy, accurately classifying patients with EGFR-mutant LUAD. In this review, we present the identified metabolic rewiring mechanisms and how these act either independently or in concert with epigenetic or TME elements to orchestrate EGFR TKI resistance. Moreover, we discuss potential nutrient dependencies that emerge, highlighting them as candidate druggable metabolic vulnerabilities with already approved drugs which, in combination with EGFR TKIs, might counteract the solid challenge of resistance, hopefully prolonging the clinical benefit.
A Novel Multi-Mode Thermal Therapy for Colorectal Cancer Liver Metastasis: A Pilot Study
Authors: Li Wentao , Lou Yue , Wang Guangzhi , Zhang Kangwei , Xu Lichao , Liu Ping , Xu Lisa X.
Published: January 2022

A novel multi-mode thermal therapy was developed for local tumor ablation and the systemic stimulation of anti-tumor immunity, consisting of a rapid liquid nitrogen freezing, and followed by the radiofrequency heating of target tumor tissue. This pilot study aimed to compare the therapeutic effects of the new therapy with conventional radiofrequency ablation (RFA) on patients with colorectal cancer liver metastasis (CRCLM). From August 2016 to September 2019, thirty-one patients with CRCLM received either multi-mode thermal therapy (n = 17) or RFA (n = 14). Triphasic contrast-enhanced magnetic resonance imaging (MRI), routine blood tests, and peripheral blood immune responses were evaluated before the treatment and in 1, 3, 6, and 12 months after. Local tumor response and progression-free survival (PFS) were assessed using the Kaplan-Meier method, and pre- and post-treatment immune cell counts were analyzed using Mann-Whitney U and Wilcoxon tests. A significantly longer PFS was observed in the multi-mode thermal therapy group in comparison to that of the conventional RFA group (median, 11.4 versus 3.4 months, p = 0.022). It was found that multi-mode therapy induced the functional maturation of dendritic cells, promoted CD4+ T cell-mediated antitumor responses, and decreased regulatory T cells, contributing to better therapeutic efficacy in CRCLM patients.
Genes Involved in Immune Reinduction May Constitute Biomarkers of Response for Metastatic Melanoma Patients Treated with Targeted Therapy
Authors: Berciano-Guerrero Miguel-Angel , Lavado-Valenzuela Rocío , Moya Aurelio , delaCruz-Merino Luis , Toscano Fátima , Valdivia Javier , Castellón Victoria , Henao-Carrasco Fernando , Sancho Pilar , Onieva-Zafra Juan-Luis , Navas-Delgado Ismael , Rueda-Dominguez Antonio , Perez-Ruiz Elisabeth , Alba Emilio
Published: January 2022

Targeted therapy in metastatic melanoma often achieves a major tumour regression response and significant long-term survival via the release of antigens that reinduce immunocompetence. The biomarkers thus activated may guide the prediction of response, but this association and its mechanism have yet to be established. Blood samples were collected from nineteen consecutive patients with metastatic melanoma before, during, and after treatment with targeted therapy. Differential gene expression analysis was performed, which identified the genes involved in the treatment, both in the first evaluation of response and during progression. Although clinical characteristics of the patients were poorer than those obtained in pivotal studies, radiological responses were similar to those reported previously (objective response rate: 73.7%). In the first tumour assessment, the expression of some genes increased (CXCL-10, SERPING1, PDL1, and PDL2), while that of others decreased (ARG1, IL18R1, IL18RAP, IL1R1, ILR2, FLT3, SLC11A1, CD163, and S100A12). The analysis of gene expression in blood shows that some are activated and others inhibited by targeted therapy. This response pattern may provide biomarkers of the immune reinduction response, which could be used to study potential combination treatments. Nevertheless, further studies are needed to validate these results.
Modeling Alzheimer’s Disease in Caenorhabditis elegans
Authors: Alvarez Javier , Alvarez-Illera Pilar , Santo-Domingo Jaime , Fonteriz Rosalba I. , Montero Mayte
Published: January 2022

Alzheimer’s disease (AD) is the most frequent cause of dementia. After decades of research, we know the importance of the accumulation of protein aggregates such as β-amyloid peptide and phosphorylated tau. We also know that mutations in certain proteins generate early-onset Alzheimer’s disease (EOAD), and many other genes modulate the disease in its sporadic form. However, the precise molecular mechanisms underlying AD pathology are still unclear. Because of ethical limitations, we need to use animal models to investigate these processes. The nematode Caenorhabditis elegans has received considerable attention in the last 25 years, since the first AD models overexpressing Aβ peptide were described. We review here the main results obtained using this model to study AD. We include works studying the basic molecular mechanisms of the disease, as well as those searching for new therapeutic targets. Although this model also has important limitations, the ability of this nematode to generate knock-out or overexpression models of any gene, single or combined, and to carry out toxicity, recovery or survival studies in short timeframes with many individuals and at low cost is difficult to overcome. We can predict that its use as a model for various diseases will certainly continue to increase.
Acknowledgment to Reviewers of Biomimetics in 2021
Authors:   Biomimetics Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
A Self-Powered Wearable Motion Sensor for Monitoring Volleyball Skill and Building Big Sports Data
Authors: Liu Weijie , Long Zhihe , Yang Guangyou , Xing Lili
Published: January 2022

A novel self-powered wearable motion sensor for monitoring the spiking gesture of volleyball athletes has been manufactured from piezoelectric PVDF film. The PVDF film can convert body mechanical energy into electricity through the piezoelectric effect, and the flexible device can be conformably attached on the hand or arm. The sensor can work independently without power supply and actively output piezoelectric signals as the sports information. The sensor can detect the tiny and fine motion of spiking movement in playing volleyball, reflecting the skill. Additionally, the sensor can also real-time monitor the pulse changes and language during a volleyball match. The self-powered sensors can link to a wireless transmitter for uploading the sports information and building big sports data. This work can provoke a new direction for real-time sports monitoring and promote the development of big sports data.
Strategies for Improving Small-Molecule Biosensors in Bacteria
Authors: Miller Corwin A. , Ho Joanne M. L. , Bennett Matthew R.
Published: January 2022

In recent years, small-molecule biosensors have become increasingly important in synthetic biology and biochemistry, with numerous new applications continuing to be developed throughout the field. For many biosensors, however, their utility is hindered by poor functionality. Here, we review the known types of mechanisms of biosensors within bacterial cells, and the types of approaches for optimizing different biosensor functional parameters. Discussed approaches for improving biosensor functionality include methods of directly engineering biosensor genes, considerations for choosing genetic reporters, approaches for tuning gene expression, and strategies for incorporating additional genetic modules.
An Enzymatic Biosensor for the Detection of D-2-Hydroxyglutaric Acid in Serum and Urine
Authors: Wu Bo , Li Zehua , Kang Zepeng , Ma Chunling , Song Haiyan , Lu Fuping , Zhu Zhiguang
Published: January 2022

D-2-hydroxyglutaric acid (D2HG) is overproduced as a result of the D-2-hydroxyglutaric aciduria and relevant cancers, caused by gene mutation. Accurate analysis of D2HG could help rapid diagnosis of these diseases and allow for timely treatment. In this work, a D-2-hydroxyglutarate dehydrogenase from Ralstonia solanacearum (RsD2HGDH) is cloned and recombinantly expressed. This enzyme features the direct electron transfer to chemical electron mediators (such as methylene blue (MB)) in the absence of additional coenzymes. Therefore, NAD+, a natural electron acceptor for the commercial D2HGDH and usually known for being unstable and difficult for immobilization can be avoided in the preparation of biosensors. The RsD2HGDH and MB are co-immobilized on a two-dimensional material, Ti3C2 MXene, followed by drop-coating on the gold screen-printed electrode (AuSPE) to construct a compact and portable biosensor. The D2HG in samples can be catalyzed by RsD2HGDH, where the current change is measured by chronoamperometry at −0.23 V. The biosensor shows a D2HG detection range of 0.5 to 120 µM (R2 = 0.9974) with a sensitivity of 22.26 μA mM−1 cm−2 and a detection limit of 0.1 µM (S/N = 3). The biosensor retains 72.52% performance of its incipient state after 30 days of storage. The samples of D2HG-containing fetal bovine serum and artificial urine were analyzed with the recovery of 99.56% to 106.83% and 97.30% to 102.47% further indicating the great application potential of our portable D2HG biosensor.
High-Level Executive Functions: A Possible Role of Sex and Weight Condition in Planning and Decision-Making Performances
Authors: Favieri Francesca , Forte Giuseppe , Pazzaglia Mariella , Chen Eunice Y. , Casagrande Maria
Published: January 2022

Evidence indicates an association between executive functioning and increased weight, with different patterns ascribed to individual differences (sex, age, lifestyles). This study reports on the relationship between high-level executive functions and body weight. Sixty-five young adults participated in the study: 29 participants (14 males, 15 females) in the normal weight range; 36 participants (18 males, 18 females) in the overweight range. The Iowa Gambling Task (IGT) and Tower of London Task were administered to assess decision making and planning. Planning did not differ in individuals in the normal-weight and overweight groups, and no difference emerged between females and males. However, normal and overweight males and females had different patterns in decision making. On the long-term consequences index of the IGT, females reported lower scores than males. Males in the overweight range had a lower long-term consequences index on the IGT than normal-weight males, while this pattern did not emerge in females. These findings suggest that decision-making responses may differ in the overweight relative to healthy weight condition, with a different expression in males and females. This pattern should be considered in weight loss prevention strategies, possibly adopting different approaches in males and females.
Heart Rate Variability and Pain: A Systematic Review
Authors: Forte Giuseppe , Troisi Giovanna , Pazzaglia Mariella , Pascalis Vilfredo De , Casagrande Maria
Published: January 2022

Background and Objective: Heart rate variability (HRV) as an index of the autonomic nervous system appears to be related to reactivity to experimental pain stimuli. HRV could better explain the contributions of sympathetic and parasympathetic activity response to nociceptive stimulation. The aim of this study was to systematically review and synthesize the current evidence on HRV in relation to the experience of pain in experimental tasks. Databases and Data Treatment: Studies indexed in the PubMed, PsycINFO, MEDLINE, WebOfScience, and Scopus databases were reviewed for eligibility. Studies on the autonomic response (i.e., HRV) to experimentally induced pain in healthy adults were included. Different methods of pain induction were considered (e.g., thermal, pressure, and electrical). Data were synthesized considering the association between HRV and both pain induction and subjective measures of pain. Results: Seventy-one studies were included. The results underline significant change in both the sympathetic and parasympathetic autonomic nervous systems during the painful stimulation independent of the pain induction method. The autonomic reaction to pain could be affected by several factors, such as sex, age, body mass index, breathing patterns, the intensity of the stimulation, and the affective state. Moreover, an association between the autonomic nervous system and the subjective experience of pain was found. Higher parasympathetic activity was associated with better self-regulation capacities and, accordingly, a higher pain inhibition capacity. Conclusions: HRV appears to be a helpful marker to evaluate nociceptive response in experimentally induced pain. Future studies are also needed in clinical samples to understand better the interindividual changes of autonomic response due to pain stimuli.
Olfactory Dysfunction, Headache, and Mental Clouding in Adults with Long-COVID-19: What Is the Link between Cognition and Olfaction? A Cross-Sectional Study
Authors: Di Stadio Arianna , Brenner Michael J. , De Luca Pietro , Albanese Maria , D’Ascanio Luca , Ralli Massimo , Roccamatisi Dalila , Cingolani Cristina , Vitelli Federica , Camaioni Angelo , Di Girolamo Stefano , Bernitsas Evanthia
Published: January 2022

Smell alteration and cognitive impairment are common features of the Long-COVID Syndrome. Mental clouding, often described as brain fog, might affect smell by altering recollection of odors or through a share mechanism of neuroinflammation. We investigated mental clouding, headache, and cognitive function in adult patients with persistent COVID-19 olfactory dysfunction. This multi-center cross-sectional study enrolled 152 adults with self-reported olfactory dysfunction from 3 tertiary centers specialized in COVID-19 olfactory disorders. Inclusion criteria were smell alterations after COVID-19 persisting over 6 months from infection, age >18 and < 65. Exclusion criteria included smell alterations, headache, or memory problems prior to COVID-19 infection. The patients were evaluated by olfactometry, nasal endoscopy, headache scale, cognitive assessment, Mini Mental State Examination (MMSE), and self-reported measures. Smell dysfunction was stratified and classified based on olfactory deficit severity and presence of olfactory distortion (parosmia, cacosmia). Data on smell disorder, mental clouding, MMSE, and headache were analyzed to assess correlations. Among the 152 patients studied, 50 (32.8%) presented with anosmia, 25 (16.4%) with hyposmia, 10 (6.6%) with parosmia/cacosmia, and 58 patients (38.2%) with a combination of hyposmia and parosmia; seven (4.6%) patients suffered from headache exclusively, and two (1.4%) had headache and mental clouding as their primary symptom. Headache was reported by 76 (50%) patients, and mental clouding by 71 (46.7%). The patients reporting headache, mental clouding, or both, had significantly increased risk of suffering from anosmia and/or hyposmia when compared with their counterparts without these neurological symptoms. No patients had reduced MMSE scores. In our cohort of adult patients with post-COVID-19, smell alterations persisting over 6 months, cognitive impairment and headache were associated with more severe olfactory loss, consistent with neuroinflammatory mechanisms mediating a variety of Long-COVID symptoms.
Focusing in on the Future of Focused Ultrasound as a Translational Tool
Authors: Spivak Norman M. , Sanguinetti Joseph L. , Monti Martin M.
Published: January 2022

This article summarizes the field of focused ultrasound for use in neuromodulation and discusses different ways of targeting, delivering, and validating focused ultrasound. A discussion is focused on parameter space and different ongoing theories of ultrasonic neuromodulation. Current and future applications of the technique are discussed.
Sexual Dysfunctions in Parkinson’s Disease and Their Influence on Partnership—Data of the PRISM Study
Authors: Kinateder Thomas , Marinho Daniela , Gruber Doreen , Hatzler Laura , Ebersbach Georg , Gandor Florin
Published: January 2022

Background: Sexual dysfunctions (SD) are common but underreported in Parkinson’s disease (PD) and have negative impacts on the quality of life (QoL) and partnership. Methods: We analyzed the data set from the PRISM study for demographics of SD and their influence on quality of life and partnership. Results: 449/861 (52.1%) PD patients reported SD, with male patients being affected more often and having a longer course of disease. The most common SD in men was erectile dysfunction (ED) (n = 152), while women’s most frequent complaints were orgasm dysfunction (n = 84) and reduced libido (n = 81). Hypersexual SDs were reported significantly more often by men. Spousal caregivers of patients reporting inability to relax and enjoy sex and reduced libido indicated a negative influence on the relationship in general. Negative effects on the sexual relationship were reported significantly more often for patients with ED, difficulties with sexual arousal, inability to relax and enjoy sex, and reduced libido. Hypersexual dysfunctions showed no effect on the relationship. Conclusion: SD is a common but underreported problem in the treatment of patients with PD. Due to the negative influence on the relationship and QoL of patients and caregivers, SD should be assessed routinely.
Lipoxin A4 Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage
Authors: Futokoro Risa , Hijioka Masanori , Arata Moe , Kitamura Yoshihisa
Published: January 2022

Intracerebral hemorrhage (ICH) is caused by the rupture of blood vessels in the brain. The excessive activation of glial cells and the infiltration of numerous inflammatory cells are observed during bleeding. Thrombin is a key molecule that triggers neuroinflammation in the ICH brain. In this study, we focused on lipoxin A4 (LXA4), an arachidonic acid metabolite that has been reported to suppress inflammation and cell migration. LXA4 and BML-111, an agonist of the LXA4 receptor/formyl peptide receptor 2 (ALX/FPR2), suppressed microglial activation; LXA4 strongly inhibited the migration of neutrophil-like cells in vitro. ALX/FPR2 was expressed on neutrophils in the ICH mouse brain and the daily administration of BML-111 attenuated the motor coordination dysfunction and suppressed the production of proinflammatory cytokines in the ICH mouse brain. On the other hand, BML-111 did not show a significant reduction in the number of microglia and neutrophils. These results suggest that systemic administration of ALX/FPR2 agonists may suppress the neuroinflammatory response of microglia and neutrophils without a change in cell numbers. Additionally, their combination with molecules that reduce cell numbers, such as modulators of leukotriene B4 signaling, may be required in future studies.
Motor Coordination and Grip Strength of the Dominant and Non-Dominant Affected Upper Limb Depending on the Body Position—An Observational Study of Patients after Ischemic Stroke
Authors: Olczak Anna , Truszczyńska-Baszak Aleksandra
Published: January 2022

Stroke is one of the leading causes of human disability globally. Motor function deficits resulting from a stroke affect the entire body, but relatively often it is the upper limbs that remain ineffective, which is very limiting in everyday life activities. The finding in neurorehabilitation that trunk control contributes to upper limb function is relatively common but has not been confirmed in clinical trials. This observational prospective study aims to analyze the effect of the position of the trunk and the affected upper limb on the coordination and grip strength of the affected dominant and non-dominant hand and wrist in people after ischemic stroke. The research was carried out at the Department of Neurological Rehabilitation, on a group of 60 patients with acute ischemic stroke. A Hand Tutor device and a hand dynamometer were used for the main measurements of the motor coordination parameters (maximum range of motion, frequency of movement) and the grip strength of the dominant and non-dominant upper limb. The patients were examined in two positions: sitting without back support and lying on the back with stabilization of the upper limb. Higher and relevant results were observed in the non-dominant hand, in the supine position in terms of motor coordination parameters of the fingers (p = 0.019; p = 0.011) and wrist (p = 0.033), and grip strength (p = 0.017). Conclusions: The laying position and stabilization of the affected upper limb in the acute phase following ischemic stroke is more beneficial for the coordination of movements and grip strength of the non-dominant hand.
Social Undermining and Employee Creativity: The Mediating Role of Interpersonal Distrust and Knowledge Hiding
Authors: Khan Muhammad Arsalan , Malik Omer Farooq , Shahzad Asif
Published: January 2022

This study aims to examine how social undermining restrains employee creativity. Specifically, an attempt is made to investigate the serial mediating role of interpersonal distrust and knowledge hiding in the relationship between social undermining and employee creativity. This study used purposive sampling to draw 309 employees from the advertising agencies of Pakistan. We used a time-lagged research design to collect the data on the measures at three different points in time. A self-administered questionnaire was used for the collection of data. We followed variance-based structural equation modeling (SEM) to conduct the data analysis in SmartPLS. Our study results indicated a significant negative association between social undermining and employee creativity, while serial mediation analysis showed that interpersonal distrust and knowledge hiding partially mediated the above linkage. This study’s findings contribute to the literature on employee creativity by identifying and testing social undermining as an interpersonal inhibitor factor that impairs employee creativity, and this relationship is serially mediated by interpersonal distrust and knowledge hiding. This study offers valuable insights for the managers of advertising agencies.
Resiliency with Forced Migrants: A Qualitative Study of Providers and Forced Migrants through a Resilience Perspective
Authors: Dubus Nicole
Published: January 2022

In the last ten years, the world has experienced unprecedented, forced migration due to civil unrest, political persecution, and the ever-growing climate crisis. This is a qualitative study of the professional experiences of social workers (n = 73) working with forced migrants (n = 34) and the lived experiences of forced migrants in several countries: Germany, Greece, Iceland, Mexico, Switzerland, and the United States. Social workers reported that most of their interventions involved short-term case management that focused on securing initial housing and healthcare. Cognitive Behavioral Therapy (CBT) was the primary intervention for behavioral health issues. The recipients of these services were appreciative of the pragmatic approach of case management as it helped them meet concrete needs. When resiliency enhancing interventions were used, recipients reported a greater sense of self-control, greater optimism for the future, and less anxious symptoms. The resiliency model used is discussed. This is a possible universal approach to working with forced migrants.
Finite Element Modelling to Predict the Fire Performance of Bio-Inspired 3D-Printed Concrete Wall Panels Exposed to Realistic Fire
Authors: Suntharalingam Thadshajini , Upasiri Irindu , Nagaratnam Brabha , Poologanathan Keerthan , Gatheeshgar Perampalam , Tsavdaridis Konstantinos Daniel , Nuwanthika Dilini
Published: January 2022

Large-scale additive manufacturing (AM), also known as 3D concrete printing, is becoming well-recognized and, therefore, has gained intensive research attention. However, this technology requires appropriate specifications and standard guidelines. Furthermore, the performance of printable concrete in elevated temperature circumstances has not yet been explored extensively. Hence, the authors believe that there is a demand for a set of standardized findings obtained with the support of experiments and numerical modelling of the fire performance of 3D-printed concrete structural elements. In general, fire experiments and simulations focus on ISO 834 standard fire. However, this may not simulate the real fire behaviour of 3D-printed concrete walls. With the aim of bridging this knowledge disparity, this article presents an analysis of the fire performance of 3D-printed concrete walls with biomimetic hollow cross sections exposed to realistic individual fire circumstances. The fire performance of the non-load-bearing 3D-printed concrete wall was identified by developing a suitable numerical heat transfer model. The legitimacy of the developed numerical model was proved by comparing the time–temperature changes with existing results derived from fire experiments on 3D-printed concrete walls. A parametric study of 96 numerical models was consequently performed and included different 3D-printed concrete wall configurations under four fire curves (standard, prolonged, rapid, and hydrocarbon fire). Moreover, 3D-printed concrete walls and mineral wool cavity infilled wall panels showed enhanced fire performance. Moreover, the cellular structures demonstrated superior insulation fire ratings compared to the other configurations.
Drivers for Digital Twin Adoption in the Construction Industry: A Systematic Literature Review
Authors: Opoku De-Graft Joe , Perera Srinath , Osei-Kyei Robert , Rashidi Maria , Famakinwa Tosin , Bamdad Keivan
Published: January 2022

Digital twin (DT) is gaining increasing attention due to its ability to present digital replicas of existing assets, processes and systems. DT can integrate artificial intelligence, machine learning, and data analytics to create real-time simulation models. These models learn and update from multiple data sources to predict their physical counterparts’ current and future conditions. This has promoted its relevance in various industries, including the construction industry (CI). However, recognising the existence of a distinct set of factors driving its adoption has not been established. Therefore, this study aims to identify the drivers and integrate them into a classification framework to enhance its understanding. Utilising popular databases, including Scopus, Web of Science, and ScienceDirect, a systematic literature review of 58 relevant DT adoptions in the CI research was conducted. From the review, the drivers for DT adoption in the CI were identified and classified. The results show that developed countries such as the UK, US, Australia, and Italy have been the top countries in advancing DT adoption in the CI, while developing countries have made commendable contributions. A conceptual framework has been developed to enhance the successful adoption of DT in the CI based on 50 identified drivers. The major categories of the framework include concept-oriented drivers, production-driven drivers, operational success drivers, and preservation-driven drivers. The developed framework serves as a guide to propel DT adoption in the CI. Furthermore, this study contributes to the body of knowledge about DT adoption drivers, which is essential for DT promotion in the CI.
Numerical Investigation on Blast Response of Cold-Formed Steel Framing Protected with Functionally Graded Composite Material
Authors: Ali Elias , Althoey Fadi
Published: January 2022

This paper presents a numerical simulation on the blast response of cold-formed steel (CFS) structural framing system protected with a functionally graded composite material (FGM) panel. The steel frame consists of four CFS studs, which were protected by 12.5 mm thick gypsum, aluminum composite, and FGM composite materials on both sides. The numerical simulation was performed using ABAQUS on a 1.8 m × 2.4 m, overall wall panel exposed to air blast on one side. A 1.0 kg TNT explosive charge placed at four standoff distances (R) of 1.0 m, 1.5 m, 2.0 m, and 2.5 m from the framing were investigated. The FGM board was modeled using a stepwise material variation using the power-law material function. Deformation and failure modes of the studs, as well as the protective materials, were compared to the same framing system but with different protective materials, including conventional gypsum boards and aluminum composite panels. Based on the observation from the analysis and computational simulation, the proposed protective composite material (FGM) resulted in a smaller deformation at peak overpressure at a given standoff distance (R) and local failure modes on studs. The same frame system with gypsum and aluminum panel exhibited excessive deformation as well as an early collapse of the CFS studs. This observation can lead to an alternative material solution in blast-resistant design.
Off-Site Construction Three-Echelon Supply Chain Management with Stochastic Constraints: A Modelling Approach
Authors: Salari Samira Al-Sadat , Mahmoudi Hediye , Aghsami Amir , Jolai Fariborz , Jolai Soroush , Yazdani Maziar
Published: January 2022

Off-site construction is becoming more popular as more companies recognise the benefits of shifting the construction process away from the construction site and into a controlled manufacturing environment. However, challenges associated with the component supply chain have not been fully addressed. As a result, this study proposes a model for three-echelon supply chain supply management in off-site construction with stochastic constraints. In this paper, multiple off-site factories produce various types of components and ship them to supplier warehouses to meet the needs of the construction sites. Each construction site is directly served by a supplier warehouse. The service level for each supplier warehouse is assumed to be different based on regional conditions. Because of the unpredictable nature of construction projects, demand at each construction site is stochastic, so each supplier warehouse should stock a certain number of components. The inventory control policy is reviewed regularly and is in (R, s, S) form. Two objectives are considered: minimising total cost while achieving the desired delivery time for construction sites due to their demands and balancing driver workloads during the routeing stage. A grasshopper optimisation algorithm (GOA) and an exact method are used to solve this NP-hard problem. The findings of this study contribute new theoretical and practical insights to a growing body of knowledge about supply chain management strategies in off-site construction and have implications for project planners and suppliers, policymakers, and managers, particularly in companies where an unplanned supply chain exacerbates project delays and overrun costs.
A Multifunctional Solution for Simultaneous Sound Insulation and Acoustic Conditioning—An Example of Application in a Radio Studio
Authors: Rodríguez Juan C. , Alba Jesús , del Rey Romina
Published: January 2022

In building acoustics, two different problems usually arise. There is a need to comply with established sound insulation parameters, but there are also legislative conditions concerning reverberation time. It is therefore necessary to acoustically insulate and condition the enclosures. When designing the acoustic treatment of buildings, sound insulation is always considered before acoustic conditioning. There are multiple solutions for sound insulation; one of them consists of a base wall reinforced with a plasterboard lining. The sound insulation improvement provided by these solutions will depend on the type of base wall used. A common solution for acoustic conditioning is the use of perforated plate lining systems with a plenum filled with sound absorbing material. This work presents a solution for simultaneous sound insulation and conditioning improvement, reducing the installation costs. Materials that provide the acoustic conditioning features were analyzed to validate their use in the complete solution, performing airflow resistance tests. The complete solution was also evaluated on a laboratory scale by conducting tests in a reverberation chamber and in a transmission chamber for small samples. Finally, the effectiveness of the presented solution was assessed with in-situ tests in a radio studio.
Improvement of the Inspection Interval of Highway Bridges through Predictive Models of Deterioration
Authors: Santos Ademir F. , Bonatte Maurício S. , Sousa Hélder S. , Bittencourt Túlio N. , Matos José C.
Published: January 2022

Bridges have substantial significance within the transport system, considering that their functionality is essential for countries’ social and economic development. Accordingly, a superior level of safety and serviceability must be reached to ensure the operating status of the bridge network. On that account, the recent collapses of road bridges have led the technical–scientific community and society to reflect on the effectiveness of their management. Bridges in a network are likely to share coinciding environmental conditions but may be subjected to distinct structural deterioration processes over time depending on their age, location, structural type, and other aspects. This variation is usually not considered in the bridge management predictions. For instance, the Brazilian standards consider a constant inspection periodicity, regardless of the bridges’ singularities. Consequently, it is helpful to pinpoint and split the bridge network into classes sharing equivalent deterioration trends to obtain a more precise prediction and improve the frequency of inspections. This work presents a representative database of the Brazilian bridge network, including the most relevant data obtained from inspections. The database was used to calibrate two independent predictive models (Markov and artificial neural network). The calibrated model was employed to simulate different scenarios, resulting in significant insights to improve the inspection periodicity. As a result, the bridge’s location accounting for the differentiation of exposure was a critical point when analyzing the bridge deterioration process. Finally, the degradation models developed following the proposed procedure deliver a more reliable forecast when compared to a single degradation model without parameter analysis. These more reliable models may assist the decision process of the bridge management system (BMS).
Method to Identify the Likelihood of Death in Residential Buildings during Coastal Flooding
Authors: Creach Axel , Bastidas-Arteaga Emilio , Pardo Sophie , Mercier Denis
Published: January 2022

Tools exist to predict fatalities related to floods, but current models do not focus on fatalities in buildings. For example, Storm Xynthia in France in 2010 resulted in 41 drowning deaths inside buildings. Therefore, there has been increasing recognition of the risk of people becoming trapped in buildings during floods. To identify buildings which could expose their occupants to a risk of death in the case of flooding, we propose the use of the extreme vulnerability index (VIE index), which identifies which buildings are at greatest risk of trapping people during floods. In addition, the “mortality function method” is used to further estimate the expected number of fatalities based on (1) groups of vulnerable people (e.g., aged or disabled), (2) the location of buildings in relation to major watercourses, and (3) the configuration of buildings (e.g., single or multiple entries and single or multiple stories). The overall framework is derived from case studies from Storm Xynthia which give a deterministic approach for deaths inside buildings for coastal floods, which is suited for low-lying areas protected by walls or sandy barriers. This methodology provides a tool which could help make decisions for adaptation strategy implementation to preserve human life.
Utilization of Polyurethane Foam Dust in Development of Thermal Insulation Composite
Authors: Abu-Jdayil Basim , Al Abdallah Hyder , Mlhem Amal , Alkhatib Sarah , El Sayah Asmaa , Hussein Hend , Althabahi Asayel , AlAydaroos Alia
Published: January 2022

The massive production of Polyurethane foam from various products generates an extensive amount of waste, mostly in the form of dust that is emitted while cutting, trimming, or grinding the foam. In this research, the polyurethane dust (PUD) waste is incorporated into unsaturated polyester resin (UPR) to fabricate a heat insulation composite material to be used in construction. Filler percentages ranging from 10% to 50% were used to make the UPR-PUD composite materials. The thermal and mechanical properties of the material were studied in order to evaluate the ability of the composites for this type of application. Thermogravimetric Analysis and Differential Scanning Calorimeter tests were applied to determine the thermal stability of the material. In addition, the microstructure of the prepared composites and the incorporation of PUD filler into the polyester matrix were investigated by Scanning Electron Microscopy, X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR) analysis. The FTIR and XRD analyses suggested that adding PUD improved the curing process of unsaturated polyester and enhanced its crystalline structure. The experimental results showed promising thermal insulation capability, with low thermal conductivity in the range of 0.076 to 0.10 W/m·K and low water retention. Moreover, the composites exhibited compression strength between 56 and 100 MPa and tensile strength between 10.3 and 28 MPa, much higher than traditional thermal insulators and many building materials.
Carbon Peak and Carbon Neutrality in the Building Sector: A Bibliometric Review
Authors: Sun Zhaohui , Ma Zhili , Ma Minda , Cai Weiguang , Xiang Xiwang , Zhang Shufan , Chen Minxia , Chen Liming
Published: January 2022

Due to large energy consumption and carbon emissions (ECCE) in the building sector, there is huge potential for carbon emission reduction, and this will strongly influence peak carbon emissions and carbon neutrality in the future. To get a better sense of the current research situation and future trends and to provide a valuable reference and guidance for subsequent research, this study presents a summary of carbon peak and carbon neutrality (CPCN) in buildings using a bibliometric approach. Three areas are addressed in the review through the analysis of 364 articles published from 1990–2021: (1) Which countries, institutions, and individuals have conducted extensive and in-depth research on CPCN in buildings, and what is the status quo of their collaboration and contributions? (2) What subjects and topics have aroused wide interest and enthusiasm among scholars, and what are their time trajectories? (3) What journals and authors have grabbed the attention of many scholars, and what are the research directions related to them? Moreover, we propose future research directions. Filling these gaps will enrich the research body of CPCN and overcome current limitations by developing more methods and exploring other practical applications.
Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers
Authors: Lim Abner Herbert , Chan Jason Yongsheng , Yu Ming-Chin , Wu Tsung-Han , Hong Jing Han , Ng Cedric Chuan Young , Low Zhen Jie , Liu Wei , Vikneswari Rajasegaran , Sung Pin-Cheng , Fan Wen-Lang , Teh Bin Tean , Hsieh Sen-Yung
Published: January 2022

Background: Aristolochic acids (AAs) are potent mutagens commonly found in herbal plant-based remedies widely used throughout Asian countries. Patients and Methods: To understand whether AA is involved in the tumorigenesis of the oro-gastrointestinal tract, we used whole-exome sequencing to profile 54 cases of four distinct types of oro-gastrointestinal tract cancer (OGITC) from Taiwan. Results: A diverse landscape of mutational signatures including those from DNA mismatch repair and reactive oxygen species was observed. APOBEC mutational signatures were observed in 60% of oral squamous cell carcinomas. Only one sample harbored AA mutational signatures, contradictory to prior reports of cancers from Taiwan. The metabolism of AA in the liver and urinary tract, transient exposure time, and high cell turnover rates at OGITC sites may explain our findings. Conclusion: AA signatures in OGITCs are rare and unlikely to be a major contributing factor in oro-gastrointestinal tract tumorigenesis.