bluuebunny/crossref_metadata_2025 huggingface dataset:
Laryngeal Fracture after Blunt Cervical Trauma in Motorcycle Accident and Its Management
Authors: Ribeiro-Costa Nuno , Carneiro Sousa Pedro , Abreu Pereira Diogo , Azevedo Paula , Duarte Delfim
Published: February 2017

Laryngeal fracture is a rare traumatic injury, potentially fatal, with an estimated incidence of 1 in 30,000 patients admitted to severe trauma centers. Because of the rarity of this injury, physician may be not aware of its existence, leading to a late diagnosis of this entity. We report a case of a 59-year-old woman admitted to the emergency room after a motorcycle accident with cervical trauma. The patient presented with dysphonia, hemoptysis, cervical subcutaneous emphysema, and increasing respiratory distress that led to the intubation of the patient. CT-scan demonstrated displaced fracture of the cricoid and thyroid cartilage. The patient was submitted to tracheostomy and the fracture was surgically repaired. Tracheostomy was removed in third postoperative month. The patient presented a good recovery, reporting only hoarseness but without swallowing or breathing problems at 6-month follow-up.
The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors
Authors: Farren Matthew R. , Hennessey Rebecca C. , Shakya Reena , Elnaggar Omar , Young Gregory , Kendra Kari , Landesman Yosef , Elloul Sivan , Crochiere Marsha , Klebanov Boris , Kashyap Trinayan , Burd Christin E. , Lesinski Gregory B.
Published: February 2017

Selinexor, a selective inhibitor of nuclear export (SINE) compound targeting exportin-1, has previously been shown to inhibit melanoma cell growth in vivo. We hypothesized that combining selinexor with antibodies that block or disrupt T-cell checkpoint molecule signaling would exert superior antimelanoma activity. In vitro, selinexor increased PDCD1 and CTLA4 gene expression in leukocytes and induced CD274 gene expression in human melanoma cell lines. Mice bearing syngeneic B16F10 melanoma tumors demonstrated a significant reduction in tumor growth rate in response to the combination of selinexor and anti-PD-1 or anti-PD-L1 antibodies (P < 0.05). Similar results were obtained in B16F10-bearing mice treated with selinexor combined with anti-CTLA4 antibody. Immunophenotypic analysis of splenocytes by flow cytometry revealed that selinexor alone or in combination with anti-PD-L1 antibody significantly increased the frequency of both natural killer cells (P ≤ 0.050) and CD4+ T cells with a Th1 phenotype (P ≤ 0.050). Further experiments indicated that the antitumor effect of selinexor in combination with anti-PD-1 therapy persisted under an alternative dosing schedule but was lost when selinexor was administered daily. These data indicate that the efficacy of selinexor against melanoma may be enhanced by disrupting immune checkpoint activity. Mol Cancer Ther; 16(3); 417–27. ©2017 AACR.

See related article by Tyler et al., p. 428.
Tumor-Associated Monocytes/Macrophages Impair NK-Cell Function via TGFβ1 in Human Gastric Cancer
Authors: Peng Liu-sheng , Zhang Jin-yu , Teng Yong-sheng , Zhao Yong-liang , Wang Ting-ting , Mao Fang-yuan , Lv Yi-pin , Cheng Ping , Li Wen-hua , Chen Na , Duan Mubing , Chen Weisan , Guo Gang , Zou Quan-ming , Zhuang Yuan
Published: February 2017

Natural killer (NK) cells are a major component of the host antitumor immune response in human cancer. However, the nature, functional regulation, and clinical relevance of NK cells in gastric cancer remain largely unknown. In this study, we showed that the percentages of NK cells in tumors were significantly decreased, and low percentages of tumor-infiltrating NK cells were positively correlated with poor survival and disease progression. Although the expression of activating and inhibitory receptors on NK cells was shown to be not different between tumor and nontumor tissues, NK cells in tumors had impaired effector functions, characterized by decreased IFNγ, TNFα, and Ki-67 expression. We found that tumor-infiltrating monocytes/macrophages were physically close to NK cells, and their percentages negatively correlated with IFNγ+ and TNFα+ NK-cell percentages. Ex vivo study showed that isolated tumor-associated monocytes/macrophages could impair NK-cell expression of IFNγ, TNFα, and Ki-67. Blockade of TGFβ1 attenuated such monocytes/macrophages-mediated impairment of NK-cell function. Our data suggest that human NK-cell function was impaired by tumor-associated monocytes/macrophages, and that restoring NK-cell function may be an important therapeutic strategy to prevent tumor immune escape in gastric cancer. Cancer Immunol Res; 5(3); 248–56. ©2017 AACR.
Acute Ischemic Stroke Therapy Overview
Authors: Catanese Luciana , Tarsia Joseph , Fisher Marc
Published: February 2017

The treatment of acute ischemic stroke has undergone dramatic changes recently subsequent to the demonstrated efficacy of intra-arterial (IA) device-based therapy in multiple trials. The selection of patients for both intravenous and IA therapy is based on timely imaging with either computed tomography or magnetic resonance imaging, and if IA therapy is considered noninvasive, angiography with one of these modalities is necessary to document a large-vessel occlusion amenable for intervention. More advanced computed tomography and magnetic resonance imaging studies are available that can be used to identify a small ischemic core and ischemic penumbra, and this information will contribute increasingly in treatment decisions as the therapeutic time window is lengthened. Intravenous thrombolysis with tissue-type plasminogen activator remains the mainstay of acute stroke therapy within the initial 4.5 hours after stroke onset, despite the lack of Food and Drug Administration approval in the 3- to 4.5-hour time window. In patients with proximal, large-vessel occlusions, IA device-based treatment should be initiated in patients with small/moderate-sized ischemic cores who can be treated within 6 hours of stroke onset. The organization and implementation of regional stroke care systems will be needed to treat as many eligible patients as expeditiously as possible. Novel treatment paradigms can be envisioned combining neuroprotection with IA device treatment to potentially increase the number of patients who can be treated despite long transport times and to ameliorate the consequences of reperfusion injury. Acute stroke treatment has entered a golden age, and many additional advances can be anticipated.
National Trends in Atrial Fibrillation Hospitalization, Readmission, and Mortality for Medicare Beneficiaries, 1999–2013
Authors: Freeman James V. , Wang Yun , Akar Joseph , Desai Nihar , Krumholz Harlan
Published: February 2017

Background:

Data are lacking on national trends for atrial fibrillation (AF) hospitalization, particularly with regard to long-term outcomes including readmission and mortality.

Methods:

We studied all Medicare fee-for-service beneficiaries between 1999 and 2013, and we evaluated rates of hospitalization for AF, in-hospital mortality, length of stay, and hospital payments. We then evaluated rates of long-term outcomes, including 30-day readmission, 30-day mortality, and 1-year mortality. To evaluate changes in rates of AF hospitalization and mortality, we used mixed-effects models, adjusting for age, sex, race, and comorbidity. To assess changes in rates of 30-day readmission, we constructed a Cox proportional hazards model adjusting for age, sex, race, and comorbidity.

Results:

Adjusted rates of hospitalization for AF increased by ≈1% per year between 1999 and 2013, and although geographic variation was present, this trend was consistent nationwide. Median hospital length of stay remained unchanged at 3.0 (interquartile range 2.0–5.0) days, but median Medicare inpatient expenditure per beneficiary increased from $2932 (interquartile range $2232–$3870) to $4719 (interquartile range $3124–$7209) per stay. During the same period, the rate of inpatient mortality during AF hospitalization decreased by 4% per year, and the rate of 30-day readmission decreased by 1% per year. The rates of 30-day and 1-year mortality decreased more modestly by 0.4% and 0.26% per year, respectively.

Conclusions:

Between 1999 and 2013, among Medicare fee-for-service beneficiaries, patients were hospitalized more frequently and treated with more costly inpatient therapies such as AF catheter ablation, but this finding was associated with improved outcomes, including lower rates of in-hospital mortality, 30-day readmission, 30-day mortality, and 1-year mortality.
Atrial Fibrillation and Ventricular Arrhythmias
Authors: Gillis Anne M.
Published: February 2017

Sex-specific differences in the epidemiology, pathophysiology, clinical presentation, clinical treatment, and clinical outcomes of atrial fibrillation (AF), sustained ventricular arrhythmias, and sudden cardiac death are recognized. Sex hormones cause differences in cardiac electrophysiological parameters between men and women that may affect the risk for arrhythmias. The incidence and prevalence of AF is lower in women than in men. However, because women live longer and AF prevalence increases with age, the absolute number of women with AF exceeds that of men. Women with AF are more symptomatic, present with more atypical symptoms, and report worse quality of life in comparison with men. Female sex is an independent risk factor for death or stroke attributable to AF. Oral anticoagulation therapy for stroke prevention has similar efficacy for men and women, but older women treated with warfarin have a higher residual risk of stroke in comparison with men. Women with AF are less likely to receive rhythm control antiarrhythmic drug therapy, electric cardioversion, or catheter ablation in comparison with men. The incidence and prevalence of sustained ventricular arrhythmias and sudden cardiac death are lower in women than in men. Women receiving implantable cardioverter defibrillators for primary prevention of sudden cardiac death are less likely to experience sustained ventricular arrhythmias in comparison with men. In contrast, women receiving a cardiac resynchronization therapy implantable cardioverter defibrillator for the treatment of heart failure are more likely to benefit than men. Women are less likely to be referred for implantable cardioverter defibrillator therapy despite current guideline recommendations. Women are more likely to experience a significant complication related to implantable cardioverter defibrillator implantation in comparison with men. Whether sex differences in treatment decisions reflect patient preferences or treatment biases requires further study.
Abstract of “Cognitive Innovation: A View from the Bridge”
Authors: Denham Susan L. , Punt Michael
Published: February 2017

The paper abstracted here is about creativity. It proceeds from an understanding of the promise of the concept of cognitive innovation as a focus for collaboration between the sciences, arts and humanities. The value of the concept in this context lies in its approach to creativity as a boot-strapping cognitive process in which the energies that shape the poem are necessarily indistinguishable from those that shape the poet.
Hope and Worry: Gendered Emotional Geographies of Climate Change in Three Vulnerable U.S. Communities
Authors: du Bray Margaret V. , Wutich Amber , Brewis Alexandra
Published: February 2017

Climate scientists have proposed that many people have not yet felt the results of climate change. This explains, at least in part, why some people are so unmotivated to make changes to mitigate climate change. Yet, a range of studies focused on other types of weather-related anticipated and experienced disasters, such as drought, clearly demonstrate that climate-related phenomena can elicit strong emotional reactions. Using a combination of open-ended interview questions and close-ended survey questions, the authors conducted semistructured interviews in three biophysically vulnerable communities (Mobile, Alabama; Kodiak, Alaska; and Phoenix, Arizona). The relatively high number of respondents who expressed sadness and worry at the possible outcomes of climate change indicates emotional awareness, even among climate change skeptics. The patterns were significantly gendered, with men across the three sites less likely to indicate hope. Results suggest that emotional aspects of climate change might provide an entry point for rallying vulnerable U.S. communities to consider mitigation efforts.
Mastering the devil: A sociological analysis of the practice of a Catholic exorcist
Authors: Giordan Giuseppe , Possamai Adam
Published: February 2017

This study takes the documented growth in the ministry of exorcism within the Catholic Church as a significant challenge to some accounts of secularization. After clarifying how, according to Catholic doctrine, the devil can operate in people’s lives, this study offers a sociological interpretation of exorcism. This interpretation is illustrated and tested by a sociological analysis of data collected, over a period of 10 years, by a well-established Catholic priest in Italy who himself was well trained and well grounded in philosophical analysis. This sociological case study offers fresh insights into the contemporary social significance of exorcism and provides challenges for future research. In the analysis of the data, it was discovered that only 5% of the initial consultations lead to a ritual of exorcism and that a rapprochement with rituals of deliverance is found for the large majority of the cases.
African Indigenous Religion and Its Ancient Model Reflections of Kongo Hierarchical Monotheism
Authors: Luyaluka Kiatezua Lubanzadio
Published: February 2017

The diversity of the African cultures led the scholars to the conclusion of the impossibility of a unique African indigenous religion (AIR); however, this view fails to account for the common spiritual elements found in Africa. Based on these elements, some scholars support the existence of a unique AIR, but these “common elements” are not found in every African culture. This article capitalizes on the scientific monotheism of the Kongo religion, the Bukongo, and its likeness to the solar religion of Egypt to improve the single-AIR approach and show the various AIRs to be results of the devolution of the original unique solar religion kept in the Bukongo. Contrary to the scholastic monotheism, demonstrated to be fallacious, the monotheism of the AIR is proven to be scientific through the use of a cosmological argument whose conclusions are mathematically convergent with Newtonian physics in its interpretation of the movements and stability of bodies at the astronomic and subatomic levels.
Can Hospital Competition Really Affect Hospital Behavior or Not? An Empirical Study of Different Competition Measures Comparison in Taiwan
Authors: Yu Tsung-Hsien , Tung Yu-Chi , Wei Chung-Jen
Published: February 2017

Different approaches to measure the hospital competition index might lead to inconsistent results of the effects of hospital competition on innovation adoption. The purpose of this study is to adopt a different approach to define market area and measure the level of competition to examine whether hospital competition has a positive effect on hospital behavior, taking quality indicator projects participation as an example. A total of 238 hospitals located in Taipei, Taichung, and Kaohsiung were recruited in this study. Competition index was used as the independent variable, and participation lists of Taiwan Clinical Performance Indicator and Taiwan Healthcare Indicator Series in 2012 were used as dependent variables. All data used in this study were retrieved from the 2012 national hospital profiles and the participation list of the 2 quality indicator projects in 2012; these profiles are issued by the Taiwan Ministry of Health and Welfare annually. Geopolitical boundaries and 4 kinds of fixed radiuses were used to define market area. Herfindahl-Hirschman Index and hospital density were used to measure the level of competition. A total of 12 competition indices were produced in this study by employing the geographic information system, while max-rescaled R2 was used to evaluate and compare the models on goodness of fit. The results show that the effects of hospital competition on quality indicator projects participation were varied, which mean different indicators for market competition might reveal different conclusions. Furthermore, this study also found the Herfindahl-Hirschman Index at 5-km radius was the optimum competition index.
Biting Off More Than They Can Chew: Food Waste at Hotel Breakfast Buffets
Authors: Juvan Emil , Grün Bettina , Dolnicar Sara
Published: February 2017

Tourists bite off more than they can chew at hotel breakfast buffets. Food waste from hotel buffets means unnecessary food cost for hotels as well as an unnecessary burden on the environment. The present study measured food waste at a hotel breakfast buffet and identified the following guest and breakfast characteristics as being significantly associated with higher plate waste: more children in the guest mix, more Russians and less Austrians or Germans, fewer hotel guests in the breakfast buffet area as well as more buffet stations being set up. These insights contribute to knowledge on environmental sustainability in tourism, pointing to interesting market segments for targeting in high demand periods as well as promising target segments for interventions (e.g., families) and indicate that simple measures such as rearrangements of the breakfast room may reduce food waste.
A phenomenographic study of factors leading to variation in the experience of a school-based wilderness experiential programme
Authors: Zygmont Conrad Stanisław , Naidoo Anthony V
Published: February 2017

Adventure programming provides an exemplar for interventions through which adolescents may experience holistic development, interdependence, competence, and learn to model pro-social values. This study used a phenomenographic methodology to investigate the different ways in which a sample of 37 adolescents experienced a 27-day school-based wilderness adventure programme and identify aspects of the programme that were critical to variation in programme outcomes. The analysis revealed four conceptions of the programme: (a) long gruelling school hike, (b) school initiation/rite of passage programme, (c) once-in-a-lifetime group adventure, and (d) multifaceted learning and development opportunity. These categories of description are structured hierarchically, relate directly to programme outcomes, and evolve from different levels of awareness in six critical dimensions of variation, including: (a) programme characterisation, (b) the nature of group processes and interactions, (c) the nature and level of connection and interactions with adult group leaders, (d) the depth of engagement in various components of the programme, (e) the personal relevance that experiences had for participants, and (f) the type of growth and learning that was perceived to have accrued from these experiences. These findings and their implications for both adventure programming design and implementation, and for research on psychological interventions are discussed.
On the Attitudinal Consequences of Being Mindful
Authors: Haddock Geoffrey , Foad Colin , Windsor-Shellard Ben , Dummel Sebastian , Adarves-Yorno Inmaculada
Published: February 2017

A series of studies examined whether mindfulness is associated with the experience of attitudinal ambivalence. Studies 1A and 1B found that mindful individuals expressed greater comfort holding ambivalent views and reported feeling ambivalent less often. More mindful individuals also responded more positively to feelings of uncertainty (as assessed in Study 1B). Study 2 replicated these effects and demonstrated that mindful individuals had lower objective and subjective ambivalence across a range of attitude objects but did not differ in attitude valence, extremity, positivity/negativity, strength, or the need to evaluate. Study 3 showed that the link between greater ambivalence and negative affect was buffered by mindfulness, such that there was no link between the amount of ambivalence and negative affect among more mindful individuals. The results are discussed with respect to the benefits of mindfulness in relation to ambivalence and affect.
Assessing the health information source perceptions of tweens using card-sorting exercises
Authors: St. Jean Beth , Greene Taylor Natalie , Kodama Christie , Subramaniam Mega
Published: February 2017

As young people are increasingly turning to the Internet to meet their information needs, it is imperative to investigate their perceptions regarding various potential sources of health information. A series of card-sorting exercises were administered to new participants in an after-school programme (HackHealth) to find out which sources of health information these greater Washington DC metro area middle school students would turn to, which they would not and their reasons behind these judgements. The findings revealed that participants were very aware of the importance of trustworthiness when looking for health information and they valued both professional expertise based on formal education and expertise born of personal experience with a particular health condition. However, they also valued convenience, ease and speed, and sometimes sacrificed information quality. Some important implications of these findings for healthcare and information professionals are identified and suggestions for future research in this area are offered.
Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease
Authors: Miners J Scott , Schulz Isabel , Love Seth
Published: February 2017

Recent studies implicate loss of pericytes in hypoperfusion and blood–brain barrier (BBB) leakage in Alzheimer's disease (AD). In this study, we have measured levels of the pericyte marker, platelet-derived growth factor receptor-β (PDGFRB), and fibrinogen (to assess blood–brain barrier leakage), and analyzed their relationship to indicators of microvessel density (von Willebrand factor level), ante-mortem oxygenation (myelin-associated glycoprotein:proteolipid protein-1 ratio and vascular endothelial growth factor level), Aβ level and plaque load, in precuneus and underlying white matter from 49 AD to 37 control brains. There was reduction in PDGFRB and increased fibrinogen in the precuneus in AD. These changes correlated with reduction in oxygenation and with plaque load. In the underlying white matter, increased fibrinogen correlated with reduced oxygenation, but PDGFRB level was unchanged. The level of platelet-derived growth factor-ββ (PDGF-BB), important for pericyte maintenance, was increased in AD but mainly in the insoluble tissue fraction, correlating with insoluble Aβ level. Loss of the PDGFRB within the precuneus in AD is associated with fibrinogen leakage and reduced oxygenation, and related to fibrillar Aβ accumulation. In contrast, fibrinogen leakage and reduced oxygenation of underlying white matter occur independently of loss of PDGFRB, perhaps secondary to reduced transcortical perfusion.
Effect of pretreatment with midazolam on etomidate-induced myoclonus: A meta-analysis
Authors: Zhou Chengmao , Zhu Yu , Liu Zhen , Ruan Lin
Published: February 2017

Objective

To investigate the effect of pretreatment with midazolam on myoclonus induced by etomidate injection.

Methods

A meta-analysis was performed using Review Manager software, version 5.2. Two researchers independently searched PubMed, Cochrane Library, and Embase® databases for randomized controlled trials involving patients who underwent etomidate induced general anaesthesia with or without midazolam pretreatment, published between 1990 and 2016. Outcome measures comprised overall myoclonus incidence rate and incidence rate classified by degree of myoclonus following etomidate injection. Data were assessed using a fixed effects model.

Results

Five studies, comprising 302 patients, were included for analysis. Overall incidence rate of etomidate injection-induced myoclonus was significantly lower in the pooled midazolam group versus controls (relative risk [RR] 0.34, 95% confidence interval [CI] 0.26, 0.44); Results subgrouped by degree of myoclonus showed significantly lower incidence in midazolam groups versus control groups for mild myoclonus (RR 0.56, 95% CI 0.39, 0.80); moderate myoclonus (RR 0.20, 95% CI 0.10, 0.41); and severe myoclonus (RR 0.12, 95% CI 0.04, 0.39).

Conclusion

Midazolam can effectively prevent etomidate-induced myoclonus, and alleviate the degree of etomidate-induced myoclonus.
Historical Analyses of Disordered Handwriting
Authors: Schiegg Markus , Thorpe Deborah
Published: February 2017

Handwritten texts carry significant information, extending beyond the meaning of their words. Modern neurology, for example, benefits from the interpretation of the graphic features of writing and drawing for the diagnosis and monitoring of diseases and disorders. This article examines how handwriting analysis can be used, and has been used historically, as a methodological tool for the assessment of medical conditions and how this enhances our understanding of historical contexts of writing. We analyze handwritten material, writing tests and letters, from patients in an early 20th-century psychiatric hospital in southern Germany (Irsee/Kaufbeuren). In this institution, early psychiatrists assessed handwriting features, providing us novel insights into the earliest practices of psychiatric handwriting analysis, which can be connected to Berkenkotter’s research on medical admission records. We finally consider the degree to which historical handwriting bears semiotic potential to explain the psychological state and personality of a writer, and how future research in written communication should approach these sources.
The Scope and Autonomy of Personal Narrative
Authors: Ingraham Chris
Published: February 2017

The work of Carol Berkenkotter and others who have expanded the realm of personal narrative studies over the past several decades would not have been possible without the pioneering efforts of those who first brought the study of narrative to nonliterary discourses. By revisiting what personal narratives were to these pioneers—working outward from William Labov in particular—this article considers how the early expansion of the field helps us to understand the far wider expansion of multimodal personal narrative today. In doing so, I suggest that understanding the notion of a personal narrative requires a twofold commitment to inquiry: first, about what makes it narrative; and second, about what makes it personal. These commitments hinge on two crucial junctures, what I call the problem of scope and the problem of autonomy. Framed as questions, the former asks, When does a narrative begin and end? The latter asks, Whose narrative is it? This recuperative essay shows that the heuristics of scope and autonomy can be useful ways to think about the ongoing complexities of personal narrative and its analysis.
Pacific advantage: Wooden shipbuilding in British Columbia, Washington State and Oregon during the First World War
Authors: Madsen Chris
Published: February 2017

This comparative overview assesses physical and cross-border factors behind wartime wooden shipbuilding in North America’s Pacific Northwest. Local resources, government procurement arrangements, private companies running shipyards, and types of workers building standard ships to a variety of designs are considered. Wooden shipbuilding, from a programme perspective, was soundly managed but delivered ships too late to have any real impact on the First World War.
Rural–Urban Disparities in Obesity Prevalence Among Working Age Adults in the United States: Exploring the Mechanisms
Authors: Wen Ming , Fan Jessie X. , Kowaleski-Jones Lori , Wan Neng
Published: February 2017

Purpose:

Higher prevalence rates of overweight and obesity in rural America have been consistently reported, but sources of these disparities are not well known. This study presented patterns and mechanisms of these disparities among working age Americans.

Design:

Cross-sectional study.

Setting:

United States of America.

Participants:

The study included 10 302 participants of the 2003-2008 National Health and Nutrition Examination Survey (NHANES) who were 20 to 64 years old, not pregnant, and with a body mass index ranging from 18.5 to 60.

Measures:

Individual-level data were from NHANES including age, gender, race/ethnicity, immigrant status, education, and family income. The outcomes were prevalence of obesity and prevalence of overweight and obesity combined. Neighborhood data were constructed from the 2000 US Census providing tract-level information on family median income and built environmental features and from the 2006 ESRI ArcGIS 9.3 Data DVD providing tract-level park location information.

Analysis:

Geographic information system (GIS) methods were used to create a measure of spatial distance to local parks capturing park accessibility. Random intercept logistic and ordinal logit regression analyses were performed.

Findings:

Multivariate regression results showed that the odds of obesity was higher in rural areas compared to urban areas (odds ratio = 1.358, P < .001) net of demographic controls and that this gap was largely attributable to individual educational attainment and neighborhood median household income and neighborhood built environmental features. After controlling for these hypothesized mediators, the elevated odds associated with rural residence was reduced by nearly 94% and rendered statistically insignificant.

Conclusions:

In this nationally representative cross-sectional sample, rural–urban obesity disparities were large and explained by rural–urban educational differences at the individual level and economic and built environmental differences at the neighborhood level.
Can Situational Action Theory Explain the Gender Gap in Adolescent Shoplifting? Results From Austria
Authors: Hirtenlehner Helmut , Treiber Kyle
Published: February 2017

Although shoplifting is one of the crimes with the smallest gender gap among all offense types, most studies still conclude that males steal from shops more frequently than females. The roots of the gendered distribution of shoplifting have not yet been satisfactorily explained. This work investigates whether situational action theory (SAT) can account for males’ greater involvement in shoplifting compared to females and if the propensity–exposure interaction that is at the heart of the theory applies to both genders. Results from a large-scale student survey conducted in Austria suggest that SAT generalizes to both genders and that it is well suited to explain why males are more likely to shoplift than females.
Long Journeys Toward Freedom: The Relationship Between Coercive Control and Space for Action—Measurement and Emerging Evidence
Authors: Sharp-Jeffs Nicola , Kelly Liz , Klein Renate
Published: February 2017

We report on the development of, and findings from, two scales measuring coercive control and space for action over a period of 3 years in a sample of 100 women who had accessed domestic violence services. We present statistical evidence to show a significant correlation between coercive control and space for action. However, dealing with violence is not a linear process, and support needs to extend beyond being enabled to separate. The scales advance measurement of women’s experience of coercive control and, through the space for action scale, document their ability to restore agency and freedom in contexts of relative safety.
Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 1—Trees
Authors: Colantonio Sophia , Rivers Jason K.
Published: February 2017

Introduction:

First Nations people have a long history of working with medicinal plants used to treat skin diseases. The purpose was to assess the dermatologic therapeutic potential of western red cedar, white spruce, birch, balsam poplar, and black spruce.

Methods:

Based on expert recommendations, 5 trees were selected that were used in First Nations medicine for cutaneous healing and have potential and/or current application to dermatology today. We searched several databases up to June 12, 2014.

Results:

Western red cedar’s known active principal compound, β-thujaplicin, has been studied in atopic dermatitis. White spruce’s known active principal compound, 7-hydroxymatairesinol, has anti-inflammatory activity, while phase II clinical trials have been completed on a birch bark emulsion for the treatment of actinic keratoses, epidermolysis bullosa, and the healing of split thickness graft donor sites. Balsam poplar has been used clinically as an anti-aging remedy. Black spruce bark contains higher amounts of the anti-oxidant trans-resveratrol than red wine.

Discussion:

North American traditional medicine has identified important botanical agents that are potentially relevant to both cosmetic and medical dermatology. This study is limited by the lack of good quality evidence contributing to the review. The article is limited to 5 trees, a fraction of those used by First Nations with dermatological properties.
Sweet Syndrome: Clinical Features, Histopathology, and Associations of 83 Cases
Authors: Casarin Costa Jose Ricardo , Virgens Anangelica Rodrigues , de Oliveira Mestre Luisa , Dias Natasha Favoretto , Samorano Luciana Paula , Valente Neusa Yuriko Sakai , Festa Neto Cyro
Published: February 2017

Background:

Sweet syndrome (SS) is an infrequent skin disease characterised by sudden onset of fever, leukocytosis, neutrophilia, and tender erythematous plaques infiltrated by neutrophils. Multiple conditions have been associated with this syndrome.

Objectives:

The aim of this study was to evaluate the clinical, epidemiological, laboratory, and histopathological findings and associations of patients with SS.

Methods:

We conducted a retrospective study of 83 patients with SS followed between January 1, 2006, and January 31, 2015.

Results:

Of the patients, 82% were female; the mean age at onset was 48 years. Clinical presentation was mainly characterised by erythematous and edematous plaques, mostly on upper extremities and trunk. Fever was observed in 32%; 60% presented leukocytosis and 39% neutrophilia. On histopathological examination, neutrophilic and lymphohistiocytic infiltrate and edema were the most frequent findings. Fourteen percent of patients had malignancy or hematologic disorders, 26% were classified as having drug-induced SS, and 24% noted recent infection. Only 2 cases occurred during pregnancy. Systemic corticosteroid was the most common choice of treatment, with excellent response. In malignancy-associated SS, the mean hemoglobin level was lower ( P = .01) and the erythrocyte sedimentation rate (ESR) was higher ( P = .04) in comparison to classic and drug-induced SS. Leukocytoclasia was associated with higher risk of recurrence ( P = .01).

Conclusion:

All patients with SS deserve careful investigation of possible underlying conditions. Higher ESR and lower hemoglobin levels might reinforce the need of malignancy screening. Also, leukocytoclasia appears to be a potential marker of higher recurrence rate, demanding closer and longer follow-up.
Comparison of Computed Tomography Articular Surface Geometry of Male Versus Female Thumb Carpometacarpal Joints
Authors: Shih Jessica G. , Mainprize James G. , Binhammer Paul A.
Published: February 2017

Background: Given the predilection of first carpometacarpal (CMC) joint osteoarthritis in women compared with men, we aim to determine the differences in first CMC joint surface geometry and congruence between young healthy males and females. Methods: Wrist computed tomographic scan data of 11 men and 11 women aged 20 to 35 years were imported into 3-dimensional software programs. The first metacarpal and the trapezium were aligned in a standardized position according to landmarks at key points on Gaussian and maximum curvature maps. Measurements of joint congruence and surface geometry were analyzed, including joint space volume, distance between the bones at the articular surface edges, area of the joint space, and radii of curvature in the radial-ulnar and volar-dorsal planes. Results: The mean thumb CMC articular space volume was 104.02 ± 30.96 mm3 for females and 138.63 ± 50.36 mm3 for males. The mean first metacarpal articular surface area was 144.9 ± 10.9 mm2 for females and 175.4 ± 25.3 mm2 for males. After normalizing for size, the mean thumb CMC articular space volume was 119.4 ± 24.6 mm3 for females and 117.86 ± 28.5 mm3 for males. There was also no significant difference for the articular space volume, articular surface distances, articular space, and mean radii of curvatures. Conclusions: This study found that there are sex differences in the first CMC joint articular volume without normalizing for size; however, there are no sex differences in first CMC joint articular volume, curvature characteristics, or joint congruence of young, healthy patients after normalizing for joint size.
Seroreactivity to Anisakis spp. in the perinatal period
Authors: Santos Luciana , Vericimo Mauricio , Teixeira Gerlinde , Clemente Sergio S , Figueiredo Israel
Published: February 2017

Background

This study had sought to assess the seroreactivity to the fish nematode Anisakis spp. in a puerperal population, as well as to ascertain whether a correlation exists between maternal and cord blood levels.

Methods

Blood samples were obtained from puerperal women and cord blood to measure specific anti- Anisakis antigen IgG and IgE by ELISA. Non-parametric tests were used to compare two or more independent and related samples.

Results

Of the 99 maternal serum samples assessed, 21 were positive on ELISA (21.2%). There were no significant differences in the mean ranks of IgG optical density levels between women who ate fish and those who did not (p = 0.456), those who ate raw fish and those who did not (p = 0.479), or between those who had allergic complaints and those who did not (p = 0.431).

Conclusion

Transplacental passage of antibodies occurred, leading to moderate correlation between maternal and cord blood serum levels.
Visualization of vortical flows around a rapidly pitching wing and propeller
Authors: Su Erlong , Randall Ryan , Wilson Lee , Shkarayev Sergey
Published: February 2017

This study was conducted to visually investigate flows related to fixed-wing vertical-takeoff-and-landing micro air vehicles, using the smoke-wire technique. In particular, the study examines transition between forward flight and near-hover. The experimental model consists of a rigid Zimmerman wing and a propulsion system with contra-rotating propellers arranged in a tractor configuration. The model was pitched about the wing’s aerodynamic center at approximately constant rates using a five-axis robotic arm. Constant-rate pitching angles spanned 20° to 70°. No-pitching and four pitching-rates were used, along with three propulsive settings. Several observations were made during no-pitching tests. Turbulent wakes behind blades and laminar flow between them produces pulsations in the boundary layer. These pulsations alter the boundary layer from a laminar to turbulent state and back. An increase in lift and drag in the presence of a slipstream is a result of competing effects of the propulsive slipstream: (a) suppression of flow separation and increased velocity over the wing and (b) decrease of the effective angle of attack. Higher nose-up pitching-rates generally lead to greater trailing-edge vortex-shedding frequency. Nose-up pitching without a slipstream can lead to the development of a traditional dynamic-stall leading-edge vortex, delaying stall and increasing wing lift. During nose-up pitching, a slipstream can drive periodically shed leading-edge vortices into a larger vortical-structure that circulates over the upper-surface of a wing in a fashion similar to that of a traditional dynamic-stall leading-edge vortex. At lower nose-up pitching-rates, leading-edge vortices form at lower angles of attacks. As a slipstream strengthens, a few things occur: separation wakes diminish, separation occurs at a higher angle of attacks, and downward flow-deflection increases. Similar effects are observed for nose-up pitching, while nose-down pitching produces the opposite effects.
Spontaneous resolution of ruptured intracranial pial arteriovenous fistula following spinal surgery
Authors: Lyons Mark K , Hoxworth Joseph M , McClendon Jamal , Krishna Chandan X , Patel Naresh P
Published: February 2017

Pial arteriovenous fistulae (AVFs) are rare vascular abnormalities that are distinct from arteriovenous malformations and dural AVFs. These vascular lesions have been linked with trauma, ischemic syndromes, venous thrombotic diseases, and intracranial surgical procedures. In this report we describe a case of an intracranial ruptured pial AVF immediately following uneventful spinal surgery in an elderly patient with subsequent spontaneous resolution. He was a previous heavy smoker with a 60-pack-year history and alcohol abuse. His examination was positive for morbid obesity and mild weakness of the anterior tibialis and gastrocnemius muscles bilaterally. He underwent uneventful spinal surgery, suffering a generalized seizure shortly after extubation. Imaging studies demonstrated acute subarachnoid hemorrhage and cerebral angiography identified a pial AVF. He was stabilized medically and follow-up angiography demonstrated spontaneous resolution of the pial AVF. This case highlights a rare vascular malformation with rupture following uneventful spinal surgery.
Exploring diurnal variation using piecewise linear splines: an example using blood pressure
Authors: Madden Jamie M. , Li Xia , Kearney Patricia M. , Tilling Kate , Fitzgerald Anthony P.
Published: February 2017

Background

There are many examples of physiological processes that follow a circadian cycle and researchers are interested in alternative methods to illustrate and quantify this diurnal variation. Circadian blood pressure (BP) deserves additional attention given uncertainty relating to the prognostic significance of BP variability in relation to cardiovascular disease. However, the majority of studies exploring variability in ambulatory blood pressure monitoring (ABPM) collapse the data into single readings ignoring the temporal nature of the data. Advanced statistical techniques are required to explore complete variation over 24 h.

Methods

We use piecewise linear splines in a mixed-effects model with a constraint to ensure periodicity as a novel application for modelling daily blood pressure. Data from the Mitchelstown Study, a cross-sectional study of Irish adults aged 47–73 years (n = 2047) was utilized. A subsample (1207) underwent 24-h ABPM. We compared patterns between those with and without evidence of subclinical target organ damage (microalbuminuria).

Results

We were able to quantify the steepest rise and fall in SBP, which occurred just after waking (2.23 mmHg/30 min) and immediately after falling asleep (−1.93 mmHg/30 min) respectively. The variation about an individual’s trajectory over 24 h was 12.3 mmHg (standard deviation). On average those with microalbuminuria were found to have significantly higher SBP (7.6 mmHg, 95% CI 5.0–10.1) after adjustment for age, sex and BMI. Including an interaction term between each linear spline and microalbuminuria did not improve model fit.

Conclusion

We have introduced a practical method for the analysis of ABPM where we can determine the rate of increase or decrease for different periods of the day. This may be particularly useful in examining chronotherapy effects of antihypertensive medication. It offers new measures of short-term BP variability as we can quantify the variation about an individual’s trajectory but also allows examination of the variation in slopes between individuals (random-effects).
Complete genome sequence of Pseudoalteromonas phage vB_PspS-H40/1 (formerly H40/1) that infects Pseudoalteromonas sp. strain H40 and is used as biological tracer in hydrological transport studies
Authors: Kallies René , Kiesel Bärbel , Schmidt Matthias , Kacza Johannes , Ghanem Nawras , Narr Anja , Zopfi Jakob , Wick Lukas Y. , Hackermüller Jörg , Harms Hauke , Chatzinotas Antonis
Published: February 2017

Pseudoalteromonas phage vB_PspS-H40/1 is a lytic phage that infects Pseudoalteromonas sp. strain H40. Both, the phage and its host were isolated in the 1970s from seawater samples collected from the North Sea near the island of Helgoland, Germany. The phage particle has an icosahedral capsid with a diameter of ~43 to 45 nm and a long non-contractile tail of ~68 nm in length, a typical morphology for members of the Siphoviridae family. The linear dsDNA genome of Pseudoalteromonas phage vB_PspS-H40/1 has a sequence length of 45,306 bp and a GC content of 40.6%. The genome has a modular structure and contains a high proportion of sequence information for hypothetical proteins, typically seen in phage genome sequences. This is the first report of the complete genome sequence of this lytic phage, which has been frequently used since the 1990s as biological tracer in hydrogeological transport studies.
No Price Like Home: Global House Prices, 1870–2012
Authors: Knoll Katharina , Schularick Moritz , Steger Thomas
Published: February 2017

How have house prices evolved over the long run? This paper presents annual house prices for 14 advanced economies since 1870. We show that real house prices stayed constant from the nineteenth to the mid-twentieth century, but rose strongly and with substantial cross-country variation in the second half of the twentieth century. Land prices, not replacement costs, are the key to understanding the trajectory of house prices. Rising land prices explain about 80 percent of the global house price boom that has taken place since World War II. Our findings have implications for the evolution of wealth-to-income ratios, the growth effects of agglomeration, and the price elasticity of housing supply. (JEL C43, N10, N90, R31)
The Impact of Family Income on Child Achievement: Evidence from the Earned Income Tax Credit: Comment
Authors: Lundstrom Samuel
Published: February 2017

In a recent article in the American Economic Review, Dahl and Lochner (2012) use changes in the Earned Income Tax Credit to estimate the causal effect of family income on child achievement. Their instrumental variable (IV ) estimates imply that a $1,000 increase in income raises combined math and reading test scores by about 6 percent of a standard deviation. I document a variable coding error. Correcting this error reduces the IV estimates by 32 percent; correcting this error does not change the qualitative conclusions of the study. (JEL H24, H31, I21, I38, J13)
Correlation between auroral activity and rate of development of a storm in its main phase
Authors: Бороев Роман , Boroev Roman
Published: February 2017

We investigated the relationship between the rate of storm development in its main phase (|ΔDst|/ΔT) and the average value (ΣAE/ΔT) of AE index for the main phase where |ΔDst| is the Dst-index variation, ΣAE is the total value of AE index for the main phase of magnetic storm, ΔT is the main phase duration. We considered storms initiated by corotating interaction region (CIR) and interplanetary coronal mass ejection (ICME) (magnetic cloud and ejecta). For CIR events, the value of ΣAE/ΔT is shown to correlate with the rate of storm development in its main phase in contrast to the storms initiated by the ICME. As found, there is a weak correlation between ΣAE/ΔT and the minimum value of Dst index for CIR and ICME events.