bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism of Depression through Brain Function Imaging of Depression Patients and Normal People
Authors: Tang Chaozhi , Zhang Yuling , Zhai Zihan , Zhu Xiaofeng , Wang Chaowei , Yang Ganggang
Published: January 2022

In recent years, functional magnetic resonance technology has discovered that abnormal connections in different brain regions of the brain may serve as the pathophysiological mechanism of mental illness. Exploring the mechanism of information flow and integration between different brain regions is of great significance for understanding the pathophysiological mechanism of mental illness. This article aims to analyze the mechanism of depression by comparing human brain images of normal people and patients with depression and conduct research. Fluoxetine, a selective 5-HT reuptake inhibitor (SSRI) widely used in clinical practice, can selectively inhibit 5-HT transporter and block the reuptake of 5-HT by the presynaptic membrane. The effect of 5-HT is prolonged and increased, thereby producing antidepressant effects. It has low affinity for adrenergic, histaminergic, and cholinergic receptors and has a weaker effect, resulting in fewer adverse reactions. This paper uses the comparative experiment method and the Welch method and uses the average shortest path length L to describe the average value of the shortest path length between two nodes in the network. Attention refers to the ability of a person’s mental activity to point and to concentrate on something. Sustained attention means that attention is kept on a certain cognitive object or activity for a certain period of time, which is also called the stability of attention. The research on attention of depression patients generally focuses on continuous attention, and the results obtained show inconsistencies. Most studies have shown that the sustained attention of the depression group is significantly worse than that of the healthy control group. An overview of magnetic resonance imaging technology and an analysis of depression based on resting state were carried out. The key brain areas of the sample core network were scanned, and the ALFF results were analyzed. The data showed that the severity of depression in the depression group was negatively correlated with the ReHo value in the posterior left cerebellum (

P
=
0.010

). The sense of despair was negatively correlated with the ReHo value in the posterior right cerebellum (

P
=
0.013

). The diurnal variation was negatively correlated with the ReHo value of the left ring (

P
=
0.014

). It was positively correlated with the ReHo value of the left ventricle (

P
=
0.048

). This experiment has better completed the research on the mechanism of depression by analyzing the functional images of patients with depression and normal human brain.
Application of Virtual Reality Technology in Film and Television Animation Based on Artificial Intelligence Background
Authors: Bao Yanrong
Published: January 2022

The application of artificial intelligence technology in the film and television field has profoundly changed the content and production methods of television programs and promoted the development and production of a new generation of artificial intelligence television. The popularization of artificial intelligence technology is conducive to improving the quality of television program content, innovating content categories, reducing television program production cost, and improving production efficiency. Due to the popularization and the use of virtual reality (VR) technology in scientific research and social life, the application of VR technology has been studied from the perspective of film and television animation (FTA) teaching, hoping to promote the development of FTA education. First, the existing dynamic environment modeling technology, real-time three-dimensional (3D) graphic generation technology, stereoscopic display, and sensor technology and other VR technologies are combined to carry out teaching design. In view of the current situation of the teaching process of FTA major, the research on these four aspects has been carried out. VR technology is used as an auxiliary teaching tool to complete the basic course teaching of FTA; the 3D animation course and VR technology are combined to improve the teaching effect of professional skill courses. Then, in the application effect, classroom satisfaction, comprehensive quality evaluation, and professional core curriculum effect are compared and analyzed. The results show that the students’ comprehensive quality evaluation in VR technology group is significantly improved, and the satisfaction of classroom atmosphere, teaching mode, and teaching facilities are 75%, 61%, and 81%, respectively. The students in this group can better integrate the new design method into the animation modeling and complete the course design task with high quality. Compared with the traditional teaching mode, the students’ satisfaction is higher and the harvest is greater. Therefore, the use of VR technology in FTA teaching can stimulate students’ interest in learning, improve learning efficiency, and promote the mastery of professional knowledge and skills. The application mode and effect analysis of the proposed VR technology provide a reference for the application of VR technology in FTA teaching.
Pore Structures of the Lower Permian Taiyuan Shale and Limestone in the Ordos Basin and the Significance to Unconventional Natural Gas Generation and Storage
Authors: Zhang L. , Zhao Q. , Wu C. , Qiu Z. , Zhang Q. , Wang Y. , Liu D. , Dong D. , Zhou S.
Published: January 2022

In the Ordos Basin, multiple sets of coal seams, organic-rich shale, and limestone are well developed in the Permian Taiyuan Formation, which are favorable targets for collaborative exploration of various types of unconventional natural gas resources, including coalbed methane, shale gas, and tight gas. In this study, core samples from the Permian Taiyuan Formation in the eastern margin of the Ordos Basin were used to carry out a series of testing and analysis, such as the organic matter characteristics, the mineral composition, and the pore development characteristics. In the shale of the Taiyuan Formation, the total organic carbon (TOC) content is relatively high, with an average of 5.38%. A thin layer of black shale is developed on the top of the Taiyuan Formation, which is relatively high in TOC content, with an average of 9.72%. The limestone in the Taiyuan Formation is also relatively high in organic matter abundance, with an average of 1.36%, reaching the lower limit of effective source rocks (>1%), being good source rocks. In the shale of the Taiyuan Formation, various types of pores are well developed, with relatively high overall pore volume and pore-specific surface area, averaging 0.028 ml/g and 13.28 m2/g, respectively. The pore types are mainly mineral intergranular pores and clay mineral interlayer fractures, while organic matter-hosted pores are poorly developed. The limestone of the Taiyuan Formation is relatively tight, with lower pore volume and pore-specific surface area than those of shale, averaging 0.0106 ml/g and 2.72 m2/g, respectively. There are mainly two types of pores, namely, organic matter-hosted pores and carbonate mineral dissolution pores, with a high surface pore rate. The organic matter in the limestone belongs to the oil-generation kerogen. During thermal evolution, the organic matter has gone through the oil-generation window, generating a large number of liquid hydrocarbons, which were cracked into a large number of gaseous hydrocarbons at the higher mature stage. As a result, a large number of organic matter-hosted pores were generated. The study results show that in the Ordos Basin, the shale and limestone of the Permian Taiyuan Formation have great potential in terms of unconventional natural gas resources, providing a good geological basis for the collaborative development of coal-bearing shale gas and tight limestone gas in the Taiyuan Formation.
The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study
Authors: Matsuoka-Uchiyama Natsumi , Uchida Haruhito A. , Okamoto Shugo , Onishi Yasuhiro , Katayama Katsuyoshi , Tsuchida-Nishiwaki Mariko , Takeuchi Hidemi , Takemoto Rika , Hada Yoshiko , Umebayashi Ryoko , Kurooka Naoko , Tsuji Kenji , Eguchi Jun , Nakajima Hirofumi , Shikata Kenichi , Wada Jun
Published: January 2022

Objective. We examined whether or not day-to-day variations in lipid profiles, especially triglyceride (TG) variability, were associated with the exacerbation of diabetic kidney disease. Methods. We conducted a retrospective and observational study. First, 527 patients with type 2 diabetes mellitus (DM) who had had their estimated glomerular filtration rate (eGFR) checked every 6 months since 2012 for over 5 years were registered. Variability in postprandial TG was determined using the standard deviation (SD), SD adjusted (Adj-SD) for the number of measurements, and maximum minus minimum difference (MMD) during the first three years of follow-up. The endpoint was a ≥40% decline from baseline in the eGFR, initiation of dialysis or death. Next, 181 patients who had no micro- or macroalbuminuria in February 2013 were selected from among the 527 patients for an analysis. The endpoint was the incidence of microalbuminuria, initiation of dialysis, or death. Results. Among the 527 participants, 110 reached a ≥40% decline from baseline in the eGFR or death. The renal survival was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test

p
=
0.0073

, 0.0059, and 0.0195, respectively). A lower SD, lower Adj-SD, and lower MMD were significantly associated with the renal survival in the adjusted model (hazard ratio, 1.62, 1.66, 1.59; 95% confidence intervals, 1.05-2.53, 1.08-2.58, 1.04-2.47, respectively). Next, among 181 participants, 108 developed microalbuminuria or death. The nonincidence of microalbuminuria was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test

p
=
0.0241

, 0.0352, and 0.0474, respectively). Conclusions. Postprandial TG variability is a novel risk factor for eGFR decline and the incidence of microalbuminuria in patients with type 2 DM.
Monitoring and Analysis of Physical Exercise Effects Based on Multisensor Information Fusion
Authors: Zhou Xinliang , Wen Shantian
Published: January 2022

In this paper, multiple sensors are used to track human physiological parameters during physical exercise, and data information fusion technology is used to extract useful information for monitoring and analyzing the effects of physical exercise. This paper explores the interaction and developmental dynamics of multisensor information fusion technology and physical exercise data monitoring based on the interrelationship and interpenetration between the two. The design ideas and principles that should be followed for the software designed in this study are discussed from the perspective of the portable design of measurement instruments and the perspective of multisensor information fusion, and then, the overall architecture and each functional module are studied to propose a scientific and reasonable design model. The general methodological model to be followed for the development of this resource is designed, and the basic development process of the model is explained and discussed, especially the requirement analysis and structural design, and how to build the development environment are explained in detail; secondly, based on the course unit development process in this model, we clarify the limitations of the system through meticulous analysis of the measurement results, which provides a solid foundation for the next step of system optimization. Finally, with a focus on future development, we elaborate on the potential possible role and development trend of multisensor information fusion in the future period. In this paper, we propose to apply the multisensor data fusion algorithm to the monitoring, analysis, and evaluation of the effect of physical exercise, by collecting multiple human physiological parameters during physical exercise through multiple sensors and performing data fusion processing on the collected physiological parameters to finally evaluate the effect of physical exercise.
Psychological Health Assessment Model of Enterprise Employees Based on DNN Technology
Authors: Li Xin
Published: January 2022

All enterprises gradually recognise the importance of employees’ healthy psychology to business activities in order to improve their own economic level and occupy a certain leading position in the economic market. The main factors affecting employees’ psychological health are used as input samples in this paper, and a network model of enterprise employees’ psychological health prediction based on DNN is developed. To form a specific set, the psychological health indicators are separated from the complex test items. The key influencing factors in psychological health assessment are chosen as input vectors, and the DNN algorithm’s output results are obtained, analysed, and compared. Following sample training, the artificial NN’s error between predicted and measured values is only 3.55 percent, achieving the desired effect. The DNN principle is used in this paper to create a mathematical prediction network model based on an analysis of psychological factors affecting employees in businesses. The calculation of the final result of the prediction system is simple and flexible when the parameters of the NN are changed, and the network model’s prediction efficiency and accuracy are greatly improved.
In Vitro Assessment of the Cercaricidal Activity of Sida acuta Burm. F. and Sida rhombifolia Linn. (Malvaceae) Hydroethanolic Extracts, Cytotoxicity, and Phytochemical Studies
Authors: Membe Femoe Ulrich , Kadji Fassi Joseph Bertin , Boukeng Jatsa Hermine , Tchoffo Yannick Leonel , Amvame Nna David Carel , Kamdoum Blaise Cédric , Njonte Wouamba Steven Collins , Toussie Tchegnitegni Billy , Tchaleu Ngadjui Bonaventure , Sewald Norbert , Ndjakou Lenta Bruno , Tchuem Tchuente Louis-Albert , Dimo Theophile
Published: January 2022

Despite the global efforts, schistosomiasis remains a public health problem in several tropical and subtropical countries. One of the major challenges in the fight against schistosomiasis is the interruption of the parasite life cycle. Here, we evaluated the anticercarial, cytotoxicity, and phytochemical profiles of Sida acuta (HESa) and Sida rhombifolia (HESr) hydroethanolic extracts (Malvaceae). Schistosoma mansoni cercaria was collected from fifteen Biomphalaria pfeifferi-infected snails. Twenty-five cercariae were incubated in duplicate with different concentrations (31.25–1,000 μg/mL) of HESa or HESr. The cercaria viability was monitored at 30 min time intervals for 150 min, and the concentration-response curve of each plant extract was used to determine their respective lethal concentration 50 (LC50). Additionally, the cytotoxicity profile of each plant extract was evaluated on the Hepa 1–6 cell line at a concentration range of 15.625–1,000 µg/mL using the WST-8 assay method and its inhibitory concentration 50 (IC50) was calculated. Moreover, phytochemical characterization of each plant extract was carried out by HPLC-MS. Both extracts exhibited cercaricidal activity in a time- and concentration-dependent manner. At 30 min time point, HESa (LC50 = 28.41 ± 3.5 µg/mL) was more effective than HESr (LC50 = 172.42 ± 26.16 µg/mL) in killing S. mansoni cercariae. Regarding the cytotoxicity effect of both extracts, the IC50 of HESa (IC50 = 109.67 µg/mL) was lower than that of HESr (IC50 = 888.79 µg/mL). The selectivity index was 3.86 and 5.15 for HESa and HESr, respectively. Fifteen compounds were identified from HESa and HESr after HPLC-MS analysis. N-Feruloyltyramine, a polyphenol, and thamnosmonin, a coumarin, were identified in both extracts. HESa and HESr displayed cercaricidal activity and were not toxic on Hepa 1–6 cell line. Based on the selectivity index of these extracts, S. rhombifolia extract could be more effective on S. mansoni cercariae than S. acuta extract. This study could provide baseline information for further investigations aiming to develop plant-based alternative drugs against S. mansoni.
Clinical Effectiveness and Safety of Chinese Herbal Medicine Compound Kushen Injection as an Add-On Treatment for Breast Cancer: A Systematic Review and Meta-Analysis
Authors: Lai Bao-Yong , Chu Ai-Jing , Yu Bo-Wen , Jia Li-Yan , Fan Ying-Yi , Liu Jian-Ping , Pei Xiao-Hua
Published: January 2022

Objective. To systematically evaluate the effect and safety of compound Kushen injection (CKI) as an add-on treatment on the treatment for breast cancer. Methods. We searched eight major electronic databases from their inception to November 1, 2021, for randomized clinical trials (RCTs) comparing CKI plus chemotherapy with chemotherapy alone. Primary outcomes included objective response rate (ORR) and disease control rate (DCR), health-related quality of life (HRQoL), progression-free survival (PFS), and overall survival (OS). Secondary outcomes included adverse drug reactions (ADRs) and tumor marker level. We used Cochrane’s RevMan 5.3 for data analysis. The GRADEpro was used to appraise the certainty of evidence. Trial sequential analysis (TSA) was applied to estimate the required sample size in a meta-analysis and test the robustness of the current results. Results. Thirty RCTs with 2556 participants were totally included. CKI plus chemotherapy showed significant effects in increasing ORR (RR 1.30, 95%CI [1.18, 1.43], I2 = 27%, n = 1694), increasing DCR (RR 1.21, 95%CI [1.15, 1.28], I2 = 16%, n = 1627), increasing HRQol as measured by Karnofsky Performance Scale (KPS) score improvement rate (RR 1.42, 95% CI [1.26, 1.61], I2 = 37%, n = 1172), increasing the PFS (MD 2.24 months, 95%CI [1.26, 3.22], n = 94) and the OS (MD 2.24 months, 95%CI [1.45, 3.43], n = 94), compared to chemotherapy alone. The results showed that CKI plus chemotherapy had a lower risk of ADRs than that of chemotherapy alone group. The certainty of evidence of the included trials was generally low to very low. TSA for ORR and KPS score improvement rate demonstrated that the current results reached a sufficient power regarding both numbers of trials and participants. Conclusions. Low certainty of evidence suggested that the combination of CKI and conventional chemotherapy appeared to improve ORR, DCR, and KPS score in breast cancer patients. Conclusions about PFS and OS could not be drawn due to lack of evidence. Additionally, CKI appeared to relieve the risk of ADRs in patients with breast cancer receiving chemotherapies. However, due to weak evidence, the findings should be further confirmed in large and rigorous trials.
Joint Optimization Decision of Online Retailers’ Pricing and Live‐Streaming Effort in the Postepidemic Era
Authors: Liu Jinrong , Xu Qi , Sun Zhongmiao
Published: January 2022

The isolation requirements of the coronavirus epidemic and the intuitive display advantages of live‐streaming have led to an increasing number of retailers shifting to social live‐streaming platforms and e‐commerce live‐streaming platforms to promote and sell their products in real time. However, the provision of live‐streaming services will also incur high live‐streaming effort costs. In this paper, we develop two decision models for retailers to sell goods through a single online shop and both online shop and live‐streaming room; we also present the optimal decisions of pricing and live‐streaming efforts. Furthermore, we identify the profitability conditions for retailers to determine when to provide live‐streaming services. In addition, we examine the impact of the provision of live‐streaming services on the optimal price and live‐streaming effort. We obtain three findings. First, there is a unique optimal decision on the price and live‐streaming effort under certain conditions. Second, when the effect coefficient of the live‐streaming room reaches a certain threshold, there are enough customers who enter the live‐streaming room to watch and buy and it is profitable for retailers to provide live‐streaming service. Finally, the optimal price and live‐streaming effort increase with the increase in average return loss, the effect coefficient of live‐streaming effort, and the extra return rate and decrease with the increase in the proportion of customers who choose to buy in the online shop and the price discount coefficient in the live‐streaming room.
Salvage Therapy in Early Relapse of T-Lymphoblastic Leukemia/Lymphoma Using Daratumumab/Nelarabine Combination: Two Consecutive Cases
Authors: Molle Ingolf , Petruskevicius Irma , Kamper Peter , d’Amore Francesco
Published: January 2022

Treatment of early relapses of T lymphoblastic leukemia/lymphoma is often unsuccessful. We tested an experimental regimen containing daratumumab and nelarabine in two young patients with early relapses of T lymphoblastic lymphoma and T-ALL, respectively. Both patients achieved a deep complete remission. Combining daratumumab with chemotherapy may have a role in relapsing T lymphoblastic leukemia/lymphoma.
Tumor MHC Class I Expression Associates with Intralesional IL2 Response in Melanoma
Authors: Pourmaleki Maryam , Jones Caitlin J. , Ariyan Charlotte E. , Zeng Zheng , Pirun Mono , Navarrete Daniel A. , Li Yanyun , Zhang Mianlei , Nandakumar Subhiksha , Campos Carl , Nadeem Saad , Klimstra David S. , Temple-Oberle Claire F. , Brenn Thomas , Lipson Evan J. , Schenk Kara M. , Stein Julie E. , Taube Janis M. , White Michael G. , Traweek Raymond , Wargo Jennifer A. , Kirkwood John M. , Gasmi Billel , Goff Stephanie L. , Corwin Alex D. , McDonough Elizabeth , Ginty Fiona , Callahan Margaret K. , Schietinger Andrea , Socci Nicholas D. , Mellinghoff Ingo K. , Hollmann Travis J.
Published: January 2022

Cancer immunotherapy can result in lasting tumor regression, but predictive biomarkers of treatment response remain ill-defined. Here, we performed single-cell proteomics, transcriptomics, and genomics on matched untreated and IL2 injected metastases from patients with melanoma. Lesions that completely regressed following intralesional IL2 harbored increased fractions and densities of nonproliferating CD8+ T cells lacking expression of PD-1, LAG-3, and TIM-3 (PD-1−LAG-3−TIM-3−). Untreated lesions from patients who subsequently responded with complete eradication of all tumor cells in all injected lesions (individuals referred to herein as “extreme responders”) were characterized by proliferating CD8+ T cells with an exhausted phenotype (PD-1+LAG-3+TIM-3+), stromal B-cell aggregates, and expression of IFNγ and IL2 response genes. Loss of membranous MHC class I expression in tumor cells of untreated lesions was associated with resistance to IL2 therapy. We validated this finding in an independent cohort of metastatic melanoma patients treated with intralesional or systemic IL2. Our study suggests that intact tumor-cell antigen presentation is required for melanoma response to IL2 and describes a multidimensional and spatial approach to develop immuno-oncology biomarker hypotheses using routinely collected clinical biospecimens.
Acute Kidney Injury at Hospital Admission for SARS-CoV-2 Infection as a Marker of Poor Prognosis: Clinical Implications for Triage Risk Stratification
Authors: Bravi Carlo Andrea , Cazzaniga Walter , Simonini Marco , Larcher Alessandro , Messaggio Elisabetta , Zagato Laura , Carenzi Cristina , Bertini Roberto , Briganti Alberto , Manunta Paolo , Vezzoli Giuseppe , Salonia Andrea , Lanzani Chiara , Capitanio Umberto , Zangrillo Alberto , Landoni Giovanni , Rovere-Querini Patrizia , Tresoldi Moreno , Montorsi Francesco , Ciceri Fabio
Published: January 2022

Background/Aims: The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a wide spectrum of effects, including acute kidney injury (AKI) in up to 40% of hospitalized patients. Given the established relationship between AKI and poor prognosis, whether AKI might be a prognostic indicator for patients admitted to the hospital for SARS-CoV-2 infection would allow for a straightforward risk stratification of these patients. Methods: We analyzed data of 623 patients admitted to San Raffaele Hospital (Milan, IT) between February 25 and April 19, 2020, for laboratory-confirmed SARS-CoV-2 infection. Incidence of AKI at hospital admission was calculated, with AKI defined according to the KDIGO criteria. Multivariable Cox regression models assessed the association between AKI and overall mortality and admission to the intensive care unit (ICU). Results: Overall, 108 (17%) patients had AKI at hospital admission for SARS-CoV-2 infection. After a median follow-up for survivors of 14 days (interquartile range: 8, 23), 123 patients died, while 84 patients were admitted to the ICU. After adjusting for confounders, patients who had AKI at hospital admission were at increased risk of overall mortality compared to those who did not have AKI (hazards ratio [HR]: 2.00; p = 0.0004), whereas we did not find evidence of an association between AKI and ICU admission (HR: 0.95; p = 0.9). Conclusions: These data suggest that AKI might be an indicator of poor prognosis for patients with SARS-CoV-2 infection, and as such, given its readily availability, it might be used to improve risk stratification at hospital admission.
Cavernous Gastric Hemangioma as an Unusual Cause of Upper Gastrointestinal Bleeding in a Young Woman
Authors: Sun Andrew , Sun Jeffrey , Sun Cheuk-Kay
Published: January 2022

Gastric hemangiomas (GHs) are extremely rare vascular lesions of mesodermal origin that may occur in isolation or in conjunction with underlying congenital pathology. Due to the scarcity of these tumors, there is no standardized diagnostic method; however, many have found the combination of endoscopic investigation and radiographic imaging to be most effective, with the presence of phleboliths on computerized tomography as being pathognomonic for GHs. Surgical treatment for symptomatic lesions is curative with no reports of recurrence. We describe a 21-year-old woman who presented with epigastric pain and one episode of 250 mL hematemesis earlier that morning. Under the impression of an upper gastrointestinal bleed due to peptic ulcer disease, esophagogastroduodenoscopy was performed which revealed a 5-cm blood clot-like mass similar in appearance to that of a II-b peptic ulcer, but the presence of a bridging fold led to the suspicion of a possible submucosal tumor. Dynamic computerized tomography scan showed similar findings, and the patient was referred for surgical intervention. Laparoscopic distal gastrectomy was performed with the final diagnosis of cavernous GH made via histological evaluation. The patient was discharged 9 days later with no complications. This case puts emphasis on the importance of considering cavernous GH as a potential cause of severe upper GI bleeding especially in those with atypical demographic profile and history.
Guidance on COVID-19 Vaccination in Hidradenitis Suppurativa Patients: A Modified Delphi Consensus of Experts
Authors: Rick Jonathan W. , De Devea R. , Shih Terri , Alavi Afsaneh , Kirby Joslyn S. , Naik Haley B. , Frew John W. , Sayed Christopher J. , Hsiao Jennifer L. , Shi Vivian Y.
Published: January 2022

Introduction: Hidradenitis suppurativa (HS) patients may be at increased risk of COVID-19 infection and complications from their medications and comorbidities. There is a lack of expert consensus on recommendations for the COVID-19 vaccine for HS patients. Herein, we aim to provide expert-driven consensus recommendations regarding COVID-19 vaccinations in HS patients. Methods: A modified Delphi consensus survey developed by a core committee of 7 dermatologist HS experts consisting of 4 demographic questions and 12 practice statements was distributed to the US HS Foundation-sponsored provider listserv. Participants were attending physician HS experts. Survey results were to be reviewed by the core group and revised and resubmitted until consensus (≥70% agreement) was achieved. Results: Among the 33 survey participants, there were 30 (87%) dermatologists, 1 general surgeon, 1 plastic surgeon, and 1 rheumatologist. Consensus for all 12 statements on vaccine counseling and HS treatment counseling was achieved after the first round. Discussion/Conclusion: For now, this consensus can serve as a resource for clinicians discussing COVID-19 vaccination with their HS patients. These recommendations will need to be updated as new evidence on COVID-19 emerges.
Exploring Indicators of Hepatotoxicity-Related Post-Marketing Regulatory Actions: A Retrospective Analysis of Drug Approval Data
Authors: Almomen Salwa M. , Almaghrabi Mona A. , Alhabardi Saja M. , Alrwisan Adel A.
Published: January 2022

Background: Hepatotoxicity is a major reason for medication withdrawal from the markets. Unfortunately, serious adverse hepatic effects can occur after marketing with limited indicators during clinical development. Therefore, finding possible predictors for hepatotoxicity might guide the monitoring program of various stakeholders such as drug regulatory authorities. Objective: To explore the potential of drugs, pre-approval regulatory factors as predictors for the occurrence of hepatotoxicity-related post-marketing regulatory actions. Pre-approval factors were specified as: (a) Hy’s Law hepatotoxicity grade ≥3, (b) accelerated approval status, and (c) labeled hepatic adverse effects and regulatory actions at approval. Methods: Using publicly accessible FDA data, we examined clinical review documents for drugs approved in the USA during the period from 2011 to 2016 to evaluate their hepatic safety profile, identifying the 3 specified indicators for analysis. Predictors (Covariates): We assessed whether these medications meet: (a) Hy’s Law hepatotoxicity grade ≥3, (b) accelerated approval status, and (c) labeled hepatic adverse effects and regulatory actions at approval. Outcome (Dependent Variable): Post-marketing regulatory action related to hepatotoxicity including products withdrawal and updates to either warning, precaution or adverse effects sections. Statistical Analysis: Drugs that were approved between 2011 and 2016 were included in the analysis with follow-up time from the date of approval until end of December 2019 or the date of first post-marketing regulatory action related to hepatotoxicity, whichever occurred first. The hazard ratio (HR) was estimated using Cox-regression analysis. Results: A total of 192 medications were included in the study. We classified 48 drugs with grade ≥3 hepatotoxicity, 43 with accelerated approval status, and 74 with labeled information about hepatotoxicity prior to marketing. The adjusted HRs for post-marketing regulatory action for products with grade ≥3 hepatotoxicity was 0.61 (95% confidence interval [CI], 0.17–2.23), 0.92 (95% CI, 0.29–2.93) for drug approved via accelerated approval program, and 0.91 (95% CI, 0.33–2.56) for drugs with labeled hepatotoxicity information at approval time. Conclusion: Hy’s Law with hepatotoxicity grade ≥3, accelerated approval, and label information on hepatotoxicity were not identified as predictors for post-marketing additional regulatory actions concerning liver adverse effects. However, the evidence is inconclusive due to small sample size and potential channeling bias.
Rapid Prototypable Biomimetic Peristalsis Bioreactor Capable of Concurrent Shear and Multi-Axial Strain
Authors: Clevenger Abigail J. , Crawford Logan Z. , Noltensmeyer Dillon , Babaei Hamed , Mabbott Samuel B. , Avazmohammadi Reza , Raghavan Shreya
Published: January 2022

Peristalsis is a nuanced mechanical stimulus comprised of multi-axial strain (radial and axial strain) and shear stress. Forces associated with peristalsis regulate diverse biological functions including digestion, reproductive function, and urine dynamics. Given the central role peristalsis plays in physiology and pathophysiology, we were motivated to design a bioreactor capable of holistically mimicking peristalsis. We engineered a novel rotating screw-drive based design combined with a peristaltic pump, in order to deliver multi-axial strain and concurrent shear stress to a biocompatible polydimethylsiloxane (PDMS) membrane “wall.” Radial indentation and rotation of the screw drive against the wall demonstrated multi-axial strain evaluated via finite element modeling. Experimental measurements of strain using piezoelectric strain resistors were in close alignment with model-predicted values (15.9 ± 4.2% vs. 15.2% predicted). Modeling of shear stress on the “wall” indicated a uniform velocity profile and a moderate shear stress of 0.4 Pa. Human mesenchymal stem cells (hMSCs) seeded on the PDMS “wall” and stimulated with peristalsis demonstrated dramatic changes in actin filament alignment, proliferation, and nuclear morphology compared to static controls, perfusion, or strain, indicating that hMSCs sensed and responded to peristalsis uniquely. Lastly, significant differences were observed in gene expression patterns of calponin, caldesmon, smooth muscle actin, and transgelin, corroborating the propensity of hMSCs toward myogenic differentiation in response to peristalsis. Collectively, our data suggest that the peristalsis bioreactor is capable of generating concurrent multi-axial strain and shear stress on a “wall.” hMSCs experience peristalsis differently than perfusion or strain, resulting in changes in proliferation, actin fiber organization, smooth muscle actin expression, and genetic markers of differentiation. The peristalsis bioreactor device has broad utility in the study of development and disease in several organ systems.
Controlling Morphology and Functions of Cardiac Organoids by Two-Dimensional Geometrical Templates
Authors: Hoang Plansky , Sun Shiyang , Tarris Bearett A. , Ma Zhen
Published: January 2022

Traditionally, tissue-specific organoids are generated as 3D aggregates of stem cells embedded in Matrigel or hydrogels, and the aggregates eventually end up a spherical shape and suspended in the matrix. Lack of geometrical control of organoid formation makes these spherical organoids limited for modeling the tissues with complex shapes. To address this challenge, we developed a new method to generate 3D spatial-organized cardiac organoids from 2D micropatterned human induced pluripotent stem cell (hiPSC) colonies, instead of directly from 3D stem cell aggregates. This new approach opens the possibility to create cardiac organoids that are templated by 2D non-spherical geometries, which potentially provides us a deeper understanding of biophysical controls on developmental organogenesis. Here, we designed 2D geometrical templates with quadrilateral shapes and pentagram shapes that had same total area but different geometrical shapes. Using this templated substrate, we grew cardiac organoids from hiPSCs and collected a series of parameters to characterize morphological and functional properties of the cardiac organoids. In quadrilateral templates, we found that increasing the aspect ratio impaired cardiac tissue 3D self-assembly, but the elongated geometry improved the cardiac contractile functions. However, in pentagram templates, cardiac organoid structure and function were optimized with a specific geometry of an ideal star shape. This study will shed a light on “organogenesis-by-design” by increasing the intricacy of starting templates from external geometrical cues to improve the organoid morphogenesis and functionality.
Maria Madalena no Cristianismo Primitivo
Authors: Santos Ana Pinheiro dos
Published: January 2022

Seguindo a proposta do grupo de pesquisa “Expressões religiosas minoritárias do cristianismo da Galiléia e Egito” do Prof. Dr. Paulo Roberto Garcia, esta pesquisa contextualizou a vida mulher no mundo greco-romano e palestinense. Para então falar especificamente do papel de Maria Madalena no cristianismo primitivo utilizando os escritos gnósticos de Nag Hammadi e o Evangelho de Maria Madalena
Algumas reflexões sobre direitos humanos e instituição total em produções midiáticas
Authors: Amaral Dayse Kohmoto do
Published: January 2022

Neste ensaio procuramos refletir sobre direitos humanos e instituição total em sua relação com as mídias. Para isso, à luz da Declaração Universal dos Direitos Humanos (1948), focalizamos histórias de vida de alguns personagens que fizeram parte da história nacional por meio do documentário Vlado – 30 anos depois, dirigido por João Batista Andrade, e do artigo “Duas memórias de presos políticos: Argentina e Brasil (anos 1970)”, escrito pelo Prof. Dr. Afrânio Mendes Catani. Além disso, buscamos articular outras produções midiáticas à categoria de instituição total. Por fim, entendemos que a história da sociedade e as histórias de vidas dos diferentes sujeitos sociais, veiculadas – ou não – pela mídia, relacionam-se e transformam o mundo social do qual fazemos parte
A Publicidade contemporânea e as Teorias de Comunicação de Massa
Authors: Kawano Diogo Rógora , Trindade Eneus
Published: January 2022

A partir de leituras de obras clássicas sobre teorias da comunicação, dadas em Wolf(2005) e em Mattelart e Mattelart(2000), busca-se neste trabalho, apontar as principais reflexões teóricas da comunicação que contribuíram, e ainda contribuem, para a compreensão dos processos de comunicação da publicidade e propaganda, de modo a observar tanto as linhas teóricas mais utilizadas na esfera da publicidade, como também abrindo a reflexão para outras teorias e hipóteses menos trabalhadas nos estudos midiáticos da Propaganda
“O eyes”: Social and Cultural analysis of American society through The Oprah Winfrey Show
Authors: Costa Juliana Meres , Colbachini Marina Lee , Sato Sindy Mary García-Blásquez
Published: January 2022

O objetivo do presente artigo é a análise de aspectos da vida social e cultural norte-americana através de questões mostradas no The Oprah Winfrey Show, um popular e influente programa televisivo produzido e exibido no país. Para tanto, selecionamos algumas características do programa em questão, que se destacaram como sendo importantes para o entendimento das contradições presentes na cultura capitalista, e as analisamos. Pudemos constatar que os temas apresentados no programa refletem não apenas as contradições presentes na sociedade norte-americana, mas também as existentes na base econômica dessa sociedade; e que o programa, não apenas em seus temas, mas também em seu formato, representa um significante retrato da sociedade em questão
Clodovil Hernandes: a política entre o grotesco e o espetáculo na mídia brasileira
Authors: Kohn Karen , Casali Caroline
Published: January 2022

Este artigo traz como questão central a análise do tratamento midiático sobre Clodovil Hernandes, no período pós-eleições 2006. Nas reflexões aqui empreendidas acerca da relação entre comunicação e política, resgatam-se os conceitos de comunicação do grotesco, de Muniz Sodré; de midiatização, de Eliseo Verón; e de sociedade do espetáculo, de Guy Debord. Considera-se, como resultado das reflexões realizadas, que a mídia tem pré-julgado e legitimado a imagem de Clodovil como um Deputado debochado, despreparado e politicamente ignorante. Além disso, para além do tratamento midiático, o fenômeno de votos alcançados por Clodovil evidencia a valorização excessiva do grotesco e do espetáculo em nossa sociedade
Questão de gênero e raça: o desempenho escolar de meninos negros
Authors: Rezende Andréia Botelho de
Published: January 2022

A pesquisa aqui descrita abrangeu entrevistas com uma professora e quatro meninos negros de uma segunda série em uma escola pública na cidade de São Paulo. Os meninos negros entrevistados apresentavam um desempenho escolar igualmente insatisfatório. Apesar disso, foi possível perceber que eles desenvolviam diferentes estratégias para lidar com as exigências e regras escolares. Em alguns casos, eles assumiam uma atitude “antiescola” e eram protagonistas freqüentes de conflitos com colegas e professores. Em outros casos, no entanto, eles procuravam meios alternativos para serem reconhecidos e elogiados, por exemplo, sendo prestativos e solícitos. A partir destes resultados, concluímos pela heterogeneidade do grupo de meninos negros em relação as suas posturas e atitudes frente às dificuldades de aprendizagem
Rádios comunitárias: uma reflexão a partir do programa Estação Notícia da rádio Caraí FM de Santa Maria
Authors: Sanchotene Carlos Renan Samuel
Published: January 2022

O presente artigo resulta de um trabalho desenvolvido pelo Núcleo de Rádio do Curso de Jornalismo do Centro Universitário Franciscano (Unifra). O objetivo principal é abordar problemas e notícias da comunidade, assuntos que não são veiculados na mídia em geral, valorizando a informação local. O estudo é baseado em alguns conceitos de comunidade e cidadania como pressupostos para dar subsídios à elaboração de um projeto comunitário pioneiro em uma rádio comunitária. Também buscou-se estudar e compreender o funcionamento de uma rádio comunitária, a partir da lei federal 9.612, de 1998, e regulamentada pelo Decreto 2.615, que estabelece a radiodifusão comunitária
A representação visual do Papa Bento XVI nas capas de revistas semanais
Authors: Anjos Edienari Oliveira dos
Published: January 2022

Utilizando-se de conceitos da Análise do Discurso e Polifonia, o presente artigo tem por finalidade analisar os discursos produzidos nas capas de revistas Veja, Istoé, Carta Capital e Época que trataram do personagem Papa Bento XVI entre os anos de Abril de 2005 e Maio de 2007. O principal objetivo deste trabalho é atentar aos discursos produzidos pela mídia impressa a partir da construção de ideologias presentes nas iconografias dos periódicos de capa
Ah! Se a minha roupa de baixo falasse: a censura abaixo da linha da cintura
Authors: Casadei Eliza Bachega
Published: January 2022

A partir dos vetos impostos pela censura paulista à peça de teatro de revista “Era Uma Vez”, de Mário Meira Guimarães e Marcos César Guimarães, pretendemos explorar os desenvolvimentos no estatuto simbólico sofridos por duas temáticas bastante cotidianas: a roupa íntima e a educação sexual. A partir desses deslocamentos procuraremos entender qual foi o sistema lógico e coerente de crenças que guiou a ação do censor nessa peça
Construindo cidadania: a comunicação comunitária como estratégia para mobilização pró-renda
Authors: Sanchotene Carlos Renan Samuel , Garcia Adriana Domingues , Eckhartt Dayane
Published: January 2022

Este artigo resulta de um projeto de extensão em comunicação comunitária realizado por três alunos do 5° semestre do Curso de Comunicação Social – Jornalismo, do Centro Universitário Franciscano - Unifra. O principal objetivo foi mobilizar mulheres em um projeto de geração de renda por meio da comunicação na comunidade da Vila Lorenzi, localizada na região sul de Santa Maria. O trabalho desenvolvido na Oficina de Retalhos consiste no aprendizado de técnicas artesanais, utilizando retalhos de tecidos para confecção de tapetes, almofadas, colchas, bolsas e customização de roupas. O produto final foi um vídeo-documentário que registra o trabalho de mobilização social realizado
A Censura contra a Paulistanidade: a atuação do Departamento de Diversões Públicas sobre a peça Este Ovo é um Galo
Authors: Casadei Eliza Bachega
Published: January 2022

A História constantemente serviu como um instrumento para legitimar situações presentes. Baseado, normalmente, mais em anacronismos do que em mentiras, como salienta Eric Hobsbawn, a apropriação da História para a legitimação de situações presentes é tanto mais perigosa porque passa a ser propagada em livros escolares e produtos culturais. É a partir dessa ótica que iremos analisar, no presente artigo, a intervenção da censura na peça Este Ovo é um Galo, de Lauro César Muniz, que passou pelo Departamento de Diversões Públicas do Estado de São Paulo, em 1959. Ao explorar as tradições simbólicas da Revolução de 1932, a peça se torna alvo da censura, em uma época em que o elogio à nacionalidade estava em voga. A censura posiciona-se, portanto, cortando os elementos que ressaltem a paulistanidade
Os processos de formação e de subjetivação docente na EJA em atuação na extensão universitária na UFMG
Authors: Frade Érica Paula , Eiterer Carmen Lucia
Published: January 2022

Neste artigo irei me dedicar a escrever sobre o espaço especifico de formação de professores e desenvolvimento de saberes docentes que se constitui no PROEF2 (Projeto de Ensino Fundamental de Jovens e Adultos, 2º segmento) do qual faço parte como educadora da área de história. O projeto é parte das atividades de extensão da Faculdade de Educação da Universidade Federal de Minas Gerais. Buscarei relatar, as experiências pedagógicas vividas neste espaço, como docente em formação supervisionada em serviço, para isto julgo necessário fazer uma breve explanação do projeto e ainda a respeito do sujeito especifico da EJA
Além das palavras: considerações histórico-metodológicas para a abordagem do filme Baraka
Authors: Gróf Gabriel Lohner
Published: January 2022

O uso de filmes como documento histórico remonta às reestruturações da ciência histórica durante a década de 70, acompanhando uma tendência geral dentro das ciências humanas. Encarado desde seus primórdios como construção, seu valor documental atinge prontamente às necessidades do historiador interessado não só no conteúdo veiculado pelo filme, mas também pela forma como são transmitidas as informações. Assim, inevitavelmente o pesquisador deve estar atento para as linguagens cinematográficas e seus significados dentro do gênero a que corresponde o filme. Para esta tarefa, a semiótica tem se mostrado indispensável, embora alguns historiadores prefiram se afastar dela, como Ferro por exemplo
Linguagem Escolar e a Construção da Identidade e Consciência Racial da Criança Negra na Educação Infantil
Authors: Teles Carolina de Paula
Published: January 2022

O presente texto aborda o papel da linguagem na constituição da identidade e consciência racial da criança negra. Constatou-se que o silêncio tem um papel relevante no que se que se refere à temática racial e educação, e nesse caso o silêncio tem resultados prejudiciais. O fato da temática não ser abordada nesse nível de ensino, dá a possibilidade de se reproduzir muitas concepções sobre a população negra. Assim, pudemos supor que mesmo que não se expresse, não significa que isso seja menos prejudicial à construção da identidade e consciência racial das crianças negras
Retextualização de Texto Oral
Authors: Santos Flávia Andréia dos , Cabrera Lúcia Gandarillas , Góes Vera Lúcia
Published: January 2022

Exporemos neste trabalho a prática da retextualização de um texto oral para um texto escrito, baseado no modelo proposto por Marcuschi. Nesse, encontramos a diferença entre a língua escrita e a língua falada. O trabalho baseia-se em um fragmento, de tipo Elocução Formal(EF), extraído do inquérito 375 do Projeto NURC/SP, que constitui parte de uma aula universitária sobre Análise Textual, cujo informante é do sexo feminino, com 34 anos na época (22/09/1976) e o inquérito de número 415. O processo de retextualização demonstra a insustentabilidade da visão dicotômica acerca da relação entre fala e escrita, uma vez que através dele podemos identificar as semelhanças e diferenças entre o texto falado e o escrito
Crash No Limite: uma análise da representação da violência e da discriminação racial nos Estados Unidos após os atentados de 11 de setembro com base em elementos da linguagem cinematográfica
Authors: Hoffmann Maria Luisa
Published: January 2022

A violência está presente diariamente nos meios de comunicação. O cinema, a “arte do real”, pela riqueza de seus meios de expressão, tem a capacidade de levar o espectador à reflexão. Este trabalho consiste na análise da representação da discriminação que gera a violência, através de códigos da estética e da linguagem cinematográfica a partir do filme “Crash - no limite”. Para a elaboração do trabalho foram utilizados, além da bibliografia sobre representação e cinema, livros da área de Antropologia e obras sobre os atentados de 11 de setembro. A partir de uma seleção de cenas do filme, foi aplicado o instrumento da análise semiótica buscando uma melhor compreensão da realidade e da situação de discriminação entre etnias nos Estados Unidos, após os atentados terroristas de 2001