bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbial Translocation and Immune Activation in HIV-1 Infected Pregnant Women
Authors: Mitchell Charles D. , Dominguez Sady , Roach Margaret , George Varghese , Rinaldi Stefano , Fischl Margaret , Potter Jonell , Tyson Brittany , Pahwa Savita
Published: October 2018

Background:

Immune Activation (IA) has been previously documented in both pregnant
(PG) and non-PG HIV-1 infected (HIV+) women as well as in HIV- uninfected PG women; the latter
as a result of the fetal allograft. To determine whether the combined effects of HIV and pregnancy
result in increased IA and whether IA is associated with Microbial Translocation (MT), we
performed a prospective, longitudinal, controlled study during pregnancy and the postpartum (PP)
period.

Methods:

HIV+ PG women had biomarkers of IA and MT tested at 12-20 weeks (T1), and 24-36
weeks (T2) of pregnancy and at 6-8 weeks Postpartum (T3). HIV+, non-PG women were tested at
comparable time points. HIV- PG women were tested at T1 only. HIV+ women were not started on
antiretroviral therapy (ART) until T1. Biomarkers of IA assessed included: CD4DR+, CD4CD38+,
CD4DR+CD38+, CD8DR+, CD8CD38+, and CD8DR+CD38+. Biomarkers of MT included LPS,
sCD14, and 16SrDNA.

Results:

30 HIV+PG women, 18 HIV+ non-PG and 10 HIV-PG were enrolled. In the HIV+
women, there were no differences in median age, viral load, % or absolute CD4 at entry. Significant
differences between T1 and T2 and between T1 and T3 were noted in CD8DR+CD38+ in HIV+PG
women after ART. CD4DR+, CD4DR+CD38+, and CD8DR+ decreased post ART in HIV+PG
women but a decline in IA was less evident in HIV+ non-PG. LPS decreased post ART by T3 in
both HIV+PG and HIV+ non-PG groups; 16SrDNA was elevated at all time points in both groups
when compared to control values, and declined post ART in the HIV+PG group. A subgroup of
HIV-PG at T1 had IA and MT as evidenced by several IA markers and increased LPS.

Conclusion:

The degree of IA and MT was similar among HIV+PG and HIV+ non-PG women followed
longitudinally. There was no incremental increase due to the combined effects of HIV and
pregnancy. Several markers of IA and MT (LPS, 16SrDNA) decreased post ART. IA and MT occurred
in a subgroup of HIV-PG women during the 1st trimester. Further study must be done to confirm
whether MT consistently occurs in some healthy women during PG.
Buckwheat Journey to Functional Food Sector
Authors: Pirzadah Tanveer Bilal , Malik Bisma , Tahir Inayatullah , Ul Rehman Reiaz
Published: October 2018

Background::

Buckwheat (Fagopyrum spp.), a dicot pseudocereal, has an immense potential
in the functional food sector pertinently due to high nutritional profile. It is a rich source of phenolic
compounds, phytosterols, fagopyrins, dietary fibre, lignans, vitamins, minerals, antioxidants
and unsaturated fatty acids. The buckwheat products include tea, honey, cakes, pancakes, cookies
and soba noodles are gluten-free and are thus important for coeliac disease patients.

Objective:

The current review discusses the comparative metadata analysis of amino acids, bioactive
constituents and livelihood framework of buckwheat.

Conclusion:

The biological value of buckwheat proteins is considerably high possessing the aminoacid
score of 100 and the comparative metadata analysis revealed that it is richer in lysine, histidine
and tryptophan than wheat, corn, barley and egg. Buckwheat seeds contain many fagopyritols
amongst which fagopyritols A1 is an active constituent in insulin signaling and thus helps to treat diabetes
and polycystic ovarian syndrome. The buckwheat crop is on decline which needs attention for
its conservation, cultivation and improvement thus we present its livelihood framework for human
welfare.
In silico Molecular Docking Study to Search New SGLT2 Inhibitor based on Dioxabicyclo[3.2.1] Octane Scaffold
Authors: Kumar Shubham , Khatik Gopal L. , Mittal Amit
Published: October 2018

Background:

Diabetes is a leading cause of high mortality rate in the world. Recently, SGLT2 inhibitors showed the promising result to treat diabetes and therefore several molecules are approved by the US FDA.

Objective:

SGLT2 inhibitors were designed based on dioxabicyclo[3.2.1] octane with the aim to search new lead molecule.

Methods:

The molecular structures were drawn in ChemBiodraw ultra and molecular docking study was performed by AutoDock Vina 1.5.6 software. The LogP and toxicity were predicted online using AlogP and Lazar in-silico respectively.

Results:

Among all the designed molecules, SK306 showed the maximum binding affinity against the 3dh4 SGLT2 protein of Vibrio parahaemolyticus. LogP values were also calculated in order to determine the lipophilic property of the best binding molecules which show LogP 2.82-3.79 in the range for good absorption and elimination, also predicted to be non-toxic.

Conclusion:

SGLT2 inhibitors were designed based on the dioxabicyclo [3.2.1] octane resulting in a new lead molecule with high binding affinity; also these molecules were predicted to be noncarcinogenic with low LogP.
Effects of Hydroxyl Group on the Interaction of Carboxylated Flavonoid Derivatives with S. Cerevisiae α-Glucosidase
Authors: Lu Huining , Qi Yanjiao , Zhao Yaming , Jin Nengzhi
Published: October 2018

Introduction:

Carboxyalkyl flavonoids derivatives are considered as effective inhibitors in reducing post-prandial hyperglycaemia.

Methods:

Combined with Density Functional Theory (DFT) and the theory of Atoms in Molecules (AIM), molecular docking and charge density analysis are carried out to understand the molecular flexibility, charge density distribution and the electrostatic properties of these carboxyalkyl derivatives.

Results:

Results show that the electron density of the chemical bond C14-O17 on B ring of molecule II increases while O17-H18 decreases at the active site, suggesting the existence of weak noncovalent interactions, most prominent of which are H-bonding and electrostatic interaction. When hydroxyl groups are introduced, the highest positive electrostatic potentials are distributed near the B ring hydroxyl hydrogen atom and the carboxyl hydrogen atom on the A ring. It was reported that quercetin has a considerably inhibitory activity to S. cerevisiae α-glucosidase, from the binding affinities, it is suggested that the position and number of hydroxyl groups on the B and C rings are also pivotal to the hypoglycemic activity when the long carboxyalkyl group is introduced into the A ring.

Conclusion:

It is concluded that the presence of three well-defined zones in the structure, both hydrophobicity alkyl, hydrophilicity carboxyl and hydroxyl groups are necessary.
Faktor determinan pemanfaatan tik dan pengaruhnya terhadap kinerja guru SMK di Kabupaten Gunungkidul
Authors: Destiana Bonita , Soenarto Soenarto
Published: October 2018

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh faktor sosial terhadap pemanfaatan TIK; (2) pengaruh kemudahan penggunaan terhadap pemanfaatan TIK; (3) pengaruh kesesuaian tugas terhadap pemanfaatan TIK; (4) pengaruh harapan hasil terhadap pemanfaatan TIK; dan (5) pengaruh pemanfaatan TIK terhadap kinerja guru. Penelitian ini merupakan penelitian ex-post facto, dilaksanakan pada empat SMK yang sudah menerapkan Kurikulum 2013 di Kabupaten Gunungkidul. Teknik pengambilan sampel dengan proportionale random sampling. Penentuan jumlah sampel menggunakan tabel Krejcie dan Morgan, untuk populasi sebanyak 377 maka sampel yang diambil sebanyak 191 guru. Validitas instrumen diketahui berdasarkan penilaian pakar dan analisis butir. Reliabilitas diketahui dengan menghitung koefisien Cronbach Alpha. Teknik analisis data dengan Partial Least Square (PLS). Hasil penelitian menunjukkan bahwa: (1) faktor sosial berpengaruh terhadap pemanfaatan TIK; (2) kemudahan penggunaan berpengaruh terhadap pemanfaatan TIK; (3) kesesuaian tugas berpengaruh terhadap pemanfaatan TIK; (4) harapan hasil tidak berpengaruh terhadap pemanfaatan TIK; dan (5) pemanfaatan TIK berpengaruh terhadap kinerja guru. DETERMINANT FACTORS OF ICT UTILIZATION AND THE EFFECT ON TEACHER PERFORMANCE OF SMK IN GUNUNGKIDUL DISTRICTAbstractThis study aimed to determine: (1) the effect of social factor on the ICT utilization; (2) the effect of ease of use on the ICT utilization; (3) the effect of job fit on the ICT utilization; (4) the effect of outcome expectancy on the ICT utilization; and (5) the effect of ICT utilization on the teachers performance. This study was an ex-post facto research, conducted in four SMKs that have implemented ‘Kurikulum 2013’ in Gunungkidul district. The sampling technique was proportionale random sampling. Based on Krejcie and Morgan’s table for determining sample size, for a population of 377 the sample could be taken as many as 191 teachers. The validity of the instrument was known based on expert judgment and item analysis. Reliability coefficient was determined by calculating Cronbach’s Alpha. The data analysis technique used was Partial Least Square (PLS). The results of this research show that: (1) the social factor affects the ICT utilization; (2) the ease of use affects the ICT utilization; (3) the job fit affects the ICT utilization; (4) the outcome expectancy doesn’t affect the ICT utilization; and (5)the ICT utilization affects the teachers performance.
Use of a Biofeedback Breathing App to Augment Poststress Physiological Recovery: Randomized Pilot Study
Authors: Plans David , Morelli Davide , Sütterlin Stefan , Ollis Lucie , Derbyshire Georgia , Cropley Mark
Published: October 2018

Background

The speed of physiological recovery from stress may be a marker for cardiovascular disease risk. Stress management programs that incorporate guided breathing have been shown to moderate the stress response and augment recovery.

Objective

The aim of this study was to examine the effectiveness of an app-based brief relaxation intervention (BioBase) for facilitating physiological recovery in individuals exposed to a brief psychological stressor.

Methods

A total of 75 participants (44 women) completed a stressor speech task and were randomly assigned to one of three conditions: control, rumination, or an app-based relaxation breathing (BioBase) conditions. Heart rate variability (HRV) was assessed as a measure of autonomic function at baseline (6 min), during stress (6 min), and during recovery (6 min).

Results

There was a significant increase in subjective stress following stress exposure, but the ratings returned to baseline after recovery in all three groups. In addition, there was a significant decrease in vagally mediated HRV in the poststress period. During recovery, the root mean square of successive differences (P<.001), the percentage of successive interbeat (RR) intervals that differ by >50 ms (pNN50; P<.001), and high-frequency (P<.02) HRV were significantly higher in the BioBase breathing condition than the rumination and control conditions. There was no difference in HRV values between the rumination and control conditions during recovery.

Conclusions

App-based relaxed breathing interventions could be effective in reducing cardiovascular disease risk. These results provide additional utility of biofeedback breathing in augmenting physiological recovery from psychological stress.
Profiling Commenters on Mental Health–Related Online Forums: A Methodological Example Focusing on Eating Disorder–Related Commenters (Preprint)
Authors: McCaig Duncan , Elliott Mark T , Siew Cynthia SQ , Walasek Lukasz , Meyer Caroline
Published: October 2018

BACKGROUND

Understanding the characteristics of commenters on mental health–related online forums is vital for the development of effective psychological interventions in these communities. The way in which commenters interact can enhance our understanding of their characteristics.

OBJECTIVE

Using eating disorder–related (EDR) forums as an example, this study detailed a methodology that aimed to determine subtypes of mental health–related forums and profile their commenters based on the other forums to which they contributed.

METHODS

The researchers identified all public EDR forums (with ≥500 contributing commenters between March 2017 and February 2018) on a large Web-based discussion platform (Reddit). A mixed-methods approach comprising network analysis with community detection, text mining, and manual review identified subtypes of EDR forums. For each subtype, another network analysis with community detection was conducted using the EDR forum commenter overlap between 50 forums on which the commenters also commented. The topics of forums in each detected community were then manually reviewed to identify the shared interests of each subtype of EDR forum commenters.

RESULTS

Six subtypes of EDR forums were identified, to which 14,024 commenters had contributed. The results focus on 2 subtypes—proeating disorder and thinspiration—and communities of commenters within both subtypes. Within the proeating disorder subtype, 3 communities of commenters were detected that related to the body and eating, mental health, and women, appearance, and mixed topics. With regard to the thinspiration group, 78.17% (849/1086) of commenters had also commented on pornographic forums and 16.66% (181/1086) had contributed to proeating disorder forums.

CONCLUSIONS

The article exemplifies a methodology that provides insight into subtypes of mental health–related forums and the characteristics of their commenters. The findings have implications for future research and Web-based psychological interventions. With the publicly available data and code provided, researchers can easily reproduce the analyses or utilize the methodology to investigate other mental health–related forums.
SEARCHING WIDELY OR DEEPLY? THE IMPACT OF OPEN INNOVATION ON INNOVATION AND INNOVATION PERFORMANCE AMONG INDONESIAN MANUFACTURING FIRMS
Authors: Hartono Arif , Kusumawardhani Ratih
Published: October 2018

Since the term Open Innovation (OI) was coined by Henry Chesbrough in 2003, OI studies have been frequently conducted. Surprisingly, OI insights, in the context of Indonesian firms, are scarce. Furthermore, there are no existing OI studies that use data derived from innovation surveys. Hence, this study attempts to close the gap in the literature, by providing insights into Indonesian firms’ openness toward external knowledge, and its impact on innovation performance. The main aim of this study is to investigate the impact of OI practices on Indonesian manufacturing firms’ propensity to innovate (i.e. their product, process, organization, and marketing) and innovation performance. Product and process innovations are grouped under the term technological innovation, while organization and marketing innovations are classified as non-technological innovation. Data used in this study were derived from the Indonesia Innovation Survey (IIS) 2011 that covered the period from 2009-2010. Following Laursen and Salter’s (2006) study, OI indicators consist of external search breadth (i.e. the number of external sources or search channels that firms rely upon in their innovative activities) and depth (the extent to which firms draw deeply from the different external sources or search channels) in innovation process. Undertaking logistic and tobit regressions, this study shows that in general, both breadth and depth significantly and positively affect technological and non-technological innovation, as well as innovation performance. However, the over-search on external knowledge, measured by breadth squared and depth squared, negatively and significantly influence innovation and innovation performance. This indicates that too much external knowledge, sourced during the innovation process will diminish the return of innovation. This study also finds an indication of a complementary relationship existing between internal R&D and external knowledge; meaning that the implementation of one knowledge-sourcing strategy (either sourcing from internal R&D or external knowledge) increases the marginal returns from another. Lastly, important implications related to theoretical and innovation strategies are proposed.
Optimization of Financial Resources for Growth of Spiritual Learning (Nishkam Karma Yoga—Desire Less Action) for Stress Management in Business Corporate Sector
Authors: Chopra Kamal Nain , Sharma Namrata , Behura Ajit
Published: October 2018

This paper deals with the Optimization of Financial Resources for Growth of Spiritual Learning (Nishkam Karma Yoga—Desire Less action) for Stress Management in Business Corporate Sector. The concept of Nishkam Karma Yoga—Activity without Desire has been explained, and it’s role in improving the performance of the managers to optimize the working of the firms has been discussed with a reference to the control of the financial resources for the growth of Institutes of spiritual learning on the basis of experiments performed by framing some Questionnaires, followed by certain mathematical computations.
Migración calificada de China, India y México dirigida a Estados Unidos: análisis de la reorientación del patrón migratorio en la época reciente
Authors: Aragonés Ana María , Salgado Uberto
Published: October 2018

Tras la crisis de 2008 se han observado cambios en los patrones migratorios, entre los que destacan crecientes flujos de migración altamente calificada que se dirigen a Estados Unidos, país que busca mantener el liderazgo en las innovaciones tecnológicas. Sin embargo, se enfrenta a condiciones estructurales adversas en el ámbito demográfico y educativo, que explica por qué la migración calificada se ha vuelto un componente central. Principalmente la proveniente de China e India; al satisfacer la gran demanda de trabajadores en áreas STEM (Ciencias, Tecnología, Ingeniería y Matemáticas por sus siglas en inglés) cuyos flujos superan a los flujos de migrantes mexicanos.
Copépodos parásitos (Siphonostomatoida: Pandaridae) de Prionace glauca e Isurus oxyrinchus, capturados en la costa central de Chile
Authors: Véliz Christian , López Zambra , González M. Teresa , Acuña Enzo
Published: October 2018

In the Chilean coast, sharks and rays are one of the least studied fish groups, therefore quantitative data about theirparasites are scarce or almost non existing. Copepod parasites were collected from different sites along corporal body of Prionace glauca (n= 12) and of Isurus oxyrinchus (n= 1) captured onboard cruise OCEARCH during March and April 2014. Three species belonging to the Pandaridae family were identified: Echthrogaleus coleoptratus, Dinemoura producta and Nessipus orientalis. The latter species is here recorded for the first time in Chilean waters. These copepods did not show infection site preferences along host body. Considering the wide range of hosts described for these parasite species, it is concluded they are generalist parasites of wide geographic distribution.
Comportamiento reproductivo y desarrollo de los estadios tempranos del bagre marino Aphos porosus, de la bahía de Valparaíso, Chile
Authors: Balbontín Fernando , Bustos Claudia A. , Landaeta Mauricio F.
Published: October 2018

Con el objetivo de estudiar el comportamiento reproductivo y describir los huevos y larvas del bagre Aphos porosus (Pisces: Batrachoididae), se realizaron observaciones durante 6 temporadas de desove en la zona intermareal rocoso de Montemar, bahía de Valparaíso, Chile. Se mantuvieron peces adultos en el laboratorio y se controló el desarrollo de huevos y larvas. También se realizó la fertilización artificial de huevos en el laboratorio. Se observó la llegada de los machos a la costa a partir de octubre, seguidos de las hembras en noviembre y diciembre de cada año. Los huevos fueron adheridos a las paredes verticales o inferiores de las piedras y grietas de las pozas del intermareal de Montemar y en las paredes de los estanques. Su diámetro fue de 5,3 ± 0,3 mm. La eclosión se produjo a los 18 d a 18,6°C y a los 21 d a 16,3°C. Las larvas recién eclosionadas midieron en promedio 4,8 mm de longitud total (LT) (rango entre 4,3 a 5,1 mm LT) y realizaron parte de su desarrollo adheridas al sustrato por el saco vitelino. Antes de consumir completamente el vitelo, las larvas ya presentaban el patrón de pigmentación y la forma del cuerpo similar a la de los juveniles. Al terminar de absorber el vitelo, las larvas midieron 20,5 a 24,0 mm LT y se liberaron del sustrato entre los 60 y 65 d de edad. Este trabajo constituye un aporte sobre aspectos no descritos del comportamiento reproductivo y la ontogenia de A. porosus, dentro del conjunto de especies de peces de la costa de Chile
Interacciones tróficas de Australoheros facetus (Perciformes: Cichlidae), pez exótico en el humedal El Culebrón, Coquimbo, Chile
Authors: Avilés Jorge , López Amanda , Flores Héctor
Published: October 2018

Australoheros facetus se distribuye en los arroyos costeros de Uruguay y Río Grande do Sul en Brasil, Cuenca del río Paraná y región inferior del río Paraná en Argentina, con una gran capacidad de adaptación al ambiente. Esta especie es de interés para la acuariofilia y producto de esta actividad se han producido liberaciones en Sudamérica y Europa. En Chile, su introducción data desde 1940. Esta especie fue detectada habitando en el humedal El Culebrón, Coquimbo, Chile y surgen las preguntas de cuál será el impacto de esta especie introducida en las especies nativas, especialmente si su presa es el camarón de río Cryphiops caementarius. Para obtener información de sus hábitos alimentarios, junto con un grupo de estudiantes del colegio Guillermo Cereceda Rojas de Coquimbo, se efectuaron 3 muestreos entre el 2015 y 2016. Se capturaron 24 individuos con un 37,5% de hembras, los ejemplares más pequeños y los de mayor peso fueron machos. A los peces capturados se les registró su longitud total (Lt), peso total (Pt) y sexo. Se determinó la proporción de sexo, distribución de talla, relación Lt/Pt. Se analizó su contenido estomacal, aplicando los índices de frecuencia de ocurrencia, numérica y gravimétrica, determinando el índice de importancia relativa (IIR) y su respectivo porcentaje. Se obtuvo como resultado un crecimiento isométrico y no hubo diferencias en la relación Lt/Pt para hembras y machos. Se registró la presencia de 20 ítem presa (restos de plantas, Annelidae, Mollusca, Arthropoda y Pisces). Las presas mas importantes fueron peces (37,5% IIR), Cryphiops caementarius (25% IIR) y Chironomidaes (13,8% IIR). Se recomienda evaluar la presencia de esta especie, en otros sistemas hidrográficos de la región y en especial, el impacto de A. facetus en la depredación de camarón de río.
Relación longitud-peso, coloración y ubicación en el ambiente de juveniles de Pinguipes chilensis en Bahía La Herradura, Coquimbo, Chile
Authors: Flores Héctor , Araus María Ignacia
Published: October 2018

Pinguipes chilensis (Chilean sandperch) is an endemic species of the Southeast Pacific Ocean. Studies have generally included specimens of a total length (Lt) of more than 21 cm, there being no formal antecedents of specimens of a smaller Lt, weakness that motivates this study. It was determined for the Lt-Pt relation (Pt= 0.000005Lt3,1101, R2= 0.974) and Fulton’s average condition factor (0.81). Three ontogenetic color morphs are characterized, which are arranged in different environments and inhabit heterogeneous backgrounds, with sandy areas, others with abundant rocks and cracked rocks, which allow fish to take refuge
Os elos da cadeia produtiva e criativa da quadrilha junina Raio de Sol
Authors: Morais Isabela Andrade de Lima , Da Silva Diego Nélson
Published: October 2018

Este artigo apresenta e analisa a cadeia produtiva da economia criativa da Quadrilha Junina Raio de Sol com o objetivo de compreender o potencial econômico-criativo dessa cadeia. É um estudo de caso de natureza qualitativa, realizado através de pesquisa de campo através da observação participante e de entrevistas realizadas com atores pertencentes aos elos da cadeia produtiva da Raio de Sol. A abordagem parte da origem da manifestação cultural das quadrilhas juninas no Brasil; caracterização dos festejos juninos; transformações pertencentes ao movimento quadrilheiro no decorrer de seu percurso histórico; a economia criativa existente nos espetáculos e a cadeia produtiva da Junina Raio de Sol. Os resultados apresentam os principais elos da cadeia produtiva e criativa da Quadrilha Junina Raio de Sol.
Questões polêmicas sobre a economia criativa em territórios urbanos com carências socioeconômicas
Authors: Souza Israel Alves Jorge de
Published: October 2018

A partir da definição de territórios urbanos com carências socioeconômicas (TUCS), abrangendo favelas e áreas urbanas degradadas, pretende-se breve análise da economia criativa como estratégia de desenvolvimento territorial para em seguida percorrer questões polêmicas relacionadas. Trata-se de questões que remetem inclusive à própria relação histórica entre Portugal e Brasil, no âmbito do recorte metodológico da pesquisa que deu origem ao presente texto. Por um lado, há o posicionamento de que as iniciativas de indução da economia criativa podem se traduzir em imposições capitalistas que ameaçam as especificidades culturais dos TUCS. Por outro lado, entende-se que essas iniciativas podem ser encaradas como resgates e adaptações do clássico fenômeno urbano de balanço entre funcionalidades econômicas e criatividade, num viés flexível e positivo em prol do desenvolvimento.
Do football clubs with good governance have higher performances? Evidence from Brazil
Authors: Oliveira Marcio , Carvalhal Andre
Published: October 2018

There are many studies on corporate governance and performance of companies. However, the research on governance and performance of football clubs is scarce. This paper creates a football club governance index that allows us to analyze a larger number of clubs during a longer period of time when compared to previous studies. The authors study 20 Brazilian football clubs from 2005 to 2010 and find that clubs with good governance are more profitable, generate higher revenues, and win more championships domestically and abroad.
National corporate governance codes and IT governance transparency
Authors: Mohamad Shafi
Published: October 2018

The main purpose of this paper is to explore the influence of national corporate governance codes on IT governance transparency and was carried out by comparing the IT governance disclosure requirements across two jurisdictions Belgium and South Africa using the study by Huygh et al. (2017). The latter focused on these two countries since the South African corporate governance code King III (2009) contains detailed IT governance disclosures, while the Belgian corporate governance code Lippens (2009) does not. Huygh et al. (2017) found that listed South African financial services organizations were more concerned with disclosing their IT governance practices than their listed Belgian counterparts and that this observation held across the board for all four disclosure categories within the IT governance transparency framework. Further analysis at an individual item-level also found that many of the items for which the South African respondents reported frequently could be directly traced to the IT governance principles and recommended practices contained in the King III (2009) corporate governance code. Huygh et al. (2017) attributed the higher IT governance transparency of the South African respondents to the specific reporting requirements of their national corporate governance code King III (2009). Hence the recommendation that IT governance disclosures be proactively encouraged via national corporate governance codes to further enhance transparency.
Spiritual support as a part of palliative care of lung cancer patients
Authors: Lalic Nensi , Lalic Ivica , Tomic Sanja , Dolinaj Vladimir , Kasikovic-Lecic Svetlana
Published: October 2018

Introduction. Healthcare workers should check if an oncology patient would
like to be visited by a priest and if there are any religious rituals that
would ease the treatment and eliminate the stress of people close to them.
The aims of study have been to check if a lung cancer patient requires help
from a priest during palliative oncological treatment and if a team for
palliative care requires the presence of a priest. Material and Methods. The
study included 200 lung cancer patients treated between 2015 and 2017 at the
Institute for Pulmonary Diseases of Vojvodina. The sample was divided into
two groups: patients with I, II, IIIA stage of carcinoma and the other with
stadium of IIIB and IV. The research was performed by using a questionnaire
to be completed by the patients. Results. A statistical significance was
determined for the question ?Do you think that the priest can participate in
your treatment?? The percentage of male and female patients who answered
positively was 38.9% and 71.6%, respectively (p<0.001). As for the patients
with the stage of the disease IIIA and stage IIIB and IV, that percentage
was 24.4%, and 71.1%, respectively (p<0.001). Conclusion. Lung cancer
patients need help from a priest which is more common in females and in
patients in later stages of the disease. The team for palliative care of
lung cancer patients also needs the participation of a priest in their work
with these patients.
The assessment of patient safety culture - the psychometric study of the Serbian version of the questionnaire hospital survey on patient safety culture
Authors: Brestovacki-Svitlica Branislava , Milutinovic Dragana , Bozic Andrea , Maletin Srdjan , Lalic Ivica
Published: October 2018

Introduction. The advancement of patient safety culture within a health
institution is the basic component of reduction of errors and the
improvement of the general quality of healthcare. The aim of this study was
to assess the patient safety culture by means of Hospital Survey on Patient
Safety Culture in the Serbian setting. Material and Methods. The survey was
conducted in five health institutions in the form of cross section study,
which included 1,435 health care workers. Results. Nine dimensions have been
selected out of 37 items by explorative factor analysis. The total
percentage of positive response was 51%. The highest (70%) and the lowest
(33%) percentage of positive responses were obtained in the dimensions
?Overall perceptions of safety? and ?Nonpunitive response to errors?,
respectively. More than half of the respondents assessed the patient safety
as excellent/very good. In the last 12 months, more than half of the
respondents have not reported an adverse event. Conclusions. The survey
results indicate that changes are necessary in all domains of patient safety
culture. Healthcare policy makers have to take responsibility for the
implementation of safety culture in every health institution. Patient safety
culture can be observed and advanced by full commitment of all those
involved in the health care system, understanding both the causes of adverse
events and errors, as well as by applying efficient methods to reduce them
to the minimum.
Attitudes and beliefs of nurses and technicians towards complementary-alternative medicine
Authors: Tomic Sanja , Malenkovic Goran , Lalic Ivica , Tomic Slobodan , Lalic Nensi
Published: October 2018

Introduction. Complementary and alternative medicine is used more and more in
the communities but there are differences in attitudes, beliefs and
knowledge about it among and within different medical professions. The aims
of this study are to determine the attitude of nurses and medical
technicians towards methods of complementary and alternative medicine and
to determine the levels of personal use and willingness to recommend their
patients methods of complementary and alternative medicine that have been
adopted by the Health Ministry of the Republic of Serbia. Material and
Methods. The research included 126 nurses and technicians. The survey was
conducted at the General Hospital in Subotica. The Complementary and
alternative medicine Health Belief Questionnaire was used to determine the
attitudes of nurses and technicians towards complementary and alternative
medicine. A custom questionnaire was designed for this study in order to
determine the willingness to recommend complementary and alternative
medicine to their patients. Results. The average score on the Health Belief
Questionnaire suggested the positive attitudes of nurses and technicians.
There was a positive correlation between the attitudes and recommendations
given to the patients to accept diagnostic and treatment methods and
rehabilitation methods. The most recommended methods to the patients were
those used by the participants themselves. Conclusion. Most of the nurses
and technicians have the positive attitude towards complementary and
alternative medicine, and this can be a result of positive personal
experience and at the same time a reason that explains the recommendations
given to the patients.
Karakteristik Habitat Banteng (Bos javanicus d'Alton, 1823) di Resort Rowobendo Taman Nasional Alas Purwo
Authors: Purnomo Danang Wahyu , Pudyatmoko Satyawan
Published: October 2018

Fragmentasi habitat dan perburuan liar telah menyebabkan penurunan populasi alami
banteng. Sementara itu, sistem pengelolaan habitat di Taman Nasional Alas Purwo tidak sesuai
dengan karakter tiap-tiap tipe habitat yang ada. Penelitian ini bertujuan mengidentifikasi
karakter habitat yang dapat memberikan informasi tentang pemilihan habitat oleh banteng dan
faktor-faktor yang memengaruhinya. Karakter habitat diestimasi menggunakan dua
pendekatan, yaitu habitat-categorizing dan site-categorizing. Habitat-categorizing adalah
seleksi tipe habitat yang menunjukkan peluang beberapa tipe habitat untuk dipilih banteng.
Adapun site-categorizing adalah seleksi sumber daya pada suatu lokasi oleh banteng. Tipe
habitat yang memiliki peluang tertinggi untuk dipilih banteng adalah savana (nilai standar
seleksi B=0,59). Savana memiliki sumber daya melimpah terutama jenis-jenis pakan, yaitu
rumput lamuran (Arundinella setosa) dan merakan (Andropogon contortus) yang dikonsumsi
oleh banteng, dibandingkan tipe habitat lainnya. Tipe habitat lain yang sering digunakan
banteng adalah hutan pantai (B=0,173) dan hutan rawa (B=0,126). Tiga variabel habitat yang
memengaruhi pemilihan sumber daya adalah kerapatan rumput (peluang seleksi expÃŸ=1,036),
kerapatan tiang (expÃŸ=1,002), dan penutupan tajuk (expÃŸ=0,977).
Aplikasi Abu Sekam pada Padi Gogo (Oryza sativa L.) terhadap Kandungan Silikat dan Prolin Daun serta Amilosa dan Protein Biji
Authors: Yugi Rahayu Ahadiyat , Harjoso Tri
Published: October 2018

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh aplikasi abu sekam terhadap
kandungan prolin dan silikat daun serta kualitas hasil yaitu protein dan amilosa biji padi gogo
dan hubungan korelasi antar keempat komponen tersebut pada kondisi pertanaman 80 persen
kapasitas lapang pada skala pot. Penelitian dilakukan di polibag dalam screen house Fakultas
Pertanian Unsoed dengan menggunakan rancangan acak kelompok pola faktorial dengan
faktor varietas (Situ patenggang, Limboto, Towuti, Batutegi dan Aek sibundong) dan faktor
abu sekam (0, 2, 4, 6 t/ha), diulang tiga kali. Hasil penelitian menunjukan bahwa pemberian abu
sekam dosis 2âˆ’6 t/ha mampu meningkatkan kandungan silikat daun antara 18,49âˆ’29,43% dan
menurunkan kandungan amilosa biji pada lima varietas sekitar 4,19âˆ’6,92%. Pemberian abu
sekam dosis 2âˆ’6 t/ha mampu meningkatkan kandungan prolin daun antara 27,56âˆ’70,63% dan
protein biji antara 2,35âˆ’16,71%. Antarvarietas menunjukan bahwa kandungan prolin tertinggi
dihasilkan oleh varietas Batu tegi 18,58 persen dan protein biji pada varietas Situ patenggang
9,55%. Terdapat korelasi antar karakter fisiologis yaitu antara silikat-prolin (0,62) dan
kandungan protein-amilosa biji (-0,78).
Inventarisasi Ikan Hias Pantai Gunungkidul, Daerah Istimewa Yogyakarta: Sebuah Kajian Awal
Authors: Sidharta Boy Rahardjo , Probosunu Namastra , Suwarman Suwarman
Published: October 2018

Kajian â€œInventarisasi Ikan Hias di Pantai Gunungkidul, Daerah Istimewa Yogyakarta (DIY)â€
ini diharapkan dapat memberikan data yang lebih akurat dan tepat tentang keberadaan ikan
hias di kawasan ini. Kawasan kajian berdasar survei kawasan/lingkungan menetapkan delapan
(8) pantai di Kabupaten Gunungkidul sebagai lokasi kajian. Dari delapan pantai tersebut
didapat sebanyak 67 jenis ikan hias. Temuan ini seyogianya segera ditindaklanjuti oleh pihak
berwenang dalam bentuk penetapan rencana strategis (renstra) yang terkait dengan sumber
daya ikan hias, meliputi antara lain: rencana konservasi, pemintakatan (zonasi), pengelolaan,
pengembangan, dan pemanfaatan secara berkelanjutan.
Potensi Bekasam Bandeng (Chanos chanos) sebagai Sumber Angiotensin I Converting Enzyme Inhibitor
Authors: Wikandari Prima Retno , Suparmo Suparmo , Marsono Y. , Rahayu Endang S.
Published: October 2018

Bekasam adalah produk fermentasi ikan. Bekasam diduga mempunyai aktivitas Angiotensin I
Converting Enzyme (ACE) inhibitor, yang disebabkan oleh terbentuknya peptida ACE inhibitor
hasil aktivitas proteolitik enzim endogenous ikan dan bakteri asam laktat. Penelitian ini
bertujuan mengetahui perubahan populasi bakteri asam laktat, pH, total asam, perubahan
protein terlarut dan besarnya aktivitas ACE inhibitor selama proses fermentasi bekasam.
Jumlah populasi bakteri laktat meningkat dari 5,16 menjadi 8,15 log CFU/g, nilai pH menurun
dari 6,5 menjadi 4,41 disertai dengan peningkatan total asam. Bekasam bandeng menunjukkan
aktivitas antihipertensi sebesar 51,77% yang terbentuk pada hari ke 6, dan tidak menunjukkan
aktivitas penghambatan pada proses fermentasi selanjutnya. Besarnya aktivitas ACE inhibitor
berkorelasi dengan terjadinya kenaikan protein terlarut selama proses fermentasi bekasam.
Kekerabatan Jagung (Zea mays L.) Lokal Madura Berdasarkan Karakter Morfologi dan Penanda RAPD
Authors: Amzeri Achmad , Indradewa Didik , Setiadi Daryono Budi , Rachmawati Diah
Published: October 2018

Perbandingan metode yang berbeda pada perhitungan keragaman genetik dapat bermanfaat
dalam program pemuliaan dan konservasi tanaman. Pada penelitian ini digunakan 16 jagung
lokal yang dikoleksi dari pulau Madura. Sebanyak 57 sifat morfologi dan 10 primer RAPD
digunakan untuk menilai hubungan kekerabatan berdasarkan karakter morfologi dan penanda
RAPD, dan menentukan genotip jagung lokal Madura yang mempunyai sifat untuk
dikembangkan dalam program pemuliaan dan konservasi tanaman. Hasil penelitian
menunjukkan bahwa berdasarkan karakter morfologi dan penanda RAPD, 16 kultivar jagung
lokal di pulau Madura diklasifikasikan dalam 2 grup. Rata-rata kemiripan morfologi (0,74)
lebih tinggi dibanding kemiripan berdasarkan penanda RAPD (0,63). Koefisien kemiripan
berdasarkan karakter morfologi adalah 0,51ï€­0,91, sedangkan koefedien kemiripan
berdasarkan penanda RAPD adalah 0,39ï€­0,92. Lima kultivar (Tambin, Delima, Tambin-2,
Krajekan dan Duko) mempunyai produksi tinggi, umur genjah dan hubungan kekerabatan
agak jauh, sehingga digunakan untuk program pemuliaan dan pengembangan budidaya.
Respon Pertumbuhan dan Tingkat Ketergantungan Albizia saponaria (Lour.) Miq Terhadap Fungi Arbuskula Mikoriza Lokal Sulawesi Tenggara
Authors: Danu Tuheteru Faisal , Husna Husna , Alimuddin La Ode
Published: October 2018

Studi tentang pengaruh jenis FMA asli Sulawesi Tenggara pada tanaman A. saponaria belum
dilakukan. Tujuan penelitian ini mengetahui keefektivan pengaruh FMA lokal dan
ketergantungan tanaman A. saponaria. Penelitian dilakukan di rumah plastik kebun percobaan
Jurusan Kehutanan, Fakultas Pertanian, Universitas Haluoleo bulan Juniï€­September 2010.
Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan tiga kali ulangan.
Perlakuan meliputi tanpa inokulasi FMA (A), inokulasi inokulum FMA 10 g.
-1
polybag (B),
FMA 20 g.
-1
polybag (C). Parameter bibit yang diamati adalah tinggi, diameter batang, jumlah
daun, bobot kering pucuk, bobot kering akar, bobot kering total, nisbah pucuk akar, jumlah
nodul, persentase kolonisasi akar, dan ketergantungan relatif mikoriza. Hasil penelitian
menunjukkan bahwa inokulasi inokulum FMA 10 g.
-1
polybag (B) pada tanaman A. saponaria
memberikan pengaruh lebih baik terhadap peningkatan semua parameter yang diamati.
Terdapat pengaruh korelasi yang positif dan kuat antara persentase kolonisasi akar dengan
semua parameter pertumbuhan bibit (P
Karakteristik Mikrosatelit Gen BoLA dengan Penanda Primer RM 185 pada Sapi Bali (Bos indicus) di Nusa Penida
Authors: Suastika Putu , Puja I Ketut , Wandia I Nengah , Sulabda I Nyoman
Published: October 2018

Penelitian ini bertujuan menjelaskan distribusi frekuensi lokus gen bovine lymphocyte antigen
(BoLA) memakai primer RM 185 pada sapi bali dari Nusa Penida. Sebanyak 21 ekor sapi bali
yang berasal dari Nusa Penida diambil secara acak. Jumlah alel gen BoLA pada lokus RM 185
ada 7 macam alel yaitu 76 pb, 84 pb, 86 pb, 90 pb, 98 pb, 100 pb, dan 104 pb. Frekuensi tiap-
tiap alel yang teramati adalah 0,02%; 0,09%; 0,31%; 0,07%; 0,12%; 0,28%; dan 0,09%. Rata-
rata heterozigositas yang didapat adalah 0,804. Dapat disimpulkan, bahwa lokus RM 185 pada
gen BoLA sapi bali di Nusa Penida adalah sangat polimorfik di antara populasi.
Kemampuan Yogurt Sinbiotik Berbasis Probiotik Lokal dalam Mencegah Diare dan Meningkatkan Imunitas Tikus Putih (Rattus norvegicus)
Authors: Astawan Made , Wresdiyati Tutik , Isnafia Arief Irma , Dwi Utami Septi
Published: October 2018

Tujuan penelitian ini adalah mengamati kemampuan yogurt sinbiotik yang mengandung
probiotik lokal (Lactobacillus acidophilus 2B4) sebagai antidiare pada tikus yang terinfeksi
Enteropathogenic Escherichia coli (EPEC), dan untuk mendeteksi dampak terhadap
karakteristik imunomodulator (jumlah sel limfosit, kadar malonaldehid/MDA hati, dan
aktivitas antioksidan superoksida dismutase/SOD hati). Infeksi EPEC (10
7
cfu/ml/hari) yang
dilakukan secara oral ke tikus selama tujuh hari berturut-turut secara nyata menyebabkan
diare ringan tanpa penurunan berat badan. Pemberian secara oral yogurt sinbiotik yang
mengandung 10
9
cfu bakteri asam laktat/ml/hari selama 21 hari secara nyata meningkatkan
respons imun tikus, yang ditunjukkan dengan meningkatnya sel limfosit di hari ke-14,
penurunan MDA hati pada hari ke 14 dan 21, dan meningkatnya aktivitas SOD hati pada hari
ke-14.
Aktivitas Antiproliferatif Ekstrak Wasbensin Daun Eupatorium riparium Reg. : Studi In Vitro Pada HeLa Cell lin
Authors: Yhani Chrystomo Linus , Nugroho L. Hartanto , Wahyuono Subagus , Krishar Karim Aditya , Terada Kumiko , Nohno Tsutomu
Published: October 2018

Eupatorium riparium Reg. adalah tumbuhan obat penting asli dari Mexico dan India Barat, yang masuk ke tanah Jawa sejak tahun 1800. Tumbuhan ini mempunyai catatan sejarah digunakan untuk obat tradisional dalam berbagai kultur budaya bangsa secara luas di seluruh dunia dan biasa digunakan untuk obat hipertensi, gagal jantung, diuretik, antikanker, antifungi, dan penyakit yang disebabkan oleh bakteri. Studi pada HeLa cell line ini dilakukan selama satu bulan. Selanjutnya, studi ini bertujuan meneliti aktivitas antiproliferatif ekstrak wasbensin daun E. riparium terhadap kanker servik manusia Hela cell line. Aktivitas antiproliferatif diuji menggunakan reagen proliferatif sel WST-1 dengan waktu 1, 2, dan 4 jam setelah diinkubasi selama 72 jam pada suhu 37oC dan 5%CO2. Hasil penelitian menunjukkan bahwa ekstrak wasbensin daun E. riparium mempunyai aktivitas proliferatif yang potensial terhadap HeLa cell line dengan nilai IC50 berikut 102.69 ðœ‡g/ml (1 jam), 198.67 ðœ‡g/ml (2 jam). Saran selanjutnya, penelitian lanjutan perlu dilakukan untuk mengetahui mekanisme antikanker HeLa cell line.Kata kunci: Eupatorium riparium Reg, antiproliferatif, HeLa, WST-1
Amfibi dan Reptil Karst Gunung Sewu Zona Batur Agung, Gunung Kidul, Daerah Istimewa Yogyakarta
Authors: Qurniawan Tony Febri
Published: October 2018

An inventory study of amphibians and reptiles from Karst Zone Batur Agung Gunung Kidul, Yogyakarta was carried out for first time. Exploration was conducted in July-August 2007, May-June 2008 and April 2009 at four districts of Patuk, Playen, Ngawen and Gedangsari. The results showed findings of 9 species of amphibians and 22 species of reptiles. Total of those amphibians and reptiles were recorded, the largest species of amphibian was Duttaphrynus melanostictus (Bufonidae) and Fejervarya limnocharis (Dicroglossidae). The largest species of reptile was Hemydactylus frenatus (Gekkonidae), Lygosoma bowringii (Scincidae), Ramphotyphlops braminus (Typhlopidae), Eutropis multifasciata (Scincidae) and Ahaetulla prasina (Colubridae). Keywords: Biodiversity, herpetofauna, Wanagama forest, Wonosadi forest, Bunder forestAbstrakStudi inventarisasi amfibi dan reptil telah dilakukan untuk permata kali di Zona Karst Batur Agung Gunung Kidul Yogyakarta. Penelitian berlangsung dari bulan Juli-Agustus 2007, Mei-Juni 2008 dan April 2009 di empat kecamatan, yaitu Patuk, Playen, Ngawen, dan Gedangsari. Hasil penelitian menunjukkan bahwa ditemukan 9 jenis amfibi dan 22 jenis reptil. Total keseluruhan jumlah jenis amfibi dan reptil tersebut, jenis amfibi yang melimpah yaitu Duttaphrynus melanostictus (Bufonidae) dan Fejervarya limnocharis (Dicroglossidae). Jenis reptil yang melimpah yaitu Hemydactylus frenatus (Gekkonidae), Lygosoma bowringii (Scincidae), Ramphotyphlops braminus (Typhlopidae), Eutropis multifasciata (Scincidae) dan Ahaetulla prasina (Colubridae). Kata kunci: Biodiversitas, herpetofauna, hutan Wanagama, hutan Wonosadi, hutan Bunder
Profil Protein Isolat Bakteri Resisten Merkuri Dari Pertambangan Emas Rakyat Di Desa Pongkor, Bogor-Jawa Barat, Indonesia
Authors: Wahyu Irawati Patricia
Published: October 2018

Mercury pollution due to gold mining at Pongkor Village can threaten the life of organisms because mercury is toxic. Bioremediation can be considered to reduce mercury concentration in the water. The mercury-resistant bacteria can be isolated from the area and may be developed as mercury bioremediation agents. This study aims to isolate mercury-resistant bacteria, test their resistance to mercury, and conduct protein profile studies after mercury induction. The mercury-resistant bacteria were isolated from soil samples in the Pongkor Village gold mining area and the isolate resistance to HgCl2 was measured based on the Minimum Inhibitory Concentration (MIC) value. The protein profile was analyzed using SDS PAGE gel electrophoresis. The results showed that two of the most resistant bacterial isolates to mercury were HgP1 and HgP2 with MIC value was 575 ppm. The protein profile showed that mercury induced decreased protein synthesis under normal conditions and increased synthesis of one protein suspected to play a role in the mechanism of bacterial resistance to mercury.
Pengaruh Pakan Berbeda pada Induk Terhadap Jumlah Larva Ikan Guppy (Poecilia reticulata)
Authors: To’bungan Nelsiani
Published: October 2018

Ikan Guppy (Poecilia reticulata) merupakan salah satu jenis ikan hias yang cukup diminati, selain karena jenisnya beragam, karena pemeliharaann dan budidayanya terbilang cukup mudah. Efektifitas pakan terhadap pertumbuhan ikan budidaya, telah banyak diteliti. Namun, informasi terkait pengaruh pemberian pakan berbeda terhadap jumlah larva masih sangat jarang. Oleh sebab itu peru dilakukan penelitian terkait pengaruh pakan alami jentik nyamuk dan pakan buatan (pelet) terhadap jumlah larva ikan Guppy. Rancangan percobaan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap dengan 2 perlakuan (pakan jentik nyamuk dan pakan buatan) dengan masing-masing 3 ulangan. Prosedur penelitian meliputi tahap adaptasi, tahap pemeliharaan dan tahap pengumpulan data. Total larva ikan Guppy yang diberi pakan jentik nyamuk dari 3 ulangan adalah 115 ekor, sementara yang diberi pakan buatan (pelet) sebanyak 16 ekor. Uji hipotesis dengan One Way Anova menunjukkan pemberian pakan yang berbeda pada Induk tidak menghasilkan jumlah larva yang berbeda nyata. Data suhu yang diperoleh selama penelitian menunjukkan suhu ada pada kisaran 26-27OC, pH ada pada kisaran 6-7. Kandungan oksigen pada air yang digunakan untuk pemelihaaraan masih ada dalam rentang yang baik yaitu pada kisaran 4,66-7,61mg/L.