bluuebunny/crossref_metadata_2025 huggingface dataset:
Internal hernia with Roux loop gangrene in a post
Authors: Ganesan Swaminathan , Devakumar Satish
Published: July 2019

High degree suspicion is mandatory in dealing with a post-operative patient presenting with a crampy postprandial abdominal pain, as potential for internal hernias remains fairly under diagnosed. Except in setting of small bowel obstruction or gangrene and radiological proven internal hernia, intervening a patient with herald symptoms is still debatable, though certain authors advocate that in lap. Roux-en Y gastric bypass patients with herald symptoms should promptly be offered elective laparoscopic exploration elective repair safely and expeditiously.
MARKETING COMMUNICATION STRATEGY OF HALAL TOURISM AROUND GUS DUR’S CEMETERY IN JOMBANG
Authors: Rohimah Afifatur , Romadhan Mohammad Insan
Published: July 2019

This article aims to develop an appropriate strategy for halal tourism at the complex of Gus Dur’s cemetery. The aim of the study is to find out an appropriate marketing communication strategy that can be applied for halal tourism particularly in religious tourism complex, around Gus Dur’s cemetery. This study used descriptive qualitative method through a mapping approach in finding the data. The finding of the study is that the implementation of an appropriate marketing communication strategy of halal tourism around Gus Dur’s cemetery should consider several aspects including advertisement role, sales promotion, event enhancement, maximizing social relationships, social publicity, direct marketing with digital utilization, and growing good tourist image with the role of word of mouth. The marketing communication strategy that will be developed should refer to the concept of halal tourism; the so called Muslim-friendly environment. Throughout this marketing communication strategy, this will maximize the existence of religious tourism around Gus Dur’s cemetery both for local and international tourists.
MAJLIS TA’LIM (ISLAMIC FORUM) AND HARMONIZING INTER FAITH COMMUNICATION
Authors: Abidin Zaenal
Published: July 2019

The process of growing multiculturalism and tolerance values among religious followers to the community in Indonesia can be done through religious lectures in majlis ta’lim (Islamic forum) in mosques, houses, meeting halls, etc. The lectures delivered were concerned about democracy, justice and law, cultural values and ethos, equality in differences, ethnicity, religious beliefs, cultural expressions, private and public domains, human rights, community cultural rights, and other relevant concepts. In this case, majlis ta’lim (Islamic forum) can be seen as a solution of growing the seeds of democracy, tolerance and multiculturalism for the harmonization among religious groups Indonesia. Majlis Ta’lim (Islamic forum) is a great potential since it can create a harmonious and free from radical values country, and able to reduce issues of SARA (ethnicity, religion, ancestry, and group of people), which are often raised from the institutionalization of community. Good understanding of democracy, tolerance and multiculturalism are aligned with the Islamic values.
POLITICAL COMMUNICATION OF ACEH GOVERNOR’S CANDIDATE IN INDONESIAN LOCAL LEADERS’ ELECTION IN 2017
Authors: Hamdani A.G
Published: July 2019

This study aims to examine the political communication of the Aceh governors’ candidate during the Indonesian local leaders’ election in 2017. The focus of the study is to analyze the political communication of the candidates and the effectiveness of the campaign. This study used a qualitative approach. The findings show that both candidates used propaganda political communication, communication techniques, and various political campaign strategies. The political propaganda strategy and campaign the governor candidate of Irwandi-Nova were far more intense, effective, widespread and comprehensive in quality and quantity compare to Muzakkir-TA. Although the candidate of Irwandi-Nova cannot predict their supporters for granted, apparently their political communication strategy, propaganda and political approach have effectively anesthetized Acehnese voters and placed them as the winner of the Aceh Governor's Election that counted for 898,710 votes while Muzakkir-TA only gained 766,427 votes.
Clinical significance of mean platelet volume/lymphocyte ratio and mean platelet volume/platelet ratio in the exacerbation of chronic obstructive pulmonary disease
Authors: Özsarı Emine , Koçak Mehmet Zahid
Published: July 2019

Objectives:
Studies
showing the role of systemic inflammation in chronic obstructive pulmonary disease (COPD)
are increasing. Particularly, importance of mean platelet volume (MPV) and
neutrophil/lymphocyte ratio (NLR) for acute exacerbation of COPD has been
reported. The use of MPV/lymphocyte ratio (MLR) and MPV/platelet ratio(MPR) in
acute exacerbation of COPD patients was investigated in our study, considering
that MPV alone may be a more valuable marker of inflammation. Methods: Between March 2017 and March 2018, COPD patients who applied to Abant Izzet Baysal
University School of Medicine, Chest Diseases outpatient clinic were examined. Results
were retrospectively scanned from patient files after institutional approval. Sixty-four
(60.4%) stable COPD and 42 (39.6%) acute exacerbation COPD patients were
included in the study. Results: Seventy-one
(67%) of patients were male and 35 (33%) were female. NLR was 2.26 (0.93-6.48)
in stable patients and 4 (1.18-36) in acute attack patients (p < 0.001); PLR was 137.44
(66.9-436.6) in patients with stable disease and 162.8 (85-1056.6) in patients
with attack (p = 0.068). MLR was 5 (2.92-25)
in acute attack patients and 4 (1.89-8.67) in stable patients; this difference was
statistically significant (p = 0.003).
MPV was found to be 7 (5.5-9.1) fL in patients with stable disease and 8
(5-13.4) fL in acute patients. This difference was statistically significant (p < 0.001). MPR was found to be
statistically significantly higher in acute patients than in patients with
stable disease (p = 0.04). WBC, neutrophil
and CRP were found to be statistically significantly higher in acute patients
than in stable patients (p < 0.05).
There was a statistically significant correlation between WBC and NLR (r =
0.269, p = 0.005) and between CRP and
NLR (r = 0.379, p < 0.001).

Conclusions: Hemogram
parameters from routine laboratory tests in COPD patients are cheap and easily
accessible. It is important to detect the presence of subclinical inflammation
in the stable phase, as well as to identify patients at risk of exacerbation. Prospective
studies are needed to demonstrate correlations with inflammatory markers.
The Effects of Biannual Equine Influenza Vaccine on Performance in Adult Horses
Authors: Shipman Emma
Published: July 2019

PICO question

In three day event horses, does biannual routine influenza vaccination compared to annual routine influenza vaccination reduce performance levels?

Clinical bottom line

There is no evidence that biannual equine influenza vaccination compared to annual booster vaccination in three day event horses is associated with reduced performance.

A group of five studies published over an 11 year period from one were evaluated. In adult warmblood horses there is weak evidence that exercise in the 28 day period post booster vaccination for equine influenza and equine herpes virus 1 and 4 (EHV1&4), is associated with changes in physical and clinical pathophysiological parameters including total red blood cell (RBC) count, neutrophil and lymphocyte count, fibrinogen concentration and serum proteins. These changes occurred at variable time points in the 14 days post exercise and values were not outside the published reference ranges for the reporting laboratories where published. Athletic performance of the horses was not evaluated.

No recommendations for equine influenza vaccination protocols in three day event horses can be made from the evidence.

 
Prevalence of Dry Eye in Patients at the FESI Optometry Clinic, UNAM
Authors: Navarro Luna Pedro , Vázquez Mendoza Alicia , Alonso Trujillo Javier , González Aragón Pineda Álvaro Édgar , Ramos Montes Óscar Antonio
Published: July 2019

Objetive: To report the prevalence of dry eye and to determine the differences between young and adult patients attending the Optometry Clinic of the Iztacala School of Higher Education at Universidad Nacional Autónoma de México (UNAM). Material and methods: In 1957, patients between the ages of 15 and 65 assessed at the “Centro de Diagnóstico de Alteraciones deSuperficie Ocular” of the Iztacala School of Higher Education of UNAM between August 2016and August 2017. The patients answered the digital version of the Ocular Surface Disease Index(OSDI) diagnostic questionnaire and the mucin arborization pattern was evaluated using the TearFerning Test (TFT). Results: The mean prevalence of the diagnosis with a significant differenceof positive P 0.05 for Ferning (59.1%) and OSDI (63.8%). Using the Ferning technique in youngpatients (15 to 29 years), it was possible to assess a prevalence of dry eye of 51.9%; whereas inadults (30 to 65 years) it was 66.9%. Using the OSDI questionnaire, the prevalence was 60.1% inyoung people and 67.8% in adults; in addition, for each year of increase in age, the probabilityof having a dry eye increased by 1% with OSDI and 2% with Ferning. Conclusions: With thisstudy, it was established, for the first time, that the young people who go to the optometry clinicof FES-Iztacala, a sector that had not been previously considered, also suffer from this disease.
El urbanismo de baja densidad en las Tierras Bajas Mayas: El caso de El Perú-Waka’, Petén, Guatemala
Authors: Marken Damien Bernard , Ricker Matthew C. , Rivas Alexander , Maxson Erika
Published: July 2019

Como ejemplos clave del urbanismo en el Nuevo Mundo indígena, las ciudades mayas son temas de gran trascendencia antropológica. A pesar de su importancia comparativa, durante gran parte del siglo veinte los centros mayas del Clásico (ca. 250-950 d.C.) han sido vistos como “no-ciudades”, capitales de entidades complejas, pero marcadas por la ausencia de una densidad característica de lugares puramente urbanos. Fletcher propuso que el urbanismo maya corresponde a un tipo urbano que denomina “urbanismo agrario de baja-densidad”; aunque, como todas las categorías tipológicas, también tiene debilidades. Este artículo presenta los resultados de más de diez años de investigación de la ciudad maya clásica de El Perú-Waka’, en Guatemala, con el fin de evaluar el modelo de Fletcher en el área maya. Los datos procedentes de Waka’ sugieren que, a pesar de que en general el modelo de Fletcher es ampliamente aplicable a las Tierras Bajas, es necesario volver a examinar diversos supuestos sobre las ciudades mayas.
Ketiadaan Otoritas Terpusat dalam Fenomena Kontemporer di Indonesia
Authors: Chairi Effendi
Published: July 2019

This article presents an analysis result on contemporary phenomenon inIndonesia by sociological approach. This states that Ulama or kiai whowere formerly the only religious authorities fused religious purity inpolitical interest. This gives negative influence for religious authorityitself. Substantive divine will is forced to submit to the will of individualor certain group. So Islam which is previously inclusive and moderatmelts to exclusive and discriminative acts. The distance betweenreligious goals to rahmatan lil-’alamin and individual political interesthas been eroded (hyper-reality). Therefore, society has not trusted to thetraditional authority and rational-legal authority. In actual fact,authority construction of Weber is nothing.
Budaya Sebagai Perekat Hubungan Antara Umat Beragama di Suku Tenger
Authors: Huda M Thoriqul , Khasanah Irma Khasanah
Published: July 2019

Indonesia is a country that has diversity in ethnicity, ethnicity, race,language, religion, and culture. However, this diversity is capable ofcausing conflicts both internally and externally. As with many cases thatoccur in Indonesia. Religion itself is a foothold, belief, and life guide, evenas a scapegoat for conflicts in society. But other than the tengger tribelocated in Lumajang Regency, Malang Regency, Pasuruan Regency andProbolinggo Regency, there are three religions that coexist in one villagenamely Islam, Hinduism and Buddhism. In the midst of pluralism,different societies of understanding and belief turned out to be able tohave an attitude of tolerance and mutual respect between each other.Religious diversity is not a problem for the agrosari community tointeract in carrying out daily activities. Regarding tolerance amongreligious people has recently become a very sticky issue amongacademics and the public. Local wisdom and culture are solutions toovercome this problem. Local wisdom in the Tengger tribe community isinseparable from the values of Javanese culture, as well as the culturalheritage of Majapahit which is still developing with mutual respect,tolerance, and respect for ancestral spirits and there are no strikingdifferences in ethnicity other than differences in religious beliefs.Togetherness is manifested in the form of traditional rituals such as theUnan-Unan ceremony, Bari'an (Selamatan). Each religion has its owndemands for tolerance in the Tengger tribe is ingrained, the Tenggertribe community also upholds equality and democracy in community lifeand respects religious leaders and dukun (sepiritual teachers) ratherthan administrative leaders. Because all are brothers, all families, stillpeaceful and harmonious, which is the mandate and ancestral heritage.
KUALITAS TAMAN KOTA SEBAGAI RUANG PUBLIK DI KOTA SURAKARTA BERDASARKAN PERSEPSI DAN PREFERENSI PENGGUNA
Authors: Pratomo Anggit , Soedwiwahjono Soedwiwahjono , Miladan Nur
Published: July 2019

Taman kota adalah salah satu jenis ruang terbuka hijau publik yang memiliki aktivitas kompleks. Taman kota sebagai ruang publik perkotaan dikatakan memenuhi kualitas apabila mencapai kelayakan terhadap kriteria: pelayanan pengguna, tingkat aktivitas, tingkat kebermaknaan dan kemudahan akses. Di Kota Surakarta terdapat beberapa taman kota dengan jumlah pengunjung yang berbeda beda. Persepsi dan preferensi pengguna taman kota merupakan salah satu cara untuk mengetahui kualitas taman kota di Kota Surakarta agar dapat digunakan secara maksimal. Tujuan penelitian ini adalah untuk mengetahui kualitas taman kota sebagai ruang publik di Kota Surakarta berdasarkan persepsi dan preferensi pengguna. Metode yang digunakan dalam penelitian ini adalah skoring dengan pendekatan kuantitatif, sementara jenis penelitian ini adalah eksplanatif. Berdasarkan kriteria taman kota, diperoleh taman kota yang masuk ke dalam sampel penelitian yaitu Taman Kompleks Stadion Manahan dan Taman Balekambang. Sampel dari peneliian ini merupakan pengguna taman. Data diperoleh dengan menggunakan kuisioner yang diisi oleh pengguna taman. Analisis tiap kriteria kualitas taman dilakukan dengan menggunakan tabel distribusi frekuensi untuk mengetahui modus pada kategori jawaban setiap variabel. Di akhir analisis dilakukan skoring untuk mengetahui tingkat kualitas taman kota di Kota Surakarta. Hasil analisis menunjukkan bahwa elemen taman kota dengan kondisi baik meliputi tingkat aktivitas, sementara elemen pelayanan pengguna, kebermaknaan dan kemudahan akses berada pada kondisi sedang, sehingga kualitas taman kota di Surakarta berdasarkan persepsi dan preferensi pengguna yaitu Taman Kompleks Stadion Manahan dan Taman Balekambang berada pada kondisi sedang. Berdasarkan teori, isu, serta hasil analisis terkait taman kota, maka diperoleh hasil bahwa kualitas taman kota di Kota Surakarta dalam kondisi baik.
FAKTOR YANG MEMPENGARUHI KEBERADAAN KAWASAN PERMUKIMAN KUMUH DI SURAKARTA
Authors: Krisandriyana Maresty , Astuti Winny , Fitria Rini Erma
Published: July 2019

Kawasan permukiman kumuh merupakan kawasan yang terabaikan dari pembangunan kota dengan kondisi lingkungan permukiman yang mengalami penurunan kualitas fisik, sosial ekonomi dan sosial budaya dan dihuni oleh orang-orang miskin, penduduk yang padat, serta dengan sarana prasarana yang minim. Di Surakarta terdapat tiga tipologi kawasan permukiman kumuh, yaitu kawasan permukiman kumuh bantaran sungai, kawasan permukiman kumuh padat perkotaan dan kawasan permukiman kumuh sepanjang rel kereta api. Banyak faktor yang dapat mempengaruhi keberadaan kawasan permukiman kumuh. Faktor-faktor tesebut antara lain urbanisasi, sarana prasarana, ekonomi, lahan perkotaan, tata ruang, daya tarik perkotaan, sosial budaya, status kepemilikan bangunan dan lama tinggal penghuni. Penelitian ini dilakukan untuk mengetahui faktor prioritas yang mempengaruhi keberadaan kawasan permukiman kumuh di Surakarta dengan menggunakan analisis prioritas (Analytic Hierarchi Process). Berdasarkan analisis AHP, faktor prioritas yang mempengaruhi keberadaan kawasan permukiman kumuh di Surakarta berbeda tiap tipologinya. Faktor prioritas kawasan permukiman kumuh bantaran sungai adalah faktor lahan perkotaan, faktor tata ruang dan faktor status kepemilikan bangunan. Faktor prioritas yang mempengaruhi keberadaan kawasan permukiman kumuh padat perkotaan yaitu faktor lahan perkotaan, faktor tata ruang dan faktor ekonomi. Sedangkan faktor prioritas yang mempengaruhi keberadaan kawasan permukiman kumuh sepanjang rel kereta api adalah faktor status kepemilikan bangunan, faktor ekonomi dan faktor tata ruang
DEVELOPMENT OF PENCAK SILAT LEARNING MEDIA BASED ON MACROMEDIA FLASH 8
Authors: Ihsan Nurul , Valentino Riko
Published: July 2019

The purpose of this study is to develop an interactive multimedia on Pencak Silat materials using the application Macromedia Flash 8 for grade VIII and to find out the feasibility, practicality and effectiveness of learning media using Macromedia Flash 8.  The development model used in this study is the development model of Borg and Gall. Applications based on the results of the validity test from the material experts obtained a value of 4.33 in the "Valid" category so that the material was declared good to use. From the results of the validity testing of media experts, it was obtained a value of 4.09 with the category "Valid". So that it can be concluded that this learning media is feasible and can be tested. Furthermore, based on the practicality test obtained an average of 4.05 with the category "Practical". The results of the effectiveness test, the results of tcount> ttable are 2.12> 1.73. So that it can be concluded that the interactive multimedia learning of Pencak Silat material grade VIII using the application of Macromedia Flash 8 is practical and effectively used as a learning media for Pencak Silat
Prognostic factors for pulmonary large-cell neuroendocrine carcinoma: a competing-risks analysis
Authors: Huang Qian , Liu Jie , Huang Qiao , Cai Huifang , Zhang Qi , Wang Lina
Published: July 2019

Background

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and highly invasive subtype of lung cancer that accounts for fewer than 3% of cases. The prognostic factors for pulmonary LCNEC are unclear in the literature.

Methods

Patients diagnosed with pulmonary LCNEC between 2004 and 2015 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. The CumIncidence function was used for the univariate analysis. Multivariate analysis was performed using Cox regression analysis, subdistribution hazard function analysis, and cause-specific hazard function analysis.

Results

We finally screened 1246 patients diagnosed with pulmonary LCNEC, among whom 796 died of LCNEC and 141 died from other causes. The univariate analysis showed that sex, primary site, laterality, American Joint Committee on Cancer (AJCC) stage, T stage, N stage, M stage, lymph-node status, surgery, and chemotherapy were significant prognostic factors for pulmonary LCNEC (P<0.05). The multivariate analysis demonstrated that sex, AJCC stage, TNM stage T4, TNM stage N3, lymph-node status, surgery, and chemotherapy were independent risk factors for the prognosis (P<0.05).

Conclusion

We have conducted a competing-risks analysis of patients with pulmonary LCNEC in the SEER database. The results showed that sex, AJCC stage, TNM stage T4, TNM stage N3, lymph-node status, surgery, and chemotherapy are independent prognostic factors for pulmonary LCNEC patients. The reported data represent reference information that can be used for accurate assessments of the prognosis of pulmonary LCNEC patients.
Group B Streptococcus detection in pregnant women: comparison of real-time PCR assay, culture, and the Xpert GBS rapid test
Authors: Vieira Laura , Perez Amanda Vilaverde , Machado Monique M , Kayser Michele L , Vettori Daniela V , Alegretti Ana Paula , Ferreira Charles Francisco , Vettorazzi Janete , Valério Edimárlei G
Published: July 2019

Background

Group B Streptococcus (GBS) is one of the most important causative agents of neonatal sepsis. As administration of prophylactic antibiotics during labor can prevent GBS infection, routine screening for this bacterium in prenatal care before the onset of labor is recommended. However, many women present in labor without having undergone such testing during antenatal care, and the turnaround time of detection methods is insufficient for results to be obtained before delivery.

Methods

Vaginal and anorectal specimens were collected from 270 pregnant women. Each sample was tested by Xpert GBS, PCR, and culture for GBS detection.

Results

The overall prevalence of maternal GBS colonization was 30.7% according to Xpert GBS, 51.1% according to PCR, and 14.3% according to cultures. Considering the PCR method as the reference, the Xpert GBS had a sensitivity of 53% and specificity of 93%. Positive Xpert GBS results were associated with marital status (married or cohabitating) and with prematurity as a cause of neonatal hospitalization. Positive cultures were associated with ischemic–hypoxic encephalopathy requiring therapeutic hypothermia.

Conclusions

Combined enrichment/PCR and the Xpert GBS rapid test found a high prevalence of GBS colonization. The Xpert GBS technique gives faster results and could be useful for evaluating mothers who present without antenatal GBS screening results and are at risk of preterm labor, thus allowing institution of prophylactic antibiotic therapy. Trial Registration: The study was approved by the institutional Research Ethics Committee (CAAE: 59688316.0.0000.5327)
Comparison of efﬁcacy and safety of oxycodone versus fentanyl for intravenous patient-controlled analgesia in postoperative pain management: a systematic review and meta-analysis
Authors: Chen Peng , Chen Fuchao , Lei Jiexin , benhong zhou
Published: July 2019

Backgroud

Patient-controlled analgesia(PCA) with intravenous an opioid has been suggested as a effective method of postoperative pain relief. There are several randomized controlled trials (RCTs) of comparison of oxycodone and fentanyl for IV-PCA in surgical patients. The purpose of this study was to performed a meta-analysis to compare the effect of intravenous oxycodone and fentanyl on post-operative pain in sugical patients from collected current data.

Methods

The RCTs of oxycodone versus fentanyl for IV-PCA were gathered from PubMed, Embase, Cochrane library, CNKI and VIP data. After data extraction and quality assessment of the included RCTs, the RevMan 5.3 software was applied for meta-analysis of numerical rating scale (NRS) scores, accumulated IV-PCA consumption of oxycodone and fentanyl, patient satisfaction, postoperative nausea and vomiting (PONV), and other adverse events (AEs).

Results

Results reported from eight RCTs involving 600 patients are included in the meta-analysis. The NRS score at rest and upon movement of group oxycodone was signiﬁcantly lower than that of group fentanyl (WMD= -3.85, 95% CI -4.93~-2.76, P<0.00001; WMD= -4.31, 95% CI -5.79~-2.84, P<0.00001); however, the incidence of PONV and dizziness was signiﬁcantly higher in group oxycodone than in group fentanyl (OR = 2.41, 95% CI 1.60~3.63, P < 0.0001; OR=3.69, 95% CI 2.17~6.26, P<0.00001). Accumulated IV-PCA consumption in group oxycodone was less than in group fentanyl overall the 48 hours postoperatively (WMD= -12.11, 95% CI -18.42~-5.80, P = 0.0002). There was no significant difference in patient satisfaction between oxycodone and fentanyl (OR=0.73, 95% CI 0.11~5.04, P= 0.75).

Conclusion

According to the evidence, this meta-analysis suggest that oxycodone IV-PCA is superior to fentanyl in postoperative pain relief, whereas the higher incidence of PONV and dizziness was accompanied with oxycodone. Further large-scale and well-designed studies are needed to summarize and analyse the data to draw a more convincing conclusion.
Hygiene protocols for the treatment of denture-related stomatitis: local and systemic parameters analysis
Authors: Ribeiro Adriana Barbosa , de Araújo Camila Borba , Bueno Frank Lucarini , Silva Luiz Eduardo , Fazan-Junior Rubens , Salgado Helio Cesar , Ribeiro Aline Barbosa , Fortes Caroline Vieira , Oliveira Viviane de Cássia , Paranhos Helena de Oliveira , Silva-Lovato Cláudia Helena
Published: July 2019

Background
The Denture-related stomatitis (DS) is a chronic multifactorial inflammation, strongly related to the presence of the biofilm. This oral condition has recently been correlated with deleterious cardiovascular alterations. The potential effect of hygiene protocols in the control of DS and Randomized clinical trials that address this oral condition with cardiovascular complications are necessary for clinical decision-making.
Material/design
A clinical trial, randomized, double-blind, of parallel groups, will be conducted in Brazil and the sample will be composed of 100 total edentulous individuals bi-maxillary, users of at least maxillary complete dentures, diagnosed with DS that will be allocated according to the different hygiene protocols: (1) brushing of the palate and immersion of the prosthesis in 0.25% sodium hypochlorite solution (positive control); (2) brushing of the palate and immersion of the prosthesis in 0.15% Triclosan solution; (3) brushing of the palate and immersion of the prostheses in lactose monohydrate; (4) brushing the palate with citric acid and immersing the prosthesis in lactose monohydrate. The response variables will be: heart rate variability and alteration of blood pressure (systemic level), remission of Denture-related Stomatitis, removal of biofilm, reduction of microbial load (CFU), mouth and prosthesis odor level, expression of MUC1, proinflammatory cytokines, C-reactive protein level - CRP, viscosity, pH and salivary flow (locally). Measurements will be performed in the Baseline and ten days after the interventions. The results obtained will be submitted to the pertinent statistical analysis with a level of significance of 0.05.
Discussion
This study will provide a guideline of clinical practice regarding the use of hygiene protocols in the treatment of oral diseases mediated by biofilm. Also, it may provide evidence of correlation of oral manifestation with cardiac risk.
Management of initial colonisations with Burkholderia species in France, a retrospective analysis in five Cystic Fibrosis Centres
Authors: Gruzelle Vianney , Guet-Revillet Hélène , Segonds Christine , Bui Stéphanie , Macey Julie , Chiron Raphael , Michelet Marine , Murris-Espin Marlène , Mittaine Marie
Published: July 2019

Whereas Burkholderia infections are recognized to impair prognosis in cystic fibrosis (CF) patients, there is no recommendation to date for early eradication therapy. The aim of our study was to analyse the current management of initial colonisations with Burkholderia cepacia complex (BCC) or B. gladioli in French CF Centres and its impact on bacterial clearance and clinical outcome. We performed a retrospective review of the primary colonisations (PC) observed between 2010 and 2018 in five CF Centres. Treatment regimens, microbiological and clinical data were collected. Seventeen patients (14 with BCC, and 3 with B. gladioli) were included. Eradication therapy, using heterogeneous combinations of intravenous, oral or nebulised antibiotics, was attempted in 11 patients. Six out of the 11 treated patients, and 4 out of the 6 untreated patients cleared the bacterium. Though not statistically significant, higher FEV1 and FVC at PC and consistency of treatment with in vitro antibiotic susceptibility tended to be associated with eradication. Thus, the management of PC was shown to be heterogeneous, and the statistic power of our study insufficient. Large prospective studies are needed to define who to treat, when, and how. Pending these studies, we propose, due to possible spontaneous clearance, to check the presence of Burkholderia one month after PC before starting antibiotics, at least in the milder cases, and to evaluate a combination of IV beta-lactam + oral or IV fluoroquinolone + inhaled aminoglycoside.
Spoligotyping and Drug Sensitivity of Mycobacterium tuberculosis isolated from Pulmonary Tuberculosis Patients in the Arsi Zone of South Eastern Ethiopia
Authors: Nega Belete Haile , Tafess Ketema , Zewude Aboma , Yenew Bazezew , SIU Gilman , Ameni Gobena
Published: July 2019

Background

Tuberculosis (TB) is one of the leading disease causing morbidity and mortality in different zones of Ethiopia including the Arsi Zone. However, little or no scientific information is available on the strains of Mycobacterium tuberculosis and their drug sensitivity profiles in this Zone. This study was conducted to identify the strains of M. tuberculosis and evaluate their drug sensitivity profiles.

Methodology

A total of 111 clinical isolates of M. tuberculosis from patients with pulmonary TB in the Arsi Zone were used for this study. The region of difference 9 (RD 9)-based polymerase chain reaction (PCR)and spoligotyping methods were used for speciation and strain identification of Mycobacterium tuberculosis respectively.The spoligotyping patterns were compared with the international SpolDB4 (SITVIT) and Run TB-Lineage used for the identification of lineages. The phenotypic drug susceptibility patterns were confirmed by BD BactecMGIT 960 SIRE test and GenoType MTBDRplus line probe assays were used for the detection the drug resistance-conferring mutations of the isolates.

Result

The spoligotype patterns of 83% (92/111) of the isolates were interpretable and 56 different patterns were identified. Twenty-two of these patterns were shared types while the remaining 34 were orphans. The predominant shared types were spoligotype international type (SIT) 149 and SIT53, each consisting of 12 and 11 isolates, respectively. The lineages identified were Euro-American, East-African-Indian, Mycobacterium-africanum, and Indo-Oceanic in descending order. Phenotypically, 17.2% of the 64 tested isolates were resistant to any of the four first-line drugs while 3.1% of them were multi-drug resistant (MDR). Higher (6.2%) monoresistance was observed to Streptomycin followed by Isoniazid (3.1%) while no resistance was observed either to Rifampicin or to Ethambutol. Genotypically, five (5.4%) isolates were resistant to Isoniazid and mutated at codon S315T1 of katG. On the other hand, only 1.1% of the isolates was resistant to Rifampicin and mutated at codon S531L of rpoB gene.

Conclusion

The proportion of orphan strains isolated in this study was high, which could suggest the presence of new strains in the Zone. Moreover, the study showed relatively high percentage of mono-resistance to any four first-line drugs warranting for the need to strengthen the control efforts.
Quick selenium accumulation in selenium-rich rice and its physiological changes in selenium environment
Authors: Liang Yuanke , Farooq Muhammad Umer , Su Yang , Zeng Rui , Zhang Yujie , Ei Hla Hla , Tang Zhichen , Zheng Tengda , Ye Xiaoying , Jia Xiaomei , Zhu Jianqing
Published: July 2019

Background: The element selenium (Se) deficiency is recognized as a global health problem. Improving Se accumulation in rice grain is an important issue for human health. But Se is both essential and toxic for plants, with a narrow margin between deficiency and toxicity and the mechanism for Se accumulation and tolerance in selenium-rich rice plants remains unknown.
Results: In this study, we investigated the phenotypical, physiological and biochemical changes of selenium-rich rice exposed to different stages of Se concentrations. Results showed that selenium-rich rice can accumulate more Se from the root in low selenate environment comparing with selenium-free normal rice. Besides, excessive selenate caused phytotoxic effects on selenium-rich rice plants by inducing chlorosis, dwarfness, reduced antioxidant contents, and exacerbating oxidative stress. Furthermore, both phosphate transporter OsPT2 and sulfate transporters OsSultr1;2 can contribute to selenite uptake in rice.
Conclusions: Based on the results, selenium-rich red rice is more sensitive to Se and the best Se concentration for selenium-rich rice is 20μM in the root environment. Such findings can be used to direct and evaluate the toxic effects of Se contamination on selenium-rich rice in the field. To draw a sound conclusion, long-term field trials are still required, including risks and benefits analysis for various management strategies.
Implementation of multithreaded calculations in educational web applications
Authors: Molchanov Viktor
Published: July 2019

The complication of the logic of educational web applications raises the issue of the effectiveness of the organization of their implementation. At the same time, efficiency, including pedagogical one, is connected among other factors with the technology of implementation of programs. When using as the main browser program, it is necessary to take into account its features, in particular, one-flow mode of execution of programs (scripts). Implementation of more complex algorithms in web applications delays the response of the application interface to user actions. This creates a discomfort for the user and, as a result, reduces the effectiveness of his work. Expanding the range of devices from which users access the Internet leads to the fact that mobile devices are more and more often used for learning as well. Therefore, another side of the problem is the impact on the quality of connection to the server. It is necessary to ensure the work of the program in case of interruptions in connection or reduce their impact. A solution to the problem may be the implementation of part of the calculations in the background. The article deals with the use of calculations in the background streams of the browser and caching control for educational web applications. Various ways of creating such streams and the peculiarities of their use are analyzed.
EDUCAÃ‡AO E DESIGUALDADES REGIONAIS: OS IMPACTOS DO FUNDEB NO BRASIL
Authors: Frinhani Paulo Eduardo
Published: July 2019

O objetivo do estudo Ã© mostrar os impactos do Fundeb no financiamento da educaÃ§Ã£o bÃ¡sica pÃºblica brasileira no perÃ­odo de 2005 a 2009, tendo por comparaÃ§Ã£o o crescimento do Ideb nas regiÃµes brasileiras. Para avaliar os impactos do Fundeb e os resultados alcanÃ§ados, esta pesquisa analisa - novo padrÃ£o de financiamento da educaÃ§Ã£o bÃ¡sica introduzido pelo fundo, buscando verificar se o fundo estabelece uma polÃ­tica nacional de correÃ§Ã£o das desigualdades regionais e analisar a trajetÃ³ria dos recursos disponÃ­veis do valor aluno/ano aplicado nas regiÃµes brasileiras podendo concluir seÂ  Fundeb representa um importante avanÃ§o para o equilÃ­brio federativo no financiamento da educaÃ§Ã£o bÃ¡sica, ampliando a discussÃ£o entre a politica social, educacional e econÃ³mica no Brasil atravÃ©s da avaliaÃ§Ã£o da introduÃ§Ã£o do Fundeb
QUESTAO HABITACIONAL EM MANHUAÃ‡U E A GARANTIA DE DIREITOS DE CIDADANIA: UMA EQUAÃ‡ÃƒO POSSÃVEL?
Authors: Silva Luciana Bosco e , Silva RutelÃ©ia CÃ¢ndida de Souza , Abreu Roberto Vicente Silva de
Published: July 2019

Ao longo da histÃ³ria, as mazelas e precariedades habitacionais sempre acometeram milhÃµes de pessoas no Brasil. Essa realidade tambÃ©m se materializa em ManhuaÃ§u-MG, cidade marcada por uma heranÃ§a coronelista, num contexto de resignaÃ§Ã£o e "naturalizaÃ§Ã£o" da pobreza, sobretudo, a partir da desorganizaÃ§Ã£o polÃ­tica dos segmentos mais vulnerabilizados. As discussÃµes propostas neste artigo tÃªm como objetivo justamente traÃ§ar algumas consideraÃ§Ãµes em torno da qualidade das habitaÃ§Ãµes e as localidades de maior incidÃªncia de carÃªncias habitacionais no municÃ­pio. Procura estabelecer conexÃµes entre a crise habitacional eÂ  processo de crescimento e urbanizaÃ§Ã£o da cidade, sobretudo, num contexto em que as aÃ§Ãµes e iniciativas adotadas tÃªm assumido, em geral, um carÃ¡ter meramente pontual ou sem bases sustentÃ¡veis necessÃ¡rias Ã  resoluÃ§Ã£o deste problema. O que se observa Ã© que tal situaÃ§Ã£o requer a adoÃ§Ã£o de polÃ­ticas pÃºblicas viabilizadoras de direitos sociais e de cidadania, promotoras de desenvolvimento social, econÃ´mico e ambiental da regiÃ£o.
MULHERES CHEFES DE FAMILIA NO BRASIL COLÃ”NIA
Authors: Souza Sara Bruna Lopes de
Published: July 2019

A presente pesquisa se propÃµe a analisar a estrutura da famÃ­lia brasileira no Brasil Colonial, sendo a chefia feminina de domicÃ­lios o destaque deste. Para desenvolver este trabalho valemo-nos de dissertaÃ§Ãµes e outros estudos que abordam tal assunto. Assim, buscaremos entender qual foi o real valor da famÃ­lia patriarcal na sociedade colonial, quem eram as mulheres que chefiavam lares, destacando o que propiciou a formaÃ§Ã£o de tais fogos e como estas mulheres viviam, quais eram suas estratÃ©gias de sobrevivÃªncia. Sabe-se que as atividades exercidas por essas mulheres variaram em diferentes funÃ§Ãµes, e foi por meio delas que sustentavam seus lares. Desta forma, ao analisar a diversidade quanto Ã  organizaÃ§Ã£o familiar, destacaremos como a chefia feminina de domicÃ­lios foi um fenÃ´meno comum na famÃ­lia brasileira.
AS PECULIARIDADES DA QUESTÃƒO AGRÃRIA NA REGIÃƒO DA VERTENTE OCIDENTAL DO CAPARAÃ“
Authors: Portes Adriano Santos , Borges Ana Paula CÃ¢ndido , Cardoso Daniela Damaris , Moraes Leslie de , Oliveira SÃ¡squia Fernanda de
Published: July 2019

Dissertar sobre a categoria trabalho na contemporaneidade correlacionando-a com a questÃ£o agrÃ¡ria Ã© um desafio para os estudantes de graduaÃ§Ã£o. Neste artigo, discentesdo curso de ServiÃ§o Social da Faculdade de CiÃªncias Gerenciais de ManhuaÃ§u (FACIG) buscam compreender as particularidades do processo de trabalho da vertente Ocidental do CaparaÃ³, com vistas a identificar os desafios colocados para o trabalho dos assistentes sociais na regiÃ£o. Este assunto estimula a capacidade crÃ­tica ao provocar a realizaÃ§Ã£o de anÃ¡lises referentes ao modo de produÃ§Ã£o capitalista atual e suas implicaÃ§Ãµes na produÃ§Ã£o agrÃ­cola e no trabalho rural.
A FAMÃLIA CONTEMPORÃ‚NEA NEOPENTECOSTAL E O LUGAR DO AMOR E DA RELIGIOSIDADE NA RELAÃ‡ÃƒO CONJUGAL
Authors: Silva Daniel Rodrigues
Published: July 2019

O presente estudo procura compreender a relaÃ§Ã£o existente entre sexualidade e religiosidade na relaÃ§Ã£o conjugal de mulheres evangÃ©licas de uma igreja com denominaÃ§Ã£o neopentecostalda zona rural do MunicÃ­pio de Lajinha/MG. Observam-se as prÃ¡ticas adotadas pelo grupo atravÃ©s dos comportamentos e normas sociais adotadas a sobre a sexualidade das mulheres rurais e a possÃ­vel influÃªncia da religiÃ£o na conduta pessoal e Ã­ntima de suas adeptas. Trata-se de um estudo de caso realizado com mulheres de idades compreendidas entre 18 e 60 anos. Neste universo estÃ£o envolvidas 211 mulheres que frequentam a igreja, incluindo batizadas, nÃ£o batizadas e as frequentadoras eventuais. Para a pesquisa aplicou-se a metodologia qualitativa, onde foram feitas observaÃ§Ãµes participantes e entrevistas com um roteiro semiestruturado. As entrevistadas trazem consigo evidÃªncias de conflitos e ambiguidades em suas trajetÃ³rias sexuais, onde pode-se observar a influÃªncia de mitos e crenÃ§as provenientes de uma rÃ­gida educaÃ§Ã£o familiar influenciando fortemente em seu modo de vida atual. Observou-se que a religiÃ£o atua efetivamente no casamento e na vida conjugal das mulheres. As mulheres tÃªm orientaÃ§Ã£o e auxÃ­lio, e recorrem Ã  igreja quando se deparam com algum problema familiar importante de difÃ­cil resoluÃ§Ã£o para elas, obtendo na igreja o alicerce que lhes dÃ¡ forÃ§a para enfrentar os dissabores do casamento, como por exemplo, o adultÃ©rio. Os conceitos de amor e sexo sÃ£o reelaborados de acordo com a orientaÃ§Ãµes religiosas de forma a ordenar uma identidade que busque traduzir uma personalidade equilibrada e Ã­ntegra de acordo com o que preconiza a denominaÃ§Ã£o em estudo.Â
Hydro-chemical assessment and GIS-mapping of groundwater quality parameters in semi-arid regions
Authors: Honarbakhsh Afshin , Azma Aliasghar , Nikseresht Fahime , Mousazadeh Milad , Eftekhari Mobin , Ostovari Yaser
Published: July 2019

Groundwater quality assessment is vital to protect this resource. Therefore, the aims of this study were to evaluate the hydro-chemical quality of the Marvdasht aquifer located in the semi-arid region of Iran and to map the groundwater quality parameters. For this purpose, a mean data of 11 groundwater quality parameters collected from 49 wells (2010–2015) were used. Pie, Schoeller and Piper diagrams were used to determine the dominant ions and type of water. Ion ratios and Gibbs diagrams were used to illustrate the chemistry and processes in the groundwater. Spatial distribution of quality parameters were mapped using ArcGIS. Results showed that the water type is Na-Cl and Cl− with abundance orders of CL− > SO42− > HCO3− and Na+ with abundance orders of Na+ > Mg2 + >Ca2+ > K+ are dominant anion and cation, respectively. Gibbs diagrams revealed that geological formations control the groundwater chemistry in 66% of the groundwater samples. Based on the Wilcox diagram, only 24% of the samples fell into the C4–S4 class with high salinity and alkalinity hazard. The maps showed that generally groundwater in the north of the study site has better quality than that the south of the study site, where the existence of dolomite and chalky formations leads to decreasing water quality.
Selective removal of silicic acid by a gallic-acid modified resin
Authors: Bai Shuqin , Han Jue , Du Cong , Ding Wei
Published: July 2019

To remove silicic acid from aqueous solutions, a novel gallic acid-type resin (GA-type resin) was prepared by a grafting method. The effects of the adsorption capacity, pH and presence of NaCl, NaNO3, Na2SO4, and NaCO3 salts on the silicic acid removal were studied. The GA-type resin adsorbs monosilicic acid, silicate ions, and polymeric silicic acid. The adsorption capacity of 4.64–4.94 mg/g was achieved in a short adsorption time (Qm of 8.99 mg/g) and is 30–40 times larger than that of the OH-type resin. The silicic acid removal efficiency was almost unaffected by the pH and common anions when the common anion and silicic acid contents were similar, proving the GA-type resin exhibits an excellent performance for selective adsorption of silicic acid. The Temkin isotherm model can well describe the adsorption process, which is chemical adsorption, and indicates that the adsorption heat decreases with the increasing adsorption amount. The adsorption mechanism of silicic acid on the GA-type resin involves dehydration condensation reactions of the hydroxyl groups in silicic acid and gallic acid. The GA-type resin can be efficiently regenerated and reused after treatment with an HCl solution.
Synthetic Approaches Towards Antihypercholesterolemic Drug Simvastatin
Authors: Fattah Tanzeela A. , Saeed Aamer , Shehzadi Syeda A.
Published: July 2019

Cardiovascular diseases are among the most threatening problems being faced by twenty-first
century humans. The core cause of these diseases is high cholesterol level. Simvastatin (1: Synvinolin) is a
well-known cholesterol-lowering drug marketed under the trade name Zocor®, which significantly reduces the
risk of cardiovascular diseases related to hypercholesterolemia and is effective in lowering the total plasma
cholesterol, low-density and very low-density lipoprotein cholesterol. It also enhances the high-density
lipoprotein cholesterol. This review article aims to provide an overview of several chemical and biological
methods utilized for the production of simvastatin in high yields and purity. Many robust and scalable methods
have been described using lovastatin (2: Mevinolin) as a starting material, produced by the fungal strain of
Aspergelius terreus. Enzymatic synthesis of simvastatin is also highlighted in this review. In addition, detailed
experimental conditions, as well as the compatibility for industrial-scale preparations of simvastatin are also
discussed.
Relationship Between Postpartum Health Care With Contraceptive After Childbirth In Indonesia
Authors: Pratiwi Arantika Meidya
Published: July 2019

Result of SDKI 2012 show that MMR in Indonesia is 359 deaths per 100,000 live births. This result show that Indonesia still far from the target SDGs (Suitable Development Goals), who reducing the Maternal Mortality Rate (MMR) to 70 per 100,000 live birth. One of the breakthrough programs of the Ministry of Health in an effort to accelerate the reduction in maternal mortality is to increase contraceptive after childbirth. The coverage of contraceptive after childbirth in Indonesia is still far from what is expected, from the 2013 Riskesdas data the coverage of contraceptive after childbirth in Indonesia was only 59.6%. Papua became a province with the lowest coverage of only 26%. The purpose of this study was to determine the relationship between postpartum health care and contraceptive after childbirth in Indonesia. This study using  secondary data from "2013 Basic Health Research" conducted by the Health Research and Development Institute. The 2013 Riskesdas survey uses a cross sectional design. The results of the Chi-Square test showed that there were 0,0001, which meant that there was a relationship between postpartum health care and contraceptive after childbirth in Indonesia. While the results of the analysis of OR values were 1.595, which means that mothers who received health care during the postpartum were 1.6 times more likely to use contraceptive after childbirth.
Breast Cancer Detection and Diagnosis Using Mammographic Data: Systematic Review
Authors: Gardezi Syed Jamal Safdar , Elazab Ahmed , Lei Baiying , Wang Tianfu
Published: July 2019

Background

Machine learning (ML) has become a vital part of medical imaging research. ML methods have evolved over the years from manual seeded inputs to automatic initializations. The advancements in the field of ML have led to more intelligent and self-reliant computer-aided diagnosis (CAD) systems, as the learning ability of ML methods has been constantly improving. More and more automated methods are emerging with deep feature learning and representations. Recent advancements of ML with deeper and extensive representation approaches, commonly known as deep learning (DL) approaches, have made a very significant impact on improving the diagnostics capabilities of the CAD systems.

Objective

This review aimed to survey both traditional ML and DL literature with particular application for breast cancer diagnosis. The review also provided a brief insight into some well-known DL networks.

Methods

In this paper, we present an overview of ML and DL techniques with particular application for breast cancer. Specifically, we search the PubMed, Google Scholar, MEDLINE, ScienceDirect, Springer, and Web of Science databases and retrieve the studies in DL for the past 5 years that have used multiview mammogram datasets.

Results

The analysis of traditional ML reveals the limited usage of the methods, whereas the DL methods have great potential for implementation in clinical analysis and improve the diagnostic capability of existing CAD systems.

Conclusions

From the literature, it can be found that heterogeneous breast densities make masses more challenging to detect and classify compared with calcifications. The traditional ML methods present confined approaches limited to either particular density type or datasets. Although the DL methods show promising improvements in breast cancer diagnosis, there are still issues of data scarcity and computational cost, which have been overcome to a significant extent by applying data augmentation and improved computational power of DL algorithms.