bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic documentation of the introduction of COVID-19 vaccines in Latin America and the Caribbean
Authors: Jimbo-Sotomayor Ruth , da Costa Oliveira María Tereza , Acurio Luciana Armijos , Bastías Magdalena , Carvalho Marcia , Sánchez Xavier , de Oliveira Lucia Helena
Published: May 2024

Objective.

To document the process of introducing COVID-19 vaccines in a selection of Latin American and Caribbean countries, including the lessons learned and the strengths and weaknesses, and similarities and differences among programs.

Methods.

This descriptive study is based on a systematic evaluation of the process of introducing COVID-19 vaccines in Argentina, Belize, Brazil, Costa Rica, Panama and Peru. Data were collected through a questionnaire distributed to key stakeholders. Six informants from each of the included countries participated in this study. The period of the study was from December 2021 through September 2022.

Results.

The main strengths reported by countries were health workers’ commitment to delivering vaccinations, evidence-based decision-making, the development of plans for vaccine introduction, the participation of national immunization technical advisory groups, the availability of economic resources and positive actions from the respective Ministry of Health. The main challenges were the actions of antivaccination groups, problems with electronic immunization registries, a lack of vaccines, delays in the delivery of vaccines and the scarcity of health personnel at the local level.

Conclusions.

Commitment, the participation of multiple sectors, the availability of resources and preparedness planning were some of the many strengths shown by countries introducing COVID-19 vaccines. Weaknesses included third parties’ interests, the lack of information systems and difficulty in accessing vaccines and vaccine services. There is a window of opportunity for countries to maintain the good practices that allowed for the processes’ strengths and to assess the identified weaknesses to invigorate immunization programs and prepare for future health crises.
Perwatakan dan Nilai Moral Tokoh Utama dalam Kumpulan Dongeng Ludwig Bechstein
Authors: Asiska Milasari , Mannahali Misnah
Published: May 2024

Abstract. This research purpose the value of character building in the drama Nathan der Weise, and its  relevance to German lessons at SMA.  The data analysus technique used is content analysis. This analysis technique consists of there stages.  They are data reduction, data display and conclusion. Based  on the result obtained from the Fed analysis that there are six values in the Drama Nathan der Weise that are relevant to the value of character building snd the German lesson Kurikulum 2013 at SMA. The six values are wisdom, tolerance, self-confidance, humalitiy, mutual help, and friendship. The relevance of these six values to German lessons using the role-playing method.Keywords: Nathan der Weise, Character buiding, Kurikulum 2013, Role-playing, Conten-Analysis.
Model Pembelajaran Team Assisted Individualization dalam Keterampilan Menulis Bahasa Jerman
Authors: Afidah Andi Nurul Fhadillah Ainun , Mannahali Misnah , Achmad Abd Kasim
Published: May 2024

Abstract. The purpose of this study was to determine the improvement in writing skills of German language texts for class XI students of SMAN 3 Makassar through the application of the Team Assisted Individualization model. This type of research is classroom action research which consists of two cycles with each cycle consisting of two meetings. The subject of this research is class XI MIPA 3 SMAN 3 Makassar. There are two types of research data, namely qualitative data and quantitative data. Qualitative data were obtained from teacher and student observation data, while quantitative data were obtained from students' writing tests. The results of students' text writing tests in cycle 1 obtained an average of 3 and experienced an increase in cycle II with an average value of 5. The results of this study indicate that the application of the Team Assisted Individualization model can improve the German writing skills of class XI students of SMAN 3 Makassar.Keyword: Implementation, Writing, Team Assisted Individualization model
Aedes albopictus is a competent vector of five arboviruses affecting human health, greater Paris, France, 2023
Authors: Bohers Chloé , Vazeille Marie , Bernaoui Lydia , Pascalin Luidji , Meignan Kevin , Mousson Laurence , Jakerian Georges , Karch Anaïs , de Lamballerie Xavier , Failloux Anna-Bella
Published: May 2024

Aedes albopictus collected in 2023 in the greater Paris area (Île-de-France) were experimentally able to transmit five arboviruses: West Nile virus from 3 days post-infection (dpi), chikungunya virus and Usutu virus from 7 dpi, dengue virus and Zika virus from 21 dpi. Given the growing number of imported dengue cases reported in early 2024 in France, surveillance of Ae. albopictus should be reinforced during the Paris Olympic Games in July, when many international visitors including from endemic countries are expected.
Предлежание плаценты - современное акушерство актуальная проблема на практике
Authors: D.F. Gurbanova  , A.A. Gasimova  , A.F. Amirova  , S.F. Alizade
Published: May 2024

Предлежание плаценты (рlacenta previa) -является одной из серьезных и актуальных проблем современного акушерства. В литературе «рlacenta previa» рассматривается как аномальное расположение плаценты, которое в 34% случаев во время беременности, в 66% случаях во время родов приводит к возникновению массивных аку-шерских кровотечений. Необходимо подчерк- нуть, что возникновение массивных кровотечений требует принятия радикальных мер, вплоть до тотальной гистерэктомии. Нередко «рlacenta previa» является основной причиной материнской и перинатальной смертности [1-3].
Harmonisasi Kehidupan Masyarakat Beragama pada Lingkungan Gated Community di Kelurahan Panggungharjo Yogyakarta
Authors: Fitrianatsany Fitrianatsany
Published: May 2024

Living harmoniously in religious communities is crucial to fostering amicable relationships between different religious groups, especially in gated communities. A  gated community is a diverse group of people from different ethnicities, religions, and cultures living together. Gated communities offer comfortable, safe, and exclusive housing with security systems, such as a gate arrangement. They also provide public facilities like green open spaces and even a place of worship for residents. This study uses qualitative research methods to explore the development trends of gated communities and how religious life can harmonized within them. The results of this research show that millennials living in  gated community complexes view many communities as exclusive, and they do not find these gated communities appealing. However, they still live in harmony with the residents by smiling, greeting each other, being polite, and welcoming to everyone. Additionally, residents of these communities use public facilities for routine gatherings and social-religious activities to strengthen kinship and promote harmony between residents.Abstrak: Kehidupan masyarakat beragama yang harmonis menjadi kunci dalam sebuah kerukunan hidup antar umat beragama pada umumnya dan khususnya di lingkungan  gated community atau yang sering disebut sebagai komunitas berpagar.  gated community merupakan tempat bermukim masyarakat dengan beragam suku bangsa, agama dan juga budaya. Selain itu,  gated community juga menawarkan hunian yang nyaman dan aman serta ekslusif dengan menawarkan sistem keamanan seperti one gate system. Di dalamnya juga menawarkan fasilitas umum seperti ruang terbuka hijau dan bahkan tempat ibadah bagi para penghuninya. Penelitian ini menggunakan metode penelitian kualitatif untuk melihat lebih dalam terkait dengan tren perkembangan  gated community dan harmonisasi kehidupan beragama masyarakat  gated community di Kelurahan Panggungharjo Yogyakarta. Hasil yang didapat dalam penelitian ini adalah kehidupan kaum milenial yang bermukim di kompleks  gated community atau perumahan yang notabene di konstruks oleh masyarakat luas sebagai masyarakat yang ekslusif dan individual ternyata tidak ditemukan di komunitas berpagar tersebut. Mereka justru menerapkan hidup rukun dengan para warga dengan saling senyum, sapa, sopan, ramah dan tamah kepada setiap orang. Selanjutnya warga hunian tersebut juga memanfaatkan fasilitas umum untuk perkumpulan rutin dan kegiatan sosial keagamaan yang bertujuan untuk mempererat tali persaudaraan dan kerukunan antar warga.
Projected performance of green infrastructure strategies for flood mitigation in the Ganges-Brahmaputra-Meghna delta
Authors: Diarra Hakiri , Agravante Gerard Jaque Bulan , Pretorius Elizabeth , Widyadharma Hadikusu Giancarlo Mahen
Published: May 2024

Background: The Ganges-Brahmaputra-Meghna (GBM) delta – the world’s most populous river delta – faces heightened susceptibility to the rise in flooding disasters due to climate change, impacting millions annually. Current flood management strategies are unsustainable and ineffective, and resilient flood management is needed. A promising alternative is the strategic implementation of green infrastructure (GI) applications, which have proven effective in flood management in other regions.
Methods: An analysis of the region’s past and future vulnerability to flooding is conducted. Then, green infrastructure performance metrics from regions with similar climatic conditions are extrapolated for the GBM. Green roofs, permeable pavements, and rain gardens were identified as the most suitable GI types for the GBM. Finally, computer simulations were employed to analyze the performance of different implementations of GI within a model city.
Results: The simulations showed that 0% green rooftop coverage, 100% permeable pavement coverage, and 40% rain garden coverage were the most feasible GI layout. This configuration resulted in the most preferable balance between cost effectiveness and reduced runoff. Green rooftops were minimized due to high installation costs relative to their retention capacity, whereas permeable pavements and rain garden coverage were maximized.
Conclusions: The studies show GI’s potential for flood mitigation and resilience in the GBM region. GI initiatives align with the region's flood mitigation policies and are thus feasible to implement with aid from government incentives. Furthermore, the computer program developed for this analysis could serve as a valuable tool for assessing GI implementation limits and offering guidance to policymakers.
A Present Vision for Artificial Insemination of Farm Animals in Egypt
Authors: Seioudy Ahmed , Koşum Nedim
Published: May 2024

It is well known that one of the major limitations in development of farm animals in Egypt is the extremely low reproductive efficiency. As a result, horizontal expansion would be impossible in dairy animals in Egypt. Therefore, such as in developing countries, artificial insemination (AI) programs are one of the most important options for fast development and genetic improvement in animal breeding studies in Egypt. Meanwhile, the proposed genetic improvement of buffalo milk production is being accelerated using an AI network. According to official statistics, Egypt has only two AI centers for selected buffalo sires, serving four AI units. Based on the current status of artificial insemination studies of farm animals in Egypt, this review spots the light on recent progresses in breeding of farm animals such as buffalo, camel, sheep and goat, based on a comprehensive scientific experience for more than a decade to get a better food security in Egypt.
ANALISIS EFISIENSI BOILER CFB UNIT 3 MENGGUNAKAN METODE LANGSUNG DI PT PLN INDONESIA POWER OMU JERANJANG
Authors: Joniarta I Wayan , Al Buhori Rashid Ridho , Made  Wijana
Published: May 2024

A Boilers play an important role as steam power plants. A boiler is a closed vessel that is used to produce pressurized steam, where the resulting pressurized steam is used outside the boiler itself. This research aims to find out how to analyze the efficiency of CFB boilers. The analytical method used is the direct method. The results obtained show that the efficiency value of CFB boiler unit 3 of PLTU Jeranjang with a load of 25.8 MW, namely 73.17%, is quite low, this is caused by a lack of steam flow as a result of a leak in the upper boiler of PLTU Jeranjang unit 3, causing steam to come out of boiler and reduces its efficiency.
The Potential of Burkholderia sp. from Zea mays Roots as Plant Growth Promoting Rhizobacteria
Authors: Mustami Muh. Khalifah , Hafsan Hafsan , Asri Asri
Published: May 2024

Plant Growth-Promoting Rhizobacteria (PGPR) plays a crucial role in enhancing plant health, while Burkholderia sp. has been identified and has potential as a promising PGPR for maize plants. Recognizing the essential role of PGPR in plant health, this study explores how L-TRP addition might improve PGPR performance for better plant growth. Employing a completely randomized design, the study assesses the effects of Burkholderia sp. as PGPR on maize growth across three treatment groups: PGPR with L-TRP, PGPR without L-TRP, and a control group. The evaluation focuses on plant growth metrics, plant hormone production (auxin and gibberellin), and siderophore activity to gauge plant iron availability. Statistical analysis highlights that L-TRP supplementation notably increases auxin production in the PGPR + L-TRP group, surpassing the PGPR without L-TRP and control groups. Although both PGPR treatments elevate gibberellin levels compared to the control, auxin increase is the most significant outcome, indicating no substantial difference in gibberellin levels between the two PGPR groups. Enhanced siderophore production suggests improved iron assimilation for plants. The findings demonstrate that L-TRP supplementation with PGPR, particularly Burkholderia sp., effectively boosts maize growth, primarily through increased auxin and siderophore production. This combination presents a promising strategy for augmenting agricultural yields, especially for maize productivity, by leveraging the synergistic effects of soil microbes and nutrient supplementation.
Colour blindness prevalence and its awareness in primary school children of Karachi.
Authors: Sassi Kanwal  , Ahtishsm Saleem  , Khulood Shahid  , Faiza Nasir  , Areeb Amir  , Syeda Bariah Hussain
Published: May 2024

Objective: To Assess and compare different types of color blindness in primary school children also to appraise the self-awareness levels regarding this ailment amongst them. Study Design: Cross Sectional study. Setting: Different Primary Schools of Karachi in Collaboration with Department of Physiology, Jinnah Medical and Dental College Karachi. Period: 1st October 2020 to 1st December 2020. Methods: 146 primary school children of both genders aged between 5 to 12 years were assessed by prescribed questionnaire and Ishahara Chart for color blindness. Result: Out of the 148 students who underwent screening, only 16 were diagnosed with color blindness, indicating a prevalence of 10.8% among primary school children in Karachi. Of these 16 students, males exhibited a higher incidence of color blindness (56.25%) than females (47.35%). Conclusion: The incidence of color blindness is higher in males than females with significant association with family history and night blindness. Colour blindness unawareness also significantly found in this study. It is recommended to have an eye checkup at the start of school and to have regular eye examination to avoid any hindrances and get the right help.
Clinical correlation of Magnetic Resonance Imaging (MRI) with symptom complex in prolapsed intervertebral disc disease in the patients of Tertiary Care Hospital, Kharian.
Authors: Maryam Latif  , Salahuddin Balooch  , Zeeshan Ali  , Umar Amin  , Muhammad Tarique  , Adil Qayyum
Published: May 2024

Objective: To assess the clinical correlation of MRI with the symptoms of prolapsed intervertebral disc disease in the patients of Tertiary Care Hospital, Kharian. Study Design: Cross Sectional study. Setting: Tertiary Care Hospital, Kharian. Period: February 2022 to August 2022. Methods: The patients with age range 18 to 50 years, visiting hospital with complaint of low back pain and radicular pain were included in this study. Physical and neurological examination was conducted followed by MRI. The symptoms were correlated with MRI findings through correlation analysis with p<0.05 as significant. Results: The mean age was 38.09 ± 8.4 years with majority (54.6%) of patients in age range 41 to 50 years. The male patients (69.3%) and hard labor workers (59.3%) were more effected. Protrusion was the most prevalent type (60%). SLR was significantly associated with disc bulge and protrusion (p<0.001). The loss of power (56.6%) had significant correlation with disc protrusion (p < 0.001). Majority (55.3%) of the cases comprised of nerve root compression with more (47.3%) and significant prevalence in protrusion (p < 0.001). The multiple nerve root involvement had significant association with disc extrusion (p<0.001). Conclusion: MRI is a good means of indicating disease level in prolapsed intervertebral disc disease. However, some of the clinical symptoms show high association with the radiological findings, whereas, some are not good indicators.
CURSO DE INTRODUÇÃO AO SIMULADOR sBotics
Authors: Gritta Dermeval Heitor Souza , Guimarães Vinicios Barbosa , Ferreira Joacir Simões
Published: May 2024

O projeto visa promover medidas para oferecer oportunidades, experiências técnicas e práticas para os discentes envolvidos na área de programação de robôs. Apesar de termos a noção da prática em labor
Sistema de potência de um ROV e suas falhas
Authors:   , Santos Matheus Rangel dos
Published: May 2024

Atualmente, pouco ou quase nada se tem disponível em relação ao sistema de potência de um ROV para consulta na internet. Logo, o objetivo desde trabalho é se aprofundar no sistema de potência, abordando todo o caminho desde os 440v fornecidos pela embarcação até a tensão final que alimenta os motores elétricos do Remotely Operated Vehicle e toda parte eletrônica/elétrica de baixa potência e abordando todas as possíveis falhas nos dimensionamentos dos equipamentos para preservação dos equipamentos e da segurança dos trabalhadores. Componentes como transformadores, Sliprings, cabo armado, caixa estática e caixa rotativa, caixa de terminação, garrafa eletrônica, serão os principais que iremos abordar nesse trabalho.
A REVOLUÇÃO DO DIAGNÓSTICO E TRATAMENTO DE CARDIOPATIAS POR MEIO DA INTELIGÊNCIA ARTIFICIAL
Authors: Souza Laiane Angélica Costa , Fonseca Breno Belizário da , Taveira Isabela Barros , Pereira Leonardo de Medeiros , Lima Matheus Silva , Ribeiro Vinícius Gomes , Bringel Fabiana de Andrade
Published: May 2024

Introdução: A crescente prevalência de doenças cardiovasculares destaca a necessidade de avanços no diagnóstico preciso e precoce das cardiopatias, que se mantêm como a principal causa de óbito tanto no Brasil quanto no mundo. Diante desse cenário desafiador, a inteligência artificial (IA) surge como uma ferramenta revolucionária, promovendo uma transformação significativa na abordagem médica. Seu escopo de atuação abrange desde o rastreamento de fatores de risco até a interpretação de exames de imagens, diagnóstico preciso e formulação de condutas personalizadas, sinalizando um potencial otimizador na prática clínica. Objetivo: Este estudo tem como propósito analisar as aplicações mais recentes da inteligência artificial no contexto da Cardiologia. O objetivo é não apenas mapear essas aplicações, mas também compreender a magnitude de seu impacto e os avanços significativos que ela trouxe para o diagnóstico e tratamento de doenças cardiovasculares. Metodologia: A condução deste estudo envolveu uma revisão integrativa de literatura, baseada na busca, coleta e análise de estudos científicos relevantes publicados entre os anos de 2019 e 2024. A produção da pesquisa envolveu algumas etapas, como a definição do questionamento da pesquisa, seleção da literatura, análise crítica dos estudos selecionados, síntese e apresentação da revisão. Esse método foi escolhido para fornecer uma visão abrangente e integrada das recentes contribuições da inteligência artificial no campo da Cardiologia. Resultados e Discussão: Os resultados obtidos revelam uma melhoria substancial na precisão diagnóstica quando comparada aos métodos tradicionais. Os algoritmos de inteligência artificial demonstraram uma notável capacidade na identificação de sinais precoces de doenças cardíacas, evidenciando áreas de preocupação antes mesmo da manifestação clínica óbvia. Além disso, a aplicação da inteligência artificial permitiu uma personalização mais refinada dos diagnósticos, incorporando fatores genéticos, ambientais e de estilo de vida, ampliando assim a abordagem personalizada na medicina cardiovascular. Considerações Finais: A integração da inteligência artificial na Cardiologia não apenas representa um avanço promissor, mas também oferece possibilidades inovadoras para o diagnóstico precoce e personalizado de doenças cardiovasculares. Estes avanços não se limitam apenas a melhorar a eficácia clínica, mas também têm o potencial de impactar positivamente a gestão e prevenção dessas patologias, contribuindo assim de forma significativa para a promoção da saúde cardiovascular em maior escala.
Urbanisasi dalam Tinjauan Historis: Studi Kasus Pemukiman Kumuh di Kelurahan 3-4 Ulu Kota Palembang, 2010-2020
Authors: Maharani Alda Risma , Wargadalem Farida Ratu , Safitri Sani
Published: May 2024

This article examines the urbanization that occurred in slum settlements in Subdistrict 3-4 Ulu, Palembang City from 2010-2020. The focus of this article is on the ethnic diversity of living in slums and the socioeconomic problems faced as a result of urbanization. The research process starts from searching for data to writing articles using historical methods. This article aims to identify the impact of social exclusion and marginalization on ethnic minority groups as well as environmental damage due to urbanization. The research results show that Subdistrict 3-4 Ulu, Palembang City is classified as a very slum settlement. This can be seen in slum housing locations, lack of infrastructure, high unemployment rates, and limited access to education and health services. The studies that have been carried out contribute to providing useful insights into designing sustainable development policies in the future by proposing various mitigation efforts and solutions, including government measures, housing, and infrastructure improvement programs, as well as the importance of social integration and community participation.
AI-powered Neuroprosthetics for brain-computer interfaces (BCIs)
Authors: Mohan Raja Pulicharla  , Varsha Premani
Published: May 2024

Imagine a world where individuals with lost or impaired sensory or motor function can regain independence and control through technology. This is the promise of neuroprosthetics, a rapidly evolving field that bridges the gap between the nervous system and external devices. Neuroprosthetics encompass a range of implanted or external devices designed to: Substitute for a malfunctioning part of the nervous system. Assist in the recovery or enhancement of lost or impaired function. Augment existing capabilities, creating new possibilities. These devices interact with the nervous system using various methods, including: Electrical stimulation: Directly stimulating nerves or brain tissue to evoke desired responses. Recording brain activity: Capturing electrical signals generated by the brain for further processing and interpretation. Common applications of neuroprosthetics include: Cochlear implants: Restoring hearing in individuals with severe hearing loss. Deep brain stimulation (DBS): Treating movement disorders like Parkinson's disease and essential tremor. Bionic limbs: Providing control of prosthetic arms and legs for individuals with limb loss. Brain-computer interfaces (BCIs): Enabling communication and control of external devices using brain signals alone. Neuroprosthetics offer a glimpse into the future of medicine and technology. With ongoing advancements, these devices have the potential to revolutionize how we treat neurological conditions, restore lost abilities, and even enhance human potential. However, significant challenges remain, including ensuring long-term safety, improving accuracy and reliability, and addressing ethical considerations. As research continues, neuroprosthetics holds immense potential to improve the lives of millions and redefine what it means to be human. The integration of artificial intelligence (AI) with neuroprosthetics has marked a significant milestone in the development of brain-computer interfaces (BCIs). This emerging synergy aims to enhance the quality of life for individuals with disabilities by restoring lost sensory, motor, and cognitive functions. This review article explores the advancements in AI-powered neuroprosthetics for BCIs, focusing on their design, functionality, and the ethical considerations that accompany their integration into medical practice.
Approach to the patient with abnormal liver biochemistry
Authors: Iván Darío Sánchez Arguelles  , Iván Alberto Salas Pinzón  , Evasandrid Romero Jiménez  , Juan Pablo Sánchez Garcés  , Roberto Rodríguez Marí
Published: May 2024

Altered liver function tests are a common finding that requires careful interpretation and thorough correlation with the patient's clinical picture. This paper provides a systematic and practical approach to the management of patients with alterations in their liver biochemistry. The fundamental concepts of liver anatomy and physiology are reviewed, emphasizing the importance of understanding the microscopic organization of the organ and key metabolic processes. The most used liver tests, their interpretation and the patterns of alterations that may occur will be described, and the importance of a detailed anamnesis will be emphasized. Guidelines are provided for the diagnostic approach according to the pattern of alteration observed and the different patterns of transaminase elevation, from mild to moderate and severe, and their possible causes are discussed in detail. The importance of considering fatty liver disease as a frequent cause of mild and persistent transaminase elevations is highlighted, and noninvasive tools for the evaluation of liver fibrosis, such as specialized scores and markers, are mentioned. In summary, this document presents an updated and practical text for the proper interpretation of alterations in liver biochemistry, emphasizing the importance of a close correlation with the clinical context of the patient, which will allow an accurate diagnosis and appropriate management.
The effect of profitability, liquidity, solvency, and company growth on the acceptance of going concern audit opinions on consumer cyclicals companies listed on the IDX in 2019-2022
Authors: Azzky Nurul Andini  , Riska Franita
Published: May 2024

This study was conducted to obtain empirical evidence on the influence of profitability, liquidity, solvency, and company growth on the acceptance of going concern audit opinions on consumer cyclycals companies listed on the Indonesia Stock Exchange (IDX) in 2019-2022. The study was conducted with an associative quantitative approach. The type of data used is secondary data in the form of company financial statements obtained from the official IDX website. There were 64 samples taken by purposive sampling technique. This study used logistic regression analysis techniques. The results showed that the profitability, solvency and growth of the company partially did not affect the acceptance of the going concern audit opinion, while liquidity partially affected the acceptance of the going concern audit opinion and the profitability, liquidity, solvency, and growth of the company simultaneously affected the acceptance of the going concern audit opinion.
A review study on Agni karma and Ksha akarma in the management of Garbha Saya Grivamukhagata Vrana (cervical erosion)
Authors: Ruksana Parvin  , Nazrul Islam Prodhani
Published: May 2024

Purpose: To review the effectiveness of Agni karma and Ksha akarma in the management of Garbha Saya grivamukhagata vrana (Cervical Erosion). Material and Methods: All the research studies from 2002 to 2024 related to concerned topic collected from electronic data base and journals both online and offline. The procured data were studied in details and scientific review was done. Results: On reviewing the previous works it is found that maximum studies were done on Agnikarma by shalaka having vrana shodhana, ropana andprasadana properties. Though Ksharakarma also yielded good results but comparatively fewer studies were found. Discussion: Cervical erosion warrants urgent attention of the gynecologists as it affects the patient’s reproductive health and psychology. Modern treatment for cervical erosion is cauterization and cryosurgery which have many complications such as bleeding per vagina, cervical incompetence, secondary infertility etc. So Agnikarma and Ksharakarma can be better alternative for effective treatment of cervical erosion Conclusion: All the research works mainly were targeted for finding a best Shodhana and Ropana drugs for cervical erosion. All works were carried out on Bahya parimarjana (external application). This facilitates drugs effect for early and uncomplicated wound healing.
The Whining Karen meme on X: a semiotic analysis
Authors: Yanuar Rose Mutiara , Agustina Mia Fitria , Februansyah Rizki
Published: May 2024

This study conducts a semiotic analysis of the specific "Karen" meme of whining on social media platform X, utilizing Ferdinand de Saussure's semiotic theory. This meme typically depicts a stereotype of a forceful, entitled, and confrontational individual, and it is often linked to middle-aged white women, expanded to encompass various individuals. The findings reveal a consistent pattern of meaning play, revolving around the utilization of the term "Karen" in conjunction with the descriptor "whining." "Karen" is used as a stereotypical reference, often employed to mock individuals perceived as entitled, overly critical, or complaining. It is used to dismiss or undermine the credibility of the opposing viewpoint, implying that the concerns expressed are unwarranted or exaggerated. Overall, the pattern across these conversations highlights the use of Karen memes as a means of ridiculing or dismissing opposing viewpoints perceived as complaining or entitled. This use adds a derisive and somewhat sarcastic tone to the responses, suggesting that the concerns are frivolous or exaggerated. This highlights the complex interplay of language, stereotype, and meaning in internet memes. The results underscore the adaptability and depth of Saussure's theory in deciphering the intricacies of online discourse, particularly within the realm of meme culture.
Peningkatan Nilai Ekonomis Madu melalui Pelatihan Pembuatan Fermented Garlic Honey di Panti Asuhan Al-Madina Surabaya
Authors: Wulansari Devyani Diah , Savitri Emma , Kirtishanti Aguslina , Wulandari Devyana Dyah , Susilo Raden Jokokuncoroningrat , Wuryaningsih Lucia Endang
Published: May 2024

Berwirausaha merupakan salah satu upaya yang dapat dilakukan untuk membangkitkan kembali perekonomian Indonesia paska pandemi Covid 19. Untuk  dapat  mengembangkan  usahanya  sendiri  masyarakat  harus  dapat  melakukan kretifitas   yang   dapat   membuat   sesuatu   yang   baru, berbeda   dan   dapat   mengembangkannya. Grha Aitam merupakan panti asuhan berbasis entrepreneur sebagai konsep pemberdayaan  anak yatim dan para dhuafa, berbekal dukungan dari stake holder, khususnya donatur. Salah satu bentuk wirausaha yang ditekuni saat ini berupa pengemasan madu. Hasil dari penggalian informasi dengan mitra, konsumen baru yang ditawarkan madu rata-rata kurang tertarik dengan rasa dan bau madu, serta kurangnya wawasan terkait manfaat madu untuk kesehatan.  Melalui program pengabdian kepada masyarakat, solusi yang ditawarkan oleh tim Pengusul kepada Mitra adalah membuat sebuah inovasi produk madu berupa Fermented Garlic Honey (FGH) yang menawarkan rasa dan bau lebih menarik serta unik, serta klaim manfaat kesehatan yang baik, dengan menggunakan aplikasi teknologi fermentasi sehingga dapat dihasilkan produk berkualitas. Program ini diawali dengan evaluasi proses pengemasan madu dengan meninjau kembali layout sarana yang digunakan, kemudian diberikan pengetahuan terkait proses pembuatan serta manfaat medis FGH. Hal ini didukung dengan pengadaan alat fermentasi hingga pada pengemasan serta pengujian laboratorium untuk menganalisis kualitas FGH yang dihasilkan. Melalui serangkaian pelatihan yang difasilitasi oleh Tim, mitra dapat menghasilkan produk FGH yang aman, berkualitas dan berdaya jual tinggi.
Efektifitas Penggunaan Bahan Ajar Situs Sejarah Lokal Lampung Untuk Meningkatkan Hasil Belajar Mahasiswa
Authors: Lestari Nur Indah , Rachmedita Valensy , Sinaga Risma Margaretha
Published: May 2024

Bahan ajar merupakan salah satu bagian terpenting, Bahan ajar adalah bahan- bahan atau materi pelajaran yang disusun secara lengkap dan sistematis berdasarkan prinsip-prinsip pembelajaran yang digunakan mahasiswa dalam proses pembelajaran. Bahan ajar bersifat sistematis artinya disusun secara urut sehingga memudahkan mahasiswa belajar sebagai salah satu sumber belajar. Namun pada kenyataanya Seiring perkembangan bahan ajar seharusnya tidak  focus pada satu bahan ajar saja, melainkan harus menggunakan bahan ajar lainnya yang relevan dengan tema perkuliahan. Salah satu cara yang dapat dilakukan dengan mengembangkan bahan ajar berbasis situs sejarah local. Penggunaan bahan ajar yang menggunakan sejarah local masih sangat minim, oleh karena itu diperlukan pengembangan bahan ajar terutama berbasis sejarah local yang mampu meningkatkan hasil belajar mahasiswanya, yang dalam hal ini situs sejarah yang ada di Lampung. Metode penelitian ini menggunakan metode eksperimen. Berdasarkan hasil penelitian diperoleh bahwa hasil uji statistic diperoleh hasil signifikan yang diperoleh 0,138>0,05, kemudian terdapat peningkatan hasil belajar siswa yang sebelumnya pada saat pretest dikelas eksperimen diperoleh nilai rata- rata 63 dan hasil posttest 81,25, sedangkan untuk kelas control  hasil pretest di kelas kontrol diperoleh nilai rata-rata 62,25 dan setelah dilakukan kegiatan diperoleh hasil posttest 73,5. Kata kunci: bahan ajar, situs sejarah, hasil belajar
BIOPROTECTION OF POULTRY ENTERPRISES FROM PARASITES AND THE RELEVANCE OF MONITORING THE EPIZOOTIC SITUATION ON EIMERIOSIS IN BROILER CHICKENS
Authors: Tashbulatov A. A. , Safiullin R. T.
Published: May 2024

The article identifies critical points in the bioprotection of poultry enterprises that
determine the epizootic situation on avian parasites by the example of coccidiosis.
Factors were described that were important in the transmission cycle of coccidia
oocysts from infected broiler chickens through contaminated premises for raising
birds, from crawling and flying insects, namely, tenebrionid beetles or flies; and
from equipment and footwear before transfer to susceptible broiler chickens during
the next broiler breeding cycles. The research-based relevance and the need for
monitoring the epizootic situation on Eimeria infections in broiler chickens in
different seasons of the year were outlined to determine their number in different
broiler breeding technologies. The epizootic situation on the Eimeria infection rate
in broiler chickens was studied on poultry farms in Russia over the past 15 years.
The real epizootic situation on eimeriosis of broiler chickens and laying hens was
determined, and the age and seasonal dynamics of infection, and the contamination
of environmental objects with invasive elements were established. Analysis of research
allows us to draw up guidelines to increase bioprotection of poultry enterprises, reduce the transmission risk of coccidia oocyst, increase economic efficiency of
broiler meat production and improve sanitary culture of production and personnel
that serve poultry farms. Coccidiosis monitoring must be continued.
STROBILOCERCOSIS (HYDATIGERA TAENIAEFORMIS S.L.,
LARVAE) IN MOUSE-LIKE RODENTS FROM THE PROTECTED
AREAS OF MORDOVIA
Authors: Kirillova N. Y. , Kirillov A. A.
Published: May 2024

The main intermediate hosts of the cestode Hydatigera taeniaeformis (Batsch, 1786)
sensu lato (s. l.) are mouse-like rodents. During the 2018-2022 field seasons, the
helminth fauna in 2.812 specimens of 14 species of mouse-like rodents was studied
using the method of complete helminthological dissection in two protected areas
of the Republic of Mordovia: the Mordovia State Nature Reserve (1.534 rodents
studied) and Smolny National Park (1.278 rodents). The micromammals were
captured using steel spring traps. Trap lines consisted of 20 steel spring traps located
in 10 m intervals. Strobilocerci Hydatigera taeniaeformis s. l. was only found in 5
rodent species from 14 studied rodents: pygmy wood mouse Sylvaemus uralensis,
yellow-necked mouse Sylvaemus flavicollis, striped field mouse Apodemus agrarius,
bank vole Clethrionomys glareolus, and pine vole Microtus subterraneus. The total H.
taeniaeformis s. l. larvae infection rate in the rodents was 1.2% (34 rodents infected),
and an abundance index was 0.02 specimens (42 larvae collected). Hydatigera
taeniaeformis s. l. larvae were recorded in the Smolny National Park for the first time.
The pine vole M. subterraneus was recorded as the intermediate host for such cestode
species for the first time. Our data enhance the understanding of the strobilocercosis
spread among mouse-like rodents of the Middle Volga Region fauna.
DOGS AS A SOURCE OF PARASITIC CONTAMINATION OF URBAN ENVIRONMENTS
Authors: Panova O. A. , Kurnosova O. P. , Krasnorogkina O. V. , Kuznetsova A. D. , Kuznetsov K. S.
Published: May 2024

The main source of many zoonotic infections is soil contaminated with dog feces.
The urban external environment is a special space the local areas of which (parks,
squares, yard spaces) happen to be significantly polluted by dog excrements,
especially in spring. Feces of infected dogs left in urban areas represent a source
of contamination by causative agents of soil-transmitted parasitic infections. The
purpose of this research was to determine the distribution of parasitic pathogens in dog feces collected in urban areas. We collected and examined 492 samples of
dog feces in Moscow and Zhukovsky for 2022 and 2023. The study was carried out
in spring after the snow melted. The feces were studied by a combined flotation
method with a sodium nitrate solution with density of 1.38. Causative agents of
parasitic diseases were found in 2.6% of the fecal samples. Toxocara canis (1.2%),
Sarcocystis sp. (0.6%), Isospora sp. (0.4%), Toxascaris leonina (0.2%) and Giardia sp.
(0.2%) were found in the dogs. Toxocara and giardia are dangerous to humans. Our
results confirm the data obtained by other researchers that indicate a high Toxocara
infection rate in dogs and a high level of urban soil contamination with T. canis eggs.
PARASITOLOGICAL AND MICROBIOLOGICAL ASSESSMENT OF SOIL ON THE TERRITORY OF MOKVA HORTICULTURAL NON-PROFIT PARTNERSHIP IN KURSK
Authors: Samofalova N. A. , Trutaeva N. N.
Published: May 2024

A parasitological condition of soil intended for growing crops requires special
attention since it can contribute to the distribution of invasive material to humans
and animals through plant crops. The article presents a parasitological and
microbiological assessment of the soil on the territory of Mokva Horticultural NonProfit Partnership. The results of the studies showed that the prevalence of sample
contamination was 20.1%. Eggs of geohelminths of epidemiological importance
were found in the samples. The samples positive for Toxocara canis eggs ranged
from 8.3% in individual plots to 27.5% in adjacent territory. Infected stray animals
were the main sources of Toxocara canis eggs entering the soil of garden plots. The
results of the studies on a parasitological condition of the soil on which vegetable
and berry crops were grown showed its low contamination degree. Cultivated soil
from garden plots was found to be contaminated in 11.4% of cases. Ascaris suum
eggs were observed in the samples. The intensity of soil contamination was 8.3±1.1
specimens/kg. The detected pathogen of this species indicates the use of unsafe,
from a parasitological point of view, farm animal waste to increase soil productivity
and crop yields.
Comparison of Myometrial Invasion Depth Examination Methods in Endometrial Cancer
Authors: Özdemir Savaş , Doğan Ozan , Kinter Alp Koray , Akbayır Özgür , Şahin Fatih
Published: May 2024

Background: Endometrial cancer (EC) is often presents in the postmenopausal period. Among the risk elements are obesity, early menarche, late menopause, unopposed estrogen exposure associated with nulliparity, diabetes, advanced age (>55 years), and tamoxifen use. Endometrial biopsy is the gold standard diagnostic method. The typical surgical process comprises a complete removal of the uterus, a bilateral salpingo-oophorectomy, and cytological examination of peritoneal washing. Invasion of the myometrium (MI) is intricately linked to lymph node metastasis, which is observed in approximately 20% of deep MI cases and in 5% of cases with superficial MI. Therefore, a comprehensive assessment of women with EC, especially those with MI, is important before treatment. The assessment for myometrial invasion (MI) and cervical stromal invasion often involves the use of transvaginal ultrasound (TVUS). The diagnostic accuracy of TVUS varies in reported studies, and some findings are comparable to those obtained through magnetic resonance imaging (MRI). The size of intraoperative tumors and MI is provided to surgeons by frozen section examination, offering crucial information. This study aimed to compare the preoperative TVUS and MRI findings, intraoperative frozen sections, and postoperative final results for 321 patients diagnosed with EC. Methods: Individuals who underwent surgery at the third-stage tertiary gynecologic-oncology clinic for EC were included in the study. The study excluded cases lacking preoperative biopsy, TVUS, and magnetic resonance imaging (MRI), as well as cases featuring obvious extrauterine lesions. Non-endometrioid cases, endometrial hyperplasia, and cases with an identification of organ involvement outside the uterus during surgery were also excluded. The TVUS and MRI findings were compared with the intraoperative frozen sections using McNemar’s test. The concordance of the assessments was determined using the kappa coefficient. The statistical significance level, represented by alpha (α), was set at p < 0.05. Results: The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and kappa values for TVUS were 100%, 94.3%, 21.7%, 100%, and 0.34, respectively. For MRI, these values were 100%, 97.8%, 41.7%, 100%, and 0.579, and for frozen section, they were 100%, 99.7%, 83.3%, 100%, and 0.908, respectively. Conclusions: In addition to the gold standard frozen section, TVUS and MRI played an important preoperative role in determining the depth of invasion. While MRI is expensive, TVUS stands out for its practical nature and easy accessibility. In the preoperative examination, TVUS provided acceptable results in guiding intraoperative decisions for lymphadenectomy, with similar sensitivity to MRI and frozen sections.
177Lu-FA-DOTA-PEG-PLGA Nanoparticles Show Antitumor Efficiency in Targeting Ovarian Cancer
Authors: Guo Ziming , Du Yi , Zhao Jun , Sha Sha , Wang Jian
Published: May 2024

Background: The development of novel therapies holds significance in improving the prognosis of ovarian cancer (OC). This study aimed to prepare 177Lu-FA-DOTA-PEG-PLGA nanoparticles and evaluate their antitumor efficacy in OC. Methods: To obtain nanoparticles with both targeting and degradable properties, we employed folate receptor (FR) as the targeting molecule, the biodegradable material polyethyleneglycol-polylactic acid-co-glycolic acid (PEG-PLGA) as the carrier matrix, and diethylene triamine pentaacetic acid (DOTA) as the metal chelating agent to prepare 177Lu-FA-DOTA-PEG-PLGA nanoparticles. The labeling yield and radiochemical purity were determined. Healthy Institute of Cancer Research (ICR) mice and Bagg albino strain C (BALB/c) nude mice bearing subcutaneously transplanted SKOV3 human OC tumors were given 18.5 Mbq of 177Lu-FA-DOTA-PEG-PLGA nanoparticles for histological distribution analysis and micro-single-photon emission computed tomography/computed tomography (micro-SPECT/CT) imaging, respectively. Twelve BALB/c nude mice bearing subcutaneously transplanted tumors or 12 BALB/c nude mice bearing intraperitoneal metastatic tumors were assigned to control (received 0.1 mL saline solution), chemotherapy (received twice 3 mg/kg cisplatin per week), and nanoparticle groups (received 18.5 Mbq nanoparticles via tail vein or intraperitoneal injection) (n = 4 per group). Tumor growth inhibition (TGI) and ascitic fluid volume were calculated to investigate antitumor efficiency. Hematoxylin and eosin (HE) staining was performed to evaluate the safety of nanoparticles. Results: The 177Lu-FA-DOTA-PEG-PLGA nanoparticles (labeling yield: 97–98%; radiochemical purity: 96–98%) exhibited a long blood circulation time and a low renal radioactivity uptake (1.646 %ID/g). Micro-SPECT/CT imaging revealed the highest tumor-to-muscle uptake ratio of 2.81 at 24 h. After tail vein injection of nanoparticles, the tumor growth in the chemotherapy and nanoparticle groups was inhibited compared with the control group. Upon intraperitoneal injection, fluorescence intensities of intraperitoneal metastatic tumors in the control, chemotherapy and nanoparticle groups showed a statistical difference (F = 6.09, p = 0.029). Ascitic fluid volumes in the chemotherapy and nanoparticle groups were significantly lower than that in the control group (F = 13.43, p = 0.006). HE staining results showed no obvious abnormalities in the small intestine and colon tissues of the mice in the nanoparticle group compared to the control group. Conclusions: We successfully developed 177Lu-FA-DOTA-PEG-PLGA nanoparticles with a long blood circulation time and low renal radioactivity uptake. These nanoparticles could inhibit OC tumor growth and intraperitoneal metastasis, suggesting a potential novel therapy for OC patients.