bluuebunny/crossref_metadata_2025 huggingface dataset:
Epimedium/Icariin promotes angiogenesis through HIF-1 signaling pathway
Authors: Song Chao , Jiang Yingcun , Cai Weiye , Cheng Kang , Chen Rui , Qiu Junjie , Hao Qi , Liu Zongchao
Published: April 2023

Objective, With the help of network pharmacology and in vitro studies, this study aims to understand the mechanism by which Epimedium/ Icariin (EPI/ICA) promote angiogenesis through the HIF-1 signaling pathway, laying the groundwork for the treatment of bone discontinuity.
Methods, 1) The TCMSP database provided the gene targets for Epimedium's effect in this investigation. Search the GeneCards database for gene targets associated with "bone discontinuity". GO, KEGG, and Reactome enrichment analysis is performed after identifying possible gene targets for EPI/ICA treatment of bone discontinuity. Molecular docking to confirm the HIF-1 pathway's essential proteins' capacity to bind to ICA. 2) ①. Human umbilical vein vascular endothelial cells (HUVECs) were divided into blank control groups and ICA groups with different concentrations (0.01, 0.1, 1, 10 mol/L), and CCK8 measured the proliferative activity of HUVECs in each group after ICA intervention. These in vitro experiments sought to identify the optimal intervention concentration of ICA. ②. A test for angiogenesis to determine whether it can encourage angiogenesis. ③. After ICA intervention, Western blot and Elisa measured the level of HIF-1 pathway-related protein activity in each group.
Results, For the treatment of bone discontinuity, the bioinformatic analysis of EPI/ICA identified 164 potential therapeutic gene targets, including 45 important gene targets and 10 of these crucial gene targets (HIF1A, AKT1, TPT3, IL6, TNF, VEGFA, CASP3, MYC, EGFR, ESR1). The biological mechanisms examined in the GO of EPI/ICA for the treatment of osteonecrosis act primarily through the regulation of angiogenesis and the negative regulation of apoptotic processes, according to enrichment analysis of 45 important gene targets. The HIF-1 signaling pathway, TNF signaling pathway, IL-17 signaling pathway, and other signaling pathways were found to be primarily involved in the regulation of the EPI/ICA process in the therapy of bone discontinuity, according to KEGG analysis. Reactome enrichment analysis showed that the regulation of the EPI/ICA treatment of bone discontinuity mostly involves the regulation of inflammatory factors that are similar to interleukin and the body's autoimmune system. According to the results of molecular docking, ICA binds efficiently to the important target proteins of the HIF-1 signaling pathway, HIF-1A, VEGF, and IL-6. Further research revealed that ICA, the active ingredient in Epimedium, might increase the value-added differentiation of HUVECs, with the potential mechanism being angiogenesis via the HIF-1 signaling pathway.
Conclusion: This research revealed that EPI/ICA controls HIF-1A, VEGF, and IL-6, which are important HIF-1 signaling pathway target proteins, increases the value-added differentiation of HUVECs and angiogenesis, and offers a new approach for the treatment of bone discontinuity using EPI/ICA.
Discovery of a trace fossil containing the remains of miniscule squamates and the feathered arm of a tiny bird-like therapod
Authors: Smith John
Published: April 2023

Micropaleontology is the study of microscopic fossils such as coccoliths, foraminifera, diatoms, radiolaria, and pollens. These diminutive fossils range in size from 0.001 to 1 mm and are the most abundant and ancient of Earth’s fossils1. I now report the finding of a colony of tiny squamates ranging in size from 0.13 to 10.0 mm (snout-to-vent length) on a Cretaceous period trace fossil from Hamblen County, Tennessee. The dorsal (older) surface contains the remains of a miniscule saurian neonate (prop. M. hamblensis) and three juvenile saurians undergoing body elongation and limb reduction, findings in keeping with a lizard-to-snake transformation2. The ventral surface contains the remains of a colony of tiny snakes including 4 birthing rookeries with egg embryos. Also found is the feathered arm of a tiny bird-like therapod.
A Comparison of Conventional and Accelerated Corneal Crosslinking: Corneal Epithelial Remodeling and In Vivo Confocal Microscopy Analysis
Authors: Hacıağaoğlu Sezer , Turhan Semra Akkaya , Toker Ebru
Published: April 2023

Purpose
To evaluate the effect of conventional and accelerated corneal crosslinking (CXL) on visual acuity, corneal topography, corneal epithelial thickness, and subbasal nerve morphology in progressive keratoconus patients.
Methods
In this prospective and randomized study, twenty eyes of 20 patients were treated with conventional CXL (3mW/cm2, 30 minutes, C-CXL) and 19 eyes of 19 patients were treated with accelerated CXL (9 mW/cm2, 10 minutes, A-CXL). The spherical equivalent (SE), uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), keratometric measurements, demarcation line measurement and epithelial thickness mapping analyses, and subbasal nerve morphology with in vivo confocal microscopy (IVCCM) were evaluated at baseline and at postoperative months 1, 3 and 6.
Results
At postoperative 6 months, a significant improvement was observed in all keratometric values in both treatment groups (p < 0.05). All epithelial thickness indices, except central, temporal, and inferotemporal thickness, were reduced at 1 month postoperatively in both treatment groups. The epithelial map uniformity indices (standard deviation and difference between min-max thickness) were significantly lower than the baseline values at all time points after CXL in both treatment groups (p < 0.001). Compared with the preoperative values, there was a significant decrease in all IVCCM parameters at 1 month postoperatively (p < 0.05). At 6 months postoperatively, corneal nerve fiber density and corneal nerve branch density recovered to preoperative values in the A-CXL group, whereas corneal nerve regeneration was not complete in the C-CXL group.
Conclusion
Both conventional and accelerated CXL treatments appear to be effective in halting the progression of KC. Corneal epithelial irregularity slightly improves after CXL. The regeneration of subbasal nerves is faster after A- CXL treatment.
Expression of Galecitn-9 in colorectal cancer and its clinical significance
Authors: shao wenzhe , sun qiannan , sun guowei , fu yayan , ma yue , ren jun , wang daorong
Published: April 2023

Colorectal cancer is a crucial health-threatening problem. In recent years, the treatment of colorectal cancer has continued improved and update. But the prognosis of advanced colorectal cancer is still disappointing. Galecitn-9 is a member of the galectin family which has been verified to have multiple biological regulatory functions. Our team has been studying the clinical application of the galectin family in gastric and colorectal cancer. However, we do not yet unveil the correlation between Galecitn-9 and colorectal cancer. This study aimed to elucidate the expression of Galecitn-9 in colorectal cancer and the effect of Galecitn-9 on colorectal cancer proliferation, migration and invasion.
hyOPTGB: An Efficient OPTUNA Hyperparameter Optimization Framework for Hepatitis C Virus (HCV) Disease Prediction in Egypt
Authors: Elshewey Ahmed M.
Published: April 2023

The paper focuses on Hepatitis C Virus (HCV) infection in Egypt, which has one of the highest rates of HCV in the world. The high prevalence is linked to several factors, including the use of injection drugs, poor sterilization practices in medical facilities, and low public awareness. This paper introduces a model called hyOPTGB, which employs an optimized gradient boosting (GB) classifier to predict HCV disease in Egypt. The model's accuracy is enhanced by optimizing hyperparameters with the OPTUNA framework. Min-Max normalization is used as preprocessing step for scaling the dataset values and also, using the forward selection (FS) wrapped method to identify important features in the dataset. The dataset used in the study contains 1385 instances and 29 features and is available at the UCI machine learning repository. The authors compare the performance of five machine learning models, including decision tree (DT), support vector machine (SVM), dummy classifier (DC), ridge classifier (RC), and bagging classifier (BC), with the hyOPTGB model. The system's efficacy is assessed using various metrics, including accuracy, recall, precision, and F1-score. The hyOPTGB model outperformed the other machine learning models, achieving a 95.3% accuracy rate. The authors also conducted a comparative study of the hyOPTGB model against other models proposed by different authors who used the same dataset.
Graviton test field in sandwich wave background
Authors: Tang Ziqian
Published: April 2023

The scattering of test fields by sandwich waves has been studied extensively. It has been found that the energy of the scattered waves is amplified for a variety of test fields. In this paper, Scattering of gravitons by sandwich waves are calculated by solving gravitational perturbations in the sandwich wave background. Dependence of their energy amplification with respect to the sandwich wave parameters and the incident wave parameters are examined . The results show that in some cases, the energy of the outgoing graviton wave is amplified as well.
Intersections of binary quadratic forms in smooth numbers
Authors: Wang Nanxiang , Dai Haobo
Published: April 2023

The number of solutions to $a^{2}+b^{2}=c^{2}+d^{2}\le x$ in integers is a well-known result, while if one restricts all the variables to primes Erd\H{o}s[4] showed that only the diagonal solutions, namely, the ones with $\{a,\,b\}=\{c,\,d\}$ contribute to the main term, hence there is a paucity of the off-diagonal solutions. A natural number $n$ is $y$-smooth if the greatest prime factor of $n$ does not exceed $y$. In this paper, we restrict some of the variables to the smooth number.
MicroRNA-29 regulates tumor progression and survival through miR-29a-SIRT1-Wnt/β-catenin pathway in hepatocellular carcinoma
Authors: Qian Liqiang , Zhang Yanjun , Wang Gang , Li Bin , Zhou Hemei , Qiu Jie , Lei Qin
Published: April 2023

Sirtuin 1 (SIRT1) participates in the initiation and evolution of hepatocellular carcinoma (HCC). However, the specific mechanism of SIRT1 in HCC remains unsolved. The mRNA expression of miR-29a in HCC were identified by qRT-PCR. miR-29a mimic and inhibitor were employed. The alteration of biological behavior was evaluated by CCK8, clone formation, Transwell and wound-healing assay. SIRT1 was verified to be a target gene which directly regulated by miR-29a. Luciferase reporter assay and co-IP were employed to evaluate the direct binding of miR-29a and SIRT1. Animal model was used to evaluate its function on tumor growth and metastasis in vivo. The relationship between miR-29a/SIRT1 and prognosis of HCC patients was analyzed. SIRT1 overexpression accompanied by low expression of miR-29a were detected in HCC which was negatively correlated, and associated with overall survival, vascular invasion and TNM stage. Up-regulation of miR-29a suppressed cell growth and motility. Deprivation of miR-29a expression led to opposite effect. The direct binding of miR-29a to SIRT1 was confirmed by luciferase reporter assay and co-IP. miR-29a repressed SIRT1, DKK2 and β-catenin, but their expression was obviously elevated by miR-29a inhibitor. Animal model suggested miR-29a reduce SIRT1 which activated Wnt/β-catenin pathway to promote HCC growth and metastasis. Low expression of miR-29a and high expression of SIRT1 predicted shorter survival time in HCC patients. miR-29a had the function of tumor suppressor which directly inhibited oncogenic SIRT1. The loss of miR-29a led to up-regulation of SIRT1, aggravate malignant transformation and poor prognosis of HCC.
Surveillance of the Field-Incurred Pesticide Residues in Kinnow Mandarin and Evaluation of Acute, Chronic and Cumulative Exposure Risks to the Consumers
Authors: BIBI AASMA
Published: April 2023

Citrus fruits may serve as potential dietary exposure pathways to toxic levels of pesticides, with which they are treated. For possible protection of the consumers, pesticide residues in citrus fruits need strict and regular monitoring. This study aimed at investigating the pesticide residues status of the raw/fresh citrus fruits i.e. Kinnow Mandarin, along with evaluating exposure risks from the detected pesticides through Kinnow Mandarin consumption. Overall, 22.5% of the samples were non-complaint to the CAC-MRLs (Codex Alimentarius Commission’s established maximum residue limits) and 77.5% were exceeding the MRLs set by EU (European Union). Bifenthrin, with highest detection rate (53%), is a registered pyrethroid acaricide/insecticide for use on citrus fruits and is among the potential endocrine disrupting substances. The estimated acute/short-term (%aRfD) and chronic/long-term (%ADI) exposure values were in the range of 0.12–29.12% and 0.001–1.186%, respectively, not exceeding the hazard limit of 100% in any case. The cumulative toxicity evaluation performed for the detected neurotoxic pesticides belonging to pyrethroid, organophosphate and neonicotinoid group, indicated low potential long-term health risks from citrus fruits consumption. The results of the health risks’ estimations denote citrus fruits consumption a safer option for its consumers.
Assessment of Lung Function of People, Chronically Exposed to Air Pollution in Delhi/NCR, India
Authors: Kumar Pawan , Gupta Sonisha , Asthana Smita , Batra Jyoti
Published: April 2023

Background: Air pollution in India is a serious issue with the major sources being motor vehicle emissions, thermal power stations, cooling towers, biomass burning, fuel adulteration, factory smoke, and stubble burning. Chronic exposure to ambient air pollution has obtunded effects on the development of lung function in children and detrimental effects on lung function of adults. The adverse effects of pollution on lung function increase the development of lung diseases in the future. Aims and Objective: The aim of the study was a comparison of lung function between two groups of population with different occupations, one group with outdoor occupation (high exposure) and second group with indoor occupation (low exposure). Settings and Design: It was a cross-sectional study and the sampling approach was Quota sampling. Quota sampling is a type of non-probabilistic sampling. There are certain groups of people who are particularly vulnerable to ambient air pollution because of their sustained high exposure like traffic police personnel deputed at traffic junctions, auto rickshaw driver/Taxi driver, E-Rickshaw driver plying in this area, and road side vendors this group. Low exposure group chosen were employee of offices and showrooms who are working indoor. Methods and Materials: This study was a two groups of 245 participants in each. First group with outdoor occupation and second group with indoor occupation having different level of exposure to air pollution due to their nature of occupation. Lung function parameters FEV1, FVC, FEV1/FVC, PEFR, and FEF were compared between two groups. Statistical Analysis: SPSS 26 software was used. Independent “T” test for continuous data type for different population, paired “T” test within the group, and Chi-square test for categorical data were applied. Results: Among high exposure group, 62.7% and 9.4% were found to have restrictive and normal lung function pattern, respectively. In comparison, among low exposure group, 31% and 59.5% were found to have restrictive and normal lung function pattern, respectively. Among outdoor group, there was a significant decline of lung function parameters such as FEV1, FVC, FEV1/FVC, PEFR, and FEF in comparison to indoor group. Conclusion: In this study, the lung function parameters were decreased in population working outdoor and chronically exposed to air pollution, in comparison to indoor subjects.
Artificial Intelligence Based Automatic Speech Emotion and Drunkenness Detection Using Convolutional Neural Network Voice Segment Dropout Optimizer
Authors: Geetha T. , Annamalai M. , Vigneshwaran R. J. , Yuvaraj A.
Published: April 2023

Speech recognition is far from an easy task, because of the unique nature of the human emotional text and a speech recognition model must strike a balance between being accurate. It should be accurate and sufficient enough to cause a broad group of datasets to separate and prevent errors. The models of the states created using artificial intelligence: Positive, sadly angry, and likely to fall are the easy ways to find the drunkenness or non-drunkenness. By building on the previous methods of emotional detection, drunkenness data set experiences can accurately identify these states. The solution development goal is to evaluate in real time because of the different voice recognition from consumers. It is reported to give the user an idea of what emotion they are experiencing or whether they are stumbling, if an assistant detects a drunk person, it will alert him or her about or making large online data extracted drunk information. If the model proves reliable, it can be used in voice-activated, the artificial intelligence (AI) is characterized by a lack of social or situational awareness of the person with it interacts to active on first stage. The second stage to direct on support Artificial Intelligence and Convolutional Neural Network Voice Segment Dropout Optimizer (CNN-VSDO) algorithm is a system that maintains the issues mentioned above that minimize the risk of overlapping. The convolutional neural network for classification employs filters to features from the spectrogram. This approach is used in personal assistant systems to provide the highest and most suitable of AI-human interaction and more appropriate state-based interactions between AI and humans.
To Assess Postural Discomfort of School Students using Virtual Pedagogy
Authors: Mishra Niharika , Agrawal Shalini , Sharmila Khwairakpam
Published: April 2023

Posture is usually defined as the relative arrangement of the parts of the body. It was observed that school teachers worked continuously in one posture for long hours. Constantly, they suffered from discomfort in different parts of their body, especially in the shoulders, knees, back, lower back, and upper back, which mainly prevent them from continuing their work. Aim: The purpose of this study was to assess the postural discomfort of the teachers using virtual pedagogy. With this background, this study was carried out with the objectives to assess. Objective: The postural discomfort faced by school teachers across gender. Methods: The sample size was 100 school students and sample was collected from Lucknow city using interview schedule along with a technique for measuring postural discomfort scale prepared by Corlett, E.N. and Bishop, R.P. (1976). The collected data were coded, scored, tabulated, and analyzed using relevant descriptive statistics frequency, percentage, mean and standard deviation, and relational statistics like correlation. The sample was collected through random and purposive random sampling technique. The data calculated were analyzed using frequency, percentage, and correlation. Results: There is no significant difference between gender and postural discomfort of respondents.
Artificial Intelligence Based on Identifying Face Mask Wearing Detection Using Recurrent Neural Network
Authors: Nithya M. , Bharanidharan R. , Dinesh M. , Srinivasan V.
Published: April 2023

COVID-19 has established a brand new frequency, and people have started realizing that they are entering a new world. The society is currently undergoing rapid change and needs to respond rapidly to fresh norms which surround us all. Creating a risk-free environment is a priority for everyone as life has not been as conductive as before brand new plans are methodized daily to adapt to policies and controls. The facial mask detection platform uses artificial intelligence see if the user is wearing a mask. App users can also add faces and phone numbers to warn themselves if they are not wearing a mask. A notice is issued to the administrator if the face captured by the camera is not recognized. Several COVID tracking tools are acceptable and safe in many aspects of the society. The most important tool is mask inspection using the proposed method, the artificial intelligence-based recurrent neural network (RNN) algorithm is enabled to capture the input image from the image classification in the dataset. However, in the overlapping scene, a different size and localization face mask detector provide a plurality of face images of the detected face. Detected faces extracted from this are grouped based on the human face detection. The recurrent neural network (RNN) algorithm using classifier and detection the mask or unmasked faces classifier. If the result is decoded from the stage, the final output is detected using all face images in the image correctly and then a message is sent to the surface and e-mail send that is not either of the mask or unmask.
Lung Infection Detection using Progressive UNet Architecture
Authors: Pandey Ashish , Dubey Sandeep
Published: April 2023

The fragmentation of medical images of tissue anomalies in organs or the blood vascular system is critical for any computerized diagnostic system. Nevertheless, automated segmentation in medical image analysis is complex since it requires in-depth information about the target organ architecture. This paper presents UNet, an end-to-end deep learning segmentation technique for early recognition of COVID. The proposed UNet model is progressive and capable of diagnosing different lung infection types along with COVID-19 infection. For this, computed tomography images are considered. The XGBoost classifier is integrated with UNet for feature classification in this model. The result analysis was performed on different convolution neural network models, that is, ResNet50, Inception, ResNet101, ResNet152, DenseNet, and UNet. These models were implemented on MATLAB using the deep neural network toolbox. From the result, it has been noticed that Inception achieved a minimum accuracy of 85.2%, and UNet achieved 99% of accuracy. It has been observed that UNet achieved approx. 16% of improvement over the inception model.
A Novel Approach to Facilitate Arousal Following Infectious Encephalitis in Acute Setup – A Case Report
Authors: Patoliya Foram , Khunt Bansi , Pithiya Labhu , Solanki Kinjal , Devani Riya , Padiya Mansi , Shah Aarsi
Published: April 2023

Encephalitis is the inflammatory disease of brain parenchyma that manifests with a spectrum of disorders including altered consciousness, impaired cognition, associated neurological impairments, aphasia, behavioral abnormalities leading to an increase in economic burden as well as delayed prognosis. However, initiating early rehabilitation to promote arousal that is task based and has associated personal salience to the patient can pay way to early arousal and shorter length of stay in acute unit. We developed a subject specific integrated multisensory stimulation technique (SSIMS) to facilitate arousal following encephalitis in acute setup. We observed improvement on Glasgow’s coma scale and Coma recovery scale following 7 days of intervention. Early task based functional therapy to target arousal along with conventional therapy can pay way to better outcomes.
Exploring the Role of Social Connectedness and Health Anxiety in Predicting Psychological Well-being
Authors: Shaikh Ezaz , Pratika Petare
Published: April 2023

Background: Due to COVID-19 pandemic, social distancing was taken as one of the precautionary measure in India. Uncertainty about signs and symptoms, modes of transmission, and lack of definite treatment of COVID-19 have put the mental health of people in India at risk. This study was carried out to explore the role of connectedness, affiliation, and companionship factors of social connectedness and health anxiety in predicting psychological well-being and its components. Method: This study was carried out on 317 Indian adults recruited through convenience sampling method during July 2020 to November 2020. Hypotheses were tested using linear regression methods. Results: Companionship predicted 1.9% and 7.7% of variance in autonomy and environmental mastery, respectively. Affiliation predicted 6.7% variance in personal growth. Connectedness and companionship explained 26.8% variance of positive relationships with others and 16.1% of self-acceptance. Health anxiety predicted 6.3%, 6.8, 6.7%, 8.3%, and 9% variance of autonomy, environmental mastery, personal growth, positive relationship with others, and self-acceptance, respectively. Conclusion: “Connectedness” and “companionship” were the significant predictors of “positive relationships with others” and “self-acceptance.” “Companionship” predicted “autonomy” and “environmental mastery,” whereas “personal growth” was predicted by “affiliation.” Health anxiety predicted all domains of psychological well-being except purpose of life.
Platelet-rich Fibrin – A Wonder Material for Periodontal Regeneration – A Clinical Case Series
Authors: Saripalli Nidhi , Sinha Rinisha , Waghmare Pramod , Sabharwal Aishwarya
Published: April 2023

The discovery of platelet-rich fibrin has enhanced the possibility of treating periodontal defects with significantly positive results in terms of bone defect fill, probing pocket depth, and clinical attachment level, apart from aiding in healing of wounds in other surgical procedures. This case series describes the use of platelet-rich fibrin (PRF) as a membrane along with allografts, in the treatment of intrabony periodontal defects, and the success of this treatment in eliminating factors such as deep periodontal pockets. The use of PRF in periodontal surgical procedures has been amply supported by various authors in the literature. Hence, it can be concluded from this case series that PRF can be used as an autologous alternative to the artificial materials for specifically treat intrabony periodontal defects with equal or better clinical outcomes.
Retrospective Analysis of Suspected Clinical Cases of Human Brucellosis in Anand, Gujarat, India
Authors: Patel Jinal , Singh Suman
Published: April 2023

Introduction: Brucellosis is a zoonosis that is emerging in some parts of the world. Although, brucellosis is a mandatory reporting disease and is not eliminated in Gujarat. The aim of the present study was to study the prevalence of human brucellosis in Anand district of Gujarat along with the trend of the disease over a period of 6 years. We also tried to study the common clinical presentations and diagnostic test used for confirmation of cases. Methods: In this study, we retrospectively analyzed the data available at the Shree Krishna Hospital, Karamsad during the past 6 years (2015 ± 2021) to get insight into the prevalence of human brucellosis in Gujarat. Results: According to the available data, 113 samples had positive serology for Brucella spp. The age of the patients enrolled in the study ranged from 12 to 78 years with an average age of 35.58. The majority were males 96 (85%), Out of 113 patient’s total 37 patients admitted to the hospital in year 2019. According to the available data, out of a total of 113, 55 patients were positive for Brucella abortus, while only nine patients were positive for Brucella melitensis. Conclusion: As this study constitutes a retrospective analysis, some of its methodological limitations relate to the lack of information that would allow a more comprehensive analysis of risk factors (e.g., occupation, risk factors, and area of residence of patients).
Subject Specific Integrated Multisensory Stimulation Program A Ray of Hope to Facilitate Arousal Following Traumatic Brain Injury
Authors: Shah Aarsi , Rathod Priyanshu V.
Published: April 2023

Objective: The objective of the study was to test a newly developed subject specific integrated multisensory stimulation program (SSIMS) on arousal of patients in coma following traumatic brain injury (TBI). Design: Parallel group pilot randomized controlled trial. Patients: Twenty patients in coma following TBI from a tertiary care hospital with Glasgow coma scale score ≤8 and hemodynamically stable participated in the study. Interventions: Conventional coma stimulation was administered to control group and SSIMS to the experimental group participants. Measurement and Main Results: Baseline assessment was done using Coma Recovery Scale Revised (CRS-R) and Sensory Stimulation Assessment Measure by a blinded outcome assessor. Reassessment was done on 7th day and 14th day post initiation of treatment in both groups. Patients in the experimental group showed better improvement on 7th day (P = 0.04) and on 14th day (P = 0.009) of intervention on arousal measured by CRS-R scores. Conclusion: SSIMS is a safe and feasible protocol to improve arousal in comatose patients post TBI, which could be a better choice for coma stimulation in routine clinical setups.
Cost of holographic path integrals
Authors: Chandra A. Ramesh , de Boer Jan , Flory Mario , Heller Michal P. , Hörtner Sergio , Rolph Andrew
Published: April 2023

We consider proposals for the cost of holographic path integrals. Gravitational path integrals within finite radial cutoff surfaces have a precise map to path integrals in T\overline{T}TT¯ deformed holographic CFTs. In Nielsen’s geometric formulation cost is the length of a not-necessarily-geodesic path in a metric space of operators. Our cost proposals differ from holographic state complexity proposals in that (1) the boundary dual is cost, a quantity that can be 'optimised' to state complexity, (2) the set of proposals is large: all functions on all bulk subregions of any co-dimension which satisfy the physical properties of cost, and (3) the proposals are by construction UV-finite. The optimal path integral that prepares a given state is that with minimal cost, and cost proposals which reduce to the CV and CV2.0 complexity conjectures when the path integral is optimised are found, while bounded cost proposals based on gravitational action are not found. Related to our analysis of gravitational action-based proposals, we study bulk hypersurfaces with a constant intrinsic curvature of a specific value and give a Lorentzian version of the Gauss-Bonnet theorem valid in the presence of conical singularities.
Impact of Message Characteristics on Viral Video Advertising
Authors: Dubal Rushit , Bhatia Hitesh
Published: April 2023

Viral video advertising is one of the active tools used by organizations to optimise social media presence. Marketers aim to generate video that motivate viewers to engage with it, in form of share, comment, like, which ultimately increases content consumption, brand awareness and engagement. This study focuses on different aspects of message characteristics and their impact on video virality. Creative professionals from advertising agencies and production studios were interviewed using semi-structured interviews to explore the role of message factors, which influences large set of viewers to engage with videos. The study provides insights on how high video virality is influenced by a specific aspect(s) of message factors and helps professionals in viral video creation.
Para além do churrasco: identidade, cultura e o pampa em discussão
Authors: Hammerschmitt Alini , Aguiar Loíze
Published: April 2023

Este artigo propõe-se a discorrer, com base em pesquisa bibliográfica, sobre questões em torno das identidades culturais, das tradições, das memórias sociais e do patrimônio cultural da comida do pampa gaúcho, objetivando argumentar que esta pode ser vista como identitária, regional e pertencente à cultura imaterial. Para tanto, começamos tratando dos conceitos de identidade e tradição, para posteriormente abordarmos os conceitos de patrimônio cultural e memória social, bem como tópicos sobre a presença feminina e da mídia em contextos que envolvem as comidas típicas dos gaúchos. Por tudo o que aqui foi abordado, considera-se que a comida pampeira é um forte componente de identidades que se entrecruzam nas regiões do pampa gaúcho, mas que sobretudo se afirmam nos saberes, nos fazeres e nas memórias desses locais. É preciso diálogo e mais atenção de pesquisas e aporte de políticas públicas para compreender e encontrar todos os elementos dessa comunhão que recaem sobre a alimentação campeira e o simbólico atrelado à região.
Estudo da incidência de fluorose dentária na dentição permanente no município de Joinville
Authors: Claudia Gastaldi de M. M. Lopes CORRÊA  , Sylvio MONTEIRO JÚNIOR  , Maria Dalva de Souza SCHROEDER
Published: April 2023

Este estudo avaliou a incidência de fluorose dentária em 640 escolares, de 6 a12 anos, da rede pública de ensino. Os dados obtidos permitiram determinare estabelecer os índices comunitário e individual de fluorose, como preconizadopor Dean e Arnold (1943) [7], a prevalência de cárie dentária e o índice deCPO-D (dentes cariados, perdidos e obturados), relacionando cárie dentária egrau de fluorose. A utilização de água de abastecimento fluoretada, somada apastas dentais, bochechos ou suplementos fluoretados em crianças de 6 a 12anos, determinou baixos índices de cárie em Joinville, porém uma fluoroseconsiderada entre leve e muito leve foi constatada na população estudada. Acidade apresentou fluorose média de 0,244 e CPO-D máximo de 2,6 aos 12anos. O estudo concluiu que a fluoretação das águas e métodos tópicos de usodo flúor são medidas eficazes de combate à doença cárie, porém existe riscode fluorose, embora baixo. É prudente a realização de mais estudos paraacompanhar a prevalência e a severidade da anomalia em Joinville, bem comoo controle da concentração adequada de flúor nos sistemas públicos defornecimento de água.
Odontologia do trabalho: O processo galvânico e sua interação com a saúde bucal do trabalhador
Authors: Fernanda Manuela CORTIANO  , Gracieli Letícia RODEGE  , Eduardo PIZZATTO
Published: April 2023

O objetivo deste trabalho foi investigar os problemas bucais que maisafetam os trabalhadores expostos a agentes químicos em indústriasgalvânicas. Foram selecionadas duas indústrias (A e B) na região deCuritiba (PR). Em cada uma foi escolhido um grupo de trabalhadoresligado diretamente ao processo galvânico e outro não. Realizaram-seinspeção da indústria e aplicação de um questionário aostrabalhadores, além do exame clínico extra e intrabucal. Os dadoscoletados foram analisados, e não houve resultados significativosdentro de cada indústria. Quando comparadas, a indústria Bapresentou maior índice de sintomas.
Histomorfologia do reparo após tratamento endodôntico em dentes com rizogênese incompleta: Revisão de literatura
Authors: Verônica Milicich SEIBEL  , Renata Grazziotin SOARES  , Orlando LIMONGI
Published: April 2023

O objetivo deste trabalho foi realizar uma revisão bibliográfica sobre ahistomorfologia do reparo de dentes com rizogênese incompleta quereceberam tratamento endodôntico. Embora o mecanismo histológico doreparo ainda permaneça relativamente obscuro e sua explicação encontrecontrovérsia na literatura, há o consenso de que a barreira de tecidoduro apical pode ser formada por dentina ou cemento, em dependênciadas células que estiverem presentes no momento da intervenção. Amorfologia do reparo da região apical tem sido estudada e caracterizadade duas formas: pelo aparecimento de substância radiopaca que obstruia abertura apical simplesmente ou pela complementação dodesenvolvimento radicular com deposição de tecido duro apical, podendoa raiz do elemento dentário apresentar diversas configurações. O hidróxidode cálcio continua sendo o material mais requisitado nesse tipo detratamento, mesmo que alguns pesquisadores sustentem que ofechamento apical ocorra quando controlada a infecção e sem a utilizaçãode um material indutor de tecido mineralizado.
Avaliação in vitro de três condicionadores de tecido submetidos a testes de penetração
Authors: Daniel Maranha da ROCHA  , Ilana Serafim dos SANTOS  , Lilian Eiko MAEKAWA  , Lafayette NOGUEIRA JÚNIOR  , Marcos Yasunori MAEKAWA
Published: April 2023

Introdução e objetivo: O objetivo do estudo foi avaliar a existência dealterações na resiliência de quatro diferentes condicionadores de tecido:Coe Comfort (CC), Ufi-Gel (UG), Sofreliner S (SS) e Sofreliner MS(SMS), associados aos seus respectivos selantes de superfície emdiferentes intervalos de tempo. Material e métodos: Foramconfeccionadas 160 cápsulas de resina acrílica que, após seuacabamento, foram preenchidas com os condicionadores de tecido.Para o grupo CC não houve tratamento da superfície interna dascápsulas, sendo o material preparado conforme as indicações do fabricante e acomodado nas cápsulas, e para os condicionadores detecido UG, SS e SMS realizou-se o tratamento interno das cápsulas.Após a obtenção dos corpos-de-prova, estes foram submetidos a testesde penetração, realizados nos intervalos de 1h, 24h, 30 e 60 dias.Resultados: Avaliou-se o efeito do fator tempo na resiliência dessesmateriais e observou-se que o CC foi o condicionador que mais perdeuessa característica com o passar do tempo, comprovando que seu usoestá limitado apenas por curto período. Já os condicionadores UG,SS e SMS, apesar de terem uma pequena deficiência na resiliência naprimeira hora, demonstraram-se mais estáveis após todos os testesao final de 60 dias. Conclusão: Condicionadores de tecido à base desilicona permanecem com as características iniciais por até 60 dias,enquanto condicionadores de tecido à base de resina acrílica perdemprogressivamente sua viscoelasticidade.
Cone beam tomography evaluation of lingual cortical mandibular defect diagnosed as Stafne bone cavity
Authors: Allan ABUABARA  , Flares Baratto-Filho  , Giuseppe Valduga CRUZ  , Liliane GUERINO  , Allan GIOVANINI
Published: April 2023

Introduction: Mandibular lingual bone depressions are considered tobe developmental anomalies known as Stafne bone cavity. The purposeof the present report is to describe the characteristics of classic Stafnebone cavity in molar region evaluated by cone beam computedtomography (CBCT). Case report: A male patient, 27 years old, wassubmitted to CBCT to evaluation of the relation between the right lowerthird molar roots and mandibular canal and the unilateral cystic imagefound in the panoramic radiographic below the mandibular canal in theright molar area. It was used a gray scale of 12 bits and voxel of 0.2 mm. The CBCT showed fine images of the Stafne bone cavity. In the presentcase, periodic clinical and radiological controls were the therapeuticoption. In atypical cases or in doubtful diagnosis, surgical interventionand anatomopathological examination may be indicated. Conclusion:Although the diagnosis of a Stafne bone cavity can often be establishedwith plain radiographs, confirmatory tests are sometimes required. Inthese situations, the diagnosis can be confirmed with CBCT.
Adaptação marginal em prótese livre de metal, observada por meio de microscopia eletrônica de varredura, após três anos em função
Authors: Marcio José Fraxino BINDO  , Rogério Goulart da COSTA  , Eduardo Christiano Caregnatto de MORAIS  , Moira Pedroso LEÃO  , Sávio Marcelo Leite Moreira da SILVA
Published: April 2023

Introdução: As cerâmicas são consideradas uma excelente alternativa como material estético restaurador, entretanto questões relevantes, como adaptação marginal, exigem um maior critério na confecção quando comparadas aos sistemas convencionais. Objetivo: Este trabalho avaliou a adaptação marginal de uma coroa In-Ceram confeccionada sobre um dente que, após 3 anos, teve sua extração indicada pela ortodontia. Material e métodos: A avaliação deu-se por meio de microscópio eletrônico de varredura. Resultados e conclusão:Foram encontrados valores de falta de adaptação entre 157 e 390 µm, obtendo uma média estatística acima do considerado aceitável clinicamente pela literatura.
Materiais utilizados no tratamento das perfurações endodônticas
Authors: Deborah Meirelles COGO  , José Roberto VANNI  , Thiago REGINATTO  , Volmir FORNARI  , Flares BARATTO FILHO
Published: April 2023

Introdução: As perfurações endodônticas são comunicações artificiais que ligam o endodonto com os tecidos de suporte dentários, sendo responsáveis pela falha de uma porcentagem considerável dos tratamentos endodônticos. Seu prognóstico depende de diversos fatores, tais como: tamanho e localização da comunicação, comprimento da raiz, facilidade de acesso, presença ou não de comunicação periodontal com o defeito, tempo decorrido entre sua ocorrência e o seu fechamento, presença de contaminação e material utilizado para o preenchimento da perfuração. Objetivo e revisão de literatura: Avaliar os materiais mais empregados atualmente no reparo das perfurações radiculares, comparando cada um deles com os resultados obtidos. Conclusão: Dos materiais usados e mais recomendados, merecem destaque o MTA e os restauradores adesivos, devendo-se sempre observar, no momento da escolha, as condições prévias encontradas, como localização da perfuração, presença de umidade, contaminação da perfuração e acesso ao defeito.
Avaliação da formação de pigmento escuro quando da mistura da solução de hipoclorito de sódio, em diferentes concentrações, com digluconato de clorexidina a 0,2%
Authors: Luis Eduardo Duarte IRALA  , Tiago André Fontoura de MELO  , Renata Grazziotin SOARES  , Fernanda LOUZADA  , Joana JUCHEM
Published: April 2023

Introdução e objetivo: Este estudo teve como objetivo verificar a formação de pigmentos escuros por meio da mistura de solução de hipoclorito de sódio, em diferentes concentrações, com digluconato de clorexidina. Material e métodos: Misturou-se 1 mL de solução de hipoclorito de sódio nas concentrações de 0,5%, 1-1,5%, 2,5-3%, 4,5-5% com 1 mL de clorexidina a 0,2% em placas de Petri. Após 5 minutos, foram feitas as leituras das placas. Resultados e conclusão: Por meio dos resultados obtidos, observou-se que em todas as misturas houve a formação de um pigmento escuro.
Universiteit van het Noorden: vier eeuwen academisch leven in Groningen: Deel 1 De oude universiteit, 1614-1876
Authors: van Berkel Klaas
Published: April 2023

Toen de Franse regeringscommissaris Georges Cuvier in 1811 de Groningse universiteit bezocht, verbaasde hij zich erover dat deze universiteit in een uithoek van het keizerrijk al bijna twee eeuwen een baken van beschaving en verlichting was. En zo is het nog altijd. De Groningse universiteit, die 400 jaar bestaat, paart sinds haar oprichting een sterke internationale uitstraling aan een actieve rol in het culturele, intellectuele en economische leven van Noord-Nederland. Soms dreigde deze excentrische ligging haar fataal te worden, maar uit elke crisis kwam de universiteit sterker tevoorschijn. Zij telde geleerden van Europees formaat, zoals de wiskundige Johann Bernoulli, de medicus Petrus Camper, de astronoom J.C. Kapteyn en de filosoof/psycholoog Gerardus Heymans. Nu behoort zij tot de beste honderd universiteiten van de wereld. Klaas van Berkel vertelt de kleurrijke geschiedenis van de universiteit, met oog voor het detail én de grote lijn.
ОСОБЛИВОСТІ АНАБОЛІЧНО-КАТАБОЛІЧНОГО БАЛАНСУ ПУРИНІВ У ПАЦІЄНТІВ З ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ З РІЗНИМ МЕТАБОЛІЧНИМ ФЕНОТИПОМ
Authors: Зінич Oлеся , Шупрович Анжела , Прибила Ольга , Кушнарьова Наталія , Ковальчук Алла , Корпачев Вадим , Шишкань-Шишова Катерина
Published: April 2023

Мета роботи: дослідження особливостей продукції та екскреції сечової кислоти (СК) у взаємозв’язку з показниками композиції тіла та ліпідного спектру у хворих на цукровий діабет 2 типу чоловічої та жіночої статі з фенотипами ожиріння та без ожиріння.
Результати. Обстежених 150 пацієнтів з ЦД 2 типу (88 чоловіків, 62 жінки), окремо чоловіків і жінок, розділено на 2 групи за ступенем ожиріння: 1) без ожиріння (ІМТ<30 кг/м2; n=61); 2) з ожирінням різного ступеня (ІМТ≥30 кг/м2; n=89). У пацієнтів з фенотипом ожиріння зафіксовано вищий рівень урикемії, меншу фракційну екскрецію уратів, вищу активність ферменту реутилізації пуринів – гіпоксантингуанінфосфорибозилтрансферази (ГГФРТ), вищі рівні секреції інсуліну, на тлі зниження екскреції СК. Розподіл пацієнтів на групи за рівнем вісцерального жиру (ВЖ) показав, що фенотип абдомінального ожиріння (ВЖ>12 од.) сприяв підвищенню рівня СК у жінок з високим рівнем ВЖ та в обох групах чоловіків, вірогідно, під впливом вищих рівнів інсуліну та зниження фракційної екскреції уратів.
Висновки. Гіперпродукція сечової кислоти у осіб з різним фенотипом може мати різне підґрунтя: якщо при ожирінні переважають анаболічні процеси з накопиченням загального та вісцерального жиру, посиленням ліпогенезу та синтезу пуринів, то при фенотипі без ожиріння превалюють катаболічні шляхи, що зумовлюють ліполіз, деградацію пуринів з утворенням кінцевого продукту – сечової кислоти.
Spatial and Temporal Arrangement of Hybrid Maize for Assesment of Phenology and Agrometeorological Indices
Authors: Wani Suffiya , Kanth Raihana Habib , Bhat Tauseef a , Adar Z , Rehman Ummaisa , Prashar Divya , Rashid Aabiro , . Raieesa , Mukhtar Sumyrah
Published: April 2023

A field trial was conducted during the Kharif season of 2020 to assess the effect of spatial and temporal crop geometry on the phenology, yield and agro meteorological indices of hybrid maize at the Agronomy Research Farm, FoA Wadura, Sopore, SKUAST-Kashmir. The experiment was carried out in split- split plot design with dates of sowing (17th SMW; D1), 19th SMW; D2 and 21st SMW; D3) as main plot treatments; varied row spacing (50 cm × 20 cm; S1, 60 cm× 20 cm; S2 and 70 cm ×20 cm; S3) as sub- plot treatments and two maize hybrids (Hytech- 5801;H1 and YSH- 1; H2) as sub- sub plot treatments. Results indicated that hybrid Hyteh- 5801 sown on 17th SMW observed highest grain yield and biological yield and took greater days to reach different phenological stages, thereby piled higher heat units, PTUs, HTUs, HyTUs, PTI followed by 19th SMW and 21st SMW. The plant spacing of 70 cm ×20 cm took maximum days for reaching different phenophases and accumulated maximum heat units, PTUs, HTUs, HyTUs, PTI. Thermal use efficiencies were maximum ((HTUE, PTUE, HyTUE and HUE)) when the maize hybrid Hytech-5801was sown on 17th SMW. The biological yield based thermal efficiencies showed the highest response with row-spacing of 50 cm × 20 cm whereas grain yield based thermal efficiencies were maximum under 70 cm×20 cm plant spacing.
Standardization of the Growing Media for maximizing Seed Germination of Ber
Authors: SINGH SURENDER , . NAJEEBULLAH , YADAV BIJENDER SINGH , . ASHISH
Published: April 2023

A field experiment to standardize the growing media for maximizing the seed germination of ber (Ziziphusmauritiana var. rotundifolia) was conducted in the nursery of Experimental Orchard, Department of Horticulture, CCS HAU Hisar. The media for the study were garden soil and sand with the different proportion of vermicompost, FYM and cocopeat constituting 16 treatments. The experiment was conducted in randomized block design. The results revealed that growing Media T7: Garden soil + FYM + VC + CP (3:1:1:1) reduced the number of days for germination (19.33 days) and increased germination percentage (74.60%). The same media also resulted into highest N content in leaves (1.47 %) over all other growing media, in ber seedlings. The data clearly indicated that significantly higher seedling height was observed under T7 - Garden soil + FYM + VC + CP (3:1:1:1) i.e. 22.73, 47.90, 71.57 and 106.43 cm at 60, 90, 120 and 150 DAS, respectively. Therefore, growing Media T7 - Garden soil + FYM + VC + CP (3:1:1:1) may be recommended for commercial cultivation.