bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of the ongoing pregnancy rate with Progesterone Vaginal Gel 180 mg/d vs. Progesterone Vaginal Gel 90 mg/d combined with oral dydrogesterone for luteal phase support in frozen-thawed embryo transfer cycles in Chinese women: A pilot randomized study
Authors: Li Na , Fan Lijuan , Mu Xin , Wang Rui , Cai He , Bian Geyan , Yang Chen , Shi Wenhao , Shi Juanzi
Published: January 2024

Background
The preferred modality of progesterone for luteal phase support in Western countries and China is different. This study investigated two different programs of Progesterone Vaginal Gel for frozen-thawed embryo transfer (FET) in terms of pregnancy outcomes.
Methods
This single-center, randomized pilot trial (ChiCTR2000034113) enrolled women 20–40 years old with endometrial thickness > 8mm, and at least two good-quality blastocysts. All participants received a gonadotropin-releasing hormone agonist for their first frozen-thawed single blastocyst transfer and hormonal replacement therapy (HRT) for endometrial preparation. The participants were 1:1 randomized to Progesterone Vaginal Gel 90mg bid vs. Progesterone Vaginal Gel 90mg qd combine oral Dydrogesterone10mg bid after blastocyst transfer. The primary outcome was the ongoing pregnancy rate at 12 weeks of gestation. Safety was evaluated using patient-reported outcomes.
Results
Ninety-seven and ninety-nine participants completed the study in the Progesterone Vaginal Gel 180mg/d and 90mg/d groups, respectively. There were no statistically significant differences between the two groups regarding the ongoing pregnancy rate at 12 weeks of gestation (57.73% vs. 65.66%, OR 1.40, 95% [CI] 0.79–2.50, P = 0.2544). The positivity, clinical pregnancy, early abortion, late abortion and ectopic pregnancy were comparable between the two groups (all P > 0.05), as well as the live birth and premature birth rate. There were no statistically significant differences in the patient-reported safety outcomes between the two groups (all P > 0.05), and no severe adverse events or adverse events leading to study termination occurred.
Conclusion
This study preliminarily showed comparable ongoing pregnancy rates and similar safety profile with Progesterone Vaginal Gel 180mg/d compared to Progesterone Vaginal Gel 90mg/d plus oral dydrogesterone tablets for luteal phase support in FET, which need to be further verified due to the limitation of the pilot design.
Uniformly dispersed ruthenium nanoparticles on porous carbon from coffee waste outperform platinum for hydrogen evolution reaction in alkaline media
Authors: Sukhbaatar Bayaraa , Qing Wang , Seo Jinmyeong , Yoon Sanghwa , Yoo Bongyoung
Published: January 2024

Biowaste-derived carbon materials are a sustainable, environmentally friendly, and cost-effective way to create valuable materials. Activated carbon can be a supporting material for electrocatalysts because of its large specific surface area and porosity. However, activated carbon has low catalytic activity and needs to be functionalized with heteroatoms, metals, and combinations to improve conductivity and catalytic activity. Ruthenium (Ru) catalysts have great potential to replace bench market catalysts in hydrogen evolution reaction (HER) applications due to their similar hydrogen bond strength and relatively lower price. This study reports on the synthesis and characterizations of carbon-supported Ru catalysts with large surface areas (~1,171 m2 g-1) derived from coffee waste. The uniformly dispersed Ru catalyst on the porous carbon has excellent electrocatalytic activity and outperformed the commercial catalyst platinum on carbon (Pt/C) toward the HER. As-synthesized catalyst needed a 27 mV to reach a current density of 10 mA cm−2, 58.4 mV dec-1 Tafel slope, and excellent long-term stability. Considering these results, the Ru nanoparticles on coffee waste-derived porous carbon can be utilized as excellent material that can replace platinum-based catalysts for the HER and contribute to the development of eco-friendly and low-cost electrocatalyst materials.
EBV Infection as a Risk Factor for SLE Development in Adult Sudanese Patients: A Case‒Control Study
Authors: Gamil Sahar , Mohamed Hala K. A. , Mohamed Abdelrahim O. , Alagib Alnour
Published: January 2024

Background
To evaluate Epstein–Barr virus (EBV) infection as a risk factor for the development of systemic lupus erythematosus (SLE) in Sudanese patients. This was a case‒control study. Forty-two SLE patients and forty-one age- and sex-matched controls were included. Demographic, clinical and laboratory data were collected. Venous blood samples were drawn, and EBV-viral capsid antigen (EBV-VCA) IgG titre levels were quantified. Demographic, clinical and laboratory data were compared between the two groups by either Student’s t test or the Mann‒Whitney U test for continuous data or by χ² analysis for categorical data. P values < 0.05 were considered to indicate statistical significance.
Results
The SLE patients in the present study had a low mean Hb concentration (11.5 ± 1.7 gm/dL) and a low RBC count (4.1 ± 0.73). Almost all patients (41, 97.6%) and controls (40, 97.6%) were positive for VCA-IgG (P = 0.99). The titre levels of VCA-IgG between the two groups were similar (153.8 ± 58.2 RU/ml for patients, 156.6 ± 64.1 RU/ml for control groups; p = 0.83). The mean EBV-VCA-IgG levels were similar between the positive and negative anti-dsDNA patients, with a p value of 0.98. The mean VCA-IgG titre was also similar between anti-Sm-positive and anti-Sm-negative patients (p = 0.22).
Conclusions
No association was found between EBV infection and SLE development in adult Sudanese patients. A larger sample size and younger population are recommended to elucidate any associations between EBV and SLE.
Thiol-Disulfide Homeostasis in Autosomal Dominant Polycystic Kidney Disease: A Cross-Sectional Cohort Study
Authors: Elcioglu Omer Celal , Koktasoglu Fatmanur , Ozturk Burak Baris , Aris Özlem , Mirioglu Safak , Gursu Meltem , Selek Sahabettin , Kazancioglu Rumeyza
Published: January 2024

Background: Oxidative stress (OS) is implicated in the pathogenesis of various chronic inflammatory diseases, including polycystic kidney disease (PKD). While there are indications of OS involvement in PKD development, conclusive evidence is lacking. This study aimed to investigate Thiol-disulfide homeostasis (TDH), a closely related marker to OS, in PKD patients with different renal functions.
Methods: A cross-sectional cohort study included 140 participants divided into four groups: ADPKD with eGFR > 60 ml/min/1.73m2 (PKD), ADPKD with eGFR < 60 ml/min/1.73m2 (PKD_CKD), chronic kidney disease unrelated to diabetes or ADPKD (CKD), and healthy controls (HC). Serum for TDH evaluation was collected after an 8-hour fast. Routine metabolic parameters were assessed, and TDH parameters were determined using the automated photometric Erel method.
Results: No significant differences were observed between groups in age, sex, BMI, and smoking, except the PKD group had a significantly higher proportion of males than the other groups. Serum TTHIOL and NTHIOL levels were significantly higher in PKD_CKD compared to CKD (p=0.001 and p<0.001, respectively). Serum disulfide values showed no significant differences between PKD_CKD and CKD (p=0.464) or between PKD and HC (p=0.279).
Conclusions: Our study reveals altered OS through TDH in ADPKD patients with varying eGFR levels. Significantly higher TTHIOL and NTHIOL levels were found in ADPKD patients with eGFR <60 ml/min/1.73 m2 compared to non-diabetic CKD patients with similar eGFR. Additionally, a significant positive correlation was identified between TTHIOL levels and eGFR values.
Minimally invasive surgery for adrenal masses in children: results of a bi-centric survey and Literature review.
Authors: Nascimben Francesca , Lachkar Amane , Becmeur Francois , Molinaro Francesco , Angotti Rossella , Andolfi Ciro , Geiss Stephan , Talon Isabelle
Published: January 2024

Background
Minimally invasive surgery for adrenal pathologies in children is still developing because of the low incidence of adrenal masses in pediatric population and the discrepancy between the size of the mass and the child’s one. In Literature there are no any guidelines about the use of laparoscopic andrenalectomy in children. The aim of this study is to evaluate the outcomes of minimally invasive surgery through a bi-center data analysis in order to propose a standardized protocol.
Materials and methods
Children who underwent minimally invasive adrenalectomy between 2000 and 2020 performed by two expert Pediatric surgeons at two European departments of Pediatric Surgery were included in this study. Data were collected and analyzed using X-square, Fisher tests, multiple regression model.
Results
34 patients (38 adrenal masse)s were included. Mean age was 52 months 3–176]. Median lesion diameter was 60 mm [40-125mm]. Histological examination revealed 24 neuroblastomas, 11 pheochromocytomas, 1 teratoma, 1 adrenal cyst and 1 Myelolipoma. Laterality was 52.6% left, 36.8% right and 10.5% bilateral. Surgical access was trans-peritoneal in all patients. Mean operative time was 108 min for unilateral lesions and 270 min for bilateral ones. Mean hospital stay was 4.4 days. No major intra operative complications were observed. 21.05% neuroblastomas were preventively approached with a laparoscopic access and were converted to open surgery. Median follow-up was 88 months [24–264]. 4 patients affected by neuroblastoma reported metastatic dissemination and 3 died.
Conclusions
Pediatric minimally invasive adrenalectomy was a safe and effective procedure, it allows surgeons to reduce the size of laparotomies starting the dissection of the masses and it has low rate of complication if we consider small masses. The only absolute contraindication is persistent IDRF for neuroblastomas. It should be considered the first-line treatment for selected adrenal masses in centers with good experience in laparoscopy.
Identification of Novel Inhibitors Against Glutamate Racemase of Klebsiella Pneumoniae Through Homology Modeling and Docking Studies
Authors: sharma Rajan Sharma rajan , Singh Rashmi Prabha Singh Dr. Rashmi Prabha
Published: January 2024

Klebsiella pneumoniae is a bacterium that gives rise to infections in humans as well as animals. It is found in the environment, including in soil and water, and can also be present in the human microbiome, particularly in the gastrointestinal tract. Klebsiella pneumoniae can lead to a range of illnesses, including pneumonia, infections of the urinary tract, and wound infections. It is more typically found in patients with compromised immune systems, such as those who are hospitalized, have underlying medical conditions, or are taking certain medications that suppress the immune system. Antibiotic-resistant strains of Klebsiella pneumoniae, such as those that are resistant to carbapenem antibiotics, have become a significant public health concern in recent years. These strains can be difficult to treat and can lead to severe infections and high mortality rates. MurI is an enzyme found in the bacterial species Klebsiella pneumoniae that is implicated in the production of peptidoglycan, a key component of the bacterial cell wall. Inhibiting the activity of MurI has been shown to be an effective technique to establish new antibiotics for the treatment of infections caused by K. pneumoniae. In this study, we used homology modeling and docking techniques to identify novel inhibitors of MurI. Homology modeling is a computational method that uses the structure of a similar protein to predict the structure of a target protein. Docking is a method that predicts how well a small molecule will fit into the active site of a protein. To identify potential inhibitors of MurI, we first built a homology model of the enzyme using the structure of a related protein as a template. We then used this model to perform docking studies with a large database of small molecules. The docking results allowed us to identify several compounds that had good binding affinity for the active site of MurI. We then performed further experiments to confirm the inhibitory activity of these compounds against MurI in vitro. Overall, our study demonstrates the utility of homology modeling and docking in the identification of novel inhibitors of MurI. These compounds may have the ability as new antibiotics for the treatment of Klebsiella pneumoniae infections.
Right patient to the right place: the impact of a 6-year regional trauma center-led prehospital trauma education program on patient outcomes
Authors: Choi Donghwan , Huh Yo , Kang Byung Hee , Kim Sora , Song Seoyoung , Jung Kyoungwon , Jung Hohyung
Published: January 2024

Background: In regional trauma systems, emergency medical service (EMS) providers render an important function by performing prehospital triage for severely injured patients and transporting them to regional trauma centers. Since 2016, a regional trauma center has been providing trauma surgeon-provided prehospital medical guidance for EMS providers through a trauma hotline to guide field triage, treatment, and transport. This study analyzedthe effects and clinical outcomes of a regional trauma center-led performance improvement program that followed closed-loop principles for EMS providers.
Methods: Data from the regional trauma center databases (2016–2021) were collected, and patients with trauma with an Injury Severity Score (ISS) >15 in the Gyeonggi province who were injured, regardless of whether they visited the trauma center directly or not, were included. After adjusting for severity and baseline demographics through propensity score matching, clinical outcomes were analyzed using logistic regression, and the results were expressed as relative risks with 95% confidence intervals (95% CIs).
Results: We included 3017 patients from the 6-year study period. Correct triage and undertriage were performed in 2528 and 489 patients, respectively. Prehospital medical directions and feedback were provided 432 times (32.1%) in 2016 and increased to 1505 times (96.8%) in 2021 (z=11.342, p<0.001). The undertriage rate decreased from 32.7% (n=55/168) to 6.3% (n=52/820) (z=−13.689, p<0.001), and the overall mortality decreased from 21.4% to 10% (z=−5.96, p<0.001). After propensity score matching, 484 correctly triaged and 484 undertriaged patients were identified for subgroup analyses. The in-hospital mortality of undertriaged and correctly triaged patients was 20.5% (n=99) and 12.6% (n=61), respectively. The relative risk (95% CI)for undertriaged over correctly-triaged patients regardingin-hospital mortality, length of intensive care unit (ICU) stay, and mechanical ventilation duration was 1.78 (1.26–2.52, p=0.001), 1.01 (1.00–1.02, p=0.052; mean ± standard deviation [SD] 12.2±20.2 vs. 10.0±13.5), and 1.01 (1.00–1.02, p=0.048, mean ± SD 7.2±17.9 vs. 5.2±10.9), respectively.
Conclusion: Undertriage was associated with increased in-hospital mortality, length of ICU stay, and mechanical ventilation duration. The closed-loop communication program for EMS providers improved the undertriage rate. Specifically, in the early stages of regional trauma-system development, the trauma center-led trauma hotline feedback and case-based education programs can be effective models to facilitate prehospital patient triage and centralization of patients with severe trauma to trauma centers.
Direct observation as data-collection method: Application in a commercial forensic interview
Authors: Graan Constant van , Roos Vera , Katjene Matthews
Published: January 2024

In applying direct observation to obtain data, few researchers in the field of commercial forensic interviewing (CFI) have to date focused on the design and implementation of direct observation and descriptive analysis. Direct observations are useful for collecting data, due to the sensitive nature of a commercial forensic interview (CFI) involving Commercial Forensic Practitioners (FPs) and interviewees. The aim of this study is twofold: First, develop an observational checklist. Second, to apply it in a CFI to document direct observation of the interactional style of FPs, interactions, and relational dynamics. A descriptive analysis checklist was developed, drawing on interview techniques previously identified as permissible in a South African legal context and developed by applying directed content analysis. Two observers, FPs trained as academic researchers, independently documented their observations in the CFI context. The observers’ responses yielded significant levels of consensus (≥ 80%), and the results demonstrated several relational qualities which successfully identify the FP’s interactional style; the relational dynamics at play during the interview (by observing the actions, impact, and reactions of the participants), and ineffective relational dynamics, which thwarted the goal of eliciting useful information. This study highlights the need for direct observation and contributes to the development of an effective observational checklist unique to the CFI context.
Development of a Canine Model for Chronic Heart Failure Treatment Using a Pacemaker-Compatible Vagus Nerve Stimulation Device
Authors: Hu Yuchi , Zhao Lulu , Dai Songyuan , Lu Yanzhou , Chen Liling , Lu Yanan , Li Hao , Huang Yimei , Li Chuanxin , Ma XUjuan , Zhao Ling , Hua Baotong
Published: January 2024

This present study aims to develop a vagus nerve stimulator compatible with a pacemaker to treat chronic heart failure(CHF) in a canine model, with the goal of alleviating side effects induced by Vagus Nerve Stimulation (VNS), such as bradycardia.Five dogs underwent rapid right ventricular pacing at a rate of 180–200 beats per minute for three months, and their clinical manifestations, electrocardiograms, echocardiography, and cardiac function were assessed. Subsequently, a canine model combining VNS with a pacemaker was established, and this combined system was continuously stimulated for one month. Electrocardiograms and program-controlled monitoring were observed after VNS implantation to evaluate its effectiveness.Each dog displayed clinical symptoms, encompassing reduced activity and wheezing. Echocardiography validated changes in both cardiac function and structure. Additionally, the electrocardiogram and programmable monitoring affirmed that treatment with VNS led to a reduction in heart rate. Subsequently, the pacemaker commenced operation post-monitoring, a development detectable by both the pacemaker and programmable monitoring. The establishment of a canine model integrating VNS with pacing confirmed the potential of a vagus nerve stimulator compatible with pacing to enhance the efficacy of standalone VNS.
Cefoxitin versus Cefepime for the Prevention of Perioperative Infection in Elderly Patients Undergoing Colorectal Cancer Surgery: A Retrospective Study
Authors: Liu Yangxi , Luo Yang , Xu Jing , Zhang Zaili , Shi Bisheng , Ni Xiaojun
Published: January 2024

Background
The optimal antibiotic prophylaxis in preventing perioperative infection in patients aged 70 who underwent colorectal cancer surgery of are unknown. We conducted a comparative analysis to evaluate the efficacy of cefoxitin and cefepime in preventing perioperative infections and assessed the inflammatory response to antibiotics during the perioperative period.
Methods
Patients over 70 years old and undergo surgery for colorectal cancer between January 2021 and June 2022 at the same ward of a tertiary teaching hospital in Shanghai, China were included. Demographic and clinical data were retrieved from hospital information system (HIS) to evaluate the body reaction of two antibiotic prophylaxis: patients in Group A received cefoxitin and in Group B accepted cefepime after surgery. Both antibiotics were intravenous 2000mg, two times daily, total 3 days. The effect of perioperative prevention was compared between two groups with any infection complications, hospital length of stay (HLOS), postoperative length of stay (POLS) and mortality during hospitalization.
Results
A total of 107 elderly patients (56 patients in Group A and 51 patients in Group B) with colorectal cancer were included. Two groups were similar in terms of tumor stage and other basic demographic. Patients received cefoxitin demonstrated lower infection complications (12.5% vs 13.7%, P = 0.851), among which surgical site infection (SSI) were most frequent complications in both groups (8.5% vs 9.8%, P = 0.877). However, patients with cefepime represented shorter HLOS (14.0 ± 4.7 days vs 13.9 ± 3.8 days, P = 0.912) and PLOS (9.4 ± 3.8 days vs 8.4 ± 2.1 days, P = 0.265). Additionally, the percentage of cluster of differentiation (CD) 4 + cell was significantly higher (29.2%±9.2 vs 46.5%±10.0, P = 0.001) and the percentage of CD8 + cell was statistical lower (26.1% [23.1, 34.4] vs 19.2% [15.5, 20.4], P = 0.004) in Group B compared to Group A at the third postoperative day. No death occurred in both groups.
Conclusion
Cefepime and cefoxitin both serve as useful prophylaxis to reduce infectious complications among elder patients underwent surgery for colorectal cancer. However, cefepime illustrated a more active inflammatory response and might enhance the body recovery in early post-operative rehabilitation.
Medication Adherence and Its Associated Factors among Kidney Transplant Patients in St. Paul’s Hospital Millennium Medical College
Authors: Derejie Meskerem Nimani , Dereje Erimas Nemani , Alemu Dirijit Mamo , Tesfay Yemane Gebremedhin , Banja Fufa Hunduma , Temie Negash Miniwye
Published: January 2024

Background: This study examines medication adherence among kidney transplant patients at St. Paul's Hospital in Addis Ababa, Ethiopia, focusing on the level of adherence and associated factors to immunosuppressant medicines.
Methods and Materials: A cross-sectional study was conducted on 270 patients from October 2021 to January 2022 using a structured questionnaire to be analyzed with SPSS version 26. The prevalence of medication adherence was computed, and a binary logistic regression was fitted to estimate the association. A 95% confidence interval and p-value <0.05 were used for statistical significance.
Results: The study found that 71.5% of kidney transplant patients were male, with a median age of 37 and a mean duration of 3.55 years. Medication adherence in post-kidney transplant patients was 81.9%. Being more than 5 years post-transplant and missing follow-up visits more than two times led to a 92.6% and 91.2% decrease in medication adherence respectively. Additionally, forgetfulness was associated with a 90.6% lower adherence level compared to drug unavailability and financial reasons.
Conclusion and recommendation: The study indicates that our patients exhibit higher medication adherence than WHO-measured levels, suggesting the need for healthcare providers to encourage this, especially for those above 5 years post-kidney transplant.
Effect of magma intrusion on pore structure and trace element migration of anthracite
Authors: Fu Xiang , Liu Xuan , Wu Qixuan , Xiao Bin , Fan Chaojun
Published: January 2024

Magma intrusion has an important influence on the physical and mechanical properties of coal and rock. In the area of magma intrusion, disasters such as gas outburst are prone to occur. Revealing its invasion law will be conducive to disaster management and energy development. For this purpose, changes in moisture, ash yield, volatile matter content, fixed carbon, mineral composition, major oxides, trace elements, and REE of coal under the thermal metamorphism of magma intrusion were analyzed. It is found that the moisture and volatile matter contents of the thermally affected coals in the mining face are generally lower than that of normal coals, while moisture and volatile matter contents are reduced towards to the magma intrusion contact. During magma intrusion, some minerals remain on the surface of the coal body, resulting in changes in the mineral composition of the coal body. The decrease in carbon atom net spacing, the increase in crystallite aggregation and ductility, and aromaticity in thermally affected coals have a positive impact on the improvement of coal metamorphism. Due to the influences of magmatic intrusion, the variation rules of major oxides in coal are different, and the closer to the magmatic intrusion zone, the easier the major oxides are to be depleted. However, magma intrusion will not lead to the loss of all major oxides in thermally affected coals, such as CaO and MnO contents are higher than unaffected coals. Most of the trace elements in the thermally affected coals of the No. 9 coal seam are depleted, while all of the elements Be, Cr, Ni, Tl, Pb, and U that are potentially hazardous to the environment are depleted. The contents of REE are low on the whole coalbasis, and the distribution pattern towards to magmatic intrusion shows a wide and gentle “ V ” curve with left high and right low, showing the characteristics of enrichment of LREE.
Non-detectable Patterns Hidden Withinsequences of Bits
Authors: Allen David , Luz Jose La , Salivia Guarionex , Hardwick Jonathan
Published: January 2024

In this paper we construct families of bit sequencesusing combinatorial methods. Each sequence is derived by connverting a collection of numbers encoding certain combinatorial numerics from objects exhibiting symmetry in various dimensions.Using the algorithms first described in [1] we show that the NIST testing suite described in publication 800-22 does not detect these symmetries hidden within these sequences.
Predictive effect of triglyceride-glucose index on No-Reflow Phenomenon in patients with type 2 diabetes mellitus and acute myocardial infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Ma Juan , Wang MoHan , Wu Peng , Ma Xueping , Chen Dapeng , Jia Shaobin , Yan Ning
Published: January 2024

Objective
Triglyceride glucose (TyG) index is considered as a new alternative marker of insulin resistance and a clinical predictor of type 2 diabetes mellitus (T2DM) combined with coronary artery disease. However, the prognostic value of TyG index on No-Reflow (NR) Phenomenon in T2DM patients with acute myocardial infarction (AMI) remains unclear.
Methods
In this retrospective study, 1683 patients with T2DM and AMI underwent primary percutaneous coronary intervention (PCI) were consecutively included between January 2014 and December 2019. The study population was divided into two groups as follows: Reflow (n = 1277) and No-reflow (n = 406) group. The TyG index was calculated as the ln [fasting triglycerides (mg/dL)×fasting plasma glucose (mg/ dL)/2].Multivariable logistic regression models and receiver-operating characteristic curve analysis were conducted to predict the possible risk of no-reflow. Net Reclassification Improvement (NRI) and Integrated Discrimination Improvement (IDI) were calculated to determine the ability of the TyG index to contribute to the baseline risk model.
Results
Multivariable logistic regression models revealed that the TyG index was positively associated with NR[OR,95%CI:5.03,(2.72,9.28),p༜0.001] in patients with T2DM and AMI. The area under the curve (AUC) of the TyG index predicting the occurrence of NR was [OR,95%CI:0.645 (95% CI 0.615–0.673; p < 0.001)], with the cut-off value of 8.98. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for NR [net reclassification improvement (NRI): 0.077(0.043to 0.111), integrated discrimination improvement (IDI): 0.070 (0.031to 0.108), all p < 0.001].
Conclusions
High TyG index was associated with an increased risk of no-reflow after PCI in AMI patients with T2DM. The TyG index may be a valid predictor of no-reflow phenomenon of patients with T2DM and AMI. Early recognition of no-reflow is critical to improve outcomes with AMI and T2DM patients.
Convective drying of chokeberry (Aronia melanocarpa Michx. Elliot) cv. ‘Viking’ and modeling
(Convective drying of chokeberry)
Authors: Unal Nafiye , Süslü Ahmet , Kulcu Recep , Dincer Cuneyt , İmirgi Eda Elif Yavuzlar , Ertekin Can
Published: January 2024

The effects of drying air temperatures (50, 60, 70 and 80oC) and velocities (0.5, 0.8, 1.2 m s− 1) used for the convective drying of chokeberry on fruit quality were quantified. In addition, the 11 different drying models were used to describe the drying kinetics of the chokeberry samples. The drying air temperature rise shortened the drying time from 2660 min at 50oC to 185 min at 80oC. Drying time was 220 min at the drying air velocity of 1.2 m s− 1. An increase in the temperature from 50 to 80oC and the air velocity from 0.5 m·s− 1 to 1.2 m·s− 1 enhanced fruit color quality index. All the drying treatments enriched the biochemical fruit content. 70oC and the air velocity between 0.5 m s− 1 and 1.2 m s− 1 achieved the highest antioxidant activity, total anthocyanin content and total phenolic content. Midilli et al. model exhibited the best fit to all experimental data (R2 ≥ 0.9978; χ2 ≤ 0.0003; RMSE ≤ 0.0161).
The Impact of Weight-loss Based Exercise Methods on Patients with Simple Obesity: A Comparative Study between Bicycle and Treadmill Training
Authors: Chen Peishun , Min Yu , Luo Yanjun , Zhang Wanrong
Published: January 2024

Objective It’s a comparative study between bicycle and treadmill groups to observe the effects of of weight-loss based exercise methods on patients with simple obesity, thus to provide a scientific basis for the healthy exercise methods to lose weight.
Methods 60 patients with simple obesity were randomly divided into two groups of 30: the bicycle group and the treadmill group. Both groups received high-intensity interval exercise training, power bicycle training andmoving treadmill training (MTT) were accepted respectively. Both groups received consecutive treatment for 12weeks, five times a week, and every single time lasted for 30minutes. Before and after treatment, the Body mass index (BMI), the knee’s articular cartilage volume was measured with magnetic resonance imaging (MRI)，the pain of knee was assessed with visual analogue scale (VAS). Before and after each training session, the local skin temperature of the knee was measured with an electronic thermometer.
Results After 12 weeks of treatment, the BMI was both decreased, the VAS and the local skin temperature of knee was increased significantly, the knee’s articular cartilage volume in the treadmill group was reduced significantly, while the above indicators in the bicycle group did not change significantly, and the difference between the two groups was statistically significant (p<0.001).
Conclusion Power bicycle training can avoid a decrease in the volume of knee joint cartilage, while MTT can easily lead to a decrease in the volume of knee joint cartilage, an increase in local skin temperature and pain of knee joint.
Structured-Unstructured Activity Behaviours on Young Children's Mental and Physical Health: A Compositional and Isotemporal Reallocation Analysis
Authors: Delong CHEN , Guanggao ZHAO , Jinmei FU , Sunli SHUN , Liqiang SU , Zihao HE , Ruiming CHEN , Tianle JIANG , Xuewen HU , Yunong Li , Fanchao Shen
Published: January 2024

Objective
This study aimed to investigate the effects of time reallocation between structured and unstructured activities on young children's mental and physical health.
Methods
324 children aged 3–6 years who volunteered to participate. Video observation combined with the System for Observing Play and Recreation in Communities (SOPARC) is used to classify structured and unstructured activity types. An accelerometer sensor ActiGraph GT3X-BT worn on the right iliac was used to measure activity intensity. The mental indicators of young children were collected using the Strengths and Difficulties Questionnaire (SDQ) and physical indicators such as Physical Shape and Physical Fitness were measured. The component data and isotemporal substitution analyses were also conducted with the help of R Studio (Version 4.2).
Results
Internalizing difficulties were significantly improved in young children using 10-minute structured moderate to vigorous physical activity (MVPA) or unstructured MVPA isotemporal substitution structured low-intensity physical activity (LPA), sedentary behaviour, with the effectiveness increasing as the substitution time lengthens. and the effect size increases with substitution time. physical shape was significantly improved in young children using 10-minute structured MVPA isotemporal substitution.
Conclusion
Increasing structured MVPA can improve young children's emotional symptoms and physical morphology, and increasing the proportion of MVPA in structured activities has higher health benefits.
A 78-year-old male with Rasagiline-Induced Pseudopheochromocytoma: The first Case Report from Syria
Authors: Almohamed Ahmad , Sleiay Mouhammed , Haydar Hasan , Almhamad Ebrahim , Hamsho Suaad , Kazkz Waddah
Published: January 2024

Background: Pseudopheochromocytoma is a clinical disorder characterized by severe paroxysmal vasoconstriction and normal or mildly to moderately elevated levels of catecholamines and metanephrine, without any evidence of a tumorous origin. Because the adrenergic system is activated, the patients have severe paroxysmal hypertension along with headache, palpitations, and diaphoresis. Rasagiline-induced pseudopheochromocytoma is very rare. Our case report is the first one worldwide manifesting with this medication.
Case presentation: The patient, a 78-year-old man with Parkinson's disease, started exhibiting symptoms of paroxysmal high blood pressure that did not decrease despite taking antihypertensive medications. An endocrine evaluation confirmed significantly elevated levels of urine dopamine and homovanillic acid, as well as plasma dopamine, with high levels of urine normetanephrine. Fludeoxyglucose scintigraphy ruled out the presence of a pheochromocytoma localized in the adrenals, migratory, or metastatic. A PET scan revealed no abnormalities. The Rasagiline treatment was stopped for eight days and was replaced with 200mg of amantadine every day. Two weeks after the discontinuation, we noticed a normalization of the elevated urinary and plasma dopamine levels as well as the increased urinary homovanil.
Conclusions: Pseudopheochromocytoma may be related to Rasagiline alone or in conjunction with other drugs that have a tendency to inhibit catecholamine or dopamine metabolism.
Sentiment Analysis of Video Danmakus Based on MIBE-RoBERTa-FF-BiLSTM
Authors: Zhao Jianbo , Liu Huailiang , Wang Yakai , Zhang Weili , Zhang Xiaojin , Li Bowei , Sun Tong , Qi Yanwei , Zhang Shanzhuang
Published: January 2024

Danmakus are user-generated comments that overlay on videos, enabling real-time interactions between viewers and video content. The emotional orientation of danmakus can reflect the attitudes and opinions of viewers on video segments, which can help video platforms optimize video content recommendation and evaluate users’ abnormal emotion levels. Aiming at the problems of low transferability of traditional sentiment analysis methods in the danmaku domain, low accuracy of danmaku text segmentation, poor consistency of sentiment annotation, and insufficient semantic feature extraction, this paper proposes a video danmaku sentiment analysis method based on MIBE-RoBERTa-FF-BiLSTM. This paper constructs a "Bilibili Must-Watch List and Top Video Danmaku Sentiment Dataset” by ourselves, covering 10,000 positive and negative sentiment danmaku texts of 18 themes. A new word recognition algorithm based on mutual information (MI) and branch entropy (BE) is used to discover 2,610 irregular network popular new words from trigrams to heptagrams in the dataset, forming a domain lexicon. The Maslow’s hierarchy of needs theory is applied to guide the consistent sentiment annotation. The domain lexicon is integrated into the feature fusion layer of the RoBERTa-FF-BiLSTM model to fully learn the semantic features of word information, character information, and context information of danmaku texts and perform sentiment classification. Comparative experiments on the dataset show that the model proposed in this paper has the best comprehensive performance among the mainstream models for video danmaku text sentiment classification, with an F1 value of 94.06%, and its accuracy and robustness are also better than other models. The limitations of this paper are that the construction of the domain lexicon still requires manual participation and review, the semantic information of danmaku video content and the positive case preference are ignored.
Severe toxic anterior segment syndrome with ocular hypotony: a case report and literature review
Authors: Zhu Yan , Zhou WeiWei , Zhu YuGuang
Published: January 2024

Background To report a rare case of severe toxic anterior segment syndrome with ocular hypotony after uneventful cataract surgery.
Case presentation Toxic anterior segment syndrome (TASS) is an infrequent complication of ocular surgery.Here,we reported a rare TASS case with ocularhypotony after uneventful cataract surgery.A 62-year-old male was presented to our clinic for blurred vision in the right eye.The patient was diagnosed with age-related cataract and the phacoemulsification and intraocular lens implantation was performed uneventfully in the right eye.On the first postoperative day,the diffuse cornea edema and dilated pupil were present in the right eye with a tentative diagnosis of TASS.The medication administration was inffective in the case.The patient developed corneal decompensation 1 year after cataract surgery.Given the resulting corneal edema, the patient underwent Penetrating keratoplasty (PKP),fibrin membrane removal and goniosynechialysis were performed simultaneously.Ocularhypotony developed unexpectedly 2 weeks after PKP and maintained steadily in the case.Ultrasound biomicroscopy (UBM)showed the ciliary body atrophy.Optical coherence tomography (OCT)showed chorioretinal folds caused by hypotony maculopathy after PKP.To the best of our knowledge, we first reported the TASS case with ocularhypotony.
Conclusions In the TASS case,the ocular hypotony was thought to be due to severe atrophy of ciliary body caused by uncertain toxic substance.
Determining The Association of Post-Stroke Epilepsy with The Location of Ischemic Stroke in Adult Patients
Authors: Khan Soban , Waqar Zaid , Iqbal Mansoor , Awan Malik Muhammad Adil , Khalid Bushra , Ali Syed Saad , Khalil Maryam , Saddiqa Amina , Solizay Asmat Ullah Khan
Published: January 2024

BACKGROUND AND OBJECTIVE: Seizures associated to stroke are recurrently encountered by a neurologist. Early post stroke seizures indicate an acute, and possibly recoverable brain damage while late seizures happen because of long-term alteration in brain after stroke. Medical probability models and bio and genetic markers should be combined in near future to aid the identification of progression of post stroke seizures and improve the recognition of post stroke epilepsy in individuals. A study was conducted to assess the role of ischemic stroke as a causative agent for epileptic seizures along the effect of stroke location on seizure severity.
METHODOLOGY: This study is a cross sectional study done over a period of 2 years at neurology department of Pakistan institute of Medical sciences. Study collected the relevant data from 71 patients admitted with ischemic stroke all of whom were monitored for any seizure episode.
RESULTS: Post stroke epilepsy was seen more commonly with ischemic strokes in middle cerebral artery territory. p value came as significant for Pearson Chi-Square and likelihood ratio while p value came as non-significant for linear-by-linear association.
CONCLUSION: As middle cerebral artery came out as hot stop for post stroke seizures, so any survivor of stroke caused due middle cerebral artery should undergo EEG (electroencephalography) which aids in the detection of precise patterns which are related to seizures.
Mood disorders in benign paroxysmal positional vertigo before and after treatment
Authors: Wang Huan , Hong Peiwei , Yan Weidong , Han Lin
Published: January 2024

Aim
Benign paroxysmal positional vertigo (BPPV) is associated with mood disorders. This study aimed to assess changes in anxiety, distress, and sleep in patients with BPPV before and after treatment.
Methods
Changes in mood disorders in patients with BPPV before and after treatment were evaluated with the dizziness handicap inventory (DHI), the Berg balance scale (BBS), the Hamilton Anxiety Rating Scale (HAMA), the Subjective Units of Distress Scale (anxiety level rating) (SUDS) and the Pittsburgh Sleep Quality Index (PSQI) questionnaires. Multiple-linear regression analysis was used to analyze factors influencing dizziness in patients with BPPV.
Results
After treatment, dizziness and mood disorders were alleviated (P < .001), and balance and sleep improved (P < .001). However, their symptoms were worse than the patients’ healthy family members who were the controls (P < .001). Multiple-linear regression analysis showed that BBS, HAMA, and SUDS influenced DHI in BPPV (r2 = 0.66, P < .001).
Conclusions
This study identified variables that influenced BPPV, demonstrating that anxiety, distress, and impaired balance acted as independent predictors for BPPV.
Qingjie Fuzheng Granules treat ulcerative colitis via regulating Th17/Treg cell balance
Authors: zhong hangyan , Liu Haiqin , Liu Jinhong , Yan Shuo , Zou Fenglin , Fan Youlong , Chen Xuzheng , Lin Jiumao
Published: January 2024

Objective:
To investigate the anti-inflammatory properties of Qingjie Fuzheng Granules (QFG)in vivo experiments using a DSS-induced ulcerative colitis (UC) model, and to elucidate the mechanism by which QFG alleviates UC by examining the Th17/Treg cell balance.
Methods: The DSS-induced UC mouse model was established, and the mice were administrated with QFG (1 g/kg) or saline by gavage. The general growth of the mice, including body weight, fecal occult blood, and disease activity index (DAI), was observed, and the length of the colon was recorded. HE staining was utilized to examine the pathological injury of the colon tissue. The expression levels of TGF-β, IFN-γ, IDO1, IL-1β, TNF-α, IL-6, IL-17, IL-21, IL-22, IL-25, IL-10 in serum were detected by ELISA or Bio-Plex. The relative mRNA expressions in spleen and colon tissues were detected by RT-qPCR. The protein expressions of RORγt, Foxp3 or IDO1 in spleen and colon were detected by Western Blot or Immunohistochemical.
Results:
QFG demonstrated potential for improving the overall pathological conditions of UC mice induced by DSS, as evidenced by its significant inhibition of colon length shortening and improvement of colon tissue pathology. Additionally, QFG exhibited the ability to decrease the expression of pro-inflammatory cytokines IL-1β, TNF-α, IFN-γ and IL-6, as well as IDO1 expression. Moreover, QFG significantly reduced the expression of Th17-related cytokines (IL-17, IL-21, IL-22, IL-25) and concurrently increased the expression of Treg-related cytokines (IL-10, TGF-β). The expression of transcription factor RORγt was observed to decrease while the transcription factor Foxp3 was observed to increase in colon and spleen.
Conclusion:
QFG has demonstrated the ability to suppress inflammation in mice with DSS-induced UC. This effect is achieved through the inhibition of Th17 cell differentiation, the promotion of Treg cell differentiation, and the maintenance of Th17/Treg cell balance. These actions are mediated by the regulation of transcription factors RORγt and Foxp3. This mechanism may contribute significantly to the observed inhibition of colon inflammation in mice treated with QFG.
Visual Evoked Potential And Contrast Sensitivity Tests In Anisometropic Amblyopia
Authors: Ashraf Eman , Nada Mona M. , Elhadidy Reem , ElSalmawy Dina , Shuaib Asmaa
Published: January 2024

Background
Amblyopia is a disorder of sight in which the brain fails to process inputs from one eye and over time favors the other eye. Refractive amblyopia is caued by anisometropia (difference of a certain degree of myopia, hypermetropia, or astigmatism), or by significant amount of equal refractive error in both eyes. Visual Evoked Potential/Response (VEP/VER) measures the electrical signal generated at the visual cortex in response to visual stimulation. Contrast sensitivity (CS) is the ability of the eye to detect small changes in illumination at targets that do not have clearly defined limits
Objectives
To compare between the amblyopic eye and the fellow eye regarding the VEP and CS in patients with anisometropic amblyopia.
Methods
This is a cross sectional study carried out on 78 patients with anisometropic amblyopia aging 4.5–12 years. All patients presented with monocular amblyopia. Pattern visual evoked potentials and contrast sensitivity tests were carried out for both eyes.
Results
the amblyopic eye showed an increases in P 100 latency and decrease in amplitude compared to the fellow eye. Also the contrast sensitivity test showed decreased values of the amblyopic eye compared to the fellow eye.
Conclusion
VEP and CS tests could be used to assess the prognosis of patients with anisometropic amblyopia.
Asymmetric response of cross-equatorial ocean heat transport to latitudinal thermal forcing in CESM
Authors: Liu Mingjia , Liu Fukai , Luo Yiyong , Lu Jian
Published: January 2024

The response of cross-equatorial ocean heat transport (OHT) to interhemispheric radiative imbalances is investigated using a set of fully coupled experiments with external radiative forcing imposed at different latitudinal bands at the top of the atmosphere. The modeling results reveal a first-order collaborative relationship between the ocean and the atmosphere, both working in tandem to facilitate the cross-equatorial heat transport to offset the imposed energy imbalance. Considerable asymmetry is also found between the responses to the radiative forcing placed at the same latitude, but in opposite hemispheres. This asymmetry is mainly attributed to the different changes in ocean circulation. When the radiative forcing is placed over the Southern Ocean, a buoyancy-driven clockwise cell is created that extends from the Southern Ocean into the tropics in both the Indo-Pacific and Atlantic basins, effectively transporting energy into the northern hemisphere. Conversely, when the radiative forcing is placed over the northern high latitudes, the Atlantic Meridional Overturning Circulation (AMOC) is weakened, leading to anomalous southward energy transport. In addition, our study reveals the reduced effectiveness of tropical forcing relative to higher latitude forcing in generating anomalous cross-equatorial OHT. This reduced effectiveness is due to the cancellation of the overturning cell-induced cross-equatorial OHT anomaly by the contribution of the horizontal gyre.
National Norms for the Obstetric nurses' and Midwives' health education competence, and its Influencing Factors: A Nationwide Cross-sectional Study
Authors: Zou Jingjing , Wu Jingling , Jiang Xiumin
Published: January 2024

Background
Strengthening obstetric nurses' and midwives' health education competence is the investment and guarantee for the population's future health. The purpose of study is to establish national norms for their health education competence, and explore possible influencing factors for providing an uniform criterion identifying levels and weaknesses.
Methods
An online questionnaire with a standard process was used to collect data. Three normative models were constructed, and multiple linear regression analysis analyzed possible influencing factors.
Results
The sample respondents (n = 3027) represented obstetric nurses and midwives nationally. Three health education competency normative norms (mean, percentile and demarcation norm) were constructed separately. Locations, hospital grade, department, marital status, training times and satisfaction with health education training influenced obstetrical nurses' and midwives' health education competence (P༜0.05).
Conclusion
This study constructed the first national standard for assessing obstetric nurses' and midwives' health education competence, providing a scientific reference to evaluate the degree of health education competence directly. These known factors could help clinical and policy managers designate practice improvement measures. In future research, Grade I hospitals should be studied with larger sample sizes, and indicators need to improve to reflect health education's effect better.