bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral-Health-Related Quality of Life in Elderly Edentulous Patients with Full-Arch Rehabilitation Treatments: A Systematic Review
Authors: Linn Tin Thinzar , Khaohoen Angkoon , Thu Khaing Myat , Rungsiyakull Pimduen
Published: June 2024

Background: The improvement of oral-health-related quality of life (OHRQoL) with different types of prosthesis for completely edentulous jaws in the elderly population is a critical factor in clinical decision making for these vulnerable patients. This review aims to evaluate the changes in OHRQoL after treatment with different types of full-arch prostheses in the elderly edentulous population to determine the prostheses that result in the greatest improvement in OHRQoL. Materials and Methods: Clinical studies of different types of full-arch prostheses that measured the OHRQoL in edentulous patients 60 years or older were searched for in the PubMed, Embase and Scopus electronic databases, with additional hand searching to summarize the outcomes of the selected studies. Result: Among the 302 identified studies, 10 studies were selected. A total of 504 patients wearing 133 complete dentures, 372 implant overdentures and 39 fixed prostheses were assessed among the selected studies. The overall OHIP and GOHAI scores were evaluated at baseline and in the 3rd, 6th, 12th and 18th months of treatment with the respective prostheses. The improved OHRQoL with overall OHIP scores associated with conventional dentures were 9.21–12.5% from the 3rd month to 1 year after treatment, whereas those associated with implant overdentures and full-arch fixed prosthesis were 9–25.26% at 1 year and 18.53–26.79 at the 18th-month follow-up, respectively. The increased overall GOHAI scores were 21.3–25.43% for conventional dentures, 36.82–41.32% for implant overdentures and 39.48–42.83% for full-arch fixed prosthesis from the 3rd month to the 6th-month follow-up. Conclusion: In general, the improvement in OHRQoL after rehabilitation with implant overdentures declined at one year, and that with full-arch fixed prosthesis declined at the 18th-month follow-up; meanwhile, the OHRQoL associated with conventional dentures improved stably up to one year, but the implant-supported prostheses resulted in an obviously greater improvement in the OHRQoL than that obtained with conventional dentures. However, studies with longer follow-up periods are still required to evaluate the long-term clinical effectiveness.
A Comparison of Different Intensive Care Unit Definitions Derived from the German Administrative Data Set: A Methodological, Real-World Data Analysis from 86 Helios Hospitals
Authors: Bogdanov Christina , Hohenstein Sven , Brederlau Jörg , Groesdonk Heinrich Volker , Bollmann Andreas , Kuhlen Ralf
Published: June 2024

Background: The intensive care unit (ICU) is a scarce resource in all health care systems, necessitating a well-defined utilization. Therefore, benchmarks are essential; and yet, they are limited due to heterogenous definitions of what an ICU is. This study analyzed the case distribution, patient characteristics, and hospital course and outcomes of 6,204,093 patients in the German Helios Hospital Group according to 10 derived ICU definitions. We aimed to set a baseline for the development of a nationwide, uniform ICU definition. Methods: We analyzed ten different ICU definitions: seven derived from the German administrative data set of claims data according to the German Hospital Remuneration Act, three definitions were taken from the Helios Hospital Group’s own bed classification. For each ICU definition, the size of the respective ICU population was analyzed. Due to similar patient characteristics for all ten definitions, we selected three indicator definitions to additionally test statistically against IQM. Results: We analyzed a total of 5,980,702 completed hospital cases, out of which 913,402 referred to an ICU criterion (14.7% of all cases). A key finding is the significant variability in ICU population size, depending on definitions. The most restrictive definition of only mechanical ventilation (DOV definition) resulted in 111,966 (1.9%) cases; mechanical ventilation plus typical intensive care procedure codes (IQM definition) resulted in 210,147 (3.5%) cases; defining each single bed individually as ICU or IMC (ICUᴧIMC definition) resulted in 411,681 (6.9%) cases; and defining any coded length of stay at ICU (LOSi definition) resulted in 721,293 (12.1%) cases. Further testing results for indicator definitions are reported. Conclusions: The size of the population, utilization rates, outcomes, and capacity assumptions clearly depend on the definition of ICU. Therefore, the underlying ICU definition should be stated when making any comparisons. From previous studies, we anticipated that 25–30% of all ICU patients should be mechanically ventilated, and therefore, we conclude that the ICUᴧIMC definition is the most plausible approximation. We suggest a mandatory application of a clearly defined ICU term for all hospitals nationwide for improved benchmarking and data analysis.
Optic Disc Drusen in Pseudoxanthoma Elasticum Are Associated with the Extent of Bruch’s Membrane Calcification
Authors: Raming Kristin , Künzel Sandrine H. , Pfau Maximilian , Hendig Doris , Holz Frank G. , Pfau Kristina
Published: June 2024

Background/Objectives: To assess the frequency, extent, localization and potential progression of optic disc drusen (ODD) and the correlation with the angioid streak (AS) length and retinal atrophy in patients with pseudoxanthoma elasticum (PXE). Methods: This retrospective study included patient data from a dedicated PXE clinic at the Department of Ophthalmology, University of Bonn, Germany (observation period from February 2008 to July 2023). Two readers evaluated the presence, localization, and the extent of the ODD on fundus autofluorescence (FAF) imaging at baseline and the follow-up assessments. Additionally, we measured the length of the longest AS visible at baseline and follow-up and the area of atrophy at baseline, both on FAF. Results: A total of 150 eyes of 75 PXE patients (median age at baseline 51.8 years, IRQ 46.3; 57.5 years, 49 female) underwent retrospective analysis. At baseline, 23 of 75 patients exhibited ODD in a minimum of one eye, resulting in an ODD prevalence of 30.7% in our cohort of PXE patients. Among these, 14 patients showed monocular and 9 binocular ODD that were localized predominantly nasally (46.9%). During the observational period (mean 97.5 ± 44.7 months), only one patient developed de novo ODD in one eye and one other patient showed a progression in the size of the existing ODD. The group of patients with ODD had significantly longer ASs (median 7020 µm, IQR 4604; 9183, vs. AS length without ODD: median 4404 µm, IQR 3512; 5965, p < 0.001). No association with the size of the atrophy was found at baseline (p = 0.27). Conclusions: This study demonstrates a prevalence of ODD of 30.7%. ODD presence is associated with longer ASs (an indicator of the severity and extent of ocular Bruch’s membrane calcification), suggesting that ODD formation is tightly related to ectopic calcification—possibly secondary to calcification of the lamina cribrosa. Prospective studies investigating the impact of ODD (in conjunction with intraocular pressure) on visual function in PXE warrant consideration.
The Morphodynamics of a Double-Crescent Bar System under a Mediterranean Wave Climate: Leucate Beach
Authors: Feyssat Pierre , Certain Raphaël , Robin Nicolas , Raynal Olivier , Lamy Antoine , Barusseau Jean-Paul , Hebert Bertil
Published: June 2024

The morphodynamics of the Leucate double-crescent bar system was studied over twenty years using bathymetric data supplemented by satellite images and video monitoring. Eleven different bar typologies were identified, mostly based on existing beach state classifications (Low-Tide Terrace, Transverse Bar and Rip, Rhythmic Bar and Beach), also including new heterogeneous typologies (TBR/LTT, RBB HP/RBB, TBR/RBB). The inner bar shows greater variability, with 10 different typologies observed, while the outer bar shows only three different typologies. Summer low-energy periods are dominated by TBR/LTT and TBR typologies, while RBB, although common throughout the year, dominates winter periods along with disrupted bar configurations. The return to less energetic periods in spring is associated with the establishment of heterogeneous typologies. The outer bar has a fairly stable position, although breaches at the embayments and slight movements of its horns can occur following particularly energetic episodes. The inner bar, on the other hand, is much more dynamic, with more common breaches at the embayments and significant cross-shore movement of the horns. Seasonal changes in bar typology do not lead to bar renewal through destruction/reconstruction. Overall, the morphological and typological characteristics of the bar system described here seem somewhat unique compared to the existing literature.
Comparative Analysis of Large Language Models in Emergency Plastic Surgery Decision-Making: The Role of Physical Exam Data
Authors: Borna Sahar , Gomez-Cabello Cesar A. , Pressman Sophia M. , Haider Syed Ali , Forte Antonio Jorge
Published: June 2024

In the U.S., diagnostic errors are common across various healthcare settings due to factors like complex procedures and multiple healthcare providers, often exacerbated by inadequate initial evaluations. This study explores the role of Large Language Models (LLMs), specifically OpenAI’s ChatGPT-4 and Google Gemini, in improving emergency decision-making in plastic and reconstructive surgery by evaluating their effectiveness both with and without physical examination data. Thirty medical vignettes covering emergency conditions such as fractures and nerve injuries were used to assess the diagnostic and management responses of the models. These responses were evaluated by medical professionals against established clinical guidelines, using statistical analyses including the Wilcoxon rank-sum test. Results showed that ChatGPT-4 consistently outperformed Gemini in both diagnosis and management, irrespective of the presence of physical examination data, though no significant differences were noted within each model’s performance across different data scenarios. Conclusively, while ChatGPT-4 demonstrates superior accuracy and management capabilities, the addition of physical examination data, though enhancing response detail, did not significantly surpass traditional medical resources. This underscores the utility of AI in supporting clinical decision-making, particularly in scenarios with limited data, suggesting its role as a complement to, rather than a replacement for, comprehensive clinical evaluation and expertise.
Sleep Apnea and Atrial Fibrillation: Clinical Features and Screening Diagnostic Options
Authors: Baymukanov Azamat Maratovich , Weissman Yuliya Dmitrievna , Bulavina Irina Andreevna , Ilyich Ilya Leonidovich , Termosesov Sergey Arturovich
Published: June 2024

Introduction: Obstructive sleep apnea (OSA) is associated with an increased risk of hypertension, coronary artery disease, heart failure (HF), and atrial fibrillation (AF). Materials and methods: A total of 179 patients aged 34–81 years were included in the study. The median age was 63 years (interquartile range: 56–69 years). Of these patients, 105 (58.7%) were men, and 74 (41.3%) were women; there were cases of paroxysmal (n = 99), persistent (n = 64), and permanent AF (n = 16). All patients underwent investigations including respiratory sleep monitoring, echocardiography, and 24 h Holter electrocardiography monitoring. Statistical analyses were performed using IBM SPSS Statistics 26.0. Results: OSA was detected in 131 (73.2%) patients. In patients with OSA, paroxysmal AF was commonest (n = 65), followed by persistent AF (n = 51) and permanent AF (n = 15). The patients with sleep apnea had increased body mass index (33.6 kg/m2; p = 0.02), waist circumference (114 cm; p < 0.001), and neck circumference (42 cm; p < 0.001) values. HF (OR 2.9; 95% CI: 1.4–5.9; p = 0.004) and type 2 diabetes (OR 3.6; 95% CI: 1.5–8.3; p = 0.001) were more common in patients with AF and OSA. The STOP-BANG scale (AUC = 0.706 ± 0.044; 95% CI: 0.619–0.792; p < 0.001) and the Berlin questionnaire (AUC = 0.699 ± 0.044; 95% CI: 0.614–0.785) had a higher predictive ability for identifying sleep apnea. Conclusions: Patients with AF demonstrate a high prevalence of OSA and an increased association with cardiovascular comorbidities. The STOP-BANG scale and the Berlin questionnaire can be used to screen for OSA in patients with AF.
Composing the Landscape: Analyzing Landscape Architecture as Design Formation
Authors: Moraitis Konstantinos
Published: June 2024

The article approaches ‘landscape architecture’, insisting on the term ‘architecture’ as describing landscape formations accepted as structured systems of composed, perceptual elements presenting organizational and aesthetic value. The central idea of this proposal refers to the key concept that design systems do not copy reality in its full complicated substance; they simply cannot manage to represent and work with the complex totality of the real surrounding world. They rather design abstract formational elements that ‘schematize’ reality and create composing syntactic systems, composing ‘languages’. It was in this context that modern 20th-century garden designers insisted on the comparison of landscape design approaches with architectural abstract building plans or abstract early 20th century-paintings. However, analogous correlations may also be regarded in the opposite orientation. Thus, contemporary architectural projects are often described as ‘landscape formations’ in a period of environmental sensitivity combined with enlarged topological awareness; the latter presents earth bas-relief as a convincing metaphor of topological mathematical transformations in general, associated with computational ‘animate’ design. Nevertheless, the principal aim of the article is firstly to insist on the interchangeable approaches of hard-scape architectural design and green-scape design in terms of analogous abstract and schematized formations. Moreover, the present article intends to propose a possible didactic strategy of landscape design for architects or students in schools of architecture and for attendees already accustomed to building or hard-scape urban design. This design didactic strategy is principally founded on the concept that common abstract ‘schematized’ formations underlie all those practices: landscape design as well as building and urban design.
Effect of Ultrasonic Rolling on Surface Properties of GCr15 Spherical Joint Bearing
Authors: Zhang Hao , Yang Xiuli , Ma Xiqiang , Jin Dongliang , You Jinyuan
Published: June 2024

Ultrasonic surface rolling process (USRP) has the potential to improve the surface mechanical properties of metal components with platelike or cylindrical macrostructure, but its effect on spherical surfaces remains to be studied in depth. In order to investigate the effect of USRP on the surface roughness, hardness and wear resistance of a spherical joint bearing made of GCr15 bearing steel, ultrasonic rolling strengthening was carried out on a spherical bearing surface under various conditions. The surface roughness and hardness variations of samples before and after strengthening were investigated. It was found that the USRP strengthening process can effectively enhance the surface properties of GCr15 spherical bearing materials, reduce the surface roughness by more than 45%, and increase the surface hardness by more than 10%. Friction and wear tests were carried out before and after ultrasonic rolling. The results show that the friction coefficient of the bearing surface can be reduced by 28%, and that the wear volume can be reduced by 29%. The variation in the friction coefficient correlated to the variance of wear volume as the reinforcement changes.
Post-Processing Effect on the Corrosion Resistance of Super Duplex Stainless Steel Produced by Laser Powder Bed Fusion
Authors: Brytan Zbigniew , Dagnaw Mengistu , Bidulská Jana , Bidulský Róbert , Muhamad Mohd Ridha
Published: June 2024

This study examines the microstructural characteristics and corrosion resistance of super duplex stainless steel (SDSS) produced through laser powder bed fusion (LPBF). The analysis shows that the as-printed samples mainly exhibit a ferritic microstructure, which is due to the fast-cooling rates of the LPBF technique. X-ray and microstructure analyses reveal the presence of minor austenite phases in the ferritic matrix. The process of solution annealing led to a more balanced microstructure. Analyses of corrosion resistance, such as potentiodynamic polarization tests and EIS, indicate that heat treatment has a significant impact on the corrosion behavior of SDSS. Solution annealing and stress relieving at 400 °C for 1 h can improve corrosion resistance by increasing polarization resistance and favorable EIS parameters. However, stress relieving at 550 °C for 5 h may reduce the material’s corrosion resistance due to the formation of chromium nitride. Therefore, stress relieving at 400 °C for 1 h is a practical method to significantly enhance the corrosion resistance of LPBF-printed SDSS. This method offers a balance between microstructural integrity and material performance.
A Study of the Internal Deformation Fields and the Related Microstructure Evolution during Thermal Fatigue Tests of a Single-Crystal Ni-Base Superalloy
Authors: Zong Cui , Liu Sujie , Ma Guangcai , Guo Yi , Huang Zhaohui
Published: June 2024

Ni-base superalloys operate in harsh service conditions where cyclic heating and cooling introduce deformation fields that need to be investigated in detail. We used the high-angular-resolution electron backscatter diffraction method to study the evolution of internal stress fields and dislocation density distributions in carbides, dendrites, and notch tips. The results indicate that the stress concentrations decay exponentially away from the notch, and this pattern of distribution was modified by the growth of cracks and the emission of dislocations from the crack tip. Crack initiation follows crystallographic traces and is weakly correlated with carbides and dendrites. Thermal cycles introduce local plasticity around carbides, the dendrite boundary, and cracks. The dislocations lead to higher local stored energy than the critical value that is often cited to induce recrystallization. No large-scale onset of recrystallization was detected, possibly due to the mild temperature (800 °C); however, numerous recrystallized grains were detected in carbides after 50 and 80 cycles. The results call for a detailed investigation of the microstructure-related, thermally assisted recrystallization phenomenon and may assist in the microstructure control and cooling channel design of turbine blades.
Preparation of Cellulose Fiber Loaded with CuO Nanoparticles for Enhanced Shelf Life and Quality of Tomato Fruit
Authors: Palanisamy Senthilkumar , Varnan Nandhana , Venkatachalam Shanmugam , Kuppuswamy Kumarakuru , Devi Selvaraju Gayathri , Ranjith Santhosh Kumar Devanesan Sanjeevi , Selvakesavan Rajendran Kamalabai , Bangaru Gokul , Bharathi Devaraj
Published: June 2024

The present study reports on the preparation of a cellulose fiber (CF) composite from D. lutescens, combined with copper oxide nanoparticles (DL@CF/CuO), to prolong the shelf life of tomatoes after harvest. The isolated cellulose fiber material was comprehensively characterized using XRD, FTIR, and FE-SEM analyses. The DLCF and DL@CF/CuO nanoparticles exhibited crystalline cellulose, as indicated by the XRD investigation. Both DLCF and DL@CF/CuO showed O-H and C-H FTIR spectra with identifiable vibrational peaks. The FE-SEM images depicted the dispersion of DL@CF/CuO-based fibers in a cellulose fiber matrix containing CuO nanoparticles. A 0.3% (wt/wt), a solution of DL@CF/CuO was coated onto the surface of early ripening tomato fruits. After a 25-day storage period at 25–29 °C and 85% RH, the results showed a significant extension in the shelf life of the tomato fruits, in line with changes in physiological properties and fruit quality. The extension of shelf life in tomato fruit epidermis treated with DL@CF/CuO was confirmed through FE-SEM analysis. L929 fibroblast cells were treated with the developed DL@CF/CuO nanocomposite, and no signs of toxicity were detected up to 75 µg/mL. Additionally, the DL@CF/CuO nanocomposite exhibited significant antifungal activity against Aspergillus flavus. In conclusion, this study provides novel insights for sustainable food security and waste control in the agricultural and food industries.
Understanding the Structural and Catalytic Properties of Al(IV)-2 Acidic Sites of ZSM-5
Authors: Tong Yan , Zhang Li , Ma Hong , Wang Yi , Liu Xiaolong
Published: June 2024

It is crucial to identify the structures of active sites to understand how catalysts function and to use that understanding to develop better catalytic materials. ZSM-5 zeolites with dominant Al(IV)-2 sites have been developed in this work. 1H-27Al 2D HMQC and 2D 1H TQ(DQ)-SQ NMR experiments have been performed to investigate the structural properties of this acidic site. The Al(IV)-2 sites have Brønsted and Lewis acid characteristics. The catalytic performance of Al(IV)-2 sites has been tested by n-dodecane cracking reactions. The catalytic results show that the Brønsted acidic strength of the Al(IV)-2 sites is comparable to that of the Al(IV)-1 sites, but the Al(IV)-2 sites’ Lewis acid characteristics provide extra catalytic activity. We have gained valuable insights into the characteristics of Al(IV)-2 acid sites within these materials.
Tuning Textural Properties by Changing the Morphology of SBA-15 Mesoporous Materials
Authors: Silva Francisco Emanuel da , Rigoti Eduardo , Mello Mariele Iara Soares de , Pergher Sibele B. C.
Published: June 2024

Changing the morphology is an excellent option for altering the textural parameters of SBA-15 materials. This study provides a guide on how the properties of mesoporous structures behave according to their morphology and their contribution to thermal stability. The objective of this work was to synthesize different morphologies (spherical, hexagonal prisms, rice-like grains, rods, and fibers) of SBA-15 materials and evaluate the existing textural changes. The materials were synthesized by varying the temperature of the synthesis gel from 25 °C to 55 °C, with stirring at 300 or 500 rpm. The results of X-ray diffraction, Fourier transform infrared spectroscopy, N2 adsorption and desorption, and scanning electron microscopy were evaluated. Thermal stability tests were also conducted in an inert atmosphere. The materials were successfully synthesized, and it was observed that they all exhibited different characteristics, such as their ordering, interplanar distance, mesoporous parameter, specific surface area, micropore and mesopore volumes, external mesoporous area, and wall thickness. They also presented different thermal stabilities. The rice grain morphology had the highest specific surface area (908.8 cm2/g) and the best thermal stability, while the rod morphology had the best pore diameter (7.7 nm) and microporous volume (0.078 cm3/g).
Ferroelectric Material in Triboelectric Nanogenerator
Authors: Zhang Zhiyu , Wu Tong , Sun Enqi , Chen Yahui , Wang Ning
Published: June 2024

Ferroelectric materials, with their spontaneous electric polarization, are renewing research enthusiasm for their deployment in high-performance micro/nano energy harvesting devices such as triboelectric nanogenerators (TENGs). Here, the introduction of ferroelectric materials into the triboelectric interface not only significantly enhances the energy harvesting efficiency, but also drives TENGs into the era of intelligence and integration. The primary objective of the following paper is to tackle the newest innovations in TENGs based on ferroelectric materials. For this purpose, we begin with discussing the fundamental idea and then introduce the current progress with TENGs that are built on the base of ferroelectric materials. Various strategies, such as surface engineering, either in the micro or nano scale, are discussed, along with the environmental factors. Although our focus is on the enhancement of energy harvesting efficiency and output power density by utilizing ferroelectric materials, we also highlight their incorporation in self-powered electronics and sensing systems, where we analyze the most favorable and currently accessible options in attaining device intelligence and multifunctionality. Finally, we present a detailed outlook on TENGs that are based on ferroelectric materials.
Differentiation of Solutions of Caputo Boundary Value Problems with Respect to Boundary Data
Authors: Lyons Jeffrey W.
Published: June 2024

Under suitable continuity and uniqueness conditions, solutions of an α order Caputo fractional boundary value problem are differentiated with respect to boundary values and boundary points. This extends well-known results for nth order boundary value problems. The approach used applies a standard algorithm to achieve the result and makes heavy use of recent results for differentiation of solutions of Caputo fractional intial value problems with respect to initial conditions and continuous dependence for Caputo fractional boundary value problems.
Covers of Finitely Generated Acts over Monoids
Authors: Zhang Xiaoqin , Zhao Tingting
Published: June 2024

This paper attempts to initiate the study of covers of finitely generated S-acts over monoids. We provide necessary and sufficient conditions for a monoid to ensure that n-generated S-acts have strongly flat covers, Condition (P) covers, and projective covers. The main conclusions extend some known results. We also show that Condition (P) covers of finitely generated S-acts are not unique, unlike strongly flat covers. Additionally, we demonstrate the property of Enochs’ X-precover of S-act A, where X denotes a class of S-acts that are closed under isomorphisms.
Classical 1-Absorbing Primary Submodules
Authors: Yılmaz Uçar Zeynep , Ersoy Bayram Ali , Tekir Ünsal , Yetkin Çelikel Ece , Onar Serkan
Published: June 2024

Over the years, prime submodules and their generalizations have played a pivotal role in commutative algebra, garnering considerable attention from numerous researchers and scholars in the field. This papers presents a generalization of 1-absorbing primary ideals, namely the classical 1-absorbing primary submodules. Let ℜ be a commutative ring and M an ℜ-module. A proper submodule K of M is called a classical 1-absorbing primary submodule of M, if xyzη∈K for some η∈M and nonunits x,y,z∈ℜ, then xyη∈K or ztη∈K for some t≥1. In addition to providing various characterizations of classical 1-absorbing primary submodules, we examine relationships between classical 1-absorbing primary submodules and 1-absorbing primary submodules. We also explore the properties of classical 1-absorbing primary submodules under homomorphism in factor modules, the localization modules and Cartesian product of modules. Finally, we investigate this class of submodules in amalgamated duplication of modules.
The Ribbon Elements of the Quantum Double of Generalized Taft–Hopf Algebra
Authors: Sun Hua , Zhang Yuyan , Jiang Ziliang , Huang Mingyu , Hu Jiawei
Published: June 2024

Let s, t be two positive integers and k be an algebraically closed field with char (k)∤st. We show that the Drinfeld double D(⋀st,t*cop) of generalized Taft–Hopf algebra ⋀st,t*cop has ribbon elements if and only if t is odd. Moreover, if s is even and t is odd, then D(⋀st,t*cop) has two ribbon elements, and if both s and t are odd, then D(⋀st,t*cop) has only one ribbon element. Finally, we compute explicitly all ribbon elements of D(⋀st,t*cop).
Neurological Examination via Telemedicine: An Updated Review Focusing on Movement Disorders
Authors: Angelopoulou Efthalia , Koros Christos , Stanitsa Evangelia , Stamelos Ioannis , Kontaxopoulou Dionysia , Fragkiadaki Stella , Papatriantafyllou John D. , Smaragdaki Evangelia , Vourou Kalliopi , Pavlou Dimosthenis , Bamidis Panagiotis D. , Stefanis Leonidas , Papageorgiou Sokratis G.
Published: June 2024

Patients with movement disorders such as Parkinson’s disease (PD) living in remote and underserved areas often have limited access to specialized healthcare, while the feasibility and reliability of the video-based examination remains unclear. The aim of this narrative review is to examine which parts of remote neurological assessment are feasible and reliable in movement disorders. Clinical studies have demonstrated that most parts of the video-based neurological examination are feasible, even in the absence of a third party, including stance and gait—if an assistive device is not required—bradykinesia, tremor, dystonia, some ocular mobility parts, coordination, and gross muscle power and sensation assessment. Technical issues (video quality, internet connection, camera placement) might affect bradykinesia and tremor evaluation, especially in mild cases, possibly due to their rhythmic nature. Rigidity, postural instability and deep tendon reflexes cannot be remotely performed unless a trained healthcare professional is present. A modified version of incomplete Unified Parkinson’s Disease Rating Scale (UPDRS)-III and a related equation lacking rigidity and pull testing items can reliably predict total UPDRS-III. UPDRS-II, -IV, Timed “Up and Go”, and non-motor and quality of life scales can be administered remotely, while the remote Movement Disorder Society (MDS)-UPDRS-III requires further investigation. In conclusion, most parts of neurological examination can be performed virtually in PD, except for rigidity and postural instability, while technical issues might affect the assessment of mild bradykinesia and tremor. The combined use of wearable devices may at least partially compensate for these challenges in the future.
The Influence of Cr Addition on the Microstructure and Mechanical Properties of Fe-25Mn-10Al-1.2C Lightweight Steel
Authors: Bai Rui , Du Yunfei , He Xiuli , Zhang Yaqin
Published: June 2024

The influence of Cr addition on the microstructure and tensile properties of Fe-25Mn-10Al-1.2C lightweight steel was investigated. The characteristics of the microstructures and deformation behavior were carried out through X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), electron backscatter diffraction (EBSD), and room temperature tensile testing. Fe-20Mn-12Al-1.5C steel without Cr exhibited a fully austenitic single phase. With the addition of Cr, the volume fraction of ferrite continuously increased. When the content of Cr exceeded 5 wt%, the precipitation of Cr7C3 carbides was observed. In the steel with 5 wt% Cr, the quantity of κ carbides remarkably decreased, indicating that the addition of 5 wt% Cr significantly inhibited the nucleation of κ-carbides. As the Cr content increases from 0 wt% to 5 wt%, the austenite grain sizes were 8.8 μm and 2.5 μm, respectively, demonstrating that Cr alloying is an effective method of grain refinement. Tensile strength increased slightly while elongation decreased with increasing Cr content. As the Cr content exceeded 5 wt%, the yield strength increased but the elongation drastically decreased. The steel with 2.5 wt% Cr achieved a synergistic improvement in strength and ductility, exhibiting the best tensile performance.
Material and Microstructure Analysis of Wood Color Paintings from Shaanxi Cangjie Temple, China
Authors: Huang Dan , Han Kezhu , Teri Gele , Cheng Cong , Qi Yunpeng , Li Yuhu
Published: June 2024

Cangjie Temple was built to commemorate Cangjie, the legendary inventor of Chinese characters. It stands as one of the few remaining temples in China dedicated to the invention and creation of writing. In this study, the material properties of wooden paintings from the Cangjie temple were characterized using Polarized Light Microscopy (PLM), Scanning Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy (SEM-EDS), Micro-confocal Raman Spectroscopy, X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Pyrolysis-Gas Chromatography-Mass Spectrometry (Py-GC/MS). It was confirmed that the pigments of the paintings included cinnabar, lapis lazuli, lead white, Paris green, and carbon black. The proteinaceous glue was used as an adhesive in the pigment samples, with tung oil likely being utilized as a primer for the wooden structures before painting. This study not only provides valuable data support for the conservation and restoration of the architectural features of Cangjie Temple but also provides useful reference for the maintenance and inheritance of similar ancient buildings.
Mitochondrial Dysfunction, Its Oxidative Stress-Induced Pathologies and Redox Bioregulation through Low-Dose Medical Ozone: A Systematic Review
Authors: Viebahn-Haensler Renate , León Fernández Olga Sonia
Published: June 2024

Our hypothesis that controlled ozone applications interfere with the redox balance of a biological organism (first published in 1998 with a preclinical trial on protecting the liver from CCl4 intoxication) has been verified over the past two decades in reactive oxygen species (ROS)-induced mitochondrial pathologies, such as rheumatoid arthritis, osteoarthritis, aging processes and type 2 diabetes, and in the prevention of intoxications. Low-dose ozone acts as a redox bioregulator: the restoration of the disturbed redox balance is comprehensible in a number of preclinical and clinical studies by a remarkable increase in the antioxidant repair markers, here mainly shown as a glutathione increase and a reduction in oxidative stress markers, mainly malondialdehyde. The mechanism of action is shown, and relevant data are displayed, evaluated and comprehensively discussed: the repair side of the equilibrium increases by 21% up to 140% compared to the non-ozone-treated groups and depending on the indication, the stress markers are simultaneously reduced, and the redox system regains its balance.
Health-Related Composition and Bioactivity of an Agave Sap/Prickly Pear Juice Beverage
Authors: Duque-Buitrago Luisa Fernanda , Solórzano-Lugo Iraham Enrique , González-Vázquez Marcela , Jiménez-Martínez Cristian , Hernández-Aguirre María Antonia , Osorio-Díaz Perla , Calderón-Domínguez Georgina , Loera-Castañeda Verónica , Mora-Escobedo Rosalva
Published: June 2024

In this study, a beverage made from a combination of Agave sap (AS) and prickly pear juice (PPJ) was analyzed for its nutrients and bioactive and potentially health-promoting compounds. The beverage was evaluated for its ability to act as an antioxidant, regulate glycemic properties, and undergo gut bacterial fermentation in vitro. The major mono- and oligosaccharides present in the beverage were galacturonic acid (217.74 ± 13.46 mg/100 mL), rhamnose (227.00 ± 1.58 mg/100 mL), and fructose (158.16 ± 8.86 mg/mL). The main phenolic compounds identified were protocatechuic acid (440.31 ± 3.06 mg/100 mL) and catechin (359.72 ± 7.56 mg/100 mL). It was observed that the beverage had a low glycemic index (<40) and could inhibit digestive carbohydrases. The combination of ingredients also helped to reduce gas production during AS fermentation from 56.77 cm3 to 15.67 cm3. The major SCFAs produced during fermentation were butyrate, acetate, and propionate, with valerate being produced only during the late fermentation of the AS. This beverage is rich in bioactive compounds, such as polyphenols and dietary fiber, which will bring health benefits when consumed.
Dynamic Interplay between Microbiota Shifts and Differential Metabolites during Dairy Processing and Storage
Authors: Zhang Yinan , Yu Peng , Tao Fei
Published: June 2024

Due to the intricate complexity of the original microbiota, residual heat-resistant enzymes, and chemical components, identifying the essential factors that affect dairy quality using traditional methods is challenging. In this study, raw milk, pasteurized milk, and ultra-heat-treated (UHT) milk samples were collectively analyzed using metagenomic next-generation sequencing (mNGS), high-throughput liquid chromatography-mass spectrometry (LC-MS), and gas chromatography–mass spectrometry (GC-MS). The results revealed that raw milk and its corresponding heated dairy products exhibited different trends in terms of microbiota shifts and metabolite changes during storage. Via the analysis of differences in microbiota and correlation analysis of the microorganisms present in differential metabolites in refrigerated pasteurized milk, the top three differential microorganisms with increased abundance, Microbacterium (p < 0.01), unclassified Actinomycetia class (p < 0.05), and Micrococcus (p < 0.01), were detected; these were highly correlated with certain metabolites in pasteurized milk (r > 0.8). This indicated that these genera were the main proliferating microorganisms and were the primary genera involved in the metabolism of pasteurized milk during refrigeration-based storage. Microorganisms with decreased abundance were classified into two categories based on correlation analysis with certain metabolites. It was speculated that the heat-resistant enzyme system of a group of microorganisms with high correlation (r > 0.8), such as Pseudomonas and Acinetobacter, was the main factor causing milk spoilage and that the group with lower correlation (r < 0.3) had a lower impact on the storage process of pasteurized dairy products. By comparing the metabolic pathway results based on metagenomic and metabolite annotation, it was proposed that protein degradation may be associated with microbial growth, whereas lipid degradation may be linked to raw milk’s initial heat-resistant enzymes. By leveraging the synergy of metagenomics and metabolomics, the interacting factors determining the quality evolution of dairy products were systematically investigated, providing a novel perspective for controlling dairy processing and storage effectively.
Efficient Preparation of Biodiesel Using Sulfonated Camellia oleifera Shell Biochar as a Catalyst
Authors: Yang Zhimin , Wang Yu , Wu Xichang , Quan Wenxuan , Chen Qi , Wang Anping
Published: June 2024

This study prepared sulfonated Camellia oleifera shell biochar using Camellia oleifera shell agricultural waste as a carbon source, and evaluated its performance as a catalyst for preparing biodiesel. The biochar obtained from carbonizing Camellia oleifera shells at 500 °C for 2 h serves as the carbon skeleton, and then the biochar is sulfonated with chlorosulfonic acid. The sulfonic acid groups are mainly grafted onto the surface of Camellia oleifera shell biochar through covalent bonding to obtain sulfonic acid type biochar catalysts. The catalysts were characterized by Scanning Electron Microscope (SEM), X-ray diffraction (XRD), Nitrogen adsorption-desorption Brunel-Emmett-Taylor Theory (BET), and Fourier-transform infrared spectroscopy (FT-IR). The acid density of the sulfonated Camellia oleifera fruit shell biochar catalyst is 2.86 mmol/g, and the specific surface area is 2.67 m2/g, indicating high catalytic activity. The optimal reaction conditions are 4 wt% catalyst with a 6:1 alcohol to oil ratio. After esterification at 70 °C for 2 h, the yield of biodiesel was 91.4%. Under the optimal reaction conditions, after four repeated uses of the catalyst, the yield of biodiesel still reached 90%. Therefore, sulfonated Camellia oleifera shell biochar is a low-cost, green, non-homogeneous catalyst with great potential for biodiesel production by esterification reaction in future development.
A Benzothiadiazole-Based Zn(II) Metal–Organic Framework with Visual Turn-On Sensing for Anthrax Biomarker and Theoretical Calculation
Authors: Ru Jing , Shi Yi-Xuan , Yang Qing-Yun , Li Teng , Wang Hai-Ying , Cao Fan , Guo Qiang , Wang Yan-Lan
Published: June 2024

2,6-pyridine dicarboxylic acid (DPA) is an exceptional biomarker of notorious anthrax spores. Therefore, the rapid, sensitive, and selective quantitative detection of DPA is extremely significant and urgent. This paper reports a Zn(II) metal–organic framework with the formula of {[Zn6(NDA)6(DPBT)3] 2H2O·3DMF}n (MOF-1), which consists of 2,6-naphthalenedicarboxylic acid (2,6-NDA), 4,7-di(4-pyridyl)-2,1,3-benzothiadiazole (DPBT), and Zn(II) ions. Structural analysis indicated that MOF-1 is a three-dimensional (3D) network which crystallized in the monoclinic system with the C2/c space group, revealing high pH, solvent, and thermal stability. Luminescence sensing studies demonstrated that MOF-1 had the potential to be a highly selective, sensitive, and recyclable fluorescence sensor for the identification of DPA. Furthermore, fluorescent test paper was made to detect DPA promptly with color changes. The enhancement mechanism was established by the hydrogen-bonding interaction and photoinduced electron transfer transition between MOF-1 and DPA molecules.
Preparative Fractionation of Brazilian Red Propolis Extract Using Step-Gradient Counter-Current Chromatography
Authors: Lopez Begoña Gimenez-Cassina , Marcucci Maria Cristina , Rocco Silvana Aparecida , Sforça Maurício Luís , Eberlin Marcos Nogueira , Hewitson Peter , Ignatova Svetlana , Sawaya Alexandra Christine Helena Frankland
Published: June 2024

Propolis is a resinous bee product with a very complex composition, which is dependent upon the plant sources that bees visit. Due to the promising antimicrobial activities of red Brazilian propolis, it is paramount to identify the compounds responsible for it, which, in most of the cases, are not commercially available. The aim of this study was to develop a quick and clean preparative-scale methodology for preparing fractions of red propolis directly from a complex crude ethanol extract by combining the extractive capacity of counter-current chromatography (CCC) with preparative HPLC. The CCC method development included step gradient elution for the removal of waxes (which can bind to and block HPLC columns), sample injection in a single solvent to improve stationary phase stability, and a change in the mobile phase flow pattern, resulting in the loading of 2.5 g of the Brazilian red propolis crude extract on a 912.5 mL Midi CCC column. Three compounds were subsequently isolated from the concentrated fractions by preparative HPLC and identified by NMR and high-resolution MS: red pigment, retusapurpurin A; the isoflavan 3(R)-7-O-methylvestitol; and the prenylated benzophenone isomers xanthochymol/isoxanthochymol. These compounds are markers of red propolis that contribute to its therapeutic properties, and the amount isolated allows for further biological activities testing and for their use as chromatographic standards.
Structural Design, Anticancer Evaluation, and Molecular Docking of Newly Synthesized Ni(II) Complexes with ONS-Donor Dithiocarbazate Ligands
Authors: Gatto Claudia C. , Cavalcante Cássia de Q. O. , Lima Francielle C. , Nascimento Érica C. M. , Martins João B. L. , Santana Brunna L. O. , Gualberto Ana C. M. , Pittella-Silva Fabio
Published: June 2024

The current article reports the investigation of three new Ni(II) complexes with ONS-donor dithiocarbazate ligands: [Ni(L1)PPh3] (1), [Ni(L2)PPh3] (2), and [Ni(L2)Py] (3). Single-crystal X-ray analyses revealed mononuclear complexes with a distorted square planar geometry and the metal centers coordinated with a doubly deprotonated dithiocarbazate ligand and coligand pyridine or triphenylphosphine. The non-covalent interactions were investigated by the Hirshfeld surface and the results revealed that the strongest interactions were π⋅⋅⋅π stacking interactions and non-classical hydrogen bonds C–H···H and C–H···N. Physicochemical and spectroscopic methods indicate the same structures in the solid state and solution. The toxicity effects of the free ligands and Ni(II) complexes were tested on the human breast cancer cell line MCF-7 and non-malignant breast epithelial cell line MCF-10A. The half-maximal inhibitory concentration (IC50) values, indicating that the compounds were potent in inhibiting cell growth, were obtained for both cell lines at three distinct time points. While inhibitory effects were evident in both malignant and non-malignant cells, all three complexes demonstrated lower IC50 values for malignant breast cell lines than their non-malignant counterparts, suggesting a stronger impact on cancerous cell lines. Furthermore, molecular docking studies were performed showing the complex (2) as a promising candidate for further therapeutic exploration.
Multi-Endpoint Toxicological Assessment of Chrysin Loaded Oil-in-Water Emulsion System in Different Biological Models
Authors: Pitchakarn Pornsiri , Ting Pisamai , Buacheen Pensiri , Karinchai Jirarat , Inthachat Woorawee , Chantong Boonrat , Suttisansanee Uthaiwan , Nuchuchua Onanong , Temviriyanukul Piya
Published: June 2024

Chrysin is hypothesized to possess the ability to prevent different illnesses, such as diabetes, cancer, and neurodegenerative disorders. Nonetheless, chrysin has a low solubility under physiological conditions, resulting in limited bioavailability. In a previous study, we utilized an oil-in-water emulsion system (chrysin-ES or chrysin-NE) to encapsulate chrysin, thereby increasing its bioaccessibility and preserving its antioxidant and anti-Alzheimer’s properties. To promote the chrysin-ES as a supplementary and functional food, it was obligatory to carry out a safety assessment. Cytotoxicity testing showed that chrysin-ES was harmless, with no killing effect on 3T3-L1 (adipocytes), RAW 264.7 (macrophages), HEK293 (kidney cells), and LX-2 (hepatic stellate cells). The acute toxicity evaluation demonstrated that the 50% lethal dose (LD50) for chrysin-ES was greater than 2000 mg/kg BW. Genotoxicity assessments found that chrysin-ES did not induce DNA mutations in vitro or in vivo. Furthermore, chrysin and chrysin-ES exhibited anti-mutagenic properties against PhIP-induced and IQ-induced mutagenesis in the Ames test, while they inhibited urethane-, ethyl methanesulfonate-, mitomycin C-, and N-nitrosomethylurea-mediated mutations in Drosophila. The present study illustrates the safety and anti-genotoxicity properties of chrysin-ES, allowing for the further development of chrysin-based food supplements and nutraceuticals.