bluuebunny/crossref_metadata_2025 huggingface dataset:
The Fallacy of Hyaluronic Acid Binding a Thousand Times Its Weight In Water
Authors: Borchers Scott , Pirrung Michael
Published: July 2023

This study re-examined experimental reports and past literature of water binding by the humectant hyaluronic acid, in comparison with another common humectant, glycerol, to critically evaluate the common claim that hyaluronic acid binds a thousand times its weight in water, which makes it especially suited to be a cosmetic moisturizer. Thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to study aqueous solutions of glycerol and hyaluronic acid. A 0.1 weight % aqueous solution of hyaluronic acid is a clear, flowing liquid, comparable to a 10 weight % aqueous solution of glycerol. The melting point and melting heat of fusion for the hyaluronic acid solution were effectively the same as pure water, while both were reduced for the glycerol solution. There is imperceptible freezing point depression by HA, whereas that by glycerol is as expected. No experimental evidence was found for any special ability of hyaluronic acid to bind water at the claimed level of a thousand times by weight. The origin of the fallacy that it binds water at that level can be traced to older literature that has been misunderstood for the meaning of binding, as compared to other physical properties such as hydrodynamics.
Stereochemistry and Total Synthesis of Neonorhalichondrin B
Authors: Quach Rachelle , Aitken Harry , Kishi Yoshito
Published: July 2023

The first total synthesis of neonorhalichondrin B has been completed and the previously undetermined left half sidechain stereochemistry has been elucidated. This was achieved by the initial preparation of a series of stereoisomeric models, leading to a tentative assignment of 49R, 51S, 52S. We then synthesized neonorhalichondrin B incorporating this stereochemistry, confirming our proposed assignment. Highlights of our synthetic sequence include the use of a novel Cu-mediated ketone coupling to prepare the C44 spiroketal, and a Ni(I)/Ni(II)-catalyzed ketone coupling for the final disconnection.
THE IMPACT OF CLASSROOM OBSERVATION IN EARLY EDUCATION ON CHILDREN’S OUTCOMES
Authors: FLORESCU Daniela Mihaela , CIOLAN Laura Elena
Published: July 2023

Educational practices and all that happens in the classroom are essential to children’s learning progress and their development. Despite the importance of teachers’ educational practices, in the low- or middle-income countries the practices are hardly ever measured, partly because of a lack of access to classroom observation tools and the high costs of their administration. As a result, the present research undertook the aim to analyze the improvement of educational practices on the dimensions that are comprised in the observation tool we used: classroom climate, instruction and social and emotional skills by means of classroom observation and providing feedback using the Teach observation tool. Thus, we assume that early childhood education teachers who participate in observation and feedback processes based on the Teach observation tool develop educational practices more adapted to the children’s social and emotional and cognitive needs. The study consisted of conducting a quasi-experiment with three repeated applications of the Teach observation tool on a sample of 19 kindergarten teaching staff. The 19 kindergarten teachers were from the same kindergarten in Braşov city, Kindergarten no.11, “House of joy”. The study was carried out during the 2020-2021 school year. Following the implementation of the Teach observation tool, we can conclude that its role is to facilitate the measurement of quality in early childhood education. Teaching can be a starting point for understanding, measuring and discussing the quality of teaching practices in early childhood education, leading to improved support for teachers and ultimately better learning experiences and higher outcomes for preschoolers. Also, in the future, the Teach observation tool can provide policy makers and stakeholders with the information they need to design and implement policies and programs in early childhood education.
Pelatihan Model Discovery Learning Untuk Meningkatkan Kemampuan Guru Menyusun Kisi dan Soal Hots
Authors: Yuastutik Ida
Published: July 2023

This school action study aims to improve teacher skills in compiling grids and questions at level 3 (based on HOTS). The results of the analysis of academic supervision in 2019 showed that 60% of the teachers in the cluster did not understand well the grid arrangement and level 3 questions to solve problems at school through training with the discovery learning model to be able to manage grids and questions. The research design is School Action Research (PTS). Increased teacher activity in observing the six stages of discovery learning, namely: a) Stage 1 Stimulation; b) Phase 2 Problem Formulation 3 Data Collection; d) Data Processing Stage 4 e) Stage 5 Verification; and f) Stage 6 Generalization. As a result, teacher training activities have increased from cycle I to cycle II as much as 11.34 (11.34%), for the cognitive aspect of teachers who got an A grade as many as 6 teachers (25%), class B as many as 15 teachers (62.5% ), and class C as many as 3 teachers (12,5%). The conclusion is that the use of the Discovery Learning model training can improve teacher training activities and skills in compiling grids and level 3 questions (HOTS) independently.
Pengembangan Media Pembelajaran Matematika Berupa Game Edukasi Berbasis Android Berbantu Software Construct 2
Authors: Armanto Rizki , Netriwati Netriwati , Putra Rizki Wahyu Yunian , Ambarwati Riyama
Published: July 2023

Penelitian ini mengembangkan sebuah media pembelajaran berupa game edukasi berbasis android berbantu software construct 2 pada materi peluang yang digunakan pada peserta didik kelas VIII Sekolah Menengah Pertama (SMP). Metode penelititian yang digunakan adalah RD (research and development) dengan model pengembangan ADDIE yaitu: (1) analysis (Analisis), meliputi: analisis kebutuhan, analisis karakteristik siswa, dan analisis kurikulum, (2) design (Perencanaan), meliputi : pembuatan prototipe, menentukan materi, membuat instrumen, (3) development (Pengembangan), meliputi : pengembangan produk, validasi ahli materi, dan ahli media, (4) implementation (Implementasi), meliputi : uji coba media pada peserta didik, memberikan angket respon, (5) evaluation (Evaluasi). Berdasarkan penilaian yang diberikan oleh para ahli, dapat disimpulkan bahwa desain pembelajaran matematika tingkat SMP dengan software Construct 2 berbasis android memperoleh nilai dari ahli materi yaitu persentase rata-rata sebesar 89% dengan kriteria sangat layak ,dan ahli media 75% dengan kriteria layak. Adapun hasil penelitian respon peserta didik di SMP Amal Bakti dengan uji coba kelompok kecil mendapatkan persentase sebesar 88% dengan kriteria sangat menarik dan uji coba kelompok besar mendapatkan persentse 95% dengan kriteria sangat menarik. Sedangkan uji coba di SMP Negeri 3 Jati Agung pada kelompok kecil mendapatkan persentase 90% dengan kriteria sangat menarik, dan pada uji coba kelompok besar mendapatkan persentase 89% dengan kriteria sangat menarik sehingga produk yang dikembangkan bisa dikategorikan sangat layak dan sudah memenuhi kualifikasi valid untuk digunakan dalam melakukan pembelajaran matematika.Kata Kunci: Construct 2, Game Edukasi, Android, Media pembelajaran.
Personas Desaparecidas, No Localizadas y No identificadas en Reynosa, Tamaulipas, Durante el periodo del 2021 al 2023
Authors: Carmona Mata Myrna Janette , Vargas Orozco Cynthia Marisol , Villarreal Sotelo Karla
Published: July 2023

La Comisión Nacional de Búsqueda de México reportó hasta el mes de noviembre del 2022 que existen 107 mil 192 personas desaparecidas y no localizadas a nivel nacional desde que comenzó el registro en el año de 1964.  Hasta este momento, Jalisco es el estado con mayor número de desaparecidos teniendo una cifra de 15 mil 027 personas, el segundo es el estado de Tamaulipas con 12 mil 405 personas desaparecidas y no localizadas, el Estado de México ocupa el tercer lugar con 11 mil 748 personas. Hablar de Desaparición es hablar de dolor, angustia, temor, delito, crimen, violación de derechos humanos, ausencia, pérdida, inseguridad e injusticia.  Es una familia incompleta, un hogar donde la búsqueda del ausente se ha vuelto eterna para quienes continúan esperando su regreso. En Tamaulipas, además de registrar una de las tasas más elevadas de homicidios en el país, también tiene el segundo lugar nacional de personas desaparecidas. Según en la última actualización en Reynosa, Tamaulipas desaparecen diariamente entre 3 a 6 personas diarias, y esto son cifras con base en los reportes que se hacen mediante la Agencia de Personas No Localizadas, de la Fiscalía general de justicia. Revisado lo anterior se observa la relevancia del tema, en cuanto a conocer las cifras de Personas sin vida que se encuentran en calidad de No Identificadas en el Servicio Médico Forense y las Fosas Ministeriales que se encuentran en Ciudad Reynosa, Tamaulipas.
Análisis Sensorial del Desarrollo una Nieve de Tamarindo con Mermelada de Chile Morrón y Habanero
Authors: Juárez-Valtierra S.L. , Campos-Arroyo D. , Estrada-García S. , Garibay-Rodríguez L.A. , González-Flores S. , Padilla-Vega P.A. , Rodríguez-Vázquez M. , Sombredero-Niño S.C.
Published: July 2023

Los sentidos son la única vía de comunicación del ser humano con su entorno es por ello que mediante el análisis sensorial utilizando dos pruebas se evaluaron tres formulaciones de mermelada en donde la variante en cada una fue el contenido de chile habanero y morrón, para después ser adicionada a tres muestras de nieve de tamarindo cada una con su respectivo código. Mediante el análisis sensorial se determinó la muestra con mayor aceptabilidad de acuerdo con los resultados obtenidos de 39 jueces no entrenados que participaron. La primera prueba fue Prueba de ordenación descriptiva en la cual se evaluó la intensidad de picante de cada muestra, de la cual se obtuvo que no encontraron diferencia significativa entre la muestra de nieve 82705 y 71480. Mientras que en la Prueba de nivel de agrado con escala estructurada, en la cual se evaluó la aceptación en general fue la muestra 66739 (formulación 3), siendo esta la seleccionada para para el desarrollo de este producto. Finalmente, se diseñó el etiquetado del producto con base a la NOM-051-SCFI/SSA1-2010 declarando así el sello de Exceso de azucares en la parte frontal de la etiqueta.
İkinci El Otomotiv Sektöründe Kullanılan Şasi Dinamometrelerinin Ölçüm Doğruluklarının Araştırılması
Authors: YAVUZ İbrahim , ARSLAN Turan Alp , BAYRAKÇEKEN Hüseyin , MUTLU İbrahim , AYSAL Faruk Emre
Published: July 2023

Şasi dinamometreleri motor, güç aktarma organları ve şasi bileşenlerinin test edilmesi amacıyla kullanılmaktadır. Taşıt tipi, boyutları ve ağırlığı gibi temel faktörlerin yanı sıra test cihazı yapısı, yazılımı ve ölçüm yöntemlerine göre sistem üzerinde farklı parametreler incelenebilmektedir. Test sistemi üzerinde kullanılan ekipman ve tasarım yapısına bağlı olarak ölçüm hassasiyeti değişmektedir. Günümüzde ikinci el araç kontrollerinde oto ekspertiz firmaları tarafından yaygın olarak gerçekleştirilen şasi dinamometre testlerinin doğruluğu ve güvenilirliği bir tartışma konusudur. Bu çalışmada, piyasada kullanılan şasi dinamometrelerinin ölçüm doğruluklarının araştırılması için üç farklı taşıt, iki farklı oto ekspertiz firmasında test edilmiştir. Testlerde common rail yakıt enjeksiyonuna sahip, turboşarjlı, Euro 5 emisyon normlarına uygun dizel motora ve manuel vites kutusuna sahip taşıtlar kullanılmıştır. Şasi dinamometrelerinde gerçekleştirilen tüm testlerde belirlenen standart adımlar izlenmiş olup testler basınç ve sıcaklık kaynaklı sapmaların önlenmesi için aynı lokasyondaki firmalarda gerçekleştirilmiştir. Test sonuçlarında taşıtlara ait maksimum güç ve maksimum güç devri, maksimum tork ve maksimum tork devri, ayrıca bu değerlerin fabrika verilerinden sapma miktarları elde edilmiştir. Firmalara ait test sonuçları kendi arasında ve fabrika verileri ile karşılaştırıldığında güç-tork eğrileri, maksimum güç-tork değerleri ve bu değerlerin ortaya çıktığı motor devirlerinde önemli ölçüde sapmalar oluştuğu tespit edilmiştir.
Conceptualization of Money in English and Russian Proverbs
Authors: Oleneva Polina
Published: July 2023

The present article is an attempt to investigate the metaphorical dimension in English and Russian money proverbs. A sample of English and Russian proverbs have been selected from various sources such as dictionaries, previous research, and the internet. The analysis was within the framework of the Conceptual Metaphor Theory as suggested by Lakoff and Johnson (1980), and the force money system by Kövecses (2018). The analysis showed that the money concept in English and Russian proverbs can constitute both the source domain and target domain. Also, it was found that both languages mostly exhibit similarities in the conceptual metaphors that trigger off money proverbs. Nevertheless, In English proverbs, money as a source domain was slightly higher than it is in the Russian proverbs of money. On the contrary, Russian money proverbs showed that money constituted a target domain roughly more than it did in the English proverbs of money. This was an endeavour to explore conceptual metaphors in money proverbs in proverbs in two distinct languages. It is recommended to investigate the metaphors in further areas of proverbs such as health and human relationships between English and Russian.
Sprichwörtliches in der Reformationschronik von Johannes Salat (1498–1561)
Authors: Frech Stephan
Published: July 2023

Die Chronik des Luzerner Gerichtsschreibers Johannes Salat schildert die Anfänge der Schweizer Reformation aus katholischer Sicht. Durch die Weisheit, die Parömien zugesprochen wird, stellt Salat die Vorgänge in einen vorstrukturierten Deutungskontext und bleibt als Chronist unparteiisch. Die Untersuchung will den Gebrauch der Sprichwörter in ihren konkreten Erscheinungsformen aufzeigen: Meist werden sie als sprichwörtliche Redensarten bzw. Phraseme in den Text eingebunden und müssen deshalb syntaktisch angepasst werden. Um sie auf den Kontext abzustimmen, werden sie inhaltlich modifiziert und oft auch ergänzt. An Beispielen wie dem Wolf im Schafspelz soll dargestellt werden, mit welchen Sprachbildern, in denen Sprichwörter und Phraseme zu erkennen sind, der Chronist vor den Gefahren warnt, die aus Sicht eines Altgläubigen von den Lehren Luthers und Zwinglis ausgehen: Versuchung, Vernichtung und Chaos.
„Eine büffelähnliche Stärke einsetzen“
Authors: Lanmadousselo Sewanou Martial Jupiter
Published: July 2023

Von einer Tiermetapher ist die Rede, wenn tierische Eigenheiten auf den Menschen und seine Verhaltensweisen u.a. übertragen werden. Um die Eigenheit und den Charakter der Fon-Sprache zu verdeutlichen, werden in der vorliegenden Studie 37 Fon (Benin)-Ausdrücke exemplarisch ausgewählt. Der Fokus liegt ganz auf der Tiermetaphorik. Die ausgewählten Fon-Redensarten werden zum einen transkribiert und ins Deutsche übersetzt, zum anderen kontextorientiert kommentiert, um ihre semantischen Bedeutungen hervorzuheben. Letzteres wird durch Beispiele erläutert.
Pengembangan Kurikulum Dan Pendekatan Pembelajaran Pendidikan Agama Islam Kontekstual
Authors: Sukino Sukino
Published: July 2023

The Learning Curriculum needs to keep up with the times so the academic texts in it need to be updated. The research explains the concept of curriculum development and Islamic education learning with a contextual approach. This study uses the type of library research (Library Research). This research was conducted by conducting an in-depth analysis of various sources relevant to the issues to be discussed. Data collection was carried out by collecting reference books, scientific journals, and e-book online media information. The results of the study stated that several things such as the curriculum and the development of Islamic education learning must be returned to their philosophical roots with consideration of supporting and inhibiting factors for success. Factors that must be considered are curriculum content, curriculum implementation models, and curriculum evaluation tailored to the needs of students, the world of work, and society. To realize this, PAI teachers must be able to apply a contextual approach by following the principles of constructivist learning, implementing active learning strategies, and using sophisticated technological media and facilities.
Meneladani Karakter Lebah dalam Profesi Akuntan Manajemen
Authors: Sudarini  , Sawarjuwono Tjiptohadi , Rahmiati Alfa
Published: July 2023

The pressure experienced by a management accountant tends to make him commit unethical behavior, especially financial report fraud. This causes a decrease in the quality of decision making by parties who have an interest in both management and third parties. This study used interpretive analysis and triangulation methods of in-depth interviews of a management accountant and observations who revealed that the characteristics of bees are hardworking, trustworthy, sincere and willing to sacrifice, disciplined, obedient and obedient, independent, not seeking positions, respecting leaders, beneficial to other beings. and maintaining cleanliness provides a handle for management accountants. The ethics of management accountants integrity, objectivity, competence and professional due care, confidentiality and professional behavior are in line with the character of bees. The bee characters used in this study come from Putra and Nurhadi, 2020, p. 139-192 and Jayana, 2016, p. 109-147.
FORMS OF COMMUNITY PARTICIPATION IN THE DEVELOPMENT OF THE TOURIST VILLAGE OF GENGGELANG, NORTH LOMBOK DISTRICT
Authors: Intan Intan Maharani Asmara , Sri Susanty  , Rizal Kurniansah
Published: July 2023

The problems studied in this research are related to the development of the Genggelang Tourism Village, North Lombok Regency regarding the forms of participation carried out by the community. The research method used is descriptive with a qualitative approach conducted in Genggelang Tourism Village, North Lombok Regency. Data collection techniques were observation, interviews, and documentation with informants including the Penjor Hamlet Pokdarwis, Kertaraharja Hamlet Pokdarwis, and Gangga Hamlet Pokdarwis. Data analysis uses Miles and Hubermen (1992) where data analysis is carried out interactively and takes place continuously until the data obtained becomes complete. The results of this study indicate that the form of community participation is divided into 4 forms of participation, namely the participation of money, property, labor, and skills. This form of community participation is carried out based on supporting and inhibiting factors in the Genggelang Tourism Village. supporting and inhibiting factors are divided into 3 hamlets. Where each of these hamlets has a tourist destination. So the form of community participation in Genggelang Tourism Village is also divided into each of the related hamlets. The information contained in this paper is expected to be able to assist in increasing community participation in the Genggelang Tourism Village, North Lombok Regency.
AVAILABILITY OF TOURISM COMPONENTS IN LANTAN VILLAGE, CENTRAL LOMBOK DISTRICT, INDONESIA
Authors: Alievia Alievia Putri Namira , Rizal Kurniansah  , Baiq Yatni Milana Putri  , Arif Ismawan
Published: July 2023

Lantan is one of the villages located in North Batukliang District, Central Lombok Regency, West Nusa Tenggara Province, Indonesia. Lantan Village also borders several other villages, namely the north bordering the Protected Forest Area, the south with Aik Darek Village, the west with Karang Sidemen Village and Tanak Beak Village and the east bordering Aik Berik Village, Teraktak Village and Selebung Village. To make Lantan village a tourist village, an initial study is needed to determine its potential. This research is qualitative research, the data collection methods used are observation, interviews, documentation and literature study. Based on the results of the research that has been done The tourist attraction is Elong Tune Waterfall, besides being able to enjoy Elong Tune waterfall, tourists can also enjoy other supporting facilities at that location including taking pictures, relaxing in the barracks and playing swings. In addition, access to the location is feasible and in good condition. Other facilities in the Lantan tourism village are public toilets and barugak. Finally, ancillary services where in the Lantan tourist village there is a Pokdarwis as the manager of the Lantan tourist village.
Identifying the Accuracy and Comprehensibility of Students’ English Word By Word Pronunciation at North Lombok Senior High School
Authors: Irwan Muhamad , Wilian Sudirman , Arafiq Arafiq , Amin Muhammad
Published: July 2023

Pronunciation is an important component of language learning that must be well mastered in order to support the development of students' competence in language skills, particularly speaking skills. This descriptive research aims to evaluate the accuracy and comprehensibility of English pronunciation among tenth-grade IPS students consisting of 30 students at SMAN 1 Bayan in North Lombok. Qualitative methods were employed, using student voice recordings as primary data and relevant documents as secondary data. The data analysis technique in this study uses the concept of qualitative data analysis developed by Miles and Huberman in (1994), including data reduction, data display and conclusions drawing. The results showed that while some students demonstrated excellent proficiency in English pronunciation, others faced significant challenges in accurately articulating vowel and consonant sounds. These findings highlight the importance of targeted interventions to support struggling students and improve the pronunciation skills of all students. The research questions are focused on the accuracy and comprehensibility of English pronunciation among students in North Lombok. Through our evaluation, we found that the level of accuracy in common words varied among students, with some struggling to pronounce even basic words accurately.
PENGARUH KUALITAS PELAYANAN TERHADAP MINAT BERKUNJUNG KEMBALI KE DESA WISATA HIJAU BILEBANTE YANG DIMEDIASI OLEH KEPUASAN WISATAWAN
Authors: Riadi Didi , Permadi Lalu Adi , Retnowati Weni
Published: July 2023

Abstrak: Penelitian inibertujuan untuk mengetahui lebih jauh tentang pengaruh kualitas pelayanan (X) terhadap minat berkunjung kembali (Y), pengaruh kualitas pelayanan (X) terhadap kepuasan wisatawan (Z) dan pengaruh kepuasan wisatawan (Z) terhadap minat berkunjung kembali(Y) ke Desa Wisata Hijau Bilebante. Responden pada penelitian ini berjumlah 100 wisatawan. Jenis penelitian yang digunakan adalah asosiatif kausal dengan pendekatan kuantitatif. Metode pengumpulan data yang dugunakan adalah sampel survey menggunakan angket dan online survey melalui kuesioner. Teknis analisis yang digunakan adalah analisis statistik deskriptif, uji asusmsi klasik, uji hipotesis dan analisis jalur. Hasil penelitian ini menunjukkan bahwa (1) kualitas pelayanan berpengaruh positif dan signifikan terhadap minat berkunjung kembali ke Desa wisata hijau Bilebante. (2) kualitas pelayanan berpengaruh positif dan signifikan terhadap kepuasan wisatawan ke Desa wisata hijau Bilebante. (3) kepuasan wisatawan berpengaruh positif dan signifikan terhadap minat berkunjung kembali ke Desa wisata hijau Bilebante.

Abstract: This study aims to find out more about the effect of service quality (X) on interest in revisiting (Y), the effect of service quality (X) on tourist satisfaction (Z), and the effect of tourist satisfaction (Z) on interest in revisiting (Y) at Bilebante Green Tourism Village. The respondents in this study amounted to 100 tourists. The type of research used is causal-associative with a quantitative approach. The data collection methods used are a sample survey using a questionnaire and an online survey through a questionnaire. The technical analysis used is descriptivestatistical analysis, classical assumption tests, hypothesis testing, and path analysis. The results of this study indicate that (1) service quality has a positive and significant effect on interest in visiting Bilebante's green tourism village. (2) Service quality has a positive and significant effect on tourist satisfaction in the Bilebante green tourism village. (3) Tourist satisfaction has a positive and significant effect on interest in visiting Bilebante's green tourism village.
Radne orijentacije, smisao posla, profesionalni identitet i zadovoljstvo odgojitelja
Authors: Jurčević Lozančić Anka
Published: July 2023

Suvremeni društveni kontekst u kojem poslovi odgojitelja postaju zahtjevniji, a oni istodobno profesionalno i statusno marginalizirani u našem društvu, zadovoljstvo poslom i profesionalno djelovanje odgojitelja nameće se kao važno istraživačko područje. S obzirom na to da u Republici Hrvatskoj (i u svijetu) nedostaju istraživanja o zadovoljstvu poslom odgojitelja, a vođeni saznanjem da je značajno povezano s kvalitetom odgojno-obrazovnoga rada, time i unaprjeđivanjem razvoja djece rane i predškolske dobi i njihovih postignuća, ovim radom želi se promovirati profesija odgojitelja. Istraživanjem je obuhvaćeno ukupno 536 odgojitelja. Da bi se ispitalo profesionalno djelovanje i zadovoljstvo poslom, u istraživanju su primijenjene sljedeće skale: Upitnik radnih orijentacija, Skala zadovoljstva životom, Zadovoljstvo poslom, Skala smislenosti posla te Skala profesionalne identifikacije. Za potrebe ovoga istraživanja izračunana je jednostavna deskriptivna statistika na skalama, matrica korelacije u koju su uključene i relevantne sociodemografske varijable te je provedena analiza varijance. Rezultati istraživanja pokazuju da odgojitelji primarno svoj posao smatraju pozivom te da svojim radom i profesionalnim djelovanjem daju svoj doprinos društvu, a iz istih je rezultata vidljivo da odgojitelji koji rade uglavnom zbog osobnoga dohotka osjećaju posao kao nužnost, postižu u prosjeku niže rezultate na skali zadovoljstva poslom i životom, vlastiti posao smatraju manje smislenim i ne identificiraju se značajno s njim.
»Do not rush like geese into fog!«. Critical analysis of the discourse of a political leader’s speech on the example of Stjepan Radić’s speech from 24/25 November 1918 in the National Council
Authors: Novoselac Veronika , Smiljanić Vlatko
Published: July 2023

Political discourse is a set of all speech acts that are determined and articulated in the form of verbal formations, whereby their content, subject and addressee fall under the purview of politics. Using Van Dijk’s model of critical discourse analysis, the paper demonstrates one of the possibilities of an integrated approach to qualitative research in historiography using Radić’s most famous speech as an example, which has not yet attracted the attention of communication studies and historiography to be adequately analyzed, interdisciplinarily evaluated, and syncretistically interpreted.
Tumor cell-intrinsic expression of BTLA, ICOS and TIGIT in human breast cancer.
Authors: Mamoor Shahan
Published: July 2023

We recently described primary tumor expression of BTLA (B and T lymphocyte associated), ICOS (inducible T-cell costimulator) and TIGIT (T-cell immunoreceptor with Ig and ITIM domains) in the tumors of patients with breast cancer (1-3), but expression of CD28/CTLA4 family receptors (4, 5) by cells of the tumor rather than by tumor-infiltrating immune cells is not well understood. We used published (6) whole transcriptome data from laser capture microdissection-isolated tumor cells (rather than bulk tumor) and describe primary tumor cell-intrinsic expression of BTLA, ICOS and TIGIT in patients with triple negative breast cancer.
Epidemio-clinical profile of patients who underwent myomectomy in two first-level hospitals in the city of Douala, Cameroon
Authors: Guy Ekono Michel Roger , Junie NgahaYaneu , Félix Elong Adolphe , Gambo AminatouYababba Moussa , Charlotte TchenteNguefack
Published: July 2023

Introduction: The aim of this study was to describe the epidemiological-clinical profile of patients who underwent myomectomy by laparotomy in two first-level hospitals in the city of Douala, Cameroon. Methods: This was a retrospective descriptive study including the records of patients who underwent myomectomy by laparotomy from January 1, 2012 to December 31, 2020 at the General Hospital and the Gyneco-Obstetrics and Pediatric Hospital of Douala. Epidemiological, clinical and paraclinical data were collected. The results were analyzed using SPSS version 25 and Microsoft Excel 2016 software. Results: A total of 204 patients were enrolled. The mean age was 37.02±4.9 years. The nulliparous and the infertile respectively represented 68.1 and 66.7% of the participants. Abnormal bleeding (68.2%) was the most common reason for consultation. Anemia affected 72.1% of patients. Overweight and obesity were found respectively in 34.8 and 31.9% of patients. More than 7 out of 10 patients had a uterus larger than 16 weeks of amenorrhea. 4.40 cm. Interstitial and submucosal myomas involved respectively 82 and 53% of patients. Endometrial polyps were associated in 28.6% of explored cases. Conclusion: Myomectomy is performed in relatively elderly patients, consulting for abnormal bleeding, and associating infertility, overweight, and anemia. They present a large uterus, comprising voluminous myomas, mainly interstitial, but also submucosal, which can coexist with polyps, hence the interest of hysterosonography.
Frequency of vaginitis types based on Pap smear test in patients referred to the gynecology clinic of Shahid Sadoughi hospital in Yazd
Authors: Ayatollahi Jamshid , Babadi Azar Faramarzi , Hajisafari Mojgan , Fallah Tahere , Shahcheraghi Seyed Hossein
Published: July 2023

Three agents including candida, trichomonas and bacteria, are the main causes of vaginitis. According to studies conducted in Iran and other parts of the world on the increase of vaginal infections, the present study was conducted to evaluate the frequency of vaginitis based on Pap smear in patients referred to the gynecology clinic of Shahid Sadoughi hospital in Yazd, Iran. The sampling method was census and all cases referred to the gynecology clinic of Shahid Sadoughi hospital in Yazd for Pap smear during 2022 were investigated. Finally, the data were entered into SPSS and analyzed. 378 patients (45%) had vaginitis. According to the results of the study, no statistically significant difference was found between the frequency distribution of vaginitis based on age, dyspareunia, frequency of urination, dysuria and education level. The results of the present study showed a high prevalence of bacterial vaginitis compared to other types of vaginitis.
The university without walls
Authors: Parker Martin
Published: July 2023

My concern in this article is how the university might become more distributed, less concentrated in particular places and times, and more permeable to different sorts of interests. In order to do this, I have written a partly autobiographical reflection on an attempt to practice the work of the university differently. It is the early story of a sort of ‘research institute’ which is attempting to take the problems of its city region seriously and find ways to connect the resources of a large elite university to many other organisations in its locality. In theoretical terms, the article uses the idea of ‘social infrastructure’ as a way of thinking about how an institution operates beyond its imagined temporal and spatial boundaries and co-produces with people who have different identities and capacities.
An approach to the background, methods and challenges of research in disasters
Authors: Arcos González Pedro , Cernuda Martínez José Antonio
Published: July 2023

Disasters are phenomena of global distribution and increasing impact, with a social and interdisciplinary nature and that often require the use of quantitative and qualitative methods to be investigated. The purpose of this paper is to explore the historical background of disaster research, the current use of epidemiological methods in disasters, as well as the difficulties and future challenges of research in this field.

This study considers bibliographic elements and specific non-bibliographic events that have determined the historical evolution of disaster research, as well as its conceptual framework, particularly in relation to the approaches from which the research has been carried out and the range of methods epidemiological used. This is not a standard review.

Current disaster research is developed for a wide variety of purposes, including the identification and characterization of populations exposed or at risk of disaster; the study and establishment of the exposure model for each specific type of disaster; the estimation of the incidence and prevalence of the different types of disaster and the quantification of the impacts in the short, medium and long term. Research is also carried out in the field of disasters to assess needs, plan relevant and efficient types of aid; model and predict the occurrence and to design adequate and efficient prevention, preparedness, mitigation and rehabilitation strategies.

Even so, the predominant research on disasters is still very much focused on certain partial aspects of the phenomenon such as the response to the disaster and directed towards specific types of disasters, especially those of rapid onset. There is still little multidisciplinary and collaborative research among researchers from the different areas of interest that constitute the disaster phenomenon.

Important challenges persist in disaster research, including the design of a common conceptual framework that allows multidisciplinary research in disasters, the development of specific methods to investigate complex emergencies (complex humanitarian emergencies) or disasters related to climate change; the development of a specific approach to investigate slow-onset disasters and their social, political and cultural factors, as well as research to develop feasible and cost-efficient prevention and response strategies. Solving these challenges will depend to a large extent to which the investigative capacity of managers and heads of organizations and field personnel working in disasters is improved.
Democratic Liberal Theory Based on Literature Review
Authors: Iskandarsyah Siregar
Published: July 2023

Since the emergence of the application of the idea of democracy as the system of choice, various groups have complained about the evil practices of democratic politics. One of the shooting targets is that we choose the wrong one, namely adopting the model of the majority or liberal democracy. In the literature on democratic theory, one of the relevant theories for improving democratic practice is TDD (Theory of Deliberative Democracy). Although still using the principle of representation, TDD in general makes corrections or improvements to the procedures and substance of democracy which have so far been poorly practiced in Indonesia. This research is qualitative research using a descriptive-analytic method to provide a clear picture of the object of the problem. The conclusion of this study shows evidence of the existence of a democratic model both in substance and procedure. In contrast to the representative mechanism which was originally derived from the theory of representative democracy. There is visible hypocrisy and inconsistency in the implementation of democracy, which has never been considered a complete system.
Efectos de la vacuna contra el COVID-19 en mujeres embarazadas
Authors: Yunga Carchi Kelvin Hernán , Guerrero Cevallos Esteban Rigoberto
Published: July 2023

Introducción. Las mujeres que se encuentran embarazadas tienen mayor probabilidad de desarrollar un estado más grave de COVID-19 debido a cambios fisiológicos que experimentan, al contrario de las mujeres no gestantes, por lo que la seguridad de las vacunas en esta población es una preocupación constante a pesar de que la Organización Mundial de la Salud y los gobiernos de diferentes países han permitido la aplicación de las vacunas en mujeres gestantes, la información sobre su seguridad son diversas pero no del todo confiables, aunque en ciertos estudios han demostrado que es una estrategia segura con una alta eficiencia tanto a nivel materno como en el feto en contra el COVID-19 aún se espera su evolución a largo plazo. Objetivo. Describir los efectos de la vacuna contra el COVID-19 en mujeres embarazadas a partir de una revisión bibliográfica. Metodología. Es una revisión de tipo bibliográfica en donde se utilizó la base de datos PubMed con artículos en el idioma inglés y español en los últimos tres años utilizando términos DeCS y MeSH como también los booleanos AND y OR incorporando criterios de inclusión y exclusión con la finalidad de tener una búsqueda más específica. Resultados. Se evidencia que posterior a la aplicación de la vacuna contra el COVID-19 además de reducir la severidad de la enfermedad y el riesgo de hospitalización, se tiene un protección materno-fetal compartida que aumenta con dosis de refuerzo en especial cuando se aplica antes de las últimas semanas de embarazo. Los efectos secundarios más comunes fueron fatiga, dolor de cabeza, mialgia, escalofríos, náuseas, vómitos, dolor articular y fiebre, en cuanto al trimestre más adecuado para la aplicación de vacuna esta se mantiene en debate. Conclusión. La vacuna contra el COVID-19 es eficaz para que las mujeres embarazadas se protejan contra la forma grave producida por COVID-19, la seguridad de las vacunas es evidentes al igual que la presencia de efectos secundarios que pueden ir dese locales hasta sistémicos.
Free Vibrational Analysis of Non-uniform Double Eulerbernoulli Beams on a Winkler Foundation Using Laplace Differential Transform Method
Authors: Usman M A , Hammed F A , Daniel D O
Published: July 2023

In this study, the free vibrational analysis of non-uniform Euler-Bernoulli double beams on a Winkler foundation under simply supported and fixed-fixed boundary conditions is examined. The governing equation is solved using the Laplace Differential Transform Method, the combined form of the Laplace transform and differential transform technique (DTM). The accuracy of the method used is demonstrated by comparing the natural frequencies obtained using LDTM with previously published results available in the literature. It is discovered that for non-uniform double Euler-Bernoulli beams on a Winkler foundation with fixed-fixed end conditions, the natural frequencies are higher than those of simply supported end conditions. It is also observed that as the non-uniformity of the cross section of the beam increases, the natural frequencies reduce. Hence, it is suggested that the non-uniformity of the cross-section of the beam for a simply supported end condition be between 0 and less than 0.8. While the fixed-fixed end condition should have a value between 0 and 0.95.
Journal of Engineering Science 14(1), 2023, 111-121
Digital tools and social-ecological sustainability. Going beyond mainstream ways of understanding the roles of tools in contemporary eduscapes
Authors: Almén Lars , Bagga-Gupta Sangeeta
Published: July 2023

All education in Sweden, or the Swedish eduscape, is permeated by discourses of compensation and inclusion, conceptualized in this study as a one-school-for-all ethos or perspective. This ethos contributes to a social-ecological framing, wherein the intentions are a society where everyone can participate as active members. This study scrutinizes the governmental strategy of 2017 to digitalize the Swedish educational system based on a one-school-for-all perspective. The study is framed by SWaSP (Second Wave of Southern Perspective) theoretical ideas, with a special focus on positionings, languaging, timespaces, and epistemological-methodological dimensions, including ethics based on the entangled tenets of sociocultural, integrationist, and southern perspectives. Furthermore, this study is anchored in three research projects and one societal developmental project. Materials - e.g., video recordings, audio recordings, photos, artifacts, fieldnotes – from these projects have been generated through (n)ethnographic methods from different institutions in the Swedish educational landscape i.e., eduscape. These span across compulsory schools to Swedish for Immigrants (SFI), within Municipal Adult Education. Three themes have emerged in the multi-scalar data analysis from across settings: (i) intended inclusion, (ii) unintended exclusion, and (iii) intended exclusion. The first theme highlights how digital tools (DTs) create inclusion for students with special needs, or those who are new to the named-language Swedish, in the classroom community, thus contributing to social-ecological sustainability. The second theme illustrates how DTs intended for inclusion in classroom practices morph into tools of exclusion for individuals in mainstream classrooms. The third theme highlights how students in the Swedish eduscape are intentionally excluded from mainstream classrooms. We argue that a social-ecological sustainable stance troubles the division of eduscapes into “mainstream” and “other” settings in contemporary societies, calling for the inclusion of all students irrespective of their positionalities. Our findings highlight that multimodal use of DTs potentially can facilitate inclusion, by providing tools where individual students can participate in and contribute to teaching and learning—what we frame as a third position of classroom organization.
Microbial metabolite p-cresol inhibits gut hormone expression and regulates small intestinal transit in mice
Authors: Toft Pernille Baumann , Vanslette Amanda Marie , Trošt Kajetan , Moritz Thomas , Gillum Matthew Paul , Bäckhed Fredrik , Arora Tulika
Published: July 2023

p-cresol is a metabolite produced by microbial metabolism of aromatic amino acid tyrosine. p-cresol and its conjugated forms, p-cresyl sulfate and p-cresyl glucuronide, are uremic toxins that correlate positively with chronic kidney disease and diabetes pathogenesis. However, how p-cresol affects gut hormones is unclear. Here, we expose immortalized GLUTag cells to increasing concentrations of p-cresol and found that p-cresol inhibited Gcg expression and reduced glucagon-like peptide-1 (GLP-1) secretion in vitro. In mice, administration of p-cresol in the drinking water for 2 weeks reduced the transcript levels of Gcg and other gut hormones in the colon; however, it did not affect either fasting or glucose-induced plasma GLP-1 levels. Furthermore, it did not affect glucose tolerance but promoted faster small intestinal transit in mice. Overall, our data suggest that microbial metabolite p-cresol suppresses transcript levels of gut hormones and regulates small intestinal transit in mice.
Comparison of humoral and cellular immune responses in hematologic diseases following completed vaccination protocol with BBIBP-CorV, or AZD1222, or BNT162b2 vaccines against SARS-CoV-2
Authors: Szabó Enikő , Modok Szabolcs , Rónaszéki Benedek , Faragó Anna , Gémes Nikolett , Nagy Lajos I. , Hackler László , Farkas Katalin , Neuperger Patrícia , Balog József Á. , Balog Attila , Puskás László G. , Szebeni Gabor J.
Published: July 2023

Background

Vaccination has proven the potential to control the COVID-19 pandemic worldwide. Although recent evidence suggests a poor humoral response against SARS-CoV-2 in vaccinated hematological disease (HD) patients, data on vaccination in these patients is limited with the comparison of mRNA-based, vector-based or inactivated virus-based vaccines.

Methods

Forty-nine HD patients and 46 healthy controls (HCs) were enrolled who received two-doses complete vaccination with BNT162b2, or AZD1222, or BBIBP-CorV, respectively. The antibodies reactive to the receptor binding domain of spike protein of SARS-CoV-2 were assayed by Siemens ADVIA Centaur assay. The reactive cellular immunity was assayed by flow cytometry. The PBMCs were reactivated with SARS-CoV-2 antigens and the production of activation-induced markers (TNF-α, IFN-γ, CD40L) was measured in CD4+ or CD8+ T-cells ex vivo.

Results

The anti-RBD IgG level was the highest upon BNT162b2 vaccination in HDs (1264 BAU/mL) vs. HCs (1325 BAU/mL) among the studied groups. The BBIBP-CorV vaccination in HDs (339.8 BAU/mL ***p < 0.001) and AZD1222 in HDs (669.9 BAU/mL *p < 0.05) resulted in weaker antibody response vs. BNT162b2 in HCs. The response rate of IgG production of HC vs. HD patients above the diagnostic cut-off value was 100% vs. 72% for the mRNA-based BNT162b2 vaccine; 93% vs. 56% for the vector-based AZD1222, or 69% vs. 33% for the inactivated vaccine BBIBP-CorV, respectively. Cases that underwent the anti-CD20 therapy resulted in significantly weaker (**p < 0.01) anti-RBD IgG level (302 BAU/mL) than without CD20 blocking in the HD group (928 BAU/mL). The response rates of CD4+ TNF-α+, CD4+ IFN-γ+, or CD4+ CD40L+ cases were lower in HDs vs. HCs in all vaccine groups. However, the BBIBP-CorV vaccine resulted the highest CD4+ TNF-α and CD4+ IFN-γ+ T-cell mediated immunity in the HD group.

Conclusion

We have demonstrated a significant weaker overall response to vaccines in the immunologically impaired HD population vs. HCs regardless of vaccine type. Although, the humoral immune activity against SARS-CoV-2 can be highly evoked by mRNA-based BNT162b2 vaccination compared to vector-based AZD1222 vaccine, or inactivated virus vaccine BBIBP-CorV, whereas the CD4+ T-cell mediated cellular activity was highest in HDs vaccinated with BBIBP-CorV.
Dose–response relationship between multiple trace elements and risk of all-cause mortality: a prospective cohort study
Authors: Zhao Shaohua , Wang Shaohua , Yang Xiaorong , Shen Lin
Published: July 2023

Objectives

We aimed to prospectively investigate the independent and combined relationship between trace elements concentrations [blood (selenium, manganese), serum (copper, zinc), and urine (cobalt, molybdenum, tin, strontium, iodine)] and all-cause mortality.

Methods

This study included 5,412 individuals with demographical, examination, and laboratory data from the National Health and Nutrition Examination Survey. Three statistical models, including Cox proportional hazards models, restricted cubic spline models, and Bayesian kernel machine regression (BKMR) models, were conducted to estimate the longitudinal relationship between trace elements and all-cause mortality.

Results

There were 356 deaths documented with a median follow-up time of 70 months. In the single-exposure model, the results showed that compared with the lowest quartile, the adjusted hazard ratios (HRs) of mortality for the highest quartile of selenium, manganese, and strontium were 0.47 (95% CI: 0.28–0.79), 1.57 (95% CI: 1.14–2.14), and 0.47 (95% CI: 0.26–0.86), respectively. A nonlinear relationship between zinc, cobalt and mortality was also observed. Furthermore, a significant overall effect of mixtures of trace elements on all-cause mortality was identified, especially when the mixture was at the 60th percentile or lower.

Conclusion

The association of multiple trace elements with all-cause mortality was identified in this study. It is recommended that healthcare providers and relevant public health agencies should strengthen the surveillance and management of trace elements. Emphasis should be placed on monitoring the sources of trace elements such as the body, food, and environment. More population studies and animal experiments should be conducted to identify the underlying mechanisms.