bluuebunny/crossref_metadata_2025 huggingface dataset:
Cefepime-Induced Encephalopathy and Nonconvulsive Status Epilepticus: Dispelling an Artificial Dichotomy
Authors: Tchapyjnikov Dmitry , Luedke Matthew W.
Published: October 2018

Cefepime is a fourth-generation cephalosporin antibiotic known to have neurotoxic side effects. Recent reports have described patients on cefepime presenting with altered mentation and concurrent triphasic wave discharges on electroencephalogram (EEG). Some have described this clinical presentation as cefepime-induced encephalopathy, while others have termed it as cefepime-induced nonconvulsive status epilepticus (NCSE). We report on 4 patients who developed cefepime-associated altered mentation with triphasic discharges on EEG. A benzodiazepine trial was attempted in 3 of the patients, all of whom had improvement in the frequency of the triphasic discharges, but only 2 of whom demonstrated a concurrent partial and transient improvement in mental status. All 4 patients had normalization of mental status upon discontinuation of cefepime. We provide a literature review of prior cases and propose that these reports, including those labeled as NCSE, are best described as a cefepime-induced encephalopathy with triphasic discharges as opposed to an ictal phenomenon. We contend that aggressive treatment with anti-seizure medications is not warranted and that cefepime discontinuation is the definitive treatment. This case series and review of the literature clarifies a long-standing terminological ambiguity in a unique clinical picture that can be encountered by the neurohospitalist or other providers.
Identification and Management of the Hypervirulent Invasive Klebsiella pneumoniae Syndrome: A Unique and Distinct Clinical Entity
Authors: Maheswaranathan Mithu , Ngo Tue , Rockey Don C.
Published: October 2018

In this article, we describe the case of a 61-year-old woman who presented with altered mental status and was found to have Klebsiella pneumoniae meningitis, bacteremia, and hepatic abscess. Despite intravenous antibiotic therapy and percutaneous drainage of the hepatic abscess, the patient developed worsening meningitis with ventriculitis, which led to her death. This invasive Klebsiella syndrome is characterized by metastatic infections with a hypervirulent strain and a poor clinical prognosis. Important elements of this patient’s case—including the widespread and highly aggressive course—and of those reported in the literature are reviewed. Although the invasive Klebsiella syndrome is an increasingly recognized clinical entity, most often in the Eastern hemisphere, it remains rare in the United States with approximately 20 cases reported in the literature, and given its high morbidity, it is vitally important for clinicians to recognize.
A decreased and less sustained desmopressin response in hemophilia A carriers contributes to bleeding
Authors: Candy Victoria , Whitworth Hilary , Grabell Julie , Thibeault Lisa , Harpell Lori , Bowman Mackenzie , Good David , Hopman Wilma M. , Sidonio Robert F. , James Paula D.
Published: October 2018

The cause of hemophilia A carrier bleeding is not well established. Desmopressin (DDAVP), used clinically to treat or prevent bleeding, can also be used as a medical stress surrogate. This study’s objective was to compare the response to DDAVP in hemophilia A carriers with that in normal control patients. Bleeding was assessed by the International Society on Thrombosis and Hemostasis Bleeding Assessment Tool (ISTH-BAT). DDAVP (0.3 μg/kg) was administered either IV or subcutaneously (SC), and blood was drawn at baseline and 1, 2, and 4 hours postadministration. Blood was assessed for factor VIII (FVIII) level, von Willebrand factor (VWF) antigen (VWF:Ag), VWF activity (VWF:RCo or VWF:GPIbM), thromboelastography (TEG), and thrombin generation assay (TGA) at all points, and for VWF propeptide (VWFpp):Ag ratio and ABO blood type at baseline. Carriers were older than control patients (median age, 34 and 21 years, respectively; P = .003) and had higher ISTH-BAT bleeding scores (median bleeding score, 8 and 0, respectively; P = .001). Carriers had a significantly reduced FVIII response to DDAVP compared with control patients (P ≤ .0001). When only carriers with normal baseline FVIII levels (n = 10) were included, carriers maintained a reduced FVIII response (P ≤ .0001). Furthermore, participants with abnormal bleeding scores had a significantly lower FVIII response to DDAVP compared with those with normal bleeding scores (P = .036). Hemophilia A carriers have a lower and less sustained FVIII response to DDAVP, suggesting an impaired ability to respond to hemostatic stress, which contributes to bleeding.
The role of induction chemotherapy followed by surgery in unresectable stage IVb laryngeal and hypopharyngeal cancers: A case series
Authors: Sittitrai Pichit , Reunmarkkaew Donyarat , Chaiyasate Saisaward
Published: October 2018

Background

The purpose of this study was to evaluate the benefit of induction chemotherapy followed by surgery in locally advanced unresectable stage IVb laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC).

Methods

Data of patients with stage IVb LHSCC who received induction chemotherapy for the purpose of tumor resection between January 2007 and January 2016 were retrospectively collected. Definitive surgery with postoperative adjuvant therapy was performed in patients whose tumors became resectable (resectable group). Chemoradiotherapy, radiotherapy, or supportive care was considered in patients whose tumors remained unresectable (unresectable group).

Results

Thirty-two patients were identified; the tumor resectability rate after induction chemotherapy was approximately 56%. The median overall survival (OS) rates of the resectable and unresectable groups were 20.0 months (range, 16.0–35.5 months) and 9.5 months (range, 6.0–15.0 months), respectively ( p = 0.008). The estimated 2-year OS rates of the resectable and unresectable groups were 59.5% (95% confidence interval [CI], 33.2–78.3%) and 10.7% (95% CI, 1.1–35.4%), respectively ( p = 0.008). The estimated 2-year disease-free survival (DFS) rates of the resectable and unresectable groups were 53.5% (95% CI, 27.9–73.6%), and 14.3% (95% CI, 2.3–36.6%), respectively ( p = 0.009). On multivariate analysis, factors positively impacting OS and DFS in all patients were surgical resection, a laryngeal primary site, and induction chemotherapy with docetaxel, cisplatin, and fluorouracil.

Conclusions

In advanced unresectable stage IVb LHSCC patients, surgical resection following induction chemotherapy appears to improve survival outcomes.
Multichannel impedance inversion for nonstationary seismic data based on the modified alternating direction method of multipliers
Authors: Ma Ming , Zhang Rui , Yuan Sanyi
Published: October 2018

We have upgraded the conventional nonconvex optimization algorithm and addressed a new technique to estimate the acoustic impedance (AI) for attenuated seismic data based on the modified alternating direction method of multipliers (ADMM). To eliminate the discontinuity in the inverted AI profiles with the existing single-trace processing strategy, we construct a multichannel framework and a dimensional reduction operation is used with a brief matrix manipulation in the designed forward-simulation model. The [Formula: see text] norm constraint in the inversion function can assist to search a global optimal AI solution. In the promoted ADMM solving procedure, we invoke the limited-memory Broyden-Fletcher-Goldfarb-Shanno algorithm and the generalized iterated-shrinkage algorithm to solve the relative suboptimization problems. Our new technique could recover an absolute AI from the nonstationary seismic data directly, even though this inversion problem is seriously ill-posed and nonlinear. The inverted AI profile will be satisfied with the assumption that the calculated reflectivity is comparatively sparse corresponding to its minimum [Formula: see text]-norm. Appending this adequate constraint term to the objective function is crucially significant in reducing the number of estimated AI. Due to the consideration of seismic attenuation in the equation, the inversion approach is deployed into the nonstationary reflection data avoiding the drawbacks brought by the energy-compensation processing (e.g., inverse [Formula: see text]-filtering). Using synthetic and field data, we determine the performance of our method.
Slantf-ktransform of multichannel seismic surface wave data
Authors: Serdyukov Aleksander S. , Yablokov Aleksander V. , Duchkov Anton A. , Azarov Anton A. , Baranov Valery D.
Published: October 2018

We have addressed the problem of estimating surface-wave phase velocities through the spectral processing of seismic data. This is the key step of the well-known near-surface seismic exploration method, called multichannel analysis of surface waves. To increase the accuracy and ensure the unambiguity of the selection of dispersion curves, we have developed a new version of the frequency-wavenumber ([Formula: see text]-[Formula: see text]) transform based on the S-transform. We obtain the frequency-time representation of seismic data. We analyze the obtained S-transform frequency-time representation in a slant-stacking manner but use a spatial Fourier transform instead of amplitude stacking. Finally, we build the [Formula: see text]-[Formula: see text] image by analyzing the spatial spectra for different steering values of the surface-wave group velocities. The time localization of the surface-wave packet at each frequency increases the signal-to-noise ratio because of an exclusion of noise in other time steps (which does not fall in the effective width of the corresponding wavelet). The new [Formula: see text]-[Formula: see text] transform, i.e., the slant [Formula: see text]-[Formula: see text] (SFK) transform, renders a better spectral analysis than the conventional [Formula: see text]-[Formula: see text] transform and yields more accurate phase-velocity estimation, which is critical for the surface-wave analysis. The advantages of the SFK transform have been confirmed by synthetic- and field-data processing.
Integrated geologic, geophysical, and petrophysical data to construct full field geologic model of Cambrian-Ordovician and Upper Cretaceous reservoir formations, Central Western Sirte Basin, Libya
Authors: Abdelnabi Abdalla A. , Abushalah Yousf , Liu Kelly H. , Gao Stephen S.
Published: October 2018

The Cambrian-Ordovician and Upper Cretaceous formations, which are the main oil-producing formations in the central Sirte Basin, are structurally complex. The lateral and vertical heterogeneity of the reservoir formations is not well-understood, which negatively affects the performance of the reservoirs. We constructed efficient full-field static models that incorporate the lateral and vertical variation of those reservoir formations by integrating geologic and geophysical data. We determined lithology and reservoir properties by selecting appropriate petrophysical techniques that suit the available well data and overcome issues with unreliable well-log measurements. In the process of building structural models, defining and mapping the base of the Cambrian-Ordovician Gargaf Formation was very challenging because wells did not penetrate the basal formation, and the quality of the seismic data decreases with depth. Therefore, we applied techniques of adding isochore maps of the overlying Upper Cretaceous of the Bahi and Waha Formations to map basal contact and determine the thickness of the Gargaf Formation for the first time in the area. The constructed isochore maps showed the thickness variation and the distributions of the Bahi and Waha Formations and explained the influence of Gargaf paleotopography and faults on them. The fault models combined with facies and property models suggested an interconnection among the three main reservoirs. They also indicated that the quality of the Waha reservoir enhances as the lithology varies from limestones to calcareous sandstones, whereas the quality of the Gargaf reservoir was primarily controlled by fractures. The total estimate of the original oil in place with the largest contribution of hydrocarbon volume from the Waha Formation was [Formula: see text] stock tank barrel. The created model with a fine-scale geocellular covering an area of [Formula: see text] is unique to the study area and it can be updated and refined at any time with new data production and drilling activities.
Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery—2018
Authors: Evered L. , Silbert B. , Knopman D. S. , Scott D. A. , DeKosky S. T. , Rasmussen L. S. , Oh E. S. , Crosby G. , Berger M. , Eckenhoff R. G.
Published: October 2018

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderly patients after anaesthesia and surgery, and cognitive changes have been identified up to 7.5 yr afterwards. Importantly, other studies have identified that the incidence of cognitive change is similar after non-cardiac surgery. Other than the inclusion of non-surgical control groups to calculate postoperative cognitive dysfunction, research into these cognitive changes in the perioperative period has been undertaken in isolation from cognitive studies in the general population. The aim of this work is to develop similar terminology to that used in cognitive classifications of the general population for use in investigations of cognitive changes after anaesthesia and surgery. A multispecialty working group followed a modified Delphi procedure with no prespecified number of rounds comprised of three face-to-face meetings followed by online editing of draft versions.

Two major classification guidelines [Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5) and National Institute for Aging and the Alzheimer Association (NIA-AA)] are used outside of anaesthesia and surgery, and may be useful for inclusion of biomarkers in research. For clinical purposes, it is recommended to use the DSM-5 nomenclature. The working group recommends that ‘perioperative neurocognitive disorders’ be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period. This includes cognitive decline diagnosed before operation (described as neurocognitive disorder); any form of acute event (postoperative delirium) and cognitive decline diagnosed up to 30 days after the procedure (delayed neurocognitive recovery) and up to 12 months (postoperative neurocognitive disorder).
On the importance of the Estonian constitutional typing system for sports anthropology
Authors: Raschka Christoph
Published: October 2018

In sports anthropology, two main international schools of constitutional typing are used: on the one hand the Anglo-American tradition of somato typing, but in the German-speaking world, on the other hand, the checkerboardtype constitution type system (Conrad) has dominated. A unique innovative approach to determining the individual constitutional type was achieved by Helje Kaarma: the Estonian constitutional typing system, con sisting of the 5 height-weight class system (small, medium, large, pyknomorphic and leptomorphic). In a series of follow-up studies, Kaarma and her daughter R. Stamm succeeded in establishing this system in sports anthropology. Furthermore, Papers on Anthropology is an important scientific platform for international sports anthropological research.
¿Hay pereza fiscal territorial en Colombia?
Authors: Bonet-Morón Jaime , Pérez-Valbuena Gerson Javier , Ricciulli-Marín Diana
Published: October 2018

La mayor descentralización introducida en la Constitución Política de 1991 incrementó las transferencias a las entidades territoriales colombianas para que estas financiaran los nuevos gastos que debían asumir. Usando un modelo de dobles diferencias y un panel con efectos fijos, este documento evalúa si este aumento en las transferencias ha sido una fuente de pereza fiscal en los municipios colombianos. La investigación discrimina por tipo de municipios y por los dos fondos de transferencias vigentes (sgp y sgr). Los resultados muestran que, en el agregado, no hay evidencia de que las transferencias hayan afectado de manera negativa el recaudo municipal.
Improving patient flow in an emergency department
Authors: Ameh Victor , Nasir Hamza , Ahmed Sarah , Abbasi Ayaz
Published: October 2018

Background:

The emergency department at Wrightington, Wigan and Leigh NHS Foundation Trust treats more than 90 000 patients every year. It is a sizable emergency department based in a large district general hospital. The department welcomes both adults and children and is also a designated major trauma unit. The case mix and demographics of these patients vary widely; however, a large proportion of these patients are elderly with multiple comorbidities. The smooth running of this emergency department depends on an unimpeded patient flow through the unit in a timely manner while ensuring that high quality care is provided. The ‘initial senior assessment and treatment’ model is designed to address some of the difficulties and challenges faced by the department.

Methods:

Two audits were undertaken four months apart in July and November 2015. In total, the first audit involved 200 adult patients, 100 of which were randomly allocated to the initial senior assessment and treatment and 100 to the non-initial senior assessment and treatment category. Patients were seen by a dedicated initial senior assessment and treatment team led by either an emergency department consultant, or an emergency department middle grade doctor. The parameters audited include: times to assessment, investigation, treatment and disposal. The second audit of 60 patients explored the staff perception to the process. In total, 20 were allocated to the initial senior assessment and treatment and 40 to the non-initial senior assessment and treatment.

Results:

The results of both audits showed a significant reduction in all the parameters investigated; however, there was a mixed staff perception to the process.

Conclusion:

The initial senior assessment and treatment process significantly improved the patients' journey.
How, and why, does capitation affect general dental practitioners' behaviour? A rapid realist review
Authors: Goodwin Tom Lloyd , Brocklehurst Paul , Hall Beth , McDonald Ruth , Tickle Martin , Williams Lynne
Published: October 2018

From a formal evaluation of a capitation-based NHS dental contract, as part of a National Institute of Health Research funded project (HS&DR 14/19/12), data collected from a series of qualitative interviews suggest that general dental practitioners may behave differently in ways that vary from the results of previous studies. Drawing on realist methodology, a rapid realist review was conducted, enabling a programme to be developed to explain the effect of a capitation pilot on NHS dentists working in primary care. In essence, the theory postulates that general dental practitioners are affected by a number of competing interests and incentives and that this can influence their behaviour in a variety of ways. For example, a capitation-based contract may result in some general dental practitioners focusing more on prevention, as opposed to treatment, but for others it may not. It may, in practice, disincentivise some general dental practitioners to perform certain treatments, while for others no change to their clinical practice would occur. Further research is required to fully understand the causal mechanisms associated with divergent behaviour, as well as the underlying contextual conditions through which these mechanisms are activated.
Latest developments
Authors: Smith Sue
Published: October 2018

Send your letters, news stories or latest developments to: The Editor, Child Care, St Jude's Church, Dulwich Road, Herne Hill, London, SE24 0PB email: childcare@markallengroup.com
Finding more support
Authors: Martland Rebecca
Published: October 2018

It is a term that we hear regularly, but do we know what it really means, what range of behaviours it covers, and what we should look out for in children? Part three in our series.
Understanding the world
Authors: Webb Penny
Published: October 2018

Continuing our exploration of the prime and specific areas of learning, this month we focus on the understanding the world and discuss how we can support children in our settings.
Why persistence is so important
Authors: Moylett Helen
Published: October 2018

We head to the archives to offer an extract from the Practical Pre-School Books title, Active Learning, which explores the concept of resilience and the need to keep on trying.
Building up a good vocabulary
Authors: Sargent Marianne
Published: October 2018

This is the fourth in a series of extracts from the book, Developing Early Literacy Skills Outdoors, which explores ideas for providing children with opportunities to learn outside.
MPs want penalties for schools that flout the ‘Baker Clause’
Authors: Henshaw Pete
Published: October 2018

MPs find that some schools are still not opening their doors to allow colleges to talk to their students about Apprenticeships
The components of a mentally healthy school
Authors: Sunderland Margot
Published: October 2018

What are the secrets to creating a mentally healthy school? Dr Margot Sunderland explores measures that can improve the wellbeing of both students and staff
Curriculum design and delivery: Part 6
Authors: Bromley Matt
Published: October 2018

In the penultimate part of his curriculum design series, Matt Bromley considers how we can ensure our curriculum builds on what pupils have learnt in primary, and also looks at how we should approach key stage 3
A systematic review of McKittrick–Wheelock syndrome
Authors: Orchard MR , Hooper J , Wright JA , McCarthy K
Published: October 2018

Introduction

McKittrick–Wheelock syndrome describes the condition of extreme electrolyte and fluid depletion caused by large distal colorectal tumours, usually the benign villous adenoma. Patients generally present critically unwell with severe hyponatraemia, hypokalaemia and/or acute kidney injury.

Methods

A structured literature review was undertaken to discover what is known about this condition, which is almost universally described as rare. Important features of the syndrome were identified, including common presenting symptoms, blood results, tumour location and size.

Findings

Our literature search identified 257 cases reported across all languages. The most remarkable features were the long duration of symptoms (median 24 months) and the significant electrolyte derangements (median sodium of 122mmol/l and median potassium of 2.7mmol/l at initial presentation). Five key recommendations are made to improve diagnosis, including aggressive fluid resuscitation to match rectal losses and surgical intervention on the index admission. The advantages and disadvantages of different treatment options are discussed, including minimally invasive alternatives to traditional resectional surgery.

Conclusions

McKittrick–Wheelock syndrome describes a normally benign condition that can cause patients to become critically unwell and so it behoves all clinicians to be aware of it. By publishing recommendations based on a comprehensive literature review, we aim to improve diagnosis and management of this life threatening condition.
A FILOSOFIA E O SEU ENSINO SOB O DIAPASÃO DA CRIATIVIDADE
Authors: Saldanha Victor Hugo De Oliveira
Published: October 2018

O presente artigo tem o propósito de abordar a filosofia na perspectiva de sua definição e de seu ensino, especificamente no domínio na educação básica. Aabordagem ora proposta organiza-se numa estrutura tripartite: na primeira parte, pretende-se tecer algumas considerações preambulares à questão “o que é a filosofia?” e, em seguida, traçar dois requisitos fundamentais para uma possível resposta a esta interrogação. A segunda parte apresenta a definição deleuzo-guattariana da filosofia como “a arte de criar conceitos” e assinala a centralidade do conceito e do problema na caracterização da atividade filosófica. À vista da definição deleuzo-guattariana da filosofia como uma atividade per se criativa, definição que descortina o problema do ensino criativo dessa disciplina, a terceira parte sugere como possibilidade do exercício da criatividade no ensino médio a proposta do filósofo Silvio Gallo de compreender a aula de filosofia como uma oficina de conceitos.
L’AMICIZIA SECONDO ARISTOTELE
Authors: Natali Carlo
Published: October 2018

O objetivo deste artigo é retomar e reinterpretar, à luz das mais recentes contribuições dos comentadores, os dois principais problemas no que diz respeito à concepção aristotélica de amizade: a relação entre as três espécies de amizade e a necessária inclusão da amizade como componete da vida feliz.
CAUSALIDADE MATERIAL NA FILOSOFIA DA MATEMÁTICA DE ALBERTO MAGNO
Authors: Da Silva Marco Aurélio Oliveira
Published: October 2018

No século XIII, podem-se observar várias posições divergentes quanto à compreensão da demonstração geométrica. Para Tomás de Aquino, tratar-se-ia de uma simples demonstração por causalidade formal — um silogismo no qual a definição do objeto matemático figuraria como termo médio. Roger Bacon, em contrapartida, propunha a experiência como fundamental para entender a prática matemática. Alberto Magno figura em um meio termo, admitindo tanto a demonstração por causalidade formal quanto a demonstração por causalidade material.
DESCARTES E O CETICISMO
Authors: Bittencourt Joceval Andrade
Published: October 2018

Este artigo analisa a retomada do ceticismo grego pelos pensadores modernos, em três etapas: 1o - Origem e desenvolvimento do ceticismo grego; 2o – condições históricas do século XVI e XVII que facilitaram o acolhimento, entre os principais pensadores da época, do ceticismo grego; 3o – Descartes, tendo transformado adúvida natural em dúvida metódica; tendo combatido e vencido os céticos, indica o Cogito, sua primeira verdade indubitável, como o único caminho, seguro e certo, para o progresso do conhecimento humano.
A PERGUNTA DE SPINOZA
Authors: Leite Alex
Published: October 2018

O objetivo principal deste artigo é demonstrar que a iniciação filosófica de Spinoza começa com uma pergunta a respeito do bem verdadeiro. É uma pergunta apresentada aos leitores no De Intellectus. Dois interesses animam a indagação: 1) alterar a maneira como certos bens são desejados e 2) compartilhar uma investigação a respeito do que pode ser mais desejado.
UMA LEITURA FOUCAULTIANA DA RELAÇÃO CONJUGAL DOS ANTIGOS
Authors: E Santos Ana Lúcia Dos Santos
Published: October 2018

No presente texto, pretendemos abordar a relação conjugal na ética antiga, elaborando reflexões que de início mostrem como o indivíduo antigo se portava diante da prática dos prazeres, bem como era a relação entre os casais, o escravo, o rapaz e a concubina. Para os antigos, importava a maneira como se procediam diante das práticas dos prazeres, a maneira como mantinham o domínio de si e não como constituir uma moral que delimitasse o certo e o errado. Importavam-se com a maneira de como se manter temperante, sendo capaz de ter um autocontrole sobre si mesmo e também poder governar a cidade. É nessa conjuntura que teremos subsídios para a análise da relação conjugal, a qual as mulheres deviam obediência ao homem e seu esposo, e o homem devia obediência a si mesmo, umavez que necessitava manter-se moderado para isso.
Gaston Bachelard: poetique des images mimesis, l'oeil et l'esprit, Paris, 2012
Authors: Wunenburger Jean-Jacques
Published: October 2018

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HOSPITALIDADE COMO DESCONSTRUÇÃO PELA PARUSIA SEGUNDO JACQUES DERRIDA
Authors: De Meneses Ramiro Délio Borges
Published: October 2018

A desconstrução é uma audição, uma decisão e uma recitação da Palavra. Assim, a desconstrução é “abertura da palavra”. Também poderemos asseverar que a desconstrução é uma espécie de “maiêutica”, dado que há um “parto” da Palavra. Finalmente, poderemos descrever a “desconstrução” como o acolhimento do acolhimento, bem como a hospitalidade da hospitalidade. É o “acolhimento puro”. A desconstrução é a soberania da Palavra, é o poder da Palavra e, assim, assume-se como “ouvir a palavra”. Esta audição é a “melhor parte”, tal como se verificou na hospitalidade de Betânia. Assim, a desconstrução está “por-vir”. A desconstrução é o caminho do “por-vir” da Palavra. A desconstrução é hospitalidade e a hospitalidade é desconstrução, sendo a hospitalidade uma “parusia”.
CHARLES TAYLOR E RICHARD RORTY: PERIGOS E PROMESSAS DE UMA CULTURA SECULAR
Authors: Da Cruz Hilton Leal
Published: October 2018

O artigo trata do debate travado entre Charles Taylor e Richard Rorty sobre a questão da relação entre moral e filosofia política. De modo mais específico, eu apresento o diagnóstico de Charles Taylor sobre os problemas do pensamento político contemporâneo e em seguida exploro as críticas de Richard Rorty a esse diagnóstico. No final, eu apresento a proposta rortyana sobre o tipo de abordagem que ele considera mais adequada para lidar com os impasses de ordem ética e política nas sociedades modernas. O confronto entre os dois autores oferece um interessante panorama da filosofia política contemporânea e a oportunidade de colocar uma questão que me parece central no debate metafilosófico e político contemporâneo: qual o papel da filosofia em relação ao espaço público?
WALTER BENJAMIN E THEODOR ADORNO: O ESTUPOR DA FACTICIDADE À MEIA-NOITE DO SÉCULO
Authors: Matos Olgária
Published: October 2018

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Application of Importance and Performance Matrix to Assess the Quality of Services Provided by Business Incubators
Authors: Godeiro Diego Philipe de Oliveira , Dantas Marcel Lima Ribeiro , Celestino Maxwell dos Santos , Da Silva Dmitryev Cyreneu
Published: October 2018

The purpose of this article is to demonstrate the use of importance and performance matrix in assessing the quality of services provided by incubators. It is a descriptive research and it uses a qualitative approach. The research design is a case study, based on interviews with four entrepreneurs from the same incubator. It also uses a documental analysis from the public notice selection of the incubates used by this incubator. The dimensions of the services provided by incubators (infrastructure, professional services and network) and the attributes of these dimensions were selected based on previous studies. These attributes were used in the construction of the interview script and results analysis, aided by qualitative data analysis software for researchers, called NVivo® from QSR International Pty Ltd. The coding was developed based on 146 citations from interviews. High importance was attached to the infrastructure, which was evaluated as excellent. The professional services have received less importance, but they need to be improved. Despite the importance attached to the network, no robust actions were reported by the incubator. The analysis of clusters (or groupings) resulted in a group with hardware companies and another with software companies, resulting in two importance and performance matrixes being built. These matrices suggest the improvement of incubator performance in promotional activities to internal and external network. For hardware developers, access to laboratories is added. The study contributes to investigate the quality of services offered by incubators, especially when using importance and performance matrix.
Possíveis Combinações de Gênero no Processo Sucessório em Empresas Familiares: Um Estudo Comparativo no Contexto Brasileiro
Authors: Freire de Oliveira Márcia , Costa van Herk Vasconcelos Andrea , Duarte Couto Fernandes Vivian , Ferreira Maritan Rodolfo
Published: October 2018

Este artigo tem como objetivo analisar as possíveis combinações de gênero no processo sucessório em empresas familiares das cidades de Uberlândia e Monte Carmelo, no estado de Minas Gerais, Brasil. A pesquisa foi desenvolvida no nível exploratório e utilizou abordagem metodológica qualitativa por meio de estudo comparativo de doze casos. Os dados foram coletados por intermédio de entrevistas estruturadas em profundidade e analisados pelo método de análise de conteúdo e a técnica de análise categorial, cujas categorias foram definidas a posteriori (preparação da sucessão, processo de sucessão e pós-sucessão). Os resultados evidenciam falta de planejamento na preparação da sucessão, conflitos entre irmãos que ficaram à parte do processo e mudanças na gestão após a saída do sucedido. As combinações de gênero são destacadas, principalmente, nas gestões dos sucedidos/sucedidas, onde a atuação feminina é evidenciada.
Modelización de relaciones entre magnitudes geométricas en un entorno enriquecido con TICs: actividades para la escuela secundaria, diseñadas en un grupo colaborativo
Authors: Borsani Valeria , Cedrón Mara , Cicala Rosa , Di Rico Enrique , Duarte Betina , Sessa Carmen
Published: October 2018

Presentamos aquí avances de nuestra investigación que aborda el problema didáctico de integrar las TICs en las clases de matemática de nivel secundario. En este artículo nos referiremos a la instancia del diseño de actividades para el aula en torno a la modelización de relaciones entre magnitudes geométricas. Disponer de una modelización intramatemática en un entorno de geometría dinámica para el estudio de la variación de magnitudes asociadas a la situación, nos permiten plantear, entre otras cuestiones: condiciones que contribuyen en el aula a la distinción entre una situación geométrica y su modelo dinámico; la incidencia de algunas características del funcionamiento del programa en el trabajo matemático de los estudiantes y, finalmente, la configuración del área de trabajo de un entorno de geometría dinámica como variable didáctica.
Impact of Thermal Asymmetry on Efficiency of the Heat Recovery and Ways of Restoring Symmetry in the Flow Reversal Reactors
Authors: Gosiewski Krzysztof , Pawlaczyk-Kurek Anna
Published: October 2018

The problem discussed in the paper was revealed during experimental and simulation study of the waste fuel utilization (low concentrated CH4) which in coal mines is emitted to the atmosphere as the so-called ventilation air methane (abbreviation: VAM). When an intense heat recovery would be applied to the Reverse-Flow Reactor (RFR) then the reactor becomes susceptible to creation of temperature profiles asymmetry. This may adversely affects the heat recovery efficiency. When a strong asymmetry arises, it can significantly reduce the heat recovery and the system needs immediate counteraction. Commonly used control systems do not always cope with this problem. The paper discusses various RFRs control algorithms from the point of view of the ability to reduce symmetry to the acceptable range. The impact of the loss of reactor symmetry on possible heat recovery efficiency is also briefly discussed. The work is focused on RFRs which operate with significant heat recovery in a heat exchange unit in which heat is retrieved not at the rector outlet, but by cooling the hot gas from the center part of the reactor. Issues discussed in the paper are derived from being carried out in ICE-PAS through many years of simulation research, patent examinations, but primarily from the own experiences on the research & demonstration thermal flow reversal reactor (TFRR) for VAM combustion. Computer control & data recording system process data records of the experiments enabled effectively analyze the problem of creating and preventing thermal asymmetry.
Ethanolic extract of Erythrina velutina Willd ameliorate schizophrenia-like behavior induced by ketamine in mice
Authors: Ximenes Naiara Coelho , Dos Santos Júnior Manuel Alves , Vasconcelos Germana Silva , Dias Kátia Cilene Ferreira , Jucá Mércia Marques , Silva Aline Holanda , Leal Luzia Kalyne Almeida Moreira , Viana Glauce Socorro Barros , de Sousa Francisca Cléa Florenço , Vasconcelos Silvânia Maria Mendes
Published: October 2018

Background

Schizophrenia is a chronic mental disorder, characterized by positive, negative and cognitive symptoms. In general, several plants have shown activity in diseases related to the central nervous system (e.g., Erythrina velutina (EEEV), also known as “mulungu”). For this reason, we aimed to investigate the effects of standardized ethanol extract obtained from the stem bark of EEEV on the schizophrenia-like behaviors induced by ketamine (KET) administration.

Methods

Swiss mice were treated with KET (20 mg/kg, i.p.) or saline for 14 days. In addition, from 8th to 14th days, saline, EEEV (200 or 400 mg/kg, p.o.) or olanzapine (OLAN 2 mg/kg, p.o.) were associated to the protocol. On the 14th day of treatment, schizophrenia-like symptoms were evaluated by the prepulse inhibition of the startle reflex (PPI), locomotor activity evaluated by the open field test (OFT), spatial recognition memory evaluated by the Y-maze task and social interaction test (SIT).

Results

KET has caused deficits in PPI, and it has also has caused hyperlocomotion in OFT and deficits in SIT as compared to control. EEEV in both doses used, reversed behavioral changes induced by KET, likewise results obtained with the administration of OLAN.

Conclusions

Taken together, the results demonstrate that the standard extract of EEEV was able to revert schizophrenia-like symptoms, due to the administration in repeated doses of ketamine. Thus, our findings lead to a new perspective for the use of EEEV an interesting alternative for drug discovery in schizophrenia.
Property Rights in an Entangled Political Economy
Authors: Novak Mikayla
Published: October 2018

This paper outlines key applications of property rights theory from the standpoint of ‘entangled political economy,’ which conceptualises economic and political agents interacting within society. The entangled political economy framework stresses that property rights denote relationships between societal members, and that property rights are the subject of evolutionary change. The nature and role of property rights in an entangled political economy reinforces the ‘bundle of rights’ perspective, challenging notions of property rights that emphasise the primacy of ownership. Far from necessarily imperilling the integrity of a market-based economic order, the bundle orientation inherent in entangled political economy can accommodate extensive market activities grounded in robust property right protections.
Non-Neutral Money: A Market Process Perspective
Authors: Facchini François
Published: October 2018

This article studies the impact of a credit expansion monetary policy on output and unemployment rate. In the introduction the history of the Phillips curve and its interpretation are presented to understand why New Consensus Macroeconomics argues that monetary policy is neutral in long-run i. e. has no effect on economic activity and natural unemployment rate. This New Consensus Macroeconomics supports the independence of the Central Bank, inflation-targeting and the strategy of constrained discretion model and influences strongly the monetary policy of central bank today. The second section critics these three principles of the new consensus. It opposes free-banking to central banking system, and takes the defense of deflation to critic the inflation-targeting. Then the third section deals with long-run neutrality of monetary policy. In an Austrian Business Cycle perspective, there is neutrality of monetary only if the production structure must always return exactly to its level of before the boom. It is improbable, because the monetary policy via tax inflation and artificial variation of real interest rate has a long-run effects on the conditions of financing of entrepreneurial project and in fine all the market process dynamic.
Early Modern migrants in a language contact setting: Characteristics of the Dutch Heusch correspondence (1664–1665)
Authors: van der Wal Marijke
Published: October 2018

The present article demonstrates how research on confiscated late-seventeenth-century letters allows us to gain insight into linguistic practices of second and third generations of Dutch-speaking migrants who lived in the German city of Hamburg, in a predominantly Low German region. The historical background of the preserved Heusch correspondence, spoken and written communication in merchant circles, and foreign language learning will be discussed. Apart from examining features such as epistolary formulae, ellipsis, and code switching, the question is also addressed of the degree to which interference from Low (or High) German is found. An analysis of the letters reveals both adoption of the Low German reflexive pronoun sick and a diverse pattern of using the relative particle so, which is shown to be a clear case of adopting (and maybe even extending) a supraregional German relativisation strategy.
Effect of n-3 long-chain polyunsaturated fatty acids supplementation in healthy mothers on DHA and EPA profiles in maternal and umbilical blood: a randomized controlled trial
Authors: Soldo Dragan , Mikulić-Kajić Matija , Spalldi Barišić Lara , Penava Nikolina , Orlović Martina , Soldo Neven , Kajić Martin
Published: October 2018

Background

The objective of the study was to compare the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) dietary supplementation on their concentration in total lipids (TL) and lipid fractions of maternal and umbilical vein (UV) blood. The specific objective was to analyze the impact of EPA and DHA supplementation on pregnancy outcome and neonatal birth weight.

Methods

Women were randomly single-blinded (randomized controlled trial; ISRCTN36705743) allocated to the group receiving EPA and DHA supplementation (supplemented group) or the group receiving placebo-corn oil (control group) in the time period from January 1st, 2016 until March 1st, 2017. Women in the supplemented group (n=45) took 360 mg EPA and 240 mg DHA daily while controls (n=42) were given a placebo. Maternal and UV bloods were obtained at delivery. After lipid extraction, phospholipids (PL), cholesterol esters (CE), triacylglycerols (TG) and non-esterified fatty acids were separated by thin layer chromatography and analyzed by gas chromatography.

Results

Higher DHA concentrations in TL (37.24±21.87 mg/L), PL (13.14±8.07 mg/L) and triacylglycerols (2.24±2.21 mg/L) were recorded in mothers from the supplemented group when compared to the study group (TL 21.89±14.53 mg/L; P<0.001; PL 9.33±5.70 mg/L; P=0.013; TG 0.56±0.43 mg/L; P<0.001). Higher DHA concentrations in UV samples were found in TL (11.51±7.34 mg/L), PL (5.29±3.31 mg/L) and triacylglycerols (0.62±0.46 mg/L) from the supplemented groups compared with controls (TL 7.37±3.60 mg/L; P=0.002; PL 3.52±2.19 mg/L; P=0.005; TG 0.40±0.46 mg/L; P=0.035). The ratio of AA:DHA was lower in maternal (2.43) and UV serum (4.0) of the supplemented group than in the control group (maternal 3.85 P<0.001; UV 4.91 P<0.001).

Conclusion

The study demonstrated the higher ratio of AA/DHA in the control group indicating that pregnant women on the traditional Herzegovina diet need supplementation with DHA and EPA.
Risk Analysis of Cumulative Intraday Return Curves
Authors: Kokoszka Piotr , Miao Hong , Stoev Stilian , Zheng Ben
Published: October 2018

Motivated by the risk inherent in intraday investing, we propose several ways of quantifying extremal behavior of a time series of curves. A curve can be extreme if it has shape and/or magnitude much different than the bulk of observed curves. Our approach is at the nexus of functional data analysis and extreme value theory. The risk measures we propose allow us to assess probabilities of observing extreme curves not seen in a historical record. These measures complement risk measures based on point-to-point returns, but have different interpretation and information content. Using our approach, we study how the financial crisis of 2008 impacted the extreme behavior of intraday cumulative return curves. We discover different impacts on shares in important sectors of the US economy. The information our analysis provides is in some cases different from the conclusions based on the extreme value analysis of daily closing price returns.
Must We Protect Foreign Investors?
Authors: Kniess Johannes
Published: October 2018

Investment protection clauses, and the investor-state dispute settlement (ISDS) mechanisms they enable, have become a common feature of international agreements on trade and investment. Intended to promote foreign investment, these protections may also discourage governments from regulating in the public interest. This raises challenging normative questions about the rights of investors and distributive justice. In this paper, I argue that a global investment regime that disadvantages developing countries and socially disadvantaged groups is prima facie unfair. This conclusion must be defended against the claim that investors have certain independent moral rights to have their property protected, regardless of the distributive consequences. Granting the premise that such investor rights exist, I argue that these cannot plausibly ground a general rule against public interest regulation that undermines the value of property. I conclude that even if foreign investors have rights that must be safeguarded, the current investment regime must be reformed.
Dissolution improvement of an active pharmaceutical ingredient in a polymer melt by hot melt extrusion
Authors: Restrepo-Uribe Laura , Ioannidis Nicolas , del Pilar Noriega Maria
Published: October 2018

Dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in polymeric melts plays an important role in the manufacturing of solid dispersions and solid solutions. The understanding of the dissolution is essential for selecting the processing equipment, the operating conditions, and the polymer excipients. The methodology presented in this work for ketoprofen (KTO) and polymer excipients serves as a screening process to select the best API-polymer formulation for hot melt extrusion (HME) to target a specific release profile. KTO dispersion within the polymer was characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), and dissolution tests. Thermal characterization shows that a single phase amorphous solid solution (one glass transition temperature [Tg]) was achieved under the HME processing conditions and screw configuration; and with the combination of polymer excipients, an extended release profile of KTO was accomplished, releasing 100% of KTO in 24 h.
Applied battery diagnosis
Authors: Berendes Erik , Socher Sebastian , Potthoff Ulrich
Published: October 2018

Development and design of new batteries require numerous electrical diagnostic methods; impedance spectroscopy is a prevalent one of them. Nevertheless, there occurs to be a gap from laboratory conditions to the final application point of view due to differing accuracy requirements, data availability and data quality. This chapter provides some insight into applicability of analysis methods outside the laboratory scale. The beneficial usage of the impedance spectroscopy approach will be shown for three typical fields of application, namely state of charge determination, temperature detection as well as battery degradation analysis, while several chemistries like innovative LiS or LFP were under investigation.