bluuebunny/crossref_metadata_2025 huggingface dataset:
Graphite to diamond-like carbon phase transformation by high-pressure torsion
Authors: Edalati Kaveh , Daio Takeshi , Ikoma Yoshifumi , Arita Makoto , Horita Zenji
Published: July 2013

Diamond-like carbon (DLC) with significant fraction of tetrahedral sp3 bonds and amorphous structure is generally produced in the form of thin films by rapid cooling of high-energy carbon atoms in vacuum. This study shows that DLC can be directly formed from bulk samples of graphite by application of severe plastic deformation under high pressures. The formation of DLC is enhanced with increasing the shear strain, pressure, and temperature. It is suggested that the high pressure thermodynamically stabilize DLC and formation of high density of lattice defects by straining reduces the energy barrier for DLC formation.
Beltrami fields at nanoscales in a quantum electron-hole plasma
Authors: Iqbal M.
Published: July 2013

The self-organization of electron-hole quantum plasmas is described. It is shown that steady state equilibrium is governed by a triple curl Beltrami field which is a superposition of three Beltrami fields. The results show the possibility of creating Beltrami fields of the order of nanoscale size. It is also shown that pressure gradients exist in the relaxed state and can be confined by a generalized Bernoulli mechanism. Our results are of strong relevance to quantum nano devices.
High-selectivity imaging of closed cracks using elastic waves with thermal stress induced by global preheating and local cooling
Authors: Ohara Yoshikazu , Takahashi Koji , Murai Satoru , Yamanaka Kazushi
Published: July 2013

The authors developed a practical method based on the thermal stress dependence of cracks for the accurate imaging of closed cracks with high selectivity. A tightly closed fatigue crack was visualized in linear phased array (PA) images by opening the crack with the tensile thermal stress induced by global preheating and local cooling (GPLC), although the conventional method of using only local cooling could not fully open the crack. Furthermore, by the subtraction of the PA images before and after GPLC, only the closed crack was extracted with high selectivity while canceling the other linear scatterers.
Oxygen-induced bi-modal failure phenomenon in SiOx-based resistive switching memory
Authors: Chang Yao-Feng , Ji Li , Wu Zhuo-Jie , Zhou Fei , Wang Yanzhen , Xue Fei , Fowler Burt , Yu Edward T. , Ho Paul S. , Lee Jack C.
Published: July 2013

The ambient gas effect in SiOx-based resistive switching memory has been studied. After the electroforming process, resistive switching behavior functions in vacuum as well as in nitrogen without dramatic degradation. However, introducing an oxygen-nitrogen ambient suppresses resistive switching behavior at pressures above 1 Torr. Resistive switching is fully reestablished in oxygen-exposed devices after a vacuum recovery step. The failure phenomena can be described by Monte Carlo simulation using bi-modal statistics to enable feature distribution modeling of failure modes. Design criteria and guidelines are identified for packaging of future oxygen-sensor and of nonvolatile memory applications.
Isotachophoresis with emulsions
Authors: Goet G. , Baier T. , Hardt S. , Sen A. K.
Published: July 2013

An experimental study on isotachophoresis (ITP) in which an emulsion is used as leading electrolyte (LE) is reported. The study aims at giving an overview about the transport and flow phenomena occurring in that context. Generally, it is observed that the oil droplets initially dispersed in the LE are collected at the ITP transition zone and advected along with it. The detailed behavior at the transition zone depends on whether or not surfactants (polyvinylpyrrolidon, PVP) are added to the electrolytes. In a system without surfactants, coalescence is observed between the droplets collected at the ITP transition zone. After having achieved a certain size, the droplets merge with the channel walls, leaving an oil film behind. In systems with PVP, coalescence is largely suppressed and no merging of droplets with the channel walls is observed. Instead, at the ITP transition zone, a droplet agglomerate of increasing size is formed. In the initial stages of the ITP experiments, two counter rotating vortices are formed inside the terminating electrolyte. The vortex formation is qualitatively explained based on a hydrodynamic instability triggered by fluctuations of the number density of oil droplets.
Investigation of the effect of low energy ion beam irradiation on mono-layer graphene
Authors: Xu Yijun , Zhang Kun , Brüsewitz Christoph , Wu Xuemei , Hofsäss Hans Christian
Published: July 2013

In this paper, the effect of low energy irradiation on mono-layer graphene was studied. Mono-layer graphene films were irradiated with B, N and F ions at different energy and fluence. X-ray photoelectron spectroscopy indicates that foreign ions implanted at ion energies below 35 eV could dope into the graphene lattice and form new chemical bonds with carbon atoms. The results of Raman measurement indicate that ion beam irradiation causes defects and disorder to the graphene crystal structure, and the level of defects increases with increasing of ion energy and fluence. Surface morphology images also prove that ion beam irradiation creates damages to graphene film. The experiment results suggest that low-energy irradiation with energies of about 30 eV and fluences up to 5·1014 cm−2 could realize small amount of doping, while introducing weak damage to graphene. Low energy ion beam irradiation, provides a promising approach for controlled doping of graphene.
Light emission from thulium silicates and oxides for optical amplifiers on silicon in the extended optical communications band
Authors: Omi Hiroo , Hagiwara Atsushi , Tawara Takehiko
Published: July 2013

Films composed of Tm2Si2O7 and Tm2O3 grains formed on SiO2/Si substrates by radio magnetic sputtering and subsequent thermal annealing up to 1250 °C were characterized by synchrotron grazing incidence X-ray diffraction, cross-sectional transmission microscopy, and micro photoluminescence (PL) measurements. The films composed of triclinic (type-B) and monoclinic (type-C) Tm2Si2O7 grains on SiO2/Si and Tm2O3 grains on Si exhibit photoluminescence at the wavelength of about 1620 nm for the silicates and 1630 nm for the oxide, which indicates that they have good potential as light amplifiers on Si in the L and U bands at telecommunications wavelengths.
For Polanyian Economic Geographies
Authors: Peck Jamie
Published: July 2013

Karl Polanyi has been an influential but also somewhat elusive figure in economic geography. Best known for his evocative notion of social embeddedness, it is perhaps fitting that Polanyi's presence has been more metaphorical than substantive. The paper asks what a more engaged Polanyian economic geography might look like. Focusing on methodological affinities, a response is developed in terms of a commitment to the substantivist (as opposed to formal) analysis of actually existing economic formations, together with a more purposive embrace of institutionalism, holism, and comparativism.
Men and Things: Karl Polanyi, Primitive Accumulation, and Their Relevance to a Radical Green Political Economy
Authors: Prudham Scott
Published: July 2013

Now is an important moment to be thinking and talking about a critical and normative green political economy. Whether via attempts to develop effective and socially just climate policies at multiple scales of governance [including REDD (reducing emissions from deforestation and degradation) schemes], or to develop proliferating and controversial neoliberal instruments for dealing with undesirable environmental change, environmental governance, and environmental change in the context of contemporary global capitalism are on the agenda. What would a critical and normative green political economy for the current moment look like? This paper draws on Karl Polanyi's The Great Transformation as a resource for answering that question. In particular, Polanyi's discussion of problematic and dualistic notions of nature and society in early political economy and the role he accords social struggles over land in developing his theory of fictitious commodities, embeddedness and the double movement are revisited. The paper stresses how Polanyi's ideas, at once conceptual and polemical, draw centrally on Marx's theorization of primitive accumulation as an inherent, ‘extra-economic’ facet of historical—geographical capitalism, a differentiated unity linking the commodification and objectification of human and nonhuman natures as exchange-values. In this respect, Polanyi offers (or seems to offer) a potential reconciliation of a politics of nonhuman and human nature through his emphasis on primitive accumulation as a site of both political struggle and epistemic transformation.
Is Environmental Management Really More Collaborative? A Comparative Analysis of Putative ‘Paradigm Shifts’ in Europe, Australia, and the United States
Authors: Benson David , Jordan Andrew , Smith Laurence
Published: July 2013

It is a truism that environmental management has experienced a significant change in the locus of governing, in which centralised forms of steering have been gradually replaced by more collaborative management approaches organised at the ecosystem scale. Whereas much research capital has been expended on informing their design and promoting their uptake, surprisingly little systematic comparative empirical research exists on the precise nature and extent of what is often described as a ‘paradigm shift’ in governing. We address this gap by examining how one issue often deemed to require deeper ‘collaboration’, namely, catchment management, has been addressed in three comparable federal political systems: the European Union; the USA; and Australia. On the basis of a fresh and more comparable account of the forms and modalities of collaboration, we reveal that, although collaboration has undoubtedly grown in recent decades, its depth and extent remains highly variable both across and within the three cases. We also examine what these subtly different geographical ‘contours of collaboration’ imply for future research and practice.
Institutional Mobility and Mutation in the Global Capitalist System: A Neo-Polanyian Analysis of a Transnational Cotton Standards War, 1870–1945
Authors: Quark Amy A
Published: July 2013

This paper explores the dynamics of institutional change in periods of instability in the global capitalist system. Two recent bodies of literature—actor-centered institutionalism and the ‘policy mobilities’ approach—emphasize how contextual and historical specificities drive transformation as institutions move across space. However, scholars in both traditions give less attention to the systematic patterns of social conflict that influence how policies move and mutate. Drawing on the case of a standards war in the global cotton trade from 1870 to 1945, I build on these literatures by linking them to a neo-Polanyian theory of social conflict within periods of market-led development. From this view, we must understand institutions, their mobilities, and mutations as constituted by and constitutive of struggles over how the global capitalist system should be organized and in whose interests. This requires building on, but also deepening Polanyi's analysis. While Polanyi emphasized the destructive effects of liberal market projects that generate social conflict, the ‘push-backs’ against liberal market projects are more diverse than Polanyi suggested, and social conflict can also emerge out of the creative moments of liberal market expansion.
Marketization beyond Neoliberalization: A Neo-Polanyian Perspective on China's Transition to a Market Economy
Authors: Zhang Jun
Published: July 2013

This paper proposes a neo-Polanyian framework of neoliberalization-as-marketization for understanding geohistorically embedded marketization based on five interlinked theoretical conceptualizations: embedded marketization, hybrid integration, double movement, active society, and qualitative state. I argue that this framework can be useful to supplement existing theorizing of neoliberalism, and to facilitate comparative case studies across vastly differently contexts. This framework is then taken to analyze China's post-Mao transition to a market economy. I argue that China's gradualist transition from a centrally planned economy to a mixed economy has been maneuvered by a self-regulating party-state (dis)embedded in a deactivated (active) society. Due to the existence of multiple veto players and intraparty ‘double movement’, the marketization was able to be mostly socially progressive until 1993. However, it was no longer the case when the ‘socialist market economy’ was enshrined and, without political liberalization, the Chinese version of neoliberalization has become even bleaker than elsewhere.
Disembedding Polanyi: Exploring Polanyian Economic Geographies
Authors: Peck Jamie
Published: July 2013

The paper provides an introduction to a theme issue devoted to the influence—and the potential—of the work of Karl Polanyi in the field of economic geography. Polanyi has been an inspirational figure in the heterodox field of ‘socioeconomics’, where the inseparability of the economic and the social is taken to be axiomatic. He has also made recurrent appearances in economic geography since the early 1990s, as a progenitor of the ‘networks and embeddedness’ approach and in his role as a prescient critic of market fundamentalism. But the potential of Polanyian approaches in economic geography has only been fitfully explored. In this context, the contributions to this theme issue make the case for a more sustained—but also open, critical, and creative—engagement with Polanyi's legacy.
Flush development in Tahitian lime
Authors: Olesen Trevor , Smith Glenn , Muldoon Steven J.
Published: July 2013

The relationship between the cycle of flush development and temperature is not well described for Tahitian lime, or citrus species in general. We pruned trees over 16 months in the humid subtropics of northern New South Wales (NSW), and monitored post-pruning flush development over two cycles, in terms of flush commencement and flowering. We also recorded temperatures over this period. The time from pruning to the emergence of the first post-pruning flush was correlated with mean daily temperature, with emergence being slower at cooler temperatures. Emergence times ranged from 11 to 39 days. The time between the commencement of the first and second flushes was also correlated with mean daily temperature, with slower development of the first flush at cooler temperatures. The duration of the first flush varied from 41 to 128 days. There was more flowering on the first than the second flush (16% of shoots versus 3%). There was no flowering on flushes that commenced in the warmer months, from November to March. The temperature threshold for flowering appeared to be at a mean daily temperature of ~20°C. Regressions between flush development and temperature were used to estimate the effects of climate warming from 1963–1971 to 2003–2011, using long-term temperature records. The warming decreased bud emergence time by 1.6 days in winter and 1 day in summer; and reduced the time from the first to the second flush by 11.8 days in winter and 9.2 days in summer. The results for Tahitian lime were similar to those for other recurrent flushing trees.
Physiological response of halophytes to multiple stresses
Authors: Hamed Karim Ben , Ellouzi Hasna , Talbi Ons Zribi , Hessini Kamel , Slama Ines , Ghnaya Taher , Bosch Sergi Munné , Savouré Arnould , Abdelly Chedly
Published: July 2013

As halophytes grow vigorously in saline soils, they serve as extraordinary resources for the identification and development of new crop systems. Understanding the mechanisms of tolerance of halophytes to salinity in combination with other co-occurring constraints such as drought, flooding, heavy metals and nutrient deficiencies, would facilitate efforts to use halophytes for saline land revegetation, as well as provide new insights that might be considered in future breeding of plants for salt-affected agricultural lands. Recent results suggest that salinity may improve the response of halophytes to other stresses. Some physiological and biochemical mechanisms of tolerance to salinity are common to many halophytes when plants are subjected to salinity, whereas others are specifically amplified under a combination of stresses. Therefore, the response of halophytes to multiple stresses may not reflect an additive effect of these constraints, but rather, constitute specific response to a new situation where many constraints are operating simultaneously. Comparative studies between halophytes and glycophytes have shown that halophytes are better equipped with the mechanisms of cross-stress tolerance and are constitutively prepared for stress. Moreover, other data has shown that the pre-treatment of halophytes with salinity or other constraints in the early stages of development improves their subsequent response to salinity, which suggests the capacity of these plants to ‘memorise’ a previous stress allows them respond positively to subsequent stress.
The Emergence of Political Parties and Political Dynamics in Afghanistan, 1964–73
Authors: Bezhan Faridullah
Published: July 2013

The 1960s in Afghanistan's history were marked by the emergence of a number of political parties, from monarchist to radical left and right. They played an important role in the social, cultural and political dynamics of the time and even the future of the country. This paper explores how political parties emerged in a country which was characterized as a tribal-peasant society with only a very small number of educated people. It also discusses why the monarch would not sign the Political Parties' Bill and how this influenced Afghanistan's political culture and led to the radicalization of the political parties. In addition, it examines how the anti-government and radical political parties managed to mobilize people and dominate the political scene while the pro-government and nationalist parties had little influence.
Edwardsiellosis Caused by Edwardsiella ictaluri in Laboratory Populations of Zebrafish Danio rerio
Authors: Hawke John P. , Kent Michael , Rogge Matt , Baumgartner Wes , Wiles Judy , Shelley Johnny , Savolainen L. Christine , Wagner Robert , Murray Katy , Peterson Tracy S.
Published: July 2013

We report the first cases of Edwardsiella ictaluri causing epizootics in laboratory populations of Zebrafish Danio rerio. Edwardsiella ictaluri is primarily recognized as a disease of catfish species and is known to cause an economically important bacterial disease of farm-raised catfish in the USA and abroad; however, it has been isolated on occasion from 10 other genera of nonictalurid fishes. We isolated E. ictaluri from moribund Zebrafish held in quarantine at two different universities in two states and from a research facility in a third state between February 23 and December 6, 2011. Edwardsiellosis in Zebrafish can be described as a severe systemic disease characterized by tissue necrosis and the presence of large numbers of extracellular and intracellular bacteria, often within macrophages. The kidneys (pronephros and mesonephros), spleen, nares, and forebrain were the most commonly and severely affected tissues. In outbreaks, mortality was acute and numerous fish died over a 1–2 week period. Mortality continued until the majority of the population was lost, at which time the remaining fish were euthanized. In addition to these cases, four cultures of bacteria isolated from Zebrafish by another diagnostic laboratory were submitted to the Louisiana Aquatic Diagnostic Laboratory for identification and were confirmed as E. ictaluri. In total, eight cultures of E. ictaluri from Zebrafish from Louisiana, Massachusetts, Pennsylvania, and Florida were identified. The isolates were confirmed as E. ictaluri by biochemical phenotype, API 20E (bioMérieux), and amplification and sequencing of a portion of the 16S rRNA gene. Edwardsiella ictaluri isolates from Zebrafish are believed to comprise a unique group and were differentiated from catfish isolates by exhibiting weaker motility, autoaggregation in broth, a different plasmid profile (two plasmids of 4.0 and 3.5 kb), a different API 20E code (4204000), and lack of lipopolysaccharide recognition with Mab Ed9.

Received November 9, 2012; accepted February 22, 2013
Peace and Pollution: An Examination of Palestinian—Israeli Trans-Boundary Hazardous Waste Management 20 Years after the Oslo Peace Accords
Authors: Alleson Ilan , Levin Jamie , Brenner Shmuel , Al Hmaidi Mohammad Said
Published: July 2013

As part of the Oslo Accords, Israel and the Palestinian Authority agreed to jointly manage issues of environmental concern according to internationally recognised standards. The purpose of this paper is to qualitatively evaluate the outcomes of the Palestinian–Israeli Oslo environmental peace agreements regarding trans-boundary hazardous waste management. Hazardous waste is an area of particular importance given the potential for inefficient management to impact on public health and shared ecological resources. Although the environmental negotiations that took place within the framework of the Oslo Accords can be seen as a significant milestone for environmental cooperation, many objectives were never achieved. Ultimately, both parties were left with suboptimal trans-boundary management, in practice, because broader political disputes derailed cooperation in many technical spheres. This outcome can be attributed to four main factors: Israeli security concerns, territorial disputes, logistical ambiguities and Palestinian institutional constraints. The outcomes of the environmental agreements challenge neo-functionalist approaches to peacebuilding at the inter-state level. Given the risks environmental concerns pose to both sides, new models are needed that disentangle the management of immediately shared environmental challenges from the ongoing conflict.
Nigeria's Amnesty Programme as a Peacebuilding Infrastructure: A Silver Bullet?
Authors: Ushie Vanessa
Published: July 2013

This paper offers a critical account of the amnesty programme introduced by the Nigerian state in 2009. It examines the impact and limitations of the amnesty as an instrument of peacebuilding, and emphasises the need for wider reforms that address underdevelopment and poverty in the Niger Delta region. The paper argues that the amnesty programme is a laudable effort but is by no means a silver bullet. It is better understood as a specific response to a resource-driven conflict that requires a broader, comprehensive resolution.
The Prevalence of Violence in Post-Conflict Societies: A Case Study of Kwazulu-Natal, South Africa
Authors: Schuld Maria
Published: July 2013

After war — so the common definition suggests — comes peace. Recent research, however, shows that post-conflict societies sometimes experience levels of violence comparable to those in times of civil war. What changes are the labels under which violence is recorded and discussed. Political, conflict-related violence between armed groups, the government and civilians becomes ‘ordinary crime’ after conflict is officially resolved. This article argues that the divide between ‘violence’ and ‘crime’ is of conceptual rather than empirical nature. It employs a strictly empirical analysis of forms of violence in KwaZulu-Natal (South Africa) to show how certain manifestations of violence persist long after armed conflict is over. The study concludes that, instead of being treated as an inevitable consequence of apartheid history and enduring socioeconomic ills, violence needs to be an immediate focus of post-conflict development agendas.
The Cypriot Civil Society movement: A legitimate player in the peace process?
Authors: Jarraud Nicolas , Louise Christopher , Filippou Giorgos
Published: July 2013

Efforts to resolve Cyprus's frozen conflict have frustrated the international community for nearly forty years. One of the causes of this lack of progress is a fundamental ‘democratic deficit’ in previous efforts at peacebuilding. In response to this deficit, a civil society movement for peace has slowly but inexorably emerged in the last few decades, engaging in a wide range of reconciliation efforts. In light of an ever-evolving enabling environment, this paper asks if this civil society movement has acquired the capacity and the constituency that could establish it as a legitimate interlocutor within an expanded peace process.
Calpain A modulates Toll responses by limited Cactus/IκB proteolysis
Authors: Fontenele Marcio , Lim Bomyi , Oliveira Danielle , Buffolo Márcio , Perlman David H. , Schupbach Trudi , Araujo Helena
Published: July 2013

Calcium-dependent cysteine proteases of the calpain family are modulatory proteases that cleave their substrates in a limited manner. Among their substrates, calpains target vertebrate and invertebrate IκB proteins. Because proteolysis by calpains potentially generates novel protein functions, it is important to understand how this affects NFκB activity. We investigate the action of Calpain A (CalpA) on the Drosophila melanogaster IκB homologue Cactus in vivo. CalpA alters the absolute amounts of Cactus protein. Our data indicate, however, that CalpA uses additional mechanisms to regulate NFκB function. We provide evidence that CalpA interacts physically with Cactus, recognizing a Cactus pool that is not bound to Dorsal, a fly NFκB/Rel homologue. We show that proteolytic cleavage by CalpA generates Cactus fragments lacking an N-terminal region required for Toll responsiveness. These fragments are generated in vivo and display properties distinct from those of full-length Cactus. We propose that CalpA targets free Cactus, which is incorporated into and modulates Toll-responsive complexes in the embryo and immune system.
Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits
Authors: Bhandari Deepali , Zhang Jinzhong , Menon Shekar , Lord Christopher , Chen Shuliang , Helm Jared R. , Thorsen Kevin , Corbett Kevin D. , Hay Jesse C. , Ferro-Novick Susan
Published: July 2013

Traffic from the endoplasmic reticulum (ER) to the Golgi complex is initiated when the activated form of the GTPase Sar1p recruits the Sec23p-Sec24p complex to ER membranes. The Sec23p-Sec24p complex, which forms the inner shell of the COPII coat, sorts cargo into ER-derived vesicles. The coat inner shell recruits the Sec13p-Sec31p complex, leading to coat polymerization and vesicle budding. Recent studies revealed that the Sec23p subunit sequentially interacts with three different binding partners to direct a COPII vesicle to the Golgi. One of these binding partners is the serine/threonine kinase Hrr25p. Hrr25p phosphorylates the COPII coat, driving the membrane-bound pool into the cytosol. The phosphorylated coat cannot rebind to the ER to initiate a new round of vesicle budding unless it is dephosphorylated. Here we screen all known protein phosphatases in yeast to identify one whose loss of function alters the cellular distribution of COPII coat subunits. This screen identifies the PP2A-like phosphatase Sit4p as a regulator of COPII coat dephosphorylation. Hyperphosphorylated coat subunits accumulate in the sit4Δ mutant in vivo. In vitro, Sit4p dephosphorylates COPII coat subunits. Consistent with a role in coat recycling, Sit4p and its mammalian orthologue, PP6, regulate traffic from the ER to the Golgi complex.
Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells
Authors: Inanç Burcu , Pütz Monika , Lalor Pierce , Dockery Peter , Kuriyama Ryoko , Gergely Fanni , Morrison Ciaran G.
Published: July 2013

Centrosomes are key microtubule-organizing centers that contain a pair of centrioles, conserved cylindrical, microtubule-based structures. Centrosome duplication occurs once per cell cycle and relies on templated centriole assembly. In many animal cells this process starts with the formation of a radially symmetrical cartwheel structure. The centrosomal protein Cep135 localizes to this cartwheel, but its role in vertebrates is not well understood. Here we examine the involvement of Cep135 in centriole function by disrupting the Cep135 gene in the DT40 chicken B-cell line. DT40 cells that lack Cep135 are viable and show no major defects in centrosome composition or function, although we note a small decrease in centriole numbers and a concomitant increase in the frequency of monopolar spindles. Furthermore, electron microscopy reveals an atypical structure in the lumen of Cep135-deficient centrioles. Centrosome amplification after hydroxyurea treatment increases significantly in Cep135-deficient cells, suggesting an inhibitory role for the protein in centrosome reduplication during S-phase delay. We propose that Cep135 is required for the structural integrity of centrioles in proliferating vertebrate cells, a role that also limits centrosome amplification in S-phase–arrested cells.
WD60/FAP163 is a dynein intermediate chain required for retrograde intraflagellar transport in cilia
Authors: Patel-King Ramila S. , Gilberti Renée M. , Hom Erik F. Y. , King Stephen M.
Published: July 2013

Retrograde intraflagellar transport (IFT) is required for assembly of cilia. We identify a Chlamydomonas flagellar protein (flagellar-associated protein 163 [FAP163]) as being closely related to the D1bIC(FAP133) intermediate chain (IC) of the dynein that powers this movement. Biochemical analysis revealed that FAP163 is present in the flagellar matrix and is actively trafficked by IFT. Furthermore, FAP163 copurified with D1bIC(FAP133) and the LC8 dynein light chain, indicating that it is an integral component of the retrograde IFT dynein. To assess the functional role of FAP163, we generated an RNA interference knockdown of the orthologous protein (WD60) in planaria. The Smed-wd60(RNAi) animals had a severe ciliary assembly defect that dramatically compromised whole-organism motility. Most cilia were present as short stubs that had accumulated large quantities of IFT particle–like material between the doublet microtubules and the membrane. The few remaining approximately full-length cilia had a chaotic beat with a frequency reduced from 24 to ∼10 Hz. Thus WD60/FAP163 is a dynein IC that is absolutely required for retrograde IFT and ciliary assembly.
Is the Association of Diabetes With Uncontrolled Blood Pressure Stronger in Mexican Americans and Blacks Than in Whites Among Diagnosed Hypertensive Patients?
Authors: Liu Xuefeng , Song Ping
Published: July 2013

BACKGROUND

Clinical evidence shows that diabetes may provoke uncontrolled blood pressure (BP) in hypertensive patients. However, racial differences in the associations of diabetes with uncontrolled BP outcomes among diagnosed hypertensive patients have not been evaluated.

METHODS

A total of 6,134 diagnosed hypertensive subjects aged ≥20 years were collected from the National Health and Nutrition Examination Survey 1999–2008 with a stratified multistage design. Odds ratios (ORs) and relative ORs of uncontrolled BP and effect differences in continuous BP for diabetes over race/ethnicity were derived using weighted logistic regression and linear regression models.

RESULTS

Compared with participants who did not have diabetes, non-Hispanic black participants with diabetes had a 138% higher chance of having uncontrolled BP, Mexican participants with diabetes had a 60% higher chance of having uncontrolled BP, and non-Hispanic white participants with diabetes had a 161% higher chances of having uncontrolled BP. The association of diabetes with uncontrolled BP was lower in Mexican Americans than in non-Hispanic blacks and whites (Mexican Americans vs. non-Hispanic blacks: relative OR = 0.55, 95% confidence interval (CI) = 0.37–0.82; Mexican Americans vs. non-Hispanic whites: relative OR = 0.53, 95% CI = 0.35–0.80) and the association of diabetes with isolated uncontrolled systolic BP was lower in Mexican Americans than in non-Hispanic whites (Mexican Americans vs. non-Hispanic whites: relative OR = 0.62, 95% CI = 0.40–0.96). Mexican Americans have a stronger associaton of diabetes with decreased systolic BP and diastolic BP than non-Hispanic whites, and a stronger association of diabetes with decreased diastolic BP than non-Hispanic blacks.

CONCLUSIONS

The association of diabetes with uncontrolled BP outcomes is lower despite higher prevalence of diabetes in Mexican Americans than in non-Hispanic whites. The stronger association of diabetes with BP outcomes in whites should be of clinical concern, considering they account for the majority of the hypertensive population in the United States.
Flammability of Surgical Drapes and Materials in Varying Concentrations of Oxygen
Authors: Culp William C. , Kimbrough Bradly A. , Luna Sarah
Published: July 2013

Background:

Over 600 operating room fires occur annually although many cases go unreported. Over 81% of operating room fires involve surgical drapes, yet limited data exist on the differing degrees of flammability of drapes and other surgical fuel sources in varying oxygen concentrations. The purpose of this study is to assess the flammability characteristics of fuels in the operating room under varying oxygen concentrations.

Methods:

Five fuel sources were analyzed in three levels of oxygen: 21%, 50%, and 100%. Three test samples of each material were burned in a manner similar to that established by the Consumer Product Safety Commission. Time to sample ignition and time to complete burn were measured with video analysis.

Results:

The median [minimum, maximum] ignition time in 21% oxygen was 0.9 s [0.3, 1.9], in 50% oxygen 0.4 s [0.1, 1.2], and in 100% oxygen 0.2 s [0.0, 0.4]. The median burn time in 21% oxygen was 20.4 s [7.8, 33.5], in 50% oxygen 3.1 s [1.4, 8.1], and in 100% oxygen 1.7 s [0.6, 2.7]. Time to ignite and total burn times decreased as oxygen concentration increased (P < 0.001). Flammability characteristics differed by material and oxygen concentration. Utility drapes and surgical gowns did not support combustion in room air, whereas other materials quickly ignited. Flash fires were detected on woven cotton materials in oxygen-enriched environments.

Conclusions:

Operating room personnel should be aware that common materials in the operating room support rapid combustion in oxygen-enriched environments. The risk of ignition and speed of fire propagation increase as oxygen exposure increases. Advances in material science may reduce perioperative fire risk.
Sensitivity analysis of infectious disease models: methods, advances and their application
Authors: Wu Jianyong , Dhingra Radhika , Gambhir Manoj , Remais Justin V.
Published: July 2013

Sensitivity analysis (SA) can aid in identifying influential model parameters and optimizing model structure, yet infectious disease modelling has yet to adopt advanced SA techniques that are capable of providing considerable insights over traditional methods. We investigate five global SA methods—scatter plots, the Morris and Sobol’ methods, Latin hypercube sampling-partial rank correlation coefficient and the sensitivity heat map method—and detail their relative merits and pitfalls when applied to a microparasite (cholera) and macroparasite (schistosomaisis) transmission model. The methods investigated yielded similar results with respect to identifying influential parameters, but offered specific insights that vary by method. The classical methods differed in their ability to provide information on the quantitative relationship between parameters and model output, particularly over time. The heat map approach provides information about the group sensitivity of all model state variables, and the parameter sensitivity spectrum obtained using this method reveals the sensitivity of all state variables to each parameter over the course of the simulation period, especially valuable for expressing the dynamic sensitivity of a microparasite epidemic model to its parameters. A summary comparison is presented to aid infectious disease modellers in selecting appropriate methods, with the goal of improving model performance and design.
Functions of the hydrophilic channels in protonmotive cytochrome
c
oxidase
Authors: Rich Peter R. , Maréchal Amandine
Published: July 2013

The structures and functions of hydrophilic channels in electron-transferring membrane proteins are discussed. A distinction is made between proton channels that can conduct protons and dielectric channels that are non-conducting but can dielectrically polarize in response to the introduction of charge changes in buried functional centres. Functions of the K, D and H channels found in A1-type cytochrome
c
oxidases are reviewed in relation to these ideas. Possible control of function by dielectric channels and their evolutionary relation to proton channels is explored.
Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine
Authors: Vielreicher M. , Schürmann S. , Detsch R. , Schmidt M. A. , Buttgereit A. , Boccaccini A. , Friedrich O.
Published: July 2013

This review focuses on modern nonlinear optical microscopy (NLOM) methods that are increasingly being used in the field of tissue engineering (TE) to image tissue non-invasively and without labelling in depths unreached by conventional microscopy techniques. With NLOM techniques, biomaterial matrices, cultured cells and their produced extracellular matrix may be visualized with high resolution. After introducing classical imaging methodologies such as µCT, MRI, optical coherence tomography, electron microscopy and conventional microscopy two-photon fluorescence (2-PF) and second harmonic generation (SHG) imaging are described in detail (principle, power, limitations) together with their most widely used TE applications. Besides our own cell encapsulation, cell printing and collagen scaffolding systems and their NLOM imaging the most current research articles will be reviewed. These cover imaging of autofluorescence and fluorescence-labelled tissue and biomaterial structures, SHG-based quantitative morphometry of collagen I and other proteins, imaging of vascularization and online monitoring techniques in TE. Finally, some insight is given into state-of-the-art three-photon-based imaging methods (e.g. coherent anti-Stokes Raman scattering, third harmonic generation). This review provides an overview of the powerful and constantly evolving field of multiphoton microscopy, which is a powerful and indispensable tool for the development of artificial tissues in regenerative medicine and which is likely to gain importance also as a means for general diagnostic medical imaging.
Microtubule dynamics in neuronal morphogenesis
Authors: Sakakibara Akira , Ando Ryota , Sapir Tamar , Tanaka Teruyuki
Published: July 2013

Microtubules (MTs) are essential for neuronal morphogenesis in the developing brain. The MT cytoskeleton provides physical support to shape the fine structure of neuronal processes. MT-based motors play important roles in nucleokinesis, process formation and retraction. Regulation of MT stability downstream of extracellular cues is proposed to be critical for axonogenesis. Axons and dendrites exhibit different patterns of MT organization, underlying the divergent functions of these processes. Centrosomal positioning has drawn the attention of researchers because it is a major clue to understanding neuronal MT organization. In this review, we focus on how recent advances in live imaging have revealed the dynamics of MT organization and centrosome positioning during neural development.
The PYL4 A194T Mutant Uncovers a Key Role of PYR1-LIKE4/PROTEIN PHOSPHATASE 2CA Interaction for Abscisic Acid Signaling and Plant Drought Resistance
Authors: Pizzio Gaston A. , Rodriguez Lesia , Antoni Regina , Gonzalez-Guzman Miguel , Yunta Cristina , Merilo Ebe , Kollist Hannes , Albert Armando , Rodriguez Pedro L.
Published: July 2013

Because abscisic acid (ABA) is recognized as the critical hormonal regulator of plant stress physiology, elucidating its signaling pathway has raised promise for application in agriculture, for instance through genetic engineering of ABA receptors. PYRABACTIN RESISTANCE1/PYR1-LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS ABA receptors interact with high affinity and inhibit clade A phosphatases type-2C (PP2Cs) in an ABA-dependent manner. We generated an allele library composed of 10,000 mutant clones of Arabidopsis (Arabidopsis thaliana) PYL4 and selected mutations that promoted ABA-independent interaction with PP2CA/ABA-HYPERSENSITIVE3. In vitro protein-protein interaction assays and size exclusion chromatography confirmed that PYL4A194T was able to form stable complexes with PP2CA in the absence of ABA, in contrast to PYL4. This interaction did not lead to significant inhibition of PP2CA in the absence of ABA; however, it improved ABA-dependent inhibition of PP2CA. As a result, 35S:PYL4A194T plants showed enhanced sensitivity to ABA-mediated inhibition of germination and seedling establishment compared with 35S:PYL4 plants. Additionally, at basal endogenous ABA levels, whole-rosette gas exchange measurements revealed reduced stomatal conductance and enhanced water use efficiency compared with nontransformed or 35S:PYL4 plants and partial up-regulation of two ABA-responsive genes. Finally, 35S:PYL4A194T plants showed enhanced drought and dehydration resistance compared with nontransformed or 35S:PYL4 plants. Thus, we describe a novel approach to enhance plant drought resistance through allele library generation and engineering of a PYL4 mutation that enhances interaction with PP2CA.
Analysing the impacts of ICT on knowledge work productivity
Authors: Palvalin Miikka , Lönnqvist Antti , Vuolle Maiju
Published: July 2013

Purpose

The potential of information and communication technology (ICT) in improving knowledge work productivity is well‐documented in the existing literature. However, prior research fails to provide means for analyzing whether the potential can be realized in a specific organizational context. Thus, this paper aims to focus on the context‐specific analysis of the impacts of ICT services on knowledge work.

Design/methodology/approach

This paper uses a literature review and a case study conducted in a medium‐sized European teleoperator company. The case study examines the measurement process for capturing the knowledge work productivity impacts produced by a new ICT service used by the company.

Findings

ICT can be used to eliminate non‐value‐adding tasks or to make them more efficient. ICT can also improve employee welfare, for example, through transforming the content of work by deleting unimportant activities. The empirical study showed that, contrary to the view presented in the prior literature, it does not seem that difficult to measure the impacts of ICT on knowledge work productivity. A key point in the measurement is identification of case‐specific impact factors by examining the characteristics of the ICT service and the organisational setting.

Practical implications

The results of the paper will be useful for managers studying the impacts of ICT investments in their organizations.

Originality/value

This paper contributes to the prior literature on ICT and knowledge work productivity by explaining how the impacts of ICT can be analysed in a given empirical context. The specific novelty value of the study lies in the new knowledge concerning the identification of the impact factors.
Common topics in eighteenth‐century prefaces to English school grammars: an application of theECEGdatabase
Authors: Rodríguez‐Álvarez Alicia , Rodríguez‐Gil María E.
Published: July 2013

This paper aims to shed light on an issue which has remained unexplored hitherto: common topics in the prefaces to eighteenth‐century English school grammars. The study is based on a corpus of nineteen grammars, retrieved from the Eighteenth‐Century English Grammars database (ECEG), which fulfilled the following criteria: grammars (i) published as stand‐alone books, (ii) written by authors born in the British Isles, and (iii) intended for school use mainly. Our analysis contributes to broaden our understanding of the normative grammatical tradition by showing how these prefaces contain a highly homogeneous set of ideas, beliefs and objectives, while, at the same time, they show varied trends in their approaches.
John Newbery's An easy introduction to the English language (1745): audience, origin and the question of authorship
Authors: Navest Karlijn , Sairio Anni
Published: July 2013

An Easy Introduction to the English Language (1745) is the grammar in the Circle of the Sciences series, a children's encyclopaedia published by John Newbery. The volumes in the Circle series were established reading material for boys and girls in Georgian England, and the grammar targeted a broad audience of children, young men and women and non‐native speakers. A comparison between James Greenwood's (1711) and (1737) popular works shows that the Circle grammar was largely plagiarised from Greenwood's grammars. The grammar is generally attributed to Newbery, but an advertisement in the London Gazette links the Circle series to author and playwright Eliza Haywood.
Quality Properties, Fatty Acids, and Biogenic Amines Profile of Fresh Tilapia Stored in Ice
Authors: Kulawik Piotr , Özoğul Fatih , Glew Robert H.
Published: July 2013

This work determines quality properties and fatty acids content of Nile tilapia (Oreochromis niloticus) stored in ice for 21 d. The quality properties consist of thiobarbituic acid (TBA), total volatile basic nitrogen (TVB‐N), trimethylamine (TMA), and microbiological analysis (total viable count (TVC), total coliform, Salmonella and Staphylococcus aureus) and determination of biogenic amines content (histamine, cadaverine, putrescine, spermine, spermidine, 2‐phenylethylamine, agmatine, tyramine, and ammonia). Moreover, the fat, moisture, and ash composition as well as fatty acids profile have also been analyzed. The TBA, TVB‐N, and biogenic amines analysis showed rather low levels of spoilage even after 21 d of storage. The microbiological analysis, however, showed that tilapia was unsuitable for consumption after just 10 d. The fat, ash, moisture, and fatty acids profile analysis showed that tilapia is not a good source of n−3 fatty acids. The research indicated that the microbiological analysis was the best method to establish spoilage of tilapia stored in ice, of all analytical methods performed in this study.
Inhibition of Bacterial and Filamentous Fungal Growth in High Moisture, Nonsterile Corn with Intermittent Pumping of Trans‐2‐Hexenal Vapor
Authors: De Lucca Anthony J. , Carter‐Wientjes Carol H. , Boué Stephen M. , Lovisa Mary P. , Bhatnagar Deepak
Published: July 2013

Trans‐2‐hexenal (T2H), a plant‐produced aldehyde, was intermittently pumped over a 7 d period into a small, bench top model of stored corn (nonsterile, moisture content about 23%). Naturally occurring bacteria and fungi, including added Aspergillus flavus, grew rapidly on corn not treated with T2H vapor. However, intermittently pumped T2H (30 min per 2 h or 30 min per 12 h) significantly reduced bacterial and fungal viable populations, with nearly 100% fungal viability loss observed after either (1) one day of pumping at the 30 min per 2 h rate or (2) pumping cycles of 30 min per 12 h period over the initial 48 to 72 h of incubation. Data suggest that short‐term intermittent fumigation of stored corn with T2H could prevent growth of bacteria and mycotoxigenic fungi such as A. flavus.
Practical Real‐Time Lens‐Flare Rendering
Authors: Lee Sungkil , Eisemann Elmar
Published: July 2013

We present a practical real‐time approach for rendering lens‐flare effects. While previous work employed costly ray tracing or complex polynomial expressions, we present a coarser, but also significantly faster solution. Our method is based on a first‐order approximation of the ray transfer in an optical system, which allows us to derive a matrix that maps lens flare‐producing light rays directly to the sensor. The resulting approach is easy to implement and produces physically‐plausible images at high framerates on standard off‐the‐shelf graphics hardware.