bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Association between Genetic variant rs5925 in LDLR Gene and the Incidence of T2DM with CAD in Iraqi Population. A case-control Study
Authors: Salman Mohammed N , Al-Kashwan Thekra Abid Jaber , aljanabi Abdulhussein Faraj Alwan
Published: August 2023

Background
The crucial function of the low-density lipoprotein receptor (LDLR) is to regulate cellular cholesterol levels. Changes in the LDLR gene can result in a notable rise in LDL cholesterol in the blood, potentially increasing the likelihood of T2DM with CAD, which involves atherosclerosis and coronary heart problems. Additionally, it impacts lipid levels in the bloodstream among Iraq's population. This study primarily aimed to explore the possible link between the LDLR rs5925 variation and cardiovascular disease (CVD) in individuals with type 2 diabetes in Iraqi population.
Method
The research involved a sample of 400 participants, categorized into two groups: 200 individuals with both Type 2 Diabetes Mellitus (T2DM) and coronary artery disease, and 200 healthy individuals without these medical conditions. The main objective of the investigation was to explore the potential link between a specific variation in the LDLR gene known as rs5925 and the susceptibility to these ailments. To achieve this, a logistic regression analysis was conducted to determine odds ratios (OR) and their corresponding 95% confidence intervals (CI). In this instance a case-control study employed the Allele Discrimination/SNP's Real-Time PCR TaqMan technique, utilizing the Mx3005P QPCR System to genotype the polymorphism.
Result
In the analysis of the frequencies of the LDLR gene polymorphism, rs5925 T/C, using the co-dominant model, it was observed that individuals affected by both Type 2 Diabetes (T2DM) and coronary artery disease (CAD) showed a notable increase in heterozygous genotype (TC) compared to the control group (adjusted odds ratio [OR] = 3.2, 95% confidence interval [CI] = 2.03–4.9, p < 0.0001). Additionally, it is worth noting that the homozygous recessive genotype (CC) also demonstrated a significant increase when compared to the control group (OR = 10.5, CI 95% = 2.6–6.1, p < 0.01). These findings suggest that individuals with the genotypes (TC) may be three times higher risk of developing Type 2 Diabetes (T2DM) along with coronary artery disease (CAD) compared to those with the wild type genotype (TT) as well as (CC) may be at nearly ten times.
Conclusions
This study is the inaugural instance of showing a link between the LDLR gene polymorphism and a heightened vulnerability to cardiovascular disease among patients with type 2 diabetes. The results of our study indicate an association between the variation in the LDLR gene rs5925 and the occurrence of both T2DM and CAD, also impacting lipid profiles.
Some New Copson-Type Inequalities on Time Scales Delta Calculus
Authors: Ahmed A. M. , Saied A. I. , Rezk H. M.
Published: August 2023

In this research, we establish some new generalizations of dynamic inequalities of Copson-type on time scales delta calculus by applying Hölder’s inequality, Minkowski’s inequality, chain rule and the properties of power rules on time scales. As special cases of our results (when T = R), we get the continuous analouges of inequalities that proved by Mohapatra and Vajravelu [8] and when T = N 0 , the results to the best of the authors’knowledge, are essentially new. 2010 Mathematics Subject Classi…cation: 26D10, 26D15, 34N05, 47B38, 39A12.
RETRACTED: Evolution in medical education: Perception of evolution among medical students and resident training doctors in Turkey
Authors: Şahin Mustafa Emre , Kaya Ferah Diba , Oral Dilan , Düzova Halil , Günbayı İlhan , Çıplak Battal
Published: August 2023

The authors have requested that this preprint be removed from Research Square.
Unveiling the oncogenic role of lncRNA 91H in liver Cancer: Implications for proliferation, migration, invasion, and epithelial-mesenchymal transition
Authors: Mo Zhiyuan , Wang Zhuangqiang
Published: August 2023

Objective
This study aimed to investigate the functional role of long ncRNA (lncRNA) 91H in liver cancer tumorigenesis, focusing on its effect on cell proliferation, apoptosis, cell cycle progression, migration, invasion, and epithelial-mesenchymal transition (EMT).
Methods
Liver cancer tissues and cell lines were analyzed for lncRNA 91H expression using quantitative methods. The functional role of 91H was assessed by silencing its expression in liver cancer cells. Cell proliferation was evaluated by measuring apoptosis induction and cell cycle progression. The migration and invasion capabilities of liver cancer cells were assessed and their impact on EMT was examined.
Results
Significantly higher levels of lncRNA 91H were observed in liver cancer tissues and cell lines than in normal cells. Silencing of 91H in liver cancer cells led to a notable reduction in cell proliferation by inducing apoptosis and arresting the cell cycle. Liver cancer cells with decreased 91H expression exhibited diminished migration and invasion abilities, suggesting a role for 91H in promoting these processes. Furthermore, 91H knockdown weakened EMT in liver cancer cells, indicating its involvement in modulating this critical cellular transition.
Conclusion
The findings of this study demonstrated that lncRNA 91H plays an oncogenic role in liver cancer. Its overexpression in liver cancer tissues and cell lines is associated with increased proliferation, migration, invasion, and EMT. Silencing 91H resulted in the inhibition of cell proliferation and reduced metastatic potential, suggesting its potential prognostic and therapeutic value in liver cancer. Further exploration of the molecular mechanisms underlying the involvement of 91H may provide valuable insights into liver cancer progression, and contribute to the development of more effective therapeutic strategies.
Exploratory laparotomy diagnostic and management mainstay in a case of huge ovarian cyst torsion on late post postpartum period, at resource limited set up of leku general hospital,sidama,Ethiopia, case report
Authors: Kibret Asfaw , Bayu Efrem
Published: August 2023

Background: Huge ovarian cyst is a rare occurrence in postpartum period. Once existing ovarian cyst passes the pregnancy period, it is a risk for torsion on postpartum days when the gravid uterus involuted.Here we present a case of huge ovarian cyst torsion on late post partum period which is diagnosed and managed in our resource limited set up.
Case presentation: this is a case of 30yrs old female patient who is on her 30th post partum date after she gave alive fetus at home. Then she noticed that her abdomen failed to decrease after delivery and waited for spontaneous decrement and lastly she visited health center for the newly developing worsened pain since last 3 days of her presentation to health center.
Conclusion: This case reports that huge ovarian cyst accompanied pregnancy might not affect the pregnancy and vaginal delivery is possible but torsion is common in this case due to the involution of the postpartum uterus. Exploratory laparotomy in low resource set up is still the main stay for diagnosis and management of such emergency cases.
Effect of exposure to ambient air pollution on gynecological cancer: A systematic review
Authors: Murithi Rachael Gakii , Lu Chan
Published: August 2023

Background
The importance of gynecological cancer and air pollution awareness cannot be overemphasized. Various studies undertaken worldwide have found that exposure to atmospheric pollutants can lead to high morbidity and mortality due to gynecological cancer. Hence, it is critical to address this issue for the prevention and reduction of gynecological cancers.
Objective
This review was conducted to objectively assess the effect of exposure to ambient air pollution on gynecological cancer and its related factors among women.
Methods
A systematic review and meta-analysis of quantitative research were conducted. We searched 5 electronic databases: CINAHL (EBSCO Academic Search Premier); Google Scholar; Embase; PubMed and Web of Knowledge to identify relevant studies for inclusion from January 2011 to December 2021. The quality of each study included for meta-analysis was determined using the Joanna Briggs Institute Critical appraisal tool.
Results
18,324 records were identified from the electronic data search. 16,535 records were filtered systematically. Finally, 12 studies involving 5 population-based cross-sectional studies using secondary data from demographic health surveys conducted prior, 2 cohort studies, 3 articles are case-control studies, 1 ecological study, and 1 meta-analysis were added in the final analysis. Accordingly, the overall point estimate of gynecological (cervical, ovarian, and endometrial) cancer among women worldwide was 50% (95%CI: 43 ~ 57%). High heterogeneity (I2 = 99.72%, p < 0.001) was noticed which could be due to factors not explored in this review. The factors commonly associated with gynecological cancer were occupation, procreation, age, diabetes, the number of births, drinking, a family history of cancer, menstrual cycle, and environmental tobacco smoke (ETS).
Conclusion
Long-term air pollution exposure has a significant impact on the occurrence and development of gynecological tumors. The interaction between ambient air pollution and sensitive determinants can significantly increase the risk of gynecological tumors. Air pollution exposure may be high in most countries worldwide. Hence, there was heterogeneity in the effect of exposure to ambient air pollution on gynecological cancer.
An Intelligent Camera Based Eye Controlled Wheelchair System: Haar Cascade and Gaze Estimation Algorithms
Authors: v viswanatha , A.C Ramachandra , Reddy Gowkanapalli Lokeshwar , Reddy A V Sai Tharun , Reddy Biyyam Pranay Kumar , Kiran Gavvala Bhanu
Published: August 2023

This article proposes a system that aids people
with disabilities. An Electric Eye Controlled Wheelchair System
is built to help disabled people. With the designed system,
disabled people can move effortlessly without support from
others. The system uses image acquisition wherein the image of
the eye is processed to find out the gaze direction of the eye using
Haar cascade and gaze estimation algorithms and hence
wheelchair moves according to the direction of eyeball
movement. The gaze estimation algorithm is so precise and one
single algorithm does the job of what two algorithms (Canny
Edge detection, Hough Transform) are supposed to do and to
execute the same task. With this technique, a disabled person
can steer their wheelchair with their eye movement. The
webcam is placed in Infront of the person which captures the
live movements, and an image processing technique is used to
track the position of the pupil in both eyes with the help of a
raspberry pi processor. The image processing technique used
here is Gaze tracking which uses Open CV. The gaze tracking
tracks pupil movement and depicts its coordinates. According to
pupil motion, the motor driver will be instructed to go forward,
left, and right. A blink instruction is used to stop the wheelchair
when the person blinks. Additionally, a front-mounted
ultrasonic sensor that can detect obstructions and automatically
halt wheelchair movement is mounted for safety reasons. The
system is monitored by a Raspberry Pi device, which lowers the
cost.
A Model for the Formation of Heavy Lepton Masses
Authors: Kosik D.W.
Published: August 2023

A simple model is given for the delivery of energy in the formation process of a heavy charged lepton that leads to a good approximation of the heavy lepton masses and the origin of lepton generations. An estimate of neutrino masses is also given via the same model.
Professores: Somos resistência, nossa voz precisa ser grito
Authors: De Oliveira Nara Rosane Machado , Brizolla Francéli , Martins Claudete Silva Lima
Published: August 2023

Este trabalho tem por objetivo apresentar reflexões de professores do Ensino Médio e de suas práticas pedagógicas junto a jovens de Ensino Médio de uma escola pública de periferia, práticas estas consideradas como resistência diante do contexto político educacional atual. Buscou-se, assim, investigar os processos de resistência utilizados por professores desta escola, a partir de uma pesquisa de campo desenvolvida com um grupo de 14 professores de diversas áreas do conhecimento, por meio dos pressupostos metodológicos da sociopoética. Suas reflexões são de evidente contribuição para a compreensão do quanto teremos, iremos e resistiremos. Concluímos que a Educação, para quem tem poucas condições financeiras ou não pertence ao “grupo escolhido” para “ser alguém na vida”, é o maior ato de rebeldia que pode ser cometida por um jovem pobre, e que este ato de rebeldia é a manifestação da luta e resistência de professores que têm seus pés firmes no chão, que representam a escola e que acreditam no poder da oportunidade e da possibilidade libertadora que a educação é capaz de proporcionar.
O pensamento de Robert Merton sobre o desenvolvimento do conhecimento e da ciência: A sociologia da ciência
Authors: Massoni Neusa Teresinha , Moreira Marco Antonio
Published: August 2023

Este artigo tem o objetivo de apresentar e refletir algumas das principais ideias de Robert Merton, que é considerado por inúmeros pesquisadores como sendo o “pai da Sociologia da Ciência”. Os estudos sociológicos de Merton tomam a ciência como uma atividade social distintiva e detentora de um ethos característico. Vários desses estudos iniciaram na primeira metade do século 20, contudo, a leitura reflexiva de algumas de suas principais obras e artigos permite mostrar que muitas de suas ideias se mantêm atuais e nos ajudam a compreender como o apoio à ciência é assegurado por condições culturais apropriadas, porque é importante examinar aqueles controles que motivam carreiras científicas e que selecionam e prestigiam determinadas disciplinas científicas e rejeitam outras. Queremos crer que este trabalho possa suscitar interessantes discussões críticas em sala de aula da Educação Básica, auxiliando na transformação de concepções ingênuas e enraizadas sobre o fazer científico.
A voz docente na construção do currículo escolar
Authors: Felício Helena Maria dos Santos , Moraes Amanda Souza
Published: August 2023

Neste trabalho busca-se analisar o processo de participação dos professores na construção do currículo escolar. Fundamentado nas contribuições de Giroux (1988), Apple (2006) e Sacristán (2013) que apontam para a centralidade dos professores no desenvolvimento do currículo escolar e respaldado pelos pressupostos da pesquisa qualitativa, utilizou-se de entrevistas semiestruturada com professores da Educação Infantil e anos iniciais do Ensino Fundamental. As informações analisadas a partir do enfoque construtivo interpretativo expressam as significações predominantes para esses profissionais, as quais evidenciam um déficit na valorização e promoção de espaços para o diálogo, no que diz respeito à voz do professor nesta construção do currículo, limitando as possibilidades de participação e a autonomia, o que justifica a importância de um trabalho que avance na conquista de uma maior participação dos professores nos processos decisórios escolares.
Mulheres na ciência: Uma análise sistematizada dos artigos científicos publicados no Brasil pós-década de 1990
Authors: Motta Janayna , De Carvalho Fiúza Ana Louise
Published: August 2023

A história das mulheres nas ciências foi marcada por uma posição segregada e hierarquizada. O campo científico, constituído mediante uma visão social de mundo, lhes é contraditório em relação à suposta objetividade masculina exigida pela Ciência. Mas, como a participação das mulheres tem sido retratada nas produções científicas? Partindo deste questionamento, o objetivo proposto foi mapear como os trabalhos acadêmicos têm abordado a temática das mulheres nas ciências. Para tanto, este artigo possui um caráter metodológico qualitativo, no qual se buscou analisar e discutir as principais temáticas referentes às mulheres na produção científica. Optou-se, como procedimento metodológico, o uso da revisão bibliográfica sistematizada e do software de análise textual Iramuteq. Desta forma, foi possível verificar que as explicações para as assimetrias de gênero no campo científico se construíam por argumentos voltados aos seus aspectos sociais e históricos.
Ensino híbrido com metodologias ativas: Um mapeamento sistemático sobre o impacto na educação básica e superior
Authors: Müller Laura Teresa , Scotti do Canto-Dorow Thais
Published: August 2023

A pandemia causada pela Covid-19, e o consequente Ensino Remoto Emergencial instituído, acelerou o processo de discussão sobre o potencial do Ensino Híbrido e das Metodologias Ativas, com vistas à transformação dos modos de ensino-aprendizagem até então assentados e à busca por respostas para as seguintes questões: “Como resgatar o interesse dos alunos por aprender?” e “Como garantir uma aprendizagem significativa que, de fato, proporcione a formação de cidadãos reflexivos e protagonistas da sua aprendizagem?”. É nesse contexto que se propõe a realização do presente Mapeamento Sistemático (MS), com o objetivo de identificar estudos primários desenvolvidos em âmbitos nacional e internacional, que investigam como o Ensino Híbrido e as Metodologias Ativas estão sendo viabilizados no contexto educacional, tanto na educação básica quanto na superior, averiguando o impacto no processo de ensino-aprendizagem. A análise permitiu identificar que o Ensino Híbrido e as Metodologias Ativas impactam em diferentes dimensões no processo de ensino-aprendizagem, relacionadas a aspectos intrínsecos e extrínsecos, apresentando-se como uma possibilidade para responder às questões inicialmente elencadas. O presente trabalho disponibiliza à comunidade acadêmica e científica um levantamento abrangente das pesquisas e dos relatos de experiência, apontando as lacunas existentes e direcionando para novos esforços de estudos e práticas educacionais.
Alfabetização e letramento na educação infantil: A perspectiva da criança
Authors: Brandelero Camargo Gisele , Carvalho Serzoski Ana Claudia
Published: August 2023

Trata-se de uma pesquisa, realizada por ocasião da conclusão de curso, cujo objetivo visava a compreender a perspectiva das crianças acerca das atividades de alfabetização e letramento, realizadas na Educação Infantil. Nota-se, nos últimos anos da Educação Infantil, que há uma expectativa, das professoras, pais, gestores educacionais, em enviar as crianças para os Anos Iniciais do Ensino Fundamental com conhecimentos de leitura e escrita. Por isso, as práticas de alfabetização e letramento acabam se tornando comuns nas turmas de pré-escola da Educação Infantil. Considerando-se isso, com base na Sociologia da Infância (SARMENTO, 2003, 2005, 2013) realizou-se uma pesquisa com as crianças, entendendo-as como sujeitos competentes, produtores de conhecimento e cultura. Em uma abordagem qualitativa, na produção de dados com as crianças, foram propostas atividades baseadas em métodos tradicionais e construtivistas de alfabetização e letramento (SOARES, 2004, 2017; FERREIRO, TEBEROSKI, 1985), e entrevistas-conversa (SARAMAGO, 2001) com os sujeitos da investigação. As categorias de análise dividiram-se em duas: perspectivas das crianças sobre as atividades tradicionais e perspectivas das crianças sobre as atividades construtivistas. Os resultados da análise dos dados indicaram que as atividades construtivistas, pautadas na ludicidade, como jogos e brincadeiras, são indicadas pelas crianças e se tornam eficientes para inseri-las no mundo letrado, pois respeitam as lógicas infantis, valorizam a participação da criança e de suas diferentes formas de expressão e comunicação.
Objetos virtuais de aprendizagem como recurso pedagógico na educação ambiental: Um mapeamento dos repositórios institucionais
Authors: De Oliveira Felícia Maria Fernandes , Bizerra Ayla Márcia Cordeiro
Published: August 2023

Os Objetos Virtuais de Aprendizagem (OVA) são uma importante ferramenta tecnológica para ser utilizada pelos professores no ensino das mais diversas disciplinas, podendo configurar-se como potenciais recursos pedagógicos de aprendizagem. Algumas áreas, entretanto, podem ser menos contempladas por esta ferramenta, como é o caso da educação ambiental associada ao conhecimento químico. Assim, a presente pesquisa tem como objetivo analisar os Objetos Virtuais de Aprendizagem relacionados ao ensino de educação ambiental integrados ao conhecimento químico que estão disponíveis em nove repositórios, a fim de verificar sua potencialidade como recursos pedagógicos de aprendizagem. Neste sentido, trata-se de uma pesquisa exploratória descritiva, em que foi realizado um levantamento sobre os OVAs relacionados à educação ambiental, os quais foram caracterizados quanto aos aspectos reusabilidade, interoperabilidade, acessibilidade, interatividade, granularidade, adaptabilidade, flexibilidade, multimodalidade e autonomia para serem usados como recursos pedagógicos. Ao todo, foram encontrados 27 OVAs que podem ser utilizados para o ensino de educação ambiental integrada ao conhecimento químico. Contatou-se, portanto, que, quantitativamente, ainda são poucos os OVAs que relacionam os conceitos químicos com as temáticas ambientais. As análises realizadas indicam, no entanto, que a concepção de tecnologias puramente mecânicas embutida nesses objetos é superada, pois satisfaz as características técnicas e pedagógicas para serem consideradas potenciais recursos de aprendizagem.
É possível prevenir a violência? Percepções de mulheres e homens usuários da estratégia saúde da família
Authors: Gutmann Victoria Leslyê Rocha , Silva Camila Daiane , Amarijo Cristiane Lopes
Published: August 2023

Este estudo teve como objetivo conhecer a percepção de mulheres e homens usuários da Estratégia Saúde da Família acerca da prevenção da violência. Trata-se de um estudo descritivo, qualitativo, realizado com 32 pessoas usuárias de oito Estratégias de Saúde da Família em um município localizado ao sul do Rio Grande do Sul. As informações foram coletadas por meio de entrevistas e analisadas posteriormente pelo software IRaMuTeQ. Os resultados evidenciaram que, por sua complexidade, a violência é de difícil prevenção, porém imprescindível. Entre as estratégias e atitudes para a prevenção, foram elencados o policiamento e as mudanças individuais de comportamento. Em relação aos serviços e leis, os participantes remeteram-se à polícia, à Delegacia Especializada de Atendimento à Mulher e à Lei Maria da Penha. As unidades de saúde e a Educação também foram citadas na prevenção da violência. Acredita-se que a pesquisa tornou possível pensar em ações e estratégias mais viáveis em relação ao enfrentamento e prevenção das situações de violência que, por respeitarem as demandas dos indivíduos, poderão ser mais eficazes e resolutivas.
Investigate accounting practices by binte biluhuta sellers
Authors: Thalib Mohamad Anwar , Paputungan Vindi , Monantun Widy Pratiwi , Ismail Ulvarien , Damiti Fatmawaty , Abdullah Faisal
Published: August 2023

Purpose - This study aims to investigate simple accounting practices focusing on earning income by binte biluhuta sellers based on the local wisdom values of the Gorontalo people.Method - This study uses an Islamic paradigm with an Islamic ethnomethodology approach. Futher, the study uses the qualitative approach through observation and interview, In addition, there are five data analysis stages: charity, knowledge, faith, revelation information, and courtesy.Result - The results of the study showed that sellers earned higher income during the holy month of Ramadan most of the time except pandemic (covid-19) and rainy season. Accounting for this income is conditional on the value of patience (sabari) and gratitude (mosukuru) to obtain blessed sustenance from Allah (The Almighty God).Implication - The results of this study presented the concept of income accounting by binte biluhuta sellers with local wisdom and Islamic religiosity values.Originality - This accounting study is the first to raise accounting practices by binte biluhuta sellers that are conditional on the local cultural and religious values of the Gorontalo people.
Intellectual, spiritual and material structural summit in the poetry of "My Heart" by Sami Awdal
Authors: ABDULMAJED Ala
Published: August 2023

The structure of the text proves its globalization in today’s literature, as its templates and linguistic cords fall into place. The present research revolves around sets of structures—a kind of structuralism—intellectual, spiritual and material structuralism that expands and deepens the scope of research. The intellectual structure at the moment of scrutiny falls into a circle of thought and closed discourse in which the philosophy revolves around each of the neutral ideas that reach the mind of the reader. And the horizons of the idea expand so that it is possible to reach the top of the structure from the prefix and the leading sentence to the last morpheme, from which the resonance of all the discourse units is created. The units struggle for the ability to coexist and the survival of the significance of ideas in that structure. The spiritual structuralism of a cognitive circle turns into a structure with hieroglyphs and imagery, in which the genius of the text writer appears in his choice of words and luminous ideas. Then the intellectual and spiritual cognitive discourse mix so that within a kind of carrier of the ideas of the heavenly text, we create a symbol from which is read national intellectual cognitive knowledge.
Molecular characterisation and potential pathogenicity analysis of Acanthamoeba isolated from recreational lakes in Peninsular Malaysia
Authors: Abdul Halim Rohaya , Mohd Hussain Rosnani Hanim , Aazmi Shafiq , Halim Hasseri , Ahmed Khan Naveed , Siddiqui Ruqaiyyah , Shahrul Anuar Tengku
Published: August 2023

The present study aims to identify the Acanthamoeba genotypes and their pathogenic potential in three recreational lakes in Malaysia. Thirty water samples were collected by purposive sampling between June and July 2022. Physical parameters of water quality were measured in situ while chemical and microbiological analyses were performed in the laboratory. The samples were vacuum filtered through nitrate filter, cultured onto non-nutrient agar and observed microscopically for amoebic growth. DNAs from positive samples were extracted and made to react with polymerase chain reaction using specific primers. Physiological tolerance tests were performed for all Acanthamoeba-positive samples. The presence of Acanthamoeba was found in 26 of 30 water samples by PCR. The highest rate in lake waters contaminated with amoeba was in Biru Lake (100%), followed by Titiwangsa Lake (80%) and Shah Alam Lake (80%). ORP, water temperature, pH and DO were found to be significantly correlated with the presence of Acanthamoeba. The most common genotype was T4. Temperature- and osmo-tolerance tests showed that 8 (30.8%) of the genotypes T4, T9 and T11 were highly pathogenic. The presence of genotype T4 in habitats related to human activities supports the relevance of this amoeba as a potential public health concern.
Coagulant dosage prediction in the water treatment process
Authors: Tochio Eloiza Laisla Lino , do Nascimento Bruno Cézar , Lautenschlager Sandro Rogério
Published: August 2023

Coagulation is an important water treatment step in a water treatment plant (WTP). Jar tests are performed to determine the required dose of coagulant; however, these tests are slow to be performed and do not give a response in real-time to changes in raw water quality that changes abruptly during the day. To overcome this limitation, this research developed artificial neural network (ANN) models, using full-scale WTP data that served to calibrate the model and then predict the coagulant dosage, considering raw water as data input, in compliance with the treated water quality parameters. The best model was able to predict the coagulant dosage with a mean squared error of 0.016 and a correlation coefficient equal to 0.872. These results corroborate to promote coagulant dosage automation in WTPs, making it clear that ANN models allow a faster response in dosage definition and reduce the need for human interaction in the process.
Performance evaluation of ANN and ANFIS models for estimating velocity and pressure in water distribution networks
Authors: Rashid Abu , Kumari Sangeeta
Published: August 2023

In this study, two artificial intelligence techniques: (1) artificial neural networks (ANNs) using different algorithms such as Lavenberg–Marquardt (LM), Bayesian Regularization (BR), and Scaled Conjugate Gradient (SCG) and (2) Adaptive Neuro-Fuzzy Inference System (ANFIS) are used to predict velocity and pressure for Gadhra (DMA-5) real water distribution network (WDN), East Singhbhum district of Jharkhand, India. In case 1, flow rate and diameter are used as independent variables to predict velocity. In case 2, elevation and demand are used as independent variables to predict pressure. 80% of the data are used to train, test, and validate the ANN and ANFIS prediction models, while 20% of the data are used to evaluate data-driven models. Sensitivity analysis is performed in ANN-LM to understand the relationship between the independent and dependent variables. The performance indices of RMSE, MAE, and R2 are evaluated for ANN and ANFIS for different combinations. The ANN-LM, with 2-16-1 architecture, is found as a superior to predict velocity and ANN-LM with architecture 2-17-1 is found as a superior to predict pressure. ANN-LM had the best prediction in estimating velocity (RMSE = 0.0189, MAE = 0.0122, R2 = 0.9568) and pressure (RMSE = 0.3244, MAE = 0.2176, R2 = 0.9773).
Good Manufacturing Practices for Quality and Safety Management in the Food Industry
Authors: SZCZYRBA A.
Published: August 2023

Abstract. The article presents a description of the design and implementation of the FMEA methodology in a food company dealing with the processing of vegetables and fruits, where it is used in combination with the HACCP system as a tool for ensuring product quality and as a means of improving the operational efficiency of the production cycle. The use of the FMEA method as support for HACCP in terms of safety and quality allowed for step-by-step analysis of the production cycle, provided additional knowledge about processes and ultimately positively influenced both the process and the product itself.
Understanding the Risk and Opportunities as Well as Performance Variance Associated with ESG Funds for the Future of Investors in India
Authors: Ray Priyajit
Published: August 2023

Environment, Social and Governance (ESG) is an evolving field where the investors can grow their long term capital by keeping environmental and social objectives intact such that it is done in a socially responsible way. The ESG market has also got several risks as well as opportunities which may affect the investor in the long run. The investors in the recent scenario has got new avenue for investment by taking care of the social and environmental aspectsand, thereby the ESG funds are increasing day by day and its value is also rising since its inception. Stakeholders are finding such socially responsible funds better than normal funds for investment at times which is urging the companies to go for sustainable reporting standards and to introduce more such ESG funds for the future of investors. Though the ESG funds and the companies associated with such funds have sustainable values, there is an inherent risk associated with ESG and there are future opportunities for the market which is not ignorable. Therefore, the researcher attempted to study and understand the risks and opportunities associated with ESG for the companies and investors in general, and furthermore to access the performance of such ESG funds in our country such that the investors can reap benefits out of it during choosing their portfolio. The researcher arrived at definite findings ascertaining the results of the study and based on that conclusion of the current study have been given by the researcher with several recommendations such that the market can evolve in future.
Analysis of Interpersonal Relationships of Social Network Users Using Explainable Artificial Intelligence Methods
Authors: Ustin Pavel , Gafarov Fail , Berdnikov Andrey
Published: August 2023

The emergence of the social networking phenomenon and the sudden spread of the coronavirus pandemic (COVID-19) around the world have significantly affected the transformation of the system of interpersonal relations, partly shifting them towards virtual reality. Online social networks have greatly expanded the boundaries of human interpersonal interaction and initiated processes of integration of different cultures. As a result, research into the possibilities of predicting human behavior through the characteristics of virtual communication in social networks has become more relevant. The aim of the study is: to explore the possibilities of machine learning model interpretability methods for interpreting the success of social network users based on their profile data. This paper uses a specific method of explainable artificial intelligence, SHAP (SHapley Additive exPlanations), to analyze and interpret trained machine learning models. The research is based on Social Network Analysis (SNA), a modern line of research conducted to understand different aspects of the social network as a whole as well as its individual nodes (users). User accounts on social networks provide detailed information that characterizes a user's personality, interests, and hobbies and reflects their current status. Characteristics of a personal profile also make it possible to identify social graphs - mathematical models reflecting the characteristics of interpersonal relationships of social network users. An important tool for social network analysis is various machine learning algorithms that make different predictions based on sets of characteristics (social network data). However, most of today's powerful machine learning methods are "black boxes," and therefore the challenge of interpreting and explaining their results arises. The study trained RandomForestClassifier and XGBClassifier models and showed the nature and degree of influence of the personal profile metrics of VKontakte social network users and indicators of their interpersonal relationship characteristics (graph metrics).
Design of a smart doorbell for a leader’s office with availability status notification and visitor recognition features
Authors: Nguyen Khac-Nguyen , Nguyen Chanh-Nghiem , Bui Huu-Danh , Tran Minh-Tuong , Lam Chanh-Nghia , Truong Quoc Bao , Nguyen Hoang Dung , Nguyen Chi Ngon
Published: August 2023

Smart doorbells have become a critical component of smart homes and modern offices. However, a smart doorbell, particularly designed for a leader’s office, has not been introduced. In this study, a smart doorbell is developed for a leader’s office. The system includes an application that allows availability status notification on the doorbell module and voice communication with the visitor from inside the office based on a private Wi-Fi network without an Internet connection to prevent the leader from potential privacy and security issues. It also features a live video capture of the visitor with face recognition by implementing a MobileNet model. In training and testing this model, 1,549 free face images of 125 people were augmented to generate training, validation, and testing datasets of 9,185, 2,500, and 5,000 face images, respectively. An additional authentication testing dataset of 1,068 AI-generated face images was also used to evaluate the system’s False Acceptance Rate (FAR). A high confidence level of 0.945 was selected for the developed MobileNet model to obtain zero FAR and high accuracy, recall, and F-score values of 0.960, 0.960, and 0.978, respectively. Therefore, the proposed doorbell could be used for an office leader, showing potential use for biometric authentication.
Effects of different plant growth regulators as the foliar application on growth and flower quality of potted rose (Rosa chinensis Jacq. cv. Nhung)
Authors: Pham Thi Phuong Thao , Le Van Hoa , Le Thanh Toan , Trinh Van Ban
Published: August 2023

This study was conducted to evaluate the different concentrations of Naphthalene acetic acid (NAA), Benzyladenine (BA) and Gibberellic acid (GA3­) as foliar applications on growth and flower quality of potted rose Nhung (Rosa chinensis Jacq. cv. Nhung). The experiment was constructed in a completely randomized design, that included seven treatments, such as control (sprayed water), NAA, BA and GA3 at two different concentrations of 25 and 50 ppm, in six replications, with one plant/pot for each replication. The chemical solutions were applied three times at an interval of fifteen days. The results revealed that some plant growth regulators increased the growth and flowering time of rose cv. Nhung. Using pre-harvest foliar sprays of NAA and BA at 25 and 50 ppm concentrations showed maximum bud diameter, flower diameter and flowering duration as compared with the control treatment. The concentration of  GA3 foliar application at 25 ppm increased plant growth (the height of flowering branches and Spad values) without affecting flower quality values and the flowering duration in comparison with the control treatment.
Agrobacterium-mediated transformation of Nang Thom Cho Dao, an indica rice variety
Authors: Nguyen Van Manh , Do Tien Phat , To Thi Truc Tam , Nguyen Van Toan , Huynh Ky
Published: August 2023

Agrobacterium-mediated transformation is the most efficient method to transfer gene of interest into the plant genome. However, the transformation efficiency of this method with indica rice varieties is still low and needs to be improved. In this study, the Agrobacterium-mediated method was used to transfer reporter genes into the Nang Thom Cho Dao, an indica rice variety. Different transformation parameters, such as selection to used hygromycin at concentrations of 0, 25, 30, 40, and 50 mg/L, bacterial density, and infected duration, were tested and optimized. The results showed that 30 mg/L of hygromycin was the most appropriate concentration for selecting transgenic callus in Nang Thom Cho Dao. In addition, the highest transformation efficiency of this Nang Thom Cho Dao rice cultivar was observed at the bacterial suspension density OD600nm of 0.1, the infected duration of 20 minutes, and the 3-day co-culture period. The presence and expression of transgenes were confirmed by gus staining and PCR with specific primers for hptII and gus genes. This transformation procedure should be used for further studies in genetic engineering of Nang Thom Cho Dao and other indica rice varieties.
Effects of Titanium Dioxide nanoparticles on salinity tolerance of rice (Oryza sativa L.) at the seedling stage
Authors: Pham Thuy Trang , Danh Bao Ngoc , Do Tan Khang
Published: August 2023

This study aimed to evaluate the effects of titanium dioxide nanoparticles on the salinity tolerance of rice. The effects of five nano titanium dioxide concentrations (0 mg/L, 25 mg/L, 50 mg/L, 75 mg/L, and 100 mg/L) on the physiological and biochemical parameters of rice were evaluated. The results showed that among three rice varieties (ST24, ST25, OM18), only ST25 grew in a better manner with the application of TiO2 nanoparticles and the optimal concentration of TiO2 nanoparticles was 50 mg/mL. It increased the shoot height by 20.07% and the survival rate of rice compared to the control. These growth-promoting effects were simultaneous with increased levels of chlorophyll, carotenoid and proline. The activities of antioxidant enzymes were improved. While activities of enzymes catalase and peroxidase increased significantly, no change in the activities of ascorbate peroxidase was observed. Finding of this study showed that titanium dioxide nanoparticles increased the salinity tolerance of rice by promoting the photosynthetic and anti-oxidative processes in rice seedlings.
The Peritoneal Membrane and Its Role in Peritoneal Dialysis
Authors: Morelle Johann , Lambie Mark , Öberg Carl M. , Davies Simon
Published: August 2023

A healthy and functional peritoneal membrane is key to achieving sufficient ultrafiltration and restoring fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function at the start of PD or changes over time on treatment influence dialysis prescription and outcomes, and dysfunction of the peritoneal membrane contributes to fluid overload and associated complications. In this review, we summarize the current knowledge about the structure, function, and pathophysiology of the peritoneal membrane with a focus on clinical implications for patient-centered care. We also discuss the molecular and genetic mechanisms of solute and water transport across the peritoneal membrane, including the role of aquaporin water channels in crystalloid versus colloid osmosis; why and how to assess membrane function using peritoneal equilibration tests; the etiologies of membrane dysfunction and their specific management; and the effect of genetic variation on membrane function and outcomes in patients treated with PD. This review also identifies the gaps in current knowledge and perspectives for future research to improve our understanding of the peritoneal membrane and, ultimately, the care of patients treated with PD.
A Study of Strategies for English Pragmatic Teaching in Senior High School under Core Competency
Authors: Xiaoyun Zhu
Published: August 2023

Pragmatic competence is an indispensable element of communicative competence, which is also one goal of core competencies. The introduction of the concept of core competency in General Senior High School English Curriculum Standards puts more emphasis on cultivating students’ pragmatic competence and on teachers’ input of pragmatic knowledge in English teaching. This paper begins with clarifying the theories of pragmatic competence and pragmatic failure by referring to other linguists’ explanations. Then, it briefly discusses the importance of pragmatic teaching in senior high school English classrooms. Finally, this paper proposes some feasible teaching strategies to promote high school students’ pragmatic competence.
Analysis of Cultivated Land in Maonan District, Maoming Based on RS and GIS
Authors: Feng Shujie , Wang Ruei-Yuan , Liu Haolong , Wang Yun-Shang
Published: August 2023

Food is the most basic human survival need, and cultivated land is the basis of food production. Thereby, monitoring and analysis of cultivated land is the premise and foundation of sustainable agricultural development. In this paper, Maonan District of Maoming City was taken as the research area. The object-oriented classification and cultivated land extraction were carried out by Landsat-8 remote sensing (RS) images, and then a confusion matrix and kappa coefficient were used to evaluate the accuracy of the cultivated land extraction results. The results show that the cultivated land in this area is decreasing. The extraction results of the confusion matrix and Kappa coefficient evaluation were accurate, and the Kappa coefficients of the three different periods were all higher than 0.6. Moreover, the main reasons for the decrease of cultivated land in the study area are population growth, socio-economic development, and the adjustment and change of agricultural structure.
Real-Time Event Detection in Social Media Streams using Stream Data Mining
Authors: Raviteja Mellacheruvu , Reddy Vanguru Venkata Varun Kumar , Aqibuddin Shaik , Nerusu Hareendra Sri Nag
Published: August 2023

Abstract: The need for real-time event detection has grown rapidly in the modern world of instantaneous information transmission through social media. In order to implement real-time event detection inside the dynamic environment of social media streams, this research article provides a ground-breaking framework that harnesses the power of stream data mining techniques. The combination of three different stream data mining algorithms—Sliding Window Analysis, Burst Detection using K-Means, and Agglomerative Hierarchical Clustering—allows us to tackle this problem. Together, these algorithms make it possible to extract important patterns, shedding light on how events arise inside social media streams. Utilizing cutting-edge stream data mining techniques, this study introduces a novel framework for real-time event detection within social media streams. The quick identification and monitoring of real-world events take on critical importance in the modern environment of rapid information dissemination through social media channels. The dynamic and high-velocity characteristics of social media data streams present difficulties for conventional event detection methodologies.
Siddha System of Medicine
Authors: Gannewar Ms. Gayatri V. , Tiwari Mr. Kundan J.
Published: August 2023

Abstract: Siddha is one of the ancient medical systems in India considered as the mother medicine of ancient Tamils/Dravidians in south India. Siddha system of medicine is as old as mankind and dominated the civilazation of the southern penisula of India .There are some people whom claim that Ayurveda is the oldest medical system, but from the research done with the help of available historical data, it is evident that Siddha system of medicine is much older and has more history than even Ayurveda .Not only is this system the oldest, this is the medical system with lots of specialities far outweigh the Ayurvedic medicine. Ayurveda, the traditional Indian medicine, remains the most ancient yet living traditions. Although India has been successful in promoting its therapies with more research and science-based approach, it still needs more extensive research and evidence base; increased side effects, lack of curative treatment for several chronic diseases like, cancer. Disorders of the Musculoskeletal system affect all ages and ethnic groups.it also the Coronavirus diseases 2019(COVID-19) pandemic cause by the severe Acute Respiratory syndrome coronavirus 2 (SARS-coV2) is a massive threat to public health word wide. India is a peninsula of herbal hub, in which Siddha system of medicine has flourished as an englightment in the field of Medicine. Currently medicinal plant have become the per amount source of drug discovery in research for treating diverse from of disease including Cancer. Food is the major source for serving the Nutritional needs but with growing modernization some traditional ways are being given up. This review gives an overview of the Ayurvedic system of medicine and its rule in traditional medicine in order to overview of the Medicine in order to overcome malnutrition and related disorders Siddha is a great subject and explains a reputed indigenous medical and health system.