bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced low‐field energy storage performance in Nd3+‐doped (Bi0.40K0.2Na0.2Sr0.2)TiO3 high‐entropy ceramics
Authors: Lin Jiawei , Liu Tianyu , Meng Dongdong , He Qiang , Ye Wenhui , Ma Jinxu , Chen Kepi
Published: October 2024

The burgeoning requirement for compact electronic devices has intensified research into lead‐free dielectric ceramics that offer superior recoverable energy storage density and efficiency at low electric fields. In this study, we report the synthesis of Nd3+‐doped (Bi0.4K0.2Na0.2Sr0.2)TiO3 perovskite ceramics via the solid‐state reaction technique. The synthesized ceramics adopted a tetragonal crystal structure. As the concentration of Nd3+ ions increased, both the maximum dielectric constant (εm) and its corresponding temperature (Tm) decrease. The incorporation of Nd3+ ions perturbed the long‐range ferroelectric order, leading to diminished maximum polarization (Pm) and remanent polarization (Pr). The ceramics achieved optimal properties with 12 mol% Nd3+ doping, showcasing a significant recoverable energy storage density of 1.50 J/cm3 at a low electric field of 140 kV/cm, along with an exceptional storage efficiency of 94.6%. This research not only highlights a promising candidate for dielectric materials in low electric field applications but also introduces an innovative approach to enhance energy storage performance.
Surface decoration of Nb2O5 hollow fibers by graphene oxide for enhanced photocatalytic degradation of methylene blue
Authors: Ferreira Eduardo de Paulo , Ribeiro Stella Rodrigues Ferreira Lima , Sousa Thiago Sousa e , Cardoso Vicelma Luiz , Reis Miria Hespanhol Miranda
Published: October 2024

This paper describes the fabrication of ceramic Nb2O5 hollow fibers covered by a thin graphene oxide (GO) layer using the vacuum‐assisted dip‐coating process for the efficient photocatalysis degradation of methylene blue (MB) under UVC light irradiation. Pristine and GO‐coated Nb2O5 hollow fibers were evaluated for photocatalytic degradation at different initial dye concentrations and pH values. A photodegradation of 66.4% of the dye molecules was achieved using the pristine Nb2O5 hollow fibers at 57.4 ± 0.1 mg mL1, initial MB concentration of 10 mg L−1, and pH of 11. Under the same experimental conditions, the GO‐coated Nb2O5 hollow fibers degraded 100% of the MB molecules. Additionally, the GO‐coated Nb2O5 hollow fibers were successfully reused for four reaction cycles and exhibited suitable long‐term stability. Thus, the proposed ceramic Nb2O5 hollow fibers with a surface decorated by a GO layer presented suitable characteristics for use as a photocatalyst in MB degradation.
The effect of digital storytelling on nursing students' compliance with isolation precautions and their knowledge levels: A randomized controlled trial
Authors: Bıyık Bayram Sule , Gülnar Emel , Caliskan Nurcan , Torun Kılıç Çiğdem
Published: October 2024

Background

Digital storytelling is a teaching tool that can help nursing students master the curriculum and improve their skills. This study investigated the effect of digital storytelling on nursing students' knowledge levels and compliance with isolation precautions.

Methodology

A pretest‐posttest open‐label randomized controlled trial. This study was conducted in the nursing department of the faculty of health sciences of a university in Türkiye. The sample consisted of 109 fourth‐year nursing students divided into experimental (n = 66) and control (n = 43) groups. Data were collected using a Demographic Characteristics Questionnaire (DCQ), the Isolation Knowledge Test (IKT), the Questionnaire of Students' Opinions on Digital Storytelling (QSODS) and the Scale of Compliance with Isolation Precautions (SCIP). The experimental group participated a digital storytelling activity, whilst the control group received an education based on the curriculum. The data were analysed using the Mann–Whitney U test, the Wilcoxon test, analysis of variance (ANOVA), and the Spearman correlation test.

Results and Conclusions

The experimental group had significantly higher posttest IKT and SCIP scores than the control group (p < 0.05). Both groups had lower IKT and SCIP scores 2 months after the experiment. However, the change was much smaller in the experimental group. Digital storytelling helped the experimental group participants learn about isolation precautions and how to comply with them. Digital storytelling also promotes learning retention. In conclusion, digital tools are effective in distance learning.
Pre‐service teachers' collaborative learning and role‐based drama activity in a virtual reality environment
Authors: Näykki Piia , Pyykkönen Saara , Latva‐aho Jenni , Nousiainen Tuula , Ahlström Emilia , Toivanen Tapio
Published: October 2024

Background

In recent years, the use of virtual reality (VR) environments for education has gained interest in research and education. However, little is known about the potential of social VR environments for collaborative learning.

Objectives

This study explores pre‐service teachers' (PSTs') collaborative learning and role‐based drama activity, focusing on their self‐created fictional avatar characters and their experiences of presence while working on a group‐based virtual drama activity.

Methods

PSTs' course on environmental storytelling was used as the context of the study, in which they worked in small groups in a VR environment (AltspaceVR) from the desktop computers due to COVID‐19 restrictions. Qualitative research data were collected via questionnaire (N = 15). The data were analysed using a community of inquiry model to explore the PSTs' experiences of online presence.

Results and conclusion

The results showed that the PSTs' experienced creating and acting as virtual characters as meaningful and engaging activities, and elements of presence were manifested in their reflections. Based on this case study, it can be concluded that the interactive virtual drama activity has the potential to foster the experience of presence in online learning.
Efficacy and safety of vancomycin compared with those of alternative treatments for methicillin‐resistant Staphylococcus aureus infections: An umbrella review
Authors: Purja Sujata , Kim Minji , Elghanam Yomna , Shim Hae Jung , Kim Eunyoung
Published: October 2024

Objective

To summarize the evidence on the efficacy and safety of vancomycin compared with those of alternative treatments in adult patients with methicillin‐resistant Staphylococcus aureus (MRSA) infection.

Methods

PubMed, Embase, and Web of Science were searched up to December 15, 2023, for systematic reviews and meta‐analyses comparing vancomycin with alternative MRSA treatments. Primary outcomes included clinical cure and microbiological eradication rates. Organ‐specific safety outcomes were assessed. Summary estimates were recalculated using a random‐effects model. Evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool. This study was registered in PROSPERO (CRD42022340359).

Results

This umbrella review included 19 studies and 71 meta‐analyses (46 efficacy and 25 safety) comparing vancomycin with 10 alternative treatments across different MRSA infection types and populations. GRADE assessment showed that 29.58% of the meta‐analyses were of high quality. Linezolid and daptomycin showed higher efficacy in MRSA‐induced skin and soft tissue infections and pneumonia (moderate evidence quality) and bacteremia (very low evidence quality), respectively, compared with that of vancomycin. Cephalosporins had a higher risk of nausea, whereas linezolid had a higher risk of nausea, diarrhea, and thrombocytopenia than that of vancomycin. Vancomycin posed a higher risk of rash, pruritus, red man syndrome, and nephrotoxicity than that of alternatives.

Conclusions

The quality of evidence supporting the higher efficacy of alternative treatment over vancomycin for MRSA infection was not high. Given varying safety profiles and advancements in therapeutic monitoring, careful consideration of patient‐specific factors and pharmacokinetics is crucial when selecting treatment alternatives to vancomycin.
Refurbishing the marine parasitoid order Pirsoniales with newly (re)described marine and freshwater free‐living predators
Authors: Prokina Kristina I. , Yubuki Naoji , Tikhonenkov Denis V. , Ciobanu Maria Christina , López‐García Purificación , Moreira David
Published: October 2024

Pirsoniales is a stramenopile order composed of marine parasitoids of diatoms with unique life cycle. Until recently, a single genus, Pirsonia, uniting six species, was known. The recent identification of new free‐living eukaryotrophic Pirsoniales Pirsonia chemainus, Feodosia pseudopoda, and Koktebelia satura changed our understanding of this group as exclusively parasitic. However, their cell ultrastructure and feeding preferences were not fully studied due to the death of the cultures. In this study, we re‐isolated some of these Pirsoniales and established six new strains exhibiting predatory behavior, including a first freshwater representative. This allowed us to describe five new genera and species, as well as to emend the diagnosis of the order Pirsoniales. The 18S rRNA gene phylogenetic analysis revealed the position of new strains within Pirsoniales and their relationships with parasitoid relatives and environmental sequence lineages. Feeding experiments on novel Pirsoniales strains using diverse algal prey showed that they were not able to form trophosomes and auxosomes. The ability of cell aggregation in Pirsoniales was observed for the first time. One of the studied strains contained intracellular gammaproteobacteria distantly related to Coxiella. Ultrastructural analyses revealed a more complex cytoskeleton structure in Pirsoniales than previously thought and supported the monophyly of Bigyromonadea and Pseudofungi.
Is single‐port laparoscopy or vaginal natural orifice transluminal endoscopic surgery the better option for salpingo‐oophorectomy?
Authors: Gülseren Varol , Güngördük Kemal , Uyar Berican Şahin , Özdemir İsa Aykut
Published: October 2024

Aim

To compare postoperative pain and recovery in patients undergoing oophorectomy with single‐port laparoscopic surgery (SPLS) versus vaginal natural orifice transluminal endoscopic surgery (vNOTES).

Method

Patients who underwent salpingo‐oophorectomy with SPLS or vNOTES between 2016 and 2023 were analyzed retrospectively. Oophorectomy was performed based on the presence of an adnexal mass or breast cancer susceptibility gene mutation.

Results

Fifty‐two patients underwent oophorectomy with SPLS and 35 underwent vNOTES. Although the mean mass size was slightly larger in the SPLS group than in the vNOTES group (8.0 ± 4.1 vs. 6.8 ± 3.3 cm), the difference was not significant. There was no difference in operating times between SPLS and vNOTES. The mean visual analog scale and faces pain scale scores 2 and 6 h postoperatively were lower in the vNOTES group. The mean quality of recovery‐40 (QoR‐40) score was higher in the vNOTES group (156 ± 14 vs. 148 ± 11; p = 0.009). This analysis identified vNOTES as an independent predictor of a high QoR‐40 score.

Conclusion

The vNOTES group experienced less pain during the early postoperative period than the SPLS group. Although the operating and removal times were similar, the port setup time was longer for the vNOTES group.
Is there a mental health wake following the COVID‐19 pandemic on adolescents in a male juvenile prison?
Authors: Fix Rebecca L. , Thompson Kelli R. , Doan Brandon
Published: October 2024

Lingering effects of the COVID‐19 pandemic loom large in the United States but are particularly of concern in prison settings. In the current study, we examine the ongoing mental health consequences of the pandemic among young people incarcerated in a male juvenile prison. Sequential mixed methods data were obtained—78 young people assigned male at birth completed surveys and 19 completed individual interviews. Seven staff were also interviewed about youth experiences during and following the pandemic. Youth survey results indicated racial and ethnic identity exploration, feeling less safe at night, and experiencing staff harassment were significantly associated with some negative mental health concerns, yet lingering COVID‐19 policies were not. Triangulation with interviews underscored these findings by highlighting more specific concerns related to COVID‐19, such as social isolation, loneliness, and concerns about the indirect effects the pandemic might have on court outcomes and educational goals. Overall, results of the current analysis provide evidence that incarceration continues to be traumatizing and harmful to youth mental health even following the pandemic. To a lesser extent, these results also imply that lingering effects of the pandemic and concurrent cultural and racial tensions have delayed impacts on the mental health of incarcerated youth during this tumultuous time. Taken together, study findings suggests juvenile prisons must implement readiness plans to mitigate these and other harmful effects of juvenile incarceration in the future.
Trends in psychosocial research on LGBTIQ+ populations in Latin America: Findings, challenges, and concerns
Authors: Barrientos Jaime , Nardi Henrique Caetano , Mendoza‐Pérez Juan Carlos , Navarro María Camila , Bahamondes Joaquín , Pecheny Mario , Radi Blas
Published: October 2024

Psychosocial research on lesbian, gay, bisexual, transgender, intersex, and queer (LGBTIQ+) populations from Latin America is relatively recent. Initially, research focused mainly on prejudice, using qualitative techniques. Studies on LGBTIQ+ populations, using more sophisticated psychosocial theories such as those of Herek or Meyer, began in the mid‐1990s. This study deals with surveys and scales based on non‐probabilistic samples, LGBTIQ+ populations being the first studied. In the early 2000s, queer and/or LGBTIQ+ theories were introduced, and research has been much more interdisciplinary. This paper describes the theoretical frameworks used in LGBTIQ+ research in Latin America and examines distinctions in the findings from Mexico, Colombia, Chile, Argentina, and Brazil. Future research must involve cross‐cultural studies, systematic or scoping reviews, and studies on non‐binary populations. Finally, the conditions for reimaging LGBTIQ+ research in Latin America are discussed.
A systematic PCR record‐based re‐call of HCV‐RNA‐positive people enables re‐linkage to care and HCV elimination in Austria — The ELIMINATE project
Authors: Balcar Lorenz , Schwarz Michael , Dorn Livia , Jachs Mathias , Hartl Lukas , Weseslindtner Lukas , Pfisterer Nikolaus , Hennlich Barbara , Stückler Annika , Strassl Robert , Voill‐Glaninger Astrid , Hübl Wolfgang , Willheim Martin , Köhrer Karin , Jansen‐Skoupy Sonja , Tomez Sabine , Krugluger Walter , Madl Christian , Burghart Lukas , Antonitsch Lukas , Weidinger Gerhard , Riedl Florian , Laferl Hermann , Hind Julian , Wenisch Christoph , Sebesta Christian , Wachter‐Welzl Julia , Watzl Paul , Neuhauser Magdalena , Chromy David , Mandorfer Mattias , Schmid Daniela , Gschwantler Michael , Reiberger Thomas , Maieron Andreas , Bauer David J.M. , Schwarz Caroline
Published: October 2024

Background and Aims

Identification of people living with hepatitis C virus (HCV) via readily available laboratory records could be a key strategy for macro‐elimination, aligning with the WHO elimination goal. Therefore, the ELIMINATE(ELIMINation of HCV in AusTria East) project aimed to systematically re‐link people with a ‘last‐positive’ HCV‐RNA PCR record to care.

Methods

In 10 major liver centres in Eastern Austria, a systematic readout of ‘last‐positive’ HCV‐RNA PCR test records obtained between 2008 and 2020 were conducted and linked to available patient contact data. Between 2020 and 2023, individuals were contacted first by phone, then by letter, to inform them about the availability of effective direct‐acting antiviral (DAA) treatment and invite them for pre‐treatment evaluation.

Results

The overall cohort of last‐positive HCV+ individuals included 5695 subjects (62.5% males, mean age 57.3 ± 17.3 years); of note, 1931 (34%) of them had died and 759 (13%) individuals had no valid contact information. Of the remaining 3005 individuals, 1171 (40.0%) had already achieved sustained virological response (SVR) at the time of re‐call. We successfully reached 617 (20.5%), of whom 417 (67.6%) attended their pre‐treatment visit, and 397 (64.3%) commenced DAA‐therapy. HCV cure has been confirmed in 326 individuals, corresponding to an SVR rate of 82.1%.

Conclusion

The ELIMINATE project identified 5695 people living with HCV who were ‘lost to care’ despite documented HCV viraemia. While invalid contact data were an evident barrier to HCV elimination, premature deaths among the cohort underscored the severity of untreated HCV. The implementation of a systematic HCV‐RNA PCR recorded‐based re‐call workflow represents an effective strategy supporting the WHO goal of HCV elimination.
Renin‐angiotensin blockade ameliorates the progression of glomerular injury in podocyte‐specific Ctcf knockout mice
Authors: Fujioka Keisuke , Nagai Takashi , Hattori Tomoki , Kagami Shoji , Yasutomo Koji , Galjart Niels , Hirayama Teruyoshi , Kawachi Hiroshi , Urushihara Maki
Published: October 2024

Aim

Several studies have shown that the progression of proteinuria and renal tissue injury is associated with activation of the intrarenal renin‐angiotensin system (RAS). CCCTC‐binding factor (CTCF) is a DNA‐binding factor that plays an essential role in the regulation of gene expression. In the present study, we aimed to investigate the phenotypic effects of CTCF deficiency in podocytes.

Methods

Angiotensin II type 1 receptor blockers (ARBs) were administered to the podocyte‐specific Ctcf knockout mice, and histological and biochemical analyzes were performed. We also investigated the changes in the expression of podocin in podocyte cell cultures with or without stimulation with angiotensin II from glomeruli isolated using magnetic beads from podocyte‐specific Ctcf knockout mice.

Results

Mice in which Ctcf was deleted from podocytes developed glomerulopathy and mice developed severe progressive proteinuria, and impaired renal function. Moreover, ARBs suppressed the development of glomerulopathy in podocyte‐specific Ctcf knockout mice. Both real‐time polymerase chain reaction and western blotting showed that podocin expression was decreased in cell cultures stimulated with angiotensin II. Furthermore, RAS components gene expressions in podocyte cell cultures isolated from podocyte‐specific Ctcf knockout mice were significantly increased.

Conclusion

These results suggest that RAS is involved in the development of glomerulopathy in podocyte‐specific Ctcf knockout mice. Elucidation of the pathophysiology of podocyte‐specific Ctcf knockout mice may provide new insights into the relationship between podocyte injury and chronic glomerulonephritis.

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Microscopical anatomy of the peripheral nervous system: An essential notion for understanding the pathophysiology of very early classic Guillain‐Barré syndrome
Authors: Berciano José
Published: October 2024

The aim of this paper is to analyze the pathophysiological mechanisms acting in very early classic Guillain‐Barré syndrome (GBS) (≤4 days of symptomatic onset). In this inaugural period, both in GBS and its animal model, experimental autoimmune neuritis, the outstanding pathological feature is inflammatory edema predominating in proximal nerve trunks, particularly spinal nerves, and possibly in preterminal nerve segments. Nerve trunks external to the subarachnoid angle possess epi‐ perineurium that is relatively inelastic and of low compliance. Here such edema can increase endoneurial fluid pressure that, when sufficiently critical, may stretch the perineurium and constrict transperineurial microcirculation, compromising blood flow and producing the potential for ischemic nerve injury, whose consequence is rapid partial or complete loss of nerve excitability. These histopathological features correlate well with electrophysiological and imaging findings reported in early GBS stages. Spinal nerve edema and ischemia help to understand the pattern of Wallerian‐like degeneration observed in the axonal form of GBS, predominating in motor spinal roots at their exit from the dura matter (spinal nerves) with centrifugal distribution in more distant motor nerve trunks, and centripetal extension to the distal portion of intrathecal roots. The similarity of initial pathogenic mechanisms between demyelinating and axonal forms of GBS explains why an early increase of serum biomarkers of axonal damage is detected in both forms. In conclusion, knowledge of the microscopic anatomy of the peripheral nervous system is an essential step for a reliable understanding of pathophysiological mechanisms operating in the early phase of any classic GBS subtype.
Exploring the Utility of a Novel Approach of Evaluating Application of a Validated Violence Risk Assessment Instrument
Authors: Maguire Tessa , Daffern Michael , Willetts Georgina , McKenna Brian
Published: October 2024

Mental health nurses are often responsible for assessment/management of inpatient aggression. Validated instruments such as the Dynamic Appraisal of Situational Aggression (DASA), can aid risk assessment. However, limited attention has been paid to evaluating nurses' ability to administer risk assessment instruments. An entrustable professional activity may offer way of evaluating risk assessment clinical activities. DASA trainers' perceptions of the value and utility of an EPA were explored via collection of data through focus groups, with 17 participants from six countries. Thematic analysis was conducted to analyze the data. Three themes were interpreted: (1) DASA trainers‐a way of knowing and being (2) An EPA‐something you did not know you need until you see it; (3) The DASA‐EPA supports the need for training and importance of integrity in assessment. Trainers engaged in innovative ways to ensure training is suitable and responsive to needs of nurses and their setting. Participants understood how an EPA could be used to evaluate DASA administration, monitor DASA use, provide feedback, and highlight the importance of training to ensure best practice.
Widespread plant species temporal variation along environmental and microclimate gradients in Norwegian mountains in a climate change context
Authors: Wehn Sølvi , Isaksen Ketil , Johansen Line
Published: October 2024

The effect of climate change on mountain vegetation is influenced by environmental factors and site effects. To monitor the effect of climate change we therefore need to understand species' sensitivity to microclimate and environmental gradients. The objective of this study is to study widespread plant species' temporal and spatial variation along environmental and microclimate gradients in Norwegian mountains along a coast–inland gradient. Occurrence and abundance of plant species were surveyed in 110 study plots in four mountains at two points in time, seven years apart. Of the 222 plant species registered, Salix herbacea, Phyllodoce caerulea, Carex bigelowii, Juncus trifidus, Vaccinium myrtillus, Avenella flexuosa, and Empetrum nigrum were widespread across all mountains. These species responded differently to environmental and microclimate gradients, and abundance data were more sensitive than occurrence data. During the short time span we observed some indications of response which might support the assumption that boreal species outcompete alpine species in the forest transition zone, but our data do not indicate this effect at higher altitudes. Monitoring of climate change in mountains needs to include plots along environmental and microclimate gradients as well as an abundance of a set of widespread plant species that represent regional, local environmental, and climate gradients. However, when monitoring perennial plant species, the need for long‐term monitoring projects is high because such species develop slowly over several decades.
Allium taiseba, a new species of Allium sect. Scorodon (Amaryllidaceae) from Van province (Turkey)
Authors: Fırat Mehmet
Published: October 2024

A new species, Allium taiseba (A. sect. Scorodon), is described from Hoşap (Xoşap)/Van province, Turkey. It is morphologically similar to A. bingoelense, but it differs in several morphological features including inner tunic's colour of bulb, spathe length, tepal colours and size, stamen colour and length, ovary shape, style colour and length, capsule and seeds size. A comprehensive description of the new species is provided, including detailed photographs, geographical distribution map, habitat and ecology, vernacular names and IUCN conservation status.
Gastrodia lohitensis sp. nov. (Orchidaceae, Epidendroideae) from India
Authors: Chowlu Krishna , Tsering Jambey , Ray Ajit , Rao Abbareddy Nageswara , Pertin Abing , Dash Sudhansu Sekhar , Kabeer Altaf
Published: October 2024

A new mycotrophic species of the genus Gastrodia (Orchidaceae), is described and illustrated from Arunachal Pradesh, India. The species is unique within the genus in having two oblong–linear calli which are parallelly arranged along the margins of the claw of the labellum, and white flowers. The new species is assessed as 'Endangered' according to the IUCN red list criteria.
Development and clinical application of bioelectrical impedance analysis method for body composition assessment
Authors: Son Jang Won , Han Byoung‐Duck , Bennett Jonathan P. , Heymsfield Steve , Lim Soo
Published: October 2024

Obesity, which is characterized by excessive body fat, increases the risk of chronic diseases, such as type 2 diabetes, cardiovascular diseases, and certain cancers. Sarcopenia, a decline in muscle mass, is also associated with many chronic disorders and is therefore a major concern in aging populations. Body composition analysis is important in the evaluation of obesity and sarcopenia because it provides information about the distribution of body fat and muscle mass. It is also useful for monitoring nutritional status, disease severity, and the effectiveness of interventions, such as exercise, diet, and drugs, and thus helps assess overall health and longevity. Computed tomography, magnetic resonance imaging, and dual‐energy X‐ray absorptiometry are commonly used for this purpose. However, they have limitations, such as high cost, long measurement time, and radiation exposure. Instead, bioelectrical impedance analysis (BIA), which was introduced several decades ago and has undergone significant technological advancements, can be used. It is easily accessible, affordable, and importantly, poses no radiation risk, making it suitable for use in hospitals, fitness centers, and even at home. Herein, we review the recent technological developments and clinical applications of BIA to provide an updated understanding of BIA technology and its strengths and limitations.
Clinical Outcomes of Full‐Endoscopic Visualized Foraminoplasty and Discectomy for Lumbar Disc Herniation with Bilateral Radiculopathy
Authors: Shi Changgui , Wu Lecheng , Tang Guoke , Sun Bin , Xu Ning , Lin Wenbo , Liu Jia , Xu Guohua
Published: October 2024

Objective

The treatment of lumbar disc herniation (LDH) with bilateral radiculopathy using transforaminal endoscopic lumbar discectomy (TELD) remains challenging, especially at the L5/S1 level with narrow foramen or high iliac crest. Full‐endoscopic visualized foraminoplasty and discectomy (FEVFD) is a newly developed technique for LDH and lumbar stenosis. However, there is limited evidence on the efficacy of FEVFD technique in the treatment of LDH with bilateral radiculopathy. This study was to assess the clinical outcomes and safety of using FEVFD in the treatment of LDH with bilateral radiculopathy.

Methods

This retrospective study enrolled 63 patients with LDH presenting with bilateral radiculopathy between January 2018 and January 2022. Patients enrolled before January 2020 were treated using a conventional transforaminal endoscopic surgical system (TESSYS) technique (TESSYS, n = 33) and treated using a FEVFD technique after that (FEVFD, n = 30). The total operation time and the number of intraoperative fluoroscopies were recorded. The Oswestry Disability Index (ODI) and visual analog scale (VAS) were evaluated preoperatively and postoperatively (at 1‐month, 3‐month, 6‐month, and final follow‐ups). Global outcomes at final follow‐up were assessed using modified MacNab criteria.

Results

Compared with TESSYS, patients in FEVFD group had a shorter operation time (92.9 vs. 78.0 min). The intraoperative fluoroscopies in FEVFD group were significantly lower than those in TESSYS group (18.7 vs. 4.9). After the operation, the VAS and ODI scores at all follow‐ups in the two groups were significantly lower than those before operation. For the L5/S1 level, the values of VAS and ODI scores in FEVFD group were significantly lower than those of in TESSYS group at 3‐month, 6‐month, and final follow‐up. For the L4/5 level, however, no significant difference was found in VAS and ODI scores between these two groups at the follow‐ups. According to the modified MacNab criteria, the excellent‐to‐good rate in TESSYS and FEVFD groups was 84.8% and 90.0%, respectively.

Conclusion

For LDH with bilateral radiculopathy, using the FEVFD technique could not only reduce the operation time and radiation, but also improve the clinical outcomes at the L5/S1 level.
Complicated Spinal Stenosis and Spinal Deformity in Patients with Achondroplasia: Case Series and Review of the Literature
Authors: Fu Wenyang , Gao Xianlei , Wang Xia , Xu Rongkun , Li Shangye , Wang Lianlei , Liu Xinyu
Published: October 2024

Objective

Due to the low incidence of achondroplasia (Ach), there is a relative lack of research on the treatment and management of spinal complications of Ach. Characteristics and interventions for spinal complications in patients with Ach are in urgent need of investigation. This study aimed to summarize the common spinal complications in patients with Ach and the corresponding treatment strategies.

Methods

This study is a retrospective case series. We retrospectively collected and analyzed Ach cases who presented to our hospital with neurological symptoms due to skeletal anomalies between February 2003 and October 2023. A total of seven patients were included, four males (57.1%) and three females (42.9%) with a mean age of 38.57 years. Patient pain/numbness visual analog scale (VAS), preoperative Oswestry disability index (ODI), development of neurological complaints, and presentation of skeletal abnormalities were collected and followed up routinely at 3, 6, 12 and 24 months postoperatively. The relevant literature was reviewed.

Results

Seven patients were included in this series. The mean preoperative VAS was 4, and the mean preoperative ODI was 50.98%. All patients had concomitant spinal stenosis, four with thoracolumbar kyphosis (TLK), and one with scoliosis. Six of the seven patients underwent surgery, and one patient received conservative treatment. In the routine follow‐ups, all patients experienced satisfactory relief of symptoms. Only one of the seven patients developed a new rare lesion adjacent to the primary segments. Six months after the first surgery, a follow‐up visit revealed thoracic spinal stenosis caused by ossification of the ligamentum flavum, and his symptoms were relieved after thoracic decompression surgery.

Conclusions

Ach seriously affects the skeletal development of patients and can lead to the development of spinal stenosis, spinal deformities, and other complications of the locomotor system. Surgery remains the primary treatment for complications of the musculoskeletal system. Specific surgical approaches and comprehensive, long‐term management are critical to the treatment of patients with spinal complications.
Respiratory dysfunction in childhood cancer survivors: A single institution study
Authors: Fukushima Hiroko , Suzuki Ryoko , Yamaki Yuni , Hosaka Sho , Inaba Masako , Kido Takahiro , Masumoto Kouji , Muroi Ai , Suzuki Hideo , Takada Hidetoshi
Published: October 2024

Background

Recently, while the overall survival rate of childhood cancer has improved, research has highlighted a high incidence of comorbidities in childhood cancer survivors (CCSs). However, it is likely that many asymptomatic comorbidities go unnoticed. The purpose of the current study was to identify comorbidities unique to Japanese CCSs through comparisons with a general population that underwent comparable comprehensive medical checkups.

Methods

The patient group included CCSs who had completed their cancer treatment, were aged 16 years or older, and underwent the comprehensive medical checkups at the University of Tsukuba Hospital between 2018 and 2020. The control group included members of the general population who underwent comprehensive medical checkups at the same hospital in 2018.

Results

Seventeen CCSs and 59 controls were included. Among the CCSs, the median ages at medical checkup and diagnosis were 22.1 years (range, 16–39) and 8.7 years (range, 1.3–14.8), respectively. Incidence of abnormalities in respiratory function, hearing function, and body mass index was higher in CCSs (52.9%, p = 0.013; 17.6%, p < 0.001; and 41.2%, p = 0.080, respectively) compared with controls.

Conclusion

Asymptomatic pulmonary dysfunction was detected in the comprehensive medical checkup as a unique comorbidity in CCSs. Because the odds ratio of mortality due to respiratory failure is high in CCSs, as previously reported, we believe that detection of pulmonary dysfunction and the promotion of a healthy lifestyle are important. The evaluation of the pulmonary function may not typically be included in routine clinical visits, but it could be necessary for comprehensive medical evaluation in CCSs.
Towards a new generation of fluvial facies models for the interpretation of ancient deposits, based on inter‐annual peak discharge variance of modern rivers
Authors: Fielding Christopher R. , Alexander Jan , Argiro Adam
Published: October 2024

Fluvial facies models based on river planform are flawed and not fully fit for purpose. An alternative approach to classifying fluvial deposits is based on river discharge characteristics. A recent paper showed that the co‐efficient of variance of annual peak discharge (CVQp) correlates well with the characteristics of preserved alluvium for a suite of modern rivers. Here, the database of rivers is expanded and augmented, and the utility of this statistic confirmed. For modern rivers, plotting the running‐value of CVQp for a set interval (for example, 30 years) over a longer discharge record shows that the statistic varies both spatially and temporally. The CVQp can rise abruptly at a given location in response to a single flow event if that event is significantly larger than is common in that river. Such abrupt changes in CVQp are superimposed on longer‐term patterns of more gradual change stimulated by environmental factors or anthropogenic effects such as dam construction. If the period of calculation for CVQp is relatively short, ‘anomalous’ events appear more frequently. Sequential studies of modern rivers indicate that such anomalous events have a high probability of being preserved in the alluvial record of the river, and suggest that, over the timeframes of channel filling and abandonment, they may constitute the dominant (characteristic) portion of the record in high CVQp systems. Since flow events with strongly peaked hydrographs (flashy discharges) are more common in high CVQp systems and leave a record dominated by upper flow regime stratification styles, it follows that the alluvial record of high CVQp rivers will be dominated by upper flow regime stratification. In contrast, in lower CVQp systems the occurrence of an event that changes the running CVQp value significantly may form a distinct event deposit, and the temporarily changed CVQp is unrepresentative for the duration of the channel's life. The dominance of upper flow regime stratification, together with decreased preservation of identifiable macroform structure, increased lateral lithological heterogeneity, and in many cases increased preservation of in situ tree fossils in channel deposits of higher CVQp rivers, forms the basis for a series of new facies models for low, moderate, high and very high/ultra‐high CVQp alluvial systems and deposits. The new models can be applied to ancient successions either in combination with traditional, planform‐based models, or not. These models provide information about ancient palaeoenvironmental conditions, and changes in such conditions over time at various scales via stratigraphic investigations.
Three Philosophies of Person‐Centred Care, From the Perspectives of Care Workers and Managers Supporting Older People
Authors: Lombard Daniel
Published: October 2024

The prominence of person‐centred care has been widely recognised in recent decades. In England, care governance frameworks prioritise the views and wishes of individual people receiving support. Despite workforce development initiatives linked to this agenda, there remains no consensus on the meaning of person‐centred care in the English care sector. An actor‐centred study explored understandings of person‐centred care from the perspective of care workers and managers working with older people in residential and community care. Analysis of interviews with 20 participants led to development of a typology based on the beliefs, values and practices of the interviewees. The three typological groups interpreted person‐centred care within their own distinctive philosophies: Nurturing Mental Health, Nurturing Agency and Nurturing Intimacy. The findings offer fresh insight into the ways an abstract concept is understood within the context of day‐to‐day practice with older people. Existing workforce development guidance encourages professionals to understand person‐centred care by enacting a series of wide‐ranging, desirable outcomes, which is potentially confusing for those working on the front line. This study shows, instead of trying to be all things to all people, staff emphasise a few specific outcomes and values in enacting person‐centred care, reflecting nuances in their overall understanding of older people's well‐being.
Involvement of Sex Hormones and Their Receptors in the Pathogenesis of Classic Kaposi's Sarcoma in Xinjiang
Authors: Wei Meng , Jiang Xin , Bian Yi , Fan Jun‐Wei
Published: October 2024

Objective

This study aims to examine the expression of androgen receptor (AR) and estrogen receptor (ER) in patients with classic Kaposi's sarcoma (CKS) in Xinjiang, as well as to assess the serum levels of sex hormones in these patients. The objective is to explore potential new directions and targets for diagnosing and treating CKS in Xinjiang.

Methods

The case group comprised 35 patients diagnosed with CKS who presented at our hospital from 2014 to 2021. The control group consisted of 35 patients with pyogenic granuloma (PG) who visited the hospital during the same period, selected using propensity score matching (PSM). Immunohistochemistry was used to detect AR, human herpesvirus type 8 (HHV‐8), and ER in paraffin‐embedded tissue samples from patients diagnosed with CKS and PG. Additionally, enzyme‐linked immunosorbent assay (ELISA) was used to quantitatively measure serum sex hormone levels in the 35 patients with CKS and 35 patients with PG.

Results

AR expression was relatively weak in both the CKS and PG groups, with the PG group exhibiting a slightly stronger expression than the CKS group. Conversely, the expression of ER was significantly higher in the CKS group compared to the PG group (p < 0.05). Additionally, serum testosterone (T) levels were elevated in the CKS group, while serum estradiol (E2) levels were higher in the PG group (p < 0.05).

Conclusion

Sex hormones and their receptors are implicated in the pathogenesis of CKS in Xinjiang. The use of ER antagonists may represent a novel avenue for research and treatment of CKS.
Schooling in camp: Incarceration camps and the Japanese American school experience during World War II
Authors: Tsou Tzung‐Ruei
Published: October 2024

Objective

This study aims to explore the school experiences of Japanese American children and teenagers who were incarcerated in camps during World War II following the issuance of Executive Order 9066 on February 19, 1942.

Methods

The study examines video interviews available in Densho's online archive, focusing on the educational experiences of second‐generation Japanese Americans who resumed their education in the camps.

Results

The analysis reveals that many interviewees reported positive experiences in camp schools, despite the poor conditions. A key factor contributing to these positive experiences was the dedication of teachers, who not only promoted academic success but also addressed the psychological and emotional needs of the incarcerated students.

Conclusion

While many interviewees highlighted the supportive role of teachers, the negative effects of incarceration on their school experiences cannot be overlooked, as a significant number recalled unpleasant aspects of their education in the camps. Moreover, the incarceration of Japanese Americans still has contemporary implications.
Unbounding the future: New directions for climate‐changed geographies
Authors: Cox Savannah
Published: October 2024

This commentary reflects on the contributions that human geography has made to climate change research, as well as future directions for human geographic work on climate change. I suggest that one of the key achievements of the field is to render climate change a boundary object: an entity whose interpretive flexibility allows it to become a shared object of knowledge that, in principle, facilitates collaboration across disparate communities of practice. However, the ways in which that contribution has been made, and made possible, have effects that ripple elsewhere. While the subfield of political ecology and its historiographical methods have played vital roles in laying the intellectual foundations for human geographic work on climate change, and thus its ability to construct climate change as a boundary object in the first place, I suggest that they and other neo‐Marxian approaches to the study of the (climate‐changing) environment tend to diminish human geographic engagement with the future as an object of scholarly inquiry. To address that limitation and help push climate‐changed geographies in novel directions, I suggest that climate‐changed futures be engaged problematically. I then conclude with a discussion of key empirical domains—chiefly climate reparations and climate adaptation—where such problem‐oriented work may be productively applied.
Ratios of calcium to citrate administration in blood transfusion for traumatic hemorrhage: A retrospective cohort study
Authors: Alghanem Husam , Liu Nathan Chi‐Ping , Gupta Atul , Liao Chuanhong , Wool Geoffrey David , Rubin Daniel Steven , Carll Timothy
Published: October 2024

Background

Massive transfusion with citrated blood products causes hypocalcemia, which is associated with mortality. Recognition of this problem has led to increased calcium administration; however, the optimal dosing is still unknown.

Study Design and Methods

This retrospective, single‐center study included level 1 trauma patients in 2019 and 2020 who underwent an operation within 12 h of arrival and received a transfusion. Preoperative and intraoperative administrations were totaled to calculate the ratio of administered calcium to the number of blood transfusions for each patient. The citrate content of each blood component was estimated to calculate a second ratio, the ratio of administered calcium to administered citrate. Receiver Operating Characteristic (ROC) curves were performed on both ratios to determine the optimal cutoff values for predicting severe hypocalcemia (ionized calcium <0.9 mmol/L) and hypercalcemia (>1.35 mmol/L) at the end of the intraoperative period.

Results

A total of 506 trauma activations were included, receiving a mean of 17.4 citrated blood products and 16.3 mmol of calcium (equivalent to 2400 mg of calcium chloride). No ratio was statistically significant in differentiating severely hypocalcemic patients from the rest. A calcium to blood ratio of 0.903 mmol of administered calcium per citrated blood product differentiated hypercalcemic patients from the rest.

Discussion

Quantifying received calcium and citrated blood products was insufficient to predict severe hypocalcemia, suggesting other contributions to hypocalcemia. We demonstrated an upper‐limit ratio for calcium administration in traumatic hemorrhage; however, further studies are required to determine what calcium dosing regimen results in the best outcomes.
From unwanted to wanted: Blending functional weed traits into weed distribution maps
Authors: Schatke Mona , Ulber Lena , Musavi Talie , Wäldchen Jana , von Redwitz Christoph
Published: October 2024

Site‐specific weed management (SSWM) is increasingly employed to reduce herbicide inputs. Incorporating functional traits of weed species allows for the selection of SSWM methods that effectively reduce the abundance of weeds with a high competitive potential (disservice) while preserving weeds that provide beneficial ecosystem services (service). In this study, we aim to assess relevant weed functional traits and translate this information into a spatial trait distribution map for weed (dis‐)service provision. The distribution of weed abundance in a field was recorded using a spatial grid. Data on functional traits for the recorded weed species were extracted from published datasets and combined into the two variables, service and disservice. Individual traits (service/disservice) were weighted for each pixel of the weed distribution map based on the number of individual plants per species. Principal component analysis was employed to generate independent variables to describe the potential for service and disservice provision. As a result, two (dis‐)service trait‐based distribution maps were generated: one highlights field areas that provide enhanced ecological services, while the other displays areas with a high disservice potential. The results show that around 61% of the area in the field had a high service potential. The area with a high disservice was slightly higher than the half of the area with a high service, while about 32% of the field has both high service and disservice potential in the same area. This study presents a spatially explicit approach to incorporate information on weed functional traits into SSWM approaches targeted at reducing weed competition while at the same time enhancing weed functional diversity.
Bayesian Inference for Estimating Heat Sources Through Temperature Assimilation
Authors: Mousavi Hanieh , Eldredge Jeff D.
Published: October 2024

This paper utilizes a Bayesian inference framework to address the two-dimensional (2D) steady-state heat conduction problem, focusing on the estimation of unknown distributed heat sources in a thermally conducting medium with uniform conductivity. The goal is to infer the locations, strength, and shape of heaters by assimilating temperature data in Euclidean space, employing a Fourier series to represent each heater's shape. The Markov Chain Monte Carlo (MCMC) method, incorporating the random-walk Metropolis–Hasting (MH) algorithm and parallel tempering, is utilized for posterior distribution exploration in both unbounded and wall-bounded domains. It is found that multiple solutions arise in cases where the number of temperature sensors is less than the number of unknown states. Moreover, smaller heaters introduce greater uncertainty in estimated strength. To address the challenge of estimating the heater's strength and shape simultaneously due to their strong correlation, our method incorporates sharp priors on one to ensure accurate and feasible solutions of the other. The diffusive nature of heat conduction smooths out any deformations in the temperature contours, especially in the presence of multiple heaters positioned near each other, impacting convergence. In wall-bounded domains with Neumann boundary conditions, the inference of heater parameters tends to be more accurate than in unbounded domains.