bluuebunny/crossref_metadata_2025 huggingface dataset:
PLASMA CELL GRANULOMA IN BUCCAL MUCOSA: A CASE REPORT AND REVIEW OF DIFFERENT CASE REPORTS ON PLASMA CELL GRANULOMA IN ORAL CAVITY
Authors: Bhandari Pranay , pawar Pratiksha , Bihani Ameya , Rathi Roopal
Published: May 2021

Introduction: 3 Plasma cell granuloma mainly occurs in lungs but can occur in any other organ or soft tissue . It occurs very rarely in oral cavity. We have also reviewed different articles describing plasma cell granuloma in oral cavity. We search the articles in google scholar and pubmed with keywords plasma cell granuloma in oral cavity, buccal mucosa, gingiva, tongue. A Case report: 39 year old male came with a chief complaint of growth on left buccal mucosa. HPE discovered parakeratinized stratied squamous epithelium, showing focal ulceration and underlying dense connective tissue stroma. On the basis of clinicopathological ndings the diagnosis of plasma cell granuloma was made. Discussion: Plasma cell granuloma is a benign lesion but its exact aetiology, behaviour and prognosis is not completely known. We can give emphasis on frozen histopathology intraoperatively to avoid unnecessarily extensive and potentially destructive surgery as the treatment plan.
Pregestational diabetes: pregnancy planning. Which strategies
Authors: Manicardi, E.
Published: May 2021

In the last years the number of pregestational pregnancies (especially type 2) has been increasing. Several studies have demonstrated that pregestational pregnancies are associated with an increased incidence of adverse maternal outcomes, an increased risk of neonatal mortality and congenital malformations; these risks are related to the glycemic control and to the therapies at the time of conception and during embryogenesis. These pregnancies, therefore, should never be random, as it often happens in our clinics, but they must be planned with pre-conceptional counselling paths dedicated to childbearing women, from puberty, continuing into adolescence and reaching adulthood. When the pregnancy desire becomes concrete, the woman with diabetes must be included in a multidisciplinary and structured program. The pregestational counselling must bring the woman, before conception, to the stabilization of complications, to the therapy improvement, to the achievement of the skills for the management of therapy and to the glycemic control. To reach these results it is necessary that the Diabetologic team works taking into account all the clinical and psycho-social aspects of childbearing women. KEY WORDS pregestational diabetes; pregnancy; preconceptional counselling; maternal and fetal outcomes.
How to overcome sugar addiction?
Authors: Barada, S.
Published: May 2021

Sugar consumption activates the mesocorticolimbic system in a very similar way to substance abuse. But if all addictions initially start with a feeling of pleasure, as in the case of highly palatable foods and sugar rich diets, then why should I abandon something that makes me feel good? And then why does one continue to abuse food despite the negative consequences. There are various ways to deal with the different addictions. However, the problem with sugar addiction, or even more generally with food addiction, is that there is no awareness that the relationship with food can represent an addiction in some cases, and the tools are lacking to identify the most suitable professional figures to help manage the situation when needed. Therefore, the approach to the problem must be multidisciplinary. A methodology based on three fundamental elements is proposed: 1. Training the patient with regard to her/his addiction, providing objective and scientific information, 2. Providing the patient with the right tools, i.e. ‘know-how’, 3. Preventing relapses. Our patients’ stories report how they have learned to manage their emotional needs without escaping, to observe their thoughts by recognising their distortions, to identify what triggers their spasmodic desire for food and understand their behaviour in depth, and to connect better with themselves and others, also sharing the painful emotions along the way! KEY WORDS sugar addiction; food addiction; awareness; addiction treatment; multidisciplinary team.
Sugar. Is it se¬riously harmful to health?
Authors: Comoglio, M.
Published: May 2021

Sugars are essential for life because they represent the main source of energy for living beings. From the second post-war period their consumption has had a continuous and progressive increase for many reasons. This trend especially with regard to the increasingly significant use of “free” sugars in beverages can pose a serious health risk, in particular for the development of cardiovascular disease, obesity, liver cirrhosis, dementia and diabetes mellitus both of type 1 and 2. The WHO strongly recommends reducing the intake of free sugars, hoping for a reduction to <5% of daily calorie intake, and health policy interventions can help to achieve this goal by changing its free and uncontrolled use. KEY WORDS sugar; health; diabetes; sugar sweetened beverages; cardiovascular risk.
The evolution of telemedicine during COVID-19. From theory to practice?
Authors: Vespasiani, G.
Published: May 2021

It must be recognized that, in the lockdown period, in addition to the shortcomings of the telemedicine systems, diabetologists also highlighted the lack of knowledge of the telematic tools available on the market potentially usable immediately. For this reason our scientific societies (AMD-SID-SIE) have taken on the burden to collect from the companies that have responded to our request, the information on their remote medicine systems trying to classify them in a neutral but homogeneous way, in a matrix of technological characteristics able to describe the characteristics of each product. KEY WORDS telemedicine; diabetes mellitus; COVID-19.
ВЛИЯНИЕ ГОРОДСКОЙ СРЕДЫ НА ЭМОЦИОНАЛЬНУЮ СФЕРУ ПОДРОСТКОВ
Authors: Сердюкова Е.Ф.
Published: May 2021

Проживание в городских условиях существенно отличается по темпу и наполненности эмоциональными переживаниями от проживания в сельской местности. Очевидно, что и влияние на эмоциональные состояния людей, и тем более подростков, городская среда будет оказывать иное по сравнению с сельской средой проживания. При этом очевидно, что условия проживания в городе оказывают серьезное влияние на подрастающее поколение жителей, формируя у них особую, специфическую систему жизненных ценностей. Однако при анализе научной литературы по данной проблеме системных исследований эмоциональной сферы подростков, проживающих в городских условиях, выявлено не было. В статье приводятся результаты исследования, целью которого было сравнение влияния городской и сельской среды на эмоциональное состояние подростков как наиболее неустойчивой в эмоциональном плане категории жителей. Выявлены существенные различия по показателям «самочувствие» и «тревожность».
ПЛАТОН МНЕ ДРУГ, НО ИСТИНА ДОРОЖЕ (АРИСТОТЕЛЬ): ОБ ОДНОЙ ВЕРСИИ, СВЯЗАННОЙ С МЕСТОМ РОЖДЕНИЯ БЕЙБУЛАТА ТАЙМИЕВА
Authors: Дадашев Р.Х.
Published: May 2021

В статье рассматривается одна из нескольких версий, связанных с местом происхождения Бейбулата Таймиева. Указывается на существовавшее ранее предположение, озвученное А.С. Сулеймановым и Л.Н. Колосовым, о связи Б. Таймиева с селом Хочи-Ара современного Ножай-Юртовского района ЧР. Предположение основано на существующих местных топонимах. Указывается на ошибочность этой версии посредством идентификации реальной личности, имя которой отразилось в местных названиях.
ЭНЕРГОСБЕРЕГАЮЩИЙ СПОСОБ БЛАНШИРОВКИ И СУШКИ ПЛОДОВ, КОРМОВЫХ БРИКЕТОВ
Authors: Баитаев М.О. , Чербиев Л.-А.А. , Динаев А.З.
Published: May 2021

Сушка плодов или кормовых брикетов – достаточно энергозатратный способ их заготовки. Сушка – это способ консервирования, при котором сохраняются и питательные вещества, и витамины. Предложенный нами способ является эффективным в плане сбережения энергии.
The Effects of Assigning Homework on the Achievement of Students at the Primary School Level
Authors: Bakht Jamal  , Dr. Syed Asad Abbas Rizvi
Published: May 2021

Assigning homework to students make they are learning more effective and they comprehend the assigned task in depth by applying drill and practice activities. The current study examines the effects of assigning homework on the achievement of students at the primary level. The population of the study was 100 boys’ primary schools. The sample respondents of the study were students of class 5th consist of a total of sixty students and each group such as experimental, comparison, and control group was twenty students. The experimental, comparison and control groups of the students were selected by the flipping of the coin as to which will be experimental, comparison, and the control group. The researcher adopted a simple random sampling technique. The data were collected through pre and post-standardized achievement tests based on mixed items (mix tests) developed by the researcher. The researcher developed fourteen lesson plans to teach the fourteen lessons. The pre and post standardized achievement tests were conducted, collected, and evaluated under the supervision of the researcher. Data were analyzed in the form of one-way ANOVA to find out the significant difference in f-value and p-value of the experimental, comparison, and control group regarding the 14 selected topics taught. The research concluded that there was no statistically significant difference in p-value and f-value in the achievement of the students in experimental, comparison, and control group from the lessons 1-6 due to repetition and diffusion in lessons and there was a statistically significant difference in p-value and f-value in experimental, comparison and control group from the lessons 7-14 taught. The data were presented in the form of tables.
Local Perception about Caesarian Section among Post Caesarian Section Women in Pakistan
Authors: Ikram Badshah  , Zakiya Rubab Mohsin  , Jan Alam
Published: May 2021

Birthing is a critical moment in the life of a mother. The biomedical practice of the Caesarian Section (C-section) does not exist in a vacuum but is under the influence of the sociocultural environment. However, deciding between methods of birth and the perception about the C-section shows a gap and dearth in the present literature. This paper aims at understanding what social and cultural factors construct the perceptions and experiences of the Caesarian Section among post-C-section- women belonging to different socio-economic statuses. Moreover, it explores how these factors influence Pakistani women’s decision-making regarding childbirth methods. The paper uses a qualitative yet multi-sited locale approach, employing semi-structured interviews from 20 post-C-section women mainly from Islamabad and Rawalpindi region; 10 women belong to lower socio-economic status whereas, 10 to the upper one. Different themes from data were identified and obtained for analysis.

The perception and experience of the C-section fluctuate with social, economic, and cultural factors. The influence of biomedical and intra-household politics on the decision of C-section is much conspicuous and evident. Affluent families practice C-sections under dominant power dynamics without any reasoning. For those who can afford C-section, is perceived as a luxury and artificial motherhood in the eyes of ‘’the others’’ whereas, normal birthing was true and natural motherhood. The social construction of the C-section suggests that social and cultural forces play a decisive role. C-section is only acceptable if there is an emergency otherwise natural birth is the most suitable method of childbirth. Along with advocating C-sections in critical medical conditions, an awareness campaign against C-sections is also imperative for it has severe consequences.
Загострення соціальних ризиків в Україні в контексті пандемії COVID-19
Authors: Підлипна Р. П.
Published: May 2021

Систематизовано передумови виникнення соціальних ризиків в Україні, охарактеризовано основні проблеми перерозподілу ресурсів. Показано, що недостатність нормативно-правового регулювання якості надання соціальних послуг ускладнює контроль за ефективністю видатків на соціальні заходи. Виявлено, що нестабільність економічної ситуації в Україні, підсилена впливом пандемії Covid-19, призвела до зростання ризиків смерті значної частини українських громадян, інвалідізації чи довготривалої втрати працездатності, значного зростання матеріальних затрат на лікування, зростання рівня безробіття (у т.ч. прихованого) та погіршення соціально-економічного забезпечення працівників. Проаналізовано загальну і структурну динаміку видатків Державного бюджету, відзначено зростання видатків на соціальний захист населення та охорону здоров'я. Показано, що аналогічна тенденція структурної динаміки витрат соціального спрямування зумовлена намаганням інституційної підтримки населення в умовах пандемії. Водночас, виявлено зміни в програмах соціального захисту населення, які свідчать про зменшення фінансування окремих соціальних програм та додаткову бюджетну підтримку Пенсійного фонду України. Критично проаналізовано доцільність витрат коштів Фонду боротьби з Сovid-19, виявлено понад 37 % нецільового спрямування коштів. З огляду на загрозливу динаміку третьої хвилі пандемії, що проявилась стрімким зростанням добової кількості інфікованих і померлих внаслідок захворювання Covid-19 та тенденцією до зменшення віку нових хворих, досліджено можливості і перспективи імунізації населення як основного інструменту боротьби із пандемією, доведено, що недостатність коштів можна було компенсувати шляхом ефективнішого спрямування витрат Фонду. Окреслено інші соціальні ризики, зокрема проаналізовано тенденції зростання безробіття в умовах карантинних обмежень.
聚合碱性调理肥料对酸性田辣椒及病害抑制的效应
Authors: 丁 万华
Published: May 2021

在种植辣椒地上，以常规施肥为基础，进行聚合碱性调理肥料不同量小区试验及展示对比，研究其对辣椒及病害防控的效应。试验展示结果：辣椒施聚合碱性调理肥料对生长发育、增产增收及控病效果显著，其中施2100kg/hm2效果最好，施达2625kg/hm2效果下降；施1575 kg/hm2 以上防控辣椒病害明显。施2100kg/hm2产量58069.7kg/hm2、净效益468325.0元/hm2，产量比处理1、2、3、5分别增长46.0%、29.2%、16.1%、2.0%，差异极显著；净效益分别增长47.6%、30.4%、16.8%、2.4%。展示对比结果与小区试验效果相似；聚合碱性调理肥料施用量以2100kg/hm2为适宜，建议我国南方同类地区可参考应用。
ANALISIS PENGENDALIAN QUALITAS PRODUK DENGAN METODE SQC (STATISTICAL QUALITY CONTROL)
Authors: Kristanto Mulyono  , Yeni Apriyani
Published: May 2021

Didalam perusahaan diperlukan penerapan system pengendalian kualitas yang tepat untuk memperbaiki kualitas produk, mengurangi jumlah cacat produk (defect) serta dapat meningkatkan kepuasaan terhadap pelanggan. Pada PT. Sentral Bra Makmur ditemukan beberapa defect tertinggi yang menjadi permasalahan kualitas produk tidak sesuai standar. PT. Sentral Bra Makmur merupakan perusahaan yang bergerak dibidang textile yang memproduksi spesialis pakaian dalam wanita. Tujuan pada penelitian ini adalah untuk menganilisis proses pengendalian kualitas pada PT. Sentral Bra Makmur dan mengetahui seberapa besar produk cacat yang terjadi pada proses produksi, serta menganalisis faktor penyebab cacat. Metode yang digunakan dalam penelitian ini adalah metode SCQ (Statistical Quality Control), yang dilakukan dalam 4 (empat) tahapan yaitu, tahapan pemeriksaan dengan menggunakan lembar pemeriksaan atau (check sheet), menghitung dengan peta kendali, identifikasi defect dengan menggunakan diagram pareto (patero analysis) dan pemecahan masalah dengan analisis diagram sebab akibat (cause and effect diagram) hasil penlitian pada tahap deskripsi lembar Chceck sheet ditemukan jumlah produk bagus yang diperiksa sebanyak 34.260 pcs dengan jumlah defect sebanyak 3.722 pcs dan persentase sebesar 10.95%. dengan perhitungan peta kendali pada data sebagian benda diluar peta kendali. Kemudian dengan menggunakan diagram pareto ditemukan beberapa defect tertinggi yaitu benang panjang, soil/kotor. Puckering/kerut dan jahitan loncat/skipped stitches. Dan diagram sebab akibat atau diagram fishbone dapat diketahui bahwa faktor utama kegagalan produk adalah faktor manusia dan faktor mesin. Dana melakukan perbaikan yang dapat digunakan, yaitu memberikan pelatihan terhadap operator serta meningkatkan penjadwalan dalam perawatan mesin.
Upaya Meningkatkan Kompetensi Guru Dalam Menyusun Rencana Pelaksanaan Pembelajaran Melalui Bimbingan Berkelanjutan Di SD Negeri 05 Popayato Barat Gorontalo
Authors: Mada Alce
Published: May 2021

Dalam pelaksanaan pembelajaran seringkali guru dihadapkan dengan berbagai
permasalahan. Masalah yang paling utama adalah masalah pembelajaran,
dimana perolehan hasil belajar siswa di akhir pembelajaran tidak sesuai dengan
tujuan pembelajaran yang telah direncanakan di awal pembelajaran. Ttujuan
penelitian ini adalah untuk memperoleh gambaran peningkatan kompetensi
guru dalam menyusun Rencana Pelaksanaan Pembelajaran (RPP) di SD Negeri
05 Popayato Barat melalui pelaksanaan bimbingan berkelanjutan. Penelitian
ini berbentuk Penelitian Tindakan Sekolah (School Action Research), yaitu
sebuah penelitian yang merupakan kerjasama antara peneliti dan guru, dalam
meningkatkan kemampuan guru agar menjadi lebih baik dalam menyusun
rencana pelaksanaan pembelajaran. Yang menjadi subjek penelitian tindakan
sekolah ini adalah guru-guru di SDN 05 Popayato Barat yang berjumlah 5
Guru. Pada data awal rata – rata komponen RPP hanya mencapai 55,36%
(kurang baik), pada siklus I terjadi peningkatan 21,43% sehingga nilai rata-rata
komponen RPP telah mencapai 76,79% (Baik). Sedangkan pada siklus II nilai
rata-rata komponen RPP menjadi 91,07% (sangat baik), hal ini berarti telah
terjadi peningkatan sebesar 14,28% dari siklus I. Hal ini dirasa sudah cukup
memuaskan karena kriteria keberhasilan yang telah ditentukan sudah tercapai
yaitu persentase kenaikan skor kompetensi guru dalam merancang RPP dan
melaksanakan pembelajaran mencapai 80%
NT DISOC 90 - A Nova Metodologia de Reajuste dos Planos de Saúde Medirá os Custos, os Preços e a Eficiência das Operadoras?
Authors: Fiuza Eduardo Pedral Sampaio , Marinho Alexandre , Ocké-Reis Carlos Octávio
Published: May 2021

A Agência Nacional de Saúde Suplementar (ANS) aprovou uma nova metodologia de cálculo do reajuste dos planos de saúde individual e familiar em 19 de dezembro de 2018. A regulação dos preços é necessária em vista das várias falhas de mercado presentes nesse setor: demanda induzida, risco moral, externalidades – por exemplo, no caso do tratamento de doenças infectocontagiosas –, entre outras (Cutler e Zeckhauser, 2000; Ocké-Reis e Cardoso, 2006). Também na medicina se verifica a chamada “doença dos custos” (Baumol, 1993, p. 19), que conduz a uma apreciação histórica dos serviços de saúde em relação a outros bens e serviços de consumo.

Nosso objetivo é compreender os pressupostos teóricos dessa metodologia, tendo em mente o exame da sua capacidade de medir a evolução dos custos e preços desse segmento, bem como de mensurar a eficiência das operadoras em funcionamento no mercado de planos de saúde brasileiro

Cabe assinalar, a agência reguladora não fez aparentemente qualquer avaliação de impacto dessa nova regra2 – por exemplo – a partir dos dados de desempenho das operadoras observados no passado, o que nos deixou reticentes para construir cenários empíricos, a partir da utilização dos microdados da ANS. De fato, como os microdados das operadoras não estão disponíveis para nós, nenhum exercício empírico foi realizado nesta nota técnica (NT).

Nessa linha, dividimos este trabalho em quatro seções, além desta introdução. Na seção 2, faremos uma breve retrospectiva das alternativas regulatórias avaliadas pela ANS. Na seção 3, questionamos algumas dimensões técnicas assumidas pela nova metodologia, em especial seu modelo de regulação por desempenho e o fator de ganhos de eficiência (FGE) – equivalente ao chamado fator X dos modelos de regulação por teto de preços (price cap).3 Na seção 4, além de apontar lacunas presentes no debate, sugerimos uma abordagem mais ousada para se regular o setor de saúde suplementar, que requereria uma quebra de paradigma e uma conciliação dessa regulação com a do próprio Sistema Único de Saúde (SUS). Na seção 5, resumiremos as principais conclusões deste trabalho.
Design and Simulation of Ti6Al4V Cartilage Scaffold Based on Additive Manufacturing Technology
Authors: Gao Han Jun , Yuan Hao , Xia Jian Qiang , Li Hong Wei , Zhang Yi Du
Published: May 2021

The combination of additive manufacturing technology and cartilage tissue scaffold construction provides a new way for clinical treatment of cartilage injury. The high priority of the cartilage scaffold is closely related to the excellent biomechanical properties, fatigue life and medical performance. In this paper, three kinds of cartilage scaffolds are designed, and three-dimensional parametric geometric and numerical simulation models are established. Based on the simulation analysis and comparison of the three kinds of scaffolds, a scaffold model is finally determined. The porosity reaches 87.38%, the equivalent elastic modulus is 9.64Gpa, and it has permanent fatigue life in service environment. It concluded that the designed Ti6Al4V titanium alloy scaffold is suitable for cartilage transplantation.
Anisotropy of Microstructure and Tensile Properties of Additive Manufactured ZTC4 Alloy
Authors: Wei Zhen Wei , Xing Wei Jie , Chen Bing Qing , Jiang Tao
Published: May 2021

ZTC4 alloy prepared by electron beam melting was hot isostatically pressed, the macro-and microstructure were characterized by stereo microscopy and optical microscopy, the tensile properties were tested and the fracture profiles were characterized using scanning electron microscopy. The results show that: The vertical deposition samples exhibit coarsen epitaxial columnar grains and the parallel samples show equiaxed grains, and microstructure are basket-weave α+β phase. The vertical deposition samples exhibit very high ultimate tensile strength and yield strength but poor ductility with elongation and shrinkage, and show generally more planar and faceted fracture morphology. The anisotropy in tensile properties is mainly due to the difference in the orientation of the columnar grains with respect to the tensile test direction, and the characteristics of the minor fracture plane are mainly related to the α colonies.
Effect of Annealing Process on Microstructure and Tensile Properties of TC16 Titanium Alloy after Rapid Heat Treatment
Authors: Lei Peng , Dong Shu Cheng , Ma Guang Yu , Cheng Tuo , Ivasishin O.M.
Published: May 2021

TC16 titanium alloy is a martensite α+β two-phase high strength titanium alloy, which can improve its structure and enhance properties through heat treatment. Effect of annealing process on microstructure and tensile properties of TC16 titanium alloy was investigated using optical microscope, scanning electron microscope and universe tensile test machine. The results show that when annealed at 720°C for 4h then furnace cooling to ambient temperature, the tensile strength of the TC16 alloy reaches nearly 900MPa,the elongation reaches 19.6% and the reduction of area reaches 65%, which present a good comprehensive performance.
Crack Analysis of Casting Stainless Steel Support
Authors: Yu Yan Yan , Song Ti Jie , Lu Zeng Wei
Published: May 2021

A crack is found on the surface of stainless steel casting support. The crack was analyzed by macro and micro observation of fracture surface, Energy Dispersive Spectrometer (EDS) analysis, chemical analysis, microstructure examination and hardness test. Moreover, the stress distribution was simulated by finite element analysis. The results show that the crack model of the support is stress corrosion. The stress at the crack location is the largest. Three main factors of stress corrosion were the crack of paint layer, marine atmospheric environment and the pretightening force for the support. Because the service environment cannot be changed, therefore, surface paint protective effect and reduction of preload can be improved to avoid stress corrosion cracking again on the support.
Synthesis, antimicrobial activities and GAPDH docking of novel 1, 2, 3-triazole derivatives
Authors: Alkhaldi Abdulsalam A.M. , Abdelgawad Mohamed A. , Youssif Bahaa G.M. , El-Gendy Ahmed O. , De Koning Harry P.
Published: May 2021

Purpose: To synthesize new triazole derivatives in order to overcome the problem of side effects of antimicrobial agents and microbial resistance, while broadening the spectrum of antimicrobial activity.

Methods: The starting triazole, compound 1, was prepared through click chemistry and reacted with chloroacetyl chloride to yield compound II. Triazole 1 was reacted with acids and aldehydes to produce oxadiazole (III) and azomethine (IV) which cyclized in acetic anhydride to give a new acetylated oxadiazole (V). Minimum inhibitory concentration (MIC) and resorufin assays were used for antibacterial and anti-parasitic screening, respectively. Compounds II and IVb were subjected to molecular docking studies using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Molecular Operating Environment (MOE) program.

Results: Novel oxazole-triazole derivative (III) showed high activity against Pseudomonas aeruginosa and moderate activity against Staphylococcus epidermidis, whereas compound IVc showed moderate activity against Staphylococcus epidermidis. Chloro-acetyl-triazole II and 2-hydroxyphenyl-triazole Schiff base (Ivb) showed pronounced activity against the kinetoplastid parasites, Leishmania major, Leishmania mexicana and Trypanosoma brucei.

Conclusion: The new synthesized triazoles represent a new antimicrobial scaffold and identifies potential new lead compounds for follow-up and for further mechanistic studies.
Sevoflurane and fentanyl exert protective effect on cognitive function in aged rats via regulation of inflammatory response in the brain
Authors: Zhao Xin , Li Peixiang
Published: May 2021

Purpose: To investigate the effects of sevoflurane and fentanyl on cognitive function in aged rats, and to determine the mechanism of action.

Methods: A total of 160 adult male Wistar rats were randomly assigned to four groups of 40 rats each. With the exception of control, the rats were surgically operated on. Sevoflurane group received sevoflurane (2 %) via inhalation for 2 h/day for 7 days, while the fentanyl group received fentanyl (50 µg/kg body weight) for 1 h via their tail veins for 7 days. The cognitive function of the rats was evaluated by shuttle box and Morris water maze (MWM) tests, while interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and tumor necrosis factor α (TNF-α) were evaluated using ELISA kits.

Results: The learning and memory latencies of the rats were significantly prolonged in surgery, with prolongation greater in sevoflurane and fentanyl groups than in control group; however, the latencies were significantly shorter in sevoflurane and fentanyl groups than in surgery group (p < 0.05). The levels of VEGF, IL-6 and TNF-α were significantly higher in the surgery, sevoflurane and fentanyl groups than in control group (p < 0.05).

Conclusion: Sevoflurane and fentanyl improve cognitive function in aged rats via a mechanism involving the regulation of inflammatory response in the brain.
Mutagenesis, ‘essentially biological processes’ and patent exceptions
Authors: Lightbourne Muriel
Published: May 2021

Recent developments in the field of European law, in relation to subject-matter consisting of living material, raise a string of basic issues as to the legal qualification of certain techniques used in agriculture and medicine, such as CRISPR-Cas9, and regarding their appraisal under European patent law. The present article reviews a series of decisions, including the decision of the Court of Justice of the European Union in case C-528/16, the decision issued on 7 February 2020 by the French Council of State and the Opinion of the European Patent Office Enlarged Board of Appeal of 14 May 2020 on Referral G 3/19.
PARTILHA DE CUIDADO ENTRE FAMILIARES APÓS A HOSPITALIZAÇÃO INFANTIL
Authors: Soares Fernandes Talitha Sonally , Da Cruz Amorim Rita , Cabral de Carvalho Rosely
Published: May 2021

OBJETIVO: Conhecer os modos de partilhar o cuidado à criança entre familiares, no domicílio, após a alta hospitalar. METODOS: Estudo descritivo e exploratório, com abordagem qualitativa, referenciada na Teoria Bioecológica do Desenvolvimento Humano e na Inserção Ecológica. Participaram sete famílias que foram acompanhadas no Hospital e, após a alta, em seus domicílios. RESULTADOS: A transição hospital-casa e o seguimento do cuidado revelam potencialidades e fragilidades que transcendem a doença, com a presença de sentimentos ambivalentes, como alívio por deixar o hospital, mas, ao mesmo tempo, preocupação com recaídas e necessidade de reinternação. CONSIDERAÇÕES FINAIS: Os modos de partilhar o cuidado às crianças, após a hospitalização, ocorrem de maneira singular às necessidades da criança e de cada família, a depender do contexto domiciliar, as pessoas envolvidas, suas histórias e rotinas estabelecidas no decorrer do tempo, bem como reflexões e interpretações do processo.
Kopint-Tárki Zrt.: Lassú lesz a kilábalás a pandémiás időszakból
Authors: Nagy Katalin , Matheika Zoltán , Palócz Éva
Published: May 2021

A globális növekedésre vonatkozó 2021-es előrejelzések meglehetősen optimisták: 5,6-6 százalék körüli növekedést várnak. Ez az optimizmus elsősorban azon alapszik, hogy az átoltottsággal a pandémia fokozatosan enyhül. A Kopint-Tárki ennél nagyobb kockázatokat lát, különösen annak fényében, hogy az egyes országok növekedésére vonatkozó prognózisokat az elmúlt hónapokban jellemzően csökkentették, mivel a járványból való kilábalás akadozik és bizonytalan. Ugyanez a bizonytalanság nyomja rá a bélyegét a magyar gazdaság idei kilátásaira. A Kopint-Tárki 4,5 százalék körüli idei GDP-növekedést vár, amelynek a húzóereje a beruházások élénkülése és a nettó export javulása lehet. A háztartások fogyasztására egyfelől az elhalasztott kereslet, másfelől a továbbra is óvatos költési hajlandóság nyomja rá a bélyegét.
A FUNCIONALIDADE DAS SALAS DE ATENDIMENTO EDUCACIONAL ESPECIALIZADO NAS ESCOLAS DE ENSINO FUNDAMENTAL
Authors: Souza Joniery Rubim de , Silva Maria Iris Mendes da
Published: May 2021

A educação inclusiva é um assunto de ampla discussão atual que envolve aspectos políticos, culturais, sociais e pedagógicos. Tendo em vista os diversos debates acerca de todas as particularidades que compõe essa temática, o presente trabalho tem como objetivo compreender o funcionamento dos espaços para atendimento educacional especializado nas escolas do ensino fundamental no município de Caxias-MA, no que se refere ao atendimento à demanda local, bem como saber se as práticas desenvolvidas nas  Salas de Recursos Multifuncionais (SRM) atendem as necessidades educacionais especiais dos alunos e quais conhecimentos os professores possuem quanto ao trabalho que deve ser realizado nesses ambientes de educação inclusiva. A pesquisa se classifica como de natureza básica, com abordagem metodológica de caráter quanti-qualitativo e estudo de campo. Sua execução foi dividida em três etapas, obedecendo a seguinte ordem: levantamento de dados sobre as escolas que ofertam atendimento educacional especializado aos alunos matriculados, aplicação de questionários com os professores das SRM e profissionais de Atendimento Educacional Especializado (AEE), e posterior processamento de dados para obtenção de resultados que subsidiaram a pesquisa. Ao final deste estudo obteve-se um panorama do funcionamento das salas de AEE nas escolas de ensino fundamental da cidade de Caxias-MA.
ANNEALING TEMPERATURE ENHANCED THE CONVERSION EFFICIENCY OF (ITO/ZNO/CUO) HETEROJUNCTION
Authors: ABDULLH Anas A , HASSAN Bakr F , AHMED Rasha H
Published: May 2021

Copper oxide (CuO) thin film was deposited on glass substrates using pulsed laser deposition by fundamental wavelength (1064 nm) Q-switched Nd:YAG laser with 900 mJ peak energy at RT and annealed at 200 and 300 ᴼC respectively. The Structural and optical properties of the prepared copper oxide thin films were studied using X-ray diffraction (XRD) and energy UV-visible spectroscopy. The copper oxide films exhibited Cu2O phase of cubic structure converted gradually to CuO in a monoclinic crystal structure when annealed to 300 ᴼC. Direct energy gap 2.25 eV value at RT sample, While the annealed samples have 1.8 and 1.6 eV indirect transitions. The I-V Characteristics of the ZnO/CuO heterojunction were studied under illumination revealed that the fabricate samples exhibit photovoltaic properties. The best efficiency appeared at 200 ᴼC annealing temperature
Kebijakan Pembelajaran Jarak Jauh Dalam Perspektif Orang Tua Di Madrasah Ibtidaiyah
Authors: Murodah Nelli
Published: May 2021

This study is qualitative research that aims to analyze the policy of distance learning in the perspective of parents in madrasah ibtidaiyah. The data was collected with in-depth interviews, participatory observations, and documentation studies. Data analysis using interactive analysis models put forward by Miles and Hubermen. The results showed that parents' perception of the application of distance learning policy in madrasah ibtidaiyah can be said to be different. Some say agree, some disagree, and others disagree. Those who agree say that distance learning is effective, while those who disagree state that distance learning is less effective, not even effective to do.
INTEGRAL TEACHING PATH: THE MAIN ASPECTS OF USAGE IN THE SCIENCE EDUCATION PROCESS
Authors: Railienė Laima
Published: May 2021

The main aim in the environment of the teaching events is to develop and consolidate the abilities, widen students’ outlook, deepen their theoretical knowledge.
Students learn to know all the world’s special variety in class, auditorium. Beside school, in students’ living place or further environment there is suitable site where students cannot only deepen their knowledge, but also they can show their creativeness, ability to work in a team, help each other. It develops students’ motivation, natural science competence.
Integrated teaching path where students and teachers work together, can be also called a specialized path, because here you can do tasks, deepen your theoretical knowledge, consolidate abilities. It can be used not only in geography lessons. Such a specialized path can perfectly serve for studying biology, chemistry, physics.
It is important to foresee the right place and use the right methods for a specialized path. Nowadays information communication technologies are closely connected with the teaching process in a secondary school. It helps to prepare a teaching path more creatively, more picturesquely. It is also possible to use the newest navigation appliances. The same, IST help to perform teaching path’s dispersion.
Key words: integrated teaching path, specialized path, navigation appliances.
HEAT DISSIPATION AT CEMENT HARDENING
Authors: ZHUMADILOVA ZHANAR , AKMALAIULY KENZHEBEK
Published: May 2021

During the construction of concrete structures of small cross-sections, the release of heat during cement hardening has no harmful effects. With the increasing temperature of the hardening cement mass, the rate of cement hydration increases. This increases the rate of release of its heat of hydration of cement. The consequence of the accelerated process of hydration of the binder is a more intensive increase in the strength of cement stone than in the case of hardening under normal conditions. This fact is widely used in practice for the intensification of the hardening of concrete. When structures with small cross-sections are being built, the heat released during hardening is relatively quickly transferred to the surrounding space and does not cause a significant increase in temperature. In structures made of massive concrete (with a large cross-section), this heat is stored in the interior of the array for a long time, which causes a rather large rise in temperature and its slow drop. This is due to the fact that heat transfer to the external environment is hampered here by the considerable thickness of the massif and the rapid rate of concreting, mechanized laying of large masses of concrete. As a result, a temperature difference is created between the internal and external parts of the structure and harmful internal stresses arise that can cause cracking in the hardened concrete. This leads to a violation of its solidity. The faster cement hydrates, the sooner and more heat is released. The types of cements with a high content of tricalcium silicate and aluminate emit more heat and rather than types of cement with a high content of dicalcium silicate and tetra-calcium aluminoferrite. However, the latter has a lower strength. The increase in strength resulting from the hydration process is inevitably associated with the release of heat into the environment.
STUDY ON THE DPPH FREE RADICAL-SCAVENGING ACTIVITY OF SALVIA NEMOROSA L. AT TWO GROWTH STAGES
Authors: GHAFIYEHSANJ Elham , DILMAGHANI Kamaladdin , CHAPARZADE Nader , SAADATMAND Sara
Published: May 2021

This study was designed to examine the DPPH free radical-scavenging activity, in different concentrations (0.025, 0.05, 0.07, 0.1, 0.2, 0.04 and 0.6) of methanolic extracts of Salvia nemorosa L. collected from the northwest of Iran (Zonouz and Ardabil regions) at two-stage of growth (vegetative stage leaves, flowering stage leaves, and flowers). The result showed that the mean of inhibition percentage in the Zonouz region increased in various concentrations and between flowers, vegetative stage leaves, and flowering stage leaves, compared with the plants of the Ardabil region. In each of the regions of Zonouz and Ardabil, the highest amount of DPPH inhibition was observed in the vegetative stage leaves in comparison with flowering stage leaves and flowers. In addition, in the effect of DPPH radical trapping in different concentrations of methanolic extracts of Salvia nemorosa L. was observed that from each of the collected region, methanolic extracts from sage plants were dose-dependent and acted very effective and useful and the best antioxidant activity was in the high concentration of extracts, So in Zonouz and Ardabil regions, the content of inhibition of DPPH increased significantly, by increasing the concentration of 0.025 mg/ml to 0.6 mg/ml and in Zonouz region the content of inhibition of DPPH similarly increased in 0.2, 0.4 and 0.6 mg/ml concentrations. In the Ardabil region, the most content of inhibition of DPPH was seen in 0.4 mg/ml and 0.6 mg/ml concentrations, but in this region, the content of inhibition of DPPH in 0.2 mg/ml concentration there was only in vegetative stage leaves and flowering stage leaves.
Inclusión y Desarrollo Social en la agenda y los planes de Ciencia, Tecnología e Innovación de Brasil y Uruguay (2003-2015)
Authors: Cirino Gabriela , Davyt Amílcar
Published: May 2021

Se pretende contribuir a la reflexión sobre cambios y continuidades de las políticas de Ciencia, Tecnología e Innovación en Latinoamérica, buscando entender los efectos de la introducción, en las prácticas políticas recientes, de modelos que vinculan la CTI con los problemas de inclusión y desarrollo social. Para ello, se analizan comparativamente las experiencias de generación de planes estratégicos de CTI de Brasil y Uruguay en el periodo 2003-2015. Luego de presentar las principales concepciones teóricas sobre políticas CTI, se analizan las formas en que se aborda el tema de la inclusión y el desarrollo social en los estudios, propuestas, planes y estrategias nacionales de CTI en cada país. Se analizan, después, los instrumentos de política y presupuestos implementados en el periodo. Finalmente, se comparan ambos procesos, destacando las similitudes y diferencias detectadas. Se concluye que el contexto político favorable para la incorporación del tema de CTI para la inclusión y el desarrollo social, propiciado por la asunción de gobiernos progresistas y la incorporación en sus agendas de dichos temas como fundamentales, no fue suficiente para consolidar una política efectiva y duradera en la materia, más allá de su incorporación en el discurso, en documentos oficiales y en planes de ambos gobiernos.
Reliability analysis of load and pain assessment using the SORRI® monofilaments in patients with migraine
Authors: Grunewald Jaqueline Nisa de Cássia , Gonçalves Maria Claudia , Florencio Lidiane Lima , Carvalho Gabriela Ferreira , Fonseca Marisa de Cássia Registro , Dach Fabíola , Grossi Débora Bevilaqua
Published: May 2021

The objective was to evaluate allodynia and verify the reliability of the pain response and the actual load applied by monofilament SORRI® in patients with migraine and to identify the relationship between these variables. We evaluated 40 women , 20 migraine group (GM) and 20 control group (CG) aged 18-55 years in two assessments of sensitivity with an interval of 15 minutes in five regions: Front and masseter muscles bilaterally and right forearm. We also applied the technique of brush and only the GM Questionnaire-12 ASC Brazil. To check the actual load monofilaments were coupled to the load cell of the Electronic von frey IITC Life Science Inc.. In GC 10% reported pain with the application monofilament and GM 70%, 7% of these were classified as mild allodynia, 35% moderate and 57% severe allodynia and 35% also reported pain in the brush technique. The reliability of pain assessment was calculated by correlation index Kappa and a variation was observed concordance of poor to moderate (0.167 to 0.692) in GM and there was no change in GC. The reliability of the actual load applied was calculated by Intraclass Correlation Coefficient (ICC) and demonstrated that all monofilament showed a variation between poor to excellent. We observed a change in load in relation to the pre-set 150% monofilament green, 0 to 50% for the blue and from 0.5 % to 25 % for purple and red and orange. The reliability of freight and reporting pain of monofilament of SORRI® are variable and therefore should not be used as the only tool in the evaluation of the sensitivity of the face of patients with migraine.
Topiramate and cognitive function: review
Authors: Santos Karllus Andhre Leite de Mendonça , Martins Hugo André de Lima , Ribas Valdenilson Ribeiro , Lima Louana Cassiano Silva , Santos Camila Cordeiro dos , Oliveira Daniella de Araújo , Valença Marcelo Moraes
Published: May 2021

Despite the therapeutic efficacy, in its various indications, cognitive side effects are common findings with topiramate. Descriptive studies indicate nonspecific complaints cognitive, psychomotor slowness and language difficulties, as main complaints among patients who had to discontinue use of the medication, even when it shows efficacy in symptomatic control of the patient. Even in patients who do not have cognitive complaints topiramate-related, changes were found in the performance of psychometric tests. The negative cognitive effects induced by topiramate are often temporary and cease after its discontinuation. There appears to be certain conditions associated with an increased risk for the development of side effects such as titration scheme, the dose used, maintenance time polytherapy and individual susceptibility. The mechanism in which topiramate leads to cognitive impairments is still poorly understood. Neurophysiology and functional neuroimaging studies seeking to elucidate the question. The magnitude of the cognitive changes may be enough to interfere with school performance, work and social relationships and are among the leading causes of discontinuation of medication during treatment.
Headaches and the quality of life in adolescents
Authors: Silva Bruno Rafael Vieira Souza , Silva Alison Oliveira da , Diniz Paula Rejane Beserra , Valença Marcelo Moraes , Silva Ladyodeyse da Cunha , Santos Carolina da Franca Bandeira Ferreira , Oliveira Luciano Machado Ferreira Tenório de
Published: May 2021

Headache is a common problem in the general population and, in particular, in children and adolescents and may negatively influence the quality of life of young. Thus, this study aimed to analyze, through a systematic review, the epidemiology of headache and association with the quality of life of adolescents. Initially, a search was conducted in the databases PubMed, Lilacs and Scielo using the keywords "epidemiology", "headache", "quality of life", "adolescents". Data were analyzed by two researchers independently. Were selected, after applying the inclusion criteria, 10 articles. Was observed that headache can cause a substantial impact on physical and mental health of adolescents, mainly among females. There is a shortage of longitudinal research and studies involving children with headache. In addition, the headache was related to emotional disturbances, depression, anxiety and difficulties of interaction related to family and school, which may cause a departure from the everyday activities and consequently decrease the quality of life of those suffering from headache.
Compensation for assets without a market in the remedial acquisition pursuant to art. 42-bis of Presidential Decree 327/2001 [Stima dell’indennizzo per beni senza mercato nell’acquisizione sanante ex art. 42-bis del DPR 327/2001]
Authors: Manganelli Benedetto
Published: May 2021

The estimated compensation provided for damage to property deriving from the remedial acquisition pursuant to art. 42-bis of the Consolidated Law on Expropriations (Presidential Decree 327/2001), raises some questions both of a general and an applicative nature. This study, on the one hand, defines the contours of the estimation problem so as to frame it within the principles and postulates of the doctrine, and on the other, it pro-vides the operational indications that are necessary to face the practical determination of the compensation.The two are obviously closely connected. The discussion and the conclusions provide food for thought on issues involving the real estate appraisal and the legislation on expropriation.
Ocupações informais e direito à água no contexto da Covid-19: análise das vulnerabilidades hídricas nas bacias hidrográficas do DF em uma visão ecossistêmica da saúde
Authors: Andrade Liza Maria Souza de , Lenoir Juliette Anna Fanny , Rezende Vinícius Silva
Published: May 2021

Considerando a visão ecossistêmica da saúde que abrange os direitos humanos fundamentais em que o acesso à água e ao saneamento são fundamentais e imprescindíveis para a promoção da saúde e o enfrentamento da disseminação do Covid-19, esta pesquisa relaciona as ocupações informais do DF e o direito à água e aos outros serviços de saneamento e saúde com ênfase nas tipologias habitacionais das ocupações informais que estão fora das áreas de ARIS e ARINES do PDOT, e consequentemente sem acesso ao saneamento. O objetivo é proceder a um cruzamento entre os mapas de localização das ocupações nas RAs e nas bacias hidrográficas e os mapas de risco de contágio e indicar as ocupações que mais necessitam de suprimento hídrico em caráter emergencial nas áreas mais susceptíveis a disseminações generalizadas do coronavírus utilizando dados de vários órgãos governamentais georefenciados com Shapes e Rasters no programa gratuito QGis3.10.4. Os resultados sobre o risco a saúde devido à COVID-19 demonstraram a fragilidade de regiões como Ceilândia (9.5), Taguatinga (8.5), Gama (8.25), Sobradinho (8.25) e Samambaia (8.0) como também suas fragilidades em aspectos econômicos, e, considerando os efeitos da crise econômica eminente, tais regiões administrativas demandam ainda mais atenção governamental.