bluuebunny/crossref_metadata_2025 huggingface dataset:
Malignancy in Solitary Thyroid Nodules: Evaluation of Risk Factors
Authors: Uyar Osman , Cetin Bahadır , Aksel Bulent , Dogan Lutfi , Beksac Kemal , Akgul Gokhan G. , Berberoglu Ugur , Gulcelik Mehmet A.
Published: May 2017

Background: The aim of the present study was to evaluate patients with suspicious solitary nodules undergoing bilateral total thyroidectomy for the presence of malignancy. Patients and Methods: 141 patients with true solitary thyroid nodules who underwent bilateral total thyroidectomy at the Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital between 2008 and 2013 were retrospectively evaluated. Parameters including demographics, ultrasonographic findings, and laboratory values were analyzed. Results: When the final pathology results were evaluated, malignancy was found in 52/141 (36.9%) patients. 49 (94.2%) of these lesions were papillary carcinoma. Colloidal nodules accounted for 30.3% of all benign cases. Nodular irregularity, increased vascularity, microcalcification, and central/lateral lymphadenopathy significantly increased the risk of malignancy. Among these factors, increased vascularity was the most important risk factor and microcalcification the second. Nodule size did not affect the risk of malignancy. Conclusion: Irregular borders, microcalcification, increased vascularity, and detection of cervical lymphadenopathy were found to be correlated with malignancy in solitary nodules.
Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases
Authors: Totté Joan E.E. , van Doorn Martijn B. , Pasmans Suzanne G.M.A.
Published: May 2017

Staphylococcus aureus plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis. Bacterial resistance against commonly used antibiotics has increased considerably in the last decades demanding alternative treatment approaches. We present 3 cases where patients with chronic and recurrent S. aureus-related dermatoses were successfully treated with Staphefekt SA.100. Staphefekt SA.100 is a recombinant phage endolysin for topical skin application that specifically targets both methicillin-sensitive and methicillin-resistant S. aureus. As a consequence of its specific mechanism of action, bacterial resistance is unlikely to develop. In our 3 cases, resistance induction was not observed. Our results indicate that targeted treatment with Staphefekt might be an attractive alternative for (long-term) classical antibiotic therapy, and confirmatory randomized controlled trials are warranted to evaluate its clinical efficacy and safety.
Dual Inhibition of EGFR and VEGF in Heavily Pretreated Patients with Metastatic Colorectal Cancer
Authors: Larsen Finn Ole , Markussen Alice , Nielsen Dorte , Colville-Ebeling Bonnie , Riis Lene B. , Jensen Benny V.
Published: May 2017

Objective: The aim of this study was to evaluate the efficacy and safety of combining irinotecan, bevacizumab, and cetuximab/panitumumab as a 4th-line treatment in patients with metastatic colorectal cancer. Methods: All patients had KRAS wild-type metastatic colorectal cancer and had previously received fluoropyrimidine, oxaliplatin, irinotecan, and cetuximab/panitumumab in a 1st, 2nd, and 3rd line setting. Most patients had previously received bevacizumab as well. All patients had progressed within 3 months after the last given treatment before starting the triple combination therapy every second week. Results: Sixty-three patients were evaluated. The triple combination therapy was well tolerated. The median progression-free survival was 6.1 months, and the median overall survival was 11.9 months. Four patients (6%) obtained a partial response, and 40 (63%) had stable disease. Conclusion: The combination of irinotecan, bevacizumab, and cetuximab/panitumumab is safe and shows a toxicity profile corresponding to what is expected from the agents alone. The results indicate that the combination in the 4th line may result in a high rate of disease control in heavily pretreated patients with metastatic colorectal cancer.
Conventional versus Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymph Adenopathies: A Randomized Controlled Trial
Authors: Bonifazi Martina , Tramacere Irene , Zuccatosta Lina , Mei Federico , Sediari Michele , Paonessa Maria Cristina , Gasparini Stefano
Published: May 2017

Background: Conventional transbronchial needle aspiration (c-TBNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are both valuable diagnostic techniques for the diagnosis of hilar/mediastinal lesions. Although a superiority of EBUS-TBNA over c-TBNA may be expected, evidence-based data on a direct comparison between these 2 procedures are still lacking. Objectives: We aimed to test the superiority of EBUS-TBNA over c-TBNA in a randomized trial and to evaluate the cost-effectiveness profile of a staged strategy, including c-TBNA as initial test followed by EBUS-TBNA, in case of inconclusive results at rapid on-site evaluation. Methods: Eligible patients were randomized 1:1 to either the EBUS-TBNA or c-TBNA group. The primary endpoint was to test the superiority of EBUS-TBNA sensitivity over c-TBNA. The secondary endpoints included the sensitivity of the staged strategy, as well as costs and safety related to each procedure and to their sequential combination. Results: A total of 253 patients were randomized to either EBUS-TBNA (n = 127) or c-TBNA (n = 126), and 31 patients of the c-TBNA group subsequently underwent EBUS-TBNA. The sensitivity of EBUS-TBNA was higher, but not significantly superior to that of c-TBNA (respectively. 92% [95% CI 87-97] and 82% [95% CI 75-90], p > 0.05). The sensitivity of the staged strategy was 94% (95% CI 89-98). No major adverse events occurred. Conclusions: EBUS-TBNA was the single best diagnostic tool, although not significantly superior to c-TBNA. Due to the favorable cost-effectiveness profile of their sequential combination, in selected scenarios with a high probability of success from the standard procedure, these should not be necessarily intended as competitive and the staged strategy could be considered in clinical practice.
A Comparison between Intermittent Peritoneal Dialysis and Automatic Peritoneal Dialysis on Urgent Peritoneal Dialysis
Authors: Wang Chang , Fu Xiao , Yang Yuan , Deng Jun , Zhang Hong-qing , Deng Hong-mei , Lu Jia , Peng Youming , Liu Hong , Liu Fu-you , Liu Yinghong
Published: May 2017

Background: Urgent-start dialysis is a major problem for incident dialysis population. Urgent start on hemodialysis is associated with an increased risk of infectious or mechanical complications, and its mortality is equal to or higher than that of urgent start on peritoneal dialysis (PD). However, compared to patients starting PD in a planned setting, those on urgent-started PD have an increased risk of mechanical complications and lower technique survival. Methods: In this study, 101 adult incident dialysis patients (≥18 years old) who underwent Tenckhoff catheter implantation were enrolled. All of the patients were grouped according to the urgent PD mode: the intermittent PD (IPD) or automatic PD (APD) group, and patients were followed for 1 year. The paired or independent t test was used to analyze the change of laboratory variables. Pearson chi-square test was applied to compare the short outcome between the 2 groups. Results: When PD was treated for 7 days and 1 month, the APD group has the lower serum potassium and phosphorus levels than the IPD group. The incidence of catheter dysfunction was significantly lower in the APD group. The morbidity of infection associated with PD in the first year was lower in the APD group despite no significant difference existing. The technique survival and patient survival rate have no evident difference between the 2 groups. Conclusion: Compared to IPD, urgent start on APD could reduce the risk of mechanical complication, which could be considered a gentle, safe, and feasible alternative to urgent start on IPD.
Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular Response to Oxidative Stress
Authors: Angori Silvia , Capanni Cristina , Faulkner Georgine , Bean Camilla , Boriani Giuseppe , Lattanzi Giovanna , Cenni Vittoria
Published: May 2017

Background: Ankrd2 is a stress responsive protein mainly expressed in muscle cells. Upon the application of oxidative stress, Ankrd2 translocates into the nucleus where it regulates the activity of genes involved in cellular response to stress. Emery-Dreifuss Muscular Dystrophy 2 (EDMD2) is a muscular disorder caused by mutations of the gene encoding lamin A, LMNA. As well as many phenotypic abnormalities, EDMD2 muscle cells also feature a permanent basal stress state, the underlying molecular mechanisms of which are currently unclear. Methods: Experiments were performed in EDMD2-lamin A overexpressing cell lines and EDMD2-affected human myotubes. Oxidative stress was produced by H2O2 treatment. Co-immunoprecipitation, cellular subfractionation and immunofluorescence analysis were used to validate the relation between Ankrd2 and forms of lamin A; cellular sensibility to stress was monitored by the analysis of Reactive Oxygen Species (ROS) release and cell viability. Results: Our data demonstrate that oxidative stress induces the formation of a complex between Ankrd2 and lamin A. However, EDMD2-lamin A mutants were able to bind and mislocalize Ankrd2 in the nucleus even under basal conditions. Nonetheless, cells co-expressing Ankrd2 and EDMD2-lamin A mutants were more sensitive to oxidative stress than the Ankrd2-wild type lamin A counterpart. Conclusions: For the first time, we present evidence that in muscle fibers from patients affected by EDMD2, Ankrd2 has an unusual nuclear localization. By introducing a plausible mechanism ruling this accumulation, our data hint at a novel function of Ankrd2 in the pathogenesis of EDMD2-affected cells.
Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma
Authors: Hieronimus Bettina , Pfohl Julian , Busch Christian , Graeve Lutz
Published: May 2017

Background/Aims: Membrane-type matrix metalloproteinases (MT-MMPs) are expressed on the cell surface and hydrolyze extracellular matrix components and signaling molecules by which they influence cancer cell migration and metastasis. Two of the six known MT-MMPs are anchored to the plasma membrane via a GPI anchor, one of which is MT4-MMP. Only little is known about MT4-MMP expression, synthesis, regulation and degradation. Methods: We analyzed several human cancer cell lines as well as tissue homogenates using Western blotting and quantitative PCR for the expression of MT4-MMP. Organelles of SK-Mel-28 cells were separated using continuous Iodixanol gradients. Glycosylation of the SK-Mel-28 protein was studied via glucosidases and site directed mutagenesis of the MT4-MMP cDNA prior to transfection. Results: We found the MT4-MMP highly expressed in human melanoma cell lines as well as skin and melanoma tissue samples. Three forms of MT4-MMP with molecular masses of 45 kDa, 58 kDa and 69 kDa were detected. Further, we demonstrate that the 58 kDa form is the mature protein in the cell membrane, while the 69 kDa form is its precursor found in intracellular compartments. The 69 kDa forms are processed by furin cleavage in the Golgi apparatus. Moreover, we identified Asn318 as the single N-glycosylation site of MT4-MMP. Conclusion: We demonstrate the novel expression of MT4-MMP in melanocytic tissues and propose a precursor/product-relationship of the different forms of MT4-MMP in melanoma cells.
Routine Monitoring of Sodium and Phosphorus Removal in Peritoneal Dialysis (PD) Patients Treated with Continuous Ambulatory PD (CAPD), Automated PD (APD) or Combined CAPD+APD
Authors: Moor Veronika , Wagner Robert , Sayer Michael , Petsch Marlies , Rueb Sandra , Häring Hans-Ulrich , Heyne Nils , Artunc Ferruh
Published: May 2017

Background: Adequate removal of sodium (Na) and phosphorus (P) is of paramount importance for patients with dialysis-dependent kidney disease can easily quantified in peritoneal dialysis (PD) patients. Some studies suggest that automated PD (APD) results in lower Na and P removal. Methods: In this study we retrospectively analysed our data on Na and P removal in PD patients after implementation of a routine monitoring in 2011. Patients were stratified in those treated with continuous ambulatory PD (CAPD, n=24), automated PD (APD, n=23) and APD with one bag change (CAPD+APD, n=10). Until 2015 we collected time-varying data on Na and P removal from each patient (median 5 [interquartile range 4-8] values). Results: Peritoneal Na and P removal (mmol per 24h ± standard deviation) was 102 ± 48 and 8 ± 2 in the CAPD, 90 ± 46 and 9 ± 3 in the APD and 126 ± 39 and 13 ± 2 in the CAPD+APD group (ANOVA P=0.141 and <0.001). Taking renal excretion into account total Na and P removal (mmol per 24h) was 221 ± 65 and 16 ± 5 in the CAPD, 189 ± 58 and 17 ± 6 in the APD and 183 ± 38 and 16 ± 6 in the CAPD+APD group (P=0.107 and 0.764). Over time, peritoneal removal of Na but not that of P increased in all groups. In patients with modifications of PD treatment, Na but not P removal was significantly increased over-time. Conclusions: Overall Na and P removal were similar with different PD modalities. Individualized adjustments of PD prescription including icodextrin use or higher glucose concentration can improve Na removal while P removal is mainly determined by the dialysate volume.
Factors Associated with Blood Pressure Variability Based on Ambulatory Blood Pressure Monitoring in Subjects with Hypertension in China
Authors: Li Wei , Yu YanXia , Liang Dehong , Jia En-Zhi
Published: May 2017

Background/Aims: We examined the factors associated with blood pressure variability in a multi-ethnicity prospective study in China to gain more evidence to guide the prevention and management of hypertension through risk factor intervention. Methods: A total of 318 consecutive adult subjects aged 29-94 years with suspected or known hypertension were enrolled in this study. Blood pressure variability measurements were based on ambulatory blood pressure monitoring. To measure short-term reading-to-reading blood pressure variability in this study, we used the standard deviation(SD) of the blood pressure to estimate the blood pressure variability. Results: The SDs of the blood pressure in this study ranged from 5.425 to 32.25, with a median of 10.81 (quartile range, 8.90–12.46). No significant difference regarding the level distribution of blood pressure variability was found across the various ethnicities. Spearman correlation analyses indicated that the SD of blood pressure was positively correlated with DSBP (r=0.302, p=<0.001), NSBP (r=0.383, p=<0.001), NDBP (r=0.230, p=<0.001), and FBG (r=0.129, p=0.023) and was negatively correlated with triglyceride (r=-0.289, p=<0.001), CR (r=-0.242, p=<0.001), HDL-C (r=-0.230, p=<0.001), LDL-C (r=-0.186, p=0.001), and apolipoprotein B levels (r=-0.157, p=0.006). Multiple linear regression analysis indicated that triglycerides (β=-0.217, p=<0.001), NSBP (β=0.174, p=0.003), FBG (β=0.128, p=0.024), DDBP (β=-0.128, p=0.022), and apolipoprotein A (β=-0.116, p=0.036) were significantly and independently associated with the blood pressure variability. Conclusions: In this study, blood pressure variability was significantly associated with not only blood pressure levels but also patient demographic, clinical and biochemical characteristics.
Evaluation of Absolute Serum Creatinine Changes in Staging of Cirrhosis-Induced Acute Renal Injury and its Association with Long-term Outcomes
Authors: Zhou Fangfang , Luo Qun , Han Lina , Yan Huadong , Zhou Wenhong , Wang Zemin , Li Yumei
Published: May 2017

Background/Aims: To assess the prognostic accuracy of absolute serum creatinine (sCr) changes (‘Delta-sCr’) on the long-term outcomes in cirrhotic patients, and evaluate the performance of the ‘Delta-sCr’ approach to stage acute kidney injury (AKI), compared with the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Methods: We conducted a retrospective analysis of 333 hospitalized patients. We classified AKI stages using two methods: 1) KDIGO AKI criteria; 2) ‘Delta-sCr’ system, defined by the difference between the baseline and the peak sCr value during the hospitalization. The end point was the hazard of 1-year death. Results: The prevalence of AKI in cirrhotic patients was 18.01% by the KDIGO criteria, and 25.22% by the ‘Delta-sCr’ system. On multivariable Cox hazard analysis, both of the two methods were independent predictive factors of death (‘Delta-sCr’ system: OR=2.911, p<0.001), (KDIGO criteria: OR=2.065, p<0.001). However, the ‘Delta-sCr’ system provided a modest improvement in classification over the KDIGO criteria with a net reclassification improvement (NRI) of 28.7% (p<0.001) and integrated discrimination improvement (IDI) of 7.5% (p=0.03). And the predictive value of the ‘Delta-sCr’ system could be significantly improved (p=0.006), when combined with age and MELD score. Conclusion: The Delta-sCr is associated with the 1-year mortality. And the ‘Delta-sCr’ system may optimize the discrimination of risk prediction.
Plasma ET-1 Concentrations are Elevated in Patients with Hypertension – Meta-Analysis of Clinical Studies
Authors: Xu Mei , Lu Yong-Ping , Hasan Ahmed Abdallah , Hocher Berthold
Published: May 2017

Background/Aims: A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. Methods: We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive patients where antihypertensive medication was discontinued for at least two weeks. Based on the principle of Cochrane systematic reviews, case control studies (CCSs) in PubMed (Medline) and Google Scholar designed to identify the role of endothelin-1 (ET-1) in the pathophysiological of hypertension were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects models. Results: Eleven studies fulfilling our in- and exclusion criteria were eligible for this meta-analysis. These studies included 450 hypertensive patients and 328 controls. Our meta-analysis revealed that ET-1 plasma concentrations were higher in hypertensive patients as compared to the control patients [mean difference between groups 1.57 pg/mL, 95%CI [0.47∼2.68, P = 0.005]. These finding were driven by patients having systolic blood pressure higher than 160 mmHg and diastolic blood pressure higher than 100 mmHg. Conclusions: This meta-analysis showed that hypertensive patients do have elevated plasma ET-1 concentrations. This finding is driven by those patients with high systolic/diastolic blood pressure. Given that the ET-1 gene did not appear in any of the whole genome association studies searching for hypertension associated gene loci, it is very likely that the elevated plasma ET-1 concentrations in hypertensive patients are secondary to hypertension and may reflect endothelial cell damage.
ЕКСПЕРТНА СИСТЕМА ВИБОРУ КОМПЛЕКСУ МЕТОДІВ ЛІКУВАННЯ ЗА МЕТОДИКОЮ ТРАДИЦІЙНОЇ КИТАЙСЬКОЇ МЕДИЦИНИ (КОНЦЕПЦІЯ „У-СІН”)
Authors: Vakulenko D. V. , Suhoniak І. І.
Published: May 2017

In this paper general aspects of designing expert systems for the choice of complex methods of treatment for patients on base of traditional china medicine, ESDD for Traditional Chinese Medicine (TKM). Implementing such a system would reduce the time to determine the methods of treatment, to use the experience gained in TCM, for treatment of diseases, improve the validity and quality of decision-making for treatment of diseases.
АНАЛІЗ ЕКСПЛУАТАЦІЙНИХ ХАРАКТЕРИСТИК БАЗИ ДАНИХ ІНФОРМАЦІЙНОЇ СИСТЕМИ ПЕРЕВІРКИ ЗНАНЬ У МЕДИЧНІЙ ОСВІТІ
Authors: Semenets A. V.
Published: May 2017

The purpose of this work is the analysis of the database performance parameters of the test knowledge information system in the medical education. The BLOB-fields usage follow the database tables fragmentation. The ASKS and ASK_ANSW tables average and real fragmentation levels are presented. The impact of the tables fragmentation level to the database performance was examined too. For this purpose the execution time was measured to the most important database query.
МОДЕЛЮВАННЯ ПРОЦЕСУ БЕЗОПЛАТНОГО ЗАБЕЗПЕЧЕННЯ ІНСУЛІНОМ ПАЦІЄНТІВ ІЗ ДІАГНОЗОМ ЦУКРОВИЙ ДІАБЕТ ІЗ ВИКОРИСТАННЯМ МЕТОДОЛОГІЇ STRUCTURE ANALYSIS AND DESIGN TECHNIQUE
Authors: Mintser O. P. , Banchuk M. V. , Kalinchuk S. V. , Diachenko S. O. , Belinskyi O. H.
Published: May 2017

The goal of the current project is the model creation for providing free prescript of insulin distribution with smart-car d usage based on the Cabinet of Ministers of Ukraine Resolution from 17.08.1998 № 1303. The work includes model creation with a help of system analysis tools (Structure Analysis and D esign Technique, SADT) by IDEF0-notation and CA BPwin 4.0 software usage.
ЗНАННЯ ОРІЄНТОВНІ ЗАСОБИ ПІДТРИМКИ ПРОЦЕСІВ ІНФОРМАЦІЙНОГО СУПРОВОДУ МЕДИЧНОГО ОБСЛУГОВУВАННЯ НАСЕЛЕННЯ
Authors: Mintser O. P. , Palahin O. V. , Petrenko M. H. , Velychko V. Yu. , Stryzhak O. Ye. , Tahere H.
Published: May 2017

Described approaches, models and facilities of forming of the systems of knowledges, by the s purpose of support of grant informatively consultative services at medical practice of doctor. Ontological models, facilities of linguistic analysis and visualization of reflection of objects of medical industry, are determined.
АСИМЕТРІЯ ГОЛОВНОГО МОЗКУ ПРИ АДАПТАЦІЇ ДО УМОВ ВИСОКОГІР'Я
Authors: Portnichenko V. I. , Kravchenko Yu. V. , Yevtushenko O. L. , Bakunovskyi О. М. , Yachnytsia І. О. , IIyin V. M.
Published: May 2017

Association between cerebral blood flow and higher nervous activity in people at different stages of adaptation to the midlands was studied. Investigation were performed before, during and after a three-week stay in the mountains at an altitude of 2100 m, as well as during short-term ups without the physical load on the height of 3900 m. In the initial period of adaptation to hypoxia desynchronization between the nerve processes in the cerebral cortex and brain blood flow was observed. There was an inversion and an increase in the asymmetry of cerebral blood flow in the direction of the dominance of the left hemisphere of the brain. After the three-week stay in the mountains asymmetry of cerebral blood flow was disappeared, blood flow to the brain was reduced, hemispheric symmetry was formed, and blood flow synchronized with the nerve processes in the cerebral cortex again was restored.
ІНФОРМАЦІЙНО-СТАТИСТИЧНІ ОЦІНКИ ПРИ ЗАСТОСУВАННІ FISH-МЕТОДУ ДЛЯ ВИЯВЛЕННЯ "ПРИХОВАНОГО" МОЗАЦИЗМУ СТАТЕВИХ ХРОМОСОМ СЕРЕД БЕЗПЛІДНИХ ПОДРУЖНІХ ПАР
Authors: Denysenko S. V.
Published: May 2017

The application of FISH-method on interphase cells with centromeric probes for chromosomes X and Y is described as used together with the traditional cytogenetic methods for the screening minor sex aneuploid cell lines among the couples with reproductive problems.
ПРОБЛЕМА ПОШУКУ МЕДИЧНОЇ ІНФОРМАЦІЇ В ЕЛКТРОННИХ ФАЙЛОВИХ АРХІВАХ ТА СТВОРЕННЯ ПОВНОТЕКСТОВИХ БАЗ ДАНИХ В КЛІНІЦІ ПРОФЕСІЙНИХ ЗАХВОРЮВАНЬ
Authors: Yashchenko A. B. , Yashchenko D. A.
Published: May 2017

The article outlines main problems of automated data search, application of databases and medical information systems in practice of medical institutions is presented. The practice of registration, storage of health information in electronic databases, structuring and analysis of data available is presented. Unspecialized retrieval systems for searching medical information in electronic file archives and creating full-text databases of medical records considering the relevance of found information have been tested. The advantages and disadvantages of various retrieval systems are reviewed, particularly at searching for Russian and Ukrainian full-text data arrays. The electronic file archives and databases of Ukrainian Research Institute of Industrial Medicine after nosology "radiculopathy" and "radiculomyelopathy” were used as the object of research.
НОВІ ДІАГНОСТИЧНІ ОЗНАКИ В КОМП'ЮТЕРНИХ СИСТЕМАХ ДІАГНОСТИКИ ФУНКЦІОНАЛЬНОГО СТАНУ СЕРЦЕВО-СУДИННОЇ СИСТЕМИ ЛЮДИНИ
Authors: Martsenyuk V. P. , Sverstiuk A. S. , Varyan N. V.
Published: May 2017

The new diagnostic criteria for the automatized cardiodiagnostics as the coefficients of the statistic assessment of synchronously registered cardiosignals in terms of trigonometric functions are analysed and suggested in the paper.
ІНСТРУМЕНТИ ПІДТРИМКИ ПРОЦЕСІВ АНАЛІТИЧНОЇ ДІЯЛЬНОСТІ ІНФОРМАЦІЙНИХ РЕСУРСІВ І ДЖЕРЕЛ
Authors: Mintser O. P. , Palahin O. V. , Velychko V. Yu. , Stryzhak O. Ye. , Tahere H.
Published: May 2017

There were described approaches, models and analytical tools support an expert in the analysis of distributed information resources. There were defined thesaurus model, as technological basis of linguistic analysis of subject areas. The examples of processing large quantities of documents related to the ecological state of the environment through the use of methods and systems logical-linguistic analysis.
ФАКТОРИ РИЗИКУ ТА ПРОГНОЗУВАННЯ ПЕРЕБІГУ ХІРУРГІЧНОГО ЛІКУВАННЯ У ХВОРИХ НА МІСЦЕВИЙ ПЕРИТОНІТ
Authors: Churpiy І. К.
Published: May 2017

The possibility of quantifying the risk factors of complications in the treatment of peritonitis. There are allocated 46 clinical features that are relevant to the prognosis of peritonitis.
МЕТОЛОГІЧНІ ПІДХОДИ ДО ВИЗНАЧЕННЯ ПОГЛИНУТОЇ ДОЗИ АЕРОЗОЛЮ ОКРЕМИМИ ДІЛЯНКАМИ ОРГАНІВ ДИХАННЯ
Authors: Kashuba М. О. , Fedoriv O. Ye.
Published: May 2017

New methodological approaches of determination of absorbed aerosol dose by some zone of respiratory tract were proposed. On the basis of the proposed solution is automatic control system that allows to determine the sorption capacity of some areas of respiratory organs.
КЛАСИФІКАЦІЯ ЗАКЛАДІВ ОХОРОНИ ЗДОРОВ'Я В ЗАВДАННЯХ МЕДИЧНОГО СТРАХУВАННЯ
Authors: Tverdokhlib О. І. , Horshkov Ye. V.
Published: May 2017

The article covers the implementing classification of medical institutions for the tasks of health insurance. A new approach to the systematization of medical institutions was proposed. This method is based on an assessment of the average cost per insured event.
ЗАСАДИ СТВОРЕННЯ ЄДИНОЇ ДЕРЖАВНОЇ СИСТЕМИ ІНФОРМАЦІЙНОГО ЗАБЕЗПЕЧЕННЯ ЗАКЛАДІВ ОХОРОНИ ЗДОРОВ'Я
Authors: Mintser O. P. , Babintseva L. Yu. , Banchuk M. V.
Published: May 2017

Principles of the new unified informative system of health care (UISHC) are considered. In the system unlike existent analogues the complex reflection of all factors influencing on the state of health, including environment, pharmaceutical factors etc are under discussion.Principles of formation of UISHC among which the most important is realization of duality (availability of stationary and mobile - medical electronic passport of a citizen) are also defined.
МОДЕЛЮВАННЯ МЕТОДИК РЕГІОНАРНОЇ АНЕСТЕЗІЇ ПІД УЛЬТРАЗВУКОВИМ КОНТРОЛЕМ НА ФАНТОМАХ З ЗАСТОСУВАННЯМ МЕТОДІВ СТАТИСТИЧНОГО АНАЛІЗУ
Authors: Bubnov R. V. , Hnatiuk L. S. , Synekop Yu. S.
Published: May 2017

The paper compares different techniques of needle insertion during phantom modeling of regional anesthesiaaffecting ultrasound visualization. A statistical analysis of experimental data for methodics optimization was conducted.
ГОМОМОРФІЗМ КОГНІТИВНИХ МОДЕЛЕЙ ПРЕДМЕТНОЇ ОБЛАСТІ ПРИ ПЕРЕДАЧІ ЗНАНЬ В ПІСЛЯДИПЛОМНІЙ ОСВІТІ
Authors: Krasnov V. V.
Published: May 2017

There is presented the notion of homomorphism cognitive domain subject models. The homomorphism criterion of cognitive models in domain knowledge transfer in the system of post-graduate medical education. Reasonable level of abstraction of the domain subject model, are substatiated.
КОРЕЛЯЦІЙНИЙ ПІДХІД ДО ОБГРУНТУВАННЯ ОПТИМАЛЬНИХ МОДЕЛЕЙ РОЗГАЛУЖЕННЯ МІКРОСУДИННИХ ВУЗЛІВ
Authors: Martsenyk V. P. , Vakulenko D. V. , Andrushchak I. Ye.
Published: May 2017

We conducted a survey in optimal vascular architectonics. An offered model of vascular bifurcations was tested on the study results available to us. The obtained values ф1 and ф2 correlated with the values obtained experimentally, the correlation coefficient was bigger 0.93, indicating the adequacy of the proposed model. The model of angles calculation vessels of torking with a diameter of 10 microns to 100 microns is correct and universal and normally complements Roux’s rule used in the model of Murray.
ВИКОРИСТАННЯ МЕТОДІВ МАТЕМАТИЧНОГО МОДЕЛЮВАННЯ ДЛЯ ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ ЕКСТРАКОРПОРАЛЬНОГО ЗАПЛІДНЕННЯ. ПОСТАНОВКА ПРОБЛЕМИ
Authors: Mintser O. P. , Denysenko S. V. , Lesnyak Yu. M.
Published: May 2017

There were presented the results of patterning a mathematical multifactor model of efficiency of the method of extracorporal fertilization.
ПЕРСПЕКТИВИ ДОСЛІДЖЕННЯ КРИСТАЛОГЕНЕЗУ РОТОВОЇ РІДИНИ В ДОКАЗОВІЙ ОРТОДОНТІЇ
Authors: Mintser O. P. , Tkachenko Yu. V. , Slobodskoy R. B. , Lytvynenko O. S.
Published: May 2017

The article provides a historic overview of research of micro-crystallization of saliva in complex diagnostics of dental diseases. Proceeding from results of their own and borrowed research, the authors demonstrate the principal qualitative parameters of comprehensive characteristics of fractal structures in the main layer of saliva facies. The article offers the algorithm of their evaluation and marks prospective trends in using software packages for objective qualitative assessment of fractals of micro-crystallograms of saliva in the case of norm or dental pathology.
ПОБУДОВА Й АНАЛІЗ МОДЕЛІ ПРИЙНЯТТЯ РІШЕНЬ ПРИ ОЦІНЦІ НАСЛІДКІВ ВАКЦИНАЦІЇ ПРОТИРОТАВІРУСНОЮ ВАКЦИНОЮ В УКРАЇНІ
Authors: Solovyov S. O. , Dziublyk I. V.
Published: May 2017

The results of computational and theoretical studies related to assessing of efficiency indicators of immunization with rotavirus vaccine in Ukraine among children under five years are presented. The Indicators of the impact were received with computer implementation of decision tree model based on Markov processes. Under strategies of vaccination and no vaccination projected levels of morbidity, number of hospital admissions, mortality of rotavirus infection and other factors were received. It was shown that the vaccination with rotavirus vaccine will have significant medical significance in Ukraine.
МАТЕМАТИЧНА МОДЕЛЬ ДЛЯ ПРОГНОЗУВАННЯ ЕФЕКТИВНОСТІ ПРАЦІ ПРИ МЕТЕОПАТИЧНИХ РЕАКЦІЯХ
Authors: Volkova N. M.
Published: May 2017

The article proposes a mathematical model to predict the effectiveness of mental work in healthy persons and detection of rejection in the case of reaction in terms meteopatychnoyi neyrotyzmu in points and functional parameters of autonomic regulation of heart rate.
ДОСЛІДЖЕННЯ КОНТАКТНОЇ ВЗАЄМОДІЇ ЦИЛІНДРИЧНИХ ТІЛ НА ПОХИЛОМУ ТРАНСПОРТЕРІ У ФАРМАЦЕВТИЧНІЙ ТЕХНОЛОГІЇ
Authors: Kravets N. O.
Published: May 2017

There was studied the percussive interaction of bodies rotation on transport lines of medicaments’ bottling on inclined conveyers. There were determined and substantiated the analytical dependences for finding out the maximum meanings of raprochement of different speeds of conveyer’s motion and glass packages type and size. There was shown that the typical time of determination of contact deformations by the statistic elasticity (Herts’ sum) is less than the typical time of interaction of glass packages, that confirms the usage correctness of statistic theory
КЛІНІЧНИЙ FUZZY-КОНТРОЛЕР В ОЦІНЦІ НЕЛІНІЙНИХ ОСОБЛИВОСТЕЙ ВАРІАБЕЛЬНОСТІ СЕРЦЕВОГО РИТМУ І ЛІКУВАННІ ГІПЕРТЕНЗИВНИХ УСКЛАДНЕНЬ ВАГІТНОСТІ
Authors: Sydorenko V. A. , Kutsenko V. P. , Vakulenko D. V. , Sverstyuk A. S. , Andrushchak I. Ye.
Published: May 2017

The choice of parameters of functional status of organism of pregnant, possibility and value of dynamic diagnostics of weight of preeklampsiya, is in-process examined, on the base of study of indexes of variability rhythm of heart of mother, allowing to get the current estimation of the state of the vegetative nervous system (VNS) of organism of pregnant, calculation of dosages of medicines and control of efficiency of the conducted therapy by means of algorithms of fuzzy logic. Formalization of set of entrance variables for managers
ПОРІВНЯЛЬНИЙ АНАЛІЗ ПОКАЗНИКІВ ЦЕНТРАЛЬНОЇ ГЕМОДИНАМІКИ У СПОРТСМЕНІВ-ДЗЮДОЇСТІВ ВИСОКОЇ КВАЛІФІКАЦІЇ В ЗАЛЕЖНОСТІ ВІД ВІКУ, КВАЛІФІКАЦІЇ ТА СТАЖУ ЗАНЯТЬ
Authors: Oleksenko І. М.
Published: May 2017

Research and analysis of indices of central hemodynamics are conducted in 101 sportsmen of high qualification, members of combined team of Ukraine on judo. The sizes of laboratory indices of integral reovazografy are set that are peculiar for the sportsmen-judoists divided for age, sports qualification and experience of training in judo
КЛІНІЧНІ АСПЕКТИ ОСТЕОСИНТЕЗУ ДІАФІЗАРНИХ ПЕРЕЛОМІВ СТЕГНА
Authors: Kovalchuk O. L. , Hrubar Yu. O. , Savchyshyn V. V.
Published: May 2017

The authrors made an analysis of treatment of 131 patients with fractures of diaphisal femur, determined the  frequency, ethiology, sex and age peculiarities of fractures of diaphisal femur. Authors established clinacal specificity of treatment of fractures of diaphisal femur in different mathods of ostheosyntesis.
ОПТИМІЗАЦІЯ ПРОГНОЗУВАННЯ РОЗВИТКУ АРТЕРІАЛЬНОЇ ГІПЕРТЕНЗІЇ НА ОСНОВІ КОМПЛЕКСНОГО ЗАСТОСУВАННЯ ІНФОРМАЦІЙНИХ МЕТОДИК ІЗ РОЗРОБКОЮ ДИФЕРЕНЦІАЛЬНО-ДІАГНОСТИЧНИХ КРИТЕРІЇВ ПРИ НАДАННІ ПЕРВИННОЇ МЕДИЧНОЇ ДОПОМОГИ
Authors: Martsenyuk V. P. , Selskyy P. R. , Selskyy B. P.
Published: May 2017

The paper describes the optimization of the prediction of disease at the primary health care level with a complex phased application of information techniques. The approach is based on analysis of the average values of indicators, correlation coefficients, using multi-parameter neural network clustering, ROC-analysis and decision tree.The data of 63 patients with arterial hypertension obtained at teaching and practical centers of primary health care were used for the analysis. It has been established that neural network clasterization can effectively and objectively allocate patients into the appropriate categories according to the level of average indices of patient examination results. Determination of the sensitivity and specificity of hemodynamic parameters, including blood pressure, and repeated during the initial survey was conducted using ROC-analysis.The diagnostic criteria of decision-making were developed to optimize the prediction of disease at the primary level in order to adjust examination procedures and treatment based on the analysis of indicators of patient examination with a complex gradual application of information procedures.
ІНДИВІДУАЛЬНЕ ЗДОРОВ'Я: У ПОШУКАХ СИСТЕМНОЇ ОЦІНКИ
Authors: Gavrylyuk V. O.
Published: May 2017

The article discusses possible approaches to the creation of a system of individual assessment of human health.
ВИВЧЕННЯ АДАПТАЦІЙНИХ МЕХАНІЗМІВ ПРИ КОМПРЕСІЇ ПЛЕЧА МАНЖЕТОЮ
Authors: Vakulenko D. V. , Vakulenko L. O. , Kutakova O. V.
Published: May 2017

It were studied the adaptive mechanisms of the organism to compression of shoulder with cuff. Shoulder compression during blood pressure measurements perceived by the body as stress. The adaptation of the body to the shoulder compression in young adults (18-20 years old) accompanied by an increased activity of peripheral, autonomic, hypothalamic-pituitary level of regulation of the cardiovascular system; but the activity of the central nervous system do not increasing. Extension studies using time and spectral analysis of ECG in various intervals will make it possible to re-use the obtained data to study the adaptive capacity of individual sections of the myocardium during compression of shoulder and under the influence of other factors.
ІСНУЮЧІ ЕКСПЕРИМЕНТАЛЬНІ МОДЕЛІ ВЕНОЗНОГО ТРОМБОЗУ (ОГЛЯД ЛІТЕРАТУРИ)
Authors: Boyko V. V. , Prasol V. O. , Oklei D. V. , Taraban I. A. , Boldizhar P. O.
Published: May 2017

Based on the analysis of a large volume of the literature data concerning simulation of thrombotic conditions in laboratory animals under experimental conditions, the authors discuss various models of venous thrombosis. The method proposed by S. Wessler et al. (1959) is considered to be the simplest, most readily reproducible, and least invasive one. It consists of a combination of venous hyperemia and hypercoagulation induced by the administration of an activated coagulation factor.
МОДЕЛЮВАННЯ НЕІНВАЗИВНОЇ ТЕРАПІЇ
Authors: Kosoholova L. О. , Kolomiichuk D. A. , Loshytskyi P. P. , Mynzyak D. Yu.
Published: May 2017

The article is concerned with investigations of contactless methods of therapy. It gives detailed experiments of possibility of contactless control on unicellular objects. It has estimated a minimal electromagnetic radiation that affects on unicellular objects in water.
ЗАСТОСУВАННЯ АРТЕРІАЛЬНОЇ ОСЦИЛОГРАФІЇ ДЛЯ ОЦІНКИ ЯКОСТІ АДАПТАЦІЇ СЕРЦЕВО-СУДИННОЇ СИСТЕМИ ДО ЗМІНИ ПОЛОЖЕННЯ ТІЛА (ОРТОПРОБА)
Authors: Vakulenko D. V. , Vakulenko L. O. , Kutakova O. V.
Published: May 2017

It is considered the application of oscillographic method, arterial oscillograms (at morphological, temporal and spectral methods). Indicated method makes it possible to assess the condition of specific (related to the regulation of vascular tone) and sympathoadrenal nonspecific mechanisms of adaptation on active orthostatic test. Application of oscillographic method during orthostatic test enables early detection of prenosological and premorbid conditions and assessing the reserve capacity of the organism to help doctor better plan preventive, diagnostic and therapeutic process.
Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use
Authors: Baggish Aaron L. , Weiner Rory B. , Kanayama Gen , Hudson James I. , Lu Michael T. , Hoffmann Udo , Pope Harrison G.
Published: May 2017

Background:

Millions of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associations of these drugs remain incompletely understood.

Methods:

Using a cross-sectional cohort design, we recruited 140 experienced male weightlifters 34 to 54 years of age, comprising 86 men reporting ≥2 years of cumulative lifetime AAS use and 54 nonusing men. Using transthoracic echocardiography and coronary computed tomography angiography, we assessed 3 primary outcome measures: left ventricular (LV) systolic function (left ventricular ejection fraction), LV diastolic function (early relaxation velocity), and coronary atherosclerosis (coronary artery plaque volume).

Results:

Compared with nonusers, AAS users demonstrated relatively reduced LV systolic function (mean±SD left ventricular ejection fraction = 52±11% versus 63±8%;
P
<0.001) and diastolic function (early relaxation velocity = 9.3±2.4 cm/second versus 11.1±2.0 cm/second;
P
<0.001). Users currently taking AAS at the time of evaluation (N=58) showed significantly reduced LV systolic (left ventricular ejection fraction = 49±10% versus 58±10%;
P
<0.001) and diastolic function (early relaxation velocity = 8.9±2.4 cm/second versus 10.1±2.4 cm/second;
P
=0.035) compared with users currently off-drug (N=28). In addition, AAS users demonstrated higher coronary artery plaque volume than nonusers (median [interquartile range] 3 [0, 174] mL
3
versus 0 [0, 69] mL
3
;
P
=0.012). Lifetime AAS dose was strongly associated with coronary atherosclerotic burden (increase [95% confidence interval] in rank of plaque volume for each 10-year increase in cumulative duration of AAS use: 0.60 SD units [0.16–1.03 SD units];
P
=0.008).

Conclusions:

Long-term AAS use appears to be associated with myocardial dysfunction and accelerated coronary atherosclerosis. These forms of AAS-associated adverse cardiovascular phenotypes may represent a previously underrecognized public-health problem.
Evaluating the Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drugs
Authors: Antman Elliott M.
Published: May 2017

Some drugs used to treat noncardiovascular conditions may adversely impact the cardiovascular status of individuals both with and without known cardiovascular disease. When the US Food and Drug Administration judges the potential cardiovascular safety signal to be of sufficient concern, it may require the pharmaceutical manufacturer of the drug in question to conduct a postmarketing (phase 4) randomized controlled trial (RCT). Although historically many phase 4 RCTs focused on efficacy (using a superiority design), contemporary phase 4 RCTs often are focused on safety and use a noninferiority design. The choices made by investigators during the planning stage of a postmarketing phase 4 RCT dedicated to the evaluation of cardiovascular safety can influence the ability to compare the standard and test agents. Multiple factors reflecting the conduct of a phase 4 RCT for a general medical condition may influence interpretation of a cardiovascular safety signal. The higher the rates of failure to adhere to the protocol and dropout from the study, the greater the risk of bias. Trials evaluating the cardiovascular safety of nonsteroidal anti-inflammatory drugs (NSAIDs) when used for arthritis are difficult to conduct and even more challenging to interpret. Concerns include the comparison of drug regimens that do not provide comparable analgesic efficacy and problems with adherence to the protocol and retention in the study. On the basis of phase 4 RCTs of NSAIDs to date, it appears that a comparatively low dose of celecoxib administered to low-risk subjects is associated with approximately the same cardiovascular risk as NSAIDs with less cyclooxygenase-2 inhibitory activity, but at the cost of not controlling arthritic pain as effectively.
Quantitative Value of Aldosterone‐Renin Ratio for Detection of Aldosterone‐Producing Adenoma: The Aldosterone‐Renin Ratio for Primary Aldosteronism (AQUARR) Study
Authors: Maiolino Giuseppe , Rossitto Giacomo , Bisogni Valeria , Cesari Maurizio , Seccia Teresa Maria , Plebani Mario , Rossi Gian Paolo , Semplicini Andrea , Ganzaroli Chiara , Pessina Achille Cesare , Mantero Franco , Armanini Decio , Opocher Giuseppe , Mattarello Mee‐Yung , Giacchetti Gilberta , Ronconi Vanessa , Boscaro Marco , Rossi Ermanno , Bernini Giampaolo , Moretti Angelica , Ferri Claudio , Desideri Giovambattista , Andronico Giuseppe , Rizzoni Damiano , Porteri Enzo , Palumbo Gaetana , Letizia Claudio , Caliumi Chiara , Fabris Bruno , Mannelli Massimo , Parenti Gabriele , Maccario Mauro , Ghigo Ezio , Mallamaci Francesca , Zoccali Carmine , Belfiore Anna
Published: May 2017

Background

Current guidelines recommend use of the aldosterone‐renin ratio (
ARR
) for the case detection of primary aldosteronism followed by confirmatory tests to exclude false‐positive results from further diagnostic workup. We investigated the hypothesis that this could be unnecessary in patients with a high
ARR
value if the quantitative information carried by the
ARR
is taken into due consideration.

Methods and Results

We interrogated 2 large data sets of prospectively collected patients studied with the same predefined protocol, which included the captopril challenge test. We used an unambiguous diagnosis of aldosterone‐producing adenoma as reference index. We also assessed whether the post‐captopril
ARR
and plasma aldosterone concentration fall furnished a diagnostic gain over baseline
ARR
values. We found that the false‐positive rate fell exponentially, and, conversely, the specificity increased with rising
ARR
values. At receiver operating characteristics curves and diagnostic odds ratio analysis, the high baseline
ARR
values implied very high positive likelihood ratio and diagnostic odds ratio values. The baseline and post‐captopril
ARR
showed similar diagnostic accuracy (area under the receiver operating characteristics curve) in both the exploratory and validation cohorts, indicating lack of diagnostic gain with this confirmatory test (between‐area under the curve difference, 0.005; 95%
CI
, −0.031 to 0.040;
P
=0.7 for comparison, and 0.05; 95%
CI
, −0.061 to 0.064;
P
=0.051 for comparison, respectively).

Conclusions

These results indicate that the
ARR
conveys key quantitative information that, if properly used, can simplify the diagnostic workup, resulting in saving of money and resources. This can offer the chance of diagnosis and ensuing adrenalectomy to a larger number of hypertensive patients, ultimately resulting in better control of blood pressure.
Large-scale DCMs for resting-state fMRI
Authors: Razi Adeel , Seghier Mohamed L. , Zhou Yuan , McColgan Peter , Zeidman Peter , Park Hae-Jeong , Sporns Olaf , Rees Geraint , Friston Karl J.
Published: May 2017

This paper considers the identification of large directed graphs for resting-state brain networks based on biophysical models of distributed neuronal activity, that is, effective connectivity. This identification can be contrasted with functional connectivity methods based on symmetric correlations that are ubiquitous in resting-state functional MRI (fMRI). We use spectral dynamic causal modeling (DCM) to invert large graphs comprising dozens of nodes or regions. The ensuing graphs are directed and weighted, hence providing a neurobiologically plausible characterization of connectivity in terms of excitatory and inhibitory coupling. Furthermore, we show that the use of Bayesian model reduction to discover the most likely sparse graph (or model) from a parent (e.g., fully connected) graph eschews the arbitrary thresholding often applied to large symmetric (functional connectivity) graphs. Using empirical fMRI data, we show that spectral DCM furnishes connectivity estimates on large graphs that correlate strongly with the estimates provided by stochastic DCM. Furthermore, we increase the efficiency of model inversion using functional connectivity modes to place prior constraints on effective connectivity. In other words, we use a small number of modes to finesse the potentially redundant parameterization of large DCMs. We show that spectral DCM—with functional connectivity priors—is ideally suited for directed graph theoretic analyses of resting-state fMRI. We envision that directed graphs will prove useful in understanding the psychopathology and pathophysiology of neurodegenerative and neurodevelopmental disorders. We will demonstrate the utility of large directed graphs in clinical populations in subsequent reports, using the procedures described in this paper.
Role of Joy in Farm Animal Welfare Legislation
Authors: von Gall Philipp , Gjerris Mickey
Published: May 2017

While animal welfare is commonly invoked in legal debates regarding non-human animals kept for food purposes, the concept of animal joy is rarely mentioned in such contexts. This paper analyzes the relationship between welfare and joy in the German animal protection law (gapl) and in theeudirective 98/58/ec. Based on a review of scientific and philosophical approaches towards animal welfare, joy is argued to be a part of welfare. Nevertheless, joy is ignored in the German andeulegal provisions. While there may be economic disadvantages of legally protecting animal joy, it is argued that overlooking elements of joy cannot be justified from any ethical perspective that claims to take animal welfare into consideration. In order to clarify the aims of the legal provisions, decision-makers need to define the role joy ought to play in welfare legislation.