bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationships between Sleep, Athletic and Match Performance, Training Load, and Injuries: A Systematic Review of Soccer Players
Authors: Clemente Filipe Manuel , Afonso José , Costa Júlio , Oliveira Rafael , Pino-Ortega José , Rico-González Markel
Published: June 2021

The purpose of this systematic review was to summarize available evidence regarding the relationships between sleep and (i) athletic and match performance, (ii) training load, and (iii) injuries in soccer players. A systematic review of EBSCOhost (SPORTDiscus), PubMed, Cochrane Library, FECYT (Web of Sciences, CCC, DIIDW, KJD, MEDLINE, RSCI, and SCIELO) databases was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 297 titles were identified, of which 32 met the eligibility criteria. Results revealed that soccer players are no exception for sleep inadequacy. Although there was inconsistency in the findings, some studies suggested that sleep restrictions in soccer negatively affected athletic and match performance while also increasing the number and severity of musculoskeletal injuries. On the other hand, inconsistent results were found between sleep and athletic and match performance, and training load in soccer players. Physiological responses (and their intensity) during drill-based games were not influenced by changes in sleep. The available evidence is inconsistent; however, it appears to suggest that poor sleep affects soccer players’ performance and increases the risk of injury. However, it remains important to study this complex relationship further.
Effects of Semi-Immersive Virtual Reality-Based Cognitive Training Combined with Locomotor Activity on Cognitive Function and Gait Ability in Community-Dwelling Older Adults
Authors: Hwang Na-Kyoung , Choi Jong-Bae , Choi Dae-Kil , Park Jae-Min , Hong Chang-Wan , Park Ji-Su , Yoon Tae-Hyung
Published: June 2021

This study aimed to investigate the effects of semi-immersive virtual reality-based cognitive training (VRCT) combined with locomotor activity on cognitive function, balance, and gait ability in older adults. Eighteen community-dwelling older adults participated in this study. Subjects who met the selection criteria were assigned to an experimental group (n = 9) and a control group (n = 9). The experimental group received VRCT combined with locomotor activity for 30 min a day, three times a week, for 6 weeks. The control group received tabletop activity-based cognitive training for the same amount of time. Before and after the training, the Korean Mini-Mental State Examination (K-MMSE), Trail Making Test (TMT; A and B), and Digit Span Test (DST; forward and backward) were used to evaluate cognitive function; and the Timed Up and Go (TUG) test and 10-m Walking Test (10MWT) were used to evaluate the improvement in the balance and gait ability parameters. After the intervention, the experimental group showed a significantly greater improvement in the TMT-A (p = 0.045) and DST-backward (p = 0.012) scores compared with the control group. Regarding the gait ability variable, the experimental group showed a significant improvement in the 10MWT test (p = 0.001). This study confirmed that semi-immersive VRCT combined with locomotor activity is useful for improving cognitive function and gait ability in older adults. Therefore, VRCT combined with locomotor activity can be used as a simultaneous intervention for cognitive rehabilitation and functional capacity improvement in older adults.
Causes and Severity of Dentophobia in Polish Adults—A Questionnaire Study
Authors: Furgała Dominika , Markowicz Kinga , Koczor-Rozmus Aleksandra , Zawilska Anna
Published: June 2021

Introduction: A phobia is defined as an irrational fear, the intensity of which is inadequate to the circumstances, and it leads to the avoidance of situations that trigger it. A person with dentophobia avoids dental treatment, even when the pain in the teeth or oral cavity exceeds their fear. Fear and anxiety are the most common emotional states experienced by patients in dental offices. The aim of the study was to determine the following: the probable causes of dentophobia, which procedures patients fear the most, and the subjective feeling of fear on a point scale. Materials and Methods: The research was conducted in the form of an anonymous online questionnaire and its printed equivalent. The survey was available from 23 January to 16 March 2020, and it was addressed to adult respondents. In total, 130 respondents and 102 dental students took part in the survey. Results: It is worthwhile emphasizing that the main reason for dentist visits (for almost one-third of men and almost one-fifth of women surveyed) is a toothache. Periodontal problems (2.2%), tooth extractions (1.8%), and prosthetic consultations (0.9%) were relatively rare reasons for the respondents to visit a dentist. The vast majority of respondents see the cause of dentophobia as being related to their previous bad experiences. The second most frequently chosen answer is anxiety, which is caused by the sounds of dental apparatus. Conclusions: Pain is the most common reason given for fear of visiting a dentist, as well as the cause of dentophobia. Pain reduction can positively affect the frequency of visits to a dentist, thus, improving the condition of the oral cavity of patients.
Gene Polymorphism in Five Target Genes of Immunosuppressive Therapy and Risk of Development of Preeclampsia
Authors: Previtera Francesca , Restaino Stefano , Romano Giulio , Vizzielli Giuseppe , Neri Andrea , Scalzotto Elisa , Vetrugno Luigi , Montessoro Beatrice , Mioni Roberto , Driul Lorenza
Published: June 2021

Pregnancy can be considered as an allogeneic transplant and preeclampsia can be seen as a failure of the acceptance mechanisms of this transplant as occurs in acute organ transplant rejection. Some genetic polymorphisms may be involved in its pathogenesis. Since the kidney is one of the organs mainly involved in preeclampsia, our study attempted to determine the frequencies of single nucleotide polymorphisms of DNA (SNP) in 3 genes (adenosine triphosphate-binding cassette sub-family B member 1 (ABCB1)/multi drug reactivity 1 (MDR1) gene, interleukin 10 gene and tumor necrosis factor α gene) which are targets of immunosuppressive therapies and related to acute renal rejection. The study was an observational, monocentric, case-control study. We enrolled 20 women with severe preeclampsia and 10 women age-matched with regular pregnancy. Continuous variables were compared by the Student’s t-test for independent variables or using the Mann-Whitney test depending on their distribution. We used Fisher test to compare categorical variables between cases and controls, while we used logistic regression model to evaluate which risk factor was associated with preeclampsia. Although there was no statistically significant difference between the two groups, we found different percentages of two of the polymorphisms considered (rs1045642 and rs2032582 in the gene ABCB1). Despite these results, our work may be helpful for future research to better understand the pathogenesis of preeclampsia.
Blended Learning on Blood Pressure Measurement: Investigating Two In-Class Strategies in a Flipped Classroom-Like Setting to Teach Pharmacy Students Blood Pressure Measurement Skills
Authors: Farahani Samieh , Farahani Imaneh , Deters Maira Anna , Schwender Holger , Burckhardt Bjoern Bengt , Laeer Stephanie
Published: June 2021

For reliable blood pressure measurement, various potential sources of inaccuracies need to be considered to avoid incorrect decision-making. Pharmacy students should be sensitized and taught the skill accordingly. One strategy to teach students’ blood pressure measurement skills might be through a blended learning approach in a flipped classroom-like setting. With a randomized two-arm study among pharmacy students in their eighth semester, the required extent of in-class session in the scope of a blended learning approach in a flipped classroom-like setting was evaluated. Participants’ self-confidence and self-perceived proficiency were evaluated through a survey, and participants’ blood pressure measurement performance was assessed by objective structured clinical examination (OSCE). Participants’ satisfaction with, and perception of, the flipped classroom were also surveyed. The extended in-class activities did not result in a significantly higher increase of participants’ OSCE score and self-assessment score when compared to the brief in-class session. Both in-class sessions yielded a significant increase in the OSCE scores as well as in the self-assessment scores. Moreover, the teaching approaches were predominantly well-received by the students. The use of both flipped classroom-like approaches improved pharmacy students’ blood pressure measurement performance, though the brief in-class session was sufficient. Students’ self-confidence/self-perceived proficiency in blood pressure measurement skills increased similarly in both settings.
Accessibility of Geoheritage Sites—A Methodological Proposal
Authors: Mikhailenko Anna V. , Ruban Dmitry A. , Ermolaev Vladimir A.
Published: June 2021

Accessibility is an important property of geoheritage sites (geosites), which is commonly considered in their assessment. A new method, which refers partly to previous developments, is proposed to assess this property semiquantitatively. Inner (on-site) and outer accessibility are distinguished, and each is measured depending on the opportunities to reach unique geological features. Distant visibility and entrance fees/required permissions are also taken into account. On the basis of the scores, three grades of geosite accessibility (excellent, moderate, and low) are delineated. The proposed method is applied to 15 geosites of Mountainous Adygeya (southwestern Russia), and the outcomes prove its efficacy. This application also helps to establish within-site and territorial spatial heterogeneity of geosite accessibility and to propose some managerial implications.
First Steps toward a Test Procedure to Identify Peat Substitutes for Growing Media by Means of Chemical, Physical, and Biological Material Characteristics
Authors: Leiber-Sauheitl Katharina , Bohne Heike , Böttcher Jürgen
Published: June 2021

Due to the major environmental impact of peat-based growing media production and the need of lowering greenhouse gas emissions in all sectors, a wider application of peat substitutes in growing media is requested. All peat substitutes under use have constraints associated with their properties. Therefore, a preliminary test procedure for identifying new raw materials as peat substitutes in growing media was developed and validated. By applying the preliminary test procedure, the potential limitations of cultivation of potential peat substitutes are indicated, and measures for cultivation regulation are recommended. For the development of the new preliminary test procedure, four raw materials were investigated: composted heather, alder, cattail, and reed. The preliminary test procedure comprises several material and technological criteria as well as aspects of plant cultivation, enabling the evaluation of the raw materials and the processed components for growing media. Results derived from the preliminary test procedure were checked and confirmed by experiments with horticultural crops in different sections of commercial horticulture. Within two years, the identification of new peat substitutes was possible by the application of the preliminary test procedure and its test criteria, which provide a structure for the systematic investigation of potential new peat substitutes starting with the raw material.
Seed Set Patterns in East African Highland Cooking Bananas Are Dependent on Weather before, during and after Pollination
Authors: Waniale Allan , Swennen Rony , Mukasa Settumba B. , Tugume Arthur K. , Kubiriba Jerome , Tushemereirwe Wilberforce K. , Batte Michael , Brown Allan , Tumuhimbise Robooni
Published: June 2021

Seed set in banana is influenced by weather, yet the key weather attributes and the critical period of influence are unknown. We therefore investigated the influence of weather during floral development for a better perspective of seed set increase. Three East African highland cooking bananas (EAHBs) were pollinated with pollen fertile wild banana ‘Calcutta 4′. At full maturity, bunches were harvested, ripened, and seeds extracted from fruit pulp. Pearson’s correlation analysis was then conducted between seed set per 100 fruits per bunch and weather attributes at 15-day intervals from 105 days before pollination (DBP) to 120 days after pollination (DAP). Seed set was positively correlated with average temperature (P < 0.05–P < 0.001, r = 0.196–0.487) and negatively correlated with relative humidity (RH) (P < 0.05–P < 0.001, r = −0.158–−0.438) between 75 DBP and the time of pollination. After pollination, average temperature was negatively correlated with seed set in ‘Mshale’ and ‘Nshonowa’ from 45 to 120 DAP (P < 0.05–P < 0.001, r = −0.213–−0.340). Correlation coefficients were highest at 15 DBP for ‘Mshale’ and ‘Nshonowa’, whereas for ‘Enzirabahima’, the highest were at the time of pollination. Maximum temperature as revealed by principal component analysis at the time of pollination should be the main focus for seed set increase.
Improving Fusarium Basal Rot Resistance of Onion Cultivars through Artificial Inoculation and Selection of Mature Bulbs
Authors: Mandal Subhankar , Cramer Christopher S.
Published: June 2021

Fusarium basal rot (FBR) of onion, caused by the soil-borne fungus Fusarium oxysporum f.sp. cepae (FOC), results in a substantial storage loss of marketable bulbs. Seedling and field screening methods, which were used to generate FBR resistant long-day and intermediate-day onion cultivars, were found to be ineffective at increasing FBR resistance in short-day onion cultivars. This study attempted to improve the FBR resistance of seven commercial short-day onion cultivars and two check cultivars when evaluated at their mature bulb stage. Mature bulbs were artificially inoculated with 1 cm diameter potato dextrose agar plugs containing conidia of a virulent FOC isolate, CSC-515, at a concentration of 3 × 104 spore mL−1, after transversely cutting the basal plate tissue. Incubated bulbs, which had few or no FBR symptoms, were selected after 20 d using visual scoring, from 1 (no disease) to 9 (>70% basal plate is infected), and combined in seed production cages to produce the selected generation of a cultivar. Multiple cycles of phenotypic recurrent selection were conducted, and the resultant populations were compared with their respective original populations for FBR severity and incidence, from 2016 to 2019, using the same conidial inoculation method. A variable amount of progress was achieved in reducing FBR severity and incidence in the seven cultivars, with maximum improvement in the most advanced selected populations. FBR development in the advanced selected populations differed between mature bulbs of each entry and was influenced by yearly environmental variation. The progress of FOC infections was slower in resistant bulbs when compared to susceptible bulbs. These results indicated a partial or quantitative resistance against FBR. The partial FBR resistant cultivar populations could be used to develop synthetic short-day FBR resistant cultivars after multi-locational and multi-seasonal field trials. These populations could also be used to study the mechanism(s) of FBR resistance in onion, which has yet to be determined.
Use of the Bacterial Lysate OM-85 in the Paediatric Population in Italy: A Retrospective Cohort Study
Authors: Cantarutti Anna , Barbieri Elisa , Scamarcia Antonio , Cantarutti Luigi , Canova Cristina , Giaquinto Carlo
Published: June 2021

Background: In Italy, the bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®) is registered for the prophylaxis of recurrent respiratory tract infections (RTIs) in adults and children above one year of age, but there are limited data on its use in the paediatric population. We aim to estimate the impact of OM-85 treatment on RTIs and antibiotic prescriptions in children. Methods: This study included children aged 1 to 14 years enrolled in Pedianet, a paediatric general practice research database, from January 2007 to June 2017, having at least one prescription of OM-85. Children with less than 12 months of follow-up before (PRE period) and after (POST period) the OM-85 prescription were excluded. The frequency of antibiotic prescriptions and the frequency of RTI episodes in the PRE and POST periods were compared through the post-hoc test. Subgroup analysis was performed in children with recurrent RTIs. Results: 1091 children received 1382 OM-85 prescriptions for a total follow-up of 619,525.5 person-years. Overall, antibiotic prescriptions decreased from a mean of 2.8 (SD (standard deviation) 2.7) prescriptions in the PRE period to a mean of 2.2 (SD 2.6) prescriptions in the POST period (p < 0.0001). RTIs decreased from a mean of 3.4 (SD 2.9) episodes in the PRE period to a mean of 2.5 (SD 2.6) episodes in the POST period (p < 0.0001). No change in antibiotic class was noted, and co-amoxiclav remained the preferred therapy in 28% of cases, followed by amoxicillin. These results were confirmed among children with recurrent RTIs. Conclusions: OM-85 is effective in preventing both antibiotic prescriptions and RTIs in children.
The Health Status Transition and Medical Expenditure Evaluation of Elderly Population in China
Authors: Wang Lianjie , Tang Yao , Roshanmehr Farnaz , Bai Xiao , Taghizadeh-Hesary Farzad , Taghizadeh-Hesary Farhad
Published: June 2021

(1) Background: Because of the rapid expansion of the aging population in China, their health status transition and future medical expenditure have received increasing attention. This paper analyzes the health transition of the elderly and how their health transition impacts medical expenditures. At the same time, feasible policy suggestions are provided to respond to the rising medical expenditure and the demand for social care. (2) Methods: The data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015 and analyzed using the Markov model and the Two-Part model (TPM) to forecast the size of the elderly population and their medical expenditures for the period 2020–2060. (3) Results: The study indicates that: (1) for the elderly with a mild disability, the probability of their health improvement is high; in contrast, for the elderly with a moderate or severe disability, their health deterioration is almost certain; (2) the frequency of the diagnosis and treatments of the elderly is closely related to their health status and medical expenditure; alternatively, as the health status deteriorates, the intensity of the elderly individuals’ acceptance of their diagnosis and treatment increases, and so does the medical expense; (3) the population of the elderly with mild and moderate disability demonstrates an inverted “U”-shape, which reaches a peak around 2048, whereas the elderly with severe disability show linear growth, being the target group for health care; (4) with the population increase of the elderly who have severe disability, the medical expenditure increases significantly and poses a huge threat to medical service supply. Conclusions: It is necessary to provide classified and targeted health care according to the health status of the elderly. In addition, improving the level of medical insurance, establishing a mechanism for sharing medical expenditure, and adjusting the basic demographic structure are all important policy choices.
Roles of Hostility and Depression in the Association between the MAOA Gene Polymorphism and Internet Gaming Disorder
Authors: Yen Ju-Yu , Chou Wei-Po , Lin Huang-Chi , Wu Hung-Chi , Tsai Wen-Xiang , Ko Chih-Hung
Published: June 2021

The metabolism of bioamine in the central nervous system contributes to the development of addiction. We examined the roles of hostility and depression in the association between internet gaming disorder (IGD) and monoamine oxidase-A (MAOA) EcoRV polymorphism (rs1137070). A total of 69 adults with IGD and 138 without IGD were recruited through diagnostic interviewing. We evaluated participants for rs1137070, depression, and hostility. The participants with the TT genotype of rs1137070 had a higher odds ratio of 2.52 (1.37–4.64) for IGD compared with the C carriers. Expressive hostility behavior and hostility cognition mediated the association between rs1137070 and IGD. Indicating lower MAOA activity, the TT genotype predicted IGD and higher expressive hostility behavior and hostility cognition. Expressive hostility behavior and hostility cognition may underline the association between rs1137070 and IGD. Assessment of and intervention for hostility behavior and cognition should be provided to attenuate the risk of IGD, particularly in those with the TT genotype. Further brain imaging or neurobiological studies are required to elucidate the possible mechanism underlying the association between MAOA activity and IGD.
Emotional Intelligence and Social Support: Two Key Factors in Preventing Occupational Stress during COVID-19
Authors: Valenti Giusy Danila , Faraci Palmira , Magnano Paola
Published: June 2021

Emotional intelligence (EI) and social support are among the most investigated hypothesized variables that affect stress at work. The current study aims to evaluate the direct association between EI and occupational stress and its indirect relationship mediated by three sources of social support during the spread of the COVID-19. The total sample was composed of 367 individuals (53.7% males), aged from 20 to 68 (M = 37.84, SD = 10.39), who filled out an online questionnaire. A mediation analysis was performed to test the hypothesized relationships. Our findings showed that EI has a direct effect on psychological effects and an indirect effect on almost all the facets of occupational stress. The significant mediators were social support from both family and friends. Theoretical and practical implications are discussed and directions for future studies are suggested.
A Latent Class Analysis of Health Lifestyles in Relation to Suicidality among Adolescents in Mauritius
Authors: Hoogstoel Fanny , Samadoulougou Sékou , Lorant Vincent , Kirakoya-Samadoulougou Fati
Published: June 2021

Suicidality, which includes suicidal thoughts, planning, and suicide attempts, results mainly from a combination of psychological, sociological, and environmental factors. Despite a high prevalence of suicidality among adolescents in Africa, only a few studies have considered these factors simultaneously. The objective of the study was to identify the prevalence of suicidality, to draw up profiles of concomitant risks, and to examine the associations between these profiles and suicidality in Mauritius. This study used data from the 2017 Mauritian Global School-based Student Health Survey including 3012 adolescents with a mean age of 14.9 ± 1.4 years. Factors related to lifestyle such as consumptions of alcohol and tobacco, physical activity, violence, parental support, anxiety, and loneliness were considered. A latent class analysis was performed to identify the profiles. Finally, a modified Poisson regression analysis with generalized estimating equations, adjusted with sociodemographic characteristics, was used to assess the association between these profiles and suicidality. Overall, more than one in ten adolescents had at least one of the suicidality behaviors. Three profiles were identified: 1 = “low risk group” (63.9%); 2 = “problems with violence” (15.2%); 3 = “problems with violence, alcohol, tobacco and psychological distress” (20.9%). Profiles 2 and 3 were mainly made up of males. Adolescents under 15 represented the majority of individuals in profile 2. Finally, the risk of suicidality was higher in adolescents belonging to profiles 2 and 3 compared to profile 1 for the three suicidality behaviors (profile 3: Prevalence ratio (PR) for suicidal thoughts = 1.26, 95% CI = 1.19–1.34; PR for planning = 1.23, 95% CI = 1.17–1.30; PR for attempt = 1.23, 95% CI = 1.17–1.29). This study highlights the high prevalence of suicidality and a list of concomitant risks, emphasizing this suicidality in Mauritian adolescents. Therefore, these results recommend focusing preventive efforts toward a simultaneous consideration of these factors.
High Levels of Fine Particulate Matter (PM2.5) Concentrations from Burning Solid Fuels in Rural Households of Butajira, Ethiopia
Authors: Tamire Mulugeta , Kumie Abera , Addissie Adamu , Ayalew Mulugeta , Boman Johan , Skovbjerg Susann , Andersson Rune , Lärstad Mona
Published: June 2021

The use of solid fuel, known to emit pollutants which cause damage to human health, is the primary energy option in Ethiopia. Thus, the aim of this study was to measure the level of household air pollution by using the 24-h mean concentration of fine particulate matter (PM2.5) in 150 randomly recruited households in rural Butajira, Ethiopia. Data relating to household and cooking practices were obtained by conducting face-to-face interviews with the mothers. The 24-h mean (standard deviation) and median PM2.5 concentrations were 410 (220) and 340 µg/m3, respectively. Households using only traditional stoves and those who did not open the door or a window during cooking had a significantly higher mean concentration compared with their counterparts. There is a statistically significant correlation between the mean concentration of PM2.5 and the self-reported cooking duration. The pollution level was up to 16 times higher than the WHO 24-h guideline limit of 25 μg/m3, thus leaving the mothers and children who spend the most time at the domestic hearth at risk of the adverse health effects from solid fuel use in Ethiopia. Thus, effective short- and long-term interventions are urgently needed.
The Impact of Internet Addiction and Job Satisfaction on Mental Health Symptoms among a Sample of Portuguese Workers
Authors: Pereira Henrique , Fehér Gergely , Tibold Antal , Esgalhado Graça , Costa Vítor , Monteiro Samuel
Published: June 2021

Not many studies assessing the impact of internet addiction (IA) and job satisfaction (JS) on mental health symptoms (MHS) among active workers exist. Therefore, the purpose of this study was as follows: (a) to assess the presence of criteria for IA among a sample of active workers; (b) to analyze differences in IA, JS and MHS, by gender; (c) to analyze association levels among IA, JS, and MHS; and (d) to determine the predictive effect of IA and JS on MHS. In total, 1064 participants (Mage = 40.66; SD = 12.02) completed a survey containing four categories of measures: demographic information, internet addiction, job satisfaction, and mental health symptoms (anxiety and depression). Results showed a presence of 13.3% for IA among the sample. Male participants showed higher scores of IA and JS but lower scores of overall MSH than female participants did. Significant positive correlations were found between overall IA and MHS, and significant negative correlations were found between IA and JS, and MHS and JS. Hierarchical linear regression analysis showed that strong predictors of MHS were age (being older), gender (being female), not having enough economic funds, being unsatisfied with the leadership in the job, being unsatisfied with the nature of the job, and having higher scores in salience and excessive use regarding IA. In conclusion, addiction to internet technology is a risk factor with implications for occupational satisfaction and mental health.
Using the Food Stress Index for Emergency Food Assistance: An Australian Case Series Analysis during the COVID-19 Pandemic and Natural Disasters
Authors: Pollard Christina Mary , Landrigan Timothy John , Gray Jennie Margaret , McDonald Lockie , Creed Helen , Booth Sue
Published: June 2021

Food insecurity increases with human and natural disasters. Two tools were developed to assist effective food relief in Western Australia: the Food Stress Index (similar to rental stress, predicts the likelihood of household food insecurity by geographic location) and a basic and nutritious Food Basket Recommendation (that quantifies the types and amounts of food to meet dietary recommendations for different family types). This study aims to understand and compare the processes and impact of using these tools for organisations and their clients involved in emergency food assistance and/or disaster preparedness. A multiple case-study design analysed organisation’s use of the tools to assist the response to COVID-19 pandemic restrictions and the catastrophic bushfires in Australia. Qualitative interviews were conducted by telephone and Zoom (a cloud-based video conferencing service) in July–August 2020. A purposeful sample of eight interviewees representing seven cases (government, food relief and community organisations involved in emergency food assistance and/or disaster preparedness). Three themes emerged from the analysis, (1) organisations are confident users of the tools; (2) Collaborations were “Ready to Go” and (3) Food Stress Index is a “game changer”. Findings demonstrate the intrinsic value of the tools in the provision of emergency food relief under both normal circumstances and in times of increased need, i.e., COVID-19 pandemic. The study highlights the value and importance of ongoing intersectoral collaborations for food relief and food security (e.g., the Western Australian Food Relief Framework) and suggests that upscaling of the Food Stress Index and food baskets will increase the effectiveness of measures to address food insecurity in Australia.
Disability among Older People: Analysis of Data from Disability Surveys in Six Low- and Middle-Income Countries
Authors: Prynn Josephine E. , Polack Sarah , Mactaggart Islay , Banks Lena Morgon , Hameed Shaffa , Dionicio Carlos , Neupane Shailes , Murthy GVS , Oye Joseph , Naber Jonathan , Kuper Hannah
Published: June 2021

This analysis of surveys from six low- and middle-income countries (LMICs) aimed to (i) estimate the prevalence of disability among older adults and (ii) compare experiences and participation in key life areas among older people with and without disabilities which may show vulnerability during the COVID-19 pandemic. Data were analysed from district-level or national surveys in Cameroon, Guatemala, Haiti, India, Nepal and the Maldives, which across the six databases totalled 3499 participants aged 60 years and above including 691 people with disabilities. Disability was common among adults 60+, ranging from 9.7% (8.0–11.8) in Nepal to 39.2% in India (95% CI 34.1–44.5%). Mobility was the most commonly reported functional difficulty. In each setting, older people with disabilities were significantly less likely to be working and reported greater participation restrictions and environmental barriers in key life areas compared to people in the same age categories without disabilities (p < 0.05). Disability is common in this population, and older people with disabilities may have greater difficulties participating in COVID-19 responses and have high economic vulnerabilities. It is imperative to prioritise the needs of older people with disabilities in the COVID-19 pandemic, including ensuring accessibility of both health services and the community in general.
“Does a Good Company Reduce the Unhealthy Behavior of Its Members?”: The Mediating Effect of Organizational Identification and the Moderating Effect of Moral Identity
Authors: Kim Byung-Jik , Choi Se-Yeon
Published: June 2021

In the contemporary business environment where business ethics is critical for organizational performance, the importance of corporate social responsibility (CSR) is increasing. By investigating the mechanism of the effects of CSR on counterproductive work behavior (CWB), the present study suggests that CSR decreases negative employee behavior. Based on social identity theory and context-attitude-behavior framework, this research examines the underlying process and its contingent factor of the association between CSR and CWB. Specifically, this study hypothesizes that CSR decreases CWB by enhancing employees’ organizational identification and that moral identity positively moderates the relationship between CSR and organizational identification. Using three-wave online survey data from 368 employees in Korean firms, this paper tested our hypotheses by conducting moderated mediation analysis with structural equation modeling. The results showed that CSR is negatively related to CWB through organizational identification and that moral identity positively moderates the relationship between CSR and organizational identification. The current study’s findings have crucial theoretical and practical implications in CSR literature.
The Mediating Role of Psychological Distress in Excessive Gambling among Young People: A Four-Country Study
Authors: Vuorinen Ilkka , Oksanen Atte , Savolainen Iina , Sirola Anu , Kaakinen Markus , Paek Hye-Jin , Zych Izabela
Published: June 2021

Background and aims: Loneliness and a low sense of mastery are associated with excessive gambling, but the underlying processes of these relationships remain unstudied. Because psychological distress can increase vulnerability to excessive gambling, we investigated its mediating role in these relationships among young people. To meet the need for cross-country research, we also observed how these relationships occur in four countries with different cultures. Design, setting, and participants: Demographically balanced cross-sectional survey data were collected from 15–25-year-olds in Finland (n = 1200; 50% male), the United States (n = 1212; 49.8% male), South Korea (n = 1192; 49.6% male), and Spain (n = 1212; 51.2% male). Measurements: Excessive gambling was measured with the South Oaks Gambling Screen, psychological distress was assessed with the 12-item General Health Questionnaire, loneliness was measured with the three-item Loneliness Scale, and low sense of mastery was assessed with the Pearlin Mastery Scale. Associations were examined first using zero-inflated negative binomial regression analyses with excessive gambling as the outcome. In addition, path analyses were performed to study how loneliness and low sense of mastery relate to excessive gambling, with psychological distress as the mediating variable. Findings: Loneliness and low sense of mastery were associated indirectly with excessive gambling via psychological distress in all country samples. Low sense of mastery was also directly associated with excessive gambling. There was a direct association between loneliness and excessive gambling only in samples from South Korea and Spain. Conclusions: Psychological distress is an important factor in understanding how loneliness and sense of mastery relate to gambling.
Associations between Food Pantry Size and Distribution Method and Healthfulness of Foods Received by Clients in Baltimore City Food Pantries
Authors: Gu Yuxuan , Ali Shahmir H. , Yan Sally , Gunen Bengucan , Park Reuben , Poirier Lisa , Craig Hope C. , Dong Hengjin , Gittelsohn Joel
Published: June 2021

This study aimed to evaluate the association of the overall nutritional quality and the weight share of specific types of foods received by food pantry clients with food pantry size and distribution method. Data on healthy food weights using the gross weight share (GWS) of select foods and the validated Food Assortment Score Tool (FAST) were collected from 75 food pantry clients in Baltimore, Maryland. The average FAST score across the study population was 63.0 (SD: 10.4). Overall, no statistically significant differences in average FAST scores by pantry size and distribution method were found. However, among client-choice pantries, clients of small pantries had higher scores (p < 0.05) while among medium pantries, clients of traditional pantries had higher scores (p < 0.01). Subgroup analysis of GWS was stratified by pantry size and distribution methods. Findings suggested multi-level, multi-component interventions combining environmental strategies are needed to enhance the healthfulness of foods received by clients. Our analysis provided data to consider further refinements of pantry interventions and planning of more rigorous research on factors influencing the effectiveness of pantry interventions.
The Association between Decreased Kidney Function and FIB-4 Index Value, as Indirect Liver Fibrosis Indicator, in Middle-Aged and Older Subjects
Authors: Kotoku Kazuko , Michishita Ryoma , Matsuda Takuro , Kawakami Shotaro , Morito Natsumi , Uehara Yoshinari , Higaki Yasuki
Published: June 2021

Liver fibrosis might be linked to the prevalence of chronic kidney disease (CKD). However, there is little information about the association between liver fibrosis and decreased kidney function in middle-aged and older subjects. We aimed to evaluate the influence of liver fibrosis on the incidence or prevalence of CKD stage 3–5 in a retrospective cross-sectional study (Study 1, n = 806) and a 6-year longitudinal study (Study 2, n = 380) of middle-aged and older subjects. We evaluated liver fibrosis using the Fibrosis-4 (FIB-4) index and kidney function using the estimated glomerular filtration rate (eGFR) of all subjects. All subjects were divided into four groups on the basis of their FIB-4 score quartiles (low to high). In the Jonckheere–Terpstra trend test of Study 1, the eGFR decreased significantly from the lowest group to the highest group (p < 0.001). The Kaplan–Meier survival curve in Study 2 showed that the cumulative prevalence of CKD stage 3–5 was higher in the third quartile than the other quartiles. Our results suggest that liver fibrosis could be a useful indicator for the prevalence of CKD, even within a relatively healthy population, although liver fibrosis was not an independent risk factor.
Detecting Emotional Evolution on Twitter during the COVID-19 Pandemic Using Text Analysis
Authors: Cabezas Javier , Moctezuma Daniela , Fernández-Isabel Alberto , Martín de Diego Isaac
Published: June 2021

Early in 2020, an unexpected and hazardous situation occurred threatening and challenging all of humankind. A new coronavirus called SARS-CoV-2 was first identified in Wuhan, China, and its related disease, called COVID-19, has induced one of the most dangerous crises at a global level since World War II. The ultra-fast transmission rate of the virus and the high mortality rate led the World Health Organization (WHO) to officially declare the situation a pandemic. Governments, for their part, were forced to implement unprecedented mobility restrictions and cease a large part of their economic activities. These facts triggered multiple reactions from people who expressed their feelings mainly through social networks (like Twitter), using them as vectors of information and opinion. In this paper, a study carried out in different Spanish speaking countries (Chile, Mexico, Peru, and Spain) is presented, which addresses the manner in which the evolution of the pandemic outbreak has affected the emotions expressed by individuals on Twitter over the last 13 months (from March 2020 to March 2021). We used a total of 3 million tweets to achieve this task. We made use of a well-known framework called EmoWeb to capture the dynamic variation in the sentimental value of pandemic-related words. The results reflect to what degree the pandemic and its derived problems have influenced and affected the population of the selected countries in different ways. The outcomes also illustrate the evolution over time of opinions published on Twitter regarding several topics related to COVID-19.
Facial Self-Touching and the Propagation of COVID-19: The Role of Gloves in the Dental Practice
Authors: Carrillo-Díaz María , Lacomba-Trejo Laura , Romero-Maroto Martín , González-Olmo María José
Published: June 2021

Background: Despite facial self–touching being a possible source of transmission of SARS–Co–V–2 its role in dental practice has not been studied. Factors such as anxiety symptoms or threat perception of COVID-19 may increase the possibility of contagion. The objective was to compare the impact of control measures, such as gloves or signs in the reduction in facial self–touching. Methods: An intra–subject design was undertaken with 150 adults. The patients’ movements in the waiting room were monitored with Microsoft Kinect software on three occasions: without any control measures, using plastic gloves or using advisory signs against self–touching. Additionally, the participants completed the sub–scale of STAI (State–Anxiety) and the BIP–Q5 (Brief Illness Perception Questionnaire); their blood pressure and heart rate were recorded. Results: The lowest incidence of facial self–touching occurred in the experimental situation in which gloves were introduced. The subjects with elevated anxiety symptoms realized more facial self–touching regardless of the control measures. However, the threat perception of COVID-19 is associated negatively with facial self–touching. Conclusions: The use of gloves is a useful control measure in the reduction in facial touching. However, people with anxiety symptoms regardless of whether they have greater threat perception for COVID-19 exhibit more facial touching.
Crosstalk of Diabetic Conditions with Static Versus Dynamic Flow Environment—Impact on Aortic Valve Remodeling
Authors: Selig Jessica I. , Boulgaropoulos Joana , Niazy Naima , Ouwens D. Margriet , Preuß Karlheinz , Horn Patrick , Westenfeld Ralf , Lichtenberg Artur , Akhyari Payam , Barth Mareike
Published: June 2021

Type 2 diabetes mellitus (T2D) is one of the prominent risk factors for the development and progression of calcific aortic valve disease. Nevertheless, little is known about molecular mechanisms of how T2D affects aortic valve (AV) remodeling. In this study, the influence of hyperinsulinemia and hyperglycemia on degenerative processes in valvular tissue is analyzed in intact AV exposed to an either static or dynamic 3D environment, respectively. The complex native dynamic environment of AV is simulated using a software-governed bioreactor system with controlled pulsatile flow. Dynamic cultivation resulted in significantly stronger fibrosis in AV tissue compared to static cultivation, while hyperinsulinemia and hyperglycemia had no impact on fibrosis. The expression of key differentiation markers and proteoglycans were altered by diabetic conditions in an environment-dependent manner. Furthermore, hyperinsulinemia and hyperglycemia affect insulin-signaling pathways. Western blot analysis showed increased phosphorylation level of protein kinase B (AKT) after acute insulin stimulation, which was lost in AV under hyperinsulinemia, indicating acquired insulin resistance of the AV tissue in response to elevated insulin levels. These data underline a complex interplay of diabetic conditions on one hand and biomechanical 3D environment on the other hand that possesses an impact on AV tissue remodeling.
Neuroinflammation: A Signature or a Cause of Epilepsy?
Authors: Pracucci Enrico , Pillai Vinoshene , Lamers Didi , Parra Riccardo , Landi Silvia
Published: June 2021

Epilepsy can be both a primary pathology and a secondary effect of many neurological conditions. Many papers show that neuroinflammation is a product of epilepsy, and that in pathological conditions characterized by neuroinflammation, there is a higher probability to develop epilepsy. However, the bidirectional mechanism of the reciprocal interaction between epilepsy and neuroinflammation remains to be fully understood. Here, we attempt to explore and discuss the relationship between epilepsy and inflammation in some paradigmatic neurological and systemic disorders associated with epilepsy. In particular, we have chosen one representative form of epilepsy for each one of its actual known etiologies. A better understanding of the mechanistic link between neuroinflammation and epilepsy would be important to improve subject-based therapies, both for prophylaxis and for the treatment of epilepsy.
Aquatic Training after Joint Immobilization in Rats Promotes Adaptations in Myotendinous Junctions
Authors: Rocha Lara Caetano , Barbosa Gabriela Klein , Pimentel Neto Jurandyr , Jacob Carolina dos Santos , Knudsen Andreas B. , Watanabe Ii-Sei , Ciena Adriano Polican
Published: June 2021

The myotendinous junction (MTJ) is the muscle-tendon interface and constitutes an integrated mechanical unit to force transmission. Joint immobilization promotes muscle atrophy via disuse, while physical exercise can be used as an adaptative stimulus. In this study, we aimed to investigate the components of the MTJ and their adaptations and the associated elements triggered with aquatic training after joint immobilization. Forty-four male Wistar rats were divided into sedentary (SD), aquatic training (AT), immobilization (IM), and immobilization/aquatic training (IMAT) groups. The samples were processed to measure fiber area, nuclear fractal dimension, MTJ nuclear density, identification of telocytes, sarcomeres, and MTJ perimeter length. In the AT group, the maintenance of ultrastructure and elements in the MTJ region were observed; the IM group presented muscle atrophy effects with reduced MTJ perimeter; the IMAT group demonstrated that aquatic training after joint immobilization promotes benefits in the muscle fiber area and fractal dimension, in the MTJ region shows longer sarcomeres and MTJ perimeter. We identified the presence of telocytes in the MTJ region in all experimental groups. We concluded that aquatic training is an effective rehabilitation method after joint immobilization due to reduced muscle atrophy and regeneration effects on MTJ in rats.
Transcriptional Profiling of Cardiac Cells Links Age-Dependent Changes in Acetyl-CoA Signaling to Chromatin Modifications
Authors: Kurian Justin , Bohl Veronica , Behanan Michael , Mohsin Sadia , Khan Mohsin
Published: June 2021

Metabolism has emerged as a regulator of core stem cell properties such as proliferation, survival, self-renewal, and multilineage potential. Metabolites serve as secondary messengers, fine-tuning signaling pathways in response to microenvironment alterations. Studies show a role for central metabolite acetyl-CoA in the regulation of chromatin state through changes in histone acetylation. Nevertheless, metabolic regulators of chromatin remodeling in cardiac cells in response to increasing biological age remains unknown. Previously, we identified novel cardiac-derived stem-like cells (CTSCs) that exhibit increased functional properties in the neonatal heart (nCTSC). These cells are linked to a unique metabolism which is altered with CTSC aging (aCTSC). Here, we present an in-depth, RNA-sequencing-based (RNA-Seq) bioinformatic with cluster analysis that details a distinct epigenome present in nCTSCs but not in aCTSCs. Gene Ontology (GO) and pathway enrichment reveal biological processes, including metabolism, gene regulation enriched in nCTSCs, and STRING analysis that identifies a network of genes related to acetyl-CoA that can potentially influence chromatin remodeling. Additional validation by Western blot and qRT-PCR shows increased acetyl-CoA signaling and histone acetylation in nCTSCs compared to aCTSCs. In conclusion, our data reveal that the link between metabolism and histone acetylation in cardiac cells is altered with the aging of the cardiac tissue.