bluuebunny/crossref_metadata_2025 huggingface dataset:
DESFECHO CLÍNICOS ADVERSOS EM RECÉM-NASCIDOS PRÉ-TERMO E AS CONDUTAS FISIOTERAPÊUTICAS CONDUZIDAS DURANTE INTERNAÇÃO EM UNIDADE DE TERAPIA INTENSIVA NEONATAL
Authors: Gauze Kellin Mayara da Silva , Müller Alessandra Bombarda
Published: October 2024

ntrodução: Atualmente, a tecnologia em Unidade de Terapia Intensiva Neonatal (UTIN) e nos mecanismos para suporte vital favorece o incremento da sobrevida de recém-nascidos pré-termo (RNPT). Dentre as complicações da prematuridade, o atraso no desenvolvimento neuropsicomotor é uma das principais consequências na fase extrauterina. Objetivo: Identificar os desfechos clínicos adversos apresentados por RNPT e os procedimentos fisioterapêuticos adotados durante internação em UTIN, conforme revisão de prontuário, apresentando o perfil clínico dos bebês assistidos em UTIN de média complexidade. Método: Estudo prospectivo, observacional e transversal. Trata-se de uma amostra não probabilística, formada por 20 prontuários de RNPT em acompanhamento em UTIN no período de coleta dos dados, que atendessem aos critérios de inclusão e exclusão do estudo. Resultados: Foi encontrado maior prevalência de parto cesárea, sexo feminino, necessidade de O2 suplementar, bem como suporte ventilatório (justificando os 70% de alterações no trato respiratório). Além disso, os RNPT apresentaram média de 33 semanas de idade gestacional, 2100g de peso ao nascimento, notas 8 e 9 no índice de APGAR no 1’ e 5’ respectivamente, e média de 13 dias de tempo de internação. Também se observou que quanto menor o peso e a idade gestacional, maior foi o período de internação, nenhuma das crianças apresentou disfunção neurológica. Conclusão: Considerando o manejo clínico, verificou-se a baixa prescrição de Fisioterapia para os RNPT internados.
Devlet okullarındaki öğretmenlerin kişisel performanslarına, örgütsel dayanıklılıklarına ve okullarındaki kuantum liderlik düzeyine yönelik algılarının çeşitli değişkenler açısından incelenmesi
Authors: Yurdunkulu Adem , Terzi Çetin
Published: October 2024

Bu araştırmanın amacı öğretmenlerin kişisel performansları, çalıştıkları okulların dayanıklılık düzeyleri ile yöneticilerinin kuantum liderlik düzeylerinin incelenmesidir. Araştırma evrenini 2021-2022 eğitim öğretim yılı Düzce ilinde görev yapan 4702 öğretmen, örneklemini ise tabakalı örnekleme yöntemi ile seçilen 409 öğretmen oluşturmaktadır. Araştırmada ‘‘Okul Yöneticilerinin Kuantum Liderlik Davranışları Ölçeği’’, ‘‘Öğretmen Performans Değerlendirme Ölçeği’’, ‘‘Örgütsel Dayanıklılık Ölçeği’’ ve kişisel bilgi formu kullanılmıştır. Verilerin analiz edilmesinde AMOS 21 ve SPSS 24 Paket programlarına başvurulmuş, öğretmenlerin görüşleri çeşitli değişkenler ışığında incelenmiştir. Araştırma sonucunda, erkek öğretmenlerin, kuantum liderlik ve örgütsel dayanıklılık algıları açısından kadın öğretmenlere kıyasla daha yüksek değerlere sahip olduğu, aynı şekilde lisans mezunu öğretmenlerin de yüksek lisans mezunu öğretmenlerden daha yüksek algılara sahip oldukları tespit edilmiştir. Ayrıca, mevcut müdürle çalışma süresi uzadıkça, öğretmenlerin kuantum liderlik, örgütsel dayanıklılık ve performanslarına ilişkin algılarının da artış gösterdiği sonucuna varılmıştır. Buradan hareketle okulların dayanıklılığının yükseltilebilmesi ve kriz yönetiminin sağlanabilmesi için farklı çalışmaların yapılması gerektiği ve mümkün olan tüm paydaşların çalışmaya katılımın sağlanması gerektiği gibi öneriler sunulabilir.
The price of inequality: How state tax policies widen the wealth gap
Authors: Qian Derek
Published: October 2024

State taxation has become particularly regressive in recent decades. Across the country, states have increasingly begun to rely on sales and consumption taxes to fund significant portions of their expenditures. Given that these taxes disproportionately hurt lower classes that spend a larger portion of their income on consumable goods and services, these trends widen wealth gaps. By replacing and reducing progressive income taxes with these regressive forms of taxation, levels of inequality have risen. This paper examines the impact of such state and local taxes on the levels of income inequality within each state. Through empirical analysis, it identifies a substantial and positive correlation between the regressivity of state tax codes, as measured by the relative tax burdens on different income brackets, and the levels of inequality, as quantified by the income share of the top 1%.

In this study, I examine the relationship between state tax policies and income inequality in the United States. By analyzing the tax structures of different states, I identify a significant correlation between regressive taxes, that disproportionately burden the less wealthy, and increased income inequality. Using quantitative data from 2013 to 2019, I show that states that rely more on taxes that burden working class families, like sales and excise taxes, witness larger portions of wealth concentration within the top 1%. These findings suggest that tax policy at the state level significantly shapes wealth distribution and highlight the need for reforms to reduce inequality at the state level.
Evolução dos casos de infarto agudo do miocárdio no sudeste do Brasil: um estudo ecológico
Authors: Nascimento Aragão Vladmir , Gonçalves Pires Fernandes Ingridy Tayane , Aparecida Leoni Elaine , Aparecida Caetano Solange , Vieira Valdemir , Regino Magalhães Plínio , Regino Magalhães Lilian , Lopes Adriane , Batista Flores Péricles Cristiano , De Oliveira Florentino Anelvira , Rodrigues Luciana , Lima do Nascimento Aparecida , Flora de Melo Silvana
Published: October 2024

INTRODUÇÃO: Sabe-se que o Infarto Agudo do Miocárdio é uma doença responsável pela principal causa de morte no mundo, sendo prevalente em regiões com alta densidade populacional, como no caso do Sudeste. OBJETIVO: O estudo ecológico tem como objetivo analisar a epidemiologia dos casos de IAM no Sudeste entre os anos de 2018 e 2023  com informações disponíveis no DataSUS. MÉTODOS: A pesquisa é um estudo descritivo, transversal e analítico, baseado em dados do DATASUS. Incluiu-se  pessoas internadas com diagnóstico de infarto do miocárdio no Nordeste entre 2018 e 2023. Os dados foram extraídos do Sistema de Informações sobre Mortalidade (SIM) e do Sistema de Informação de Câncer (SISCAN). As variáveis foram região, sexo, idade, raça e óbitos, com cálculo de frequências absolutas e percentuais para as variáveis categóricas. RESULTADOS: São Paulo concentrou mais da metade das internações por infarto na região (55,87%). A faixa etária predominante foi de 60 a 69 anos (32,38%), seguida por 50 a 59 anos e 70 a 79 anos. Homens representaram quase dois terços das internações (63,96%), e as maiores proporções de raça foram de Brancos (45,36%) e Pardos (34,85%). As internações aumentaram ao longo dos anos, com pico em 2023 (19,74%). Em 2022 registrou-se mais óbitos (7.046),  porém a maior taxa de mortalidade foi em 2018 (10,10%). CONCLUSÃO: Logo, percebe-se uma extensa concentrações de IAM no Sudeste, com uma considerada taxa de óbitos, sendo necessário investimentos na atenção primária para diminuir tal contingente.
Preparing the Workforce for Ethical, Responsible and Trustworthy AI
Authors: Westover Jonathan
Published: October 2024

This article proposes a holistic multi-pronged strategy for establishing an ethical workforce ready for the rise of AI, beginning with examining the current AI landscape and projections of jobs impacted to understand organizational preparedness needs. Key elements include developing an ethical framework through stakeholder engagement outlining shared principles for responsibility; implementing comprehensive technical and soft-skills training programs; creating new dedicated ethics and data governance roles while expanding existing functions to oversee AI accountability; and integrating metrics and career pathways tied to system and process assessments through an ethical lens to drive cultural normalization. Continuous self-evaluation through qualitative and quantitative metrics aids transparency, justification of investment, and framework improvement. The goal of proactively cultivating stewardship abilities across all functions through values clarification, tailored learning, distributed responsibilities, and self-reflection is positioned as exemplary leadership guiding technology's societal impacts amid workplace transformations from emerging technologies.
Reproducción de Pantala flavescens (Fabricius, 1798) (Odonata, Libellulidae) en la península ibérica y descripción de un posible corredor migratorio desde la costa occidental africana
Authors: Bernal Sánchez Arturo , Conesa García Miguel A. , Cano Villegas Francisco
Published: October 2024

A swarm of Pantala flavescens (Fabricius, 1798) observed in a section of the Barbate River in Cádiz is described. In addition, the reproduction of the species is confirmed in the La Breña and Marismas del Barbate Natural Park. These are the first records of migratory and reproductive behaviour of the species since its presence was first detected in the Iberian Peninsula (BERNAL-SÁNCHEZ & CONESA-GARCÍA, 2021). A possible migratory path of this swarm is also proposed, as well as its dispersion in the Iberian Peninsula.
Consuming Habits Fast Food and the incidence of obesity in elementary school students
Authors: Baithesda  , Juliastri Anggraini Schu  , Autry Alvian Mandagi
Published: October 2024

Obesity has become a global pandemic throughout the world and is declared the largest chronic health problem, making it a major public health problem, including for school-aged children. The aim of this research is to identify the relationship between consumption fast food and the incidence of obesity in elementary school students. Design approach cross-sectional with a student population in one of the elementary schools in Manado City. The number of respondents was 162 people with the criteria being aged 6 years and over and having consent from their parents, taken using techniques quota sampling. Fast food consumption data was collected using a paper-based questionnaire, while the incidence of obesity was measured by BMI. Data were analyzed using the Chi-square test with significance values p ≤ 0.005. The research results showed a significant relationship between consumption frequency fast food with the incidence of obesity in students (p < 0.001). It is recommended for schools to provide school canteens that comply with health standards and for parents to prepare a healthy breakfast for children.
Reducing Depression with Classical Music Therapy in Chronic Kidney Failure Patients Undergoing Hemodialysis
Authors: Vivi Sovianti  , Emilia Puspitasari  , Gianinda Wening Saraswanty  , Maya Cobalt Angio S  , Siti Juwariyah  , Miss Nafisah
Published: October 2024

Background: Chronic Kidney Failure problems during hemodialysis may include depression. Depression refers to the mental, thought, feeling, and behavioral problems
of patients. The causes of depression include genetics, physical disease, lifestyle, and drugs. One of the therapies to relieve depression is music therapy. This research determines the influence of music therapy to relieve the depression levels of chronic kidney failure patients with hemodialysis. The applied method was quantitative with a quasi-experimental design and one group pretest-posttest. The samples consisted of 45
respondents taken by accidental sampling. The applied instruments were BDI and the music therapy SOP. All instruments were examined in terms of validity, reliability, and expert judgment. The statistic test applied a non-parametric Wilcoxon test. The results showed the influence of classical music therapy and the relieved depression levels of chronic kidney failure patients with hemodialysis. The obtained p-value is 0.000, lower
than 0.05. The researcher concluded the implementation of classical music was effective to relieve the depression symptoms of chronic kidney failure patients with hemodialysis. The researcher suggests developing a combined classical music therapy to relieve depression in chronic kidney failure patients. The researcher suggests the implementation of intervention and control groups to compare the significance of the results.
DETERMINANT FACTORS OF THE MENSTRUAL CYCLE IN GRADUATE NURSING STUDENTS
Authors: Sokhifah  , Tin Utami  , Arlyana Hikmanti
Published: October 2024

According to WHO, more than 75% of women experience menstrual disorders and on average occur at the age of 17-29 years. One of the factors that influence the occurrence of irregular menstrual cycles is poor sleep quality. This study aims to determine the relationship between sleep quality and menstrual cycle in undergraduate nursing students at Harapan Bangsa University. This type of research is an analytic survey with a cross sectional design. The population in this study were 316 undergraduate nursing students and a sample of 174 students with Proportional random sampling method. Instruments used Pittsburgh Sleep Quality Index (PSQI) and menstrual cycle questionnaire. Data analysis used bivariate analysis for frequency distribution and univariate data analysis with chi square to determine the relationship. The results of this study obtained the frequency distribution of sleep quality obtained the highest results (79.3%) in the bad category and the menstrual cycle obtained results (67.8%) in the normal menstrual cycle category, with a p value = 0.151 (p> 0.05). The conclusion is that there is no significant relationship between sleep quality and menstrual cycle in Nursing Study Program Undergraduate Students at Harapan Bangsa University
COMPARISON OF VEGETARIANS AND NON-VEGETARIANS IN BODY MASS INDEX INDICATORS AND CHOLESTEROL LEVELS
Authors: Helen Sabatini Simbolon  , Yunus Elon
Published: October 2024

Background: Nutritional status of adults can be seen simply by using body mass index, and especially nutritional status related to vegetarian and nonvegetarian dietary status.Objective: This study aimed to assess the cholesterol levels and BMI of Adventist University Indonesia students. Methods: Using Spearman's rho test, this research technique is quantitative. There were 60 participants who voluntarily gave their consent. The tool used in this study is a lipid profile (measuring tool for cholesterol levels), Results: the study showed that there was no relationship between gender and BMI. While there is a significant relationship to dietary status and cholesterol levels with a unidirectional positive value (p = .000 r = .578).
HUBUNGAN KECEMASAN DENGAN KUALITAS TIDUR PADA LANSIA DI PANTI TRESNA WERDHA PENGASIH REMBOKEN
Authors: Wuon Reisa , Huragana Joksan , Ferdinandus Aprildy
Published: October 2024

Tidur merupakan proses fisiologis penting dalam kehidupan manusia karena gangguan pada siklus tidur mampu berdampak serius pada kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan kecemasan dan kualitas tidur pada lansia di Panti Tresna Werdha Pengasih Remboken yang dilakukan pada bulan Februari-Maret 2022. Metode penelitian adalah cross-sectional dengan teknik total sampling, sebanyak 40 responden lansia yang mengalami gangguan kecemasan dan kualitas tidur di Panti Tresna Werdha Pengasih Remboken. Instrument yang digunakan adalah kuesioner. Variabel dependen adalah kecemasan dan variabel independent adalah kualitas tidur. Hasil penelitian ada hubungan yang signifikan antara kecemasan dan kualitas tidur lansia dengan uji chi square didapatkan hasil p= 0,012<0,05 dengankesimpulan Ha diterima H0 ditolak atau hubungan kecemasan dengan kualitas tidur ada lansia di panti tresna werda penasi remboken. Kebutuhan tidur seseorang tidak hanya dilihat berdasarkan jumlah jam tidur tetapi juga oleh seberapa nyenyak tidur seseorang dan Kualitas tidur merupakan tingkat kepuasan yang dirasakan individu setelah bangun tidur dan jumlah durasi tidur sesuai dengan kebutuhannya
FENDER ET GIBSON: DE LA CONCURRENCE AU PARTAGE DU MARCHÉ
Authors: Dumoulin Régis
Published: October 2024

En stratégie d’entreprise, l’innovation est généralement présentée comme une nécessité, afin que l’entreprise puisse maintenir ou développer son avance sur la concurrence. Qu’elle soit centrée sur le produit ou sur les procédés, l’innovation doit reposer sur la réalisation de nouveaux savoirs et compétences afin de créer de la valeur, donc des ressources financières. Ce discours, omniprésent dans notre économie contemporaine, peut faire oublier qu’il existe certains secteurs économiques pour lesquels le recours systématique à l’innovation n’est pas créateur de richesse et ne constitue ni un avantage concurrentiel ni un argument de vente. La lutherie classique, industrielle ou artisanale, est de ceux-là. Il s’agit de comprendre s’il en est de même pour la guitare électrique solid body, emblème incontesté de la musique rock des années 1960 à nos jours, et instrument électrique le plus vendu au monde. Si l’on compare le violon à la guitare électrique solid body, on peut se figurer d’un côté un instrument traditionnel qui n’évolue plus depuis que l’école de Crémone en a fixé les canons au début du xviiie siècle et de l’autre un instrument moderne qui semble répondre aux exigences des clients tant en matière de gamme diversifiée et étendue que de renouvellement régulier des produits. Si les standards du violon sont désormais installés et partagés par tous les acteurs de la profession, ceux de la guitare électrique semblent toujours en évolution, dans un univers social et musical en constante transformation. Or, l’examen attentif de la guitare électrique solid body, la lecture d’ouvrages de référence et de revues spécialisées ainsi qu’une compréhension de l’histoire de la guitare électrique sous l’angle de l’innovation relativise cette impression de foisonnement. La faute en serait au musicien, qui bien que moderne, serait conservateur au point de rejeter tout renouvèlement de l’instrument. Mais l’entreprise a également sa part de responsabilité. Les deux leaders de l’industrie que sont Fender et Gibson ont chacun imposé un standard de la guitare électrique via des trajectoires de développement différentes. En revisitant sans cesse leur passé, ces firmes se sont partagé le marché et ont empêché, parfois à leur corps défendant, l’émergence d’innovations radicales issues de la concurrence ou même développées en interne. La crise commerciale que 181 traverse actuellement la guitare électrique solid body pourrait peut-être ouvrir des pistes d’évolution plus radicales pour cet instrument.
LA GUITARE ÉLECTRIQUE PURISTE ET VIRTUOSE DES ANNÉES 1940 À 1960 DANS LES INTERPRÉTATIONS DE DJANGO REINHARDT ET GEORGE BARNES
Authors: Waschbüsch Viviane
Published: October 2024

Le guitariste français Django Reinhardt (1910-1953) et le guitariste américain George Barnes (1921-1977) sont deux musiciens de jazz devenus célèbres grâce aux nouvelles stylistiques et au jeu très différencié qu’ils ont apporté à leur instrument. Ils ont permis à l’instrument de se développer à travers des techniques de jeux et ont été parmi les premiers musiciens à voir en la guitare électrique un instrument soliste. Ce n’est que très tardivement, dans les années 1940, que Django Reinhardt commence à jouer avec une guitare électrique. Cela aura des répercussions sur son style et favorisera son passage du jazz manouche au be-bop de ses derniers enregistrements, et plus spécifiquement dans ses œuvres comme Babik et Rhythm Futur. George Barnes, quant à lui, débutera aux États-Unis avec une guitare amplifiée et cherchera très tôt à faire de son instrument de prédilection un instrument soliste et de musique de chambre: « My brother was an electrics expert so he made a microphone out of a carbon container […]. There were no commercially-made instruments available, but a lot of guys were experimenting. In those days the guitarist was the lowest man in the band. If anybody was to be fired, it was the guitarist. Even in big-bands the guitarist was lucky to get an eight bar solo 1 . » On retrouve notamment l’esthétique soliste recherchée par Barnes dans un enregistrement de 1946, George Barnes and His Octet, avec des interprétations de standards du jazz comme I Can’t Give You Anything But Love. En se fondant sur l’analyse d’enregistrements et de partitions, nous mettrons en évidence les modifications stylistiques et esthétiques que l’amplification électrique a apportées au jeu de ces deux musiciens.
Islas del Caribe, ruta para el tráfico de drogas desde Venezuela
Authors: Barahona Chavarría Rolando Rafael
Published: October 2024

La adaptación que las Organizaciones Criminales Transnacionales (OCT) dentro del tráfico ilícito de estupefacientes es muy alta, esta adaptación incluye las nuevas formas del transporte como las nuevas rutas que se utilizan aprovechando las situaciones coyunturales de cada país en los temas sociales, económicos, políticos y culturales, que hacen de este fenómeno una preocupación no solo regional sino que mundial, poniendo en riesgo la seguridad de los países que se ven afectados por el mismo, trayendo inmiscuidos problemas de sicariato, tráfico de personas, extorsiones, secuestros, entre otros. Este artículo está basado en información obtenida y recopilada esencialmente en fuentes abiertas, además de realizar una comparativa de datos a lo largo de un determinado periodo de tiempo, tomando como base los datos del Centro Internacional de Investigación y Análisis contra el Narcotráfico Marítimo (CMCON), en donde se trata de demostrar con argumentos la importancia que tiene el territorio venezolano en la producción y tráfico ilegal de estupefacientes, lo cual es utilizado de manera efectiva por las OCT para sus hechos delictivos, utilizando diversas modalidades como “Deposito Ilegal” y “Lancha Go Fast” en su mayoría, para ampliar conceptos, dichas modalidades pueden ser consultadas en el Catálogo de Modalidades del Narcotráfico Marítimo del CMCON. Posteriormente, se pueden sacar conclusiones basados en la dinámica del narcotráfico actual en el Caribe sudamericano, en donde se puede observar cómo estas OCT trafican diferentes tipos de estupefacientes, principalmente clorhidrato de cocaína (CHC), ya que por su proximidad con Colombia que es el principal productor de esta sustancia ilícita, hace que sea viable el trasiego de este estupefaciente.
Enhancing Data Pipeline Efficiency Using Cloud-Based Big Data Technologies: A Comparative Analysis of AWS and Microsoft Azure
Authors:   Austin Peay state university, Clarksville, Tennessee, USA, Oladimeji Olawumi
Published: October 2024

This study conducts a comprehensive comparative analysis of data pipeline efficiency between Amazon Web Services (AWS) Glue and Microsoft Azure Data Factory, two leading cloud-based big data technologies. As organizations increasingly rely on data-driven decision-making, optimizing data pipeline performance is crucial for processing large volumes of information from diverse sources. The research evaluates AWS Glue and Azure Data Factory based on key metrics such as processing speed, scalability, cost efficiency, and fault tolerance, using synthetic datasets ranging from 10GB to 500GB. The results indicate that AWS Glue consistently outperforms Azure Data Factory in processing speed and scalability, particularly for larger data sets, while Azure Data Factory offers greater cost efficiency for smaller workloads. Additionally, AWS Glue demonstrated superior fault tolerance, recovering more quickly from simulated errors compared to Azure Data Factory. These findings provide valuable insights for businesses and data professionals seeking to select the most suitable cloud platform for efficient data pipeline management. This study contributes to the growing body of knowledge on cloud-based big data technologies by offering an up-to-date evaluation of AWS and Azure's data pipeline efficiency, helping organizations optimize their big data processing strategies.
Transformasi Proses Penjualan dan Distribusi Melalui Solusi Digital Berbasis Web Pada Perusahaan Fashion
Authors: Saputra Radithya , Desanti Ririn Ikana , Tjahjana David
Published: October 2024

Dalam era Industri 4.0, teknologi digital menjadi elemen krusial dalam operasi bisnis, terutama di industri fashion. CV DV Star, yang didirikan pada tahun 2017, menghadapi tantangan signifikan dalam manajemen inventaris, akurasi transaksi, dan sinkronisasi data. Tujuan dari penelitian ini adalah untuk mentransformasi proses penjualan dan distribusi CV DV Star melalui sistem Enterprise Resource Planning (ERP) berbasis web yang terintegrasi. Metode pengumpulan data meliputi wawancara dan observasi, memberikan pemahaman yang komprehensif tentang proses bisnis yang ada di perusahaan. Dengan menggunakan metode prototyping, sistem ERP dikembangkan dengan modul-modul untuk manajemen stok, pemrosesan transaksi, pengawasan produksi, dan pelaporan. Hasil penelitian menunjukkan peningkatan signifikan dalam akurasi data, efisiensi operasional, dan produktivitas keseluruhan. Dengan mengadopsi solusi digital ini, CV DV Star dapat mengelola inventaris dengan lebih baik, memastikan distribusi produk tepat waktu, dan menjaga catatan transaksi yang akurat, yang pada akhirnya meningkatkan daya saing dan produktivitas perusahaan.
Sistem Rekomendasi Pemilihan Menu Brownies Cinta dengan Metode Content Based Filtering
Authors: Fanny Fauziah , Susanto Rudi , Nastiti Faulinda Ely
Published: October 2024

Usaha kuliner di Indonesia, seperti Brownies Cinta Karanganyar, menghadapi tantangan dalam membantu konsumen memilih produk dengan cita rasa terbaik. Penelitian ini bertujuan mengimplementasikan sistem rekomendasi menu Brownies Cinta menggunakan metode Content-Based Filtering dengan algoritma cosine similarity. Sistem dikembangkan melalui tahapan SDLC Waterfall: perencanaan, desain, implementasi, pengujian, dan pemeliharaan. Algoritma TF-IDF digunakan untuk menghitung nilai awal, yang kemudian diolah dengan cosine similarity untuk menghasilkan rekomendasi akurat. Hasil pengujian menunjukkan menu "Lapis Kukus Fruity (Reguler)" dan "Brownies Oven Almond (Reguler)" memiliki nilai cosine similarity tertinggi, mencapai 0.950. Sebaliknya, dokumen D19 dengan nilai cosine similarity terendah dianggap tidak relevan. Kesimpulannya, sistem rekomendasi berbasis konten yang dikembangkan mampu memberikan rekomendasi terbaik dan relevan kepada pengguna. Penggunaan algoritma TF-IDF dan cosine similarity terbukti akurat, meningkatkan kepuasan konsumen dalam memilih produk. Sistem ini membantu konsumen Brownies Cinta menentukan produk yang ingin dibeli, memudahkan proses pemilihan menu.
Cost Contingency Strategies in Building Construction: Evaluating Project Risk Influence
Authors: Mawariza Putri Suci , Beatrix Michella
Published: October 2024

Contingency costs are an important part of construction to achieve successful project management. In determining contingency costs, practitioners have used a very subjective approach. This study discussed the determination of the contingency cost of high-rise buildings in six research object projects, based on the results of risk evaluation. The risk evaluation used in this paper is based on the risks in the construction phase. The method used to know the relationship between risk and contingency costs is simple linear regression with tools. The results of this study indicate that the greater the level of risk, the greater the contingency costs incurred by the project. the risk level contributed 71.6% to the contingency cost, while the rest was influenced by other factors. The equation formed is, that if the risk increases by 1 unit, the total contingency cost will increase by 0.0916 units.
Another Thing We Know about Humanitarian Numbers
Authors: Umayam Hayley
Published: October 2024

The September 2023 Special Issue of the Journal of Humanitarian Affairs (5.1) encourages both academics and practitioners to critically engage with humanitarian numbers. The editors cogently enumerate the qualities and limits of these numbers in their issue introduction. Throughout the introduction, however, there is an underexamined notion that numbers drive humanitarian decision-making. This assumption indeed permeates logics of datafication in humanitarianism yet in practice remains more aspiration than modus operandi. This op-ed proposes an eleventh talking point to the growing critiques of humanitarian numbers: Decisions are driven by more than numbers.
Discovering Root Causal Genes with High Throughput Perturbations
Authors: Strobl Eric V , Gamazon Eric R
Published: October 2024

Root causal gene expression levels – or
root causal genes
for short – correspond to the initial changes to gene expression that generate patient symptoms as a downstream effect. Identifying root causal genes is critical towards developing treatments that modify disease near its onset, but no existing algorithms attempt to identify root causal genes from data. RNA-sequencing (RNA-seq) data introduces challenges such as measurement error, high dimensionality and non-linearity that compromise accurate estimation of root causal effects even with state-of-the-art approaches. We therefore instead leverage Perturb-seq, or high throughput perturbations with single cell RNA-seq readout, to learn the causal order between the genes. We then transfer the causal order to bulk RNA-seq and identify root causal genes specific to a given patient for the first time using a novel statistic. Experiments demonstrate large improvements in performance. Applications to macular degeneration and multiple sclerosis also reveal root causal genes that lie on known pathogenic pathways, delineate patient subgroups and implicate a newly defined omnigenic root causal model.
Reconstructing the phylogeny and evolutionary history of freshwater fishes (Nemacheilidae) across Eurasia since early Eocene
Authors: Šlechtová Vendula , Dvořák Tomáš , Freyhof Jörg , Kottelat Maurice , Levin Boris , Golubtsov Alexander , Šlechta Vlastimil , Bohlen Jörg
Published: October 2024

Eurasia has undergone substantial tectonic, geological, and climatic changes throughout the Cenozoic era, primarily associated with tectonic plate collisions and a global cooling trend. The evolution of present-day biodiversity unfolded in this dynamic environment, characterised by intricate interactions of abiotic factors. However, comprehensive, large-scale reconstructions illustrating the extent of these influences are lacking. We reconstructed the evolutionary history of the freshwater fish family Nemacheilidae across Eurasia and spanning most of the Cenozoic era on the base of 471 specimens representing 279 species and 37 genera. Molecular phylogeny using 6 genes uncovered six major clades within the family, along with numerous unresolved taxonomic issues. Dating of cladogenetic events and ancestral range estimation traced the origin of Nemacheilidae to Indochina around 48 million years ago. Subsequently, one branch of Nemacheilidae colonised eastern, central, and northern Asia, as well as Europe, while another branch expanded into the Burmese region, the Indian subcontinent, the Near East, and northeast Africa. These expansions were facilitated by tectonic connections, favourable climatic conditions, and orogenic processes. Conversely, aridification emerged as the primary cause of extinction events. Our study marks the first comprehensive reconstruction of the evolution of Eurasian freshwater biodiversity on a continental scale and across deep geological time.
Image-based identification and isolation of micronucleated cells to dissect cellular consequences
Authors: DiPeso Lucian , Pendyala Sriram , Huang Heather Z , Fowler Douglas M , Hatch Emily M
Published: October 2024

Recent advances in isolating cells based on visual phenotypes have transformed our ability to identify the mechanisms and consequences of complex traits. Micronucleus (MN) formation is a frequent outcome of genome instability, triggers extensive disease-associated changes in genome structure and signaling coincident with MN rupture, and is almost exclusively defined by visual analysis. Automated MN detection in microscopy images has proved extremely challenging, limiting unbiased discovery of the mechanisms and consequences of MN formation and rupture. In this study we describe two new MN segmentation modules: a rapid and precise model for classifying micronucleated cells and their rupture status (VCS MN), and a robust model for accurate MN segmentation (MNFinder) from a broad range of microscopy images. As a proof-of-concept, we define the transcriptome of non-transformed human cells with intact or ruptured MN after inducing chromosome missegregation by combining VCS MN with photoactivation-based cell isolation and RNASeq. Surprisingly, we find that neither MN formation nor rupture triggers a unique transcriptional response. Instead, transcriptional changes are correlated with increased aneuploidy in these cell classes. Our MN segmentation modules overcome a significant challenge to reproducible MN quantification, and, joined with visual cell sorting, enable the application of powerful functional genomics assays, including pooled CRISPR screens and time-resolved analyses of cellular and genetic consequences, to a wide-range of questions in MN biology.
Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens
Authors: Torelli Francesca , da Fonseca Diogo M , Butterworth Simon W , Young Joanna C , Treeck Moritz
Published: October 2024

Toxoplasma gondii is an intracellular parasite that subverts host cell functions via secreted virulence factors. Up to 70% of parasite-controlled changes in the host transcriptome rely on the MYR1 protein, which is required for the translocation of secreted proteins into the host cell. Mice infected with MYR1 knock-out (KO) strains survive infection, supporting a paramount function of MYR1-dependent secreted proteins in Toxoplasma virulence and proliferation. However, we have previously shown that MYR1 mutants have no growth defect in pooled in vivo CRISPR-Cas9 screens in mice, suggesting that the presence of parasites that are wild-type at the myr1 locus in pooled screens can rescue the phenotype. Here, we demonstrate that MYR1 is not required for the survival in IFN-γ-activated murine macrophages, and that parasites lacking MYR1 are able to expand during the onset of infection. While ΔMYR1 parasites have restricted growth in single-strain murine infections, we show that the phenotype is rescued by co-infection with wild-type (WT) parasites in vivo, independent of host functional adaptive immunity or key pro-inflammatory cytokines. These data show that the major function of MYR1-dependent secreted proteins is not to protect the parasite from clearance within infected cells. Instead, MYR-dependent proteins generate a permissive niche in a paracrine manner, which rescues ΔMYR1 parasites within a pool of CRISPR mutants in mice. Our results highlight an important limitation of otherwise powerful in vivo CRISPR screens and point towards key functions for MYR1-dependent Toxoplasma-host interactions beyond the infected cell.
The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2
Authors: Roy Shamayita , Adhikary Hemanta , Isler Sarah , D'Amours Damien
Published: October 2024

The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex joined to a displaced strand of genomic DNA. While the effects of R-loops on health and disease are well established, there is still an incomplete understanding of the cellular processes responsible for their removal from eukaryotic genomes. Here, we show that a core regulator of chromosome architecture —the Smc5/6 complex— plays a crucial role in the removal of R-loop structures formed during gene transcription. Consistent with this, budding yeast mutants defective in the Smc5/6 complex and enzymes involved in R-loop resolution show strong synthetic interactions and accumulate high levels of RNA-DNA hybrid structures in their chromosomes. Importantly, we demonstrate that the Smc5/6 complex acts on specific types of RNA-DNA hybrid structures in vivo and promotes R-loop degradation by the RNase H2 enzyme in vitro. Collectively, our results reveal a crucial role for the Smc5/6 complex in the removal of toxic R-loops formed at highly transcribed genes and telomeres.
Light-driven synchronization of optogenetic clocks
Authors: Cannarsa Maria Cristina , Liguori Filippo , Pellicciotta Nicola , Frangipane Giacomo , Di Leonardo Roberto
Published: October 2024

Synthetic genetic oscillators can serve as internal clocks within engineered cells to program periodic expression. However, cell-to-cell variability introduces a dispersion in the characteristics of these clocks that drives the population to complete desynchronization. Here, we introduce the optorepressilator, an optically controllable genetic clock that combines the repressilator, a three-node synthetic network in E. coli, with an optogenetic module enabling to reset, delay, or advance its phase using optical inputs. We demonstrate that a population of optorepressilators can be synchronized by transient green light exposure or entrained to oscillate indefinitely by a train of short pulses, through a mechanism reminiscent of natural circadian clocks. Furthermore, we investigate the system’s response to detuned external stimuli observing multiple regimes of global synchronization. Integrating experiments and mathematical modeling, we show that the entrainment mechanism is robust and can be understood quantitatively from single cell to population level.
Hopeful Things as Minor Interventions in Educational Atmospheres
Authors: Staunæs Dorthe , Vertelyte Mante
Published: October 2024

Drawing on scholarship on affects, moods, and affective pedagogies in education, we explore how educators in a Danish gymnasium weaved hopes and anxieties into a school space and the specific things, such as books and bookshelves, to address and improve the inclusion of racialized students in school life. Based on a feminist new materialist and diffractive reading through translation of English-language based concepts through Danish grammar and language, we explore how the concept of the "happy object" as delineated by feminist scholar Sara Ahmed takes on a more hopeful interpretation when analyzed within the Danish educational context and language. We argue that ‘foreign’ concepts require careful consideration and adaptation to suit another (Danish) linguistic, cultural, and racial context. Making such adjustments is not just a matter of taking specificities of local contexts seriously, it is also a means of advancing theory that can inspire analyses conducted in a wider range of educational time-space-coordinates.
Unleashing quantum algorithms with Qinterpreter: bridging the gap between theory and practice across leading quantum computing platforms
Authors: Contreras-Sepúlveda Wilmer , Villegas-Martínez Braulio Misael , Gesing Sandra , Sánchez-Mondragón José Javier , Sánchez-Pérez Juan Carlos , Vidales-Basurto Claudia Andrea , Escobedo-Alatorre J. Jesús , Torres-Palencia Angel David , Palillero-Sandoval Omar , Licea-Rodriguez Jacob , Lozano-Crisóstomo Néstor , García-Melgarejo Julio César , Palacios-Perez Eddie Nelson
Published: October 2024

Quantum computing is a rapidly emerging and promising field with the potential to transform various research domains including drug design, network technologies, and sustainable energy solutions. Due to the inherent complexity and divergence from classical computing, several major quantum computing libraries have been developed to implement quantum algorithms, namely IBM Qiskit, Amazon Braket, Cirq, PyQuil, and PennyLane. These libraries enable quantum simulations on classical computers and execution on corresponding quantum hardware, such as Qiskit programs on IBM quantum computers. Despite the variations among these platforms, the core concepts remain the same. One notable challenge is the absence of a Python-based quantum interpreter to connect these five frameworks, a gap that remains to be fully addressed. In response, our work introduces a tool called Qinterpreter, accessible through a user-friendly web interface, the Quantum Science Gateway QubitHub, which operates alongside Jupyter Notebooks. Built using the Python Object-Oriented Programming System, Qinterpreter unifies the five well-known quantum libraries into a single framework. Designed as an educational tool for students and researchers entering the quantum domain, Qinterpreter enables the straightforward development and execution of quantum circuits across such platforms. This work highlights the quantum programming versatility and accessibility of Qinterpreter and underscores our ultimate goal of pervading Quantum Computing through younger, less specialized, and diverse cultural and national communities.
Construction of a workshop protocol on psychotherapeutic competences for the management of complex depression in institutional primary care setting
Authors:   , Zúñiga Caiseo Ana Karina
Published: October 2024

Background: In Chile, the prevalence of depression is high, constituting one of the main reasons for seeking mental health assistance in institutional settings, but psychologists who are working in primary care report having weak competences for treating depression and unlike in other countries, there is a lack of competence frameworks to equalise the performance of professionals. Aim: To construct a workshop protocol on psychotherapeutic competences for the management of complex depression aimed at psychologists working in primary care. Methodology: A mixed sequential exploratory design was employed that comprised two studies: a qualitative one (GT) to explore psychotherapeutic competences from the protagonists' perspective; and another that involved the construction of workshop protocol and its validation with a Delphi methodology. Results: It is proposed a framework of competences that comprises four domains: knowledge (i.e. knowing about depression and its comorbidities); technical competences (i.e. knowing what to do and adapting techniques); interpersonal competences and attitude (i.e. being welcoming, active, and engaged); and professional and personal competences (i.e. being flexible in the exercise of one's role). Based on these frameworks, it constructed the workshop protocol validated with a consensus ≥80% composed by six modules: 1) theoretical-empirical basis of the protocol; 2) complex depression; 3) objectives, goals, focus, and crisis intervention; 4) suicide risk; 5) therapeutic relationship; 6) social dimension and networks in depression management. Discussion: It is highlighted the integration of patients, psychologists and experts perspectives to proposed a transtheoretical framework of competences and the challenges to construct a workshop protocol to train them. Conclusion: a framework of competences and a workshop protocol to train them are proposed to guarantee more appropriate psychological care of depression in primary health care.
Clinicopathological and Prognostic Significance of PD-L1 Expression in Male and Female Breast Carcinoma Cases: A Cohort Study
Authors: Dey Soumya , Rana Samir , Nandy Sujit , Mondal Madhumita , Datta Chhanda
Published: October 2024

Introduction: Male Breast Carcinoma (MBC) is rare compared to Female Breast Carcinoma (FBC) and differs significantly in tumour biology. The expression of Programmed Death receptor-1 (PD-1) and its ligand, Programmed Death-ligand 1 (PD-L1), is extensively studied in FBC for the implementation of newer immunotherapies; however, the role of these immunomarkers in MBC is still not well understood. Aim: To evaluate the expression of PD-L1 in MBC and FBC patients and to assess its clinicopathological and prognostic significance. Materials and Methods: This cohort study was conducted in the Department of Pathology of IPGMER and SSKM Hospital in Kolkata, West Bengal, India, in collaboration with the Department of Surgery over a period of 4 years from January 2020-December 2023. Histopathological examinations were performed on 204 mastectomy specimens from male and female breast cancer patients. Immunohistochemistry for PD-L1, Oestrogen Receptor (ER), Progesterone Receptor (PR), and HER2/neu was conducted on Formalin-fixed Paraffin-embedded (FFPE) tissue. The clinicopathological parameters were analysed alongside PD-L1 expression in breast carcinoma for both genders. Kaplan’s-Meier graphs were plotted for survival analysis. The Statistical Package for the Social Sciences (SPSS) version 29.0 was used for data analysis, with a significance threshold set at a p-value of <0.05 (Chi-square test). Results: The age range was 48 to 65 years in the male population and 30 to 74 years in the female population. A total of 204 cases were included in the study, with 50 cases of MBC and 154 cases of FBC. PD-L1 expression was observed in 48% of MBC cases and in 52.59% of FBC cases. No significant difference in PD-L1 expression was noted between MBC and FBC (p-value=0.572). MBCs exhibited different biological characteristics, including a predominance in older age, smaller tumour size, and more frequent luminal molecular types compared to FBC, with the luminal A subtype being the most common in MBC (38%), while the triple-negative subtype was the most common in FBC (35%). Overall survival analysis also did not demonstrate significant survival advantages in PD-L1 positive cases (p-value=0.491 for MBC cases and 0.128 for FBC cases). Conclusion: PD-L1 expression in MBC does not differ significantly from that in FBC. Furthermore, PD-L1 expression did not confer significant survival advantages in either MBC or FBC cases.
Counterweight, Carrot, Crucible: Theorizing “Community” in Community Treatment Orders
Authors: Barron Gary R. S. , Dyck Joseph I. , Granzow Michael
Published: October 2024

The idea of community in community mental health has recently been criticized as problematic in that it has been ill defined, under-investigated and under-theorized. In this article we introduce actor-network theory as a useful framework for the analysis of everyday psychiatric and legal interventions and their effects. We focus on the community treatment order (CTO) in Alberta as one such intervention, showing how community positions people diagnosed with mental illness as risky subjects. In examining the CTO as an important actor in the construction of mental illness, we argue that the idea of community acts as a counterweight to balance rights, a carrot in a mechanism of consent, and as a crucible where interpretive work on a subject must be done in chains of examinations. Further, we propose a procedural and relational definition of community to inform scholarly work as well as professional practice.
Efficacy of Different Bio-agents, Botanicals, Fungicides and Nano-fungicides against Pyricularia oryzae
Authors: Raghuvanshi Himendra Raj , Biswas S. K.
Published: October 2024

A study was conducted during the period 2021-2023 at, Department of Plant Pathology, Chandra Shekhar Azad University of Agriculture and Technology, Kanpur and the field experiments at Student Instructional Farm, Chandra Shekhar Azad University of agriculture and Technology, during research period different bio-agent, botanicals, Azotrix (Azoxystrobin 16.7 % + Tricyclazole 33.3% SC) and nanofunficides are used and data were recorded regarding there efficacy in inhibition of mycelial growth of Pyricularia oryzae causing rice blast in Completely randomised design (CRD) under in-vitro condition by adopting principle of dual culture technique and  food poision technique. All the selected treatments proved effective and reduce mycelial growth of pathogen, among bioagents T. viride (46.47%) were superior over T. harzianum (43.26 %) and Pseudomonas fluorescence (57.71 %) was better than Bacillus subtilis (48.54%), in botanicals bael leaf extract were found superior (86.32%) over neem leaf extract (74.43%), Fungicide (Azotrix @ 25, 50 and 100ppm) can reduce growth upto 85% over control and among nanofungicides Silver nanoparticles @10ppm was found best which can inhibit (61.87%) mycelial growth.