bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation Between Anti-Topoisomerase I and C-Reactive Protein Antibody Level with Modified Rodnan Skin Score On Systemic Sceloris Patients
Authors: Sumartini Dewi, SpPD, K-R Dr. dr , Wisynu Tresnadi A.B  , Rachmat Gunadi Wachjudi
Published: February 2021

A B S T R A C TSystemic sclerosis is characterized by extensive and progressive organfibrosis processes leading to organ failure and death. Modified Rodnan SkinScore (mRSS) had been used as a clinical parameter of skin fibrosis. Anti-topoisomerase I and C-Reactive Protein (CRP) are potential biomarkers forassessing disease activity. The study was performed to determine theassociation of anti-topoisomerase I and CRP antibodies with mRSS values.We performed an observational analytic study based on primary andsecondary data. Systemic sclerosis patient sera data was obtained fromDewi S et al's study, taken from May 2015 to June 2017. Serum Anti -topoisomerase I antibody and CRP level analysis were performed inDecember 2017.Fifty six samples analyzed. Fifty four subjects (96.4%) out of 56 subjects arewomen with an average age of 37 ± 11 years, 41 subjects (73.3%) hasdisease duration over 2 years, 34 subjects (60.7%) has difuse systemicsclerosis, 41 subjects (73.3%) in steroid therapy and 50 subjects (89.3%) inmethotrexate therapy. The statistical analysis showed no correlationbetween anti-topoisomerase I antibody and CRP levels with mRSS values(r = 0.205, p = 0.064; r = -0.134, p = 0.167), but there was a positivecorrelation of anti-topoisomerase I antibody level with mRSS (r = 0,422 p =0,007) and negative correlation between CRP level and mRSS (r = -0,511 p= 0,001) in diffuse sclerosis systemic.From this study we concluded that anti-topoisomerase I antibody and CRPlevel were not correlated with mRSS, but in patient with diffuse systemicsclerosis there was a positive correlation of anti-topoisomerase I antibodylevel with mRSS and negative correlation between CRP level and mRSS.
Pelatihan Pengolahan Limbah Tempe Menjadi Pupuk Cair Di Desa Payo Lebar
Authors: Lestari Fitria , Susanti Ivoni , Jayati Ria Dwi
Published: February 2021

Desa Payo Lebar merupakan desa yang terletak di Kabupaten Sarolangun Jambi Provinsi Jambi dimana salah satu mata pencaharian masyarakatnya adalah produksi Tempe. Proses produksi tempe memerlukan banyak air yang digunakan untuk perendaman, perebusan, pencucian, serta pengupasan kulit kedelai. Hasil akhir dari proses pengolahan tersebut berupa limbah yang menimbulkan bau tidak sedap sebagai hasil sampingan dari proses fermentasi limbah. Berdasarkan hal tersebut, kegiatan ini bertujuan untuk memberikan keterampilan kepada masyarakat di Desa Payo Lebar untuk mengolah limbah tempe menjadi pupuk cair. Metode yang digunakan dalam kegiatan ini adalah sosialisasi, pemberian pengetahuan awal, dan tahap pemberian pelatihan kepada masayarakat tentang pengolahan limbah tempe menjadi pupuk cair. Hasil dari kegiatan ini diketahui bahwa masyarakat dapat mengolah limbah tempe menjadi pupuk cair yang dibuktikan dengan 97% masyarakat mengetahui alat dan bahan serta prosedur kerja untuk mengolahnya. Simpulan dalam kegiatan ini adalah pengolahan limbah yang baik dan benar akan menghasilkan produk yang berguna untuk kehidupan sehari-hari.
Work Stress Factors in Innures at the Putri Hijau Kesdam I Bukit Barisan Medan
Authors: Prawira Agung , Effendi Ismail , Afriani Miskah
Published: February 2021

One of the jobs that is prone to stress is a nurse. According to PPNI, 50.9% of Indonesian nurses experience work stress. This study was to determine the factors that influence the stress of nurses at the Putri Hijau Level II Hospital, Medan. The research design used was cross sectional with a population of 152 nurses in this study and the sample used a stratified random sampling technique to 60 nurses. Data analysis using binary logistic regression test. Research shows that there is an effect of workload (p = 0.03) and interpersonal relationship (p = 0.03) on nurses 'work stress, while the variables of gender, tenure, career development and role conflict have no effect on nurses' work stress. Workload and interpersonal relationships in the workplace have the potential to cause work stress for nurses. So it is advisable for the management to adjust the physical and mental workload with the capacity and ability of nurses, and strive for a conducive social environment.
Evaluation of Antihypertensive Treatment Inoutpatients at Batang Beruh Helath Centre Sidikalang
Authors: Ginting Indra , Asriwati Asriwati , Sari Mayang
Published: February 2021

Hypertension is a cardiovascular disease with a high prevalence and risk of death in developed and developing countries with blood pressure reach ≥140/90 mmHg. Hypertension is the 3rd cause of death after stroke and tuberculosis, reached 6.7% of the population of deaths at all ages in Indonesia. Results of Basic Health Research (Riskesdas) Balitbangkes showed that the national prevalence of hypertension reached 31.7%. The National Formulary (Fornas) is a list of drugs compiled based on the latest scientific evidence by the National Committee for the Compilation of the Fornas. Evaluation of the appropriateness of antihypertensive treatments in outpatients at Batang Beruh Health Centre Sidikalang seen from the National Formulary was the aim of this study. This research is non-experimental, quantitative descriptive was conducted in May - July 2019 at Batang Beruh Health Centre Jl. Pahlawan Sidikalang, Sidikalang District of Dairi, North Sumatra. The population was 231 hypertensive patients using antihypertensive drugs, with sampling using the Slovin formula, amounted to 70 respondents. Based on the research conducted, in the Calcium Antagonist group, the names of the antihypertensive drugs used are Amlodipine and Nifedipine. Meanwhile, in the ACEIs group, the drug used is Captopril. Whereas in the Angiotensin II receptor antagonist group, the drugs used are Micardis, Valsartan and Candesartan. Whereas in the Diuretic group, the antibiotic used is Furosemide.
Low temperature isomerizational transformation of gas gasoline on modified zeolite catalysts
Authors:   Mammadaliyev Institute of Petrochemical Processes of the National Academy of Sciences of Azerbaijan, Mamedova Malahat Tagi kizi
Published: February 2021

New multicomponent catalytic systems synthesized by modifying zeolites (НМOR17 and HZSM-5) and γ-Al2O3 with metals (Co, Ni), zirconium dioxide and subsequent sulfation and tungestation of the obtained samples. It was shown that the introduction of zirconia into the M/MOR (where M = Co, Ni) system allows one to lower the isomerization temperature by 140-160°С, turning the medium-temperature skeletal-isomerisation catalyst M/MOR into a low-temperature M/MOR/ZrO2. It was found that sulfated Co/MOR/ZrO2/SO42- and Co/HZSM-5/ZrO2/SO42- have a higher isomerization activity, which makes it possible to increase the content of isomeric C5-C6 components with high octane numbers in gas gasoline from 43 to 66%. It was found that upon contacting the gas gasoline with the Co/MOR/ZrO2/SO42- or Co/HZSM-5/ZrO2/SO42- catalytic systems, efficient processing of higher molecular weight C7+ alkanes occurs not only into iso-C5 and C6, but also into n-pentane whose content in contact products rises from 19 to 40%. For the first time it was found that at temperatures of 160-200 °C, impurity gaseous C4- alkanes in the gas gasoline are consumed of when contacted with synthesized catalysts, turning into liquid alkanes. It was established that sulfated catalysts have more isomerizing activity in the low-temperature isomerization conversion of gas gasoline than volframated ones. The effect of the concentration of SO42- ions on the activity of the catalysts was studied and it was found that 2 wt.% is satisfactory for the studied catalysts. The temperature dependence of the activity of the most active of the synthesized catalysts in this process – Co/HZSM-5/ZrO2/SO42-, was studied. The results showed that the optimum temperature for the isomerization functioning of the selected catalyst is 180 oC. The change in the activity of the optimal catalyst (Co/HZSM-5/ZrO2/SO42-) depending on the reaction period was also studied. It was established that with the course of the process, the activity of the catalyst increases and reaches a maximum of 30 minutes work. After this, the activity of the catalyst gradually decreases. In this case, the total concentration of iso-C5 and iso-C6 increases by 22.9% and reaches 66.1%, and the conversion of C7+ components of gas gasoline is 69.2%.
Effect of activation of wollastonite surface by quaternary ammonium salts on the relaxation properties of PVC compositions modified by it
Authors:   Kazan National Research Technological University, Sadykova Dilyara F. , Gotlib Elena M. ,   Kazan National Research Technological University, Kozhevnikov Ruslan V. ,   Komiteks LIN Ltd, García-Triñanes Pablo ,   University of Greenwich
Published: February 2021

It is promising to use wollastonite as a modifier of plasticized polyvinyl chloride compositions. The main advantages of wollastonite are white colour and needle-shaped particles. To improve the compatibility of this filler with a polymer matrix, it is effective to activate the surface of this mineral by quaternary ammonium salts (QAS). Valuable information on molecular motion in modified compositions can be obtained by studying the relaxation processes using dynamic mechanical analysis. In the temperature dependences of the mechanical loss tangent of the PVC compositions in the region of transition from the glassy to highly elastic state, two maxima were observed. It has been established that for compositions modified with both natural and surface treated wollastonite, regardless of the chemical structure of QAS used to activate the polymer. This is probably due to the formation of a boundary layer in which molecular mobility is inhibited because of the interaction of the polymer with the filler. Thawing of segmental mobility in this boundary layer occurs at the higher temperatures than in the PVC matrix. The surface treatment of wollastonite by QAS somewhat shifts the described relaxation transitions to higher temperatures due to an increase in the efficiency of interaction of the components at the interface. The magnitude of the change in the temperature of the segmental mobility, both in the polymer matrix and in the boundary layer, increases with an increase in the degree of activity of the filler surface.
Polyorganosilazanes: production, properties, application
Authors:   Rus Injection, Kontorov Andrey M. , Glushchenko Alexander Yu. ,   Rus Injection
Published: February 2021

A review is given on the class of organosilicon compounds – polysilazanes. The review includes the history of the discovery of silazanes, the main chemical methods for producing silazanes, the main reactions taking place with the participation of silazanes, and the scope of application of silazanes. The review shows the composition of silazanes. The review consists of 40 literature sources. The synthesis of polyorganosilazanes was first described in 1964 by Kruger and Rohov. In the interaction of ammonia with chlorosilanes (ammonolysis), trimeric or tetrameric cyclosilazanes were formed at the beginning and in the subsequent reaction at high temperatures with a catalyst to obtain polymers with a higher molecular weight. Ammonolysis of chlorosilanes is still the most important synthetic route to polysilazanes. The industrial production of chlorosilanes using the Muller-Roch process, first reported in 1940, served as the cornerstone for the development of silazane chemistry. In the 1960s, the first attempts to turn organosilicon polymers into quasi-ceramic materials were described. At this time, suitable (“pre-ceramic”) polymers are heated to 1000 °C. or higher. It was shown that the elimination of organic groups and hydrogen leads to a rearrangement of the molecular network with the formation of amorphous inorganic materials, which show unique chemical and physical properties. Using polymer-derived ceramics, new applications can be discovered, especially in the field of high-strength materials.
Diels-Alder adduct of levoglucosenone with diene Dane approaches to estrogens
Authors:   Ufa Institute of Chemistry of the Russian Academy of Sciences, Faizullina Liliya Kh. , Galimova Yulia S. ,   Ufa Institute of Chemistry of the Russian Academy of Sciences, Khalilova Yulia A. ,   Ufa Institute of Chemistry of the Russian Academy of Sciences, Valeev Farid A. ,   Ufa Institute of Chemistry of the Russian Academy of Sciences
Published: February 2021

Levoglucosenone has established itself as a good Michael acceptor and a powerful dienophile in Diels-Alder reactions, dipolar cycloaddition and in a number of other transformations. In the Diels-Alder reactions of levoglucosenone with 1,3-dienes, chiral derivatives of cyclohexene are obtained, which are valuable products for the synthesis of natural compounds. We previously studied the reaction of the interaction of levoglucosenone with Dane diene under catalytic, thermal conditions, at ultrahigh pressures and microwave irradiation. It was found that as a result of the reaction, 2 adducts are formed – (1S,2S,15S,17R)-9-methoxy-18,20-dioxapentacyclo[15.2.1.02,15.0.5,14.06,11]icosa-4,6,8, 10-tetraen-16-one and its isomer, the product of the double bond migration is (1S,2S,14S,15S,17R)-9-methoxy-18,20-dioxapentacyclo[15.2.1.02,15.0.5, 14.06,11]icosa-5(14), 6,8,10-tetraen-16-one. In this work, we have developed methods for the transformation of these Diels-Alder adducts in approaches to compounds with a steroid skeleton. Thus, based on the obtained Diels-Alder adducts, optically active hydrazone was synthesized. An optimal method for deoxygenation of a keto group proceeding by aromatization of cycle B in (1S,2S,14S,15S,17R)-9-methoxy-18,20-dioxapenta-cyclo[15.2.1.02,15.0.5,14.06,11]icosa-5(14),6,8,10-tetraen-16-one, converting it to sulfide, followed by boiling in the presence of Raney nickel. The resulting compound, 9-methoxy-18,20-dioxapentacyclo-[15.2.1.02,15.0.5, 14.06,11]icosa-5(14),6,8,10,12-pentaenone, is a promising synthetic block for use in the synthesis of estrogen – equilenin. The biological activity of the synthesized compounds was predicted using the PASS computer program, which resulted in the identification of derivatives that are promising for the study of antacid, anti-seborrheic, embryotoxic, and anti-cancer properties.
Synthesis of new 6-hydroxypyrimidine-4(3Н)-onе derivatives
Authors:   Ministry of Health of the Russian Federation Federal State Budgetary Educational Institution of Higher Education St. Petersburg Chemical and Pharmaceutical University, Kuvaeva Elena V. , Kolesnik Denis A. ,   Ministry of Health of the Russian Federation Federal State Budgetary Educational Institution of Higher Education St. Petersburg Chemical and Pharmaceutical University, Kirpikova Ksenia E. ,   Ministry of Health of the Russian Federation Federal State Budgetary Educational Institution of Higher Education St. Petersburg Chemical and Pharmaceutical University, Yakovlev Igor  P. ,   Ministry of Health of the Russian Federation Federal State Budgetary Educational Institution of Higher Education St. Petersburg Chemical and Pharmaceutical University, Kirillova Eugenia N. ,   Ministry of Health of the Russian Federation Federal State Budgetary Educational Institution of Higher Education St. Petersburg Chemical and Pharmaceutical University
Published: February 2021

In this paper, 6-hydroxypyrimidine-4 (3Н)-one derivatives are considered as promising syntones for the creation of new biologically active substances. This is useful since the pyrimidine fragment is a structural component of nucleic acid bases (cytosine, thymine, uracil), uric and orotic acids, coenzymes (flavins and xanthins), a number of vitamins (folic acid, thiamine, pyridoxine, riboflavin). It is worth noting that the pharmaceutical market is widely represented with antitumor (methotrexate, imatinib, tegafur); antiviral (stavudine, zalcitabine, lamivudine, zidovudine, acyclovir, idoxuridine); immunostimulatory (isophone) and sedative drugs (phenobarbital, sodium ethaminal) based on compounds including the pyrimidine cycle. The purpose of the present work is to develop a method for producing new 2,3-diphenyl-5-(alkyl/ phenyl)-6-hydroxypyrimidin-4(3Н)-ones, proving their structure and individuality by NMR spectroscopy and mass spectrometry, elemental analysis and thin-layer chromatography. As a method of producing new 6-hydroxypyrimidin-4(3Н)-ones, a method of condensing N-phenyl-benzenecarboxymidamide with 2-substituted propanedioyldichlorides in the medium of an aprotic non-polar solvent – o-xylene is proposed. The desired products are isolated from the reaction mass using solvent distillation and a reprecipitation method. It was found that maximum yields are achieved with constant stirring of a suspension of N-phenylbenzenecarboxymidamide with a solution of 2-substituted propanedioyl dichloride in o-xylene and further heating of the reaction mass at 144 °C for 4 hours. The individuality of the synthesized compounds was confirmed by thin layer chromatography on Sorbfil® plates in the methanol-dichloroethane (1:9) system, and their structure was proved using modern physicochemical analysis methods: proton magnetic resonance spectroscopy, NMR С13 spectroscopy, mass spectroscopy and elemental analysis.
Ion-exchange properties of solid solutions based on hydrated forms of monovalent metals antimonate-tungstates
Authors:   Chelyabinsk State University, Firsova Olga A. , Filonenko Elena M. ,   Chelyabinsk State University, Lupitskaya Yulia A. ,   Chelyabinsk State University, Bozorov Hurshid N. ,   Chelyabinsk State University, Butakov Anatoly V. ,   Chelyabinsk State University
Published: February 2021

The research of tungsten-antimony crystalline acid (TACA) structural transformations in the condition of ion-exchange and thermolysis of its substituted M+, H+-forms (M+ – Li, Na, K, Ag) were conducted. The data of thermogravimetric and qualitative X-ray phase analyses made it possible to conclude that the thermolysis of TACA and its derivatives proceeds in a wide temperature range from 300 to 1150 K being accompanied by the removal of crystalline water molecules with the formation of phases mixture containing complex antimony oxides of the ( -,  - Sb2O4) modification and WO3. It was shown that compounds based on hydrated forms of monovalent metal antimonates-tungstates are stable up to 1023 K with a pyrochlore-type structure. For pyrochlore-like phases, a monotonic dependence of unit cell parameter a on ion-exchange degree α and the ionic radius of metals r was revealed indicating the formation of solid solutions Мх(Н3О)1–хWSbO6 nН2О (M+ – Li, Na, K, Ag; 0.0≤х<1.0; 0.0≤n<2.0) with a limited range of solubility from the crystal chemistry point of view. Within the framework of the Fd-3m space group, based on the data of X-ray diffraction analysis (Rietveld method), the structural characteristics of TACA and its substituted M+, H+-forms were refined, and a model for populating the corresponding metal ions by crystallographic positions of the pyrochlore-type structure was proposed. Using a complex of physicochemical methods (thermogravimetric, X-ray diffraction analyses and IR spectroscopy), a correlation between the composition of the obtained compounds, structural disorder, and ion-exchange properties were determined. According to the data of thermogravimetry and IR spectroscopy, it follows that the degree of compounds hydration analyzed depends on the nature of the alkaline ion. This allows to conclude that lithium and sodium ions are located in 16d– positions, dragging neutral water molecules into the structure occupying 8b-positions. In this case, potassium ions can partially occupy both 16d- and 8b-positions of the structure.
Gas chromatography-mass spectrometry screening persistent organic pollutant in environmental monitoring of vital activity objects
Authors:   Federal Center for Toxicological, Radiation and Biological Safety, Fitsev Igor M. , Shlyamina Oksana V. ,   Federal Center for Toxicological, Radiation and Biological Safety, Mukharlyamova Aisylu Z. ,   Federal Center for Toxicological, Radiation and Biological Safety, Mokhtarova Saniya L. ,   Federal Center for Toxicological, Radiation and Biological Safety, Rakhmetova Elvira R. ,   Federal Center for Toxicological, Radiation and Biological Safety, Mukhammetshina Aigul G. ,   Federal Center for Toxicological, Radiation and Biological Safety, Nasybullina Zhanna R. ,   Federal Center for Toxicological, Radiation and Biological Safety
Published: February 2021

There are the results of the developed way of organochlorine pesticides (OCP) screening (OCP was classified by the Stockholm Convention (2001) as persistent organic pollutants (POP) by the gas chromatography–mass spectrometry (GC-MS)-detecting method for its simultaneous detection in vital activity objects (food, food raw material, food product, pathological animal material tissues, natural surface of waters) in this article. Preparation of the samples using solid-phase extraction (SPE) on cartridges «Diapak С18 Plus» or using the solid-phase extraction dispersion QuEChERS («quick», «easy», «affordable», «effective», «reliable», «safe») way (which contribute to high degree of detecting compound extraction) is preceding the GC/MS-detecting stage. Among the detecting ones in conditions of GCMS screening OCP are explored compounds that are included in POP «dirty» dozen: α-, β-, γ-isomers of hexachlorocyclohexane (HCH) and its biotransformation product – pentachlorocyclohexene, hexachlorobenzene (HCB), heptachlor, aldrine (HHDN), 2,2-bis(4-chlorophenyl)-1-chloroethylene (p,p'-DDMU), 1,1-dichloro-2,2-Bis(p-chlorophenyl)ethylene (4,4'-DDE), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (4,4'-DDD), 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethane (4,4'-DDT). The necessity of controlling the content of CO3 (caused by its bioaccumulation in vital activity objects) takes part in trophic paths and caused by them violation of the normal microbiota of the human, agricultural animals and plants, connected with practical methods of realization chemical and biological risks monitoring are one of priority directions of the government policy in chemical and biological safety area. The developed way of GC-MS-detecting range OCP is applied for monitoring in food, food raw material, food product, pathological animal material tissues, natural surface of waters. Quantitative detecting the OCP range on a level of GC-MS method sensitivity spend in selective ions (basic and confirmatory ions respectively) registration mode. This method characterizes by limit of detection that don't exceed maximum permissible level (MPL) content OCP in objects of environmental monitoring with a standard deviation 3-4%.
COVID-19 Pandemic and Antecedents for Digital Transformation in the Workplace: A Conceptual Framework
Authors: Olokundun Maxwell , Ibidunni Stephen , Ogbari Mercy , Falola Hezekiah , Salau Odunayo
Published: February 2021

The emergence of coronavirus (COVID-19) has caused us to reconsider our everyday lives around the world. While the ability to work from home is an advantage to many workers, other businesses lack the foundation of the technological infrastructure to give the capacity of “business as usual” without some compromises. The goal of this paper is to develop a conceptual framework on digital transformations antecedents of global workplaces and organizations post-pandemic outbreak. The study emphasized that the most effective transformations point to four antecedents; smart capital allocation for digital initiatives, engagement of appropriate digital tools, talent recruitment, and brand permission. The study concluded that the global pandemic has created a whole new experience for businesses and organizations around the world. Therefore, business executives cannot sit on their laurels any longer and they cannot put off a digital transformation organizational focus. Henceforth, taking the right decisions today would help ensure that businesses are better placed after the pandemic is over.
Deferasirox Effect on Serum Ferritin in Iraq Patients with Hemoglobinopathies: A Single Center Experience
Authors: Hasan Khalaf Hussein , Sofijanova Aspazija , Hassan Luma , Al-Allawi Nasir
Published: February 2021

BACKGROUND: The introduction of deferasirox as an oral iron chelator for hemoglobinopathies has been hailed by many as an important milestone in the management of iron overload in the latter disorders.
AIM: The objectives of the study were to evaluate the effectiveness of deferasirox in patients with hemoglobinopathies and to assess predictors of response.
METHODS: In this cross-sectional study, 160 patients diagnosed with hemoglobinopathies were included retrospectively from Jin hematology and oncology center in Duhok city, Iraqi Kurdistan. The Jin center offers patients with hemoglobinopathies clinical advice, examination, follow-up, treatment, and blood transfusions.
RESULTS: The median age of enrolled patients was 12 years (range 3–34 years), and included 86 females and 74 males. All patients were on deferasirox with a compliance rate of 77.5%. Furthermore, 32.3% were on concomitant deferoxamine at their last follow-up. After a median follow-up of 2.1 years (range 1–4 years), there was a mean reduction of serum ferritin level of −478.7 overall and −821.1 ng/ml in complaint patients (both being significant at p of 0.042 and 0.001, respectively). Univariate analysis revealed that older age at enrollment, and older age at starting therapy, and initial serum ferritin (>3000 ng/ml) were all significantly associated with more mean reduction in serum ferritin; while only the latter remained so by multivariate analysis (p = 0.04).
CONCLUSIONS: Deferasirox was found to be effective in reducing the level of serum ferritin among this cohort of hemoglobinopathy patients, to a degree comparable to that reported in other studies worldwide. Furthermore, there were significant associations between the reduction of serum ferritin level and age, age at starting treatment, drug compliance, and the initial serum ferritin levels.
Wie heeft baat bij de productieactiviteiten? Analyse van het geval Kuregem
Authors: Orban Alexandre , Trenado Corentin Sanchez , Vanin Fabio
Published: February 2021

Gezien de toenemende populariteit van het imago van de “productieve stad” zowel in politieke als in academische kringen in Brussel, is men het er steeds meer over eens dat de productieactiviteiten in de stad moeten worden behouden en zelfs opnieuw moeten worden ontwikkeld. Maar terwijl de publieke actoren – via hun beleid inzake productieactiviteiten en ruimtelijke ordening – de ontwikkeling van nieuwe activiteiten stimuleren, gaan die veranderingen soms ten koste van de oude activiteiten. Al deze productieactiviteiten zijn echter niet identiek gelijk wanneer we kijken naar de lokalisatiefactoren maar ook naar de sociale en economische gevolgen. Dit artikel, dat het resultaat is van de samenwerking tussen twee onderzoeksprojecten, sluit bijgevolg aan op een kwalitatieve en vergelijkende empirische benadering om meer inzicht te krijgen in de realiteit waarmee deze verschillende soorten van activiteiten – zowel oude als nieuwe – overeenstemmen, alsook in de uitdagingen die gepaard gaan met het behoud of de ontwikkeling van die activiteiten.
Evaluating the benefit of adjuvant radiotherapy after extensive lymph node dissection for gastric cancer
Authors: Wang Yu-Nong , Chang Shou-Yi , Hwang Jing-Min , Chang You-Kang , Kao Woei-Yau , Wan Hsiang-Lin , Tzeng I-Shiang , Wu Chao-Chuan
Published: February 2021

Objective:

This study aimed to evaluate whether adjuvant radiotherapy (RT) can improve the treatment outcome of patients with locally advanced gastric cancer who underwent extensive lymph node dissection (ELND).

Materials and Methods:

This retrospective study included patients with gastric cancer pathological stages IIA–IIIC at Taipei Tzu Chi Hospital between 2008 and 2015. Patients (a) aged >80 years, (b) with distant metastasis at diagnosis, (c) with coexisting malignancies, (d) who did not complete the prescribed RT course, and (e) who died 1 month after surgery were excluded. Among 420 patients diagnosed with gastric cancer, 98 were included.

Results:

The median follow-up was 24.5 months. Of 39 patients who underwent adjuvant RT, 38 also received adjuvant chemotherapy (CT). Of 59 patients who did not receive adjuvant RT, only 34 received adjuvant CT. ELND was performed in 67.3% of the patients. The 5-year overall survival (OS) rate was 40%. In the univariate analyses, adjuvant CT regimen, 5-fluorouracil + leucovorin, was associated with worst outcome, while TS-1 was associated with better survival outcome (P = 0.018). The number of involved lymph nodes was strongly related to the OS and disease-free survival (DFS) (P < 0.001). We tried using different numbers of involved lymph nodes as a cutoff point and found that adjuvant RT significantly improved both OS and DFS in patients whose involved lymph nodes were ≥4 (OS, P = 0.017; DFS, P = 0.015). In multivariate analyses, better DFS was associated with negative surgical margin (P = 0.04), earlier disease stage (P = 0.001), adjuvant radiotherapy (P = 0.045), and adjuvant CT regimen TS-1 (P = 0.001).

Conclusion:

Adjuvant RT could improve DFS of patients with locally advanced gastric cancer with or without ELND. When the number of involved lymph nodes is ≥4, adjuvant RT is strongly suggested.
The Role of Social Comparison and Rumination in Predicting Social Media Addiction
Authors: Onat Kocabıyık Oya
Published: February 2021

The aim of this study is to determine the social media addiction levels of university students and examine whether their social comparison orientations and ruminative responses significantly predict social media addiction. The study group consists of 261 university students. “Social Media Addiction Scale”, “Iowa-Netherlands Social Comparison Orientation Measure” and “Ruminative Response Scale, Short Form” were applied to the participants. Frequency, percentage and multiple regression analysis were used to analyse the obtained data. As a result of the study, it was found out that university students were less addicted on social media. As a result of the regression analysis, it was determined that obsessive thinking, deep thinking and social comparison had significant effects in predicting social media addiction. It was concluded that obsessive thinking and social comparison predicted positively, whereas deep thinking alone was not a significant predictor. The obtained findings were discussed in the context of the relevant literature and suggestions were made for further research.
Ev Tipi Bir Buzdolabının Analitik İncelenmesi ve Tasarımı
Authors: AKKAYA Merve , ÇAMDALI Ünal
Published: February 2021

Bu çalışmada ev tipi bir buzdolabının analitik olarak incelemesi yapılmıştır. Bu bağlamda buzdolabının soğutma yükü hesaplanmış, ana ve yardımcı parçaları seçilmiş ve tasarlanan buzdolabının enerji tüketim değeri hesaplanmıştır.
Soğutma yükünün hesaplanmasında transmisyon, infiltrasyon, ürün ısı yükü ve diğer ısı yüklerinin soğutucu ve dondurucu bölümde oluşturduğu etkiler hesaplanmıştır. Ayrıca soğutma yüküne etki eden her bir ısı yükünün, toplam soğutma yüküne olan etkisi araştırılmıştır. İletim ısı yükünün toplam soğutma yükününün % 33,32’sini ve ürün ısısının toplam soğutma yükününün %31,10'unu oluşturduğu görülmüştür.
Son olarak, TSE EN 62552 standardı ve literatürden alınan bilgilere dayanılarak buzdolabının enerji tüketimi göz önüne alındığında, enerji sınıfının A++ olduğu belirlenmiştir.
Impact of Landscaping of Shopping-Mall on Customer Preferences: A Qualitative Study of Shopping Malls located in Karachi
Authors:   Hamdard University, Nasim Shahzad
Published: February 2021

This study aims at finding the impact of landscaping variables such as interior design, decor and other atmospheric variables of shopping malls on the customers’ preferences and purchase intentions. The research is descriptive in nature and is conducted on the shopping malls of the Karachi; a metropolitan city of Pakistan. Data is gathered through interviews of the customers who visited shopping malls frequently. Semi structured questionnaire and content analysis of interviews is used for the analysis of the results. The findings of this study specify that variables like hygiene, aroma, lighting, and display/layout have significant impact on customers’ purchase intention; whereas temperature, music and color found to be insignificant variables.
AZERBAYCAN İLE İLİŞKİLERİ BAĞLAMINDA TÜRKİSTAN DEVLETLERİNİN DAĞLIK KARABAĞ KONUSUNDAKİ TUTUM VE TEPKİLERİ
Authors: ÖZTOPAL Mustafa Kemal
Published: February 2021

Dağlık Karabağ Sorunu başlangıcından bugüne dek birçok bölgesel ve küresel aktör tarafından takip edilmiş; sorunun çözümü için barış görüşmeleri, arabuluculuk faaliyetleri, ateşkes gibi girişimlerde üçüncü taraflar rol oynamaya çalışmıştır. Bu bağlamda değerlendirilebilecek devletlerden bazıları SSCB’nin dağılmasıyla bağımsızlıklarını kazanan Türkistan devletleridir. Bu çalışmanın amacı Azerbaycan’ın Türkistan devletleri ile ilişkileri bağlamında bu devletlerin Dağlık Karabağ konusundaki tutum ve politikalarını analiz etmektir. Bu analiz, Türkistan devletlerinin Dağlık Karabağ Sorununun gelişimi ve 27 Eylül 2020’de başlayan İkinci Karabağ Savaşı konusundaki tepki ve tutumları üzerine yoğunlaşmaktadır.
MÜTAREKE İSTANBULUNDA BİR SİYASİ CİNAYET: KARABAĞLI BEHBUD HAN CEVANŞİR’İN ŞEHİT EDİLMESİ VE TORLAKYAN DAVASI
Authors: BALCI Sezai , ERASLAN Selcan Alperay
Published: February 2021

Azerbaycan Cumhuriyeti’nin kuruluşunda önce İçişleri, daha sonra da Ticaret ve Sanayi Nazırı olarak önemli rol üstlenen devlet adamlarından biri de Behbud Han Cevanşir’dir. Sovyet Azerbaycan’ı kurulduktan sonra 1921 yılında Neriman Nerimanof tarafından petrol hakkında araştırma yapmak üzere gönderildiği Almanya’ya gitmek üzere İstanbul’a gelen Cevanşir, 18 Temmuz 1921 gecesi Beyoğlu’nda Pera Palas Oteli önünde Taşnak üyesi Misak Torlakyan tarafından suikastle katledilmiştir. Torlakyan, İngiliz Divan-ı Harbi’nde yapılan yargılama sonucunda idam cezasına çarptırılmasına rağmen, akıl sağlığı yerinde olmadığı gerekçesiyle tahliye edilerek yurt dışına kaçırılmıştır. Bu makale, katledilmesinin 100. yıldönümünde Torlakyan Davası olarak anılan Behbud Han Cevanşir cinayetini incelemeyi amaç edinmiştir.
KÜREKÇAY ANLAŞMASININ TARİHİ ARKA PLANI, HUKUKİ NİTELİĞİ VE SİYASİ SONUÇLARI
Authors: ASKER Ali , ŞEYBAN Sedanur
Published: February 2021

Karabağ, jeopolitik ve jeostratejik konumu itibariyle yakın tarihimizde Güney Kafkasya coğrafyasının en önemli bölgelerinden biri olarak tanınmıştır. Azerbaycan’ın bölünemez bir parçasını oluşturan Karabağ, tarih boyunca birçok medeniyete ev sahipliği yapmış, Azerbaycan Türklüğünün ilim, kültür ve sanat merkezlerinden biri olarak ün kazanmıştır. XIX. yüzyılın başlarından itibaren Rusya İmparatorluğu’nun güneye doğru ilerlediği bir dönemde Azerbaycan hanlıkları İran merkezî yönetiminden kopma yoluna girmişlerdir. Bu gelişme, Kafkasya’nın işgali açısından Rusya’ya önemli fırsat sunuyordu. O sırada, Kaçar Hanedanı, İran’dan kopma yoluna girmiş hanlıkları yeniden kendi bünyesine katma çabası içindeydi. Azerbaycan hanlıklarının işgal süreçleri Rusya İmparatorluğu tarafından duruma göre tehdit, ikna, savaş vs. gibi yöntemlerle devam ettirilmiştir. Dolayısıyla, Rusya’nın işgal politikasında değişik yöntemlere başvurması gayet doğaldı.
Rus yönetimi birçok hanlıkla iki taraflı anlaşmalar yaparak işgal sürecini meşru ve hukuki bir temele oturtmaya çalışıyordu. Ayrıca Rusya ve İran arasında imzalanan barış antlaşmaları işgal sürecinin Rusya lehine sonuçlandığını hukuken teyit ve tasdik ediyordu. Bu bağlamda Kürekçay (1805), Gülistan (1813) ve Türkmençay (1828), ayrıca Osmanlı ve Rusya arasında imzalanmış Edirne Anlaşması (1829) Karabağ’ın kaderin belirleyen ve istikbalini etkileyen önemli belgelerdir. Keza bu anlaşmalar sonucunda bölgenin siyasi, demografik ve kültürel yapısında önemli değişimler yaşanmıştır. Tarihi kaynakların da doğruladığı gibi, daha önce bölgede son derece seyrek halde yaşayan Ermeni toplumu bu tarihten itibaren yoğun göç politikaları sayesinde kalabalık hale gelmiş, Ermenilerden oluşan yeni iskân birimleri ortaya çıkmıştır. Göç eden Ermeniler, tarih boyunca Türklerin yaşadıkları topraklar üzerinde iskân birimleri oluşturmakla yetinmemiş, aynı zamanda yayılmacı faaliyetlerde bulunarak Müslüman/Türk ahaliyi yurtlarından etmiş, vahşet, mezalim ve kıyım uygulamışlardır. Bölge halkı için büyük felaketlere yol açan bu sürecin önemli olaylarından biri Karabağ Hanlığı ve Rusya arasında Kürekçay Anlaşmasının imzalanması olmuştur.
Design, Fabrication and Characterization of a Solar Fish Dryer
Authors: Tyona MD , Ojiya ED
Published: February 2021

Herein, a forced convection solar fish dryer is designed, constructed and characterized to yield a better main of drying fish. The designed dryer incorporated a heat storage unit which complimented the drying rate of the product during off sunshine hours. The device was characterized during raining and dry seasons and results clearly indicated the influence of seasonal variation on the performance of the device. Average hourly variation of the dryer and ambient temperatures measured on the selected days of the different months of measurement during the two seasons, clearly indicated that temperatures were significantly enhanced by the device. This was due to the high ability of the designed solar collector to trap large amount of long waves. Maximum dryer and ambient temperatures during raining season were measured to be (58.9±2) oC and (40±2) oC whereas, (73.5±1.3) oC and (45±1.8) oC respectively, were measured during the dry season. Average daily moisture loss from the drying fish was notably high, especially during dry season which was due to the high dryer temperatures and decrease in atmospheric humidity. The efficiency of the solar dryer was estimated to be 76 %. The fishes with initial moisture content of 87 % was dried to 13 %. This moisture content is in range with the United Nations Economic Commission for Europe (UNECE) Standard DDP-19 concerning the marketing and commercial quality control of dried fish.
Modified Fuzzy Data Envelopment Analysis Models
Authors: DIKE IJ
Published: February 2021

This paper examines the use of data envelopment analysis (DEA) in the conduct of efficiency measurement involving fuzzy (interval) input-output values. Data envelopment analysis is a linear programming method for comparing the relative productivity (or efficiency) of multiple service units. Standard DEA models assume crisp data for both the input and output values. In practice however, input and output values may be uncertain, vague, imprecise or incomplete. A new pair of fuzzy DEA models is presented which differs from existing fuzzy DEA models handling uncertain data. In this approach, upper bound interval data are used exclusively to obtain the upper frontier values while lower bound interval data are used exclusively to obtain the lower frontier values. The outcome, when compared with the outcome of existing approach, based on the same set of data, shows a swap in the upper and lower frontier values with exactly the same number of efficient decision making units (DMUs). This new approach therefore clears the ambiguity occasioned by the mixture of upper and lower bound values in the determination of the upper and lower frontier efficiency scores respectively.
Estimating the Proportion of Alcohol, Illicit Substance and Drug Users and Impacts on Project Performance in Construction Sites in Adamawa and Taraba State, North Eastern Nigeria
Authors: Jibesen D , Haruna AC , Yamusa IR
Published: February 2021

This study used the Respondent Driven Sampling (RDS) method to estimate the proportion of alcohol Illicit Drug and Substance Users amongst Construction Sites workers in Adamawa and Taraba States of Nigeria. 26 seeds (initial recruits) were selected via convenience sampling from 26 construction sites in the two States with 13 from each state. 330 coupons were distributed to each of the states, making a total of 660 recruits. A behavioural questionnaire was administered on the recruits through the site’s managers. The RDSAT 7.1 software was used for the analysis, taking into account their network sizes and homophily values, while Net-draw was used for graphing the recruitment chains. The result shows that RDS is a reliable means as out of the 660(100%) targeted sample size of recruits, 623(94%) were successfully recruited. Results further revealed that, in both states, artisans of age less than 30 are mostly involved in drug abuse and that carpenters who engaged in drugs/substance/alcohol used incurred the highest cost compare to other trades. It is recommended that the method can be extended to studying other hidden populations in the country.
HENNA (Lawsonia inermis) A MEDICINAL HERB EFFECTIVE IN SICKLE CELL DISEASE
Authors: KUMAR KRISHNA , Nitish Kumar  , Amresh gupta  , Arpita singh  , Pandey Swarnima  , Aquil Siddiqui
Published: February 2021

Sickle cell anemia is a common disease in Oman country. In this disease, sickle-shaped cells are formed. These cells interrupt blood vessels and cause a reduction in oxygen transportation. It was founded that henna (Lawsonia inermis) can prohibit the formation of sickle cells. The Lawsone (2-Hydroxy-1,4-Naphthoquinone) is the constituents of henna which is responsible for the anti-sickling activity, by increasing the oxygen affinity of red blood cells. Hena has the anti-sickling activity which is proved by incubating aqueous and methanolic henna extracts with sickle cell disease patient's whole blood. Then for reduction to oxygen tension 2%, sodium bisulphite was added. Therefore, the percentage of sickled cells to normal red blood cells was observed at 30 minutes intervals. Henna proved a delay in the sickling process in 84% of the tested samples. Both extracts(aqueous and methanolic henna) can delay sickling for about an hour.
PENGARUH KEPEMIMPINAN, LINGKUNGAN KERJA, KOMPETENSI DAN BUDAYA ORGANISASI TERHADAP KEPUASAN KERJA YANG BERDAMPAK PADA KINERJA DOSEN POLITEKNIK ATMI SURAKARTA
Authors: Kartikasari Dewi
Published: February 2021

The purpose of this study are to examine and analyze the influence of Leadership, Work Environment, Competence And Organizational Culture To Job Satisfaction That Impact Lecturer Performance At Polytechnic ATMI Surakarta.This study is a survey research. The data used are primary data by sampling of lecturer at Polytechnic ATMI Surakarta as many as 57 respondents. The data analysis method was tested by validity, reliability test, t-test, F, coefficient of determination (R2) and path analysis test.T test results as follows: leadership not significant effect on job satisfaction, work environment significant effect on job satisfaction, competence significant effect on job satisfaction, organizational culture not significant effect on job satisfaction, leadership not significant effect on performance, the working environment have a significant effect on performance, competence significantly influence the performance, organizational culture not significant effect on the performance, satisfaction significant effect on the performance of work. F test results showed simultaneous variables of leadership, work environment, competence, organizational culture and job satisfaction have a significant effect on the performance of lecturers. Results Analysis The coefficient of determination (R2) shows that 77.7% of faculty performance variation can be explained by the leadership, work environment, competence, organizational culture and job satisfaction while the remaining 22.3% is explained by other factors outside the model. The result of path analysis showed a direct influence on the performance of greater competence than the indirect effect on performance competence through job satisfaction. The direct effect on the performance of the work environment is greater than the indirect effect on the performance of the work environment through job satisfaction. The direct effect on the performance leadership is smaller than the indirect effect of leadership on performance through job satisfaction. The direct effect on the performance organizational culture is smaller than the indirect effect of organizational culture on performance through job satisfaction. Based on the results of total leverage to improve performance would be more effective if through increased competence.
PENGARUH CORPORATE GOVERNANCE TERHADAP NILAI PERUSAHAAN DENGAN KINERJA KEUANGAN SEBAGAI VARIABEL INTERVENING PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2010-2014
Authors: Suwasono Heru , Sridarta Yenni Maria
Published: February 2021

Penelitian ini untuk menguji pengaruh Corporate Governance terhadap nilai perusahaan dengan kinerja keuangan sebagai variabel intervening. Corporate Governance dalam penelitian ini menggunakan indikator kepemilikan manajerial dan kepemilikan institusional.Populasi dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia selama periode 2010- 2014. Pemilihan sampel dilakukan dengan metode purposive sampling dari 142 perusahaan yanggo public diperoleh 10 perusahaan sampel yang memenuhi syarat. Teknik analisis data yang digunakan adalah analisis rasio keuangan untuk mengetahui kondisi rasio keuangan perusahaan dari variabel yang diteliti, analisis jalur (Path Analysis) untuk mengetahui besarnya kontribusi yang ditunjukkan oleh koefisien jalur pada setiap diagram jalur, uji hipotesis menggunakan t-statistik dan F-statistik selain itu juga dilakukan uji asumsi klasik yang meliputi uji normalitas, uji multikolinearitas, uji heteroskedastisitas dan uji autokorelasi. Selama periode pengamatan menunjukkan bahwa data penelitian berdistribusi normal.Berdasarkan uji normalitas, uji multikolinearitas, uji heteroskedastisitas dan uji autokorelasi tidak ditemukan variabel yang menyimpang dari asumsiklasik. Hasil penelitian ini menunjukkan bahwa: 1) CG tidak memiliki pengaruh positif dan signifikan terhadap nilai perusahaan, 2) CG tidak berpengaruh tehadap kinerja keuangan yang diukur dengan ROA, 3) kinerja keuangan yang diukur dengan ROA berpengaruh positif dan signifikan terhadap nilai perusahaan, 4) CG tidak  tidak memengaruhi nilai perusahaan melalui kinerja keuangan. Hasil penelitian menunjukkan kinerja keuangan yang tinggi dapat memberikan nilai tambah kepada nilai perusahaannya, yang tercermin dengan meningkatnya nilai PBV.
MEKANISME GCG, LEVERAGE, PROFITABILITAS, TERHADAP TAX AVOIDANCE PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI TAHUN 2016 – 2018
Authors: Dwiyani Titik , Purnomo
Published: February 2021

Research entitled "Mecanisme GCG, Leverage, ROA on Tax Avoidance " on manufacturing companies listed on the Indonesia Stock Exchange in the period 2016 - 2018 aims to determine the effect of GCG, Leverage, ROA on Tax Avoidance . Proxies used are Kom-I, Kom-A, Kep-I,DAR, ROA, and Tax Avoidance.

The population and research sample are manufacturing companies listed on the Indonesia Stock Exchange in 2016-2018 using the stratified purposive sampling method. Based on these methods 37 companies were obtained that could be used as research samples.

Analysis of research data using multiple linear regression were analyzed using SPSS. The partial analysis test results show the results of GCG affect to Tax Avoidance and Leverage, ROA  not affect Tax Avoidance.