bluuebunny/crossref_metadata_2025 huggingface dataset:
RISK ASSESSMENT APPLICATION IN MILLING MACHINES
Authors: BAĞIRAN Hamdi Emre
Published: April 2023

Machine tools, which are indispensable parts of the machinery and metal production sector, are frequently used in the sector. Workplaces in the sector are in dangerous and very dangerous classes in terms of their activities, and therefore, it is inevitable that work accidents and occupational diseases occur frequently in machine tools where production is made. For this reason, risk assessment has become the most important requirement in order to minimize the physical, chemical and ergonomic risks that already exist in machine tools and originate from use, and to establish an occupational health and safety climate in the sector. In this study, universal and CNC (Computer Numerical Control) controlled milling machines, which are used in a university laboratory, where most of the production is carried out in the sector and therefore one of the most frequently used machine tools, are discussed and risk assessment with Fine-Kinney method, which is one of the most frequently used risk assessment methods in the sector has been made. A total of 23 risks have been identified, corrective/preventive actions necessary to prevent existing hazards and reduce risks have been explained and solutions have been presented. With this study, it is aimed to raise the necessary awareness to the employees by evaluating the milling machines, which are frequently used in the sector, both in production and in the laboratories for educational purposes, in terms of occupational health and safety.
A educação permanente como ferramenta de enfermagem na melhoria da assistência à saúde na Atenção Básica: revisão integrativa
Authors: Pereira Bárbara Marianna Passos , Rocha Aline de Sousa , Gomes Benedita Maryjose Gleyk , Sousa Roberta Meneses , Batista Marcos Antonio Silva , Gonçalves Rosane Cristina Mendes , Teixeira Fernanda Viana , Almeida Joelma Dias , Holanda Lucas Sousa de , Lima Leila Sousa
Published: April 2023

A Educação Permanente em Saúde (EPS) vem se tornando cada vez mais essencial, especialmente quando se fala de prevenção de agravos e promoção a saúde. Uma vez que, este fator sai do contexto do saber científico e engloba diversos alicerces entre a realidade e experiência de cada indivíduo presente, solicitando o encontro de uma solução para a problemática enfatizada. Dessa forma, quanto mais conhecimento a respeito da realidade de determinado ambiente, maior a probabilidade da realização do cuidado qualificado e efetivo, sobretudo na Atenção Básica. O objetivo desse estudo é: abordar a EPS como ferramenta de enfermagem, para a melhoria da assistência à saúde na Atenção Básica. Metodologia: Trata-se de uma revisão integrativa de literatura com abordagem qualitativa, realizada por meio do levantamento de oito estudos publicados entre os anos de 2016 a 2021, nas seguintes plataformas: BVS (Biblioteca Virtual de Saúde) e SCIELO: (Base de Dados Bibliográfico), utilizando os seguintes Descritores em Ciências da Saúde (DeCS): Atenção Básica, Educação Permanente e Qualidade da Assistência, nos idiomas português e inglês. A análise dos dados ocorreu por meio da estratégia PICO (P –população; I – intervenção/área de interesse; C – comparação; O – outcomes/desfecho). Resultados: Os oito estudos são publicados na língua portuguesa. Os artigos analisados evidenciam o uso da Educação Permanente como ferramenta de enfermagem na Atenção Básica, apontando benefícios como melhora da assistência, estímulos de reflexão e capacidade de traçar objetivos. Conclusão: A utilização da Educação Permanente em saúde por enfermeiros na Atenção básica é considerada pertinente, especialmente quando aplicada de forma correta.
Aplicativos móveis para estimulação cognitiva de idosos em processo demencial: uma revisão sistemática
Authors: Silva Neto Francisco Soares da , Jesuíno Ana Deyvis Santos Araújo , Amorim Diane Nogueira Paranhos , Silva Marcello de Alencar
Published: April 2023

Objetivo: averiguar a existência de um aplicativo que auxilie, cognitivamente, idosos em estágio demencial leve. Método: buscou-se analisar os estudos existentes sobre a utilização de aplicativos móveis na promoção de desenvolvimento cognitivo de idosos que estejam em processo demencial inicial. Desse modo, este estudo consiste em uma pesquisa no formato de Revisão Sistemática da Literatura (RSL) que seguiu as diretrizes do protocolo PRISMA. As buscas foram realizadas em março de 2022, nas bases de dados eletrônicas “LILACS”, “Scopus”, “SciELO”, “PEPSIC”, “PUBMED”, “Web of Science” e “PKP (Publik Knowledge Project)”. Resultado: a análise constatou que há a existência de algumas aplicações móveis voltadas para esse intuito, porém muitas estão em desenvolvimento ou necessitam de aprimoramentos. Conclusão: faz-se necessário que haja tanto o avanço das ideias de aplicações móveis já existentes, quanto a criação de aplicações móveis que realmente auxiliem no cotidiano dos idosos em estágio demencial, propiciando uma melhor qualidade de vida para esses e uma estimulação cognitiva diária.
Produção caseira de bebidas fermentadas: uma alternativa biotecnológica para melhorar a saúde em comunidades carentes brasileiras
Authors: Suhre Taís , Hickert Lilian Raquel
Published: April 2023

Este estudo apresenta a possibilidade de ampliar o consumo de bebidas fermentadas, como kombucha e kefir de água, para melhorar a saúde em comunidades carentes do Brasil. O objetivo é demonstrar a importância de realizar esforços para tornar essas bebidas saudáveis amplamente disponíveis, especialmente para populações com alto risco de morbidade e mortalidade, em substituição ao consumo excessivo de refrigerantes. A abordagem metodológica qualitativa utilizada caracteriza o estudo como uma revisão bibliográfica. As conclusões do estudo apontam que devem ser adotadas estratégias que enfatizem para os consumidores os problemas relacionados ao consumo excessivo de bebidas e alimentos com alto teor de açúcares e estimulem a substituição dos refrigerantes convencionais por bebidas saudáveis. Além disso, aponta como perspectiva o desenvolvimento de ações educacionais, como oficinas de produção caseira de bebidas fermentadas, a fim de ensinar a população sobre os benefícios de alimentos e bebidas funcionais para a saúde. Por fim, se posiciona como material de consulta para discussões adicionais e futuras elaborações de políticas públicas que estimulem a produção e consumo dessas bebidas pela população brasileira.
Inovasi Jambu Kristal serta Pengolahan Sampah Jambu Kristal menjadi Eco Enzim di Desa Bantarsari Kabupaten Bogor
Authors: Suyana Hilma , Budiman Andika Nuraga , Nurhayati Ely
Published: April 2023

Mitra dalam Program Kemitraan Masyarakat ini adalah Petani Jambu kristal di Desa Bantarsari Kabupaten Bogor, UMKM di Desa Bantarsari berupaya memajukan usaha jambu kristal menjadi usaha yang maju untuk kedepannya dengan memberikan brand dan packing kepada usaha jambu kristal dan memasarkan secara digital serta bagaimana mengolah sampah jambu kristal menjadi eco enzim bagi para UMKM. Metode pelaksanaan Program Kemitraan Masyarakat ini dilakukan melalui pelatihan dan pendampingan. Luaran yang dihasilkan dari PKM ini adalah adanya brand dan packing untuk produk jambu kristal, serta bagaimana mengolah limbah dari jambu kristal menjadi produk yang mempunyai nilai tambah atau lebih dikenal dengan eco enzim. Selain melakukan pelatihan dan pendampingan para mitra juga diberikan pelatihan untuk memaksimalkan daun jambu kristal. Di dalam buah jambu kristal terkandung vitamin c sebagai antioksidan yang mampu mencegah penuaan dan potasium untuk menurunkan tekanan darah. Sedangkan dalam daunnya terdapat polifenol sebagai penurun gula darah dan antioksidan serta adanya tani untuk mencegah diare. Tidak hanya buah jambu kristal saja yang bisa diolah menjadi berbagai banyak olahan tetapi juga daun dari jambu kristal tersebut juga bisa di proses untuk pembuatan teh jambu kristal. Pada dasarnya serupa dengan pengolahan teh ocha yang merupakan teh khas di Jepang. Salah satunya adalah pemijatan daun agar jaringannya pecah sehingga aromanya muncul. Pada tahap akhir pengolahan, teh bisa dijemur maupun disangrai.
Peningkatan Kepatuhan Minum Obat Antiretroviral (ARV) dan Pengembangan Pola Asuh Anak dengan HIV Positif di Jabodetabek
Authors: Trisiswati Maya , Herlinawati Sri Wahyu , Suhaeri Suhaeri , Pradina Tiara Aulia
Published: April 2023

Epidemi HIV/AIDS berdampak peningkatan jumlah kasus Ibu RumahTangga dan anak terinfeksi. Anak menjadi populasi rentan karena ancaman penularan bisa dari dalam kandungan, persalinan dan ASI. Kepatuhan minum ARV menghambat replikasi virus sehingga jumlahnya tertekan dan tidak terdeteksi pemeriksaan darah sehingga virus tidak menularkan. Kepatuhan ARV anak bergantung dari ibu atau pengasuhnya serta pola asuh yang diterimanya. Kemenkes RI mencatatkan 28% ODHIV patuh ARV dari target 80% . Data nasional sebanyak 8050 (usia 0-14 tahun) terinfeksi HIV dan DKI Jakarta sebanyak 1026 orang. Rendahnya pengetahuan kepatuhan minum obat dan pola asuh yang dimiliki merupakan masalah yang harus segera diselesaikan. Tujuan penelitian ini adalah untuk meningkatkan pemahaman Ibu/pengasuh tentang kepatuhan minum obat, mengembangkan pola asuh dan pendampingan Ibu HIV positif melalui pelayanan konseling. Metode yang digunakan adalah edukasi tatap muka, konseling dan pendampingan. Hasil menunjukkan bahwa adanya peningkatan pemahaman Ibu/pengasuh anak tentang HIV khususnya kepatuhan minum ARV, pengembangan pola asuh. Pendampingan melalui pelayanan konseling. Edukasi Peningkatan Kepatuhan ARV dan Pengembangan Pola Asuh efektif.
STAFFING OF PUBLIC ADMINISTRATION BODIES IN THE CONTEXT OF THE DEVELOPMENT OF A DIGITAL SOCIETY
Authors: KHARECHKO DMYTRO , NIEMA OLEKSANDRA , KHUDOBA OLEKSANDRA , ZAYATS DIANA , OLEFIRENKO OLHA , BUDZYN VIRA
Published: April 2023

The article demonstrates the essence of public administration staffing, indicates its role and necessity in modern realities. The priority tasks of personnel policy in the context of the digital transformation of society, and its continuous dynamics, are given. The issues of competence of civil servants of the digital era are considered. The problem of reducing the attractiveness of employment in the bodies of public management in the eyes of a new generation of labor market participants, as well as the challenge of quit rate increase, is analyzed. Within the paradigm of New Public Management, based on the latest trends in human resource management – Agile approach and Talent Marketplaces – the necessity of transforming employee value proposition in the public sector is outlined.
New Evidence for Exogenous Glycosaminoglycans Treatment of ‘Cystitis’: Is the Future Now?
Authors: Lazzeri Massimo , Van Kerrebroeck Philip
Published: April 2023

Chronic cystitis may be due to different known causes. Current basic science research has revealed a wide consensus that chronic cystitis may arise from a primary defective urothelium lining and in particular from a damage of its glycosaminoglycans (GAGs) component. The GAG layer is composed mainly of heparin, dermatan, the glycosaminoglycans, chondroitin sulphate (CS), and hyaluronic acid (HA) which adhere to the surface of the urothelium. The main components, CS and HA, play a central role in the urine barrier and antibacterial defence mechanisms. When the GAG layer loses its protective barrier function it translates into increasing permeability of the urothelium. The main consequence of this is that bladder inflammation may arise. Exogenous restoration of the GAG layer has recently become a new opportunity for the treatment of recurrent urinary tract infections, painful bladder syndrome or interstitial cystitis, and lower urinary tract symptoms after chemotherapy or pelvic radiotherapy. The aim of this paper is to update the literature about the use of exogenous for the treatment of cystitis.
Unravelling the Mystery Between Structure and Sustained Clinical Outcomes
Authors: Driscoll Clare
Published: April 2023

Targeted biologics have revolutionised the treatment and outlook of patients with inflammatory joint diseases. The combination of high-cost long-term therapy straining healthcare systems with impending expiry of key biologics patents has led to heightened interest in the development of biosimilars. The expanding landscape of biosimilars has triggered, in healthcare providers, the need to explore the option to non-medically switch stable patients from costly reference products to less expensive alternatives. Currently, there are many unknowns surrounding the effects of non-medical switching on patient outcomes and cost-effectiveness. Prof Edward Keystone opened the symposium by discussing the constantly evolving landscape of biologics, highlighting that their high cost is becoming an increasing challenge and has created the issue of non-medical switching. Dr Leigh Revers provided a background to the structural and functional relationships of biologic therapies, stressing the need for careful control of the manufacturing processes of these large and complex molecules. Prof Keystone presented the long-term data currently available for anti-tumour necrosis factor (anti-TNF) agents and examined how sustainability of response can be influenced by multiple factors. Prof Thomas Dörner concluded the symposium by stressing the importance of the prescribing doctor being in control of which biologics their patients receive to ensure effective pharmacovigilance. The challenge of non-medical switching was discussed along with the potential trial designs that could help to determine if biologics and biosimilars could be interchangeable.
GreenLight XPS™ Vaporisation of the Prostate Has Proven Cost-Effective
Authors: Muir Gordon , Barber Neil , Thomas James Andrew , Giona Simone
Published: April 2023

Benign prostatic hyperplasia (BPH) is common in men aged >60 years, affecting urinary and bladder function. Due to the progressive nature of the disease, many men initially treated with conservative therapies require surgical intervention for symptom relief. Less invasive techniques, such as transurethral microwave therapy, needle ablation, transurethral resection of the prostate (TURP), and laser treatment, have been developed with TURP being the standard of care for BPH in Europe in prostates <80 mL (volume). For an increasingly ageing male population often receiving anticoagulants for cardiovascular comorbidities, TURP may not be suitable due to high risk of bleeding, requirement for bladder washouts, and blood transfusions. Owing to these requirements and potential complications associated with surgery, TURP is performed as inpatient surgery requiring a 2 to 4-day hospital stay. In the GOLIATH study, the 180 W GreenLight XPS™ laser system demonstrated comparable efficacy with TURP at 6 and 12 months, while maintaining low rates of adverse events, retreatments, or postoperative interventions in low-risk patients. Recovery parameters significantly favoured GreenLight XPS over TURP, thus greatly supporting GreenLight XPS use for BPH treatment during short-term stay. There is a requirement for healthcare services to minimise costs. Estimated on a day-case basis, GreenLight XPS was significantly more cost-effective than TURP with a 25% reduction in procedural cost, lower indirect costs, and lower financial burden based on efficacy and adverse-event outcomes. Therefore, GreenLight XPS represents an appropriate treatment option for day-case surgery and a treatment that can be tailored to individual patient needs.
A Study on the Development and Utilization of Contents for Neolithic Education
Authors:   The Korean Society of Culture and Convergence, kim sanghoon , Ahn HyoungKi
Published: April 2023

The purpose of this paper is to finding ways to develop and utilize educational contents targeting the Neolithic Age. Korea's Neolithic period corresponds to around 8000 B.C. to 2000 B.C. Since the 2000s, related excavations have steadily increased, and many research achievements have been accumulated. However, educational content for educating the public on the Neolithic lifestyle has thus far been limited. In order to overcome a lack of content and technology seen in Neolithic educational content thus far, this paper has proposed artificial intelligence XR-based metaverse digital content. It is expected that if the contents are organized in the way suggested via this text, and digital technology is introduced and applied properly in the future, it will be possible to provide a more educational and vivid digital cultural heritage to the public. What’s more, it is possible to expand upon and apply this content creation to the restoration and experience of life in other eras.
Exploring Generational Theory in Artists' Perception of Occupational Identity and Art Labor: for the second generation around the age of 40
Authors:   The Korean Society of Culture and Convergence, Paek Mihyun
Published: April 2023

The purpose of this study is to explore the generational theory of artists' job identity and perception of artistic labor, and 16 artists around the age of 40 (30-59) were interviewed in-depth to interpret their perceptions. As a result of the study, no clear generational theory was confirmed around the age of 40. The same perception without generational differences is first, most of the participants consider the artist job to be an “incomplete” job that cannot be compensated for their livelihood, and hope to become a “full-time Artist” before they die. Second, they pursue the spirit of “spirit of freedom of pure creation” derived from the myth of poor genius artists. On the other hand, the perception of the artist welfare system showed a generation gap in “interest” and “experience” around the age of 44, and “in-generation conflict” before the age of 44 was confirmed in terms of “awareness.” In addition, 'side jobs to maintain artistic creativity' have now been promoted to names such as 'second jobs', and 'main jobs' alongside artist job.
Contemporary Aesthetic Pathology: Fight, Sublime, Anger
Authors:   The Korean Society of Culture and Convergence, Kwon Juria
Published: April 2023

This study defines 21st century as a society of aesthetic pathology that derives pleasure from misery and disgust. This is because it is difficult to approach the totality of modern society without describing ugliness in it. To this end, in the webtoon Self-taught Fight, the three-step themes of fight, sublimity, and anger are examined. In ‘Bad Girl and Fighting Influencer’, the fight between bad girls is recognized not as an ethical point of view between good and evil, but as a political act that reorganizes the order of power through the body. In 'The Sublime and the Equality of the Senses', we find the climax of the sublime where a terrifying intoxication occurs in a grotesque fight scene. In this process, the subject of the fight regains the share of the senses from the invisible to the visible. In ‘Publicity of Anger’, it is expressed in the form of violence, but paradoxically, the impulse to sympathize with the world is inherent in anger.
Qualitative Meta-Sumary of Alcholism Recovery Experiences
Authors:   The Korean Society of Culture and Convergence, Kim Minseog
Published: April 2023

The purpose of this study is to identify key experiences found in domestic qualitative studies on recovery from alcoholism and to derive recovery support measures based on them. To achieve this research purpose, this study applied a qualitative meta-summary. Qualitative meta-summary is a method that summarizes the results of various qualitative studies into abbreviated statements and calculates the size of the frequency effect for each abbreviated statement to identify more core experiences in the research area. As a result of examining the abbreviated statements with a large frequency effect, the core recovery experience was the experience of deciding to abstain from drinking through repeated relapse experiences, self-understanding and acceptance. When comparing the new concept of recovery with the core experiences found in this study, it was confirmed that the recovery experiences found in Korea do not show respect for the diversity of recovery experiences and promote a positive outlook on recovery. Based on the results of this analysis, this study discussed the importance of the expansion of recovery support services and advocacy movements.
A Study of Teaching and Learning Methods for Convergence Education in Beauty Major to Manage the 2022 Revised Curriculum and Vocational High School Credit System
Authors:   The Korean Society of Culture and Convergence, Lee Sangwon , Kwon Kihan
Published: April 2023

The purpose of this study is to propose a curriculum of convergence subjects in the beauty major, and specific teaching-learning methods, following the introduction of the 2022 revised curriculum and high school credit system. Considering precedent researches, subjects(departments) for convergence education with beauty subjects were selected as follows: photography․film, culture․arts․design․broadcasting, health․welfare, chemical industry. Competency units were selected, considering academic connectivity between subjects with the learning themes related to real life, focusing on similarity and relevance to each other. Then, a lesson plan was made. Lastly, the suitability of the lesson plan was verified through a survey using SPSS 22 with teachers of each department. This study is expected to be helpful to manage lessons of the high school credit system in vocational high school. Additionally, Ministry of Education is asked to provide teachers’ training and support financially and administratively for the effective and efficient substantialization.
Study on Kim Jong-Gi Geomungo Sanjo Melody: Focused On Danmori
Authors:   The Korean Society of Culture and Convergence, yun wuni
Published: April 2023

Geomungo Sanjo was created by Baek Nak-jun in 1896, and in the case of Kim Jong-gi, one of his students, geomungo sanjo was not confirmed, but he tried to find out his rhythm by checking the record published by Okeh Records later. The scope of this author's research is Kim Jong-gi's Geomungo Sanjo Danmeori, and the research method is to transcribe literature and sound sources to study melody progression and scales used. As a result of the study, the Sang rhythm consists of a total of 8 paragraphs and 91 rhythms, and the Mi scale C main cheong Gyemyeonjo constructive sound, Mi(g) - Sol(b♭) - La(c) - Si(d) - Do(e♭) - Re(f) proceeds to the melody, in the Ha rhythm, consists of a total of 8 paragraphs and 107 rhythms, and an of the alteration only in the third paragraph, the sol scale e♭ main cheong woojo construvtive sound Sol(b♭) - La(c) - Do(e♭) - Le(f) - Mi( g) It was found that a change in composition occurred.
A quantitative approach to doublets in Russian denominal adjective construction
Authors: Bobkova Natalia , Montermini Fabio
Published: April 2023

This article is devoted to the rivalry between suffixes in the derivation of denominal adjectives in Russian. In particular, it proposes a large-scale quantitative analysis based on the Russian National Corpus. Its main goal is to contribute to identifying the properties that determine the choice of the suffix in these derivatives. Denominal adjectival derivation in Russian makes use of a wide variety of exponents. Most of them are phonological variants (extensions) of three main suffixes, - n-, - sk- and - Ov-. These three, which can be considered as basic, constitute the focus of our analysis. Two datasets were built for this research, a general one containing one of the suffixes above, and a more specific one containing doublets, which is to say, adjectives constructed on the same base with different suffixes. Data from the two sets are analyzed by means of various statistical models. Our results globally provide a quantitatively robust confirmation of observations previously made in the literature. In particular, we show that -n- occupies a specific position in the derivational system of Russian, as it is less productive and its derivatives are tendentially less transparent and more prone to display lexicalized meanings that point towards the qualitative pole of the qualitative-relational semantic spectrum. Moreover, - sk- and - Ov- are more likely to form doublets (be attached to the same bases), a further argument in favor of a greater homogeneity between them as opposed to - n-.
Mental disorder: An ability-based view
Authors: Dembic Sanja
Published: April 2023

What is it to have a mental disorder? The paper proposes an ability-based view of mental disorder. It argues that such a view is preferable to biological dysfunction views such as Wakefield’s Harmful Dysfunction Analysis and Boorse’s Biostatistical Theory. According to the proposed view, having a mental disorder is basically a matter of having a certain type of inability (or: an ability that is not sufficiently high): the inability to respond adequately to some of one’s available reasons in some of one’s reasons-sensitive attitudes or actions, where the threshold of inability is determined by one’s being harmed. The relevant concepts of inability, reasons, and harm are sketched. The paper argues that the proposed view evades some problems of biological dysfunction views by remaining neutral on questions of causation and the evolution of the mind. Furthermore, it can capture better what is distinctively “mental” about mental disorder. On the proposed view, it is the rational relations among an individual’s attitudes and actions that are “disordered” and the relevant norms in mental disorder are the norms of reasons. As further merits, the view can account for degrees of disorder, incorporate biological as well as social aspects, and elucidate the relations among disorders, symptoms, and their causes.
ABILITY, MOTIVATION, OPPORTUNITY-ENHANCING HRM PRACTICES AND CORPORATE ENVIRONMENTAL CITIZENSHIP: REVISITING THE MODERATING ROLE OF ORGANISATIONAL LEARNING CAPABILITY IN MALAYSIAN CONSTRUCTION COMPANIES
Authors: Tay Lee Chin  , Tan Fee Yean  , Hon-Wei Leow
Published: April 2023

This study examines the connection between ability, motivation, opportunity-enhancing HRM practices and corporate environmental citizenship. Organisational learning capability is also introduced as a moderator between the connections of AMO-enhancing HRM practices and corporate environmental citizenship. Systematic sampling technique was utilized to determine the study sample with a total response of 150. The study found that ability and opportunity-enhancing HRM practices are related to corporate environmental citizenship except for motivation-enhancing HRM practices. Similarly, organisational learning capability has no moderating effect on such relationships. In addition to that, this study has provided a comprehensive understanding of corporate environmental citizenship in the construction industry in Malaysia. This substantially adds a new dimension to the literature.
MANAGERIAL CAPABILITIES, LEARNING ORIENTATION AND PERFORMANCE OF INTERNATIONAL HALAL INDUSTRY USING UPPER ECHELON THEORY
Authors: Mazida Ismail  , Norhidayah Mohamad  , Amiruddin Ahamat
Published: April 2023

Upper echelon theory (UET) emphsizes the role of management in determining firm strategy that can lead to performance. Many studies have been conducted on UET but very few have addressed UET in international business research, especially in the halal industry. Implementing learning orientation as a culture can serve as a medium in transferring tacit knowledge within the firm. Therefore, this research was conducted to examine the mediating effect of learning orientation between managerial capabilities and international firm performance of small and medium-sized enterprises (SMEs) in the halal industry. This is a quantitative, cross-sectional study with a total of 136 responses analyzed using PLS-SEM. The results show that the impact of top-management team’s (TMT) knowledge of foreign markets on international firm performance depends on learning orientation and partially mediates the relationship between TMT’s international experience and international firm performance. The study is novel in that it tests UET in the halal industry and introduces a new mediator to the UET framework.
UNEMPLOYMENT BEHAVIOUR IN THE COVID-19 PANDEMIC: EVIDENCE FROM DEVELOPING COUNTRIES
Authors: Chor Foon Tang  , Salah Abosedra
Published: April 2023

This paper explores the impacts of the COVID-19 pandemic, corruption and other determinants on unemployment in developing countries using panel dataset for 89 developing countries from January to December 2020. The proposed unemployment model is estimated utilising a newly formulated conceptual framework to examine whether COVID-19 pandemic, corruption, and human capital, play a moderating role on unemployment determination in our selected developing countries. The model is estimated using the dynamic panel system generalised method of moments (GMM) estimator. Apart from output, inflation and human capital, our results show that the COVID-19 pandemic and corruption are major variables in explaining the unemployment rate for our sampled countries. Furthermore, and more notably, we find evidence that the COVID-19 pandemic and corruption appear to significantly restrain and alter the role of outputs and human capital in impacting unemployment. Therefore, the detrimental effects of the COVID-19 pandemic and corruption on the economies and labour markets of countries examined should not be under-estimated. Additionally, findings show that, while policy initiatives to combat the COVID-19 pandemic are critical, strengthening anti-corruption regulations would further improve the efficiency of any attempt to reduce unemployment rates associated with the COVID-19 period.
LINKING THE ANTECEDENTS OF A KEY PLAYER IN NATIONAL’S PALM OIL SECTOR IN ACHIEVING COMPETITIVE ADVANTAGE: MODERATING EFFECTS OF ORGANISATION’S AGE
Authors: Mohd Nazir Rabun  , Mohd Ramlan Mohd Arshad  , Muhammad Hanif Othman
Published: April 2023

The concept of strategic positioning as a fundamental element in strategic management used to understand one of the government agencies, the key player in the plantation industry, determines its external environment, internal strategic capabilities factors and understanding its stakeholders' influences-expectations towards achieving competitive advantage. This study aims to examine all the competencies level and the correlation between the external environment, internal strategic capabilities, and understanding its stakeholders' influences-expectations and achieving competitive advantage. This study tries to examine the moderating variable that could affect the relationship between determinants of strategic positioning and achieving competitive advantage, namely the organisation’s age. This study employed quantitative and qualitative approaches by using triangulation techniques. Through cross-sectional design, there were 162 completed survey questionnaires returned, but only 150 were useable. The data collections conducted through interviews with the Agency's Board members and surveys. The survey questionnaires distributed to managers who are involved and engaged in the planning and the implementation of strategies/policies relating to the Agency. Findings indicate that the internal strategic capabilities which had created an important correlation in organisations for realising competitive advantage. Besides, the findings demonstrate the indirect effect of age of organisation in the relationship between all the determinants and their position to achieve competitive advantage. Finally, the research outcomes of this study will hopefully provide the reference to other public sector organisations to emulate the model of the Agency in positioning its organisation.  It also hoped to set a direction and roadmap for the Agency to go forward as well as enable them to compete domestically and internationally on the scale of competitions.
Investigating students' vocabulary learning through captioning in social media
Authors: Setiawati Rini , Sunra La
Published: April 2023

This research aims to describe the students' perspective on the use of captions in social media in learning English vocabulary, the EFL teachers' perspective on the use of captions in social media in teaching vocabulary, and the impact of the use of social media as a teaching and learning tool for English vocabulary. This research is a descriptive qualitative research design. Purposive sampling was used to collect samples from the teachers and students at the XII grade of one of the Vocational High Schools in Makassar, South Sulawesi, Indonesia. The instruments used in this research were an interview protocol and an observation checklist. The data showed that all students perceived social media captions helped them acquire vocabulary since the content was engaging, the learning materials were well-presented, and plenty of resources were available. In addition, the teachers stated that online teaching and learning have several advantages and disadvantages when using some media as their teaching strategy. Finally, vocabulary learning through social media positively impacts students' acquisition of more vocabulary. Vocabulary learning through social media captions is important for increasing students' vocabulary. Both teachers and students agree that captions on social media are extremely useful in teaching and learning.
Alpha-SNAP (M105I) mutation promotes neuronal differentiation of neural stem/progenitor cells through overactivation of AMPK
Authors: Bustamante-Barrientos Felipe A. , Méndez-Ruette Maxs , Molina Luis , Koning Tania , Ehrenfeld Pamela , González Carlos B. , Wyneken Ursula , Henzi Roberto , Bátiz Luis Federico
Published: April 2023

Background: The M105I point mutation in α-SNAP (Soluble N-ethylmaleimide-sensitive factor attachment protein-alpha) leads in mice to a complex phenotype known as hyh (hydrocephalus with hop gait), characterized by cortical malformation and hydrocephalus, among other neuropathological features. Studies performed by our laboratory and others support that the hyh phenotype is triggered by a primary alteration in embryonic neural stem/progenitor cells (NSPCs) that leads to a disruption of the ventricular and subventricular zones (VZ/SVZ) during the neurogenic period. Besides the canonical role of α-SNAP in SNARE-mediated intracellular membrane fusion dynamics, it also negatively modulates AMP-activated protein kinase (AMPK) activity. AMPK is a conserved metabolic sensor associated with the proliferation/differentiation balance in NSPCs.

Methods: Brain samples from hyh mutant mice (hydrocephalus with hop gait) (B6C3Fe-a/a-Napahyh/J) were analyzed by light microscopy, immunofluorescence, and Western blot at different developmental stages. In addition, NSPCs derived from WT and hyh mutant mice were cultured as neurospheres for in vitro characterization and pharmacological assays. BrdU labeling was used to assess proliferative activity in situ and in vitro. Pharmacological modulation of AMPK was performed using Compound C (AMPK inhibitor) and AICAR (AMPK activator).

Results: α-SNAP was preferentially expressed in the brain, showing variations in the levels of α-SNAP protein in different brain regions and developmental stages. NSPCs from hyh mice (hyh-NSPCs) displayed reduced levels of α-SNAP and increased levels of phosphorylated AMPKα (pAMPKαThr172), which were associated with a reduction in their proliferative activity and a preferential commitment with the neuronal lineage. Interestingly, pharmacological inhibition of AMPK in hyh-NSPCs increased proliferative activity and completely abolished the increased generation of neurons. Conversely, AICAR-mediated activation of AMPK in WT-NSPCs reduced proliferation and boosted neuronal differentiation.

Discussion: Our findings support that α-SNAP regulates AMPK signaling in NSPCs, further modulating their neurogenic capacity. The naturally occurring M105I mutation of α-SNAP provokes an AMPK overactivation in NSPCs, thus connecting the α-SNAP/AMPK axis with the etiopathogenesis and neuropathology of the hyh phenotype.
Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus)
Authors: Shylo Natalia A. , Smith Sarah E. , Price Andrew J. , Guo Fengli , McClain Melainia , Trainor Paul A.
Published: April 2023

The ancestral mode of left-right (L-R) patterning involves cilia in the L-R organizer. However, the mechanisms regulating L-R patterning in non-avian reptiles remains an enigma, since most squamate embryos are undergoing organogenesis at oviposition. In contrast, veiled chameleon (Chamaeleo calyptratus) embryos are pre-gastrula at oviposition, making them an excellent organism for studying L-R patterning evolution. Here we show that veiled chameleon embryos lack motile cilia at the time of L-R asymmetry establishment. Thus, the loss of motile cilia in the L-R organizers is a synapomorphy of all reptiles. Furthermore, in contrast to avians, geckos and turtles, which have one Nodal gene, veiled chameleon exhibits expression of two paralogs of Nodal in the left lateral plate mesoderm, albeit in non-identical patterns. Using live imaging, we observed asymmetric morphological changes that precede, and likely trigger, asymmetric expression of the Nodal cascade. Thus, veiled chameleons are a new and unique model for studying the evolution of L-R patterning.
Modelling the erythroblastic island niche of dyserythropoietic anaemia type IV patients using induced pluripotent stem cells
Authors: May Alisha , Ventura Telma , Fidanza Antonella , Volmer Helena , Taylor Helen , Romanò Nicola , D’Souza Sunita L. , Bieker James J. , Forrester Lesley M.
Published: April 2023

Introduction: Congenital dyserythropoietic anaemia (CDA) type IV has been associated with an amino acid substitution, Glu325Lys (E325K), in the transcription factor KLF1. These patients present with a range of symptoms, including the persistence of nucleated red blood cells (RBCs) in the peripheral blood which reflects the known role for KLF1 within the erythroid cell lineage. The final stages of RBCs maturation and enucleation take place within the erythroblastic island (EBI) niche in close association with EBI macrophages. It is not known whether the detrimental effects of the E325K mutation in KLF1 are restricted to the erythroid lineage or whether deficiencies in macrophages associated with their niche also contribute to the disease pathology.

Methods: To address this question, we generated an in vitro model of the human EBI niche using induced pluripotent stem cells (iPSCs) derived from one CDA type IV patient as well as two iPSC lines genetically modified to express an KLF1-E325K-ERT2 protein that could be activated with 4OH-tamoxifen. The one patient iPSC line was compared to control lines from two healthy donors and the KLF1-E325K-ERT2 iPSC line to one inducible KLF1-ERT2 line generated from the same parental iPSCS.

Results: The CDA patient-derived iPSCs and iPSCs expressing the activated KLF1-E325K-ERT2 protein showed significant deficiencies in the production of erythroid cells with associated disruption of some known KLF1 target genes. Macrophages could be generated from all iPSC lines but when the E325K-ERT2 fusion protein was activated, we noted the generation of a slightly less mature macrophage population marked by CD93. A subtle trend in their reduced ability to support RBC enucleation was also associated with macrophages carrying the E325K-ERT2 transgene.

Discussion: Taken together these data support the notion that the clinically significant effects of the KLF1-E325K mutation are primarily associated with deficiencies in the erythroid lineage but it is possible that deficiencies in the niche might have the potential to exacerbate the condition. The strategy we describe provides a powerful approach to assess the effects of other mutations in KLF1 as well as other factors associated with the EBI niche.
Preliminary evidence for developing safe and efficient fecal microbiota transplantation as potential treatment for aged related cognitive impairments
Authors: Chen Xiaoxia , Zhang Wanling , Lin Zhijun , Zheng Chunyan , Chen Shufang , Zhou Haihong , Liu Zhou
Published: April 2023

Background

Recent studies have reported that gut microbiota is closely associated with cognitive fuction. Fecal microbiota transplantation (FMT) may be a potential treatment for cognitive impairment, but its efficacy in patients with cognitive impairment is unknown.

Objectives

This study aimed to investigate the safety and efficacy of FMT for cognitive impairment treatment.

Methods

Five patients aged 54–80 years (three women) were enrolled in this single-arm clinical trial from July 2021 to May 2022. The Montreal Cognitive Assessment-B (MoCA-B), Activities of Daily Living (ADL), and the cognitive section of the Alzheimer’s Disease Assessment Scale (ADAS-Cog) were assessed at days 0, 30, 60, 90, and 180. Additionally, stool and serum samples were obtained twice before FMT was administered and six months after the treatment. The structure of fecal microbiota was analyzed by 16S RNA gene sequencing. Serum samples were analyzed for metabolomics and lipopolysaccharide (LPS)-binding proteins by liquid chromatography-mass spectrometry and enzyme-linked immunosorbent assay, respectively. Safety was assessed based on adverse events, vital signs, and laboratory parameters during FMT and the follow-up period.

Results

The MoCA, ADL, and ADAS-Cog scores of patients with mild cognitive impairment (patients C and E) after FMT were improved or maintained compared with those before transplantation. However, patients with severe cognitive impairment (patients A, B, and D) had no worsening of cognitive scores. Fecal microbiota analysis showed that FMT changed the structure of gut microbiota. The results of serum metabolomics analysis suggested that there were significant changes in the serum metabolomics of patients after FMT, with 7 up-regulated and 28 down-regulated metabolites. 3b,12a-dihydroxy-5a-cholanoic acid, 25-acetylvulgaroside, deoxycholic acid, 2(R)-hydroxydocosanoic acid, and P-anisic acid increased, while bilirubin and other metabolites decreased. KEFF pathway analysis indicated that the main metabolic pathways were bile secretion and choline metabolism in cancer. No adverse effects were reported throughout the study.

Conclusions

In this pilot study, FMT could maintain and improve cognitive function in mild cognitive impairment by changing gut microbiota structure and affecting serum metabolomics. Fecal bacteria capsules were safe. However, further studies are needed to evaluate the safety and efficacy of fecal microbiota transplantation. ClinicalTrials.gov Identifier: CHiCTR2100043548.
Synergistic effect and antibiofilm activity of the antimicrobial peptide K11 with conventional antibiotics against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae
Authors: Chatupheeraphat Chawalit , Peamchai Jiratchaya , Luk-in Sirirat , Eiamphungporn Warawan
Published: April 2023

Introduction

Infections caused by drug-resistant Klebsiella pneumoniae are now a serious problem for public health, associated with high morbidity and mortality due to limited treatment options. Therefore, new antibacterial agents or a combination of agents as the first line of treatment are urgently needed. K11 is a novel antimicrobial peptide (AMP) that has demonstrated in vitro antimicrobial activity against several types of bacteria. Additionally, K11 has previously shown no hemolytic activity. Herein, the antibacterial activity, the synergistic action of K11 in combination with different conventional antibiotics and the antibiofilm activity of K11 against multidrug-resistant (MDR) and extensively drug-resistant (XDR) K. pneumoniae were investigated. Meanwhile, the stability and ability to induce the bacterial resistance of K11 were also tested.

Methods

Fifteen clinical isolates of MDR/XDR K. pneumoniae were used in this study. The minimum inhibitory concentration (MIC) of K11 against these isolates was determined by the broth microdilution method. In vitro synergy between K11 and antibiotics was evaluated using the checkerboard methodology. The antibiofilm activity of K11 against K. pneumoniae strong biofilm producers were explored by the crystal violet staining. The stability in different environments and resistance induction of K11 were evaluated by MIC determination.

Results

The MIC values of K11 against MDR/XDR K. pneumoniae isolates were 8-512 μg/mL. Intriguingly, the synergistic effects were clearly observed for K11 in combination with chloramphenicol, meropenem, rifampicin, or ceftazidime, whereas no synergy was observed when K11 was combined with colistin. Besides, K11 effectively prevented biofilm formation against K. pneumoniae strong biofilm producers in a concentration-dependent manner starting at 0.25×MIC and exerted an enhancing effect when administered in combination with meropenem, chloramphenicol, or rifampicin. Additionally, K11 demonstrated high thermal and wide pH stability along with good stability in serum and physiological salts. Significantly, K. pneumoniae showed no induction of resistance even after prolonged exposure to a sub-inhibitory concentration of K11.

Conclusion

These findings indicate that K11 is a promising candidate with potent antibacterial and antibiofilm activities without inducing resistance and acts synergistically with conventional antibiotics against drug-resistant K. pneumoniae.
Toward resilient autonomous driving—An experience report on integrating resilience mechanisms into the Apollo autonomous driving software stack
Authors: Lucchetti Federico , Graczyk Rafal , Völp Marcus
Published: April 2023

Autonomous driver assistance systems (ADAS) have been progressively pushed to extremes. Today, increasingly sophisticated algorithms, such as deep neural networks, assume responsibility for critical driving functionality, including operating the vehicle at various levels of autonomy. Elaborate obstacle detection, classification, and prediction algorithms, mostly vision-based, trajectory planning, and smooth control algorithms, take over what humans learn until they are permitted to control vehicles and beyond. And even if humans remain in the loop (e.g., to intervene in case of error, as required by autonomy levels 3 and 4), it remains questionable whether distracted human drivers will react appropriately, given the high speed at which vehicles drive and the complex traffic situations they have to cope with. A further pitfall is trusting the whole autonomous driving stack not to fail due to accidental causes and to be robust against cyberattacks of increasing sophistication. In this experience report, we share our findings in retrofitting application-agnostic resilience mechanisms into an existing hardware-/software-stack for autonomous driving—Apollo—as well as where application knowledge helps improve existing resilience algorithms. Our goal is to ultimately decrease the vulnerability of autonomously driving vehicles to accidental faults and attacks, allowing them to absorb and tolerate both, as well as to come out of them at least as secure as before the attack has happened. We demonstrate replication and rejuvenation on the driving stack's Control module and indicate how this resilience can be extended both downwards to the hardware level, as well as upwards to the prediction and planning modules.