bluuebunny/crossref_metadata_2025 huggingface dataset:
Randomized Phase II Trial of Bevacizumab or Temsirolimus in Combination With Chemotherapy for First Relapse Rhabdomyosarcoma: A Report From the Children’s Oncology Group
Authors: Mascarenhas Leo , Chi Yueh-Yun , Hingorani Pooja , Anderson James R. , Lyden Elizabeth R. , Rodeberg David A. , Indelicato Daniel J. , Kao Simon C. , Dasgupta Roshni , Spunt Sheri L. , Meyer William H. , Hawkins Douglas S.
Published: September 2019

PURPOSE

The primary aim of this clinical trial was to prioritize bevacizumab or temsirolimus for additional investigation in rhabdomyosarcoma (RMS) when administered in combination with cytotoxic chemotherapy to patients with RMS in first relapse with unfavorable prognosis.

PATIENTS AND METHODS

Patients were randomly assigned to receive bevacizumab on day 1 or temsirolimus on days 1, 8, and 15 of each 21-day treatment cycle, together with vinorelbine on days 1 and 8, and cyclophosphamide on day 1 for a maximum of 12 cycles. Local tumor control with surgery and/or radiation therapy was permitted after 6 weeks of treatment. The primary end point was event-free survival (EFS). Radiographic response was assessed at 6 weeks. The study had a phase II selection that was design to detect a 15% difference between the two regimens (α = .2; 1-β = 0.8; two sided test).

RESULTS

Eighty-seven of 100 planned patients were enrolled when the trial was closed after the second interim analysis after 46 events occurred in 68 patients with sufficient follow-up. The O’Brien Fleming boundary at this analysis corresponded to a two-sided P value of .058 with an observed two-sided P value of .003 favoring temsirolimus. The 6-month EFS for the bevacizumab arm was 54.6% (95% CI, 39.8% to 69.3%) and 69.1% (95% CI, 55.1% to 83%) for the temsirolimus arm. Objective response rates were 28% (95% CI, 13.7% to 41.3%) and 47% (95% CI, 31.5% to 63.2%) for the bevacizumab and temsirolimus arms, respectively ( P = .12) and, 28% of patients on bevacizumab and 11% on temsirolimus had progressive disease at 6 weeks.

CONCLUSION

Patients who received temsirolimus had a superior EFS compared with bevacizumab. Temsirolimus has been selected for additional investigation in newly diagnosed patients with intermediate-risk RMS.
Are National Comprehensive Cancer Network Evidence Block Affordability Ratings Representative of Real-World Costs? An Evaluation of Advanced Non–Small-Cell Lung Cancer
Authors: Cohen Joshua T. , Lin Pei-Jung , Sheinson Daniel M. , Wong William B. , Wu Ning , Yim Yeun Mi , Ramsey Scott D.
Published: September 2019

PURPOSE:

The National Comprehensive Cancer Network (NCCN) developed the Evidence Blocks framework to assess the value of oncology regimens. This study characterizes the relationship between real-world costs and NCCN affordability ratings (ARs) for advanced non–small-cell lung cancer (aNSCLC) treatments.

METHODS:

Using the MarketScan and PharMetrics Plus databases, we identified patients treated between 2012 and 2017 with an aNSCLC regimen evaluated by the NCCN Evidence Blocks. We estimated adjusted mean total per-patient-per-month (PPPM) costs and drug costs for each regimen using a log-linked gamma generalized linear model. Weighted regression was used to examine the correlation between adjusted mean PPPM costs per regimen and NCCN AR.

RESULTS:

A total of 25,162 patients with aNSCLC (mean age, 63 years [standard deviation, 10 years]; 52% male) had identifiable regimens. Mean total PPPM cost by therapeutic class ranged from $16,824 for epidermal growth factor receptors to $41,815 for immunotherapy-based treatment. Epidermal growth factor receptor and anaplastic lymphoma kinase inhibitor treatment had lower ARs compared with generic chemotherapy. No therapy was listed as AR group 5 (least expensive). In pairwise comparisons, AR group 1 had significantly higher PPPM total costs compared with AR groups 2 and 4. There were no significant differences in PPPM total cost among AR groups 2, 3, and 4.

CONCLUSION:

Real-world aNSCLC treatment costs are often inconsistent with the NCCN ARs. Given that NCCN Evidence Blocks are intended to inform provider-patient discussions and other decision support resources, such as the NCCN Categories of Preference, our results suggest that the NCCN ARs require further refinement and validation.
Opioids and Their Endocrine Effects: A Systematic Review and Meta-analysis
Authors: de Vries Friso , Bruin Mees , Lobatto Daniel J , Dekkers Olaf M , Schoones Jan W , van Furth Wouter R , Pereira Alberto M , Karavitaki Niki , Biermasz Nienke R , Zamanipoor Najafabadi Amir H
Published: September 2019

Context

The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects of opioids on other hypothalamo–pituitary–end organ hormone axes, remains unclear.

Objective

The aim of this systematic review and meta-analysis was to assess the effects of opioid use on pituitary function.

Methods

Eight electronic databases were searched for articles published up to May 8, 2018. Fixed or random effects meta-analysis was performed to estimate pooled proportions with 95% confidence intervals (CI). This study is reported following the PRISMA and MOOSE guidelines.

Data synthesis

52 studies (22 low risk of bias) were included describing 18 428 subjects, consisting of patients with chronic pain (n = 21 studies) or on maintenance treatment for opioid addiction (n = 9) and healthy volunteers (n = 4). The most frequently used opioid was methadone (n = 13 studies), followed by morphine (n = 12). Prevalence of hypogonadism was 63% (95% CI: 55%–70%, 15 studies, 3250 patients, 99.5% males). Prevalence of hypocortisolism relying on dynamic and nondynamic testing was 15% (95% CI: 6%–28%, 5 studies, 205 patients, 57.5% males) and including only studies using the insulin tolerance tests 24% (95% CI 16%–33%, 2 studies, n = 97 patients). In 5 out of 7 studies, hyperprolactinemia was present. No clear effects on the somatotropic and hypothalamo–pituitary–thyroid axes were described.

Conclusions

Hypogonadism occurs in more than half of male opioid users, and hypocortisolism in approximately one-fifth of all patients. Periodical evaluation of at least the gonadal and adrenal axes is therefore advisable.
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
Authors: Tsankov Alexander M. , Wadsworth Marc H. , Akopian Veronika , Charlton Jocelyn , Allon Samuel J. , Arczewska Aleksandra , Mead Benjamin E. , Drake Riley S. , Smith Zachary D. , Mikkelsen Tarjei S. , Shalek Alex K. , Meissner Alexander
Published: September 2019

Maintenance of pluripotency and specification towards a new cell fate are both dependent on precise interactions between extrinsic signals and transcriptional and epigenetic regulators. Directed methylation of cytosines by the de novo methyltransferases DNMT3A and DNMT3B plays an important role in facilitating proper differentiation, whereas DNMT1 is essential for maintaining global methylation levels in all cell types. Here, we generated single-cell mRNA expression data from wild-type, DNMT3A, DNMT3A/3B and DNMT1 knockout human embryonic stem cells and observed a widespread increase in cellular and transcriptional variability, even with limited changes in global methylation levels in the de novo knockouts. Furthermore, we found unexpected transcriptional repression upon either loss of the de novo methyltransferase DNMT3A or the double knockout of DNMT3A/3B that is further propagated upon differentiation to mesoderm and ectoderm. Taken together, our single-cell RNA-sequencing data provide a high-resolution view into the consequences of depleting the three catalytically active DNMTs in human pluripotent stem cells.
Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes
Authors: Zoeller Elizabeth L. , Pedro Brian , Konen Jessica , Dwivedi Bhakti , Rupji Manali , Sundararaman Niveda , Wang Lei , Horton John R. , Zhong Chaojie , Barwick Benjamin G. , Cheng Xiaodong , Martinez Elisabeth D. , Torres Matthew P. , Kowalski Jeanne , Marcus Adam I. , Vertino Paula M.
Published: September 2019

Collective invasion, the coordinated movement of cohesive packs of cells, has become recognized as a major mode of metastasis for solid tumors. These packs are phenotypically heterogeneous and include specialized cells that lead the invasive pack and others that follow behind. To better understand how these unique cell types cooperate to facilitate collective invasion, we analyzed transcriptomic sequence variation between leader and follower populations isolated from the H1299 non-small cell lung cancer cell line using an image-guided selection technique. We now identify 14 expressed mutations that are selectively enriched in leader or follower cells, suggesting a novel link between genomic and phenotypic heterogeneity within a collectively invading tumor cell population. Functional characterization of two phenotype-specific candidate mutations showed that ARP3 enhances collective invasion by promoting the leader cell phenotype and that wild-type KDM5B suppresses chain-like cooperative behavior. These results demonstrate an important role for distinct genetic variants in establishing leader and follower phenotypes and highlight the necessity of maintaining a capacity for phenotypic plasticity during collective cancer invasion.
Determination of the Distribution of Ferric Chloro Complexes in Hydrochloric Acid Solutions at 298 K
Authors: Uchikoshi Masahito
Published: September 2019

Understanding the intrinsic nature of materials requires ultrahigh-purity materials because impurities affect various properties. Ion-exchange separation is one of the most promising purification technologies; however, the thermodynamic details of the ion-exchange reaction have not been made clear. The condition of metal species in the solution phase is fundamental to investigating the ion-exchange reaction. In this paper, the distribution of ferric chloro complexes in hydrochloric acid solutions was investigated by factor analysis of UV-Vis absorption spectra, followed by fitting analysis of a theoretical model to individual molar attenuation coefficients obtained by mathematical decomposition of UV-Vis absorption spectra. Five ferric species were detected by principal component analysis using a novel index proposed in this paper. In the results of factor analysis followed by fitting analysis, [FeIII]3+, [FeIIICl]2+, [FeIIICl2]+, [FeIIICl3]0, and [FeIIICl4]− were identified. The activity coefficients of charged species in concentrated aqueous solutions were estimated by using a modified Debye-Hückel equation. The thermodynamic parameters of the four cumulative formation constants and a Setchénow coefficient for neutral species of [FeIIICl3]0 were determined. The adsorbability of ferric, cupric, and cobalt species to an anion exchanger from hydrochloric acid solutions was qualitatively discussed using the results obtained in this paper.
Carbon Dioxide Hydrosilylation to Methane Catalyzed by Zinc and Other First-Row Transition Metal Salts
Authors: Zhang Qiao , Fukaya Norihisa , Fujitani Tadahiro , Choi Jun-Chul
Published: September 2019

We accomplished zinc catalyzed hydrosilylation of carbon dioxide (CO2) to silyl formate (C+II), bis(silyl)acetal (C0), methoxysilane (C−II), and finally methane (C−IV). Among several zinc salts, we found that Zn(OAc)2 with ligand 1,10-phenanthroline was the best. A turnover number of 815000 was achieved using the zinc catalyst to yield C+II. Unexpectedly, we observed the generation of CO from CO2 and hydrosilane for the first time. In addition to Zn, other first-row transition metals (Mn, Fe, Co, Ni, and Cu) also served as Lewis acid catalysts for CO2 hydrosilylation, regardless of the nature of the metal.
Shared Genetics of Psychiatric Disorders
Authors: Fuller Tova , Reus Victor
Published: September 2019

Until recently, advances in understanding the genetic architecture of psychiatric disorders have been impeded by a historic, and often mandated, commitment to the use of traditional, and unvalidated, categorical diagnoses in isolation as the relevant phenotype. Such studies typically required lengthy structured interviews to delineate differences in the character and duration of behavioral symptomatology amongst disorders that were thought to be etiologic, and they were often underpowered as a result. Increasing acceptance of the fact that co-morbidity in psychiatric disorders is the rule rather than the exception has led to alternative designs in which shared dimensional symptomatology is analyzed as a quantitative trait and to association analyses in which combined polygenic risk scores are computationally compared across multiple traditional categorical diagnoses to identify both distinct and unique genetic and environmental elements. Increasing evidence that most mental disorders share many common genetic risk variants and environmental risk modifiers suggests that the broad spectrum of psychiatric pathology represents the pleiotropic display of a more limited series of pathologic events in neuronal development than was originally believed, regulated by many common risk variants and a smaller number of rare ones.
Rare health condition 27: Mayer-Rokitansky-Küster-Hauser syndrome; and the role of informal caregivers
Authors: Barber Chris
Published: September 2019

The purpose of this series is to highlight a range of rare health conditions. Rare health conditions are those that affect no more and usually less than 1 person in every 2000 and many HCAs and nurses will encounter some of these conditions, given the high number of them. This 27th article will explore one of these conditions—Mayer-Rokitansky-Küster-Hauser syndrome—and the role and support needs of the ‘informal’ family caregiver.
Person-Centred Dermatology Self-care Index: a translation and validation study
Authors: Kottner Jan , Ludwig Oliver , Bode Thomas , Cowdell Fiona , Ersser Steven , Blume-Peytavi Ulrike , Lahmann Nils
Published: September 2019

Objective:

Self-management is important to successfully managing chronic skin diseases. The Person-Centred Dermatology Self-care Index (PeDeSI) is a self-efficacy theory-based questionnaire tool to measure education and support needs of adults with long-term skin conditions. The aim of this research was to translate the PeDeSI into German (PeDeSI-G) and to explore the validity of this tool.

Methods:

The instrument was translated by five translators working independently. User understanding and relevance were evaluated by nurses, patients and physicians. The translated version was modified and applied in a subsequent validation study. Demographic and other variables, PeDeSI-G and Dermatology Life Quality Index (DLQI) scores of dermatological patients were obtained.

Results:

PeDeSi-G and DLQI scores were obtained from 100 patients. A conceptually and semantically equivalent German translation of the PeDeSI was developed. There was a statistically significant difference between in- and outpatients (p<0.001). PeDeSI-G scores were most strongly correlated with disease duration and DLQI scores.

Conclusions:

Validation results indicate that the PeDeSI-G is able to discriminate between patients with different educational and support needs for this patient group. Newly diagnosed patients and patients admitted to the hospital for the first time might benefit most from the PeDeSI-G assessment. The PeDeSI-G is a valid tool for assessing and evaluating the support needs of German-speaking patients with chronic skin disease.
Brief Report: Calculation and Convergent and Divergent Validity of a New ADOS-2 Expressive Language Score
Authors: Mazurek Micah O. , Baker-Ericzén Mary , Kanne Stephen M.
Published: September 2019

Despite the importance of expressive language for individuals with autism spectrum disorder (ASD), expressive language assessments are not consistently included in ASD research and many studies do not adequately describe participants' verbal abilities. A valid and efficient measure of expressive language would facilitate consistent reporting across ASD research studies and provide data for additional analyses. The current study developed a new Autism Diagnostic Observation Schedule (ADOS-2) expressive language score and examined convergent and divergent validity in a large, well-defined sample of children with ASD. This score was highly correlated with other measures of expressive language (including parent-report, direct assessment, and clinician ratings) and less strongly correlated with measures of receptive language and nonverbal cognitive ability, providing good evidence of convergent and divergent validity.
Behavioral Treatment of Self-Injury: 2001 to 2016
Authors: Shawler Lesley A. , Russo Samantha R. , Hilton Jennifer L. , Kahng SungWoo , Davis Cheryl J. , Dorsey Michael F.
Published: September 2019

Individuals diagnosed with intellectual and developmental disabilities (IDD) frequently exhibit self-injurious behavior (SIB). Previous research has examined the published literature on behavioral treatments of SIB from 1964–2000. Results suggested that these treatments were highly efficacious at decreasing SIB, particularly when based on the results of a functional assessment. The purpose of this review is to update, replicate, and extend the previous research. The current findings indicate an increase in studies reporting automatically maintained SIB as well as less efficacious treatments overall. Discussion of our conclusions and methods of SIB assessment and treatment are discussed, both as they relate to the previous review and for future directions.
Self-Reported Guilt Among Adult Siblings of People With Intellectual and Developmental Disabilities
Authors: Shivers Carolyn M.
Published: September 2019

As more siblings become responsible for their aging brothers and sisters with intellectual and developmental disabilities, it becomes increasingly important to understand these siblings' emotional needs, including potential negative emotions such as guilt. This study examined the presence and correlates of self-reported guilt among 1,021 adult siblings of people with intellectual and developmental disabilities. Respondents completed the Adult Sibling Questionnaire, a national survey examining characteristics of adult health, depression, and feelings of guilt. Over 50% of siblings reported feeling increased guilt. Siblings who experienced increased guilt (versus those who did not) experienced less close sibling relationships, more depressive symptoms, and lower levels of well-being. Siblings experiencing more guilt also had brothers/sisters with more severe emotional/behavioral problems.
Blur identification using image features
Authors: Bones P. J. , Millane R.P. , Bretschneider T.R.
Published: September 2019

A method for estimating the point spread function (PSF) of a remotely sensed image is extended. The technique developed is based on locating and measuring blurred linear features in the imagery and tomographically reconstructing the PSF. A form of blind deconvolution is applied to extract an estimate of the line spread function (LSF - equivalent to the projection of the PSF in the direction of the feature) from image features able to be modelled by a combination of two step functions. Two methods of performing the blind deconvolution are compared. A method for utilising the LSF estimates to provide an image quality metric is proposed.
A novel reconstruction method for weak-phase optical interferometry
Authors: Meimon Serge , Mugnier Laurent M. , Le Besnerais Guy
Published: September 2019

Current optical interferometers are affected by unknown turbulent phases. We account for this lack of phase information by introducing aberration parameters, and solve the image reconstruction problem by minimizing an original regularized criterion.
Regularization, support constraints, and noise reduction in images – a Cramér-Rao bound analysis
Authors: Matson Charles L. , Beckner Charles C.
Published: September 2019

Support constraints can result in noise reduction inside the support of images reconstructed by algorithms that employ deconvolution. The effects of regularization on this noise reduction are analyzed using a Cramér-Rao lower bound approach.
Nonlinear Reconstruction of Fizeau Fourier Transform Imaging Spectroscopy Data Cubes
Authors: Thurman Samuel T. , Fienup James R.
Published: September 2019

Fizeau Fourier transform imaging spectroscopy (FTIS) yields spectral image cubes with missing low spatial frequencies. These spatial frequencies are reconstructed from normal panchromatic imagery, a model for the missing data, and a nonlinear algorithm. Simulations show that the reconstruction process can dramatically improve the fidelity of Fizeau FTIS imagery.
Iterative Phase Retrieval in Phase-Space
Authors: Testorf Markus
Published: September 2019

Iterative phase retrieval methods are reinterpreted in terms of the Wigner distribution. A deterministic scheme is presented to apply phase retrieval algorithms developed for Fourier data to any first order optical system without change.
EDUCAÇÃO E GÊNERO: UMA DISCIPLINA COMPLEMENTAR DE GRADUAÇÃO
Authors: Paixão Márcia Eliane
Published: September 2019

Este artigo tem como foco o relato de experiência de uma DCG (Disciplina Complementar de Graduação) oferecida no Curso de Pedagogia Diurno, sendo aberta a toda comunidade estudantil da Universidade Federal de Santa Maria/RS. A temática de Gênero ainda não faz parte do currículo da Pedagogia e de poucas licenciaturas. No entanto, o tema está presente no dia a dia da Universidade e no cotidiano das Escolas da Educação Básica. Por conta disso, oferecer uma disciplina que possibilite a reflexão deste tema em diálogo com a educação tem se mostrado um espaço rico de estudos, de conhecimentos e de novas práticas. A intenção, aqui, é partilhar esta experiência prática no contexto de graduação a partir da narrativa desta atividade educativa em diálogo com a teoria feminista. Também dialogamos com Marie-Christine Josso e Jorge Larrossa em relação ao conceito de experiência. A DCG é ofertada todos os semestres, portanto é uma experiência em andamento, mas que já tem uma história para contar.
ESTUDOS DE GÊNERO NO CONTO TCHAU, DE LYGIA BOJUNGA: UMA PROPOSTA PARA AS AULAS DE LÍNGUA PORTUGUESA
Authors: Silva do Nascimento Stefany , José Silva dos Santos Odair
Published: September 2019

O artigo aqui apresentado tem o objetivo de discutir sobre a função do aluno, leitor em formação, no processo de leitura literária, compreendendo esse estudante como um elemento primordial para que haja a significação do texto literário lido em sala de aula. Para realização deste estudo, utilizamos as investigações da Estética da Recepção, nas vozes de Iser (1996; 1999) e Jauss (1994), estudiosos que postulam ideias fundamentais para o melhor entendimento do papel desempenhado pelo leitor. Nesse sentido, apresentamos um modelo de sequência didática produzida nos parâmetros de Cosson (2014), aplicando um estudo do conto Tchau (2014), de Lygia Bojunga, bem como as possíveis reflexões que podem surgir após sua aplicação em aulas de Língua Portuguesa.
VÍDEO MULHERES: UM ACONTECIMENTO PROBLEMATIZADO EM COTIDIANO EDUCATIVO
Authors: GOETTEMS LISIANE , Vione Schwengber Maria Simone
Published: September 2019

Os cotidianos educativos possibilitam aos sujeitos experimentarem modos detalhados, dialogados de ser e estar no mundo. Nesses espaços-tempos os acontecimentos envolvendo abordagens de gêneros encontram lócus de irrupção, deixando pistas para que pensemos sobre si e o Outro, em histórias plurais. O presente relato de experiências objetiva problematizar acerca dos processos de criação e socialização do vídeo Mulheres (2018), destinado a uma mobilização pedagógica com turmas do ensino superior. Recorre a metodologia S-IVAM, com aporte em Vilaça (2006) e segue as etapas de seleção, investigação e visões acerca do problema; elaboração da ação e das reflexões. A análise dos dados considera uma das nove narrativas que compõe a íntegra do audiovisual produzido, ancorada na categoria palavras e escutas às mulheres. Os resultados acenam importância aos acontecimentos de autoafirmação feminina, do direito a viver a palavra postada que diz de si mesma, de conquistar o lugar de fala como ato político.
MODY2 diagnostic issues in adults
Authors: Kononenko Irina V. , Glibka Anastasiya A. , Zubkova Natalya A. , Mayorov Alexander Y. , Tyulpakov Anatoly N. , Schmidt Olga M.
Published: September 2019

Approximately 90% of all cases of diabetes mellitus in adults involve type 2 diabetes, while the prevalence of maturity-onset diabetes of the young (MODY) remains undetermined leading to inappropriate treatment regimens. One of the most common monogenic forms of diabetes is a disease caused by a mutation in the glucokinase gene, MODY2. Knowledge of the clinical features of the disease allows the selection of patients with a high risk of mutation in the glucokinase gene and verification of diagnosis for molecular genetic research. This paper reflects the clinical features of MODY2 and the difficulties of diagnosis in adults. Furthermore, it presents a clinical case of a patient with MODY2 demonstrating all the features of this type of diabetes. A family member with a mutation in the gene allows to predict the nature of carbohydrate metabolism disorders in first degree relatives. A targeted study of only one part of the glucokinase gene in molecular genetic research is sufficient to confirm the diagnosis in relatives.
Diabetes mellitus, chronic pancreatitis and primary hyperparathyroidism: is there a connection?
Authors: Gorbacheva Anna M. , Zaytseva Nataliya V.
Published: September 2019

Hyperparathyroidism is a relatively frequent condition characterized by hypersecretion of parathyroid hormone. There are several forms of primary hyperparathyroidism. Each form affects its target region. In the visceral form, nephrocalcinosis, nephrolithiasis and peptic and duodenal ulcers are common. The pancreas is also a target organ. This article describes a clinical case of a patient with diabetes mellitus and previously treated primary hyperparathyroidism. The patient was admitted to the hospital due to poor glycaemic control. During the hospitalization, diabetes mellitus developed as a consequence of frequent relapses of chronic pancreatitis (outcome of the visceral form of primary hyperparathyroidism and severe hypertriglyceridemia). Glycaemic control was achieved after treatment of acute pancreatitis and insulin administration. This clinical case is an example of the impact of previous primary hyperparathyroidism (even after radical treatment and remission) on the development of a multi-faceted comorbidity.
Islam dan Resolusi Konflik
Authors: Harjuna Muhamad
Published: September 2019

AbstractThis article examines the essence of religion and specifically speaks of Islam as a peaceful, progressive and solutive religion. Islam comes from the Most Peaceful (al-Salâm), always spreading peace wherever and whenever. The greetings spoken by Muslims reflect the noble character of the Assalamu'alaikum (may peace be upon you). Islam is a progressive religion, against oppressors, capitalists, injustices, fighting for the rights of the oppressed little ones, glorifying women, and bringing about a harmonious and peaceful society within the framework of fraternity. Islam is a solutive religion, teaches the virtues of morality as opposed to bad morality, resolves nonviolent conflict, and contributes to giving spirit to build peace or conflict resolution, and also contributes in giving spirit to build peace or conflict resolution. The Qur'an’s solution to conflict is a suggestion for clarification, mediation, deliberation, forgiveness, reconciliation, good deeds, and justice. A holistic study of Islam will find the substance of Islam as a religion of  raḥmatan lil 'âlamḭn.
STRATEGI PENGEMBANGAN UMKM HALAL DI JAWA TENGAH DALAM MENGHADAPI PERSAINGAN GLOBAL
Authors: Pujiono Arif , Setyawati Ro'fah , Idris I
Published: September 2019

Abstrak Jawa Tengah sebagai bagian integral negara Indonesia memiliki potensi besar berupa Usaha Mikro Kecil dan Menengah (UMKM) halal dalam mendukung pembangunan. Sebagai wilayah dengan jumlah penduduk muslim yang besar dan memiliki jumlah UMKM terbanyak dan beraneka ragam, ternyata UMKM halal di Jawa Tengah belum mampu bersaing secara global. Penelitian ini memiliki tujuan utama untuk menetapkan strategi pengembangan UMKM halal di Jawa Tengah dalam menghadapi persaingan global. Metode yang digunakan adalah analisis statistik deskriptif melalui kuesioner terstruktur, indepth interview, focus group discussion (FGD) dengan tokoh kunci (key persons) dan analisis strenghts, weaknesses, oppotunities, dan threats (SWOT). Berdasarkan hasil analisis SWOT , maka strategi yang dapat dikembangkan untuk meningkatkan daya saing UMKM halal di Jawa Tengah adalah meningkatkan sertifikasi UMKM halal, meningkatkan kualifikasi SDM UMKM halal, menggunaan teknologi modern dan tepat guna untuk memenuhi standar produk UMKM halal, pemperkuat keterkaitan dengan industri (hilirisasi), melakukan diversifikasi produk UMKM halal, Meningkatkan peran lembaga keagamaan dan pendidikan untuk literasi produk UMKM halal kepada masyarakat muslim, meningkatkan peran fintech untuk pembiayaan dan sertifikasi produk UMKM halal beserta pemasarannya, membangun sinergi dengan institusi terkait untuk inovasi produk UMKM halal, meningkatkan branding produk UMKM halal melalui media teknologi dan informasi, memperkuat kajian fikih untuk menghasilkan produk UMKM halal Kata kunci: UMKM halal, Jawa Tengah, strategi pengembangan, dan SWOT
KEPUASAN PELANGGAN PO ROSALIA INDAH MENGGUNAKAN IMPORTANCE PERFORMANCE COMPETITOR ANALYSIS (IPCA)
Authors: Puspitasari Nia Budi , Pramono Susatyo Nugroho Widyo , Pertiwi Yoana Ellen
Published: September 2019

Persaingan yang ketat antara perusahaan dalam pelayanan bus antar kota antar provinsi membutuhkan perbaikan pelayanan kualitas untuk mempertahankan pelanggan. Adanya ketidakpuasan pelanggan terhadap fasilitas dan layanan yang diberikan oleh PO Rosalia Indah menjadi suatu permasalahan yang harus diperbaiki sehingga dengan menerapkan metode ini dapat meningkatkan kualitas pelayanan PO Rosalia Indah dan loyalitas penumpang. Penelitian ini bertujuan untuk menganalisa kepuasan pelanggan PO Rosalia Indah dengan mempertimbangkan keberadaan pesaingnya yaitu PO Pahala Kencana dan memberikan rekomendasi perbaikan terhadap atribut fasilitas yang menjadi prioritas perbaikan. Penelitian ini menggunakan metode Importance Performance Competitor Analysis (IPCA). Pengambilan data dilakukan terhadap dua kelompok responden yaitu responden PO Rosalia Indah dan responden PO Pahala Kencana. Penelitian ini mengukur tingkat pelayanan kualitas berdasarkan 3 dimensi yaitu kendaraan (15 butir pernyataan), sopir dan kru (8 butir pernyataan) dan manajemen (13 butir pernyataan). Berdasarkan hasil pengolahan data dengan IPCA didapatkan bahwa terdapat 21 butir pernyataan yang masuk dalam kuadran Urgent Action dan memerlukan perbaikan. Rekomendasi perbaikan dilakukan dengan metode Numerical Group Technique (NGT) yang berasal dari lima ahli yang mengerti dalam bidang transportasi bus.Abstract[The Customer Satisfaction of PO Rosalia Indah using Importance Performance Competitor Analysis (IPCA)] The intense competition between companies in intercity bus services between provinces requires the improvement of quality services to retain customers. The existence of customer dissatisfaction with the facilities and services provided by PO Rosalia Indah becomes a problem that must be improved so that by applying this method can improve the quality of service Rosalia Indah PO and passenger loyalty. This research aims to analyze customer satisfaction of PO Rosalia Indah by considering the existence of its competitor that is PO Pahala Kencana and give recommendation improvement to the facility attribute which become the priority of improving. This research uses Importance Performance Competitor Analysis (IPCA) method. The data were collected from two groups of respondents namely PO Rosalia Indah and respondent’s PO Pahala Kencana. This study measures the level of quality service based on 3 dimensions of the vehicle (15 points statement), driver and crew (8 points statement) and management (13 points statement). Based on the results of data processing with IPCA found that there are 21 items of statements that enter the Urgent Action quadrant and require improvement. The improvement recommendation was made by Numerical Group Technique (NGT) method which is derived from five experts who understand in the bus transportation field.Keywords: customer satisfaction; numerical group technique; IPCA
The Mechanism and Control Technology of Strong Strata Behavior in Extra-Thick Coal Seam Mining Influenced by Overlying Coal Pillar
Authors: Gao Rui , Kuang Tiejun , Lan Yiwen
Published: September 2019

This work aimed at revealing the mechanism of strong strata behavior in extra-thick coal seam mining which was influenced by an overlying coal pillar (OCP). To this end, the evolution characteristics of the stress and displacement in advance coal body of the working face were studied via numerical simulation. On this basis, the mechanism of strong strata behavior in working face affected by OCP was revealed. In situ monitoring also demonstrated that, as the working face mining near to the position of OCP, severe rib spalling and roadway deformation frequently appeared. The scheme of strengthening the hydraulic supports resistance and adding anchor cables was put forward to control the surrounding rocks in the stope. As a result, the maximum deformation of the roadway height was 0.66m and could completely meet the demands for safe mining. The study on the mechanism of strong strata behavior in working face and the strengthen supporting scheme would provide a theoretical basis for similar mining conditions, thus ensure safe and efficiency coal seam mining.
Numerical Simulation of Flow Distribution in the Reactor Used for CFRPs Degradation under Supercritical Condition
Authors: Cheng Huanbo , Liu Weihao , Huang Haihong , Liu Zhifeng
Published: September 2019

Supercritical fluids with excellent decomposition and mass transfer capabilities can degrade the resin matrix of carbon fiber reinforced polymer (CFRPs) to recycle high-performance carbon fibers. The degradation rate of CFRPs was influenced by the velocity and temperature distributions of supercritical fluids in the reactor with mechanical stirring. The flow field model in the reactor was established during the degradation of CFRPs by supercritical ethanol. The velocity and temperature distributions in both the axial and radial directions were simulated when the stirrer was installed in the reactor at different heights. The simulation indicated that the flow distribution was uneven in the reactor and the position with optimum flow distribution for placing CFRPs was 45 %–70 % of the installation distance between underside of the impeller and the base of the reactor. The experiment shows mechanical stirring can significantly promote CFRPs degradation. When the installing height of the stirrer is 110 mm, the degradation rate of the epoxy resin is 10 % higher than that without stirring. The degradation rate of epoxy resin was also affected by the placement position of CFRPs in the reactor, and could be improved by approximately 14 % higher than that without mechanical stirring when the CFRPs were placed in the position with optimum flow distribution.
3D CFD Simulation of Gas Hold-up and Mass Transfer in a Modified Airlift Reactor with Net Draft Tube
Authors: Nalband Mehran , Jalilnejad Elham
Published: September 2019

This paper documents CFD simulations of the gas hold-up (ɛg) and volumetric mass transfer coefficient (KLa) for three kinds of airlift reactors (ALRs) namely, conventional ALR, ALR with net draft tube (ALR-ndt), and packed-bed ALR with net draft tube (PBALR-ndt). The 3D two-fluid Eulerian-Eulerian model was adopted to predict the influence of superficial gas velocity on ɛgand KLa. The simulation results were consistent with the trends described previously in the experimental work regarding ɛgand KLa values and a good agreement was obtained (absolute error less than 20 %). Based on the simulation results, axial flow is the dominant flow in the conventional ALR while in ALR-ndt and PBALR-ndt radial flow streamlines are appeared in the reactors due to the presence of concentric net draft tube which improves their performance. The effective role of the net draft tube is proven since consequence of generation of small bubbles by passing through net draft tube is the entrainment of a larger percentage of gas bubbles from the riser into the downcomer which results in improvement of gas holdup and the KLa values. An exponential correlation is used for relating gas hold-up and mass transfer coefficient. Higher power obtained for ALR-ndt and PBALR-ndt (n ≈ 1.22) compared to ALR (n = 0.95) was indicative of high sensitivity of KLa value to gas hold-up in these reactors due to presence of the concentric net draft tube. The CFD modeling is considered to be an invaluable tool allowing us to analyze and visualize the impact of fluidic forces on hydrodynamic properties and consequently, reactor performance.
Transient Simulation of Natural Gas Network by Hybrid Taguchi Binary Genetic Algorithm
Authors: Moetamedzadeh Hamid Reza , Khanmirza Esmaeel , Madoliat Reza
Published: September 2019

The analysis of gas transportation networks is the backbone for further processes such as optimization and control. The static analysis is based on algebraic equations which are straightforward and easy to solve, but may result in solutions far from the optimum due to the dynamic nature of the network. Hence, the transient analysis is inevitable. It is based on a set of equations containing partial differential equations (PDEs) for each pipeleg (Navier–Stokes equations), algebraic equations of compressors, the initial conditions and the boundary values. Since the governing equations of each pipeleg are PDEs, the internal boundary values of the network should be considered according to the topography of the pipelegs in the network, which makes the traditional transient analysis complicated and time consuming. In this paper, a straightforward method based on metaheuristic algorithms is proposed for the transient analysis. Using the proposed technique, each pipeleg is analyzed separately which speeds up the analysis. The source flow rates are considered as the optimization variables and based on them, the demand pressures are calculated. The sum of the absolute differences between the real demand pressures (known as the boundary values) and the calculated ones is the error of the proposed modeling. To minimize the error, a powerful metaheuristic algorithm called Hybrid Taguchi Binary Genetic Algorithm is utilized. Numerical results confirm the efficiency and accuracy of the proposed method that leads to near-zero error.
Crystal structure of (E)-3-chloro-2-(((4-nitrophenyl)imino)methyl)phenol, C13H9ClN2O3
Authors: Song Wei , Yang Yanju , Li Jin
Published: September 2019

C13H9ClN2O3, orthorhombic, P212121 (no. 19), a = 7.401(3) Å, b = 12.005(5) Å, c = 13.808(5) Å, V = 1226.8(8) Å3, Z = 4, R
gt(F) = 0.0673, wR
ref(F
2) = 0.1473, T = 293(2) K.
Targetsalden und die Vollendung der Währungsunion
Authors: Spahn Peter
Published: September 2019

Targetsalden zeigen Zahlungsbilanzungleichgewichte an, stellen jedoch keine wertmäßige Kompensation für die damit verbundenen Wohlfahrtsübertragungen dar. Sie lassen sich als Beitrag zur Milderung der Anpassungskosten makroökonomischer Krisen legitimieren, verletzen jedoch grundsätzlich währungspolitische Normen transnationaler Wirtschaftsbeziehungen. Entgegen der Meinung Hellwigs gilt dies auch für die Europäische Währungsunion, die unter anderem aufgrund des Fortbestands nationaler Notenbanken nicht mit der alten DM-Währungsunion vergleichbar ist. Nur in einer politischen Union sind Targetsalden unbedeutend.
Pitfalls and Remedies for Cross Validation with Multi-trait Genomic Prediction Methods
Authors: Runcie Daniel , Cheng Hao
Published: September 2019

Incorporating measurements on correlated traits into genomic prediction models can increase prediction accuracy and selection gain. However, multi-trait genomic prediction models are complex and prone to overfitting which may result in a loss of prediction accuracy relative to single-trait genomic prediction. Cross-validation is considered the gold standard method for selecting and tuning models for genomic prediction in both plant and animal breeding. When used appropriately, cross-validation gives an accurate estimate of the prediction accuracy of a genomic prediction model, and can effectively choose among disparate models based on their expected performance in real data. However, we show that a naive cross-validation strategy applied to the multi-trait prediction problem can be severely biased and lead to sub-optimal choices between single and multi-trait models when secondary traits are used to aid in the prediction of focal traits and these secondary traits are measured on the individuals to be tested. We use simulations to demonstrate the extent of the problem and propose three partial solutions: 1) a parametric solution from selection index theory, 2) a semi-parametric method for correcting the cross-validation estimates of prediction accuracy, and 3) a fully non-parametric method which we call CV2*: validating model predictions against focal trait measurements from genetically related individuals. The current excitement over high-throughput phenotyping suggests that more comprehensive phenotype measurements will be useful for accelerating breeding programs. Using an appropriate cross-validation strategy should more reliably determine if and when combining information across multiple traits is useful.
The management of hiatal hernia: an update on diagnosis and treatment
Authors: Sfara Alice , Dumitrașcu Dan L
Published: September 2019

Background and aim. Hiatal hernia (HH) occurs quite frequently in the general population and is characterized by a wide range of non-specific symptoms, most of them related to gastroesophageal reflux disease. Treatment can be challenging at times, depending on the existence of complications. The most recent guideline regarding the management of hiatal hernia was released by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) in the year 2013. This review aims to present  the most recent updates on the diagnosis and management of hiatal hernia for clinical practitioners.

Methods. The PubMed database was screened for publications using the terms: “hiatal hernia”, “paraesophageal hernia”, “management”, “treatment”, “hiatal repair”. A literature review of contemporary and latest studies was completed. The studies that we looked into include prospective, randomized trials, systematic reviews, clinical reviews and original articles. The information was compiled in narrative review format.

Results. This narrative review presents new data on the diagnosis and management of hiatal hernia. While the diagnostic pathway has remained virtually unchanged, new data have come to light regarding the surgical treatment of hiatal hernia. We present the imaging methods used for its diagnosis, as well as the medical and surgical treatment currently available.

Conclusions. In the last five years, there has been vast research in the field of hiatal hernia management, especially regarding the surgical treatment. However, unanswered questions still remain and solid updates on the guidelines have yet to be formulated. To address this, more randomized studies need to be done on subsets of patients, stratified by age, gender, symptoms and comorbidities.
Improving Emergency Department Management of Diabetic Ketoacidosis in Children
Authors: Baumer-Mouradian Shannon H. , Gray Matthew P. , Wolfgram Peter M. , Kopetsky Matthew , Chang Franklin , Brousseau David C. , Frenkel Mogen M. , Ferguson Catherine C.
Published: September 2019

BACKGROUND:

Diagnostic delays in the pediatric emergency department (ED) can lead to unnecessary interventions and prolonged ED length of stay (LOS), especially in patients with diabetes mellitus evaluated for diabetic ketoacidosis (DKA). At our institution, baseline DKA determination time (arrival to diagnosis) was 86 minutes, and 61% of patients did not meet DKA criteria. Subsequently, intravenous (IV) placement occurred in 85% of patients without DKA. We aimed to use point-of-care (POC) testing to reduce DKA determination time from 86 to 30 minutes and to reduce IV placements in patients without DKA from 85% to 20% over 18 months.

METHODS:

Four key interventions (POC tests, order panels, provider guidelines, and nursing guidelines) were tested by using plan-do-study-act cycles. DKA determination time was our primary outcome, and secondary outcomes included the percentage of patients receiving IV placement and ED LOS. Process measures included the rate of use of POC testing and order panels. All measures were analyzed on statistical process control charts.

RESULTS:

Between January 2015 and July 2018, 783 patients with diabetes mellitus were evaluated for DKA. After all 4 interventions, DKA determination time decreased from 86 to 26 minutes (P < .001). In patients without DKA, IV placement decreased from 85% to 36% (P < .001). ED LOS decreased from 206 to 186 minutes (P = .009) in patients discharged from the hospital after DKA evaluation. POC testing and order panel use increased from 0% to 98% and 90%, respectively.

CONCLUSIONS:

Using quality-improvement methodology, we achieved a meaningful reduction in DKA determination time, the percentage of IV placements, and ED LOS.
Мечта как проекция будущего
Authors: Masyuk O. P.
Published: September 2019

В статье рассматривается мечта как проекция желаемого существования в неопределенной перспективе, а также необходимость ее использования в процессе саморазвития. Мечта определяется как совокупность чувств, разума и воли, которая способна сформировать субъективно идеальную картину потенциального бытия. Акцент делается на значении желаемого будущего, его направленности, индивидуальной и коллективной полезности. Приоритетная активность мечтателей описывается как основа для кардинальных социальных изменений. В статье дается классификация мечты по принадлежности, осмысленности, воздействию на жизнь человека. Особое внимание уделяется художественному воплощению мечтаний и их влиянию на социокультурное развитие. Механизм сопоставления человеческих достижений рассматривается как стимул для реализации мечты. Мечта представлена как идеальная проекция существования в будущем, которая включает совокупность человеческих желаний и идеалов общества. Способность к мечтаниям описывается как фундамент для проектирования оптимальной перспективы сосуществования в социальном пространстве. Несбыточность мечты ассоциируется с неточностью в выборе желаемого объекта и методов для его получения. Результаты исследования могут применяться в усовершенствовании преподавания таких дисцип­лин, как «Философия», «Психология», «Менеджмент», «Политология». Осмысление мечты имеет ценность для маркетинговых исследований и управления социальными процессами.
Власть как источник конституирования неравенства гендерных идентичностей
Authors: Skiba E. K.
Published: September 2019

Социальная стабильность является одной из основных конечных целей любого государства. Не отвергая различие и разнообразие общество должно стремиться преодолеть социальную дихотомию, которая результатируется в неравенство. Цель статьи заключается в изучении сложного механизма повсеместного проникновения гендерного неравенства, чтобы найти пути возможного решения этой проблемы. Среди методов исследования можно выделить герменевтический метод, который позволил выявить и проанализировать не только явные признаки проблемы, но и те, которые проявляются в контексте существования проблемы. Использован также диалектический метод, позволивший рассмотреть проблему в ее развитии. Анализ и синтез позволили  установить взаимодействие и связи разных элементов категорий «неравенства» и «различия», что позволило познать  категорию «власть»  как единое целое и установить, что социальные институты постоянно воспроизводят на всех уровнях гендерное неравенство.