bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Types of Errors in College Student Writing : Focused on the Students' Text
Authors:   The Korean Society of Culture and Convergence, Nho Eunjoo , Choi Seonhui
Published: January 2023

The purpose of this study is to analyze the types of various error cases commonly found in college students' writing, draw problems and guide them, thereby contributing to the future students' correct self-expression through writing and smooth communication with each other.. Therefore, in this paper, the students' writings written by new students through various programs related to writing classes and writing subjects are targeted in this paper. In the writing curriculum of the school's new students in the Class of 2021, errors in vocabulary and sentences including typography were examined. There are a total of 75 error writings, and errors were derived from essays on various topics, and the characteristics were considered by classifying them into typographical and sentence errors.Errors related to notation accounted for 20.7% of the total, and 79.3% of sentence errors appeared.Among sentence errors, colloquial expression errors and research errors were high at 16.6% and 16.2%, respectively.
The Newness of A. Schoenberg’s Twelve-Tone Technique Interpreted through M. Csikszentmihalyi’s Systems Model
Authors:   The Korean Society of Culture and Convergence, Kim Heejin
Published: January 2023

At a time when the creation of new ideas and new products is considered more important than ever, this research reconsiders the role of the cultural domain in producing the future. As seen in the case of the twelve-tone technique provided by Arnold Schoenberg, which is considered a significant new one that exerted notable influence on contemporary music but which is explained as a continuation of the past by the composer himself, newness can be understood as a variant inherited from the past and what is embedded in the accumulation of preexisting cultural products and practices. For this discussion, “A Systems Model” suggested by Mihaly Csikszentmihalyi is explored. This paper argues for the significance of the cultural practices and products from the past for the creation of newness. By doing so, this research contributes to balancing the pursuit of newness with the consideration of the value of what is transmitted from the past, and suggests a way to elaborate Csikszentmihalyi’s theoretical model as well.
A Review Study on the Introduction Strategy of RFID in University Hospitals
Authors:   The Korean Society of Culture and Convergence, Sung Haengnam , Shin Jaeik
Published: January 2023

The purpose of this study is to review related previous studies and to suggest strategies for introducing RFID to university hospitals. A university hospital's RFID introduction strategy should focus all its capabilities on system operation efficiency, medical service quality, and maximization of patient satisfaction. In addition, when a university hospital introduces an RFID system, an organizational culture that can share information on technical factors, organizational factors, environmental factors, economic factors, and human factors among management, medical staff, and employee will be required. A patient-oriented organizational culture will positively affect all aspects of the university hospital and contribute to the success of the RFID system.
The Effect of Nursing College Students' Problem-solving Ability and Nursing Professionalism on Clinical Competency in the COVID-19 Pandemic Era
Authors:   The Korean Society of Culture and Convergence, Moon Kilje , Cho Mooyong
Published: January 2023

The purpose of this study is to confirm the degree of problem-solving ability, nursing professionalism, and clinical competency of nursing students who conducted clinical practice and untact clinical practice in the COVID-19 situation, and to identify the influencing factors of clinical competency. As for the research method, a survey was conducted on 213 nursing students who had experienced clinical practice and untact clinical practice among senior nursing students at three universities in Seoul and Gyeonggi-do. The data was analyzed by t-test, ANOVA, Pearson correlation coefficient, and multiple regression using SPSS 21.0. The factors influencing clinical competency ability were problem-solving ability(β=.669, p=<.001), nursing professionalism(β=.166, p=.002), voluntary selection of nursing science(β=.092, p=.029), and the explanatory power was 64.0%.
Validation of the Adaptive Expertise Scale
Authors:   The Korean Society of Culture and Convergence, Jung Yunhee
Published: January 2023

The purpose of this study is to develop an adaptive expertise scale, a newly emerging expertise construct. To this end, data were collected for adults to analyze the reliability and validity of the adaptive expertise scale. As a result of the study, the developed adaptive expertise scale was confirmed to have construct validity, discrimination validity, convergence validity, criterion validity, and reliability. The adaptive expertise scale was a total of 10 items, and the sub-factors consisted of domain-specific skill, innovation skill, and metacognitive skill. Through this study, it is expected to expand the understanding of adaptive expertise and provide information for the development of adaptive expertise education programs.
Practical Plan for Remote Classes in Art and Culture Education Instructor Using Google Site Tools
Authors:   The Korean Society of Culture and Convergence, Lee Seonmi
Published: January 2023

The purpose of this paper is to discuss practical measures for remote classes in the history of culture and art education. To this end, as one of the useful methods for remote classes in the second-level cultural arts education course, we tried to find a class plan by giving an example of actively using 'Google Site Tool'. This study first explored art and culture education instructor and Google site tools. Then, based on the cases of remote classes in , the stages of 'preparation', 'benefit', 'practice', and 'utilization' were set. Using these steps, we devised a practical class plan that can promote interaction between learners and improve learning reality in remote classes using Google Site Tools. This study is meaningful in that it suggests the possibility of operating various activities such as solving project tasks in distance classes in the art and culture education instructor and a useful method for students to reach their learning goals with interest.
The Reality and Value of Home Care in Nursing Records “I Eat with My Mom Every Day”
Authors:   The Korean Society of Culture and Convergence, Jeong Siyoul
Published: January 2023

Analyzing the text of “I eat with my mother every day”, the autobiographical records of an elderly man in his 60’s who took care of his mother in her 90’s with dementia for nine years in an apartment space, this researcher considers the beginning and difficulties of home care, psychological conflicts experienced in the process of caring, and the moments of mental maturity that occurred every now and then in the dragging time. In the first chapter of the main body, this study has found why the writer began home care and the fact that home care is such a difficult process that can be even said to a state of humanity way beyond the path of filial piety. In the next chapter, this study examines the processes in which respect for the mother disappears and only hatred remains within the conflict with her that has become a routine and the author’s cry coming from the inside. In the last chapter, this researcher looks into the process in which the author’s ego continues to mature within conflicts between the practice of filial piety and realistic problems. This study will serve as a reference for individuals in situations where they have to take care of their families.
Moderation Effect of the Size of the Residential Area on the Relationship Between Older Adults’ Depressive Symptoms and Cognition
Authors:   The Korean Society of Culture and Convergence, Han Junsik , Lee Kyuho
Published: January 2023

The decline in cognitive function is considered a natural phenomenon with aging. However, when it is severe, it can bring about difficulties in social relationships and activities as well as negatively affects, low self-esteem, isolation, and depression. This study examines the relationship between older adults’ depressive symptoms and cognitive function as well as the moderating effect of city size. To this end, the 7th wave of the Korean Longitudinal Study of Aging(KLoSA) was analyzed. The results confirmed the moderation effect of city size in the relationship between older adults’ depression and cognitive functioning. The participants living in small- or medium-sized cities, as compared to the participants living in large cities, showed a more rapid decrease in cognitive functioning when they had more depressive symptoms. This study is of practical significance in that it examined urban and regional effects on the relationship between older adults’ depressive symptoms and cognitive functioning to which has been paid relatively little attention. The current study also provides support in revitalizing related studies and devising policies and programs for older adults.
A Study on the Variation Pattern and Meaning of the 'Chunhyang' Narrative in the Webtoon Based on Cl
Authors:   The Korean Society of Culture and Convergence, Lee Chaeyoung
Published: January 2023

This paper attempted to analyze the characteristics and patterns of “Chunhyangjeon,” a representative example of classics that are recreated in various ways, when they are recreated in the webtoon genre. In other words, the purpose of this study is to examine the variation pattern of the webtoon “Gwanghallu Romance” based on the “Chunhyang” narrative, explore the characteristics found in this variation pattern, and what these characteristic points mean in the re-creation of classical narratives. As a result of the study, the variation of the “Chunhyang” narrative in “Gwanghulu Romance” is divided into three characteristics.
A Critical Review on the Researches of Science and Engineering Students Writing: Transition from Specialized Writing to Integrated Basic Writing
Authors:   The Korean Society of Culture and Convergence, Choi Jun Ho
Published: January 2023

The purpose of this paper is to critically review the existing researches on science and engineering writing, focusing on the necessity of 'specialized science and engineering freshman writing', and to arouse the need for 'more in-depth research and corresponding learning' through it. The order of writing for this purpose is as follows. First, existing researches on science and engineering writing will be critically reviewed, focusing on specialized freshmen writing. Through this, if the research on writing for freshmen in science and engineering is toward academic writing, based on the consideration of the basics of academic writing in general or the consideration of the contact point with academic writing in the humanities and social sciences, it will be argued that it is needed to 'break away from the obsession with instrumental writing'. At the end, three suggestions related to the research and learning of writing for freshmen in science and engineering will be presented.
Differences in Education and Sports Activities Expectations of Korean and Chinese Parents for Athletes’ Children According to Environmental Characteristics of Student Athletes
Authors:   The Korean Society of Culture and Convergence, Kong Mengyuan , Kim Youngmee
Published: January 2023

The purpose of this study is to investigate the differences in education and sports activities expectations of Korean and Chinese parents according to the environmental characteristics of student-athletes. A total of 560 parents of student athletes were sampled from middle & high schools located in Korea and China. As a results, first, There are differences in academic expectations according to the characteristics of parents. Chinese parents had higher academic and sports expectations than Korean parents. High-income Chinese parents have higher expectations for school athletic performance, school sports activities, and sports club activities than low-income Korean parents. Second, Korean parents most expect their children of student athletes to become national athletes, while Chinese parents most expect their children to become general sports leaders after entering a sports department. Third, both Korea and China have higher athletic expectations for male athletes than female athletes, and higher expectations for children who play individual and interpersonal events rather than team events.
ПЛЮРАЛІЗМ РОЗУМІННЯ ЮРИДИЧНОЇ ПРИРОДИ ОСВІТНЬОГО ПРАВА
Authors: Янчук Н. Д.
Published: January 2023

У статті порушено питання про юридичну природу освітнього права. На сучасному етапі освітнє право є галуззю законодавства, яка найбільш активно розвивається, що спричиняє нові виклики для правової науки і практики. У відповідь на ці виклики формується освітнє право, яке потребує правового аналізу як із позиції теорії, так і з практичної точки зору. У вітчизняній юридичній літературі не сформовано єдиного підходу до розуміння правової природи освітнього права, а тому виникає необхідність дослідити його як нове явище. У статті акцентовано увагу на тому, що трансформація поглядів відносно природи освітнього права пройшла тривалий шлях від повного його несприйняття, коли вважалось що це лише підгалузь у рамкам адміністративного права, до спроб обґрунтування освітнього права як самостійної галузі права. Здійснено аналіз різних підходів щодо визначення юридичної природи освітнього права, а саме як: підгалузі адміністративного права; комплексної галузі права; нормативно-правового масиву; самостійного напрямку наукових досліджень; навчальної дисципліни; спеціальної частини інформаційного права. Особливу увагу приділено висвітленню сильних і слабких позицій представників різних напрямків в обґрунтуванні статусу освітнього права. Акцентовано на тому, що жоден із прихильників виокремлення освітнього права як самостійної галузі права, не довів та не показав, чому питання правового регулювання освітніх відносин варто розглядати поза адміністративним правом. Наголошено на необхідності включення до навчального плану окремого курсу «Освітнє право» в педагогічному секторі освіти та при навчанні в аспірантурі. При тому мова не йде про формування уніфікованого підходу до викладання навчальної дисципліни «Освітнє право». Предмет та система навчальної дисципліни має визначатися цільовою аудиторією, а також сучасними тенденціями розвитку освіти.
ПОРУШЕННЯ ЗАКОНІВ І ЗВИЧАЇВ ВІЙНИ: БЕЗПОСЕРЕДНІ ОБ’ЄКТИ, ПРЕДМЕТИ ТА ПОТЕРПІЛІ ВІД ЗЛОЧИНУ. ЗАГАЛЬНІ ПОЛОЖЕННЯ «JUS IN BELLO»
Authors: Вознюк А. А. , Жук І. В.
Published: January 2023

У статті розкрито суспільну небезпеку, безпосередній основний та безпосередні додаткові обов’язкові об’єкти, предмет злочинів, передбачених ст. 438 КК, а також потерпілих від них. У межах загальних положень міжнародного гуманітарного права («jus in bello») розглянуто його джерела – міжнародні договори та правові звичаї, під час аналізу яких звернено увагу на Женевські конвенції, Додаткові протоколи до них, Римський статут Міжнародного кримінального суду, застереження Мартенса. Досліджено проблеми тлумачення термінів «міжнародний збройний конфлікт» і «збройний конфлікт неміжнародного характеру». З-поміж іншого, аргументовано, що обов’язковими ознаками окремих проявів порушення законів і звичаїв війни є наявність предметів цих злочинів та потерпілих від них. Незважаючи на те, що в диспозиції ст. 438 КК згадується лише про національні цінності (як предмет злочину) та військовополонених і цивільне населення (як потерпілих від злочину), види інших предметів воєнних деліктів і потерпілих можна встановити на підставі тлумачення положень ст. 438 КК та відповідних норм МГП. Перелік потерпілих слід визначати залежно від виду збройного конфлікту. Встановлено, що застосування терміна «національні цінності» для позначення предмета злочину, передбаченого ст. 438 КК, забезпечує більш широкий кримінально-правовий захист важливих об’єктів на території України, порівняно з терміном «культурні цінності», кримінально-правова охорона яких забезпечується нормами МГП. Перспективною в контексті подальшої науково-теоретичної розробки є пропозиція диференціювати кримінальну відповідальність за порушення законів і звичаїв війни шляхом виокремлення в самостійних частинах статті посягань на об’єкти, що потребують спеціального (посиленого) захисту. Акцентовано, що сфера дії норм МГП обмежується часом (а можливо, й обстановкою) збройного конфлікту міжнародного або неміжнародного характеру. При всьому положення національного регулятивного законодавства щодо визначень збройних конфліктів не збігаються з відповідними положеннями МГП.
Microbial control during the incubation of rainbow trout (Oncorhynchus mykiss) eggs exposed to humic acid
Authors: Chiasson Marcia , Kirk Michael , Huyben David
Published: January 2023

Introduction

Cultured fish species are increasingly exposed to fungi and bacteria in the rearing environment, often causing disease and mortality causing aquaculture producers to rely on the use of chemical therapeutants which may have negative consequences for both human and environmental health. This study investigated the effect of humic acid as a treatment to reduce fungal and bacterial infections to increase survival during the incubation of rainbow trout (Oncorhynchus mykiss) eggs.

Methods

Humic acid, an aqueous extract of oxidized lignite was added to water entering both stacked tray and jar type incubators at a dosage rate of 5 mg/L from fertilization until hatching.

Results

The water treatment eliminated observable fungus and significantly improved survival until hatching in the treated incubator trays (77.2%) compared to the untreated controls (55.5%) (p ≤ 0.001). Egg survival was not improved in the incubator jars. The humic acid reduced bacterial diversity, but only in the stacked tray incubators and altered bacterial composition of the water after 20 days of treatment.

Discussion

The treatment increased the bacterial abundance of Burkholderiales, positively associated with healthy fish eggs and decreased the abundance of Flavobacterium and Aeromonas, known fish pathogens. These findings support the topical treatment of humic acid as a potential alternative treatment to prevent fungal infections and reduce mortality during incubation of rainbow trout eggs.
Biomass-specific rates as key performance indicators: A nitrogen balancing method for biofilm-based electrochemical conversion
Authors: Winkelhorst Marijn , Cabau-Peinado Oriol , Straathof Adrie J.J. , Jourdin Ludovic
Published: January 2023

Microbial electrochemical technologies (METs) employ microorganisms utilizing solid-state electrodes as either electron sink or electron source, such as in microbial electrosynthesis (MES). METs reaction rate is traditionally normalized to the electrode dimensions or to the electrolyte volume, but should also be normalized to biomass amount present in the system at any given time. In biofilm-based systems, a major challenge is to determine the biomass amount in a non-destructive manner, especially in systems operated in continuous mode and using 3D electrodes. We developed a simple method using a nitrogen balance and optical density to determine the amount of microorganisms in biofilm and in suspension at any given time. For four MES reactors converting CO2 to carboxylates, >99% of the biomass was present as biofilm after 69 days of reactor operation. After a lag phase, the biomass-specific growth rate had increased to 0.12–0.16 days−1. After 100 days of operation, growth became insignificant. Biomass-specific production rates of carboxylates varied between 0.08–0.37 molC molX−1d−1. Using biomass-specific rates, one can more effectively assess the performance of MES, identify its limitations, and compare it to other fermentation technologies.
Novel resorbable bone wax containing β-TCP and starch microspheres for accelerating bone hemostasis and promoting regeneration
Authors: Duan Qiangqiang , Liu Huiling , Zheng Lixia , Cai Daozhang , Huang Guangxin , Liu Yu , Guo Rui
Published: January 2023

Traditional non-resorbable bone wax has been used in clinical surgery for more than 100 years. However, residual bone wax has been proven to cause numerous complications. In this study, a novel resorbable bone wax was designed to overcome the disadvantages of traditional non-resorbable bone wax. Alkylene oxide copolymers were used as the main component of resorbable bone wax; additionally, β-tricalcium phosphate and starch microspheres were added to enhance bone regeneration and hemostatic ability. This novel resorbable bone wax has a high potential for clinical translation and is expected to be developed as a substitute for traditional bone wax.
Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapy
Authors: Sarmah Hemanta , Sawada Anri , Hwang Youngmin , Miura Akihiro , Shimamura Yuko , Tanaka Junichi , Yamada Kazuhiko , Mori Munemasa
Published: January 2023

Millions of people suffer from end-stage refractory diseases. The ideal treatment option for terminally ill patients is organ transplantation. However, donor organs are in absolute shortage, and sadly, most patients die while waiting for a donor organ. To date, no technology has achieved long-term sustainable patient-derived organ generation. In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology.
Intercellular communication in the cumulus–oocyte complex during folliculogenesis: A review
Authors: Xie Jun , Xu Xiao , Liu Suying
Published: January 2023

During folliculogenesis, the oocyte and surrounding cumulus cells form an ensemble called the cumulus-oocyte complex (COC). Due to their interdependence, research on the COC has been a hot issue in the past few decades. A growing body of literature has revealed that intercellular communication is critical in determining oocyte quality and ovulation. This review provides an update on the current knowledge of COC intercellular communication, morphology, and functions. Transzonal projections (TZPs) and gap junctions are the most described structures of the COC. They provide basic metabolic and nutrient support, and abundant molecules for signaling pathways and regulations. Oocyte-secreted factors (OSFs) such as growth differentiation factor 9 and bone morphogenetic protein 15 have been linked with follicular homeostasis, suggesting that the communications are bidirectional. Using advanced techniques, new evidence has highlighted the existence of other structures that participate in intercellular communication. Extracellular vesicles can carry transcripts and signaling molecules. Microvilli on the oocyte can induce the formation of TZPs and secrete OSFs. Cell membrane fusion between the oocyte and cumulus cells can lead to sharing of cytoplasm, in a way making the COC a true whole. These findings give us new insights into related reproductive diseases like polycystic ovary syndrome and primary ovarian insufficiency and how to improve the outcomes of assisted reproduction.
Outdoor recreation and the private forest owner: Place attachment, social values, and public access
Authors: Johnsson Frida , Beery Thomas
Published: January 2023

Introduction

The Swedish National Forest Program emphasizes that the forest can be more multifunctional where the values created by human experiences of the forest, i.e., social values, can be used for tourism and outdoor recreation, leading to rural development and sustainable growth. To develop multifunctional forests in this respect, private forest owners' perspectives on development are critically important. For example, the place attachment of the private forest owners affects how they manage their forests. Therefore, it is crucial to consider private forest owners' perspectives when planning land use.

Method

The study area is a region in southwest Sweden (Hallandsås) designated as a national interest area for outdoor recreation. There is interest in expanding and developing nature-based tourism, including trail systems, based on the perception of the areas as having great outdoor recreation value. This article aims to present findings from a study that investigated the potential for outdoor recreation development in the forests of Hallandsås. A questionnaire was sent out to private forest owners, which contained questions about social values, perspectives on the Swedish right of public access, development of outdoor recreation, and place attachment.

Results

The results showed that private forest owners considered health, well-being, and a good living environment the most important social values of their forested lands. The identity and cultural heritage value of private forest lands and the value of working on the land were the second and third most highly identified forest social values. Outdoor recreation was not identified as a top forest social value.

Discussion

The analysis identified seven key factors that must be considered with outdoor recreation development, given concerns and the importance of other forest social values. Careful consideration of these factors and their interactions can provide a path for outdoor recreation development that is respectful to people and places. This consideration is at the core of landscape protection and management as interpreted by the European Landscape Convention. Forest owners' social values are a critical part of landscape quality objectives, along with planning that links public aspirations with landscape character.
Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy
Authors: Murakata Yoshiko , Yamagami Fumi , Murakoshi Nobuyuki , Xu DongZhu , Song Zhonghu , Li Siqi , Okabe Yuta , Aonuma Kazuhiro , Yuan ZiXun , Mori Haruka , Aonuma Kazutaka , Tajiri Kazuko , Ieda Masaki
Published: January 2023

Background

There is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory atrial cardiomyopathy may contribute to the development of AF, the arrhythmogenic remodeling caused by atrial inflammation has not been elucidated in detail. Herein, we examined electrical, structural, and autonomic changes in the atria in a mouse model of autoimmune myocarditis.

Methods

BALB/c mice were immunized with cardiac myosin peptide (MyHC-α614–629) conjugated with complete Freund’s adjuvant on days 0 and 7. Susceptibility to AF was assessed using right-atrial burst pacing.

Results

The mice immunized with MyHC-α614–629 showed an inflammatory atrial cardiomyopathy phenotype, with enlarged atria; a high degree of inflammatory cell infiltration primarily consisting of CD4+ T cells, CD8+ T cells, Ly6GlowCD11b+ macrophages, and CD11c+ dendritic cells; and severe interstitial fibrosis with collagen deposition. These mice demonstrated significantly enhanced susceptibility to AF, as indicated by their increased AF induction rate and duration. In addition, the expression of potassium channels (Kcnh2, Kcnd3, and Kcnj2) and calcium handling-associated genes (Cacna1c, Camk2, Ryr2, and Atp2a2) was downregulated. Connexin 40 expression was significantly downregulated, leading to frequent lateralization to the inflamed atrium. Sympathetic and parasympathetic innervation and neurotrophin expression (nerve growth factor and brain-derived neurotrophic factor) were upregulated in the inflamed atria.

Conclusion

Inflammatory atrial cardiomyopathy promotes susceptibility to AF via arrhythmogenic electrical, structural, and autonomic remodeling of the atria.
Risk factors from Framingham risk score for anthracyclines cardiotoxicity in breast cancer: A systematic review and meta-analysis
Authors: Jin Hao , Xu Jianfeng , Sui Zheng , Wang Lili
Published: January 2023

Background

Framingham risk score (FRS) is an effective tool for evaluating the 10-year risk of cardiovascular diseases. However, the sensitivity of FRS for anthracycline-induced cardiotoxicity is unclear. This meta-analysis aims to evaluate the correlation between risk factors (hypertension, hyperlipidemia, diabetes, smoking, and obesity) in FRS and anthracycline-induced cardiotoxicity in breast cancer.

Methods

We searched PubMed, EMBASE, and Cochrane Library for studies published from inception to January 2022 which reported cardiotoxicity due to anthracycline. Cardiotoxicity defined as any cardiac events were used as the primary endpoint. A total of 33 studies involving 55,708 breast cancer patients treated with anthracyclines were included in this meta-analysis.

Results

At least one risk factor was identified at baseline for the 55,708 breast cancer patients treated with anthracycline. Hypertension [I2 = 45%, Fixed, RR (95% CI) = 1.40 (1.22, 1.60), p < 0.00001], hyperlipidemia [I2 = 0%, Fixed, RR (95% CI): 1.35 (1.12, 1.62), p = 0.002], diabetes [I2 = 0%, Fixed, RR (95% CI): 1.29 (1.05, 1.57), p = 0.01], and obesity [I2 = 0%, Fixed, RR (95% CI): 1.32 (1.05, 1.67), p = 0.02] were associated with increased risks of cardiac events. In addition, smoking was also associated with reduced left ventricular ejection fraction (LVEF) during anthracycline chemotherapy [I2 = 0%, Fixed, OR (95% CI): 1.91 (1.24, 2.95), p = 0.003] in studies that recorded only the odds ratio (OR).

Conclusion

Hypertension, hyperlipidemia, diabetes, smoking, and obesity are associated with increased risks of anthracycline-induced cardiotoxicity. Therefore, corresponding measures should be used to manage cardiovascular risk factors in breast cancer during and after anthracycline treatment.
Insights into pelvic venous disorders
Authors: Rezaei-Kalantari Kiara , Fahrni Guillaume , Rotzinger David C. , Qanadli Salah D.
Published: January 2023

Pelvic venous disorders (PeVD), sometimes referred to as pelvic congestion syndrome (PCS), widely impact affected patients–mainly young women’s quality of life, causing puzzling, uncomfortable symptoms sometimes requiring months or years to get an explanation, while simply remaining undiagnosed in other cases. Because pelvic pain is a non-specific symptom, an appropriate diagnosis requires a careful patient workup, including a correlation between history and non-invasive imaging. Invasive imaging is frequently required to confirm the diagnosis and plan treatment. Current therapeutic approaches principally rely on minimally invasive techniques delivered through endovascular access. However, while comprehensive descriptive classifications such as the symptoms-varices-pathophysiology (SVP) classification exist, universally accepted guidelines regarding therapy to apply for each SVP category are still lacking. This review strongly focuses on PeVD imaging and discusses available therapeutic approaches with regard to pathophysiological mechanisms. It proposes a new classification scheme assisting clinical decision-making about endovascular management to help standardize the link between imaging findings and treatment.
Impact of extreme debris flow-induced paleodamming events on the sedimentological evolution of the middle Yarlung Tsangpo River reaches since the late Pleistocene, Tibet
Authors: Wang Huiying , Wang Ping , Hu Gang , Yuan Renmao , Ge Yukui , Xu Bo , Shi Lingfan
Published: January 2023

As extreme surface processes, long-term river damming and outburst events can impact sediment supply and transportation in valleys and therefore significantly change the landscape. Lacustrine sediments were identified in the wide Xigaze Valley, in the middle reaches of the Yarlung Tsangpo River in Tibet, an area which has been considered to have been a paleodammed lake. However, the evolutionary process and damming mechanisms associated with this paleolake, and any subsequent impact on sedimentation within the valley, remain unclear. Here, we present a detailed geomorphological and sedimentary analysis of the proposed paleolake area, based on a study of a prominent valley fill found along a section of the Yarlung Tsangpo River and its tributary that flows into it from the south, the Menchu River. This section stretches from Xigaze to Dazhuka. Sedimentary facies analysis of two stratigraphic sections in Renbu Town showed that at least two paleolakes caused by debris flow related to glaciers developed in the Xigaze Valley and that the paleodam was located near the outlet of the Dazhuka Gorge. Chronological constraints suggest that the first damming event occurred between ∼48.6 and 33.7 ka in Marine Isotope Stage (MIS) 3 and had a minimum lake surface elevation of ∼3,820 m. The second damming occurred between ∼24.3 and 12.7 ka during the Last Glacial Maximum (LGM), producing a lake surface elevation of at least ∼3,760 m. During the development of the paleolakes in the Xigaze Valley, several small-scale damming and outburst events happened in the upper and middle reaches of the Menchu River, resulting in fluviolacustrine and outburst flood sediments accumulating in the main stream of the Yarlung Tsangpo River and forming thick-fill terraces. We presumed that the paleolakes in the middle reaches of the Yarlung Tsangpo River gradually drained as a result of continuous overflow undercutting instead of outburst flood events, thereby allowing fluvial aggradation of the upper reaches of the paleodam.
Warming increases the relative change in the turnover rate of decadally cycling soil carbon in microbial biomass carbon and soil respiration
Authors: Liu Dan , Zhang Wenling , Xiong Chunmei , Nie Qingyu
Published: January 2023

Decadally cycling soil carbon (dSOC) is the main component of the terrestrial soil carbon (C) pool. The response of dSOC to warming largely determines the feedback between climate warming and the C cycle. However, there is a lack of investigations about the effect of warming on the relative change in turnover rate (RCT) of dSOC and annually cycling SOC (aSOC) in dissolved organic carbon (DOC), microbial biomass carbon (MBC) and CO2. We clarified this issue by incubating two C3-C4 vegetation switch soils (23 years switch, HA soil and 55 years switch, GG soil) at 20°C and 30°C in the recently improved continuous airflow CO2 trapping system for 1 year. Warming increased the contribution of dSOC (C3-C) by 21℅ (soil HA) and 8℅ (soil GG) in MBC, and 38℅ (soil HA) and 15℅ (soil GG) in CO2, while only 2%–3℅ increase in DOC at the final stage of the incubation. Furthermore, warming increased the RCT in MBC and CO2 by 5.3- and 4.1-fold, respectively, but had no significant influence on the RCT in DOC, indicating that soil microbes may be an important engine to accelerate dSOC-derived CO2 emission in a warming world.
Study on the influence of confining pressure and unloading damage on the bursting liability characteristics of coal
Authors: Du Taotao , Pan Junfeng , Xia Yongxue , Sun Ruda
Published: January 2023

The research on the bursting liability of coal under confining pressure and unloading damage is critical in creating prevention mechanisms for coal mass rock bursts in deep underground mines. Cyclic loading and unloading tests of variable stress with a lower limit were performed under multistage confining pressure and different amplitude unloading to explore their influence on the impact tendency of the coal bodies. Meanwhile, the characteristic parameter analysis of acoustic emissions was used to evaluate the failure. The results revealed that the accumulated number and energy of acoustic emission events gradually decreased with increasing the confining pressure. The coal specimen became denser, and the failure mode gradually transitioned from brittle to ductile. With the increase in unloading amplitude, the cumulative number of acoustic emission events in the coal specimens decreases, the damage degree to the coal body increases, the peak load decreases, and the failure mode transitions from ductile to brittle. The increase in confining pressure results in an increase in the input energy and the elastic strain energy, while the increase in the unloading range of the coal body leads to a decrease in the input energy and elastic strain energy. In addition, after the confining pressures of 3 MPa, 6 MPa, and 9 MPa, the residual elastic energy index of the coal specimens increases by 21.76%, 42.92%, and 71.69%, respectively, compared with the room pressure conditions. The residual elastic energy index decreases by 21.11% and 55.38% for the unloading amplitude of 3 MPa and 6 MPa, respectively, compared with the unloaded coal specimen, indicating that the impact tendency of the coal body is enhanced by the confining pressure conditions.
Coal measure energy production and the reservoir space utilization in China under carbon neutral target
Authors: Chen Run , Bao Yunxia , Lv Fengrong , Chen Fu , Hu Kunpeng , Zhang Yajun
Published: January 2023

Coal measure energy production and reservoir space utilization are both important for energy security and can assist in achieving carbon neutrality. Coal measure energy production and reservoir utilization are therefore of scientific significance. This study focuses on the security of coal supply by discussing the possible technical approaches of combining low-carbon mining of coal measure resources and coal reservoir space utilization. Our study found that 1) the integration of underground coal gasification and carbon capture and sequestration (UCG-CCS) is an effective technology to improve energy efficiency and achieve the carbon neutral target in China; 2) CO2-enhanced coalbed methane (CO2-ECBM) recovery is an important way to reduce CO2 emissions during coalbed methane recovery; and 3) the integrated technology of solid waste filling (WF), coal bioconversion (CB), gas production (GP), and CO2 capture and sequestration (CCS) in coal goafs and abandoned coal mines can improve the energy production efficiency and reservoir space utilization and reduce geological disasters due to surface subsidence. These integrated technologies will become increasingly important for coal measure energy production and efficient reservoir space utilization as they will provide scientific theory and technical support to achieve carbon neutrality.
Levy flight-improved grey wolf optimizer algorithm-based support vector regression model for dam deformation prediction
Authors: He Peng , Wu Wenjing
Published: January 2023

Considering the strong non-linear time-varying behavior of dam deformation, a novel prediction model, called Levy flight-based grey wolf optimizer optimized support vector regression (LGWO-SVR), is proposed to forecast the displacements of hydropower dams. In the proposed model, the support vector regression is used to create the prediction model, whereas the Levy flight-based grey wolf optimizer algorithm is employed to search the penalty and kernel parameters for SVR. In this work, a multiple-arch dam was selected as a case study. To validate the proposed model, the predicted results of the model are compared with those derived from Grid Search algorithm, Particle Swarm Optimization, Grey Wolf Optimizer algorithm, and Genetic algorithm. The results indicate that the LGWO-SVR model performs well in the accuracy, stability, and rate of prediction. Therefore, LGWO-SVR model is suitable for dam engineering application.
C20-C21-C23 tricyclic terpanes abundance patterns: Origin and application to depositional environment identification
Authors: Wang Aiguo , Li Chunyu , Li Long , Pu Renhai , Yang Zeguang , Zhu Nan , Guo Kai
Published: January 2023

Reconstruction of paleo-depositional environments in a sedimentary basin is often obstructed by the absence of typical environmental indicators in sedimentary rocks. Here, we propose a biomarker method using C20-C21-C23 tricyclic terpanes (TTs) as a tracer, which is simple in analysis but robust to provide reliable and detailed environmental information. Based on the analysis of 271 C20-C21-C23TT data from 32 basins in 18 countries, we observed a relationship between C20-C21-C23TT abundance patterns and depositional environments. This relationship was attributed to the control of depositional environments on the input proportions of plankton and terrigenous plants, which act as two end-member precursors for the TTs in a depositional system. The various mixing proportions between these two end-members result in different C20-C21-C23TT abundance patterns associated with different depositional environments, e.g., C20>C21>C23TT in river-lake transitional, C20<C21<C23TT in marine or saline lacustrine environments, C20C23TT in freshwater lacustrine and C20>C21<C23TT in marine-continental transitional environments. In addition, the C23/C21TT ratio increases with elevated salinity of depositional water, and the C21/C20TT ratio increases with increasing water depths. Based on these observations, a discrimination diagram using C23/C21TT vs. C21/C20TT was developed for environmental identification. The validity of this C20-C21-C23TT biomarker method is well demonstrated by the rock samples with typical environmental indicators. This method is applicable in a broad spectrum of rocks and in maturities up to 2.4%Ro. Its strength was shown by a case study of a complex depositional system in the East China Sea Basin, which has been strongly affected by eustasy.
Local symptoms of Hashimoto’s thyroiditis: A systematic review
Authors: Yuan Jiaojiao , Qi Shuo , Zhang Xufan , Lai Hezheng , Li Xinyi , Xiaoheng Chen , Li Zhe , Yao Simiao , Ding Zhiguo
Published: January 2023

Objective

Hashimoto’s thyroiditis (HT) is the most common type of thyroid disease and can cause many different manifestations. The local symptoms of HT are an under-studied area of research. Therefore, the purpose of this study was to investigate the local symptoms of HT and their prevalence.

Methods

A systematic review was performed to find articles in PubMed that discuss the local symptoms of HT. Relevant vocabulary terms and key terms included: autoimmune thyroid disease (AITD), hyperthyroidism, hypothyroidism, neck, throat, pharynx, airway, esophagus, breathe, swallow, globus, sleep apnea, symptoms, and quality of life. Two investigators independently screened the eligible studies.

Results

A total of 54 articles fulfilled the inclusion criteria. Of these, 25 were clinical studies, 24 were case reports, and five were reviews. These clinical studies and case reports included a total of 2660 HT patients. There were eight local symptoms related to HT: neck pain (0.02%~16%), voice changes (7%~30%), throat discomfort (20%~43.7%), shortness of breath (28%~50%), dysphagia (29%), goiter-related symptoms (69.44%), sleep apnea, and generally defined compressive symptoms. Due to the use of different outcome measures among all the studies, a meta-analysis of the data could not be performed.

Conclusion

Goiter symptoms, which are an item on the ThyPRO scales, are the most frequent local symptoms in HT patients, and include neck pain, voice changes, throat discomfort, and dysphagia. These local symptoms should be identified in the clinic and included in the early diagnosis and management of HT, as well as evaluated further to understand their relevance in the pathogenesis of HT.
Emerging role of UFMylation in secretory cells involved in the endocrine system by maintaining ER proteostasis
Authors: Cheng Yun , Niu Zikang , Cai Yafei , Zhang Wei
Published: January 2023

Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like molecule (UBL) discovered almost two decades ago, but our knowledge about the cellular and molecular mechanisms of this novel protein post-translational modification is still very fragmentary. In this review, we first summarize the core enzymes and factors involved in the UFMylation cascade, which, similar to ubiquitin, is consecutively catalyzed by UFM1-activating enzyme 5 (UBA5), UFM1-conjugating enzyme 1 (UFC1) and UFM1-specific ligase 1 (UFL1). Inspired by the substantial implications of UFM1 machinery in the secretory pathway, we next concentrate on the puzzling role of UFMylation in maintaining ER protein homeostasis, intending to illustrate the underlying mechanisms and future perspectives. At last, given a robust ER network is a hallmark of healthy endocrine secretory cells, we emphasize the function of UFM1 modification in physiology and pathology in the context of endocrine glands pancreas and female ovaries, aiming to provide precise insight into other internal glands of the endocrine system.
The effect of Kuntai capsule on ovarian function in cisplatin-induced premature ovarian insufficiency rats
Authors: Luo Suiyu , Ruan Xiangyan , Mueck Alfred O.
Published: January 2023

Objective

This study aims to evaluate the effect of Kuntai capsule on ovarian function in cisplatin-induced premature ovarian insufficiency rats and to explore the mechanism of Kuntai capsule on the ovarian function of rats.

Methods

Seventy-four female Sprague-Dawley rats were used for this study. Eight of the rats were randomly assigned to the Control group. The remaining sixty-six rats were utilized to establish the POI model via Cisplatin and then randomly divided into four groups: the model Control group, the Estradiol group, and groups treated with low and high doses of Kuntai capsule. For the 28-day administration, the Control and model Control groups were intragastrically administered with 2.0 mL of 0.9% sodium chloride daily, the Estradiol group with 2.0 mL of Estradiol suspension (0.2mg/kg/d), and the low dose Kuntai capsule group and the high dose Kuntai capsule group with 2.0 mL of Kuntai capsule suspension (0.6g/kg/d, 1.8g/kg/d, respectively). Sex hormone levels, estrous cycle, and ovarian coefficient of the five groups were compared, histological sections analyzed follicle counts, and the protein expressions of growth differentiation factor 9, light chain 3 A-II, and Beclin 1 in the ovarian tissue were detected by Western blotting.

Results

After the 28-day administration, the serum Estradiol and Follicle-Stimulating Hormone levels of the group treated with low dose of Kuntai capsule were not significantly different from the Control group, the serum anti-Müllerian Hormone level of the group treated with high dose of Kuntai capsule was significantly higher than the Estradiol group. The estrous cycle of the group treated with low dose of Kuntai capsule was significantly lower than the model Control group. Regarding ovarian coefficient, resting and growing follicles, growth differentiation factor 9, light chain 3 A-II, and Beclin 1 expression, both Kuntai capsule groups outperformed the model Control group with the statistical difference (P<0.05).

Conclusion

Kuntai capsule can improve the estrous cycle and ovarian coefficient of rats with premature ovarian insufficiency, maintain the number of resting and growing follicles, and up-regulate the protein expression of growth differentiation factor 9, light chain 3 A-II, and Beclin 1 of rats’ ovaries.