bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatiotemporal Variation of Summertime Urban Heat Island (UHI) and Its Correlation with Particulate Matter (PM2.5) over Metropolitan Cities in Alabama
Authors: El Afandi Gamal , Ismael Hossam
Published: October 2023

More than half of the global population lives in urban areas, which can cause the phenomenon known as Urban Heat Island (UHI). UHI is a phenomenon where urban areas experience higher temperatures compared to their rural surroundings. The occurrence of UHI in large cities is primarily due to urbanization and increased vehicular emissions. Factors such as wind speed and direction, solar flux, and the thermodynamic properties of surface materials determine the intensity of UHI. It can cause thermal air circulation, leading to high concentrations of urban air pollutants such as fine particulate matter (PM2.5). These pollutants can remain suspended in the air and cause asthma and allergies. It is essential to understand the characteristics of UHI intensity and its effect on air quality. This study aims to analyze the spatiotemporal variations of UHI and their correlation with PM2.5 concentration in three Alabama cities, namely Birmingham, Montgomery, and Mobile, during the summer seasons of 2002, 2012, and 2022. The study also compares UHI in these cities with nearby rural areas to determine the effect of urbanization by calculating the Normalized Difference Building Index (NDBI). To achieve these objectives, the Land Surface Temperature (LST), UHI intensity, and NDBI Datasets were analyzed. The results showed that PM2.5 concentrations in the cities have been decreasing annually since 2002, leading to an improvement in air quality. There was a negative linear correlation between UHI intensity and PM2.5 concentration. However, LST remained consistently high throughout the study period. The correlation between UHI intensity and NDBI was positive. The findings of this study can help us better understand the dynamics and driving mechanisms of the urban heat environment. Furthermore, they can assist urban metropolitan planners in developing more efficient mitigation strategies that reduce the negative impacts of UHI and PM2.5 concentrations on the environment.
Exploring Greek UNESCO Global Geoparks: A Systematic Review of Grey Literature on Greek Universities and Future Research Avenues for Sustainable Development
Authors: Koupatsiaris Alexandros Aristotelis , Drinia Hara
Published: October 2023

The relationship between humans and the environment in the modern world is challenging. UNESCO Global Geoparks are current holistic approaches for protecting and managing geographical areas that emphasise local communities and sustainability. This paper attempts to review the grey literature of Greek universities through their academic repositories, regarding the research field referred to as Greek UNESCO Global Geoparks from 2000 to 2022 and using the keyword “Geopark” to determine possible future research directions. Through the systematic literature review methodology, from 138 bibliographic sources, 28 were selected, which met the predefined criteria. In general, there is a growing scientific–academic interest in Geoparks, which mainly concerns the aspects of geotourism (n = 7), geology (n = 6), management (n = 4), and education (n = 4). Future research directions may focus on promoting the socio-economic and cultural aspects of Geoparks, investing in collaborative management and governance of Geoparks, facing climate change and environmental challenges in Geoparks, and enhancing Geoenvironmental Education in Geoparks. Such approaches may serve the United Nation’s Seventeen Sustainable Development Goals and cultivate cognitive and emotional bonds between local populations and the geoenvironment.
Evaluation of Shear Wave Velocity Prediction Models from Standard Penetration Test N Values Depending on Geologic Attributes: A Case Study in Busan, South Korea
Authors: Heo Giseok , Kim Jaehwi , Jeong Seokho , Kwak Dongyoup
Published: October 2023

This study evaluates the effectiveness of the previously proposed Standard Penetration Test (SPT) N and shear wave velocity (VS) models in relation to the geological attributes of the Busan region, situated in the southeastern part of the Korean peninsula. The multiple empirical N-VS models, which used datasets collected from different regions in South Korea, resulted in distinct N-VS trends across models. To validate the predictive capabilities of each model, this study gathered boring logs containing SPT N and VS measurements within the Busan region, followed by a thorough residual analysis. The Busan area encompasses a delta region to the west and erosion basins within the mountains and hills to the east. Despite the relatively confined geographical scope, we found that models developed using data from fill areas exhibit superior performance for the delta region (western Busan), while models constructed from datasets within erosion basins perform better for the erosion basin region (eastern Busan). This comparative examination supports the dependence of the N-VS model on geologic attributes and offers the valuable insight that N-VS models developed with analogous geological attributes should be employed when estimating VS from SPT N values.
Postoperative Recurrence of Crohn’s Disease–Is the Early Use of Postoperative Immunomodulators Able to Modify Prognosis?
Authors: Temido Maria José , Oliveira Rui Caetano , Silva Andrea , Fontinha Guilherme Nogueira , Lopes Sandra Maria Fernandes , Figueiredo Pedro , Portela Francisco
Published: October 2023

Introduction: Many patients with Crohn’s Disease (CD) require surgical resection during their lifetime. Nevertheless, postoperative recurrence (POR) is common. Risk factors for POR are still yet to be completely established, but some prognostic factors have already been widely recognized. Patients that undergo early postoperative immunomodulators (EPI) (azathioprine or biological therapy) seem to have a lower risk of recurrence. We aimed at assessing whether or not EPI is effective in preventing POR and at the same time validating traditional and new risk factors for POR. Methods: A single-center retrospective cohort study was performed. Review of clinical, demographic and histopathological characteristics of patients undergoing ileocolonic resection for CD between 2015 and 2020 was performed. EPI was defined as the restarting or introduction of azathioprine or biologics within 8 weeks after surgery. Presence of recurrence was defined as Rutgeerts score ≥ i2. Results: Sixty-five patients were included. The median age at diagnosis was 25 years (inter-quartile range 20–33 years). POR was present in 44.6% of patients, and the median time from surgery to recurrence was 2 years. EPI was the therapeutic option in 36 patients (55.4%). Univariate analysis identified as predictors of POR within 2 years: the behavior of the disease and not taking azathioprine or biologics prior to the surgery. Moreover, univariate analysis identified as predictors of time to POR: behavior of disease, less than 5 years between diagnosis and surgery and the absence of immunomodulatory therapy prior to the surgery. Multivariable analysis revealed that EPI, after adjusting for other predictors, was not associated with a reduction in POR. Conclusions: EPI may not have a protective effect against recurrence. The strength of prognostic factors for POR may not be modified by EPI.
Extending Shelf Life of Cabbage (Brassica oleracea cv. K-Y Cross) by Using Vacuum Precooling and Modified Atmosphere Packaging
Authors: Liu Jung-Yu , Liu Che-Wei , Chen Wei-Ling , Hsu Min-Chi , Lin Huey-Ling , Chen Chang-Lin
Published: October 2023

The cabbage cultivar ‘K-Y cross’ is the most important vegetable crop in Taiwan, but it is not easy to produce through the whole year because of the hot summer. For year-round supply, the different postharvest methods such as precooling and modified atmosphere packaging (MAP) were applied to extend the storage period. The respiration rate and ethylene production were measured in a wide range of temperatures from 1 to 30 °C, and the end of precooling temperature was recommended to be around 7 °C (3/4 precooling times). Vacuum precooling (VC) took cabbages only 30 min to decrease from around 27 °C to 7 °C, which was 19 times faster than room precooling (RC). After 3/4 precooling times, temperature distribution from surface to central parts of cabbages was shown to be more uniform by VC than that by RC. After VC, the MAP was applied to maintain the quality traits of cabbages. The passive MAP could decrease the weight loss, yellowing, and physiological disorders and maintain around 2% O2 and 4% CO2 in the 0.03 mm LDPE bags at 1 °C after 12-week storage. Therefore, the quality of cabbages could be maintained over 3 months by combing VC and passive MAP.
Distribution and Prevalence of Coxiella burnetii in Animals, Humans, and Ticks in Nigeria: A Systematic Review
Authors: Muhammad Kaka A. , Gadzama Usman N. , Onyiche ThankGod E.
Published: October 2023

‘Query’ (Q) fever is a neglected but emerging or re-emerging zoonotic disease caused by the bacterium Coxiella (C.) burnetii. Several host species are considered or speculated to be the primary reservoir hosts for human infection. In the past, several research groups in Nigeria have evaluated the prevalence of C. burnetii in various vertebrate and invertebrate hosts. Currently, there is a paucity of knowledge regarding the epidemiology of the pathogen in Nigeria with limited or no attention to control and prevention programs. Therefore, this review was undertaken to comprehend the current situation of C. burnetii infection in human, domestic and peri-domestic animals, and some tick species in Nigeria since 1960 with the aim to help identify future research priorities for the country. A comprehensive literature search was performed using the PRISMA guidelines on five scientific databases including Google Scholar, PubMed, AJOL, Science Direct, and Scopus for articles published from Nigeria dealing with the screening of blood, milk, or tick DNA for evidence of C. burnetii using any standard diagnostic approach. Of the 33 published articles subjected to full-text evaluation, more than 48% of the articles met the inclusion criteria and were thus included in this review. We observed different ranges of prevalence for C. burnetii antibodies from four vertebrate hosts including cattle (2.5–23.5%), sheep (3.8–12.0%), goats (3.1–10.9%), and humans (12.0–61.3%). Additionally, the use of molecular diagnostics revealed that the DNA of C. burnetii has been amplified in eight tick species including Hyalomma (Hy) dromedarii, Hy. truncatum, Hy. impeltatum, Hy. rufipes, Hy. impressum, Amblyomma (Am.) variegatum, Rhipicephalus (Rh.) evertsi evertsi, and Rh. annulatus. Two rodent’s species (Rattus rattus and Rattus norvegicus) in Nigeria were documented to show evidence of the bacterium with the detection of the DNA of C. burnetii in these two mammals. In conclusion, this review has provided more insight on the prevalence of C. burnetii and its associated host/vector in Nigeria. Domestic animals, peri-domestic animals, and ticks species harbor C. burnetii and could be a source of human infections. Due to the paucity of studies from southern Nigeria, we recommend that research groups with interest on vector-borne diseases need to consider more epidemiological studies in the future on C. burnetii prevalence in diverse hosts to help unravel their distribution and vector potentials in Nigeria as a whole.
Infrared Imaging of the Brain-Eyelid Thermal Tunnel: A Promising Method for Measuring Body Temperature in Afebrile Children
Authors: De Meneck Franciele , Santana Vinicius , Brioschi Gabriel Carneiro , Haddad Denise Sabbagh , Neves Eduardo Borba , Franco Maria do Carmo , Brioschi Marcos Leal
Published: October 2023

(1) Infrared thermography of the inner canthus of the eye has emerged as a promising tool for temperature screening and fever diagnosis. Its non-invasive nature lends itself well to mass screening in diverse settings such as schools, public transport, and healthcare facilities. Swift and accurate temperature assessment plays a pivotal role in the early identification of potential fever cases, facilitating timely isolation, testing, and treatment, thereby mitigating the risk of disease transmission. Nonetheless, the reliability of this approach in the pediatric population, especially when compared to conventional thermometry methods, remains unexplored. This preliminary study aimed to evaluate the concordance between the temperature of the inner canthus of the eye (Tic,eye), referred to as the brain-eyelid thermal tunnel (BTT°), with axillary and tympanic methods in afebrile children. (2) Methods: A cohort of 36 children, matched in a 1:1 ratio for gender and age, underwent comprehensive assessments encompassing anthropometric data, blood pressure evaluations, axillary (Tax) and tympanic (Tty) temperature measurements, as well as BTT° infrared thermography. (3) Results: The findings revealed a high level of concordance among the tympanic, axillary, and BTT° measurement methods. Bland–Altman plots showed that the bias was minimal, and no statistically significant differences were observed when comparing BTT° with axillary (p = 0.136) and tympanic (p = 0.268) measurements. Passing–Bablok regression scatter plots further confirmed the agreement, aligning the fitted regression line closely with the identity line for both axillary versus BTT° and tympanic (Tty) versus BTT° comparisons. (4) Conclusions: This study holds significant implications for public health, especially in the context of infectious disease outbreaks such as COVID-19. BTT° infrared thermography of the inner canthus of the eye (Tic,eye) reliably measures body temperature in afebrile children in controlled settings; nevertheless, its practical application necessitates the adaptation of biothermodynamic parameters to accommodate diverse environmental conditions.
Retroviral Replicating Vectors Mediated Prodrug Activator Gene Therapy in a Gastric Cancer Model
Authors: Fujino Hiroaki , Sonoda-Fukuda Emiko , Isoda Lisa , Kawabe Ayane , Takarada Toru , Kasahara Noriyuki , Kubo Shuji
Published: October 2023

Retroviral replicating vectors (RRVs) selectively replicate and can specifically introduce prodrug-activating genes into tumor cells, whereby subsequent prodrug administration induces the death of the infected tumor cells. We assessed the ability of two distinct RRVs generated from amphotropic murine leukemia virus (AMLV) and gibbon ape leukemia virus (GALV), which infect cells via type-III sodium-dependent phosphate transporters, PiT-2 and PiT-1, respectively, to infect human gastric cancer (GC) cells. A quantitative RT-PCR showed that all tested GC cell lines had higher expression levels of PiT-2 than PiT-1. Accordingly, AMLV, encoding a green fluorescent protein gene, infected and replicated more efficiently than GALV in most GC cell lines, whereas both RRVs had a low infection rate in human fibroblasts. RRV encoding a cytosine deaminase prodrug activator gene, which converts the prodrug 5-flucytosine (5-FC) to the active drug 5-fluorouracil, showed that AMLV promoted superior 5-FC-induced cytotoxicity compared with GALV, which correlated with the viral receptor expression level and viral spread. In MKN-74 subcutaneous xenograft models, AMLV had significant antitumor effects compared with GALV. Furthermore, in the MKN-74 recurrent tumor model in which 5-FC was discontinued, the resumption of 5-FC administration reduced the tumor volume. Thus, RRV-mediated prodrug activator gene therapy might be beneficial for treating human GC.
Alleviative Effect of Iodine Pretreatment on the Stress of Saccharina japonica (Phaeophyceae, Laminariales) Caused by Cadmium and Its Molecular Basis Revealed by Comparative Transcriptomic Analysis
Authors: Wang Xuemei , Shan Tifeng , Pang Shaojun
Published: October 2023

Iodide is accumulated by the brown alga Saccharina japonica at a high concentration and has been proven to be an inorganic antioxidant that plays an important role in oxidative metabolism. Vanadium-dependent bromoperoxidases (vBPOs) and iodoperoxidases (vIPOs), which catalyze the oxidation of iodide, are essential for iodine accumulation and metabolism. Heavy metal pollutant cadmium (Cd) from anthropogenic activities can cause damage to algae mainly by producing oxidative stress. Here, the effects of iodine pretreatment on the stress of S. japonica caused by cadmium were analyzed. The growth experiment showed that iodine pretreatment could reduce the damage of low concentration cadmium on S. japonica young thalli. At the transcriptomic level, gene ontology (GO) enrichment analysis confirmed that cadmium stress could cause a peroxidation reaction in S. japonica. However, the most significant GO term was “photosystem I” in the series with iodine pretreatment. Weighted gene co-expression network analysis (WGCNA) indicated that iodine pretreatment alleviated cadmium stress responses of S. japonica by affecting the photosynthesis process. Analysis of the differentially expressed genes (DEGs) showed that five enzymes from the vBPO family and 13 enzymes from the vIPO family might play crucial roles in this process.
Identification of Potential Mechanisms of Rk1 Combination with Rg5 in the Treatment of Type II Diabetes Mellitus by Integrating Network Pharmacology and Experimental Validation
Authors: Liu Yao , Zhang Jingjing , An Chao , Liu Chen , Zhang Qiwen , Ding Hao , Ma Saijian , Xue Wenjiao
Published: October 2023

In this study, we aimed to explore the potential targets and functional mechanisms of Rk1 combined with Rg5 (Rk1+Rg5) against type II diabetes mellitus (T2DM). Network pharmacology and molecular docking were used to predict and verify the targets and signaling pathways of Rk1+Rg5 against T2DM. The results were further confirmed by a db/db mouse model and a model using PA-induced L6 cells. According to network pharmacology, a total of 250 core targets of Rk1+Rg5 towards T2DM were identified; the insulin resistance signaling pathways were enriched by KEGG. Results of molecular docking indicated good binding affinity of Rk1 and Rg5 to Akt1. In vivo and in vitro studies further showed that Rk1+Rg5 is an inhibitor of skeletal muscle insulin resistance. The results showed that Rk1+Rg5 significantly improved the hyperglycemic state of db/db mice, alleviated dyslipidemia, and promoted skeletal muscle glucose uptake. This phenomenon was closely related to the alleviation of the insulin resistance in skeletal muscles. Finally, the combination activated the Akt signaling pathway and promoted GLUT4 translocation to the cell membrane for glucose uptake. Altogether, our findings, for the first time, demonstrate that the combination of Rk1 and Rg5 could be beneficial for anti-T2DM, possibly involving ameliorated insulin resistance.
Genetic Analysis of Novel Fertility Restoration Genes (qRf3 and qRf6) in Dongxiang Wild Rice Using GradedPool-Seq Mapping and QTL-Seq Correlation Analysis
Authors: Cai Wenshan , Li Wanlin , Duan Liuying , Chen Yaling , Zhang Fantao , Hu Biaolin , Xie Jiankun
Published: October 2023

The improvement of grain yield, quality, and resistance can be achieved through the utilization of heterosis. The combination of cytoplasmic male sterility (CMS) and fertility restoration (Rf) gene(s) greatly facilitates the commercial development of three-line hybrid rice based on heterosis. The basis for investigating the relationship between CMS and Rf genes lies in the rapid localization of wild rice fertility restoration genes. A set of the BC4F5 population derived from interspecific crosses between Xieqingzao B (XB) and the BC1F9 XB//Dongxiang wild rice (DWR)/XB line L5339 was used to detect quantitative trait loci (QTL) for fertility restoration. The population was then crossed with two male sterile lines, Zhong9A (Z9A) and DongB11A (DB11A), in order to generate a testcrossing population for investigating spikelet fertility. Based on the linkage mapping, seven QTLs were detected on chromosomes 1, 3, 5, 6, 8, and 10, explaining 2.76 to 12.46% of the phenotypic variation. Of them, two novel fertility restoration QTLs, qRf3 and qRf6, can restore fertility of the CMS-DWR line DB11A by 16.56% and 15.12%, respectively. By employing joint QTL-seq and GradedPool-Seq methods, two novel Rf QTLs for DB11A, qRf3 and qRf6, were identified at the physical locations of 10,900,001–11,700,000 bp and 28,016,785–31,247,556 bp, respectively. These findings are useful for exploring the natural variations of Rf genes in rice. Therefore, rice’s new genetic resources for the selection and breeding of rice restorer lines provide promising candidates for QTL fine localization and clarification.
Integrated Analysis of Metabolome and Transcriptome Reveals Insights for Low Phosphorus Tolerance in Wheat Seedling
Authors: Li Pengcheng , Ma Xiaole , Wang Juncheng , Yao Lirong , Li Baochun , Meng Yaxiong , Si Erjing , Yang Ke , Shang Xunwu , Zhang Xueyong , Wang Huajun
Published: October 2023

Low phosphorus (LP) stress leads to a significant reduction in wheat yield, primarily in the reduction of biomass, the number of tillers and spike grains, the delay in heading and flowering, and the inhibition of starch synthesis and grouting. However, the differences in regulatory pathway responses to low phosphorus stress among different wheat genotypes are still largely unknown. In this study, metabolome and transcriptome analyses of G28 (LP-tolerant) and L143 (LP-sensitive) wheat varieties after 72 h of normal phosphorus (CK) and LP stress were performed. A total of 181 and 163 differentially accumulated metabolites (DAMs) were detected for G28CK vs. G28LP and L143CK vs. L143LP, respectively. Notably, the expression of pilocarpine (C07474) in G28CK vs. G28LP was significantly downregulated 4.77-fold, while the expression of neochlorogenic acid (C17147) in L143CK vs. L143LP was significantly upregulated 2.34-fold. A total of 4023 differentially expressed genes (DEGs) were acquired between G28 and L143, of which 1120 DEGs were considered as the core DEGs of LP tolerance of wheat after LP treatment. The integration of metabolomics and transcriptomic data further revealed that the LP tolerance of wheat was closely related to 15 metabolites and 18 key genes in the sugar and amino acid metabolism pathway. The oxidative phosphorylation pathway was enriched to four ATPases, two cytochrome c reductase genes, and fumaric acid under LP treatment. Moreover, PHT1;1, TFs (ARFA, WRKY40, MYB4, MYB85), and IAA20 genes were related to the Pi starvation stress of wheat roots. Therefore, the differences in LP tolerance of different wheat varieties were related to energy metabolism, amino acid metabolism, phytohormones, and PHT proteins, and precisely regulated by the levels of various molecular pathways to adapt to Pi starvation stress. Taken together, this study may help to reveal the complex regulatory process of wheat adaptation to Pi starvation and provide new genetic clues for further study on improving plant Pi utilization efficiency.
Hepatic SPARC Expression Is Associated with Inflammasome Activation during the Progression of Non-Alcoholic Fatty Liver Disease in Both Mice and Morbidly Obese Patients
Authors: Onorato Agostina M. , Lameroli Mauriz Lucía , Bayo Juan , Fiore Esteban , Cantero María José , Bueloni Barbara , García Mariana , Lagües Cecilia , Martínez-Duartez Pedro , Menaldi Gabriel , Paleari Nicolas , Atorrasagasti Catalina , Mazzolini Guillermo D.
Published: October 2023

The severity of non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to steatohepatitis, and it is not yet clearly understood which patients will progress to liver fibrosis or cirrhosis. SPARC (Secreted Protein Acidic and Rich in Cysteine) has been involved in NAFLD pathogenesis in mice and humans. The aim of this study was to investigate the role of SPARC in inflammasome activation, and to evaluate the relationship between the hepatic expression of inflammasome genes and the biochemical and histological characteristics of NAFLD in obese patients. In vitro studies were conducted in a macrophage cell line and primary hepatocyte cultures to assess the effect of SPARC on inflammasome. A NAFLD model was established in SPARC knockout (SPARC−/−) and SPARC+/+ mice to explore inflammasome activation. A hepatic RNAseq database from NAFLD patients was analyzed to identify genes associated with SPARC expression. The results were validated in a prospective cohort of 59 morbidly obese patients with NAFLD undergoing bariatric surgery. Our results reveal that SPARC alone or in combination with saturated fatty acids promoted IL-1β expression in cell cultures. SPARC−/− mice had reduced hepatic inflammasome activation during the progression of NAFLD. NAFLD patients showed increased expression of SPARC, NLRP3, CASP1, and IL-1β. Gene ontology analysis revealed that genes positively correlated with SPARC are linked to inflammasome-related pathways during the progression of the disease, enabling the differentiation of patients between steatosis and steatohepatitis. In conclusion, SPARC may play a role in hepatic inflammasome activation in NAFLD.
Myocardial Fibrosis in Hypertrophic Cardiomyopathy: A Perspective from Fibroblasts
Authors: Schlittler Maja , Pramstaller Peter P. , Rossini Alessandra , De Bortoli Marzia
Published: October 2023

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and the leading cause of sudden cardiac death in young people. Mutations in genes that encode structural proteins of the cardiac sarcomere are the more frequent genetic cause of HCM. The disease is characterized by cardiomyocyte hypertrophy and myocardial fibrosis, which is defined as the excessive deposition of extracellular matrix proteins, mainly collagen I and III, in the myocardium. The development of fibrotic tissue in the heart adversely affects cardiac function. In this review, we discuss the latest evidence on how cardiac fibrosis is promoted, the role of cardiac fibroblasts, their interaction with cardiomyocytes, and their activation via the TGF-β pathway, the primary intracellular signalling pathway regulating extracellular matrix turnover. Finally, we summarize new findings on profibrotic genes as well as genetic and non-genetic factors involved in the pathophysiology of HCM.
Effect of Mistuning and Blade Passing Frequencies on a Turbine’s Integral Mode Blade Vibration Detection Using a Pulsation Probe
Authors: Ando Takashi
Published: October 2023

For engines operating using heavy fuel oil (HFO), the nozzle rings of turbocharger turbines are prone to severe degradation because of contamination with unburned fuel deposits. This contamination may lead to increased excitation of blade resonance. A previous study provides technical guidelines on how to extract the relevant information from pulsation spectra using a single probe installed away from the turbine trailing edge and some sound experimental proofs of integral mode turbine vibration detection. These theoretical discussions only allude to the effects of mistuning and interferences due to classical blade passing frequencies on sound radiation patterns emitted by integral blade vibration modes. In this study, both effects are thoroughly discussed. Combining the knowledge of theoretical study and further experimental results, the application range of this blade vibration detection method can be remarkably extended.
Sound Event Detection in Domestic Environment Using Frequency-Dynamic Convolution and Local Attention
Authors: Cheimariotis Grigorios-Aris , Mitianoudis Nikolaos
Published: October 2023

This work describes a methodology for sound event detection in domestic environments. Efficient solutions in this task can support the autonomous living of the elderly. The methodology deals with the “Challenge on Detection and Classification of Acoustic Scenes and Events (DCASE)” 2023, and more specifically with Task 4a “Sound event detection of domestic activities”. This task involves the detection of 10 common events in domestic environments in 10 s sound clips. The events may have arbitrary duration in the 10 s clip. The main components of the methodology are data augmentation on mel-spectrograms that represent the sound clips, feature extraction by passing spectrograms through a frequency-dynamic convolution network with an extra attention module in sequence with each convolution, concatenation of these features with BEATs embeddings, and use of BiGRU for sequence modeling. Also, a mean teacher model is employed for leveraging unlabeled data. This research focuses on the effect of data augmentation techniques, of the feature extraction models, and on self-supervised learning. The main contribution is the proposed feature extraction model, which uses weighted attention on frequency in each convolution, combined in sequence with a local attention module adopted by computer vision. The proposed system features promising and robust performance.
A Homomorphic Encryption Framework for Privacy-Preserving Spiking Neural Networks
Authors: Nikfam Farzad , Casaburi Raffaele , Marchisio Alberto , Martina Maurizio , Shafique Muhammad
Published: October 2023

Machine learning (ML) is widely used today, especially through deep neural networks (DNNs); however, increasing computational load and resource requirements have led to cloud-based solutions. To address this problem, a new generation of networks has emerged called spiking neural networks (SNNs), which mimic the behavior of the human brain to improve efficiency and reduce energy consumption. These networks often process large amounts of sensitive information, such as confidential data, and thus privacy issues arise. Homomorphic encryption (HE) offers a solution, allowing calculations to be performed on encrypted data without decrypting them. This research compares traditional DNNs and SNNs using the Brakerski/Fan-Vercauteren (BFV) encryption scheme. The LeNet-5 and AlexNet models, widely-used convolutional architectures, are used for both DNN and SNN models based on their respective architectures, and the networks are trained and compared using the FashionMNIST dataset. The results show that SNNs using HE achieve up to 40% higher accuracy than DNNs for low values of the plaintext modulus t, although their execution time is longer due to their time-coding nature with multiple time steps.
Cutting Dipping Application of Flupyradifurone against Cassava Whiteflies Bemisia tabaci and Impact on Its Parasitism in Cassava
Authors: Caspary Ruben , Wosula Everlyne N. , Issa Khamis A. , Amour Massoud , Legg James P.
Published: October 2023

The cassava whitefly Bemisia tabaci causes damage in cassava through the feeding and vectoring of plant viruses that cause cassava mosaic and cassava brown streak diseases. This study sought to explore the efficacy of cutting dipping in flupyradifurone for whitefly control and the impact of the mode of application on whitefly parasitism under farmer field conditions. The insecticide treatment significantly reduced adult whiteflies by 41%, nymphs by 64%, and cassava mosaic disease (CMD) incidence by 16% and increased root yield by 49%. The whitefly parasitism rate by Encarsia spp. parasitoids was 27.3 and 21.1%, while Eretmocerus spp. had 26.7 and 18.0% in control and flupyradifurone, respectively, and these differences were not significant. Electropenetrography recordings of whitefly feeding behaviour on flupyradifurone-treated plants showed significantly reduced probing activity and a delay in reaching the phloem as compared to the control. The findings from this study demonstrated that cassava cutting dipping in flupyradifurone significantly reduces whitefly numbers and cassava mosaic disease incidence, thus contributing to a significant root yield increase in cassava. Flupyradifurone applied through cutting dips does not significantly impact parasitism rates in cassava fields. Routine monitoring of parasitoids and predators in insecticide-treated versus control fields should be emphasized to determine the impact of pesticides on these beneficial non-target organisms.
Urban Pest Abundance and Public Enquiries in Zurich 1991–2022
Authors: Brimblecombe Peter , Müller Gabi , Schmidt Marcus , Tischhauser Werner , Landau Isabelle , Querner Pascal
Published: October 2023

Zurich’s Urban Pest Advisory Service (UPAS) aims to survey, control and reduce hazards posed by pests. Records submitted to the UPAS may not exactly correlate with abundance but can reveal patterns of change. These reflect changes in species, public and media perceptions and the effects of climate and COVID-19, along with the effectiveness of new pest controls. Records for Blattodea and Plodia interpunctella declined in the period 1990–2022, while Cimex lectularius and Psocoptera increased. Summer has typically revealed the largest number of insects reported and Google searches show parallel seasonal variations. The Blattodea declined five-fold over time, likely due to better pest control methods (gel baits). Aedes albopictus, though rare, was the subject of media reports and awareness campaigns, which resulted in much public interest. Vespidae are abundant and have been reported in sufficient numbers to warrant an analysis of seasonal records, suggesting that July temperatures affect numbers. COVID-19 restrictions led to more frequent reports of rodents, pigeons, Zygentoma and Stegobium paniceum. The long-term reporting to the UPAS gives a useful indication of the changing concerns about pests in Zurich.
The Evaluation of Clot Waveform Analyses for Assessing Hypercoagulability in Patients Treated with Factor VIII Concentrate
Authors: Matsumoto Takeshi , Wada Hideo , Shiraki Katsuya , Suzuki Kei , Yamashita Yoshiki , Tawara Isao , Shimpo Hideto , Shimaoka Motomu
Published: October 2023

Background: Regular prophylactic therapy has become an increasingly common treatment for severe hemophilia. Therefore, hypercoagulability—a potential risk factor of thrombosis—is a cause for concern in hemophilic patients treated with a high dose of FVIII concentrate. In clot waveform analysis (CWA)-thrombin time (TT), a small amount of thrombin activates clotting factor VIII (FVIII) instead of fibrinogen, resulting in FVIII measurements using CWA-TT with a small amount of thrombin. Methods: The coagulation ability of patients treated with FVIII concentrate or emicizumab was evaluated using activated partial thromboplastin time (APTT), TT and a small amount of tissue factor-induced FIX activation assay (sTF/FIXa) using CWA. Results: The FVIII activity based on CWA-TT was significantly greater than that based on the CWA-APTT or chromogenic assay. FVIII or FVIII-like activities based on the three assays in plasma without emicizumab were closely correlated; those in plasma with emicizumab based on CWA-TT and chromogenic assays were also closely correlated. CWA-APTT and CWA-TT showed different patterns in patients treated with FVIII concentrates compared to those treated with emicizumab. In particular, CWA-TT in patients treated with FVIII concentrate showed markedly higher peaks in platelet-rich plasma than in platelet-poor plasma. CWA-APTT showed lower coagulability in hemophilic patients treated with FVIII concentrate than in healthy volunteers, whereas CWA-sTF/FIXa did not. In contrast, CWA-TT showed hypercoagulability in hemophilic patients treated with FVIII concentrate. Conclusions: CWA-TT can be used to evaluate the thrombin bursts that cause hypercoagulability in patients treated with emicizumab. Although routine APTT evaluations demonstrated low coagulation ability in patients treated with FVIII concentrate, CWA-TT showed hypercoagulability in these patients, suggesting that the evaluation of coagulation ability may be useful when using multiple assays.
Usefulness of AI-Equipped Endoscopy for Detecting Colorectal Adenoma during Colonoscopy Screening: Confirm That Colon Neoplasm Finely Can Be Identified by AI without Overlooking Study (Confidential Study)
Authors: Mizukami Kazuhiro , Fushimi Erina , Sagami Ryota , Abe Takashi , Sato Takao , Terashi Shohei , Fukuda Masahide , Nishikiori Hidefumi , Nagai Takayuki , Kodama Masaaki , Murakami Kazunari
Published: October 2023

In the present prospective case series study, we investigated the lesion-detection ability of an AI-equipped colonoscopy as an addition to colonoscopy (CS) screening. Participants were 100 patients aged ≥20 years who had not undergone CS at the study site in the last 3 years and passed the exclusion criteria. CS procedures were conducted using conventional white light imaging and computer-aided detection (CADe). Adenoma detection rate (ADR; number of individuals with at least one adenoma detected) was compared between the conventional group and the CADe group. Of the 170 lesions identified, the ADR of the CADe group was significantly higher than the ADR of the conventional group (69% vs. 61%, p = 0.008). For the expert endoscopists, although ADR did not differ significantly, the mean number of detected adenomas per procedure (MAP) was significantly higher in the CADe group than in the conventional group (1.7 vs. 1.45, p = 0.034). For non-expert endoscopists, ADR and MAP were significantly higher in the CADe group than in the conventional group (ADR 69.5% vs. 56.6%, p = 0.016; MAP 1.66 vs. 1.11, p < 0.001). These results indicate that the CADe function in CS screening has a positive effect on adenoma detection, especially for non-experts.
Bilateral Pricing of Ride-Hailing Platforms Considering Cross-Group Network Effect and Congestion Effect
Authors: Li Jing , Huang Hongfu , Li Li , Wu Jieyu
Published: October 2023

The pricing of ride-hailing platforms (e.g., Didi Rider and Uber) is heavily and simultaneously influenced by the cross-group network effect and congestion effect. To analyze the bilateral pricing of ride-hailing platforms under the influence of these two effects, in this paper we construct a game-theoretic model under four different scenarios and analyze the equilibrium outcomes. The results show that: (1) when both passengers and drivers are sensitive to hassle costs, if the cross-group network effect on the passenger side is higher than that on the driver side, then the platform’s pricing on both sides increases with the increase in the congestion effect, otherwise the prices on both sides of the platform decrease with the increase in the congestion effect; (2) when passengers are sensitive to hassle costs and drivers are sensitive to price, if the ratio for passengers’ and drivers’ different perceptions of price and hassle cost is greater than a certain threshold, then the platform’s pricing on the passenger side increases with the increase in the congestion effect and the platform’s pricing on the driver side decreases with the increase in the congestion effect, otherwise the platform’s pricing on the passenger side decreases with the increase in the congestion effect and the platform’s pricing on the drivers’ side increases with the increase in the congestion effect; (3) when passengers are sensitive to price and drivers are sensitive to hassle costs, if the ratio for passengers’ and drivers’ different perceptions of price and hassle costs is greater than a certain threshold, then the platform’s pricing on the passenger side decreases with the increase in the congestion effect and the platform’s pricing on the drivers’ side increases with the increase in the congestion effect, otherwise the platform’s pricing on the passenger side increases with the increase of the congestion effect and the platform’s pricing on the driver side decreases with the increase in the congestion effect; (4) when both passengers and drivers are price-sensitive, if the cross-group network effect on the passengers’ side is larger than that on the drivers’ side, then the platform should decrease its pricing on both sides with the increase in the congestion effect, otherwise, if the cross-group network effect on the passengers’ side is less than that on the drivers’ side, the platform should increase its pricing on both sides with the increase in the congestion effect; (5) the platform is able to generate the highest profit in each scenario, and the results of the profit comparison between the four scenarios depends on the cross-group network effects and the congestion effects on both the passengers’ and the drivers’ sides.
Conceptualization and Survey Instrument Development for Over-the-Top Platforms’ Usability
Authors: Pekpazar Aycan , Coskun Muhammed Cagri , Altin Gumussoy Cigdem
Published: October 2023

OTT (over-the-top) streaming is a subscription-based video service model that delivers video-on-demand content, films, and series directly to end-users over the Internet, bypassing the need for traditional satellite receiver systems. The most popular OTT service providers include Netflix, Hulu, Amazon Prime, and Disney+. During the COVID-19 pandemic, the viewership rates and subscriber numbers for OTT platforms rapidly increased. Like various other products and systems, usability problems can substantially impact user satisfaction, loyalty, and the intention to continue using OTT services. Therefore, this study aimed to conceptualize the usability of OTT platforms and develop an OTT Usability Measurement Scale for the usability evaluation of OTT platforms based on the Apple tvOS Guidelines and the literature. OTT platform usability was conceptualized with nine constructs, including Accessibility and Customization, Account Management, Data Entry and Search, Branding, Privacy, Navigation, Help, Content, and Design, and the concepts were measured with a scale including 48 items. The validity of the developed scale was tested through two separate survey studies conducted with Netflix web application users. The first survey involved 650 participants. At this stage, an exploratory factor analysis was used to evaluate the scale’s measurement properties, and the developed factor structure was confirmed. In the second stage, a survey with 600 participants was conducted, and a confirmatory factor analysis was applied to validate the scale properties. Furthermore, a nomological validation of the developed scale was performed, examining the relationship between the acquired OTT factors and elements such as continued intention to use, satisfaction, and brand loyalty. As a result of the nomological validation, it was observed that the privacy and design factors significantly affected each of the three dependent variables.
Earthquake Decision-Making Tool for Humanitarian Logistics Network: An Application in Popayan, Colombia
Authors: Paz-Orozco Helmer , de Brito Junior Irineu , Chong Mario , Anacona-Mopan Yesid , Segura Dorado Jhon Alexander , Moyano Mariana
Published: October 2023

Background: This study presents a comprehensive methodology for enhancing humanitarian logistics planning and management in natural disasters, focusing on earthquakes. Methods: The innovative approach combines a deterministic mathematical model with a simulation model to address the problem from multiple perspectives, aiming to improve efficiency and equity in post-disaster supply distribution. In the deterministic modeling phase, optimal locations for humanitarian distribution centers and points in Popayan, Colombia, were identified, enabling efficient resource allocation for affected families. Subsequently, the simulation model evaluated scenarios based on real earthquakes in Colombia and Latin America, providing a comprehensive view of the logistics system’s response capacity to different disaster conditions and magnitudes. Results: The results demonstrated that the proposed methodology significantly reduced supply delivery time, achieving a 30% improvement compared to traditional humanitarian logistics approaches. Moreover, it led to a more equitable coverage of affected communities, with a 25% increase in families served in previously underserved areas. Expert validation from the Disaster Risk Management Committee of the study area confirmed the methodology’s usefulness for informed and effective decision-making in real situations. Conclusions: This integrated approach of mathematical modeling and discrete event simulation offers valuable insights to address disaster management and support decision-making in humanitarian crises.
Analysis of the Effect of the Chemical Composition of Bearing Alloys on Their Wear under Wet Friction Conditions
Authors: Madej Marcin , Leszczyńska-Madej Beata
Published: October 2023

This paper discusses the results of a study to determine the effect of the chemical composition of two tin-based bearing alloys (B89 and B83) on their tribological properties. The tribological properties were tested using a T05 block-on-ring tester under technically dry and wet friction conditions. The research includes the determination of the wear rates, loss of mass, coefficients of friction, and changes in the coefficient of friction as a function of the process and material parameters. A study of the microstructure and base properties of such alloys, which affect the tribological properties and wear, are also presented. The study showed that chemical composition has a significant effect on the tribological properties; increasing the proportion and changing the morphology of the SnSb precipitates to rhomboidal in the B83 alloy results in an increase in wear resistance represented by loss of mass. Decreasing the size and proportion of these precipitates results in a stabilization of the frictional force variation and a slight decrease in the coefficient of friction. The research showed that SnSb phase precipitation is mainly responsible for the wear resistance of the investigated bearing alloys.
The Effect of Rotary Friction Welding Conditions on the Microstructure and Mechanical Properties of Ti6Al4V Titanium Alloy Welds
Authors: Gavalec Matúš , Barenyi Igor , Krbata Michal , Kohutiar Marcel , Balos Sebastian , Pecanac Milan
Published: October 2023

The main task that the article introduces is the experimental study of how the geometry of contact surfaces affects the quality and mechanical properties of a rotary friction weld (RFW), as well as the findings of whether the RFW technology is suitable for the titanium alloy Ti6Al4V. The experiments were carried out for specimens with a diameter of 10 mm and were performed at 900 RPM. Three types of geometry were proposed for the RFW process: flat on flat, flat on 37.5° and flat on 45°. Based on these results, the best tested flat geometry was selected from the perspective of quality and economic efficiency. The welded joints were subjected to microstructural analysis, tensile testing, microhardness testing, and fractography, as well as spectral analysis of the fracture surface and EDS map analysis of oxygen. The flat geometry of the contact surface resulted in the least saturation with interstitial elements from the atmosphere. Fracturing in the RFW zone led to a brittle fracture with a certain proportion of plastic deformation. A pure ductile fracture occurred in specimens fractured in the HAZ region, where the difference in UTS values compared to specimens fractured by a brittle fracture mechanism was not significant. The average UTS value was 478 MPa.