bluuebunny/crossref_metadata_2025 huggingface dataset:
Haplotype-resolved genomes provide insights into structural variation and gene content in Angus and Brahman cattle
Authors: Low Wai Yee , Tearle Rick , Liu Ruijie , Koren Sergey , Rhie Arang , Bickhart Derek M. , Rosen Benjamin D. , Kronenberg Zev N. , Kingan Sarah B. , Tseng Elizabeth , Thibaud-Nissen Françoise , Martin Fergal J. , Billis Konstantinos , Ghurye Jay , Hastie Alex R. , Lee Joyce , Pang Andy W. C. , Heaton Michael P. , Phillippy Adam M. , Hiendleder Stefan , Smith Timothy P. L. , Williams John L.
Published: April 2020

Inbred animals were historically chosen for genome analysis to circumvent assembly issues caused by haplotype variation but this resulted in a composite of the two genomes. Here we report a haplotype-aware scaffolding and polishing pipeline which was used to create haplotype-resolved, chromosome-level genome assemblies of Angus (taurine) and Brahman (indicine) cattle subspecies from contigs generated by the trio binning method. These assemblies reveal structural and copy number variants that differentiate the subspecies and that variant detection is sensitive to the specific reference genome chosen. Six genes with immune related functions have additional copies in the indicine compared with taurine lineage and an indicus-specific extra copy of fatty acid desaturase is under positive selection. The haplotyped genomes also enable transcripts to be phased to detect allele-specific expression. This work exemplifies the value of haplotype-resolved genomes to better explore evolutionary and functional variations.
Quantifying and understanding the triboelectric series of inorganic non-metallic materials
Authors: Zou Haiyang , Guo Litong , Xue Hao , Zhang Ying , Shen Xiaofang , Liu Xiaoting , Wang Peihong , He Xu , Dai Guozhang , Jiang Peng , Zheng Haiwu , Zhang Binbin , Xu Cheng , Wang Zhong Lin
Published: April 2020

Contact-electrification is a universal effect for all existing materials, but it still lacks a quantitative materials database to systematically understand its scientific mechanisms. Using an established measurement method, this study quantifies the triboelectric charge densities of nearly 30 inorganic nonmetallic materials. From the matrix of their triboelectric charge densities and band structures, it is found that the triboelectric output is strongly related to the work functions of the materials. Our study verifies that contact-electrification is an electronic quantum transition effect under ambient conditions. The basic driving force for contact-electrification is that electrons seek to fill the lowest available states once two materials are forced to reach atomically close distance so that electron transitions are possible through strongly overlapping electron wave functions. We hope that the quantified series could serve as a textbook standard and a fundamental database for scientific research, practical manufacturing, and engineering.
Inferring spatial and signaling relationships between cells from single cell transcriptomic data
Authors: Cang Zixuan , Nie Qing
Published: April 2020

Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however, crucial spatial information is often lost. We present SpaOTsc, a method relying on structured optimal transport to recover spatial properties of scRNA-seq data by utilizing spatial measurements of a relatively small number of genes. A spatial metric for individual cells in scRNA-seq data is first established based on a map connecting it with the spatial measurements. The cell–cell communications are then obtained by “optimally transporting” signal senders to target signal receivers in space. Using partial information decomposition, we next compute the intercellular gene–gene information flow to estimate the spatial regulations between genes across cells. Four datasets are employed for cross-validation of spatial gene expression prediction and comparison to known cell–cell communications. SpaOTsc has broader applications, both in integrating non-spatial single-cell measurements with spatial data, and directly in spatial single-cell transcriptomics data to reconstruct spatial cellular dynamics in tissues.
Isotopic evidence for initial coastal colonization and subsequent diversification in the human occupation of Wallacea
Authors: Roberts Patrick , Louys Julien , Zech Jana , Shipton Ceri , Kealy Shimona , Carro Sofia Samper , Hawkins Stuart , Boulanger Clara , Marzo Sara , Fiedler Bianca , Boivin Nicole , Mahirta  , Aplin Ken , OʼConnor Sue
Published: April 2020

The resource-poor, isolated islands of Wallacea have been considered a major adaptive obstacle for hominins expanding into Australasia. Archaeological evidence has hinted that coastal adaptations in Homo sapiens enabled rapid island dispersal and settlement; however, there has been no means to directly test this proposition. Here, we apply stable carbon and oxygen isotope analysis to human and faunal tooth enamel from six Late Pleistocene to Holocene archaeological sites across Wallacea. The results demonstrate that the earliest human forager found in the region c. 42,000 years ago made significant use of coastal resources prior to subsequent niche diversification shown for later individuals. We argue that our data provides clear insights into the huge adaptive flexibility of our species, including its ability to specialize in the use of varied environments, particularly in comparison to other hominin species known from Island Southeast Asia.
Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML
Authors: Hart Steven N. , Polley Eric C. , Shimelis Hermella , Yadav Siddhartha , Couch Fergus J.
Published: April 2020

In silico predictions of missense variants is an important consideration when interpreting variants of uncertain significance (VUS) in the BRCA1 and BRCA2 genes. We trained and evaluated hundreds of machine learning algorithms based on results from validated functional assays to better predict missense variants in these genes as damaging or neutral. This new optimal “BRCA-ML” model yielded a substantially more accurate method than current algorithms for interpreting the functional impact of variants in these genes, making BRCA-ML a valuable addition to data sources for VUS classification.
An annual time series of weekly size-resolved aerosol properties in the megacity of Metro Manila, Philippines
Authors: Stahl Connor , Cruz Melliza Templonuevo , Bañaga Paola Angela , Betito Grace , Braun Rachel A. , Aghdam Mojtaba Azadi , Cambaliza Maria Obiminda , Lorenzo Genevieve Rose , MacDonald Alexander B. , Pabroa Preciosa Corazon , Yee John Robin , Simpas James Bernard , Sorooshian Armin
Published: April 2020

Size-resolved aerosol samples were collected in Metro Manila between July 2018 and October 2019. Two Micro-Orifice Uniform Deposit Impactors (MOUDI) were deployed at Manila Observatory in Quezon City, Metro Manila with samples collected on a weekly basis for water-soluble speciation and mass quantification. Additional sets were collected for gravimetric and black carbon analysis, including during special events such as holidays. The unique aspect of the presented data is a year-long record with weekly frequency of size-resolved aerosol composition in a highly populated megacity where there is a lack of measurements. The data are suitable for research to understand the sources, evolution, and fate of atmospheric aerosols, as well as studies focusing on phenomena such as aerosol-cloud-precipitation-meteorology interactions, regional climate, boundary layer processes, and health effects. The dataset can be used to initialize, validate, and/or improve models and remote sensing algorithms.
RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways
Authors: Formoso Karina , Susperreguy Sebastian , Freichel Marc , Birnbaumer Lutz
Published: April 2020

The seven-member transient receptor potential canonical genes (TRPC1-7) encode cation channels linked to several human diseases. There is little understanding of the participation of each TRPC in each pathology, considering functional redundancy. Also, most of the inhibitors available are not specific. Thus, we developed mice that lack all of the TRPCs and performed a transcriptome analysis in eight tissues. The aim of this research was to address the impact of the absence of all TRPC channels on gene expression. We obtained a total of 4305 differentially expressed genes (DEGs) in at least one tissue where spleen showed the highest number of DEGs (1371). Just 21 genes were modified in all the tissues. Performing a pathway enrichment analysis, we found that many important signaling pathways were modified in more than one tissue, including PI3K (phosphatidylinositol 3-kinase/protein kinase-B) signaling pathway, cytokine-cytokine receptor interaction, extracellular matrix (ECM)-receptor interaction and circadian rhythms. We describe for the first time the changes at the transcriptome level due to the lack of all TRPC proteins in a mouse model and provide a starting point to understand the function of TRPC channels and their possible roles in pathologies.
Unraveling the genetic origin of ‘Glera’, ‘Ribolla Gialla’ and other autochthonous grapevine varieties from Friuli Venezia Giulia (northeastern Italy)
Authors: Crespan Manna , Migliaro Daniele , Larger Simone , Pindo Massimo , Petrussi Carlo , Stocco Marco , Rusjan Denis , Sivilotti Paolo , Velasco Riccardo , Maul Erika
Published: April 2020

‘Glera’ and ‘Ribolla Gialla’ are the most economically relevant local grapevine cultivars of Friuli Venezia Giulia region (north-eastern Italy). ‘Glera’ is used to produce the world-renowned Prosecco wine. ‘Ribolla Gialla’ cultivation is constantly increasing due to the strong demand for sparkling wine and is the most important variety in Brda (Slovenia). Knowledge of local varieties history in terms of migration and pedigree relationships has scientific and marketing appeal. Following prospections, genotyping and ampelographic characterization of minor germplasm in Friuli Venezia Giulia, a further research was developed to understand the parentage relationships among the grapevine varieties grown in this region. An integrated strategy was followed combining the analysis of nuclear and chloroplast microsatellites with theVitis18k SNP chip. Two main recurrent parents were found, which can be regarded as “founders”: ‘Vulpea’, an Austrian variety parent-offspring related with at least ten Friuli Venezia Giulia cultivars, among them ‘Glera’, and ‘Refosco Nostrano’, first degree related with other six Friuli Venezia Giulia varieties. ‘Ribolla Gialla’ was shown to be another member of the impressively long list of offspring derived from the prolific ‘Heunisch Weiss’. Combining molecular markers and historical references was a high-performance strategy for retracing and adjusting the history of cultivars.
Spatial Beam Self-Cleaning in Second-Harmonic Generation
Authors: Krupa K. , Fona R. , Tonello A. , Labruyère A. , Shalaby B. M. , Wabnitz S. , Baronio F. , Aceves A. B. , Millot G. , Couderc V.
Published: April 2020

We experimentally demonstrate the spatial self-cleaning of a highly multimode optical beam, in the process of second-harmonic generation in a quadratic nonlinear potassium titanyl phosphate crystal. As the beam energy grows larger, the output beam from the crystal evolves from a highly speckled intensity pattern into a single, bell-shaped spot, sitting on a low energy background. We demonstrate that quadratic beam cleanup is accompanied by significant self-focusing of the fundamental beam, for both positive and negative signs of the linear phase mismatch close to the phase-matching condition.
Ag- or Cu-modified geopolymer filters for water treatment manufactured by 3D printing, direct foaming, or granulation
Authors: Luukkonen Tero , Yliniemi Juho , Sreenivasan Harisankar , Ohenoja Katja , Finnilä Mikko , Franchin Giorgia , Colombo Paolo
Published: April 2020

In this work, we compared the main characteristics of highly porous geopolymer components for water treatment applications manufactured by 3D printing, direct foaming, or granulation. Furthermore, different approaches to impregnate the materials with Ag or Cu were evaluated to obtain filters with disinfecting or catalytic properties. The results revealed that all of the investigated manufacturing methods enabled the fabrication of components that possessed mesoporosity, suitable mechanical strength, and water permeability, even though their morphologies were completely different. Total porosity and compressive strength values were 28 vol% and 16 MPa for 3D-printed, 70–79 vol% and 1 MPa for direct-foamed, and 27 vol% and 10 MPa for granule samples. Both the filter preparation and the metal impregnation method affected the amount, oxidation state, and stability of Ag and Cu in the filters. However, it was possible to prepare filters with low metal leaching between a pH of 3–7, so that the released Ag and Cu concentrations were within drinking water standards.
Comparison of surgical outcomes of slanted procedure for exotropia with convergence insufficiency according to their response to preoperative monocular occlusion
Authors: Chun Bo Young , Oh Jun Ho , Choi Hyung Jun
Published: April 2020

The aim of this prospective study was to compare surgical outcomes of slanted bilateral lateral rectus (LR) recession for intermittent exotropia (IXT) with convergence insufficiency (CI) according to their response to preoperative monocular occlusion. This prospective study included 55 children who underwent slanted bilateral LR recession for IXT with CI. Patients were divided into two groups according to their response to preoperative monocular occlusion for 2 hours. The True CI group was defined as having near-distance differences of ≥10 PD before and after occlusion; the Masked CI group as having near-distance differences of <10 PD and ≥10 PD prior to and after occlusion. Slanted procedure reduced distance and near exodeviations from 32.1 PD and 43.0 PD to 3.5 PD and 4.4 PD, and collapsed near-distance differences from 10.9 PD to 1.0 PD at 3 years postoperatively. Cumulative probabilities of surgical success were 76%, and the mean recurrence was 50 months at 3 years postoperatively; the True CI and Masked CI groups showed cumulative success rates of 89% and 55%, respectively (p = 0.0052). Patients in the True CI group demonstrated surgical outcomes superior to those demonstrated by patients in the Masked CI group after slanted bilateral LR recession.
Diverse HCV Strains And HIV URFS Identified Amongst People Who Inject Drugs In India
Authors: Rodgers Mary A. , Gomathi Selvamurthi , Vallari Ana , Saravanan Shanmugam , Lucas Gregory M. , Mehta Shruti , Solomon Sunil S. , Cloherty Gavin A.
Published: April 2020

Although the prevalences of HIV and HCV are significantly higher amongst PWID in India compared to the general population, the strains circulating within this group have not been well-characterized. Through subgenomic sequencing of viruses present in residual plasma from an HIV/HCV prevalence study conducted amongst PWID across five cities in India in 2016–2017, a total of N = 498 HCV and N = 755 HIV strains were classified from N = 975 study participants. Considerable HCV diversity was identified, with different strains predominating in each region of the country. Overall, the most common strain was genotype 3a (39.0%), with genotypes 1a (26.9%), 1b (3.0%), 1c (0.2%), 3b (20.7%), 3i (2.0%), 4a (0.2%), 4d (1.0%), 6 (1.8%), 6n (4.8%), 6 v (0.2%) and one unclassifiable recombinant specimen (0.2%) also identified. The majority of the HIV specimens were subtype C (96.7%), although subtype A (0.4%), CRF01_AE (0.4%) and unique recombinant forms (URFs, 2.5%) were also detected. Notably, the geographical restriction of HIV subtype A and CRF01_AE, and HCV genotypes 4 and 6 to specific sites suggests distinct novel introductions of HIV and HCV into PWID populations, potentially via drug trafficking routes from neighboring countries where these strains are common.
Hyperreflective Walls in Foveal Cystoid Spaces as a Biomarker of Diabetic Macular Edema Refractory to Anti-VEGF Treatment
Authors: Terada Noriko , Murakami Tomoaki , Uji Akihito , Dodo Yoko , Mori Yuki , Tsujikawa Akitaka
Published: April 2020

Diabetic macular edema (DME) refractory to anti-VEGF drugs is a socioeconomic burden. In this retrospective study, we investigated the relationship between DME remission and hyperreflective walls in foveal cystoid spaces, a novel finding on spectral domain optical coherence tomography (SD-OCT) images in DME. In a cross-sectional study, we assessed the relationship between hyperreflective walls in foveal cystoid spaces and other OCT findings in 110 eyes of 110 DME patients. Hyperreflective walls were delineated in 27 of 171 foveal cystoid spaces. Eyes with hyperreflective walls in foveal cystoid spaces had poorer visual acuity and more severe photoreceptor disruption than did those without such findings (P = 0.008 and P < 0.001, respectively). In the other longitudinal study, we evaluated the relationship between this finding and the remission in 54 eyes of 51 DME patients treated with as-needed ranibizumab injections for 24 months. Foveal cystoid spaces with hyperreflective walls were often persistent, and the cumulative rates of DME remission among eyes with and without the hyperreflective walls were 7.7% (1 eye) and 48.8% (20 eyes) at 18 months (hazard ratio, 0.092; P = 0.025). We characterized hyperreflective walls in foveal cystoid spaces and designated them as a predictor of no DME remission under ranibizumab injections.
Dendritic silver self-assembly in molten-carbonate membranes for efficient carbon dioxide capture
Authors: McNeil Liam A. , Mutch Greg A. , Iacoviello Francesco , Bailey Josh J. , Triantafyllou Georgios , Neagu Dragos , Miller Thomas S. , Papaioannou Evangelos I. , Hu Wenting , Brett Dan J. L. , Shearing Paul R. , Metcalfe Ian S.
Published: April 2020

Self-assembling Ag dendritic networks provide ultrahigh CO2 permeability, whilst reducing membrane-volume-normalised Ag demand by an order of magnitude.
Intrinsically self-healable, stretchable thermoelectric materials with a large ionic Seebeck effect
Authors: Akbar Zico Alaia , Jeon Ju-Won , Jang Sung-Yeon
Published: April 2020

We report intrinsically self-healable and stretchable ionic thermoelectric materials, which exhibits excellent ionic figure-of-merit (1.04), with remarkable stretchability (~750%) and autonomous self-healability.
High Curie temperature and carrier mobility of novel Fe, Co and Ni carbide MXenes
Authors: Hu Y. , Liu X. Y. , Shen Z. H. , Luo Z. F. , Chen Z. G. , Fan X. L.
Published: April 2020

MXenes have intrinsic and robust ferromagnetism well above room temperature as well as high and anisotropic carrier mobility.
Exploring intermolecular contacts in multi-substituted benzaldehyde derivatives: X-ray, Hirshfeld surface and lattice energy analyses
Authors: Hulushe Siya T. , Manyeruke Meloddy H. , Louzada Marcel , Rigin Sergei , Hosten Eric C. , Watkins Gareth M.
Published: April 2020

We report here crystal packing, and Hirshfeld surface and Lattice energy analyses of six new multi-substituted benzaldehyde derivatives for the first time.
Controllable growth of three-dimensional CdS nanoparticles on TiO2nanotubes to enhance photocatalytic activity
Authors: Liu Guo-Min , Jia Wen-Yuan , Jiang Qiu-Shi , Cheng Zhi-Qiang
Published: April 2020

Exploiting photocatalysts with characteristics of low cost, high reactivity and good circularity is a great significance for environmental remediation and energy conversion.
Strain induced rich planar defects in heterogeneous WS2/WO2 enable efficient nitrogen fixation at low overpotential
Authors: Ling Ying , Kazim Farhad M. D. , Ma Shuangxiu , Zhang Quan , Qu Konggang , Wang Yangang , Xiao Shenglin , Cai Weiwei , Yang Zehui
Published: April 2020

Incorporation of WO2 to WS2 nanosheets can efficiently suppress the competitive hydrogen evolution reaction (HER) due to the reduction of edge defects and create new planar defects at heterointerfaces for nitrogen reduction reaction (NRR).
Covalent and ionic bonding in bi- and tricyclic Group 15 amides: equidistant P–I and As–I bonds and fluxional cations
Authors: Musongong Joseph T. , Otang Mathew E. , Mash Brandon L. , Zeller Matthias , Stahl Lothar
Published: April 2020

Bonding variations from completely covalent, via polar covalent to completely ionic in bi- and tricyclic Group 15 amides.
Protective effects ofBifidobacterium adolescentison collagen-induced arthritis in rats depend on timing of administration
Authors: Fan Zhexin , Yang Bo , Ross R. Paul , Stanton Catherine , Shi Guoxun , Zhao Jianxin , Zhang Hao , Chen Wei
Published: April 2020

Early probiotics adminitration is a key timing to alleviate inflammation in rats with arthritis.
Bioavailability of red wine and grape seed proanthocyanidins in rats
Authors: Pereira-Caro Gema , Gaillet Sylvie , Ordóñez José Luis , Mena Pedro , Bresciani Letizia , Bindon Keren A. , Del Rio Daniele , Rouanet Jean-Max , Moreno-Rojas José Manuel , Crozier Alan
Published: April 2020

This study explored plasma levels and urinary and fecal excretion of metabolites and microbial-derived catabolites over a 24 h period following the ingestion of red wine (RWP) or grape seed (GSP) proanthocyanidin-rich extracts by rats.
Water-dispersible few-layer graphene flakes for selective and rapid ion mercury (Hg2+)-rejecting membranes
Authors: Najafi Leyla , Oropesa-Nuñez Reinier , Martín-García Beatriz , Drago Filippo , Prato Mirko , Pellegrini Vittorio , Bonaccorso Francesco , Bellani Sebastiano
Published: April 2020

Rhodamine 6g-functionalized graphene-based membrane is designed to perform rapid and highly selective Hg2+ rejection from water.
Efficient sub-15 nm cubic-phase core/shell upconversion nanoparticles as reporters for ensemble and single particle studies
Authors: Tan Meiling , Monks Melissa-Jane , Huang Dingxin , Meng Yongjun , Chen Xuewen , Zhou Ying , Lim Shuang-Fang , Würth Christian , Resch-Genger Ute , Chen Guanying
Published: April 2020

A set of sub-15 nm ytterbium-enriched α-NaYbF4:Er3+@CaF2core/shell upconversion nanoparticles have been developed for both ensemble- and single particle-level imaging studies, presenting a high quantum yield of 0.77% at a low saturation power density of 110 W cm−2.
Conductive conduit small gap tubulization for peripheral nerve repair
Authors: Fang Xingxing , Deng Jiuxu , Zhang Wei , Guo Haichang , Yu Fei , Rao Feng , Li Qicheng , Zhang Peixun , Bai Shulin , Jiang Baoguo
Published: April 2020

rGO-based conductive nerve conduit as a scaffold to bridge peripheral nerve transected injury and 2 mm gap provides a suitable microenvironment for axons selective regeneration.
Geometric landscapes for material discovery within energy–structure–function maps
Authors: Moosavi Seyed Mohamad , Xu Henglu , Chen Linjiang , Cooper Andrew I. , Smit Berend
Published: April 2020

We introduce a representation for the geometric features of the pores of porous molecular crystals. This representation provides a good basis for supervised (predict adsorption properties) and unsupervised (polymorph classification) tasks.
Impact of substituents on molecular properties and catalytic activities of trinuclear Ru macrocycles in water oxidation
Authors: Meza-Chincha Ana-Lucia , Lindner Joachim O. , Schindler Dorothee , Schmidt David , Krause Ana-Maria , Röhr Merle I. S. , Mitrić Roland , Würthner Frank
Published: April 2020

Conformational changes induced by ligand substituents in macrocyclic Ru complexes strongly affect their chemical and photocatalytic efficiencies in water oxidation.
Cascade polymerizations: recent developments in the formation of polymer repeat units by cascade reactions
Authors: Peterson Gregory I. , Choi Tae-Lim
Published: April 2020

Cascade polymerizations provide new routes to unique polymer structures. In this perspective, we summarize their performance, monomer scope, and mechanisms.
Water-induced formation of an alkali-ion dimer in cryptomelane nanorods
Authors: Cheng Shaobo , Sharma Vidushi , Poyraz Altug S. , Wu Lijun , Li Xing , Marschilok Amy C. , Takeuchi Esther S. , Takeuchi Kenneth J. , Fernández-Serra Marivi , Zhu Yimei
Published: April 2020

Water displaces potassium ions and initiates the formation of a homonuclear dimer ion (K2+) in the tunnels of hollandite.
Insight into the unwrapping of the dinucleosome
Authors: Khodabandeh Fatemeh , Fatemi Hashem , Mohammad-Rafiee Farshid
Published: April 2020

The energy landscape and configurations of dinucleosome in different unwrapped states are studied. The dynamical Monte-Carlo simulation demonstrates dynamical features such as the unwrapping force for partial/full wrapping processes.
Novel one-step electrophoretic deposition of the membrane-electrode assembly for flexible-battery applications
Authors: Cohen Elazar , Lifshitz Moran , Gladkikh Alexander , Kamir Yossi , Ben-Barak Ido , Golodnitsky Diana
Published: April 2020

Simple and low-cost manufacturing of energy storage devices by a novel single-step simultaneous electrophoretic deposition of oppositely charged cathode and anode particles on both sides of microporous membrane.
Thermally evaporated methylammonium-free perovskite solar cells
Authors: Ji Ran , Zhang Zongbao , Cho Changsoon , An Qingzhi , Paulus Fabian , Kroll Martin , Löffler Markus , Nehm Frederik , Rellinghaus Bernd , Leo Karl , Vaynzof Yana
Published: April 2020

Efficient thermally evaporated MA-free perovskite solar cells are developed by optimising their stoichiometry and annealing procedures.
Unconventional out-of-plane domain inversion via in-plane ionic migration in a van der Waals ferroelectric
Authors: Xu Dong-Dong , Ma Ru-Ru , Zhao Yi-Feng , Guan Zhao , Zhong Qi-Lan , Huang Rong , Xiang Ping-Hua , Zhong Ni , Duan Chun-Gang
Published: April 2020

Unconventional out-of-plane domain inversion induced by an in-plane electric field has been observed and clarified experimentally.
IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway
Authors: Pei Bing , Chen Keyan , Zhou Shenglai , Min Dongyu , Xiao Weiguo
Published: April 2020

Objective: To observe the restraining effect of IL-38 on inflammatory response in collagen-induced arthritis rats (CIA), and to explore the regulatory mechanism of SIRT1/HIF-1α signaling pathway.

Methods: 40 SD rats were randomly divided into Control group, CIA group, CLL group and CLH group, with 10 rats in each group; CIA rat model was established. The effects of IL-38 on arthritis index, inflammatory response, osteogenic factor and angiogenic factor were observed by methods including HE staining, ELISA, immunohistochemical and immunofluorescence. Human synoviocytes were cultured in vitro, and SIRT1 inhibitors were added to detect the expression for relating factors of SIRT1/HIF-1α signaling pathway by Western blot.

Results: IL-38 could alleviate CIA joint damage and restrain inflammatory response, could up-regulate the expression of OPG in CIA rats and could down-regulate the expression of RANKL and RANK. IL-38 could restrain the expression of VEGF, VEGFR1, VEGFR2 and HIF. Moreover, we found that IL-38 could up-regulate the SIRT1 expression and down-regulate the HIF-1α, TLR4 and NF-KB p65 expression in CLL and CLH groups. From the treatment of synoviocytes to simulate the CIA model and the treatment of SIRT1 inhibitors, we demonstrated that the inhibitory effect of IL-38 on inflammatory factors and regulation of SIRT1/HIF-1α signaling pathway-related proteins were inhibited.

Conclusion: IL-38 can restrain the inflammatory response of CIA rats, can promote the expression of osteogenic factors, can inhibit neovascularization, and can alleviate joint damage in rats. The mechanism may be related to the regulation of SIRT1/HIF-1α signaling pathway.
WITHDRAWN: MiR-760 inhibits the progression of non-small cell lung cancer through blocking
ROS1
/Ras/Raf/MEK/ERK pathway
Authors: Wang Wei , He Bin
Published: April 2020

The Accepted Manuscript version of this article (published on 29 April 2020) was withdrawn on 8 June 2020 due to concerns over authorship and data validity.
The Massive and Distant Clusters of WISE Survey
Authors: Di Mascolo Luca , Mroczkowski Tony , Churazov Eugene , Moravec Emily , Brodwin Mark , Gonzalez Anthony , Decker Bandon B. , Eisenhardt Peter R. M. , Stanford Spencer A. , Stern Daniel , Sunyaev Rashid , Wylezalek Dominika
Published: April 2020

Context. The Massive and Distant Clusters of WISE Survey (MaDCoWS) provides a catalog of high-redshift (0.7 ≲ z ≲ 1.5) infrared-selected galaxy clusters. However, the verification of the ionized intracluster medium, indicative of a collapsed and nearly virialized system, is made challenging by the high redshifts of the sample members.

Aims. The main goal of this work is to test the capabilities of the Atacama Compact Array (ACA; also known as the Morita Array) Band 3 observations, centered at about 97.5 GHz, to provide robust validation of cluster detections via the thermal Sunyaev–Zeldovich (SZ) effect.

Methods. Using a pilot sample that comprises ten MaDCoWS galaxy clusters, accessible to ACA and representative of the median sample richness, we infer the masses of the selected galaxy clusters and respective detection significance by means of a Bayesian analysis of the interferometric data.

Results. Our test of the Verification with the ACA – Localization and Cluster Analysis (VACA LoCA) program demonstrates that the ACA can robustly confirm the presence of the virialized intracluster medium in galaxy clusters previously identified in full-sky surveys. In particular, we obtain a significant detection of the SZ effect for seven out of the ten VACA LoCA clusters. We note that this result is independent of the assumed pressure profile. However, the limited angular dynamic range of the ACA in Band 3 alone, short observational integration times, and possible contamination from unresolved sources limit the detailed characterization of the cluster properties and the inference of the cluster masses within scales appropriate for the robust calibration of mass–richness scaling relations.
Sharp stability for the Riesz potential
Authors: Fusco Nicola , Pratelli Aldo
Published: April 2020

In this paper we show the stability of the ball as maximizer of the Riesz potential among sets of given volume. The stability is proved with sharp exponent 1∕2, and is valid for any dimension N ≥ 2 and any power 1 < α < N.
Geometrically intrinsic modeling of shallow water flows
Authors: Bachini Elena , Putti Mario
Published: April 2020

Shallow water models of geophysical flows must be adapted to geometric characteristics in the presence of a general bottom topography with non-negligible slopes and curvatures, such as a mountain landscape. In this paper we derive an intrinsic shallow water model from the Navier–Stokes equations defined on a local reference frame anchored on the bottom surface. The equations resulting are characterized by non-autonomous flux functions and source terms embodying only the geometric information. We show that the proposed model is rotational invariant, admits a conserved energy, is well-balanced, and it is formally a second order approximation of the Navier–Stokes equations with respect to a geometry-based order parameter. We then derive a numerical discretization by means of a first order upwind Godunov finite volume scheme intrinsically defined on the bottom surface. We study convergence properties of the resulting scheme both theoretically and numerically. Simulations on several synthetic test cases are used to validate the theoretical results as well as more experimental properties of the solver. The results show the importance of taking into full consideration the bottom geometry even for relatively mild and slowly varying curvatures.
Gustav Mie: the man, the theory
Authors: Stout Brian , Bonod Nicolas
Published: April 2020

Gustav Mie was a German scientist who published a rigorous electromagnetic scattering theory by a spherically shaped particle in 1908, but which only began to attract attention some fifty years later. How then did Gustav Mie, who was initially attracted to science by his interest in mathematics and mineralogy, publish a ‘hidden gem’ that now shines so brightly over physics?
Terahertz spectroscopy using quantum-cascade lasers
Authors: Hübers Heinz-Wilhelm , Richter Heiko , Wienold Martin , Lü Xiang , Schrottke Lutz , Grahn Holger T.
Published: April 2020

Terahertz (THz) quantum-cascade lasers (QCLs) provide powerful, narrow-band, and frequencytunable radiation, which makes them ideal sources for high-resolution molecular spectroscopy. A first application of a THz QCL has been as local oscillator in a heterodyne spectrometer for astronomy on board a Boeing 747. For laboratory spectroscopy, QCLs close the so-called THz gap and enable new research topics.
A new European cancer risk assessment tool for application after nuclear accidents
Authors: Walsh L. , Ulanowski A. , Kaiser J.C. , Woda C. , Raskob W.
Published: April 2020

The development and application of new European software for cancer risk assessment after radiation exposure from a nuclear accident is described here. This software computes lifetime risks for several types of cancer and is intended to provide information for consideration by decision makers in the urgent and transition phases of nuclear emergencies. Such information on radiation related cancer risks can be useful to consider in the identification of protective measures (e.g., sheltering, evacuation, allocation of individuals to screening programmes and advice to take thyroid protection medication) in a differential way (i.e., for particularly susceptible sub-groups of a population). A description and application of the software for converting dose limits applicable after nuclear accidents into corresponding cancer risks, based on German population data, has already been published. Therefore, only a brief description of the main features of the software and some new illustrative results based on Swiss population data are given here, with some additional information on the input and output specification of the software.
Decisions for Stock Investment among University Students
Authors: Pertiwi Dewi , Ronni Basana Sautma , Grace Yasinta Marcella
Published: April 2020

This study aimed to investigate the effect of economic value added and profitability on created shareholders value Fernandez model and market value added model in manufacturing companies listed on the Indonesia Stock Exchange period year 2013 to 2018. The samples are fifty Manufacturing companies enterprises listed on the IDX period year 2013 to 2018. Methods of data analysis was performed using panel data regression with pooled OLS model. The results of this analysis showed profitability have a significant effect on created shareholders value Fernandez model and market value added model in manufacturing companies listed on the IDX period 2013 to 2018.
The Effect of Brand Ambassador, Brand Image, and Brand Awareness on Purchase Decision of Pantene Shampoo in Surabaya, Indonesia
Authors: Sari Dewi Luh Gede Permata , Edyanto Natasya , Siagian Hotlan
Published: April 2020

Cosmetics industry growth development in Indonesia was improving up to 20 % or four times compared to national economy growth. The cosmetics industry was one of the leading sectors. Lots of cosmetic industry was using the public figure as their advertisement tool to affect the consumers. The selection of public figures as brand ambassadors to build brand image and brand awareness had the goal of affecting people in their purchase decision. The object in this research was Pantene shampoo. Data collection in the research was done with distributing surveys. The sample in this research was 100 respondents, using a purposing sampling method and using partial least square as a statistic processing tool. Based on the result and analysis, the brand ambassador that Pantene shampoo was using had a significant effect on brand awareness. Brand ambassador Pantene had a significant effect on brand image, brand awareness. Brand ambassador and brand image also had a significant effect on the consumer's purchase decision. This research was meant to contribute to selecting public figures as brand ambassador that was used by the company in producing Pantene shampoo had been suitable with the Surabaya’s people desire.
The Analysis Factor of Medical Tourism in Singapore
Authors: Lianto Martin , Suprapto Widjojo , Mel Maizirwan
Published: April 2020

Indonesian citizens have spent the USD 11.5 × 109 for medical treatment services abroad. Singapore is one of the favorite countries in medical tourism for Indonesian people. This research aims at analyzing the attraction factors of medical tourism in Singapore. There are 100 respondents visited Singapore to do medical tourism. The retrieved data is processed using the CFA (confirmatory analysis factor) method. The result shows the five main factors that make Singapore attractive for medical tourism, and the factors are the atmosphere and medical accuracy, competency and price, facilities, customer satisfaction, and entertainment.
Traditional Balinese Architecture: From Cosmic to Modern
Authors: Hasudungan Irianto Sitinjak Ronald , Kusuma Wardani Laksmi , Firtatwentyna Nilasari Poppy
Published: April 2020

Balinese architecture often considers aspects of climate and natural conditions as well as environmental social life. This is to obtain a balance in the cosmos, between human life (bhuana alit / microcosm) and its natural environment (bhuana agung /macrocosm). However, Bali's progress in tourism has changed the way of life of the people, which is in line with Parsons Theory of Structural Functionalism, that if there is a change in the function of one part of an institution or structure in a social system, it will affect other parts, eventually affecting the condition of the social system as a whole. The shift in perspectives has caused structural and functional changes in Balinese architecture. The building design or architecture that emerges today is no longer oriented towards cosmic factors but is oriented towards modern factors, developing in the interests of tourism, commercialization, and lifestyle. The change has had an impact on spatial planning, building orientation, architectural appearance, interior furnishings and local regulations in architecture. In order to prevent Balinese architecture from losing its authenticity in its original form, which is full of spiritual meaning and local Balinese traditions, it is necessary to have a guideline on the specifications of Balinese architectural design that combines elements of aesthetics, comfort, technology, and spirituality. Through this guideline, Balinese architecture can exist in modern times without losing its traditional values.
Capital Structure Determinants in Property and Real Estate Company in 2013 to 2018
Authors: Ronni Basana Sautma , Tandarto Tiffany , Soehono Christina
Published: April 2020

This research is to recognize the factors supporting the property and real estate company in determining the capital structure composition. The population of this research is all the property and real estate company listed on the Indonesia Stock Exchange 2013 to 2018. There are 48 companies listed until 2019. The data analysis employs a stratum test. The results of this research are the company’s performance, profitability influencing the capital structure, growth that does not influence the capital structure, nondebt tax shield influencing capital structure, and liquidity does not influence capital structure. In the company’s risk, the collateral value of assets influences capital structure; on the other hand, the business risk does not influence the capital structure. In the company’s characteristics, company size does not influence the capital structure.
Infarktbedingter kardiogener Schock
Authors: Obradovic Danilo , Freund Anne , Desch Steffen , Thiele Holger
Published: April 2020

In patients admitted with acute myocardial infarction, cardiogenic shock remains the most common cause of death. Multidisciplinary care in a specialized center and guideline-compliant treatment of cardiogenic shock are crucial for the survival and prognosis of affected patients. Hemodynamic monitoring and stabilization by volume expansion, vasopressors and inotropes represent initial steps in the management of patients with cardiogenic shock. Nevertheless, early revascularization of the culprit-lesion is proved to be the most important treatment modality. Although the use of active mechanical circulatory support appears to be a promising therapeutic concept to improve clinical outcome in patients with infarct-related cardiogenic shock, in the few previous randomized trials mechanical circulatory support failed to show beneficial effects on short-term and long-term survival.
Lesões do Aquiles – Parte 1: Tendinopatias
Authors: Mansur Nacime Salomão Barbachan , Fonseca Lucas Furtado , Matsunaga Fábio Teruo , Baumfeld Daniel Soares , Nery Caio Augusto de Souza , Tamaoki Marcel Jun Sugawara
Published: April 2020

As afecções que acometem o tendão calcâneo são extremamente comuns na população geral e no cotidiano da atenção ortopédica. Sua crescente incidência, motivada pelo envelhecimento da população, pela melhora no acesso à saúde, pelo aumento na utilização de drogas de uso contínuo, pela errática participação esportiva e outros fatores, tem causado impacto direto na sociedade. As tendinopatias, ainda que hoje respaldadas por tratamentos consolidados, carecem de suporte científico de qualidade para muitas das suas recomendações. Novas terapêuticas têm surgido com o objetivo de potencializar o resultado da abordagem não-operatória e diminuir a quantidade de pacientes que necessitam de uma cirurgia. Esses procedimentos operatórios apresentam uma boa resposta álgica e funcional dos pacientes, no entanto não são livres de complicações e dos altos custos que os cercam.
IN VITRO FREE RADICAL SCAVENGING ACTIVITY OF BAUHINIA RACEMOSA
Authors: Bhaskar Bhagya , Avadhani Ramakrishna
Published: April 2020

In vitro free radical scavenging activity of aqueous and ethanolic bark extracts of Bauhinia racemosa was assessed by studying its ability to scavenge DPPH, Nitric oxide, hydroxyl radical and reducing power. Both the extracts showed effective free radical scavenging activity. Ethanolic extract was comparatively more potential than aqueous extract. The results support its traditional use in various ailments and as a source of natural antioxidants which protect cells against oxidative stress.
THE RELATIONSHIP BETWEEN DENTAL ARCH DIMENSIONS & INCISAL ABNORMALITIES TO THE MISARTICULATION OF CONSONANTS IN CHILDREN WITH ORAL CLEFTS
Authors: Shetty Amarshree , Rai Kavita , Hegde Amitha M. , Dattatreya T.
Published: April 2020

The objective of the present study was to evaluate the association between the dental arch dimensions and the incisal abnormalities or anomalies, to the consonant mis-articulations in children with unilateral cleft palate with the involvement of lip, before and after surgical correction.50 Non-syndromic children with unilateral cleft palate belonging to various experimental groups and 25 non-cleft children (control group) between the age group of 7-9 years were selected for the study. Dental arch dimensions were measured on the dental casts & the selected consonants were evaluated from all the four groups, by 3 qualified speech pathologists and then statistically analyzed. Reduction in the dental arch dimensions was observed in children with untreated cleft palate which further decreased after surgery. The correct production of all the selected consonants /ta/, /da/, /tha/, /dha/, /na/, /na/, /la/, /sa/ and /sha/ which was observed to be 15% in the untreated CP group, improved upto 52.4% after surgical correction in spite of the reduction in the dental arch dimensions. Speech analysis showed a high percentage of distorted sounds were maximum in untreated CP patients which decreased in surgically treated CP patients. Substituted sounds which was found to be absent in untreated cleft palate patients was observed in children who had undergone surgical correction of the palate Conclusion: the reduced arch dimensions and incisal abnormalities may be contributing factors which do not allow 100% normal speech in children with oral clefts.
NANOTECHNOLOGY : THE NEW ERA OF TECHNOLOGY
Authors: Kaira Laxman Singh , Singh Richa
Published: April 2020

Nanotechnology is a natural end result of scientific development and our ability to understand and manipulate matter at smaller and smaller level. Current research is directed towards the production of wide array of different nano-scale structures. The fabrication techniques of the structures can be divided into 2 approaches: “top-down” and “bottom-up.” New potential treatment opportunities in dentistry may include, local anesthesia, dentition re-naturalization, and permanent hypersensitivity cure, complete orthodontic realignments during single office visit, covalently bonded diamondised enamel, and continuous oral health maintenance using mechanical dentifrobots. Nanotechnology is foreseen to change health care in a fundamental way by providing novel methods for disease diagnosis and prevention, therapeutics selection, tailored to the patients profile, drug delivery and gene therapy.
TRADITIONAL SEASONAL HEALTH FOOD PRACTICES IN SOUTHWEST INDIA: NUTRITIONAL AND MEDICINAL PERSPECTIVES
Authors: B. Bhagya , A. Ramakrishna , R. Sridhar K.
Published: April 2020

The unique traditional practices of people belonging to Dakshina Kannada of Karnataka (Southwest India) utilize a variety of plant species for nutritional and medicinal purposes. This indigenous traditional knowledge (folklore/plantlore of food and medicine) is usually associated with rituals like 'Aati Amavasye'. Several plant species are used in a specific season as nutritional and or medicinal source. In changing time, such unique practices are disappearing and restricted largely to remote rural areas. Attention to identify the nutritional novelties, medicinal uniqueness, mode of formulations, and effectiveness of plant species need further exploration.