bluuebunny/crossref_metadata_2025 huggingface dataset:
Providencia rettgeri and Sporosarcina koreensis as efficient cell factories for valorization of palm oil mill effluent to produce polyhydroxyalkanoates
Authors: Ezechukwu Precious Somtochukwu , Ugwuanyi Jerry Obeta
Published: December 2024

Polyhydroxyalkanoates (PHAs) are versatile carbon-neutral, eco-friendly biopolymers that can replace highly polluting petroleum plastics. Microorganisms accumulate PHAs in response to stress. Unfortunately, PHA is more expensive than plastics due to high cost of feedstock. Palm Oil Mill Effluent (POME) an abundant waste from oil palm production can support sustainable production of PHA using appropriate microorganism. Fresh and naturally acidified POME were used as negative-cost feedstock to produce PHA using novel bacteria. Six of 247 isolates obtained from POME / dumpsite soil efficiently accumulated between 19 and 72% PHA. Two isolates that accumulated the most polymers were identified as Providencia rettgeri and Sporosarcina koreensis. At optimum yield they accumulated respectively 4.2g/L (72% of 5.8g/L biomass) and 3.4g/L (66% of 5.15g/L biomass) in POME at 72hours. Optimization studies show that pH 6, C:N ratio, 25:1, titratable acidity, 0.39% for both isolates, and inoculum size, 10% v/v for Providencia rettgeri and 5% v/v for Sporosarcina koreensis gave maximum concentration of PHA at 72hours. Fourier transform infrared spectroscopy (FT-IR) and GC-MS analysis of the polymer accumulated by both isolates identified the products as a poly-hydroxyl-butyrate (PHB). This work is reporting for the first time the use of P. rettgeri and S. koreensis in sustainable processes to valorize major agricultural pollutant to value-added high-cost biochemical. The yield of PHA by these isolates on POME feedstock is promising enough to serve as basis for sustainable industrial process. The waste effluent is reduced for COD and pollution potential and may safely be discharged to environment.
On Language attitudes and Language endangerment: The Dompo Language of Ghana in perspective
Authors: Manu-Barfo Esther Desiadenyo
Published: December 2024

The Dompo language, spoken in the North-Western part of the Bono Region of Ghana is a highly endangered language. The language has a remaining aged fluent speaker base of about three people, and a few other natives who have some basic knowledge ofits vocabulary. Dompo has lost its vibrancy to the Nafaanra language, whose speakers are believed to have migrated from the neighbouring country of Ivory Coast. Nafaanra is currently not only the language of everyday usage in the Dompo community, but is also the first language of most of the native Dompo people. This paper discusses the results of a survey of 100 local respondents in the Dompo community about their attitudes towards Dompo and their views on the causes of the degeneration of the language. 66respondents identified as native Dompos while 34 stated that they were Nafaanras. All the native Dompos recounted that while they have a positive attitude towards their language despite its current state, they bemoan its non-transmittal to them by their olderkinsmen. Intermarriages between Dompos and Nafaanras, which further led to the subjugation of the language, emigration of fluent speakers to other communities, lack of interest on the part of the younger generation to learn Dompo, and the language being used as a secret language to tattle about others,c are among some of the reasons given for the decline of the language.
Who Owns Africa? Neocolonialism, Investment, and the New Scramble
Authors: Bosomprah Ebenezer
Published: December 2024

Review of Bekeh Utietiang Ukelina (ed.) Who Owns Africa? Neocolonialism, Investment, and the New Scramble for Africa
The Nexus between Clean Energy and Human Rights: Evaluating the Legal Framework for Advancing Sustainable Development Goals in Nigeria
Authors: Ogbodo-Nathaniel Peace Amayo , Olujobi Olusola Joshua , Izu Cynthia Chukwufumnanya , Ogbodo Nathaniel Imomion
Published: December 2024

All over the world, the issue of Climate change has become a growing concern as it disproportionately harms people's health, livelihoods, and security. By reducing reliance on fossil fuels, clean energy helps in protecting fundamental human rights. The United Nations recognises access to clean energy as essential for human health, development, and poverty eradication. Clean energy can improve air quality, provide reliable electricity for homes and businesses, and empower communities. Achieving sustainable development and upholding human rights requires the transition to clean and renewable energy sources. However, the implications of energy development on human rights are often overlooked by the legal framework that governs the energy sector in Nigeria. This article adopts a doctrinal legal research methodology and it examines the relationship between clean energy and human rights by evaluating the existing legal framework on human rights and its potentials to promote sustainable development goals through just transition to a low-carbon economy. The findings reveals the inadequacies and inconsistencies in the existing legal framework and offers recommendations for integrating clean energy development in Nigeria in conformity with human rights principles. This article recommends the adoption of human rights-based approach to energy development to promote access to clean energy, and promoting sustainable patterns of production and consumption through the legal framework, Nigeria can prioritise human rights, accomplish sustainable development goals, and ensure a fair and just transition to a low-carbon economy.
Relationship between body morphometry in Bapedi rams and sperm characteristics measured using Computer-aided Sperm Analysis
Authors: Maqhashu A. , O’Neill H.A. , Ngcobo J.N. , Nephawe K.A. , Ramukhithi F.V. , Sebei J.P. , Mapholi N.O. , Bovula N. , Mphaphathi M.L. , Nedambale T.L.
Published: December 2024

Ram fertility is not defined by a single trait. Quantifiable physical parameters that are correlated to fertilization capacity of sperm are required to advise farmers on ram selection activities. The objective was to investigate the relationship between body measurements and sperm traits of Bapedi rams conserved in situ and ex situ. Before semen collection and body measurements, body temperature was taken. Semen was collected from 33 rams (two ejaculates/ram weekly, with 2 d resting period, age = 2–6 y). Body weight (BW, kg), body measurements [body length, head length, head width, rump height, rump width, rump length, tail length, heart girth, and scrotal circumference (SC)]; and semen volume (ml), sperm concentration (billion/ml), and sperm motility parameters were measured using Computeraided Semen Analysis System (CASA®). The semen pH was measured using a microprocessor pH/mV/°C meter fitted with a glass probe. Body condition scores (BCS) of the rams were recorded on a scale of 1 to 5. Data were analysed using the PROC univariate procedure of SAS. BW of Bapedi rams was 38–57 kg in all groups. There was uniformity in all body measurements of Bapedi sheep regardless of method of conservation. Body temperature during semen collection; scrotal circumference; semen volume, pH, and concentration; sperm total motility; and kinematics in Bapedi rams using both methods of conservation were similar. Strong correlations between BW, BCS, and SC with semen volume were found. Rump length positively influenced sperm normality. BW, BCS, and SC can be included in the selection criteria for improving the reproductive performance of Bapedi breeding rams. Farmers can use SC and rump length to predict semen volume and sperm normality.
The effect of Ulva lactuca on in vitro ruminal gas production kinetics
Authors: Nell S. , Van Zyl J.H.C. , Goosen N.J. , Cruywagen C.W.
Published: December 2024

The aim of this study was to determine whether the inclusion of a marine algae found in South African waters, Ulva lactuca, can reduce total gas and methane production in vitro when it replaces lucerne hay in a mixed sheep feed at incremental levels. Four treatments were prepared and incubated using bovine rumen fluid as inoculum: (1) 0 g U. lactuca kg-1 feed dry matter (DM) (0U), (2) 25 g U. lactuca kg-1 feed DM (25U), (3) 50 g U. lactuca kg-1 feed DM (50U), and (4) 100 g U. lactuca kg-1 feed DM (100 U). Total gas and CO2 production was determined with the aid of an automated system and methane production was estimated by difference. Cumulative gas production data were fitted to a non-linear model (Y = b(1- exp-c(t-L))) to estimate values for total gas production (b, mL), rate of gas production (c, mL/h), and a discrete lag time (L, hours). The extent of total gas production was lower for 100U than for 25U, but neither differed from 0U or 50 U. The lag time observed was lower for 50U than 0U, but neither differed from 25U or 100U. No differences were found for the rate of gas production. No differences for any gas production values were observed between treatments. The ratio between methane and total gas production was highest for 100U, which differed from 25U, but not from 0U or 50U. The higher methane ratio observed in the 100U treatment may be attributed to the lower total gas production in this treatment due to the lower fermentability of U. lactuca compared to lucerne.
Assessment of total and free testosterone, prolactin level among infertile women attending Gynecology Clinic in Ondo State.
Authors: Salimon Yahaya Adesina , Olaniyan Mathew Folarinmi
Published: December 2024

Infertility is a significant concern affecting many women, and hormonal imbalances can often contribute to this issue. The aim of this study was to assess the levels of total and free testosterone as well as prolactin levels in infertile women attending a Gynecology Clinic in Ondo State. The study involved a sample of infertile women who were assessed for total and free testosterone, as well as prolactin levels through blood tests. The data collected was analyzed to determine the prevalence of abnormal hormone levels in this population. Understanding the hormonal status of infertile women can provide valuable insights into potential underlying causes of infertility, thereby guiding appropriate treatment strategies. There was significantly lower free testosterone in primary infertile women when compared with control (p<0.05). The free testosterone was significantly lower in secondary infertile women when compared with control p<0.05 but not significant when compared primary and secondary infertile women (p>0.05). The total testosterone was significantly lower in secondary infertile women (p<0.05) when compared with control and higher in primary infertile women when compared with control (p<0.05) but no significant when compared primary with secondary infertile women. The findings from this study may contribute to the development of more targeted and effective interventions for infertility in women. This research is crucial for healthcare providers and policymakers in Ondo State to improve the management and care of infertile women attending gynecology clinics.
Evaluation of the combined extract of Rauwolfia vomitoria and Aframomum melegueta on the kidney and liver of adult male Wistar rats
Authors: Adeniyi Temidayo Daniel , Akinpelu Moronkeji , Akinlami Omokehinde Oseni , Alaga Firdaws Oriade , Adenika Mofesola Mojisola
Published: December 2024

Phytomedicine, also known as herbal medicine, has seen a great upsurge globally. It refers to the use of plants, herbs, and mixtures of well-known plant metabolites to cure and mitigate human diseases. They are often used because they are natural and therefore assumed to be safer than allopathic medicines. In recent times, however, there has been a growing concern about their safety. This study aimed to evaluate the combined effect of methanolic extract of Rauwolfia vomitoria and Aframomum melegueta on renal and liver morphology of experimental animals with respect to the expression of Interleukin 10 (IL-10) and nuclear factor erythroid 2-related factor 2 (NRF2). Twenty adults male Wistar rats weighing 180-230 g were grouped into four consisting of a control and three test groups. While the control rats were administered with distilled water only, the rats in groups II and III were singly administered with methanolic extracts of Rauwolfia vomitoria and Aframomum melegueta at standard doses of 250 mg/kg/BW respectively while rats in group IV were co-administered with the methanolic extracts of Rauwolfia vomitoria and Aframomum melegueta at 250 mg/kg/BW respectively. At the end of the experiment, the rats were euthanized, and the kidneys and livers were analyzed for histological and mRNA analysis. Histopathological findings revealed no cytopathic lesions on the renal and liver morphology across all groups while mRNA expression studies indicated the anti-inflammatory and antioxidant effects of the plants by upregulating the expression of IL-10 and Nrf-2 in the treated groups. The administration of the leaf extracts of Rauwolfia vomitoria and Aframomum melegueta at a dosage of 250 mg/kg/BW has no cytopathic effects on the kidney and liver morphology of Wistar rats with the co-administrative extract treatment better upregulating the expression of IL-10 and NRF-2 than single administration in the treated rats thus indicating its antioxidative potential and safety of usage and further validating their use in traditional medical practice.
Aqueous rhizome extract of Zingiber officinale: Assessing its efficacy against arsenic-induced liver damage in Wistar rats.
Authors: Imafidon E. , Abba H.N.
Published: December 2024

The liver is especially vulnerable to toxins due to its role in metabolizing and clearing chemicals. Heavy metals like arsenic, found in contaminated water, food, and industrial processes, are well-documented hepatotoxic agents. Traditionally, medicinal plants like Zingiber officinale have been used to treat liver ailments. Known for its gastroprotective and hepatoprotective effects, Zingiber officinale, with its safety profile and ability to mitigate oxidative stress, is a promising candidate for preventing and treating hepatotoxicity. The aim of this study was to assess the effect of Zingiber officinale against arsenic trioxide-induced hepatotoxicity in Wistar rats. Thirty adult Wistar rats were randomly assigned into six groups (A–F). Group A served as control; Group B - 10 mg/kg As2O3 only; Group C - 190 mg/kg body weight of Zingiber officinale stem extract and 10 mg/kg As2O3; Group D - 380 mg/kg body weight of Zingiber officinale stem extract and 10 mg/kg As2O3; Group E - 50 mg/kg body weight of standard drug (silymarin) and 10 mg/kg As2O3; Group F - 380 mg/kg body weight of Zingiber officinale stem extract. The administration lasted 28 days. Afterwards, the animals were anesthetized and sacrificed, and samples were taken for oxidative stress-related parameters, liver function assessments, and histological evaluation. Findings showed significant changes (p<0.05) in the arsenic trioxide-only group, including decreased SOD and GSH levels, increased MDA levels, and elevated levels of ALT, AST, and total bilirubin, indicating liver damage. Histological analysis showed severe liver damage evidenced by vasodilation and congestion, zonal necrosis, and periportal infiltrates of inflammatory cells. However, pre-treatment with Zingiber officinale protected against these effects, leading to increased (p<0.05) SOD and GSH levels, decreased (p<0.05) MDA levels, and improved histological architecture with relatively normal liver histology. In conclusion, these findings suggest that Zingiber officinale possesses a protective effect against arsenic trioxide-induced hepatotoxicity, possibly through its antioxidant, anti-inflammatory, and hepatoprotective properties.
Retracted Article
Authors: Hudu Shuaibu Abdullahi , Saeed Mohammed Ibrahim
Published: December 2024

Retracted article.
Modern contraceptives use among women in Terekeka County, Central Equatoria State, South Sudan
Authors: David Imba Alex , Otte Ambayo Peter , Ratib Mawa , Loponi Lou Eluzai
Published: December 2024

Introduction: The South Sudan health sector strategic plan indicates that only 1.2% of women aged 15-49 years have their need for family planning met, and the contraceptive prevalence rate of 6% is lower than the rate of 17% in the whole of sub-Saharan Africa. The use of modern contraceptives contributes to women’s health and reduces maternal mortality related to pregnancy and childbirth complications globally. The study investigated the utilization of modern contraceptives among women of reproductive age (WRA) in Terekeka County of South Sudan. 
Method: We employed cross-sectional, qualitative, and quantitative research involving in-depth interviews with key informants. Respondents were selected purposively and through a multistage random sampling technique. Data were analysed using thematic content analysis. 
Results: There were 384 respondents. The results indicate that 21.4% of the women use modern contraceptives. Demographic factors such as education, religion, marital status, knowledge, access to contraceptive information, and partner support are positively associated with the use of modern contraceptives in Terekeka County. 
Conclusion: We conclude that if all WRA had access to education and family planning information, many would use modern contraceptives. The study recommends more studies to explore the use of modern contraceptives in the whole country.
A review of one year malaria blood film data from a hospital in Yei, South Sudan
Authors: Obonyoh Kennedy , James Agnes , McIntosh J. Clarke
Published: December 2024

Although Rapid Diagnostic Tests (RDTs) are utilized more frequently today, blood films are still the gold standard for diagnosing malaria. This is an observational study, looking at the experience of His House of Hope and Faith Hospital (HHHF) in Yei, South Sudan, in one calendar year (January to December in 2023) tracking Plasmodium falciparum (PF) and other plasmodium species. We report some simultaneous data using RDT for malaria and data regarding co-infection with Salmonella typhi (Typhoid fever).
Molecular docking simulation of Bioactive Compounds from Curcuma longa against Helicobacter pylori
Authors: Mbise Alex J. , Kanaka Rao Pulapa V. , Stanley F.M.
Published: December 2024

Peptic ulcers are open sores that form on the lining of the stomach and upper small intestine and the primary causative pathogen is Helicobacter pylori. In this research, the inhibitory activities of bioactive compounds from Curcuma longa, against H. pylori (8H52) were studied. Eighty-three significant bioactive compounds were selected from the Zinc database and were initially screened using absorption, distribution, metabolism, excretion, and toxicity properties based on compliance with the Pfizer rule. Molecular docking studies were carried out with specific docking site dimensions of values x: -37.3658, y: -4.1028, and z: -22.8563, to identify the binding affinities and interactions. Ten phytoconstituents scored binding affinities between -7.8 and -10.1 kcal/mol. When compared to the control drug omeprazole (-8.8 kcal/mol), the compounds curcumin pyrazole (-10 kcal/mol), 4'-O-methylcatechin (-9.5 kcal/mol), and curcumin (-9.3 kcal/mol) displayed significant binding affinities and good interactions with alanine, valine, aspartic acid and glutamic acid amino acids respectively forming H-bonds with the phytochemicals. These results indicate that curcumin pyrazole, 4'-O-methylcatechin, and curcumin from C. longa can be used as potential inhibitors for H. pylori against peptic ulcers with no adverse effects.
Keywords:    Helicobacter pylori; Peptic ulcers; Bioactive compounds; Molecular docking; Curcumin pyrazole
Biomedical Potential of Natural Products from Selected Tanzanian Flora: A Review
Authors: Nyandoro Stephen S. , Munissi Joan J.E.
Published: December 2024

Natural products have been used for treatment of various diseases for thousands of years and served as sources of drug lead compounds for the improvement of livelihood. This paper presents a review on the biomedical potentials of selected natural products isolated from eight plant species indigenous to Tanzania. The review covers research work published between 2010 and 2023, and identifies 33 natural products with different pharmacological properties from Tanzanian plants. These bioactive natural products are discussed with other similar compounds isolated elsewhere from the same or different plant species to get further insights on the potential application in modern medicine based on information obtained from online search from different databases including Chemical Abstract, Google Scholar, MEDLINE, PubMed and Science Direct using different key words or phrases. The review includes antitubercular, anticancer and neuroprotective flavonoids from Erythrina schliebenii (Fabaceae), antitubercular and antioxidant metabolites from three mangrove species Heritiera littoralis (Sterculiaceae), Xylocarpus granatum (Meliaceae) and Sonneratia alba (Lythraceae). The review also covers antiplasmodial secoiridoids and iridoids from Morinda asteroscepa (Rubiaceae), antibacterial biflavonoids from two Ochna species (Ochnaceae), antiviral and antiplasmodial diterpenoids from Croton kilwae (Euphorbiaceae), and other constituents from these plant species. Most of these plants are rare, endemic or near endemic in Tanzania. Of these natural products, the catechinoid 13 (IC50 4.5 µg/mL) was four times more active than the positive control towards radical scavenging, the biflavonoid 31 (MIC 2.2 μM) was more potent in antibacterial assay than the standard drug, whereas diterpenoids 34-36 demonstrated strong anti-proliferative effect against the malaria parasite Plasmodium falciparum (80-100%, at 50 μM), making them promising candidates for drug development. The review argues about challenges associated with the realization of the full potential of biomedical agents such as scalability, toxicity, solubility, and bioavailability thereby calling for concerted research endeavors to address them to exploit effusively the potential that resides in the natural products towards drug development. The mode of actions of the lead compounds must be elucidated and clinical studies conducted for targeted disease treatments.
Tanzanian flora; antiplasmodial; anticancer; antioxidant; antiviral; antibacterial; neuroprotective; anti-inflammatory
Fixed Point Theorems and Sensitivity Analysis in Solving Nonlinear Matrix Equations: A Study Involving Partially Ordered Sets
Authors: Chacha Chacha Stephen
Published: December 2024

Nonlinear matrix equations of the form   , where  represents an unknown matrix, and     and  are given square matrices, are encountered in various fields. Understanding the characteristics and behaviour of these equations is essential for developing efficient computational methods and obtaining reliable solutions. This paper explores the use of partially ordered sets within fixed point schemes to solve the targeted equations. Furthermore, it derives perturbation estimates of the solutions and evaluates them computationally. Finally, the numerical simulations are provided to validate our theoretical claims and affirm the effectiveness of the proposed fixed-point scheme.
Keywords:    Fixed point, partially ordered sets, Nonlinear matrix equation, Positive definite solution, Perturbation
A Mathematical Model for Malaria Transmission Dynamics in the Population with Different Immune Status
Authors: Mbugi Neema S. , Irunde Jacob I. , Mwasunda Joshua A. , Kiware Samson
Published: December 2024

Malaria is a febrile illness affecting a large population worldwide. Even though malaria is curable and preventable it continues to pose a significant health risk, economic effects, and social effects in the population. This study formulates a mathematical model to study the transmission dynamics of malaria in a population with different immune status. By dividing the population based on immune status, the model provides insights into how immunity influences the interaction between hosts and malaria parasites, particularly in terms of infection rates, immune responses, and propose appropriate control for effective elimination. The basic reproduction number is computed using the next-generation matrix approach. The analysis shows that the model can undergo forward bifurcation when the basic reproduction number , thus, the condition of  necessary and sufficient for malaria elimination. The numerical simulation results indicate that non-immune individuals play a more significant role in malaria transmission compared to semi-immune individuals. This is because non-immune individuals, lacking strong immunity, are more susceptible to malaria infection. Moreover, the results highlight the effect of mosquito biting rates on the susceptible and infectious population. The findings underscore the importance of considering immune heterogeneity within the population when developing strategies to control and eventually eradicate malaria.
Repenser l’échange amoureux avec Cixous et Wittig : Entre critique et réinventions
Authors: Batko Meyer Sofía
Published: December 2024

Starting from the correlation highlighted by feminist theory between love and the heterosexist structure of relationships, this essay looks at the attempts to reinvent love initiated by two French writers of the 1970s, Hélène Cixous and Monique Wittig. To this end, the paper approaches the question of love in the work of Cixous and Wittig in terms of exchange, which it breaks down into three aspects. The first aspect concerns the libidinal question, insofar as love involves a relationship with the other that implies desire as an overflow. The second aspect considers the love relationship from an ethical angle, questioning the status of the love partner as otherness and difference. The third and final aspect looks at the consequences for the political economy of relationships of a resignification of love exchange based on a new approach to the act of giving.
Yes means yes and no means no? A critical sociolinguistic analysis of cultural assumptions and transnationalism in Polish online sexual education discourses on sexual consent
Authors: O’Toole Olga
Published: December 2024

The subject of sexual consent has received increasing media and academic attention in recent years and the question of its sociolinguistic significance has been investigated in the context of the English language in Canadian, American, and British settings (sources). There seems to be a lack of cross-cultural analyses; however, little research has investigated the complexities of consent as far as attitudes and discourses. This paper presents an analysis of sexual education discourse taken from Polish grassroots sexual education initiatives and looks at the phenomenon of changes in discourse on consent, as well as signs of linguistic imperialism in sexual consent education practices. The project takes a qualitative approach to integrating critical discourse analysis (CDA) and feminist post-structural discourse analysis (FPDA), in which five sources of sexual consent materials found online are analyzed for the linguistic remnants of cultural assumptions about sexuality. This is done to investigate the implied understandings of roles in giving and asking for sexual consent, which at the same time work towards a more progressive discourse on sexuality.
Nghiên cứu hoạt tính sinh học của hoa đu đủ đực Carica papaya L. trên một số dòng tế bào ung thư phổ biến
Authors: Dung Ngô Thị Phương , Dũng Nguyễn Hoàng
Published: December 2024

Cây đu đủ đực Carica papaya L. được trồng phổ biến ở Việt Nam, hoa của nó có nhiều tác dụng dược lý. Nghiên cứu này đề cập đến các hoạt tính sinh học gồm hiệu quả kháng oxy hóa và chống ung thư của cao chiết phân đoạn hoa đu đủ đực. Hoa đu đủ đực được ly trích bằng dung môi methanol với hiệu suất tách chiết là 15.76%. Hiệu suất thu nhận cao chiết phân đoạn n-hexan, chloroform, ethyl acetate và nước lần lượt là: 11.48; 7.32; 8.05; 73.15%. Hàm lượng polyphenol cao nhất trong cao phân đoạn nước là 88.15 ± 1.37 µg GAE/mg cao chiết, tương ứng với hiệu quả kháng oxy hóa tốt nhất với EC50 là 431.10 µg/mL được đo bằng phương pháp 1,1-diphenyl-2-picrylhydrazyl (DPPH). Dùng phương pháp 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) để kiểm tra hiệu quả gây độc tế bào, các dịch chiết phân đoạn đã ức chế tế bào ung thư HepG2, K562 và B16F10. Dịch chiết nước không có hoạt tính gây độc, nằm ngoài phạm vi khảo sát (IC50 > 400 µg/mL). Dịch chiết n-hexan ức chế tốt HepG2 (IC50 = 196.79 µg/mL), còn dịch chiết chloroform và ethyl acetate ức chế tốt K562 (IC50 = 83.23 µg/mL và 89.33 µg/mL). Nghiên cứu này được xem như bước đầu trong quá trình sàng lọc và cô lập các hợp chất sinh học từ hoa đu đủ đực ở tỉnh Đắk Lắk, tập trung vào các hợp chất có khả năng gây độc tế bào ung thư.
Đánh giá khả năng tiết chitinase ngoại bào và đối kháng nấm Pyricularia oryzae của vi khuẩn và xạ khuẩn phân lập từ đất vùng rễ lúa ở tỉnh Kiên Giang
Authors: Hòa Đinh Anh , Phấn Trần Thị , Trang Trần Thùy , Nguyệt Nguyễn Thị Ánh , Dương Nguyễn Thị Thùy , An Nguyễn Hải , Châm Lê Thị Mai
Published: December 2024

Nấm Pyricularia oryzae là một trong những đối tượng gây bệnh đạo ôn ở cây lúa. Cơ chế lây nhiễm là xâm nhiễm trực tiếp qua màng sinh chất, tiết ra độc tố tế bào và hình thành tế bào truyền nhiễm chuyên gây bệnh cho cây lúa ở một số loài (Muni & Nadarajah, 2014). Vì vậy, chế phẩm chứa các hoạt chất sinh học từ vi sinh vật có khả năng kháng nấm gây bệnh và không gây hại cho con người với môi trường, là biện pháp đầy tiềm năng để quản lý nấm gây bệnh trên lúa. Thuộc nhóm vi sinh vật có lợi, vi khuẩn và xạ khuẩn vùng rễ được biết đến là nhóm ứng dụng khả năng đối kháng trong việc phòng trị bệnh do nấm gây ra. Nghiên cứu này đã sàng lọc được 11 chủng xạ khuẩn và 10 chủng vi khuẩn có hoạt tính chitinase cao, từ 09 mẫu đất vùng rễ lúa tại tỉnh Kiên Giang. Trong đó, chủng B.KG4.1 và S.KG1.1 có tiềm năng ức chế nấm Pyricularia oryzae mạnh bằng phương pháp đồng nuôi cấy với hiệu suất đối kháng lần lượt đạt 90.9% và 87.41% sau 15 ngày. Hiệu suất đối kháng với nấm Pyricularia oryzae của các chủng vi khuẩn có mối tương quan tỷ lệ thuận với khả năng tiết chitinase ngoại bào của chúng. Dựa trên đặc điểm mô tả hình thái và giải trình tự gen 16S-rRNA, chủng S.KG1.1 được xác định là Streptomyces carpinensis và chủng B.KG4.1 thuộc nhóm Bacillus amyloliquefaciens. Với những đặc điểm trên, Bacillus amyloliquefaciens B.KG4.1 và Streptomyces carpinensis S.KG1.1 có tiềm năng khai thác trong sản xuất chế phẩm chứa các hoạt chất sinh học trong phòng trừ nấm Pyricularia oryzae gây bệnh trên lúa.
Noetherization Theory for a Singular Linear Differential Operator of Higher Order
Authors: Adji Abdourahman Haman
Published: December 2024

Abdourahman Haman Adji
Kredi Karşılıkları ve Teminat Tutarları Tespitinde Sınırda Karbon Düzenlemesi Mekanizması Uygulama Etkisi Model Önerisi: İklim Çarpanı
Authors: Tağtekin Teoman
Published: December 2024

Bu çalışmanın amacı, SKDM- Sınırda Karbon Düzenlemesi Mekanizması kapsamında AB’ne ihracat
yapan işletmelerin kredilendirme sürecinde SKDM etkisinin banka kayıtlarına da finansal boyutta
yansıtılması konusunu inceleyip, alternatif çözüm önerisi sunulmasıdır. SKDM uygulaması, AB’ne
ihracat yapan işletmelerin var olan üretim metodolojilerinde değişikliğe gitmelerini zorunlu kılmış, bu
da ilave maliyete sebep olmuştur. SKDM kapsamında AB’ne ihracat yapan işletmelerin kredilendirme
sürecinde SKDM etkisinin banka kayıtlarına da finansal boyutta yansıması daha gerçekçi olacaktır. Bu
durumu teminen, SKDM etkisinin banka nezdinde oluşan kredi teminat ve karşılık hesaplamalarına
yansıtılması, ek bir mali yük gibi görünse de alınan risk karşısında bankayı olası finansal kayıplara
karşı koruyacak ilave kalkan görevi görecektir. SKDM’nın etkisinin bankalarda oluşan kredi teminat
ve karşılık hesaplamalarına yansıtılması ile ilgili farkındalığın henüz tam olarak oluşmadığı, önerilen
düzenlemenin hayata geçmesi ile birlikte oluşan risk karşısında bankaları olası finansal kayıplara
karşı ekstra bir koruma görevi görebileceği öngörülmektedir. Çalışmanın konusu ile ilgili çalışmaya
rastlanılmadığı için bu çalışmanın sektöre ve bu alana katkıda bulunması beklenmektedir.
Finansal Gelişmişlik ve Derinliğin Ülke Grupları Bağlamında GMM Yöntemi ile İncelenmesi
Authors: Şengül Aykut , Çinko Levent
Published: December 2024

Finansal gelişmişlik, finansal kurumların ve piyasaların etkinliğini, çeşitliliğini ve kapsayıcılığını ifade
ederken, finansal derinlik, finansal varlıkların büyüklüğünün ekonomik büyüklüğe oranı olarak ifade
edilmektedir. Bir ülkede finansal sistemde biriken fonların reel sektöre aktarılarak etkin ve verimli bir
şekilde kullanılabilmesi için finansal gelişmişliğin yanı sıra finansal derinleşme düzeyi de önemli hale
gelmiştir. 1998-2022 dönemini ve 60 ülkeyi kapsayan veri seti ile GMM yöntemi kullanılarak finansal
gelişmişliğin ve finansal derinleşmenin temel belirleyicileri incelenmiştir. Bu kapsamda, tüketici
fiyat endeksi artışı literatüre paralel bir şekilde anılan değişkenleri negatif etkilemekteyken, yatırım
seviyesi, borsa değeri, borsa işlem hacmi, dışa açıklık, reel faiz oranı ve hukuk kuralı endeksinin yukarı
yönlü hareketi söz konusu iki göstergeyi pozitif etkilemektedir. Çalışma finansal derinlik ve finansal
gelişmişliği hem gelişmiş ve gelişmekte olan ülke hem de gelir gruplarına göre ülke sınıflandırılması
ayrımında inceleyerek, sermaye piyasalarının önemini piyasa değeri ve piyasa işlem hacmi bağlamında
ortaya koymaktadır. Sonuç olarak, Türkiye’nin dahil olduğu ülke grupları için en büyük pozitif katkının
yatırım değeri ve piyasa değerinden geldiği görülmektedir
Fraternidade e Ecologia Integral
Authors: Lustosa Lopes Antonio de Lisboa , Fernando Valeque Adamo , Henry Anyine
Published: December 2024

Este estudo examina a encíclica “Laudato Sí'” do Papa Francisco, destacando sua abordagem inovadora e holística sobre as questões ecológicas contemporâneas através do conceito de ecologia integral. Inspirada pelo “Cântico das Criaturas” de São Francisco de Assis, a encíclica coloca a Terra como nossa “casa comum” e enfatiza a interconexão entre todas as formas de vida, promovendo uma visão que abrange dimensões ambientais, sociais, econômicas e culturais. A ecologia integral é apresentada como uma forma de ver e entender a realidade que promove a justiça social, a dignidade humana e o cuidado ambiental. O estudo analisa como a encíclica propõe uma resposta moral e espiritual às crises ecológicas e sociais, instigando uma “conversão ecológica” global. O estudo conclui que a “Laudato Si’” oferece uma contribuição significativa para o discurso ecológico contemporâneo, integrando saberes científicos e teológicos e propondo um caminho para a sustentabilidade e a justiça social. É uma abordagem que busca inspiração no grande movimento espiritual da ecologia integral forjado pelo Papa Francisco ao reconhecer o cuidado com a casa comum como corresponsabilidade intergeracional que expressa a profissão de fé cristã. De tal modo que torna inteiramente relevante a compreensão de que a vida é uma realidade integral e totalmente interligada.
Tudo está interligado
Authors: Godoy Manoel
Published: December 2024

Por diversas vezes, a Campanha da Fraternidade tratou do tema da ecologia. Apesar das críticas de conservadores, as CFs ocupam espaços significativos na mídia nacional e colaboram para formar nova mentalidade a respeito de assuntos que mexem com a conjuntura nacional. Neste artigo, situado no contexto da CF-2025, busca-se refletir sobre algumas relações que rodeiam o tema a ser trabalhado: entre Ecologia Integral e a fraternidade e a amizade social; entre ecologia e política; entre o ecossistema e o fim da vida humana; entre ecologia e inteligência artificial; a passagem do teocentrismo ao antropocentrismo. Tudo isso, com o objetivo de ampliar a reflexão sobre o tema central da CF-2025.
Evangelho da Criação à luz da ecologia integral
Authors: Marques Mariosan de Sousa
Published: December 2024

Este artigo explora a relação entre teologia bíblica e a crise ecológica contemporânea à luz das contribuições exegéticas e da encíclica Laudato Si’ do Papa Francisco. A temática central, que vincula a interpretação dos textos de Gênesis à noção de ecologia integral, é de grande relevância, dado o crescente reconhecimento da crise ambiental como uma questão teológica e ética. A partir de análises comparativas entre os textos bíblicos e as mitologias do Antigo Oriente Próximo, bem como por meio da crítica das fontes e de abordagens sincrônicas da narrativa de criação, o artigo investiga como a tradição judaico-cristã oferece elementos que podem contribuir para uma reconfiguração dos atuais paradigmas de exploração ambiental. Os principais pontos abordados incluem: a adaptação e transformação de conceitos culturais e religiosos do entorno de Israel em seus relatos de criação; a crítica das fontes que diferencia as tradições redacionais sacerdotais e javistas, evidenciando como essas camadas literárias refletem contextos históricos específicos e se relacionam com o cuidado da criação, e  a análise sincrônica que destaca a coesão entre Gênesis 1 e 2-3, propondo uma leitura que enfatiza a responsabilidade humana em relação ao mundo natural. O método de pesquisa utilizado combina a análise exegética, centrada nas abordagens comparativa, diacrônica e sincrônica dos textos bíblicos, com a reflexão teológica baseada na Laudato Si’, integrando aspectos sociais, culturais e espirituais. Ao comparar as diferentes tradições literárias e interpretar o conceito bíblico de “domínio” e “imagem de Deus” à luz da ecologia contemporânea, o artigo busca proporcionar uma releitura dos textos bíblicos que possa dialogar com os desafios ambientais atuais. Na conclusão, argumenta-se que essas abordagens exegéticas, ao ressignificarem a relação entre Deus, a humanidade e a criação, oferecem uma base teológica sólida para uma ética ecológica que não apenas protege o meio ambiente, mas também promove justiça social e espiritual. Dessa forma, os relatos bíblicos de criação, reinterpretados à luz da Laudato Si’, se revelam ferramentas valiosas para a construção de uma consciência ecológica integral.
Perspectivas de los hombres sobre la violencia en espacios universitarios: un abordaje cualitativo
Authors: Kaufmann Nicholas Timothy , Galán Jiménez Jaime Sebastián , Olvera Castillo Carolina , Navarro Sánchez Urenda Queletzú
Published: December 2024

Las instituciones de educación superior mexicanas están alentando cada vez más a los hombres jóvenes a participar en intervenciones preventivas basadas en el género, incluyendo talleres de capacitación y eventos de sensibilización crítica. Sin embargo, se sabe poco sobre las perspectivas de los hombres respecto a los esfuerzos para acabar con el acoso sexual en los campus universitarios. Este estudio cualitativo explora las perspectivas de los hombres con respecto a la seguridad, la violencia sexual y las iniciativas preventivas basadas en el género dentro de una gran universidad estatal en el centro de México. Utilizando datos de grupos focales, el análisis cualitativo presenta temas comunes y divergentes expresados por estudiantes universitarios, profesores y administradores. Los resultados potencializan futuras investigaciones tanto cuantitativas como cualitativas sobre las perspectivas entre hombres acerca de la violencia en espacios universitarios, considerando los factores que la propicien hasta las intervenciones requeridas a nivel institucional para erradicarla.
El podcast como recurso didáctico para el desarrollo de la comprensión y la expresión oral en niños y niñas de 18 a 36 meses
Authors: Figueroa Carvajal Cinthya Alexandra , Loor Santos Patricia Elizabeth , Zambrano Alcívar Johanna Isabel
Published: December 2024

En este artículo investigativo se aborda el problema del bajo desarrollo de la comprensión y expresión oral en niños de 18 a 36 meses en un centro de atención infantil en Ecuador. El objetivo principal fue emplear la figura del podcast como recurso didáctico para mejorar las habilidades lingüísticas. Para el proceso metodológico se empleó un enfoque mixto, utilizando fichas de observación, encuesta y entrevistas a profesionales como técnicas para la recolección de datos. Se implementaron podcasts de cuentos infantiles y se evaluó el nivel de logro en las habilidades lingüísticas de los infantes. Los resultados mostraron mejoras en las habilidades de comunicación intencional, comprensión semántica y capacidad narrativa de los niños. Como resultado se logró identificar que los padres dedican menos de una hora diaria a actividades de desarrollo lingüístico en el hogar. Se concluye que el uso de este recurso didáctico audiovisual, ofrece una alternativa eficaz para estimular el desarrollo lingüístico, subrayando la importancia de integrar herramientas tecnológicas innovadoras en la educación inicial bajo supervisión adecuada.
OMISSIONS IN DRIVING OF A WOMAN - DRIVER, PARTICIPANT IN TRAFFIC ACCIDENTS IN THE AREA OF VALJEVO
Authors:   Basic court in Valjevo: Valjevo, RS, Stojić Biljana
Published: December 2024

Traffic takes place every day, all over the world. People of both sexes and all ages participate in traffic in different ways. The most widespread form of traffic is road traffic because each of us has to leave our home and take a certain number of steps a day. Thus, to participate in traffic. In this paper, through the practice of the Basic Court in Valjevo, some criminal proceedings were analyzed due to criminal acts from the group against public traffic safety in which women drivers participated, against whom criminal proceedings were conducted and their omissions that led to the cause of the traffic accident based on the expertise of by individual traffic technical experts. We believe that the observed omissions will be of importance for a broader analysis of the omissions of women participating in traffic, that with this work new questions of importance are opened not only for traffic safety in Valjevo, the Kolubara district, but also in the territory of the Republic of Serbia as a whole.
Trends and Challenges in Mixed Methods Educational Research
Authors: Zhao Xiantong , Xu Renying
Published: December 2024

The mixed methods research approach combines quantitative and qualitative methodologies to comprehensively understand complex research questions, particularly valuable in educational studies. This study critically examines adopting and utilizing mixed methods in Chinese educational research by analyzing 105 empirical studies published in major Chinese academic databases from 2002 to 2023. Using a framework based on established mixed-methods criteria, researchers evaluated these studies across five dimensions: research objectives, rationale for mixed methods, methodology and sample size, design type, and journal category. The findings reveal that while mixed methods usage in Chinese educational research has grown significantly since 2018, especially with a preference for explanatory sequential and concurrent designs, many studies lack clarity in articulating the rationale behind their methodological choices. This lack of transparency limits the potential of mixed methods to address educational challenges in depth. Additionally, data collection methods remain limited, relying on questionnaires and interviews and less frequently using techniques such as observations and experiments. High-quality journals show a preference for rigorously conducted mixed-methods research, underscoring the importance of methodological rigor. This study advocates for improved alignment of research questions, clearer rationale, and diversified data collection to enhance methodological robustness in future mixed methods educational studies in China.
Research on Development Strategies for Leisure Fishing in Inner Mongolia from the Perspective of Industrial Integration
Authors: Li Xue , Pang Tiantian , Feng Xuebin , Zhang Jianying , Zhao Zhuming
Published: December 2024

This study explores the current status of leisure fishing in Inner Mongolia and its implications for the development of leisure fishing abroad. As an important province in northern China, Inner Mongolia has rich natural resources and unique geographical conditions but still faces many challenges in infrastructure development and ecological protection. By analyzing Inner Mongolia’s unique geographical and climatic conditions, water resource distribution, and industrial structure, the research finds that while the region possesses abundant water resources, inadequate infrastructure and weak awareness of ecological protection remain major constraints on its development. Using the SWOT analysis method, the study identifies the strengths, weaknesses, opportunities, and threats of leisure fishing in Inner Mongolia, highlighting the importance of government policy support and eco-friendly development models in enhancing industry competitiveness. Furthermore, the research proposes strategies to promote industrial chain integration, optimize industrial structure, strengthen infrastructure, implement sustainable development models, and enhance brand building and market promotion. Based on Inner Mongolia’s experience, the study offers insights for developing leisure fishing abroad, recommending a focus on ecological protection and technological innovation, enhancing brand influence, and fostering international cooperation and resource sharing. This research provides a theoretical foundation and practical guidance for developing leisure fishing in Inner Mongolia and other regions, serving as a reference for the sustainable development of global leisure fishing. It emphasizes the necessity of integrated governance and ecological protection while projecting the future prospects for the synergistic development of leisure fishing in economic, environmental, and social dimensions.
Examining the Impact of Interdisciplinary Collaboration among Health Administration, Community Health, Sociology, and Rehabilitation Specialists on Healthcare Quality and Patient Outcomes: A Qualitative Study
Authors: Albeladi Ali Hussain Abdulmohsen , Almubarak Sami Habeeb Ali , Hameed Sana Mansour Yousef , Alsaeed Murtadha Abdullah Abbas , Al Homidan Abdulrhman Abdulaziz Sulaiman
Published: December 2024

Interdisciplinary collaboration in healthcare has gained increasing attention as a means to improve the quality of care and patient outcomes. This qualitative study aims to examine the impact of collaboration among health administration, community health, sociology, and rehabilitation specialists on healthcare quality and patient outcomes. Semi-structured interviews were conducted with 20 healthcare professionals from various disciplines in a large urban hospital. Thematic analysis revealed five main themes: (1) enhanced communication and information sharing, (2) improved care coordination and continuity, (3) increased patient satisfaction and engagement, (4) better management of complex cases, and (5) challenges in implementing interdisciplinary collaboration. The findings suggest that interdisciplinary collaboration can lead to more comprehensive and patient-centered care, but requires supportive organizational structures, clear role definitions, and ongoing training and facilitation. This study highlights the potential benefits and challenges of interdisciplinary collaboration and provides insights for healthcare organizations seeking to improve care quality and patient outcomes.