bluuebunny/crossref_metadata_2025 huggingface dataset:
Secondary Attack Rate among the Contacts of COVID-19 Patients at the Beginning of the Pandemic in Pune City of WesternMaharashtra, India
Authors:   MD (Community Medicine) Associate Professor, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India., Parande Malangori  A
Published: November 2021

Introduction: The COVID-19 was the emerging disease caused by SARS-COV 2. Efficient transmission of this disease occurs through droplets and fomites. As COVID-19 has high transmission and hence susceptible household & non-household close contacts are at high risk of developing disease. Study Objectives: 1) To estimate secondary attack rate of COVID-19 among the contacts during the pandemic in Pune city; 2) To identify factors associated with transmission and development of COVID-19 disease. Material & Methods: This was a retrospective cohort study conducted in the month of June 2020. The sample includes 741 contacts of 119 Laboratory confirmed cases for COVID-19, resides in 15 ward offices areas of Pune Municipal Corporation after written informed consent. A confidential telephonic interview was taken by using a prestructured questionnaire which includes socio demographic data, duration of stay, family background, outcome, type of house, development of symptoms etc. Results: The overall Secondary Attack Rate estimated to be 32.5%, 33.7% among the high risk contacts while 13.3% among the low risk contacts. In this city, 6 wards (40%) out of 15 wards showed SAR of more than 40%. The characteristics of primary cases associated with spread of disease were presence of symptoms and duration between onset of disease and isolation of primary case. The factors significantly affecting SAR were age, comorbidity, no. of family members, type of family, type of house, overcrowding, no. of rooms, bedroom attached with toilet, type of contact & containment zone. Conclusion: Higher SAR was seen in the household contacts. It is necessary to adopt rigorous measures to cut the transmission chain in this area of close contact.
Международно-правовой статус рыбоохранной зоны вокруг Шпицбергена
Authors: Криворотов А. К.
Published: November 2021

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Serenata transnacional por la paz: Juliet Barrett Rublee y Flame of Mexico
Authors: Rashkin Elissa , Arredondo Isabel
Published: November 2021

Este artículo explora el mensaje de paz articulado por la activista feminista Juliet Barrett Rublee en Flame of Mexico( 1932), probablemente el primer largometraje de ficción estadounidense filmado en México y un texto híbrido en muchos sentidos. En particular se analiza la función de la música como discurso comunicacional multivalente.
La señorita Etcétera de Arqueles Vela: mujer, ciudad, modernidad
Authors: Figueroa Obregón Rodrigo
Published: November 2021

Este trabajo analiza La seЦorita EtcОtera de Arqueles Vela como narrativa que se genera a partir de un sistema no-lineal descentralizado. Se llega a la conclusiЧn de que las coordenadas espacio-temporales se disuelven en una narrativa sintОtica, utilizando como ejes la figura femenina, la ciudad y el narrador.
Costumbres funerarias de Xico, Veracruz
Authors: del Palacio Montiel Celia
Published: November 2021

En el presente artículo se hace una descripción de las costumbres funerarias de Xico, una población cercana a Xalapa en el estado de Veracruz, tomando como base los testimonios de informantes clave de la comunidad, los cuales son comparados con otros testimonios de otros lugares cercanos a la región de Xalapa . Se pretende hacer una especie de arqueología de dichas costumbres que se remontan hasta el pasado prehispánico, por lo que los testimonios actuales se confrontan con poemas y estudios de dichas costumbres.
Catalina Creel, la versión contemporánea de la Catrina
Authors: Guerrero Viguri Raquel
Published: November 2021

El presente texto es una reflexión comparativa entre dos figuras emblemáticas de la cultura popular mexicana que en su momento fueron difundidas desde géneros muy particulares de los medios de comunicación con un fin que iba más allá del entretenimiento. La Calavera Catrina de José Guadalupe Posada, y el personaje de Catalina Creel de la telenovela Cuna de lobos, escrita por Carlos Olmos, nacieron desde la crítica con la que sus autores miraban los sucesos cotidianos de sus épocas, es por ello que envueltas en tono fársico ambas figuras han sido emblemas de una sociedad que las siguereconociendo, adorando y recordando desde los altares de muertos hasta los memes de Internet.
Gabriel García Márquez, soñar su sueño
Authors: Guerrero Hazel
Published: November 2021

La muerte de García Márquez vista como un sueño sin fin, recuerda a los distintos momentos en que el sueño aparece en su obra. Ese universo narrativo oscila entre la trágica realidad americana y el sueño, donde la luz es agua y el amor se desarrolla durante el estado de vigilia. Realidad que inspiró ficciones, similar a la que hoy nos horroriza. Una pesadilla de la cual no podemos despertar.
Juan Gelman, amigo de la muerte
Authors: Aguilera Peña Anali
Published: November 2021

A través de un profundo sentir de dolor colectivo presente a fines de 2014, la autora realiza un homenaje al poeta argentino Juan Gelman. Reflexionando sobre la vida y la obra del autor, en el año de su fallecimiento, la autora considera que las experiencias del poeta bajo la dictadura militar en Argentina marcaron su obra de manera que ésta expresara los sentimientos de muchas otras víctimas de la injusticia. No obstante, se apreciará como en otros de sus versos, Juan Gelman logra estar en paz con la muerte, aceptándola como parte del ciclo natural de la vida.
Células Hela, la vida después de la muerte
Authors: Carbajal Rosas Mariana
Published: November 2021

En los 50, la enfermedad terminal de Henrietta Lacks derivó en un caso maravilloso de extensión de la vida. Como parte del tratamiento, su ginecólogo hizo una biopsia de cérvix, que estaba plagado por células cancerígenas. Esta muestra se mantuvo con vida en una caja de Petri después de la muerte de Henrietta. A partir de ellas, el médico George Gey desarrolló una línea celular para la investigación científica, la llamó células HeLa. Hoy día, sobreviven en los laboratorios del mundo, células para la investigación derivadas de esta biopsia. A partir de este caso es que podemos reflexionar sobre el impacto de la ciencia en conceptos básicos como vida y muerte, así como los conflictos bioéticos que surgen.
La muerte en las letras y en otros escenarios...Necrología del 2014
Authors: García Meza Norma Esther
Published: November 2021

La presente necrología se elaboró porque nunca antes la muerte había rondado, tan insistente y dolorosamente, por las letras y otros escenarios, como en este 2014. Nunca antes habíamos tenido a tantos poetas, escritores, pensadores, luchadores sociales, pintores, fotógrafos, periodistas, músicos, cantantes, coreógrafos, bailarines, actores, actrices y, reciente y lamentablemente, estudiantes, a quienes dedicar nuestro altar.
Milk y Arenas, dos contextos políticos de contraste en torno a la diversidad sexual durante los setenta
Authors: Loeza Landa Jorge
Published: November 2021

Se analizan dos casos desde la perspectiva de género: la vida del activista político Harvey Milk y la del novelista Reinaldo Arenas, dos personajes de la vida pública de Estados Unidos y de Cuba, respectivamente, quienes experimentaron la vejación en contra de la comunidad homosexual en sus propios contextos, pero a la vez contemporáneos.
Habanera, la danza que unió fronteras
Authors: Ramírez Uribe Claudio
Published: November 2021

Esta colaboración tiene como objetivo una revaloración de la música de habaneras, dados sus antecedentes históricos y su influencia. Fomenta también la discusión en torno a los elementos amalgamados en el género de habaneras, buscando saber si este fue el detonante creativo de los pueblos hispanoamericanos decimonónicos o se fusionó con elementos musicales ya existentes en éstos.
De Orwell al cibercontrol de Armand Mattelart y André Vitalis
Authors: Rashkin Elissa
Published: November 2021

De Orwell al cibercontrol de Armand Mattelart y André Vitalis.
Subjetividad, cuerpo y mercancía en el capitalismo de ficción
Authors: Juárez Salazar Edgar Miguel
Published: November 2021

El presente texto busca relacionar la noción de intimidad en las dinámicas del capitalismo contemporáneo con las formas ficcionales que sostienen las dinámicas culturales de nuestros tiempos. Desde las reflexiones de Marx sobre la mercancía y su fetichismo, se pretende indagar en las formas actuales de la vida y su exhibición en el capitalismo. La producción cultural de la intimidad es presentada como una directriz que busca olvidar las condiciones políticas de la existencia del sujeto produciendo mecanismos que regulan la actividad de los sujetos a partir del control sobre sus cuerpos, sus conductas y sus relaciones sociales. Estas condiciones precisan un control de los cuerpos y su normalización que permiten estandarizar las formas en las que lo interior es mostrado como público. Ficción y fetichismo construyen el eje por el cual se analizan algunas de las dinámicas de exposición por las cuales el capitalismo construye su eficaz control sobre el cuerpo y la vida subjetiva.
Enseñanza del Derecho en la Pandemia: La clase Magistral interactiva en la virtualidad
Authors: Cázares Sánchez Cristina
Published: November 2021

RESUMEN: La pertinencia de la clase magistral ha sido continuamente cuestionada como estrategia para la Enseñanza del Derecho, en concreto dentro del sistema presencial. Con la emergencia sanitaria a nivel Mundial, este sistema se ha mudado al sistema en línea, predominando las clases sincrónicas como la forma habitual de enseñanza en las Aulas Virtuales. Sin embargo, la estrategia que siguen es la misma de la clase magistral tradicional, por ello, se retoman en este artículo los argumentos, metodología propuestos por varios autores en la Enseñanza Superior, para transformar a la clase magistral en interactiva, donde se rompe el esquema del monólogo, fomentar la participación del alumnado mediante determinadas herramientas tecnológicas. Se propone una estructura de la clase magistral adecuada a la enseñanza en línea emergente, no se trata de una propuesta para la Enseñanza a Distancia, que tiene su propia metodología de enseñanza-aprendizaje.
El futuro empieza hoy
Authors: Contreras López Rebeca Elizabeth
Published: November 2021

RESUMEN: En este texto, Boaventura de Sousa se ocupa del impacto de la pandemia del Covid-19 en el mundo, problematiza sus consecuencias para las regiones y personas más desprotegidas. Desde su punto de vista, la crisis es producida por las condiciones del capitalismo neoliberal que han incapacitado a los Estados para responder a las emergencias, una situación que la pandemia sólo viene a agravar. Sin embargo, en esta situación se pone en evidencia que hay otras formas de vida y alternativas al hipercapitalismo.
КОНЦЕПТУАЛЬНІ ОСНОВИ СТВОРЕННЯ СТРУКТУРНОЇ МОДЕЛІ УПРАВЛІННЯ ФІНАНСОВИМИ РИЗИКАМИ ПРОМИСЛОВОГО ПІДПРИЄМСТВА
Authors: Shyshkina Olena
Published: November 2021

У статті досліджено кризові умови, у яких опинились вітчизняні промислові підприємства. Аргументовано необхідність здійснення ефективного управління фінансовими ризиками в умовах нестаціонарної економіки України. Сформульовано сутність процесу управління та його складових. Наголошено на тому, що спектр необхідних управлінських рішень у сфері ризик-менеджменту значним чином визначається циклічністю розвитку промислових підприємств, тривалістю життєвого циклу галузі / підприємства / технологій та обладнання / продукції, що виготовляється, а також стадіями циклів, на яких перебуває досліджуване підприємство. Доведено доцільність побудови моделі управління фінансовими ризиками, яка може базуватись на одній із трьох форм ризик-менеджменту, що можуть бути представлені зовнішнім, внутрішнім або комбінованим управлінням. Розроблено та представлено узагальнену схему моделі управління фінансовими ризиками промислового підприємства, яка враховує ризикоформуючі фактори зовнішнього і внутрішнього середовища, включає суб’єкт і об’єкт управління, ґрунтується на цілях і задачах управління. Обґрунтовано необхідність врахування наявних нормативно-правових, кадрових, фінансових та інших обмежень, які знатні посилити негативний вплив фінансових ризиків на процеси функціонування і розвитку підприємств та підвищити ймовірність отримання додаткових збитків.
ФІНАНСОВІ ІНСТРУМЕНТИ СТРАТЕГІЧНОГО РОЗВИТКУ СФЕРИ ОХОРОНИ ЗДОРОВ’Я В УМОВАХ ЦИФРОВОЇ ЕКОНОМІКИ
Authors: Zabashtanskyi Maksym , Drahunov Dmytro , Zub Inna
Published: November 2021

У статті розглянуто фінансові інструменти стратегічного розвитку сфери охорони здоров’я в Україні. Розкрито сучасні підходи до трактування дефініцій «цифрова економіка» та «фінансові інструменти», узагальнення яких дозволило розкрити їхній особливий вплив на сферу охорони здоров’я. Проаналізовано пріоритетні напрями розвитку сфери охорони здоров’я в Україні в частині розвитку системи обов’язкового медичного страхування та акцентовано увагу на необхідності його впровадження як одного з ключових фінансових інструментів її стратегічного розвитку. Запропоновано підходи до фінансового забезпечення сфери охорони здоров’я, запровадження яких сприятиме оптимізації наявного обсягу фінансових ресурсів, визначатиме стратегічні пріоритети подальшого розвитку даної сфери в умовах цифрової економіки. Досліджено шляхи вдосконалення фінансового забезпечення сфери
охорони здоров’я в умовах цифрової економіки.
Cloud Service for Multidimensional Processing of Quantitative Data for Solving Geological
Authors: Zagumennov A. A. , Naumova V. V. , Eremenko V. S.
Published: November 2021

The study describes the developed cloud web service for multidimensional processing of quantitative data for solving a wide class of scientific geological tasks. The computing node “Multidimensional methods of data analysis” provides processing of tabular data using various methods of modern data analysis and allows to set their parameters and visualize the results. The node includes wide range of methods such as data preprocessing, descriptive statistics, cluster analysis, factor analysis, correlation analysis, regression analysis. Computing node “Multidimensional methods of data analysis” is a part of Computational analytical geological environment of State Geological Museum of RAS and is integrated with its services. At the same time, the computing node is an independent cloud web service which implements REST API for interaction with it. This allows a wide range of users to access multidimensional data analysis methods located on a computing node and provides capabilities of its integration into information systems as a thirdparty application for processing tabular data.
PENGARUH CAMPURAN TANAH GAMBUT DAN PUPUK KANDANG AYAM TERHADAP PERTUMBUHAN Caliandra callothyrsus
Authors: Ichsani Adizar Razzaq , Burhanuddin Burhanuddin , Latifah Siti
Published: November 2021

Kaliandra (Calliandra callothyrsus) is a plant that includes of  Fabaceae family. Kaliandra has  200 species in a medium-sized tree with compounded flowers. benefits of Kaliandra can produce fast and qualified raw materials energy, especially for pellet production. Producing Energy is for commercial requirements about 4600 kcal per kg of dry wood and 7200 kcal per kg of charcoal. This research purpose is to get the best media in Kaliandra growth. The method of research has been used by Completely Randomized Design (CRD). The research consisted of 6 treatments of planting media (M0, M1, M2, M3, M4, M5).  Those treatments have been 5th replicated therefore become 30 experimental units. These results showed best media is M5 (peat soil: Chicken Manure = 3:1). M5 is the best plant growth media.Keywords: Calliandra growth at peat media AbstrakKaliandra (Caliandra callothyrsus) merupakan tanaman anggota family Fabaceae. Kaliandra memiliki anggota sekitar 200 jenis wujudnya berupa pohon berukuran sedang dengan bunga tersusun majemuk. Manfaat dari Kaliandra dapat menghasilkan bahan baku energi secara cepat dan berkualitas terutama untuk  produksi pelet. Energi dihasilkan untuk syarat komersial sekitar 4600 kkal per kg kayu kering dan 7200 kkal panas per kg arang. Penelitian ini bertujuan untuk mendapatkan media terbaik dalam pertumbuhan Kaliandra. Metode yang digunakan adalah eksperimen dirancang menggunakan Rancangan Acak Lengkap (RAL). Percobaan terdiri dari 6 perlakuan media tanam (M0, M1, M2, M3, M4, M5). Penelitian ini menggunakan 5 kali ulangan sehingga terdapat 30 unit percobaan. Hasil penelitian menunjukan bahwa media terbaik adalah M5(Tanah gambut: Pupuk kandang ayam = 3:1). Media M5 merupakan media dengan pertumbuhan tanaman terbaik.Kata kunci: Pertumbuhan kaliandra pada media gambut
The role of radiation therapy in the treatment of patients with pleural mesothelioma
Authors: Borisova Tatiana N. , Tkachev Sergey I. , Ivanov Stanislav M. , Alieva Sevil B. , Trofimova Oxana P. , Glebovskaya Valeria V. , Breder Valeriy V. , Laktionov Konstantin K. , Marinov Dimitr T. , Abdullaev Amir G.
Published: November 2021

Pleural mesothelioma (PM) remains a disease with a poor prognosis, despite the use of the newest achievements of multimodal treatment. Radiation therapy for PM is traditionally used in some directions: in radical treatment as a part of a three-modal approach, for reducing the risk of chest metastasis in areas of invasive interventions and during palliative treatment. The lack of reliable randomized trials has led to an absence of consensus about the optimal radical treatment strategy. Mordern global recommendations for the treatment of PM are controversial regarding the use of adjuvant radiotherapy in multimodal treatment. Although the role of radiation therapy in the treatment of PM remains unclear, significant successes in planning and conducting radiotherapy are showing that long-term survival can be achieved for these patients, for whom, until recently, only palliative treatment was considered as appropriate treatment. For many years, preventive irradiation of areas of invasive interventions has been used as a method to prevent implantation metastasis. However, a number of randomized trials and recent meta-analysis have not demonstrated the benefits of this treatment approach. Due to the rarity of PM, the severe state of patients and tumor localization, the importance of radiation therapy in the palliative treatment of patients with pleural mesothelioma remains controversial. Recent completed and planned studies allow to commend the role of palliative radiation and recommend it in order to reduce pain.
The relationship of GITR, Lag-3 and PD-1 expression with the main indicators of systemic and local immunity in patients with breast cancer
Authors: Tabakov Dmitrii V. , Zabotina Tatiana N. , Chanturia Naily V. , Zakharova Elena N. , Vorotnikov Igor K. , Selchuk Vladimir Yu. , Sokolovskiy Victor V. , Petrovsky Alexander V.
Published: November 2021

Background. To enhance the antitumor immune response, new promising methods of immunotherapy are being developed. They consist in the blockade and activation of immune check-point molecules, in particular, the blockade of the Lag‐3 molecule (lymphocyte-activation gene 3) and the activation of the GITR receptor (Glucocorticoid induced TNF receptor). In the studies of combined use with PD-1 blockers, encouraging results were obtained, which makes the assessment of the expression of Lag-3 and GITR on immunocompetent cells of peripheral blood (PB) and tumor tissue necessary for the personalization of such treatment and understanding of the mechanisms of the antitumor immune response.
Materials and methods. The study included peripheral blood samples and surgical material from 39 breast cancer patients being treated at the Blokhin National Medical Research Center of Oncology. The subpopulation composition and expression of PD-1, Lag-3, and GITR molecules were evaluated by flow cytometry.
Results. The analysis of the main populations of PB lymphocytes showed that in patients with breast cancer, the content of NKT-lymphocytes was increased, and the proportions of lymphocytes expressing CD11b and CD25 markers were increased compared to the donor group. It was revealed that the tumor tissue is dominated by T-cells, an increase in the proportion of which occurs due to a reduced content of NK-lymphocytes and B-lymphocytes. The structure of Tumor-infiltrating lymphocytes (TILs) is dominated by subpopulations with immunosuppressive activity, which is indicated by a decrease in the content of CD11b+, CD25+ and perforin-positive cells, increased expression of Lag-3 and PD-1. For PB and tumor tissue, the average degree of dependence of Lag-3 expression on the content of PD-1+ lymphocytes was shown. There is an increase in the content of immunosuppressive subpopulations with high PD-1 values in PB and TILs. The direct dependence of the number of perforin-containing lymphocytes and CD11b expression on the GITR content in the PB was established, but it is not typical for breast cancer tissue.
Conclusion. Since the blockade of the Lag-3 molecule by monoclonal antibodies can enhance the effect of anti-PD-1 therapy in cancer patients, it is necessary to evaluate the expression and co-expression of these two markers. A high content of GITR-positive lymphocytes in the tumor tissue, on the one hand, and a decrease in the proportion of effector subpopulations of lymphocytes, on the other, indicates the influence of the tumor microenvironment on the functioning of GITR-mediated activation of the immune response. Further investigation of GITR expression and functional activity is required to understand the nature of this contradiction.
Malignant neoplasm of the bronchi and lung: Russian clinical guidelines
Authors: Laktionov Konstantin K. , Artamonova Elena V. , Borisova Tatiana N. , Breder Valerii V. , Bychkov Iurii M. , Vladimirova Liubov Iu. , Volkov Nikita M. , Ergnian Stepan M. , Zhabina Albina S. , Kononets Pavel V. , Kuz’minov Aleksandr E. , Levchenko Evgenii V. , Malikhova Olga A. , Marinov Dimitr T. , Miller Sergei V. , Moiseenko Fedor V. , Mochal’nikova Valeriia V. , Novikov Sergei N. , Pikin Oleg V. , Reutova Elena V. , Rodionov Evgenii O. , Sakaeva Dina D. , Semenova Anna I. , Smolin Aleksei V. , Sotnikov Vladimir M. , Tuzikov Sergei A. , Turkin Igor N. , Tiurin Igor E. , Chkhikvadze Vladimir D. , Kolbanov Konstantin I. , Chernichenko Andrei V. , Fedenko Aleksandr A. , Filonenko Elena V. , Nevol’skikh Aleksei A. , Ivanov Sergei A. , Khailova Zhanna V. , Gevorkian Tigran G. , Butenko Aleksei V. , Gil’mutdinova Ilmira R. , Gridneva Irina V. , Eremushkin Mikhail A. , Zernova Margarita A. , Kasparov Boris S. , Kovlen Denis V. , Kondrat’eva Kristina O. , Konchugova Tatiana V. , Korotkova Svetlana B. , Krutov Anton A. , Obukhova Olga A. , Ponomarenko Gennadii N. , Semiglazova Tatiana Iu. , Stepanova Aleksandra M. , Tkachenko Galina A. , Khulamkhanova Marina M.
Published: November 2021

Lung cancer has the highest morbidity rate among all malignant tumors in men and the highest mortality rate in men and women in Russia. In total, 49 145 new cases of lung cancer were registered (diagnosed) in Russia in 2019. The majority of cases are related to exogenic carcinogens and mainly tobacco smoke. For several decades surgical resection with preoperative cytotoxic therapy was an optimal approach for maximal cure rate. This year recommendations were updated with new strategies including adjuvant anti-PD-L1 atezolizumab following completion of chemotherapy in PD-L1 positive patients and osimertinib for EGFR mutated cases. For this moment available data suggest the increase in disease free survival. Strategic approach to treatment for inoperable patients varies according to the status of driver mutations. New approach includes pretreatment option of testing for a wide spectrum of alterations with NGS based panels. Significant changes were incorporated into treatment of ALK mutated NSCLC with two new options of brigatinib for TKI naive patients and lorlatinib for those who progress on second generation drugs. Treatment strategy for patients without activating mutations is based on PD-L1 status. Tsis year recommendations included atezolizumab as a new monotherapy option for patients with high depression of PD-L1. Also treatment options for pembrolizumab, nivolumab and atezolizimab were widened with prolonged treatment schedules.
Influence of correction of nutritive deficiency on the effectiveness of neoadjuvant chemotherapy in patients with locally advanced gastric cancer
Authors: Brish Nadezhda A. , Semiglazova Tatiana Yu. , Karachun Aleksei M. , Shevkunov Lev N. , Ulyanchenko Yana A. , Artemyeva Anna S. , Golovanova Tatiana S. , Tkachenko Elena V. , Alexeeva Yuliia V. , Sharashenidze Sofiko M. , Strakh Liubov V. , Protsenko Svetlana A. , Teletaeva Gulfiia M. , Filatova Larisa V. , Kasparov Boris S. , Semiglazov Vladislav V. , Belyaev Aleksei M.
Published: November 2021

Aim. To increase the effectiveness of neoadjuvant chemotherapy in patients with locally advanced gastric cancer by correcting nutritional deficiency.
Materials and methods. Of 200 patients with locally advanced gastric cancer (mean age 57.2 years (46.168.3), 100 patients received neoadjuvant chemotherapy with nutritional support from 2018 to 2020. One hundred patients received neoadjuvant chemotherapy without nutritional support from 2013 to 2018 (historical control). The incidence of nutritional deficiency before treatment in the neoadjuvant chemotherapy + nutritional support group was 54%, and in the neoadjuvant chemotherapy only group it was 47%. Nutritional status was assessed using anthropometry, questionnaires (NRS-2002, MUST, GLIM), dynamometry, blood tests, bioimpedance. Complications according to NCI CTCAE v5.0; оbjective response rate according to RECIST 1.1; pathomorphological regression according to the JGCA classification (2017); 2-year event-free survival were assessed.
Results. The frequency of nutritional deficiency before the start of treatment in the neoadjuvant chemotherapy + nutritional support group was 54%, in the neoadjuvant chemotherapy only group 47%. After the completion of neoadjuvant chemotherapy in the group neoadjuvant chemotherapy + nutritional support the frequency of nutritional deficiency was 1%, in the group neoadjuvant chemotherapy only without nutritional support 62%. In patients with nutritional deficiency in the neoadjuvant chemotherapy + nutritional support group, partial regression was registered in 51.9% of cases, in the neoadjuvant chemotherapy only group it was 27.6% (p0.05). There were no differences in the frequency of pathological response. 2-year event-free survival in patients without nutritional deficiency in the group neoadjuvant chemotherapy + nutritional support was 100%, in the neoadjuvant chemotherapy only group it was 68.5% (p0.001); in patients with nutritional deficiency 72,5 and 60.6% respectively (p0.05).
Conclusion. Nutritional deficiency is an important predictive and prognostic marker of the efficacy of neoadjuvant chemotherapy in the treatment of locally advanced gastric cancer. Comprehensive diagnosis of nutritional status and nutritional support can improve the results of neoadjuvant chemotherapy in patients with locally advanced gastric cancer.
Dual immunological blockade in the treatment of metastatic non-small cell lung cancer: reality and perspectives
Authors: Yudin Denis I. , Laktionov Konstantin K. , Laktionova Liudmila V. , Breder Valeriy V.
Published: November 2021

Nowadays immunotherapy is a crucial option in the treatment of non-small cell lung cancer. There are a lot of actual options of the first-line therapy for the patients with metastatic lung cancer, including dual immunological blockade of PD-1/PD-L1 and CTLA-4 pathways. This review is an attempt to clarify the place of dual immunological blockade now and in the future. The scientific rationale for dual immunotherapy is a possible synergy and overcome resistance to single-drug therapy. The review collected information from open sources, both current studies with dual immunological blockade, and already obtained results of the trials for nivolumab and ipilimumab, tremelimumab and durvalumab, and other combinations for the treatment of patients with metastatic non-small cell lung cancer. This approach is promising for the possible overcoming of resistance to monoimmunotherapy with anti-PD1/PD-L1 antibodies, especially in the population with low and negative PD-L1 status.
Network meta-analysis for clinicians
Authors: Bogdanov Alexey A. , Bogdanov Andrey A.
Published: November 2021

Decision making in clinical practice requires consideration of the relative efficacy and safety of medical interventions. A systematic review and meta-analysis, the results of which have the highest level of confidence in evidence-based medicine, only compare the effectiveness of two interventions, provided that there is a direct comparison between them in a set of randomized controlled trials. The development of statistical methods has led to the development of the network meta-analysis method, the application of which allows comparison for more than two interventions and even if the interventions were not directly compared in randomized controlled trials, but have a common comparison intervention. As a result, network meta-analysis is increasingly being used as an evidence base for the effectiveness of medical interventions. However, there are important assumptions and conditions underlying the performance of network meta-analysis. In this work, we tried to outline the main aspects of network meta-analysis that are important for clinicians in terms of its implementation and interpretation of its results.
IMPLEMENTACIÓN DEL CORREDOR DE ESTADIA PARA PROMOVER EL TURISMO CULTURAL EN EL DISTRITO DE ZAÑA
Authors: Castro Colchado Erlinda Ariadna Isabo , Samillan Rodríguez Daniel
Published: November 2021

El objetivo de este trabajo es analizar cómo la buena implementación del Corredor de Estadía solucionará la falta de equipamiento profesional, promoverá e integrará las diferentes necesidades culturales del Distrito de Zaña. Por ser un atractivo turístico, tiene un patrimonio suficiente para atraer a un gran número de turistas nacionales y extranjeros. Buscar mejorar las condiciones de la infraestructura turística y otras labores de promoción turística. El método aplicado es descriptivo y explicativo, y no es un tipo de diseño experimental de correlación transversal / causal. En 2018, la muestra se dirigió a 357 habitantes del Distrito de Zaña. La principal herramienta utilizada es la encuesta, que se realiza en el software SPSS (22). Como resultado final, el total de vecinos de Zaña; el 85% piensa que debería tener una mejor planificación; el 70% debe tener equipo especial; el 97% piensa que los monumentos históricos se pueden exhibir mejor. Inferir la riqueza de Zaña requiere un fuerte impulso para viajar. Ante este problema, se recomienda que el gobierno municipal de Zaña diseñe una infraestructura para reactivar y promover el turismo restaurando sus ruinas y difundiendo sus costumbres; de acuerdo con las necesidades de la población y los planes nacionales.
Управління проєктами як інструмент розвитку для суб’єктів бізнесу
Authors: Євчук Людмила Анатоліївна
Published: November 2021

Управління поточною діяльністю бізнесу та його розвитком має здійснюватися по-різному. Розкрито і доведено необхідність відокремлення завдання розвитку бізнесу у самостійний проєкт і застосування до нього проєктної методології управління, вказано її переваги. Досліджено статистику зміни кількості зареєстрованих суб’єктів діяльності за останні роки. Зазначено яким чином проєктний підхід дозволяє вирішити проблему росту бізнесу для компаній, що швидко розвиваються. Наголошено на неправильних акцентах уваги підприємців під час розвитку бізнесу. Обґрунтовано необхідність розрахунку бізнес-плану розвитку бізнесу та дослідження його цільової аудиторії. Наведено прогресивні стилі управління підприємством та проєктами. Вказано основні види методології управління проєктами та доцільність застосування спеціалізованих програмних продуктів.
Contracting for social and welfare services : the changing relationship between government and the voluntary sector in New Zealand
Authors:   , Smith Verna May
Published: November 2021

Ten years ago, the provision of government funding for the social and welfare services delivered by voluntary sector service providers was a simple process. In evidence presented to the Waitangi Tribunal in support of a claim by a Charitable Trust against the actions of the New Zealand Community Funding Agency heard last year, a witness who was employed by the Department of Social Welfare from early in 1988 describes the process at that time thus: The Department of Social Welfare has operated funding programmes for many years...these programmes were grant funding. That is there was no contracting nor reporting as presently known. Also they were operated on a Head Ofiice Wellington decision on the recommendation of a small team (3 or 4 people based in a Regional OfiBce Auckland).(Crown Law Office, 1994 c, 6) This simple process has, in the last decade, been replaced by a funding relationship between government and the voluntary sector which owes its origins primarily to theory emanating from the study ofthe operation of private markets and the internal organisation of firms within the marketplace. Agency theory and Transaction costs analysis, along with other theoretical perspectives from the world ofthe private business sector, have had a substantial influence upon the restructuring ofthe public sector in New Zealand during the last decade and in particular have provided the theoretical basis for the transformation of the relationship between government and the voluntary sector into one of principal and agents, bound by contractual terms and a regulatory framework for the monitoring of quantity and quality of social and welfare service outputs.
Non-Pharmacological Management of Pruritus in Chronic Kidney Disease Patients at Panti Waluya Sawahan Hospital
Authors: Perwiraningtyas Pertiwi , Sutriningsih Ani , Metrikayanto Wahyu Dini
Published: November 2021

Patients of chronic kidney disease require long-term hemodialysis therapy. However, this therapy has various complications, one of which is pruritus. Pruritus can interfere with individual activities, cause sleep disturbances, lesions and hyperpigmentation on the skin, to impact the patient's quality of life. So that non-pharmacological management is needed to treat pruritus. The design was cross sectional. The population in this community service was chronic kidney failure patients undergoing hemodialysis therapy in the hemodialysis room. The sample was patients who experience pruritus and undergo hemodialysis therapy at least 1x / week as many as 45 people. The variables were health education related to non-pharmacological management and pruritus. The instruments used leaflets and counseling program units for health education, while for pruritus used the Numeric Rating Scale. The average patient experienced pruritus on a scale of 5, which was a moderate category where itching was felt by frequent scratching. After health education, patients understand how to deal with pruritus with non-pharmacological methods so that the patient's quality of life becomes better
IPO, private capital? Not! SPAC!
Authors: Kovalev A.
Published: November 2021

The introductory part of the article is devoted to a brief overview of the typical methods of raising funds for a company’s capital. Then, I compared The pros and cons of each approach. Further, the author introduces the company’s new fundraising – through the merger with a SPAC (from now on referred to as the merger with SPAC). The article discusses the advantages and disadvantages of this option for a company to enter public capital markets or raise capital in a company compared to the already traditional methods – raising private capital and entering public capital markets through an IPO. As a result of this comparison, the author concludes that the merger with SPAC has the advantages of both classical options for raising capital, without their disadvantages, which makes this option a unique offer on the market. Statistical data confirmed this conclusion. The separate section in the article is devoted to the peculiarities and complexities of the merge with SPAC. The advantages of the merger with SPAC for the leading Russian companies compared with other types of capital raising are separately highlighted, and the contrast between the placement on the MICEX and the merger with SPAC. The article also presents statistics on the public capital market and the impact on the public market of the new opportunity for companies to go public. In the final section of the article, the author discloses the chain of events that brought the merger with a SPAC such a fame and popularity at the current moment in time. The article resulted in an explanation of the attractiveness of institutional investors’ investment of funds in companies that have chosen the merger with a SPAC as a potentiality for entering public capital markets.
Camera Obscura or the Way Things Appear: Some Remarks About Marx’s Economic Writings
Authors: Mierzwa Z.
Published: November 2021

I analyse the foundations of Marx’s analysis to examine the applicability of Marx’s theory of the capitalist economy to the study of current economic events. In this paper, I do not present critique the interpretations of Marx’s works made by contemporary economists; however, much of modern Marxian economics is invalid in terms of Marx’s own method and inappropriate for understanding modern capitalism. The paper is concerned with topics that have been the subject of contemporary debate and are central to Marx’s own economic writings. Here I present only textual evidence of the main tendencies in the development of capitalism discovered by Marx. There are limits to value (= time) as the sole criterion of economic expediency; the constant reproduction of a scarcity of jobs amid an abundance of goods; enlargement of material commercial relations on the other spheres of social life; development of monetary relations – the emergence of derivatives of money, i. e., ersatz money, digital money. The main conclusion that I came to is that some societies are gradually losing value and moral guidelines, threatening the very development and even the existence of other communities or peoples.
COMPARATIVE CHARACTERISTICS OF THE DEVELOPMENT OF SPEED AND POWER CAPACITIES IN THE PRE-COMPETITIVE MESOCYCLE IN TAEKWONDO
Authors: Koshcheev Alexander , Dolbysheva Nina
Published: November 2021

The article presents the features of special physical training of athletes in the stage of sports improvement in taekwondo. It is shown that this stage forms and implements a comprehensive base of all aspects of training of athletes, which will allow performing effectively in competitions. The specificity of taekwondo, which is an Olympic sport, is rapidly increasing the requirements for special physical training of athletes. Taking into account this provision in the training of young athletes is a relevant scientific study and can increase the efficiency of the training process, as well as solve the main tasks of the stage of sports improvement
Pendampingan Kerja Praktik Untuk Meningkatkan Ketrampilan Proses IPA Bagi Guru Guru SD Di Kota Mataram
Authors: I Wayan Gunada  , Sutrio  , Wahyudi  , Ni Nyoman Sri Putu Verawati  , Ahmad Busyairi  , Ananda Fatara Suwandi
Published: November 2021

In elementary schools (SD), KIT IPA equipment is used to practice teaching and learning activities that teachers have not used to their full potential. Kit of knowledge and management abilities Teachers require IPA SD to advance their school. The management of KIT IPA is less effective and has become a major issue for elementary schools (SD) Group IV Cakranegara. The goal of this community service activity is to teach people about the names of the tools in some SD IPA KIT IPA SD, how to use them, and how to use KIT IPA SD in the learning process. This devotional activity employs lecture methods, simulations, and practical work. This activity was held in SD Negeri 1 Cakranegara, with as many as 28 teachers participating. The activities' outcomes demonstrated that participants gained knowledge and skills on how to teach IPA by utilizing KIT IPA tools for practical work activities. Based on observations from practical work, the average value of process skills of teachers was 70 and classified quite well. The positive response from teachers in mentoring activities indicates that this activity is running smoothly, and it is expected that there will be additional training for other KIT equipment as a result of this activity.
Multiple Role of Women Workers In Institution of Social Security Employment
Authors: Hidayati Roziana Ainul , Aisyah Siti
Published: November 2021

Nowadays the existence of women in the world of work is increasing. The phenomenon of women to have a dual role can not be damned. The tendency of women to work raises problems. When working women are faced with the demands of work, while when they are at home women will be faced with domestic roles. In this case working mothers can have different performance. The purpose of this study is to analyze how the quality of the performance of women workers who have a dual role in the BPJS Employment Gresik office. The method used in this study is qualitative. Informants in this study are mothers who have multiple roles who have 9 children. Based on the results of research and discussion on the quality of performance of women workers who have multiple roles, the researchers came to the conclusion that women workers who have multiple roles still carry out their work well so as to achieve optimal performance
Contents
Authors: Ortiz-Molina María Angustias , Sadio-Ramos Fernando José
Published: November 2021

It collects all the contents of the number in an orderly manner and with indication of the pages in which they appear.
Pengaruh Locus Of Control Internal Dan Interaksi Sosial Terhadap Hasil Belajar Matematika
Authors: Islamiati Dian , Haeruddin Haeruddin , Sugeng Sugeng
Published: November 2021

Penelitian ex post facto ini bertujuan untuk mengetahui pengaruh locus of control internal dan interaksi sosial terhadap hasil belajar matematika siswa kelas VII SMP Negeri 9 Samarinda. Populasi dalam penelitian ini ialah seluruh siswa kelas VII yang berjumlah 256 siswa di SMP Negeri 9 Samarinda. Pengambilan sampel menggunakan teknik cluster random sampling, sehingga diperoleh sampel 157 siswa. Instrumen penelitian menggunakan angket dan tes hasil belajar matematika, dan sebelum digunakan untuk pengambilan data, dilakukan uji coba pada siswa kelas VII di SMP Negeri 9 Samarinda sebanyak 59 siswa. Data penelitian dianalisis menggunakan teknik statistik deskriptif dan inferensial. Hasil analisis menunjukkan bahwa locus of control internal dan interaksi sosial siswa tergolong tinggi, sedangkan untuk hasil belajar siswa tergolong pada kategori sedang. Hasil analisis inferensial, diperoleh persamaan regresi dugaan, yaitu Y=34,702+0310X1+0,234X2 dengan nilai probabilitas ρ=0,000. Untuk α=5%, ternyata ρ<α sehingga persamaan regresi yang diperoleh berarti dengan R2 sebesar 0,235. Untuk variabel locus of control internal(X1) diperoleh nilai probabilitas ρ=0,003 dan untuk variabel interaksi sosial (X2) diperoleh nilai probabilitas ρ=0,017, sehingga terdapat pengaruh interaksi sosial terhadap hasil belajar matematika. Dengan demikian, dapat disimpulkan bahwa terdapat pengaruh locus of control internal dan interaksi sosial terhadap hasil belajar matematika siswa kelas VII SMP Negeri 9 Samarinda.
PEMBINAAN KADER PADA PROGRAM PERENCANAAN DAN PENCEGAHAN KOMPLIKASI (P4K) PADA IBU HAMIL
Authors: Erlinawati Erlinawati , Kusumawati Nila
Published: November 2021

Angka kematian Ibu (AKI) dapat menggambarkan tingkat kesadaran perilaku hidup sehat, status gizi dan kesehatan ibu, kondisi kesehatan lingkungan, tingkat pelayanan kesehatan terutama untuk ibu hamil, pelayanan kesehatan waktu ibu melahirkan dan masa nifas. Untuk mempercepat penurunan AKI di Indonesia, pemerintah telah mengeluarkan berbagai macam kebijakan, seperti program perencanaan persalinan dan pencegahan komplikasi dengan stiker (P4K). Program yang dikeluarkan oleh Menteri Kesehatan pada tahun 2007 ini merupakan upaya terobosan dalam percepatan penurunan angka kematian ibu dan bayi baru lahir melalui kegiatan peningkatan akses dan kualitas pelayanan yang sekaligus merupakan kegiatan yang membangun potensi masyarakat khususnya kepedulian masyarakat untuk persiapan dan tindak lanjut dalam menyelamatkan ibu dan bayi baru lahir. Desa Ridan Permai merupakan salah satu desa di Kabupaten Kampar dengan masalah AKI. Menurut penelitian, kader mempunyai peranan yang cukup penting dalam pendampingan ibu hamil dengan harapan dapat menurunkan angka kematian ibu. Namun kenyataan di lapangan masih banyak kader yang belum memiliki pengetahuan yang memadai mengenai masalah kesehatan khususnya tentang kehamilan. Berdasarkan permasalahan tersebut, penyelesaian masalah yang telah dilakukan adalah memberikan penyuluhan tentang P4K. Metode pelaksanaan pengabdian masyarakat dilaksanakan secara kuantitatif dan kualitatif dengan metode FGD dan interview, lokasi di Posyandu Desa Ridan Permai pada tanggal 2, 12 dan 17 September 2019 dengan sasaran kader posyandu ibu hamil. Kegiatan penyuluhan telah meningkatkan pengetahuan kader di desa Ridan Permai tentang P4K.
PEMERIKSAAN TUMBUH KEMBANG BALITA DI TPA TAMBUSAI KABUPATEN KAMPAR
Authors: Syahda Syukrianti , Kasumayanti Erma , Mayasari Endang
Published: November 2021

Untuk mendapatkan sumber daya manusia yang berkualitas perlu dilakukan pemantapan terhadap tumbuh kembang anak agar tidak terjadi kelainan. Pemantauan tumbuh kembang Balita bertujuan untuk mengobservasi dengan melihat perkembangan normal balita. Kegiatan pengabdian ini dilakukan dengan metode pemeriksaan tumbuh kembang, ceramah dan demonstrasi. Hasil pemeriksaan Balita di TPA Tambusai terkait Tumbuh Kembang diketahui bahwa dari 12 Balita yang diperiksa terdapat 2 Balita (17%). yang mengalami keterlambatan atau gangguan perkembangan. Sedangkan 10 Balita (83%)berada pada kategori normal. Terdapat peningkatan sebanyak 75% pengetahuan dari peserta tentang pemantauan tumbuh kembang Balita di TPA Tambusai. Hasil pelatihan tumbuh kembang balita di TPA Tambusai yaitu 100% mampu mempraktikkan cara mendeteksi tumbuh kembang. Berdasarkan hasil kegiatan PKM diharapkan kepada pengasuh untuk melakukan stimulasi kepada anak yang tidak normal dan kepada kepala TPA untuk melakukan skrining disetiap tahapan perkembangan anak.
PKM PEMASANGAN ALAT FILTRASI AIR UNTUK PENINGKATAN KESEHATAN GINJAL MASYARAKAT DESA TUBAN
Authors: Samsudin Rinza Rahmawati , Ponidi Ponidi , Triastuti Nenny
Published: November 2021

Masyarakat Dahor memenuhi kebutuhan air minum dari air tanah dengan cara membuat sumur gali disekitar perbukitan kapur. Pada umumnya air yang mengalir pada daerah batuan kapur memiliki tingkat kesadahan yang tinggi. Program kegiatan yang dilaksanakan diantaranya pertemuan kesepahaman antara mitra dan tim pengusul untuk memadukan persepsi atas program, pertemuan dengan kepala desa dan perangkat desa untuk menyampaikan persiapan pelaksanaan pengabdian, penyuluhan tentang pentingnya konsumsi air layak minum, penyuluhan kesehatan tentang pentingnya mengetahui gejala, pencegahan dan pengobatan terhadap penyakit akibat mengkonsumsi air yang tidak layak minum, proses pemasangan alat filtrasi air dan penyuluhan cara maintenance/perawatan rangkaian alat pengolah air sumur layak minum. Pemasangan alat filtrasi air yang berlokasi di penampung induk Desa Dahor dilakukan oleh dosen teknik lingkungan dan disaksikan langsung oleh perangkat Desa Dahor, bahkan tidak sedikit dari warga desa yang ikut membantu memasang alat filtrasi air tesebut. Terpasangnya alat filtrasi air diharapkan dapat meningkatkan kualitas air layak minum dan kualitas kesehatan masyarakat di desa Dahor Tuban.