bluuebunny/crossref_metadata_2025 huggingface dataset:
Interleukin-6 (IL-6) as a Marker of Endothelial Dysfunction Confirmed Using Flow Mediated Dilatation in Active Smoker
Authors: Wicaksono Arif , Kurnianingsih Novi , Tri Tjahjono Cholid , Widito Sasmojo , Yogibuana Swastika Putri Valerinna , Andri Wihastuti Titin
Published: January 2024

Background: The pro-inflammatory cytokine interleukin-6 (IL-6) is thought to be the catalyst for endothelial dysfunction caused by smoking. Flow-mediated dilatation (FMD) is a non-invasive method to identify the development of blood vessel endothelial dysfunction at an early stage. However, several studies have not sufficiently explained how smoking and IL-6 interact. Objective: This study focuses on the role of Interleukin-6 (IL-6) in the process of endothelial dysfunction confirmed using non-invasive modalities such as Flow Mediated Dilatation (FMD) in smokers related to the risk of cardiovascular disease in the future with the hope of providing insight in education to smokers to quit smoking. Material and Methods: In this study, we gathered 116 male participants, of which 56 were nonsmokers, and 60 were smokers, and we used IL-6 and FMD testing. SPSS for Windows version 23 will be used to analyze the data. Result: According to the analysis of laboratory tests, the average IL-6 level in light smokers was 67.7±3.2 and in moderate smokers it was 95.111.0; with a p-value of 0.009, indicating a significant difference among the groups. The average FMD in the smoking group was 5.4±0.4% (p-value 0.000), whereas the average FMD in the non-smoker samples was 10.9±0.9%. We also looked at the average FMD among light and moderate smokers based on Brinkman Index, which was 5.5±0.4% and 5.00.4%, with a p-value of 0.780, indicating no significant difference between the groups Conclusion: Compared to non-smokers, this study demonstrates a correlation between IL-6 and smoking activity. However, there was no statistically significant difference between the prevalence of endothelial dysfunction and the degree of smoking dependence in this investigation.
Gestión sostenible del agua y del suelo en la producción agropecuaria del departamento del Cesar
Authors: Ipaz Cuastumal Claudia Maricel , Tauta Muñoz José Luis , Calvo Salamanca Ana María , Ouazaa Sofiane , Terán Chaves César Augusto , Brochero Aldana Guillermo Alberto , Mojica Rodríguez José Edwin , Gómez Ramírez Luis Fernando , Burbano Erazo Esteban , Albonis Gómez Simón Andrés del Cristo , Rivera Rojas Milton , Garay Oyola Guillermo Antonio , Cordero Cordero Carina Cecilia , Sierra-Baquero Paola Vanessa , Fuentes Cassiani Deimer Alberto , Sánchez Doria Tatiana , Rubiano Rodríguez José Antonio , Martínez Reina Antonio María
Published: January 2024

Los resultados de investigación aquí consignados están dirigidos a productores, técnicos e interesados en los cultivos priorizados por el departamento del Cesar, y se presentan en siete capítulos: i) “Uso eficiente del suelo en sistemas de producción de forrajes y frutales en el Caribe seco”; ii) “Sistemas de riego por pivote central para la producción de biomasa a gran escala en el Caribe seco”; iii) “Producción, cosecha y poscosecha de cultivos forrajeros”; iv) “Eficiencia hídrica y productividad en dos sistemas silvopastoriles del Caribe seco colombiano”; v) “Manejo del agua y suelo, y control de plagas y enfermedades en el cultivo de mango Keitt en las condiciones del Caribe seco colombiano”; vi) “Manejo integrado del cultivo de cítricos en el Caribe seco: un enfoque en el uso eficiente del agua y el suelo, y el control efectivo de plagas y enfermedades”, y vii) “Análisis comparativo de los retornos económicos en los sistemas de producción priorizados entre la tecnología local y el uso del riego en el Centro de Investigación Motilonia de AGROSAVIA”.
Antropónimos-topónimos y las disputas sobre el territorio en la cuenca media del Usumacinta durante el periodo Clásico Temprano
Authors: García Juárez Sara Isabel
Published: January 2024

El presente artículo aborda el estudio de las formas de organización política maya durante el periodo Clásico Temprano en la cuenca media del Usumacinta a través del análisis epigráfico de los dinteles 60, 49, 37 y 35 de Yaxchilán. Derivado del estudio de estos cuatro monumentos, que forman una sola unidad narrativa, se explora la importancia de los antropónimos-topónimos en la reconstrucción histórica de procesos políticos, territoriales y sociales en la región. En dichos dinteles se encuentran registrados antropónimos-topónimos conformados por la expresión waklaju’un pet, ‘dieciséis pet[enes] (provincias)’, que son significativos por indicar, de manera indirecta, que algunas poblaciones estaban integradas por petenes (provincias), antes de que se consolidaran como “señoríos” (ajawlel). Los nombres de personas (antropónimos), que tienen integrados nombres de lugares (topónimos), aparecen en registros jeroglíficos de los periodos Clásico Tardío y Clásico Terminal y permiten dimensionar la profunda relación que existe entre los antropónimos, las designaciones de los territorios y los nombres de familia. Las evidencias más importantes que indican que la integración territorial de los señoríos, estructurados en “dieciséis provincias”, fue un fenómeno de larga duración (hasta el periodo Posclásico, en Mayapán) es la presencia de los términos waklaju’un oon, ‘dieciséis familias’ y waklaju’un ajaw, ‘dieciséis señores’, en las inscripciones del periodo Clásico, así como la evidencia de la existencia de dieciséis cuchcabaloob en Mayapán. La razón por la cual los mayas habrían concebido la estructura del ajawlel en dieciséis provincias – dieciséis familias habría respondido a una lógica armónica cuatripartita, direccional y cromática, con cuatro petenes en cada rumbo cósmico.
Haga su diagnóstico
Authors: Valdés Gómez Alejandra , Lanzarín Minero Abel Manuel , Ramírez-Arias José Luis
Published: January 2024

On this occasion we invite you to do the present exercise on the case of a 40 years old male patient, who has developed a progressive volume increase of the right testicle for the last 6 months, even did not report pain, but feeling of heaviness in the last week is present, ligth sign negative.
Las obras inacabadas de Rodin
Authors: Fortoul Teresa I.
Published: January 2024

Surprisingly, Rodin never studied at the School of Fine Arts and trained mainly self-
taught. This surely contributed to the development of a vision outside the canons of the Academy that changed reality to present it as pleasant, although false, far from reality. With his works he directed attention towards what was true, although imperfect, and in this he highlighted the beauty
Cardiovascular Disease Prediction Using Machine Learning Techniques
Authors: Singh Arin , Chaudhary Anjali , Chaudhary Dibyanshi , Vaish Yatharth , Tyagi Prof. Sachin
Published: January 2024

Abstract: The study examines the concerning increase in heart disease cases and emphasizes the importance of proactive forecasting. The timely and accurate detection of this growing health issue is essential. The main aim of the study is to determine whether a patient is at the risk of heart disease or not based on the dataset having the medical history of the patient. There are a number of linear and non-linear machine learning algorithms including Logistic Regression, K-nearest Neighbor, State Vector Machine and Random Forest Classifier which are used to determine the likelihood of having cardiovascular problems in the patient. The implementation of the algorithms such as Logistic Regression and Random Forest Classifier has shown the great results by providing a higher accuracy in predicting CVDs rather than the traditionally used methods such as Naive Bayes. The proposed method is not only cost effective but also is easier to use. It just requires some basic information of the patient and based on the feeded medical history of the patient , the results are produced. It improves the quality of the medical care as the patient can easily diagnose the possibility of having Cardiac diseases. This is helpful in preventing serious heart problems by providing an alarm to the patient at an early stage.
CRIAÇÃO DE HISTÓRIAS EM QUADRINHOS UTILIZANDO TECNOLOGIAS DIGITAIS: DIÁLOGOS POSSÍVEIS ENTRE FEMINISMO E EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA
Authors: Sousa Denise Francisca de , Bernardo Mirelle Amaral de São
Published: January 2024

O relato de experiência que se segue constitui um recorte da pesquisa de mestrado ProfEPT, Campus Ceres do IF Goiano, e descreve um dos principais procedimentos de intervenção: Curso de criação de histórias em quadrinhos (HQs). O objetivo geral era promover curso de criação de histórias em quadrinhos, a partir de tecnologias digitais e do tema gerador Feminismo, para estudantes do ensino médio integrado, numa perspectiva de formação crítica e integral. Foi desenvolvido de 01 de agosto a 06 de outubro de 2022, na plataforma Moodle IF Goiano, em quatro módulos teórico-práticos, com tutoria, encontros síncronos no Google Meet, carga horária total de 30 horas. Após abordagem da linguagem dos quadrinhos tradicionais, introdução a estudos feministas e feminismo nos quadrinhos, os estudantes produziram tirinhas e HQs completas em três ferramentas de desenvolvimento de narrativa on-line (Make Beliefs Comix, StoryboardThat e Pixton) e em um aplicativo para dispositivos móveis (Comica). Os resultados da pesquisa evidenciaram que o universo dos quadrinhos, principalmente da produção, contribuem para a formação crítica e integral dos estudantes, à medida que estes empregam a tecnologia de decodificação e codificação de seu “lugar de fala”, evidenciando e discutindo problemáticas sociais, como o Feminismo. Os efeitos da intervenção foram perceptíveis nos quadrinhos e nos excertos de atividades discursivas, produzidos pelos participantes - incluindo um estudante com transtorno do espectro autista (TEA), revelando “alfabetização” e apropriação da linguagem dos quadrinhos e, posterior, convergência destas para o ambiente digital.
CONSTRUINDO PROTOCOLOS PARA O ENSINO DE ANATOMIA VEGETAL ATRAVÉS DE PRÁTICAS LABORATORIAIS ACESSÍVEIS
Authors: Rocha Raquel Dalla Costa da , Edson-Chaves Bruno , Rodrigues Ana Claudia , Oliveira Fernanda Maria Cordeiro de
Published: January 2024

Uma das preocupações dos professores no ensino de ciências são as dificuldades no processo de ensino-aprendizagem resultantes, em partes de indisponibilidade de estrutura física e material. Particularmente, os conteúdos de anatomia vegetal são menos atrativos, devido à ausência de laminário e laboratórios equipados com microscópios. O presente trabalho teve como objetivo propor protocolos da preparação de lâminas histológicas com materiais alternativos e acessíveis, para observação das estruturas vegetais por meio de um microscópio artesanal. Para os protocolos foram utilizados materiais vegetais de fácil acesso e corantes alternativos encontrados em farmácia. As imagens anatômicas foram obtidas através do microscópio artesanal com uma câmera de celular acoplada, visando demonstrar sua qualidade e efetividade de uso. O uso das lâminas histológicas em sala de aula proporciona aprendizagem atrativa e motivadora, contribuindo para uma compreensão dos conteúdos mais complexos, possibilitando a minimização da Impercepção Botânica. Esta abordagem vem crescendo no ambiente educacional. Alternativas simples e de baixo custo oferecem uma ótima interação do professor com os alunos além da compreensão e proximidade destes com conteúdo que envolvem estruturas vegetais e botânica.
Spatial Closeness of Population and Economic Growth
Authors: Bürgi Constantin , Gorgulu Nisan
Published: January 2024

We look at the spatial angle of economic growth. Specifically, we assess whether areas where people live closer together experience faster growth. Traditional measures like population density or urbanization are not optimal, as they are affected by large uninhabited areas or capped, respectively. We thus introduce a new measure Spatial Population Concentration (SPC) that captures how many people live on average within a given radius of every person within a geographic area. This measure allows for a more accurate measurement of the population concentration than traditional measures, as it does not share some of their shortcomings. Next, we show for U.S. counties that areas with a high spatial population concentration experience faster growth. We nd that counties with a low value of SPC measure in 1990 experienced substantially lower GDP growth over the next 25 years.
Manuka Honey as an Adjunct to Nonsurgical Periodontal Treatment: A Pilot Study
Authors: Safii Syarida Hasnur , J. Medlicott Natalie , J. Milne Trudy , J. Duncan Warwick
Published: January 2024

This pilot study evaluated the effect of manuka honey as a subgingival adjunct to scaling and root surface debridement in the treatment of periodontitis. This study used a split-mouth design with a 3-month follow-up in seven participants diagnosed with periodontitis Stage III Grade B or C. Root surface debridement was performed on one side of the mouth (control); the other side received debridement plus manuka honey application (test). Clinical parameters were recorded at baseline, 6- and 12-weeks. Gingival crevicular fluid and subgingival plaque were sampled. Microbiological outcomes were analysed using benzoylarginine p-nitroanilide assay and polymerase chain reaction assays. Single application of manuka honey to periodontal pockets did not result in additional reduction of pocket depth, improvement of attachment levels or changes in p-nitroaniline enzymes when compared with root surface debridement alone. However, test sites exhibited greater reduction in bleeding than control sites, mean differences 1.3 (95%CI 1.2-1.5) and 1.7 (95%CI 1.5-1.9) at 6-weeks and 12-weeks, respectively. The proportion of mutans streptococci decreased at 6-weeks in test sites but increased at 12-weeks in control sites. Adjunctive application of manuka honey to periodontal pockets improved gingival inflammation but did not demonstrate significant clinical benefits compared with root surface debridement alone.
Filosofía de las ciencias sociales y las humanidades
Authors: Monroy Gutiérrez Einar Iván
Published: January 2024

ste capítulo se propone formular los cuatro cimientos teórico-epistemológicos para el Doctorado en Ciencias Sociales y Humanidades de la UNAD. En primer lugar, en ontología relacional y lógica del campo, contra una ontología de la sustancia, se sostiene que ser significa ser-en-relación o, dicho de otro modo, que nada es sin relación; contra una lógica de oposiciones sustanciales, A y no-A, se da un tercer elemento o campo de fuerzas. En segundo lugar, en la espacio-historicidad del ser humano se comprende que la espacialidad –no espaciosidad– es el comportamiento del ser humano consigo mismo, con los otros y con las cosas que comparecen en su mundo, dejándoles ser como tales otros y cosas, abriéndoles un espacio, dándoles un sentido, valor, uso en un plexo de relaciones y lugares; la historicidad hace refe-rencia a la índole «aconteciente» de la existencia humana, a la movilidad de la trama de la vida humana que se extiende entre el nacimiento y la muerte, a la apropiación de la tradición y el destinarse de un individuo o una comunidad. En consecuencia, se tiene la exigencia de un enfoque sistémico, según el cual ningún ente, aconteci-miento o individuo, ningún fenómeno al que se le mire en términos teóricos es una mónada aislada o desvinculada, sino que lo que se da se desoculta, aparece dentro de un sistema complejo, en un plexo de relaciones con otros objetos, tanto «inter-nos» como «externos». No solo busca superar la visión de un mundo mecanicista y fragmentario, sino comprenderlo en su complejidad, lo que demanda ejercicios de reflexión, investigación, construcción de conocimiento, creación, innovación y transformación más allá de las fronteras disciplinares y mediante procesos intra, inter y transdiciplinarios. Consecuencia de lo anterior es la exigencia de una ciencia posnormal en la que, además de la superación de la disyunción sujeto/objeto, es necesario superar la consideración de las teorías como un calco de la realidad y re-flexionar sobre el papel de la ciencia en la sociedad, partiendo del supuesto de que el modo y los principios con los cuales la ciencia normal ha operado en la resolución de problemas ya no es suficiente para enfrentar los problemas actuales.
Métodos cromatográficos especiais para a análise de líquido ruminal, silagem e leite em ruminantes
Authors: Castillo Vargas Julián Andrés , Costa de Araújo Tiago , Duarte Gomes Silva Botelho , Pereira Maciel Raylon , Mezzomo Rafael
Published: January 2024

A busca continua pela maximizacao da producao de ruminantes e pela reducao de seus efeitos negativos no meio ambiente tem estimulado, nos ultimos anos, o desenvolvimento e implementacao de diversas estrategias nutricionais e de alimentacao animal. Produto desta otimizacao, obtiveram-se melhorias consideraveis, em termos de maior eficiencia produtiva e qualidade composicional dos produtos derivados de ruminantes. Essas tendencias de “produzir mais com menos”, “produzir limpamente” e de “melhorar a qualidade nutricional” dos produtos derivados da producao de ruminantes tem exigido, nos ultimos anos, maior intensidade na transdisciplinaridade. Isso implica que as ciencias agrarias estao constantemente buscando apoio em ciencias afins, como as ciencias basicas, incluindo quimica, biologia, geologia, estatistica, matematica e farmacia. Particularmente no caso das ciencias quimicas, estas fornecem ferramentas fundamentais na nutricao animal, para a tomada de decisoes, do ponto de vista do conhecimento da composicao de alimentos (por exemplo: forrageiras, concentrados, subprodutos etc.), tecidos (exemplo: orgaos, musculos e ossos) e produtos derivados (exemplo: leite, carne e outros produtos alimenticios) de ruminantes. Assim, a quimica tem o potencial de apoiar tanto o elo primario quanto os subsequentes na cadeia de producao pecuaria. Em particular, a quimica analitica instrumental fornece ferramentas para entender o impacto das estrategias nutricionais adotadas ou mesmo as caracteristicas do ruminante, no seu metabolismo de nutrientes e como isso influencia na qualidade de seus produtos. Nesse sentido, os metodos instrumentais modernos, mais especialmente os metodos cromatograficos e espectroscopicos, fornecem informacoes em termos da abundancia e presenca de compostos organicos de interesse, visando a producao de alimentos de melhor qualidade com menor custo ou impacto ambiental. No entanto, livros especificos propondo o uso de tecnicas cromatograficas acopladas as espectroscopicas no campo da producao animal sao escassos e, por vez, ausentes. Desta forma, com esta publicacao pretende-se fornecer um conjunto de ferramentas atraves da utilizacao de metodos quimico-instrumentais focados na combinacao de tecnicas cromatograficas e espectroscopicas, que procuram fornecer ferramentas de diagnostico para otimizar a producao de ruminantes. O material propoe diversas metodologias para a analise de metabolitos de interesse para a producao animal em liquido ruminal e leite de ruminantes, bem como em silagem, para esta especie.
Extração, identificação e quantificação de ácidos graxos voláteis (AGV) em amostras de fluido ruminal usando cromatografia líquida de alta eficiência em fase reversa acoplada a detetor de arranjo de diodos (RP-HPLC-DAD)
Authors: Castillo Vargas Julián Andrés , Costa de Araújo Tiago , Mezzomo Rafael
Published: January 2024

Em animais ruminantes, os ácidos graxos voláteis (AGVs) ou ácidos graxos de cadeia curta (AGCCs) são derivados da fermentação de proteínas e carboidratos pelo microrganismo ruminal. Assim, a determinação de AGV no líquido ruminal permite avaliar a qualidade nutricional de uma dieta, bem como seu potencial impacto na composição química do leite e da carne de ruminantes. Desta forma, no presente capítulo, apresenta-se um protocolo para extrair, identificar e quantificar os principais AGVs no líquido ruminal, utilizando a técnica de cromatografia líquida em fase reversa acopla-da a detector de arranjo de diodos (RP-HPLC-DAD). O método envolve a extração líquido-líquido de AGVs em líquido ruminal usando ácido fosfórico 0,85% m/m, cujo extrato é analisado por RP-HPLC-DAD após microfiltração. Os AGVs são quantificados pelo método de padrão externo.
Extração, identificação e quantificação de proteínas do leite bubalino usando a combinação de cromatografia líquida de alta eficiência de fase reversa (RP-HPLC) e medidas de espectroscopia no infravermelho próximo (NIRS)
Authors: Castillo Vargas Julián Andrés , Costa de Araújo Tiago , Botelho Duarte Gomes Vinícius da Silva , Pereira Maciel Raylon
Published: January 2024

O desenvolvimento de novos métodos para estimar o número de variantes proteicas de caseína (CN) e proteínas no soro do leite de búfala é necessário para otimizar as propriedades tecnológicas e nutricionais dos derivados lácteos desta espécie. Desta forma, no presente capítulo, propõe-se um método para quantificar as principais variantes proteicas da caseína e as principais proteínas no soro do leite de búfalas, utilizando a combinação de medidas derivadas das técnicas de cromatografia líquida de alta eficiência de fase reversa (RP-HPLC) e medidas de espectroscopia no infraver-melho próximo (NIRS). O método envolve uma extração líquido-líquido sequencial das frações proteicas usando solução tampão de BisTris, cloridrato de guanidina, citrato de sódio e dl-ditiotreitol. O extrato final obtido deve ser analisado por RP-HPLC-DAD, usando-se o valor de caseína e proteína totais obtido por NIRS para a quantificação das proteínas separadas e identificadas
Exploring the miRNA-mediated response to combined stress conditions in melon plants.
Authors: Villalba-vermell Pascual , Marquez-Molins Joan , Marques-Romero Maria Carmen , Hernandez-Azurdia Andrea , Sierra Julia Corell , Pico-Sirvent Maria Belen , Monforte Antonio , Elena Santiago , Gomez Gustavo
Published: January 2024

Climate change has been associated with a higher incidence of combined
adverse environmental conditions that can promote a significant decrease
in crop productivity. However, knowledge on how a combination of
stresses might affect plant development is still scarce. MicroRNAs
(miRNAs) have been proposed as potential targets for improving
crop-productivity. Here, we have combined deep-sequencing, computational
characterization of responsive miRNAs and validation of their regulatory
role in a comprehensive analysis of melon’s response to several
combinations of four stresses (cold, salinity, short day, and infection
with a fungus). Twenty-two miRNA families responding to double and/or
triple stresses were identified. The regulatory role of the
differentially expressed miRNAs was validated by quantitative
measurements of the expression of the corresponding target genes. A high
proportion (ca. 60%) of these families (mainly highly conserved miRNAs
targeting transcription factors) showed a non-additive response to
multiple stresses in comparison with that observed under each one of the
stresses individually. Among those miRNAs showing non-additive response
to stress-combinations, most interactions were negative suggesting the
existence of functional convergence in the miRNA-mediated response to
combined stresses. Taken together, our results provide compelling
evidences that the response to combined stresses cannot be easily
predicted from the study individual stresses.
Passivity-based Stability Analysis of Power Networks with Uncertain Interconnections
Authors: Kookhdan Narges Rezaei , Koofigar Hamid Reza
Published: January 2024

In this paper, a network stability analysis algorithm is proposed for
the uncertain interconnected systems. To reduce the complexity of
analysis, compositional certification strategy is adopted, i.e., instead
of studying the characteristics of the whole network, the property of
subsystems is assessed. The proposed method firstly analyzes a
dissipative property of subsystems of the interconnected system. Then,
by taking the uncertainty of interconnections into account, a
compositional stability criterion is given for stability analysis of the
network. Compared with some previous investigations, the presented
algorithm has less computation burden, which facilitates the application
to large-scale interconnected power systems. Numerical analysis confirms
the proposed method can assess the stability of an IEEE 14-bus test
system, in the presence of uncertainties.
Elevated procalcitonin levels in prostate cancer
Authors: Çalışkan Selahattin , Ilktac Abdullah , Kalkan Senad
Published: January 2024

This article is reply to the letter to the editor
Climate change and resistant varieties mediate a critical transition in the coffee rust disease
Authors: Li Kevin , Hajian-Forooshani Zachary , Su Chenyang , Perfecto Ivette , Vandermeer John
Published: January 2024

Critical transitions, sudden responses to slow changes in environmental
drivers, are inherent in many dynamic processes, prompting a search for
early warning signals. We apply this framework to understanding the
coffee rust disease, which experienced an unprecedented outbreak in
Mesoamerica in 2012-2013, likely a critical transition. Based on monthly
infection data from 128 study quadrats in a 45-ha plot in southern
Mexico from 2014 to 2020, we find that the persistent seasonal epidemic
following the initial outbreak collapses in an evident subsequent
critical transition. Characteristic signals of “critical slowing down”
precede this collapse and are correlated with reduced rainfall, as
expected from climate change, and planting of rust-resistant varieties,
an ongoing management intervention. Recoveries from catastrophes may
themselves be experienced as a critical transition and managers should
consider the larger dynamical landscape for the possibility of
subsequent transitions. Early warning signals could therefore be useful
when evaluating mitigation effectiveness.
Identified and Characteristics Analysis of Drug-related Problems: Pharmaceutical Care to Cardiovascular Patients in china
Authors: Guo Xiaoyi , Li Jianchun , Guo Jianman , Zhao Lixia , Liu Anchang
Published: January 2024

Aim: Cardiovascular patients have a high risk for Drug-related
problems(DRPs) , howevre studies the prevalence and risk factor for
these patients in china are still unkown.This study was conducted to
identify characteristics and risk factors associated with DRPs of
cardiovascular patients in China, and assess the effectiveness of
pharmaceutical practice. Methods:This was a retrospective study in a
cardiology department of an academic teaching hospital for 12 months. A
total of 1729 patients were enrolled. Pharmaceutical care was
implemented by a pharmacy team. Drug-related problems were categorized
by the Pharmaceutical Care Network Europe(PCNE) classification V9.1.
Main outcome measure were the prevalence, characteristics and risk
factors of drug-related problems. Results: During this study, 203 DRPs
were found in 152(8.8%) patients,204 intervention, the success rate of
intervention was 99.0%. Hospitalized days ≥ 8.5(OR=1.925,95%
CI:1.363-2.717) had a better sensitivity and specificity in predicting
the occurrence of drug-related problems, compared with patient age and
number of concomitant diseases. The most common type of drug-related
problems was “Effect of drug treatment not optimal”( 34.5%) ,
“patient transfer related” was the primary cause of drug-related
problems (35.3%). Among the top medications associated with
drug-related problems were Auxiliary medications (20.2%) followed by
antianginal medications (17.2%) , Antiplatelet agents (11.8%), and
β-Adrenergic receptor antagonists (11.8%). Conclusion: Drug-related
problems are relatively common in hospitalized cardiovascular patients
in China, “patient transfer related” is the primary cause and
“Hospitalized days” is the major risk factors for these patients.
Pharmacist intervention can identify and resolve pertinent drug-related
problems to optimize medication therapy.
Prevalence of Migraine Headaches and their Impact on the Academic performance of Medical Campus Students at University of Khartoum using ID-Migraine test as a screening tool: A cross-sectional study from Sudan
Authors: MOHAMEDOSMAN MOAID MOHAMEDOSMAN ALI , Ahmed Khabab Abbasher Hussien Mohamed , Omer Mohammed
Published: January 2024

Background Migraine — an episodic headache —is one of the most
common types of primary Headache. Migraine is considered a serious
health problem that affects the quality of life. During university life,
students often report increased levels of stress, depression, anxiety,
and irregular sleep, all of which are associated with migraines.Our aim
was to determine the prevalence of migraine headaches among medical
campus students at university of Khartoum, Sudan. Based on available
data, migraine is on the rise in both general populations as well as
university students. Methods In this cross-sectional and descriptive
study, study population was composed of students registered to faculty
of medicine, Dentistry and pharmacy at Khartoum University in the
academic years of 2020-2021. Out of these 318 of them accepted to
participate. Participants who had two or more headaches in the last 3
months formed the headache group. Afterwards, two preliminary questions
were applied to the headache group and participants with at least one
affirmative response were asked to perform the validated ID-Migraine™
test. Results The mean age of 318 students participated in the study was
19.23 ± 1.84 (17-39 years), with adolescents: adult ratio being 2.5:1.
1613 students (43.7%) did have at least two headaches in the last three
months. Migraine-type headache was detected in 266 subjects (7.2%)
based on the ID-Migraine™ test. Of the migraine group, 72 were male
(27.1%) and 194 were female (72.9%). There was no significant
difference in migraine prevalence between adolescent and adult age
groups. Conclusions With prevalence similar to adults, primary care
physicians should be aware of the probability of migraine headaches in
university students in order to maintain a successful school
performance.
Characteristics of equiform-Bishop Hasimoto surfaces in Minkowski 3-space
Authors: Solouma Emad , AL-Dayel Ibrahim
Published: January 2024

We investigate the equiform-Bishop Hasimoto surfaces
℘(\sigma, t) in Minkowski 3-space in this paper. In
E^3_1, in different three cases, the geometric properties of
equiform-Bishop Hasimoto surfaces are discussed. For each case, the
equiformBishop Gaussian and mean curvatures of the equiform-Bishop
Hasimoto surface are determined. Then, in E^3_1, we characterize the
parameter equiform Bishop curves of equiform-Bishop Hasimoto surfaces.
Do the evolutionary interactions between moths and bats promote niche partitioning between bats and birds?
Authors: Bullington Lorinda , Seidensticker Mathew , Schwab Nathan , Ramsey Philip , Stone Kate
Published: January 2024

Ecological theory suggests that the coexistence of species is promoted
by the partitioning of available resources, as in dietary niche
partitioning where predators partitioning prey. Yet, the mechanisms
underlying dietary niche partitioning are not always clear. We used
fecal DNA barcoding to investigate diets of seven nocturnal
insectivorous bird and bat species. Low diet overlap (2-22%) supported
resource partitioning among all species. Differences in diet
corresponded with species identity, prey detection method, and foraging
behavior of predators. Insects with ultrasonic hearing capabilities were
consumed significantly more often by birds than by bats, consistent with
an evolved avoidance of echolocating strategies. In turn, bats consumed
a greater proportion of non-eared insects such as spruce budworm.
Overall, our results suggest that evolutionary interactions among bats
and moths translate to dietary niche partitioning and coexistence among
bats and nocturnal birds.
Non-anastomotic vascular graft rupture detected by non-obstructive aortic angioscopy: a case report
Authors: Yamana Fumio , Maeda Koichi , Shirakawa Yukitoshi , Masai Takafumi
Published: January 2024

Non-anastomotic graft rupture in contemporary vascular prostheses is
extremely rare and difficult to diagnose. We report a case of
non-anastomotic vascular graft rupture diagnosed using non-obstructive
aortic angioscopy. An 85-year-old male who underwent total arch
replacement five years prior presented to our institution with chest
pain. Based on contrast-enhanced angio-computed tomography and aortic
angiography, we suspected extravasation of the thoracic vascular graft.
Assessment of the vascular graft of the ascending aorta using aortic
angioscopy revealed a red vascular graft defect. Non-anastomotic graft
rupture was diagnosed by aortic angioscopy. The patient underwent
2-debranching thoracic endovascular aortic repair (Zone 0) with right
subclavian artery-left common carotid artery-left subclavian artery
bypass. Completion angiography and postoperative computed tomography
showed the disappearance of the extravasation. Aortic angioscopy can
help reach a definitive diagnosis in patients with graft rupture.
Vitamin D as an adjuvant therapy in Neonatal Bronchopulmonary Dysplasia: is it beneficial?
Authors: Elfarargy Mohamed , Al-Ashmawy Ghada
Published: January 2024

Background: Neonatal bronchopulmonary dysplasia (BPD) is a chronic
neonatal respiratory disease that is caused by prolonged oxygenation and
mechanical ventilation (MV), leading to respiratory distress (RD).
Patients and methods: Prospective randomized controlled trial (RCT) with
identification number TCTR20210622001 which was done at Tanta University
Hospital (TUH) from August 2016 to February 2018 on 100 premature
neonates who had RD and were put on MV. The examined neonates were
classified into 2 groups: group 1, which received vitamin D
supplementation, and group 2, which had placebo. Urinary
β2-microglobulin (B2M) in addition to serum Krebs von den Lungen-6
(KL-6) levels were measured on the 1st and the14th day of
hospitalization. Results: Significant decrease in urinary B2M and serum
KL-6 levels in neonates of group 1 who were received vitamin D, if
compared with group 2 neonates, who had taken placebo (P <
0.05). There was a significant decrease in the time of hospital stay in
group 1 neonates, if compared with group 2 neonates (P <
0.05). Group 1 neonates showed a significant decrease of the developed
BPD cases, if compared with group 2 (P < 0.05). Conclusion:
Vitamin D supplementation may help in the prevention of BPD in neonates.
Recommendation: Routine vitamin D supplementation to preterm neonates
who are susceptible to develop BPD.
Simultaneous changes of PD-1、PD-L1、CTLA-4、TGF-β1、HIF-1α、IL-2、IL-6 in peripheral blood of chemothepy-SCLC and their relation with clinical characteristics and survival
Authors: yang jihua , jiao shunchang , wen juyi , zheng wei
Published: January 2024

This study was the first to report the prognostic value of PD-1, PD-L1,
CTLA-4, TGF-β1, HIF-1α, IL-2 and IL-6 in peripheral blood on PFS and OS
of SCLC.Few studies had reported the correlation between immune-related
factors and SCLC survival in SCLC studies, while no studies had reported
more than 7 immune-related factors at the same time.We investigated the
changes of IL-2, IL-6, TGF-β1, HIF-1α, PD-1, PD-L1 and CTLA-4 in the
course of chemotherapy compared with healthy controls, the relationships
between each factor and clinical characteristics, the relationships
among the 7 factors, and the relationships between the 7 factors and
survival，prognosis.There were statistical differences in 7 cytokines
between SCLC patients and healthy controls before and during treatment
metagenomic next-generation sequencing in the diagnosis of deep sternal wound infection after cardiac transplantation: a case report and literature review
Authors: Yu Jiongbiao , Wu Rongjie , Xiong Bing , Li Hanhua
Published: January 2024

Purpose: To explore the value of metagenomics next-generation sequencing
(mNGS) for deep sternal wound infection (DSWI) diagnosis Method: The
mNGS was used to diagnose the DSWI after cardiac transplantation and
guide the antibiotics prescription Results: The co-infection of
methicillin-resistant Staphylococcus aureus (MRSA) and cytomegalovirus
(CMV) was detected in this patient. The infection was controlled and the
wound healed successfully with the specific medicine based on mNGS
results for three weeks. Conclusion: The mNGS is effective to achieve
precise, individualized, and rapid treatment for wound infection
Prediction of IBNR and RBNS Liabilities using Estimated Delay Probabilities by a Zero-Inflated Gamma Mixture Model
Authors: Atatalab Fatemeh , Payandeh Amir
Published: January 2024

This article considers the problem of predicting the amount/number of
claims that have been incurred but not reported, say IBNR, and reported
but not settled, say RBNS. Using the delay probabilities, calculated by
the ZIGM distribution, it predicts both IBNR’s and RBNS’ loss reserves
and the corresponding mean square error. The practical application of
our findings are applied against a real data.
Fan-Gottesman Compactification and Completion of Pre-Uniform Space
Authors: Elmalı Ceren , UĞUR Tamer
Published: January 2024

we show that there exists a homeomorphism f between X^* Fan-Gottesman
compactification of T_3-topological space (X,τ) and the canonical
extension (X~̵̂,(U(β) )~̵̂ ) of the pre-uniform space (X,U(β)). Therefore we
also showed that X^* Fan-Gottesman compactification T_3-topological
space (X,τ) can be viewed as the completion of certain pre-uniform space
(X,U(β)).
An Assessment of Anxiety About the Viral Epidemic and Work-Related Stress in Family Physicians in Turkey: How does COVID-19 Vaccination Affect Anxiety and Stress?
Authors: Acar Aysima Bulca , Eke Remziye Nur , Özen Mehmet
Published: January 2024

Objective: The present study aimed to evaluate the extent of family
physicians’ anxiety about the viral epidemic and work-related stress
associated with the viral epidemic as well as examining the effects of
COVID-19 vaccination on such situations. Methods: The data collection
forms, including SAVE-9 scale in order to assessand examine the extent
of anxiety and stress, prepared for this cross-sectional study were
converted into an online questionnaire form and sent to the physicians
working as family physicians in different provinces of Turkey between
December 2020 - March 2021 via e-mails and communication groups. The
responses of 500 family physicians, who were accessible through this
method and volunteered to participate in the study, were recorded to be
analysed. Results: Of all the 500 family physicians in this study,
40.6% of them were found to be in a state of anxiety about the viral
epidemic. While there was a significant decline in the scores of anxiety
about the viral epidemic in the subgroup after vaccination, there was no
statistically significant change in work-related stress scores.
Conclusion: Family physicians have been suffering anxiety due to the
pandemic. The vaccination has a positive impact on anxiety.
Mutational Analysis of Interleukin-11 and its Consequences on Cancer and COVID-19 Related Cytokine Storm -An Extensive Molecular Dynamics Study
Authors: Luhuraka Shreya , Ray Sujay
Published: January 2024

Interleukin-11 is a pleiotropic cytokine that is known to play an
important role in the progression of various forms of cancer by
modulating the survival and proliferation of tumour cells. IL11 also
demonstrates a structural homology to IL6 - the predominant cytokine
involved in COVID-19. This makes IL11 a potential therapeutic target in
both diseases. This study aimed to evaluate the impact of two mutations-
R135E and R190E on the stability of IL11. Any changes in the interaction
of IL11 with its receptor IL11Rα, induced by the two mutations were also
determined with the help of techniques such as molecular modelling,
molecular docking, and molecular dynamics simulations. Our analysis
revealed that the two mutations cause a small decrease in the overall
stability of IL11, which was evident by the increased atomic
fluctuations in the mutated regions. Moreover, mutation R135E led to an
increase in the binding affinity of IL11 with IL11Rα and the formation
of a more stable complex in comparison to the wild-type protein and its
receptor. Mutation R190E led to the formation of a less stable complex
than the wild-type which suggests a decrease in the binding affinity
between IL11 and IL11Rα.
Effect of Sodium Tungstate on Anaerobic Digestion of Waste Sewage Sludge: Enhanced Methane Production via Increased Acetoclastic Methanogens
Authors: Roy Chapol , Toya Shotaro , Hoshiko Yuki , Sabidi Sarah , Mustapha Nurul Asyifah , MAEDA Toshinari
Published: January 2024

In this study, the effect of sodium tungstate on aerobic digestion of
waste sewage sludge (WSS) was investigated. Interestingly, enhanced
methane production was found according to the increased concentration of
sodium tungstate to WSS. Acidogenesis stage was influenced by sodium
tungstate because the amount of acetate decreased whereas that of
isobutyrate increased during the anaerobic digestion of WSS supplemented
with sodium tungstate. Since acetate consumed with time during the
anaerobic digestion of WSS, the pH of WSS increased in the presence of
sodium tungstate. The analyses of methanogenesis via acetoclastic and
hydrogentrophic methanogens indicate that methane production from
acetate was high in the WSS with sodium tungstate. In addition, the
addition of sodium tungstate to the initial fresh WSS did not enhance
methane production from acetate; therefore, sodium tungstate may
increase the number of acetoclastic methanogens rather than promote the
catalytic reaction related to the methane production. The analyses of
archaeal population supported that acetoclastic methanogens (mostly
Methanosaeta) increased from 3.02% to 31.20% in the presence of sodium
tungstate. Furthermore, the addition of sodium tungstate enhanced the
growth of Methanosarcina acetivorans C2A. Taken together, sodium
tungstate increases methane production via the anaerobic digestion of
WSS by increasing the activity of acetoclastic methanogenesis.
Enhancement of the immunogenicity of a Mycobacterium tuberculosis fusion protein using ISCOMATRIX and PLUSCOM nano-adjuvants after nasal administration in mice
Authors: Avarvand Arshid Yousefi , Meshkat Zahra , Khademi Farzad , Aryan Ehsan , Sankian Mojtaba , Tafaghodi Mohsen
Published: January 2024

Background: Tuberculosis (TB), a contagious disease caused by
Mycobacterium tuberculosis (M. tuberculosis), remains a health problem
worldwide and this infection has the highest mortality rate among
bacterial infections. Current studies suggest that intranasal
administration of new tuberculosis vaccines could enhance the
immunogenicity of M. tuberculosis antigens. Hence, we aim to evaluate
the protective efficacy and immunogenicity of HspX/EsxS fusion protein
of M. tuberculosis along with ISCOMATRIX and PLUSCOM nano-adjuvants and
MPLA through the intranasal administration in mice model. Methods: in
present study, the recombinant fusion protein was expressed in
Escherichia coli and purified and used to prepare different nanoparticle
formulations in combination with ISCOMATRIX and PLUSCOM nano-adjuvants
and MPLA. Mice were intranasally vaccinated with each formulation three
times at an interval of 2 weeks. Three weeks after final vaccination,
IFN-γ, IL-4. IL-17 and TGF-β concentration in supernatant of cultured
splenocytes of vaccinated mice as well as serum titers of IgG1 and IgG2a
and sIgA titers in nasal lavagewere determined. Results: According to
obtained results, intranasally vaccinated mice with formulations
containing ISCOMATRIX and PLUSCOM nano-adjuvants and MPLA could
effectively induced IFN-γ and sIgA responses. Moreover, both
HspX/EsxS/ISCOMATRIX/MPLA and HspX/EsxS/PLUSCOM/MPLA and their BCG
booster formulation could strongly stimulate the immune system and
enhance the immunogenicity of M. tuberculosis antigens. Conclusion: The
results demonstrate the potential of HspX/EsxS-fused protein in
combination with ISCOMATRIX, PLUSCOM and MPLA after nasal administration
in enhancing immune response against of M. tuberculosis antigens. Both
nanoparticles were good adjuvants in order to promote immunogenicity of
TB fused antigen. so, nasal immunization with these formulations, could
induce immune responses and considered as new TB vaccine or as BCG
booster.
Promoting expression of IP-10 and chemotaxis of γδT cells by silencing CNOT7 of HepG2 cells in vitro
Authors: Tian Wei , Lin Qixiong , MENG YANFENG , XU CAIXIA , WEN YANYAN , HE JIEFENG , Zhao Haoliang
Published: January 2024

CCR4-NOT transcription complex, subunit 7(CNOT7) serving as the
predominant deadenylase in all eukaryotes, has great function in
regulating transcription and mRNA degradation, and it has been shown to
correlate with poor prognosis in the tissues of Hepatocellular
carcinoma. Silencing the CNOT7 gene can up-regulate the expression of
the subset of STAT1 regulatory genes with its downstream chemokine IP-10
through enhancing the occupation of the basic promoter of STAT1 .In
peripheral blood circulation, the immune cells γδT could be induced to
migrate to the specific areas through the chemokine receptor CXCR3 which
presents in γδT , bind with the chemokine IP-10.Based on this basic , we
hypothesize that silencing the CNOT7 gene in HCC cells could induce the
directional homing of immune cells γδT to cancer tissues to exert an
anti-tumor effect through up-regulating the expression of local STAT1
and IP-10. To verify the hypothesis, we designed an experiment about the
CNOT7 gene silenced in HepG2 cell line in vitro, and then we analyzed
the expression of STAT1, IP-10, and the expression of CXCR3 in γδT cells
after being amplified. Besides, we also analyzed the effect of the
expression product of STAT1, pSTAT1, IP-10 and CXCR3 on γδT chemotactic
ability. In conclusion, our results suggest that the expression of IP-10
and chemotaxis of γδT cells could be up-regulated by silencing CNOT7 of
HepG2 cells in vitro.
Ocean & seas: Novel biomedical resources for anti-infection of SARS-CoV-2
Authors: Hu Chunsong
Published: January 2024

This article briefly reviews ocean and seas as huge and novel biomedical
resources for anti-infection, which includes tuberculosis, H. Pylori,
and HIV infection as well as SARS-CoV-2, and as promising biomedical
resources for infection-induced major non-communicable diseases (mNCDs),
such as cardiovascular disease, diabetes, and cancer. These marine
natural products (MNPs) and organisms include sea cucumbers, sea snake,
sponge, marine algae and microalgae, etc. As key biomedical resources
for the discovery of marine drugs, bioactive molecules, and agents for
treatment of infectious diseases and mNCDs, MNPs have bioactive
potentials of antioxidant, anti-infection, anti-inflammatory,
anticoagulant, anti-diabetic effects, and cancer treatment. In addition,
their anti-inflammatory mechanisms for infectious diseases are also
involved. It’s time to protect ocean ecosystem for human better
sustainable development in the new era of ocean economy.