bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Vinylogous Carbinolamine Tumor Inhibitors. Part 25. Synthesis and Chemical Reactivity of C‐5 Substituted 6,7‐Bis(hydroxymethyl)‐1H‐pyrrolizine Biscarbamate Tumor Inhibitors.
Authors: ANDERSON W. K. , MACH R. H.
Published: May 2016

A series of C‐5 substituted pyrrolizine biscarbamate alkylating agents (III), (IV), (VI), (VII), (VIII) (likewise prepared starting from (I)) is synthesized and evaluated in an in vitro alkylation assay.
ChemInform Abstract: On the Reaction of N‐Vinyliminophosphoranes. Part 15. Synthesis and Spectroscopic Properties of 1‐Azamethanocyclopentacycloundecene Ring System.
Authors: NITTA M. , KANOMATA N. , TADA M.
Published: May 2016

The 3,8‐methano‐(11)annulenone (I) reacts with the iminophosphoranes (II) to give the fused pyrroles (III) and (IV).
ChemInform Abstract: Reaction of Polyfluorinated Copper(II) β‐Diketonates and β‐Ketoesterates with Hydrazine.
Authors: KONDRAT'EV P. N. , SKRYABINA Z. E. , SALOUTIN V. I. , PASHKEVICH K. I. , KLYUEV N. A. , ALEKSANDROV G. G.
Published: May 2016

The copper chelates (I) and (IV) are coupled with the hydrazine hydrochlorides (II) to give the pyrazoles (III) and (V) respectively.
ChemInform Abstract: Syntheses of Some 2‐Methyl‐3‐(p‐methoxy)cinnamoylchromones.
Authors: MAZUMDAR A. K. D. , DAS S. C. , SAHA G. C. , BANERJI K. D.
Published: May 2016

Condensation of the o‐hydroxyacetophenones (II) with p‐methoxycinnamic acid (I) yields the esters (III) which undergo pyridine‐catalyzed rearrangement to form the diketones (IV).
ChemInform Abstract: 2‐(Trifluoroacetyloxy)pyrydine as a Mild Trifluoroacetylating Reagent of Amines and Alcohols.
Authors: KEUMI T. , SHIMADA M. , MORITA T. , KITAJIMA H.
Published: May 2016

The new title compound (III) is a useful reagent for trifluoroacetylating a variety of amines such as (IV) and alcohols such as (VI).
ChemInform Abstract: Room Temperature Generation of Reactive Intermediates Cp*2Zr=O and Cp*2Zr=S: Trapping Reactions with Unsaturated Organic Molecules and Dative Ligands.
Authors: CARNEY M. J. , WALSH P. J. , BERGMAN R. G.
Published: May 2016

The title compounds (III) and (IX), obtained by deprotonation of their precursor complexes with a hindered base, are trapped by various unsaturated organic molecules and dative ligands as outlined in the scheme.
ChemInform Abstract: Reactivity of Hydroxo, Hydroperoxo and Peroxo Platinum(II) Derivatives Towards Carbon Oxides.
Authors: PORTA F. , RAGAINI F. , CENINI S. , SCIACOVELLI O. , CAMPOREALE M.
Published: May 2016

The reactions of the hydroperoxo complex (I), its phthalimide analogue, and the aryloxy analogues (VI) as well as of the hydroxo complex (VIII) and its phthalimide analogue with CO2 (II) and CO (IX) are studied.
ChemInform Abstract: Structure and Synthesis of the Metribuzin Blue Dye. Synthesis and Reactions of 2,5‐Dihydrazino‐1,3,4‐thiadiazole and Its Derivatives.
Authors: JACKMAN D. E.
Published: May 2016

A blue pigment which sometimes accompanies the manufacture of the triazine herbicide metribuzin (V) from the compounds (I) and (II) is identified as the novel thiadiazole formazan (IX) which arises from the reaction of two impurities (VIII) and (VII).
ChemInform Abstract: Synthesis of the Ketodifluoromethylene Dipeptide Isostere.
Authors: DAMON D. B. , HOOVER D. J.
Published: May 2016

The inhibition of aspartic proteases such as human renin and HIV protease is a pressing problem in bioorganic chemistry.
ChemInform Abstract: Stereospecific Friedel‐Crafts Alkylation of Benzene with 4‐Mesyloxy‐L‐prolines. A New Synthesis of 4‐Phenylprolines.
Authors: KRONENTHAL D. R. , MUELLER R. H. , KUESTER P. L. , KISSICK T. P. , JOHNSON E. J.
Published: May 2016

The trans‐hydroxyprolinate (I) is converted to the mesyloxy compound (IV), the chloro (V), or the fluoro derivative (VI).
ChemInform Abstract: Synthesis and Bioactivity of a New Class of Rigid Glutamate Analogues. Modulators of the N‐Methyl‐D‐aspartate Receptor.
Authors: KOZIKOWSKI A. P. , TUECKMANTEL W. + , REYNOLDS I. J. , WROBLEWSKI J. T.
Published: May 2016

Esterification of the dibromoglutaric acid (I) with benzyl alcohol (II) gives the dibenzyl ester (IIIc).
ChemInform Abstract: Cross Sections and Product Kinetic Energy Analysis of H2O+‐H2O Collisions at Suprathermal Energies.
Authors: LISHAWA C. R. , DRESSLER R. A. , GARDNER J. A. , SALTER R. H. , MURAD E.
Published: May 2016

The H2O+‐H2O reaction is studied at center‐of‐mass collision energies in the range 0.5‐25 eV.
ChemInform Abstract: MnGaScS4 and MnGa1.5Sc0.5S4, two New Compounds in the System MnGa2S4‐MnSc2S4.
Authors: HAEUSELER H. , STORK H. J.
Published: May 2016

XRD results obtained for quenched samples of the title system reveal the presence of two intermediate phases: a phase of composition MnGa2‐2xSc2xS4 (I) with 0.2 ≦ x ≦ 0.3 and the new olivine‐type compound MnGaScS4 (II) (i.e., x = 0.5), which exhibits no phase width.
ChemInform Abstract: Ternary Equiatomic Hafnium‐Transition Metal Silicides.
Authors: ZHAO J. T. , PARTHE E.
Published: May 2016

Samples of nominal composition HfMSi (M: Mn, Fe, Co, Ni, Mo, W, Re, Ru, Os, Rh, Ir, Pd, Pt) are prepared by arc melting under argon atmosphere and characterized by XRD.
ChemInform Abstract: Characterization of Silane‐Reduced Tungsten Films Grown by CVD as a Function of Si Content.
Authors: SUZUKI M. , KOBAYASHI N. , MUKAI K. , KONDO S.
Published: May 2016

The electrical resistivity, stress, and morphology of tungsten films on Si‐substrates, prepared by low pressure CVD using WF6/SiH4 gas mixtures, strongly depend on the Si content in the films.
ChemInform Abstract: Mass Effects on the Surface Reaction of Chlorine with Carbon.
Authors: PASQUEVICH D. M.
Published: May 2016

TGA results obtained for the reaction of carbon surfaces with Cl2 at 770 and 950 °C show that the mass of the carbon samples increases at a rate that increases with the mass.
ChemInform Abstract: The Oxidative Coupling of Methane on Mn/SiO2 and the Effect of Solidand Gas‐Phase Doping.
Authors: AHMED S. , MOFFAT J. B.
Published: May 2016

Li‐, Na‐, and K‐doped Mn/SiO2 catalysts show considerable activity and selectivity.
ChemInform Abstract: Morpholinoallenes by Conjugate Cuprate Addition to (2‐Propynylidene)morpholinium Triflates.
Authors: MAYER T. , MAAS G.
Published: May 2016

The iminium salt (I) reacts with the cuprates (II) in tetrahydrofuran to yield the propadienylmorpholines (III).
ChemInform Abstract: Effect of Micellar Medium on Photoanellation vs. Energy Transfer in the System Excited Cyclohex‐2‐en‐1‐one‐cyclopentadiene.
Authors: KUMAR M. S. , RAO J. M.
Published: May 2016

The photoreactions between cyclohex‐2‐en‐1‐one or its 4,4‐dimethyl derivative and cyclopentadiene afford mixtures of (4 + 2) and (2 + 2) cycloadducts and a new hydrocarbon C15H18.
ChemInform Abstract: gem.‐Difluorocyclopropanes Carrying Oxygen‐Functional Substituents.
Authors: SCHLOSSER M. , BESSARD Y.
Published: May 2016

Starting from the protected allyl alcohols (I) or (XI) the gem.‐difluorocyclopropyl alcohols (IV) and (XII) are prepared by addition of difluorocarbene and subsequent deprotection.
ChemInform Abstract: High‐Pressure Cycloaddition of Tropones to Ethoxyethene. An Occurrence of (4 + 2) and (8 + 2) Cycloadditions.
Authors: MORI A. , LI Z.‐H. , TAKESHITA H.
Published: May 2016

Cycloaddition of (I) and (VI) with (II) gives (4 + 2) and (8 + 2) cycloadducts.
ChemInform Abstract: Synthesis of 4‐Nitro‐3,3,7‐trimethyl‐2‐(2‐hydroxystyryl)indolenines.
Authors: PRZHIYALGOVSKAYA N. M. , MANAKOVA I. V. , KURKOVSKAYA L. N. , SUVOROV N. N.
Published: May 2016

The trimethylindolenine (III), prepared in situ from the nitrophenylhydrazine (I) and methyl isopropyl ketone (II), is coupled with the salicylaldehydes (IV) to give the 2‐styrylindolenines (V) in low yields.
ChemInform Abstract: Rearrangement of 1‐Acetylindoxyl Oxime into 1‐Acetyl‐2‐acetoxy‐3‐iminoindoline Hydrogen Sulfate.
Authors: VELEZHEVA V. S. , RYABOVA S. YU. , ALEKSEEVA L. M.
Published: May 2016

The indoxyl oxime (I) and its O‐acetyl derivative (VI) are coupled with acetic anhydride (II) and sulfuric acid to give the 2‐acetoxyindoles (III) and (VII) respectively.
ChemInform Abstract: Unexpected Formation of 3‐Substituted 4,6‐Dinitroanthranils During the Oxidation of Anionic σ‐Complexes of 1,3,5‐Trinitrobenzene.
Authors: KOVALENKO S. V. , ARTAMKINA G. A. , TERENT'EV P. B. , SHEVTSOV V. K. , BELETSKAYA I. P. , REUTOV O. A.
Published: May 2016

Oxidation of the trinitrobenzene σ‐complexes (I) with the system CCl4/ CuBr leads to the formation of the dinitroanthranils (II).
ChemInform Abstract: Synthesis of Silicon‐Containing Derivatives of 4‐Amino‐1,2,4‐triazole.
Authors: ABRAHAM W. , GLAENZEL A. + , BUCK K.
Published: May 2016

The 1‐silylmethyl derivatives (III) can be prepared from the aminotriazole (I).
ChemInform Abstract: N‐(α‐Lithioalkyl)tetrazoles and Their Reactions with Electrophiles.
Authors: MOODY C. J. , REES C. W. , YOUNG R. G.
Published: May 2016

Lithiation of the alkyltetrazoles (I) and (VIII) followed by reaction with the electrophiles (II), (IV), or (VI) yields the derivatives (III), (V), (VII), and (IX) respectively.
ChemInform Abstract: Synthesis of α‐Phenyldinicotinic Acid Derivatives and 2‐Phenyl‐3,5‐di‐(5‐phenyl‐2‐oxazolyl)pyridine.
Authors: PROSTAKOV N. S. , KIRILLOVA L. M. , KLYAVINA I. V. , ZAKHAROV P. I. , KHARLAMOVA M. D. , ALIEV A. E.
Published: May 2016

Starting with α‐phenyldinicotinic acid (I), the dichloride (II) and the amides (IV) are prepared.
ChemInform Abstract: Syntheses of Noncyclic Diamides with a Pyridine Ring Moiety and Their Transport Abilities for Transition Metal Ions.
Authors: DOHNO R. , OHOFUCHI S. , MIURA T. , KASEDA S. , HAKUSHI T.
Published: May 2016

Starting with diethylenetriamine (I), whose primary amino groups are blocked by formation of the bisazomethine (II), the diamides (VII) are synthesized as outlined in the reaction scheme.
ChemInform Abstract: Antiparasitic Agents. Part 13. Synthesis and Anthelmintic Activity of 6‐ and 8‐(2,4‐Dioxoquinazolin‐3‐yl)‐1‐substituted‐9H‐pyrido(3,4‐b)indoles, 6‐ and 8‐(2‐Methyl‐5‐acetamidobenzimidazol‐1‐yl)‐1‐substituted‐9H‐pyrido(3,4‐b)indoles and 6‐(2‐Carbomethoxyamino‐5‐(N,N′‐dicarbomethoxyguanidino)benzimidazol‐1‐yl)‐1‐phenyl‐9H‐pyrido(3,4‐b)indole.
Authors: AGARWAL A. , AGARWAL S. K. , BHAKUNI D. S. , GUPTA S. , KATIYAR J. C.
Published: May 2016

Positive anthelmintic effects are observed for (IIIb), (Vb), (XI) and (XIV) with the latter compound being the most active one.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition Reactions of Ylides Formed from Pyridines and Dichlorocarbene.
Authors: KHLEBNIKOV A. F. , KOSTIK E. I. , KOSTIKOV R. R. , BESPALOV V. YA.
Published: May 2016

Reaction of the pyridines (I) or (V) with dichlorocarbene, generated in situ from chloroform (II), and dimethyl maleate (III) followed by oxidation gives the indolizines (IV) or (VI) and (VII).
ChemInform Abstract: Synthesis of 5‐Hydroxyalkyl‐ and 5‐Alkenyl‐1,3‐dioxanes.
Authors: ZLOTSKII S. S. , LESNIKOVA E. T. , RAKHMANKULOV D. L. , TIMPE H.‐J.
Published: May 2016

Products of reduction (→ (II)), Grignard reaction (→ (VI)), and Wittig reaction (→ (X)) of the dioxane substrates (I) are synthesized.
ChemInform Abstract: Unexpected Routes to Naphthoporphyrin Derivatives.
Authors: CALLOT H. J. , SCHAEFFER E. , CROMER R. , METZ F.
Published: May 2016

Treatment of the styrylcobalt(III)porphyrin (I) with < 5·103 moles of TFA per mole of porphyrin unexpectedly affords the naphthoporphyrins (II) and (III) along with the expected "normal" product, i.e. demetalated (I).
ChemInform Abstract: Tricyclic Oxonium‐Directed Addition: Regiochemistry and Stereochemistry of the Iodination Reactions of 2,3‐Epoxycyclooct‐5‐en‐1‐ols and 2,3‐Epoxy‐5‐en‐1‐one.
Authors: ALVAREZ E. , DIAZ M. T. , RODRIGUEZ M. L. , MARTIN J. D.
Published: May 2016

The known cyclooctadienol (I) is epoxidized under different conditions, yielding mixtures of the cis‐ (II) and trans‐epoxycyclooctenols (III) with predominance of the former.
ChemInform Abstract: Synthesis and Characterization of Monosubstituted Borane Adducts of Diethyl ((Dimethylamino)methyl)phosphonate.
Authors: MITTAKANTI M. , CHARANDABI M. R. M. D. , MORSE K. W.
Published: May 2016

The borane adducts (III), (IV), (V), (VI), and (VII) are synthesized as shown starting with the cyanoborane adduct (I).
ChemInform Abstract: Phosphorus‐Nitrogen Compounds. Part 64. The Reactions of Hexachlorocyclotriphosphazatriene with 2,2‐Dimethylpropane‐1,3‐diol. Nuclear Magnetic Resonance Studies of the Products.
Authors: AL‐MADFA H. A. , SHAW R. A. , TURE S.
Published: May 2016

Product types and relative yields are compared with those arising from propane‐1,3‐diol.
ChemInform Abstract: A New Type of Metal‐Olefin Complex. Synthesis and Characterization of Four Compounds That Contain an Ethylene Bridge Perpendicularly Bisecting a Metal‐Metal Axis.
Authors: COTTON F. A. , KIBALA P. A.
Published: May 2016

The edged‐sharing bioctahedral dimers Zr2X6(PEt3)4 prepared by reduction of ZrX4 (I) in the presence of PEt3 (II) readily reacts with 1,2‐dichloroethane (III) to give the metal‐olefin complexes (IVa) (space group Pbca, Z=4) and (IVb) ( P21/n, Z=2) of a novel type.
ChemInform Abstract: Carbonyliron Complexes of Allenic Acids, Esters, Amides, and Imides.
Authors: TRIFONOV L. S. , ORAHOVATS A. S. , HEIMGARTNER H.
Published: May 2016

On irradiation in the presence of Fe(CO)5, the allenic amide (V) and imide (VII) show a similar course of complexation to that of esters and lactones.
ChemInform Abstract: Preparations and Structures of Two Polynuclear Aggregates Obtained by Using the Metallaligand (ClAuPPh2CH2)2AsPh.
Authors: BALCH A. L. , FUNG E. Y. , OLMSTEAD M. M.
Published: May 2016

The polynuclear compounds (III) (space group P21/n, Z=4) and (VI) (P1, Z=4) are synthesized and characterized by X‐ray analysis.
ChemInform Abstract: A Novel Slipped Tripledecker Complex with a 3,4‐Diborafulvene as Bridging Ligand.
Authors: HERBERICH G. E. , GANTER C. , WESEMANN L. , BOESE R.
Published: May 2016

X‐Ray structure analysis of the tripledecker complex (III) (space group P21/c, Z=4) confirms that one (cod)Rh fragment is η5‐bonded and the second (cod)Rh fragment is η4‐bonded to the exocyclic CH2 group and to the three C atoms of the ring resembling a trimethylenemethane complex.
ChemInform Abstract: Synthesis of the 6‐C‐Methyl and 6‐C‐(Hydroxymethyl) Analogues of N‐Acetylneuraminic Acid and of N‐Acetyl‐2,3‐didehydro‐2‐deoxyneuraminic Acid.
Authors: VASELLA A. , WYLER R.
Published: May 2016

To study the effect of substituents on the upper side of the pyranose ring of sialic acids upon the inhibition of neuraminidases, the C2‐branched derivatives (Ib), (IIb) and (IIc) of N‐acetylneuraminic acid (Ia) and its 2,3‐didehydro‐2‐deoxy derivative (IIa) are prepared possessing non‐polar methyl and polar hydroxymethyl groups.
ChemInform Abstract: Cytotoxic Cyclitols. Synthesis of Ethanolamino and Haloethylamino Derivatives of Methylsulfonylated Cyclitols.
Authors: CADENAS R. A. , ELIAS C. , GELPI M. E.
Published: May 2016

The mesylated inosamine hydrochloride (IV) prepared from the protected cyclitol (I) as outlined in the reaction scheme reacts with ethylene oxide (V) to give the diethanolamino derivative (VI).
ChemInform Abstract: Synthesis of Isoquinoline Precursors by Photoamination of Stilbenes with Bifunctional Alkylamines.
Authors: YASUDA M. , KUBO J. , SHIMA K.
Published: May 2016

The N‐substituted diarylethylamines (III) are prepared by photochemical reaction of the stilbenes (I) with the primary amines (II).
ChemInform Abstract: Synthesis of the Potent Antiviral Oxetane Nucleoside Epinoroxetanocin from D‐Lyxonolactone.
Authors: WANG Y. , FLEET G. W. J. , STORER R. , MYERS P. L. , WALLIS C. J. , DOHERTY O. , WATKIN D. J. , VOGT K. , WITTY D. R. , WILSON F. X. , PEACH J. M.
Published: May 2016

Besides the synthesis of the title compound (IX) from D‐lyxonolactone (I) via the intermediate (VIII) (X‐ray structure, but no data given), a brief comparison of its in vitro activity against HIV‐1 with those of oxetanocin (Xa) and noroxetanocin (Xb) is presented.
ChemInform Abstract: The Total Synthesis of Desferrioxamines E (VI) and G (V).
Authors: BERGERON R. J. , MCMANIS J. S.
Published: May 2016

The title compounds are therapeutic iron chelators.
ChemInform Abstract: Characterization of Synthetic Diamond Thin Films.
Authors: RAMESHAM R. , ROPPEL T. , ELLIS C. , HAJEK B. F.
Published: May 2016

Free‐standing diamond thin films and as‐deposited thin films on a Si substrate, prepared by high‐pressure, microwave plasma assisted chemical vapor deposition from a CH4/H2 mixture, are analyzed by SEM, Raman spectroscopy, and XRD.
ChemInform Abstract: Electronmicroscopic Investigations on Disordered Crystals of O‐LaTa3O9, M‐CeTa3O9, and M2‐PrTa3O9 ‐ Proof of a New M1‐CeTa3O9 Modification.
Authors: STEINMANN G. , GRUEHN R. , LANGENBACH‐KUTTERT B.
Published: May 2016

On the basis of the high resolution electron microscopic results, structural imperfections within orthorhombic O‐LaTa3O9 (space group Pnma, Z=4) and monoclinic M2‐PrTa3O9 (P21/m, Z=2) are discussed.
ChemInform Abstract: BaCu8P4 and BaCu8As4: Preparation, Structure Determination, and HRTEM Investigations.
Authors: PILCHOWSKI I. , MEWIS A. , WENZEL M. , GRUEHN R.
Published: May 2016

Single crystals of the title compounds are obtained from reactions of the elements at 1200 °C (slight excess of Ba, sealed quarz‐ampoule, argon).
ChemInform Abstract: Structure of a New Modification of Phosphorus Sulfide P4S9.
Authors: WALLIS B. , WOLF G.‐U. , LEIBNITZ P.
Published: May 2016

A new modification of P4S9, denoted as P4S9‐III, is obtained besides P4S9‐I from the reaction of P4S10 with iPrOH (1:4 molar ratio) and isolated by repeated fractional crystallization from CS2.
ChemInform Abstract: A New Carbonat‐Analogous Oxocobaltate(II): RbNa7(CoO3)2.
Authors: BIRX J. , HOPPE R.
Published: May 2016

The title compound (III) crystallizes in the monoclinic space group C2/m with Z=2.
ChemInform Abstract: Incremental Preorganization of a Chelating Macrocycle.
Authors: DESPER J. M. , GELLMAN S. H.
Published: May 2016

Conformations and Ni(II)‐chelation efficacies are studied in the series (I)‐(II)‐(III).
ChemInform Abstract: Solid‐State Conformations of Medium‐Sized‐Ring Phosphorus Heterocycles: X‐Ray Crystal Structures of Two Norbornene‐Fused 1,3,2‐Dioxaphosphepanes with Equatorially Disposed Substituents on Phosphorus.
Authors: SETZER W. N. , BROWN M. L. , ARIF A. , VANDERVEER D. G.
Published: May 2016

The seven‐membered‐ring phosphorus heterocycles (Ia) (space group P21/c, Z=4) and (Ib) (P212121, Z=4) are synthesized by equimolar reaction of 5‐norbornene‐endo,endo‐2,3‐dimethanol with phenyl dichlorophosphate or phenylphosphonic dichloride in the presence of NEt3 as diastereomeric mixtures with their cis isomers and separated by preparative HPLC.
ChemInform Abstract: Phosphato Complexes of Platinum(II): 31P NMR and Kinetics of Formation and Isomerization Studies.
Authors: BOSE R. N. , GOSWAMI N. , MOGHADDAS S.
Published: May 2016

Ortho‐, pyro‐ and triphosphate anions form monodentate complexes with chloro(diethylenetriamine)platinum(II) chloride and various chelates with PtCl2(en) in the pH range 2‐11. Rate constants for these reactions are determined and the various phosphate complexes are characterized by 31P NMR spectroscopy.
ChemInform Abstract: Novel Generation and Regio‐ and Stereospecific 1,3‐Dipolar Cycloaddition of 2‐Ethoxycarbonyl‐3,3‐dimethyl‐3H‐indolium 1‐Methanide.
Authors: FISHWICK C. W. G. , JONES A. D. , MITCHELL M. B. , EGGLESTON D. S. , BAURES P. W.
Published: May 2016

Reaction of the 3H‐indole (I) with trimethylsilylmethyl triflate (II) and the electron deficient dipolarophiles (III), (V), or (VII) results in cyclization to produce the fused dihydroindoles (IV), (VI), and (VIII) respectively.
ChemInform Abstract: Tin‐Directed Baeyer‐Villiger and Beckmann Fragmentations.
Authors: BAKALE R. P. , SCIALDONE M. A. , JOHNSON C. R.
Published: May 2016

An examination is reported of the β‐effect of tin to direct C‐C bond fragmentations that were both efficient and compatible with multiple functionalities.
ChemInform Abstract: Corner Attack on Cyclopropane by Thallium(III) Ions. A Highly Stereospecific Cleavage and Skeletal Rearrangement of 3α,5‐Cyclo‐5α‐cholestan‐6α‐ol.
Authors: KOCOVSKY P. , POUR M. , GOGOLL A. , HANUS V. , SMRCINA M.
Published: May 2016

Evidence is presented for stereospecific corner attack at the cyclopropane ring of model compound (Ia) by Tl(III) leading to (IIa) via a double‐inversion pathway.
ChemInform Abstract: Acid‐Catalyzed (3,3)‐Sigmatropic Rearrangements of N‐Propargylanilines.
Authors: BARMETTLER P. , HANSEN H.‐J.
Published: May 2016

Fourty‐four title compounds are investigated.
ChemInform Abstract: A Convenient Synthesis of 3‐(1,3‐Alkadienyl)‐2‐cycloalken‐1‐ones.
Authors: LU X. , GUO C. , MA D.
Published: May 2016

Ru(II)‐catalyzed isomerization of the alkynylcycloalkenones (I) in benzene yields the alkadienylcycloalkenones (II).
ChemInform Abstract: 1,2‐ and 1,4‐Stereoinduction in Reactions of Chiral Radicals.
Authors: GIESE B. , ZEHNDER M. , ROTH M. , ZEITZ H.‐G.
Published: May 2016

It is shown that the atom abstraction by the chiral radical (III), which is formed in the radical chain reaction of the fumaramide (I) with the tert.‐butyl radical, occurs also stereoselectively leading to the final products (IVa) + (IVb).
ChemInform Abstract: Coupling of Allenes and Carbon Dioxide Catalyzed by Electrogenerated Nickel Complexes.
Authors: DERIEN S. , CLINET J.‐C. , DUNACH E. , PERICHON J.
Published: May 2016

Electrolysis of the allenes (I) and (V) in a carbon dioxide atmosphere under pressure and in the presence of a Ni(II) complex results in reductive carboxylation, forming predominantly the unsaturated carboxylic acids (III) and (IV) or (VI) and (VII).
ChemInform Abstract: Lewis Acid‐Mediated Addition of Lithiated Alkyl Phenyl Sulfones and Oxiranes. A Method for Synthesis of α,β‐Unsaturated Ketones.
Authors: MARCZAK S. , WICHA J.
Published: May 2016

Reaction of the phenyl sulfones (I) with the epoxides (II) after treatment with a base results in cleavage of the oxirane ring, forming the γ‐hydroxy sulfones (III).
ChemInform Abstract: Direct Oxidation of 1‐Naphthaldehydes to 2‐Substituted 1,4‐Naphthoquinones: Application to the Chemoselective Syntheses of Pyrano‐ and Furano‐1,2‐naphthoquinones.
Authors: GUPTA R. B. , FRANCK R. W.
Published: May 2016

Cycloaddition reaction of the isoquinolinium chloride (I) with the vinyl ethers (II) followed by acid‐catalyzed cleavage of the intermediates (IV) yields the aromatic aldehydes (V) and (VII) which are transformed into the 1,4‐naphthoquinones (VI), (VIII), (IX), and (X).
ChemInform Abstract: Synthesis and Photoreactions of Some Spiro(cycloalkanephenalenes).
Authors: HEMPENIUS M. A. , LUGTENBURG J. , CORNELISSE J.
Published: May 2016

The reaction of the phenalenyl anion with dibromoalkanes leads to the tetrahydropyrenes (III) and (IV) or to the title spiro compounds (VI) which show different behavior on irradiation.
ChemInform Abstract: Formation, Synthetic Utility, and Structure Elucidation of a 2‐Bromomethyl‐1,4‐dihydropyridine.
Authors: ALKER D. , SWANSON A. G.
Published: May 2016

The dihydropyridine (I) reacts with pyridinium tribromide to give mainly the monobromomethyl derivative (II) which is coupled with the compounds (III) to form the substitution products (IV).
ChemInform Abstract: Macro‐Rings Designed for Uncharged Molecule Complexation. Synthesis, Complex Formation, and Structural Studies of New Pyridino Crowns (I) and (II) Incorporating Resorcinol and Hydroquinone Building Blocks. X‐Ray Crystal and Molecular Structure of a 22‐Membered Pyridino Crown (III).
Authors: WEBER E. , KOEHLER H.‐J. + , PANNEERSELVAM K. , CHACKO K. K.
Published: May 2016

Crystal structure analysis of the pyridino crown (III) (space group P1, Z=4) reveals that two independent molecules with different conformations are present in the crystal having steric factors highly unfavourable for complex formation.
ChemInform Abstract: Phosphorochloridate and Dichlorothioate Ions: Aprotic Access and Evidence for Chloride Ion Release to Form Metaphosphate Type Intermediates.
Authors: TEICHMANN H. , SCHULZ J.
Published: May 2016

Monomeric, non‐coordinated salts of the dichlorophosphoric, dichlorophosphorothioic and dithioic acid (III) and (IV) are obtained in high yields by dealkylation of the corresponding methyl esters (I) using quaternary ammonium (II) or phosphonium halides.
ChemInform Abstract: Oxidative Detoxification of Phosphonothiolates.
Authors: YANG Y.‐C. , SZAFRANIEC L. L. , BEAUDRY W. T. , ROHRBAUGH D. K.
Published: May 2016

The chemical nerve agent (I) is an unusually selective oxidation substrate.
ChemInform Abstract: A Convenient Synthesis of Alkyl and Dialkyl 1‐Benzyloxyamino Alkyl Phosphonates and Phosphinates.
Authors: ELHADDADI M. , JACQUIER R. , GASTAL F. , PETRUS C. , PETRUS F.
Published: May 2016

The title compounds (III), (IV) and (VI) are prepared by an easy and general pathway.
ChemInform Abstract: Photolysis of Diphosphonate Derivatives Having Aromatic Ring Assemblies.
Authors: SHI M. , OKAMOTO Y. , TAKAMUKU S.
Published: May 2016

By this reaction the formation of (III), (IV) and (VI) is observed.
ChemInform Abstract: Water‐Soluble Metal Complexes and Catalysts. Part 4. 2,2′‐Bipyridine‐5‐sulfonic Acid: Synthesis, Purification, Derivatives and Metal Complexes.
Authors: HERRMANN W. A. , THIEL W. R. , KUCHLER J. G.
Published: May 2016

The title compound (II) is prepared by Hg(II)‐catalyzed sulfonation shown in the scheme and converted into its salts (III) and into the sulfonamides (V).
ChemInform Abstract: Selective Lithium Encapsulation in Aqueous Solution by the New Cage 4,10‐Dimethyl‐1,4,7,10,15‐pentaazabicyclo(5.5.5)heptadecane (L). Synthesis, Characterization, and Structural Aspects. Crystal Structures of (LiL)(ClO4) and (CuL)Br2·3 H2O.
Authors: BENCINI A. , BIANCHI A. , BORSELLI A. , CHIMICHI S. , CIAMPOLINI M. , DAPPORTO P. , MICHELONI M. , NARDI N. , PAOLI P. , VALTANCOLI B.
Published: May 2016

Small cations can be encapsulated into the cavities of rather rigid macrobicyclic cages with a high degree of selectivity.
ChemInform Abstract: Alkoxystannates. Part 4. Preparation and Structure of Alkali Penta‐tert.‐butoxystannates(IV).
Authors: VEITH M. , REIMERS M.
Published: May 2016

In contrast to lithium and sodium tert.‐butoxide the alkali metal tert.‐butoxides (II) form the title stannates (III), which are soluble in non‐coordinating solvents and seem to be monomeric.
ChemInform Abstract: Synthesis, Physical Properties and X‐Ray Crystal Structure of an Oxovanadium(IV) Complex of the Pendant‐Arm Macrocycle 6,13‐Dimethyl‐1,4,8,11‐tetra‐azacyclotetradecane‐6,13‐diamine.
Authors: BERNHARDT P. V. , LAWRANCE G. A. , COMBA P. , MARTIN L. L. , HAMBLEY T. W.
Published: May 2016

In the title complex (III) (space group C2/c with Z = 8) the ligand coordinates in a quinquedentate manner.
ChemInform Abstract: Synthesis and Reactions of Tungsten(IV) Bis(imido) Complexes: Relatives of Bent Metallocenes.
Authors: WILLIAMS D. S. , SCHOFIELD M. H. , ANHAUS J. T. , SCHROCK R. R.
Published: May 2016

A complex type (III), containing other tertiary phosphines or phosphites, so far are not isolated.
ChemInform Abstract: Copper(II) and Nickel(II) Complexes of N,N′,N′′,N′′′‐Tetrakis(2‐aminoethyl)‐1,4,7,11‐tetraazacyclotetradecane (taei), ‐1,4,8,12‐tetraazacyclopentadecane (taep), and ‐1,5,9,13‐tetraazacyclohexadecane (taeh). Crystal Structures of (Cu2(taep))(ClO4)4, (Cu2(taeh))(ClO4)4, and (Cu2(N3)(taeh))(ClO4)3.
Authors: MURASE I. , UEDA I. , MARUBAYASHI N. , KIDA S. , MATSUMOTO N. , KUDO M. , TOYOHARA M. , HIATE K. , MIKURIYA M.
Published: May 2016

The new octamine dinucleating ligands (I) are synthesized by a known method reacting the parent tetraazamacrocycles with N‐tosylaziridine in refluxing acetonitrile, followed by treatment with HBr/acetic acid.
ChemInform Abstract: Gold Complexes with Selenium Ligands. Part 1. Preparation and Crystal Structures of Phenylselenolato‐Gold(I) Complexes.
Authors: JONES P. G. , THOENE C. +
Published: May 2016

The phenylselenolato‐Au(I) complexes (III) (space group P1, Z=4) and (VII) as well as the phenylselenolate‐bridged binuclear complex (V) (Pbca, Z = 8) are obtained as shown.
ChemInform Abstract: Bis(η6‐hexamethylbenzene)(η6,η6‐polycyclic aromatic)diruthenium(II,II) Complexes and Their Two‐Electron Reduction to Cyclohexadienyl Anion Complexes.
Authors: PLITZKO K.‐D. , WEHRLE G. , GOLLAS B. , RAPKO B. , DANNHEIM J. , BOEKELHEIDE V.
Published: May 2016

Similar to (III), the complexes (VI) and (VII) and the same type containing tetramethyl‐substituted biphenyl, 4,5,9,10‐tetrahydropyrene, pyrene or triphenylene are synthesized, and their electrochemical properties are investigated.
ChemInform Abstract: Aqueous Chemistry of Platinum and Palladium Complexes. Part 2. Synthesis and Crystal Structure of a Palladium Hydroxo Complex (Pd(terpy)(OH))ClO4·H2O (terpy: 2,2′:6′,2′′‐terpyridine).
Authors: CASTAN P. , DAHAN F. , WIMMER S. , WIMMER F. L.
Published: May 2016

The complex (III) can also be obtained by metathesis of the corresponding chloro derivative with AgNO3.
ChemInform Abstract: Photoelectrochemical (PEC) Properties of Bismuth Oxyhalide Films.
Authors: POZNYAK S. K. , KULAK A. I.
Published: May 2016

BiOX (X: Cl, Br, I) electrodes prepared by anodic oxidation of Bi films on a Pt substrate are shown to exhibit PEC properties characteristic for p‐type semiconductors in acidified KX solutions.
ChemInform Abstract: The Generation of 2,3‐Dihydro‐2,3‐bis(methylene)thiophenes from 4,6‐Dihydrothieno(3,4‐b)thiophene 5,5‐Dioxides.
Authors: CREW A. P. A. , JENKINS G. , STORR R. C. , YELLAND M.
Published: May 2016

Heating of the dihydrothienothiophene dioxides (I) in sulfolane up to 200°C yields the intermediates (II) which in situ undergoes Diels‐Alder reaction with the dienophiles (III), (V), and (VII) to give the cycloadducts (IV), (±)‐(VI), and (VIII) respectively.
ChemInform Abstract: Flash Photolysis of (η3‐N‐diene)W(CO)4 (N‐diene: trans‐2‐Methyl‐2‐aza‐5,7‐octadiene) in Triethylsilane: Regioselective 1,2‐Hydrosilylation.
Authors: WANG I‐H. , DOBSON G. R. , JONES P. R.
Published: May 2016

Flash photolysis of the synthesized title complex (III) in chlorobenzene gives rise to an intermediate in which the rapidly solvated, coordinatively unsaturated site is cis to the coordinated internal olefin.
ChemInform Abstract: Studies of Reduction with Dimethoxyborane‐Transition Metal Boride Systems.
Authors: NOSE A. , KUDO T.
Published: May 2016

The system nickel boride/dimethoxyborane is successfully employed in the reduction of the aldehydes (I), the methyl ketones (III), trans‐stilbene (V), and the nitriles (VII).
ChemInform Abstract: α‐(Methylthio)benzyl Sulfones as Synthetic Intermediates. Part 4. Some New o‐, m‐, and p‐Substituted α‐(Methylthio)‐ and α,α′‐Bis(methylthio)benzyl Sulfones.
Authors: WLADISLAW B. , MARZORATI L. , EBELING G.
Published: May 2016

The m‐ and p‐substituted benzyl sulfones (I) react with S‐methyl methanethiosulfonate (II) under phase‐transfer conditions to form the α,α'‐bissulfenylated derivatives (III).
ChemInform Abstract: 1,3‐Dipolar Cycloaddition Reaction of 4‐Benzylideneoxazolones with Diphenylnitrilimine.
Authors: BABA N. , SOUFIAOUI M.
Published: May 2016

The title nitrilimine, generated from the hydrazonoyl chloride (I), reacts with the benzylideneoxazolones (II) to form the spiro compounds (III) and the dihydropyrazolecarboxylic acids (IV) depending on the reaction conditions.
ChemInform Abstract: Activated Nitriles in Heterocyclic Synthesis: Novel Synthesis of Pyrrolo(1,2‐c)imidazole and Pyrano(2,3‐d)imidazole Derivatives.
Authors: ABDELAZIZ M. A. , MOHARRAM H. H. , ESSAWY S. A. , MOHAMED A. A.
Published: May 2016

Cyclocondensation of the furanyl‐ and thienylacrylonitrile derivatives (I) with 2‐thiohydantoin (II) gives the pyrrolo(2,3‐c)imidazole derivatives (III) which are also obtained by consecutive reaction of the cyanoacrylates (IV) with (II) and malononitrile (VI) via the adducts (V).
ChemInform Abstract: Hetarylation with N‐Methoxycarbonyl‐ and N,N‐Dialkyl(aryl)carbamoylbenzopyridinium Salts in situ.
Authors: SHEINKMAN A. K. , FEDASH E. V. , CHMILENKO T. S. , ORLOV S. I.
Published: May 2016

Simultaneous coupling of isoquinoline (I) with the chloroformate (IIa) or the carbamic chlorides (IIb) ‐ (IIe) and indole (III) gives the dihydroisoquinolines (IV).
ChemInform Abstract: Activated Nitriles in Heterocyclic Synthesis: Novel Synthesis of Pyridine, Benzo(1,4)thiazine, and Benzo(1,3)thiazole Derivatives.
Authors: ELGEMEIE G. E. H. , ELGHANDOUR A. H. H.
Published: May 2016

The α,β‐unsaturated nitriles (II), (IV), and (VI) react with 2‐aminobenzenethiol (I) to form the pyridine (III), the 1,4‐benzothiazine (V), and the benzothiazole derivatives (VII) respectively.
ChemInform Abstract: Synthesis of Homochiral Unsaturated Seven‐Membered Lactams.
Authors: EVANS P. A. , HOLMES A. B. , RUSSELL K.
Published: May 2016

The title compound (VIII) is prepared via Claisen rearrangement of an intermediate ketene aminal derived from the aminal (VI).
ChemInform Abstract: Synthetic Experiments Aiming at 1,2,4,5‐Tetrahydro‐3‐benzothiepin Derivatives.
Authors: VEJDELEK Z. , PROTIVA M.
Published: May 2016

Treatment of the title compound (III) with methyl iodide results unexpectedly in formation of the methiodide (V) (yield given in g) with concomitant loss of the phenyl group.
ChemInform Abstract: Selective Cleavage of t‐Butyldiphenylsilyl Ethers in the Presence of t‐Butyldimethylsilyl Ethers.
Authors: SHEKHANI M. S. , KHAN K. M. , MAHMOOD K. , SHAH P. M. , MALIK S.
Published: May 2016

The triol (Ia) is converted to the asymmetric bissilyl ethers (Ib) or (Id) which are selectively cleaved to produce the monoethers (Ic) and (Ie) respectively.
ChemInform Abstract: Gas‐Phase Heteroaromatic Substitution. Part 9. Silylation of Simple Five‐Membered Heteroaromatic Rings by Trimethylsilyl Cations.
Authors: CRESTONI M. E. , FORNARINI S. , SPERANZA M.
Published: May 2016

The reactions of the trimethylsilyl cation, obtained in the gas phase from the γ‐radiolysis of CH4/(CH3)4Si mixtures, with pyrrole, N‐methylpyrrole, furan, and thiophene, both neat and in competition in toluene, at 620‐720 torr and in the presence of variable concentration of gaseous NEt3 (0‐10 torr) are investigated.
ChemInform Abstract: Organic Chemistry in Water. Part 5. Nucleophilic Addition of Water‐Soluble Phosphines on Activated Alkynes: An Efficient Synthesis of New Vinylphosphonium Salts and of Specifically Deuterated Olefins.
Authors: LARPENT C. , MEIGNAN G. , PATIN H.
Published: May 2016

The hydrophilic phosphines (I) and (V) react in water with a variety of activated alkynes (9 examples given with tabulated results) affording new vinylphosphonium salts or vinylphosphine oxides as demonstrated for the examples in the scheme.
ChemInform Abstract: Heterocycles as Ligands. Part 9. 2,3,4,5‐Tetramethyl‐1‐sodiopyrrole: An Azacyclopentadienyl Ligand with a Novel Bridge‐Function.
Authors: KUHN N. , HENKEL G. , KREUTZBERG J.
Published: May 2016

The reaction of NaH with 2,3,4,5‐tetramethylpyrrole in THF at reflux yields with 43% yield the polymeric title compound.
ChemInform Abstract: Organo‐Transition‐Metal Complexes of Multidentate Ligands. Part 13. Is AgNO3 a Nitrosation Reagent?
Authors: SHIU K.‐B. , CHANG C.‐J.
Published: May 2016

Ag nitrate reacts at room temp. within minutes with the tricarbonyl complexes (I) to give cationic nitrosyldicarbonyl products which are isolated as their salts (II).
ChemInform Abstract: Synthesis and Characterization of ((2,4,6‐(CH3O)3C6H2)3P=O)FeCl3: A Four‐Coordinate Phosphine Oxide Adduct of FeCl3.
Authors: DUNBAR K. R. , HAEFNER S. C. , QUILLEVERE A.
Published: May 2016

The 1:1 molar reaction between FeCl3 (I) and the phosphine (II) leads to a reactive 1:1 adduct.
ChemInform Abstract: Chemistry of Silicon‐Sulfur Compounds. Part 57. Synthesis, Molecular Structure and Properties of Cyclo‐tetrakis(tri‐tert.‐butoxysilanethiolatocopper(I)), ((t‐C4H9O)3SiSCu)4, the First Example of a Square Planar Cu4S4 Ring.
Authors: BECKER B. , WOJNOWSKI W. , PETERS K. , PETERS E.‐M. , VON SCHNERING H. G.
Published: May 2016

The tetrameric title compound (III) (space group C2/c, Z=4) is obtained from the silanethiol (I) and Cu2O (II) or CuCl or Cu(II) acetate and characterized by X‐ray structure analysis and spectroscopic (UV, IR, NMR, MS) data.
ChemInform Abstract: The Stereoselective Reaction of Sodium Cyanide with the Cationic Ruthenium Vinylidene Complex ((η5‐C5H5)(PMe3)2Ru=C=C(Me)Ph)+.
Authors: DAVIES S. G. , SMALLRIDGE A. J.
Published: May 2016

The Z isomer (III) is stereoselectively formed in the title reaction.
ChemInform Abstract: Synthesis of a New Heterobinuclear Iron‐Ruthenium Complex, Cyclic (CO)3Fe(.mu±eta.4‐C(O)C(Ph)=C=CH2)Ru(CO)Cp, and Its Reactions to Give Trinuclear Metal Clusters.
Authors: SHUCHART C. E. , YOUNG G. H. , WOJCICKI A. , CALLIGARIS M. , NARDIN G.
Published: May 2016

The new ruthenium‐propargyl complex (I) (preparation described) reacts with Fe2(CO)9 to give the title complex (III) (P21/c, Z = 8), whereas the iron‐propargyl analogue gives (VII) (P1, Z=2) in a similar reaction.
ChemInform Abstract: Cyclometallated Compounds. Part 5. Double Cyclopalladation of Diphenyl Pyrazines and Related Ligands.
Authors: STEEL P. J. , CAYGILL G. B.
Published: May 2016

As shown for the case of the diphenylpyrazine (I), the choice of reaction conditions provides mono‐ or di‐cyclopalladated products (IV) or (VI) (P21/c, Z=4).
ChemInform Abstract: Coordination Chemistry of Iminooxosulfuranes. Part 8. The Coupling of Tosyliminooxosulfurane with Ethylene, Allene, and Alkynes Coordinated to Osmium.
Authors: HERBERHOLD M. , HILL A. F.
Published: May 2016

The reactions of zerovalent Os nitrosyl complexes OsCl(NO)(PPh3)2L (L: CH2=CH2, CH2=C=CH2, PhC≡CH, PhC≡CPh, MeC≡CMe, CF3C≡CCF3) with the title iminooxosulfurane (II) are investigated and mechanisms are discussed.
ChemInform Abstract: Stereoselective Syntheses of α‐Isosparteine.
Authors: OINUMA H. , DAN S. , KAKISAWA H.
Published: May 2016

The title compound (V), known to decrease the concentration of cholesterol in the blood, is prepared in a stereospecific manner using two different pathways starting from the nitrone (I).
ChemInform Abstract: Studies on Penem and Carbapenem. Part 1. Syntheses and Oral Absorption of Ester‐Type Prodrugs of Sodium (5R,6S)‐2‐(2‐Fluoroethylthio)‐6‐((1R)‐1‐hydroxyethyl)penem‐3‐carboxylate.
Authors: MIYAUCHI M. , ENDO R. , WATANABE K. , KAWAHARA Y. , IWATA M. , KAWAMOTO I.
Published: May 2016

Treatment of the sodium penemcarboxylate (I) with the acyloxyalkyl halides (II) or (IV) yields the esters (III) and (V) respectively which show enhanced oral absorption in mice in comparison to (I).
ChemInform Abstract: Rare Earth Elements as Components of Special Glasses
Authors: LACZKA M. , STOCH L.
Published: May 2016

Review: (synthesis, structure, and properties of special glasses such as optical glasses, optical filters for UV and visible light, luminescent glasses and laser glasses.
On the set‐theoretic strength of the existence of disjoint cofinal sets in posets without maximal elements
Authors: Howard Paul , Saveliev Denis I. , Tachtsis Eleftherios
Published: May 2016

In set theory without the Axiom of Choice , we study the deductive strength of the statements (“Every partially ordered set without a maximal element has two disjoint cofinal subsets”), (“Every partially ordered set without a maximal element has a countably infinite disjoint family of cofinal subsets”), (“Every linearly ordered set without a maximum element has two disjoint cofinal subsets”), and (“Every linearly ordered set without a maximum element has a countably infinite disjoint family of cofinal subsets”).
Among various results, we prove that none of the above statements is provable without using some form of choice, is equivalent to , + (Dependent Choices) implies , does not imply in (Zermelo‐Fraenkel set theory with the Axiom of Extensionality modified in order to allow the existence of atoms), does not imply in (Zermelo‐Fraenkel set theory minus ) and (hence, ) is strictly weaker than in .
Erratum: Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle
Authors: Parker Darren J. , Cunningham Christopher B. , Walling Craig A. , Stamper Clare E. , Head Megan L. , Roy-Zokan Eileen M. , McKinney Elizabeth C. , Ritchie Michael G. , Moore Allen J.
Published: May 2016

Nature Communications 6, Article number: 8449 (2015); Published: 29 September 2015; Updated: 27 May 2016 In the Methods section of this Article, a detail of the analysis involved in producing Fig. 4 and Table 2 was omitted. The section ‘Mapping and detection of differential expression’ should state that the overall magnitude of gene expression change was examined, ignoring the direction (up or downregulation).
Correction: Corrigendum: Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study
Authors: Cho Yoonsu , Shin So-Youn , Won Sungho , Relton Caroline L , Smith George Davey , Shin Min-Jeong
Published: May 2016

Scientific Reports 5: Article number: 18422; published online: 21 December 2015; updated: 27 May 2016 This Article contains typographical errors in Table 6. In the column ‘OR (95% CI) by IV estimation’, the Cardiovascular disease OR value “0.949 (0.988,1.004)” should read: “0.949 (0.876, 1.029)”.
A new reassortment of influenza A (H7N9) virus causing human infection in Beijing, 2014
Authors: Bi Yuhai , Liu Jingyuan , Xiong Haofeng , Zhang Yue , Liu Di , Liu Yingxia , Gao George F. , Wang Beibei
Published: May 2016

A 73-year-old man was confirmed to have an influenza A (H7N9) virus infection and the causative agent A/Beijing/02/2014(H7N9) virus was isolated. Genetic and phylogenetic analyses revealed that the virus belonged to a novel genotype, which probably emerged and further reassorted with other H9 or H7 viruses in poultry before transmitting to humans. This virus caused a severe infection with high levels of cytokines and neutralizing antibodies. Eventually, the patient was cured after serially combined treatments. Taken together, our findings indicated that this novel genotype of the human H7N9 virus did not evolve directly from the first Beijing isolate A/Beijing/01/2013(H7N9), suggesting that the H7N9 virus has not obtained the ability for human-to-human transmissibility and the virus only evolves in poultry and then infects human by direct contact. Hence, the major measures to prevent human H7N9 virus infection are still to control and standardize the live poultry trade. Early antiviral treatment with combination therapies, including mechanical ventilation, nutrition support and symptomatic treatment, are effective for H7N9 infection.
Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.
Authors: Tu Huakang , Heymach John V. , Wen Chi-Pang , Ye Yuanqing , Pierzynski Jeanne A. , Roth Jack A. , Wu Xifeng
Published: May 2016

Reducing lung cancer risk by modifying diet is highly desirable. We investigated whether different U.S. dietary patterns were associated with lung cancer risk. Dietary patterns were derived using exploratory factor analysis for 2139 non-small cell lung cancer (NSCLC) cases and 2163 frequency-matched controls. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Highest adherence (highest vs. lowest quintile) to the “Tex-Mex”, “fruits and vegetables” and “American/Western” patterns was associated with a 55% reduced (OR = 0.45; 95% CI = 0.37–0.56; P < 0.001), 32% reduced (OR = 0.68; 95% CI = 0.55–0.85; P = 0.001) and 45% increased (OR = 1.45; 95% CI = 1.18–1.78; P < 0.001) risk of lung cancer, respectively. The effects were stronger for squamous cell carcinoma and ever smokers for the “fruits and vegetables” pattern and stronger for other non-small cell lung cancer and never smokers for the “American/Western” pattern. Among six genome-wide association (GWA) studies-identified lung cancer susceptibility loci assessed, a variant (rs2808630) of the C-reactive protein gene modified the associations for the “fruits and vegetables” (P for interaction = 0.03) and “American/Western” (P for interaction = 0.02) patterns. Our study first showed that the “Tex-Mex” dietary pattern was associated with a reduced lung cancer risk. Also, the “fruits and vegetables” and “American/Western” patterns affected lung cancer risk and the effects were further modified by host genetic background.
Matrix effects in Pb/U measurements during LA-ICP-MS analysis of the mineral apatite
Authors: Thompson Jay , Meffre Sebastien , Maas Roland , Kamenetsky Vadim , Kamenetsky Maya , Goemann Karsten , Ehrig Kathy , Danyushevsky Leonid
Published: May 2016

U–Pb ages of several apatite reference materials, acquired by LA-ICP-MS over a 3.5 year period using the Otter Lake apatite as a primary standard, show systematic offsets (up to 3%) from reference ages obtained by isotope dilution mass spectrometry.
“Outposts of Britain” the General Post Office and the birth of a corporate iconic brand, 1930-1939
Authors: Heller Michael
Published: May 2016

Purpose

This paper aims to examine the development of an iconic corporate brand by the General Post Office (GPO) in Britain in the 1930s by adapting the work of Douglas Holt (2004).

Design/methodology/approach

The paper uses a historical approach by developing a historical case study. It combines this historical approach with Holt’s theory and writing on iconic branding and the current literature on corporate identity, corporate branding and corporate communication.

Findings

The study argues that the GPO was able to construct an iconic brand in the interwar period (1918-1939) by responding to anxieties in British society generated by social tension and fears of decline. This was facilitated by the establishment of a public relations department, which created “myths” of national identity and imperial unity through telecommunications, and national strength through technology. These myths assuaged social anxieties and enabled the GPO to construct an iconic corporate brand.

Originality/value

This paper provides an important insight into iconic branding. It examines corporate rather than product branding, where research has predominantly focused. It also combines cultural branding theory with historical analysis and provides an adapted approach to Holt’s myth market model (1994, p. 58).
Valuing and value in diversity: the policy‐implementation gap in an IT firm
Authors: Kirton Gill , Robertson Maxine , Avdelidou‐Fischer Nicole
Published: May 2016

The focus of UK‐based research on diversity theory and diversity managers has led to a relative dearth of studies focusing on the critical issue of line managers' agency in policy implementation. This article provides a context‐sensitive organisational case study of the policy‐implementation gap in the UK base of one multinational IT company. The article explores male and female managers' perspectives on valuing diversity at a level of general abstraction, and the extent to which they see value in diversity for the effectiveness of their project teams. In the context of a White, male‐dominated industry, the case study shows how the gap is sustained rather than bridged despite the implementation of numerous diversity initiatives.
AKT in cancer: new molecular insights and advances in drug development
Authors: Mundi Prabhjot S. , Sachdev Jasgit , McCourt Carolyn , Kalinsky Kevin
Published: May 2016

The phosphatidylinositol‐3 kinase (PI3K)–AKT pathway is one of the most commonly dysregulated pathways in all of cancer, with somatic mutations, copy number alterations, aberrant epigenetic regulation and increased expression in a number of cancers. The carefully maintained homeostatic balance of cell division and growth on one hand, and programmed cell death on the other, is universally disturbed in tumorigenesis, and downstream effectors of the PI3K–AKT pathway play an important role in this disturbance. With a wide array of downstream effectors involved in cell survival and proliferation, the well‐characterized direct interactions of AKT make it a highly attractive yet elusive target for cancer therapy. Here, we review the salient features of this pathway, evidence of its role in promoting tumorigenesis and recent progress in the development of therapeutic agents that target AKT.