bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systems Engineering Approach to A Technology Planning System For Companies Seeking To Operate In Configure-To-Order Markets
Authors: Moore J Anthony , Adams Jim , Sega Ronald
Published: December 2024

Technology Planning is critical for businesses in the Configure-To-Order market that want to establish themselves, gain traction, and thrive in the marketplace. Planning on a generational horizon ensures market satisfaction. The technology planning process must translate the brand strategy into the technology development process. This work explores a previously unrecognized system that ties business strategy to technology development efforts, revealing a missing interface between them. Using a Systems Engineering Framework, a repeatable process from brand strategy through feature development and product deployment is proposed for Configure-to-Order Markets, better meeting customer needs and increasing the technology's value.
BAHASA INDONESIA SEBAGAI STANDARISASI BAHASA NASIONAL : KAJIAN SOSIOLINGUISTIK
Authors: Zihan Ahmad Khawarizmi
Published: December 2024

Standarisasi bahasa merupakan prosesyang penting dalam menjaga konsistensi dan efektivitas komunikasi di antara individu-individu yang menggunakan bahasa yang sama. Penelitian ini bertujuan untuk mengeksplorasi dampakstandarisasi bahasa dalam berbagai aspek kehidupanmasyarakat. Metode penelitian yang digunakan meliputianalisis teks dan studi kasus. Analisis teks digunakan untukmemahami bagaimana standarisasi bahasa memengaruhi gayapenulisan dan komunikasi tertulis. Studi kasus dilakukanuntuk menginvestigasi dampak standarisasi bahasa dalamkonteks yang lebih terperinci, termasuk pendidikan, budaya, dan ekonomi. Hasil penelitian menunjukkan bahwastandarisasi bahasa memiliki dampak positif dalammeningkatkan efisiensi komunikasi, memfasilitasi pendidikan, memperkuat identitas budaya,dan memungkinkan partisipasidalam ekonomi global. Namun, terdapat juga dampak negatifseperti pengurangan keragaman linguistik dan potensi konflikbudaya. Penelitian ini menyajikan pemahaman yang komprehensif tentang pentingnya standarisasi bahasa dalammendukung komunikasi efektif dan memfasilitasipembangunan masyarakat yang inklusif dan berkelanjutan.
RAGAM BAHASA LISAN PENJUAL DAN PEMBELI DI PASAR RUBARU, KECAMATAN RUBARU, KABUPATEN SUMENEP KAJIAN SOSIOLINGUISTIK
Authors: Mahbub Moh. Tarojjil
Published: December 2024

This study aims to examine oral conversations between sellers and buyers in Rubaru market, known for its linguistic diversity. The main focus is to describe the language variations used by both parties as well as the influencing factors. By employing a sociolinguistic approach and qualitative descriptive method, this research aims to present an overview of the social phenomena emerging from the conversation data. The data collection process involves direct observation at the market, recording conversations, and detailed note-taking. Through observing buying and selling transactions, conversations are recorded, transcribed, and then data is classified and grouped. The research focuses on the use of Madura language by both parties in transactions. The research findings encompass a variety of conversations between sellers and buyers in Rubaru market, showing oral language variations based on sociolect, including acrolect and basilect. Factors such as age, time, location, and gender are also found to influence the language variations used by sellers and buyers in these conversations.
Ciudadanía, comunidad y conflicto
Authors: Vázquez Martínez Alejandro Ernesto , Ramírez Gómez Ana Elizabeth
Published: December 2024

Como sucede con todas las categorías o conceptos dirigidos al análisis, interpretación y explicación de la realidad social, las categorías de ciudadanía, comunidad y alteridad, actualmente no sólo definen — en cierta medida— dinámicas y procesos socioculturales, geopolíticos y económicos, pues del mismo modo representan la posible correspondencia e integración de las prácticas de diversos grupos con los marcos teóricos que buscan su pertinencia y viabilidad;...
¿Qué es la Gerontología y que hace en la Universidad Autónoma de Ciudad Juárez?
Authors: Castellanos Vargas Rosa Olimpia
Published: December 2024

El logro más importante de la humanidad en el siglo XX ha sido el incremento en la esperanza de vida. Actualmente se vive más tiempo en todo el mundo. Según la Organización Mundial de la Salud, por primera vez en la historia, la mayor parte de la población tiene esperanza de vida igual o superior a los 60 años (OMS, 2015).

Atendiendo a este incremento de la población mayor, a sus necesidades y las recomendaciones internacionales y regionales, la Universidad Autónoma de Ciudad Juárez (UACJ), se une a esta labor, abriendo el programa de Licenciatura en Gerontología en la División Multidisiplinaria de Ciudad Universitaria.
COMPARATIVE PERFORMANCE ANALYSIS BETWEEN MYSQL AND MONGODB DATA STORAGE ENGINES TO SUPPORT DYNAMIC CONTENT OBJECTS
Authors: Calderón Moreno Roger , Rubiano Bacca Edwin David , Parra Linares Luis Alberto
Published: December 2024

Comparative performance analyses enable users to take informed decisions on technologies beyond current market trends and/or commercial information from vendors. In this paper we present a comparative performance analysis between MySQL and MongoDB, based on data from the Dynamic Survey Manager at the Planes de Energización Rural Sostenible, Región Orinoquía project. First, we proposed a document-based data storage model to support the current relational model. This model allows a flexible structure and storage of information for the organization in future. Then, we configured the document-based model on MongoDB. Subsequently, we measured and compared performance times by using selected test scenarios. Finally, we found MongoDB has at least 40% better response times, in addition to the flexibility in the information structure and storage with respect to MySQL. MongoDB’s flexibility allows software developers to skip the object relational mapping within their data persistence layer, while supporting ACID-type transactions (Atomicity, Consistency, Isolation, Durability). Despite the positive results, we found a test scenario where MySQL outperformed MongoDB. For queries involving larger objects (e.g., > 100MB), MongoDB was 7.5% slower than its counterpart.
Transcendental Abundance: A Theo-cosmological Foundation of Islamic Economics
Authors: Sandimula Nur Shadiq
Published: December 2024

The modern Western civilization infused with the dominance of humanism and secularism has pushed religion away from being involved in scientific developments. The invested paradigm also devoted and flourished in conventional economics disciplines, and unfortunately, the concept is also attached to Islamic economics. One of the doctrines constructed is the cosmological doctrine, which declares that resources are limited and initiates the most fundamental economic problem, scarcity. This study aims to scrutinize the cosmological presupposition in economics by utilizing the Islamic worldview conceptualized by al-Attas. The method is a descriptive-philosophical examination with a thematic analysis approach. This research reveals that God plays an active role in all myriad layers of creation which necessitates His transcendental association with the cosmos. God has names and attributes that introduce his transcendent and immanent presence in the universe. Terms in the Qur'an such as rizq, ni'mah, minnah, ala', and al-fadhl semantically indicate God's transcendental abundant sustenance in the world. The theo-cosmological concept of the Islamic worldview revealed the reality of Islamic economics perceives that resources have an unlimited source of its transcendence.
Mapping Islamic Social Finance’s Impact on SDGs: A Bibliometric Dive into Decent Work and Economic Growth
Authors: Nisak Khoirun
Published: December 2024

Introduction: The SDGs are goals that countries around the world want to achieve by 2030. However, this bis project requires a lot of funding. So it requires other alternative funding such as Islamic social finance. This research wants to examine the funding of SDGs, especially goal number 8 using Islamic social finance instruments. Research Methods: This study adopts a bibliometric approach by analyzing 500 articles published between 2015 until 2024 using Publish or Perish, which were sourced from Google Scholar. Based on their focus on Islamic social finance and the SDGs number 8, 25 relevant articles were selected from this initial pool. Keyword analysis, network visualization, and density mapping were performed using VOSviewer software. Examining keyword occurrences and temporal overlaps helped to identify dominant themes, gaps, and emerging areas of focus in Islamic social finance research. Result: The results show that zakaf and waqf are the most frequently discussed topics. This underscore their central role in aligning Islamic financial principles with SDGs. However, instruments such as sadaqah, qard al-hasan, and takaful continue to be under-explored, pointing to significant gaps in the literature. Conclusions: As a recommendation, to fully understand their potential contributions to the SDGs  number 8, further research on other Islamic social finance instruments beyond zakat and waqf is needed.
Vegetation growth conditions strongly indicate coffee flowering anomalies
Authors: Nguyen Thi Thu Thuy , Kath Jarrod , Reymondin Louis , Nguyen-Huy Thong , Byrareddy Vivekkananda Mattahalli , Mushtaq Shahbaz
Published: December 2024

Quantifying the timing of vegetation growth, particularly coffee plant flowering, is vital for estimating yield in advance. While satellite-based vegetation indices are effective in mapping crop growth and have a strong correlation with coffee yield, the potential contribution of plant conditions alongside climate factors in predicting coffee flowering anomalies remains underexplored. Here, our investigation aimed to determine whether satellite-based vegetation indices, in addition to climate variables, could enhance the model's predictive power for flowering anomalies of coffee trees. Utilizing a dataset on flowering dates over ten years of 558 coffee farms spread over four provinces (Dak Lak, Gia Lai, Dak Nong, and Lam Dong) in the Central Highlands of Vietnam, we analysed climate variables (rainfall and temperature) and the Normalized Difference Vegetation Index (NDVI) at various intervals prior to flowering dates. Using a Generalized Additive Model (GAM) and model selection based on Akaike’s Information Criteria (AIC), we identified the most influential predictors. Then, we performed Structural Equation Modelling (SEM) to further investigate the complex causal relationships among flowering anomalies, climate, vegetation, and management factors. Our results show that the NDVI prior to flowering dates held the most explanatory power, outperforming climate variables. Lower NDVI during the dormancy period indicated the ripe-to-flower condition of the coffee tree, informing earlier onset of the flowering stage, while higher NDVI during bud initiation and development stage suggested a delayed flowering. The best model incorporating both climate and NDVI predictors achieved good explanatory performance with an adjusted R2 of 0.87. The analysis highlighted the advantages of vegetation indices over climate predictors in capturing plant conditions through its growing cycle, with the accumulated effects of environmental factors and agricultural management activities, especially during critical phenological stages. Our findings suggest further studies utilising vegetation indices from remote sensing data sources at multiple scales to thoroughly understand plant conditions at different crop growth phases, especially at early stages, for site-specific, timely and strategic management interventions.
How do ballast water, pitch angle, and tower material impact the optimization of a concrete semisubmersible floating offshore wind turbine?
Authors: Chujutalli John H. , Almeida Jeferson Osmar , Amiri Mojtaba Maali , Lima Paulo Roberto Lopes , Shadman Milad , Junkai Feng , Filho Romildo Dias Toledo , Levi Carlos , Estefen Segen F.
Published: December 2024

Despite significant progress in floating offshore wind turbine (FOWT) technology , there are still several challenges, including the design of a cost-effective system. Considerable research has been dedicated to optimizing the floating platform geometry, layout, dimensions, and weight over the past few years, with some focusing on semisubmersible platforms, where steel is often used for both the platform and tower. However, concrete FOWTs may be more cost-effective and reduce the carbon footprint. Other areas requiring further research include the impact of the tower material, maximum inclination angle, and confining ballast water within dimensionally variable compartments during optimization. The study aims to address these points through a hydrostatic optimization of a novel 15 MW concrete semisubmersible FOWT using a genetic algorithm method. The results show that the platform mass reduction for pitch angles larger than 6 degrees is lower compared to that for angles smaller than 6 degrees regardless of the tower material. Moreover, confining the ballast water inside dimensionally variable compartments leads to a lower semisubmersible platform weight. Finally, an initial comparison of raw material costs shows that a concrete platform with a steel tower offers the most cost-effective solution compared to a FOWT entirely made from steel or concrete.
Does environmental decentralisation affect industry green economy efficiency?The Moderating Effect of the Institutional Environment
Authors: Chen Haisheng
Published: December 2024

Based on the SBM-GML model, the green total factor productivity (TFP) of agriculture, industry and service industry is measured based on the provincial panel data of China from 2003 to 2022, and the scientific spatial econometric method is used to comprehensively assess the impact and moderating effect of the environmental decentralisation on the green TFP of the industries in China. The study confirms that the relationship between environmental decentralisation and industry green total factor productivity is generally inverted "U" shape. It is further found that the effect of environmental decentralisation on industry green TFP is consistent with the overall effect in the central region, while in the eastern region the relationship is "U" shaped, and in the western region it is not obvious. The institutional environment is an important moderator of the impact of environmental decentralisation on industry green TFP, which is reflected in the government-market relationship, the development of non-state economy, the development of market intermediary organisations and the legal environment. This paper provides ideas for a deeper understanding of "environmental decentralisation" and its impact on the industry.
Is there an association between a behavioral measure of working memory and the measures of P300
Authors: Shubhadarshan Archisman , Mishra Sushmit
Published: December 2024

Background: In recent times, the P300 has been extensively explored to assess cognitive function and contextual knowledge in humans. The main aim of the study is to explore whether the scores obtained in behavioural tests for Working Memory (WM) like the Reading Span Test (RST) is associated with electrophysiological tests like P300. A total of 60 participants in the age range of 18-40 were included in this study, of which 30 participants were included in group 1 who had normal hearing sensitivity, and the other 30 were included in group 2 who had bilateral hearing loss (HI). Participants had normal cognitive functioning and were screened for having normal cognitive abilities using a test. After completing basic hearing assessment tests, RST and P300 were administered.
Result: We found a strong positive correlation of P300 amplitude with RST in normal hearing and HI groups. A moderate negative correlation was found between P300 latency and RST in the normal hearing group while a weak correlation was found in the HI group for the same. In both the groups Reaction Time has a strong correlation with amplitude and latency of P300.
Conclusion: We may use P300 amplitude to estimate the WM capacity and the latency of P300 may be also essential to evaluate the lexical access capacity of working memory.
Heterogeneity and risk prediction study of self-reported outcomes in patients with abdominal wall stoma for bladder cancer based on latent profile analysis and machine learning algorithms
Authors: Ren Jia-Hui , Lu Jing-Ya , Xiong Zhu-Feng , Zhang Yong-Hui , Hong Hui , Yang Mei-Yun
Published: December 2024

Abdominal wall stomas in bladder cancer patients can severely impact physical, psychological, and social adjustment. However, individual differences in patients' self-reported outcomes and their influencing factors require further investigation. This multicenter, cross-sectional study aimed to assess the health status of patients with bladder cancer and abdominal wall stomas, identify heterogeneous characteristics among individuals, and screen for risk factors affecting their quality of life. We evaluated 598 patients who underwent radical cystectomy with an abdominal wall stoma between September 2020 and September 2023 in the urology departments of five tertiary hospitals across Henan and Jiangxi Provinces, China. Data were collected via a self-designed general profile questionnaire and the Chinese Patient Self-Reported Outcome Scale for Bladder Cancer with Abdominal Wall Stoma (PROS-BCAS). Latent profile analysis identified three patient subgroups: "balanced high quality" (n = 339, 56.7%), "unbalanced" (n = 148, 24.7%), and "low level" (n = 111, 18.6%). Significant differences were observed in the scores of the four PROS-BCAS domains among these categories (p < 0.05). The factors associated with the "low-level" group included age (45–60 years), low income (monthly per capita <$2,000), self-payment for healthcare, total lack of self-care ability, and the presence of comorbidities. The XGBoost machine learning model identified key factors affecting patient prognosis, such as monthly per capita income, age, healthcare payment method, stoma care status, and comorbidities, in descending order of importance. These findings emphasize the significant individual heterogeneity in self-reported outcomes among bladder cancer patients with abdominal wall stomas. Clinical caregivers should therefore assess and tailor interventions to improve quality of life, particularly for the vulnerable subgroups identified in this study.
A Comprehensive Evaluation and Assessment of Surface Water Quality Using Multivariate Techniques
Authors: Kushwah Vinod Kumar , Singh Kunwar Raghvendra
Published: December 2024

Surface water pollution is now a major environmental concern on a worldwide scale. To maintain water quality at a specific desired level and to understand the current state of the water resource, surface water monitoring and assessment are crucial. This investigation relies on multivariate statistical techniques including cluster analysis, discriminant analysis, principal component analysis to assess the variations of surface water quality in the Mathura region. Water samples were collected from eleven different natural kunds, Mathura district. CA employed all water quality parameters to generate three clusters according to the similarity of their respective characteristics. A total of five components, explained 86.72 percent of the observed variance. PCA's utility for assessing and interpreting sizable, complex water quality data sets, and allocating water pollution sources/factors, Surface runoff, storm runoff, soil weathering, leaching, domestic discharge and agricultural runoff were identified as significant contributors to the deterioration of surface water quality. By employing Discriminant Analysis, five water quality parameters (TH, TDS, Na+, DO, and BOD5) were successfully identified during the spatial evaluation of natural kunds, with 100% assignment rate. Therefore, this study emphasizes relevance and efficacy of MSTs for accomplishing sustainable water resource management while recognizing the sources of water quality variations.
A Constraint Disaggregation Method for Structure-Preserving Aggregations in LP Problems: Application to Renewable Energy Grids with Hydrogen Storage
Authors: Riccardi Gabor , Urso Bianca , Gualandi Stefano
Published: December 2024

In recent years, the integration of renewable energy sources into electrical grids has become a critical area of research due to the increasing need for sustainable and resilient energy systems. To address the variability of wind and solar power output over time, electricity grids expansion plans need to account for multiple scenarios over large time horizons. This significantly increases the size of the resulting Linear Programming (LP) problem, making it computationally challenging for large scale grids. To tackle this, we propose an approach that aggregates time-steps to reduce the problem size, followed by an iterative refinement of the aggregation, in order to converge to the optimal solution. Using the previous iteration's solution as a warm start, we introduce and compare methods to select which time intervals to refine at each iteration. The first method selects time-steps based on the proportion of net power production within each interval. We provide a general theoretical justification for its use and sufficient conditions under which an optimal solution of an aggregated linear problem can extend to an optimal solution of the original problem. The second method employs a Rolling Horizon (RH) method to evaluate the feasibility of the aggregated solutions, and selects the time interval on which the validation fails. These selection methods are then compared against a random interval selection approach.
Mathematics Subject Classification (2020) 90-10 · 90B15
Quantitative trait loci underlying the yield-related traits in perennial Chinese rice "Shengdao3 # "
Authors: Yan Yuxin , Peng Tingshen , Lu Jiuyan , Tan Lin , Nan Wenbing , Qin Xiaojian , Li Ming , Gong Junyi , Liang Yongshu
Published: December 2024

"Shengdao3#" is a novel type of perennial rice germplasm native to China. And so, this study aimed to explore the genetic information about the yield traits in perennial Chinese rice "Shengdao3#" and provide a series of theoretical bases for the innovative utilization of perennial Chinese rice germplasm. The F2 population derived from the cross between "Shengdao3#" and common rice "XiqingzaoB" was developed to identify QTLs underlying yield-related traits. Fifteen yield traits including plant height, panicle plant− 1, and thousand-grain weight were measured for the QTL mapping. The software packages Excel 2010, GraphpadPrism 5.0, and QTLIciMapping 4.20 were used to perform the phenotypic data analysis and QTL mapping, respectively. Results indicated 15 yield-related traits displaying normal distribution and belonging to quantitative trait inheritance. Altogether 25 QTLs underlying the yield-related traits and 26 epistatic QTLs were detected on the whole genome except for the 6th and 12th chromosomes, and explained phenotypic variance with ranging from 4.21–27.30% and 1.15–19.30%. Six pleiotropic QTL underlying two or more yield-related traits were detected on the 1st, 4th, 7th, 8th, and 11th chromosomes. Among 25 QTLs underlying a single yield-related trait, 11 were primarily identified in the perennial Chinese rice "Shengdao3#". All QTLs underlying 15 yield-related traits followed the genetic model of additive, dominant, and digenic epistatic of additive by additive, additive by dominant, dominant by additive, and dominant by dominant. This work can serve as a good foundation for yield-related gene mining from "Shengdao3#" and its utilization in the future sustainable agriculture.
Non-coding genetic variants underlying higher prostate cancer risk in men of African ancestry
Authors: Hannenhalli Sridhar , Li Shan , Fatema Kaniz , Nidharshan Sundarraj , Singh Arashdeep , Rajagopal Padma Sheila , Notani Dimple , Takeda David
Published: December 2024

Incidence and severity of prostate cancer (PrCa) substantially varies across ancestries. American men of African ancestry (AA) are more likely to be diagnosed with and die from PrCa than the those of European ancestry (EA). Published polygenic risk scores for developing prostate cancer, even those based on multi-ancestry genome-wide association studies, do not address population-specific genetic mechanisms underlying PrCa risk in men of African ancestry. Specifically, the role of non-coding regulatory polymorphisms in driving inter-ancestry variation in PrCa has not been sufficiently explored. Here, by employing a sequence-based deep learning model of prostate regulatory enhancers, we identified ~ 2,000 SNPs with higher alternate allele frequency in AA men that potentially affect enhancer function associated with PrCa susceptibility, as supported by our experimental validation. The identified enhancer SNPs (eSNPs) may influence PrCa development through two complementary mechanisms: 1) the alternate allele that increase enhancer activity result in immune suppression and telomere elongation, and 2) the alternate alleles that decrease enhancer activity, lead to de-differentiation and inhibition of apoptosis. Notably, the eSNPs tend to disrupt the binding of known prostate transcription factors including FOX, AR and HOX families. Lastly, the identified eSNPs can be combined into a polygenic risk score that adds value to current GWAS-based risk variants in assessing PrCa risk in independent cohorts.
Blocking or Embracing the Competition: Discussing the Trade War on the Electric Vehicle Industry from a Global Perspective
Authors: Kouam Arthur William Fodouop
Published: December 2024

This study examines the multifaceted impact of the ongoing US-China trade war on the global electric vehicle (EV) industry, scrutinizing how tariffs, supply chain disruptions, and competitive dynamics have reshaped production costs, market share, and innovation strategies. Utilizing a mixed-methods approach, we conducted quantitative analyses through Multiple Linear Regression (MLR) on data collected from 20 leading EV markets. We complemented these findings with qualitative insights from semi-structured interviews with 15 industry experts. Our analysis reveals that the imposition of tariffs significantly elevates production costs for EV manufacturers, leading to a notable shift in market share from Chinese firms to domestic producers in tariff- imposing countries. Furthermore, the findings illustrate that companies embracing collaborative competition tend to foster higher levels of innovation compared to those adopting protectionist measures. By integrating International Trade Theory and Dynamic Capabilities Theory, this research adds to the existing literature on trade wars and industrial competitiveness, highlighting that while tariffs may offer temporary protections, they hinder long-term innovation and resilience in the EV sector. This study fills a critical gap by providing a comprehensive analysis of the trade war's implications on a global scale, offering strategic recommendations for policymakers and industry stakeholders navigating a rapidly evolving landscape.
Jelcodes: F13, L62, O38
Protein Kinase A is a Dependent Factor and Therapeutic Target in Fibrous Dysplasia
Authors: Zhao Xuefeng , Liu Zhongyu , Xing Lu , Huang Wenlong , Ji Ning , ZHAO Hang , Chen Qianming , Han Xianglong , Bai Ding
Published: December 2024

Fibrous dysplasia (FD) is a skeletal disorder caused by activating mutations in Gαs, leading to bone fractures, deformities, and pain. Protein kinase A (PKA), the principal effector of Gαs/cAMP signaling, plays critical roles in various biological processes. However, its role in FD is unknown. Here, we demonstrate that PKA activation replicates FD-like lesions in a transgenic mouse model expressing an activating mutation of the PKA catalytic subunit α (PKAcαW197R) in the skeletal stem cell (SSC) lineage. Mechanistically, PKA promotes osteoclastogenesis and aberrant osteogenic differentiation and proliferation of SSCs, while impairing mineralization. Interestingly, downregulating PKA activity, using either a genetically engineered PKA inhibitor peptide or small-molecule inhibitors, effectively alleviates FD lesions in an FD mouse model and safeguards bone health by increasing trabecular bone volume in an osteoporosis mouse model. These findings demonstrate that PKA is a dependent factor in FD initiation and progression, underscoring its potential as a therapeutic target.
The association of phenotypic age acceleration with erectile dysfunction among adult males in the United States: A cross-sectional study based on NHANES 2001-2004 database
Authors: Zhou Yiwen , Cai Yuxi , Zheng Pengfei , Chen Xinglin , Mu Zezhong , Xu chenyang , Mao Shanhua
Published: December 2024

Objective The purpose of this study is to examine the relationship between phenotypic age acceleration (PhenoAgeAccel) and erectile dysfunction (ED) in US males, utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 2001 and 2004.Methods This study explored the relationship between PhenoAgeAccel and ED by analyzing a sample reflecting the male population of the United States (n = 1,977; NHANES 2001–2004). Phenotypic age (PA) is calculated using nine blood-based biomarkers. PhenoAgeAccel was calculated by extracting the residuals and regressing the phenotypic age on the chronological age (CA). The evaluation of ED was based on a single-item measure of self-reported erection problems derived from the Massachusetts Male Aging Study. This research used multivariable logistic models to examine the connection between PhenoAgeAccel and ED. Additionally, it included subgroup and interaction analyses to assess variations among different groups. Smoothed curve fitting and generalized additive modelling (GAM) were also employed to analyze the data further.Results The study cohort comprised 1,977 subjects, of whom 559 were diagnosed with ED and 1,418 were not. The weighted multivariate logistic regression model indicated that there was a 3% higher probability of ED for each unit increase in PhenoAgeAccel (OR: 1.03, 95% CI: 1.01–1.06) after accounting for all covariates. The results of the subgroup analysis were consistent across all categories, indicating a significant positive correlation between PhenoAgeAccel and ED. The results of the interaction tests demonstrated that the positive correlation between PhenoAgeAccel and ED remained consistent, with all interaction p-values exceeding 0.05. Additionally, a non-linear relationship was identified between PhenoAgeAccel and ED, whereby an elevated PhenoAgeAccel was associated with a progressive increase in the risk of ED, exhibiting a J-shaped curve (inflection point: -0.86, p < 0.05).Conclusions The findings of our study indicate that an increase in PhenoAgeAccel may be associated with an elevated risk of developing ED. Consequently, PhenoAgeAccel represents a promising biomarker for the early identification of individuals at risk for ED, with significant implications for the management of men's health and the implementation of public health nutrition strategies.
Willingness-to-pay and costs for novel manual emptying services for onsite sanitation facilities in an informal settlement of Nairobi, Kenya
Authors: Tomoi Hiroaki , Ingumba Bonface Butichi , Simiyu Sheillah , Ross Ian , Braun Laura , Moriyasu Taeko , Cumming Oliver
Published: December 2024

Nearly half of the global population currently use onsite sanitation systems such as pit latrines. Access to safely managed sanitation is essential for public health but emptying services for onsite sanitation are often unsafe for both users and service providers. The study aims to assess willingness-to-pay (WTP) for two safer manual emptying services. The first is referred to as the “Standard Plan”, a hypothetical safer manual emptying service, and the second is referred to as the “Small-amount Plan”, a hypothetical service with a volumetric limit. The costs of the two services were also estimated to assess their financial feasibility. We surveyed 400 households in an informal settlement in Nairobi, Kenya by a contingent valuation method. The mean WTP for the “Small-amount Plan” was $1.4/drum, which was $0.2/drum lower than the WTP for the “Standard Plan”. Whilst the WTP was lower, the estimated cost of the Small-amount Plan where emptiers can visit multiple toilets was $0.9/drum lower than the cost for the “Standard Plan” where emptiers visit one toilet. Our results suggest that grouping multiple toilets could be a market viable cost-reduction strategy for safe manual emptying and warrant further research to develop and test this approach which may increase access to safely managed sanitation in low-income informal urban areas. (209 words)
Assessing the Impact of Digital Literacy Competency on Academic Outcomes: A Theoretical Model Validation Study
Authors: Muammar Suadad , Maheshwari Piyush , Atalla Shadi
Published: December 2024

As technology becomes integral to education, especially with the emergence of advanced artificial intelligence applications, students require advanced digital literacy (DL) skills to succeed both academically and professionally. DL, defined as the ability to use digital technologies with a positive attitude toward digital learning, is explored in this study. The literature review for this study identified gaps in understanding the relationship between DL and academic performance. Current studies lack comprehensive data across university levels and majors, have limited representation of diverse student populations, and do not offer a unified understanding of the collective impact of DL skills on performance. This study aims to explore digital competence among higher education students using a tailored theoretical model, focusing on the impact of these competencies on academic performance. Employing a customized DL theoretical model that incorporates 22 competencies across three domains—computer and information skills, advanced production, and digital security—this research also considers demographic influences, such as sex and year of study. This study used partial least squares structural equation modeling and other statistical methods to investigate the relationships among these 22 competencies and their impact on students’ academic performance. The findings revealed a significant correlation between computer and information skills and student performance with variations according to demographic factors. This study enhances academic understanding of DL and offers practical insights into educational strategies and policy development in higher education. This streamlined approach to developing a DL framework addresses the changing educational needs of undergraduate students.
Student scientific societies as a form of youth organisation
Authors:   St. Petersburg State University, Koshkin Andrey V.
Published: December 2024

This article examines student scientific societies (SSS) of higher educational institutions in
Russia. The research hypothesis is that there are two basic types of SSS, which conditionally
can be described as SSS “for oneself ” and SSS “for others”. The student scientific society, which
conditionally exists for oneself, proceeds on the assumption that science is not very interesting
to all students. In that tradition of goal-setting SSS is perceived as a community of interest
without claiming any representativeness. Respectively, existing “for others” SSS proceeds from
the need to popularise scientific knowledge and the academic track of personal growth among
young people. Such SSS is aimed rather at holding as many events as possible with the largest
possible number of people. In the course of exploring student scientific societies the expert
survey of the heads of 81 SSS from 59 higher education institutions and 29 regions of Russia
was conducted. As the main research methods of the survey results were selected correlation
and cluster analysis. The hypothesis has been partially confirmed. SSS really can be divided
into types “for oneself ” and “for others”, but within the SSS “for others” type there may be
the existence of distinct subtypes that characterize differences in their activities. It was also
revealed that the SSS “for others” type is more popular among student scientific societies of
higher educational institutions in Russia. Weak correlations were found between number of
SSS events, number of participants in SSS events and budgetary and extrabudgetary funding
of SSS. A stable correlation was found between the number of participants in SSS, involved in
Russian Science Foundation grants and budgetary and extrabudgetary funding of SSS. However,
correlation between the SSS region and funding goes missing. At the same time, the conformity
assessment of student scientific societies has been carried out with the images of SSS
“for oneself ” and “for others”. Here are the top 5 SSS, which are most relevant to the images of
SSS “for oneself ” and “for others”.
Social institutions and economic development: А case study of the relationship between Latin America, Africa and Asia
Authors:   St. Petersburg State University, Voronin Vsevolod A.
Published: December 2024

The article deals with the problem of the impact of public institutions on the economic development
of Latin America, Africa and Asia. The degree of interrelation of these two factors was
determined by constructing correlation graphs and calculating the correlation value between
the index of economic freedom (ECO) and GDP per capita at purchasing power parity. The
relevance of the selected indicators is justified. First, all the sample countries are included in
the calculation, then, to consider the relationship of these indicators in dynamics, the countries
that are most seriously out of correlation. The main provisions of the historical trend of neoinstitutional
theory are analyzed, in the context of which specific regional cases are considered.
For a more detailed consideration of correlation discrepancies, China, India and Indonesia were
used in the Asian case; Egypt, Algeria, Nigeria, Ethiopia, Tanzania in the African case; Argentina,
Peru, Colombia and Mexico in the Latin American case. This part of the study showed that
with a lower level of economic freedom, the state’s economy can show higher rates of economic
growth compared to its neighbors. The empirical part of the study ends with the construction
of a graph reflecting the dynamics of the ratio of EPS and GDP per capita by PPP in the last
13 years. Quantitative research has shown that economic freedom is not the main dominant
factor of the level of economic development and the rate of production growth. The discussion
part includes a presentation of alternative directions in political economy, which highlight other
factors and dominants of production growth and economic development in general.
Santa Marta borrada del mapa 1655
Authors: Andrés Alán
Published: December 2024

"Santa Marta borrada del mapa 1655" es el cómic ganador del tercer puesto de la Convocatoria para artistas del Comic "Sumérgete en el océano del cómic" realizada en el marco de la quinta edición de la Feria Internacional del libro, las artes y la cultura de Santa Marta en el año 2023.
On the dependabilty function of a ⟨GIk≤n|GI|l⟩ system. Part II. Numerical study and sensitivity analysis
Authors: Rykov V. V. , Ivanova N. M.
Published: December 2024

Based on the theoretical findings presented in the first part of the paper, this part investigates the main characteristics of the dependability of a k-out-of-n system with arbitrary distributions of failure-free time and time to component repair. Using the marks transformations proposed in Part I of the paper and simulation, various probabilistic and temporal characteristics of the model are calculated and studied, while their sensitivity to the initial distributions and their parameters is analyzed.
Integrated Safety of ACS of Railway CII Facilities
Authors: Popov P. A. , Rozenberg E. N. , Sabanov A. G. , Shubinsky I. B.
Published: December 2024

The paper analyses the system of standards related to the safety of railway automated process control systems, including the key trends of standardisation for the near future. The authors examine theoretical matters of functional safety, including the safety concept of the bottom-layer transportation management process and the basic safety principles.
On the matter of explosion safety of multicomponent mixture transportation facilities
Authors: Gamera Yu. V. , Ganaga S. V. , Petrova Yu. Yu.
Published: December 2024

Given the rapid development of the oil and gas industry, the matter of assessment of the explosion resistance of buildings and structures at multicomponent gas mixture transportation and processing facilities remains of relevance. The paper investigates the sensitivity to the initiation of explosive transformation of methane and air mixtures of hydrogen and methane homologues depending on the component composition. Estimates were obtained of the sizes of detonation cells of methane and hydrogen mixtures, which allows for a more accurate definition of the class of sensitivity to detonation.
A sublime arte da arquitetura: a identidade da colônia portuguesa na Belém imperial
Authors: Salvador Miranda Cybelle
Published: December 2024

Por meio de investigação documental, busca-se neste artigo discutir a materialização da identidade portuguesa no edifício do Hospital D. Luiz I da Real Sociedade Portuguesa Beneficente, na cidade de Belém (Pará), trazendo à luz a troca de acusações entre membros da sociedade portuguesa e o arquiteto português Frederico José Branco, na qual sobressai o contexto de antilusitanismo vigente na província do Pará imperial. O monumental edifício branco, construído no bairro de Nazaré e inaugurado em 1877, permanece na atualidade como síntese de arquitetura de matriz clássica, adornado com símbolos portugueses e tendo seus valores atribuídos pela população paraense em geral.
A Comprehensive Review on Integrated Approach for Discovery and Development of Novel Bioactive Compounds: From Natural Resources to
Targeted Therapeutics
Authors: Piyushbhai Modi Kiran , Sharma Prakhar , Ramalingam Rabika , Binesh Ambika , Venkatachalam Kaliyamurthi
Published: December 2024

Background:

Bioactive compounds were isolated, characterized, but their efficacy,
potency and mechanism of action to treat/prevent several diseases yet to defined. The present review
provides the insight on the activity of nature derived bioactive compounds therapeutic potential
against communicable and non-communicable disease by using in silico approaches such
as structure-based virtual screening, ligand-based virtual screening, quantitative structure activity
relationships (QSAR) modeling, network-based methods (molecular networking) which could be
a breakthrough for the novel bioactive drug development of personalized medicine toward the
numerous diseases.

Methods:

This study conducted a thorough literature search on various computational tools used
for elucidation of bioactive compounds against communicable and non-communicable diseases.
The search was performed using multiple search engines and the main keywords, and only English
publications (Web of science, Pub med, Science direct etc.) published up to 2023 were included.

Results:

The research presented the various computational tools used for elucidation of bioactive
compounds against communicable and non-communicable diseases and possible mechanism of
action of lead compounds. It also gives the brief how computational tools might be used in future
for personalized medicine development with recently conducted studies outcome.

Conclusion:

The present review concludes that computational tools help to narrow down the hit
compounds via computational tools (virtual screening) and in short period of the time millions of
bioactive compounds could be investigated for their therapeutic potential. These review
emphasize the potential impact of computational approaches on drug development and
personalized medicine.
Chrysin: Chemistry, Occurrence, Pharmacokinetics, Toxicity, Molecular Targets, and Medicinal Properties of a Naturally Occurring Flavone
Authors: Chandra Phool , Pathak Rashmi , Sachan Neetu
Published: December 2024

The impact of naturally occurring flavonoids on human health and illnesses is crucial,
as they are closely linked to dietary components and human health. Flavonoids may be able to
shield people against disease in both in vitro and in vivo research settings. The flavonoid chrysin
has demonstrated several intriguing pharmacological properties, including immune modulation,
anti-cancer, anti-diabetic, antidepressant, and anti-asthmatic effects. Furthermore, it showed possible
defenses against various toxins in the liver, brain, kidney, and heart, among other organs.
Numerous investigations have been carried out to investigate potential targets for its potential
mechanism of action. However, because of its low oral bioavailability, its medicinal uses have
been restricted. Its broad first-pass metabolism is the leading cause of its low bioavailability.
There hasn't been a thorough discussion of the pharmacological characteristics of chrysin and the
molecular targets that are related to it yet. Therefore, this review aims to provide a comprehensive
overview of chrysin, focusing on its chemical structure, natural sources, pharmacokinetics, toxicity
profile, molecular targets, and medicinal properties. By synthesizing current research findings,
this paper aims to highlight the therapeutic potential of chrysin, discuss its safety and efficacy,
and identify areas for future research.
A Review of Newer Biologically Potent Pyridine Analogues
Authors: Mulla Mohammed Zuber D. , Siddiqui Nilofarnaznin M. , Patel Navin B. , Patel Vatsal M. , Shaikh Faiyazalam M.
Published: December 2024

Pyridine is a nitrogen-containing six-membered heterocycle that is used both independently
and fused with other heterocyclic rings such as thiazole, thiophene, and most likely
with imidazole having a wide range of biological applications. In this review, we report all possible
applications of pyridine analogs for all possible diseases. Due to various medicinal applications,
the pyridine scaffold has become a fascinating target for medicinal chemistry researchers
globally. These particular properties like basicity, water solubility, hydrogen bond forming ability,
stability, and small molecular size led researchers to pay more attention to the pyridine molecule
with different geometries such as anticancer, antitubercular, anticonvulsant, fungal, bacterial,
anti-inflammatory, antidepressant, antioxidant, anti-HIV, antidiabetic and against the COVID 19.
This review encompasses all possible applications of pyridine analogs for various diseases.