bluuebunny/crossref_metadata_2025 huggingface dataset:
Widening the Tent: Jewish Inclusivity, Antisemitism, and Recommendations for Action in Pediatric Psychology
Authors: Getzoff Testa Elizabeth , Becker Jamie A. , Brosbe Micah S. , Fiat Aria E. , Kaufman Caroline C. , Berger Carly , Fishbein Danielle , Gross Yael
Published: December 2024

Objective: Antisemitism is prejudice against, hostility toward, or hatred of Jews. This prejudice has negatively impacted pediatric psychology practitioners, learners, and patients, leading to increased fear and psychological harm. A group of Jewish-identifying pediatric psychologists and psychology learners assembled to outline antisemitism in the context of pediatric psychology practice, research, and training, provide a brief primer on Judaism and present actionable strategies to support Jewish colleagues, learners, and families. Method: The negative impacts of antisemitism within pediatric psychology are outlined, and a review of relevant literature invites practitioners and researchers of varying levels and disciplines of pediatric psychology to recognize and combat antisemitism. There are no human subjects; consent and institutional review board were not needed. Results: Antisemitic microaggressions and prejudice experienced and/or witnessed by authors are briefly described and synthesized, with four core themes emerging: overtly antisemitic behavior, tropes/stereotypes, erasure/invisibility, and silencing. Finally, recommendations for action using the antisemitism-adapted STYLE framework and the opportunity for inclusion of Judaism in diversity, equity, and inclusion work are provided. Conclusions: By promoting a better understanding of Judaism and the Jewish people, this article encourages increased consideration for Jewish identity and Jewish experience in pediatric psychology practice, research, and training.

Implications for Impact Statement

The current article highlights antisemitism, an underrecognized form of prejudice, and its impact on patients, families, learners, and colleagues within pediatric psychology settings. Additionally, the current article provides actionable recommendations for clinicians, educators, and researchers to address antisemitism and its impact in pediatric psychology. Recognizing the existence and consequences of antisemitism, and taking steps to address antisemitism, aligns with the field of pediatric psychology’s commitment to promoting diversity, tolerance, and ethical behavior.
On-demand zero-drag hydrodynamic cloaks resolve D'Alembert paradox in viscous potential flows
Authors: Yao Neng-Zhi , Wang Bin , Wang Hao , Wu Chen-Long , Shih Tien-Mo , Wang Xuesheng
Published: December 2024

The possibility of freely manipulating flow in accordance with humans will remain indispensable for breakthroughs in fields such as microfluidics, nanoengineering, and biomedicines, as well as for realizing zero-drag hydrodynamics, which is essential for alleviating the global energy crisis. However, persistent challenges arise from the D’Alembert paradox and the unresolved Navier-Stokes solutions, known as the Millennium Problem. These obstacles also complicate the development of hydrodynamic zero-drag cloaks across diverse Reynolds numbers. Our research introduces a paradigm for such cloaks, relying exclusively on isotropic and homogeneous viscosity. Through experimental and numerical validations, our cloaks exhibit zero-drag properties, effectively resolving the D’Alembert paradox in viscous potential flows. Moreover, they possess the capability to activate or deactivate hydrodynamic concealment at will. Our analysis emphasizes the critical role of vorticity manipulation in realizing cloaking effects and drag-reduction technology. Therefore, controlling vorticity emerges as a pivotal aspect for future active hydrodynamic zero-drag cloak designs. In conclusion, our study challenges the prevailing belief in the impossibility of zero drag, offering valuable insights into invisibility characteristics in fluid mechanics with implications for microfluidics, biofluidics demanding the drug release or biomolecules transportation accurately and timely, and hypervelocity technologies.
Further delineation of the SCAF4-associated neurodevelopmental disorder
Authors: Schmid Cosima M. , Gregor Anne , Ruiz Anna , Manso Bazús Carmen , Herman Isabella , Ammouri Farah , Kotzaeridou Urania , McNiven Vanda , Dupuis Lucie , Steindl Katharina , Begemann Anaïs , Rauch Anita , Suter Aude-Annick , Isidor Bertrand , Mercier Sandra , Nizon Mathilde , Cogné Benjamin , Deb Wallid , Besnard Thomas , Haack Tobias B. , Falb Ruth J. , Müller Amelie J. , Linden Tobias , Haldeman-Englert Chad R. , Ockeloen Charlotte W. , Mattioli Francesca , Reymond Alexandre , Ibrahim Nazia , Naz Shagufta , Lacaze Elodie , Bassetti Jennifer A. , Hoefele Julia , Brunet Theresa , Riedhammer Korbinian M. , Elloumi Houda Z. , Person Richard , Zou Fanggeng , Kahle Juliette J. , Cremer Kirsten , Schmidt Axel , Delrue Marie-Ange , Almeida Pedro M. , Ramos Fabiana , Srivastava Siddharth , Quinlan Aisling , Robertson Stephen , Manka Eva , Kuechler Alma , Spranger Stephanie , Nowaczyk Malgorzata J. M. , Elshafie Reem M. , Alsharhan Hind , Hillman Paul R. , Dunnington Leslie A. , Braakman Hilde M. H. , McKee Shane , Moresco Angelica , Ignat Andrea-Diana , Newbury-Ecob Ruth , Banneau Guillaume , Patat Olivier , Kuerbitz Jeffrey , Rzucidlo Susan , Sell Susan S. , Gordon Patricia , Schuhmann Sarah , Reis André , Halleb Yosra , Stoeva Radka , Keren Boris , Al Masseri Zainab , Tümer Zeynep , Hammer-Hansen Sophia , Krüger Sølyst Sofus , Steigerwald Connolly G. , Abreu Nicolas J. , Faust Helene , Müller-Nedebock Amica , Tran Mau-Them Frédéric , Sticht Heinrich , Zweier Christiane
Published: December 2024

While mostly de novo truncating variants in SCAF4 were recently identified in 18 individuals with variable neurodevelopmental phenotypes, knowledge on the molecular and clinical spectrum is still limited. We assembled data on 50 novel individuals with SCAF4 variants ascertained via GeneMatcher and personal communication. With detailed evaluation of clinical data, in silico predictions and structural modeling, we further characterized the molecular and clinical spectrum of the autosomal dominant SCAF4-associated neurodevelopmental disorder. The molecular spectrum comprises 25 truncating, eight splice-site and five missense variants. While all other truncating variants were classified as pathogenic/likely pathogenic, significance of one C-terminal truncating variant, one splice-site variant and the missense variants remained unclear. Three missense variants in the CTD-interacting domain of SCAF4 were predicted to destabilize the domain. Twenty-three variants occurred de novo, and variants were inherited in 13 cases. Frequent clinical findings were mild developmental delay with speech impairment, seizures, and skeletal abnormalities such as clubfoot, scoliosis or hip dysplasia. Cognitive abilities ranged from normal IQ to severe intellectual disability (ID), with borderline to mild ID in the majority of individuals. Our study confirms the role of SCAF4 variants in neurodevelopmental disorders and further delineates the associated clinical phenotype.
Realizing the potential of mobile interventions for education
Authors: Breitwieser Jasmin , Neubauer Andreas B. , Schmiedek Florian , Brod Garvin
Published: December 2024

Mobile devices are ubiquitous, but their potential for adaptive educational interventions remains largely untapped. We identify three key promises of mobile interventions for educational research and practice: 1) intervening when it is most beneficial (i.e., “just-in-time adaptivity”), 2) estimating causal effects of interventions in ecologically valid settings, 3) considering the impact of context on the effectiveness of interventions. We discuss the challenges and next steps to advance this field.
Historical changes in the Causal Effect Networks of compound hot and dry extremes in central Europe
Authors: Tian Yinglin , Giaquinto Domenico , Di Capua Giorgia , Claassen Judith N. , Ali Javed , Li Hao , De Michele Carlo
Published: December 2024

Changes in hot and dry extremes in central Europe have been attributed to atmospheric circulation anomalies and land-atmosphere interactions. However, the strength of the underlying causal links and their historical trends have not been quantified. Here, we use Causal Effect Networks (based on the Peter and Clark momentary conditional independence algorithm) and show that hot extreme events in central Europe are driven primarily by anomalous atmospheric patterns and soil water deficiency. Dry extreme events are mainly induced by anomalous atmospheric patterns and soil moisture memory, and only marginally by temperature changes. We find that in the period 1979–2020, the influence of dry soil on temperature has been amplified by 67% during compound hot and dry extremes, while the impact of atmospheric drivers on soil moisture has intensified by 50% (36%) during compound (single) extremes. This work highlights the strengthened causal links of compound hot and dry extremes with their underlying drivers under global warming, which can lead to non-linear interactions and increase adaptation challenges.
Intrinsically photosensitive polyimide photoresist and its double crosslinking mechanism
Authors: Yang Peng , Yu Haiping , Zhu Yuting , Liu Xiaonuo , Liu Pin , Wang Xu , Tang Bo
Published: December 2024

A new photoinitiator-free photosensitive polyimide is synthesized and exhibits good photolithographic properties with a resolution of about 10 μm.
Facet-engineered NaNbO3 cubes with exposed (101) plane for enhanced lithium-ion storage
Authors: Li Hongping , Kang Rong , Song Zhilong , Ng Dickon H. L. , Peng Xiaoshui , Qiao Fen , Yan Jia , Lian Jiabiao
Published: December 2024

NaNbO3 cubes with more exposed (101) facets exhibit superior lithium-ion diffusion, underscoring the significance of crystal facet engineering in enhancing Li+ storage performance.
Green-light-induced selective hydroselenation of olefins with diselenides
Authors: Li Fan , Zhao Hao-Cheng , Wu Hua-Yue , Liu Miao-Chang , Zhou Yun-Bing
Published: December 2024

We have disclosed the selective green-light-induced hydroselenation of alkenes with diselenides using Hantzsch ester as the hydrogen donor.
Predicting mechanical properties of non-equimolar high-entropy carbides using machine learning
Authors: Zhao Xi , Cheng Shu-guang , Yu Sen , Zheng Jiming , Zhang Rui-Zhi , Guo Meng
Published: December 2024

High-entropy carbides (HECs) have garnered significant attention due to their unique mechanical properties.
Efficient and stable inverted MA/Br-free 2D/3D perovskite solar cells enabled by α-to-δ phase transition inhibition and crystallization modulation
Authors: Xu Zhiyuan , Guo Zhihao , Li Haiyun , Zhou Yuqin , Liu Zhenyu , Wang Ke , Li Zhijun , Wang Huaxin , Qaid Saif M. H. , Mohammed Omar F. , Zang Zhigang
Published: December 2024

An FA-based organic derivative, namely BLSCl, has been explored as a spacer for MA/Br-free FA-based 2D/3D perovskites. A champion efficiency of 25.96% for the 0.1 cm2 device and 24.54% (certified 23.94%) for the 1.01 cm2 device have been achieved.
A pilot study of metaproteomics and DNA metabarcoding as tools to assess dietary intake in humans
Authors: Petrone Brianna L. , Bartlett Alexandria , Jiang Sharon , Korenek Abigail , Vintila Simina , Tenekjian Christine , Yancy William S. , David Lawrence A. , Kleiner Manuel
Published: December 2024

In a pilot study of five individuals, we evaluated the concordance between conventional diet records and DNA- and protein-based biomarkers of food intake in their stool.
Screening of the effect of new food prototypes based on fermented lentil and quinoa flours on the colonic microbiota of older adults through a static in vitro colonic fermentation model
Authors: Gomez-Gomez Elena , Asensio-Grau Andrea , Heredia Ana , García-Hernández Jorge , Calvo-Lerma Joaquim , Andrés Ana
Published: December 2024

The formulation of new food concepts based on protein-rich ingredients from legumes or pseudo-cereals seems a promising approach to meet the increased protein demands in the older adults.
The mediating role of C-reactive protein (CRP) in the dietary intake of flavonoids and the risk of albuminuria
Authors: Jiang Feng , Zheng Tiantian , Li Yong Jie
Published: December 2024

Prior experimental investigations have highlighted the beneficial effects of flavonoid consumption on renal function.
Differential effects of EPA and DHA on aging-related sarcopenia in mice and possible mechanisms involved
Authors: Wu Zi-Jian , Li Ying-Chao , Zheng Yan , Zhou Meng-Qing , Li Hui , Wu Shi-Xiang , Zhao Xin-Yue , Yang Yu-Hong , Du Lei
Published: December 2024

EPA has a better anti-sarcopenia effect than DHA in aged mice, and the reason might be due to its superior capability of attenuating mitochondrial dysfunction in skeletal muscle.
Engineering charge transfer in a two-dimensional S-scheme heterojunction photocatalyst via built-in electric field for selective biomass valorization
Authors: Guo Taolian , Dang Rong , Zheng Anyu , Wang Shaodan , Dong Xiongwei , Xiong Zhongduo , Chen Zibo , Hu Zifu , Chen Wu , Wang Chao
Published: December 2024

A two-dimensional MOF-based S-scheme heterojunction photocatalyst with built-in electric field is developed to boost photocatalytic selective conversion of 5-hydroxymethylfurfural.
Nickel-free porous stainless-steel nanocomposites for versatile biomedical applications: fabrication, characterization, and evaluation of electrochemical and immunogenicity detection
Authors: Abdelwahab Sabreen Abdallah , Warda Mohamad , Zewaid Mamdouh , Saleh Hisham , Ahmed-Farid Omar A. , Hendawy Hassan A. M. , Kamoun Elbadawy A. , Negm Amr , Son Jong Yeog , Ali Ahmed I.
Published: December 2024

This study focuses on the development of nickel-free stainless-steel nanocomposites with porosities tailored for surgical implants and biological applications.
Multi-gradient energy-saving smart windows with thermo-response and multimodal thermal energy storage
Authors: Zhou Yang , He Yiqi , Zhao Sisi , Qi Simeng , Wang Lulu , Niu Yingchun , Xu Quan , Xu Chunming , Wang Juncheng
Published: December 2024

Based on high specific heat absorption rate and phase-transition heat absorption performance, “MGES smart window” successfully realizes the characteristics of multi-stage energy saving and heat storage, passive adaptive adjustment, etc.
Stacking-dependent and electric field-driven electronic properties and band alignment transitions in γ-GeSe/Ga2SSe heterostructures: a first-principles study
Authors: Vinh Nguyen V. , Lu D. V. , Pham K. D.
Published: December 2024

In this work, we present a comprehensive investigation into the electronic properties and contact behavior of γ-GeSe/Ga2SSe heterostructures using first-principles calculations.
Reductive O-alkylation of methanol by ketones using a heterogeneous palladium catalyst under continuous flow conditions
Authors: Han Xinxin , Nguyen Remi , Ouyang Weiyi , Hu Mingyou , Len Christophe
Published: December 2024

A mild continuous-flow catalytic process for reductive alkylation of methanol with aliphatic ketones. A mechanism is proposed.
Polyoxometalate-based coordination polymers enhance electrocatalytic hydrogen evolution in trimetallic sulfides
Authors: Zhang Shuyuan , Wang Guangning , Liu Jie , Wang Qian , Zhang Chunjing , Pang Haijun , Li Xiaoyi , Wang Shiming , Chen Tingting
Published: December 2024

Highly efficient and stable trimetallic sulfide MoS2/Ag2S/NiS/NF electrocatalysts are reported, demonstrating a low overpotential and a Tafel slope.
Core–shell structured carbon@tin sulfide@hard carbon spheres as high-performance anode for low voltage sodium-ion battery
Authors: Wang Yueyang , Mao Yulin , Yu Qinglu , Xing Guichuan , Li Qingyuan , Sun Guoxing
Published: December 2024

This study introduces a core–shell C@SnxSy@HCS composite anode for sodium-ion batteries, achieving low discharge voltage (0.5 V), high initial Coulombic efficiency (73.56%), excellent rate capability, and outstanding cycling stability.
Watching lanthanide nanoparticles one at a time: characterization of their photoluminescence dynamics at the single nanoparticle level
Authors: Kayyil Veedu Malavika , Lavilley Gemma , Sy Mohamadou , Goetz Joan , Charbonnière Loïc J. , Wenger Jérôme
Published: December 2024

Photoluminescence burst analysis and fluorescence correlation spectroscopy were used to assess the emission brightness and photodynamics of single Sm- and Eu-based lanthanide nanoparticles (LnNPs) with single nanoparticle sensitivity.
Recent advances in inorganic oxide semiconductor-based S-scheme heterojunctions for photocatalytic hydrogen evolution
Authors: Ullah Ikram , Amin Muhammad , Zhao Pei , Qin Ning , Xu An-Wu
Published: December 2024

We highlighted the synthesis strategies, photocatalytic H2 production, and charge separation mechanisms of inorganic oxide semiconductor-based S-scheme heterojunctions, such as tungsten oxides, titanium oxides, zinc oxides, and copper oxides.
A short review of the sustainable utilization of coal gangue in environmental applications
Authors: Gao Lihui , Liu Yanhong , Xu Keyi , Bai Lu , Guo Nan , Li Shulei
Published: December 2024

This review summarizes the environmental applications of coal gangue and highlights the challenges and future directions of its utilization as a large-scale resource.
Electrochemical reduction method for leaching terbium and cerium from waste phosphors
Authors: Wang Ruixiang , Xu Piao , Xie Boyi , Liu Chaxiang , Zhong Xiaocong , Zhang Zhongtang , Fan Helin
Published: December 2024

Rare earth elements are commonly used in various fields due to their unique physical and chemical properties.
In vivo and in silico evaluation of the phytoalexin-eliciting activity in common bean (Phaseolus vulgaris L.) of jasmonoyl-l-isoleucine analogs having a pyrazolidin-3-one ring
Authors: Páez Samuel Vizcaíno , Durango Diego , Quiñones Wiston
Published: December 2024

Pyrazolidin-3-one analogs of jasmonoyl-l-isoleucine elicit phytoalexin production in Phaseolus vulgaris, and its protein model built by homology shows coherent protein–ligand interactions in the docking approach.
Effect of Bi(iii)-to-metal ion concentration ratios on stripping voltammetric response of bismuth-film glassy carbon electrodes
Authors: Guo Hongwei , Chen Bin , Luo Yingmin , Wang Ruiyang , Tian Qichang , Chang Yanping
Published: December 2024

The effect of cBi/cM ratio on key evaluation indicators, including sensitivity, precision, and cathodic potential range, has been investigated for the determination of Cd and Pb at in situ prepared bismuth film electrodes.
Calcium-atom-modified boron phosphide (BP) biphenylene as an efficient hydrogen storage material
Authors: Abdullahi Yusuf Zuntu , Djebablia Ikram , Yoon Tiem Leong , Leng Lim Thong
Published: December 2024

Gravimetric H2 uptakes of 7.28 wt% and 5.56 wt% were found for b-B3P3(8Ca)@32H2 and g-B6P6(16Ca)@48H2 systems, exceeding the target of 5.50 wt% set by the US Department of Energy (DOE) to be reached by 2025.
Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers
Authors: Zou Kun , Yang Jinyu , Gao Yingxiao , Feng Feng , Wu Mingxuan
Published: December 2024

A robust method is reported to introduce site-specific sulfonium warheads to peptides and proteins by cysteine alkylation. This method enables the preparation of nucleosome probes that crosslink to H3K36 methylation readers LEDGF and NSD2.
A bismuth oxide-modified copper host achieving bubble-free and stable potassium metal batteries
Authors: Shi Guokai , Xie Junpeng , Li Zhibin , Sun Peng , Yin Ying , Pan Likun , Hui Kwun Nam , Mai Wenjie , Li Jinliang
Published: December 2024

The Bi2O3 modified layer contributes to the formation of a stable solid electrolyte interface during charge–discharge process, which significantly suppresses gas evolution in K-ion batteries.
Selection of ssDNA aptamers and construction of an aptameric electrochemical biosensor for detecting Giardia intestinalis cyst protein
Authors: Alhindawi Mohammed , Rhouati Amina , Noordin Rahmah , Cialla-May Dana , Popp Jürgen , Zourob Mohammed
Published: December 2024

Giardia intestinalis, an intestinal protozoan parasite, is one of the potentially severe parasitic infections, especially in children.
From citrus waste to value: optimizing sulfonated carbons for limonene upcycling into value-added products
Authors: Reis Gabrielle M. , Nunes Renan S. , Xavier Gabriela T. M. , Kirillova Marina V. , Kirillov Alexander M. , Mandelli Dalmo , Carvalho Wagner A.
Published: December 2024

Sulfonated carbons facilitate the eco-friendly transformation of limonene into valuable compounds, representing a noteworthy advancement in the field of catalysis.
Untangling the potential of non-entangled bottlebrush block copolymers as separator coating materials for high-rate and long-life sodium metal batteries
Authors: Jeong Daun , Shin Gyu Hwang , Lim Hyojun , Kim Seunghyeon , Kwon Da-Sol , Yook Jinsol , Kim Sang-Ok , Chung Kyung Yoon , Kim Kyeounghak , Shim Jimin
Published: December 2024

A bottlebrush block copolymer (BBP) coating on conventional separators enables the development of high-performance sodium (Na) metal batteries by regulating stable Na electrodeposition and electrolyte–electrode interphases.
Identifying the nanostructure of residual Li in high-Ni cathodes for lithium-ion batteries
Authors: Jin Wooyoung , Kim Yujin , Jang Haeseong , Gu Yehyeon , Kim Namhyung , Lee Hyomyung , Kim Junhyeok , Choi Sinho , Jung Kyu-Nam , Nam Ki-Hun , Cho Jaephil , Cha Hyungyeon
Published: December 2024

Identifying the nanostructure of residual Li in high-Ni cathodes is important for their long-term survival. This paper highlights the in-depth understanding of residual Li in nanoscale and suggests appropriate approaches to control the residual Li.
The growth of nanosized zeolite nuclei inside the pinholes of ultra-thin Pd composite membranes
Authors: Zhang Zhenzhan , Li Jiarui , Bao Feng , Tang Chunhua , Shao Wei , Xie Peiyang , Xu Tianying , Yang Wenjing , Liu Yi , Fu Jie , Liu Ming , Li Hui
Published: December 2024

This study introduces a “region growing method” to in situ grow nanosized zeolite nuclei inside Pd membrane pinholes under ambient conditions, providing a simpler alternative to high-pressure hydrothermal zeolite synthesis.
Advances in peptide/polymer antimicrobial assemblies
Authors: Zhao He , Sun Jiayi , Cheng Yi , Nie Shuaishuai , Li Wen
Published: December 2024

This review highlights the importance of peptide/polymer nano-antimicrobial systems in improving antimicrobial activity, stability, cytotoxicity, and bioavailability.
A high-efficiency blue-LED-excitable broadband Cr3+/Ni2+ co-doped garnet phosphor toward next-generation spectroscopy applications
Authors: Liu Lucheng , Liu Yuanhong , Gao Tongyu , Chen Guantong , Liu Ronghui , Li Xiaodong
Published: December 2024

Cr3+/Ni2+ introduces a strong crystal field Ca3Al2Ge3O12 host to obtain a coordinated energy level position. Heavily doped Cr3+ selectively transfers energy to Ni2+, significantly enhancing the absorption efficiency of blue light.
A review of research progress on prevention and control technologies for arsenic and cadmium composite pollution in paddy soil
Authors: Cui Hao , Chen Bingbing , Yang Fan , Han Tao , Zeng Rui , Lei Lidan , Liu Songqing
Published: December 2024

Arsenic and cadmium in paddy soils pose food safety risks in China due to their transfer to rice grains. This review explores various remediation techniques, highlighting the need for integrated, region-specific solutions to reduce contamination.
The PRL2 Phosphatase Upregulates miR-21 through Activation of the JAK2/STAT3 Pathway to Downregulate the PTEN Tumor Suppressor
Authors: Zhang Zhong-Yin , Li Qinglin , Bai Yunpeng , Cavender Sarah M , Miao Yiming , Nguele Meke Frederick , Lasse-Opsahl Emily L , Zhu Peipei , Doody Gina M , Tao W Andy
Published: December 2024

The Phosphatases of Regenerating Liver (PRLs) are members of the protein tyrosine phosphatase (PTP) superfamily that play pro-oncogenic roles in cell proliferation, migration, and survival. We previously demonstrated that PRLs can post-translationally downregulate PTEN, a tumor suppressor frequently inactivated in human cancers, by dephosphorylating PTEN at Tyr336, which promotes the NEDD4-mediated PTEN ubiquitination and proteasomal degradation. Here we report that PRLs can also reduce PTEN expression by upregulating MicroRNA-21 (miR-21), which is one of the most frequently overexpressed miRNAs in solid tumors. We observe a broad correlation between PRL and miR-21 levels in multiple human cancers. Mechanistically, PRL2, the most abundant and ubiquitously expressed PRL family member, promotes the JAK2/STAT3 pathway-mediated miR-21 expression by directly dephosphorylating JAK2 at Tyr570. Finally, we confirm that the PRL2-mediated miR-21 expression contributes to its oncogenic potential in breast cancer cells. Our study defines a new functional role of PRL2 in PTEN regulation through a miR-21-dependent post-transcriptional mechanism, in addition to our previously reported NEDD4-dependent post-translational PTEN regulation. Together, these studies further establish the PRLs as negative regulators of PTEN.
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
Authors: Liu Anna , Ruetalo Natalia , Raja Xavier Janet P. , Lankapalli Aditya Kumar , Admard Jakob , Camarena-Sainz Miguel , Brucker Sara Y. , Singh Yogesh , Schindler Michael , Salker Madhuri S.
Published: December 2024

Vertical transmission of SARS-CoV-2 during human pregnancy remains highly controversial as most studies have focused on the third trimester or the peripartum period. Given the lack of early trimester data, determining the prevalence of vertical transmission during early pregnancy and assessing the potential risks for fetal morbidity and mortality pose a challenge. Therefore, we analysed the impact of SARS-CoV-2 infection on an endometrial 3D spheroid model system. The 3D spheroids are capable of decidualization and express angiotensin-converting enzyme 2 (ACE2) as well as transmembrane protease serine 2 (TMPRSS2), rendering them susceptible to SARS-CoV-2 infection. Employing this 3D cell model, we identified that SARS-CoV-2 can infect both non-decidualized and decidualized endometrial spheroids. Infection significantly increased the chemokine Monocyte chemoattractant protein-1 (MCP-1) compared to non-infected spheroids. Decidualized spheroids exhibited upregulated Interleukin (IL)-8 levels. Furthermore, RNA sequencing revealed dysregulation of several genes involved in tissue-specific immune response, Fc receptor signalling, angiotensin-activated signalling and actin function. Gene expression changes varied between SARS-CoV-2 infected non-decidualized and decidualized spheroids and genes associated with the innate immune system (CD38, LCN2 and NR4A3) were dysregulated as a potential mechanism for immune evasion of SARS-CoV-2. Altogether, our study demonstrates that endometrial spheroids are a useful model to examine the clinical implications of SARS-CoV-2 vertical transmission, warranting further investigations.
Fluid Intelligence Partially Mediates the Effect of Working Memory on Speech Recognition in Noise
Authors: Marsja Erik , Holmer Emil , Stenbäck Victoria , Micula Andreea , Tirado Carlos , Danielsson Henrik , Rönnberg Jerker
Published: December 2024

Purpose:

Although the existing literature has explored the link between cognitive functioning and speech recognition in noise, the specific role of fluid intelligence still needs to be studied. Given the established association between working memory capacity (WMC) and fluid intelligence and the predictive power of WMC for speech recognition in noise, we aimed to elucidate the mediating role of fluid intelligence.

Method:

We used data from the n200 study, a longitudinal investigation into aging, hearing ability, and cognitive functioning. We analyzed two age-matched samples: participants with hearing aids and a group with normal hearing. WMC was assessed using the Reading Span task, and fluid intelligence was measured with Raven's Progressive Matrices. Speech recognition in noise was evaluated using Hagerman sentences presented to target 80% speech-reception thresholds in four-talker babble. Data were analyzed using mediation analysis to examine fluid intelligence as a mediator between WMC and speech recognition in noise.

Results:

We found a partial mediating effect of fluid intelligence on the relationship between WMC and speech recognition in noise, and that hearing status did not moderate this effect. In other words, WMC and fluid intelligence were related, and fluid intelligence partially explained the influence of WMC on speech recognition in noise.

Conclusions:

This study shows the importance of fluid intelligence in speech recognition in noise, regardless of hearing status. Future research should use other advanced statistical techniques and explore various speech recognition tests and background maskers to deepen our understanding of the interplay between WMC and fluid intelligence in speech recognition.
The Role of Teachers' Unions for School-Based Speech-Language Pathologists: Preliminary Findings From Florida
Authors: Lugo Victor A.
Published: December 2024

Purpose:

The purpose of this study was to investigate the role of teachers' unions for school-based speech-language pathologists (SLPs) and their perceptions of the benefits and barriers to union membership.

Method:

A 44-item survey was used to solicit information about the perceptions of and participation in teachers' unions of 320 school-based SLPs. Directed content analysis of 70 district collective bargaining agreements was also conducted to explore the presence and content of SLP contract provisions.

Results:

Results confirm that teachers' unions collectively bargain on behalf of SLPs as they are often recognized as bargaining unit members. SLP provisions pertaining to salary supplements, caseload and workload caps, opportunities for professional development and mentorship, and alternative evaluations were uncovered. However, SLPs' perceptions of teachers' unions and collective bargaining were mixed. Frequently cited benefits of union membership included improved working conditions, legal and professional protections, and collective bargaining. Common barriers were misunderstandings about the role and responsibilities of unions and monetary costs.

Conclusions:

The findings of this study suggest that teachers' unions are not a widely used support structure for school-based SLPs. Despite the barriers highlighted by participants, unions can collectively bargain for provisions that could improve the living and working conditions of practitioners, such as salary supplements, caseload caps, and professional development. Although unions could improve outreach to SLPs in the schools, SLPs may benefit from additional training and professional development opportunities to support the degree to which they advocate and engage with their bargaining units.

Supplemental Material:

https://doi.org/10.23641/asha.27947940
Drone‐based digital twins for water quality monitoring: A systematic review
Authors: Hamzah Abdulmughni , Aqlan Faisal , Baidya Sabur
Published: December 2024

The rapid advancement of drone technology and digital twin systems has significantly transformed environmental monitoring, particularly in the field of water quality assessment. This paper systematically reviews the current state of research on the application of drones, digital twins, and their integration for water quality monitoring and management. It highlights key themes, insights, research trends, commonly used methodologies, and future directions from existing studies, aiming to provide a foundational reference for further research to harness the promising potential of these technologies for effective, scalable solutions in water resource management, addressing both immediate and long‐term environmental challenges. The systematic review followed PRISMA guidelines, rigorously analysing hundreds of relevant papers. Key findings emphasise the effectiveness of drones in capturing real‐time, high‐resolution spatial and temporal data, as well as the value of digital twins for predictive and simulation‐based analysis. Most importantly, the review demonstrates the potential of integrating these technologies to enhance sustainable water management practices. However, it also identifies a significant research gap in fully integrating drones with digital twins for comprehensive water quality management. In response, the review outlines future research directions, including improvements in data integration techniques, predictive models, and interdisciplinary collaboration.
Eclipse-mapping study of the eclipsing binary KIC 3858884 with a hybrid δ Sct/γ Dor component
Authors: Bókon A. , Bíró I. B. , Derekas A.
Published: December 2024

Aims. Pulsating stars in eclipsing binary systems offer a unique possibility to empirically identify pulsation modes using the geometric effect of the eclipses on the pulsation signals. Here we explore the δ Scuti-type pulsations in the eclipsing binary system KIC 3858884 with the aim of identifying the dominant modes using various photometric methods.

Methods. We used the Kepler short-cadence photometry data. Refined binary model and pulsation parameters were determined using an iterative separation of the eclipsing binary and pulsation signals. We used the photometric residuals, a phase modulation study, and a double eclipse mapping (EM) to identify the host stars of the dominant pulsations. Échelle diagram diagnostics were employed to locate the frequencies most affected by the eclipses. Direct-fitting (DF) methods assuming spherical harmonic surface patterns were explored to determine an orientation for the symmetry axis and to infer surface mode numbers ℓ and m. Ancillary mode number estimates were obtained from reconstructions of general surface patterns using dynamic eclipse mapping (DEM). The use of these methods allowed mode identifications that are independent of asteroseismic models.

Results. We unambiguously established the secondary star as the main source of the pulsations. Seven peaks were found to show pronounced modulations during the secondary eclipses. For the first time, we were able to detect two hidden modes with amplitude intensification during the eclipses. Only one additional frequency appears to originate from the primary. DF results point to an essentially aligned pulsation axis for the secondary. We successfully reconstructed surface patterns and determined mode numbers for most of the selected frequencies with both of our methods. We found one radial and three sectoral modes, (1,−1), (2,±2), and (3,±3). The two strongest modes were both found to be nonradial. The hidden modes were identified as (3,±1) and (2,±1), respectively. We find one additional radial mode to be a combination frequency. The partial disagreement between the results of the two methods may indicate that either the strongest modes deviate from strict spherical harmonics, or that the pulsation axis cannot be constrained by the photometric data alone. Future spectroscopic observations could help in resolving this discrepancy.
Evolution of Sports with Artificial Intelligence
Authors: Rodrigues George , Madiwale Mohd Nauman
Published: December 2024

We cannot imagine things without AI in today’s world, everywhere and is playing a important role and today it’s a day where we can witness that slowly and steadily Artificial Intelligence creeping in into sports as well features like augmented reality and virtual reality are revolutionising the sports. This paper is about examining the impact of technology in sports performance analysis with focus on improving performance of athletes, improved decision making and improving the training methods. And also exploring the challenges of introducing technology into existing practise and also providing solutions to overcome the hurdles and emphasizes the role of DV, AI, VR and AR in revolutionizing the field. Also looking into the success stories of AI into nonsports industry and insights from sports science experts we are able to identify the challenges to apply technology like AI in Elite sports with focus in particular on AI controllability, Data collection an explainability of results. These findings are further more distilled into major key challenges faced by the community of sports analytics providing the road map for research in future and its application.
Analysis of the regulatory game of government environmental protection departments on corporate pollution control
Authors: Song Shibo
Published: December 2024

In recent years, China’s rapid economic growth at the same time, promote the construction of ecological civilization, and constantly improve the enterprise pollution control policy, optimize the environmental protection department on the supervision of corporate sewage behavior, and promote the transformation of the country’s ecological civilization and a strong country. However, there are still many enterprises still lack of environmental awareness, in order to maintain their own interests, constantly “drilling” system “loopholes”, do not take the initiative to invest in pollution control, choose to indulge in the problem of sewage disposal, falsification of enterprise data, so as to obtain improper excess earnings, resulting in a serious negative externality. Serious negative externalities. In this regard, this paper will use the game model to analyze the government’s environmental protection department to govern the degree of strictness, improve the enterprise pollution violation emission punishment mechanism, etc., the impact of the change of these parameters will make the enterprise pollution control behavior to improve. The results of the study show that increasing the management system of environmental protection department personnel and enhancing the punishment for corporate pollution violation discharge behavior can effectively reduce the emergence of corporate pollution violation behavior.
Evaluation of meniscal injury on magnetic resonance imaging and knee arthroscopy in patient with anterior cruciate ligament tear
Authors: Vo Toan Thanh , Nguyen Duc Thien , Dinh Le Nguyen Anh , Van Nguyen Ky Hien , Vuu Hiep Khanh , Le Tu Anh , Le Phan Nguyen Ba
Published: December 2024

Introduction: Meniscal injuries often occur in association with anterior cruciate ligament (ACL) injury. Failure to detect meniscal tears in patients with ACL injuries can lead to more complex tears and make them more difficult to repair. Objective: To determine the degree of correlation between magnetic resonance imaging (MRI) and knee arthroscopy in diagnosing meniscal injuries in patients with ACL tears. Methods: A prospective descriptive study was conducted on 185 patients diagnosed with ACL tears through knee arthroscopy at Thong Nhat Hospital from April 2023 to April 2024. Results: The accuracy of MRI and its correlation with arthroscopy in detecting meniscal injuries is 69.2%, indicating a low degree of agreement between MRI and arthroscopy results. Diagnosis of meniscal injury location has an accuracy of 57.1%, indicating a minimal to low degree of agreement between MRI and arthroscopy results. Diagnosis of the injury region: Accuracy over 85%, with Kappa coefficients ranging from 0.3 to 0.59, p < 0.001. Diagnosis of the morphology of meniscal injuries: Accuracy over 89%, with Kappa coefficients ranging from 0.26 to 0.66, p < 0.001. Conclusion: There is a minimal to moderate correlation between MRI and arthroscopy in detecting, and diagnosing the location, region, and morphology of meniscal injuries in patients with ACL tears. Therefore, caution is advised when diagnosing meniscal injuries based solely on MRI findings in patients with ACL tears.
Functional outcomes of three-corner fusion without triquetrum excision versus conventional four-corner fusion in scaphoid non-union advanced collapse G II and III in active patients: a prospective randomized control trial
Authors: Youssef Khaled Nabil , Nabil Amr , Atiya Ahmed Naeem , El-Mahy Mohammed Mostafa
Published: December 2024

Introduction: Four-corner fusion has long been the preferred treatment for stages II and III of scaphoid nonunion advanced collapse with intact radiolunate articulation. Three corner fusions were then proposed as a more limited procedure with improved ulnar deviation through triquetrum excision. However, we believe triquetrum preservation would decrease the radiolunate contact pressure without affecting the ulnar deviation range. Methods: This prospective randomized study was performed between March 2019 and May 2021 and involved a total of 34 patients who underwent four corner fusions or three corner fusions without triquetrum excision for SNAC grade II and III. The average follow-up period was 2 years. Follow-up included radiological and clinical evaluation (range of motion, grip strength, visual analogue scale, and modified Mayo wrist scores). Results: There were no significant differences between the two groups as regards the postoperative range of motion, grip strength, visual analogue scale, modified Mayo wrist scorers, and complication rate. However, the three-corner fusion group had less mean operative time compared to the four-corner fusion (mean ± SD; 77.6 ± 16.9, 103.8 ± 10.2 min – P < 0.001) respectively. Conclusion: The authors concluded that three-corner fusion without triquetrum excision offered a comparable functional outcome and complication rate to four-corner fusion with less operative time in the three-corner fusion group.
Analyse des Mineral-Puffer-Systems des Blutes
Authors: Cejka Daniel
Published: December 2024

Ein neuer Ansatz zur Beurteilung des CKD-MBD-Syndroms (CKD-MBD: „chronic kidney disease – mineral bone disorder“) ist die Messung des Mineral-Puffer-Systems des Blutes. Mittels der Messung von endogenen Kalziproteinpartikeln (CPP: „calciprotein particles“) und der Bestimmung der CPP-Kristallisations-Zeit ex vivo (T50-Test) kann der Gesamtzustand des Mineral-Puffer-Systems des Blutes festgestellt werden. In Zukunft könnte die Optimierung des Mineral-Puffer-Systems die bisherigen Parameter – Phosphat, Kalzium, Parathormon (PTH) – ersetzen. Entsprechende klinische Studien sind allerdings noch erforderlich.
Atypische spontane bakterielle Peritonitis beim Streptokokken-Toxischen-Schock-Syndrom
Authors: Marin Cuartas Tomas , Nasri Ahmad Farid , Bollmann Stefan
Published: December 2024

Anamnese und klinischer Befund Eine 59-jährige Patientin mit unauffälliger Krankengeschichte stellte sich wegen seit ca. 7 Tagen bestehender wässriger Diarrhöen, starken Unterbauchschmerzen und Fieber vor. Bei der körperlichen Untersuchung war das Abdomen distendiert, die Darmgeräusche waren nicht auskultierbar, und es bestand ein akutes Abdomen mit generalisierter Abwehrspannung sowie deutlich erhöhten Entzündungsparametern.

Untersuchungen Die Computertomografie des Abdomens zeigte einen ausgeprägten Aszites und Zeichen einer Peritonitis. Es bestand die Indikation zur operativen Exploration. Zunächst erfolgte eine Laparoskopie. Hierbei zeigte sich eine diffuse eitrige Peritonitis. Eine Organperforation oder ein anderweitiger Focus konnten ausgeschlossen werden.

Diagnose, Therapie und Verlauf Nach Abstrich-Entnahme erfolgte die ausgiebige Lavage und Drainagen-Einlage. Die bakteriologische Untersuchung und die Blutkulturen zeigten β-hämolysierende Streptokokken der Gruppe A, was zur Diagnose einer spontanen bakteriellen Streptokokken-Peritonitis führte. Die Patientin wurde antibiotisch behandelt, erholte sich zunehmend und konnte beschwerdefrei entlassen werden.

Folgerung Die primäre spontane bakterielle Peritonitis durch Streptococcus pyogenes gehört zu den seltenen Ursache eines akuten Abdomens. Eine frühzeitige Diagnose und sofortige Antibiotikatherapie sind entscheidend für die Prognose.
Berufsbezogener Ü45-Gesundheitscheck: Liegt ein Bedarf bei
Beschäftigten in der Pflege vor?
Authors: Raiber Lea , Kaluscha Rainer , Tepohl Lena
Published: December 2024

Ziel der Studie Die hohen physischen und psychischen Belastungen im
Pflegeberuf können sich negativ auf den Gesundheitszustand der Pflegekräfte
auswirken. Das Modellprojekt „Gesundheitscheck für Pflegekräfte aus dem Stadt-
und Landkreis Karlsruhe“ bot Pflegenden ab dem 45. Lebensjahren – auf Basis
ihrer selbsteingeschätzten Arbeitsfähigkeit mittels Work Ability Index (WAI) –
die Teilnahme an einem berufsbezogenen Gesundheitscheck an. Diese Arbeit
betrachtet die berufliche und gesundheitliche Situation von älteren
Pflegekräften, den (subjektiven) Bedarf für einen Ü45-Gesundheitscheck und zieht
einen Vergleich zwischen Teilnehmer/-innen und Nichtteilnehmer/-innen.

Methodik 1.466 Pflegekräfte im Alter zwischen 45 und 52 Jahre wurden zur
Teilnahme am Ü45-Gesundheitscheck eingeladen und im Nachgang schriftlich
befragt. Die Datengrundlage bildeten 202 Fragebögen (49 Teilnehmer/-innen und
153 Nichtteilnehmer/-innen). Es erfolgte eine deskriptive Auswertung und mittels
Chi2- und Rangsummentests wurden Gruppenunterschiede analysiert.

Ergebnisse Als Hauptbelastungsfaktoren der befragten Pflegekräfte wurden
organisatorische Umstände, hohe Arbeitsintensität sowie unzureichende Entlohnung
identifiziert. Erkrankungen bzw. Beschwerden des Muskel-Skelett-Systems und der
Psyche waren am stärksten verbreitet. 18,6% der Befragten waren eher bzw. sehr
unzufrieden mit ihrem gegenwärtigen Gesundheitszustand. Als stark bzw. sehr
stark gefährdet durch die aktuelle Tätigkeit sahen 39,1% ihre körperliche und
27,6% ihre seelische Gesundheit. 25,9% der Pflegekräfte hielten es für sehr
unwahrscheinlich und 32,4% für eher unwahrscheinlich, dass sie bis zum Erreichen
des Rentenalters in der Pflege tätig sein können. Einen persönlichen Bedarf für
einen Ü45-Gesundheitscheck sahen 63,0%. Gruppenunterschiede zwischen
Teilnehmer/-innen und Nichtteilnehmer/-innen zeigten sich durch eine signifikant
höhere Belastung aufgrund von Muskel-Skelett-Erkrankungen (p=0,0002),
Gesundheitszufriedenheit (p=0,0053), den subjektiven Bedarf für einen
Gesundheitscheck (p<0,0001) und Belastungsfaktoren am Arbeitsplatz
(körperliche Tätigkeiten [p=0,00035], zeitgleiche Bewältigung vieler Aufgaben
[p=0,0380], Umgang mit kognitiv eingeschränkten [p=0,0095] sowie mit
leidenden/sterbenden Patienten/-innen [p=0,0164]).

Schlussfolgerung Die Pflegekräfte berichteten von einem hohen
Belastungsniveau am Arbeitsplatz und häufig von gesundheitlichen
Beeinträchtigungen. Es wird deutlich, dass ein konkreter Bedarf zur
Inanspruchnahme eines berufsbezogenen Ü45-Gesundheitschecks für diese Alters-
und Berufsgruppe besteht.
Psychedelika in der Psychiatrie: eine offene Debatte
Authors: Herwig Uwe , Schnell Knut , Daumann Jörg , Jungaberle Andrea , Koller Gabriele , Mertens Lea Julia , Borgwardt Stefan
Published: December 2024

Der Einsatz von Psychedelika in Psychiatrie und Psychotherapie wird vertieft
wissenschaftlich untersucht, national wie international zunehmend fachlich und
gesellschaftlich diskutiert sowie international bereits teilweise klinisch
praktiziert. Der Artikel bietet eine kurze Standortbestimmung auch hinsichtlich
Evidenzlage, kritischer klinischer Fragen und Risiken. Rechtliche, ethische und
ökonomische Aspekte werden beleuchtet, therapeutische Qualifikationen möglicher
Anwender werden diskutiert und es wird unter Benennung noch aktueller
Herausforderungen auf eine mögliche klinisch-psychiatrische Einbettung
eingegangen. Insgesamt wird besprochen, unter welchen Voraussetzungen in der
Anwendung von Psychedelika ein gewisses Potenzial hinsichtlich Erweiterung des
Behandlungsspektrums psychischer Erkrankungen liegen könnte, insb. angesichts
auch unter derzeitigen Methoden häufig therapieresistenter und chronischer
Verläufe. Auf jeden Fall wären wesentliche grundsätzliche Fragen vor einer
eventuellen Einführung zu klären.