bluuebunny/crossref_metadata_2025 huggingface dataset:
Prosodic realization and interpretation of English imperatives
Authors: McClay Elise , Keough Megan , Babel Molly , Matthewson Lisa
Published: August 2023

Imperative clauses can communicate a number of speech acts, and differences in intonation have been argued to prompt different interpretations. So far, however, limited phonetic evidence has been presented for such proposals. The focus in the current work is on maximally strong imperatives (commands) and weaker imperatives (mainly involving advice) in English. We report on a series of phonetic experiments intended to address whether listeners reliably associate stronger and weaker imperatives with idealized intonation (Experiment 1) and whether speakers produce these two types of imperatives differently (Experiment 2). Individual variability in our production data led us to test whether listeners can map the variable pronunciation patterns found in Experiment 2 to stronger and weaker imperatives (Experiment 3), as they did with the idealized pronunciations in Experiment 1. Despite substantial cross-talker intonation variation, listeners’ stronger/weaker imperative recognition performance paralleled accuracy with the idealized productions. Analysis of the whole utterances indicates that speech rate and global pitch setting work along with the final intonation contour to signal semantic meaning in English imperatives. These results suggest that the mapping between meaning and form is complex and involves redundancy.
Bambúes nativos en la construcción de viviendas rurales: Bajareque en el México prehispánico y siglo XX
Authors: Ruiz-Sanchez Eduardo , García-Martínez Miguel Ángel , Heredia Espinoza Verenice Y.
Published: August 2023

Antecedentes: El bajareque es una técnica de construcción en la que se utiliza un tejido hecho con bambú, cañas, varas, mimbres, agregados con diversos compuestos de tierra local, material vegetal y agua (lodo). En México, existe evidencia arqueológica y actual del uso del bajareque en la construcción de viviendas rurales. En el sitio arqueológico de Los Guachimontones, se ha documentado el uso del bajareque con una antigüedad de 2,400 a 1,500 años, Sin embargo, se desconoce la especie de bambú utilizada.

Preguntas y/o Hipótesis: 1) ¿Cuáles especies de bambú de México se han utilizado en la construcción de viviendas rurales con la técnica del bajareque? 2) ¿Cuál especie de bambú probablemente se utilizó en la construcción de viviendas con la técnica del bajareque en la zona arqueológica de Los Guachimontones, Jalisco?

Resultados: Nuestros resultados indican el uso de cinco especies de bambú (Guadua amplexifolia, G. paniculata, G. velutina, Otatea acuminata y O. fimbriata) en la construcción del bajareque. Es probable que la especie utilizada en la construcción de viviendas y estructuras cívico-ceremoniales en la zona arqueológica de Los Guachimontones sea Otatea acuminata.

Conclusiones: En este estudio, evidenciamos que en México se han utilizado cinco especies de bambú en la construcción del bajareque. De estas, tres pertenecen al género Guadua y dos al género Otatea. Es muy probable que en Los Guachimontones se haya utilizado Otatea acuminata en la construcción de sus viviendas con la técnica del bajareque.
Smart Technologies. SmartTech-IC 2022: Third International Conference on Smart Technologies, Systems and Applications
Authors: Narváez E. Fabián
Published: August 2023

La Universidad Politécnica Salesiana ha estado promoviendo la investigación científica proporcionando financiamiento para el desarrollo y ejecución de propuestas en diversas áreas de investigación. En la Sede Cuenca, se han formado grupos multidisciplinarios para llevar a cabo estas propuestas de investigación. Aunque estos indicadores demuestran resultados favorables en la implementación de una cultura de investigación sólida, todavía se informan proyectos que, debido a varios factores, no logran publicar sus resultados en revistas indexadas. Entre estos factores se encuentran los altos costos de movilidad de los investigadores para presentar sus trabajos en eventos indexados, así como la falta de implementación de criterios adecuados de cienciometría. Esto ha impedido que, en muchos casos, investigaciones con resultados sobresalientes no sean comunicadas a la comunidad científica internacional, lo que no contribuye al aumento de la productividad académica institucional. Además, en algunos casos, se publican trabajos en revistas sin una indexación que contribuya a los indicadores institucionales (Castillo y Powell, 2019) (Guerrero-Casado, 2017).
Geomorphological deformation examples induced by the February 06, 2023, Pazarcık earthquake (Kahramanmaraş, Türkiye)
Authors: TUROGLU Hüseyin , SARIGÜL Osman
Published: August 2023

The left-laterally strike-slip Pazarcık fault is one of the East Anatolian Fault Zone (EAFZ) segments. On February 6, 2023, the ±85 km long Pazarcık fault generated a highly destructive Mw=7.7 earthquake. This study aims to explain the geomorphological deformations caused by the February 6, 2023, Pazarcık earthquake with typical examples. The surface rupture of the earthquake between Türkoğlu and Gölbaşı was followed precisely, and the changes in the earth's surface due to the left lateral strike-slip were determined, measured, and recorded. A DJI Phantom 4 and a DJI Mini Drone were used for aerial measurements and recordings during the fieldwork. Garmin e-Trex 10 handheld GPS and tape measure were used for terrestrial measurements.
During the field studies, the surface rupture of the earthquake was investigated from a geomorphological perspective and mapped by taking location data. It was determined by the measurements that the left lateral offset distances in the surface fracture vary between 4.0-6.5m. One of the geomorphological deformations of the February 6, 2023 earthquake is transpressional ridges and/or transtensional depressions. Transpressional shortening and/or transtensional extension deformations due to a single surface rupture are the natural consequences of the curvilinear slip plane of the left-laterally strike-slip Pazarcık fault. Liquefaction samples with different characteristics were observed in the Sakarkaya alluvial fill area within the Gölbaşı depression. Rockfalls occurred on sandstone, mudstone, and limestone rock slopes weakened by the discontinuity due to the density of cracks outcropping in the valley where the surface rupture passes in the Kartal, Sakarkaya section. During field studies, slides and spreading were also observed. Typical examples of slide occurred on the unconsolidated fill ground on the south coast of Gölbaşı Lake with a slight slope towards the lake as a result of the vibration effect of the earthquake. In addition, the vibration effect of the earthquake caused lateral spreading deformations in the artificial fillings of road and road junction structures.
Morphometric Characteristics of Freshwater Crayfish (Pontastacus leptodactylus Eschscholtz, 1823) Caught in Sapanca Lake, Türkiye
Authors: BALTACI Muhammed Ali , AYDIN Hamdi , SEYHUN Nadide , DENİZ Tomris
Published: August 2023

This is the first study providing information on some morphometric parameters for Pontastacus leptodactylus from Sapanca Lake (Sakarya), Türkiye. This study was conducted from June - 2016 to October - 2017 and a total of 264 crayfish were caught, being 146 females and 118 males. The results revealed that the average total length for the population was 91.89±15.68 mm (TL±SD) (94.75±15.91 mm for females, 88.36±14.72 mm for males), and the average total weight for the total population was 27.27±16.84 g (TW±SD) (29.02±17.54 g for females, 25.09±15.74g for males). The sex ratio was computed as 1.24:1 (female to male). A strong positive statistical relationship was determined between the total length and total weight of females, males, and both sexes (r2: 0.90 – 0.95). This statistically strong relationship was also valid between other body parts, such as carapace length, width, and weight. The regression analyses for total length-total weight relationships also revealed that the whole population exhibited positive allometric growth (b=3.186) regardless of sex, and the condition factor for all sex groups was computed to be over 3 (K=3.23±0.60 SE).
MicroRNAs expression profile in chemotherapy-induced cardiotoxicity in NSCLC using a co-culture model
Authors: Romitan Mihai , Zanoaga Oana , Budisan Liviuta , Jurj Ancuta , Raduly Lajos , Pop Laura , Ciocan Cristina , Pirlog Radu , Braicu Cornelia , Ciuleanu Tudor Eliade , Berindan-Neagoe Ioana
Published: August 2023

Clinical application of chemotherapy in lung cancer is constrained by side effects, notably cardiotoxicity, the mechanisms of which remain elusive. This study assessed the potential of specific miRNAs as biomarkers for chemotherapy-induced cardiotoxicity in lung cancer. We employed two lung adenocarcinoma cell lines (Calu6 and H1792) and ventricular normal human cardiac fibroblasts (NHCF-V) in single and co-culture experiments. Functional tests were conducted using 100 µM carboplatin and 1µM vinorelbine doses. The effects of carboplatin and vinorelbine, both individually and in combination, were evaluated at cellular and molecular levels 48h post-therapy for both mono- and co-cultures. miR-205-5p, miR-21-5p, and miR-30a-5p, modulated by anticancer treatments and influencing cardiotoxicity, were analyzed. Vinorelbine and carboplatin treatment promoted apoptosis and autophagy in lung cancer cells and cardiac fibroblasts more than in controls. Western blot analyses revealed BCL2 and p53 protein upregulation. Using qRT-PCR, we investigated the expression dynamics of miR-21-5p, miR-30c-5p, and miR-205-5p in co-cultured cardiomyocytes and lung cancer cells, revealing altered miRNA patterns from vinorelbine and carboplatin treatment. Our findings underscore the intricate relationship between chemotherapy, miRNA regulation, and cardiotoxicity, highlighting the importance of cardiac health in lung cancer treatment decisions.
ВВЕДЕНИЕ В КОНЦЕПТ ОБЩЕЙ ТЕОРИИ АВТОРСТВА
Authors: ФЕДОТОВ Михаил Александрович
Published: August 2023

В статье обоснована возможность, целесообразность и актуальность разработки концепта общей теории авторства как метатеории современного права интеллектуальной собственности. Проанализированы — в целях выявления противоречий и лакун — основные положения существующего концепта права интеллектуальной собственности. Обоснована безосновательность приравнивания средств индивидуализации к результатам интеллектуальной деятельности, выявлены недостатки в действующем законодательстве об интеллектуальной собственности. Исследовано соотношение понятий «интеллектуальная собственность», «права интеллектуальной собственности», «интеллектуальные права».

Концепт общей теории авторства ставит в центр всей экосистемы интеллектуальной собственности именно автора — субъекта права, творца, а не результат его интеллектуальной деятельности или средство индивидуализации, то есть объект права, как это фактически делает концепт права интеллектуальной собственности. Смена «точки отсчета» неминуемо меняет всю систему логических связей внутри данной сферы, формируя несколько иную «картину интеллектуального мира».

Предлагаемый подход позволяет сформулировать основные понятия общей теории авторства, а именно «автор» и «объект интеллектуальной собственности», а также производные от них понятия, проанализировать основные свойства объектов интеллектуальной собственности, к числу которых относятся нематериальность, гетерогенность, человекоцентричность, креативность, герменевтичность.

Существующие системы правовой охраны объектов интеллектуальной собственности в неявной форме предполагают существование помимо автора еще одного субъекта, без которого не может состояться объект интеллектуальной собственности как объект «для других», — того, кто признает техническое решение — изобретением, упаковку — промышленным образцом, а текст, изображение или трехмерный предмет — произведением науки, литературы или искусства. В случае с объектами регистрационной системы таким субъектом выступает патентное ведомство, в «созидательской» системе — пользователь, потребитель. В статье обосновывается тезис о «соавторстве» пользователя в создании объекта интеллектуальной собственности как объекта «для других».
Neurofilament light protein as a cerebrospinal fluid marker after whiplash trauma
Authors: Olof Bunketorp , Malin Lindh , Fani Pujol-Calderón , Lars Rosengren , Gudrun Silverbåge Carlsson , Henrik Zetterberg
Published: August 2023

The purpose was to investigate if a whiplash trauma may cause an increased concentration of the Neurofilament Light (NFL) protein, and if so; is this related to the injury severity and the radiological findings? Adult car occupants, with neck problems after rear-end collisions, were investigated in a study on Whiplash-Associated Disorders (WAD) in 1997-2001. The study protocol included a neurological examination, plain radiography and MRT of the cervical spine, and a lumbar puncture for Cerebrospinal Fluid (CSF) within six weeks after the accident. Similar CSF samples were also taken three and twelve months later. All CSF samples were analyzed for NFL. Of 52 subjects who entered the study, 43 completed it. The WAD grade was I in two of the 43 cases, II in 13, and III in 28. No one had radiological signs, indicating injuries to the cervical spine or spinal cord. Six subjects showed an increased NFL concentration at the primary examination. This was judged to be caused by whiplash trauma in three of them (7%). There was no relation between an increased NFL concentration and the number of pathological changes on plain radiographs or MRT. Neither was there a relation between the NFL concentration and the WAD grade. An increased NFL concentration can be found in some WAD patients. It might be difficult to relate such an increase to clinical or radiological findings. Further studies should investigate NFL as a marker for injuries to the central nervous system in whiplash trauma, including minimal traumatic brain injuries.
Security and privacy in federated learning: A survey
Authors: Dasaradharami Reddy Kandati , S Anusha
Published: August 2023

Federated Learning (FL) allows multiple nodes without actually sharing data with other confidential nodes to retrain a common model. This is particularly relevant in healthcare applications, where data such as medical records are private and confidential. Although federated learning avoids the exchange of actual data, it still remains possible to fight protection on parameter values revealed in the training process or on a generated Machine Learning (ML) model. This study examines FL’s privacy and security concerns and deals with several issues related to privacy protection and safety when developing FL systems. In addition, we have detailed simulation results to illustrate the problems under discussion and potential solutions.
MAKASLI BİR PLATFORM İÇİN YÜKSELME SÜRESİ VE HİDROLİK SİLİNDİR KUVVETİNE ETKİ EDEN TASARIM PARAMETRELERİNİN İNCELENMESİ
Authors: ESER Sezgin , TELLİ ÇETİN Sevda
Published: August 2023

Makaslı platformlar sahip oldukları basit mekanik yapısı ve üretim kolaylığı sebebiyle endüstride yaygın olarak kullanılmaktadır. Platform için gerek duyulan hidrolik kuvvet ve platformun yükselme süresi, tasarımda önemli faktörler arasında yer almaktadır. Bu çalışmada, platformun uzuv boyu, hidrolik silindirin mafsal konumları ve hidrolik hızı değişken parametreler olarak seçilmiştir. Parametreler için öngörülen farklı değerlerin platformun yükselme süresine ve platformda ihtiyaç duyulan hidrolik kuvvetine etkileri incelenmiştir. Ayrıca, parametre seçimlerinde hidrolik silindirin maksimum strok değeri bir tasarım sınırı olarak dikkate alınmıştır. Hidrolik kuvvet ifadesi hem Virtüel İşler Prensibi (VİP) hem de Virtüel Güçler Prensibi (VGP) ile elde edilerek statik ve dinamik hesaplar arasında oluşan farklar belirlenmiştir. Simülasyonlar sonucunda, farklı tasarım ölçüleri ve hidrolik hızları ile elde edilen sonuçlar karşılaştırılarak yükselme süresini ve hidrolik kuvveti minimize etmek için uygun geometri belirlenmiştir.
DIMPLE library generation and assembly protocol v2
Authors: Macdonald Christian
Published: August 2023

This is a protocol for generating and QCing mutagenic libraries using the DIMPLE protocol. This version is updated to include expanded descriptions of QC and to clarify certain steps.
Liposome binding v1
Authors: Wang Xinbo
Published: August 2023

This protocol details methods for LRRK2-liposome binding experiments analyzed by co-sedimentation or confocal fluorescence microscopy, respectively.
RS17817449 FTO gene variation associated with familial disease burden rather than individual risk for breast cancer
Authors: Hasanbegović Berisa , Sarić Medić Belmina , Sokolović Emir , Tomić Nikolina , Pojskić Lejla
Published: August 2023

Introduction: Breast cancer (BC) is the most common malignancy in the female population globally. Obesity is associated with an increased risk of postmenopausal BC, BC recurrence, and mortality. Fat mass and obesity-associated (FTO) gene polymorphisms have attracted the most attention due to several single-nucleotide polymorphisms (SNPs) that may have an impact on obesity and different types of cancer. The primary goal of our work was to assess the association of the SNP rs17817449 FTO, physical status/metabolic changes, and dietary habits with the occurrence of BC.
Methods: We conducted research as a population-genetic study including 93 women with a diagnosis of BC during their lifetime. Genomic DNA was extracted from the swabs of the buccal mucosa. Genotyping was achieved by polymerase chain reaction-restriction fragment length polymorphism. The IBM SPSS Statistics program v. 23.0 was used for statistical analysis. All values of p < 0.05 were considered statistically significant.
Results: The risk genotype of the FTO gene (rs17817449) GG was detected in 16 subjects (17.2%), the heterozygous TG in 46 subjects (49.5%), while the normal genotype TT was recorded in 29 subjects (31.2%). We found no statistically significant difference in the body mass index values of the three genotype groups, p = 0.72, χ2 = 2.1 and no significant relationship between the allelic or genotypic frequencies of the rs17817449 FTO gene polymorphism and other variables examined in our study. Analysis of the distribution of hereditary diseases in the family according to the molecular subtype of BC showed statistically significant p-values, p = 0.02.
Conclusion: While previous research has suggested a potential link between FTO gene polymorphism, obesity, and BC, our study did not find a statistically significant association between the aforementioned variables. Future studies with a larger number of subjects in different populations should confirm the role of the FTO genotype in the risk of BC.
Design of Solar Still Using Phase Change Material as Storage Medium with an Enhancement of Efficiency of Water Purification
Authors: Aditya R. Wankhade, Ashish R. Pawar Vikaskumar K Mehtre, Mahesh P Kumbhare,
Published: August 2023

Fresh water is becoming scarce with time, leading to severe water crisis in many parts of the world. Among the various methods of purification of water solar distillation is more prominent. Solar distillation has the inherent advantage of low energy consumption. Moreover it is simpler and more economical than other methods.
Precision low-dose brachytherapy of prostate cancer under PSMA-receptor molecular visualization
Authors: Sviridov Pavel V. , Rumiantsev Pavel O. , Degtyarev Mikhail V. , Serzhenko Sergey S. , Sanin Dmitry B. , Styrov Sergey V. , Agibalov Dmitry Yu. , Korenev Sergey  V.
Published: August 2023

Brachytherapy with implantation of micro sources based on isotope 125I is a preferred treatment for localized prostate cancer without signs of germination of the gland capsule and in the absence of signs of metastases (stage cT1-T23aN0M0). Structural imaging methods (ultrasound, computed tomography, and magnetic resonance imaging) do not have high specificity in the differential diagnosis of prostate cancer. Hybrid technologies of radiation imaging (single-photon emission computed tomography/computed tomography, positron emission tomography/computed tomography, and positron emission tomography/magnetic resonance imaging) combine the advantages of high sensitivity of cross-sectional structural imaging methods (computed tomography and magnetic resonance imaging) and high specificity of molecular imaging methods (single-photon emission computed tomography and positron emission tomography) with tumorotropic radiopharmaceuticals. In this original clinical study, based on seven observations of localized prostate cancer (Gleason 67), it was shown that the precision of low-dose brachytherapy using 125I micro sources of localized prostate carcinomas, along with targeted biopsy, can be increased using hybrid methods of PSMA-receptor molecular imaging (single-photon emission computed tomography/ computed tomography, positron emission tomography/ computed tomography). The single-photon emission computed tomography/ computed tomography method is more accessible than positron emission tomography/ computed tomography. Moreover, when coupled with cold kits (HYNIC-PSMA), it allows research within any radioisotope diagnostics laboratory equipped with single-photon emission computed tomography/ computed tomography. The innovative technology of PSMA-navigation biopsy and brachytherapy, under the control of hybrid molecular imaging, can be used in primary and recurrent cases of localized prostate cancer, increases the accuracy and reduces the traumatic nature of procedures, and increases the medical and economic efficiency of low-dose brachytherapy with 125I micro sources. Further research is needed to improve the technology and evaluate its long-term results.
Influence of constant lighting on the morphofunctional state and rhythmostasis of the liver of rats
Authors: Grabeklis Sevil A. , Mikhaleva Liudmila M. , Kozlova Maria A. , Areshidze David A. , Dygai Alexander M.
Published: August 2023

BACKGROUND: There are evidences that light pollution, which causes melatonin deficiency and disruption of circadian rhythm, is associated with the development of malignant neoplasms of the liver, non-alcoholic fatty liver disease, biliary cirrhosis, and a number of other pathologies of this organ.
AIM: The aim of research was to study the features of chronic influence of constant lighting on lability of morphofunctional state of liver of mature Wistar rats and the structure of circadian rhythms of its parameters.
MATERIALS AND METHODS: The study was conducted on 80 rats divided into 2 groups: a control group kept under a fixed light regime (light/dark 12/12 h, lights on at 8:00 and off at 20:00), and an experimental group kept under constant lighting 24 h a day. The duration of the experiment was 3 weeks.
RESULTS: Its established that influence of constant light led to an increase in the size of hepatocytes and a decrease in nuclear-cytoplasmic ratio, average ploidy and proportion of binuclear hepatocytes, and also to development of fatty degeneration, a decrease in the expression of Bmal1 and Clock, and an increase in the expression of per2 and p53 in hepatocytes. At the same time, there was a decrease in glycogen content in hepatocytes. Dark deprivation also caused an increase in glucose levels, AST activity, and a decrease in blood levels of total protein and albumin. Constant lighting caused a rearrangement of the circadian rhythms of the area of nuclei, the area of the hepatocyte and nuclear-cytoplasmic ratio, Bmal1, per2, Clock expression, and led to destruction of Ki67 and p53 circadian rhythms in hepatocytes. Under conditions of constant lighting, the circadian rhythms of the content of lipids and glycogen in hepatocytes, ALT activity in the blood, and the content of total and direct bilirubin were also destroyed.
CONCLUSIONS: It has been established that constant illumination causes a restructuring of the circadian rhythms of a number of studied parameters against the background of morphological and functional changes, indicating a decrease in the adaptive capacity of the liver.
The study of the spectrum of pharmacological activity of the new original NT-3 mimetic dipeptide GTS-302
Authors: Nikiforov Dmitrii M. , Povarnina Polina Y. , Gudasheva Tatiana A. , Nadorova Anna V. , Kolik Larisa G. , Valdman Elena A. , Vakhitova Julia V. , Seredenin Sergey B.
Published: August 2023

BACKGROUND: The association of the pathogenesis of neurodegenerative diseases, depression, anxiety, and cognitive disorders with the deficit of neurotrophin-3 determines the prospect of creating drugs with a similar mechanism of action. Since the use of full-size neurotrophin-3 is limited by unsatisfactory pharmacokinetic properties, it is relevant to create low-molecular-weight mimetics of neurotrophin-3 that are active when administered systemically. A dimeric dipeptide mimetic of the 4th loop of neurotrophin-3, hexamethylenediamide bis(N--oxibutyryl-L-glutamyl-L-asparagine) GTS-302, which activates TrkC and TrkB receptors, has been developed at the V.V. Zakusov Research Institute of Pharmacology.
AIM: The aim of this study was to investigate the spectrum of pharmacological activity of GTS-302.
MATERIALS AND МETHODS: The pharmacological effects of GTS-302 were investigated following its intraperitoneal administration. The antidepressant-like activity of GTS-302 was studied in the forced swim test in mice after acute and 7-day administration. The anxiolytic and cognitive activity of the dipeptide were studied in the elevated plus maze test in mice and the novel object recognition test in rats after acute administration, respectively. The effect of GTS-302 on pain sensitivity was studied in the hot plate test in mice after acute administration.
RESULTS: It was found that GTS-302 exhibits antidepressant-like activity after acute administration at doses of 0.5, 1.0, 5.0 and 10 mg/kg. After 7-day administration, the antidepressant-like activity of GTS-302 was more pronounced in terms of effect size and statistical significance. The dipeptide GTS-302 at doses of 1.0, 5.0 and 10.0 mg/kg showed anxiolytic and cognitive activity and did not affect pain sensitivity.
CONCLUSIONS: The pharmacological spectrum of the low-molecular-weight mimetic of neurotrophin-3, dipeptide GTS-302, revealed upon systemic administration includes a number of neuropsychotropic effects characteristic of the full-sized neurotrophin. This allows us to consider GTS-302 as a potential neuropsychotropic drug.
The state of cancer care in Russia: age and cancer. Features of the localization structure of the quality of accounting and survival of patients with malignant tumors among the child population, adolescents and young adults in Russia (clinical and population study). Part 1
Authors: Merabishvili Vakhtang M. , Shakhzadova Anna O. , Kulyova Svetlana A. , Perelygin Vladimir V.
Published: August 2023

Currently, there are maximum opportunities for providing specialized oncological care to children and adolescents. Until the late 1980s, the official reporting in the USSR included the registration of cancer patients in the first age group from 0 to 29 years, which included children, adolescents, and young adults. Since 1989, the registration of cancer patients has been carried out in the USSR and Russia according to the recommendations of the International Association of Cancer Registries (IACR) for each five-year age group. However, a new problem emerged - where to classify young adults? In medicine and social sciences, young adults are considered to be individuals who have entered adulthood after the teenage period. Regarding oncology, we need to take into account the specific characteristics of the disease, primarily its structure, which significantly differs among children, adolescents, and young adults. When it comes to studying the specifics of oncopathology in young adults, it was challenging prior to the establishment of a system of population-based cancer registries, considering the relatively rare registration of primary cases of diseases in this population group. The creation of the population-based cancer registry in the Northwestern Federal District of Russia in 2019, serving a population of 13.9 million people more than the combined population of Belarus, Latvia, and Estonia provides unique opportunities to address the complex issues for this age group. This registry enables us not only to thoroughly examine the specific localization structure but also to calculate survival rates according to international standards.
Treatment of idiopathic sudden sensorineural hearing loss in diabetic patients by oral prednisolone
Authors: Khalefa Khaled M. Mokbel
Published: August 2023

Background: Ideopathic sudden sensorineural hearing loss should be treated urgently without delay by steroid therapy. The study purpose was to determine the efficacy of oral steroids in treatment of ISSNHL in patients with diabetes mellitus.
Methods: Prospective cohort study of diabetic patients with ISSNHL to evaluate the effectiveness of oral prednisolone in improvement of hearing. It included 30 patients aged 40-65 years that fulfilled the inclusion criteria. Oral prednisolone 1mg/kg was administered for 2 weeks. Hearing was assessed pre and post treatment by measuring the pure tune average in the form of mean and standard deviation. Blood sugar was monitored by a glucometer.
Results: 12 diabetic females and 18 diabetic males were enrolled in this study. There was highly significant improvement in the post treatment pure tune averages at all frequencies without any recorded side effects or complications.
Conclusions: Oral Prednisolone was highly efficient in rapid improvement of hearing in cases of ISSNHL in patients with diabetes mellitus with no need for intratympanic steroid injection in any patient. There was not reported any side effects or complications.
Centipede inside ear: utility of video otoscopy
Authors: Choorisaz Umer Sharief
Published: August 2023

Patients with ear related symptoms constitute a considerable group visiting primary health centres. Video otoscope is an upgraded version of traditional otoscope equipped with features that make it suitable for use among primary care physicians in diagnosing the diseases of ear and in removal of foreign bodies from ear. A 5-year-old child presented with sudden onset left ear pain and itching that woke her up from sleep. Examination with a video otoscope revealed a non-motile insect-like foreign body in the external auditory meatus. Upon proper removal under the guidance of video otoscopy, it was found to be a centipede mingled with cerumen. Contra lateral ear was also cleared of impacted cerumen. Patient’s ear ache and sense of ear blockage resolved and patient continued to be symptom free on follow-up. Video otoscopy is a useful technique and its introduction in primary care settings may lead to a better management of patients with ear related complaints.
A case of venous malformation of maxillary alveolar ridge managed with polydocanal injections and Er:Yag laser: a case report
Authors: Kumar Andrews N. , Mishra Chandan , Mishra Sandeep , Preet Emaan , Dua Gaurav
Published: August 2023

We present a case involving a venous malformation on the left maxillary alveolar ridge in an adult, which was successfully managed using a combination approach of Polidocanol injection and soft tissue Er:Yag laser. Vascular malformations (VM) encompass a group of anomalies affecting capillary, venous, lymphatic, and arterial systems, characterized by structural irregularities in blood vessels without endothelial proliferation. These anomalies are typically present at birth, can manifest in childhood or adolescence, and persist throughout life. In this specific case, a 65-year-old female patient presented with a bluish-black growth on her left maxillary alveolar ridge, later diagnosed as a VM. The treatment regimen involved Polidocanol injections, Quilting sutures, and ultimately excision with a 980-nm soft tissue Er:Yag laser. This combined approach, employing sclerotherapy, Quilt suturing, and Er:Yag laser with appropriate precautions, proved effective in managing the VM of the maxillary ridge, underscoring the significance of utilizing pharmacologic and surgical techniques for optimal management of vascular lesions.
Sudden onset palatal palsy-an iceberg in ENT
Authors: Shukla Stuti , Rizvi Sama , Tyagi Bhumesh
Published: August 2023

We report a case of isolated palatine paralysis in a 15-year-old boy. The patient presented with complaints of nasal regurgitation of liquids with nasal speech. The patient recovered in 10 days without any residual paralysis. Various causes, which include infections, trauma, tumor, and brainstem lesions, were investigated, but no predisposing factor was found. The patient responded well to conservative management.
Establishing reliability of dermatologist trained and validated evaluators for assessments of dermatological parameters: a comprehensive overview of concepts and techniques
Authors: Merja Apeksha M. , Patel Nayan K. , Patel Maheshvari N. , Yadav Megha K. , Jani Nistha A.
Published: August 2023

Background: Multi-centered, multi-visit outpatient dermatology studies provide participant-friendly convenience, drawing diverse volunteers while avoiding extended facility stays. However, maintaining a consistent dermatologist for such studies poses challenges, possibly leading to incomplete clinical readings and delaying accurate data collection from predefined datasets.
Methods: Led by a Dermatologist, the training aimed to ensure harmony in assessments among trained evaluators when utilizing digital photos to analyze dermatological parameters. It aimed to establish accord between the Dermatologist and Trained Evaluators for inter- and intra-observer evaluations. The training encompassed multiple parameters, such as Draize Scale, Fitzpatrick Skin Type, Glogau Skin Age Classification, IGA (Acne), PGA with Griffith Scale, and PGA for brittle nail signs.
Results: The results of the statistical analysis for photographic evaluation inter-evaluator reliability were evaluated. Based on the data, a strong correlation was observed between the Dermatologist's dataset and the Trained Evaluator's dataset. The Pearson chi-square test yielded a p-value of <0.05, indicating significant correlation among the trained evaluators' data compared to the dermatologist's data. All evaluators met the 80% acceptance criteria outlined in the training plan. Both evaluators and dermatologists were deemed suitable for dermatological assessments and photographic evaluations in relevant studies.
Conclusions: Theoretical training enabled evaluators to comprehend various dermatological parameters, including Draize Scale, Fitzpatrick Skin Type, Glogau Skin Age Classification, PGA with Griffith Scale, IGA (Acne), and PGA for brittle nail signs. Trained evaluators are now qualified to independently serve as "Dermatologist Validated and Trained Evaluators" in future studies. This approach is applicable for multi-centered, multi-visit dermatological clinical studies.
Case series of combination of carbon dioxide laser and topical 5-flourouracil for prevention of recurrence of keloid
Authors: Ittigi Vivekananda
Published: August 2023

The treatment of keloid has been a challenge, and at times, frustrating because of the recurrence. Hence, it is essential to find treatment modality with least recurrence and good cosmetic results. This study showed the effect of topical 5-fluorouracil following carbon dioxide (CO2) laser excision on recurrence of keloid. Case series of Total 24 patients (20 females and 4 males) of age group 12-56 years having keloid of duration 1-8 years were included in this study. Lesions were present on ear lobes, shoulder, chest, leg. CO2 laser was used in continuous mode to excise the lesions and all patients advised topical 5-FU (5%) once daily application over the lesion in the night, once re-epithelization started, for 4 weeks. The patients were followed up initially at every week for 4 weeks then every 4 weeks for 24 weeks to evaluate the response of treatment.  Of the 24 patients evaluated at 24 weeks, none (0%) showed any sign of recurrence. Out of 22 patients four (18.2%) patients complained of burning sensation/irritation. Three (13.6%) patients of erythema and erosion which cleared with temporary discontinuation of topical 5-FU and completed the 4 weeks of topical therapy. Three (13.6%) patients developed hypopigmentation.  Though response of this combination is encouraging in prevention of recurrence of keloid, recurrence on long term follow up need to be observed.
THE BOTTOM RELIEF OF VYZYRKA POND (ODESSA REGION, ODESSA DISTRICT)
Authors: Murkalov O. B. , Stoyan O. O.
Published: August 2023

Problem Statement and Purpose. For arid conditions of southern Ukraine, the problem of preservation and use of the local water resources has been relevant for a long time. One of the types of adaptation of economic activity to the natural conditions of the area is artificial water bodies’ creation. Operation of ponds without repair work led to reduction of the water surface area of most of them, siltation, reduction of depths, overgrowth, as a result of which the ponds from water accumulators turned into evaporators. The publications review devoted to ponds and artificial reservoirs showed that their hydrochemical, hydrobiological regime, hydrological elements and ecological condition are mainly studying. The purpose of the research is to establish the regularities of the relief structure of the bottom of the pond in the village of Vyzyrka.
Data & Methods. Field research was conducted in July 2021–2022. From two reservoirs, located within the village of Vyzyrka, the larger one was investigated. Work in the water area was carried out from the rowing boat Kolibri. The depths were determined with a Garmin Echo 200 echo sounder a geodetic rail. The use of the echo sounder made it possible to visually trace the relief of the bottom changes on the tacks and choose typical underwater points during relief measurements (ND31– 7.002.-2005). The depths were determined at 60 points, located evenly across the water area. The coordinates of measurement points were determined using a Garmin GPS72H GPS receiver. The journal of points was exported to Garmin Base Camp software.
Results. Vyzyrska Pond has existed as an artificial reservoir since 1923. The relief has a trough-like shape inherited from the beam relief. Three areas are distinguished in the structure of the bottom relief: flat bottom of the northern part; underwater continuation of concave coastal slopes; the central depression stretches along the axis of the reservoir from southeast to northwest. The creation and use of artificial reservoirs leads to the development of geomorphological processes associated with the interaction of the native relief, which was formed in other physical and geographical conditions, with the water environment. Further studies of the pond are aimed at establishing the spatial distribution of hydrological elements in the water area of the pond in order to establish patterns of their change, which are important for the aquatic biota development.
ENVIRONMENTALIZATION OF HOTEL AND RESTAURANT BUSINESS
Authors: Tereshchuk N. V. , Tranchenko L. V. , Tranchenko O. M. , Shashero A. M.
Published: August 2023

The aim of this article is to summarize and methodize the current information about ecological problems of hotel and restaurant sector, including Ukraine; to identify the main principles with the aim of ecologization of this tourism component based on world experience. Due to the current state of the world, Covid‑19 eco-friendly hotels are also in a good position. Greening is an added security health. Organic cuisine supports strong immunity. Natural and hypoallergenic materials in the hotel equipment have only a positive effect on the human body. Landscaping and interior landscaping spacious rooms provide cleaner air and favorable conditions for living, wellness, and rest. Worsening factors have emerged environmental indicators (increase in waste, mandatory individual packaging, etc.). The current state of hotel activities has led to the search for new one’s environmental measures and development strategies. In recent decades, the hotel business in Ukraine has been developing dynamically. Significant changes have been made for account of entering the market of hotel services of international networks such as Rixos, Rezidor, Hyatt, Wyndham Hotel Group. The policy of their activities contributed adjustments to the competitive position of the industry. Signs efficient hotel facility is a high level and quality control of services, environmental orientation, modern equipment and innovative technologies.
1470 Nm Diode Laser Effectiveness in Facial Fat Reduction with the Endolifting Technique: Pilot Study
Authors: Dias Layla , Almeida Denise , Borges Fábio dos Santos , Bravin Clarissa , Cruz Sonia , Caruso Priscila , Almeida Derbby , Bogado Carin
Published: August 2023

Introduction: Endolifting technique, also known as Endolaser or Endolift, consists of using a laser beam with a wavelength of 1470 nm emitted through an optical fiber inserted into the subdermal tissue in order to reduce subcutaneous fat and tone the skin through the intense production of collagen.
Objective: This study aimed to collect preliminary results about the effectiveness of the 1470 nm diode laser in reducing facial fat with the endolifting technique.
Material and methods: 10 patients were assisted with just one endolifting session, where the mandibular and submental regions were treated. It was by using 400 micron optical fiber, power ranging from 4 to 8 W, in continuous mode. After the procedure, patients were instructed to remain with a bandage on the treated area for 4 days and. Then, after this period they received 4 sessions of manual lymphatic drainage, which was performed once a week.
Results: After treatment and reassessment at the end of 60 days, it was noticed a clear decrease in fat in the cheeks, as well as in the submental region. Also, the skin where the jowl fat was removed underwent intense retraction, as it was seen a decrease in flaccidity and wrinkles.
Conclusion: It was concluded that the endolifting technique is extremely effective in promoting the reduction of unsightly subcutaneous fat on the face and neck, as well as indirectly intervening in the skin to promote rejuvenation to varying degrees. Likewise, this technique can be attested as a safe method due to the absence of complications or intercurrences throughout the care and follow-up of patients after treatment.
Adjustments to Stimulation Frequency and Duration of STEP VEPs in Paediatric CVI
Authors: Mackay A M
Published: August 2023

Recent research has demonstrated that the agreement between VEP and subjective VA is influenced by both technical and clinical factors [1-3].  In normal visual development, spatial resolution threshold is limited by the density of retinal bipolar cells [4] which initiate three distinct functional pathways; magnocellular, parvocellular, and koniocellular [5].  Ophthalmological conditions during development with pathology before the LGN and resulting in moderate or severe visual impairment [6] may preferentially preserve the magnocellular pathway making steady state VEPs the ideal assessment.
Issues and Concerns of Teachers Towards Modular Distance Learning Approach
Authors: Jayme Ronald , Maguate Guarin
Published: August 2023

This research investigated the teachers’ issues and concerns towards modular distance learning approach. This study aimed to determine the level of issues and concerns encountered by teachers in the implementation of modular distance learning approach and the significant difference in the level of issues and concerns of teachers towards modular distance learning approach when grouped according to sex, number of years in service and number of related trainings. The study employed quantitative research, specifically a descriptive research design to determine the issues and concerns of fifty (50) elementary teachers of Cadiz District II in the Schools Division of Cadiz City. Total Purposive Enumeration sampling was used in selecting the respondents for the target samples. They were grouped according to the schools they are stationed at. The statistical tools used for the treatment of data were mean and standard deviation for problems 1 and 2, Independent t-test, and One-Way ANOVA used for problems 3 and 4. The results revealed that the teachers have high level of issues and concerns encountered towards modular distance learning approach. Moreover, the result of this investigation suggested that females have higher competencies on the level of issues and concerns of teachers towards modular distance approach than males. Therefore, the null hypothesis is rejected as a significant difference exists in the issues and concerns of teachers towards Modular Distance Learning approach when grouped according to sex. On the other hand, the null hypothesis is accepted as no significant difference exists in the issues and concerns of teachers towards Modular Distance Learning approach when grouped according to number of years in service and number of related trainings.
The Influence of Job Placement and Competence Mediation of Job Satisfaction in Increasing the Performance of State Civil Apparatus in Industrial and Trade Services of The Province of Bali
Authors: Adhi Dwiswara Gde Made , Sudja I Nengah , Dwi Widyani A.A.
Published: August 2023

This study aims to determine the effect of Job Placement and Competence on Job Satisfaction in Improving the Performance of State Civil Servants at the Office of Industry and Trade of the Province of Bali. This research was conducted at the Office of Industry and Trade of the Province of Bali with a total sample of 84 people using the saturated or total sampling method. Data collection using a questionnaire. All data obtained from the distribution of questionnaires is feasible to use, then analyzed using variant-based Structural Equation Modeling (SEM) known as Partial Least Square (PLS) analysis. The results showed that (1) Work Placement has a positive and significant effect on Job Satisfaction, (2) Competence has a positive and significant effect on Job Satisfaction, (3) Work Placement has a positive and significant effect on Performance, (4) Competence has a positive and significant effect on Performance, (5) Job Satisfaction has a positive and significant effect on Performance, (6) Job Satisfaction can mediate the effect of Job Placement on Performance, (7) Job Satisfaction can mediate the influence of Competence on ASN Performance at the Bali Provincial Industry and Trade Service ASN.
Assess the Effect of Factors on the Digital Transformation Decision of Businesses in Vietnam
Authors: Hoang Thanh Tung , Nhi Vu Tue
Published: August 2023

The study examines the factors affecting the digital transformation decision of enterprises in Vietnam. Based on behavioral theoretical models and empirical studies on digital transformation, the research team collects and analyses data using Smart PLS software. The research results have shown five positive factors and one negative impact on the intention of enterprises to convert digitally in Vietnam. In addition, the research team conducts an additional assessment of the influence level of the factors through statistics that describe the average value of the element. The outcome of the analysis and evaluation is the foundation for proposing solutions to promote businesses in Vietnam to implement digital transformation
GERMINAR A CIÊNCIA INTERDISCIPLNAR
Authors: Pimentel Adelma , Seibt Cezar Luís , De Oliveira Silva Maria de Nazareth , Nunes Sérgio
Published: August 2023

A comunicação científica divulgada pela CompleXitas carrega nas camadas de seu campo semântico os significados de Renovar-se e Germinar. No âmbito gramatical os signos apostos neste editorial são sintaticamente delineados como verbos. Estes fundamentos estão presentes no volume 6/1/2022 na ação de manter o periódico como um dos canais de divulgação nos horizontes da Interdisciplinaridade, Fenomenologia e Hermenêutica. Além de agir é necessária a vida humana avaliar o percurso existencial para manter o curso da vida justa e boa a todos; igualmente, em um periódico científico a avaliação favorece parâmetros para manter as premissas que o sustentam e atualizar os suportes. Estes preceitos permeiam o intervalo ocorrido entre as publicações.