bluuebunny/crossref_metadata_2025 huggingface dataset:
Bullying victimization and non-suicidal self-injury in adolescents: parental phubbing and perceived school climate as moderators
Authors: Yang Ruirong , Gan Xiong , Wang Pinyi , Jin Xin
Published: September 2023

Background
There has been growing scholarly interest in understanding the adverse effects of bullying victimization on adolescents' development. However, it is less clear whether bullying victimization potentially increases adolescents' non-suicidal self-injury, to date, and the understanding of the factors, that may affect this relationship is also limited. The current study, therefore, examined the relationship between bullying victimization and non-suicidal self-injury in adolescents and sought to determine whether parental phubbing and perceived school climate simultaneously moderated this relationship.
Methods
The participants included 704 students (Mage = 15.15, SD = 0.98) from middle schools in China. They completed the questionnaires regarding their experience with bullying victimization, parental phubbing, perceived school climate and non-suicidal self-injury.
Results
The results indicated that adolescents with a high level of bullying victimization were likely to have a high level of non-suicidal self-injury, after controlling for age and gender. High parental phubbing adolescents who experienced higher levels of bullying victimization were more likely to be non-suicidal self-injury than low parental phubbing adolescents. Furthermore, higher levels of bullying victimization significantly predicted increases in adolescents' non-suicidal self-injury when they had high parental phubbing and low perceived school climate. In contrast, this effect became insignificant when parental phubbing was low and perceived school climate was high.
Conclusions
Our findings indicated bullying victimization affects non-suicidal self-injury in adolescents,This relationship is mediated by parental bowing and perceived school climate. Educators who are concerned about adolescents' non-suicidal self-injury should pay closer attention to parental phubbing, as well as their perceived school climate, to provide appropriate interventions.
An Extremely Rare Serovar of Salmonella Enterica (Yopougon) Discovered in a Western Whip Snake (Hierophis Viridiflavus) From Montecristo Island, Italy: Case Report and Review
Authors: Bene Andrea Francesco , Russini Valeria , Corradini Carlo , Vita Silvia , Pecchi Sabrina , Marchis Maria Laura , Terracciano Giuliana , Focardi Claudia , Montemaggiori Alessandro , Zuffi Marco A. L. , Weill François-Xavier , Bossù Teresa
Published: September 2023

Reptiles, including snakes, can be asymptomatically infected with multiple pathogen microorganisms, including Salmonella spp., which is considered an important concern for public and animal health. Small and uninhabited isles are quite ecologically different from mainland and represent interesting fields of study, in order to discover unexpected biological and microbiological aspects of their wild inhabitants. This work reports the presence of a very rare Salmonella enterica serotype, Yopougon, isolated in a carcass of a native wild snake (Hierophis viridiflavus) from an Italian uninhabited island of Mediterranean Sea, Montecristo. To our knowledge, S. enterica serotype Yopougon was previously isolated only once thirty-four years earlier in Ivory Coast, from a human fecal sample. Here, we present the genomic characterization of the new isolate, the phylogenetic comparison with the previously isolated S. enterica serotype Yopougon strain of human origin and with other sequences available in public databases. In addition, an extensive review of available data in the literature and from our case history is provided. Our finding represents an example of the ability of some pathogens to travel for very long distances within their hosts and then to infect others, even from different taxa.
Carboxylic acid reductase-dependent biosynthesis of eugenol and related allylphenols
Authors: Hanko Erik K. R. , Valdehuesa Kris Niño G. , Verhagen Koen J. A. , Chromy Jakub , Stoney Ruth A. , Chua Jeremy , Yan Cunyu , Roubos Johannes A. , Schmitz Joep , Breitling Rainer
Published: September 2023

Background

(Hydroxy)cinnamyl alcohols and allylphenols, including coniferyl alcohol and eugenol, are naturally occurring aromatic compounds widely utilised in pharmaceuticals, flavours, and fragrances. Traditionally, the heterologous biosynthesis of (hydroxy)cinnamyl alcohols from (hydroxy)cinnamic acids involved CoA-dependent activation of the substrate. However, a recently explored alternative pathway involving carboxylic acid reductase (CAR) has proven efficient in generating the (hydroxy)cinnamyl aldehyde intermediate without the need for CoA activation. In this study, we investigated the application of the CAR pathway for whole-cell bioconversion of a range of (hydroxy)cinnamic acids into their corresponding (hydroxy)cinnamyl alcohols. Furthermore, we sought to extend the pathway to enable the production of a variety of allylphenols and allylbenzene.

Results

By screening the activity of several heterologously expressed enzymes in crude cell lysates, we identified the combination of Segniliparus rugosus CAR (SrCAR) and Medicago sativa cinnamyl alcohol dehydrogenase (MsCAD2) as the most efficient enzymatic cascade for the two-step reduction of ferulic acid to coniferyl alcohol. To optimise the whole-cell bioconversion in Escherichia coli, we implemented a combinatorial approach to balance the gene expression levels of SrCAR and MsCAD2. This optimisation resulted in a coniferyl alcohol yield of almost 100%. Furthermore, we extended the pathway by incorporating coniferyl alcohol acyltransferase and eugenol synthase, which allowed for the production of eugenol with a titre of up to 1.61 mM (264 mg/L) from 3 mM ferulic acid. This improvement in titre surpasses previous achievements in the field employing a CoA-dependent coniferyl alcohol biosynthesis pathway. Our study not only demonstrated the successful utilisation of the CAR pathway for the biosynthesis of diverse (hydroxy)cinnamyl alcohols, such as p-coumaryl alcohol, caffeyl alcohol, cinnamyl alcohol, and sinapyl alcohol, from their corresponding (hydroxy)cinnamic acid precursors but also extended the pathway to produce allylphenols, including chavicol, hydroxychavicol, and methoxyeugenol. Notably, the microbial production of methoxyeugenol from sinapic acid represents a novel achievement.

Conclusion

The combination of SrCAR and MsCAD2 enzymes offers an efficient enzymatic cascade for the production of a wide array of (hydroxy)cinnamyl alcohols and, ultimately, allylphenols from their respective (hydroxy)cinnamic acids. This expands the range of value-added molecules that can be generated using microbial cell factories and creates new possibilities for applications in industries such as pharmaceuticals, flavours, and fragrances. These findings underscore the versatility of the CAR pathway, emphasising its potential in various biotechnological applications.
RETRACTED: Active and passive control of MHD Jeffrey nanofluid over a vertical plate with constant proportional Caputo fractional derivative
Authors: Abbas Shajar , Ahmad Mushtaq , Rahimzai Ariana Abdul , Nazar Mudassar , Khan Ilyas
Published: September 2023

The authors have requested that this preprint be removed from Research Square.
Confiding in Family Members about Mental and Physical Problems Could Improve the Mental Health of Evacuees: The Fukushima Health Management Survey
Authors: Horikoshi Naoko , Maeda Masaharu , Mizuki Rie , Murakami Michio , Iwasa Hajime , Yasumura Seiji
Published: September 2023

Background
After the Fukushima nuclear power plant accident in 2011, many victims experienced widespread evacuation away from their hometowns and family separation, affecting community social support. Affected individuals who have no one to communicate their concerns with could be at a high risk of psychological distress. Additionally, their families who provide guidance or encouragement are considered important sources of support. Therefore, we focused on evacuees confiding in family members and aimed to identify their relationship with psychological distress.
Methods
The study was a cross-sectional survey using a self-administered questionnaire for those aged ≥ 16 years. Poisson regression analysis was used to examine the association between psychological distress and having family members to confide in.
Results
The risk ratio (RR) by sex and age group was also examined. A regression analysis showed that the psychological distress of participants was significantly associated with having no family members to confide in, with an RR of 1.33 and a 95% confidence interval (CI) of 1.25–1.42. The RR by sex was 1.40 (95%CI:1.29–1.53) for women and 1.24 (95%CI:1.12–1.37) for men. Among the four age groups (16–25, 26–39, 40–64, and ≥ 65 years), RRs were generally higher in younger age groups (RR: 1.53, 1.88, 1.39, and 1.21; 95%CI: 1.12–2.07, 1.51–2.33, 1.25–1.54, and 1.10–1.33, respectively).
Conclusion
Among evacuees who had access to support, those who did not confide in their families were more likely to have mental health problems. Therefore, early identification of such high-risk individuals can help mitigate them.
Enhancing Biometric Characters of Perennial Sweet Pepper (Capsicum annuum L.) Treated by Potassium Silicate and Vinasse Grown under Greenhouse Conditions
Authors: Rady Mahmoud S. , Ghoneim Ibrahim M. , Feleafel Mostafa N. , Hassan Shimaa M.
Published: September 2023

Greenhouses are essential for ensuring a steady supply of high-quality vegetables like peppers, addressing global food security. Producers rely on innovative biostimulants to enhance plant growth in these controlled environments for cultivating crops effectively. This study aimed to investigate the impact of potassium silicate (PS) and vinasse treatments on the yield and biochemical constituents of perennial pepper plants cultivated in greenhouse conditions. For two consecutive seasons [2018/2019 and 2019/2020], pepper plants were sprayed by PS (0, 0.5, and 1 g/l) and drenched by vinasse (0, 1, 2, and 3 l/m3). To estimate the impact of PS and vinasse on the growth, yield, and biochemical constituents of pepper plants, fresh and dry biomasses, potential fruit yield, and some biochemical constituents were evaluated. Results revealed that 0.5 g/l of PS coupled with vinasse at 3 l/m³ generated the most remarkable enhancements in terms of plant biomasses, total leaf area, total yield, and fruit weight across both growing seasons. The implementation of vinasse at 3 l/m³ with 0.5 and 1 g/l of PS showcased the most pronounced augmentation in leaf contents encompassing chlorophyll index, nitrogen, and potassium, alongside improved fruit quality of total soluble solid and ascorbic acid contents. By leveraging these strategies, growers can significantly enhance plant growth potential, ultimately maximizing the production of superior sweet peppers.
An Early Detection Model For Social Media Rumors Considering Users' Emotional Characteristics
Authors: Xu Yong , Li Xiaoyu , Wang Hengna , Wang Xue’er , Abisado Mideth
Published: September 2023

Rumors in social media platform seriously affect social order and daily life. Aiming at the problem of early rumor detection in social media, this paper proposes a rumor early detection model, REDM, which integrates the historical behavior characteristics and emotional characteristics of UGC publishing subject users in social media. Firstly, the user feature index system of social media was constructed from the perspectives of basic features and user historical behavior features Fo, semantic features Fs and emotional features Fe of UGC corpus. Secondly, according to the UGC corpus released by user history, three behavioral characteristics of user history emotional tendency, emotional fluctuation and credit degree are calculated. Then, BERT model and CNN model were used to extract semantic features and emotion features of UGC corpus. Considering the temporal characteristics of UGC propagation, the RNN model was used for sequence modeling. Fs' , Fe' and Fo' obtained by fine-tuning Fo, Fs and Fe respectively are splicing into a single UGC corpus feature Fall, the characteristics of Fall_1, Fall_2, …, Fall_N of UGC corpus t1, t2, …, tN are entered into LSTM at each time to realize early rumor detection task. The experimental results show that the detection accuracy of the model proposed in this paper is better than other baseline models. The accuracy rate increased by 1.7% and the recall increased by 3.78%. At the same time, the rumor event detection in the early stage, less relevant posts context can also have a better performance.
Bilateral upper limb robot-assisted rehabilitation improves upper limb motor function in stroke patients: a study based on Quantitative EEG
Authors: Tang Congzhi , Zhou Ting , Zhang Yun , Yuan Runping , Zhao Xianghu , Yin Ruian , Song Pengfei , Liu Bo , Song Ruyan , Chen Wenli , Wang Hongxing
Published: September 2023

Background
Upper limb dysfunction after stroke seriously affects quality of life. Bilateral training has proven helpful in recovery of upper limb motor function in these patients. However, studies evaluating the effectiveness of bilateral upper limb robot-assisted training on improving motor function and quality of life in stroke patients are lacking. Quantitative electroencephalography (EEG) is noninvasive, simple, and monitors cerebral cortical activity, which can be used to evaluate the effectiveness of interventions. In this study, EEG was used to evaluate the effect of end-drive bilateral upper extremity robot-assisted training on upper extremity functional recovery in stroke patients.
Methods
24 stroke patients with hemiplegia were randomly divided into a conventional training (CT, n = 12) group or a bilateral upper limb robot-assisted training (BRT, n = 12) group. All patients received 60 minutes of routine rehabilitation treatment including rolling, transferring, sitting, standing, walking, etc per day, six days a week, for three consecutive weeks. The BRT group added 30 minutes of bilateral upper limb robot-assisted training per day, while the CT group added 30 minutes of upper limb training (routine occupational therapy) per day, six days a week, for three weeks. The primary outcome index to evaluate upper limb motor function was the Fugl-Meyer functional score upper limb component (FMA-UE), with the secondary outcome of activities of daily living (ADL), assessed by the modified Barthel index (MBI) score. Quantitative EEG was used to evaluate functional brain connectivity as well as alpha and beta power current source densities of the brain.
Results
Significant (p < 0.05) within-group differences were found in FMA-UE and MBI scores for both groups after treatment. A between-group comparison indicated the MBI score of the BRT group was significantly different from that of the CT group, whereas the FMA-UE score was not significantly different from that of the CT group after treatment. The differences of FMA-UE and MBI scores before and after treatment in the BRT group were significantly different as compared to the CT group. In addition, beta rhythm power spectrum energy was higher in the BRT group than in the CT group after treatment. Functional connectivity in the BRT group, under alpha and beta rhythms, was significantly increased in both the bilateral frontal and limbic lobes as compared to the CT group.
Conclusions
BRT outperformed CT in improving ADL in stroke patients within three months, and BRT facilitates the recovery of upper limb function by enhancing functional connectivity of the bilateral cerebral hemispheres.
Evaluation of Isotretinoin effects on depression, sleep apnea and sleep quality
Authors: Orenay Ozge Mine , Temel Berkay , Capci Arcan Kivanc , Bal Zulal Inci , Karaosmanoglu Nermin
Published: September 2023

Background
Isotretinoin is used to treat severe acne, treatment-resistant moderate acne and acne that leads to scarring or psychological distress. It has many side effects and is also associated with depression, sleep apnea and sleep disturbances.
Objectives
In this study, we aimed to evaluate the effects of isotretinoin on depression, sleep apnea and sleep quality.
Methods
A total of 42 patients diagnosed with acne and started isotretinoin treatment were included in the study. At baseline and after three months of treatment, patients filled out a questionnaire containing the Beck Depression Inventory (BDI), the Berlin Questionnaire (BQ) and the Pittsburg Sleep Quality Index (PSQI) in order to compare the effects of isotretinoin.
Results
There was no statistically significant difference in BDI, BQ and PSQI scores between week 0 and week 12 of treatment (p = 0.53, p = 0.5, p = 0.035).
Conclusion
This study showed no association between the use of isotretinoin and depression and sleep quality.
Microbial influences on black soldier fly reproduction: A focus on egg surface colonization
Authors: Heussler Carina Desirée , Klammsteiner Thomas , Stonig Katharina T. , Insam Heribert , Schlick-Steiner Birgit C. , Steiner Florian M.
Published: September 2023

Background
The growing global population increases the demand for protein, while the management of organic waste is becoming more challenging. Alternative protein sources are needed to reduce the negative environmental impact of food production. Lately, the black soldier fly (BSF) has been proposed as an ideal animal protein substitute due to its ability to consume and reduce diverse organic waste, thus solving two problems at the same time. Mass-rearing of BSF depends on flourishing reproduction, which is influenced by environmental and physiological factors. BSF females oviposit egg clutches near decomposing organic matter and conspecific eggs, with studies highlighting the crucial role of microorganisms in oviposition. In this study, we focus on the surface microbiota of the egg and its origin. We investigated if the microbiota are inoculated before, during, or actively after oviposition. For this purpose, we analysed the microbiota in the haemolymph and gut of larvae raised on sterilized and non-sterilized feed, the pupal cell pulp, the wash of the egg-laying apparatus and the eggs directly collected after oviposition, the ovarian eggs and the empty female abdomen, the eggs with contact to adult BSF, and sterilized eggs to assess the stage in BSF development during which the microbial colonization of the egg surface occurs.
Results
Our analysis revealed distinct bacterial profiles across life stages, indicating a shift from larval dominance of Enterobacteriaceae to a dominance of Burkholderiaceae on all analysed eggs. On genus level, larval stages were characterized by Morganella sp., Escherichia sp., and Proteus sp., transitioning later to less diverse communities in egg samples predominated by Burkholderia-Caballeronia-Paraburkholderia sp. While eggs from clutches and directly collected from the ovipositor generated viable offspring, surface sterilized eggs and eggs dissected from the ovary turned out to be nonviable. In microbiological cultivation trials, the established sterilization protocol was shown to be effective in removing viable microorganisms from the egg’s surface.
Conclusion
Our study reveals that while a predominant microbiota persists throughout all life stages, its composition undergoes a progressive transformation during maturation, particularly before oviposition. Gaining deeper insights into egg surface microbiota and the cues guiding oviposition has the potential to boost egg production and simplify mass harvesting of BSF larvae.
Frequency pushing enhanced by an exceptional point in an atom-cavity coupled system
Authors: Lee Joohye , Kim Jinuk , An Kyungwon
Published: September 2023

We observed the frequency pushing of the cavity resonance as a result of the coupling of the cavity field with the ground state 138Ba in a high-Q cavity. A weak probe laser propagated along the axis of a Fabry-Pérot cavity while ground-state barium atoms traversed the cavity mode perpendicularly. By operating the atom-cavity composite in the vicinity of an exceptional point, we could observe a greatly enhanced frequency shift of the cavity transmission peak, which was pushed away from the atomic resonance, resulting in up to 41±7 kHz frequency shift per atom from the cold cavity resonance. We analyzed our results by using the Maxwell-Schrödinger equation and obtained good agreement with the measurements.
Affirmative Action Policies and Interracial Marriage
Authors: Chen Shiyi
Published: September 2023

This paper explores the relationship between affirmative action policies and race relations by examining how interracial marriage patterns change in response to the enactment of state affirmative action laws. Specifically, this paper exploits time and state variation in initiating affirmative action laws along with fact that state affirmative action policies only directly affect public-sector employees to estimate a triple difference model. I find that the probability of a white male public-sector employee having a black wife increases by 0.08 percentage points if he married in a year when there was an affirmative action policy in place in his state of residence. Furthermore, affirmative action policies do not appear to affect the likelihood of white females marry black males nor the likelihood that black females marry white males. Taken together, these results suggest that affirmative action laws improve race relations but with important gender and racial differences.
JEL codes: J12 J78
Numerical simulation analysis of capacitive pressure sensors based on porous pyramidal microstructures
Authors: Javidi Reza , Zand Mahdi Moghimi , Majd Sara Alizadeh
Published: September 2023

Flexible wearable pressure sensors with high sensitivity have a wide range of applications in the field of healthcare monitoring, e-skin technology, robotic limbs, and other human-machine interaction under low pressures. For very low pressures, a sensor with high sensitivity and bulky, expensive measuring equipment is required to obtain the output signal. The incorporation of a micro-pyramidal porous dielectric section can considerably enhance the sensitivity of the capacitance-based pressure sensor. This article has employed a finite element method-based three-dimensional simulation to assess the performance of the porous microstructured capacitive pressure sensor (pmcps). The numerical results revealed a high level of agreement with the experimental data. To simplify the design and fabrication of the sensor with optimal performance, the effects of parameters such as sensor dielectric constant, dielectric layer porosity, base length, tip width, height, and inter-microstructural spacing of porous micro-pyramids were investigated using the response surface methodology. Sensitivity analysis showed that the tip width of the micro-pyramid has the greatest effect on sensor sensitivity and the least effect on the initial capacitance. Finally, equations were proposed for predicting the initial capacitance and sensor sensitivity based on the geometric parameters of the porous micro-pyramid and intrinsic properties of the dielectric section using three-dimensional finite element simulation to facilitate the ability to predict the fabrication and design process of the pmcps and optimize its performance for different applications.
Deforming reducible representations of surface and 2-orbifold groups
Authors: Porti Joan
Published: September 2023

For a compact 2-orbifold with negative Euler characteristic $\mathcal O^2$, the variety of characters of $\pi_1(\mathcal O^2)$ in $\mathrm{SL}_{n}(\mathbb R)$ is a non-singular manifold at $\mathbb C$-irreducible representations. In this paper we prove that when a $\mathbb C$-irreducible representation of $\pi_1(\mathcal O^2)$ in $\mathrm{SL}_{n}(\mathbb R)$ is viewed in $\mathrm{SL}_{n+1}(\mathbb R)$, then the variety of characters is singular, and we describe the singularity.
A previously unrecognized peculiarity of late-life human mortality kinetics?
Authors: Golubev A.
Published: September 2023

The late-life mortality kinetics in several species features the deceleration of mortality rate increase with age, which in humans starts at ca. 90 years. Being analyzed based on the Gompertz law µ(t)=µ0*e^gt with its inbuilt linearity of the dependency of lnµ(t) on t, this feature is interpreted as reflecting the heterogeneity of a population where the frailer subjects die out earlier thus increasing the proportion of those whose dying out is slower and leading to a decrease in the demographic (actuarial) rate of aging. Using Human Mortality Database data related to France, Sweden and Japan in the periods 2020 and 1920 and to the cohorts born in 1920, it is shown in the present communication that the putative deceleration of the demographic (actuarial) rate of aging in humans is preceded by an acceleration, which starts at about 65 years, reaches a peak, which at about 85 years is ca. 30% higher than the pre-acceleration level, and decelerates thereafter until 90 years at least, when the pre-acceleration level is reached. This peculiarity cannot be explained with the predominant dying out of frailer subjects at earlier ages. Its plausible explanation may be the real acceleration of the (averaged) biological aging in humans at ages above 65-70 years, which conspicuously coincide with retirement. The biological implications of this finding are discussed in terms of the generalized Gomperts-Makeham law µ(t)=C(t)+µ0e^f(t). In particular, the deceleration of mortality increase in the oldest-old subjects may be contributed to by the actual biological deceleration of aging.
Relevance of Data Analytics in Fisheries: Unveiling Insights for Sustainable Management - A Systematic Literature Review
Authors: Isaac Lukambagire , Baker Matovu , Bhavani Rao R. , Yildiz Meltem Alkoyak , N Remya S
Published: September 2023

The value of fish resources to socioeconomic development is immense. However, there is growing evidence that continuous fishing-both at sea and in freshwater sources is threatening the availability of fish resources evidenced by the dwindling fisheries resources. Cognizant of this, several fisheries institutions, governments, and local users have come up with several strategies to promote sustainable fishing. Unfortunately, most of the initiatives have not fully managed to repulse unsustainable fishing practices. Owing to this we use a systematic literature review to argue and present a case for governments and fishery management organizations to invest in data analytics as a new pathway that can give a comprehensive, near real-time view of both ocean resources and coastal fishing activities in light of the declining fish stocks and escalating environmental problems. The review documented that by using data analytics, governments, and fisheries management organizations/individuals may respond more swiftly to external forces like climate change and implement new policies and regulations thus promoting sustainable fisheries management.
Gravity Model betwen Portugal and Regional Blocs
Authors: Sandambi Nerhum
Published: September 2023

The article analyses foreign trade between Portugal and the regional economic blocs, from 1980 to 2018. The main objective is to analyse foreign trade between regional blocs and its implications. A static gravity model was estimated using the Fixed Effects (FE) model, Random Effects (RE) model, Ordinary Least Squares (OLS) model and the Hausman Taylor estimator. The results show a negative impact of the distance variable on foreign trade between Portugal and the regional blocs, with a negative impact of 11 per cent, especially when trade is with countries such as the USA and South Africa. The reer variable does not show the expected sign and has a relatively small impact.
Dietary assessment and nutrition pattern of maternal with gestation diabetes at Misurata Medical Centre
Authors: Mustafa Ayman , Elgenaidi Abdalla , Elwahaishi Salem , Embiriekah Salem
Published: September 2023

Background: The gestational diabetes mellitus (GDM) is yet another pregnancy complication for a pregnant woman, GDM happens when the body fails to produce enough insulin to regulate the sugar in blood. A healthy dietary regimen and eating behavior regarding GDM is a necessarily to ensure the health and development of pregnancy stages. Objectives: This study was conducted to assess nutrition patterns of gestation diabetes, also to correlate fasting blood glucose and HbA1c with anthropometric parameters, lifestyle and dietary pattern of maternal with GDM at Misurata. Materials and methods: Hospital-based cross section study was performed on 150 participants, whose selected randomly from Misurata Medical Centre (MMC). The data were collected thoroughly structured questionnaire and patient file. Result: The majority of participants (68 %) were fall with age group 20–35 years, greater of maternal at third trimester (55 %), maternal (22 %) had delivered babies with birth weight than 4 kg. Greater maternal (75 %) had family history with diabetes mellitus, whose diagnosed with polycystic ovary syndrome (19 %) and obesity (72 %) obese. The results revealed that majority of participant (84 %) hadn’t therapeutic diet. Highest rates of participants (57 %, 83 %, 80 %) had consumed high glycemic, fast and fatty food. Majority of participants (78 %) had elevated fasting blood glucose (≥120 mg/dl). Greater participants (92 %) had elevated HbA1c (≥6.5 %). Highly significant correlation (P≤0.01) of HbA1c and FBS with multi-pregnancies, age, birth weight and multiparty. Whereas, a significant correlation (P≤0.05) between weight birth, age, multi-pregnancy and abortion. Conclusion: the nutrition risks factors associated GDM will threatening health pregnancy unless the maternal committed with therapeutic diet plan
Evaluation of the use of combined extracorporeal detoxification in patients with severe acute pancreatitis: a retrospective cohort study
Authors: Masolitin S. V. , Protsenko Denis N. , Tyurin I. N. , Kim T. G. , Magomedov M. A. , Grishina L. A. , Gelfand E. B. , Ignatenko O. V. , Bykov A. O. , Kalinin E. Y. , Yaralyan A. V.
Published: September 2023

INTRODUCTION: Morbidity and mortality of severe acute pancreatitis (SAP) remains high. The most important direction of therapy is the relief of endotoxicosis. The use of extracorporeal detoxification (ECD) is a debatable problem. OBJECTIVE: Improving the results of treatment of patients with SAP, through the use of ECD methods. MATERIALS AND METHODS: The study included 25 patients. Group 1: ECD included 9 patients who used standard therapy with selective hemoperfusion (HP) and continuous veno-venous hemofiltration (CVVHF). Group 2 (control) 16 patients received standard therapy. We performed a comparative analysis of the main clinical and laboratory parameters and treatment outcomes between the groups. RESULTS: The use of ECD allowed to reduce the number of leukocytes from 14.9 to 8.6 × 109/l by 5 days of therapy in group 1, and from 17.6 to 16.1 × 109/l in group 2, respectively. The dynamics of CRP concentration from 1 to 5 days changed from 315.6 to 184.6 mg/ml and 274.2 to 352.9 mg/ml in groups 1 and 2, respectively. The level of PCT concentration on days 1–5 decreased from 4.5 to 2.1 ng/ml and 3.95 to 6.9 ng/ml in groups 1 and 2, respectively. The concentration of IL-6 decreased from 1624.3 to 914.3 pg/ml in group 1, and increased from 1529.8 to 1861.8 pg/ml in group 2, respectively. The dynamics of pH in group 1 was from 7.14 to 7.4 by the 5th day of therapy and 7.13 to 7.22 in group 2, respectively. SOFA by day 5 in group 1 was 4 points and 11 points in group 2, respectively. CONCLUSIONS: The use of HP and CVVHF in complex intensive care is accompanied by a significant regression of markers of endogenous intoxication, resolution of the acid-base state and reduces the severity of organ dysfunction and the risk of adverse outcomes, compared with standard treatment.
Structure and frequency of comorbidities and associated postoperative complications: a national observational multicenter study STOPRISK
Authors: Zabolotskikh Igor B. , Trembach N. V. , Magomedov M. A. , Popov A. S. , Malyshev Yu. P. , Dmitriev A. A. , Grigoryev E. V. , Fisher V. V. , Khoronenko V. E. , Kokhno V. N. , Spasova A. P. , Davydova V. R. , Gritsan A. I. , Lebedinskii K. M. , Dunts P. V. , Bayalieva A. Zh. , Ovezov A. M. , Martynov D. V. , Arikan N. G. , Kirov M. Yu. , Ershov V. I. , Pasechnik I. N. , Kuzovlev A. N. , Fedunets D. E.
Published: September 2023

INTRODUCTION: Risk assessment and identification of a group of patients with a high probability of developing an unfavorable outcome is the basis for effective prevention of postoperative adverse events. OBJECTIVE: The purpose of the study was to determine the structure and frequency of co-existing diseases in the preoperative period and associated adverse postoperative outcomes. MATERIALS AND METHODS: The analysis of the parameters of 8,241 patients of the STOPRISK database operated on abdominal and pelvic organs for the period from July 1, 2019 to April 30, 2022 was carried out. RESULTS: Co-existing diseases occurred in 4,638 patients (56.3 %), while one disease was observed in 1,872 patients (22.7 %), a combination of two diseases — in 1,383 patients (16.8 %), three diseases — in 814 patients (9.9 %), four diseases — in 395 patients (4.8 %), and more than 4 — in 170 patients (2.0 %). The most common were arterial hypertension — 48.2 %, chronic heart failure (20.7 %), coronary heart disease (19.3 %). The presence of one or more complications was recorded in 285 patients (3.5 %), fatal outcome — in 36 patients (0.43 %). 74.0 % of patients had a single complication, 14.0 % had a combination of two complications, and 12.0 % had a combination of three or more complications. The structure of complications was dominated by paralytic ileus (25.57 %), pneumonia (12.1 %), wound infection (12.1 %). Both mortality and the frequency of complications increased with an increase in the number of co-existing diseases. CONCLUSIONS: The most common co-existing diseases in abdominal surgery are arterial hypertension, chronic heart failure, coronary heart disease, diabetes mellitus and cardiac arrhythmia. The frequency of postoperative complications was 3.5 %, mortality was 0.43 %; the most frequent complications were paralytic ileus, wound infection and pneumonia.
Kenyamanan Antropometri Kursi Jemaat pada Bangunan Cagar Budaya Gereja Pandu, Kota Bandung
Authors: Gea Yemima Fatilinia , Hidayat Moh. Rizky Taufik , Nasir Muhamad Ridwan , Abinaya Muhammad Fathur
Published: September 2023

Title: Convenience of Anthropometric Church of The Church at The Cultural Reserve Building of Pandu Church, Bandung City
 
Anthropometry greatly influences comfort, especially for the Catholic Church of the Seven Sorrows Parish (Pandu Church) users in Bandung City as a place of worship. One of the most fundamental components of worship in a church is the need for church pews that conform to the anthropometric standards of its users. This study explores the comfort of using church pews in the Pandu Church of Bandung City. The research method employed is qualitative descriptive, involving data collection through sampling, research studies, and relevant literature searches related to the study object, as well as several stages according to the field implementation mechanism to obtain existing data and documentation. The analysis results show size, distance, and length differences between the two variations of church pews in the Pandu Church.
Comparison of the Identification of Emotional Facial Expressions from Full Faces with only the Eyes and the Mouth Regions in Young Indian Adults: an Exploratory Study
Authors: Bandyopadhyay Alapan , Samanta Sampriti , Mukherjee Abhijit
Published: September 2023

Background. Identification of emotional facial expressions (EFEs) is important in interpersonal communication. Six ‘universal’ EFEs are known, though accuracy of their identification varies. EFEs involve anatomical changes in certain regions of the face, especially eyes and mouth. But whether other areas of the face are just as important in their identification is still debated. This study was conducted to compare the accuracy of identification of universal EFEs under full-face and partial face conditions (only showing the eyes and the mouth regions). Methods. An analytical cross-sectional study was conducted among 140 young Indian adults. They were divided into two equal groups and shown the six universal EFEs in two sets, one with full-face images, and the other with images showing just the eyes and the mouth regions on a computer screen. The participants were asked to identify each of the EFE and their responses were analyzed. Results. Mean age was 21.3±1.7 yearsfor full face group, and 21.2±1.6 years for the partial face group. Most were men, from rural areas and from upper socioeconomic status families, and many of them were students. EFE identification was significantly higher for part-face group compared to full-face group (p-value .0007). Participants of both groups identified happiness the best (100%). For other EFEs, part-face images were identified more accurately than full-face images, except for disgust. These differences were statistically significant except for anger and fear. Conclusions. Among young Indian adults, accuracy of identification of universal EFEs washigh, which was significantly enhanced for all except disgust, when only combinations of eyes and mouth were shown, suggesting that other facial regions serve as distractors in EFE identification. Key Messages. 1. Identification of universal EFEs was higher from partialfaces (combination of eyes and mouth) as compared to full-face EFEs for all emotions except disgust. 2. This suggests that other regions of face serve as potential distractors in the identification of emotions, except for disgust, where these regions provide more information.
Relationship between cash holding and capital structure of Vietnamese public companies in the COVID-19 pandemic context
Authors: Thi Lan Anh Pham , Ngoc Hung Dang , Thi Thanh Binh Vu
Published: September 2023

Determining the capital and cash holdings pattern is among the most critical decisions of firm executives. This study investigates the link between cash holdings and capital structure to help executives consider the best pattern of capital and cash. The study collected a sample of 5,747 observations from public companies in Vietnam during 2019–2022 and employed the panel data regression method for analysis. The findings demonstrate a correlation between capital structure and cash holding ratio that is statistically significant. However, these relationships are inconsistent between the cash holdings and each component of the capital structure. Current debt and total debt ratios have a positive and linear association with cash holdings, while non-current debt ratio has a negative and nonlinear association. The study highlights a heterogeneous association of the cash holding ratio with three proxies of debt structure. The results reveal that, during COVID-19, the effects of the non-current debt ratio on cash holding and of cash holding on the current debt ratio have no statistical significance.
Does management of working capital enhance firm value? Empirical analysis of manufacturing enterprises in India
Authors: Gupta Rupali , Jatav Sunita , Prakash Gagan
Published: September 2023

The long-term financial health of a corporation is assessed by its capacity to meet short-term financial commitments. Optimum working capital that maximizes enterprise value varies across companies. The purpose of this paper is to investigate whether Indian manufacturing enterprises’ firm values are influenced by working capital management efficiency. The data are taken from 2016 to 2022 (a seven-year period) for 223 top BSE-listed manufacturing companies. Firm value (explained variable) is proxied using Tobin’s Q, and the constituents of working capital, which include the net trade cycle, inventory period, debtors’ collection period, and creditor payment period, are taken as explanatory variables. The study also controls for any differences in firm characteristics and economic conditions by employing firm size, age, current ratio, net profit ratio, sale growth and GDP growth rate. Balanced-panel data analysis is conducted by employing a two-step generalized method of moment technique. Net trade cycle, inventory period and debtors’ collection period are found to have a strong and significant positive impact on Tobin’s Q. The findings however did not report any evidence of the significant relationship between creditor payment period and Tobin’s Q. Additionally, the outcomes also evidenced that firm value is positively impacted by company size, net profit ratio, sales growth and GDP, whereas negatively affected by firm age. This paper suggests that manufacturing firms may potentially enhance their firm value by prolonging the net trade cycle, period of inventory and lengthening the credit period to customers till the level of attainment of an optimum working capital.
Exploring Urease Inhibition by Coumarin Derivatives through in silico and in vitro Methods
Authors: Fabris Marciéli , Camargo Priscila , Silva Mariana , Silva Talis , Machado Sérgio , Rodrigues Carlos , Lima Camilo , Albuquerque Magaly , Bispo Marcelle
Published: September 2023

In this report, we designed and synthesized ten N-(R-phenyl)-3-carboxamide-coumarin derivatives (2a-2j), exploring the coumarin nucleus, and an R-phenyl group as a structural scaffold and a peptide bond as a linker between them. The structure-activity relationships were investigated with different R-substituents (H, Br, NO2, Cl) in ortho, meta, or para positions from the phenyl group. Coumarins were obtained in good yields (72-95%), and in vitro screening against Canavalia ensiformis urease showed potential inhibitory percentages ranging from 42 to 65%. Half-maximal inhibitory concentration (IC50) values were determined for the best compounds 2b (R = 2-Br) and 2d (R = 4-Br). After conducting molecular docking and molecular dynamics on urease from C. ensiformis and Helicobacter pylori, potential binding modes for the most effective compounds 2b and 2d showed that these derivatives are able to interact with the crucial residue Cys592, thereby blocking the access of the urea substrate to the active site. According to density functional theory (DFT) calculations, 4-Br substitution on H. pylori urease was necessary for interacting with catalytic amino acids on the active site.
More movement with manure: increased mobility of erythromycin through agricultural soil in the presence of manure
Authors: Georgakakos Christine B. , Martínez Carmen Enid , Helbling Damian E. , Walter M. Todd
Published: September 2023

Antibiotic residues in the environment threaten soil and aquatic organisms and human and livestock health through the building of antimicrobial resistance. Manure spreading associated with animal agriculture is one source of environmental antibiotic residues. To better understand the risk of contamination, we studied the adsorption of erythromycin, a model macrolide antibiotic used across human and animal medicine. We conducted a series of equilibrium batch experiments to determine the kinetics and extent of adsorption and a continuous-flow column adsorption experiment to observe non-equilibrium adsorption patterns. We determined that the adsorption equilibration time to soil was approximately 72 h in our batch experiments. Erythromycin adsorbed to soil relatively strongly (K = 8.01 × 10−2 L/mg; qmax = 1.53 × 10−3 mg/mg), adsorbed to the soil in the presence of manure with less affinity (K = 1.99 × 10−4 L/mg) at a soil: manure ratio of 10:1 by mass, and did not adsorb to manure across the solid ratios tested. We observed multi-phased adsorption of erythromycin to the soil during the non-equilibrium column experiment, which was largely absent from the treatments with both soil and manure present. These results suggest that erythromycin is more mobile in the environment when introduced with manure, which is likely the largest source of agriculturally sourced environmental antibiotics.
Condorcet e a profissionalização docente na origem da escola pública
Authors: Pereira Coelho Marcos , Coelho João Paulo Pereira
Published: September 2023

Neste artigo, analisamos as proposições do filósofo Marie Jean Antoine Nicolas de Caritat, Marquês de Condorcet (1743 – 1794), para a profissionalização dos professores no contexto da Revolução Francesa.  A intenção foi compreender, historicamente, as asserções de Condorcet a respeito do recrutamento, seleção e organização do trabalho docente para o futuro sistema de ensino público francês. Para isso, foram examinados os critérios estipulados pelo autor para que os postulantes ao cargo pudessem concorrer, as qualidades almejadas nos futuros profissionais e as especificidades das tarefas atribuídas ao Estado e às sociedades científicas na organização dos trabalhos pedagógicos e administrativos. Essa divisão de responsabilidades incluía a escolha dos mestres, a remuneração, a garantia de estabilidade e a fiscalização do trabalho. Concluímos que Condorcet compreendeu que os professores seriam os agentes fundamentais pra o êxito da escola pública e forneceu as bases filosóficas, políticas e administrativas para a profissionalização docente.
Significados sobre a velhice segundo profissionais e gestores de serviços de cuidados de longa duração:
Authors: Gonçalves de Sousa Lara , Sanches Peres Rodrigo
Published: September 2023

O presente estudo teve como objetivos: (1) estabelecer um panorama da produção científica latino-americana qualitativa consagrada à exploração de significados relacionados à velhice segundo profissionais e gestores de serviços de cuidados de longa duração e (2) integrar criticamente seus respectivos resultados. Trata-se de uma metassíntese, na qual a ferramenta de busca sistemática SPIDER foi utilizada para elaborar a pergunta norteadora e para direcionar as consultas realizadas junto à Biblioteca Virtual em Saúde. As referências localizadas foram triadas e avaliadas independentemente por dois pesquisadores, sendo que a apreciação do conhecimento proporcionado pelas referências incluídas foi orientada pelos indicadores de consistência metodológica estabelecidos pela adaptação brasileira das diretrizes RATS. Já a integração interpretativa e crítica dos resultados reportados pelas referências incluídas foi viabilizada pelo recurso à análise temática indutiva. Foram incluídas 13 referências, todas desenvolvidas em serviços de cuidados de longa duração de caráter asilar, e 12 delas foram classificadas como metodologicamente consistentes. A análise temática indutiva levou à demarcação de dois temas emergentes, os quais revelam que, em consonância com os significados atribuídos à velhice por muitos profissionais e gestores de serviços de cuidados de longa duração de caráter asilar, a institucionalização de idosos representaria “um mal necessário” e estaria mais próxima de uma continuidade do que de uma ruptura, na medida em que acentuaria perdas que, supostamente, seriam inerentes ao envelhecimento. Novas pesquisas auxiliarão a esclarecer se essa mesma perspectiva é compartilhada por profissionais e gestores de serviços de cuidado de longa duração de caráter não-asilar.