bluuebunny/crossref_metadata_2025 huggingface dataset:
Plausible Influence of HLA Class I and Class II Diversity on SARS-CoV-2 Vulnerability
Authors: Sharma Neha , Sharma Gaurav , Toor Devinder
Published: September 2023

Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the global coronavirus disease 2019 (COVID-19) pandemic, which adversely affected almost all aspects of human life and resulted in the loss of millions of lives, while affecting nearly 0.67 billion people worldwide. SARS-CoV-2 still poses a challenge to the healthcare system as there are more than 200,000 active cases of COVID-19 around the globe. Epidemiological data suggests that the magnitude of morbidity and mortality due to COVID-19 was low in a few geographical regions and was unpredictably higher in a few regions. The genetic diversity of different geographical regions might explain the sporadic prevalence of the disease. In this context, human leukocyte antigens (HLA) represent the most polymorphic gene-dense region of the human genome and serve as an excellent mini-genome model for evaluating population genetic diversity in the context of susceptibility and progression of various diseases. In this review, we highlight the plausible influence of HLA in susceptibility, severity, immune response, and designing of epitope-based vaccines for COVID-19. Further, there is a need for extensive investigations for illustration and clarification of the functional impact of HLA class I and II alleles in the pathogenesis and progression of SARS-CoV-2.
TÜRK MİLLİYETÇİLİĞİNİN PARTİLEŞME SÜRECİ: CKMP’DEN İYİ PARTİ’YE TÜRKIYE’DE MİLLİYETÇİ PARTİLER
Authors: SAVAŞ Ali Rıza , ZABUN Ahmet Hilkmet
Published: September 2023

Fransız İhtilali ile ortaya çıkan ve sonrasında dünyanın önemli bir bölümünü etkileyen milliyetçilik akımı Osmanlı Devleti'ni de etkilemiştir. Osmanlı İmparatorluğu'nun yıkılmasından sonra kurulan Türkiye Cumhuriyeti'nde milliyetçilik hareketi ulus-devlet bilinci olarak kendini göstermiştir. "Türk" ve "millet" kavramlarına yapılan vurgu bu anlamda milliyetçilik göstergesi olarak karşımıza çıkıyor. Cumhuriyet dönemi Türk siyasal hayatında birçok parti kurulmuş ve yönetime talip olmuştur. Bu partiler belirli toplumsal kesimlerin bir araya gelmesiyle ortaya çıkmış ve genelde bir ideolojik hareketin de temsilcileri konumunda olmuşlardır. Sol, sağ, liberal, din ve milliyet temelli siyasal partiler siyasal faaliyetler yürütmüşlerdir. Bu çalışmada çok partili demokratik hayatta Türk milliyetçiliğini hareket noktası olarak kabul eden ya da toplumsal kesimlerce Türk milliyetçiliği bağlamında konumlandırılan partilere ve partileşme sürecine ilişkin tarihsel akış ve karşılaştırmalara yer verilmektedir. İlk olarak, milliyetçilik kavramının ortaya çıkışı, tanımları ve Türkiye'deki milliyetçi hareketlerin teorik çerçevesi ele alınmaktadır. Kavramın çeşitli tanımları yapılmakta ve kökenine ilişkin farklı değerlendirmeler yapılmaktadır. Bu bağlamda milliyetçiliğin vatandaşlık, vatanseverlik, etnikçilik, yabancı düşmanlığı, şovenizm gibi kavramlarla ilişkili olarak zenginleştiği vurgulanmakta, Almanya, İngiltere veya Fransa'nın milliyetçiliğin beşiği olduğu görüşlerine yer verilmektedir. Bu doğrultuda CMKP, MHP, BBP ve İYİ Parti’nin tarihsel gelişim süreçlerine yer verildikten sonra analiz ve karşılaştırmalar yapılmıştır. Değerlendirme aşamasında ise Türkiye'de milliyetçilik vurgusuyla öne çıkan partiler ile milliyetçi olarak algılanan partilere ilişkin karşılaştırma ve değerlendirmeler yapılıyor. Milliyetçiliğin önemli bir oy potansiyeline sahip olduğu ve Türkiye Büyük Millet Meclisi'nde her dönem temsil edilme olanağına sahip olduğu ve yüzde yirmi oy potansiyeline sahip olduğu değerlendirilmiştir.
İRAN'DAKİ SİYASİ AYAKLANMALARIN COĞRAFİ YÖNLER BAĞLAMINDA İNCELENMESİ
Authors: GOLKARIAN Ghadir , HEIDARIBENI Zohreh
Published: September 2023

İnsan davranışları üzerinde bazı faktörlerin etkisi kaçınılmazdır. Bu bağlamda coğrafi faktörlerin etkisi de çok eskilerden beri düşünürler ve Sosyo- kültürel ve Sosyo- psikolog araştırmacıların araştırma alanı olmuştur. Yaşam koşulları, çevre, doğa ve diğer unsurlar insani eylemlerine etki bıraktığı gibi birçok eğilimlerin de ana kaynağı haline gelmiştir. Konu itibariyle, iklimsel koşulların ve doğal çevredeki farklılıkların insan üzerinde olan etkileri ve insanın davranışını belirli reaksiyonlar olarak ortaya koymasına neden olabilmektedir. Herodot ve Aristoteles'ten İbn Sina, Montesquieu ve İbn Haldun'a kadar düşünürler, filozoflar, politikacılar, büyük liderler ve sosyal bilimciler bile, iklim ile insan davranışları arasındaki ilişkiyi araştırmışlar ve üzerinde kanaatlerini ileri sürmüşlerdir.
Hipokrat ve onun takipçileri, MÖ 5. yüzyılda, ikilimin ve coğrafi koşulların insan alışkanlıkları, ahlakı ve fizyolojisi üzerindeki etkisini öne sürmüşlerdir. İran, dört mevsimli bir ülke olarak aynı zamanda çok etnikten oluşan bir ülkedir. Dolayısıyla İran’da yaklaşık 2 asırdan beri siyasi alanda kendini göstermiş olan politik olaylar, devrimsel eğilimler ve protestoların gerçekleşmesinde işte iklimin ve coğrafi faktörlerin etki oranı dikkat çekicidir. İklimin insanla bağlı olarak davranış özellikleri üzerindeki etkisi ile elverişli ve motive edici coğrafi temellerin varlığı da hareketlerin ve isyanların oluşmasında rol oynamıştır.
İran'ın coğrafi yapısına bakılınca, tam bir kavşak niteliğine sahiptir. Bundan dolayı saldırıların, askeri savaşların ve kültürel karşılaşmaların merkezi haline gelmiş ve yıllarca birçok dış etkenlerin etkisine maruz kalarak gerek etniksel gerekse de dinsel değişimleri tecrübe etmiştir ve etmektedir. Bu yüzden İran’ın demografisi farklı ve çok milletlerden oluşan bir ülke sayılmaktadır. Dolayısıyla toplumsal çeşitliliğe neden olan biyolojik ve coğrafi çeşitlilik, farklı coğrafi bölgelerdeki topluluklara özel ve benzersiz bir kimlik kazandırmıştır. Böyle bir durumda meşru hareketin ana aktörleri, diğer coğrafi bölgelerin ve etnik grupların İran'ın statüsünü iyileştirme ve iktidara katılma motivasyonunu oluşturmuştur.
LİDERLİK KAVRAMI BAĞLAMINDA DÖNÜŞÜMCÜ LİDERLİK KURAMININ İNCELENMESİ: MUSTAFA KEMAL ATATÜRK ÖRNEĞİ
Authors: UĞUR Mehmet Güney , ERDOĞAN Mehmet Ferhat
Published: September 2023

Liderlik kavramı günümüzde oldukça önemli bir konu olarak karşımıza çıkmaktadır. Liderlik, bir grubun ya da organizasyonun hedeflerini belirleme, yönetme ve başarma sürecinde belirleyici bir rol oynamaktadır. Bu bağlamda, dönüşümcü liderlik kavramı da son yıllarda giderek önem kazanmaktadır. Dönüşümcü liderlik, liderin takipçilerini destekleyerek, onların potansiyelini ortaya çıkarmasına yardımcı olarak, onları özgürleştirmeye çalıştığı bir liderlik anlayışıdır. Bu liderlik anlayışında lider, takipçilerinin ihtiyaçlarını anlayarak, onların katılımını teşvik eder ve onlara ilham verir. Mustafa Kemal Atatürk de dönüşümcü liderlik örnekleri arasında yer almaktadır. Atatürk, Türkiye Cumhuriyeti'nin kuruluşu sürecinde, toplumda köklü bir değişim yaratan bir liderdir. O, Türk halkının potansiyelini ortaya çıkarmak için çalışmış ve onların özgürleşmesi için mücadele vermiştir. Bu çalışma kapsamında, lider ve liderlik kuramları, bu kuramların teorilerini literatürden faydalanılarak tanımlarını yaparak dönüşümcü lider olarak Mustafa Kemal Atatürk örneği incelenecektir. Dönüşümcü liderde bulunması gereken özelliklerden yola çıkılarak, Mustafa Kemal Atatürk dönüşümcü liderlik özellikleri taşıyan önemli bir liderdir. O, takipçilerinin potansiyelini ortaya çıkarmak için mücadele vermiş ve onların özgürleşmesine katkı sağlamıştır. Liderlik kavramı açısından Atatürk'ün liderliği, dönüşümcü liderlik anlayışının örneklerinden biri olarak gösterilebilir.
Generation of A549 PPM1H BromoTag CRISPR/CAS9 knock-in cell line v1
Authors: Le Cong Huyen Bao Phan Tran
Published: September 2023

This protocol details the generation of A549 PPM1H BromoTag CRISPR/CAS9 knock-in cell line.
Üniversitelerin Ülke Sıralamaları ve İnsani Gelişme Endeksi: Panel Nedensellik Analizi
Authors: GENÇ Elif Güneren
Published: September 2023

Globalleşmenin hızlanması ile birlikte eğitim sektörü de rekabet ortamı içerisinde gelişmesini sürdürmektedir. Artık üniversiteler sadece bulundukları ülke içerisinde değil, diğer ülkelerdeki üniversiteler ile karşılaştırılarak gerek bilimsel anlamda gelişimlerini sürdürmekte gerekse bulundukları bölgelere ekonomik anlamda katkı sağlamaktadırlar. İnsani Gelişme Endeksi (İGE) ise bir ülkenin gelişimini hem ekonomik hem de sosyal yönden incelemektedir. Bu çalışma en başarılı üniversitelerin olduğu ülkeler için oluşturulmuş skorlar ile insani gelişme endeksi arasındaki ilişkiyi Dumitrescu ve Hurlin (2012) tarafından geliştirilen panel Granger nedensellik testi ile 14 ülke için 2003-2015 yılları arasında veri seti kullanılarak incelenmiştir. Çalışmanın sonucunda ülkelerin ekonomik ve sosyolojik gelişim seviyeleri ve üniversitelerin gelişimi arasında çift yönlü nedensellik ilişkisi olduğu ortaya çıkmıştır.
Conscious Self-Regulation and Psychological Well-Being as Resources for Academic Success in Young Adolescents: A Structural Model
Authors: Bondarenko I.N. , Fomina T.G.
Published: September 2023

The problem of psychological resources of academic achievement is the actual problem of psychology and pedagogy. In the present study on the basis of V.I. Morosanova's resource approach to conscious self-regulation and the results of empirical researches the model of relationship between conscious self-regulation of academic goals achievement, psychological well-being and academic performance in young adolescence was verified. Sample: fifth grade students (N=234, mean age M=11,00, SD=0,28). Research methods: V.I. Morosanova's questionnaire "Self-regulation style of learning activity SSUD-M"; "Scale of manifestations of psychological well-being of adolescents"; "Big Five – child version"; "Attitude to learning in middle and high school". The model of academic success predictors describes the mutual determination of self-regulation, personality (Big Five), achievement motivation, and reveals the direction of cause-effect relationships between variables. It is shown that self-regulation, psychological well-being and achievement motivation are instrumental resources of academic performance. The high own contribution and strengthening of the influence of well-being and motivation on academic achievement provides it key role among its psychological resources. The findings are of practical importance for the organization of psychological support for the education of young adolescents during the transition to the secondary school.
Mathematical model of the moment distribution algorithm along the axes of an electric vehicle with a two-motor type
Authors: Zavatsky Alexander M. , Debelov Vladimir V. , Malyshev Andrey N. , Keller Andrey V.
Published: September 2023

BACKGROUND: The development of electric and hybrid vehicles is impossible without the creation of schemes in which torque is generated by electric motors independently on the front and rear axles or on each wheel and the best dynamics is achieved. The development of a function for distributing torque between the axles or wheels of a car is a relevant technical task.
AIMS: Creation of a mathematical model for the torque distribution requested by the driver to the front and rear electric motors in order to assist the course stability system and counteract wheel slip when driving in a turn close to drifting/skidding or driving on surfaces with a low or variable grip coefficient.
METHODS: The algorithm model was built in the MATLAB/Simulink environment, was tested in the model-in-the-loop mode on a simulation model developed in the Simcenter Amesim environment, was tested in the hardware-in-the-loop mode on the LabCar real-time machine (ETAS GmbH) and was tested in a vehicle.
RESULTS: The function based on the abovementioned methods was built in MATLAB/Simulink. Testing in simulation mode on the simulation model developed in Simcenter Amesim was performed and the initial values of calibration parameters were determined. Implementation of the function into the software structure of the prototype and compilation of the executable C-code for the master file loaded into the control unit were completed. Testing of the function implemented into the control unit on the LabCar real-time test rig was carried out. After eliminating the shortcomings identified at the previous stages of testing, calibrations and tests of the function integrated into the vehicle were carried out, which showed the effectiveness of the described torque distribution model.
CONCLUSIONS: The practical value of the study lies in the possibility of using the proposed control laws to develop systems for torque distribution between the axles or wheels of modern vehicles.
Influence of switching sequences on the neutral point voltage balance in a three-level voltage source invertor
Authors: Shishkov Alexander N. , Dudkin Maxim M. , Le Van Kan
Published: September 2023

BACKGROUND:Ensuring the voltage balance of the neutral point of the DC link within acceptable limits is one of the mandatory requirements during the operation of a three-level autonomous neutral point clamped voltage source inverter. It is known that neutral point voltage imbalance can adversely affect the operation of the inverter and the load at all, lead to the failure of both power switches and capacitors in the DC link. Neutral point voltage imbalance mostly often occurs due to the asymmetry of the nominal values of DC capacitors, inconsistent properties of switching devices, asymmetric three-phase load, and also due to the imperfection of the converter control algorithm.
AIMS:Selection of the optimal switching sequence that ensures the smallest deviation of the neutral point voltage and the number of switching of power switches in a three-level voltage source inverter.
METHODS:For an objective comparison of the considered switching sequences and their influence on the neutral point voltage balance, a simulation model of a three-level neutral point clamped voltage source inverter was developed in theMATLAB/Simulinksoftware. To control this inverter, a space vector modulation method was used with three different switching sequences: five-segment, seven-segment and standard.
RESULTS:The topology of a three-level neutral point clamped voltage source inverter is presented. The experimental dependencies of the neutral point voltage deviation error was taken with a change in the modulation coefficient, the frequency of the fundamental harmonic at the inverter output, and load characteristics for three different switching sequences.
CONCLUSIONS:In this paper, the influence of the basic vectors and the influence of switching sequences on the neutral point voltage balance are studied. Combinations of states of large and zero basic vectors do not affect the neutral point voltage. For the medium basic vectors, the neutral point voltage can increase or decrease depending on the operating conditions of the inverter. The small basic vectors significantly affect the neutral point voltage. Considering the abovementioned, the seven-segment sequence that ensures both the optimal balance of the neutral point voltage and the level of switching losses should be considered as the best switching sequence for a three-level inverter.
Modeling of the operation of a disc pump with the wall roughness consideration
Authors: Cheremushkin Viacheslav A. , Lomakin Vladimir O.
Published: September 2023

Background: at present, a small number of studies of disk pumps operating on a low-viscosity liquid have been conducted. In addition, among the existing works, numerical calculations are presented, which have a serious discrepancy with the experiments carried out. This article is devoted to numerical simulation of the operation of a disk pump on water, comparison of the calculation results with experimental data.
Aims: to determine the factors affecting the convergence of the main characteristics with experimental data when performing CFD calculations on a low-viscosity liquid.
Methods: in this paper, a numerical modeling method based on the solution of discrete analogs of the basic equations of hydrodynamics is used. To compare CFD calculations with the experiment, a test bench was created on which two configurations of the impeller were studied.
Results: it is shown that for this type of dynamic machines, it is important to take into account the influence of the roughness of solid walls when modeling their operation on a low-viscosity liquid, since it has a significant effect on the characteristics of the disk pump. The obtained characteristics are compared with experimental data, as well as flow patterns in the flow part.
Conclusions: based on the results of the article, it can be argued that taking into account roughness in numerical calculations of a dynamic pump has a positive effect on convergence with experimental data.
The Use of Umbilical Cord Blood Nucleated Cells in the Treatment of Regressive Autism: A Case Report
Authors: Morozova Yana V. , Smirnov Vladimir N. , Makarov Igor V. , Emelina Darya A.
Published: September 2023

BACKGROUND: Interest in the issue of childhood autism has surged in the recent decades. At the same time, despite the significant progress achieved in understanding the etiological and pathogenetic aspects of the condition, effective ways to treat it have continued to elude us. Stem cell therapy appears to hold great promise in the treatment and rehabilitation of patients with both neurological diseases (cerebral palsy, hydrocephalus) and mental disorders (autism, schizophrenia).
METHODS: This article presents a case report describing the use of nucleated cord blood cells in a patient with regressive autism and resistance to standard therapies. The child’s condition was assessed before treatment and 6 and 12 months after.
RESULTS: Clinical observation, psychometric, and instrumental diagnostic methods led to a significant improvement in the child’s condition in the form of perception development, reduction of somatosensory disorders, normalization of emotional status, and a development of social and communication skills.
CONCLUSION: We assume that the result obtained may be associated with the normalization of the immunological status of our patient thanks to the cord blood cells therapy and consider it necessary to conduct further studies into the effectiveness of the method, taking the pathogenic mechanisms of autism into account.
Инновация и традиция в трактовке демократии в современной идеологии КПК
Authors: Ломанов Александр
Published: September 2023

В современной китайской политической идеологии заметно возросло влияние древней конфуцианской концепции “народа как основы” (миньбэнь). В спорах о соотношении китайской традиции и демократии произошло смещение акцента от поиска рудиментов либеральной демократии в древнекитайской мысли к четкому обозначению присутствия традиционных компонентов в современной идеологии КПК. Из мишени для критики китайская традиция превратилась в инструмент укрепления идентичности и объединения общества. Идеологический поиск нацелен на синтез “китаизированного марксизма” с китайской традицией. Китай встал на путь самостоятельной интерпретации современной модели демократии и ее исторических корней вне связи с догмами и стандартами западного академического мейнстрима. Новая концепция народной демократии полного процесса нацелена на усиление позиций Китая в определении современной демократии. Конфуцианская традиция занимает в этом поиске важное место и сохранит его за собой в обозримом будущем.
Методы нейронауки при изучении мировой политики
Authors: Лебедева Марина , Зиновьева Елена
Published: September 2023

Нейронаука активно развивается и проникает в области социальных научных исследований. По сравнению с другими областями социальных наук нейроисследования в меньшей степени затронули международные отношения и мировую политику, поскольку проведение эксперимента, являющегося основным методом нейронауки, здесь ограничено. Исследовательский вопрос статьи заключается в следующем: какие возможности открываются для изучения мировой политики и, в частности, для исследований международных переговоров при использовании нейронауки? Авторы выделяют четыре направления нейроисследований в области международных отношений и мировой политики: 1) роль когнитивных и эмоциональных процессов, проблема лидерства, сотрудничества и конфликта в международных отношениях и мировой политике при принятии решений и взаимодействии; 2) различия в протекании нейропроцессов у представителей разных культур; 3) возможность переноса данных, полученных нейробиологией, на международные отношения и мировую политику; 4) ограничения и открывающиеся преимущества применения нейронауки в международных исследованиях.
Эмпирические вызовы и методологические подходы в сравнительной политологии (сквозь призму “Политического атласа современного мира 2.0”)
Authors: Мельвиль Андрей , Мальгин Артем , Миронюк Михаил , Стукал Денис
Published: September 2023

Растущие объемы, разнообразие и охват данных в последние десятилетия не только открывают перед учеными новые или меняют уже существующие области исследования, но и превращают данные в значимый элемент политики. В этом контексте эмпирические исследования, ставшие на рубеже XX-XXI вв. мейнстримом политической науки, с одной стороны, претендуют на статус строго научного обоснованного знания, а с другой – сталкиваются с некоторыми опасениями, проистекающими из недоверия и к источникам данных, и к методам их обработки. Реализация консорциумом МГИМО МИД России и НИУ ВШЭ исследовательского проекта “Политический атлас современного мира 2.0” как раз предполагает сбор больших объемов страновых данных: во избежание попадания в ловушку манипуляции ими требуется использовать новейшие подходы к сбору, проверке качества и анализу данных. В статье рассматриваются общие проблемы, связанные со сбором эмпирических баз данных для сравнительных исследований, и предлагается их типология. Показано, как эти проблемы проявляются применительно к проекту “Политический атлас современного мира 2.0”: дан обзор ключевых недостатков, характеризующих существующие базы данных, а также рассматриваются ключевые практики, претендующие на роль современного “золотого стандарта” обеспечения качества собираемых данных. Также рассматриваются преимущества и недостатки ряда популярных методов статистического анализа данных, применяемых в сравнительных исследованиях вообще и использованных ранее в рамках проекта “Политический атлас современности”.
İmalatçı KOBİ’lerin Dijital Dönüşümü: KOSGEB Desteği Özelinde Nicel Bir Araştırma
Authors: SIRKINTIOĞLU YILDIRIM Şükran , DURUKAN Leyla
Published: September 2023

Endüstri 4’ün bileşenlerinden biri olan üretim ve iş süreçlerinin dijitalleşmesi, üretim ve kaynak verimliliğinin artırılması ve maliyetlerin düşürülmesi gibi sayısız avantaj sunabilmektedir. Dijitalleşmenin ülke ekonomilerinin sürdürülebilirliğine katkısından dolayı sanayi politikaları ile KOBİ’ler desteklenmektedir. Bu doğrultuda, çalışmanın amacı, imalatçı KOBİ'lerin dijitalleşmeye yönelik tutumlarının dijitalleşme düzeylerine etkisini analiz etmek ve KOSGEB dijitalleşme desteğinden yararlanan imalatçı KOBİ’lerin desteğe bakış açılarının araştırılmasıdır. Çalışmada nicel araştırma yöntemi kullanılmış olup, örnekleme yöntemi kullanılmamış, tam sayım yapılmıştır. Araştırmaya ilişkin veriler KOSGEB KOBİGEL-KOBİ Gelişim Destek Programından yararlanan imalatçı KOBİ’lerden toplanmıştır. Toplam 105 KOBİ’den toplanan veriler SPSS 26.0 paket programından yararlanılarak analiz edilmiştir. Yapılan regresyon analizi sonucuna göre KOBİ’lerin dijitalleşmeye yönelik tutumlarının dijitalleşme düzeyleri üzerinde olumlu bir etkisi olduğu sonucuna ulaşılmıştır.
Study of prevalence and antimicrobial susceptibility pattern of blood culture isolates from a tertiary care hospital in South India
Authors: Mustafa Maimoona , Anjum Iqra
Published: September 2023

Bloodstream infections progress rapidly to life threatening septicemia and sepsis and hence appropriate rapid management is crucial.

A prospective study was carried out in the department of microbiology where patients with clinical suspension of bacteremia were enrolled and blood culture was performed. The isolates were identified by phenotypic characters and antimicrobial susceptibility performed.

A total of 1200 blood samples were collected out of which 279 were positive for aerobic bacterial growth. was the most commonly isolated organism followed by and . Gentamicin (81.6%), Levofloxacin (75%), Meropenem (88.5%) and (93.8%) showed higher sensitivities when compared to Cephalosporins (55%-68%) and penicillin.

Gram-negative bacteria have high resistance rates and discordant antibiotic treatment can lead to multi-organ involvement. Proper timely institution of empirical treatment and adherence to antimicrobial stewardship guidelines coupled with aggressive management is crucial in saving lives.
Prevalence and molecular characterization of carbapenem resistant gram-negative bacilli in a tertiary care hospital in Mumbai
Authors: Prabhala Srujana , Sundaresan Aarthi , Varaiya Ami
Published: September 2023

Carbapenem (CR) among gram-negative bacteria is a worldwide problem. It is ranked in the highest priority category in the World Health Organization (WHO) global priority list of pathogens.It is responsible for therapeutic failure in both hospital and community-acquired infections.

Identifying and monitoring the local epidemiology of the carbapenem resistant organisms, understanding specific mechanisms underlying the resistance and implementing measures to prevent their spread is the need of the hour.

The aim of the study was to determine the prevalence and molecular epidemiology of Carbapenem resistant Gram negative bacilli in this hospital.

: A retrospective study was carried out in the Department of Microbiology of a tertiary care Hospital in Mumbai from January to December 2022. All Gram negative bacilli from various specimens were identified and antimicrobial susceptibility was reported using the VITEK2 automated system (BioMerieux, Durham, North Carolina) and interpreted as per CLSI 2022 guidelines. The resistant genes in the isolates were detected by Xpert Carba-R assay (Cepheid, Sunnyvale, CA) on request by a consulting physician.

: Out of 2,351 gram negative bacilli isolates, 624 were Carbapenem resistant (26.5%). (59.9%) was the most common CR isolate. Molecular testing was done for 190 of these 624 CR isolates. In which New Delhi Metallo beta lactamase (NDM (33.68%) was the most common resistant gene identified followed by NDM & OXA-48(32.63%).

With the prevalence of Carbapenem resistant isolates in the settings, adherence to infection control practices and stringent implementation of antimicrobial stewardship is crucial to curb the rate of infection.
Thematic interpretation of aerial photographs of forest areas based on conceptual modeling
Authors: Shoshina Ksenia V. , Aleshko Roman A. , Berezovsky Vladimir V. , Vasendina Irina S. , Shoshin Alexey S. , Guryev Alexander T.
Published: September 2023

Earth remote sensing (ERS) is one of the main sources of information about the earth's surface. With the development of unmanned aerial vehicles (UAVs), it became possible to take aerial photographs with high spatial resolution, which can be used to more accurately identify objects. The purpose of the study is to increase the reliability of aerial imagery interpretation by developing a methodology for automated image processing based on conceptual modeling. An analysis of the methods for thematic interpretation of images showed that none of them provides sufficient quality of segmentation without additional adjustment to the subject area. The technique of conceptual modeling of subject tasks is applied, which ensures the adequacy of syntactic representations (including various images) and makes it possible to control the logic of solving problems and reduce the number of errors at the stage of its software implementation. The description of the information system for thematic interpretation of images, which implements the developed methodology, is given. An assessment was made of the reliability of thematic interpretation of images of forest areas. It is shown that the developed technique allowed to improve the identification of forest objects on aerial photographs by 18.6%. The development of this technique can be carried out to determine the characteristics of identifiable trees: age, species, height, and wood stock.
Mobile application for finding the best route on campus
Authors: Dusakaeva Slushash T. , Savinov Vitaly V.
Published: September 2023

The actual task of developing a mobile application for finding the optimal route on a university campus is considered. The mathematical basis for designing a mobile application is the task of finding the shortest route in a graph whose vertices are classrooms, laboratories, libraries, departments, dean's offices, etc. in the buildings of the university.The analysis of the main characteristics of existing mobile applications for walking navigation has been carried out, their advantages and disadvantages have been identified. The well-known algorithms for finding the shortest path in a graph are considered: breadth-first search, greedy algorithm, and Dijkstra shortest path algorithm. For the task under consideration, a software implementation and an auxiliary service have been developed to create maps and bring them to a format in which a graph is automatically created for the correct operation of the application. The novelty of the proposed development lies in the possibility of displaying, adding and editing various maps. Further improvement of the developed mobile application can be carried out in the direction of increasing the accuracy of navigation by combining algorithms for finding paths in a graph, as well as in translating maps from 2D to 3D. The results of the study can be used to find the best routes in other universities.
Safety Evaluation of a Traditional Medicinal Plant, Flemingia vestita Benth and Hooker in Swiss Albino Mice: An Acute and Sub-acute Toxicity Study
Authors: Das Aparmita , Yadav Arun Kumar , Roy Bishnupada
Published: September 2023

Acute and sub-acute oral toxicity assessment of Flemingia vestita root-peel extract was performed in Swiss albino mice as per OECD guidelines 425 and 407. In acute toxicity test, mice were administered extract doses of 175, 550, and 1760 mg/ kg body weight (b.w.), and finally, 2000 mg/kg b.w., limit dose. The treated animals were observed for adverse signs or mortality for 14 days. In the sub-acute toxicity study, mice were divided into seven groups (n = 5). Animals in group one served as control, while group five received acetaminophen to act as positive control. Groups two, three and four of animals were given 75, 150 and 300 mg/kg doses of extract for 28 days. Animals in groups six and seven served as the satellite groups for 300 mg/kg and acetaminophen-treated groups for another two weeks to monitor any delayed effects or reversal from adverse effects. The study was approved by the Member-Secretary and the Chairman, Institutional Ethics Committee (Animal Models) of North-Eastern Hill University, Shillong vide letter number: IEC/MS/Misc./08/dated September 26, 2019. Body weight, relative organ weight, haematological and biochemical parameters, and histopathology of the liver, kidney, intestine and spleen of animals were studied. No adverse effects or mortality of animals was observed at 2000 mg/kg b.w., limit dose. The LD50 of the extract was estimated to be greater than 2000 mg/kg. In a sub-acute toxicity study, a 300 mg/kg dose showed a noticeable decrease in food, water consumption, and body weight. Likewise, haematological observations revealed an increase in leukocyte count, and biochemical parameters showed an increase in aspartate aminotransferase in 300 mg/kg extract dose. In histopathological studies, mildly disrupted hepatocytes were observed in liver sections of high-dose treated mice. The findings suggest that F. vestita root-peel extract is safe for consumption but may cause mild toxicity at a high dose of 300 mg extract/kg b.w.
Utilization of Mating Behavior as a Parameter to Understand Adaptive Response in Drosophila melanogaster using Ethyl Methanesulfonate and Methyl Methanesulfonate
Authors: Divyashree Baladare Udayakumar , Ravindra Kembalu Narayana , Vasudev Venkateshaiah
Published: September 2023

Monofunctional alkylating agents, Ethyl Methanesulfonate (EMS) and Methyl Methanesulfonate (MMS) were used to understand adaptive response utilising mating behaviour as a parameter in D. melanogaster. Selected conditioning and challenging doses of EMS (0.5mM and 15mM) or MMS (0.1mM and 3mM) by larval feeding were tested employing different combinations of crosses. The results have revealed that both EMS and MMS affected courtship elements significantly in different combinations of crosses. Nonetheless, significant increases in orientation, tapping, wing vibration and licking were observed when both males and females were treated with a challenging dose of MMS compared to EMS (p<0.05). On par with this, were also the results of female rejection elements in both the tested chemicals. When conditioning and challenging doses were given after 2 hours of time lag between them to 48±4h or 72±4h aged larvae of D. melanogaster, the results showed that male and female courtship elements significantly reduced compared to the additive effect of respective agents. Similarly, the courtship latency and copulation latency were significantly decreased in contrast to copulation duration which was significantly increased (p<0.05). Thus the results demonstrate the presence of adaptive response in D. melanogaster using courtship elements and the authors opine that mating behaviour can be used as a parameter to analyze adaptive response in D. melanogaster within a short period of time compared to other test procedures.
A construção da cidadania: ser negro, cristão e brasileiro no século XXI
Authors: Silva José Roberto da , Medeiros Aline Carla de Medeiros , Maracaja Patricio Borges
Published: September 2023

O movimento negro, ao lado de outras instituições, lutou durante séculos para conquistar o acesso a cidadania plena. No percurso, desse caminhar a ICAR definiu uma nova mentalidade diante da urgência de praticar, ao lado do movimento negro, uma justiça social que não excluísse os negros de seus direitos sociais.
The Role of Indonesian Islamic Banks in Improving Economic Growth in Indonesia (Analysis of Opportunities and Obstacles of Islamic Banks Post Merger
Authors: . Asriani , Kurniawan Agus
Published: September 2023

This study aims to determine the role of the Indonesian Islamic Bank (BSI) on economic growth in Indonesia after the merger analysis of opportunities and constraints. The research uses a qualitative approach with a field study research design. Data collection techniques were carried out by analyzing interviews and documentations. The results of the study state that the opportunities for Indonesian Islamic Banks in future are very high. Considering that many components support the creation of healthy and reliable Islamic banking. However, the opportunity to become established in Islamic banking cannot be separated from various challenges, both from within and from outside. All challenges need to be faced and solved, in order to sought the right solution for the advancement of Islamic Banking. The role of the economy is related to economic growth caused by the development of capital and funds from Bank Syariah Indonesia, which can increase financing in business and national development. Bank Syariah Indonesia has consolidated assets resulting from the merger of Rp239.56 trillion, making it the largest Islamic bank in Indonesia. The strength of the assets of Bank Syariah Indonesia, also includes intangible assets such as reputation, network, human capital, and management.
Keywords: Merger, Indonesian Islamic Bank, Opportunities, Barriers, Economic Growt
Management of Religious Character Education in the Digital Era: The Role of Schools and Parents' Collaboration
Authors: Adawiyah Rabiatul
Published: September 2023

The development of information technology in the digital era has resulted in various changes in human life. The ease of internet access makes it easy for children to access various shows, which can affect their development. Schools and parents have an important role in managing student character. One of the main characteristics that students must have is a religious character. This study aimed to determine the management of character education in the digital era, which schools and parents can carry out, and the collaborative role of schools and parents in character education management. By employing the library method, this study analyzed as many as 40 articles per research objective to obtain the appropriate formulation. The results showed that character education in the digital era has several opportunities and challenges. Religious character education in the digital era can be carried out by schools, for example, through learning, extracurriculars, school programs, and habituation. Parents also play an important role in character education by supervising, educating, and setting an example. Parents can collaborate with schools in character education management by participating in the management process. The principal plays a crucial role in the collaborative process between parents and schools. Based on the discussion that has been carried out, it can be interpreted that the management of character education in the digital era of collaboration between schools and parents can be carried out by involving parents in managing character education, where the principal plays an essential role.
Keywords: Character building; Digital era; Religious; School; Parent
Reeducation of Terrorist Prisoners to the Acceptance of Unitary State Republic of Indonesia Through Psychological and Religious Intervention
Authors: Thahir Andi , Budi Wiranto Bambang , Amalia Fitri Tin , Wahyuni Citra
Published: September 2023

Re-education is a follow-up intervention that aims to provide a re-understanding for terrorist prisoners. This research consists of two interventions that are psychological and religious for terrorist prisoners in Correctional Institutions in Lampung Province. This study aims to determine whether there is an increase in terrorist acceptance in the Republic of Indonesia through psychological and religious interventions. This research was conducted from 2018 to 2021 involving psychologists, doctors, and masters of the Islamic religion as a facilitator. The results of this study were categorized based on two major themes that are: 1) the terrorist’s knowledge about religious intervention; 2) the increasing knowledge and acceptance toward NKRI through psychological intervention. The results of this study found that the provision of re-education through psychological and religious interventions was able to increase the understanding of the acceptance of terrorists toward the Republic of Indonesia and could improve the perception block that each terrorist had.
Keywords: re-education, psychotherapy intervention, religious intervention, terrorist
Conflict Management in Indonesia Through Religious Moderation
Authors: Amrina Rosada Aulia , . Shonhaji
Published: September 2023

Humans are social beings, so it is in their nature to need other people, but in their interactions disputes often occur which leads to conflict. Indonesian society various tribes, customs, religions and cultures side by side which has the potential to cause conflict. An awareness and understanding of cultural diversity, especially religion, is increasingly needed by the community. In this case, the religious moderation movement needs to be increased. The purpose of this paper is to discuss conflict management in Indonesia through religious moderation. The method used in this research is a descriptive and qualitative one, using library research to obtain data. The theoretical approach used in this study uses Thomas and Kilmann’s theory of conflict management styles.
Keywords: Conflict, Religious Moderation, Conflict Management.
Islamic Boarding Schools on Facing the Issue of Religious Intolerance
Authors: Adnan Reza Faisal , M Iqbal Agung , Widi Astuti Yuliana
Published: September 2023

Indonesia is a multicultural country with various kinds of diversity, including ethnicity, race, religion, and language. However, sometimes in this diversity disturbing problems often arise that can eliminate the meaning of harmony itself. Thus, various sustainable efforts can be made so that this problem does not grow. One of them is by strengthening the value of religious tolerance. In this case, Santri and Pesantren play a special role in the realization of peace in Indonesia and the world. The purpose of this research is to identify to what extent Islamic boarding schools are expected to contribute to solving problems that exist in society. One example of this contribution is in dealing with religious intolerance based on Islam, Rahmatan Lil Alamin. Rahmatan lil Alamin is a concept in Islam that teaches and spreads the culture and philosophy of love, peace and compassion, tenderness and respect for mankind and provides guidance to people. The method used in this research is qualiative in nature. It is descriptive through the use of literature review and library research to obtain the research data. The theoretical approach used is the theory of symbolic interactionism by George Herbert Mead. Using this theory, the results of the analysis can be concluded, stating that through interaction, a socialization process can be formed which sees the development of the mindset and self. If someone is able to interact well, then the intent of each individual or group will be well understood too, thus minimizing the occurrence of intolerance where a person cannot accept an opinion, teaching or belief of others.
Keywords: Islamic Boarding School, Intolerance, Religion, Islam Rahmatan Lil Alamin.
The Benefıts of Ex-Wıfe and Chıldren Post Jurısdıctıon at Relıgıous Court Class 1B Metro and How They Are Fulfilled
Authors: . Jayusman , . Efrinaldi , Jayus Muhammad , Setiana Rachman Evy
Published: September 2023

This study describes the implementation of fulfilling the wife’s livelihood and post-court decisions. Some husbands neglect this obligation. The focus of this research is on the implementation of fulfilling the living expenses of the ex-wife and children after the court’s decision at the religious court class 1B Metro Islamic law perspective. The ex-husband had to previously pay for these obligations based on sadd az-Zarī’ah to help the wife’s economy after the divorce. However, the child’s livelihood after the court’s decision in PA class 1B Metro is not by the provisions of Islamic law. The ex-husband does not pay for the child’s support after the divorce, but only pays it once at the time of the divorce vow, not routinely, and not with a nominal value smaller than the court’s decision.
Keywords: Universitas Islam Negeri Raden Intan Lampung
Work Culture of Tsanawiyah Madrasah During COVID-19 in Bandar Lampung City
Authors: . Mansur , Jamaluddin Z Wan , Anwar Syaiful , Hadiati Eti
Published: September 2023

A Madrasa’s work culture values can influence not only emotional involvement, normative involvement, and job satisfaction, but also physical, emotional, and cognitive participation in the workplace. The purpose of this study was to determine and analyze the implementation of the 5 values of work culture at the Madrasah Tsanawiyah in Bandar Lampung. This research method is descriptive and qualitative in nature, and collects primary and secondary data using observation, interviews, and documentation. Upon collection, data analysis was carried out by reducing, displaying, and verifying the data so that it could be concluded at the end of the analysis. The research locations are as follows: Madrasah Tsanawiyah 1 Bandar Lampung, Madrasah Tsanawiyah 2 Bandar Lampung, Madrasah Tsanawiyah Muhammadiyah, and Private Madrasah Tsanawiyah in Bandar Lampung. The results explain that the implementation of a work culture by the Ministry of Religion is successful in Madrasah Tsanawiyah 1, Bandar Lampung. The Madrasah Tsanawiyah private schools in Bandar Lampung City are not yet optimal and will be improved. The success of implementing the teacher’s example must be carried out in collaboration between the school and parents, because parents are the main figures in the formation of their children’s character, and children will therefore act according to the examples applied during the COVID-19 pandemic.
Keywords: Madrasah Tsanawiyah, Pandemic COVID-19, Work Culture
Islamic Religious Education on the Technological Developments of the Era-Revolutionary Society 5
Authors: Wiliyanti Vandan , Rakhmadi Roby , Octavia Sonia
Published: September 2023

The era of society 5.0 emerged with challenges as well as life obstacles. Society 5.0 has a significant impact on the education sector. Educational institutions are expected to be resilient in the face of emerging changes. Islamic religious education has faced big challenges because the era of society 5.0 puts forth 3 aspects, that of human literacy, data literacy, and technological literacy. The concept of learning Islamic religious education in the era of society 5.0, the benefits of learning this education, and the challenges of it in the era of society 5.0 are the background problems this study explores. This research model uses a literature study or what is commonly referred to as library research and the data collected is reviewed from various sources, including scientific publications and books that focus on these concepts, challenges and innovations of Islamic religious education in society 5.0. The data used are from books and journals. The challenges rose from the fact that there were inadequate human resources and teachers who were mostly elderly. The concepts applied in this learning utilize and create new innovations. The innovation of Islamic religious education learning that is carried out is by using a project-based learning model (PjBL) which is a 21st century learning model based on basic concepts and paradigms. This method is considered to be able to increase students’ motivation in conducting analysis aimed at problem-solving activities and critical thinking.
 Keywords: Society 5.0, Islamic religious education, Islamic religious studies, Revolution-era technology.
Validation of the Arabic Version of Medication Regimen Complexity Index Among Older Patients - Validation of the “MRCI-Arabic”
Authors: Aksoy Nilay , Ozturk Nur , Okuyan Betul , Sancar Mesut
Published: September 2023

The medication regimen complexity index is widely used in clinical practice and many studies, to assess the complexity of medication regimens. The goal of this study is to validate the medication regimen complexity index-Arabic (MRCI-Arabic) version among older patients. Methods: This methodologic study was conducted in older patients (≥ 65 years old) who were native Arabic speakers at a community pharmacy located in Istanbul, Turkey. After the translation and cultural adaptation process finished, medication regimens of 30 patients were evaluated for test-retest reliability three weeks apart by the rater who was a native Arabic speaker. The inter-rater correlation was calculated in study population (n =100). The link between the number of medications and the score of medication regimen complexity was used to assess convergent validity. The difference in the score of pharmaceutical regimen complexity in stratified age groups was used to examine discriminant validity. Results: The inter-rater and test-retest reliability of the MRCI-Arabic total scale and its subsection were extremely high (Spearman’s rho ranged from 0.996 to 1; p <0.001). There was a strong and positive correlation between the total MRCI-Arabic score and the number of medications (r = 0.830; p < 0.001), the number of chronic diseases (r = 0.641; p < 0.001). Conclusion: The Arabic validation of the MRCI is a validated tool that can be used by native Arabic-speaking healthcare professionals to determine the complexity of their patients’ medication regimens.