bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling laser-induced incandescence of Diesel soot—Implementation of an advanced parameterization procedure applied to a refined LII model accounting for shielding effect and multiple scattering within aggregates for $${\varvec{\alpha}}_{{\varvec{T}}}$$ and $${\varvec{E}}\left( {\varvec{m}} \right)$$ assessment
Authors: Lemaire Romain , Menanteau S.
Published: September 2021

An extensive set of LII signals measured in a Diesel spray flame has been simulated using a refined LII model built upon a comprehensive version of soot heat- and mass-balance equations. This latter includes terms standing for saturation of linear, single- and multi-photon absorption processes, cooling by sublimation, conduction, radiation and thermionic emission in addition to mechanisms depicting soot oxidation and annealing, non-thermal photodesorption of carbon clusters as well as corrective factors allowing considering shielding effect and multiple scattering (MS) within aggregates. A complete parameterization of the so-proposed model has been achieved by means of an advanced optimization procedure coupling design of experiments with a genetic algorithm-based solver. Doing so, the values of different factors involved in absorption and sublimation terms have been assessed for a 1064-nm laser excitation wavelength including the multi-photon absorption cross section for C2 photodesorption and the saturation coefficients for linear- and multi-photon absorption, among others. This parameterized model has then been demonstrated to effectively reproduce signals measured in different combustion media including a CH4/O2/N2 premixed flat flame and a diffusion ethylene flame. As a result of the data derived from the analysis of the Diesel flame, a thermal accommodation coefficient value of 0.49 has been assessed against 0.34 when neglecting the shielding effect. In addition, values of the soot absorption function ($$E\left( m \right)$$

E

m

) comprised between 0.18 and 0.31 have been inferred depending on the particle maturation stage. On the other hand, $$E\left( m \right)$$

E

m

24% higher on average have been estimated when neglecting MS thus illustrating the importance of aggregate characteristics on soot properties derived through LII modeling. Eventually, the $$E\left( m \right)$$

E

m

evolution observed herein has been compared with results issued from studies conducted with varied hydrocarbons which led to highlight the crucial role played by the soot maturity level over the nature of the burnt fuel as far as optical properties are concerned.
PD-L1 (SP142) testing is concordant between Benchmark Ultra and Bond-III stainers
Authors: Compérat Eva , Oszwald André , Wasinger Gabriel , Wacquet Justine , Rouprêt Morgan , Cussenot Olivier
Published: September 2021

Background

Atezolizumab is an inhibitor of programmed death-ligand 1 (PD-L1), used to treat advanced or metastatic bladder cancer, and in trials for non-invasive disease. In order to be eligible for treatment, patients require a PD-L1 immune cell score ≥ 5%, using the Ventana SP142 PD-L1 assay. Many laboratories do not have access to the required Ventana Benchmark Ultra stainer, and it is unclear if the assay performs similarly on other stainers. In this study, we compare SP142 assay results between Ventana Benchmark Ultra and Leica Bond-III stainers.

Methods

Serial sections of 90 samples of transurethral bladder resections (comprising 51 pTaHG, 8 pTis, 18 pT1, 10 pT2 tumors) were stained using the SP142 PD-L1 antibody on Ventana Benchmark Ultra and Leica Bond-III stainers, manually scored, and compared using accuracy and Cohen’s kappa measures.

Results

Both devices yielded highly concordant PD-L1 immune cell scores (accuracy 0.84, Cohen’s κ 0.732). Moreover, we found similar tumor cell (TC) PD-L1 scores using both stainers, and a trend towards greater TC scores in pT2 stage samples (p = 0.05).

Conclusion

This study is the first to compare the SP142 antibody in bladder cancer on two different stainers. Our results indicate that both Benchmark Ultra and Bond-III stainers yield highly concordant results using the SP142 PD-L1 antibody.
Adaptive kernel selection network with attention constraint for surgical instrument classification
Authors: Hou Yaqing , Zhang Wenkai , Liu Qian , Ge Hongwei , Meng Jun , Zhang Qiang , Wei Xiaopeng
Published: September 2021

Computer vision (CV) technologies are assisting the health care industry in many respects, i.e., disease diagnosis. However, as a pivotal procedure before and after surgery, the inventory work of surgical instruments has not been researched with the CV-powered technologies. To reduce the risk and hazard of surgical tools’ loss, we propose a study of systematic surgical instrument classification and introduce a novel attention-based deep neural network called SKA-ResNet which is mainly composed of: (a) A feature extractor with selective kernel attention module to automatically adjust the receptive fields of neurons and enhance the learnt expression and (b) A multi-scale regularizer with KL-divergence as the constraint to exploit the relationships between feature maps. Our method is easily trained end-to-end in only one stage with few additional calculation burdens. Moreover, to facilitate our study, we create a new surgical instrument dataset called SID19 (with 19 kinds of surgical tools consisting of 3800 images) for the first time. Experimental results show the superiority of SKA-ResNet for the classification of surgical tools on SID19 when compared with state-of-the-art models. The classification accuracy of our method reaches up to 97.703%, which is well supportive for the inventory and recognition study of surgical tools. Also, our method can achieve state-of-the-art performance on four challenging fine-grained visual classification datasets.
Genome-Wide Linkage and Association Study of Childhood Gender Nonconformity in Males
Authors: Sanders Alan R. , Beecham Gary W. , Guo Shengru , Dawood Khytam , Rieger Gerulf , Krishnappa Ritesha S. , Kolundzija Alana B. , Bailey J. Michael , Martin Eden R.
Published: September 2021

Male sexual orientation is influenced by environmental and complex genetic factors. Childhood gender nonconformity (CGN) is one of the strongest correlates of homosexuality with substantial familiality. We studied brothers in families with two or more homosexual brothers (409 concordant sibling pairs in 384 families, as well as their heterosexual brothers), who self-recalled their CGN. To map loci for CGN, we conducted a genome-wide linkage scan (GWLS) using SNP genotypes. The strongest linkage peaks, each with significant or suggestive two-point LOD scores and multipoint LOD score support, were on chromosomes 5q31 (maximum two-point LOD = 4.45), 6q12 (maximum two-point LOD = 3.64), 7q33 (maximum two-point LOD = 3.09), and 8q24 (maximum two-point LOD = 3.67), with the latter not overlapping with previously reported strongest linkage region for male sexual orientation on pericentromeric chromosome 8. Family-based association analyses were used to identify associated variants in the linkage regions, with a cluster of SNPs (minimum association p = 1.3 × 10–8) found at the 5q31 linkage peak. Genome-wide, clusters of multiple SNPs in the 10–6 to 10–8p-value range were found at chromosomes 5p13, 5q31, 7q32, 8p22, and 10q23, highlighting glutamate-related genes. This is the first reported GWLS and genome-wide association study on CGN. Further increasing genetic knowledge about CGN and its relationships to male sexual orientation should help advance our understanding of the biology of these associated traits.
Intraspecific Abundance–Occupancy–Patchiness Relations in the Intertidal Benthic Macrofauna of a Cool-Temperate North Sea Mudflat
Authors: Barnes R. S. K.
Published: September 2021

The macroecological variable of patchiness (Lloyd’s Ip index of patchiness, P) has recently been shown to be related inter- and intraspecifically to those of abundance (numbers m−2, A), and occupancy (% occurrence in samples, O) in lower latitude seagrass macrofaunas. For the first time in higher latitudes, intraspecific relationships between three spatial variables were investigated in the intertidal mudflat macrobenthos of the Scolt Head barrier island, southern North Sea (53° N, 01° E). Sampling was conducted between early July and late September 2009–2013 using 710-µm mesh for sample processing. Strong positive interspecific A-O and negative interspecific P-O and P-A relationships were present. Two of the most numerous and widespread assemblage components, however, occurred with effectively constant occupancy (Peringia ulvae, 100%, and Tubificoides benedii, 93%) across the whole 20-ha locality and therefore could not show intraspecific relationships of occupancy with other macroecological metrics. These two apart, only one other dominant species failed to show a significant positive intraspecific A-O relationship; no species showed significant P-A relations of any form; and only two showed the negative P-O ones that have been described elsewhere. The intraspecific A-O patterns appear to contrast with those of an earlier study at another North Sea locality (the Dutch Wadden Sea), although differences are more apparent than real, but the Scolt Head fauna showed fewer intraspecific P-O and P-A relations than those characterising similar circumstances in the two lower-latitude localities previously investigated. Neither developmental mode nor variation in local abundance appears to influence these patterns. A-O-P relations therefore seem widespread but may be subject to latitudinal modification.
Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2
Authors: Ebob Oyere Tanyi , Babiaka Smith B. , Ntie-Kang Fidele
Published: September 2021

For the past 2 years, the coronavirus responsible for the COVID-19 infection has become a world pandemic, ruining the lives and economies of several nations in the world. This has scaled up research on the virus and the resulting infection with the goal of developing new vaccines and therapies. Natural products are known to be a rich source of lead compounds for drug discovery, including against infectious diseases caused by microbes (viruses, bacteria and fungi). In this review article, we conducted a literature survey aimed at identifying natural products with inhibitory concentrations against the coronaviruses or their target proteins, which lie below 10 µM. This led to the identification of 42 compounds belonging to the alkaloid, flavonoid, terpenoid, phenolic, xanthone and saponin classes. The cut off concentration of 10 µM was to limit the study to the most potent chemical entities, which could be developed into therapies against the viral infection to make a contribution towards limiting the spread of the disease.
Oxygen-Containing Functional Groups Regulating the Carbon/Electrolyte Interfacial Properties Toward Enhanced K+ Storage
Authors: Peng Yufan , Chen Zhen , Zhang Rui , Zhou Wang , Gao Peng , Wu Jianfang , Liu Hui , Liu Jilei , Hu Aiping , Chen Xiaohua
Published: September 2021

Oxygen-containing functional groups were found to effectively boost the K+ storage performance of carbonaceous materials, however, the mechanism behind the performance enhancement remains unclear. Herein, we report higher rate capability and better long-term cycle performance employing oxygen-doped graphite oxide (GO) as the anode material for potassium ion batteries (PIBs), compared to the raw graphite. The in situ Raman spectroscopy elucidates the adsorption-intercalation hybrid K+ storage mechanism, assigning the capacity enhancement to be mainly correlated with reversible K+ adsorption/desorption at the newly introduced oxygen sites. It is unraveled that the C=O and COOH rather than C-O-C and OH groups contribute to the capacity enhancement. Based on in situ Fourier transform infrared (FT-IR) spectra and in situ electrochemical impedance spectroscopy (EIS), it is found that the oxygen-containing functional groups regulate the components of solid electrolyte interphase (SEI), leading to the formation of highly conductive, intact and robust SEI. Through the systematic investigations, we hereby uncover the K+ storage mechanism of GO-based PIB, and establish a clear relationship between the types/contents of oxygen functional groups and the regulated composition of SEI.
Types, characteristics and anatomic location of physical signs in elder abuse: a systematic review
Authors: van Houten Miriam E. , Vloet Lilian C. M. , Pelgrim Thomas , Reijnders Udo J. L. , Berben Sivera A. A.
Published: September 2021

Purpose

Elder abuse is a worldwide problem with serious consequences for individuals and society. The recognition of elder abuse is complex due to a lack of awareness and knowledge. In this systematic review, types, characteristics and anatomic location of physical signs in elder abuse were identified.

Methods

Databases of MEDLINE, COCHRANE, EMBASE and CINAHL were searched. The publication dates ranged from March 2005 to July 2020. In addition to the electronic searches, the reference lists and citing of included articles were hand-searched to identify additional relevant studies. The quality of descriptive and mixed-methods studies was assessed.

Results

The most commonly described physical signs in elder abuse were bruises. The characteristics of physical signs can be categorized into size, shape and distribution. Physical signs were anatomically predominantly located on the head, face/maxillofacial area (including eyes, ears and dental area), neck, upper extremities and torso (especially posterior). Physical signs related to sexual elder abuse were mostly located in the genital and perianal area and often accompanied by a significant amount of injury to non-genital parts of the body, especially the area of the head, arms and medial aspect of the thigh.

Conclusions

Most common types, characteristics and anatomic location of physical signs in elder abuse were identified. To enhance (early) detection of physical signs in elder abuse, it is necessary to invest in (more) in-depth education and to include expertise from a forensic physician or forensic nurse in multidisciplinary team consultations.
Discontinuous Galerkin Methods for a Class of Nonvariational Problems
Authors: Dedner Andreas , Pryer Tristan
Published: September 2021

We extend the finite element method introduced by Lakkis and Pryer (SIAM J. Sci. Comput. 33(2): 786–801, 2011) to approximate the solution of second-order elliptic problems in nonvariational form to incorporate the discontinuous Galerkin (DG) framework. This is done by viewing the “finite element Hessian” as an auxiliary variable in the formulation. Representing the finite element Hessian in a discontinuous setting yields a linear system of the same size and having the same sparsity pattern of the compact DG methods for variational elliptic problems. Furthermore, the system matrix is very easy to assemble; thus, this approach greatly reduces the computational complexity of the discretisation compared to the continuous approach. We conduct a stability and consistency analysis making use of the unified framework set out in Arnold et al. (SIAM J. Numer. Anal. 39(5): 1749–1779, 2001/2002). We also give an a posteriori analysis of the method in the case where the problem has a strong solution. The analysis applies to any consistent representation of the finite element Hessian, and thus is applicable to the previous works making use of continuous Galerkin approximations. Numerical evidence is presented showing that the method works well also in a more general setting.
Inter-relationship between microstructure evolution and mechanical properties in inertia friction welded 8630 low-alloy steel
Authors: Banerjee Amborish , Ntovas Michail , Da Silva Laurie , Rahimi Salaheddin , Wynne Bradley
Published: September 2021

The evolution of microstructure and mechanical properties in AISI 8630 low-alloy steel subjected to inertia friction welding (IFW) have been investigated. The effects of three critical process parameters, viz. rotational speed, friction and forge forces, during welding of tubular specimens were explored. The mechanical properties of these weld joints, including tensile and Charpy V-notch impact were studied for determining the optimum welding parameters. The weld joints exhibited higher yield strength, lower hardening capacity and ultimate tensile strength compared to base metal (BM). The maximum strength and ductility combination was achieved for the welds produced under a nominal weld speed of ~ 2900–3100 rpm, the highest friction force of ~ 680–720 kN, and the lowest axial forging load of ~ 560–600 kN. The measured hardness distribution depicted higher values for the weld zone (WZ) compared to the thermo-mechanically affected zone (TMAZ), heat-affected zone (HAZ) and BM, irrespective of the applied welding parameters. The substantial increase in the hardness of the WZ is due to the formation of microstructures that were dominated by martensite. The observed microstructural features, i.e. the fractions of martensite, bainite and ferrite, show that the temperature in the WZ and TMAZ was above Ac3, whereas that of the HAZ was below Ac1 during the IFW. The fracture surface of the tensile and impact-tested specimens exhibited the presence of dimples nucleating from the voids, thus indicating a ductile failure. EBSD maps of the WZ revealed the formation of subgrains inside the prior austenite grains, indicating the occurrence of continuous dynamic recrystallisation during the weld. Analysis of crystallographic texture indicated that the austenite microstructure (i.e. FCC) in both the WZ and TMAZ undergoes simple shear deformation during IFW.
Clinical Significance of Applause Sign in Patients with Progressive Supranuclear Palsy
Authors: Chatterjee Koustav , Choudhury Supriyo , Trivedi Santosh , Basu Purba , Kumar Hrishikesh
Published: September 2021

Applause sign (AS) is a clinical phenomenon observed in several neurological disorders including progressive supranuclear palsy (PSP). We investigated the factors associated with AS in patients with PSP. PSP patients with AS showed greater motor impairment compared to those with negative AS. Global cognition including attention and memory were affected more in patients with positive AS. We also observed that gait variability, a known marker for unstable gait is pronounced in those who presented with positive AS. Hence, the clinician might expect a more severe disease and an unstable gait in a PSP patient presenting with AS.
Is General Anesthesia for Endovascular Thrombectomy Helpful or Harmful?
Authors: Harrison E. L. , Hill Michael D.
Published: September 2021

Endovascular thrombectomy (EVT) has significantly improved outcomes for patients with acute ischemic stroke due to large vessel occlusion. However, despite advances, more than half of patients remain functionally dependent 3 months after their initial stroke. Anesthetic strategy may influence both the technical success of the procedure and overall outcomes. Conventionally, general anesthesia (GA) has been widely used for neuroendovascular procedures, particularly for the distal intracranial circulation, because the complete absence of movement has been considered imperative for procedural success and to minimize complications. In contrast, in patients with acute stroke undergoing EVT, the optimal anesthetic strategy is controversial. Nonrandomized studies suggest GA negatively affects outcomes while the more recent anesthesia-specific RCTs report improved or unchanged outcomes in patients managed with versus without GA, although these findings cannot be generalized to other EVT capable centers due to a number of limitations. Potential explanations for these contrasting results will be addressed in this review including the effect of different anesthetic strategies on cerebral and systemic hemodynamics, revascularization times, and periprocedural complications.
CTS teams: a new model for translational team training and team science intervention
Authors: McCormack Wayne T. , Levites Strekalova Yulia A.
Published: September 2021

Introduction:

Clinical/translational science (CTS) is team-based, requiring effective collaboration and communication across many disciplines involving a variety of stakeholders. We implemented a pre-doctoral team-based training model with didactic and experiential curricular interventions to support the development of CTS research skills in a cross-disciplinary team environment. We assessed the potential impact of this new training model as a team science intervention that can catalyze new cross-disciplinary collaborations across the institution.

Methods:

Between 2016 and 2020, 32 pre-doctoral students and 26 co-mentors participated in the assessment of the CTS Team program over a two-year period of TL1 training grant support. Data collection and analyses followed a program logic model and used a variety of metrics for clinical and translational scientist career success.

Results:

CTS training in the context of CTS Teams supported improved self-efficacy for clinical research skills and resulted in a significant increase in the frequency of participation in cross-disciplinary collaborative activities by both trainees and mentors. Most CTS Team co-mentor pairs had not previously collaborated. Two-thirds of the co-mentors plan to continue collaborating, and most (85%) currently use or plan to use collaboration tools, for example, written collaboration plans, authorship agreements.

Conclusions:

The CTS Team training model provides a unique clinical and translational science team training experience that embeds authentic cross-disciplinary research collaboration into PhD research projects. It establishes trainee cohorts that are diverse in terms of scientific disciplines and translational research phases, and creates a new cross-disciplinary community of practice across faculty members and research groups in multiple colleges.
SOME STABLE NON-ELEMENTARY CLASSES OF MODULES
Authors: MAZARI-ARMIDA MARCOS
Published: September 2021

Fisher [10] and Baur [6] showed independently in the seventies that if T is a complete first-order theory extending the theory of modules, then the class of models of T with pure embeddings is stable. In [25, 2.12], it is asked if the same is true for any abstract elementary class
$(K, \leq _p)$
such that K is a class of modules and
$\leq _p$
is the pure submodule relation. In this paper we give some instances where this is true:

Theorem.

Assume R is an associative ring with unity. Let
$(K, \leq _p)$
be an AEC such that
$K \subseteq R\text {-Mod}$

and K is closed under finite direct sums, then:

•

If K is closed under pure-injective envelopes, then
$\mathbf {K}$
is
$\lambda $
-stable for every
$\lambda \geq \operatorname {LS}(\mathbf {K})$
such that
$\lambda ^{|R| + \aleph _0}= \lambda $
.

•

If K is closed under pure submodules and pure epimorphic images, then
$\mathbf {K}$
is
$\lambda $
-stable for every
$\lambda $
such that
$\lambda ^{|R| + \aleph _0}= \lambda $
.

•

Assume R is Von Neumann regular. If
$\mathbf {K}$
is closed under submodules and has arbitrarily large models, then
$\mathbf {K}$
is
$\lambda $
-stable for every
$\lambda $
such that
$\lambda ^{|R| + \aleph _0}= \lambda $
.

As an application of these results we give new characterizations of noetherian rings, pure-semisimple rings, Dedekind domains, and fields via superstability. Moreover, we show how these results can be used to show a link between being good in the stability hierarchy and being good in the axiomatizability hierarchy.

Another application is the existence of universal models with respect to pure embeddings in several classes of modules. Among them, the class of flat modules and the class of
$\mathfrak {s}$
-torsion modules.
CONSECUTIVE SQUARE-FREE NUMBERS IN PIATETSKI-SHAPIRO SEQUENCES
Authors: TANGSUPPHATHAWAT PINTHIRA , SRICHAN TEERAPAT , LAOHAKOSOL VICHIAN
Published: September 2021

Using a method due to Rieger [‘Remark on a paper of Stux concerning squarefree numbers in non-linear sequences’, Pacific J. Math.78(1) (1978), 241–242], we prove that the Piatetski-Shapiro sequence defined by
$\{\lfloor n^c \rfloor : n\in \mathbb {N}\}$
contains infinitely many consecutive square-free integers whenever
$1<c<3/2$
.
Metabolomic profiling of the Dietary Approaches to Stop Hypertension diet provides novel insights for the nutritional epidemiology of type 2 diabetes mellitus
Authors: Yashpal Shahen , Liese Angela D. , Boucher Beatrice A. , Wagenknecht Lynne E. , Haffner Steven M. , Johnston Luke W. , Bazinet Richard P. , Rewers Marian , Rotter Jerome I. , Watkins Steve M. , Hanley Anthony J.
Published: September 2021

Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet is inversely associated with type 2 diabetes mellitus (T2DM) risk. Metabolic changes due to DASH adherence and their potential relationship with incident T2DM have not been described. The objective is to determine metabolite clusters associated with adherence to a DASH-like diet in the Insulin Resistance Atherosclerosis Study cohort and explore if the clusters predicted 5-year incidence of T2DM. The current study included 570 non-diabetic multi-ethnic participants aged 40–69 years. Adherence to a DASH-like diet was determined a priori through an eighty-point scale for absolute intakes of the eight DASH food groups. Quantitative measurements of eighty-seven metabolites (acylcarnitines, amino acids, bile acids, sterols and fatty acids) were obtained at baseline. Metabolite clusters related to DASH adherence were determined through partial least squares (PLS) analysis using R. Multivariable-adjusted logistic regression was used to explore the associations between metabolite clusters and incident T2DM. A group of acylcarnitines and fatty acids loaded strongly on the two components retained under PLS. Among strongly loading metabolites, a select group of acylcarnitines had over 50 % of their individual variance explained by the PLS model. Component 2 was inversely associated with incident T2DM (OR: 0·89; (95 % CI 0·80, 0·99), P-value = 0·043) after adjustment for demographic and metabolic covariates. Component 1 was not associated with T2DM risk (OR: 1·02; (95 % CI 0·88, 1·19), P-value = 0·74). Adherence to a DASH-type diet may contribute to reduced T2DM risk in part through modulations in acylcarnitine and fatty acid physiology.
A maternal low-protein diet during gestation induces hepatic autophagy-related gene expression in a sex-specific manner in Sprague-Dawley rats
Authors: Cai Mingzhu , Zhang Jie , Chen Hong , Pan Yuan-Xiang
Published: September 2021

This study investigates the mechanism by which maternal protein restriction induces hepatic autophagy-related gene expression in the offspring of rats. Pregnant Sprague-Dawley rats were fed either a control diet (C, 18 % energy from protein) or a low-protein diet (LP, 8·5 % energy from protein) during gestation, followed by the control diet during lactation and post-weaning. Liver tissue was collected from the offspring at postnatal day 38 and divided into four groups according to sex and maternal diet (F-C, F-LP, M-C and M-LP) for further analysis. Autophagy-related mRNA and protein levels were determined by real-time PCR and Western blotting, respectively. In addition, chromatin immunoprecipitation (ChIP) was performed to investigate the interactions between transcription factors and autophagy-related genes. Protein levels of p- eukaryotic translation initiation factor 2a and activating transcription factor 4 (ATF4) were increased only in the female offspring born to dams fed the LP diet. Correlatively, the mRNA expression of hepatic autophagy-related genes including Map1lc3b, P62/Sqstm1, Becn1, Atg3, Atg7 and Atg10 was significantly greater in the F-LP group than in the F-C group. Furthermore, ChIP results showed greater ATF4 and C/EBP homology protein (CHOP) binding at the regions of a set of autophagy-related genes in the F-LP group than in the F-C group. Our data demonstrated that a maternal LP diet transcriptionally programmed hepatic autophagy-related gene expression only in female rat offspring. This transcriptional programme involved the activation of the eIF2α/ATF4 pathway and intricate regulation by transcription factors ATF4 and CHOP.
Dietary consumption of tea and the risk of prostate cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Authors: Thomas Robert , Greef Basma , McConnachie Alex , Stanley Bethany , Williams Madeleine
Published: September 2021

Tea contains polyphenols such as flavonoids, anthocyanidins, flavanols and phenolic acids which in laboratory studies have reported to promote antioxidant enzyme formation, reduces excess inflammation, slow cancer cell proliferation and promote apoptosis. Evidence from epidemiological studies on the effect of tea consumption on prostate cancer (CaP) incidence has been conflicting. We analysed data from 25 097 men within the intervention arm of the 155 000 participant Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Histologically confirmed cases of prostate cancer were reported in 3088 men (12·3 %) during the median 11·5 year follow-up. Tea consumption was assessed with a FFQ. Baseline characteristics were compared between groups using χ2 and Kruskal–Wallis tests. Cox regression models were used to assess associations between tea intake and CaP incidence. There was no statistical difference between the risk of CaP between men who never drank tea to those who drank tea at any quantity. Amongst tea drinkers, those in the highest third of consumption group had a small but significantly lower risk compared with those in the lowest third (11·2 % v. 13·2 % hazard ratio 1·16; (95 % CI 1·05, 1·29), P = 0·004). This pattern persisted with adjustments for demographics and lifestyle. In conclusion, among tea drinkers, there was a small positive association between drinking tea and a reduced risk of prostate cancer. It does not support starting to drink tea, if men previously did not, to reduce the risk. Further research is needed to establish whether tea is justified for future prospective nutritional intervention studies investigating CaP prevention.
Role of whey protein in vascular function: a systematic review and meta-analysis of human intervention studies
Authors: Hajizadeh-Sharafabad Fatemeh , Sharifi Zahabi Elham , Tarighat-Esfanjani Ali
Published: September 2021

Whey protein (WP) has been heavily appreciated as a rich source of bioactive peptides, with potential benefits for cardiovascular health. This study constitutes a systematic review and meta-analysis summarising the effects of WP consumption on vascular reactivity, arterial stiffness and circulatory biomarkers of vascular function. We searched electronic databases, including PubMed, SCOPUS and Web of science for relevant articles from inception to July 2020. Original clinical trials published in English-language journals that investigated the effects of WP on vascular function were eligible. A total of 720 records were identified in the initial search; from these, sixteen were included in our systematic review and thirteen in meta-analysis. The pooled analysis of six studies showed a significant increase in flow-mediated dilation (FMD) after WP consumption (weighted mean differences (WMD): 1·09 %, 95 % CI: 0·17, 2·01, P= 0·01). Meta-analysis of available data did not show any significant reduction in arterial stiffness measures including augmentation index (effect sizes: 7, WMD: −0·29 %, 95 % CI: −1·58, 0·98, P= 0·64) and pulse wave velocity (effect sizes: 4, WMD: −0·72 m/s, 95 % CI: −1·47, 0·03, P= 0·06). Moreover, the pooled analysis of six effect sizes showed no significant effects on plasma levels of nitric oxide following WP supplementation (WMD: 0·42 μmol/l, 95 % CI: −0·52, 1·36, P= 0·38). The overall results provided evidence supporting a protective effect of WP on endothelial function measured by FMD, but not for arterial stiffness measures and circulatory biomarker of vascular function. Further research is required to substantiate the benefits of WP on vascular function.
Israeli Pre-Transitional Justice and the Nakba Law
Authors: Kapshuk Yoav , Strömbom Lisa
Published: September 2021

Pre-transitional justice activities that expose past injustices during entrenched conflicts can incite strong reactions among actors who feel threatened by or dislike such activities, and who thus attempt to silence controversial truths. This article illuminates how attempts to silence controversial truths, in parallel with shutting down debate, can also have the unintended outcome of enlarging public discourse on previously marginalised issues. Thus, paradoxically, efforts to curb freedom of expression sometimes result instead in an expanded public capacity to debate previously silenced truths about the conflict. We conduct a case study of reactions to pre-transitional justice in Israeli society focusing on the so-called Nakba Law, enacted in 2011. Through interviews with members of the non-governmental organisation Zochrot, politicians, teachers and media persons, we first show the relationship between pre-transitional justice and enacting the Nakba Law. We then demonstrate that while the Nakba Law indeed aimed to hamper freedom of expression, it also enabled increased public knowledge about the meaning of Nakba. Our theoretical proposition regarding this paradox, in this case activated by instigating new memory laws, is highly relevant to other conflicts-in-resolution that experience pre-transitional justice processes.
What factors are associated with forms of mistreatment during facility-based childbirth? A survey of referral health facilities in south-east Nigeria
Authors: Okedo-Alex Ijeoma Nkem , Akamike Ifeyinwa Chizoba , Igwilo Ugonna , Onwasigwe Chika Nwakanma
Published: September 2021

Mistreatment during childbirth in health facilities contributes significantly to suboptimal levels of skilled birth attendance. This study determined the factors associated with mistreatment during facility-based childbirth in two referral facilities in south-east Nigeria. A survey of 620 women whose childbirth occurred in two high-patronage referral hospitals of Ebonyi, Nigeria, was conducted in July–September 2018 using interviewer-administered questionnaires. Data analysis was performed using SPSS version 20. Logistic regression was used to identify predictors. The mean age of the respondents was 29.86 ± 4.4 years. Most had post-secondary education (71.0%), and had attended at least four antenatal visits (83.4%). The prevalence of any mistreatment during childbirth was 56%. Rural residence (adjusted odds ratio [AOR]: 0.53; CI: 0.35, 0.78, p = 0.002) and childbirth facilitated by a doctor (AOR: 1.7; CI: 1.14, 2.39, p = 0.007) were predictors of reporting at least one form of mistreatment during childbirth. Childbirth facilitated by a doctor (AOR: 1.66; CI: 1.05, 2.63, p = 0.031) and unemployment (AOR: 1.84; CI: 1.01, 3.07, p = 0.011) increased the odds of non-consented and non-dignified care, respectively. Rural residence (AOR: 0.57; CI: 0.37, 0.88, p = 0.011) and childbirth facilitated by a doctor (AOR: 0.65; CI: 0.45, 0.94, p = 0.020) were protective against abandonment/neglect. Vaginal birth (AOR: 0.33; CI: 0.16, 0.69, p = 0.003) reduced the odds of detention in the health facility following childbirth. Almost three-fifths of the women whose childbirths occurred in the surveyed facilities experienced at least one form of mistreatment during childbirth. Place of residence, health professional type, mode of childbirth, employment status and frequency of antenatal attendance were predictors of mistreatment during childbirth. Rights-based sensitization for women, especially in the rural areas, female empowerment, provider capacity-building on respectful client care and provision of subsidized maternal health services are recommended.
Evaluation of Annona muricata (Graviola) leaves activity against experimental trichinellosis: in vitro and in vivo studies
Authors: El-Wakil E.S. , Abdelmaksoud H.F. , AbouShousha T.S. , Ghallab M.M.I.
Published: September 2021

Our work aimed to evaluate the possible effect of Annona muricata (Graviola) leaf extract on Trichinella spiralis in in vitro and in vivo studies. Trichinella spiralis worms were isolated from infected mice and transferred to three culture media – group I (with no drugs), group II (contained Graviola) and group III (contained albendazole) – then they were examined using the electron microscope. In the in vivo study, mice were divided into five groups: GI (infected untreated), GII (prophylactically treated with Graviola for seven days before infection), GIII (infected and treated with Graviola), GIV (infected and treated with albendazole) and GV (infected and treated with a combination of Graviola plus albendazole in half doses). Drug effects were assessed by adults and larvae load beside the histopathological small intestinal and muscular changes. A significant reduction of adult and larval counts occurred in treated groups in comparison to the control group. Histopathologically, marked improvement in the small intestinal and muscular changes was observed in treated groups. Also, massive destruction of the cultured adults’ cuticle was detected in both drugs. This study revealed that Graviola leaves have potential activity against trichinellosis, especially in combination with albendazole, and could serve as an adjuvant to anti-trichinellosis drug therapy.
Common Morality Principles in Biomedical Ethics: Responses to Critics
Authors: Childress James F. , Beauchamp Tom L.
Published: September 2021

After briefly sketching common-morality principlism, as presented in Principles of Biomedical Ethics, this paper responds to two recent sets of challenges to this framework. The first challenge claims that medical ethics is autonomous and unique and thus not a form of, or justified or guided by, a common morality or by any external morality or moral theory. The second challenge denies that there is a common morality and insists that futile efforts to develop common-morality approaches to bioethics limit diversity and prevent needed moral change. This paper argues that these two critiques fundamentally fail because they significantly misunderstand their target and because their proposed alternatives have major deficiencies and encounter insurmountable problems.
Un(COIL)ing the Pandemic: Active and Affective Learning in Times of COVID-19
Authors: Cotoman Violeta , Davies Annabel , Kawagoe Nanako , Niihashi Hana , Rahman Aisha , Tomita Yuki , Watanabe Atsuko , Rösch Felix
Published: September 2021

The COVID-19 pandemic has had a global effect on higher education. Overnight, entire degree programs had to be moved online. Whereas this meant that teaching and learning in political science and international relations also went into “emergency e-learning” mode, as a recent teacher spotlight in PS: Political Science & Politics termed it, moving online also offered opportunities. One opportunity is collaborative online international learning (COIL) that enables students from universities in different countries to work on a common project. This article argues that working together collaboratively online not only mitigates the pandemic’s physical restrictions and sustains a global space of learning; it also provides for a particular active and affective learning in an intercultural virtual environment that substantiates classroom experiences even in post-pandemic higher education. To support this argument, this article reflects on the experiences of a British–Japanese COIL project that investigated political responses to COVID-19.
Pastoral Supervision for Safe Churches
Authors: Broughton Geoff
Published: September 2021

This essay will examine the contribution of pastoral (professional) supervision in enabling and ensuring a safe church. Pastoral supervision is the brave, safe space where clergy (and ministry workers) reflect on their ministry practice in a regular, planned supervision session. The present article emerges from a decade of training pastoral supervisors and consultation across the national Anglican Church during 2019 based on recommendations made by the Royal Commission into Institutional Responses to Child Sexual Abuse. It concludes that the properly Christian way for pastoral supervision to change the culture of the Church is christological: a rigorous grounding of its theory and practice in the story of Jesus Christ.
Oceanic and Atmospheric Correlations to Cetacean Mass Stranding Events in Cape Cod, Massachusetts, USA
Authors: Zellar R. , Pulkkinen A. , Moore K. , Rousseaux C. S. , Reeb D.
Published: September 2021

Groups of pelagic dolphins and whales (order Cetacea) regularly strand on beaches throughout the world. These strandings are referred to as mass stranding events (MSEs). MSEs have been observed for centuries, however the underlying causes remain unclear. In Cape Cod, Massachusetts, USA, MSEs usually involve only a few species of cetaceans. We investigated possible connections between MSEs in Cape Cod and regional wind and ocean currents. The seasonal MSE distribution is strongly correlated to both wind and ocean current strengths, and correlation is maximized when MSEs are compared to environmental data one month in the past. Furthermore, a superposed epoch analysis (a Chree analysis) indicates significant shifts in ocean current strength for months surrounding MSEs. These results may indicate that atmospheric and oceanic effects are possible underlying factors influencing MSEs. These factors could generate environments conducive for prey assemblages that attract cetaceans, or perhaps by driving seasonal production of prey species.
Isotropic Source Components of Events in the 2019 Ridgecrest, California, Earthquake Sequence
Authors: Cheng Yifang , Wang Xin , Zhan Zhongwen , Ben‐Zion Yehuda
Published: September 2021

We investigate the non‐double‐couple components of 224 M ≥ 3.0 earthquakes in the 2019 Mw7.1 Ridgecrest sequence, which occurred on a complex fault system in the Eastern California Shear Zone. Full moment tensors are derived using waveform data from near‐fault and regional stations with a generalized cut‐and‐paste inversion and 3‐D velocity and attenuation models. The results show limited Compensated Linear Vector Dipole components, but considerable explosive isotropic components (5%–15% of the total moments) for approximately 50 earthquakes. Most of these events occur between the Mw6.4 foreshock and 1 day after the Mw7.1 mainshock and are mainly distributed around the rupture ends and fault intersections. The percentage of isotropic components is reduced considerably when data recorded by near‐fault stations are not included in the inversions, highlighting the importance of near‐fault data. The results suggest that high‐frequency damage‐related radiation and other local dilatational processes are responsible for the observed isotropic source terms.
Turbulence Characteristics of Thunderstorms Before the First Flash in Comparison to Non‐Thunderstorms
Authors: Zhao Chuanhong , Zheng Dong , Zhang Yijun , Liu Xiantong , Zhang Yang , Yao Wen , Zhang Wenjuan
Published: September 2021

This study evaluates how clouds evolve into thunderstorms in terms of the turbulence characteristics producing the first flash. Observations of 57 (39) isolated thunderstorm (non‐thunderstorm) cells during 2016/2017 in Southern China are provided by an S‐band polarimetric radar and three independent lightning location systems. The vertical turbulence characteristics of clouds associated with thunderstorms are obviously different from non‐thunderstorms. For thunderstorms, the maximum of the eddy dissipation rate (mean value in each height layer) in the entire height is 0.19 m2 s−3, which occurs at the first flash stage, and the achievable height of turbulence exceeds the −30°C layer. For non‐thunderstorms, however, the maximum is 0.12 m2 s−3, and the achievable turbulence height hardly exceeds the −10°C layer. Additionally, the turbulence intensities of the locations where the initial discharge pulse events of the first flashes occur are weak. These turbulence characteristics are useful for lightning nowcasting.
A Regime‐Based Investigation Into the Errors of CMIP6 Simulated Cloud Radiative Effects Using Satellite Observations
Authors: Miao Hao , Wang Xiaocong , Liu Yimin , Wu Guoxiong
Published: September 2021

Using a variety of CloudSat/CALIPSO products, this study synergistically examines the performance of clouds and their radiative effects (CRE) for models participating in CMIP6. Results show virtually all models overestimate the net cooling effect of clouds, which is caused by the overestimation of shortwave CRE and the underestimation of longwave CRE. By dividing clouds into regimes jointly sorted by cloud water path and cloud cover, we found models commonly underestimate the relative frequency of occurrence (RFO) for clouds that are geometrically thick, and the bias of RFO is dominant over that of within‐regime CRE in an error decomposition of total CRE. This results in underestimations of CRE in geometrically thick clouds, which are partially offset by overestimations in the remaining cloud regimes, leading to the globally averaged CRE being less biased. The consideration of regime‐based CRE gives important information that could be used for correction of cloud parameterization in models.
Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging
Authors: Zhou Jing , Fan Xiaoxiao , Wu Di , Liu Jie , Zhang Yuhuang , Ye Zikang , Xue Dingwei , He Mubin , Zhu Liang , Feng Zhe , Kuzmin Andrey N. , Liu Wen , Prasad Paras N. , Qian Jun
Published: September 2021

Bright anti-Stokes fluorescence (ASF) in the first near-infrared spectral region (NIR-I, 800 nm–900 nm) under the excitation of a 915 nm continuous wave (CW) laser, is observed in Indocyanine Green (ICG), a dye approved by the Food and Drug Administration for clinical use. The dependence of fluorescence intensity on excitation light power and temperature, together with fluorescence lifetime measurement, establish this ASF to be originated from absorption from a thermally excited vibrational level (hot-band absorption), as shown in our experiments, which is stronger than the upconversion fluorescence from widely-used rare-earth ion doped nanoparticles. To test the utility of this ASF NIR-I probe for advanced bioimaging, we successively apply it for biothermal sensing, cerebral blood vessel tomography and blood stream velocimetry. Moreover, in combination with L1057 nanoparticles, which absorb the ASF of ICG and emit beyond 1100 nm, these two probes generate multi-mode images in two fluorescent channels under the excitation of a single 915 nm CW laser. One channel is used to monitor two overlapping organs, urinary system & blood vessel of a live mouse, while the other shows urinary system only. Using in intraoperative real-time monitoring, such multi-mode imaging method can be beneficial for visual guiding in anatomy of the urinary system to avoid any accidental injury to the surrounding blood vessels during surgery.