bluuebunny/crossref_metadata_2025 huggingface dataset:
New Insights of Powder Metallurgy: Microstructure, Durability and Properties
Authors: Kováčik Jaroslav , Manonukul Anchalee
Published: March 2023

This Special Issue of Materials, entitled “New Insight of Powder Metallurgy: Microstructure, Durability and Properties”, aimed to publish original and review papers on new scientific and applied research making significant contributions to our findings and understanding of the current developments and trends in powder metallurgy (PM) [...]
Study on the Influence of Saturation on Freeze–Thaw Damage Characteristics of Sandstone
Authors: Zhang Xinlei , Jin Jiaxu , Liu Xiaoli , Wang Yukai , Li Yahao
Published: March 2023

In order to explore the evolution mechanism of freeze–thaw disasters and the role of water in the freezing–thawing cycles of rocks, the macro mechanical indexes and microstructural characteristics of seven different saturation sandstones after certain freeze–thaw cycles were analyzed. Electron microscope scanning, nuclear magnetic resonance, and uniaxial compression tests were employed to study the migration law of water in the rock, the crack growth law, and the damage mechanism during freeze–thaw cycles. The results showed that when the saturation was 85%, the peak load curve of sandstone with different saturation appeared at the minimum point, and the porosity of sandstone reached the maximum. The damage variable increased sharply when the saturation was 75–85%. This proves that 85% saturation is the critical value of sandstone after five freeze–thaw cycles. The water migration freezing model is established, and the migration direction of capillary film water during freezing is micropore → mesopore → macropore. The migration of water is accompanied by the expansion and generation of cracks. Then we study the mechanism and law of crack expansion, and the crack propagation rate is positively related to the theoretical suction. The theoretical suction and theoretical ice pressure increased linearly with the decrease in temperature, which accelerated the crack propagation. The crack propagation rate in decreasing order is Vmacropore > Vmesopore > Vmicropore. The research results can provide a theoretical basis for evaluating the stability of rocks under the action of freeze–thaw cycles in cold regions.
Green Reflector with Predicted Chromatic Coordinates
Authors: Tong Xin , Yang Zhuo , Zhang Jiali , Li Wenbing , Liu Bo , Chen Chang
Published: March 2023

The color reflector with multiple-layer thin film scheme has attracted much attention because of the potential for massive production by wafer-scale deposition and the possibility to integrate with photonics (semiconductor) devices. Here, an angle-insensitive green reflector with a simple multilayer dielectric thin film structure was reported, with predicted chromatic coordinates based on CIE 1931 standard. The SiN/SiO2 multilayer thin film stack, including a special silicon-rich nitride material with ultrahigh refractive index, was grown alternatively by an inductively coupled plasma chemical vapor deposition (ICPCVD) system at a low stage temperature of 80 °C. The green reflector showed a maximum reflectivity of 73% around 561 nm with a full width at half maximum (FWHM) of 87 nm in the visible wavelength range, which contributed significantly to its color appearance. The measurement by an angle-resolved spectrometer under the illumination of p/s-polarized light wave with a variable angle of incidence indicated that the reflectance spectrum blue-shifted slightly with the increasing of incident angle such that the green color could be kept.
Low-Frequency Noise-Based Mechanism Analysis of Endurance Degradation in Al/αTiOx/Al Resistive Random Access Memory Devices
Authors: Lee Jung-Kyu , Pyo Juyeong , Kim Sungjun
Published: March 2023

In this work, we analyze a resistive switching random access memory (RRAM) device with the metal–insulator–metal structure of Al/αTiOx/Al. The transport mechanism of our RRAM device is trap-controlled space-charge limited conduction, which does not change during the endurance test. As the number of resistive switching (RS) cycles increases, the current in the low-resistance state (LRS) does not change significantly. In contrast, degradation in the high-resistance state (HRS) is noticeably evident. According to the RS cycle, the current shift fits well with the stretched-exponential equation. The normalized noise power spectral density (Si/I2) measured in the HRS is an order of magnitude higher than that in the LRS owing to the difference in the degree of trap occupancy, which is responsible for the transition of resistance states. During the consecutive RS, the Si/I2 in the HRS rapidly decreases for approximately 100 cycles and then saturates. In contrast, in the LRS, the Si/I2 does not change significantly. Here we propose a model associated with the endurance degradation of the experimental device, and the model is verified with a 1/f noise measurement.
A New Strategy on Designing Fluxes for Aluminum Alloy Melt Refinement
Authors: Zhang Guoqing , Lu Weihong , Wu Xiaocong , Yang Bo , Tan Yapeng , Xu Zhengbing , Tang Hongqun , Zeng Jianmin , Wang Junsheng
Published: March 2023

With the aim of obtaining a refining flux that is stable and provides effective refining of aluminum melt, a new strategy of designing the flux composition has been proposed. Ten fluxes were designed, by selecting ten molten salt compounds according to their thermophysical parameters, physical properties, and thermodynamic analysis. The melting points of the ten fluxes, and the phases transformation of the fluxes after melting, were studied by DSC and XRD, respectively. The contact angles between four groups of fluxes and alumina at refinement temperatures were studied, and the effect of refinement was characterized by a metallographic microscope. The process of the fluxes removing inclusions and degassing was analyzed thermodynamically. The research findings indicate that flux #10 (11.0 wt.%NaF, 29.5 wt.%NaCl, 46.5 wt.%Na2CO3, 3.0 wt.%CaF2, 10.0 wt.%Na3AlF6) has a melting point (562.2 °C) below the refining temperature. At the refining temperature (760 °C), flux #10 has the lowest contact angle, of 12.78°. In addition, compared to that of flux STJ–A3, currently used in practice, flux #10 has a better refining effectiveness, with the pores and inclusions content of the sample being reduced to 1.11% from 2.96%.
Wet-Oxidation-Assisted Chemical Mechanical Polishing and High-Temperature Thermal Annealing for Low-Loss 4H-SiC Integrated Photonic Devices
Authors: Shi Xiaodong , Lu Yaoqin , Chaussende Didier , Rottwitt Karsten , Ou Haiyan
Published: March 2023

Silicon carbide (SiC) has become a promising optical material for quantum photonics and nonlinear photonics during the past decade. In this work, we propose two methods to improve the 4H-SiC thin film quality for SiC integrated photonic chips. Firstly, we develop a wet-oxidation-assisted chemical mechanical polishing (CMP) process for 4H-SiC, which can significantly decrease the surface roughness from 3.67 nm to 0.15 nm, thus mitigating the light scattering loss. Secondly, we find that the thermal annealing of the 4H-SiC devices at 1300 °C can help to decrease the material absorption loss. We experimentally demonstrate that the wet-oxidation-assisted CMP and the high-temperature annealing can effectively increase the intrinsic quality factor of the 4H-SiC optical microring resonators.
The Incidence of Retrograde Peri-Implantitis in a Single University Dental Hospital Training Center: A Retrospective Analysis
Authors: Alssum Lamees R. , Alghofaily Maha M. , Aleyiydi Asrar S. , Alomar Sadeem A. , Alsalleeh Fahd M.
Published: March 2023

Background and objective: Retrograde peri-implantitis (RPI) is a periapical radiolucent lesion developed around the implant apex. This study aimed to investigate the Incidence of RPI in a single university dental hospital training center. Materials and Methods: All records of patients who received single Implants between 2016–2020 were screened. For cases that met inclusion criteria, clinical and radiographic data were analyzed. Results: A total of 215 were included and categorized as follows, Category A: implants were placed next to endodontically treated teeth (n = 58, 27%); category B, implants placed at the sites with previous endodontic involvement within 6 months of tooth extraction (n = 25, 11.6%); Category AB: implants placed at sites that fulfill the criteria of groups A and B (n = 18, 8.4%); and Category C: Implants that were placed next to vital teeth and at a site with no previous endodontic treatment or a site that was allowed to heal for more than six (n = 114, 53%). Categories A, B and AB served as the endodontically involved (EI) group, while category C served as non- endodontically involved (NEI) group. Only two sites (0.9%) were confirmed as RPI, both from group A (3.4%). Comparing all groups studied showed no statistically significant difference in RPI incidence. Conclusions: The incidence of RPI is low; however, endodontically treated teeth with periapical lesions (PALs) next to an implant site could contribute to RPI.
Emotional and Social Impact of Halitosis on Adolescents and Young Adults: A Systematic Review
Authors: Briceag Raluca , Caraiane Aureliana , Raftu Gheorghe , Horhat Razvan Mihai , Bogdan Iulia , Fericean Roxana Manuela , Shaaban Luai , Popa Malina , Bumbu Bogdan Andrei , Bratu Melania Lavinia , Pricop Marius , Talpos Serban
Published: March 2023

Background and Objectives: Halitosis is a condition characterized by unpleasant breath smell that is starting to receive serious scientific attention, considering it reflects on people’s social and personal life. While most studies focus on the prevalence of halitosis, its medical etiology, and the psychological impact on adults, there is a lack of evidence regarding the social impact of halitosis on the younger population. Therefore, this systematic review aimed to observe the social and emotional impact that halitosis has on adolescents and young adults. Materials and Methods: The review followed the PRISMA protocol, and four electronic databases (Scopus, Scholar, Web of Science, and ProQuest) were searched. From a total of 593 studies retrieved, only 6 were included in the study after assessing the eligibility criteria. Results: The main results showed that the levels of self-reported halitosis ranged from 23.1% to 77.5%, with an average of 44.7%, indicating a significant heterogeneity among the studies reporting this issue. Adolescents and young adults who experienced bad breath were feeling more anxious and depressed according to the non-standardized questionnaires and the standardized questionnaires (OHIP-14 and SCL-9-R). The respondents were isolated from social interactions and consequently had lower self-esteem and impaired quality of life. Conclusions: The conclusions drawn indicate the need for action on a medical level, as well as on a psychological level, in order to improve people’s oral health and help them navigate through the difficulties of maintaining social interactions as they live with halitosis.
Pituitary Abscess: A Challenging Preoperative Diagnosis—A Multicenter Study
Authors: Mallereau Charles-Henry , Todeschi Julien , Ganau Mario , Cebula Hélène , Bozzi Maria Teresa , Romano Antonio , Le Van Tuan , Ollivier Irene , Zaed Ismail , Spatola Giorgio , Nannavecchia Beniamino , Mahoudeau Pierre , Djennaoui Idir , Debry Christian , Signorelli Francesco , Ligarotti Gianfranco K. I. , Pop Raoul , Baloglu Seyyid , Fasciglione Elsa , Goichot Bernard , Bund Caroline , Gaudias Jeannot , Proust Francois , Chibbaro Salvatore
Published: March 2023

Background and Objectives: Pituitary abscess (PA) is a rare occurrence, representing less than 1% of pituitary lesions, and is defined by the presence of an infected purulent collection within the sella turcica. Pas can be classified as either primary, when the underlying pituitary is normal prior to infection, or secondary, when there is associated a pre-existing sellar pathology (i.e., pituitary adenoma, Rathke’s cleft cysts, or craniopharyngioma), with or without a recent history of surgery. Preoperative diagnosis, owing to both non-specific symptoms and imaging features, remains challenging. Treatment options include endonasal trans-sphenoidal pus evacuation, as well as culture and tailored antibiotic therapy. Methods: A retrospective multicenter study, conducted on a prospectively built database over a 20-year period, identified a large series of 84 patients harboring primary sellar abscess. The study aimed to identify crucial clinical and imaging features in order to accelerate appropriate management. Results: The most common clinical presentation was a symptom triad consisting of various degrees of asthenia (75%), visual impairment (71%), and headache (50%). Diagnosis was achieved in 95% of cases peri- or postoperatively. Functional recovery was good for visual disturbances and headache. Pituitary function recovery remained very poor (23%), whereas the preoperative diagnosis represented a protective factor. Conclusions: In light of the high prevalence of pituitary dysfunction following the management of PAs, early diagnosis and treatment might represent a crucial issue. Currently, there are no standard investigations to establish a conclusive preoperative diagnosis; however, new, emerging imaging methods, in particular nuclear imaging modalities, represent a very promising tool, whose potential warrants further investigations.
Interlayer-Expanded MoS2 Enabled by Sandwiched Monolayer Carbon for High Performance Potassium Storage
Authors: Zhang Yuting , Zhu Lin , Xu Hongqiang , Wu Qian , Duan Haojie , Chen Boshi , He Haiyong
Published: March 2023

Potassium-ion batteries (PIBs) have aroused a large amount of interest recently due to the plentiful potassium resource, which may show cost benefits over lithium-ion batteries (LIBs). However, the huge volume expansion induced by the intercalation of large-sized potassium ions and the intrinsic sluggish kinetics of the anode hamper the application of PIBs. Herein, by rational design, nano-roses assembled from petals with a MoS2/monolayer carbon (C-MoS2) sandwiched structure were successfully synthesized. The interlayer distance of ultrathin C-MoS2 was expanded from original MoS2 of 6.2 to 9.6 Å due to the formation of the MoS2-carbon inter overlapped superstructure. This unique structure efficiently alleviates the mechanical strain, prevents the aggregation of MoS2, creates more active sites, facilitates electron transport, and enhances the specific capacity and K+ diffusion kinetics. As a result, the prepared C-MoS2-1 anode delivers a high reversible specific capacity (437 mAh g−1 at 0.1 A g−1) and satisfying rate performance (123 mAh g−1 at 6.4 A g−1). Therefore, this work provides new insights into the design of high-performance anode materials of PIBs.
Synthesis and Structure–Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
Authors: Yang Yazhou , Zhou Yujie , Jiang Qiaoju , Tan Yi , Wu Wenbin , Han Ke , Zhu Rui , Zheng Shaojun
Published: March 2023

A total of 39 novel cyclotryptamine alkaloid derivatives were prepared from 2-(1H-indol-3-yl) acetonitrile. The prepared compounds were evaluated against six plant pathogen fungi. Bioassay results revealed that most of the compounds displayed higher in vitro antifungal activities than the positive control. Notably, compound b2 displayed the broadest and most effective activity among the tested cyclotryptamine alkaloid derivatives and might be a novel potential leading compound for further development as an antifungal agent.
Quorum Quenchers from Reynoutria japonica in the Battle against Methicillin-Resistant Staphylococcus aureus (MRSA)
Authors: Fatima Maliha , Amin Arshia , Alharbi Metab , Ishtiaq Sundas , Sajjad Wasim , Ahmad Faisal , Ahmad Sajjad , Hanif Faisal , Faheem Muhammad , Khalil Atif Ali Khan
Published: March 2023

Over the past decade, methicillin-resistant Staphylococcus aureus (MRSA) has become a major source of biofilm formation and a major contributor to antimicrobial resistance. The genes that govern biofilm formation are regulated by a signaling mechanism called the quorum-sensing system. There is a need for new molecules to treat the infections caused by dangerous pathogens like MRSA. The current study focused on an alternative approach using juglone derivatives from Reynoutria japonica as quorum quenchers. Ten bioactive compounds from this plant, i.e., 2-methoxy-6-acetyl-7-methyljuglone, emodin, emodin 8-o-b glucoside, polydatin, resveratrol, physcion, citreorosein, quercetin, hyperoside, and coumarin were taken as ligands and docked with accessory gene regulator proteins A, B, and C and the signal transduction protein TRAP. The best ligand was selected based on docking score, ADMET properties, and the Lipinski rule. Considering all these parameters, resveratrol displayed all required drug-like properties with a docking score of −8.9 against accessory gene regulator protein C. To further assess the effectiveness of resveratrol, it was compared with the commercially available antibiotic drug penicillin. A comparison of all drug-like characteristics showed that resveratrol was superior to penicillin in many aspects. Penicillin showed a binding affinity of −6.7 while resveratrol had a score of −8.9 during docking. This was followed by molecular dynamic simulations wherein inhibitors in complexes with target proteins showed stability inside the active site during the 100 ns simulations. Structural changes due to ligand movement inside the cavity were measured in the protein targets, but they remained static due to hydrogen bonds. The results showed acceptable pharmacokinetic properties for resveratrol as compared to penicillin. Thus, we concluded that resveratrol has protective effects against Staphylococcus aureus infections and that it suppresses the quorum-sensing ability of this bacterium by targeting its infectious proteins.
Comparative Bioactivity Evaluation of Chemically Characterized Essential Oils Obtained from Different Aerial Parts of Eucalyptus gunnii Hook. f. (Myrtaceae)
Authors: Abbaci Hocine , Nabti El-hafid , Al-Bekairi Abdullah M. , Hagras Soheir A. A. , Salem-Bekhit Mounir M. , Adjaoud Abdenour , Alzahrani Hayat Ali , Bensidhoum Leila , Alenazy Rawaf , Piras Alessandra , Falconieri Danilo , Porcedda Silvia , Benguerba Yacine , Houali Karim
Published: March 2023

Essential oils (EOs) obtained by hydro-distillation from different parts of twigs (EOT), leaves (EOL), and fruits (EOF) of Eucalyptus gunnii Hook. f. were screened for their chemical composition, insecticidal, repellence, and antibacterial properties. Based on GC and GC/MS analysis, 23 constituents were identified across the twigs, leaves, and fruits, with 23, 23, and 21 components, respectively. The primary significant class was oxygenated monoterpenes (82.2–95.5%). The main components were 1,8-cineole (65.6–86.1%), α-terpinyl acetate (2.5–7.6%), o-cymene (3.3–7.5%), and α-terpineol (3.3–3.5%). All three EOs exhibited moderate antibacterial activities. EOL was found to have higher antibacterial activity against all tested strains except Dickeya solani (CFBP 8199), for which EOT showed more potency. Globally, Dickeya solani (CFBP 8199) was the most sensitive (MIC ≤ 2 mg/mL), while the most resistant bacteria were Dickeya dadantii (CFBP 3855) and Pectobacterium carotovorum subsp. carotovorum (CFBP 5387). Fumigant, contact toxicity, and repellent bioassays showed different potential depending on plant extracts, particularly EOT and EOL as moderate repellents and EOT as a medium toxicant.
Anti-Inflammatory and Gut Microbiota Modulating Effects of Probiotic Lactobacillus paracasei MSMC39-1 on Dextran Sulfate Sodium-Induced Colitis in Rats
Authors: Ladda Boonyarut , Jantararussamee Chittapon , Pradidarcheep Wisuit , Kasorn Anongnard , Matsathit Udomlak , Taweechotipatr Malai
Published: March 2023

Probiotics have been shown to possess several properties, depending on the strain. Some probiotics have important roles in preventing infection and balancing the immune system due to the interaction between the intestinal mucosa and cells in the immune system. This study aimed to examine the properties of three probiotic strains using the tumor necrosis factor-alpha (TNF-α) inhibition test in colorectal adenocarcinoma cells (Caco-2 cells). It was revealed that the viable cells and heat-killed cells of the probiotic L. paracasei strain MSMC39-1 dramatically suppressed TNF-α secretion in Caco-2 cells. The strongest strains were then chosen to treat rats with colitis induced by dextran sulfate sodium (DSS). Viable cells of the probiotic L. paracasei strain MSMC39-1 reduced aspartate transaminase and alanine transaminase in the serum and significantly inhibited TNF-α secretion in the colon and liver tissues. Treatment with the probiotic L. paracasei strain MSMC39-1 alleviated the colon and liver histopathology in DSS-induced colitis rats. Furthermore, supplementation with probiotic L. paracasei strain MSMC39-1 increased the genus Lactobacillus and boosted the other beneficial bacteria in the gut. Thus, the probiotic L. paracasei strain MSMC39-1 exhibited an anti-inflammation effect in the colon and modulated the gut microbiota.
Soy Extract, Rich in Hydroxylated Isoflavones, Exhibits Antidiabetic Properties In Vitro and in Drosophila melanogaster In Vivo
Authors: Lüersen Kai , Fischer Alexandra , Bauer Ilka , Huebbe Patricia , Uekaji Yukiko , Chikamoto Keita , Nakata Daisuke , Hiramatsu Naoto , Terao Keiji , Rimbach Gerald
Published: March 2023

In the context of the growing prevalence of type 2 diabetes (T2DM), control of postprandial hyperglycemia is crucial for its prevention. Blood glucose levels are determined by various factors including carbohydrate hydrolyzing enzymes, the incretin system and glucose transporters. Furthermore, inflammatory markers are recognized predictors of diabetes outcome. Although there is some evidence that isoflavones may exhibit anti-diabetic properties, little is known about to what extent their corresponding hydroxylated metabolites may affect glucose metabolism. We evaluated the ability of a soy extract before (pre-) and after (post-) fermentation to counteract hyperglycemia in vitro and in Drosophila melanogaster in vivo. Fermentation with Aspergillus sp. JCM22299 led to an enrichment of hydroxy-isoflavones (HI), including 8-hydroxygenistein, 8-hydroxyglycitein and 8-hydroxydaidzein, accompanied by an enhanced free radical scavenging activity. This HI-rich extract demonstrated inhibitory activity towards α-glucosidase and a reduction of dipeptidyl peptidase-4 enzyme activity. Both the pre- and post-fermented extracts significantly inhibited the glucose transport via sodium-dependent glucose transporter 1. Furthermore, the soy extracts reduced c-reactive protein mRNA and secreted protein levels in interleukin-stimulated Hep B3 cells. Finally, supplementation of a high-starch D. melanogaster diet with post-fermented HI-rich extract decreased the triacylglyceride content of female fruit flies, confirming its anti-diabetic properties in an in vivo model.
Temporal Trend of Multimorbidity of Noncommunicable Diseases among Brazilian Adults, 2006–2021
Authors: Caldeira Thaís C. M. , Sousa Taciana M. , Soares Marcela M. , Veiga Izabella P. A. , Silva Luiza E. S. , Claro Rafael M.
Published: March 2023

We aimed to identify the temporal trend of multimorbidity of noncommunicable disease (NCDs) among Brazilian adults (n = 784,479) over a 16-year period of time. This is a time series of cross-sectional studies based on data from the Surveillance System of Risk and Protective Factors for Chronic Diseases by Telephone Survey (Vigitel) from 2006 to 2021. The presence of multimorbidity was assessed from the co-occurrence of (1) obesity and diabetes; (2) obesity and hypertension; and (3) obesity and diabetes and/or hypertension. Linear regression models (Prais–Winsten) were used to identify significant trends for the complete period (2006–2021) and the most recent quinquennium (2017–2021). Multimorbidity of obesity and diabetes and/or hypertension increased in the complete period (5.5% to 9.6%; 0.22 pp/year) and the most recent period (8.3% to 9.6%; 0.40 pp/year) studied. The highest increase occurred especially among men, older adults, and those with fewer years of education. Additionally, there was a high prevalence and an intense increase in multimorbidity among adults with poor self-rated health. These results reinforce the need for expanding and strengthening public health actions focused on individuals with multimorbidity especially with obesity.
The Effect of Quantum Noise on Multipartite Entanglement from a Cascaded Parametric Amplifier
Authors: Wang Hailong , Zhang Yajuan , Zhang Xiong , Chen Jun , Gong Huaping , Zhao Chunliu
Published: March 2023

The tripartite entanglement generated from a cascaded parametric amplifier is always present in the whole gain region in the ideal condition. However, in practical applications, the quantum entanglement is very fragile and easily deteriorated by quantum noise from interactions with external environments, e.g., the avoidable attenuation and amplification operations may lead to some degradation effects on the quantum entanglement. Therefore, in this work, bipartite entanglement for the three pairs and tripartite entanglement in this cascaded parametric amplifier under the circumstances of attenuation and amplification operations are analyzed by using positivity under partial transposition criterion. The results show that tripartite entanglement is robust to the deterioration effects from the attenuation and amplification operations rather than bipartite entanglement. Our results may find some practical applications of multipartite quantum entanglement in quantum secure communications.
Does Cannabidiol (CBD) in Food Supplements Pose a Serious Health Risk? Consequences of the European Food Safety Authority (EFSA) Clock Stop Regarding Novel Food Authorisation
Authors: Lachenmeier Dirk W. , Sproll Constanze , Walch Stephan G.
Published: March 2023

In the European Union (EU), cannabidiol (CBD) products extracted from Cannabis sativa L. require pre-marketing authorisation under the novel food regulation. Currently, 19 CBD applications are being assessed by the European Food Safety Authority (EFSA). During the initial assessment of the dossiers, the EFSA Panel on Nutrition, Novel Foods, and Food Allergens (NDA) identified several knowledge gaps that need to be addressed before the evaluation of CBD can be finalised. The effects of CBD on the liver, gastrointestinal tract, endocrine system, nervous system, psychological function, and reproductive system need to be clarified. The contribution of this research is to provide an evidence-based assessment of the potential risks associated with CBD products, and to provide recommendations for risk management in the European Union while awaiting the finalisation of novel food applications. The available literature allows for a benchmark dose (BMD)–response modelling of several bioassays, resulting in a BMD lower confidence limit (BMDL) of 20 mg/kg bw/day for liver toxicity in rats. Human data in healthy volunteers showed increases in the liver enzymes alanine aminotransferase and aspartate aminotransferase in one study at 4.3 mg/kg bw/day, which was defined by the EFSA NDA panel as the lowest observed adverse effect level (LOAEL). The EFSA NDA panel recently concluded that the safety of CBD as a novel food cannot be assessed, resulting in a so-called clock stop for the applications until the applicants provide the required data. The authors suggest that certain CBD products still available on the EU market as food supplements despite the lack of authorisation should be considered “unsafe”. Products exceeding a health-based guidance value (HBGV) of 10 mg/day should be considered “unfit for consumption” (Article 14(1) and (2)(b) of Regulation No. 178/2002), while those exceeding the human LOAEL should be considered “injurious to health” (Article 14(1) and (2)(a) of Regulation No 178/2002).
Evaluation of Polarization Observation Accuracy of SGLI VNR-PL Using In-Orbit Calibration Data
Authors: Tsuida Shunji , Yoshida Jun , Amano Takahiro , Tanaka Kazuhiro
Published: March 2023

The Second Generation Global Imager (SGLI) on the Global Change Observation Mission—Climate (GCOM-C) “SHIKISAI” has polarization observation channels at wavelengths of red (673.5 nm—P1) and near infrared (868.5 nm—P2), and it is expected to extract information of aerosols on land with higher accuracy than conventional observation methods by utilizing the scattering by atmospheric particles obtained by polarization observation. The polarization observation of SGLI adopts a method to derive the Stokes parameters I, Q, and U by observing three polarized azimuths. In this paper, the polarization observation accuracy means the polarization degree accuracy and polarization azimuth accuracy, which can be expressed as a relative value of I, Q, and U, and does not include the accuracy of radiance. In order to evaluate the polarization observation accuracy of SGLI on orbit, variations of the Q/I and U/I have been investigated using three kinds of calibration data. The effects of calibration methods and aging have been successfully eliminated by comparing independent evaluations of three kinds of calibration data. As a result, it was concluded that the variations of Q/I and U/I are achieved within a slight variation range of ±0.07% at the P1 telescope and ±0.04% at the P2 telescope.
The Potential of New LiDAR Datasets for Archaeology in Switzerland
Authors: Caspari Gino
Published: March 2023

LiDAR and its derived elevation models have revolutionized archaeological research in forested areas around the globe. Almost a third of Switzerland is covered in forests. The number of archaeological sites recorded in forests in Switzerland is, however, limited. Given these circumstances, it is surprising how underutilized LiDAR data are in archaeological research in the country. As the Federal Office of Topography swisstopo is finalizing the acquisition of new LiDAR datasets, increasing the covered area and allowing for limited time series analyses, these data should be used to the fullest extent. This article describes the open access datasets and elaborates on their potential for archaeological research and cultural heritage management. By employing LiDAR data on a large scale, Swiss archaeological research would likely substantially increase the number of recorded heritage sites. Additionally, this will have the effect of complementing the palimpsests of past anthropogenic activity throughout the landscape while reducing survey biases in the archaeological record.
Self-Scheduled LPV Control of Asymmetric Variable-Span Morphing UAV
Authors: Lee Jihoon , Kim Seong-Hun , Lee Hanna , Kim Youdan
Published: March 2023

In this study, a novel framework for the flight control of a morphing unmanned aerial vehicle (UAV) based on linear parameter-varying (LPV) methods is proposed. A high-fidelity nonlinear model and LPV model of an asymmetric variable-span morphing UAV were obtained using the NASA generic transport model. The left and right wing span variation ratios were decomposed into symmetric and asymmetric morphing parameters, which were then used as the scheduling parameter and the control input, respectively. LPV-based control augmentation systems were designed to track the normal acceleration, angle of sideslip, and roll rate commands. The span morphing strategy was investigated considering the effects of morphing on various factors to aid the intended maneuver. Autopilots were designed using LPV methods to track commands for airspeed, altitude, angle of sideslip, and roll angle. A nonlinear guidance law was coupled with the autopilots for three-dimensional trajectory tracking. A numerical simulation was performed to demonstrate the effectiveness of the proposed scheme.
Head-Mounted Display for Clinical Evaluation of Neck Movement Validation with Meta Quest 2
Authors: Trinidad-Fernández Manuel , Bossavit Benoît , Salgado-Fernández Javier , Abbate-Chica Susana , Fernández-Leiva Antonio J. , Cuesta-Vargas Antonio I.
Published: March 2023

Neck disorders have a significant impact on people because of their high incidence. The head-mounted display (HMD) systems, such as Meta Quest 2, grant access to immersive virtual reality (iRV) experiences. This study aims to validate the Meta Quest 2 HMD system as an alternative for screening neck movement in healthy people. The device provides data about the position and orientation of the head and, thus, the neck mobility around the three anatomical axes. The authors develop a VR application that solicits participants to perform six neck movements (rotation, flexion, and lateralization on both sides), which allows the collection of corresponding angles. An InertiaCube3 inertial measurement unit (IMU) is also attached to the HMD to compare the criterion to a standard. The mean absolute error (MAE), the percentage of error (%MAE), and the criterion validity and agreement are calculated. The study shows that the average absolute errors do not exceed 1° (average = 0.48 ± 0.09°). The rotational movement’s average %MAE is 1.61 ± 0.82%. The head orientations obtain a correlation between 0.70 and 0.96. The Bland–Altman study reveals good agreement between the HMD and IMU systems. Overall, the study shows that the angles provided by the Meta Quest 2 HMD system are valid to calculate the rotational angles of the neck in each of the three axes. The obtained results demonstrate an acceptable error percentage and a very minimal absolute error when measuring the degrees of neck rotation; therefore, the sensor can be used for screening neck disorders in healthy people.
Real-Time 6-DOF Pose Estimation of Known Geometries in Point Cloud Data
Authors: Bhandari Vedant , Phillips Tyson Govan , McAree Peter Ross
Published: March 2023

The task of tracking the pose of an object with a known geometry from point cloud measurements arises in robot perception. It calls for a solution that is both accurate and robust, and can be computed at a rate that aligns with the needs of a control system that might make decisions based on it. The Iterative Closest Point (ICP) algorithm is widely used for this purpose, but it is susceptible to failure in practical scenarios. We present a robust and efficient solution for pose-from-point cloud estimation called the Pose Lookup Method (PLuM). PLuM is a probabilistic reward-based objective function that is resilient to measurement uncertainty and clutter. Efficiency is achieved through the use of lookup tables, which substitute complex geometric operations such as raycasting used in earlier solutions. Our results show millimetre accuracy and fast pose estimation in benchmark tests using triangulated geometry models, outperforming state-of-the-art ICP-based methods. These results are extended to field robotics applications, resulting in real-time haul truck pose estimation. By utilising point clouds from a LiDAR fixed to a rope shovel, the PLuM algorithm tracks a haul truck effectively throughout the excavation load cycle at a rate of 20 Hz, matching the sensor frame rate. PLuM is straightforward to implement and provides dependable and timely solutions in demanding environments.
The Development of a Data Collection and Browser Fingerprinting System
Authors: Pau Kiu Nai , Lee Vicki Wei Qi , Ooi Shih Yin , Pang Ying Han
Published: March 2023

The urgent need to protect user privacy and security has emerged as the World Wide Web has become an increasingly necessary part of daily life. Browser fingerprinting is a very interesting topic in the industry of technology security. New technology will always raise new security issues and browser fingerprinting will undoubtedly follow the same process. It has become one of the most popular topics in online privacy because, to date, there is still no exact solution as to how to stop it entirely. The majority of solutions just aim to reduce the likelihood of obtaining a browser fingerprint. Research on browser fingerprinting is unquestionably required since it is essential to educate users, developers, policymakers, and law enforcement about it so that they can make strategic choices based on knowledge. Browser fingerprinting must be recognised in order to defend against privacy problems. A browser fingerprint is described as data gathered by the receiving server to identify a distant device, and it is different from cookies. Websites frequently utilize browser fingerprinting to obtain information about the type and version of the browser, as well as the operating system, and other current settings. It has been known that even when cookies are disabled, fingerprints can be used to fully or partially identify users or devices. In this communication paper, a new insight into the challenge of browser fingerprint is encouraged as a new venture. Thus, the initial way to truly understand the browser fingerprint is the need to collect browser fingerprints. In this work, the process of data collection for browser fingerprinting through scripting, to offer a complete all-in-one fingerprinting test suite, has been thoughtfully divided into appropriate sections and grouped with key information to be carried out. The objective is to gather fingerprint data with no personal identification information and make it an open source of raw datasets in the industry for any future research purposes. To our best knowledge, there are no open datasets made available for browser fingerprints in the research field. The dataset will be widely accessible by anyone interested in obtaining those data. The dataset collected will be very raw and will be in the form of a text file. Thus, the main contribution of this work is to share an open dataset of browser fingerprints along with its collection methodology.
Diagnostic Process of an Ancient Colonnade Using 3D High-Resolution Models with Non-Invasive Multi Techniques
Authors: Casula Giuseppe , Fais Silvana , Cuccuru Francesco , Bianchi Maria Giovanna , Ligas Paola
Published: March 2023

Here, an avant-garde study of three ancient Doric columns of the precious, ancient Romanesque church of Saints Lorenzo and Pancrazio in the historical town center of Cagliari (Italy) is presented based on the integrated application of different non-destructive testing methods. The limitations of each methodology are overcome by the synergistic application of these methods, affording an accurate, complete 3D image of the studied elements. Our procedure begins with a macroscopic in situ analysis to provide a preliminary diagnosis of the conditions of the building materials. The next step is laboratory tests, in which the porosity and other textural characteristics of the carbonate building materials are studied by optical and scanning electron microscopy. After this, a survey with a terrestrial laser scanner and close-range photogrammetry is planned and executed to produce accurate high-resolution 3D digital models of the entire church and the ancient columns inside. This was the main objective of this study. The high-resolution 3D models allowed us to identify architectural complications occurring in historical buildings. The 3D reconstruction with the above metric techniques was indispensable for planning and carrying out the 3D ultrasonic tomography, which played an important role in detecting defects, voids, and flaws within the body of the studied columns by analyzing the propagation of the ultrasonic waves. The high-resolution 3D multiparametric models allowed us to obtain an extremely accurate picture of the conservation state of the studied columns in order to locate and characterize both shallow and internal defects in the building materials. This integrated procedure can aid in the control of the spatial and temporal variations in the materials’ properties and provides information on the process of deterioration in order to allow adequate restoration solutions to be developed and the structural health of the artefact to be monitored.
Multi-Objective Path Optimization in Fog Architectures Using the Particle Swarm Optimization Approach
Authors: Morkevičius Nerijus , Liutkevičius Agnius , Venčkauskas Algimantas
Published: March 2023

IoT systems can successfully employ wireless sensor networks (WSNs) for data gathering and fog/edge computing for processing collected data and providing services. The proximity of edge devices to sensors improves latency, whereas cloud assets provide higher computational power when needed. Fog networks include various heterogeneous fog nodes and end-devices, some of which are mobile, such as vehicles, smartwatches, and cell phones, while others are static, such as traffic cameras. Therefore, some nodes in the fog network can be randomly organized, forming a self-organizing ad hoc structure. Moreover, fog nodes can have different resource constraints, such as energy, security, computational power, and latency. Therefore, two major problems arise in fog networks: ensuring optimal service (application) placement and determining the optimal path between the user end-device and the fog node that provides the services. Both problems require a simple and lightweight method that can rapidly identify a good solution using the constrained resources available in the fog nodes. In this paper, a novel two-stage multi-objective path optimization method is proposed that optimizes the data routing path between the end-device and fog node(s). A particle swarm optimization (PSO) method is used to determine the Pareto Frontier of alternative data paths, and then the analytical hierarchy process (AHP) is used to choose the best path alternative according to the application-specific preference matrix. The results show that the proposed method works with a wide range of objective functions that can be easily expanded. Moreover, the proposed method provides a whole set of alternative solutions and evaluates each of them, allowing us to choose the second- or third-best alternative if the first one is not suitable for some reason.
Barriers in Sustainability of Dental Students Choosing Academic Career Path: Comparison between the United States and Japan
Authors: Asano Akiko , Maeno Masahiko , Zhou Xixi , Sasaki Daisuke , Kuwajima Yukinori , Ishida Yoshiki , Nakamura Takehito , Kobayashi Kenichiro , Hojo Yasushi , Nagai Shigemi
Published: March 2023

The purpose of this study is to investigate barriers experienced by dental students when choosing professional careers. An anonymous online survey with eight questions extracted from the annual American Dental Education Association Survey for U.S. dental school seniors (UDS) and two Japan-specific questions was given to Japanese dental school seniors (JDS) in 2019, 2020, and 2021. The results were compared to UDS data. This study was approved by the Institutional Review Board of Harvard Medical School and included 1053 respondents. The parental education and income levels of JDS were higher than UDS, and educational debt of JDS was lower than UDS. The top reason for choosing dentistry for JDS was influence and expectation from family members, while the top reason for UDS was service to others. Although both groups showed interest in teaching in academia, the majority chose to enter private practice immediately post-graduation, and would consider teaching during their mid or late career. Barriers for dental students staying in academia varied between the two countries. For JDS, the main barrier was an anxiety around stable income. For UDS, it was their educational debt. Dental educators and policymakers need to consider these barriers to improve the sustainability of dental students choosing an academic career path.
Simulation and Prediction of Territorial Spatial Layout at the Lake-Type Basin Scale: A Case Study of the Dongting Lake Basin in China from 2000 to 2050
Authors: Luo Ziwei , Hu Xijun , Wang Yezi , Chen Cunyou
Published: March 2023

The study of spatial layout in China is changing from land use/land cover to territorial spatial layout and is mostly carried out at the administrative division scale. However, the driving factors affecting the evolution of territorial spatial layout are not all influenced by administrative boundaries. As cities are mostly centered on lakes and water systems, the evolution of territorial spatial layout in lake-type basins must have its own special characteristics. Taking the Dongting Lake Basin (DLB), a representative lake-type basin in China, as an example, this study identifies its territorial spatial layout elements and couples the system dynamics model with the patch-generating land-use simulation model based on multi-layer perceptron artificial neural networks. This study identified the best combination of driving factors and research step size affecting the evolution of territorial spatial layout. An improved quantitative spatial coupling model was used to simulate the territorial spatial layout of the DLB from 2000 to 2050 and identify its evolutionary characteristics and trends at both the elemental level and for three types of space. The simulation and prediction of territorial spatial layout from the lake-type basin hydrology scale can provide a reference for the formulation of regional territorial spatial planning policies.
Sustainable Development Goals in the Business Sphere: A Bibliometric Review
Authors: Martínez-Falcó Javier , Marco-Lajara Bartolomé , Sánchez-García Eduardo , Millan-Tudela Luis A.
Published: March 2023

Academic contributions on the impact of the Sustainable Development Goals (SDGs) on businesses have grown exponentially in recent years as a result of the importance of the business sector in improving the economy, society and the environment. Through the use of bibliometric methods and taking the Web of Science (WoS) as a reference database, the research aims to analyze the structure of scientific knowledge of the link between the SDGs and the corporate sector, analyzing 2366 documents published between 1992 and 2022. The results show, among other aspects, the accelerated growth rate of the scientific production analyzed since 2015, the use of publications in articles as the main format for disseminating research results, the relevance of the category of Environmental Sciences as the area of study in which most of the scientific production analyzed falls as well as the predominant role of the publishing houses MDPI, Elsevier and Emerald in the publication of scientific documents on the topic under analysis. The research can therefore be of use to both neophyte and experienced researchers who wish to deepen their understanding of the academic knowledge structure of the SDGs in the business world.
Ecosystem Services Research in Rural Areas: A Systematic Review Based on Bibliometric Analysis
Authors: Ge Beichen , Wang Congjin , Song Yuhong
Published: March 2023

As an essential part of ecosystem services, the rural ecosystem service (rES) plays an irreplaceable role in sustainable development. However, research on rESs still needs improvement compared with urban ecosystem services. Aiming at analyzing the research and development trends in rES, three types of bibliometric analysis software, HistCite, VOSviewer, and CiteSpace, are applied to reveal and visualize the research status and the prospect of existing research. The results show that since 2015, there has been a significant increase in the number of countries, papers, and institutions studying rES. There are five main research areas, among which urbanization and nature’s contribution to people (NCP) are ongoing. Moreover, the research content gradually shifted from fundamental studies on the relationship between biodiversity and ecosystem services to the relationships between different stakeholders and rESs against the background of complex social relations and cultural settings in urbanization. However, there is still a lack of leading ancestor literature in the field, and this field still needs to be developed.