bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple Methyl-CpG Configurations Define Cell Identity Through Gene Expression Regulation.
Authors: Improda Teresa , Morgera Valentina , Vitale Maria , Passaro Fabiana , Feola Antonia , Porcellini Antonio , Cuomo Mariella , Pezone Antonio
Published: May 2023

Cell identity is determined by chromatin structure and the profiles of gene expression, which are dependent on chromatin accessibility and DNA methylation of regions critical for gene expres-sions, such as enhancers and promoters. These epigenetic modifications are required for mamma-lian development and are essential for the establishment and the maintenance of the cellular iden-tity. DNA methylation was once thought to be a permanent repressive epigenetic mark, but sys-tematic analysis in various genomic contexts reveals a more dynamic regulation than previously thought. In fact, both active DNA methylation and demethylation occur during cell fate commit-ment and terminal differentiation. To link methylation signatures of specific genes to their ex-pression profiles, we have determined the methyl-CpG configurations of the promoters of five genes switched on and off during murine postnatal brain differentiation by bisulfite-targeted se-quencing. We report here the structure of significant, dynamic and stable methyl-CpG profiles as-sociated with silencing or activation of expression of genes during brain postnatal differentiation. Strikingly, these methylation cores mark different mouse brain areas and cell types derived from the same areas during postnatal differentiation.
Antioxidant Effects of Catechins (EGCG), Andrographolide and Curcuminoids Compounds for Skin Protection, Cosmetics and Dermatological Uses: An Update
Authors: Messire Gatien , Serreau Raphaël , Berteina-Raboin Sabine
Published: May 2023

Here we have chosen to highlight the main natural molecules extracted from camellia sinensis, andrographis paniculata and curcuma longa that may possess antioxidant activities of interest for skin protection. The molecules involved, in the antioxidant process are respectively catechins derivatives, in particular EGCG, andrographolide and its derivatives as well as various curcuminoids. These plants are generally used as beverages for camellia sinensis (tea tree), as dietary supplements or as spices. The molecules they contain are known for their diverse therapeutic activities, including anti-inflammatory, antimicrobial, anti-cancer, antidiabetic and dermatological treatment. Their common antioxidant activities and therapeutic applications are widely documented, but their use in cosmetic is more recent. In this review, we will endeavor to compile the cosmetic uses of these natural molecules of interest, the various structural modulations reported, with the aim of improving their bioavailability as well as establishing their different mechanisms of action.
Application of Classification and Stage Evacuation in Station-city Integration Building: A Case Study of Chongqing East Station
Authors: Ding Dan , Wei Wenbin , Yang Longlong
Published: May 2023

In response to the fire protection design challenges faced by the integrated station-city engineering under the new model of station-city fusion, such as large building volume, diverse traffic types, functional integration, spatial complexity, and inapplicable standards, this paper selects Chongqing East Station as a typical engineering case. The fire safety engineering methods and performance-based fire protection design ideas were used. The paper summarized the fire protection difficulties, such as multifunctional combination construction, large fire protection distance, large fire protection zoning area, long evacuation distance, and design of evacuation (quasi) safety zones. Combining with the actual situation of the engineering, this paper analyzed the basic technical measures taken to address these design challenges. By adopting the method of fire safety engineering, the safety of the design scheme is verified, which can provide a solution approach for the current fire protection design challenges in the integrated station-city engineering.
Stereo SLAM in Dynamic Environments using Semantic Segmentation
Authors: Ai Yongbao , Sun Qianchong , Xi Zhipeng , Li Na , Dong Jianmeng , Wang Xiang
Published: May 2023

As we all know, many more dynamic objects appear almost continuously in real world, which are immensely able to impair the performance of the majority of vision-based SLAM systems that are based on the static-world assumption. In order to improve the robustness and accuracy of visual SLAM in the high dynamic environment, a real-time and robust stereo SLAM system for dynamic scenes was proposed. To weaken influences of dynamic content, the moving object detection method was put forward in our visual odometry, then the semantic segmentation network was combined into our stereo SLAM to extract pixel-level contours of dynamic objects. Then influences of dynamic objects were extremely weaken and the performance of our system was increased markedly in dynamic, complex and crowed city spaces. Experiment with both on KITTI Odometry dataset and in a real-life scene, the results show that our method can dramatically decrease the tracking error or drift, improve the robustness and stability of our stereo SLAM in high dynamic outdoor scenarios.
Biosensing for Autoimmune Chronic Disease: A Review
Authors: Golfinopoulou Rebecca , Kintzios Spyridon
Published: May 2023

Although relatively rare, affecting 8% of the general population, autoimmune disorders are causative linked with chronic diseases and morbidity. Control of the course of the disease is closely dependent on the ability to monitor its onset as well as response to treatment. In the present report, we review the progress in the development of biosensor-based approaches and related tools for the Point-of-Care diagnosis and monitoring of biomarkers related to several autoimmune diseases, such as Myasthenia Gravis, Rheumatoid Arthritis, Multiple Sclerosis, Systemic Erythematosus Lupus, Crohn’s Disease, Diabetes Mellitus, Behcet’s disease, Psoriasis and Celiac Disease. Various biosensing technologies are discussed, including electrochemical, optical and mechanical ones, along with the use of advanced nanomaterials and immobilization techniques for the biorecognition elements. The need for innovative devices with unique features of rapid, low-cost, real-time detection is considered in the context of preventing permanent organ and tissue damage from chronic autoimmune diseases.
The Global Burden of Community-Acquired Pneumonia, Encompassing Invasive Pneumococcal Disease and the Prevalence of Its Associated Cardiovascular Events, With a Focus on Pneumolysin and Macrolide Antibiotics in Pathogenesis and Therapy
Authors: Anderson Ronald , Feldman Charles
Published: May 2023

Despite innovative advances in anti-infective therapies and vaccine development technologies, community-acquired pneumonia (CAP) remains the most persistent cause of infection-related mortality globally. Confronting the ongoing threat posed by Streptococcus pneumoniae (the pneumococcus), the most common bacterial cause of CAP, particularly to the non-immune elderly, remains challenging due to the propensity of the elderly to develop invasive pneumococcal disease (IPD), together with the predilection of the pathogen for the heart. The resultant development of often fatal cardiovascular events (CVEs), particularly during the first seven days of acute infection, is now recognized as a relatively common complication of IPD. The current review represents an update on the prevalence and types of CVEs associated with acute bacterial CAP, particularly IPD. In addition, it is focused on recent insights into the involvement of the pneumococcal pore-forming toxin, pneumolysin (Ply), in subverting host immune defenses, particularly the protective functions of the alveolar macrophage during early-stage disease. This, in turn, enables extra-pulmonary dissemination of the pathogen, leading to cardiac invasion, cardiotoxicity and myocardial dysfunction. The review concludes with an overview of the current status of macrolide antibiotics in the treatment of bacterial CAP in general, as well as severe pneumococcal CAP, including a consideration of the mechanisms by which these agents inhibit the production of Ply by macrolide-resistant strains of the pathogen.
Cyanoacrylate in Colorectal Surgery: Is It Safe?
Authors: D'Amore Anna , Anoldo Pietro , Manigrasso Michele , Aprea Giovanni , De Palma Giovanni Domenico , Milone Marco
Published: May 2023

Anastomotic leakage (AL) after the creation of a gastrointestinal (GI) anastomosis remains an important complication in GI surgery. From its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide “prophylaxis” against AL. However although in surgical practice it is increasingly used, evidences on humans are still lacking. The aim of this study is to evaluate in humans the safety of CA to seal colorectal anastomosis. All consecutive patients from Jannuary 2022 through December 2022 who underwent minimally invasive colorectal surgery were retrospectively analysed from a prospectively maintained database. Inclusion criteria were histological diagnosis of cancer, totally minimally invasive procedure and absence of intraoperative complications. 103 patients were included in the study, N-butyl cyanoacrylate with metacryloxisulfolane (Glubran 2 ®) was used to seal colorectal anastomosis, no adverse reactions to CA or postoperative complications related to inflammation and adhesions occurred, only one case of AL (0.9%) was recorded. We can consider this study an important proof of concept on safety of CA to seal colorectal anastomosis. It opens the possibility to start performing prospective and comparative studies in humans to evaluate effectiveness of CA in preventing colorectal AL.
Adlercreutzia equolifaciens Is an Anti-inflammatory Commensal Bacterium with Decreased Abundance in Gut Microbiota of Patients with Metabolic Liver Disease
Authors: Plaza-Onate Florian , Chamignon Célia , Burz Sebastian , Lapaque Nicolas , Monnoye Magali , Philippe Catherine , Bredel Maxime , Chêne Laurent , Farin William , Paillarse Jean-Michel , Boursier Jérome , Ratziu Vlad , Mousset Pierre-Yves , Doré Joël , Gérard Philippe , Blottière Hervé M.
Published: May 2023

Non-alcoholic fatty liver disease (NAFLD) affects about 20–40% of the adult population in high-income countries and is now a leading indication for liver transplantation and can drive to hepatocellular carcinoma. The link between gut microbiota dysbiosis and NAFLD is now clearly established. Through analyses of the gut microbiota with shotgun metagenomics, we observed that compared to healthy controls, Adlercreutzia equolifaciens is depleted in patients with liver diseases such as NAFLD. Its abundance also decreases as the disease progresses and eventually disappears in the last stages indicating a strong association with disease severity. Moreover, we show that A. equolifaciens possesses anti-inflammatory properties, both in vitro and in vivo in a humanized mouse model of NAFLD. Therefore, our results demonstrate a link between NAFLD and the severity of liver disease and the presence of A. equolifaciens and its anti-inflammatory actions. Counterbalancing dysbiosis with this bacterium may be a promising live biotherapeutic strategy of liver diseases..
Seasonal Urban Heat Island Observation from Remote Sensing by Using Google Earth Engine Over New Capital (IKN) East Kalimantan, Indonesia
Authors: Tursilowati Laras , Sunarya Rachmat , Muzirwan Muzirwan , Susanti Indah , Rahayu Soni Aulia , Kartika Tatik , Suhermat Mamat , Aminuddin Jamrud , Arif Nursida
Published: May 2023

The relocation of the Indonesian capital from Jakarta to Ibu Kota Nusantara (IKN) East Kalimantan IKN will affect several sectors. The change in land use from vegetated to developed land will lead to local climate changes, including the emergence of the urban heat island (UHI) phenomenon, which is reflected in a higher land surface temperature (LST) than the surrounding area. In this study, an analysis of UHI propagation was conducted on a seasonal (DJF, MAM, JJA, and SON), with 5 yearly periods from 2001 to 2020, study area in IKN and its buffer cities (Balikpapan, Samarinda, and Bontang). Terra-MODIS satellite data are processed using Google Earth Engine (GEE) platform and output is done using GrADS. UHI (high LST) is found in urban areas/buffer cities both spatially and temporally in every season, while UHI has not yet occurred in IKN (low LST) and suburban, rural, hilly areas, vegetated areas, and water bodies (lakes, rivers). The cross-sectional latitudinal and longitudinal analysis showed that the LST DJF2015-2020 from highest to lowest temperature are in Balikpapan City (36.84 OC), Samarinda City (36.13 OC), Bontang City (32.3 OC); and IKN zero point (28.82 OC). The UHI propagation was observed in 2001-2005, 2006-2010, 2011-2015, and most during 2016-2020. Seasonally, the UHI was most pronounced in the SON season, while on lowest UHI was observed in the MAM season.
Sustainable Mining in Cameroon
Authors: Zang Lucien Antoine , Higueras Pablo
Published: May 2023

Considering the differences between the European and African continents concerning the management of the mining production sector, we decided to carry out this study with the main objective of demonstrating that, in Africa, mining can positively change the quality of life of the populations where it develops and, at the same time, it is possible to respect the environment, which is our main wealth. To achieve these objectives, it is necessary to present the mining activity of the continent, emphasizing both the negative aspects and its strong points. The most important thing is to make a good diagnosis of the situation, which will allow us to cure our "patient", that is, African mining production.
Research on the Device of Micro Droplet PCR in Microfluidic Chip Based on Constant Pressure Regulation
Authors: Duanmu Luyang , Yu Yuanhua , Meng Xiangkai
Published: May 2023

The device and method in accordance with the constant pressure regulation of micro droplet PCR in microfluidic chips are developed to explore the optimization way for the micro droplet movement, fragmentation, and bubble generation in microfluidic chips in existing digital PCR technology. In the developed device, an air source device is adopted to regulate the pressure in the chip, such that micro droplet generation and PCR amplification without bubbles can be achieved. In 3 min, the sample in 20ul will be distributed into nearly 50,000 water-in-oil droplets exhibiting a diameter of about 87μm, and the micro droplet will be subjected to a close arrangement in the chip without air bubbles. The device and chip are adopted to quantitatively detect the human gene . As indicated by the experimental results, a good linear relationship exists between detection signal and DNA concentration ranging from 101~ 105 copies /μL (R2=0.999). The micro droplet PCR devices based on constant pressure regulation chips exhibit a wide variety of advantages (e.g., achieving high pollution resistance, micro droplet fragmentation and integration avoidance, reducing human interference, and standardizing results). Thus, micro droplet PCR devices based on constant pressure regulation chips have promising applications in nucleic acid quantification.
TLR4 Overexpression Aggravates Bacterial Lipopolysaccharide-Induced Apoptosis via Excessive Autophagy and Nf-κB/Mapk Signaling in Transgenic Mammal Models
Authors: Wang Sutian , Zhang Kunli , Song Xuting , Huang Qiuyan , Lin Sen , Deng Shoulong , Qi Meiyu , Yang Yecheng , Lu Qi , Zhao Duowei , Meng Fanming , Li Jianhao , Lian Zhengxing , Luo Chenglong , Yao Yuchang
Published: May 2023

Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and induces innate immune responses, autophagy and cell death, which have major impacts on the body physiological homeostasis. However, the role of TLR4 in bacterial LPS-induced autophagy and apoptosis in large mammals remains unknown, which are closer to humans than rodents in many physiological characteristics. So far, few reports focus on the relationship between TLR, autophagy and apoptosis in large mammal levels. We urgently need more tools to further explore their crosstalk. Here, we generated a TLR4-enriched mammal model (sheep) and found that a high-dose LPS treatment blocked autophagic degradation and caused strong innate immune responses and severe apoptosis in PBMCs of transgenic offspring. Excessive accumulation of autophagosomes/autolysosomes might contribute to LPS-induced apoptosis in PBMCs of transgenic animals. Further study demonstrated that inhibiting TLR4 downstream NF-κB or p38 MAPK signaling pathways reversed the LPS-induced autophagy activity and apoptosis. These results indicate that the elevated TLR4 aggravates LPS-induced PBMCs apoptosis by leading to lysosomal dysfunction and impaired autophagic flux, which is associated with TLR4 downstream NF-κB and MAPK signaling pathways. This study provides a novel TLR4-enriched mammal model to study its potential effects on autophagy activity, inflammation, oxidative stress and cell death. These findings also enriched the biological functions of TLR4 and provided powerful evidence for bacterial infection.
Analysis of Isotropic Rectangular Kirchhoff Plates with Two Opposite Edges Clamped Using the Flexibility Method and a Modified Lévy Solution
Authors: Fogang Valentin
Published: May 2023

The aim of this paper is the analysis of isotropic rectangular Kirchhoff plates with two opposite edges clamped and the other edges having various support conditions. Rectangular Kirchhoff plates with two opposite edges simply supported are usually analyzed using the simple trigonometric series of Lévy or the double trigonometric series of Navier, while the loads are expanded in Fourier series. In this paper the flexibility method (or force method) of the linear beam theory was applied whereby the unknowns were the bending moments along the opposite edges; in this regard, the primary system was the plate simply supported along the above-mentioned opposite edges and subjected to the external loads, system solved using the Lévy solution, and the redundant system was the plate simply supported along the opposite edges and subjected to bending moments along those edges. In the redundant system, a modified Lévy solution was introduced to account for the edge moments. The compatibility equations (vanishing of the slopes at selected positions of the opposite edges) were set to determine the unknowns and so the efforts in the plate. The results obtained were in good agreement with the exact results.
Effects of Adjuvants on the Effectiveness and Rainfastness of Rimsulfuron in Potato
Authors: Alebrahim Mohammad Taghi , Samadi Kalkhoran Elham , Majd Roghayyeh , Khatami Seyedeh Asieh , Tseng Te-Ming Paul , Travlos Ilias
Published: May 2023

Abstract: Using adjuvants to optimize and increase the efficacy of herbicides is an acceptable manner to reduce herbicides undesirable impact on the environment in sustainable agriculture. In this study, it was demonstrated that the application of 0.1% of the non-ionic surfactant (NIS, Contact) and 0.5 L ha-1 of a crop oil concentrate (COC, Renol) did not improve the efficacy of rimsulfuron on Amaranthus retroflexus. In contrast, the same treatments enhanced performance and rainfastnes of rimsulfuron in Chenopodium album in pot expriments. Increasing non-ionic surfactant concentration to 1 L ha-1 increased rimsulfuron performance around 11-fold for Amaranthus retroflexus compared to around 3-fold for Chenopodium album. The same treatment, also reduced the rainfastness of rimsulfuron on Amaranthus retroflexus while improving the rainfastness of rimsulfuron on Chenopodium album. Measured ED50 and ED90 values of rimsulfuron indicated that the addition of the 0.2 L ha-1 of NIS improved the recommended (60 g ai. ha-1) and the reduced (30 g ai. ha-1) of rimsulfurom in field. The highest potato yield measured (60 tons per ha) when 60 g ai. ha-1 rimsulfuron was applied at three stages (S1, S4, and S7) without using a NIS; not significant differences were measured when the same dose of rimsulfuron was applied at the three (S1, S4, and S7) and two (S1, S4) stages with NIS.
Longitudinal Analysis of Social Isolation and Cognitive Functioning Among Hispanic Older Adults with Sensory Impairments
Authors: Trujillo Tanner Corinna , Yorgason Jeremy , White Avalon , Armstrong Chresten , Cash Antonia , Case Rebekah , Ehrlich Joshua R.
Published: May 2023

Objectives: Understanding the intersection of age, ethnicity, and disability will become increasingly important as the global population ages and becomes more diverse. By 2060, Hispanics will comprise 28% of the U.S. population. This study examines critical associations between sensory impairment, social isolation, and cognitive functioning among Hispanic older adults.
Methods: Our sample consisted of 557 Hispanic older adults that participated in Rounds 1-3 or Rounds 5-7 of the National Health and Aging Trends Study. Longitudinal mediation models across a three-year span were estimated using Mplus with vision, hearing, and dual sensory impairment predicting cognitive functioning directly and indirectly through social isolation.
Results: Findings indicated that cognitive functioning was concurrently and, in certain cases, longitudinally predicted by vision and dual sensory impairment, and by social isolation. Contrary to expectations, vision and hearing impairment were not predictive of social isolation. Dual sensory impairment was associated with social isolation, yet no significant indirect associations were found for sensory impairments predicting cognitive functioning through social isolation.
Discussion: The finding that social isolation did not mediate the relationship between sensory impairment and cognitive decline among Hispanic older adults in the U.S. is contrary to findings from other studies that were not specifically focused on this population. This finding may be evidence that culturally motivated family support and intergenerational living buffer the impact of sensory impairments in later life. Findings suggest that Hispanic older adults experiencing dual sensory impairments may benefit from interventions that foster social support and include family members.
Volatile Short-chain Aliphatic Aldehydes Act as Taste Modulators through the Orally Expressed Calcium-sensing Receptor CaSR
Authors: Kitajima Seiji , Maruyama Yutaka , Kuroda Motonaka
Published: May 2023

Aldehydes are natural volatile aroma compounds generated by the Maillard reaction of sugars and amino acids in food and affect the flavor of food. They have been reported to exert taste-modifying effects, such as increases in taste intensity at concentrations below the odor detection threshold. The present study examined the taste-enhancing effects of short-chain aliphatic aldehydes, such as isovaleraldehyde (IVAH) and 2-methylbutyraldehyde, attempted to identify the taste receptors involved. The results obtained revealed that IVAH enhanced the taste intensity of taste solutions even under the condition of olfactory deprivation by a noseclip. Furthermore, IVAH activated the calcium-sensing receptor CaSR in vitro. Receptor assays on aldehyde analogues showed that C3-C6 aliphatic aldehydes and methional, a C4 sulfur aldehyde, activated CaSR. These aldehydes functioned as a positive allosteric modulator for CaSR. The relationship between the activation of CaSR and taste-modifying effects was investigated by a sensory evaluation. Taste-modifying effects were found to be dependent on the activation state of CaSR. Collectively, these results suggest that short-chain aliphatic aldehydes function as taste modulators that modify sensations by activating orally expressed CaSR. We propose that volatile aroma aldehydes may also partially contribute to the taste-modifying effect via the same molecular mechanism as kokumi substances.
Influence of Dried Maitake and Enoki Mushroom Addition on Antioxidant, Potentially Anti-inflammatory, and Anti-cancer Properties of Enriched Pasta
Authors: Szydłowska-Tutaj Magdalena , Szymanowska Urszula , Tutaj Krzysztof , Domagała Dorota , Złotek Urszula
Published: May 2023

The influence of the addition of 2.5, 5, 7.5, and 10.0% of dried Enoki and Maitake mushrooms on the content of bioactive compounds and some pro-health properties of pasta was studied. The qualitative and quantitative analysis of phenolic compounds performed using the LC-MS/MS technique indicated the highest amount of phenolic compounds in pasta supplemented with Maitake. However, all pasta enriched with Enoki mushrooms contained statistically significant-ly higher content of α-glucans in comparison to the control. In samples subjected to gastrointes-tinal digestion, the antioxidant, and potential anti-inflammatory activities were significantly higher than ethanolic and PBS extracts of samples. The ethanolic extracts from pasta fortified with dried Enoki and Maitake mushrooms had higher antioxidant activity (in some of the anti-radical and reducing power assays ) as well as a higher ability to inhibit lipoxygenase (E2.5 and E5 samples) compared to the control sample. Also some in vitro digested samples of pasta en-riched with dried Enoki and Maitake mushrooms showed higher chelating power (E10, M7.5 and M10); reducing power (E5, E7.5, and M10) and lipoxygenase inhibition (E7.5, E10 and M10) than the control. In conclusion, Enoki and Maitake mushrooms can be used for fortification of semo-lina pasta, conferring healthier characteristics of the product.
Tipping Bucket Rain Gauges in Hydrological Research: Summary on Measurement Uncertainties, Calibration and Error Reduction Strategies
Authors: Segovia-Cardozo Daniel A. , Bernal-Basurco Carlota , Rodríguez-Sinobas Leonor
Published: May 2023

Tipping bucket rain gauges (TBRs) have been, and apparently will continue to be one of the most widely used pieces of equipment for rainfall monitoring, being frequently used for the calibration, validation and downscaling of radar and remote sensing data, due to their major advantages–low cost, simplicity, and low energy consumption. Thus, many works have focused and continue to focus on their main disadvantage–measurement biases (mainly in wind and mechanical underestimations). However, despite arduous scientific effort, calibration methodologies are not frequently implemented by monitoring networks operators or data users, propagating bias in databases and in the different applications of such data, causing uncertainty in the modeling, management, and forecasting in hydrological research, mainly due to a lack of knowledge. Within this context, this work presents a review of the scientific advances in TBR measurement uncertainties, calibration, and error reduction strategies from a hydrological point of view, by describing different rainfall monitoring techniques in Section 2, summarizing TBR measurement uncertainties in Section 3, focusing on calibration, and error reduction strategies in Section 4, a discussion and perspectives in Section 5, and conclusions in Section 6, providing an overview of the of the state of the art and future perspectives of the technology.
Real Time Deployment of MobileNetV3 Model in Edge Computing Devices Using Rgb Color Images for Varietal Classification of Chickpea
Authors: Saha Dhritiman , Mangukia Meetkumar Pareshbhai , Annamalai Manickavasagan
Published: May 2023

Chickpea is one of the most widely consumed pulses globally because of its high protein content. The morphological features of chickpea seed, such as colour, texture, are observable and play a major role in classifying different chickpea varieties. This process is often carried out by human experts, and is time-consuming, inaccurate, and expensive. The objective of the study was to design an automated chickpea classifier using an RGB colour image-based model by considering the morphological features of chickpea seed. As part of the data acquisition process, five hundred and fifty images were collected per variety for four varieties of chickpea (CDC-Alma, CDC-Consul, CDC-Cory, and CDC-Orion) using an industrial RGB camera and a mobile phone camera. Three CNN-based models such as NasNet-A (mobile), MobileNetV3 (small), and EfficientNetB0 were evaluated using a transfer learning-based approach. The classification accuracy was 97%, 99%, and 98% for NasNet-A (mobile), MobileNetV3 (small), and EfficientNetB0 models, respectively. The MobileNetV3 model was used for further deployment on an Android mobile and Raspberry Pi 4 devices based on its higher accuracy and light-weight architecture. The classification accuracy for the four chickpea varieties was 100% while the MobileNetV3 model was deployed on both Android mobile and Raspberry Pi 4 platforms.
Is HSP-27 an Emerging Marker of Good Prognosis in Septic Shock Patients – A Pilot Study
Authors: Jaroszynski Andrzej , Wójtowicz Rafał , Piasek Ewa , Dąbrowski Wojciech
Published: May 2023

Is HSP-27 an emerging marker of good prognosis in septic shock patients – a pilot study
Objective
To estimate the value of serum changes of C-reactive protein, procalcitonin, presepsin, heat shock protein 27 (HSP27) and neutrophil to lymphocyte ratio in assessing the prognosis in patients with septic shock (SS) treated in intensive care unit.
Methods
The SS was diagnosed and treated in accordance with the guidelines of the Surviving Sepsis Campaign. 37 selected adult patients with SS were included. Serum concentrations of biomarkers were measured at admission and daily for 4 consecutive days (time points T0,T1, T2, T3 and T4 respectively). The mortality rate was determined 28 days after admission. Patients were divided into survivor and non-survivor groups according to their mortality. The differences between the levels of biomarkers at the T0 and T4 time points were analyzed.
Results
The mean value of the SOFA score on admission was 11.7 ± 2.7, and the APACHE II scale 29.9 ± 6.85. Nine patients died. Univariate logistic analysis revealed that changes between T0 and T4 time points of presepsin, procalcytonin, and HSP27 were associated with prognosis. A multivariate Cox analysis showed that an increase in HSP27 on T4 was the only independent predictor of good prognosis in SS patients. The area under the receiver operating characteristics curve for HSP27 was 0.785. Kaplan–Meier analysis showed that the mortality was lower (p=0.014) in patients who had an increase in HSP27 on T4 compared to those whose serum HSP27 did not increase on T4.
Conclusions
The increase of HSP27 level on the 4th day predicts favorable outcome in SS patients.
Deep Camera-Radar Fusion with Attention Framework for Autonomous Vehicle Vision in Foggy Weather Conditions
Authors: Ogunrinde Isaac Oluwadunsin , Bernadin Shonda
Published: May 2023

AVs suffer reduced maneuverability and performance due to the degradation in sensor performances in fog. Such degradation causes significant object detection errors essential for AVs' safety-critical conditions. For instance, YOLOv5 performs significantly well under favorable weather but suffers miss detections and false positives due to atmospheric scattering caused by fog particles. Existing deep object detection techniques often exhibit a high degree of accuracy. The drawback is being sluggish at object detection in fog. Object detection methods with fast detection speed have been obtained using deep learning at the expense of accuracy. The problem of the lack of balance between detection speed and accuracy in fog persist. This paper presents an improved YOLOv5-based multi-sensor fusion network that combines radar's object detection with a camera image bounding box. We transformed radar detection by mapping the radar detections into a two-dimensional image coordinate and projected the resultant radar image on the camera image. Using the attention mechanism, we emphasized and improved important feature representation used for object detection while reducing high-level feature information loss. We trained and tested our multi-sensor fusion network on clear and multi-fog weather datasets obtained from the CARLA simulator. Our result shows that the proposed method significantly enhances the detection of distant and small objects. Our small CR-YOLOnet model best strikes a balance between accuracy and speed with an accuracy of 0.849 at 69 fps.
PENGAJUAN PENINJAUAN KEMBALI OLEH TERPIDANA ATAS DASAR KEKELIRUAN DAN KEKHILAFAN HAKIM DALAM TINDAK PIDANA NARKOTIKA (Studi Putusan Mahkamah Agung Nomor 78PK/PID.SUS/2015)
Authors: Pangestu Bagus Dwi
Published: May 2023

ABSTRAK: Penelitian ini bertujuan untuk mengetahui Alasan Peninjauan Kembali Oleh Terpidana Atas Dasar Kekeliruan Nyata Dan Kekhilafan Hakim Sebagai Dasar Mahkamah Agung mengabulkan Peninjauan Kembali (Studi Putusan Mahkamah Agung No. 78PK/PID.SUS/2015. Metode penelitian yang digunakan adalah penelitian hukum normatif. Berdasarkan hasil penelitian dengan pembahasan dihasilkan kesimpulan: Pertama, bahwa alasan Peninjauan Kembali yang diajukan Terpidana dalam tindak pidana narkotika yang diputus oleh Mahkamah Agung dengan Nomor Putusan 78PK/PID.SUS/2015 telah sesuai dengan ketentuan Pasal 263 ayat (2) KUHAP yaitu adanya keadaan baru yang menimbulkan dugaan kuat, keadaan sebagai dasar dan alasan putusan yang dinyatakan telah terbukti itu, ternyata telah bertentangan satu dengan yang lain, dan jelas memperlihatkan suatu kekhiIafan hakim atau suatu kekeliruan yang nyata. Kedua, bahwa pertimbangan Hakim menerima alasan Peninjauan Kembali yang  diajukan oleh Terpidana dalam perkara tindak pidana Narkotika yang diputus oleh Mahkamah Agung dalam Putusan Nomor  78PK/PID.SUS/2015 telah sesuai dan dapat dibenarkan dengan adanya fakta hukum persidangan.

Kata Kunci : Putusan Hakim, Peninjauan Kembali, Narkotika

ABSTRACT: This study aims to determine the reason for Reconsideration By Convicted Based On Real Fallacy And The mistake of Justice as the Basis Supreme Court granted Reconsideration (Study Supreme Court verdict No. 78PK / PID.SUS / 2015. The research method used was the normative legal research. Based on research results generated discussion conclusions: First, that the reason for Reconsideration filed in narcotic crime offenders are decided by the Supreme Court Decision No. 78PK / PID.SUS / 2015 has been in accordance with the provisions of Section 263 subsection (2) Criminal Code that is the new circumstances that give rise to a strong presumption, the situation as the basis and reasons stated verdict has proved that, it has been at odds with one another, and clearly shows a kekhiIafan judge or a real mistake. Second, that the consideration of the judge to accept the reason Reconsideration filed by Defendants in criminal Narcotics decided by the Supreme Court in its Decision No. 78PK / PID.SUS / 2015 has been appropriate and justified by the fact the law of the court.

Keywords : Judge's Decision, Judicial Review, Narcotics.
PEMBUKTIAN PENUNTUT UMUM TERHADAP TINDAK PIDANA PEMALSUAN UANG RUPIAH DENGAN TERDAKWA ANAK (Studi Putusan Nomor 4/Pid.Sus-Anak/2019/PN.Trg)
Authors: Pradana Januar Aditya
Published: May 2023

 

ABSTRAK: Tujuan dalam penelitian hukum ini adalah untuk mengetahui pembuktian tindak pidana pemalsuan uang rupiah yang dilakukan oleh terdakwa anak telah sesuai dengan Pasal 184 ayat (1) KUHAP jo Pasal 36 ayat (1) Undang-Undang Nomor 7 Tahun 2011 tentang Mata Uang. Metode penelitian yang digunakan adalah penilitian normatif dengan menggunakan pendekatan kasus. Sumber bahan hukum meliputi bahan hukum primer dan sekunder. Penulisan hukum ini menjelaskan bahwa pembuktian yang dilakukan oleh Penuntut Umum dengan menghadirkan alat-alat bukti yang sah di persidangan telah sesuai dengan ketentuan Pasal 184 ayat (1) KUHAP dan membuktikan terdakwa benar melakukan tindak pidana sebagaimana dalam dakwaan melanggar ketentuan Pasal 36 ayat (1) Undang-Undang Nomor 7 Tahun 2011 tentang Mata Uang.

Kata Kunci: pembuktian penuntut umum,  tindak pidana pemalsuan uang rupiah, terdakwa anak

 
ABSTRACT: This purpose of this legal study is to find out the proof of criminal acts of

counterfeiting rupiahs currency by children in accordance with Article 184 section (1) of the Criminal Code Procedure jo Article 36 section (1) Law Number 7 of 2011 concerning Currency. The research method used is normative research using a case approach. Sources of legal material include primary and secondary legal materials. The writing of this law explains that the evidence carried out by the Public Prosecutor by presenting valid evidence at the trial is in accordance with the provisions of Article 184 section (1) of the Criminal Code Procedure and proves that the defendant is committing a criminal act as in the violation of Article 36 section (1) Law Number 7 of 2011 concerning Currency.Keywords: proof of public prosecution, falsification of rupiah currency, child defendant forensics, considering that electronic evidence is very easy to be changed, engineered and manipulated.

Keywords: Electronic evidence, proof, criminal acts of pornofraphy.
ALASAN PEMERIKSAAN KASASI OLEH MAHKAMAH AGUNG AKIBAT KESALAHAN PENERAPAN HUKUM PEMBUKTIAN JUDEX FACTI (Studi Putusan Nomor 128K/Pid/2017)
Authors: Ratna Furi Desthari Pasaning
Published: May 2023

ABSTRAK: Penulisan   ini   bertujuan   untuk   mengetahui   kesalahan   penerapan   hukum   pembuktian yang   dilakukan  Judex  Facti  yang  dijadikan  alasan  pemeriksaan  kasasi  oleh  Mahkamah Agung telah  sesuai Pasal 253 ayat (1) KUHAP. Metode penelitian yang digunakan adalah penelitian hukum  normatif yang bersifat perspektif dan terapan. Hasil Penelitian menunjukan bahwakesesuaian   dalam  pengajuan  kasasi  oleh  pemohon  kasasi  telah  sesuai  dengan ketentuan yang sebagaimana  mestinya, akan tetapi judex facti dalam memutus salah dalam menetapkan   hukum   yang   diputus    oleh   Mahkamah   Agung   dengan   Nomor   Putusan 128K/Pid/2017 telah sesuai dengan ketentuan  Pasal 253 ayat (1) huruf a KUHAP yang pada pokoknya  menyatakan  alasan  Kasasi  oleh   Pemohon  Kasasi/Terdakwa  dapat  dibenarkan. Judex Facti Pengadilan Tinggi telah salah   menerapkan hukum, atau menerapkan hukum tidak sebagaimana mestinya, dan memuat  memori fakta baru yang belum pernah terungkap di persidangan sebelumnya.

Kata Kunci : Pembuktian, Kasasi, Pembunuhan Berencana
 

ABSTRACT: This  writing  aims  to  determine  the  error  in  the  application  of  the  law  of  evidence  by Judex  Facti which is used as the reason for the cassation examination by the Supreme Court in   accordance  with  Article  253  paragraph  (1)  of  the  Criminal  Procedure  Code.  The research  method used is normative legal research which is perspective and applied. The results of the  study show that the suitability of the appeal filing by the appeal applicant has been in  accordance with the appropriate provisions, but judex facti in deciding wrong in determining  the law decided by the Supreme Court with Decision Number 128K / Pid / 2017 is in  accordance with the provisions of Article 253 paragraph (1 ) letter a KUHAP which in essence  states that the reasons for the Cassation by the Cassation Petitioner / Defendant can be justified.  The Judex Facti of the High Court has wrongly applied the law, or applied the law  inappropriately, and contains memories of new facts that have never been recorded.

Keywords: Strength of Evidence, Family Witness, Divorce Cases
PERTIMBANGAN HAKIM DALAM MENJATUHKAN PUTUSAN PIDANA DALAM TINDAK PIDANA PERZINAHAN (Studi Putusan Nomor : 217/Pid/2018/PT.Sby)
Authors: Iftitah Widya
Published: May 2023

ABSTRAK: Tujuan dalam penelitian hukum ini adalah untuk mengetahui dasar pertimbangan hakim dalam menjatuhkan putusan pidana pada tindak pidana perzinahan sebagaimana diatur dalam Pasal 284 ayat (1) ke-1 huruf b Kitab Undang-Undang Hukum Pidana (KUHP). Metode penelitian yang digunakan adalah penelitian normatif yang bersifat preskriptif terapan dengan menggunakan pendekatan kasus. Sumber bahan hukum meliputu bahan hukum primer dan sekunder. Teknik analisis bahan hukum yang menggunakan teknis analisis kualitatif yang menggunakan pola berpikir deduktif yang kemudian diambil sebuah konklusi. Hasil penelitian penulisan hukum ini menunjukkan bahwa dasar-dasar pertimbangan yang digunakan oleh majelis hakim dalam menjatuhkan putusan pidana dalam  kasus tindak pidana perzinahan ini telah  sesuai dengan Pasal 284 ayat (1) ke-1 huruf b Kitab Undang-Undang Hukum Pidana (KUHP).

Kata Kunci : pertimbangan hakim, perzinahan, putusan.

ABSTRACT: The purpose of this legal study is to known the basis for the judges’s judgment in rendering criminal judgements is committing adultery crimes as set forth in Article 284 verses (1) by-1 character b of the penal code (criminal law). The research methods used predictive and applied normative-law study using a case approach. Sources of legal material include primary and secondary legal material. The collection of legal materials in this research used a qualitative analysis that employs a deductive method pattern that a concession was later obtained. From this legal study shown that the judge’s judgement in the decision for adultery criminal act is consist with Article 284 section (1) by-1 character b KUHP.

Keywords : judges’s judgment, adultery, verdict
PERTIMBANGAN HAKIM PENGADILAN NEGERI CILACAP DALAM MENILAIKETERANGAN AHLI DALAM PEMERIKSAAN PERKARA PENAMBANGAN ILLEGAL (Studi Kasus Pengadilan Negri Cilacap Nomor : 447/Pid.Sus/2018/PN Clp)
Authors: Rinanto Trias Murti
Published: May 2023

ABSTRAK: Tujuan dilakukannya penilitian ini adalah untuk mengetahui pertimbangan hakim Pengadilan Negeri Cilacap dalam menilai keterangan ahli dalam pemeriksaan perkara usaha penambangan illegal (Studi Kasus Pengadilan Negri Cilacap Nomor : 447/Pid.Sus/2018/Pn Clp).Penelitian inimerupakan penelitian hokum doktrin alat aunormatif, bersifat preskriptif dan terapan. Sumber bahan hukum yang digunakan adalah bahan hukum primer dan bahan hokum sekunder, pengumpulan bahan hokum dengan cara studi pustaka, menggunakan pendekata nkasus dan teknikanalisis bahan hokum menggunakan metodesilogisme dan interpretasi dengan menggunakan pola berpikir deduktif. Berdasarkan hasil penelitian ini dapat diambil simpulan bahwa, Keterangan ahli harus dipertimbangkan hakim dalammemutusperkarausaha penambangan illegal. Namun untuk menilai kebenarannya perlu dilihat juga persesuaian tersebut dengan alat bukti lain.

Kata Kunci : Pertimbangan Hakim, Keterangan Ahli, Perkara Penambangan Ilegal

ABSTRACT: The purpose of this research is to find out the consideration of the Cilacap District Court judges in assessing expert statements in the examination of illegal mining business cases (Case Study of the Cilacap State Court Number: 447 / Pid.Sus / 2018 / Pn Clp). This research is a doctrinal or normative legal research, prescriptive and applied in nature. Sources of legal materials used are primary legal materials and secondary legal materials, collection of legal materials by means of literature study, using a case approach and legal material analysis techniques using the syllogism method and interpretation using deductive thinking patterns. Based on the results of this study it can be concluded that, the statement of the expert must be considered by the judge in deciding the caseillegal mining business. However, in order to assess the truth, it is also necessary to look at the compatibility with other evidence.

Key Words: Judge  Consideration, Expert Statement, Illegal Mining Cases

 
Keterangan Ahli Sebagai Alat Bukti Dan Pertimbangan Hakim Tidak Menjatuhkan Pidana Penjara Dalam Memutus Persidangan Perkara Dibidang Perikanan (Studi Putusan Mahkamah Agung Nomor: 491 K/Pid.Sus/2015)
Authors: Prasetya Avarakha Denny
Published: May 2023

Abstrak: Tujuan dilakukannya penilitian ini adalah untuk mengetahui kesesuaian alasan kasasi mengabaikan keterangan ahli tidak menjatuhkan pidana penjara terhadap warga negara  asing  (wna)  dalam  tindak  pidana  dibidang  perikanan  dengan  KUHAP  jo Undang - Undang RI Nomor 31 Tahun 2004 sebagaimana telah ditambah dan diubah dengan Undang - Undang RI Nomor 45 Tahun 2009 tentang Perikanan, sehingga Terdakwa dinyatakan bersalah melakukan tindak pidana dibidang perikanan. Jenis  penelitian  hukum  ini  adalah  hukum  normatif  bersifat  preskriptif  dan terapan. Hasil dalam penilitian ini adalah alasan kasasi mengabaikan Keterangan Ahli tidak menjatuhkan pidana penjara terhadap Warga Negara Asing (WNA) dalam Tindak Pidana  dibidang  Perikanan  telah  sesuai  dengan  KUHAP jo  Undang -  Undang RI Nomor 31 Tahun 2004 sebagaimana telah diamandemen dengan Undang-undang RI Nomor 45 Tahun 2009 tentang Perikanan yaitu Keterangan Ahli merupakan alat bukti yang  sah  untuk  dipakai  sebagai  pertimbangan  Hakim  dalam  memutus  perkara, sehingga dalam memutus perkara Hakim salah dalam menerapkan hukum yang berlaku dan berlakunya hukuman pidana penjara bagi Terdakwa karena terbukti melakukan kejahatan dibidang Perikanan.
Kata kunci: Mengabaikan Keterangan Ahli, Pembuktian, Pertimbangan Hakim

Abstract: The purpose of this research is to know the appropriateness of the reason for the cassation to ignore the expert's explanation not to impose the imprisonment on the foreign citizen (wna) in the criminal act in fishery field with KUHAP jo Law of the Republic  of  Indonesia  Number  31  Year  2004  as  already  amended  by  Law  of  the Republic  of  Indonesia  Number  45  Year  2009  concerning  Fisheries,  so  that  the Defendant was found guilty of criminal acts in the field of fisheries. This type of legal research is a type of normative legal research is prescriptive and applied. The results of this study are the appropriateness of the reasons for the cassation to ignore the Expert’s Testimony not to impose the imprisonment of foreigners in the Criminal Act in the field of Fisheries in accordance with Article 184 paragraph (1) letter b KUHAP jo Article 102 jo Article 5 paragraph (1) b Law of the Republic of Indonesia Number 31 Year 2004 as already amended and amended by Law Number 45 Year 2009 on Fisheries namely Expert’s Testimony is a legal evidence to be used as judges consideration in deciding cases, so that in deciding the Judge case is wrong in applying the applicable law and enforcement of imprisonment for the Defendant as a crime proven in the field of Fisheries.
Keywordrs: Ignored the Expert Testimony, Evidence, Judge Consideration
 