bluuebunny/crossref_metadata_2025 huggingface dataset:
A Differential Protein Study on Bronchoalveolar Lavage Fluid at Different
Stages of Silicosis
Authors: Zhang Xiaoxuan , Han Ke , Kan Linhui , Zhang Zheng , Gong Yihong , Xiao Shuyu , Bai Yuping , Liu Nan , Meng Chunyan , Qi Huisheng , Shen Fuhai
Published: January 2024

Objectives:

In this study, by comparing the difference in protein expression in bronchoalveolar lavage fluid between silicosis patients in different stages and healthy controls, the
pathogenesis of pneumoconiosis was discussed, and a new idea for the prevention and treatment
of pneumoconiosis was provided.

Methods:

The lung lavage fluid was pretreated by 10 K ultrafiltration tube, Agilent 1100 conventional liquid phase separation, strong cation exchange column (SCX) HPLC pre-separation, and
C18 reverse phase chromatography desalting purification, and protein was labeled with isotope.
GO, KEGG pathway, and PPI analysis of differential proteins were conducted by bioinformatics,
and protein types and corresponding signal pathways were obtained.

Results:

Thermo Q-Exactive mass spectrometry identified 943 proteins. T-test analysis was used
to evaluate the different significance of the results, and the different protein of each group was
obtained by screening with the Ratio≥1.2 or Ratio≤0.83 and P<0.05. We found that there are 16
kinds of protein throughout the process of silicosis. There are different expressions of protein in
stages Ⅲ/control, stages Ⅱ/control, stage Ⅰ/control, stages Ⅲ/ stages Ⅱ, stages Ⅲ/ stage Ⅰ and
stages Ⅱ/ stage Ⅰ groups. The results of ontology enrichment analysis of total differential protein genes show that KEGG pathway enrichment analysis of differential protein suggested that
there were nine pathways related to silicosis.

Conclusion:

The main biological changes in the early stage of silicosis are glycolysis or gluconeogenesis, autoimmunity, carbon metabolism, phagocytosis, etc., and microfibril-associated glycoprotein 4 may be involved in the early stage of silicosis. The main biological changes in the
late stage of silicosis are autoimmunity, intercellular adhesion, etc. Calcium hippocampus binding
protein may participate in the biological changes in the late stage of silicosis. It provides a new
idea to understand the pathogenesis of silicosis and also raises new questions for follow-up research.
The Effectiveness of Perinatal Omega-3 Supplements in Neurodevelopment and Physical Growth of 9- and 12-month-old Infants: A Follow-up of a Clinical Trial
Authors: Sarrafi Somayyeh , Pourzeinali Samira , Shakouri Seyed Kazem , Farshbaf-Khalili Azizeh , Ostadrahimi Alireza
Published: January 2024

Background:

Omega-3 fatty acids (FAs) are essential long-chain polyunsaturated fatty
acids (LCPUFAs) that are essential for optimal health and development.

Objective:

The present study aimed to evaluate the effectiveness of maternal fish oil (containing
omega-3 LCPUFA) intake from 21th week of pregnancy to 30 days postpartum for neurodevelopment
and growth of infants at 9 and 12 months.

Methods:

This was a follow-up study of a triple-blinded clinical trial. The study population was 9--
month-old infants. Their mothers were randomly divided into two groups of 75 people with a 1:1
ratio to take one fish oil supplement or a placebo daily. The anthropometric indicators of infants at
months 9 and 12 and neurodevelopment at month 12 by the ASQ questionnaire were measured. In
the fish oil and placebo groups, respectively, 73 and 71 infants at nine months, as well as 71 and
69 at 12 months, were analyzed.

Results:

No statistically significant impact was observed following consuming omega-3 capsules
on the neurodevelopmental domains, growth parameters, and the profile of maternal serum FAs (p
> 0.05) except DHA. Neurodevelopmental problems were illustrated in one case in the intervention
group and two cases in the placebo group.

Conclusion:

Perinatal relatively low-dose omega-3 LCPUFAs supplements indicated no statistically
significant impacts on the growth and neurodevelopment of 9- and 12-month-old infants in a
population with low consumption of marine products. Further studies investigating the effect of
higher doses of omega-3 LCPUFAs are suggested.
Diagnostic Value of Short Course Low-dose Prednisolone in Patients with
Clinically Suspected Seronegative Inflammatory Arthritis - A
Retrospective Study
Authors: Shan Sam , Mian Mueed
Published: January 2024

Objective:

We aim to establish the utility of a trial of low-dose systemic glucocorticoid
therapy in the assessment of new clinically suspected inflammatory arthritis patients.

Methods:

We retrospectively identified patients from a private rheumatology practice in Melbourne,
Australia between January 1st, 2019, and December 31st, 2021, who presented with clinically
suspected inflammatory arthritis and subsequently underwent a trial of low-dose prednisolone
(15 mg daily weaned over three weeks in 5 mg increments). We excluded patients with known autoimmune/
inflammatory disorders or concurrent immunosuppression at presentation. We collected
basic participant demographic details and clinical details of their presentation, glucocorticoid response,
investigations, and treatment.

Results:

We recruited 177 participants with a median age of 52, and 69.5% were female gender.
The median symptom time to presentation was 12 months. Hands were the most affected joint in
63.3% and 85% had bilateral disease. Among the participants, 29.4% had synovitis on clinical review
and 75.7% had imaging performed as part of the initial assessment. At presentation, the median
CRP was 11 and the median ESR was 16. 79.7% of the cohort experienced significant improvement
in their arthritis symptoms from low-dose glucocorticoids and 83.6% of the cohort required
long-term immunosuppression for an underlying inflammatory condition. Of those who responded
to glucocorticoids, 92.1% were diagnosed with an inflammatory condition. Rheumatoid
arthritis was the most common overall diagnosis in 28%.

Conclusion:

An initial trial of low-dose glucocorticoids in undifferentiated arthritis patients is useful
in predicting the diagnosis of inflammatory arthritis. It is also a predictor of further long-term
steroid-sparing therapy
Chikungunya Arthritis Treatment with Methotrexate and
Dexamethasone: A Randomized, Double-blind, Placebo-controlled Trial
Authors: Amaral José Kennedy , Lucena Gabriela , Schoen Robert Taylor
Published: January 2024

Background:

Chikungunya fever is a reemerging epidemic disease caused by a single-stranded
RNA alphavirus transmitted throughout by Aedes mosquitoes. Chikungunya virus infection
is a biphasic disease in which 72% to 95% of affected individuals manifest acute chikungunya
fever. Following the acute phase, more than 40% of affected individuals develop arthritis, often
lasting more than 3 months, referred to as chronic chikungunya arthritis, which frequently mimics
rheumatoid arthritis.

Objective:

This study aimed to evaluate the efficacy and safety of treatment of chronic chikungunya
arthritis with methotrexate and dexamethasone in a randomized, double-blind, placebo-controlled
clinical trial.

Methods:

The patients were reassessed for treatment response by the DAS28-ESR, tender joint
count and swollen joint count, Patient Global Assessment, and for secondary measures, including
the Health Assessment Questionnaire Disability Index and Pain Visual Analog Scale.

Results:

Thirty-one subjects were randomized (placebo, n = 16; methotrexate, n = 15); 27 completed
treatment and 4 discontinued during the 8-week blinded period. Among the participants, 96.8%
were female, with mean ± SD age was 52.9 ± 13. The mean ± SD disease duration prior to treatment
was 220.9 ± 51.2 days. At 8 weeks, methotrexate-treated subjects showed a greater numerical
trend towards improvement, but there were no significant differences between methotrexate-
dexamethasone group and dexamethasone (placebo) group

Conclusion:

In this relatively small cohort, all of whom received background dexamethasone,
there was a greater numerical improvement trend in prespecified outcome measures, but
methotrexate in combination with dexamethasone was not superior to dexamethasone in chronic
chikungunya arthritis.
Chest CT Radiomics is Feasible in Evaluating Muscle Change in Diabetes
Patients
Authors: Li Ting , Wu Gang
Published: January 2024

Background::

Non-invasive imaging methods are still lacking for the evaluation of muscle changes in diabetes.

Purpose::

To investigate the feasibility of muscle CT radiomics in evaluating muscle changes in diabetes.

Materials and Methods::

60 diabetics and 60 health controls (HC) were assessed with the method of muscle CT radiomics. 93 CT images of radiomics features of the
pectoralis major muscle (PMM) were obtained by using the software 3D Slicer and were then compared between diabetics and HC cases. The least
absolute shrinkage and selection operator (LASSO) regression method was used to establish a prediction model. The receiver operating
characteristic (ROC) curve was used to determine the performance of the model.

Results::

Diabetics and HC cases differed in 19 radiomics features (P<0.05). By using the LASSO method, 6 features were finally selected. The AUC of the
model in the discrimination of diabetics and HC were 0.92 and 0.90, respectively, for the training cohort and validation cohort.

Conclusion::

Muscle CT radiomics is feasible in evaluating muscle changes in diabetes.
Diagnostic Efficacy of High-frequency Ultrasound (HFU) in Early Diagnosis of
Congenital Hip Dysplasia
Authors: Gu Ran , Yuan Liang , Guan Zhiye , Lin Yudong , Zhang Sicheng , Sun Jun
Published: January 2024

Background::

Hip dysplasia is one of the most prevalent disorders in children and one of the three primary congenital orthopedic deformities. Although there are
numerous existing methods (e.g., CT, MRI and arthrography) for early identification of hip dysplasia, their diagnostic criteria differ widely. It is
critical to establish a safe, accurate, and reliable way for early diagnosis and treatment of hip dysplasia.

Objective::

This study aimed to analyze the diagnostic efficacy of high-frequency ultrasound (HFU) for congenital developmental hip dysplasia and hip
dislocation and to provide a reference for the early diagnosis of congenital hip dysplasia in the future.

Methods::

A total of 104 infants and children suspected of having congenital hip dislocation or developmental hip dysplasia admitted to our hospital from
April 2019 to August 2022 were enrolled as study subjects. All the infants and children were subjected to HFU and X-ray examination in our
hospital. The diagnostic efficacy of HFU for congenital hip dysplasia was observed using X-ray as the gold standard.

Results::

HFU confirmed 79 cases of congenital hip dysplasia, while X-ray confirmed 71 cases. The sensitivity and specificity of HFU were 77.42% and
83.33%, respectively, in the diagnosis of congenital developmental hip dysplasia, 76.47% and 96.55% in the diagnosis of congenital hip
dislocation, and 77.22% and 60% in the diagnosis of congenital hip abnormality, which is very close to the gold standard. According to statistics
on infants and children, the majority of patients were girls, and the left joint was more likely to be affected.

Conclusion::

HFU has excellent diagnostic efficiency for congenital developmental hip dysplasia and hip dislocation, which can be considered an early
assessment method for congenital hip dysplasia in the future.
Identify Diabetes-related Targets based on ForgeNet_GPC
Authors: Yang Bin , Wang Linlin , Bao Wenzheng
Published: January 2024

Background:

Research on potential therapeutic targets and new mechanisms of action
can greatly improve the efficiency of new drug development.

Aims:

Polygenic genetic diseases, such as diabetes, are caused by the interaction of multiple
gene loci and environmental factors.

Objective:

In this study, a disease target identification algorithm based on protein recognition is
proposed.

Materials and Methods:

In this method, the related and unrelated targets are collected from literature
databases for treating diabetes. The transcribed proteins corresponding to each target are
queried in order to construct a protein dataset. Six protein feature extraction algorithms (AAC,
CKSAAGP, DDE, DPC, GAAP, and TPC) are utilized to obtain the feature vectors of each protein,
which are merged into the full feature vectors.

Results:

A novel classifier (forgeNet_GPC) based on forgeNet and Gaussian process classifier
(GPC) is proposed to classify the proteins.

Conclusion:

In forgeNet_GPC, forgeNet is utilized to select the important features, and GPC is
utilized to solve the classification problem. The experimental results reveal that forgeNet_GPC
performs better than 22 classifiers in terms of ROC-AUC, PR-AUC, MCC, Youden Index, and
Kappa.
Pro-oxidant Effects of Repeatedly Heated Sunflower Oil and the Possible
Ameliorative Potential of Elaeodendron transvaalense Leaf Powder in
Sprague Dawley Rats
Authors: Kwape Tebogo Elvis , Masisi Kabo , Kelaotswe Laone , Bati Keagile , Baeti Phazha
Published: January 2024

Background::

Repeated heating of cooking oils induces the overproduction of reactive
oxygen species with an overwhelmed cellular antioxidant defense system, resulting in oxidative
stress, the known cause of cardiovascular diseases. Elaeodendron transvaalense is a medicinal
plant believed to have phytochemicals that help ameliorate the effects of oxidative stress.

Objective::

This study investigated the pro-oxidant effects of repeatedly heated sunflower oil and
the possible ameliorative potential of Elaeodendron transvaalense leaf powder in Sprague Dawley
rats.

Methods::

Four groups of male Sprague Dawley rats were fed for 4-weeks a standard diet supplemented
without (a) control or with (b) 15% (w/w) repeatedly heated sunflower oil (RHSO),
(c) 15% (w/w) non-heated sunflower oil, (d) 15% (w/w) RHSO and 1.5% ETLP.

Results::

Endogenous antioxidants: Catalase and SOD activities were observed to rise significantly
(p <0.05) in Group 2 when compared to Group 1 and Group 3 respectively. A significant
decline in the SOD and catalase activities was observed in group 4 fed RHSO + ETLP. No significant
differences were observed in the body, liver, and kidney weights of Group 2 when compared
with Groups 1, 3 and 4 respectively, and no significant differences were observed when
comparing Group 4 to Groups 1, 2 and 3. The levels of Lipid profiles; Low-density Lipoproteins
(LDL), Total cholesterol (TC), and Triglycerides (TG) were observed to rise significantly (p
<0.05) in Group 2 when compared to Group 1 and 3, while their significant (p <0.05) decline
was observed in Group 4 fed with RHSO + ETLP. The levels of HDL showed no significant difference
across all groups because the p-values for the difference between groups exceeded the
null hypothesis (p <0.05).

Conclusion::

The findings of this experiment indicate the possible ameliorative potential of
ETLP observed in the significantly (p <0.05) reduced SOD and catalase activities. A significant
(p <0.05) decline in the TC, TG, and LDL to desirable levels further indicated the ameliorative
effects.
Design and Simulation of Multi Unmanned Boat Cooperative Obstacle
Avoidance System Based on 5G Edge Computing
Authors: Rao Yinhui , Chen Yuanming , Hong Xiaobin , Lin Xiaodong
Published: January 2024

Background::

Compared to single unmanned boat, multi unmanned boats have more flexible mobility and efficient task completion capabilities, which can effectively expand the types of tasks. However, the traditional independent path planning and obstacle avoidance methods of unmanned boats are difficult to meet the requirements of collaborative operation among multiple unmanned boats due to the lack of information exchange.

Objective::

According to the actual demand of multi unmanned boats' cooperative operation, a
method of multi unmanned boats cooperative obstacle avoidance based on 5G edge computing is
proposed to realize the unified planning and scheduling of multi unmanned boats.

Methods::

Firstly, 5G technology and Kubeedge edge computing tools are used to build a multi
unmanned boat collaborative obstacle avoidance system based on cloud, edge and end collaboration,
and the Kubeedge edge computing platform was optimized by optimizing communication
strategies, building a highly available Kubeedge cluster, building a Harbor image center, and using
Web management interfaces further to improve the reliability and stability of the system. Secondly,
the YOLOR-Deepport multi-target recognition and tracking algorithm based on cloud,
edge and end collaborative network is used to complete the recognition and tracking tasks of obstacle
targets, and a set of EECBS path planning methods based on the Kubedge centralized control
platform is designed to plan collision-free and efficient paths for each unmanned boat in realtime.
Finally, the effectiveness of the system was verified through simulation experiments.

Results::

The experimental results show that compared to the traditional autonomous planning obstacle
avoidance method for unmanned boats, the collaborative planning obstacle avoidance
method proposed in this paper can exhibit excellent performance in dense and narrow scenarios,
with a more reasonable navigation path, a range reduction of 20% - 50%, and higher safety.

Conclusion::

The results show that the cooperative obstacle avoidance system based on 5G edge
computing designed in the paper is feasible, and it can effectively realize the cooperative path
planning and obstacle avoidance of multi unmanned boats.
Exploring the Link between Autistic Traits, Emotional
Intelligence, and Self-efficacy in Understanding Social Anhedonia
Authors: Barahmand Usha , Carvey Kefira , Shamsina Naila , Ancheta Angelica Mae , Sanchez Oscar
Published: January 2024

Autism severity has been found to be associated with social anhedonia.
However, the mechanisms linking the two have not been clarified.

Objective:

The study was designed to examine the link between autistic traits and social
anhedonia. The present study tested a serial mediation model, in which it was hypothesized
that emotional intelligence and self-efficacy were serial mediators of the relationship between
autistic traits and social anhedonia.

Methods:

Data from 245 participants (57.4% females, n = 134) ranging in age from 18 to
65 years were collected through self-report. Participants completed an online composite
questionnaire consisting of The Comprehensive Autistic Trait Inventory, the Wong and
Law Emotional Intelligence Scale, The General Self-Efficacy Scale and the Revised Social
Anhedonia Scale.

Results:

The relationship between autistic traits and social anhedonia was mediated by
emotional intelligence and serially mediated by emotional intelligence and self-efficacy.
Self-efficacy alone failed to link autistic traits to social anhedonia.

Conclusion:

The study provides evidence for the significant role of emotional intelligence
and self-efficacy as mechanisms underlying the relationship between autistic traits and
social anhedonia. The findings are discussed in terms of elucidating the processes through
which autistic traits may confer vulnerability to compromised emotional intelligence and
self-efficacy, which then serve as additional risk factors for social anhedonia.
Analysis of factors affecting organic rice exports in Indonesia
Authors: Harahap Qorimah Handari , Lubis Zulkifli , Supriana Tavi
Published: January 2024

The market opportunities from organic farming which are getting bigger globally are being utilized by farmers in various regions in Indonesia and have succeeded in cultivating organic rice and have quite wide market coverage even abroad. This research aims to determine the factors that influence the volume of organic rice exports in Indonesia. The results of multiple linear regression prove that the domestic price of organic rice, the international price of organic rice and the dollar exchange rate against the rupiah influence the volume of organic rice exports in Indonesia. The price of organic rice, both domestic and international, has a negative effect on organic rice exports. Meanwhile, the dollar exchange rate against the rupiah has a positive effect on organic rice exports. The policy implications based on the research results are (a) Seeing the research results showing that the price of domestic organic rice has a negative and significant effect on organic rice exports, the government must maintain prices (inflation), especially the price of domestic organic rice. (b) When the rupiah depreciates, organic rice exports will increase, but exchange rate stability must be maintained by the government. So the increase in organic rice exports is the result of increased rice production, not just the exchange rate.
A comprehensive and detailed review on Mercury Toxicity
Authors: Manpreetkaur K. Gaur  , Kalpana R. Chavhan
Published: January 2024

Introduction: Mercury is a chemical element with the symbol Hg and atomic number 80. It is also known as quicksilver and was formerly named hydrargyrum. In Ayurveda, use of Mercury in Rasa-Aushadhis has been known to all of us since the era of Nagarjuna who experimented with mercury with intention to eliminate poverty from world. With proper use of mercury in medicinal formulations diseases can be cured but their improper use can lead to various diseases such as Nasabhanga, Mukhroga, Pakshaghat, Twacha Vaivarnya, Unmad and other psychic disorders and can lead to Toxicity. Mercury is an Irritant Inorganic Metal Poison. Metallic mercury is not poisonous when taken by mouth.  Poisoning occurs if the finely divided particles or vaporized mercury is swallowed, inhaled or rubbed on the skin. Material & Methods: Various Samhita Granthas, Articles, Textbooks related to Mercury Toxicity were studied. Results & Conclusion: Wide use of Mercury in Ayurvedic & Siddha medicines is evident since many years. As mercury gets deposited in tissues, it can lead to toxicity as a chronic effect. Also, occupational exposure by means of inhalation of vapors can cause many symptoms such as conjunctivitis, stomatitis, cough, dyspnoea, etc. Case studies also reported how Mercury toxicity can affect CVS, Respiratory & CNS systems. PM Appearances, Medicolegal aspect, Treatment, of Mercury Toxicity and Ayurvedic description were discussed.
Role of Ayurveda medicine in the management of Vishwachi Roga vis-a-vis Cervical Spondylosis
Authors: Shripathi Acharya G.  , Gopikrishna S. Acharya  , Rajeshwari S. Acharya
Published: January 2024

Vishwachi is purely Vataja Nanatmaja Vyadhi explained in classical treatises. It can be correlated to Cervical spondylosis. Clinical features of Cervical spondylosis are pain and stiffness in neck region, pain in upper extremities and wasting of muscles in upper extremities. X - ray findings are decreased joint space between cervical vertebrae, subchondrial sclerosis, osteophytosis and loss of cervical curvature. The disease is usually persisting for longer time. Ayurveda medicines are beneficial in this disease. Avoidance of causation factors (Nidana Parivarjana). Use of Vyadhi Pratyanika Aushadhas, Rasayana treatment, Panchakarma therapy, Pathapathya Prayoga, Yoga and Pranayama and diet therapy are advised in the management of this disease. Frequent weight lifting and heavy exercise should be avoided during treatment. Use of Vatahara, Vedana Sthapaka, Balya, Brimhana, Rasayana, Snehana, Poshaka, Swedana, nutritive, calcium supplementation, Mridu Virechana drugs are done in the management of cervical spondylosis. In this review, the role of Ayurveda medicine in the management Vishwachi Roga vis a vis Cervical spondylosis is discussed.
Understanding Grahani as an Anatomical Structure: A Correlative Study
Authors: Sruthi S  , Mamata Murthy  , Suryakanth V. Ghule
Published: January 2024

The word Grahani incepted from Grahana which means to hold or to retain something. According to Shabdakalpadruma, Grahani is Agnyadhishtana Naadi referring it to a tubular structure. In Samhitas we get references for Grahani as Agni Adhishtana, which is the site for Agni. Grahani also does the Karma of Annagrahana to which Chakrapani comments Grahana means Dharana. Charaka Samhita explains Grahani is situated above Nabhi and it holds Apakwa Anna and eliminates the Pakwa Anna. Susruta and Vagbhata additionally explain Grahani as synonymous to Pittadhara Kala and it extends from Amashaya to Pakwashaya. So, Grahani includes all those anatomical structures wherein Annagrahana, its Shoshana due to Pitta Tejas, Pachana and Vimunchana of Pakwa Anna takes place. The structural and functional involvement of gastro intestinal region in the digestion, absorption, assimilation and excretion of ingested food materials is well understood. This correlative study is an effort to understand the possible anatomical entities and applied anatomy of Grahani as explained by our Acharyas.
An approach towards Pain Management w.s.r. to Udavartini Yonivyapat
Authors: Channabasavva D. Totad  , Nagendra Prasad  , Santoshkumar B. Utlaskar
Published: January 2024

In Ayurveda, diseases related to the female reproductive system i.e., gynaecological disorders are described under the caption of Yoni Vyapada. Women have been placed on an extreme worshiping place due to their power of ‘Janani’- creation. it is needed to give proper care and respect to women. God has blessed the female with the most valuable gift of motherhood.[1] The preparation of motherhood starts with puberty when Rajah-Pravriti i.e., menstruation begins.[2] and by the age of 16 it is fully completed after which she is capable of childbearing.[3] Udavarta Yonivyapada or painful menstruation is a common problem of the females in the reproductive age group & has got a detailed patho-physiology and treatment in the classical literature of Ayurveda.[4] “Arthave Sa Vimukthe Tu Tat Kshanam Labhate Sukham” mentioned by Acharya Charaka substantiate the close similarity of Udavarta with spasmodic dysmenorrhoea. Vegodavarthana leading to Pratiloma Gati of Apana Vata and Rajas is the pathology behind Udavartha Yonivyapath. So, treatment should aim at the relief of pain by normalising the direction of menstrual flow which in turn is by normalising the vitiated Apana Vayu. The present paper is aimed at incorporating all the references regarding Udavartha including Nidana Panchakas from Ayurvedic classics and to show the significance of Basti in normalizing the Apana Vata.
The anatomical concept of Phana Marma: A Review Article
Authors: Kunwar Shivangi  , Verma Deepak
Published: January 2024

Anatomical Elaboration of each and every Marma is necessary to simplify the complexity of knowledge and to utilize it in the practical aspect. In this study we clarify the anatomical structure which can be correlated with Phana Marma. This study is based on the literature related to this Marma. We begin with the compiling the ancient Ayurvedic manuscript and the related modern literature. After simplify the ancient literature and comparing both aspect we concluded that the structure damaged and shows traumatic effect should be the vessels present in the postero-lateral aspect, deep in the nasal cavity i.e. Sphenopalatine Artery. We also elaborated the connection of Eustachian tube pharyngeal opening with this Marma.
Observational review on integrated approach in Post Stroke Management - A Case Series Report
Authors: Veeraj Hegde  , Gururaja H
Published: January 2024

Background: The common cause of hemiplegia is stroke which is of two types: hemorrhagic and infarct. However; there may be other causes like tumor, a space occupying lesion, thrombus or an embolus etc. Aims and Objectives: Integrated therapy approach which is Panchakarama, physiotherapy, acupuncture, occupational therapy in the management for stroke, is planned to facilitate the movement of Vata Dosha, by the obstruction of which the symptoms are manifested. Materials and Methods: 5 cases of Cerebrovascular Accidents presenting with stroke reported in Yenepoya Ayurveda College and Hospital are taken in the study, wherein an explorative observational study design was framed on basis of objective and subjective parameters of motor and sensory functions of the brain to observe the before and after effects of treatment. Discussion: The line of treatment is to bring back the motor and sensory functions of the brain. The treatment protocol included Panchakarma procedures like Snehana (Abhyanga) Swedana, Basti, physiotherapy, accupunture, occupation therapy and diet. Internal medicines boost the blood supply and natural antioxidants increase the oxygenation to the brain, rejuvenates the brain cells, and decrease cell death. There was a marked improvement in motor function soon after starting the Bhahya Abhyanga and Swedana procedures with Basti and the modalities of Physiotherapy and occupational therapy helped in fast recovery to facilitate and improve motor control and hand functions in affected upper limb, to maximize the person's ability to undertake his or her own personal self-care tasks and domestic tasks.
Ayurveda management of Bulky Uterus & Abnormal Uterine Bleeding (AUB) associated with Hypothyroidism: A Case Report
Authors: Pooja Sahu  , Shiromani Mishra
Published: January 2024

Many women are suffering from dysfunctional uterine bleeding (DUB). DUB is defined as a state of abnormal uterine bleeding without any clinically detectable organic, systemic, and iatrogenic causes (pelvic pathology e.g. tumour, inflammation or pregnancy is excluded). The prevalence varies widely but an incidence of 10% amongst new patients attending the outpatient seems logical. As the diagnose is based with exclusion of “organic lesion”, so with the care and facilities to exclude such a lesion, the incidence varies. Currently DUB is defined as a state of abnormal uterine bleeding following anovulation due to dysfunction of hypothalamus-pitutary-ovarian axis (endocrine origine).[1] Abnormal menstrual bleeding pattern have been traditionally expressed by terms like menorrhagia, metrorrhagia, polymenorrhea, and oligomenorrhea. In order to create a universally accepted nomenclature to describe abnormal uterine bleeding, International federation of gynecology and obstetrics (FIGO) and American college of obstetrician and Gynecologists (ACOG) introduce newer system of terminology to describe AUB.
Jalaukavacharana in Bartholin’s Cyst
Authors: Jayanti Dhakad  , Basanti Guru
Published: January 2024

A 33 year old women recently presented with a painful oval to round, well defined cystic lesion over right labia majora. On clinical examination diagnosis of Bartholin’s Cyst was made, which can be correlated with Karnini Yonivyapad in Ayurveda. She had a history of recurrence of Bartholin’s Cyst total 15 times in past 10 years out of which 12 times on her right side and 3 times on her left side and for which she underwent surgical procedure 3 times. In our texts Arogyavardhini Vati is well known for its effect on blood purification, liver, inflammation, digestive problems anemia etc. Kanchnar Guggulu plays a significant role in swelling, cyst and thyroid disorders and Jalauka (leach) counteracts the dominance of Pitta Dosha which is responsible for pain and inflammation and has many enzymes responsible for vasodilation, anticoagulant, anti-microbial property. Patient was treated accordingly with Arogyavardhini Vati, Kanchnar Guggulu orally, Jalaukavacharana (leech therapy) single leech weekly at the site of Bartholin’s cyst under proper observation and care and local wash with Triphala , Neem (Azadirac indica) and Haridra (Curcuma longa) Churna Kwath (decoction) followed by application of Jatyadi oil. After 2-3 sittings of leech therapy (weekly) effect of this Ayurvedic treatment was found to be very impactful.
PENDUGAAN UMUR SIMPAN DAN PERUBAHAN ASAM LEMAK ABON JAMUR TIRAM (Pleurotus ostreatus) SELAMA PENYIMPANAN
Authors: Yuwono Sudarminto Setyo , Immaroh Nundiah Zuhrohfi , Harijono Harijono
Published: January 2024

Jamur tiram dapat dimanfaatkan dalam pengembangan produk abon. Abon, salah satu produk pangan kering, umumnya berbahan baku daging melalui proses perebusan dan penggorengan. Selama penyimpanan, abon jamur tiram mengalami penurunan mutu, seperti munculnya aroma tengik akibat reaksi oksidasi. Penentuan umur simpan atau masa kadaluarsa sangat dibutuhkan agar diketahui batasan waktu produk dalam kondisi layak konsumsi. Tujuan dari penelitian ini adalah untuk mengetahui umur simpan abon jamur tiram serta perubahan asam lemak sebelum dan sesudah penyimpanan. Penentuan umur simpan abon jamur tiram menggunakan metode Accelerated Shelf Life Testing (ASLT) dengan persamaan Arrhenius, penyimpanan pada suhu 35, 45, dan 55°C. Hasil penelitian menunjukkan 60% panelis terlatih menolak abon jamur tiram pada hari ke-147. Mutu kritis warna L* 33,2; a* 18,8; b* 16, nilai peroksida 16,45Meq/kg, asam lemak bebas 0,83 dan TBA 3,46 mg/kg. Penentuan umur simpan menggunakan nilai energi aktivasi terendah, yaitu parameter TBA sebesar 3982,931kal/mol dengan persamaan regresi linier dari plot Arrhenius y = −2.005,5x + 1,5173 dan nilai R2 0,908. Umur simpan abon jamur tiram apabila disimpan pada suhu 25, 27, dan 30°C berturut-turut adalah 515,34; 489,49; dan 458,14 hari. Terdapat enam senyawa baru yang muncul selama penyimpanan, yaitu Octanoic acid, methyl ester (Cas) Methyl octanoate, Pentadecanoic acid, 14-methyl-, methyl ester (Cas) Methyl 14-Methyl-Pentadecanoate, Nonanoic Acid (Cas) Nonoic Acid, 2-Isononenal (Cas) Branched Chain 2-Nonenal, Heptanoic Acid, 3,6,6-Trimethyl-, Methyl Ester (Cas) 3,6,6-Trimethylheptanoic Acid Methyl Ester, 9-Octadecenoic Acid (Z)- (Cas) Oleic Acid, 13-Docosenoic Acid, Methyl Ester (Cas) Methyl 13-Docosenoate. Jenis asam lemak tersebut dapat menimbulkan aroma tengik.
Identifikasi Risiko Kegagalan Proses Produksi Ipam Karangpilang II Menggunakan Metode Failure Mode and Effect Analysis
Authors: Firsta Endah  , Emma Yuliani  , Tri Budi Prayogo
Published: January 2024

PDAM Surya Sembada merupakan BUMD yang bekerja pada bidang distribusi air bersih dengan memanfaatkan Sungai Surabaya menjadi salah satu sumber air bakunya. IPAM Karangpilang II telah mengalami peningkatan kapasitas dua kali, dengan kapasitas terakhir sebesar 2.750 liter/detik. Adakalanya dapat terjadi kendala atau kegagalan pada proses produksinya. Studi ini menggunakan metode Failure Mode and Effect Analysis (FMEA) untuk mengidentifikasi risiko kegagalan pada IPAM Karangpilang II.  FMEA merupakan metode sistematis untuk mengetahui dan mencegah sebanyak mungkin failure mode. Pendekatan risiko yang dilakukan pada metode ini yakni dengan severity, occurrence, dan detection. Nilai-nilai kegagalan tersebut kemudian digunakan untuk mendapatkan nilai Risk Priority Number (RPN). Hasil RPN merupakan perhitungan matematis dari analisa yang telah dilakukan, yaitu hasil dari severity × occurrence × detection. Berdasarkan analisis menggunakan FMEA diperoleh nilai RPN yang tertinggi pada unit clearator yang terjadi pada gradient kecepatan, kecepatan aliran, dan bilangan reynold. Dimana masing-masing potensi memiliki nilai RPN sebesar 80. Perbaikan yang diusulkan yaitu dengan melakukan pengaturan dan pengecekan debit yang masuk secara berkala menggunakan alat flowmeter atau alat pengukur debit pada inlet bak.
Comportamento físico de janelas em fibra de vidro
Authors: Simões N. , Vieira N. , Prata J. , Vieira A.
Published: January 2024

A opção por janelas minimalistas é uma tendência arquitetónica que tem tido um franco crescimento no mercado nacional e internacional e que tem despertado o interesse de vários fabricantes por serem sistemas com um valor comercial apreciável, já que são tipicamente comercializadas para preencher vãos de grandes dimensões. O tipo de abertura é principalmente de correr, o que associado à grande dimensão, resulta num conjunto de desafios a ter em conta no desenvolvimento de janelas. O minimalismo é conseguido com recurso à redução da dimensão dos perfis, em particular nas vistas em alçado. A conjugação da reduzida dimensão dos perfis, a tipologia de abertura de correr e as grandes áreas condiciona o comportamento térmico, acústico, permeabilidade ao ar, estanquidade à água e resistência ao vento.

A opção por perfis não metálicos poderá beneficiar o comportamento térmico e reduzir o impacto ambiental por serem materiais com menor massa volúmica e condutibilidade térmica. No entanto, o seu desenvolvimento tem que ser cuidado de modo a não comprometer a resistência mecânica, já que uma maior deformabilidade dos perfis terá impacto direto nos níveis de permeabilidade ao ar, estanquidade à água e resistência ao vento. A fibra de vidro é um material que pode ser usado para fabricar perfis. O objetivo principal deste trabalho é apresentar a caraterização térmica e física de janelas utilizando esse material.

Baseado nos resultados dos ensaios de permeabilidade ao ar, estanquidade à água e resistência ao vento, assim como nos resultados do cálculo de transmissão térmica, foi possível identificar um conjunto de regras que podem ser usadas para garantir um desempenho satisfatório de janelas de correr minimalistas utilizando fibra de vidro para produzir os perfis. Os ensaios foram realizados no laboratório de Itecons no âmbito do projeto “Evoslide”, cuja empresa promotora líder é a FWD.
Analise Dinâmica do Desempenho Energético de um Envidraçado Termocrómico em Diferentes Zonas Climáticas de Portugal
Authors: Teixeira H. , Glória Gomes M. , Moret Rodrigues A. , Aelenei D.
Published: January 2024

Fachadas de edifícios com grandes áreas envidraçadas tendem a promover trocas térmicas significativas que resultam em necessidades energéticas para climatização elevadas. Os envidraçados termocrómicos podem alterar de forma autónoma e reversível as suas propriedades térmicas e óticas dependendo da sua temperatura, promovendo a mitigação de ganhos térmicos e a melhoria de condições de conforto interior e eficiência energética. Este estudo tem como objetivo analisar o desempenho energético de um envidraçado termocrómico instalado num gabinete orientado a sudeste. Para esse fim, foi utilizado um modelo de simulação dinâmica, anteriormente calibrado com dados experimentais, para avaliar o desempenho energético anual do vidro termocrómico comparativamente ao de um envidraçado convencional incolor com e sem uma película refletora de controlo solar. As necessidades energéticas (aquecimento e arrefecimento) e o consumo energético (aquecimento, arrefecimento e iluminação artificial) foram obtidos para as diferentes soluções de envidraçados nas cidades de Bragança, Lisboa e Faro, representativas de diferentes zonas climáticas de Portugal. Com o envidraçado termocrómico obteve-se uma redução significativa, até 65%, das necessidades energéticas para arrefecimento. Apesar do comportamento dinâmico do envidraçado termocrómico e da diminuição das condições de iluminação natural do gabinete, foi possível obter uma redução do consumo anual energético total até 50%.
Monitorização de estruturas de construção a partir de varões compósitos entrançados (BCRs)
Authors: Sousa J. , Mota C. , Bessa J. , Cunha F. , Fangueiro R.
Published: January 2024

O presente trabalho surge no âmbito de um estudo em que foram desenvolvidos varões de compósito entrançados (BCRs) piezoresistivos através da incorporação de um filamento de fibra de vidro impregnado com nanotubos de carbono (CNTs). Diferentes concentrações mássicas de CNTs [0%, 0,5%, 1%, 1,5%, 2% e 2,5%] foram dispersas em formulações poliméricas de resina epóxi e ácido polilático (PLA). Estas formulações foram, em seguida, utilizadas para impregnar os filamentos de fibra de vidro com pré-tratamento alcalino. O efeito do pré-tratamento alcalino dos filamentos de fibra de vidro dos BCRs foi caracterizado pela técnica de espectroscopia de infravermelho por transformada de Fourier (FTIR). O desempenho piezoresistivo dos BCRs funcionalizados foi avaliado usando um set-up dedicado para medir, simultaneamente, a resposta de deformação mecânica e variação de resistência elétrica, durante cargas de tração cíclicas. Através dos resultados, verificou-se que o sensor piezoresistivo estrutural obtido apresenta uma sensibilidade adequada para substituir varões de aço de alta densidade e suscetíveis à oxidação nas armaduras de betão, por uma estrutura de monitorização inteligente.
Impact of Technology on Human Resource During Covid-19
Authors: Archana Deshpande  , Shipra Jain
Published: January 2024

Technology has become an indispensible aspect of today's environment, and human resource management around the worldhas been impacted in a variety of ways as a result of its adoption and deployment. Technology can have a significant impacton Human Resource Management. The internet and intranet revolutions have altered the way businesses are conductedaround the world. As a result, rapid technical change is beneficial. As a result, rapid technological development aids majorstakeholders in the long run in the growth and efficiency of organizations.Given how technology has altered every part of our life, it is unsurprising that it has had a significant impact on HumanResources. The way we communicate with our employees, keep business data, and evaluate employee performance has allaltered as a result of technology improvements. Technology, when used correctly, may have a positive impact on anycompany's HR operations. It accomplishes this by streamlining, organising, and streamlining the Human Resourcedepartment. However, it should be kept in mind that misusing it can have negative consequences for the company's entirestructure. HR is changing in both positive and negative ways, and keeping up with these changes can be difficult. This articlethrows light on how Human Resources is evolving with technology.
Role of BARD In Women Entrepreneurship Development In Bangladesh
Authors: Kazi Sonia Rahman
Published: January 2024

Women's development is the major concern of the country at present. The government of Bangladesh has been trying to do this job by undertaking various programs and activities. Bangladesh Academy for Rural Development has also been involved in developing the model for women's entrepreneurship development. BARD had started the program of women's development in 1959 and still, it has been going on in implementing this program. The general objective of the study was to analyze and review critically the role of BARD in women's entrepreneurship development in the country. The study indicated that the action research projects of BARD of the 1960s and 1970s were more congenial to develop women entrepreneurs as compared to current ongoing action researches.
Social Media Usage By International Trainees And Its Impact On Entrepreneurship In The Case of EDII
Authors: Ephrem Tefera Gonfa
Published: January 2024

This research investigated about social media usage by international trainees and its impact on entrepreneurship in the case of EDII as of 2011 E.C having 59 total informants joined ITEC program from 30 countries. 26 sample sizes identified with stratified sampling technique and descriptive survey method and chi-square analysis were employed. In the study sample size 61.5% was male and 38.5% were females. According to chi-square the post of new products on social media has an association with an attitude of entrepreneurship. The result revealed that there is an association between gender and attitude on starting own business. 62% of the participants use any Social Media platform for business, whereas 54% used for entrepreneurial purpose. According to the findings Social Media triggered to start their own enterprise (Intention) (62%), and 65% informants will start their own business within the consecutive years till 2022. The study indicated that majority females rejected the social media role to commence business than men (73.35%) and females are not ready to start own business through social media platforms in the coming three years.
Teachers Experiences in Mindfulness and Fitness Program: A Pilot Study
Authors: Hunt Tamerah Nicole , Roberts Kylie , Byrd Megan , Johnson Kaytlyn , Gipson Christina
Published: January 2024

Current research shows that mindfulness and physical training programs have been shown to help reduce stress independently, however, limited research is available exploring the possible additive effects of implementing both training programs together [1, 2]. To test the feasibility and effectiveness of the Mind-Body Fitness program through a case-series pilot program, seven elementary school teachers completed a nine-week mindfulness and fitness program. The Perceived Stress Scale [3] was administered at three time points to measure changes in stress levels, and then a focus group was conducted at the conclusion of the program. Focus groups were analyzed using thematic analysis. Mean scores on the Perceived Stress Scale decreased over time. Three themes were identified 1) Perception of stress levels, 2) Integration of stress reduction, and 3) Program evaluation. A novel approach to the integration of mindfulness and fitness created a program with the benefits and strengths of both. Teachers believed the program helped reduce stress levels. The fitness component highlighted the role of support systems in stress reduction, and the mindfulness component has a carry-over effect in managing stress in and out of the classroom.
The Impact of Psychological Stress on Personal Income, Physical Health and Entrepreneurial Intentions among Entrepreneurs
Authors: Abdelwahed Nadia A. Abdelmegeed
Published: January 2024

Entrepreneurial intention plays a pivotal role within entrepreneurship ecosystems, acting as a catalyst for economic growth and innovation by inspiring individuals to embrace entrepreneurship as a viable career pursuit. The present research delves into the intricate dynamics between stress, entrepreneurial intention, personal income, and physical health within Egypt's entrepreneurial landscape. Grounded in a quantitative analysis of 286 valid samples and utilizing SmartPLS 4, this study unveils compelling insights. It reveals a stark negative correlation between stress and entrepreneurial intention, personal income, and physical health while highlighting the affirmative association between individual income, physical health, and entrepreneurial intention among Egyptian entrepreneurs. These findings underscore the imperative of integrating stress management and mental health support mechanisms into entrepreneurship support programs, offering entrepreneurs invaluable resources to fortify their resolve and adaptability in navigating the entrepreneurial journey.