bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling and computational investigation of cold atmospheric pressure plasma actuators
Authors: Βαφάκος Γεώργιος
Published: April 2024

Στο ερευνητικό πεδίο της αεροδυναμικής, η χειραγώγηση της ροής του αέρα πάνω σε αεροτομές, επιφάνειες ελέγχου και άλλα αεροδυναμικά στοιχεία, είναι πολύ σημαντική για τη βέλτιστη απόδοση, την αύξηση της άντωσης, τη μείωση των δυνάμεων τριβής και, τελικά, για τη διασφάλιση της ασφάλειας και της αποτελεσματικότητας των αεροσκαφών. Οι ελεγκτές πλάσματος προκαλούν ψυχρό μη θερμικό πλάσμα χρησιμοποιώντας ηλεκτρικά πεδία υψηλής τάσης σε στοχευμένες περιοχές, όπως τα σημεία αποκόλλησης του οριακού στρώματος. Το πλεονέκτημα αυτών των συσκευών βασίζεται στην απουσία κινούμενων μηχανικών μερών, στους γρήγορους χρόνους απόκρισης και στην άμεση μετατροπή ηλεκτρικής σε κινητική ενέργεια. Οι πολυπλοκότητες που συνοδεύουν μια εφαρμογή τέτοια φύσης απαιτούν μια επιστημονική προσέγγιση από διάφορους κλάδους, συμπεριλαμβανομένων επιστημονικών θεμάτων που κυμαίνονται από την κινητική του πλάσματος μέχρι τη μηχανική των ρευστών και την αριθμητική ανάλυση. Ενας από τους κύριους στόχους αυτής της εργασίας είναι να προτείνει ένα αποτελεσματικό υπολογιστικό μοντέλο τριών σταδίων για εφαρμογές Ψυχρού Πλάσματος Ατμοσφαιρικής Πίεσης, με δυνατότητα ενσωμάτωσης διαφορετικών τεχνικών επίλυσης για κάθε στάδιο. Προσομοιώσεις που εκτυλίσσονται σε πολλαπλές κλίμακες χρόνου πρέπει να εφαρμοστούν με κατάλληλο τρόπο έτσι ώστε να ξεπεραστεί το τεράστιο υπολογιστικό κόστος επίλυσης της δυναμικής του πλάσματος (μικροκλίμακα) μαζί με την επιτάχυνση του αερίου (μακροκλίμακα). Η αποτελεσματικότητα αυτού του μοντέλου έγκειται στην δυνατότητά του να επιλύει τα φαινόμενα που συμβαίνουν σε διαφορετικές χρονικές στιγμές με διαφορετικές διαδικασίες επίλυσης, επιτυγχάνοντας την μεταξύ τους αποσύνδεση. Ο αλγόριθμος τριών σταδίων εφαρμόζεται για την προσομοίωση ενός ελεγκτή πλάσματος διηλεκτρικού φράγματος εναλλασσόμενου ρεύματος, ενώ τα αποτελέσματα του επικυρώνονται έναντι πειραματικών δεδομένων. Τέλος, ένας άλλος στόχος αυτής της διατριβής είναι να εξετάσει τη λειτουργεία ενός ελεγκτή πλάσματος διηλεκτρικού φράγματος, υπό την επίδραση παλμών υψηλής τάσης διάρκειας νανοδευτερολέπτων. Ενώ οι προαναφερθέντες ελεγκτές εναλλασσόμενου ρεύματος αποδεικνύονται αποτελεσματικοί κυρίως στην περιοχή χαμηλών υποηχητικών ταχυτήτων, η λειτουργία του εν λόγω ελεγκτή υπό την επίδραση παλμών νανοδευτερόλεπτου επιτρέπει τον χειρισμό της ροής ρευστού σε ταχύτητες πιο κοντά στις ρεαλιστικές συνθήκες πτήσης.
Thymoquinone attenuates doxorubicin-induced lung damage via heat shock proteins, inflammation and endoplasmic reticulum stress
Authors: Öztürk E , Kaymak E , Akin AT , Karabulut D , Yakan B
Published: April 2024

The aim of this study is to determine possible therapeutic effects of THQ on doxorubicin induced lung damage in rats. Rats were divided into five groups (n = 8): control, THQ, olive oil, DOX (a single dose of 15 mg/kg intraperitoneally (i.p.) on seventh day of the experiment), and DOX+THQ (10 mg/kg THQ per day and 15 mg/kg DOX i.p. on seventh day). Animals were euthanized, and lung tissues were evaluated histopathologically. Caspase3, GRP78, GADD153, HSP90, HSP70, PCNA, COX2 and TNFα immunostaining were performed to determine the expression levels of these proteins among groups. TUNEL method was used for evaluation of apoptotic index. Moreover, total antioxidant status (TAS), total oxidant status (TOS) and IL6 in lung tissue were measured by ELISA assay. The DOX group had histopathological deterioration compared to the control group. There was an increase in apoptotic index, caspase 3, GRP78, GADD153, HSP90, HSP70, PCNA, COX2 and TNFα expressions in the DOX group. While TAS level of the DOX group decreased, IL6 and TOS level increased when compared with the other groups. However, there was improvement in lung tissue in DOX + THQ group compared to the DOX group. There was a decrease in apoptotic index, caspase 3, GRP78, GADD153, HSP90, HSP70, PCNA, COX2, TNFα expressions and TOS, IL6 in DOX+THQ group compared to the DOX group. We suggest that THQ can be used as a protective agent to reduce the toxic effects of DOX.
Leukogram patterns significance and prevalence for an accurate diagnosis in dogs
Authors: Moruzi RF , Morar D , Văduva C , Boboc MC , Dumitrescu E , Muselin F , Puvača N , Cristina RT
Published: April 2024

Interpretation of changes in WBC (White Blood Cell) provides valuable information for guiding the veterinarian to establish the diagnosis for a wide range of diseases. Leukocyte changes, both quantitative and qualitative, are always secondary, so the control and therapeutic success is dependent on the identification of the primary condition. The purpose of this study was the association between the magnitude of quantitative changes in leukocytes and the primary conditions in which they occurred, to facilitate a faster orientation of the diagnosis. From dogs with internal affections and based on inclusion and exclusion criteria, the survey evaluated 447 complete blood counts (CBC). In 272 of CBC analyzed, the number of leukocytes was in the physiological range (i.e. 6,000-17,000 cells × µL-1 blood), but in 131 cases, the leukocytes exceeded the upper limit, and in 44 cases, leukocytes were below the lower limit. In terms of leukocytosis, affections of the digestive system had the highest prevalence, while leucopenia, was more present in the circulatory system pathologies. The cases of leukocytosis depending on the severity were: mild (73 cases), moderate (41), and severe leukocytosis (15) and respectively, two extreme leukocytosis cases, statistically emerging: p <0.01 for IBD (inflammatory bowel disease), acute pancreatitis, ehrlichiosis, chronic babesiosis and respectively p <0.001 for acute lymphoblastic leukemia. Results revealed that infections source (devoid of parvovirosis), inflammation of the digestive tract was frequently accompanied by moderate leukocytosis, while the parvoviral caused enteritis conducted, in the early stages, to leukopenia. In bronchopneumonia, the leukocytosis was moderate, while inflammation of the anterior airways caused mild leukocytosis. Moderate leukocytosis was found also in the splenic, hepatic, and pulmonary neoplasm, and the acute lymphoblastic leukemia developed with severe leukocytosis and chronic leukemia with extreme leukocytosis.
Determination of Aflatoxin M1 levels in Turkish cheeses provided from different regions of Turkey
Authors: Ergin SÖ , Çakmak Ö , Çakmak T , Acaröz U , Yalçın H , Acaröz DA , İnce S
Published: April 2024

Hygienic quality is a very important problem in milk and dairy products. Aflatoxins are produced by moulds, and it is known that the Aflatoxin M1 type, which can be found in milk and dairy products, is a potential risk for public health. In this study, the presence of Aflatoxin M1 in white and Tulum cheese samples collected from three different provinces of Turkey (Burdur, Bursa, and Elazig) was investigated with the ELISA method. 42 white and 42 Tulum cheese samples (total 84) were analyzed, and the samples were evaluated in terms of their compliance with the limits of the Turkish Food Codex. According to the results; 34 (40.47 %) of 84 cheese samples were contaminated with Aflatoxin M1, ranging from 250 to 559 ng/kg. Fifty (59.52 %) cheese samples were found below the detection limit, meaning they are negative in terms of Aflatoxin M1 and do not pose a risk. On the other hand, 2 samples (2.38 %) were over the tolerance limit of the Turkish Food Codex. Also, the incidence of Aflatoxin M1 in white cheeses was 35.71 % and 45.23 % in Tulum cheeses. Although it is not much above the legal limit, Aflatoxin M1 contamination in cheese may reduce the food quality and adversely affect human health. Therefore, it should be treated more carefully in the production of milk and dairy products. In addition, quality feeds should be used in the feeding of dairy animals.
Proliferative and necrotizing otitis externa in a kitten: Case report with literature review
Authors: Bouza- Rapti P , Psalla D , Baka R , Farmaki R
Published: April 2024

Proliferative and necrotizing otitis externa (PNOE) is a rare dermatitis with unknown etiology affecting kittens between 2 to 6-months-old and adult cats. Its clinical signs are unique and diagnosis is based on skin histopathology. Lesions develop rapidly and in kittens may regress spontaneously. A 6.5-month-old, male, Siamese kitten was presented with chronic proliferative, erythematous and necrotic lesions covered with thick dark-brown keratinous debris on the concave aspect of both pinnae and the vertical ear canal leading to secondary otitis infection due to obstruction. Lesions were not pruritic or painful even though erosions and ulceration were seen focally. Previous treatment with commercial otic preparations was of no avail. Ear otoscopy could not be performed due to stenosis and ear canal cytology showed numerous bacteria intermingled with keratinocytes and debris. Radiography further confirmed ear canal stenosis. Histopathological examination revealed orthokeratotic and parakeratotic hyperkeratosis, epidermal hyperplasia with several apoptotic cells and neutrophilic crusts mixed with cocci. Topical treatment with 0.1% tacrolimus was prescribed twice daily and otic solutions for secondary otitis externa. Complete clinical cure was achieved two months after first admittance. This is the first report of PNOE in Greece. Topical tacrolimus appears to be an effective treatment for lesions that do not spontaneously regress.
The Therapeutic Effects of Autologous Platelet-Rich Plasma Gel on Cutaneous Wound Healing in Rescued Horses
Authors: Sajjad MT , Akbar H , Khan MA , Mushtaq MH , Bokhari SG , Hayat MA , Mustafa G
Published: April 2024

This study explored the effect of platelet-rich plasma gel on skin wound healing in rescued horses. A total of twenty horses were used and allocated into two groups: PRP-treated Group A (n=10) and ASD-treated Group B (n=10). Group A animals were treated with autologous PRP gel, while group B animals were treated with sterile saline. A full-thickness (1.5 mm2) skin wounds were selected in each horse. Histopathological examination of wound tissue in horses was performed on days 8, 40, and 60. Wound epithelialization was assessed by HE staining, and collagen re-establishment was assessed by Masson’s trichrome staining. The CAT activity and MDA concentration were assessed in blood samples on days 8, 40, and 60. All data were subjected to statistical analysis. We observed a highly significant increase (P<0.01) in re-epithelization at days 40 to 60 in the PRP wounds compared to the ASD wounds. Collagen was well organized (P<0.01) in the PRP wounds compared with the ASD wounds at day 40 to day 60. MDA concentration was significantly decreased from day 40 to day 60 (P<0.05) in the PRP wounds than the ASD wounds. CAT activity showed no difference (P>0.05) between PRP wounds and ASD wounds. In conclusion, compared to ASD wounds, PRP wounds promoted cutaneous wound healing in horses by suppressing oxidative stress levels, accelerating wound epithelialization, and generating organized tissue, interlocking collagen bundles of dermal collagen. However, ultrasonographical assessment level study is needed to further investigate the effect of PRP gel on skin wound healing in rescued horses.

Keywords: Horses, Oxidative stress, Platelet-Rich Plasma, Sterile saline, Skin Wound Healing.
Equine Herpes Virus-1. A clinician’s perspective.
Authors: Tyrnenopoulou P , Diakakis N
Published: April 2024

Equid herpesvirus type 1 (EHV-1) is a common pathogen of horses with worldwide distribution. In light of recent outbreaks reported across Europe and United States of America, the contagious nature of this disease is highlighted and re-evaluation of diagnostic procedures, treatment modalities and biosecurity protocols is imperative. This review provides an overview of the epidemiology, current treatment protocols and prognosis for EHV-1-associated syndromes, with an emphasis on the neuropathogenic strain of EHV-1.
Comparison of selected levels of serum elements / minerals in obese dogs
Authors: Cihan H , Ateş F , Karış D , Tunca M , Bozkurt NC , Parkan Yaramış Ç , Bilgiç B , Or ME
Published: April 2024

Obesity is the most common metabolic disorder defined as excessive adipose tissue accumulation in the body. Elements and minerals are crucial for biological metabolism. There have been limited studies based on the relationship between elements/minerals and obesity in dogs. The study was aimed to evaluate possible alterations of selected serum elements/minerals -copper (Cu), iron (Fe), zinc (Zn), selenium (Se), chromium (Cr), nickel (Ni), calcium (Ca), phosphorus (P), magnesium (Mg), boron (B), cobalt (Co) and aluminum (Al)- in obese dogs. The study groups were categorized as obese group (n:20) and controls (n:10) with different breeds and genders due to body condition scoring system cared under similar conditions fed with dry commercial food once daily. Serum elements/minerals in serum were analyzed by using inductively coupled plasma-optical emission spectrophotometer (ICP-OES). Obese dogs had statistically higher serum Fe levels compared with healthy controls. A positive correlation was found between serum levels of Cr-Ni; Cu-Mg; Cu-Se; Mg-Se; Mg-Ca; Mg-P; B-Co; B-Ca; Ni-Co; Co-Ca and Ca-P in obese dogs. It has been accepted that obesity is a pro-inflammatory process priorly initiating in adipose tissue. Higher serum Fe levels in obese dogs might be related with inflammation during the obesity process. Moreover, the strong correlations among other discussed elements/minerals even with no statistical alterations of serum levels in obese dogs should be elucidated with further studies. Elements and minerals might be evaluated as biomarkers for the determination of effects of obesity in dogs.
Effects of organic acid treated legume forages on in vitro degradability values
Authors: Palangi V , Macit M , Kilic U
Published: April 2024

In this context, we aimed to investigate the effects of varying levels of Fumaric Acid (Fu), Malic Acid (Ma), Formic Acid (Fo), and their combinations on in-vitro degradability parameters, organic matter digestibility (OMD), metabolizable energy (ME) and net energy lactation (NEL) of alfalfa (Medicago polymorphia), white clover (Trifolium repens) and hairy vetch (Vicia villosa). Obtained data were analyzed as a completely randomized 3×8 factorial design, with GLM using SAS 9.4. The effects of legume forages and their interacion with organic acid were significant on ME, NEL and OMD values (p<0.05, p<0.01). in such a way that fumaric acid was led to an increase NEL. All of the parameters, except ME and OMD, were affected by organic acids (p<0.01). To conclude, utilization of organic acids could increase NEL, reduce the fermentation of insoluble fraction (b) and potential extent of gas production (a+b) from ruminants and reduce rapidly soluble fraction (a) (malic acid treatment only).
The Effect of Different Feeding on Growth in Morkaraman Male Lambs
Authors: Şahinler Z , Demir Y , Gürsoy E
Published: April 2024

The object of this study is to compare the concentrated feeding under intensive conditions with the traditional two feed types applied in the Morkaraman lambs feeding in Ağrı province. By forming 3 groups having 15 heads in each with random sampling after the male lambs weaned (75th day), each group was fed with different feeding. The 1st group was subjected to traditional day and night lactation beside grazing on pasture, 2nd group was subjected to ad-libitum concentrated feed and hay- clover under intensive conditions, the 3rd group was subjected to traditional pasture grazing.  For the Morkaraman male lambs; 75th day (per feeding) and 135th day (end of feeding) average live weights are found for 1st, 2nd and 3rd groups and in general order as 21.27±0.819, 20.65±0.564, 20.57±0.824, 20.83±0.423kg and 33.43±0.727, 35.88±0.875, 26.95±1.084, 32.08±0.765 kg respectively. Regarding the 75th day live weights, the differences among three groups are similar and insignificant, regarding the 135th day live weights are similar in the 1st and 2nd groups, and the differences (p<0.01) with the 3rd group are important. Daily live weight gains on 75-90th days live weight gains are similar in the 1st and 2nd groups, the difference with the 3rd group is significant (p<0.01), regarding the 105-120th and 120-135th days the differences among three groups are found statistically significant (p<0.01). This study revealed not only the insufficiency of the lamb feeding on the low-quality pastures but also the inadequacy of the growth of the lambs sucking dams fed on the low-quality pastures and the lambs grazing on these pastures as well.  As a result, it is concluded that the concentrated feed under intensive conditions is more efficient on lamb growth; however, the feeding of the lamb and dam grazing on pasture should be supported by a supplementary feeding.

 

Keywords: Morkaraman; live weight gain; lamb growth; pasture
Social, Ethical and Regulatory implications of conducting a malaria Vaccine Efficacy trial in a human infection study in Kenya (SERVE-Kenya): A study protocol
Authors: Chi Primus Che , Olilo Winter A. , Njue Maureen , Kalama Betty , Owino Esther Awuor , Mumba Noni , Kapulu Melissa , Kamuya Dorcas ,   Members of the VAC074 Study Team
Published: April 2024

Malaria remains an important public health problem in many LMICs, including Kenya – necessitating alternative prevention and control strategies. Malaria human infection studies (HIS) – trials that involve the deliberate infection of healthy volunteers with malaria parasites to assess the efficacy of potential vaccine and drug candidates and to understand the innate and acquired protection against malaria parasites - have become an important approach to fast-track the development of a malaria vaccine. The KEMRI-Wellcome Trust Research Programme (KWTRP) otherwise known as the KEMRI Centre for Geographic Medicine Research (Coast) (KEMRI CGMRC) has developed expertise in setting up and running research on malaria HIS, with two completed and two planned in the coming months. One of the planned studies is an EDCTP-funded Phase IIb malaria vaccine efficacy trial within a HIS. While all scientific proposals at KWTRP are carefully reviewed by national and international science and ethics review bodies and are supported by a well-developed local community engagement platform, research to understand the social, ethical and regulatory issues for HIS from a grounded perspective is in early stages of development, especially in LMICs. Given the particular opportunities provided by the KWTRP’s experience in running HIS, expertise in embedded social science research and the presence of a well-established community engagement platform, we plan to conduct a social science study within the HIS-based Phase IIb malaria vaccine trial. The overall aim is to contribute to the development of locally responsive policies on the ethical conduct of malaria vaccine efficacy studies involving the use of a HIS in Kenya. Data will be collected from a range of HIS stakeholders, including HIS participants, community members, HIS research team, ethics committees, regulatory authorities and policy makers through surveys, interviews, group discussions, participatory workshops, observations and document review. This is an EDCTP-funded Career Development Fellowship project awarded to PCC.
The genome sequence of the Dracula fish, Danionella dracula (Britz, Conway & Rüber, 2009)
Authors: Rüber Lukas , Britz Ralf , Conway Kevin , Bista Iliana , McCarthy Shane , Wood Jonathan , Smith Michelle , Oliver Karen , Howe Kerstin , Durbin Richard
Published: April 2024

We present a genome assembly from an individual Danionella dracula (the Dracula fish; Chordata; Actinopterygii; Cypriniformes; Danionidae; Danioninae). The genome sequence is 665.21 megabases in span. This is a scaffold-level assembly, with a scaffold N50 of 10.29 Mb.
The genome sequence of the White-barred Knot-horn, Elegia similella (Zincken, 1818)
Authors: Hammond James ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: April 2024

We present a genome assembly from an individual male Elegia similella (the White-barred Knot-horn; Arthropoda; Insecta; Lepidoptera; Pyralidae). The genome sequence is 780.4 megabases in span. Most of the assembly is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.3 kilobases in length. Gene annotation of this assembly on Ensembl identified 18,805 protein coding genes.
The genome sequence of an ichneumonid wasp, Ophion costatus Ratzeburg, 1848
Authors: Broad Gavin R. , Fletcher Chris , Januszczak Inez ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: April 2024

We present a genome assembly from an individual male Ophion costatus (ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence is 519.4 megabases in span. Most of the assembly is scaffolded into 13 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 25.95 kilobases in length.
The genome sequence of an ichneumonid wasp, Netelia virgata (Geoffroy, 1785)
Authors: Broad Gavin R. , Fletcher Chris , Januszczak Inez ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: April 2024

We present a genome assembly from an individual male Netelia virgata (ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence is 249.7 megabases in span. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 32.68 kilobases in length.
The genome sequence of the limp eelpout, Melanostigma gelatinosum Günther, 1881
Authors: Bista Iliana , Collins Martin ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective
Published: April 2024

We present a genome assembly from a Melanostigma gelatinosum (the limp eelpout; Chordata; Actinopterygii; Perciformes; Zoarcidae). The genome sequence is 662.0 megabases in span. Most of the assembly is scaffolded into 24 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 16.83 kilobases in length.
Product Design for the Elderly Based on Human-Computer Interaction in the Era of Big Data
Authors: Liu Zhihong
Published: April 2024

Since 21st century, social aging trend has become more and more serious. It needs accurately identify the nursing needs of elderly disabled people, who are characterized by inconvenient movement and unclear speech. How to solve these problems has become a key point in the field of elderly care and medical care. In response to this problem, this research has designed a human-computer interactive gesture recognition system for elderly nursing beds in the context of big data. The recognition rate of the fusion feature + support vector machine (SVM) classifier adopted in this study is higher than 90% for each category of gesture. On the test set, this method has an average recognition rate of 96.35%, which is much higher than that of single feature + SVM classifier. While other methods’ recognition rate is lower than 90%. The recognition rate of tag c (nursing bed posture turning left) with obvious gesture feature information is as high as 99.28%, and that of tag h (nursing bed posture bedpan lowering) with weak gesture feature is 93.65%. The human-computer interaction system has well realized the recognition intention of user’s dynamic and static gestures, achieved the goal set by the research, and the interaction form is natural and reliable. In the later research, we can further realize a more comprehensive, accurate and natural human-computer interaction product design through the multi-channel joint decision-making scheme to meet the needs of the elderly.
New education for a new Russia
Authors: Privalov Nikolay , Bashmakova Natal'ya
Published: April 2024

The problem of new education for today’s Russia is of great importance due to the fact that Russia has withdrawn from the Bologna educational system and is now beginning to form a new national education system. The crisis of liberalism is a manifestation of a new systemic crisis. A new ideology of education based on patriotism, traditional culture and modern achievements of science is required. The paper proposes the main principles of the new ideology and measures of post-market reform of the education system. The subject of the study is the crisis of the Russian education system and the problem of the ideology of teaching humanities. The purpose of the work is to formulate new principles of ideology and directions for the creation of a sovereign national education system in Russia. The stated purpose required the application of a systematic approach to the research. The practical result of the implementation of the methodology of moral-religious neo-institutionalism was the release by INFRA M Publishing House of a series of educational literature - the textbook “Economic Theory. Russian economics” and related textbooks on the philosophy of economy, home economics and methodology of scientific research, united by the subtitle on the moral content of science and economics. The importance of the research is due to the fact that the results obtained open new opportunities for secondary and higher school pedagogy in the light of the creation of a sovereign national system of education in Russia. The novelty of the study lies in the formulation of principles for a new national system of education taking into account the national patriotic ideology.
Forecasting the stagnation of professional and personal development of specialists based on information stress non tolerance
Authors: Petrov Vladislav , Danilov Sergey
Published: April 2024

The article is devoted to the study of the problems of forecasting the stagnation of professional and personal development of future representatives of law enforcement agencies and doctors based on an assessment of information stress tolerance. The following methods were used: expert survey and psychological testing (questionnaire for assessing the severity of stagnation of professional and personal development; methodology for diagnosing information stress tolerance). The sample consisted of 298 people (students of the Tver State Medical University of the Ministry of Health of the Russian Federation, cadets of the Military University of the Ministry of Defense of the Russian Federation. Prince A. Nevsky and the Moscow University of the Ministry of Internal Affairs of Russia named after V.Ya. Kikot, police officers). It is shown that the stagnation of professional and personal development of specialists is largely determined by such a personal factor as information stress tolerance, which includes «Information activity», «Information skepticism», «Information illegibility», «Sensitivity to information stress», «Generalization of stressful information», «Stress regulation of behavior», «The intensity of the value conflict under stress». In the absence of trends towards stagnation in development among students of modern Russian universities, some features of its determination have been established. Thus, students (future doctors) are distinguished by an increased and sustained desire to obtain personally significant information and information sensitivity. At the same time, under the influence of intensive informational and psychological influence, both students and cadets do not have a revision of interests, motives and goals of life, i.e. students «live an ordinary life». Linear regression models for assessing «Stagnation of professional and personal development», «Loss of motivation for self-realization», «Awareness of stagnation in work» based on particular indicators of information stress non tolerance of specialists are proposed and tested. The approach makes it possible to improve the methods of psychological prevention and support of specialists in terms of overcoming stagnation phenomena at the personal level, as well as countering negative informational and psychological influence.
Study of university students' attitudes towards the use of art therapy
Authors: Kutyavina Anna , Ryzhov Yuriy
Published: April 2024

The article presents the results of an empirical study, the purpose of which is to study the attitude of university students to the use of art therapy. It was assumed that students have insufficient knowledge about art therapy, and the study of art therapy courses by future psychologists and teachers is important for the development of their professional competencies. A questionnaire was developed that included eight questions characterizing students’ knowledge of art therapy (general understanding and familiarity with it, its definition, applicability and effectiveness, types, benefits for professional and psychological tasks). A survey of 42 students of the Faculty of Psychology and Social Pedagogy of the Taganrog Institute named after A.P. Chekhov (branch) of the Russian State Economic University (RINH) was conducted, as well as 39 students of technical areas of the Southern Federal University in Taganrog. The main result of the study was that students’ knowledge of art therapy was quite poor (especially students of technical specialties). At the same time, a significant part of students are interested in art therapy and consider it useful for professional development and psychological health. The results obtained can be used in the development of university academic disciplines in art therapy. A conclusion is made about the desirability of including some art therapy methods in the training program (primarily psychological and pedagogical areas), which will improve the quality of training of future specialists.
Gamification in education as a factor in the formation of relevant professional competencies
Authors: Antonovskiy Aleksandr , Zhuykova Sofiya
Published: April 2024

The article considers aspects of the use of gamification in education as a factor in the formation of professional competencies. In the context of learning, gamification is understood as a certain technology associated with the introduction of game components into the educational process based on the use of algorithms that were previously used in various computer gaming programs. Such trends in educational practice, in the context of the use of gamification, as the systematization of practical experience in the use of gamification and the development of its theoretical and methodological foundations are highlighted; the focus on achieving certain educational results is the formation of professional competencies within the framework of educational activities; the use of gamification in teaching various disciplines of the curriculum: foreign languages, engineering specialties, in inclusive educational practice, in management, in marketing, etc. In the context of digital transformation of education, the implementation of gamification forms the necessary motivation for educational activities, expands the boundaries of professional and personal development for all subjects of educational activity. Gamification allows you to implement various psychological and pedagogical techniques and methods to achieve learning goals, including the differentiation of strategic and tactical goals when completing course assignments, maintaining the necessary level of attention and concentration of students, combining various options for the complexity of tasks performed and on this basis identifying the abilities of participants to solve these tasks in a timely manner, modeling and implementing various game situations for the formation and development of certain professional competencies, etc. In the context of the development of the digital economy, globalization and informatization of educational activities, gamification optimally complements the already existing traditional training, with an emphasis on the use of game techniques in education, the involvement of gamification participants in solving collective tasks, achieving personal and group goals when completing the course in the form of a game, revealing their abilities precisely within the framework of team tasks and, thus, forming the necessary relevant professional competencies within the framework of educational activities.
Comparative analysis of the development of highly qualified personnel: transition of the Federal State Educational Standard to the Federal State Educational Standard
Authors: Kuznetsov Maxim
Published: April 2024

Strategic features of the formation and optimization of highly qualified personnel, in the context of a rapidly developing state program of adjunct/postgraduate studies, the transition from Federal state educational standards to Federal state requirements is of particular importance. The transition to federal state requirements is aimed at increasing the quality of the formation of research competencies of adjuncts/graduate students in educational institutions of higher education. The existing trends are aimed at improving the formation of professional skills of young professionals. At the same time, significant changes in the return to pre-existing federal state requirements cover aspects of regulating the scientific activities of scientific, pedagogical and scientific personnel and scientific supervisors fixed on the basis of internal regulations. To which the relevant requirements of the management of the associate/graduate student were also fixed. Optimization of the direction of training scientific, pedagogical and scientific personnel in accordance with federal state requirements fix certain guidelines for the independent functioning of an educational organization, which gives it a large list of freedom of action aimed at training adjuncts /graduate students.

The purpose of the article is to analyze and comparatively summarize normative legal acts aimed at improving the training of adjuncts/graduate students in the field of science and higher education.
PEDAGOGICAL ANALYSIS OF PREVENTION OF ASOCIAL BEHAVIOR IN MINORS IN HISTORICAL RETROSPECTIVE
Authors: Zyablova Anastasiya
Published: April 2024

Antisocial behavior of minors is a problem that is projected into modern times, but its underlying causes are reflected in every historical period, starting from pre-revolutionary. The difficult living conditions of street and neglected children and teenagers force them to take extreme measures, beg, and commit crimes. It is historical experience that can explain the pedagogical aspects of the prevention

of antisocial behavior of minors, since in each era appropriate content and tools were proposed, based on pedagogical approaches that were relevant for a particular time, which are important grounds for the development of preventive measures in relation to the social and pedagogical phenomenon of “trouble.” Historical analysis helps to identify both ineffective methods of education and successful practices, which will subsequently allow you to use successful experience and not make the mistakes of the past. The article examines the key administrative decisions and pedagogical methods that were in Russia in different historical periods, with an emphasis on the pre-revolutionary and Soviet periods. An analysis of historical sources, pedagogical literature, and legal documents

is provided in order to study measures to combat and prevent antisocial behavior among children and adolescents. The hypothesis of this study is the possibility of using the practical experience of past historical periods in modern times.
Implementation of scientific and educational reproaches to develop critical thinking of region experts-to be
Authors: Hlyzova Natal'ya
Published: April 2024

This article deals with the issues to develop critical thinking in teaching region studies. It gives the approach to study the region through a correct evaluation of the information about it. It shows the modern need to study the region through the work with information, to select it, check, analyze, evaluate, make a conclusion. It is an urgent vector of the modern education system to prepare region experts with a high level of critical thinking, who are able to operate with foreign-language media texts, alternative data sources, who know the ways how media work, who can deal with popular types of fakes. The author considers critical thinking as a necessary quality of personality and one of the main skills of a region expert. It requires developing systematically and purposefully in the pedagogical process. It uses methods of theoretical and practical analyses. The research of scientific and educational approaches to develop critical thinking reveals an optimal way to implement them in the preparation of region experts. It gives the experience of testing and its results confirming the hypothesis and clearly testifying to the effectiveness of the identified scientific and educational approaches. The author concludes that the identified scientific and educational approaches contribute to the targeted development of critical thinking in region studies, increase the effectiveness of a complex regional analysis, can be implemented in any compulsory discipline of region studies in various types of educational institutions.
The role of diabetes on the development of abdominal aortic aneurysms (AAA)
Authors: Siwek Michal , Beutler Jacek , Beutler Katarzyna , Lewandowski Jędrzej
Published: April 2024

An abdominal aortic aneurysm (AAA) is a pathological local dilatation of the abdominal aorta that may develop from a variety of causes. With a 80% mortality rate, it is mainly linked to male gender, age above 65 years, smoking, and a family history of AAA. Ultrasonography is an effective method for screening males who are 65 or older for AAA. Endovascular aneurysm repair (EVAR) procedure reduces 30-day operative mortality and hospital stay, becoming a global standard. Both open and endovascular surgery aim to cut off the aneurysm's circulation, preventing it from rupturing. Diabetes mellitus (DM) may provide protection against regrowth and the need for additional intervention after endovascular AAA repair, thereby limiting the enlargement and rupture of AAAs. Hyperglycemia thickens the aortic walls and reduces wall stress in diabetic patients' abdominal aortas. It stabilizes collagen structure and promotes the synthesis of collagen type IV. Anti-diabetic drugs like metformin, thiazolidinedione, and dipeptidyl peptidase 4 inhibitors (DPP-4i) have been shown in both animal and human studies to protect against aortic aneurysms. In a dose-response pattern, these antidiabetic drugs may lower the prevalence, incidence, and enlargement rate of AAA.
Hereditary Hemorrhagic Telangiectasia - a literature review
Authors: Stodolak Marcel , Krużel Aleksandra , Kłos Kamil , Sajdak Piotr , Tomasik Justyna , Dębik Marika , Szydłowski Łukasz , Żurowska Klaudia , Ziajor Seweryn , Bednarski Artur , Turski Mikołaj
Published: April 2024

Introduction and purpose: Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare and complex vascular disorder characterized by abnormal blood vessel formation. It can present significant challenges in diagnosis and management, as it is currently estimated up to 90% of those affected are never diagnosed. Despite its rarity, HHT can carry substantial implications for patients and their families, at times requiring comprehensive medical care and support. This paper aims to provide an in-depth exploration of HHT, encompassing its epidemiology, genetics, clinical manifestations, diagnostic approaches, and current management strategies. Moreover, we hope to point out possible areas in need of future research.

Description of the state knowledge: HHT is an autosomal dominant genetic disorder that affects 1 in 5-10,000 people. Its most prominent symptoms include telangiectasia of skin and mucous membranes, recurrent epistaxis, gastrointestinal bleeding and arteriovenous malformations in vital organs. In the vast majority of cases, it is caused by a mutation in one of the following genes: ENG, ACVRL1, SMAD4; however, mutations in other genes have been described to cause a similar or much the same constellation of symptoms. Treatment options are focused on managing symptoms and improving quality of life, but possible new treatment options are being researched that could change the landscape of HHT management.

Summary: HHT is a severely underdiagnosed disease that has seen a surge of researchers’ interest in recent years. We firmly believe that, combined with plummeting costs of genetic testing and possible new treatment options, means that HHT will become increasingly important in physicians’ everyday practice.
Ketogenic diet for ovarian disorders - promising nutritional approach in polycystic ovarian syndrome and ovarian cancer
Authors: Wojtuś Magda , Tomaszuk Sebastian , Wąsik Karolina
Published: April 2024

Introduction and purpose:

Polycystic ovary syndrome (PCOS) is the most common endocrine disease in the female reproductive age. As treatment guidelines include lifestyle changes, various diet types are being evaluated in terms of efficacy among them ketogenic diet (KD) which was also assessed in terms of its influence on another ovarian related disease - ovarian cancer. The aim of this paper is an analysis of the available scientific data in respect of the role of the KD as a part of the therapy of ovarian related disorders. The search was conducted using PubMed and Google Scholarship databases.

Brief description of the state of knowledge:

Ketogenic diet demonstrates favorable effects in the hormonal profile of  PCOS-affected women. It was also noticed that its administration results in the reduction of BMI and the improvement in glycemic parameters. Most of the research was conducted by linking the ketogenic diet with the caloric restriction. In the matter of ovarian cancer the results are unclear; some of the research states the improvement of the quality of life of the participants, but there is some alarming data of the possible role of KD in enhancing the tumor growth.

Conclusions:

Ketogenic diet merits further research as a possible factor in the treatment of PCOS as foregoing results are pointing to its efficacy. Nevertheless, still more data is needed to determine its role as studies were conducted within a short period of time with relatively small research groups. There are also other limitations such as the lack of comparison with other dietary patterns with the caloric deficit which makes it difficult to deduce the main profitable factor. When it comes to ovarian cancer the results of the current data are also unclear and unambiguous with the possible negative effects.
Treatment with Digoxin – is it a clinical challenge? A Retrospective Analysis of Hospitalizations due to Digoxin intoxication
Authors: Wais Marcin , Zając Marlena , Gruca Dariusz , Zalewski Paweł , Wróblewski Wiktor , Raabe Adam , Tchórz Michał
Published: April 2024

Introduction and purpose: Digoxin, a cardiac glycoside derived from Digitalis lanata, has stood as a cornerstone in the treatment of various cardiovascular disorders for centuries. This study aims to delve into the demographic aspects, clinical characteristics, and outcomes associated with Digoxin poisoning. By drawing upon a dataset involving 22 patients hospitalized for Digoxin intoxication at the Clinical Department of Toxicology and Cardiology in Lublin, Poland, spanning from April 2014 to December 2023, our investigation seeks to provide an understanding of this issue.Brief description of the state of knowledge: Despite the efficacy of Digoxin, the potential risk of intoxication, especially in the elderly, necessitate a comprehensive examination. Age-related changes, such as declining renal function,  electrolyte imbalances, comorbidities and polypharmacy affect how drugs like Digoxin work. The symptoms of Digoxin poisoning can manifest in various organ systems such as cardiovascular, gastrointestinal, nervous system, highlighting the importance of prompt recognition to seek medical attention.Methods and results: In our study, we analyzed data from 22 patients hospitalized due to Digoxin intoxication, focusing on demographic aspects, clinical characteristics and outcomes. The cases of Digoxin poisoning were categorized according to several factors, including the quantity and nature of substances consumed, the cause of intoxication, gender, age brackets, health conditions, peak serum Digoxin levels, length and outcomes of hospitalization.Conclusions: Our study provides insights into the characteristics and outcomes of patients hospitalized due to Digoxin intoxication. The findings underscore the association of Digoxin poisoning, and emphasize the importance of monitoring serum levels to prevent adverse outcomes. As Digoxin continues to be relevant in treating cardiovascular conditions, our study calls for careful management and monitoring.
Bergamot Polyphenols: Promising Agents for Health and Wellness
Authors: Gruca Dariusz , Wais Marcin , Zając Marlena , Zalewski Paweł , Wróblewski Wiktor , Raabe Adam
Published: April 2024

Introduction and purpose: Citrus bergamia, commonly known as bergamot, is a unique plant native to the Calabria region in Italy, prized for its fragrant fruits and versatile applications. Historically utilized for extracting essential oil, bergamot has garnered attention for its therapeutic properties, particularly its Bergamot-derived Polyphenolic Fraction (BPF), which exhibits lipid-lowering, antioxidant, and anti-inflammatory effects. This paper aims to provide a comprehensive summary of existing research on the therapeutic potential of BPF in humans.Brief description of the state of knowledge: BPF has shown promise in supporting wound healing, alleviating neuropathic pain, and exhibiting antimicrobial properties. Research highlights BPF's role in modulating lipid metabolism, particularly in reducing LDL cholesterol and triglycerides while increasing HDL cholesterol levels. Additionally, BPF demonstrates anti-inflammatory effects, accelerating the recovery process in conditions such as non-alcoholic steatohepatitis (NASH) and potentially influencing pathways involved in cancer cell proliferation and apoptosis. Further studies explore BPF's impact on bone metabolism, erectile dysfunction, and its potential in dermatological applications, particularly in counteracting photoaging.Conclusions: While existing studies underscore the promising therapeutic effects of BPF in various medical domains, further research is warranted to establish its efficacy and safety for broader clinical use. Continued investigation on a larger scale holds the potential to develop BPF as a valuable physiotherapeutic strategy across diverse medical fields.