bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional characteristic of PC12 cells with reduced microsomal glutathione transferase 1.
Authors: Sobczak Monika , Boczek Tomasz , Ferenc Bozena , Taha Joanna , Kozaczuk Anna , Wiktorska Magdalena , Sacewicz-Hofman Izabela , Niewiarowska Jolanta , Zylinska Ludmila
Published: March 2019

Microsomal glutathione transferase 1 (MGST1) possesses glutathione transferase and peroxidase activities and is active in biotransformation of xenobiotics and in defense against oxidative stress. To assess MGST1 role in the development and functioning of PC12 cells, we constructed a cell line with reduced MGST1 (PC12_M). Real-time PCR and immunoblot assays showed MGST1 expression lowered to 60 % and immunocytochemical analyses demonstrated an altered concentration and distribution of the enzyme. PC12_M cells revealed a larger tendency to grow in clusters, weaker adhesion, irregular shape of bodies, short neurite outgrowth and higher percentage of necrotic cells (34 %). The total GSTs activity determined with non-specific substrate CDNB (1-chloro-2,4-dinitrobenzene) decreased by 15-20 %, whereas that with DCNB (2,4-dichloro-1-nitrobenzene), a substrate more specific for cytosolic GSTs, was similar to the one in control cells. This suggests that reduction of MGST1 cannot be compensated by other glutathione transferases. In PC12_M cells the total glutathione content was higher by 15-20 %, whereas the GSSG/GSH ratio was lower than in control cells. Moreover, the laminin-dependent migration rate was much faster in control cells than in PC12_M, suggesting some alterations in the metastatic potential of the line with suppressed MGST1. The amount of MAP kinases (p38, JNK, ERK1/2) was elevated in PC12_M cells but their phosphorylation level declined. Microarray analysis showed changed expression of several genes, which may be linked with differentiation and necrosis of PC12_M cells. Our data suggest that MGST1 could be an important regulator of PC12 cells development and might have significant effects on cell growth and proliferation, probably through altered expression of genes with different biological function.
Regulation of subcellular localization of muscle FBPase in cardiomyocytes. The decisive role of calcium ions.
Authors: Majkowski Michal , Wypych Dorota , Pomorski Pawel , Dzugaj Andrzej
Published: March 2019

Glyconeogenesis, the synthesis of glycogen from carbohydrate precursors like lactate, seems to be an important pathway participating in replenishing glycogen in cardiomyocytes. Fructose-1,6-bisphosphatase (FBPase), an indispensible enzyme of glyconeogenesis, has been found in cardiomyocytes on the Z-line, in the nuclei and in the intercalated discs. Glyconeogenesis may proceed only when FBPase accumulates on the Z-line. Searching for the mechanism of a FBPase regulation we investigated the effects of the calcium ionophore A23187, a muscle relaxant dantrolene, glucagon, insulin and medium without glucose on the subcellular localization of this enzyme in primary culture of neonatal rat cardiomyocytes. Immunofluorescence was used for protein localization and the intracellular calcium concentration was measured with Fura. We found that the concentration of calcium ions was the decisive factor determining the localization of muscle FBPase on the Z-line. Calcium ions had no effect on the localization of the enzyme in the intercalated discs or in the nuclei, but accumulation of FBPase in the nuclei was induced by insulin.
Risk Factors and Stress Management Among Hospital Nurses: A Systematic Review
Authors: Unggul Widodo I , . Pujiyanto
Published: March 2019

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Hepatitis B on Pregnant Women in Daerah Khusus Ibukota (DKI) Jakarta 2015
Authors: . Yusnabeti , Priyo Hastono S
Published: March 2019

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Tobacco Use and Adolescents in Indonesia: Narrative Review of Determinants
Authors: Rukmi S
Published: March 2019

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Correlation Between Hormonal Contraceptives Use and Age of Menarche with Breast Cancer Among Women in Indonesia: A Systematic Review
Authors: Ermi N , Kamso S
Published: March 2019

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Socio-demographic Characteristics of Unmet Need for Family Planning in Maluku, 2015
Authors: Pahlawaniati E , Prasetyo S B
Published: March 2019

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The Analysis of Chronic Energy Malnutrition and Iron Intake with Anemia in Preconception Women of Childbearing Age in Terbanggi Besar Subdistrict, District of Central Lampung
Authors: Isti Angraini D , Musyabiq Wijaya S
Published: March 2019

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Weather Implication for Dengue Fever in Jakarta, Indonesia 2008-2016
Authors: . Hasanah , Susanna D
Published: March 2019

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The Determinant of Trash Management at Faculty of Health Sciences in a University in Banyumas Regency
Authors: Dely Farhani S , Yuniarno S , Fitria Widiyanto A , Susanna D
Published: March 2019

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Management of Hypertension in the Elderly Patients: A Systematic Review
Authors: Dianah Z , Umami V
Published: March 2019

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Analysis of Manual Material Handling Technique and Its Association with Low Back Pain (LBP) Among Fisherman In Kangkung Village, Bandar Lampung
Authors: Mayasari D , Saftarina F , Indah Sari M , Sirajudin A
Published: March 2019

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Glomerulus Filtration Rate (GFR) Estimation Value Using Cockcroft and Gault Equation Against Community Exposure to Mercury at Artisanal and Small Scale Gold Mining (ASGM) Area in Lebaksitu Village, District of Lebak, Banten
Authors: Veronika E , Hartono B , Rahman A
Published: March 2019

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Does JKN Member’s Satisfaction on Healthcare Services Correlate with Sustainability of Premium Payment? Evidence from the Behavior of Self-Enrolled Member in Greater Jakarta Area
Authors: Nurhasana R , Hidayat B , . Pujiyanto , Dartanto T
Published: March 2019

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Tackling Non-communicable Diseases in Asia Countries Systematic Review
Authors: Ernita M , Wibowo A
Published: March 2019

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Section Cesarean in Urban Areas Indonesia: How the Relation with Frequencies of Antenatal Care?
Authors: Pristya T Y R , Fithriyatul Mas’udah A
Published: March 2019

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The Relationship Between Length of Hemodialysis Period, Diabetic Comorbidity, and Adequacy of Hemodialysis to the Changes of Sga Score on Hemodialysis Patients in Rsij Cp Hospital
Authors: . Sunarti , Arifah Pujonarti S
Published: March 2019

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Smoking Cessation Counseling Program: A Pilot Study on College Smokers
Authors: Surachman F , Anggadiredja K , Rahmawati S F , Zazuli Z
Published: March 2019

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Internet as an Effective Source of Health Information and Intervention in Several Countries: A Systematic Review
Authors: Ratri Renjana A
Published: March 2019

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The Analysis of Health Policy in the Border Area of West Kalimantan Indonesia
Authors: Rud A
Published: March 2019

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Correlation between Nutritional Status of Pregnant Mothers and Low Birth Weight in the Surakarta Hospital
Authors: Maryani F , Budi E , Sumiyarsi I
Published: March 2019

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Spatial Epidemiology Occurrences of a Disease Pulmonary TB Smear (+) and Implementation Overview of Case Finding at Ciputat Health Center South Tangerang City, Banten Province in 2009-2013
Authors: Handayani W , Tahangnacca M , Kusuma Wardhani R
Published: March 2019

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The Relationship between Individual Characteristic and Knowledge about HIV/AIDS with Condoms Usage Behaviour on FSWs (FSW)
Authors: Aryska W P , Ulfa L
Published: March 2019

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The Factors Correlated with the Number of Floor Germ in Nursing Room of Banyumanik Hospital, Semarang in 2007
Authors: Listyawati N S , Darundiati Y H
Published: March 2019

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Why is the Number of Patients of Methadone Maintenance Therapy in Indonesia Stagnant? Improvement of Service
Authors: Wulansari W , Rahmaniati Makful M
Published: March 2019

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The Effectiveness of the Maternity Public Health Nursing (MPHN) Module on Increasing the Nurse’s Knowledge, Attitude & Skills on Maternity Nursing Care in the Community: A Study in District of Cianjur, West Java, Indonesia
Authors: Melani Astari A , Rustina Y , Mariha T , Pratomo H , . Sabarinah
Published: March 2019

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Occupational Safety and Health Hazards and Musculoskeletal Disorders (MSDs) at Sprayed Work Farmer in Sumber Mufakat Village Kabanjahe 2016
Authors: Mahyuni E L
Published: March 2019

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Body Dissatisfaction and Perceived Stress Among Obese and Non-Obese University Students in Yogyakarta
Authors: Kusuma Wardani D A , Hastuti J
Published: March 2019

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“UMBIESS”: Innovations Drinks Product of Umbi As Community Empowerment Efforts in Gunungpati, Semarang City for Sustainable Development Goals (SDGs)
Authors: Najwat H , Hikmah L , . Budiyono
Published: March 2019

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Knowledge and Attitudes Toward Premarital Sex Behavior Students of SMAN “X” Jakarta
Authors: Kadarwati S R , Wuryaningsih C E , Alaydrus M
Published: March 2019

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The Description of Husband’s Knowledge and Support of Giving Exclusive Breastfeeding in Mekargalih, Jatinangor, Indonesia
Authors: Amelinda R H , Astuti S , Yuliani A
Published: March 2019

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Health Hazards Related to Workers’ Health
Authors: Kurniawidjaja L M , Ramdhan D H , Lestari F , Erwandi D , . Fitriyani , Dwirantih D , . Mulyana
Published: March 2019

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The Development of Malcolm Baldrige-Based Patient Safety Model in Basic Emergency Obstetric Care Community Health Center (BEOC-CHC). Preliminary Study: Implementation of Patient Safety in Padang
Authors: Anggraini Nursal D G , Machmud R , Darwin E , Mulyana N , Yolanda R
Published: March 2019

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Behavioral and Living Environmental Factors Associated with Dengue Haemorrhagic Fever Prevalence in Air Dingin Public Health Center, Padang City
Authors: . Masrizal , Wiratni I , Putra O
Published: March 2019

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The Utilization of Active Village Health Posts in Community Health Center Rumbia, Central Lampung
Authors: Yuliwati N , Dewi Sartika R A , Hassan A
Published: March 2019

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The Activity of Occupational Health Effort on Five Occupational Health Posts (Pos UKK) in Medan
Authors: Syahri I M , Fitria M
Published: March 2019

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Survey of Mental-Emotional Status of Junior High School Students in Bandung District, West Java Province, Indonesia
Authors: Gojali A R
Published: March 2019

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Women Empowerment and Contraceptive Use in Nusa Tenggara Barat 2013
Authors: Sholihah A E M , Eryando T , Damayanti R
Published: March 2019

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The Effect of Chicken Bone Powder Supplementation during Pregnancy and Lactation on the Calcium Level of Rat Pups’ Teeth
Authors: Atmokotomo P , Arlan A , Sitosari H , Haniastuti T , Linggar Jonarta A
Published: March 2019

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Association of Eating Pattern and Nutritional Status with Dyslipidemia Among Adults in Yogyakarta - Indonesia
Authors: . Susetyowati , Huriyati E , Josephine Istiti Kandarina B , Faza F
Published: March 2019

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Representation of Lymphocytes in Sinonasal Tissue of Chronic Rhinosinusitis Patients
Authors: Putu Lusy Indrawati L , Arfiana Nurul Fatimah V , Sianipar O
Published: March 2019

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Determination of the Best Nonlinear Function in order to Estimate Brahman Female Cattle Growth
Authors: Husaini Karim Amrullah A , Maharani D , Tri Widayati D
Published: March 2019

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Sustainable Control of the Golden Snail (Pomacea canaliculata Lamarck) on Irrigated Rice Field in Malaka Regency, East Nusa Tenggara Province, Indonesia
Authors: Wagiman F X , Ariani Bunga J , Hasoloan Purba Sidadolog J
Published: March 2019

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South Sea Pearl Shell Quality Inspection Using X–Ray Digital Radiography
Authors: Bayu Suparta G , Famelia Cerly M , Christian Louk A
Published: March 2019

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Growth Performance on Sapudi Ewe’s Birth Typein Sapudi Island, Madura, East Java, Indonesia
Authors: Muarifah H , Maharani D , Bintara S , Suparta Budisatria I G
Published: March 2019

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Potential of Weaver Ant (Oecophylla smaragdina Fabricius, 1775) as Biocontrol Agent for Pest of Teak Stand in Wanagama Forest, Gunungkidul, Yogyakarta, Indonesia
Authors: . Musyafa , Hasan Bahri S , Supriyo H
Published: March 2019

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Flowering of Two Cultivras of Durian (Durio zibethinus Rumph. ex Murray) Treated by Paclobutrazol
Authors: . Sakhidin , . Darjanto , Rohadi Suparto S
Published: March 2019

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Genetic Differentiation, Mating Systems and Crossability of Three Floral Variants of Sandalwood (Santalum album L.) in Gunung Sewu Geopark, Indonesia
Authors: Indrioko S , Nurcahyani Cahyaningrum Y W
Published: March 2019

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Seed Characteristics of Soybean Cultivars As Affected by Foliar Application of Elicitors
Authors: Hasanah Y , Aziz Mahmud Siregar L , Mawarni L
Published: March 2019

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بررسی عوامل مؤثر بر پرداخت از جیب بیماران در بیمارستان¬های تابعه دانشگاه علوم پزشکی مازندران
Authors: علیخانی نیلوفر , عباسی محیا , فتحی علیرضا
Published: March 2019

زمینه و هدف: پرداخت­ مستقیم از جیب، از روش­های مهم پرداخت در نظام سلامت ایران به‌شمار می­رود که تأثیرات منفی بر برابری داشته و گروه­های آسیب­پذیر را به‌ سمت فقر سوق می­دهد. با توجه به اهمیت این روش به‌عنوان یکی از کلیدی­ترین موضوعات سیاستگذاری­های سلامت، مطالعه حاضر در راستای شناسایی عوامل مؤثر بر پرداخت­هاي مستقیم خانوار، انجام شد.
روش پژوهش: این پژوهش، توصيفي- تحليلي بوده و به‌صورت مقطعي بر روی اطلاعات جمع آوری شده معاونت درمان دانشگاه علوم پزشکی استان مازندران مربوط به 4 دوره 1 ساله (1395-1392) انجام شد. جامعه آماری شامل تمام بیمارستان­های دولتی تابعه دانشگاه علوم پزشکی مازندران بود. ابزار جمع­آوری داده­ها، برخی شاخص­های عملکردی بیمارستان­ بود که پس از جمع­آوری، اطلاعات مربوطه، وارد نرم­افزار Eviews 6 شد و برای تحلیل داده­ها از روش حداقل مربعات استفاده شد.
یافته‌ها: بر اساس یافته­های پژوهش، 73 درصد از تغییرات پرداخت از جیب بیماران توسط متغیرهای مستقل مطالعه، توضیح داده شد. متغیرهای تعداد پزشک متخصص، تخت روز کل و طول مدت اقامت بیمار در بیمارستان بر پرداخت از جیب بیماران تأثیر معنی‌داری داشتند (05/0 > p) و ارتباط بین متغیرهای تخت فعال، تخت روز اشغالی و درصد اشغال تخت و پرداخت از جیب، معنی‌دار نبود (05/0 < p).
نتیجه گیری: پرداخت مستقیم از جیب، پیچیده و معلول فاکتورهای مختلفی بوده و نیاز است که این فاکتورها مورد بررسی قرار گیرند تا با شناسایی و کنترل عوامل تعیین­کننده پرداخت­ها و تعیین استراتژی­های مناسب بتوان آن را تا حد ممکن کنترل نمود.
بررسی آثار متقابل بین مؤلفه‌های اثرگذار بر تصمیم پزشکان جهت مشارکت در طرح پزشک خانواده و ویژگی‌های دموگرافیک آن‌ها با استفاده از آزمون انتخاب گسسته
Authors: رنجبر محمد , رفیعی سیما , پاکدامن محسن , اثرکار فاطمه
Published: March 2019

زمینه و هدف: با توجه به نقش و جایگاه پزشکان عمومی در طرح پزشک خانواده، شناخت و آگاهی از مؤلفه‌هاي اثرگذار بر تصمیم آن‌ها جهت ورود به این طرح، براي سیاستگذاران و برنامه ریزان از اهمیت به‌سزایی برخوردار است. هدف این پژوهش شناسایی مؤلفه‌های اثرگذار بر تصمیم پزشکان عمومی و همچنین تعیین اثر متقابل بین این مؤلفه‌ها و ویژگی‌های دموگرافیک پزشکان شاغل در دانشگاه علوم پزشکی یزد جهت مشارکت در طرح پزشک خانواده بود.
روش پژوهش: پژوهش حاضر از نوع توصیفی می‌باشد. این پژوهش بر روی 137 پزشک عمومی که به صورت سرشماری وارد مطالعه شده‌اند، با استفاده از تکنیک آزمون انتخاب گسسته در سال 1396 انجام گرفت. جمع آوري اطلاعات از طریق پرسشنامه‌اي که با استفاده از روش ارتوگونال به‌وسیله نرم افزار SPSS 24 طراحی شده بود، انجام گرفت. تجزیه و تحلیل داده‌ها نیز با استفاده از مدل رگرسیون لوجیت به‌وسیله نرم افزار  Stata 13 انجام شد.
یافته‌ها: یافته‌ها نشان داد که مؤلفه "حقوق دریافتی بالاتر" برای پزشک عمومی مرد، پزشکان متأهل و پزشکانی با درآمد بالاتر مطلوبیت بالاتری ایجاد می‌کند. همچنین پزشکان متأهل به طور معنی‌داری تمایل بیشتری برای ارائه خدمات خارج از بسته و استفاده از تسهیلات مسکن و ایاب و ذهاب دارند. از طرفی پزشکان متأهل تمایل چندانی برای ادامه تحصیل و استفاده از سهمیه جهت قبولی در دوره تخصص ندارند. همچنین بین محل خدمت و وضعیت تأهل نیز رابطه معکوس و معنی داری وجود داشت.
نتیجه گیری: طراحی برنامه با در نظرگرفتن ویژگی‌هاي دموگرافیک پزشکان عمومی، می‌تواند با افزایش احتمال حضور پزشکان عمومی در طرح، همراهی بیشتر ایشان را براي پیاده سازي آن در پی داشته باشد. با توجه به تأکید قوانین بالادستی کشور مبنی بر لزوم اجراي برنامه پزشک خانواده و همچنین نقش و جایگاه مهم پزشکان عمومی در شکل گیري و اجراي موفقیت آمیز این برنامه، چنانچه سیاستگذاري در این حوزه به گونه‌اي انجام پذیرد که متغیرهاي دموگرافیک را در نظر گرفته باشد، این برنامه جذابیت بیشتري براي تعداد بیشتري از پزشکان خواهد داشت.
Olhares para o Retorno do Pêndulo: reflexões a partir de Bauman e Dessal
Authors: Tedesco Sirlei , Da Rosa Geraldo Antônio
Published: March 2019

Nesse texto apresentamos a resenha da obra: DESSAL, Gustavo; BAUMAN, Zygmunt. O Retorno do Pêndulo: sobre a Psicanálise e o Futuro do Mundo Líquido. Tradução: Joana Angélica D’Ávila Melo. Rio de Janeiro: Zahar, 2017.
Relation between work efficiency and labor cost in Poland
Authors: Kapela Magdalena
Published: March 2019

The basic goal of this document is to research the changes in work efficiency level, as well as labor costs and evaluation of their relation in Poland in comparison to other EU countries. Research period embraced the years 2000–2016. Desired research objective was achieved with the use of review of the literature method, deduction, description and simple statistical and visualization technics (Eurostat, GUS). The analysis of changes and proportions between unit labor costs and labor productivity is essential element of labor market researches. Sustainable and monochromic growth of both factors is important if competitiveness’s improvement ought to be due to technology development not to low-wages politic. Polish production is based on low and middle technology, and until now low labor costs. This system can turn out negative and embed unfavorable economy structure. The level of unit labor costs in Poland in comparison to European Union is low, so as the level of work productivity is. On the other hand the pace of labor productivity is high. Until now the pace of wage growth was lower than labor efficiency, and the balance between two variables was kept.
Disidencia de sexo-género e identidad política en Kleinstadtnovelle de Ronald Schernikau
Authors: Rubino Atilio Raúl
Published: March 2019

Kleinstadtnovelle de Ronald Schernikau se publica en 1980, año bisagra entre la década de la Schulewebegung en Alemania y una creciente normalización transnacional de lo gay que dará como resultado en Estados Unidos la perspectiva de los Estudios y la militancia queer. Este artículo realiza un recorrido por los movimientos de liberación gay-lésbica de la década del setenta en Alemania para luego analizar cómo en el texto literario de Schernikau se puede ver que a comienzos de los ochenta ya comenzaban a operarse nuevos regímenes de producción e inteligibilidad de lo humano. Dentro de estos nuevos regímenes parece seguir operando la lógica de la vergüenza y la discreción así como la normalización de la homosexualidad siguiendo los parámetros de la vida normal heterosexual. Se trata de una época en donde ya la sexualidad comienza a ser tema de debate en los medios de comunicación y, con ello, se convierten éstos en un nuevo saber/poder. En este contexto, la identidad se vuelve una fuerte arma de lucha política.
Foucault
Authors: Páez Guzmán Esaú Ricardo
Published: March 2019

¿Cómo soltar amarras y dejarnos llevar por el ritmo de una sonrisa, más allá de la resignación y de la burla, allí donde el niño juega  a hacer maldades, allí en donde Alonso Quijada pule sus armas del orín y del moho y allí donde el coronel Aureliano, mientras espera un telegrama, juega con un pescadito de oro en el bolsillo? ¿Cómo saltar en las sabidas transformaciones del camello y del león y entrar en la última, en la que el niño se afirma en su despiadada inocencia? ¿Cómo “no se ha de hablar como lo niños”? (Nietzsche, 1984, pp. 31-38).
Biosimilar Agents for Psoriasis Treatment: The Perspective of Portuguese Patients
Authors: Azevedo Alexandra , Bettencourt Andreia , Selores Manuela , Torres Tiago
Published: March 2019

Introduction: Biosimilars are highly similar copies of previously approved original biologic medicines. Their introduction on the market may yield cost reduction. The aim of this study was to evaluate the perspectives of psoriasis patients on biosimilar medications.Materials and Methods: We conducted a 14 questions survey of psoriasis patients receiving biological therapy and followed-up in a dermatology department of a Portuguese tertiary care hospital.Results: From a total of 108 patients included, 70.4% of patients did not know the definition of biosimilar agent and 76.6% of patients showed partial or total interest in using a biosimilar drug. Nearly 80% of patients partially or totally agreed in using a biosimilar drug in order to reduce healthcare costs with psoriasis treatment. However, the lack of studies in the European population and in psoriatic patients led most of the patients (72.2% and 75.0%, respectively) to somewhat or completely oppose to the use of biosimilars. Demographic variables, household income and type of current biologic therapy did not affect patient preferences.Discussion: Despite of the unfamiliarity of the respondents with biosimilars, most patients seem receptive to their use. Nevertheless, there are two issues of concern: i) the use of biosimilars that are not tested in a European population, and ii) its approval for psoriasis without trials in this disease. Thus, an immediate need exists for patient education about biosimilars.Conclusion: Biosimilars may increase patient access to biologic therapies. Improved communication and the involvement of patients in decision-making regarding biosimilars may increase their acceptance in future.
Dermatoses em Africanos / Dermatoses in Africans
Authors: Pinto Ana Marcos- , Ortins-Pina Ana , Borges-Costa João
Published: March 2019

ResumoAtualmente, devido aos circuitos migratórios cada vez mais frequentes na Europa e consequente aumento da população migrante em Portugal, principalmente na área metropolitana de Lisboa, é cada vez mais comum depararmo-nos com diversas patologias dermatológicas nos indivíduos africanos que recorrem ao sistema de saúde. Existem poucos estudos sobre dermatoses nesta população.É importante conhecer as diferenças biológicas e fisiológicas da pele negra, de modo a compreender a fisiopatologia e a manifestação das dermatoses. O diagnóstico de muitas delas constitui um desafio para qualquer clínico devido às características especificas da sua pele. É essencial conhecer os diferentes padrões e frequências das doenças cutâneas em africanos, de modo a otimizar os seus diagnóstico, abordagem e tratamento.
Marjolin’s Ulcer with Axillary Lymph Node Metastasis
Authors: Fernandes Manuela Graça , Brandão Mariana , Dias Eduardo Mijare
Published: March 2019

N/A.
Moderate to Severe Cancer Pain: Are We Taking Serious Action? The Opioid Prescribing Scenario in Portugal
Authors: Reis-Pina Paulo , Lawlor Peter G. , Barbosa António
Published: March 2019

N/A.
The Future of Medical Publishing
Authors: Groves Trish
Published: March 2019

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Carta ao Editor Relativa ao Artigo: “Saúde Oral - Fatores de Não Adesão aos Cheques-Dentista: Um Estudo de Caso-Controlo” de Rita Filipe e Pedro Aguiar. Acta Med Port 2018 Jun;31(6):303-311.
Authors: Prazeres Filipe
Published: March 2019

N/A.
Erratum to “Clinical Presentation and Long-Term Outcomes of Systemic Sclerosis Portuguese Patients from a Single Centre Cohort: A EUSTAR Registration Initiative”
Authors: Vidal Carolina , Ruano Carina , Bernardino Vera , Lavado Carreira Pedro , Lladó Ana , Santos Maria Céu , Gruner Heidi , Panarra António , Riso Nuno , Moraes-Fontes Maria Francisca
Published: March 2019

Article published with errors: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10658On page 312, where the authors’ line reads as:Carolina VIDAL1, Carina RUANO2, Vera BERNARDINO3, Pedro LAVADO CARREIRA3, Ana LLADÓ3, Maria Céu SANTOS4, Heidi GRUNER3, António PANARRA3, Nuno RISO3, Maria Francisca MORAES-FONTESAC,1It should read:Carolina VIDAL1,2, Carina RUANO3, Vera BERNARDINO1, Pedro LAVADO CARREIRA1, Ana LLADÓ1, Maria Céu SANTOS4, Heidi GRUNER1, António PANARRA1, Nuno RISO1, Maria Francisca MORAES-FONTESAC,1 On the same page, where the authors’ affiliation on the footer reads as:Serviço de Medicina Interna. Hospital do Divino Espírito Santo de Ponta Delgada. São Miguel. Portugal.Serviço de Radiologia. Hospital de Santa Marta. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.Unidade de Doenças Auto-Imunes/Serviço Medicina 7.2. Hospital de Curry Cabral. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.Laboratório de Imunologia. Centro Hospitalar de Lisboa Central. Lisboa. Portugal. It should read:Unidade de Doenças Auto-Imunes/Serviço Medicina 7.2. Hospital de Curry Cabral. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.Serviço de Medicina Interna. Hospital do Divino Espírito Santo de Ponta Delgada. São Miguel. Portugal.Serviço de Radiologia. Hospital de Santa Marta. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.Laboratório de Imunologia. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.
Ditames Éticos e Jurídicos na Relação do Médico com as Redes Sociais: Quantos “Likes” Eu Mereço?
Authors: Durão Carlos , Braz Lamarca Rafael da Costa
Published: March 2019

N/A.
Severe Postpartum Coagulopathy Without Haemorrhage: A Case Report
Authors: Lérias-Cambeiro Muriel , Rodrigues Anabela , Taborda Inês , Lança Filipa
Published: March 2019

Postpartum haemorrhage is an important health issue worldwide, and it can be caused by uterine atony, retained placental tissue, trauma or coagulation disorders. Although coagulopathy represents a rare cause, it is a significant contributor to postpartum haemorrhage with poor outcomes. Associated with high morbidity and mortality rates, postpartum haemorrhage demands prevention, prompt diagnosis and effective management. We describe a unique case of severe coagulopathy caused by underestimated blood loss during caesarean section without postpartum bleeding, in which transfusion requirements were thromboelastometry-guided. This case report depicts how an early multidisciplinary approach and patient-centred care in an obstetric emergency contributes to a positive outcome from a challenging situation, enabling the prevention of an imminent, catastrophic haemorrhage.
On codes over the finite non chain ring A = F4+vF4; v2 = v and its covering radius of codes with Bachoc weight
Authors: Chella Pandian P
Published: March 2019

In this paper, some lower and upper bounds on the covering radius of codes over the nite non chain ring A = F4 + vF4; v2 = v with respect to Bachoc weight is given. Also, the covering radius of various Block Repetition Codes of same and different length over the nite non chain ring A = F4 + vF4; v2 = v is obtained.In this paper, some lower and upper bounds on the covering radius of codes over the nite non chain ring A = F4 + vF4; v2 = v with respect to Bachoc weight is given. Also, the covering radius of various Block Repetition Codes of same and different length over the nite non chain ring A = F4 + vF4; v2 = v is obtained.
Mechanical properties of self-curing concrete (SCUC)
Authors: Elwakkad Noha Yehia , Heiza Khaled Mohamed
Published: March 2019

According to lack of water, labor self curing concrete (SCUC) is necessary in construction projects. In this study, it is focuses on concrete application with new admixture to achieve SCUC. The present study involves the use of shrinkage reducing admixture polyethylene glycol (PEG 400) in concrete which helps in self curing and helps in better hydration and hence strength. The effect of admixture (PEG 400) on water retention, compressive strength, split tensile strength and modulus of rupture by varying the percentage of PEG by weight of cement from 0% to 1% were studied for M1 and M2 mixes. It was found that using PEG400 with dosage 0.3%, 0.5% gives an early strength to the concrete. It was also found that 0.5% of PEG 400 by weight of cement was the optimum for both M1 and M2 mixes.
Steel scrap added roller compacted concrete
Authors: Armagan Kemal , Yıldızel Sadık Alper , Arslan Yusuf
Published: March 2019

The purpose of this paper is to investigate the benefits of using steel slag as an additive in Roller Compacted Concrete (RCC) which is a promising material can be used in streets, local roads, residential streets, high-volume roads, industrial access roads, airports...etc. The mechanical performances of steel scrap added reinforced cementitious composites produced with an industrial punch scrap. In specimen mixtures two types of scraps with diameters of 5 mm and 7 mm were used. The additive was mixed with 1%, 1.5% and 2% ratios by weight. Due to the results of the study, it was obtained that flexural strength properties of the specimens have increased up to 11%. In addition, freeze thaw effect of the specimens was investigated and found that 2% percent of scrap usage was given the best results.
RKKY Interaction in Graphene at Finite Temperature
Authors: Kogan Eugene
Published: March 2019

In our publication from 8 years ago1 we calculated RKKY interaction between two magnetic impurities in graphene. The consideration was based on the perturbation theory for the thermodynamic potential in the imaginary time representation and direct evaluation of real space spin susceptibility. Only the case of zero temperature was considered. We show in this short notice that the approach can be easily generalized to the case of finite temperature.
Sevilla extramuros en el siglo XVI: tres vistas del Civitates Orbis Terrarum
Authors: Gámiz Gordo Antonio , Díaz Zamudio Tomás
Published: March 2019

A finales del siglo XVI se publicó una importante obra conocida como Civitates Orbis Terrarum, con tres vistas de Sevilla de gran valor documental –dos de Hoefnagel y una copiada de Brambilla– que detallaron con verosimilitud su periferia urbana, junto a textos explicativos. Tras revisar su contexto, por primera vez se analiza el territorio extramuros representado: puerto, arrabales, murallas e hitos arquitectónicos en un entorno de carácter agrario. Además se consideran otras vistas y plagios, localizando sus miradores sobre aquel paisaje poco conocido y transformado por la ciudad actual.
Propuesta metodológica para la identificación, caracterización y cualificación de los paisajes: la cuenca endorreica de Padul (Andalucía) como caso de estudio
Authors: Arias-García Jonatan
Published: March 2019

Se presenta una propuesta metodológica que permita identificar, caracterizar y cualificar los paisajes en las cuencas hidrográficas de tipo endorreico y sus humedales asociados. La metodología, que considera la posibilidad de implementar el Convenio Europeo del Paisaje, consta de dos etapas: identificación y caracterización; y valoración y propuestas. La primera etapa consiste en la delimitación de unidades de paisaje y su clasificación en Tipos y Áreas de acuerdo con la metodología LCA (Landscape Character Assessment); caracterización e integración multiescalar. La segunda etapa tiene como objetivo establecer una valoración y significación de estos paisajes a partir de su cualificación y establecimiento de objetivos de calidad paisajística. El método propuesto ha permitido establecer una perspectiva transversal del análisis paisajístico al desarrollar: un ejercicio descriptivo-analítico de los fundamentos naturales del paisaje, procesos histórico-socioeconómicos y escénico-visuales; un ejercicio de diagnóstico atendiendo a la transformación de las bases naturales del paisaje (geosistemas o unidades ecogeográficas originales); y un ejercicio propositivo que contempla la valoración del paisaje y sus posibilidades de actuación.
Metodología para la predicción de puntos de riesgos múltiples en infraestructuras viarias tras episodios torrenciales (road-risk)
Authors: Perles Roselló María Jesús , Pardo García Santiago Manuel , Mérida Rodríguez Matías , Olcina Cantos Jorge
Published: March 2019

Se presentan los contenidos de una metodología que permite predecir y cartografiar aquellos puntos en el recorrido de una infraestructura viaria susceptibles de quedar bloqueados por riesgos tras episodios de precipitación torrencial. Se consideran los riesgos de movimiento en masa, subsidencia del firme, generación de balsas e inundación por desbordamiento de cauces aledaños. Para estimar las consecuencias en cada punto, se evalúan tanto factores de peligrosidad como de vulnerabilidad del medio humano frente al potencial corte de tráfico. Se ha diseñado, además, una aplicación informática que implementa la metodología obtenida y facilita su aplicación a otros casos.
Estudiantes universitarios y su importancia en los cambios barriales: ¿hacia nuevos modelos de gentrificación en espacios periféricos?
Authors: Prada-Trigo José
Published: March 2019

Este artículo analiza e interpreta los cambios producidos en el barrio de Agüita de la Perdiz (Concepción - Chile), como consecuencia de la llegada de estudiantes universitarios al mismo. Pese a que los estudios anglosajones han puesto de manifiesto en los últimos años la importancia de los llamados procesos de studentification como detonantes de transformaciones físicas, sociales, económicas y culturales en los barrios, asimilándolos en ocasiones a manifestaciones globales de un fenómeno de gentrificación, apenas existen estudios desde otros contextos socioespaciales. A partir de estas premisas, el presente trabajo analiza e interpreta estos aspectos mediante una metodología que combina el uso de datos cuantitativos y cualitativos, obteniendo unos resultados que ratifican la existencia de algunas transformaciones que también se dan en otros casos de estudio, junto con otras particulares, explicables por la propia singularidad del barrio e identificables con el carácter socialmente periférico y el propio origen informal del caso analizado.
Novel Nano-Capsules for Oil Field Chemicals Delivery and Slow Release
Authors: AlJabri Nouf , Chang Yun
Published: March 2019

Chemicals in oil fields have shown a great potential for enhancing/improving oil recovery (EOR/IOR) beyond waterflood baseline. The objectives of this work are: (1) to develop a cost-effective method to deliver chemicals to deeper layers in reservoirs compared to conventional chemical operations, (2) to synthesize nano-capsules with improved stability under typical reservoir temperatures (80-110 °C), and (3) to demonstrate the gradual release of EOR/IOR chemicals over time at a given temperature within the above range. Multiple slow-release technologies were developed; (1) Nano-salt (2) liposomes and (3) nano-capsules. In the first method, nano-size surfactant salt particle that has a limited solubility can traverse the reservoir and deliver, over a long period of time, a constant concentration of surfactant was synthesized. In addition to surfactant salts, surfactant-loaded nano-capsules were synthesized by dissolving a known lipid formula in 20.0 mL chloroform, then, evaporating the solvent to form a dried lipid film. Acid nano-capsules for improving oil recovery operations were synthesized using In situ and interfacial polymerization. Scanning electron microscopy, an optical microscopy, dynamic light scattering, Inductive coupled plasma (ICP-AES), pH and surfactant electrodes were used to characterize the nano-capsules and dispersion. To assist the nano-platforms slow-release profile and the particles stability under reservoir conditions, the samples were incubated in oven at 95 °C. The nano-capsules’ slow-release and stability were monitored for several days. The liposomes contain 11 wt. % of PETRONATE® EOR2095 with particles’ average size of ~80 nm, the surfactant released was gradually increased over sixty hours. The acid nano-capsules contain 15 wt. % acid precursor with particles’ average size of 200 nm. The capsules release versus time curve showed that the release occurred when the temperature reached 95 °C, indicating that nano-capsules’ release is triggered by the temperature increment. The pH versus time release curve exhibits a gradual decreasing in the pH over six day indicating the acid precursor hydrolysis at 95 °C. Our results demonstrate the possibility of improving current chemicals flood via nano-encapsulation. The slow release technology may bring new potentials to the current hydrocarbon production operations.
Characterization and Comparison of Outcrop and Subsurface Unconventional Shale Samples
Authors: Jin Yan , Jin Guodong , Syed Shujath Ali , Jin Miao , Hussaini Syed Rizwanullah
Published: March 2019

Subsurface unconventional shale samples are always scarce. Outcrop analogs are often used as an alternative to enhance the understanding of the corresponding reservoir formation. One assumption is usually made that rock composition and properties between the outcrop and subsurface samples remain the same or similar, despite differences in their burial and diagenetic histories. This paper presents a comparative case study to investigate the similarities and differences in rock properties between outcrop and subsurface samples from the same formation.

Two subsurface and two outcrop samples from the Lower Silurian Longmaxi formation in Sichuan Basin of China were characterized to determine their mineralogical, geochemical, petrophysical, elastic and mechanical properties. Micro-CT images showed that one subsurface sample was drilled normal to the bedding, while other three samples were parallel to the bedding. Two subsurface samples differ in their mineralogy – the horizontal sample is clay-dominant, while the other one is predominantly comprise of quartz, dolomite and calcite minerals, very similar to two outcrop samples. All four samples are thermally immature and their Tmax is less than 435 °C. Subsurface samples have the highest TOC of 3.75% but relatively lower HI and OI. Other pyrolysis parameters are very similar between subsurface and outcrop samples. All samples have very low porosity of less than 2.5% and permeability of less than 9 nD, although subsurface samples have a relatively higher value.

The discrepancy in mineralogical composition, especially the clay content, results in different elastic and mechanical behavior of outcrop and subsurface samples. The subsurface sample is highly anisotropic in both compressional and shear wave anisotropy due to the large amount of clay minerals, while one outcrop sample exhibits the strong shear wave anisotropy only and the other one is almost isotropic. Subsurface samples have lower values of Young's modulus, peak stress, Mohr-Coulomb failure parameters and unconfined compressive strength than outcrop samples.
Unlocking Tight Carbonate Reservoir Potential: Geological Characterization to Execution
Authors: Latief Agus Izudin , Syofyan Syofvas , Tengku Ab Hamid Tengku Mohd , Ahmed Al Amoudi Mohsen , Ali Shabibi Tariq
Published: March 2019

The reservoir in discussion is a tight carbonate reservoir with low productivity and relatively under-developed albeit the huge in-place volumes. The expectation is that a detail reservoir characterization will provide insight on factors affecting reservoir productivity, spatial distribution of productive portion of the reservoir and offering solution to overcome reservoir tightness.

The case study discusses on how a comprehensive multi-discipline review unravels and presents a robust reservoir heterogeneity framework. A geological review that includes both depositional and diagenetic process is performed to understand distinct components/factors responsible for reservoir heterogeneity. Simultaneously, petrophysical assessment was performed to quantitatively define rock grouping based on porosity-permeability, capillary pressure and pore throat distribution in the log and core domain.

The multi-discipline observations were then reconciled to establish relationship between the process origin and the resultant product of specific group/range of reservoir petrophysical properties. The multitude of pore throat characters and its petrophysical properties were linked to the underlying geological processes. The established heterogeneity framework provides clarity on spatial distribution of the reservoir sweet-spot, factors controlling low productivity and the required mitigation.

The study provides a complete journey of unlocking tight reservoir potential. It illustrates the geological studies influence toward innovative completion technology selection, design, and execution to overcome reservoir challenge. The study is supported by recent drilling and test results, hence offering insight for adoption and lesson learned.
Application of High Performance Asynchronous Acoustic Wave Equation Stencil Solver into a Land Survey
Authors: Abdelkhalak Rached , Akbudak Kadir , Etienne Vincent , Ltaief Hatem , Tonellot Thierry , Keyes David
Published: March 2019

This paper describes the application of high performance asynchronous stencil computations for 3D acoustic modeling on a synthetic land survey. Using the Finite-Difference Time-Domain (FDTD) method, a parallel Multicore Wavefront Diamond-tiling (MWD) stencil kernel (Malas et al. 2015, Malas et al. 2017) drives the high performance execution using temporal blocking to maximize data locality, while reducing the expensive horizontal data movement. As absorbing boundary conditions, we use Convolutional Perfectly Matched Layer (CPML), which have to be redesigned to not interrupt the asynchronous execution flow engendered by the MWD stencil kernel for the inner-domain points. The main idea consists in weakening the data dependencies by moving the CPML computations into the inner-computational loop of the MWD stencil kernel (Akbudak et al. 2019). In addition to handling the absorbing boundary conditions, applying the asynchronous MWD with CPML kernels to a realistic land survey requires the extraction of the wavefield value at each receiver position. We revisit the default extraction process and make it also compliant with the overall asynchrony of the 3D acoustic modeling. We report performance improvement up to 24% against the standard spatial blocking algorithm on Intel multicore chips using the synthetic land survey, which is representative of an area of interest in Saudi Arabia. While these results concur with previous performance campaign assessment, we can actually produce and assess the resulting 3D shot gather accuracy. To our knowledge, this is the first time the effectiveness of asynchronous MWD stencil kernel with CPML absorbing boundary conditions is demonstrated in an industrial seismic application.
Data and Model Integration Challenges for Integrated Production Forecasting-Experience from Super-Giant Onshore Fields
Authors: Reddicharla Nagaraju , Cornwall Rachelle Christine , Rubio Erismar , Soni Sandeep , Isambertt Jose
Published: March 2019

To optimize production of a supergiant field, operators require an integrated approach to production forecasting that incorporate subsurface models of multiple reservoirs, well performance, surface equipment and facility constraints. This helps asset managers plan and optimize production on a well-by-well basis to achieve maximum system deliverability. This paper addresses challenges of integrating huge amounts of data, model framework and automated workflows to identify opportunities in debottlenecking, production target sustainability and deliverability.

The integrated production system model involves a simplistic bottom-up approach, in which advanced integration of subsurface and surface elements was facilitated through automated workflows within a digital oilfield system. These automated workflows enable converting multiple reservoir simulation output files to a standard format and mapping of common well names in simulation outputs and in well and facility models. An event-controlled scheduling process in a single working environment enabled analysis of production targets in realistic facility situations for future time steps. The decline in reservoir pressure is modeled, with new well performance in facility model based on changing reservoir conditions.

This automated environment has been adapted to evaluate two giant onshore fields encompassing multiple reservoirs, thousands of wells and numerous distributed-process facilities. The forecasting process confirms deliverability of planned and sustainable production and identifies opportunities for additional field potential, thus facilitating CAPEX optimization for future well costs. The integrated asset forecast was successfully carried out over a five- year timeframe at monthly intervals. One of the most important results obtained from such a forecast simulation was obtaining the maximum feasible rates that can be expected from the asset for each month during the next five years. This collaborative solution has successfully demonstrated the value of data and software integration, and addressed the challenges in integrated production forecasting. The results prove that this is a powerful tool for short- and medium- term forecasting, enabling asset managers to plan field operations, drilling, workovers, and facility improvement projects

This paper describes an integrated production forecasting setup. The case study explains process steps, challenges, simplification and results. The modeling and integration process enables the asset operator to plan remedial subsurface and surface projects to sustain planned rates over time. The forecasting process helps in quick business decision making, thus minimizing uncertainties in deliverability of future production mandates and highlights production-enhancement opportunities.
Use of Geological Constraints in Multi-Mineral Modeling for Unconventional Reservoirs
Authors: Hao Zhang , Nora Alarcon , Freddy Mendez , Amer Hanif
Published: March 2019

Determination of mineral rock composition is an important part of unconventional reservoir formation evaluation because the mineral composition affects hydraulic fracture generation and propagation. Two types of models are usually used for mineralogy modeling—deterministic and stochastic. Both models apply mathematical representations of the logging tool responses; however, stochastic modeling has become more popular due to its consideration of random distributions in the predictor and target variables. Stochastic mineralogy modeling algorithms usually produce solutions by minimizing a function reflecting the differences between the measured and modeled responses. However, due to the non-uniqueness inherent in inversion methods, the solution may not provide petrophysically meaningful results. To avoid producing compromised results, the use of geological constraints is proposed to represent the geological relations between the unknown parameters (inversion variables), leading to a more meaningful mineralogy model.

The proposed algorithm incorporates probability functions to generate mineralogical solutions representing geologically and petrophysically sound results. The weight assigned to the penalties in the cost function depends on the probability function assigned to the constraints. Two models are presented using the proposed algorithm: a pyrite-anhydrite constraint based on the iron and sulfur ratio, and a K-feldspar-albite constraint based on the thorium and potassium ratio.

Data sets from several different shale plays, from across North America, are processed using the proposed algorithm. The mineral sets are complex and vary from one play to another. The results show excellent agreement with the available core X-ray diffraction measurements. The study demonstrates that the proposed constraints provide an effective improvement, in integrated formation evaluation, especially in unconventional reservoirs with highly complex mineralogy.