bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation and Functioning of Collaboration Agreement for Intrafamilial Homicide Risk Intervention
Authors: Deslauriers Jean-Martin , Drouin Christine , Higgs Tamsin , Bastonnais Jessica
Published: March 2022

In the worrisome context of increasing rates of intimate partner violence and a number of recent deaths reportedly occurring in domestic situations, the establishment and maintenance of effective intervention strategies is a critical public health concern. The present study aimed to evaluate the functioning of a regional intersectoral rapid intervention collaboration agreement (called A-GIR) initiated to respond preventatively to situations identified as high risk of domestic homicide, in Quebec, Canada. In order to better understand how such a collaboration may be successfully implemented, a qualitative analysis was conducted of the perceived functioning of A-GIR and the factors that favor its success as well as issues that should be addressed in this and other such initiatives to ensure efficient and effective practices that prevent the loss of life. Participants (N = 15) were active A-GIR members, who responded to semi-structured interviews which were thematically analyzed. Results are discussed in relation to established partnership action evaluation criteria. The study highlights the necessary conditions for the success of a collaborative agreement such as A-GIR.
Impacto de las variables paraarancelarias sobre la exportación de fibra de alpaca cardada o peinada peruana hacia la República Popular de China en el Marco del Tratado de Libre Comercio Perú-China durante el periodo 2015 - 2019
Authors:   , Fernandez Costilla Karina Alexandra , Zorrilla Arones Yasmin Liliana
Published: March 2022

Entre los años 2015 - 2019, se observa un cambio constante en el volumen exportado de fibra de alpaca cardada o peinada peruana hacia el mercado chino, la cual no posee una explicación sustentada por una base científica. Es de este modo que se propone investigar y demostrar los factores involucrados de este hecho en el marco del TLC Perú - China, descubriendo que variables no arancelarias como las Disposiciones o Medidas Sanitarias y Fitosanitarias, así como los Obstáculos Técnicos al Comercio; son posibles causantes de esta variación. Además, ambos tienen una influencia significativa en la alteración del precio exportación al que se vende el producto, por lo cual también se toma ello como una variable más. Para ello, la metodología usada para la investigación tiene un enfoque mixto (Cuantitativo y Cualitativo) con un Diseño de Integración Múltiple. La población y muestra es de acuerdo con cada estudio, cuantitativo y cualitativo, siendo la última clasificada como No Probabilística y Muestra de Expertos respectivamente. El instrumento para utilizar para el estudio cualitativo es la entrevista semiestructurada; mientras que para el cuantitativo se usa la investigación documental. La información hallada para ambos casos fue examinada en ATLAS.ti y SPSS de manera correspondiente. Se pudo concluir que las dos primeras variables no tuvieron un impacto negativo en las exportaciones como se expresa en diversos estudios referentes al tema; además de confirmar el involucramiento moderado del precio de exportación en la misma situación, coincidiendo ello con el estudio de referencia para esta variable.
Factores que influyen en el crecimiento del número de franquicias del sector gastronómico peruano en latinoamerica: interculturalidad, negociación internacional y comunicación activa en el periodo del 2013 al 2018
Authors:   , Montalvo Porras Steve Bryam , Torres Vigoria Geraldine Martha
Published: March 2022

La presente investigación tiene como principal objetivo definir, analizar y validar los factores que influyen en el Crecimiento del número de Franquicias del Sector Gastronómico Peruano en Latinoamérica; asimismo este estudio se realiza con el fin de conocer estos factores y realizar una investigación de mercado considerándolos, previamente, si se tiene planeado expandirse internacionalmente bajo el formato de franquicias, y a su vez destacar el sector gastronómico peruano pues, cuenta con gran potencial para llevar su propuesta de valor a países extranjeros. En el primer lugar, se desarrollará el marco teórico en el cual se detallará lo antecedentes sobre el tema estudiado, tanto nacional como internacionalmente; las bases teóricas las cuales ayudarán a entender mejor el tema para desarrollarse en el mundo de las franquicias. Seguidamente, se explicará sobre el plan de investigación a desarrollar, donde se planteará el problema, se establecerá los problemas generales y específicos, así como los objetivos, a su vez se presentarán las hipótesis que se tienen sobre el tema para que luego sean validadas. Luego, se trabajará bajo el enfoque mixto; asimismo, se detallará los instrumentos a utilizar para cada enfoque, pues se aplicarán entrevistas a expertos en el tema de franquicias y a su vez se utilizarán los cuestionarios. Posteriormente, se procesarán los resultados y los objetivos específicos serán contrastados con la información recolectada a través de los instrumentos de investigación y el marco teórico, con el fin de validar las hipótesis planteadas. Y, por último, se presentará las conclusiones y recomendaciones sobre el tema estudiado, con el fin aumentar la expansión a través del formato de franquicias y dinamizar el sector.
Para argumentar, basta começar
Authors: Lopes-Damasio Lúcia Regiane
Published: March 2022

Neste trabalho, com o objetivo de responder à pergunta: quais indícios de natureza linguístico-discursiva podem ser observados entre o funcionamento dos mecanismos de junção e a aquisição da tradição discursiva argumentativa no modo escrito de enunciação?, observo a tradição discursiva argumentativa no contexto de aquisição do modo escrito de enunciar, a partir de uma descrição analítica do funcionamento dos mecanismos de junção, em um espaço teórico construído a partir do diálogo entre os conceitos de tradição discursiva (TD) (KABATEK, 2005); heterogeneidade da escrita (CORRÊA, 2004); aquisição da escrita (LEMOS, 1998); e mecanismos de junção (MJs) (RAIBLE, 2001). Foram analisados 60 textos produzidos por alunos do 1° ao 5° ano do Ensino Fundamental, numa abordagem quantitativo-qualitativa, e alcançados resultados relativos: (i) à descrição da funcionalidade dos MJs, no contexto investigado; (ii) à análise do caráter sintomático dos MJs enquanto marcas da relação oral/falado e letrado/escrito; e (iii) à discussão sobre as relações entre MJs e a aquisição da TD argumentativa na escrita. Tais resultados mostraram que transformação e mudança operam-se no funcionamento simbólico da língua por meio da movimentação, no processo de subjetivação, que, concomitantemente, atinge as formas táticas dessa língua e os sentidos que nela se constituem.
COVID-19 Pandemic: Do Learning Motivation and Learning Self-Efficacy Exist among Higher Vocational College Students?
Authors: Tang Shenlong , Osman Siti Zuraidah Md
Published: March 2022

COVID-19 first appeared in the first quarter of 2020 and spread rapidly throughout the world. Now, schools in China have resumed face-to-face teaching on campus, but the COVID-19 Pandemic still impacts normal teaching activities and student psychology. This quantitative research revealed the levels of learning motivation and learning self-efficacy among higher vocational college students. This study also investigated whether these variables vary according to students' gender, hometown, family structure and field of study. In addition, this research examined the relationship between students' learning motivation and learning self-efficacy. The sample for the survey was 1018 students from a public higher vocational college in Shandong Province. The research collected data via two surveys, the Learning Motivation Scale (LMS) designed by Tian and Pan (2006) and the Learning Self-Efficacy Scale (LSS) designed by Liang (2000). The research used percentages, means, standard deviations, independent group t-test and Pearson correlation coefficient to analyze the data. The results revealed that higher vocational college students' learning motivation and learning self-efficacy scores were above the median score of the two scales. The study found that learning motivation did not vary according to students' gender, field of study or family structure. However, students from different hometowns showed a significant difference in their learning self-efficacy but no significant difference in their learning motivation. Finally, the researchers discovered a significant positive correlation between learning motivation and learning self-efficacy.
Analisis Faktor Perlindungan Konsumen Dalam Urgensi Pembentukan Undang-Undang Pinjaman Online (Peer To Peer Lending)
Authors: Sasmita Helena Toshely , Kamilah Suci , Wardodo Rina Irsni , Wicaksana Thody Daniel Satya Wira
Published: March 2022

AbstractFinancial Technology (Fintech) is currently developing in Indonesia. This is due to the development of increasingly advanced and sophisticated technology and the presence of fintech types of peer-to-peer lending that offer loans easily and quickly. The purpose of this study is to examine and analyze consumer protection factors in the urgency of establishing an online lending law (peer-to-peer lending). This type of research uses normative legal research methods, with a statutory approach and a conceptual approach. Various problems in the use of online loan services (fintech), including in terms of interest rate transparency, misuse of consumer personal data by lending companies, and collection methods that are not following legal rules, while in Indonesia the legal basis for online loan services is only accommodated by POJK No. 77/POJK.01/2016 which has not been able to fully accommodate all aspects of consumer protection such as the mechanism for monitoring online loan services, guarantees for consumer protection for the use of online loan services, and regulations regarding operating permits for fintech peer to peer lending. With the establishment of the online loan law, it is hoped that it will provide legal certainty for consumers in using online loan services today.Keywords: Consumer Protection; Constitution; Financial Technology.AbstrakFinancial Technology (Fintech) saat ini sedang berkembang di indonesia. Hal ini dikarenakan perkembangan teknologi yang semakin maju dan canggih serta kehadiran fintech jenis peer to peer lendingyang menawarkan pinjaman dengan mudah dan cepat. Tujuan penelitian ini adalah untuk mengkaji dan menganalisis faktor-faktor perlindungan konsumen dalam urgensi pembentukan undang-undang pinjaman online (peer to peer lending). Jenis Penelitian ini menggunakan metode penelitian hukum normatif, dengan pendekatan peraturan perundang-undangan (statute approach) dan pendekatan konseptual (conseptual approach). Berbagai permasalahan dalam penggunaan layanan pinjaman online (fintech) diantaranya adalah dari segi transparasi suku bunga, penyalahgunaan data pribadi konsumen oleh perusahaan pemberi pinjaman serta cara penagihan yang tidak sesuai dengan aturan hukum, sedangkan di Indonesia dasar hukum layanan pinjaman online hanya diakomodasi oleh POJK No. 77/POJK.01/2016 yang belum dapat sepenuhnya mengakomodasi seluruh sisi perlindungan konsumen seperti mekanisme pengawasan layanan pinjaman online, jaminan perlindungan konsumen atas penggunaan layanan pinjaman online dan aturan mengenai izin operasi fintech peer to peer lending. Dengan dibentuknya Undang – Undang pinjaman online diharapkan dapat memberikan kepastian hukum bagi konsumen dalam penggunaan layanan pinjaman online saat ini.Kata Kunci: Perlindungan Konsumen; Undang-Undang; Fintech.
Legalitas Perizinan Kawasan Wisata Sebagai Upaya Pengembangan Desa Wisata
Authors: Tjitrawati Aktieva Tri , Amalia Rizky , Hamdan Fairuz Zahirah Zihni
Published: March 2022

AbstractOne of the Government’s efforts to develop the tourism sector is to line up in villages. Some villages that have natural potential have been developed into tourist villages. The development of tourist villages is not only in nature which is the attraction but also can be a means of education that must be optimized. Gerbo Village is one of the villages in the Pasuruan area that seeks to develop its educational tourism. An understanding of the legal aspects, including permits, business contracts, and so on, needs to be given to village officials, tourism awareness groups, and the local community. This goal is intended as a preventive effort to prevent legal problems that may arise in the future.Keywords: Tourism; Villages; Permits; Business Contract.AbstrakSalah satu upaya Pemerintah untuk pengembangan sektor kepariwisataan adalah berlini pada desa. Beberapa desa-desa yang mempunyai potensi alam di kembangkan menjadi desa wisata. Pengembangan desa wisata tidak hanya pada alam yang menjadi daya tarinya, namun juga bisa menjadi sarana edukasi yang harus dioptimalkan, Hal inilah yang dilakukan oleh Desa Gerbo, salah satu desa di kawasan Pasuruan yang berupaya untuk mengembangkan wisata edukasi yang dimiliki. Pemahaman mengenai aspek hukum yang meliputi perizinan, kontrak bisnis, dan sebagainya perlu untuk diberikan bagi perangkat desa, kelompok sadar wisata dan juga masyarakat setempat. Tujuan tersebut diperuntukkan sebagai upaya preventif untuk mencegah problematika-problematika hukum yang kemungkinan timbul di kemudian hari.Kata Kunci: Kepariwisataan; Desa; Perizinan; Kontrak Bisnis.
A generation gap between children and their parents in Pashtun community Buner District, Khyber Pakhtunkhwa, Pakistan
Authors: Wahab Pir , Din Shamas Ud , Pasha Kinan , Ahmed Mukhtar , Hussain Mujahid , Khan Jamil
Published: March 2022

The generation gap is a serious, challengeable problem in the emerging society in Pakistan. It refers to parents or elders’ disagreements, conflicts, inconsistencies, and differences in several matters such as attitude, behaviour, beliefs, values, politics, closeness, modern technology, cultural changes, and communication. The present study was designed to analyse the causes and consequences of the generation gap among the Pashtun community. A quantitative research method was used to select 400 samples of the current population and collect data through a well-designed questionnaire. The validity and reliability of the questionnaire were examined by ten PhD scholars from different universities. The Cronbach’s Alpha for the data is .969. The data was analysed using SPSS version 26. The results were shown in the form of a one-way ANOVA and a frequency distribution table. The data revealed a statistically significant (0.05) relationship between various variables such as technological advancement, living patterns, behaviour, social norms, communication gaps, unemployment, poverty, socioeconomic status, and religiosity. Both parents and children are responsible for the generation gap, but it can be reduced by understanding, loving, caring, sharing, communicating, and maintaining friendly relations.
Sostenibilidad de pequeños productores en Tlaxcala, Puebla y Oaxaca, México
Authors: Bustamante Lara Tzatzil Isela , Carrera Chávez Benjamín , Schwentesius Rindermann Rita
Published: March 2022

La agricultura orgánica es una de las actividades agrícolas con mayor crecimiento. En México, tanto el número de productores como de hectáreas dedicadas a la misma, aumentaron en los últimos años dando oportunidad a los pequeños productores de eliminar parte de la exclusión generada por la agricultura convencional y permitiéndoles ingresar al mercado. Sin embargo, es importante conocer la situación de estos productores desde diversas ópticas, por lo que en este trabajo se llevó a cabo la medición de su sostenibilidad económica, ecológica y socio-cultural con el fin de mostrar que su inclusión en tianguis y mercados orgánicos les permite sostenibilidad. Para esto, se seleccionaron tres mercados de la Red Mexicana de Tianguis y Mercados Orgánicos en los estados de Tlaxcala, Puebla y Oaxaca. Se aplicaron 30 encuestas y, los datos se agruparon en escalas de 0 a 4 indicando menor y mayor sostenibilidad respectivamente, (valores arriba de 2, implican sostenibilidad). Estos indicadores se ponderaron según su importancia. Los resultados muestran que los pequeños productores de estos tianguis son sostenibles económica y ecológicamente puesto que los valores arrojados por los indicadores fueron 2.62 y 2.5 respectivamente, sin embargo, en el criterio socio-cultural el resultado fue de 1.77 es decir, no sostenible. Por lo tanto se requiere llevar a cabo estrategias que mejoren el valor de estos indicadores a través de la promoción y difusión de productos orgánicos y el mercado local, concientización sobre las prácticas ecológicas y sus procesos y, la participación de más actores involucrados en esta práctica agrícola.
Supplementary methods for "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress"
Authors: Bonagas Nadilly , Gustafsson Nina , Henriksson Martin , Marttila Petra , Gustafsson Robert , Wiita Elisée , Borhade Sanjay , Green Alanna , Vallin Karl , Sarno Antonio , Svensson Richard , Göktürk Camilla , Pham Therese , Jemth Ann-Sofie , Loseva Olga , Cookson Victoria , Kiweler Nicole , Sandberg Lars , Rasti Azita , Unterlass Judith , Haraldsson Martin , Andersson Yasmin , Scaletti Emma , Bengtsson Christoffer , Paulin Cynthia , Sanjiv Kumar , Abdurakhmanov Eldar , Pudelko Linda , Kunz Ben , Desroses Matthieu , Iliev Petar , Färnegårdh Katarina , Krämer Andreas , Garg Neeraj , Michel Maurice , Häggblad Sara , Jarvius Malin , Kalderén Christina , Jensen Amanda Bögedahl , Almlöf Ingrid , Karsten Stella , Zhang Si Min , Häggblad Maria , Eriksson Anders , Liu Jianping , Glinghammar Björn , Nekhotiaeva Natalia , Klingegård Fredrik , Koolmeister Tobias , Martens Ulf , Llona-Minguez Sabin , Moulson Ruth , Nordström Helena , Parrow Vendela , Dahllund Leif , Sjöberg Birger , Vargas Irene , Vo Duy Duc , Wannberg Johan , Knapp Stefan , Krokan Hans , Arvidsson Per , Scobie Martin , Meiser Johannes , Stenmark Pål , Berglund Ulrika Warpman , Homan Evert , Helleday Thomas
Published: March 2022

Supplementary methods for the article "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress".
Identifying Youth with Anxiety Disorders in Pediatric Primary Care Setting: A Preliminary Report from Thailand
Authors: Ularntinon Sirirat , Nithiuthai Jinjutha
Published: March 2022

Background: Non-specific somatic symptoms are common chief complaints among the youths who have anxiety disorders, particularly in non-Western countries where childhood mental health needs are under-recognized. Screening for the youths at risk of anxiety disorders in pediatric medical setting, then can be an ample opportunity to identify this most prevalent but under-diagnosed mental health problem. Therefore, this study aims to determine the possibility of identifying the youths at risk of having anxiety disorders who visited a pediatric primary care clinic for the examination of physical symptoms in Thailand.Methods: The Screen for Child Anxiety and Related Emotional Disorders (SCARED - Thai Version), including youth self-report and parent forms, were completed by 92 pairs of youths andtheir parents. Data regarding associated factors, clinical characteristics, and general health status in the past year were obtained. Results: Anxiety disorder symptoms above the threshold for clinical diagnosis of the SCARED were identified in 39% of participants. Clinical variables associated with significantly elevated anxiety symptoms included female gender, having non-specific somatic pain as main complaints, and a number of medical visits greater than 6 times in the past year.Conclusions: Anxiety disorder in youths is frequently under-diagnosed and un-treated, hence, becoming a hidden burden in pediatric medical setting in non-Western countries where mental health movement is still evolving. Enhancing awareness of the possibility of anxiety disorder in the youths presenting with unexplained physical complaints is a crucial step toward reducing this load of unnecessary medical health care utilization and optimizing long-term outcomes of the affected youths.
Level IV neck dissection in cN0 HPV-negative oropharyngeal squamous cell carcinoma: A retrospective cohort study
Authors: Huo Zirong , Fu Shuiting , Ma Chunyue , Sheng Surui
Published: March 2022

Background: As opposed to observation of the neck, elective neck dissection has a survival benefit for cN0 oropharyngeal squamous cell carcinoma (OPSCC). However, there are limited date on level IV neck dissection in human papillomavirus (HPV)-negative OPSCC because most earlier studies did not stratify by P16 or HPV status. Thus, whether to exclude level IV from selective dissection (SND) of cN0 HPV-negative OPSCC remains controversial. Methods: In this single-center retrospective cohort study, disease-free survival (DFS) was estimated as the primary endpoint for 124 cN0 HPV-negative OPSCC patients who received SND of levels I-III (Group A) and I-IV (Group B). Overall survival (OS) and disease-specific survival (DSS) were considered secondary endpoints.Results: For the entire cohort, the 5-year DFS rates of Groups A and B were 55.0% and 60.1%, respectively. Five-year OS rates were 58.9% and 61.5%, and 5-year DSS rates were 74.0% and 64.8%, respectively. Group B did not show higher 5-year DFS, OS, or DSS than Group A.Conclusions: This retrospective cohort study validated that in cN0 HPV-negative OPSCC, SND including level IV does not have substantial benefits regarding DFS, OS or DSS.
Development of SSR markers and genetic diversity evaluation of Mycocentrospora acerina causing round spot of Panax notoginseng in Yunan province, China
Authors: He Xiahong , Wang Huiling , Yang Kuan , Guo Liwei , Luo Lifen , He Chi , Li Xiang , Liu Yixiang , Huang Huichuan , Yang Min , Zhu Shusheng , Zhu Youyong
Published: March 2022

Background: Sanqi round spot, which is caused by Mycocentrospora acerina, is a destructive disease limits the production of Panax notoginseng in Yunnan province of China. However, the disease has not been studied comprehensively. Results: In the current study, we identify M. acerina polymorphic microsatellite markers using CERVUS 3.0 and compare the genetic diversity of its isolates from P. notoginseng round spot using Simple Sequence Repeat (SSR) markers and polyacrylamide gel electrophoresis. Thirty-two SSR markers with good polymorphism were developed using MISA and CERVUS 3.0. The genetic diversity of 187 M. acerina isolates were evaluated using 14 representative SSR primers, and the polymorphic information content values of 14 sites ranged from 0.813 to 0.946, with a total of 264 alleles detected at 14 microsatellite loci. The average expected heterozygosity was 0.8967. Conclusion: 14 SSR primers of M.acerina can be used in diversity analysis and identification of M. acerina and its closely related species. Genetic diversity of M. acerina in Yunnan province does not reflect geographic specificity.
The Applicability of eVTOLs in Emergency Medical Care in Japan
Authors: Nakamoto Aki , Mihara Yusuke , Motomura Tomokazu , Matsumoto Hisashi , Nakano Masaru
Published: March 2022

Background: The present study aims to elucidate the applicability of electric vertical takeoff and landing (eVTOL) aircraft that dispatch only a doctor to provide a solution to the operational challenges of utilizing a helicopter to transport a doctor to the patient/s, with such physician-staffed emergency medical helicopters being known as doctor heli (DH), in Japan.Methods: This study conducted interviews with 17 parties related to DHs in five prefectures in Japan to depict challenges of DHs and eVTOL requirements. Subsequently, this study analyzed the Hokusoh DH flight data, as an example, in terms of cases for which flight doctors consider condition assessment and initial treatment provision by a doctor would be particularly effective, to assess the hypothesis that a two-seater is applicable for emergency medical care (EMS) and that eVTOLs help reduce duplicate dispatch requests for DHs as well as the percentage and delayed dispatch time of duplicate requests.Results: Challenges of DHs and eVTOL requirements were identified and classified into six major categories. Data analysis results indicated that two-seater eVTOLs would be particularly effective for trauma, cardiac disease, brain disease cases, and pediatric patient cases and help solve duplicate requests.Conclusions: Two-seater eVTOLs are likely applicable in EMS in Japan.
Assessment of Type I Interferon Signatures in Undifferentiated Inflammatory Diseases: A Japanese Multicenter Experience
Authors: Miyamoto Takayuki , Honda Yoshitaka , Izawa Kazushi , Kanazawa Nobuo , Kadowaki Saori , Ohnishi Hidenori , Fujimoto Masakazu , Kambe Naotomo , Kase Naoya , Shiba Takeshi , Nakagishi Yasuo , Akizuki Shuji , Murakami Kosaku , Bamba Masahiro , Nishida Yutaka , Inui Ayano , Fujisawa Tomoo , Nishida Daisuke , Iwata Naomi , Otsubo Yoshikazu , Ishimori Shingo , Nishikori Momoko , Tanizawa Kiminobu , Nakamura Tomoyuki , Ueda Takeshi , Ohwada Yoko , Tsuyusaki Yu , Shimizu Masaki , Ebato Takasuke , Iwao Kousho , Kubo Akiharu , Kawai Toshinao , Matsubayashi Tadashi , Miyazaki Tatsuhiko , Kanayama Tomohiro , Isa-Nishitani Masahiko , Nihira Hiroshi , Abe Junya , Tanaka Takayuki , Hiejima Eitaro , Okada Satoshi , Ohara Osamu , Saito Megumu K , Takita Junko , Nishikomori Ryuta , Yasumi Takahiro
Published: March 2022

PurposeUpregulation of type I interferon (IFN) signaling has been increasingly detected in inflammatory diseases. Recently, upregulated IFN signature has been suggested as a potential biomarker to identify IFN-driven inflammatory diseases. Yet, it remains unclear to what extent type Ⅰ IFN is involved in the pathogenesis of undifferentiated inflammatory diseases. This study aimed to quantify the type Ⅰ IFN signature in clinically undiagnosed patients and assess clinical characteristics in those with a high IFN signature. Methods A type Ⅰ IFN signature was measured in patients’ whole blood cells. Clinical and biological data were collected retrospectively, and an intensive genetic analysis was performed in undiagnosed patients with a high IFN signature.ResultsA total of 113 samples from 94 patients with inflammatory diseases, including 37 undiagnosed cases, were analyzed. Increased IFN signaling was observed in 19 undiagnosed patients, with ten exhibiting clinical features commonly found in type Ⅰ interferonopathies. Skin manifestations, observed in eight patients, were macroscopically and histologically similar to those found in proteasome-associated autoinflammatory syndrome. Genetic analysis identified novel mutations in the PSMB8 gene of one patient, and rare variants of unknown significance, in genes linked to type Ⅰ IFN signaling, in four patients. A JAK inhibitor effectively treated the patient with the PSMB8 mutations. Patients with clinically quiescent idiopathic pulmonary hemosiderosis and A20 haploinsufficiency showed enhanced IFN signaling.ConclusionsHalf of the patients examined in this study, with undifferentiated inflammatory diseases, clinically quiescent A20 haploinsufficiency, or idiopathic pulmonary hemosiderosis, had an elevated type Ⅰ IFN signature.
Accuracy of SCORTEN in predicting mortality
Authors: Strużyna Jerzy , Surowiecka Agnieszka , Korzeniowski Tomasz , Korulczyk Patrycja , Drozd Lukasz , Stachura Aldona , Torres Kamil , Krajewski Andrzej
Published: March 2022

BackgroundTEN patients require multi-directional and multi-disciplinary treatment. In most cases, they are hospitalised at intensive care units and require multi-directional, burn-complication preventive care. Choosing the most appropriate treatment option might be troublesome even when predicting scores are used. SCORTEN is the most renowned prognostic score for TEN patients, however, there are some data indicating that the accuracy of this test may be limited. The credibility of not just the predicted mortality risk, but also componential laboratory results and clinical features subject to debate. The aim of this study was to evaluate the efficacy and credibility of SCORTEN in clinical practice, on proprietary material. Methods: A retrospective analysis of 35 patients with diagnosed in histopathology TEN was performed. The inclusion criteria were as follows: day of submission before 5th day from the onset of the symptoms, full protocol of plasmaphereses and IVIGs according to our scheme.Results:The sensitivity of SCORTEN for the analysed cohort was 100%, with a specificity of 24%. The estimated death was 41,9%, while the actual death rates were 12,5%. Our protocol improved the survival, OR=26,57, RR=6,34, p=0,022. Decrease in mortality was caused by a combined treatment protocol we use- plasmaphereses with IVIGs. No independent risk factor was significant in death evaluation. Conclusions:Our data suggest that the scoring system for predicting death among TEN patients are reliable when they are high. New prognostic factors should be found to improve the evaluation of patients with low SCORTEN.
Obtaining A Unified Picture of Heterogeneous and Homogeneous Crystallization with Kinetic Transition Rate
Authors: Chen Zhen , Xu Lei
Published: March 2022

Heterogeneous and homogeneous crystallization exhibit distinct phase transition kinetics. However, due to the difficulty of realizing both heterogeneous and homogeneous crystallization under an identical thermodynamic condition, an independent comparison of the two remains lacking. In this work, we experimentally realize a continuous tuning from heterogeneous to homogeneous crystallization under an identical thermodynamic condition, capture the entire colloidal crystallization process of each particle, and discover a universal picture of the two modes. In the heterogeneous crystallization regime, we reveal an unexpected variation of critical nucleus size with boundary disorderness instead of contact angle, which violates the classical nucleation theory but enables the system tuning. Moreover, analogous to reaction rates in chemical reactions, we propose and measure the kinetic transition rates of crystallization, which quantify the transition probabilities between any two intermediate structures. To our surprise, regardless of heterogeneous or homogeneous crystallization, all 42 kinetic transition rates fall onto universal master curves, which unifies the two distinct crystallization modes into a universal picture.
P-selectin in pregnant women with vein thrombosis and compare the predictive value of this biomarker with Wells criteria
Authors: tabrizian shervin , ghobadi hasan , khorrami yadollah , rostamnejhad masoomeh , safarzadeh elham , matin somaieh
Published: March 2022

Background: The diagnosis of venous thromboembolism (VTE) during pregnancy is a challenging task. Due to its naturally high level during pregnancy, D-Dimer concentration is not reliable diagnostic. P-selectin is another diagnostic biomarker that can aid the diagnosis of VTE. In the present study, an attempt was made to determine the relationship between P-selectin and acute VTE in pregnant women and compare it’s predictive value with Wells criteria.Materials and methods: In this case-control study, 29 pregnant women with pulmonary thromboembolism (PTE), 33 pregnant women with deep vein thrombosis (DVT), and 32 matched healthy pregnant women were investigated. After obtaining informed written consent, 3 cc of venous blood sample was taken from each of the participants. The samples were then assessed for P-selectin and D-Dimer concentrations via the use of ELISA tests. Finally, statistical analyses were performed. Findings: Significant differences were observed between all of the groups under investigation in terms of both mean P-selectin and mean D-Dimer concentrations (P<0.05). The mean P-selectin concentration in patients with high Wells score was significantly higher than that of the patients with moderate and low Wells score (P<0.05). Moreover, week positive correlation was observed between P-selectin and D-Dimer concentrations (r=0.3, P=0.003). Logistic regression also revealed that both P-selectin and D-dimer were predictive factors of thrombosis in pregnant women. Conclusion: The increase in P-selectin concentration during pregnancy is associated with high incidence of VTE. Compared with D-Dimer, P-selectin is a predictor of thrombosis, especially in patients with high clinical probability based on Wells score.
A Reexamination of How National Culture Influences Environmental Performance: Based on Neo-Configurational Perspective
Authors: Xu Ting , Chen Di , Lv Zhike
Published: March 2022

The inconsistencies and conflicts in the relationship between national culture and environmental performance imply the need for more fine-grained research. Our study advanced existing research by identifying the configurational effect of the six cultural dimensions that lead to high or low environmental performance with the support of the fuzzy-set Qualitative Comparative Analysis (fsQCA). Our results demonstrate that there is no national recognized as a necessary condition for high environmental performance, but high power distance and collectivism are identified as necessary conditions for low environmental performance. And we also summarize four configurations leading to high environmental performance and one configuration leading to low environmental performance. This study contributes to the field of cultural factors and environmental performance from the perspective of method and content.
Birt-Hogg-Dubé Syndrome Encountered At Rare Lung Disease Clinic In Anhui Province, China
Authors: Zhang Guofeng , Liu Jinli , Wang Yushuo , Wang Yue , Jiang Xianliang , Peng Yan , Xiao Jun , Wei Wei , Shen Bing , Yi Long , Ryu Jay H. , Hu Xiaowen
Published: March 2022

Background: Diagnosis of rare diseases remains a challenge in China. We describe our experience with Birt-Hogg-Dubé syndrome (BHDS) encountered at a Rare Lung Disease Clinic recently established in China.Methods: After the first patient with BHDS was recognized in 2017, a Rare Lung Disease Clinic with a multidisciplinary team of specialists was established. We retrospectively analyzed the data of consecutive patients with BHDS encountered from inception to December 2021.Results: There were 1, 1, 15, 12 and 21 cases with BHDS diagnosed from year 2017 to 2021, respectively. All 50 patients (34 women) were of Han race with a mean age of 47.3 years. The common manifestations were pulmonary cysts (98%), pneumothorax (54%) and skin lesions (68%). Renal cancer was detected in two patients and renal angiomyolipoma in four other patients. The main presentations leading to diagnosis were pneumothorax (42%), family screening (36%) and lung cysts identified on radiologic imaging (20%). The average delay in diagnosis was 8.3 years, and 4.7 years in patients with only pulmonary cysts. The most frequent pathogenic variant was c.1285del/dup on exon 11 (23%) among 44 patients confirmed by genetic testing. Renal cancer has not been found on follow-up surveillance thus far.Conclusions: There has been increasing number of patients with BHDS recognized in China, facilitated by establishment of a Rare Lung Disease Clinic. Pulmonary cysts and pneumothorax were commonly encountered features, but skin lesions appeared to be more prevalent in Chinese subjects than previously reported in other Asian countries.
Introduced Galliforms As Seed Predators And Dispersers In Hawaiian Forests
Authors: Case Samuel , Postelli Katherine , Drake Donald R. , Vizentin-Bugoni Jeferson , Foster Jeffrey T. , Sperry Jinelle H. , Kelley J. Patrick , Tarwater Corey E.
Published: March 2022

In altered communities, novel species’ interactions may critically impact ecosystem functioning. One key ecosystem process, seed dispersal, often requires mutualistic interactions between frugivores and fruiting plants, and functional traits, such as seed width, may affect interaction outcomes. Forests of the Hawaiian Islands have experienced high species turnover, and introduced galliforms, the largest of the extant avian frugivores, consume fruit from both native and non-native plants. We investigated the impact of two galliform species on seed dispersal processes in Hawaiian forests. Using captive Kalij Pheasants (Lophura leucomelanos) and Erckel’s Francolins (Pternistis erckelii), we measured the probability of seed survival during gut passage and seed germination following gut passage. We also examined which seeds are being dispersed in forests on the islands of O‘ahu and Hawai‘i. We found that galliforms are major seed predators for both native and non-native plants, with less than 5% of seeds surviving gut passage for all plants tested and in both bird species. Gut passage by Kalij Pheasants significantly reduced the probability of seeds germinating, especially for the native plants. Further, larger-seeded plants were both less likely to survive gut passage and to germinate. In the wild, galliforms dispersed native and non-native seeds at similar rates. Overall, our results suggest the introduced galliforms are a double-edged sword in conservation efforts; they may help reduce the spread of non-native plants, but they also reduce seed dispersal of native plants. Broadly, we show mutualism breakdown may occur following high species turnover, and that functional traits can be useful for predicting outcomes from novel species’ interactions.
Impairment Strained Analytical Modeling Evaluation and Cross-talk Analysis of Symmetric and Coexistent Channels for Extended Class-1 NG-PON2 Access Network
Authors: Pagare Rajendraprasad , Mishra Abhilasha , Kumar Santosh
Published: March 2022

The analytical modeling for channel linear and non-linear impairments (LNI) and simulative analysis of extended power budget class-1 i.e. E1-class of next generation passive optic network-2 (NG-PON2) delivering symmetric 2.5 point-to-multi point (PtM) representing time and wavelength division multiplexing (TWDM) XGS-PON along with 10 Gbps point-to-point (PtP) wavelength division multiplexing (WDM) symmetric and coexistent channels in worst-case scenario is presented in the paper. Channel modelling of LNI is carried out under the incremental and aggregate strain of estimated chromatic dispersion CD, selfphase modulation (SPM), cross-phase modulation (XPM) of single mode fiber (SMF) channel deployed in optical distributing network (ODN) between 20 – 50 km link lengths. Downlink (D/L) and uplink (U/L) ODN is optimized to PTODN = 7.1 dBm and 4.09 dBm respectively and corresponding channel imparities including Kerr parameter γ, corresponding SPM, XPM, CD, four-wave mixing (FWM) analysis and corresponding component power and efficiency, interchange crosstalk (Cc) attracting power penalties (Pc) are estimated and incorporated in the simulation for the real response of lossy SMF channel. Further, splitter power budget (SP) and slitter configuration for respective PtM and PtP D/L channels are estimated under the aggregate impact of CD, SPM, XPM and FWM. Analytical modeling of LNI and simulative analysis has confirmed the configuration delivered rise in receiver sensitivity (Rxs) of -39.75/-33.45 dBm and -29/-35.34 dBm for D/L and U/L channels respectively. The estimated power of FWM element is between 1.34x10-52 to 2.15x10-53 and 3.87x10-52 to 2.41x10-51 contributing crosstalk between channels (Cc) of -31.97/-30.12 dB for down/up spectrum under the impact of SPM and XPM respectively accommodating splitter configuration of 768 at 40 km.
Wellness on Wheels (WoW): Iterative evaluation and refinement of mobile computer-assisted chest x-ray screening for TB improves efficiency, yield, and outcomes in Nigeria
Authors: Mitchell Ellen , Abdur-Razzaq Hussien , Anyebe Victor , Lawanson Adebola , Onyemaechi Simeon , Chukwueme Nkemdilim , Scholten Jerod , Nongo Debby , Ogbudebe Chidubem , Aboki Danjuma , Dimkpa Chimezie , Egbule Daniel , Nsa Bassey , Eneogu Rupert , Grinten Emmy van der , Useni Sani , Festus O. Soyinka , Nwadike Peter , Gidado Mustapha , Ubochioma Emperor
Published: March 2022

Background: Wellness on Wheels (WoW) is a model of mobile systematic TB screening of high-risk populations combining digital chest radiography with computer-aided automated interpretation and chronic cough screening to identify presumptive TB in communities, health facilities and prisons in Nigeria. Understanding how models are designed and refined over time helps others to anticipate technical and political challenges, replicate successful strategies, and avoid common mistakes.Methods: We piloted and refined approaches in phased evaluations, recalibrating CAD4TB thresholds to balance TB yield and feasibility. Iterative data monitoring of screening volumes, risk mix, number needed to screen (NNS), number needed to test (NNT), sample loss, TB treatment initiation and outcomes. Risk factors for loss along the diagnostic cascade were identified and mitigation plans were implemented. Participants with high likelihood on CAD4TB (≥80) who tested negative on a single spot GeneXpert were followed-up.Results: Gradual improvements included: achieving screening targets (64.0% to 70.5%), risk group inclusion (91.5% to 92.9%), on-site sample processing (84.3% to 86.1%), treatment initiation (86.7% to 90.8%), treatment success (70.6% to 83.2%), and NNT (8.2 to 7.6). However, expectoration by asymptomatic presumptive participants (≈85%) and HIV testing coverage (64.9%) remained suboptimal.Conclusion: Mobile computer-assisted digital chest x-ray and chronic cough screening with GeneXpert MTB/RIF testing is feasible, acceptable, efficient and high-yield when highest risk groups and key stakeholders are engaged, and operations evolve in real time to fix problems. CAD4TB scores should be used to identify people who need clinical diagnosis and/or longer-term follow-up for progression to TB disease.
An Investigation Into the Conjunctival and Nasal Flora of Patients Receiving Cyclosporine Eye Drop Treatment for Dry Eye
Authors: elibol Emine Savran , habip Zafer , Elbay Ahmet , Cırık Ahmet adnan , Oğuz Halit
Published: March 2022

OBJECTIVEThe aim of this study is to analyze the long-term use of cyclosporine drops of anti-inflammatory effect on conjunctival and nasal flora, which are commonly used in dry eye treatment, , to examine antibiotic resistance and to suggest some precautions.METHODSThe 38 people using cyclosporine drops were classified as Group 1, and the 34 people using preservative-free artificial tear preparations were classified as Group 2. Swabs were taken from the conjunctiva and nasal cavities of the volunteers participating in the study and cultured. Groups 1 and 2 were compared in terms of growing microorganisms and antibiotic susceptibility.RESULTSThere was no statistically significant difference between Groups 1 and 2 in terms of bacteria growing in the eye and nasal cavities. When it comes to the antibiotic susceptibility statistics for S. epidermidis, low sensitivity to penicillin was observed in particular in both groups, but there was no significant difference between the two groups (p=0.036)CONCLUSIONThe use of cyclosporine or preservative-free artificial tears did not make any difference to the flora or to the antibiotic susceptibility of the flora. It is thought that the use of cyclosporine drops does not predispose to ocular infection.
Aptasensor Based on Screen-Printed Carbon Electrodes Modified with Aunps/CS for Sensitive Detection of Okadaic Acid in Shellfish
Authors: Dong Yiyang , Zeng Ni , Yang Yan , Yin Yingai , Zhao Lianhui , Wang Xu
Published: March 2022

Objective
Based on the specific binding of target with aptamer, a portable aptasensor combined with highly sensitive electrochemical methods was designed to complete the rapid detection of biological toxins Okadaic acid (OA) in shellfish.
Results
A simple aptasensor based on screen-printed carbon electrode (SPCE) with modification of chitosan (CS) and gold nanoparticles (AuNPs) was designed for electrochemical determination of OA, and the electrode surface was modified with AuNPs by potential-sweeping electrodeposition, which greatly improved the electrochemical response. The entire detection and characterization process were carried out by cyclic voltammetry (CV) with a linear correlation in the range from 0.01 ng/mL to 100 ng/mL and a LOD of 6.7 pg/mL. Furthermore, a recovery rate of 92.30-115.98% was obtained demonstrating excellent accuracy through the recovery trial of mussel and scallop samples.
Conclusion
The current method based the change of spatial structure before and after aptamer binding target showed great potential in rapid on-site and low-cost detection of OA for its simplicity.
Posterior Tibial Slope and Medial Tibial Depth Measured by MRI in Patients with Posterior Cruciate Ligament Injury: A Case-Control Study
Authors: Zhou Aiguo , Yin Baoshan , Zhao Pei , Chen Jiaxing , Yan Wenlong , Zhang Hua , Zhang Jian
Published: March 2022

Objectives To 1) figure out the difference in tibial morphologies between patients with posterior cruciate ligament (PCL) injury and those without, 2) identify any tibial anatomical variations contributing to PCL rupture.Design Retrospective case-control study, level of evidence III.Methods 45 patients with PCL rupture from 2015 to 2020 in our hospital, and 45 patients matched by age and sex with intact PCL were enrolled in our study. The intraclass correlation coefficient (ICC) was used to assess the reliability of each parameter. The independent t-test was conducted to identify the differences in tibial morphometric characteristics between the PCL-injured and PCL-intact individuals, including the posterior tibial slope (PTS), meniscal slope (MS), medial tibial depth (MTD). A binary logistic regression model was established to evaluate the roles of those anatomic parameters of interest play in PCL injuries. Results The interobserver reliability of each parameter showed excellent agreement. Significant differences in the medial (P= .023) and lateral (P= .009) PTS were found between the PCL-injured group (3.68 ± 2.70 and 4.55 ± 3.19, respectively) and the controls (5.00 ± 2.73 and 6.39 ± 3.29, respectively). And the MTD was 1.98 ± 0.64 mm in the PCL-injured group and 2.37 ± 0.55 mm in the control group (P=0.007). Binary logistic regression analysis showed that smaller lateral PTS and MTD were directly associated with PCL injury, with an OR of 1.17 and OR of 3.14, respectively. The medial PTS was independent to PCL injures.Conclusion In patients with PCL injury, lateral PTS, medial PTS, and MTD were found smaller compared to PCL intact controls. Decreased lateral PTS and MTD were underlying anatomic risk factors for PCL injury, with each unit reduction, the risks of PCL injury were 1.2 and 3.1-fold higher, respectively.
Elongated soy protein isolate-poly(D, L-lactide-co-glycolic acid) microcapsules prepared using syringe filters and their effect on self-healing efficiency of soy protein-based green resin
Authors: Shi Shanshan , Netravali Anil
Published: March 2022

A self-healing soy-based resin filled with soy protein isolate (SPI) containing poly(D, L-lactide-co-glycolic acid) (PLGA) microcapsules (MCs) was prepared. MCs were prepared using a syringe filter via a membrane emulsification technique. Using this method, spherical (diameter of about 1.30 μm) and elongated MCs (aspect ratios up to 20) could be produced. Tensile properties and self-healing efficiencies of resins were characterized for both MC morphologies in terms of strength recovery and toughness recovery. While both MCs could successfully heal cracks, spherical MCs were seen to compromise the tensile properties of the resin, whereas elongated MCs demonstrated some mechanical enhancement. Overall results showed that elongated MCs having a higher aspect ratio resulted in slightly better self-healing performance as well as a mechanical improvement. The results also show that higher MC loading results in higher self-healing efficiency.