bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Daily Emotional Labor on Health and Well-Being
Authors: Riforgiate Sarah E. , Howes Satoris S. , Simmons Mathias J.
Published: September 2021

Emotional labor research largely focuses on client-facing occupations. However, employees across occupations engage in emotional labor when they perceive that specific types of emotional communication are required to align with organizational expectations. The current two-week daily survey study of 42 employees was conducted at a small website development company to examine relationships between employees’ emotional labor, physical health, and psychological well-being. Results indicated that daily emotional labor surface acting was significantly negatively related to daily psychological well-being and daily physical health. However, daily emotional labor deep acting was not significantly related to daily psychological well-being or daily physical health. After aggregating emotional labor across days, results revealed a significant positive relationship between emotional labor and burnout. This study enhances organizational awareness of the relationship between emotional communication expectations and employees’ psychological and physical health. Research-driven practices are detailed to ameliorate the negative side effects of emotional labor communication demands.
Elliptical torus cutter tool path generation based on minimum distance computation
Authors: Zhao Mingbo , Cai Yonglin , Wang Haitong
Published: September 2021

In mould manufacture the elliptical torus cutters are used for their high cutting velocity, but the special geometry also brings issues in tool path generating and machining quality controlling. In this paper a guide curve tool path generating method for elliptical torus cutters is presented with the cutter location points computed by a minimum distance algorithm and the path spacing determined by an adaptive method. In the minimum distance algorithm, the calculation is resolved into an iterative process from point to freeform surface and an algebraic calculation process from point to elliptical torus surface considering the geometry of the cutter, which reduces the iterative process and improves the computing speed. In the adaptive path spacing method, the contacting geometry between the elliptical cutter and the workpiece surface is analysed and the relations among the scallop height, the tool tilt angle and the path spacing are deduced, based on which the guide curves are adjusted in advance to control the scallop height. Calculating examples and experiments are carried out, showing that the consuming time of cutter location (CL) points computation algorithm is reduced by 30% comparing to earlier method, and the adaptive path spacing method performs better than constant method in both scallop height controlling and tool path shortening. The results indicate that the presented tool path generating method can help to reduce both the machining and machine waiting time as well as ensuring the machining quality.
Repackaging Primary Healthcare in Odisha: Can ‘Task Shifting’ to AYUSH Doctors Address Human Resources Deficit?
Authors: Kadam Shridhar , Panda Bhuputra , Nallala Srinivas , Pati Sanghamitra , Hussain Mohammed Akhtar , Salunke Subhash , Zodpey Sanjay
Published: September 2021

Provision of primary healthcare in India received thrust of National Health Policy 2017. Vacancy, chronic absenteeism and non-availability of allopathic doctors is a chronic problem of the public health system. Engagement of alternative human resources could get the ailing health system rid of this shortage. AYUSH doctors in Odisha are involved in clinical and public health activities since 1970s. This study aims to examine perspectives of key stakeholders on ‘task shifting’ as a possible policy alternative.

We reviewed the policies and guidelines of government of Odisha on human resources deployment, recruitment, retention and terms of reference of their engagement in the public health sector. Further, 76 AYUSH doctors and 30 key informants were interviewed. Ethical clearance was obtained beforehand.

Most AYUSH doctors were involved in monitoring and supervising community-based public health programmes and village-level health service providers, respectively. Their involvement in the implementation of national health programmes was found to range from 8% to 62%. A sizeable proportion of AYUSH doctors had not been trained on management of national vector borne disease control, Tuberculosis control, immunisation (RI) and disease surveillance. More than 70% of respondents showed interest in implementing and managing public health programmes. Almost all key informants recommended for improved involvement of AYUSH doctors in public health activities. Inadequate logistics support, insufficient training on public health and unequal administrative authorities was perceived to be systemic bottlenecks.

Job enrichment, management capacity development, and pre-deployment orientation of AYUSH doctors may precede the opportunity of ‘task-shifting’ of public health functions.
Relational–Cultural Theory: A Supportive Framework for Transracial Adoptive Families
Authors: Branco Susan F.
Published: September 2021

Transracially adopted children and adolescents are subject to increased risks to their mental health and identity development as a result of racism and microaggressions. The risks are exacerbated by limited racial–ethnic socialization from their mostly White adoptive parents. This article reviews the history of transracial adoption in the United States through the lens of colonization, describes research related to racism and its impact on transracially adopted children, and recommends relational–cultural theory as a supportive framework for school, mental health, and family counselors.
Association Between LIN28A Gene Polymorphisms and Glioma Susceptibility in Chinese Children
Authors: Guo Huiqin , Liao Yuxiang , Lin Ao , Lin Huiran , Huang Xiaokai , Ruan Jichen , Yuan Li , Zhuo Zhenjian
Published: September 2021

Gliomas are the most prevalent brain tumors among children and adolescents. The occurrence and development of various malignant tumors is closely related with LIN28A gene, but its relationship with glioma susceptibility has not been widely discovered. In this case-control study, we conducted four single nucleotide polymorphisms (SNPs) (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) of LIN28A gene to investigate whether they increase the risk of glioma. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate their relationship. There was no significant correlation between four SNPs and glioma risk in single polymorphism and conjoint analysis. However, in stratification analysis, we found that rs3811463 TC/CC may add to the risk of glioma with clinical stage III (adjusted OR = 3.16, 95% CI = 1.15-8.70, P = .026) or stage III+IV patients (adjusted OR = 2.05, 95% CI = 1.02-4.13, P = .044). Our research suggested that four SNPs of LIN28A gene have a weak relationship with the risk of glioma in Chinese children. LIN28A rs3811463 TC/CC may increase the possibility of glioma in clinical stage III or stage III+IV patients which need larger samples and further confirmation.
Frequency weighting to evaluate the feeling of pressure and/or vibration caused by low-frequency noise: Re-analysis of an existing study
Authors: Tagusari Junta , Sato Sho , Matsui Toshihito
Published: September 2021

Low-frequency noise may create specific perceptions, which might cause various health effects. The present study aimed to identify exposure–response relationships between low-frequency noise and perceptions by re-analysing an experimental study. We investigated the predominant perceptions of ‘feeling bothered’ and ‘feeling of pressure and/or vibration’ using multivariate logistic regression analysis. A significant interaction between 1/3 octave-band sound pressure level and frequency was indicated for ‘feeling bothered’ but not ‘feeling of pressure and/or vibration’, suggesting that the ‘feeling of pressure and/or vibration’ does not originate in cochlear. A mathematical model indicating resonance at approximately 50 Hz fitted the results well. A frequency weighting derived from the mathematical model could be applied to broad-band low-frequency noise to evaluate the perception and health effects. However, further investigations on the weighting for the perception are necessary because the results were obtained only from the existing study.
An appropriate biomechanical model of seated human subjects exposed to whole-body vibration
Authors: Desai Raj , Guha Anirban , Seshu Pasumarthy
Published: September 2021

Long duration automobile-induced vibration is the cause of many ailments to humans. Predicting and mitigating these vibrations through seat requires a good model of seated human body. A good model is the one that strikes the right balance between modelling difficulty and simulation results accuracy. Increasing the number of body parts which have been separately modelled and increasing the number of ways these parts are connected to each other increase the number of degrees of freedom of the entire model. A number of such models have been reported in the literature. These range from simple lumped parameter models with limited accuracy to advanced models with high computational cost. However, a systematic comparison of these models has not been reported till date. This work creates eight such models ranging from 8 to 26 degrees of freedom and tries to identify the model which strikes the right balance between modelling complexity and results accuracy. A comparison of the models’ prediction with experimental data published in the literature allows the identification of a 12 degree of freedom backrest supported model as optimum for modelling complexity and prediction accuracy.
Perceptions of Cervical Cancer Screening in Rural Guatemala
Authors: Bassette Emma , Mabachi Natabhona , Kennedy Michael , Mendez-Puac Francisco
Published: September 2021

Cervical cancer (CC) is the second most common cause of cancer-related mortality in the developing world. Globally, the incidence of CC is 13.1 per 100,000, with the highest incidence of CC seen in sub-Saharan Africa, Melanesia, Latin America and the Caribbean, Southcentral Asia, and Southeast Asia. Little data exist regarding perceptions of screening in Guatemala and how this may affect the likelihood that women seek care. This study aimed to assess the attitudes, perceptions, and beliefs of CC screening in women of Rural Guatemala. A cross-sectional mixed method analysis was administered using a survey given to 169 women in San Pedro La Laguna in Sololá, Guatemala. Results showed that none of the indigenous-language-speaking patients and only half of the bilingual patients had knowledge of human papillomavirus; 97% of women indicated that they believed regular Pap smears are important; only 46.4% of women screened had received a Pap smear at some point in their lives, which is slightly above the national average (39.3%). This is due to barriers to access, cost of treatment, and knowledge of CC. Results of this study display a positive perception of CC screening by indigenous women, indicating that efforts should be made to move toward the implementation of low-cost CC screening methods.
Health Literacy in Primary Care: Reflections and Suggestions for Physicians, Researchers, and Administrators
Authors: Sprogell Anne , Casola Allison R. , Cunningham Amy
Published: September 2021

As the healthcare system evolves, it is becoming more complicated for physicians and patients. Patients might have had one doctor in the past, but now are likely to regularly see several specialists along with their primary care physician. Patients can access their health records online, which increases transparency and accountability, but adds more information they have to interpret. This is the concept of health literacy—the ability to obtain, process, and act upon information regarding one’s health. This article will characterize health literacy in primary care and provide three areas that primary care physicians and researchers can direct their focus in order to increase health literacy among patients: community engagement, trainee education, and examination of personal bias.
Whole-Foods, Plant-Based Diet Perceptions of Medical Trainees Compared to Their Patients: A Cross-Sectional Pilot Study
Authors: Morton Kara F. , Pantalos Diana C. , Ziegler Craig , Patel Pradip D.
Published: September 2021

Purpose: To evaluate medical trainees’ and patients’ perceptions of the utility of a whole-foods, plant-based (WFPB) diet for chronic disease management. Methods: A cross-sectional study using two original survey tools was implemented. Quantitative and qualitative data were collected from trainees and patients to evaluate perceived motivations and barriers to WFPB diet implementation. Results: Two hundred trainees and 52 patients responded to the surveys. Nearly half (48%) of patients were willing to try a WFPB diet, expressing a desire for additional information and help with its practical application. Over half (53%) of trainees were willing to recommend a WFPB diet to patients but expressed concern about its acceptability and feasibility. Patients perceived significantly more barriers related to personal enjoyment of animal products while trainees perceived more socioeconomic barriers. Conclusion: Poor diet has been identified as the United States’ leading risk factor for mortality from chronic diseases. Plant-predominant diets, such as a WFPB diet, are associated with improved health outcomes and may be an acceptable solution for many patients. WFPB dietary modification could be pursued with a motivational interviewing approach that targets patients’ individual goals. Medical providers should address their own assumptions regarding the dietary changes their patients are willing to make.
Phonological precision for word recognition in skilled readers
Authors: Elsherif Mahmoud M , Wheeldon Linda Ruth , Frisson Steven
Published: September 2021

According to the lexical quality hypothesis, differences in the orthographic, semantic, and phonological representations of words will affect individual reading performance. While several studies have focused on orthographic precision and semantic coherence, few have considered phonological precision. The present study used a suite of individual difference measures to assess which components of lexical quality contributed to competition resolution in a masked priming experiment. The experiment measured form priming for word and pseudoword targets with dense and sparse neighbourhoods in 84 university students. Individual difference measures of language and cognitive skills were also collected and a principal component analysis was used to group these data into components. The data showed that phonological precision and NHD interacted with form priming. In participants with high phonological precision, the direction of priming for word targets with sparse neighbourhoods was facilitatory, while the direction for those with dense neighbourhoods was inhibitory. In contrast, people with low phonological precision showed the opposite pattern, but the interaction was non-significant. These results suggest that the component of phonological precision is linked to lexical competition for word recognition and that access to the mental lexicon during reading is affected by differing levels of phonological processing.
Risk-informed control systems for improved operational performance and decision-making
Authors: Thieme Christoph A , Rokseth Børge , Utne Ingrid B
Published: September 2021

Autonomous systems, including airborne, land-based, marine, and underwater vehicles, are increasingly present in the world. One important aspect of autonomy is the capability to process information and to make independent decisions for achieving a mission goal. Information on the level of risk related to the operation may improve the decision-making process of autonomous systems. This article describes the integration of risk analysis methods with the control system of autonomous and highly automated systems that are evaluated during operation. Four main areas of implementation are identified; (i) risk models used to directly make decisions, (ii) use of the output of risk models as input to decision-making and optimization algorithms, (iii) the output of risk models may be used as a constraint in or modifying constraints of algorithms, and (iv) the output of risk models may be used to inform representations or maps of the environment to be used in path planning. A case study on a dynamic positioning controller of an offshore supply vessel exemplifies the concepts described in this article. In addition, it demonstrates how risk model output may be used within a hybrid controller.
Police capacity and autonomy issues in sectarian crimes and enforcement of anti-terror laws in Punjab
Authors: Umar Muhammad
Published: September 2021

Contemporary research mainly relates police ineffectiveness in sectarian crimes prevention-investigation and enforcement of anti-terror laws to disorganized police infrastructure, a shortage of manpower, a lack of professionalism and limited access to modern equipment. This article, by applying capacity (i.e. manpower, resources, professional and technical training, etc.) and autonomy (effective and neutral exercise of powers within mandates delegated to them) concepts, aims to examine police effectiveness in the enforcement of anti-sectarian laws in the context of interference in their functions by the political executive and the State’s Army. It addresses the question: How do police capacity and autonomy issues affect police effectiveness in prevention-investigation of sectarian crimes and enforcement of anti-terror laws? This article applies a mixed method research approach by using data from books, journal articles, newspapers, TV talk shows, online sources and interviews. It relates the police’s effectiveness in prevention-investigation of sectarian crimes and enforcement of anti-terror laws to their capacity and autonomy issues in the Punjab Province of Pakistan. It argues that the police due to capacity and autonomy issues cannot exercise delegated powers impartially, which affects their effectiveness in prevention-investigation of sectarian crimes and enforcement of anti-terror laws.
Issues and contentions in the incursion of Islam and Christianity into Ilé-Ifè, southwestern Nigeria
Authors: Aghalino Samuel O. , Elugbaju Ayowole S.
Published: September 2021

The late ninetieth century marked the period when Ilé-Ifè, the reputed cradle of the Yoruba people, witnessed the penetration of Christianity and Islam. Specifically, from the 1890s, both religions established a few years apart through several actors and factors, operated concurrently within Ilé-Ifè. However, the accounts surrounding the periods, initiators and several issues associated with the establishment of these religions have, in the history of Ilé-Ifè, become themes of contention that should be further interrogated from a historical perspective. This study employed primary and secondary data in examining the contested arguments in the narratives surrounding the incursion of these religions in Ilé-Ifè within the context of identifying pitfalls and providing a guide for future studies related to this theme. This study discovered that the issues and contentions include the primordial projection of narratives; and the conflation of the identities of the initiators of the religions, to mention a few. The study is concluded by drawing some lessons from the early peaceful coexistence between the adherents of the two religions in Ilé-Ifè.
Health-related quality of life and fatigue in children and adults with pyruvate kinase deficiency
Authors: Al-Samkari Hanny , van Beers Eduard J. , Morton D. Holmes , Eber Stefan W. , Chonat Satheesh , Kuo Kevin H. M. , Kollmar Nina , Wang Heng , Breakey Vicky R. , Sheth Sujit , Sharma Mukta , Forbes Peter W. , Klaassen Robert J. , Grace Rachael F.
Published: September 2021

Pyruvate kinase deficiency (PKD) is the most common cause of congenital nonspherocytic hemolytic anemia. Although recognition of the disease spectrum has recently expanded, data describing its impact on health-related quality of life (HRQoL) are limited. In this prospective international cohort of 254 patients (131 adults and 123 children) with PKD, we used validated measures to assess the impact of disease on HRQoL (EuroQol 5-Dimension Questionnaire, Pediatric Quality of Life Inventory Generic Core Scale version 4.0, and Functional Assessment of Cancer Therapy-Anemia) and fatigue (Patient Reported Outcomes Measurement Information System Fatigue and Pediatric Functional Assessment of Chronic Illness Therapy-Fatigue). Significant variability in HRQoL and fatigue was reported for adults and children, although individual scores were stable over a 2-year interval. Although adults who were regularly transfused reported worse HRQoL and fatigue compared with those who were not (EuroQol-visual analog scale, 58 vs 80; P = .01), this difference was not seen in children. Regularly transfused adults reported lower physical, emotional, and functional well-being and more anemia symptoms. HRQoL and fatigue significantly differed in children by genotype, with the worst scores in those with 2 severe PKLR mutations; this difference was not seen in adults. However, iron chelation was associated with significantly worse HRQoL scores in children and adults. Pulmonary hypertension was also associated with significantly worse HRQoL. Additionally, 59% of adults and 35% of children reported that their jaundice upset them, identifying this as an important symptom for consideration. Although current treatments for PKD are limited to supportive care, new therapies are in clinical trials. Understanding the impact of PKD on HRQoL is important to assess the utility of these treatments. This trial was registered at www.clinicaltrials.gov as #NCT02053480.
The definition of pulmonary hypertension: history, practical implications and current controversies
Authors: Kovacs Gabor , Olschewski Horst
Published: September 2021

The definition of pulmonary hypertension (PH) is based on a growing body of evidence and represents the result of ongoing discussions within the PH community over the past 50 years. In 2018, the most recent World Symposium on Pulmonary Hypertension introduced significant changes in the definition of PH by lowering the mean pulmonary arterial pressure threshold to >20 mmHg and (re)introducing the pulmonary vascular resistance ≥3 WU cut-off for all forms of pre-capillary PH. These changes and their potential clinical impact have been the subject of lively discussions in the community and some important questions and controversies have been identified.

In this review we aim to present the development of the definition of PH over the past decades and discuss the main arguments that led to relevant modifications. In addition, we address the practical implications of the most recent changes and controversies that still exist.

Educational aims

To review the historical development of the definition of pulmonary hypertension.

To discuss practical implications and current controversies of the currently recommended definitions of pulmonary hypertension and pulmonary arterial hypertension.
Is BRD7 associated with spermatogenesis impairment and male infertility in humans? A case-control study in a Han Chinese population
Authors: He Tianrong , Liu Mohan , Tao Dachang , Leng Xiangyou , Wang Zhaokun , Xie Shengyu , Zhang Yangwei , Zhang Xinyue , Tan Xiaolan , Liu Yunqiang , Yang Yuan
Published: September 2021

Background

Bromodomain-containing protein 7 (BRD7), a member of the bromodomain-containing protein family, plays important roles in chromatin modification and transcriptional regulation. A recent model of Brd7-knockout mice presented azoospermia and male infertility, implying the potential role of BRD7 in spermatogenic failure in humans. This case-control study aimed to explore the association of the BRD7 gene with spermatogenic efficiency and the risk of spermatogenic defects in humans.

Results

A total of six heterozygous variants were detected in the coding and splicing regions of the BRD7 gene in patients with azoospermia. For each of four rare variants predicted to potentially damage BRD7 function, we further identified these four variants in oligozoospermia and normozoospermia as well. However, no difference in the allele and genotype frequencies of rare variants were observed between cases with spermatogenic failure and controls with normozoospermia; the sperm products of variant carriers were similar to those of noncarriers. Moreover, similar distribution of the alleles, genotypes and haplotypes of seven tag single nucleotide polymorphisms (tagSNPs) was observed between the cases with azoospermia and oligozoospermia and controls with normozoospermia; associations of tagSNP-distinguished BRD7 alleles with sperm products were not identified.

Conclusions

The lack of an association of BRD7-linked rare and common variants with spermatogenic failure implied a limited contribution of the BRD7 gene to spermatogenic efficiency and susceptibility to male infertility in humans.
Prediction of cardiovascular risk in patients with chronic obstructive pulmonary disease: a study of the National Health and Nutrition Examination Survey database
Authors: Shi Yun , Zhang Jing , Huang Yingshuo
Published: September 2021

Background

Cardiovascular disease (CVD) is a common comorbidity associated with chronic obstructive pulmonary disease (COPD), but few studies have been conducted to identify CVD risk in COPD patients. This study was to develop a predictive model of CVD in COPD patients based on the National Health and Nutrition Examination Survey (NHANES) database.

Methods

A total of 3,226 COPD patients were retrieved from NHANES 2007–2012, dividing into the training (n = 2351) and testing (n = 895) sets. The prediction models were conducted using the multivariable logistic regression and random forest analyses, respectively. Receiver operating characteristic (ROC) curves, area under the curves (AUC) and internal validation were used to assess the predictive performance of models.

Results

The logistic regression model for predicting the risk of CVD was developed regarding age, gender, body mass index (BMI), high-density lipoprotein (HDL), glycosylated hemoglobin (HbA1c), family history of heart disease, and stayed overnight in the hospital due to illness last year, which the AUC of the internal validation was 0.741. According to the random forest analysis, the important variables-associated with CVD risk were screened including smoking (NNAL and cotinine), HbA1c, HDL, age, gender, diastolic blood pressure, poverty income ratio, BMI, systolic blood pressure, and sedentary activity per day. The AUC of the internal validation was 0.984, indicating the random forest model for predicting the CVD risk in COPD cases was superior to the logistic regression model.

Conclusion

The random forest model performed better predictive effectiveness for the cardiovascular risk among COPD patients, which may be useful for clinicians to guide the clinical practice.
Network analysis of the relationship between negative life events and depressive symptoms in the left-behind children
Authors: Li Kuiliang , Guang Yu , Ren Lei , Zhan Xiaoqing , Tan Xuejiao , Luo Xi , Feng Zhengzhi
Published: September 2021

Background

There are 68.77 million left-behind children in China, who are at a great risk of depression associated with negative life events. Our study aims to investigate the most central symptoms of depression in left-behind children and the relationship between depressive symptoms and negative life events using network analysis.

Method

A cross-sectional data set (N = 7255) was used, which included children and adolescents aged 7 to 17. Network analysis was used to evaluate: 1) the most central symptoms among the items included in Child Depression Inventory (CDI) of the left-behind children; 2) bridge symptoms between depressive disorder and Adolescent Self-Rating Life Events Check List (ASLEC) of the left-behind children; 3) differences in networks of depressive disorders between left-behind and non-left-behind children, and 4) differences in the network of depression and negative life events between left-behind and non-left-behind children. The stability and centrality indices of the network were also evaluated in the study.

Results

The most central symptoms in the CDI among the left-behind children included self-hatred, crying, fatigue, and sadness. The items with the highest bridge strength centrality in the CDI-ASLEC network included academic stress, discrimination, and school performance decrement. Higher bridge strength values indicate a greater risk of contagion to other communities. The connections in the CDI-ASLEC network are denser in the left-behind children than in non-left-behind children.

Limitations

The study which was conducted based on cross-sectional data shows that network analysis can only make undirected estimation, but not causal inferences.

Conclusions

We identified the core symptoms of depression and the bridge symptoms between negative life events and depression in the left-behind children. These findings suggest that more attention should be paid to self-hatred, sadness, and fatigue in the treatment of depression in left-behind children. Intervention for academic stress and discrimination of the left-behind children may help to reduce the contagion of negative life events to depression symptoms.
Prevalence and risk factors for latent tuberculosis in polish healthcare workers: the comparison of tuberculin skin test and interferon-gamma release assay (IGRA) performance
Authors: Szturmowicz Monika , Broniarek-Samson Beata , Demkow Urszula
Published: September 2021

Background

Tuberculosis (TB) is still one of the most common infectious diseases worldwide. Health care workers (HCW) are at particular risk of the disease due to their constant exposure to TB patients or their specimens, nevertheless no specific surveillance is widely recommended in this group of professionals. Both, tuberculin skin test (TST) and interferon-gamma-release-assays (IGRAs) are widely applied to detect latent tuberculosis infection (LTBI). The aim of the present study was to evaluate the prevalence and risks of LTBI in the population of Polish HCW, to identify factors associated with LTBI, as well as to determine the rate of the discordance between the results of the two applied tests in relation to various factors in a TB endemic setting. The study participants were recruited from several health care facilities (hospitals and outpatients clinics) all over the country. Laboratory personnel included 156 persons from both TB and non-TB laboratories (118 clinical pathologists, 38 laboratory technicians), 31 medical doctors, 29 nurses (from both TB and non-TB wards and from family practices), 6 other medical employees (patients assistants). Out of examined group 88 (40%) declared constant (everyday) occupational contact with TB patients and/or contagious biologic materials, 134 (60%) reported sporadic (incidental) contact (few times a year). Administrative HCWs who were not in direct contact with patients were not included in the study group.

Material and methods

LTBI status was prospectively evaluated in 222 HCW, 204 females, 18 males, aged 40.8 ± 9 years, with tuberculin skin test (TST) and interferon gamma release assay (QuantiFERON-TB-Gold in Tube – QFT GIT).

Results

TST ≥ 10 mm was found in 58% of HCW, QFT GIT ≥ 0.35 IU/ml in 23%. Nevertheless the relative number of positive QFT GIT in HCW above 45 years of age exceeded those obtained in general population (prevalence of positive QTF test in polish adult population is around 23%). The risk of obtaining positive QFT GIT was significantly increased in the participants older than 44 years (OR = 4.95, 95%CI:2.375–10.193), in those employed > 10 years (OR = 2.726, 95%CI:1.126–6.599), and in those who reported the direct contact with tuberculous patients or infected biological materials (OR = 8.135, 95%CI:1.297–51.016). The concordance between TST and IGRA was poor (kappa 0.23), especially in younger participants, possibly due to BCG vaccination in childhood.

Conclusion

The increased risk of LTBI in Polish HCW was related to age, duration of employment and contact with infectious patients or their biological specimens. TB infection control measures in health care facilities in Poland are still insufficient. It is crucial to increase awareness about the importance of detecting and treating LTBI of HCW.
Nomogram for predicting reoperation following internal fixation of nondisplaced femoral neck fractures in elderly patients
Authors: Zhu Jian , Hu Hongzhi , Deng Xiangtian , Zhang Yiran , Cheng Xiaodong , Tan Zhanchao , Zhu Yanbin , Zhang Yingze
Published: September 2021

Objective

We aimed to evaluate risk factors and develop a nomogram for reoperation after internal fixation of nondisplaced femoral neck fractures (FNFs) in elderly patients.

Methods

We conducted a retrospective study involving a total of 255 elderly patients who underwent closed reduction and internal fixation with cannulated screw system for nondisplaced FNFs between January 2016 and January 2019. We collected data on demographics, preoperative radiological parameters, surgery, serum biochemical markers, and postoperative rehabilitation. In addition, we performed univariate and multivariate logistic regression analyses to determine independent risk factors for reoperation, and then developed a nomogram to assess the risks of reoperation. Besides, discriminative ability, calibration, and clinical usefulness of the nomogram were evaluated using the concordance index (C-index), the receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis (DCA), respectively. We employed bootstrap method to validate the performance of the developed nomogram.

Results

Our analysis showed that among the 255 patients, 28 (11.0%) underwent reoperation due to osteonecrosis of the femoral head (14 cases), mechanical failure (8 cases) or nonunion (6 cases). All of the 28 patients underwent conversion surgery to arthroplasty. The multivariate logistic regression analysis demonstrated that preoperative posterior tilt angle ≥ 20°, Pauwel’s III type, younger patients, preoperative elevated levels of alkaline phosphatase (ALP), preoperative hypoalbuminemia, and early postoperative weight-bearing were independent risk factors for reoperation. In addition, the C-index and the bootstrap value of the developed nomogram was 0.850 (95% CI = 0.803–0.913) and 0.811, respectively. Besides, the calibration curve showed good consistency between the actual diagnosed reoperation and the predicted probability, while the DCA indicated that the nomogram was clinically valuable.

Conclusions

Our analysis showed we successfully developed and validated a nomogram for personalized prediction of reoperation after internal fixation of nondisplaced FNFs in elderly patients. This model would help in individualized evaluation of the need for reoperation and inform strategies aimed at eliminating the need for the reoperation.
De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity
Authors: Moosavi Seyed H. , Eide Peter W. , Eilertsen Ina A. , Brunsell Tuva H. , Berg Kaja C. G. , Røsok Bård I. , Brudvik Kristoffer W. , Bjørnbeth Bjørn A. , Guren Marianne G. , Nesbakken Arild , Lothe Ragnhild A. , Sveen Anita
Published: September 2021

Background

Gene expression-based subtyping has the potential to form a new paradigm for stratified treatment of colorectal cancer. However, current frameworks are based on the transcriptomic profiles of primary tumors, and metastatic heterogeneity is a challenge. Here we aimed to develop a de novo metastasis-oriented framework.

Methods

In total, 829 transcriptomic profiles from patients with colorectal cancer were analyzed, including primary tumors, liver metastases, and non-malignant liver samples. High-resolution microarray gene expression profiling was performed of 283 liver metastases from 171 patients treated by hepatic resection, including multiregional and/or multi-metastatic samples from each of 47 patients. A single randomly selected liver metastasis sample from each patient was used for unsupervised subtype discovery by nonnegative matrix factorization, and a random forest prediction model was trained to classify multi-metastatic samples, as well as liver metastases from two independent series of 308 additional patients.

Results

Initial comparisons with non-malignant liver samples and primary colorectal tumors showed a highly variable degree of influence from the liver microenvironment in metastases, which contributed to inter-metastatic transcriptomic heterogeneity, but did not define subtype distinctions. The de novo liver metastasis subtype (LMS) framework recapitulated the main distinction between epithelial-like and mesenchymal-like tumors, with a strong immune and stromal component only in the latter. We also identified biologically distinct epithelial-like subtypes originating from different progenitor cell types. LMS1 metastases had several transcriptomic features of cancer aggressiveness, including secretory progenitor cell origin, oncogenic addictions, and microsatellite instability in a microsatellite stable background, as well as frequent RAS/TP53 co-mutations. The poor-prognostic association of LMS1 metastases was independent of mutation status, clinicopathological variables, and current subtyping frameworks (consensus molecular subtypes and colorectal cancer intrinsic subtypes). LMS1 was also the least heterogeneous subtype in comparisons of multiple metastases per patient, and tumor heterogeneity did not confound the prognostic value of LMS1.

Conclusions

We report the first large study of multi-metastatic gene expression profiling of colorectal cancer. The new metastasis-oriented subtyping framework showed potential for clinically relevant transcriptomic classification in the context of metastatic heterogeneity, and an LMS1 mini-classifier was constructed to facilitate prognostic stratification and further clinical testing.
Late chronotype predicts more depressive symptoms in bipolar disorder over a 5 year follow-up period
Authors: Vidafar Parisa , Yocum Anastasia K. , Han Peisong , McInnis Melvin G. , Burgess Helen J.
Published: September 2021

Background

There is increasing evidence that bipolar disorder is influenced by circadian timing, including the timing of sleep and waking activities. Previous studies in bipolar disorder have shown that people with later timed daily activities, also known as late chronotypes, are at higher risk for subsequent mood episodes over the following 12–18 months. However, these studies were limited to euthymic patients and smaller sample sizes. The aim of the current study was to further examine baseline chronotype as a potentially important predictor of mood-related outcomes in a larger sample of individuals with bipolar disorder and over the longest follow up period to date, of 5 years. Participants included 318 adults diagnosed with bipolar I and II (19–86 years) who were enrolled in the Prechter Longitudinal Study of Bipolar Disorder.

Results

Participants with a late chronotype were found to be more likely to have mild to more severe depressive symptoms (PHQ-9 ≥ 5) as captured with PHQ-9 assessments every 2 months over the 5 year follow up period. This higher risk for depressive symptoms remained even after adjusting for age, sex and mood at baseline. Additionally, late chronotypes reported fewer hypomania/mania episodes during the 5 year follow up, as derived from clinical interviews every two years.

Conclusions

These results highlight the potential clinical usefulness of a single self-report question, in identifying patients at risk for a more depressive mood course. The results also suggest that circadian phase advancing treatments, that can shift circadian timing earlier, should be explored as a means to reduce depressive symptoms in late chronotypes with bipolar disorder.
Exploring the association between occupational complexity and numeracy
Authors: Billington Mary Genevieve , Foldnes Njål
Published: September 2021

The basic cognitive skill of numeracy is a recognized form of human capital, associated with economic and social well being for individuals and for nations. In this study, we explore how occupational complexity relates to proficiency in numeracy, among adults in full-time employment. We operationalize occupational complexity by constructing three measures of task complexity: complexity with data, complexity with people and complexity with things. Data from the international OECD survey of adult skills, 2012, is employed to investigate both the distribution of these three dimensions of occupational task complexity and how these relate to numeracy in 13 countries. The analysis indicates that data occupational complexity predicts numeracy scores, when controlling for age, gender and educational level. The findings open for a hypothesis that occupational activities may enhance basic skills in adult populations. If elaborated and supported through further studies this finding has practical implications for workplace organization and contributes to theoretical understandings of the development of basic skills in adults.
Social prediction: a new research paradigm based on machine learning
Authors: Chen Yunsong , Wu Xiaogang , Hu Anning , He Guangye , Ju Guodong
Published: September 2021

Sociology is a science concerned with both the interpretive understanding of social action and the corresponding causal explanation, process, and result. A causal explanation should be the foundation of prediction. For many years, due to data and computing power constraints, quantitative research in social science has primarily focused on statistical tests to analyze correlations and causality, leaving predictions largely ignored. By sorting out the historical context of "social prediction," this article redefines this concept by introducing why and how machine learning can help prediction in a scientific way. Furthermore, this article summarizes the academic value and governance value of social prediction and suggests that it is a potential breakthrough in the contemporary social research paradigm. We believe that through machine learning, we can witness the advent of an era of a paradigm shift from correlation and causality to social prediction. This shift will provide a rare opportunity for sociology in China to become the international frontier of computational social sciences and accelerate the construction of philosophy and social science with Chinese characteristics.
The biology of bone morphogenetic protein signaling pathway in cerebrovascular system
Authors: Tang Haishuang , Zhang Xiaoxi , Xue Gaici , Xu Fengfeng , Wang Qingsong , Yang Pengfei , Hong Bo , Xu Yi , Huang Qinghai , Liu Jianmin , Zuo Qiao
Published: September 2021

Bone morphogenetic protein belongs to transcription growth factor superfamily β; bone morphogenetic protein signal pathway regulates cell proliferation, differentiation, and apoptosis among different tissues. Cerebrovascular system supplies sufficient oxygen and blood into brain to maintain its normal function. The disorder of cerebrovascular system will result into serious cerebrovascular diseases, which is gradually becoming a major threat to human health in modern society. In recent decades, many studies have revealed the underlying biology and mechanism of bone morphogenetic protein signal pathway played in cerebrovascular system. This review will discuss the relationship between the two aspects, aiming to provide new perspective for non-invasive treatment and basic research of cerebrovascular diseases.
From mechanism-based to data-driven approaches in materials science
Authors: Hiemer Stefan , Zapperi Stefano
Published: September 2021

A time-honored approach in theoretical materials science revolves around the search for basic mechanisms that should incorporate key feature of the phenomenon under investigation. Recent years have witnessed an explosion across areas of science of a data-driven approach fueled by recent advances in machine learning. Here we provide a brief perspective on the strengths and weaknesses of mechanism based and data-driven approaches in the context of the mechanics of materials. We discuss recent literature on dislocation dynamics, atomistic plasticity in glasses focusing on the empirical discovery of governing equations through artificial intelligence. We conclude highlighting the main open issues and suggesting possible improvements and future trajectories in the fields.
Current advances in pathogen-plant interaction between Verticillium dahliae and cotton provide new insight in the disease management
Authors: PALANGA Koffi Kibalou , LIU Ruixian , GE Qun , GONG Juwu , LI Junwen , LU Quanwei , LI Pengtao , YUAN Youlu , GONG Wankui
Published: September 2021

Verticillium wilt is the second serious vascular wilt caused by the phytopathogenic fungus Verticillium dahliae Kleb. It has distributed worldwide, causing serious yield losses and fiber quality reduction in cotton production. The pathogen has developed different mechanisms like the production of cell wall degrading enzymes, activation of virulence genes and protein effectors to succeed in its infection. Cotton plant has also evolved multiple mechanisms in response to the fungus infection, including a strong production of lignin and callose deposition to strengthen the cell wall, burst of reactive oxygen species, accumulation of defene hormones, expression of defense-related genes, and target-directed strategies like cross-kingdom RNAi for specific virulent gene silencing. This review summarizes the recent progress made over the past two decades in understanding the interactions between cotton plant and the pathogen Verticillium dahliae during the infection process. The review also discusses the achievements in the control practices of cotton verticillium wilt in recent years, including cultivation practices, biological control, and molecular breeding strategies. These studies reveal that effective management strategies are needed to control the disease, while cultural practices and biological control approaches show promising results in the future. Furthermore, the biological control approaches developed in recent years, including antagonistic fungi, endophytic bacteria, and host induced gene silencing strategies provide efficient choices for integrated disease management.