bluuebunny/crossref_metadata_2025 huggingface dataset:
The Probability of Hospital Bankruptcy: A Stochastic Approach
Authors: Shanmugam Ramalingam , Beauvais Brad , Dolezel Diane , Pradhan Rohit , Ramamonjiarivelo Zo
Published: August 2024

Healthcare leaders are faced with many financial challenges in the contemporary environment, leading to financial distress and notable instances of bankruptcies in recent years. What is not well understood are the specific conditions that may lead to organizational economic failure. Though there are various models that predict financial distress, existing regression methods may be inadequate, especially when the finance variables follow a nonnormal frequency pattern. Furthermore, the regression approach encounters difficulties due to multicollinearity. Therefore, an alternate stochastic approach for predicting the probability of hospital bankruptcy is needed. The new method we propose involves several key steps to better assess financial health in hospitals. First, we compute and interpret the relationship between the hospital’s revenues and expenses for bivariate lognormal data. Next, we estimate the risk of bankruptcy due to the mismatch between revenues and expenses. We also determine the likelihood of a hospital’s expenses exceeding the state’s median expenses level. Lastly, we evaluate the hospital’s financial memory level to understand its level of financial stability. We believe that our novel approach to anticipating hospital bankruptcy may be useful for both hospital leaders and policymakers in making informed decisions and proactively managing risks to ensure the sustainability and stability of their institutions.
Breaking the Boundaries in the Digital Age: Open Banking and Tax Evasion
Authors: Dang Ngoc Thang , Andreadakis Stelios , Nika Pamela , Nandy Monomita
Published: August 2024

In this paper, we examine the relationship between open banking and tax evasion. As the open banking literature is still evolving, we try to systematically analyze the literature on conventional banking and tax evasion and then extend the discussion in the context of open banking. The popularity of open baking recently raises a question about its relationship with tax evasion. Digital banking and digital taxation contributed positively to mitigating tax evasion in the context of conventional banking. However, in open banking, the customers can decide to what extent they will share any transaction-related data with their bank, while they can also choose to complete direct transactions with third parties. This creates a new challenge in relation to the mitigation of tax evasion, which is the focus of this paper. Due to lack of granular empirical data, we conduct a systematic literature review and a bibliometric analysis to track the development of the relevant academic debates and identify the arguments that have been presented in relation to this topic. This approach is recognized as well suited for emerging topics in finance research, particularly when data are scarce, as evidenced by studies on COVID-19 and biodiversity. We find that the gaps of the current regulatory framework, at both the national and supranational level, have created challenges and uncertainties at multiple levels. Nonetheless, the findings of the study suggest future research directions and offer valuable guidelines for regulators in utilizing open banking.
Integrated Multi-Omics Analysis Reveals Mountain-Cultivated Ginseng Ameliorates Cold-Stimulated Steroid-Resistant Asthma by Regulating Interactions among Microbiota, Genes, and Metabolites
Authors: Tang Daohao , Wang Chao , Liu Hanlin , Wu Junzhe , Tan Luying , Liu Sihan , Lv Haoming , Wang Cuizhu , Wang Fang , Liu Jinping
Published: August 2024

Steroid-resistant asthma (SRA), resisting glucocorticoids such as dexamethasone (DEX), is a bottleneck in the treatment of asthma. It is characterized by a predominantly neutrophilic inflammatory subtype and is prone to developing into severe refractory asthma and fatal asthma. Currently, there is a lack of universally effective treatments for SRA. Moreover, since cold stimulation does increase the risk of asthma development and exacerbate asthma symptoms, the treatment of cold-stimulated SRA (CSRA) will face greater challenges. To find effective new methods to ameliorate CSRA, this study established a CSRA mouse model of allergic airway inflammation mimicking human asthma for the first time and evaluated the alleviating effects of 80% ethanol extract of mountain-cultivated ginseng (MCG) based on multi-omics analysis. The results indicate that cold stimulation indeed exacerbated the SRA-related symptoms in mice; the DEX individual treatment did not show a satisfactory effect; while the combination treatment of DEX and MCG could dose-dependently significantly enhance the lung function; reduce neutrophil aggregation; decrease the levels of LPS, IFN-γ, IL-1β, CXCL8, and IL-17; increase the level of IL-10; alleviate the inflammatory infiltration; and decrease the mucus secretion and the expression of MUC5AC. Moreover, the combination of DEX and high-dose (200 mg/kg) MCG could significantly increase the levels of tight junction proteins (TJs), regulate the disordered intestinal flora, increase the content of short-chain fatty acids (SCFAs), and regulate the abnormal gene profile and metabolic profile. Multi-omics integrated analysis showed that 7 gut microbes, 34 genes, 6 metabolites, and the involved 15 metabolic/signaling pathways were closely related to the pharmacological effects of combination therapy. In conclusion, integrated multi-omics profiling highlighted the benefits of MCG for CSRA mice by modulating the interactions of microbiota, genes, and metabolites. MCG shows great potential as a functional food in the adjuvant treatment of CSRA.
A Lightweight Crop Pest Detection Method Based on Improved RTMDet
Authors: Wang Wanqing , Fu Haoyue
Published: August 2024

To address the issues of low detection accuracy and large model parameters in crop pest detection in natural scenes, this study improves the deep learning object detection model and proposes a lightweight and accurate method RTMDet++ for crop pest detection. First, the real-time object detection network RTMDet is utilized to design the pest detection model. Then, the backbone and neck structures are pruned to reduce the number of parameters and computation. Subsequently, a shortcut connection module is added to the classification and regression branches, respectively, to enhance its feature learning capability, thereby improving its accuracy. Experimental results show that, compared to the original model RTMDet, the improved model RTMDet++ reduces the number of parameters by 15.5%, the computation by 25.0%, and improves the mean average precision by 0.3% on the crop pest dataset IP102. The improved model RTMDet++ achieves a mAP of 94.1%, a precision of 92.5%, and a recall of 92.7% with 4.117M parameters and 3.130G computations, outperforming other object detection methods. The proposed model RTMDet++ achieves higher performance with fewer parameters and computations, which can be applied to crop pest detection in practice and aids in pest control research.
TEADASH: Implementing and Evaluating a Teacher-Facing Dashboard Using Design Science Research
Authors: Nguyen Ngoc Buu Cat , Lithander Marcus , Östlund Christian Master , Karunaratne Thashmee , Jobe William
Published: August 2024

The benefits of teacher-facing dashboards are incontestable, yet their evidence is finite in terms of long-term use, meaningful usability, and maturity level. Thus, this paper uses design science research and critical theory to design and develop TEADASH to support teachers in making decisions on teaching and learning. Three cycles of design science research and multiple small loops were implemented to develop the dashboard. The tool was then deployed and evaluated in real time with the authentic courses. Five courses from two Swedish universities were included in this study. The co-design with teachers is crucial to the applicability of this dashboard, while letting teachers use the tool during their courses is more important to help them to recognize the features they actually use and the tool’s usefulness for their teaching practices. TEADASH can address the prior matters, align with the learning design, and meet teachers’ needs. The technical and co-design aspects, as well as the advantages and challenges of applying TEADASH in practice, are also discussed here.
Numerical Investigation of the Axial Load Capacity of Cold-Formed Steel Channel Sections: Effects of Eccentricity, Section Thickness, and Column Length
Authors: Hussein Diyari B. , Hussein Ardalan B.
Published: August 2024

Cold-formed steel channel (CFSC) sections have gained widespread adoption in building construction due to their advantageous properties, including superior energy efficiency, expedited construction timelines, environmental sustainability, material efficiency, and ease of transportation. This study presents a numerical investigation into the axial compressive behavior of CFSC section columns. A rigorously developed finite element model for CFSC sections was validated against existing experimental data from the literature. Upon validation, the model was employed for an extensive parametric analysis encompassing a dataset of 208 CFSC members. Furthermore, the efficacy of the design methodologies outlined in the AISI Specification and AS/NZS Standard were evaluated by comparing the axial load capacities obtained from the numerically generated data with the results of four previously conducted experimental tests. The findings reveal that the codified design equations, based on nominal compressive resistances determined using the current direct strength method, exhibit a conservative bias. On average, these equations underestimate the actual load capacities of CFSC section columns by approximately 11.5%. Additionally, this investigation explores the influence of eccentricity, cross-sectional dimensions, and the point-of-load application on the axial load capacity of CFSC columns. The results demonstrate that a decrease in section thickness, an increase in column length, and a higher degree of eccentricity significantly reduce the axial capacity of CFSC columns.
Enhancing Dam Safety: Statistical Assessment and Kalman Filter for the Geodetic Network of Mosul Dam
Authors: Alsadik Bashar , Mahdi Hussein Alwan
Published: August 2024

Dams play a pivotal role in providing essential services such as energy generation, water supply, and flood control. However, their stability is crucial, and continuous monitoring is vital to mitigate potential risks. The Mosul Dam is one of the most interesting infrastructures in Iraq because it was constructed on alternating beds of karstified and gypsum which required continuous grouting due to water seepage. Therefore, the ongoing maintenance issues raised international concerns about its stability. For several years the dam indicated a potential for disastrous failure that could cause massive flooding downstream and pose a serious threat to millions of people. This research focuses on comprehensive statistical assessments of the dam geodetic network points across multiple epochs of long duration. Through the systematic application of three statistical tests and the predictive capabilities of the Kalman filter, safety and long-term stability are aimed to be enhanced. The analysis of the dam’s geodetic network points shows a consistent trend of upstream-to-downstream movement. The Kalman filter demonstrates promising outcomes for displacement prediction compared to least squares adjustment. This research provides valuable insights into dam stability assessment, aligns with established procedures, and contributes to the resilience and safety of critical infrastructure. The outcome of this paper can encourage future studies to build upon the foundation presented.
Screening and Identification of Protease-Producing Microorganisms in the Gut of Gryllotalpa orientalis (Orthoptera: Gryllotalpidae)
Authors: Zheng Xiang , Zhao Lu , Wu Fangtong , Zhou He , Shi Fuming
Published: August 2024

The insect gut harbors a diverse array of functional microorganisms that warrant further exploration and utilization. However, there is currently a paucity of research reports on the discovery of protease-producing microorganisms with industrial application value in the gut. Here, we employed microbial culturing to screen and identify the protease-producing microorganisms in the gut extract of Gryllotalpa orientalis. Based on morphological, physiological, and biochemical characterization, 16S rRNA sequencing, as well as ANI and dDDH values of whole genome, the protease-producing strains isolated from the insect gut were identified as Priestia aryahattai DBM-1 and DX-4, P. megaterium DX-3, and Serratia surfactantfaciens DBM-5. According to whole-genome analysis, strain DBM-5, which exhibited the highest enzyme activity, possesses abundant membrane transport genes and carbohydrate metabolism enzymes. In contrast, strains DX-3 and DX-4 not only have the ability to hydrolyze proteins but also demonstrate the capability to hydrolyze plant materials. Furthermore, strains that are closely related tend to have similar metabolic product gene clusters in their genomes. The screening and identification of protease resources are essential for the subsequent development and utilization of gut functional microorganisms and genetic resources in insects.
Home Monitoring Tools to Support Tracking Patients with Cardio–Cerebrovascular Diseases: Scientometric Review
Authors: Restrepo-Parra Elisabeth , Ariza-Colpas Paola Patricia , Torres-Bonilla Laura Valentina , Piñeres-Melo Marlon Alberto , Urina-Triana Miguel Alberto , Butt-Aziz Shariq
Published: August 2024

Home care and telemedicine are crucial for physical and mental health. Although there is a lot of information on these topics, it is scattered across various sources, making it difficult to identify key contributions and authors. This study conducts a scientometric analysis to consolidate the most relevant information. The methodology is divided into two parts: first, a scientometric mapping that analyzes scientific production by country, journal, and author; second, the identification of prominent contributions using the Tree of Science (ToS) tool. The goal is to identify trends and support decision-making in the health sector by providing guidelines based on the most relevant research.
Assessment of Corneal Graft Outcomes in a Murine Model of Endothelial Keratoplasty
Authors: Narimatsu Akitomo , Singh Rohan Bir , Surico Pier Luigi , Lee Seokjoo , Forouzanfar Katayoon , Kahale Francesca , Musayeva Aytan , Dohlman Thomas H. , Blanco Tomas , Dana Reza
Published: August 2024

Objectives: In this study, we establish a protocol for evaluating the outcomes of endothelial keratoplasty, including graft survival, rejection, or failure. Additionally, we also evaluate the alloimmune response in graft recipients. Methods: We performed EK using C57BL/6 (allogeneic) and BALB/c (syngeneic) as donors and BALB/c mice as recipients. Slit-lamp examination and optical coherence tomography were performed for clinical evaluations for 16 weeks post-procedure. Criteria for the assessment of corneal opacity were established and the animals were graded weekly. Additionally, we assessed corneal endothelial cell density by harvesting the corneas and staining with zonula occludens-1 (ZO-1). Lastly, lymph nodes were collected, and CD4+ T cells were MACS-sorted and co-cultured with syngeneic or allogeneic antigen-presenting cells (APCs) to assess the IFN-γ expression levels by alloreactive Th1 cells (ELISPOT) in response to the direct (donor) or indirect (host) pathways of sensitization. Results: We observed graft failure in four animals, including irreversible corneal opacity, graft detachment, and anterior synechiae in the first four weeks. The remaining animals were graded between 0 and 5 as per the established criteria. The total and graft corneal thickness and endothelial cell density progressively worsened with a higher grade of corneal opacity. The direct allosensitization of Th1 cells was significantly higher in mice with a higher grade of corneal opacity. At 16 weeks follow-up, the grafts remained stable with low opacity scores in syngeneic EK recipients; however, the opacity scores were higher and variable in allogeneic EK recipients. Conclusions: These findings establish a standardized protocol to assess the graft outcomes in a murine model of EK. Furthermore, we delineate the underlying immunological pathway that contributes to the immune-mediated rejection of grafts in this model.
Approaching Ventricular Tachycardia Ablation in 2024: An Update on Mapping and Ablation Strategies, Timing, and Future Directions
Authors: Di Cori Andrea , Pistelli Lorenzo , Parollo Matteo , Zaurino Nicola , Segreti Luca , Zucchelli Giulio
Published: August 2024

This review provides insights into mapping and ablation strategies for VT, offering a comprehensive overview of contemporary approaches and future perspectives in the field. The strengths and limitations of classical mapping strategies, namely activation mapping, pace mapping, entrainment mapping, and substrate mapping, are deeply discussed. The increasing pivotal relevance of CMR and MDCT in substrate definition is highlighted, particularly in defining the border zone, tissue channels, and fat. The integration of CMR and MDCT images with EAM is explored, with a special focus on their role in enhancing effectiveness and procedure safety. The abstract concludes by illustrating the Pisa workflow for the VT ablation procedure.
Chronotype Differences and Symptom Network Dynamics of Post-Pandemic Sleep in Adolescents and Young Adults
Authors: Windal Maxime , Roland Aurore , Laeremans Marise , Briganti Giovanni , Kornreich Charles , Mairesse Olivier
Published: August 2024

Background: Social restrictions during the COVID-19 pandemic resulted in altered sleep patterns and mental health challenges, particularly among adolescents and young adults. Our objective was to examine the potential difference in insomnia prevalence and sleep patterns in this population between the first COVID-19 lockdown and the post-lockdown period, with a focus on chronotype. Additionally, we explored the network of sleep-related differences between these two periods. Methods: A total of 946 respondents participated in our online questionnaire. We performed mixed ANOVA, Ising network and Directed Acyclic Graph (DAG) analyses. Results: Respondents reported going to bed earlier, waking up earlier, sleeping less, and feeling less mentally tired than during the lockdown. The severity of insomnia symptoms did not change. The lethargic chronotype reported more insomnia symptoms, depressive feelings, and agitation than others. Mental fatigue was the central symptom in the Ising network and served as the parent node in the DAG. Conclusions: Post-lockdown, adolescents and young adults have shifted to earlier sleep and wake times with reduced overall sleep, and they experience fewer depressive feelings and less agitation, though insomnia symptoms remain unchanged. Participants who reported increased irritability or poorer sleep quality during confinement also reported similar or diminished attentional capacities compared to their usual levels.
Effect of Waiting Period on Initial Adverse Vaginal Microbiome Composition in IVF-ICSI Patients
Authors: Bielfeld Alexandra Petra , Baston-Buest Dunja Maria , Edimiris Philippos , Kruessel Jan-Steffen
Published: August 2024

Background/Objectives: In this observational prospective cohort study, conducted at the Fertility Centre of the University Hospital, Duesseldorf Germany, the spontaneous reversal capacity and the effect of waiting time on an adverse vaginal microbiome profile in subfertile patients were investigated. Methods: Vaginal swabs of 76 patients were obtained before starting a fertility treatment using a commercially available test to perform a microbiome analysis. Patients with a favorable microbiome profile (“medium” or “high profile”) according to the manufacturer’s algorithm proceeded with the fertility treatment. Patients with an unfavorable microbiome profile (“low profile”) postponed their fertility treatment and were sampled up to four times in each successive cycle or until a shift to a more favorable profile was detected. Results: Initially, 54/76 subjects had a high or medium profile and 23/76 had a low profile. Within 3 months, 75% of patients with an initial low profile shifted to a more favorable profile (7/23 dropouts). The presence of Lactobacillus crispatus in the initial sample was associated with a higher likelihood of a spontaneous shift to a more favorable profile. Conclusions: The vaginal microbiome is subject to strong fluctuations. Even an unfavorable microbiome profile can develop into a favorable microbiome profile within a few months without treatment.
Evaluation of Acute Terminal Ileitis in Hospitalized Patients: Development of a Predictive Model to Distinguish Crohn’s Disease from Other Etiologies
Authors: Bermont Anton , Abu-Freha Naim , Aminov Refael , Vosko Sergei , Shirin Haim , Cohen Daniel L.
Published: August 2024

Background/Objectives: Terminal ileitis (TI) is often identified on CT scans in emergency settings. Diagnosing Crohn’s disease (CD) as a cause of TI is crucial due to its significant long-term implications. This study aimed to differentiate CD from other causes of acute TI and develop a predictive model for CD diagnosis. Methods: A retrospective case-control study was conducted at Shamir Medical Center including adults diagnosed with acute TI from January 2012 to December 2020. Patients with a history of inflammatory bowel disease or prior intestinal surgery were excluded. Patients were categorized into CD and non-CD groups based on their subsequent clinical course. A logistic regression model was developed and subsequently validated with additional patients hospitalized between 2021 and 2023. Results: Among 135 patients, 37 (27.4%) were diagnosed with CD. CD patients were younger (median age 27 vs. 39 years, p = 0.003), predominantly male (83.8% vs. 51%, p = 0.001), and had higher rates of chronic abdominal pain, diarrhea, anemia, and weight loss prior to hospitalization. Significant laboratory differences included higher platelet counts (p = 0.006) and lower mean corpuscular volume (MCV) (p = 0.001) in CD patients. Radiologic signs of complicated disease were more common in CD (35.1% vs. 4.1%, p < 0.001). The predictive model incorporating gender, abdominal pain history, and MCV showed an area under the curve (AUC) of 0.87, with a sensitivity of 100% and specificity of 63.6% in the validation group of 18 patients. Conclusions: This study identified key predictors of CD in patients presenting with acute TI and developed a predictive model with a substantial diagnostic capability. Use of this model for early identification and treatment of CD may potentially improve patient outcomes. Further prospective validation of this model is warranted.
Effect of Diflunisal in Patients with Transthyretin Cardiomyopathy: A Pilot Study
Authors: Camblor Blasco Andrea , Devesa Ana , Nieto Roca Luis , Gómez-Talavera Sandra , Lumpuy-Castillo Jairo , Pello Lázaro Ana María , Llanos Jiménez Lucía , Sánchez González Javier , Lorenzo Óscar , Tuñón Jose , Ibáñez Borja , Aceña Álvaro
Published: August 2024

Background: ATTR-CM is becoming more prevalent, and disease-modifying therapy has been investigated in recent years with promising results. Diflunisal has shown TTR-stabilizing properties assessed by biomarkers and echocardiography, but there are no trials addressing the evolution of morphological changes with CMR. Methods and Results: AMILCA-DIFLU is an exploratory pilot study prospective, single-center, non-randomized, open-label clinical trial. Patients diagnosed with ATTR-CM underwent clinical, functional, biochemical and imaging assessment before and one year after diflunisal therapy initiation. Of the twelve ATTR-CM patients included, only nine patients completed treatment and study protocol in 12 months. To increase the sample size, we included seven real-world patients with one year of diflunisal treatment. Among the group of patients who completed treatment, diflunisal therapy did not show improvement in cardiac disease status as assessed by many cardiac and inflammatory biomarkers, 6MWT and CMR parameters after one year of treatment. However, a non-significant trend towards stabilization of CMR parameters such as LVEF, ECV and T2 at one year was found. When comparing the group of patients who completed diflunisal therapy and those who did not, a significant decrease in the distance performed in the 6MWT was found in the group of patients who completed treatment at one year (−14 ± 81.8 vs. −173 ± 122.2; p = 0.032). Diflunisal was overall well tolerated, showing only a statistically significant worsening in renal function in the group of diflunisal-treatment patients with no clinical relevance or need for treatment discontinuation. Conclusions: In patients with ATTR-CM, treatment with diflunisal was overall well tolerated and tended to stabilize or slow down amyloid cardiac disease progression assessed by CMR parameters, cardiac and inflammatory biomarkers and functional capacity.
Analysis of the Clinical Value of Laparoscopic Sacrocolpopexy to Support the Posterior Compartment in Women with Multicompartment Prolapse Including Rectocele
Authors: Aichner Simone , Studer Andreas , Frey Janine , Brambs Christine , Krebs Jörg , Christmann-Schmid Corina
Published: August 2024

Background/Objectives: Laparoscopic sacrocolpopexy is regarded as the gold standard treatment for apical or multicompartment prolapse, predominantly with anterior compartment descent. However, the optimal surgical approach for concurrent rectocele is still debated. The aim of this study was to evaluate the effectiveness of nerve-sparing laparoscopic sacrocolpopexy in managing multicompartment prolapse with concurrent rectocele (≥stage II), analyzing the anatomical outcomes, the necessity for concomitant or subsequent posterior repair, and the impact on bowel function in women undergoing surgery. Methods: Data from all women who underwent laparoscopic sacrocolpopexy with or without posterior repair between 01/2017 and 07/2022 for symptomatic multicompartment prolapse, including apical and posterior compartment descent ≥ stage II, were retrospectively evaluated. All women underwent a standardized urogynecological examination, including assessment of genital prolapse using the POP-Q quantification system, and completed the German-validated Australian Pelvic Floor Questionnaire before and after surgery (6–12 weeks). Preoperative anatomic support and bowel symptoms were compared with postoperative values. Results: In total, 112 women met the criteria for surgical correction. The majority (87%) had stage II posterior descent, with only 10% undergoing concurrent posterior repair during laparoscopic sacrocolpopexy. Significant (p < 0.001) objective improvement was seen for all compartments post- compared with preoperatively (Ba: 0 (−1/2) vs. −3 (−3/−2), C: −1 (−2/0) vs. −8 (−12/−7), Bp: 0 (−1/0) vs. −3 (−2/−2); (median (25%/75% quartiles)). Subsequent surgery for persistent rectocele and/or stool outlet symptoms was required in 4% of cases. Most bowel-specific questions in the German-validated Australian Pelvic Floor Questionnaire showed significant improvement (p < 0.001). Conclusions: Nerve-sparing sacrocolpopexy alone appears to be a suitable surgical approach to correct multicompartment prolapse, including a rectocele ≥ stage II, and results in a reduction of objective signs and symptoms of pelvic organ prolapse.
Reconstruction of Chronic Soft Tissue Mallet Fingers: Outcomes of Step-Plasty vs. Purse-String Suture
Authors: Demmer Wolfram , Frick Andreas , Baumeister Rüdiger G. H. , Haas-Lützenberger Elisabeth , Thierfelder Nikolaus , Mert Sinan , Ehrl Denis , Giunta Riccardo , Stäuble Christiane G.
Published: August 2024

After failed conservative therapy or in the absence of any intervention, a rupture of the digital subcutaneous extensor tendon at the distal interphalangeal (DIP) joint, known as mallet finger, may lead to a chronic extension deficit due to excessive scarring and tendon elongation. Various surgical techniques to restore the extension of the distal phalanx have been proposed, but an optimal approach has not yet been established. To tighten the extensor tendon, a purse-string suture can be applied. Although it has shown efficacy, it can result in significant bulging and scar formation. Using the “abbreviato” technique, the elongated part of the extensor tendon is excised, and the tendon is re-sutured. Also, tenodesis has been described, particularly in pediatric cases. In this retrospective follow-up study, we aimed to investigate if the step-plasty procedure previously described by Baumeister provides comparable, if not superior, functional and aesthetic outcomes compared to existing techniques for patients with chronic mallet finger. In this retrospective study, a consecutive series of 68 patients with chronic mallet fingers was enrolled. Patients were treated surgically using step-plasty of the respective extensor tendon. After skin incision and tenolysis, the elongated extensor tendon was incised in a Z-like fashion and stepwise resected in the transverse portion of the Z. The functional and aesthetic effects of this step-plasty technique were compared with results of 44 patients previously treated using purse-string sutures of the extensor tendon and evaluated using Crawford’s and Levante’s criteria. In all patients undergoing the step-plasty procedure, the extension deficit was significantly reduced from an average of 42 degrees preoperatively to 11 degrees postoperatively. In contrast, the control group treated by purse-string sutures showed a slightly higher postoperative extension deficit of 15 degrees. According to Levante’s criteria, the results of our step-plasty procedure were significantly better than those achieved with purse-string sutures. Our study demonstrated that the treatment of older or chronic subcutaneous extensor tendon ruptures using the step-plasty technique led to a significant reduction in extension deficits. According to Levante’s criteria, the postoperative outcome was significantly better in comparison to the purse-string suture technique. Additionally, no skin resection was required to improve the extension capability of the distal finger joint, compared to established surgical procedures.
A Practical Guide to Injection Therapy in Hand Tendinopathies: A Systematic Review of Randomized Controlled Trials
Authors: Frizziero Antonio , Maffulli Nicola , Saglietti Chiara , Sarti Eugenio , Bigliardi Davide , Costantino Cosimo , Demeco Andrea
Published: August 2024

Hand tendinopathies represent a pathological condition associated with significant disability. However, due to this high heterogeneity of the treatments and their efficacy, there is still a lack of consensus on the infiltrative therapy of the hand. This systematic review aimed to investigate the efficacy of injection techniques in the treatment of pain related to the main hand tendinopathies. We searched online medical databases (PubMed, Pedro, Cochrane Library, Scopus, and WoS). Only RCTs published in the last 10 years (up to 5 August 2024), written in English, and related to infiltrative treatment in wrist and hand tendinopathies were evaluated. The risk of bias in RCTs was assessed with Version 2 of the Cochrane Risk of Bias tool for randomized trials (RoB 2). Out of 641 articles identified, 23 were included in the final synthesis: 14 RCTs on trigger finger, and 9 RCTs on de Quervain’s tenosynovitis. The present systematic review showed that infiltrative therapy of trigger finger and de Quervain’s tenosynovitis constitutes a fundamental element in the treatment of these pathological conditions, in terms of pain reduction and improvement in the functionality of the hand.
Research on the Power Output of Different Floating Wind Farms Considering the Wake Effect
Authors: Cui Jiaping , Wu Xianyou , Lyu Pin , Zhao Tong , Li Quankun , Ma Ruixian , Liu Yingming
Published: August 2024

For floating wind turbines, one of the most interesting and challenging issues is that the movement of the rotor is strongly related to its floating platform, which results in corresponding variations in the wake characteristics of the turbine. Because the aerodynamic efficiency of the downstream turbines is affected by the wake characteristics, the power output will consequently vary depending on the different types of floating wind turbines and floating wind farms used. In this study, the rotor movement, wake characteristics, and corresponding wind farm power output are analyzed using a numerical method for three typical floating wind turbines: the semisubmersible type, spar buoy type, and tension leg platform type with a 5 MW configuration. A fixed-bottom monopile wind turbine is adopted as a benchmark. The simulation results show that of the three floating wind turbines, the rotor position and wake center are most dispersed in the case of the spar buoy type, and its wake also has the lowest impact on downstream wind turbines. Additionally, the power output of the corresponding spar buoy type wind farm is also the highest at different wind speeds, followed by the semisubmersible type, tension leg platform type, and then the fixed-bottom type. In particular, at low wind speeds, the wake effects differ significantly among the various types of wind turbines.
Inception of Constructional Submarine Conduit by Asymmetry Generated by Turbidity Current
Authors: Bayer da Silva Daniel , Puhl Eduardo , Manica Rafael , de Oliveira Borges Ana Luiza , Viana Adriano Roessler
Published: August 2024

Submarine conduits are features responsible for transporting clastic debris from continents to the deep ocean. While the architecture of conduits has been extensively studied, the process of their inception remains unclear. This study highlights the possibility that some conduits are initiated by depositional processes involving turbidity currents. Here, we present the results of eight experiments where gravity currents were allowed to develop their own pathways. The simulation tank represented natural scales of continental shelves, slopes, and basins. The initial experiments involved sediment-laden flows with low density (1–10% in volume). In first experiment runs (Series I), sediment deposition occurred primarily on the shelf and slope, resulting in an asymmetric transverse profile. This asymmetry facilitated subsequent conservative currents (1034 to 1070 kg/m3 due to salt dissolution) flowing alongside during the second series, resulting in the formation of a constructive submarine conduit. This feature is analogous to gully formations observed in various locations. This study correlates these findings with gully-like features and proposes a model where non-confined density flows can evolve into confined flows through the construction of asymmetric topography. An evolutionary model is proposed to explain the mechanism, which potentially elucidates the formation of many submarine conduits.
Kinematic Stability Analysis of Anchor Cable Structures in Submerged Floating Tunnel under Combined Parametric–Vortex Excitation
Authors: Xiong Jiaming , Sang Song , Du Youwei , Gan Chaojie , Zhang Ao , Liu Fugang
Published: August 2024

The submerged floating tunnel is a marine transportation infrastructure that links two shorelines. The tunnel tube body’s buoyancy exceeds gravity, with anchoring ensuring equilibrium. Anchoring reliability is crucial. This study presents a three-way coupled kinematic model for the mooring structure, formulated on Hamilton’s principle and Kirchhoff’s assumption. It explores the impact of the tube body’s buoyancy-to-weight ratio and the sea current’s angle of incidence on mooring motion response. By solving the motion analysis model, Hill’s equation system is derived to assess the parameter instability of the anchor cable structure. The coefficient of excitation instability intervals for the submerged floating tunnel is determined and validated. The findings indicate the following: (1) Increasing the float-weight ratio reduces displacement response amplitudes in all directions, bringing downstream and transverse currents closer to their initial positions; (2) Changes in current direction angles result in decreased downstream excitation strength and increased transverse displacement response with the same excitation direction; (3) The instability interval visualization effectively predicts anchor cable structure instability under parametric excitation. Structures within the instability region are deemed unstable, while those outside are considered stable.
Response of a Coral Reef Sand Foundation Densified through the Dynamic Compaction Method
Authors: Gu Linlin , Yang Weihao , Wang Zhen , Wang Jianping , Ye Guanlin
Published: August 2024

Dynamic compaction is a method of ground reinforcement that uses the huge impact energy of a free-falling hammer to compact the soil. This study presents a DC method for strengthening coral reef foundations in the reclamation area of remote sea islands. Pilot tests were performed to obtain the design parameters before official DC operation. The standard penetration test (SPT), shallow plate-load test (PLT), and deformation investigation were conducted in two improvement regions (A1 and A2) with varying tamping energies. During the deformation test, the depth of the tamping crater for the first two points’ tamping and the third full tamping was observed at two distinct sites. The allowable ground bearing capacity at two disparate field sites was at least 360 kPa. The reinforcement depths were 3.5 and 3.2 m in the A1 and A2 zones, respectively. The DC process was numerically analyzed by the two-dimensional particle flow code, PFC2D. It indicated that the reinforcement effect and effective reinforcement depth were consistent with the field data. The coral sand particles at the bottom of the crater were primarily broken down in the initial stage, and the particle-crushing zone gradually developed toward both sides of the crater. The force chain developed similarly at the three tamping energies (800, 1500, and 2000 kJ), and the impact stress wave propagated along the sand particles primarily in the vertical direction.
Metagenomic Analysis of Seasonal Variations in Viral Dynamics and Diversity in Seawater of Jeju Island, Republic of Korea
Authors: Hwang Jinik , Oh Eun Gyoung , Jin Youngguk
Published: August 2024

Jeju, the largest island in Korea, is the most economically important in terms of marine aquaculture. We investigated the marine viral composition adjacent to Jeju Island over four seasons in 2022 and sequenced DNA libraries extracted from samples in March, June, September, and December using Illumina HiSeq 2000. We obtained 212,402, 186,542, 235,441, and 224,513 contigs from the four-season samples, respectively. Among the identified metagenomes, bacteriophages were dominant in all the samples. Bacillus phage G was the dominant species in March and June, whereas Pelagibacter phage HTVC 008M was the dominant species in September and December. Additionally, the number of viruses that infected algal hosts was higher in December than in other seasons. Marine viruses appeared in all seasons and infected marine vertebrates such as fish. Functional analysis using MG-RAST revealed that cell wall- and capsule-related metabolism groups were activated in March and June, whereas virulence-, disease-, and defense-related metabolism groups were activated in September and December. Conclusively, this study revealed seasonal changes in marine viral communities in the sea adjacent to Jeju Island. Our data will be useful in identifying emerging marine viral pathogens and for further community studies on marine organisms.
Study on Strain Field Reconstruction Method of Long-Span Hull Box Girder Based on iFEM
Authors: Chen Guocai , Wang Xueliang , Zhao Nan , Jiang Zhentao , Li Fei , Chen Haozheng , Wei Pengyu , Zhang Tao
Published: August 2024

The box girder’s condition significantly impacts the safety and overall performance of the entire ship because it is the primary stress component of the hull construction. This work used experimental research on the long-span hull box girder based on IFEM (Inverse Finite Element Method) technology to ensure the structural safety of the hull box girder. Due to the limitations of conventional experiments in this technical field, such as their reliance on finite element data and lack of input from physical tests, numerous research methods combining the strain sensing data from physical tests with the strain data from virtual sensors were conducted. The strain fields of the top plate, side plate, and bottom plate were each reconstructed in turn, and the verifier measuring points in the physical model test were used to assess the accuracy of the reconstruction results. The findings demonstrate that the top plate, side plate, and bottom plate reconstructions had relative errors of 0.24–7.86%, 0.75–8.13%, and 3.31–2.52%, respectively. This enables the reconstruction of the strain field of the long-span hull box girder using physical test data and promotes the use of iFEM technology in the field of structural health monitoring of large marine structures.
A Fusarium verticillioides MAT1-2 Strain near Isogenic to the Sequenced FGSC7600 Strain for Producing Homozygous Multigene Mutants
Authors: Gold Scott E. , Brown Daren W. , Williams Felicia N. , Nadon Brian D. , Vo Vivian T. , Miller Christine E.
Published: August 2024

Fungal genetic systems ideally combine molecular tools for genome manipulation and a sexual reproduction system to create an informative assortment of combinations of genomic modifications. When employing the sexual cycle to generate multi-mutants, the background genotype variations in the parents may result in progeny phenotypic variation obscuring the effects of combined mutations. Here, to mitigate this variation in Fusarium verticillioides, we generated a MAT1-2 strain that was near isogenic to the sequenced wild-type MAT1-1 strain, FGSC7600. This was accomplished by crossing FGSC7600 with the divergent wild-type MAT1-2 strain FGSC7603 followed by six sequential backcrosses (e.g., six generations) of MAT1-2 progeny to FGSC7600. We sequenced each generation and mapped recombination events. The parental cross involved twenty-six crossovers on nine of the eleven chromosomes. The dispensable chromosome 12, found in FGSC7603 but lacking in FGSC7600, was not present in the progeny post generation five. Inheritance of complete chromosomes without crossover was frequently observed. A deletion of approximately 140 kilobases, containing 54 predicted genes on chromosome 4, occurred in generation 4 and was retained in generation 5 indicating that these genes are dispensable for growth and both asexual and sexual reproduction. The final MAT1-2 strain TMRU10/35 is about 93% identical to FGSC7600. TMRU10/35 is available from the Fungal Genetics Stock Center as FGSC27326 and from the ARS Culture Collection as NRRL64809.
Profiling of the Citrus Leaf Endophytic Mycobiota Reveals Abundant Pathogen-Related Fungal Groups
Authors: Huang Feng , Ling Jinfeng , Cui Yiping , Guo Bin , Song Xiaobing
Published: August 2024

Plant endophytic microbial communities consist of many latent plant pathogens and, also, many pathogen-related species with reduced virulence. Though with a long history of co-evolution, the diversity and composition of the endophytic mycobiota, especially the pathogen-related fungal groups, has been under-investigated in Citrus (C.). Based on the amplicon sequencing of fungal internal transcribed spacer (ITS), the leaf endophytic mycobiota were profiled on citrus varieties from different citrus-producing regions. The pomelo variety shared significantly distinctive leaf mycobiota when compared to the mandarin and sweet orange; these conform to their host genetic relationships. In addition, a data set of 241 citrus-related fungi, including 171 (71%) pathogens and potential pathogens, was summarized from previous studies. Under the criteria of local BLAST (covered ITS nucleotide ≥ 150 bp, sequence identity ≥ 99%), a total of 935 fungal operational taxonomic units (OTUs) were assigned to 62 pathogen-related fungal groups, representing 14.9% of the relative abundance in the whole community. Of which, the top groups consisted of Colletotrichum gloeosporioides (mean relative abundance, 4.3%), Co. citricola and Co. karstii (2.7%), Zasmidium citri-griseum (2.4%), and Z. fructigenum (1.4%). At the genus level, the ratio of the pathogen-related fungal groups in 64% of fungal genera (16 out of 25) exceeded 50%, which are the solely or mainly occurring fungi of their genus in citrus. Our study suggests that the leaf endophytic compartment may be an important place for the growth of latent pathogens.
A New Overview of Sex Bias in Fungal Infections
Authors: Rao Hari H. , McClelland Erin E.
Published: August 2024

Fungal infections often disproportionately affect males over females. Since the NIH mandated in 2016 that researchers test their hypotheses in both biological sexes, numerous other fungal infections/colonizations have been found to exhibit sex-specific patterns. These patterns have been observed in various species, including mice, drosophila, cats, and bats, suggesting significant implications for understanding these diseases and developing treatments. Despite the recognition of this sex bias, primary research explaining its underlying causes or mechanisms remains limited. Current evidence suggests that potential causes might be linked to sex hormones, genetic expression, and evolutionary behaviors. This review consolidates recent data on sex bias in fungal infections or colonizations among different species and proposes future research directions to address existing gaps. Thus, this review advances the comprehension of the intricate relationships between biological sex, fungal infections, and broader health implications.
ESG Performance and Systemic Risk Nexus: Role of Firm-Specific Factors in Indian Companies
Authors: Gidage Mithilesh , Bhide Shilpa , Pahurkar Rajesh , Kolte Ashutosh
Published: August 2024

This study investigates the ESG performance–systemic risk (SR) nexus among Indian companies. Using the beta coefficient from the Capital Asset Pricing Model (CAPM) and statistical analysis, it explores how ESG performance affects SR. The findings reveal that firms with higher ESG scores have lower SR sensitivity. Notably, there is a significant difference in risk sensitivity between high- and low-ESG-rated companies, with ESG effects being less pronounced in high-cap firms compared to low-cap firms. Conversely, large firms, older firms, and those with lower borrowing costs show a diminished effect of ESG ratings on their SR sensitivity. These results underscore the importance of firm-specific characteristics in determining the efficacy of ESG strategies in risk mitigation. This study reveals that ESG performance reduces SR, with market valuation affecting this relationship.
The NGDOs Efficiency: A PROMETHEE Approach
Authors: Álvarez-Otero Susana , Álvarez-Valle Emma
Published: August 2024

The current economic and political crisis has brought about a change in the environment in which non-governmental development organisations (NGDOs) have traditionally operated. This change can be summed up as a reduction in the funds they receive and an increase in the population they must serve. The need then arises to have mechanisms that allow an analysis of the good work performed by the NGDOs. Knowing the efficiency of the NGDOs in the management of their previous projects can contribute towards improving their future achievements. The aim of this research is to establish some objective indicators that allow an evaluation of the efficiency of these organisations. Firstly, a detailed analysis of the regulation of the three agencies is conducted (Spanish-AECID, European-EuropeAid, and American-USAID). This allows us to synthesise the indicators of good performance of the NGDO based on the study of the eligibility criteria of public donors. The research concludes with the study of the efficiency following the Promethee Approach. Our results reveal that 44.6% of the NGDOs (33 out of the 74 studied) operate inefficiently, compared to 29.7%, which are efficient.