bluuebunny/crossref_metadata_2025 huggingface dataset:
Dietary combinations of L-threonine and encapsulated source of butyric acid (ButiPEARL) modulate growth, some physiological and biochemical parameters, histomorphometry of the intestine, and economic indices of Nile tilapia (Oreochromis niloticus) fingerlings
Authors: Youssuf Hadeer A. , Shehab Ahmed , Hamed Amira M. Abd-El , Raslan Walaa S. , Magdy Yasmin , Mohamed Mona Gamel , kadah Amgad , Matter Aya F.
Published: July 2024

Background Various immunostimulants have been used as additives in fish feed because they enhance growth and immunity. The current work examined the impact of dietary L-threonine and an encapsulated form of butyric acid (ButiPEARL) on various aspects of Nile tilapia, Oreochromis niloticus (O. niloticus), including growth performance and immune response.
Materials and methods: A total of six experimental fish groups (n = 80) were utilized. The fish in the control group (G1) were fed a basal diet, while those in the other groups were fed experimental diets. The feeding was done twice daily for 42 days, with the food given being 5% of the fish's body weight. The water parameters were maintained at suitable levels.
Results The supplementation of these feed additives, particularly the group of fish fed a diet containing 0.3g/kg of encapsulated butyric acid (ButiPEARL) mixed with 0.48g/kg of L-threonine, exhibited the highest values throughout the experiment. This supplementation significantly enhanced growth performance indicators such as length gain, weight gain, weight gain rate (WGR), specific growth rate (SGR), and feed conversion ratio (FCR). Furthermore, it positively influenced immunological parameters (IgM, albumin, total protein in serum, and nitrous oxide in liver tissue), liver enzymes (ALT, AST in serum), antioxidants (superoxide dismutase and catalase, SDA) and malondialdehyde, MDA in the liver), biochemical assays (plasma glucose concentrations), and digestive enzymes (lipase and amylase) in plasma. Regarding fish farm profitability, a higher net profit can be achieved by maximizing returns while minimizing costs. The histology and scanning electron microscopy (SEM) analysis of the O. niloticus intestines revealed significant improvements in the length and width of the intestinal villi.
Conclusion The inclusion of L-threonine (0.48g/kg) and encapsulated butyric acid (ButiPEARL) (0.3g/kg) in fish diets can serve as safe, natural, and cost-effective feed additives. A combined inclusion level of these additives is recommended to enhance growth, boost immunity, support liver function, and promote intestinal development.
Mitigating Spatial Hallucination in Large Language Models for Path Planning via Prompt Engineering
Authors: Zhang Hongjie , Deng Hourui , Ou Jie , Feng Chaosheng
Published: July 2024

Spatial reasoning in Large Language Models (LLMs) serves as a foundation for embodied intelligence. However, even in simple maze environments, LLMs often struggle to plan correct paths due to hallucination issues. To address this, we propose S2ERS, an LLM-based technique that integrates entity and relation extraction with the on-policy reinforcement learning algorithm Sarsa for optimal path planning. We introduce three key improvements: 1) To tackle the hallucination of spatial, we extract a graph structure of entities and relations from the text-based maze description, aiding LLMs in accurately comprehending spatial relationships. 2) To prevent LLMs from getting trapped in dead ends due to context inconsistency hallucination by long-term reasoning, we insert the state-action value function Q into the prompts, guiding the LLM's path planning. 3) To reduce the token consumption of LLMs, we utilize multi-step reasoning, dynamically inserting local Q-tables into the prompt to assist the LLM in outputting multiple steps of actions at once. Our comprehensive experimental evaluation, conducted using ChatGPT 3.5 and ERNIE-Bot 4.0, demonstrates that S2ERS significantly mitigates the spatial hallucination issues in LLMs, and improves the success rate and optimal rate by approximately 29% and 19%, respectively, in comparison to the SOTA CoT methods.
Designing a plasma device and its application on plant medium
Authors: Rezabeygi Seddigheh , Ahmadi Mohamad Taghi , Rahmani Meysam , Kheiralipour Kamran
Published: July 2024

In this research,a corona plasma discharge device is designed and used on the plant medium in ambient air. Furthermore, the kinetic theory of plasma is utilized and its energy and drift velocity impact on the plant atmosphere analytically is investigated in the modeling section. The effect of cyclotronic frequency, and plasma particle drift velocity on particle energy and its distribution during the collision with the plant surface as an essential factor for the germination process is analyzed. This transfer of energy appears as the kinetic energy of the particles and can be explained in the form of the required energyto prepare an appropriate growth atmosphere for the seeds. The higher plasma particle drift velocity leads to higher energy distribution on the seed surface. The effect of low-temperature pulsed plasma application period and direction on the germination and growth rate of seeds are investigated. Dry chickpea seeds are taken into consideration to be the outturn of the same farm and stored in the same barn and condition. The seeds are exposed to plasma at time intervals of 3,7, and 12 minutes. The results showthat the seeds with 7 minutes of plasma treatment had better growth and rejuvenation compared to the control sample and other samples. The 3-minute plasma application to samples decreased the germination and growth. Additionallyseeds are treated by plasma beam from the germination site (embryo),the back of the embryo, and the cotyledons. The results indicate that applying plasma to the embryo enhances the growth of the chickpea seeds after 30 days of observation.
Investigation of Imbibition Front and Phase Distribution in Shale based on LBM
Authors: Lu Li , Lu Xiaobing , Zhang Xuhui , Huang Yadong , Liu Kuo
Published: July 2024

In order to study the development of imbibition such as the imbibition front and phase distribution in shale, Lattice Boltzmann Method(LBM) is used to study the imbibition processes in the pore-throat network of shale. Through dimensional analysis, four dimensionless parameters affecting the imbibition process were determined. A color gradient model of LBM was used in computation based on a real core pore size distribution. The numerical results show that the four factors have great effects on imbibition. The effect of each factor is not monotonous. The imbibition process is the comprehensive effect of all factors. The imbibition front becomes more and more non-uniform with time in a heterogeneous pore-throat network. Some non-wetting phase (oil here) cannot be displaced out. the displacement efficiency and velocity do not change monotonously with any factor. The development of the average imbibition length with time is not smooth and not linear in a heterogeneous pore-throat network. Two fitting relations between the four dimensionless parameters and the imbibition velocity and efficiency are obtained, respectively.
Research on Vibration Control of Base Structure with Composite Variable-thickness Wave Absorbing Damping Plate
Authors: Zhou Yi , Liu Wenxi
Published: July 2024

The composite variable-thickness wave absorbing damping plate is used to realize the acoustic wave aggregation and vibration energy consumption by adjusting the impedance of the structure. The overall finite element model is constructed by embedding two variable-thickness plates in the middle of a rectangular plate simply supported at both ends. The finite element method is used to calculate the vibration response of the structure and compare the calculated values with the experimental values in order to verify the correctness of the numerical simulation results, and the vibration spectrum peaks of the base panel are taken as the control target, so that the intrinsic frequencies of the monolithic and composite variable-thickness wave absorbing damping plates can be designed by adjusting the material and structural parameters. The variable-thickness plate is fixed to the position with the largest vibration amplitude on the target base panel to realize the coupling resonance with the vibration source, thus absorbing and dissipating the bending vibration energy. In order to control the calculation scale, the area element is used instead of the volume element, and the thickness of variable-thickness plate is assigned by the function to ensure the continuous change of the plate thickness, and the results of the study show that: the numerical simulation model constructed by the above method can greatly improve the calculation efficiency. In the frequency range of 5 ~ 600 Hz, the use of the above composite variable-thickness wave absorbing damping plate (based on the vibration spectrum peak structure) and the connection method can significantly reduce the vibration amplitude of the base panel at the spectrum peak without affecting the strength and weight of the target structure.
WITHDRAWN: An eco-extraction procedure for solvent free extraction of plant phenolics using microwave hydro diffusion and gravity (MHG) model
Authors: Sinha Anjli , Mukherjee Souvik , Chouhan Kavi Bhushan Singh , Mahato Kashinath , Khan Altamash , Dwivedi Apoorva , Pal Riya , Patra Arjun , Mandal Vivekananda
Published: July 2024

The current work exemplifies a strategic implementation of blended mode microwaving in the MHG model for the solvent-free extraction of phenolics from the leaves of the plant Medicago polymorpha. Blended mode comprises of a mix of 510W microwave power level for 5 min, followed by 340W exposure for 5 min and then finally prolonged exposure of 170W in cycles of 5 min each till the end point is reached. The extraction performance was assessed by the total phenolic and flavonoid contents which was found to be 65.1 and 66.7 mg GAE/QE per g of dried extract respectively, for the extract obtained from MHG (blended mode). Soxhlet extract on the other hand could produce 45.4 and 52.4 mg GAE/QE per g of dried extract. In total 18 phenolic principles were detected out of which 09 compounds showed more than 50% depletion in the extract obtained from Soxhlet. In addition to this extract obtained from MHG showed better stability as only 18.9% degradation was reported in a span of 60 days when compared to 64.1% for the Soxhlet extract for the same length of time. Improved thermal stability and antioxidant activity were the other add on features for the extract obtained through MHG (blended mode). Such technologies embraces environment and progresses sustainably.
A values-driven academic affiliation between a public medical school and a private healthcare provider: exploring the perceptions of key opinion leaders
Authors: Du Preez Leon , Otaki Farah , Clemens Timo , Al-Hammadi Suleiman , Stanley Adrian , Ho Samuel B. , Kilian Paddy , Loubser Pietie , Bayoumi Riad , Ezimokhai Mutairu , Bedford Barry , Fathey Tarek , AlGurg Reem , Suwaidi Hanan Al , Sharif Amer A. , Alsheikh-Ali Alawi A.
Published: July 2024

In an Academic Health System model where university and clinical care institutions are separate entities, robust agreements are needed for effective working relationships among the involved institutions. There is paucity in the literature around reports of such affiliations, especially those relating to public private partnerships. Accordingly, the overall purpose of this study is to explore the perception of key opinion leaders about the development of a values-driven affiliation between a public medical school and a private healthcare provider in an Academic Health System in Dubai, United Arab Emirates. The process of developing the respective affiliation was based on the principles of action research. It involved ongoing cycles of planning, acting, observing, and reflecting. This study relied on a qualitative phenomenological research design, where 18 primary stakeholders, who played an active role in making the affiliation, were given the option of providing their feedback either in writing, using a tailor-made questionnaire, or in the form of a semi-structured interview. Constructivist epistemology constituted the basis of the entailed interpretive qualitative analysis, which followed the six-step analysis approach initially introduced by Braun and Clarke (2006). The qualitative analysis led, as per this study’s conceptual framework: ‘Public Private Affiliation Journey’, to two interconnected themes, namely: Key Milestones and Driving Forces. Within Key Milestones, seven sequential categories were identified: Observing a triggering need, Finding a good match, Seizing the opportunity, Arriving at a common ground, Looking ahead, Venturing for the right reasons, and Reaping the benefits. Within the second theme: Driving Forces, the following three categories were identified: Aspiring for success, Leveraging human qualities, and Doing things the right way. This study showed that there is a latent potential in forming public private partnerships that can enable the formation and development of Academic Health Systems. It also showcased how the guidelines of action research can be set as the basis of the process of partnership formation, and how following those guidelines in such an endeavor maximizes value for all. Lastly, this study introduced the ‘Public Private Affiliation Journey’ conceptual framework, which can be deployed in ‘federated’ Academic Health Systems worldwide to increase the chances of success of public private partnerships and to maximize the value attained through them.
Comprehensive representation of health-related phenotypes in one million dogs using topic modelling of electronic health records
Authors: Noble Peter-John Mäntylä , Farrell Sean Oliver , Al-Moubayed Noura , Radford Alan David
Published: July 2024

Historically, veterinary studies screening for breed, age and sex predisposition to disease have relied on collating small-scale studies of clinical datasets. The availability of larger datasets through groups such as the Small Animal Veterinary Surveillance Network (SAVSNET) promise access to information regarding wide range of clinical presentations at scale, however, methodological limitations surrounding the extraction of specific disease information or screening for disease predispositions result in a substantial reduction in the number of animals studied. These studies often address very focused hypotheses - only leveraging a small fraction of the intrinsic value of the data at any one time. Here, we implemented an unsupervised machine learning methodology, creating a representation of a large volume of clinical notes collected by SAVSNET from veterinary practices across the UK. We capture breed, age and sex predisposition and offer statistical and temporal possibilities across various clinically important presentations. We utilise BERTopic, a topic-modelling tool based on Bidirectional Encoder Representations using Transformers (BERT) architecture, which surfaces known phenotypes, such as breed predispositions to hypoadrenocorticism, diabetes mellitus and mitral valve disease, and potential novel patterns of disease phenotypes. This scalable and granular modelling technique facilitates the rapid interrogation of large clinical datasets, enabling the identification of broad phenotypic diversity within the population and the early detection of temporal changes indicative of emerging infectious or environmental diseases.
Advancing Blockchain-Enabled InterPlanetary File System with Substrate for Distributed Data Storage
Authors: Nyirenda Clement , Nododile Thandile
Published: July 2024

In addressing the significant challenges caused by the expansion of data storage needs in blockchain systems, this paper explores the integration of the InterPlanetary File System (IPFS) with Substrate-based blockchain. By leveraging IPFS for off-chain storage and Substrate for on-chain operations, this system addresses the key challenges such as bloated storage, inefficiency, and accessibility while preserving data distribution and privacy. Through a comparative analysis with an Ethereum-based system, this study reveals significant advantages of the
Substrate-IPFS solution. There is a significant reduction in data storage size and faster block confirmation times, leading to potentially lower transaction costs. The proposed approach enhances data privacy through the use of the Blake2 hashing algorithm. Overall, this research showcases the potential of Substrate-IPFS integration in overcoming the limitations of traditional blockchain storage approaches. Further exploration into the storage cost optimisation within the Substrate framework and additional functionalities using modular pallets could pave the way for significant advancements in the distributed data storage.
BRIDGING PROFESSIONAL DEVELOPMENT WITH CAREER GUIDANCE IN EFL ONLINE COURSE
Authors: Liashenko Iryna , Carroll Stuart
Published: July 2024

The topic of professional development with the teachers has been an integrative part of professional competence shaping, meaning the multifaceted and complex nature of this essence in forms, stages, stakeholders, methods, and many more. This article aims to highlight the shared insights about the online course on professional development, designed for secondary school teachers of English from Ukrainian places in the time of war as a career guidance course and spot the connections between online professional courses and willingness to promote the university to high school students for enrolling. The research was conducted grounding in the continuous flow of research about the teaching and learning process in the time of COVID-19 when the education system urged to switch to the online or blended mode, the period of trial and error in conforming to the demanding requirements for successful communication and in substituting the live communication. The authors claim to enlighten the perceptions of the participants of the course to reveal the ways of improving the course for further usage. The article shares the quantitative and qualitative data to reflect the degree of the teachers’ perspective.
PRAGMALINGUAL MEANS OF INFLUENCE ON THE AUDIENCE IN MASS MEDIA
Authors: Medvid Olena , Doinikov Kyrylo , Azimova Olena
Published: July 2024

The purpose of the research is to reveal the synergistic relationship between methods of psychological manipulation and media texts of socio-political discourse in well-known English-language media resources. The possibility of intensifying the influence of media texts due to the use of pragmalinguistic means at different language levels (from lexico-semantic to morpho-syntactic) has been studied. As a result of the analysis of a large number of academic works on the problems under investigation, it was found that the function of influencing the recipient of information and even manipulating public opinion is the essential function of a media text, and using pragmalinguistic means is one of the most powerful tools for implementing this function. The empirical part of the work was carried out in the translation center LinguoStar of Sumy State University, which made it possible to fullfill a quantitative analysis of translation transformations on the way to the equivalent transfer of various speech means of manipulative influence in English-language media texts of socio-political discourse, which outlines the broad equivalent possibilities of the Ukrainian language in the translation process. The practical significance of this study can be used to improve the qualifications of journalists and translators in the field of media linguistics.
LINGUOSYNERGETIC VECTOR OF STUDYING CONTEMPORARY UKRAINIAN DISCOURSE (ON THE MATERIAL OF “VOROSHILOGRAD” BY SERHIY ZHADAN)
Authors: Chernysh Anna
Published: July 2024

This study delves into the linguosynergetic approach to analyzing language within contemporary Ukrainian discourse, specifically through the lens of Serhiy Zhadan’s novel “Voroshilovgrad”. In this context, language is perceived as a complex adaptive system, characterized by nonlinear interactions and self-organization. By employing principles of linguosynergetics, such as open systems, non-linearity, self-organization, and bifurcations, the research uncovers the mechanisms through which language evolves in response to varying socio-cultural environments. The novel “Voroshilovgrad” serves as a quintessential example of this dynamic process. Through its narrative, the novel captures the essence of a society in flux, where linguistic elements are not merely passive conveyors of meaning but active participants in the creation of rich and multifaceted literary concepts. The concepts exemplify how language and culture are intertwined, each influencing and shaping the other in a continuous feedback loop. By integrating the principles of linguosynergetics, this study not only enhances our understanding of Zhadan’s work but also contributes to the broader field of linguistics and literary studies. It showcases the relevance of linguosynergetics in analyzing literary texts, particularly in contexts marked by rapid social and cultural transformations. Through this approach, the research underscores the intricate relationship between language and culture, affirming the significance of linguistic studies in interpreting and understanding the evolving narratives of post-Soviet societies. In sum, this study offers valuable insights into the dynamic processes through which language and culture interact, evolve, and coalesce to form the rich tapestry of contemporary Ukrainian discourse.
PROBLEMS OF ECOLOGIZATION OF THE MODERN UKRAINIAN LANGUAGE
Authors: Geichenko Katerina , Dochinets Dmytro
Published: July 2024

It is always important to talk about the purity of language, as language is one of the main means of communication and expression. Here are some reasons why it is important today: a). Ensuring clarity: The use of correct language facilitates understanding between language promotes understanding between interlocutors. Incorrect use of words, grammatical structures or pronunciation can lead to misunderstandings. b). Professional credibility: In many areas of life, correct speech can affect the first impression and the level of professional credibility. Competent language shows the culture of the interlocutor and their level of education. c). Preservation of cultural heritage: Language is not only a means of communication, but also a part of cultural heritage. Compliance with the rules of the language contributes to preservation and development of language culture. d). Effective communication: Correct speech helps you to express your thoughts, ideas and feelings effectively. People with right speech can express yourself more accurately and clearly. These topics can occur in a variety of contexts, from academic discussions to practical measures to improve speech culture. The authors of this article consider several factors that may affect the ability of Ukrainians to speak the correct literary language: 1). The influence of dialects and language variants: Ukraine has many regional dialects and language variants that can affect the way words are pronounced, word usage and grammar. 2). Language contact: The richness of language contact in Ukraine can lead to the borrowing of words, phrases and grammatical constructions that do not always meet the standards of the literary Ukrainian language. 3). Lack of language education: Lack of opportunities to receive quality language education or insufficient attention to language literacy in the programs can affect the level of language skills. 4). Socio-cultural context: Socio-cultural factors such as social status, education, media, and the influence of the Internet can influence the language behavior and word use of Ukrainians. 5). Lack of motivation: Lack of motivation to learn and use the correct language can be an obstacle for Ukrainians. 6). Political and historical context: Historical events and political processes also influence Ukrainians' language choices and speech practices. As a result of these factors, Ukrainians may have different levels of language literacy and use of the literary language. However, the interest in improving language skills and proper language education can help to improve this situation. Thus, it is important to talk about language purity today in order to maintain quality communication, preserve cultural heritage and increase the level of professional trust.
STRATEGIES FOR LEARNING PRONUNCIATION ONLINE: SERBIAN EFL LEARNERS’ PERSPECTIVE
Authors: Danica Jerotijević-Tišma
Published: July 2024

Digital tools and online teaching platforms offer vast opportunities for language learning, yet, even though many indeed focus on pronunciation practice only, there seems to be a noticeable lack of research supporting their effectiveness. The current paper investigates Serbian EFL learners' views on the possible strategies employed for successful online pronunciation practice. A total of 105 tertiary-level English-major students at the Faculty of Philology and Arts, University of Kragujevac, Serbia, participated in the pre-designed survey concerning online learning strategies with a particular focus on pronunciation practice. The primary instrument was a questionnaire consisting of three parts: part one concerned with the demographic information on the sample, part two containing statements related to offline pronunciation learning strategies and part three focusing on online pronunciation learning strategies. Based on the results, dominant strategies for pronunciation practice in face-to-face classrooms are directed toward improving individual sounds and intonation. Thus, both segmental and suprasegmental features are incorporated in the students’ pronunciation instruction. When it comes to the pronunciation learning strategies online, students seem to prefer cognitive and metacognitive strategies, while social strategies seem to lack popularity among Serbian EFL students. In general, a relatively even distribution of responses was noted for both ends of the scale for the majority of proposed strategies which is explained by the specific professional orientation of the respondents. The findings underscore important pedagogical implications not only for learning English online, but for the improvement of pronunciation practice in the Serbian EFL context in general.
SPECIFICS AND CHALLENGES OF TRANSLATING GERMAN LEGAL CONTRACTS
Authors: Klymenko Alla
Published: July 2024

The main aim of this research is to explore the theoretical and practical aspects of translating German legal contracts to identify theoretical and practical problems arising in this process, as well as to analyze the peculiarities of German legal documents. Taken together, theoretical and practical problems in translating legal texts pose a significant challenge for translators and require a deep understanding not only of language but also of legal terminology, cultural nuances, and contextual differences between legal systems. Translating legal texts is often associated with great responsibility, as even the slightest inaccuracy or misunderstanding can have serious consequences for the parties entering into agreements or using legal documents. This places upon the translator the task not only of conveying linguistic content but also of preserving the accuracy and legal correctness of the translation. Developing recommendations for improving the quality of translation of German legal contracts and adapting them to the requirements of international standards is an important task of the research. This may include the development of specialized translation techniques, enhancing translators' qualifications, and establishing quality standards in this field.
Study on the evolution of dissolved organic matter in the underground storage of mine water
Authors: Zhang Xiyu , Dong Shuning , Liang Jidong , Guo Xiaoming , Huang Lingyun
Published: July 2024

The water–rock interactions significantly affect the dissolution and release of dissolved organic matter (DOM) during the reinjection of mine water into the underground reservoir. In this study, the surface characteristics and chemical composition of the natural medium from the open-pit coal mine were characterized. The waste consists mainly of quartz-dominated sandstone (43.64%) and mudstone dominated by sanidine (76.36%). During the 35-day experiment, two protein-like, one humus-like, and one fulvic acid-like substances were identified by PARAFAC. It was observed that the type of aqueous medium significantly affected the variational trend of DOM. Compared to the artificial medium, the fluorescence intensity of waste materials in the waste dump increased significantly during the reinjection process. Therefore, a positive correlation was observed between the fraction of mudstone in the aqueous medium and the DOM composition, mainly due to the dissolution of polycyclic aromatic hydrocarbon substances from the mudstone. The results revealed that the natural water storage medium had a certain water storage feasibility when compared with the expensive artificial medium. However, the fraction of mudstone in the water storage medium should be controlled to minimize the release of organic matter into the environment.
Manga na Paraíba: Uma Análise Temporal (2002-2022) da Dinâmica da Produção
Authors: Santos João Paulo de Oliveira , Bulhões Luis Eugênio Lessa , Melo José Affonso Batinga de , Lima Denilson da Silva de , Santos Alex da Silva , Silva João Henrique Barbosa da , Silva Luiz Daniel Rodrigues da , Pereira Daniel Duarte , Sousa Valéria Fernandes de Oliveira , Nascimento Izaias Romário Soares do
Published: July 2024

Na Paraíba, a produção de frutas vem aumentando em área plantada e na diversidade de espécies utilizadas, entre elas, a manga, que possui importância expressiva em diversas regiões do estado, sendo produzida, assim como outras culturas frutíferas, predominantemente por agricultores familiares. Nesse sentido, objetivou-se com este estudo avaliar a dinâmica da produção de manga no estado da Paraíba, utilizando-se como recorte temporal o período de 2002 a 2022. Utilizou-se dados da Pesquisa Agrícola Municipal do IBGE (2002-2022) para avaliar seis variáveis relacionadas à produção de manga. Utilizou-se ainda uma Análise de Componentes Principais (ACP) para compreender as inter-relações entre as variáveis ao longo do tempo. A produção de manga na Paraíba passou por uma considerável retração durante o período de 2002 a 2022. Foram observadas reduções na área destinada à colheita e área colhida, assim como na quantidade produzida e na produtividade. A ACP evidenciou a forte associação entre quantidade produzida, área cultivada e produtividade, em contraste com o valor da produção.
Cancer Antibody Engineering: Comparison of Mammalian, Yeast, Bacterial, Plants, Cell-free and Hybridoma Expression Systems
Authors: Ng Ming Guan , Tan Hui Ying , Ng Pei Ying , Koh Rhun Yian , Voon Kenny Gah Leong , Chye Soi Moi
Published: July 2024

Background:

Cancer is a significant issue worldwide. Generally, commercially
available treatments, such as surgery, radiotherapy, and chemotherapy, are associated with undesirable
complications. Hence, immunotherapy serves as a crucial alternative to those treatment
options.

Objective:

This modality is aimed to boost the immune system through the application of engineered
antibodies, which can be produced using recombinant DNA technology.

Results:

The discussion of the technologies leads to an introduction of the single-chain variable
fragment (scFv). Thereafter, the advantages, disadvantages, and challenges associated with different
expression systems, such as mammalian cells, yeast cells, bacterial cells, plant cells, and
phage display were discussed comprehensively.

Conclusion:

Furthermore, conventional approaches such as hybridoma and modern approaches
such as cell-free protein synthesis (CFPS) and simple colony assays are included. In short, this
article has compiled evidence relating to each display system and may serve as a reference for
those who aim to explore antibody engineering using one of the methods listed in this article.
Applicability of Salting-out Liquid-liquid Extraction for New Fluorimetric Quantification of Omadacycline in Pharmaceutical Formulations and Biological Samples
Authors: Alzahrani Eman , Abdel-Lateef Mohamed A. , Salman Baher I.
Published: July 2024

Objective:

A detectable innovative fluorimetric method was used to determine OMC in
human plasma matrices, pharmaceutical tablets, and vials with high recovery rates and without biological
interference.

Methods:

The fluorimetric technique was used based on the interaction between 4-chloro7-nitrobenzofurazan
(NBD-Cl) with a (2-ry amine group) in OMC with pH 8.0, which generates a fluorescent
compound measured at 530 nm (exci 470 nm) following a 10-minute heating step at 80 oC.
The plasma and milk samples were treated with ammonium sulfate as a salting-out procedure.

Results:

Omadacycline (OMC) was successfully determined in pharmaceuticals, plasma, and milk
samples with a linear range from 60.0 to 700.0 ng mL-1, with the lower limit of detection (LOD
5.18 ng mL-1) and limit of quantitation (LOQ 15.72 ng mL-1).

Conclusion:

This simple, reliable, and detectable fluorimetric method was successfully developed
to determine omadacycline in pharmaceutical tablets, plasma samples, and milk with high recovery
rates.
An Updated Review Summarizing the Anticancer Potential of Naringenin
Authors: Sharma Srishti , Mishra Anuja , Ramniwas Seema , Pandey Pratibha
Published: July 2024

One important phytochemical is naringenin, which belongs to the flavanone class of
polyphenols. It is found in citrus fruits, such as grapefruits, but it can also be found in tomatoes,
cherries, and other food-grade medicinal plants. Naringenin has a significant chemotherapeutic
promise, as several investigations have conclusively shown. Therefore, the goal of this review is
to synthesize the literature that has been done on naringenin as a possible anti-cancer agent and
clarify the mechanisms of action that have been described in treatment plans for different kinds
of cancer. In a variety of cancer cells, naringenin works by affecting several pathways associated
with cell cycle arrest, anti-metastasis, apoptosis, anti-angiogenesis, and DNA repair. It has
been shown to alter several molecular targets linked to the development of cancer, such as drug
transporters, transcription factors, reactive nitrogen species, reactive oxygen species, cellular
kinases, and inflammatory cytokines and regulators of the cell cycle. In summary, this research
provides significant insights into the potential of naringenin as a strong and prospective candidate
for use in medicines, nutraceuticals, functional foods, and dietary supplements to improve
the management of carcinoma.
Efficacy of Keystroke Dynamics-Based User Authentication in the Face of Language Complexity
Authors: Dutta Sandip , Roy Utpal , Roy Soumen
Published: July 2024

Introduction:

This study investigates the impact of language complexity on Keystroke
Dynamics (KD) and its implications for accurate KD-based user authentication system
performance in smartphones.

Method:

This research meticulously analyzes keystroke patterns using 160 volunteers, including
both frequently typed and infrequently typed texts. Our analysis of 12 anomaly detection
algorithms reveals that a simple text-based KD system consistently outperforms its complex
counterpart with superior Equal Error Rates (EERs).

Results:

As a result, the Scaled Manhattan anomaly detector achieves an EER of 2.48% for
simple text and an improvement over 2.98% for complex text. The incorporation of soft biometrics
further enhances algorithmic performance, emphasizing strategies to build resilience
into KD-based user authentication systems.

Conclusion:

Throughout this study, the importance of text complexity is emphasized, and innovative
pathways are introduced to strengthen KD-based user authentication paradigms.
Essential Oil: Its Chemistry, Biochemistry and Application
Authors: Agrawal Mohit , Rao Komal , Singhal Manmohan , Chaudhary Hema
Published: July 2024

Essential oils are secondary metabolites that are produced by a variety of
medicinal plants. These are mostly composed of a blend of terpenic hydrocarbons and
oxygenated derivatives like ketones, alcohols, epoxides, aldehydes, and esters. These
are insoluble in water but are soluble in ether, alcohol, and fixed oils. The majority of
these volatile oils are liquid and colourless at room temperature. The majority of the
components found in essential oils are from the terpene family and are concentrated in
the cell secretions of specific plants. The chemical makeup and positioning of
functional groups on molecules affect the mechanism of action of essential oils. When
it comes to their antibacterial activity, essential oils' chemical makeup influences how
they work. The content is about several essential oils, such as lavender oil, which has
antibacterial and antifungal properties due to its primary ingredients, linalool and βocimene. Both anti-inflammatory and antibacterial properties can be found in
eucalyptus oil, which contains the primary ingredients 1,8 cineole, cryptone, p-cymene,
and pinene. Sulphur molecules found in garlic essential oils are effective in preventing
cancer. In order to confirm the safety and effectiveness of essential oils, more clinical
trials are obligatory. Essential oils possess the ability to be employed as defensive as
well as therapeutic agents for a variety of ailments. 
ROTARY SOOT BLOWING TREATMENT INCREASES EFFECTIVENESS OF ECONOMIZER CAPACITY OF 58.5 TPH AT PT SBI INDONESIA
Authors: Harianto Agus , Aspiyansyah Aspiyansyah , Rahman Muhammad Muksin Galih
Published: July 2024

In an industrial era that increasingly prioritizes energy efficiency and environmental sustainability, optimizing the use of energy in the production process is crucial. One of the key aspects of achieving this goal is utilizing waste heat to improve the overall efficiency of the system. In this context, the use of economizers has become a major focus in the boiler industry. PT Surya Borneo Industri (SBI), as an industrial entity committed to energy efficiency and environmental sustainability, has adopted the latest technology in a bid to improve the performance of their boiler system. One of the latest innovations they have implemented is the use of rotary soot blowing, an automated device designed to clean the heat exchanger surfaces in the economizer. This study aims to determine the effectiveness value of the economizer before and after the rotary soot blowing treatment on the PT SBI boiler system. Through a series of field observations and data analysis, this research reveals the potential benefits of using rotary soot blowing in improving thermal efficiency, reducing energy losses, and contributing to the sustainability of industrial operations. The results obtained showed that the economizer effectiveness value before the rotary soot blowing treatment was 55, 54, 55, and 54%, and after the rotary soot blowing treatment, the effectiveness value increased to 59, 60, 61, and 60%. This is due to maintenance activities, namely cleaning dust or soot attached to the economizer pipes.
SUPERHYDROPHOBIC AND ANTIBACTERIAL COATINGS ON VARIOUS COTTON FABRICS USING ZNO AND AESO
Authors: Wijaya Hastono , Gapsari Femiana , Sulaiman Abdul M. , Harmayanti Afifah , Barasa Alvadro , Andrean Janu , Warman Sa Bashkaran Adi , Kriswardhana Willy , Naimah Azimatun
Published: July 2024

Superhydrophobic coatings on cotton utilized in medical applications like hospital gowns and bed linens to offer a protective barrier against fluids and bacteria. Masks were worn with different types of materials. In this study, various cotton employed ZnO and AESO to effectively decrease the surface energy of cotton fabric via a Schiff base reaction. This chemical transformation resulted in the formation of a textured surface structure that exhibited robust adhesion qualities. The study demonstrates that the superhydrophobic coating on silk fabric increases 153. 59%. The coating on silk provides a reference for fabric types with ZnO and AESO coatings.
EFFECT OF VARIATION OF MAGNETIC INDUCTION SOLENOID VALUES ON TENSILE AND IMPACT STRENGTH FOR WELDING BETWEEN LOW CARBON STEEL AND MEDIUM CARBON STEEL
Authors: Pribadi Aries Fajar , Alamsyah Fikrul Akbar , Hidayat Wahyu , Prayudi Makrusy Eko , Masykur M Alfin , Solihin Ihin , Raharjo Rudianto
Published: July 2024

The use of solenoid magnets in welding processes has attracted attention due to their potential to influence the properties of welded joints. This research investigates the effect of the size of the magnetic induction solenoid on the tensile strength and impact toughness of welds between mild steel and medium carbon steel. Welding experiments were carried out using various sizes of solenoid magnets (0; 1.71mT; 2.11mT; 2.31mT; 2.60mT), and the welding results were tested for tensile strength and impact toughness. The findings show that the size of the magnetic induction solenoid has a significant effect on the mechanical properties of the weld. The larger induction size in this study increased the tensile strength of the welded joint, namely 431.576 N/mm2 without induction and 533.33 N/mm2 with induction. Meanwhile, the impact toughness of welded joints also increases, namely 95.92N.m without treatment and 217.35N.m with induction.
DECREASING ELECTRICAL ENERGY COST AND INDIRECT CO2 EMISSIONS OF AN AIR CONDITIONING UNIT AFTER PREVENTIVE MAINTENANCE
Authors: Risonarta Victor Yuardi , Widodo Agung Sugeng
Published: July 2024

During the summer season in subtropical countries and the dry season in tropical countries, air temperature is high. To adapt this condition, an air conditioning (AC) unit is used. The air conditioning use, however, increases the electrical energy consumption which contributes to the increase of indirect CO2 emissions. For many buildings, a monthly electrical energy cost from the use of AC system can contribute up to 40% of a monthly utility expenditure. It is then a great motivation to decrease electrical energy consumption of the AC unit. In this work, an adaptable preventive maintenance for an AC unit shows an acceptable level of electrical energy decrease. An experiment was performed for 2 AC types. The first one is a wall mounted unit with a cooling capacity of 9,300 BTUH.  The second unit is a split duct unit with a cooling capacity of 48,000 BTUH. The cleaning of evaporator in the wall-mounted AC unit decreased the hourly electrical energy consumption by 4.1% from 810 to 777 Watt-hour. In addition, cleaning of condenser for the similar AC unit decreased the electrical energy consumption by 6.2% from 810 to 760 Watt-hour. Meanwhile, the evaporator cleaning for a 48,000 split duct AC decreased the hourly electrical energy consumption by 2.4% from 4.64 to 4.53 kWh and cleaning of condenser decreased the energy consumption by 5.4% from 4.64 to 4.39 kWh. If this electrical energy decrease could be scaled up to the global energy consumption from the air conditioning use, this should be a significant decrease of the global energy consumption and the correlated indirect CO2 emissions from the air conditioning sector.
Liminal Solidarity: How Ukrainian Refugee Mothers Negotiate Situational Kinship in a Collective Reception Centre in Belgium
Authors: Grondelaers Hannah
Published: July 2024

While solidarity practices among refugees have increasingly drawn scholars' interest, hardly any research has addressed the complex relationships between refugee women in the specific context of collective reception centres. At the same time, there has not been accounted for the way in which specific intersectional identities of refugee mothers shape mutual solidarity. Literature on refugee solidarity often analyses solidarity with an overdetermined political reading, which precludes the context in which solidarity emerges from being adequately researched. Based on my ethnographic research with Ukrainian refugee mothers in an emergency reception centre in Belgium, I propose a conceptualisation of solidarity that acknowledges that overlapping, intersectional identities do not automatically generate belonging. I argue for employing a situated intersectional lens (Yuval-Davis, 2015), and combining 'situational kinship' (Nelson, 2013) with 'resilient moves' (Groeninck et al., 2020) in order to grasp how the mothers’ navigating of the specific liminal and intersectional context of the reception centre, produced everyday practices of solidarity.
De Goaldene Brulloft fan Paulus Scheltema
Authors: Breuker Philippus
Published: July 2024

Paulus Scheltema’s De Goaldene Brulloft is a short prose story, written in Frisian, about a golden wedding anniversary in a well-to-do farmer’s family in 1664. The story is complemented with a biography of a man who attended the feast when he was ten years old, together with the names of his ancestors. It is written in an archaizing language, as is only known from Scheltema. Ten versions of the story are known, all of them undated. They resemble each other, but still differ somewhat. Two of them have been published earlier, the one, edited here, in 1831, the other one in 1841. The 1831 version distinguishes itself from the other nine by adding a kind of justification by the author and a multitude of adoptions from Gysbert Japix. In this article, I seek to answer a number of questions concerning occasion, influences and idea to write a story about this subject; to establish the date and development of the various versions; to uncover the reason and nature of the language; to unravel fact from fiction; to determine the author’s attitude towards the past in literary prose; and to assess the relation with the prevailing literary fashion.
Helgoländisch mut: von finitem Modalverb zu epistemischer Partikel
Authors: Hoekstra Jarich , Wolpers Eileen
Published: July 2024

In the Frisian dialect of Heligoland sentences are found which apparently contain two finite verbs, the modal verb mut ‘must’ in the verb second position and a full verb in the verb final position. It will be argued that the original 3rd person present form mut developed into an epistemic particle, so that the inflection shifted to the former infinitive. The grammaticalization of this particle, its spread from deliberative questions to declarative clauses and its epistemic status are discussed in some detail. The epistemic particle mut in Heligolandic is compared to similar particles occupying the verb second position in West and North Germanic languages.
Producción editorial criminal en Michoacán, en busca de legitimidad y autoridad criminal
Authors: Peña-González Rodrigo
Published: July 2024

Este artículo analiza un corpus de seis textos escritos y publicados bajo el “sello editorial” de dos organizaciones criminales en Michoacán, México, que incluyen un desplegado en prensa, una autobiografía, un código de conducta, una narración periodística, un texto de propaganda y uno motivacional, enfocado en la búsqueda de legitimidad política de las organizaciones criminales. Este artículo argumenta que, a pesar de la heterogeneidad en los estilos narrativos, este corpus construye un solo mensaje político: un discurso de legitimidad vinculado a un proyecto para construir autoridad criminal. En primer lugar, se analiza la noción de legitimidad y de autoridad criminal; luego se aborda el contexto de crisis de legitimidad y autoridad que se vive en Michoacán y México; a continuación, se analiza cada texto, sus características y su propósito. Finalmente, se discuten los resultados y se plantean algunas ideas como conclusión.