bluuebunny/crossref_metadata_2025 huggingface dataset:
The Pvc15 D2-Pnf SP Interaction Mediates AAA ATPase Activity, Payload Stability, and Translocation into the PVC Tube Lumen
Authors: Evans Rhys , Waterfield Nicholas R.
Published: August 2023

ThePhotorhabdusvirulence cassette (PVC) is an elegant, multi-protein, contractile nanostructure which injects functionally bioactive polypeptides into the eukaryotic cytosol. Signal peptides (SPs) are N-terminal amino acid motifs from native ‘payload’ proteins which can also associate wide range of heterologous proteins to the PVC tube lumen. In addition, Pvc15 is a classic AAA ATPase encoded within the PVC operon which encodes an N-domain and tandem AAA domains D1 and D2. This work finds that Pvc15’s ATPase activity is mediated by the E555 residue situated in the Walker B motif of the sole functional ATPase domain, D2. Pvc15 multimerisation may be required to translocate payload into the PVC tube lumen, which is facilitated by intact N and D1 domains. In addition, ATPase activity requires the presence of other PVC operon components which hints at a PVC-regulated mode of action for loading. Furthermore, D2 is a chaperone for the native Pnf SP, though C-terminal truncations of the Pnf SP confers Pvc15-independent stability to the payload. These findings provide insight into the nuanced roles of the Pvc15-SP interaction for payload-PVC association and the effects that SP length and type has on payload stability and PVC-loading ability.
A neuronal relay mediates muscle-adipose communication that drives systemic metabolic adaptation to high-sugar diets
Authors: Kubrak Olga , Joergensen Anne F. , Koyama Takashi , Nagy Stanislav , Lassen Mette , Hald Jacob , Madsen Dennis , Halberg Kenneth V. , Texada Michael J. , Hansen Jakob L. , Rewitz Kim
Published: August 2023

Obesity leads to impaired insulin signaling and tissue sensitivity, which drive the onset of type 2 diabetes. Insulin resistance leads to a reduction in cellular glucose uptake, resulting in elevated blood glucose levels, which consequently cause β-cell dysfunction and development of diabetes. Although improving insulin signaling is a key target for restoring whole-body glucose homeostasis and reversing diabetes, the multi-organ mechanisms that regulate insulin signaling and tissue sensitivity are poorly defined. We screened the secretome and receptome inDrosophilato identify the underlying interorgan hormonal crosstalk affecting diet-induced insulin resistance and obesity. We identified complex interplay between muscle, neuronal, and fat tissues, mediated by the conserved BMP and LGR signaling pathways, which augments insulin signaling and improves dietary sugar tolerance. We found that muscle-derived BMP signaling is induced by sugar and governs neuronal Bursicon signaling. Acting through its LGR-family receptor, Bursicon both enhances insulin secretion and improves insulin sensitivity in adipose tissue, thereby preventing sugar-induced hyperglycemia. Inhibition of Bursicon-LGR signaling in adipose tissue exacerbates sugar-induced insulin resistance, and we discovered that this condition could be alleviated by suppressing NF-κB signaling. Our findings identify a muscle-neuronal-fat tissue axis that drives metabolic adaptation to high-sugar conditions by modulating insulin secretion and adipocyte insulin sensitivity, highlighting mechanisms that may be exploited for the development of strategies for the treatment and reversal of insulin resistance.
Signals and noise: communicating achievement through alternative credentials
Authors: Bean Martin , Grant Sheryl , Hardaker Glenn , Ward Rupert
Published: August 2023

Purpose

Alternative credentials are rapidly evolving. The purpose of this paper is to explore the challenges and opportunities arising from this evolution with particular reference to their role in education and employment.

Design/methodology/approach

The paper explores the credential initiatives with a unique perspective from introducing alternative credential initiatives that have been influential in recent national policy developments. The paper is led by the experiences of the former General Manager of Microsoft's Education Products Group, former Vice-Chancellor of The Open University and the Royal Melbourne Institute of Technology University. His experiences and lessons learnt reflecting on alternative credential development during the last 30 years provides a unique insight in seeing the “signals” and moving beyond the “noise” of micro-credentials for successful integration into educational institutions.

Findings

A number of key findings are identified in terms of current development challenges that impact on alternative credential use and identifying further developments. Relevant examples and references are provided throughout, with a particular focus on North America, Europe and Australasia where the most progress has been made in alternative credentials.

Research limitations/implications

Implications for those wishing to develop badging and microcredentialing solutions, especially in higher education, are identified for all seeking to maximise the success of alternative credential systems.

Originality/value

Martin Bean has a unique perspective having explored credential initiatives whilst General Manager of Microsoft's Education Products Group and whilst Vice-Chancellor of The Open University and the Royal Melbourne Institute of Technology University. Martin Bean has also been influential in recent national policy developments in Australia. Martin Bean’s experiences and lessons learnt witnessing alternative credential development during the last 30 years across three continents, and within both public and private sectors, are summarised here to provide context for discussions of some of the key global concepts and related work.
Broadband Internet and Cognitive Functioning*
Authors: Ackermann Klaus , Awaworyi Churchill Sefa , Smyth Russell
Published: August 2023

We empirically examine the impact of high‐speed internet access on cognitive functioning using data from the Household, Income and Labour Dynamics in Australia survey and crystallised and fluid intelligence measures. Leveraging differences in the National Broadband Network rollout across Australia, we find that high‐speed internet access causes a decline in crystallised intelligence and that the effects are mediated by social capital and moderated by age and gender. Although no overall effect on fluid intelligence was observed, a decline was noted in young adults. These findings underline the nuanced influence of high‐speed internet access on different aspects of cognitive function.
Inhibition of p38MAPK signalling pathway alleviates radiation‐induced testicular damage through improving spermatogenesis
Authors: Yang Juan , Ou Xiangying , Shu Manling , Wang Jie , Zhang Xuan , Wu Zhenyu , Hao Wei , Zeng Huihong , Shao Lijian
Published: August 2023

Background and Purpose

Damage to the testis following exposure to ionizing radiation has become an urgent problem to be solved. Here we have investigated if inhibition of p38 mitogen‐activated protein kinase (p38MAPK) signalling could alleviate radiation‐induced testicular damage.

Experimental Approach

In mice exposed to whole body radiation (2‐6 Gy), morphological changes of the epididymis and testis was measured by histochemical staining. immunohistochemical and immunofluorescence procedures and western blotting were used to monitor expression and cellular location of proteins. Expression of genes was assessed by qPCR and RNA‐Seq was used to profile gene expression.

Key Results

Exposure to ionizing radiation induced dose‐dependent damage to mouse testis. The sperm quality decreased at 6 and 8 weeks after 6 Gy X‐ray radiation. Radiation decreased PLZF+ cells and increased SOX9+ cells, and affected the expression of 969 genes, compared with data from non‐irradiated mice. Expression of genes related to p38MAPK were enriched by GO analysis and were increased in the irradiated testis, and confirmed by qPCR. Levels of phospho‐p38MAPK protein increased at 28 days after irradiation. In irradiated mice, SB203580 treatment increased spermatozoa, SOX9+ cells, the area and diameter of seminiferous tubules, sperm movement rate and density. Furthermore, SB203580 treatment increased SCP3+ cells, accelerating the process of spermatogenesis.

Conclusion and Implications

Exposure to ionizing radiation clearly changed gene expression in mouse testis, involving activation of p38MAPK signalling pathways. Inhibition of p38MAPK by SB203580 partly alleviated the testicular damage caused by radiation and accelerated the recovery of sperms through promoting spermatogenesis.
Estimated lifetime benefit of novel pharmacological therapies in patients with type 2 diabetes and chronic kidney disease: A joint analysis of randomized controlled clinical trials
Authors: Heerspink Hiddo J. L. , Vart Priya , Jongs Niels , Neuen Brendon L. , Bakris George , Claggett Brian , Vaduganathan Muthiah , McCausland Finnian , Docherty Kieran F. , Jhund Pardeep S. , Solomon Scott D. , Perkovic Vlado , McMurray John J. V.
Published: August 2023

Aim

To estimate the lifetime benefit of a combination treatment of sodium‐glucose co‐transporter 2 (SGLT2) inhibitors and mineralocorticoid‐receptor antagonists (MRA) in patients with type 2 diabetes and chronic kidney disease (CKD).

Materials and Methods

The cumulative effect of combination treatment was derived from trial‐level estimates of the effect of an SGLT2 inhibitor (canagliflozin) and MRA (finerenone) from the CREDENCE (N = 4401) and FIDELIO (N = 5734) trials, respectively. The cumulative effect was applied to the control group of patients with type 2 diabetes in the DAPA‐CKD trial (N = 1451) to estimate long‐term gains in event‐free and overall survival. The analysis was repeated in an observational study. The primary outcome was a composite endpoint of doubling of serum creatinine, end‐stage kidney disease or death because of kidney failure.

Results

The hazard ratio of combination treatment for the primary outcome was 0.50 [95% confidence interval (CI): 0.44, 0.57]. At age 50 years, the estimated event‐free survival from the primary outcome was 16.7 years (95% CI: 18.1, 21.0) with combination treatment versus 10.0 years (95% CI: 6.8, 12.3) with angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers resulting in an incremental gain of 6.7 years (95% CI: 5.5, 7.9). In an observational study, the estimated gain in event‐free survival regarding primary outcome was 6.3 years (95% CI: 5.2, 7.3). In a conservative scenario, assuming low adherence (70% of the observed adherence) and less pronounced efficacy (70% of the observed efficacy with 2% yearly decline) of combination therapy, gain in event‐free survival regarding primary outcome was 2.5 years (95% CI: 2.0, 2.9).

Conclusions

Combined disease‐modifying treatment with an SGLT2 inhibitor and MRA in patients with type 2 diabetes and CKD may substantially increase the number of years free from kidney failure and mortality.
Development of a novel Fc fusion protein dual glucagon‐like peptide‐1 and gastric inhibitory polypeptide receptor agonists
Authors: Jiang Peng , Sun Ningyuan , Yang Wen , Xiao Lin , Zhou Linjun , Gu Baohua , Li Yong , Li Lijia , Li Jing , Li Xiaoping , Li Wenjia , Guo Linfeng
Published: August 2023

Aim

To develop and investigate an imbalanced dual gastric inhibitory polypeptide receptor (GIPR)/glucagon‐like peptide‐1 receptor (GLP‐1 R) agonist with Fc fusion protein structure.

Methods

We designed and constructed an Fc fusion protein that is a dual agonist (HEC‐CG115) with an empirically optimized potency ratio for GLP‐1R and GIPR. The long‐term effects of HEC‐CG115 on body weight and glycaemic control were evaluated in diet‐induced obese mice and diabetic db/db mice. Repeat dose toxicity assays were performed to investigate the safety profile of HEC‐CG115 in Sprague‐Dawley rats.

Results

HEC‐CG115 displayed high potency for GIPR and relatively low potency for GLP‐1R, and we labelled it ‘imbalanced’. In animal models, HEC‐CG115 (3 nmol/kg) led to more weight loss than semaglutide at a higher dose (10 nmol/kg) in diet‐induced obese model mice. HEC‐CG115 (one dose every 3 days) reduced fasting blood glucose and glycated haemoglobin levels similar to those after semaglutide (once daily) at the same dose. In a 4‐week subcutaneous toxicity study conducted to assess the biosafety of HEC‐CG115, the no observed adverse effect level was determined to be 3 mg/kg.

Conclusion

HEC‐CG115 is a novel Fc fusion protein with imbalanced dual agonism that shows superior weight loss, glycaemic control and metabolic improvement in animal models, and has an optimal safety profile according to a repeat‐dose toxicity study. Therefore, the use of HEC‐CG115 appears to be safe and effective for the treatment of obesity and type 2 diabetes.
Size, but not sex, predicts pinch force and exoskeleton mechanical properties in crayfish of the genus Faxonius
Authors: Benson Derek M. , Clotfelter Ethan D.
Published: August 2023

Studies of animal weaponry and defensive structures rarely take into consideration their underlying mechanical properties. We measured the compressive strength and thickness of the exoskeleton of the claw (chela) in two North American crayfish species, Faxonius virilis and F. limosus. We performed similar measures on the carapace, a body region not directly involved in agonistic contests. Males of both species generated significantly stronger maximum pinch forces than females. However, these differences can be attributed to differences in claw size between the sexes. The thickness (ultrastructure) of the claw exoskeleton was a significant predictor of its compressive strength and likely explained the difference in compressive strength we observed between the two species. Neither claw thickness nor claw compressive strength was correlated with maximum pinch force. Additionally, we found that crayfish body size was a strong predictor of carapace compressive strength and thickness, whereas sex was not. The claw had greater compressive strength and thickness than the corresponding values for the carapace. Our study shows that the mechanical properties of the crayfish exoskeleton are largely a function of size and highlights the need to integrate mechanical properties into studies of animal morphology and performance.
Gastrointestinal hospitalization during COVID‐19 pandemic in the United States: Analysis of a nationwide inpatient sample
Authors: Wang Yichen , Huang Yuting , Zheng Ting , Sun Chenyu , Yang Keming , Pang Maoyin
Published: August 2023

Background and Aim

We aim to systematically investigate gastrointestinal (GI) hospitalizations in the United States during the early phase of the COVID‐19 pandemic on a national level and the consequence that may inform practice and policies.

Methods

A retrospective cross‐sectional analysis of adult hospitalizations with GI‐related diagnoses or procedures in the United States in 2020 was used, with hospitalizations from 2016 to 2019 used for contextual information.

Results

Hospitalizations with principal and secondary GI diagnoses decreased by 13.3% and 8.2% from 2019 to 2020, respectively. Most GI diagnoses decreased in 2020, with a few exceptions including alcoholic liver disease (increased by 7.8% as a principal diagnosis) and acute liver failure (increased by 11.6% as a secondary diagnosis). The mortality rate of hospitalizations with GI disease increased in 2020 compared with 2019 (for principal diagnosis: adjusted odds ratio 1.08, 95% confidence interval 1.03–1.13, P = 0.001; for secondary diagnosis: adjusted odds ratio 1.10, 95% confidence interval 1.07–1.13, P < 0.001). Most GI procedures decreased except for a notable 8.3% increase in gastrostomy. The per‐GI‐hospitalization rate of procedures increased for hospitalizations with a principal GI diagnosis (56.4% vs 55.6%, P = 0.003) or unchanged for hospitalizations with secondary GI diagnoses (18.3% vs 18.2%, P = 0.512).

Conclusion

The COVID‐19 pandemic resulted in a decrease in the volume of GI hospitalizations and procedures in 2020, but there was an increase in the mortality rate and some specific diagnoses including alcoholic liver disease and acute liver failure. These findings will likely enlighten future research and healthcare resource allocation for GI diseases.
Physiologic hormone administration improves HbA1C in Native Americans with type 2 diabetes: A retrospective study and review of insulin secretion and action
Authors: Rebello Candida J. , Morales Tyler S. , Chuon Katsya , Dong Shu , Lam V. Tyrone , Purner Dan , Lewis Stanley , Lakey Jonathan , Beyl Robbie A. , Greenway Frank L.
Published: August 2023

Insulin is secreted in pulses from pancreatic beta‐cells, and these oscillations maintain fasting plasma glucose levels within a narrow normal range. Within islets, beta‐cells exhibit tight synchronization of regular oscillations. This control circuit is disrupted in type 2 diabetes, and irregularities in pulse frequency and amplitude occur. The prevalence of type 2 diabetes is three times higher in American Indian and Native Alaskans compared to Whites, and their genetic ancestry is associated with low beta‐cell function. Obesity in this population compounds their vulnerability to adverse outcomes. The purpose of this article is to review insulin secretion and action and its interaction with race. We also present the results from a 6‐month retrospective chart review of metabolic outcomes following intravenous physiologic hormone administration to 10 Native Americans. We found reductions in hemoglobin A1C (baseline: 9.03% ± 2.08%, 6 months: 7.03% ± 0.73%, p = 0.008), fasting glucose (baseline: 176.0 ± 42.85 mg/dL, 6 months: 137.11 ± 17.05 mg/dL, p = 0.02), homeostatic model assessment of insulin resistance (baseline: 10.39 ± 4.66, 6 months: 7.74 ± 4.22, p = 0.008), and triglycerides (baseline: 212.20 ± 101.44, 6 months: 165.50 ± 76.48 mg/dL, p = 0.02). Physiologic hormone administration may improve components of the metabolic syndrome. The therapy warrants investigation in randomized controlled trials.
A new method for extracting conodonts and radiolarians from chert with NaOH solution
Authors: Rigo Manuel , Onoue Tetsuji , Wu Qiangwang , Tomimatsu Yuki , Santello Lisa , Du Yixing , Jin Xin , Bertinelli Angela
Published: August 2023

Microfossils are important components of sedimentary rocks used for palaeontological, biostratigraphic, palaeoenvironmental and palaeoclimatic investigations. They are usually extracted from rocks using an acid solution, which might vary depending on the embedding rock lithology. Here we propose a new method using common NaOH (sodium hydroxide; soda) to digest cherts (micro‐ and cryptocrystalline quartz) instead of the standard technique based on HF (hydrofluoric acid). This new method allows the collection of undamaged specimens of different kinds of microfossils, such as conodonts, radiolarians, teeth and dermal scales, the minerology of which is still preserved (e.g. biogenic apatite in conodonts). The use of soda is thus recommended, as it is less dangerous, less expensive, and it better preserves the extracted microfossils both in shape and mineralogy.
Why you should be a religious skeptic
Authors: Gäb Sebastian
Published: August 2023

Most philosophers of religion subscribe to some variety of religious realism: they believe that religious statements aim at capturing a mind‐independent reality and are true precisely if they successfully do so. Curiously, most religious realists also believe that at least some of our religious beliefs are rationally justified. In this paper, I argue that these positions are actually at odds with each other. Religious realists should rather be religious skeptics. I first argue that realism always implies the possibility of our beliefs being false. Then, I develop a Copernican argument to show that we have no reason to believe that we are in an epistemically privileged position where we could be confident that our particular belief is justified while all competing beliefs are not. This seems impossible for two reasons: (a) From a probabilistic point of view (adopting a principle of mediocrity), it is highly unlikely that current humans have the maximum of epistemic capacities possible. Rather, our ability to understand reality is limited, so we should expect at least some parts of religious reality to remain unknown to us. (b) From a deep‐time perspective, humanity has not pondered religious questions for long. We are probably still in the early stages of our cognitive evolution, and so we should treat our religious beliefs as provisional and open to revision.
High energy x-ray photoelectron spectroscopy (HAXPES) Cr Kα measurement of bulk chromium
Authors: Zborowski C. , Vanleenhove A. , Hoflijk I. , Vaesen I. , Artyushkova K. , Conard T.
Published: August 2023

Chromium was analyzed using high-resolution high energy x-ray photoelectron spectroscopy (HAXPES). The HAXPES spectra of chromium obtained using monochromatic Cr Kα radiation at 5414.8 eV include survey scan and high-resolution spectra of Cr 2s, Cr 2p, Cr 3s, and Cr 3p.
High energy x-ray photoelectron spectroscopy (HAXPES) Cr Kα measurement of bulk copper
Authors: Zborowski C. , Vanleenhove A. , Hoflijk I. , Vaesen I. , Artyushkova K. , Conard T.
Published: August 2023

Copper was analyzed using high-resolution high energy x-ray photoelectron spectroscopy (HAXPES). The HAXPES spectra of copper obtained using monochromatic Cr Kα radiation at 5414.8 eV include survey scan and high-resolution spectra of Cu 2s, Cu 2p3/2, Cu 3s, Cu 3p, Cu LMM, and Ar 1s.
Reformulation of frequency-difference matched-field processor for high-frequency known-source localization
Authors: Park Minseuk , Choo Youngmin , Choi Jongkwon , Lee Keunhwa
Published: August 2023

Frequency-difference matched-field processing is a high-frequency source localization technique formulated by matching the frequency-difference autoproduct of the measured field and replicas at the difference-frequency. Although it successfully localizes sound sources by sparse vertical array in shallow or deep ocean with an environmental mismatch, there is still some ambiguity in replica modeling and signal processing. Here, the existing conventional processor is modified to match the bandwidth-averaged autoproduct of the measured field with replicas of the bandwidth-averaged autoproduct, or approximately its self-term for the expected source locations. The proposed processor is consistent with the perspective of matched-field processing and can naturally relieve some drawbacks of the existing one, such as low peak or low dynamic range on the ambiguity surface. Numerical tests are carried out in several shallow ocean environments and the source localization using experimental data are performed to confirm the properties of the proposed processor. It is found that the high-frequency diffracted field always leaves traces on its bandwidth-averaged autoproduct field. These high-frequency marks cause a bias in source localization in the presence of a sound speed mismatch even in low difference-frequencies.
Predicting wideband real-ear-to-coupler differences in children using wideband acoustic immittance
Authors: McCreery Ryan W. , Grindle Anastasia , Merchant Gabrielle R. , Crukley Jeffery , Walker Elizabeth A.
Published: August 2023

Individual differences in ear-canal acoustics introduce variability into hearing aid output that can affect speech audibility. Measuring ear-canal acoustics in young children can be challenging, and relying on normative real-ear-to-coupler difference (RECD) transforms can lead to large fitting errors. Acoustic immittance measures characterize the impedance of the ear and are more easily measured than RECD. Using 226 Hz tympanometry to predict the RECD is more accurate than using age-based average RECD values. The current study sought to determine whether wideband acoustic immittance measurements could improve predictions of wideband real-ear-to-coupler difference (wRECD). 150 children ages 2–10 years with intact tympanic membranes underwent wRECD and wideband acoustic immittance measures in each ear. Three models were constructed to predict each child's measured wRECD: the age-based average wRECD, 226 Hz admittance wRECD, and wideband absorbance wRECD. The average age-based wRECD model predicted the child's measured wRECD within 3 dB in 62% of cases, but both the 226 Hz admittance and wideband absorbance wRECD were within 3 dB in 90% of cases. Using individual 226 Hz or wideband absorbance to predict wRECD improved the accuracy and precision of transforms used for pediatric hearing aid fitting.
Supplemental Material: Did subducted graphite fertilize the Franciscan mantle wedge with radiogenic Os?
Authors: Toma Jonathan , Creaser Robert A
Published: August 2023

Methods, petrographic descriptions, modeling, and data. 
Effects of intrinsic decoherence on quantum coherence and correlations between spins within a two-dimensional honeycomb lattice graphene layer system
Authors: Bouafia Zakaria , Elghaayda Samira , Mansour Mostafa
Published: August 2023

This research delves into the influence of intrinsic decoherence on the behavior of quantum correlations and coherence between two interacting qubits in a graphene-based system. To evaluate the amount of nonclassical correlations in the system, we employ local quantum uncertainty (LQU), and to assess quantum coherence we use the relative entropy of coherence [Formula: see text] and [Formula: see text]-norm [Formula: see text]. We assume that the system is initially prepared in an extended-Werner-like (EWL) state, and we investigate how these quantifiers evolve over time and examine their sensitivity to various graphene layer system parameters, mixture parameter of the initial state and the intrinsic decoherence rate. Our results indicate that by adjusting the wave number operators, decreasing the intrinsic decoherence rate, and increasing the initial state mixing parameter, it is possible to enhance both quantum correlations and coherence within the two-dimensional honeycomb lattice system. In addition, we found that quantum coherence is more resilient to intrinsic decoherence than LQU, moreover, the [Formula: see text]-norm is more robust than the relative entropy of coherence.
Dynamical evolution of three-state spin-1 non-Hermitian system with Cayley–Hamilton theorem
Authors: Salah Ahmed , Marrouf A. A. , Khedr M.
Published: August 2023

In this paper, we study the time evolution of three-states spin-1 non-Hermitian systems. The state vector of the wave function for Schrödinger equation is obtained analytically by using the Cayley–Hamilton theorem. We note that the behavior of the non-Hermitian three-states system corresponds to the Hermitian three-state system. Furthermore, the fluctuation between three-state spin-1 is periodically oscillating when the eigenvalues of the non-Hermitian system are real. Moreover, if the eigenvalues are imaginary, we explore that from our analysis and analytical solution that the probabilities’ amplitudes always grow with time for all physical parameters in the three-state, i.e. including the [Formula: see text]-symmetry non-Hermitian system. It means that the Schrödinger equation becomes the growth exponential.
Mechanism of heat transfer in Falkner–Skan flow of buoyancy-driven dissipative hybrid nanofluid over a vertical permeable wedge with varying wall temperature
Authors: Panda Subhajit , Ontela Surender , Thumma Thirupathi , Mishra S. R. , Pattnaik P. K.
Published: August 2023

Heat transport issues of wedge-shaped flow on hybrid nanofluids are of special significance by reason of their importance in manufacturing uses including heat exchangers solar panels, electronic equipment cooling, drying processes, and air heaters. Consequently, the current investigation investigates the behavior of dissipative Single-walled Carbone nanotubes (SWCNT) — Multi-walled Carbon nanotubes (MWCNT) hybrid nanofluid in the buoyant flow towards a radiative vertical permeable wedge subjected to variable wall temperature considering heat source/sink. By selecting appropriate similarity conversions, the resultant flow regulating nonlinear boundary layer PDEs are subsequently transformed into coupled nonlinear ODEs. After that, the boundary layer Boussinesq approximations are numerically resolved. The significant outcome of the current investigation is the heat transport which is higher for linear radiation, volume fraction, and uniform heat source parameters. The momentum is controlled with wedge angle and volume fraction of nanotube particles. The momentum boundary layer is upsurged with mixed convection parameters for an assisting flow. Changes to the Nusselt number and fluid flow rate are measured for flow-controlling parameters. Furthermore, the results are compared and effectively validated with previously reported literature results.
Understanding the influence of physical parameters on the dielectric characteristics of Bi-MXene lattice through Monte Carlo simulations
Authors: Fadil Z. , Raorane Chaitany Jayprakash , El Fdil R. , Karam Steve , Rahaman Mostafizur , Rosaiah P. , Kim Seong Cheol
Published: August 2023

This paper presents a study on the dielectric characteristics of the Bi-MXene lattice using Monte Carlo simulations through the Metropolis algorithm. The study utilizes the Blume–Capel Ising model to analyze the dielectric characteristics under the effects of temperature, ferrielectric parameter, and external electric longitudinal and crystalline fields. Also, it examines the impact of the ferrielectric parameter [Formula: see text], the external electric field ([Formula: see text], and the crystalline field on the behavior of the blocking temperature ([Formula: see text]. The results suggest a significant influence of the physical parameters on the blocking temperature analyzed in this study. Additionally, these findings hold implications on ferrielectric materials.
A Collaborative Learning-based Urban Low-light Small-target Face Image Enhancement Method
Authors: Wu Zheng , Guo Kehua , Wang Liwei , Hu Min , Ren Sheng
Published: August 2023

Face recognition is an essential technology in intelligent transportation and security within smart cities. Nevertheless, face images taken in nighttime urban environments often suffer from low brightness, small sizes, and low resolution, which pose significant challenges for accurate face feature recognition. To address this issue, we propose the Low-light Small-target Face Enhancement (LSFE) method, a collaborative learning-based image brightness enhancement approach specifically designed for small-target faces in low-light environments. LSFE employs a multilevel feature stratification module to acquire detailed face image features at different levels, revealing hidden facial image information within the dark. In addition, we design a network combining collaborative learning and self-attention mechanisms, which effectively captures long-distance pixel dependencies in low-brightness face images and enhances their brightness in a stepwise manner. The enhanced feature maps are then fused through a branch fusion module. Experimental results demonstrate that LSFE can more effectively enhance the luminance of small-target face images in low-light scenes while retaining more visual information, compared to other existing methods.
Carbon Monoxide Poisoning: From Microbes to Therapeutics
Authors: Dent Matthew R. , Rose Jason J. , Tejero Jesús , Gladwin Mark T.
Published: August 2023

Carbon monoxide (CO) poisoning leads to 50,000–100,000 emergency room visits and 1,500–2,000 deaths each year in the United States alone. Even with treatment, survivors often suffer from long-term cardiac and neurocognitive deficits, highlighting a clear unmet medical need for novel therapeutic strategies that reduce morbidity and mortality associated with CO poisoning. This review examines the prevalence and impact of CO poisoning and pathophysiology in humans and highlights recent advances in therapeutic strategies that accelerate CO clearance and mitigate toxicity. We focus on recent developments of high-affinity molecules that take advantage of the uniquely strong interaction between CO and heme to selectively bind and sequester CO in preclinical models. These scavengers, which employ heme-binding scaffolds ranging from organic small molecules to hemoproteins derived from humans and potentially even microorganisms, show promise as field-deployable antidotes that may rapidly accelerate CO clearance and improve outcomes for survivors of acute CO poisoning.
Impella-Supported Optical Coherence Tomography-Guided Aggressive Rotational Atherectomy for Heavily Calcified Lesions in Left Main Trunk Bifurcation in a Patient with Severe Left Ventricular Systolic Dysfunction
Authors: Koide Masahiro , Fukui Kento , Sugimoto Hikaru , Takeda Yuki , Sogabe Koji , Kato Yukinori , Kitajima Hiroki , Akabame Satoshi
Published: August 2023

The Impella, a percutaneous left ventricular assist device, has been reported to minimize the risk of hemodynamic compromise and improve clinical outcomes during percutaneous coronary intervention (PCI) in complex high-risk indicated patients (CHIPs). Optical coherence tomography (OCT) provides information on calcified plaque thickness, which is helpful in determining the indication and endpoint of atherectomy during PCI for calcified lesions. However, there are few reports on OCT-guided aggressive rotational atherectomy with Impella assistance in CHIPs. A 71-year-old man on dialysis for end-stage renal failure was admitted for congestive heart failure. Transthoracic echocardiography revealed severe left ventricular systolic dysfunction, and coronary angiography performed after improvement of heart failure showed severe stenosis with heavily calcified lesions in the left main trunk (LMT) bifurcation and right coronary artery. The patient refused coronary artery bypass surgery and was revascularized using PCI. PCI was started with prophylactic Impella CP insertion because of the high risk of hemodynamic collapse. After OCT-guided rotational atherectomy with 1.5- and 2.0-mm burr toward the left anterior descending artery and left circumflex artery, respectively, double-kissing culotte stenting was performed in the LMT, and good dilation was obtained. Impella CP was removed immediately after PCI without hemodynamic compromise, and the procedure was completed.
Table S7 from Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Authors: Fan Fanfan , Gao Jian , Zhao Yue , Wang Jun , Meng Lu , Ma Jiaqiang , Li Teng , Han Han , Lai Jinglei , Gao Zhendong , Li Xiongfei , Guo Ran , Cao Zhiwei , Zhang Yang , Zhang Xiaoming , Chen Haiquan
Published: August 2023

Table S7
Table S5 from Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Authors: Fan Fanfan , Gao Jian , Zhao Yue , Wang Jun , Meng Lu , Ma Jiaqiang , Li Teng , Han Han , Lai Jinglei , Gao Zhendong , Li Xiongfei , Guo Ran , Cao Zhiwei , Zhang Yang , Zhang Xiaoming , Chen Haiquan
Published: August 2023

Table S5
Table S4 from Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Authors: Fan Fanfan , Gao Jian , Zhao Yue , Wang Jun , Meng Lu , Ma Jiaqiang , Li Teng , Han Han , Lai Jinglei , Gao Zhendong , Li Xiongfei , Guo Ran , Cao Zhiwei , Zhang Yang , Zhang Xiaoming , Chen Haiquan
Published: August 2023

Table S4
Supplementary Material from Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Authors: Fan Fanfan , Gao Jian , Zhao Yue , Wang Jun , Meng Lu , Ma Jiaqiang , Li Teng , Han Han , Lai Jinglei , Gao Zhendong , Li Xiongfei , Guo Ran , Cao Zhiwei , Zhang Yang , Zhang Xiaoming , Chen Haiquan
Published: August 2023

Supplementary Material
Supplementary Data from Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma
Authors: Sekiya Sho , Fukuda Junki , Yamamura Ryodai , Ooshio Takako , Satoh Yusuke , Kosuge Shinya , Sato Reo , Hatanaka Kanako C. , Hatanaka Yutaka , Mitsuhashi Tomoko , Nakamura Toru , Matsuno Yoshihiro , Hirano Satoshi , Sonoshita Masahiro
Published: August 2023

Supplementary methods, tables, and figures
Supplementary Table 2 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Authors: Chen Chen , Shin June Ho , Fang Zhuoqing , Brennan Kevin , Horowitz Nina B. , Pfaff Kathleen L. , Welsh Emma L. , Rodig Scott J. , Gevaert Olivier , Gozani Or , Uppaluri Ravindra , Sunwoo John B.
Published: August 2023

Sequences
Supplementary Table 1 from Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma
Authors: Chen Chen , Shin June Ho , Fang Zhuoqing , Brennan Kevin , Horowitz Nina B. , Pfaff Kathleen L. , Welsh Emma L. , Rodig Scott J. , Gevaert Olivier , Gozani Or , Uppaluri Ravindra , Sunwoo John B.
Published: August 2023

Antibodies used
Supplementary Table S5 from The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
Authors: Li Zheqi , Li Tianqin , Yates Megan E. , Wu Yang , Ferber Amanda , Chen Lyuqin , Brown Daniel D. , Carroll Jason S. , Sikora Matthew J. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: August 2023

Overall data set and experiments included in the EstroGene database
Supplementary Table S11 from The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
Authors: Li Zheqi , Li Tianqin , Yates Megan E. , Wu Yang , Ferber Amanda , Chen Lyuqin , Brown Daniel D. , Carroll Jason S. , Sikora Matthew J. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: August 2023

LISA regulator predictions of all signatures
Supplementary Table S10 from The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer
Authors: Li Zheqi , Li Tianqin , Yates Megan E. , Wu Yang , Ferber Amanda , Chen Lyuqin , Brown Daniel D. , Carroll Jason S. , Sikora Matthew J. , Tseng George C. , Oesterreich Steffi , Lee Adrian V.
Published: August 2023

EstroGene temporal, contextual and directional signatures
Supplementary Data from Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma
Authors: Rohila Deepak , Park In Hwan , Pham Timothy V. , Weitz Jonathan , Hurtado de Mendoza Tatiana , Madheswaran Suresh , Ishfaq Mehreen , Beaman Cooper , Tapia Elisabette , Sun Siming , Patel Jay , Tamayo Pablo , Lowy Andrew M. , Joshi Shweta
Published: August 2023

Supplementary table
Supplementary Figure 6. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

Gene expression level of CHD7 among the mCRPC tumors of Beltran et al. cohort
Supplementary Figure 5. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

Gene expression level of SOX2 among the tumor subtypes of WCDT samples
Supplementary Figure 1. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

Hierarchical clustering and principal component analyses (PCA) on the mCRPC tumors of WCDT cohort.
Supplementary Data 2. from The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Authors: Lundberg Arian , Zhang Meng , Aggarwal Rahul , Li Haolong , Zhang Li , Foye Adam , Sjöström Martin , Chou Jonathan , Chang Kevin , Moreno-Rodriguez Thaidy , Shrestha Raunak , Baskin Avi , Zhu Xiaolin , Weinstein Alana S. , Younger Noah , Alumkal Joshi J. , Beer Tomasz M. , Chi Kim N. , Evans Christopher P. , Gleave Martin , Lara Primo N. , Reiter Rob E. , Rettig Matthew B. , Witte Owen N. , Wyatt Alexander W. , Feng Felix Y. , Small Eric J. , Quigley David A.
Published: August 2023

List of enriched motifs identified in the hyper- and hypo-methylated regions of mCRPC subtypes
Movie S4 from Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics
Authors: Gallaher Jill , Strobl Maximilian , West Jeffrey , Gatenby Robert , Zhang Jingsong , Robertson-Tessi Mark , Anderson Alexander R.A.
Published: August 2023

Movies corresponding to simulation examples in Figure 6, comparing continuous and adaptive therapy for simulations with intermetastasis and intrametastasis heterogeneity.
Figure S9 from BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non–Small Cell Lung Cancer
Authors: Lim Sun Min , Fujino Toshio , Kim Chulwon , Lee Gwanghee , Lee Yong-Hee , Kim Dong-Wan , Ahn Jin Seok , Mitsudomi Tetsuya , Jin Taiguang , Lee Sang-Yoon
Published: August 2023

Supplementary Figure 9. Circulating tumor DNA analysis data from Case 2. A, Allelic configuration of T790M (red), L792H (green) and C797S (blue). B, Serial changes in allelic frequency of mutations detected in blood. C, Concentration-response curves and IC50 values of BBT-176 for EGFR 19Del/T790M/L792H mutant kinase.
Supplementary Methods S1 from B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy
Authors: Woyach Jennifer A. , Ghia Paolo , Byrd John C. , Ahn Inhye E. , Moreno Carol , O'Brien Susan M. , Jones Daniel , Cheung Leo W.K. , Chong Elizabeth , Kwei Kevin , Dean James P. , James Danelle F. , Wiestner Adrian
Published: August 2023

Supplemental methods discussing mutation testing.
Figure S8 from BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non–Small Cell Lung Cancer
Authors: Lim Sun Min , Fujino Toshio , Kim Chulwon , Lee Gwanghee , Lee Yong-Hee , Kim Dong-Wan , Ahn Jin Seok , Mitsudomi Tetsuya , Jin Taiguang , Lee Sang-Yoon
Published: August 2023

Supplementary Figure 8. Circulating tumor DNA analysis data from Case 1. A, Allelic configuration analysis by liquid biopsy confirmed cis relationship between EGFR T790M and C797S mutations; no trans clones were detected. B, Serial changes in allelic frequency of all mutations detected in blood.
Supplementary Data 1 from Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients
Authors: Paweletz Cloud P. , Heavey Grace A. , Kuang Yanan , Durlacher Emily , Kheoh Thian , Chao Richard C. , Spira Alexander I. , Leventakos Konstantinos , Johnson Melissa L. , Ou Sai-Hong Ignatius , Riely Gregory J. , Anderes Kenna , Yang Wenjing , Christensen James G. , Jänne Pasi A.
Published: August 2023

Demographics and Baseline Characteristics
Supplemental Figure 1 from Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients
Authors: Paweletz Cloud P. , Heavey Grace A. , Kuang Yanan , Durlacher Emily , Kheoh Thian , Chao Richard C. , Spira Alexander I. , Leventakos Konstantinos , Johnson Melissa L. , Ou Sai-Hong Ignatius , Riely Gregory J. , Anderes Kenna , Yang Wenjing , Christensen James G. , Jänne Pasi A.
Published: August 2023

Supplemental Figure 1: Quantitative concordance between NGS and ddPCR KRASG12C results.ctDNA, circulating tumor DNA; ddPCR, droplet digital polymerase chain reaction.
Supplementary Table S7 from Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Authors: Rotow Julia , Patel Jyoti D. , Hanley Matthew P. , Yu Helena , Awad Mark , Goldman Jonathan W. , Nechushtan Hovav , Scheffler Matthias , Kuo Chih-Hsi S. , Rajappa Senthil , Harada Guilherme , Clifford Sarah , Santucci Alison , Silva Laura , Tupper Rebecca , Oxnard Geoffrey R. , Kherani Jennifer , Drilon Alexander
Published: August 2023

Response to combination therapy
Supplementary Table S5 from Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Authors: Rotow Julia , Patel Jyoti D. , Hanley Matthew P. , Yu Helena , Awad Mark , Goldman Jonathan W. , Nechushtan Hovav , Scheffler Matthias , Kuo Chih-Hsi S. , Rajappa Senthil , Harada Guilherme , Clifford Sarah , Santucci Alison , Silva Laura , Tupper Rebecca , Oxnard Geoffrey R. , Kherani Jennifer , Drilon Alexander
Published: August 2023

Dose modification
Supplementary Table S3 from Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Authors: Rotow Julia , Patel Jyoti D. , Hanley Matthew P. , Yu Helena , Awad Mark , Goldman Jonathan W. , Nechushtan Hovav , Scheffler Matthias , Kuo Chih-Hsi S. , Rajappa Senthil , Harada Guilherme , Clifford Sarah , Santucci Alison , Silva Laura , Tupper Rebecca , Oxnard Geoffrey R. , Kherani Jennifer , Drilon Alexander
Published: August 2023

Combination therapy dosing
Supplementary Table S1 from Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Authors: Rotow Julia , Patel Jyoti D. , Hanley Matthew P. , Yu Helena , Awad Mark , Goldman Jonathan W. , Nechushtan Hovav , Scheffler Matthias , Kuo Chih-Hsi S. , Rajappa Senthil , Harada Guilherme , Clifford Sarah , Santucci Alison , Silva Laura , Tupper Rebecca , Oxnard Geoffrey R. , Kherani Jennifer , Drilon Alexander
Published: August 2023

Enrollment assay
Supplementary Table S1 from Patient-Reported Outcomes as Interradiographic Predictors of Response in Non–Small Cell Lung Cancer
Authors: Bhatt Ambika S. , Schabath Matthew B. , Hoogland Aasha I. , Jim Heather S.L. , Brady-Nicholls Renee
Published: August 2023

Patient demographics table
Supplementary Table 1 from Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia
Authors: Saygin Caner , Giordano Giorgia , Shimamoto Kathryn , Eisfelder Bart , Thomas-Toth Anika , Venkataraman Girish , Ananthanarayanan Vijayalakshmi , Vincent Tiffaney L. , DuVall Adam , Patel Anand A. , Chen Yi , Tan Fenlai , Anthony Stephen P. , Chen Yu , Shen Yue , Odenike Olatoyosi , Teachey David T. , Kee Barbara L. , LaBelle James , Stock Wendy
Published: August 2023

Supplementary Table