bluuebunny/crossref_metadata_2025 huggingface dataset:
Гранульований доменний шлак як сорбент органічних барвників
Authors: Грайворонська І. , Хоботова Е. , Даценко В. , Черепньов І.
Published: February 2021

Визначено властивості гранульованого доменного шлаку «АрселорМіттал Кривий Ріг», що зумовлюють його сорбційну активність. У складі фракцій шлаку ідентифіковані мінерали: окерманіт Ca2MgSi2O7, геленіт Ca2Al(Al,Si)2O7, ранкініт Ca3Si2O7, псевдоволластоніт CaSiO3, мервініт Ca3MgSi2O8, мікроклін КAlSi3O8, кальцит CaCO3, ольдгаміт CaS з вмістом алюмосилікатів кальцію і магнію > 50 %. Деякі фази знаходяться в аморфному сорбційно-активному стані. Показана доцільність активації водою протягом 1 доби, в результаті якої на поверхні утворюються і дисоціюють гідроксильні і гідрофільні силанольні групи з формуванням негативного заряду поверхні шлакових частинок, що характерно для алюмосилікатів Са і Mg, а також мінералів кальциту і ольдгаміту. Форма ізотерми адсорбції свідчить про утворення полімолекулярних шарів органічного барвника метиленового синього (МС), що збільшує ефективність шлакового сорбенту. Величина адсорбції МС не менш 2 мг/г. Показано відсутність десорбції МС з шлаку, що забезпечує безпеку як захоронення відпрацьованого сорбенту, так і його утилізації в якості наповнювача будівельних матеріалів. Доведено радіаційну безпеку шлаку. Питома ефективна активність фракцій шлаку не перевищує 370 Бк/кг, що дозволяє його використання в якості технічних матеріалів без обмежень. Запропоновано технологічну схему адсорбційної очистки стічних вод підприємств органічного синтезу і текстильної промисловості, що містять органічні барвники, за допомогою шлакового сорбенту.Стадії технологічного процесу: надходження шлаку з відвалу, аналіз мінерального складу шлаку, водна активація шлаку, статична сорбція барвників в відстійнику, подальша утилізація шлаку і надходження очищених вод в первинне виробництво. Технологія передбачає видалення органічних барвників із стічних вод і їх повторне використання, що забезпечує замкнутість циклу оборотного водоспоживання, відсутність витрат хімічних реагентів на активацію шлакового сорбенту, поліпшення екологічної ситуації в місцях розташування шлакових відвалів за рахунок використання шлаків в якості сорбентів.
Обгрунтування механізованого процесу збирання насіння соняшників
Authors: Мартишко В.
Published: February 2021

Наведено результати теоретичних досліджень процесу збирання соняшнику із застосуванням пристроїв зернозбирального комбайна, визначено допустиму швидкість комбайна при умові мінімального осипання насіння, доведено ефективність використання збирально – транспортних загонів.
The Objective Reality of Speleoclimatotherapy (SCT) in Sylvinite Speleo-Climatic Chambers (SCC) as Therapeutic Natural Resource
Authors: Bokhan A. N. , Vladimirskiy E. V. , Gorbunov YU. V. , Eremushkin M. A. , Rasumov A. N. , Faynburg G. Z.
Published: February 2021

Сильвинитовая спелеоклиматотерапия (СКТ) более 45 лет развивается в России и Белоруссии как немедикаментозная технология, использующая широкие возможности воздействия на организм человека природного сильвинита (ПС), в том числе неинвазивно. Воздействие СКТ на гомеостаз организма нормализует функционирование всех жизненно важных систем и эффективно влияет на аллергические и хронические заболевания. Эффективность влияния СКТ на восстановление дыхательных функций организма позволяет использовать данный метод при реабилитации COVID-19.
Possibilities of Natural and Preformed Physical Factors Application in Pregravid Preparation of Women with Chronic Infl ammatory Diseases of Uterine Appendages: Scientifi c Review
Authors: Kotenko N. V , Borisevich O. O.
Published: February 2021

Представлен обзор методик и подходов физической медицины, применяемых в прегравидарной подготовке женщин с хроническими воспалительными заболеваниями придатков матки. Хронический неспецифический сальпингоофорит является достаточно распространенной проблемой у женщин детородного возраста, что негативно сказывается на состоянии репродуктивного потенциала популяции. Кроме того, симптомокомплекс, возникающий при данной патологии, оказывает негативное влияние на психоэмоциональное состояние, социальные взаимоотношения, микроклимат в семье, трудоспособность, что в итоге значительно снижает качество жизни пациенток. Благодаря возможностям современной медицины наряду с применением медикаментозных этиопатогенетических методов лечения стала обоснованной терапия природными и преформированными физическими факторами. Мы постарались расширить взгляды современного врача на возможности консервативного лечения хронических воспалительных заболеваний придатков матки.
Analysis of Hydrozine Sulfate Eff ect on the Course of Oncological Desease
Authors: Ansimova P. V. , Boldina N. V.
Published: February 2021

В данное время актуальной является проблема корреляции между психопатологической симптоматикой, выявляемой у пациентов со злокачественными новообразованиями, и общим состоянием здоровья, качеством жизни. Во-первых, онкологическая патология нарушает психическое здоровье и является провоцирующим фактором появления психопатологических симптомов, во-вторых, такие психические расстройства, как депрессия, дисфагия, астения, нарушают социальную адаптацию пациентов, что сказывается на качестве их жизни.
Methods of Physical Rehabilitation in Arterial Hypertension
Authors: Lebedeva O. D.
Published: February 2021

Для изучения возможностей применения электростимуляции и общих йодобромных ванн у больных с артериальной гипертензией было обследовано 120 больных с АГ II стадии, II степени, которые были рандомизированы на 3 группы по 40 человек. При применении лечебного комплекса установлена достоверно большая эффективность комплексного применения электростимуляции и йодобромных ванн по сравнению с монотерапией электростимуляцией, а также с контрольной группой, нормализация АД, улучшение психоэмоционального состояния, снижение функциональной реактивности сердечно-сосудистой системы при психоэмоциональной и физической нагрузках, регрессия гипертрофии миокарда на 9,8 %, улучшение систолической и диастолической функции миокарда левого желудочка, снижение показателя симпатовагального баланса на (52,4 %). Полученные результаты свидетельствовали, в целом, о нормализации гемодинамики и об оптимизации вегетативной регуляции функции сердечно-сосудистой системы у больных артериальной гипертензией.
Natural Therapeutic Mud of the Republic of Karelia
Authors: Parfenov A. A. , Limonov V. I.
Published: February 2021

Как и многие субъекты Российской Федерации, Карелия богата природными курортными факторами. Существенные резервы минеральных вод, лечебных грязей, прекрасный климат в сочетании с современной медицинской базой выводят Карелию на одно из ведущих мест в стране по применению природных лечебных факторов в системе санаторно-курортного оздоровления населения. В статье рассмотрены основные природные лечебные грязи территории.
Aspects of Prevention and Treatment of Stroke Complicated by Metabolic Syndrome
Authors: Musaeva O. M. , Nuvakhova M. B.
Published: February 2021

Сердечно-сосудистые заболевания, в частности инсульты, являются одной из наиболее значимых проблем в современной медицине. Очень часто инсульты являются следствием так называемого метаболического синдрома. Данная статья описывает некоторые аспекты лечения и профилактики подобных состояний.
The effect of C-reactive protein, procalcytonine, nuetrophil/lymphosite levels on mortality and duration of hospital stay in pneumonia
Authors: BEYAZ Ahmet , ATİLLA Nurhan , ARPAĞ Hüseyin , BOZKUŞ Fulsen , KAHRAMAN Hasan , UĞUZ Fatih
Published: February 2021

Aim: The aim of this study is to investigate the effects of procalcitonin (PCT), C-reactive protein (CRP) and neutrophil lymphocyte ratio (NLR) levels on the mortality and duration of hospital stay in patients diagnosed with pneumonia.
Material and Method: The study included 111 cases of pneumonia followed in our chest diseases service and intensive care unit between 2017 and 2018. Collected data included demographic information, NLR, PCT, CURB-65 scores. The data were evaluated by parametric tests (Paired sample T test, Independent sample T test). Correlation between the data was done by Chi-square test. P value <0.05 was considered statistically significant.
Results: A statistically significant positive correlation was detected between PCT and NLR (p <0.001; r = 0.343), PCT and CRP (p <0.001; r = 0.502), NLR and CRP (p <0.001; r = 0.427). There was a statistically significant correlation between mortality and CRP (p <0.001; 0.427), PCT (p <0.001; r = 0.343) and NLR (p = 0.013; r = 0.235). There was a statistically significant correlation between duration of hospital stay and PCT (p = 0.036; r = 0.199) and NLR (p = 0.030; r = 0.206) but not with CRP (p = 0.298; r = 0.102).
Conclusion: Besides PCT and CRP, NLR can also be used for prognosis estimation in pneumonia patients.
Evaluation of oxidative stress in pregnants with chronic hepatitis B and C
Authors: AKAR Mustafa , BAŞKOL Gülden , YÜCESOY Mehmet
Published: February 2021

Aim: This study was aimed to investigate the levels of antioxidant markers (paraoxonase, superoxide dismutase, glutathione peroxidase, and thiol) and oxidative stress markers (advanced oxidation protein products, xanthin oxidase, nitric oxide, malondialdehyde, and 8-hydroxydeoxyguanosine) in pregnant women with chronic hepatitis B and C.
Material and Method: Sixty pregnant women in the last trimester, 20 of whom had chronic hepatitis B, another 20 of whom had chronic hepatitis C, and the remaining 20 of whom were healthy controls, were enrolled in this study. Demographic, clinical and laboratory data were recorded for all patients.
Results: When compared to the healthy controls, the pregnant women with chronic hepatitis B and C displayed significantly lower levels of paraoxonase, glutathione peroxidase, and thiol (p<0.001). Superoxide dismutase levels were also lower in the chronic hepatitis B and C patients, in comparison to the healthy controls, yet this difference was statistically insignificant (p=0.76). Compared to the healthy controls, the chronic hepatitis B and C patients had significantly higher levels of advanced oxidation protein and xanthine oxidase (p<0.001). The nitric oxide levels of the chronic hepatitis B and C patients were significantly lower than those of the control group (p<0.05). No statistically significant difference was observed between the chronic hepatitis B and C patients and the controls for malondialdehyde and 8-hydroxydeoxyguanosine levels (p>0.05).
Conclusion: Oxidative stress had significantly increased in pregnant women chronically infected with the hepatitis B and C viruses, when compared to healthy pregnant women. Thus, we suggest that pregnant women chronically infected with the hepatitis B and C viruses should be closely monitored throughout pregnancy for diseases induced by oxidant-antioxidant imbalance, such as preeclampsia, gestational diabetes and gestational hypertension.
Radiologic features of pulmonary cement embolism after percutaneous vertebroplasty in a case and review of literature
Authors: ATEŞ Fatih , KILINÇER Abidin , CEBECİ Hakan , DURMAZ Mehmet Sedat
Published: February 2021

Percutaneous vertebroplasty is a well-known treatment modality for vertebral compression fractures caused by osteoporosis and malignant metastases. The procedure involves the injection of polymethyl methacrylate (PMMA, bone cement), into the desired vertebral body. Pulmonary cement embolism (PCE) refers to the embolization of PMMA into the pulmonary arteries. Patients are often asymptomatic and it may be detected incidentally for imaging done for another reason. The most common symptoms of pulmonary cement embolization are chest pain and breathlessness, and rarely it can present as acute respiratory distress syndrome. In this case, we aimed to present a 73-year-old male patient of PCE with computed tomography (CT) images. We want to raise the awareness that all patients undergoing vertebroplasty procedure should have routine chest X-ray after the procedure. However, CT is the best modality to determine PCE.
A „koncepciós per” és az önkény
Authors: Bócz Endre
Published: February 2021

The author provides an overview of the terminology and history of politically controlled trials in communist Hungary.
« Au revoir, Rose »
Authors: Lucksch Marlène
Published: February 2021

L’auteur développe le cas douloureux d’une mère migrante sans papiers souffrant de graves troubles mentaux et de sa fille, qui montrera très vite des signes d’autisme. Comment le système de protection sociale peut-il prendre en charge l’enfant tout en respectant le lien avec la mère, très malade et n’arrivant pas à se fixer dans un lieu donné ? L’idéologie du lien biologique à tout prix ne pèse-t-il pas fortement dans les institutions ?
Les visages contemporains de la révolte
Authors: Gardenier Matthijs
Published: February 2021

Le modèle classique de la sociologie des mouvements sociaux ne permet que partiellement d’expliquer de nombreuses mobilisations telles que les Gilets jaunes en France, le mouvement de contestation au Chili de 2019 ou encore les mobilisations suite au décès de George Floyd aux États-Unis en 2020. Cet article essaie de renouveler ces grilles interprétatives en questionnant la liquidité des revendications, la figure de la « foule sans maître », ainsi que le rapport de ces mouvements à la souveraineté de l’État.
Les réfléchissants. Gilets Jaunes, ronds-points et nulle part ailleurs
Authors: Joron Philippe
Published: February 2021

Si les motivations premières du mouvement des Gilets jaunes initié en novembre 2018 étaient essentiellement d’ordre économique, d’autres revendications politiques et sociétales ont émergé au fil des protestations. Dans l’avancée des « samedis jaunes » en Actes, le débat sur la consultation directe des Français s’est imposé. Il portait sur les modes de production des propositions gouvernementales, entre les impulsions données par la présidence et le rôle joué par l’Assemblée nationale et le Sénat, les deux chambres du Parlement. C’est tout l’édifice de la démocratie représentative qui était alors remis en question, avec l’appel à l’instauration d’un Référendum d’Initiative Citoyenne (RIC) pour toute question portant à la fois sur les grandes lignes d’orientation politique et sur les aspects les plus concrets de la vie quotidienne des Français.
Turkey’s Healthcare Policies and the COVID-19 Pandemic
Authors: Mardin F. Deniz
Published: February 2021

During the pandemic, health policies have been affected by many factors. The primary concerns are the current health system, human resources for health and an epidemic management strategy. Due to the ‘Health Transformation Program’, health services in Turkey have changed in terms of structure, service delivery and financing. Increasing investments in therapeutic services and private-public cooperation within the scope of the program has made preventive healthcare services weak in terms of structure and health personnel. Although interventions for the management of the outbreak were initiated quickly, the failure to fully implement a suppression strategy and the early removal of the interventions, have led to an increase in the number of cases. Also, a lack of transparency in data sharing has led to the failure to properly organise health services for epidemic control and has shaken the public’s trust in public institutions. In addition, due to the changing health system, people and institutions with knowledge in epidemic management were not able to transfer their experience, which prevented necessary and effective interventions from being carried out on time. As a result, it became impossible to develop effective and rapid health policies during the epidemic in a country that is constantly changing in terms of both structural and human resources for health, there is no transparency for data sharing and scientists are forced into the role of consultants and are not able to participate in the stages of policymaking.
Treatment of urinary tract infections with medicinal plants: Monographs of some plants species revealed by traditherapists
Authors: Dougnon Victorien , Assogba Phénix , Koudokpon Hornel , Ayena Césaire , Vissoh Sosthéne , Akpaka Géraldine , Klotoe Jean Robert , Baba-Moussa Lamine , Bankole Honoré , Koudouvo Koffi , Dougnon Jacques
Published: February 2021

Medicinal plants are a precious heritage for humanity and especially for the majority of poor communities in developing countries who depend on them for primary health care and livelihoods. They are used in traditional practices against urinary tract infections without any scientific evidence for most of the species used. This work aims to have a summary of the literature on some medicinal plants used in the treatment of urinary tract infections. To do this, this study was carried out based on the different medicinal plants cited by herbalists in southern Togo against urinary tract infections. The names of these different plants have each been the subject of research with keywords in search engines such as Google Scholar, PubMed, FreefullPdf, and others to bring out the traditional use of these plants in the world. From all of the above, it appears that the medicinal plant species cited by actors of the Togolese pharmacopoeia are used to treat several diseases in the world. The organs of these plants, such as leaves, bark, and roots are used in the treatment of common illnesses such as typhoid fever, diarrhea, malaria, bronchitis, and hypofertility. Coughs, colds, skin diseases, toothache, gonorrhoea, viral infections, and many other diseases are treated with these plants. The plants are often combined with other plants in traditional medicine. They are used in the form of decoction, fumigation, herbal tea, and others. The type of disease treated by the plants changes from region to region and is also dependent on the culture of the region in the world. The use of medicinal plants is a very ancient practice. It is a very suitable alternative to modern medicine. However, there is a need to have more detailed studies on these plants, such as their toxicological effects.
Effects of Rosmarinic Acid on DNA Integrity and H19 Differentially Methylated Region Methylation Levels in Human Sperm Preserved by Freeze-Drying
Authors: Wang Yi-Yu , Zhu Wei-Jie
Published: February 2021

Abstract

Objective:

To investigate the effects of rosmarinic acid (RA) on the DNA integrity and methylation levels of the H19 differentially methylated region (DMR) of freeze-dried human sperm after 1 week and 6 months of storage at 4°C.

Methods:

Semen samples from 15 healthy normospermic donors were used in this study. The samples were divided into five groups, including the control group with fresh sperm and four experimental groups with freeze-dried sperm (1-week storage with EGTA buffer solution, Group A; 1-week storage with EGTA buffer solution containing 105 μmol/L RA, Group B; 6-month storage with EGTA buffer solution, Group C; and 6-month storage with EGTA buffer solution containing 105 μmol/L RA, Group D). DNA integrity was evaluated using the sperm chromatin dispersion test. H19 DMR methylation levels were detected by bisulfite sequencing polymerase chain reaction.

Results:

After 1 week of storage, no differences in sperm DNA integrity were observed among Groups A, B, and controls (P > 0.05). After 6 months of storage, the sperm DNA integrity of Group D did not change significantly compared with that of the control group (P > 0.05), whereas that of Group C decreased significantly (P < 0.05). There were no differences in H19 DMR methylation levels among the five groups (P > 0.05).

Conclusions:

The DNA integrity of freeze-dried human sperm can be effectively protected by adding RA within 6 months, and the H19 DMR methylation level of human sperm can be maintained for 6 months after freeze-drying.
Molecular detection of plasmid-derived AmpC β-lactamase among clinical strains of Enterobacteriaceae in Bahrain
Authors: Joji Ronni Mol , Al-Mahameed Ali Ebrahim , Jishi Thamer Al , Fatani Dania Ismail , Saeed Nermin K. , Jaradat Ahmed , Ezzat Hicham , Bindayna Khalid Mubarak
Published: February 2021

BACKGROUND:

Enterobacteriaceae with AmpC β-lactamase are multidrug-resistant organisms and represent a significant challenge to patient care. This study aims to determine the prevalence of plasmid-derived AmpC β-lactamase among extended spectrum β-lactamases (ESBL)-producing Enterobacteriaceae strains in Bahrain.

METHODS:

It was a cross-sectional study. A total of 185 ESBL-producing Enterobacteriaceae isolates were recovered from clinically significant specimens from January 2018 to December 2019. The samples underwent initial screen for cefoxitin resistance by disc diffusion test and subsequent phenotypic confirmation of AmpC production with phenyl boronic acid assays as well as genotypic analysis by multiplex polymerase chain reactions for AmpC subtypes. Drug-resistant features of these clinical isolates were also examined.

RESULTS:

Twenty-nine ESBL-producing Enterobacteriaceae isolates were cefoxitin resistant. Phenotypic and genotypic analyses confirmed that 8 and 12 cefoxitin-resistant isolates are AmpC positive, respectively. These AmpC producers are multidrug resistant, and Escherichia coli is the dominant strain among them.

CONCLUSIONS:

Plasmid-mediated spread of AmpC is present in clinically relevant Enterobacteriaceae species in Bahrain. Rational antimicrobial therapy against these multidrug-resistant organisms and continued surveillance of antimicrobial resistance mechanisms among the clinical isolates are recommended for optimal patient care.
Management of Pemphigus Vulgaris and Bullous Pemphigoid in Times of Covid-19 Pandemic
Authors: Salunke Tejaswini , Kulkarni Vinay , Bhide Dhanashree , Vaidya Pradyumna
Published: February 2021

Background:

The pandemic the world is facing today started in the city of Wuhan, central China, in December 2019, and presented as unexplained lower respiratory infections. On February 11, 2020, the World Health Organization announced that the disease caused by the severe acute respiratory syndrome coronavirus 2 virus be called “corona virus disease 2019 (COVID-19).” Since the beginning of the pandemic there has been quite some debate regarding starting or continuing the treatment of diseases requiring immunosuppression. The major issues arise with management of dermatological diseases, such as vesiculobullous disorders, moderate-to-severe psoriasis, acute severe drug reactions, and connective tissue diseases which would require high level of immune-suppression or immune-modulation as treatment. In this article, we discuss the management strategies adopted for the management of pemphigus vulgaris (PV) and bullous pemphigoid (BP) as the prototypical examples. We will discuss the algorithm we evolved in our department for managing such cases during COVID-19 pandemic to give optimum benefit for our patients along with decreasing their risk for increased vulnerability for severe COVID-19 infection. The same principle can be used for other diseases requiring immunosuppressive or immunomodulatory therapies.

Objectives:

The management of the patients suffering from BP and PV that came to our department during the national lockdown during COVID-19 pandemic.

Materials and Methods:

It was a prospective study of 30 consecutive patients that came to our outpatient department either previously diagnosed or as fresh cases of PV or BP.

Results:

Treating patients with BP or PV during the pandemic has been a challenge. Analyzing the risk versus benefit and making a custom-based treatment helped us minimize the risk for severe COVID-19 infection as well as the side effects due to the primary drugs that are used in BP/PV. We were successful in keeping the primary disease in control. None of our patients was infected with symptomatic COVID-19 infection.

Conclusion:

With rapidly changing scenario of the pandemic it is very difficult to assess the optimal management of complex diseases such as PV and BP. With contradictory data available whether suppressing the immunity will result in a milder form of COVID 19 with less complications or render the patient at higher risk of complicated COVID-19 is unknown. Thus we, as dermato-physicians, need to keep ourselves and our patients updated, educated, and choose the best possible option where in the risk for severe COVID-19 infection minimized while keeping their primary disease in control.
Scar Sarcoidosis
Authors: Rani Seema , Singh Sweta , Bhardwaj Minakshi
Published: February 2021

Cutaneous sarcoidosis has varied clinical presentation and is a great mimicker, which requires an initial work-up for systemic involvement, followed by periodic screening. Recognition of cutaneous lesions is important because they provide a visible clue to the diagnosis and serve as an easily accessible source of tissue for histologic examination. Scar sarcoidosis is a rare clinical entity and often missed, and clinical diagnosis is made on subsequent biopsy after excluding other causes. We report a rare presentation of cutaneous sarcoidosis.
A Case of Lichen Planus Pigmentosus in Blaschkoid Pattern in a 10-Year-Old Female
Authors: Rai Tulika , Bohara Ayushi , Jha Prasanna Kumar
Published: February 2021

We describe a rare case of lichen planus pigmentosus (LPP) involving a 10-year-old female child with the involvement of the anterolateral aspect of the left thigh following the lines of Blaschko. LPP is a rare pigmented variant of lichen planus. Lines of Blaschko are lines of normal cell development. Histopathology showed melanophages in the papillary dermis with perivascular lymphocytic infiltrate and focal vacuolar change in basal layer consistent with a diagnosis of LPP.
Treatment for Syphilis Unraveling Gluten-Sensitive Linear IgA Dermatosis
Authors: Patel Ani Prakashbhai , Padhiyar Jignaben Krunal , Chandibhamar Vidhi Sanjay , Patel Nayankumar Harshadkumar
Published: February 2021

Linear IgA bullous dermatosis (LAD) is an acquired autoimmune blistering disorder which can develop following various drugs but not after banzathine penicillin injection. LAD has lower prevalence of associated gluten-sensitive enteropathy (GSE). We describe the case of a 20-year-old male with homosexual behavior who presented with multiple pruritic maculopapular lesions over the trunk, extremities, and palms for 2 months. Rapid plasma reagin (1:1280 titer) and treponema pallidum hemeagglutination tests were positive. A diagnosis of syphilis was made. The patient developed vesicular lesions following benzathine penicillin injection with histopathological and immunofluorescent features characteristic of LAD. Despite treatment, the patient continued developing new vesicles. Gluten-free diet (GFD) was advised, and the patient was further investigated for GSE. The patient responded well to GFD. We conclude that the prevalence of drug-induced LAD and associated GSE is quite low, but possibility exists. Hence, a diagnosis of GSE must be sought as patients might respond to GFD.
Comparison of Purified Protein Derivative and Vitamin D in the Treatment of Recalcitrant Warts
Authors: Raveendra Leena , Raju Belliappa Pemmanda , C Dharam Kumar KC , Kumar Yadav Vinutha Mohan
Published: February 2021

Background:

Viral warts are caused by human papillomavirus. There are various treatment modalities which cause destruction of the warts. Not all of them are very effective on difficult-to-treat warts. For the treatment of difficult-to-treat warts, new and effective treatment includes intralesional immunotherapy.

Objectives:

The aim was to evaluate and compare the efficacy of intralesional Vitamin D and tuberculin purified protein derivative (PPD) as immunotherapy in difficult-to-treat warts.

Materials and Methods:

A total of 100 patients with difficult-to-treat viral warts were enrolled in this randomized controlled study. Group A patients were injected intralesionally with 2.5 TU of tuberculin PPD (0.1 ml) and Group B patients were injected with 0.1 ml of Vitamin D3 per lesion to a maximum of ten lesions. The clinical assessment was done by photographic measurements at baseline, before each treatment session, and after the completion of the treatment every 2 weeks for a total of four sessions. Unpaired t-test was used to compare both the treatment modalities.

Results:

In Group A, a total of 38 (76%) patients showed complete clearance and 12 (24%) showed partial response, while in Group B, a total of 42 (84%) patients showed complete clearance, while 8 (16%) showed partial response. There was no statistically significant difference between both the modalities.

Conclusions:

Intralesional Vitamin D3 injection and intralesional PPD may be a treatment option for difficult-to-treat warts that are unresponsive to conventional treatments. Both are equally effective with minimal side effects.
Hair Loss Severity and its Impact on Quality of Life in Patients Suffering from Androgenic Alopecia
Authors: Lohia Kriti , Doshi Bhavana Ravindra , Manjunathswamy BS
Published: February 2021

Background:

Androgenic alopecia (AGA) is a common form of nonscarring alopecia encountered in daily dermatology practice. Both apparent and imperceptible AGA has a significant impact on an individual's personality, where physical appearance plays an important role in the probable prospects for marriage as well as other social aspects. Hair loss, thus, can severely hamper them for both men and women with clinical severity of alopecia not necessarily correlating with the quality of life (QoL) of the patient.

Objectives:

The objective is to assess the QoL in patients with AGA attending a tertiary care hospital in western India and compare QoL with hair loss severity (HLS), rated by both dermatologist and patient.

Materials and Methods:

One hundred and four patients, clinically diagnosed with AGA, consenting for the study over a period of 1 year were included. Demographic data of the patients were recorded. QoL was assessed using skindex-16 questionnaire; HLS was assessed through self-administered questionnaires completed by patients and dermatologists. Data were analyzed using Wilcoxon signed-rank test, Kendall's tau correlation coefficients, and Chi-square test.

Results:

The mean global score of Skindex–16 was 45.75 ± 16.90, with highest scores from emotions (64.93 ± 23.26). A positive correlation was found between the patients' HLS rating (r = 0.33, P < 0.0001) and the clinical HLS rating. However, patient rated the extent of their hair loss as more severe than the dermatologist. Patient-related HLS significantly correlated with the mean global score of Skindex–16 (P < 0.0001) as well as with all the subdomain scores (P < 0.0001), whereas dermatologist-rated HLS only significantly correlated with the global score of Skindex–16 (P = 0.04) but not with the subdomain scores.

Limitations:

As Skindex-16 is a self-reported questionnaire, there may be a recall bias. Another limitation of our study is the sample size; a study with a bigger sample size is required to vindicate our findings.

Conclusion:

The study demonstrates that AGA patients perceived their HLS as more severe than the dermatologist. Both patient-related HLS and dermatologist-rated HLS showed statistical correlation with the total global Skindex-16 score. Hence, dermatologists need to be more alert and should address the psychosocial and QOL issues, when treating patients with AGA.
Teledermatology During COVID Era
Authors: Doddaballapur Satish A , Bangera Amrutha N , Kaujalgi Radhika V , Dongare Aparna A
Published: February 2021

Background:

Telemedicine refers to “remote diagnosis and treatment of patients by means of telecommunication technology.” Dermatology has a unique place in telemedicine as a reasonably accurate diagnosis can be established by history, clinical images, and real-time video consultation.

Objectives:

The aim was to assess the merits and demerits of teleconsultation in the period of lockdown due to COVID-19.

Materials and Methods:

An analysis of data of teleconsultation done in 84 patients between April 08, 2020 and May 19, 2020 was assessed.

Results:

The age group of patients ranged from 1 month to 95 years, with a preponderance of females over males. The most common skin condition in the study was eczema, followed by acne, psoriasis, and vitiligo. Among the total 84 patients, three patients were called for in-person consultation to eliminate the margin of error and six patients voluntarily reported for the follow-up to the clinic.

Conclusion:

Teledermatology during the COVID era safeguards both patients and health-care workers from exposure to the virus. Although faced with several challenges, teleconsultation when judiciously used can be a boon in the diagnosis of dermatological disorders, especially in susceptible individuals.
Serum Biomarkers of Vitiligo
Authors: ElGhareeb Mohamed Ibrahim
Published: February 2021

The pathogenesis of vitiligo is complex, although the driving factors seem to become gradually clarified. This may help to identify possible targets for both detection of activity as well as discovering new therapeutic agents. In the coming years, new clinical trials are expected based on this scientific progress. Logically, a biomarker that allows an early and accurate determination of treatment response will also be of a considerable value. In contrast to other inflammatory skin disorders such as psoriasis or atopic dermatitis, vitiligo lacks obvious inflammatory signs, which can be easily evaluated by clinical examination. Several clinical activity signs have been described in vitiligo (such as hypochromic areas, blurred borders and confetti-like depigmentation, and Koebners' phenomenon), although these signs are only present in a subset of active vitiligo patients. Moreover, it is unclear whether these signs can be used to evaluate disease activity over time. The hallmark of vitiligo is its unpredictable clinical course, including periods of disease stability and disease flares. This complicates the daily management of vitiligo. Biomarker analysis could be useful to follow patients over time and even predict the chance of future disease progression, allowing to tailor the treatment to the individual biomarker profile.
Centrum handlowe a rzeka. Studium przypadku
Authors: Łabuz Rita
Published: February 2021

Rivers together with the surrounding greenery constitute an important element of the green and blue infrastructure in the city. The protection of these natural ecological corridors is one of the tasks of modern spatial planning. Along with the development of cities, buildings in urban areas are becoming closer to river beds. Various types of facilities are erected in their surroundings, including large-area constructions, such as shopping centres. This article presents research on how the watercourse environment is transformed by building a shopping centre. The paper presents functional and spatial analyses of riverside areas located in the vicinity of three shopping centres in Central Europe: ‘Forum Gdańsk’ in Gdańsk, ‘Galeria Jurajska’ in Częstochowa and ‘Šantovka’ in Olomouc. Various aspects of some transformations are presented, consisting in the exploitation of the advantages of natural greenery or its marginalisation, e.g. by backfilling or the housing of watercourses.
Michał Kaczkowski i jego praca O chorobie cholera morbus zwanej
Authors: Turos Maria Joanna
Published: February 2021

The appearance of cholera in Poland was a signifi cant epidemiological problem. One of the fi rst works devoted to the etiology, the search for methods of therapy as well as the necessary hygienic and sanitary measures to prevent the spread of this disease was written in 1830 by Michał Kaczkowski. His work, despite the passage of years, still deserves attention.
Problemy utrzymania zdrowia i kondycji fizycznej w świetle regulaminów wojskowych doby stanisławowskiej (zarys problematyki)
Authors: Cholewiński Łukasz
Published: February 2021

The text concerns the legal regulations on the maintenance of physical condition by soldiers in the Polish-Lithuanian Commonwealth in the second half of the 18th century, which until now in historiography were on the margins of interest of military historians. Meanwhile, the issues of feeding, foraging horses, housing quarters of soldiers, the availability of stables for animals or problems related to maintaining health affecting the maintenance of health and good physical condition seem extremely important in the research on the Crown Army of King Stanisław August. The article refers to the provisions contained in two regulations. In 1775, regulations of camp and garrison service for cavalry regiments were issued by hetman Franciszek Ksawery Branicki. Among other things, it specifi es how the army should leave the camp, how the march should proceed, and how the newly founded camp should look. The issue of foraging was regulated and attention was paid to the proper behavior of soldiers in the quarters. Instructions were also issued regarding the establishment and maintenance of feldspar and fi eld hospital. Second regulations, camp and garrison services issued for the whole army, sent out. He discussed in detail the issues related to camp service and everyday life in the garrison. The guidelines of both regulations were compiled in the text with source material from individual units of the Crown Army. This allows you to answer the question whether the regulations were followed by soldiers.
Architektura uczelni wyższych. Wybrane kryteria jakościowe przestrzeni współczesnego kampusu w badaniach i projektach studentów Wydziału Architektury Politechniki Śląskiej
Authors: Winnicka-Jasłowska Dorota
Published: February 2021

The education of architects at the Faculty of Architecture of the Silesian University of Technology in the field of architectural design is based on scientific research. Researchbased design means asking research questions and formulating answers supported by research methods that students learn during the course of their studies. The paper discusses a student didactic and research project carried out as a part of a semester course. The research concerned the evaluation of the functional, behavioural and organizational criteria indicated on the University campus, carried out using the Post-Occupancy Evaluation method (POE). The scope of the research included the following criteria: way-finding and buildings visual identification, universal design, services on the campus, network of learning and social contact places, design out crime issues, aesthetics of the university campus, and the campus as a space for social integration. The final part of the paper also presents selected student projects carried out on the basis of conclusions from the described research.
Ocena jakości przestrzeni publicznych III Kampusu UJ z użyciem techniki crowdsensingu
Authors: Działek Jarosław , Homiński BartłomieJ , Miśkowiec Magdalena , Świgost-Kapocsi Agnieszka , Gwosdz Krzysztof
Published: February 2021

The article aims to assess the quality of public spaces of the Third Campus of the Jagiellonian University and to determine to what extent the mobile crowdsensing survey method is useful in this respect. Public spaces are nowadays considered the key elements of the university campus structure. Their appropriate shaping and management fosters social interactions between different user groups, which should consequently strengthen creativity and interdisciplinarity within the university milieu. Our paper presents contemporary trends in the campus planning and organisation. In the empirical part, the quality of selected public spaces (main avenue, squares and courtyards, and green areas) was determined based on the behaviour of campus users as observed by participants of the crowdsensing study. These results were confronted with the visual material and comments of the study participants, as well as with the expert assessment of the authors. In the final part, activities aimed at improving the quality of public spaces of the campus were proposed.
Zagospodarowanie przestrzeni kampusu uniwersyteckiego z perspektywy studentów
Authors: Konior Agnieszka , Pokojska Weronika
Published: February 2021

The article concerns one of the basic groups of stakeholders on university campuses: students. Theoretical issues related to planning of public spaces, including university campuses, will be discussed, with particular emphasis on socializing the planning process and organization of socio-cultural events. The results of research conducted among students of culture and media management (Institute of Culture of the Jagiellonian University) will be presented. The research was conducted as part of the subject Urban projects (formerly Project management in urban space) in 2017/2018–2019/2020. The students’ task was to develop an analysis of the Jagiellonian University campus space, with particular emphasis on the building of the Faculty of Management and Social Communication (in which they defined their strengths, weaknesses, opportunities and threats), defined the target group, and proposed actions that could improve the quality of public spaces on the Jagiellonian University Campus (implemented with low/high expenditure in the short/long term). The work was carried out in groups, in total more than 60 responses were collected. ‘Good practices’ in the field of socio-cultural student activities that liven up campus space (e.g. the Culture and Media Festival Polikultura in Krakow) will also be presented.
Poder de compra del estado capitalista y financiación competitiva de la I+D. Un análisis marxiano de la transformación de la estructura económica de la producción científica
Authors: Arboledas-Lérida Luis
Published: February 2021

El presente artículo aborda la transformación de la estructura económica de la ciencia que viene acaeciendo desde los años ’80 del siglo pasado,a partir de los postulados desarrollados por Rosa Luxemburgo respecto del contradictorio movimiento expansivo de la relación social capitalista (acumulación del capital) y el papel desempeñado en el mismo por la demanda estatal. En concreto, se pretende demostrar que los cambios ocurridos en los últimos tiempos en materia de financiación de la denominada «ciencia pública» responden a la progresiva subsunción de esta esfera de la producción social a la lógica del valor; y que la demanda estatal, como momento particular de la acción del Estado capitalista, media necesariamente este despliegue de la forma capitalistas de producción al interior del ámbito de la academia.
Amedeo G. Conte: reglas constitutivas, validez deóntica, semiótica normativa
Authors: Alarcón-Cabrera Carlos
Published: February 2021

Se lleva a cabo un recorrido analítico del pensamiento filosófico de Amedeo Conte, filósofo del derecho recientemente fallecido. Conte es el discípulo de Bobbio que de un modo más certero profundizó en el estudio del impacto de la filosofía analítica en el universo normativo. Lo hizo a partir de los principales conceptos avanzados por Ludwig Wittgenstein, desarrollados a su vez por el discípulo, albacea y sucesor de éste, Georg H. von Wright, autor del principal sistema estándar de lógica deóntica.
Política migratoria venezolana, una tradición de recepción. El caso de la inmigración española del siglo XX
Authors: Castro-Trujillo Johnny
Published: February 2021

El presente trabajo se realiza un análisis documental de política pública sobre la historia migratoria venezolana desde sus orígenes como república hasta finales del siglo XX, centrando su mirada en los procesos de inmigración europea que se produjeron durante el siglo XX y en especial la inmigración española. Según la estadística fue la más numerosa dentro de los migrantes europeos que llegaron a Venezuela, y por el hecho de Venezuela haber recibido el 52% de toda la emigración española dirigida a América. Esto con el propósito de constatar que los programas y políticas inmigratorias constituyeron una política de Estado de aproximadamente ciento cincuenta años de experiencias de recepción, acogida e integración de migrantes en Venezuela.
Política, democracia y técnica en los modelos de gestión pública: el caso de la nueva gestión pública
Authors: Rodríguez-Fontenla Elena Rosalía
Published: February 2021

La actividad de la gestión pública suele contemplarse como antitética a la política y a la filosofía/teoría política. El caso de la Nueva GestiónPública nos ilustra el modo en el que las teorías de la gestión pública pueden recurrir al discurso de la racionalidad técnica y económica en aras de camuflar su contenido político y de alejarlo de la discusión pública. Argumentando que la técnica precisa de la política, revelamos la ideología política implícita en sus postulados de gestión. Finalmente, defendemos que las teorías de la gestión pública deberían ponderarse siempre desde los aportes normativos de la filosofía/teoría política.
A Qualitative Look at Leisure Benefits for Taiwanese Nursing Students
Authors: Hsieh Shwu-Ching , Spaulding Angela , Riney Mark
Published: February 2021

The purpose of this study was to determine attitudes of first year nursing students toward leisure participation at the Jen-Te Junior College of Medicine Nursing and Management in Miao-Li, Taiwan. The three research questions used for this study were: What types of leisure activities do first year nursing students at Jen-Te Junior College participate in?, what are the attitudes of first year nursing students at Jen-Te Junior College toward leisure?, and what is the relationship between leisure attitudes and leisure participation of first year nursing students in Jen-Te Junior College? The grounded theory method was used to generate the research findings. Five categories of students’ attitudes toward leisure emerged: social interaction, learning-seeking, psychological well-being, physical health and self-growth.
Threats and Aggression Directed at Soccer Referees: An Empirical Phenomenological Psychological Study
Authors: Friman Margareta , Nyberg Claes , Norlander Torsten
Published: February 2021

A descriptive qualitative analysis of in-depth interviews involving seven provincial Soccer Association referees was carried out in order to find out how referees experience threats and aggression directed to soccer referees. The Empirical Phenomenological Psychological method (EPP-method) was used. The analysis resulted in thirty categories which were summarized in six themes. The main themes described the perceived causes of threat, reactions to threat, how the referees manage stressful situations, and their motives to referee.
The Application of Interrater Reliability as a Solidification Instrument in a Phenomenological Study
Authors: Marques Joan , McCall Chester
Published: February 2021

Interrater reliability has thus far not been a common application in phenomenological studies. However, once the suggestion w a s brought up by a team of supervising professors during the preliminary orals of a phenomenological study, the utilization of this verification tool turned out to be vital to the credibility level of this type of inquiry, where the researcher is perceived as the main instrument and where bias may, hence, be difficult to eliminate. With creativeness and the appropriate calculation approach the researcher of the here reviewed qualitative study managed to apply this verification tool and found that the establishment of interrater reliability served as a great solidification to the research findings.
A Qualitative Examination of Mothers' Resolution or Non-Resolution of Their Childrens' Disability of Down Syndrome or Autism Using a Cognitive Intervention
Authors: Orme Denise
Published: February 2021

Research has shown that the inability of some mothers to resolve their emotions when confronted with the birth of a child with a disability of cerebral palsy or epilepsy can put the child at greater risk for disruptions of attachment. This qualitative study examined mothers' emotional state of resolution or non-resolution of their children's disability of Down syndrome or autism, and mothers' perceptions of the use of a cognitive intervention. Grounded theory was used to analyze the interviews and the cognitive intervention. The results showed that in addition to the two major categories of resolution and non-resolution, a third major category called “resolving” emerged from the data. New subcategories were discovered, and parts of the cognitive intervention were helpful.