bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Hibiscus sabdariffa Aerial Parts against Pyloric Ligation-induced Ulcers in Experimental Rats
Authors: Rajesham V. V. , Raghavendra Mitta , Supriya Reddy G. , Roshan Ali P. , Rama Rao T.
Published: May 2024

The sloughing off inflammatory dead tissue is characteristic of ulcers, which are open sores of the skin or mucous membrane. Peptic ulcers are erosive lesions on the stomach or duodenal lining. The drive of the study was to evaluate the effectiveness of Hibiscus sabdariffa aerial parts extracts against pylorus ligation-induced ulcers. The extracts were prepared by maceration using ethanol and double distilled water. In the treatment schedule, Groups A and B were considered negative and standard (Lansoprazole 8 mg/kg b. wt, p.o.) controls. Groups C, D, E, and F as low (200 mg/kg b. wt, p.o.) and high (400 mg/kg b. wt, p.o.) dose treatment groups, received EEHS and AEHS, respectively. Gastric content, pH, free and total acidity, ulcer index, and inhibition of ulcer (%) were assessed. Following administration of both extracts, measurements of stomach content, free and total acidity, and ulcer index decreased. Additionally, pH increased, and a greater percentage of ulcers were inhibited. It was discovered that the ethanolic extract had significantly higher anti-ulcer action than the aqueous extract.
A Structural Equations Model Approach to Examining University Students' Acceptance of a Learning Management System
Authors: Alontaga Jasper Vincent , Sacdalan Karen , Lapinid Minie Rose , Chua Von Christopher
Published: May 2024

The study examined university students’ acceptance of a Learning Management System (LMS) during the emergency transition to online distance learning (ODL) brought on by the COVID-19 pandemic. The study involved 408 university students and employed a concurrent triangulation mixed methods design and Structural Equation Model (SEM) to investigate the Technology Acceptance Model (TAM) and several external variables, specifically social influence (SI), system characteristics (SC), individual differences (ID), facilitating conditions (FC), and academic performance. Results of SEM revealed that FC, SI, and SC are significant factors in LMS acceptance, with SC having the strongest influence on perceived ease of use (PEU) and perceived usefulness (PU). A significant path coefficient was also observed for actual use (AU) on academic performance. LMS analytics revealed the utility of discussion and assignment features of the LMS are greater over quizzes in ODL. Most students described LMS features as generally effective, particularly the use of modules, announcements, and assignments, and the provision of course materials as the best teaching practice. The quality of the Internet connectivity was determined as a major challenge affecting students’ ODL experience.
Execution Efficiency of the use of Array and Linked-List Implementations of a Stack Abstract Data Types Containing Complex Numbers in Methods of an Android Application
Authors: Košťál Igor , Mišút Martin
Published: May 2024

Abstract data types (ADTs) provide a way to define data structures and the operations allowed on them, independent of the specific implementation details. Choosing the appropriate data type is for many applications the most important step in their development that affects their performance. To investigate the most suitable stack implementation for evaluating arithmetic expressions with complex numbers, we developed an Android application. These expressions may contain a larger number of complex numbers, for example, 25, which can be enclosed in parentheses arbitrarily. The Android application uses an array and linked-list implementation of a stack ADT to evaluate these expressions in its methods, as well as a simple stack implementation that uses none ADT. We determined a more efficient implementation of a stack ADT and the most efficient implementation at all by analysing the execution times of these methods, which were evaluating the same arithmetic expressions with complex numbers. In the paper we also analyse the functioning of both these stack ADT implementations and a simple stack implementation that does not use an ADT.
Understanding the Barriers in Adopting the E-Textbooks Among Public School Students in Oman
Authors: Al Masuudi Nabawiya Khamis , Ahmad Nawi Haslinda Sutan , Osman Salyani , Al- Maqbali Hilal Ali
Published: May 2024

Advances in digital technology have been changing the way educators approach education in terms of resources and delivery of instruction through technology. Technology integration in the classroom is thought to be a successful way to motivate students. Due to benefits including portability, ease of use, and storage capacity, e-textbooks are displacing printed books as a preferred method of instruction in many nations. Research has shown that despite its many benefits, students find it challenging to adopt. This study's goal is to discover what obstacles ninth- and tenth-grade public school students in the Sultanate of Oman faced when using electronic textbooks during the COVID-19 pandemic. In total, 429 students completed the survey. The data were analysed statistically, and the research revealed that students’ attitudes toward e-textbooks were poor. Addressing barriers to the adoption of e-textbooks among school students requires a holistic approach that considers ergonomic design, technological infrastructure, and user experience. By prioritizing these aspects, among educators, publishers, and developers is crucial for creating an engaging and effective digital learning environment with e-textbooks.
The Micro-Learning Activities via Metaverse Platform: The Outcomes of Students’ at Pakse Teacher Training College, Lao PDR
Authors: Suvandy Aphinanh , Chatwattana Pinanta , Nilsook Prachyanun
Published: May 2024

The micro-learning activities via metaverse platform, or MICRO-META platform, is a research tool designated to promote learning that focuses mainly on small units of contents and learning activities that can be accomplished in a short period of time. Thereby, the micro-learning activities are facilitated by means of the so-called micro-steps under digital learning environments via metaverse. The activities of this kind are capable of providing realistic learning experiences along with ability to interact with others in the virtual world, which shall result in the exchange of information and access to varied resources. In addition, these activities are believed to increase confidence in practical skills related to the use of digital technologies. The research results show that the micro-learning activities via metaverse platform to enhance digital literacy and digital empathy can be used practically as a learning tool, and it is efficient enough to promote both digital literacy and digital empathy. Once integrated with immersive learning technologies under the virtual world, the MICRO-META platform can also encourage learners to learn by experiences and acquire new bodies of knowledge according to their own abilities.
From Education to Employment: Developing Soft Skills and Employability.Case of Cadi Ayyad University Career Center
Authors: Aissaoui Tayeb , Ouskou Rachid , Lakhlili Ibtissame
Published: May 2024

This work aims to study the role played by university career centers in strengthening the employability of young students, and more specifically the case of the career center of the Cadi Ayyad University of Marrakech. The relevance of this subject stems from the importance of improving employability, but also from the role of public institutions in supporting it in alignment with the concerns of companies. The resolution of this work involves a documentary study of the data developed by the Career Center, and more, a qualitative study of the focus group of the center's advisors.
Sentido de la vida: desafío para el heterodoxo cósmico
Authors: Rojas Vergara Emma del Pilar
Published: May 2024

Esta obra es una aproximación al pensamiento filosófico de María Zambrano, en procura de desentrañar las características más sobresalientes de la heterodoxia humana, única y reveladora entrañable de la condición de ser único y estar en relación con, que devela su presencia en el cosmos, dotado de posibilidades eficaces para responder a su inquietud filosófica sobre el sentido de la existencia. De aquí se deriva una postura filosófica que se perfila en los horizontes de la triada hombre-cosmos-sentido de la vida en procura de constituirse en la oportunidad que tiene la persona de ubicarse delante de la realidad urgida de esperanza. La exploración filosófica parte de la concepción zambraniana del “heterodoxo cósmico” que yace fundado en la obra primera de la filósofa malagueña, Horizonte del Liberalismo, hasta atravesar el resto de su obra como un tesoro escondido que solo es posible dilucidar por parte de quien emprende el esfuerzo de encontrarlo.
Search for biocontrol agents among endophytic lipopeptidesynthesizing bacteria Bacillus spp. to protect wheat plants against Greenbug aphid (Schizaphis graminum)
Authors: Rumyantsev S. D. , Alekseev V. Y. , Sorokan A. V. , Burkhanova G. F. , Cherepanova E. A. , Maksimov I. V. , Veselova S. V.
Published: May 2024

Beneficial endophytic bacteria can suppress the development of insect pests through direct antagonism, with the help of metabolites, or indirectly by the induction of systemic resistance through the regulation of hormonal signaling pathways. Lipopeptides are bacterial metabolites that exhibit direct antagonistic activity against many organisms, including insects. Also, lipopeptides are able to trigger induced systemic resistance (ISR) in plants against harmful organisms, but the physiological mechanisms of their action are just beginning to be studied. In this work, we studied ten strains of bacteria isolated from the tissues of wheat and potatoes. Sequencing of the 16S rRNA gene showed that all isolates belong to the genus Bacillus and to two species, B. subtilis and B. velezensis. The genes for lipopeptide synthetase – surfactin synthetase (Bs_srf ), iturin synthetase (Bs_ituA, Bs_ituB) and fengycin synthetase (Bs_fenD) – were identified in all bacterial isolates using PCR. All strains had high aphicidal activity against the Greenbug aphid (Schizaphis graminum Rond.) due to the synthesis of lipopeptides, which was proven using lipopeptiderich fractions (LRFs) isolated from the strains. Endophytic lipopeptide-synthesizing strains of Bacillus spp. indirectly affected the viability of aphids, the endurance of plants against aphids and triggered ISR in plants, which manifested itself in the regulation of oxidative metabolism and the accumulation of transcripts of the Pr1, Pr2, Pr3, Pr6 and Pr9 genes due to the synthesis of lipopeptides, which was proven using LRF isolated from three strains: B. subtilis 26D, B. subtilis 11VM, and B. thuringiensis B-6066. We have for the first time demonstrated the aphicidal effect of fengycin and the ability of the fengycin-synthesizing strains and isolates, B. subtilis Ttl2, Bacillus sp. Stl7 and B. thuringiensis B-6066, to regulate components of the pro-/antioxidant system of aphid-infested plants. In addition, this work is the first to demonstrate an elicitor role of fengycin in triggering a systemic resistance to S. graminum in wheat plants. We have discovered new promising strains and isolates of endophytes of the genus Bacillus, which may be included in the composition of new biocontrol agents against aphids. One of the criteria for searching for new bacteria active against phloem-feeding insects can be the presence of lipopeptide synthetase genes in the bacterial genome.
Phylogenetic and pangenomic analyses of members of the family Micrococcaceae related to a plant-growth-promoting rhizobacterium isolated from the rhizosphere of potato (Solanum tuberosum L.)
Authors: Shchyogolev S. Yu. , Burygin G. L. , Dykman L. A. , Matora L. Yu.
Published: May 2024

We report the results of taxonomic studies on members of the family Micrococcaceae that, according to the 16S rRNA, internal transcribed spacer 1 (ITS1), average nucleotide identity (ANI), and average amino acid identity (AAI) tests, are related to Kocuria rosea strain RCAM04488, a plant-growth-promoting rhizobacterium (PGPR) isolated from the rhizosphere of potato (Solanum tuberosum L.). In these studies, we used whole-genome phylogenetic tests and pangenomic analysis. According to the ANI > 95 % criterion, several known members of K. salina, K. polaris, and K. rosea (including K. rosea type strain ATCC 186T) that are related most closely to isolate RCAM04488 in the ITS1 test should be assigned to the same species with appropriate strain verification. However, these strains were isolated from strongly contrasting ecological and geographical habitats, which could not but affect their genotypes and phenotypes and which should be taken into account in evaluation of their systematic position. This contradiction was resolved by a pangenomic analysis, which showed that the strains differed strongly in the number of accessory and strain-specific genes determining their individuality and possibly their potential for adaptation to different ecological niches. Similar results were obtained in a full-scale AAI test against the UniProt database (about 250 million records), by using the AAI-profiler program and the proteome of K. rosea strain ATCC 186T as a query. According to the AAI > 65 % criterion, members of the genus Arthrobacter and several other genera belonging to the class Actinomycetes, with a very wide geographical and ecological range of sources of isolation, should be placed into the same genus as Kocuria. Within the paradigm with vertically inherited phylogenetic markers, this could be regarded as a signal for their following taxonomic reclassification. An important factor in this case may be the detailing of the gene composition of the strains and the taxonomic ratios resulting from analysis of the pangenomes of the corresponding clades.
Whole exome sequencing enables the correct diagnosis of Frank–Ter Haar syndrome in a Saudi family
Authors: Khan Y. N. , Mahmud M. Imad A.M. , Othman N. , Radzuan H. M. , Basit S.
Published: May 2024

Frank–Ter Haar syndrome (FTHS) is a rare genetic hereditary autosomal recessive disorder characterized by defective malformation of cardiovascular, craniofacial, and skeletal system. Mutations in the SH3PXD2B gene are a common cause in the development of FTHS. We recruited a family with two affected individuals (3-year-old female and 2-month-old male infant) having bilateral clubfoot. Family pedigree shows an autosomal recessive mode of inheritance. DNA was extracted from the blood samples of six members of the family. Whole exome sequencing was done for the two affected individuals and the variant was validated in the whole family by using Sanger sequencing approach. Whole exome sequencing (WES) data analysis identified a rare homozygous variant (c.280C>G; p.R94G) in the SH3PXD2B gene, and Sanger sequencing showed that the same variant perfectly segregates with the phenotype in the pedigree. Moreover, the variant is predicted to be damaging and deleterious by several computation tools. Revisiting the family members for detailed clinical analysis, we diagnosed the patients as having the typical phenotype of FTHS. This study enabled us to correctly diagnose the cases of FTHS in a family initially recruited for having bilateral clubfoot by using WES. Moreover, this study identified a novel homozygous missense variant (c.280C>G; p.R94G) in (NM_001308175.2) the SH3PXD2B gene as a causative variant for autosomal recessive FTHS. This finding supports the evidence that homozygous mutations in the SH3PXD2B gene are the main cause in the development of FTHS.
Alternative method for obtaining a quasi-monodisperse oil-water emulsion
Authors: Filipas Alexander A. , Kuchman Alyona V. , Isaev Yusup N.
Published: May 2024

Relevance. One of the priority areas of the oil and gas sector of the domestic economy is to increase the efficiency and profitability of commercial oil preparation, however, the scientific results obtained in this area are insufficient for modern technological requirements. The issues of lack of data for the development of reliable mathematical models of oil emulsion destruction, as well as input signals for regulating control of technological equipment for oil preparation, have not been resolved. Oil produced in the fields is a direct or reverse water-oil emulsion with a unique dispersed composition for each well. Currently, the size analysis of oil emulsion droplets in the field is carried out using a classical laboratory method, which has a low rate of obtaining analysis results, while the size distribution of globules carries information about such properties of the dispersed system as degradation rate, long-term stability, viscosity and others. Knowing the droplet size distribution of a particular oil emulsion, it is possible to select the most rational methods for its destruction and the necessary technical parameters of the devices used to implement these methods. In particular, when a droplet is exposed to a frequency close to its own, intensification of destruction is possible. In particular, one of the methods proposed by the authors is to bring the emulsion closer to its monodisperse version. Since it is not possible to obtain a modisperse emulsion in natural experiments, the authors propose to call this version of the emulsion quasi-monodisperse, that is, close to a monodisperse emulsion. This work examines one of the options for producing a quasi-monodisperse emulsion. Aim. To describe the method for obtaining a quasi-monodisperse medium for destroying the emulsion with a resonant frequency corresponding to the radius of the globule of the quasi-monodisperse medium. Object. Water-in-oil emulsion Methods. Thermodynamic potentials, physico-chemical hydrodynamics, differential equations. Results. The authors have obtained the differential velocity distribution function over coordinates and time, showing that the emulsion is more stable when it is finely dispersed, and estimated settling time of the dispersed phase in the emulsion. They obtained the formula that allows one to determine the minimum radius of a drop in an emulsion at a fixed pressure and temperature and another one that allows one to determine the Gibbs energy of the system. The authors managed to reduce the Navier–Stokes partial differential equations to a system of ordinary differential equations and obtain the velocity components and pressure at a known speed of rotation of the disk, and determine the mechanical moment of resistance of the disk.
Ambiente y humanos coexistimos: una perspectiva inicial para el manejo de la contaminación ambiental con residuos de fármacos en Costa Rica
Authors: Ledezma-Espinoza Aura , Calleja Amador Carlos Enrique
Published: May 2024

La contaminación con residuos de fármacos es un problema global que puede afectar la salud ambiental y pública. Sin embargo, todavía existen muchos vacíos en monitoreo, priorización de compuestos, determinación de efectos, legislación y control, especialmente en países con un menor desarrollo. En Costa Rica, los avances se han dirigido al monitoreo, resultando escasas las acciones integradas y sostenibles para estimar realmente el riesgo. La incidencia de enfermedades, consumo de medicamentos, calidad de las aguas de consumo y el tratamiento de las aguas residuales, son parámetros que pueden utilizarse para hacer una mejor estimación de este riesgo. Altos consumos de medicamentos se han registrado en la atención de enfermedades no transmisibles causantes del 81% de la mortalidad, y múltiples residuos de fármacos como sulfametoxazol, atenolol y carbamazepina se han reportado en aguas superficiales y residuales, incluso en niveles capaces de generar efectos adversos sobre especies acuáticas. El manejo de las aguas residuales mediante tanques sépticos o plantas de tratamiento primario se ha asociado como una razón de esta contaminación. Este artículo pretende explicar el contexto general de la problemática en Costa Rica, para valorar las oportunidades de prevención y mitigación, así como la necesidad de prepararse ante una eventual regulación nacional.
Les possibilités de la pisciculture pour l'alimentation des populations africaines
Authors: Letouzey R.
Published: May 2024

La carence du régime alimentaire africain en matières azotées d'origine animale a conduit à rechercher de nouvelles possibilités dans d'autres sources alimentaires.
Dans ce but, des poissons à croissance rapide et très prolifiques (en particulier des tilapias) sont élevés dans des étangs artificiels rationnellement préparés.
Cette méthode est à la portée de l'agriculteur africain, du colon et même du propriétaire forestier, et permet d'obtenir des rendements magnifiques, comme ceux obtenus au Congo belge (plusieurs tonnes par hectare et par an).
COL4A1 and Intraventricular Hemorrhage
Authors: Leite de Almeida Laura , Grangeia Ana , Sampaio Luísa , Vilan Ana
Published: May 2024

N/a.
Analysis of Environmental Factors with Dengue Hemorrhagic Fever in Guntur, Demak, Indonesia
Authors: HARIYANTI FIKA
Published: May 2024

Guntur district is one of the districts that is classified as endemic for dengue fever in Demak, Indonesia. In the last three years, there have been consecutive cases or deaths due to Dengue Hemorrhagic Fever (DHF). Based on the epidemiological triangle concept, the emergence of dengue fever can be caused by an imbalance between host (human) factors, the agent as the cause, and the supporting environment. Environmental factors facilitate contact with agents consisting of the physical, social and biological environment. The physical environment that influences the occurrence of dengue fever cases includes house layout, type of container, frequency of draining the container, availability of lids on containers, altitude and climate. DHF cases in Guntur District in 2022 were 67 cases (IR 0.8 per 1,000 population). The case sample in this study was 86 respondents consisting of 43 case groups and 43 as controls. Sampling was taken in Guntur, Demak, Indonesia. The results showed that the factors having influence on the DHF were landfill materials, landfill volume, landfill availability, frequency of landfill draining, and the presence of larvae. The risk factors for dengue fever are the material of the water reservoir, the frequency of draining the water reservoir, the volume of the landfill, and the presence of larvae. People who used cement/soil landfill materials had a 3.529 greater chance of contracting dengue fever. People with less reliable behavior in draining landfills had a 5.569 times greater chance of contracting dengue fever, and people whose water reservoirs containing larvae had a 17.939 times greater chance of contracting dengue fever.
Penerapan Modul Elektronik Sigil pada Materi Fluida Statis untuk Meningkatkan Kompetensi Pengetahuan dan Kedisiplinan Peserta Didik
Authors: Pujiyanto Febri Cahyo , Budiharti Rini , Ekawati Elvin Yusliana
Published: May 2024

This action research has the aim of (1) Improving students' knowledge ability through the application of scientific-based sigil electronic modules on Static Fluid material, (2) Increasing student discipline through the application of scientific-based sigil electronic modules on Static Fluid material. The research design is classroom action research (PTK) model Kemmis and Mc. Taggart model through two cycles. Data collection techniques used include observation techniques, tests, checklists, interviews and document reviews. Then the data analysis technique consists of qualitative and quantitative analysis. To test the validity of the data using triangulation techniques. The results showed that the application of Sigil electronic modules based on scientific material on Static Fluid was able to improve the knowledge and discipline skills of XI MIPA 3 SMA Negeri 1 Kartasura students. The percentage of knowledge ability completeness increased from 41.67% during the pre-cycle stage, to 61.11% in cycle I, and reached 91.67% in cycle II. The percentage of students' discipline achievement also increased. In the pre-cycle of 36 students, there were no students with good and very good discipline categories, increasing to 26 students with good and very good discipline and to 33 students in cycle II.
Does Using Sigil E-Modules Impact High School Students' Knowledge and Curiosity? A Quantitative Analysis
Authors: Ernawati Ernawati , Budiharti Rini , Fauzi Ahmad
Published: May 2024

This classroom action research has a purpose : (1)  Implementing the sigil e-module to increase the knowledge competence of class XI MIPA 5 students at SMA Negeri Kebakkramat for the 2021/2022 Academic Year on temperature, heat, and heat transfer, (2)  Implementing the sigil e-module to increase the curiosity of class XI MIPA 5 students at SMA Negeri Kebakkramat for the 2021/2022 academic year on temperature, heat, and heat transfer. The research model used is the model developed by Kemmis and Mc. Taggart went through two cycles. Data collection techniques in this study used observation, questionnaires, tests, interviews, and document review with data analysis techniques in the form of quantitative and qualitative analysis. The results of the study show that the application of a scientific-based sigil e-module to the material temperature, heat, and heat transfer can increase the competence of knowledge and curiosity of class XI MIPA 5 students at SMA Negeri Kebakkramat 2021/2022 Academic Year. The percentage of knowledge competence mastery increased from 33.33% in the pre-cycle to 69.44% in cycle I and increased again to 80.56% in cycle II. The achievement percentage of students' curiosity in the very good and good category increased from 15.38% in the pre-cycle to 80.56% in cycle I and again to 94.44% in cycle II. This research can be the basis for developing Sigil e-module to Temperature, Heat, and Heat Transfer material.
Development of an Enrichment Book with Hematite as a Battery Electrode in Renewable Energy Learning
Authors: Rosyidi Farisa Ramadhani , Suharno Suharno , Harjunowibowo Dewanto
Published: May 2024

Learning innovation is needed to maximize interaction between teachers and students so that learning is much more effective and efficient, one of which is through enrichment books so that students learn not only theory but also its application. Enrichment books were developed to enrich students' knowledge. In this research, an enrichment book will be created using hematite as a battery electrode in renewable energy learning. The aim of this research is to determine the development and feasibility of enrichment books using hematite as battery electrodes in renewable energy learning. Enrichment books are an innovation in education that was developed to enrich information that is not obtained from textbooks. The method used in this research is R&D. The research was carried out using the ADDIE model, but this research was limited to the development stage. The enrichment book was developed using the Canva application. The data collection technique was carried out using a purposive sampling technique. The enrichment book that has been created is validated by distributing questionnaires to expert validators and practitioner validators. The research was conducted at three schools in the Greater Solo area, namely S MA N Kebakkramat, MA Al Madinah Nogosari, and SMK Batik 2 Surakarta. The results obtained show that the enrichment book with hematite as a battery electrode can be applied in physics learning on renewable energy materials with a validation score of 68.41 or perfect criteria. This research can be the basis for developing enrichment books using hematite as battery electrodes in Renewable Energy learning.
Algılanan Örgütsel Desteğin İşle Bütünleşme Üzerindeki Etkisinde Duygusal Bağlılığın Aracı Rolü
Authors: Palabıyık Nida , Akay Esra
Published: May 2024

Amaç: Bu çalışmanın temel amacı, akademisyenlerin görev yapmakta oldukları yükseköğretim kurumuna ilişkin algıladıkları örgütsel desteğin işle bütünleşmeleri üzerindeki etkisinde duygusal bağlılığın aracı rolünü belirlemektir.
Tasarım/Yöntem: Araştırmada, kolayda örnekleme yöntemi kullanılarak devlet ve vakıf üniversitelerindeki 218 akademisyene anket yoluyla ulaşılmıştır. Elde edilen veriler, LISREL programı yardımıyla yapısal eşitlik modeliyle analiz edilmiştir.
Bulgular: Analizler sonucunda; akademisyenlerin algıladığı örgütsel desteğin işle bütünleşmeleri üzerinde doğrudan olumlu yönde bir etkiye sahip olduğu belirlenmiştir. Bu sonucun yanı sıra algılanan örgütsel desteğin duygusal bağlılık üzerinde ve duygusal bağlılığın işle bütünleşme üzerinde olumlu etkisi olduğu tespit edilmiştir. Ulaşılan nihai sonuç çerçevesinde duygusal bağlılığın, akademisyenlerin algıladıkları örgütsel desteğin işle bütünleşmeleri üzerindeki etkisinde kısmi aracı bir rol üstlendiği sonucuna ulaşılmıştır.
Sınırlılıklar: Araştırma sürecinde Türkiye’deki bütün üniversitelere ulaşılamamış olması ve anket formunda yer alan ifadelere verilen yanıtların, katılımcıların gerçek duygu ve düşüncelerini yansıttığının varsayılması, araştırmanın sınırlılıklarını oluşturmaktadır.
Özgünlük/Değer: Eğitim ve bilim alanlarında ülkelerin kalkınmasına destek olan akademisyenlerin daha verimli ve yüksek performanslı değerler üretebilmeleri için işle bütünleşmelerini sağlamak üzere çalıştıkları örgüte ilişkin algılarını ve duygularını birlikte anlamaya odaklanması, araştırmanın özgün değerini oluşturmaktadır.
Türkiye’de Bütçe Açıkları ile Ekonomik Büyüme Arasındaki İlişki: Nedensellik Analizi
Authors: Akıncı Adil , Erasa Akça İrem
Published: May 2024

Amaç: Bu araştırmanın amacı, Türkiye için geçerli olmak üzere 2006-2023 dönemindeki bütçe açıklarına yönelik gelişmelerin ekonomik büyüme üzerinde yarattığı etkilerin araştırılmasıdır. Tasarım/Yöntem: Araştırmada, Türkiye Cumhuriyet Merkez Bankası Elektronik Veri Dağıtım Sistemi ve Türkiye İstatistik Kurumundan elde edilen veriler ilk olarak Augmented Dickey –Fuller birim kök testi ile durağanlık analizine dahil edilmiş, sonrasında Hatemi-J (2012) asimetrik nedensellik testi ile pozitif ve negatif şokların etkileri ortaya konmuştur. Bulgular: Analizler sonucunda; Türkiye’de 2006:Q1-2023:Q3 döneminde bütçe açığı ve ekonomik büyüme değişkenleri arasında bir nedensellik ilişkisinin olduğu tespit edilmiştir. Buna göre; bütçe açığında meydana gelecek azalmanın ekonomik büyümeyi arttıracağı, ekonomik büyümede meydana gelecek bir daralmanın bütçe açığını arttıracağını ifade etmek mümkündür. Sınırlılıklar: Analize ilişkin verilerin Türkiye ekonomisi için geçerli olması ile birlikte bütçe açık ve ekonomik büyüme olmak üzere iki değişkenin kullanılması araştırımın sınırlılıklarıdır. Özgünlük/Değer: Bu çalışma, diğer çalışmalarda sıklıkla başvurulan Granger Nedensellik testinin aksine pozitif ve negatif şokların farklı nedensel etkilerine yer verilmesine imkan sağlayan asimetrik nedensellik testinden faydalanarak ulaştığı sonuçlar ile araştırmanın özgün değerine katkı sağlamaktadır.
Yalın Üretimin Maliyetler ve Firma Performansı Üzerine Etkisi
Authors: Çetindaş Ahmet
Published: May 2024

Amaç: Bu çalışmanın amacı, sanayi firmalarında yalın üretimin maliyetlere ve firma performansına etkisini maliyetlerin ise firma performansına etkisini araştırmaktır. .
Tasarım/Yöntem: Bu çalışmanın ana kütlesini Gaziantep Organize Sanayi bölgesinde faaliyette bulunan üreticiler oluşturmaktadır. Ana kütle içerisinde bulunan firmaların yöneticilerine anket formu uygulanmış ve toplamda 127 veri toplanmıştır. Ölçeklerin yapı geçerliliğini ve güvenirliğini belirlemek amacıyla keşfedici faktör analizi, güvenirlik analizi ve doğrulayıcı faktör analizi uygulanmıştır. Araştırmanın hipotezleri yapısal eşitlik modeli ile analiz edilmiştir.
Bulgular: Analiz sonuçları; yalın üretimin maliyeti etkilediğini ancak firma performansını etkilemediğini göstermiştir.
Sınırlılıklar: Örneklemin sadece Gaziantep organize sanayide faaliyet gösteren sanayi firmaları ile sınırlıdır. Araştırmada kullanılan değişkenlerin kapsamı faktör analizinde geçerlenen ifadeler ile sınırlıdır.
Özgünlük/Değer: Önceki çalışmalarda yalın üretim, maliyet ve performans ilişkisini ayrı ayrı incelenmiştir. Bu çalışmayı özgün kılan yalın üretimin maliyet ve firma performansına aynı anda etkisini incelemiş olmasıdır. Ayrıca önceki çalışmalar daha çok operasyonel performans üzerine etkisini incelerken bu çalışmada firma performansı finansal bir bakış açısı içermektedir.
Istiqra Al Ma'nawiy's Reasoning: As a Model of Indigenzation and Contextualization of Islamic Law (Hazairin and Hasbi Ash Shiddiqiy's Thought)
Authors: Tabroni Imam
Published: May 2024

This paper examines Asy Syatibi's legal reasoning of istiqra al-ma'nawy (thematic induction) and its impact on Indonesia's indigenization and contextualization of Islamic law. The reasoning model of Istiqra al-Ma'nawy Asy Syatibi was the study's first focus. Hazairin and Hasbi Ash Shiddiqiey are efforts to indigenize and contextualize Islam through the use of Istiqra al-Ma'nawy's method in Islamic legal reasoning. Doctrinal or normative legal research with a philosophical viewpoint A documentation model is used to collect data. This study's analytical method uses interpretive, idealistic, and holistic meta-logic. The notion of "natural law" from Islamic and customary law was applied to assess the facts. This study found that istiqra al-ma'nawy Asy Syatibi's reasoning formulation is based on a maslahah approach-based interpretation model, its idealization model is oriented toward text and context integration (tahqiq al-manath), and its holistic model is operationalized hierarchically from the top down (min al-a'la ila al-adna) and from the bottom up (min al-adna ila al-a'la). The integration and connectivity between anthropological studies of the bilateral kinship system of most Indonesian races and Asy Syatibi's legal reasoning influenced Hazairin's indigenization and contextualization of Islam. Hazairin abstracts the universal ideals in the Islamic system of inheritance via istiqra al-ma'nawy. Istiqra al-ma'nawy was used by Hasbi ash Shiddiqiey to reconcile puritanism and contextualism. The Istiqra al-Ma'nawi method strikes a balance between how law is defined (hukm taklify) and how law is made.
Homojunction-loaded inverters based on self-biased molybdenum disulfide transistors for sub-picowatt computing
Authors: Zhang Yue , Wei Xiaofu , Zhang Xiankun , Yu Huihui , Gao Li , Tang Wenhui , Hong Mengyu , Chen Zhangyi , Zhang Zheng , Kang Zhuo
Published: May 2024

As transistors are scaled to smaller dimensions their static power increases. Combining two-dimensional (2D) channel materials with complementary metal–oxide–semiconductor (CMOS) logic architectures could be an effective solution to this issue due to the excellent field-effect properties of 2D materials. However, 2D materials have limited polarity control. Here, we report a pseudo-CMOS architecture for sub-picowatt logic computing that uses self-biased molybdenum disulfide transistors. The transistors have a gapped channel that forms a tunable barrier — thus circumventing the polarity control of 2D materials — and exhibit a reverse saturation current below 1 pA with high reliability and endurance. We use the devices to make homojunction-loaded inverters with good rail-to-rail operation at a switching threshold voltage of around 0.5 V, a static power of a few picowatts, a dynamic delay time of around 200 µs, a noise margin over 90%, and a peak voltage gain of 241. Additionally, fundamental gate circuits based on this pseudo-CMOS configuration are fabricated by integrating more devices.
Comparison of Different Puncture Needles used for Endoscopic Ultrasound-Guided Fine-Needle Biopsy of Gastrointestinal Subepithelial Lesions (≤2 cm) with Respect to the Adequacy of Specimen Collection: Study protocol for a multicenter randomized prospective trial
Authors: Yamashita Yasunobu , Ashida Reiko , Shimokawa Toshio , Ikeda Tetsuya , Inatomi Osamau , Ogura Takashi , Kodama Yuzo , Takeshita Kotaro , Takenaka Mamoru , Tsujimoto Akiko , Nakai Yoshiki , Fujinaga Yukihisa , Kitano Masayuki
Published: May 2024

Background
Gastrointestinal subepithelial lesions (SELs) range from benign to malignant. Endoscopic ultrasound (EUS)-guided fine-needle biopsy (EUS-FNB) is used widely for pathological diagnosis of SELs. Early diagnosis and treatment are important because all Gastrointestinal stromal tumors (GISTs) have some degree of malignant potential. Diagnosing SELs with EUS-FNB is more difficult than diagnosing other tumors because an accurate diagnosis of GIST requires a sufficient tissue sample for immunostaining, which is part of the diagnostic protocol. Moreover, EUS-FNB is less accurate for diagnosis based on samples from SELs measuring ≤ 2 cm. However, our retrospective study showed that more than 50% of patients with SELs ≤ 2 cm were diagnosed as GIST. Therefore, EUS-FNB needles are required with adequate sampling in SELs measuring ≤ 2 cm. Previously, we conducted a retrospective single-center study of SELs measuring ≤ 2 cm, and reported that EUS-FNB with a Fork-tip needle was superior to that with a Franseen needle in that the former acquires sufficient sample. This multicenter comparative open-label superiority study is designed to verify whether a 22G Fork-tip needle is superior to a 22G Franseen needle with respect to sample acquisition.
Methods/design:
Present study will randomly assign for 110 patients (55 in the Fork-tip needle group and 55 in the Franseen needle group) with SELs measuring ≤ 2 cm, all of whom are managed at one of the 10 participating endoscopic centers. The primary endpoint evaluates the superiority of a 22G Fork-tip needle over a 22G Franseen needle for collection of an adequate tissue specimen at the first puncture. The secondary endpoints compare successful puncture rate, procedure completion rate, number of adverse events, diagnostic suitability of the first puncture specimen for GIST, and the number of punctures required until adequate specimen collection.
Discussion
The outcomes may provide insight into the optimal needle choice for diagnosis of SELs ≤ 2 cm, thereby aiding development of practice guidelines. Present study is expected to promote early definitive diagnosis of GISTs, thereby increasing the number of cases that can receive curative treatment and improving prognosis.
Trial registration:
Japan Registry of Clinical Trials (JRCT; trial registration: jRCTs052230144). Registered December 13, 2023. (URL; https://jrct.niph.go.jp/re/reports/detail/76858).
Targeting ESM1 via SOX4 promotes the progression of infantile hemangioma through the PI3K/AKT signaling pathway
Authors: Li Yanan , Kong Meng , Qiu Tong , Ji Yi
Published: May 2024

Background
Infantile hemangioma (IH) is the most prevalent benign vascular tumour in children, yet its pathogenesis remains incompletely understood. Research has established a strong association between SOX4 and tumour blood vessel formation. However, the specific role of SOX4 in IH progression has not been clearly defined. The objective of this study was to investigate the function and underlying mechanism of SOX4 in IH development, with the aim of identifying novel therapeutic targets and facilitating drug development.
Methods
The transcription factor SOX4, which is associated with IH, was identified through RNA-seq screening of IH microtumours and validated in IH tissue samples. Cell experiments were conducted to investigate the impact of SOX4 on the biological behavior of CD31+ HemECs and the PI3K/AKT pathway. Furthermore, RNA-seq analysis was performed on CD31+ HemECs exhibiting low levels of SOX4, leading to the identification of the downstream gene ESM1, which is regulated by SOX4. The targeting relationship between SOX4 and ESM1 was confirmed through database predictions and ChIP-PCR assays. Finally, the influence of the SOX4-ESM1 signaling axis on tumour growth was further elucidated through 3D microtumour models and tumour formation experiments in nude mice.
Results
During the proliferating phase, SOX4 was highly expressed in IH tissue samples and was shown to enhance the proliferation, migration, and angiogenesis of CD31+ HemECs in vitro. SOX4 was observed to bind to the promoter of ESM1, thereby transcriptionally upregulating the ESM1-mediated PI3K/AKT signaling pathway and ultimately promoting the progression of IH. The pro-proliferative effect of SOX4 on CD31+ HemECs was dependent on the expression of ESM1. Through IH 3D microtumour and in vitro animal experiments, it was demonstrated that both SOX4 and ESM1 are tumourigenic genes that independently promote tumour progression and that tumour growth could be partially reversed by knocking down SOX4 and overexpressing ESM1.
Conclusions
SOX4 plays a crucial role in the progression of IH, and the SOX4/ESM1 axis may serve as a novel biomarker and potential therapeutic target for IH.
Energy saving and carbon reduction behavior evolution between stakeholders in a joint power-carbon market: a case of China
Authors: Chen Xi , Tian Hongli , Dai Chunyan , Lin Jianyi , Bi Maoqiang , Jiang Tianyan , Tang Jia
Published: May 2024

As a country with large carbon emissions, China has made promises on carbon peaking and carbon neutralization. Since a joint power-carbon market is designed to facilitate energy-consuming enterprises (ECE) to take actions on energy saving and carbon reduction (ESCR), the investigation of the behavior evolution of different enterprise groups is of significance in predicting and evaluating the effects of carbon reduction based on the implementation of various policy packs. Consequently, within the current market and policy framework, this study establishes an evolutionary game model for ECE based on authentic Chinese data. Accordingly, the stability as well as the externality of strategy evolution are analyzed. In the case of China, results are obtained as follows: (1) The initial proportion of ECE enrolled in the ESCR strategy imposes profound impacts on the dynamic evolutionary trajectory of the system. (2) Initial strategy selections on the ESCR of high energy-consuming enterprises (HECE) or common energy-consuming enterprises (CECE) would be distracted when the key parameters, such as the power price incentive factor or carbon price are greater than the threshold value. (3) With the swift growth of the capacity and penetration of renewable energy in the grid, economically friendly policies are recommended to be given prior consideration to aggressive environmental drafts after carbon peaking.
Recovery of mining and agri-food wastes in fired materials: A case study of the Moroccan industry
Authors: Harrami Mouad , Ez-zaki Hassan , Fami Nisrine El , Khachani Nacer , Diouri Abdeljebbar
Published: May 2024

The linear economy follows the “take-make-dispose” model generates huge amounts of waste without consideration for recycling or reuse. This model which deals with raw materials puts pressure on natural resources and creates a serious environmental impact. In a circular economy, “reduce-reuse-recycle” model is applied to recycle waste into resources and reduce the impact on the environment and society. This work aims to highlight the significance of implementing a circular economy approach in the construction sector by merging two different production lines, notably mining activity and agri-food industry. The investigation presents a sustainable management of coal gangue (CG) and olive pomace (OP) in the production of eco-friendly fired materials and introduces an innovative approach for manufacturing lightweight fired bricks. Microstructural, physical, mechanical and thermal properties were determined to evaluate the technological quality of fired materials at 900°C. As a pore-forming agent, adding 10 wt% OP yielded specimens with a bulk density of 1552 kg/m³, water absorption of 19.80%, apparent porosity of 29.61%, loss on ignition of 26.98%, and compressive strength of 7.08 MPa, satisfying standards for clay masonry units. Simultaneously, it enhances the thermal insulation by reducing thermal conductivity by 18% compared to the control sample with CG. In this regard, the transition to a greener construction sector necessitates the immediate implementation of a circular economy approach to developing eco-friendly building materials by recovering large amounts of industrial waste, limiting the overuse of natural resources (e.g., clays), and improving the engineering properties of the final product.
Effects of healthy-side repetitive transcranial magnetic in patients with post stroke dysphagia: a prospective study based on functional near-infrared spectroscopic
Authors: Liu Ruyao , Li Yi , Wang Le , Li Heping , Wang Liugen , Cai Xiguo , Gou Chenggang , Song Yunyun , Zeng Xi
Published: May 2024

We investigated the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with post-stroke dysphagia (PSD). Functional near infrared spectroscopy (fNIRS) was used to investigate its possible mechanism.Patients with PSD were randomised into the intervention (rTMS) or control (shame rTMS) group.Along with conventional swallowing therapy,the rTMS group received high-frequency rTMS of the mandibular hyoid cortical region at 5 hz, and the sham rTMS group received sham stimulation. Both groups received a course of six weekly sessions for 2 weeks.At baseline and two weeks later, standardized swallowing Assessment , Penetration-Inhalation Scale and other scales were used to assess swallowing function.At the same time, we used fNIRS to detect cerebral hemodynamic changes in both groups.Two weeks after baseline, clinical assessment of swallowing function improved in both groups compared to the previous results. The results of our fNIRS subgroup analyses showed that enhanced activation mainly in dorsolateral prefrontal cortex,primary somatosensory cortex and primary motor cortex in the left group. In the right group, activation of the primary somatosensory cortex was enhanced.Our findings demonstrate that high-frequency rTMS on the healthy side improves activation of swallowing-related brain regions in PSD patients, which may help to further explore the mechanisms of recovery in PSD.
Associations of HMGB1, sTNFR-1 and NRL with the infectious premature delivery in pregnant women undergoing cervical cerclage
Authors: Cai Shengnan , Wu Yanting , Ding Yiqian , Zeng Li
Published: May 2024

ObjectiveTo investigate the associations of changes in the high mobility group box 1 (HMGB1), soluble tumor necrosis factor receptor 1 (sTNFR-1) and peripheral blood neutrophil-to-lymphocyte ratio (NLR) with the infectious premature delivery in pregnant women undergoing cervical cerclage.
MethodsSixty-seven pregnant women with premature delivery after cervical cerclage, who were treated at the Maternal and Child Health Hospital affiliated to Nantong University from January 2022 to October 2023, were enrolled, including 43 with infectious premature delivery (infectious group) and 24 with non-infectious premature delivery (non-infectious group). The pre-delivery serum levels of HMGB1, sTNFR-1 and the peripheral blood level of NRL were compared between the two groups. Further, the clinical value of these three indicators in predicting infectious premature delivery among pregnant women undergoing cervical cerclage was assessed by the receiver operating characteristic (ROC) curve analysis.
Results The infectious group exhibited significantly higher serum levels of HMGB1 (6.85 ± 2.08 mg/L), sTNFR-1 (4.77 ± 1.13 pg/ml) and peripheral blood level of NRL (6.51 ± 2.51) compared to those in the non-infectious group (4.01 ± 1.05 mg/L, 3.75 ± 0.66 pg/ml and 3.60 ± 1.48), showing significant differences (t = 7.44, 4.64 and 5.92, P < 0.05). Logistic regression analysis revealed that the HMGB1 and NRL were independent influencing factors for premature delivery (P < 0.05). According to the ROC curve analysis results, the changes in HMGB1, sTNFR-1 and NRL levels could somewhat reflect the risk of infectious premature delivery among pregnant women undergoing cervical cerclage. The AUC, sensitivity and specificity of combined detection were all markedly higher than those of independent detection.
ConclusionHMGB1, sTNFR-1 and NRL levels are the risk factors for third-trimester premature delivery among pregnant women undergoing cervical cerclage. Timely combined detection of serum HMGB1, sTNFR-1 and peripheral blood NRL at the third trimester can improve the clinical diagnostic rate, which enables early prevention to help lower the risk of premature delivery.