bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulation and Evaluation as Sustain Released Nanoparticles for Zolmitriptan Hydrochloride for the enhanced Bioavailability and Better Therapeutic Action by using Chitosan as a Permeation Enhancer
Authors: Ahmad Wajid , Quazi Jaza
Published: July 2023

Chitosan was hydrophobically modified as N-Butyryl chitosan (NBC), N-Lauroyl chitosan (NLC) were synthesized and characterized by FTIR, NMR, XRD, modified chitosan were having about 14 % degree of substitution and varying solubility. Further evaluation of synthesized N-acyl chitosan to loaded Zolmitriptan HCl as nanoparticle by ionotropic method with cross linking by TPP. Average particle size, drug loading, entrapment efficiency and in-vitro mucoadhesion of Zolmitriptan HCl loaded nanoparticle was 150.7±3.3nm, 24.80±1.1% and 54.96±3.8% respectively, with positive zeta potential which were directly correlated with increases bulkiness of the acyl substitution in the modified chitosan except zeta potential was found inversely correlated. TEM and SEM imaging relieved spherical structure of nanoparticle. In vitro release of Zolmitriptan HCl in 1.2 pH HCl buffer and pH 7.4 phosphate buffer solutions showed biphasic release pattern best fitted with Korsmeyer’s-Peppas kinetics with fickian transport mechanism. Acylated chitosan showed sustained release reducing with increasing length of acyl group. Result of the present study showed that hydrophobically modified acylated chitosan can be useful for achieving sustained release controlled by acylation modification.
Enhancing Bioequivalence Predictions with PAMPA Dissolution Using Formulations of Telmisartan
Authors: Chou Joe , Lai Roger , Chou Jason , Fu Shelly , Tung Hsin-Ai
Published: July 2023

Traditionally, the pilot bioequivalence study is a generalpractice for generic drug development. However, due to its difficulty in differentiating the variation between subject and drug formulation for bioequivalence results. A new instrument called PAMPA Dissolution is proposed in this study to improve the correlation between in vitro and in vivo absorption forbioequivalence study. PAMPA Dissolution allows for the simultaneous measurement of drug dissolution (Cb) and permeation (Pe), two key parameters in oral drug absorption according to the validated equation F (drug absorbed) = Cb*Pe*Area. The use of Parallel Artificial Membrane Permeability Assay (PAMPA) eliminates the concern of subject variation. Biorelevant media further allows this device to simulate in vivo conditions closely. Brand and generic formulations of 40 mg telmisartan tablets were used in various studies to demonstrate the potential of PAMPA Dissolution in generic drug development. Bioequivalence predictions between brand and generic telmisartan from PAMPA Dissolution produced avalue（test/reference）for Cmax of 86.3% and a value for AUC of 91.4%, indicating that PAMPA Dissolution predictions conform with bioequivalence requirements. Other parameters such as stirring at different speeds and phospholipids concentrations for PAMPA are also included for optimal performance of the system. Based on these data, the PAMPA Dissolution system is reproducible, precise, and can therefore be applied in predicting bioequivalence study.
A Review on Introduction to Quality Assurance
Authors: Kantilal Patil Divyashree , Rajendra Patil Divyani , A. Pati Sunila
Published: July 2023

Quality assurance (QA) is the management technique used to provide adequate confidence that a product, service, or result will satisfy requirements for quality and be fit for use. Each monitoring program or assessment must strive to generate data that is precise, dependable, and sufficient for the specified purpose. Data quality objectives are qualitative and quantitative standards that are used to create a system that will keep the level of uncertainty within permitted boundaries and at an acceptable level. Quality assurance will boost public and funding body confidence. Unconfirmed observations should not be used until they can be verified. Robust pharmaceutical quality assurance system ensures that products are effective and safe. Following good manufacturing practices (GMP) and enacting comprehensive inspection policies help drug manufacturers produce the highest quality products and avoid reputation-damaging incidents. Product Quality Review (PQR) is a mechanism to ensure that data captured by the Pharmaceutical Quality System (PQS) is reviewed for trends. This tool can support a continuous improvement environment. PQRs are designed for the purpose of identifying and implementing recommendations for required improvements. Quality control and quality assurance jobs are all about ensuring the medication has been manufactured correctly and is safe to use, as well as having its desired effect. Without these two functions of quality management, a pharmaceutical organisation would struggle to achieve consistency in its output. Quality assurance (QA) is any systematic process of determining whether a product or service meets specified requirements. QA establishes and maintains set requirements for developing or manufacturing reliable products.
РАСЧЕТ ПАРАМЕТРОВ ЛИНЕЙНОЙ АСИНХРОННОЙ МАШИНЫ СО ВТОРИЧНЫМ ЭЛЕМЕНТОМ, ПОКРЫТЫМ СЛОЕМ МЕДИ
Authors: Маилян А.Л. , Сагателян М.А. , Хангельдян А.Г.
Published: July 2023

Разработан способ улучшения параметров линейных асинхронных машин с массив¬ным вторичным элементом, которые отличаются конструкцией безобмоточ¬ного вторичного элемента, величиной и формой основных параметров и характерис¬тик. Линейные асинхронные двигатели нашли широкое применение в исполнительных механизмах промышленности и производства, которые нуждаются в линейном перемещении с необходимой величиной и законом изменения тягового усилия. Самые крупные проекты с использованием линейных асинхронных двигателей связаны с созда¬нием высокоскоростного наземного транспорта. Исследованы линейные асин¬хрон¬ные машины со вторичным массивным элементом, покрытым слоем меди. Пред¬ложен метод газодина¬ми¬¬¬чес-кого напыления меди на ферромагнитный материал, который более технологичен и экологичен в отношении материалов, изготовленных тра¬¬ди¬¬ционными методами, и позволяет получать детали с нужными механическими, элек¬три¬¬¬ческими и магнитными свойствами. Рассмотрены различные толщины мед¬ного покрытия. Показано, что с изменением толщины медного слоя возникает возможность изме¬-нения маг¬нитных и электрических параметров в заданных пределах. Приведена последо¬ва¬тель¬ность расчета параметров линейной асинхронной машины со вторич¬ным эле¬мен¬том, покрытым слоем меди. Произведен расчет параметров линейной асин¬хрон¬ной маши¬ны с массивным вторичным элементом с медным покрытием разной толщины. Постро¬е¬ны зависимости эквивалентного активного сопротивления вторич¬ного элемента и кри¬ти¬ческого скольжения от толщины медного покрытия. На основе представленного метода произведен расчет механических характеристик линей¬ного асинхронного дви¬гателя с массивным вторичным элементом, покрытым медным слоем разной толщины. По полученным расчетным данным построены меха¬ни¬ческие характеристики линей¬ного асинхронного двигателя с массивным вторичным элементом разного исполнения.
The legitimacy of power: determining factors in post-war Ukraine
Authors:   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kononenko Natalia
Published: July 2023

In the center of the article is an analysis of the transformation of Ukrainians and our civil society during the first year of the full-scale Russian-Ukrainian war, conducted by the author with the aim of determining the possible limits of the format of the post-war normalization of the defects of Ukrainian democracy. Among the defects is the functioning of power, which gains the influence due to the electoral procedures of electoral democracies, but does not receive final legitimation due to the lack or even absence of public trust. The political product of the crisis of legitimacy of power in transit Ukrainian democracy is a weak state with dual institutions and an asthenic state of Ukrainian society with a dual national identity. The full-scale Russian-Ukrainian war created unique grounds (for the first time in 30 years after the renewal of Ukrainian independence) for the localization of the influence of the crisis of the legitimacy of power on the Ukrainian political system. The value evolution of Ukrainians, the active formation of national and civil identities, the unification of society, the formation of high level of trust of Ukrainians to the authorities, and the acquisition of new experiences by civil society – all these factors give hope for the formation and implementation of conventional instruments for overcoming crises and, accordingly, for the active promotion of Ukrainian democracy towards consolidation. The author notes that the qualitative construction of anti-crisis policies for the nearest future requires avoiding voluntarism when assessing the modernization potential of society, which determines the reforming potential of civil society. An objective look at modern Ukrainians forces us to recognize the fact that we have preserved a certain value dichotomy, certainly in much smaller sizes than on the eve of February 24, 2022. The axiological specificity of modern Ukrainians will also determine the post-war opportunities of civil society. Therefore, civil society will be active in the areas of supporting reforms, resuming all democratic procedures and processes after the end of hostilities, and actively formation of a new culture of discourse within the country. Advocacy of liberal democracy requires the participation of an exogenous actor.
EFFECTIVENESS OF MICROBIAL ENDOPHYTES ON CROP IMPROVEMENT AND CURE THE DISEASES
Authors: VAGHASIYA HARSHA Y. , LEVA R.L. , PATEL ARTEEBAHEN
Published: July 2023

Microorganisms colonize the plant tissue and beneficial to the plant is known as endophytes. Fungal and bacterial endophytes are commonly found in most of the plants. The role of endophytic microorganisms in plants can be divided into two categories based on types of activity: plant growth promotion and disease control in plants. The search for new compounds effective against human diseases is still a priority in medicine. The evaluation of microorganisms isolated from non-conventional locations offers an alternative to look for new compounds with pharmacological activity. Endophytes are a natural source with remarkable chemical and biological properties. Endophytes are considered promising sources of new bioactive natural products. Present review will concentrate on the importance of endophytes for crop improvement and clinical applications of bioactive compounds isolated from endophytes.
Pharmacognostic, Forensic and Pharmaceutical, Organizational and Legal, Clinical and Pharmacological Multidisciplinary Study with an Assessment of Peculiarities of Circulation (Use) of Smoking Mixtures of Spices and Entheogens of Amanita Muscaria Mushroom
Authors: Shapovalova Viktoriia , Osyntseva Alina , Shapovalov Valerii , Nehretskii Serhii
Published: July 2023

A multidisciplinary pharmacognostic, forensic and pharmaceutical, organizational and legal, clinical and pharmacological, forensic and medical, toxicological, chemical evaluation of the irrational use of spices in smoking mixtures from the group of entheogens was carried out. An expert assessment of spices – plants and mushrooms containing psychoactive substances with hallucinogenic effects. Forensic and pharmaceutical practice was analyzed. A conclusion was made about the irrational use of smoking mixtures from the group of entheogens of the amanita muscaria mushroom, which contain psychoactive substances – psilocybin or psilocin. A forensic medical and toxicological study of amanita poisoning was conducted. Informed about pharmaceutical safety measures in case of amanita poisoning. A pharmacognostic study of "Amanita muscaria" – a fly agaric mushroom was conducted. According to the results of the normative study of the features of the circulation of fly agaric entheogens, normative initiatives are proposed.
THE POSSIBILITIES OF ANALYZING THE INVERSION LAYER ACCORDING TO REANALYSIS DATA
Authors:   RSE «Kazhydromet», Makhambetova M.M. , Abayev N.N.
Published: July 2023

The study of thermal inversion layers in the atmosphere plays an important role in understanding various atmospheric processes and solving environmental and meteorological problems. This work is devoted to evaluating the potential of thermal inversion layer analysis using ERA5 reanalysis data in the nearground layer as an alternative to the limited availability of aerological stations.The characteristics of inversions calculated using ERA5 reanalysis data and radiosonde data from the Karaganda Aerological Station for the period from 2012 to 2021 were compared. General inversions occur most often in January (15...18 times), while in spring and autumn, the average monthly number of cases is 4...10. In the summertime, surface inversions occur most frequently, with a mean monthly value of up to 25 times. The intensity of different surface inversions varies between -1 °C ... -9 °С. The results of the study showed a close similarity between the ERA5 reanalysis data and the radiosonde data. This indicates the suitability of the reanalysis data for studying thermal inversions. This study contributes to the development of knowledge in atmospheric pollution, weather forecasting, aviation meteorology, and the development of climate models by using reanalysis data to study inversion phenomena.
Here to Stay: Building a Tenant Association Against Displacement
Authors:   Flower Drive Tenants Association, Vilenica Ana , Albright Katrina
Published: July 2023

The Flower Drive Tenants Association (La Asociación de inquilinos de Flower Drive) is an entire block of tenants organising against displacement in South Central Los Angeles. Members of the Los Angeles Tenants Union since March 2021, Flower Drive tenants have fought to stay put in the face of a multi-billion dollar development plan to replace hundreds of rent controlled apartments with luxury housing. In the process they have transformed their block of working class Black and Latino tenants into what one comrade described as a “semillero” – a seedbed of tenant organising across South Central Los Angeles. The señoras who lead the Flower Drive TA have also turned their weekly meeting into a co-learning space for the wider community. As many as 60 tenants from across South Central LA gather each week in a parking lot behind the Flower Drive buildings to discuss their rights, share their experiences, and plan direct actions. Tenants support each other through protesting landlords, reversing lockouts, and even confronting domestic abusers. Tenants have also begun to discuss their deeper political conditions, drawing connections to popular land struggles across the world.
Emerging technologies for carbon reduction in building industry: Evidence
from patent inventions
Authors: Li Lingyue
Published: July 2023

According to the "Global Building Construction Industry Report" released
by the United Nations Environment Programme, the carbon emissions generated
by building operations alone have reached about 10 gigatonnes in 2021. With
its rapid and large-scale urbanization, China is one of the main
contributors to the global carbon emission. Decarbonization thus became the
central task for China's building sector. Emerging technologies, especially
digital technologies, provide the potential for building decarbonization,
which is possibly realized through the full life cycle of buildings. Yet,
understanding towards a localized innovation of these technologies and how
they engage carbon reduction remains far from clear. Moreover, due to the
large scale and massive nature of buildings, threshold of business
applications of these emerging technologies is high thus discussed
insufficiently. Draws on literature and expert review, this research
discloses the linkage of 14 specific emerging technologies and building
decarbonization in a full life-cycle (the planning, construction,
use/operation and demolition phases) of buildings. Yangtze River Delta, one
of the fastest urbanizing and largest market for building sector in China,
is selected for observation. With an OT-matrix and over thousand sorted
patent inventions, it identifies that contribution of the emerging
technologies to building decarbonization is most secondary. Quite a few
general-purpose technologies (e.g., blockchain, IoT), which possibly disrupt
the industry fundamentally, are almost vacant. State owned enterprises are
the main actors in the technology innovation, followed by university and
public research institutions. There is a mixed location of downtown,
periphery and outskirts characterizing the spatial pattern of these
technologies. The findings help to recommend policy makers, firm managers,
professionals and researchers in accessing and developing disruptive
technologies for low carbon building industry, and promote business
application in this field.
The Effects of Happy and Sad Dynamic Digital Art on Relieving Stress
Authors: Wang Qiurui , Hu Jun , Liu Zhenyu , He Caihong
Published: July 2023

Experiencing psychological stress due to the demands of modern life is
common, but engaging with innovative digital art has the potential to
alleviate this stress and provide a source of relaxation. Moreover, the
interactive and dynamic nature of digital art offers diverse and distinctive
experiences. The aim of this article is to determine if the process of
transferring dynamic digital art images while playing happy and sad music
can have an impact on an individual's stress level. For the experiment, two
congruent audio-visual digital art videos were used as stimuli to assess
their potential stress-relieving effects. A total of 24 participants were
invited to participate and were divided into 3 groups. To induce a stress
response in the participants, the Trier Social Stress Test was employed in
the experiment. Following this, two separate groups were shown videos with
different emotional tones, namely joy and sadness. The third group was the
control group. The study assessed changes in participants' stress levels
before and after the experiment using two tools: the State-Trait Anxiety
Inventory (STAI) and Empatica E4. According to the study, both happy and sad
videos were effective in reducing stress levels. The findings of this
research could inform the development of digital art as a potential tool for
stress management and emotional intervention.
Pengaruh Keringanan Sanksi Administrasi Undang-Undang Harmonisasi Peraturan Perpajakan terhadap Kepatuhan Wajib Pajak
Authors: Hany Sharah Puan , Mahandito Tasdik , Alsilana Vani , Nafi’ah Zahra Zuhrotun , Irawan Ferry
Published: July 2023

Undang-Undang Harmonisasi Peraturan Perpajakan (UU HPP) hadir dalam rangka merevisi peraturan perpajakan tak terkecuali Undang-Undang tentang Ketentuan Umum dan Tata Cara Perpajakan (UU KUP). Hal tersebut dilatari kemunculan pandemi Covid-19 yang berdampak pada perekonomian nasional. Besaran sanksi administrasi dalam UU HPP yang cenderung lebih ringan dibanding UU KUP menimbulkan hipotesis bahwa kepatuhan wajib pajak akan berkurang sejalan dengan berkurangnya sanksi yang dikenakan pada wajib pajak yang melanggar. Melalui pendekatan yuridis normatif dengan merumuskan kaidah-kaidah hukum yang berkaitan dengan sanksi administrasi pada UU KUP dan UU HPP, penelitian ini dilakukan dengan tujuan untuk mengetahui bagaimana pengaruh perubahan sanksi administrasi dalam UU HPP terhadap tingkat kepatuhan wajib pajak. Berdasarkan hasil penelitian yang telah dilakukan, dapat diketahui bahwa pengurangan sanksi administrasi yang diberikan dalam UU HPP berhasil meningkatkan kepatuhan wajib pajak, dalam hal ini merupakan kepatuhan sukarela yang mencerminkan tingkat kepercayaan yang baik oleh wajib pajak kepada otoritas pajak.
Menelaah Kenaikan Tarif Pajak Pertambahan Nilai Ditinjau dari Asas Keadilan
Authors: Novianto Rafiq Wahyu , Ramadhan Rendi Dwi Putra , Azzahra Safira Faradisa , Irawan Ferry
Published: July 2023

Pajak adalah kontribusi wajib kepada negara yang terutang oleh orang pribadi atau badan yang bersifat memaksa berdasarkan Undang-Undang, dengan tidak mendapatkan imbalan secara langsung dan digunakan untuk keperluan negara bagi sebesar-besarnya kemakmuran rakyat. Salah satu jenis pajak di Indonesia adalah Pajak Pertambahan Nilai (PPN). Pemerintah menaikan tarif Pajak Pertambahan Nilai (PPN) pada 2022 dengan tujuan untuk mendorong realisasi target penerimaan pajak dan sebagai upaya dalam pemulihan ekonomi di tahun 2022. kenaikan tarif PPN ini menimbulkan berbagai pro kontra dari berbagai pihak karena terjadinya perbedaan kepentingan di antara masing-masing pihak. Institusi pemungut pajak harus memperhatikan berbagai faktor dalam memungut pajak, salah satunya adalah asas pemungutan pajak. Asas keadilan merupakan salah satu asas terpenting yang harus kita pertimbangkan di saat memungut pajak. Permasalahan yang selalu didengungkan adalah adilkah pemerintah dalam melakukan pemungutan pajak. Penelitian ini bertujuan untuk membahas bagaimana kenaikan tarif pajak pertambahan Nilai (PPN) ditinjau dari asas keadilan.
Delivering substance use prevention interventions for adolescents in educational settings: A scoping review
Authors: Liu Xin-Qiao , Guo Yu-Xin , Wang Xin
Published: July 2023

A condition of exposure to multiple stressors resulting in a mixed clinical picture spanning conventional categories without meeting any of them in full, encompasses a risk for a list of comorbidities preventing appropriate prevention and treatment. New transformative transdiagnostic approaches suggest changes spanning conventional categories. They base their systems of classification on biomarkers as well as on brain structural and functional dysregulation as associated with behavioral and emotional symptoms. These new approaches received critiques for not being specific enough and for suggesting a few biomarkers for psychopathology as a whole. Therefore, they put the value of differential diagnosis at risk of avoiding appropriate derived prevention and treatment. Multiplicity of stressors has been considered mostly during and following catastrophes, without considering the resulting mixed clinical picture and life event concomitant stressors. We herewith suggest a new category within the conventional classification systems: The Complex Stress Reaction Syndrome, for a condition of multiplicity of stressors, which showed a mixed clinical picture for daily life in the post coronavirus disease 2019 era, in the general population. We argue that this condition may be relevant to daily, regular life, across the lifespan, and beyond conditions of catastrophes. We further argue that this condition may worsen without professional care and it may develop into a severe mental health disorder, more costly to health systems and the suffering individuals. Means for derived prevention and treatment are discussed.
TelePsychiatry: Mental Health Detection App using DASS42
Authors:   Fr. Conceicao Rodrigues College of Engineering, Shah Vrushti
Published: July 2023

Mental Health is such an issue that might arise due to quotidian errands or tasks rather than extravagant factors that might be considered as contributing symptoms for other disorders. Mental Health, albeit extremely crucial, is very inaccessible right now. Not everyone can have quick access to a doctor. There are those who, in spite of the stigma, are interested in improving their mental health. We want to help create a secure environment for people by implementing an application with DASS 42 that will help classify Depression, Anxiety and Stress for users based on their scores. In this application, we have incorporated an extensive, well-articulated questionnaire with the kind of questions that will help our system understand and evaluate the issue that the user is going through. The application aims at providing an eloquent environment to the users indicating their mental state.
Urgensi Pembentukan Karakter Religius Peserta Didik melalui Pembelajaran Al-Qur’an Hadits di Madrasah Ibtidaiyah
Authors: Fauziah Irma
Published: July 2023

This research is motivated by the fact that the decadence of the religious character of today's children does not reflect the nation's successors who are good and have good character. The purpose of this research is to describe the urgency of learning Al-Quran Hadith in forming religious character, methods of forming character as well as supporting and inhibiting factors in learning Quran Hadith at Madrasah Ibtidaiyah level. The method used in this research is the library research method. The data were obtained from books and scientific articles from the internet that were relevant to the research discussion. The data search method uses the Publish or Perish application to access data collections and sources of information from journals from the Crossref and Google Scholar databases by inputting the keywords "Character Building" and "Learning Al Quran Hadith Madrasah Ibtidaiyah". The data analysis technique was carried out using the Miles and Huberman stages. The results showed: 1) Al-Quran Hadith learning is important for the formation of the religious character of students, 2) Supporting factors for the formation of religious character include the support of parents, teachers and the community, as well as the existence of adequate facilities. While the inhibiting factors are innate character, family upbringing and non-educational environment. 3) The method of forming religious character through learning Al Quran hadith can be done by example and habituation, as well as fun learning methods.
Maximizing Accuracy: Advancements in Numerical Methods for Ordinary Differential Equations
Authors: Nupur Sanjida , Akter Reshma , Tamanna Tashmir Reza , Akter Parvin
Published: July 2023

Euler’s Method, Taylor’s Method are the most fundamental and easiest methods to solve first order ordinary differential equations (ODEs). Many other methods like Runge-Kutta Method have been developed on the basis of these method. In this paper, the basic ideas behind Euler's Method, Taylor's Method, and Runge-Kutta Method, as well as the geometrical interpretation have been discussed. The main focus is confined to the mathematical interpretation and graphical representation of these method and to find a way to reduce the errors. In order to verify the accuracy of these methods, we compare numerical solutions to exact solutions. Numerical experiment and graphical representation of a specific problem have been discussed in this paper. MATLAB programs have been used for graphical representation and FORTRAN programs have been used for computational efficiency.
La psicoterapia centrada en la persona en la actualidad: Teoría, práctica e investigación
Authors: Sabucedo Pablo
Published: July 2023

Enmarcada en la orientación humanista-existencial, y con más de ochenta años de historia, la psicoterapia centrada en la persona continúa siendo uno de los principales sistemas de intervención psicológica. Las ideas de su principal creador, Carl R. Rogers, han sido claves en el desarrollo de la investigación y el ejercicio de la psicoterapia tal y como la conocemos en la actualidad, tanto dentro como fuera de las fronteras de la orientación. Tras una introducción a la teoría psicopatológica y psicoterapéutica que subyace al sistema, este artículo se centra tanto en los nuevos desarrollos dentro de la teoría rogeriana como en la investigación llevada a cabo hasta el momento sobre ella. Revisando algunos de los debates centrales en el ámbito, desde la perspectiva del siglo XXI, el artículo concluye con una reflexión sobre la situación actual del sistema.
Liga de obstetrícia e saúde da mulher da FM - UFG e suas contribuições para os acadêmicos e para a população em geral
Authors: Heliodoro Taynara Luisa de Mello , Heliodoro Barbara Êmily de Mello , Berigo Joâo Alexandre da Costa , Camapum Emilson José de Souza , Marot Ricardo Pereira
Published: July 2023

Ligas acadêmicas são instituições que seguem o princípio da indissocialidade entre ensino, pesquisa e extensão, ratificado pelo artigo 207 da Constituição, criadas e organizadas por estudantes das Universidades, juntamente com um professor orientador e não têm fins lucrativos. Expor e avaliar as atividades de extensão e cultura realizadas; relatar a melhoria na formação científica, médica e social dos acadêmicos e pormenorizar os benefícios da população em atuações da LOBS. Estudo descritivo a partir da análise dos registros do livro ATA da LOBS, revisão das aulas, campanhas e projetos desenvolvidos no período entre agosto de 2016 a julho de 2017. Apresentado dadostividades de extensão, ensino e pesquisa. As faculdades brasileiras formadoras de profissionais de saúde ainda engatinham em aspectos importantes para a humanização e compreensão do homem como um todo. A LOBS, por meio de seus projetos de extensão, ensino e incentivo à ciência suplementa os acadêmicos tanto na área de estudo puramente teórica, quanto na prática supervisionada por profissionais já graduados.
Analisis Tingkat Kepuasan Pasien BPJS di Puskesmas Tanjung Botung Kabupaten Padang Lawas
Authors: Mhd. Idris Lubis  , Haslinah Ahmad  , Rusdiyah Sudirman Made Ali  , Anto J. Hadi  , Megawati
Published: July 2023

Latar belakang: Di Indonesia, program pemeliharaan kesehatan adalah sistem asuransi, yang dilaksanakan oleh pemerintah maupun swasta. Upaya yang dilakukan pemerintah dalam memberikan jaminan kesehatan untuk masyarakat seperti adanya Jaminan Kesehatan Nasional (JKN). Dalam hal ini dapat meningkatkan derajat kesehatan masyarakat, seperti telah diselenggarakannya program Jaminan Kesehatan Nasional (JKN) oleh Badan Penyelenggara Jaminan Nasional (BPJS) Kesehatan, sebagai upaya memberikan perlindungan kepada masyarakat dalam memperoleh pemeliharaan kesehatan dan memenuhi kebutuhan dasar kesehatan.

Tujuan: Tujuan penelitian ini adalah untuk menganalisis tingakt kepuasan pasien BPJS di Puskesmas Tanjung Botung Kabupaten Padang Lawas.

Metode: Jenis penelitian adalah observasional dengan pendekatan cross section study. Populasi dalam penelitian ini adalah pasien BPJS sebanyak 713 dan sampel dalam penelitian ini adalah pasien yang menggunakan BPJS dan di ambil dengan menggunakan accidental sampling sebanyak 116. serta uji statistik menggunakan chi-square dan regresi logistik.

Hasil: Penelitian menunjukkan bahwa daya tanggap (p=0,001), kehandalan (p=0,003), empati (p=0,001), dan bukti fisik (p=0,012) adalah variabel yang berhubungan dengan tingkat kepuasan pasien bpjs, sedangkan variabel jaminan (p=0,411) tidak berhubungan dengan tingkat kepuasan pasien bpjs. Selain itu daya tanggap yang paling berhubungan dengan tingkat kepuasaan pasien dengan nilai Exp (B)=3,816.

Kesimpulan: diperoleh bahwa daya tanggap, kehandalan, empati, bukti fisik merupakan factor kepuasan pasien. Sehingga diperlukan usaha pelayanan kesehatan prima untuk meningkatkan kualitas pelayanan pasien BPJS.
Analisis Faktor Kejadian TB Paru di Wilayah Kerja Puskesmas Pasar Ujungbatu Kabupaten Padang Lawas Tahun 2023
Authors: Regina Junisna Waldani  , Owildan Wisudawan  , Haslinah Ahmad
Published: July 2023

Latar belakang: Tuberculosis sampai dengan saat ini masih menjadi masalah kesehatan masyarakat utama di dunia dan Indonesia walaupun upaya penanggulangan TB telah dilaksanakan di banyak negara sejak tahun 1995.

Tujuan: Tujuan penelitian ini adalah untuk menganalisis faktor kejadian TB paru di wilayah kerja puskesmas pasar ujungbatu kabupaten padang lawas.

Metode: Jenis penelitian adalah kuantitatif dengan menggunakan desain penelitian cross section study. Populasi penelitian ini adalah seluruh suspek di, Tahun 2021 dan tahun 2022 yang menunjukaan gejala tuberkulosis paru sebanyak 101 orang di wilayah kerja Puskesmas Pasar Ujungbatu dengan teknik pengambilan sampel adalah total sampling sehingga jumlah sampel sama dengan jumlah populasi yaitu 101 dengan uji statistik menggunakan chi-square dan regresi logistic.

Hasil: Hasil penelitian diperoleh bahwa pengetahuan (p=0,010), sikap (p=0,001), dan kelembapan rumah (p=0,001) adalah variabel yang berpengaruh dengan kejadian TB paru. Variabel pendapatan (p=0,924) tidak berpengaruh dengan kejadian TB paru serta kelembapan rumah yang paling berpengaruh terhadap kejadian TB paru dengsn nilai Exp (B) =4.869.

Kesimpulan: Kesimpulan diperoleh bahwa kejadian TB paru dipengaruhi oleh faktor pengetahuan, sikap, serta kelembapan rumah sehingga diperlukan komunikasi, informasi dan edukasi pada keluarga atau masyarakat terkait TB paru.
Abdominal Elephantiasis: An Obstructive Disease Due to Extreme Obesity
Authors: Mohajan Devajit , Mohajan Haradhan Kumar
Published: July 2023

This study deals with abdominal elephantiasis disease due to extensive lymph node destruction by erysipelas. The disease is rare, and only seen in developed countries among unfortunate morbid obese (e.g., BMI is in the range 60 to 80 or above) individuals. Abdominal elephantiasis is viewed as by chronic inflammation and obstruction of the lymphatic channels, and by hypertrophy of the skin and subcutaneous tissues. This mini review tries to make conscious about the negative effects of extreme obesity.
Reading poetry based on video modeling techniques of poetry performance records
Authors: Rahmawati Aenun
Published: July 2023

Background:  Reading poetry is an effort to convey the poet's message to his listeners.
Purpose: This study aims to analyze the process of learning to read poetry and improve results.
Design and methods: This experiment analyzes the improvement of the learning process, including the stages of attention, retention, reproduction, and motivation, as well as the improvement of student learning outcomes when reading poetry in terms of intonation, pronunciation, volume, gestures, and expressions. This research was conducted on Literary Club extracurricular students at SDIT ALIF. The method used in this study is a quantitative experimental method using the video modeling technique of recording a poetry performance by Helvy Tiana Rosa. Data analysis techniques in this study were in the form of videos during which students read poetry, observation sheets, field notes, and student test results in the form of performance tests. In this design, two groups are randomly selected and then given a pretest to find out the difference in the initial state between the experimental group and the control group. Each group that was randomly selected was the same for both the control group and the experimental group, namely 10 people
Results: experimental class pretest data with an average of 14.10 while the control class obtained an average of 19.60. From the results of the posttest, it was obtained that the average posttest score of the experimental class was 17.50 and that of the control class was 26.30. Thus, it can be said that the skills of students have increased. However, based on the assessment with this technique, there is an insignificant increase in effect
Impact Of Ethical Leadership on Work Engagement Via Perceived Organizational Politics; Moderating Role of Locus of Control
Authors: Gill Aniqa , Danish Rizwan Qaiser , Ramzan Muhammad
Published: July 2023

Around 88 percent of the managers across the globe reported that politics, an endemic phenomenon exists in their organizations and around 87 percent employees are not completely engaged at work. Considering these emergent issues, the purpose of this paper is to examine the effect of ethical leadership on work engagement through perceived organizational politics, while considering locus of control as moderator in the association between perceived organizational politics and work engagement. This paper utilized a cross-sectional survey research design from 500 supervisor-supervisee dyads in both private and public service sectors of Lahore. Confirmatory factor analysis validated the dimensionality as well as reliability of the measurement model. Furthermore, the hypothesized associations were analyzed through two-staged structural equation modeling. Results revealed that perceived organizational politics mediates the association between ethical leadership and work engagement. In addition, locus of control was found to moderate the association between perceived organizational politics and work engagement. This paper did not establish any causal inferences between the constructs, therefore explanation pertinent to findings must be provided with great caution. This paper suggests practical inferences through mitigation of damaging effects of perceived organizational politics, a prevailing issue with deleterious outcomes and yet not addressed in Asian societies organizations. It emphasizes on organizations to recruit and train individuals with ethical behaviors that may help avoid employees’ negative perceptions, resulting in increased employees’ work engagement. This study extends the existent literature through examining perceived organizational politics (POP) as a mediating mechanism between ethical leadership and work engagement. It sheds light on the personality, politics as a psychological state with its outcomes, along with the cultural dimension for the first time in literature and explains the phenomena through which negative effects of (POP) are buffered by ethical leadership while in presence of individual differences that ameliorate or deteriorate the organizational outcomes. The theoretical framework is progressed through social learning theory and COR theory.
Investigating the Policy Priority of Sustainable Livelihood of Small-Scale Fishing Household: Evidence During the Pandemic from Prigi Bay, Trenggalek, Indonesia
Authors: Purwanti Pudji , Fattah Mochammad , Qurrata Vika Annisa , Sulistyono Agus Dwi , Saputra Jumadil
Published: July 2023

The development of coastal fisheries in the Trenggalek regency area is growing rapidly due to technological advancement. Technology has become a stimulant for the community in utilizing fishery resources. The sustainability of the livelihoods of fishing communities in Prigi Bay in 2019 was analyzed using the sustainable livelihood approach (SLA), showing that social capital during the COVID-19 pandemic experienced changes in social and economic aspects. According to previous SLA results, this study examines the policy priorities of small-scale fishing households in Prigi Bay. This study investigates the policy priorities to improve the sustainability of fishers’ livelihoods using the analytical hierarchy process (AHP) criteria. The analysis results indicate that local culture is consequential and greatly impacts household sustainability. It is due to the custom, which maintains culture of not going to catch fish on Fridays. The culture has not been drafted as a local regulation. Therefore, the local government should draft regional regulations regarding the clean sea program on Fridays that all coastal communities must follow. It will affect the fishers’ sustainable livelihood because production activities are not only in the sea but also outside the sea. For example, people could perform off-fishing activities such as planting crops and maintaining social relationships with family or neighbours.
Optimization of Total Carotenoid Production by Rhodotorula mucilaginosa from Artichoke Agroindustrial Waste Using Response Surface Methodology
Authors: Terrones Rodríguez Nicole Alejandra , Quiñones-Cerna Claudio Eduardo , Robles Castillo Heber Max , Cruz-Monzon Jose Alfredo , Hurtado Butrón Fernando Javier , Rodríguez Soto Juan Carlos
Published: July 2023

The carotenoids have vast medical, industrial, dietary, and pharmaceutical importance due to their provitamin A precursor, immunomodulator, antioxidant and photoprotective activity. The purpose of the research was to optimize the production of carotenoids using Rhodotorula mucilaginosa from artichoke agroindustrial waste as a low-cost substrate. The artichokes bracts waste was bleached by sodium hypochlorite (NaClO 2%) and was characterized through whiteness index and FTIR. The bleached artichoke waste (BABW) used in the fermentation went through acid hydrolysis, applying 8% of the bleached artichokes residue and sulfuric acid (2.5%) for 1 h at 90°C, obtaining a greater reduced sugars content at 3.1 g/L. Rhodotorula mucilaginosa was isolated and molecularly identified. The production of carotenoids from a culture media based on hydrolyzed BABW, peptone (0.5%), yeast extract (0.1%) and sodium chloride (0.5%) was evaluated at different conditions of pH (5–8) and agitation speed (80–160 rpm) applying the surface response methodology by a rotational central compound design. The best carotenoids performance obtained had 2968.95 µg/L VVC and 1228.53 µg/g TFC at pH 5, 120 rpm and 30°C for 72 h. The chemical characterization of the extracted carotenoids was confirmed by UV-VIS and Raman spectroscopy methods. The results suggest that Rhodotorula mucilaginosa is capable of producing carotenoids from artichoke waste fermentation, providing a low-cost and sustainable alternative route for use in the global market.
Ultrasound-assisted liquefaction of honey
Authors:   , Kabbani Dania
Published: July 2023

Crystallization of honey is a common process of the honey industry. Liquid honey is preferred by most of the consumers and by food companies for ease of handling. Honey is commonly heated during pasteurization in order to liquefy it and inhibit any microbial growth. However, heating can degrade the main quality parameters of honey.
A better method compared to expensive and time-consuming heating is desirable to pasteurize, accelerate the liquefaction and retard the crystallization process in honey.
The present thesis documents the work done at investigating the effect of the ultrasounds (US) in honey liquefaction, quality alteration and honey decontamination.
Firstly, in Chapter 1, the effect of different combinations of US treatment (power, temperature and duration) on honey liquefaction were evaluated by studying the rheological properties of honey; viscosity behaviour, crystal content, tendency to re-crystallization and thermal properties. Secondly, in Chapter 2, the effects of US on the hydroxymethylfurfural concentration and diastase activities in honey were determined by chemical analysis and compared with that for standard heat-treated honey samples. Thirdly, in Chapter 3, US treatment was investigated for honey decontamination. In addition, the in vitro antimicrobial and antifungal activities of ultrasonicated honey against several types of microorganisms were evaluated.
The results obtained in this research point to a successful application of the ultrasound technology for the liquefaction of honey, as it speeds up its liquefaction, do not degrade the quality and the intrinsic biological activity of honey was neither affected.
Goldschmidt and Social Theory
Authors: Silver Daniel ,   DePaul University
Published: July 2023

The concepts of contradiction and dialogue are crucial to Hermann Goldschmidt’s Contradiction Set Free. In this paper, I place Goldschmidt into dialogue with two social thinkers for whom similar ideas were equally crucial: Georg Simmel and Donald Levine. In the case of Simmel, I highlight his theory of conflict specifically, but more generally his commitment to duality and ambiguity. In the case of Levine, I feature his attempt to articulate what he calls a “dialogic” narrative of the sociological tradition. I seek to evaluate Goldschmidt’s own thinking by his own criteria, by asking whether the sociological and the philosophical approaches to these questions are parallel, in opposition, or an instance of a contradiction in Goldschmidt’s sense.
Peran Pemuda Sebagai Pelopor Moderasi Beragama Mewujudkan Kabupaten Tanah Bumbu Menuju Serambi Madinah dalam Perspektif Islam
Authors: Irfala Azmi
Published: July 2023

Kabupaten Tanah Bumbu sebagai daerah dengan masyarakat yang beragam. Keragaman mencakup perbedaan suku, agama, budaya-tradisi dan sebagainya. Keragaman ini tentunya harus terus dirawat dalam bingkai moderasi beragama oleh masyarakat, terutama pemuda. Tujuan penulisan ini adalah membahas peran pemuda sebagai pelopor moderasi beragama untuk mewujudkan Kabupaten Tanah Bumbu menuju Serambi Madinah. Metode yang digunakan adalah deskripsi analitis penelitian pustaka. Kesimpulan kajian ini adalah bahwa peran pemuda dalam menjaga kehidupan multikultural diperlukan pemahaman dan kesadaran menghargai perbedaan, kemajemukan dan kemauan berinteraksi dengan siapapun secara adil dengan menanamkan nilai-nilai kearifan lokal Baiman Baadab Bauntung Batuah, yang kemudian diterapkan dalam kehidupan. Pemuda harus produktif dan inovatif untuk mensosialisasikan, menumbuhkembangkan moderasi beragama kepada masyarakat demi terus terjaganya keharmonisan di Kabupaten Tanah Bumbu menuju Serambi Madinah.
Analisis Faktor Peningkatan Pakan Ayam Petelur PT. Japfa Comfeed Indonesia Tbk. Menggunakan Grounded Theory
Authors: Ariati Ira
Published: July 2023

One of the determining factors for the success of laying hens is the availability of feed that is suitable for livestock needs, both in terms of quantity and quality. This will also be closely correlated with the costs incurred, the more efficient the use of feed, the greater the income of farmers can be. Feed is one of the important components that determine success in laying hens cultivation. In addition to having a direct effect on production performance, feed costs are the biggest costs that must be incurred. This study uses a qualitative technique with a grounded theory approach. The author conducted direct interviews with PT Japfa Comfeed Indonesia Internal, Tbk. and from External Parties (Ministry of Animal Husbandry, Ministry of AgriculturMMe, and Ministry of Trade) to determine the impact of rising corn prices on feed prices. Results Based on the research, it was found coding scheme consisted of 21 codes that formed 14 categories and gave rise to 3 themes with a total score of 36. The biggest score in coding was 16 on the theme of increasing production operational costs so that the factor that greatly influenced the increase in the price of CAL-9 laying hens at PT Japfa Comfeed Indonesia Tbk was the increase in production operating prices.
Penyuluhan Media Leaflet dan Video Animasi Tentang Pentingnya Kesehatan Gigi Mulut Pengunaan dan Pembuatan Gigi Tiruan pada Siswa-Siswi dan Guru
Authors: Marsigid Didik , Maesaroh Imas , Tasrip Tasrip
Published: July 2023

The use of dentures as a substitute for missing teeth is very important, but not everyone with missing teeth wears dentures. Dental and oral health education is an effort to convey messages about dental and oral health. Dental and oral health education requires facilities in the form of educational media, because it can facilitate the delivery of information. Students and teachers at the Assa'adah Orphan Islamic Boarding School in the Kebayoran Baru area, South Jakarta are the right target considering that orphaned and dhuafa adolescents are teenagers from a disadvantaged economic class and are in their infancy who need maintenance of dental health and prevention of tooth decay and repair if you have lost your teeth by making dentures so that they can improve masticatory and aesthetic functions. The purpose of this community service is to improve masticatory and aesthetic functions for SMPI Students and Teachers of the Orphan Islamic Boarding School Assa'adah Jakarta The method of implementing this community service is carried out by conducting counseling with animated video media and leaflet media about the importance of oral health in the use and manufacture of dentures. This activity was attended by 110 students consisting of 55 counseling students on video media methods and 55 students on leaflet media counseling. The results achieved were an increase in knowledge before and after counseling with animated video media with a pre-test score of 387 post test 518 an average score of 9.42 for Leaflet media has a pre-test score of 358, posttest has an average score of 8.1. The conclusion is that there are differences in the knowledge of the post-test group and the animated video media group and the leaflet media with the results of the Independent Sample T-Test different test, it is obtained that the value of Sig.(2-tailed) ) of 0.000 <0.05.