bluuebunny/crossref_metadata_2025 huggingface dataset:
Imaging of Increasing Damage in Steel Plates Using Lamb Waves and Ultrasound Computed Tomography
Authors: Zielińska Monika , Rucka Magdalena
Published: September 2021

This paper concerns the inspection of steel plates, with particular emphasis on the assessment of increasing damage. Non-destructive tests were performed on four plates, one of which was undamaged, while the remaining three had defects in the form of circular holes with diameters of 2, 5 and 10 cm. Guided Lamb waves were used in the research, and the image reconstruction was performed using ultrasound computed tomography. The damage size was estimated by tracking the real course of rays and densifying the pixel grid into which the object was divided. The results showed the great potential of ultrasound tomography in detecting defects in steel elements, together with the possibility of estimating damage size.
Methane and Carbon Dioxide Hydrate Formation and Dissociation in Presence of a Pure Quartz Porous Framework Impregnated with CuSn12 Metallic Powder: An Experimental Report
Authors: Gambelli Alberto Maria , Stornelli Giulia , Di Schino Andrea , Rossi Federico
Published: September 2021

Hydrate formation and dissociation processes were carried out in the presence of a pure quartz porous medium impregnated with a metallic powder made with a CuSn12 alloy. Experiments were firstly made in the absence of that powder; then, different concentrations were added to the porous medium: 4.23 wt.%, 18.01 wt.%, and 30.66 wt.%. Then, the hydrate dissociation values were compared with those present in the literature. The porous medium was found to act as an inhibitor in the presence of carbon dioxide, while it did not alter methane hydrate, whose formation proceeded similarly to the ideal trend. The addition of CuSn12 promoted the process significantly. In particular, in concentrations of up to 18.01 wt.%, CO2 hydrate formed at milder conditions until it moved below the ideal equilibrium curve. For methane, the addition of 30.66 wt.% of powder significantly reduced the pressure required to form hydrate, but in every case, dissociation values remained below the ideal equilibrium curve.
Peculiar Porous Aluminum Oxide Films Produced via Electrochemical Anodizing in Malonic Acid Solution with Arsenazo-I Additive
Authors: Poznyak Alexander , Knörnschild Gerhard , Karoza Anatoly , Norek Małgorzata , Pligovka Andrei
Published: September 2021

The influence of arsenazo-I additive on electrochemical anodizing of pure aluminum foil in malonic acid was studied. Aluminum dissolution increased with increasing arsenazo-I concentration. The addition of arsenazo-I also led to an increase in the volume expansion factor up to 2.3 due to the incorporation of organic compounds and an increased number of hydroxyl groups in the porous aluminum oxide film. At a current density of 15 mA·cm−2 and an arsenazo-I concentration 3.5 g·L−1, the carbon content in the anodic alumina of 49 at. % was achieved. An increase in the current density and concentration of arsenazo-I caused the formation of an arsenic-containing compound with the formula Na1,5Al2(OH)4,5(AsO4)3·7H2O in the porous aluminum oxide film phase. These film modifications cause a higher number of defects and, thus, increase the ionic conductivity, leading to a reduced electric field in galvanostatic anodizing tests. A self-adjusting growth mechanism, which leads to a higher degree of self-ordering in the arsenazo-free electrolyte, is not operative under the same conditions when arsenazo-I is added. Instead, a dielectric breakdown mechanism was observed, which caused the disordered porous aluminum oxide film structure.
High-Temperature Corrosion of APS- and HVOF-Coated Nickel-Based Super Alloy under Air Oxidation and Melted Salt Domains
Authors: Alnaser Ibrahim A. , Yunus Mohammed , Alfattani Rami , Alamro Turki
Published: September 2021

Various thermal spraying approaches, such as air/atmospheric plasma spraying (APS) and high-velocity oxy-fuel (HVOF) spraying, are widely employed by plants owing to their flexibility, low costs and the high surface quality of the manufactured product. This study focuses on the corrosion behavior of a Ni superalloy coated with powder Cr3C2-25NiCr through APS and HVOF at 950 °C under air oxidation and Na2SO4 + 0.6V2O5 molten salt environments (MSE). The results show that HVOF-deposited Ni superalloys have higher hardness and bond strength than the respective APS coating. The thermo-gravimetric probe reveals that the Ni superalloys exposed to an oxidizing air environment has a minor mass gain compared to those under the MSE domain for both non-coated and coated samples, in line with the parabola curvature rate oxidizing law. The Ni superalloys show good corrosion resistance but poor oxidation resistance in APS-deposited Ni superalloys under the MSE. HVOF-coated Ni superalloys in both environments exhibit better corrosion resistance and lower mass gain than APS-coated superalloys. The excellent coating characteristics of HVOF-coated Ni superalloys lead to their better high-temperature corrosion performance than APS.
Particle Deposition in Drying Porous Media
Authors: Keita Emmanuel
Published: September 2021

The drying of porous media is a ubiquitous phenomenon in soils and building materials. The fluid often contains suspended particles. Particle deposition may modify significantly the final material, as it could be pollutants or clogging the pores, decreasing the porosity, such as in salt, in which particles and drying kinetics are coupled. Here, we used SEM and X-ray microtomography to investigate the dried porous media initially saturated by nanoparticle suspensions. As the suspensions were dried, nanoparticles formed a solid deposit, which added to the initial solid matrix and decreased the porosity. We demonstrate that since the drying occurred through the top surface, the deposit is not uniform as a function of depth. Indeed, the particles were advected by the liquid flow toward the evaporative surface; the deposit was significant over a depth that depended on the initial volume fraction, but the pore size was affected over a very narrow length. These findings were interpreted in the frame of a physical model. This study may help to design better porous media and take into account particle influence in drying processes.
Base Plate Preheating Effect on Microstructure of 316L Stainless Steel Single Track Deposition by Directed Energy Deposition
Authors: Kiran Abhilash , Koukolíková Martina , Vavřík Jaroslav , Urbánek Miroslav , Džugan Jan
Published: September 2021

The microstructural morphology in additive manufacturing (AM) has a significant influence on the building structure. High-energy concentric heat source scanning leads to rapid heating and cooling during material deposition. This results in a unique microstructure. The size and morphology of the microstructure have a strong directionality, which depends on laser power, scanning rate, melt pool fluid dynamics, and material thermal properties, etc. The grain structure significantly affects its resistance to solidification cracking and mechanical properties. Microstructure control is challenging for AM considering multiple process parameters. A preheating base plate has a significant influence on residual stress, defect-free AM structure, and it also minimizes thermal mismatch during the deposition. In the present work, a simple single track deposition experiment was designed to analyze base plate preheating on microstructure. The microstructural evolution at different preheating temperatures was studied in detail, keeping process parameters constant. The base plate was heated uniformly from an external heating source and set the stable desired temperature on the surface of the base plate before deposition. A single track was deposited on the base plate at room temperature and preheating temperatures of 200 °C, 300 °C, 400 °C, and 500 °C. Subsequently, the resulting microstructural morphologies were analyzed and compared. The microstructure was evaluated using electron backscattered diffraction (EBSD) imaging in the transverse and longitudinal sections. An increase in grain size area fraction was observed as the preheating temperature increased. Base plate preheating did not show influence on grain boundary misorientation. An increase in the deposition depth was noticed for higher base plate preheating temperatures. The results were convincing that grain morphology and columnar grain orientation can be tailored by base plate preheating.
Factors Influencing the Load-Bearing Capacity of Rock as Base Material for Post-Installed Anchors
Authors: Lamplmair Stefan , Zeman Oliver , Voit Klaus
Published: September 2021

In the case of fastenings on rock, as a result of the variability, it is quite difficult to make a preliminary assessment of the load-bearing capacity of rock as a base material. This paper therefore investigates which rock parameters next to an anchor position have an influence on the load-bearing capacity. For this purpose, tests are carried out on post-installed anchors in different lithologies in eastern Austria. It can be shown that the joint weathering has an influence on the load-bearing capacity of post-installed anchors and conclusions can be made about joint weathering by means of rebound hammer. Rebound values can therefore also be used to draw conclusions about the rock quality as a base material for post-installed anchors. Nevertheless, a combined optical assessment of the base material is recommended as an adequate method.
Bioinspired Helicoidal Composite Structure Featuring Functionally Graded Variable Ply Pitch
Authors: Meo Michele , Rizzo Francesco , Portus Mark , Pinto Fulvio
Published: September 2021

Composite laminated materials have been largely implemented in advanced applications due to the high tailorability of their mechanical performance and low weight. However, due to their low resistance against out-of-plane loading, they are prone to generate damage as a consequence of an impact event, leading to the loss of mechanical properties and eventually to the catastrophic failure of the entire structure. In order to overcome this issue, the high tailorability can be exploited to replicate complex biological structures that are naturally optimised to withstand extreme impact loading. Bioinspired helicoidal laminates have been already studied in-depth with good results; however, they have been manufactured by applying a constant pitch rotation between each consecutive ply. This is in contrast to that observed in biological structures where the pitch rotation is not constant along the thickness, but gradually increases from the outer shell to the inner core in order to optimise energy absorption and stress distribution. Based on this concept, Functionally Graded Pitch (FGP) laminated composites were designed and manufactured in order to improve the impact resistance relative to a benchmark laminate, exploiting the tough nature of helicoidal structures with variable rotation angles. To the authors’ knowledge, this is one of the first attempts to fully reproduce the helicoidal arrangement found in nature using a mathematically scaled form of the triangular sequence to define the lamination layup. Samples were subject to three-point bending and tested under Low Velocity Impact (LVI) conditions at 15 J and 25 J impact energies and ultrasonic testing was used to evaluate the damaged area. Flexural After Impact (FAI) tests were used to evaluate the post-impact residual energy to confirm the superior impact resistance offered by these bioinspired structures. Vast improvements in impact behaviour were observed in the FGP laminates over the benchmark, with an average reduction of 41% of the damaged area and an increase in post-impact residual energy of 111%. The absorbed energy was similarly reduced (−44%), and greater mechanical strength (+21%) and elastic energy capacity (+78%) were demonstrated in the three-point bending test.
Progressive Collapse Safety Evaluation of Truss Structures Considering Material Plasticity
Authors: Fang Sheng-En , Wu Chen , Zhang Xiao-Hua , Zhang Li-Sen , Wang Zhi-Bin , Zeng Qing-Yi
Published: September 2021

Theoretical or numerical progressive collapse analysis is necessary for important civil structures in case of unforeseen accidents. However, currently, most analytical research is carried out under the assumption of material elasticity for problem simplification, leading to the deviation of analysis results from actual situations. On this account, a progressive collapse analysis procedure for truss structures is proposed, based on the assumption of elastoplastic materials. A plastic importance coefficient was defined to express the importance of truss members in the entire system. The plastic deformations of members were involved in the construction of local and global stiffness matrices. The conceptual removal of a member was adopted, and the impact of the member loss on the truss system was quantified by bearing capacity coefficients, which were subsequently used to calculate the plastic importance coefficients. The member failure occurred when its bearing capacity arrived at the ultimate value, instead of the elastic limit. The extra bearing capacity was embodied by additional virtual loads. The progressive collapse analysis was performed by iterations until the truss became a geometrically unstable system. After that, the critical progressive collapse path inside the truss system was found according to the failure sequence of the members. Lastly, the proposed method was verified against both analytical and experimental truss structures. The critical progressive collapse path of the experimental truss was found by the failure sequence of damaged members. The experimental observation agreed well with the corresponding analytical scenario, proving the method feasibility.
Effects of Insertion of Ag Mid-Layers on Laser Direct Ablation of Transparent Conductive ITO/Ag/ITO Multilayers: Role of Effective Absorption and Focusing of Photothermal Energy
Authors: Choi Younggon , Kim Hong-Seok , Lee Haunmin , Choi Wonjoon , Kwon Sang Jik , Han Jae-Hee , Cho Eou-Sik
Published: September 2021

From the viewpoint of the device performance, the fabrication and patterning of oxide–metal–oxide (OMO) multilayers (MLs) as transparent conductive oxide electrodes with a high figure of merit have been extensively investigated for diverse optoelectronic and energy device applications, although the issues of their general concerns about possible shortcomings, such as a more complicated fabrication process with increasing cost, still remain. However, the underlying mechanism by which a thin metal mid-layer affects the overall performance of prepatterned OMO ML electrodes has not been fully elucidated. In this study, indium tin oxide (ITO)/silver (Ag)/ITO MLs are fabricated using an in-line sputtering method for different Ag thicknesses on glass substrates. Subsequently, a Q-switched diode-pumped neodymium-doped yttrium vanadate (Nd:YVO4, λ = 1064 nm) laser is employed for the direct ablation of the ITO/Ag/ITO ML films to pattern ITO/Ag/ITO ML electrodes. Analysis of the laser-patterned results indicate that the ITO/Ag/ITO ML films exhibit wider ablation widths and lower ablation thresholds than ITO single layer (SL) films. However, the dependence of Ag thickness on the laser patterning results of the ITO/Ag/ITO MLs is not observed, despite the difference in their absorption coefficients. The results show that the laser direct patterning of ITO/Ag/ITO MLs is primarily affected by rapid thermal heating, melting, and vaporization of the inserted Ag mid-layer, which has considerably higher thermal conductivity and absorption coefficients than the ITO layers. Simulation reveals the importance of the Ag mid-layer in the effective absorption and focusing of photothermal energy, thereby supporting the experimental observations. The laser-patterned ITO/Ag/ITO ML electrodes indicate a comparable optical transmittance, a higher electrical current density, and a lower resistance compared with the ITO SL electrode.
Experimental Study on Consolidation-Creep Behavior of Subgrade Modified Soil in Seasonally Frozen Areas
Authors: Wang Fuyu , Pang Weichen , Li Ziqi , Wei Haibin , Han Leilei
Published: September 2021

Frost heaving and boiling are the most common road disorders due to the special climatic conditions in a seasonal frozen area. From the perspective of controlling road disorders in seasonally frozen areas and making effective use of industrial waste residue, two kinds of subgrade modified soil—crumb rubber modified fly ash soil (CRFS) and oil shale waste residue modified fly ash soil (OSFS)—were proposed by the research group. The research results proved that the two new subgrade fillers both have excellent engineering characteristics in cold areas, such as high strength and low thermal conductivity, and both have the function of waste utilization, giving them broad application prospects. In road engineering, the instability of slopes and retaining walls and the uneven settlement of the subgrade are closely related to soil creep, which are problems that cannot be ignored in road design and use. As a new material to treat road disorders in seasonally frozen areas, more attention should be paid to the continuous deformation property of modified soil under long-term load. The study on the creep characteristics of the modified soil can provide reliable parameters for the design of the modified soil subgrade and predict the settlement of the subgrade after construction, which is of great significance to the stability of the subgrade. In this paper, an experimental study on the consolidation–creep characteristics of two kinds of subgrade modified soil in a seasonal frozen region was carried out, the relationship between modified soil deformation and time is discussed, and the effects of different moisture contents and compaction degrees on the creep characteristics of modified soil were analyzed. The test results provide parameters for the engineering design of modified soil subgrade and provide data support for the popularization and application of modified soil in seasonally frozen subgrade.
Fusaripyridines A and B; Highly Oxygenated Antimicrobial Alkaloid Dimers Featuring an Unprecedented 1,4-Bis(2-hydroxy-1,2-dihydropyridin-2-yl)butane-2,3-dione Core from the Marine Fungus Fusarium sp. LY019
Authors: Shaala Lamiaa A. , Alzughaibi Torki , Genta-Jouve Grégory , Youssef Diaa T. A.
Published: September 2021

The fungal strain, Fusarium sp. LY019, was obtained from the Red Sea sponge Suberea mollis. Bioassay-directed partition of the antimicrobial fraction of the extract of the culture of the fungus provided two dimeric alkaloids, fusaripyridines A and B (1 and 2). The compounds possess a previously unreported moiety, 1,4-bis(2-hydroxy-1,2-dihydropyridin-2-yl)butane-2,3-dione. Further, the compounds display a highly oxygenated substitution pattern on the dihydropyridine moieties, representing an additional feature of the fusaripyridines. Fusaripyridines A and B are the first examples of natural products possessing 1,4-bis(2-hydroxy-1,2-dihydropyridin-2-yl)butane-2,3-dione backbone. Careful analyses of the one- and two-dimensional NMR and HRESIMS spectra of the compounds secured their structural mapping, while their absolute stereochemistry was established by analyses of their ECD spectra. The production of such dimeric alkaloids with an unprecedented moiety in the culture of Fusarium sp. LY019 supports further understanding of the biosynthetic competences of the cultured marine-derived fungi. Fusaripyridines A and B selectively inhibited the growth of Candida albicans with MIC values down to 8.0 µM, while they are moderately active against S. aureus, E. coli and HeLa cells.
The Effect of pH on Atenolol/Nanofiltration Membranes Affinity
Authors: Soares Elisa Veridiani , Giacobbo Alexandre , Rodrigues Marco Antônio Siqueira , de Pinho Maria Norberta , Bernardes Andréa Moura
Published: September 2021

Nanofiltration has been shown to be effective in removing pharmaceutical compounds from water and wastewater, so different mechanisms can influence treatment performance. In the present work, we carried out a case study evaluating the performance of two nanofiltration membranes in the removal of Atenolol (ATN)—a pharmaceutical compound widely used for the treatment of arterial hypertension—under different conditions such as operating pressure, ATN concentration, and solution pH. By determining the B parameter, which quantifies the solute/membrane affinity, we verified that the solution pH influenced the performance of the membranes, promoting attraction or repulsion between the ATN and the membranes. At pH 2.5, both membranes and ATN were positively charged, causing electrostatic repulsion, showing lower values of the B parameter and, consequently, higher ATN rejections. At such a pH, the mean ATN rejection for the loose membrane (NF270) was 82%, while for the tight membrane (NF90) it was 88%. On the other hand, at 12 bar pressure, the NF70 membrane (5.1 × 10 −5 m s−1) presented mean permeate fluxes about 2.8 times greater than the NF90 membrane (1.8 × 10−5 m s−1), indicating that NF270 is the most suitable membrane for this application.
Deformation-Induced Grain-Interior α Precipitation and β Texture Evolution during the β-Processed Forging of a Near-β Titanium Alloy
Authors: Kitashima Tomonori , Meng Lingjian , Watanabe Makoto
Published: September 2021

The effect of grain-interior α precipitation on the β texture evolution of the near-β Ti-6246 alloy during through-transus forging was investigated in two-step sequential forgings. The microstructure and texture were analyzed using scanning electron microscopy, electron-backscatter diffraction, and X-ray diffraction. The previous β forging was performed at 1253 K at 0.01/s, while the subsequent forging in the (α + β) region was conducted at 1073 K at 0.01/s. The forging in the β region facilitated the penetration of the interior α phase into β grains and reduced the formation of grain boundary α. The {001} texture intensity increased during the forging in the single β region. By contrast, the increase in the {001} texture intensity was moderate at a lower temperature (1073 K) because the Schmid factor (SF) value of the {110}<111> slip system drastically decreased, but those of the {112}<111> and {123}<111> slip systems increased before α precipitation. During α precipitation for all β forging ratios, the {110}<111> slip system was activated, resulting in a lowering of the {001} texture intensity. The lower the forging temperature before interior α precipitation under a constant total forging ratio, the more the {001} texture intensity was suppressed in the final β texture, accompanied by interior α precipitation.
Cryogenic Deformation Behavior and Microstructural Characteristics of 2195 Alloy
Authors: Zhang Jin , Tan Wenfu , Wang Cheng , Zhu Chunnan , Yi Youping
Published: September 2021

Cryogenic deformation can improve the strength and plasticity of Al–Li alloy, although the underlying mechanism is still not yet well understood. The effects of cryogenic temperature on the tensile properties and microstructure of an Al–Cu–Li alloy were investigated by means of tensile property test, roughness measurement, scanning electron microscope (SEM), optical microscope (OM), electron backscatter diffraction (EBSD), and transmission electron microscope (TEM). The results indicated that the strength and elongation of the as-annealed (O-state) and solution-treated (W-state) alloys increased with the decrease in deformation temperature, where the increasing trend of elongation of the W-state alloy was more significant than that of the O-state alloy. In addition, a temperature range was observed at approximately 178 K that caused the strength of the W-state alloy to slightly decrease. The decrease in temperature inhibited the dynamic recovery of the Al–Cu–Li alloy, which increased the dislocation density and the degree of work hardening, thus improving the strength of the alloy. At cryogenic temperatures, the internal grain structure was more involved in the deformation and the overall deformation was more uniform, which caused the alloy to have higher plasticity. This study provides a theoretical basis for the cryogenic forming of Al–Li alloy.
Coupled Substitutions in Natural MnO(OH) Polymorphs: Infrared Spectroscopic Investigation
Authors: Chukanov Nikita V. , Varlamov Dmitry A. , Pekov Igor V. , Zubkova Natalia V. , Kasatkin Anatoly V. , Britvin Sergey N.
Published: September 2021

Solid solutions involving natural Mn3+O(OH) polymorphs, groutite, manganite, and feitknechtite are characterized and discussed based on original and literature data on the chemical composition, powder and single-crystal X-ray diffraction, and middle-range IR absorption spectra of these minerals. It is shown that manganite forms two kinds of solid-solution series, in which intermediate members have the general formulae (i) (Mn4+, Mn3+)O(OH,O), with pyrolusite as the Mn4+O2 end-member, and (ii) (Mn3+, M2+)O(OH, H2O), where M = Mn or Zn. In Zn-substituted manganite from Kapova Cave, South Urals, Russia, the Zn2+:Mn3+ ratio reaches 1:1 (the substitution of Mn3+ with Zn2+ is accompanied by the coupled substitution of OH− with H2O). Groutite forms solid-solution series with ramsdellite Mn4+O2. In addition, the incorporation of OH− anions in the 1 × 2 tunnels of ramsdellite is possible. Feitknechtite is considered to be isostructural with (or structurally related to) the compounds (M2+, Mn3+)(OH, O)2 (M = Mn, Zn) with a pyrochroite-related layered structure.
Mineralogical Study of Levels with Magnesian Clay Minerals in the Santos Basin, Aptian Pre-Salt Brazil
Authors: da Silva Maurício Dias , Gomes Márcia Elisa Boscato , Mexias André Sampaio , Pozo Manuel , Drago Susan Martins , Célia Raquel Severo , Silva Luis Adriano Carvalho , Netto Paulo , Gomes Lucas Bonan , Porcher Carla Cristine , Dani Norberto , Driemeyer Deborah , Ramnani Camila Wense Dias , Santos Julice Ferreira
Published: September 2021

The object of this study is magnesian clay minerals present in carbonate rocks of the post-rift phase of the pre-salt in the Santos Basin. These rocks developed in an Aptian-age alkaline lacustrine environment. This study summarizes the formation of clay minerals associated with different lithotypes in a range of 19 m and a depth of more than 5100 m. They were characterized from petrographic analysis by optical microscopy, X-ray diffraction (total sample and clay fraction), and modeling by Newmod®; and examined and analyzed by scanning electron microscopy. An approach based on identifying lithotypes and characterization of microsites allowed us to understand the occurrence of different clay minerals. Kerolite was the most abundant mineral in the sampled range. It occurs in lamellar aggregates under greater preservation of the original rock lamination and in association with spherulites and shrubs. The Stv/Ker mixed layers occurs in the same association, and formed finer unlaminated aggregates associated with the more intense dolomitization and silicification processes. Saponite occurs associated with detrital minerals forming clayey levels intercalated with microcrystalline carbonates. Fluids with a high Mg/Si and pH < 9 favor the precipitation of kerolite. The increase in pH during diagenesis may be responsible for the formation of Stv/Ker mixed layers.
Pre-Pegmatite Stage in Peralkaline Magmatic Process: Insights from Poikilitic Syenites from the Lovozero Massif, Kola Peninsula, Russia
Authors: Mikhailova Julia A. , Pakhomovsky Yakov A. , Goychuk Olga F. , Kalashnikov Andrey O. , Bazai Ayya V. , Yakovenchuk Victor N.
Published: September 2021

The Lovozero peralkaline massif (Kola Peninsula, Russia) is widely known for its unique mineral diversity, and most of the rare metal minerals are found in pegmatites, which are spatially associated with poikilitic rocks (approximately 5% of the massif volume). In order to determine the reasons for this relationship, we have investigated petrography and the chemical composition of poikilitic rocks as well as the chemical composition of the rock-forming and accessory minerals in these rocks. The differentiation of magmatic melt during the formation of the rocks of the Lovozero massif followed the path: lujavrite → foyaite → urtite (magmatic stage) → pegmatite (hydrothermal stage). Yet, for peralkaline systems, the transition between magmatic melt and hydrothermal solution is gradual. In the case of the initially high content of volatiles in the melt, the differentiation path was probably as follows: lujavrite → foyaite (magmatic stage) → urtitization of foyaite → pegmatite (hydrothermal stage). Poikilitic rocks were formed at the stage of urtitization, and we called them pre-pegmatites. Indeed, the poikilitic rocks have a metasomatic texture and, in terms of chemical composition, correspond to magmatic urtite. The reason for the abundance of rare metal minerals in pegmatites associated with poikilitic rocks is that almost only one nepheline is deposited during urtitization, whereas during the magmatic crystallization of urtite, rare elements form accessory minerals in the rock and are less concentrated in the residual solution.
Improvement of the Uniformity and Electrical Properties of Polyaniline Nanocomposite Film by Addition of Auxiliary Gases during Atmospheric Pressure Plasma Polymerization
Authors: Kim Jae-Young , Jang Hyo-Jun , Jung Eunyoung , Bae Gyutae , Lee Soonwon , Park Choon-Sang , Shin Bhumjae , Tae Heung-Sik
Published: September 2021

The morphological and chemical properties of polyaniline (PANI) nanocomposite films after adding small amounts of auxiliary gases such as argon, nitrogen, and oxygen during atmospheric pressure (AP) plasma polymerization are investigated in detail. A separate gas-supply line for applying an auxiliary gas is added to the AP plasma polymerization system to avoid plasma instability due to the addition of auxiliary gas during polymerization. A small amount of neutral gas species in the plasma medium can reduce the reactivity of monomers hyperactivated by high plasma energy and prevent excessive crosslinking, thereby obtaining a uniform and regular PANI nanocomposite film. The addition of small amounts of argon or nitrogen during polymerization significantly improves the uniformity and regularity of PANI nanocomposite films, whereas the addition of oxygen weakens them. In particular, the PANI film synthesized by adding a small amount of nitrogen has the best initial electrical resistance and resistance changing behavior with time after the ex situ iodine (I2)-doping process compared with other auxiliary gases. In addition, it is experimentally demonstrated that the electrical conductivity of the ex situ I2-doped PANI film can be preserved for a long time by isolating it from the atmosphere.
Colored Surfaces Made of Synthetic Eumelanin
Authors: Marcelo Gema , López-González María del Mar , Vega Milena , Pecharromán Carlos
Published: September 2021

The polymerization of 3,4-dihydroxy-L-phenylalanine leads to a carboxylic acid-rich synthetic melanin-like material (poly-L-DOPA). Synthetic melanin most resembles natural eumelanin in chemical structure. However, its deposition on surfaces leading to colored surfaces by interference is not as easy to accomplish as in the case of the preparation of colored surfaces by dopamine hydrochloride polymerization. This study deals with the preparation of new colored surfaces made from poly-L-DOPA displaying vivid colors by interference. These surfaces were obtained by depositing thin films of poly-L-DOPA on a reflective silicon nitride substrate. A high ionic strength in the polymerization medium was essential to accomplish the coating. The effect of ionic strength on the resulting surfaces was studied via reflectance, Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM). The refractive index was determined by ellipsometry, and was nearly constant to 1.8 when λ > 650 nm. In the visible spectral region, the imaginary part of the refractive index becomes relevant. The refractive index in the visible wavelength range (400–600 nm) was in the range 1.7–1.80.
Pd-C Catalytic Thin Films Prepared by Magnetron Sputtering for the Decomposition of Formic Acid
Authors: Arzac Gisela Mariana , Fernández Asunción , Godinho Vanda , Hufschmidt Dirk , Jiménez de Haro Maria Carmen , Medrán Beatriz , Montes Olga
Published: September 2021

Formic acid is an advantageous liquid organic hydrogen carrier. It is relatively nontoxic and can be synthesized by the reaction of CO2 with sustainable hydrogen or by biomass decomposition. As an alternative to more widely studied powdery catalysts, supported Pd-C catalytic thin films with controlled nanostructure and compositions were newly prepared in this work by magnetron sputtering on structured supports and tested for the formic acid decomposition reaction. A two-magnetron configuration (carbon and tailored Pd-C targets) was used to achieve a reduction in Pd consumption and high catalyst surface roughness and dispersion by increasing the carbon content. Activity and durability tests were carried out for the gas phase formic acid decomposition reaction on SiC foam monoliths coated with the Pd-C films and the effects of column width, surface roughness and thermal pre-reduction time were investigated. Activity of 5.04 molH2·gPd−1·h−1 and 92% selectivity to the dehydrogenation reaction were achieved at 300 °C for the catalyst with a lower column width and higher carbon content and surface roughness. It was also found that deactivation occurs when Pd is sintered due to the elimination of carbon and/or the segregation and agglomeration of Pd upon cycling. Magnetron sputtering deposition appears as a promising and scalable route for the one-step preparation of Pd-C catalytic films by overcoming the different deposition characteristics of Pd and C with an appropriate experimental design.
Two-Dimensional MFI Zeolite Nanosheets Exfoliated by Surfactant Assisted Solution Process
Authors: Rehman Aafaq ur , Arepalli Devipriyanka , Alam Syed Fakhar , Kim Min-Zy , Choi Jungkyu , Cho Churl Hee
Published: September 2021

Two-dimensional (2D) zeolite nanosheets are important for the synthesis of high flux zeolite membranes due to their lateral size in a preferred orientation. A way to obtain 2D zeolite nanosheets is to exfoliate interlocked structures generated during the hydrothermal synthesis. The mechanical and polymer assisted exfoliation process leads to mechanical damage in nanosheets and short lateral size. In the present study, polyvinylpyrrolidone (PVP) was introduced as an exfoliation agent and dispersant, so that multilamellar interlocked silicalite-1 zeolite nanosheets successfully exfoliated into a large lateral size (individual nanosheets 500~1200 nm). The good exfoliation behavior was due to the strong penetration of PVP into multilamellar nanosheets. Sonication assisted by mild milling helps PVP molecules to penetrate through the lamellar structure, contributing to the expansion of the distance between adjacent layers and thus decreasing the interactions between each layer. In addition, the stability of exfoliated nanosheets was evaluated with a series of organic solvents. The exfoliated nanosheets were well dispersed in n-butanol and stable for 30 days. Therefore, the PVP-assisted solution-based exfoliation process provides high aspect ratio MFI zeolite nanosheets in organic solvents for a long period.
Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery
Authors: Wang Zhao , Li Xinhua , Zhang Xiaojuan , Sheng Ruilong , Lin Qing , Song Wenli , Hao Lingyun
Published: September 2021

Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.
Mobility- and Energy-Aware Cooperative Edge Offloading for Dependent Computation Tasks
Authors: Mehrabi Mahshid , Shen Shiwei , Hai Yilun , Latzko Vincent , Koudouridis George , Gelabert Xavier , Reisslein Martin , Fitzek Frank
Published: September 2021

Cooperative edge offloading to nearby end devices via Device-to-Device (D2D) links in edge networks with sliced computing resources has mainly been studied for end devices (helper nodes) that are stationary (or follow predetermined mobility paths) and for independent computation tasks. However, end devices are often mobile, and a given application request commonly requires a set of dependent computation tasks. We formulate a novel model for the cooperative edge offloading of dependent computation tasks to mobile helper nodes. We model the task dependencies with a general task dependency graph. Our model employs the state-of-the-art deep-learning-based PECNet mobility model and offloads a task only when the sojourn time in the coverage area of a helper node or Multi-access Edge Computing (MEC) server is sufficiently long. We formulate the minimization problem for the consumed battery energy for task execution, task data transmission, and waiting for offloaded task results on end devices. We convert the resulting non-convex mixed integer nonlinear programming problem into an equivalent quadratically constrained quadratic programming (QCQP) problem, which we solve via a novel Energy-Efficient Task Offloading (EETO) algorithm. The numerical evaluations indicate that the EETO approach consistently reduces the battery energy consumption across a wide range of task complexities and task completion deadlines and can thus extend the battery lifetimes of mobile devices operating with sliced edge computing resources.
Selective Serotonin Reuptake Inhibitors and Clozapine: Clinically Relevant Interactions and Considerations
Authors: Edinoff Amber N. , Fort Juliana M. , Woo Joshua J. , Causey Christopher D. , Burroughs Caroline R. , Cornett Elyse M. , Kaye Adam M. , Kaye Alan D.
Published: September 2021

The monoamine hypothesis of depression attributes the symptoms of major depressive disorders to imbalances of serotonin, noradrenaline, and dopamine in the limbic areas of the brain. The preferential targeting of serotonin receptor (SERT) by selective serotonin reuptake inhibitors (SSRIs) has offered an opportunity to reduce the range of these side effects and improve patient adherence to pharmacotherapy. Clozapine remains an effective drug against treatment-resistant schizophrenia, defined as failing treatment with at least two different antipsychotic medications. Patients with schizophrenia who display a constellation of negative symptoms respond poorly to antipsychotic monotherapy. Negative symptoms include the diminution of motivation, interest, or expression. Conversely to the depressive symptomology of interest presently, supplementation of antipsychotics with SSRIs in schizophrenic patients with negative symptoms lead to synergistic improvements in the function of these patients. Fluvoxamine is one of the most potent inhibitors of CYP1A2 and can lead to an increase in clozapine levels. Similar increases in serum clozapine were detected in two patients taking sertraline. However, studies have been contradictory as well, showing no such increases, which are worrying. Clinicians should be aware that clozapine levels should be monitored with any coadministration with SSRIs.
Metabolic Control of Patients with Phenylketonuria in a Portuguese Metabolic Centre Comparing Three Different Recommendations
Authors: Kanufre Viviane , Almeida Manuela Ferreira , Barbosa Catarina Sousa , Carmona Carla , Bandeira Anabela , Martins Esmeralda , Rocha Sara , Guimas Arlindo , Ribeiro Rosa , MacDonald Anita , Pinto Alex , Rocha Júlio César
Published: September 2021

Blood phenylalanine (Phe) is used as the primary marker to evaluate metabolic control. Our study aimed to describe the metabolic control of patients with phenylketonuria (PKU) comparing three different treatment recommendations (European guidelines/US guidelines/Portuguese consensus). This was a retrospective, observational, single centre study in patients with PKU collecting data on blood Phe levels from 2017. Nutritional intake data and sapropterin (BH4) prescription were collected at the last appointment of 2017. The final sample studied included 87 patients (48% females) [13 hyperphenylalaninemia; 47 mild PKU; 27 classical PKU] with a median age of 18 y (range: 1–36 y). The median number of blood Phe measurements for patients was 21 (range: 6–89). In patients aged < 12 y, the median blood Phe level was 300 μmol/L (range 168–480) and 474 μmol/L (range 156–1194) for patients ≥ 12 y. Overall, a median of 83% of blood Phe levels were within the European PKU guidelines target range. In patients aged ≥ 12 years, there was a higher median % of blood Phe levels within the European PKU guidelines target range (≥12 y: 84% vs. <12 y: 56%). In children < 12 y with classical PKU (n = 2), only 34% of blood Phe levels were within target range for all 3 guidelines and 49% with mild PKU (n = 11). Girls had better control than boys (89% vs. 66% median Phe levels within European Guidelines). Although it is clear that 50% or more patients were unable to achieve acceptable metabolic control on current treatment options, a globally agreed upper Phe target associated with optimal outcomes for age groups is necessary. More studies need to examine how clinics with dissimilar resources, different therapeutic Phe targets and frequency of monitoring relate to metabolic control.
Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model
Authors: Kang Ji-Yun , Kim Do-Young , Lee Jin-Seok , Hwang Seung-Ju , Kim Geon-Ho , Hyun Sun-Hee , Son Chang-Gue
Published: September 2021

Central fatigue, which is neuromuscular dysfunction associated with neurochemical alterations, is an important clinical issue related to pathologic fatigue. This study aimed to investigate the anti-central fatigue effect of Korean red ginseng (KRG) and its underlying mechanism. Male BALB/c mice (8 weeks old) were subjected to periodic sleep deprivation (SD) for 6 cycles (forced wakefulness for 2 days + 1 normal day per cycle). Simultaneously, the mice were administered KRG (0, 100, 200, or 400 mg/kg) or ascorbic acid (100 mg/kg). After all cycles, the rotarod and grip strength tests were performed, and then the changes regarding stress- and neurotransmitter-related parameters in serum and brain tissue were evaluated. Six cycles of SD notably deteriorated exercise performance in both the rotarod and grip strength tests, while KRG administration significantly ameliorated these alterations. KRG also significantly attenuated the SD-induced depletion of serum corticosterone. The levels of main neurotransmitters related to the sleep/wake cycle were markedly altered (serotonin was overproduced while dopamine levels were decreased) by SD, and KRG significantly attenuated these alterations through relevant molecules including brain-derived neurotropic factor and serotonin transporter. This study demonstrated the anti-fatigue effects of KRG in an SD mouse model, indicating the clinical relevance of KRG.
Effect of Oxygen Partial Pressure on Crystal Structure, Oxygen Vacancy, and Surface Morphology of Epitaxial SrTiO3 Thin Films Grown by Ion Beam Sputter Deposition
Authors: Panomsuwan Gasidit , Saito Nagahiro
Published: September 2021

Epitaxial SrTiO3 (STO) thin films were grown on (001)-oriented LaAlO3 (LAO) substrates at 800 °C by an ion beam sputter deposition (IBSD). Oxygen partial pressure (PO2) was varied at 1.5 × 10−5, 1.5 × 10−4, and 1.5 × 10−3 Torr during the growth. The effects of PO2 on crystal structure, oxygen vacancy, and surface morphology of the STO films were investigated and are discussed to understand their correlation. It was found that PO2 played a significant role in influencing the crystal structure, oxygen vacancy, and surface morphology of the STO films. All STO films grew on the LAO substrates under a compressive strain along an in-plane direction (a- and b-axes) and a tensile strain along the growth direction (c-axis). The crystalline quality of STO films was slightly improved at higher PO2. Oxygen vacancy was favorably created in the STO lattice grown at low PO2 due to a lack of oxygen during growth and became suppressed at high PO2. The existence of oxygen vacancy could result in a lattice expansion in both out-of-plane and in-plane directions due to the presence of Ti3+ instead of Ti4+ ions. The surface roughness of the STO films gradually decreased and was nearly close to that of the bare LAO substrate at high PO2, indicating a two-dimensional (2D) growth mode. The results presented in this work provide a correlation among crystal structure, oxygen vacancy, and surface morphology of the epitaxial STO films grown by IBSD, which form a useful guideline for further study.
Formulation Development of Sublingual Cyclobenzaprine Tablets Empowered by Standardized and Physiologically Relevant Ex Vivo Permeation Studies
Authors: Majid Haidara , Puzik Andreas , Maier Tanja , Merk Raphaela , Bartel Anke , Mueller Hans-Christian , Burckhardt Bjoern
Published: September 2021

Suitable ex vivo models are required as predictive tools of oromucosal permeability between in vitro characterizations and in vivo studies in order to support the development of novel intraoral formulations. To counter a lack of clinical relevance and observed method heterogenicity, a standardized, controlled and physiologically relevant ex vivo permeation model was established. This model combined the Kerski diffusion cell, process automation, novel assays for tissue integrity and viability, and sensitive LC-MS/MS analysis. The study aimed to assess the effectiveness of the permeation model in the sublingual formulation development of cyclobenzaprine, a promising agent for the treatment of psychological disorders. A 4.68-fold enhancement was achieved through permeation model-led focused formulation development. Here, findings from the preformulation with regard to pH and microenvironment-modulating excipients proved supportive. Moreover, monitoring of drug metabolism during transmucosal permeation was incorporated into the model. In addition, it was feasible to assess the impact of dosage form alterations under stress conditions, with the detection of a 33.85% lower permeation due to salt disproportionation. Integrating the coherent processes of disintegration, dissolution, permeation, and metabolization within a physiological study design, the model enabled successful formulation development for cyclobenzaprine sublingual tablets and targeted development of patient-oriented drugs for the oral cavity.