bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical implications of T-Cells CX3CR1+, Toll-like Receptor 4 signaling pathway, and immune checkpoints in Non-Muscle Invasive Bladder Cancer
Authors: Alonso João Carlos Cardoso , De Souza Bianca Ribeiro , Camargo Gabriela Cardoso de Arruda , De Oliveira Gabriela , Durán Nelson , De Freitas Leandro Luiz Lopes , Billis Athanase , Fávaro Wagner José
Published: May 2023

Background: This study characterized and compared the molecular profiles of CX3C chemokine receptor 1 (CX3CR1, a marker of T-cell differentiation), Toll-like receptor 4 (TLR4)-mediated interferon signaling pathway, and immune checkpoints in the different histological stages of non-muscle invasive bladder cancer (NMIBC), aiming the investigation of these biomarkers as a criterion of clinical response to immunotherapy. Methods: Seventy-five formalin-fixed paraffin-embedded samples of bladder were obtained from 34 to 96-year-old patients (mean 65 years) with NMIBC diagnosis in University of Campinas (UNICAMP) and Paulinia Municipal Hospital/ Brazil. Subsequently, the samples were divided into 3 groups (n= 25 samples per group): pTis group, high-grade pTa group, and pT1 group; and submitted to immunohistochemistry analysis: TLR4-mediated IFN-γ production signaling pathway (TRIF, TBK1, IRF-3, IFN-γ), CX3CR1+CD8+ T-cells, immune checkpoints (PD-1/PD-L1 and CTLA-4), and regulatory T (Treg) cells (FOXP3). The retrospective anonymous study was approved by the local ethics committee (Clinical Trial: RBR-6swqd2). Results: pTis group showed the lowest activation of TLR4-mediated IFN-γ signaling pathway when compared (p<0.01) to high-grade pTa and pT1 groups. Both the immunoreaction intensity and positive cells percentage were lower (p<0.01) for TLR4, TRIF, IRF-3, and IFN-γ in the pTis group with respect to other groups. No statistical difference was found between high-grade pTa and pT1 groups for these biomarkers. Likewise, CX3CR1 immunoreactivities were remarkably lower (p<0.01) in the pTis group in comparison with high-grade pTa and pT1 groups, which did not show statistical differences between them. Furthermore, immune checkpoints (PD-1/PD-L1 and CTLA4) and FOXP3+ Treg cells immunoreactivities were significantly higher (p<0.01) in the high-grade pTa and pT1 compared to the pTis group. Conclusions: Our data demonstrated that pTis stage was characterized by an immunosuppressive microenvironment in comparison with pTa and pT1 stages, showing decreased TLR4-mediated interferon signaling pathway and low activation of CX3CR1+CD8+ T-cells; which implies in low sensitivity to immunotherapy. The larger number of FOXP3+ Treg cells in pTa and pT1 was correlated with intensified immune checkpoints immunoreactivities, indicating higher sensitivity to immunotherapy. Finally, these biomarkers may be useful in the clinical management of patients with NMIBC.
Análise de rotulagens de marcas de suplementos de proteína do soro do leite em pó (Whey Protein) segundo a RDC N° 18, 27 de abril de 2010
Authors: Bezerra Alane Nogueira , Dos Santos Bruna Saraiva , Pereira Camila Pinheiro , Lopes Euclides David Rodrigues , Da Costa Hugo Leonardo Barroso , Gomes Isabela Limaverde , Amâncio Lívia Carolina , Melo Mateus Azevedo Ursulino
Published: May 2023

A indústria de suplementos alimentares cresceu nos últimos anos, principalmente a venda de suplementos à base de proteínas em pó e estas são bastante utilizadas por praticantes de musculação, interessados pelo ganho de massa muscular. Com o intuito de prevenir a utilização indiscriminada do consumo de suplementos proteicos por praticantes de atividade física, o presente estudo objetivou avaliar os rótulos de proteína do soro do leite `` whey protein ´´ comercializados em lojas de Fortaleza – CE, segundo os padrões RDC n° 18, 27 de abril de 2010. Trata-se de um estudo quantitativo, exploratório e descritivo, onde realizou –se uma análise de diferentes marcas de suplementos proteicos do soro do leite. As amostras foram selecionadas conforme indicação de suplementos proteicos, sendo analisadas de acordo com disponibilidade das lojas, do município de Fortaleza – CE. Foram avaliadas 20 marcas, destas, apenas 80% estavam conforme a legislação, enquanto 20% estavam em desacordo.  Com relação às não conformidades, destacou –se a ausência da informação `` As expressões: anabolizantes, hipertrofia muscular ´´ em 20% dos rótulos, quanto a designação ``Imagens e ou expressões referentes a perda de peso, ganho de massa muscular ́ ́ 10% estavam em desacordo.  Quanto à adição de fibras, 75 % estavam em desacordo com a legislação. Com isso, destaca-se, a necessidade de fiscalização contínua e eficaz dos rótulos de suplementos destinados a atletas e praticantes de atividade física, com garantia de que os consumidores tenham acesso a informações fidedignas sobre o produto. Conclui-se que grande parte dos rótulos de suplementos proteicos para atletas apresentavam algum tipo de inadequação de acordo com o objetivo proposto.
Fast Blood Oxygenation through Hemocompatible Asymmetric Polymer of Intrinsic Microporosity Membranes
Authors: Huang Xinxi , Huang Junping , Su Pengcheng , Li Wanbin
Published: April 2023

Membrane technology has attracted considerable attention for chemical and medical applications, among others. Artificial organs play important roles in medical science. A membrane oxygenator, also known as artificial lung, can replenish O
2
and remove CO
2
of blood to maintain the metabolism of patients with cardiopulmonary failure. However, the membrane, a key component, is subjected to inferior gas transport property, leakage propensity, and insufficient hemocompatibility. In this study, we report efficient blood oxygenation by using an asymmetric nanoporous membrane that is fabricated using the classic nonsolvent-induced phase separation method for polymer of intrinsic microporosity-1. The intrinsic superhydrophobic nanopores and asymmetric configuration endow the membrane with water impermeability and gas ultrapermeability, up to 3,500 and 1,100 gas permeation units for CO
2
and O
2
, respectively. Moreover, the rational hydrophobic–hydrophilic nature, electronegativity, and smoothness of the surface enable the substantially restricted protein adsorption, platelet adhesion and activation, hemolysis, and thrombosis for the membrane. Importantly, during blood oxygenation, the asymmetric nanoporous membrane shows no thrombus formation and plasma leakage and exhibits fast O
2
and CO
2
transport processes with exchange rates of 20 to 60 and 100 to 350 ml m
−2
min
−1
, respectively, which are 2 to 6 times higher than those of conventional membranes. The concepts reported here offer an alternative route to fabricate high-performance membranes and expand the possibilities of nanoporous materials for membrane-based artificial organs.
Acción génica en líneas contrastantes de maíz (Zea mayz L.)
Authors: Banda Armando Espinoza , Grijalva Oralia Antuna , Rodríguez José Luis Coyac , Enríquez Enrique Andrio
Published: May 2023

El objetivo fue estimar los efectos de aptitud combinatoria general (ACG) y la aptitud combinatoria específica (ACE) en líneas de maíz y sus cruzas. Se utilizaron nueve líneas de maíz, divididas en dos grupos: el primero, como machos, formado por cuatro líneas de la Universidad Autónoma Agraria Antonio Narro Unidad Laguna (UAAAN-UL) derivadas de la Población-60 que se caracterizan por su adaptación a la Comarca Lagunera. El segundo, dos líneas recicladas del banco de germoplasma de CIMMYT (L25 y L26 de ciclo precóz-Intermedio, de grupo heterótico A adaptadas al Sub trópico y, tres líneas (L23, L27 y L28) de la UAAAN-UL que provienen de la cruza de Población-61 x LAN 388P línea enana, con hojas anchas y verticales generada a partir de la tercera generación del híbrido AN-388. En 2013 se generaron 20 cruzas por el método II de Carolina del Norte. Se evaluaron en abril de 2014 en un diseño de bloques al azar, dos repeticiones y riego normal. La parcela fue de dos surcos de 3.0 m de largo y 0.75 m de ancho y 0.17 m entre planta, una densidad de 78, 431 plantas por hectárea. Se fertilizó con la fórmula 180-90-00. Se tomaron datos de Floración masculina (FM), Femenina (FF), Altura de planta (AP) y Mazorca (AMz), dimensiones de mazorca: diámetro DMz), longitud (LMz), numero de hileras (NH) y granos por hilera (GH) y, rendimiento de grano (Rend). Los 20 híbridos experimentales fueron significativamente diferentes (p≤0.01) en nueve de las variables.  Los probadores machos (M), fueron diferentes (p≤0.05) en floración femenina (FF) y altamente significativa (p≤0.01) para floración masculina (FM) y longitud de mazorca (LMz), en tanto que el resto fue no-significativo (AP, AM, HMz, GH, DMz y Rend). En contraste, las hembras (H), mostraron mayor diversidad, pues se observaron diferencias (p≤0.05) para hileras por mazorca (HM) y, diferencias altamente significativas (p≤0.01) para: FM, FF, AP, LMz, GH, DMz y Rend. En las líneas hembra se observó mayor diversidad que en los machos usados como probadores. La interacción MxH fue significativamente diferente para FF y dimensiones de la mazorca (LMz, GH y DMz) además de Rend. Tres de las Líneas Macho (L1, L2, L3) mostraron ACG positiva y significativa para Rend, en cambio en las hembras solo las L23 y L28 fueron significativas. Los mayores efectos de ACE positivos y significativos se observaron en seis de las 20 cruzas donde 2x26, 5x26 y 6x28 mostraron los mayores rendimientos de grano. La acción génica aditiva y no-aditiva fueron de importancia en el presente estudio.
Habronemose cutânea equina no extremo sul da Bahia
Authors: Merlo Valéria Drosdoski , Maciel Sarah Costa , Jadjescki Caio Alexssander Ramiro , De Aguiar Trystan Nascimento , Salvador Ariela Zoppi , Rondon Diogo Almeida , Melotti Vitor Dalmazo , Marcolongo-Pereira Clairton
Published: May 2023

A habronemose cutânea equina é uma dermatose que acomete cavalos causada pelo nematódeo do gênero Habronema. Esses parasitas quando estão em seu ciclo errático, permanecem na pele e não conseguem evoluir seu ciclo biológico, o que inicia uma reação de hipersensibilidade como reposta orgânica ao parasita presente, resultando em lesões que não cicatrizam envoltas por tecido de granulação. O objetivo desse trabalho é descrever um caso de habronemose cutânea equina abordando suas características clínico-patológicas e diferenciais. Um equino, macho, de 9 anos de idade, Quarto de Milha, proveniente do município de Teixeira de Freitas, região do extremo sul baiano foi atendido com uma ferida não cicatrizante em região ventral do tórax. A lesão foi excisada e encaminhada para exame histopatológico que confirmou o diganóstico de habonemose cutânea. No Brasil, a casuística de habronemose é alta devido a falta de controle dos parasitas intermediários. As lesões tendem a se localizar em de membros e face previmente lesadas. O tratamento medicamentoso pode ser realizado com ivermectina, mas a terapia mais indicada é a ressecção cirúrgica da área afetada. Assim, a habronemose cutânea é uma importante causa de lesão cutânea em cavalos e deve ser incluída no diagnóstico diferencial das doenças que causam feridas que não cicatrizam nos equídeos.
Gestión Sostenible de Riesgos de Desastres de los Gobiernos Regionales, Locales (Provincias – Distritos), Poder Ejecutivo
Authors: Sandoval Jorge Lescano , Sena Lucía Emperatriz Valdéz , Vega Marlitt Florinda Naupay
Published: May 2023

Se presenta la frondosa normativa que se aplica en el Perú para efectos de una eficaz y eficiente gestión de riesgos de desastres naturales.  A la luz de dicha normativa se requiere con urgencia replantear la gestión, sobre la base de un estudio del medio físico. Por otro lado, es necesario un mayor conocimiento de la normativa sobre todo los entes decisores (autoridades).
Hispidulinin Sağlıklı Hücre Hatlarında Sitotoksik, Apoptotik ve Nekrotik Etkilerinin Değerlendirilmesi
Authors: AYSİN Ferhunde
Published: April 2023

Hispidulin çeşitli farmakolojik özelliklere sahip olmasından dolayı uzun süredir kanser araştırmalarında kullanılmaktadır ancak bu maddenin sağlıklı hücrelerde sitotoksik etkisiyle ilgili sınırlı sayıda çalışma bulunmaktadır. Bu çalışmada ilk defa, hispidulin geniş doz aralığında (0-800 μM) sağlıklı hücre hatları ile denendi ve kulanımının güvenliği MTT ve Akım sitometrisi analizleriyle değerlendirildi. Bu amaçla, İnsan akciğer fibroblastı (MRC-5), Sıçan Primer Akciğer Fibroblastı (RA-6013) ve Sıçan Primer Trakeal Fibroblastı (RA-6217) hücreleri 48 saat boyunca hispidulinle muamele edildi. Hispidulin, düşük dozlarda hücre canlılığı üzerinde önemli etkiler göstermedi ancak özellikle 400 ve 800 μM dozlarında hücrelerin canlılığında istatistiksel anlamda ciddi bir azalmaya neden oldu. Hispidulinin IC50 değeri, MRC-5 hücreleri için 563.63 µM, RA-6013 hücrelerinde 194.30 µM ve RA-6217 hücrelerinde ise 311.98 µM olarak belirlendi. Ayrıca 800 μM hispidulin, tüm sağlıklı hücreler üzerinde güçlü apoptotik ve nekrotik etki gösterdi. Sonuçlarımız, hispidulinin düşük dozlarda (0-200 μM) sağlıklı hücrelerde antisitotoksik nitelikte olduğunu ve gelecekteki kanser ve solunum yolu hastalıkları tedavisi için güvenilir doğal bir bileşik olma potansiyeline sahip olduğunu göstermektedir.
CITRA MEREK DAN KEPUTUSAN PENGGUNA GRAB BIKE DI ERA NEW NORMAL PADA GENERASI Z DI KOTA PALEMBANG
Authors: Resika Yeri
Published: April 2023

This research is aimed at finding out the effect of brand image on the decisions of Grab Bike users in Palembang City. The research was conducted on Sekolah Tinggi Ilmu Ekonomi (STIE) APRIN Palembang students. Quantitative research is the type of research used and the research technique used, namely the technique of collecting research data with a questionnaire using a Likert scale. The research was conducted on Grab Bike users with a total of 79 respondents. Samples were taken using a non-probability sampling method, the snowball sampling method was chosen. The research data analysis method is linear regression. The results obtained from this research will be used to enrich knowledge about marketing research. Based on the results obtained, namely the indicators of the research variables, they are valid and reliable. The result of the coefficient of determination (R²) is 0.301 or 30.1%, which explains that the relationship of variable X to variable Y is positive but not significant. Brand image can explain purchasing decisions by 30.1%, while 60.9% is explained by other factors not included in this study. Simple linear regression testing shows that the regression coefficient of the brand image variable is 0.432 with a positive value, which means that every time there is an increase in the brand image by one point and other variables have a fixed value, the user's decision will increase by 0.432 units. The constant value of 3,976 indicates that when a company has a good brand image, the value of user decisions about Grab services will increase.
PENGARUH RETURN ON ASSET DAN EARNING PER SHARE TERHADAP HARGA SAHAM PERUSAHAAN SEKTOR ENERGI YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Moerdianto Refor Moerdianto , Anto Andi Sayyidatun Ufairah , Gazali Yuni Pratiwi , Kartini Kartini Kartini , Rura Yohanis Rura
Published: April 2023

Investasi saham merupakan salah satu investasi yang menarik banyak investor dan harga saham merupakan hal yang menarik bagi investor dan pemegang saham karena dari perubahan harga saham investor dapat memperoleh keuntungan berupa capital gain. Penelitian ini bertujuan untuk menguji pengaruh return on asset dan earning per share terhadap harga saham di perusahaan sektor energi yang terdaftar di bursa efek Indonesia periode 2019-2021. Sampel dalam penelitian ini diperoleh dengan menggunakan teknik nonprobability sampling, sehingga diperoleh sampel sebanyak 66 perusahaan dari 74 populasi perusahaan sektor energi yang terdaftar di bursa efek Indonesia. Teknik analisis data yang digunakan dalam penelitian yaitu teknik regresi linear berganda. Hasil dari penelitian ini yakni Secara simultan return on asset dan earning per share berpengaruh terhadap harga saham pada perusahaan sektor energi yang terdaftar di Bursa Efek Indonesia periode 2019-2021. Secara parsial variabel return on asset berpengaruh negatif terhadap harga saham pada perusahaan sektor energi yang terdaftar di bursa efek Indonesia periode 2019-2021. Dan secara parsial variabel earning per share berpengaruh posistif terhadap harga saham pada perusahaan pada perusahaan sektor energi yang terdaftar di bursa efek Indonesia periode 2019-2021.
PENGARUH TINGKAT INFLASI DAN TINGKAT SUKU BUNGA TERHADAP HARGA SAHAM (STUDI KASUS PERUSAHAAN TAMBANG YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2017-2021)
Authors: DEPI SRI , Nersiyanti Nersiyanti
Published: April 2023

This study aims to examine the effect of inflation and interest rates on stock prices in mining companies listed on the Indonesian Stock Exchange in 2017-2021. The type of data used in this research is quantitative data in the form of financial reports from 2017-2021, and reports from Bank Indonesia on interest rates and inflation rates. The sample in this study amounted to 36 companies. Data analysis techniques in this study used the classical assumption test, hypothesis testing, multiple linear regression, and the coefficient of determination test. Data processing in this study used the SPSS Software (Statistics Package for the Social Sciences) 20.0 for windows. The results of this study prove that the inflation rate has a negative and significant effect on stock prices, while interest rates do not have a significant effect on stock prices. Simultaneously inflation and interest rates have no effect on stock prices.
Pengaruh Motivasi Dan Disiplin Kerja Terhadap Kinerja Pengawai Pada Kantor Camat Kecamatan Sanga Desa
Authors: Heriyana Heriyana , Erlina Neti
Published: April 2023

Penelitian ini bertujuan untuk mengetahui Seberapa pesar pengaruh Motivasi dan disiplin kerja pagawai terhadap kinerja pegawai Kantor Camat Kecamatan Sanga Desa. Penelitian ini mengggunakan data primer maupun sekunder. Teknik analisis penelitian ini menggunakan metode kuantitatif dimana menggunakan persamaan statistika dalam mengolah dan melakukan pembahasan data yang diperoleh dari responden melalui media kuesioner. Metode analisis yang digunakan adalah menggunakan Metode Regresi Linear Berganda. Hasil penelitian ini menunjukkan bahwa Nilai r sebesar 0,561. Hal ini menunjukkan bahwa terjadi hubungan yang sedang antara motivasi (X1) dan disiplin kerja (X2) terhadap kinerja pegawai (Y). Karena nilai R berada pada rentang  0,400 sampai dengan 0,599 dengan intepretasi koefisien kolerasi sedang. Diketahui nilai Adjusted R Square sebesar 0,395, maka memiliki arti bahwa variable motivasi dan disipli kerja memberikan sumbangan pengaruh secara bersama-sama sebesar 39,5% terhadap variable kinerja pegawai dan sisanya 60,5%  dipengaruhi variable lain di luar penelitian ini. Hasil uji t (Test) menunjukkan bahwa variabel motivasi (X1) thitung sebesar 1,189 sedangkan ttabel pada taraf signifikansi 5% dengan df = 44-2= 42 adalah 1,680 dikarenakan thitung > ttabel (1,189 < 1,680) maka Ho diterima Ha ditolak, sedangkan  variabel disiplin kerja (X2) thitung sebesar 2,778, sedangkan ttabel pada taraf signifikansi 5% dengan df = 44-2= 42 adalah 1,680 dikarenakan thitung > ttabel (2,778 > 1,680) maka Ho ditolak Ha diterima. Artinya motivasi (X1) dan disiplin kerja (X2) berpengaruh positif terhadap kinerja pegawai  Kantor Camat Kecamatan Sanga Desa.
TRUST MEMEDIASI ONLINE CUSTOMER REVIEW DAN RATING TERHADAP MINAT BELI MELALUI MARTKETPLACE SHOPEE
Authors: Wibowo Nidia Agustin , Safitri Koko
Published: April 2023

This study used quantitative data and the data collection method used in this study was a questionnaire using a Likert scale. The population used in this study were STIE Sampit students who used Shopee as a place to shop online. While the sample in this study amounted to 75 respondents and used a sampling technique based on accidental sampling, namely based on the coincidence of anyone who met and made a purchase at the shopee marketplace. The results of this study indicate that (1) online customer reviews have a significant effect on purchase intention with a t statistic value of 2.664 (2) online customer reviews have a significant effect on trust with a t statistical value of 4.709 (3) online customer ratings have no effect on purchase intentions with a t value statistic 1.028 (4) online customer rating has a significant effect on trust with a t statistic value of 4.555 (5) trust has a significant effect on purchase intention with a t statistic value of 2.346 (6) trust mediates online customer review of purchase intention with a t statistic value of 2.029 (7) trust mediates online customer rating of purchase intention with a statistical t value of 2.019. The R Square result of buying interest is 0.393 indicating that the research model is classified as moderate and means that online customer reviews, online customer ratings, and trust together contribute to buying interest of 39.9% and the rest is influenced by other variables outside of this study.
PENGARUH PENGGUNAAN TEKNOLOGI INFORMASI DAN ORIENTASI PASAR TERHADAP KINERJA PELAKU UMKM GERAI PONSEL DI KECAMATAN MEDAN AMPLAS
Authors: Damayanti Dina , Falahi Adrial
Published: April 2023

This study aims to determine the effect of the use of information technology and market orientation on the performance of MSME actors at cellphone outlets in Medan Amplas District. This study uses descriptive and quantitative methods, the population is all the owners of mobile phone outlets in the District of Medan Amplas as many as 84 cell phone outlets. The location of this research is the Mobile Phone Outlet in Medan Amplas Subdistrict, North Sumatra, which starts from January to October 2022. The sampling technique for this research uses Saturated Samples, so that the research sample is set at 84 cellphone outlets. The results of this study indicate the multiple linear regression equation obtained by the equation Y = 1.369 + 0.355X1 + 0.532X2. The results of the t-test obtained that the value of tcount = 7.705 > ttable 1.663 and a significance of 0.000 <0.05, then Ha is accepted and Ho is rejected, which means that the Information Technology variable (X1) partially has a significant influence on the performance of MSME actors in Mobile Phone Outlets in Medan Amplas District. The value of tcount = 4.377 > ttable of 1.663 and a significance of 0.003 <0.05, then Ha is accepted and Ho is rejected, which means that the Market Orientation variable (X2) partially has a significant influence on the performance of MSME actors in Mobile Phone Outlets in Medan Amplas District. The results of the F test obtained a positive value of Fcount = 79,171>Ftable = 2.72 and a significance of 0.000 <0.05, meaning that information technology and market orientation variables simultaneously have a positive and significant effect on the performance of MSMEs at Mobile Phone Outlets in Medan Amplas District. The value of Adjusted R Square (R2) is 0.842 or 84.2%, while the remaining 15.8% is explained by other variables not examined in this study. So this research concludes that the use of Information Technology (X1) and Market Orientation (X2) affects the performance of MSME Actors at Mobile Phone Outlets (Y) in Medan Amplas District.
ANALISIS PENGARUH TERJADINYA AUDIT DELAY PADA PERUSAHAAN SARANA DAN PRASARANA YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2019-2021
Authors: AULIA CHANIA , Setiawati Erma
Published: April 2023

ABSTRAK

 

Penelitian ini dilakukan untuk menganalis pengaruh Ukuran Perusahaan, Profitabilitas, Solvabilitas, Komite Audit, dan Earning Per Share terhadap Audit Delay Studi kasus Terhadap Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021. Sampel yang digunakan dalam penelitian ini adalah perusahaan sarana dan prasarana sub sektor real estate, building infrastructure, utilities dan transportation di Bursa Efek Indonesia (BEI) periode tahun 2019 - 2021. Berdasarkan hasil pengujian didapatkan kesimpulan sebagai berikut hasil pengujian secara simultan menunjukan bahwa Ukuran Perusahaan, Profitabilitas, Solvabilitas, Komite Audit, dan Earning Per Share berpengaruh signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021. Hasil pengujian secara parsial menunjukan bahwa Solvabilitas, berpengaruh negative signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021. Hasil pengujian secara parsial menunjukan bahwa Komite Audit berpengaruh positif signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 -2021. Hasil pengujian secara parsial menunjukan bahwa Ukuran Perusahaan, Profitabilitas, dan Earning Per Share tidak berpengaruh signifikan Terhadap Audit Delay Pada Perusahaan Sarana dan Prasarana Yang Terdaftar Di Bursa Efek Indonesia Tahun 2019 - 2021.
ANALISIS KOMPENSASI DAN KOMPETENSI TERHADAP KINERJA KARYAWAN PADA CV GENCAR LAKSANA MANDIRI
Authors: Arumingtyas Fida , Megaster Tekni , Susiati Asriani
Published: April 2023

The purpose of this study was to determine the effect of compensation and competency on employee performance either partially or simultaneously at CV Gencar Laksana Mandiri. This study uses an descriptive method with a quantitative approach. Sampling was 38 people. Data processing was assisted by SPSS software version 25. If it is projected based on multiple regression tests it shows that the higher the value of compensation (X1) and competency (X2) simultaneously at a certain value, then the performance value (Y) increases at certain value too. Simultaneously compensation and competence have a significant effect on employee performance at CV.Gencar Laksana Mandiri. Partially, compensation has a positive and significant effect on employee performance, while competence also has a positive and significant effect on employee performance at CV.Gencar Laksana Mandiri.
PENGARUH DANA PIHAK KETIGA, LDR, ROA, DAN ROE TERHADAP JUMLAH PENYALURAN KREDIT
Authors: Permatasari Intan Yunnyarti , Suwarno Agus Endro
Published: April 2023

This study aims to determine the effect of Third Party Funds, LDR, ROA, and ROE on the amount of lending in all commercial banks listed on the IDX for the period 2013-2018. The population in this study were all commercial banks listed on the IDX for the period 2013-2018. The data collection technique in this study used a documentation study. To analyze the research using the Multiple Linear Regression analysis method assisted by the SPSS 17 program. The results of the study prove that third party funds, LDR, ROA and ROE simultaneously affect the amount of credit disbursement. the results of the coefficient of determination test (R2) obtained a value of 69.9% of the independent variables affect the distribution of commercial bank loans and the remaining 30.1% is influenced by other variables not examined in this study.
STUDI LITERATUR PENGGUNAAN PRODUK BANK SYARIAH DI ERA GEN Z
Authors: Purba Pria Mitra , Amandha Azrah Cipta , Chairina Chairina
Published: April 2023

This research is a literature study that discusses the use of Islamic bank products in the Gen Z era. In research, of course, results will be found on how the Z generation is involved, especially in using Islamic bank products. This literature study aims to discuss more deeply regarding the use of Islamic bank products, what are the advantages and related to the use of Islamic bank products and how the current generation responds to using Islamic bank products. In this study the data obtained through primary data obtained from distributing questionnaires to students with a sample of 12 respondents. This research method also uses a quantitative approach by exploring and studying various existing sources and looking at the current situation and conditions. The results of this study indicate that the use of Islamic bank products has a significant influence on the z generation. This can be seen from the amount of interest and data that has been studied both on previous sources and data reviewed through interviews with respondents.
PENGARUH UKURAN PERUSAHAAN, RETURN ON ASSET (ROA), DEBT TO EQUITY RATIO (DER) DAN CURRENT RATIO (CR) TERHADAP AUDIT DELAY
Authors: Arindi Putra Renaldi , Subiyanto Bambang
Published: April 2023

Audit Delay yang melewati batas waktu ketentuan POJK Nomor : 14/POJK.04/2022 akan berakibat pada keterlambatan publikasi laporan keuangan. Keterlambatan publikasi laporan keuangan mengindikasikan adanya masalah dalam laporan keuangan perusahaan sehingga memerlukan waktu yang lebih lama untuk menyelesaikan audit. Tujuan dari penelitian ini adalah untuk mendapatkan bukti empiris dan menganalisis pengaruh ukuran perusahaan, return on asset, debt to equity ratio, dan current ratio terhadap audit delay. Variabel audit delay diukur dengan variabel dummy dengan kriteria apakah perusahaan melewati batas pelaporan atau tidak melewati batas Pelaporan Keuangan tahun 2017-2021. Jumlah populasi dalam penelitian ini 142 perusahaan dengan 35 perusahaan yang menjadi sampel penelitian, akhirnya keseluruhan observasi 175. Penelitian ini menggunakan data sekunder yang diperoleh dari bursa efek Indonesia dan situs resmi dari masing-masing perusahaan. Pengambilan data dalam penelitian ini menggunakan teknik purposive sampling. Teknik analisis yang digunakan adalah analisis regresi logistik. Pengolahan data menggunakan aplikasi SPSS 26. Hasil penelitian menunjukan ukuran perusahaan dan return on asset memiliki pengaruh negatif signifikan terhadap audit delay, debt to equity ratio dan current ratio memiliki pengaruh positif signifikan terhadap audit delay,
PENGARUH BEBAN KERJA DAN TEAMWORK TERHADAP KEPUASAN KERJA DAN PRODUKTIVITAS KERJA KARYAWAN PADA PT PERTAMINA HULU ROKAN ZONA XXX
Authors: Pratama Fadhil Rifqi , Hendriani Susi , Machasin Machasin
Published: April 2023

Oil and gas industry is one of the industry that demand human resources with high competency due to work risk and one of the Indonesia’s government backbone in generating revenue for the country. PT Pertamina Hulu Rokan Zona XXX is one of PT Pertamina (Persero) business subsidiary focusing on exploration and exploitation of oil in gas within Sumatra island. PT Pertamina Hulu Rokan Zona XXX is responsible in managing oil and gas block from Jambi Province to Nanggroe Aceh Darussalam Province, so that managing human resources is crucial to help the company reach its own target. To reach its target, employee work productivity plays an important role. Variable used to measure employee work productivity is workload, teamwork and job satisfaction. This research aims to analyze the interaction between every variables in employee work productivity on PT Pertamina Hulu Rokan Zona XXX. The result of this study indicate that workload, teamwork and job satisfaction have a significant effect on employee work productivity, where workload giving a negative effect empoloyee work productivity, teamwork and job satisfaction giving positive effect on employee work productivity. Conclusion of this research is that workload giving negative effect and significant on job satisfaction as well as employee work productivity due to high workload with insufficient appreciation from the company causing the job satisfaction decreases which imply on the reduction of employee work productivity. Meanwhile, teamwork giving positive effect and significant on job satisfaction, since increase in teamwork attitude within colleagues will raise employee work productivity on PT Pertamina Hulu Rokan Zona XXX.
Kajian KAJIAN MINAT BELI ULANG SECARA ONLINE PADA GENARASI Z DENGAN PERCEIVED RISK, KEPERCAYAAN, DAN GAYA HIDUP SEBAGAI VARIABEL ANTESEDEN
Authors: Asmoro Anjas Kridho , Nuvriasari Audita
Published: April 2023

This research analyses the effect of perceived risk, trust, and lifestyle towards online repurchase intention on gen z using Shopee as  a marketplace. Sampling technique used purposive sampling and  100 respondents in the research sample in total. Hypothesis result of this research is proven that perceived risk has no significant affect towards online repurchase intention. It refers that perceived risk variable isn't affected to online repurchase intention on gen Z. Hence, the opposite of previous statement, trust and lifestyle have positive influenced and significantly towards online repurchase intention. The higher trust that given and the more gen Z's lifestyle fitted with online purchase behavior in Shopee marketplace, would likely increase online repurchase intention. Determination test results show that perceived risk, trust and lifestyle affected to 51,8% online repurchase intention.
MODERASI PERTUMBUHAN PERUSAHAAN DIANTARA PENGARUH MANAJEMEN MODAL KERJA TERHADAP PROFITABILITAS PADA PERUSAHAAN TERINDEKS LQ45 DI BURSA EFEK INDONESIA
Authors: Rahayu Gita , Halim Edyanus Herman , Kamaliah Kamaliah
Published: April 2023

The information that is often needed by investors is about the company's ability to generate profits which is calculated using the profitability ratio. profitability is the most important determinant of profitability because the main indicator of a company's ability to pay dividends is the company's ability to generate profits. In addition to analyzing profitability ratios, investors also need to consider share ownership by directors or commissioners of the company. This study aims to determine and analyze the effect of working capital turnover, inventory turnover and accounts receivable turnover on profitability. Knowing and analyzing working capital turnover, inventory turnover and accounts receivable turnover on profitability with company growth as a Moderating Variable. In this study, the population is Lq45 companies listed on the Indonesia Stock Exchange in 2016-2020. From the total population, the sample is determined as many as 40 companies. The data used in this study are primary data and secondary data, while the technique of collecting data on the company's financial statements. Data analysis techniques in this research use 2 data analysis methods, namely multiple regression and Moderated Regression Analysis (MRA). Based on the findings of working capital turnover, inventory turnover and accounts receivable turnover have a significant effect on profitability. Company growth is able to moderate the effect of working capital turnover, inventory turnover and accounts receivable turnover on profitability,
PENGARUH PENERAPAN MANAJEMEN RISIKO BISNIS DALAM SMALL BUSINESS DEVELOPMENT PADA WARKOP 96
Authors: Lilis Lilis , Clarissa Novia , Herliani Herliani , Dikson Dikson , Wilson Jhon
Published: April 2023

Warkop96 has a unique concept where food is served with large and attractive portions. At the beginning of the opening of this warkop96 business, consumers were very interested in visiting warkop 96. The purpose of the study was to determine the effect of implementing Business Risk Management in Small Business Development. The methods used are qualitative methods and survey methods. Based on this research, it can be seen that in the strategy planned by Warkop96 there are several risk assessments that must be analyzed by Warkop 96, namely by analyzing the strengths, weaknesses, opportunities, and threats (SWOT).
OPTIMALISASI PENGAMBILAN BARANG DI WAREHOUSE PT. DOK PANTAI LAMONGAN DENGAN SKEMA PERPUTARAN DAN PENYIMPANAN BARANG YANG MENGACU PADAS SISTEM FIFO MENGGUNAKAN TOOLS IDENTIFIKASI PELABELAN BARANG
Authors: Nurdhika Firdaus Ilyas , Himawan Abdurrahman Faris Indriya
Published: April 2023

Warehouse is a place for receiving, temporary storage and inventory of sparepart, material and item will be used for production needs. The storage warehouse must have an affective system for maximum retrieval of goods so that it can produce a good goods circulation diagram and good goods storage scheme. PT Dok Pantai Lamongan is a construction company that focuses on new building and ship repair. The FIFO method is one of the appropriate methods to be applied to find out new goods arriving and old goods so that the goods turnover process will be more effective and efficient. This study aims to find out how the process of picking and storing goods is effective and efficient using the FIFO system which refers to the identification tools for picking up goods at PT Dok Pantai Lamongan. The type of research used is descriptive qualitative research. Data collection was carried out by means of interviews, documentation and observation. The results of this study indicate that using the FIFO system using goods identification tools can speed up the circulation of goods and speed up service at the PT Dok Pantai Lamongan warehouse.
Contribución al conocimiento del género Osmarina Clarke, 1978 (Lepidoptera: Oecophoridae)
Authors: Urra Francisco , Araneda Sebastián
Published: May 2023

Se actualiza la descripción morfológica del género Osmarina Clarke, 1978, se redescribe el macho de la especie tipo, Osmarina argilla Clarke, 1978; y se describe una nueva especie, Osmarina processifera sp. nov., a partir de especímenes recolectados en Colchagua y Curicó, Chile. Se entregan caracteres diagnósticos para ambas especies y fotografías e ilustraciones de las estructuras genitales.
Effect of Giving the Active Ingredient Jellyfish Alkaloids (Bougainvillia sp.) Through Immersion Method on Changes in the Amount of Protein Plasma of Tiger Grouper (Epinephelus fuscoguttatus) Infected with Vibrio harveyi
Authors: Afifah Afifah
Published: May 2023

The purpose of this study was to obtain information regarding the potency of the alkaloid active ingredient in jellyfish (Bougainvillia sp) on the immune response of tiger grouper fry infected with Vibrio harveyi bacteria through the immersion method by observing changes in appearance and the amount of plasma protein in tiger grouper infected with bacteria. V. harveyi. The research results obtained explained that the immunostimulant ingredients from jellyfish alkaloids (Bougainvillia sp.) given by immersion can stimulate non-specific and fish-specific immunity. This is characterized by an increase in the amount of protein found in fish blood plasma after administration of alkaloids. Besides that, it can also be seen that the administration of this alkaloid is able to inhibit the infection power of Vibrio harveyi. It is proven that in fish given alkaloid immunostimulants, the amount of protein that appears can be more and the protein content is also high. With a larger protein, it will be able to further stimulate non-specific immunity so that later various antibodies as specific immunity in fish will also be formed. This research ultimately concludes that jellyfish alkaloids (Bougainvillia sp) can be used as immunostimulants to inhibit bacterial attacks Vibrio harveyi in tiger grouper seeds with the optimal dose through immersion method that can be applied is 10.22 ppm. As a follow-up to the results of this study, it is suggested to carry out further research on the application of immunostimulants using jellyfish alkaloids (Bougainvillia sp.
Response of Growth and Yield of Sweet Corn (Zea mays saccharata Sturt) to Giving Tofu Liquid Waste and Chicken Manure Fertilizer
Authors: Simon Heirin
Published: May 2023

This study aims to determine the response of growth and yield of Sweet corn crops (Zea mays saccharata Sturt) on the provision of liquid waste tofu and chicken manure. This research was arranged by using Randomized Block Design with treatments, namely: Control (P0), liquid waste tofu 300 ml (P1), liquid waste tofu 600 ml (P2), chicken manure (P3), liquid waste tofu 300 ml + chicken manure (P4), liquid waste tofu 600 ml + chicken manure (P5) with 4 replications. The variables observed in this study consist of; plant height, number of leaves, number of cobs, cob weight and wet weight of the plant. Data were analyzed by using variance test (Anova) followed by Duncan 5% test. The results showed that the liquid waste treatment of 600 ml + chicken manure can increase the plant height, the number of leaves, the number of cobs, the weight of the cob and the wet weight of the plant. The best crop yields were found in the treatment of liquid waste of 600 ml + manure (P5) because it was able to increase plant height 61.20%, leaves 40.16%, cobs 79%, cob weight 564,74%, wet weight 163, 83% compared with control treatment (P0).
Growth Response of Oil Palm Seedlings (Elaeis guineensis Jacq) to Administration of Planmate Organic Fertilizer in Main Nurseries
Authors: Gunawan Defa Okta
Published: May 2023

The objective of the experiment was to determine the growth response of oil palm (Elaeis guineensis Jacq) seedlings to the application of planmate organic fertilizer in the main nursery. The experiment used a completely randomized design (CRD) with 5 treatment levels consisting of; P0 = without applying planmate fertilizer, P1 = 300 g per polybag, P2 = 350 g per polybag, P3 = 400 g per polybag, P4 = 450 g per polybag. Each treatment level was repeated 3 (three) times, so that there were experimental units, each plot consisting of 3 (three) polybags of oil palm seeds, so that a total of 45 polybags, all plants were sampled. Parameters observed were soil pH, plant height, seedling stem diameter, plant dry weight, and root dry weight. The results of the study showed that the application of planmate fertilizer had a significant effect on soil pH, plant height, stem diameter, shoot dry weight, and root dry weight. The best dose of planmate fertilizer is 450 g per polybag (P4) to give yields on shoot height, stem diameter, dry weight of plants and dry weight of roots of oil palm seedlings.
A Look at the extrapolated losses due to fire outbreak in Anambra State, Nigeria
Authors: O Aronu, C. , O Bilesanmi A. , T3 Arowolo, O. , R. B Agbogidi,
Published: May 2023

The recent rise in fire incidents in Anambra State has resulted in displacement, stress, psychological, adverse effect on the lives of its inhabitants and a devastating consequence on the economy.  The objectives of the study include examining the estimated value of properties loss due to fire outbreak within the study period and to employ the Random Forest regression model to predict the estimated losses associated with fire disasters in Anambra State. The data for the study was a secondary data obtained from the records Department of the Anambra State Fire Service, Headquarters Awka. The study used the Random Forest regression method to analyze the data obtained in this study. The Random Forest regression analysis was employed to predict the estimated value of properties loss (EVPL) due to fire outbreak. The explanatory variables used for the prediction of the response variable were Number of victims (NV), Percentage of Plain Land (PL), Population Size (PS), Population Density (PD) and Actual Revenue by LGA (ARLGA). The findings of the study revealed that EVPL has a higher Skewness and Kurtosis followed by NV and the least was found to be PL. Further result revealed that the percentage of variance explained was 12.03%, sum of square error (SSE) was 31.41, root mean square error (RMSE) was 0.7236 while the R-square was 59.18%. This result implies that the model was moderately positively adequate since it recorded a positive coefficient of determination. The findings from the variable importance analysis showed that Population Density played a major role in the estimation of the response variable followed by the number of victims while population size was found to be the least important variable for estimating the response variable.
CO Methanation Over SAPO-34 Supported Ni Catalysts
Authors: BALIKÇI DEREKAYA Filiz , KILINÇ Yusuf Serkan
Published: April 2023

This study investigated carbon monoxide methanation with 15 %NiO doped SAPO-34 zeolite-supported catalysts. The SAPO-34 support was produced by hydrothermal synthesis, and nickel oxide was added to the support by impregnation and surfactant-assisted impregnation method, dissolved in different solvents (water, ethanol, acetone, and 1-propanol). Various characterization techniques, N2 physisorption, XRD, SEM, TEM, and FTIR, were used to determine the physical properties of catalysts. XRD analysis showed that synthesizing the catalysts with surfactant reduced the crystallite size. The average crystal sizes of the catalysts synthesized using the impregnation and surfactant-assisted impregnation methods are between 11.3-7.1 nm and 8.9-7.1 nm, respectively. The N2 physisorption analysis showed that the catalysts with the surfactant assisted impregnation method had higher surface areas among the catalysts produced by the two different preparation methods. It was observed that the surface area of the catalyst increased as the boiling point of the solvent increased. Scanning electron microscopy (SEM) analysis exhibited that the particle size of the catalysts with 1-propanol prepared by impregnation and surfactant-assisted impregnation methods are 118 nm and 86 nm, respectively. According to the results, surfactants cause to produce smaller particles. The CO methanation studies showed that the highest CO conversion values were reached with Ni/SAPO-34 catalyst using 1- propanol prepared by impregnation and other method, which gave 19.2% and 21.1% CO conversion to methane at 375C, respectively. The low methane formation rates showed that most of the CO component was adsorbed on the surface, and some were converted to methane.
Bienestar laboral a través de un abordaje estructural de las representaciones sociales: una reflexión sobre su impacto en la salud de los trabajadores
Authors: De Andrade-Tavares Flavia , Farias Diana
Published: April 2023

This article proposed to analyze the social representations of employees of private companies about labor well-being. The methodology used was qualitative, based on a cross-sectional, descriptive study, which used as an instrument a questionnaire with sociodemographic characterization questions and the free word association technique. A prototypical analysis of the social representation of well-being at work was carried out with the help of the IRaMuTeQ software. The use of the theory of social representations made it possible to delve into how workers think about their own well-being at work - BT. It is concluded that BT is influenced by a large number and variety of elements that demonstrate the uniqueness of workers' perceptions, highlighting interpersonal relationships, the appropriate and calm work environment, as well as factors related to performance, personal virtues, health and happiness.