bluuebunny/crossref_metadata_2025 huggingface dataset:
Keyboard Model of Seismic Cycle of Great Earthquakes in Subduction Zones: Simulation Results and Further Generalization
Authors: Lobkovsky Leopold I. , Vladimirova Irina S. , Gabsatarov Yurii V. , Alekseev Dmitry A.
Published: October 2021

Catastrophic megaearthquakes (M > 8) occurring in the subduction zones are among the most devastating hazards on the planet. In this paper we discuss the seismic cycles of the megathrust earthquakes and propose a blockwise geomechanical model explaining certain features of the stress-deformation cycle revealed in recent decades from seismological and satellite geodesy (GNSS) observations. Starting with an overview of the so-called keyboard model of the seismic cycle by L. Lobkovsky, we outline mathematical formalism describing the motion of seismogenic block system assuming viscous rheology beneath and between the neighboring elastic blocks sitting on top of the subducting slab. By summarizing the GNSS-based evidence from our previous studies concerning the transient motions associated with the 2006–2007 Simushir earthquakes, 2010 Maule earthquake, and 2011 Tohoku earthquake, we demonstrate that those data support the keyboard model and reveal specific effect of the postseismic oceanward motion. However, since the seismogenic blocks in subduction systems are mostly located offshore, the direct analysis of GNSS-measured displacements and velocities is hardly possible in terms of the original keyboard model. Hence, the generalized two-segment keyboard model is introduced, containing both frontal offshore blocks and rear onshore blocks, which allows for direct interpretation of the onshore-collected GNSS data. We present a numerical computation scheme and a series of simulated data, which exhibits the consistency with measured motions and enables estimating the seismic cycle characteristics, important for the long-term earthquake forecasting.
Equivalent Black Carbon Aerosol Properties and Their Relationship with the Heating Season in Urban Environments
Authors: Chen Wei , Song Ge , Zhao Haimeng , Sun Shanlin , Wu Yi
Published: October 2021

Black carbon (BC) aerosols have a considerable impact on humans because they not only cause environmental pollution and reduce visibility but also harm human health. During the heating season in northern China, a large amount of coal is burned for heating, producing a large amount of BC. There are few studies on BC properties during the heating season. In this paper, BC is measured optically, so it is referred to as equivalent black carbon (EBC). This paper investigated EBC properties in depth during the heating and nonheating seasons of a typical urban environment in China with two years of EBC measurements. The results show that: (1) EBC aerosol concentrations during the heating season were significantly higher than those during the nonheating season. (2) The main sources of EBC aerosols throughout the year are liquid sources. During the heating season, solid sources (coal and biomass combustion) are dominant. (3) The proportion of brown carbon (BrC) produced by biomass energy during the heating season is greater than that during the nonheating season. (4) The resulting backward trajectory indicates that a large portion of the high EBC aerosol concentration sources originate from northern and northwestern China. Our results reveal that the characteristics and sources of EBC in the urban environment of northern China vary widely, suggesting that different measures should be taken to reduce BC aerosol concentrations during heating and nonheating seasons.
Multi-Element Composition of Diatom Chaetoceros spp. from Natural Phytoplankton Assemblages of the Russian Arctic Seas
Authors: Lobus Nikolay V. , Kulikovskiy Maxim S. , Maltsev Yevhen I.
Published: October 2021

Data on the elemental composition of the diatom Chaetoceros spp. from natural phytoplankton communities of Arctic marine ecosystems are presented for the first time. Samples were collected during the 69th cruise (22 August–26 September 2017) of the R/V Akademik Mstislav Keldysh in the Kara, Laptev, and East Siberian Seas. The multi-element composition of the diatom microalgae was studied by ICP-AES and ICP-MS methods. The contents of major (Na, Mg, Al, Si, P, S, K and Ca), trace (Li, Be, B, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, Ga, As, Se, Rb, Sr, Mo, Ag, Cd, Sn, Sb, Cs, Ba, Hg, Tl, Pb, Bi, Th and U) and rare earth (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu) elements varied greatly, which was probably associated with the peculiarities of the functional state and mineral nutrition of phytoplankton in the autumn period. Biogenic silicon was the dominant component of the chemical composition of Chaetoceros spp., averaging 19.10 ± 0.58% of dry weight (DW). Other significant macronutrients were alkaline (Na and K) and alkaline earth (Ca and Mg) metals as well as biogenic (S and P) and essential (Al and Fe) elements. Their total contents varied from 1.26 to 2.72% DW, averaging 2.07 ± 0.43% DW. The Al:Si ratio for natural assemblages of Chaetoceros spp. of the shelf seas of the Arctic Ocean was 5.8 × 10−3. The total concentrations of trace and rare earth elements on average were 654.42 ± 120.07 and 4.14 ± 1.37 μg g−1 DW, respectively. We summarize the scarce data on the average chemical composition of marine and oceanic phytoplankton and discuss the limitations and approaches of such studies. We conclude on the lack of data and the need for further targeted studies on this issue.
Longitudinal Pathogenic Properties and N-Glycosylation Profile of Antibodies from Patients with Pemphigus after Corticosteroid Treatment
Authors: Petit Marie , Walet-Balieu Marie-Laure , Schapman Damien , Golinski Marie-Laure , Burel Carole , Barray Marion , Drouot Laurent , Maho-Vaillant Maud , Hébert Vivien , Boyer Olivier , Bardor Muriel , Joly Pascal , Calbo Sébastien
Published: October 2021

Pemphigus vulgaris is an autoimmune disease that occurs due to pathogenic autoantibodies that recognize the following epidermal adhesion proteins: desmogleins. Systemic corticosteroids usually decrease the titers of anti-desmoglein autoantibodies and improve patients’ conditions. Since modifications of IgG N-glycosylation have been described in some autoimmune diseases, we hypothesized that changes in the pathogenic activity of pemphigus IgG could be related to changes in their N-glycosylation profile. The purpose of this study was to assess, longitudinally, the pathogenicity of pemphigus serum IgG and their N-glycosylation profile during phases of disease activity and clinical remission. The pathogenic activity of serum IgG was measured in vitro on immortalized keratinocytes, by immunofluorescence and dissociation assays, and IgG N-glycans were analyzed by mass spectrometry. We showed (i) a correlation between pemphigus clinical activity and the pathogenicity of serum IgG at baseline and at month 6, while the persistence of the in vitro pathogenic activity of IgG during its evolution, even in patients in clinical remission, seemed to be predictive of relapse; (ii) that modifications of the N-glycan structure were altered the in vitro pathogenicity of patients’ autoantibodies; (iii) that the pathogenic properties of pemphigus IgG did not appear to be related to the disparity in IgG N-glycans during the course of pemphigus.
The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris
Authors: Hsueh Tun-Pin , Lin Wan-Ling , Dalley Jeffrey W. , Tsai Tung-Hu
Published: October 2021

Artemisia capillaris Thunb. (A.capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A.capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A.capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects.
In Vitro Disease Models of the Endocrine Pancreas
Authors: Milojević Marko , Rožanc Jan , Vajda Jernej , Činč Ćurić Laura , Paradiž Eva , Stožer Andraž , Maver Uroš , Vihar Boštjan
Published: October 2021

The ethical constraints and shortcomings of animal models, combined with the demand to study disease pathogenesis under controlled conditions, are giving rise to a new field at the interface of tissue engineering and pathophysiology, which focuses on the development of in vitro models of disease. In vitro models are defined as synthetic experimental systems that contain living human cells and mimic tissue- and organ-level physiology in vitro by taking advantage of recent advances in tissue engineering and microfabrication. This review provides an overview of in vitro models and focuses specifically on in vitro disease models of the endocrine pancreas and diabetes. First, we briefly review the anatomy, physiology, and pathophysiology of the human pancreas, with an emphasis on islets of Langerhans and beta cell dysfunction. We then discuss different types of in vitro models and fundamental elements that should be considered when developing an in vitro disease model. Finally, we review the current state and breakthroughs in the field of pancreatic in vitro models and conclude with some challenges that need to be addressed in the future development of in vitro models.
Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy
Authors: Truzman Tammar , Rochon Elizabeth , Meltzer Jed , Leonard Carol , Bitan Tali
Published: October 2021

Changes in brain connectivity during language therapy were examined among participants with aphasia (PWA), aiming to shed light on neural reorganization in the language network. Four PWA with anomia following left hemisphere stroke and eight healthy controls (HC) participated in the study. Two fMRI scans were administered to all participants with a 3.5-month interval. The fMRI scans included phonological and semantic tasks, each consisting of linguistic and perceptual matching conditions. Between the two fMRI scans, PWA underwent Phonological Components Analysis treatment. Changes in effective connectivity during the treatment were examined within right hemisphere (RH) architecture. The results illustrate that following the treatment, the averaged connectivity of PWA across all perceptual and linguistic conditions in both tasks increased resemblance to HC, reflecting the normalization of neural processes associated with silent object name retrieval. In contrast, connections that were specifically enhanced by the phonological condition in PWA decreased in their resemblance to HC, reflecting emerging compensatory reorganization in RH connectivity to support phonological processing. These findings suggest that both normalization and compensation play a role in neural language reorganization at the chronic stage, occurring simultaneously in the same brain.
Problems and Challenges in the Interactions of Design Teams of Construction Projects: A Bibliometric Study
Authors: Galaz-Delgado Eduardo I. , Herrera Rodrigo F. , Atencio Edison , Muñoz-La Rivera Felipe , Biotto Clarissa N.
Published: October 2021

There is no comprehensive understanding of the problems that may impact the performance of the different actors that participate in the design of construction projects. In the absence of clarity about the problems and challenges that may impact the interactions, it is not possible to propose action plans to optimize the performance of the design teams. Therefore, this study proposes to identify the main problems and challenges in the interactions of design teams in building projects. A mixed review method is used to integrate bibliometric reviews, systematic reviews, and social network analysis to build a complete picture of the reviewed topic while highlighting certain key areas to ensure in-depth research. To achieve the objective of this work, the research was divided into three stages: (1) study of interactions in design teams; (2) identification of problems in design team interactions; and (3) study of problems in design team interactions. Through this study, four current major trends of research were identified: (1) Collaboration and BIM; (2) Design teams in the construction industry; (3) Design management; and (4) Collaborative design methodologies and processes. In addition, the most relevant problems or challenges within design team interactions arise in communication, collaboration, coordination, trust, and role identification.
Pancreatic Cancer Microenvironment and Cellular Composition: Current Understandings and Therapeutic Approaches
Authors: Truong Linh-Huyen , Pauklin Siim
Published: October 2021

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human solid tumors, despite great efforts in improving therapeutics over the past few decades. In PDAC, the distinct characteristic of the tumor microenvironment (TME) is the main barrier for developing effective treatments. PDAC TME is characterized by a dense stroma, cancer-associated fibroblasts, and immune cells populations that crosstalk to the subpopulations of neoplastic cells that include cancer stem cells (CSCs). The heterogeneity in TME is also exhibited in the diversity and dynamics of acellular components, including the Extracellular matrix (ECM), cytokines, growth factors, and secreted ligands to signaling pathways. These contribute to drug resistance, metastasis, and relapse in PDAC. However, clinical trials targeting TME components have often reported unexpected results and still have not benefited patients. The failures in those trials and various efforts to understand the PDAC biology demonstrate the highly heterogeneous and multi-faceted TME compositions and the complexity of their interplay within TME. Hence, further functional and mechanistic insight is needed. In this review, we will present a current understanding of PDAC biology with a focus on the heterogeneity in TME and crosstalk among its components. We also discuss clinical challenges and the arising therapeutic opportunities in PDAC research.
Effect of Peptide Receptor Radionuclide Therapy in Combination with Temozolomide against Tumor Angiogenesis in a Glioblastoma Model
Authors: Lee Sang Hee , Choi Ji Young , Jung Jae Ho , Song In Ho , Park Hyun Soo , Denora Nunzio , Leonetti Francesco , Kim Sang Eun , Lee Byung Chul
Published: October 2021

Cell adhesion receptor integrin αvβ3 is a promising biomarker for developing tumor-angiogenesis targeted theranostics. In this study, we aimed to examine the therapeutic potential of peptide receptor radionuclide therapy (PRRT) with 188Re-IDA-D-[c(RGDfK)]2 (11.1 MBq). The results showed that the tumor volume was significantly decreased by 81% compared with the vehicle-treated group in U87-MG xenografts. The quantitative in vivo anti-angiogenic responses of PRRT were obtained using 99mTc-IDA-D-[c(RGDfK)]2 SPECT and corresponded to the measured tumor volume. PRRT combined with temozolomide (TMZ) resulted in a 93% reduction in tumor volume, which was markedly greater than that of each agent used individually. In addition, histopathological characterization showed that PRRT combined with TMZ was superior to PRRT or TMZ alone, even when TMZ was used at half dose. Overall, our results indicated that integrin-targeted PRRT and TMZ combined therapy might be a new medical tool for the effective treatment of glioblastoma.
Nematostella vectensis, an Emerging Model for Deciphering the Molecular and Cellular Mechanisms Underlying Whole-Body Regeneration
Authors: Röttinger Eric
Published: October 2021

The capacity to regenerate lost or injured body parts is a widespread feature within metazoans and has intrigued scientists for centuries. One of the most extreme types of regeneration is the so-called whole body regenerative capacity, which enables regeneration of fully functional organisms from isolated body parts. While not exclusive to this habitat, whole body regeneration is widespread in aquatic/marine invertebrates. Over the past decade, new whole-body research models have emerged that complement the historical models Hydra and planarians. Among these, the sea anemone Nematostella vectensis has attracted increasing interest in regard to deciphering the cellular and molecular mechanisms underlying the whole-body regeneration process. This manuscript will present an overview of the biological features of this anthozoan cnidarian as well as the available tools and resources that have been developed by the scientific community studying Nematostella. I will further review our current understanding of the cellular and molecular mechanisms underlying whole-body regeneration in this marine organism, with emphasis on how comparing embryonic development and regeneration in the same organism provides insight into regeneration specific elements.
Paper-Based Device for Sweat Chloride Testing Based on the Photochemical Response of Silver Halide Nanocrystals
Authors: Choleva Tatiana G. , Matiaki Christina , Sfakianaki Afroditi , Vlessidis Athanasios G. , Giokas Dimosthenis L.
Published: October 2021

A new method for the determination of chloride anions in sweat is described. The novelty of the method relies on the different photochemical response of silver ions and silver chloride crystals when exposed to UV light. Silver ions undergo an intense colorimetric transition from colorless to dark grey-brown due to the formation of nanosized Ag while AgCl exhibits a less intense color change from white to slightly grey. The analytical signal is obtained as mean grey value of color intensity on the paper surface and is expressed as the absolute difference between the signal of the blank (i.e., in absence of chloride) and the sample (i.e., in the presence of chloride). The method is simple to perform (addition of sample, incubation in the absence of light, irradiation, and offline measurement in a flatbed scanner), does not require any special signal processing steps (the color intensity is directly measured from a constant window on the paper surface without any imager processing) and is performed with minimum sample volume (2 μL). The method operates within a large chloride concentration range (10–140 mM) with good detection limits (2.7 mM chloride), satisfactory recoveries (95.2–108.7%), and reproducibility (<9%). Based on these data the method could serve as a potential tool for the diagnosis of cystic fibrosis through the determination of chloride in human sweat.
Distribution and Role of Oct-1-en-3-ol in Marine Algae
Authors: Jerković Igor , Radman Sanja , Jokić Stela
Published: October 2021

Oct-1-en-3-ol has been studied among oxylipins as a global metabolome that induce the defense of marine algae. The present short review summarized the research of oct-1-en-3-ol as the stress response molecule in marine algae including different aspects: (i) its biosynthesis from fatty acids; (ii) its distribution in marine algae; (iii) a direct effect of oct-1-en-3-ol on microorganisms infecting the thalli; (iv) an indirect communication molecule for alga-alga signaling; and (v) as an inducer that initiates the defense response of algae.
Research Summary on the Processing, Mechanical and Tribological Properties of Aluminium Matrix Composites as Effected by Fly Ash Reinforcement
Authors: Razzaq Alaa Mohammed , Majid Dayang Laila , Basheer Uday M. , Aljibori Hakim S. Sultan
Published: October 2021

Fly ash is the main waste as a result of combustion in coal fired power plants. It represents about 40% of the wastes of coal combustion products (fly ash, boiler ash, flue gas desulphurization gypsum and bottom ash). Currently, coal waste is not fully utilized and waste disposal remains a serious concern despite tremendous global efforts in reducing fossil fuel dependency and shifting to sustainable energy sources. Owing to that, employment of fly ash as reinforcement particles in metallic matrix composites are gaining momentum as part of recycling effort and also as a means to improve the specifications of the materials that are added to it to form composite materials. Many studies have been done on fly ash to study composite materials wear characteristics including the effects of fly ash content, applied load, and sliding velocity. Here, particular attention is given to studies carried out on the influence FA content on physical, mechanical, and the thermal behavior of Aluminium-FA composites. Considerable changes in these properties are seen by fly ash refinement with limited size and weight fraction. The advantage of fly ash addition results in low density of composites materials, improvement of strength, and hardness. It further reduces the thermal expansion coefficient and improve wear resistance.
Calcium Tungstate Doped with Rare Earth Ions Synthesized at Low Temperatures for Photoactive Composite and Anti-Counterfeiting Applications
Authors: Yi Soung-Soo , Jung Jae-Yong
Published: October 2021

A precursor was prepared using a co-precipitation method to synthesize crystalline calcium tungstate. The prepared precursor was dried in an oven at 80 °C for 18 h. The dried powders, prepared without a heat treatment process, were observed in XRD analysis to be a crystalline CaWO4 phase, confirming that the synthesis of crystalline CaWO4 is possible even at low temperature. To use this crystalline CaWO4 as a light emitting material, rare earth ions were added when preparing the precursor. The CaWO4 powders doped with terbium (Tb3+) and europium (Eu3+) ions, respectively, were also observed to be crystalline in XRD analysis. The luminescence of the undoped CaWO4 sample exhibited a wide range of 300~600 nm and blue emission with a central peak of 420 nm. The Tb3+-doped sample showed green light emission at 488, 545, 585, and 620 nm, and the Eu3+-doped sample showed red light emission at 592, 614, 651, and 699 nm. Blue, green, and red CaWO4 powders with various luminescence properties were mixed with glass powder and heat-treated at 600 °C to fabricate a blue luminescent PiG disk. In addition, a flexible green and red light-emitting composite was prepared by mixing it with a silicone-based polymer. An anti-counterfeiting application was prepared by using the phosphor in an ink, which could not be identified with the naked eye but can be identified under UV light.
Mobile Apps to Fight the COVID-19 Crisis
Authors: Tsinaraki Chrisa , Mitton Irena , Minghini Marco , Micheli Marina , Kotsev Alexander , Hernandez Quiros Lorena , Spinelli Fabiano-Antonio , Dalla Benetta Alessandro , Schade Sven
Published: October 2021

The COVID-19 pandemic led to a multi-faceted global crisis, which triggered the diverse and quickly emerging use of old and new digital tools. We have developed a multi-channel approach for the monitoring and analysis of a subset of such tools, the COVID-19 related mobile applications (apps). Our approach builds on the information available in the two most prominent app stores (i.e., Google Play for Android-powered devices and Apple’s App Store for iOS-powered devices), as well as on relevant tweets and digital media outlets. The dataset presented here is one of the outcomes of this approach, uses the content of the app stores and enriches it, providing aggregated information about 837 mobile apps published across the world to fight the COVID-19 crisis. This information includes: (a) information available in the mobile app stores between 20 April 2020 and 2 August 2020; (b) complementary information obtained from manual analysis performed until mid-September 2020; and (c) status information about app availability on 28 February 2021, when we last collected data from the mobile app stores. We highlight our findings with a series of descriptives, which depict both the activities in the app stores and the qualitative information that was revealed by the manual analysis.
New Treatment Strategy Using Repetitive Transcranial Magnetic Stimulation for Post-Stroke Aphasia
Authors: Hara Takatoshi , Abo Masahiro
Published: October 2021

Repetitive transcranial magnetic stimulation (rTMS) for post-stroke aphasia (PSA) has been suggested to promote improvement of language function when used in combination with rehabilitation. However, many challenges remain. In some reports examined by category of language function, only naming has good evidence of improvement, and the improvement effect on other language modalities is low. Therefore, it is necessary to establish methods that contribute to the improvement of language functions other than naming. Therapeutic methods for PSA based on the mechanism of rTMS are mainly inhibitory stimulation methods for language homologous areas. However, the mechanisms of these methods are controversial when inferred from the process of recovery of language function. Low-frequency rTMS applied to the right hemisphere has been shown to be effective in the chronic phase of PSA, but recent studies of the recovery process of language function indicate that this method is unclear. Therefore, it has been suggested that evaluating brain activity using neuroimaging contributes to confirming the effect of rTMS on PSA and the elucidation of the mechanism of functional improvement. In addition, neuroimaging-based stimulation methods (imaging-based rTMS) may lead to further improvements in language function. Few studies have examined neuroimaging and imaging-based rTMS in PSA, and further research is required. In addition, the stimulation site and stimulation parameters of rTMS are likely to depend on the time from onset to intervention. However, there are no reports of studies in patients between 90 and 180 days after onset. Therefore, research during this period is required. New stimulation methods, such as multiple target methods and the latest neuroimaging methods, may contribute to the establishment of new knowledge and new treatment methods in this field.
Analysis of Brain MRI Images Using Improved CornerNet Approach
Authors: Nawaz Marriam , Nazir Tahira , Masood Momina , Mehmood Awais , Mahum Rabbia , Khan Muhammad Attique , Kadry Seifedine , Thinnukool Orawit
Published: October 2021

The brain tumor is a deadly disease that is caused by the abnormal growth of brain cells, which affects the human blood cells and nerves. Timely and precise detection of brain tumors is an important task to avoid complex and painful treatment procedures, as it can assist doctors in surgical planning. Manual brain tumor detection is a time-consuming activity and highly dependent on the availability of area experts. Therefore, it is a need of the hour to design accurate automated systems for the detection and classification of various types of brain tumors. However, the exact localization and categorization of brain tumors is a challenging job due to extensive variations in their size, position, and structure. To deal with the challenges, we have presented a novel approach, namely, DenseNet-41-based CornerNet framework. The proposed solution comprises three steps. Initially, we develop annotations to locate the exact region of interest. In the second step, a custom CornerNet with DenseNet-41 as a base network is introduced to extract the deep features from the suspected samples. In the last step, the one-stage detector CornerNet is employed to locate and classify several brain tumors. To evaluate the proposed method, we have utilized two databases, namely, the Figshare and Brain MRI datasets, and attained an average accuracy of 98.8% and 98.5%, respectively. Both qualitative and quantitative analysis show that our approach is more proficient and consistent with detecting and classifying various types of brain tumors than other latest techniques.
High-Power Vacuum Electronic Devices from Microwave to THz Band: Way Forward
Authors: Mikhail Glyavin
Published: October 2021

It is generally accepted that the 20th century was the age of electronics [...]
Transient Stability Enhancement of a Grid-Connected Large-Scale PV System Using Fuzzy Logic Controller
Authors: Hazari Md. Rifat , Jahan Effat , Mannan Mohammad Abdul , Das Narottam
Published: October 2021

This paper presents a new intelligent control strategy to augment the low-voltage ride-through (LVRT) potential of photovoltaic (PV) plants, and the transient stability of a complete grid system. Modern grid codes demand that a PV plant should be connected to the main power system during network disturbance, providing voltage support. Therefore, in this paper, a novel fuzzy logic controller (FLC) using the controlled cascaded strategy is proposed for the grid side converter (GSC) of a PV plant to guarantee voltage recovery. The proposed FLC offers variable gains based upon the system requirements, which can inject a useful amount of reactive power after a severe network disturbance. Therefore, the terminal voltage dip will be low, restoring its pre-fault value and resuming its operation quickly. To make it realistic, the PV system is linked to the well-known IEEE nine bus system. Comparative analysis is shown—using power system computer-aided design/electromagnetic transients including DC (PSCAD/EMTDC) software—between the conventional proportional–integral (PI) controller-based cascaded strategy and the proposed control strategy to authenticate the usefulness of the proposed strategy. The comparative simulation results indicate that the transient stability and the LVRT capability of a grid-tied PV system can be augmented against severe fault using the proposed FLC-based cascaded GSC controller.
RF Pogo-Pin Probe Card Design Aimed at Automated Millimeter-Wave Multi-Port Integrated-Circuit Testing
Authors: Lee K. M. , Oh J. H. , Kim M. S. , Kim T. S. , Kim M.
Published: October 2021

A prototype RF probe card is assembled to test the feasibility of Pogo-pins as robust probe tips for the automized testing of multiple-port millimeter-wave circuits. A custom-made ceramic housing machined from a low-loss dielectric holds an array of 157 Pogo-pins, each with 2.9 mm-length in fixed positions. The ceramic housing is then mounted onto a probe-card PCB for power-loss measurements on two signal-ground Pogo-pin connections arbitrarily selected from the array. The probing results on a test circuit with a simple thru-line indicate a successful power transfer with a small insertion loss of less than 0.5 dB per single Pogo-pin connection up to 25 GHz. A new probe card design using shorter Pogo-pins is being prepared to extend the operation frequency to beyond 40 GHz.
Assessing Predictive Factors of COVID-19 Outcomes: A Retrospective Cohort Study in the Metropolitan Region of São Paulo (Brazil)
Authors: Amato Juliana Neide , Castelo Paula Midori , Cirino Ferla Maria Simas Bastos , Meyer Guilherme , Pereira Luciano José , Sartori Luís Cláudio , Aderaldo Natália Simões , Silva Fernando Capela e
Published: October 2021

Background and Objectives: The aim of this retrospective cohort study was to search individual, sociodemographic and environmental predictors of COVID-19 outcomes. Materials and Methods: A convenience sample of 1036 COVID-19 confirmed patients (3–99 years, mean 59 years; 482 females) who sought treatment at the emergency units of the public health system of Diadema (Brazil; March–October 2020) was included. Primary data were collected from medical records: sex, age, occupation/education, onset of symptoms, presence of chronic diseases/treatment and outcome (death and non-death). Secondary socioeconomic and environmental data were provided by the Department of Health. Results: The mean time spent between COVID-19 symptom onset and admission to the health system was 7.4 days. Principal component analysis summarized secondary sociodemographic data, and a Poisson regression model showed that the time between symptom onset and health system admission was higher for younger people and those from the least advantaged regions (availability of electricity, a sewage network, a water supply and garbage collection). A multiple logistic regression model showed an association of age (OR = 1.08; 1.05–1.1), diabetes (OR = 1.9; 1.1–3.4) and obesity (OR = 2.9; 1.1–7.6) with death outcome, while hypertension and sex showed no significant association. Conclusion: The identification of vulnerable groups may help the development of health strategies for the prevention and treatment of COVID-19.
Remote Sensing Image Target Detection: Improvement of the YOLOv3 Model with Auxiliary Networks
Authors: Qu Zhenfang , Zhu Fuzhen , Qi Chengxiao
Published: October 2021

Remote sensing image target detection is widely used for both civil and military purposes. However, two factors need to be considered for remote sensing image target detection: real-time and accuracy for detecting targets that occupy few pixels. Considering the two above issues, the main research objective of this paper is to improve the performance of the YOLO algorithm in remote sensing image target detection. The reason is that the YOLO models can guarantee both detection speed and accuracy. More specifically, the YOLOv3 model with an auxiliary network is further improved in this paper. Our model improvement consists of four main components. Firstly, an image blocking module is used to feed fixed size images to the YOLOv3 network; secondly, to speed up the training of YOLOv3, DIoU is used, which can speed up the convergence and increase the training speed; thirdly, the Convolutional Block Attention Module (CBAM) is used to connect the auxiliary network to the backbone network, making it easier for the network to notice specific features so that some key information is not easily lost during the training of the network; and finally, the adaptive feature fusion (ASFF) method is applied to our network model with the aim of improving the detection speed by reducing the inference overhead. The experiments on the DOTA dataset were conducted to validate the effectiveness of our model on the DOTA dataset. Our model can achieve satisfactory detection performance on remote sensing images, and our model performs significantly better than the unimproved YOLOv3 model with an auxiliary network. The experimental results show that the mAP of the optimised network model is 5.36% higher than that of the original YOLOv3 model with the auxiliary network, and the detection frame rate was also increased by 3.07 FPS.
Improving the nutritional value of sugar cookies
Authors: Bobozhonova G.A. , Churbakov N.O.
Published: October 2021

The use of high-protein flour from sunflower meal pellets, vitamin and mineral mixture “Kolos-Forte” and liquid vegetable oil in the recipe composition of sugar cookies is proposed in order to increase their nutritional value. It has been found that when a single serving (100 g) of the developed sugar cookies is consumed, 16% of the daily physiological protein requirement is satisfied. The range of flour confectionery products of increased nutritional value has been expanded.
Short-term therapies (CBT and EMDR) for anxiety reactions and states in healthcare professionals
Authors: Shturmin Filipp Sergeevich , Gardanova Zhanna Robertovna
Published: October 2021

The relevance of the topic under consideration lies in the need to analyze the effectiveness of short-term methods of psychotherapy to provide prompt psychotherapeutic assistance in dealing with anxiety states and reactions in employees of medical institutions, including during the period of increased stress associated with the spread of the coronavirus infection. The study was conducted on a sample of 60 medical professionals. The experimental group of 30 people was divided into two groups of 15 people (group A and group B) and a control group of 30 people. According to the results of the study, the positive effect of group methods of short-term psychotherapy on reducing the level of anxiety states and reactions in medical professionals was revealed. It was also found that the psychocorrective influence on medical professionals by means of techniques of eye movement desensitization and reprocessing was more effective than by the techniques of cognitive behavioral therapy.
Anti-NMDA receptor encephalitis in the practice of a psychiatrist on the example of a clinical case
Authors: Gareeva Kristina S. , Valinurov Rinat G. , Khritinin Dmitriy F.
Published: October 2021

Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a treatable autoimmune disease of the central nervous system (CNS) with prominent neurologic and psychiatric features at disease onset. Anti-NMDAR encephalitis can occur in all ages. The disorder predominantly affects children and young adults, occurs with or without tumour association, and can relapse. The presence of a tumour (usually an ovarian teratoma) is dependent on age, sex, and ethnicity, being more frequent in women older than 18 years. Primarily presents in the form of mental disorders, seizures, and involuntary movement, and is often accompanied by sleep disorders and prominent speech difficulties. Anti-NMDAR encephalitis in children may present differently than in adults. Children are more likely to have abnormal movements (chorea, incoordination) early in the disease course and also may have atypical motor symptoms such as ataxia or hemiparesis. Children more often have seizures than adults. The classic symptoms of psychosis seen in adults are less common, but behavioral regression is frequently noted. The proper diagnosis and management of autoimmune encephalitis requires a multidisciplinary treatment approach. Ancillary testing with MRI, EEG, lumbar puncture and immunological assessment of cerebrospinal fluid and serum may further support a diagnosis of encephalitis and potentially suggest particular causes. Early immune-modulatory treatment can alleviate the severity of the disease and improve the cure rate. Further study of anti-NMDAR antibody and its related encephalitis would give essential clues for the research of schizophrenia, catatonia, and atypical psychosis.
Sodium fluorescein and indocyanine green in neuro-oncology and surgery of brain arteriovenous malformations. Review
Authors: Yuryevich Dmitriev Alexander , Dashyan Vladimir Grigoryevich
Published: October 2021

In this article we generalized results of sodium fluorescein and indocyanine green usage in removing of brain tumors and arteriovenous malformations. Basic principles of fluorescence, it’s sensitivity and specificity are thoroughly described. Drug’s dosages, their ways and exposition of administration are indicated. Special attention is payed at fluorophores’ use in removing of various brain lesions.Concerning fluorescence with indocyanine we reviewed «second window» effect, expanding its usage in neurooncology. In conclusion we described other perspective methods of fluorescence that are being actively researched but have not been implemented in clinical practice yet.
Impact of coronavirus infection on children and adolescents with mental disorders
Authors: Filippova Natal’a Valer’evna , Barylnik Yulia Borisovna , Karabanova Ekaterina Vyacheslavovna , Egorova Svetlana Olegovna
Published: October 2021

The article presents the results of the study of changes in the frequency of hospitalizations and the nosological composition of diagnoses of children and adolescents hospitalized in the Regional Clinical Psychiatric Hospital of Hagia Sophia during the period of self-isolation from March to May 2020, compared to the same period in 2019. The clinical cases that demonstrate the development of a new-onset psychotic disorder under the influence of stress factors provoked by the COVID-19 pandemic are presented.

English version of the article on pp. 730-735 is available at URL: https://panor.ru/articles/impact-of-coronavirus-infection-on-children-and-adolescents-with-mental-disorders/70278.html
Correlation of cognitive disorders and catecholamine excretion in anorexia nervosa
Authors: Marina Stanislavovna Artemieva Marina Stanislavovna Artemieva , Tsygankov Boris Dmitrievich , Suleymanov Roman Aleksandrovich , Danilin Ivan Evgenievich , Arseniev Aleksandr Romanovich , Lazukova Anastasiya Gennadievna
Published: October 2021

The article presents the analysis of correlation and dynamics of clinical and psychophysiological characteristics of the long-term effects of long-lasting abstinence from food on the example of 500 women with anorexia nervosa (AN), who applied for help to the Department of Psychiatry and Medical Psychology, FSAEI HE Peoples’ Friendship University of Russia in 1989-2017. The adverse effects of prolonged abstinence from food are shown; the indicators of catecholamine excretion (dopamine, adrenaline, norepinephrine), encephalography data, mental performance and memory of those examined at various stages of AN weight loss and gain were studied. The difference in the excretion of catecholamines in AN and psychogenic vomiting, which can be used for differential diagnosis, was demonstrated.
Lateral ventricular stenting as a method of preventing trapped temporal horn following resection of lateral ventricular trigone tumor. Case report and review of literature
Authors: Maryashev S. A. , Ishkinin R. E. , Pitskhelauri D. I. , Chmutin CE. G.
Published: October 2021

Resection of lateral ventricular trigone tumor can lead the development of specific complication like a trapped temporal horn. Secretion of cerebrospinal fluid from the choroid plexus in closed space leads to progressive enlargement of the temporal horn. The enlargement of the temporal horn leads to lateral transtentorial herniation with brain steam compression, which manifested by disorders of consciousness, hemiparesis, memory impairment and loss of visual fields. The proposed stenting technique allows to prevent the development of extended temporal horn and excludes the requirement its treatment in the long-term period. Over the past year, intraoperative stenting have been performed in five cases. In the long-term period none of the patients have had trapped temporal horn. There was no case of stent dysfunction.The article presents a clinical case of ventricular stenting following resection of lateral ventricular trigone tumor.
Digitalization of national health care
Authors: Ustinovich Elena Stepanovna
Published: October 2021

The purpose of this article is to study the eff ectiveness of using digitalization in national health care. The article outlines the main advantages of using digital technologies in healthcare. The article also shows which areas of digitalization of healthcare are used in the Russian Federation. In addition, it is described that medical centers should carry out remote monitoring of patients in order to prevent critical conditions. This article outlines the benefi ts of digitalizing healthcare and its main directions. Today, the transition of Russian healthcare to an innovative digital platform is an urgent task. Digitalization of healthcare is a prerequisite for the development of this industry. In addition, such a process serves as a major factor in economic and social progress. Digital technologies are one of the priorities for the development of the healthcare sector. Every year this area is increasing by a quarter. The digitalization process will help provide a breakthrough in the availability and quality of services without increasing healthcare costs. Several information projects have been implemented in the Russian Federation over the past few years.
Monitoring of human capital research issues in ethnosocial processes and social trends
Authors: Sodirjonov M. M.
Published: October 2021

The article analyzes the «active» approach to the description of human potential and the system of readiness of individuals and communities to perform social roles and functions, such as needs and abilities. While human potential is based on» abilities «and abilities are based on» needs», the category of capital is embodied as» choice», that is, the mechanism that manages needs and abilities. Also, when interpreting the socio-economic aspects of human and collective characteristics, the «purchase» function (material wealth, knowledge, social relations, infl uence) is currently used, which is the basis of their capital needs, and since economic resources, i.e. real estate, stocks, business aspects, etc., have been studied using sociological classifi cations that embody current trends. The potential unity and integrity of the chosen society or state is formed primarily by its ethnic and national-cultural composition, and the meaning of life is provided. Another important component — the need to maintain professionalism and contributing to the demographic jump, is the «labor» factor. Work is an activity in which individuals and communities create products and services of individual, social significance. In sociology, the sectoral component of human capital is provided by the norms, rules, trust relationships, mutual obligations, responsibility, and solidarity that govern social relations between people. These centers can be called collective unifying forces of human potential and capabilities. In the context of Uzbekistan, this is done by the mahalla system, which is recognized as a self-governing body. The main objectives of the development of the network component of human capital are to maintain and strengthen direct links with the social environment on a positive basis, reduce or eliminate negative aspects, and achieve systematic development of the potential of individuals and communities. Socio-cultural and economic-political changes in society have a unique impact on each person and are reflected in public opinion. Needs and interests lead to the formation of a paternalistic attitude of the state to public opinion, and it largely justifies itself for the implementation of social capital.
Motivarion — is one of the most important functions of management
Authors: Makarova Evgenia Vladimirova
Published: October 2021

This article provides information about one of the main functions of management. The answer to the most important question was received: «Why do people need motivation?» The main theoretical material on this topic is considered, which can help students and teachers become better acquainted with this problem. Also the concepts of motive and incentive are considered, which are directly related to motivation. Various points of view of scientists on this problem are presented. Different aspects of motivation are considered, which have strong influence and impact on the work of the entire production or the enterprise. The conclusion showed that this topic would always be relevant. A person should strive to achieve his goals and desires. The success of the whole team or the whole enterprise will always depend on the presence of motivation. Leaders have a responsibility to incentivize their employees if they are interested in the prosperity and development of their business.
Artificial Intelligence in Public Administration and Business: Benefits for Society and Social Policy
Authors: Ustinovich Elena Stepanovna
Published: October 2021

Artificial intelligence technologies are used in various spheres of human life. One of the promising areas of AI application is the sphere of public administration. Public authorities are introducing communication and information technologies to create new intelligent systems and develop new strategies to prevent risks in public administration. In December 2020, the President of the Russian Federation V. V. Putin signed a decree on the Strategy for the Development of Artificial Intelligence in the Russian Federation. This article presents the directions of the development of artificial intelligence in the Russian Federation, the forecast of trends and transformations in the spheres of public life due to the use of artificial intelligence.