bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of multistage immunotherapy to achieve remission before haploidentical hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia and the treatment of complications of this therapy in the early post-transplant period: a review of the literature and a clinical case
Authors: Sergeenko K. A. , Aliev T. Z. , Kostareva I. O. , Lozovan Yu. V. , Malova M. D. , Batmanova N. A. , Valiev T. T. , Machneva E. B. , Kirgizov K. I.
Published: August 2022

Despite improved understanding of the biology of the disease and the use of multicomponent chemotherapy, the prognosis for children with relapsed or refractory B-line acute lymphoblastic leukemia (B-ALL) remains poor. Currently, the only definitive treatment for these patients is allogeneic hematopoietic stem cell transplantation (allo-HSCT), which can be performed after achieving immunohematological remission. Conducting highintensity polychemotherapy (PCT) blocks to achieve negative values of minimal residual disease (MRD) is often limited due to high toxicity. The developed monoclonal antibodies targeting cell surface antigens, such as CD19 and CD20, are actively used in children with relapsed/refractory B-ALL as part of “bridge therapy”, which allows achieving MRD-negative status without the use of intensive chemotherapy. However, new strategies are needed to improve the prognosis of these patients. The drug Inotuzumab ozogamicin has demonstrated efficacy in relapses of B-ALL and is actively used to achieve a negative MRD status before the allo-HSCT stage in children. In the presented article, in addition to a brief review of the literature, clinical experience with the use of this drug is demonstrated.
Exploring the Molecular Aspects of Glycosylation in MOG Antibody
Disease (MOGAD)
Authors: Lakshmi Narasimhan Ramya , Sharma Gayathri , Gopinath Smrithi
Published: August 2022

Myelin Oligodendrocyte Glycoprotein-antibody disease (MOGAD) is an immune-mediated disorder that mainly targets the central nervous system of the patient. The pattern of inflammation caused by MOGAD mainly targets the brain stem, spinal cord, and optic nerve, and the symptoms vary from person to person. Its clinical features often overlap with Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorder (NMOSD) which makes the accurate diagnosis of this rare neurodegenerative disease quite difficult. Hence, this review was attempted not only to understand MOGAD but also to comprehend the differences between MOGAD and MS with the help of a brief overview of the similarities and contrasting features. Here we highlight the mechanism and importance of MOG in myelination and demyelination. Glycosylation has a serious impact on the myelination of neurons as N-glycan helps in the proper folding of MOG. On transforming into an autoantigen, MOG can activate the classical complement pathway by triggering the activation of proteins associated with the complement cascade. Patients with persistently positive antibodies to MOG are at risk for recurrent episodes of MOGAD. In the current scenario, there is an urgent need to develop therapeutic interventions that induce remyelination. Remyelination in terms of MOG glycosylation is hypothesized as a possible strategy to treat patients diagnosed with MOGAD. On the whole, the article aims to provide a clear insight into the disease and the structural aspects associated with it.
First-in-human Study to Evaluate a Single Injection of KiOmedine®CM-Chitosan for Treating Symptomatic Knee Osteoarthritis
Authors: Emans P.J. , Skaliczki G. , Haverkamp D. , Bentin J. , Chausson M. , Schifflers M. , Hermitte L. , Douette P.
Published: August 2022

Background:

Single-injection viscosupplementation is currently performed with cross-linked hyaluronan (e.g., Durolane®) for treating symptomatic knee osteoarthritis.

Objective:

This first-in-human study evaluated the safety and performance of single-injection treatment with non-crosslinked KiOmedine®CM-Chitosan.

Methods:

Patients with painful knee osteoarthritis were randomly assigned to the KiOmedine®CM-Chitosan (n=63) or Durolane® (n=32) group. Patients were blinded to treatment and followed up for 26 weeks. Durolane® was used as scientific control to ensure the validity of the study and reliability of results. No direct comparison was performed between the two groups. The primary objective was defined as an intra-group effect size of 0.8 at 13 weeks post-injection compared to baseline on WOMAC-A (pain). Secondary outcomes included self-reported knee stiffness and knee function, responder rate, quality-of-life questionnaires, and safety.

Results:

The primary objective for both the KiOmedine®CM-Chitosan and the Durolane® groups was met: mean pain reduction of 62.5% (effect size 2.08) for the KiOmedine®CM-Chitosan group and 62.4% (effect size 2.28) for the Durolane® group. Secondary performance outcomes showed all clinically relevant treatment effects over 26 weeks for both groups (p<0.05). Treatment-related adverse events were more often reported in the KiOmedine®CM-Chitosan than Durolane® group and were limited to local reactions. No serious treatment-related adverse events were reported.

Conclusion:

A single intra-articular injection of non-crosslinked KiOmedine®CM-Chitosan is safe and effective for treating symptomatic knee osteoarthritis with a high responder rate. Pain reduction is maintained for 6 months with a high responder rate.

The clinical trial registration number: NCT03679208.
Isolation, Characterization of Banana Starch and its Evaluation as a
Disintegrating Agent in Dispersible Lornoxicam Tablet
Authors: Puri Abhijeet V. , Gokhale Vrushali N.
Published: August 2022

Objective:

The present study was designed to isolate, characterize, formulate, and evaluate the disintegration properties of banana starch in dispersible Lornoxicam tablet formulation.

Methods:

The alkaline extraction method used sodium hydroxide as a lye solution to isolate starch from unripe banana fruit. Starch was subjected to characterization for physicochemical properties, viscosity and flow properties, Fourier-transform infrared spectroscopy (FTIR) scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray crystallography (XRD) study. Flow properties of starch were determined as per the standard procedure. Tablets were formulated by a wet granulation method using starch as a disintegrant, and the in-vitro release characteristic of the prepared tablets was analyzed. Different concentrations of isolated starch were studied for disintegrating properties compared to corn starch.

Results:

Studies indicate that starch obtained is qualitatively and quantitatively comparable to corn starch. SEM, FTIR, DSC and XRD data confirmed the polysaccharide nature of the starch. The physicochemical properties of starch passed the prescribed evaluation tests for tablets. These tablets also confirmed the disintegration and dissolution specifications as per Indian Pharmacopoeia.

Conclusion:

From the above study, it can be concluded that starch obtained from banana shows qualitatively and quantitatively good disintegration characteristics compared to corn starch. These tablets also confirmed a significant degree of dissolution as per the standards. Evaluations also specified that banana starch possesses acceptable disintegrating characteristics compared to corn starch and can be used as a disintegrant in tablet formulation.
Role of Biomarkers in Rheumatoid Arthritis
Authors: Malhotra Hitesh , Kamboj Anjoo
Published: August 2022

Rheumatoid arthritis is a chronic inflammatory condition that mainly affects
the joint due to hyperactive immune reactions. The disease involves each component of
the joint tissue with varying degrees of inflammation and destruction. The basic
pathogenesis includes two key points, i.e., hyperactive immune reaction and
inflammation. The phenomenon is driven by biomolecules which form a complex
pathophysiological network, resulting in disease development and progression. The
biomolecules like cytokines, such as interleukins, tumor necrosis factor-alpha, and
interferon, play a fundamental role in joint and cartilage destruction, production of
destructive enzymes, inflammatory reaction, and comorbidities related to the disease.
From various pre-clinical and clinical researches, various attributes of disease
development and progression can be demonstrated by focusing on the biological
contribution of mediators, like IL-1, TNF- α, IL-6, IL-15, IL-17, and IL-18. Numerous
reports confer the successful treatment of RA that might be possible by blocking the
activity of these biomarkers. In this chapter, we discuss the role of biomolecules in the
pathology of arthritis.
Inflammatory Mediators and Cytokines involved in Rheumatoid Arthritis
Authors: Sharma Vikash , Shankar Shukla Shiv , Vyas Amber , Kumar Pandey Ravindra
Published: August 2022

Rheumatoid arthritis (RA) is a chronic inflammatory disease that mostly
affects the joints. Inflammation is an immune response of the human body, but an
overabundance of such responses is thought to be a key element in the evolution of
many other issues, including RA, cancer, and neurological illnesses. The growth and
inhibition of RA necessitate the identification of a precise mechanism and target in the
body. Interleukins (IL), tumour necrosis factors (TNF-), interferons (INF), and
arachidonic acid derivatives are the most important cytokines and inflammatory
mediators in rheumatoid arthritis. IL-6 inhibitors, JAK inhibitors, anti-TNF, and
currently available disease-modifying anti-rheumatic medications (DMARDs) have all
been demonstrated to be effective in the treatment of RA. We have also summarised
the inflammatory mediators such as arachidonic acid metabolites and their role in
inflammation. This chapter also observed cytokines and other transcription factors that
play a role in the disease's onset and progression. The current study includes a wide
range of issues, including RA molecular pharmacology, such as cytokines
pharmacology, transcription factors, and other active biomolecules. However, the study
shows that a number of biomolecules and mediators play a key role in the pathogenesis
of RA, and a thorough understanding of the underlying pathways can aid in the creation
of new targeted pharmacological therapies that are both safer and more effective in RA
Natural Products Targeting Various Mediators in Rheumatoid Arthritis
Authors: Arora Disha , Sharma Sanjay , Gupta Sumeet
Published: August 2022

Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to an
inflammatory reaction, primarily affecting synovial joints and progressive cartilage and
bone destruction resulting in gradual joint immobility. Possibly, a diversity of
pharmacological intercessions are employed for treating arthritis. But modern treatment
is linked with serious adverse outcomes and high expenses. Therefore, alternative
therapies have been under examination. Scientific facts on RA have revealed that
conventional therapy offers a favourable impact by various actions (cellular) like
repression of oxidative stress, down-regulation of pro-inflammatory cytokines, such as
IL-6, NF-ƙB, and TNF-α, and inhibiting cartilage degradation. A wide range of active
phytoconstituents from the medicinal plants, such as terpenes, anthraquinones,
glycosylflavons, flavonols, dihydroflavonols, lignans, coumarins, phytoestrogens,
sesquiterpene lactones, thymoquinone, and alkaloids reduced the arthritic
manifestations through selecting the pro-inflammatory indicators, which play a role in
the pathogeny of the disease (RA). With numerous developments in the last few years
regarding functional studies or characterization of plant materials, the phase is put
down for extensive scientific trials or using the plants or their products to manage
rheumatoid arthritis. The chapter discusses the plants used conventionally with
phytoconstituents having anti-inflammatory action. This, in turn, leads to the
innovation of new benefits from natural products in the future.
Potential Biomolecules from the Natural Sources for the Treatment of Rheumatoid Arthritis: A Detailed Review
Authors: Samanta Ajeya , Bhattacharya Dhruba , Mazumder Kamalika , Kumar Jain Shreyans , Biswas Kaushik
Published: August 2022

Rheumatoid arthritis is a disease of the immune system where pro.inflammatory mediators produce inflammation, swelling, and pain in joints and
muscles. Continuous progression may cause damage to articular cartilages, joint tissue,
and decaying of bones, which may ultimately lead to disability or mortality. Prevention
of the progression of rheumatoid arthritis is a severe challenge for the medical system
and scientific community. The present pharmaceutical intervention comprises
NSAIDS, steroids, and disease-modifying anti-arthritic drugs (DMARDs). Medical
interventions, like surgery and knee replacement, are also available. These synthetic
drugs are accompanied by several adverse effects ranging from acute to chronic ones.
The use of natural products is an important alternative for the treatment of rheumatoid
arthritis. Plants, microbes, and other natural sources involve vital bioactive molecules,
which are being employed in the treatment of several diseases. Plant-derived bioactive
molecules, like boswellic acid, acetyl-β-boswellic acid, guggulsterone, curcuminoids,
etc., are promising components, serving as a therapy for rheumatoid arthritis. These
bioactive molecules have been evaluated for their effects on rheumatoid arthritis using
different screening methods, and they have shown prospective results. Many plant
extracts have been used to halt the disease progression, and promising results have
been recorded. Bioactive molecules produced by microorganisms are potential
candidates to be used in rheumatoid arthritis, and few microorganisms could be used
directly as probiotics to combat the altered immune system. These microbes secrete
numerous chemicals into the gut of the host, which are responsible for inhibiting the
pro-inflammatory mediators, and helping to prevent the disease.
HIGH-INTENSITY OF GADGET USE INCREASES “CAUTIONS” TOWARD PRESCHOOL CHILDREN DEVELOPMENT
Authors:   Brawijaya University, Sari Ningrum Paramita , Silvani Yulia ,   Brawijaya University, Ulfah Mega ,   Brawijaya University, Sari Sandra Dwi Puspita ,   Brawijaya University
Published: August 2022

Development is an ongoing process and related to functional matters. One of the factors influencing development is the environment. Excessive and uncontrolled use of gadgets can adversely affect children's motor development, social abilities and communication. This study aims to analyze the relationship between the intensity of gadget use to social personal development, fine motor, gross motor and language in preschool age children (3-6 years). The study subjects were 135 children aged 36 to 72 months. Sampling is done by Purposive Sampling technique. Data retrieval using Denver II Sheet (which has been adapted for use in Indonesia) for early detection examination of child developmental disorders. The results of the study obtained the type of gadgets used by children: 82.5% smartphones, 4.4% tablets, 5.2% smartphones and tablets, 5.2% smartphones and laptops. Based on the type of application used: 8.1% learn (reading, writing, etc.), 35.6% video, 45.9% games and 10.9% puzzles. Meanwhile the intensity of gadget use in preschoolers was obtained 27.4% low intensity, 32.6% medium intensity and 40.0% children using gadgets with high intensity. Chi-square test results showed social personal development p 0.000; fine motor p 0.001; gross motor p 0.069 and language p 0.000.The conclusion of this study is the intensity of gadget use related to the development of social personal, fine motor and language in preschool children (36-72 months).
FAMILIA GRAMINEAE: SUBFAMILIA POÖIDEAE
Authors:   Herbario de la Facultad de Ciencias, Universidad Nacional Autónoma de México, Martínez-Ambriz Emmanuel
Published: August 2022

La familia Loranthaceae agrupa alrededor de 1000 especies y 73 géneros alrededor del mundo, por lo que es considerada uno de los grupos de plantas parásitas más diversos. La mayoría de sus especies se distribuyen principalmente en las zonas tropicales y subtropicales del Viejo y Nuevo Mundo, aunque también pueden encontrarse en regiones templadas. Se distinguen del resto de las familias de plantas parásitas por sus hojas generalmente opuestas a subopuestas, con venación usualmente inconspicua, flores epíginas, más o menos tubulares, usualmente pentámeras o hexámeras y corolas en su mayoría en diversas tonalidades de rojo, anaranjado o amarillo. Para la región de estudio se registran tres géneros: Cladocolea con tres especies, Psittacanthus con cinco y Struthanthus con tres.
Investigating a Work System Approach to Implement an Emergency Department Surge Management System: Case Study
Authors: Jewer Jennifer
Published: August 2022

Background

Emergency department (ED) crowding is a global health care issue. eHealth systems have the potential to reduce crowding; however, the true benefits are seldom realized because the systems are not integrated into clinicians’ work. We sought a deep understanding of how an eHealth system implementation can be structured to truly integrate the system into the workflow.

Objective

The specific objectives of this study were to examine whether work system theory (WST) is a good approach to structure the implementation of an eHealth system by incorporating the entire work system, and not just the eHealth system, in the implementation framework; identify the role that specific elements of WST’s static framework and dynamic work system life cycle model play in the implementation; and demonstrate how WST can be applied in the health care setting to guide the implementation of an eHealth system.

Methods

Through a case study of an ED in a rural hospital, we used a mixed methods approach to examine the implementation of a surge management system through the lens of WST. We conducted 14 hours of observation in the ED; 20 interviews with clinicians, management, and members of the implementation team; and a survey of 23 clinicians; reviewed related documentation; and analyzed ED data to measure wait times. We used template analysis based on WST to structure our analysis of qualitative data and descriptive statistics for quantitative data.

Results

The surge management system helped to reduce crowding in the ED, staff was satisfied with the implementation, and wait time improvements have been maintained for several years. Although study participants indicated changes to their workflow, 72% (13/18) of survey participants were satisfied with their use of the system, and 82% (14/17) indicated that it was integrated with their workflow. Examining the implementation through the lens of WST enabled us to identify the aspects of the implementation that made it so successful. By applying the WST static framework, we saw how the implementation team incorporated the elements of the ED work system, assessed their alignment, and designed interventions to address areas of misalignment. The dynamic work system life cycle model captured how planned and unplanned changes were managed throughout the iterative implementation cycle—83% (15/18) of participants indicated that there was sufficient management support for the changes and 80% (16/20) indicated the change served an important purpose.

Conclusions

The broad scope and holistic approach of WST is well suited to guide eHealth system implementations as it focuses efforts on the entire work system and not just the IT artifact. We broaden the focus of WST by applying it to the implementation of an ED surge management system. These findings will guide further studies and implementations of eHealth systems using WST.
Memperkuat Ketahanan Masyarakat Berbasis Social Capital Pada Era Otonomi Desa (Studi Di Desa Pandansari, Kecamatan Ngantang, Kabupaten Malang)
Authors: Rozikin Mochammad
Published: August 2022

ABSTRACTThe 1997 reforms brought changes in regional governance from a centralized model to decentralization. The village autonomy Law number 6 year 2014 was showed a new era where the existence of villages was appreciated as the smallest unit of government system in Indonesia, with all its diversity as local wisdom to strengthened community resilience nationally starting from the village. This study used descriptive qualitative method, with the analysis step according to Bogdan and Biklen (1982), carried out 2 (two), namely the first stage of data analysis during the field and second analysis of data after collected. The research location of Pandansari village, Ngantang District, Malang Regency, was affected by the Mount Kelud eruption which affected the resilience of rural communities. Data was taken by interview techniques, observations and supporting documents. The results of the study showed that after the impact of the Mount Kelud disaster the resilience of the community was quite disturbed, but it could return to normal with the efforts to developed resilience of rural communities by integrating social capital that existed in the community. Thus, Social capital that developed in the community contributed to developed community resilience after natural disasters.ABSTRAKReformasi tahun 1997 membawa  perubahan tatakelola pemerintahan daerah dari model sentralisasi kepada desentralisasi. Kemudian dalam otonomi desa terbit Undang-Undang nomor 6 tahun 2014. Hal ini menunjukkan era baru dimana keberadaan desa diapresiasi sebagai unit terkecil system pemerintahan di Indonesia, dengan segala keragamannya sebagai kearifan lokal, untuk memperkuat ketahanan masyarakat secara nasional yang dimulai dari desa.Penelitian ini menggunakan metode diskriptif kualitatif , dengan langkah analisis menurut Bogdan dan Biklen (1982), dilakukan 2 (dua) yaitu  tahap pertama analisis data selama di lapangan dan kedua analisis data setelah terkumpul. Lokasi penelitian Desa Pandansari, Kecamatan Ngantang, Kabupaten Malang, yang terkena dampak bencana letusan Gunung Kelud yang berpengaruh terhadap ketahanan masyarakat desa. Data diambil dengan teknik wawancara, observasi dan dokumen pendukung.Hasil penelitian menunjukkan pasca dampak bencana Gunung Kelud ketahanan masyarakat cukup terganggu, tetapi dapat kembali normal dengan adanya upaya pengembangan ketahanan masyarakat desa dengan mengintegrasikan modal sosial (social capital) yang ada pada masyarakat. Modal sosial yang berkembang pada masyarakat memberikan kontribusi dalam mengembangkan ketahanan masyarakat pasca bencana alam.
A Comparative Study of Developmental Mathematics Pass Rates for Two Student Groups: Emporium Classes and Traditional Lecture-based Classes
Authors: Wang David
Published: August 2022

Since the turn of the 21st century, the emporium model has become a popular choice for colleges and universities to reform developmental mathematics. The purpose of this study is to determine overall how successful Northeast Metro College (NMC)’s emporium developmental mathematics program is as compared to its traditional lecture-based program by comparing these two programs’ student pass rates in developmental courses. This research is a non-experimental, secondary data quantitative analysis study with nonrandom convenience samples. The findings indicate that generally emporium classes prepare students for passing developmental mathematics more successfully than traditional lecture-based classes do.
Lie (Jordan) centralizers on alternative algebras
Authors: Jabeen Aisha , Ferreira Bruno L. M.
Published: August 2022

In this article, we study Lie (Jordan) centralizers on alternative algebras and prove that every multiplicative Lie centralizer has proper form on alternative algebras under certain assumptions.
Spectral analysis for finite rank perturbation of diagonal operator in non-archimedean Banach space of countable type
Authors: El Amrani Abdelkhalek , Blali Aziz , Taybi Mohamed Amine
Published: August 2022

In this paper we are concerned with the spectral analysis for the classes of finte rank perturbations of diagonal operators in the form A = D+F where D is a diagonal operator and F = u’1 ⊗v’1+...+u’m ⊗vm is an operator of finite rank in the non-archimedean Banach space of countable type. We compute the spectrum of A using the theory of Fredholm operators in non archimedean setting and the concept of essential spectrum for linear operators.
Caminos culturales mesoamericanos. Obras completas de Otto Schumann Gálvez. Volumen 1. Artículos y ensayos
Authors:   CIMSUR-UNAM
Published: August 2022

En este primer volumen se ofrece al lector la recopilación de 42 artículos publicados por el autor en diversos libros y revistas nacionales y extranjeras. Los textos aquí reunidos ponen de manifiesto su especial interés por el estudio de las lenguas mayas, área en la que sin duda constituyó un referente ineludible durante su trayectoria profesional.
Diversidad cultural y patriotismo en los libros escolares de Centroamérica
Authors:   CIMSUR-UNAM, Ascencio Franco Gabriel
Published: August 2022

Este volumen busca esclarecer la naturaleza del tratamiento de la diversidad cultural, religiosa, étnica y nacional de los manuales escolares de ciencias sociales de los países de Centroamérica, muestra el contraste entre la imposición de una identidad dominada frente a la promoción de las identidades propias con el fin de apuntalar el aprecio y respeto por la diversidad.
Vivir sufriendo de azúcar. Representaciones sociales sobre la diabetes mellitus en tres localidades de los Altos de Chiapas
Authors:   CIMSUR-UNAM, Page Pliego Jaime Tomás , Eroza Solana Enrique , Acero Vidal Cecilia Guadalupe
Published: August 2022

El estudio que da contenido al presente volumen se inscribe en el interés y posicionamiento de la antropología médica crítica por investigar y resaltar los problemas del proceso salud/enfermedad/atención-prevención que fustigan en especial a los grupos marginados y excluidos de nuestras sociedades.
Fútbol en Cuba. Entre el balón y "la pelota" en la comunidad global
Authors:   CIMSUR-UNAM, Lisbona Guillén Miguel
Published: August 2022

El fútbol como fenómeno global está presente en la Mayor de las Antillas, aunque históricamente, y en especial tras la Revolución cubana, el béisbol se convirtió en el deporte vinculado a la representación nacional. Hoy, sin embargo, existen aficionados que vivifican el interés por el fútbol internacional sin romper con la identidad nacional cubana, e incluso hay grupos que se esfuerzan por el crecimiento competitivo de su seleccionado en el concierto mundial. Ello no significa que sean partícipes de representaciones simbólicas estáticas y homogéneas, ilustradas por la cubanidad institucionalizada. En consecuencia, una disciplina deportiva como el fútbol muestra conexiones transnacionales en Cuba, y se convierte en un ejemplo y motor de transformaciones, desde las vinculadas al consumo y a las novedades tecnológicas, hasta las que replantean certezas ideológicas e identificaciones sociales.
Social embeddedness and agricultural technology diffusion from the perspective of scale differentiation – a case study from China
Authors: Li Kai , Li Qi
Published: August 2022

Social embeddedness always plays important role in facilitating agricultural technology diffusion. However, in China, dramatic changes have occurred in the social embeddedness of rural households in the transition from ‘acquaintance society’ to ‘semi-acquaintance society’. Could this be the reason for the debate over the role of social embeddedness? What are the differences in the role of social embeddedness between farmers with different land scales? Based on survey data from 583 rural households from Zhejiang Province, China, we used an endogenous switching regression model to answer these questions. The results indicated there are significant differences in social embeddedness between large- and small-scale households. Although the influence of social embeddedness on technology adoption remains significant, its function is significantly different between small- and large-scale farmers. To avoid technological lock-in for small-scale farmers, the government should strengthen the information push and expand the coverage of environmental-friendly agricultural subsidies for them.
International Multicenter Registry for Hyperbaric Oxygen Therapy: Results through June 2021
Authors:   Dartmouth-Hitchcock Medical Center, Lebanon, NH, US, Harlan Nicole P , Ptak Judy A ,   Independent Consultant, Plainfield, NH, US, Rees Judy R ,   Geisel School of Medicine at Dartmouth, Lebanon, NH, US, Cowan Devin R. ,   Geisel School of Medicine at Dartmouth, Lebanon, NH, US, Fellows Abigail M ,   Geisel School of Medicine at Dartmouth, Lebanon, NH, US, Moses Rachel A ,   Dartmouth-Hitchcock Medical Center, Lebanon, NH, US, Kertis Judith A ,   Dartmouth-Hitchcock Medical Center, Lebanon, NH, US, Hannigan Pamela M ,   Dartmouth-Hitchcock Medical Center, Lebanon, NH, US, Juggan Saeed A ,   Dartmouth College, Hanover, NH, US, Peacock Janel ,   Geisel School of Medicine at Dartmouth, Lebanon, NH, US,   King’s College, London, UK, Bennett Michael ,   Prince of Wales, Hospital, Randwick, NSW, Australia, Buckey Jay ,   Geisel School of Medicine at Dartmouth, Lebanon, NH, US,   Multicenter Registry for Hyperbaric Oxygen Therapy Consortium
Published: August 2022

Introduction: The International Multicenter Registry for Hyperbaric Oxygen Therapy (International Report Registered Identifier DERR1-10.2196/18857) was established in 2011 to capture outcomes and complications data for both Undersea and Hyperbaric Medical Society (UHMS) approved and selected unapproved hyperbaric oxygen (HBO2) therapy indications. Methods: A Research Electronic Data Capture (REDCap) template was designed and distributed to all participating centers for prospective data collection. Centers contributed de-identified demographic, treatment, complications, and outcome data. This report provides summary data on sites and enrollment, as well as pre- and post-treatment data on quality of life (EQ-5D-5L questionnaire), head and neck radiation outcomes, non-healing wounds (Strauss score), and idiopathic sudden sensorineural hearing loss. Data were analyzed mainly using the Wilcoxon signed-rank test. Results: Twenty-two centers contributed data for 2,880 patients. The most common UHMS-approved indication was delayed radiation injury, followed by enhancement of wound healing, and carbon monoxide poisoning. One hundred and twenty-five patients were treated for non-UHMS approved indications. Quality of life, head and neck radiation symptoms, Strauss wound scores, and hearing were significantly improved after HBO2. Complication rates were low and comparable to previous reports. The registry also offered the ability to analyze factors that affect outcomes, such as smoking and severity of hearing loss. Discussion: The registry accrues prospective data on defined outcomes from multiple centers and allows for analysis of factors affecting outcomes. This registry does not have a control group, which is a limitation. Nevertheless, the registry provides a unique, comprehensive dataset on HBO2 outcomes from multiple centers internationally.
The effect of hyperbaric oxygen therapy on bladder symptoms of female patients with overactive bladder
Authors:   Department of Urology, Konya City Hospital Health Application and Research Centre, Health Sciences University, Konya, Turkey, Hamarat Mustafa B , Arslan Abdullah ,   Department of Underwater and Hyperbaric Medicine, Meram Medicine Faculty, Necmeddin Erbakan University, Konya, Turkey
Published: August 2022

Overactive bladder (OAB) is a disease with symptoms such as feelings of urgency, nocturia, and frequent urination which is usually accompanied by urinary incontinence. We aimed to assess the effect of hyperbaric oxygen (HBO2) therapy on the symptoms of female patients with overactive bladder (OAB). This study is a prospective observational cohort study. The patients were analyzed into two groups. The patients who received HBO2 therapy were in Group 1, and the patients who received mirabegron treatment were in Group 2. The symptom scores and quality of life scores of the patients before and after treatment were recorded and compared. Significant improvement in symptom scores were seen in both groups after treatment compared to baseline. The study included 31 patients in Group 1 and 44 patients in Group 2. The mean changes in the ICIQ-SF, OAB-V8, and IIQ-7 scores in the third month of treatment in Group 1 were 4.12 ± 3.51, −10.70 ± 6.92, and −4.51 ± 2.68, respectively. The corresponding mean score changes in Group 2 were −4.31 ± 3.16, −11.22 ± 5.93, and −3.68 ± 2.67, respectively. The mean changes in all three scores were not significantly different between Groups 1 and 2 (p = 0.81, 0.73, and 0.19, respectively). We observed that HBO2 treatment improved quality of life by reducing the symptom score in patients with OAB. Moreover, this effect continued in the third month after the treatment. Considering the efficacy and side effect profiles of the available treatments, HBO2 therapy may be a new treatment alternative in OAB.
Decompression sickness with incidental pulmonary cyst
Authors:   Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain, LDS Hospital, Salt Lake City, Utah, U.S., Norton Mariesa N , Weaver Lindell K ,   Division of Hyperbaric Medicine, Intermountain Medical Center, Murray, Utah and Intermountain, LDS Hospital, Salt Lake City, Utah, U.S.,   Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, U.S.
Published: August 2022

Decompression sickness (DCS) is a known complication of scuba diving. DCS occurs when bubbles are formed as pressure is reduced during and after ascent from a dive, following inert gas uptake during the dive. The bubbles cause inflammation and hypoxia. The definitive treatment for decompression sickness is hyperbaric oxygen therapy. We present a case of a healthy 16-year-old male who presented with decompression sickness and an incidental pulmonary cyst discovered by chest CT, likely congenital. The patient was successfully treated with U.S. Navy Treatment Table 6 (TT6) for his decompression sickness, but he continued to have chest pain, requiring hospitalization and consultation with pediatric pulmonology and cardiothoracic surgery from the cyst. Three years later he complained of chest pain with changes in altitude. Chest CT showed persistence of this cyst, and additional cysts. Case conference with pulmonologists and chest radiologist could not offer a definite etiology without lung biopsy, felt to not be indicated. We believe that the changes in pressure/volumes during the dives and TT6 exacerbated his pulmonary cyst.
Comparison of four low-level carbon monoxide alarms suitable for home use or when traveling
Authors:   Section of Hyperbaric Medicine, Virginia Mason Medical Center, Seattle, Washington U.S.., Hampson Neil B , Holm James R ,   Section of Hyperbaric Medicine, Virginia Mason Medical Center, Seattle, Washington U.S..
Published: August 2022

Introduction/Background: Interest in carbon monoxide (CO) alarms that are more sensitive than is required for standard residential CO alarms is growing, as reflected by increased marketing of “low-level” alarms capable of measuring CO levels as low as 10 PPM. At the same time, publicity surrounding CO poisoning events among travelers in lodging facilities has stimulated interest in travel CO alarms. We sought to evaluate four low-level alarms that could be used in the home and especially when traveling. Materials/Methods: Two each of four brands of low-level alarms (CO Experts, Forensics, Kidde, and Sensorcon) were acquired by retail purchase and tested. The eight alarms were simultaneously exposed in an environment with a slowly increasing level of CO from indoor burning of charcoal briquets. CO levels displayed on the alarms were recorded once per minute. Activation of preset alerts on the alarms were noted. Finally, alarms were compared for ease of use and features available. Results: All brands of alarms measured CO similarly over the range from 10-120 PPM. All alarms performed as claimed by their manufacturers, both regarding range of CO reported and preset alert activation. Each alerted at CO levels below that required by the Underwriters Laboratories 2034 Standard. Summary/Conclusions: Since all low-level CO alarms tested measured CO similarly, consumers seeking a low-level CO alarm for use while traveling should base their decision on features desired and price. There are definite differences between the alarms tested, in terms of features, expected durability, ease of operation and price. 10.22462/05.06.2022.4
Effects of hyperbaric oxygen therapy on exercise-induced muscle damage
Authors:   University at Buffalo, Department of Exercise and Nutrition Science, Center for Research and Education in Special Environments, Buffalo, New York U.S., Presti Nicole , Huang Enoch ,   Legacy Emanuel Hyperbaric Medicine , Portland, Oregon  U.S., Pryor J Luke ,   University at Buffalo, Department of Exercise and Nutrition Science, Center for Research and Education in Special Environments, Buffalo, New York U.S., Hostler David ,   University at Buffalo, Department of Exercise and Nutrition Science, Center for Research and Education in Special Environments, Buffalo, New York U.S.
Published: August 2022

Purpose: To perform a literature review on hyperbaric oxygen (HBO2) therapy as a treatment forexercise-induced muscle damage (EIMD). Methods: PubMed, Web of Science and Google Scholar were searched for articles related to HBO2 therapy as a treatment for exercise-induced muscle damage. Inclusion criteria included HBO2 therapy as the primary intervention to treat EIMD. Articles used in this review ranged from 1995-2021. Conclusion: Current literature on the effectiveness of HBO2 therapy to treat EIMD is mixed. Early and frequent treatments seem to be important factors when it comes to the success of HBO2 therapy. Additional research is needed to determine if HBO2 therapy has potential to treat more severe forms of EIMD and the role HBO2 therapy has on inflammation and satellite cell function after EIMD.
Comparison of Perioperative and Oncologic Outcome Between Old Versus Oldest Old After Radical Cystectomy for Bladder Cancer
Authors: Park Sang Soo , Lee Chung Un , Chung Jae Hoon , Song Wan , Kang Minyong , Sung Hyun Hwan , Jeon Hwang Gyun , Seo Seong Il , Jeon Sung Soo , Lee Hyun Moo , Jeong Byong Chang
Published: August 2022

Purpose: The purpose of study was to compare oncologic outcomes (recurrence-free survival [RFS], cancer-specific survival [CSS], and overall survival [OS]) and early complication (within 30 days) after radical cystectomy (RC) between old patients (70–79 aged) and oldest-old patients (above 80).Materials and Methods: This retrospective study reviewed total 340 patients with urothelial carcinoma of bladder who received RC between November 1996 and December 2018. The patients were divided into 2 groups by age, 307 patients aged 70–79 and 33 patients aged above 80. Baseline characteristics, perioperative outcomes and early complication were compared between the 2 groups. Kaplan–Meier (K-M) survival analysis was used to estimate RFS, CSS, OS, and multivariable Cox proportional hazard models were used to identify factors predicting RFS, CSS, OS.Results: The results of both groups did not statistically differ from each other in most clinicopathologic baseline characteristics and perioperative information. Both groups showed similar 30-day complication rates (59.3% vs. 60.3%, p=0.210). K-M showed 3-year survival rate, RFS was shorter in oldest-old group (41.4% vs. 56.7%) but not statistically different (p=0.063). Oldest-old group showed similar 3-year CSS (78.1% vs. 74.6%, p=0.779) but worse OS (51% vs. 58%, p=0.047) compared with the old group. Common factor affecting RFS, CSS, and OS were T stage and N stage (all p<0.05). Age is not factor affecting RFS, CSS, and OS.Conclusions: Oldest-old who received RC had similar perioperative, oncologic outcome and complication compared with the seventies. RC could be considered treatment option for selected oldest-old patients.
TINGKAT KEMAMPUAN BERBICARA PEMELAJAR BIPA (BAHASA INDONESIA PENUTUR ASING) TINGKAT PEMULA MENGGUNAKAN TES TEKS DESKRIPSI
Authors: Faiza Fikis Silmi , Irsyad Rosida Erowati
Published: August 2022

Dalam pengajaran BIPA, berbicara menjadi aspek keterampilan berbahasa yang fundamental. Komunikasi lisan atau kemampuan berbicara merupakan salah satu keterampilan bahasa yang penting. Hal ini menyangkut keluasan identifikasi persoalan berbicara. Kemampuan berbicara pemelajar BIPA tingkat pemula mencakup kemampuan dalam mendeskripsikan secara lisan, ketepatan kalimat, ketepatan pelafalan dan ketepatan kosakata. Penelitian ini bertujuan mengetahui tingkat kemampuan berbicara pemelajar BIPA tingkat pemula asal Belanda menggunakan tes teks deskripsi dengan menggunakan metode deskriptif kualitatif dengan menggunakan tes dan penilaian berdasarkan penilaian Common European Framework of Reference for Languages (CEFR) yang disesuaikan. Penelitian ini juga menggunakan transkripsi fonetik untuk mengetahui ketidaktepatan pelafalan pada beberapa artikulasi fonetik. Hasil penelitian ini menunjukkan bahwa pemelajar BIPA tingkat pemula menggunakan tes teks deskripsi memiliki kesulitan namun berada dalam kategori baik dalam penilaian.
An exact analytical solution to the non-stationary coagulation equation describing the endosomal network dynamics
Authors: Makoveeva Eugenya
Published: August 2022

Motivated by important applications in materials science and biology, we
consider a non-stationary coagulation equation with in-flux and out-flux
of particles (cargo). An exact analytical solution to this
integrodifferential equation is found in a parametric form. This
solution behaves as a decaying exponent with respect to the particle
volume (fluorescence intensity in the case of coagulation of endosomes).
We demonstrate that our exact solution substantially depends on
coagulation kernels (fusion and fission rates) as well as the in-flux
and out-flux processes of cargo.
Atrial arrhythmias with mediastinal lymphadenopathy presentation of Isolated atrial myocarditis.
Authors: KUMAR SHARATH , Yalagudri Sachin , Saggu Daljeet , Mansoor M. , K Vijaya Tourani , Narasimhan Calambur
Published: August 2022

Objectives: We present a case series of patients with granulomatous
myocarditis presenting as atrial arrhythmias accompanied by
lymphadenopathy. Background: Atrial myocarditis (AM) may be the cause of
atrial arrhythmias in patients without risk factors for atrial
fibrillation. (AF). Methods: Patients with atrial arrhythmias without
traditional risk factors for AF underwent 18F Fluorodeoxyglucose
positron emission tomography (18F FDG PET). We performed biopsy of
either the myocardium or draining lymph nodes in patients with atrial
uptake of 18F FDG PET. We found evidence of AM in 15 patients. Results:
The mean age of the patients was 43.33±12.59 years with a male
predominance (73.3%). The left ventricular ejection fraction (LVEF) at
presentation was 48.07±12.29% and the left atrial volume was 37.6±10.64
ml. All patients had AF at presentation, atrial flutter was noted in 4
patients (26.7%) and 2 patients (13.3%) had atrioventricular nodal
reentrant tachycardia (AVNRT). F FDG PET uptake was
noted in the atria in all patients and in the ventricles in 3 patients
(20%). Cardiac sarcoidosis was the diagnosis in 12 patients (80%)
while 3 patients (20%) had evidence of tuberculosis. The mean CHA2DS2
Vasc score of the patients was 1.06±0.93. Four patients (26.7%)
presented with ischemic stroke. All patients were treated with disease
specific therapy (immunosuppression or anti-tuberculosis therapy) in
addition to standard anti-arrhythmic medications. Over a mean follow up
of 30.53± 13 months we observed a significant improvement in clinical
status commensurate with a decline in atrial uptake. There was a
non-significant improvement in LVEF to 56±12.07% with disease specific
therapy. (p=0.0853) Conclusions: Atrial arrhythmias with granulomatous
lymphadenopathy may be a presenting feature of Atrial myocarditis. The
risk of stroke seems to be high in these individuals. This syndrome
should be suspected in young individuals presenting with atrial
arrhythmias and stroke without conventional risk factors.
Insight into the green path to dimethyl succinate by direct esterification of sodium succinate using CO2 and CH3OH
Authors: Wang Yugao , Han Xiao-chen , Gu Bao , Wu Hua-shuai , Shen Jun , Wei Xian-Yong
Published: August 2022

The fermentation for the production of succinic acid (SA) outperforms
other methods by low energy consumption and environmental benignity,
with the resulted products mainly as disodium succinate (DSA). By the
direct esterification of DSA using CO2 and CH3OH, it is expected to
avoid the use of inorganic acids in downstream industrial esterification
of bio-based DSA. By high-resolution mass spectrometry analysis and
theoretical calculation,this study establishes that the direct
esterification of DSA consists of three steps by first forming
3-carboxypropanoate,then monomethyl succinate (MMS),and finally DMS. The
reaction kinetics of DSA direct esterification is also investigated by
experiment and simulation with MATLAB, and the reaction kinetics
equation along with reaction rate constant are obtained. The activation
energy for the generation of MMS from DSA is 37.15 kJ/mol,and the one
for the generation of DMS from MMS is 85.80 kJ/mol,indicating the latter
one is the rate-determining step for the direct esterification of DSA.
High HbA1c levels are associated with development of trigger finger in type 1 and type 2 diabetes – an observational register-based study from Sweden
Authors: Rydberg Mattias , Zimmerman Malin , Gottsäter Anders , Eeg-Olofsson Katarina , Dahlin Lars B.
Published: August 2022

  

Objective

Trigger finger (TF) is a hand disorder causing the fingers to painfully lock in flexion. Diabetes Mellitus (DM) is a known risk factor, however, whether strict glycemic control effectively lowers the risk of TF is unknown. Our aim was to examine if a high HbA1c was associated with increased risk of TF among individuals with DM.

 Research Design and Methods

The Swedish National Diabetes Register (NDR) was crosslinked with the healthcare register of the Region of Skåne in southern Sweden. In total, 9,682 individuals with type 1 diabetes (T1D) and 85,755 individuals with type 2 diabetes (T2D) aged ≥ 18 years were included from 2004 to 2019. Associations between HbA1c and TF were calculated using sex-stratified, multivariate logistic regression models with 95% confidence intervals (CI), adjusted for age, duration of DM, body mass index, and systolic blood pressure.

Results

In total, 486 women and 271 men with T1D and 1,143 women and 1,009 men with T2D were diagnosed with TF. Increased levels of HbA1c were associated with TF among individuals with T1D (women OR 1.26; 95% CI: 1.1 – 1.4, p = 0.001, men OR 1.4; 95% CI: 1.2 – 1.7 p < 0.001) and T2D (women OR 1.14; 95% CI: 1.2 – 1.2, p < 0.001, men OR 1.12; 95% CI: 1.0 – 1.2, p = 0.003).

Conclusions

Hyperglycemia increases the risk of developing trigger finger among individuals with T1D and T2D. Optimal treatment of DM seems to be of importance in order to prevent diabetic hand complications such as TF. 