bluuebunny/crossref_metadata_2025 huggingface dataset:
Iron deficiency without anemia in children with newly diagnosed celiac disease: 1-year follow-up of ferritin levels, with and without iron supplementation
Authors: Ben-Ami Tal , Trotskovsky Anna , Topf-Olivestone Chani , Kori Michal
Published: August 2024

Iron deficiency (ID) without anemia is common in children with newly diagnosed celiac disease (CD). We aimed to assess the effect of iron supplementation versus no treatment on ferritin levels in newly diagnosed CD patients with ID adhering to a gluten-free diet (GFD). A retrospective review of children < 18 years, with low ferritin (≤ 10 ng/mL) and normal hemoglobin levels diagnosed between 12.2018 and 12.2021. We compared hemoglobin and ferritin levels between patients who received supplemental iron to those who did not. Data, including demographics, laboratory tests, and anthropometrics, were collected at baseline, and at 6 and 12 months following the initiation of the GFD. Adherence to GFD was assessed at each visit. Among 304 children diagnosed during the study period, 43 (14.1%) had iron deficiency anemia and 60 (19.7%) ID without anemia. Among children with ID, 29 (48%) were female, mean age 7.3 ± 3.9 years. Twenty-nine (48%) children received iron supplementation, and 31 (52%) did not. At the 12-month follow-up visit, tissue transglutaminase levels decreased significantly (p < 0.001), from a mean baseline level of 226.6 ± 47.8 to 34.5 ± 46 U/mL in children that received iron supplementation and from 234.2 ± 52.4 to 74.5 ± 88.7 U/mL in non-treated children, with no significant difference between the groups p = 0.22. Ferritin levels increased significantly (p < 0.001), from 9.0 ± 4.7 to 25.2 ± 20.8 ng/mL in patients who received supplementation and from 8.9 ± 3.8 to18.6 ± 9.5 ng/mL in patients who did not, with no significant difference between the groups (p = 0.46).

Conclusion: Most children with newly diagnosed celiac disease and iron deficiency, who adhere to GFD, will normalize ferritin levels within 12 months without the need of iron supplementation.

What is Known:• Iron deficiency and iron deficiency anemia are common in newly diagnosed celiac disease.• Improved iron absorption may follow mucosal healing process in patients adhering to a strict gluten-free diet.

What is New:• This single-center, retrospective cohort study evaluated the effect of iron supplementation versus no treatment on ferritin levels in children with newly diagnosed celiac disease with iron deficiency adhering to a gluten-free diet.• Most children with newly diagnosed celiac disease and iron deficiency, who adhere to gluten-free diet, will normalize ferritin levels within 12 months without the need of iron supplementation.
Baseline systemic inflammatory indices and clinicopathological features to predict the outcome of acute tubulointerstitial nephritis
Authors: Dirim Ahmet Burak , Namazova Nazrin , Dirim Merve Guzel , Oto Ozgur Akin , Artan Ayse Serra , Hurdogan Ozge , Ozluk Yasemin , Yazici Halil
Published: August 2024

Background

Acute tubulointerstitial nephritis (AIN) is an immune-mediated disorder that can cause acute kidney injury (AKI). We aimed to investigate the characteristics of patients with AIN and predictive factors for treatment response.

Material and methods

In this study, thirty-one patients diagnosed with AIN on kidney biopsy between 2006 and 2021 were included. Baseline clinical, histopathological, and laboratory findings, including complete blood count (CBC), creatinine, erythrocyte sedimentation rate, C‑reactive protein, C3, C4, systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and urinalysis were evaluated. Treatment response, mortality, and creatinine levels at the time of last follow-up were also noted.

Results

The median age was 46 years and 80.6% were female. Median baseline creatinine and proteinuria levels were 4.1 mg/dL and 0.84 gram/day. The median follow-up period was 14 months and 93.5% received immunosuppressives. End-stage kidney disease (ESKD) developed in five patients (16.1%). Renal recovery (creatinine < 1.4 mg/dL) was observed in 17 patients (54.8%). Higher degrees of interstitial fibrosis, tubular atrophy, granuloma formation, global glomerulosclerosis, and higher baseline hemoglobin levels, in addition to a longer interval between first symptom to initiation of immunosuppressives were associated with renal nonrecovery, statistically. Also, patients who progressed to ESKD had higher baseline hemoglobin (p = 0.033) and lymphocyte (p = 0.044) and lower PLR levels (p = 0.016), as well as higher degrees of global glomerulosclerosis (p = 0.014), interstitial fibrosis (p = 0.042), and tubular atrophy (p = 0.030).

Conclusion

Treatment response rates are low for AIN, which may lead to ESKD. Besides chronicity in histopathology specimens, higher baseline hemoglobin levels and lower platelet-to-lymphocyte ratio might be prognostic. Further studies should be conducted on new markers for AIN.
Exploring sex differences in collaborative virtual environments for participation equality and user experience
Authors: Yang Yifan , Zhang Sheng , Sun Xu , Zhang Xingyi , Sun Xiaotong , Jing Ying , Yang Canjun
Published: August 2024

Communication technology plays a crucial role in facilitating remote collaborative work. This study investigated sex differences in Perceived Participation Equality and User Experience across different communication formats, i.e., face-to-face communication, conventional video conferences, and Virtual Reality (VR). An empirical study was conducted involving 15 groups, each comprising three participants, who engaged in a decision-making task. A research model was developed to evaluate the interplay between perceived participation equality, empathy, and immersion. This model was employed across three communication conditions and included both male and female participants. These findings on sex differences in user experience could help create a connected, cohesive, and productive remote collaborative work environment.
Possibilities and challenges for converting waste biomass into fuel, feed, and fertilizer in Nepal
Authors: Kafle Sagar , Gyawali Manoj , Adhikari Sushil , Kropp Jürgen P. , Pradhan Prajal
Published: August 2024

Waste biomass is mainly used conventionally, without being converted into valuable products in developing countries, e.g., Nepal, mainly due to a lack of proper conversion knowledge, infrastructure, and resource data. We assessed the amount of biomass at sub-national (geography, province, and district) levels in Nepal to explore its conversion possibilities and challenges. Our assessment includes waste biomass such as agriculture crop residues, municipal waste, livestock, and human waste. We identified their current utilization practices and discussed their conversion possibilities, focusing on fuel, feed, and fertilizers. We estimated that about 1.7–5.0 million tonnes (Mt) of pellet/briquette and biochar, 1.7–5.1 Mt of feed block, 129–387 million m3 of biogas, and 0.6–1.9 Mt of fertilizer can be produced in Nepal. The conversion of the waste biomass into valuable products can have significant environmental and economic benefits. Our findings can help authorities formulate appropriate policies and entrepreneurs to develop business plans for proper biomass utilization in Nepal at national and subnational levels.
Personalized computational electro-mechanics simulations to optimize cardiac resynchronization therapy
Authors: Capuano Emilia , Regazzoni Francesco , Maines Massimiliano , Fornara Silvia , Locatelli Vanessa , Catanzariti Domenico , Stella Simone , Nobile Fabio , Greco Maurizio Del , Vergara Christian
Published: August 2024

In this study, we present a computational framework designed to evaluate virtual scenarios of cardiac resynchronization therapy (CRT) and compare their effectiveness based on relevant clinical biomarkers. Our approach involves electro-mechanical numerical simulations personalized, for patients with left bundle branch block, by means of a calibration obtained using data from Electro-Anatomical Mapping System (EAMS) measures acquired by cardiologists during the CRT procedure, as well as ventricular pressures and volumes, both obtained pre-implantation. We validate the calibration by using EAMS data coming from right pacing conditions. Three patients with fibrosis and three without are considered to explore various conditions. Our virtual scenarios consist of personalized numerical experiments, incorporating different positions of the left electrode along reconstructed epicardial veins; different locations of the right electrode; different ventriculo-ventricular delays. The aim is to offer a comprehensive tool capable of optimizing CRT efficiency for individual patients. We provide preliminary answers on optimal electrode placement and delay, by computing some relevant biomarkers such as $$dP/dt_{max}$$

d
P
/
d

t

max

, ejection fraction, stroke work. From our numerical experiments, we found that the latest activated segment during sinus rhythm is an effective choice for the non-fibrotic cases for the location of the left electrode. Also, our results showed that the activation of the right electrode before the left one seems to improve the CRT performance for the non-fibrotic cases. Last, we found that the CRT performance seems to improve by positioning the right electrode halfway between the base and the apex. This work is on the line of computational works for the study of CRT and introduces new features in the field, such as the presence of the epicardial veins and the movement of the right electrode. All these studies from the different research groups can in future synergistically flow together in the development of a tool which clinicians could use during the procedure to have quantitative information about the patient’s propagation in different scenarios.
Assessing climate change threats to biodiversity and protected areas of Iran
Authors: Rahimi Ehsan , Dong Pinliang , Ahmadzadeh Faraham , Jung Chuleui
Published: August 2024

Our research endeavors to evaluate the precise ramifications of climate change on Iran’s protected regions, utilizing species distribution modeling to anticipate the effects of climate change on 394 bird species, 157 plant species, 72 reptiles, and 20 mammals across two climate change scenarios: SSP245 and SSP585 in 2070. Subsequently, we employed binary species distribution maps to determine the extent of overlap between 125 protected areas, 27 wildlife refuges, and 15 national parks and species distribution, quantifying the proportion of these areas encompassed by their distribution. We found that under the SSP585 scenario, 174 bird species could experience a 319% expansion in suitable habitats, while 220 species could decline by 57.1%. Among plants, 16 species are projected to grow by 40.3%, whereas 141 species may decrease by 68.8%. Reptiles could experience an increase of 279.1% in 24 species, with a 66.6% decrease in 48 species, while mammals may witness a significant increase of 147.3% in 5 species, but a 71.8% decrease in 15 species. Also, under the SSP585 scenario, in national parks, bird coverage declines from 32.2% (current) to 19.9%, plants from 24.2 to 13.2%, reptiles from 18.4 to 6.8%, and mammals from 17.7 to 10%. In wildlife refuges, birds decrease from 9.7 to 5.7%, plants from 10.9 to 4.6%, reptiles from 12.9 to 2.5%, and mammals from 7.4 to 4.3%. In protected areas, birds drop from 29.3 to 20.4%, plants from 27.7 to 12.5%, reptiles from 18.7 to 9.7%, and mammals from 24 to 12.1%. The low overlap of species with national parks, wildlife refuges, and protected areas underscores the importance of re-evaluating and potentially expanding protected areas to ensure they encompass a broader range of habitats, particularly those that are underrepresented, to enhance the conservation of Iran’s biodiversity amidst the challenges posed by climate change.
Study demands and health status among medical students in two German universities
Authors: Voss Amanda , Dettmer Susanne , Tschorn Mira , Zoellick Jan C.
Published: August 2024

Aim

Medical students regularly report high study demands and low mental health. Both demands and mental health can be influenced by the curricular structure of degree programmes. We thus studied medical students in two different curricula in Germany, investigating their study demands, study and life satisfaction, and overall and mental health, with emphasis on contrasting beginners and advanced students.

Subject and methods

We used online surveys with convenience samples through university mailing lists and student union channels. Uni1 participants (N = 357; 70% female; M = 24.83 years) were older than Uni2 participants (N = 126; 79% female; M = 23.39 years), but the cohorts did not differ further regarding sociodemographic variables. The main outcomes were study demands on six dimensions, study and life satisfaction, and overall and mental health. For analyses, we used t-tests for comparisons and correlations for associations.

Results

Students of both universities reported good mental and overall health as well as high satisfaction with their studies and lives, although sleep difficulties were prevalent. Study demands were low to medium, with the highest demands being learning activities (M = 5.31; SD = 2.19, scale 0–10), self-structuring (M = 4.61; SD = 2.01), and performance pressure (M = 4.45; SD = 2.27). The students in the reformed degree programme reported fewer issues with integrating theory and practice than those in the regular degree programme (MUni1 = 3.38; SDUni1 = 2.05; MUni2 = 4.17; SDUni2 = 2.06; t(430) = −3.53, p < .001).

Conclusion

Our sample was rather resilient regarding mental health and coping with study demands. The two universities showed little to no differences. With relative increased demands regarding learning activities, self-structuring, and performance pressure, we suggest focusing on learning strategies for beginners and strategies for stress reduction to address, among other things, the reported sleep difficulties.
Families of annihilating skew-selfadjoint operators and their connection to Hilbert complexes
Authors: Pauly Dirk , Picard Rainer
Published: August 2024

In this short note we show that Hilbert complexes are strongly related to what we shall call annihilating sets of skew-selfadjoint operators. This provides for a new perspective on the classical topic of Hilbert complexes viewed as families of commuting normal operators.
5-Aminolevulinic acid-mediated photodynamic therapy in combination with kinase inhibitor lapatinib enhances glioblastoma cell death
Authors: Chandratre Sharayu , Merenich Daniel , Myers Kenneth , Chen Bin
Published: August 2024

5-Aminolevulinic acid (ALA) is an intraoperative imaging agent approved for protoporphyrin IX (PpIX) fluorescence-guided resection of glioblastoma (GBM). It is currently under clinical evaluation for photodynamic therapy (PDT) after the completion of GBM surgery. We previously showed that lapatinib, a clinical kinase inhibitor of epidermal growth factor receptor 1 & 2 (EGFR and HER2), enhanced PpIX fluorescence in a panel of GBM cell lines by blocking ABCG2 (ATP-binding cassette super-family G member 2)-mediated PpIX efflux, which suggests its potential for improving ALA for GBM surgery and PDT. Here we show that lapatinib enhanced PDT-induced cytotoxicity by promoting GBM cell death with the induction of apoptosis followed by necrosis. While the induction of tumor cell apoptosis was massive and rapid in the H4 cell line with no detectable Bcl-2 and a low level of Bcl-xL, it was delayed and much less in extent in A172, U-87 and U-118 cell lines with higher levels of pro-survival Bcl-2 family proteins. Lapatinib treatment alone neither reduced GBM cell viability nor had any significant effect on EGFR downstream signaling. Its enhancement of ALA–PDT was largely due to the increase of intracellular PpIX particularly in the mitochondria, resulting in the activation of mitochondria-mediated apoptosis in H4 cells. Our present study demonstrates that lapatinib inhibits ABCG2-mediated PpIX efflux and sensitizes GBM cells to ALA–PDT by inducing tumor cell death.
Scale dimensions in public participation GIS: an overview for planning and research
Authors: Kajosaari Anna
Published: August 2024

Questions of spatial scale infiltrate Public Participation GIS (PPGIS) in multiple phases of the data collection from the design of a PPGIS survey to the use of the produced spatial knowledge. This paper provides an overview on how spatial scale and scale effects influence the use of PPGIS tools and the validity and usability of the spatial data they produce. The paper approached scale from two complimentary perspectives: as a concept in human geography and as an attribute of cartographic representation in geographic information science. This discussion is organized around three main viewpoints on scale and PPGIS, namely (1) scale in data collection denoting the geographic extent of the study area and the study population, (2) scale in survey design manifested in technical issues, cartographic representation, usability, and design of the mapping activities, and (3) scale and scale effects in the analysis of PPGIS data and the production of spatial knowledge. Together, these views on scale outline the main scale-related issues to consider when planning a PPGIS survey or working with secondary PPGIS data.
The Immunomodulatory Effect of Silver Nanoparticles in a Retinal Inflammatory Environment
Authors: Palacka Katerina , Hermankova Barbora , Cervena Tereza , Rossner Pavel , Zajicova Alena , Uherkova Eva , Holan Vladimir , Javorkova Eliska
Published: August 2024

Abstract

Activation of immune response plays an important role in the development of retinal diseases. One of the main populations of immune cells contributing to the retinal homeostasis are microglia, which represent a population of residential macrophages. However, under pathological conditions, microglia become activated and rather support a harmful inflammatory reaction and retinal angiogenesis. Therefore, targeting these cells could provide protection against retinal neuroinflammation and neovascularization. In the recent study, we analyzed effects of silver nanoparticles (AgNPs) on microglia in vitro and in vivo. We showed that the AgNPs interact in vitro with stimulated mouse CD45/CD11b positive cells (microglia/macrophages), decrease their secretion of nitric oxide and vascular endothelial growth factor, and regulate the expression of genes for Iba-1 and interleukin-1β (IL-1β). In our in vivo experimental mouse model, the intravitreal application of a mixture of proinflammatory cytokines tumor necrosis factor-α, IL-1β and interferon-γ induced local inflammation and increased local expression of genes for inducible nitric oxide synthase, IL-α, IL-1β and galectin-3 in the retina. This stimulation of local inflammatory reaction was significantly inhibited by intravitreal administration of AgNPs. The application of AgNPs also decreased the presence of CD11b/Galectin-3 positive cells in neuroinflammatory retina, but did not influence viability of cells and expression of gene for rhodopsin in the retinal tissue. These data indicate that AgNPs regulate reactivity of activated microglia in the diseased retina and thus could provide a beneficial effect for the treatment of several retinal diseases.
The marginal value of public funds: a brief guide and application to tax policy
Authors: Bastani Spencer
Published: August 2024

This paper provides a brief and accessible guide to the Marginal Value of Public Funds (MVPF) and offers some new perspectives on its application to the evaluation of tax policy. Specifically, the paper aims to: (i) bridge the gap between traditional uses of the Marginal Cost of Public Funds and the growing interest in the MVPF approach, (ii) highlight the crucial link between the MVPF and tax policy, (iii) critically discuss empirical quantification, particularly with respect to tax elasticities, and (iv) explore distributional considerations and their connection to the literature on optimal redistributive taxation.
Facilitating collaborative inquiry into practice around artifacts of mathematics teaching
Authors: Ebby Caroline B. , Hess Brittany , Pecora Lizzy , Valerio Jennifer
Published: August 2024

Although there has been increasing attention to the importance of teacher agency in professional development, there has been little attention to what it takes to facilitate collaborative work that both centers teachers’ assets and expertise and leads to productive learning. This paper presents a framework for focused and responsive facilitation of productive discourse around instructional practice in teacher learning communities. Drawing on a situative perspective, we trace the development of six novice teacher leaders as they were mentored to lead online collaborative lesson design groups focused on analyzing artifacts of K-8 mathematics instruction in a large urban district in the US. Our framework articulates how leaders facilitated the discussions in ways that both built on teacher knowledge, experiences, and contributions while also focusing on professional learning goals. Our analysis also shows how rich learning opportunities were co-constructed and sustained by the mentors, teacher leaders, and participants in each group over time. Through narrative descriptions of one group, we show how the teacher participants began to take on some of the facilitation practices themselves as they apprenticed into the practices of the community. This approach to professional learning positions teachers’ experience and knowledge as important assets while supporting them to try out and reflect on new classroom practices.
Functional Limit Theorems for Dynamical Systems with Correlated Maximal Sets
Authors: Couto Raquel
Published: August 2024

In order to obtain functional limit theorems for heavy-tailed stationary processes arising from dynamical systems, one needs to understand the clustering patterns of the tail observations of the process. These patterns are well described by means of a structure called the pilling process introduced recently in the context of dynamical systems. So far, the pilling process has been computed only for observable functions maximised at a single repelling fixed point. Here, we study richer clustering behaviours by considering correlated maximal sets, in the sense that the observable is maximised in multiple points belonging to the same orbit, and we work out explicit expressions for the pilling process when the dynamics is piecewise linear and expanding (1-dimensional and 2-dimensional).
Intergenerational Occurrence of Premature Birth and Reproductive Health in Prematurely-Born Women in the Women’s Health Initiative
Authors: Sullivan Mary C. , Brewer Pamela L. , Roberts Mary B. , Wild Robert A. , Shadyab Aladdin H. , Sealy-Jefferson Shawnita , Eaton Charles B.
Published: August 2024

Objective

To compare reproductive history and postmenopausal health by birth status (preterm vs. full term) in a U.S. longitudinal study of postmenopausal women. Birth status was examined according to region of residence, household, and neighborhood socioeconomic status (SES).

Methods

In the Women’s Health Initiative Observational Study, 2271 women were born prematurely (< 37 weeks). ANOVA and Chi-square determined birth status differences of reproductive history, pregnancy, and postmenopausal health. Odds ratios were calculated using either binary logistic or multinomial logistic regression. SES and U.S. region of residence were examined as potential effect modifiers.

Results

Preterm-born women compared to term-born women had higher risk of delivering a premature infant (aOR 1.68, 95% CI [1.46, 1.93]), higher odds of later-age first pregnancy (aOR 1.27 95% CI [1.02, 1.58]), longer duration to become pregnant (> 1 year to pregnancy) (aOR 1.10 95% CI [1.01, 1.21]), more miscarriages (aOR 1.23 95% CI [1.11, 1.37]), and more pregnancy complications including hypertension (aOR 1.58 95% CI (1.13, 2.21)], preeclampsia (aOR 1.64 95% CI [1.24, 2.16]), and gestational diabetes (aOR 1.68 95% CI [1.11, 2.53]). Preterm-born women had higher odds of menopause before age 50 (aOR 1.09 95% CI [1.05, 1.14]). Post-menopause, they had higher rates of diabetes (p = .01), hypertension (p = .01), hysterectomy (p = .045), and higher Charlson Comorbidity Index scores (p = .01).

Conclusions

Preterm-born women had higher reproductive and pregnancy risks which when coupled with early menopause, may indicate a shorter childbearing period than term-born women. Guidelines for integration of preterm history in women’s health care across the life course are needed to identify and manage their higher risk.
Tracking daily paths in home contexts with RSSI fingerprinting based on UWB through deep learning models
Authors: Polo-Rodríguez A. , Valera J. C. , Peral J. , Gil D. , Medina-Quero J.
Published: August 2024

The field of human activity recognition has evolved significantly, driven largely by advancements in Internet of Things (IoT) device technology, particularly in personal devices. This study investigates the use of ultra-wideband (UWB) technology for tracking inhabitant paths in home environments using deep learning models. UWB technology estimates user locations via time-of-flight and time-difference-of-arrival methods, which are significantly affected by the presence of walls and obstacles in real environments, reducing their precision. To address these challenges, we propose a fingerprinting-based approach utilizing received signal strength indicator (RSSI) data collected from inhabitants in two flats (60 m$$ ^2 $$

2

and 100 m$$ ^2 $$

2

) while performing daily activities. We compare the performance of convolutional neural network (CNN), long short-term memory (LSTM), and hybrid CNN+LSTM models, as well as the use of Bluetooth technology. Additionally, we evaluate the impact of the type and duration of the temporal window (future, past, or a combination of both). Our results demonstrate a mean absolute error close to 50 cm, highlighting the superiority of the hybrid model in providing accurate location estimates, thus facilitating its application in daily human activity recognition in residential settings.
Flexibility Stigma Across Europe: How National Contexts can Shift the Extent to which Flexible Workers are Stigmatised
Authors: Chung Heejung , Seo Hyojin
Published: August 2024

Although flexible working has expanded rapidly, especially during the pandemic, biased views against flexible workers – namely, flexibility stigma - are still prevalent and returning. Flexibility stigma hinders worker’s take up of flexible working arrangements and can make flexible working arrangements result in negative outcomes for worker’s well-being and productivity. This study examines how national cultural and policy contexts shape flexibility stigma levels within a country. We use a multilevel approach using the Eurobarometer dataset of 2018, covering 28 European countries, matched with national level aggregate data on policy and culture. Results show that in countries with a more work-life balance work culture and egalitarian gender norms, we see less prevalence of flexibility stigma. Similarly, in countries with generous family-friendly policies, workers are less likely to have negative perception towards flexible working. Finally, stronger bargaining positions of workers, may it be through stronger union power or through better labour market conditions, helps remove stigmatised views around workers who use flexible working arrangements. This study evidences the importance of contexts that shape views around flexible working, to help us better understand policy changes needed to ensure better flexible working practices.
The Development and Initial Validation of the Multidimensional Fairness Scale
Authors: Duff Johnathan H. , Scarpa Michael , Zupluoglu Cengiz , Prilleltensky Isaac
Published: August 2024

Research in psychology, sociology, economics, and other disciplines investigating social justice has identified associations between fair treatment and human well-being. However, the lack of a practical and valid instrument for measuring individual experiences of fair treatment in multiple areas of life has limited the ability to understand the relationship between fairness and wellness. The purpose of these studies was to develop and establish the initial psychometric properties and convergent validity of a scale measuring personal experiences of fairness across various life domains. Development and validation occurred across three studies. Scale development in Study 1 included the generation of items, item revision, and analysis of content validity. A review of existing literature and qualitative data derived from focus group discussions informed the initial pool of items. Cognitive interviews and expert input aided in analysis of content validity and revision of items. Study 2 consisted of confirmatory factor analyses to evaluate the performance of items and determine the underlying factor structure of the scale. In Study 3, factor analyses were used to evaluate convergent validity with other fairness-related instruments. Results of the first study supported the conceptualization of fairness along a social-ecological spectrum: experiences of fairness existed in multiple distinct life domains (e.g., interpersonal, occupational, community). Results from the second study revealed a bifactor model with one general Fairness factor and four Interpersonal, Occupational, Community, and Societal ecological group factors. Results from the third study suggested acceptable convergent validity among some subscales and other established instruments, while also suggesting that refinements to the Community fairness subscale might improve the scale. The final 12-item scale demonstrated good reliability. Results of this study produced an instrument able to measure individual experiences of fair treatment across four life domains.
Alpha-Structures and Ladders in Logical Geometry
Authors: De Klerck Alexander , Demey Lorenz
Published: August 2024

Aristotelian diagrams, such as the square of opposition and other, more complex diagrams, have a long history in philosophical logic. Alpha-structures and ladders are two specific kinds of Aristotelian diagrams, which are often studied together because of their close interactions. The present paper builds upon this research line, by reformulating and investigating alpha-structures and ladders in the contemporary setting of logical geometry, a mathematically sophisticated framework for studying Aristotelian diagrams. In particular, this framework allows us to formulate well-defined functions that construct alpha-structures and ladders out of each other. In order to achieve this, we point out the crucial importance of imposing an ordering on the elements in the diagrams involved, and thus formulate all our results in terms of ordered versions of alpha-structures and ladders. These results shed interesting new light on the prospects of developing a systematic classification of Aristotelian diagrams, which is one of the main ongoing research efforts within logical geometry today.
Finding individualised treatment in obese needing enoxaparin (FIT ONE): a multicentre study of therapeutic enoxaparin and the role of anti-factor Xa monitoring
Authors: Appay Marcelle , Lai Justine , Hay Justine , Calvisi Connie , Wills Geoffrey , Kharadi Shreyas , Nanayakkara Sajani , Ryu Ji Sang , Alameddine Rozanna , Jupp Sarah , Lin Margaretta , Nguyen Jessica , Nguyen Tammy , Harrison Nicholas , Gad Fady , Kagaya Sakura , Nguyen Liam , Piyush Sharma , Shion Vicky , Pandya Advait , Emin Mustafa , Lim Ewe Shen , Rahman Urna , Hayat Farhad , Gajaweera Chamali , Sheriff Nashwa , Patanwala Asad E. , Pasalic Leonardo , Alffenaar Jan-Willem
Published: August 2024

Enoxaparin is dosed according to actual body weight in treatment of arterial and venous thrombosis. Due to its hydrophilic nature, it distributes according to lean body mass which may be problematic when dosing obese patients as this may increase the risk of bleeding events in this population. The aim was to evaluate current therapeutic enoxaparin dosing strategies, including Antifactor Xa (AFXa) level monitoring, in obese patients and to identify factors that contribute to treatment failure and excess anticoagulation. A retrospective cohort study was conducted reviewing patients administered therapeutic enoxaparin between May 2020 and April 2021. Data were collected on patient characteristics, enoxaparin therapy, AFXa monitoring, and outcomes. Regression models were constructed to assess variables of interest to estimate any association with AFXa levels. In total 762 patients were included in the analysis. The mean initial weight-based dose was 0.95 mg/kg twice daily (SD: ± 0.12, IQR 0.92–1.01) and 1.04 mg/kg once daily (SD: ± 0.26, IQR 0.93–1.12) and 14.4% of patients had AFXa monitoring. Treatment failure was experienced by 2.2%, 5% experienced bleeding. There was no association between the mean actual milligram per kilogram weight-based twice daily doses and subtherapeutic, therapeutic and supratherapeutic AFXa levels (P = 0.135). Obesity was not included in the final regression models due to lack of significance. At a mean therapeutic enoxaparin dose of 0.95 mg/kg twice daily and 1.04 mg/kg once daily no excess in treatment failure or bleeding events were observed in obese patients compared to the product information. Obesity was not an independent variable that affected the achievement of target AFXa levels.

Graphical abstract
Self-Narration in the Oppressive Niche
Authors: Fabry Regina E.
Published: August 2024

For several decades, research on situated cognition and affectivity has neglected cases in which environmental features in the niche have a negative impact on agents’ cognitive and affective wellbeing. Recently, however, a new research cluster has emerged that explores how things, technologies, and organisational systems across corporate, healthcare, and educational sectors wrongfully harm certain kinds of agents. This article contributes to this research cluster by integrating work on negative niche construction, structural oppression, enculturation, and self-narration. It thereby offers a new perspective on the negative, structurally oppressive impact of the socio-culturally shaped niche on enculturated self-narration. The main argument is that master plots, understood as narrative arrangements that dominate in the socio-culturally shaped niche, contribute to the structural oppression of enculturated self-narrators with systematically undermined socio-cultural identities. An analysis of the influence of pronatalist master plotting on enculturated self-narration serves to illustrate and strengthen the overall argument.
Small parks in residential neighborhoods as habitats for ground-dwelling beetles, spiders, and ants
Authors: Koji Shinsaku , Furukawa Shun , Ichijo Natsuki , Yamaguchi Yuki , Tanikawa Akio , Kudô Kazuyuki
Published: August 2024

In residential landscapes, small neighborhood parks account for a considerable share of urban greenspaces. However, information on their significance for biodiversity conservation is limited. To determine the role of small neighborhood parks as habitat for ground-dwelling arthropods, we evaluated the effects of local and landscape factors on the diversity and traits of carabid beetles, spiders, and ants in small neighborhood parks in Niigata, Japan. Urbanization decreased carabid species richness and abundance, and it altered the species composition of carabids and spiders. The arthropods in urbanized sites were characterized by small-bodied, web-building, highly dispersive spiders, and possibly non-predatory carabids. In contrast, urbanization did not influence any diversity metrics of ants. At the local scale, ground cover, soil moisture, and park border permeability were the major drivers of arthropod diversity. Ground coverage with leaf litter was positively associated with ant occurrence. Soil moisture negatively affected carabid species richness and abundance, whereas it positively affected spider richness. Parks with humid soil conditions favored hunting, low-dispersive spiders. The low permeability of park borders decreased spider richness and altered community structure, which was characterized by highly dispersive, ballooning species. We conclude that small neighborhood parks support numerous species of habitat-generalist arthropods that are adapted to dry and open environments. These parks thus represent an important component of habitat networks in residential landscapes. Managing open environments, protecting litter layers, reducing artificial borders, and retaining other open greenspaces in the surrounding matrix can promote diverse arthropod communities. Such strategies are worth considering during urban planning.
Photodegradation of the phenylpyrazole insecticide ethiprole in aquatic environments and a comparison with fipronil
Authors: Hirashima Soichiro , Amimoto Tomoko , Iwamoto Yoko , Takeda Kazuhiko
Published: August 2024

Ethiprole (ETH) is a phenylpyrazole insecticide that is used worldwide as an alternative to fipronil (FIP). Research on the photodegradation of ETH in aquatic environments has been limited compared with that on FIP. In this study, to clarify the photodegradation of ETH in aquatic systems, the photodegradation pathway and products were investigated using liquid chromatography and liquid chromatography-tandem mass spectrometry. We also determined the photochemical half-lives (t1/2) of ETH and its main degradation products. The primary photodegradation pathway was cyclization/dechlorination and hydroxylation/dechlorination of ETH to form the didechlorinated products (benzimidazole of des-chloro-hydroxy-ETH). Some newly identified photodegradation products and analogs of FIP photodegradation products were also detected as minor products. We compared the photodegradation of ETH with that of FIP under the same conditions. Didechlorinated products of ETH and FIP had the highest photostability. However, although the photochemical t1/2 of EHT was 2.7 times that of FIP, the photochemical t1/2 of the didechlorinated product of ETH was approximately one-third that of the didechlorinated product of FIP. This comparison of the photochemical processes of ETH and FIP provides new insight into the persistence and characteristics of both insecticides in the environment.
Assessment of dynamics and variability of organic substances in river bank filtration for prioritisation in analytical workflows
Authors: Handl Sebastian , Kutlucinar Kaan Georg , Allabashi Roza , Troyer Christina , Mayr Ernest , Perfler Reinhard , Hann Stephan
Published: August 2024

Bank filtration supports the growing global demand for drinking water amidst concerns over organic micropollutants (OMPs). Efforts to investigate, regulate and manage OMPs have intensified due to their documented impacts on ecosystems and human health. Non-targeted analysis (NTA) is critical for addressing the challenge of numerous OMPs. While identification in NTA typically prioritises compounds based on properties like toxicity, considering substance quantity, occurrence frequency and exposure duration is essential for comprehensive risk management. A prioritisation scheme, drawing from intensive sampling and NTA of bank filtrate, is presented and reveals significant variability in OMP occurrence. Quasi-omnipresent substances, though only 7% of compounds, accounted for 44% of cumulative detections. Moderately common substances, constituting 31% of compounds, accounted for 50% of cumulative detections. Rare compounds, comprising 61%, contributed only 6% to cumulative detections. The application of suspect screening for 31 substances to the dataset yielded results akin to NTA, underscoring NTA’s value. Correlation between both methods demonstrates the efficacy of high-resolution mass spectrometry-based NTA in assessing temporal and quantitative OMP dynamics.
Collaborative Network, Technological Progress and Potato Production in China
Authors: Wang Huaiyu , Wang Qiaoyu , Xiao Yao , Chen Hongshu , Su Zhiwen , Xiang Chao
Published: August 2024

The development of science and technology is one of the vital driving forces for the Chinese agricultural development. Based on 2,513 valid potato invention patents from 1986 to 2019 in China, a social network analysis is applied to investigate the effects of the network changes in potato patents on the innovation activities and potato production. The results show that China has formed a status quo of separation between potato-producing areas and patent-invention places. The collaborative relationships of potato patents are mainly distributed in non-main production areas. Most of the collaborations are intra-provincial rather than inter-provincial. The correlation relationship between potato innovation and potato yield is positive. But the density and cluster coefficients of collaborative networks in potato research affect the potato innovations differently. Considering the variation in collaborative networks and different technology progress in potato production across regions, a cross-regional exchange platform is needed to promote the dissemination and extension of potato patents in the main potato-producing areas.
Community gardens support high levels of food production, but benefit distribution is uneven across the gardener community
Authors: Lin Brenda B. , Bichier Peter , Liere Heidi , Egerer Monika , Philpott Stacy M. , Jha Shalene
Published: August 2024

Urban community gardens are important social–ecological systems from which urban citizens receive many benefits. In this study of 18 urban community gardens in the Central Coast of California, USA, we use a combination of gardener surveys and field-based measurements to evaluate the amount of fresh fruit and vegetables produced by gardeners. We then investigate how food production differed between segments of the gardening population, specifically as a function of gardening experience, time spent in gardens, and food security status. Lastly, we ask gardeners to describe their motivations for gardening to better understand how motivations may relate to individual levels of food production. Thirty-eight percent of gardeners estimate harvesting one to five pounds of food per week, with another 26% estimating six to ten pounds. These estimates were corroborated by field measurements of tomato, squash, and pepper cultivation, where gardeners produced, at the height of the harvest season, an average of four pounds of food per week—an estimated savings of ~ $16USD per week (compared to the cost of local organic fruits and vegetables, June 2023 prices). Regarding the ability of community gardens to reduce food insecurity, gardeners who spent more time in the garden and with higher incomes reported higher food security, while those with larger families or lower incomes were more food insecure. These results show that gardeners in most need of food support were not necessarily the ones cultivating the most fruits and vegetables. While 48% of gardeners reported food cultivation as a primary motivator for gardening, many other motivations (e.g., hobby, being outdoors, relaxation, social interaction, and exercise) were identified as reasons to spend time in the garden, indicating that food production is not the only factor motivating gardeners. Overall, we document that community gardens can be highly productive and provide valuable produce that substantially offsets high fresh food costs; however, gardeners with the greatest food needs are currently not the largest producers, but could benefit from additional resources and support.
Micro-cold Spray Deposition of YSZ Films from Ultrafine Powders Using a Pressure Relief Channel Nozzle
Authors: Bierschenk Stephen G. , Kovar Desiderio
Published: August 2024

The use of ultrafine powders in the micro-cold spray (MCS) process, also referred to as the aerosol deposition method, typically results in porous and/or poorly adhering films because the particles do not impact at a high enough velocity for sufficient plastic deformation and interparticle bonding to occur. Under typical operating conditions, particles < 100 nm accelerate to high velocities but then are slowed by the stagnant gas in the bow shock that forms just upstream of the substrate. Using larger particles reduces particle slowing, but large particles can cause erosion of the film at high impact velocity, decreasing deposition efficiency. In this study, a pressure relief channel nozzle using helium as a carrier gas is proposed such that high-velocity deposition of yttria-stabilized zirconia particles as small as 10 nm in diameter is possible. This is well below the size range of powders previously used for MCS. The proposed nozzle design increases impact velocities for 10, 20, and 50 nm particles by ~ 880, 560, and 160 m/s, respectively, when compared to a conventional nozzle. Experimental deposition of ultrafine 8YSZ powder shows that the pressure relief channel nozzle results in lower porosity and more uniform deposits, with a ∼ 186% increase in deposition efficiency.
Changes in MRI head motion across development: typical development and ADHD
Authors: Thomson Phoebe , Loosley Vanessa , Friedel Emily , Silk Timothy J.
Published: August 2024

Head motion is a major confounding variable for magnetic resonance imaging (MRI) analysis, and is commonly seen in individuals with neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). This study investigated the trajectory of change in head motion in typically developing children and children with ADHD, and examined possible altered trajectories in head motion between children with remitted and persistent ADHD. 105 children with ADHD and 84 controls completed diffusion and resting-state functional MRI scans at up to three waves over ages 9–14 years. In-scanner head motion was calculated using framewise displacement, and longitudinal trajectories analyzed using generalized additive mixed modelling. Results revealed a significant age effect on framewise displacement where head motion decreased as age increased during both diffusion (p < .001) and resting-state functional MRI (p < .001). A significant effect of group was also observed; children with ADHD displayed greater framewise displacement than controls over the age range (diffusion MRI p = .036, functional MRI p = .004). Further analyses revealed continued elevation in head motion in children in remission from ADHD (diffusion MRI p = .020, functional MRI p = .011) compared to controls. Rates of change in head motion did not significantly differ between diagnostic groups. Findings indicate a critical link between in-scanner head motion and developmental age within children regardless of ADHD diagnosis, important to consider in studies of neurodevelopment. Findings also suggest change in head motion with age does not differ between individuals with remitted and persistent ADHD, adding further evidence that behavioral manifestations of ADHD may continue despite clinical remission.