bluuebunny/crossref_metadata_2025 huggingface dataset:
Variation in health and well-being parameters: cross-country and temporal aspects
Authors: Zhuravleva Irina V.
Published: August 2024

BACKGROUND: The coronavirus epidemic has stimulated large-scale structural and socio-economic changes throughout the world and led to increased attention to the problem of health in general. But has the epidemic affected the change in the attitude of people of different ages to their health, the perception of various parameters of subjective well-being? The article presents a comparative analysis of a number of assessments (about the level of happiness, satisfaction with income, healthcare, safety, communication, life, attitude towards people, etc.) of respondents from Europe and Central Asia for the period 2006–2021.
AIM: The goal is to assess changes that have occurred over a 15-year time interval in relation to health and social determinants of well-being, to determine possible directions for changing the current situation.
METHODS: To achieve this goal, the results of the tenth wave of the international comparative European Social Survey, conducted in 2021 (32 countries), were used in comparison with data from the third wave, conducted in 2006 (25 countries). The impact of the pandemic on the health of children and adolescents aged 11–15 years was based on materials from the international Health Behavior in School-Aged Children 2021–2022 in 44 countries in Europe and Central Asia.
RESULTS: Despite the difficulties, dictated by the coronavirus, over the period 2006–2021 in most European countries stability in the perception of the world of work and the healthcare institution has been maintained, the psychological situation related to the safety of living has improved, and life satisfaction has increased. According to most of the parameters considered, Russians are outsiders among European countries; however, Russians’ responses to 7 indicators of health and well-being (out of 12) show positive changes. The results of studies of the health of children and adolescents during the pandemic and post-pandemic periods indicate significant negative consequences, mainly related to mental health.
CONCLUSION: It is necessary to increase the attention of Russian government bodies to the health and well-being of Russians, first of all, to children and adolescents.
Educational psychology for the effective management of medical-psycho-pedagogical centres: a correlation study
Authors: Kasmi A. , Touri B.
Published: August 2024

Introduction. Educational psychology focuses on the psychological aspects of learning and teaching to optimise education by understanding how individuals develop skills and acquire knowledge in an educational context. Aim. The study aims to understand how educational psychology can help the effective management of medical-psycho-pedagogical centres (CMPPs) and to identify the links and synergies between the principles of educational psychology and the practice of managerial aspects within such centres. Research methodology and methods. The authors used a quantitative methodology based on a non-experimental correlational study. The sample included 100 CMPPs in the Ile-de-France region. The directors of these centres were invited to complete the questionnaire hosted on the Google Forms platform. The results were processed using IBM SPSS 29. Results and scientific novelty. Of the six relationships studied, the results revealed four significant relationships between the “psychology of education” variable and managerial aspects, namely team structure and management, quality and safety of care, patient data management and interprofessional cooperation. The above-mentioned relationships represent 80% of the significant relationships between educational psychology and managerial aspects. The scientific novelty of the research lies in examining the relationship between educational psychology and managerial dimensions, providing a clear vision of the essential role of educational psychology in the management of CMPPs. Practical significance. These results underline the importance for each country of integrating the principles of educational psychology into the development of their CMPPs. This is particularly crucial for Morocco, in alignment with the 2015–2030 strategic vision to establish these centres.
Disease modifiers and novel markers in hepatitis B virus-related hepatocellular carcinoma
Authors: Mak Lung-Yi
Published: August 2024

Chronic hepatitis B (CHB) infection is responsible for 40% of the global burden of hepatocellular carcinoma (HCC) with a high case fatality rate. The risk of HCC differs among CHB subjects owing to differences in host and viral factors. Modifiable risk factors include viral load, use of antiviral therapy, co-infection with other hepatotropic viruses, concomitant metabolic dysfunctionassociated steatotic liver disease or diabetes mellitus, environmental exposure, and medication use. Detecting HCC at early stage improves survival, and current practice recommends HCC surveillance among individuals with cirrhosis, family history of HCC, or above an age cut-off. Ultrasonography with or without serum alpha feto-protein (AFP) every 6 months is widely accepted strategy for HCC surveillance. Novel tumor-specific markers, when combined with AFP, improve diagnostic accuracy than AFP alone to detect HCC at an early stage. To predict the risk of HCC, a number of clinical risk scores have been developed but none of them are clinically implemented nor endorsed by clinical practice guidelines. Biomarkers that reflect viral transcriptional activity and degree of liver fibrosis can potentially stratify the risk of HCC, especially among subjects who are already on antiviral therapy. Ongoing exploration of these novel biomarkers is required to confirm their performance characteristics, replicability and practicability.
Retraumatization in Undergraduate Medical Education: Evaluating the Prevalence and Support Resources Available to Students
Authors: Makhecha Keith , Doster Dominique L. , Standfest Makayla , Ritter E. Matthew , Stefanidis Dimitrios
Published: August 2024

Background:
Retraumatization is the conscious or unconscious reminder of past trauma that results in a re-experiencing of the initial traumatic event. This phenomenon has been well-studied in primary and secondary education and has been shown to negatively impact the learning environment. Retraumatization in the context of undergraduate medical education has yet to be evaluated. Therefore, we sought to explore the prevalence of retraumatization in medical students, identify specific areas of UME that are retraumatizing, and evaluate effectiveness of psychological support available to students.
Methods:
A survey was created by a multidisciplinary team of health professions educators, revised through an iterative process, and distributed to all medical students at a single, large, academic institution. Respondents who endorsed prior trauma exposure met inclusion criteria for completing the survey. Data was analyzed using Microsoft Excel.
Results:
Of the school’s 1400 students, 85 responses were recorded for a response rate of 6.07%; this consisted of 20 males (23.5%), 46 females (54.1%), and 19 nonbinary (22.4%) students. 32 (37.6%) students reported no prior trauma and were excluded from survey completion. Of the 53 (62.4%) students completing the survey, retraumatization was experienced by 32 students (60.4%), which represents a prevalence of 37.6% among all medical students surveyed. 50% of females (n=23), 10% of males (n=2), and 36.8% of nonbinary (n=7) students reported retraumatization. Clinical rotations were identified as a retraumatizing setting by 59.3% (n=19) of students. Despite the availability of support services, 11 students (20.8%) reported being unaware of them when experiencing retraumatization. When asked about utilization of services, the majority of those who had experienced retraumatization did not utilize them (65.6%, n=21).
Conclusion:
Retraumatization is occurring in undergraduate medical education, particularly in the clinical years.  Medical schools should attempt to enhance the ease of utilization of support resources to improve the learning environment for students.
Prevalence, Clinical Features, Treatment, and Outcomes in Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries
Authors: Hoang T. H. , Maiskov V. V. , Merai I. A. , Kobalava Zh. D.
Published: August 2024

Aim. To study clinical and demographic characteristics, treatment options, and clinical outcomes in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) compared with patients with myocardial infarction with obstructive coronary arteries (MIOCA).Material and methods. This single-center prospective observational study included 712 successive patients diagnosed with acute myocardial infarction (MI), who routinely underwent direct coronary angiography. Based on the presence of stenosing coronary atherosclerosis, the patients were divided into two groups: MIOCA (coronary stenosis ≥50%) and MINOCA (coronary stenosis <50% without other, alternative causes). Clinical outcomes included in-hospital and long-term overall mortality, and cardiovascular rehospitalization. The median follow-up was 1.5 years.Results. MINOCA was diagnosed in 73 (10.3%) patients, 37 (50%) of whom were women. The median age of patients with MINOCA was 61 years and in the MIOCA group 65 years. No significant differences in cardiovascular risk factors were found between patients with MINOCA and MIOCA. In 53.4% of cases, the cause of MINOCA was a discrepancy between the myocardial oxygen demand and supply, and in 35.6% of cases, the cause was hypertensive crisis and pulmonary edema. The factors associated with MINOCA included an age ≤58 years, female gender, absence of the ST-segment elevation, absence of areas of impaired local contractility, and presence of aortic stenosis and bronchopulmonary infection. Patients with MINOCA were less likely to be prescribed acetylsalicylic acid, P2Y12 inhibitors, dual antiplatelet therapy, beta-blockers, and statins (p<0.05). Data on long-term outcomes were available for 87.5% of patients (n=623). The prognosis of patients with MIOCA was comparable for in-hospital mortality (1.5% vs. 6.2%; p=0.161) and long-term overall mortality (6.1% vs. 14.7%; p=0.059). Cardiovascular rehospitalizations were more frequent in the MINOCA group (33.3% vs. 21.5%; p=0.042).Conclusion. The prevalence of MINOCA in our study was 10.3% among all patients with acute MI. MINOCA patients had comparable generally recognized cardiovascular risk factors with MIOCA patients. MINOCA patients had a comparable prognosis for in-hospital and long-term mortality and more often required cardiovascular rehospitalization.
Reducing Cybersecurity Risks at the Organization’s Endpoints: Cybersecurity Best Practices
Authors:   Israel National Cyber Directorate
Published: August 2024

This publication presents a series of measures that allow for the protection of physical devices, such as desktop computers and mobile devices, that connect to an organizations network system, commonly referred to as “endpoints” of the network, by establishing security protocols based on physical security and access prevention, permission management, information protection, and software implementation. The document refers to a wide range of endpoints, irrespective of their operating system, terminal type, or where they connect from within the organization, with readers being able to implement the recommendations regardless of whether they deal with internal fixed or mobile stations or when connecting other devices that are not the property of the organization to the intranet. This publication is part of the "Cybersecurity Best Practices" collection, a compendium of practices, methodologies, and recommendations in cybersecurity oriented to organizations, developed by the Israel National Cyber Directorate (INCD), and adapted in this series by the Inter-American Development Bank (IDB), with the objective of facilitating access to this body of knowledge throughout the Latin American and Caribbean region.
Efectos de la pandemia COVID-19 en el crecimiento y la rentabilidad de las empresas manufactureras colombianas
Authors: Melgarejo Molina Zuray Andrea , Serna Hernández Juan Camilo
Published: August 2024

El objetivo de este trabajo es analizar el impacto del efecto de la pandemia de la COVID-19 en el comportamiento del crecimiento y la rentabilidad empresarial en Colombia. Para lograrlo, se empleó un método de análisis de datos financieros provenientes de 850 empresas colombianas, utilizando un enfoque de datos panel y aplicando el modelo estadístico de efectos fijos y primeras diferencias. Los resultados obtenidos confirmaron la relación existente entre la rentabilidad y el crecimiento empresarial. Además, no se encontraron indicios de una codependencia entre estas variables, ya que tal relación depende de los aspectos particulares de cada contexto. Se observaron impactos tanto positivos como negativos provocados por la COVID-19 en las variables analizadas. Las discusiones posteriores al análisis coinciden con otros estudios al destacar la correspondencia entre la rentabilidad y el crecimiento empresarial. Asimismo, se señala que si bien la mayoría de los impactos de esta pandemia presentan similitudes, varían según el contexto específico de cada empresa. La magnitud de ellos se relaciona con la eficiencia de las respuestas ofrecidas por los gobiernos como por las propias empresas. Estos factores influyen en la interpretación de los resultados y sus implicaciones. En conclusión, este estudio resalta la importancia de profundizar en modelos que permitan cuantificar de manera precisa los impactos de la enfermedad en la rentabilidad y el crecimiento empresarial. Además, se subraya la necesidad de continuar estudiando las tendencias en estas variables, con el objetivo de comprender mejor los efectos a largo plazo en el entorno empresarial colombiano.
Is The Answer in The East? Trade Agreements with East Asia as an Opportunity for Latin American Exports: The Case of Chile
Authors: Cañizares Arévalo Jorge de Jesús , Cárdenas García Maribel , Durán Chinchilla Claudia Marcela
Published: August 2024

Trade Agreements (TAs) are instruments crafted and implemented by policymakers with the aim of enhancing trade between countries or regions/economic blocs. In this study, a gravity model was utilized to estimate the effects within a panel of 165 countries, examining Chilean exports across total, agricultural, and manufacturing sectors. The findings largely align with theoretical expectations: the presence of FTAs tends to bolster Chile’s exports to partner nations, with a more pronounced effect observed for FTAs. Notably, FTAs with South Korea, China, and Japan have facilitated trade growth exceeding the average increase, both across total exports and within the manufacturing sector. Additionally, the FTA with South Korea has shown significant growth in agricultural exports compared to exports to other countries.
Conflitos Hídricos pelo Uso da Água
Authors: Soares Jane Arimércia Siqueira , Moreira Barbosa Erivaldo
Published: August 2024

A água é um dos recursos naturais mais abundantes no planeta e essencial a manutenção da vida. No entanto, nas últimas décadas, os conflitos hídricos têm se destacado em decorrência do aumento da demanda pelo uso da água, tendo origem em fatores de escassez que engloba aspectos de qualidade e quantidade e em decorrência da inexistência ou ineficácia de um processo adequado de gerenciamento. Sendo assim, o presente estudo buscou identificar os conflitos pelo uso da água, como estes se apresentam. Quanto a metodologia, utilizou-se do método dedutivo e da pesquisa bibliográfica a partir de trabalhos já elaborados. Por fim, conclui-se que os conflitos pelo uso da água podem se manifestar das mais variádas formas, desde de um indivíduo até grupos maiores, como continentes, países, Estados Municípios, que estes podem se apresentar a partir de um problema de escassez decorrente de fatores climáticos, ou mesmo pela falta de gerenciamento do mesmo, também constatou-se que estes têm persistido ao longo do tempo e que são necessárias mudanças na forma de gerir a água, bem como, Políticas Públicas que possibilitem uma distribuição consciente entre os usuários e promova uma distribuição social igualitária conforme as necessidades.
Antibiotics Utilization Pattern in a Children’s Medical Center in North of Iran
Authors: Shahrokhi Maryam , Hashemian Houman , Dadras Mehrdad , Bouzari Saba , Shafaei-Bajestani Negar
Published: August 2024

Background: The development of a system for rational use of antimicrobials seems mandatory. Furthermore, since hospitals do not share the same bacterial flora and have different patterns of antibiotic therapy the purpose of the present study is to perform a Drug Utilization Evaluation (DUE) on the pattern of antibiotic administration in patients hospitalized in 17 Shahrivar Pediatric Hospital, RASHT, Iran.
Methods: In this descriptive cross-sectional study that was conducted in a one-year period (2021-2022), 560 patients were randomly selected and their medication data were collected based on the gender and age as well as the type, dose, duration of antibiotic therapy and the results of bacterial cultures and also susceptibility of the infectious microorganisms.
Results: The average age of patients was 53.56 months with 46.9% of them being less than 24 months old. The highest rate of antibiotics administration belonged to the infectious diseases ward (30%) and 33% of antibiotics were prescribed by pediatric infectious diseases specialists. The result of most of the cultures was reported as negative (98.38%), the most prevalent microorganism was Escherichia Coli from urine cultures (2.38%) and Staphylococcus Aureus from sputum cultures (14.28%). The highest prescribed antibiotics were ceftriaxone (51.2%) and vancomycin (45.6%). It was determined the antibiotic stipend was 15.6% of the whole budget for purchasing medicine.
Conclusions: It is necessary to develop a guideline regarding the prescription of antibiotics in children's departments, which reduces empiric treatment and the requirement to adjust the drug after a negative culture.
Impact of Statin or Angiotensin Converting Enzyme Inhibitor/Angiotensin Receptor Blocker on In-Hospital Mortality of COVID-19 Patients
Authors: Jelodar Mohsen Gholinataj , Mirzaei Samaneh , Maghsoudi Majid Haji
Published: August 2024

Background: It is important to determine the risk factors that contribute to the mortality of a disease and take measures to prevent or alleviate it. In the case of COVID-19, old age, male gender, and comorbidities such as diabetes (DM) and hypertension (HTN) have been identified as potential risk factors. However, there is conflicting information on the effects of statins and ACEI/ARB in COVID-19 patients admitted to the ICU, particularly those with diabetes or hypertension. This study aims to investigate the effects of these drugs on the in-hospital prognosis of ICU COVID-19 patients, with a focus on patients with DM or HTN.
Methods: During 18 months, we conducted a descriptive-analytical observational analysis on 391 patients who were admitted to the ICU. The study focused on COVID-19 patients and aimed to identify mortality risk factors by assessing their demographic, clinical, pharmaceutical, laboratory, and imaging data. We statistically analyzed the data to achieve this goal.
Results: Out of 391 patients, 83 received statins and 89 received ACEI/ARBs. The research has revealed that the use of ACEI/ARBs in COVID-19 patients admitted to the ICU may increase the risk of endotracheal intubation (P<0.0001) and mortality (P<0.0001). Additionally, patients treated with these drugs are more likely to experience secondary bacterial infections (P=0.007) and venous thromboembolism events (P=0.015). The results of a recent study analyzing diabetic and hypertensive patients hospitalized in ICU showed that there is no significant difference in clinical outcomes between COVID-19 patients who used ACEI/ARB and those who did not. Our study has found that the use of statins in diabetic patients is linked to a reduction in mortality rate (0.008) and secondary bacterial infections (P=0.035) of COVID-19 patients admitted to the ICU. In multivariate logistic regression, the use of statin or ACE/ARB was not identified as the mortality prediction factor.
Conclusion: Statins can help reduce mortality rates among COVID-19 patients, especially in diabetic patients, hospitalized in the ICU. So, they should be used to manage cardiovascular risk factors and lower the mortality risk. Statins and ACEI/ARB drugs were not predictors of mortality and did not decrease survival rates during ICU hospitalization.
Epidemiologic Analysis of Drug and Poison Information Center (DPIC) Inquiries: A Four-Year Cross-Sectional Study in Hamadan, Iran (2019-2023)
Authors: Emami Shahaboddin , Ghalandari Nasibeh
Published: August 2024

Background: Drug and Poison Information Centers (DPIC) play a pivotal role in pharmacovigilance, public education, and preventing adverse drug reactions, medication errors, and poisoning incidents.
Methods: This study presents an epidemiologic analysis of inquiries received by the DPIC at Hamadan University of Medical Sciences in Iran over four years (2019-2023). A descriptive cross-sectional analysis of recorded phone calls to the DPIC at Hamadan University of Medical Sciences from October 2019 to November 2023. The demographic distribution of inquirers, types of inquiries, and sources used to answer questions were considered in the analysis.
Results: The study reports a total of 3904 recorded calls over the four-year period, with an average of 78.08 calls per month. The majority of callers were female (61%). The top three questions focused on coronavirus, side effects, and drug-drug reactions. Psychiatric agents, gastrointestinal agents, and antibiotics were the top three drug families inquired about. The data were collected from various references, with UptoDate® being the most frequently used (43.3%).
Conclusion: This study provides a comprehensive epidemiologic analysis of inquiries received by the DPIC at Hamadan University of Medical Sciences. The findings underscore the importance of DPICs in providing evidence-based information, contributing to pharmacovigilance, and enhancing patient safety.
Analyzing the Phytochemistry and Bioactive Compounds of Abutilon indicum for antidiabetic activity Using TLC, HPTLC, GC-MS in Aqueous, Ethanol, and Chloroform Solvents for Pharmacognosy Determinations
Authors:   Department of Pharmacognosy, Prof. Ravindra Nikam College of Pharmacy Gondur, KBC NMU Jalgaon, Dhule, Maharashtra, India, Jadhav N R , Patil R B
Published: August 2024

In this systematic investigation of Abutilon indicum extracts for antidiabetic activity, using TLC and HPTLC were employed to analyze bioactive compounds. The ethanolic extract (EA) exhibited specific RF values: 0.16 for catechin, 0.57 for gallic acid, and 0.70 for quercetin, with Abutilon indicum (EA) containing the highest percentages—48.87% catechin, 27.45% gallic acid, and 7.25% quercetin. The robustly developed and validated HPTLC process, applied to ethanolic extracts, demonstrated clear bands and sharp peaks, ensuring precise separation of bioactive compounds. Similar methodologies were employed for chloroform extract (CA) and aqueous extract (AA), revealing RF values of 0.10, 0.36, and 0.54 for CA, and 0.087, 0.36, and 0.53 for AA, corresponding to catechin, gallic acid, and quercetin, respectively. Fingerprinting analysis confirmed the simultaneous presence of these compounds, highlighting the method's utility for quality control. Statistical analysis supported the reliability and cost-effective suitability of HPTLC for quantitative analysis in assessing herbal material and formulations. GC-MS exploration of Abutilon indicum extracts revealed over 20 compounds in each, including flavonoids, alkaloids, and terpenoids in the ethanolic extract, and phytosterols, alkaloids, and terpenoids in the chloroform extract. The aqueous extract displayed a diverse phytochemical composition, affirming medicinal potential. These results collectively endorse Abutilon indicum's versatility and therapeutic potential in herbal medicine and pharmaceutical formulations. Keywords Pharmacognosy, Bioactive Compounds, Analytical Study, Abutilon indicum etc
APLICAÇÃO DE MÉTODOS MATEMÁTICOS PARA ANALISAR A AÇÃO RADIOPROTETORA DO Ginkgo biloba A NÍVEL CEREBRAL
Authors: De Andrade Tenorio Cavalcanti Camilla , Álvaro de Alcântara Aguiar Leandro , Parísio Barbosa de Oliveira3 Alexandre , Sérgio de Oliveira Filho Jonas , Cardoso Campos de Assunção Beatriz , Marques dos Santos Yasmin , Ribeiro Leite Celestino Vanessa , Maria Serafim da Silva Lopes Isvânia , De Albuquerque Nogueira Romildo
Published: August 2024

Introdução: O efeito protetivo do Ginkgo biloba (Gb), um antioxidante natural, contra a toxicidade induzida por agentes químicos e físicos tem sido alvo de estudos. Objetivo: Propor métodos quantitativos associados a técnicas histológicas para analisar a eficácia do Gb como radioprotetor cerebral. Método: Utilizaram-se 35 ratos, agrupados em: grupo 1: controle; grupo 2: exposto a radiação ionizante (RI); grupo 3: tratado com o Gb; grupo 4: exposto a RI e posteriormente tratado com o Gb; grupo 5: tratado com o Gb e posteriormente exposto a RI. Os registros obtidos pelo eletrocorticograma, foram avaliados através da Transformada de Fourier, Entropia Aproximada e Complexidade de Lempel-Ziv. Por fim, foi realizado a coleta e análise do hipocampo por meio de técnicas histologias. Resultados: A análise dos experimentos mostra que a RI interfere na atividade elétrica cortical, aumentando a frequência das ondas delta e beta e diminuindo teta e alfa. Já os grupos 4 e 5 se assemelharam ao 1, demostrando uma capacidade radioprotetora. Em relação a histologia, foi identificada apoptose no grupo 2 na região CA1 e Giro Denteado do hipocampo. Conclusão: Com base nesses dados, conclui-se que o efeito protetor do extrato do Gb pode atuar como uma terapia adjunta para redução da toxicidade induzida pela RI.
COVID-19: Dados epidemiológicos e medidas de saúde pública em Pernambuco
Authors: Alves da Costa Victor , Crispim Joelson , Cristiny Pereira Michelly , Jesus Barreto de Melo Rêgo Moacyr , Galdino da Rocha Pitta Maira , Melgarejo da Rosa Michelle
Published: August 2024

A pandemia de COVID-19 afetou o modo de vida de grande parte da população mundial. Medidas de saúde pública têm contribuído para reduzir a transmissão do vírus SARS-CoV-2. Até o momento, mais de cinco milhões de mortes estão relacionadas ao desenvolvimento da doença ao redor do mundo. O presente estudo discorre sobre as os dados epidemiológicos revelados sobre número de casos, mortes, medidas em saúde pública adotadas e como elas se comunicaram com o desenvolvimento da doença.  Os dados foram coletados de bancos de dados de domínio público, como o DATASUS e dados da secretaria estadual de saúde de Pernambuco até mês de outubro de 2022. Em linhas gerais foi possível perceber que medidas em saúde pública contribuíram com o declínio do número de casos e mortes induzidos pela infecção do vírus SARS-CoV2. A resposta do poder público na utilização de lockdowns e rastreamento de novos casos melhorou ao longo da pandemia. Além disso, vacinação da população evitou muitas mortes durante a onda de infecções causadas pela variante Ômicron.
Antioxidant, Antiproliferative and Antibacterial Activity of Phoradendron californicum Extracts; a Parasitic Plant from Northwestern Mexico
Authors: Mendez-Pfeiffer Pablo , Ballesteros-Monrreal Manuel G , Leyva Mario , Ortega-García Jes´ús , Montaño-Leyva Beatriz , Valencia Rivera Dora Edith , Aguilar-Martinez Milagros
Published: August 2024

Phoradendron californicum is a plant native of northwestern Mexico that has been used as a therapeutic alternative. In the present study, methanolic and chloroformic extracts of P. californicum were prepared and evaluated for their antioxidant activities, phenolic and flavonoid content, as well as their antiproliferative activity in cancer cells and antibacterial activity. The methanolic extract presented higher antioxidant activity (IC50: 47.62 ± 2.90 μg/mL) and higher total phenol content (186.45 ± 4.58 μg/mL) compared to the chloroformic extract (IC50: ˃400 ug/mL and 13.54 ± 1.57 μg/mL, respectively), both extracts presented similar content of total flavonoids (19.92 ± 1.84 and 25.55 ± 0.73 μg/mL, respectively). On the other hand, the chloroformic extract presented higher antiproliferative activity in the cell lines evaluated (HeLa, PC3 and L929) compared to the methanolic extract, meanwhile, in the antibacterial activity the chloroformic extract presented higher activity against Escherichia coli and Listeria monocytogenes, while the methanolic extract was more active against Salmonella enterica. The clear difference in the biological activities of both extracts may be due to differences in the chemical composition of each due to the extraction method used. P. californicum has potential for the search of new compounds with biological activity
A Case of Primary Tuberculosis of the Paranasal Sinuses
Authors: Yoo Seok Ju , Min Hye Kyu , Kim Sung Wan , Min Jin-Young
Published: August 2024

Tuberculosis of the paranasal sinus is a rare disease caused by infection with Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis. Although the worldwide incidence of tuberculosis is declining, the diagnosis of primary paranasal tuberculosis remains challenging and cannot be ruled out in patients presenting with refractory chronic rhinosinusitis after adequate surgical and medical treatment. We experienced a case of paranasal tuberculosis with no evidence of previous tuberculosis infection. It was diagnosed after a surgical biopsy revealed granulomatous inflammation and caseous necrosis. The patient responded well to antituberculosis drug therapy and became free of symptoms after 7 months of treatment. We report our findings in this case with a review of the recent literature.
Criações com Alice no País das Maravilhas: Professoras de Matemática Pesquisam sobre Relações
Authors: Vilela Denise , Silva Deborah , Araújo Maiara , Vicente Stefhani Emiliani
Published: August 2024

Este artigo faz parte de uma pesquisa mais ampla que aborda relações entre educação matemática e arte tanto na formação do professor como na escola. O estudo se baseia em Experiências Formativas pautadas em perspectivas do filósofo francês Gilles Deleuze, entendendo a aprendizagem como experiência e sentido, transversal e imprevisível e a arte como um disparador de signos O livro Alice no País das Maravilhas, de Lewis Carroll, foi utilizado para movimentar a formação tradicional e excessivamente matemática das professoras Para tanto, professoras de matemática em formação inicial e continuada realizam pesquisas e propõem oficinas focalizando temáticas associadas à obra: lógica e nonsense, noção de tempo, revolução industrial, era vitoriana e relações étnico-raciais. O presente artigo se concentra nesta última, ou seja, em questões atinentes ao racismo e, para isso, também toma uma obra de arte, o quadro denominado A redenção de Cam. A Experiência permitiu vincular o estudo da matemática e da lógica com os paradoxos e o racismo emergente na época em que Carroll escreveu o livro.
Physiological rationale for an effective method of deprogramming the masticatory muscles for persons engaged in strength training
Authors: Stepanov Vasily A. , Ageeva Yulia V. , Shemonaev Viktor I. , Klaucek Sergey V.
Published: August 2024

The study is devoted to the topical issue of physiological justification for the use of various methods for relaxation of masticatory muscles in a state of hypertension in individuals engaged in strength training. Data are presented on a comparative analysis of the effectiveness of the effects of the following deprogramming devices on the masticatory muscles: “Aquasplint”, muscle relaxation mouthguard and transcutaneous electrical neurostimulation, according to electromyography of the masticatory muscles and Dopplerography of the superficial temporal arteries. The predominant physiological effectiveness of using a stabilizing mouthguard and transcutaneous electrical neurostimulation as a method of targeted impact on the tone of the masticatory muscles has been established.
Epidemiological situation of natural focal infections in the Volgograd region in 2022
Authors: Smelyansky Vladimir P. , Zhukov Kirill V. , Nikitin Dmitry N. , Kargashin Stanislav A. , Klimina Irina A. , Taratutina Maria N. , Romasova Elena I. , Kondratenko Evgeniya V.
Published: August 2024

The article is devoted to the analysis of the epidemiological situation of natural focal infections (NFI) in the Volgograd region in 2022. Materials and methods: The work used the official statistics of the institutions of Rospotrebnadzor on NFI for 2022. The main research method is epidemiological analysis. Results and discussion: It has been established that the numbers of small mammals, potential carriers of NFI, as well as ixodid ticks in the territory of the Volgograd region in the season of 2022 were higher than the same indicators of the previous year (SIPY). The number of mosquitoes, carriers of arbovirus infections, did not exceed the average long-term indicators in any species. When examining environmental objects for the presence of markers of NFI pathogens, a slight increase in the proportion of positive samples compared to SIPY in all nosological forms was noted. Sporadic cases of West Nile fever (WNF), Crimean hemorrhagic fever (CHF), hemorrhagic fever with renal syndrome (HFRS), ixodes ricinus-borne diseases (TBDs), Q fever have been registered; no cases of tularemia, rabies, leptospirosis were detected. The morbidity rates of the population of the Volgograd region for all NFI were at the level or lower than those for the Russian Federation and the Southern Federal District.
On the assessment of the role of new antibiotics in pharmacotherapy algorithms for complicated intra-abdominal infections (literature review)
Authors: Ortenberg Eduard A. , Khabibrakhmanova Dinara F.
Published: August 2024

The goal: To analyze the topical problems in the use of the newest antibiotics in abdominal surgical interventions and approaches to their solution. Material and methods: The large-scale (as a rule) publications mostly of 2019–2023 on the issue were analyzed. The searching had been executed according to keywords in Pubmed (ncbi.nlm.nih.gov). Findings: Modern protected cephalosporins and carbapenems, as well as eravacycline, appear to be valuable tools in the treatment of surgical intra-abdominal infection, caused in particular by resistant microflora, especially when taking into account local data. The value of tigecycline in this nosology seems less obvious.
Features of the quality of life of first graders taking into account gender differences
and cognitive abilities
Authors: Lebedenko Alexander A. , Ershova Irina B. , Levchin Artem M.
Published: August 2024

The purpose of the study: To study the features of the quality of life of first-graders, taking into account gender differences and cognitive abilities. Design: An open prospective non-randomized comparative clinical trial. Materials and methods: 631 children were examined, students of the first grades of secondary schools without a specialized bias № 110, 83, 75, 67, 9 Rostov-on-Don using the international questionnaire PedsQL 4.0 – Pediatric Quality of Life Inventory. To assess the cognitive development of children, the D. Wexler scale was used with the determination of the intellectual coefficient. Results: First-graders with a high level of cognitive development have reduced indicators of physical and emotional functioning, as well as the overall quality of life score. Girls with a high intellectual coefficient, in comparison with boys, have lower physical, emotional, school functioning and higher indicators of social functioning. The indicators of quality of life in children with a high level of cognitive development do not reflect the same in children who do "excellent". Conclusion: The revealed features of the quality of life of first-graders with different levels of cognitive development require differentiated medical, psychological and pedagogical support of children in this age period and further study of their health.
Physiological concept of modern medical and biological it methods, used at school in physical culture lessons
Authors: Gorelik Viktor V.
Published: August 2024

The physiological substantiation of the use of IT methods, implemented in the form of ACS "Varicard", is given to monitor the adaptation and health of schoolchildren during classes with them in the subject "physical culture" (PK).
The use of the proposed physiological and pedagogical control is aimed at using an individual approach in the selection of motor loads and means of physical activity in accordance with the Federal State Educational Standard, based on the identification of types of autonomic regulation of body functions and the cardiovascular system of those involved.
Informativeness of the LDF method in assessing physical performance
Authors: Ovchinnikova Olga A.
Published: August 2024

In healthy volunteers, physical performance was assessed according to PWC170 tests, maximum oxygen consumption and microcirculation status by laser Doppler flowmetry (LDF) using a computerized LAKK-02 analyzer. The performance indicators corresponded to the norms of the age group, while significant correlations were revealed with the indicators obtained during the LDF, which confirms the informativeness of the method.
Fuchs endothelial corneal dystrophy: aspects of pathogenesis
Authors: Fisenko Natalia V. , Yusef Yusef Naim , Demura Tatiana A. , Subbot Anastasia M. , Novikov Ivan A. , Osipyan Grigory A.
Published: August 2024

Fuchs endothelial corneal dystrophy (FECD) – multigenic bilateral disorder, characterized by dysfunction of corneal endothelium cells (CECs) that eventually results in loss of transparency. Purpose: To evaluate the pathogenesis of FECD with histological and immunohistochemical methods, immunofluorescence, scanning electron microscopy (SEM). Methods: Endothelium–Descemet membrane (EDM) complexes, corneal buttons were obtained from 76 patients (85 eyes) with FECD during keratoplasty and divided into 1A, 2A, 3A groups, 15 EDMs (donor tisuue) – 1B, 2B, 3B groups (control). Morphological (hematoxylin/eosin staining) and immunohistochemical (primary antibodies to cytokeratin AE1/AE3 and vimentin) studies (1A, 1B groups), phase-contrast microscopy and immunofluorescence analysis of tight junction protein ZO-1 (2A, 2B groups), SEM (3A, 3B groups) were performed. Results: FECD is characterized by decline of CECs, cell and nuclear enlargement. Nuclear-cytoplasmic ratio of CECs is relative to control. CECs expression ZO-1 is decreased in the area of guttae ingrowth. Coexpression of cytokeratin AE1/AE3 and vimentin is found. Morphological and immunohistochemical studies show DM’ thickening, stromal and epithelial edema and local fibrosis, vimentin (stromal cells) and cytokeratin AE1/AE3 (epithelium) expression in FECD. Conclusion: Pathogenesis of FECD include CECs’ epithelial-mesenchymal transition, followed by guttae formation – the excrescences, which destroy cytosketon and lead to progressive loss of CECs. Changes in permeability of endothelium cause edema and fibrosis of stroma and epithelial layer.
Penerapan Metode Membacakan Buku Cerita Untuk Meningkatkan Kemampuan Literasi Anak Usia Lima Sampai Enam Tahun di Tk XYZ [Application of the Story Book Reading Method to Improve the Literacy Skills of Five to Six Year Old Children in XYZ Kindergarten]
Authors: Sitohang Eunike Maria Kristine , Listiyani Anastasia , Nurhayati Chicilia
Published: August 2024

The results of the Organization for Economic Co-operation and Development (OECD) research on the literacy test of Indonesia's Program for International Student Assessment (PISA) show that Indonesia's literacy ability is still low. Literacy skills are needed as a twenty one century skill that must be mastered from an early age. One way to increase literacy is to read storybooks. This study aims to analyze the relationship between the method of reading storybooks to early childhood literacy skills. The method used in this study is quantitative descriptive by distributing questionnaires using five Likert scales (always, often, sometimes, rarely, never). The research was conducted in a private kindergarten in Central Jakarta with a research subject of one hundred and nine students. The results of the research obtained are that there is a relationship between the method of reading storybooks to early childhood literacy skills. The longer the duration of reading stories to children, the higher their literacy skills. Therefore, the method of reading storybooks should be done with a longer duration and frequently, so that children's literacy skills can be maximized.
A COMPARATIVE ANALYSIS OF AMERICAN AND CHINESE CULTURES ACROSS SIX DIMENSIONS
Authors:   Faculty of Education and Humanity, Duta Wacana Christian University (UKDW), Yogyakarta, Indonesia, Winardi Andreas
Published: August 2024

In our rapidly advancing global world, technology, transportation, and communication are evolving at an unprecedented pace. Consequently, it has become increasingly common for individuals to work and study in foreign countries. Those who choose to live abroad must possess adaptability and the ability to adjust, as the cultural landscapes of their destination countries can differ significantly from their countries of origin. Notably, individuals from the Eastern Hemisphere may experience stark cultural contrasts when transitioning from their native Eastern culture to a Western culture. This paper aims to compare the cultural dimensions of China, representing Eastern culture, with those of the USA, representing Western culture. The analysis employs Hofstede’s Value Survey Model (VSM, 2013) to evaluate six cultural dimensions. The results reveal striking differences between China and the USA in four dimensions: Power Distance Index (PDI), Individualism (IDV), Long-Term Orientation (LTO), and Indulgence (IDL). Conversely, the two countries exhibit similarities in the dimensions of Masculinity (MAS) and Uncertainty Avoidance (UAI).
Evaluation of Rat Density and the Associated Factors in Leptospirosis Endemic Areas: The First Report on the Use of BI-Index
Authors: Akbar Zainul , Ristiyanto Ristiyanto , Dwi-Handayani Farida , Sayono Sayono
Published: August 2024

Introduction: Leptospirosis is a health problem in tropical countries where rats serve as the reservoir of Leptospira contamination. Previous investigations implementing the Bi-index to assess rat density in Leptospirosis endemic areas are highly limited. This study aimed to use the Bi-index in monitoring rat density and the associated factors in urban Leptospirosis endemic areas. Methods: Four endemic areas in Semarang City were selected as the study sites based on Leptospirosis data in Puskesmas Gayamsari. Live traps were positioned in one case house and 39-49 neighboring houses in a 100m radius, on three consecutive days. Trapped rats were collected for species identification, morphometrics evaluation, and calculation of Bi-index and rat indices, while environmental parameters were obtained through observation. Results and Discussion: 67.1% of participants were women, private employees, and aged 17-55, while trap success ranged from 2.5-26.5% with the Bi, diversity, dominance, and evenness indices of 0.02-0.32, 0.94-1.09, 0.36-0.44, and 0.79-0.96, respectively. Trapped species included Rattus norvegicus, Rattus tanezumi, and Mus musculus with proportions of 61.3%, 34.1%, and 4.7%, respectively. The presence of rats was associated with closeness to the river containing stagnant water, frequent flooding, water entering houses during floods, open trash bins, and rubbish bins around the houses. The high rat density, dominant species, and correlated environmental conditions are strategic targets in controlling Leptospirosis in Semarang City. Conclusion: The rat density (dominated by R. norvegicus) in Semarang City was correlated with water drainage and garbage management, hence further investigation was recommended to determine Leptospira bacterial infection in rodents.
Implementation of Indoor Air Quality Monitoring Systems of Particulate Matter 2.5 Based on the Internet of Things
Authors: Irbah Nafi'atul , Nurika Globila , Ramani Andrei
Published: August 2024

Introduction: Indoor air quality significantly influences human health because humans can do work and rest indoors. Particulate Matter (PM2.5) is ranked 5th as the leading risk factor for death in the world and causes more than 103 million disabilities. PM2.5 concentrations are the highest, so a monitoring system is needed that can monitor air conditions in real-time and continuously. Methods: Research was conducted using the Research and Development (R&D) type. The scope of the research method is making prototypes and fieldtesting tools. Determination of field test locations is based on indicators such as (i) inadequate ventilation in the respondent's house so that air circulation does not run well; (ii) The family room and bedroom are close to the kitchen and waste incinerator, which has the potential to produce PM2.5 pollutants. Data analysis used descriptive analysis to get a picture of indoor air quality. Results and Discussion: The designed monitoring system was calibrated with the Air Quality Monitor 8 in 1 PM2.5 tool. The average PM2.5 concentration measurement for 24 hours showed that all test points exceeded the standard limit. Room 3 (family room) had the highest PM2.5 concentration, while room 4 (bedroom) had the lowest PM2.5 concentration. Conclusion: The area of air ventilation, mining activities, mining product transportation activities, the intensity of watering roadsides and home yards, and cooking activities influence PM2.5 concentrations.
Modal Sosial Keagamaan dan Partisipasi Perempuan Muslim Indonesia dalam Perburuhan
Authors:   Jurusan Ekonomi Pembangunan, Fakultas Ekonomi Universitas Sriwijaya, Sumatra Selatan, Indonesia, Nida Rahma , Yunisvita Yunisvita ,   Jurusan Ekonomi Pembangunan, Fakultas Ekonomi Universitas Sriwijaya, Sumatra Selatan, Indonesia, Gustriani Gustriani ,   Jurusan Ekonomi Pembangunan, Fakultas Ekonomi Universitas Sriwijaya, Sumatra Selatan, Indonesia
Published: August 2024

Dalam beberapa tahun terakhir, fokus negara-negara mayoritas muslim pada partisipasi angkatan kerja perempuan telah berkembang, terutama Indonesia dengan tingkat partisipasi angkatan kerja perempuan yang tinggi. Penelitian ini bertujuan untuk menjelaskan hubungan antara agama dan keputusan kerja di Indonesia menggunakan data dari World Value Survey dan analisis regresi logistik. Temuan penulis mengungkapkan bahwa partisipasi aktif dalam kegiatan keagamaan berdampak positif terhadap kemungkinan perempuan muslim bekerja paruh waktu dan di sektor pertanian. Melalui hasil penelitian ini, pembuat kebijakan dan pemangku kepentingan terkait dapat mempertimbangkan untuk memanfaatkan organisasi keagamaan sebagai saluran potensial untuk mempromosikan partisipasi angkatan kerja perempuan.
Disability in the Qur'an Manifestation of Repositioning from Exclusive to Inclusive
Authors: Puspitasari Niken Sylvia , Irfan Muhammad Zaidan , Al Faritzi Muhamad Redho
Published: August 2024

This research is motivated by the rise of ableism. This research aims to discover Disability in the Qur'an Manifestation of Repositioning from Exclusive to Inclusive. This research uses library research by making the library the primary source for obtaining data.  This research uses a qualitative approach to examine the theme of disability in the Qur'an and how the sacred text can be understood in a modern context as an effort to reposition from exclusive to inclusive. The results show that the Qur'an has many words for disability, namely, a'ma/ umyun, akmah, bukmun, shummun, and a'raj. There are 38 verses spread across 26 surahs of the Quran. There are four verses in the entire Qur'an about a person that speaks directly about their attitude towards a disabled person or refers to a person with a physical disability. The Qur'an sees people with disabilities as having to be tolerant like ordinary people or behave equally towards others, especially those who are weak to discrimination, which is a manifestation of the repositioning of exclusive to inclusive.