bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioksidan Ekstrak Etanol Buah Kecipir Dengan Metode 1,1-Diphenyl-2-Picrylhidrazyl (DPPH)
Authors: Widiani Nurhaida , Irma Putri , Kamelia Marlina
Published: July 2023

The fruit of Psophocarpus tetragonolobus L thought to have an antioxidant activity such as seeds and leaves. Ethanol extract from winged bean contains saponins, flavonoids, polyphenols, steroids, and terpenoids. This study aims to determine the antioxidant activity of the ethanol extract of winged bean fruit using the DPPH (1,1-diphenyl-2-picrylhydrazyl). The antioxidant activity test of winged bean extract was carried out at concentrations of 10 ppm, 50 ppm, 100 ppm, and 150 ppm. Added with DPPH (50 ppm) of winged bean extract. Vitamin C was used as a positive control. Absorbance measurement to determine the antioxidant activity of winged bean using a UV-Vis spectrophotometer at a maximum wavelength of 517 nm. The results of this study obtained a qualitative color change in both the winged bean extract and vitamin C. The IC50 value winged bean extract was 98.3229 ppm and included strong antioxidant activity based on the Blois classification.AbstrakBuah kecipir (Psophocarpus tetragonolobus L) diduga memiliki aktivitas antioksidan seperti halnya biji dan daunnya. Ekstrak etanol dari buah kecipir mengandung saponin, flavonoid, polifenolat, steroid dan terpenoid. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol buah kecipir dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyl). Ekstrak buah kecipir didapat dengan cara maserasi menggunakan pelarut etanol. Uji aktivitas antioksidan ekstrak buah kecipir dilakukan pada konsentrasi 10 ppm, 50 ppm, 100 ppm, dan 150 ppm. Ekstrak buah kecipir ditambah dengan DPPH (50 ppm). Vitamin C digunakan sebagai kontrol positif. Pengukuran absorbansi untuk mengetahui aktivitas antioksidan buah kecipir menggunakan spektrofotometer UV-Vis pada panjang gelombang maksimum 517 nm. Hasil penelitian ini didapatkan perubahan warna secara kualitatif baik pada ekstrak buah kecipir dan vitamin C. Nilai IC50 ekstrak buah kecipir senilai 98,3229 ppm dan termasuk memiliki aktivitas antioksidan kuat.
Aktivitas Antimikroba Actinomycetes Hasil Isolasi Sedimen Mangrove Asal Kecamatan Bontoa Terhadap Sreptococcus mutans
Authors: Alhidayatullah Alhidayatullah , Putri Aziz A. Alfiana , Wahyuni Dwi Fitrah
Published: July 2023

Mangroves are one of the ecosystems that are rich in nutrients and contain a lot of organic matter used by microorganisms such as actinomycetes. Actinomycetes are gram-positive bacteria capable of producing bioactive compounds. Actinomycetes are microorganisms that produce secondary metabolites that have biological activity as antimicrobials. The purpose of this study was to determine whether there are actinomycetes in Bontoa District and the potential for actinomycetes in Bontoa District which have antibacterial activity against Streptococcus mutans. Isolation of actinomycetes was carried out using HVA media, then purified on YMEA media and tested the inhibition of actinomycetes using the diffusion method using MEA media. The results showed that the isolation results obtained 7 isolates of actinomycetes, namely AC1, AC2, AC3, AC4, AC5, AC6 and AC7. The inhibitory activities from the largest to the smallest were 10 mm, 9.5 mm, 9 mm, 8.5 mm and 8 mm, respectively. Actinomycetes found in Bonto Bahari Village, Bontoa District, Maros Regency had antimicrobial activity.AbstrakMangrove merupakan salah satu ekosistem yang kaya akan nutrisi dan memiliki banyak kandungan bahan organik yang digunakan oleh mikroorganisme seperti aktinomiset. Actinomycetes merupakan bakteri gram positif yang mampu menghasilkan senyawa bioaktif. Actinomycetes merupakan mikroorganisme penghasil metabolit sekunder yang memiliki aktivitas biologi sebagai antimikroba. Penelitian ini bertujuan untuk mengetahui keberadaan actinomycetes pada hutan mangrove di Kecamatan Bontoa dan potensi adanya actinomycetes di Kecamatan Bontoa yang memiliki aktivitas antibakteri terhadap Streptococcus mutans. Actinomycetes diisolasi dengan dengan menggunakan media HVA, lalu dipurifikasi dengan media YMEA. Uji daya hambat actinomycetes terhadap Streptococcus mutans dengan metode difusi menggunakan media MEA. Hasil penelitian menunjukkan bahwa dari hasil isolasi diperoleh 7 isolat actinomycetes yaitu AC1, AC2, AC3, AC4, AC5, AC6 dan AC7. Isolat dengan aktivitas daya hambat terbesar dan terkecil berturut-turut adalah isolat AC4 (9,6 mm) dan AC1 (8,3 mm). Terdapat actinomycetes di Desa Bonto Bahari Kecamatan Bontoa Kabupaten Maros yang memiliki aktivitas antimikroba terhadap Streptococcus mutans.
Long-term effect of disinfection on collodion light-sensitive layer
Authors: Benetková Barbora Mašek , Knotek Vítězslav , Ďurovič Michal
Published: July 2023

Cellulose nitrate in the form of collodion has been used as a light-sensitive layer since 1851. As such, collodion photographs are often found in cultural institutions. Because of its organic structure, it is susceptible to microbiological contamination and, therefore, a need for disinfection may occur. In such cases, the disinfection method must be effective and non-destructive towards the material and restorer. Since all tried disinfection methods were proven effective by cooperating microbiologists, the non-destructivity against material became the primary concern. Model samples were prepared, disinfected, and artificially aged; to observe any possible change in properties on a long-term scale. The properties measured were: change in colour, change in the content of nitrogen and change in the degree of polymerisation obtained by viscometric measurements. From the results, we could select a disinfection method that did not pose any measurable threat towards the collodion light-sensitive layer and, therefore, can be used in practice by restorers.
Counter imaginaries: Towards a new cartography of agency
Authors: Arora Sukhesh , Gamat Shena
Published: July 2023

Performance can foster social imagination, help us understand the connection between historical processes and personal experiences, and to see how social structures and forces shape our lives and identities. The use of performance can help both educators and learners to expose the pedagogies of oppression—how education can reproduce or reinforce the existing power relations and ideologies in society.
Acceptation de la vaccination contre la COVID-19 chez les patients en dialyse péritonéale au Sénégal
Authors: Ettoumi Hicham , Mbengue Mansour , Niang Abdou
Published: July 2023

Introductio
Ce travail avait pour objectif d’évaluer la couverture vaccinale chez les patients en dialyse péritonéale et de déterminer les facteurs associés à la non-vaccination.Patients et méthodesIl s’agissait d’une étude multicentrique, rétrospective, descriptive et analytique, réalisée sur une période de 6 mois, dans 4 unités de dialyse péritonéale. Les patients en dialyse péritonéale depuis au moins 3 mois étaient inclus.RésultatsQuarante-neuf patients étaient inclus dans notre étude. Parmi eux 30 (61,2%) étaient vaccinés contre la COVID-19 avec un sex-ratio de 0,8. Il y avait 83% des patients qui avaient reçu 2 doses. Il y avait 63,3% des patients qui avaient reçu le vaccin d’AstraZeneca, 33,3% celui de Sinopharm et 3,4% celui de Johnson & Johnson. Les effets indésirables étaient principalement une douleur au niveau du point d’inoculation dans 100% des cas et un syndrome grippal dans 25% des cas. La raison de la non vaccination était dans 42% des cas une peur des effets secondaires des vaccins et/ou une minimisation de la gravité de la COVID-19. Parmi les patients vaccinés, 2 (6,6%) avaient été testés positifs à la COVID-19 après vaccination dont un avec une forme sévère 3 mois après le vaccin. La moyenne d’âge des patients vaccinés était significativement plus élevée (47,6 ans) que celle des non vaccinés (37,6 ans) (p=0,048).ConclusionIl est primordial de continuer à appliquer les mesures de prévention de la COVID-19 dans les différents centres de dialyse péritonéale et d’encourager la vaccination ou la complétion des schémas vaccinaux notamment chez les plus jeunes.
Lactate ou bicarbonate dans le liquide de dialyse pour hémodialyse quotidienne à domicile : avantages et inconvénients
Authors: Petitclerc Thierry
Published: July 2023

La disponibilité depuis le début du XXème siècle de moniteurs d’hémodialyse apparentés aux cycleurs utilisés pour la dialyse péritonéale automatisée (moniteurs peu encombrants, de maniement simple, utilisant un faible volume de dialysat et adaptés à la dialyse quotidienne) a conduit à un regain d’intérêt pour l’hémodialyse à domicile. Comme en dialyse péritonéale, ces cycleurs utilisent un dialysat au lactate - un anion dont le métabolisme conduit à la régénération du bicarbonate – ou bien un dialysat au bicarbonate. L’objet de cet article est de faire le point sur les avantages et inconvénients de ces deux types d’anion alcalinisant. Quel que soit le type de dialysat utilisé, il importe d’éviter une alcalinisation trop importante du patient. Le dialysat au lactate, moins onéreux et de maniement plus facile, semble pouvoir être utilisé chez la plupart des patients, mais son utilisation chez ceux d’entre eux présentant un bilan hépatique anormal devrait être déconseillée.
DETERMINATION OF THE PRIORITY SCALE OF FLOOD MANAGEMENT IN THE LANDAK SUB-WATERSHED
Authors: Akafi M. Ma'ruf , Soeryamassoeka SB , Gunarto Danang , Nirmala Azwa , Danial Mochammad Meddy
Published: July 2023

The Landak Sub Watershed is part of Indonesia's Kapuas River Basin, covering an area of approximately 7,921 km2 and comprising three administrative regions: Landak Regency, Kubu Raya Regency, and Pontianak City. Like other regions in Indonesia, the frequency of flood events in the Landak Sub Watershed has been increasing each year, becoming a severe problem as it has caused losses for the community. Therefore, a study is needed to provide an overview of the most suitable flood management measures to minimize floods in the Landak Sub Watershed.This article presents the research results to determine the priority scale of flood mitigation measures suitable for implementation in the Landak Sub Watershed using the Analytic Hierarchy Process (AHP). The determination of criteria, sub-criteria, and flood management alternatives is based on the results of a Focus Group Discussion (FGD) held in Ngabang City on August 30, 2022. The selected flood management alternatives combine both structural and non-structural measures. Once the hierarchy is established, a questionnaire is distributed to determine the appropriate options for flood mitigation in the Landak Sub Watershed.The study results indicate that the priority scale for flood mitigation in the Landak Sub Watershed is by revising regulations and policies. The analysis shows that the priority criterion is Law and Institutions with a weight of 0.376, the priority sub-criterion is Legislation with a weight of 0.213, and the priority alternative is the revision of regulations and policies with a weight of 0.1984. For the correction of rules and procedures to be effectively carried out, all stakeholders related to flood control in the Landak Sub Watershed must be involved.
Evaluación electrofisiológica e immunohistológica de canales SK en ventrículo humano: expresión funcional en patología valvular
Authors: Pérez Martínez Alba , Pueyo Esther , Oliván Aida
Published: July 2023

Se ha evaluado la presencia y funcionalidad de los canales SK en muestras de tejido ventricular procedentes de pacientes con patología valvular y en muestras de control. Se ha demostrado que los canales SK están presentes en todos los pacientes, pero únicamente pueden ser activados en los pacientes con patología valvular.
Metastasis on Chip: Modelling Invasive Breast Cancer Cells
Authors: Sharko Gandabura Vira , Perisé Ismael , Morato Laura , Antón Antonio , Solanas Estela , Ochoa Ignacio
Published: July 2023

The purpose of this work is to employ a three-dimensional model to examine breast cancer metastasis from various perspectives. Using a solid breast tumor model exposed to a standard chemotherapeutic treatment scheme, we aim to replicate the earliest stages of the metastatic cascade, focusing on the drug's effect on invasive cells.
Interactive Media Innovation Articulate Storyline Animation to Improve Fast Drawing Ability of Art and Design Students Universitas Negeri Malang
Authors: Prasetyo Abdul Rahman , Widodo Triyono
Published: July 2023

Student creativity in drawing projects is far from learning outcomes, where visual objects tend to be imitative. Therefore, student creativity needs to be honed again in order to optimize skills. In addition, it is also due to the lack of learning media used by teachers for students. This study aims to produce interactive learning media that is fun and uses technology in the painting competence of art and design students at the State University of Malang. The method used in this study uses the Moeljadi Pranata development model, namely five-D which consists of Define, Data, Design, Development, Disseminate. Data collection through observation, interviews, validation, and field trials. Observations were made at the Department of Art and Design, State University of Malang and conducted interviews with art lecturers and student representatives. This development resulted in an interactive media product, Articulate Storyline. The results of the study show that the use of interactive media Articulate Storyline can improve students' ability to make pictorial works more quickly. After using the media students are more interested in learning because the views of the material provided are more practical and unique. Apart from that, there is also a demonstration video in this media which can help students to make images more easily. This media development product is packaged creatively and interactively. This is supported by the validation results of media experts and material experts as well as field trials in small groups.
Evaluación sensorial de una bebida de orégano adicionada con glutamina
Authors: Téllez-Girón S.O. , García Mendoza L.A. , Hernández Miranda Y. , Rodríguez Castillo E. L. , Sosa Morales M.E.
Published: July 2023

Actualmente en México y en otros países muchas personas han comenzado un cambio en su rutina, incluyendo activación de forma física. Sin embargo, debido a que no están acostumbrados ajercitarse, tienden a presentar molestias musculares. En los períodos de intensa actividad física el organismo puede exceder la capacidad de sintetizar glutamina. Debido a esto, la glutamina se convierte en esencial ya que el organismo, no puede cubrir la demanda existente. La glutamina es un aminoácido que ejerce propiedades reguladoras independientes de su metabolismo que se origina a través del aumento del volumen celular, como la modulación de la renovación de proteínas y del glucógeno, aumentando el anabolismo muscular. Para este proyecto, se propuso una bebida de orégano adicionada con glutamina, que pueda ser consumida y coadyuve a mitigar las afectaciones musculares sin ser un suplemento. Se realizaron dos pruebas sensoriales (prueba de ordenación y afectiva hedónica), para su elaboración participaron 20 jueces no entrenados que evaluaron parámetros de acidez, dulzor, color y aceptabilidad general. Para el parámetro de acidez y color no existe diferencia significativa entre las formulaciones (p>0.05); sim embargo, los parámetros de dulzor y aceptabilidad general fueron afectados por el tipo de formulación (p<0.05). Por lo tanto, la formulación que se recomienda para continuar su desarrollo incluye 3 ml de jugo de limón, 1 ml de colorante líquido, 14 g de miel y 5 g de glutamina.
Efektifitas Perangkat Pembelajaran Fisika Model Inkuiri Terbimbing Berbantuan Laboratorium Virtual untuk Meningkatkan Keterampilan Berpikir Kreatif Peserta Didik
Authors: Satria Raka Panji , Sahidu Hairunisyah , Susilawati Susilawati
Published: July 2023

This study aims to determine the effectiveness of guided inquiry learning models assisted by virtual laboratories to improve students' creative thinking skills. This type of research is Research and Development (R&D) with a 4D model consisting of Define, Design, Develop, and Disseminate. Products developed in the form of a syllabus, online learning implementation plans, student worksheets, and creative thinking skills test instruments. effectiveness obtained from limited trials to get the N-gain score. The results showed an increase in the value of creative thinking skills with the greatest increase in the flexibility indicator of 0.64 in the medium category. So it can be concluded that the guided inquiry model physics learning device assisted by a virtual laboratory is effective for improving the creative thinking skills of students, especially on indicators of flexibility.
Membangun Strategi Pemasaran dalam Meningkatkan Daya Saing Bisnis Pasca Pandemi Covid-19
Authors: Abdurrahman Abdurrahman , Rahayu Nila , Genadi Yeldi Dwi , Pradnyani I.G.A. Arista
Published: July 2023

This study entitled Establishing Marketing Strategy to Improve Competitive Advantage of Business Pasca Pandemic Covid-19. The aim is to determine the effect of marketing strategy in increasing business competitiveness after the Covid-19 pandemic. The objects of this research are business actors, in this case students at the Faculty of Economics and Business who own businesses and have been running for at least one year. The sampling technique used in this study is Quota Sampling, where the number of samples has been determined in advance, in this case the respondents are business actors from students who are members of the Student Preneuship Program at the Faculty of Economics and Business, University of Mataram.  Analysis and testing of hypotheses used the Statistical Package for the Social Sciences (SPSS) with research instruments using questionnaires which were distributed online with the help of Google forms. The analysis carried out in this research is multiple linear regression analysis, while the testing stages are validity test, reliability test, multiple regression analysis, hypothesis testing through F test and t test, with product moment correlation coefficient. From the regression analysis, the equation is obtained Y = 1.013 + 0.471X1 + 0.251X1 + 0.382X3 + 0.211X4. Hypothesis testing using the F test shows that the four independent variables studied are proven to simultaneously influence purchasing decisions, where the value of F count> F table (7.514 > 2.58).
The experience of teaching public speaking in the paradigm of training specialists in the field of political sciences
Authors: Mangova Oksana Borisovna
Published: July 2023

The chapter substantiates the importance of mastering competencies related to the implementation of public speech for professionally oriented teaching of foreign languages. The author shares experience of teaching public speaking while training future specialists in the field of political science, and describes the model of preparing public speeches. As an example, the public speech of Bono, a well-known activist and leader of U2, is analyzed, and examples of the expressive means used by him are given. This speech can be used as a sample when teaching public speaking to students.
PEMANFAATAN SYAIR GULUNG DAN WORDWALL PADA PEMBELAJARAN MENULIS PUISI BERBASIS PELAJAR PANCASILA PADA SEKOLAH PENGGERAK
Authors: Syahroni NFn , Andayani NFn , Suhita Raheni
Published: July 2023

Writing competencies demand mastery of other language skills, as writing is perceived to be the most significant aspect of language, especially poetry, which has distinct characteristics. However, despite the fact that learning to write poetry is challenging, it plays a crucial role in literature and education. In this regard, it can affect students' character and personality, broaden their perspectives on life, and improve their language skills. In order to achieve the predetermined goals, contextual learning materials and media must be tailored to the nature and needs of the students. In the context of this research, the materials were ancient poetry texts in the form of verses synchronized with the Wordwall media. The incorporated material and media were determined based on the Pancasila student profile. Researchers employed a qualitative research design with a descriptive method. The study was conducted in three senior high schools in North Kayong Regency, West Kalimantan Province, which implemented the Sekolah Penggerak program. Three Indonesian language teachers and nine students from the three schools participated in this research. The results demonstrated the significance of six Syair Gulung containing Pancasila student profiles that were deemed practical and entertaining as learning materials. Thus, the combination of Syair Gulung and the Wordwall media was viewed as effective for teaching students how to write poetry. AbstrakMenguasai keterampilan menulis harus menguasai keterampilan berbahasa lainnya, karena menulis merupakan aspek kebahasaan tertinggi. Terlebih lagi menulis puisi yang memiliki sifat bahasa yang khas. Namun demikian, walaupun pembelajaran menulis puisi yang merupakan pembelajaran dengan kategori rumit, namun memiliki peranan penting dalam sastra dan dunia pendidikan. Peran tersebut dapat mempengaruhi watak, kepribadian, memperluas wawasan kehidupan, dan meningkatkan kemampuan berbahasa murid. Dalam hal pemenuhan tujuan pembelajaran tersebut diperlukan materi dan media pembelajaran yang kontekstual sesuai kodrat dan kebutuhan murid. Materi tersebut berupa teks puisi lama berbentuk syair yang dielaraskan dengan media wordwall. Materi dan media tersebut sebagai bentuk pembelajaran berdeferensiasi dengan basis profil pelajar Pancasila. Metode penelitian ini adalah metode kualitatif dengan bentuk deskriptif. Sasaran penelitian ini adalah sekolah penggerak tingkat SMA di Kabupaten Kayong Utara Provinsi Kalimantan Barat yang berjumlah 3 sekolah. Subyek penelitian ini adalah 3 guru bahasa Indonesia serta 9 murid yang berasal dari 3 sekolah. Hasil penelitian ini mendeskripsikan makna 6 syair gulung yang memiliki kandungan profil pelajar Pancasila yang efektif dan menyenangkan untuk digunakan sebagai materi pembelajaran. Syair gulung dengan media wordwall merupakan kombinasi yang berdampak pada terpenuhinya kebutuhan murid dalam pembelajaran menulis puisi.
Efektifitas Digital Marketing dalam Meningkatkan Penjualan pada UMKM Kel. Siti Rejo
Authors: Maharani Sofia , Nazmah Nazmah
Published: July 2023

Penelitian ini dilakukan untuk mengetahui seberapa efektif pengunaan digital marketing dalam meningkatkan penjualan pada UMKM. Penelitian ini menggunakan metode penelitian kualitatif deduktif dimana teori digunakan sebagai awal menjawab pertanyaan penelitian, dalam penelitian ini memberikan pandangan menurut penelitian terdahulu dengan menggunakan teori sebagai alat, ukuran dan instrument yang digunakan dalam membuktikan hipotesis. Pertanyaan yang disusun berdasarkan indikator dari variable yang diberikan, Adapun yang menjadi sampel penelitian adalah UMKM yang bergerak dibidang kecantikan sebanyak 3 UMKM kel. Siti rejo II. Pada penelitian ini diketahui bahwa efektifitas dari pengunaan media sosial dalam peningkatan penjualan saat dikatakan memiliki kontribusi yang cukup baik, keaktifan pelaku usaha dalam mengunakan media sosialnya memiliki kontribusi. Penggunaan digital marketing menjadi strategi yang efektif dalam peningkatan penjualan. Pengunaan media sosial merupakan salah satu strategi untuk menarik minat konsumen serta menginformasikan kepada konsumen mengenai produk yang kita miliki.This research was conducted to find out how effective the use of digital marketing is in increasing sales to MSMEs. This study uses a deductive qualitative research method where theory is used as a starting point for answering research questions, in this study providing views according to previous studies using theory as a tool, measure and instrument used in proving the hypothesis. The questions were prepared based on the indicators of the variables given. As for the research sample, there were 3 SMEs working in the beauty sector. Sitirejo II. In this study it is known that the effectiveness of using social media in increasing sales when it is said to have a fairly good contribution, the activeness of business actors in using social media has a contribution. The use of digital marketing is an effective strategy for increasing sales. The use of social media is a strategy to attract consumer interest and inform consumers about the products we have
Análise do conceito enfermeiro especialista segundo Walker e Avant: scoping review
Authors: Melo Bianca Calheiros Cardoso de , Costa Jéssika Wanessa Soares , Silva Fillipi André dos Santos , Medeiros Katarine Florencio de , Medeiros Katarine Florencio de , Fernandes Maria Isabel da Conceição Dias , Lira Ana Luisa Brandão de Carvalho , Medeiros Soraya Maria de
Published: July 2023

O presente estudo tem como objetivo analisar o conceito enfermeiro especialista na perspectiva de Walker e Avant. Trata-se de uma análise conceitual, realizada por meio de uma scoping review, em dezembro de 2022. O estudo seguiu o método de análise de conceito proposto pelas autoras Walker e Avant. A amostra final foi composta por 15 artigos. Os resultados revelaram o conceito de enfermeiro especialista como sendo o profissional que possui expertise teórico e prática em uma área do conhecimento específica. É capaz de otimizar os cuidados em saúde de forma integral, em todos os níveis de atenção à saúde, mediante aprimoramento do conhecimento, mudanças de comportamento e valores éticos-morais. Conclui-se que o presente estudo permitiu identificar na literatura os elementos centrais do conceito de interesse, sendo importante para a clarificação do mesmo para uso ampliado na ciência e no cotidiano prático da enfermagem.
Effectiveness of Convalescent Plasma Therapy in Critically Ill COVID-19 Patients: Early Experience from a Dedicated ICU of Bangladesh
Authors: Al Momen Shahjad Hossain Md , Akhter Afroza , Rashid Md Harun Ur , Sultana Rumana , Islam Md Zahedul
Published: July 2023

Introduction: The management of severe or critical COVID-19 patients in the ICU includes supportivecare as well as repurposed drugs and revival of old strategies like human convalescent plasma therapy(CPT) in the absence of specific therapy against SARS-CoV-2 virus. CPT appears to be an attractivetreatment option as passive antibody transfer, but efficacy remains controversial.
Objectives: To determine the effectiveness of convalescent plasma therapy in management of criticallyillCOVID-19 patients admitted at the dedicated intensive care unit of Kurmitola General Hospital, Dhaka.
Study Method: All patients admitted in the ICU of Kurmitola General Hospital, Dhaka from 1st May to30th September 2020 were included in this retrospective observational cohort study. The protocolwasapproved by the Ethical and Scientific Committee of the hospital. The clinical and treatment data ofall participants were collected; and the association of CPT and mortality benefit was observed betweenthe patients who received plasma therapy during ICU stay and who didn’t. The statistical analysis wasperformed using the Windows based statistical software package SPSS version 25.
Results: A total of 228 critically illCOVID-19 patients were admitted to the ICU of Kurmitola GeneralHospital in the specified time period. Among them, 160 (70%) were male and 68 (30%) females. Mean agewas 57.97 (95% CI 56.23-59.70) years. Important co-morbidities were obstructive airway diseases 160(70.17%), hypertension 117 (51.31%) and diabetes mellitus 103 (45.17%). Only 53 (23.25%) patients receivedCPT during ICU stay. The median day of receiving CPT from the day of symptom onset was 12 (IQR 10-14) days in the survivor group and 18 (IQR 16-19) days in the non-survivor group (p<0.0001). All-causeICU mortality was 29 (54.7%) in CPT group vs. 115 (65.7%) in Non-CPT group (p=0.146). The odds ratioof survival in CPT group was 0.757 (95% CI 0.528-1.085).
Conclusion: This retrospective cross-sectional study suggested that the efficacy of use of convalescentplasma in critical or severe COVID-19 patients admitted to ICU is conflicting for mortality benefit.
JBSA 2021; 34(1): 26-31
Current Issues of the Use and Efficacy of Direct Oral Anticoagulants According their Pharmacogenetic Features
Authors: Gantsgorn E. V. , Safronenko A. V. , Gubin E. V. , Vlasenko V. A. , Rashkova E. V. , Malleev I. M. , Ivanov A. V. , Gerasyuta S. S. , Bulguryan G. A. , Osipenko Ya. O. , Denisenko O. V. , Saakyan D. A. , Ivanova M. H.
Published: July 2023

Despite the proven efficacy and relative safety of direct oral anticoagulants (DOAC), the issue of reducing the risk of complications associated with their use, depending on the genetic characteristics of patients, remains controversial. A personalized approach to the selection of DOAC should be developed. In this article, we review the available information on the feasibility of prescribing DOAC to patients with various diseases associated with hypercoagulation and on pharmacogenetic aspects of the DOAC application. The need for further research is substantiated, along with the importance of a wider introduction of the molecular-biological analysis of gene polymorphisms, whose presence affects the efficacy and safety of these drugs. In the course of the work, publications from the MedScape, PubMed, and eLIBRARY databases were analyzed.
Balón de resucitación aórtico endovascular (REBOA) para el control de la hemorragia no compresible de torso. Revisión de la evidencia.
Authors: Ramos Perkis Juan Pablo , Ortega Ruiz Jhonatan , Loaiza medina Paula Daniela , Zinco Acosta Analia , Ottolino Lavarte Pablo
Published: July 2023

La Hemorragia no compresible de torso, continua siendo unas de las principales causas de mortalidad del paciente víctima de trauma. El control de este tipo de sangrado, requiere de procedimientos invasivos como la toracotomia de reanimación, la cual se realiza en el paciente “in extremis”.La utilización de REBOA se re-introduce desde el 2011, como una forma de oclusión endovascular de la aorta y con el tiempo ya forma parte de los implementos que cuenta un centro de trauma nivel I. Actualmente REBOA se utiliza dentro del proceso de reanimación, mientras se realiza el control definitivo de un sangrado en el torso, con el fin de aumentar la perfusion de órganos como cerebro y corazón existiendo dos zonas principales de oclusión a nivel aórtico.Múltiples investigaciones se han realizado para encontrar las indicaciones y beneficios de REBOA dentro de la atención integral de un paciente con trauma grave, estando aun estas en desarrollo. La utilización en un paciente con trauma grave se encuentra protocolizada en diferentes pasos que van desde el acceso arterial hasta el seguimiento de la extremidad post retiro del introductor.Por este ultimo punto, REBOA se encuentra dentro de los implementos importantes de la reanimación, sin embargo no reemplaza conceptos básicos como atención integral del paciente politraumatizado, control precoz del sangrado y el control de daños resucitativo. Su implementación requiere de un centro altamente protocolizado y con equipos de trauma establecidos con el objetivo disminuir las complicaciones y optimizar la supervivencia.
Recent Archaeological Survey of Gidan Boji Settlement Site at Kwatarkwashi, Zamfara State, North-Western Nigeria
Authors: Ishaq Ishaq Isah , Yusuf Rabi’u , Abubakar Mohammed Nasiru
Published: July 2023

This paper presents a report and the findings of an archaeological survey carried out at Gidan Boji, an ancient settlement site in the Kwatarkwashi area in Zamfara State, northwestern Nigeria. The Kwatarkwashi area is one of the early centres of human occupation in Hausaland. The paper identified new sites of ancient human settlements in the Kwatarkwashi area that have not been described by previous studies. However, the most impressive of these newly identified sites in terms of size and structure is the Gidan Boji, which is the focus of this paper. The survey yields a wealth of archaeological finds including traces of homesteads, granary foundations, different types of defensive systems, grinding stones and pottery. Above all, the existence of defensive walls and several cave shelters suggests a fairly developed system of defense. This further confirms the existence of a settled society which a fairly well-developed material culture at a particular time in the past. For a clearer picture of the history, peopling and settlement pattern of Gidan Boji to be understood, the paper call for more attention towards systematic documentation of the entire sites and excavation around the Kwatarkwashi inselbergs. With more funds and collaborations, thorough archaeological investigation can be activated to study different aspects of the cultural history of the area as a similitude to the Nok Culture archaeological project.
PENGEMBANGAN MEDIA PEMBELAJARAN VIDEO ANIMASI PADA MATA PELAJARAN MATEMATIKA MATERI BANGUN DATAR KELAS IV SDN 04 KOTO BARU KABUPATEN DHARMASRAYA
Authors: Ratnawati  , Yulia Darniyanti  , Neri Setiani
Published: July 2023

This research is motivated by the lack of creative and innovative learning media so that students find it difficult to understand the material presented by educators, efforts to overcome this problem are the need to develop animated video learning media that can attract students' attention because of attractive images and colors. This type of research is Research and Development (R&D) research using the ADDIE model which consists of several stages (Analyze, Design, Development, Implementation, and Evaluation). The test subjects were class IV students at SDN 04 Koto Baru. Data collection instruments use validity instruments, practicality instruments, and effectiveness instruments. The assessment instrument was validated by three validators namely content/material, media and language, then the practicality sheet was determined by the practitioner. The effectiveness of animated videos is determined from the learning outcomes of class IV students at SDN 04 Koto Baru using animated videos. The results of the validation carried out by three validators obtained an average validity value of 85% with a very valid category in the sense that the animated video for learning Mathematics is suitable for use by students. The results of the practicality value of the educator's response questionnaire obtained an average of 89.99% in the very practical category. The results of the practicality value of the student response questionnaire obtained an average of 90.56% in the very practical category, so that the teacher and student response questionnaire obtained an average of 90.27% in the sense that it was easy for students to use and time efficient. The results of the effectiveness value of 10 students who took part in learning using the media developed on the Flat Shape material stated that 90% complete was categorized as very effective so that it was easy to use and very efficient in terms of time.
Separate and Combined Effective Coding of Bit Planes of Grayscale Images
Authors: Al-Furaiji Oday , Tsviatkou Viktar , Sadiq Baqir
Published: July 2023

Currently, an approach involving a coder with a combined structure for compressing images combining several different coders, the system for connecting them to various bit planes, and the control system for these connections have not been studied. Thus, there is a need to develop a structure and study the effectiveness of a combined codec for compressing images of various types without loss in the spatial domain based on arithmetic and (Run-Length Encoding) RLE-coding algorithms. The essence of separate effective coding is to use independent coders of the same type or one coder connected to the planes alternately in order to compress the higher and lower bit planes of the image or their combinations. In this paper, the results of studying the effectiveness of using a combination of arithmetic and RLE coding for several types of images are presented. As a result of developing this structure, the effectiveness of combined coding for compressing the differences in the channels of hyperspectral images (HSI) has been established, as hyperspectral images consist of multi-spectral bands, instead of just the typical three bands (RGB) or (YCbCr) found in regular images. Where, each pixel in a hyperspectral image represents the entire spectrum of light reflected by the object or scene at that particular location.
Identification of Cracks in Functionally Graded Material Beams Using the H-Version of Finite Element Method
Authors: Hassaine Narimane , Fellah Ahmed
Published: July 2023

In this article, we analyze the effect of transverse cracks on the natural frequencies of a Euler-Bernoulli functional gradient beam. The studied beam was discretized into finite elements and the global matrices of the motion equation are determined by applying the Lagrange equation to the beam kinetic and deformation energies. The material properties are considered to vary in the directions of the beam thickness, the gradation is described by the power-law distribution, the stiffness of the cracked element is determined based on the reduction of the beam cross-section. The numerical results obtained are compared with those available in the previous study. Finally, case studies were carried out to analyses the influence of the power law index, the depth and the opposition of the crack on the natural frequencies of the beam for different boundary conditions; these studies demonstrate the advantage of the FGM beam over the purely metal beam.
Influence of the M&A of Agricultural Companies on the Development of the Rural Areas
Authors: Honcharenk Iryna
Published: July 2023

"The purpose of the study is to establish the main areas of influence of agribusiness, through the conclusion of M&A transactions on the development of adjacent rural areas and non-agricultural businesses. The authors used methods: generalisation-systematisation of scientific provisions; analogy and comparison – characteristics of changes in agricultural companies after the conclusion of M&A transactions; analysis and synthesis – features of the functioning of agricultural companies and their impact on the development of rural areas; algorithmization – definition of conceptual provisions for improving the problem under study. The areas of the impact of agribusiness on rural development were substantiated to achieve the goals of the study. The study describes the M&A market in the context of the most influential economic sectors of the country, highlighting the role and place of the agricultural sector. The values of land plots in land banks of the ten largest agricultural enterprises of Ukraine are analysed. A comparative description of individual agrarian companies that were parties to M&A transactions for 2020–2022 is conducted. A number of factors that affect the development of rural areas after the conclusion of M&A transactions are identified. It is determined that the regional development policy should be based on mutual cooperation between rural communities and agricultural companies. The practical significance of the study is that the consolidation of agricultural companies and the expansion of their field of influence on the region, including through active cooperation with local communities, will allow for achieving high indicators of socio-economic development in rural areas."
DETERMINAN HIPERTENSI DI KABUPATEN MINAHASA SULAWESI UTARA
Authors: Podayow Marini , Nelwan Jeini Ester , Mantjoro Eva Marianne , Kaunang Wulan Pingkan Julia , Tucunan Ardiansa A.T.
Published: July 2023

Hypertension or what is often called high blood pressure usually occurs at systolic blood pressure ≥140mmHg and diastolic blood pressure ≥90mmHg. Hypertension has several factors that can trigger (determinant) the occurrence of hypertension, including the risk factors of age, gender and nutritional status. This study aims to determine the determinants of hypertension in Minahasa District, North Sulawesi Province. This is an observational study with a cross-sectional approach. The sample used was 110 respondents. The sampling method is simple random method. The variables studied were the incidence of hypertension, age, gender and nutritional status. This study used form sheets, tensimeters, height meters, weight scales, and computers. The statistical test used was the chi square test with a significance level of 95% (α = 0.05). The results showed that there was a correlation between age and hypertension (p-value = 0.002), and there was no correlation between gender and hypertension (p-value = 0.819) and there was a correlation between nutritional status and hypertension (p value = 0.003). It can be concluded that age and nutritional status were determinants of the incidence of hypertension in Minahasa Regency.
HUBUNGAN KEPATUHAN PEMBATASAN CAIRAN DENGAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS
Authors: Bandola Yanita Isyabella , Artini Budi , Nancye Pandeirot M
Published: July 2023

Kepatuhan merupakan masalah yang sering dialami pasien hemodialisis dan dapat berdampak terhadap berbagai aspek perawatan pasien,termasuk obat-obatan dan rejimen pengobatan serta pembatasan makanan dan cairan Diperlukan kepatuhan dalam proses penatalaksanaan hemodialisis untuk mencapai kualitas hidup yang lebih baik. Tujuan : Menganalisis hubungan tingkat kepatuhan pembatasan cairan dengan kualitas hidup pasien gagal ginjal kronik yang menjalani hemodialisis. Metode : Desain penelitian ini adalah kuantitatif analisis korelasional dengan pendekatan cross sectional. Jumlah populasi pada penelitian ini adalah 66 yaitu seluruh pasien penyakit gagal ginjal kronik yang menjalani hemodialisis. Pengambilan sampel dilakukan dengan cara consercutive sampling didapatkan 32 responden.Instrumen penelitian menggunakan kusioner KDQOL-SF dan kusioner kepatuhan pembatasan cairan. Hasil penelitian : Menunjukan kepatuhan pembatasan cairan pasien gagal ginjal kronik terbanyak responden kategori cukup patuh 18 responden (56.2%) dan kualitas hidup responden terbanyak kategori buruk 26 responden (81.2%). Setelah dilakukan ujistatistik Chi Square didapatkan hasil p=0,530 yang artinya p value>0,05 menunjukan bahwa Ha ditolak. Kesimpulan : tidak ada hubungan yang signifikan antara kepatuhan pembatasan cairan dengan kualitas hidup gagal ginjal kronik yang menjalani hemodialisis. Diskuai : upaya untuk meningkatkan kepatuhan pasien terhadap pembatasan cairan perlu selalu dilakukan edukasi tentang kepatuhan pembatasan cairan serta mencari faktor-faktor lain yang dapat berhubungan dengan kualitas hidup pasien GGK yang menjalani hemodialisis.

 

Kata kunci : Kepatuhan pembatasan cairan, Kualitas hidup, Gagal ginjal kronik
MELANIN: THE PHILOSOPHICAL STONE OF MOLECULAR BIOLOGY AND ITS IMPLICATIONS ON DISSOLVED OXYGEN LEVELS IN WATER AND FERTILITY OF AGRICULTURAL SOIL
Authors: Herrera Arturo Solís , Carmen Arias Esparza María del , Solís Arias Martha Patricia
Published: July 2023

Two fundamental problems now are: the growing contamination of water throughout the world, and the progressive loss of fertility of agricultural soil. The lack of revenue is a significant impediment to financing water. Water pollution is a key part of the climate change. Unless the water sector addresses efficiently the challenges inhibiting creditworthiness, new sources of revenue aren´t likely to flow to the water sector. There are two ways to pay for water infrastructure: tariffs and taxes. Worldwide, there is the cycle of “building” water infrastructure, and then “neglecting” it by not maintaining or repairing these assets because the resources aren’t available. Specifically, when local governments, water utilities, and other providers can significantly expands their collection systems efficiently, improves significantly water quality, reducing the non-revenue water, and decrease energy costs, then they can become viable, efficient, safe, and bankable service providers. Current methods to improve water quality date back to the French Revolution, and to date they are carried out on a larger scale, with more sophistication, greater energy expenditure, more CO2 emissions, greater production of toxic sludge, and yet, the quality of the water is not better, on the contrary it is declining as the contamination of the water continues to be incessantly, increasingly, cumulative and more and more complex. Despite the centuries that have passed, one factor has gone relatively disregarded: the levels of dissolved oxygen in the water and in soil. The better the quality of the water, the higher the levels of dissolved oxygen, and vice versa. Which also applies to agricultural soil, because the more oxygen is present, the more fertile the soil and vice versa. Addressing the low levels of dissolved oxygen in the water, until now it seems that it is considered as something secondary, as if it were something accessory, something like a parameter that would even improve spontaneously as soon as the levels of contamination of the precious liquid improve. But this has not happened so far with any method and in any part of the world. In addition to a lack of interest in developing processes to raise dissolved oxygen levels in the water and soil, there is the problem that the few available to date are too expensive. But the discovery of the unsuspected capacity of the human body to extract oxygen from water, dissociating it like plants; it means a light at the end of the tunnel.
KIẾN THỨC, THỰC HÀNH PHÒNG CHỐNG BỆNH VIÊM GAN B CỦA NGƯỜI NHÀ NGƯỜI BỆNH VIÊM GAN B TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG NĂM 2022
Authors: Mai Thị Thu Hiền , Thân Mạnh HùnG , Bế Hồng Thu
Published: July 2023

Mục tiêu: Mô tả kiến thức, thực hành về phòng chống bệnh viêm gan B của người nhà người bệnh viêm gan B và tìm hiểu một số yếu tố liên quan đến kiến thức và thực hành phòng chống bệnh viêm gan B của đối tượng nghiên cứu. Phương pháp: 400 người nhà bệnh nhân Viêm gan B khám và điều trị ngoại trú tại khoa Khám bệnh tham gia vào nghiên cứu. Nghiên cứu mô tả cắt ngang có phân tích. Kết quả: Kiến thức dự phòng viêm gan B của người nhà bệnh nhân là Đạt là 37,8% (Điểm trung bình (24,55 ±2,21)/29 điểm), mức chưa đạt là 62,3% (Điểm trung bình: (13,71±4,24)/29 điểm); Thực hành dự phòng viêm gan B của người nhà bệnh nhân ở mức đạt là 76,3% (Điểm trung bình: (8,65 ±1,05)/10 điểm), mức chưa đạt là 23,8% (điểm trung bình (4,80±11,29)/10 điểm); Tuổi trên 40 có tỷ lệ kiến thức không đạt cao hơn nhóm dưới 40 tuổi (p=0,001; OR=2,12); sống ở nông thôn, miền núi có tỷ lệ kiến thức không đạt cao hơn nhóm thành thị (p=0,00; OR=3,53); trình độ THPT trở xuống có tỷ lệ kiến thức không đạt cao hơn nhóm trên THPT (p=0,00; OR=5,12); nông dân, công nhân, sinh viên có tỷ lệ kiến thức không đạt cao hơn nhóm cán bộ, hưu trí (p=0,000; OR=8,38);
TÌNH TRẠNG KHÁNG KHÁNG SINH VÀ MỘT SỐ GEN KHÁNG THUỐC CỦA STREPTOCOCCUS SUIS GÂY BỆNH TRÊN NGƯỜI
Authors: Thân Mạnh Hùng , Vũ Đình Phú , Lê Văn Nam
Published: July 2023

Streptococcus suis gây ra bệnh cảnh đa dạng trên người, bệnh có khả năng gây dịch với tỷ lệ tử vong cao, đặc biệt trên nhóm bệnh nhân sốc nhiễm khuẩn. Mục tiêu: Phân tích tình trạng kháng kháng sinh và biểu hiện một gen kháng thuốc của S. suis gây bệnh trên người. Phương pháp: Tiến cứu, quan sát, phân tích tình trạng kháng kháng sinh của Streptococcus suis bằng kĩ thuật E-test và tìm hiểu một số gen kháng thuốc của S. suis. Kết quả: Bệnh chủ yếu ở nam giới (90%), 100% các chủng S. suis nhạy cảm với các kháng sinh nhóm penicilin, ampicilin, ceftriaxone, linezolid, và vancomycin. Kháng sinh có tỷ lệ kháng cao: erythromycin (76,3%), clindamycin (73,5%) và tetracyclin (97,6%). Phát hiện các gen kháng kháng sinh bao gồm: ant(6) với 78,75%, tet(B) với 75%, tet(O) với 28,75% và erm(B) với 60%. Kết luận: Streptococcus suis còn nhạy cảm với các loại kháng sinh thường sử dụng trên lâm sàng như penicilin, ampicilin, ceftriaxone. Có sự tương ứng giữa tần xuất xuất hiện các gen kháng thuốc với tình trạng kháng kháng sinh trên kháng sinh đồ.