bluuebunny/crossref_metadata_2025 huggingface dataset:
In UteroElectroporated Neurons for Medium-Throughput Screening of Compounds Regulating Neuron Morphology
Authors: Sokolov Aidan M. , Aurich Mariana , Bordey Angélique
Published: August 2023

Several neurodevelopmental disorders are associated with increased mTOR activity that results in pathogenic neuronal dysmorphogenesis (i.e., soma and dendrite overgrowth), leading to circuit alterations associated with epilepsy and neurologic disabilities. Although an mTOR analog is approved for the treatment of epilepsy in one of these disorders, it has limited efficacy and is associated with a wide range of side effects. There is a need to develop novel agents for the treatment of mTOR-pathway related disorders. Here, we developed a medium-throughput phenotypic assay to test drug efficacy on neurite morphogenesis of mouse neurons in a hyperactive mTOR condition. Our assay involvedin uteroelectroporation (IUE) of a selective population of cortical pyramidal neurons with a plasmid encoding the constitutively active mTOR activator, Rheb, and tdTomato. Labeled neurons from the somatosensory cortex (SSC) were cultured onto 96-well plates and fixed at various daysin vitroor following Torin 1 treatment. Automated systems were used for image acquisition and neuron morphologic measurements. We validated our automated approach using traditional manual methods of neuron morphologic assessment. Both automated and manual analyses showed increased neurite length and complexity over time, and decreased neurite overgrowth and soma size with Torin 1. These data validate the accuracy of our automated approach that takes hours compared with weeks when using traditional manual methods. Taken together, this assay can be scaled to screen 32 compounds simultaneously in two weeks, highlighting its robustness and efficiency for medium-throughput screening of candidate therapeutics on a defined population of wild-type or diseased neurons.
Latin American Scholars Home In on Relations with China
Authors: Stallings Barbara , Sanborn Cynthia
Published: August 2023

As China has become a more important actor in Latin America and the Caribbean (LAC), scholars in this region have shown an increasing interest in studying the resulting challenges this poses. Most recent work has centered on economics (trade between China and LAC and finance from China), or on the consequences for environmental, social, and governance issues, although some scholars have focused on the impacts of US – China conflict in the region. In all cases, the question tends to be whether LAC countries are benefiting from the greater Chinese presence or whether problems outweigh the potential gains. We point out the leading research centers and scholars studying these questions and discuss the main debates around them. We conclude with a set of recommendations to improve the quality of research, including the need for better data and more collaboration with Chinese colleagues as well as the importance of transparency about the sources of finance and potential biases in work on this growing area of interest.
The divergence of mutation rates and spectra across the Tree of Life
Authors: Lynch Michael , Ali Farhan , Lin Tongtong , Wang Yaohai , Ni Jiahao , Long Hongan
Published: August 2023

Owing to advances in genome sequencing, genome stability has become one of the most scrutinized cellular traits across the Tree of Life. Despite its centrality to all things biological, the mutation rate (per nucleotide site per generation) ranges over three orders of magnitude among species and several‐fold within individual phylogenetic lineages. Within all major organismal groups, mutation rates scale negatively with the effective population size of a species and with the amount of functional DNA in the genome. This relationship is most parsimoniously explained by the drift‐barrier hypothesis, which postulates that natural selection typically operates to reduce mutation rates until further improvement is thwarted by the power of random genetic drift. Despite this constraint, the molecular mechanisms underlying DNA replication fidelity and repair are free to wander, provided the performance of the entire system is maintained at the prevailing level. The evolutionary flexibility of the mutation rate bears on the resolution of several prior conundrums in phylogenetic and population‐genetic analysis and raises challenges for future applications in these areas.
Assessment of Risks for Gastrointestinal Bleeding in Patients with Brain Injury
Authors: Terehov I. S. , Klicenko O. A. , Bautin A. E. , Tsentsiper L. M. , Kondratyev A. N.
Published: August 2023

The aim of the study was to develop a risk model for upper gastrointestinal tract (GIT) bleeding in patients with brain injury of various etiologies.

Material and methods. Case histories of 33 patients were included into a retrospective descriptive study: 22 patients had severe brain injury of various etiologies, and 11 patients after elective surgery for cerebral aneurisms with uneventful postop period were taken for comparison. The patients were grouped in two arms: Group 1 included patients with obvious signs of GIT bleeding (N=11) and Group 2 had no obvious signs of bleeding (N=22). Complaints, life and medical history, comorbidities, specialists’ exams data, results of laboratory and instrumental examinations, therapeutic regimens were analyzed. Presence of disproportionate pathologic sympathetic overreaction to acute brain injury, i.e., paroxysmal sympathetic hyperactivity (PSH), was assessed on admission and on Days 1, 3 and 5 after brain injury. 

Results. A model for upper GIT bleeding risk assessment was designed using logistic regression. The resulting model gains high quality rating: χ²=33,78, 3; p<0,001; OR=315. The risk of upper GIT bleeding exceeded 95% in patients having combination of 4 symptoms in their medical history (presence of PSH on Day 1 after acute brain injury; Karnofsky performance scale index 75; lack of neurovegetative stabilization in the acute period of brain injury; gastric and/or duodenal ulcer).

Conclusion. Determining the risk factors thresholds enables stratification of patients by the risk for upper GIT bleeding. Modification of the identified four risk factors (presence of PSH on Day 1after acute brain injury; Karnofsky performance scale index 75; lack of neurovegetative stabilization in the acute period of brain injury; gastric and/or duodenal ulcer) will probably reduce the occurrence of upper GIT bleeding in patients with acute brane injury of various etiology.
Quasi-Owen Value for Games on Augmenting Systems with a Coalition Structure
Authors: Tang Jie , Li Zijun , Meng Fanyong
Published: August 2023

This paper focuses on games on augmenting systems with a coalition structure that can be seen as an extension of games with a coalition structure and games on augmenting systems. Considering the player payoffs, the quasi-Owen value is defined. To show the rationality of this payoff index, five representative axiomatic systems are established. The population monotonic allocation scheme (PMAS) and the core are introduced. Moreover, the relationships between the PMAS and quasi-Owen value as well as the core and quasi-Owen value are discussed. Finally, an illustrative example is given to show the concrete application of the new payoff indices.
Caring for Hospitalized Children in Foster Care: Provider Training, Preparedness, and Practice
Authors: Sleppy Rosalie M. , Watson Breanna D. , Donohue Pamela K. , Seltzer Rebecca R.
Published: August 2023

BACKGROUND AND OBJECTIVES

Children and youth in foster care (CYFC) have high rates of health care utilization, including inpatient care. The objective of this study was to explore the inpatient provider experience caring for CYFC.

METHODS

Semistructured interviews were conducted with inpatient pediatric providers from Mid-Atlantic hospitals. Interview questions focused on 3 domains: provider training and preparedness, practice challenges, and strategies to improve care for CYFC. Conventional content analysis was applied to interview transcripts.

RESULTS

Thirty-eight interviews were completed with providers from 6 hospitals, including 14 hospitalists, 1 advanced practice provider, 11 registered nurses, 10 social workers (SWs), and 2 case managers. Nearly all (90%) reported at least monthly interactions with CYFC. Themes related to training and preparedness to care for CYFC included: medical providers’ lack of formal training, limited foster care knowledge, and feeling of preparedness contingent on access to SWs. Themes related to unique practice challenges included: identifying CYFC, obtaining consent, documenting foster care status, complex team communication, and navigating interpersonal stress. Participants’ suggestions for improving their ability to care for CYFC included increasing SW capacity, expanding provider training, standardizing electronic medical record documentation and order sets, and improving team communication and information sharing.

CONCLUSIONS

There are unique medical, social, and legal aspects of caring for hospitalized CYFC; pediatric medical providers receive limited training on these topics and rely heavily on SWs to navigate associated practice challenges. Targeted educational and health information technology interventions are needed to help inpatient providers feel better prepared to effectively meet the needs of CYFC.
PERAN KERANG PENYARING PARTIKEL TERHADAP KERAGAMAN MAKROBENTHOS DI AGGREGASI KERANG
Authors: Ompi Medy , Boneka Farnis B. , Kaligis Erly Y. , Kaunang Stella T.
Published: August 2023

Tujuan penelitian ini adalah untuk mengetahui distribusi jenis, kelimpahan, keragaman, dan kesamaan makrobenthos yang berada di dalam posisi aggregasi di lokasi berbeda.  Observasi telah dilakukan di 2 stasion Tiwoho dan Blongko, selama April, 2021. Makrobentos diambil dengan meletakan ‘Core’ (PVC) dengan diameter 15 cm pada posisi tengah dan pinggir aggregasi besar, serta aggregasi kecil di 2 lokasi.  Materi yang ada di dalam ‘Core’ diangkat, dimasukkan di dalam plastik yang berlabel, selanjutnya disortir, diidentifikasi, dihitung, dan foto di laboratorium.  Pengambilan sampel dilakukan sebanyak 4 kali sebagai ulangan pada posisi aggregasi yang berbeda.  Jumlah jenis dan individu makrobenthos dianalisa dengan menggunakan 2 Arah ANOVA, di mana posisi dalam aggregasi dan stasion adalah sebagai faktor utama.  Mengetahui keragaman dilakukan melalui perhitungan Indeks ‘Simpon’ dan kesamaan dengan Indeks ‘Evenness’.  Hasil menunjukkan bahwa jumlah jenis dan jumlah individu (kelimpahan) makrobenthos bervariasi di antara posisi dalam aggregasi kerang, namun tidak dipengaruhi oleh baik posisi dalam aggregasi dan stasion.  Keragaman dan kesamaan jenis makrobenthos dikategorikan tinggi, walaupun baik ‘Indeks Simpson’ dan ‘Evenness’ bervariasi dan tidak konsiten di antara posisi dalam aggregasi dan stasion.  Jumlah individu (kelimpahan) makrobenthos nampak bebeda di antara posisi aggregasi di lokasi Blongko berdampak pada perbedaan stabilitas makrobenthos untuk kedua lokasi.
A technique for measuring the plane-wave reflection coefficient of the ocean bottom
Authors: Frisk George V. , Oppenheim Alan V. , Martinez David R.
Published: August 2023

A new technique for the measurement of the plane-wave reflection coefficient of a horizontally stratified ocean bottom is described. It is based on the exact Hankel transform relationship between the reflection coefficient and the bottom reflected field due to a point source. The method employs a new algorithm for the numerical evaluation of the Hankel transform which is based on the "projection-slice" theorem for the two-dimensional Fourier transform. The details of the algorithm are described in the companion paper. Although the algorithm is applied to the case of an isovelocity ocean, the general theory for measuring the plane-wave reflection coefficient in a refracting ocean is developed. The technique provides information about the reflection coefficient, not only for real incident angles, _but also for complex angles, thus potentially providing substantial additional structural information about the bottom. The method is shown to yield excellent results with synthetically generated data for the cases of a hard bottom and slow isovelocity bottom.
La ética en la Inteligencia Artificial
Authors: Zabala Leal Tatiana Dulima
Published: August 2023

Este escrito pretende relacionar algunas razones por las cuales se considera importante tener presente la ética como piedra angular en la implementación de la Inteligencia Artificial (IA) y sus productos, para ello, se relacionarán las posturas de algunos autores expertos y organismos internacionales respecto de los riesgos de la automatización de esta y los potenciales efectos de sus productos. De igual forma, se abordará el transhumanismo como un mecanismo que propende por la optimización de la calidad de vida de los seres humanos, pero siempre bajo el acatamiento de los derechos humanos y su dignidad.
Trabajo Decente
Authors: Molero-Suárez Lisbeth Marina , Venegas-Camargo Allynson Karen , Gamboa-Molano Carlos Felipe , Benavídez-Morales Luz Ángela , Torres-Pinto Leidy Stefany , Velazco-Rodríguez Magdiel
Published: August 2023

Para la Organización Internacional del Trabajo (OIT, 2014), el trabajo decente se equipara a las diferentes oportunidades presentes en la productividad y a las aspiraciones que poseen los individuos en su actividad laboral, no obstante, en muchas circunstancias dichas aspiraciones se ven atropelladas, de ahí que las empresas en conjunto con sus empleados asuman posturas de resiliencia y adaptabilidad. Ahora bien, las pequeñas y medianas empresas y el mercado de trabajo, por la situación de la pandemia, se han deteriorado a nivel global y regional, generando insatisfacción, deterioro económico y desmotivación, lo que repercute en el trabajo decente. De ahí que se evidencie un aumento en el desempleo, donde el trabajo digno con ingresos atractivos pasa a un segundo plano. Para la Dirección General de la OIT (2012) la pandemia cambió lo que previamente se había planificado; la productividad laboral se ve afectada perdiéndose el derecho del trabajador, protección familiar debilitada. El libro dispone un acercamiento a las pymes en la ciudad de Bogotá desde la perspectiva del trabajo decente pretende mostrar en medio de un contexto adverso las estrategias que permiten a los individuos desarrollarse y mantenerlos protegidos en este entorno empresarial con características limitadas. El trabajo decente ha sido objeto de muchas investigaciones, sin embargo, en lo que respecta a este tipo de estructura organizacional son escasos los acercamientos hechos para conocer su situación actual.
Three amazing new species of the genus Chrysolina (Coleoptera: Chrysomelidae: Chrysomelinae) from China
Authors: Bienkowski Andrzej O.
Published: August 2023

Three new species of the genus Chrysolina Motschulsky, 1860, namely Сh. caspari sp. n., Ch. melchiori sp. n., and Ch. balthazari sp. n. are described from Sichuan and Yunnan Provinces of China. These species have rare or unique features. In Ch. caspari sp. n. the shape of the last maxillary palpomere (it is shorter and narrower than the penultimate one) is a rare case in the genus Chrysolina. Among Chinese species, this shape of maxillary palpi is known only in one species, Ch. pieli Chen, 1936. In Ch. melchiori sp. n. the relief of elytral surface (strongly reticulated irregular funnels bearing a puncture at the bottom, separated by smooth intervals) is unique for the genus Chrysolina. In Ch. balthazari sp. n. the relief of elytra (alternation of wide convex intervals between pairs of rows and very narrow flat or slightly convex intervals between rows of one pair) is well distinguishable from most Chrysolina members. Due to this feature, the new species can only be close to Ch. jinxiaoae Ge in: Daccordi, Ge, Cui, Yang, 2011 from North Sichuan. Photographs of habitus, external characters, and male aedeagi are presented.
Anaerobik Eşik ve Anaerobik Güç İlişkisinin Kalp Atım Hızı Değişkenliğinin Non-invazif Değerlendirilmesi
Authors: ALPARSLAN Tuncay , ARABACI Ramiz , KÜÇÜK Nuran , GÜNGÖR Ali Kamil
Published: August 2023

Bu araştırmanın amacı anaerobik eşik (AE) ve anaerobik gücün (AG) kalp-atım-hızı-değişkenliği (KAHD) açısından test-öncesi, test-sırası ve sonrası değerlerle değişimi arasındaki farklılığın ve AE ile AG’nin KAHD parametreleri arasındaki ilişkinin incelenmesidir. 25 sağlıklı erkek gönüllü olarak araştırmaya katıldı (Ort. yaş=24±0,9 yıl; boy=177,5±6,2 cm; ağırlık=80,4±8,3 kg). İlk gün boy, ağırlık ve vücut kompozisyonu ölçümü yapıldı. Wingate anaerobik kapasite testi uygulandı. Test-öncesinde (30 saniye), test-sırasında (30 saniye) ve test-sonrasında (30 saniye) KAHD için kayıt alındı. İkinci gün kardiyo-pulmoner egzersiz testi Bruce protokolü uygulandı. Test başlamadan önce (30 saniye), test süresince ve test bitiminde (30 saniye) KAHD kaydı alındı. Ön-test, test ve son-test için katılımcıların KAHD parametrelerini karşılaştırmak için tekrarlanan varyans analizi (ANOVA) kullanıldı. Grup içi karşılaştırmalar Bonferroni testi ile belirlendi. AE ile AG ilişkisi için Pearson korelasyon katsayısı belirlendi. Araştırma verilerinin analizi sonucunda AE ve AG için MeanRR için test-öncesi, test-sırası ve sonrasında anlamlıdır (p<0,001). SDNN için değişim AG ölçümünde test-sırası, test-sonrası (p<0,05) ve test-öncesi, test-sonrası (p<0,01), RMSSD için ise sadece AE bölgesinde test-öncesi, test sırası ve test-öncesi, test-sonrası arasında anlamlıdır (p<0,001). LFnu (p<0,05) ve HFnu (p<0,01) için test-öncesi ile test-sırası arasında anlamlı değişim görülmüştür. AE ile AG arasında ise KAHD parametrelerinden sadece LF/HF için anlamlı pozitif ilişki söz konusudur. Bu araştırma sonuçlarına göre AE ile AG için KAHD test-öncesinden başlayarak test-sırasında ve test-sonrasında artarak düşmeye devam etmekte olup test-sonrasında toparlanma sağlanamamaktadır. AE ile AG arasında KAHD değişimleri arasındaki ilişki sadece LF/HF için pozitif yönde anlamlıdır. AE ile AG, KAHD parametrelerinin düşüşü açısından benzerlik gösterse de tam olarak birbiriyle ilişkili olduğu söylenemez.
Outpatient Oncology Fall Risk: A Quality Improvement Study
Authors: Hammontree Stephanie , Potts Maryellen , Neiberger Adam , Olds Danielle , English Daniel , Myers Jamie S.
Published: August 2023

Introduction. Patients receiving cancer treatment are at high risk for falls. No current guidelines or standards of care exist for assessment and prevention of outpatient oncology falls. This quality improvement project’s purpose was to 1) describe and evaluate outpatient oncology falls data to determine root cause(s) and develop, implement, and evaluate intervention strategies for future policy refinement, and 2) compare fall rates pre/post implementation of a system-wide Ambulatory Fall Risk Bundle.
Methods. Retrospective data were used to describe and categorize fall incidence for the University of Kansas Cancer Center over 12 months. Further analyses were conducted to describe fall rates per 10,000 kept appointments pre/post implementation of an Ambulatory Fall Risk Bundle protocol. Semi-structured interviews were conducted with medical assistants and nurse managers to evaluate the initiative’s impact, staff satisfaction, and recommendations for refinement.
Results. The initial 12-month assessment yielded 58 patient falls retained for further analyses. Most patients were receiving chemotherapy (79%). Common contributing symptoms included dizziness/faintness and weakness (43%). Tripping/falling over a hazard (24%) and falls during transfer (5.8%) also were cited. Subsequent analyses of fall rates per 10,000 kept appointments pre/post implementation of the Ambulatory Fall Risk Bundle indicated no change. Recommendations from the qualitative interviews included: orthostatic vital sign protocol implementation, redesign of the electronic medical record fall risk alert, stakeholder involvement in protocol development and related education, and additional assistive devices/equipment. 
Conclusions. System-related policy and culture change, investment in physical and human resource enhancements, and evidence-based protocols are needed to improve outpatient oncology fall rates.
ПРАВО АВТОРА НА САМОЦИТИРОВАНИЕ СРЕДИ ДРУГИХ АВТОРСКИХ ПРАВ
Authors: ЗАЙЦЕВ Владимир Васильевич , МИХАЙЛОВА Ирина Александровна
Published: August 2023

В статье анализируются проблемы, связанные с воспроизведением в научных работах фрагментов ранее опубликованных исследований, получившим наименование «самоцитирование», или «самоплагиат». Исследуя правовую сущность права на такое воспроизведение, авторы доказывают, что оно является личным неимущественным правом, вытекающим из содержания конституционного права на свободу литературного, художественного, научного, технического и других видов творчества.      

С введением тотальной проверки уровня оригинальности представленных научных произведений содержащиеся в них фрагменты ранее опубликованных работ расцениваются как «заимствованные», что становится препятствием к допуску диссертаций к защите. По мнению авторов, отрицание возможности использования в диссертации отрывков из ранее опубликованных работ означает, что от соискателя требуется проведение нескольких исследований: в виде диссертации и в форме научных статей, относящихся по содержанию к избранной проблематике, что противоречит логике научного исследования и отрицательно сказывается на его результатах.

Много внимания уделяется характеристике использования автором фрагментов собственных текстов в научных статьях и монографиях без ссылок на первоисточник, которое нарушает положение, закрепленное в п. 1 ст. 1274, нормы научной этики и лишает читателей возможности сопоставить первоначальный и представленный авторские тексты и выявить в последнем наличие или отсутствие новизны.  

Проанализировав представленные в современной доктрине суждения относительно рассматриваемого правомочия, авторы формулируют следующие выводы: во-первых, о лексическом несоответствии его характеру термина «самоплагиат», в связи с чем предлагают именовать такое воспроизведение «недобросовестным самоцитированием»; во-вторых, об отсутствии недобросовестности автора во всех случаях, когда воспроизведенные им фрагменты прежних работ сопровождаются указанием на первоисточник. Доказывается, что в большинстве случаев такое воспроизведение свидетельствует не о недобросовестности автора, его лени или желании ввести читателей в заблуждение, а о его научной последовательности, преданности отстаиваемым научным идеям и о стремлении привлечь к ним новых сторонников.
A substance with negative mass
Authors: BG Golovkin
Published: August 2023

The conditions for the formation of a substance with a negative mass are investigated. The critical velocity of a body ω = 235696.8871 km/s, necessary for its transition to a massless state, was determined by two independent methods. Zeroing of the mass of matter also occurs at a temperature T =2.17 . 1036 mo (mo is the rest mass of the particle in grams). At higher temperatures or speeds of movement, the mass of bodies becomes negative. The resulting formulas made it possible to calculate the masses of X,Y-bosons equal to 4.606 . 10-9 g. The temperature of the Superunification of the four fundamental interactions, including gravity, is estimated to be 4.72 . 1031 K.
The Experience of Value. The Influence of Scheler on Sartre’s Early Ethics
Authors: Vidali Cristiano
Published: August 2023

Jean-Paul Sartre is often portrayed as a philosopher whose ethics would inevitably have subjectivist or relativist outcomes. Yet, even in Sartre’s early works there are several stances that blatantly belie this image, relying rather on an objectivist conception of value that he notably draws from Max Scheler. The aim of this paper is thus to investigate the influence of Scheler’s moral reflection on Sartre, arguing how it can represent an original and fruitful starting point to approach Sartrean ethics. To this aim, we will first report on and discuss some passages from Sartre’s early works where this debt is most noticeable. Then, we will provide an overview of the Schelerean legacy, arguing how it represents for Sartre the very opening of the ethical issue addressable in phenomenological terms, avoiding the dead end of Hume’s and Kant’s more classical positions, while at the same time being consistent with other peculiar themes of Sartrean philosophy, namely existence and historicity.
PREKAST ÖNGERME KİRİŞLİ KÖPRÜNÜN YAPIM AŞAMALARI DİKKATE ALINARAK ZAMAN TANIM ALANINDA DOĞRUSAL OLMAYAN ANALİZ YÖNTEMİYLE PERFORMANSININ BELİRLENMESİ
Authors: ÇAVDAR Özlem , SARIGÜN Osman
Published: August 2023

Mühendislik yapılarının tasarımında gerekli olan yapısal çözümlemelerin gerçekçi sonuçlar verebilmesi için tasarım aşamasında yapının inşa aşaması, süresi ve yapıya esas beton, çelik gibi malzemelerin bu süre zarfında meydana gelecek değişimleri ile beraber dinamik etkilerin de dikkate alınması gerekmektedir. Çalışma kapsamında karayolu köprüsünün uygulama modeli üzerinde gerçekleştirilecek sonlu eleman analizleriyle yapı tasarımlarının sadece servis durumu ve yapım aşamalarını dikkate alacak şekilde değil, zaman tanım alanında gerçek ivme kayıtlarının da kullanılarak dinamik çözümlenmesi gerekliliği amaçlanmıştır. Model olarak seçilen Çirmiş Köprüsü üç eşit açıklığa sahip olup toplam 96 metre uzunluğundadır. Köprü üst yapısı, tabliye ve öngerme kirişlerden oluşmaktadır. Bu tip köprülerin tasarım esaslarında kullanılan AASHTO, TS 3233 Yönetmelikleri ve TCK Yol Köprüleri Teknik Şartnamesi dikkate alınarak köprü üst yapısının model güvenilirliği sağlanılıp çözümlemelere başlanılmıştır. Dinamik etkilerin tespiti amacıyla TBDY-2018 kapsamında belirtilen kurallar çerçevesinde gerçekleştirilen zaman tanım alanında doğrusal olmayan yapım aşamalı analiz ile doğrusal olmayan yapım aşamalı analiz sonuçları karşılaştırılmıştır. Zaman tanım alanında doğrusal olmayan yapım aşamalı analiz sonuçlarının yapı elemanlarında daha yüksek kesit tesirleri ve yer değiştirme değerleri verdiği gözlemlenmiştir. Ülkemizin aktif fay kuşağında yer almasından dolayı yapı tasarımlarının, zaman tanım alanında gerçek ivme kayıtlarının da kullanılarak dinamik çözümlenmesi gerekmektedir.
Cyanobacteria growth v1
Authors: M. Borges Ricardo
Published: August 2023

Este documento apresenta o protocolo para cultivar cianobactérias em água salgada, incluindo informações detalhadas sobre as soluções, cálculos e volumes necessários para o processo. É importante observar que as taxas de crescimento de diferentes espécies de cianobactérias podem variar significativamente. This document outlines the protocol for cultivating cyanobacteria in saltwater, including detailed information on the solutions, calculations, and volumes required for the process. It is essential to note that the growth rates of different cyanobacteria species may vary significantly.
Assocation of serum galectin-3 levels with survival and cardiovascular disease in dialysis patients: a systematic review and dose-response meta-analysis v1
Authors: Bellos Ioannis , Benetou Vassiliki
Published: August 2023

The present systematic review and meta-analysis aims to determine the association of serum galectin-3 levels with the risk of mortality and cardiovascular disease among patients undergoing maintenance dialysis. The outcomes of interest will include mortality (all-cause and cardiovascular), major adverse cardiovascular events, as well as measures of arterial stiffness and echocardiographic parameters. The risk of bias of the included studies will be assessed using the ROBINS-I tool. A dose-response meta-analysis approach will be implemented to define a potential exposure-response association between serum galectin-3 levels and mortality risk.
Reforming narratives on human sexuality in the Dutch Reformed Church
Authors: Van der Riet Louis
Published: August 2023

This article offers a critique on the dominant narrative on human sexuality in the Dutch Reformed Church (DRC). A mirror is held up to the binary nature of this dominant discourse, centred on ethics, hermeneutics, and ecclesiology. The limitations of how the DRC has engaged with human sexuality, and homosexuality in particular, are framed within the church’s own construction of being “vasgeloop” (stuck) amidst plurality and diversity. These limitations are discussed as issues of church unity, justice, and embodiment. Finally, a subaltern “window” is offered out of this apparent impasse, that looks upon the liberating alternatives presented by embodied queer narratives. In an attempt at seeing queerness within the Reformed tradition, queer phenomenology is presented as an epistemic shift away from the normative, binary discourse that has dominated the discourse on human sexuality in the Dutch Reformed Church.
Thermal Fatigue FE Analysis of Brake Disc under Different Parameters
Authors: Ashish R. Pawar, Dattatray P. Kamble Kashinath H.Munde, Ganesh E. Kondhalkar,
Published: August 2023

A brake is the most important part of a vehicle necessary for good control of vehicle to avoid accidents. Brakes are required to stop the vehicle within minimum possible distance and it is done by converting kinetic energy of the vehicle into heat energy by friction which is dissipated into atmosphere. Most important requirement of brakes is that they should have good anti fade, anti-wear properties & ability to withstand large temperature generated during braking. Due to generation of heat by rise in temperature during braking, thermal fatigue failure of brake can occur which hampers normal braking of vehicle. So it is necessary to analyze thermal behavior of disk under elevated temperature to get optimum design of disc. Objective of this paper is to Compare thermal behavior of solid disk i.e. disk without hole and then disk with hole using FEA approach which can assist in disc rotor design and analysis to avoid thermal damage of disk brake.
Review Paper on Solar Still with Bitumenasa Phase Change Material for Water Distillation
Authors: Ganesh E. Kondhalkar, Dhanashree S. Ware Mahesh P. Kumbhare, Vikas K. Mehtre,
Published: August 2023

Water is basic necessity of man. Fresh water sources are considered to be rivers, lakes and underground water reservoirs. Although, more than two-third of the earth is covered with water and remaining of the earth is land. However, the use of water from such sources is always not good, because of the polluted environment. In present work phase change material(Bitumen) is used to store the solar thermal energy in the form of latent heat, which can offer high storage capacity per unit volume and per unit mass and we can get heat in the night time for desalination. The efficiency of the solar still without PCM is about 25.19% and in presence of PCM (Bitumen) will rises.
Mechanical Analysis Carrired out to a Single Basin Solar Still Integrated with Nano -Composite PCM
Authors: Ganesh E. Kondhalkar Et al.
Published: August 2023

In this article, thermal modeling of a single basin solar still coupled with an evacuated tube solar collector under natural circulation mode has been carried out on the basis energy balance equations. The expressions of inner surface of glass cover, outer surface of glass cover, basin liner, and water mass have been derived for the numerical computation. The experiments were conducted under various meteorological conditions for 0.05 m water depth. This experimental setup has been installed at Solar Energy Park, Tamilnadu College of Engineering, Coimbatore, India (Latitude: 11?N; Longitude: 77?E; and an altitude of 409 m above sea level). Observation revealed that there was a considerable increase in the average daily yield of solar still when integrated with an evacuated tube solar collector. For all the cases, the correlation of coefficients (r) between theoretical and experimental values have been verified and they showed good agreement with 0:98 < r < 0:99 and root mean square present deviation of 10:26 < e < 39:7%.
Conventional magnetic resonance imaging of peripheral nerves: MR-neurography
Authors: Morozova Sofya N. , Sinkova Viktoriya V. , Grishina Darya A. , Tumilovich Taisia A. , Chechetkin Andrey O. , Krotenkova Marina V. , Suponeva Natalya A.
Published: August 2023

Peripheral neuropathy is known to be one of the most common neurological disorders. Despite the great diagnostic value of electroneuromyography and ultrasound, addressing the diagnostics and differential diagnostics of peripheral nerve diseases of different origin could be challenging. In recent years, magnetic resonance tomography has been increasingly used for evaluating cases of suspected or established peripheral neuropathy with excellent results.
This manuscript mainly deals with the advantages and limitations of the aforementioned diagnostic instruments, technical considerations according to different anatomy of peripheral nerves, along with state-of-the-art technical decisions, frequently used magnetic resonance imaging sequences and their diagnostic value based on own observation, and recommendations for contrast enhancement use and different methods of fat suppression.
Currently, there is practically no standardized description of normal magnetic resonance imaging features of peripheral nerves, as well as their changes in different diseases. The evaluation of images is mainly based on the radiologist experience, which obviously decreases methods diagnostic value. Studies of large numbers involving healthy volunteers and patients with peripheral neuropathies of different origin are required to address this issue.
Nonimmune binding of human immunoglobulins G and A by Streptococcus pyogenes: the role of this phenomenon in pathology
Authors: Burova Larisa A. , Suvorov Alexander N. , Pigarevsky Peter V. , Totolian Artem A.
Published: August 2023

M and M-like proteins are key pathogenicity factors of Streptococcus pyogenes, a widely prevalent and potentially lethal bacterium. These proteins confer resistance to the hosts innate and adaptive immune response by attracting specific human proteins to the streptococcal surface. The nonimmune binding of host immunoglobulins G (IgG) and A (IgA) to M and M-like proteins via their Fc domains was first described over 50 years ago, but its role in the pathogenicity of S. pyogenes remains unclear. This discovery has had a significant impact on the development of innovative diagnostic approaches, technologies, and tools in microbiology, immunology, and molecular biology. The nonimmune binding of immunoglobulins has been suggested to play a role in immune conditions on mucosal surfaces and their secretions, but not in blood plasma, while other studies suggest it protects microbes from phagocytosis in the hosts nonimmune blood. The Fc-binding effect has been shown to increase the pathogenicity of streptococci, contributing to the development of autoimmune diseases and tissue damage in experimental animals. The experimental autoimmune process can be prevented by administering purified Fc fragments of immunoglobulins to animals. Streptococcal diseases play a significant role in the pathogenesis of IgA-nephropathy (IgAN), a mesangial proliferative process caused by initial IgA-Fc deposition in renal mesangium cells. Literature suggests a relevance of recent ideas about the important role of nonimmune Ig binding in streptococcal diseases, and further efforts are required to study the binding of Fc fragments of IgG and IgA to M and M-like proteins of S. pyogenes, with the aim of developing preventive and potentially therapeutic applications. The paper speculates on the role of nonimmune Ig binding in streptococcal diseases, including cases with various mechanisms of development. These studies also focuses on preventive and potentially therapeutic applications of Fc fragments of IgG to M or M-like proteins of S. pyogenes.
RELATIONSHIP BETWEEN QUIET QUITTING AND LEADERSHIP ORIENTATION: THE CASE OF CROATIAN EMPLOYEES
Authors:   University of Split, Faculty of Economies, Business and Tourism, Split, Croatia, Bakotić Danica
Published: August 2023

Quiet quitting describes the situation when an employee mentally and emotionally checks out form the job, and does the bare minimum in her/his everyday work activities. This topic becomes very popular since the coronavirus pandemic, when people reconsidered their approaches towards work and decided to accomplish work-life balance. Quiet quitting is mostly evident among generation Z and Millennials, but other generations are also involved in this phenomenon. In general, quiet quitting origins from an organization's failure to create a meaningful bond with its employees. Consequently, leadership orientation could influence on appearance and presence of quiet quitting behaviour. The aim of this paper was to examine the phenomenon of quiet quitting among Croatian employees. An additional aim was to analyse the connection between quiet quitting and leadership orientation. The empirical research was conducted in 2023 on convenience sample. The questionnaire was created and distributed online. Research results showed a moderate level of quiet quitting behaviour among Croatian employees. Furthermore, research results suggested that task oriented leadership is more often represented than people oriented leadership. A negative statistically significant correlation between task oriented leadership and quiet quitting has been discovered, but no statistically significant correlation between quiet quitting and people oriented leadership.
A critical review on kasa (cough) in children
Authors: Sahane Sonali B. , Rathi Renu B.
Published: August 2023

In the Ayurvedic classics, Kasa (cough) is considered as an independent disease. It may also occur as Lakshana (symptom) or Upadarava (complication) in other diseases. It is an example of Pranavaha Srotas Dushti Kasa is common signs and symptom in the childhood, when mother and father see a doctor. It suggests that even after improvements in modern scientific science, coughs in children are not always treated effectively. According to Acharya Charaka, the Moola of Pranavaha Srotas is Hridya (brain, heart) and Mahasrotas. Acharyas have described definition, etiological factors, prodromal symptoms, types of Kasa along with all Pathya (wholesome) and Apathya (unwholesome) and therapeutic measures. Kasa is manifested with the vitiation of Vata and Kapha. Understanding and differentiating Kasa is important for its effective treatment. The study of Kasa is necessary as it can be associated with many complications if left untreated. In this context different Lakshanas (symptoms) of Kasa in children are explained by Acharyas which can be used for diagnosis as well as prognosis of the disease. Thus, with help of this study alternate safe methods of treatment in children can be employed. So, its identification as Kasa can be a ray of hope for the diagnosis.
Endoscopic coblation adenoidectomy and conventional adenoidectomy: a comparative study
Authors: V. Shilpa , M. Suresh Kumar , Parameswaran Gopakumar
Published: August 2023

Background: Adenoidectomy is most common paediatric surgical procedures. Commonly used methods for adenoidectomy are conventional curettage adenoidectomy and endoscopic coblator assisted adenoidectomy. The technique of coblation adenoidectomy has considerable influence on the duration of surgery, the blood lost intra operatively, pain on the first postoperative period.
Methods: Sample selected for study were children of age group 3 to 11 years attending ENT OPD with clinical signs of adenoid hypertrophy, who underwent adenoidectomy during the time period from October 2019 to June 2021. We compared the efficacy of ECA with CCA based on the intra-operative (operative time and bleeding) and post-operative parameters (pain on the first post operative day).
Results: Our study revealed that intra operative bleeding was more in CCA compared to ECA (p<0.001). ECA took more operative time than CCA group (p<0.001). Pain on the first post-operative day was more in CCA than ECA.
Conclusions: Primary objective was comparison of intra operative bleeding among both groups and the outcome was blood loss in ECA was less than CCA. Secondary objective was comparison of operative duration and pain on the first post-operative day and the outcome was, operative duration was less in CCA and pain in the first post-operative day was more in CCA. Our conclusion is that ECA was efficient on the basis of intra operative blood loss and post- operative pain in the first day. CCA was effective in operative duration.
Effectiveness of Epley's maneuver alone without any drugs in the treatment of posterior canal benign paroxysmal positional vertigo: a prospective analytical study
Authors: George Josna J. V., M. V. , T. Lhsan A.
Published: August 2023

Background: Posterior canal benign paroxysmal positional vertigo (p-BPPV) is the most common peripheral vestibular problem. Many doctors use three treatment options for p-BPPV: drugs alone, Epley’s maneuver with drugs, and Epley’s maneuver alone. Many studies say that Epley’s maneuver with drugs improves the condition much more effectively than drugs alone. Our study is intended to assess the effectiveness of Epley’s maneuver alone in treating posterior canal BPPV.
Methods: A prospective analytical study was performed on 102 patients who were divided into 2 groups after random sampling. Group I underwent repeated applications of Epley’s maneuver alone, and group II underwent a single Epley’s maneuver along with drugs. The data were collected systematically with the help of a proforma and dizziness handicap inventory (DHI) score chart. The patients were reviewed after 24 hours, 1 week, and 1 month.  
Results: In our study, the mean pre-treatment DHI score of group I was 66.71, and group II was 64.39. After 24 hours, the DHI score came down to 46 and 47.61 respectively, and after 1 week and 1 month, it decreased to 33.06 and 22.86, respectively in group I and group II, it came to 44.71 and 38.78, respectively. The difference in mean DHI score between groups I and II is statistically significant, with each review having a p value of 0.00.
Conclusions: This study was able to demonstrate the efficacy of Epley's maneuver in the treatment of BPPV without any drug.
A rare case of second branchial fistula with two external openings
Authors: M. Muniraju , Goel Tanubha
Published: August 2023

Branchial apparatus was first described by Von Baer, but Von Ascheron was the one who described the anomalies in its development. The branchial cyst, sinus and fistula are anomalies of the branchial apparatus which consists of five mesodermal arches separated by invagination of ectoderm (clefts) and endoderm (pouch). Here we present a case of bilobulated second branchial fistula which had both openings over the skin of right anterolateral aspect of the neck. A seven years old girl, presented to ENT OPD, complaining of swelling on right side of the neck associated with discharge from an opening over the swelling since birth. The swelling was painless, progressively increasing in size. Her mother revealed that she had occasionally had a clear discharge from the openings since birth. On examination, dumbbell shaped cystic swelling approx. 5×2 cm in size with two pinhead openings on both the ends, noticed along the anterior border of SCM over the middle third of the neck. Radiological and histopathological investigations confirmed the diagnosis of second branchial fistula. Patient was managed with complete surgical excision. Second branchial anomalies present along the anterior border of sternocleidomastoid. Fistulous tract commonly extends into the pharynx, most commonly in the region of tonsillar fossa. This case report describes a congenital anomaly for which the definitive treatment was surgery. Unlike, other complete second branchial fistula it had two external openings and it was a bilobulated tract, which makes this case a rare variety of branchial fistula
Study of clinicodermoscopic features of topical steroid damaged face patients
Authors: Kushwah Sunayana , Namdeo Chaitanya , Bhatia Kailash
Published: August 2023

Background: Topical steroid dependent or damaged face is an alarming upcoming entity rampant in India due to over-the-counter availability of topical corticosteroids containing products. The present study aimed to study the clinical and dermoscopic changes in patients with topical steroid damaged face and to correlate them with potency and duration of application of the TCS.
Methods: 80 patients visiting the dermatology OPD & IPD at SAIMS Hospital & PG Institute, Indore, with the chief complains of redness, itching, red raised lesions, burning, swelling, photosensitivity, pigmentation; with a history of application of topical corticosteroids of any potency on face for continuous 7 days or intermittent for 15 or more days were enrolled for the study.
Results: Mean age of the patients was 31.5±8.13 years. Male to female ratio was 1:9. Twelve (15.2%) patients abused TCS for more than one year. Presenting complains of the patients were redness (82.5%), itching (66.3%), hypertrichosis (47.5%), pigmentation (66.3%), burning (38.8%) and acne (28.8%). The most common dermoscopy findings i.e., unpatterned brown pigmentation (86.3%), polygonal vessels (73.8%), fine scales (52.5%), hypertrichosis (53.8%), follicular plugs (32.5%), micropustules (15%) and ivory patches (11.3%) were observed in a statistically higher proportion of cases dermoscopically
Conclusions: Dermoscopy in TSDF can help dermatologists in a multitude of ways from confirming the diagnosis to differentiating from other causes of red face and predicting the approximate duration of TCS abuse.
Study of effect of oral itraconazole with 2% sertaconazole cream versus oral terbinafine with 2% sertaconazole cream in dermatophytosis
Authors: Sharmeen Ayesha , Amin Syed Suhail , Adil Mohammad , Varshney Iti
Published: August 2023

Background: Dermatophytosis is a common dermatological problem. Recent studies have reported an increase in the prevalence of the disease. Management of dermatophytosis thus has become challenging for both dermatologists and patients due to their resistance to treatment and their refractory nature. Currently the management of dermatophytic infection includes both oral and topical antifungals. The study compared the clinical efficacy and adverse effect profile of systemic with topical drugs.
Methods: Patients were randomly divided into two groups of 90 each. They were given oral Itraconazole 100 mg twice daily with Sertaconazole 2 % cream twice daily (Group A) and oral Terbinafine 250 mg once daily with Sertaconazole 2 % cream twice daily (Group B) till complete resolution of lesions or a maximum of six weeks. The response was assessed by the improvement in signs and symptoms of each of the clinical parameter, pruritus, erythema, scaling.
Results: At week 6, mycological cure was seen in 92.9% in Group A as compared to 86.9% of patients in Group B. There was a significant improvement in percentage change in pruritus, erythema, and scaling in both the groups from 0 to 6 weeks (p-value: <0.0001). Mild adverse effects such as gastrointestinal upset, headache, and raised transaminases were observed which were comparable in both the groups.
Conclusions: On comparison of the groups, we observed that both were effective but Itraconazole with Sertaconazole 2% cream was more efficacious in terms of both clinical (pruritus, scaling, and erythema) and mycological cure.
Eosinophilic fasciitis with elevated inflammatory markers: another clue
Authors: Riojas-Hernández Edith Dariela , Chavez-Álvarez Sonia
Published: August 2023

Eosinophilic fasciitis is a rare condition characterized by edema, induration, thickening of the skin and soft tissues, hypergammaglobulinemia and peripheral eosinophilia. We present two patients with eosinophilic fasciitis and no elevation of eosinophils at the time of diagnosis.