bluuebunny/crossref_metadata_2025 huggingface dataset:
Adverse Drug Reactions in Corona Virus Disease Patients Admitted to Intensive
Care Unit: An Observational Study
Authors: Chopra Deepti , Nazir Nazia , Bhandari Bharti , Sidhu Jaspreet Kaur
Published: May 2022

Background:

Occurrence of adverse drug reactions (ADRs) in COVID-19 patients has
not been extensively studied.

Aim:

The present study was conducted to analyze the pattern of suspected ADRs in the COVID-19
Intensive Care Unit (ICU).

Methods:

In this cross-sectional study, all the individual case study reports of patients admitted to
the COVID ICU (August-October 2020) were analyzed for type of ADRs, system involved, suspected
drug, onset time, time to revert and management.

Results:

Thirty six patients (out of 395 patients admitted) experienced 44 ADRs. Dermatological
manifestations were the most frequent ADRs. Remdesivir was the most common drug associated
with ADRs. The female gender, polypharmacy (>5 drugs) and presence of comorbidities were the
independent risk factors for the occurrence of ADRs.

Conclusion:

Use of many of these drugs in COVID-19 is experimental and the literature does not
guarantee their safety and efficacy. During these times of uncertainty, the results from the present
study reinforce the importance of monitoring patients.
Perception and Self-Medication Practices Among the General Population
During the Ongoing COVID-19 Pandemic in Mangalore, India
Authors: Joseph Nitin , Colaco Sumith Marian , Fernandes Ronel Valentine , Krishna Sarvesh G. , Veetil Sourav I.
Published: May 2022

Background:

The practice of self-medication appears to be much more rampant during the-
COVID-19 pandemic. Hence, awareness about its consequences is essential among the general population
during the current circumstances.

Objectives:

To study the prevalence of and perception towards self-medication, as well as its determinants
among the general population of Mangalore.

Methods:

This cross-sectional study was done during the second wave of the COVID-19 pandemic in
August 2021. Data were collected using a Microsoft form disseminated among residents of Mangalore
through WhatsApp and email.

Results:

The mean age of the 225 participants in this study was 34.5±15.2 years. Self-medication practice
was indulged by 77(34.2%) out of the total participants. The most common symptom for which
self-medication was practiced was for common cold [54(70.1%)], and the most commonly used drug was
paracetamol [67(87%)]. 167(74.2%) participants felt that self-medication practices were harmful, but the rest
58(25.8%) felt that it was not a harmful practice. 116 (51.6%) participants felt that the advertisements in
mass media and social media promoted self-medication practices among people. Out of the 69(30.7%) participants
who felt that self-medication practice was acceptable during the current circumstances, the majority
[66(95.6%)] felt that it was better to avoid visiting any doctor or health care facility presently to avoid acquiring
COVID-19. In the multivariable analysis, participants with a history of self-medication among their family
members, relatives, or friends were more likely to indulge in self-medication (p<0.001). Perceptions that
self-medication practices were harmful were more among females (p=0.0397).

Conclusion:

More than one-third of the participants indulged in self-medication practice. More than
one-fourth of the participants felt that self-medication practices were not harmful. About one-third felt
it was acceptable, and most of them felt so to avoid the risk of contracting the Coronavirus infection.
Awareness of its hazards, particularly among males and those with a family history of selfmedications,
is required at Mangalore.
Developmental Toxicity Assessment of Drymaria Cordata (Linn.) Willd
using Zebrafish Embryo
Authors: Patra Susmita , Bala Asis , Sharma Nanaocha , Haldar Pallab Kanti
Published: May 2022

Introduction:

Drymaria cordata (Linn.) Willd is a creeping herb belonging to the Caryophyllaceae
family, widely used as a traditional medicine in Africa and North-east India for various
ailments. Many therapeutic applications of D. cordata have been reported in various scientific
studies, but the teratogenicity study of this herb has not been documented till now.

Methods:

The present study aimed to assess the developmental toxic effect and median lethal concentration
(LC50) of methanol extract of Drymaria cordata leaf (DCME) using zebrafish embryos.
After spawning of male and female zebrafish, healthy zebrafish embryos were selected by microscopic
screening and transferred into 96-well plate for the study. Embryos were exposed to DCME
at concentrations ranging from 50-400 μg/ml in 2% DMSO from 24 hpf to 72 hpf.

Results:

Developmental and morphological abnormalities were microscopically evaluated. Fifty
percent lethal concentration (LC50) of DCME was determined by observation from 24 hpf to 72
hpf. The concentration-dependent toxic effects of DCME on developing embryos of zebrafish were
found in the study in a time-dependent manner.

Conclusion:

At 72 hpf, the median lethal concentration (LC50) of DCME was found with visible developmental
defects, such as heartbeat rate, less pigmentation, oedema, spinal curvature, immature yolk sac
as well as reduced hatching rate and a slow growth. The median lethal dose was found to be 448 μg/ml
at 72 hpf for zebra fish embryos, meriting further studies on toxicological profiling of the plants.
Awareness and Attitude among Physicians Regarding Bisphosphonaterelated
Osteonecrosis of the Jaw (BRONJ): A Cross-sectional Study
Authors: Priyadarshini Vidya , Ramachandra Srinivas Sulugodu , Ganganna Aruna
Published: May 2022

Background:

An invasive dental procedure is considered one of the risk factors for osteonecrosis
of the jaw, especially among patients on bisphosphonates. This study aimed to determine
the awareness and perceptions of medical practitioners regarding bisphosphonate-related osteonecrosis
of the jaw (BRONJ), and their attitude towards dental referrals of such patients.

Methodology:

This cross-sectional questionnaire-based study was conducted among medical practitioners
in and around Mysore city, Karnataka, India, who commonly prescribe bisphosphonates.
The sample included orthopaedic doctors, physicians, endocrinologists, and oncologists, divided
based on the duration of practice and speciality. Data on the type of practice, awareness of BRONJ,
referral to a dentist before/during therapy, and patient education about adverse effects, were collected
and analyzed. A p-value ≤0.05 was considered statistically significant.

Results:

Among 58 practitioners, 84.5% (49) were aware of the association between bisphosphonates
and BRONJ, while 56.9% (33/58) believed dental procedure to be a risk factor, and 55.2%
(32/58) did not recommend screening of the oral cavity by a dentist before initiation of bisphosphonate
therapy. A majority (65.5%) of them educated their patients about adverse effects. Mean
knowledge scores varied with specialization (post-graduation vs. super specialization = 1.43 vs. 2;
p = 0.01) but not with the duration of practice (<= 10 years vs. >10 years= 1.57 vs. 1.4; p= 0.24).

Conclusion:

The practitioners in our study were oblivious to dental procedures' role in the osteonecrosis
of the jaw, highlighting the need for continuing education programs regarding BRONJ
for medical and dental professionals. Clinicians updated regarding evidence-based practices and
working cooperatively in teams may reduce the incidence of medication-related osteonecrosis of
the jaw.
Impact of ‘Never Use’ Abbreviations (Error-Prone Abbreviations-EPA’s)
List on the Incidence of EPAs in Inpatient Medical Prescriptions in Apex
Tertiary Care Public Hospital in India
Authors: Thachaparambil Arif , Kausar Mohammad , R Mahesh , DK Sharma
Published: May 2022

Aim:

The aim of the study was to assess the impact of never-use list and standardized abbreviations on error prone abbreviations

Background:

Abbreviations are commonly used in medical records to save time and space but use in prescriptions, which can lead to communication failures and preventable harm. Prescriptions need to be clear for correct interpretation. Hospitals should implement uniform use of approved abbreviations, such as an approved list or never-use list of abbreviations and symbols. In the hospital under study, there was no system of avoiding error prone abbreviations while prescribing any medication. Hence, an interventional study was performed to quantify and reduce the incidence of error prone abbreviations.

Objectives:

The main objectives were to determine the incidence of error prone abbreviations, development and implementation of ‘Never-use’ list and standardized abbreviations and finally determine its effectiveness in reducing the error prone abbreviations in the prescriptions.

Methods:

The study design was pre-post interventional / quasi-experimental design. The settings were inpatient wards of broad specialties of a tertiary care hospital. ‘Never-use’ list and standardized abbreviations were developed by review of relevant literature, existing lists by Institute for Safe Medication Practices and Australian Commission on Safety and Quality in Health Care compared against findings of pilot study of prescriptions for error prone abbreviations and experts’ input. Poster copies of the lists were affixed in inpatient wards, doctors were educated and poster pamphlets were distributed. Pre intervention data was collected by a retrospective closed in-patient medical record review. Post interventional incidence of error prone abbreviations was determined and the effectiveness of the same was assessed by using statistical analysis.

Results:

Incidence of error abbreviations in inpatient prescription was 47.5% and ‘Never Use’ list of abbreviation led to a statistically significant reduction of error-prone abbreviation by 8.2% from 47.5% to 43.6% (P\0.006).

Conclusion:

‘Never Use’ lists are effective in reducing incidence of common error-prone abbreviations and discipline wise variation is observed.
Effect of Umbilical Cord Mesenchymal Stem Cell Transplantation Under LIFPUS Pretreatment on Thyroid Function in EAT Rats
Authors: Ren Ziyu , Fang Ronghua , Deng Wenzhen , Long Jiangchuan , Liu Dongfang
Published: May 2022

Background:

A growing number of studies have demonstrated that mesenchymal stem cells (MSCs) can effectively regulate the progression of multiple autoimmune diseases and can respond positively to mechanical stimulation by ultrasound in an in vitro setting to improve transplantation efficacy.

Objective:

The aim of this study was to activate hUC-MSCs by pretreatment with low-intensity focused pulsed ultrasound (LIFPUS) in an in vitro environment and transplant them into a rat model of EAT via tail vein. To investigate the efficacy and potential mechanism of action of hUC-MSCs in the treatment of EAT.

Methods:

In this study, 40 female lewis rats were divided into control, EAT, hUC-MSCs treatment and LIFPUS pretreatment transplantation group. EAT models were established by subcutaneous multi-point injection of PTG+Freund's adjuvant, and the primary hUC-MSCs were treated with different gradients of LIFPUS irradiation or sham irradiation in an in vitro environment and screened by Western Blot (WB), flow cytology cycle analysis, and cellular immunofluorescence to find the optimal treatment parameters for LIFPUS to promote cell proliferation. After tail vein injection of different pretreatment groups of hUC-MSCs, Homing sites of hUC-MSCs in vivo, circulating autoantibody expression levels and local thyroid histopathological changes were assessed by enzyme-linked immunosorbent assay (ELISA), spleen index, tissue hematoxylin-eosin (HE) staining and immunohistochemistry. The expression levels of apoptotic proteins Bcl-2, Bax and endoplasmic reticulum stress-related proteins Chop and EIF2α in thyroid tissue were also examined by WB.

Results:

LIFPUS can effectively stimulate hUC-MSCs in vitro to achieve the most optimal proliferative and secretory activity. In the EAT model, hUC-MSCs can effectively reduce thyroid cell apoptosis, improve thyroid function and reduce excessive accumulation of autoimmune antibodies in the body. in comparison, the LIFPUS pretreatment group showed a more favorable treatment outcome. Further experiments demonstrated that hUC-MSCs transplantation may effectively inhibit the apoptotic state of thyroid follicles and follicular epithelial cells by down-regulating the unfolded protein reaction (UPR) of the PERK pathway, thus providing a therapeutic effect for AIT.

Conclusion:

hUC-MSCs can effectively reverse the physiological function of EAT thyroid tissue and reduce the accumulation of circulating antibodies in the body. in comparison, hUC-MSCs under LIFPUS pretreatment showed more desirable therapeutic potential. hUC-MSCs transplanted under LIFPUS pretreatment may be a new class of safe therapeutic modality for the treatment of AIT.
Investigating the Activity of Indole-2-on Derivative Src Kinase Inhibitors Against
Chronic Myeloid Leukemia Cells
Authors: Olgen Sureyya , Cort-Donmez Aysegul , Guner Ersin , Akgun-Cagliyan Gulsum , Hanikoglu Ferhat , Tunc-Ata Melek , Kilic-Toprak Emine
Published: May 2022

Background:

Src family tyrosine kinases play a potential role in Bcr-Abl-induced leukemogenesis. Src
kinase inhibitors are reported as selective inhibitors of chronic myeloid leukemia.

Objective:

Since Src kinase inhibitors have an inhibitive effect on chronic myeloid leukemia, indole derivatives (C-1,
C-2, C-3) previously found as potent inhibitors of Src kinase were tested against chronic myeloid leukemia in this
study.

Methods:

Cell viability of K562 and R/K562 cells, antiproliferative and antioxidant effects, and inhibition profiles of
Bcr-Abl kinase of indole derivatives were determined compared to dasatinib and imatinib.

Results:

The results showed that compounds affected cell proliferation and decreased the levels of Bcr/Abl. These results confirmed that the antileukemic activity of compounds was related to Bcr/Abl expression. Docking studies also presented that compounds are inhibitors of both Src and Abl kinases. Calculation of drug-like properties showed that compounds could be potential drug candidates.

Conclusion:

Among indole-2-on derivatives, previously identified as Src kinase inhibitors, C-2 has been discovered to
be a strong anticancer drug that is active against susceptible and resistant K562 cell lines and induces apoptosis.
A Recent Advancement in Nanotechnology Approaches for the Treatment of Cervical
Cancer
Authors: Theivendren Panneerselvam , Hegde Yashoda Mariappa , Srinivas Geetha , Palanivel Monashilpa , Shanmugam Nivetha , Kunjiappan Selvaraj , Vellaichamy Sivakumar , Gopal Murugananthan , Dharmalingam Senthil Rajan
Published: May 2022

Background:

Cervical cancer is one of the leading causes of female death, with a mortality rate of over
200,000 per year in developing countries. Despite a decrease in cervical cancer occurrences in developed countries
over the last decade, the frequency of the disease in developing nations continues to rise at an alarming rate, particularly
when it is linked to the human papillomavirus (HPV). With just a few highly invasive conventional therapies available,
there is a clear need for novel treatment options such as nanotechnology-based chemotherapeutic drug delivery.

Current limitations:

Traditional anticancer therapy is limited by poor drug potency, non-specificity, unwanted side
effects, and the development of multiple drug resistance (MDR), leading to a decrease in long-term anticancer therapeutic
efficacy. An ideal cancer therapy requires a personalized and specialized medication delivery method capable of
eradicating even the last cancer cell responsible for disease recurrence.

Purpose:

Nanotechnology provides effective drug delivery mechanisms, allowing it to serve both therapeutic and
diagnostic purposes. Nanotechnology-based formulations are widely used to accurately target the target organ, maintain
drug load bioactivity, preferentially accumulate the drug at the target location, and reduce cytotoxicity.

Future perspectives:

The key benefits of this drug delivery are that it improves pharmacological activity, solubility,
and bioavailability and reduces toxicity in the target tissue by targeting ligands, allowing for new innovative treatment
methods in an area that is desperately required. The goal of this review is to highlight possible research on nanotechnology-
based delivery systems for cancer detection and treatment.
The Glutaminase Inhibitor Compound 968 Exhibits Potent In vitro and In vivo
Anti-tumor Effects in Endometrial Cancer
Authors: Sheng Xiugui , Yuan Lingqin , Guo Hui , Li Wanhu , Pan Guoyou , Wang Cong , Li Dapeng , Liu Naifu
Published: May 2022

Background:

Glutamine is one of the primary nutrients utilized by cancer cells for energy production and biosynthesis. Hence, interfering with glutamine metabolism may impose anti-tumor effects.

Objective:

In this study, we assessed the anti-tumorigenic effects of glutaminase-1 enzyme (GLS1) inhibition in endometrial cancer in vitro and in vivo.

Methods:

The human endometrial cancer cell lines Ishikawa and HEC-1B were used. The effects of compound 968 on cell proliferation, cell cycle, apoptosis, cellular stress, and AKT/mTOR pathway inhibition were assessed. The synergistic effects of compound 968 and paclitaxel was also analyzed. The in vivo effect of compound 968 was evaluated using tumor xenografts.

Results:

We found that the GLS1-targeting compound 968 was able to reduce cancer cell proliferation in a dose- and time-dependent manner. Compound 968 combined with low concentration of paclitaxel showed stronger inhibitory effects. Further analyses indicated that compound 968 induced cell cycle arrest at the G1 phase, as well as increased the production of cellular reactive oxygen species (ROS) and promoted cellular stress and cancer cell apoptosis. Additionally, the treatment of endometrial cancer with compound 968 downregulated the expression of GLS1 and cyclin D1, and upregulated the expression of P21 and E-cadherin. Moreover, the treatment of endometrial cancer cells with compound 968 significantly reduced levels of phospho-S6 ribosomal protein and phospho-AKT (Ser473), indicative of AKT/mTOR/S6 signaling pathway inhibition. In xenograft mouse models of endometrial cancer, compound 968 significantly suppressed tumor growth. In addition, western blotting analysis indicated that GLS1 expression was upregulated in human endometrial cancer tissues.

Conclusion:

Compound 968 may be a promising approach for the management of human endometrial cancer.
Research on Incentive Mechanism and Credit Behavior of University
Scientific Research Based on Evolutionary Game
Authors: Xuwang Liu , Yujie Zhang , Zhengxuan Zhang
Published: May 2022

Background:

Colleges and universities are the important support of national scientific and technological innovation, and research productions are the comprehensive embodiment of their strength. How to mobilize the enthusiasm of researchers and create a good atmosphere for researchers have research value.

Objective:

On the premise of the bounded rationality of researchers, this paper first briefly describes some practical issues in the field of evaluation of scientific achievements, establishing two major research objects: researchers and scientific research management departments.

Methods:

: By using the evolutionary game theory, this study establishes a two-side evolutionary game model in combination with the factors that affect the decision of researchers, and it proves the preconditions for an evolutionarily stable strategy based on replication dynamic thought and the criterion of evolutionary stability strategy. Based on MATLAB GUI platform, this paper develops the numerical simulation system of research investment and reward strategy and realizes the quantitative processing of the theoretical model.

Results:

Firstly, the evolution speed of the researcher choosing high research investment and the scientific management department choosing high research reward strategy is related to the selection ratio of this strategy; then, there is hysteresis in both parties’ mastery of each other’s strategy information; finally, while optimizing the conditions for scientific research and punishing academic misconduct, the administrative departments should regularly adjust their assessment indicators to create a good atmosphere for scientific research

Conclusion:

This paper will further solve engineering problems in the field of scientific research management.
Therapeutic Potential of a Bioactive Flavonoids Glycitin from Glycine
max: A Review on Medicinal Importance, Pharmacological Activities and
Analytical Aspects
Authors: Patel Dinesh Kumar
Published: May 2022

Background:

Soybean (Glycine max (L.) Merr.) is an important industrial crop and fourth major crop in the world which are the richest source of isofavones including glycitein in human diet. Soybean has been associated with beneficial effects in prevention of cancer, osteoporosis, cardiovascular diseases and menopausal symptoms. Isoflavones class phytochemicals has been extensively studied in the scientific fields due to its estrogenic potential.

Methods:

Scientific information of glycitin for their biological potential and therapeutic effects has been collected and analyzed in the present work. Scientific data of glycitin has been collected from electronic databases such as Google, Google Scholar, PubMed, Science Direct, and Scopus in the present work and analyzed for their therapeutic potential. Detailed pharmacological activities and analytical data of glycitin has been collected from these databases using term flavonoid and glycitin and analyzed.

Results:

Scientific data analysis revealed the biological importance and therapeutic benefit of glycitin in the medicine. Glycitin also called 4′-hydroxy-6-methoxyisoflavone-7-D-glucoside have been found to present in the Soy products. Glycitin exhibit chemo-preventive, cardio-protective and anti-osteoporosis effects. Glycitin revealed their beneficial effects on diabetes, acute lung injury, bone, cognitive performance, breast cancer, skin, immune system, enzymes, prostaglandin and taste receptors. However its ligand binding assay, cytoprotective effect and pharmacokinetic parameters were also studied in the present work. Analytical data signified the importance of analytical tools for qualitative and quantitative analysis of glycitin in the medicine.

Conclusion:

Scientific data analysis revealed the therapeutic effectiveness of glycitin in the medicine.
A Charging and Discharging Model for Electric Vehicles based on Consortium
Blockchain Using Multi-Objective Gray Wolf Algorithm
Authors: Li Yuancheng , Shang Xingyu , Huang Rong
Published: May 2022

Background:

As many EVs (EVs) are connected to the grid, transactions between EVs and the grid will have problems such as poor privacy and affecting the stability of the grid. This paper uses consortium blockchain to design a safe and privacy-preserving scheme for the two-way power transaction between EVs and the grid.

Objective:

: To reduce the adverse impact of disorderly charging of large-scale EVs on the power grid, the total load variance is minimized by optimizing EVs' charging/discharging period.

Methods:

We propose to use a heuristic algorithm, an improved multi-objective gray wolf algorithm, to solve this problem.

Results:

The simulation results show that the model can effectively smooth load fluctuations and improve user benefits.

Conclusion:

Our method can effectively reduce the load fluctuation of the grid while ensuring the economic benefits of users. Qualitative security and privacy analysis show that the solution helps to improve the security and privacy of electricity transactions.
Detailed Study on Electronic Data Energy Consumption Monitoring System
Based on the Construction of Internet of Things
Authors: Kumar Khushmeet , Yu Ruiling , Smail Boussaadi , ER Rakesh Kumar , Lal Sujesh P.
Published: May 2022

Background:

Buildings, in the traditional sense, are becoming increasingly incapable
of meeting modern humans’ pursuit of high-quality living and working environments. With the
increasing pace of urban development, modern buildings are becoming increasingly popular.

Objective:

We investigate an electronic data energy consumption monitoring system based on the
construction of Internet of Things for the airport building.

Aim:

A model based on Dynamic Programming Genetic Algorithm (DPGA) is proposed to generate parameter and service models based on user scenarios.

Methods:

Two definitions are presented for the communication format between the middleware
and the Wireless Sensor Network (WSN); the software and hardware functions of the nodes of the
system's WSN are designed, and part of the node is implemented. Finally, the specific implementation of the application program interface and data interface between the modules of the middleware system are described considering the internal environment of a typical office building as an
example. The deployment plan of system nodes in specific environments and the division of similar areas are discussed

Results:

The platform can strictly monitor and manage energy-consuming equipment.

Conclusion:

The proposed model can be used to achieve reasonable distribution of energy consumption, energy saving, and humanised and automated energy consumption monitoring functions in the office areas of large office buildings in modern cities.
The Economic of Mini Purse Seine Fisheries by Season and Fishing Ground in Kei Island
Authors:   Department of Fishery Products Technology, Tual State Fisheries Polytechnic, Langgur, Southeast Maluku Regency, Maluku Province, Indonesia, Picaulima Simon Marsholl , Wiyono Eko Sri ,   Department of Fisheries Resources Utilization, Faculty of Fisheries and Marine Sciences, Bogor Agricultural University, Bogor, West Java Province, Indonesia, Rahantoknam Meyske Angel ,   Department of Fishery Products Technology, Tual State Fisheries Polytechnic, Langgur, Southeast Maluku Regency, Maluku Province, Indonesia, Notanubun Julianus ,   Department of Fishery Products Technology, Tual State Fisheries Polytechnic, Langgur, Southeast Maluku Regency, Maluku Province, Indonesia
Published: May 2022

The economic profit of mini purse seine fishing business in the coastal area of the Kei Islands is different in every season and fishing ground. The aim.of.this analyze the profit of the mini purse seine fishing business on every season and on fishing grounds. Collecting data using survey methods, determining respondents using purposive sampling. Data were analyzed using fishing ground analysis and economic analysis. The results of.the identification indicate that during the transitional season 1 and west, the mini purse seine fishing ground are located on the eastern coast of Tayando and eastern Kei Besar coast and the Nerong strait. The result of the identification shows that the fishing grounds of mini purse seine in the western and transitional 1 seasons in the waters of the eastern Tayando Island, the Nerong Strait, and the waters of the eastern Kei Besar Island, while at the beginning of.the east monsoon in the waters of.the eastern part of Tayando Island and the Nerong Strait.The.results.of.the.economic.analysis.show.that the fishing grounds waters of.the eastern Tayando Islandhaves higher economic profit in each season because it has low efficiency, effectiveness, productivity, and high business profit. Fisheries managers in Maluku Province need to work together with fishermen to regulate production inputs in the fishing grounds of the Nerong Strait every season.
Factors That Influence the Performance of Class II Fish Auction in Pati Regency
Authors:   Departement of Aquatic Resources, Faculty of Fisheries and Marine Science, Diponegoro University, Prof. H. Soedarto, S.H. Street, Tembalang, Semarang City, Central Java, Indonesia, Damayanti Herna Octivia , Saputra Suradi Wijaya , Wijayanto Dian , Mudzakir Abdul Kohar ,   Departement of Aquatic Resources, Faculty of Fisheries and Marine Science, Diponegoro University, Prof. H. Soedarto, S.H. Street, Tembalang, Semarang City, Central Java, Indonesia
Published: May 2022

The Fish Auction Place has a function as a marketing place for fishermen’s catches through the auction process. The auction activities carried out by the Class II TPI in Pati Regency showed that the performance was not optimal. The purpose of this research was to analyze the factors that influence the performance of class II fish auctions place in the Pati Regency. The research locations were the Banyutowo Fish Auction Place and the Puncel Fish Auction Place. Research time was held from January to October 2021. The number of research samples was 110 respondents. Data analysis with Structural Equation Modeling with AMOS software. The results showed that the factors that influence the performance of class II fish auctions place were planning, organizing, actuating, and controlling. These four variables have a positive and significant effect on the performance of class II fish auctions placed in the Pati Regency. The driving factor has the greatest influence on the performance of class II fish auctions in the Pati Regency with a standard regression coefficient value of 0.365. If actuating is getting better, the achievement of performance indicators was higher. On the other hand, if actuating gets weaker, the achievement of performance indicators was lower. Thus, the actuating factor needs to get greater attention in the management of the class II fish auction place in Pati Regency.
Economic Analysis and Carrying Capacity of the Bontang Mangrove Park Ecotourism Area Kutai National Park in East Kalimantan
Authors:   PS. Ekonomi Pembangunan Jurusan Ilmu Ekonomi, Fakultas Ekonomi dan Bisnis Universitas Mulawarman, Safri Rina Marsela , Amalia Siti ,   Fakultas Ekonomi dan Bisnis, Universitas Mulawarman, Auliansyah Auliansyah ,   Fakultas Ekonomi dan Bisnis, Universitas Mulawarman
Published: May 2022

The Bontang Mangrove Park (BMP) area is an ecotourism area within the Kutai National Park, East Kalimantan. As an ecotourism area, research was conducted with the aim of calculating the economic value, carrying capacity of the area, and seeing how BMP contributes economically to the surrounding population. The objectives are answered with a qualitative descriptive approach and a quantitative descriptive approach, using the Travel Cost Method analysis tool based on the visitor's origin zone and carrying capacity analysis. Based on the results of the analysis, the economic value of BMP reaches IDR 6,471,315,944/year. The carrying capacity of BMP for mangrove tracking tourism activities is 280 people/day, and boating tourism is 90 people/day. Economic contribution to people's income in October IDR 10,277,400, November and December IDR 13,477,400 then the overall result of the economic contribution for 3 months becomes IDR 117,122,000.
Ethical, Legal, and Social Implications of Symptom Checker Apps in Primary Health Care (CHECK.APP): Protocol for an Interdisciplinary Mixed Methods Study
Authors: Wetzel Anna-Jasmin , Koch Roland , Preiser Christine , Müller Regina , Klemmt Malte , Ranisch Robert , Ehni Hans-Jörg , Wiesing Urban , Rieger Monika A , Henking Tanja , Joos Stefanie
Published: May 2022

Background

Symptom checker apps (SCAs) are accessible tools that provide early symptom assessment for users. The ethical, legal, and social implications of SCAs and their impact on the patient-physician relationship, the health care providers, and the health care system have sparsely been examined. This study protocol describes an approach to investigate the possible impacts and implications of SCAs on different levels of health care provision. It considers the perspectives of the users, nonusers, general practitioners (GPs), and health care experts.

Objective

We aim to assess a comprehensive overview of the use of SCAs and address problematic issues, if any. The primary outcomes of this study are empirically informed multi-perspective recommendations for different stakeholders on the ethical, legal, and social implications of SCAs.

Methods

Quantitative and qualitative methods will be used in several overlapping and interconnected study phases. In study phase 1, a comprehensive literature review will be conducted to assess the ethical, legal, social, and systemic impacts of SCAs. Study phase 2 comprises a survey that will be analyzed with a logistic regression. It aims to assess the user degree of SCAs in Germany as well as the predictors for SCA usage. Study phase 3 will investigate self-observational diaries and user interviews, which will be analyzed as integrated cases to assess user perspectives, usage pattern, and arising problems. Study phase 4 will comprise GP interviews to assess their experiences, perspectives, self-image, and concepts and will be analyzed with the basic procedure by Kruse. Moreover, interviews with health care experts will be conducted in study phase 3 and will be analyzed by using the reflexive thematical analysis approach of Braun and Clark.

Results

Study phase 1 will be completed in November 2021. We expect the results of study phase 2 in December 2021 and February 2022. In study phase 3, interviews are currently being conducted. The final study endpoint will be in February 2023.

Conclusions

The possible ethical, legal, social, and systemic impacts of a widespread use of SCAs that affect stakeholders and stakeholder groups on different levels of health care will be identified. The proposed methodological approach provides a multifaceted and diverse empirical basis for a broad discussion on these implications.

Trial Registration

German Clinical Trials Register (DRKS) DRKS00022465; https://tinyurl.com/yx53er67

International Registered Report Identifier (IRRID)

DERR1-10.2196/34026
Skin Cancer Narratives on Instagram: Content Analysis
Authors: Gomaa Basma , Houghton Rebecca F , Crocker Nicole , Walsh-Buhi Eric R
Published: May 2022

Background

Skin cancer is among the deadliest forms of cancer in the United States. The American Cancer Society reported that 3 million skin cancer cases could be avoided every year if individuals are more aware of the risk factors related to sun exposure and prevention. Social media platforms may serve as potential intervention modalities that can be used to raise public awareness of several diseases and health conditions, including skin cancer. Social media platforms are efficient, cost-effective tools for health-related content that can reach a broad number of individuals who are already using these spaces in their day-to-day personal lives. Instagram was launched in 2010, and it is now used by 1 billion users, of which 90% are under the age of 35 years. Despite previous research highlighting the potential of image-based platforms in skin cancer prevention and leveraging Instagram’s popularity among the priority population to raise awareness, there is still a lack of studies describing skin cancer–related content on Instagram.

Objective

This study aims to describe skin cancer–related content on Instagram, including the type of account; the characteristics of the content, such as the kind of media used; and the type of skin cancer discussed. This study also seeks to reveal content themes in terms of skin cancer risks, treatment, and prevention.

Methods

Through CrowdTangle, a Facebook-owned tool, we retrieved content from publicly available accounts on Instagram for the 30 days preceding May 14, 2021. Out of 2932 posts, we randomly selected 1000 posts for review. Of the 1000 posts, 592 (59.2%) met the following inclusion criteria: (1) content was focused on human skin cancer, (2) written in English language only, and (3) originated from the United States. Guided by previous research and through an iterative process, 2 undergraduate students independently coded the remaining posts. The 2 coders and a moderator met several times to refine the codebook.

Results

Of the 592 posts, profiles representing organizations (n=321, 54.2%) were slightly more common than individual accounts (n=256, 43.2%). The type of media included in the posts varied, with posts containing photos occurring more frequently (n=315, 53.2%) than posts containing infographics (n=233, 39.4%) or videos (n=85, 14.4%). Melanoma was the most mentioned type of skin cancer (n=252, 42.6%). Prevention methods (n=404, 68.2%) were discussed in Instagram posts more often than risk factors (n=271, 45.8%). Only 81 out of 592 (13.7%) posts provided a citation.

Conclusions

This study’s findings highlight the potential role of Instagram as a platform for improving awareness of skin cancer risks and the benefits of prevention practices. We believe that social media is the most promising venue for researchers and dermatologists to dedicate their efforts and presence that can widely reach the public to educate about skin cancer and empower prevention.
Attitudes of Patients With Chronic Heart Failure Toward Digital Device Data for Self-documentation and Research in Germany: Cross-sectional Survey Study
Authors: Buhr Lorina , Kaufmann Pauline Lucie Martiana , Jörß Katharina
Published: May 2022

Background

In recent years, the use of digital mobile measurement devices (DMMDs) for self-documentation in cardiovascular care in Western industrialized health care systems has increased. For patients with chronic heart failure (cHF), digital self-documentation plays an increasingly important role in self-management. Data from DMMDs can also be integrated into telemonitoring programs or data-intensive medical research to collect and evaluate patient-reported outcome measures through data sharing. However, the implementation of data-intensive devices and data sharing poses several challenges for doctors and patients as well as for the ethical governance of data-driven medical research.

Objective

This study aims to explore the potential and challenges of digital device data in cardiology research from patients’ perspectives. Leading research questions of the study concerned the attitudes of patients with cHF toward health-related data collected in the use of digital devices for self-documentation as well as sharing these data and consenting to data sharing for research purposes.

Methods

A cross-sectional survey of patients of a research in cardiology was conducted at a German university medical center (N=159) in 2020 (March to July). Eligible participants were German-speaking adult patients with cHF at that center. A pen-and-pencil questionnaire was sent by mail.

Results

Most participants (77/105, 73.3%) approved digital documentation, as they expected the device data to help them observe their body and its functions more objectively. Digital device data were believed to provide cognitive support, both for patients’ self-assessment and doctors’ evaluation of their patients’ current health condition. Interestingly, positive attitudes toward DMMD data providing cognitive support were, in particular, voiced by older patients aged >65 years. However, approximately half of the participants (56/105, 53.3%) also reported difficulty in dealing with self-documented data that lay outside the optimal medical target range. Furthermore, our findings revealed preferences for the self-management of DMMD data disclosed for data-intensive medical research among German patients with cHF, which are best implemented with a dynamic consent model.

Conclusions

Our findings provide potentially valuable insights for introducing DMMD in cardiovascular research in the German context. They have several practical implications, such as a high divergence in attitudes among patients with cHF toward different data-receiving organizations as well as a large variance in preferences for the modes of receiving information included in the consenting procedure for data sharing for research. We suggest addressing patients’ multiple views on consenting and data sharing in institutional normative governance frameworks for data-intensive medical research.
Ethical, Legal, and Social Implications of Symptom Checker Apps in Primary Health Care (CHECK.APP): Protocol for an Interdisciplinary Mixed Methods Study (Preprint)
Authors: Wetzel Anna-Jasmin , Koch Roland , Preiser Christine , Müller Regina , Klemmt Malte , Ranisch Robert , Ehni Hans-Jörg , Wiesing Urban , Rieger Monika A , Henking Tanja , Joos Stefanie
Published: May 2022

BACKGROUND

Symptom checker apps (SCAs) are accessible tools that provide early symptom assessment for users. The ethical, legal, and social implications of SCAs and their impact on the patient-physician relationship, the health care providers, and the health care system have sparsely been examined. This study protocol describes an approach to investigate the possible impacts and implications of SCAs on different levels of health care provision. It considers the perspectives of the users, nonusers, general practitioners (GPs), and health care experts.

OBJECTIVE

We aim to assess a comprehensive overview of the use of SCAs and address problematic issues, if any. The primary outcomes of this study are empirically informed multi-perspective recommendations for different stakeholders on the ethical, legal, and social implications of SCAs.

METHODS

Quantitative and qualitative methods will be used in several overlapping and interconnected study phases. In study phase 1, a comprehensive literature review will be conducted to assess the ethical, legal, social, and systemic impacts of SCAs. Study phase 2 comprises a survey that will be analyzed with a logistic regression. It aims to assess the user degree of SCAs in Germany as well as the predictors for SCA usage. Study phase 3 will investigate self-observational diaries and user interviews, which will be analyzed as integrated cases to assess user perspectives, usage pattern, and arising problems. Study phase 4 will comprise GP interviews to assess their experiences, perspectives, self-image, and concepts and will be analyzed with the basic procedure by Kruse. Moreover, interviews with health care experts will be conducted in study phase 3 and will be analyzed by using the reflexive thematical analysis approach of Braun and Clark.

RESULTS

Study phase 1 will be completed in November 2021. We expect the results of study phase 2 in December 2021 and February 2022. In study phase 3, interviews are currently being conducted. The final study endpoint will be in February 2023.

CONCLUSIONS

The possible ethical, legal, social, and systemic impacts of a widespread use of SCAs that affect stakeholders and stakeholder groups on different levels of health care will be identified. The proposed methodological approach provides a multifaceted and diverse empirical basis for a broad discussion on these implications.

CLINICALTRIAL

German Clinical Trials Register (DRKS) DRKS00022465; https://tinyurl.com/yx53er67

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/34026
Identifying Patients With Hypoglycemia Using Natural Language Processing: Systematic Literature Review (Preprint)
Authors: Zheng Yaguang , Dickson Victoria Vaughan , Blecker Saul , Ng Jason M , Rice Brynne Campbell , Melkus Gail D’Eramo , Shenkar Liat , Mortejo Marie Claire R , Johnson Stephen B
Published: May 2022

BACKGROUND

Accurately identifying patients with hypoglycemia is key to preventing adverse events and mortality. Natural language processing (NLP), a form of artificial intelligence, uses computational algorithms to extract information from text data. NLP is a scalable, efficient, and quick method to extract hypoglycemia-related information when using electronic health record data sources from a large population.

OBJECTIVE

The objective of this systematic review was to synthesize the literature on the application of NLP to extract hypoglycemia from electronic health record clinical notes.

METHODS

Literature searches were conducted electronically in PubMed, Web of Science Core Collection, CINAHL (EBSCO), PsycINFO (Ovid), IEEE Xplore, Google Scholar, and ACL Anthology. Keywords included hypoglycemia, low blood glucose, NLP, and machine learning. Inclusion criteria included studies that applied NLP to identify hypoglycemia, reported the outcomes related to hypoglycemia, and were published in English as full papers.

RESULTS

This review (n=8 studies) revealed heterogeneity of the reported results related to hypoglycemia. Of the 8 included studies, 4 (50%) reported that the prevalence rate of any level of hypoglycemia was 3.4% to 46.2%. The use of NLP to analyze clinical notes improved the capture of undocumented or missed hypoglycemic events using International Classification of Diseases, Ninth Revision (ICD-9), and International Classification of Diseases, Tenth Revision (ICD-10), and laboratory testing. The combination of NLP and ICD-9 or ICD-10 codes significantly increased the identification of hypoglycemic events compared with individual methods; for example, the prevalence rates of hypoglycemia were 12.4% for International Classification of Diseases codes, 25.1% for an NLP algorithm, and 32.2% for combined algorithms. All the reviewed studies applied rule-based NLP algorithms to identify hypoglycemia.

CONCLUSIONS

The findings provided evidence that the application of NLP to analyze clinical notes improved the capture of hypoglycemic events, particularly when combined with the ICD-9 or ICD-10 codes and laboratory testing.
Lifestyle interventions after colorectal cancer surgery using a mobile digital device: a study protocol for a randomized clinical trial (Preprint)
Authors: Kim Young Il , Park In Ja , Kim Chan Wook , Yoon Yong Sik , Lim Seok-Byung , Yu Chang Sik , Kim Jin Cheon , Lee Yura , Kim Harin , Chung Seockhoon , Choi Chang-Min , Lee Hui Jeong , Kim Kyung Won , Ko Yousun , Yun Sung-Cheol , Jo Min-Woo , Lee Jong Won
Published: May 2022

BACKGROUND

In treating colorectal cancer, surgical techniques and adjuvant treatments have advanced over the past century, but relatively less attention has been given to improve health-related quality of life (HRQOL). Recent studies report a significant association between cancer recurrence and patient lifestyle after surgery, hence emphasizing the need to assist patients to reduce this risk through appropriate lifestyle choices.

OBJECTIVE

The proposed study will evaluate the effects of digital interventions on lifestyle after surgery for colorectal cancer using mobile applications.

METHODS

A randomized controlled trial (RCT) design was proposed. A total of 320 patients diagnosed with colorectal cancer aged between 20 to 70 years were to be enrolled and randomized in equal numbers into four groups (three groups assigned to different mobile applications and a control group). Surveys that evaluate HRQOL, physical measurements, and metabolic parameters (fasting glucose, HbA1c, triglyceride, HDL cholesterol), and fat/muscle mass measurements by abdominal computed tomography (CT), will be conducted prior to surgery and every 6 months post-surgery for 18 months. Statistical analysis will be used to compare the outcomes between groups.

RESULTS

As of December 2021, enrollment of trial was completed with a total of 313 patients. Baseline clinicopathologic characteristics were comparable between the 4 randomized groups.

CONCLUSIONS

Results from this study could provide evidence that easily accessible mobile applications can influence patient lifestyles. Results showing minimal effects of such applications could also be constructive for improving healthcare-related applications.

CLINICALTRIAL

https://cris.nih.go.kr: KCT0005447. Registration date: June 23, 2020. This study protocol has been approved by the Institutional Review Board on July 8, 2021 (2020-1015).