bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants of stillbirth among reviewed perinatal deaths in Ethiopia
Authors: Tesfay Neamin , Legesse Frehiwot , Kebede Mandefro , Woldeyohannes Fitsum
Published: November 2022

Background

The global burden of stillbirth has declined over time. However, the problem is still prominent in South Asian and Sub-Saharan African countries. Ethiopia is one of the top stillbirth-reporting countries worldwide. Despite several measures taken to reduce the burden of stillbirth; the pace of decline was not as good as the post-neonatal death. Thus, this study is aimed at identifying potential factors related to stillbirth in Ethiopia based on nationally reviewed perinatal deaths

Method

The national perinatal death surveillance data were used for this study. A total of 3,814 reviewed perinatal death were included in the study. Two model families,namely generalized estimating equation, and alternating logistic regression models from marginal model family were employed to investigate the risk factors of stillbirth. The alternating logistic regression model was selected as the best fit for the final analysis.

Result

Among reviewed perinatal deaths nearly forty percent (37.4%) were stillbirths. The findings from the multivariate analysis demonstrated that the place of birth (in transit and at home), cause of death (infection, and congenital and chromosomal abnormalities), maternal health condition (women with complications of pregnancy, placenta, and cord), delay one (delay in deciding to seek care) and delay three (delay in receiving adequate care) were associated with an increased risk of having a stillbirth. On the other hand, maternal education (women with primary and above education level) and the type of health facility (women who were treated in secondary and tertiary health care) were associated with a decreased risk of having a stillbirth.

Conclusion

The study identified that both individual (place of delivery, cause of death, maternal health condition, maternal education, and delay one) and facility level (type of health facility and delay three) factors contributed to stillbirth outcome. Therefore, policies that are aimed at encouraging institutional delivery, improving health seeking behavior, and strengthening facility-level readiness should be devised to reduce the high burden of stillbirth in Ethiopia.
Prevalence and associated factors of birth injury among neonates admitted at neonatal intensive care unit (NICU) in governmental hospitals of Southwest Ethiopian people regional state, Ethiopia: A multicenteric cross-sectional study
Authors: Belay Alemayehu Sayih , Negese Ketemaw , Manaye Gizachew Ayele , Debebe Shibihon
Published: November 2022

Introduction

Neonatal birth injury is the functional or structural damage of the new-born during child birth. Fetal related factors such as macrosomia, fetal height, fetal weight, and prematurity; maternal related factors such as overly young and old maternal age, parity, poor maternal health, and pelvic anomalies contribute to neonatal birth injury. Labor and delivery related factors including prolonged labor, fetal mal-presentation and mal-position, cesarean and instrumental deliveries also predispose the neonate to birth injury. This study was conducted to assess the prevalence and associated factors of birth injury among neonates admitted to the neonatal intensive care unit (NICU) in Governmental Hospitals of Southwest Ethiopia.

Objective

To assess the prevalence and associated factors of birth injury among neonates admitted to the neonatal intensive care unit (NICU) in governmental hospitals in Southwest Ethiopia.

Method

Hospital-based cross-sectional study design was implemented at Mizan-Tepi University Teaching Hospital, Bonga Gebretsadik Shawo General Hospital, and Tepi General Hospital. A total of 1,315 neonates were included in the study using systematic random sampling techniques. Data was entered using Epi-Data version 4.2 and exported to SPSS version 21 for analysis. Logistic regression analysis was conducted to see the association between the dependent and independent variable.

Results

The prevalence of neonatal birth injury was 16.7%. Predictors such as primipara, no formal education, mothers with no antenatal care, and mothers whose occupational status were unemployed were 12.27, 2.52, 2.40, and 4.26 times more likely to develop neonatal birth injuries than their counterparts, respectively. Whereas, maternal age within the age range of 25–34 years, and neonates delivered via instrumental delivery were 6.68, and 2.81 times more likely to develop neonatal birth injury compared to those whose age was greater than 34 years and neonates delivered through Cesarean section, respectively.

Conclusion

The magnitude of birth injury in the current study was significantly high. Primiparity, mothers with no history of antenatal care follow up, uneducated women, unemployed women, mode of delivery, and maternal age between 25 and 34 years were strong predictors associated with neonatal birth injury. Therefore, comprehensive maternal health care such as antenatal care follow up and health institution delivery should be promoted and well addressed to all reproductive age women and special attention should be given particularly to pregnant women in order to mitigate problems related to childbirth.
The effect of food on the pharmacokinetics of WXFL10203614, a potential selective JAK1 inhibitor, in healthy Chinese subjects
Authors: Huang Kai , Shi Yunfei , Chu Nannan , Que Linling , Ding Ying , Qian Zhenzhong , Qin Wei , Gu Xianghong , Wang Jiakun , Zhang Zhiwei , Xu Jianguo , He Qing
Published: November 2022

Objective: This study was performed to investigate the effect of food on the pharmacokinetics (PK) of WXFL10203614 in healthy Chinese subjects.

Methods: This was a randomized, open-label, single-dose, two-treatment (fed vs fasted), two-period, two-sequence, crossover study. 14 eligible subjects were averagely randomized into 2 sequences and then received 10 mg WXFL10203614 under fasted or fed condition. In each period, the blood samples were collected from 0 h (pre-dose) and serially up to 72 h post-dose, and plasma concentrations were detected using the high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. The effect of food on the PK profile and safety of WXFL10203614 were assessed.

Results: 70 subjects were screened, and 14 subjects (10 male and 4 female) were enrolled and completed the study. Under the fasted condition, WXFL10203614 was absorbed rapidly with a Tmax of 0.98 h. The absorption rate was slower, Tmax delayed by 2.98 h, and the Cmax decreased by 16.3% when WXFL10203614 administered after the high-fat and high-calorie diet, other PK parameters were not affected. The 90% confidence intervals (CIs) for the ratio (fed/fasted) of geometric means of the Cmax, AUC0-t and AUC0-∞ were 0.73–1.01, 0.90–1.03 and 0.90–1.03, indicating that the high-fat and high-calorie diet might impact the absorption process of WXFL10203614. Although the Cmax was slightly decreased, there was no significant difference in the Cmax under fasted and fed conditions. Thus, it was not considered clinically significant owing to the small magnitude of changes in Cmax. All Treatment-emergent adverse events (TEAEs) were mild and resolved spontaneously without treatment.

Conclusion: Food had no clinically relevant effects on drug system exposure of WXFL10203614. It was well tolerated under fasted and fed conditions in healthy Chinese subjects, so WXFL10203614 could be administered orally with or without food.

Clinical Trial Registration: http://www.chinadrugtrials.org.cn/index.html, identifier CTR20191636.
Sodium Channels and Local Anesthetics—Old Friends With New Perspectives
Authors: Körner Jannis , Albani Simone , Sudha Bhagavath Eswaran Vishal , Roehl Anna B. , Rossetti Giulia , Lampert Angelika
Published: November 2022

The long history of local anesthetics (LAs) starts out in the late 19th century when the content of coca plant leaves was discovered to alleviate pain. Soon after, cocaine was established and headed off to an infamous career as a substance causing addiction. Today, LAs and related substances—in modified form—are indispensable in our clinical everyday life for pain relief during and after minor and major surgery, and dental practices. In this review, we elucidate on the interaction of modern LAs with their main target, the voltage-gated sodium channel (Navs), in the light of the recently published channel structures. Knowledge of the 3D interaction sites of the drug with the protein will allow to mechanistically substantiate the comprehensive data available on LA gating modification. In the 1970s it was suggested that LAs can enter the channel pore from the lipid phase, which was quite prospective at that time. Today we know from cryo-electron microscopy structures and mutagenesis experiments, that indeed Navs have side fenestrations facing the membrane, which are likely the entrance for LAs to induce tonic block. In this review, we will focus on the effects of LA binding on fast inactivation and use-dependent inhibition in the light of the proposed new allosteric mechanism of fast inactivation. We will elaborate on subtype and species specificity and provide insights into modelling approaches that will help identify the exact molecular binding orientation, access pathways and pharmacokinetics. With this comprehensive overview, we will provide new perspectives in the use of the drug, both clinically and as a tool for basic ion channel research.
Brain inspired optoelectronic integrated receiver chip for wireless optical communication
Authors: Xie Sheng , Zhao Yuhao , Wang Lihua , Cong Jia , Mao Xurui
Published: November 2022

Inspired by the mechanism of visual attentional selection, a wireless optical communication (WOC) Integrated receiver consisting of a vertical double junction photodetector (VDJ-PD) and an attentional selection circuit (ASC) is presented. The whole receiver is fabricated in standard CMOS technology. The VDJ-PD can realize optical signal detection and wavelength identification. The attentional selection circuit activates the competition among the two PN junctions in VDJ-PD to select the signal with significant feature in real-time while discarding non-significant signals. A higher-order signal modulation scheme is applied by the proposed receiver to obtain a high transfer rate, and all data are decoded using color features. The optical testing results show that parallel and real-time communication of the red and blue light can be achieved, and the rise time is 4.47 μs. To measure the anti-interference performance of the receiver, a water tank is used to simulate a harsh communication environment. Results indicate that the real-time and reliable communication requirements in a harsh channel condition are satisfied. When the percentage ratio between the intensity of stray light relative to the light with maximum intensity is 84%, an accurate information decoding can still be achieved. Moreover, the whole processing procedure does not require the participation of ADC, CPU and memory, consequently avoiding the von Neumann bottleneck.
A new NLR disease resistance gene Xa47 confers durable and broad-spectrum resistance to bacterial blight in rice
Authors: Lu Yuanda , Zhong Qiaofang , Xiao Suqin , Wang Bo , Ke Xue , Zhang Yun , Yin Fuyou , Zhang Dunyu , Jiang Cong , Liu Li , Li Jinlu , Yu Tengqiong , Wang Lingxian , Cheng Zaiquan , Chen Ling
Published: November 2022

Bacterial blight (BB) induced by Xanthomonas oryzae pv. oryzae (Xoo) is a devastating bacterial disease in rice. The use of disease resistance (R) genes is the most efficient method to control BB. Members of the nucleotide-binding domain and leucine-rich repeat containing protein (NLR) family have significant roles in plant defense. In this study, Xa47, a new bacterial blight R gene encoding a typical NLR, was isolated from G252 rice material, and XA47 was localized in the nucleus and cytoplasm. Among 180 rice materials tested, Xa47 was discovered in certain BB-resistant materials. Compared with the wild-type G252, the knockout mutants of Xa47 was more susceptible to Xoo. By contrast, overexpression of Xa47 in the susceptible rice material JG30 increased BB resistance. The findings indicate that Xa47 positively regulates the Xoo stress response. Consequently, Xa47 may have application potential in the genetic improvement of plant disease resistance. The molecular mechanism of Xa47 regulation merits additional examination.
Plant defense under Arctic light conditions: Can plants withstand invading pests?
Authors: Mithöfer Axel , Riemann Michael , Faehn Corine A. , Mrazova Anna , Jaakola Laura
Published: November 2022

Global warming is predicted to change the growth conditions for plants and crops in regions at high latitudes (>60° N), including the Arctic. This will be accompanied by alterations in the composition of natural plant and pest communities, as herbivorous arthropods will invade these regions as well. Interactions between previously non-overlapping species may occur and cause new challenges to herbivore attack. However, plants growing at high latitudes experience less herbivory compared to plants grown at lower latitudes. We hypothesize that this finding is due to a gradient of constitutive chemical defense towards the Northern regions. We further hypothesize that higher level of defensive compounds is mediated by higher level of the defense-related phytohormone jasmonate. Because its biosynthesis is light dependent, Arctic summer day light conditions can promote jasmonate accumulation and, hence, downstream physiological responses. A pilot study with bilberry (Vaccinium myrtillus) plants grown under different light regimes supports the hypothesis.
Beyond the reactionary sea change: Antimodern thought, American politics and political science
Authors: Magalhães Pedro T.
Published: November 2022

This article examines the migration of reactionary antimodern thought from Europe to the United States of America. It assesses the impact that the work of two antimodern thinkers, Leo Strauss and Eric Voegelin, had on two distinct domains of American thought, namely, conservative political ideology and academic political science. The paper argues that the antimodern perspective, eagerly absorbed by many intellectuals, has pushed American conservatism not only in an anti-liberal, but also in an antidemocratic direction. On the other hand, in academic political science, Strauss's and Voegelin's critiques of modernity, though certainly audible and noted, were neither taken seriously nor confronted in depth by the mainstream of the discipline. This neglect should be corrected, I contend, for contemporary political science is in need of a mature and nuanced theory of modernity that is capable of rising up to the radical challenge of the antimoderns.
A web-based psychoeducational simulation game for adults in stepfamilies (GSteps)—study protocol for a randomized controlled feasibility trial
Authors: Santos Carina Mota , Costa Maria Emília , Higginbotham Brian Jensen , Martins Mariana Veloso
Published: November 2022

Background

Stepfamilies are a prevalent family form. However, less stable than nuclear, first marriage families due to the presence of risk factors such as the absence of social norms and the presence of stepchildren. Stepfamilies have unique educational needs regarding stepparenting and co-parenting issues. The development and documentation of psychoeducational intervention strategies can facilitate dissemination of ongoing studies and promote transparency. This article describes the background, design and protocol of a randomized controlled trial (RCT) evaluating the eficacy and feasibility of a web-based Psychoeducational Simulation Game (GSteps). Behavior-modeling video training (BMT) is used to demonstrate and promote relational skills, stepparenting and co-parenting effective strategies for adults in stepfamilies. A mental health professional will be available within the GSteps platform for clarification or emotional support.

Methods/design

A RCT design is presented to evaluate the outcomes of a self-administered, interactive and web-based psychoeducational Game targeting dyadic marital adjustment and interpersonal skills as the primary outcomes and remarriage beliefs, family function and stepparenting and co-parenting attitudes as the secondary outcomes. Other outcome measures include satisfaction with GSteps, participants’ knowledge learned after the intervention and a purposive sampling method will be used to access feasibility. The minimum required sample size is 112 participants (56 per condition) randomly allocated either to an experimental group (EG), receiving GSteps intervention, or to a wait-list control group (CG). A survey is conducted electronically. Assessments take place at baseline (T0), after the intervention (T1) and 1-month follow-up (T2).

Discussion

This protocol presents a RCT aimed at evaluating the efficacy of a web-based psychoeducational intervention (GSteps) designed for improving marital, stepparenting and co-parenting skills in adults who live in stepfamilies. The use of the protocol and results of intervention studies may guide the use and refinement of web-based psychoeducational intervention for stepfamilies. Additionally, GSteps may become a tool for health professionals to enhance stepfamily functioning, stepparenting skills, and marital adjustment of remarried adults.
Study on the influence mechanism of students’ behavior of participation in industrial colleges—Analysis framework based on theory of planned behavior
Authors: Zhang Yuanbao , Shen Xiangdong , Song Jinyu , Huang Tiantian
Published: November 2022

As a new organizational form for the coordinated development of education and industry, industrial college is an important carrier for application-oriented colleges and universities to implement application-oriented talent training. Based on Theory of Planned Behavior (TPB) as a theoretical framework, this research constructs a model of the influencing factors of college students’ participating in industrial colleges from five criteria: behavioral attitudes, subjective norms, perceived behavioral control, behavioral intentions and situational factors. In this study, participants (N = 541) have completed a questionnaire to assess their behavior of participation in the industrial colleges by using the structural equation model (SEM). It turns out that perceived needs, mandatory norms, exemplary norms, and self-efficacy significantly positively affect college students’ intention to participate in industrial colleges. Behavior intention and self-efficacy significantly positively affect college students’ participation in industrial colleges. Behavior intentions act as a complete mediator between perceived needs and behavior, as well as between exemplary norms and behavior. Behavioral intentions partially mediate between mandatory norms and behavior, as well as between self-efficacy and behavior. In addition, school support plays a significant positive moderating role in college students’ intention and behavior of participating in industrial colleges. These findings not only expand the relevant literature on college students’ learning behavior, but also provide useful enlightenment for college education managers on how to stimulate college students’ endogenous motivation to participate in industrial colleges.
The relationship between social creativity and aggressive behavior among Chinese junior high school students: The moderating role of hostile attribution bias
Authors: Ren Feifei , Sun Yuanyuan , Ji Lin , Wei Xing
Published: November 2022

Recently, research has begun to pay attention to the dark side of creativity. This research attempted to explore the association between social creativity and aggressive behavior as well as the moderating role of hostile attribution bias. Data were obtained from 496 junior high school students in two cities in China using a convenience sampling technique. The results showed that different aspects of social creativity were different related to aggressive behavior. Specifically, appropriateness was negatively, and harmfulness was positively related to aggressive behavior; However, the relation between originality and aggressive behavior was not significant. In addition, hostile attribution bias moderated the relationships between appropriateness/harmfulness and aggressive behavior. Specifically, the negative relation between appropriateness and aggressive behavior as well as the positive relation between harmfulness and aggressive behavior became non-significant when hostile attribution bias was low. Implications of this study are also discussed.
A stochastic approximation expectation maximization algorithm for estimating Ramsay-curve three-parameter normal ogive model with non-normal latent trait distributions
Authors: Cui Yuzheng , Lu Jing , Zhang Jiwei , Shi Ningzhong , Liu Jia , Meng Xiangbin
Published: November 2022

In the estimation of item response models, the normality of latent traits is frequently assumed. However, this assumption may be untenable in real testing. In contrast to the conventional three-parameter normal ogive (3PNO) model, a 3PNO model incorporating Ramsay-curve item response theory (RC-IRT), denoted as the RC-3PNO model, allows for flexible latent trait distributions. We propose a stochastic approximation expectation maximization (SAEM) algorithm to estimate the RC-3PNO model with non-normal latent trait distributions. The simulation studies of this work reveal that the SAEM algorithm produces more accurate item parameters for the RC-3PNO model than those of the 3PNO model, especially when the latent density is not normal, such as in the cases of a skewed or bimodal distribution. Three model selection criteria are used to select the optimal number of knots and the degree of the B-spline functions in the RC-3PNO model. A real data set from the PISA 2018 test is used to demonstrate the application of the proposed algorithm.
Gender differential item functioning analysis in measuring computational thinking disposition among secondary school students
Authors: Sovey Saralah , Osman Kamisah , Matore Mohd Effendi Ewan Mohd
Published: November 2022

Computational thinking refers to the cognitive processes underpinning the application of computer science concepts and methodologies to the methodical approach and creation of a solution to a problem. The study aims to determine how students’ cognitive, affective, and conative dispositions in using computational thinking are influenced by a gender. This study used a survey research design with quantitative approach. Five hundred thirty-five secondary school students were sampled using probability sampling with the Computational Thinking Disposition Instrument (CTDI). WINSTEPS version 3.71.0 software was subsequently employed to assess the Gender Differential item functioning (GDIF) including reliability and validity with descriptive statistics were employed to assess students’ disposition toward practicing computational thinking. In addition to providing implications for the theory, the data give verifiable research that the CT disposition profile consists of three constructs. In addition, the demonstrated CTDI has good GDIF features, which may be employed to evaluate the efficacy of the application of CT in the Malaysian curriculum by measuring the level of CT in terms of the disposition profile of students.
Community intervention programs for sex offenders: A systematic review
Authors: Barros Sofia , Oliveira Cláudia , Araújo Eduardo , Moreira Diana , Almeida Fernando , Santos Anita
Published: November 2022

Sexual violence is a phenomenon that negatively impacts the victims' physical and psychological health and well-being. Sex offenders tend not to take responsibility for their actions, have difficulties in emotion regulation and impulse control, paraphilias or other disorders, so they are a difficult group to treat. In addition, the available psychological treatment programs tend to have inconsistent and, sometimes, undesirable results. This systematic review aimed to analyse the recidivism rates of sex offenders treated in community settings. According to the PRISMA guidelines, a systematic search in three databases, EBSCOhost, PubMed, and Web of Science, and a manual search was performed. A total of 319 empirical studies using quantitative methodologies were identified, 27 of which were selected for full-text analysis. In the end, 15 studies were included, published between 1996 and 2020. The objectives, intervention approach, instruments used, and the main results and conclusions were extracted from each study. The studies explored different types of sex offenders, such as: violent sex offenders (e.g., rapists), child abusers, and child abusers with pedophilia (and/or other paraphilias). Results showed that most of the programs had a cognitive-behavioral approach (n = 13). Overall, the interventions appear to be effective in reducing recidivism rates, and some of them led to improvements in other outcomes, such as cognitive distortions, accepting responsibility, victim awareness and empathy, emotional regulation, and offense supportive attitudes. Limitations and implications for future studies were discussed.
A qualitative study of health care access among African American older adults in a socio-demographically under-resourced region during the COVID-19 pandemic
Authors: Ingram Lucy Annang , Dye Cheryl , Boger Heather , Luo Ye , Hayes Tara
Published: November 2022

Background

In the U.S., health inequities experienced by the African American community, specifically among those ages 65 and older, have been well-documented in research literature. Alongside the findings regarding disparities in disease prevalence and management, researchers have also highlighted disparities in health care access. Despite recent evidence of health inequities experienced by African Americans during the COVID pandemic, there is little research on the lived experience of this group in this critical time, health care access challenges that may be exacerbated by the pandemic, and the community's outlook for the future in addressing health disparities.

Methods

We conducted a qualitative study of African Americans to gather their perspectives about access to health care, particularly during the COVID-19 pandemic. Study participants consisted of African Americans, ages 50–85 years, who spoke English as their primary language, who resided in one of 17 counties in South Carolina that represent a region of the State known as the corridor of economic disadvantage.

Results

Forty-seven telephone interviews were conducted. While research has shown that certain populations experienced health care access disparities during the early COVID pandemic, these disparities did not appear to be exacerbated in our sample. However, participants noted an increase in the use of telehealth, and identified challenges to using this technology. Participants made recommendations about how to address disparities in health care access in their communities.

Conclusion

Our qualitative approach was useful in obtaining perspectives about access to health care during the COVID-19 pandemic from African American older adults. Continued research with older African Americans, particularly those in under-resourced communities are warranted to further elucidate these findings.
Optimization and fabrication of programmable domains for soft magnetic robots: A review
Authors: Bacchetti Alistair , Lloyd Peter , Taccola Silvia , Fakhoury Evan , Cochran Sandy , Harris Russell A. , Valdastri Pietro , Chandler James H.
Published: November 2022

Driven by the aim of realizing functional robotic systems at the milli- and submillimetre scale for biomedical applications, the area of magnetically driven soft devices has received significant recent attention. This has resulted in a new generation of magnetically controlled soft robots with patterns of embedded, programmable domains throughout their structures. This type of programmable magnetic profiling equips magnetic soft robots with shape programmable memory and can be achieved through the distribution of discrete domains (voxels) with variable magnetic densities and magnetization directions. This approach has produced highly compliant, and often bio-inspired structures that are well suited to biomedical applications at small scales, including microfluidic transport and shape-forming surgical catheters. However, to unlock the full potential of magnetic soft robots with improved designs and control, significant challenges remain in their compositional optimization and fabrication. This review considers recent advances and challenges in the interlinked optimization and fabrication aspects of programmable domains within magnetic soft robots. Through a combination of improvements in the computational capacity of novel optimization methods with advances in the resolution, material selection and automation of existing and novel fabrication methods, significant further developments in programmable magnetic soft robots may be realized.
Thulium fiber laser in BPH surgery: Bench to bedside - a systematic review on behalf of YAU Urotechnology Working Group
Authors: Taratkin Mark , Checcucci Enrico , Androsov Alexander , Azilgareeva Camilla , Brill Boris , Morozov Andrey , Puliatti Stefano , Belenchon Ines Rivero , Kowalewski Karl-Friedrich , Rodler Severin , Rivas Juan Gomez , Cacciamani Giovanni E. , Enikeev Dmitry
Published: November 2022

Introduction

The Thulium fiber laser (TFL) is a new device that in contrast to the other solid-state YAG-based lasers takes a different approach to pulse formation allowing for two different modes: in the QCW (quasi-continuous wave) function, TFL is convenient for soft tissue surgery and in the SP (Superpulsed) mode it is highly effective in lithotripsy. Thus, unlike the other thulium lasers (Tm : YAG), TFL can be used in a wide range of surgical procedures.

Materials and Methods

We conducted a systematic search in 3 databases: Medline, Scopus and Cochrane library. All original articles (both preclinical and clinical) on TFL application in soft tissue surgery were included in data analysis.

Results

In terms of its cutting properties, QCW TFL is not inferior to the other thulium lasers, and in fact allows for decreased carbonization (due to lower heat production) compared to continuous lasers (e.g. Tm : YAG). It has been used successfully in endoscopic enucleation of the prostate (EEP) and in en bloc resection of bladder tumors (ERBT). The efficacy and safety of this laser is comparable to TURP and simple prostatectomy, but the recovery period is shorter and the learning curve is slightly superior to other endoscopic procedures. There are no significant differences between TFL and Ho : YAG in terms of efficacy and safety during EEP. Unfortunately, there are no clinical studies that analyse the efficacy and safety of SP TFL in EEP or ERBT.

Conclusion

TFL is a safe and effective tool for BPH surgery. In terms of parameters, it is in no way inferior to Tm : YAG or Ho : YAG during EEP. However, TFL surpasses these lasers in terms of usability and serviceability. These advantages are likely to render it more popular over time.
A regional classification of time spectral amplitudes in total electron content: Southeastern United States during solar cycle 24
Authors: Burkholder B. L. , Cuellar R. , Nykyri K. , Ma X. , Debchoudhury S.
Published: November 2022

To investigate the meso-scale structure (100 s of km) of the ionosphere at mid-latitudes, the spectral properties in calculated total electron content (TEC) at a cluster of GPS receivers in and around Florida are analyzed. The ionosphere does not respond exactly the same to periodic solar driving at different locations around the planet, due to the complex electrodynamic interactions of the coupled magnetosphere-ionosphere system. Therefore, at each GPS receiver in the cluster we compare spatio-temporal variations of the spectral amplitudes for diurnal, solar rotation, and seasonal oscillations. The amplitudes for these dominant oscillations are organized with respect to magnetic latitude of the receiver. A low-latitude and high-latitude station are also included to put the mid-latitude ionospheric response into a global context. The amplitudes of diurnal, seasonal, and solar rotation signals are well ordered by magnetic latitude, superposed with meso-scale deviations between stations separated by ∼100s of km. The results suggest that spatio-temporal variations of spectral amplitudes in the mid-latitude ionosphere are not dominated by a single process. This conclusion is based on our finding that at high latitude, the shape of the diurnal signal varies significantly less with solar activity compared to low- and mid-latitudes, and additionally, that the ratio of annual to semi-annual amplitudes fluctuates around 1 with time and from station-to-station only at mid-latitudes.
Comparison of Two Folded Methods of Solar Sails
Authors: Yuan Laohu , Song Rui , Wang Feng , Wei Jianzheng , Liu Jiafu
Published: November 2022

The solar sails can be deployed by jointed truss or by inflated support tube. The deployed process and final deployed state of the solar sails is closely related to the design of the deployed mechanism. Therefore, the design of the deployed mechanism is very important for this new type of spacecraft. In this paper, we study the problem of the inflatable deployment of the solar sail; we utilized MSC.Patran to build the Z-folded and the Z+ curly-folded finite element models. LS-DYNA was used to simulate the dynamic characteristics of the above two solar sails under different conditions, and the results were analyzed. The results show that in the model that adopted the Z-folded method, the deployed process is relatively stable, and the effect of deployment is good, which is more suitable for practical application.
Postnatal Growth Faltering: Growth and Height Improvement at Two Years in Children with Very Low Birth Weight between 2002–2017
Authors: González-García Lara , Mantecón-Fernández Laura , Suárez-Rodríguez Marta , Arias-Llorente Rosa , Lareu-Vidal Sonia , Ibáñez-Fernández Aleida , Caunedo-Jiménez María , González-López Clara , Fernández-Morán Eva , Fernández-Colomer Belén , Solís-Sánchez Gonzalo
Published: November 2022

The prevalence of postnatal growth faltering (PGF) in preterm infants with very low birth weight (VLBW) (<1500 g) is a universal problem. Growth improvement is expected as neonatal care is optimized. Objectives: To determine if there has been a decrease in the prevalence of PGF and an improvement in height at 2 years in appropriate for gestational age VLBW children in the last two decades. Methods: Clinical descriptive retrospective analysis of neonatal somatometry at birth and at two-year corrected age in VLBW preterm infants. Small for gestational age were excluded. Two cohorts (2002–2006, n = 112; and 2013–2017, n = 92) were compared. Results. In the second five-year period, a decrease in prevalence of PGF was observed (36.6% vs. 22.8%, p = 0.033), an increase in growth rate in the first 28 days (5.22 (4.35–6.09) g/kg/day vs. 11.38 (10.61–12.15) g/kg/day, p < 0.0001) and an increase in height standard deviation (SD) at 2 years (−1.12 (−1.35–−0.91) vs. −0.74 (−0.99–−0.49) p = 0.023). Probability of short stature at 2 years was directly related to daily weight gain in the first 28 days. Conclusions: when comparing two five-year periods in the last two decades, growth in VLBW preterm infants has improved, both during neonatal period and at two years of age.
The Developing Brain: Considering the Multifactorial Effects of Obesity, Physical Activity & Mental Wellbeing in Childhood and Adolescence
Authors: Logan Nicole E. , Ward-Ritacco Christie L.
Published: November 2022

Obesity during childhood has been associated with many important physiological and neurological health considerations. Specifically concerning are the associations between youth obesity and declines in mental health, as shown with increasing rates of adolescent depression and anxiety worldwide. The emergence of mental health disorders commonly arises during adolescent development, and approximately half the global population satisfy the criteria for at least one psychiatric disorder in their lifetime, suggesting a need for early intervention. Adolescence is critical time whereby brain structure and functions are not only negatively associated with obesity and declines in mental health, while also coinciding with significant declines in rates of physical activity among individuals in this age group. Physical activity is thus a prime candidate to address the intersection of obesity and mental health crises occurring globally. This review addresses the important considerations between physiological health (obesity, aerobic fitness, physical activity), brain health (structure and function), and mental wellbeing symptomology. Lastly, we pose a theoretical framework which asks important questions regarding the influence of physiological health on the association between brain health and the development of depression and anxiety symptoms in adolescence. Specifically, we hypothesize that obesity is a mediating risk factor on the associations between brain health and psychopathology, whereas physical activity is a mediating protective factor. We conclude with recommendations for promoting physical activity and reducing sedentary time.
Butterflies, Dwarves, and Plastic Lollypops: A Case Report on Medical Clowning in a Children’s Rehabilitation Hospital
Authors: Ofer Sigalit , Keisari Shoshi
Published: November 2022

Medical clowning has been evolving in the past three decades and now plays a significant role in the rehabilitation processes of children who have suffered injuries and undergone complex medical procedures. The current paper focuses on this topic by presenting a case study of a young girl who lost most of her functional abilities due to brain damage. During the child’s physiotherapy sessions at the rehabilitation hospital, a medical clown was brought in to work together with the physiotherapist in providing the treatment. The case study brings an in-depth perspective on the therapeutic process, as it is based on documentation of the sessions while addressing key stages in the child’s rehabilitation, alongside core concepts in drama therapy. The qualitative analysis shows how the playful space in the rehabilitation process enhanced the child’s inner motivation, provided a space for role expansion, and promoted the connection between the child and the environment. This paper demonstrates how the involvement of medical clowns can promote the rehabilitation processes of children who have suffered traumatic injuries and help them cope with functional losses.
Neurological Involvement in Children with COVID-19 and MIS-C: A Retrospective Study Conducted for More than Two Years in a Pediatric Hospital
Authors: Abbati Giulia , Attaianese Federica , Rosati Anna , Indolfi Giuseppe , Trapani Sandra
Published: November 2022

This study aimed to evaluate the type and severity of neurological involvement in children with SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) and compare these findings between the two groups. Children hospitalized with the diagnosis of COVID-19 or MIS-C at Meyer Children’s Hospital between February 2020 and June 2022 were retrospectively studied. One hundred twenty-two patients were enrolled, 95 in the COVID-19 group and 27 in the MIS-C group. In the COVID-19 group, impairment of consciousness was found in 67.4% of patients, headache in 18.9% and about 16.8% of patients experienced seizures. In this group, three patients were diagnosed with arterial ischemic stroke and one patient was diagnosed with Guillain-Barré syndrome (GBS). In the MIS-C group, about 70% of patients experienced consciousness impairment, about 20% behavioral changes, and another 20% mood deflection. Neurological symptoms and signs were highly heterogeneous and could be differentiated in COVID-19 and MIS-C. Consciousness impairment remained the most frequent manifestation in both groups, potentially underlying an encephalopathy. We also highlight the importance of considering psychiatric symptoms in children with COVID-19 and/or MIS-C. Most neurological manifestations were mild in our series; however, severe complications such as ischemic stroke and GBS are worthy of note.
The Past, Present, and Future of Kingella kingae Detection in Pediatric Osteoarthritis
Authors: Yagupsky Pablo
Published: November 2022

As a result of the increasing use of improved detection methods, Kingella kingae, a Gram-negative component of the pediatric oropharyngeal microbiota, is increasingly appreciated as the prime etiology of septic arthritis, osteomyelitis, and spondylodiscitis in children aged 6 to 48 months. The medical literature was reviewed to summarize the laboratory methods required for detecting the organism. Kingella kingae is notoriously fastidious, and seeding skeletal system samples onto solid culture media usually fails to isolate it. Inoculation of synovial fluid aspirates and bone exudates into blood culture vials enhances Kingella kingae recovery by diluting detrimental factors in the specimen. The detection of the species has been further improved by nucleic acid amplification tests, especially by using species-specific primers targeting Kingella kingae’s rtxA, groEL, and mdh genes in a real-time PCR platform. Although novel metagenomic next-generation technology performed in the patient’s plasma sample (liquid biopsy) has not yet reached its full potential, improvements in the sensitivity and specificity of the method will probably make this approach the primary means of diagnosing Kingella kingae infections in the future.
Fabrication of Sulfur-Doped Reduced Graphene Oxide Modified Glassy Carbon Electrode (S@rGO/GCE) Based Acetaminophen Sensor
Authors: Khan Mohd Quasim , Kumar Praveen , Khan Rais Ahmad , Ahmad Khursheed , Kim Haekyoung
Published: November 2022

In the past few years, the design and fabrication of highly sensitive and selective electrochemical sensors have received enormous attention from electrochemists. Acetaminophen is an important drug that is used as an antipyretic and analgesic drug throughout the world. It is important to monitor the accurate amount of acetaminophen. Herein, we have prepared sulfur-doped reduced graphene oxide (S@rGO) using simple strategies. The morphological feature of the S@rGO was characterized by using scanning electron microscopy whereas phase purity and formation of S@rGO were authenticated by X-ray diffraction. Further, the glassy carbon electrode was modified using S@rGO as an electrode modifier and employed as an acetaminophen sensor (S@rGO/GCE). This modified sensor (S@rGO/GCE) demonstrates a reasonable detection limit of 0.07 µM and a sensitivity of 0.957 µA/µMcm2.
Targeted Nanoparticles for the Binding of Injured Vascular Endothelium after Percutaneous Coronary Intervention
Authors: Mungchan Pennapa , Glab-ampai Kittirat , Chruewkamlow Nuttapol , Trakarnsanga Kongtana , Srisawat Chatchawan , Nguyen Kytai T. , Chaicumpa Wanpen , Punnakitikashem Primana
Published: November 2022

Percutaneous coronary intervention (PCI) is a common procedure for the management of coronary artery obstruction. However, it usually causes vascular wall injury leading to restenosis that limits the long-term success of the PCI endeavor. The ultimate objective of this study was to develop the targeting nanoparticles (NPs) that were destined for the injured subendothelium and attract endothelial progenitor cells (EPCs) to the damaged location for endothelium regeneration. Biodegradable poly(lactic-co-glycolic acid) (PLGA) NPs were conjugated with double targeting moieties, which are glycoprotein Ib alpha chain (GPIbα) and human single-chain antibody variable fragment (HuscFv) specific to the cluster of differentiation 34 (CD34). GPIb is a platelet receptor that interacts with the von Willebrand factor (vWF), highly deposited on the damaged subendothelial surface, while CD34 is a surface marker of EPCs. A candidate anti-CD34 HuscFv was successfully constructed using a phage display biopanning technique. The HuscFv could be purified and showed binding affinity to the CD34-positive cells. The GPIb-conjugated NPs (GPIb-NPs) could target vWF and prevent platelet adherence to vWF in vitro. Furthermore, the HuscFv-conjugated NPs (HuscFv-NPs) could capture CD34-positive cells. The bispecific NPs have high potential to locate at the damaged subendothelial surface and capture EPCs for accelerating the vessel repair.
Trichoderma versus Fusarium—Inhibition of Pathogen Growth and Mycotoxin Biosynthesis
Authors: Modrzewska Marta , Błaszczyk Lidia , Stępień Łukasz , Urbaniak Monika , Waśkiewicz Agnieszka , Yoshinari Tomoya , Bryła Marcin
Published: November 2022

This study evaluated the ability of selected strains of Trichoderma viride, T. viridescens, and T. atroviride to inhibit mycelium growth and the biosynthesis of mycotoxins deoxynivalenol (DON), nivalenol (NIV), zearalenone (ZEN), α-(α-ZOL) and β-zearalenol (β-ZOL) by selected strains of Fusarium culmorum and F. cerealis. For this purpose, an in vitro experiment was carried out on solid substrates (PDA and rice). After 5 days of co-culture, it was found that all Trichoderma strains used in the experiment significantly inhibited the growth of Fusarium mycelium. Qualitative assessment of pathogen–antagonist interactions showed that Trichoderma colonized 75% to 100% of the medium surface (depending on the species and strain of the antagonist and the pathogen) and was also able to grow over the mycelium of the pathogen and sporulate. The rate of inhibition of Fusarium mycelium growth by Trichoderma ranged from approximately 24% to 66%. When Fusarium and Trichoderma were co-cultured on rice, Trichoderma strains were found to inhibit DON biosynthesis by about 73% to 98%, NIV by about 87% to 100%, and ZEN by about 12% to 100%, depending on the pathogen and antagonist strain. A glycosylated form of DON was detected in the co-culture of F. culmorum and Trichoderma, whereas it was absent in cultures of the pathogen alone, thus suggesting that Trichoderma is able to glycosylate DON. The results also suggest that a strain of T. viride is able to convert ZEN into its hydroxylated derivative, β-ZOL.
Quality of Calcium Food Supplements: Evaluation Compared to Manufacturers’ Declarations
Authors: Puścion-Jakubik Anna , Staniaszek Gabriela , Brzozowska Patrycja , Socha Katarzyna
Published: November 2022

Calcium (Ca) is a macronutrient necessary for the proper functioning of an organism. In the case of insufficient consumption with diet, its deficiencies can be supplemented with food supplements (FS). These supplements are used, for example, as an auxiliary in the prevention of osteoporosis, allergies, hair loss or nail brittleness. The purpose of the study was to assess the compliance of Ca content with the manufacturers’ declaration. The material consisted of 108 FS. Ca content was determined by atomic absorption spectrometry (AAS). It was shown that 1.9% of the samples were characterized by a Ca content that was too low in comparison to the manufacturer’s declaration, while a content that was relatively too high was found in 54.6% of FS. The quality of FS should be monitored to ensure patient safety.