bluuebunny/crossref_metadata_2025 huggingface dataset:
Pollution Sources Reconstruction Based on the Topological Derivative Method
Authors: Fernandez L. , Novotny A. A. , Prakash R. , Sokołowski J.
Published: April 2020

The topological derivative method is used to solve a pollution sources reconstruction problem governed by a steady-state convection-diffusion equation. To be more precise, we are dealing with a shape optimization problem which consists of reconstruction of a set of pollution sources in a fluid medium by measuring the concentration of the pollutants within some subregion of the reference domain. The shape functional measuring the misfit between the known data and solution of the state equation is minimized with respect to a set of ball-shaped geometrical subdomains representing the pollution sources. The necessary conditions for optimality are derived with the help of the topological derivative method which consists in expanding the shape functional asymptotically and then truncate it up to the second order term. The resulting expression is trivially minimized with respect to the parameters under consideration which leads to a noniterative second-order reconstruction algorithm. Two different cases are considered. Firstly, when the velocity of the leakages is given and we reconstruct the support of the unknown sources, including their locations and sizes. In the second case, we consider the size of the pollution sources to be known and find out the mean velocity of the leakages and their locations. Numerical examples are presented showing the capability of the proposed algorithm in reconstructing multiple pollution sources in both cases.
The influence of circulation weather types on the exposure of the biosphere to atmospheric electric fields
Authors: Kourtidis K. , Szabóné André K. , Karagioras A. , Nita I.-A. , Sátori G. , Bór J. , Kastelis N.
Published: April 2020

We present an analysis of the impact of circulation weather types (CT) on a factor that might influence biological systems and the human condition, the electric state of the atmosphere. We present results on the influence of CT to the magnitude, the direction (positive or negative), the fluctuation magnitude, and the short-term peaks of the atmospheric electric field (potential gradient, PG), using data from a station in Greece. CTs with high vorticity centers over Greece are associated with high positive and negative excursions of the PG, higher PG variability, and rain events. CTs with thinner 850–500 hPa layer are associated with higher daily mean values of fair-weather PG. We also examine the influence of CT on the frequency and amplitude of the naturally occurring extremely low-frequency electric field fluctuations known as Schumann resonances (SR) using data from a station in Hungary. The first and second mode SR frequencies are increased during CTs associated with higher 500 hPa geopotential heights and higher 850–500 hPa layer thickness. This hints to a lower-upper atmosphere coupling. So, CTs not only influence the general temperature and humidity conditions to which the biosphere is exposed, but they also affect its exposure to atmospheric electric fields.
Isolation and characterization of 2-butoxyethanol degrading bacterial strains
Authors: Woiski Christine , Dobslaw Daniel , Engesser Karl-Heinrich
Published: April 2020

A total of 11 bacterial strains capable of completely degrading 2-butoxyethanol (2-BE) were isolated from forest soil, a biotrickling filter, a bioscrubber, and activated sludge, and identified by 16S rRNA gene sequence analysis. Eight of these strains belong to the genus Pseudomonas; the remaining three strains are Hydrogenophaga pseudoflava BOE3, Gordonia terrae BOE5, and Cupriavidus oxalaticus BOE300. In addition to 2-BE, all isolated strains were able to grow on 2-ethoxyethanol and 2-propoxyethanol, ethanol, n-hexanol, ethyl acetate, 2-butoxyacetic acid (2-BAA), glyoxylic acid, and n-butanol. Apart from the only gram-positive strain isolated, BOE5, none of the strains were able to grow on the nonpolar ethers diethyl ether, di-n-butyl ether, n-butyl vinyl ether, and dibenzyl ether, as well as on 1-butoxy-2-propanol. Strains H. pseudoflava BOE3 and two of the isolated pseudomonads, Pseudomonas putida BOE100 and P. vancouverensis BOE200, were studied in more detail. The maximum growth rates of strains BOE3, BOE100, and BOE200 at 30 °C were 0.204 h−1 at 4 mM, 0.645 h−1 at 5 mM, and 0.395 h−1 at 6 mM 2-BE, respectively. 2-BAA, n-butanol, and butanoic acid were detected as potential metabolites during the degradation of 2-BE. These findings indicate that the degradation of 2-BE by the isolated gram-negative strains proceeds via oxidation to 2-BAA with subsequent cleavage of the ether bond yielding glyoxylate and n-butanol. Since Gordonia terrae BOE5 was the only strain able to degrade nonpolar ethers like diethyl ether, the degradation pathway of 2-BE may be different for this strain.
Rapid lipid bilayer membrane formation on Parylene coated apertures to perform ion channel analyses
Authors: Ahmed Tanzir , van den Driesche Sander , Bafna Jayesh Arun , Oellers Martin , Hemmler Roland , Gall Karsten , Wagner Richard , Winterhalter Mathias , Vellekoop Michael J.
Published: April 2020

We present a chip design allowing rapid and robust lipid bilayer (LBL) membrane formation using a Parylene coated thin silicon nitride aperture. After bilayer formation, single membrane channels can be reconstituted and characterized by electrophysiology. The ability for robust reconstitution will allow parallelization and enhanced screening of small molecule drugs acting on or permeating across the membrane channel. The aperture was realized on a microfabricated silicon nitride membrane by using standard clean-room fabrication processes. To ensure the lipid bilayer formation, the nitride membrane was coated with a hydrophobic and biocompatible Parylene layer. We tested both Parylene-C and Parylene-AF4. The contact angle measurements on both Parylene types showed very good hydrophobic properties and affinity to lipids. No precoating of the Parylene with an organic solvent is needed to make the aperture lipophilic, in contradiction to Teflon membranes. The chips can be easily placed in an array utilizing a 3D printed platform. Experiments show repetitive LBL formation and destruction (more than 6 times) within a very short time (few seconds). Through measurements we have established that the LBL layers are very thin. This allows the investigation of the fusion process of membrane proteins i.e. outer membrane protein (OmpF) in the LBL within a few minutes.
Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
Authors: Gómez-Acebo Inés , Dierssen-Sotos Trinidad , Palazuelos-Calderón Camilo , Pérez-Gómez Beatriz , Amiano Pilar , Guevara Marcela , Molina Antonio J. , Domingo Laia , Fernández-Ortiz María , Moreno Victor , Alguacil Juan , Fernández-Tardón Guillermo , Ibáñez Josefa , Marcos-Gragera Rafael , Diaz-Santos Marian , Alonso M. Henar , Alonso-Molero Jessica , Castaño-Vinyals Gemma , Palomo Andrés García , Ardanaz Eva , Molinuevo Amaia , Aragonés Nuria , Kogevinas Manolis , Pollán Marina , Llorca Javier
Published: April 2020

Purpose

The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score.

Methods

The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors.

Results

Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively.

Conclusion

Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased
Disease mapping of early- and late-stage cancer to monitor inequalities in early detection: a study of cutaneous malignant melanoma
Authors: Strömberg Ulf , Parkes Brandon L. , Holmén Anders , Peterson Stefan , Holmberg Erik , Baigi Amir , Piel Frédéric B.
Published: April 2020

We consider disease mapping of early- and late-stage cancer, in order to identify and monitor inequalities in early detection. Our method is demonstrated by mapping cancer incidence at high geographical resolution using data on 10,302 cutaneous malignant melanoma (CMM) cases within the 3.7 million population of South-West Sweden. The cases were geocoded into small-areas, each with a population size between 600 and 2600 and accessible socio-demographic data. Using the disease mapping application Rapid Inquiry Facility (RIF) 4.0, we produced regional maps to visualise spatial variations in stage I, II and III–IV CMM incidences, complemented by local maps to explore the variations within two urban areas. Pronounced spatial disparities in stage I CMM incidence were revealed by the regional and local maps. Stage I CMM incidence was markedly higher in wealthier small-areas, in particular within each urban area. A twofold higher stage I incidence was observed, on average, in the wealthiest small-areas (upper quintile) than in the poorest small-areas (lower quintile). We identified in the regional map of stage III–IV CMM two clusters of higher or lower than expected late-stage incidences which were quite distinct from those identified for stage I. In conclusion, our analysis of CMM incidences supported the use of this method of cancer stage incidence mapping for revealing geographical and socio-demographic disparities in cancer detection.
Sanitary condition and its microbiological quality of improved water sources in the Southern Region of Ethiopia
Authors: Alemayehu Tsigereda Assefa , Weldetinsae Abel , Dinssa Daniel Abera , Derra Firehiwot Abera , Bedada Tesfaye Legese , Asefa Yosef Beyene , Mengesha Sisay Derso , Alemu Zinabu Assefa , Serte Melaku Gizaw , Teklu Kirubel Tesfaye , Woldegabriel Mesay Getachew , Kenea Moa Abate , van den Berg Harold , de Roda Husman Ana Maria
Published: April 2020

In the Southern Nations, Nationalities, and Peoples’ Region of Ethiopia, improved water is the main source of water for household purposes. Access to improved water closer to their homes benefits the community in many ways. It improves their health status, saves their time and energy, and improves their productivity in jobs and education they are engaged in. However, due to natural and human activities, improved water sources do not always deliver good quality of water. It can be contaminated by different pathogenic microorganisms and chemicals. The result indicated that 44.7% and 50.9% of the samples were contaminated with Escherichia coli and enterococci respectively, and from the sanitary condition survey, 57.6% of the water sources exhibited from intermediate- to very high-risk level. And the risk priority matrix identifies 95 (27.9%) samples with high risk and 54 (15.9%) of the samples with very high risk. The main risks identified at those unsafe water sources were that the drainage canals were blocked with mud, grass, leaves, and stones; animals drinking the overflow water and grazing in the proximity of water sources and feces such as cow dung were observed; inadequate protection of water sources such as absence of fences and diversion ditches; and stagnant water near the source. The study conducted in the Southern Nations, Nationalities, and Peoples’ Region has clearly indicated that people may be at risk of being exposed to pathogens in half of the improved water sources when used for drinking based on the microbial indicator data or the sanitary inspection risk score. Though no correlation resulted from water quality and sanitary condition of sources, the risk priority matrix did enable prioritization of 54 very high-risk-level water sources for urgent targeted interventions from a total of 340 improved drinking water sources. From this, targeted interventions, improving water management practices, identifying and implementing effective water treatment options, providing sustainable energy sources for the supply of continuous water, and implementing climate resilience water safety planning, are recommended.
Development of the Observation Schedule for Children with Autism–Anxiety, Behaviour and Parenting (OSCA–ABP): A New Measure of Child and Parenting Behavior for Use with Young Autistic Children
Authors: Palmer Melanie , Paris Perez Juan , Tarver Joanne , Cawthorne Thomas , Frayne Margot , Webb Sophie , Baker Elena , Yorke Isabel , Hay Dale , Slonims Vicky , Pickles Andrew , Simonoff Emily , Scott Stephen , Charman Tony
Published: April 2020

Co-occurring emotional and behavioral problems (EBPs) frequently exist in young autistic children. There is evidence based on parental report that parenting interventions reduce child EBPs. More objective measures of child EBPs should supplement parent reported outcomes in trials. We describe the development of a new measure of child and parenting behavior, the Observation Schedule for Children with Autism–Anxiety, Behaviour and Parenting (OSCA–ABP). Participants were 83 parents/carers and their 4–8-year-old autistic children. The measure demonstrated good variance and potential sensitivity to change. Child and parenting behavior were reliably coded among verbal and minimally verbal children. Associations between reports from other informants and observed behavior showed the measure had sufficient convergent validity. The measure has promise to contribute to research and clinical practice in autism mental health beyond objective measurement in trials.
Adenosine usage during AF ablation in Europe and selected long-term findings from the ESC-EHRA EORP Atrial Fibrillation Ablation Long-Term registry
Authors:   on behalf of the ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators, van Rosmalen Frank , Delhaas Tammo , Dagres Nikolaos , Arbelo Elena , Blomström-Lundqvist Carina , Crijns Harry J. G. M. , Da Costa Antoine , Pytkowski Mariusz , Sharikov Nikita , Laroche Cécile , Tavazzi Luigi , Brugada Joseph , Pison Laurent
Published: April 2020

Background

Adenosine can be used to reveal dormant pulmonary vein (PV) conduction after PV isolation (PVI). This study presents a subanalysis of real-world 1-year follow-up data from the ESC-EHRA EORP Atrial Fibrillation (AF) Ablation Long-Term registry to analyze the usage of adenosine during PVI treatment in terms of rhythm outcome and safety.

Methods

The registry consists of 104 participating centers in 27 countries within the European Society of Cardiology. The registry data was split into an adenosine group (AG) and no-adenosine group (NAG). Procedure characteristics and patient outcome were compared.

Results

Adenosine was administered in 10.8% of the 3591 PVI patients included in the registry. Spain, the Netherlands, and Italy included the majority of adenosine cases (48.8%). Adenosine was applied more often in combination with open irrigation radiofrequency (RF) energy (74.7%) and less often in combination with nonirrigated RF energy (1.6%). After 1 year, a higher percentage of the AG was free from AF compared with the NAG (68.9% vs 59.1%, p < 0.001). Adenosine was associated with better rhythm outcome in RF ablation procedures, but not in cryo-ablation procedures (freedom from AF: RF: AG: 70.9%, NAG: 58.1%, p < 0.001, cryo: AG: 63.9%, NAG: 63.8%, p = 0.991).

Conclusions

The use of adenosine was associated with a better rhythm outcome after 1 year follow-up and seems more useful in patients treated with RF energy compared with patients treated with cryo energy. Given the improved rhythm outcome at 1-year follow-up, it seems reasonable to encourage the use of adenosine during RF AF ablation.
Experimental study of the Al–Cu–Zn ternary phase diagram
Authors: Zobac Ondrej , Kroupa Ales , Richter Klaus W.
Published: April 2020

The phase diagram of the Al–Cu–Zn ternary system was re-investigated experimentally. The current study was designed to contribute to a better description of those parts of the phase diagram, which are disputed in the current scientific literature. Mutual relations in the family of ternary intermetallic phases τ with cubic, rhombohedral and modulated structure at temperatures 400 °C and 550 °C were described. The phase relation between the γ and γ′ phases was studied at different temperatures. A two-phase field between γ and γ′ was observed below 400 °C, while the transition appears to be second order at higher temperatures. A vertical section between γ and γ′ phases in Cu–Zn and Al–Cu and four isothermal sections at 400 °C, 550 °C, 700 °C and 820 °C, respectively, were constructed.
Renormalizing the Kardar–Parisi–Zhang Equation in $$d\ge 3$$ in Weak Disorder
Authors: Comets Francis , Cosco Clément , Mukherjee Chiranjib
Published: April 2020

We study Kardar–Parisi–Zhang equation in spatial dimension 3 or larger driven by a Gaussian space–time white noise with a small convolution in space. When the noise intensity is small, it is known that the solutions converge to a random limit as the smoothing parameter is turned off. We identify this limit, in the case of general initial conditions ranging from flat to droplet. We provide strong approximations of the solution which obey exactly the limit law. We prove that this limit has sub-Gaussian lower tails, implying existence of all negative (and positive) moments.
The Co-development and Feasibility-Testing of an Innovative Digital Animation Intervention (DAISI) to Reduce the Risk of Maternal Sepsis in the Postnatal Period
Authors: Haith-Cooper Melanie , Stacey Tomasina , Bailey Fran , Broadhead-Croft Sarah
Published: April 2020

Introduction

Sepsis is one of the most common causes of mortality in postnatal women globally and many other women who develop sepsis are left with severe morbidity. Women’s knowledge of postnatal sepsis and how it can be prevented by simple changes to behaviour is lacking.

Methods

This paper describes the co-development and feasibility testing of a digital animation intervention called DAISI (digital animation in service improvement). This DAISI is designed to enhance postnatal women’s awareness of sepsis and how to reduce their risk of developing the condition. We co-designed the digital animation over a six-month period underpinned by theory, best evidence and key stakeholders, translated it into Urdu then assessed its use, firstly in a focus group with women from different Black, Asian and Minority Ethnic (BAME) groups and secondly with 15 clinical midwives and 15 women (including BAME women). Following exposure to the intervention, midwives completed a questionnaire developed from the COM-B behaviour change model and women participated in individual and focus group interviews using similar questions.

Results

The animation was considered acceptable, culturally sensitive and simple to implement and follow.

Discussion

DAISI appears to be an innovative solution for use in maternity care to address difficulties with the postnatal hospital discharge process. We could find no evidence of digital animation being used in this context and recommend a study to test it in practice prior to adopting its use more widely. If effective, the DAISI principle could be used in other maternity contexts and other areas of the NHS to communicate health promotion information.
Quality of life in women with endometriosis: a cross-sectional survey
Authors: Bień Agnieszka , Rzońca Ewa , Zarajczyk Marta , Wilkosz Katarzyna , Wdowiak Artur , Iwanowicz-Palus Grażyna
Published: April 2020

Purpose

The aim of the study was to assess QoL and identify and analyse its determinants in women with endometriosis.

Methods

The study was performed in 2019 in health centres in Lublin (Poland) on 309 women with diagnosed endometriosis. In order to verify which factors affect QoL of the study participants, regression for qualitative variables (CATREG) was used. The applied research instruments included the WHOQOL-BREF quality of life questionnaire, the Acceptance of Illness Scale (AIS), the Laitinen Pain Scale, and a general questionnaire.

Results

The overall QoL score of the respondents was 3.30, whereas their overall perceived health score was 2.37. The highest QoL scores were found for the psychological domain 13.33, whereas the lowest QoL were found for the physical domain 11.52. Women with endometriosis have a moderate level of illness acceptance (24.64) and experience daily pain of moderate intensity (5.83).

Conclusion

Women with endometriosis rate their overall QoL higher than their overall perceived health. Perceived QoL in women with endometriosis is most commonly associated with their acceptance of illness, BMI, negative impact of symptoms on the relationship with the partner, and dyspareunia. To improve these women’s lives, care should also respond to the social, emotional, and sexual issues resulting from the illness. Such interventions will contribute to improved comfort and QoL among these women.
Proficiency level descriptors for low reading proficiency: An integrative process model
Authors: Durda Tabea , Artelt Cordula , Lechner Clemens M. , Rammstedt Beatrice , Wicht Alexandra
Published: April 2020

Low literacy among adolescents and adults worldwide remains a serious problem, even in economically developed countries. The consequences of low reading proficiency levels can be harmful in many ways for both the individuals concerned and their communities in terms of health, political, social and economic outcomes. While large-scale international assessments do assess reading proficiency, the data they provide for the bottom end of the scale are still somewhat undifferentiated. What is of particular concern to scholars and policymakers alike is to better understand the nature of reading difficulties among low-literate adolescents and adults. Addressing this need, the authors of this article present a new integrative process model which takes into consideration reader-related, text-related and task-related factors along different stages of the reading process that can cause reading difficulties. The process model incorporates different traditions of research on low reading proficiency: large-scale assessments, cognitive psychology, and research on developmental precursors of reading comprehension. It enabled the authors to identify core difficulty-generating factors, in particular task and text characteristics relevant in evaluating the difficulty of a reading task and thus in determining whether low-literate readers can solve it. The process model also proved suitable for incorporation into standard-setting practice. The authors demonstrate how the process model provided a framework for developing proficiency level descriptors (PLDs) which were then applied for the purpose of standard setting in a German large-scale assessment, the National Educational Panel Study (NEPS). Their results show that the PLDs were indeed suitable for differentiating between a low reading proficiency level and a functional reading proficiency level among adolescents and adults.
Linking Human Development and the Financial Responsibility of Regions: Combined Index Proposals Using Methods from Data Envelopment Analysis
Authors: Ferraz Diogo , Mariano Enzo B. , Rebelatto Daisy , Hartmann Dominik
Published: April 2020

Several indicators on human development and capabilities have been introduced in recent decades that measure the absolute level of deprivations and freedoms of people. However, these indicators typically do not consider to what extent regions and countries efficiently spend their limited financial resources on improving human development. This is an important shortcoming because regions typically face different financial constraints in developing social policies and promoting human development. In this article, we advance methods from data envelopment analysis (DEA) to measure absolute capability values and the social efficiency of 129 Brazilian mesoregions. We present a new indicator called theCapability Index Adjusted by Social Efficiency (CIASE)that evaluates the human development performance of regions based on their absolute levels of deprivations as well as their social efficiency in translating limited financial resources into human development. Moreover, we introduce aDeprivation and Financial Responsibility based Prioritization Index (DFRP)that helps to identify priority regions for higher public expenditures in human development. Our results for the case of Brazil show that several poor regions perform relatively better in terms of social efficiency than in terms of absolute human development. Conversely, several rich regions perform relatively worse in terms of social efficiency than in absolute values. Thus, our analysis shows how DEA methods can help to bridge perspectives that are often presented as separated issues but could be strong allies for development: attending to human deprivation and promoting social efficiency.
Sequencing of two transgenic early-flowering poplar lines confirmed vector-free single-locus T-DNA integration
Authors: Kersten Birgit , Leite Montalvão Ana Paula , Hoenicka Hans , Vettori Cristina , Paffetti Donatella , Fladung Matthias
Published: April 2020

Next-generation sequencing (NGS) approaches are attractive alternatives to the PCR-based characterisation of genetically modified plants for safety assessment and labelling since NGS is highly sensitive to the detection of T-DNA inserts as well as vector backbone sequences in transgenic plants. In this study, two independent transgenic male Populus tremula lines, T193-2 and T195-1, both carrying the FLOWERING LOCUS T gene from Arabidopsis thaliana under control of a heat-inducible promoter (pHSP::AtFT) and the non-transgenic control clone W52, were further characterised by NGS and third-generation sequencing. The results support previous findings that the T-DNA was hemizygously inserted in one genomic locus of each line. However, the T-DNA insertions consist of conglomerations of one or two T-DNA copies together with a small T-DNA fragment without AtFT parts. Based on NGS data, no additional T-DNA splinters or vector backbone sequences could be identified in the genome of the two transgenic lines. Seedlings derived from crosses between the pHSP::AtFT transgenic male parents and female wild type plants are therefore expected to be T-DNA splinter or vector backbone free. Thus, PCR analyses amplifying a partial T-DNA fragment with AtFT-specific primers are sufficient to determine whether the seedlings are transgenic or not. An analysis of 72 second generation-seedlings clearly showed that about 50% of them still reveal the presence of the T-DNA, confirming data already published. To prove if unanticipated genomic changes were induced by T-DNA integration, extended future studies using long-range sequencing technologies are required once a suitable chromosome-level P. tremula reference genome sequence is available.
The short-term effects of air pollution on respiratory disease hospitalizations in 5 cities in Poland: comparison of time-series and case-crossover analyses
Authors: Slama Alessandro , Śliwczyński Andrzej , Woźnica-Pyzikiewicz Jolanta , Zdrolik Maciej , Wiśnicki Bartłomiej , Kubajek Jakub , Turżańska-Wieczorek Olga , Studnicki Marcin , Wierzba Waldemar , Franek Edward
Published: April 2020

Very few publications have compared different study designs investigating the short-term effects of air pollutants on healthcare visits and hospitalizations for respiratory tract diseases. This study describes, using two different study designs (a case-crossover design and a time-series analysis), the association of air pollutants and respiratory disease hospitalizations. The study has been conducted on 5 cities in Poland on a timeline of almost 4 years. DLNM and regression models were both used for the assessment of the short-term effects of air pollution peaks on respiratory hospitalizations. Both case-crossover and time-series studies equally revealed a positive association between air pollution peaks and hospitalization occurrences. Results were provided in the form of percentage increase of a respiratory visit/hospitalization, for each 10-μg/m3 increment in single pollutant level for both study designs. The most significant estimated % increases of hospitalizations linked to increase of 10 μg/m3 of pollutant have been recorded in general with particulate matter, with highest values for 24 h PM2.5 in Warsaw (6.4%, case-crossover; 4.5%, time series, respectively) and in Białystok (5.6%, case-crossover; 4.5%, time series, respectively). The case-crossover analysis results have shown a larger CI in comparison to the results of the time-series analysis, while the lag days were easier to identify with the case-crossover design. The trends and the overlap of the results occurring from both methods are good and show applicability of both study designs to air pollution effects on short-term hospitalizations.
Effects of prenatal exposure to NO2 on children’s neurodevelopment: a systematic review and meta-analysis
Authors: Shang Li , Yang Liren , Yang Wenfang , Huang Liyan , Qi Cuifang , Yang Zixuan , Fu Zhuxuan , Chung Mei Chun
Published: April 2020

The neurotoxicity of NO2 exposure is well-known and potentially causes impaired of neural functions. This review aimed to estimate associations between prenatal NO2 exposure and neurodevelopment for children. Articles published until May 2019 reported prenatal NO2 exposure and children’s cognition, psychomotor, language, attention, IQ, and behavior function were searched according to all related terms. The main databases we retrieved included PubMed, Web of Science, Embase, and Cochrane Library. Coefficient was extracted, conversed, and synthesized by random effects meta-analysis. Meanwhile, qualitatively describe would be used for some studies which cannot be synthesized quantitatively for lack of quantity or methods inconsistency. Finally, a total of 3848 citations were searched, and only 10 studies were included. We estimated that per 10 μg/m3 increase of NO2 during pregnancy was associated with a − 0.76 point decrease in global psychomotor (95% CI, − 1.34, − 0.18) and a − 0.62 point decrease in fine psychomotor for children (95% CI, − 1.09, − 0.16). But no significant association found in general cognitive and language. In addition, through the literature review, it seemed that prenatal exposure to NO2 might cause adverse impacts on children’s attention, IQ, and different behaviors, but this requires confirmation from further researches. Our study indicated that prenatal exposure to NO2 seems to be associated with impaired neural development for children, especially for fine psychomotor. However, further studies are needed for determining the effects of prenatal air pollution exposure on attention, IQ, and behavior.
Learning as a key leverage point for sustainability transformations: a case study of a local government in Perth, Western Australia
Authors: Bryant Jayne , Thomson Giles
Published: April 2020

This paper presents a case study about embedding sustainability into a local government in Perth, Western Australia, through the introduction of a sustainability policy and the accompanying education and culture change program. This longitudinal case study describes the approach and impact of the program initiated and delivered by internal officers between 2011 and 2016. The use of personal experience, document review and staff interviews present an ethnography of a bureaucracy that casts some light upon the seldom seen inner workings of a local government organisation as it introduced a sustainability program over a period of more than 5 years. The case study provides evidence of the potential power of learning as a key leverage point for transformational sustainability change.
Cloud computing ecosystem model: evaluation and role clusters
Authors: Floerecke Sebastian , Lehner Franz , Schweikl Sebastian
Published: April 2020

Several significantly different attempts have been undertaken to visualize the complex and opaque cloud computing ecosystem by a descriptive model. Recently, scholars have developed a new role-based cloud ecosystem model (PassauCloud ComputingEcosystem Model (PaCE model)) based on a systematic analysis and synthesis of the previous models. However, its scientific evaluation is still outstanding. The main goal is therefore to conduct an evaluation regarding its structural equivalence and completeness compared to the real cloud business according to the design science research paradigm. The second goal is to demonstrate the model’s usefulness by using it as an instrument for the identification of role clusters, which are frequently covered by organizations. To this end, a cross-sectional analysis is conducted, in which 758 organizations are manually analysed and matched with the model’s current roles. As a result, roles have been newly added, removed, broken down into sub-roles, abstracted to a meta-role and renamed. The cluster analysis unveiled five role clusters. Whereas some roles were predominantly found as single role, further roles were exclusively or very frequently found in combination with others. Overall, the revised model creates, compared to the common rather technically orientated market overviews by market research institutes, a detailed categorization schema helping to understand and investigate the organizations belonging to the cloud ecosystem.
Enhanced fuzzy finite state machine for human activity modelling and recognition
Authors: Mohmed Gadelhag , Lotfi Ahmad , Pourabdollah Amir
Published: April 2020

A challenging key aspect of modelling and recognising human activity is to design a model that can deal with the uncertainty in human behaviour. Several machine learning and deep learning techniques are employed to model the Activity of Daily Living (ADL) representing
the human activity. This paper proposes an enhanced Fuzzy Finite State Machine (FFSM) model by combining the classical FFSM with Long Short-Term Memory (LSTM) neural network and Convolutional Neural Network (CNN). The learning capability in the LSTM and CNN allows the system to learn the relationship in the temporal human activity data and to identify the parameters of the rule-based system as building blocks of the FFSM through time steps in the learning mode. The learned parameters are then used for generating the fuzzy rules that govern the transitions between the system’s states representing activities. The proposed enhanced FFSMs were tested and evaluated using two different datasets; a real dataset collected by our research group and a public dataset collected from CASAS smart home project. Using LSTM-FFSM, the experimental results achieved $$95.7\%$$

95.7
%

and $$97.6\%$$

97.6
%

for the first dataset and the second dataset, respectively. Once CNN-FFSM was applied to both datasets, the obtained results were $$94.2\%$$

94.2
%

and $$99.3\%$$

99.3
%

, respectively.
Nephroprotective effects of GLP-1 receptor agonists: where do we stand?
Authors: Mosterd Charlotte M. , Bjornstad Petter , van Raalte Daniël H.
Published: April 2020

Glucagon-like peptide (GLP)-1 receptor agonists are the cornerstone in the treatment of hyperglycemia in many people suffering from type 2 diabetes (T2D). These drugs have potent glucose-lowering actions and, additionally, lower body weight through satiety induction while reducing blood pressure and dyslipidemia. Partly through these actions, GLP-1 receptor agonism was shown to reduce cardiovascular disease (CVD) in people with T2D with previous CVD or at high-risk thereof. In these cardiovascular safety trials, in secondary or exploratory analyses, GLP-1 receptor agonists were also shown to reduce macro-albuminuria, an accepted surrogate marker for diabetic kidney disease (DKD), a condition that still represents a major unmet medical need. In this review we will discuss the evidence which suggests renoprotection induced by GLP-1 receptor agonists and the potential mechanisms that may be involved. These include mitigation of hyperglycemia, overweight and insulin resistance, systemic and glomerular hypertension, dyslipidemia, sodium retention, inflammation and renal hypoxia. The recently initiated large-sized FLOW trial investigating the effects of semaglutide on hard renal outcomes in patients with DKD will provide clarity whether GLP-1 receptor agonists may reduce the burden of DKD in addition to their other beneficial metabolic and cardiovascular effects.
Hematologist and transplant physicians
Authors: Dalle Jean-Hugues
Published: April 2020

Despite huge progress in the fields of newborn screening, encapsulated bacterial infection prophylaxis, immunization, and supportive care in general, people suffering from sickle cell anemia still continue to have a shorter life expectancy and a poorer quality of life due to painful vaso-occlusive events and strokes during childhood, and later, cardiac, pulmonary, and renal injuries, including in Western and high-income countries.

From the 2000s, allogeneic stem cell transplantation for severe sickle cell disease from a sibling donor provided the best results-overall as well as disease-free survival-never obtained for any other disease. Nevertheless, this only curative option is proposed to few patient numbers, including in Western countries with high-level medical equipment development, with discrepancies between (i) patients and family, (ii) physicians and care centers dedicated to sickle cell disease, and (iii) hematopoietic stem cell transplant teams.

Due to these discrepancies and in order to provide the same quality of discussion and treatment choice for every sickle cell disease patient, we developed a National French multidisciplinary pluri-annual meeting dedicated to sickle cell disease patients and transplantation. We report here our experience of such a meeting.
Practicing Mass Casualty Scenarios: Experience From a Developing Level 1 Trauma Center in the Himalayan Foothills
Authors: Azam Md Quamar , Devasthale Mahesh , B Chandu Raj , Kumar Ajay , Sarkar Bhaskar , Rattan Amulya
Published: April 2020

Objective:

Uttarakhand is an Indian state in the Himalayan foothills, a favored adventure destination in the country due to abundant natural beauty. However, the terrain has also conferred an increased risk of earthquakes, flash floods, and major road tragedies, resulting in as many as 8 major natural disasters in the state in the preceding 20 years. AIIMS Rishikesh, an autonomous central institute, has been entrusted to build a Level 1 Trauma Center in Uttarakhand, which would help improve the response, coordination, and hence outcome in mass casualty scenarios (MCSs).

Methods:

As a step toward the achievement of this larger goal, a workshop on MCS and management was conducted by the Department of Trauma Surgery in collaboration with Rambam Hospital, Haifa. We hereby present our template for conducting MCS drills in low resource settings like ours and the lessons learnt.

Results:

Process, logistics, limitations, workforce, scheduling, overview, and report of the MCS drill conducted are discussed hereafter.

Conclusion:

This template may be replicated by hospitals that intend to conduct similar MCS drills in low resource settings, realizing the real threat of MCS occurrence in our country at anytime.
Cultural safety training for allied health students in Australia
Authors: Gray Marion , Thomas Yvonne , Bonassi Marianne , Elston Jacinta , Tapia Geraldine
Published: April 2020

Abstract Culturally safe health practitioners are essential for effective service provision to culturally diverse populations, including Indigenous Australians. Therefore, cultural safety education during training as a health care professional is an essential component in helping improve the health of Indigenous Australians. This study examined whether the implementation of an Indigenous cultural safety education workshop increased self-rated cultural safety knowledge and attitudes of allied health students. The study employed a quantitative before-and-after design using pre- and post-surveys to determine the level of attitudinal change in students who attended a day long workshop. The study sample consisted of 1st year (n = 347) and 4th year (n = 149) allied health students at a regional Australian university over the years 2007–2011. Whilst the results of this current study are varied in terms of achieving positive change across all of the taught items of knowledge and attitude, they provide some evidence around the value of this type of curriculum intervention in helping develop culturally safe practitioners. An important finding was around the student's becoming self-aware about their own values and cultural identity, combined with acknowledging the importance of this cultural identity to interactions with clients. This form of ‘cultural humility’ appears to be an important step to becoming a culturally safe practitioner. These types of interventions would be enhanced through embedding and scaffolding throughout the curricula.
A Non-Classical Analytical Approach for Vibration Analysis of Isotropic and Fgm Plate Containing a Star Shaped Crack
Authors: Gupta Ankur , Soni Shashank , Jain N. K.
Published: April 2020

A non-classical analytical model for vibration analysis of thin isotropic and FGM plate containing multiple part-through cracks (star shaped) of arbitrary orientation is proposed. A plate containing four concentric cracks of arbitrary orientation in the form of continuous line is considered for analysis. The proposed governing equation is derived based on classical plate theory and modified couple stress theory. Line spring model is modified to accommodate all the crack terms. The application of Berger’s formulation introduces nonlinearities in the governing equation and then the Galerkin’s method is applied for solving final governing equation. Results for fundamental frequencies for different values of crack length, crack orientation, gradient index and material length scale parameters are presented for two different boundary conditions. Furthermore, to study the phenomenon of bending hardening/softening in a cracked plate, the frequency response curves are plotted for the parameters stated above. Based on the outcomes of this study, it can be concluded that stiffness of the plate is severely affected by the presence of multiple cracks and the stiffness goes on decreasing with increase in number of cracks thereby affecting the fundamental frequency.
Effect of Carbon Nanotubes’ Diameter on Freeze-Thaw Resistance of Cement Paste
Authors: Tian Wei , Gao Fangfang
Published: April 2020

This paper aims to investigate the freeze-thaw resistance of cement-paste containing with different diameter and content of multiwalled carbon nanotubes (MWCNTs) in terms of mechanical properties and microstructure. Three groups of cement-paste with MWCNTs diameter of 10-20 nm, 20-40 nm and 40-60 nm were prepared by incorporating 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, 0.5 wt% MWCNTs by cement weight. Experimental results showed that the addition of 0.1 wt% MWCNTs with diameters of 10–20 nm effectively improved the freeze-thaw resistance of cement-paste. In addition, microstructural analysis of these cement-paste specimens showed that MWCNTs addition increased the materials’ initial porosity, but a proper amount of MWCNTs decreased the porosity of cement-paste after freeze-thaw cycles and effectively improved the pore size distribution. MWCNTs 10–20 nm in diameter were found to be the optimal size for improving the microstructure of these MWCNTs cement-paste
Resistance to deltamethrin in Triatoma infestans: microgeographical distribution, validation of a rapid detection bioassay and evaluation of a fumigant canister as control alternative strategy
Authors: Remón Carolina , Fronza Georgina , Maza Yanina , Sartor Paula , Weinberg Diego , Mougabure-Cueto Gastón
Published: April 2020

Triatoma infestans (Klug) (Hemiptera: Reduviidae) is the main vector of Chagas disease in the Southern Cone of America and resistance to pyrethroid insecticides has been detected in several areas from its geographical distribution. Pyrethroid resistance presents a complex geographical pattern at different spatial scales. However, it is still unknown if the toxicological variability is a common feature within villages of the Gran Chaco were high resistance was descripted. The objectives of this study were to determine: (a) the microgeographical distribution of the deltamethrin-resistance in insects from Pampa Argentina village, (b) the performance of the insecticide impregnated paper bioassay to evaluate deltamethrin-resistance in field collected insects and (c) the lethal activity of the fumigant canister containing DDVP against insects resistant to deltamethrin. High survival of T. infestans exposed to discriminant dose was observed in the samples of all the evaluated dwellings, suggesting that the resistance to deltamethrin is homogeneous at the microgeographical level. Resistance determination by impregnated paper bioassay was similar to traditional topical determination, highlighting the use of this rapid methodology in field large-scale monitoring. The fumigant canister was not effective against resistant insects, remarking the need to develop suitable formulations that ensure minimal toxicological risk and high effectivity.
HERACLES’ ITCH: AN ANALYSIS OF THE FIRST CASE OF MALE UTERINE DISPLACEMENT IN GREEK LITERATURE
Authors: Blanco Chiara
Published: April 2020

Scholars have long grappled with the nature of Heracles’ νόσος and his consequent feminization in Sophocles’Women of Trachis(=Trachiniae). Despite being triggered by a poisonous garment, which acts by means of magic incantation, the evolution of Heracles’ symptoms is described as a clinical case. Yet, making sense of his feminization from a scientific perspective has proven hard. In this paper, I investigate the symptoms experienced by Heracles, which Sophocles generically refers to as νόσος. The first part focusses on Sophocles’ description oferôsas a disease inTrachiniae. I then move on to dividing Heracles’ symptoms into two categories, which I will call νόσος1and νόσος2. The erotic passion for Iole which Heracles naturally experiences in the first part of the tragedy will be denoted by νόσος1, whereas νόσος2will refer to the magic-induced symptoms from which he suffers in the second and final part. In the final section of the paper I will seek to provide a scientific explanation for νόσος2and, ultimately, to describe the medical reasons behind Heracles’ feminization.
IMPERIAL JUSTICE? THE ABSENCE OF IMAGES OF ROMAN EMPERORS IN A LEGAL ROLE
Authors: Hekster Olivier
Published: April 2020

Roman emperors were at the pinnacle of society. They were supreme commanders of the armies, the highest priests and the ultimate source of law and justice. These three roles were made clear to the inhabitants of the empire from the reign of Augustus onwards through a variety of media. Public ceremonies showed emperors leaving the city for campaigns, and returning in triumph, at sacrifice, or sitting in judgement. Inscriptions likewise indicated the main roles of emperors through titulature or narrative. The military and the religious leadership of emperors were also made abundantly clear through public monuments and on centrally issued coinage. Yet, throughout Roman imperial history these last two types of source material are surprisingly silent on the emperors’ legal role.