bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling Novel Therapeutic Drug Targets and Prognostic Markers of Triple Negative Breast Cancer
Authors: Balkrishna Acharya , Mittal Rashmi , Arya Vedpriya
Published: September 2021

:

Triple negative breast cancer represents multiple genomic and transcriptomic heterogeneities. Genetic and epigenetic changes emerging in TNBC help it in acquiring resistance against immunological response. Distant metastasis, lack of clinically targeted therapies and prognostic markers make it the most aggressive form of breast cancer. In this review, we showed that driver alterations in targeted genes AR, ERR, TIL, TAM, miRNA, mTOR and immunosuppressive cytokines are predominantly involved in complicating TNBC by inducing cell proliferation, invasion and metastasis, and by inhibiting apoptosis. The role of node status, cathepsin-D, Ki-67 index, CD3+TIL, BRCA1 promoter methylation value and p53 as an efficient prognostic factor have also been studied to predict the disease free and overall survival rate in TNBC patients. The present review article is an attempt to gain an insight with a new vision on the etiology of TNBC, its treatment strategies and prognostic marker to identify the outcome of standard therapies and to re-design future treatment strategies to provide maximum benefit to patients.
The Role of Mitochondrial Genes in Neurodegenerative Disorders
Authors: Kumar Rajesh , Harilal Seetha , Parambi Della Grace Thomas , Kanthlal S.K. , Rahman Md Atiar , Alexiou Athanasios , Batiha Gaber El-Saber , Mathew Bijo
Published: September 2021

:

Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial
mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence
linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable
neuropathological lesions in postmortem samples. This review describes various gene mutations
in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis,
and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial
dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains
unclear in depth.
Facile Preparation of Aryl Nitriles from Aryl Aldehydes in PEG-DME 250
Authors: Kang Solbe , Lee Jong Chan
Published: September 2021

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A facie and efficient method for one-pot transformation of aryl aldehydes to aryl nitriles using hydroxylamine hydrochloride and phosphorus tribromide in PEG-DME 250 is reported. The conversion of various aryl aldehydes to the corresponding aryl nitriles occurred smoothly in high yields under the present reaction conditions.
Enteric Nervous System in Neonatal Necrotizing Enterocolitis
Authors: Chandramowlishwaran Pavithra , Raja Shreya , Maheshwari Akhil , Srinivasan Shanthi
Published: September 2021

Background:

The pathophysiology of necrotizing enterocolitis (NEC) is not clear, but
increasing information suggests that the risk and severity of NEC may be influenced by abnormalities
in the enteric nervous system (ENS).

Objective:

The purpose of this review was to scope and examine the research related to ENS-associated
abnormalities that have either been identified in NEC or have been noted in other inflammatory
bowel disorders (IBDs) with histopathological abnormalities similar to NEC. The aim was to
summarize the research findings, identify research gaps in existing literature, and disseminate them
to key knowledge end-users to collaborate and address the same in future studies.

Methods:

Articles that met the objectives of the study were identified through an extensive literature
search in the databases PubMed, EMBASE, and Scopus.

Results:

The sources identified through the literature search revealed that: (1) ENS may be involved
in NEC development and post-NEC complications, (2) NEC development is associated
with changes in the ENS, and (3) NEC-associated changes could be modulated by the ENS.

Conclusions:

The findings from this review identify the enteric nervous as a target in the development
and progression of NEC. Thus, factors that can protect the ENS can potentially prevent and
treat NEC and post-NEC complications. This review serves to summarize the existing literature
and highlights a need for further research on the involvement of ENS in NEC.
The Acetyltransferase KAT5 Inhibitor NU 9056 Promotes Apoptosis and Inhibits JAK2/STAT3 Pathway in Extranodal NK/T Cell Lymphoma
Authors: Sang Wei , Xu Kailin , Xu Linyan , Qin Yuanyuan , Liu Mengdi , Jiao Jun , Tu Dongyun , Zhang Meng , Yan Dongmei , Song Xuguang , Sun Cai , Zhu Feng , Wang Xiangmin
Published: September 2021

Background:

Extranodal natural killer/T cell lymphoma (ENKTL) is an aggressive malignant non-
Hodgkin's lymphoma (NHL) with a poor prognosis. Therefore, novel therapeutic biomarkers and agents must be identified
for the same. KAT5 inhibitor, NU 9056, is a small molecule that can inhibit cellular proliferation; however, its role
in ENKTL has not been studied.

Objective:

The present study investigated the effect of NU 9056 in ENKTL cells and explored the possible molecular
mechanism for its antitumour effect.

Methods:

The role of NU 9056 in ENKTL cells was investigated through the Cell Counting Kit-8 assay, flow cytometry,
Western blot, and real-time quantitative polymerase chain reaction assay.

Results:

NU 9056 inhibited ENKTL cell proliferation and induced G2/M phase arrest. NU 9056 also induced apoptosis
by upregulating DR4, DR5, and caspase 8 expressions. Additionally, NU 9056 increased the expression of Bax, Bid,
and cytochrome C and decreased the expression of Bcl-2, Mcl-1, and XIAP. Furthermore, NU 9056 activated endoplasmic
reticulum (ER) stress and inhibited the JAK2/STAT3 signalling pathway. The p38 mitogen-activated protein
kinase (MAPK) signalling pathway was also activated by NU 9056, and the ERK signalling pathway was suppressed
in natural killer/T cell lymphoma cells.

Conclusion:

NU 9056 inhibited cell proliferation, arrested cell cycle in the G2/M phase, and induced apoptosis through
the stimulation of ER stress, thus inhibiting the JAK2/STAT3 signalling pathway and regulating MAPK pathways in
ENKTL cells.
Targeting Citrate Carrier (CIC) in Inflammatory Macrophages as a Novel
Metabolic Approach in COVID-19 Patients: A Perspective
Authors: Vakili Mahsa Eshkevar , Saleh Zahra , Kabelitz Dieter , Kalantar Kurosh
Published: September 2021

Coronavirus disease-19 (COVID-19) can be a fatal disease and is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV2). SARS-CoV2 is an enveloped virus that belongs
to the Beta coronavirus subfamily. After entering into the target cells, this virus replicates rapidly
and leads to cellular damage and uncontrolled pulmonary inflammation. Huge amounts of inflammatory
cytokines and chemokines are produced by infected lung cells and are associated with monocyte
recruitment and accumulation of inflammatory macrophages at the site of infection. Mitochondrial
citrate carrier (CIC) expression increases in these macrophages, which results in elevated
levels of cytosolic citrate and the production of inflammatory mediators. In this perspective article,
we discuss the role of mitochondrial CIC in the metabolism of inflammatory macrophages and we
propose that inhibition of this carrier might be a novel therapeutic approach for COVID-19 patients.
Biodecolorization and Biodegradation of Dyes: A Review
Authors: Rane Ashwini , Joshi Sanket J.
Published: September 2021

Dyes are one of the most widely used chemical substances in day-to-day life, including in different industries. Dye manufacturers, as well as users, are experiencing great difficulty in complying with stringent regulations on wastewater containing dyes and derivatives. Most of the industries still use age-old technology and machinery and thus find it difficult to cope with the change in the scenario of current stringent environmental regulations on disposable limits, which are improvised by pollution control boards. The inherent difficulties because of technical inadequacies during dyeing result in a large amount of dyestuff getting directly lost to the industrial effluents. Synthetic dyes are quite stable recalcitrant compounds. Henceforth, the release of dyes poses an ecotoxic hazard and potential danger of bioaccumulation, eventually affecting flora and fauna. Huge quantities of water consumption generate large volumes of highly contaminated effluents. Conventional treatment processes have limitations in the color removal from wastewater. Although physico-chemical techniques are practiced, it still suffers from the ‘economy-to-scale of application’ paradigm and generation of polluting and toxic byproducts, posing disposal problems. In contrast, biological processes involving microbes, plants, or their products (such as enzymes) are touted as alternate cost-effective methods for decolorization and degradation of such synthetic dyes, albeit with limited full-scale successful applications. Biodegradation of such xenobiotics has been the topic of research for over two decades, with limited success because of the production of toxic secondary metabolites and byproducts. This review paper is an effort towards discussing the importance of biodecolorization and biodegradation of dyes, with emphasis on some recent updates such as immobilization techniques andin-silicomodelling methods and future possibilities.
Monoclonal Antibodies for Immunohistochemical Diagnosis of Breast Cancer
Authors: Turgimbayeva Aigerim , Issabekova Assel , Zhylkibayev Assylbek , Eskendirova Saule
Published: September 2021

Breast cancer is a leading malignant disease in women worldwide, although its pathology is visually localised. Currently, it has been proven that the parameters of molecular genetic biomarkers, including oncoprotein HER2, proliferation markers Ki-67, oestrogen receptors ER, and progesterone receptors PgR, are associated with breast carcinogenesis and are a reflection of the biological aggression of the tumour. The significance of these biomarkers in signalling pathways and genetic mechanisms of carcinogenesis has been described, as well as the relationship between the expression levels of each biomarker and the tumour response to appropriate therapy.

The primary antibody that imparts specificity to IHC is based on the monoclonal antibodies (mAbs) as the main immunoreagent that enables reliable identification of breast cancer cells. The most commonly used antibodies to molecular biomarkers for IHC were determined in accordance with indicators of laboratory use and efficiency (pass rate) of HER2, Ki-67, ER, PgR assessments in the NordiQC breast cancer module. The discovery of the complete structure of these biomarkers and the design of their domains and subdomains by genetic engineering methods enable the synthesis of effective monoclonal antibodies. Quantitative indicators of the expression levels of tumour biomarkers of breast cancer were determined using mAb, depending on epitope specificity and affinity.
Green Synthesis of Metal and Metal-oxide Nanoparticles Pertinent to
Catharanthus roseus and Moringa oleifera - A Review
Authors: Riazunnisa Khateef , Syeda Anjum Mobeen , Khadri Habeeb
Published: September 2021

Background:

Biological synthesis via greener routes attained eclectic interest for research
investigators due to its reliable, sustainable, eco-friendly, and non-toxic nature since numerous
efforts have been made laterally with reflective applications by synthesizing diverse nanomaterials,
including metals/metal oxides, hybrid, and bioinspired materials during the past era.

Objective:

The present review aims to report, update and uncover all the minutiae concerning two
medicinal plant sources allied with diversified metal and non-metal nanoparticle synthesis through
a greener approach.

Methods:

The ornamental, medicinal plants such as Catharanthus roseus and Moringa oleifera
have been broadly studied for the synthesis of varied nanoparticles because of their innumerable secondary
metabolites, which may act as bio-reducing and stabilizing agents synthesized by metallic/
metal oxides, and non-metallic precursors such as silver, gold, sulphur, copper oxide, iron
oxide, ruthenium oxide nanoparticles by means of either leaf infusions or part/whole plant.

Conclusion:

This report highlights a phenomenon of exploiting different parts of these two plants
with their widespread applications in varied scientific domains, which may act as a promising drug
candidate for drug delivery mechanisms by means of a nano approach.
Neural Network with Particle Swarm Optimisation for Analysing Band Structure of Elastic Metamaterials
Authors: Chen Weiqi , Lee Cheuk Yu , Jia Xiuping , Qin Qing-Hua
Published: September 2021

Background:

The development of computing resources has seen machine learning techniques
and models integrated with evolutionary algorithms being successfully applied to solve a
vast of engineering problems. And the advance in elastic metamaterial research, the identification
of band structure, which reflects the physical property of Elastic Metamaterial, holds the key to the
design of wave-controlled devices.

Objective:

In order to conduct bandgap analysis on two specific metamaterial structures, machine
learning models that are integrated with the evolutionary algorithm are proposed to predict band
structure.

Methods:

This paper proposes two integration models with a new loss function for predicting elastic
metamaterial’s band structure. The self-defined loss function composed of mean square error
and concordance correlation is designed to ensure the numerical eigenfrequency values but also the
position of each band.

Results:

The results of the integration models indicate the MLPs-PSO and RBFs-PSO models indeed
have relatively satisfying performances on such pattern recognition tasks with respect to the
numerical values of the error measurements. The performances of the machine learning models
could be outstandingly improved by the Particle Swarm Optimisation algorithm.

Conclusion:

In short, the well-trained machine models are able to predict the band structure and
therefore contribute to bandgap enlargement study.
The Evaluation of Safety Property and Apoptotic Efficacy of α-L-Guluronic
Acid (G2013), as a Novel NSAID, Under In Vitro Examination on L929
and Hepatocellular Carcinoma Cell Lines
Authors: Hassani Shahrzad , Afshari Jalil Tavakol , Jafarnezhad-Ansariha Fahimeh , Mirshafiey Abbas
Published: September 2021

Background:

Many investigations have expanded this concept that liver chronic inflammation
has an essential role in persistent cell damages along with altering the liver microenvironment
leading to fibrosis, cirrhosis, and finally, hepatocellular carcinoma (HCC). To reduce inflammation
and relieve symptoms, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are commonly
used; however, their long-term usage can lead to severe adverse events on vital organs like the liver.
Interestingly, the α-L-Guluronic Acid (G2013), as a novel NSAID with immunomodulatory
properties, has shown the inhibitory effects on inflammation and metastasis in experimental models.

Objective:

This study was conducted to determine the effects of G2013 on cytotoxicity and induction
of apoptosis, as a new therapeutic target for cancer therapy, in the HepG2 cell line and the
mouse fibroblast cell line L929, as a control.

Methods:

MTT assay and flow cytometry method were carried out using the different concentrations
of G2013 (5, 15, 25, 50, 100, 200 and 400 μg/ml) in 3 distinct incubation times.

Results:

Our data showed that treatment of HepG2 cells with high concentration (400μg/mL) of
G2013 could effectively cause a decrease in cell viability, so that they were statistically different after
72 hours compared to other concentrations (5 to 200 μg/ml) (p<0.05 and p<0.01, respectively).
Moreover, the proportion of apoptosis of HepG2 cells at the dose of 200μg/mL considerably increased,
suggesting that the induction of apoptosis by G2013 in HepG2 cells is dose- and time-dependent,
which could promote its anticancer properties.

Conclusion:

The present study revealed that G2013 could induce apoptosis in the liver cancer model.
Therefore, based on these findings, G2013 might be considered as a therapeutic option in cancer
therapy.
Using an Individual-Centered Approach to Gain Insights From Wearable Data in the Quantified Flu Platform: Netnography Study (Preprint)
Authors: Greshake Tzovaras Bastian , Senabre Hidalgo Enric , Alexiou Karolina , Baldy Lukaz , Morane Basile , Bussod Ilona , Fribourg Melvin , Wac Katarzyna , Wolf Gary , Ball Mad
Published: September 2021

BACKGROUND

Wearables have been used widely for monitoring health in general, and recent research results show that they can be used to predict infections based on physiological symptoms. To date, evidence has been generated in large, population-based settings. In contrast, the Quantified Self and Personal Science communities are composed of people who are interested in learning about themselves individually by using their own data, which are often gathered via wearable devices.

OBJECTIVE

This study aims to explore how a cocreation process involving a heterogeneous community of personal science practitioners can develop a collective self-tracking system for monitoring symptoms of infection alongside wearable sensor data.

METHODS

We engaged in a cocreation and design process with an existing community of personal science practitioners to jointly develop a working prototype of a web-based tool for symptom tracking. In addition to the iterative creation of the prototype (started on March 16, 2020), we performed a netnographic analysis to investigate the process of how this prototype was created in a decentralized and iterative fashion.

RESULTS

The Quantified Flu prototype allowed users to perform daily symptom reporting and was capable of presenting symptom reports on a timeline together with resting heart rates, body temperature data, and respiratory rates measured by wearable devices. We observed a high level of engagement; over half of the users (52/92, 56%) who engaged in symptom tracking became regular users and reported over 3 months of data each. Furthermore, our netnographic analysis highlighted how the current Quantified Flu prototype was a result of an iterative and continuous cocreation process in which new prototype releases sparked further discussions of features and vice versa.

CONCLUSIONS

As shown by the high level of user engagement and iterative development process, an open cocreation process can be successfully used to develop a tool that is tailored to individual needs, thereby decreasing dropout rates.

CLINICALTRIAL
Correction: Combined Use of Web-Based and In-Person Education on Ill Health Self-management Skills in Adults With Bipolar Disorder: Protocol for a Mixed Methods Study (Preprint)
Authors: Hatzioannou Anna , Chatzittofis Andreas , Koutroubas Virginia Sunday , Papastavrou Evridiki , Karanikola Maria
Published: September 2021

UNSTRUCTURED

In “Combined Use of Web-Based and In-Person Education on Ill Health Self-management Skills in Adults With Bipolar Disorder: Protocol for a Mixed Methods Study”, (JMIR Res Protoc 2021;10(9):e25168,ndoi: 10.2196/25168), one error was noted. The last name of one author, Chatzittofis A, is by mistake written Hatzittofis in the published version. All other information regarding the author were correct.
PRIMARY BONE GRAFTING AND K-WIRE FIXATION: A PREFERABLE OPTION TO TREAT ACUTE UNSTABLE SCAPHOID FRACTURE
Authors: THAKUR SK  , CHOUDHARY SK  , JOSEPH J B MAL  , HIREMATH RN
Published: September 2021

Objective: The Objective of this study is to analyze the radiological, clinical and functional outcome of patients with acute unstable scaphoid fracture treated with primary bone grafting and K (Kirschner)-wire fixation
Methods:Based on inclusion and exclusion criteria , a prospective observational study was carried out on 21 patients with acute unstable  scaphoid fracture who had been treated with primary bone grafting and K-wire fixation from November 2017 to March 2020 and were followed up for a minimum of 24 weeks. The average patient age was 26.9 years. The time from injury to treatment averaged 11days. Surgery was done under Bier’s Block using volar approach. Bone graft was harvested from distal Radius. The mean operating time was 24 minutes.Clinical parameters like tenderness, grip strength and Range of Movement (ROM) at wrist was assessed. The functional outcome was evaluated using Modified Mayo wrist score. Bone union was assessed using serial plain radiographs.
Results:Union was achieved in all (100%) at 12 weeks. There was no evidence of Avascular necrosis (AVN) or arthrosis at latest follow up. As per Modified Mayo wrist score, there were 15 excellent,03 good and 03 fair results at the final follow-up. Individuals resumed their routine work at 12 weeks and all were comfortable with heavy works/ sports activity by 24 weeks.
Conclusion: Primary bone grafting has a definite role in the management of acute unstable scaphoid fracture by which aquicker and higher rate of union isachieved with minimal complications. Open reduction allows thorough assessment of fracture for better anatomic reduction. Although the type of fixation device hardly contributes for quicker and higher union, but then the use of K-wire for fixation is the only viable option for smaller bony fragments and is more forgiving in terms of its positioning. It has an added advantage in terms of requirement of minimal inventory and thus is a cost-effective modality. This procedure also confirms that the patients could get back to their work earlier hence decreasing economic burden.
A STUDY OF VENTILATOR-ASSOCIATED PNEUMONIA, SURGICAL SITE INFECTION AND CENTRAL LINE-ASSOCIATED BLOODSTREAM INFECTION: INCIDENCE, OUTCOME, RISK FACTORS AND MEASURES TO BE TAKEN FOR PREVENTION IN A TERTIARY CARE TEACHING HOSPITAL
Authors: MARION MABLE , MATHIAS LAIGY MARIAM , LALU LEEMOL , S ARJUN AKHILA
Published: September 2021

Objective: Hospital-associated infections (HAIs) contribute to increased morbidity and mortality, excess healthcare cost, and prolonged hospital stay. This study aims to determine the incidence, risk factors of ventilator associated pneumonia (VAP), surgical site infection (SSI), and central line associated blood stream infection (CLABSI). Together it also assesses the knowledge and practice of nursing staff, physician in understanding HAIs and prevention, also to improve the core knowledge of administration procedures.
Methods: A prospective study was conducted among patients, nurses, and doctors of Shamanur Shivashankarapa Institute of Medical Sciences and Research Center hospital for a period of about 6 months. The data were collected, analyzed in terms of both inferential and descriptive statistics.
Results: The incidence rate of VAP was found to be 23.61%. VAP was more prominent in males and occurred more in patients who received prolonged ventilation, supine position, and altered mental status, and these risk factors was found to be statistically significant (p<0.05). Acinetobacter was the commonly found causative organism for VAP. The mortality rate in our study was found to be 1 and was reported in early-onset VAP. SSI was more common in females and occurred mostly in elective surgeries with more comorbid conditions and American Society of Anesthesiologists score and these were found to be statistically significant (p<0.05). MRCONS and Escherichia coli were the most common pathogen identified. Mortality rate in our study was zero and 15 patients were clinically well. The incidence rate of CLABSI was found to be 31.25%. Out of 32 centralized patients, only 10 developed CLABSI and is more prominent in males. Staphylococcus aureus was the common organism followed by E. coli. Mortality rate in our study was zero and all the patients became clinically well. From the questionnaire survey, all the doctors and nurses were aware of HAIs and the most common susceptible population according to them were inpatients and the most effective method to prevent HAIs is to wash hand properly, use gloves while doing procedures.
Conclusion: VAP was more prominent followed by SSI and CLABSI. Study clearly indicates that educational interventions should be implemented to address the gaps regarding knowledge and practice of nurse and physicians.
REVIEW OF REGULATIONS GOVERNING SWITCHING DRUGS FROM RX TO OVER-THE-COUNTER IN THE USA, INDIA, AND EU
Authors: G MEGHANA , SWETHA K SREE GREESHMA , REDDY J RAVI KUMAR , RAJU K VENKATESWARA
Published: September 2021

Rx to over-the-counter (OTC) switch is a data-driven, scientifically rigorous, and highly regulated process that allows consumers to have OTC access to a growing range of medicines. Patients often approach a pharmacist instead of a Healthcare Professional for minor illnesses such as fever, aches, nausea, allergies, cough, and cold. Switches are a logical extension for life-cycle management of a product to defense originator company from Generic competitors. The driving factors required for switching are self-diagnosis, self-medication, and self-administration. On increasing of Rx to OTC switching relatively rules and regulations governing are also improving. Label instructions have to be simple and easily understandable by ordinary people by preventing medication errors and drug abuse. Labeling must include indications, warnings, and directions for use especially since they are administered without medical guidance. Adding a graphic description on the label may be useful to patients, mostly illiterate individuals (e.g., Drug Facts Labeling). The advertisement may also influence patients’ decisions on the selection of OTC products. Medicine advertisements should be closely monitored to ensure that they are truthful and are not misleading or unfair. In this respect, it is recommended that advertisements reflect the information that is contained in the product information leaflet, which, in turn, should be unbiased, evidence-based, and presented in a clear, understandable, and easily readable way. This article elaborates on regulatory requirements, challenges, and marketing aspects of Rx to OTC Switching medicinal products.
El carácter varonil (y otras cualidades afines) de la lengua de Castilla: fundamentos fonéticos de un tópico antiguo
Authors: Dalle Pezze Francesca , Miotti Renzo
Published: September 2021

El tópico áureo del carácter varonil del castellano tiene antigua tradición en España, ya que se remonta aun a la contraposición entre el latín de Roma y el de Hispania: observaciones en las que se aúnan los conceptos de marcialidad y varonilidad —pero también otros rasgos distintivos, estrechamente relacionados— constituyen una cadena que se extiende a lo largo de la historia de las ideas lingüísticas. Nuestro propósito es proponer algunas reflexiones, a partir de testimonios antiguos, sobre la que se denominaría, en términos sociolingüísticos, actitud afectiva —que se manifiesta a través de una adjetivación recurrente—, para después comparar dichas reflexiones con las modernas descripciones fonéticas. Pese a que solo en contados casos las fuentes ofrecen referencias explícitas a rasgos fonéticos concretos, es posible, sin embargo, aislar algunos: elementos perfectamente observables, como la consonante vibrante múltiple, que denota expresividad y fuerza y representa una de las características más antiguas de la lengua, ya que respalda un papel activo de las lenguas prerromanas (concretamente el vasco) en el rostro sonoro del español.
Deterioros lingüísticos asociados a un caso clínico de demencia tipo alzhéimer
Authors: Jimenez Ruiz Juan Luis , Palenzuela Sánchez Ángeles
Published: September 2021

El presente estudio tiene por objetivo la demarcación y el análisis de la demencia tipo alzhéimer (DTA) a partir de déficits lingüísticos asociados. Presentamos el caso clínico de una paciente desde una aproximación lingüística, así como un panorama general de la patología. Hemos obtenido datos a partir de la observación, registro y análisis de comportamientos lingüísticos, recogidos a través de tareas semidirigidas (enfocadas en producciones orales) y cuestionarios estandarizados. Los datos señalan que los trastornos del sistema nervioso central inherentes al DTA conllevan también alteraciones en las redes que intervienen en el uso correcto del lenguaje. La investigación contribuye a visibilizar los trastornos del habla y su rehabilitación, así como la función del lingüista clínico en el contexto del DTA.
Estudio epidemiológico de histoplasmosis, paracoccidioidomicosis y criptococosis en una zona urbana de Ciudad Guayana, estado Bolívar, Venezuela
Authors: Cermeño Julman R , Alayo Ernesto , Cermeño Julmery J. , Calzadilla Alfredo , Rodríguez Alfredo , Penna Salvador
Published: September 2021

Se realizó un estudio prospectivo con el objetivo de determinar la prevalencia de infecciones por Histoplasma capsulatum, Complejo Paracoccidioides spp. y Complejo Cryptoccocus en individuos que viven o trabajan en la Plaza de las Ciencias del Sur, Puerto Ordaz, en el estado Bolívar, Venezuela, donde se refugian aves migratorias. Se aplicó una encuesta clínico-epidemiológica y se administraron pruebas intradérmicas de histoplasmina y paracoccidiodina, a todos los sujetos participantes en el estudio. A aquellos individuos sintomáticos respiratorios crónicos, se les realizó una evaluación clínica, radiológica, cultivo micológico y estudio serológico (anticuerpos específicos para Histoplasma capsulatum, Complejo Paracoccidioides spp. y del antígeno capsular del Complejo Cryptococcus spp.). Se aplicaron 632 pruebas intradérmicas a 316 individuos. De estos, sólo 296 (93,7%) acudieron a la lectura de las pruebas. Los sujetos tenían una media de edad de 40,3 años (rango: 7-76 años). Las manifestaciones clínicas más frecuentes fueron: tos (n=49; 16,5%), expectoración (n=17; 5,7%) y fiebre (n=8; 2,7%). La prueba para la histoplasmina fue positiva en el 47,3% (n=140) y a la paracoccidioidina, en el 32,4% (n=96). Los factores de riesgos fueron: contacto con palomas 30,4% (n=90) y visitas a fincas con gallineros 29,1% (n=86). Se identificaron dos casos de paracoccidioidomicosis pulmonar (0,7%) y un caso (0,3%) de criptococosis pulmonar. La elevada prevalencia de infección por Histoplasma capsulatum (47,3%) y Paracoccidioides spp. (32,4%) en ambientes urbanos del estado Bolívar, demuestra la necesidad de promover la búsqueda activa de estos hongos patógenos en quienes tienen síntomas respiratorios crónicos, que no mejoran con terapia antibacteriana y que habitan en zonas con características ambientales y geográficas, propicias para el desarrollo de estos hongos.
Industrial revolution 4.0: What should be prepared for the next stage?
Authors: Herawati Adya , Suhermin Suhermin , Anisah Hastin Umi , Sambung Roby
Published: September 2021

This article aims to analyze the opportunities and challenges in the era of the industrial revolution 4.0. This research is a descriptive study with a qualitative approach and uses the literature study method. This study indicates that the opportunities in the era of the industrial revolution 4.0 are in the industrial ecosystem, which is increasingly open, and the challenges are focused on the readiness of human resources. This study formulates that to prepare competitive human resources in the era of the 4.0 industrial revolution, learning in tertiary institutions must be oriented towards a) inter-multi discipline; b) problem solving oriented; c) interpersonal skills, and d) innovation based on technology.
Driver factors of whistleblowing intention in undergraduate student perspective
Authors: Pratiwi Nadya Yunika , Minarso Bambang
Published: September 2021

This research aims to determine the factors that influence the intention of accounting students in Semarang city to as whistleblowers. The data source used is the primary data obtained using a questionnaire given to accounting students in Semarang City 2016 intake with proportionate stratified random sampling and taken is 314 respondents and processed data by multiple linear regression. The results showed that attitudes had no significant effect on intention whistleblowing, while subjective norms and perceived behavioral control significantly affected intention whistleblowing.
Gen Z investment behavior: Does literation in line with intention?
Authors: Arniati Arniati
Published: September 2021

This study aims to reveal the characteristics of literacy and investment intention of Generation Z (Gen Z). This type of research is descriptive with 80 respondents. The results showed that the investment intention of Gen Z was in a good category but was not accompanied by a sufficient level of literacy. This study provides a preliminary offer that the unique characteristics of Gen Z are very likely to lead to higher intention without proper knowledge.
The Analysis of Factors of Formation of the Modern System of Political Governance: Global, Regional and Local Levels
Authors: Tumanov A. D.
Published: September 2021

The relevance of the work is due to the growing inﬂuence of the processes of globalization and the need for a systematic and theoretical understanding of the interdependence of diﬀerent levels of development and adaptation of the political system in the modern world. The situation of the COVID pandemic, which began in 2020 and demonstrated the dominance of global attitudes and rules over regional and local attitudes and rules, gives special relevance to this article. The purpose of the work is to clarify the essence and possibilities of applying system analysis to the process of public administration at the level of global integration, regional and local levels of public administration. At the same time, the essence of system analysis is not reduced to solving problems of management and decision-making on very complex problems, but a complete system and methodology for analyzing the adaptation practices of modern political systems at the global, regional and local levels is built. The author comes to the conclusion that it is the local level that is the basis for the formation of the modern political system, and it is worth focusing on it, and not on the global and regional levels, when carrying out certain political changes and transformations. The regional level is an add-on to the local level, and can include multiple local levels. The task of the regional level is to prevent conﬂict between multiple localities, to ensure their harmonious coexistence and development. Due to the spread of digitalization, the regional level loses its function as an intermediary between the local and the global. The global level of formation of the political system today, in turn, is an “umbrella” level. It appears as a categorical imperative of the political system, but it is not its mandatory guide or guide of development.
Public Property Management in Russian Federation: Basic Principles (Part 2)
Authors: Shulzhenko S. I.
Published: September 2021

The article deals with problems of legal status of state (municipal) bodies and government (municipal) agencies as legal entities in the context of modern Russian treasury budget execution system and underlines the absence of the necessity for their legal entity. Within the framework of budget system reform, the paper regards the right of operational management and the right of permanent perpetual use for the state (municipal) bodies and government (municipal) agencies as anachronism, inherited from the Soviet law, and unnecessary. At the same time the author insists on merging into one institution the right of operational management and the right of permanent perpetual use for budget organizations and autonomous institutions as legal entities and proposes changes to the current legislation.
Rotterdam’s sustainability strategy: a case study on municipal policies
Authors: Różewicz Dominik
Published: September 2021

Rotterdam houses the largest port in Europe. It is a crucial element of the city’s economy, but also a major CO2 emissions generator. Rotterdam’s municipality developed a strategy to responsibly reconcile various interests. The present article aims to show the sustainability strategy adopted in Rotterdam and its primary elements through qualitative research; municipality’s documents were analyzed and the connections between them were stated. This leads to the conclusion that Rotterdam has developed a comprehensive and coherent strategy for sustainable development. The strategy is divided in four elements: energy transition, circularity, climate resilience and a healthy living environment. All elements were developed in response to the city’s existing problems.
Propuesta de indicadores ambientales para un turismo sostenible en el desierto de la Tatacoa, Huila, Colombia
Authors: Giraldo Uribe José Jardani , Sánchez Muñoz María del Pilar , Ruíz Agudelo Héctor Hugo
Published: September 2021

Al considerar el auge que actualmente experimenta el turismo en desiertos y sus efectos, se presenta una propuesta de indicadores para conocer la valoración ambiental en 2019, expresada a través de un índice sintético denominado índice ambiental para el turismo sostenible (IATS) en el desierto de la Tatacoa. La metodología consiste en seleccionar un conjunto de indicadores que toman como referencia la propuesta de indicadores para el turismo sostenible de la Organización Mundial del Turismo, algunos criterios de selección de indicadores y las características específicas del territorio. El resultado es una propuesta que se compone de veintiocho indicadores, de los cuales ocho fueron calculados para la construcción del IATS, el cual permite valorar el estado ambiental del destino turístico como bueno.
Estructura de los tributos territoriales en la ciudad de Manizales, su incidencia en los procesos de mitigación del riesgo medioambiental y el desarrollo sostenible
Authors: Serna Giraldo Diana Sofia , Echeverry Ruiz Luz Dary , Gómez Sánchez Julián Andrés , Serna Mendoza Ciro Alfonso
Published: September 2021

Este trabajo se propone establecer la relación de la tributación territorial de la ciudad de Manizalescon los procesos de mitigación de riesgo medioambiental durante la serie cronológica 2014-2017. Sereflexiona cómo Manizales, durante su desarrollo histórico, se ha venido enfrentando a distintos riesgosa causa de su ubicación geográfica vulnerable desde su planeamiento urbano. Los riesgos propios de laubicación geográfica de la ciudad presentan importantes dilemas. Por esta razón es importante determinarsi se necesita destinar más de los recaudos impositivos o destinar nuevos impuestos para responder ala mitigación de los riegos medioambientales de la ciudad. La principal conclusión es que la asignacióndirecta del presupuesto es una herramienta insuficiente para afrontar los riesgos medioambientales.
Cambios estructurales en índices bursátiles del mercado MILA entre los años 2008 y 2018
Authors: Morales León Nicolás , Vélez Molano José Rodrigo
Published: September 2021

El presente trabajo identifica las posibles fechas de cambios estructurales en los mercados bursátiles que conforman el MILA y sus posibles precursores. Mediante el uso de pruebas clásicas de estabilidad y un estadístico robusto para modelos con heterocedasticidad, se realiza la comparación entre ambas metodologías en las series diarias de los retornos, del precio y el cambio porcentual del volumen de índices accionarios. Para los modelos de los retornos, las fechas de cambio estructural coinciden con eventos de alcance internacional ocurridos en Estados Unidos y Europa, mientras que para los modelos de la variación porcentual del volumen las fechas están en línea con el desempeño de la economía local.
Vulnerabilidad y gestión del riesgo de desastres frente al cambio climático en Piura, Perú
Authors: Córdova Aguilar Hildegardo
Published: September 2021

El cambio climático trae grandes desafíos que de alguna manera afectan el desarrollo sostenible de la vida en la tierra. No solamente se trata de los incrementos de temperatura que, según pronósticos especializados, llevarán a la desaparición de los glaciares tropicales con temperaturas de hasta 48 °C en los trópicos, sino de los impactos de esos incrementos, como son lluvias torrenciales, desertización, inundaciones, pérdida de cultivos, incremento de enfermedades, escasez de agua dulce, etc. Este estudio tiene como objetivo identificar vulnerabilidades ambientales urbanas en algunas ciudades peruanas, tomando como caso a Piura, que viene sufriendo de manera recurrente los impactos desastrosos del fenómeno de El Niño (FEN) con inundaciones, interrupciones de las vías de comunicación y otros sucesos que afectan la calidad de vida de sus habitantes. La metodología empleada es analítica-deductiva basada en bibliografía variada y observaciones de terreno. Como resultado global se ha encontrado escasez de estrategias de resiliencia y de recuperación en favor de las poblaciones más vulnerables frente a los impactos del cambio climático.
Can biogas, generated from cattle waste reduce negative externalities? A case of study in argentina
Authors: Cristiano Gabriela , Buitrago Claudia
Published: September 2021

Lately, Argentina has been promoting renewable energies by implementing several programs. Agroindustrialactivities generate organic waste, which could be treated to mitigate the negative externalities it causes. In this work the results proposed regarding the volume of biogas generation from waste were estimated for a firm in the Corfo region in the province of Buenos Aires. We present an alternative to reduce negative externalities and improve environment through the transformation of biomass into caloric energy, considering the case of a multiproduct firm, in which waste can be the input to produce a new output (biogas and biofertilizer). We determined that, from the effluent generated by 500 heads of cattle, it is possible to obtain 10.125 m3 of biogas/ month, which could be sold or used by the agrarian firm for self-consumption, diminishing its costs.
Dos contrastaciones empíricas de la ley de Wagner: España 1850-2016
Authors: Jaén-García Manuel
Published: September 2021

Este trabajo realiza una doble contrastación empírica de la conocida ley de Wagner de expansión del gasto público. Por una parte se considera una bastante conocida contrastación utilizando instrumentos de raíces unitarias y cointegración. Por otra se utiliza la menos conocida contrastación usando la metodología wavelet. El plazo de tiempo considerado, 1850-2016, es el más largo de los utilizados hasta el momento en cualquier contraste de la ley con datos españoles. Los resultados nos indican que no se puede rechazar la ley de Wagner para la totalidad de la muestra, incluyendo en la ecuación de cointegración y en el MCE las rupturas estructurales, mientras que en la segunda la precedencia del gasto con respecto al PIB y viceversa no permite afirmar el cumplimiento de la ley salvo en períodos de tiempo muy cortos, por ello, y con carácter general, se puede rechazar la ley para el período completo.
Finanzas corporativas en las Empresas de Servicios Públicos de Subachoque y El Rosal Cundinamarca
Authors: López Rodríguez Campo Elías , Gil-Muñoz Michael David
Published: September 2021

Este estudio reconoce la incidencia de las políticas corporativas en la gerencia financiera de las Empresas de Servicios Públicos de Subachoque y El Rosal del departamento de Cundinamarca. A manera reflexiva, sustentada en un enfoque descriptivo, se generó un diagnóstico financiero para identificar los aspectos que influyen en el desarrollo de las políticas corporativas de estas organizaciones, resaltando la incidencia del gobierno corporativo en su desarrollo financiero. Los resultados determinan que estas no incluyen dentro de sus políticas corporativas el apalancamiento financiero de sus operaciones; así mismo, respecto a políticas de inversión, se refleja que están planeando sus presupuestos para cumplir con las obligaciones de funcionamiento, descargando la responsabilidad de generación de valor y crecimiento a las alcaldías municipales.
Aporte socioeconómico y valorización de residuos de trucha en el Encano (municipio de Pasto)
Authors: Ruales Suárez Katherin Julieth , Portillo Melo Danyeli Maricel , Burgos Flórez Marco Antonio , López Macías Jorge Nelson , Ríos Luis Alberto
Published: September 2021

El presente artículo muestra los resultados de la investigación desarrollada en torno al aporte socioeconómico de la producción de trucha en el Encano (Pasto) y tiene como objetivo general, realizar un diagnóstico del estado actual, tendencias y desafíos económicos asociados al proceso de generación de valor agregado a partir de los residuos de la producción de trucha en dicho territorio, teniendo en cuenta el enfoque teórico del desarrollo económico local y la sostenibilidad del medio ambiente. El estudio es de tipo descriptivo, analítico e interpretativo. Metodológicamente se realizó una revisión de variables cuantitativas y cualitativas que permitieron determinar el aporte socioeconómico de la producción truchícola en la región, a partir de la aplicación de entrevistas semiestructuradas a los diferentes actores relacionados con la actividad. Los resultados arrojan que el potencial aprovechamiento de los residuos de esta especie, con el fin de obtener concentrado alimenticio de diferentes grados de hidrolisis de manera técnico-científico a escala piloto, permitiría avanzar en la superación de brechas tecnológicas, productivas y ambientales asociadas a la actividad, pero se requiere coordinar y articular las acciones de los distintos actores sociales involucrados, en torno a la formación de capacidades técnicas y funcionales, transferencia de tecnología e infraestructura.
Contramodernidade Ultra e Conflito no Futebol Contemporâneo
Authors: Pinto (UFRGS) Vinícius Teixeira
Published: September 2021

Hated and Proud é resultado da etnografia de Mark Dyal com grupos de torcedores Ultras da Roma, tradicional clube do futebol italiano. O trabalho apresenta detalhadamente os elementos da presença desta modalidade de torcer nos estádios daquele país, bem como outros aspectos de sua experiência em esferas mais cotidianas da vida. Além disso, destrincha conceitos e categorias próprias desses torcedores com o propósito de pensar os valores que conformam sua moralidade. No panorama teórico, o autor propõe uma abordagem da política nesses grupos para avaliar como se relacionam com torcedores rivais, com Estado e demais agentes do mundo do futebol, o que revela sua condição contra-Moderna. O livro, publicado em 2018, até o momento passou despercebido pelo público brasileiro, no entanto insere um quadro teórico capaz de renovar o interesse a respeito das torcidas organizadas de futebol no país e suas práticas do torcer.
VIOLÊNCIA INTRAFAMILIAR CONTRA A PESSOA IDOSA EM ÁREA URBANA COM SUPORTE DE PROTEÇÃO SOCIAL E DE SAÚDE
Authors: Ribeiro Maria de Nazaré de Souza , Santo Fátima Helena do Espírito , Diniz Cleisiane Xavier , Ribeiro Selma Lira , Nascimento Vanusa do , Ribeiro Euler Esteves
Published: September 2021

Este estudo tem como objetivo estimar a prevalência da violênciacontra a pessoa idosa e investigar como ela se apresenta em áreaurbana com suporte de serviços de proteção social e de saúdedestinados ao atendimento do idoso. Pesquisa quantitativa, transversal e descritiva realizada com 380 idosos residentes na zona sulda cidade de Manaus, área mais equipada com serviços de proteçãosocial e de saúde para idosos. Foi calculada uma margem de errode 5% e Coeficiente de Confiança de 95%. Utilizou-se Instrumentode Avaliação de Violência e Maus-Tratos Contra a Pessoa Idosausado pelo Ministério da Saúde nos Cadernos de Atenção Básica.A prevalência de violência foi de 30,3% e ultrapassou a média demuitos estudos brasileiros. A violência psicológica foi a mais prevalente, com taxa acima da média nacional, seguida da financeira eda física. As variáveis “idade”, “renda familiar”, “violência financeira” e“violência física” apresentaram forte associação (p < 0,05). O númeroampliado de unidades de acolhimento e notificação de violêncianão garantiu prevalência significantemente menor em relação àtaxa nacional, indicando que o problema possa estar nas relaçõesintrafamiliares conflituosas. Sugerem-se estudos que possam identificar a disfuncionalidade familiar como preditora de violência contrapessoa idosa e uma maior atuação das instituições que lidam coma problemática, na promoção de uma cultura de paz no âmbito dafamília e da comunidade.