bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Change in Peritoneal Function in Patients on Continuous Ambulatory PD vs Automated PD
Authors: Samad Nasreen , Fan Stanley L.
Published: October 2017

Background

Patients on automated peritoneal dialysis (APD) may have greater exposure to glucose in the PD fluid than those on continuous ambulatory PD (CAPD). If this causes long-term damage to the peritoneal membrane, it will have implications for a patient's choice of modality.

Methods

Membrane function of long-term APD or CAPD patients was followed prospectively. The data were collected from electronic patient records in our unit from 2000 to 2014. The rate of change in membrane transport status (D/Pcr) and ultrafiltration (UF4) for each patient was calculated using the least square regression line equation.

Results

We identified 106 APD and 123 CAPD patients who had a mean of 8.4 peritoneal equilibration test (PET) over 5.6 years. No differences were found in the rate of changes in D/Pcr or UF4. Baseline solute clearance (Kt/V) was lower in APD patients (1.66 vs 1.76, p = 0.04). However, APD patients experienced incremental changes to dialysis prescription that resulted in a greater increase in Kt/V compared with CAPD patients.

Conclusion

This is the largest study comparing the long-term effect of APD vs CAPD prescriptions. Despite more glucose being prescribed, there were no differences in the evolution of peritoneal membrane transport characteristics. The lower baseline Kt/V of APD patients might be explained by our aggressive use of incremental APD (tidal with dry day). Despite greater glucose prescriptions, initiating patients on APD based on patient preference appears to be safe for the long-term integrity of the peritoneal membrane.
Experiences of Living with Assisted Peritoneal Dialysis – A Qualitative Study
Authors: Petersson Ingrid , Lennerling Annette
Published: October 2017

Background

People's experiences of living with assisted peritoneal dialysis (aPD) have not been studied previously. Assisted PD is successfully used as renal replacement therapy for elderly and disabled patients with end-stage renal disease. To be treated with aPD implies being dependent on lifelong treatment at home. The aim of this study was to explore adults’ experiences of living with aPD.

Methods

In-depth interviews were conducted with 10 participants with aPD, median age 82.5 years. The text was analyzed using a phenomenological-hermeneutical method.

Results

The participants experienced limitations and an uncertain future, but through different strategies and participation in healthcare, they could still enjoy what was important in life for them. The analysis of the text resulted in 4 main themes; 1) Facing new demands, 2) Managing daily life, 3) Partnership in care, and 4) Experiencing a meaningful life, leading to the comprehensive understanding: ‘Striving for maintaining wellbeing’.

Conclusion

The participants expressed that they experienced a good quality of life despite being physically frail, severely ill, and in need of home-based lifesaving treatment. The findings suggest that aPD should be available everywhere where PD is offered. Integrating the model of person-centered care may greatly improve the care for persons living with aPD.
A Pilot Study of Okkidney, A Phosphate Counting Application in Patients on Peritoneal Dialysis
Authors: Imtiaz Rameez , Atkinson Katherine , Guerinet Julien , Wilson Kumanan , Leidecker Julie , Zimmerman Deborah
Published: October 2017

Background

Hyperphosphatemia is associated with adverse outcomes in patients treated with peritoneal dialysis (PD). We have shown that a fixed meal phosphate binder dosing schedule is not appropriate. The purpose of this study was to evaluate the beta version of OkKidney, a phosphate counting app that matches meal phosphate content with binder dose.

Methods

A convenience sample of adult patients treated with PD completed a pre-survey that included the technology readiness index (TRI 2.0). After a short information session, patients used OkKidney for 30 days. Pre- and post-intervention serum calcium, serum phosphate, and calcium carbonate binder intake were collected and compared using a paired t-test. A post-intervention survey using a 5-point Likert scale was used to gather patient feedback.

Results

Ten patients (5M, 5F) completed the study protocol. Participants were 55 ± 17 years old, predominately Caucasian, retired (60%), and owned a smartphone (70%). The median TRI score was 3.66 (max 5), indicating a moderate level of readiness. The post-survey results indicated a favorable rating for ease of use (μ = 4.4 ± 0.84) and usefulness (μ = 4.3 ± 0.68) of OkKidney. The average serum phosphate ( p = 0.99) and calcium ( p = 0.68) were not different pre-/post-intervention, but calcium carbonate intake tended to decrease ( p = 0.12).

Conclusion

Patients reported a positive experience with OkKidney. Further patient-specific adjustments of the binder dose to meal phosphate content may be required to demonstrate a statistically significant decrease in phosphate levels. We believe a larger trial is warranted to investigate the clinical implications of this app.
ESTONIAN TRAFFIC BEHAVIOUR MONITORING STUDIES 2001–2016:
OVERVIEW AND RESULTS
Authors: Ess Juri , Antov Dago
Published: October 2017

One of the most significant factors affecting road safety is human. Estonia has improved road safety dramatically
since its re-independence in 1991, and among the other reasons, this has happened due to changes in behaviour of
road users. Likely, at the same time, there have been annual studies conducted, aimed at measuring specific indicators
connected to compliance with road traffic law. As a result, one gets long-term trends in such indicators as compliance
with traffic signals, usage of seat belts, yielding to pedestrians at uncontrolled crossings. This paper aims to describe
Estonian traffic behaviour studies, analysing their results and pointing out actual problems in traffic behaviour. According
to the results of studies, all aspects of traffic behaviour showed positive trends, but these trends are different.
Certain indicators such as usage of seat belts have changed dramatically, while others like compliance with traffic signals
showed only moderate changes. The foremost problem in traffic behaviour is found out to be ignorance to yield
at uncontrolled pedestrian crossings. It is certainly one of the issues to deal with in the context of achieving Estonian
strategic goals in road safety.
A New Interpretation of the Period–Luminosity Sequences of Long-period Variables
Authors: Trabucchi Michele , Wood Peter R. , Montalbán Josefina , Marigo Paola , Pastorelli Giada , Girardi Léo
Published: October 2017

Period–luminosity (PL) sequences of long-period variables (LPVs) are commonly interpreted as different pulsation modes, but there is disagreement on the modal assignment. Here, we re-examine the observed PL sequences in the Large Magellanic Cloud, including the sequence of long secondary periods (LSPs), and their associated pulsation modes. First, we theoretically model the sequences using linear, radial, nonadiabatic pulsation models and a population synthesis model of the LMC red giants. Then, we use a semi-empirical approach to assign modes to the pulsation sequences by exploiting observed multi-mode pulsators. As a result of the combined approaches, we consistently find that sequences B and C′ both correspond to first overtone pulsation, although there are some fundamental mode pulsators at low luminosities on both sequences. The masses of these fundamental mode pulsators are larger at a given luminosity than the mass of the first overtone pulsators. These two sequences, B and C′, are separated by a small period interval in which large amplitude pulsation in a long secondary period (sequence D variability) occurs, meaning that the first overtone pulsation is not seen as the primary mode of pulsation. Observationally, this leads to the splitting of the first overtone pulsation sequence into the two observed sequences, B and C′. Our two independent examinations also show that sequences A′, A, and C correspond to third overtone, second overtone, and fundamental mode pulsation, respectively.
Extinction and the Dimming of KIC 8462852
Authors: Meng Huan Y. A. , Rieke George , Dubois Franky , Kennedy Grant , Marengo Massimo , Siegel Michael , Su Kate , Trueba Nicolas , Wyatt Mark , Boyajian Tabetha , Lisse C. M. , Logie Ludwig , Rau Steve , Vanaverbeke Sigfried
Published: October 2017

To test alternative hypotheses for the behavior of KIC 8462852, we obtained measurements of the star over a wide wavelength range from the UV to the mid-infrared from 2015 October through 2016 December, using Swift, Spitzer and AstroLAB IRIS. The star faded in a manner similar to the long-term fading seen in Kepler data about 1400 days previously. The dimming rate for the entire period reported is 22.1 ± 9.7 mmag yr−1 in the Swift wavebands, with amounts of 21.0 ± 4.5 mmag in the ground-based B measurements, 14.0 ± 4.5 mmag in V, and 13.0 ± 4.5 in R, and a rate of 5.0 ± 1.2 mmag yr−1 averaged over the two warm Spitzer bands. Although the dimming is small, it is seen at ≳3σ by three different observatories operating from the UV to the IR. The presence of long-term secular dimming means that previous spectral energy distribution models of the star based on photometric measurements taken years apart may not be accurate. We find that stellar models with

K and

best fit the Swift data from UV to optical. These models also show no excess in the near-simultaneous Spitzer photometry at 3.6 and 4.5 μm, although a longer wavelength excess from a substantial debris disk is still possible (e.g., as around Fomalhaut). The wavelength dependence of the fading favors a relatively neutral color (i.e.,

, but not flat across all the bands) compared with the extinction law for the general interstellar medium (

), suggesting that the dimming arises from circumstellar material.
Truncation of the Accretion Disk at One-third of the Eddington Limit in the Neutron Star Low-mass X-Ray Binary Aquila X-1
Authors: Ludlam R. M. , Miller J. M. , Degenaar N. , Sanna A. , Cackett E. M. , Altamirano D. , King A. L.
Published: October 2017

We perform a reflection study on a new observation of the neutron star (NS) low-mass X-ray binary Aquila X-1 taken with NuSTAR during the 2016 August outburst and compare with the 2014 July outburst. The source was captured at ∼32% L
Edd, which is over four times more luminous than the previous observation during the 2014 outburst. Both observations exhibit a broadened Fe line profile. Through reflection modeling, we determine that the inner disk is truncated

(where R

g
= GM/c
2) and

(errors quoted at the 90% confidence level). Fiducial NS parameters (M
NS = 1.4 M
⊙, R
NS = 10 km) give a stellar radius of R
NS = 4.85 R

g
; our measurements rule out a disk extending to that radius at more than the 6σ level of confidence. We are able to place an upper limit on the magnetic field strength of B ≤ 3.0–4.5 × 109 G at the magnetic poles, assuming that the disk is truncated at the magnetospheric radius in each case. This is consistent with previous estimates of the magnetic field strength for Aquila X-1. However, if the magnetosphere is not responsible for truncating the disk prior to the NS surface, we estimate a boundary layer with a maximum extent of

and

. Additionally, we compare the magnetic field strength inferred from the Fe line profile of Aquila X-1 and other NS low-mass X-ray binaries to known accreting millisecond X-ray pulsars.
A Detailed Comparison of Multidimensional Boltzmann Neutrino Transport Methods in Core-collapse Supernovae
Authors: Richers Sherwood , Nagakura Hiroki , Ott Christian D. , Dolence Joshua , Sumiyoshi Kohsuke , Yamada Shoichi
Published: October 2017

The mechanism driving core-collapse supernovae is sensitive to the interplay between matter and neutrino radiation. However, neutrino radiation transport is very difficult to simulate, and several radiation transport methods of varying levels of approximation are available. We carefully compare for the first time in multiple spatial dimensions the discrete ordinates (DO) code of Nagakura, Yamada, and Sumiyoshi and the Monte Carlo (MC) code Sedonu, under the assumptions of a static fluid background, flat spacetime, elastic scattering, and full special relativity. We find remarkably good agreement in all spectral, angular, and fluid interaction quantities, lending confidence to both methods. The DO method excels in determining the heating and cooling rates in the optically thick region. The MC method predicts sharper angular features due to the effectively infinite angular resolution, but struggles to drive down noise in quantities where subtractive cancellation is prevalent, such as the net gain in the protoneutron star and off-diagonal components of the Eddington tensor. We also find that errors in the angular moments of the distribution functions induced by neglecting velocity dependence are subdominant to those from limited momentum-space resolution. We briefly compare directly computed second angular moments to those predicted by popular algebraic two-moment closures, and we find that the errors from the approximate closures are comparable to the difference between the DO and MC methods. Included in this work is an improved Sedonu code, which now implements a fully special relativistic, time-independent version of the grid-agnostic MC random walk approximation.
Stellar Photometric Structures of the Host Galaxies of Nearby Type 1 Active Galactic Nuclei*
Authors: Kim Minjin , Ho Luis C. , Peng Chien Y. , Barth Aaron J. , Im Myungshin
Published: October 2017

We present detailed image analysis of rest-frame optical images of 235 low-redshift (z ≲ 0.35) Type 1 active galactic nuclei (AGNs) observed with the Hubble Space Telescope. The high-resolution images enable us to perform rigorous two-dimensional image modeling to decouple the luminous central point source from the host galaxy, which, when warranted, is further decomposed into its principal structural components (bulge, bar, and disk). In many cases, care must be taken to account for structural complexities such as spiral arms, tidal features, and overlapping or interacting companion galaxies. We employ Fourier modes to characterize the degree of asymmetry of the light distribution of the stars as a quantitative measure of morphological distortion due to interactions or mergers. We examine the dependence of the physical parameters of the host galaxies on the properties of the AGNs, namely, radio-loudness and the width of the broad emission lines. In accordance with previous studies, narrow-line (Hβ FWHM ≤ 2000 km s−1) Type 1 AGNs, in contrast to their broad-line (Hβ FWHM > 2000 km s−1) counterparts, are preferentially hosted in later-type, lower-luminosity galaxies, which have a higher incidence of pseudo-bulges, are more frequently barred, and are less morphologically disturbed. This suggests that narrow-line Type 1 AGNs experienced a more quiescent evolutionary history driven primarily by internal secular evolution instead of external dynamical perturbations. The fraction of AGN hosts showing merger signatures is larger for more luminous sources. Radio-loud AGNs generally preferentially live in earlier-type (bulge-dominated), more massive hosts, although a minority of them appear to contain a significant disk component. We do not find convincing evidence for enhanced merger signatures in the radio-loud population.
Reproduction sérielle d’un matériau odorant : de l’odeur sentie à la reconstruction collective de son souvenir
Authors: Cerisier Blandine , Haas Valérie , Kalampalikis Nikos
Published: October 2017

L’objectif de cet article est de cerner la dimension socialement construite du souvenir olfactif. Nous montrons dans quelle mesure les travaux théoriques et empiriques de Bartlett (1932) sur la mémoire permettent de systématiser les processus liés à l’élaboration collective du souvenir d’une odeur. Nous avons appliqué la technique de la reproduction sérielle à deux arômes différents au sein de neuf groupes composés de quatre participants (N=36). Les résultats montrent que la source potentielle de l’arôme apparaît comme un élément central dans la reconstruction collective de son souvenir. La construction graduelle du souvenir olfactif implique des omissions, des transpositions et une mise en relation des éléments qui le composent.
Regard et situation TAT en clinique adulte
Authors: Pheulpin Marie-Christine , Noir Bérangère , Bruguière Pascale , Benfredj Krinio
Published: October 2017

Si le regard et sa dimension pulsionnelle constituent une caractéristique essentielle et hautement conflictuelle de la situation projective, ils structurent de façon plus spécifique encore la situation TAT où les regards du sujet, du clinicien, et des personnages représentés sur les planches, se reflètent en de multiples jeux de miroir. Les auteures posent l’hypothèse que la situation TAT porte à son acmé l’énigme du regard. De Murray à l’École de Paris, l’évolution des dispositifs et consignes, et celle des contenus manifestes et sollicitations latentes, mettent en évidence cette problématique. De nouvelles perspectives s’ouvrent alors : la situation TAT semble susceptible de réactiver des expériences visuelles précoces, le regard des personnages se présente comme un champ de paradoxes et, enfin, l’énigme du regard paraît jouer comme un élément majeur de l’appel à la projection.
L’inachevé en soi
Authors: Lageira Jacinto
Published: October 2017

En suivant la notion fondamentale d’« instauration » dans ses diverses ramifications (artistique, ontologique, esthétique), cela jusqu’aux derniers textes de Souriau, on comprend que celle-ci est encore très pertinente pour les recherches actuelles, et qu’elle peut trouver à se prolonger, notamment dans une poétique et une théorie de l’action.
Esthétique et création
Authors: Sami-Ali
Published: October 2017

Dans ce travail, le contexte du banal et de la création a été abordé à partir de deux artistes Andy Warhol et Christian Boltanski. Une autre forme d’expression sera également décrite, elle concerne l’esthétique de la marginalité.
Pathologie création et psychothérapie des troubles psychosomatiques
Authors: Sami-Ali
Published: October 2017

D’origine égyptienne, professeur émérite de l’université Paris VII, Sami-Ali vit et travaille à Paris où il dirige le Centre International qu’il a créé. Ses activités sont multiples, il enseigne, soigne, écrit, traduit et peint. Après avoir été formé, il a exercé la psychanalyse, puis développé dans le sillage de Freud, la théorie et la clinique analytique pendant de nombreuses années. Son approche spécifique des troubles psychosomatiques l’a amené progressivement à rompre avec une pratique freudienne classique basée fondamentalement sur l’interprétation. Dans son livre, Corps et âme. Pratique de la théorie relationnelle (Dunod, 2003) et dans son livre Penser l’unité, il défend une conception novatrice de la psychothérapie des troubles « psychosomatiques » fondée centralement sur une approche unitaire du sujet.
Pathologie auto-immune et psychosomatique relationnelle
Authors: Sibony Daniel
Published: October 2017

Étude de cas clinique dans le cadre d’une activité spécifique de consultation en psychosomatique relationnel au sein d’une unité de psychiatrie de liaison au CHU de Nice. La relation psyché-soma, à partir du lien qu’il y a entre dépression et maladie somatique va nous autoriser à penser le lien entre relation biologique immunologique et relation psychique à travers les concepts de la psychosomatique relationnelle.
Adolescence délinquante, la relation et la création
Authors: Saragossi Jean-Baptiste
Published: October 2017

Si l’on peut considérer l’adolescence comme un temps singulier caractérisé par l’unité du corps et de l’âme, l’adolescence délinquante peut-elle être appréhendée comme un passage où s’impose la figure de la pathologie de l’adaptation et du Banal ? Par-delà une subjectivité sans sujet, on aurait alors à faire à un corps sans âme, dans lequel la pathologie organique serait ici remplacée par le primat des agir violents, des fugues et des conduites addictives. Peut-on alors penser les agir comme l’expression du refoulement des affects, et comme une modalité relationnelle impliquant l’adolescent et l’adulte qui lui fait face ? Si le fonctionnement de l’adolescent délinquant est marqué par le sceau du négatif, du neutre, propre au banal, il en est de même pour la création. Le point de départ est ici l’(a) créativité qu’il faut prendre en compte, le point médian étant la rencontre avec un thérapeute et les conditions d’émergence des affects dans la relation, le point d’arrivée et de départ, étant le retour des rêves dans la relation établie entre l’adulte et l’adolescent.
Créativité, changement et psychosomatique
Authors: Chahbazian Michèle
Published: October 2017

La créativité interroge la liberté et implique des questions d’éthique. L’équilibre psychosomatique nécessite une forme de circulation énergétique harmonieuse entre intérieur et extérieur. Les exigences de gestion entravent souvent nos aptitudes créatives. Faire prend la place d’être. Redonner sa place au corps peut éviter cet écueil, en rétablissant des repères de Temps et d’Espace, indispensables à la notion de profondeur.
Les salaires minima de branche en France
Authors: Gautier Erwan
Published: October 2017

Cet article décrit les principaux faits stylisés de l’ajustement des salaires de branche puis présente de nouveaux résultats sur l’impact de la hausse des salaires minima de branche sur la croissance des salaires de base en France. Pour cela, nous exploitons une base de données contenant environ 60 000 salaires minima de branche définis dans plus de 3 000 accords de branche pour environ 365 branches sur la période 2007-2016. Les hausses minima ont un impact significatif sur les salaires effectifs : une hausse de 1 % des salaires minima accroît les salaires effectifs d’environ 0,15 point de pourcentage (pp). Cet effet est 3 à 4 fois plus important dans certains secteurs de l’industrie manufacturière mais aussi dans le bâtiment et la construction.
Prison, peines alternatives et récidive
Authors: Henneguelle Anaïs , Monnery Benjamin
Published: October 2017

De nombreux pays tentent de réduire leur recours à l’incarcération dans leur lutte contre la délinquance, la prison étant une sanction coûteuse et souvent perçue comme peu efficace pour prévenir la récidive. Dans cet article, nous proposons une synthèse des recherches internationales récentes sur cette question, en nous concentrant sur les études expérimentales et quasi -expérimentales. Nous appliquons ensuite ces méthodes sur des données françaises afin d’évaluer les effets du bracelet électronique (en substitution totale aux courtes peines de prison), cette sanction s’étant progressivement imposée comme la principale peine alternative en France depuis son introduction en 2000.
Qu’apporte la sculpturation à la thérapie de couple ?
Authors: Cabrol-Malka Claire
Published: October 2017

Ce travail de recherche ambitionne d’étudier l’effet de la sculpturation sur les thérapies de couple, selon une démarche exploratoire et qualitative, s’inscrivant dans le paradigme de « l’efficacité réelle ». Deux sources de données de recherche ont été retenues : les entretiens thérapeutiques, réalisés en centre de thérapies familiales, et l’entretien de recherche avec la thérapeute. Les résultats mettent en évidence que les effets de la sculpturation diffèrent selon les thérapies étudiées. Ceux­ci ne sont pas toujours spectaculaires, et un effet manifeste après la sculpture est observé chez un seul couple : il s’agit d’un moment de grande intensité émotionnelle.
Perceptions of Nursing Students Regarding Usage of Art Therapy in Mental Health
Authors: Rice Robyn , Hunter Joyce , Spies Marty , Cooley Tracy
Published: October 2017

Background:

The purpose of this study was to explore the perceptions of baccalaureate nursing students regarding the use of art therapy to promote a therapeutic relationship and communication with mental health patients. A literature review revealed a lack of research on this topic.

Method:

This was a qualitative study using principles of thematic analysis.

Results:

Major themes found in the study included: Nursing Students' Initial Experiences With Mental Health Patients, Nursing Students' Observations of Mental Health Patients, and Nursing Students' and Mental Health Patients' Responses to Art Therapy.

Conclusion:

The intentional use of art therapy should be integrated into undergraduate nursing education. Further research should be conducted to determine whether art therapy is useful with students in other settings. In addition, innovations using art therapy in nursing education should be studied. [
J Nurs Educ.
2017;56(10):605–610.]
Opinions of Online Nursing Students Related to Working in Groups
Authors: Hampton Debra C. , El-Mallakh Peggy
Published: October 2017

Background:

The purpose of this study was to examine nursing students' perceptions regarding the usefulness of group work in online nursing programs, to identify challenges with online group work, and to determine which factors contribute to successful completion of online group assignments.

Method:

An online survey was used to obtain data for this qualitative descriptive study. The sample consisted of 217 nursing students in RN-to-Bachelor of Science in Nursing, Master's of Science in Nursing, and Doctor of Nursing Practice programs.

Results:

The majority of online nursing students preferred not to work on assignments in groups due to the challenges but realized the importance and value of doing so. Participants stated that the greatest challenges to effective group work included time management and unequal contributions of individual group members. Strategies that facilitated effective group work included identification of compatible group members, communication, establishment of clear expectations for time lines and organization, and oversight from the course instructors.

Conclusion:

Faculty need to implement strategies to result in positive learning experiences for online nursing students because working effectively in groups is a critical nursing skill. [
J Nurs Educ.
2017;56(10):611–616.]
Student Preparation to Care for Dying Patients: Assessing Outcomes Across a Curriculum
Authors: Lippe Megan , Jones Terry , Becker Heather , Carter Patricia
Published: October 2017

Background:

Most nurses are called on to care for dying patients in their professional practice. Yet, ineffective educational preparation to provide this care is consistently reported. An assessment of the preparation of nursing students and associated outcomes is needed to identify the effectiveness of various components of nursing education programs.

Method:

A study design involving cross-sectional surveys of five cohorts of nursing students in a baccalaureate nursing program was implemented. End-of-life education outcomes assessed included perceived competence, attitudes, and knowledge.

Results:

Mixed analysis of variance analyses supported significant cohort differences for attitudes and knowledge outcomes; perceived competence outcomes lacked significance.

Conclusion:

The pattern of between cohort differences identified suggests that students experience positive changes in knowledge and attitudes associated with academic progression. However, deficiencies persist that need to be addressed with targeted educational interventions. [
J Nurs Educ.
2017;56(10):633–637.]
SHIP-1 Deficiency in AID+ B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity
Authors: Chen Yingjia , Hu Fanlei , Dong Xuejiao , Zhao Meng , Wang Jing , Sun Xiaolin , Kim Tae Jin , Li Zhanguo , Liu Wanli
Published: October 2017

Unlike conventional B cells, regulatory B cells exhibit immunosuppressive functions to downregulate inflammation via IL-10 production. However, the molecular mechanism regulating the production of IL-10 is not fully understood. In this study, we report the finding that activation-induced cytidine deaminase (AID) is highly upregulated in the IL-10–competent B cell (B10) cell from Innp5dfl/flAicdaCre/+ mice, whereas the 5′ inositol phosphatase SHIP-1 is downregulated. Notably, SHIP-1 deficiency in AID+ B cells leads to a reduction in cell count and impaired IL-10 production by B10 cells. Furthermore, the Innp5dfl/flAicdaCre/+ mouse model shows B cell–dependent autoimmune lupus-like phenotypes, such as elevated IgG serum Abs, formation of spontaneous germinal centers, production of anti-dsDNA and anti-nuclear Abs, and the obvious deposition of IgG immune complexes in the kidney with age. We observe that these lupus-like phenotypes can be reversed by the adoptive transfer of B10 cells from control Innp5dfl/fl mice, but not from the Innp5dfl/flAicdaCre/+ mice. This finding highlights the importance of defective B10 cells in Innp5dfl/flAicdaCre/+ mice. Whereas p-Akt is significantly upregulated, MAPK and AP-1 activation is impaired in B10 cells from Innp5dfl/flAicdaCre/+ mice, resulting in the reduced production of IL-10. These results show that SHIP-1 is required for the maintenance of B10 cells and production of IL-10, and collectively suggests that SHIP-1 could be a new potential therapeutic target for the treatment of autoimmune diseases.
Clinical Heterogeneity in a Family with DKC1 Mutation, Dyskeratosis Congenita and Hoyeraal-Hreidarsson Syndrome in First Cousins
Authors: Olivieri Cristina , Mondino Anna , Chinello Matteo , Risso Alessandra , Finale Enrico , Lanciotti Marina , Guala Andrea
Published: October 2017

Dyskeratosis congenita (DC) is an inherited bone marrow failure disorder characterized by mucocutaneous features (skin pigmentation, nail dystrophy and oral leukoplakia), pulmonary fibrosis, hematologic and solid malignancies. Its severe form, recognized as Hoyeraal-Hreidarsson syndrome (HHS), also includes cerebellar hypoplasia, microcephaly, developmental delay and prenatal growth retardation. In literature phenotypic variability among DC patients sharing the same mutation is wellknown. To our knowledge this report describes for the first time a family of DC patients, characterized by a member with features of classic DC and another one with some features of HHS, both with the same mutation in DKC1. Our family confirms again that one mutation can be associated with different phenotypes and different hematological manifestations. It’s possible to speculate that there are likely to be patients who do not clinically fit neatly into either classical DC or HHS, but whose clinical features are due to mutations in DKC1 or in genes responsible for autosomal DC/HHS.
A theological evaluation of God business: A case study of the Prophetic Healing and Deliverance Ministries of Zimbabwe
Authors: Mahohoma Takesure C.
Published: October 2017

The issue of wealth accumulation by some leaders of neo-prophetic movements is a burning issue in the world, and Zimbabwe in particular. The emphasis on financial prosperity and health restoration as a fruit of commitment to prayer and faith has taken precedence within the Gospel. Recent insights from researchers have shown that Walter Magaya of Prophetic Healing and Deliverance (PHD) Ministries is among the richest Zimbabweans, while the country is facing economic doldrums and high unemployment. This article provides us with an example of research on how people grasp the Gospel, suffering and Christian teaching. The phenomenon of doing business in the name of God has spread to other parts of the world that include Africa. In treating this topic, I endeavoured to look at the PHD Ministries using secondary literature, participant observation and oral interviews to elaborate God business with first-hand experiences. The article is divided into five sections. These included the historical development of prosperity gospel, the foundation of PHD Ministries, the approaches of PHD Ministries, reasons why people are attracted to PHD Ministries, brief assessment of PHD Ministries and pastoral and spiritual recommendations. The aim of the article was to look at god business in the PHD Ministries through theological lenses. It sought to prove how religion had been used to make a multimillion dollar enterprise. The PHD Ministries portray wealth and health as the aim of Christianity which God promised. It shows that God only blesses those who sow the seed and believe. But according to Scripture, God blesses unconditionally. There is a narrow approach to interpreting Scripture, and as a result the minimised meaning and application of the texts are used to propagate the prosperity gospel.
Commercialisation of theological education as a challenge in the Neo-Pentecostal Charismatic churches
Authors: Resane Kelebogile T.
Published: October 2017

Commercialisation, technology, and globalisation impact all facets of religion.Commercialisation of religion contributes towards society’s obsession with success. One areathrough which commercialisation manifests itself is in theological education. This isexacerbated by the celebrity cult whereby the leader’s success is measured by wealthyappearance. The current legal accreditation requirements put pressure on the Neo-PentecostalCharismatic ministerial formation. The online courses come at a high price, as they alsopromote the popular literature that is not scholarly insightful. The Neo-Charismatic leadersundermine the formal theological training, since they claim to be taught by the Holy Spirit.
Christian activism and the fallists: What about reconciliation?
Authors: Headley Selena , Kobe Sandiswa L.
Published: October 2017

This article aims to understand what role Steve Biko and the Black Consciousness Movement, and the Soweto Uprising, played in Christian activism between the early 1970s and late 1980s. The question is: did the Black Consciousness Movement and the Soweto Uprising influence Christian activists to engage differently with notions such as reconciliation during the struggle against apartheid? The article revisits the actions and thinking of Christian activists before 1994 to understand some of their views on reconciliation, but most importantly, to understand their interactions, engagement with the Black Consciousness Movement and the Soweto Uprising. The article focuses on some of the church leaders and liberation theologians who were inspired and encouraged by Black Consciousness movements, including Allan Boesak and Desmond Tutu. To revisit their thinking and actions, in the heart of the struggle against apartheid, may help us understand current struggles on reconciliation, particularly in connection with the new generation of activists known as the Fallists. We may discover that the new generation is opening ‘old or new’ debates around reconciliation in South Africa.
Responses to migration: Tensions and ambiguities of churches in Pretoria Central and Mamelodi East
Authors: Renkin Wayne
Published: October 2017

This article is a result of research being conducted to explore how churches in two regions of the City of Tshwane – Pretoria Central and Mamelodi East – respond to urban change and vulnerability. Both regions are deeply affected by urban migration patterns. Firstly, I will explore various forms of migration – transnational, rural-urban, urban–suburban and generational – and the causes of migration – social-economic and political – as experienced and described by the churches themselves. Secondly, I will seek to reflect on some of the tensions or ambiguities of how churches respond to migration, how the identity, self-understanding or locatedness of churches inform their responses to migration, and/or how churches and their identity are shaped by migration – commuter or local church, home or temporary church.
Social entrepreneurship as a way of developing sustainable township economies
Authors: Manyaka-Boshielo Semape J.
Published: October 2017

This article investigates using social entrepreneurship as a way of developing sustainabletownship economies, so that poverty can be eradicated from the townships of South Africaand township dwellers can begin to play a role in the economic development of the country.The author also thinks it is God’s purpose for people to enjoy life, free from economic hardship.A reduction in poverty would also bring down the crime rate and other social ills. It starts bydefining and clarifying the concepts of ‘entrepreneur’ and ‘social entrepreneurship’. Itcontinues by looking in more depth into township life and its challenges. This is done throughreviewing the literature and observations obtained through participant observation research.Post-foundationalist practical theology believes in interdisciplinary dialogue as a means ofallowing the concept of social entrepreneurship to bring about a sustainable townshipeconomy. From the author’s observations, it became apparent that to see the attainment of asustainable township economy, training and development should start with a strong emphasison personal identity and interpersonal and business skills. The author, therefore, proposes aholistic approach to social entrepreneurship.
Yolanda Dreyer: Haar proses van bewusmaking – ’n Waarderende refleksie op haar bydrae tot die akademiese diskoers ten opsigte van die temas gender, huwelik en seksualiteit
Authors: Botha Annelie
Published: October 2017

The focus of this reflection on Yolanda Dreyer’s contribution to the academy is her research ongender, sexuality and marriage. The contributions she has made were written from a pastoralperspective and focused on pastoral interaction with women. The issues surrounding thechurch’s view on marriage does not only concern the roles given to women but also the placeand status that the church and society assigned to marriage as an institution. Her contributionin the area of sexuality is very closely linked to the insights she provides in her research onhomosexuality. How sexuality is seen has an impact on how homosexuality and heterosexualityare reflected on.
The Botsha Bophelo Adolescent Health Study: A profile of adolescents in Soweto, South Africa
Authors: Miller Cari L. , Nkala Busisiwe , Closson Kalysha , Chia Jason , Cui Zishan , Palmer Alexis , Hogg Robert , Kaida Angela , Gray Glenda , Dietrich Janan
Published: October 2017

Background: Youth between the ages of 15 years to 24 years account for almost half of new HIV infections in South Africa.Objectives: To describe the study details of the Botsha Bophelo Adolescent Health Study (BBAHS) which was an investigation of HIV risk among adolescents living in Soweto, South Africa.Methods: Eligibility criteria for the BBAHS included being 14 years – 19 years old and living in one of the 41 identified formal and informal areas in the township of Soweto. A cross-sectional survey was developed between investigators and an adolescent community advisory board consisting of previously validated scales and original questions including demographics, sexual and reproductive health, health service utilisation and psychosocial behaviours.Results: Between 2010 and 2012, interviewers administered surveys among 830 adolescents (57% females), whose median age was 17 years (Q1, Q3: 16, 18), and found that 43% of participants identified their ethnicity as Zulu, 52% reported high food insecurity, 37% reported at least one parent had died, 15% reported living in a shack and 83% identified as heterosexual. Over half of the participants (55%) reported ever having sex (49% of females and 64% of males), 11% of whom initiated sex at < 15 years of age (3% females and 21% males). Almost half (47%) reported ever testing for HIV, 3% (n = 12) of whom self-reported being HIV-positive and 33% (n = 4) were on antiretroviral therapy.Conclusion: Our study highlights important individual, relational and structural level determinants of HIV risk for adolescent men and women growing up within HIV hyperendemic settings.
Perceptions of Chinese and Tanzanian employees regarding intercultural collaboration
Authors: Mayer Claude-Hélène , Boness Christian M. , Louw Lynette
Published: October 2017

Orientation: Chinese organisations have a long tradition of operating in Tanzania, and even today, Tanzania is the gateway for Chinese interests entering sub-Saharan markets.Research purpose: The purpose of this article was to explore and understand the perceptions of Chinese and Tanzanian employees working in a private Chinese organisation in Tanzania.Motivation for the study: The authors would like to contribute to the discourse on Chinese and Tanzanian collaboration in southern Africa to improve context-based intercultural collaboration from a human resource management perspective.Research design, approach and method: The study used a case study approach within a hermeneutical research paradigm. Data were collected through semi-structured interviews and observation in a selected private Chinese organisation. Data were analysed by content analysis using Terre Blanche’s five-step model of content analysis.Main findings: The findings show that intercultural collaboration is a challenge for both Chinese and Tanzanian employees. Chinese employees share a mostly positive view of their organisation, while Tanzanians tend to be more critical. Members of both groups, however, feel that intercultural collaboration could improve if members of ‘the other group’ made recommended changes. Despite this, both groups adhere to their perceptions of ‘the other’ and maintain a favourable view of the self.Practical/managerial implications: Chinese organisations need to create opportunities for the improvement of intercultural collaboration by reflecting on the self and ‘the other’ in terms of understanding thought styles, experiences, knowledge, and the impact of cultural values on collaboration behaviour. As such, cultural knowledge-sharing might contribute to a sustainable long-term intercultural collaboration.Contribution: The study contributes to filling the gap of in-depth qualitative research on perceptions of Chinese and Tanzanian intercultural collaboration between employees in the field of human resource management in Africa.
A postfoundational ubuntu accepts the unwelcomed (by way of ‘process’ transversality)
Authors: Smith Wayne G.
Published: October 2017

This examination of ubuntu is engaged in a conversation with the speculative philosophy of organism (‘process’) to acquire an extended tool by which to engage within its ontology the widest possible range of human interaction. The engagement by ubuntu’s relational doctrine of the speculative philosophical cosmology of A.N. Whitehead placed portions of the latter’s constructs at the service of ubuntu’s transversal capacity to examine and apply the deepest understanding of its own etymology. It has been a challenge to understand occasions of injustice and suffering which have manifested within the same African culture which has given to the world the language and concept of ubuntu. It has been commonplace to isolate the utopian relational ontology implicit in the aphorism from occasions of the worst of human nature. It was the premise of this study that an understanding of an ubuntu which excludes dystopian occasions has done a disservice to the breadth, depth and height of what is to be fully human – including occasions of suffering and anti-social behaviours.
Voicing God: Theological Injunction to economic issues
Authors: Dube Zorodzai
Published: October 2017

Taking a socio-historical approach, this chapter traces history from World War II (WWII) and illustrates the various instances in which economics and politics intersect with theological themes. After WWII the dominant paradigm in theology tilted towards a moral economy by focusing on issues of fairness, justice and peace. This chapter argues that, in view of the triumph of global capitalism since 1989, the future and relevance of theology is located within spaces that provide ethical and moral influence towards fairness and justice, thus agreeing with the central message of Jesus of Nazareth.
A case of occipital rudimentary cephalocoele
Authors: Garge Saurabh , Menon Prema , Aggarwal Sumeet , Rao Kln
Published: October 2017

We report a case of a 1-month-old boy with a cystic swelling in the occipital region without intracranial communication, called atretic cephalocoele. We discuss clues to the diagnosis of atretic cephalocoeles. We also discuss common clinical findings and a possible mechanism by which these lesions develop.
Solitary giant extradural plasmacytoma
Authors: Raghavendra H , Kumar M , Panigraghi Manas , Reddy Shailaja
Published: October 2017

Solitary plasmacytoma of the skull is very rare, and only a few cases have been reported in the literature. It remains controversial whether solitary plasmacytoma of the skull is essentially identical with solitary plasmacytoma of bone or not. Solitary plasmacytoma of bone including solitary plasmacytoma of the skull is characterized by a radiologically solitary bone lesion, neoplastic plasma cells in the biopsy specimen, fewer than 5% plasma cells in bone marrow, <2.0 g/dl monoclonal protein in the serum when present and negative urine test for Bence Jones protein (monoclonal light chain). We report one case of a 70-year-old woman who referred to our hospital because of a progressive left parietal swelling. On clinical examination, a painless large soft mass in the right parietal region was observed. Computed tomography revealed an extra-axial mass in the in the left frontoparietal region. The lesion was totally excised despite the bleeding tendency. Histology disclosed the presence of a plasmacytoma. On follow-up examination, 7 months later no tumor recurrence or evidence of multiple myeloma was detected.
Comparison of stereotactic and ultrasound-guided biopsy of solid supratentorial tumor: A preliminary report
Authors: Satyarthee Guru , Chandra P , Sharma Bhawani , Mehta V
Published: October 2017

Introduction: The computed tomography (CT) guided stereotactic biopsy (STB) is considered as method of choice for biopsy of intracranial mass lesions. However, it's disadvantages are frame fixation, time requirement for transportation between CT scan suit to the operation theater with added much higher equipment cost in the relatively resource scarred developing country. Ultrasound-guided biopsy (USGB) is relatively simpler, economical, less time consuming, and real-time procedure. Clinical Materials and Methods: Thirty-seven consecutively admitted patients with supratentorial brain tumors, who underwent biopsy of the lesion using CT compatible stereotactic and ultrasound-guided (USGB) procedure formed cohort of the study. Based on location and size of the lesions, the cases were divided into two groups, superficial and deep. Twenty-two patients underwent ultrasound-guided biopsy and 15 with STB. Results: The diagnostic yield of STB was 93% and 91% for ultrasound-guided biopsy. The mean operation time of STB group was 149.00 min and 94 min for USGB, which was statistically significant. Two cases in each group developed hematoma; however, one case in USGB group needed surgical evacuation. The real-time monitoring detected two hematoma intraoperatively, which were further also confirmed on postoperative CT scan head. Conclusions: The ultrasound-guided biopsy procedure (USGB) was simple, relatively shorter time-consuming procedure and equally efficacious and utilizing economical equipment and can act as a safer alternative to CT STB process for biopsy of the intracranial mass lesion. Furthermore, USGB also provided intra-operative real-time monitoring, which provided clue for close monitoring in the postoperative period after completion of biopsy to look for development of fresh hematoma development not only at the biopsy site but also along the biopsy track and adjoining area. Perhaps, a longer period of ultrasonic monitoring following the procedure would be of greater help to detect hematoma formation, which is one of the most common complications of the biopsy procedure.