bluuebunny/crossref_metadata_2025 huggingface dataset:
Polymorphism of the rs1815739 locus of the «speed gene» ACTN3 in Siberian populations
Authors: Б.А. Малярчук, , М.В. Деренко, , Г.А. Денисова, , А.Н. Литвинов,
Published: January 2023

Потеря активности гена ACTN3 из-за стоп-кодона в локусе rs1815739 (аллель rs1815739-T или 577X) приводит к отсутствию α-актинина-3 в быстросокращающихся мышечных волокнах, что способствует повышению выносливости и устойчивости к холоду. Эти обстоятельства стали основой для гипотезы о том, что повышение частоты аллеля rs1815739-T в популяциях Евразии и Америки в сравнении с Африкой произошло под действием отбора еще на начальных этапах освоения планеты человеком. В настоящей работе нами проанализирован полиморфизм локуса rs1815739 в популяциях Сибири - на юге (буряты, алтайцы, тувинцы, тоджинцы) и на севере (чукчи, коряки, эвены, эвенки) региона. Показано, что, вопреки вышеупомянутой гипотезе, частота аллеля rs1815739-T выше на юге Сибири, а к северу, наоборот, повышается частота аллеля rs1815739-C и генотипа CC. Результаты исследования позволяют предположить, что характер распространения вариантов полиморфизма локуса rs1815739 гена ACTN3 в сибирских популяциях не связан с адаптацией к холоду.

Loss of ACTN3 gene activity due to a stop codon at the rs1815739 locus (rs1815739-T or 577X allele) leads to the absence of α-actinin-3 in fast-twitch muscle fibers, which contributes to increased endurance and resistance to cold. These circumstances became the basis for the hypothesis that the increase in the frequency of the rs1815739-T allele in the populations of Eurasia and America, in comparison with Africa, occurred under the influence of selection at the initial stages of human exploration of the planet. In this work, we analyzed the polymorphism of the rs1815739 locus in the populations of Siberia - in the south (Buryats, Altaians, Tuvinians, Todjins) and north (Chukchi, Koryaks, Evens, Evenks) of the region. We have shown that, contrary to the above hypothesis, the frequency of the rs1815739-T allele is higher in the south of Siberia, while in the northern direction, on the contrary, the frequency of the rs1815739-C allele and the CC genotype increases. The results of the study suggest that the distribution pattern of the rs1815739 polymorphic variants in Siberian populations is not associated with adaptation to cold.
Permian genetic component in the gene pool of the indigenous peoples of the Volga region
Authors: В.Н. Харьков, , Л.В. Валихова, , А.А. Зарубин, , С.С. Литвинов, , Н.В. Екомасова, , Э.К. Хуснутдинова, , В.А. Степанов,
Published: January 2023

Выявлен вклад пермского по происхождению компонента в генофонд различных этносов Поволжья, который присутствует у народов пермской языковой группы и тюркоязычных этносов. Он полностью доминирует у удмуртов и бесермян, а также занимает пятую часть генофонда коми. Анализ распределения этого компонента в популяциях и состава их генофондов по различным сублиниям гаплогрупп Y-хромосомы показывает, что современные удмурты сохранили свой исходный состав генофонда и не подвергались смешению с пришедшими позднее угорскими, тюркскими и славянскими переселенцами. Внесение этого генетического компонента в состав татар и башкир было связано с ассимиляцией местного пермского населения. Распределение в популяциях частот пермского компонента по геномным данным и частот гаплогрупп N1a1a и N1a2b в популяциях удмуртов, бесермян и коми полностью совпадает с данными антропологии и лингвистики.

The contribution of the Permian by origin component to the gene pool of various ethnic groups of the Volga region, which is present among the peoples of the Permian language group and Turkic-speaking ethnic groups, is revealed. It completely dominates on Udmurts and Besermyans, and also occupies a fifth of the Komi gene pool. An analysis of the distribution of this component in populations and the composition of their gene pools for various sublines of the Y-chromosome haplogroups shows that modern Udmurts retained their original composition of the gene pool and were not subjected to mixing with the Ugric, Turkic and Slavic settlers who came later. The introduction of this genetic component into the composition of the Tatars and Bashkirs was associated with the assimilation of the local Permian population. The distribution of frequencies of the Permian component in populations according to genomic data and the frequencies of haplogroups N1a1a and N1a2b in the populations of the Udmurts, Besermians and Komi completely coincides with the data of anthropology and linguistics.
Prediction Model for COVID-19 Patient Visits in the Ambulatory Setting
Authors:   Institute for Research on Equity and Community Health (iREACH), ChristianaCare Health Services, USA, RC Li , CK Harrison ,   Connecticut Children’s and UConn School of Medicine, USA, CT Jurkovitz ,   Institute for Research on Equity and Community Health (iREACH), ChristianaCare Health Services, USA, K Ndura ,   Institute for Research on Equity and Community Health (iREACH), ChristianaCare Health Services, USA, MA Papas ,   Institute for Research on Equity and Community Health (iREACH), ChristianaCare Health Services, USA, RK Kerzner ,   Medical Group, ChristianaCare Health Services, USA, C Teal ,   Family and Community Medicine, ChristianaCare Health Services, USA, T Chiam ,   Infection Prevention & Control, Children’s Hospital of Philadelphia, USA
Published: January 2023

Objective: Healthcare systems globally were shocked by coronavirus disease 2019 (COVID-19). Policies put in place to curb the tide of the pandemic resulted in a decrease of patient volumes throughout the ambulatory system. The future implications of COVID-19 in healthcare are still unknown, specifically the continued impact on the ambulatory landscape. The primary objective of this study is to accurately forecast the number of COVID-19 and non-COVID-19 weekly visits in primary care practices. Materials and Methods: This retrospective study was conducted in a single health system in Delaware. All patients’ records were abstracted from our electronic health records system (EHR) from January 1, 2019 to July 25, 2020. Patient demographics and comorbidities were compared using t-tests, Chi square, and Mann Whitney U analyses as appropriate. ARIMA time series models were developed to provide an 8-week future forecast for two ambulatory practices (AmbP) and compare it to a naïve moving average approach. Results: Among the 271,530 patients considered during this study period, 4,195 patients (1.5%) were identified as COVID-19 patients. The best fitting ARIMA models for the two AmbP are as follows: AmbP1 COVID-19+ ARIMAX(4,0,1), AmbP1 nonCOVID-19 ARIMA(2,0,1), AmbP2 COVID-19+ ARIMAX(1,1,1), and AmbP2 nonCOVID-19 ARIMA(1,0,0). Discussion and Conclusion: Accurately predicting future patient volumes in the ambulatory setting is essential for resource planning and developing safety guidelines. Our findings show that a time series model that accounts for the number of positive COVID-19 patients delivers better performance than a moving average approach for predicting weekly ambulatory patient volumes in a short-term period.
The Chronic Effects of a Quantified Jump-Landing Program on Bone Health, Body Composition and Performance Parameters in Premenopausal Women
Authors:   Toi Ohomai Institute of Technology, Department of Sport and Fitness, Faculty of Health, Education and Environment, Tauranga, New Zealand, TL Clissold , JB Cronin ,   AUT University, Sports Performance Research Institute New Zealand (SPRINZ), AUT University, Auckland, New Zealand, MJ De Souza ,   Department of Kinesiology, Pennsylvania State University, Pennsylvania, USA, PW Winwood ,   Toi Ohomai Institute of Technology, Department of Sport and Fitness, Faculty of Health, Education and Environment, Tauranga, New Zealand
Published: January 2023

The primary purpose of this study was to determine the effects of a 12-month quantified jump-landing program at clinically relevant bone sites in premenopausal women. Secondary measures of interest included; lower body explosive power, muscle reactivity, balance performance parameters and body composition. A longitudinal controlled trial was implemented to determine the effect of utilizing previously quantified jumps and hops with specific cues provided for jump-landings. Participants; Fifty-seven women (age, 42.4 ± 5.50 y; body mass, 70.2 ± 11.5 kg; height, 165.4 ± 0.10 cm; body fat, 31.5 ± 6.20%) were assigned to a jump (JL) or control (CON) group. The JL performed periodized jumping-landing exercises up to five times per week for 12-months. Linear mixed model regression analysis was used to determine if differences existed between the JL and CON. Significant group main effects (P<0.01) in favour of the JL (↑0.41 - ↑3.72%) were observed for bone mineral density and bone mineral content at the femoral neck, total hip and lumbar spine. Significant group main effects (P<0.01) for cross-sectional area, cortical thickness and section modulus at the femoral narrow neck were also in favour of the JL (↑2.78 - ↑3.84%). For ground contact time, improvements in the JL over the CON between baseline and 12-months were apparent (↑21.9% vs. ↓8.86%) with significant group and time effects (P<0.01) being observed. A longitudinal quantified periodized jumplanding program performed 2-3 mins/day; 4-5 times a week is osteogenically effective in improving bone strength at clinically relevant lower body sites associated with osteoporosis in premenopausal women.
Prevalence of Prediabetes and Type 2 Diabetes Mellitus in Patients with Increased Risk for T2D in Tijuana, Mexico
Authors:   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, JE Delgado-Luna , JF Gonzalez-Acosta ,   Department of Family Medicine, General Hospital Zone #8, IMSS, Baja California, Mexico, CA Alvarez- Franco ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, MA Gomez-Rodriguez ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, LA Orduño-Cabrera ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico, MF Ramonetti-Armenta ,   Department of Family Medicine, Family Medicine Unit #27, IMSS, Baja California, Mexico
Published: January 2023

Background: Diabetes Mellitus is a highly prevalent chronic disease, affecting 8.8% of people worldwide. There are many factors related to the development of DM, the most important are modifiable related to lifestyle such as body weight, physical inactivity, smoking and consumption of alcohol. Objective: To know the prevalence of Prediabetes and Type 2 Diabetes Mellitus in patients with increased risk for T2D. Methods: A descriptive cross-sectional study was carried out in the family medicine unit 27, in patients with increased risk for T2D according to the FINDRISC test. The participants were recruited from a previous study titled “Risk assessment for Type 2 Diabetes Mellitus in adults from FMU 27”. The patients with increased risk for T2D were evaluated with paraclinical studies in order to confirm alterations in blood glucose. Descriptive statistics were used, the qualitative variables were expressed in frequencies and percentages, and the quantitative variables in measures of central tendency and dispersion, the information obtained was analyzed in the statistical program SPSS version 25. Results: 254 patient files were analyzed, selecting 139 patients for the study. Of all the participants with a score greater than 7 in the FINDRISC test, 24.01% were diagnosed with prediabetes and 30.70% with type 2 diabetes mellitus. Conclusions: The prevalence of Diabetes and prediabetes was higher in our population at a short follow-up.
Knowledge, Attitudes and Practices towards Human Papillomavirus (HPV) Vaccine & Prevention of Cervical Cancer among Women Attending Primary Health Care
Authors:   Academy of Family Medicine, Joint Program of Family Medicine, Al-Madinah, Saudi Arabia (KSA), A Aloufi N , R Albelowi ,   Consultant Family Medicine, Joint Program of Family Medicine, Al-Madinah, Saudi Arabia (KSA)
Published: January 2023

Background: Cervical cancer is projected to affect 528,000 people worldwide each year. It is the third leading cause of mortality from cancer in developing nations. HPV vaccination was first introduced in 2006, targeting females between the ages of 9-14 years with the aim of preventing HPV that cause cervical precancerous lesions and cancer. Methods: A cross-sectional descriptive study Among Females Attending Primary Health care in AL-Madina AL-Munawarah. All females attending primary health care centers aged 21-65 years or Al-Madina Al-Munawarah. Sample size was 375. The sample size calculated By using Epi-Info version 3.5.1. The study was started after the approval comes from the research committee at Al-Madina region. The researcher took a consent form from the program director of joint program of family medicine and taken it to MOH in Al-Madina City. One primary healthcare center was chosen from each sector. Results: In this study 400 questionnaires were distributed in which 345 participants and response rate was 86.25%, all of them were female and ranged in age from 14 to 65 years. The majority of participants, 112 (32.5%), were between the ages of 26 and 35 years. The majority of participants 222 (64%) were married, Inquiring as to whether you've heard that HPV can cause cervical cancer. 253 respondents said that they had not heard of it. 17% were unaware that HPV is a virus that is transmitted by sexual contact. 7.8% feel it is widespread in Saudi Arabia. 11.9% believe that both men and women are susceptible to infection. 22% that risky sex can raise one's risk of contracting HPV. The majority of individuals expressed concern about the vaccination's negative effects. 250 out of 388 respondents expressed concern about the immunizations' negative effects. Concerning vaccination decisions, 196 believe they should be decided by the individual concerned, while 92 believe they should be made jointly by parents and the individual. Conclusion: Funding for volunteer groups/non-governmental organizations working in the health sector to raise awareness about cervical cancer among healthcare practitioners and the general public might contribute to further reduce the disease's incidence. Public health education is urgently required on the safety and effectiveness of HPV vaccination.
Mitochondrial Superoxide is the Key for Promoting Cell Migration in Wound Healing
Authors:   Department of Plastic Surgery, Zhejiang Hospital, Hangzhou, 310013, Zhejiang, China, Weidong Ping , Xin Wang ,   Department of Plastic Surgery, Zhejiang Hospital, Hangzhou, 310013, Zhejiang, China, Xiaowei Wang ,   Department of Plastic Surgery, Zhejiang Hospital, Hangzhou, 310013, Zhejiang, China, Fei Li ,   Department of Plastic Surgery, Zhejiang Hospital, Hangzhou, 310013, Zhejiang, China, Chunyan Huang ,   Department of Plastic Surgery, Zhejiang Hospital, Hangzhou, 310013, Zhejiang, China, Qiming Zhao ,   Department of Plastic Surgery, Zhejiang Hospital, Hangzhou, 310013, Zhejiang, China
Published: January 2023

Introduction: The focus of current study was to investigate the role of mitochondrial superoxide for promoting cell migration in healing responses. Methods: To simulate the skin wound healing process, scratch wound assay in A549 cells was utilized. Subsequently, mitochondrial superoxide and intracellular calcium flux (Ca2+) were measured by MitoSox red reagent and Fluo-4 staining. Paraquat (PQ), N-acetyl cysteine (NAC), superoxide dismutase (SOD) mimics (EUK-134), free radical scavenge (MCI-186), and diphenyliodonium (DPI) were added into medium to evaluate the influences of reactive oxygen species (ROS) and superoxide on cell migration. Results: Compared with before wound (BW), mitochondrial superoxide increased time-dependent manner. Correspondingly, Ca2+ transients was rapidly elevated after scratch wound and gradually declined toward an steady level, as evidenced by Fluo-4 fluorescence intensity. Scratch wound assay displayed that cell migration in PQ 0.1 mM group was stronger than that of Control group, whilst it was restrained after administration of 10 mM NAC. Additionally, cell migration in EUK-134 and MCI-186 group was conspicuously lower than that of Control group and similar with the degree of inhibiting role of DPI, indicating that mitochondrial superoxide served the crux influence on promoting cell migration after scratch. Conclusion: ROS and superoxide production during scratch wound facilitated cell migration. Importantly, mitochondrial superoxide played the positive effects on healing response.
Analytical Approaches to Wound Healing Process
Authors:   Department of Basic Sciences, Faculty of Pharmacy, Final International University, Cyprus, M Pournaki , SAH Kia ,   Department of Clinical Pharmacy, Faculty of Pharmacy, Final International University, Cyprus, S Tetik ,   Department of Medical Biochemistry, Faculty of Pharmacy, Final International University, Cyprus
Published: January 2023

Wound healing is a complex domain that needs to solve abundant parameters. Changed protein concentration, pH effect on wound environment, mediators of immune system, and aging process are fight subjects of wound healing. Therefore, in modern approaches to improve of challenges are tending to analytical techniques for lighting dark side. Research of genetic markers, micro RNAs expression or post-translational modifications of proteins was recently evaluated in wound healing. In review article, we focused on some parameters of the healing system which are affected processes of wound healing and some analytical approaches which are using to find connect of the network.
Unraveling the reaction mechanisms for furfural electroreduction on copper
Authors: Liu Sihang , Mukadam Zamaan , Scott Soren , Sarma Saurav , Titirici Maria-Magdalena , Chan Karen , Govindarajan Nitish , Stephens Ifan , Kastlunger Georg
Published: January 2023

Electrochemical routes for the valorization of biomass-derived feedstock molecules offer sustainable pathways to produce chemicals and fuels. However, the underlying reaction mechanisms for their electrochemical conversion remain elusive. In particular, the exact role of proton-electron coupled transfer and electrocatalytic hydrogenation in the reaction mechanisms for biomass electroreduction are disputed. In this work, we study the reaction mechanism underlying the electroreduction of furfural, an important biomass-derived platform chemical, combining grand-canonical (constant-potential) density functional theory -based microkinetic simulations and pH dependent experiments on Cu under acidic conditions. Our simulations indicate the second PCET step in the reaction pathway to be the rate- and selectivity-determining for the production of the two main products of furfural electroreduction on Cu, furfuryl alcohol and 2-methyl furan, at moderate overpotentials. We further identify the source of Cu’s ability to produce both products with comparable activity in their nearly equal activation energies. Furthermore, our microkinetic simulations suggest that surface hydrogenation steps play a minor role in determining the overall activity of furfural electroreduction compared to PCET steps due to the low steady-state hydrogen coverage predicted under reaction conditions, the high activation barriers for surface hydrogenation and the observed pH dependence of the reaction.
Quantitative Analysis of Diubiquitin Isomers Using Ion Mobility-Mass Spectrometry
Authors: Shestoperova Elizaveta I. , Ivanov Daniil G. , Strieter Eric R.
Published: January 2023

The diversity of ubiquitin modifications calls for methods to better characterize ubiquitin chain linkage, length, and morphology. Here, we use multiple linear regression analysis coupled with ion mobility mass spectrometry (IM-MS) to quantify the relative abundance of different ubiquitin dimer isomers. We demonstrate the utility and robustness of this approach by quantifying the relative abundance of different ubiquitin dimers in complex mixtures and comparing the results to the standard, bottom-up ubiquitin AQUA method. Our results provide a foundation for using multiple linear regression analysis and IM-MS to characterize more complex ubiquitin chain architectures.
MAGNETORECEPTION IN FRUIT FLIES, BEES AND ANTS
Authors: Mandal Fatik Baran , Chakroborty Bikash
Published: January 2023

Few insects have the sensory ability to sense and use the earth’s magnetic field. Studies have revealed a wealth of information on the magnetic sense of some insects. However, the mechanism of sensing the earth’s magnetic field, called magnetoreception, is still enigmatic in insects. Magnetoreception studies in fruit flies, bees, and ants are well-documented. Of two hypothesized types of magnetoreception mechanisms in those insects, one is ferromagnetic, and the other is light-dependent. Although experimental results appear to be consistent with the proposed hypothesized mechanisms it is possible that there is still an unknown mechanism that would explain and confirm the experimental results. Thus, theories explaining magnetoreception in insects are yet to be come out. Magnetoreception plays a role in migration, orientation, as well as navigation in insects. Several sensory cues play significant role in migration. Moreover, our understanding of magnetoreception requires information from various branches of science, such as physics, behavioural biology, zoology, and environmental biology. The article attempts to update the account of magnetoreception in the said insects as well as to identify the gaps in our knowledge thereof.
A REVIEW OF GROUP B STREPTOCOCCUS (GBS) VAGINAL COLONIZATION AND ASCENDING INTRAUTERINE INFECTION: INTERACTION BETWEEN HOST IMMUNE RESPONSES AND GBS VIRULENCE FACTORS
Authors: H. Wahid Hanan , Mustapha Rounal Puteri F. D. , Bahez Ayesha , Mustafa Mahmud Mohammed I. A. , Kamarudin Norhidayah , Selvakumaran Arvind R. , Ahmad Mustafa Ahmad M. , Ismail Hamizah
Published: January 2023

Vaginal colonization with Group B streptococcus (GBS) or Streptococcus agalactiae can potentially cause ascending intrauterine infection among pregnant women, and hence it is known as one of the risk factors for preterm delivery. Ascending intrauterine infection may also cause the transmission of GBS to the fetus in utero and the newborn during delivery, leading to the development of early onset of neonatal infection. GBS are β-hemolytic, gram-positive bacteria that are opportunistic commensal of the gastrointestinal and urogenital tract of approximately 18% of pregnant women globally. Intrapartum antibiotic prophylaxis (IAP) only reduces the rate of early onset neonatal infection, but not the late onset neonatal infection. Thus, the development of GBS vaccine is thought to be important to decrease the rate of preterm delivery and neonatal infections particularly in low-and-middle income countries where IAP program is not feasible. Vaccination can also be cost-effective for the healthcare system when executed together with IAP program. The aim of the current review is to summarize the mechanisms on how the GBS virulence factors interact with host immune components in the gestational tissues, leading to cervicovaginal colonization and ascending intrauterine infection. The elucidation of these mechanisms is essential for expediting the development of vaccines and novel therapeutic measures targeting these GBS virulence factors that will hamper the vaginal colonization, ascending intrauterine infection and conceptus tissue invasion by GBS. These strategies are crucial to potentially reduce the rate of preterm delivery and subsequent serious complications in the newborn.
THE REMOVAL OF METHYLENE BLUE DYE FROM AQUEOUS SOLUTION THROUGH BIO-ADSORBENTS (EGGSHELL, DATE PALM SEEDS AND PAPAYA SEEDS)
Authors: Baloch Mariya Kiran , Brohi Rafi-u-Zaman , Brohi Khan Muhammad , Ali Baloch Shafquat , Mahar Amanullah , Kiran Madeeha
Published: January 2023

Water pollution is serious concern due to large quantity of colored wastewater discharged from various industrial outlets i.e. textile, and no proper treatment methods are being used to decolor such wastewater. Untreated liquid effluents are discharged in marine ecosystems i.e. lakes, ponds, posing a very serious risk to aquatic life, flora and fauna. It reduces the ability of light penetration to reach deep down in water resulting in a decrement of biological oxygen demand in water bodies. Therefore, the treatment of colored wastewater is significant before discharge. The conventional treatment options are costly and time consuming. The textile dyes can be removed through adsorption using cost effective and eco-friendly adsorbents. This work was aimed to test the potential of Bio-adsorbent waste like eggshells, date palm seeds, and papaya seeds¬¬ to remove methylene blue dye and their effects on following parameters such as dosage mg/g, pH, initial concentration, contact time and speed rpm. The characterization of surface adsorbents was assessed by Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy and Energy Dispersive Spectroscopy. Various isotherms included like fitted Langmuir Freundlich and Kinetic model for the adsorption data. The kinetic study of Methylene blue dye on Adsorbents Eggshell, Date palm seeds and Papaya seeds follow pseudo-second order reaction. Lastly the desorption of Methylene blue dye on Eggshell, Date palm seeds and Papaya seeds using 0.1M HCL. The restoration % of dye on each adsorbent was different found. It can be accepted that adsorbent material as a useful eco–friendly for the removal of MB.
POLLUTION EVALUATION AND HEALTH RISK ASSESSMENT OF HEAVY METALS IN STREAM WATER AT EAST AKIM MUNICIPAL ASSEMBLY, GHANA
Authors: Amankwah Afua Amponsah , Baah Douglas Siaw , Acheampong Eric Boateng
Published: January 2023

Water contamination with toxic chemicals such as heavy metals continue to rise globally and particularly in developing countries due to mining, urbanization, and industrialization. In this study, a total of 10 stream water samples were collected from the mining environment. Physicochemical parameters such as pH and heavy metals; arsenic (As), chromium (Cr), nickel (Ni), and lead (Pb) were examined using standard procedures. The study assessed heavy metals concentrations, evaluated the pollution indices, and the health risk (carcinogenic and non-carcinogenic) for the populace (both adult and child) through direct oral intake and dermal contact of stream water in East Akim Municipal Assembly. The results of the concentrations of As (0.114 mg/kg), Cr (0.00000605 mg/kg), Ni (0.025 mg/kg), and Pb (0.257 mg/kg) revealed that they were within acceptable limits prescribed by World Health Organization (WHO) and Water guidelines. Heavy metal evaluation index (HEI) and degree of contamination (Cd) values obtained indicated that all the examined samples were categorized as low (Cd < 1 and HEI < 10). Non-carcinogenic risk indicated that stream water consumption via ingestion and dermal pathways were below the oral reference dose for their respective heavy metals indicating that both age groups may be ingesting safe levels of heavy metals. Furthermore, the non-carcinogenic risk assessment suggest that children are more susceptible to health threats than adults considering both exposure pathways. Also, the hazard quotient and hazard index were < 1 inferring that there is a tolerable degree of non-carcinogenic health risk for both adults and children in the research area. In addition, average values (1.86×10-5 and 7.12×10-5 for adults and children) obtained for the assessment of cancer risk (CR) for CRingestion were within the safe range of 1×10-6 to 1×10-4 while CRdermal contact average values (4.52×10-8 and 2.53×10-7 for adults and children) were above the range recommended by US Environmental Protection Agency. Regardless of the relatively safe indices recorded, precautionary measures are necessary to sustain the aquatic ecosystem and its quality. Efforts must be made to ensure that heavy metals that can pose health risks even in their low concentrations are monitored and kept as low as possible to ensure safety and reduced human health risks.
Analysis of the Heart Rate of Students with Different Respiratory Rates
Authors:   Ryazan State Agrotechnological University, Emelianova A. S. , Simonyan L. A. ,   State Social and Humanitarian University, Stepura E. E. ,   State Social and Humanitarian University
Published: January 2023

The article deals with the analysis of the initial vegetative status of students with different levels of physical activity and frequency of respiratory movements. The functional reserves of the body are subject to increased requirements not only for training activities, but also for the training load. In this regard, the purpose of this work is to analyze the heart rate variability in students, taking into account the level of physical activity and the frequency of respiratory movements. Registration and analysis of HRV was carried out using a modern complex electrophysiological laboratory “CONAN-4.5”. Mathematical processing of the ECG makes it possible to obtain a number of temporal, spectral and geometric indicators, thanks to which an objective assessment of the state of the autonomic nervous system, including its sympathetic and parasympathetic divisions, is carried out. This method allows you to explore and evaluate the mechanisms of regulation of the cardiovascular system, as well as the tension of regulatory systems. Statistical processing of the material was carried out using Statistica 10.0. Cardiac activity of students was assessed. The gradation of the numerical values of the tension index of the body's regulatory systems was proposed by Shiryaev O. Yu. and Ivleva E. I., who took into account that with severe stress and diseases, the tension index can increase to higher values. As a result, it was proposed to distinguish five types of IN: vagotonic, normotonic, sympathicotonic, suprasymaticotonic, and transboundary. The latter is characterized by an increase in the prevalence of the sympathetic nervous system in the range of more than 600 c.u. During the mathematical processing of the electrocardiogram, numerical values of the stress index were obtained. It was revealed that among the entire studied array of students (when differentiating the IWT calculated according to IN) «normotics» are characterized by an optimal ratio between the parasympathetic and sympathetic divisions of the ANS. When analyzing the electrocardiogram, the values of heart rate were obtained and a relationship was established with the stress index and the type of change or absence of rhythm disturbance in students with different vegetative status. The work established the relationship between the initial vegetative status and the frequency of respiratory movements in students with different vegetative status. Students were offered a test to determine the coefficient of physical activity. The coefficient of physical activity is the ratio of the average daily energy expenditure of a person to the energy expenditure at rest, to the so-called basal metabolic rate. We established the relationship between the stress index and the coefficient of physical activity in students with different vegetative status.
The structure of non-psychotic mental disorders, alexithymia and anxiety in patients with aseptic necrosis of the femoral head
Authors: Ogorenko V.V. , Shornikov A.V. , Zavalko Yu.М.
Published: January 2023

Aseptic necrosis of the femoral head (ANFH) is a severe chronic poliaethiologic disease of the hip joint which is prevalent mainly in young people with a loss of professional and social skills. It is known that the non-psychotic mental disorders appearance in patients with ANFH can lead to the increasing disability, the decreasing in the quality of life, and difficulties in organizing the rehabilitation period. Current researches prove that the preoperative mental state assessment in patients can lead to the statistically significant decrease of the pain intensity in the postoperative period, an improvement in the quality of life related to health, a decrease in anxiety, depression and behavioural problems in the postoperative period. The aim of this research was to study the syndromic features of non-psychotic mental disorders, alexithymia and anxiety levels in patients with ANFH at the preoperative stage. The study involved 137 people aged 25 to 75 years, who were diagnosed with ANFH and identified non-psychotic mental disorders. Clinical-psychopathological and psychodiagnostic methods of examination were used (AUDIT test, Toronto alexithymia scale-20, Taylor manifest anxiety scale). The patients were divided into two groups depending on the ANFH duration. The results of the study revealed the main leading syndromes: asthenic-depressive – in 35.8%, depressive-hypochondriac – in 18.2%, anxious-phobic – in 16.1%, anxious-depressive - in 15.3% and astheno-apathetic – in 14.6% of cases. The average anxiety score was 26 (19; 37), which indicates the presence of a medium-high level of anxiety in the examined, while 52.5 percent of patients had high and very high levels of anxiety. A multivariate logistic regression analysis was performed and as a result, the duration of the disease (OR: 2.23; 95% [CI]: 1.11-4.47; p<0.05), estimates of alexithymia (OR: 2.52; 95% [CI]: 1.00-6.36; p<0.05) and female sex (OR: 2.16; 95% [CI]: 1.03-4.50; p<0.05) were found to be independent risk factors associated with the level of anxiety in persons with ANFH at the preoperative stage.
The levels of hypoxia- and angiogenesis-related regulators and matrix metalloproteinase 9 activity in tear fluid of patients with non-penetrating ocular traumas
Authors: Gavrylyak I.V. , Greben N.K. , Bilous V.L. , Korsa V.V. , Zhaboiedov D.G. , Ağca C.A. , Tykhomyrov A.O.
Published: January 2023

This article was focused on the evaluation of protein biomarkers related to thrombosis, hypoxia, angiogenesis, and tissue remodeling in tear fluid of patients with non-penetrating corneal trauma. 32 patients with non-penetrating corneal injures were enrolled in the study, the control group consisted of 15 healthy patients. Samples of tear fluid were collected from the patients and control volunteers with the use of a disposable end micropipette. Protein levels of D-dimer, hypoxia-inducible factor 1α (HIF-1α), angiostatins, and matrix metalloproteinase 9 (MMP-9) in tear fluids were determined by western blot analysis. Proteolytic activity values of MMP-9 were measured by gelatin zymography. Results of western blot and zymography assay were calculated by densitometry analysis and expressed as arbitrary units. Significant increase of D-dimer and HIF-1α levels in tear fluid of patients with injured cornea by 7.3 (p<0.05) and 56 (p<0.001) folds, respectively was shown, compared with control, indicating thrombotic events and hypoxia condition to be involved in pathogenesis of ocular trauma. Dramatically elevated levels/activity of MMP-9 enzyme (by 105 folds vs. control, p<0.001) suggests intense tissue remodeling and degradation of extracellular matrix in the damaged cornea. Up-regulation of angiostatin level, products of proteolytical cleavage of plasminogen, in tear fluid collected from patients with traumatic eye in comparison with healthy volunteers (by 7.3 folds, p<0.05), could represent an adaptive mechanism, which counteracts excessive hypoxia-induced neovascularization of injured cornea. It is summarized that there was a strong association between elevation of D-dimer, HIF-1α, angiostatins, and MMP-9 levels suggesting thrombosis- and hypoxia-mediated mechanisms triggering wound healing of injured cornea. The findings of this study are novel and provide a basis for further investigations of the reparation mechanisms during non-penetrating ocular trauma. Studied proteins of tear fluid can serve as relevant biomarkers of corneal wound healing and are appropriate for diagnostic and prognostic purposes.
Implementation of the principles of the scientific concept “Medicine of borderline states” regarding donosological diagnosis and overcoming the risks of health deterioration in student youth
Authors: Korobchanskyi V.O. , Sarkis-Ivanova V.V. , Bohachova O.S. , Oliinyk Y.O. , Biеleсka S.V.
Published: January 2023

Today, the methodological basis of disease pre­vention among various categories of the population, including students, is an innovative area of medical science and health care practice, namely medicine of borderline conditions. The development of a system of prenosological diagnosis of pathological conditions in young students and their hygienic correction for disease prevention are important both from a scientific and practical point of view. The study was conducted in the conditions of a natural experiment on the basis of three types of educational institutions, at the place of study of representatives of both sexes aged 14 to 23 years, adolescents and yound adults. In order to achieve the relevant objectives, the study used the following methods: analytic addressed at the study of educational programs, curricula, schedules, profile and regulatory documents; sanitary-hygienic; psychophysiological; psychological, statistic. Set of risk factors related to the educational process among young people studying in three types of educational institutions – secondary educational institutions, higher educational institution, Professional Agrarian Lyceum was analyzed. It is established that unfavorable living conditions affect donosological mental states of asthenic, hypochondriac and depressive nature.
SMART CAMPUS: Ecosistema digital de internet de las cosas (IoT) como factoría de aprendizaje, conocimiento y transferencia.
Authors: Martínez Ruiz Ignacio
Published: January 2023

La Agenda Europea 2030, para cumplir con los Objetivos de Desarrollo Sostenible (ODS), establece un compromiso de mejorar la eficiencia energética en más del 30% antes de 2030. Ante este reto, la iniciativa Smart Campus de la Universidad de Zaragoza (sensorizar.unizar.es) constituye un ecosistema de Internet de las Cosas (IoT) para “medir – analizar – decidir y actuar” con el que diseñar entornos inteligentes (digital twins) como factoría de formación, concienciación y dinamización de espacios urbanos sostenibles en el ámbito de la educación digital, la eficiencia energética y las energías renovables.

En los últimos 25 años se ha trabajado mucho en simulación pero menos en experimentación y, para entender los campus universitarios como laboratorios de aprendizaje, esta iniciativa Smart Campus permite medir (niveles de CO2, temperatura, humedad, consumos, etc.), aprender de los edificios y sus instalaciones, y analizar todo tipo de información para tomar decisiones basadas en datos que permitan seguir avanzando para reducir el consumo y el impacto ambiental, mejorar el confort y, especialmente en la situación actual de pandemia, aumentar la seguridad para la salud de la personas caminando hacia un concepto innovador de smart campus.
El género cinematográfico de ciencia ficción como herramienta geoprospectiva de las ciudades
Authors: Quílez Aznar Nacho , Pueyo Campos Ángel
Published: January 2023

Las producciones cinematográficas de ciencia ficción son herramientas que pueden ayudar a preconizan y predecir o ilustrar las amenazas de las sociedades y de sus territorios y, particularmente, visualizar futuros modelos urbanos. El cine es un instrumento muy poderoso para difundir y vislumbrar cómo pueden ser las ciudades. Más allá de la evasión facilita la presentación de complejas reflexiones, teorías, utopías, sociedades, ideologías o filosofías. Este artículo, valiéndose de una selección de producciones cinematográficas de este género, visibiliza las fructíferas interrelaciones existentes entre la geografía urbana y el cine. A partir de un estudio geoprospectivo y de un análisis crítico del presente se proponen reflexiones sobre posibles futuros de nuestras sociedades y sus modelos urbanos.
Variabilidad espacial de la salud mental en Aragón y análisis de su asociación con el nivel socioeconómico: deterioro cognitivo leve y demencia
Authors: Rabanaque Hernández Isabel
Published: January 2023

Esta reseña hace referencia a la tesis doctoral denominada: Variabilidad espacial de la salud mental en Aragón y análisis de su asociación con el nivel socioeconómico: deterioro cognitivo leve y demencia; realizada por Isabel Rabanaque Hernandez y dirigida por María Zúñiga Antón y Javier Santabárbara Serrano. Fue defendida en la Universidad de Zaragoza el 14 de julio de 2022 y se puede descargar en el Repositorio Zaguan de dicha universidad.
" Ma voix devient humide (ça va, hein) " :l’expression des émotions dans "La voix du couteau" de Patrick Ness
Authors: Mochel-Caballero Anne-Frédérique
Published: January 2023

L’action de La voix du couteau, de Patrick Ness, se déroule dans un monde plongé dans le Bruit,car on y entend les pensées des autres. Todd, le protagoniste âgé de presque treize ans, voit sa viebouleversée le jour où il se trouve confronté à un silence. Riche en émotions, le récit ne tombe jamaisdans le sentimentalisme, ce qui lui permet de trouver un écho chez les adolescents des deux sexes. La raison tient en partie à la manière atypique dont ces émotions sont exprimées par le narrateur analphabète et retranscrites sur la page écrite.
Mots-clés : dystopie, science-fiction, adolescent, émotions, bruit.
Susciter l’admiration sans déclencher l’imitation : un paradoxe constitutif des personnages d’enfants soldats dans la littérature française pour la jeunesse durant la Première Guerre Mondiale
Authors: Aranda Daniel
Published: January 2023

Pendant la Première Guerre Mondiale, la littérature française pour la jeunesse propose régulièrement des histoires d’enfants soldats, fictionnelles ou pseudo-factuelles, qui se déroulent pendant le conflit en cours. Leurs auteurs cherchent souvent à faire admirer ces héros à leurs lecteurs tout en les dissuadant d’agir de même. C’est que depuis 1884 le statut d’enfant de troupe est révolu. Ainsi se met en place dans ces récits un appareil narratif et argumentatif qui cherche à atteindre cet objectif paradoxal, justifié par des raisons idéologiques mais aussi commerciales.Mots clefs : admiration, enfants soldats, Guerre de 14, imitation, littérature jeunesse.
L’éducation sentimentale dans" Le Fugitif" de Nikolaï Doubov
Authors: Chekalov Kirill
Published: January 2023

L’article est centré autour de l’oeuvre de Nicolas Doubov, un des plus remarquables écrivains soviétiques pour la jeunesse, dont les romans sont presque méconnus par la génération 2000. Dans son meilleur roman,  Le Fugitif ,  paru en 1966 (déclin du dégel dans la culture soviétique), Doubov brosse un tableau très critique de la vie provinciale peu conforme aux principes du réalisme socialiste (alcoolisme, philistinisme, hypocrisie...). Le protagoniste, Yourka, jette un défi aux philistins qui l’entourent et quitte sa famille – pour la rejoindre (enfant prodige !) lorsque son père a de gros ennuis. Son éducation sentimentale obéit donc à la logique chrétienne, chose tout à fait exceptionnelle pour la littérature soviétique adressée aux enfants.
Mots-clé : dégel, roman, adultère, alcoolisme, l’enfant prodigue, philistinisme.
Le deuil dans les récits animistes
Authors: Katagi Tomotoshi
Published: January 2023

Le deuil se retrouve au cœur de nombreux récits pour enfants, dont les tentatives d’exprimer ou inhiber la souffrance se mêlent, dans le monde occidental, fréquemment à des réflexions chrétiennes. Dans notre travail, en revanche, on se penchera sur différents contes «animistes», en commençant par plusieurs versions de Cendrillon.  Nous étudierons ensuite d’autres contes qui montrent un deuilréciproque partagé entre les vivants et les morts, dévoilant une tension entre homme et nature, afin denous interroger sur le rôle de la sensibilité animiste dans la littérature d’enfance.
Mots clef : deuil, Cendrillon, animisme, homme-nature, écologie.
La quête de la peur : du conte de tradition orale aux albums pour l'enfance
Authors: Charnay Bochra
Published: January 2023

Cet article tente de cerner les multiples configurations de la peur dans un corpus constitué de contes et de légendes issus du patrimoine oral français et de leurs réécritures à destination d’un jeune lectorat. Il s’agit essentiellement des contes et légendes bretons de François-Marie Luzel et d’Émile Souvestre ainsi que du cycle « Jean sans peur », fréquent dans toutes les régions de France. L’étude met en évidence la dimension mythique de ces récits et analyse leur évolution dans les transpositions pour la jeunesse.

Mots clés : Peur, conte, légende, Luzel, Souvestre, inquiétante étrangeté, lavandière, revenant, Ankou
Effect of Treasury Shares on Firm Value: Evidence from Korea
Authors: Kim Woojin , Im Jieun
Published: January 2023

This study examines how treasury shares held by Korea’s publicly traded firms may affect firm value. Unlike in the U.S., where repurchased shares are immediately subtracted from market capitalization, and thus, constitute a genuine payout mechanism, Korean stock market practice retains the value of repurchased shares in market capitalization, effectively treating treasury shares as a form of an asset. Korean investors do not consider share repurchase as a payout mechanism until the repurchased shares are formally cancelled. We find that share repurchases are followed by positive market reactions, which is consistent with the results of previous research, but the reactions are even larger on the cancellation disclosure date. More importantly, firms with larger treasury shares in stock exhibit a 24% lower Tobin’s q compared to those firms with smaller treasury shares. These findings suggest that the market anticipates that treasury shares may be used as a potential antitakeover measure at a later date, which is reflected in the current market value.
Kalofania w bizantyńskim i łacińskim zwierciadle
Authors: Janocha Michał
Published: January 2023

Użyty w tytule artykułu termin kalofania, czyli objawienie piękna, zostaje odniesiony do teologii piękna w tradycji chrześcijańskiego Wschodu i Zachodu, ujętych w perspektywie porównawczej. Wychodząc od hellenistycznej koncepcji piękna oraz kategorii piękna w Biblii, wskazuje rozwój teologii piękna w myśli patrystycznej i śledzi odmienne drogi w tradycji bizantyńskiej na Wschodzie oraz łacińskiej na Zachodzie.
Piękno zstępujące do otchłani w wizjach malarskich Jerzego Nowosielskiego i twórców „nowej ikony”
Authors: Mikiciuk OPs Elżbieta
Published: January 2023

Jerzy Nowosielski oraz twórcy „nowej ikony”, tacy jak Greta Leśko (Polska), Danylo Movchan (Ukraina), Sylwia Perczak (Polska), Ivanka Demchuk (Ukraina), Kateryna Kuziv (Ukraina) i Khrystyna Kvyk (Ukraina) twórczo interpretują kanon ikony, który traktują jako „żywy system formalny”. Dla wyrażenia prawd teologicznych poszukują nowych form wyrazu artystycznego poprzez dialog ze sztuką współczesną. Zstąpienie Chrystusa do otchłani postrzegają w wymiarze osobowym, komunijnym, akcentując przede wszystkim uwolnienie człowieka od stanu upadku i samotności oraz obdarowanie go życiem w jedności z Bogiem i bliźnim. W ikonie Anastasis podkreślają perspektywę egzystencjalną, ukazując zejście Piękna-Miłości do infernalnej sfery ludzkiego istnienia. W ujęciu artystów piękno sztuki, piękno zbawcze, jest chrystologiczne, ponieważ uczestniczy w procesie przemiany świata.
EXTERIOR INDICATORS OF SHEEP OF THE EDILBAEVSKY BREED OF DIFFERENT AGES
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, ERTAY A.B.
Published: January 2023

The article provides data on the exterior of sheep of the Edilbaevsky breed at the age of 2, 3, and 4 years. The exterior was studied based on the measurement of linear measurements of the articles of the body.
EXTERIOR FEATURES, GROWTH AND DEVELOPMENT OF DOWN TYVAN GOATS
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, YULDASHBAEV Yu.A.
Published: January 2023

Rough-haired goats are one of the types of domestic animals bred in Tuva. Goats are common in all natural and climatic zones of the republic. The total number of livestock in the republic is more than 13 thousand heads. Tuva coarsehaired goats are of particular value in the gene pool of agricultural animals of the republic. The paper summarizes the data on the indicators of the exterior, determines the measurements and indices of physique, the dynamics of the live weight of animals and the gains of a new downy type of goats bred in the conditions of the Republic of Tyva.