bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in Women’s Menstruation Patterns Following COVID-19 Infection
Authors: Nisman Wenny Artanty , Imam Rahmawati Natasya Putri , Ramadhani Hanin , Mardliyah Ainun Saidatul , Kusumawati Happy Indah , Wibawa Shinta Restu , Hapsari Elsi Dwi , Retno Hersinta
Published: December 2024

The Coronavirus Disease 2019 (COVID-19) has been demonstrated to disrupt the body's immune response, adversely affecting the reproductive system. Consequently, this study has focused on the changes in the menstruation patterns of survivors of the disease in women of reproductive age with asymptomatic, mild, and severe cases. This study employed an observational cross-sectional approach. The sample comprised 207 women who had recovered from COVID-19 within the past six months and met the inclusion and exclusion criteria. The sampling technique utilized consecutive sampling, and menstrual characteristics were assessed using a questionnaire. Several respondents in the severe group experienced changes in their menstrual patterns. Their duration of menstruation was shortened by 11.11%, and 13.58% had a more extended menstrual period. Some respondents’ cycles were elongated by 20.98%, some decreased their initial menstrual volume by 32.09%, and some increased by 27.16%. Meanwhile, their menstrual volume decreased by 17.28% at the end of menstruation, and their duration lengthened by 24.69%. 12.1% of respondents also reported changes in menstrual regularity. Additionally, 19.75% of respondents stated that their menstrual pain decreased, and 13.58% had increased menstrual pain.  The multivariate analysis revealed that the severity of the COVID-19 infection was the primary factor influencing menstrual patterns.
Utilization of Used Cooking Oil from Street Vendor: Recycle and Anti-Oxidant Enrichment with Moringa oleifera leaves
Authors: Ismet Rhahmasari , Sianipar Rut Novalia Rahmawati , Adelia Nesha , Filaila Euis , Jovianto Andrian , Firdaus Ridwan , Hanifah Hanifah , Dwiastuti Rahma , Aninda Yunita , Alfiona Della , Akmalina Rifkah , Iswantini Dyah , Prasetyo Joni
Published: December 2024

Used cooking oil (UCO) is abundant in Indonesia because of lifestyle of people. Especially UCO from street vendors had very low quality based on its Free Fatty Acid (FFA) content that reached 5.074%. When UCO was deposed into drainage, it would pollute the environment. Low grade UCO from street vendors contained Unsaturated-Fatty-Acid, Saturated-Fatty-Acid, and other hydrocarbons. Recycling UCO to replace edible oil considered more desirable rather than biodiesel since higher added value. FFA was the most undesired compound affecting cooking oil quality. FFA reducing with diluted 0.1 M NaOH 10% v/v could reduce FFA from 5.07% to 0.53%. Bleaching earth (BE) content mostly Si, Nb, Al, Ca and Na was safe to treat UCO for edible cooking oil. BE played cleaning UCO but absorbed the oil 17%. ANOVA analysis for BE and Moringa oleifera leaves (MOL) treatment fits with Reduced Quadratic model. Based on the ANOVA, the model showed that the decrease of FFA was determined significantly by BE amount and temperature with P-values less than 0.05. Optimization for BE treatment was done using Response Surface Method to find out the lowest FFA. And based on the simulation, it was obtained 0.2854% while the experimental results showed 0.2908%. Furthermore, BE combined with Moringa oleifera leaves (MOL) that known anti-oxidant source was used to treat UCO. UCO originally content stronger anti-oxidant activity rather fresh palm oil with IC50 62.12 and 83.03 mg/kg, respectively. Stronger anti-oxidant in UCO allegedly derived from fried foods. Treatment 10% BE and 5% MOL considered optimal for good appearance edible oil, little yellow greenish. Moreover, GC/MS analysis showed improvement active compounds in treated UCO with 5, 7.5 and 10 g MOL in 150 ml UCO with 24.36%, 30.32% and 37.76% active compounds, respectively. Moreover, anti-oxidant measured with IC50 the treated UCO were 43.18, 42.33 and 41.78 mg/kg, respectively. Increasing the number of MOL did not significantly increase the anti-oxidant activity. Anti-oxidant detected in treated UCO identified such as ethyl acridine, indolizine derivatives, cyclotrisiloxane-hexamethyl, benzimidazoles, and Fumaric acid. Based on the results, UCO recycling is applicable for a community, save expenses and strengthen food security and food sovereign. Further thought for its implementation is to design an integrated system from collecting UCO in a reservoir tank equipped with filter, recycling process and finally product tank at mini plant scale.
Keywords: Anti-oxidant enrichment, bleaching earth, edible treated UCO, Moringa oleifera leaves (MOL) , UCO recycle
Preliminary Studi of Dye-Sensitized Solar Cell Photoelectrochemical for CO2 Conversion to Methanol Using CuO-modified Dark TiO2 Nanotubes Array as Cathode
Authors: Arda Hany Dwi , Syauqi Muhammad Iqbal , Gunlazuardi Jarnuzi
Published: December 2024

The increased atmospheric carbon dioxide (CO2) levels can lead to climate change and adversely affect human health. Therefore, it is necessary to develop a method to capture CO2 and convert it into a more valuable substance, such as methanol. In this study, we established a tandem system involving dye-sensitized solar cells and photoelectrochemical (DSSC-PEC), which included the PEC zone using CuO/dark TiO2 nanotube array (CuO/dTNA) as the dark cathode where CO2 reduction takes place, and Co-Pi/blue TiO2 nanotube array (Co-Pi/bTNA) as the counter photoanode. For the DSSC zone, N719/TNA was used as the photoanode, I-/I3- electrolyte, and Pt/FTO as the cathode. The tandem system was constructed by connecting the PEC cathode to the DSSC photoanode and the PEC photoanode to the DSSC cathode using silver wire. Under solely visible light induction and water containing sodium bicarbonate electrolyte saturated with CO2, the proposed devise produced methanol at 1.292 μmol/hour.
Keyword: Carbon dioxide, copper oxide, dark TiO2 nanotube, DSSC-PEC
Antioxidant and Anti-inflammatory Activities of Diarylheptanoid from Etlingera calophrys Fruit
Authors: Karmilah Karmilah , Yodha Agung Wibawa Mahatva , Hamsidi Rini , Daud Nur Saadah , Malaka Muhammad Hajrul , Musdalipah Musdalipah , Sahidin Sahidin
Published: December 2024

Diarylheptanoids compounds from the genus Etlingera have attracted widespread attention due to their various structural diversity and potential pharmacological effects. This is certainly an important part to continue to study, especially from Sulawesi endemic species, one of which is Etlingera calophrys. The fruit of E. calophrys is widely utilized in the Sulawesi community. The lack of information on the content of chemical compounds and their pharmacological activities, so the study is very important. Diarylheptanoid compounds were obtained by chromatography technique, molecular structure interpretation by spectroscopy technique while pharmacological activity was tested against radical scavenging as antioxidant and inhibition of protein denaturation as anti-inflammatory. Two diarylheptanoid compounds were successfully isolated from E. calophrys fruit namely 1-(3'-methoxy-4'- hydroxyphenyl)-7-phenyl- 3-heptanone and 1-(3'-methoxy-4'- hydroxyphenyl)-7-(4"-hydroxyphenyl)- 3-heptanone. Antioxidant properties showed very strong ability with IC50 values of 32.21 ± 0.42 and 21.64 ± 0.63 µg/mL, respectively, while anti-inflammatory properties were strongly shown by the compound with IC50 values of 25.71 ± 0.54 and 15.28 ± 0.66 µg/mL, respectively. The presence of diarylheptanoid content that has good pharmacological activity can support the used of E. calophrys as a nutraceutical source.
Keywords: Anti-inflammatory, antioxidant, diarylheptanoid, Etlingera calophrys, fruit
Investigation into the Phytochemical Profiles, Antibacterial and Antioxidant Potentials of Toona sinensis Stem Bark Part
Authors: Santoni Adlis , Efdi Mai , Salim Emil
Published: December 2024

Toona sinensis has been used as a traditional medicine to treat diarrhea, dysentery, and fever. In the present study, the stem bark extracts of T. sinensis were investigated to determine the antibacterial activity, total phenolic content, 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, and chemical constituent using gradual extraction by maceration method with hexane, ethyl acetate, and methanol respectively. In vitro, antibacterial activity was evaluated against Staphylococcus aureus and Escherichia coli by agar well diffusion method. The hexane fraction was more sensitive to S. aureus and the ethyl acetate and methanol fractions were more sensitive to E. coli. The methanol extract showed the highest total phenolic content and antioxidant activity. Phytochemically, Toona sinensis stem bark extract contained phenolic, flavonoid, steroid, triterpenoid, and coumarin. Investigation of ethyl acetate extract produced 5,7,3',4'-tetrahydroxyflavan-3-ol (catechin).
Keywords: Antibacterial, antioxidant, catechin, Toona sinensis, total phenolic content
Antioxidant Release Profile from Chitosan/ĸ-Carrageenan-based Polyelectrolyte Complex Films as Active Packaging: A Preliminary Study
Authors: Rahmasari Khusna Santika , Ishartono Bayu
Published: December 2024

Significant efforts are necessary to prevent the spoilage of fatty acid-rich foods as a result of lipid oxidation. Active packaging is a technology that employs packaging films containing antioxidants to increase the stability of perishable foods susceptible to oxidation. This preliminary study aimed to incorporate tannic acid (TA) into a chitosan/κ-carrageenan (Chit/κ-Car)-based polyelectrolyte complex (PEC) films and evaluate their antioxidant release profile. The composition of Chit/κ-Car, glycerol (gly), and TA in PEC films were also investigated in this preliminary study as factors influencing the mechanical properties of films and the antioxidant release profile. The prepared PEC films were identified by an FTIR spectrometer and examined through a mechanical property test. The DPPH method was used to assess the antioxidant property of the Chit/κ-Car-based PEC films. The infrared spectra revealed that PEC films were formed through the interaction between ꟷNH3+ of Chit and ꟷOSO3ꟷ of κ-Car. Increasing the κ-Car and TA compositions in the PEC films increased the tensile strength (TS) and water absorption capacity (WAC), but decreased the elongation (E). The release profile of TA from PEC films followed the Korsmeyer-Peppas model through the Fickian diffusion mechanism with n < 0.5. The antioxidant activity test of PEC films using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method revealed high antioxidant activity with radical scavenging activity (RSA) values up to 95.04%. As a result, the Chit/κ-Car-based PEC films have the potential to be developed as active packaging.
Keywords: Active packaging, antioxidant, Chit/κ-Car-based PEC films, release profile, TA
Authors: RAHMAWATI YULIA , Hartono Hartono , Abdullatif Farzand
Published: December 2024

Ketersediaan energi listrik memiliki peran penting bagi rumah tangga dan industri. Transformator distribusi merupakan komponen vital dalam energi listrik yang memiliki peran penting dalam pendistribusian energi listrik ke konsumen. Gangguan pada transformator seperti overload dan overheat dapat terjadi dan menurunkan kinerja sistem distribusi listrik. Oleh karena itu, penting untuk melakukan monitoring transformator. Penelitian ini bertujuan untuk merancang dan membuat sistem monitoring transformator berbasis Internet of Things (IoT) menggunakan aplikasi Blynk. Hasil penelitian menunjukkan bahwa sistem monitoring berhasil dibuat dan berfungsi dengan baik dalam memantau suhu, arus, dan tegangan transformator dengan akurasi tinggi, yaitu 99,44% untuk suhu, 98,35% untuk arus, dan 98,09% untuk tegangan. Hasil monitoring transformator dapat diakses secara real-time melalui aplikasi Blynk. Selain itu, sistem otomatisasi bekerja sesuai harapan dengan mematikan beban secara otomatis dan mengirimkan notifikasi ke smartphone pengguna saat suhu mencapai nilai set point yang ditentukan, yaitu >50°C.
Perendaman Ekstrak Daun Sirih Terhadap Nilai Kelulushidupan dan Profil Darah Ikan Nila (Oreochromis niloticus)
Authors: Bintang Yustika Eka Fauziah
Published: December 2024

The use of betel leaf extract as a natural medicinal ingredient. Treatment can be done using the soaking method. The aim of this research is to determine the effect of immersion in betel leaf extract on the survival and blood profile of tilapia fish. This research used an experimental method with 4 treatments (control, 400 ppm, 600 ppm, 800 ppm). The research parameters are the survival and blood profile of tilapia which includes hemoglobin, hematocrit, blood glucose, leukocyte differentiation and water quality. After maintenance for 5 days, the research results showed that the survival rate of tilapia fish ranged from 40-80%. Blood profile values include hemoglobin, hematocrit and blood glucose values respectively in the range of 7-8.1 g/dL, 20.85 - 23.85% and 47 - 104.5 mg/dL. The percentage values of leukocyte differentiation which include monocyte, lymphocyte and polymorphonuclear values are 16.5 – 23.5%, 54 – 61.4% and 18- 23.5%, respectively. The temperature in the maintenance pond is 26-27oC, pH is 6-8 and Dissolved Oxygen (DO) is 3.4-3.9. The water quality of the tilapia rearing pond is still within the normal range.
Distribusi Kalsium (Ca) Pada Daerah Aliran Sungai Serayu
Authors: Fikriyya Nabela , Putri Desta Fatma , Jatmoko Bambang Eko , Firdaus Abdul Malik
Published: December 2024

Serayu River Watershed is one of the watersheds in Central Java that covers several districts including Wonosobo, Banjarnegara, Purbalingga, Banyumas, and Cilacap. The condition of the Serayu River Watershed at this time has experienced damage and environmental pollution which has resulted in a decrease in the quality of Serayu River Water. Calcium is one of the minerals present in water and sediment. Calcium content is influenced by reactions involving carbon dioxide gas either due to respiration of plants or aquatic animals. The presence of domestic wastewater is an external element that can affect high calcium concentrations in waters. The purpose of this study was to determine the distribution of Calcium (Ca) in the Serayu River Watershed. Sampling was conducted in November 2023 located in the Serayu Watershed Area. Sampling was carried out at 15 points of the Serayu River Watershed. The method used is titrimetric analysis. The analysis results obtained are the highest Calcium (Ca) value found in Menyawak River at 52.40 mg/L. The calcium distribution map shows a red interpolation color. The lowest Calcium (Ca) value is found in the Kalisapi River at 19.20 mg/L. The calcium distribution map shows a yellow interpolation color.
Aspek Reproduksi Ikan Nila (Oreochromis niloticus Linnaeus, 1758) di Waduk Panglima Besar Soedirman, Kabupaten Banjarnegara, Jawa Tengah
Authors: Mulyaningsih Andina , Putri Adinda Kurnia , Sulistyo Isdy , Nasyrah Adiara Firdhita Alam
Published: December 2024

Ikan nila (Oreochromis niloticus, Linnaeus 1758 Linnaeus, 1758) merupakan jenis ikan yang banyak ditemukan di Waduk P.B. Soedirman. Tujuan dari penelitian ini untuk menganalisis aspek reproduksi ikan nila meliputi rasio kelamin, tingkat kematangan gonad, indeks gonadosomatik, fekunditas, dan diameter telur. Penelitian ini dilakukan pada bulan Agustus dan September 2023. Sampel ikan nila yang diperoleh selama penelitian berjumlah 70 ekor ikan nila, yang terdiri dari 32 ekor ikan jantan dan 38 ekor ikan betina. Rasio kelamin ikan nila jantan dan betina menunjukkan berada pada kondisi seimbang. Tingkat kematangan gonad jantan didominasi oleh TKG I sedangkan betina oleh TKG I dan II. Nilai IGS secara menunjukkan bahwa ikan nila betina memiliki nilai IGS lebih tinggi dibandingkan jantan. Fekunditas ikan nila selama penelitian memiliki kisaran 175-1382 butir telur dan dapat dikategorikan sebagai partial spawner.
Pendampingan Branding, Packaging, dan Digital Marketing Tingkatkan Penjualan Madu Kelulut Desa Tuwung
Authors: Yuliana Yuliana , Agnestisia Retno , Saputra Rizki Rachmad , Pasaribu Marvin Horale
Published: December 2024

Tuwung Village, located in the Kahayan Tengah District, Pulang Pisau Regency, Central Kalimantan, has significant potential in managing social forestry land to support food security. The local community, organized in the Social Forestry Business Group (KUPS), has successfully cultivated 120 hives of stingless bees (Trigona sp.), with monthly production capacity of up to 350 mL per hive. Although honey production is abundant, its sales remain very limited due to a marketing strategy that relies solely on word-of-mouth promotion. Therefore, this community service activity was introduced to provide guidance to KUPS Madu Kelulut on branding, product packaging, and digital marketing. With an attractive brand, high-quality packaging, and the right marketing strategy, it is hoped that the stingless bee honey business can become more competitive in a market already saturated with similar products. This community service program involved several stages, including preparation, implementation, and evaluation. The activity was carried out on July 9, 2024, with 40 participants. The evaluation results indicated an 81.25% increase in participants' understanding of branding, product packaging, and digital marketing. Furthermore, the participants successfully created the brand "Madu Kelulut Nyai Hapu," with an appealing packaging design and effective promotional content shared through social media and e-commerce platforms.
Upravljanje vremenom i odnosi moći
Authors: Benčić Kužnar Andrijana
Published: December 2024

Sociologija vremena je u posljednjih dvadesetak godina prošla značajan razvojni put, odnosno tek se nedavno razvila u utemeljenu granu koja i dalje razvija svoj distinktivni sociološki vokabular. Dosadašnja istraživanja unutar sociologije vremena bavila su se uglavnom odnosom vremena i tehnologije, globalizacije, kapitalizma i digitalizacije. S druge strane, unutar te posebne sociologije teorijski i empirijski sve do danas izostaje razrada vremena u kontekstu politike, odnosno u kontekstu odnosa moći i društveno-političkih promjena. U ovom se radu, kao doprinos daljnjim istraživanjima i razmatranjima socioloških odnosa vremena i politike, analiziraju tri studije slučaja: uvođenje francuskog revolucionarnog kalendara u Francuskoj Republici 1793. godine, uvođenje sovjetskog revolucionarnog kalendara u Sovjetskom Savezu 1929. godine i prelazak na ljetno računanje vremena u Libanonu 2023. godine. Zaključak je rada da daljnja istraživanja temporalnih komponenti političkih procesa mogu doprinijeti obogaćivanju sociologije vremena, kao i formiranju posebne grane – političke sociologije vremena.
ANALISIS PENYELESAIAN UTANG PIUTANG PADA LAYANAN FINTECH LENDING MELALUI KEPAILITAN & PKPU
Authors: Faqi Ahmad Fachri , Jamila Fadilla
Published: December 2024

Debt settlement in Fintech Lending services has been regulated under POJK 10/2022. In addition to dispute resolution through the district court or alternative dispute resolution, there are Bankruptcy and PKPU mechanisms to resolve debt issues in Fintech Lending services.. This research analyzes the settlement of debts in Fintech Lending services through Bankruptcy and Suspension of Debt Payment or PKPU institutions as a fairer, faster, and more effective alternative. The research method used is normative legal research using secondary data such as laws and regulations and related legal literature. Data collection techniques are carried out through documentation studies or literature studies. The results showed that debt settlement in Fintech Lending services can be done through Bankruptcy and PKPU, because the debt is included in the scope of Law 37/2004. However, there are obstacles in the application of debt collection principles in Law 37/2004, such as the requirement of advocates and the number of creditors that make it difficult for individual debtors. In addition, Law 37/2004 has not fully protected individual debtors because debt relief still requires creditor approval.
Health in the system of teachers’ values: health-saving behavior and lifestyle
Authors: Azarov T. A. , Mikerova M. S. , Sokolov N. A.
Published: December 2024

Introduction. The eﬀectiveness of the educational process depends not only on the professional competence of the teacher, but also on the physical and mental state of his health. With the best outcome, the above means that they follow a proper lifestyle (sports, balanced nutrition, sleep, disease prevention, etc.), take care of their own body, as well as the formation of health-saving behavior among students by demonstrating a personal example and spreading knowledge within the framework of this direction.

The purpose of the study is to determine the place of health in the value system of teachers.

Materials and methods. The place of the study was general education schools in Moscow and the Moscow region. The following research methods were used: analytical, sociological, statistical. The survey was conducted using a questionnaire developed by the authors; the questionnaire included 69 questions. The survey of teachers was conducted online via the resource https://docs. google.com/ from February to May 2024. 233 teachers took part in the survey.

Results. A signiﬁcant part of teachers (45.1%) consider their own lifestyle healthy, however, 40.3% of respondents rarely engage in physical activity, the duration of night sleep for half of the respondents is 5–6 hours, 57.9% are unable to maintain time intervals for eating, a signiﬁcant part of teachers are stressed due to work most of the time. 41.2% of respondents assess their current state of health as good; 36.5% of respondents indicated the presence of chronic diseases diagnosed by a doctor. The majority of respondents note the high importance of personal health for themselves – 39.5% of respondents consider health to be very important, and 52.8% – simply important. The majority of teachers (98.3%) believe that they are personally responsible for their health. Half of the teachers surveyed indicated that the school is responsible for shaping the lifestyle of children; 90.6% of respondents believe that there is a need to discuss issues of health and a healthy lifestyle at school.

Conclusion. The results of the study indicate a positive assessment of the state of their own health by school teachers and demonstrate its importance for this category of citizens. However, not all of the respondents lead a healthy lifestyle. To strengthen the health of teachers, a set of measures is needed aimed at reducing stress levels, promoting a healthy lifestyle and supporting school staﬀ in seeking medical help.
Changes in the quality of the accessible environment when providing palliative care in 2021–2023
Authors: Buzin V. N. , Buzina T. S.
Published: December 2024

Introduction. Improving palliative care requires a comprehensive assessment of the quality of its provision from the point of view of patients and their immediate environment, including an assessment of the accessible environment for people with disabilities. The Russian Federation is one of the few countries where this task is set and solved at the state level.

The purpose of the study: to analyze the dynamics of the subjective assessment of the state of the accessible environment in medical organizations providing palliative care for the period 2021–2013.

Materials and methods. The material for the analysis was the results of a sociological survey of palliative care users over 18 years of age; relatives and legal representatives of adult (over 18 years old) patients in need of primary care; relatives and legal representatives of children (under 18 years of age) in need of primary health care, conducted in 2021–2023 using personal interviews at the place of residence. The following methods were used: descriptive statistics and the sociological survey method.

Results. In 2023, compared to 2021, the study showed a signiﬁcant increase in the proportion of respondents among recipients of palliative care over 18 years of age who noted subjective satisfaction with the equipment of medical organizations to receive people with disabilities. In the group of relatives of palliative care recipients over 18 years of age, compared to 2021, there is also a signiﬁcant increase in the share of respondents noting subjective satisfaction with the equipment of medical organizations for receiving persons with disabilities from 82% in 2021 to 95% in 2023. This suggests that the accessible environment for persons with disabilities in medical institutions is being improved within the framework of ongoing state and regional programs. A survey of parents of children requiring palliative care also shows a steady increase in satisfaction with the accessible environment in medical institutions over the same period from 85% to 90%. A small proportion of respondents (5–10% of all respondents) indicated some shortcomings in medical organizations, mainly related to the lack of handrails, a suﬃcient number of wheelchairs and accompanying personnel, and the lack of information stands in Braille).

Conclusion. A survey of people in need of palliative care and their relatives and legal representatives showed that in general the situation with the modernization of medical organizations in terms of creating an accessible environment for patients with disabilities is steadily improving. The vast majority of respondents say that they are completely satisﬁed with the state of the accessible environment of medical organizations providing palliative care.
Features of reproductive installations of modern youth
Authors: Vorontsova A. V. , Koval M. V. , Rosyuk E. A.
Published: December 2024

Introduction. Negative natural growth and aging of the population are urgent problems in the Russian Federation. The birth of children is closely related to marriage and the formation of a family, the existence of which on average lasts no more than 5 years for every third married couple according to domestic statistics. The institution of marriage in the Russian Federation is currently undergoing a crisis: a signiﬁcant number of early divorces, the massive spread of oﬃcially unregistered cohabitation, voluntary refusal to have children.

The purpose of the study: to study the features of reproductive attitudes and family values in modern Russian society on the example of students of the Ural State Medical University (UGMU).

Materials and methods. A one-stage descriptive study was conducted on the basis of the Department of Obstetrics and Gynecology of UGMU in February-March 2023. The assessment of students’ reproductive attitudes was found out by anonymous questionnaire using Google-forms. In total, 111 students of the 4th-5th year of USMU took part in the study. Microsoft Excel package was used for data analysis (USA, 2016). When scoring a certain parameter, the average value and the standard deviation were indicated.

Results. Young people aged 21–22 study at the 4th-5th courses of UGMU, mostly out of wedlock – 86.5%. 4.5% already have children, including 3 or more. 16.2% do not live a sexual life at all, the rest – in 55.9% of cases use a condom as a contraceptive. In the future, 89.9% of respondents plan to enter into an oﬃcial marriage under the age of 30, the male partner should be slightly older. The majority of the study participants – 62.5% – would like to have two children. In general, the younger generation has a positive attitude to the issue of adoption, ART methods.

Conclusion. The preservation of reproductive function with subsequent implementation is one of the most important life tasks for the younger generation.
Evaluation of awareness levels among population of Zabaikalsky krai for planning prophylactic measures to control HIV-infection and viral hepatitis spread (pilot study)
Authors: Taenkova I. O. , Trotsenko O. E. , Balakhontseva L. A. , Bazykina E. A. , Loginova N. Yu. , Korobkov A. V. , Belan E. A.
Published: December 2024

Introduction. Currently, much attention is being paid to studying the level of knowledge of the country's population and improving health literacy in relation to HIV infection and parenteral viral hepatitis. With insuﬃcient awareness of society about various aspects of social infectious diseases, morbidity increases, stigmatization of people living with HIV worsens, mortality increases and a tense situation in society is created.

The purpose of the study: to evaluate levels of awareness among population of the Zabailalsky krai of the Far Eastern Federal district in order to plan priority direction of HIV-infection an viral hepatitis preventive measures.

Materials and methods. To implement the goals and objectives of the research an analysis of population awareness levels about the issues of HIV and viral hepatitis was conducted after outreach event was performed. The questionnaire included 12 questions with a number of answers from 3 to 7 aimed at revealing awareness concerning the issues of HIV-infection and viral hepatitis. A total number of 312 people were examined. The research included sociological (questionnaire), statistical and comparative analysis.

Results. Results of the pilot study revealed a satisfactory level of population awareness on main questions concerning risks of obtaining infection and preventive measures against the diseases. However, answers on some of the questions indicated a need of additional attention during development/adjusting and implementation of diﬀerent preventive measures and educational programs. Youth mean age of whom equaled 15.6 years exhibited sympathetic behavior towards HIV-infected persons more frequently compared to adult population. Not quite satisfactory levels of awareness concerning ability of HIV-infected people to create family and have children was detected among adult population (mean age – 49.0 years). Some of surveyed people expressed a will to be tested for HIV. A total number of 90.5% of examined youth wanted to be tested but no one had a chance to do it because no one oﬀered it.

Conclusion. Taking in to account the obtained data for further development and implementation of prevention programs it is necessary to pay more attention to protection measures against HIV and hepatitis, emphasize attention on legal aspects of HIV and viral hepatitis issue as well as a necessity of regular testing to control HIV-status. Prevention work should include game-based learning to develop refusal skills to avoid risky behavior by playing out typical situations. It is necessary to continue the study and expand the number of respondents from diﬀerent key groups and conduct a comparative analysis of awareness levels before and after the outreach events in order to evaluate their eﬃciency.
Nutrition peculiarities and level of awareness in the issues of rational nutrition of the working population of the Sverdlovsk region
Authors: Semenova L. V. , Mironova E. N. , Zhuravleva P. V.
Published: December 2024

Introduction. The peculiarities of the culture of food consumption and the level of awareness in matters of nutrition of the working population of the Sverdlovsk region have been analyzed, the trends contributing to the formation of irrational nutrition have been noted, and recommendations for preventive work have been formulated.

The purpose of the study: to identify the peculiarities of food consumption culture and to determine the level of awareness of nutrition among the working population of the Sverdlovsk region.

Materials and methods. A quantitative method was used – an online survey using Computer Assisted WEB Interviewing (CAWI) technology with 2,500 respondents. Quota sampling by gender and age of respondents, with the deﬁnition of the territory of residence was calculated.

Results. The number of meals inappropriate to the recommendations, predominance of carbohydrate component in breakfasts and low representation of vegetables and fruits at any meal were revealed. The tendency to prepare food at home remains. A high level of awareness of working residents of the Sverdlovsk region on issues of rational nutrition was revealed – 73%, with a low level of awareness of the impact of dietary intake on the risk of chronic non-infectious diseases – 48%.

Conclusion. It is recommended to disseminate information on the relationship between nutrition and the risk of occurrence and development of chronic non-communicable diseases. Emphasis is placed on the importance of reading information on food labels to identify “hidden” sugar and salt. At the same time, the importance of informing about the norms of consumption of fruits and vegetables, ﬁsh, salt and sugar, as well as about the beneﬁts of following the recommended dietary regimen was emphasized. The authors note the need for a deeper analysis of the reasons for the discrepancy between the criteria “know” and “apply” in the issues of rational nutrition among the working population of the Sverdlovsk region.
Optical coherence tomography guided additional noevas bioresorbable vascular scaffold in the treatment of iatrogenic coronary artery dissection: A case report
Authors: Zhou Dengshuang , Huang Bobin , Chen Jue , You Qiong , Mo Hailiang , Wu Zijun , Lin Yubiao , Chen Lujun , Fan Junyu , Deng Wenyu , Wu Keng
Published: December 2024

Background: Iatrogenic coronary artery dissection is a potential complication during percutaneous coronary bioresorbable vascular scaffolds placement. We report that significant dissection occurred during post-expansion of the left rotatory branch bioresorbable vascular scaffolds to attach it to the wall. Additional resorbable stents successfully covered the dissection without blood flow restriction.
Casereport: The patient was a 49-year-old male with strong coronary implantable concept and was diagnosed with stable angina pectoris and type 2 diabetes. Coronary angiography showed serious lesions in three vessels. After a Noevas stent was inserted in the proximal segment of the anterior descending branch, secondary dissection occurred in the distal segment of the stent during Optical coherence tomography（OCT） examination when Noevas stent was inserted in the proximal segment of the circumflex branch. A third BVS was inserted to cover the dissection and OCT reexamination showed good adherence. After 6 months of coronary angiography, OCT examination showed no deterioration of the circumflex branch dissection, and the proximal intimal hyperplasia in the proximal BVS was 95%. Scoring balloon and drug balloon dilatation were successfully performed, and right coronary artery dilatation with drug coated balloon was performed. The patient had no symptoms of chest pain after 2 years of follow-up.
Conclusion: Additional bioresorbable vascular scaffold coverage of coronary D-type dissection with the help of imaging tools may be a practical strategy when patients have a strong desire for coronary metal-less implantation. Furthermore, imaging review is recommended especially for diabetics.
Effects of the Oral Health Promotion Program on oral health and oral microbiota in elderly diabetic patients: A quasi-experimental study
Authors: Liu Fan , Song Siping , Huang Shuqi , He Jing , Ye Xin , Hu Liwei , Zeng Xin , Deng Sicheng , Hu Xiuying
Published: December 2024

Background
Diabetes, which is highly prevalent, has become a major contributor to the burden of health care costs worldwide. Recent unequivocal evidence has revealed a bidirectional link between oral health and diabetes. In this study, the effects of the Oral Health Promotion Program (OHPP) on oral hygiene, oral health-related quality of life and glycated haemoglobin (HbA1c) levels were examined. At the same time, microbial changes in the saliva microbiota community were also investigated.
Methods
A quasi-experiment was conducted in regionally representative communities to assess participants’ oral health and oral microbiota. The participants in the intervention group (n = 26) received OHPP during the program, when those in the control group (n = 26) received routine oral care. Clinical parameters were recorded at two different time points: before the study (T0), and 3 months after intervention onset (T1). Oral health was measured via the oral health impact profile (OHIP-14) questionnaire, dental plaque index, HbA1c and mastery of oral health knowledge, and sequencing of the 16S rRNA gene from saliva samples was used to analyze the oral microbiota.
Results
The average age of the final sample was 71.77 years (SD = 6.06), 53.8% (28/52) of whom were male. A reduction in the plaque index and improvements in oral health-related quality of life and mastery of oral health knowledge were observed in the intervention group, and the richness and diversity of the microbiota increased. The relative abundance of Streptococcus decreased significantly in both groups. There was no statistically significant difference in the HbA1c level between two groups.
Conclusions
OHPP superiorly contributes to the improvement of oral health and oral microbiota in elderly diabetic patients. The overarching goal is to introduce attention to the importance of good oral health as a crucial point in preventing and managing diabetes mellitus and thereby contribute to the wellbeing and quality of life in people with diabetes.
Trial registration:
Chinese Clinical Trial Register number ChiCTR2200064453.
Bone and muscle mass characteristics in patients with gastroenteropancreatic neuroendocrine neoplasms
Authors: Aktypis Charalampos , Yavropoulou Maria P. , Efstathopoulos Efstathios , Polychroniadou Despoina , Papatheodoridis George , Kaltsas Gregory
Published: December 2024

Neuroendocrine neoplasms (NEN) are rare tumors arising from neuroendocrine cells most commonly in the gastrointestinal-tract. In recent years, advancements in therapeutics have increased survival rates in patients with NEN leading to a greater clinical burden compared to the general population.
The aim of this single-center case-control study was to investigate the incidence of low bone mass and changes in body-composition in adult patients diagnosed with gastroenteropancreatic-neuroendocrine tumors (GEPNET).
Enrolled participants underwent measurements of bone mineral density (BMD) at the lumbar-spine (LS), femoral-neck (FN), and total-hip (TH) and body-composition analysis with calculation of total fat-mass (TFM) and relative-skeletal-mass-index (RSMI), by Dual-X-Ray absorptiometry.
Ninety GEPNET, patients (28 with Pancreatic-NET; 20 with small-intestine-NET, 42 with gastric-NET), and 50 age and sex-matched controls were enrolled. The mean disease-duration was 5±4.4 years, the majority of patients (54/90) was classified as stage-1, and were not receiving systemic-treatment (76/90). The incidence of osteoporosis/osteopenia was 3-fold higher in the patients'-cohort, compared to controls (OR: 3.17 95%CI 1.16-7.8, p<0,001). Amongst NEN patients GNEN had the lowest bone mass, especially in LS. In addition, GEPNET patients demonstrated significantly lower TFM and RSMI, compared to controls (TFM: 31.6±9.6kg vs. 88.6±8.8kg, respectively p<0.001; RSMI: 6.4±1.1 vs. 8.2±0.6, respectively, p<0.001). Within our patients'-cohort, RSMI was significantly associated with LS-BMD (rho=0.448,p<0.001) and TH-BMD (rho=0.582,p<0.001), and TFM was associated with TH-BMD (rho=0.338,p=0.002).
Patients with GEPNET even at an early stage, exhibit significantly lower bone, muscle and fat-mass compared to the non-NET population, highlighting the importance of life-long monitoring of the musculoskeletal system in these patients.
Factors Associated with Patient and Health Care System Delay Among Migrant and Local Tuberculosis Patients in Istanbul: A Cross-Sectional Study
Authors: Ersözlü Mustafa , Lahmuni Mahmut , Mdal Yasser , Shammoot Moamen , Şen Hatice , Hoşnuter Ahmet Ferit , Giakoup Derya , Karaketir Emine Şeyma , Kılıçaslan Zeki
Published: December 2024

Background
Effective tuberculosis (TB) management requires timely diagnosis and immediate treatment initiation. The urgency for diagnosing and treating TB is particularly acute among immigrants, who face heightened health risks due to factors such as poverty, hazardous working conditions, and limited healthcare access. The objective of this study was to examine the characteristics of patient and health care delays among migrant and local TB patients in Istanbul and to identify factors associated with delays in the diagnosis and treatment of TB in both migrant and local patients.
Methods
This cross-sectional study was conducted in six Tuberculosis Control Dispensaries (TCDs) in Istanbul, the city with the highest number of TB cases in Turkey. A total of 211 TB patients, including 140 local residents and 71 migrants, participated. Data were collected through interviews via a structured questionnaire and patient files, following the patients' consent.
Results
Among migrant patients, the time from the onset of TB-related symptoms to admission to a health institution (patient delay) was 4.7 times longer (95% Confidence Interval [CI] = 1.1–20.9) than that in local resident patients. Compared with local patients, migrant patients were predominantly male, younger, had lower education levels, had a history of previous TB, and were less likely to smoke. Additionally, the frequency of working without insurance and unemployment was greater among migrant patients than among those employed with insurance.
Conclusion
Our research underscores the importance of focusing on the migrant community to achieve tuberculosis control goals, potentially through interventions to increase knowledge of healthcare system access and the significance of working conditions, including health insurance. While we profiled migrant TB patients, qualitative research is needed to elucidate the underlying reasons for delays in diagnosis and treatment.
Translation and Psychometric Validation of the Heart Failure Symptom Tracker (HFaST)
Authors: Perez Maria Inês , Seringa Joana , Magalhães Teresa
Published: December 2024

Background: Heart Failure (HF) is a global public health issue with high morbidity and mortality rates. Symptom management improves HF patients’ quality of life and demonstrates a potential reduction in hospitalisation, particularly among individuals aged 65 and over. This study aimed to translate, cross-culturally adapt and evaluate the psychometric properties of the Heart Failure Symptom Tracker (HFaST) tool for the Portuguese population. Additionally, it aimed to test the hypothesis that higher scores of the HFaST are associated with increased hospitalisations due to HF decompensation.
Methods: This cross-sectional study was conducted in two phases. The first phase involved the linguistic translation and cross-cultural adaptation of the HFaST tool into European Portuguese. Content validity was assessed by a panel of ten experts, who evaluated the clarity, relevance and equivalence of the pre-final version. A pre-test, using cognitive interviews with a sample of forty individuals was conducted to assess the item comprehensibility of the adapted tool. The second phase involved the psychometric validity in a sample of sixty HF patients. Participants completed a demographical and clinical assessment, the Portuguese version of the HFaST tool and the Portuguese version of the KCCQ-23 questionnaire. Additionally, the association between HFaST scores and HF hospitalisations were analysed.
Results: Equivalence between versions showed substantial to perfect agreement, with Fleiss’ k ranging from 0.678 to 1.000. Necessary adjustments were performed. Pre-test confirmed 95% comprehensibility. Internal consistency was acceptable, with a Cronbach’s Alpha of 0.724, moderate to strong inter-item correlations, and significant correlations between the HFaST and the KCCQ-23 items were observed. Additionally, higher HFaST scores were significantly associated with an increased likelihood of hospital admission.
Conclusions: The Portuguese version of the HFaST demonstrated to be a reliable and valid self-management tool for HF patients in Portugal, enhancing symptom monitoring and potentially reducing hospital admissions, thus improving patients’ quality of life.
Clinical Trial Number: not applicable.
Based on CT scans at the 12th thoracic spine level, the skeletal muscle index is independently associated with one-year postoperative mortality in elderly hip fracture patients: a propensity score-matched multicenter retrospective study
Authors: Li En-Li , Huang Cheng-Bin , Chen Zi-Hao , Jin Chen , Ma Run-Xun , Feng Si-Xiang , Yang Lei
Published: December 2024

Background: Research has demonstrated that individuals with sarcopenia or sarcopenic obesity who experience fractures or undergo major surgical interventions exhibit a poorer prognosis compared to the general population. However, few studies have investigated the relationship between the skeletal muscle and adipose tissue indices, as measured at the 12th thoracic spine level, and adverse outcomes following orthopedic surgery. Therefore, this study aimed to prove whether skeletal muscle and adipose tissue index measured by computed tomography (CT) images based on a single layer are associated with one-year postoperative mortality in elderly hip fracture patients.
Methods: A total of 334 participants from two institutions were enrolled in this study to obtain skeletal muscle index (SMI), subcutaneous fat index (SFI), visceral fat index (VFI), and the visceral-to-subcutaneous ratio of the fat area (VSR) at T12 levels and divide them into death and survival groups based on the results of follow-up after 1 year. Propensity score matching (PSM) was employed to evaluate one-year postoperative mortality.
Results: Institution 1's results identified that a lower SMI significantly heightened the risk of one-year postoperative mortality (OR=0.799,95%CI 0.677-0.943，P=0.008), making SMI an independent predictor. Institution 2's results identified that age (OR=1.081, 95%CI 1.005-1.163，P=0.036), SMI (OR=0.881, 95%CI 0.784-0.991，P=0.035) as independent predictors of one-year postoperative mortality in elderly hip fracture. Receiver operator characteristics analysis revealed area under the curve (AUC) values for institution 1: SMI (0.738 (95%CI 0.626-0.851), significant), VFI (0.605 (95%CI 0.476-0.734)), VSR (0.583 (95%CI 0.451-0.715)); and for institution 2: SMI (0.742 (95%CI 0.612-0.872), significant) and Age (0.775 (95%CI 0.677-0.874), significant). Collectively, these results underscore that SMI serves as an independent predictor of one-year postoperative mortality in elderly hip fracture patients.
Conclusion: This study demonstrated that the T12-based SMI was independently associated with one-year mortality following hip fracture in geriatric patients, with lower preoperative SMI correlating with higher mortality rates post-surgery.