bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengelolaan Arsip Digital Sebagai Sumber Informasi Bagi Remaja Masjid Baitul Halim Menggunakan Google Drive dan Dropbox
Authors: Hasan Muhamad , Purnama Jajang Jaya , Rahayu Sri , Mukhayaroh Anna
Published: March 2024

Archives are records or letters that are useful and have value, so it is important to store them properly. In this modern era, archives can be stored in digital form, namely in the form of images, sound, video, writing and so on. Digital archives can be managed through computer programs and stored on digital data storage media. With this transformation, it is certainly very easy for interested parties, such as institutions/organizations that own archives. With digital archive storage media connected to the internet, these archives can be accessed whenever and wherever they are. Nusa Mandiri University as one of the tertiary institutions in Indonesia which always carries out the tri dharma of higher education collaborates with the community in carrying out one of the tri dharma, namely community service. The civitas of Nusa Mandiri University held community service activities with Baitul Halim Mosque Youth (RBH), which is an organization formed by teenagers in the Tegal Parang area, South Jakarta. The community service this time raised the theme of Digital Archives Management as a Source of Information for Baitul Halim Mosque Youth Using Google Drive and Dropbox.
Pemberdayaan Ekonomi Masyarakat Melalui Pelatihan Make Up Di Jorong Ranah Sigading Nagari Laweh Selatan
Authors: Dewi Ika Parma , Rahma Yulia Azika , Asril Nurul Pratiwi Asril , Nopita Levi , Yeni Dhea Berliana Rahma , Nurcahyati  , Hutabarat Dini Hidayah
Published: March 2024

Cosmetology is facial art that aims to beautify the appearance of the face, with the right make-up technique it can cover some of the flaws on the face, make the face look fresh and bright. The rise of bridal models with make-up in modern clothes encourages housewives and young women in education. By doing this cosmetology training, unemployed housewives and young women can spend time attending cosmetology training courses. After they master make-up they can open their own make-up salon business. Makeup skills are also used as future capital to help restart the family economy. The method used in cosmetology training is to impart theoretical and practical principles. Planning begins with an explanation of material regarding make-up with make-up techniques and then continues with a make-up demo with the mothers. The goal is to tell the participants how to start from start to finish; what materials and tools to use, and so on.
CYTOKINE PROFILE RESPONSE IN PATIENTS WITH FRACTURES OF LONG BONES DURING COVID-19
Authors: Guriev S.O. , Tanasienko P.V. , Skobenko E.O.
Published: March 2024

Introduction: The immune system swiftly responds to the onslaught of trauma and the infectious agents it triggers. However, the mechanisms of action of the COVID-19 virus remain unidentified to date. Distinctive alterations that occur in the immune system of trauma victims with COVID-19, setting them apart from changes observed in other diseases. This underscores the specificity of traumatic disease within this patient with COVID-19.

The study aims to assess the response of humoral immunity markers in patients with fractures of long bones and COVID-19 and to explore their role in early diagnosing infectious complications in this particular group of patients.

Materials and methods: To accomplish the study objectives, we assembled a retrospective dataset comprising 289 cases of skeletal bone fractures treated at the Kyiv City Clinical Hospital of Emergency Medical Care from March, 2020 to February, 2021, meeting the inclusion criteria for the study. The entire dataset consisted of 289 cases of skeletal bone fractures, categorized into two groups: the main group and the control group.

 Results: On the first day of treatment, an increase in some pro-inflammatory cytokines (IL-6, IL-1β and IL-4) with a normal level of TNF-α, normal values of IFN-γ, IFN-α and a sharp decrease in the anti-inflammatory cytokine IL was observed among the patients of the main group -10. On the third day of the treatment, there was a significant increase in all pro-inflammatory cytokines (IL-6, IL-1β, IL-4 and TNF-α), both types of interferons, and an even sharper decrease in the anti-inflammatory cytokine IL-10. On the tenth day, the growth in the level of pro-inflammatory cytokines was noted, among which the level of TNF-α was the leader, a subnormal level of interferons and anti-inflammatory interleukin 10 was observed. Conclusions: The dynamics of pro-inflammatory cytokines in patients with long bone fractures against the background of COVID-19 tended to increase and had a maximum level on the third day of treatment. Anti-inflammatory cytokines demonstrate a tendency to depression and reache the reference value only on the 10th day of the study.
EFFECTS OF CHRONIC MATERNAL ALCOHOLIZATION ON THE CARDIOMYOCYTE CONTRACTILITY IN RAT OFFSPRINGS
Authors: Tverdokhlib I.V. , Marchenko D.G.
Published: March 2024

The effects of intrauterine alcohol exposure on heart development, specifically the contractile apparatus and myofibril distribution within cardiomyocytes, remain controversial. Aim: This study investigates the postnatal dynamics of myofibril ultrastructure in rat ventricular cardiomyocytes following chronic maternal alcohol exposure. Methods: We analyzed cardiac tissue from offspring of chronically alcoholized rats at various postnatal stages using transmission electron microscopy. Quantitative parameters of cardiomyocyte myofibrils in different ventricular myocardial zones were assessed. Results: Chronic maternal alcohol exposure appeared to inhibit sarcomerogenesis and reduced overall myofibril content in the hearts of newborn offspring. Furthermore, we observed increased myofibril surface area and disrupted spatial orientation in subendocardial left ventricular cardiomyocytes and intramural zones of both ventricles. Even in mature offspring, the myocardial contractile apparatus remained irreversibly damaged, exhibiting reduced myofibril density, increased surface area, and disrupted orientation.
MICROBIAL AIR POLLUTION IN POLTAVA
Authors: Faustova M.O. , Loban G.A. , Benedis V.G. , Faustov Ya.Yu.
Published: March 2024

Regular monitoring of air quality indicators, including microbial composition, is crucial for public health and should be a cornerstone of national healthcare policy. However, existing scientific literature lacks comprehensive data on microbial air pollution in Ukraine, particularly in Poltava and its surrounding areas. This study aims to assess the level of microbial air pollution across various districts within Poltava city.

Materials and methods. The Koch sedimentation method was used to assess the level of microbial air pollution in the districts of Poltava. For this purpose, atmospheric air sampling was taken in park zones of various districts in the city of Poltava during October 2023. For comparison, air samples were taken in deciduous and coniferous forests of villages adjacent to the city. According to the results of cultivation, the total microbial count (TCM) of the air in 1 m3 of each sample was calculated separately.

Statistical analysis of the obtained results was carried out using the standard Microsoft Excel 2019 and GraphPad Prism Software 10.1.0 software packages. (US, 2023).

Results. The study has revealed the greatest microbial pollution of atmospheric air was found in Pavlenkivskyi Park (Kyiv District, Poltava City). The air quality index of atmospheric air in Corpusnyi Park turned out to be 4 times lower, compared to the air index of the Kyiv district. During the cultivation of atmospheric air samples taken in the Voiniv-Afghantsiv park (Shevchenkivskyi district of the city), the TCM was determined to be 8.2 times lower than that of the Pavlenkivskyi park. Interestingly, the "Peremoha" park (Shevchenkivskyi district) exhibited the lowest levels of microbial contamination. Overall, the Podilskyi district demonstrated favorable air quality indicators, surpassed only by the "Peremoha" park. However, it's important to note the presence of hemolytic streptococci in this district, which poses a potential health risk.

Conclusion. The highest level of microbial air pollution has been found in the Kyiv district of Poltava, the lowest level is within the boundaries of the Shevchenkivskyi district on the territory of the "Peremoha" park. Microbiological air quality in Poltava's park areas exhibits an inverse relationship with proximity to the city's central roads.
CHRONIC EFFECT OF CADMIUM AND COPPER EXPOSURE ON THE HISTOLOGICAL STRUCTURE OF THE SMALL INTESTINE IN RAT EMBRYOS
Authors: Shatorna V.F. , Tymchuk K.M.
Published: March 2024

The search for bioantagonistic elements that mitigate cadmium toxicity and accumulation in the body is a pressing area of research. In this context, investigating the potential of trace element succinates holds promise, given their increasing application in medicine, biological experimentation, and pharmaceutical development.

This study aimed to evaluate the effects of chronic, isolated intragastric administration of cadmium chloride, and its combined administration with copper succinate, on the small intestine morphogenesis in developing rat embryos. Pregnant rats were exposed daily throughout pregnancy by oral gavage with solutions containing the respective agents at a dose of 2.0 mg/kg. Chronic daily exposure of pregnant rats to cadmium chloride via gavage resulted in structural alterations in the small intestine of embryos, evident as early as day 13 and becoming more pronounced by day 19. Compared to controls, cadmium exposure led to a thinner small intestine wall and a larger villus diameter in the intestinal mucosa. Notably, mucosal crypts were absent in the cadmium-exposed group at both time points. Conversely, the combined administration of cadmium chloride with copper succinate significantly restored most of the investigated histological parameters in the small intestine of embryos at both study days. Thus, the analysis of the obtained data has proven the effect of the isolated introduction of cadmium chloride leads to a reliable thickening of the villi of the small intestine and thinning of the mucosal walls in comparison to the control, and with the combined introduction of cadmium chloride with copper succinates, the indicators of the thickness of the mucous layer of the wall of the small intestine of the embryos had a tendency recovery to control group data. The obtained data allow us to consider copper succinate as a bioantagonist of cadmium chloride when administered intragastrically in the indicated doses in an experiment on rats.
REFINING METHODOLOGICAL APPROACHES TO ENHANCE TEACHING QUALITY AT THE DEPARTMENT OF INFECTIOUS DISEASES WITH EPIDEMIOLOGY
Authors: Poltorapavlov V.A. , Koval T.I. , Pryimenko N.O. , Marchenko O.G. , Vatsenko A.I.
Published: March 2024

Reforming Ukrainian higher medical education is imperative, not only to address issues related to the recognition of Ukrainian diplomas abroad and to enhance the competitiveness of Ukrainian medical institutions and their graduates on the European and global job markets, but also to elevate the efficiency and quality of education. Furthermore, the recent full-scale invasion has resulted in the loss of a significant potential in medical universities across the southeastern region of Ukraine.

Amidst the ongoing reform of the Ukrainian higher education system, all institutions are transitioning towards a competency-based approach. This approach aims to cultivate and foster specific types and subtypes of competencies in students by ensuring comprehensive assimilation of essential knowledge and practical methodologies.

The training of highly skilled medical professionals encompasses multidisciplinary education, extending beyond therapy to encompass knowledge spanning over two dozen specialties. Of utmost importance is the ability to diagnose and treat patients with acute and chronic therapeutic and surgical conditions, as well as to provide urgent medical assistance.

The epidemiological landscape concerning numerous infectious diseases in various countries remains volatile. Incidences of viral hepatitis, tuberculosis, influenza, SARS, AIDS, Lyme borreliosis, among others, continue to rise in Ukraine and neighboring regions. A completely new challenge for the world community is the outbreak of Ebola fever in West Africa, monkeypox and its spread around the world. The appearance of pathogens of infectious diseases resistant to previously developed effective drugs is a cause for concern. Nowadays, the global crisis precipitated by the novel coronavirus, SARS-CoV-2, underscores the urgency for education on emerging and re-emerging infections.

Given these challenges, the qualification level of future specialists in infectious diseases and epidemiology assumes paramount importance. These professionals must be equipped to organize and deliver medical care under adverse conditions such as war, pandemics, shortages of medical personnel and medications, and a dearth of theoretical and practical knowledge, especially in the face of new infections. To facilitate optimal learning amidst such crises, a phased approach is proposed that includes centralized distance education, methodological support, and practical skill acquisition. By implementing these measures, the assimilation of material and the quality of education can be enhanced for those seeking education during times of crisis.
EPIDEMIOLOGICAL CHARACTERISTICS OF MALIGNANT NEOPLASMS IN THE POPULATION OF THE MYKOLAIV REGION
Authors: Saveliev A.O. , Ziuzin V.O.
Published: March 2024

In order to study the epidemiological features of malignant neoplasms, methods of the statistical analysis were applied to assess the spread of malignant neoplasms in the population of the Mykolaiv region. This is a description of the regions characterized by statistically significant differences in the incidence of malignant neoplasms. An in-depth analysis of factors that potentially influence the development of cancer in areas with an increased risk of the occurrence and development of malignant tumors was conducted. For the epidemiological characteristics of malignant neoplasms in the population of the Mykolaiv region, the indicators of the National Cancer Registry, the Mykolaiv Regional Cancer Registry, and the statistics department of the Mykolaiv Regional Oncology Dispensary for the period from 2019 to 2021 were analyzed. Regional features of the development of malignant neoplasms in the population of the Mykolaiv region were revealed based on the analysis of statistical data on the primary detection of cancer in 19 regions, 3 cities and the regional center - Mykolaiv for 2019-2021. The improved method of assessing the medical and ecological situation at different territorial levels was based on a combination of traditional methods of research on cancer incidence and the use of information technologies. Correlation, factor and cluster analysis methods were used to assess the impact of individual environmental factors on the incidence of malignant neoplasms. Territorial regularities of the studied territories were investigated with the help of statistical analysis. Territorial statistics made it possible to analyze trends in the spread of disease, to identify cause-and-effect relationships between environmental factors and health indicators.
INDICATORS OF THE QUALITATIVE AND QUANTITATIVE COMPOSITION OF THE GUT COMMENSAL MICROBIOTA AS BIOMARKERS OF HOMEOSTASIS (Part 1)
Authors: Ananieva M.M. , Loban G.A. , Faustova M.O. , Chumak Y.V. , Losev S.M.
Published: March 2024

In recent years, practical medicine has faced a surge of information highlighting the emergence of new microbes in the human body's microbiota, leading to challenges in interpreting laboratory test results. This study aims to equip medical professionals, including doctors of various specialties, medical students, and interns, with a comprehensive understanding of the current knowledge on the human gastrointestinal microbial profile. Our analysis included 53 articles from international literature sources indexed in PubMed, Scopus, and Google Scholar databases. These articles were identified through an electronic search. The composition of the human microbiome is shaped by alterations in environmental conditions, living environments, diet, climate, genetics, and various other factors. Following birth, the pivotal role in microbiome formation involves the vertical, horizontal, and mixed transfer of microorganisms. Navigating the diversity of resident microbiota can be challenging, leading scientists to suggest biomarkers such as diversity indices, enterotypes, and established ratios at typical taxonomic levels (genus, species) for convenience. In clinical practice, these indicators serve as indirect markers of microflora properties that model health or disease. To understand the distribution of species within types, ecologists introduced concepts like α-, β-, and γ-diversity, grounded in different mathematical models. These indicators are also employed to assess the human body microbiota. The division into enterotypes was proposed by scientists on the basis that the phylogenetic (species) composition of each category determines its own functional feature, which is likely to be related to long-term eating habits. Conclusion. Scientists endeavor to assess the intricate microbiome system and its substantial impact on the human body, as well as the adverse effects of dysbiosis, employing mathematical models applied in microbiology.
MODERN VIEW ON ISSUES OF DIAGNOSING GINGIVAL RECESSION
Authors: Ivanytska O.S. , Lokes K.P. , Ivanytskyi I.O. , Bukhanchenko O.P.
Published: March 2024

Background. Given that the exposure of the tooth root is not only an aesthetic concern but also leads to dental hypersensitivity, cervical caries, non-carious lesions, and even tooth loss, understanding the causes and characteristics of gum recession, along with its timely detection, is crucial and relevant. The aim of this study is to analyze and consolidate scientific research dedicated to the investigation of factors influencing the development of gum recession, its diagnosis, and the clinical features. This understanding is essential for addressing the challenge dealing with the treatment of this condition. A comprehensive review of scientific publications addressing the specified topics was conducted using library sources and search systems, including PubMed, Web of Science, OUCI (Open Ukrainian Citation Index), and Index Copernicus. The prevalence of gingival recession varies from 9.7% in adolescents to nearly 100% in adults. Most investigators identified a higher number of recession areas on both the upper and lower jaws around the central and lateral incisors, as well as the right first molar. However, conflicting findings exist, with some researchers suggesting that gum recession occurs most frequently in the premolars and canines area. Nevertheless, there is a unanimous agreement among researchers that this disease is polyetiological. Authors assess the significance of different factors provoking recession in varying ways. Moreover, under specific conditions, several factors may combine, with one of them dominating. Despite numerous classification attempts by specialists, efforts to propose a classification that accurately reflects the characteristic features of this pathology, the severity of manifestations, and the prognosis of its treatment are still remaining pressing issues. Thus, among the factors that provoke the development of apical migration of the gingival margin, the leading role is played by the thin biotype of the gums and the peculiarities of the anatomical and morphological structure of the periodontal tissues, inflammatory diseases in the oral cavity, incorrect implementation of hygienic and preventive measures, orthopedic and orthodontic devices that lead to mechanical injury. Despite the large number of existing classifications of gum recession, none of them can fully satisfy dentists, as they are not able to objectively determine all the clinical manifestations of the disease, establish a connection with its etiology, and predict the course.
ROLE OF LABORATORY DIAGNOSTICS IN THE DENTAL PRACTICE
Authors: Boychenko О.M. , Moshel T.M.
Published: March 2024

Laboratory methods play a crucial role in dental practice, as the state of a patient's oral cavity frequently mirrors disruptions in metabolic processes within the body, and can also provide insights into potential pathology affecting individual organs and systems.

The aim of this study is to assess the efficacy of employing laboratory methods in patients with periodontal tissue diseases.

We conducted examinations on 35 patients diagnosed with chronic generalized periodontitis of degrees II and III, along with 15 patients diagnosed with chronic catarrhal gingivitis. Additionally, a control group comprising 15 patients diagnosed solely through clinical examination methods with generalized periodontitis was included in the study.

All patients underwent a comprehensive evaluation, including general and biochemical blood tests. The investigation of periodontal pocket contents involved cytological and microbiological analyses, employing the method of successive serial rinses.

The patients diagnosed with generalized periodontitis have demonstrated a slight elevation in leukocyte count to 10-12*109/l upon the assessment of the general clinical blood test, indicating an exacerbation of the pathological process in periodontal tissues.

Furthermore, patients with generalized periodontitis have exhibited leukocyte migration in oral fluid exceeding 120, signifying disease exacerbation. Cytological examination of periodontal pocket contents revealed a notable presence of epithelial cells.

In the microbiocenoses of both gingival and periodontal pockets, representatives of aerobic and facultative anaerobic microorganisms were predominant. Among patients diagnosed with catarrhal gingivitis, these microorganisms constituted 74.25% of the microbiota, while in those with generalized periodontitis, they accounted for 62.70%. During periods of exacerbated periodontitis, there was an increase in the proportion of anaerobes within the microflora of periodontal pockets, rising from 23.15% to 29.40%.

Research results have shown that patients with inflammatory and inflammatory-dystrophic periodontal diseases experience dysbiosis of gingival and periodontal pockets, characterized by a decrease in the antagonism of symbiont bacteria to pathogenic and potentially pathogenic microorganisms. The correct interpretation of laboratory studies carried out over time has not only diagnostic and prognostic significance, but is decisive in the choice of adequate treatment.
ACTIVATION OF THE IMMUNE-INFLAMMATORY RESPONSE AMONG PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA ASSOCIATED WITH CORONAVIRUS INFECTION
Authors: Avgaitis S.S. , Sid E.V.
Published: March 2024

The aim of the study is to determine the levels of markers of the immune-inflammatory response in patients with community-acquired pneumonia associated with coronavirus infection. Materials and methods. An open, prospective, observational study was conducted to achieve the goal and address the specified issues. From January, 2021 to February, 2022, 256 patients aged 40 to 65 years with community-acquired pneumonia were examined at the outpatient clinic of the Kherson City Clinical Hospital named after A. Tropin and O. Tropin. Among them, 177 patients had community-aquired pneumonia associated with SARS-CoV-2, and 79 were tested negative for coronavirus infection. Additionally, 35 healthy volunteers were examined on an outpatient basis. The assessment of interleukin-6, interleukin-10, and hsCRP was performed in blood plasma using enzyme-linked immunosorbent assay with standard kits: "HF CRP-ELISA-Best," "IL-6-ELISA-Best," "IL-10-ELISA-Best," following the provided instructions. Results. The level of high-sensitivity C-reactive protein between the groups of patients was significantly higher by 27.5% in the group of patients with community-acquired pneumonia and COVID-19 than in patients with community-acquired pneumonia without COVID-19. Interleukin-6 was the highest in the group of patients with community-acquired pneumonia and COVID and was significantly higher by 9.5% compared with the group of patients with community-acquired pneumonia without COVID and 3.8 times higher compared with the value in healthy volunteers. There was no significant difference in interleukin-10 levels between the group of patients with community-acquired pneumonia with COVID-19 and the group of patients with community-acquired pneumonia without COVID. The level of this indicator in the group of practically healthy volunteers was significantly higher by 14.3% and 13.9% compared to the group of patients with community-acquired pneumonia with COVID-19 and the group of patients with community-acquired pneumonia without COVID-19, respectively. Correlation analysis revealed the following relationships between the parameters: a direct relationship between interleukin-6 and high-sensitivity C-reactive protein (R = +0.43, p < 0.05) and a direct relationship between IL-6/IL-10 and high-sensitivity C-reactive protein (R = +0.35, p < 0.05). There was no significant correlation between interleukin-10 and high-sensitivity C-reactive protein levels. Conclusion. Assessment of proinflammatory cytokines can be used for predicting the severity of community-acquired pneumonia associated with coronavirus infection. The possible association between the level of proinflammatory cytokines and the severity of community-acquired pneumonia in the pre-hospital stage is important for assessing possible complications of the disease and developing a preventive action plan.
IMMUNOLOGICAL ANALYSIS OF ORAL FLUID IN PATIENTS WITH GENERALIZED PERIODONTITIS
Authors: Hlushchenko Т.А. , Batig V.М. , Kilmukhametova Yu.H. , Mytchenok О.V. , Vynogradova O.M.
Published: March 2024

The objective of this study is to conduct an immunological analysis of oral fluid, specifically focusing on determining the interleukin status among patients with generalized periodontitis and underlying metabolic syndrome. Materials and methods. For immunological studies, 3 groups were formed: main group, comparative and control groups. The main group included 30 individuals with generalized periodontitis and metabolic syndrome, the comparison group included 30 people with generalized periodontitis without somatic pathology; 20 healthy individuals with intact periodontium made up the control group. The content of pro-inflammatory cytokines IL-1β, IL-6, TNF-α and anti-inflammatory cytokines IL-4, TGF-β1 in the oral fluid of the subjects of the examination groups was determined by the method of solid-phase enzyme immunoassay using reagents of the company "Simko" (Ukraine).

Results. According to average values obtained, the highest levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) were found in individuals with periodontal pathology and metabolic syndrome. The value of the IL-1β content in the oral fluid of the main group was 1.1 times higher than the similar indicator of the comparison group, and 1.4 times higher than the indicator of the control group. The mean IL-6 content in the oral fluid of patients with metabolic syndrome was 1.3 times higher compared to individuals without the systemic disease. Interestingly, the disparity was more pronounced in healthy individuals, with IL-6 levels differing by 2 times.

Conclusion. Patients with metabolic syndrome and periodontal pathology have significant disturbances in cytokine regulation. Cytokines are key factors in the formation of a local inflammatory reaction, therefore, an increase in the concentration of pro-inflammatory IL-1 β can be considered an immune response to the inflammatory process in periodontal tissues.
TREATMENT EFFICACY FOR PERIODONTAL DISEASES IN MIDDLE-AGED INDIVIDUALS
Authors: Horban I. , Pasichnyk M. , Mykyyevych N. I. , Mykyyevych N. O.
Published: March 2024

The aim of the study is to evaluate and analyze the effectiveness of the proposed treatment mode for periodontal disease in middle-aged individuals.

 

Subjects and methods.The study comprised 62 individuals aged 46 to 60 years, including 32 men and 30 women with periodontal tissue diseases. Among them there were 24 patients diagnosed with chronic catarrhal gingivitis, and 38 patients with generalized periodontitis at the initial-I degree of development. The examinations were conducted at the Dental Medical Centre of Danylo Halytskyi Lviv National Medical University. The comparison group underwent standard treatment, while the intervention group was recommended to use the "Forteza" rinse solution and "Chlorophyllipt" tablets. Various indices were evaluated in all patients, including the Green-Vermillion index, periodontal index, and papillary bleeding index, both before treatment, immediately after treatment, and 6 months post-treatment. Results. The results obtained indicated a significant decrease (p > 0.05) in hygiene, bleeding, and periodontal indices among patients with chronic catarrhal gingivitis after treatment in both groups. However, it was noted that the baseline group exhibited superior outcomes compared to the comparison group. This difference persisted even 6 months after treatment. Similar results were obtained in patients with generalised periodontitis of the initial-I degree: the studied indices decreased in all patients immediately after treatment, but in the baseline group, the indices were significantly better immediately after treatment, and after six months.

Conclusions. The study confirmed significantly better treatment results in the baseline group. In particular, in patients with CСG, the PBI index and PI index values in six months after the treatment completion were significantly better in group I B in 1.6 times (p>0.05) than in group I A. A similar result was obtained in patients with initial, I degree, GP, namely, in group II B, the PBI was significantly better in 1.6 times (p>0.05) than in group II A, and the PI index was 1.4 times, respectively. Therefore, the prospect of further research is the implementation of an effective treatment mode for periodontal disease in the clinical practice for various age groups.
RESTORATION OF CORONAL PART IN CHEWING TEETH WITH SIGNIFICANT LOSS OF HARD TISSUES BY POST AND CORE CROWN
Authors: Yanishen I.V. , Krychka N.V. , Fedotova O.L. , Pohorila A.V. , Germanchuk S.M.
Published: March 2024

The purpose of this study was to improve the quality of orthopedic treatment of hard dental tissues of chewing teeth destroyed below the level of the gums by a post and core crown using ashless modeling plastics.

We examined 30 patients with severe destruction of the hard tissues of the crown portion of the teeth (IROPZ more than 80%) and concurrent periodontal diseases. A retrospective analysis revealed that teeth with deep subgingival defects restored by casts functioned as follows: for up to 1 year in 17 cases (14.2%), from 1 to 3 years in 36 cases (30.0%), from 3 to 5 years in 43 cases (35.8%), and for more than 5 years in 24 cases (20.0%).

The results of a comparative evaluation of the effectiveness of tooth restoration with subgingival defects using ashless acrylic plastic "Modeplast" as a modeling material demonstrated the highest quality of such inserts, with most observed cases showing no signs of secondary caries. Complications, such as the dislodgement of metal inserts, were noted in 6.7% of cases, violation of marginal fit in 4.5%, and partial decementation of the structure in 8.3%. Incorrect positioning and suboptimal pin dimensions of the post and core crown occurred with approximately equal frequency: 3.5% and 3.2%, respectively. Destruction of the hard tissues of the tooth and caries relapse during restoration with metal inserts were noted in 13.3% and 29.1% of cases, respectively. Typical complications leading to tooth extraction included tooth root fractures (13.3%).

The developed method of manufacturing post and core crowns using ashless acrylic plastic "Modeplast" at the modeling stage enables to gently remove tooth tissues and atraumatic fit of the post to the gums, prevents the accumulation of dental plaque and does not have a destructive effect on periodontal tissues.
MINERAL COMPOSITION OF MANDIBULAR BONE TISSUE IN SIMULATED PERIODONTITIS DURING METABOLIC ACIDOSIS
Authors: Kordiyak О.Y. , Moroz K.A. , Honta Z.M. , Nemesh O.M. , Shylivskyi I. V.
Published: March 2024

Destructive changes in the mandibular cancellous bone tissue determine the severity of periodontal diseases and affect their treatment outcomes. The imbalance between macro- and microelements leads to structural and functional changes in the spongy bone tissue of the lower jaw, and when being combined with the inflammatory process in the soft tissues of the periodontium leads to the tooth loss. Mineral elements deposited in the bones are included in the body buffer systems and are able to influence the metabolic processes of the macroorganism by mobilizing them into the bloodstream.

The aim of the study is to carry out a comparative analysis of mineral element concentrations in the bone tissue of the alveolar process of the lower jaw in rats with experimentally induced periodontitis under conditions of simulated metabolic disorders and following pharmacotherapeutic correction.

Materials and methods. The reseach was conducted on 80 white outbred sexually mature male rats aged 2-4 months and weighing 120-200 g. The animals were divided into 5 groups (16 in each): two control groups representing NC (negative control) and PC (conditionally positive control) and three experimental groups: I Group, II Group, III Group. The NC group consisted of animals kept on a standard vivarium diet throughout the experiment. The animals of PC, I – III Groups were exposed to peridontitis simulation: the rats received 0.04% solution of ammonium chloride (NH4Cl) per os within 30 days. Animals in group III (experimental periodontitis) received intramuscular injections of 5% meldonium dihydrate solution in a dose of 0.2 mg/kg of body weight. The rats in group IV (periodontitis treatment) received "Calcium glycerophosphate" (a first-generation calcium supplement) in a dose of 133 mg/kg. Group V (combination treatment) received both the meldonium dihydrate solution and calcium glycerophosphate in the same respective doses. Tissue levels of zinc, magnesium, strontium, calcium, sodium, potassium, phosphorus, and iron were measured using atomic absorption (zinc, magnesium), atomic emission (strontium, calcium, sodium, potassium), and photometric (phosphorus, iron) methods.

Results. The change in the amount of elements in the mandibular cancellous bone tissue reveals irregularity and different mechanisms over the course of the mineralization process, depending on the chosen means of correction. The findings obtained suggest that the corrective treatments (meldonium dihydrate, calcium glycerophosphate, or their combination) promoted gradual bone density improvement through the accumulation of studied elements in the rat mandible. This indicates potential reversibility of pathological changes at this experimental stage.

Conclusions. The cancellous part of the mandible in rats appears to be a dynamic system, responding actively to both detrimental factors and corrective interventions by altering the content and proportions of macro- and microelements.
РОЛЬ ЖАНРОВОЇ ФОРМИ У СУЧАСНОМУ ФОРТЕПІАННОМУ ВИКОНАВСЬКОМУ МИСТЕЦТВІ
Authors: Ivanovа Yulia Viktorivna
Published: March 2024

Мета роботи – проаналізувати виконавську діяльність вибраних видатних піаністів сучасності, знайти спільні та індивідуальні жанрово-композиційні риси їх виконавських стилів і репертуарних вподобань. Методологія дослідження передбачає поєднання аналітичного, стилістичного та порівняльного методів. Наукова новизна статті полягає в порівняльному аналізі показників творчої діяльності різних за віком видатних виконавців XXI століття (Марти Аргеріх, Григорія Соколова, Андраша Шиффа, Михайла Плетньова, Вадима Холоденка, Люка Дебарга, Юнчан Ліма), а також у визначенні домінуючих жанрових пріоритетів, які формують індивідуальний виконавський стиль. Також в роботі стисло зазначені жанрові номінації та інтерпретаційні стилі, які стають наявним важливим аспектом сучасного фортепіанного виконавства. Висновки. Семантична модель жанрової форми відіграє важливу роль у сучасному фортепіанному виконавському мистецтві. Жанрові номінації визначають стилістичні особливості, часові характеристики, структурні та комунікативні функції музичних творів, а також стають ґрунтовною основою для інтерпретації та виконання музики. Репертуарній вибір лише певною мірою залежить від індивідуальних жанрових пріоритетів виконавця. Основні жанрові номінації – поліфонічні, варіаційні, сюїті, сонаті форми, особливі форми фортепіанного концерту та фортепіанної транскрипції – репрезентовані у творчості всіх видатних представників сучасного фортепіанного виконавства, зумовлюють певну жанрово-композиційну спільність у виборі репертуару, що визначається, насамперед, великою цінністю певних музичних творів та прагненням до збереження високих канонів фортепіанної майстерності.
Paweł Śwital, Gwarancje prawne udziału mieszkańców we współzarządzaniu gminą, Instytut Naukowo-Wydawniczy „Spatium”, Radom 2019
Authors: Wojtyła Wojciech
Published: March 2024

Recenzja książki: Paweł Śwital, Gwarancje prawne udziału mieszkańców we współzarządzaniu gminą, Instytut Naukowo-Wydawniczy „Spatium”, Radom 2019, ss. 336.
Responses of red rice paddy under low nutrient supply in type B tidal swamp
Authors: Nisfuriah Laili , Asmawati Asmawati , Marlina Marlina , Rhompas Joni , Dali Dali , Kalasari Rastuti , Aryani Ida , Marlina Neni , Nasser Gamal Abdul , Rosmiah Rosmiah
Published: March 2024

Low soil fertility can constrain the paddy red rice yield. One of the efforts to increase paddy red rice production at the Tidal swamp area is using iron toxicity tolerant varieties. The objectives of this research were (i) to evaluate the agronomic responses of red paddy rice to low nutrient supply to determine the sensitive character and (ii) to identify the tolerant and nutrient-efficient variety under low nutrient supply in a tidal swamp area. The experiment was conducted at Tidal Swamp Area Type B, Telang Sari Village, Banyuasin District, South Sumatra Province. The experimental design was Split Plot with five replications. Nutrient supply was the main plot, and the Varieties (Inpara 7; Inpago 7, Aek Sibundong, and Telang Sari) were the subplot. The nutrient supply treatments were H1: standard fertilizer rate and H2: low nutrient supply, which is 30% of the standard rate. The results showed that Inpago 7 and Inpara 7 were potential varieties at low nutrient supply. The sensitive characteristics of the varieties evaluated were chlorophyll content, number of tillers, grain weight, and percentage of empty grain for growth and production characters.
Nutraceuticals with high antioxidant properties based on fruits and medicinal plants
Authors: Ziarati Parisa , Tajik Sepideh , Cruz-Rodriguez Luis
Published: March 2024

Recently, consuming natural food supplements derived from natural resources has become widespread in many developed societies due to the lack of side effects, low cost, and high antioxidant properties to prevent and treat many diseases. The research and formulation aimed to design a safe and effective medicinal and edible healthy natural nutraceutical with high antioxidant properties and rich mineral elements based on fruits and medicinal plants. Antioxidant, Protein, and inorganic contents of fruits and natural herbal plants were determined to evaluate the contents of active constituents of the meal in milligrams. The results were then used to formulate an edible herbal supplement as a solid oral system. The raw protein content of each ingredient was evaluated through the Kjeldahl method. The contents of the nutrient elements were measured in mg/kg (D.W) by ICP-Mass. All components were mixed thoroughly in some proper percentages, milled, and then dried by heating for 48 hours. The Flowability of the powder was subsequently evaluated using the work index and Hausner ratio. The work index of the sample was 34.3, and because the Flowability was not optimal, aerosol was added to 10 grams of a mixture of 1% by weight of the material. Finally, the working index reached 23, which is desirable. Furthermore, the ingredients were volumetrically encapsulated in OO-sized capsules and subjected to quality control tests. Performing organoleptic assays for controlling the physical and chemical properties of the formulation, the active ingredient was determined in terms of the results of Kjeldahl and inductively coupled plasma Mass spectrometry (ICP-Mass). The results of all control tests, including the weight deviation test, opening time test, and active ingredient dosage test, were conducted for the developed formulation according to credible pharmacopeia. According to the allowable daily dosages, the developed capsule is a proper herbal supplement with very high antioxidants.
Strategi Peningkatan Kapabilitas Dinamis Perusahaan Properti
Authors: Munir Ningky Sasanti , Cahyono Rachmat Dwi , Patricia Mia Christy
Published: March 2024

Penelitian ini bertujuan untuk memahami kondisi kapabilitas dinamis (DC) perusahaan yang bergerak di bidang properti, khususnya strategi peningkatan yang perlu dilakukan untuk mempertahankan keunggulan kompetitifnya dalam lingkungan yang dinamis pasca pandemi Covid-19. Penelitian ini merupakan penelitian kualitatif dan bersifat terapan, dimana data diperoleh melalui wawancara direksi perusahaan, survai eksekutif level manajerial dan pengolahan data internal perusahaan. Hasil penelitian menunjukkan tiga prioritas DC yang perlu ditingkatkan perusahaan, yaitu Innovation Capability, Alliances/Networking Capability dan Operational Capability. Ketiga DC tersebut diperlukan untuk mengantisipasi ancaman dan peluang (sensing), memanfaatkan peluang dan mengurangi risiko (seizing) dengan melakukan transformasi (reconfigruing). Setelah mengetahui kesenjangan antara DC yang saat ini dimiliki dan DC yang seharusnya dimiliki, dilakukan penyusunan strategi peningkatan DC perusahaan.
Enterprise Risk Management dan Nilai Perusahaan: Kepemilikan Keluarga Sebagai Variabel Moderasi
Authors: Qalby Zahrin Haznina , Komalasari Puput Tri , Pradnyaswari Ni Luh Ayu Mahetria
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pengaruh Enterprise Risk Management terhadap nilai perusahaan dengan moderasi kepemilikan keluarga pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Penelitian ini menggunakan Moderated Regression Analysis (MRA) dengan utilisasi Process Macro v4.2 for SPSS by Andrew F. Hayes. Data sekunder yang digunakan dalam penelitian ini diperoleh dari Osiris dan website masing-masing perusahaan sampel, yang dipilih dengan teknik purposive sampling untuk periode penelitian 2015-2019. Variabel dependen pada penelitian ini adalah nilai perusahaan yang diukur dengan menggunakan Tobin’s Q. Variabel independen adalah Enterprise Risk Management (ERM) yang diukur dengan menggunakan indeks ERM kuantitatif. Variabel moderasi adalah kepemilikan keluarga yang diproksikan dengan nilai dummy. Penelitian ini juga menyertakan sejumlah variabel kontrol yaitu ukuran perusahaan (LnTA), profitabilitas (ROA), dan leverage (DAR). Hasil pengujian pada penelitian ini ditemukan bahwa ERM tidak berpengaruh signifikan terhadap nilai perusahaan, namun kepemilikan keluarga sebagai variabel moderasi memperkuat secara signifikan pengaruh positif ERM terhadap peningkatan nilai perusahaan. Variabel kontrol ukuran perusahaan tidak berpengaruh signifikan, profitabilitas berpengaruh negatif signifikan, dan leverage berpengaruh positif signifikan terhadap nilai perusahaan.
Comparative analysis of mother–infant interactions between free-ranging and captive rhesus macaques in Kathmandu, Nepal
Authors: Shrestha Smriti , Sharma Shailendra , Kyes Randall C. , Khanal Laxman
Published: March 2024

Rhesus macaques (Macaca mulatta) are gregarious, social primates whose infants depend on maternal support for survival. This study aimed to compare mother–infant interactions between free-ranging rhesus macaques (Swayambhunath Temple) and those in a captive setting (Central Zoo, Lalitpur) in Kathmandu, Nepal. Interactions such as duration of proximity and duration of contact between the dyads and symmetry, duration of out-of-proximity, duration of carrying or leaving by the mother while moving, and duration of nipple contact were compared. Five-minute focal animal sampling of maternal macaques was used to record the duration of mother–infant interactions. The behavioral state of the mother was also recorded via instantaneous scan sampling at one-minute intervals during focal samples. Our results revealed that the durations of proximity and contact were greater in the free-ranging macaques than in the zoo macaques. Similarly, the duration of carrying or leaving by the mother while moving was also greater in the free-ranging condition. The free-ranging mother–infant dyads spent significantly more time in nipple contact than did those in the captive setting. The infants were found to be primarily responsible for initiating both contact and proximity in the captivity. The symmetry for contact was balanced in free-ranging macaques; however, the infants were more responsible than the mothers for proximity behavior.
A systematic review of traditional health tourism: A priori of wellness tourism
Authors: Yan Linwei
Published: March 2024

This systematic literature review explores the research stream of traditional health tourism (THT) by covering a time frame of two decades. This research aimed to identify the key research areas and themes in the THT literature and proposed a research framework for further investigation. A total of 29 selected articles were analyzed and classified into seven categories, which included national contexts, products and services, driving factors, challenges in the development of THT and so forth. The analysis of the selected articles involved providing a descriptive analysis of the articles, followed by discussion of the content of the articles according to the themes. Additionally, gaps were identified in the literature on THTs. The research framework proposed in this review comprises eleven recommendations, which act as a roadmap for future investigations, encouraging researchers to engage in cross-cultural analyses, mixed-methods studies, and further investigations into different critical factors that affect THT. Thus, the review has significant implications because it provides a future research agenda, and the practical implications can be extended to the tourism industry and policymakers.
How did they become successful leaders? A qualitative study on the elements of leadership success in vocational and technical education
Authors: Al-Alawneh Muhammad Khaled
Published: March 2024

Successful educational institutions are often referred to as the product of successful leaders who lead these institutions with efficiency and the ability to achieve the institution's goals. Despite many published studies on leadership and leaders, few studies address the elements of leaders’ success as they are reported by themselves. The goal of this research was to identify the elements of the success of leaders that led them to be leaders. To achieve this goal, a qualitative research method was employed in which 42 in-depth interviews were conducted with educational leaders who worked or were still working in their institutions. The collected data were analyzed via conceptual analysis by coding and recoding to identify general concepts and themes related to the success of leaders. The results revealed that employability skills, personal characteristics, and committed values are the axes of these elements. The study recommended establishing courses, workshops, and conferences related to leadership and focusing on the elements of success to benefit future leaders from the experiences of educational leaders who served in the field and to improve leadership skills.