bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship of Computational Innovation with Organizational Culture and Workload
Authors: Sundu Mustafa , Yaşar Okan , Çömlekçi Merve Gizem , Sağbaş Murat
Published: July 2022

Çalışma, kültür boyutları ve iş yükü ile bilişimsel yenilikçilik arasındaki ilişkiyi incelemektedir. Araştırma modelinde bağımsız değişkenler kapsamında; belirsizlikten kaçınma, güç mesafesi ve bireycilik-toplulukçuluk, nicel ve nitel
iş yükü değişkenleri yer alırken, bağımlı değişken olarak bilişimsel yenilikçilik değişkeni ele alınmıştır. Araştırma verileri İstanbul’da çalışan 248 beyaz yakalı çalışandan elde edilmiştir. Veriler SPSS-26 programı ile korelasyon,
regresyon ve aracılık analizine tabi tutulmuştur. Bulgular, kültürün üç boyutu olan belirsizlikten kaçınma, güç mesafesi ve bireyciliğin bilişimsel yenilikçilik ile pozitif ve orta düzeyde ilişkili olduğunu, çalışanların iş yüklerinin
kültür ile bilişimsel yenilikçiliği ilişkisinde aracılık etkisinin olduğunu göstermektedir. Araştırma sonucunda, bilişimsel yenilikçilik öncülleri kapsamında ele alınması gereken önemli değişkenler olduğu belirlenmiştir. Ayrıca,
çalışanların bilişimsel yenilikçilik düzeylerini arttırmak isteyen yöneticilerin, örgüt kültürü ve çalışan iş yüküne önem vermesi gerektiğini ortaya koymaktadır.
An Ignored Word Group in Turkey Turkish: Compound Noun Group
Authors: Bulak Şahap
Published: July 2022

Türkçe söz diziminin hakkında kabul birliği sağlanamamış konularından biri de birleşik isim grubudur. Genellikle farklı bakış açılarıyla ele alınan söz konusu kelime grubunun başta varlığı olmak üzere terim adı, tanımı, yapısı, kuruluşu
ve özellikleri ile ilgili bugüne kadar bir kabul sağlanamamıştır. Bu kelime grubunun dilbilgisi kaynaklarında farklı şekillerde ele alınması, “hanımeli, biçerdöver, gecekondu, günebakan” gibi yapılardan oluşan “birleşik isim grubu”
ile “Yaşar Kemal, Mehmet Akif Ersoy, Mustafa Kutlu” gibi birden fazla kelimeden oluşan kişi adları ya da kişi ad ve soyadlarından oluşan “kişi ismi grubu”nun karışmasına sebep olmuştur. Yapı ve kuruluş bakımından farklı olan bu
iki kelime grubunun başta terim adı olmak üzere tanımı, yapısı ve kuruluş özelikleri ile sınırlarının belirlenmesini zorlaştıran söz konusu durum, zamanla içinden çıkılmaz bir hal alarak sadece birleşik isim grubu ile kişi ismi
grubunun değil, aynı zamanda kelime grupları ve sözdiziminin dolayısıyla da Türkçenin öğrenilmesi ve öğretilmesine zarar verecek boyutlara ulaşmıştır. Bu çalışmada, Türkçe’nin tarihî gelişim ve değişim süreci ile söz dizimi özellikleri
esas alınarak birleşik isim grubu bütün yönleriyle incelenmiştir. Öncelikle birleşik isim grubunun dilbilgisi kaynaklarında farklı ele alınış biçimleri ile bu konuda ortaya atılan benzer ve farklı görüşler eleştirel bir bakış açısıyla
ele alınarak birleşik isim grubu ile ilgili sorunlara dikkat çekilmiştir. Daha sonra bu kelime grubu; terim adı, tanımı, yapısı, kuruluşu, yazılış şekli, unsurları, cümle ve kelime grupları içerisindeki yeri ile cümledeki görevleri
bakımından ele alınarak özellikleri belirlenmiş ve bu özellikler Türk edebiyatının seçkin eserlerinden alınan cümlelerle örneklendirilmiştir. Böylece birleşik isim grubunun tanımı, terim adı, sınırları ve özelliklerinin doğru belirlenmesine,
bu kelime grubuyla ilgili eskiden beri tekrar edilegelen doğruluğu tartışmalı bilgilerin düzeltilmesine, dolayısıyla söz konusu kelime grubunun doğru öğrenilmesi ve öğretilmesine katkıda bulunulmaya çalışılmıştır.
Pengaruh Tingkat Pendidikan Orang Tua Dan Implikasinya Terhadap Pola Asuh Pendidikan Anak Usia Dini Di RA ARROFROF
Authors: Shoppia Tamara , Ichsan Ichsan , Winarti Winarti
Published: July 2022

Pendidikan merupakan hal penting dalam setiap elemen kehidupan manusia, pola asuh (Parenting) yaitu serangkaian tindakan yang ditempuh oleh para orang tua, pada kenyataannya yang ada di Indonesia sebagian besar masih mengacu pada tingkat pendidikan orang tua dan adapula yang mangacu pada pola asuh terdahulu. Tempat penelitian ini berlokasi di sekolah RA ROFROF Kec. Kelapa Dua, dipilihnya lokasi menjadi tempat penelitian karena sekolah ini merupakan tempat peneliti mengajar sejak tahun 2019. Adapun metode penelitian yang digunakan dalam hal ini adalah metode kualitatif, dalam penelitian ini data yang didapat meliputi kata-kata atau cerita langsung dari para informan penelitian. Hasil dari penelitian wawancara yang dilakukan di sekolah RA ARROFROF ini menunjukkan terdapat adanya beberapa faktor yang dapat mempengaruhi pola asuh orang tua terhadap anak, diantaranya: 1) Faktor ekonomi Faktor, 2) Faktor Pendidikan dan 3) Faktor Usia Kesimpulan dari penelitian ini menunjukkan hasil: 1) Pemahaman yang dimiliki oleh orang tua murid di sekolah ARROFROF tentang pentingnya pendidikan anak usia dini termasuk dalam kategori baik.
Improvement of students critical thinking skills through structured inquiry learning models on substance pressure topics
Authors: Nashoihah Lina Ihtimamin , Nurita Tutut
Published: July 2022

The study aimed to describe improving students' critical thinking skills by applying a structured inquiry model to the substance pressure topic. The research design is one group pretest-posttest design. The study was conducted at the eighth-grade junior high schools in Surabaya in the 2021/2022 academic year, which totaled 22 respondents. Data collection techniques in questionnaire and test. The questionnaire analysis used the Guttman scale, which was calculated using the percentage formula. While the data analysis techniques pretest-posttest using N-Gain score, normality test, and paired t-test. An implementation of the structured inquiry model improves students' critical thinking skills. It is shown that the t-test where the significance value of (0.000 <0.05) indicates differences in students' critical thinking skills before and after the structured inquiry model is applied. The average value of Gain evidence the difference-the results were (0.81) in the high category, and 91% of the 22 students experienced increased critical thinking skills in the high category. The implementation of learning using the inquiry model gets a mode value of 4, so it can be categorized as very good. The students gave a response reaching 93.96% in the very good category. In conclusion, a structured inquiry model can improve students' critical thinking skills on substance-pressure topics.
Community Empowerment through Online Training of Drumstick Tree (Moringa oleifera) Cultivation and Its Utilization during the Covid-19 Pandemic for Urban Communities in Kediri, East Java, Indonesia
Authors: Wati Susanti Indriya , Afrianto Whisnu Febry , Putra Rivandi Pranandita , Hidayatullah Taufiq
Published: July 2022

Up to these days, many people globally have not yet realized the wondrous benefits of the drumstick tree (Moringa oleifera), such as citizens living in Kediri, East Java, Indonesia. Each person of the communities in the region mostly has spacious enough yards that can be optimized for drumstick tree cultivation. This community service aimed to (a) enhance motivation in gardening activities of urban communities; b) improve knowledge and skills of urban communities in cultivating, harvesting, and processing drumstick tree; c) increase greenery areas in the house; and d) improve food security and family health during the Covid-19 pandemic. Activities in the present community development were distributing gardening and education packages to the target community of Kediri citizens through online media ranging from planting, maintaining, and processing drumstick trees as a home industry business in order to enhance their income. Participants of these activities were also given some materials regarding the topic in the form of booklets and online collective assistance.
Perbandingan antara Teknologi dan Peforma pada Komputasi Awan (Cloud Computing)
Authors:   Program Studi Teknik Informatika Universitas Singaperbangsa Karawang, Apriliani Nadya , Indra Pratama Arief Riski ,   Program Studi Teknik Informatika Universitas Singaperbangsa Karawang, Yuda Irawan Agung Susilo ,   Program Studi Teknik Informatika Universitas Singaperbangsa Karawang
Published: July 2022

Cloud computing is the best method used for data utilization and organization. Cloud provides resources for humans through the internet. There are many technologies in cloud systems, each using a different type of protocol and method. Multiple tasks can be executed on different servers per second, which cannot be executed on the user's computer. In this study, a systematic review is used which provides information related to the most frequently used techniques or technologies. The most popular technologies used in cloud systems are Hadoop, Dryad and other frameworks. Apart from that, there are many tools used to optimize cloud system performance, such as Cap3, HEP and Cloudburst. This study also reviews in detail about the system in cloud computing, the technology used and the best technology used according to several factors and criteria such as procedure costs, speed cons and prospects. In addition, a comprehensive comparison of the tools used for system utilization in cloud computing is presented
Penerapan Algoritma Genetika (GA) Pada Penjadwalan Pengamanan Lingkungan
Authors:   Program Studi Informatika, Universitas Pembangunan Nasional Veteran Jakarta, Priharananto Religian Restu , Bayu Seta Henki ,   Program Studi Informatika, Universitas Pembangunan Nasional Veteran Jakarta, Nurramdhani Helena ,   Program Studi Informatika, Universitas Pembangunan Nasional Veteran Jakarta
Published: July 2022

This research was conducted to facilitate the making of an environmental safety schedule in RT 6. Genetic Algorithm is a discovery algorithm based on the mechanism of biological evolution. Diversity in biological evolution is the variation according to chromosomes between individual organisms. This chromosomal variation will affect the rate of production and the level of the organism's ability to live. The author builds the application scheduling environmental safeguards using genetic algorithms as an alternative to environmental security scheduling that was previously manually converted into an application so that easier and faster. For the initial stage of the research, the authors seek information about the scheduling system which is still manual. The second stage the author makes a scheduling application using the application to make it more efficient effectively and quickly and minimize the occurrence of clashes. In the third stage, the writer collects citizen data to make a schedule of environmental safeguards. To produce an optimal scheduling writer using a genetic algorithm. The fourth stage provides scheduling results from the data that has been collected and selected randomly with an optimal fitness value. The results of this study are: a web-based application that makes it easy for the user so that when making a security schedule, do not use the manual method because it takes 2 hours, while using the application only takes 2 minutes
Sistem Informasi Administrasi Pelaporan Realisasi SKPD Berbasis Web Pada Bappeda Kabupaten Kuburaya
Authors:   Universitas Bina Sarana Informatika, Rahayuningsih Panny Agustia , Fradinata Fradinata ,   Universitas Bina Sarana Informatika
Published: July 2022

Each Regional Apparatus Work Unit (SKPD) must report the use of the budget or realization report to BAPPEDA. Each SKPD officer submits a realization report to the Secretariat. If an error occurs in the preparation of the realization report, the wrong SKPD will be informed again and must re-create and repeat the administration process for reporting realization. This is deemed ineffective, because each SKPD must come to the office only to submit a realization report and also charge officers who fill in the realization data for each SKPD. Therefore, this writing contains research to solve the problems faced by BAPPEDA Kubu Raya Regency by building a web-based SKPD realization reporting administration information system that uses the waterfall model as a software development model consisting of analysis, design, coding, testing. and supporters. Data collection techniques used consisted of observation, interviews and literature study. This system provides facilities to two (2) levels of users, namely Secretariat officers and SKPD officers. Secretariat officers can manage SKPD data, users, descriptions, programs, activities, access RKA-SKPD reports and realization reports. SKPD officers can change SKPD data, manage users, manage RKA-SKPD, access RKA-SKPD reports (personal), manage realization transactions and access realization reports (personal). This system is made using hypertext preprocessor (PHP) programming language, hypertext markup language (HTML), cascading style sheet (CSS), jquery, javascript and bootstrap as well as codeigniter as a framework, MySQL as a database application and sublime text as a web editor. This system is expected to help and be used as a tool in the administration of reporting on the realization of SKPD at BAPPEDA Kubu Raya Regency
Breast lumps: Types, biomarkers and prognosis
Authors: Ahmed F. Hameed  , Khalida I. Noel  , Israa S. Ajeel
Published: July 2022

Introduction: The breast is a dynamic organ in the female and the symptoms related to it considered a major cause enrolled the women to get medical intension, a complete physical, radiological, and cytological examination should be accomplished until the symptoms resolved or benign\ malignant condition established, there were many types of benign tumor in the breast: solid or cystic, painless or painful with different ways for management either by close surveillance or by surgical removal. But the breast cancer required hard work to establish the histological and pathological grade. Conclusion: to treat the breast cancer properly the cancer should stratify into molecular entities by using hormonal biomarker (ER, PR) and using of oncoprotein HER2 and proliferating index Ki-67, usage of these markers is satisfying for grouping the breast cancer subtypes into four major entities which are Luminal A, Luminal B, HER2+, and triple negative tumor.
Green synthesis of silver nanoparticles from various plant extracts and its applications: A mini review
Authors: Arun Kumar Pradhan  , Sameer Ranjan Sahoo  , Swapnashree Satapathy  , Snehalata Pradhan  , Jyoti Sankar Prusty  , Subham Preetam
Published: July 2022

Developing environmentally acceptable and reliable nanoparticle production technologies is a crucial step in nanotechnology. Because of their unique chemical, physical and biological properties, AgNPs have the potential to be used in various ways. As potential agents, biomolecules got from a variety of plant components were used to make it. Despite many academic efforts in the previous decade, synthesizing stability with greater applicability remains a serious challenge. This review reviewed the most recent advancements and breakthroughs in the manufacture of biogenic AgNPs, as well as their potential uses.
Digital-Biotechnology: A Framework of Bioinformatics used Mobile-Health Technologies in Nigeria-Universities 5G-Readiness Deployment-Plan
Authors:   Institute for Advanced and Smart Digital Opportunities, School of Computing,  Universiti Utara Malaysia, Kedah, 06010 Sintok, MALAYSIA, Birnin-Kudu Abdullahi Hassan ,   Faculty of Computing and Information Technology, Federal University Dutse, Dutse, Jigawa State, NIGERIA,   Digital Technology Knowledge Development Center: Sarkin Kudu Hassan Jibril Memorial Development Foundation,     No.2 Bodan Street Birnin Kudu Jigawa State, NIGERIA, Awang Hapini ,   Institute for Advanced and Smart Digital Opportunities, School of Computing,  Universiti Utara Malaysia, Kedah, 06010 Sintok, MALAYSIA, Sheik Osman Wan Rozaini ,   Institute for Advanced and Smart Digital Opportunities, School of Computing,  Universiti Utara Malaysia, Kedah, 06010 Sintok, MALAYSIA
Published: July 2022

Digital Bioinformatics Innovation Initiative (DBII) is a branch of science that used Information and Communication Technologies (ICTs), government electronic services such as electronic government (e-government), electronic health (e-health), and mobile technologies (mobile health) to examine knowledge and information. DBII can also use Internet services or Fourth Generation (4G), and Fifth Generation (5G) services for its deployment and implementation opportunities in developing nations health and healthcare system and other domains. Some of the current digital bioinformatics processes are geometadata profiling, use of mobile technologies (mobile phones) and Artificial Intelligence (AI) in various 5G readiness deployment fields. Despite the benefits of this novel digital innovation, its deployment and implementation have been affected by poverty, lack of enough routine anticipation and determination, initial understanding of mobile phone, inadequate of research funding, personal innovativeness, lack of stable and dependable research methodologies. At present, there is limited number of research that highlighted these aspects to fill in research gaps and find alternative solution to DBII research problems. Therefore, a pilot survey was conducted among professionals in various fields who are knowledgeable about DBII from February 20th, 2020, to January 1st, 2022. Eight academic research professionals, and fifteen health and healthcare workers validated 6 behavior intention factors. Similarly, six hundred postgraduate and undergraduate students, health and healthcare specialists and other professionals across six Nigerian geographical zones participated in pilot survey using the proposed Precaution Adoption Model Process (PAMP) Mobile health questionnaire. Under this situation Principal Component Analysis (PCA) pre-processed online geometadata profiles, experts confirmed behavior intention items towards hypothesis generation, hypothesis testing, and development of digital bioinformatics framework of to use mobile phones in Nigeria Universities 5G readiness deployment plan. The study has discussed several theoretical and practical implications of digital bioinformatics for system designers and developers.
Arti dan fungsi bejana batu berbentuk lembu di Situs Batu Banteng, Situbondo, Jawa Timur
Authors: Galeswangi Rakai Hino
Published: July 2022

Bejana batu berbentuk lembu yang terdapat di Situs Batu Banteng, Selobanteng, Banyuglugur, Sitobondo, Jawa Timur memiliki ciri khas berupa prasasti berangka tahun 1325 Śaka  (1403 M). Artikel ini bertujuan untuk menjelaskan arti dan fungsi bejana batu tersebut melalui metode penelitian kualitatif yang meliputi studi pustaka, transliterasi, dan penerjemahan prasasti. Bejana batu di Situs Batu Banteng menunjukkan adanya indikasi pergeseran dari konsep tambragomukha dalam ajaran Buddha Mahayana menjadi sarana penyucian dosa sebelum seseorang memasuki mandala kadewaguruan.
Pemanfaatan sumber daya alam masa prasejarah berdasarkan temuan arkeologis Gua Arca, Pulau Kangean, Jawa Timur
Authors: Alifah Nfn. , Widianto Harry , Arrozain Mohammad Dziyaul Fikriy , Purnamasari Rizka , Suniarti Yuni , Ansyori Mirza
Published: July 2022

Tulisan ini membahas tentang eksplorasi dan pemanfaatan sumber daya alam oleh penghuni gua. Data yang digunakan dalam tulisan ini adalah hasil ekskavasi situs Gua Arca di Pulau Kangean, Sumenep, Jawa Timur. Metode yang digunakan deskriptif dengan analisis ekofak dan analisis residu mikrobotani pada artefak. Hasil penelitian menunjukkan adanya pola adaptasi dari penghuni pulau ini, dengan melakukan eksplorasi maksimal terhadap sumber daya alam di darat dan laut. Pada periode awal hunian sekitar 6000 BP, terjadi pemanfaatan sumber daya darat yang cukup dominan berupa binatang dengan habitat hutan terbuka, yaitu Cervidae, Bovidae, Macaca sp., dan binatang kecil seperti Cercopithecidae, Rodentia dan Varanidae. Pada periode setelahnya, sekitar 900 BP, terjadi perubahan pemanfaatan sumber daya alam.  Pemanfaatan sumber daya laut menjadi lebih dominan, yang sebagian besar diperoleh dari lingkungan perairan mangrove dan daerah pasang surut. Tumbuhan yang dimanfaatkan antara lain pisang liar, padi liar, kelapa, umbi, dan penggunaan intensif tanaman Zingiberacea.
Sex Differences in Muscle Activity During Drop-Jump Landing Motion
Authors:   Takasaki University of Health and Welfare (Japan), Itota Orthopedics Meieki Sports Clinic (Japan), Nakagawa Kazumasa , Takamatsu Reika , Matsushima Miku
Published: July 2022

This study investigated the effect of hip joint muscles' activity on dynamic knee-joint valgus angle during one-leg drop-jump landing motion in male and female subjects. Twenty-four healthy university students (11 males and 13 females) participated in the study. Surface electromyography was used to measure muscle activity during a one-leg landing motion. A gender difference was observed: males showed greater activity in the gluteus medius muscle compared to the adductor magnus muscle, whereas females showed greater activity in the rectus femoris muscle. A correlation between lower limb muscle activity and knee-joint valgus angle was found in male subjects but not in female subjects, suggesting that factors other than muscle activity are necessary for controlling knee joint valgus in females. Therefore, factors other than muscle activity should be investigated in the future to prevent female anterior cruciate ligament injuries.
Initiating a National Criminal Law Profile in the Future in Indonesia
Authors:   Universitas Pancasakti Tegal, Indonesia, Hamzani Achmad Irwan , . Mukhidin
Published: July 2022

The Indonesian nation does not yet have its product national criminal system. The current national criminal law system is the legal system left by the Dutch colonialists. The national criminal law system must be built based on the ideals of the nation contained in the Preamble to the 1945 Constitution. The research aims to formulate a future profile of national criminal law in Indonesia. This research uses a philosophical approach, which is to analyze the ideal law in the future. Data were analyzed qualitatively. The results of this study indicate the existence of criminal law in society as crime prevention through criminal law laws. Criminal law has a repressive and preventive function. Criminal law is part of the overall law that applies in a country in implementing criminal provisions. The Indonesian nation needs its own national criminal law system. The national criminal law is a criminal law based on Pancasila and the 1945 Constitution which applies nationally in Indonesia. Having its national criminal law for the Indonesian people is an effort to reveal national identity by the hopes and ideals of the independence of the Indonesian nation. The national criminal law profile ideally is the ideal of Pancasila law which is the perspective of the Indonesian people and places the bonds of togetherness and kinship ties as the core of the social life of the Indonesian people. The national criminal law system must be oriented to three pillars, namely: oriented to the values of “God”; oriented to the values of “Humanity”; and oriented to “Society” values.
Intra- and Interobserver Reliability of Superb Microvascular Imaging (SMI) Doppler for Assessing Placental Microvasculature
Authors: Garcia-Jimenez Rocio , García-Mejido José Antonio , Valero Irene , Fernandez-Palacin Ana , Borrero Carlota , Sainz-Bueno Jose Antonio
Published: July 2022

Objective: Superb Microvascular Imaging (SMI) Doppler is a novel technique. We aim to evaluate intra- and interobserver reliability of SMI Doppler for the assessment of normal placental microvasculature. Materials and Methods: A prospective observational study was conducted including 11 pregnant patients. Ultrasonography placental assessment was performed on 28-weeks pregnant patients, by two expert examiners using SMI Doppler in one single visit. To evaluate interobserver reliability, the first examiner took measurements using SMI Doppler, followed then by the second examiner. Afterwards, the first examiner performed a second evaluation, in order to assess intraobserver reliability. Intraclass correlation coefficients (ICC) and Cohen’s Kappa coefficient, and their 95% confidence intervals, were estimated for quantitative and qualitative parameters, respectively. Results: Intraobserver reliability was found to be excellent for all quantitative parameters, with all ICC values above 0.97. For qualitative variables, excellent reliability was obtained for the number of secondary villi, while the number of tertiary villi had an adequate reliability with a Cohen’s Kappa coefficient of 0.792 (95% CI 0.38–1.17; p = 0.007). Interobserver ICCs ranged from 0.92 to 1.00 for all quantitative parameters, thus finding excellent interobserver reliability for all of them. An excellent reliability was also obtained for the number of secondary villi, while the reliability for the number of tertiary villi was found to be adequate. Conclusions: Our findings show that placental microvasculature measurements obtained by a single or two different examiners are reliable and reproducible. The good intra- and interobserver reliability results of SMI Doppler showed in our study stress the value of this technique in the evaluation of placental microvasculature, and thus research in this field is the step forward for the assessment of placental insufficiency.
A case report of uterine rupture after repeated conservative treatment for adenomyosis
Authors: Kwack Jae Young , Kwon Yong-Soon , Im Kyong Shil , Jeong Hyeyoon , Lee Youngeun
Published: July 2022

Background: Among the pregnancy complications after an adenomyomectomy, uterine rupture is fatal for both the mother and baby. There have been a few reports of uterine rupture during pregnancy related to adenomyosis or adenomyomectomy. Case: A 34-year-old nulliparous woman with abdominal discomfort at 27 weeks of gestation visited our clinic. She had a history of complex treatments for symptom relief and fertility for uterine adenomyosis, which included repeat adenomyomectomies and high-intensity focused ultrasound (HIFU). Three months after her last adenomyomectomy, she conceived by in vitro fertilization. During antenatal care at our clinic at 27 weeks of gestation, the results of an examination for abdominal discomfort with focal tenderness on the lower abdomen was suspicious for uterine rupture and fetal distress. An emergency cesarean delivery was performed. The mother’s uterus was repaired without significant postoperative complications and the neonate was admitted to the intensive care unit for prematurity care and presently is well. Conclusions: During antenatal care of a pregnant woman with a history of adenomyosis treatment, heightened awareness of catastrophic pregnancy-related complications should be maintained to obtain the best maternal and fetal outcomes.
Oral Microbiota Changes during Orthodontic Treatment
Authors: Santonocito Simona , Polizzi Alessandro
Published: July 2022

Orthodontic treatment has become increasingly popular due to its benefits in improving facial and smile aesthetics, self-esteem and the function of the stomatognathic apparatus. However, orthodontic appliances make it more difficult to brush teeth effectively, as they interfere with tooth brushing and facilitate the accumulation of dental plaque (biofilm), which induces a quantitative and qualitative change in the oral microbiota. It can cause several adverse effects, such as gingivitis, periodontitis, white spot lesions (WSL), caries and halitosis, induced by an increase in periodontopathogenic and cariogenic bacteria. Therefore, this article resumes the main findings on the changes in the oral microbiota induced by different orthodontic appliances (removable, fixed and clear aligners) and gives some practical strategies in order to reduce the impact and/or incidence of local dental/periodontal complications.
Short-term Variability of Macro- and Trace Elements in Elymus Repens L. and Urtica Dioica L.
Authors: Shtangeeva Irina , Niemelä Matti , Ryumin Alexander , Chelibanov Vladimir , Golovin Alexander , Vesavaara Ilkka , Perämäki Paavo
Published: July 2022

Background: The main aim of the research was to study short-term changes in the concentrations of elements in two widely distributed plant species, couch grass and nettle and in the rhizosphere soil of the plants. Methods: The sampling of plants and soil was carried out on three dates: 3, 10, and 25 May 2021. On each day of sampling, the plants and soil were collected three times: at 9:00, 14:00, and 19:00. The ICP-OES and ICP-MS analytical techniques were used for determination of elements in the plant and soil samples. The Raman spectroscopy was applied to study variations in the organic compounds. Results: The concentrations of both macro-nutrients and trace elements in plants varied greatly over daytime on all dates of sampling. The differences between concentrations of many elements in the plants collected at different times during a day were statistically significant. There were also statistically significant differences between concentrations of some elements (Na, Mg, P, K, Fe, Ba) in the plants collected on different dates. The relative intensity of diffuse luminescence of the rhizosphere soil of couch grass and nettle was different during daytime and also differed between the soils taken from roots of the two plant species, especially in the beginning of May. Conclusions: The experimental data indicates that the daily variations of the element concentrations in plants might be a result of multiple effects of various factors. The differences in the daily element variations in the couch grass and nettle growing in the same site and collected simultaneously might be due to the fact that these plants belong to different clades. The diurnal fluctuations (that also include regular changes in the element concentrations in plants) can be different for monocotyledons (couch grass) and dicotyledons (nettle). New experimental findings on short-term variations in the concentrations of macro-nutrients and trace elements can help to gain a new insight into accumulation of the elements in different plant species and also be useful in agricultural practice.
Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma
Authors: Ghorani-Azam Adel , Mottaghipisheh Javad , Amiri Mohammad Sadegh , Mashreghi Mohammad , Hashemzadeh Alireza , Haddad-Mashadrizeh Aliakbar , Nourbakhsh Fahimeh , Nadaf Mohabat , Qayoomian Mohsen , Taghavizadeh Yazdi Mohammad Ehsan , Vitalini Sara , Iriti Marcello
Published: July 2022

Background: In the present study, resveratrol was used to prepare complexes of cerium and nanoceria, also coated with gold (CeO2@Au core-shells) to improve the surface interactions in physiological conditions. Methods: The CeO2@Au core-shells were characterized using powder X-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), transmission electron microscope (TEM) analysis, dynamic light scattering (DLS) and ζ potential. Results: The experiment was led to the successful synthesis of nanosized CeO2@Au core-shells, although agglomeration of particles caused the distribution of the larger particles. The TEM analysis demonstrated the particles sizes ranged from 20 nm to 170 nm. Moreover, the PXRD analysis showed that both nanoceria and gold with the same crystal systems and space groups. To investigate the anticancer activity of the CeO2@Au core-shells, the cytotoxicity of the nanoparticles was investigated against liver cancerous cell lines (HepG2). Conclusions: The results indicated biosynthesized NCs have significant cellular toxicity properties against HepG2 and could be utilized in hepatocarcinoma therapy. Further in vivo investigations is proposed to be designed to assess anti-cancer and safety effects of fabricated nanocomposites.
Using the BMD Approach to Derive Acceptable Daily Intakes of Cannabidiol (CBD) and Tetrahydrocannabinol (THC) Relevant to Electronic Cigarette Liquids
Authors: Hindelang Pascal , Scharinger Andreas , Richling Elke , Walch Stephan G. , Lachenmeier Dirk W.
Published: July 2022

Background: In the past 60 years, Cannabis sativa L. has been an object of increasing interest because of the psychotropic effects of some of its constituents. These effects mainly arise from the cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC). C. sativa species also synthesize and accumulate the non-psychotropic compound cannabidiol (CBD). Due to their therapeutic potential, both cannabinoids are an object of medical research and drug development. More recently, CBD has received increasing interest as an ingredient in electronic cigarette liquids (e-liquids). This trend may have been reinforced by health and disease-related claims, often based on clinical studies, which are used to advertise CBD. CBD liquids may be based on full-spectrum hemp extracts, CBD isolates, or synthetic CBD, all of which may contain some residual levels of Δ9-THC from either natural content (in the extracts) or from possible degradation of CBD to Δ9-THC, which may occur during storage. There is uncertainty about safety regarding the consumption of CBD (and Δ9-THC) in e-liquids. The aim of this publication was to present an approach for a toxicological risk assessment of CBD and Δ9-THC relevant to e-liquids by using the benchmark dose (BMD) approach. Materials and Methods: Before an analysis to estimate a reference dose (RfD) for both cannabinoids, a systematic review of dose-response data was conducted. The data obtained were analyzed using the BMD approach to derive a benchmark dose lower confidence limit (BMDL). The BMDL was used as a point of departure to estimate the RfD. Results: No adequate human data suitable for dose-response modeling were identified. Based on animal data, the RfD values for the most sensitive endpoints were selected. For CBD, an RfD for acute exposure of 1 mg/kg body weight (bw) was estimated. For Δ9-THC, an acute RfD was found to be 0.006 mg/kg bw. Additionally, the RfD for chronic exposure to CBD was estimated to be 4 mg/kg bw per day. The respective endpoints for CBD were a reduction in norepinephrine turnover and a reduction in uterus weight. The endpoint for Δ9-THC was a change in blood pressure. Conclusions: Because of the limited availability and quality of dose-response data, it cannot be excluded that the estimated RfD values might be afflicted with considerable uncertainties. Therefore, it is recommended to conduct further research on dose-response data, preferably from human studies.
Current Trends of Computational Tools in Geriatric Medicine and Frailty Management
Authors: Louka Anna Maria , Tsagkaris Christos , Christoforou Panagiotis , Khan Andleeb , Alexiou Filia , Simou Panagiota , Haranas Ioannis , Gkigkitzis Ioannis , Zouganelis Georgios , Jha Niraj Kumar , Uddin Md Sahab , Shen Bairong , Kamal Mohammad A. , Ashraf Ghulam Md , Alexiou Athanasios
Published: July 2022

While frailty corresponds to a multisystem failure, geriatric assessment can recognize multiple pathophysiological lesions and age changes. Up to now, a few frailty indexes have been introduced, presenting definitions of psychological problems, dysregulations in nutritional intake, behavioral abnormalities, and daily functions, genetic, environmental, and cardiovascular comorbidities. The geriatric evaluation includes a vast range of health professionals; therefore, we describe a broad range of applications and frailty scales-biomarkers to investigate and formulate the relationship between frailty lesions, diagnosis, monitoring, and treatment. Additionally, artificial intelligence applications and computational tools are presented, targeting a more efficacy individualized geriatric management of healthy aging.
Repetitive Transcranial Magnetic Stimulation Decreases Serum Amyloid-β and Increases Ectodomain of p75 Neurotrophin Receptor in Patients with Alzheimer’s Disease
Authors: Tao Yong , Lei Bin , Zhu Yang , Fang Xiangqin , Liao Lingyi , Chen Dongwan , Gao Changyue
Published: July 2022

Background: This study investigated the impact of repetitive transcranial magnetic stimulation (rTMS) on serum levels of Amyloid-β (Aβ) as well as the ectodomain of p75 neurotrophin receptor (p75ECD) in patients with Alzheimer’s disease (AD). Methods: A total of 46 patients diagnosed with AD between June 1, 2020 and December 31, 2021 were randomized to undergo either 20 Hz rTMS treatment of the left dorsolateral prefrontal cortex (DLPFC) or sham procedure. Cognitive function and activity of daily living were evaluated. Neuropsychological tests and blood samples were gathered at baseline and at 2, 3, 4, and 6 weeks after rTMS therapy. Results: There were no evident differences between rTMS group and sham group in serum Aβ40, Aβ42, total Aβ, ApoE, and p75ECD standards at baseline (p > 0.05). Serum levels of Aβ40, Aβ42, as well as total Aβ, were significantly lower in the rTMS group at 3, 4 and 6 weeks relative to the sham group (p < 0.05). Serum p75ECD levels in the rTMS group were significantly higher than those of the sham group at 3, 4 and 6 weeks (p < 0.05). Levels of serum Aβ40 (r: –0.78, –0.83, –0.68, respectively), Aβ42 (r: –0.76, –0.76, –0.61, respectively) and total Aβ (r: –0.74, –0.81, –0.66, respectively) were negatively correlated with MoCA, MMSE and MBI scores, while serum p75ECD levels (r: 0.84, 0.90, 0.72, respectively) were positively correlated (p < 0.01). The level of serum Aβ40 (r = 0.77), Aβ42 (r = 0.69) as well as total Aβ (r = 0.73) were positively correlated with ADAS-cog score, while p75ECD levels (r = –0.86) were negatively correlated (p < 0.01). Conclusions: The results of this study suggest that rTMS may decrease serum Aβ levels and increase serum p75ECD levels in patients with AD, offering insight into a potential underpinning mechanism of rTMS.
Anti-Müllerian Hormone and Cardiometabolic Disease in Women: A Two-Sample Mendelian Randomization Study
Authors: Verdiesen Renée M.G. , von Berg Joanna , Said M. Abdullah , van der Harst Pim , Mahajan Anubha , van Gils Carla H. , van der Schouw Yvonne T. , Onland-Moret N. Charlotte
Published: July 2022

Background: Higher age-specific circulating anti-Müllerian hormone (AMH) levels have been linked to a lower risk of cardiometabolic outcomes. However, whether AMH has a casual role in the etiology of these diseases is unknown. The objective of this study was therefore to explore if circulating AMH levels have a causal effect on risk of coronary artery disease (CAD), ischemic stroke and type 2 diabetes (T2D) in women, using a two-sample Mendelian randomization (MR) approach. Methods: We used four single nucleotide polymorphisms (SNPs) from the most recent AMH GWAS meta-analysis as instrumental variables. Summary-level data for CAD (n = 149,752; 11,802 cases), ischemic stroke (n = 17,541; 4678 cases) and T2D (n = 464,389; 30,052 cases) were extracted from the UK Biobank, the Stroke Genetics Network, and DIAMANTE consortia, respectively. To assess the presence of potential pleiotropy we tested the association of the four AMH SNPs, both individually and combined in a weighted genetic risk score, with a range of cardiovascular risk factors and intermediate traits using UK Biobank data. Results: MR estimates, i.e., inverse variance-weighted odds ratios (ORIVW), did not support a causal effect of circulating AMH levels on CAD (ORIVW = 1.13, 95% CI: 0.95–1.35), ischemic stroke (ORIVW = 1.11, 95% CI: 0.83–1.49), and T2D (ORIVW = 0.98, 95% CI: 0.87–1.10). After adjustment for multiple testing, we observed associations between genetically predicted AMH and age at menopause, and age at menarche, but not with intermediate traits on the causal pathway between AMH and cardiometabolic health, such as atherosclerosis or glucose levels. Conclusions: This study does not provide evidence for a causal effect of circulating AMH levels on CAD, ischemic stroke and T2D in women, although weak instrument bias cannot be excluded.
Lipid Profile and Atrial Fibrillation: Is There Any Link?
Authors: Jiang Qi , Yang Ling , Chen Ming-Long , Hua Fei , Li Jian-Jun
Published: July 2022

Atrial fibrillation (AF) is the most common type of symptomatic arrhythmias, which was induced by multiple causes and dyslipidemia is a well-known causal factor for the atherosclerotic cardiovascular disease (ASCVD). Interestingly, emerging data has suggested that lipid disorder may be also associated with AF. Several previous studies have shown a link of the prevalence of AF with decreased concentration of low-density lipoproteins (LDL)-cholesterol, total cholesterol (TC), high-density lipoproteins (HDL)-cholesterol, and elevated lipoprotein(a) [Lp(a)]. In this manuscript, we try to summarize the current evidence regarding the relation of dyslipidemia to the incident AF, present the potential lipid-related mechanisms of AF development, which is involved in cell membrane properties, LDL-receptors reduction, reverse cholesterol transport, adiposity-induced inflammation, apoptosis, and autophagy. Such information may boost our understandings concerning the lipid disorder and AF, which may help future exploration in the link of dyslipidemia and AF.
Exercise Stress Echocardiography for Stable Coronary Artery Disease: Succumbed to the Modern Conceptual Revolution or Still Alive and Kicking?
Authors: Barbieri Andrea , Bursi Francesca , Santangelo Gloria , Mantovani Francesca
Published: July 2022

The modern conceptual revolution in managing patients with stable coronary artery disease (CAD), based on improvement in preventive and pharmacological therapy, advocates coronary artery revascularization only for smaller group of patients with refractory angina, poor left ventricular systolic function, or high-risk coronary anatomy. Therefore, our conventional wisdom about stress testing must be questioned within this new and revolutionary paradigm. Exercise stress echocardiography (ESE) is still a well-known technique for assessing known or suspected stable CAD, it is safe, accessible, and well-tolerated, and there is an widespread evidence base. ESE has been remarkably resilient throughout years of innovation in noninvasive cardiology. Its value is not to be determined over the short portion of diagnostic accuracy but mainly through its prognostic value evident in a wide range of patient subsets. It is coming very close to the modern profile of a leading test that should include, in addition to an essential accettable diagnostic and prognostic accuracy, qualities of low cost, no radiation exposure, and minor environmental traces. In this review, we will discuss advantages, diagnostic accuracy, prognostic value in general and special populations, cost-effectiveness, and changes in referral patterns of ESE in the modern era.
Generation X Consumption Behavior Model in Using Digital Transactions
Authors: Sirait Afni , Purnama Ida Ayu
Published: July 2022

Technology is a necessity that cannot be separated from today's life. Daily activities become easier, even ignoring distance, space, and time. This convenience provides cost savings, improves the use of time, and even changes business processes. This study aims to analyze the model of consumer behavior of generation X in the use of digital transactions. This research is quantitative research with 73 respondents who meet the qualifications. Data was collected using a questionnaire which was then tested for validity, reliability, and model fit using the WarpPLS 6.0 analysis tool. The results of data processing and testing are carried out; it can be concluded that first, cultural factors mediated by consumption behavior do not directly affect generation X in digital transactions. Second, psychological factors have a direct influence on generation X digital transactions. Consumption behavior as a mediating variable does not have an influence between psychological factors and digital transaction behavior for generation X. The limitation of this study is that the population only focuses on generation X.
Digital Marketing Through Instagram Ads: A Case Study of “Instaboost Life” Instagram
Authors: Sugeng Ayu Sulistya Putri , Chusjairi Juni Alfiah
Published: July 2022

This study concerns a small medium enterprise called “ Instaboost Life”. Instaboost Life is an online shop that sells healthy products such as slimming tea, beverages for mothers who are breastfeeding, lemon beverages, and other healthy beverages that are healthy and safe for diet. Due to their high price, the products are highly likely to be consumed by middle-class people. As an online shop, the products are merely for sale online. Therefore, social media is used to promote the products, which in this case is Instagram. The aim of this research is to identify whether more advertising on Instagram raises more potential buyers and finally make a purchase decision. The data collected in this research is internal data from Instaboost Life from January-June 2021 and 5 interviews with users of Instaboost Life. After analyzing the data, the authors conclude that more budget spending plays a significant role in reaching the targeted audience and potential buyers. Furthermore, their decision to purchase order. In addition, the interviewees also confirmed that advertising played a significant role in their decision to purchase order products from Instaboost Life.
Stigmatization of Former Corruption Convicts in Indonesian Parliament Elections
Authors: Tampubolon Manotar , Siahaan Chontina
Published: July 2022

This article examines the social stigma of defunct corruption convicted criminals in Indonesia's parliament elections using the stigma concept and human rights. This research is a socio-legal cogitate which disfigures the challenges of the electoral social stigma of peoples' political freedoms whenever one wants to pursue just after elections and be appointed through lawful means. Every Indonesian citizen may cast a ballot and be selected, which is granted and protected by the law. However, in most cases, such sheltered rights are limited once former prisoners from Indonesia run for positions in the council or legislature. The primary squeezing address is why the state should restrict prior devaluation of prisoners' capacity to run for parliamentary office whereas ensuring that each citizen's political rights are fully protected within the framework. The explanation for this may be that the national legislature is among the most fraudulent institutions in the country. Under the worst circumstance, former corruption convicts would be ostracized and will perpetuate a punishable offense after already being voted into power by a house of representatives. This paper proves the electoral demonization of a state as just a set of criteria for parliaments nominees.