bluuebunny/crossref_metadata_2025 huggingface dataset:
The Constituents of the Leaves of Aristolochia Mollissima Hance
Authors: Wu Tian‐Shung , Chan Yu‐Yi , Leu Yann‐Lii
Published: May 2015

Two new sesquiterpenes, madolin‐T (1), madolin‐V (2) together with 14 known compounds were isolated from the leaves of Aristolochia mollissima. Their structures were determined by spectral analysis.
Phase Separation of n‐Propanol from Water and Extraction of Cadmium(ll) Complex into n‐Propanol
Authors: Li Quan‐Min , Liu Qi , Zhang Li‐Min , Xue Wan‐Xin
Published: May 2015

n‐Propanol can be salted out from aqueous solution by adding inorganic salts. This phase separation method has been used for the extraction of cadmium(II) as Cd(II) complex into n‐propanol phase at pH 2.0‐6.0, with 2.5 × 10−4M of Rhodamine B (RB+), 2.6 g/10 mL of ammonium sulfate as the salting‐out reagent, n‐propanol as the solvent, in the presence of 0.065 M of KI. Cd(II) was determined spectrophotometrically by measuring the absorbance at 495 nm. Various parameters influencing the phase separation and the extraction of Cd(II) have been investigated. The method is quite simple and useful; it affords binary separation of Cd(II) from Fe(III), Co(II), Ni(II), Zn(II), Mn(II)and Al(III) and is applicable to the separation of Cd(II) from synthetic samples. The extraction mechanism has been tentatively studied.
Base‐Promoted Reaction of a Cage Diketone. Novel Rearrangement to a Tricyclic Bridgehead Olefin
Authors: Chou Teh‐Chang , Wu Hui‐Juang , Liao Ju‐Hsiou
Published: May 2015

Caged diketone 1underwent the base‐promoted reaction to produce bicyclo[2.2.1]heptenyl diacid 4and tricyclic ketone 5as major products. Tricyclic ketone 5possesses a bridgehead double bond embedded in a tricyclo[5.2.1.03,8]dec‐2‐ene ring skeleton. The structures of 4and 5were unambiguously established by X‐ray crystal analyses.
Time‐Resolved Phase Transitions of the Nanocrystalline Cubic to Submicron Monoclinic Phase in Zirconia
Authors: Lajavardi Manouchehr , Kenney Donald J. , Lin Sheng Hsien
Published: May 2015

The nanocrystalline cubic, tetragonal, and submicron monoclinic phases of pure zirconia were prepared by thermal decomposition of carbonate and hydroxide precursors. The crystallization and isothermal phase transformations of the oxide were studied using high temperature X‐ray diffraction, X‐ray diffraction and Raman spectra of quenched samples. Cubic zirconia formed first, and then progressively transformed to tetragonal and monoclinic phases at temperatures as low as 320°C. The cubic, tetragonal, and monoclinic phases for ZrO2 were found to be distinct functions of crystallite size, indicating the nanocrystalline nature of these phases. They were found to exist within critical size ranges of 50 to 140 Å, 100 to 220 Å and 190 to 420 Å (±5 Å), respectively. Thus, as the crystallites grow during annealing, they first transform from cubic to tetragonal and then from tetragonal to monoclinic at critical sizes. The classical Avrami equation for nucleation and growth was applied to the tetragonal to monoclinic phase transition.
Tubular Morphology of Mesoporous Silica MCM‐41
Authors: Lin Hong‐Ping , Hwang Jyun‐Hwei , Mou Chung‐Yuan , Tang Chih‐ Yuan
Published: May 2015

We investigated detailed conditions for synthesizing the tubular form of MCM‐41 mesoporous aluminosilicate. The method is the delayed neutralization method in which the rate of neutralization is one of the controlling factors. Rapid neutralization results in the particulate form while gradual neutralization leads to tubules. It is found that the tubule morphology has several sub‐categories. There are thick‐walled, think‐walled hollow tubular MCM‐41 and solid core tubules. There are void structures in the channel framework that makes the nanochannels to be effectively interconnected.
Fullerene‐Crown Ether Coated Piezoelectric Crystal Liquid Chromatographic Detector for Metal Ions and Polar/Nonpolar Organic Molecules
Authors: Hung Chen‐Hui , Shih Jeng‐Shong
Published: May 2015

Fullerene(C60)‐dibenzo‐16‐crown‐5‐oxyacetic acid (DBI6C5‐OCH2‐COOC60) was prepared and applied as the coating material on piezoelectric quartz crystals for detection of various metal ions and polar/nonpolar organic molecules. The C60‐crown ether‐coated piezoelectric crystal sensor with a home‐made computer interface for signal acquisition and data processing was applied as an ion chromatographic (IC) detector for various metal ions, e.g., alkali metal, alkaline earth metal and transition‐metal ions. The piezoelectric detector exhibited quite good sensitivity of 104 ∼ 106 Hz/M and good detection limit of 10−3 ∼ 10−4 M for these metal ions. The C60‐crown ether piezoelectric detector compared well with the commercial conductivity detector conventionally used for metal ions. The ionic size and ionic charge seemed to have significant effect on the frequency response of the piezoelectric detector. The C60‐crown ether coated piezoelectric crystal sensor was also employed as a high performance liquid chromatographic (HPLC) detector for various polar organic molecules with frequency responses in the order: amines > carboxylic acids > alcohols > ketones. Furthermore, nonpolar organic molecules, e.g., n‐hexane, 1‐hexene and 1‐hexyne, were also detected with this piezoelectric crystal detector. The frequency responses of the piezoelectric crystal detector for these nonpolar organic molecules were in the following order: alkynes > alkenes > alkanes. The effects of solvents and flow rate on the frequency responses of the piezoelectric crystal detector were investigated. The C60‐crown ether coated piezoelectric crystal detector also showed short response time (< 1 min.) and good reproducibility.
The Low Polar Constituents from Bidens Pilosa L. var. Minor (Blume) Sherff
Authors: Chang Ming‐Huey , Wang Guei‐Jane , Kuo Yueh‐Hsiung , Lee Ching‐Kuo
Published: May 2015

Anew and 20 known compounds were isolated from Bidens pilosa L. var. minor (Blume) Sherff. The new compound was determined as 7‐phenyl‐hepta‐4,6‐diyne‐2‐ol by various physical techniques (MS, IR, UV, 1H‐, 13C‐NMR, and 2D‐NMR).
An Instrumental Correction for the Determination of Mercury in Biological and Sediment Samples Using Cold Vapor Atomic Absorption Spectrophotometry
Authors: Chen Meng‐Hsien , Chou Chiu‐Long
Published: May 2015

Low recovery rate and inconsistent measurements were found in the determination of mercury by method of cold vapor atomic absorption spectrophotometry using the hydride formation system (Hitachi HFS‐2, Hitachi Ltd., Tokyo). To overcome this problem of insufficient reaction time we developed a simple T‐joint device attaching to the commercial HFS‐2 system for the determination of mercury in various biological tissues and sediment samples. The T‐joint device was designed to combine sample and reductant injection which increased the reaction time of the sample allowing a complete formation of mercury vapor and speeding up the analysis process in comparison to the traditional cold vapor atomic absorption spectrometric method. Recoveries of mercury were in the range 95% ‐ 100%. The corrected procedure gave precise and accurate readings with several certified reference materials: NIES No. 2 from the Japan Environment Agency; IAEA‐356 from the International Atomic Energy Association, and DOLT‐2, DORM‐2, TORT‐2, PACS‐1 and MESS‐2 from the National Research Council of Canada. Simple acid digestion methods were developed based on the sample Hg level and the nature of the sample. The sample detection limits were 0.0125 μg g−1 fresh weight and 0.0625 μg g−1 dry weight for biological samples, and as low as 0.0125 μg g−1 dry weight for sediment samples. These analytical protocols we established met the general requirements in environmental research and monitoring of mercury pollution.
Total Synthesis of Carpacin and its Geometric Isomer as a Cancer Chemopreventer
Authors: Tseng Tsui‐Hwa , Tsheng Yen‐Min , Lee Yean‐Jang , Hsu Hsing‐Ling
Published: May 2015

Carpacin (1a), an antidepressant in Asiatic folk medicine from the Carpano tree, is achieved in which the longest linear sequence is only four steps in over all yield 67% from commercially available Sesamol. The key transformations in the synthesis are the selective palladium‐catalyzed coupling reactions of aryl bromide with Grignard reagents. The first preparation of its geometric isomer (1b) is described. Highlights of the synthesis include Pd‐catalyzed coupling, selective hydrogenation, and Wittig reactions. Carpacin was examined as a potential inhibitor of carcinogenesis.
NMR Study of Hetero‐Association Accompanying Self‐Association of 2‐Hydroxyl‐4‐methyl‐pyridine and 2‐Pyrrolidone in Acetonitrile
Authors: Luo Wei‐Chen , Lin Chi‐Chyuang , Lin Juh‐Ann , Dah‐YuKao  , Chen Jenn‐Shing
Published: May 2015

This work in vestigated not only the equilibrium of self‐association of 2‐pyrrolidone (A) and that of 2‐hydroxyl‐4‐methyl‐pyridine (B), but also the hetero‐association between A and B in [2H3]acetonitrile through hydrogen bonding using high‐resolution nuclear magnetic resonance spectroscopy. Dilution shift data for the protons of the NH group of A and OH group of B were measured over a wide range of temperatures and concentrations. In addition, the monomer shifts, dimer shifts and dimerization constants of self‐association and hetero‐association were evaluated using a graphic method operating on the dilution chemical shift data. The enthalpy and entropy of dimerization of self‐association and hetero‐association were also obtained from the van't Hoff plot.
Properties and Applications of Cryptand‐22 Surfactant for Ion Transport and Ion Extraction
Authors: Hwang Wen‐Yu , Shih Jeng‐Shong
Published: May 2015

A non‐ionic cryptand‐22 surfactant consisting of a macrocyclic cryptand‐22 polar head and a long paraffinic chain (C10H21‐Cryptand‐22) was synthesized and characterized. The critical micellar concentration (CMC) of the cryptand surfactant in ROH/H2O mixed solvent was determined by the pyrene fluorescence probe method. In general, the cmc of the cryptand surfactant increased upon decreasing the polarity of the surfactant solution. The cryptand surfactant also can behave as a pseudo cationic surfactant by protonation of cryptand‐22 or complexation with metal ions. Effects of protonation and metal ions on the cmc of the cryptand surfactant were investigated. A preliminary application of the cryptand surfactant as an ion‐transport carrier for metal ions, e.g., Li+, Na+, K+ and Sr2+, through an organic liquid‐membrane was studied. The transport ability of the cryptand surfactant for these metal ions was in the order: K+ ≥ Na+ < Li+ < Sr2+. A comparison of the ion‐transport ability of the cryptand surfactant with other macrocyclic polyethers, e.g., dibenzo‐18‐crown‐6, 18‐crown‐6 and benzo‐15‐crown‐5, was studied and discussed. Among these macrocyclic polyethers, the cryptand surfactant was the best ion‐transport carrier for Na+, Li+ and Sr2+ ions. Furthermore, a foam extraction system using the cryptand surfactant to extract the cupric ion was also investigated.
Rate Study of Proton Catalyzed SmI2 Reduction of 2‐Heptanone and 1,2‐Epoxydecane
Authors: Lin Tzuen‐Yeuan , Fuh Ming‐Ren , Lin Yu‐Sheng , Wen Chang‐Rong , Lin Jia‐Yung , Hu Chiao‐Ling
Published: May 2015

Rate constants directly measured from the GC‐analyzed method for SmI2 reduction of 2‐heptanone and 1,2‐epoxydecane in the presence of various proton sources were obtained. Water exhibits much stronger catalytic effect than methanol and t‐butanol. Dependence of reaction rates on concentration of SmI2 and temperature were studied.
Alkaloids from the Leaves of Fissistigma Glaucescens
Authors: Lo Wen‐Li , Chang Fang‐Rong , Wu Yang‐Chang
Published: May 2015

Two new alkaloids, glaucenamide (1) and fissiceine (2), along with fifteen known ones, liriodenine (3), oxocrebanine (4), kuafumine (5), oxoxylopine (6), atherospermidine (7), (‐)‐xylopine (8), (‐)‐N‐acetylxylopine (9), N‐trans‐feruloyltyramine (10), aristololactam BII (11), aristololactam BIII (12), aristololactam AII (13), piperolactam A (14), goniothalactam (15), norcepharadion B (16), and noraristolodione (17) were isolated from the methanolic extracts of the Fissistigma glaucescens. The structures of these compounds were established by means of spectral analysis.
Utility of (p‐Sulfonamidophenyl)azomalononitrile, and Ethyl Acetoacetate in Synthesis of Fused Azole and Azines Derivatives II
Authors: Hassanien A. A. , Amr A. E. , Ghozlan S. A. S.
Published: May 2015

[(p‐Sulfonamidophenyl)azo]malononitrile (1a,b) reacted with N‐cyclohexanemethylidene‐2‐cyanoacetohydrazide, N'‐arylmethylidene‐2‐cyanoacetohydrazide (3a‐c), S‐methylthiourea and hydrazine hydrate to afford [1,2,4]triazolo‐[1,5‐a]pyridinone derivatives (2a,b) & (4a‐c), substituted pyrimidines 5a,b and 6a,b. The corresponding pyridazinones 7a,b were synthesized from the reaction of 1c,d with ethyl cyanoacetate. Compound 7a,b reacted with elemental sulfur to yield 8a,b. Compound 6a underwent cycloaddition with α‐cinnamonitrile 9a‐e to yield 11a‐c, 14 and 15. Also, compound 6a reacted with β‐ketoester and 1,3‐diketones to give 16, 17 and 18.
Density Functional Study on the Reactivity of Carbenes Toward 1,2‐H Shifts
Authors: Hu Ching‐Han
Published: May 2015

The 1,2‐H shift reactions of simple carbenes (CH2Y‐C‐X) have been studied using density functional theory (DFT). The influence of the substituent X and Y groups on the activation energy (Ea) of 1,2‐H shifts were examined. The ‘by stander’ Y substituents lower Ea in the order of Me, F > Cl, Br > H. Our analysis shows that the X effect is more significant than the by stander Y effect. X substitutions increase Ea of carbenes in the order of F > Cl > Br > Me > H. The influence of X on Ea is governed by the singlet‐triplet energy separation (ΔES‐T) of the carbene, i.e., Ea of a carbene is larger as its ΔES‐T in creases due to an X substitution. The X effect was also found to be related to the magnitude of the exothermicity: Ea of reaction is smaller when the reaction is more exothermic. Origin of the Y effect is attributed to the inter play between two factors: ‘lateness’ of transition state on the potential energy surface, and the exothermicity of the reaction.
Synthesis and Spectroscopy of Novel‐α‐Pyrazolylglycine Derivatives
Authors: Zia‐Ul‐Haq Muhammad , Arshad Muhammad , Saeed‐ur‐Rehman
Published: May 2015

The synthesis of α‐pyrazolylglycine derivatives(7a‐d) with different substituents, starting from glycine have been pre pared. The spectroscopy of intermediate compounds and the final amino acids have been discussed.
Total Synthesis of (±)‐Eusiderin G and (±)‐Eusiderin M
Authors: Jing Xiaobi , Gu Wenxin , Ren Xinfeng , Bie Pingyan , Pan Xinfu
Published: May 2015

(±)‐Eusiderin G and (±)‐Eusiderin M were first synthesized from pyrogallol, in which the Claisen Rearrangement was used to afford two important C6‐C3 units.
Solvent‐Free Synthesis of Heterocyclic Thioureas Using Microwave Technology
Authors: Li Jian‐Ping , Luo Qian‐Fu , Wang Yu‐Lu , Wang Hong
Published: May 2015

A new and rapid solvent‐free synthesis of heterocyclic thioureas in a microwave oven has been reported for the first time. Nine heterocyclic thioureas that possess biological activity have been synthesized. The reaction time is short (2–4.5 min) and gives excellent yields (82.9–95.5%).
A New Route to N‐Aryl 2‐Alkenamides, N‐Allyl N‐Aryl 2‐Alkenamides, and N‐Aryl α,β‐Unsaturated γ‐Lactams from N‐Aryl 3‐(Phenylsulfonyl)propanamides
Authors: Wang Eng‐Chi , Huang Keng‐Shiang , Lin Gwo‐Woei , Lin Jia‐Ruei , Hsu Ming‐Kun
Published: May 2015

A series of N‐aryl 2‐alkenamides were produced efficiently by treating N‐aryl 3‐(phenylsulfonyl)‐propanamides with potassium tert‐butoxide in THF at 0°C. With out isolation, it was further treated with an additional equivalent of potassium tert‐butoxide and allyl bromide to give N‐allyl N‐aryl 2‐alkenamides in one pot in good yields. Followed by a ring‐closing metathesis reaction, these N‐allyl N‐aryl 2‐alkenamides were respectively converted into corresponding N‐aryl α,β‐unsaturated γ‐lactams in moderate yields.
Studies on Fused Azoles: Synthesis of Several Polyfunctionally Substituted Fused Azoles
Authors: Raslan M. A. , El‐Aal R. M. Abd , Hassan M. E. , Ahamed N. A. , Sadek K. U.
Published: May 2015

The synthesis of several new polyfunctionally substituted fused pyrazoles via reaction of 5‐amino‐3‐methylthio‐1H‐pyrazole‐4‐carboxylate (2) with different reagents is described.
Phenolic Compounds from Formosan Euphorbia tirucalli
Authors: Lin Shwu‐Jiuan , Yeh Chang‐Ho , Yang Li‐Ming , Liu Pang‐Chun , Hsu Feng‐Lin
Published: May 2015

Fourteen polyphenolic compounds were isolated from the 60% aqueous acetone extract of Formosan Euphorbia tirucalli L. (Euphorbiaceae). Two compounds, 5‐desgalloylstarchyurin and 3,3′,4‐tri‐O‐methyl‐4′‐O‐rutinosyl ellagic acid, were deduced by concerted application of 1D and 2D NMR methods, and reassigned their NMR data.
The Constituents of Aristolochia elegans and Aristolochia zollingeriana
Authors: Wu Tian‐Shung , Leu Yann‐Ln , Tsai Yao‐Lung , Lin Fu‐Wen , Chan Yu‐Yi , Chiang Chia‐Yu
Published: May 2015

Continuing our investigation on the bioactive compounds from the plant of the Aristolochia genus in Taiwan, we isolated one new sesquiterpene, aristololide, from the stem and roots of A. elegans, eleven known compounds from the fruits of A. elegans and nine known compounds from the fresh leaves of A. zollingeriana. Their structures were elucidated according to the 1D and 2D NMR spectroscopic analyses or by comparison with literature values.
Transformation of Ginsenosides Rg1 and Rb1, and Crude Sanchi Saponins by Human Intestinal Microflora
Authors: Lin Mei‐Chih , Wang Kuang‐Chao , Lee Shoei‐Sheng
Published: May 2015

Fractions major in ginsenosides Rg1 and Rb1 from Sanchi saponins were transformed by human fecal flora. This study yielded the corresponding aglycone, protopanaxatriol, in 49.4% from Rg1, protopanaxadiol 20‐O‐glucoside in 54.8% from Rb1, and dihydroprotopanaxadiol 20‐O‐glucoside in 87.6% from dihydro Rb1, by incubation with healthy feces for 70 h in subgram level. Never the less large‐scale incubation of crude Sanchi saponins revealed the complete biotransformation of Rb1 and the almost unchanged Rg1. A small amount of Rg1 was found to be converted into 20 R‐ginsenoside Rh1 and its dehydration product, 20(22) Z‐ginsenoside Rh4.
Synthesis and Antifungal Activities of ω‐[4‐Aryl‐5‐(1‐phenyl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐1,2,4‐triazol‐3‐thio]‐ω‐(1H‐1,2,4‐triazol‐1‐yl)acetophenones
Authors: Chu Chang‐Hu , Hui Xin‐Ping , Zhang Yan , Zhang Zi‐Yi , Li Zhi‐Chun , Liao Ren‐An
Published: May 2015

New 4‐aryl‐5‐(1‐phenyl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐1,2,4‐triazol‐3‐thiones 3 have been synthesized by the intramolecular cyclization of 4‐aryl‐1‐(1‐phenyl‐5‐methyl‐1,2,4‐triazol‐4‐formyl)thiosemicarbazides 2 with an 8% NaOH solution, and then 3 reacted with ω‐bromo‐ω‐(1H‐1,2,4‐triazol‐1‐yl)acetophenone to afford ω‐[4‐aryl‐5‐(1‐phenyl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐1,2,4‐triazol‐3‐thio]‐ω‐(1H‐1,2,4‐triazol‐1‐yl)‐acetophenones 4. The preliminary biological test showed that the representative compounds possess some anti fungal activities.
A Comparative Study of Hydrogen Bonding Using Density Functional Theory
Authors: Lai Chun‐Chia , Shen Chien‐Chern , Hu Ching‐Han
Published: May 2015

The hydrogen‐bond energies of water dimer and water‐formaldehyde complexes have been studied using density functional theory (DFT). Basis sets up to aug‐cc‐pVXZ (X=D, T, Q) were used. It was found that counterpoise corrected binding energies using the aug‐cc‐pVDZ basis set are very close to those predicted with the aug‐cc‐pVQZ set. Comparative studies using various DFT functionals on these two systems show that results from B3LYP, mPW1PW91 and PW91PW91 functionals are in better agreements with those predicted using high‐level ab initio methods. These functionals were applied to the study of hydrogen bonding between guanine (G) and cytosine (C), and between adenine (A) and thy mine (T) base pairs. With the aug‐cc‐pVDZ basis set, the predicted binding energies of base pairs are in good agreement with the most elaborate ab initio results.
The Synthesis of N‐(Glycosylthioureylene)‐aminothiophosphonic and ‐diaminothiophosphinic O‐aryl Esters
Authors: Cao Ling‐Hua , Zhou Chuan‐Jian , Gao Hong‐Yun , Liu Yu‐Ting
Published: May 2015

Reactions of O‐aryl dihydrazinothiophosphinates (4, 5) or O,O′‐diarylhydrazinothio‐phosphonates (2) with glycosyl isocyanates (6) gave corresponding N‐(glycosylthioureylene)‐aminothiophosphonic and ‐diaminothiophosphinic O‐aryl esters. Their structures were confirmed by IR, 1H NMR, 31P NMR, MS and elemental analyses.
The Reaction Studies of α‐Chloroformylarylhydrazines with Thiols, Thioureas and α‐Cyclodiketones
Authors: Kuo Wen‐Fa , Wu Ming‐Shyue , Chiu Chun‐Yen , Yeh Mou‐Yung
Published: May 2015

The reactions of α‐chloroformylarylhydrazines 1 with various types of mercaptan, thiourea and α‐cyclodiketone have been studied intensively. 1‐Arylhydrazinecarbothioates 2 were obtained via thioesterization when α‐chloroformylarylhydrazines reacted with thiols. On the other hand, compounds 3 were obtained when α‐chloroformylarylhydrazines reacted with thio‐containing heterocyclic compounds, which suggested a totally different mechanism in these types of reactions. Further studies on the reaction of α‐chloroformylarylhydrazines 1 with thiourea compounds confirmed a novel cyclization and de‐cyclization mechanism, which led to give 2‐arylhydrazinecarboximidamides 5 and 1,3,4‐thiadiazolin‐5‐ones 6. In addition, various 1,3,4‐oxadiazines 9 were obtained by reacting α‐chloroformylarylhydrazines with α‐cyclodiketones, showing ring cyclization was involved in this type of reaction.
Ptychantins from the Liverwort Ptychanthus Striatus
Authors: Wu Chia‐Li , Wang Chien‐Jen , Yin Ming‐Horng
Published: May 2015

Five new ptychantins, J‐N, along with two known ones, G and I, were isolated from the liverwort Ptychanthus striatus. Their structures were established by NMR spectroscopic analyses.
Rydberg and Doubly Excited States of Na2 and Li2
Authors: Li Li , Liu Yaoming , Lyyra A. Marjatta
Published: May 2015

Rydberg and doubly excited states of Na2 and Li2 have been studied by optical‐optical double resonance (OODR) excitation spectroscopy. In this short review article we summarize the Rydberg states and doubly excited valence states of Li2 and Na2 that have been observed experimentally. We also give experimental evidence for the electronic characteristic differences between these two types of electronic states observed in our experiments.
Present Status of Highly Charged Ion Experiments with an ECR Ion Source at TMU
Authors: Tanuma Hajime , Matsumoto Jun , Nishide Tatsuhiro , Shiromaru Haruo , Kobayashi Nobuo
Published: May 2015

A highly charged ion facility built around a 14.25 GHz electron cyclotron resonance ion source has been constructed for the experimental investigation of low energy atomic collisions in Tokyo Metropolitan University. Four kinds of different experiments, namely differential scattering of electrons from ions, polarization spectroscopy for charge transfer reactions, Coulomb‐explosion‐imaging of molecular ions, and secondary ion measurements from solid surfaces, are taking place in parallel in this facility. General features of the facility and some recent results are described in this paper.
Atomic Structure Studies Using Tokamak Plasmas
Authors: Martinson Indrek , Jupén Christer
Published: May 2015

Atomic processes play an important role in thermonuclear fusion research. In magnetically confined fusion plasmas atomic processes influence the energy balance of the plasma and the impurity transport. It has been known for more than 30 years that line radiation from plasma impurities will lead to energy losses and plasma cooling. However, the impurities are useful in plasma diagnostics. These facts have motivated intense spectroscopic work, using a variety of methods, in order to produce the atomic data needed by the fusion community. The spectroscopy of fusion plasmas has also yielded a wealth of new data for atoms and ions. A fusion plasma is an excellent light source ‐ with some unique properties ‐ for the spectroscopy of highly charged ions. Some examples will be discussed in this paper.
Giant Resonance in 4d Photo‐Ionization and ‐Excitation of High Z Atoms and Ions; Systematic Study of Dynamic Electron‐Correlation
Authors: Watanabe Tsutomu , Tong Xiao‐Min , Sato Masashi , Ohtani Shunsuke
Published: May 2015

For the study of so‐called 4d giant resonance of an Xe atom and its iso‐electronic sequence, the linear response method with the density functional theory is applied. Particular attention is made for the 4d photoexcitation process of Xe together with the continuum spectrum and the excitation peaks in the experiment are identified for the first time. Systematic study for iso‐electronic sequence of Xe‐like ions and atoms, i.e., I−, Xe, Cs+, Ba++ and La3+ are reported in order to see the role of the dynamic electron correlation to 4d‐photoexcitation/ionization processes.
Comparison of Excitation Processes by Proton and Antiproton Impacts on Hydrogen Atoms; Direct Solution of Time Dependent Schrödinger Equation
Authors: Watanabe Tsutomu , Tong Xiao‐Min , Kato Daiji , Ohtam Shunsuke
Published: May 2015

Making use of the direct solution for Schrödinger equation, the impact excitation of hydrogen atoms by proton and anti‐proton is studied. For the trajectory of projectile particles, we apply the straight line as well as curved trajectory. In order to save the number of glid, we employ the split‐operator method and pseudospectral (non‐uniform mesh) in energy representation. The calculations are compared with previous works of the traditional closed coupling impact parameter method and that of direct solution method. Comparison between the results of proton and anti‐proton impacts are physically discussed.
Photoionization Profiles of Helium Autoionizing States in External DC Electric Fields
Authors: Ho Yew Kam , Fang Te‐Kuei
Published: May 2015

Electric‐field effects on the doubly excited resonant structures in He ground state photoionization are investigated theoretically using the complex‐rotation method with a B‐spline‐based configuration interaction (BSCI) basis. The variations of the structure profiles for the ML = 0 components of He (2,2a), (2,3 a), and (2,4a) 1P° and 1De resonance pairs for selected DC electric field strengths are examined. The changes of the resonant energies, widths, Fano q‐parameters, and back ground cross sections, are also presented.
A Model Study of High Harmonic Generation from Ions
Authors: Choi Jung‐Seock , Nam Baek Il , Kim Young Soon , Baik Moon‐Gu
Published: May 2015

We have studied the influences of atomic parameters and laser parameters with various atomic potentials and laser intensities on high harmonic generation (HHG) by solving the time‐dependent 1‐D Schrödinger equation with a soft‐core model potential. For these purposes we examine harmonic spectra for the cases of deeply bound initial states of ions in the hydrogen isoelectronic sequence. The harmonic signals for the lower order harmonics rapidly decrease so that the harmonic spectrum reveals a ‘well’ structure in the region of lower order harmonics, which is not common in the ordinary high harmonic spectrum. In order to explain the origin of this feature we also calculate HHG spectra for the cases where the excited states are initially populated. These studies naturally require considerations of quantum effects that are normally neglected, by which we under stand the limit of the semi‐classical theory of HHG.
A Proposal for Guiding and Trapping of Cold Atoms in the AC Field of Current‐Carrying Wires
Authors: Xu Lifang , Yin Jianping , Wang Yuzhu
Published: May 2015

We propose a novel ac electro‐magnetic guiding and trapping of cold neutral atoms, which is based on the interaction of a magnetic dipole moment of guided and trapped atom with both an ac quadrupole magnetic field in the trans verse direction and a dc‐bias magnetic field along the guiding axis. The time‐averaged magnetic potential and force for the atoms are calculated. And the results show that the potential is high enough to collect and guide nearly all of the cold atoms from a standard magneto‐optical trap with a temperature of ∼ 120 μK.
Study of Photodissociation Dynamics Using Sub‐Doppler Fluorescence Imaging Method: Photodissociation of ICN at 308 nm
Authors: Chang Jia‐Lin , Chen Kuo‐Mei , Lin Wei‐Yu , Chen Yit‐Tsong
Published: May 2015

The sub‐Doppler fluorescence imaging method has been developed to determine velocity distribution, angular distribution, and vector correlation of state‐selected photofragments. Using this new method, photodissociation dynamics can be studied directly in the center‐of‐mass frame, even with an uncollimated molecular beam. We have performed the experiment of photodissociation of ICN at 308 nm to demonstrate that recoil velocities of photofragments can be obtained with out collimating the parent beam. The forward‐ and backward‐scattered CN(X 2Σ+) photofragments are imaged simultaneously for the first time. The recoil velocities of the CN photofragments are measured and the bond dissociation energy D00(I–CN) is determined to be 26960 ± 120 cm‐1, in agreement with the literature values reported recently.
Sum Frequency Vibrational Spectroscopy of the Liquid‐Air Interface of Aqueous Solutions of Ethanol in the OH Region
Authors: Ju Shan Shan , Wu Tzong‐Daw , Yeh Yuh‐Lin , Wei Tai‐Huei , Huang Jung‐Yaw , Lin Sheng Hsien
Published: May 2015

The surface vibrational spectroscopy of ethanol (C2H5OH, ethyl alcohol): water binary mixture, or the aqueous solution of ethanol, is investigated via sum frequency generation (SFG) in the OH region (3000 to 3900 cm−1). The bulk molar ratio of the ethanol is varied from x = 0.0024 to 0.20. Our concentration dependence results support the statement that the surface density of water molecules with a free dangling OH bond is about 25% in the air/water interface. It also indicates that the ethyl group of the surface ethanol molecules sticks out above the nominal surface, while the hydroxyl group alone is immersed in the mixture solution. And the surface layer is a mixed monolayer. We have demonstrated here that a LiNbO3 crystal containing ‐OH can be sufficient for the SFG spectroscopy measurement in the ‐OH region regardless of its absorption dip.
Electronegativity Scaled as a Average Attracting Energy of Valence‐Shell Electrons in a Ground‐State Free Atom
Authors: Xia Zhining , Shen Qiting , Cao Chenzhong , Huang Ying , Li Shengshi Zhiliang
Published: May 2015

The total capability of an atom attracting valence electrons can be measured by the sum of ionization energies of valence electron in a ground‐state free atom plus its electron affinity called Total Attracting Energy, TAE = ΣniEi + EA, where, Ei is the ionization energy of the ith valence‐shell electron in a ground‐state free atom, ni is the number of valence‐shell electron bearing energy Ei, and EA is the electron affinity. And the electronegativity χCL is proportional to the average of TAE, AAE = TAEav, divided by Σni, the number of atomic valence‐shell electrons. χCL = 0.1813 TAEav = 0.1813 AAE = 0.1813 TAE/Σni, = 0.1813 (ΣniEI + EA)/Σni. Further, the atomic valence orbital electronegativity can be also obtained from the TAE value of an atom. Some discussions were made on several special aspects such as scale of rare gases, comparisons with Pauling's and Allen's scales, etc.
Solid‐State NMR Study on Relationships between Miscibility and Chain Mobility in Poly(4‐Methylstyrene)/Poly(Cyclohexyl Methacrylate) Blend
Authors: Wu Ru‐Rong , Kao Hsien‐Ming , Jang Fan‐Hwei , Woo E. M.
Published: May 2015

The phase behavior and motional mobility in binary blends of poly(4‐methylstyrene) (P4MS) and poly(cyclohexyl methacrylate) (PCHMA) have been examined by 13C solid state NMR techniques. The blend miscibility was studied by measuring the 1H spin‐relaxation times in the laboratory frame (T1H) and in the rotating frame (T1ρH), respectively. Although intermolecular spin diffusion contributes to the proton relaxations in accordance with homogeneity, T1ρH data shows signs of in complete averaging. The T1ρH relaxation behavior indicates the existence of heterogeneous do mains with shortest dimensions in the nanometer range, which is also sup ported by the intermolecular cross polarization experiments with variable contact times. In addition, according to the resuits of carbon T1ρ relaxation time measurements, it is concluded that mixing is intimate some what enough to cause a reduction in local chain mobility for P4MS and vice versa for PCHMA.
Nuclear Magnetic Resonance Study of the Stoichiometry and Stability of Several Li+‐Crown Ether Complexes in Various Acetonitrile‐Nitrobenzene Mixtures
Authors: Karkhaneei Ebrahim , Zebrajadian Mohammad Hasan , Shamsipur Mojtaba
Published: May 2015

Lithium‐7 NMR spectrometry was used to study the complexation reaction between lithium ions and several 12‐, 15‐ and 18‐membered crown ethers in a number of binary acetonitrile‐nitrobenzene mixtures. Formation constants of the resulting 1:1 complexes in different solvent mixtures were determined by computer fitting of the chemical shift‐mole ratio data. There is an inverse relationship between the complex stability and the amount of acetonitrile in the mixed solvent. Among different sized crown ethers used, 15‐crowns were found to form the most stable Li+ complexes in the series. The influence of substitution on the macrocyclic rings on the stability of the resulting complexes is discussed.
A Bipotentiostat Based 4‐Electrode Detection System for HPLC Analysis
Authors: Chao Ming‐Huei , Huang Hsuan‐Jung
Published: May 2015

With the assist of a microcomputer interfacing, a bipotentiostat in corporated 4‐electrode detection system was developed as a versatile electrochemical detector for HPLC. An amperometric chromatogram and two three‐dimensional chromatovoltammograms characterizing the electrochemical characteristics of analytes can be obtained in a single chromatographic run. By following the three operation modes developed, both the oxidizable and reducible analytes contained in sample solutions can be determined. The analytical capability of the 4‐electrode detection system was demonstrated by the analysis of solutions containing hydroquinone, catechol and ascorbic acid. From the calibration graphs obtained, linear coefficients better than 0.9992 were found for hydroquinone and catechol in a concentration range of 1.0 × 10−4 to 1.0 × 10−7 M, and a linear coefficient of 0.9929 was found for ascorbic acid in a concentration range of 1.0 × 10−4 to 1.0 × 10−6 M. The detection limits (based on S/N = 3) found were about 1.0 × 10−7 M for hydroquinone and catechol and was 1.0 × 10−6 M for ascorbic acid.
Alkaloids from Lindera Glauca
Authors: Chang Yuh‐Chwen , Chen Chung‐Yi , Chang Fang‐Rong , Wu Yang‐Chang
Published: May 2015

A new amide, N‐cis‐sinapoyltyramine (1), and twelve known compounds were isolated from the aerial parts of Lindera glauca. The structure of the new compound has been established by the study of extensive 2D NMR data.
New Sesquiterpenes from the Roots and Stems of Aristolochia Mollissima
Authors: Wu Tian‐Shung , Chan Yu‐Yi , Lin Fu‐Wen
Published: May 2015

Two new sesquiterpenes, madolins Y (1) and Z (2) were isolated from the dried roots and stems of Aristolochia mollissima, and their structures were determined by spectroscopic methods.
Acid Catalyzed Dissociation of 4‐Aminopyridine Complex of Pentacyanoferrate (II)
Authors: Chen Mei‐Ling , Yeh Andrew
Published: May 2015

Fe(CN)5ampy3− (ampy = 4‐aminopyridine) complex was unstable at pH ≤ 4 with respect to the dissociation due to the protonations of the complex. The first protonation on the 4‐aminopyridine ligand at pKa = 3.2 resulted in a ≅ 150‐fold in crease in rate of dissociation as compared to that of the complex in the neutral solution. However, further protonation of the complex on the cyanide ligand at pKa = 1.5 in creased the rate only slightly. The large in crease in the rate constant of dissociation for Fe(CN)5ampyH2− complex suggests that in the transition state the proton is likely shifted from the amino group and becomes coordinated to a pair of dπ electrons directed at the face of the coordinated octahedron.
The Syntheses and Reactions of 3‐Arylsydnone‐4‐carboxamide Phenylhydrazones
Authors: Shih Mei‐Hsiu , Lu Li‐Hui , Yeh Mou‐Yung
Published: May 2015

Reactions of aniline with 3‐arylsydnone‐4‐carbohydroximic acid chlorides (1) gave the de sired substitution products5. 3‐Arylsydnone‐4‐carboxamide phenylhydrazones (7) were obtained unexpectedly by the reaction of carbohydroximic acid chlorides1with phenylhydrazine in suitable conditions. Compounds7could react with both aromatic and aliphatic aldehydes in the presence of acid catalyst to give 3‐aryl‐4‐(1′‐phenyl‐5′‐substituted‐1′,2′,4′‐triazol‐3′‐yl)sydnones (11).
Synthesis of Some New Spiro, Isolated and Fused Heterocycles Based on 1H‐indole‐2‐One
Authors: El‐Emary T. I. , Ahmed R. A. , Bakhite E. A.
Published: May 2015

The reaction of 3‐benzoylcyanomethylidine‐1(H)‐indole‐2‐one (1) with a variety of active methylene compounds, thioglycolic acid, glycine, hydrazine hydrate and phenyl hydrazine led to the formation of compounds 4a‐d‐10. 3‐Thiosemicarbazide‐1(H)‐indole‐2‐one 2 on reaction with α‐halocarbonyl compounds gave compounds 11a‐c, 12a‐c. The latter compounds on heating with phosphoryl chloride, cyclization takes place via losing water to give the angular tetracyclic compounds 13a,b and 14a‐c. Cyanoacetic hydrazone derivative 3 readily cyclized upon heating in triethyl orthoformate to give the tricyclic system, oxopyridazino indole 15.

On the other hand, the reaction of 3 with benzylidine malononitrile and benzylidene ethylcyanoactate gave the pyranyl hydrazone derivatives 16a,b.
Two Polymeric Linear Tri‐nickel(II) Complexes: [Ni3(μ3‐dpa)4(C4O4Me)]n(BF4)n and [Ni3(μ3‐dpa)4(N3)]n(PF6)n Synthesis, Structural Characterization and Magnetic Properties
Authors: Peng Chi‐How , Wang Chih‐Chieh , Lee Hsiao‐Ching , Lo Wei‐Chung , Lee Gene‐Hsiang , Peng Shie‐Ming
Published: May 2015

Two new linear tri‐nickel(II) complexes with an infinite polymeric chain, [Ni3(μ3‐dpa)4(C4O4Me)](BF4) 1 and [Ni3(μ3‐dpa)4(N3)](PF6) 2, [dpa− = di(α‐pyridyl)amido anion], have been synthesized and their structures were determined by X‐ray diffraction. Compound 1 crystallizes in the monoclinic system, space group C 2/c, with a = 19.9078(3), b = 13.2986(2), c = 37.6622(5) Å, β = 94.091(1)°, Z = 8. Compound 2 crystallizes in the monoclinic system, space group P 21/n, with a = 13.323(4), b = 23.217(3), c = 17.528(5) Å, β = 94.42(3)°, Z = 4. The two complexes are described as one‐dimensional systems with the (C4O4Me)−, 1, or N3−, 2, serving as a μ‐(1,3) bridged ligand at the two axial sites of each [Ni3(μ3‐dpa)4]2+ fragment. The Ni‐Ni distances of 2.400(1) and 2.402(1) in 1 and 2.389(2), 2.385(2) in 2 are obviously shorter than those of 2.4325(7), 2.4356(7) in the monomeric complex [Ni3(μ3‐dpa)4(N3)2] 3. The magnetic properties of complexes 2 and 3 were studied by susceptibility measurements vs temperature. The χM vs T plots of both complexes show a strong antiferromagnetic behavior. The simulated J13 values are −95 cm−1 and −97 cm−1 for 2 and 3, respectively.
Analysis of Polymer Additives by Matrix‐Assisted Laser Desorption Ionization/Time of Flight Mass Spectrometer Using Delayed Extractionand Collision Induced Dissociation
Authors: Hsiao Shih Tsung , Tseng Mei Chun , Chen Yet Ran , Her Guor Rong
Published: May 2015

Matrix‐assisted laser desorption/ionization (MALDI) in combination with mass spectrometry proved to be a viable method for identifying additives in polyethylene ex tracts. The MALDI mass spectra of additives standards were found to be very simple consisting of [M+H]+ and/or [M+Na]+ pseudo molecular ions with little fragment ions. For real samples, which of ten contain more than one additive, the production of only one or two ions for each additive makes the tentative assignment much easier. Collision induced dissociation (CID) of the pseudomolecular ion is used to confirm the tentative assignment. The analysis of highmolecular weight additives, such as Chimassorb 944 and Tinuvin 622 indicated that MALDI was superior to other ionization techniques such as electrospray ionization (ESI), desorption chemical ionization (DCI) and fast atom bombardment (FAB) in the analysis of high molecular weight polymer additives. Sample preparation was found to be more critical than DCI in the analysis of real sample. The signals were interfered by the low molecule weight polyethylenemolecules, which were co‐extracted with the additives. This problem was partially overcome by using acetone in stead of methanol to precipitate the low molecular weight polyethylenemolecules.
Chemically Bonded Fullerene C60 Capillary Column for the Electrophoretic Separation of Plant Phenols
Authors: Shiue Chia‐Chann , Lin Shu‐Yu , Liu Chuen‐Ying
Published: May 2015

A novel mixed‐mode stationary phase for open tubular capillary electrochromatography (CEC) was prepared. With 3‐aminopropyltrimethoxysilane as the spacer, the chemical reagent in conjunction with the fullerene played an important role in the electrochromatographic separation of the plant phenols. The fullerene C 60‐based column has the properties of both hydrophilic and hydrophobic interaction sites and provides a positively charged capillary surface responsible for the reversed electroosmotic flow (EOF) in the column during CEC operation. Comparative studies for the fullerene‐bonded phase, the intermediate phase with amino group and the bare fused‐silica were carried out. Under the conditions of acetate buffer (20 mM, pH 5.0) and applied voltage of −15 kV, the separation of catechin, salicylic acid, myricetin, quercetin, gallic acid, caffeic acid and p‐coumaric acid could be achieved. The proposed method was also applied to the analysis of plant phenols in grape juice.
Organic Amorphous Material N.N.N.N′‐tetraaryl(Ar12Ar22)‐1,1′‐biphenyl‐4,4′‐diamine
Authors: Maiti B. C. , Wang S. Z. , Cheng C. P. , Huang D. J. , Chao C.‐I.
Published: May 2015

A series of N,N,N,N′‐tetraaryl(Ar 12Ar22)‐1,1′‐biphenyl‐4,4′‐diamine were synthesized by the Pd(0) catalyzed C‐N bond formation methodology. The physical properties, including glass transit ion temperature (Tg), melting point (Mp) and oxidation potential were measured. For Ar1 = 2‐naphthyl and Ar2 = 3‐toly (4f) and Ar2 = 3‐ethylphenyl (4h), the DSC charts indicate that they have Tg, but no observable Mp. These two compounds are amorphous in solid state. The X‐ray powder diffraction pat tern of4f further confirmed that it is truly amorphous through out the temperature range in which it is solid. There fore, we have demonstrated that a low molecular weight organic solid can be amorphous. This is an important aspect in the prep a ration of morphologically stable amorphous thin film. Other compounds with Ar1 = Ph, 1‐naphthyl while Ar2 = 3‐toly or 3‐ethylphenyl are normal compounds with both Tg and Mp when prepared in their glassy state by rapid cooling of their melt. The oxidation potentials for compounds with Ar1 = 1‐naphthyl and 2‐naphthyl and identical Ar2 are exactly the same. The molecular structural features must be important factors for an organic solid to be in the amorphous state.
Enantioseparation of Amino Acids and Amino Alcohols on a Chiral Stationary Phase Derived from L‐Alanyl‐ and Piperidinyl‐Disubstituted Cyanuric Chloride
Authors: Lin Chen‐Hsing , Lin Ching‐Erh , Chen Chia‐Chong , Liao Li‐Fang
Published: May 2015

A silica‐base chiral stationary phase (CSP) derived from L‐alanyl‐ and piperidinyl‐disubstituted cyanuric chloride was prepared for the enantioseparation of methyl esters of N‐(3,5‐dinitrobenzoyl)amino acids and amino alcohols. This CSP provides good chiral recognition and effective separation of enantiomers of both methyl esters of N‐(3,5‐dinitrobenzoyl)amino acids, except for proline, and N‐(3,5‐dinitrobenzoyl)amino alcohols by high‐performance liquid chromatography. The enantioselectivity depends mainly on three preferential interactions which include a π‐π interaction and two hydrogen‐bonding interactions. However, steric interaction between substituents attached to the chiral center of chiral selectands and the chiral selector also plays a significant role in chiral recognition. Comparison of chromatographic results of the CSP prepared in this study with those of the CSP containing pyrrolidinyl group attached to the s‐triazine moiety, reported previously (J. Chromatogr. A, 722 (1996) 189), reveals that influences of steric interaction and the basic nature of piperidinyl substituent attached to the s‐triazine ring of the chiral selector on chiral discrimination may not be neglected.
Water‐Exchange and Relaxometric Studies of Gd(III) Complexes with DTPA‐bis(amide) Ligands
Authors: Cheng Tsan‐Hwang , Lin Kuei‐Tang , Ou Ming‐Hung , Shih Hsin‐Ling , Liu Gin‐Chung , Wang Yun‐Ming
Published: May 2015

The water 1H and 17O NMR relaxation properties of aqueous solutions containing Gd(III) che lates of the DTPA‐BIPA, DTPA‐BAA, DTPA‐BDEA and DTPA‐BMA ligands were investigated, and the results were compared with those previously reported for the Gd(III) complex with DTPA ligand. The significant deviation from the monoexponential behavior at the estimation of temperature dependence of 1H longitudinal relaxation rate for Gd(III) complexes with DTPA‐BIPA, DTPA‐BAA and DTPA‐BDEA ligands is characteristic of the slow chemical ex change. The measurements of 17O NMR trans verse relaxation rates and EPR transverse electronic relaxation rates in the range 276–343 K, allowed the assessment of the water‐exchange lifetime between the coordination site and the bulk solvent. With this approach, we obtained the water‐exchange life time (τM) of 1515, 1429, 1538 and 2128 ns for [Gd(DTPA‐BIPA)(H2O)], [Gd(DTPA‐BAA)(H2O)], [Gd(DTPA‐BDEA)(H2O)] and [Gd(DTPA‐BMA)(H2O)], respectively. Compared with the τM value of 303 ns for [Gd(DTPA)(H2O)]2−, we are able to conclude that the water residence life time in creases when the two terminal carboxylate groups of DTPA were substituted by two amide groups.
Indirect Determination of Thiocyanate with Ammonium Sulfate and Isopropyl Alcohol by Extraction‐Flotation of Copper
Authors: Shen Yi‐Yang , Xing Yun , Li Quan‐Mm
Published: May 2015

A new method for the in direct determination of thiocyanate with ammonium sulfate and isopropyl alcohol by extraction‐flotation of cop per in the presence of ascorbic acid is described. A small amount of Cu(II) is reduced to Cu(I) by ascorbic acid, then Cu(I) is precipitated with SCN−. In the course of phase separation of isopropyl alcohol from water, the precipitated CuSCN stays in the interface of isopropyl alcohol and water. A good linear relationship is observed between the flotation yield of Cu(II) and the amount of SCN−. The detection limit for thiocyanate is 1.0 × 10−5 M, and the linear range is 1.0 × 10−5 ∼ 7.8 × 10−5M. Every parameter was optimized and the reaction mechanism was studied. The method is simple and rapid and it was successfully applied to the determination of thiocyanate in urine and saliva of smokers and non‐smokers and in venous blood of patients in fused with sodium nitroprusside.
Synthesis of Some New Pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4(3H)‐Ones and Pyrido[3′,2′: 4,5]thieno[2,3‐e]‐1,2,4‐triazolo[1,5‐c]pyrimidine Derivatives
Authors: Ho Yuh‐Wen
Published: May 2015

2,3‐Disubstituted‐pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4(3H)‐ones 8a‐8c, 9a‐9c were obtained by treatment of pyrido[3′,2′:4,5]thieno[3,2‐d][1,3]oxazin‐4(3H)‐one derivative 3,3‐diacetylamino‐thieno[2,3‐b]pyridine derivative 5 and 3‐ethoxymethyleneaminothieno[2,3‐b]pyridine derivative 7a with appropriate amines, respectively. Condensation of compounds 8b, 9b with appropriate α‐chlorocarbonyl compounds gave the corresponding 3‐substituted carbonylmethylene‐pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4(3H)‐one derivatives 13a‐d. 3‐N‐Substituted‐pyrido[3′,2′:4,5]thieno[3,2‐d]pyrimidin‐4(3H)‐ones 15a,b, 16a,b and 18a,b were also obtained by cyclization of carbohydrazide 14 with different reagents under a variety of conditions. On the other hand, cyclization of 3‐amino‐4‐imino‐pyrido[3′,2″:4,5]thieno[3,2‐d]pyrimidin‐4(3H)‐ones 21a,b with appropriate orthoesters afforded the corresponding 3,5‐dialkyl‐pyrido[3′,2′:4,5]thieno[2,3‐e]‐1,2,4‐triazolo[1,5‐c]pyrimidines 22a‐f.