bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas-Liquid Separator Modified on CV-AAS System for Determination of Total Hg in the Industrial Wastewater Samples
Authors: Sujito Sujito , Pasaribu Subur P , Wirawan Teguh , Panggabean Aman Sentosa
Published: December 2022

The research about the utilization of modified gas-liquid separators in the determination of Hg ions by using the Cold Vapor Atomic Absorption Spectrophotometer (CV-AAS) method has been done. To optimize the measurement results, several parameters that affect the hydride generator have been studied. Some specified essential parameters are the type and concentration of acid, the level of SnCl2 as a reducing agent, sample volume and the analytical performance such as linearity (r), detection limit (LOD) and quantitation limit (LOQ), repeatability (% RSD), and accuracy have been studied. The results of the research showed the gas-liquid separator modified can be used instead of commercial gas- liquid separators. It was showed by the repeatability value as % RSD < 2/3 CV Horwitz values, the LOD was 0.2530 μg/mL, and the LOQ was 0.8432 μg/mL. The accuracy of this method was good shown by a recovery percentage of 101.6%. Based on the result of this research, the modified of gas-liquid separator can be used for the determination of Hg ions by using the CV-AAS method with valid results
Levels of Cortisol and Inflammatory Cytokines after The Induction of Various Sleep Deprivation Stress Models in Male Wistar Rats
Authors: Arjadi Fitranto , Wisesa Sindhu , Inayani Nor Sri , Kuncoro Prasetyo Tri , Widiartini Catharina
Published: December 2022

Sleep deprivation (SD) can modulate the production of various cytokines, including pro-inflammatory cytokines such as IL-6, TNF-α, and IFN-γ, and anti-inflammatory cytokines such as IL-10. Paradoxical sleep deprivation (PSD) increases the risk of inflammation but can be relieved by sleep recovery (SR). This study aimed to determine the differences in levels of cortisol and inflammatory cytokines (IL-6, IL-10, TNF-α, dan IFN-γ) in male Wistar rats (Rattus norvegicus) after induction of various sleep deprivation stress models. Twenty-five of male Wistar rats were randomly divided into five groups: control, PSD (20 hours of SD/day for five days), Total Sleep Deprivation or TSD (24 hours of SD/day for five days), PSD+SR (PSD followed by SR), and TSD+SR (TSD followed by SR). The plasma cortisol levels were measured with ELISA, and inflammatory cytokine levels were measured with immunoassay and calculated with fold change. Mean cortisol levels were significantly increased in treatment groups compared to the control group (p=0.029). Multivariate analysis showed no statistically significant difference in inflammatory cytokine levels of IL-6 (p=0.658), IL-10 (p=0.065), TNF-α (p=0.399), and IFN-γ (p=0.283) in all groups. In conclusion, various sleep deprivation stress models affect cortisol levels but not inflammatory cytokine levels of IL-6, IL-10, TNF-α, and IFN-γ among male Wistar rats.
Carbon-Oxalate (C-Ox) Practicum Waste as an Adsorbent Material Candidate in the Chemistry Laboratory
Authors: Lasia I Ketut
Published: December 2022

This study aims to treat carbon and oxalate practicum waste as an adsorbent material candidate in the Chemistry Laboratory. Practicum waste was used to synthesise carbon-oxalate (C-Ox) by using wet (C-OxW) and semi-wet (C-OxDs) impregnation methods. The products were tested by SEM and FTIR. The adsorption was tested by contacting each 1 gram of C-Ox with various concentrations of chromium ions waste for 24 hours while shaking. The filtrate was measured by AAS. The data obtained were compared with standard activated carbon (CC) as control and analyzed with Freundlich and Langmuir isotherm equations. The results showed that C-Ox can be used as an adsorbent in the chemistry laboratory. Based on the SEM test, the pores of C-OxW were seen to be most than C-OxDs and CC. Adsorption of chromium ions of C-OxW and C-OxDs were more effective than CC. C-Ox test by FTIR showed very sharp wavenumbers appeared at 3674.5 and 3705.41 cm-1 for the hydroxyl groups; 1697.4 cm-1 for C=O; and 1141.8 cm-1 for C-O. The determination coefficient (R2) of Freundlich isotherm of CC and C-Ox were higher than Langmuir isotherm, and on the other hand, R2 of C-OxDs was shown oppositely.
Analisis Segmentasi Sel Darah Merah berbasis Mask-RCNN
Authors: Tyas Dyah Aruming , Ratnaningsih Tri
Published: December 2022

Pengembangan Computer-aided diagnosis (CAD) pada bidang patologi klinik memiliki tantangan tersendiri. CAD pada bidang patologi klinik diharapkan dapat membantu proses pengamatan laboratorium. Salah satu tantangan pengembangan CAD tersebut adalah pada proses segmentasi sel darah merah. Segmentasi sel darah merah yang menempel biasanya menimbulkan kesalahan segmentasi berupa bentuk sel tidak utuh atau sel sama sekali tidak tersegmentasi. Kesalahan segmentasi akan berakibat pada kesalahan pengenalan jenis sel darah sehingga diperlukan metode yang tepat untuk proses segmentasi. Oleh sebab itu, penelitian ini berfokus untuk menganalisis hasil segmentasi sel darah merah yang diperoleh menggunakan arsitektur model Mask-RCNN. Variasi parameter detection min confidence dilakukan untuk melihat dampaknya pada hasil segmentasi. Berdasarkan hasil penelitian diperoleh bahwa akurasi hasil segmentasi terbaik adalah 91,24% yang berasal dari model Mask-RCNN dengan nilai parameter detection min confidence = 0,7. Pada model tersebut, baik sel darah merah tunggal ataupun sel darah merah yang saling menempel dapat disegmentasi dengan baik.
Comparative Analysis of Financial Performance between Companies in the Oil and Gas Trading Industry in 2019-2021
Authors: Yuliatin Binti , Nidan Paramesti Paramita , Nuraini Putri , Indriyati Lisa
Published: December 2022

This research was conducted with the aim of knowing how to compare the financial performance of the oil and gas trading industry with cross-sectional analysis techniques. The type of research conducted in this research is qualitative research with research objects at several companies, namely PT Radiant Utama Interinsco Tbk, PT Elnusa Tbk, PT AKR Corporindo Tbk, and PT Aneka Gas Industri Tbk. The data used in this study comes from secondary data, namely the internet in the form of company financial reports for the 2019-2021 period obtained from the Indonesia Stock Exchange. The results of this study indicate that PT Radiant Utama Interinsco Tbk has the best financial performance on inventory turnover ratio and average age, PT Elnusa Tbk has good inventory performance on current ratio, quick ratio, DAR, and DER., PT AKR. Corporindo Tbk has performed well on the ratios of TIE, FCC, Dividend Payout, Dividend Yield, and PER. PT Aneka Gas Industri Tbk has performed well on the ratio of Receivables Turnover Ratio and Average Age of Receivables.
Pioneros de la modernidad en Ciudad Juárez
Authors: Peña Barrera Leticia
Published: December 2022

En este trabajo me refiero descriptivamente al momento histórico en que se construyó la Capilla del Seminario Conciliar de Ciudad Juárez y a quienes, tanto obispo como arquitecto, supieron interpretar los cánones de la reforma de la iglesia que se gestaba para construir un ícono arquitectónico moderno. Se hace reconocimiento a aquellas personas que contribuyeron, a través de su visión, a definir edificaciones relevantes en el campo de la modernidad y que se adelantaron a su tiempo: el arquitecto Óscar Sánchez Cordero, el Ing. Adolfo Álvarez como constructor y el Obispo Don Manuel Talamás Camandari.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 26.11.2022 г. по 2.12.2022 г.
Authors: Дмитриева Людмила
Published: December 2022

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 вызывающих озабоченность (VOC), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 26.11.2022 г. по 2.12.2022 г.
Diseño del Sistema de Control Interno en la Gestión de Inventarios en la empresa Aya Plus E.I.R.L., San Borja – 2022
Authors:   , Cárdenas Cosavalente Susan Rut , Quintano Huaccache Janeth Nelly
Published: December 2022

La presente investigación lleva por título “Diseño del Sistema de Control Interno en la Gestión de Inventarios en la empresa Aya Plus E.I.R.L., San Borja – 2022”, presentó como finalidad describir de qué manera el Diseño del Sistema de Control es un referente en la Gestión de Inventario de la empresa Aya Plus E.I.R.L., Distrito de San Borja-2022. La muestra en estudio estuvo conformada por 37 trabajadores, la investigación fue de diseño no experimental, con enfoque cuantitativo de tipo descriptivo. Se concluye que el Diseño del Sistema de Control es un referente en la Gestión de Inventario de la empresa Aya Plus E.I.R.L., Distrito de San Borja-2022. Contar con el entorno de control, la evaluación del riesgo, las actividades de control, la información y comunicación y la supervisión adecuada y oportuna impactarán considerablemente en la gestión de inventario.
Microstrip Patch antenna for Wi-Fi and 5G based on MUC
Authors: Nelaturi Suman
Published: December 2022

This communication presented the patch antenna functioning at Wi-Fi and 5G bands. To get compactness the side lengths of the patch are calculated with reference to upper-frequency band (3.5 GHz). Lower band (2.4 GHz) is obtained by loading the Mushroom Unit Cell (MUC) along the bottom right corner of the patch. To attain circular polarization (CP) at 5G band the edges of the patch are replaced with Koch fractal curves. This blend of the Double Negative Transmission Lines metamaterials (DNG TL), as well as fractal concepts yielded good compactness suitable for ultra-thin portable gadgets. Measured results have good correlation with simulated data from HFSS. The achieved bandwidths at the lower and upper bands are 2.4% and 5.6%. CP bandwidth of the proposed antenna at 5G band obtained from the measured data is 2.2%.
DE-GWO: A Multi-objective Workflow Scheduling Algorithm for Heterogeneous Fog-Cloud Environment
Authors: Shukla Prashant , Pandey Sudhakar
Published: December 2022

The demand for a quick response from cloud services is rapidly increasing day-by-day. Fog computing is a trending solution to fulfil the demands. When integrated with the cloud, this technology can tremendously improve the performance. Like any other technology, Fog also has the shortcoming of limited resources. Efficient scheduling of tasks among limited resources is one of the significant issues for research. This paper proposes a multi-objective hybrid task scheduling algorithm named Differential evolution-Grey wolf optimization (DE-GWO), which combines Differential evolution (DE) and Grey wolf optimization (GWO) approach to address the workflow scheduling issue. The proposed algorithm is applied on five different scientific workflows (Montage, Epigenomics, SIPHT, LIGO and Cybershake) and evaluated on three performance indicators (execution time, energy consumption and cost). The DE method is chosen as the evolutionary pattern of wolves to speed up convergence and enhance GWO's accuracy. Simulation results show that the DE-GWO performs better than the other traditional and recently proposed optimization algorithms, since DE incorporates evolution and elimination mechanisms in GWO and GWO retains a good balance between exploration and exploitation.
The mechanism for transferring the impact of the deficits and surpluses in the public budget to the balance of payments
Authors: ISMAEL HEWA OTHMAN
Published: December 2022

The purpose of this paper is to clarify how the general budget's (surplus or deficit) impacts diverse sorts of economic activity both inside and outside the nation, including the balance of payments as one of the key economic indicators to comprehend a nation's economic reality with other nations. Numerous studies have been conducted at various levels and for various economies in light of the general budget's significance in economic life and the impact it has on numerous economic variables, particularly the balance of payments. This study differs in several ways from previous studies in that it builds its approach on the idea of linking strategies for dealing with the balance of payments with the public budget and the use of a presentation of that relationship through many equations and illustrative charts. The study supports the research hypothesis through descriptive analysis.
Reswitching and Labor Market Rigidity: New Results with Empirical Implications from a Classical Growth Model
Authors: Elmslie Bruce , Sedgley Norman
Published: December 2022

We demonstrate a new result regarding reswitching within a classical growth framework. The question of reswitching comes down to a question of factor market substitutability. The assumption of full employment due to a wage adjustment mechanism eliminates a perverse switch point as a stable equilibrium outcome. Implications for future empirical work on reswitching and perverse switches are explored.
JEL CODES: 04, B23
Right ventricular pacing is not harmful as perceived previously
Authors: Elkholy Doaa , Nawar Mostafa , Abdelhay Ayman , Rafla Samir
Published: December 2022

Background: Pacing from the apex of the RV is not optimal. This study aimed to assess and compare RV and LV pacing of LV function and dyssynchrony.
Thirty-six patients who presented with indications for pacemakers were studied. We divided them into three groups: 12 had LV pacing (lead was inserted from coronary sinus to lateral vein, the same procedure used in resynchronization pacing); 12 had RV pacing group (apical pacing only, not septal or outflow). Twelve had Dual-chamber pacing. Control group: Twelve healthy participants were included in this study.
Results: During the post-implantation period, the distance of the 6-MWT improved significantly, P= 0.006. Cardiac output (COP) during the preimplantation period and at the six-month follow-up (P= 0.003). The IVT (isovolumic time) variables at six months' pre- and post-implantation periods (P= 0.005). LV pacing group: The comparison of the 6-MWT distance and the quality of life (QOL) score in the post-implantation period and at six months revealed a highly significant difference (improvement) as well as in the median values of the PAP (RAP = Right atrial pressure), COP, MPI (MPI = myocardial performance index), IVT, and Z (Z ratio = sum of the left ventricular ejection and filling times divided by RR interval) (P= 0.000).
Conclusions: RVP seems to have fewer detrimental effects on LV synchrony and LV function. For those patients indicated for conventional pacemaker indications with normal or mildly impaired LV function with EF > 35%, RVA (right ventricular apical) pacing is still the gold standard pacing site.
Pollution and Risk Assessment of Phenolic Compounds in Drinking Water Sources in South-Western Nigeria
Authors: Otitoju Oluwaferanmi , Alfred Moses , Ogunlaja Olumuyiwa , Olorunnisola Chidinma , Olukanni Olumide , Ogunlaja Aemere , Omorogie Martins , Unuabonah Emmanuel
Published: December 2022

This study reports the occurrence and risk assessment of 2,4- Dinitrophenol (2,4-DNP), Phenol (PHE), and 2,4,6- Trichlorophenol (2,4,6-TCP) in drinking water sources in three South western States in Nigeria (Osun, Oyo and Lagos). Groundwater (GW) and surface water (SW) were collected during dry and wet seasons of a year. The detection frequency of the phenolic compounds followed the trend: Phenol > 2,4-DNP > 2,4,6- TCP. The mean concentrations of 2,4-DNP, Phenol, and 2,4,6-TCP in GW/SW samples from Osun State were 639/553 µg L− 1, 261/262 µg L− 1, and 169/131 µg L− 1 respectively, during the rainy season and 154/7 µg L− 1, 78/37 µg L− 1, and 123/15 µg L− 1 during the dry season. In Oyo state, the mean concentration were 165/391 µgL− 1 for 2,4-DNP and 71/231 µgL− 1 for Phenol in GW/SW samples respectively, during rainy season. Generally, in the dry season, these values decreased. In any case, these concentrations are higher than those previously reported in water from other countries. The concentration of 2,4-DNP in water posed serious ecological risks to Daphnia on the acute scale while it was Algae on the chronic scale. Estimated daily intake and hazard quotient calculations suggests that 2,4-DNP in water pose serious toxicity concern to humans. Additionally, the concentration of 2,4,6-TCP in water from Osun State in both seasons pose significant carcinogenic risk to persons ingesting water from this State. Every exposure group were at risk from ingesting these phenolic compounds in water. However, this decreased with increasing age of the exposure group. Results from the Principal Component Analysis indicate that 2,4-DNP in water samples is from an anthropogenic source different from that for Phenol and 2,4,6-TCP. There is a need to treat these GW and SW before drinking while maintaining regular assessment of these water sources.
Needs assessment of informal caregivers supporting a person with dementia: a descriptive study of current practices
Authors: Pasquier Noémie , Pihet Sandrine , Carrard Isabelle
Published: December 2022

Background
Informal caregivers who support a person with dementia (ICDs) play an essential role in the healthcare system. Their intensive contribution puts them at high risk of negative consequences on their physical and psychological health. Despite significant unmet needs, ICDs rarely or only belatedly ask for support. Identifying these unmet needs is essential for a timely use of the relevant support services and for the prevention of exhaustion. Research about how diverse support providers assess the needs of ICDs is scarce. Our study aimed to describe current evaluation practices of support providers regarding needs assessment in one Swiss canton (province), in order to identify strengths and weaknesses.
Methods
A survey was completed by 55 professionals and volunteers involved in ICDs support with six open-ended and four closed questions investigating current practices for assessing the needs of ICDs.
Results
A diversity of providers assessing the needs of ICDs reported spending on average 45 minutes per assessment (range: 5-120 minutes). Most providers declared that they were reassessing the needs of ICDs (80%) and in most cases ICDs received some feedback after the assessment (86.5%). Few providers used a systematic procedure focused on ICDs (27.1%), and no validated tool with a focus on the needs of ICDs was used. Only 52.7% of providers reported having been trained in needs assessment. 41.8% described heterogeneous assessment procedures in their service, and the collected information was mostly stored in files related to the person with dementia (PwD) and not in a file directly attributed to the ICD.
Conclusion
Current practices in assessment of the needs of ICDs maintain the lack of coordination within the fragmented network of support providers, highlighting the need for policy thinking along the ICDs trajectory. As a first step towards improvement, providers need a cross-professional tool that allows for systematic and exhaustive assessment focused on the needs of ICDs.
Highly Efficient Regulation Strategy of Fluorescence Emission Wavelength via Designing the Structure of Carbon Dots
Authors: bai haiyan , Jin Xilang , Cheng Zhao , Zhou Hongwei , Wang Haozhe , Yu Jiajia , Zuo Jialing , Chen Weixing
Published: December 2022

Multicolor carbon dots (CDs) possess tremendous potential applications, especially in optoelectronic devices. However, further applications of multi-color LED have been constrained due to the very limited researches concerning the wavelength control mechanism of multi-color CDs. In this work, through theoretical calculation and experimental verification, the regulatory effects of sp2 conjugated domain on the fluorescence wavelength of CDs were explored. Firstly, through a regulation on the structure size and the introduction of amide bonds, four kinds of structures were designed in DFT theoretical calculation to explore the influence of sp2 conjugated domain on the fluorescence wavelength of CDs theoretically. Then, using thiourea and p-phenylenediamine as the precursors and by regulating the reaction solvents, multicolor CDs with blue, green and red fluorescence emission were prepared to experimentally verify the emission mechanism. It was confirmed that the increasing structure size and the introduction of amide bond would induce an increasing size of the sp2 conjugated domain, leading to the red shift of the CDs fluorescence wavelength. Finally, in order to suppress the self-quenching performance, the CDs@PVP fluorescent film possessing bright solid-state fluorescence was constructed for a better application in light-emitting diodes. The approach provided an effective strategy to realize the programmed regulation on the fluorescence wavelength of CDs, offering us full of potentials for the applications of CDs in the photoelectric device fields.
Prognosis of Neuromyelitis Optica Spectrum Disorders: Differences Between Han Chinese and Tibetans, a retrospective cohort study
Authors: Luo Wenqin , Wang Xiaofei , Shi Ziyan , Kong Lingyao , Chen Hongxi , Lang Yanlin , Du Qin , Cai Linjun , Zhou Hongyu
Published: December 2022

Purpose
To investigate the demographic characteristics and prognosis of Tibetan and Han Chinese patients with optic neuromyelitis Optica spectrum disorders (NMOSD).
Methods
From January 2015 to January 2022, 860 NMOSD patients were in our database. The demographic and clinical characteristics were described and retrospectively analyzed. In the subsequent analysis, we used 2 methods to eliminate confounding: a 1:3 propensity score matching (PSM) was performed and univariable cox regression was used to analyze the effect of ethnicity to prognosis; besides, univariable and multivariable cox regression was performed in the original cohort to explore the relationship between ethnicity and disability. The risk of relapse, severe attack, visual disability, motor disability and total disability in different races were analyzed.
Results
This study included 406 NMOSD patients (25 Tibetans and 381 Han), with a mean onset age of 40 ± 40 years, an 89% female population, and a median disease duration of 50 months. The most affected areas were the optic nerve (48%) and spinal cord (76%), no Tibetans developed area postrema syndromes (APS). 322 (79%) patients suffered at least 1 relapse, 156 (38%) suffered severe attack, 60 (15%) and 47 (12%) patients developed permanent visual and motor disability respectively. The total rate of disability was 23% (98 patients). Results from both methods showed a higher risk of severe attack, visual disability, and total disability in Tibetan, but the risk of relapse and motor disability did not differ between races.
Conclusions
our study demonstrated that compared with Han Chinese, Tibetans show a higher risk of disability.
Network pharmacological study of ethyl acetate fraction of Ophioglossum vulgatum Linn. in alopecia treatment
Authors: Zhu Lijian , Lai Yahui , Du Haoran , Li Hailong , Ding Bin
Published: December 2022

Background
Ophioglossum vulgatum Linn. (O. vulgatum) is a herbal medicine of southwest provinces in China, which has been used for treatment of varieties diseases including wound or alopecia since ancient time. However, few of its pharmacological and pharmacochemical knowledge was known.
Methods
The ethyl acetate fraction of O. vulgatum (OpvE) was prepared with the reflex extraction and fractional extraction method. And the components in this fraction were identified with UPLC-Q/TOF-MS system and SCIEXOS database. The potential functions and regulatory pathways of these components were screened and predicted with some bioinformatic methods. MTT was engaged to determining the cell proliferation. Spectrophotometric method was carried according to the respond kits menus to identifying the ATP concentration and catalase activity. The transcription of the genes was semi-quantitatively studied by real-time PCR.
Results
The extract ratio of OpvE was 1.67 ± 0.78% (g/g). 24 Ingredients were identified, of which 12 compounds were found with positive and negative model of UPLC-Q/TOF-MS. 409 Candidate targets were obtained with bioinformatic analysis. And 14 pathways were selected with KEGG analysis (P < 0.05) as criterion. Finally, the cell proliferation promoting activity of OpvE (0.98–125 µg/mL) were determined with HaCaT cell assays in vitro. 250 µg/mL OpvE showed cell toxicity. In addition, the ATP concentration and catalase (CAT) activity were increased with additional OpvE treatment (7.5–15 µg/mL for ATP and 30–60 µg/mL for CAT). Transcription of type Ⅰ collagen pro-α1 chain (COL1A1) fibronectin-1 (FN1), and tumor necrosis factor (TNF-α) were also increased in cell assays with 15, 30 and 60 µg/mL OpvE respectively.
Conclusion
OpvE was identified as a hair growth promoting activity herbal, providing a new potential herbal medicine for the treatment of alopecia.
Why are some outbreaks worse than others? COVID-19 outbreak management strategies from a PHU perspective
Authors: Hodge Emma , Oversby Shannen , McClure Roderick , Chor Josette
Published: December 2022

Background: From a Public Health Unit (PHU) perspective, this review aimed to examine factors associated with adverse outbreak outcomes, to identify evidence based focal strategies of managing COVID-19 outbreaks in aged care settings.
Methods: A retrospective review of PHU documentation identified 55 COVID-19 outbreaks in aged care facilities in Wide Bay during 2022.
Results: Thematic analysis using the framework approach identified several themes and subthemes associated with COVID-19 outbreaks in aged care. These were analysed for statistical significance against outbreak outcomes including duration, attack rate and case fatality rate. There was a significant relationship between memory support unit (MSU) involvement and adverse outbreak outcomes. Attack rate was significantly affected by communication efficiency, case detection and staff cohorting. Staff shortages were also significantly associated with adverse outcomes regarding attack rate and duration.
Conclusions: This emphasises the importance of frequent communication between PHUs and RACFs during an active outbreak, as well as the need for prompt case detection, to minimise viral transmission, staff shortages and cohorting are also crucial factors to be addressed during outbreak management.
Implications for Public Health: This review adds to the evidence basis of COVID-19 outbreak management strategies to improve PHU advice to RACFs during future periods of viral transmission, to ultimately reduce the associated burden of disease.
Community capacity for prevention and health promotion: a systematic review on underlying domains and assessment methods
Authors: Birgel Vera , Decker Lea , Röding Dominik , Walter Ulla
Published: December 2022

Background
Community capacity is defined as the characteristics of communities that affect their ability to identify and address social and public health problems. Building community capacity has developed into a well-recognized health promotion approach. Despite general agreement about certain capacity domains and frameworks, there is no comprehensive and consistent assessment of community capacity. The aim of this review is to identify a) domains and b) methods used to assess community capacity related to community-based prevention and health promotion.
Methods
A systematic search was performed on 06-01-2022 via PubMed, Web of Science, and Science Direct, with supplemental searches via Google Scholar. Studies in English, from 1990 to 2022, that explicitly described how community capacity was assessed in health promotion and prevention interventions, were included. Furthermore, studies had to meet at least two of the three following criteria for capacity assessment: a theoretical foundation, a participatory approach, or a field test of the assessment tool. From 3,086 records, after exclusion criteria were applied, 38 studies were included. Nineteen studies used mixed, eleven qualitative and eight quantitative methods. The various domains to assess community capacity were identified and reassembled into nine comprehensive domains: community participation, knowledge and skills, resources, leadership, community power, sense of community, collaboration, critical awareness and problem-solving, and community structure. Additionally, four sub-domains were found: commitment, communication, shared values and goals, and sustainability.
Discussion
This review provides an overview of community capacity domains and assessment methods, thus facilitating the development of a comprehensive approach to capacity assessment in future research.
BLTR1 is decreased in steroid resistant pro-inflammatory CD28nullCD8+ T lymphocytes in patients with COPD - the spillover hypothesis explained?
Authors: Hodge Greg , Jersmann Hubertus , Holmes Mark , Asare Patrick , Roscioli Eugene , Reynolds Paul N. , Hodge Sandra
Published: December 2022

Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs of both smokers and COPD patients but also in the peripheral circulation in COPD. The reason for this is unclear but has been described as a spillover from cells in the lungs that may cause the systemic inflammation noted in COPD. We have recently shown an increase in steroid resistant CD28nullCD8+ senescent lymphocytes in the lungs and peripheral blood in COPD. Leukotreine B4 (LB4) receptor 1 (BLTR1) is involved in recruitment of CD8+ T cells to sites of inflammation and we hypothesized may be involved in migration of these senescent lymphocytes from the lungs in COPD.
Methods: BLTR1, GCR, IFNγ and TNFαexpression were measured in peripheral blood, BAL and large proximal and small distal airway CD28± CD8± T and NKT-like cells from COPD patients and healthy control subjects (± prednisolone) following in vitro stimulation using flow cytometry and western blot. Chemotaxis of leucocyte subsets was determined (± LB4 ± prednisolone).
Results: There was an increase in BLTR1-CD28nullCD8+ lymphocytes in the lungs and blood in patients with COPD compared with controls. BLTR1- CD28null CD8+ T and NKT-like cells produce more IFN/TNF than BLTR+ cells and fail to migrate to LTB4. Treatment with 1µM prednisolone in vitro resulted in upregulation of BLTR1 expression in pro-inflammatory CD28nullCD8+ cells and migration to LB4.
Conclusions: Loss of BLTR1 is associated with an increased inflammatory potential of CD28nullCD8+ T cells and may allow these pro-inflammatory steroid resistant cells to migrate to peripheral blood. Treatment strategies that upregulate BLTR1 may reduce systemic inflammation and associated co-morbidity in patients with COPD.
Perfusion parameters predict pathology and mutation status in lung cancer brain metastases based on CT imaging: a pilot study
Authors: Jiang Chuncheng , Liu Xin , Qu Qianqian , Jiang Zhonghua , Wang Yunqiang
Published: December 2022

Objectives
To define the pathological subtype and mutational status of metastatic disease in patients with non-small cell lung cancer (NSCLC) using CT imaging-based perfusion parameters analysis of brain metastatic lesions.
Methods
We retrospectively identified NSCLC patients with brain metastases who got treatment in our hospital during 2019 to 2021 and had their underlying lung cancer pathologically and genotypically tested. CT perfusion images of the brain were utilized to segment enhancing tumors and peritumoral edema, as well as extract CT perfusion parameters. The most relevant perfusion parameters were identified to classify the pathological subtype and mutation status. Squamous cell carcinoma was found in 15 of the 45 patients in the research cohort (mean age 66.29 ± 9.98 years; M: F = 26:19), while adenocarcinoma was found in 30. In addition, 19 had an epidermal growth factor receptor (EGFR) mutation, and 11 had an EGFR wild-type. After admission, all patients were subjected to a CT perfusion imaging examination. The differences in CT perfusion parameters between different pathological subtypes and mutational status were analyzed. The receiver-operating characteristic (ROC) curve was used to predict the pathological subtype and mutational status of the metastasis.
Results
Among the quantitative parameters, CBF and MTT were significantly different between the two lung cancers, as well as the two mutational statuses (adenocarcinoma vs. squamous cell carcinoma: P < 0.001, P < 0.001.EGFR mutation vs. EGFR wild-type: P < 0.016, P < 0.046.). For classification of pathological subtype, EGFR mutation status, the model developed with both CBF and MTT resulted in area-under-the-curve (AUC) values of 0.849 and 0.790, respectively.
Conclusions
Perfusion parameters analysis of brain metastases using CT imaging in patients with primary lung cancer could be used to classify pathological subtype and mutational status. This method might be beneficial for developing treatment plans and determining prognosis.
In silico analysis of NHP2 membrane protein, a novel vaccine candidate present in the RD7 region of Mycobacterium tuberculosis
Authors: Kootery Kaviya Parambath , Sarojini Suma
Published: December 2022

Mycobacterium tuberculosis, the etiological agent of tuberculosis, is one of the most tricky pathogens. We have only a few protective shields, like the BCG vaccine against the pathogen, which itself has poor efficacy in preventing adult tuberculosis. Even though different vaccine trials for an alternative vaccine have been conducted, those studies have not shown much promising results. In the current study, advanced computational technology was used to study the potential of a novel hypothetical mycobacterial protein, identified by subtractive hybridization, to be a vaccine candidate. NHP2 (Novel Hypothetical Protein 2), housed in the RD7 region of the clinical strains of M. tuberculosis, was studied for its physical, chemical, immunological and structural properties using different computational tools. PFAM studies and Gene ontology studies depicted NHP2 protein to be functionally active with a possible antibiotic binding domain too. Different computational tools used to assess the toxicity, allergenicity and antigenicity of the protein indicated its antigenic nature. Immune Epitope Database (IEDB) tools were used to study the T and B cell determinants of the protein. The 3D structure of the protein was designed, refined and authenticated using bioinformatics tools. The validated tertiary structure of the protein was docked against the TLR3 immune receptor to study the binding affinity and docking scores. Molecular dynamic simulation of the protein-protein complex formed were studied. NHP2 was found to activate host immune response against tubercle bacillus and could be explored as a potential vaccine in the fight against tuberculosis.
Assessment of Farmers’ Perception on Potato Farming Systems
Authors: Momina  , Tesfaye  , Wallelign  , Tadele
Published: December 2022

Assessment of farmers’ perception on potato farming systems was carried out with the main objective of investigating the perception of farmers’ on potato (Solanum tuberosum L.) in the farming systems in north western Ethiopia. Secondary and primary sources of data were collected. 9.8% farmers went through off farm activities. They had an average potato production experience, livestock number and farm size of 36.81 years, 5.17 and 1.63ha, respectively. These farmers allot on average 0.47 ha (28.83%) of their land for potato production. The dominant potato growing season was the main season (65.1%), followed by irrigation season (25.7%) and with residual moisture (9.2%). 16.6% produced potato used as seed, 48.55% for household consumption and 25.73% sold in the near bye market with very low price (2.17 Birr/kg) as income source. On average there were two commonly grown varieties per farmer. They were losing such local potato varieties which had different quality attributes to be used in different breeding/agronomy programmes and best fit to degraded lands. Farmers ploughed their land 3.34 times before planting potato and used 2.13 t/ha potato seeds at planting as seed rate. 14.4% used their own seeds, 73.5% purchased from the surrounding market, 10.2% from their neighbors and 1.9% from the agricultural offices. Most farmers (63.0%) used fertilization, crop rotation mainly with potato (35.1%) and terracing technique (1.9%) as traditional technique of soil fertility management. Generally, farmers in the surveyed area believed that potato can ameliorate the soil fertility and protect their soils from erosion. Researches should be conducted to minimize number of ploughing in potato production. NGO’s, GOs and universities should take responsibilities to multiply and disseminate improved potato seeds and in the conservation of important local varieties. Trainings should also be given to farmers on production and usage of certified potato seeds on potato production.
The regenerative role of mast cells and mesenchymal stem cells in histopathology of sciatic nerve and tibialis cranialis muscle, following denervation in rats
Authors: Bakhtiary Zahra , Shahrooz Rasoul , Hobbenaghi Rahim , Azizi Saeed , Soltanalinejad Farhad , Khoshfetrat Ali Baradar
Published: December 2022

Atrophy of the leg muscles following sciatic nerve transection can lead to the death of myofibers. The aim of this study was to evaluate the process of nerve and muscle regeneration using mast cells and mesenchymal stem cells.
In this study, 90 adult male Wistar rats weighing 150-200g were randomly divided into six main groups (n=15) and each group into three subgroups (2, 4 and 8 weeks, n=5). Groups: control; without surgery, transection (Tr); Fixing the two ends of the transected sciatic nerve (8 mm gap) in silicone tube, scaffold (S); Put collagen gel inside the silicone tube, mast cell (MC); Placed 3×104 mast cells mixed with scaffold, mesenchymal stem cell (MSC); Placed 3×104 mesenchymal stem cells mixed with scaffold, and mast cell-mesenchymal stem cell (MC+MSC); 3×104 of each of the mast cell and mesenchymal stem cells along with scaffold. Animals euthanized and sampled at weeks 2, 4 and 8 for muscle and nerve histological and nerve immunohistochemistical evaluations.
Histomorphometric evaluation results of tibialis cranialis muscle (TCM) included: diameter of muscle fibers, ratio of the muscle fiber’s nuclei to the fibrocyte nuclei (mn/fn), ratio of the muscle fibers nuclei number to the muscle fiber’s number (mn/mf) and ratio of the blood vessels number to the number of muscle fibers (v/mf) in all treatment groups, especially the MC + MSC group, increased compared to the Tr group but the number of mast cells, the percentage of sarcoplasmolysis and necrosis fibers dramatically decreased. Histomorphometric evaluation results of the nerve in its various parts and immunohistochemistry results also showed improve nerve conduction in all groups, especially the MC + MSC group compared to the Tr group. All results were time dependent and in most cases at 8th week were better the other times. Overall,
the results of this study showed that the simultaneous use of MCs and MSCs, especially in the eighth week, accelerated the healing of the sciatic nerve and TCM following reinnervation.
Turkish version of the new instrument for Orthorexia Nervosa -Test of Orthorexia Nervosa (TON-17): a validity and reliability study
Authors: Yassibas Emine , Ayyıldız Feride
Published: December 2022

Background There are several scales to evaluate orthorexia nervosa (ON), a pathological obsession, fixation or preoccupation with healthy foods. However, studies report that some of these scales have poor internal consistency and some do not have test-retest reliability, therefore new scales are needed to evaluate ON correctly. This study aims to adapt the Test of Orthorexia Nervosa-17 (TON-17) into Turkish and verify its validity and reliability. Methods The study included a total of 539 adults, 131 men (24.3%) and 408 women (75.7%), with a mean age of 30.2 ± 12.26 years. A reliability analysis was performed and a confirmatory factor analysis (CFA) to test its construct validity. Time invariance of the scale was examined by test-retest analysis, and its convergent validity was evaluated by a correlation analysis conducted to test relationships between the scale and other theoretically relevant instruments (EAT-26 and OBQ-9). Analyses were conducted using SPSS Version 23 and the AMOS program. Results The Cronbach's α internal consistency coefficient of the total scale was found to be 0.820, suggesting a strong internal consistency. The Cronbach's α values of its factors were 0.681 for the Factor 1, 0.643 for the Factor 2, and 0.726 for the Factor 3. In addition, the test-retest reliability was found as 0.868 for the total scale, suggesting an excellent reliability. The most of fit indices (CMIN/df, RMSEA, AGFI, NFI and TLI) of the scale were acceptable, and the GFI indicated a good model fit. Conclusion This study has shown that the Turkish version of TON-17, which is a new tool with three-factor structure to evaluate both healthy and unhealthy orthorexia, is valid and reliable scale. Studies of TON-17 on diverse cultures will contribute to the literature. Therefore, examining the validity and reliability of TON-17 in diverse cultures and populations may contribute to developing the gold standard scale for evaluating ON in future studies.
Universal properties of non-Hermitian viscoelastic channel flows
Authors: Li Yuke , Steinberg Victor
Published: December 2022

An addition of long-chain, flexible polymers strongly affects laminar and turbulent Newtonian flows. In the laminar inertia-less viscoelastic channel flow, the supercritical elastic non-normal mode instability at finite-size perturbations leads directly to chaotic flow. Then three chaotic flow regimes: transition, elastic turbulence (ET), and drag reduction (DR), accompanied by elastic waves, are observed and characterized. Here we show that independently of external perturbation strength and structure, chaotic flows above the instability onset in transition, ET, and DR flow regimes reveal similar scaling of flow properties with Wi, defined the degree of polymer stretching, stream-wise streaks self-organized into cycling self-sustained process, synchronized by elastic waves, and universal scaling of elastic wave speed with Wi. Moreover, these properties persist over the entire channel length above the instability threshold. It means that only an absolute instability exists in inertia-less viscoelastic channel flows, whereas a convective instability is absent. This unexpected discovery is in a sharp contrast with Newtonian flows, where both convective and absolute instabilities are always present in open flows. It probably transpires due to differences in nonlinear terms in an elastic stress equation, where except an advective term, two key terms describing polymer stretching along the channel length exist.
Food profiling using innovative voltammetric metallic-glassy carbon electrodes evaluated by clustering metrics
Authors: WÓJCIK Szymon , MIRCESKI Valentin , BAŚ Bogusław , JAKUBOWSKA Małgorzata
Published: December 2022

This work proved that the quadruple-disk electrodes - iridium-platinum, platinum-glassy carbon, and iridium-glassy carbon can successfully work as a single sensor and act as voltammetric electronic tongue in food profiling. Current samples obtained with square-wave voltammetry (SWV) were additionally interpreted by a novel technique termed double-sampled differential square-wave voltammetry (DSSWV), which allowed for increasing the resolution and extracting the full, hidden information available in the signals. Four clustering validity indices: Calinski – Harabasz index, Davies – Bouldin index, Silhouette index and gap statistics were applied to select the optimal sensor and the current samples interpretation strategy. These four coefficients indicated the best iridium-platinum electrode combined with overall cathodic potential modulation using the technique of DSSWV. Correct clustering of objects, i.e., samples of five different isotonic beverages from one producer, was confirmed using principal component analysis and polar dendrogram. At the same time, it has been shown that in some variants of measurements and signal interpretation, it is not possible to correctly group the samples.
3D shape reconstruction of the femur from planar X-ray images using statistical shape and appearance models
Authors: Nolte Daniel , Xie Shuqiao , Bull Anthony M. J.
Published: December 2022

Major trauma is a condition that can result in severe bone damage. Customised orthopaedic reconstruction allows for limb salvage surgery and helps to restore joint alignment. For the best possible outcome three dimensional (3D) medical imaging is necessary, but its availability and access, especially in developing countries, can be challenging. In this study, 3D bone shapes of the femur reconstructed from planar radiographs representing bone defects were evaluated for use in orthopaedic surgery. Statistical shape and appearance models generated from 40 cadaveric X-ray computed tomography (CT) images were used to reconstruct 3D bone shapes from digital reconstructed radiographs simulating bone defects between 0% and 50% in anterior posterior (AP) and anterior posterior/medial lateral (AP/ML) directions by comparing the images to projections of the shape model instance. As error metrics for the comparison, measures evaluating the distance between contour lines of the projections as well as a measure comparing similarities in image intensities were used. The results were evaluated using the root mean squared distance for surface error as well as differences in commonly used anatomical measures, including bow, femoral neck, diaphyseal-condylar and version angles between reconstructed surfaces from the shape model and the intact shape reconstructed from the CT image. The reconstructions had average surface errors between 1.59 mm and 3.59 mm with reconstructions using the contour error metric from the AP/ML directions being most accurate. Predictions of bow and femoral neck angles were well below the clinical threshold accuracy of 3°, diaphyseal-condylar angles were around the threshold of 3° and only version angle predictions of between 5.3° and 9.3° were above the clinical threshold, but within the range of accuracies obtained using computer navigation. This study shows that the accuracy of reconstructions combining the use of planar radiographs and statistical shape and appearance models is sufficient for use in orthopaedic reconstruction surgeries.
Boundedness of the Cesàro operator in Dunkl Hardy space * †
Authors: Hu zhuoran
Published: December 2022

Note: Please see pdf for full abstract with equations.
The Hardy space $H_{\lambda}^{p}(\RR^{2}_+)$ associated with the Dunkl transform $\SF_{\lambda}$ and the Dunkl operator $D_x$\,(\,where$D_xf(x)=f'(x)+\frac{\lambda}{x}[f(x)-f(-x)]$\,) is the set of functions $F(x, y)=u(x, y)+iv(x, y)$ on the upper half plane $\RR_+^2=\{(x, y): x\in\RR, y>0\}$ satisfying the $\lambda$-Cauchy-Riemann equations: $D_xu-\partial_y v=0, \partial_y u +D_xv=0$ and $\sup_{y>0}\int_{\RR}|F(x, y)||x|^{2\lambda}dx<0$. In this paper, we will prove that the Ces\`{a}ro operator is bounded in the Dunkl Hardy space $H_{\lambda}^{p}(\RR^{2}_+)$ for every $p\geq\frac{2\lambda}{2\lambda+1},\,\lambda>0$:
where $C$ is a constant depending on $\alpha$, $p$, and $\lambda$. The average function for the Ces\`{a}ro operator $C_{\alpha}$ is $\phi_{\alpha}(t)=\alpha(1-t)^{\alpha-1}$ with $\alpha>0$.
2000 MS Classification: