bluuebunny/crossref_metadata_2025 huggingface dataset:
Periodontal probing on digital images compared to clinical measurements in periodontitis patients
Authors: Chung Hye-Min , Park Jin-Young , Ko Kyung-A. , Kim Chang-Sung , Choi Seong-Ho , Lee Jung-Seok
Published: January 2022

The aim of the study was to compare the supra-alveolar gingival dimension (GD) and the clinical pocket probing depth (PD) by combining data from an intraoral scanner (IOS) and cone-beam computed tomography (CBCT) and identify the clinical features affecting the clinical PD. 1,071 sites from 11 patients were selected for whom CBCT, IOS images, and periodontal charts were recorded at the same visit. CBCT and IOS data were superimposed. GD was measured on cross-sectional images of the probed sites. The level of agreement and correlation between GD and PD were assessed for the entire population and within groups (treated vs untreated, bleeding on probing [BOP] vs no BOP, and PDs of 0–3 mm vs 4–5 mm vs ≥ 6 mm). The mean [± SD] difference between GD and PD was 0.82 [± 0.69] mm, and they were positively correlated (r = 0.790, p < 0.001). The correlations between GD and PD were stronger for untreated sites, sites with BOP, and sites with a larger PD. Within the limitations of this study, the similarity between GD and PD may suggest a possible tendency of overestimation when recording PD.
Influence of state reopening policies in COVID-19 mortality
Authors: Tam Ka-Ming , Walker Nicholas , Moreno Juana
Published: January 2022

By the end of May 2020, all states in the US have eased their COVID-19 mitigation measures. Different states adopted markedly different policies and timing for reopening. An important question remains in how the relaxation of mitigation measures is related to the number of casualties. To address this question, we compare the actual data to a hypothetical case in which the mitigation measures are left intact using a projection of the data from before mitigation measures were eased. We find that different states have shown significant differences between the actual number of deaths and the projected figures within the present model. We relate these differences to the states different policies and reopening schedules. Our study provides a gauge for the effectiveness of the approaches by different state governments and can serve as a guide for implementing best policies in the future. According to the Pearson correlation coefficients we obtained, the face mask mandate has the strongest correlation with the death count than any other policies we considered.
Mapping native and non-native vegetation in the Brazilian Cerrado using freely available satellite products
Authors: Lewis Kennedy , de V. Barros Fernanda , Cure Marcio B. , Davies Christian A. , Furtado Mariana N. , Hill Timothy C. , Hirota Marina , Martins Demétrius L. , Mazzochini Guilherme G. , Mitchard Edward T. A. , Munhoz Cássia B. R. , Oliveira Rafael S. , Sampaio Alexandre B. , Saraiva Nicholas A. , Schmidt Isabel B. , Rowland Lucy
Published: January 2022

Native vegetation across the Brazilian Cerrado is highly heterogeneous and biodiverse and provides important ecosystem services, including carbon and water balance regulation, however, land-use changes have been extensive. Conservation and restoration of native vegetation is essential and could be facilitated by detailed landcover maps. Here, across a large case study region in Goiás State, Brazil (1.1 Mha), we produced physiognomy level maps of native vegetation (n = 8) and other landcover types (n = 5). Seven different classification schemes using different combinations of input satellite imagery were used, with a Random Forest classifier and 2-stage approach implemented within Google Earth Engine. Overall classification accuracies ranged from 88.6–92.6% for native and non-native vegetation at the formation level (stage-1), and 70.7–77.9% for native vegetation at the physiognomy level (stage-2), across the seven different classifications schemes. The differences in classification accuracy resulting from varying the input imagery combination and quality control procedures used were small. However, a combination of seasonal Sentinel-1 (C-band synthetic aperture radar) and Sentinel-2 (surface reflectance) imagery resulted in the most accurate classification at a spatial resolution of 20 m. Classification accuracies when using Landsat-8 imagery were marginally lower, but still reasonable. Quality control procedures that account for vegetation burning when selecting vegetation reference data may also improve classification accuracy for some native vegetation types. Detailed landcover maps, produced using freely available satellite imagery and upscalable techniques, will be important tools for understanding vegetation functioning at the landscape scale and for implementing restoration projects.
Mechanical frequency control in inductively coupled electromechanical systems
Authors: Luschmann Thomas , Schmidt Philip , Deppe Frank , Marx Achim , Sanchez Alvaro , Gross Rudolf , Huebl Hans
Published: January 2022

Nano-electromechanical systems implement the opto-mechanical interaction combining electromagnetic circuits and mechanical elements. We investigate an inductively coupled nano-electromechanical system, where a superconducting quantum interference device (SQUID) realizes the coupling. We show that the resonance frequency of the mechanically compliant string embedded into the SQUID loop can be controlled in two different ways: (1) the bias magnetic flux applied perpendicular to the SQUID loop, (2) the magnitude of the in-plane bias magnetic field contributing to the nano-electromechanical coupling. These findings are quantitatively explained by the inductive interaction contributing to the effective spring constant of the mechanical resonator. In addition, we observe a residual field dependent shift of the mechanical resonance frequency, which we attribute to the finite flux pinning of vortices trapped in the magnetic field biased nanostring.
Comparison of retinal layer thickness and microvasculature changes in patients with diabetic retinopathy treated with intravitreous bevacizumab vs panretinal photocoagulation
Authors: Lee Min-Woo , Baek Seung-Kook , Lee Kook-Hyung , Lee Sung-Chul , Kim Jung-Yeul , Lee Young-Hoon
Published: January 2022

To compare changes in retinal layers and microvasculature in diabetic retinopathy (DR) patients after bevacizumab therapy and panretinal photocoagulation (PRP). This prospective study divided patients into two groups: patients treated with bevacizumab and those treated with PRP. Patients visited our retinal clinic at 1, 3, and 6 months after treatment. Retinal layer thickness and vessel density (VD) using optical coherence tomography angiography were analyzed. 37 eyes in the bevacizumab group and 36 eyes in the PRP group were enrolled. In the bevacizumab group, the parafoveal RNFL, GCL, and IPL thicknesses significantly decreased (P < 0.001, P = 0.013, and P = 0.017, respectively), whereas the thicknesses in the PRP group showed an increasing tendency over time (P = 0.087, P = 0.005, and P = 0.003, respectively). The VD of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in the bevacizumab group did not show significant changes, whereas the VD in the PRP group significantly increased over time (both P < 0.001). Additionally, RNFL (P = 0.001) and GCL thicknesses (P = 0.035) were significant factors affecting changes in BCVA, whereas the VDs of SCP and DCP did not. Patients who received bevacizumab therapy did not show a significant change in macular VD, whereas the VD of patients after PRP significantly increased after treatment. The increased macular VD in patients after PRP would be associated with the increased inner retinal layer thickness after treatment, which was significantly related to the impairment in visual acuity.
Competition between the tadpoles of Japanese toads versus frogs
Authors: Haramura Takashi , Eto Koshiro , Crossland Michael R. , Nishikawa Kanto , Shine Richard
Published: January 2022

Competition within and among species can play a key role in structuring the assemblages of anuran tadpoles. Previous studies have reported that tadpoles of the invasive cane toad (Rhinella marina) are more strongly disadvantaged by the presence of native frog tadpoles than by the same number of conspecific toad tadpoles. That effect might arise from a lack of coevolution of the invasive toad with its competitors; and/or from a generalized superiority of frog tadpoles over toad tadpoles. To clarify those possibilities, we conducted experimental trials using the larvae of a native rather than invasive toad (Bufo japonicus formosusin Japan) exposed to larvae of native anurans (the sympatric frogsRana japonicaandRana ornativentrisand the parapatric toadBufo japonicus japonicus). In intraspecific competition trials, higher densities ofB. j. formosusprolonged the larval period and reduced size at metamorphosis, but did not affect survival. In interspecific competition trials, the effects of the other anuran species onB. j. formosuswere similar to the effects of the same number of conspecific larvae. This similarity in impact of interspecificversusintraspecific competition argues against any overall competitive superiority of frog larvae over toad larvae. Instead, the vulnerability of larval cane toads to frog tadpoles may result from a lack of coevolutionary history.
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection
Authors: Sanchez-Burgos Laura , Gómez-López Gonzalo , Al-Shahrour Fátima , Fernandez-Capetillo Oscar
Published: January 2022

The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory “cytokine storm” (CS) plays a determinant role. Here, we used transcriptomic data from the bronchoalveolar lavage fluid (BALF) of COVID-19 patients undergoing a CS to obtain gene-signatures associated to this pathology. Using these signatures, we interrogated the Connectivity Map (CMap) dataset that contains the effects of over 5000 small molecules on the transcriptome of human cell lines, and looked for molecules which effects on transcription mimic or oppose those of the CS. As expected, molecules that potentiate immune responses such as PKC activators are predicted to worsen the CS. In addition, we identified the negative regulation of female hormones among pathways potentially aggravating the CS, which helps to understand the gender-related differences in COVID-19 mortality. Regarding drugs potentially counteracting the CS, we identified glucocorticoids as a top hit, which validates our approach as this is the primary treatment for this pathology. Interestingly, our analysis also reveals a potential effect of MEK inhibitors in reverting the COVID-19 CS, which is supported by in vitro data that confirms the anti-inflammatory properties of these compounds.
Temporomandibular disorders cases with high-impact pain are more likely to experience short-term pain fluctuations
Authors: Herrero Babiloni Alberto , Exposto Fernando G. , Peck Connor M. , Lindgren Bruce R. , Martel Marc O. , Lenglet Christophe , Bereiter David A. , Eberly Lynn E. , Moana-Filho Estephan J.
Published: January 2022

Temporomandibular disorders (TMD) patients can present clinically significant jaw pain fluctuations which can be debilitating and lead to poor global health. The Graded Chronic Pain Scale evaluates pain-related disability and its dichotomous grading (high/low impact pain) can determine patient care pathways and in general high-impact pain patients have worse treatment outcomes. Individuals with low-impact TMD pain are thought to have better psychosocial functioning, more favorable disease course, and better ability to control pain, while individuals with high-impact pain can present with higher levels of physical and psychological symptoms. Thereby, there is reason to believe that individuals with low- and high-impact TMD pain could experience different pain trajectories over time. Our primary objective was to determine if short-term jaw pain fluctuations serve as a clinical marker for the impact status of TMD pain. To this end, we estimated the association between high/low impact pain status and jaw pain fluctuations over three visits (≤ 21-day-period) in 30 TMD cases. Secondarily, we measured the association between jaw pain intensity and pressure pain thresholds (PPT) over the face and hand, the latter measurements compared to matched pain-free controls (n = 17). Jaw pain fluctuations were more frequent among high-impact pain cases (n = 15) than low-impact pain cases (n = 15) (OR 5.5; 95% CI 1.2, 26.4; p value = 0.033). Jaw pain ratings were not associated with PPT ratings (p value > 0.220), suggesting different mechanisms for clinical versus experimental pain. Results from this proof-of-concept study suggest that targeted treatments to reduce short-term pain fluctuations in high-impact TMD pain is a potential strategy to achieve improved patient perception of clinical pain management outcomes.
Effects of reduced salinity caused by reclamation on population and physiological characteristics of the sesarmid crab Chiromantes dehaani
Authors: Lv Weiwei , Yuan Quan , Huang Weiwei , Sun Xiaolin , Zhou Wenzong , Zhao Yunlong
Published: January 2022

Reduced salinity is a major factor that causes macrobenthic degradation in reclaimed wetlands. We investigated populations of the sesarmid crab Chiromantes dehaani in reclaimed and natural wetlands. Then, in the laboratory, we exposed male and female crabs to four salinity levels (0, 6, 12 and 18) for 96 h to analyse the effects of reduced salinity on osmoregulatory enzyme activities in the posterior gills and digestive and immune enzyme activities in the hepatopancreas of C. dehaani. The results revealed a significant positive correlation between the number of crabs and salinity. In the laboratory, we found that the isosmotic point of C. dehaani was close to 16 ppt. The crabs showed strong hyper-osmotic regulation when exposed to 0–6 ppt salinities. Moreover, in this salinity range, amylase activities were significantly inhibited. Under low-salinity stress, the immune enzyme activities were significantly activated. However, phenoloxidase and lysozyme activities were inhibited in the freshwater environment. The male and female crabs showed no significant differences in most of the enzyme activities. Thus, reduced salinity can adversely affect the digestive and immune functions of C. dehaani, which may cause population degradation in reclaimed wetlands. Our findings can provide new insights into the effects of reclamation on macrobenthos.
Identification of a clonal population of Aspergillus flavus by MALDI-TOF mass spectrometry using deep learning
Authors: Normand Anne-Cécile , Chaline Aurélien , Mohammad Noshine , Godmer Alexandre , Acherar Aniss , Huguenin Antoine , Ranque Stéphane , Tannier Xavier , Piarroux Renaud
Published: January 2022

The spread of fungal clones is hard to detect in the daily routines in clinical laboratories, and there is a need for new tools that can facilitate clone detection within a set of strains. Currently, Matrix Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry is extensively used to identify microbial isolates at the species level. Since most of clinical laboratories are equipped with this technology, there is a question of whether this equipment can sort a particular clone from a population of various isolates of the same species. We performed an experiment in which 19 clonal isolates of Aspergillus flavus initially collected on contaminated surgical masks were included in a set of 55 A. flavus isolates of various origins. A simple convolutional neural network (CNN) was trained to detect the isolates belonging to the clone. In this experiment, the training and testing sets were totally independent, and different MALDI-TOF devices (Microflex) were used for the training and testing phases. The CNN was used to correctly sort a large portion of the isolates, with excellent (> 93%) accuracy for two of the three devices used and with less accuracy for the third device (69%), which was older and needed to have the laser replaced.
Chronic inflammation markers and cytokine-specific autoantibodies in Danish blood donors with restless legs syndrome
Authors: Dowsett Joseph , Didriksen Maria , von Stemann Jakob Hjorth , Larsen Margit Hørup , Thørner Lise Wegner , Sørensen Erik , Erikstrup Christian , Pedersen Ole Birger , Hansen Morten Bagge , Eugen-Olsen Jesper , Banasik Karina , Ostrowski Sisse Rye
Published: January 2022

Restless Legs Syndrome (RLS) is a neurological sensorimotor disorder negatively impacting sufferers’ quality of sleep and health-related quality of life. The pathophysiology of RLS is poorly understood and research focusing on the link between RLS and inflammation has been limited. Our study aimed to investigate whether chronic inflammation markers C-reactive protein (CRP) and soluble urokinase-type plasminogen activator receptor (suPAR), as well plasma levels of five different cytokine-specific autoantibodies (c-aAb), i.e. modulators of inflammation, associate with RLS in otherwise healthy individuals. CRP, suPAR and c-aAb were measured in plasma samples of participants from the Danish Blood Donor Study in 2010. Returning donors between 2015 and 2018 completed the validated Cambridge-Hopkins RLS-questionnaire for RLS assessment, resulting in datasets with RLS assessment and values for CRP (N = 3564), suPAR (N = 2546) and c-aAb (N = 1478). We performed logistic regression models using the CRP, suPAR or c-aAb as the independent variable and RLS status as the dependent variable, adjusted for appropriate covariates. Our study indicates that a high concentration of CRP is associated with RLS, while an increased probability of experiencing frequent RLS symptoms in those with an elevated plasma suPAR level appears to be mediated through lifestyle factors. We additionally report that a high titer of autoantibodies specific against the cytokine interferon-alpha was associated with RLS. Our results support the existence of links between systemic inflammation and RLS, though further RLS studies on CRP, suPAR and c-aAb in larger cohorts are warranted to confirm our findings and further reveal the hitherto underexplored links between RLS and inflammation.
Psychological impact of far-right terrorism against Muslim minorities on national distress, community, and wellbeing
Authors: Byrne Kate G. , Yogeeswaran Kumar , Dorahy Martin J. , Gale Jessica , Afzali M. Usman , Bulbulia Joseph , Sibley Chris G.
Published: January 2022

The Christchurch mosque shootings on March 15th, 2019 was the deadliest incident of mass violence in New Zealand for over a century. The present study investigated the psychological impact of these terrorist attacks targeting a specific minority community on the psychological functioning of the wider New Zealand population by examining changes in terrorism anxiety, sense of community, psychological distress, and wellbeing. Data from the New Zealand Attitudes and Values Survey (N = 47,951; age range 18–99 years, M = 48.59, SD = 13.86; 62% female) collected across a year, including approximately 6 months following the terrorist attack, was used. Regression discontinuity analyses found a statistically significant increase in terrorism anxiety and sense of community following the attacks, yet counterintuitively, no significant change in psychological distress or wellbeing. These findings provide unique insight into the psychological implications of politically motivated violence for the wider population when terrorism is directed toward a specific minority group.
Late-life longitudinal blood pressure trajectories as predictor of dementia
Authors: Lee Allen T. C. , Fung Ada W. T. , Richards Marcus , Chan Wai C. , Chiu Helen F. K. , Lee Ruby S. Y. , Lam Linda C. W.
Published: January 2022

While hypertension is widely recognized as a risk factor for dementia, few observational studies and clinical trials fully accounted for the effect of age on blood pressure (BP) changes prior to dementia onset. In this territory-wide population-based longitudinal study of 16,591 community-living dementia-free older adults, we followed their BP and cognitive status and tested if loss of longitudinal increase in BP in late life was associated with higher dementia risk in 6 years, with consideration of the confounding effects of hypertension, hypotension, BP variability, and other health problems and behaviours and, in the data analysis, exclusion of individuals who developed dementia within 3 years after baseline to minimize risk of reverse causality. Over 72,997 person-years of follow-up, 1429 participants developed dementia. We found that loss of longitudinal increase in systolic BP (defined as SBP increased by either < 10 mmHg or 10%) from baseline to Year 3 was independently associated with higher risk of incident dementia at Years 4 to 6 (adjusted OR 1.22, 95% CI 1.02–1.45, p = 0.03; adjusted OR 1.24, 95% CI 1.03–1.50, p = 0.02; respectively). Our findings suggest that late-life SBP trajectory changes might independently predict dementia onset and highlight the importance of including longitudinal BP monitoring in dementia risk assessment.
PSD3 downregulation confers protection against fatty liver disease
Authors: Mancina Rosellina M. , Sasidharan Kavitha , Lindblom Anna , Wei Ying , Ciociola Ester , Jamialahmadi Oveis , Pingitore Piero , Andréasson Anne-Christine , Pellegrini Giovanni , Baselli Guido , Männistö Ville , Pihlajamäki Jussi , Kärjä Vesa , Grimaudo Stefania , Marini Ilaria , Maggioni Marco , Becattini Barbara , Tavaglione Federica , Dix Carly , Castaldo Marie , Klein Stephanie , Perelis Mark , Pattou Francois , Thuillier Dorothée , Raverdy Violeta , Dongiovanni Paola , Fracanzani Anna Ludovica , Stickel Felix , Hampe Jochen , Buch Stephan , Luukkonen Panu K. , Prati Daniele , Yki-Järvinen Hannele , Petta Salvatore , Xing Chao , Schafmayer Clemens , Aigner Elmar , Datz Christian , Lee Richard G. , Valenti Luca , Lindén Daniel , Romeo Stefano
Published: January 2022

Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has a genetic component but, despite the common variants already identified, there is still a missing heritability component. Using a candidate gene approach, we identify a locus (rs71519934) at the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene resulting in a leucine to threonine substitution at position 186 of the protein (L186T) that reduces susceptibility to the entire spectrum of FLD in individuals at risk. PSD3 downregulation by short interfering RNA reduces intracellular lipid content in primary human hepatocytes cultured in two and three dimensions, and in human and rodent hepatoma cells. Consistent with this, Psd3 downregulation by antisense oligonucleotides in vivo protects against FLD in mice fed a non-alcoholic steatohepatitis-inducing diet. Thus, translating these results to humans, PSD3 downregulation might be a future therapeutic option for treating FLD.
Impact of the proximity effect on uranyl coordination of conformationally variable weakly-bonded cucurbit[6]uril-bipyridinium pseudorotaxane
Authors: Li Feize , Mei Lei , Peng Haiyue , Hu Kongqiu , Chai Zhifang , Liu Ning
Published: January 2022

In this work, it has been demonstrated that weakly-bonded CB[6]-bipyridinium pseudorotaxanes exhibit various coordination mode in the assembly with uranyl, resulting in abundant structure variety in the prepared uranyl compounds.
Molecular insights into the allosteric coupling mechanism between an agonist and two different transducers for μ-opioid receptors
Authors: Zhang Fuhui , Yuan Yuan , Chen Yichi , Chen Jianfang , Guo Yanzhi , Pu Xuemei
Published: January 2022

This article uses aMD coupled with PMF and PSN to study two ternary complex systems (DAMGO-μOR-G-protein and DAMGO-μOR-β-arrestin) in order to elucidate the allosteric coupling between the agonist and the two different transducers.
Specific lift-up behaviour of acetate-intercalated layered yttrium hydroxide interlayer in water: application for heterogeneous Brønsted base catalysts toward Knoevenagel reactions
Authors: Hara Takayoshi , Habe Maoko , Nakanishi Hikaru , Fujimura Takuya , Sasai Ryo , Moriyoshi Chikako , Kawaguchi Shogo , Ichikuni Nobuyuki , Shimazu Shogo
Published: January 2022

The basal (00l) plane of acetate-intercalated layered yttrium hydroxide (CH3COO−/Y-LRH), synthesised by an anion exchange using Cl−/Y-LRH as a parent material, increased in water, and the lifted-up layered structure was generated immediately.
Comparison of disinfection in intermittently mixed (6 am–6 pm) and continuously mixed high rate algal ponds treating domestic wastewater in winter
Authors: Cheng Ngai Ning , Fallowfield Howard John
Published: January 2022

Daytime-only and continuously mixed HRAPs had equivalent disinfection performance, compliant with reuse guidelines. Daytime-only mixing reduces energy demand and capital cost of wastewater treatment, promoting adoption of HRAPs in rural communities.
Association between functional foods and cardiometabolic health in a real-life setting: a longitudinal observational study using objective diet records from an electronic purchase system
Authors: Shirai Yoshiro , Sakuma Masae , Nagasaka Yuji , Takeda Naoki , Matsui Kunio , Nakamura Mieko
Published: January 2022

The association between functional foods and cardiometabolic measurements in real-life was objectively evaluated using an electronic purchasing system.
The fatty acid profiles of mixed fermented milk and its anti-inflammation properties in an LPS-induced RAW264.7 cell model
Authors: Yang Guo , Lu Qianqian , Cui Lei , Zong Manli , Guo Yuxing , Liu Lianliang , Pan Daodong , Wu Zhen
Published: January 2022

Anti-inflammatory properties of fermented milk by the release of polyunsaturated fatty acids and the possibility to develop functional fermented milk with intestinal inflammation prevention properties.
Effect of an infant formula containing sn-2 palmitate on fecal microbiota and metabolome profiles of healthy term infants: a randomized, double-blind, parallel, controlled study
Authors: Guo Danying , Li Fei , Zhao Jianxin , Zhang Hao , Liu Bryan , Pan Jiancun , Zhang Wei , Chen Wei , Xu Yajun , Jiang Shilong , Zhai Qixiao
Published: January 2022

Different infant diets have strong effects on child development and may engender variations in fecal microbiota and metabolites.
Depolymerization of lignin for biological conversion through sulfonation and a chelator-mediated Fenton reaction
Authors: Martinez Daniella V. , Rodriguez Alberto , Juarros Miranda A. , Martinez Estevan J. , Alam Todd M. , Simmons Blake A. , Sale Kenneth L. , Singer Steven W. , Kent Michael S.
Published: January 2022

A chelator-mediated Fenton reaction efficiently cleaves C–C bonds in sulfonated lignin at or near room temperature and the depolymerized streams are compatible with microbial conversion.
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics
Authors: Madhav Hari , Jameel Ehtesham , Rehan Mohammad , Hoda Nasimul
Published: January 2022

Chromones were proved as an important anti-neurodegenerative and neurogenesis agent. They act in numerous ways such as an efficient inhibitory activity against AChE, BuChE, MOA, Aβ aggregation, and neuroprotection activities.
A multiferroic iron arsenide monolayer
Authors: Xuan Xiaoyu , Yang Tingfan , Zhou Jian , Zhang Zhuhua , Guo Wanlin
Published: January 2022

A highly stable iron arsenide monolayer material is predicted to exhibit ferroelasticity and magnetism simultaneously.
Fabrication of a novel heteroepitaxial structure from an MOF-on-MOF architecture as a photocatalyst for highly efficient Cr(vi) reduction
Authors: Khosroshahi Negin , Darabi Goudarzi Moein , Safarifard Vahid
Published: January 2022

Ce-on-Zr-MOF-808, a novel MOF-on-MOF hybrid used for efficient chromium reduction under visible-light irradiation.
Templated synthesis of Ni(ii) complexes of unsymmetrical Schiff base ligands derived from 1,3-diamino-2-propanol: structural diversity and magnetic properties
Authors: Bhunia Pradip , Maity Souvik , Mayans Júlia , Ghosh Ashutosh
Published: January 2022

A Ferromagnetically coupled tetranuclear, an antiferromagnetically coupled hexanuclear and a mononuclear Ni(II) complex of new unsymmetrical Schiff base ligands derived from 1,3-diamino-2-propanol have been obtained with a slight change in the carbonyl compounds.
In vitro antitumor activity of dialkylamine-1,4-naphthoquinones toward human glioblastoma multiforme cells
Authors: Clementino-Neto José , da Silva João Kaycke Sarmento , de Melo Bastos Cavalcante Cibelle , da Silva-Júnior Paulo Fernando , David Cibelle Cabral , de Araújo Morgana Vital , Mendes Carmelita Bastos , de Queiroz Aline Cavalcanti , da Silva Elaine Cristina Oliveira , de Souza Samuel Teixeira , da Silva Fonseca Eduardo Jorge , da Silva Tânia Maria Sarmento , de Amorim Camara Celso , Moura-Neto Vivaldo , de Araújo-Júnior João Xavier , da Silva-Júnior Edeildo Ferreira , da-Silva Adriana Ximenes , Alexandre-Moreira Magna Suzana
Published: January 2022

In this study, we evaluated the in vitro antitumor activity of dialkylamino-1,4-naphthoquinones (1a–n) toward human glioblastoma multiforme cells (GBM02).
Sulfur-treated TiO2 shows improved alcohol dehydration activity and selectivity
Authors: R. Riscoe Andrew , Oh Jinwon , Cargnello Matteo
Published: January 2022

Alcohol dehydration is demonstrated on sulfur-treated titania with improved activity and selectivity.
The wavelength-dependent non-linear absorption and refraction of Au25 and Au38 monolayer-protected clusters
Authors: Su Zhicheng , Bejide Matias , Ferrari Piero , Kaw Kevin Anthony , Moris Michèle , Clays Koen , Knoppe Stefan , Lievens Peter , Janssens Ewald
Published: January 2022

Qualitative different non-linear optical phenomena with high nonlinear cross sections, as measured using the z-scan technique in combination with a tunable nanosecond laser source, were found at different excitation wavelengths.
ω-Unsaturated methacrylate macromonomers as reactive polymeric stabilizers in mini-emulsion polymerization
Authors: Booth Joshua R. , Davies Joshua D. , Bon Stefan A. F.
Published: January 2022

Mini-emulsion polymerizations stabilized by ω-unsaturated methacrylate macromonomers showed dimpled particle morphologies and in addition bimodal particle size distributions when high concentrations were used.
Electrochemical synthesis of dipyrazolo/dipyrimidine-fused pyridines via oxidative domino cyclization of C(sp3)–H bonds
Authors: Qian Peng , Xu Linna , Wang Wenyan , Zhang Lin , Tang Liang , Liu Jiaojiao , Sheng Liangquan
Published: January 2022

An electrochemically oxidative domino cyclization reaction of methyl azaarenes/ketones with pyrazol-5-amines and 6-amino-pyrimidine-2,4-diones was developed, providing a variety of dipyrazolo/dipyrimidine-fused pyridines with moderate to good yields.
Nitridation effect on lithium iron phosphate cathode for rechargeable batteries
Authors: Mayer Sergio Federico , de la Calle Cristina , Fernández-Díaz María Teresa , Amarilla José Manuel , Alonso José Antonio
Published: January 2022

A better-performing oxynitride with LFP olivine structure as an appealing intercalation cathode for lithium-ion batteries.
Computational investigation of a covalent triazine framework (CTF-0) as an efficient electrochemical sensor
Authors: Sarfaraz Sehrish , Yar Muhammad , Ans Muhammad , Gilani Mazhar Amjad , Ludwig Ralf , Hashmi Muhammad Ali , Hussain Masroor , Muhammad Shabbir , Ayub Khurshid
Published: January 2022

In the current study, a covalent triazine framework (CTF-0) was evaluated as an electrochemical sensor against industrial pollutantsi.e., O3, NO, SO2, SO3, and CO2.
Hydrothermally synthesized poorly-crystalline binary oxides with ZrW2O8composition: preparation, structural analysis, and catalytic activity for the alkylation of anisole with benzyl alcohol
Authors: Yamamoto Takashi , Heiuchi Seina , Kondo Maki , Tabusadani Kei , Sakaki Atsushi
Published: January 2022

Hydrothermally synthesized poorly-crystalline metastable Zr–W binary hydroxide (W/Zr = 2), after calcination, was confirmed to be a strong solid acid catalyst to promote the alkylation of anisole with benzyl alcohol.
Hexadecyl trimethyl ammonium bromide assisted growth of NiCo2O4@reduced graphene oxide/ nickel foam nanoneedle arrays with enhanced performance for supercapacitor electrodes
Authors: Liu Tingting , Zhou Shuai , Yu Xuehan , Mao Chao , Wei Yujie , Yu Xinyong , Chen Lei , Zhao Xin , Tian Guoxing , Chen Ling
Published: January 2022

Anisotropic NiCo2O4 nanoneedle arrays grew directly on Ni foam in the presence of rGO via the hydrothermal method followed by annealing assisted by hexadecyl trimethyl ammonium bromide (CTAB).
Facile synthesis of silver nanocatalyst decorated Fe3O4@PDA core–shell nanoparticles with enhanced catalytic properties and selectivity
Authors: Liu Yujie , Zhou Haijun , Wang Jinling , Yu Ding , Li Zhaolei , Liu Rui
Published: January 2022

In this work, we have successfully prepared core–shell nanoparticles (Fe3O4@PDA) wrapped with Ag using a simple and green synthesis method.
Nitrogen reduction reaction under ambient conditions by K3Ti8O17 nanorod electrocatalyst
Authors: Sebastian Meera , Das Subrata , Gopalan Nishanth Karimbintherikkal
Published: January 2022

K3Ti8O17 nanorods with excellent electrocatalytic activity for nitrogen reduction reaction at ambient conditions.
Boosting uniform charge distribution using 3D rigid electrodes with interconnected gyroid channels to achieve stable and reliable zinc-ion batteries
Authors: Zhang Minggang , Hu Taotao , Wang Xiao , Chang Peng , Jin Zhipeng , Pan Longkai , Mei Hui , Cheng Laifei , Zhang Litong
Published: January 2022

3D gyroid electrodes with excellent connectivity and rigidity boost uniform charge distribution within the 3D structure, achieving stable and reliable zinc ion batteries.
Disentangling the effect of doping chemistry on the energy storage properties of barium titanate ferroelectrics using data science tools
Authors: Yuan Ruihao , Xue Deqing , Li Jinshan , Xue Dezhen , Lookman Turab
Published: January 2022

Using data science tools including machine learning and statistical analysis, the effects of multiple chemical doping on the energy storage performance of barium titanate based ceramics are investigated from both quantitative and qualitative perspectives.
Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degenerationin vivo
Authors: Tandon Vasudha , Vala Ruturajsinh M. , Chen Albert , Sah Robert L. , Patel Hitendra M. , Pirrung Michael C. , Banerjee Sourav
Published: January 2022

Proteasome-addicted neoplastic malignancies present a considerable refractory and relapsed phenotype with patients exhibiting drug resistance and high mortality rates. To counter this global problem, novel proteasome-based therapies are being developed. In the current study, we extensively characterize TIR-199, a syrbactin-class proteasome inhibitor derived from a plant virulence factor of bacterium Pseudomonas syringae pv syringae. We report that TIR-199 is a potent constitutive and immunoproteasome inhibitor, capable of inducing cell death in multiple myeloma, triple-negative breast cancer, (TNBC) and non-small cell lung cancer lines. TIR-199 also effectively inhibits the proteasome in primary myeloma cells of patients, and bypasses the PSMB5 A49T+A50V bortezomib-resistant mutant. TIR-199 treatment leads to accumulation of canonical proteasome substrates in cells, it is specific, and does not inhibit 50 other enzymes tested in vitro. The drug exhibits synergistic cytotoxicity in combination with proteasome-activating kinase DYRK2 inhibitor LDN192960. Furthermore, low-doses of TIR-199 exhibits in vivo activity by delaying myeloma-mediated bone degeneration in a mouse xenograft model. Together, our data indicates that proteasome inhibitor TIR-199 could indeed be a promising next-generation drug within the repertoire of proteasome-based therapeutics.
A new approach for top‐oil thermal modelling of power transformers using Unscented Kalman filter considering IEEE C57.91 standard
Authors: Bagheri Alireza , Allahbakhshi Mehdi , Arefi Mohammad Mehdi , Najafi Nassim , Javadi Mohammad Sadegh
Published: January 2022

Determining the transformer top‐oil temperature (TOT) is one of the key issues in determining the transformer insulation life and reliability of the power system. Due to the non‐linear nature of the model presented in the IEEE C57.91 standard to determine this temperature, a more precise method is needed to estimate the equation coefficients to estimate the TOT in the future. This paper presents a method for online thermal modelling of the transformer according to the IEEE C57.91 based on the Unscented Kalman filter (UKF). This method can be applied to transformers with a variety of cooling modes and estimates the TOT with an acceptable error. In order to evaluate the proposed method, the practical data of the 800 kVA distribution transformer with unknown equation coefficients and simulated data with known coefficients are used, and finally, by calculating the estimation error, the proper performance of the presented method is proved. It is proved that the proposed method predicts TOT even in the presence of noise with an error of less than 0.5°C and a delay of less than 1.5 h. It makes the proposed method can be implemented for purposes such as load management, and insulation life estimation of the transformer.
A strip‐based total dissolved solids sensor for water quality analysis
Authors: Makhdoumi Akram Mohammad , Ramezannezhad Mohammad , Nikfarjam Alireza , Kabiri Shima , Ehyaei Sana
Published: January 2022

In this study, a portable Total Dissolved Solids (TDS) and Electrical Conductivity (EC) of water sensor using a disposable polymer strip and the readout circuit segments is presented. The strip consists of gold electrodes and a vent hole for water flow injection inside the measurement chamber. This strip reduces the cost of the measurement, decreases the measurement duration, and increases the repeatability of the system. Besides, there is no demand for electrodes cleaning and recalibration of the system. According to the electrical model of strip electrodes and their frequency responses, the EC value is in the range of 78.1–1230.8 (µs)/cm. The experimental tests are carried out based on the frequency method in the concentration range within 50–800 ppm. The results confirm the linear relation of TDS concentration on the EC voltage value which is 1.9 mV for 1 ppm resolution. Also, the effect of temperature variations on the EC value is investigated. Furthermore, the average amount of error for EC measurement exhibits an acceptable amount in comparison with other studies. Moreover, studying the drift variations for 20 days reveals the maximum drift of 1.6%. Finally, according to the present study, the sensor is a suitable candidate for practical applications.
Corona discharge actuator as an active sound absorber under normal and oblique incidence
Authors: Sergeev Stanislav , Humbert Thomas , Lissek Hervé , Aurégan Yves
Published: January 2022

In the majority of active sound absorbing systems, a conventional electrodynamic loudspeaker is used as a controlled source. However, particular situations may require an actuator that is more resistant to harsh environments, adjustable in shape, and lighter. In this work, a plasma-based electroacoustic actuator operating on the atmospheric corona discharge principle is used to achieve sound absorption in real-time. Two control strategies are introduced and tested for both normal in the impedance tube and grazing incidence in the flow duct. The performance of plasma-based active absorber is competitive with conventional passive technologies in terms of effective absorption bandwidth and low-frequency operation, however, it presents some inherent limitations that are discussed. The study reveals that the corona discharge technology is suitable for active noise control in ducts while offering flexibility in design, compactness, and versatility of the absorption frequency range.
Foliar application of kaolin and zeolites to adapt the adverse effects of climate change in Vitis vinifera L. cv. Sangiovese
Authors: Valentini Gabriele , Pastore Chiara , Allegro Gianluca , Mazzoleni Riccardo , Colucci Emilia , Filippetti Ilaria
Published: January 2022

One of the first effects of climate change in wine-growing areas is the advancement of phenological stages, especially concerning early berry ripening. In this condition, the decoupling between technological and phenolic maturity often occurs. Anthocyanins in red grapes are among the compounds that mostly contribute to phenolic maturity. However, their accumulation in the grape berries is known to be impaired by high temperatures. Therefore, this study aims to evaluate the efficacy of mineral-based compounds treatments with kaolin and zeolite, based on chabasite, on the enhancement of anthocyanins accumulation, also at the molecular level, analysing the gene expressions along the flavonoid biosynthesis pathway during ripening of Sangiovese berries. In addition, the temperature of berries and grape leaves, vine water status, leaf photosynthetic efficiency, total soluble solids, titratable acidity and pH were measured throughout the growing season. Hence, in the current study, it has been demonstrated the efficacy of kaolin and zeolite treatments not only in lowering the daily maximum grape berries temperature but also in the improvement of grapes anthocyanins accumulation correlated with the enhancement of expression of those genes involved in their biosynthesis pathway. Moreover, treatments had no significant effect on productive parameters.
Zeowine: The synergy of zeolite and compost. Effects on the physiology of the vine and on the quality of the grapes
Authors: Cataldo Eleonora , Salvi Linda , Sbraci Sofia , Manzi Davide , Masciandaro Grazia , Masini Cosimo Maria , Mattii Giovan Battista
Published: January 2022

The trial aims to improve the protection and management of the soil, the well-being of the plant and the quality of production in the wine supply chain organic and biodynamic, using an innovative product “ZEOWINE” resulting from the composting of waste of the wine and zeolite supply chain. At present, the use of zeolites in agriculture is a fast-spreading practice; their application to soils (both as natural zeolites and in combination with organic and mineral fertilizers) not only increases production but also leads to the exaltation of quality indices. The research was conducted in the 2019 season in San Miniato (Tuscany) on the vineyard of Sangiovese in production, performing the following inter-row treatments at the beginning of January: commercial organic fertilizer, zeolite (clinopthylolite) and zeowine (combination zeolite and compost obtained through grape processing waste) in the respective doses of 20 t/ha, 10 t/ha and 30 t/ha. Following the treatment, we measured gas exchanges and water potential, berry weight, °Brix, pH, acidity, total and extractable anthocyanins and polyphenols. Treatments with Zeowine and zeolites reduced water stress. In Zeowine treatment, soluble solids were lower, while acidity, pH and berry weight do not vary from control. Statistical differences are also noted in the concentrations of anthocyanins and polyphenols. Results suggest a positive impact of Zeowine treatment on physiology and quality characteristics in V. vinifera.
The Relationship between an Accessory Maxillary Ostium and Variations in Structures Adjacent to the Maxillary Sinus without Polyps
Authors: Serindere Gozde , Gunduz Kaan , Avsever Hakan
Published: January 2022

Introduction The maxillary sinus and its variations are very important to dentistry and rhinology.

Objective To investigate the effect of the accessory maxillary ostium (AMO) on the variations of adjacent structures of the maxillary sinus.

Methods The computed tomography (CT) images of 400 patients were retrospectively evaluated. The prevalence of AMO was calculated. The relationship between morphological variations of adjacent structures of maxillary sinus such as agger nasi cell (ANC), Haller cell (HC), nasal septum deviation (NSD), hypertrophy of inferior concha (HIC), pneumatization of middle concha (PMC), mucus retention cyst (MRC), mucosal thickening (MT), and maxillary sinusitis (MS), as well as the presence of AMO, were investigated.

Results Presence of AMO was diagnosed in 42 patients (10.5%), having been found in 4.5% of the patients only on the right side, in 1.25% of the patients only on the left side, and in 4.75% of the patients on both sides. There is an increasing incidence of ANC, HC, NSD, HIC, and PMC in the presence of AMO and MS. There is a decreasing incidence of MRC in the presence of AMO. Furthermore, AMO does not affect the incidence of MT.

Conclusion This study showed that most parameters, except for MRC and MT, had increasing incidence in the presence of AMO. It is important for radiologists and rhinologists to have knowledge about the location of AMO and the presence of variations of MS adjacent structures to avoid surgical complications.
Atomic force microscopy reveals distinct protofilament-scale structural dynamics in depolymerizing microtubule arrays
Authors: Wijeratne Sithara S. , Marchan Michelle F. , Tresback Jason S. , Subramanian Radhika
Published: January 2022

Significance

One cannot help but marvel at the precise organization of microtubule polymers in cellular structures such as the axoneme and the spindle. However, our understanding of the biochemical mechanisms that sculpt these arrays comes largely from in vitro experiments with a small number (one or two) of microtubules. This is somewhat akin to studying the architecture of multilane highways by studying one-lane streets. Here, we directly visualize depolymerizing microtubule arrays at individual microtubule and protofilament resolution using atomic force microscopy. Our results reveal differences in microtubule depolymerase activity and provide insights into how these differences in enzymatic activity on the nanometer scale can result in the differential remodeling of multimicrotubule arrays on the micron-length scale.
Strong evidence for a weakly oxygenated ocean–atmosphere system during the Proterozoic
Authors: Wang Changle , Lechte Maxwell A. , Reinhard Christopher T. , Asael Dan , Cole Devon B. , Halverson Galen P. , Porter Susannah M. , Galili Nir , Halevy Itay , Rainbird Robert H. , Lyons Timothy W. , Planavsky Noah J.
Published: January 2022

Significance

Earth’s transition from anoxic oceans and atmosphere to a well-oxygenated state led to major changes in nearly every surficial system. However, estimates of surface oxygen levels in the billion years preceding this shift span two orders of magnitude, suggesting a poor understanding of the evolution of the oxygen cycle. We use the isotopic record of iron oxides deposited in ancient shallow marine environments to show that oxygen remained at extremely low levels in the ocean–atmosphere system for most of Earth’s history, and that a rise in oxygen occurred in step with the expansion of complex, eukaryotic ecosystems. These results indicate that Earth is capable of stabilizing at low atmospheric oxygen levels, with important implications for exploration of exoplanet biosignatures.
ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits
Authors: Liu Dongmei , Mari Muriel , Li Xia , Reggiori Fulvio , Ferro-Novick Susan , Novick Peter
Published: January 2022

Significance

Portions of the endoplasmic reticulum (ER) are degraded by autophagy (ER-phagy) in response to starvation or the accumulation of misfolded proteins. We show that ER-phagy requires assembly of actin at sites of contact between the edges of ER sheets and endocytic pits on the plasma membrane. Actin assembly may help to bring an element of the ER carrying the selective autophagy receptor Atg40 into the cell interior, where it associates with Atg11, a scaffold needed to recruit components for autophagosome assembly. Understanding the mechanism by which regions of the ER are selected for degradation and sequestered within autophagosomes may help in the development of novel approaches to treat diseases that result from the accumulation of misfolded proteins within the ER.