bluuebunny/crossref_metadata_2025 huggingface dataset:
Formula-01: A phase Ⅱ study of disitamab vedotin (RC48) intravenous injection combined with BCG intravesical instillation in high-risk non-muscle invasive bladder cancer with HER2 high expression.
Authors: Tan Xingliang , Wang Yanjun , Wu Zhiming , Wei Wensu , Zhou Qianghua , Zhang Chichen , Deng Xinpei , Zheng Runhao , Zeng Jiamin , Chen Qiuhong , Yao Kai
Published: February 2025

TPS894

Background:
Intravesical instillation of bacillus Calmette-Guérin (BCG) is the first-choice treatment for intermediate- and high-risk non-muscle invasive bladder cancer (NMIBC). However, our previous study has demonstrated that HER2 was an independent predictor of poor BCG efficacy in NMIBC (Tan et al., European Urology Oncology, 2023). We found that high-risk NMIBC patients with HER2 high expression had the highest risk of disease recurrence and progression with 46.9% 2yr-RFS rate and 23.0% 2yr-PFS rate. Disitamab Vedotin (RC48) is an antibody-drugconjugate(ADC) targeting HER2 with a payload of MMAE. Formula-01 will evaluate the efficacy and safety of RC48 combining with BCG instillation in HER2 overexpression high-risk NMIBC patients.
Methods:
Formula-01 is an open-label, non-randomized, phase 2 trial. Patients must receive complete transurethral resection (TURBT) of bladder tumor (R0 resection) and did not accept BCG intravesical instillation and neoadjuvant chemotherapy or radiotherapy before. NMIBC was pathologically confirmed for all patients according to the 8th edition of the TNM staging system and the risk stratification was recorded basing on the American Urological Association (AUA)/Society of Urologic Oncology (SUO) guidelines.The pathology of NMIBC must be pure urothelial carcinoma and any divergent differentiation subtypes are excluded. This study is open at the Sun Yat-sen University Cancer Center (SYSUCC) and 70 patients are enrolled. The single-arm cohort will receive RC48 intravenous injection (2.0 mg/kg, iv drip, d1, Q2W, 8 cycles) combining with BCG intravesical instillation at least one year (D2PB302 strain, 1.2×10
8
CFU, 120 mg, dissolved in 40–50 ml of saline, 19 times in 1 yr). The primary endpoint is 2yr-RFS rate. Secondary endpoints include 1yr-RFS, 1yr-PFS, 2yr-PFS rate, bladder retention rate and safety. Exploratory analyses include determination of Her2 expression, molecular subtypes. The sample size calculation is based on the historical results of specific subgroup patients with 2yr-RFS rate of 46.9%, and we expected improvements to 70.0%. One-sample long-rank test was used to calculate the enrollment of 70 patients (α=0.05, β=0.8, lost-to-follow-up rate of 5.0%). The study began enrollment in February, 2024 and completed enrollment in October, 2024. Research approval was obtained from the SYSUCC Ethics Committee. Clinical trial information:
ChiCTR2400080767
.
Music and autobiographical memory
Authors: Θεοδοσοπούλου-Μπουρλογιάννη Δανάη
Published: February 2025

Η άνοια διαταράσσει το σύστημα αυτοβιογραφικής μνήμης, συμπεριλαμβανομένων των αναμνήσεων συγκεκριμένων επεισοδίων, προσωπικών εμπειριών και γεγονότων της ζωής του ατόμου. Όλα αυτά τα στοιχεία συμβάλλουν στην έννοια του εαυτού. Η διαταραχή της αυτοβιογραφικής μνήμης μπορεί να επηρεάσει την ψυχολογική ευημερία, συμβάλλοντας ενδεχομένως σε ψυχολογικά και συμπεριφορικά συμπτώματα και σε μειωμένη διαπροσωπική επικοινωνία. Στην παρούσα μελέτη διερευνάται πώς η λειτουργία της αυτοβιογραφικής μνήμης σε άτομα που ζουν με άνοια μπορεί να ενεργοποιηθεί μέσω εξατομικευμένων μουσικών παρεμβάσεων, βελτιστοποιώντας έτσι τις παρεμβάσεις αυτές και βελτιώνοντας ενδεχομένως τη φροντίδα της άνοιας. Χρησιμοποιούνται τρεις κύριες μέθοδοι: Στην πρώτη έρευνα έγινε σύνθεση δύο συστηματικών ανασκοπήσεων: η πρώτη επικεντρώθηκε στο πώς επηρεάζεται η αυτοβιογραφική μνήμη στους διάφορους τύπους άνοιας, η δεύτερη διερεύνησε την επίδραση της εξατομικευμένης μουσικής στη συμπεριφορά και τα ψυχολογικά συμπτώματα σε ασθενείς με άνοια. Η πρώτη συστηματική ανασκόπηση (28 μελέτες) διαπίστωσε διαφορές μεταξύ των υποτύπων άνοιας σε σχέση με το φαινόμενο της χρονικής διαβάθμισης, τις ανακληθείσες λεπτομέρειες των σημασιολογικών και επεισοδιακών αναμνήσεων και την ανάκληση αυτοπροσδιοριζόμενων αναμνήσεων. Η δεύτερη συστηματική ανασκόπηση (30 μελέτες) διαπίστωσε θετική αλλά όχι διαρκή επίδραση στα συμπεριφορικά και ψυχολογικά συμπτώματα. Η επίδραση ήταν μεγαλύτερη στις ενεργητικές εξατομικευμένες μουσικές παρεμβάσεις από ό,τι στην παθητική ακρόαση εξατομικευμένης μουσική. Στην δεύτερη έρευνα διεξήχθη ποιοτική θεματική ανάλυση των ραδιοφωνικών εκπομπών Desert Island Discs, για να κατανοήσουμε τις διαδικασίες ανταλλαγής μουσικών επιλογών με ιδιαίτερο προσωπικό νόημα και τον τρόπο με τον οποίο η μουσική υποστηρίζει την έννοια του εαυτού. Η ανάλυση εντόπισε τις συναισθηματικές διαστάσεις των αυτοβιογραφικών μουσικών αναμνήσεων, ιδιαίτερη σημασία είχε το συναίσθημα της νοσταλγία και ο τρόπος με τον οποίο η μουσική επιτρέπει στους ανθρώπους να μοιράζονται σημαντικές συναισθηματικές αυτοβιογραφικές αναμνήσεις, συμπεριλαμβανομένων των επώδυνων και δύσκολων αναμνήσεων. Στην τρίτη έρευνα μελετήθηκε μια ομάδα εστίασης με επαγγελματίες που χρησιμοποιούν μουσικές παρεμβάσεις με άτομα που ζουν με άνοια, για να συμβάλει στη θεωρητική εννοιολόγηση για εξατομικευμένη μουσική παρέμβαση. Η ανάλυση έδειξε πώς η μουσική ενεργοποιεί τα συναισθήματα, ιδίως κατά τη διάρκεια δύσκολων εμπειριών, ανέδειξε επίσης τη σημασία της ιστορίας κάθε ατόμου και την ανάγκη να βρεθούν συμπληρωματικοί τρόποι αξιολόγησης των μουσικών παρεμβάσεων στη φροντίδα της άνοιας.
Μετεξέλιξη των σύγχρονων ενόπλων συρράξεων εξαιτίας των υβριδικών απειλών και μέσων
Authors: Ζυμταρούδης Τάκης
Published: February 2025

Η παρούσα διατριβή εξετάζει ένα σύγχρονο εργαλείο, τις υβριδικές απειλές, που χρησιμοποιείται πλέον πολύ συχνά στα πεδία των συγκρούσεων ταυτόχρονα με συμβατικά μέσα. Ιδιαιτέρως δε, μελετά το κατά πόσο αυτές οι απειλές επηρεάζουν το υφιστάμενο δίκαιο των ενόπλων συγκρούσεων. Οι υβριδικές απειλές, αδιαμφισβήτητα, αποτελούν μια σύγχρονη πρόκληση που επηρεάζει δραστικά τα πεδία των μαχών και τους στρατιωτικούς διοικητές και, συνεπώς, η κατανόησή τους κρίνεται ιδιαίτερα σημαντική. Για τη μελέτη της εργασίας χρησιμοποιήθηκε η βιβλιογραφική ανασκόπηση αλλά και η εξέταση της πρακτικής των κρατών και μη κρατικών δρώντων σε σύγχρονα πεδία επιχειρήσεων. Αρχικά, αποσαφηνίστηκε ο υβριδικός τρόπος διεξαγωγής πολέμου και ακολούθησε η ανάλυση των βασικότερων υβριδικών απειλών και ο εντοπισμός τους σε σύγχρονες ένοπλες συρράξεις – αντιπαραθέσεις, δείχνοντας την αξία τους. Στη συνέχεια, εξετάστηκε το δίκαιο των ενόπλων συρράξεων και το πόσο αυτό επηρεάζεται από τη χρήση υβριδικών απειλών, δίνοντας έμφαση στα προβλήματα που αναγκάζεται να αντιμετωπίσει. Τέλος, παρατέθηκε ο ιδανικός τρόπος αντιμετώπισής τους τόσο από τα κράτη όσο και από τις συμμαχίες. Η έρευνα οδήγησε στη δόμηση μιας ολοκληρωμένης θεωρίας σχετικά με την ανάπτυξη υβριδικών απειλών, οι οποίες θα πρέπει να αναπτύσσονται τόσο σε συνδυασμό μεταξύ τους όσο και με τη χρήση στρατιωτικών μέσων. Ακόμα, προτάθηκαν αρκετές λύσεις για την αντιμετώπιση των προβλημάτων που δημιουργεί η ανάπτυξη των υβριδικών απειλών στο δίκαιο των ενόπλων συρράξεων και σημειώθηκε ο τρόπος με τον οποίο οι ένοπλες δυνάμεις πρέπει να αντιμετωπίζουν την πρόκληση των υβριδικών απειλών.
Life Cycle Assessment of Microalgae-Based Products for Carbon Dioxide Utilization in Thailand: Biofertilizer, Fish Feed, and Biodiesel
Authors: Rafiq Adeel , Morris Cameron , Schudel Abigail , Gheewala Shabbir
Published: February 2025

Background Microalgae-based products offer a sustainable solution for food, fuel, and agricultural inputs, presenting environmental benefits and economic opportunities. A comprehensive assessment is needed to understand their potential in supporting sustainability goals, considering the complex interplay between production methods, energy sources, and environmental impacts. Methods This study evaluated the environmental impacts of three microalgae-derived products – biodiesel, fish feed, and biofertilizer – through a comprehensive life cycle assessment. Nine scenarios were explored comparing three electricity profiles (current Thai mix, 50% renewable/50% current mix hybrid, 100% renewable) across the three products. The assessment evaluated environmental impacts and potential economic benefits of transitioning to these microalgae-based alternatives. Results and discussion All products demonstrated potential for significant environmental benefits under increased renewable energy scenarios. Fish feed consistently exhibited the lowest environmental impacts across all categories examined, showing substantial improvements with increased renewable energy use. With an annual demand of 0.4 million tonnes, fish feed could generate USD 560 million in revenue and reduce CO2 emissions by 1.1 million tonnes. Fulfilling the projected biodiesel demand of 4,015 million liters per year through microalgae production could yield approximately USD 3.5 billion in revenue and reduce CO2 emissions by 30 million tonnes compared to conventional fossil-based diesel. Additionally, algal biofertilizer production could meet a 5 million tonnes annual demand, offering USD 2 billion in revenue while reducing CO2 emissions by 6 million tonnes yearly. Collectively, these products could offset 37 million tonnes of CO2, representing about 14% of Thailand’s total CO2 emissions, contributing significantly to the country’s Nationally Determined Contribution (NDC) target of 20-30% greenhouse gas emissions reduction. Conclusion Transitioning to microalgae-based products could transform the aquaculture, energy, and agricultural sectors, potentially supporting the national climate change mitigation goals, if implemented.
Factors Influencing Food Safety and Hygiene Practices among Food Vendors in the Bibiani-Anwhiaso-Bekwai Municipality.
Authors: Besseah Yeboah Eric , Nseebi Acquah Eric , Adu-Amankwaa William , Twum Peter , Eshun Eric , Ofosua Asantewaa Regina , Ziema Thomas
Published: February 2025

Abstract Background Food-related illnesses have become more prevalent globally over time, having a detrimental impact on the health and economic prosperity of both emerging and developed nations. A large percentage of these diseases are caused by food-borne infections, both globally and locally. Objective To determine food safety and hygiene practices of food vendors in the Bibiani Municipality. Method A descriptive cross-sectional design was employed in this study. A quota sampling technique was used to select 152 food vendors from Bibiani. The community was divided into three parts: Bibiani, Anwhiaso, and Bekwai. The data collection tool was structured questionnaires and exported into Statistics and Data 15.0 (STATA 15.0). The data were analyzed descriptively and presented as frequency counts, simple percentages, and tables. Results Out of 152 respondents, 89.5% put leftover foods in the refrigerator for preservation, 4.6% put food pans in water, 76.3% used a serving spoon when dishing food, 5.3% used bear hands, 64.5% used soap and water during hand washing, and 73.0% had done a medical examination; 82.2% wore aprons as well as hair covers during the cooking and serving of food. Conclusion The majority of respondents had satisfactory safety and hygiene practices, while some still had several unsafe hygienic practices. Recommendation The government of Ghana and MMDAs should establish the pre-requisite standard operating procedures for all institutions undertaking hospitality regarding food safety and hygiene.
Case Report: First report of chronic osteomyelitis caused by Staphylococcus hyicus: a zoonotic pathogen with underreported clinical significance
Authors: Ernandes Helmi , Kaoual Salma , Bahroun Sami , Sallem Sahar , Triki Ameur , Bellaaj Ameni , Zgolli Asma , Daghfous Samir , Bouhalila Besbes Sophia , Kooli Ikbel
Published: February 2025

Background Staphylococcus hyicus is a zoonotic pathogen primarily associated with animal infections. Human infections are exceedingly rare, with only six cases documented in the literature. The pathogen’s role in chronic osteomyelitis of long bones has not been previously reported, presenting unique diagnostic and therapeutic challenges. Case Report We report the first case of chronic osteomyelitis of long bones caused by methicillin-resistant S. hyicus in a 34-year-old male farmer with a history of recurrent osteomyelitis following trauma and livestock exposure. The patient presented with purulent discharge from two fistulae on the medial aspect of the right thigh. Imaging studies revealed bony sequestration, periosteal reaction, and multiple fistulous tracts consistent with Cierny-Mader stage III chronic osteomyelitis. Microbiological identification of coagulase-negative methicillin-resistant S. hyicus was achieved via culture and phenotypic analysis of aspirates from the fistulae and intraoperative samples, with confirmation via matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). A multidisciplinary treatment strategy was implemented, combining extensive surgical debridement and dead space management with a 24-week tailored antibiotic regimen. The regimen included intravenous teicoplanin and ciprofloxacin for 14 days, followed by oral ciprofloxacin and cotrimoxazole. The patient achieved sustained remission with no recurrence at 2.5 years of follow-up. Conclusion This case underscores the zoonotic potential of S. hyicus and highlights its capacity to cause severe, persistent infections in humans, particularly in individuals with occupational or environmental exposure to livestock. Advanced diagnostic techniques such as MALDI-TOF MS are essential for accurate identification, mitigating the risk of misdiagnosis due to phenotypic similarities with other staphylococcal species. Clinicians should consider S. hyicus in the differential diagnosis of chronic osteomyelitis in patients with relevant exposure histories to enable timely and targeted therapeutic interventions.
The Role of Antibiotic Therapy in the Management of Facial Fractures: A Systematic Review
Authors: Michalczyk Katarzyna , Sobolewska Dominika , Wirkijowska Małgorzata , Gajek-Flanczewska Wiktoria , Flanczewski Sebastian , Woźniak Paulina , Wietrzykowska Ewa , Śliwińska Martyna , Podraza Anna , Wójtowicz Katarzyna , Walczak Agata
Published: February 2025

Purpose:The administration of prophylactic doses of antibiotics is a standard procedure in the treatment of maxillofacial fractures. Maxillofacial fractures occur most frequently, and antibiotic therapy is often overused before and after surgery. Despite numerous studies, there are still no clear-cut treatment regimens. The present study aimed to empirically evaluate this aspect.Materials and methods:The authors  conducted  an extensive review  of  articles available  in PubMed, Google Scholar, UpToDate, Science Direct, and Cochrane databases. The keywords mandibular fractures, maxillary fractures, antibiotic prophylaxis, antibacterial agents, postoperative antibiotic prophylaxis, mandible fracture; antibiotics, open reduction, internal fixation. Studies published between 1970 and 2021 were included in the review.Results:Adding postoperative antibiotic prophylaxis to the standard preoperative and/or perioperative antibiotic regimens showed no significant reduction in the risk of surgical site infections. Similarly, no difference was observed in infection risk when the analysis focused specifically on mandibular fractures or procedures involving open surgical techniques. We should also take into account the patient's general diseases that increase the risk of infection. The situation in which prophylaxis unequivocally needs to be applied is the connection of the fracture gap with the oral cavity (open fractures) or sinuses.Conclusion:The evidence for prophylactic antibiotic use in maxillofacial fractures is weak and inconsistent, with no clear recommendations on type, dose, or duration. Each treatment should be individualized and tailored to the particular clinical case. Particular attention should be paid to the patient's medical condition, comorbidities, and the type and extent of the injury. Routine antibiotic therapy in patients belonging to the low-risk group carries negative consequences, such as the development of antibiotic-positivity.
The impact of non-ionizing electromagnetic radiation emitting devices on the male reproductive system
Authors: Sienkiewicz Michał , Pawłowski Bartosz , Kłusek Magdalena , Zatłoka-Mazur Dorota , Klimas Filip , Rusiński Kacper , Sienkiewicz Bartłomiej
Published: February 2025

With today's technological advances, people spend more and more time using various devices that emit non-ionizing radiation (NIR), such as mobile phones, laptops or WiFi networks. Nowadays, the role of these devices in the human lifestyle seems to make exposure to NIR unavoidable. This exposure, especially when prolonged, has been reported as one of the possible lifestyle factors contributing to reduced fertility, especially in men. The aim of the study was to analyse the current state of knowledge on the impact of NIR emitted by modern devices on the functioning of the male reproductive system and to identify possible mechanisms behind it. The research method used was a literature review on the PubMed platform. A total number of 35 articles from years 2007-2024 were analysed.
According to the scientific literature, exposure to NIR may affect spermatozoa through thermal and non-thermal mechanisms, the most important of which appears to be increased production of reactive oxygen species (ROS), which leads to oxidative stress and cellular damage in the reproductive system. NIR exposure can adversely affect semen parameters such as sperm motility, viability and concentration, alter hormonal mechanisms regulating reproduction and induce morphological changes in reproductive tissues. However, studies conducted in this context often provide inconsistent results, hence the exact effect of NIR on the male reproductive system remains unknown. Therefore, further research is needed to accurately determine the effects of NIR on male fertility and to provide appropriate health recommendations.
The influence of endocrine disrupting chemicals
Authors: Pawłowski Bartosz , Sienkiewicz Michał , Kłusek Magdalena , Zatłoka-Mazur Dorota , Żybowska-Męczyńska Monika , Klimas Filip , Sienkiewicz Bartłomiej , Rusiński Kacper , Potoczek Adriana
Published: February 2025

On a daily basis, everyone is exposed to many chemical compounds that have been classified as endocrine disrupting chemicals (EDCs). These are natural and artificially produced substances that are widely available in the environment today. The aim of the study is to determine the effect of endocrine disrupting chemicals on hormonal processes occurring in the human body and to determine their mechanisms of action. The research method used was a literature review on the Pubmed platform.
Studies show that EDCs affect prenatal growth, thyroid function, glucose metabolism, obesity development, and puberty and fertility processes by mimicking hormones naturally occurring in the human body, which very often leads to disorders in the hormonal axis at various levels. Recent research reports say that EDCs interact through epigenetic mechanisms. These substances are considered safe individually, but the subject of research remains the "cocktail effect", which consists in exposing several EDCs to the body at the same time.
The key here is to limit human contact with these substances as much as possible. Studies have so far proven the negativin effects of many of them on our body, but many of the long-term effects have yet to be studied. Fortunately, more and more countries are introducing restrictions on the use of these substances and are looking for methods to replace them with less harmful substitutes.
Further research is needed to understand the effects of these substances on humans, which will further enable the development of appropriate regulation of EDCs.
Postpartum Depression: A Closer Look at Treatment with Zuranolone
Authors: Brudniak Katarzyna , Garbino Karolina , Czyczerska Magdalena , Szuścik Antoni , Gadżała Katarzyna , Przygodzka Sabina , Mach Maciej , Rutkiewicz Maciej
Published: February 2025

Postpartum depression (PPD) is a severe mood disorder that affects approximately 1 in 7 women and 1 in 10 men, often occurring in the first year after childbirth. Its etiology is multifactorial, including hormonal changes, genetic predisposition, and environmental stressors, though its true prevalence is likely underestimated due to stigma and underreporting.  Untreated PPD can have long-term consequences for maternal-child relationships, child development, and maternal health, including increased suicide risk. The condition remains underdiagnosed and undertreated due to stigma and systemic barriers to care. Zuranolone, an oral neuroactive steroid and positive allosteric modulator of GABA-A receptors, has recently garnered attention as a novel therapeutic option with the potential to target these underlying pathophysiological mechanisms.
Aim of the study: The aim of this study is to provide a comprehensive review of the therapeutic efficacy, safety, and pharmacological characteristics of Zuranolone in the treatment of postpartum depression (PPD), with focusing particularly on its mechanism of action, pharmacokinetics and clinical trial outcomes.
Materials and methods: A systematic literature review was conducted using PubMed and other medical databases. Keywords included "postpartum depression," "zuranolone," "GABA-A modulators,". Data from clinical trials, reviews, and pharmacological studies were analyzed.
Conclusions: Zuranolone has provided significant efficacy with a very rapid onset of action in the reduction of symptoms in postpartum depression and long-term improvements observed over several weeks. Its mechanism of action, targeting GABAergic dysregulation, offers a novel therapeutic pathway for addressing postpartum psychiatric disorders. Future longitudinal studies are required to explore its long-term impact on maternal mental health.
Fungal Infections: Epidemiology, Clinical Challenges, and Advances in Diagnosis and Treatment - a review
Authors: Klimas Filip , Zatłoka-Mazur Dorota , Rusiński Kacper , Zając Piotr , Pawłowski Bartosz , Sienkiewicz Michał , Potoczek Adriana , Zięba Zuzanna , Pudełko Iwona
Published: February 2025

Fungal infections are a serious public health threat, affecting a wide variety of populations worldwide. This review presents the current state of knowledge on fungal infections, focusing on epidemiology, etiology, clinical manifestations, and emerging trends. Findings are based on 35 peer-reviewed studies and focus on both well-known and emerging fungal pathogens, diagnostic advances, and therapeutic challenges. In addition, this review emphasizes the role of environmental and social factors in shaping the dynamics of fungal disease and highlights the importance of a global, multidisciplinary effort to combat the rise in fungal disease. The literature for this review was collected from PubMed and Google Scholar using the key words “fungal infections” combined with “epidemiology”, “etiology”, “risk factors”, “symptoms”, “complications”, “treatment”, and “trends”.
Analysis of the utilization of Mandala Krida Stadium and GOR Among Rogo assets
Authors: Wahyuni Sri , Irawati Novi , Muni Joao
Published: February 2025

This article gives an overview of the literature on asset management for multi-unit systems with an emphasis on two multi-asset method: Benefit Cost Analysis and SWOT Analysis. As asset systems become more complicated, researchers have employed different terms to refer to their specific problems. With an objective to facilitate readers in searching conducive studies to their interests, this paper establishes a novel classification scheme for multi-unit systems in accordance with essential features such as diversity of assets and intervention options. Moreover, discerning differences in characteristics between cross-component and cross-asset interactions, we select three types of potential multi-component dependencies (performance, stochastic, and resource) and extend their notions to be applicable to multi-asset systems. This comprehensive information allows us to offer the insights into the current trends in multi-asset maintenance. We expect that the output of this review paper will not only stress research gaps in multi-asset systems, but more importantly help systematise future studies on this aspect.
Analysis of Public Sector Financial Performance With The Value For Money Approach In Bogor Regency
Authors: Erica Denny , Ratiyah Ratiyah , Shah Syed Muhammad Abdul Rehman
Published: February 2025

Financial performance is essential to ensure accountability and efLiciency in public sector organizations, especially in government. Public Sector Financial Performance requires assessment as a form of evaluation, so that Linancial performance becomes more optimal. The process of regional Linancial management consists of three stages: planning, implementation, and accountability, according to Minister of Home Affairs Regulation Number 13 of 2006 Concerning Regional Finavfc ncial Management Guidelines. The Financial Performance of the Bogor Regency Government in this study uses the Value for Money (VfM) approach with 3 (three) main factors, namely: Economic, EfLiciency, and Effectiveness of the 2014-2023 Fiscal Year. The Linancial reports produced have been in accordance with government accounting standards agreed upon by all parties involved, therefore used as a guideline to produce fair, clear, and complete Linancial reports to ensure transparency. The budget implementation report is a Linancial report that describes the future budget and budget allocation managed by the government during the reporting period. The Linancial performance of the Bogor Regency public sector is economical, with an average of 100.58%. However, efLiciency is still a concern, with an average of 99.21%, which needs more attention. The results of this analysis can be used as evaluation material for the Bogor Regency Government so that its public sector Linancial performance is more efLicient, so that the Bogor Regency Government can improve the quality of service to the community to be more optimal.
ARTES ENTRELAÇADAS À EDUCOMUNICAÇÃO:
Authors: Reis Vivian Aparecida dos , Marquezan Fernanda Figueira , Ghisleni Taís Steffenello
Published: February 2025

O estudo propõe a integração entre o ensino de arte na educação infantil e a Educomunicação como prática pedagógica inovadora. Embasado na Base Nacional Comum Curricular (Brasil, 2017) e autores como Malaguzzi, Soares, Santaella, Ferraz e Fusari, busca-se enriquecer o processo educativo. A proposta pedagógica desenvolvida, fundamentada nas quatro linguagens da arte, incorpora as potencialidades das novas tecnologias e da comunicação, promovendo a interação entre professores. Destaca-se a importância de adaptar as práticas à realidade das crianças. A metodologia envolveu análise bibliográfica para criar uma sequência didática com práticas educomunicativas. Como resultado, o material será disponibilizado para ser aplicado por professoras da educação infantil, visando uma educação comprometida com experiências inovadoras e desenvolvimento de habilidades.
INTELIGÊNCIA ARTIFICIAL NO ENSINO SUPERIOR: ENTRE OPORTUNIDADES E DESAFIOS
Authors: Vieira Luís , Rodrigues Liliana
Published: February 2025

A utilização da inteligência artificial tem vindo a verificar-se um fenómeno emergente, por conta dos mais recentes desenvolvimentos tecnológicos. Por este motivo e considerando as potencialidades desta tecnologia, procuramos, neste artigo, explorar e compreender as oportunidades e os desafios que se encontram relacionados com a utilização da inteligência artificial na educação superior, a partir de uma pesquisa de revisão bibliográfica, assente numa metodologia qualitativa. Os resultados apontam para diversas oportunidades e vários desafios relacionados com a utilização da inteligência artificial na educação superior. Aqui destacamos uma educação mais adequada e acessível, o enriquecimento do processo de ensino-aprendizagem, a necessidade de se alocar esforços em garantir a implementação responsável, sustentável e justa da inteligência artificial e a necessidade de formação e de capacitação para as possibilidades de utilização da inteligência artificial na educação. Neste trabalho também são apresentadas considerações teóricas e reflexões com o intuito de contribuir para a discussão em torno da utilização da inteligência artificial na educação.
DESAFIOS E PERSPECTIVAS DO TRABALHO DOCENTE EM TEMPO DE INTELIGÊNCIA ARTIFICIAL
Authors: Novais Juliana Oliveira de Santana , Djanira Pacheco e Zan Dirce
Published: February 2025

O objetivo deste artigo é levantar questões sobre o futuro da profissão docente, em especial sobre as consequências da adoção da Inteligência Artificial (IA) nas políticas públicas de educação e nas escolas. A hipótese levantada é que as reconfigurações contemporâneas do capitalismo - principalmente as reformas neoliberais, a reestruturação produtiva e a inserção das tecnologias em larga escala no ambiente de trabalho - além de intensificarem o controle e a precarização do trabalho docente, estão “substituindo” uma parcela de professores gerando desemprego estrutural e aumentando ainda mais a exploração e expropriação da mão de obra docente. Dessa forma, as questões que orientam a nossa reflexão aqui são: como e em que medida as novas tecnologias afetam o trabalho do professor? Até que ponto as novas tecnologias em especial, as de Inteligência Artificial poderão replicar e ressignificar o trabalho docente? Como as políticas públicas de educação voltadas para Inteligência Artificial estão sendo articuladas na área educacional? O artigo trata-se de um ensaio, onde refletiremos sobre o uso da IA na educação e as possíveis consequências na profissão docente. Para esta reflexão, partimos da compreensão de que o processo de exploração do trabalho docente, ao introduzir um grande aparato tecnológico na educação, poderá se dar de forma ainda mais perversa com a possível “substituição”, pelo menos em alguns setores, da mão de obra docente pela Inteligência Artificial. Nesse sentido, é possível afirmarmos que se faz necessário ressignificar o trabalho docente.
POSSIBILIDADES CARTOGRÁFICAS COM A LITERATURA
Authors: Ortolan Cavalleri Cihbelle Carolyne , Olegário Fabiane
Published: February 2025

O artigo tem como objetivo compreender como os estudantes do 5º ano do Ensino Fundamental de uma escola particular localizada no Vale do Taquari/RS se relacionam com os textos literários e de que maneira essa relação lhes possibilita ampliar os conhecimentos, por meio de experiências de leitura. Para aprimorar o entendimento do conceito de experiência, o texto utiliza as investigações de Larrosa (2004) e considera as ponderações de Schwartz (2010), no que diz respeito à importância da experiência como formadora de sujeitos. No que tange à literatura, a investigação também conta com Perissé (2006) e Rouxel; Langlade e Rezende (2013). O estudo é orientado pelo método cartográfico, com base nos estudos de Kastrup (2007), Barros e Passos (2009), Romagnoli (2009), entre outros. Trata-se de um método cujo princípio é acompanhar processos (Kastrup, 2013). A pesquisa-intervenção realizada numa turma do 5º ano do Ensino Fundamental sugere que um dos pontos que conecta as experiências à literatura diz respeito à interação dos estudantes, que é desenvolvida através de práticas proporcionadas em aula. Por fim, este estudo mostra que as práticas estabelecidas nos Seminários movimentaram o pensar reflexivo das crianças, possibilitando-lhes experiências e encontros potentes com os textos literários.
A LITERATURA INFANTIL COMO NORTEADORA DE PRÁTICAS PEDAGÓGICAS ANTIRRACISTAS NA EDUCAÇÃO INFANTIL
Authors: ALEXANDRE MOTA JULIA GABRIELLA , Reis Darianny Araújo dos
Published: February 2025

O presente relato versa sobre uma prática pedagógica realizada em um Centro Municipal de Educação Infantil pertencente à rede pública municipal informação temporariamente suprimida para garantir o anonimato da autoria. Entrelaça os pressupostos da pedagogia antirracista com a literatura infantil no processo educativo desenvolvido com crianças pequenas, no contexto do Programa de Iniciação à Docência (PIBID), subprojeto Pedagogia, vinculado à Faculdade de Educação da informação temporariamente suprimida para garantir o anonimato da autoria. A partir desta experiência, buscamos discutir a necessidade de descolonizar as práticas educativas, ao tomarmos como base a implementação da Lei 10.639/2003, que tornou obrigatório o ensino da história e cultura afro-brasileira e africana em todas as escolas do país. A literatura infantil com protagonismo de personagens negros constituiu-se em principal material linguístico e simbólico de mediação para a conversa com crianças. A partir da obra “O pequeno príncipe preto”, de Rodrigo França (2020), problematizamos a questão da inferioridade racial ao colocarmos luz sobre o combate à ideologias racialistas e pseudocientíficas. Além disso, buscamos incentivar a formação do leitor literário numa perspectiva antirracista e descolonizadora, colaborando para a formação da identidade de crianças negras. Dos saberes construídos nesta experiência, pela qual permitiu-nos explicitar o papel da literatura infantil como aliada à luta antirracista, depreendemos a necessidade de ampliar as discussões sobre identidades, culturas e subjetividades nas práticas educativas, a partir de uma pedagogia crítica que possibilite experiências literárias antirracistas nas instituições de educação infantil.
 
Palavras-chave: Pedagogia antirracista; Literatura infantil; PIBID.
CHATGPT E EDUCAÇÃO NA CIBERCULTURA: FUNDAMENTOS E PRIMEIRAS APROXIMAÇÕES COM INTELIGÊNCIA ARTIFICIAL
Authors: Maia do Amaral Mirian
Published: February 2025

Professora Titular-livre da Universidade Federal Rural do Rio de Janeiro (UFRRJ, atuando no Instituto de Educação e no Programa de Pós-Graduação em Educação (PPGEDUC), Edméa Santos organizou, em colaboração com Alexandre Chagas e João Bottentuit Junior, o livro "ChatGPT e educação na cibercultura: fundamentos e primeiras aproximações com inteligência artificial" – volume 1, publicado pela Editora EDUFMA, em 2024, tendo em vista reunir uma coletânea de artigos escritos por um coletivo de docentes e pesquisadores estudiosos das questões contemporâneas, a fim de discutir a integração da inteligência artificial (IA) à área de educação, com foco especial no uso do ChatGPT.
Teorías éticas en el Trabajo Social: Cuestionario de autoevaluación ética (C-AE)
Authors: Idareta Goldaracena Francisco
Published: February 2025

Las teorías éticas orientan nuestra práctica profesional en el Trabajo Social, pero muy pocos/as son capaces de identificarlas. Con el propósito de que en el Trabajo Social cada profe-sional pueda identificar y medir objetivamente las teorías éticas de las que se derivan sus propias valoraciones, hemos elaborado el Cuestionario de Autoevaluación Ética (C-AE). Un cuestionario que está inspirado en la Theoretical Evaluation Self Test (TEST) de Daniel Coleman (2004), una escala desarrollada para medir la orientación teórica de los/as terapeutas. Por tanto, el objetivo del presente artículo es doble: en una primera parte, analizar algunas de las diferentes teorías éticas existentes que más han podido incidir en la práctica profesional en el Trabajo Social y, en una segunda parte, presentar las particularidades del C-AE.
EL IMPACTO SOCIECONÓMICO DEL SISTEMA DE ATENCIÓN A LA DEPENDENCIA EN EL ÁMBITO FAMILIAR. UN ESTUDIO DE CASO
Authors: Bódalo Lozano Esther
Published: February 2025

La crisis económica iniciada en España en 2008 afectó al conjunto de los sistemas de protección social, entre ellos el Sistema de Autonomía y Atención a la Dependencia. La implementación de la Ley 39/2006, de Promoción de la Autonomía Personal y Atención a las Personas en situación de Dependencia se vio condicionada por los numerosos cambios legislativos que se aprobaban según la situación económica y social del país. Una de las normas jurídicas que mayor trascendencia ha tenido en el modelo de cuidados de larga duración en España ha sido el Real Decreto Ley 20/2012 que introdujo restricciones presupuestarias y de derechos en las personas en situación de dependencia y en las personas cuidadoras en el hogar familiar. Las familias han sido unas de las principales afectadas en un país donde hay una menor implicación del Estado en materia de res-ponsabilidad social en torno al cuidado.
El presente trabajo comienza describiendo muy someramente el papel que han jugado las familias, en concreto las mujeres como figura de sostén del cuidado, y que, en parte, suplen las carencias estatales, para centrarnos posteriormente en el objetivo general de analizar los costes sociales del cuidado, es decir, las implicaciones que tiene que asumir, las funciones de cuidados y el coste de oportunidad que repercute en las personas cui-dadoras, especialmente desde un punto de vista económico y social.
Del análisis del estudio podemos afirmar que, por lo general, aunque la gran mayoría de las personas cuidadoras, se encuentran en cierta manera protegidos/as por las ayudas y servicios de las administraciones públicas, estiman que estas son insuficientes para cubrir todos los costes y necesidades que se derivan del cuidado.
RECORRIDO EXPLORATORIO POR LA INVESTIGACIÓN EN TRABAJO SOCIAL A TRAVÉS DE LAS PÁGINAS DE TRABAJO SOCIAL HOY. UN ANÁLISIS DE LOS DIEZ ÚLTIMOS AÑOS DE LA REVISTA
Authors: Yusta Tirado Rubén
Published: February 2025

La investigación es uno de los actos claves en cualquier disciplina profesional, que genera el avance, la evolución y, en definitiva, la mejora de la disciplina y de la intervención realizada con las personas usuarias.
En los últimos años, la necesidad de que intervención e investigación vayan de la mano ha sido un elemento presente en la mayor parte de discursos profesionales y siendo un aspecto cada vez más presente en la formación y especialización profesional.
El presente artículo muestra una investigación llevada a cabo a través del estudio de las publi-caciones de los diez últimos años de Trabajo So-cial Hoy (2013-2022), reparando en aspectos tan importantes como el perfil de los/as autores/as, la procedencia de los artículos o el ámbito al que se refieren y analizando situaciones tales como la brecha de género existente en investigación, el efecto Matilda o la globalización del conocimiento en Trabajo Social.
LA SOLEDAD COMO FENÓMENO SOCIAL Y ESTRUCTURAL: UNA REFLEXIÓN CRÍTICA DESDE LA INTERSECCIONALIDAD
Authors: Fernández-Roses Daniel , García-Aguña Sonia , De Gea Grela Pablo
Published: February 2025

Este artículo aborda el concepto de soledad desde una perspectiva crítica, centrándose en la distinción entre soledad deseada y no deseada, y su relación con el aislamiento social. El objetivo es analizar el concepto desde una perspectiva interseccional feminista, con el fin de explorar cómo las estructuras sociales y de desigualdad influyen en la experiencia de la misma. Todo ello bajo la premisa de que la soledad, más allá de ser un fenómeno individual subjetivo, es el resultado de factores sociales complejos que han de atenderse.
EL IMPACTO DEL DESEMPLEO Y DESAFÍOS PARA LAS MUJERES MAYORES DE 45 AÑOS: ANÁLISIS DE LA EFECTIVIDAD DE LOS ITINERARIOS PERSONALIZADOS DE INSERCIÓN
Authors: González Noda Cristina María , Fernández Méndez Felipe Santiago , Díaz González José Manuel
Published: February 2025

El desempleo es un problema que genera impactos significativos a nivel individual y social. Implica escasez de recursos y estrategias, lo que lo convierte en un factor determinante para la integración social, el progreso personal y el bienestar. Este fenómeno se agudiza para las mujeres mayores de 45 años, que enfrentan mayores dificultades para acceder al mercado laboral. Se realizó una revisión bibliográfica y una investigación cuantitativa con 272 mujeres desempleadas. Se analizaron variables sociodemográficas y de intervención profesional. Las mujeres en esta franja a menudo tienen formación limitada y trayectorias laborales irregulares y cortas. Los hallazgos sugieren la necesidad de programas formativos y de orientación para mejorar la empleabilidad y calidad de vida de este grupo afectado, contribuyendo así al diseño futuro de intervenciones que aborden esta problemática de manera efectiva.
Battery and Ultra-Capacitor Based Hybrid Energy Storage System Utilizing a Multi-Input DC-DC Buck-Boost Converter
Authors: Mahmud Monowar , Abedin Tarek , Mostofa Kazi Zehad , Rahman Atiqur , Basher Mohammad Khairul , Nur-E-Alam Mohammad
Published: February 2025

Hybrid power systems have evolved into a vital component of contemporary power networks, finding application in various domains ranging from automotive to small-scale off-grid setups. Their purpose is to optimize the utilization of diverse energy sources. This study delves into the efficacy of integrating ultra-capacitors and batteries synergistically. Employing a multi-input converter to drive a variable DC load, the aim is to minimize losses and expenses. In the proposed configuration, a single inductor is utilized, facilitating the integration of a variable array of distributed energy sources. Notably, this converter expedites ultra-capacitor (UC) charging by offering a low inductance pathway, distinguishing it from conventional multi-input DC-DC converters. This proposed topology is bidirectional and adaptable to accommodate varying numbers of energy sources. The obtained numerical results reveal the converter’s effectiveness in stabilizing output voltage and current, making it suitable for multiple applications like electric vehicles, fuel cell systems, and renewable energy integration. Additionally, in the proposed topology, the results showed that it could charge a 2000F UC from a 300V source from 40% to 100% in just 400s and from a 150V battery from 20% to over 90% in just 200s due to the single inductor present in the charging path. Moreover, the load voltages are below 2% in all operational modes when either one or two sources are driving the load. Future research may focus on refining control algorithms to further enhance system efficiency and expand its applicability across different sectors.
DIAGNOSTICS OF OPTIC DISC DRUSEN – MULTIMODAL IMAGING POSSIBILITIES
Authors:   Department of Ophthalmology, Military Institute of Aviation Medicine, Warsaw, Poland, Szabelska Paulina , Różycki Radosław ,   Department of Ophthalmology, Military Institute of Aviation Medicine, Warsaw, Poland, Gołębiewska Joanna ,   Department of Ophthalmology, Military Institute of Aviation Medicine, Warsaw, Poland
Published: February 2025

Abstract: Optic nerve drusen (OND) are calcified deposits in the optic nerve head. Though often asymptomatic, they can compress small blood vessels, disrupting local blood flow and potentially damaging nerve fibers, which may lead to visual loss. Regular monitoring of the patients is recommended in which multimodal imaging helps.
Our study presents the diagnostic possibilities of multimodal imaging to illustrate pathology observed in OND and summarize clinical data about these methods.
High Cirrhosis Surgical Volume Centers Have Reduced Postoperative Mortality in Patients With Cirrhosis Undergoing Major Surgery
Authors: Ghandour Bachir , Kaplan David E. , Mahmud Nadim
Published: February 2025

Patients with cirrhosis have increased surgical risk and require care team expertise. We explored the association between center cirrhosis surgical volume and postoperative mortality in a large VA data set. In this retrospective cohort study of 14,500 major surgeries in patients with cirrhosis, we found in adjusted analysis that high-volume centers (>16 surgeries in past year) had a 36% reduced hazard of postoperative mortality through 90 days vs low-volume centers (<9 surgeries in past year; hazard ratio 0.64, 95% confidence interval 0.43–0.94, P = 0.02). These findings demonstrate the importance of triaging patients with cirrhosis to high-volume centers for major surgery when feasible.
INIQUIDADES NO ACESSO ÀS CIRURGIAS CARDÍACAS NO BRASIL: UMA REVISÃO INTEGRATIVA
Authors: Lima Jaqueline Maria de Oliveira , Rosaneli Caroline Filla , Marcucci Fernando Cesar Iwamoto , Corradi-Perini Carla
Published: February 2025

Essa pesquisa busca discutir as iniquidades no acesso às cirurgias cardíacas no Brasil e sua relação com os fatores sociodemográficos, econômicos e regionais. Trata-se de uma revisão integrativa da literatura que teve como pergunta norteadora “Quais os fatores relacionados às iniquidades no acesso à cirurgia cardíaca no Brasil?”.  Para respondê-la, foi realizada em fevereiro de 2024, uma busca na base de dados da Biblioteca Virtual em Saúde (BVS), utilizando-se os descritores DeCS/MeSH combinados a partir do operador boleano “AND”: “cardiac surgery” and “inequality” and “Brazil” e “cardiac surgery” and “access” and “Brazil”. Dos 32 artigos encontrados, 13 foram selecionados após leitura dos resumos e textos completos. Diversas barreiras foram encontradas como questões relacionadas a desigualdades regionais e fatores sociais ao acesso às cirurgias cardiovasculares; desigualdades socioeconômicas; tempo de espera para cirurgias cardiovasculares; abordagens relacionadas a orientações pré e pós-cirurgias e recuperação hospitalar/domiciliar; problemas com acesso à cirurgia pediátrica; questões relacionadas ao acesso da informação pela classe médica; e fatores relacionados à formação de cirurgiões cardiovasculares. Diante dos desafios e das desigualdades como barreiras ao acesso às cirurgias cardíacas, faz-se necessário estruturar estratégias eficazes para garantir que todos os brasileiros tenham acesso igualitário e cuidados de saúde integral.
Differential diagnosis of non-traumatic knee hemarthrosis (case report)
Authors: Roskidaylo A. A.
Published: February 2025

Hemarthrosis (HA) of the knee of non-traumatic origin is rarely encountered in the practice of a traumatologist-orthopedic surgeon. The differential diagnosis of this pathology requires a thorough medical history tacking and clinical examination of the patient, and a knee joint aspiration can only confirm the presence of blood in the joint. A diagnostic arthroscopy with a synovial biopsy helps to clarify the diagnosis. The most common causes of non-traumatic HA are tumors of vascular or synovial origin, tumor metastases and the use of high-dose anticoagulants in combination with a vascular malformation.

A clinical observation of the development of symptoms of non-traumatic HA on the background of anticoagulant use is presented, where the task of the orthopedic surgeon was to identify the true cause of the disease.
Pelubiprofen is a new member of the class of non-steroidal anti-inflammatory drugs for the treatment of back pain and pain in rheumatic musculoskeletal disorders
Authors: Lila A. M. , Parfenov V. A. , Karateev A. E. , Adasheva T. V. , Alekseeva L. I. , Afanasyev V. V. , Barantsevich E. R. , Vorobyeva O. V. , Davydov O. S. , Ekusheva E. V. , Zagrebneva A. I. , Iskra D. A. , Kukushkin M. L. , Rachin A. P. , Filatova E. S. , Churyukanov M. V. , Shirokov V. A.
Published: February 2025

On December 18, 2024, a meeting of the Expert Council was held to discuss approaches to the treatment of non-specific back pain and pain in rheumatic musculoskeletal disorders. It was noted that non-steroidal anti-inflammatory drugs (NSAIDs) remain the mainstay of therapy for inflammation-related pain and that optimal therapy should provide a balance between high efficacy and good tolerability in each patient. A new NSAID, pelubiprofen (Pelubio®), has been registered in the Russian Federation. According to research data, its efficacy is comparable to that of non-selective and selective NSAIDs and at the same time the drug has a high safety profile. The resolution of the Expert Council states that this medicine can be prescribed within the framework of Russian clinical practice, considering the registered indications for pelubiprofen and the clinical guidelines adopted in Russia for the treatment of acute and chronic non-specific back pain, radiculopathy, osteoarthritis (including gonarthrosis and coxarthrosis) and rheumatoid arthritis.