bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical significance of serum HMGB1 in COPD and correlation with severity of airflow restriction and immune function
Authors: Xu Weiguo , Wu Junhua , Feng Yong , Zhu Jing , Cui Rong
Published: May 2022

Background: To explore the serum HMGB1 levels in patients with smoking-induced chronic obstructive pulmonary disease (COPD) and the correlations with airflow restriction and immune function.

Methods: A total of 136 COPD patients were divided into mild, moderate and severe + extremely severe groups. Thirty-five healthy subjects were selected as control group. Serum HMGB1 levels were measured by ELISA, and the correlations with pulmonary and immune function indices were analyzed. Receiver operating characteristic (ROC) curve was plotted.

Results: PaO2, eosinophil count, FEV1/FVC, FEV1% pred, and IgA, IgM, IgG levels of COPD patients were lower than those of control group, and decreased with airflow restriction aggravation. PaCO2, leukocyte count, neutrophil percentage, modified British Medical Research Council (mMRC) scale and COPD Assessment Test (CAT) scores, D-Dimer (D-D), PCT, CRP and HMGB1 levels, myeloid dendritic cell (mDC) and plasmacytoid dendritic cell (pDC) counts, and mDCs/pDCs of COPD patients exceeded those of control group, and increased with airflow restriction aggravation (P<0.05). HMGB1 levels of COPD patients were negatively correlated with FEV1/FVC, FEV1% pred, IgA, IgM and IgG levels and positively correlated with mDC count, pDC count and mDCs/pDCs (P<0.0001). The area under ROC curve was 0.883, the optimal cutoff value was 3.63 ng/mL, and sensitivity and specificity were 86.7% and 85.9%, respectively.

Conclusions: Serum HMGB1 level in patients with smoking-induced COPD rises with airflow restriction aggravation and has significant correlations with the decline of pulmonary and immune functions, with high predictive value for COPD. HMGB1 is a potential biomarker for evaluating COPD progression.
Approaching Risk Management in Medical Laboratories
Authors: David Remona Eliza
Published: May 2022

Risk is one of the greatest challenges in a medical laboratory. Risk-based thinking is a concept that always preoccupies medical laboratory technicians. The objectives of this work were to bring forward the specialty standards recommendations for the implementation of risk management principles in medical laboratory, the accreditation requirement of ISO 15189:2012; to demonstrate that the understanding of the fundamental notions of the concept of risk, the effectively apply of the means of identifying, assessing and controlling risks, and the risk monitoring and handling through strategies of acceptance, elimination, transfer and mitigation of risks can ensure the continuous improvement processes. A model to approach to risk management in a medical laboratory establishes the inputs, the outputs, the techniques, and the activities carried out in each of the following sub-processes of the risk management process: risk management process planning, risk identification, risk analysis and evaluation, development of the risk response plan and risk monitoring, control and revision. The concepts of risk and risk management are applied accordingly to standards ISO 31000:2018 and ISO 22367:2020 of International Organization for Standardization (ISO). Risk management ensures that the fundamental requirements for healthy, proactive internal control of the medical laboratory are met.
Experimental and Numerical Study on the Efficiency of the Repair of Composite Structures Cracked and V-Notched By Different Types and Shapes of Composite Material Patch
Authors: Berrahou Mohamed , Amari Kaoula
Published: May 2022

The subject of this article around two studies, including experimental and numerical, aiming to know the efficiency of the repair of a composite plate notched (V-shape) and cracked by composite patches of different (types and shapes) . The experimental study to find out which composite materials and shapes are resistant to fracture and notch, We used the finite element method (ABAQUS) for the numerical study to follow the variation of the damaged area ratio DR, the stress intensity factor SIF and the stress distribution as a function of the crack size for located the most effective shape and type patch in repairing cracks and notch. From the results found we can deduce that the best type of patch used is Boron / epoxy and the full shape is the most efficient and resists structural failure, this is confirmed by the experimental test.
Effect of Load Eccentricity on Stress Condition of Butt Welded Joint with Asymmetrical Reinforcement
Authors: Moltasov Andrii , Tkach Pavlo , Ustynenko Oleksandr , Protasov Roman
Published: May 2022

An analytical method for determination of a stress condition of butt welded thin-gauge plates with asymmetrical reinforcement is developed. The proposed method allows take into account the effect of the load application eccentricity on the tensile stress concentration factor (SCF) in the weld root zone. It is presented that the bending stresses, caused by this eccentricity, result in increasing the total stresses up to 75%. The results of analytical SCF calculations are in good agreement with the results obtained using the finite element method.
Multi Sources Information Fusion Based on Bayesian Network Method to Improve the Fault Prediction of Centrifugal Compressor
Authors: Nessaib Karim , Lakehal Abdelaziz
Published: May 2022

The centrifugal compressor is an important machine in the oil and gas industry, so the fault prediction of these machines is widely discussed in the literature. Several techniques can and should be used in fault prediction of centrifugal compressors: vibration analysis, non-destructive testing techniques, operating parameters, and other techniques. But in particular cases, these tools are inefficient for making a decision regarding the combined fault diagnosis and prediction. This paper presents a contribution to fault prediction in centrifugal compressor utilizing multi-source information fusion by a Bayesian network. The data fusion does not come from the same source, but rather from vibration analysis, oil analysis, and operating parameters. In addition, the accuracy and ability of fault prediction can be improved compared with the use of data obtained from vibration analysis only or oil analysis. The proposed method accuracy is validated on a BCL 406 type centrifugal compressor. Furthermore, the obtained results showed the effectiveness of the multi-source information fusion by Bayesian network approach gives more accuracy to decision-making in fault prediction and the developed method has an effect in predicting the combined faults.
Analysis of the Financial Leverage Effect in the Context of Interest Rates Increase
Authors: Ionescu Luiza , Toma Maria , Founanou Mathurin
Published: May 2022

The main objective of this paper is to demonstrate the importance of a tool, called in the specialized literature, financial leverage effect, in managerial decision-making process, regarding the way to finance the assets and finding an optimal indebtedness. The research context comes as a result of the recently increase in the inflation rate, at global, European and national level. This fact led the national central banks to revise their monetary policies, mainly through the monetary policy increases interest rate. As a consequence, the commercial banks (which borrow money from the Central or National Bank) grant more expensive loans to commercial companies. Theoretical research on the conceptual approach is complemented by the case study method, whose results show that an increase in the interest rate on loans contracted by the companies, can lead to a decrease in the financial leverage effect value, until reaching even negative values.
Increasing the Efficiency of The Romanian Tourism Sector by Improving the Service Management and using Mathematical Modeling
Authors: Sayin Ferhan , Croitoru Gabriel , Robescu Valentina Ofelia , Florea Nicoleta Valentina
Published: May 2022

The topicality and necessity of the topic is motivated by the usefulness and necessity of approaching, from a new perspective, the development of the southeastern region of Romania through some important features in the increasingly challenging era of the prohibitions imposed by COVID 19, some knowledge which tries to answer the increasing complexity of economic and social realities, interactive and innovative approaches, analysis and promotion of the natural and anthropic potential of this tourist area and tourism enterprises, activities accomplished by them and attracting foreign investors, practices made public by managers in the tourism sector. Viewing the statistics on the development and delivery of quality in national and regional tourism, identifying long-term strategies, insufficiently studied, can determine a continuous improvement in the quality of tourism products and services, combined with managerial practices to meet the tourists’ needs, facilitating the growth of the profits. In order to improve the quality of the services in the tourism sector, by training / qualifying the staff, the customer orientation through some tourism promotion and information policy, the conservation and preservation of the sustainable environment, the visualization of managerial practices, methods of investigation, analysis, survey, questionnaire, observation, comparison, being completed more stages: documentation (consultation of representative works in the tourism sector), then the research of some empirical facts (practical reality data), fact which gives the whole approach the character of scientific work. Given the specificity of the data, the Spearman correlation coefficient and the Hi correlation coefficient (x2) were used to analyze the links and correlations between different items and different variables related to the sample, to validate the research hypotheses.
АКТУАЛЬНІ ПРОБЛЕМИ ПІДГОТОВКИ КВАЛІФІКОВАНИХ ВЧИТЕЛЬСЬКИХ КАДРІВ У СФЕРІ МУЗИЧНОГО МИСТЕЦТВА
Authors: Стець Галина , Кишакевич Світлана
Published: May 2022

У статті висвітлено й охарактеризовано актуальні питання підготовки майбутніх вчителів-музикантів до педагогічної діяльності. На основі аналізу наукових праць українських вчених-педагогів доведено, що проблеми підготовки вчителя музичного мистецтва безпосередньо пов’язані зі стратегією розвитку музично-педагогічної освіти та впливають на інноваційні перетворення її змісту.
Зазначено, що ключовою проблемою забезпечення якісної музично-педагогічної освіти є питання формування педагогічної майстерності, компетентності та мобільності майбутнього вчителя-музиканта, що виявляється у здатності свідомо перебудовувати свою діяльність відповідно до запитів суспільства у сфері освітніх послуг.
РЕСУРСИ ОСВІТНЬОГО СЕРЕДОВИЩА ЛІЦЕЮ ДЛЯ ФОРМУВАННЯ ГРОМАДЯНСЬКОЇ АКТИВНОСТІ УЧНІВСЬКОЇ МОЛОДІ
Authors: Гершуненко Ольга , Пащенко Дмитро , Примаченко Наталія
Published: May 2022

У статті йдеться про необхідність формування громадянської активності ліцеїстів, обґрунтовуються погляди на освітнє середовище закладу освіти різними вченими, розглядаються критерії освітнього середовища для формування громадянської активності; визначаються основні сутнісні характеристики освітнього середовища та необхідні ресурси для формування громадянської активності ліцеїстів.
ТЕОРЕТИЧНІ АСПЕКТИ АДАПТАЦІЇ МАЙБУТНІХ УЧИТЕЛІВ ФІЗИЧНОЇ КУЛЬТУРИ ДО ПРОФЕСІЙНОЇ ДІЯЛЬНОСТІ
Authors: Маріонда Іван , Сивохоп Едуард , Тулайдан Вікторія
Published: May 2022

У статті розглянуто теоретичні аспекти адаптації майбутніх учителів фізичної культури до професійної діяльності. Проаналізовано проблему підготовки майбутніх учителів фізичної культури. Обґрунтовано напрями вдосконалення підготовки майбутніх учителів фізичної культури до адаптації професійної діяльності на розвиток професіоналізму, інтеграцією професійних надбань до професійної діяльності. З’ясовано, що у сучасних умовах фізична освіта майбутніх фахівців зорієнтована на підготовку педагогічних кадрів здатних на впровадження європейських освітніх стандартів, на якісну адаптацію до професійної діяльності. Зазначено значимість інтенсифікації освітнього процесу на адаптацію майбутніх учителів фізичної культури до професійної діяльності у процесі педагогічної практики.
РОЛЬ РУХОВОЇ АКТИВНОСТІ СТУДЕНТІВ У ПРОЦЕСІ ВИКОРИСТАННЯ ЗАСОБІВ СПОРТИВНИХ ІГОР НА ЗАНЯТТЯХ З ФІЗИЧНОГО ВИХОВАННЯ
Authors: Базильчук Віра , Базильчук Олег , Дутчак Юрій
Published: May 2022

У статті здійснено аналіз науково-педагогічного дискурсу проблеми рухової активності студентів у процесі використання засобів спортивних ігор на заняттях з фізичного виховання. Систематизовано погляди на організацію фізичного виховання у ЗВО, а також наголошується на важливості спортивних ігор на заняттях з фізичного виховання. Визначено пріоритетні види спорту, якими займаються студенти і до яких віднесено футбол, баскетбол, регбі, волейбол. Дещо менша кількість учасників опитування прагнуть займатися на заняттях з фізичного виховання гандболом, футзалом, бадмінтоном, настільним тенісом.
ОСОБЛИВОСТІ ПОЕТИКИ ЛІТЕРАТУРНИХ КАЗОК ДЖ.Р.Р. ТОЛКІНА (НА ОСНОВІ ЗБІРКИ “СКАЗАННЯ З НЕБЕЗПЕЧНОГО КОРОЛІВСТВА”)
Authors: Куцик Андрій
Published: May 2022

У статті проаналізовано особливості літературної казки на прикладі чарівних історій Дж. Р. Р. Толкіна “Сказання з Небезпечного Королівства”: “Роверандом”, “Фермер Джайлз із Гема”, “Коваль із Великого Вуттона”, “Листок пана Дрібнички” та “Пригоди Тома Бомбадила”; виявлено, що вони пов’язані з міфами, однак читач сприймає їх як самостійний естетичний феномен, казки поєднують чарівних, дивовижних та фантастичних персонажів, запозичених з різних джерел.

Простежено, що замкнений світ казок Толкіна приваблює читача цілісністю, завершеністю та чарівністю, а події відбуваються у так званому антисвіті (Дивокрай, світ картини пана Дрібнички).З’ясовано, що антисвіт характеризується власною замкненістю, з усіма атрибутами казки (здатність розмовляти у тварин, рослин та іграшок, чарівні предмети тощо); часопростір організовано в казках пунктиром – з фіксацією ключових моментів сюжету, хронотоп має властивість у чарівний спосіб стискатися.
СТРУКТУРНІ КОМПОНЕНТИ СОЦІАЛЬНОЇ МОБІЛЬНОСТІ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВОЇ ШКОЛИ
Authors: Галюка Ольга
Published: May 2022

У статті розглянуто зміст поняття “соціальна мобільність учителя початкової школи”. Проведено аналіз теоретичних праць українських та зарубіжних фахівців, який свідчить, що у контексті дослідження структури соціальної мобільності не існує однозначного тлумачення змісту її складових. Окремо визначено структуру й охарактеризовано зміст компонентів соціальної мобільності майбутніх учителів початкової школи, зокрема, мотиваційно-цільового, адаптаційного, соціально-ситуаційного, рефлексивно-діяльнісного.
ANALISIS PENYEBAB KETIDAKLENGKAPAN PENGISIAN INFORMED CONSENT DI RSUD dr. ABDOER RAHEM SITUBONDO
Authors: Pratiwi Irene Anjar , Ardianto Efri Tri , Deharja Atma , Muflihatin Indah
Published: May 2022

Ketidaklengkapan pengisian informed consent kasus bedah umum pasien rawat inap di RSUD dr. Abdoer Rahem Situbondo terjadi kenaikan setiap bulannya pada trimester I tahun 2019, kenaikan tertinggi terjadi pada bulan Maret yaitu sebesar 74% dari sebelumnya 64% pada bulan Februari. Berdasarkan aturan Menteri Kesehatan RI No. 129 Tahun 2008, standar minimal pengisian informed consent yaitu 100%. Tujuan dari penelitian ini adalah untuk menganalisis faktor penyebab ketidaklengkapan pengisian informed consent kasus bedah umum pasien rawat inap di Rumah Sakit Umum Daerah dr Abdoer Rahem Situbondo menggunakan teori kinerja Simamora. Jenis penelitian yang digunakan dalam penelitian ini adalah analisis kualitatif. Teknik pengumpulan data yang digunakan yaitu wawancara, kuesioner, dokumentasi, CARL (Capability, Accessibility, Readiness, Leverage) dan brainstorming. Studi pendahuluan dilaksanakan pada bulan Januari sampai Februari 2020. Data yang diambil adalah formulir informed consent kasus bedah umum pasien rawat inap yang telah dikembalikan ke unit rekam medis. Hasil yang didapatkan dari penelitian ini yaitu tidak pernah dilakukan evaluasi ketidaklengkapan pengisian informed consent, tidak terdapat penghargaan yang diberikan terhadap kinerja pengisian informed consent, tidak pernah diadakan pembelajaran seperti seminar atau pelatihan mengenai pengisian informed consent.
A Continuous Lipase-Catalyzed Acylation Process for the Large-Scale Production of Vitamin A Precursors
Authors: Orsat Bernard , Wirz Beat , Bischof Stefan
Published: May 2022

A continuous enzyme-catalyzed acylation process for the selective preparation of monoacylated Vitamin A precursors starting from a 1,6-diol on a large scale is reported. Screenings led to the selection of the commercially available immobilized lipase Chirazyme L2-C2 (lipase B from Candida antarctica) as the biocatalyst, different vinyl acylates as the acylating agents, and acetone as the co-solvent. Using a mixture of 70% (v/v) acetone and acylating agent allowed to increase the substrate concentration from 10 to 30% (w/w). Using a small fixed-bed reactor, this continuous process produced monoacylated product with >99% yield and >97% selectivity for the primary hydroxy group. The robustness of this system under different conditions was investigated. Consequently, the stability of the biocatalyst could be greatly improved by adding a protective pre-column and by adding small amounts of organic base and antioxidant to the substrate solution. This optimized laboratory process was used to selectively prepare monoacylated compounds in kilogram scales over one hundred days with only a minor decrease in conversion efficiency. The process was also implemented in an up-scaled mini plant for the continuous production on a kilogram-per-day scale, reproducing the results previously obtained on smaller laboratory scales.
Combinatorial Chemistry
Authors: Zenobi Renato
Published: May 2022

In many areas of chemical synthesis, drug discovery, and materials research, combinatorial approaches are becoming more and more important. One of the most serious bottlenecks in this area is the chemical analysis and screening of the products. Was the correct product produced? Were
all the possible products produced? What is their purity? Where in a combinatorial library are the 'hits'? If a relatively large number of lead compounds or hits have been identified, what is the most effective way for their thorough chemical analysis? The key goals of this symposium were
to provide an overview over the current state-of-the-art analytical strategies used in combinatorial chemistry, and to show how obstacles can be overcome by new analytical tools and strategies. It was fascinating to experience how many areas of chemistry are influenced by combinatorial chemistry
nowadays, and it was impressive to witness the efforts being made by software developers and chemists alike to overcome some remaining hurdles in this area.
Some Basic Principles of Patents
Authors: Grubb Philip W.
Published: May 2022

This article gives a basic introduction to patents, dealing with the questions of what a patent is and what rights it gives, how a patent may be applied for, what inventions are patentable, and what are the functions of the patent specification and claims.
Developments in International Patent Law Harmonization
Authors: Baechtold Philippe
Published: May 2022

It is well known that efforts to achieve worldwide harmonization of patent systems are not yet complete. Early work on building a complete system, however, started as early as the late 19th century, when the Paris Convention on the Protection of Industrial Property was concluded. Since
that time, many steps towards a comprehensive harmonization of patent legislation have been taken on the national, regional and worldwide levels. The present contribution outlines these efforts and attempts to demonstrate that current developments are preparing the path for further harmonization
of patent law in the future, whereby modern information technologies may play a decisive role. For the World Intellectual Property Organization, the main challenges consist in finalizing the Patent Law Treaty on patent formalities at a Diplomatic Conference in May and June of this year, and,
subsequently, to endeavor to further harmonize patent laws as well as to study possible developments of the Patent Cooperation Treaty. In order to fully achieve these goals, it will be necessary that all circles involved concentrate their attention on further cost reductions and simplification
of patent procedures in the interests of the users of the patent system worldwide.
Biotechnology and Patents
Authors: Straus Joseph
Published: May 2022

Legal nature, macro and micro economic importance of patents, differences in propensity towards patenting and their consequences. Brief comparison of US and European patent law with regard to patentability of biotechnological inventions. The regime adopted under the EU Biotechnology
Directive, especially as regards the patentability of DNA sequences, as well as plants and animals. Addressed were also the issues of prior informed consent in case of the use of biological material of human origin and the implications of early publication of raw sequence data.
Labeling Monoclonal Antibodies with Metal Complexes: A Challenge for Coordination Chemists
Authors: Kaden Thomas A.
Published: May 2022

Three examples are used to show how the coordination chemist can develop macrocyclic ligands for labeling monoclonal antibodies used in nuclear medicine for tumor diagnosis and therapy.
Polymer-Bound Halogen Bonding Organocatalysis
Authors: Papagna Raffaella , Kutzinski Dana , Huber Stefan
Published: May 2022

Noncovalent organocatalysts utilizing halogen bonding have emerged in the last decade as efficient alternatives to more established hydrogen bonding donors. However, currently they often cannot be recycled and, in some cases, even stoichiometric amounts need to be used. Herein, we present the first generation of recyclable, polymer-bound halogen bonding catalysts which are able to catalyze a halide abstraction reaction. To this end, bis(benzimidazolium)-based halogen bonding units were attached to a polystyrene polymer, yielding insoluble catalysts. These could be recycled up to three times with little loss in catalytic activity. The overall performance of the catalysts is comparable to that of a free (non-polymer-bound) halogen bond donor. Interestingly, catalysts featuring a preorganized and a non-preorganized halogen bond donating unit showed comparable activity, in contrast to the situation of the free donors. This proof-of-principle study provides the basis for further steps towards more sustainable halogen bonding organocatalysts.
Ortho-substituted aryldiazonium design for defect configuration-controlled photoluminescent functionalization of chiral single-walled carbon nanotubes
Authors: Yu Boda , Naka Sadahito , Aoki Haruka , Kato Koichiro , Fujigaya Tsuyohiko , Shiraki Tomohiro
Published: May 2022

Defect functionalization using chemical modification of single-walled carbon nanotubes (SWCNTs) is promising, especially for near-infrared photoluminescence (NIR PL) over 1000 nm in advanced telecom and bio/medical applications. The covalent attachment of modifier molecules is utilized to create sp3 carbon defects in the sp2 carbon lattice for bright, red-shifted PL generation. The positional difference in proximal sp3 carbons, known as the defect binding configuration, can dominate NIR PL properties; however, the defect arrangement chemistry remains unelucidated. We developed aryldiazonium modifiers with -conjugated ortho-substituents (phenyl and acetylene groups) to introduce molecular interactions with nanotube sidewalls into the chemical reaction process for defect formation. Single defect emissions of ~1230–1270 nm selectively appeared in the functionalized chiral SWCNTs, showing a different binding configuration from those observed for typical aryl- or alkyl- functionalized chiral tubes emitting approximately 1150-nm PL. Moreover, the acetylene-based substituent design allows PL brightening and subsequent molecular modification using click chemistry.
In-situ Multi-Mode Extraction (iMME) sampler for a wide-scope multi-residue analysis of > 100 chemicals of emerging concern (CEC) and antimicrobial resistance genes in the aqueous environment in urban areas and remote (off-the-grid) locations
Authors: Sims Natalie , Holton Elizabeth , Archer Edward , Botes Merelize , Wolfaardt Gideon , Kasprzyk-Hordern Barbara
Published: May 2022

Chemical pollution (including chemicals of emerging concern – CECs) continues to gain increasing attention as a global threat to human health and the environment, with numerous reports on the adverse and sometimes devasting effects upon ecosystems the presence of these chemicals can have. Whilst many studies have investigated presence of CECs in aquatic environments, these studies have been focused on higher income countries, leaving significant knowledge gaps for many low-middle income countries. This study proposes a new integrated powerless, in-situ multi-mode extraction (iMME) sampler for the analysis of chemicals (105 chemicals of emerging concern, CECs) and biological (5 genes) markers in water in contrasting settings: an urbanized Avon River in the UK and remote Olifants River in Kruger National Park in South Africa. The overarching goal was to develop a sampling device that maintains integrity of a diverse range of analytes via analyte immobilization using polymeric and glass fibre materials, without access to power supply or cold chain for sample transportation. Chemical analysis was achieved using ultra-performance liquid chromatography coupled with tandem mass spectrometry. Several mobile CECs showed low stability in river water, at room temperature and typical 24h sampling/transport time. It is therefore recommended that, in the absence of cooling, environmental water samples are spiked with internal standards on site, immediately after collection and analyte immobilization option is considered. iMME has proven effective in immobilization, concentration and increased stability of CECs at room temperature (and at least 7 days storage) allowing for sample collection at remote locations. The results from the River Avon and Olifants River sampling indicate that the pristine environment of Olifants catchment is largely unaffected by CECs common in the urbanized River Avon in the UK with a few exceptions: lifestyle chemicals (e.g., caffeine, nicotine and their metabolites), paracetamol and UV filters due to tourism and carbamazepine due to its persistent nature. iMME equipped with an additional gene extraction capability provides an exciting new opportunity of comprehensive biochemical profiling of aqueous samples with one powerless in-situ device. Further work is required to provide full integration of the device and comprehensive assessment of performance in both chemical and biological targets.
Carbodiimide-induced formation of transient polyether cages
Authors: Hossain Mohammad Mosharraf , Jayalath Isuru M. , Baral Renuka , Hartley C. Scott
Published: May 2022

The use of “fuel” compounds to drive chemical systems out of equilibrium is currently of interest because of the potential for temporally controlled, responsive behavior. We have recently shown that transiently formed crown ethers exhibit counterintuitive templation effects when generated in the presence of alkali metal cations: “matched” cations, such as K+ with an 18-crown-6 analogue, suppress the formation of the macrocycles (negative templation). Here we describe two macrocyclic diacids that, on treatment with carbodiimides, give transient macrobicyclic cages analogous to polyether cages first reported by Parsons. Cage formation was followed by NMR spectroscopy. Similar negative templation effects are observed for the smaller cage when generated in the presence of K+ and Na+, but with a weak, but reproducible, positive templation effect in the presence of Li+. The larger cage behaves similarly in the presence of Li+, K+, Rb+, and Cs+, but differently with Na+, which appears to bind to both the cage and the initial macrocycle.
Structure-based discovery of multitarget directed anti-inflammatory p-nitrophenyl hydrazones; molecular docking, drug-likeness, in-silico pharmacokinetics, and toxicity studies.
Authors: Babalola Sodeeq , Igie Nosakhare , Odeyemi Isaiah
Published: May 2022

We designed novel p-nitrophenyl hydrazones as multi-target inhibitors of COX-2, 5-LOX, and H+/K+ ATPase in a bid to overcome side effects associated to NSAIDs and coxibs. Specifically, compounds 3, 6, 8, 11, 13, 14, 16, and 17 indicated promise as potent multi-target inhibitors of COX-2, 5-LOX, and H+/K+ ATPase with potential anti-inflammatory activity devoid of adverse effects of NSAIDs. Interactions with important amino acid which are key for ant-inflammatory activity and proton pump inhibition were noticed. All the compounds are less COX-2 selective compared to celecoxib. These compounds in addition have shown druglike physicochemical properties, passed Lipinski’s, Egan’s, Veber’s, Muegge’s and Ghose’s rules for druglike small molecules and orally bioavailable drugs. The compounds also passed golden triangle’s rule for potent and metabolically stable drugs. Also, these compounds passed Pfizer and GSK rules. The compounds also indicated excellent pharmacokinetic profiles complementing their potential anti-inflammatory activity with apparent safety profiles.
Interactive Software for Visualization of Non-Targeted Mass Spectrometry Data – FluoroMatch Visualizer
Authors: Koelmel Jeremy , Stelben Paul , Godri David , Qi Jiarong , McDonough Carrie , Dukes David , Aristizabal-Henao Juan , Bowden John , Sternberg Sandi , Rennie Emma , Godri Pollitt Krystal
Published: May 2022

There are thousands of different per- and polyfluoroalkyl substances (PFAS) in everyday products and in the environment. Discerning the abundance and diversity of PFAS is essential for understanding sources, fate, exposure routes, and the associated health impacts of PFAS. While comprehensive detection of PFAS requires use of non-targeted mass spectrometry, data-processing is time intensive and prone to error. While automated approaches can compile all mass spectrometric evidence (e.g., retention time, isotopic pattern, fragmentation, and accurate mass) and provide ranking or scoring metrics for annotations, confident assignment of structure often still requires extensive manual review of the data. To aid this process, we present FluoroMatch Visualizer which was developed to provide interactive visualizations which include normalized mass defect plots, retention time versus accurate mass plots, MS/MS fragmentation spectra, and tables of annotations and meta-data. All graphs and tables are interactive and have cross-filtering such that when a user selects a feature, all other visuals highlight the feature of interest. Several filtering options have been integrated into this novel data visualization tool, specifically with the capability to filter by PFAS chemical series, fragment(s), assignment confidence, and MS/MS file(s). FluoroMatch Visualizer is part of FluoroMatch Suite, which consists of FluoroMatch Modular, FluoroMatch Flow, and FluoroMatch Generator. FluoroMatch Visualizer enables annotations to be extensively validated, increasing annotation confidence. The resulting visualizations and datasets can be shared online in an interactive format for community based PFAS discovery. FluoroMatch visualizer holds potential to promote harmonization of non-targeted data-processing and interpretation throughout the PFAS scientific community.
Public Perceptions and Attitudes Towards People with Arson Convictions: A Preliminary Examination and Comparison with Sexual Convictions
Authors:   , Nichols Tara
Published: May 2022

People with arson convictions face significant reintegration barriers that have the potential to compromise the desistance process. Public perceptions and attitudes have been identified as one factor which can impact the range and quality of reintegration opportunities necessary to support desistance. However, limited research to date has examined public perceptions and attitudes towards people with arson convictions. The current thesis sought to address this gap in the existing literature using two interlinked studies. Study 1 utilised a qualitative online survey with 60 student participants to qualitatively examine the content and valence of perceptions and attitudes towards people with arson convictions. Study 2 used a between-subjects experimental design to quantitatively examine similarities and differences in public perceptions and attitudes between individuals with arson and sexual convictions in a sample of 198 community participants. In addition, four open-ended questions were analysed using summative content analysis to explore the primary concerns underpinning participants’ perceptions and attitudes. This research provides novel insight into the public perceptions, attitudes, and underlying concerns related to people with arson convictions. These findings have potential implications for policy and practice and can be used to inform future empirical research.
Contaminant transport model in transient and unsaturated conditions applied to laboratory column test with tailings
Authors: Carbaja Eliu , Diniz Mariana , Rodriguez-Pacheco Roberto , Cavalcante André
Published: May 2022

Mining is an important economic activity in the modern world. However, despite the generated benefits, mining produces tremendous volumes of tailings, an environmental liability with numerous adverse effects. Researches about contaminant transport in tailings dam are important to assess the degree of contamination and to propose preventive or remedial measures. In geotechnical practice, the flow of solutes is generally characterized by numerical solution of the Richards equation to describe water movement followed by advection-dispersion equation to describe contaminant movement. This study aimed to model and simulate contaminant transport in a laboratory column test, using a new analytical formulation and mathematical codes, through tailings in transient unsaturated conditions. The analytical solution for the Richards equation was used to simulate the variation in the volumetric water content and to determine the transient contaminant plume using the advection-dispersion equation subsequently. The models were used to calibrate experimental data from hydraulic characterization and contamination tests. Finally, the normalized contaminant plume (cw/c0) was simulated as a function of time and space. Comparisons with experimental data showed that the analytical formulations adequately expressed the process of contaminant infiltration through the unsaturated porous medium. The formulations offered effectively and are configured as a new approach to solve various contamination problems in transient unsaturated conditions, providing insights into many complex processes that occur in the lab tests and requires far less computational effort compared with current programs to modeling the solute transport using numerical solutions, as the versatile commercial Software HYDRUS.
Table of Contents: Issues in Informing Science and Informing Technology. Volume 19, 2022
Authors: Cohen Eli
Published: May 2022

Table of Contents for IISIT Volume 19, 2022
Geoelectrical resistivity survey to determine sliding surface of landslides prone area case study in Ponjong subdistrict Gunung Kidul regency Indonesia
Authors: Rizqi Al Hussein Flowers , Sugarbo Oky , Pitaloka Mayang
Published: May 2022

The research area is located in Ponjong Subdistrict, Gunung Kidul Regency. Ponjong area specific at Tambakromo village is one of potential in landslides disaster since 2011. The outspread information about landslide and mitigation should be done in research area. The aim of this research is to get the subsurface condition and determine of landslide surface based on geoelectrical resistivity in Tambakromo area, Ponjong Subdistrict, Gunung Kidul regency. The method of this research is used geoelectrical survey by using Dipole - dipole configuration. The result of this research is the lithology of sliding surface is claystone – fine tuffaceous claystone with resistivity value of 29.9 ohmmeter based on Dipole – dipole subsurface cross section at Grogol village. The sliding surface could be found at 5 metres to 20 metres underground. At Sumberejo village, based on dipole-dipole subsurface the lithology of sliding surface is claystone – fine tuffaceous claystone with resistivity value of 6.18 to 29.9 ohmmeter at depth of 20 to 25 metres. Based on the regional stratigraphy correlation showed that the claystone or tuffaceous claystone is included in Semilir Formation. This research should be able to held for local government to proved landslide mitigation in research area.
Peningkatan Efisiensi Penggunaan Bahan Bakar Terhadap Produktivitas Hasil Proses Penyulingan Sereh Wangi Menggunakan Sistem Kohabasi Untuk Mendukung Kegiatan Agro-Industri
Authors: Poerwanto Eko , Hariyanto Kris
Published: May 2022

One way to isolate essential oils from essential oil-producing plants is by distillation. Distillation is the separation of components in the form of a liquid consisting of two or more kinds of mixtures based on differences in boiling points. The process is carried out on essential oils that are not soluble in water. The distillation process that has been used so far is by using steam and water, because the equipment construction is cheaper and simpler. However, steam and water distillation has a disadvantage, namely that it requires more water vapor. This will result in a certain amount of steam condensing in the plant tissue so that the material will get wetter so that it will increase the use of fuel and will reduce the productivity of the distillation process. To overcome this, it is necessary to strive for a more effective distillation system.This research was conducted with the aim of increasing the combustion efficiency of the essential plant distillation process, namely citronella, so that it is expected to increase the productivity of the distillation. This research was carried out by changing the distillation system using the cohobation system. Boyolali.The results showed that the efficiency of the kohobasi furnace distillation system was 0.85% higher than the steam distillation system, these results were in line with the productivity level of the citronella oil distillation production process, so for the work program of the Guli Village Government it was recommended to use the kohobasi furnace distillation system
Manufacturing process and experimental study of a small scale archimedes hydro powerplant by varying the number of blade
Authors: Abdillah Helmi Fauzan , Dinaryanto Okto , Jalaali Bahrul
Published: May 2022

This study investigated the optimum value of Archimedes Screw Turbine (AST) performance by taking into account blades number. This paper also addressed the design approach based on a fixed incline angle of 30°, where this paper also addressed the design approach. Variations of the single and double blades were experimentally carried out concerning the turbine power output, torque, and rotation speed. This study's aim was related to the optimum power output between two blade variations, while the manufacturing and design steps were addressed as well. In the design process, the obtained blade length dimension was 0.180 m and 0.269 m for the single and double blades. Furthermore, the overall turbine's length was 1.7m, and the inner and outer of the turbine's radius were 0.069m and 0.128m. Meanwhile, the manufacturing process began with turbine modeling, plate cutting, plate withdrawal (thread formation), welding, and attained finishing process. Based on the experimental result, a double blade turbine generated turbine power by 48.8W at an average rotational speed of 115.3 rpm. Moreover, a single blade turbine produced 37.5W with turbine power averaging a rotational speed of 109.8 rpm. It was obtained that the values of turbine efficiency were 42% and 38% for double and single turbine types, respectively. Based on this finding, it can be suggested that a double blade was more efficient than a single one. This study is beneficial for the design consideration of the AST system.
Öğretmen Adaylarının Görüşlerine Göre Vatanseverlik
Authors: KAN Çiğdem
Published: May 2022

Vatansever olma konusunda eğitim, kültür, aile ve çevre koşulları etkilidir. Bu çalışmanın amacı, sosyal bilgiler öğretmen adaylarının vatanseverlik anlayışlarını ortaya koymaktır. Çalışma, 2017-2018 bahar yarıyılında Fırat Üniversitesi
Eğitim fakültesinde gerçekleştirilmiştir. Çalışma grubu, 24 sosyal bilgiler öğretmen adayından oluşmaktadır. Genel tarama türünde olan çalışmada, yarı yapılandırılmış görüşme formuyla veriler toplanmıştır. Elde edilen veriler,
betimsel analiz tekniği kullanılarak çözümlenmiştir. Çalışmanın bulgularına göre, öğretmen adayları vatanseverliği kişinin ülkesini, bayrağını ve insanlarını sevmesi ve sahiplenmesi, ülkenin ilerlemesi için bireylerin çaba sarf
etmesi ve sorumluluk bilinci olarak tanımlamışlardır. Öğretmen adayları vatansever olduklarını vurgulayarak, sorumluluklarının bilincinde olduklarını ve vatansever öğrenciler yetiştirmek istediklerini belirtmişlerdir. Öğretmen
adaylarına göre vatansever olup olmamanın arkasındaki nedenler ise, toplumun değerleriyle ilgili olduğu, vatanını sevmeyenin bencil ve sorumsuz olduğunu ve vatanseverliğin bilinçli olmakla ilgili olduğu açıklanmıştır.
Accounting Of Currency Protected Deposit Account Under TFRS 9
Authors: AKGEMCİ Ahmet
Published: May 2022

Kur korumalı mevduat hesabında (KKMH) hesabın açılış tarihindeki döviz kuru , vade sonundaki döviz kurundan yüksekse ve mevduat hesabı sahibinin elde edeceği faiz/katılım payı gelirleri ,döviz kuru artışlarından elde edeceği kambiyo
karının altında olduğu durumlarda ilgili fark merkez bankasınca mevduat hesabı sahibine ödenmektedir. Buradaki temel amaç dövize olan aşırı talebi engelleyerek Türk Lirasının değerini korumaktır. Bu kapsamda Cumhurbaşkanlığı, Maliye
Bakanlığı ve Merkez Bankasınca çeşitli düzenlemeler yapılmış, KKMH’ından elde edilen gelirler vergi beyannamesinden istisna tutulmuştur. Diğer taraftan 01.03.2022 tarihinde Kamu Gözetimi Muhasebe ve Denetim Standartları Kurumu
(KGK) tarafından “Döviz/Altın Dönüşümlü Kur/Fiyat Korumalı TL Mevduat Hesaplarının Muhasebeleştirilmesi Hakkında” duyuru yayınlanmıştır, Söz konusu bu duyuruda KKMH’nın bir finansal varlık olduğu , TFRS 9 Finansal Araçlar Standardı
kapsamında Gerçeğe Uygun Değer değişimi kar zarara yansıtılarak ölçümlenmesi gerektiği belirtilmektedir. Bu doğrultuda bağımsız denetime tabi bir şirketin vadeli döviz hesaplarının KKMH’na dönüştürmesi sonrasında ilgili mevduat
hesaplarının TFRS 9 kapsamında nasıl sınıflandırılacağı , dönem sonların nasıl ölçümleneceği ve oluşan gelir yada giderlerin nasıl muhasebeleştirilmesi gerektiği önem ihtiva etmektedir.
Logistics Performance Index And Its Sub-Components: Example of Turkey
Authors: KOYUNCU Günay
Published: May 2022

Ülkelerin lojistik performansını etkileyen ekonomik ve sosyal göstergeler birçok yazar tarafından incelenmiş ve tartışılmıştır. Küreselleşme, tüketicilerin e-ticaret üzerinden alışveriş talebinin artması, rekabet artışı, müşteri memnuniyeti,
gelişen teknolojiler, pandemi, maliyetler ve zaman kriteri Lojistik Performansının uluslararası ticaret üzerindeki önemini artırmıştır. Bu çalışmada, Türkiye’de Lojistik Performans Endeks (LPI) puanı ve LPI etkileyen alt bileşenler
incelenecektir. Türkiye’nin LPI incelendiğinde sahip olduğu en düşük alt bileşenin, gümrük değişkeninin olduğu görülmektedir. Ülkelerin gümrükleme sürecinin etkinliği hesaplanırken, gümrüklerde araçların bekleme süresi, gümrük
belge ve otomasyon süreleri, gümrük alt yapı sistemlerinin yeterliliği incelenmektedir. Çalışmanın son bölümde ise endeks puanının yükseltilebilmesi için Türkiye’de uygulanan yöntemler üzerinde durulacaktır. LPI hesaplamalarında
yer alan gümrük değişkeninin LPI’da yer alan puanının yükseltilebilmesi (gümrük işlemlerinin daha hızlı ve etkin yapılabilmesi) amacıyla T.C. Gümrük ve Ticaret Bakanlığı 21 Şubat 2020 yılında üç yeni uygulama gerçekleştirmiştir.
Bu uygulamalar İzinli Gönderici, İhracatta Yerinde Gümrükleme ve Yetkilendirilmiş Yükümlü Statüsüdür. Bu üç uygulamanın içeriği çalışmada açıklanacaktır.
The Examples of Mass Migration in the Republican Period and an Evaluation on Integration
Authors: GÖÇ Eray
Published: May 2022

The aim of this study is to evaluate Turkey, which has been exposed to many mass migration flows throughout the history of the Republic, and especially the immigrants accepted in the first years of the Republic, through some examples
in the context of mass migration and integration. In the period following the collapse of the Ottoman Empire, we see from the historical documents that the conflicts, especially in the lands under the Ottoman rule, reached the
peak, we also see that Turks and Muslims, who are former Ottoman citizens living in this geography, remained in the minority and were exposed to political assimilation policies. In this study, although the mass movements of the
Turkish or Muslim people who remained in the minority in the post-Ottoman Balkans or the movements of Muslim Turks were examined, the situation of the immigrants of Jewish origin from Germany was also evaluated. The treatment faced
by those who had to leave the regions they live in for various reasons in the regions they came from and what their effects were on this region were emphasized.
The Significance of Public Relations Practices During Organizational Communication Process in the Context of Grunig's "Theory of Excellence in Communication Management"
Authors: UZUN Gülcan
Published: May 2022

Günümüzde örgütler değişen ve gelişen topluma ayak uydurmak ve rakiplerinden ayrışmak için etkili bir iletişime ihtiyaç duymaktadır. Bir stratejik halkla ilişkiler faaliyeti olarak tanımlanan örgütsel iletişim süreci, kurumların hem
örgüt içi hem de örgüt dışı hedef kitleleri üzerinde olumlu etki oluşturmak ve var olan olumlu etkisini arttırmak amacıyla faaliyetlerini devam ettirdikleri süreçtir. Bu süreçte örgütlerdeki stratejik halkla ilişkiler faaliyetleri
göz önüne alınarak James Grunig’ in iletişim yönetiminde mükemmellik kuramı ön plana çıkmaktadır. Çalışmada, örgütsel iletişim sürecinde halkla ilişkiler uygulamalarının önemini ortaya koymak amaçlanmaktadır.
Effects Of Art Nouveau Art Movement On Glass And Ceramic Art
Authors: ASLAN Nuray , TEZCAN Hülya
Published: May 2022

Moda, insanlığın var olmasından bu yana kapanma ihtiyacını zaman içerisinde giyim tarzına yansıtarak, mekan ve zaman göre değişiklik göstermiştir. Bu düşünce tarzı geçmişten günüüze kadar uzanan ve modern çağın oluşturduğu gelişimler
ile her geçen gün farklılıklar göstererek yeni bir sektör halini almaktadır. Bu çalışmada Art Nouveau döneminde sanat akımının tekstil üzerine yansımaları araştırılmıştır. Çalışmaya moda ve tekstil sektörünün tarihi gelişimi ile
giriş yapılmış, ardından Art Nouveau akımının cam ve seramik Sanatına yansımalar ve mimariye etkileri incelenmiştir. Art Nouveau dönemin özellikleri ve sanatçıları araştırılmıştır. Mimari ve sanat çalışmaları üzerindeki etkileri
fazla olan Art Nouveau akımı, tekstil sektörü üzerinde de aynıyı etkiyi sahip olup olmadığı incelenmiştir. Bu kavramın literatür taramasını farklı kaynaklardan derleyip toparlayarak bilgilerini analiz edip, Art Nouveau Döneminde
Sanat Akımının Tekstil Üzerine Yansımalarını araştırmaktır. Bu çalışma bir anket çalışması olmadığı için evren ve örneklem söz konusu değildir.