bluuebunny/crossref_metadata_2025 huggingface dataset:
Underground space optimization of smart city based on information processing technology
Authors: Li Zhiyong
Published: April 2021

This study explores the underground space optimization method of smart city based on information processing technology to save space optimization operation time. Taking coordinate of intersection point, radius of intersection point, mileage of vertical slope change point and elevation of slope change point as design variables, taking total cost of underground space construction of smart city as objective function and taking plane, vertical section, horizontal and vertical combination and environmental impact as constraint conditions, a multi-objective optimization mathematical model of underground space of smart city was constructed. Parete genetic algorithm in information processing technology was used to solve the multi-objective optimization mathematical model of the underground space of smart city, realize the automatic search for the optimal scheme of the underground space of smart city, and complete the intelligent optimization process of the underground space construction scheme of smart city. The results show that the method obtained from this study can effectively optimize the underground space of smart city and obtain the optimal subway laying line, save space and optimize operation time and improve the convergence of the method.
Convexity property and fixed-point theorems in CΩ-modular space
Authors: Hadi Sarem H. , Madhi Zainab S. , Park Choonkil
Published: April 2021

The purpose of this study is to introduce a new concept of the modular space, which is CΩ-modular space, and then some of the convex properties are discussed. We also study finding fixed-point in CΩ-modular space.
Early Gross Motor Milestones in Duchenne Muscular Dystrophy
Authors: Norcia Giulia , Lucibello Simona , Coratti Giorgia , Onesimo Roberta , Pede Elisa , Ferrantini Gloria , Brogna Claudia , Cicala Graziamaria , Carnicella Sara , Forcina Nicola , Fanelli Lavinia , Pane Marika , Mercuri Eugenio
Published: April 2021

Background:

Over the last few years there has been increasing attention to detect early signs of impairment in young Duchenne muscular dystrophy boys but less has been reported on whether the delay may also affect the very early aspects of motor development, such as gross motor milestones.

Objective:

The aim of this study was to retrospectively assess the age when early motor milestones were achieved in Duchenne muscular dystrophy.

Methods:

The study is a retrospective analysis of data collected as part of a larger natural history project. Information on past medical history, collected at the time the boys were seen for the first time, were recorded and re available on clinical notes and on electronic CRF.

Results:

Data were collected in 134 DMD boys. Sitting was achieved at 7.04 months. The % of DMD boys not achieving sitting by 9.4 months was 10%, ranging from 2% in the boys with mutations before exon 44 to 33% in those beyond exon 63. Walking was achieved at a mean age of 16.35 months. The % of DMD boys not achieving independent walking by 18 months was 17%, ranging from 9% in the boys with mutations between 44 and 51 to 42% in those beyond exon 63.

Conclusions:

Our results showed that the risk of a delay in sitting and walking was increasingly high in patients with mutations predictive of the involvement of different brain dystrophin isoforms.
Total variation with modified group sparsity for CT reconstruction under low SNR
Authors: Zhang Lingli
Published: April 2021

BACKGROUND AND OBJECTIVE:

Since the stair artifacts may affect non-destructive testing (NDT) and diagnosis in the later stage, an applicable model is desperately needed, which can deal with the stair artifacts and preserve the edges. However, the classical total variation (TV) algorithm only considers the sparsity of the gradient transformed image. The objective of this study is to introduce and test a new method based on group sparsity to address the low signal-to-noise ratio (SNR) problem.

METHODS:

This study proposes a weighted total variation with overlapping group sparsity model. This model combines the Gaussian kernel and overlapping group sparsity into TV model denoted as GOGS-TV, which considers the structure sparsity of the image to be reconstructed to deal with the stair artifacts. On one hand, TV is the accepted commercial algorithm, and it can work well in many situations. On the other hand, the Gaussian kernel can associate the points around each pixel. Quantitative assessments are implemented to verify this merit.

RESULTS:

Numerical simulations are performed to validate the presented method, compared with the classical simultaneous algebraic reconstruction technique (SART) and the state-of-the-art TV algorithm. It confirms the significantly improved SNR of the reconstruction images both in suppressing the noise and preserving the edges using new GOGS-TV model.

CONCLUSIONS:

The proposed GOGS-TV model demonstrates its advantages to reduce stair artifacts especially in low SNR reconstruction because this new model considers both the sparsity of the gradient image and the structured sparsity. Meanwhile, the Gaussian kernel is utilized as a weighted factor that can be adapted to the global distribution.
Теоретичні й практичні виміри «українського світу»: місце та роль релігії
Authors: Титаренко Віта
Published: April 2021

В статті розглядається питання онтології українського соціуму в контексті потенційного його виходу із стану сингулярності – він (соціум) має шанс перетворитися на щось позитивно інше, або так і залишитися у вимушено знайденому стані радикального збурення, із суттєво зміненим порядком речей, явищ, очікувань, сподівань. Цей процес характеризується наступною контроверсійністю: 1) наявністю високого ризику деструктивних змін, які мають релігійну основу; 2) наявністю потенціалу конструктивних змін, досвід якого накопичений та апробований самою історичною присутністю релігії.

Автор пропонує (з позицій філософсько-релігієзнавчих) пошук  життєздатних і емпірично дієвих концептів, спроможних об’єднати громадян країни (у їх етнічній, культурній, релігійній тощо багатоманітній ідентичності) у прагненні вивести український соціум із стану сингулярності в новій якості – з перспективами позитивних змін.

В статті аналізуються окремі теоретичні аспекти поняття «український світ», яке стає актуальним в середовищі релігієзнавців і його співвіднесеність з поняттями «нація», «українська нація», «етнічна нація», «громадянська (політична) нація», «національна ідея», «національна держава» тощо. В широкому розумінні «український світ» може розглядатися як простір єднання, співставний із загальнонаціональною ідентичністю, де індивід ототожнює себе з певними символами, цінностями, історією, територією, культурою, а також з державними та правовими інституціями, політичними й економічними інтересами.  Таке розуміння концепту «український світ» логічно виводить нас на необхідність аналізу практичної його складової. Послуговуючись даними соціологічних опитувань, статистичними даними, інтерв’ю, прикладами діяльності релігійних організацій і об’єднань – аналізується місце релігії в цьому просторі єднання, її потенціал, ризики, виклики.

Висновується, що «український світ» як простір єднання може і здатен формуватися за умов: 1) адекватної і зваженої політики з боку, перш за все, української держави – відповідно до Конституції, чинного законодавства, без преференцій для окремих конфесій (особливо на місцях), як шлях формування довіри до органів влади з боку конфесій; 2) розуміння і усвідомлення з боку представників церков і релігійних організацій своєї відповідальності перед українським суспільством, базування на універсальних загальнолюдських цінностях, здатних об’єднати українців та реалізація цих цінностей через практичну діяльність в суспільстві.
Рецензія на монографію «Церковно-політична історія Римських пап» (автор М.Отрош)
Authors: Яроцький Петро
Published: April 2021

В рецензії оглядається монографія українського історика М.Отроша  «Церковно-політична історія Римських пап» (Київ, 2019-2000, в трьох томах), аналізується основні ідеї і методологічні засади дослідження.
Автори часопису
Authors: Журналу Редколегія
Published: April 2021

Автори часопису
Титульна сторінка
Authors: Журналу Редколегія
Published: April 2021

Титульна сторінка
Perancangan Prototipe Kapal Remote Control Pemberi Pakan pada Budidaya Benih Ikan Mas Berkapasitas Muatan 2 Kg Menggunakan Metode Perbandingan dengan Skala 1:25
Authors: Kasda Kasda , Susanto Susanto , Bekti Ari Aji
Published: April 2021

Pemberian pakan dengan cara ditabur secara manual oleh orang sambil berjalan mengelilingi kolam untuk mendekati gerombolan ikan, menjadi tidak efektif karena dapat menguras waktu dan tenaga terutama bagi pembudidaya yang memiliki banyak kolam. Perancangan prototipe kapal remote control pemberi pakan dilakukann untuk memberikan solusi dalam meningkatkan efektifitas dan efisiensi proses pemberian pakan pada benih ikan usia 11-18 hari. Sebagai tahap awal penelitian, proses perancangan dilakukan untuk menentukan ukuran utama prototipe kapal yang dapat mambawa muatan maksimum pakan sebear 2 kg dan kecepatan operasi sebesar 0,81 m/s . Dari hasil perancangan dengan metoda perbandingan (skala 1:25) dan beberapa langkah modifikasi didapat ukuran utama kapal yaitu L=0,7m, B=0,22m, H=0,1m dan T=0,05, Cb=0,66 dengan displacement sebesar 5,67 kg. Hambatan kapal dihitung menggunakan metode holtrop. Pada kecepatan operasi kapal sebesar 0,81 m/s didapat hambatan sebesar 0,337 N. Dengan demikian efektif daya (EHP) dapat ditentukan sebesar 0,237 watt.
Analisa Konsumsi Daya Sistem Penerangan Mobil Gentayu UNDIP pada Saat Hujan dan Tidak Hujan untuk Mendapatkan Jenis Lampu yang Memiliki Efesiensi Daya
Authors: Setiyawan Trio , Indrawati Ragil Tri
Published: April 2021

Mobil listrik Gentayu UNDIP sumber utama penggeraknya adalah baterai maka dari itu untuk membuat efesiensi penggunaan daya baterainya dibutuhkan analisa konsumsi daya pada perangkat kelistrikan pendukung mobil listrik gentayu UNDIP. Pada saat penggunaan malam konsumsi daya akan bertambah karena pengunaan sistem penerangan terlebih lagi ketika kondisi hujan ada sistem pendukung lain yaitu system wiper yang harus bekerja oleh karena itu dengan kondisi tersebut dibutuhkan penelitian untuk mencari efesiensi penggunaan daya baterai dimana penilitian ini belum pernah dilakukan pada mobil Listrik Gentayu UNDIP. kami akan mencoba untuk menganalisa jenis lampu yang tempat untuk sistem penerangan pada mobil listrik Gentayu UNDIP, untuk mendapatkan jenis lampu yang Efesiensi daya dan memiliki intensitas cahaya yang tinggi ujicoba yang dilakukan adalah dengan cara melakukan perhitungan langsung konsumsi daya jenis lampu filament dan lampu LED dengan tambahan system wiper bekerja atau tidak bekerja. Perhitungan konsumsi baterai dan intensitas cahaya pada jarak antara tinggi 100cm dari 67.9 cm pada dua jenis penerangan, yaitu lampu jenis LED dan lampu jenis fillamen pada tegangan maksimum baterai 12,30 volt menggunakan baterai 12 Volt 35 Ah. Hasil penelitian menunjukkan lampu filament dengan kodisi wiper hidup memiliki intensitas cahaya sekitar 850 Lux pada tegangan awal 12,30 Volt dan turun menjadi 720 Lux dengan tegangan menjadi 11,86 Volt setelah dinyalakan selama 60 menit. Sedangkan lampu LED memiliki intensitas cahaya sekitar 1690 Lux pada tegangan awal 12,30 Volt dan setelah menyala selama 60 menit intensitas cahaya menjadi 160 Lux dengan tegangan 12,10 Volt. Dapat disimpulkan bahwa penggunaan lampu LED dalam kondisi kondisi hujan dengan hidupnya wiper lebih memiliki efisiensi daya lebih ketimbang lampu Fillamen dalam kondisi yang sama dan lampu LED memiliki Lument cahaya yang lebih tinggi. Penurunan tegangan untuk konsumsi lampu LED dengan kondisi hujan atau wiper bekerja cenderung lebih lambat yaitu 0,20 Volt untuk pemakaian 1 jam, dibandingkan dengan lampu halogen 0,46 Volt untuk pemakaian 60 Menit.
Cloud solutions of 1C company as a basis for implementation of a system approach in the preparation of a specialist
Authors: Apolov O. G. , Apolova O. O.
Published: April 2021

The article determines the relevance of a system approach in the training of a specialist in the field of managing economic objects. Despite the huge number of university graduates with diplomas in the field of economics and management, in recent years there has been a widespread deficit of qualified specialists. Even successful graduates, possessing a sufficiently large amount of theoretical knowledge in the field of economics and management, are not able to apply this knowledge to solve practical problems of modern business. The main reason for this is the creation of curricula in many educational institutions as a set of disciplines read in different semesters without taking into account their interrelationships and without reference to the main target function of vocational education that is the formation of a specialist. This problem is especially acute in regions where the main “consumers” of educational institutions’ services are mini- and microbusiness, which requires mastering a wide range of practice oriented competencies based on the widespread use of information technologies. The most important, according to the authors, the requirements of mini- and microbusiness, as a potential employer of most graduates of educational institutions of economic profile, to potential employees, are formulated in the article. The work is based on the experience of using the cloud service edu.1CFresh from the 1C company in order to implement a system approach in training specialists in the field of economics and management. The capabilities of the service showed themselves especially brightly during the period of pandemic restrictions, the use of the service made it possible to maintain and even to some extent increase the effectiveness of training due to the redistribution of lectures and practical classes. The service acts as a technological basis for the formation of models of real business processes and is the center around which the knowledge gained in the study of special disciplines is collected. The article discusses the methods for organizing various forms of educational activities using the edu.1CFresh service in the process of training bachelors in “Management” and “Economics” directions.
Organization of the university educational environment in the context of the COVID-19 pandemic
Authors: Zolotaryuk A. V.
Published: April 2021

The article reveals issues related to the impact of the COVID-19 pandemic on various aspects of human activity. The necessity of transferring at the peak of diseases of educational institutions to the distance format of conducting classes is substantiated. Studying the articles of a number of authors, the high efficiency of distance learning for high school students and university students is noted; the forms of distance learning in various universities of the world and the problems of such learning are revealed; attention is focused on the possibilities of using a hybrid learning model in the educational process with preliminary recording of lectures on YouTube and conducting classes online using the Teams, Skype, Zoom technology platforms; an assessment of the perception of innovative digital technologies by teachers and students is carried out; it is proposed to submit practically significant, complex tasks for exams that require research and the use of competencies by students of several specialized disciplines.Considerable attention is paid to the organization of the educational process at the Financial University under the Government of the Russian Federation. It is noted that many problems of the transition to distance learning were avoided thanks to the advance, systematic and purposeful work to form the university digital environment. The general technological scheme of the educational process of the university in a pandemic is illustrated and disclosed in detail. Information about specialized programs and packages that support the educational process is provided. The role of 1C software products, 1C cloud solutions, which support many basic disciplines in various areas of student training, is especially noted. The possibilities and directions of students’ research work in the field of data analysis and machine learning are revealed. It is concluded that the transition of education to distance learning has not become critical for the Financial University. The University continues to train highly-demanded qualified personnel.
Formation of professional competencies of bachelors of the “Applied informatics” direction in the implementation of distance learning using software on the 1C:Enterprise platform
Authors: Kovalev E. E. , Kovaleva N. A.
Published: April 2021

The objectives of the implementation of the National Project “Digital Economy” are the modernization of the education system and the introduction of modern technologies and teaching aids. The article discusses the achievement of these goals in the modern conditions of the organization of the educational process, which require the introduction of models of distance and blended learning using practice oriented methods. To form the competencies of bachelors in the “Applied informatics” direction, a practice oriented learning model has been developed based on 1C software products, based on the matrix of correspondence between curriculum disciplines and information systems and services offered by the developer. When implementing such a model, it is necessary to use the methodology of a continuous system for the formation of professional competencies, which consists of several stages, which also include all types of planned practice curricula. Successful achievement of the set goals is possible due to the integration of practical examples and software solutions, which allows solving professional problems without the departure of students to enterprises. The experience of organizing student training on practice oriented cases within the framework of the formation of professional competencies of graduates of the direction of training bachelors “Applied informatics” is presented. The features of the proposed solutions in the implementation of interdisciplinary links of IT disciplines using the 1C:Enterprise platform are considered.
Mathematical modeling in informatiсs lessons using numerical solution of differential equations
Authors: Kulabukhov S. Yu.
Published: April 2021

The article considers the author's fragment of an in-depth course of informatics in a physics and mathematics school. It is based on the use of differential equations to model complex physical processes. Three models are considered: a mathematical spring pendulum, the orbital motion of the satellite around the planet and the movement of the body in the atmosphere taking into account air resistance. Since in the in-depth course of mathematics of the physics and mathematics school, numerical methods for solving differential equations are not studied, the article proposes to use the simplest method — the Euler method. Using this method, the resulting differential equations in each case are numerically solved. Since differential equations arising in each model have a second order, in order to apply the Euler method, it is necessary to reduce the order of differential equations by introducing new variables. In this case, instead of one differential equation of the second order, a system of two equations of the first order arises. For each built model, its implementation in the PascalABC.NET programming language is given.
Characteristic of basic tools of mobile learning in informatics
Authors: Izhdeneva I. V.
Published: April 2021

The article actualizes the possibilities of mobile learning based on the use of mobile devices and technologies available to almost all students. Various approaches to the definition of the concept of "mobile learning" are analyzed, including techno-centric and information-centric approaches. The concept of mobility as one of the attributes of learning tools is revealed. The importance of mobile learning in the current difficult situation of distance learning during the pandemic is substantiated. The characteristic features of mobile learning are highlighted, affecting its main functions, learning tools and independence from the time and place of learning. Possible directions for the implementation of mobile learning are characterized, from simple transfer of educational content to compliance with basic educational theories. From the point of view of the functioning and directions of development of mobile learning, its basic principles in teaching informatics are formulated. The types of students' activities are briefly characterized; some advantages of mobile learning are highlighted and its features as visualization, interactivity, efficiency of use in teaching children with disabilities are characterized. Some popular educational apps for mobile devices are considered, their characteristics are given, and their educational potential is revealed. Examples of mobile applications are given, the use of which in informatics lessons will help to activate the educational and cognitive activity of students and stimulate them to engage in informatics, coding and robotics.
Geography Teachers' Skills in Developing HOTS-Oriented Assessment Instruments in Metro City
Authors: Suhendro Suhendro , Sugandi Dede , Ruhimat Mamat
Published: April 2021

HOTS-oriented assessment is to improve students' high-level thinking skills in the classroom. The purpose of this study is to determine and analyze the skills of geography teachers in developing HOTS-oriented questions both theoretically and practically. The results show that their skills are theoretically and practically low. Teachers’ training to improve their competence in developing HOTS-oriented assessment instruments is necessary.
Differentiation of Mesenchymal Stem Cells Derived From Human Adipose Tissue Into Cholinergic-like Cells; in vitro
Authors: Sanooghi Davood , Amini Naser , Azedi Fereshteh , Bagher Zohreh , Parvishan Asghar , Lotfi Abolfazl , Rashidi Nooshin , Lotfi Erfan , Faghihi Faezeh
Published: April 2021

Cholinergic associated diseases currently are major cause of neurological and neurodegenerative disabilities. As the drugs are not efficient in improving the suffered tissues, stem cell treatment is considered as an effective strategy for substituting the lost cells. In the current study, we set out to investigate the differentiation properties of human adipose-derived mensenchymal stem cells (AD-MSCs) into cholinergic-like cells by two morphogens; including retinoid acid (RA) and Sonic hedgehog (Shh) using a three- step in vitro procedure. The results were evaluated using Real-time PCR, Flowcytometry and Immunocytochemistry for two weeks. Our data showed that the cells could express cholinergic specific markers; including Islet-1, AChE, SMI-32 and Nestin at the level of mRNA and protein. We could also quantitatively evaluate the expression of Islet-1, AChE and Nestin at 14 days post- induction using flowcytometry. It is concluded that human AD-MSCs are potent type cell to differentiate into cholinergic like cells in the presence of RA and Shh through a three- step protocol; thus it could be a suitable cell candidate for regeneration of cholinergic associated diseases; however, more functional and electrophysiological analysis are needed.
Evaluating the Effects of Epigallocatechin-3-Gallate on HIF-1α Protein and RORC Gene Expression in Peripheral Blood Mononuclear Cells in Patients With Multiple Sclerosis
Authors:   Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Afshar Boshra , Ganjalikhani-Hakemi Mazdak ,   Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Khalifezadeh Esfahani Zahra ,   Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Eskandari Nahid ,   Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Shaygannajad Vahid ,   Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Hosseininasab Fahimeh ,   Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Alsahebfosoul Freshteh ,   Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.,   Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Published: April 2021

Introduction: Multiple Sclerosis (MS) is the chronic inflammation of the Central Nervous System (CNS) and autoimmune disease. MS is most widely considered to be mediated by the activation of myelin-specific T CD4+ cells as well as TH1 and TH17 cells. TH17 cells are involved in the pathogenesis of MS in various manners. HIF-1α and RORC are required for the natural differentiation of TH17; they are essential transcription factors for the evolution of TH17 cells. Numerous studies indicated that Epigallocatechin Gallate (EGCG) presents immunomodulatory and anti-inflammatory effects. This study investigated the effects of EGCG on normoxic HIF-1α and RORC2 expression in PBMCs among MS patients. Methods: Peripheral Blood Mononuclear Cells (PBMCs) were isolated from the whole blood of new cases of MS. The cells were cultured in the presence of a different concentration of EGCG (25, 50,100μM) for 18 and 48 hours. Next, HIF-1α and RORC2 level expressions were measured by Enzyme-Linked Immunosorbent Assay (ELISA) and Real-Time PCR, respectively. Results: The results showed that EGCG significantly decreased RORC2 gene expression. EGCG did not affect the level of HIF-1α. Conclusion: However, EGCG did not influence the level of HIF-1α. Our present data has led us to conclude that EGCG could be considered as an anti-inflammatory agent may serve as an achievable therapeutic agent for MS.
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker
Authors:   Aja University of Medical Sciences, Tehran, Iran., Mirzaii-Dizgah Mohammad-Hosein , Mirzaii-Dizgah Mohammad-Reza ,   Iran University of Medical Sciences, Tehran, Iran., Mirzaii-Dizgah Iraj ,   Aja University of Medical Sciences, Tehran, Iran.
Published: April 2021

Objective: Multiple sclerosis (MS) is considered as motor and sensory function loss, which results from demyelination and following axonal lesion. As Myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated and unstimulated saliva as a suitable biomarker for detecting of MS. Methods: A case–control study was performed in 29 healthy women and 32 definitive relapsing-remitting MS patients who were hospitalized in Imam Reza hospital, Tehran, Iran. MBP level was assayed in serum and stimulated and unstimulated whole saliva. Results: MBP was expressed at a lower level in serum and stimulated saliva of MS patients compared to control groups. The serum MBP level had a considerable correlation with its stimulated saliva level. The receiver operating characteristic analysis showed significantly diagnostic abilities for MBP to discrimination MS patients with serum and stimulated saliva from controls. Conclusions: Serum and saliva level of MBP is lower in MS and it may be considered as a potential biomarker in Multiple sclerosis.
Implementation of the Project “Community Police Officer”: Real Actions to Bring Police Service Closer to People (on the example of Kharkiv oblast)
Authors: Holub M. V.
Published: April 2021

The author has studied the issue of further approach of the police service to the people – members of the united territorial community. The emphasis has been placed on the need to take further steps to strengthen partnership between the police and community members. Special attention has been paid to the important role of the National Police in the process of implementing the decentralization, taking measures to ensure public order and security in the territories of united communities, taking into account the views, positions and recommendations of residents of united territorial communities, the importance of interaction between community police officers and the population. The author has highlighted the importance of the pilot project “Community Police Officer” to further increase of public confidence in the police. The author has suggested appropriate measures for more effective promotion of this project, in particular: to initiate for the Department of the National Police of Ukraine to take measures aimed at creating a legal base that can ensure the effective operation of community police officers according to the legal point of view, as well as their interaction with other law enforcement agencies, introducing relevant amendments into existing regulatory documents; to prepare propositions in regard to these provisions; to develop routes and time of foot patrol by community police officers of the assigned territory, taking into account the analysis of street offenses, the location of places visited by a significant number of residents of the united territorial communities and other features of a particular united community; to make propositions for the creation of a “basic” united territorial communities in Kharkiv oblast, in terms of community police officers’ activities, to initiate and provide assistance to the Department of Preventive Activities of the Main Directorate of the National Police in Kharkiv oblast in organizing and conducting practical classes with this category of employees with visiting the specified united territorial communities; to introduce training of community police officers on the basis of Kharkiv National University of Internal Affairs, to prepare appropriate educational and methodical material; to improve the work of community police officers to ensure effective exchange of information, opportunities to quickly make decisions in case of complications, create an Internet group in the application “Telegram”, which should include police officers working within the pilot project “Community Police Officer”.
Atividade antifúngica de Cymbopogon citratus (DC) Stapf frente à leveduras do gênero Candida sp.
Authors: Paiva Luiz Francisley de , Domingues Sabrina de Alvarenga
Published: April 2021

Candida sp. é um gênero de levedura que faz parte da microbiota do corpo humano e de animais. É considerado o principal grupo de fungos patógenos oportunistas. O uso de plantas medicinais é empregado cada vez mais nas diversas áreas. A planta Cymbopogon citratus (DC). Stapf é popularmente conhecida no Brasil por Capim-cheiroso, Capim-cidreira, Capim-santo, Capim-limão, Capim-cidró, Capim-cidrão. Este estudo teve como objetivo avaliar a atividade antifúngica do óleo essencial de Cymbopogon citratus frente a leveduras do gênero Candida sp.. O óleo essencial foi obtido por hidrodestilação das folhas pelo método do arraste a vapor. A atividade antifúngica foi verificada pelas técnicas de disco-difusão, concentração inibitória mínima e concentração letal mínima. Foram utilizadas as cepas padrão ATCC de Candida albicans, Candida dubliniensis, Candida tropicalis, Candida glabrata, Candida Krusei, Candida parapsilosis e Candida utilis. O óleo essencial apresentou atividade antifúngica frente a todas as espécies. A faixa de inibição varia de 0,281 µg/mL a 1,125 µg/mL e concentração letal varia de 0,562 µg/mL a 1,125 µg/mL. Esses achados contribuem para um futuro emprego da planta C. citratus como fitoterápico em tratamento preventivo ou alternativo contra infecções fúngicas.
Análise do Fundo Constitucional de Financiamento do Norte como instrumento para o Desenvolvimento Regional
Authors: Cardoso Leandro dos Santos
Published: April 2021

Os Fundos Constitucionais de Financiamento são instrumentos utilizados na busca pelo desenvolvimento das regiões brasileiras, historicamente afetadas pelo crescimento desigual do país. O FNO, especialmente, dedica-se ao crescimento e desenvolvimento econômico e social da região norte, por meio de financiamentos em infraestrutura e produção. Assim, com o objetivo de verificar a efetividade da política pública para o desenvolvimento da região norte buscou-se através da revisão bibliográfica dos principais artigos da área, analisar os principais resultados e conclusões, os quais apontaram que não é possível afirmar de forma clara a relação positiva entre o financiamento e o desenvolvimento regional, além disso, vários estudos demonstrarem que o fundo influenciou no aumento das desigualdades inter-regionais nos períodos analisados.
Neutrophil to Lymphocyte Ratio in Preeclampsia
Authors: Prasetyo Alfian , Bororing Sheella Rima , Sukadarma Yuma
Published: April 2021

Abstract

Objective: To determine the correlation between neutrophil to lymphocyte ratio and preeclampsia. To determine whether neutrophil to lymphocyte ratio can be used as a screening tool for preeclampsia.Methods: This study was conducted with a systematic review method. Articles that had been gathered and filtered were reviewed by QUADAS-2 tool. Guidelines from the American Congress of Obstetricians and Gynecologists (ACOG) and Pedoman Nasional Pelayanan Kedokteran were used as a diagnostic criteria for determining preeclampsiaResults: Studies conducted by Kirbas et al, Cakmak et al, Wang et al and Panwar et al stated that there is a correlation between neutrophil to lymphocyte ratio to preeclampsia (p-value < 0.05). Cut-off values are diverse between 3.5 - 5.6 with different sensitivity and specificity.Conclusion: This systematic review shows that there is a relationship between neutrophil to lymphocyte ratio and preeclampsia. Neutrophil to lymphocyte ratio can be used as screening tools for preeclampsia in the first trimester.Keywords: neutrophil to lymphocyte ratio, NLR, preeclampsia.

Abstrak

Tujuan: Mengetahui apakah terdapat hubungan antara rasio neutrofil terhadap limfosit dengan preeklampsia. Mengetahui apakah rasio neutrofil terhadap limfosit dapat dijadikan sebagai alat bantu skrining preeklampsia.Metode: Penelitian ini dilakukan dengan metode systematic review. Artikel yang disaring akan ditentukan kualitasnya menggunakan QUADAS-2. Kriteria diagnostik preeklampsia yang digunakan adalah American College of Obstetricians and Gynecologists (ACOG) untuk penelitian luar negeri dan Pedoman Nasional Pelayanan Kedokteran untuk penelitian dalam negeri.Hasil : Penelitian yang dilakukan oleh Kirbas et al, Cakmak et al, Wang et al, dan Panwar et al menyatakan bahwa terdapat hubungan antara rasio neutrofil terhadap limfosit dengan preeklampsia ( p-value < 0.05). Nilai cutoff dari rasio neutrofil terhadap preeklampsia beragam mulai dari 3.5 - 5.6 dengan sensitivitas dan spesifisitas yang berbeda-beda.Kesimpulan : Penelitian systematic review ini menunjukan bahwa rasio neutrofil terhadap limfosit memiliki hubungan dengan penyakit preeklampsia. Rasio neutrofil terhadap limfosit dapat dijadikan sebagai alat bantu skrining untuk preeklampsia pada trimester pertama.Kata kunci: rasio neutrofil terhadap Limfosit, NLR, preeklamsia.
Perfil epidemiológico dos portadores de sífilis entre 2010 e 2018 no Estado do Paraná, Brasil
Authors: Ito Fernanda Yuki , Gonçalves Maryna Rodrigues , Gonçalves Mayara Rodrigues , Hirota Michely Mika , Hayashida Mariana Rie , Mizoguti Nathália Nakase , Nasr Acácia Maria Lourenço Francisco
Published: April 2021

A sífilis é uma doença infecto contagiosa de transmissão sanguínea, sexual e vertical. O estudo teve por objetivo analisar os casos de sífilis no estado de Paraná entre os anos de 2010 e 2018, e descrever o perfil epidemiológico dos infectados. O estudo é quantitativo, descritivo e observacional desenvolvido com dados secundários do Sistema Nacional de Agravos de Notificação (SINAN), avaliando a taxa de detecção da sífilis adquirida. Entre 2010 e 2018 o Paraná registrou 39.900 casos de sífilis adquirida, sendo que 58,5% ocorreram em homens e 41,5% em mulheres.  A faixa etária de maior incidência foi entre 20-29 anos (26,9%), seguida por 30-39 anos (21,4%). A maioria dos infectados possuía como nível de escolaridade o ensino fundamental e médio (18,5% e 19%, respectivamente). A macrorregião leste do Estado apresentou a maior incidência de casos (59,28% dos casos em 2016). Quanto às Regionais de Saúde, as taxas de detecção mais elevadas no ano de 2016 foram observadas em Cascavel, Metropolitana e Ponta Grossa. Devido ao aumento de casos de sífilis adquirida no Paraná entre os anos de 2010 a 2018, é necessário o direcionamento de ações de prevenção e rastreio.
Extracting an Optimal Set of Linguistic Summaries using Genetic Algorithm Combined with Greedy Strategy
Authors: Lan Phạm Thị
Published: April 2021

The goal of extracting linguistic data summaries is to produce summary sentences expressed in natural language which represent knowledge hidden in numerical dataset. At the most general level, human users can get a very large number of linguistic summaries. In this paper, we propose a model of genetic algorithm combined with greedy strategy to extract an optimal set of linguistic summaries based on the evaluation measures of goodness and diversity of the set of linguistic summaries. The experimental results on creep dataset have demonstrated the outperformance of the proposed model of genetic algorithm combined with greedy strategy in comparison with the existing genetic algorithm models in extracting linguistic summaries from data.
Perbedaan Densitas Tulang Alveolar Sebelum dan Sesudah Kuretase Menggunakan Software ImageJ Pada Periodontitis Kronis
Authors: Astuti Lilies Anggarwati , Masriadi Masriadi , Arifin Fadil Abdillah , Aslan Sarahfin , Hikmah Nurul
Published: April 2021

Latar belakang : Penyakit periodontal adalah penyakit yang kehilangan struktur kolagennya pada daerah yang menyangga gigi, sebagai respon dari akumulasi bakteri di jaringan periodontal.  periodontitis adalah penyakit infeksi kronis yang dapat menghancurkan jaringan periodontal termasuk ligamen periodontal dan rongga alveolar gigi. Tujuan : Untuk mengetahui bagaimana perbedaan gambaran radiografis periodontitis kronis sebelum dan sesudah perawatan berdasarkan densitas tulang menggunakan software imagej. Bahan dan metode penelitian : Penelitian ini bersifat analisis observasional dengan menggunakan pendekatan Cross sectional study.Sampel didapatkan dengan menggunakan metode pengambilan sampel koutasampling. Radiograf digitalisasi menggunakan software ImageJ untuk melihat perbedaan luas trabekula kemudian dilakukan uji Paired T-Test. Hasil Penelitian : Terdapat perbedaan nilai rata-rata densitas tulang sebelum dan sesudah perawatan kuretase yaitu 525,20 pixel. adapun rata-rata densitas tulang sebelum perawatan kuretase yaitu sebesar 1882,10 pixel dan sesudah perawatan menjadi 1356,90 pixel. Hasil uji Paired Sampel T-Test juga menunjukkan signifikansi perbedaan luas antara densitas tulang sebelum dan sesudah dilakukan perawatan kuretase, dimana terdapat p-value yang menujukkan nilai p=0,003. Nilai P-Value menunjukkan kurang dari 0,05 artinya bahwa terdapat perbedaan yang sangat signifikan antara densitas tulang sebelum dan sesudah perawatan kuretase. Kesimpulan : Terdapat perbedaan signifikan gambaran radiografis peridontitis sebelum dan sesudah perawatan kuretase pada perubahan luas trabekula menggunakan software ImageJ  di RSIGM UMI tahun 2020.
Perbedaan Skor Plak Sebelum dan Setelah Mengunyah Buah Naga Putih pada Anak 10-11 Tahun
Authors: Pamewa Kurniaty , Masriadi Masriadi , Bachtiar Rachmi , Pertiwisari Amanah , Aslan Sarahfin , Anas Risnayanti , Iprab Ika Hartati
Published: April 2021

Pendahuluan. Masalah kesehatan gigi dan mulut merupakan hal yang sangat penting, terutama pada anak usia sekolah dasar. Anak-anak usia sekolah dasar 9-12 tahun yang telah memiliki gigi permanen belum terbiasa menyikat gigi dengan baik dan benar namun mereka telah memiliki pemahaman yang baik akan pentingnya menjaga kebersihan gigi dan mulut. Masalah dalam rongga mulut khususnya gigi diawali dengan adanya plak. Plak adalah lapisan yang melekat pada permukaan gigi yang mengandung bakteri. Pencegahan penumpukan plak dilakukan dengan kontrol plak, salah satu bahan alami yang dapat digunakan adalah buah naga putih (Hylocereus undatus), pada buah naga ini memiliki kandungan nutrisi yang kaya khususnya vitamin C, fosfor, kalsium serta memiliki antioksidan yang tinggi serta memiliki kandungan antibakteri, betacinin, dan flavonoid. Tujuan: Untuk mengetahui perbedaan skor plak sebelum dan sesudah mengunyah buah naga putih (Hylocereus undatus) pada anak usia 10-11 tahun. Bahan dan Metode. Mengunakan metode quasi experimental dengan bentuk penelitian pre posttest control group design dan pengambilan sampel dengan purposive sampling dengan jumlah sampel 84 responden. Hasil. Berdasarkan hasil pengujian menggunakan uji Wilcoxon diperoleh hasil p-value sebesar 0,000 yang lebih kecil dari pada 0,05. Nilai rata-rata skor plak sebelum perlakuan 0.829 sedangkan sesudah perlakuan memiliki nilai rata-rata skor plak sebesar 0.666. Kesimpulan: Hipotesis alternatif penelitian ini diterima dan hasil penelitian ini menunjukkan bahwa terdapat perbedaan skor plak sebelum dan sesudah mengunyah buah naga putih (Hylocereus undatus) pada anak usia 10-11 tahun.
Selenium supplementation to improve bone health in postmenopausal women: the SeMS three-arm RCT
Authors: Walsh Jennifer S , Jacques Richard , Schomburg Lutz , Hill Tom , Mathers John , Williams Graham , Eastell Richard
Published: April 2021

Background

Observational and pre-clinical studies have reported an association between selenium status, bone density, bone turnover and fracture risk. Selenium is an anti-oxidant, so we hypothesised that selenium could reduce the pro-resorptive action of reactive oxygen species on osteoclasts. Population mortality data suggest that the optimum range for serum selenium is 120–150 µg/l. Most adults in Europe are relatively selenium insufficient compared with adults in the USA and other geographical areas.

Objectives

The objectives of the study were to determine if selenium supplementation in postmenopausal women with osteopenia decreased bone turnover, improved physical function or decreased markers of oxidative stress and inflammation.

Design

We conducted a 6-month double-blind, randomised, placebo-controlled trial.

Setting

This was a single-centre study in Sheffield, UK.

Participants

We recruited 120 postmenopausal women with osteopenia or osteoporosis. One hundred and fifteen women completed follow-up and were included in the intention-to-treat analysis.

Interventions

The interventions were sodium selenite as Selenase 200 µg/day, Selenase 50 µg/day (biosyn, Germany) and placebo.

Main outcome measures

The primary end point was urine N–terminal cross-linking telopeptide of type I collagen/Cr (NTX/Cr) at 26 weeks. Groups were compared with an analysis of covariance, through the use of Hochberg testing. Secondary end points were other biochemical markers of bone turnover, bone mineral density by dual-energy X-ray absorptiometry and physical function scores (short physical performance battery and grip strength). The mechanistic end points were markers of inflammation and anti-oxidant activity (glutathione peroxidase, highly sensitive C-reactive protein and interleukin 6).

Results

In the 200 µg/day group, mean serum selenium increased from 78.8 µg/l (95% confidence interval 73.5 to 84.2 µg/l) to 105.7 µg/l (95% confidence interval 99.5 to 111.9 µg/l) at 26 weeks. Urine NTX/Cr did not differ between treatment groups at 26 weeks. None of the secondary or mechanistic end-point measurements differed between the treatment groups at 26 weeks.

Conclusions

We conclude that selenium supplementation at these doses does not affect bone turnover (assessed by NTX/Cr) and is not beneficial for musculoskeletal health in postmenopausal women.

Trial registration

IRAS 200308, EudraCT 2016-002964-15 and ClinicalTrials.gov NCT02832648.

Funding

This project was funded by the Efficacy and Mechanism Evaluation (EME) programme, a MRC and National Institute for Health Research (NIHR) partnership. This will be published in full in Efficacy and Mechanism Evaluation; Vol. 8, No. 6. See the NIHR Journals Library website for further project information.
ДЕЯКІ АСПЕКТИ КРИМІНАЛЬНО-ПРАВОВОЇ КВАЛІФІКАЦІЇ КОРУПЦІЙНИХ ЗЛОЧИНІВ
Authors: Аракелян Р. Ф.
Published: April 2021

Стаття присвячена висвітленню деяких аспектів кримінально-правової кваліфікації корупційних злочинів. Досліджено вітчизняні доктринальні підходи, процеси та форми прояву кримінально-правової кваліфікації корупційних злочинів, запропоновано правила розмежування конкретних складів корупційних злочинів та правила здійснення кримінально-правової кваліфікації корупційних злочинів. Обґрунтовано необхідність здійснення кримінально-правової кваліфікації корупційних злочинів на засадах синергетичного ефекту.
ОКРЕМІ АСПЕКТИ СТАНОВЛЕННЯ МІЖНАРОДНОЇ СПІВПРАЦІ У ЗАПОБІГАННІ ЗЛОЧИННОСТІ
Authors: Дідківська Г. В.
Published: April 2021

У цій статті аналізується становлення кримінального законодавства та його уніфікація, яка відбувалася невеликими темпами, що стосувалося надзвичайної особливості питань суверенітету кожної окремої держави та їх кримінально-правових політичних питань. Зазначається, що загальною ознакою таких домовленостей про однорідне кримінальне законодавство та узгодженість діяльності є міждержавні договори, які передбачають призначення покарання та кваліфікації діянь як протиправних міжнародними чи національними правоохоронними органами. Їх основним завданням є сприяння забезпеченню однаковості кримінального законодавства держав у спосіб конструювання змістовних особливостей кримінального правопорушення.
СВОБОДА, РІВНІСТЬ, СПРАВЕДЛИВІСТЬ ЯК ОСНОВНІ ЕКЗИСТЕНЦІЇ ГУМАНІСТИЧНОГО ПОТЕНЦІАЛУ ПРАВА
Authors: Тартасюк В. Ю.
Published: April 2021

У статті проаналізовано основні критерії розуміння таких понять, як свобода, рівність, справедливість. Визначено, що свобода, рівність, справедливість як основні екзистенції гуманістичного потенціалу права являють собою конкретизовані у правових ідеалах вищі моральні цінності. Вони визначають систему поведінкових стандартів, за якими члени суспільства мають діяти у відповідних ситуаціях, щоб їх інтереси узгоджувалися з інтересами та потребами інших людей, держави і громадськими інтересами.
ДІДЖИТАЛІЗАЦІЯ ЯК ЗАСІБ ПІДВИЩЕННЯ ВІДКРИТОСТІ, ПРОЗОРОСТІ ТА ЕФЕКТИВНОСТІ ДІЯЛЬНОСТІ ОРГАНІВ ДЕРЖАВНОЇ ВЛАДИ ТА ОРГАНІВ МІСЦЕВОГО САМОВРЯДУВАННЯ ЩОДО НАДАННЯ ЕЛЕКТРОННИХ ПОСЛУГ
Authors: Литвин Н. А. , Крупнова Л. В.
Published: April 2021

У статті досліджується поняття діджиталізації як засобу підвищення відкритості, прозорості та ефективності діяльності органів державної влади й органів місцевого самоврядування щодо надання електронних послуг. Виділено переваги та недоліки впровадження діджиталізації в діяльність органів влади. Запропоновано ряд організаційних та технічних заходів, направлених на подолання цих недоліків.