bluuebunny/crossref_metadata_2025 huggingface dataset:
Ranking Algorithms for Word Ordering in Surface Realization
Authors: Mazzei Alessandro , Cerrato Mattia , Esposito Roberto , Basile Valerio
Published: August 2021

In natural language generation, word ordering is the task of putting the words composing the output surface form in the correct grammatical order. In this paper, we propose to apply general learning-to-rank algorithms to the task of word ordering in the broader context of surface realization. The major contributions of this paper are: (i) the design of three deep neural architectures implementing pointwise, pairwise, and listwise approaches for ranking; (ii) the testing of these neural architectures on a surface realization benchmark in five natural languages belonging to different typological families. The results of our experiments show promising results, in particular highlighting the performance of the pairwise approach, paving the way for a more transparent surface realization from arbitrary tree- and graph-like structures.
Prediction of Bladder Cancer Treatment Side Effects Using an Ontology-Based Reasoning for Enhanced Patient Health Safety
Authors: Barki Chamseddine , Rahmouni Hanene Boussi , Labidi Salam
Published: August 2021

Predicting potential cancer treatment side effects at time of prescription could decrease potential health risks and achieve better patient satisfaction. This paper presents a new approach, founded on evidence-based medical knowledge, using as much information and proof as possible to help a computer program to predict bladder cancer treatment side effects and support the oncologist’s decision. This will help in deciding treatment options for patients with bladder malignancies. Bladder cancer knowledge is complex and requires simplification before any attempt to represent it in a formal or computerized manner. In this work we rely on the capabilities of OWL ontologies to seamlessly capture and conceptualize the required knowledge about this type of cancer and the underlying patient treatment process. Our ontology allows case-based reasoning to effectively predict treatment side effects for a given set of contextual information related to a specific medical case. The ontology is enriched with proofs and evidence collected from online biomedical research databases using “web crawlers”. We have exclusively designed the crawler algorithm to search for the required knowledge based on a set of specified keywords. Results from the study presented 80.3% of real reported bladder cancer treatment side-effects prediction and were close to really occurring adverse events recorded within the collected test samples when applying the approach. Evidence-based medicine combined with semantic knowledge-based models is prominent in generating predictions related to possible health concerns. The integration of a diversity of knowledge and evidence into one single integrated knowledge-base could dramatically enhance the process of predicting treatment risks and side effects applied to bladder cancer oncotherapy.
Evaluation of Total Female and Male Aedes aegypti Proteomes Reveals Significant Predictive Protein–Protein Interactions, Functional Ontologies, and Differentially Abundant Proteins
Authors: Shettima Abubakar , Joseph Shaleni , Ishak Intan H. , Abdul Raiz Syahirah Hanisah , Abu Hasan Hadura , Othman Nurulhasanah
Published: August 2021

Aedes aegypti is a significant vector for many tropical and subtropical flavivirus diseases. Only the female mosquito transmits pathogens, while the male plays a vital role in mating and species continuity. This study explored the total proteomes of females and males based on the physiological and genetic differences of female and male mosquitoes. Protein extracts from mosquitoes were analysed using LC–ESI–MS/MS for protein identification, protein interaction network analysis, functional ontology enrichment, and differential protein abundance analyses. Protein identification revealed 422 and 682 proteins exclusive to males and females, respectively, with 608 common proteins found in both sexes. The most significant PPIs (<1.0 × 10−16) were for common proteins, followed by proteins exclusive to females (<1.0 × 10−16) and males (1.58 × 10−12). Significant functional enrichments were observed in the biological process, molecular function, and cellular component for the male and female proteins. The abundance of the proteins differed, with one protein showing an increase (elongation factor 1 α, EF1α) and two showing reductions (actin family) in females versus males. Overall, the study verified the total proteomes differences between male and female Ae. aegypti based on protein identification and interactions, functional ontologies, and differentially abundant proteins. Some of the identified proteins merit further investigation to elucidate their roles in blocking viral transmission.
Baseline Susceptibility of Spodoptera frugiperda Populations Collected in India towards Different Chemical Classes of Insecticides
Authors: Kulye Mahesh , Mehlhorn Sonja , Boaventura Debora , Godley Nigel , Venkatesh Sreedevi , Rudrappa Thimmaraju , Charan Tara , Rathi Dinesh , Nauen Ralf
Published: August 2021

Fall armyworm (FAW), Spodoptera frugiperda, is a major pest of maize in the Americas and recently invaded the Eastern hemisphere. It was first detected in India in 2018 and is considered a major threat to maize production. FAW control largely relies on the application of chemical insecticides and transgenic crops expressing Bacillus thuringiensis insecticidal proteins. Assessing FAW resistance and insecticide susceptibility is a cornerstone to develop sustainable resistance management strategies. In this study, we conducted more than 400 bioassays to assess the efficacy of nine insecticides from seven mode-of-action classes against 47 FAW populations collected in 2019 and 2020 across various geographical areas in India. The resistance status of the field-collected populations was compared to an Indian population sampled in 2018, and an insecticide susceptible reference population collected in 2005 in Brazil. Low to moderate resistance levels were observed for thiodicarb, chlorpyriphos, deltamethrin, chlorantraniliprole and flubendiamide in several populations (including the reference population collected in 2018). The highest resistance ratios were observed for deltamethrin which likely compromises recommended label rates for pyrethroid insecticides in general. Our data provide a useful baseline for future FAW resistance monitoring initiatives and highlight the need to implement insecticide resistance management strategies.
The Question of Algorithmic Personhood and Being (Or: On the Tenuous Nature of Human Status and Humanity Tests in Virtual Spaces—Why All Souls Are ‘Necessarily’ Equal When Considered as Energy)
Authors: Jaynes Tyler Lance
Published: August 2021

What separates the unique nature of human consciousness and that of an entity that can only perceive the world via strict logic-based structures? Rather than assume that there is some potential way in which logic-only existence is non-feasible, our species would be better served by assuming that such sentient existence is feasible. Under this assumption, artificial intelligence systems (AIS), which are creations that run solely upon logic to process data, even with self-learning architectures, should therefore not face the opposition they have to gaining some legal duties and protections insofar as they are sophisticated enough to display consciousness akin to humans. Should our species enable AIS to gain a digital body to inhabit (if we have not already done so), it is more pressing than ever that solid arguments be made as to how humanity can accept AIS as being cognizant of the same degree as we ourselves claim to be. By accepting the notion that AIS can and will be able to fool our senses into believing in their claim to possessing a will or ego, we may yet have a chance to address them as equals before some unforgivable travesty occurs betwixt ourselves and these super-computing beings.
Radiation Reduction and Protection for Radiosensitive Organs (Lens, Thyroid, and Genital Organs) of Patients Receiving Percutaneous Coronary Intervention—Real-World Measurement of Radiation Dose in a Single Center
Authors: Wang Wen-Hwa , Wei Kai-Che , Huang Wei-Chun , Yen Yuan-Yin , Mar Guang-Yuan
Published: August 2021

Backgrounds: Reducing radiation exposure is the basic principle for performing percutaneous coronary intervention (PCI). Many studies have confirmed the effect of radiation protection for medical staff, but studies about the effectiveness of protection for patients and real measurement of radiation dose in patients’ specific organs are lacking. Aim: To measure the radiation doses absorbed by patients’ radiosensitive organs during PCI and the effectiveness of radiation protection. Methods: A total of 120 patients were included and allocated into three groups as the ratio of 1:1:2. A total of 30 patients received PCI at 15 frames rate per second (fps), 30 patients at 7.5 fps, and 60 patients wore radiation protective hat and glasses during PCI at 7.5 fps. The radiation doses were measured at right eyebrow (lens), neck (thyroid), back (skin), and inguinal area (genital organs) by using thermoluminescent dosimeters (TLDs). Results: Dose-area product (DAP) reduced by 58.8% (from 534,454 ± 344,660 to 220,352 ± 164,101 mGy·cm2, p < 0.001) after reducing the frame rate, without affecting successful rate of PCI. Radiation doses measured on skin, lens, genital organs, and thyroid decreased by 73.3%, 40.0%, 40.0%, and 35.3%, respectively (from 192.58 ± 349.45 to 51.10 ± 59.21; 5.29 ± 4.27 to 3.16 ± 2.73; 0.25 ± 0.15 to 0.15 ± 0.15; and 17.42 ± 12.11 to 11.27 ± 8.52 μSv, p < 0.05). By providing radiation protective equipment, radiation doses at lens and thyroid decreased further by 71.8% and 65.9% (from 3.16 ± 2.73 to 0.89 ± 0.79; 11.27 ± 8.52 to 3.84 ± 3.49 μSv, p < 0.05). Conclusions: By lowering the frame rate and providing protective equipment, radiation exposure in radiosensitive organs can be effectively reduced in patients.
One-Year Outcomes after Surgical versus Transcatheter Aortic Valve Replacement with Newer Generation Devices
Authors: Rosato Stefano , Biancari Fausto , D’Errigo Paola , Barbanti Marco , Tarantini Giuseppe , Bedogni Francesco , Ranucci Marco , Costa Giuliano , Juvonen Tatu , Ussia Gian Paolo , Marcellusi Andrea , Baglio Giovanni , Cicala Stefano Domenico , Badoni Gabriella , Seccareccia Fulvia , Tamburino Corrado ,   on behalf of the OBSERVANT II Research Group
Published: August 2021

The superiority of transcatheter (TAVR) over surgical aortic valve replacement (SAVR) for severe aortic stenosis (AS) has not been fully demonstrated in a real-world setting. This prospective study included 5706 AS patients who underwent SAVR from 2010 to 2012 and 2989 AS patients who underwent TAVR from 2017 to 2018 from the prospective multicenter observational studies OBSERVANT I and II. Early adverse events as well as all-cause mortality, major adverse cardiac and cerebrovascular events (MACCEs), and hospital readmission due to heart failure at 1-year were investigated. Among 1008 propensity score matched pairs, TAVR was associated with significantly lower 30-day mortality (1.8 vs. 3.5%, p = 0.020), stroke (0.8 vs. 2.3%, p = 0.005), and acute kidney injury (0.6 vs. 8.2%, p < 0.001) compared to SAVR. Moderate-to-severe paravalvular regurgitation (5.9 vs. 2.0%, p < 0.001) and permanent pacemaker implantation (13.8 vs. 3.3%, p < 0.001) were more frequent after TAVR. At 1-year, TAVR was associated with lower risk of all-cause mortality (7.9 vs. 11.5%, p = 0.006), MACCE (12.0 vs. 15.8%, p = 0.011), readmission due to heart failure (10.8 vs. 15.9%, p < 0.001), and stroke (3.2 vs. 5.1%, p = 0.033) compared to SAVR. TAVR reduced 1-year mortality in the subgroups of patients aged 80 years or older (HR 0.49, 95% CI 0.33–0.71), in females (HR 0.57, 0.38–0.85), and among patients with EuroSCORE II ≥ 4.0% (HR 0.48, 95% CI 0.32–0.71). In a real-world setting, TAVR using new-generation devices was associated with lower rates of adverse events up to 1-year follow-up compared to SAVR.
Echocardiographic Evaluation of LV Function in Patients with Tachyarrhythmia and Reduced Left Ventricular Function in Response to Rhythm Restoration
Authors: Schach Christian , Körtl Thomas , Wachter Rolf , Maier Lars S. , Sossalla Samuel
Published: August 2021

Aims: Tachyarrhythmia due to atrial fibrillation (AF) is often associated with reduced left ventricular (LV) function and has been proposed to cause arrhythmia-induced cardiomyopathy (AIC). However, the precise diagnostics of AIC and reversibility after rhythm restoration are poorly understood. Our aim was to investigate systolic LV function in tachycardic AF and to evaluate the direct effect of rhythm restoration. Methods: We prospectively studied 24 patients (71% male, age 65 ± 9 years) with tachycardic AF and newly diagnosed reduced left ventricular ejection fraction (LVEF). Just before and immediately after electrical cardioversion (ECV), transthoracic echocardiography was performed. Geometric as well as functional data were assessed. Results: Patients presented with a heart rate (HR) of 117.4 ± 21.6/min and a 2D-/3D-LVEF of 32 ± 9/31 ± 8%. ECV to sinus rhythm normalized HR to 77 ± 11/min with an increase of 2D-/3D-LVEF to 37 ± 9/37 ± 10% (p < 0.01 vs. baseline, each). Left ventricular geometry changed with an increase of end-diastolic volume (LVEDV) while end-systolic volume (LVESV) remained unchanged. Parameters concerning myocardial deformation (global longitudinal strain (GLS), strain rate (SR)) decreased whereas the RR interval-corrected GLS (GLSc) remained unchanged. In a simple linear regression model, GLS correlated with 2D- and 3D-LVEF not only before (pre) ECV, but also after (post) ECV. We demonstrate that the increase of LVEF and GLS (ratios pre/post) correlates with the change of HR (ΔHR; R2 = 0.20, 0.33 and 0.32, p < 0.05 each), whereas ratios of GLSc and SR do not significantly correlate with HR (R2 = 0.03 and 0.01, p = n.s. each). Conclusion: In patients with tachyarrhythmia and reduced ejection fraction, ECV leads to immediate improvement in EF and GLS while HR-corrected LV contractility remains unchanged. This suggests that the immediate effects of rhythm restoration are mostly related to changes in left ventricular volume, but not to an acute improvement of heart-rate independent contractility.
Diagnostic Value of EUS-Guided Fine-Needle Aspiration Biopsy for Gastric Linitis Plastica with Negative Endoscopic Biopsy
Authors: Takada Ryutaro , Minaga Kosuke , Hara Akane , Otsuka Yasuo , Omoto Shunsuke , Kamata Ken , Yamao Kentaro , Takenaka Mamoru , Hagiwara Satoru , Honjo Hajime , Matsui Shigenaga , Chikugo Takaaki , Watanabe Tomohiro , Kudo Masatoshi
Published: August 2021

Due to the tendency of gastric linitis plastica (GLP) to cause extensive submucosal infiltration, a superficial endoscopic biopsy sometimes yields no evidence of malignancy, hindering definite diagnosis. The present study was a single-center retrospective analysis of 54 consecutive patients diagnosed with GLP between 2016 and 2020 to evaluate EUS-guided fine-needle aspiration (EUS-FNA) biopsy outcomes in patients with negative endoscopic biopsy findings. A pathological GLP diagnosis was achieved by endoscopic biopsy in 40 patients (74.1%). EUS-FNA biopsy with a 22-gauge needle was performed in 13 of the remaining 14 patients, and GLP diagnosis was confirmed in 10 patients, with a median of three needle passes. The remaining four patients were laparoscopically diagnosed with GLP. The diagnostic ability of EUS-FNA biopsy for GLP was 76.9%, and EUS-FNA biopsy contributed to GLP diagnosis in 18.5% (10/54) of all cases. None of the 13 patients exhibited EUS-FNA biopsy-related adverse events. Univariable and multivariable analyses revealed an absence of superficial ulcerations as a predictor of false-negative endoscopic biopsy findings in patients with GLP. These results suggest EUS-FNA biopsy as a minimally invasive and safe alternative diagnostic modality for GLP in cases where conventional endoscopic biopsy fails to verify malignancy, although prospective studies with larger cohorts are warranted to confirm these findings.
Predictive Role of Prior Radiotherapy and Immunotherapy-Related Adverse Effects in Advanced NSCLC Patients Receiving Anti-PD-1/L1 Therapy
Authors: Lim Jeong Uk , Kim Soo Han , Kang Hye Seon , Kim Sung Kyoung , Kim Ju Sang , Kim Jin Woo , Kim Seung Joon , Yeo Chang Dong , Choi Chang Min
Published: August 2021

The present study evaluated the impact of prior radiotherapy (RT) on patients with advanced non-small cell lung cancer (NSCLC) receiving therapy with immune checkpoint inhibitors (ICIs) and further assessed the prognostic factors in patients receiving both RT and ICI. Patients diagnosed with NSCLC at the Catholic Medical Center and Asan Medical Center between January 2016 and October 2020 and who received immunotherapy were retrospectively reviewed. Among 240 patients, poor Eastern Cooperative Oncology Group (ECOG) score, high PD-L1 expression, and ICI-related adverse events (AE) were significantly associated with progression-free survival (PFS) (HR, 2.654; 95% CI, 1.484–4.749; p = 0.001; HR, 0.645; 95% CI, 0.449–0.926, p = 0.017; HR, 0.430; 95% CI, 0.229–0.808; p = 0.009, respectively). Among patients who received both RT and immunotherapy, poor ECOG status, squamous cell carcinoma, and ICI-related AE were significant factors associated with poor PFS (HR, 2.430; 95% CI, 1.464–4.034; p = 0.001; HR, 0.667; 95% CI, 0.455–0.978, p = 0.038; HR, 0.520; 95% CI, 0.284–0.953, p = 0.034, respectively). The present study showed that prior RT showed no significant independent association with primary outcomes in patients with advanced NSCLC receiving immunotherapy. In patients who received both RT and immunotherapy, clinical parameters, including ICI-related AEs, were independently predictive of PFS.
Vascular Complications in Patients with Chronic Pancreatitis
Authors: Vujasinovic Miroslav , Dugic Ana , Nouri Amar , Brismar Torkel B , Baldaque-Silva Francisco , Asplund Ebba , Rutkowski Wiktor , Ghorbani Poya , Sparrelid Ernesto , Hagström Hannes , Löhr J.-Matthias
Published: August 2021

Introduction: Chronic pancreatitis (CP) is a long-standing progressive inflammation of the pancreas, which can lead to a variety of vascular complications, such as splanchnic venous thrombosis (VT) and arterial pseudoaneurysm (PA). There is a lack of studies on vascular complications in Scandinavian countries. Methods: We performed a retrospective analysis of medical records of patients with CP identified from the Karolinska University Hospital database between 2003 and 2018. A total of 394 patients with definite CP were included in the study. Results: There were 33 patients with vascular complications, with a median age of 62 (IQR 55–72) years. The cumulative incidence of vascular events was 3.2% at 5 years. Thirty patients had isolated VT, whereas three patients had PA (7.6% and 0.8%, respectively). Isolated splenic vein thrombosis was most common (53.3%), followed by a combination with other splanchnic veins. PA was found in the splenic artery in two patients and in the left gastric artery in one patient. Varices were present in three (10%) patients; variceal bleeding was not recorded. All patients had asymptomatic splanchnic VT, most with chronic VT with developed collaterals (83.3% had abdominal collateral vessels). Nearly two-thirds of patients with VT (63.3%) received no treatment, whereas 11 (36.6%) were treated with anticoagulants. Pseudocysts and alcoholic etiology of CP are risk factors for vascular complications. Conclusions: The cumulative incidence of vascular complications was 3.2% at 5 years. Splanchnic VT is more common than PA. Patients were asymptomatic with no variceal bleeding, explained by well-developed collateral vessels and strong study inclusion criteria.
New Insights in Microbial Species Predicting Lung Function Decline in CF: Lessons from the MucoFong Project
Authors: Francis Florence , Enaud Raphael , Soret Perrine , Lussac-Sorton Florian , Avalos-Fernandez Marta ,   MucoFong Investigation Group, Bui Stéphanie , Fayon Michael , Thiébaut Rodolphe , Delhaes Laurence
Published: August 2021

Several predictive models have been proposed to understand the microbial risk factors associated with cystic fibrosis (CF) progression. Very few have integrated fungal airways colonisation, which is increasingly recognized as a key player regarding CF progression. To assess the association between the percent predicted forced expiratory volume in 1 s (ppFEV1) change and the fungi or bacteria identified in the sputum, 299 CF patients from the “MucoFong” project were included and followed-up with over two years. The relationship between the microorganisms identified in the sputum and ppFEV1 course of patients was longitudinally analysed. An adjusted linear mixed model analysis was performed to evaluate the effect of a transient or chronic bacterial and/or fungal colonisation at inclusion on the ppFEV1 change over a two-year period. Pseudomonas aeruginosa, Achromobacter xylosoxidans, Stenotrophomonas maltophilia, and Candida albicans were associated with a significant ppFEV1 decrease. No significant association was found with other fungal colonisations. In addition, the ppFEV1 outcome in our model was 11.26% lower in patients presenting with a transient colonisation with non-pneumoniae Streptococcus species compared to other patients. These results confirm recently published data and provide new insights into bacterial and fungal colonisation as key factors for the assessment of lung function decline in CF patients.
Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma
Authors: Tsai Mu-Yao , Chiang Ping-Chia , Chen Chien-Hsu , Sung Ming-Tse , Huang Shun-Chen , Suen Jau-Ling , Tsai Eing-Mei , Chiang Po-Hui
Published: August 2021

We retrospectively enrolled 102 patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy to examine the prognostic value of Ki-67 and programmed cell death ligand-1 (PD-L1). Then, we performed PD-L1 and Ki-67 immunohistochemical staining on whole tissue sections. The cut-off value of PD-L1 positivity was a combined positive score (CPS) ≥10 and the Ki-67 overexpression was 20%. Among the 102 patients, 16.7% and 48.0% showed positive PD-L1 expression and Ki-67 overexpression, respectively. A CPS ≥10 was significantly associated with a higher pathological T stage (p = 0.049). In addition, Ki-67 overexpression was significantly associated with a pathological T stage ≥ 2 (p = 0.027) and tumour necrosis (p = 0.016). In the multivariable analysis, a positive PD-L1 expression was significantly correlated with worse cancer-specific survival (HR = 3.66, 95% CI =1.37−9.77, p = 0.01). However, there was no predictive value using a combination of PD-L1 expression and Ki-67 overexpression as a prognostic predictor. Compared with Ki-67 overexpression, a positive PD-L1 expression with CPS ≥ 10 was a stronger independent prognostic factor for CSS in patients with UTUC.
Value of Left Ventricular Feature Tracking Strain Analysis for Detection of Early Cardiac Involvement in Fabry Disease (FD)
Authors: Roller Fritz Christian , Brose Alexander , Richter Martin , Schüssler Armin , Harth Sebastian , Tanislav Christian , Krombach Gabriele Anja
Published: August 2021

Purpose: Detection of cardiac involvement in Fabry disease (FD) is of high importance for treatment management. Native T1 mapping especially showed great potential for detection of early cardiac manifestations. Echocardiographic studies showed strain abnormalities in FD patients, but data on MRI feature tracking strain analysis (FT-SA) is limited. Therefore, the aim of our study was to evaluate the potential of FT-SA compared to native T1 and the FD specific biomarker Globotriaosylsphingosine (LysoGb3). Methods: 28 consecutive FD patients (18 female; 47.8 years ± 17.4 standard deviation (SD)) and 28 control subjects (18 female; 46.6 years ± 18.2 SD) underwent cardiac MRI at 1.5 Tesla. Global native T1 times and left ventricular FT-SA were evaluated. Results were correlated to serum Lyso-Gb3-levels. Results: Native T1 times, global longitudinal (GLS) and global radial strain (GRS) were significantly reduced in FD patients (p < 0.0064, p = 0.0009 and p = 0.0184, respectively). Moreover, native T1 times and GLS were significantly lower in Lyso-Gb3 positive FD patients (p < 0.005 and p = 0.03). GLS, native T1 times showed significant moderate correlations to LysoGb3 (p = 0.002 and p < 0.001). Furthermore, GLS and native T1 times reduce when LysoGb3 was elevated and increasingly with presence of left ventricular hypertrophy (LVH) or late gadolinium enhancement (LGE). Conclusions: Native T1 times and strain values differ significantly between FD patients and control subjects and showed promising correlations to the FD specific biomarker LysoGb3. We therefore conclude that strain abnormalities occur early beside native T1 reductions in cardiac FD involvement. Large scale trials are needed to verify our findings.
High-Resolution 18F-FDG PET/CT for Assessing Three-Dimensional Intraoperative Margins Status in Malignancies of the Head and Neck, a Proof-of-Concept
Authors: Debacker Jens M. , Schelfhout Vanessa , Brochez Lieve , Creytens David , D’Asseler Yves , Deron Philippe , Keereman Vincent , Van de Vijver Koen , Vanhove Christian , Huvenne Wouter
Published: August 2021

The surgical treatment of head and neck malignancies relies on the complete removal of tumoral tissue, while inadequate margins necessitate the use of adjuvant therapy. However, most positive margins are identified postoperatively as deep margins, and intraoperative identification of the deep positive margins could help achieve adequate surgical margins and decrease adjuvant therapies. To improve deep-margin identification, we investigated whether the use of high-resolution preclinical PET and CT could increase certainty about the surgical margins in three dimensions. Patients with a malignancy of the head and neck planned for surgical resection were administered a clinical activity of 4MBq/kg 18F-FDG approximately one hour prior to surgical initiation. Subsequently, the resected specimen was scanned with a micro-PET-CT imaging device, followed by histopathological assessment. Eight patients were included in the study and intraoperative PET/CT-imaging of 11 tumoral specimens and lymph nodes of three patients was performed. As a result of the increased resolution, differentiation between inflamed and dysplastic tissue versus malignant tissue was complicated in malignancies with increased peritumoral inflammation. The current technique allowed the three-dimensional delineation of 18F-FDG using submillimetric PET/CT imaging. While further optimization and patient stratification is required, clinical implementation could enable deep margin assessment in head and neck resection specimens.
Effect of Systemic Steroid Use for Immune-Related Adverse Events in Patients with Non-Small Cell Lung Cancer Receiving PD-1 Blockade Drugs
Authors: Mouri Atsuto , Kaira Kyoichi , Yamaguchi Ou , Hashimoto Kousuke , Miura Yu , Shiono Ayako , Shinomiya Shun , Imai Hisao , Kobayashi Kunihiko , Kagamu Hiroshi
Published: August 2021

Objectives: Programmed death-1(PD-1)/programmed death ligand-1 (PD-L1) antibodies have clinical benefits for cancer patients facing immune-related adverse events (irAEs). However, the effect of steroid use on the prognosis of patients with non-small cell lung cancer (NSCLC) receiving PD-1 blockade remains unclear. Methods: NSCLC patients with complete response (CR)/partial response (PR) or stable disease (SD)/not evaluable (NE) status plus progression-free survival (PFS) of 180 days after PD-1 blockade from December 2015 to December 2018 were retrospectively registered in our study and were divided into two groups: those with and without systemic steroid use for irAEs. Results: In total, 126 patients who had benefitted from PD-1 blockade were enrolled in our study; among them, 44 received systemic steroids for irAEs, and 82 had no adverse events or, if they did, did not receive systemic steroids. Among the 44 patients requiring steroids, interstitial lung disease (ILD), adrenal insufficiency, diarrhea, and liver dysfunction were observed in 19, 9, 4, and 4 patients, respectively. More side effects were observed in the group treated by steroids. The median PFS and overall survival (OS) in patients with and without systemic steroid use were 11.7 and 16.0 months (p < 0.037) and 35.0 and 41.0 months (p < 0.28), respectively. In univariate and multivariate analyses of survival, systemic steroid treatment for irAEs was significantly associated with PFS. The occurrence of ILD, adrenal insufficiency, and fever was significant in patients who used systemic steroids for irAEs. Conclusions: Patients administered systemic steroids for irAEs due to PD-1 blockade treatment exhibited shorter PFS than those who were not. Systemic steroids might affect survival after PD-1 blockade even for patients who once acquired its clinical benefit.
Hysterolaparoscopy: A Gold Standard for Diagnosing and Treating Infertility and Benign Uterine Pathology
Authors: Varlas Valentin , Rhazi Yassin , Cloțea Eliza , Borș Roxana Georgiana , Mirică Radu Mihail , Bacalbașa Nicolae
Published: August 2021

Background: Combined hysteroscopy and laparoscopy is a valuable method for diagnosing and treating infertility and benign uterine pathology. Both procedures are minimally invasive, reliable, and safe, with a low complication rate. Aim: In this review, we expose the efficiency and safety of hysterolaparoscopy in the management of infertility and other benign uterine pathologies. Method: We performed a systematic literature review on several databases: PubMed®/MEDLINE, PMC, Crossref.org, and Web of Science in the last 10 years. Inclusion criteria: Women of reproductive age with primary or secondary infertility and/or benign uterine pathology. Exclusion criteria: pre-puberty, menopause, couple with male infertility. Conclusion: Hysterolaparoscopy is a useful tool to assess infertility and simultaneously diagnose and treat pelvic and uterine lesions.
Risk of Early Childhood Obesity in Offspring of Women with Preeclampsia: A Population-Based Study
Authors: Yang Seung-Woo , Oh Min-Jeong , Park Keon-Vin , Han Sung-Won , Kim Hee-Sun , Sohn In-Sook , Kwon Han-Sung , Cho Geum-Joon , Hwang Han-Sung
Published: August 2021

Preeclampsia (PE) is a major disease of pregnancy, with various short- or long-term complications for both the mother and offspring. We focused on the body mass index (BMI) of offspring and compared the incidence of obesity during early childhood between PE- and non-PE-affected pregnancies. Women with singleton births (n = 1,697,432) were identified from the Korea National Health Insurance database. The outcomes of offspring at 30–80 months of age were analyzed. The effects of PE on BMI and the incidence of obesity in the offspring were compared. The incidence of low birth weight (LBW) offspring was higher in the PE group (n = 29,710) than that in the non-PE group (n = 1,533,916) (24.70% vs. 3.33%, p < 0.01). However, BMI was significantly higher in the PE-affected offspring than that in non-PE-affected offspring. After adjusting for various factors, the risk of obesity was higher in the PE-affected offspring (odds ratio = 1.34, 95% confidence interval = 1.30–1.38). The BMI and incidence of obesity were higher during early childhood in the PE-affected offspring, even though the proportion of LBW was higher. These results may support the basic hypotheses for the occurrence of various cardiovascular and metabolic complications in PE-affected offspring. In addition, early-age incidence of obesity could influence PE management and child consultation in clinical applications.
Documenting Paintings with Gigapixel Photography
Authors: Cabezos-Bernal Pedro M. , Rodriguez-Navarro Pablo , Gil-Piqueras Teresa
Published: August 2021

Digital photographic capture of pictorial artworks with gigapixel resolution (around 1000 megapixels or greater) is a novel technique that is beginning to be used by some important international museums as a means of documentation, analysis, and dissemination of their masterpieces. This line of research is extremely interesting, not only for art curators and scholars but also for the general public. The results can be disseminated through online virtual museum displays, offering a detailed interactive visualization. These virtual visualizations allow the viewer to delve into the artwork in such a way that it is possible to zoom in and observe those details, which would be negligible to the naked eye in a real visit. Therefore, this kind of virtual visualization using gigapixel images has become an essential tool to enhance cultural heritage and to make it accessible to everyone. Since today’s professional digital cameras provide images of around 40 megapixels, obtaining gigapixel images requires some special capture and editing techniques. This article describes a series of photographic methodologies and equipment, developed by the team of researchers, that have been put into practice to achieve a very high level of detail and chromatic fidelity, in the documentation and dissemination of pictorial artworks. The result of this research work consisted in the gigapixel documentation of several masterpieces of the Museo de Bellas Artes of Valencia, one of the main art galleries in Spain. The results will be disseminated through the Internet, as will be shown with some examples.
A Dataset of Annotated Omnidirectional Videos for Distancing Applications
Authors: Mazzola Giuseppe , Lo Presti Liliana , Ardizzone Edoardo , La Cascia Marco
Published: August 2021

Omnidirectional (or 360°) cameras are acquisition devices that, in the next few years, could have a big impact on video surveillance applications, research, and industry, as they can record a spherical view of a whole environment from every perspective. This paper presents two new contributions to the research community: the CVIP360 dataset, an annotated dataset of 360° videos for distancing applications, and a new method to estimate the distances of objects in a scene from a single 360° image. The CVIP360 dataset includes 16 videos acquired outdoors and indoors, annotated by adding information about the pedestrians in the scene (bounding boxes) and the distances to the camera of some points in the 3D world by using markers at fixed and known intervals. The proposed distance estimation algorithm is based on geometry facts regarding the acquisition process of the omnidirectional device, and is uncalibrated in practice: the only required parameter is the camera height. The proposed algorithm was tested on the CVIP360 dataset, and empirical results demonstrate that the estimation error is negligible for distancing applications.
Usability of Graphical Visualizations on a Tool-Mounted Interface for Spine Surgery
Authors: Schütz Laura , Brendle Caroline , Esteban Javier , Krieg Sandro M. , Eck Ulrich , Navab Nassir
Published: August 2021

Screw placement in the correct angular trajectory is one of the most intricate tasks during spinal fusion surgery. Due to the crucial role of pedicle screw placement for the outcome of the operation, spinal navigation has been introduced into the clinical routine. Despite its positive effects on the precision and safety of the surgical procedure, local separation of the navigation information and the surgical site, combined with intricate visualizations, limit the benefits of the navigation systems. Instead of a tech-driven design, a focus on usability is required in new research approaches to enable advanced and effective visualizations. This work presents a new tool-mounted interface (TMI) for pedicle screw placement. By fixing a TMI onto the surgical instrument, physical de-coupling of the anatomical target and navigation information is resolved. A total of 18 surgeons participated in a usability study comparing the TMI to the state-of-the-art visualization on an external screen. With the usage of the TMI, significant improvements in system usability (Kruskal–Wallis test p < 0.05) were achieved. A significant reduction in mental demand and overall cognitive load, measured using a NASA-TLX (p < 0.05), were observed. Moreover, a general improvement in performance was shown by means of the surgical task time (one-way ANOVA p < 0.001).
Contamination Evaluation of Heavy Metals in a Sediment Core from the Al-Salam Lagoon, Jeddah Coast, Saudi Arabia
Authors: Mannaa Ammar A. , Khan Athar Ali , Haredy Rabea , Al-Zubieri Aaid G.
Published: August 2021

The Al-Salam Lagoon is one of the recreational sites along the Jeddah coast, showing the environmental impacts of urbanization along the coast. A sediment core (220 cm) was collected from the intertidal zone to evaluate the heavy metals (Fe, Mn, Cr, Ni, Cu, Zn, and Pb) and geochemical indices (contamination factor, geo-accumulation index, and pollution load index). In the organ-ic-rich muddy sediments (0–100 cm), there is a high metals content and a pollution load index of ~3, indicting anthropogenic impacts with high Cu contamination (CF:12) and moderate Fe, Mn, Cr, Ni, Zn, and Pb contamination (CF: <3). The organic matter and heavy metals washed through surface run-off from the land and deposited as urban waste. Down the core, consistent metals concentration, CF, and Igeo trends indicate a common pollutant source and pollution load variations over time. In the sediment section (70–40 cm), a high organic matter, metal concentration, CF, Igeo, and PLI value (≥5) suggest an uncontrolled pollution load. The decreased and stable trends of environmental indicators toward surface sediments suggest measures taken to control the pollution along the Jeddah coast. Below 110 cm, the carbonate-rich sediments have low organic matter and metals, showing an unpolluted depositional environment. The negative geo-accumulation index implies a geogenic source and indicates no anthropogenic impacts as inferred from low (~1.0) CF and PLI.
Experimental Study on the Influence of Bulbous Bow Form on the Velocity Field around the Bow of a Trimaran Using Towed Underwater 2D-3C SPIV
Authors: Deng Rui , Wang Shigang , Luo Wanzhen , Wu Tiecheng
Published: August 2021

In this study, particle image velocimetry was applied to measure the flow field around the bow region of a trimaran with different appendages. The dimensionless axial velocity u/U in test planes 1 and 2 of the testing model was measured by using a towed underwater stereoscopic particle image velocimetry (SPIV) system. Based on the measured flow field data, the local sinkage values in test planes 1 and 2 of the testing model with different appendages at speeds of 1.766 and 2.943 m/s were presented. In addition, the effects of speed, bulbous bow type, T foils, and bow wave on the axial velocity u/U were studied in detail. The acquired experimental data help in understanding the distribution of the flow field around the ship bow, and the data can also act as a reference to verify computational fluid dynamics (CFD) results.
Using Cloud-Based Array Electromagnetics on the Path to Zero Carbon Footprint during the Energy Transition
Authors: Strack Kurt , Davydycheva Sofia , Passalacqua Herminio , Smirnov Maxim , Xu Xiayu
Published: August 2021

Fluid imaging is one of the key geophysical technologies for the energy industry during energy transition to zero footprint. We propose better Cloud-based fluid distribution imaging to allow better, more optimized production, thus reducing carbon dioxide (CO2) footprint per barrel produced. For CO2 storage, the location knowledge of the stored fluids is mandatory. Electromagnetics is the preferred way to image reservoir fluids due to its strong coupling to the fluid resistivity. Unfortunately, acquiring and interpreting the data takes too long to contribute significantly to cost optimization of field operations. Using artificial intelligence and Cloud based data acquisition we can reduce the operational feedback to near real time and even, for the interpretation, to close to 24 h. This then opens new doors for the breakthrough of this technology from exploration to production and monitoring. It allows the application envelope to be enlarged to much noisier environments where real time acquisition can be optimized based on the acquired data. Once all components are commercialized, the full implementation could become a real game changer by providing near real time 3-dimensional subsurface images in support of the energy transition.
An Exact Algorithm for Task Allocation of Multiple Unmanned Surface Vehicles with Minimum Task Time
Authors: Xue Kai , Huang Zhiqin , Wang Ping , Xu Zeyu
Published: August 2021

Task allocation of unmanned surface vehicles (USVs) with low task cost is an important research area which assigns USVs from starting points to different target points to complete tasks. Most of the research lines of task allocation are using heuristic algorithms to obtain suboptimal solutions to reduce both the max task cost and total task cost. In practice, reducing the maximum is more important to task time, which is from the departure of USVs to the last USV arriving at the designated position. In this paper, an exact algorithm is proposed to minimize the max task time and reduce the total task time based on the Hungarian algorithm. In this algorithm, task time is composed of the travel time along the planned path and the turning time at initial and target points. The fast marching square method (FMS) is used to plan the travel path with obstacle avoidance. The effectiveness and practicability of the proposed algorithm are verified by comparing it with the Hungarian algorithm (HA), the auction algorithm (AA), the genetic algorithm (GA) and the ant colony optimization algorithm (ACO). The results of path planning and task allocation are displayed in the simulation.
Does Sand Beach Nourishment Enhance the Dispersion of Non-Indigenous Species?—The Case of the Common Moon Crab, Matuta victor (Fabricius, 1781), in the Southeastern Mediterranean
Authors: Zviely Dov , Zurel Dror , Edelist Dor , Bitan Menashe , Spanier Ehud
Published: August 2021

Sand beach nourishment (BN) is one of the commonest “soft solutions” for shore protection and restoration. Yet it may have ecological consequences. Can this practice enhance the introduction and dispersal of non-indigenous species (NIS)? There has been little research on the impacts of nourishment on NIS, especially in the southeastern Mediterranean, a region considered most affected by invading biota. However, so far only one study referred to the possible interaction between BN and the success of invading species. It reports increasing numbers and densities of the aggressive, omnivorous Indo-Pacific moon crab, Matuta victor (Fabricius, 1781) in Haifa Bay (northern Israel) between 2011 and 2017. This research suggests a possible role of anthropogenic disturbance in the outbreak of M. victor and blames the Israel Ministry of Environmental Protection for authorizing a (rather small scale) BN in Haifa Bay in 2011 as an alleged cause for this outbreak. Circumstantial indirect evidence is not sufficient to establish the role of nourishment in promoting the establishment and dispersal of NIS. There are plenty of examples of successful settlement and rapid and large-scale distribution of NIS (including another member of the genus Matuta), especially in the eastern Mediterranean, without any BN in the region. Furthermore, the location where the M. victor specimens were sampled was exposed to more prevailing and frequent anthropogenic marine stressors than BN, such as eutrophication, pollution, fishing activities and particularly port construction. To firmly establish an assumed role of nourishment in the invasion of NIS, assessments must be based on solid and orderly planned scientific research to be designed well before the beginning of any BN. It is suggested that direct communication between environmental regulators and scientists is crucial for improving both scientific research and environmental management policies.
Analysis of Ship Noise Characteristics Generated According to Sailing Conditions of the G/T 1000-ton Stern Fishing Trawler
Authors: Lee Tae-ho , Lee Nam-u , Lee Dae-jae , Jung Bong-kyu
Published: August 2021

In this study, we conducted onboard noise measurement experiments under the conditions of anchoring, sailing, casting, and hauling to determine whether noise generated in the G/T 1000-ton fishing trawler triggers zone-specific effects upon vessel operation. It was shown that most accommodation areas of the trawler comfortably met the IMO acceptance criteria regardless of the sailing condition, but most of the stern area, where the fishing actually occurs, exceeded the permitted limit of 75 dB (A). Furthermore, the statistical analysis revealed a significant difference (p < 0.05) only in the bow and the stern, which are both open areas. In the case of the former, improvements were deemed possible due to the influence of the fluid emission noise from the seawater piping in the bow, and the acceptance criteria were also appropriate. However, in the case of the latter, a significant difference was seen in hauling conditions, and on-site analysis confirmed frictional noise from hydraulic oil in the trawl winch and between the chains and the metal hull, leading to the conclusion that various improvements are required, such as the mandatory wearing of safety equipment by workers and stricter legal standards for permitted noise levels.
Epidemiology of Candidemia in Kuwait: A Nationwide, Population-Based Study
Authors: Alobaid Khaled , Ahmad Suhail , Asadzadeh Mohammad , Mokaddas Eiman , Al-Sweih Noura , Albenwan Khalifa , Alfouzan Wadha , Al-Obaid Inaam , Jeragh Ahlam , Al-Roomi Ebtihal , Khan Ziauddin , Joseph Leena , Varghese Soumya
Published: August 2021

The Candida species cause a majority of invasive fungal infections. In this article, we describe the nationwide epidemiology of candidemia in Kuwait in 2018. Yeast bloodstream isolates submitted from all major hospitals and identified by phenotypic MALDI-TOF MS and/or by molecular methods were studied. Susceptibility testing was performed by Etest. Out of 313 bloodstream yeasts, 239 Candida spp. isolates (excluding duplicate isolates) were obtained during 234 candidemic episodes among 223 patients. Mixed-species candidemia and re-infection occurred in 5 and 11 patients, respectively. C. albicans (n = 74), C. parapsilosis (n = 54), C. tropicalis (n = 35), C. auris (n = 33), C. glabrata (n = 32), other Candida spp. (n = 11), and other yeasts (n = 9) caused fungemia. Nearly 50% of patients were in intensive care units. Candida spp. isolates (except C. glabrata) were susceptible to caspofungin and 27% of C. auris were amphotericin B-resistant. Resistance to fluconazole was 100% in C. auris, 17% in C. parapsilosis, 12% in C. glabrata, and 1% in C. albicans. Mortality was 47% for other Candida/yeast infections. Nationwide candidemia incidence in 2018 was 5.29 cases/100,000 inhabitants. Changes in species spectrum, increasing fluconazole resistance in C. parapsilosis, and the emergence of C. auris as a major pathogen in Kuwait are noteworthy findings. The data could be of help in informing decisions regarding planning, in the allocation of resources, and in antimicrobial stewardship.