bluuebunny/crossref_metadata_2025 huggingface dataset:
Periprocedural Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant Undergoing a Digestive Endoscopy
Authors: Hansen-Barkun Christopher , Martel Myriam , Douketis James , Abraham Neena S. , Liederman Zachary , Kaplovitch Eric , Schulman Sam , Spyropoulos Alex C. , Majid Almadi , Barkun Alan N.
Published: November 2022

INTRODUCTION:

The periprocedural management of patients with atrial fibrillation (AF) using a direct oral anticoagulant (DOAC) undergoing elective gastrointestinal (GI) endoscopic procedure remains uncertain. We investigated the safety of a standardized periprocedural DOAC management strategy.

METHODS:

The Periprocedural Anticoagulation Use for Surgery Evaluation cohort study enrolled adult patients receiving a DOAC (apixaban, rivaroxaban, or dabigatran) for AF scheduled for an elective procedure or surgery. This analysis addresses patients undergoing digestive endoscopy. Standardized periprocedural management consisted of DOAC interruption 1 day preendoscopy with resumption 1 day after procedure at low-moderate risk of bleeding or 2 days in case of a high bleeding risk. Thirty-day outcomes included GI bleeding, thromboembolic events, and mortality.

RESULTS:

Of 556 patients on a DOAC (mean [SD] age of 72.5 [8.6] years; 37.4% female; mean CHADS2score 1.7 [1.0]), 8.6% were also on American Society of Anesthesiology (ASA) and 0.7% on clopidogrel. Most of the patients underwent colonoscopies (63.3%) or gastroscopies (14.0%), with 18.9% having both on the same procedural day. The mean total duration of DOAC interruption was 3.9 ± 1.6 days. Four patients experienced an arterial thromboembolic event (0.7%, 0.3%–1.8%) within 24.2 ± 5.9 days of DOAC interruption. GI bleeding events occurred in 2.5% (1.4%–4.2%) within 11.1 ± 8.1 days (range: 0.6; 25.5 days) of endoscopy, with major GI bleeding in 0.9% (0.4%–2.1%). Three patients died (0.5%; 0.2%–1.6%) 15.6–22.3 days after the endoscopy.

DISCUSSION:

After a contemporary standardized periprocedural management strategy, patients with AF undergoing DOAC therapy interruption for elective digestive endoscopy experienced low rates of arterial thromboembolism and major bleeding.
A Multimodal Multipath Artificial Intelligence System for Diagnosing Gastric Protruded Lesions on Endoscopy and Endoscopic Ultrasonography Images
Authors: Zhu Chang , Hua Yifei , Zhang Min , Wang Yun , Li Wenjie , Ding Yanbing , She Qiang , Zhang Weifeng , Si Xinmin , Kong Zihao , Liu Baiyun , Chen Weidao , Wu Jiangfen , Dang Yini , Zhang Guoxin
Published: November 2022

INTRODUCTION:

The aim of this study was to develop a novel artificial intelligence (AI) system that can automatically detect and classify protruded gastric lesions and help address the challenges of diagnostic accuracy and inter-reader variability encountered in routine diagnostic workflow.

METHODS:

We analyzed data from 1,366 participants who underwent gastroscopy at Jiangsu Provincial People's Hospital and Yangzhou First People's Hospital between December 2010 and December 2020. These patients were diagnosed with submucosal tumors (SMTs) including gastric stromal tumors (GISTs), gastric leiomyomas (GILs), and gastric ectopic pancreas (GEP). We trained and validated a multimodal, multipath AI system (MMP-AI) using the data set. We assessed the diagnostic performance of the proposed AI system using the area under the receiver-operating characteristic curve (AUC) and compared its performance with that of endoscopists with more than 5 years of experience in endoscopic diagnosis.

RESULTS:

In the ternary classification task among subtypes of SMTs using modality images, MMP-AI achieved the highest AUCs of 0.896, 0.890, and 0.999 for classifying GIST, GIL, and GEP, respectively. The performance of the model was verified using both external and internal longitudinal data sets. Compared with endoscopists, MMP-AI achieved higher recognition accuracy for SMTs.

DISCUSSION:

We developed a system called MMP-AI to identify protruding benign gastric lesions. This system can be used not only for white-light endoscope image recognition but also for endoscopic ultrasonography image analysis.
Putting TPACK into action in learning design: The case of PeerLAND
Authors: Papanikolaou Kyparisia , Makri Katerina , Sofos Ioannis , Tzelepi Maria , Zalavra Elena
Published: November 2022

Although previous research highlights the complementary relationship of learning design with TPACK, this is not the case for TPACK informing the development of digital learning design tools. In this paper, we present PeerLAND (Peer Evaluation of LeArNingDesigns). This learning design tool interweaves design and peer evaluation in an integrated process based on TPACK, promoting teachers' roles as designers and reviewers. It adopts a modular design approach to support teachers as designers explicitly represent their design ideas starting from pedadogical content knowledge and gradually cultivating all the TPACK knowledge domains. The learning design process ends with peer evaluation where teachers use TPACK-based criteria to provide constructive feedback to peers. We report on a study conducted in a teacher education context to evaluate PeerLAND. Specifically, we investigate: (i) how student teachers' knowledge develops through the learning design process supported by PeerLAND, and (ii) how they value peer evaluation through PeerLAND. Our findings suggest that putting TPACK into action through PeerLAND developed student teachers’ knowledge in every TPACK domain, except for content knowledge. Furthermore, peer evaluation is considered advantageous to student teachers for getting timely constructive feedback and refining their designs, and several ideas for improving the peer evaluation mechanism are proposed.
Implications for practice or policy:

PeerLAND is an online tool supporting the development and peer evaluation of technology-enhanced learning designs allowing teachers to work together and switch roles between designers and reviewers.
The learning design process in PeerLAND is a ready to use, step by step process for training teachers in technology-enhanced learning design. It provides a replicable blueprint for organising curricula.
An exploration of course and cohort communication spaces in Discord, Teams, and Moodle
Authors: Heinrich Eva , Thomas Heather , Kahu Ella R.
Published: November 2022

This research examined the impact of supplementing a learning management system, Moodle, with communication tools, Discord and Teams, to support communication in blended and distance undergraduate courses in computer science, information technology, mathematics and statistics at a New Zealand university with well-established use of Moodle. Nineteen students participated in semi-structured interviews. Findings show that adding Discord or Teams increases information and knowledge exchange and helps students to connect with peers and teachers in their courses. Teams was beneficial particularly in settings with formal group work. Discord, which enables both students and staff to set up additional communication channels that are not restricted to course enrolments, was instrumental in connecting students across year levels with peers and alumni. This enabled discussions on course selection, career options and disciplinary topics beyond the course curriculum. Importantly, these beyond-course communication spaces nurtured belonging to wider discipline and study communities. The research establishes the importance of the increased levels of communication by highlighting the effects on student learning and connections to others. Looking beyond the specific tools, the level of formality and the degree of student co-ownership are identified as key factors in supporting the within- and beyond-course communication spaces.
Implications for practice or policy:

Learning management systems provide valuable course support but do not meet all learning and teaching communication needs, partly due to their formal and university-controlled nature.
Educators and students benefit from using strong chat tools with improved information and knowledge exchange.
Both educators and students experience enhanced belonging when using collaboration and chat tools.
Students value Discord’s informality and student-led characteristics.
Educators who use Teams to support formal group work must carefully manage integration with Moodle.
Research issues of the top 100 cited articles on information literacy in higher education published from 2011 to 2020: A systematic review and co-citation network analysis
Authors: Chen Chao-Chen , Wang Ning-Chiao , Tang Kai-Yu , Tu Yun-Fang
Published: November 2022

Information literacy is a core research topic in the field of library and information science. The developmental context of this field can be examined through a long-term retrospective analysis of relevant literature. This study explored the research trends and potential research issues in the top 100 most frequently cited articles on information literacy in higher education published from 2011 to 2020. In addition to a systematic review, this study employed bibliometric methods, including co-citation network analysis, to identify four main research streams in the field of information literacy in higher education: (a) the relationships among students’ information literacy beliefs, competencies, attitudes and behaviour; (b) teachers’, librarians’ and students’ perspectives on information literacy; (c) the relationship between students’ information literacy and epistemic beliefs; and (d) the web search behaviour of digital natives. Accordingly, potential directions for future research and practitioner notes related to information literacy in higher education are proposed herein as a reference for researchers, teachers and policymakers.
Implications for practice or policy:

For administrators of higher educational institutions, understanding the challenges of new digital technologies and providing training to develop information literacy skills are crucial.
For teachers, designing teaching materials and pedagogy based on the latest information literacy standards and framework is useful.
Collaboration with professionals from different disciplines is also useful for teachers to integrate information literacy into subject learning activities to cultivate the information literacy competencies of students.
Bielefeld May In Fact Not Exist – Empirical Evidence From Official Population Data
Authors: Winter Patrick
Published: November 2022

The “Bielefeld conspiracy” has long disputed the existence of Bielefeld, a (supposed) German city. In this paper, an approach is developed to test such a theory empirically by auditing officially reported population numbers, arguing that real cities would not fake these. It is shown that Bielefeld’s data, in fact, violate the Benford law, a statistical law that they should follow if they were genuine. This anomaly is found only for Bielefeld, in contrast to all other tested similar and dissimilar cities, across two decades, and with highest significance by five statistical tests. The Bielefeld conspiracy remains as the most or even only plausible explanation for these findings.
Reception of the Bible in Rabbinic Liturgy: Expression and Interpretation
Authors: Kaunfer Elie
Published: November 2022

This essay explores two questions: How is the Bible received and expressed in classical rabbinic Jewish liturgy? What is the implication for the understanding and interpretation of Jewish prayer, given the role of the Bible in the liturgy? We will review the prevailing theories of the Bible’s reception in the liturgy and classify the different forms of this reception. We will then explore the implications for interpretation of liturgy by analyzing a piece of the daily Jewish liturgy—the first blessing of the amidah.
Design and analysis of high-speed data optical fiber communication system through EDFA amplifier system
Authors: Rashed Ahmed Nabih Zaki , Altahan Baraa Riyadh , Manasavenna Thaticharla , Ahammad S. K. Hasane , Priya P. Poorna , Krishna M. Rama , Hossain Md. Amzad , Smirani Lassaad K. , Nabil Ashraf Ali
Published: November 2022

This study presented design and analysis of high-speed data optical fiber communication system through EDFA amplifier system. The design with practical data for parameters to maximize the transmission bit-rate is clarified. The bit rate distance product can be optimized for the improvement of performance of high-speed long haul repeater spacing with amplification technique. The basic amplification system for optical fiber communication system is clarified. Transmitter/receiver components with the circuit connections and the operation are also indicated in details. The practical circuit model of the transmitter and receiver are designed clearly in this work. The design of distribution maps to measure the Q factor and minimum bit error rate and many different simulation models for applied to achieve high-speed data optical fiber communication system.
Slags from Bronze Age copper production in Acqua Fredda
Authors: Haubner R. , Strobl S.
Published: November 2022

So-called “plate slags” from the archaeological Bronze Age copper smelting site Acqua Fredda were examined. What was common to all the examined slags was that their compositions, once converted and plotted on the FeO-SiO2-CaO phase diagram, were located at the phase boundary between olivine and wollastonite, resulting in melting temperatures of approx. 1100 °C for the slags. Slags with a composition which fall within the olivine region exhibit long, thin olivine crystals in a glassy matrix. Slags in the wollastonite region have a very fine-grained structure, making phase identification impossible. The copper-containing inclusions in the slag mainly consist of Fe-poor Cu2S, but FeO and SiO2 may also be present.

General assertions about the local copper production in Acqua Fredda should not be made based on the slag analyses conducted in this study.
Microstructure of an extraordinary Bronze Age copper ingot with a high antimony content
Authors: Haubner R. , Strobl S.
Published: November 2022

The Cu ingot from Velem contains approximately 10 wt.% Sb, 4.5 wt.% As, 1.2 wt.% S and Ag, as well as other trace elements in an amount below 0.2 percent by weight. A Cu2S band running virtually across the entire width of the ingot suggests that it was formed by the reaction of molten Cu with antimonite (Sb2S3). Remarkably, the generated cutting surface was not copper-colored but had a silvery appearance which, however, can be attributed to the high Sb content. The metallographic examinations revealed a very inhomogeneous structural composition of the ingot. Large areas consist of dendritically solidified Cu, while the interdendritic areas are characterized by mixtures of different phases of the elements Cu-Sb-As-S.
Metallography on a sickle fragment from the Drassburg/Burgenland hoard find
Authors: Haubner R. , Strobl S.
Published: November 2022

The Drassburg Bronze Age hoard find (approx. 25 kg) also comprises some sickles and sickle fragments. One of these sickle fragments was provided for metallographic examinations. A XRF analysis revealed 94.5 wt.% Cu, 4.31 wt.% Sn, 0.61 wt.% Pb, and 0.12 wt.% S in the alloy. It can therefore be attributed to tin bronzes.

The material has a uniform dendritic microstructure. Higher concentrations of Sn, S, and Pb were measured in the interdendritic areas. This suggests a precipitation of the phases Pb and Cu2S from the residual melt. Klemm II etching also revealed the dendritic areas which exhibited different orientations.

Deformations were observed in thin edge areas of the sickle fragments. They were introduced in the course of mechanical postprocessing of the bronze or during its use.

The surface of the sickle exhibits a patina with a layered structure and a thickness of up to 500 μm. The Sn contents measured in the outer layers are somewhat higher than in the inner layers.
Radiation attenuation attributes for BaO-TiO2-SiO2-GeO2 glass series: a comprehensive study using Phy-X software
Authors: Abualsayed Mohammad Ibrahim
Published: November 2022

The radiation-shielding attributes of six glass samples with BaO-TiO2-SiO2-GeO2 compositions were examined. Using the Phy-X software, the radiation shielding factors for the proposed glasses were reported. The transmission factor (TF) was calculated for various glass thicknesses, and the findings showed that the TF reduces as the glass thickness increases. The transmission of the photon decreased for BTGS55 from 0.83 to 0.49 at 0.284 MeV and from 0.93 to 0.73 at 0.826 MeV as the sample thickness increased from 0.4 to 1.6 cm. The findings of the radiation protection efficiency (RPE) indicated that a thick glass sample absorbs more photons, suggesting that less radiation passes through the glass, improving RPE. Furthermore, the BTGS0 glass has a higher RPE than the BTGS55 glass, indicating that the glass is more effective at blocking incoming radiation when it contains more GeO2. The BTGS55 sample has the lowest RPE and the greatest TF, whereas the BTGS0 glass has the highest RPE and lowest TF. The tenth value layer (TVL) was also obtained, and it was found that TVL rises with energy, peaking at 1.33 MeV and varied from 9.437 to 11.519 cm. The minimal TVL, in contrast, is estimated to range between 3.245 and 3.890 cm and it occurs at 0.284 MeV BTGS0 has the lowest TVL after the addition of GeO2, which lowers the TVL.
Development of a Noble Fouling-Resistant Membrane for Wastewater Treatment
Authors: Ganesh Patil , Noura Al Balushi , Shabib Al Rashdi , Syed M. Rizwan , A.M. Saravanan
Published: November 2022

Membrane fouling is a serious matter in membrane operation that impacts the system's durability and cost. A noble fouling-resistant membrane was created to address this issue. A noble fouling-resistant membrane was made using copper oxide-graphene oxide (Cu2O-GO) and polyether sulfone. As copper has strong antimicrobial properties, the per-unit strength of graphene is the highest among the known materials in the world. The Cu2O-GO was incorporated into the polyether sulfone matrix using the phase inversion method. The effects of Cu2O-GO on the performance and antifouling properties of the membrane were investigated. The membrane structure and properties have also been characterized by using Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Spectroscopy (EDS), and Fourier-Transform Infrared Spectroscopy (FTIR). The SEM and EDX tests were carried out on the 0.1 wt %, 0.5 wt %, and 1 wt% of Cu2O membranes. Membrane performance in terms of wastewater treatment and fouling resistance of the prepared mixed matrix membranes was also studied. This project shows a new direction in the research as not many studies using Cu2O-GO has been reported worldwide.
Effect of vision therapy on fusional vergences in intermittent exotropia
Authors: Kumari Priyanka , Azam Shua , Abbas Shakila , Waheed Nusrat , Talpur Abdul Hameed , Bukhari Sadia
Published: November 2022

Significance: Intermittent exotropia is intermittently manifest squint at distance and latent exophoria at near. Most of the time, the eyes seems to be aligned with normal binocular single vision is maintained because its exodeviation is intermittently controlled by fusional mechanisms. Purpose: To evaluate the effect of vision therapy on fusional vergences in intermittent exotropia. Methods: This hospital-based, Quasi-Experimental study was carried out at the Orthoptics clinic of Al-Ibrahim Eye Hospital from August 2020 to July 2021. Non- probability, purposive sampling was used. This study involved the 40 subjects who were diagnosed with Intermittent Exotropia of age ranges 10 to 25 years, of both genders. A detailed history was evaluated. Orthoptics assessment included visual acuity, cover test, near the point of accommodation and convergence at a distance, and near and fusional vergences of positive and negative with prisms were measured. All subjects underwent vision therapies for 2 months. SPSS version 20.0 was used to analyze the data. Results: A total of 40 subjects with a mean age of 16.53±2.96 were included in this study. Out of 40 subjects, 22 subjects were females and 18 subjects were males. Subjects who received dot card therapy and executives bifocals therapy showed a significant change in the angle of deviation at distance and near (P=.001), followed by reduced the near point of convergence (P=.001), and increased the positive fusional vergences at distance and near (P=.001). There was no significant improvement seen in near point of accommodation (P=.16) with both therapies. Negative fusional vergences showed non-significant as (near: P=.14, distance: P=.05) with executives bifocals and (P=.26) with dot cards. Conclusions: This study showed that vision therapies with dot card and executive bifocals therapy have significantly improved the angle of deviation, positive fusional vergences, and near point of convergence in intermittent exotropia subjects.
Proton pump inhibitors: Are they safe?
Authors: TY Bando , LS di Pace , M Lapa , EZ Chehter
Published: November 2022

The number of Proton Pump Inhibitor (PPI) users has grown since the last decade. This greater use has come together with its inappropriate prescription, which is a result of its effectiveness and good tolerance. However, there is overuse and inappropriate use with excessive dose and duration. The literature reveals that long-term PPI use has side effects such as pneumonia, gastrointestinal cancer, dementia. These side effects need to be proved and have weak association. Further studies are necessary to elucidate them. This study will ascertain the relationship of PPIs and their long-term collateral effects. In this study, reviews from the last five years addressing the long-term use of PPIs and their possible side effects were sought in indexed databases (PubMed, SciELO and Lilacs). Fourteen articles and 21 relevant side effects were analyzed. The association with most of the reported side effects such as cancer, chronic kidney disease, dementia and community-acquired pneumonia (CAP) is denied. There was a positive association with gastric polyps, magnesium deficiency and acute interstitial nephritis. The side effects are widely spread and even if there is a positive association with some of them, the use of PPIs is likely safe, as the association was negative for more debilitating collateral effects.
A novel approach for the treatment of lysosomal acid lipase deficiency nonresponsive to conventional therapy regimen
Authors: Pandey Akash , de Boer Justin Adam , RN Irene Melo , Horvath Karoly
Published: November 2022

Lysosomal acid lipase deficiency (LAL-D), or cholesterol ester storage disease, is a rare inherited lipid metabolism disorder affecting the breakdown of cholesterol esters and triglycerides within lysosomes. The case of a 9 year old patient with growth retardation and hepatosplenomegaly had a confirmed diagnosis of LAL-D. The initial response to the recommended Sebelipase alfa enzyme replacement therapy in a biweekly infusion regimen was suboptimal; elevated lipid levels and transaminase elevations continued. After dose escalation by increasing the dose per infusion from 2.2mg/kg to 2.5mg/kg and change from a biweekly to a weekly infusion regimen resulted in significant improvement in the total cholesterol, triglycerides, low density lipoprotein and transaminases. To our knowledge this is the first report in the US on dose escalation and infusion frequency increase in a patient of this age, which resulted in improved short term outcome.
The utility of serum anti-tumour necrosis factor levels and biomarkers in predicting endoscopic activity in inflammatory bowel disease
Authors: Joel Tan Joel Tan , Neeman Teresa , Kavitha Subramaniam Kavitha Subramaniam
Published: November 2022

Introduction: Although higher anti-tumour necrosis factor (anti-TNF) levels are associated with higher rates of clinical remission, much less is known regarding the associations between biomarkers and endoscopic findings in patients with inflammatory bowel disease (IBD). Methods & methods: A retrospective analysis of patients with available anti-TNF levels attending an IBD clinic at a tertiary centre from 1st January 2014 – 31st May 2020 was completed. Demographics, disease activity scores, endoscopic findings and biomarker data were collected. The area-under-curve (AUC) on the receiver operating characteristic curve was plotted to measure and compare the performance of variables in predicting endoscopic remission. This was supplemented by linear discriminant analysis. Results: One hundred and eighty patients were included. Faecal calprotectin was better at distinguishing between quiescent and active endoscopic disease than anti-TNF level .AUC 0.78 (95% CI 0.68 – 0.89) versus 0.62 (95% CI 0.48 – 0.75). Faecal calprotectin had a higher sensitivity (77% vs 50%) and specificity (71% vs 64%) compared to anti TNF levels in predicting endoscopic activity. We found that a faecal calprotectin threshold of 200ug/g and similarly an anti TNF level of 6.21ug/ml optimally predicts endoscopic disease. Using linear discriminant analysis, faecal calprotectin was weighted against C-reactive protein (CRP), albumin, platelet count, anti-TNF, and has shown to be better at predicting mild to moderate disease activity (Log FC=0.74). Conclusion: Faecal calprotectin as opposed to anti-TNF level is more likely to predict endoscopic disease activity. We plan to do a prospective study to confirm these findings and to develop a set of clinical cut-offs to improve disease management.
Missed abdominal injury: why and how to deal? A retrospective interventional study
Authors: Pujahari Aswini K
Published: November 2022

Introduction: Literature is silent on missed abdominal surgery mostly because, it has become rare after the use of routine whole body CT scan. Even if missed, it remains so small a number and for fear of negative publicity, it goes unpublished. It is felt that, missing an abdominal injury must be having an altered final outcome on the patients. With this question in mind, the old data, kept prospectively was analysed, with an aim to find out the prevalence of missed abdominal injury, why were the injures were missed and how to deal with them early and effectively so as to have a possible positive change in the final outcome. Materials and methods: It was a retrospective interventional study from Jan 2002 to May 2017, where cases of blunt abdominal injuries were included and war/ insurgency related gunshot, penetrating and bowel injuries were excluded in two large military hospital in peace locations. Only cases with blunt injuries including the transferred patients from the other hospital were included in the study, where the injuries were missed at three level, namely clinically unsuspected, at CT scan and at laparotomy. Result: There were 72 patients with blunt abdominal injuries. There were 67 males and five females with age range from 8- 72 years (mean 30.70 SD13.759).Forty-three (43) patients were managed by observation and 18 patients were operated. Twelve (12) injuries were missed mostly due to, not suspecting an injury, un-conscious patient with severe head injury and misinterpretation of CT images. Six patients underwent laparoscopy. Only one patient, a laparotomy was avoided. There were three mortalities from the missed organ injury group. Conclusion: Missing an injury is presumed to be relatively uncommon. Mesenteric and isolated pancreatic injury are most often missed. Diagnostic laparoscopy confirms mesenteric injury and saponification of fat suggest pancreatic injury and duodenal injury even missed at laparotomy, when done very early.
Eosinophilic ulcerative colitis- case report and literaturereview
Authors: Soares Pereira Isabela Bercovici , Dantas Danilo Queiroz , Yarid Angelieri Taís Donha , Tanaka Daniel Yuji , Achar Eduardo , Francisco Carillo Neto Francisco Carillo Neto , Almeida Gentile João Kleber de
Published: November 2022

Eosinophilic colitis (EC) is a rare inflammatory disease that is part of the group of gastrointestinal eosinophilic diseases. Its etiology seems to involve allergic mechanisms comprising several interleukins and immune system cells (mainly eosinophils). It presents in distinct ways according to age, but at any stage of life it encompasses gastrointestinal symptoms. In addition, it is a condition with a predominance in males, according to some studies.
Taper up-off treatment of opium may reverse some dysregulations of gene expression patterns caused by four type of leukemia, AML, ALL, CML and CLL; a pilot animal model study
Authors: Dezhakam Hossein , Dezhakam Ani , Haghighatfard Arvin
Published: November 2022

Leukemia is a group of lethal diseases characterized by hematological neoplasm with complex and abnormalities in proliferation of bone marrow stem cells, that cause sever loss of functional capacity of hematopoietic tissue. Four most common types of leukemia are included acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML). It has been reported that opium besides of pain killer effects, may have positive effects on cardiovascular disease treatments. Opium may consider as a potential treatment method in cancer. The present study aimed to assess the gene expression pattern alterations in the rat models of four types of Leukemia (ALL, AML, CLL, and CML) under taper up-off treatment method with of opium. Present study was included twelve group, referred to four type of Leukemia (ALL, AML, CLL, and CML) that each type studied in three group. Group one contented normal rats, group two rat model of each type of leukemia with no treatment and group three the rat model of that type of leukemia with 26 days period of opium taper up-off treatment. After the scarification of rats, the bone marrow tissue were extracted. Then, RNA extraction and cDNA synthesis had been conducted on bone marrow tissues. Whole genome expression profiling was conducted by using the Affymetrix GeneChip Array Platform. Microarray results were confirmed by Real time PCR. Microarray analysis detected that hundreds of genes which were involved in Ontogenesis and apoptosis, humoral immune system, tool like receptors, natural killer cells regulators and metabolic pathways and were deregulated in leukemic models, were partially reregulated in treatment groups. Results showed that opium may have positive effects on reregulation of affected gene expression patterns in all types of leukemia. It may suggest that opium taper up-off treatment could be consider as re-regulator of immune system and a novel potential treatment for leukemia with low side effects and high viability.
Inventory of the fauna and flora of the Northeast new ecosystem of Bizerte lagoon (Tunisia), Southeastern Mediterranean sea
Authors: Mili Sami  , Enmouri Rim , Bouzuquita Cryine , Fatnessi Manel , Zarrouk Hajer
Published: November 2022

Bizerte lagoon is a valuable socio-economic ecosystem which is renowned for its significant biodiversity and its strategic position in the Mediterranean and in northern Tunisia. It is characterized by an important biodiversity and a high biological productivity, which makes of it a nursery for several marine species. It is also a place of brood stock maturation for others and a feeding area for many migratory species. Its shores and maritime space host lots of human activities, such as coastal fishing, shellfish farming, maritime traffic, recreational fishing and nautical sports, besides 277 industries spanning several sectors of activity such as leather and textile as well as the refining of hydrocarbons and the steel industry. These activities cause severe pollution and result in many anthropogenic disturbances. The aim of this work is to study the sanitary state of Bizerte Lagoon using a biological and ecosystem approach that exploits bio-ecological indicators at the scale of specimen, population, community or whole ecosystem. The findings of this study have revealed the following facts: the peri-lagoon part of the Northeast zone is distinguished by an interesting biological diversity. According to statistical descriptors, the most abundant and frequent zoological groups are gastropod mollusks followed by crustaceans. In terms of diversity indexes, the values obtained showed that the Northeast zone has a poor to mediocre ecological status. This research demonstrates that Bizerte Lagoon is undergoing an anthropic pressure that has been jeopardizing the biodiversity of this ecosystem.
Sustainability ecotourism in Ujung Kulon National Park, Banten
Authors: Hengky SH 
Published: November 2022

The Ujung Kulon National Parks (UKNP) is one of the most-strategic national parks in the island of Java with a population of 70% of the population of Indonesia. The national park is also located near the international airport. It closed to the capital city of Indonesia. The park is urban green area for them. However, research on the park is still lacking. Furthermore, the UKNP very rarely encountered or found in the literature. Its' role as the oxygen's producer for the communities. This study analyzed the sustainability of tourism in UKNP. Result analysis indicated the tourism ministry staff is expecting to utilize natural resources for ecotourism activity and local communities' cultural values, and social development as the first and second highest values. Instead, educating local communities to minimizing or mitigate negative environmental impacts, get the least ratings. The study found that UKNP implements the concept, but because of a lack of understanding - empowerment of communities in dealing with and solving problems caused by increasing urbanization and community housing development, as well as enhanced tourists’ awareness. The result indicates the need for further in-depth studies to understand and manage the problem.
Salivary gland condition before and after kidney transplantation: evaluation of salivary gland function in patients with end-stage chronic renal failure before and after kidney transplantation
Authors: Afanasyev Vasily , Youssef Dana
Published: November 2022

The authors conducted a study of the state of the salivary glands in 50 patients with end-stage chronic renal failure. There was a pronounced violation of the function of the salivary glands (SG) in these patients by the type of xerostomy, which led to a change in the qualitative and quantitative indicators of mixed saliva. After the kidney transplant, the function of the SG improved, but did not fully recover. At the same time, there was an improvement in the hygienic condition of the oral cavity. Saliva cleanses the mucous membrane of the mouth from bacteria and food. It also immunoglobulins and lysozyme are involved in the formation of oral immunity. Saliva forms a food lump and makes it easier to swallow food. A decrease in salivation leads to digestive disorders and tooth decay. All patients with end-stage chronic renal failure showed a dysfunction in the work of the SG. A decrease in kidney function led to a change in the composition and nature of salivation. With saliva, toxic products were excreted, which normally were excreted only by the kidneys. Normalisation of salivation occurred after hemodialysis. Patients after kidney transplantation require long-term follow-up and preventive therapy for the salivary glands in order to improve and restore their function. Currently, there is no information in the literature about the state of SG in patients after kidney transplantation. This was the basis for this work.
Microleakage of bulk fill polymer-based composite: review of the literature
Authors: Lafebre Carrasco Milton Fabricio , Taboada Brito Bryam Paul , Renteria Guerrero Viventa Jannett
Published: November 2022

Currently, the most widely used dental restoration materials in the field of dental aesthetics are polymer-based composite; therefore, the offer within the market is increasing with a focus on aesthetic, mechanical, and process improvement needs. Bulk fill or block filling polymer-based composite has been widely accepted, they have an advantage because they can be placed in blocks of up to 4 to 5 mm1 reducing clinical times in contrast to traditional polymer-based composite. Therefore, within the present study, we have focused on investigating the microleakage of this type of polymer-based composite and what are the main reasons for it. Objectives: A literature review on the evaluation of the degree of microleakage of bulk fills polymer-based composites. Methodology: An electronic literature search was performed on bibliographic bases such as PubMed, Scielo, Science Direct, Cochrane, and Wiley Online using the keywords: “marginal adaptation”, “bulk fill resin”, “bulk fill composite”, and “microleakage”. Conclusions: Block filling polymer-based composite tends to have the same amount of microleakage as conventional polymer-based composite. Adhesive systems are essential to greatly reduce the formation of gaps between dental materials and dental structures. Class II cavities will always be better to treat the proximal face first and then manage as a class I to reduce marginal microleakage. The fluid block filling polymer-based composite used as a base greatly helps the adaptation of the polymer-based composite and decreases marginal microleakage.
Directors of veterinary services in the Anglo-Egyptian Sudan: William (Bill) Kennedy, 9 September 1924-September 1934
Authors: Wilson R Trevor
Published: November 2022

William Kennedy was born in Scotland in 1884 and was elected a Member of the Royal College of Veterinary Surgeons (MRCVS) in 1908. Working in British East Africa (now largely Kenya) in the years before the First World War (!914-1918) as a Veterinary Officer he was in part responsible for ensuring the health of livestock moving from the northern Masai areas to a southern reserve and preventing disease being transmitted to the herds of white settlers. Kennedy served in the East African Veterinary Corps as a Major throughout the war, was on the Staff of the Commander in Chief when Britain was fighting the armed forces of German East Africa and where his main concern was to ensure the health of the large number of riding and transport animals. He was three times Mentioned in Despatches and awarded the Distinguished Service Order. After the war he was successively acting and then Chief Veterinary Officer of the Kenya Colony and Protectorate, issuing numerous proclamations designed to control rinderpest, contagious bovine pleuro-pneumonia and foot and mouth disease. Leaving Kenya in 1924 he was appointed Director of Veterinary Services in Sudan, the first civilian to occupy the position. He served in Sudan until 1934 during a period when disease identification, diagnosis and control made great progress. Honoured with the award of the Order of the Nile Third Class by the King of Egypt, he retired to England and died there aged 80 in 1965.
Climate change: a factor to farmers/herders crisis in Benue State, North Central, Nigeria
Authors: Alexander Chinago Budnukaeku
Published: November 2022

The study “Climate Change: A Factor to Farmers and Herders Crisis in Benue State, North Central” focused on the crisis of farmers and herders in relation to the climate reality of the region. The study used 34 years rainfall date (1981-2014) for analyses. The study observed that rainfall in the entire State displayed a mono peak characteristic. The high rainfall months are May, June, July, August and September, with September having the highest rainfall. The rainy season is duration when farmers plant and tend their crops, it coincide with the natural period of foliage growth and the period of herders movement to the region as a result of extreme rainfall in the Southern part of Nigeria and insufficient rainfall in the Northern part. This implies that the crisis between farmers and herders are most likely to occur between the months of May to October, while crops are still in the farm. The annual rainfall trend and dispersion shows that rainfall distribution over the years is increasing, improved rainfall implies that natural vegetation and water will be available for animals, thereby encouraging the in flock of herders and there animals, a situation which will increase the rate of confrontations. The rather increasing rate of crisis in the face of improved rainfall points to either excessive herders’ presence or that other factor, other than climate change is responsible for the crisis. The analysis of the decadal rainfall also shows that the rainfall situation is improving of recent. Negative dispersion is an indication of low crisis, while a positive dispersion from point of climate change is an indication of heighten crisis between farmers and herders. The study also observed that improved medical knowledge has also led to the crisis. Period to improvement in the field of medical science climate influence movement of herders due to the presence of tsetse flies, but as a result of vaccination herders are staying more permanent in the region than before. Finally, ranked correlation shows the relationship between climate shift and crises between farmers and herders.
Beyond localized muscular endurance: Strength and Power Training as a means to improve the Aerobic Runner
Authors: K Carroll Christopher
Published: November 2022

Objectives: The purpose of the paper is to highlight and demonstrate how to apply strength and power training to the endurance runner. This paper will discuss physiological adaptations beyond simply localized muscular endurance. Focused literature highlighting effects on oxygen consumption, lactate threshold, running economy and neuromuscular benefits will be further discussed. Search methods: A search was conducted on the wide-body of research that exists in and around the skeletal muscle and sports performance and aligns the research in a clear manner, specifically describing the physiological response of various training to the endurance athlete. Literature gathered involved trails of comparative analysis with control groups in various exercise settings. Main results: In an attempt to clarify the physiological adaptations specific to the endurance runner, the purpose of this paper is to demonstrate and describe how strength and power training can be used with aerobic athletes beyond just localized muscle endurance. The present paper identifies each adaptation specific to the training modality to clarify the scientific evidence for the sport practitioner. Conclusions: Historically, runners have eliminated strength exercises form their training programs due to theorized decreases in VO2max and Lactate Threshold. However, the majority of research analyzing those two variables has been conducted with stand-alone methodology. Concurrent strength and endurance training research has not displayed negative effects on in VO2max and Lactate Threshold and furthermore has produced favorable adaptions to both running economy and neuromuscular coordination delaying fatigue. It is therefore suggested endurance based runners perform strength and or power training to maximize running economy and delay fatigue.
Active displacement and sustainable development objectives applied to education
Authors: Sánchez Zafra María , Cachón Zagalaz Javier , Sanabrias Moreno Déborah , Zagalaz Sánchez María Luisa
Published: November 2022

The United Nations (UN) 2030 Agenda for Sustainable Development was unanimously adopted in September 2015. It presents 17 Sustainable Development Goals (SDGs) to eradicate poverty and protect the Earth, as well as ensure peace and prosperity. Among them, the 4th, which refers to education to improve the quality of life (QL) of people, is the basis of this article relating it to the 3rd on health and well-being, and the 11th which tries to make cities and human settlements sustainable. The objective is to demonstrate that active travel, mainly on foot and in cities, is a different, important and necessary form of Physical Activity (PA) that can be accessed through education. The training of Physical Education (PE) teachers in basic education is essential to achieve this objective. This paper presents the rationale for the practical application of active travel and contains a literature review that provides different city and author perspectives that reinforce the proposal. The research experience of the HUM653 Group, "Innovation in PA", adds educational innovation and leisure time management to the proposed objective, linking PA with teacher training, culture, the environment, and information and communication technologies (ICT) through activity designs, gymkhanas and GPS circuits, and the QL.
Іонізація молекул амінокислот тирозину та треоніну електронним ударом
Authors: Vukstich V.S. , Bohachov H.G. , Vasiliev O.V. , Remeta E.Yu.
Published: November 2022

Для молекули амiнокислоти тирозину вимiряно енергетичну залежнiсть перерiзу процесу однократної iонiзацiї електронним ударом та визначено його порiг. Нормуванням вiдносного перерiзу iонiзацiї, одержаного в експериментi, на теоретичнi величини визначено абсолютнi значення перерiзу. Потенцiали iонiзацiї молекул тирозину та треонiну оцiнено теоретично за енергiєю зв’язку їхньої найвищої зайнятої орбiталi. Характеристики молекулярних орбiталей було розраховано за методами Хартрi–Фока та теорiї функцiонала густини. Перерiзи однократної iонiзацiї D- та L форм вказаних молекул оцiнено у моделi Binary-Encounter-Bethe та за формулою Гризiнського.
Deformed Dirac and Shrödinger Equations with Improved Mie-Type Potential for Diatomic Molecules and Fermionic Particles in the Framework of Extended Quantum Mechanics Symmetries
Authors: Maireche A.
Published: November 2022

In this study, the bound-state solutions of the deformed Dirac equation (DDE) have been determined with the improved Mie-type potential including an improved Coulomb-like tensor potential (IMTPICLP) under the condition of the spin or pseudospin symmetry in the extended relativistic quantum mechanics (ERQM) symmetries. The IMTPICLP model includes a combination of the terms 1/r3 and 1/r4 which coupled with the couplings (LΘ and L̃︀Θ) between the physical properties of the system with the topological deformations of space-space. In the framework of the parametric Bopp’s shift method and standard perturbation theory, the new relativistic and nonrelativistic energy eigenvalues for the improved Mietype potential have been found. The new obtained values appeared sensitive to the quantum numbers (j, k, l,̃︀ l, s, s,̃︀ m, m̃︀ ), the mixed potential depths (A, B, C, α), and noncommutativity parameters (Θ, σ, χ). The new energy spectra of the improved Kratzer–Fues potential within an improved Coulomb-like tensor interaction and the improved modified Kratzer potential within the Coulomb-like tensor interaction have been derived as particular cases of IMTPICLP. We recovered the usual relativistic and nonrelativistic results from the literature by applying the three simultaneous limits (Θ, σ, χ) → (0, 0, 0). One can notice that our results are in close agreement with the recent studies.
Вплив атмосферного вуглекислого газу на показник кислотно-лужного балансу водних розчинів хлориду натрію
Authors: Stoliaryk O.D. , Khorolskyi O.V.
Published: November 2022

У роботi експериментально дослiджено вплив атмосферного вуглекислого газу на показник кислотно-лужного балансу розбавлених водних розчинiв хлориду натрiю в iнтервалi температур (294–323) К для концентрацiй, яким у середньому вiдповiдає 540, 675, 900 i 1620 молекул води на один iон натрiю або хлору. Розраховано часи релаксацiї показника кислотно-лужного балансу водних розчинiв хлориду натрiю при розчиненнi у них атмосферного вуглекислого газу в залежностi вiд температури та концентрацiї солi. Встановлено подiбнiсть поведiнки температурної залежностi часiв релаксацiї показника кислотно-лужного балансу розчинiв хлориду натрiю рiзних концентрацiй. Для з’ясування природи та особливостей подiбностi розраховано радiуси Дебая i показано, що у дослiджених нами розчинах внесок електростатичної взаємодiї не є визначальним, тому вона не буде вiдчутно впливати на молекулярнi процеси. Здiйснено спробу побудови строго теоретичного обґрунтування механiзмiв встановлення рiвноважного значення показника кислотно-лужного балансу чистої води i води при її контактi з атмосферним вуглекислим газом. Показано, що розрахунки за отриманими спiввiдношеннями добре корелюють з експериментальними результатами. Доведено, що атмосферний вуглекислий газ має суттєвий вплив на змiну показника кислотно-лужного балансу води i водних розчинiв хлориду натрiю.