bluuebunny/crossref_metadata_2025 huggingface dataset:
Tingkat Stres Mahasiswa Pada Pembelajaran Luring Masa Pandemi COVID-19
Authors: Simbolon Idauli , Limbong Albinur
Published: October 2022

Artikel ini adalah sebuah studi tentang tingkat stres mahasiswa pada pembelajaran offline (luring) pada permulaan semester Ganjil 2022/2023. Sejak awal pandemic COVID-19 model pembelajaran di UNAI berubah dari luring, sebelum pandemik, menjadi daring, pada awal pandemik, kemudian berubah menjadi pembelajaran hybrid (daring dan luring) setelah 1 tahun pandemik, kemudian kembali menjadi luring mulai semester ganjil 2022/2023. Perubahan model pembelajaran ini perlu diteliti dampaknya terhadap tingkat stres mahasiswa UNAI. Populasi dalam penelitian ini adalah semua mahasiswa yang mengikuti pembelajaran luring pada bulan pertama semester ganjil 2022/2023, berjumlah 1411 orang. Dari populasi kemudian ditentukan sampel berjumlah 97 orang, yang diambil secara acak, yang mewakili semua fakultas, tahun masuk dan jenis kelamin. Hasil penelitian menunjukkan bahwa tingkat stres mahasiswa UNAI termasuk dalam kategori rendah. Tidak ada perbedaan yang signifikan tingkat stres antara 6 fakultas yang ada di UNAI. Tingkat stres juga tidak berbeda signifikan antara mahasiswa baru dengan mahasiswa lama, antara laki-laki dan perempuan, dan antara mahasiswa yang mengambil sedikit mata kuliah (SKS) dengan mereka yang mengambil banyak SKS. Program-program akademik dan ekstrakurikuler yang dilakukan di kampus UNAI, sebagai kampus berasrama, berkontribusi terhadap rendahnya tingkat stress yang dialami oleh mahasiswa pada awal semester pembelajaran luring.
Assessing Mogadishu Banadir Children and Mother Hospital Healthcare Workers’ Knowledge of Exclusive Breast Feeding and Complimentary Feeding
Authors: Farah Abdiqani Ahmed , Mohamed Najma Ali , Iman Mohamed Ismael
Published: October 2022

The aim of this study is to assess the medical as well as voluntary staff expertise and awareness on the importance of exclusive breastfeeding and complementary feeding and system-level barriers that prevent families and communities from getting lactation assistance that might have impacted upon breastfeeding practices altogether. A cross-sectional survey was conducted to recruit a random sample of the staff working in the different units. All were interviewed through a structured questionnaire which included their knowledge, attitudes, and beliefs regarding their skill and awareness of the matter. Descriptive as well as inferential statistics (t-test, ANOVA, and Chi-square) were employed to obtain results and their significance. The significant demographic characteristics of participants indicate that 50% were 25–35 years old, 62.5% were female, 25% were single, 50.0% were university graduates, and almost half (45%) had been full-time employees of the hospital. The staff overwhelmingly recognised that the first yellowish colostrum should be fed to the baby and the potential benefits the baby gains from the mother’s milk, such as nutrition, getting antibodies and reducing the risk of disease. Also, the maternal benefits such as reduced breast cancer and increased postpartum emotional health. In addition, the response was sweepingly positive when it came to nursing and supplemental feeding lower child morbidity and mortality. The practices that may prevent early mother-and-baby contact range from requiring the mother to lie in bed during labour and delivery to drug-induced sleep. The respondents believed that all factors contributed. With the intention of protecting every parent’s and child’s human right to breastfeed, it is vital that high-quality breastfeeding education be implemented across the health service providers (hospitals) and the entire spectrum of medical education in the country. This will facilitate future medical staff to acquire the knowledge, abilities, and attitudes necessary to practice medicine and will also help practising doctors keep their skills and competency up-to-date.
Ligustrazine Alleviates Kidney Injury in a Rat Model of Uremia via Attenuation of Wnt/β-Catenin Signaling Pathway
Authors: Guan Xi , Guo Shanmai
Published: October 2022

Uremia is associated with kidney injury and contributes to chronic renal failure. Ligustrazine, a bioactive alkaloid from traditional Chinese herb Ligusticum wallichii Franchat, exerts renal-protective effect against acute kidney injury. The role of ligustrazine in uremia-associated kidney injury was investigated. To induce uremia, rats were subjected to 5/6 nephrectomy and intravenously administered with saline. Survival rate of rats was decreased by 5/6 nephrectomy, and levels of blood urea nitrogen, serum creatinine, and 24 h urine protein were elevated. Daily administration of ligustrazine to these rats increased the survival rate and reduced levels of blood urea nitrogen, serum creatinine, and 24 h urine protein output. Moreover, analysis of kidney histology showed that ligustrazine also ameliorated pathological changes in kidney. Finally, ligustrazine reduced levels of proinflammatory cytokines and suppressed renal apoptosis in the kidney tissues of uremic rats. In addition, ligustrazine downregulated protein expression of Wnt1 and β-catenin and inhibited nuclear distribution of β-catenin in uremic rats. In conclusion, ligustrazine protects rats against uremia-associated kidney injury and renal inflammation through inactivation of Wnt1/β-catenin pathway.
PENGARUH KEGIATAN PEKAN AKSI RIAU ( PAR)TERHADAP MINAT PELAJAR RIAU UNGGUL
Authors: Yozanti Atessa , Nazhifah  , Sekar Sur Azizah  , Miftahul Jannah  , Rangga Rafsanjani  , Misliya
Published: October 2022

Program literasi yang selalu dikampanyekan pemerintah, berujung pada lahirnya kegiatan Pekan Aksi Riau. Pekan Aksi Riau merupakan wadah untuk menampung aksi dan potensi masyarakat, serta berguna untuk mewujudkan Sumber Daya Manusia yang unggul,terkhusus bagi para pelajar. Aksi dan potensi masyarakat yang hadir pada kegiatan Pekan Aksi Riau merupakan perwujudan keberhasilan pelaksanaan literasi. Dengan kegiatan Pekan Aksi Riau dikenalkan bahwa literasi itu bukan hanya membaca saja, tapi literasi juga tentang kreativitas dan inovasi seperti mengembangkan minat pelajar di provinsi Riau .Tujuan penelitian ini untuk mengetahui seberapa besar pengaruh kegiatan Pekan Aksi Riau terhadap minat pelajar Riau unggul. Penelitian ini menggunakan teori belajar social yang dikemukan oleh Bandura. Metode Penelitian ini yaitu metode kuantitatif eksplanasi. Teknik pengumpulan data menggunakan kuisoner online melalui google form. Jumlah sampel sebanyak 67 respon dengan menggunakan teknik random sampling. Untuk mengetahui seberapa besar pengaruh kedua variabel tersebut, peneliti menggunakan analisi regresi linear sederhana yang diolah menggunakan program Statistic Product And Service Solution (SPSS) Windows Versi 2.2. Hasil penelitian menunjukkan bahwa regresi Y= 20,592 + 0,575 X dengan tingkat signifikansi sebesar 0,000, lebih kecil dari α = 0,05, Artinya terdapat pengaruh PekanAksi Riau terhadap minat pelajar Riau unggul
Augmented ASC Network for Photo Voltaic Applications
Authors: M Kalarathi , J Gnanavadivel , K Jayanthi
Published: October 2022

This work uses a DC-DC converter that employs an Active Switched Capacitor (ASC) to provide high gain that makes it appropriate for the Photo Voltaic (PV) system. The transformer less converter with an ASC network consists of a capacitor and a diode that boosts voltage effectively. The well-liked converter operates effectually on both Continuous Conduction Mode (CCM) and Discontinuous Conduction Modes (DCM). The suggested topology of converter is easy to design, and it renders a less stress on auxiliary diode and capacitors. This preferred converter scheme is validated through MATLAB Simulink and the outcomes are confirmed using hardware prototype.
Regression Based Predictive Machine Learning Model for Pervasive Data Analysis in Power Systems
Authors: Sasikala Dr. K. , Jayakumar Dr. J. , Senthil Kumar Dr. A. , Chacko Dr. Shanty , Queen Dr. Hephzibah Jose
Published: October 2022

The main aim of this paper is to highlight the benefits of Machine Learning in the power system applications. The regression-based machine learning model is used in this paper for predicting the power system analysis and Economic analysis results. In this paper, Predictive ML models for two modified IEEE 14-bus and IEEE-30 bus systems, integrated with renewable energy sources and reactive power compensative devices are proposed and developed with features that include an hour of the day, solar irradiation, wind velocity, dynamic grid price, and system load. An hour-wise input database for the model development is generated from monthly average data and hour-wise daily curves with normally distributed standard deviations. A very significant Validation technique (K Fold cross validation technique) is explained. Correlation between Input and output variable using spearman’s correlation analysis using Heat maps. Followed by the Multiple Linear Regression based Training and testing of the Modified IEEE 14 and IEEE30 Bus systems for base load case, 10% and 20% load increment with the 5-fold cross validation is also presented. Comparative analysis is performed to find the best fit ML Model for our research.
Wireless Vehicle Deceleration Speed System (WVDSS)
Authors: Abu-Ein Suleiman Qasim
Published: October 2022

This work presents an analysis of the problem related to road safety, the idea is to introduce the importance of obtaining more seriousness with committing the traffic rules, and more safety for roads and vehicles. This work provides a system, which replaces the systematic road bump with a transmitter that sends a signal to the coming vehicle’s Electronic Control Unit (ECU). Wireless connection will be between the vehicle and the transmitter placed at the bump's supposed position, to send signals or waves to be received by the receiver in the vehicle’s ECU. It was found that this system will increase the commitment of drivers to traffic signals which control the speed of cars and limit their speed at the allowable speed limits.
Pelatihan Mewarnai : Peningkatan Kompetensi Pendidik PAUD (TK, RA,KB) Kabupaten Ngawi
Authors: Prasetiyo Eko , Endang Jumiarsih
Published: October 2022

The goal to be achieved in the implementation of community service regarding improving the competence of early childhood educators (TK, RA, KB) in Ngawi district is to introduce and understand the coloring process, so that it is expected to improve the quality of learning. The method or method used to carry out this activity is presentation. , demonstration and practice. This method is done so that the teachers have direct experience of making works while still being supervised by the presenters. The results achieved in this activity are batik handicraft products. On the other hand, the enthusiasm or enthusiasm of the participants in participating in the activity is a result that is quite proud of us as organizers and is an illustration that this activity is quite successful.

Keywords: Training, coloring, coloring techniques.
Workshop Pentingnya Pendidikan Bagi Manusia di Desa Pandean Karanganyar Kabupaten Ngawi
Authors: Binsa Ucik , Anita Solihatul Wahidah  , Sermila
Published: October 2022

The purpose of this Community Service activity is to socialize, provide knowledge and understanding about the importance of education for humans and provide motivation to PKK women as community leaders and cadres to implement and convey to local residents in Pandean Village, Karanganyar District, Ngawi Regency. This Community Service is a vehicle for the PIAUD Study Program to devote its knowledge.

The target audience for this Community Service is PKK women as community leaders and cadres to implement and convey to local residents in Pandean Village, Karanganyar District, Ngawi Regency. Participants who attended amounted to 45 people from the planned 60 people. The method of this activity is counseling and socialization which is packaged in the form of a workshop for 1 day regarding the delivery of material on human nature, human nature and the need for education, understanding education.

The implementation of Community Service activities in the form of workshops is supported by several factors that contribute a lot to the success of Community Service activities. The implementation is carried out by workshops, using the lecture method, namely presentation techniques, followed by question and answer discussions as a form of workshop activities. The results of the implementation of Community Service show the level of understanding of community service participants about the importance of education, participants are more aware of the importance of education and have high motivation to continue their education to a higher level.
Pendampingan Keterampilan Berbahasa Inggris Pemula Bagi Anak-anak Melalui Kegiatan English Club
Authors: Ayu Hidayah Sari Nurdiyanti , Ariana Nur Syafika , Marselliah Marselliah , Aswan Muhammad , Helmi Setyawan Farid
Published: October 2022

Pendampingan keterampilan berbahasa Inggris pemula bagi anak-anak melalui kegiatan English Club yang dilaksanakan oleh tim PKMPM Program Studi Pendidikan Bahasa Inggris FKIP Universitas Borneo Tarakan ini dilaksanakan di Panti Asuhan Hidayah Nurul Yaqin. Dalam kegiatan ini yang menjadi subjek atau partisipan adalah anak-anak yang tinggal di Panti Asuhan Hidayah Nurul Yaqin yang berjumlah sebanyak 14 anak pada usia sekolah dasar hingga awal sekolah menengah. Pendampingan ini bertujuan untuk memberikan keterampilan dan kemampuan dalam berbahasa Inggris untuk anak-anak panti asuhan.  Metode pengumpulan data yang tim gunakan untuk mengumpulkan data berupa observasi, dokumentasi, angket, dan wawancara. Adapun kesimpulan yang dapat ditarik dari pelaksanaan kegiatan English Club ini adalah tercapainya tujuan tim PKMPM dengan anak yang mengikuti kegiatan yaitu kemampuan berbicara bahasa inggris mereka yang meningkat dan dapat diterapkan dalam kehidupan sehari-hari.
A Study on Acid Hydrolysis and Composition of Polysaccharides Concentrated from Coconut Kernel
Authors: Yalegama Loku Liyana Waduge Chandi , Karunaratne Desiree Nedra , Sivakanesan Ramaiah
Published: October 2022

Defatted dehydrated coconut kernel powder (DDCP) is the by-product obtained from virgin coconut oil production through dry process. The aim of the study was to concentrate polysaccharides from DDCP and to investigate their acid hydrolysis capacity and the monosaccharides composition. Residual fat, protein and soluble sugars of DDCP were removed to concentrate coconut kernel Insoluble polysaccharides (CKIP) while water extract of DDCP was used to concentrate coconut kernel soluble polysaccharides (CKSP). Neutral detergent solution (NDS) was used to concentrate neutral detergent soluble polysaccharides (NDSP) and neutral detergent insoluble polysaccharides (NDIP) from CKIP. The acid detergent solution (ADS) was used to concentrate acid detergent soluble polysaccharides (ADSP) and acid detergent insoluble polysaccharides (ADIP) from CKIP. Results indicated fresh coconut kernel contained 7.2±1.5% carbohydrates and the content increased to 78.1±1.3% with the removal of residual fat, protein and sugars. The yields of the polysaccharide fractions were 46.0±3.1% (CKIP) and 9.2± 0.1% (CKSP), 10.2±0.3% (NDSP) and 78.3±4.2% (NDIP), 25.1±0.3% (ADSP) and 45.2±2.9% (ADIP). Trifluoracetic acid had a higher hydrolyzing capacity than sulphuric acid except for hydrolyzing of ADIP. The monosaccharides composition of the polysaccharides was significantly different (p<0.05) among the polysaccharide concentrates. The main monosaccharides in NDSP were glucose (73.86%) and xylose (19.7%) and, in ADSP were rhamnose (33.45%) and glucose (46.91%). Rhamnose (29.95%) arabinose (26.38%), xylose (21.56%) and mannose (12.87%) were present in CKSP while mannose (68.46%), galactose (20.59%) and xylose (10.59%) were present in CKIP. Results indicated that soluble polysaccharides of coconut kernel were hydrolyzed into monosaccharides readily compared to the insoluble polysaccharides.
SISTEM PENDUKUNG KEPUTUSAN PENENTUAN CALON PENERIMA BEASISWA MENGGUNAKAN METODE ANALYTICAL HIERARCHY PROCESS
Authors: Hakam Arya , Mulyana Wide , Syahril
Published: October 2022

Universitas Muhammadiyah Riau merupakan sebuah intansi yang bergerak di bidang pendidikan yang berjalan sudah 12 tahun. Dalam proses Pendidikan terhadap mahasiswa pihak Univeritas Muhammadiyah Riau juga membantu dalam penyaluran beasiswa dari Pemerintah Provinsi Riau yaitu beasiswa Bidikmisi (Biaya Pendidikan Mahasiswa Miskin Berprestasi). Permasalahan yang sering muncul ketika melakukan penyeleksian calon penerima beasiswa yaitu terjadi kesulitan dalam penyeleksian calon penerima mahasiswa dengan kondisi banyaknya mahasiswa yang mendaftar beasiswa dengan kriteria yang banyak sehingga penyeleksian kurang mendetail dan Ketatnya persaingan antara mahasiswa dan tipisnya perbedaan kondisi mahasiswa sehingga menyulitkan pemberian beasiswa yang lebih tepat sasaran. Untuk mengurangi terjadinya kesalahan dalam pemberian beasiswa yang kurang tepat dan membuat data penyeleksian beasiswa lebih tersistemisasi maka dibutuhkan sebuah sistem pendukung keputusan sebagai alat bantu bagi para pengambil keputusan dengan menambahkan kebijaksanaan manusia menggunakan metode Analytical Hierarcy Proces (AHP) sehingga meringankan pekerjaan tim penyeleksi yang dilakukan setiap program studi. Hasil yang dicapai dalam pengimplementasian sistem pendukung keputusan ini yaitu dapat merekomendasikan calon penerima beasiswa dimana tampilan data mahasiswa calon beasiswa pada sistem diurutkan dari nilai terbesar hingga terkecil dengan status rekomendasi apabila nilai mencapai standar yang telah ditentukan.
Perancangan Sistem Point Of Sale Pada Jelly Potter Ciapus Bogor Berbasis Android
Authors: Aprian Novi , Syarief Hidayatullah Reko , Julaeha Siti
Published: October 2022

Technology can make work more efficient, data collection of product stocks and transactions at Jelly Potter Ciapus Bogor requires good management. Processing of product stock data and transactions still uses manual methods which causes slow processing of unstructured data. Overcoming the problem of slowness and data accuracy, the Point Of Sale system design for Jelly Potter Ciapus Bogor was based on android, software development aims to facilitate the data collection process. The research method used by the author in making this system is Research and Development (R&D) because this method is considered more effective in reviewing ongoing business processes. In the process of collecting data the author uses several methods of data collection, including: field studies and library methods. The design of this system is done by creating a model that explains each activity in detail using the Unified Modeling Language (UML). The results of the research are expected to be better in the data collection process, data storage is neater, and reporting is easily accessible because it is via mobile.
Sistem Informasi Smart Security untuk Perumahan dengan QR Code Berbasis Web
Authors: Deden Rahmat S Asep
Published: October 2022

This information system aims to make it easier for security officers to record residents who enter or leave the housing. This information system helps the housing admin get data on residents who enter and leave housing. There is no data collection system available for residents who will enter or leave the Graha Bakti Persada housing area. The unavailability of a support system that can be used as an effort to prevent crime. Building a Smart Security Information System with a web-based QR Code. Create a system that makes it easier for security officers. see the QR Code results based on the appropriate citizen ID in the database. The research methodology is to analyze the problems that occur, and design procedures. Suggestions that can be used as a reference for further system developers are the need to improve functions and menus in the application.
Perancangan Sistem Informasi E-Arsip Pada Kantor Kementerian Agama Kota Palembang Menggunakan Metode Prototype
Authors: Bahriyanto  , Dian Hafidh Zulfikar
Published: October 2022

Arsip merupakan rekaman sumber informasi berupa surat ataupun proposal yang berguna untuk instansi. Namun adanya instansi-instansi yang belum menerapkan kelajuan teknologi khususnya pada pengelolaan arsip. Banyak instansi melakukan pengelolaan arsip secara manual yang berkemungkinan dapat muncul bebagai permasalahan yang berkaitan dengan wadah penyimpanan, waktu, fasilitas, tenaga maupun faktor lain yang dapat mengakibatkan adanya kerusakan pada bidang arsip tersebut. Pada pengamatan ini bertujuan merancang sistem informasi pengarsipan secara elektronik di Kantor Kementerian Agama Kota Palembang. Pengamatan ini dilakukan dengan menggunakan dua buah metode yaitu dengan penggunaan metode untuk pengumpulan data dan metode Prototype. Berdasarkan hasil dari pengamatan maka didapatkanlah  desain prototype perancangan sistem informasi e-arsip yang meliputi rancangan dalam pembuatan halaman login, rancangan halaman dashboard, rancangan halaman tampilan surat masuk, rancangan halaman tambah surat masuk, dan rancangan halaman surat keluar. Maka daripada itu diharapkan dengan adanya perancangan ini dapat membantu dalam pembuatan sistem pengarsipan secara digital dan pengelolaan arsip di Kantor Kementerian Agama Kota Palembang.
THE ECOLOGICAL CONCERNS IN THE POST-APOCALYPTIC WORLD OF MARGARET ATWOOD’S THE YEAR OF THE FLOOD
Authors: Joshi Jagdish , Solanki Milind
Published: October 2022

Humans have strived for their presence on this planet and have strongly believed in their superiority over other animals. The quest for humans own individuality has led them to acquire more, whether its knowledge, land, natural resources or in general the planet to. This superiority complex of humans has led to the destruction and extinction of many species on this planet. Since last two centuries humans have advanced rapidly compared to last two thousand years. We have progressed and reached Mars but the question is about our own planet and the living beings on this earth. Human’s quest in space is for the existence of the question; are we alone? But at the same time the ecology of this planet is also unique. This paper explores the ecological concerns as portrayed in The Year of the Flood.
PENETAPAN KADAR FLAVONOID TOTAL DAN NILAI SUN PROTECTION FACTOR (SPF) FRAKSI EKSTRAK ETANOL DAUN CEMPEDAK (Artocarpus integer)
Authors: Sari Anna Khumaira , Muhammad Ikhwan Rizki  , Syifa Auliani  , Normaidah  , Amalia Khirunnisa
Published: October 2022

Daun Cempedak (Artocarpus integer) merupakan salah satu tumbuhan yang diketahui memiliki kandungan senyawa flavonoid dan berpotensi digunakan sebagai tabir surya. Penelitian ini bertujuan untuk menentukan kadar flavonoid total dan aktivitas tabir surya fraksi ekstrak etanol daun A. integer dengan menggunakan instrumen spektrofotometer UV-Vis. Daun A. integer segar dilakukan proses ekstraksi secara maserasi dengan pelarut etanol 96 %. Ekstrak kering difraksinasi dengan n-heksan dan etil asetat serta fraksi diuapkan hingga kental. Penentuan kadar flavonoid dilakukan dengan metode kolorimetri AlCl3, sedangkan uji Sun Protection Factor (SPF) dilakukan pada konsentrasi 200, 400, 600, 800, dan 1000 ppm menggunakan instrumen spektrofotometer UV-Vis. Hasil menunjukkan kadar flavonoid total fraksi ekstrak etanol daun A.integer yaitu fraksi n-heksan 1,565 ± 0,007 % b/b, fraksi etil asetat 2,443 ± 0,035 % b/b, dan fraksi air 0,560 ± 0,002 % b/b ekivalen kuersetin. Aktivitas tabir surya fraksi ekstrak etanol daun A. integer yang paling baik terdapat pada konsentrasi 1000 ppm yaitu fraksi etil asetat termasuk kategori kuat dengan nilai SPF 8,511; fraksi n-heksan termasuk kategori sedang dengan nilai SPF 4,786; dan  fraksi air termasuk kategori sedang dengan nilai SPF 4,322.
Electroencephalographic evaluation in patients with impaired consciousness
Authors:   Neurology Department, University Emergency Hospital, Bucharest, Romania, Roceanu Adina , Mindruta Ioana ,   Neurology Department, University Emergency Hospital, Bucharest, Romania, Ene Amalia ,   Neurology Department, University Emergency Hospital, Bucharest, Romania, Copaciu Elena ,   Intensive Care Department, University Emergency Hospital, Bucharest, Romania, Bajenaru Ovidiu Lucian ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bajenaru Ovidiu Alexandru ,   Neurology Department, University Emergency Hospital, Bucharest, Romania, Tiu Cristina ,   Neurology Department, University Emergency Hospital, Bucharest, Romania
Published: October 2022

The electroencephalographic examination (EEG) records spontaneous electrical activity generated in the cerebral cortex. The EEG is abnormal in almost all conditions associated with impairment of the level of consciousness. When consciousness is impaired the EEG becomes slowed (episodic or continuous), unresponsive to afferent stimuli, amplitude diminishes until eventually becomes flat. Coma may have various causes. EEG is a diagnostic and prognostic tool in acute anoxic coma. EEG is the only diagnostic tool for detecting a non-convulsive epileptic status.
Neurocognitive disorder and dysgenesis of corpus callosum
Authors:   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Davidescu Irene ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Anton Ruxandra Maria ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Mihailescu Gabriela ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Parvu Delia ,   Hiperdia, Colentina Clinical Hospital, Bucharest, Romania, Nica Sanda Maria ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Buraga Ioan ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Popescu Bogdan O. ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Molecular Medicine, “Victor Babes” National Institute of Pathology, Bucharest, Romania
Published: October 2022

We report the case of a 68 year-old female (O.F.), referred to our clinic for a neurological evaluation after an episode of loss of consciousness that occurred three days before admittance. She was also diagnosed with cognitive impairment (July 2011). Case particularity: the MRI examination, which was the investigation of choice in this case, revealed structural brain abnormalities – dysgenesis of the corpus callosum.
Valproate induced subclinical hypothyroidism in children with epilepsy
Authors:   Department of Pediatric Neurology, “Dr. Victor Gomoiu” Children’s Hospital, Bucharest, Romania, Teleanu Raluca ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Matei Margarita ,   Endocrinology Ambulatory, “Dr. Victor Gomoiu” Children’s Hospital, Bucharest, Romania, Sandu Magdalena ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Nita Smaranda ,   Department of Pediatric Neurology, “Dr. Victor Gomoiu” Children’s Hospital, Bucharest, Romania
Published: October 2022

Stroke remains a leading cause of disability and mortality all over the world despite the efforts made towards improving treatment. Most of the clinical studies have not shown significant beneficial effects in the evaluation of various molecules for their neuroprotection and neuro-recovery promoting properties. The new concept of multimodal, pleiotropic drugs has opened new perspectives in this field. This review focuses on clinical stroke studies with biologically active molecules such as erythropoietin, granulocyte-colony stimulating factor and Cerebrolysin.
The incidence of visual subclinical manifestations in multiple sclerosis
Authors:   Ophtalmology Department, Emergency University Hospital of Bucharest, Romania, Grecescu Monica
Published: October 2022

Optic neuritis is often the initial manifestation in multiple sclerosis (15%). There is a significant percent of patients affected by clinically definite multiple sclerosis that report no ocular symptoms. Some of this patients complain of poor vision despite the 6/6 visual acuity with Snellen test. Subclinical visual abnormalities may be revealed by more sensitive measures of visual function. Alteration of visual evoked potential latencies associated with brain MRI lesion burden, standard achromatic perimetry and low-contrast letter acuity, may detect subclinical visual manifestations. In this study we compare the efficiency of electrophysiological test (visual evoked potential) and subjective tests (contrast sensitivity and standard achromatic perimetry) in detection of visual impairment in a population of asymptomatic patients with clinically definite multiple sclerosis. Purpose. The detecting of subclinical impairment of visual function in a population of visual asymptomatic patients affected by clinically definite multiple sclerosis (MS) by using visual evoked potentials (VEPs), contrast sensitivity (CS), standard achromatic perimetry (SAP), magnetic resonance imaging (MRI), color vision test Ishihara, best corrected visual acuity (BCVA). Methods. Eighteen eyes of nine patients affected by clinically definite MS, without visual disturbances and optic neuritis history. All the patients were recruited at the Department of Neurology of Emergency University Hospital of Bucharest. Of the nine patients, 3 were male and 6 female. In all the cases the disease was in remission. The tests used to detect the involvement of visual pathway were: • VEPs (a P100 latency >115 ms) • CS • SAP (abnormal MD or PD) • MRI (at least one demyelinating plaque along visual pathway) • Color test Ishihara • Best corrected visual acuity (BCVA) • Biomicroscopy • Ocular fundus examination after pupil dilatation. Results. From the 9 patients in the 29-47 year age group, VEPs was abnormal in 8 cases (88,8%), CS was abnormal in 8 cases (88,8%), SAP in 44,4%, color vision test Ishihara evidenced colour desaturation at 100% cases. Best corrected visual acuity, biomicroscopy and ocular fundus examination were normal in 55,5% cases. Conclusions. In patients affected by MS with no history of optic neuritis and no visual symptoms, there is large prevalence of visual pathway involvement that can be detected by performing multiple tests. Only a combination of CS, VEPs and SAP can detect most cases of visual dysfunction associated with MS.
Prognostic factors in hypertensive intracerebral hemorrhage - study on a group of 80 patients
Authors:   National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania, Ghelmez Dana ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Tuta Sorin ,   National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Popa Constantin ,   National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: October 2022

Introduction. Hypertensive cerebral hemorrhage remains a severe disease with a high mortality. Current therapeutic options (including surgery) are limited, therefore prognostic elements are important in selecting patients for the testing of more aggressive future therapies. Prognosis depends on the location of the lesion (supratentorial versus infratentorial), size of hematoma, state of the patient at admission (measured by GCS scale), patient age and associated comorbidities. Objective and method. Clinical and imaging correlations of various vital prognostic factors for ICH were evaluated (Glasgow Coma Scale, volume of hemorrhage, presence and volume of ventricular blood, location of bleeding, patient age). The hypothesis of integration of all these prognostic factors was tested and external validation of the ICH prognostic scores was tried. ICH score is one of the predictors for mortality at 30 days due to cerebral hemorrhage. We analyzed 80 patients with cerebral hemorrhage admitted to the National Institute of Neurology and Neurovascular Diseases Bucharest and we evaluated the independent prognostic factors above, but also integrated them into the ICH score which we correlated with the death rate. Results and conclusions. The deaths rate in the study group was 39%. The presence of intraventricular blood was associated with a higher death rate and this rate was directly proportional to the amount of intraventricular blood. ICH score was externally validated in this cohort study as a reliable prognostic method, relatively easy to use and accurate for vital risk assessment in patients with cerebral hemorrhage.
Auditory deprivation
Authors:   Otologic Surgery Department, Institute of Phono-Audiology and Functional ENT Surgery, Bucharest, Romania, Marinescu Andreea Natalia , Georgescu Madalina Gabriela ,   Audiology and Vestibulogy Department, Institute of Phono-Audiology and Functional ENT Surgery, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: October 2022

Prelingual deafness deprives the auditory cortices areas from the physiological stimulus which is mandatory for the normal anatomical and physiological development of the cortex. In the absence of immediate intervention appropriate for auditory habilitation, the auditory cortex will lose its specific capacity to process the auditory information. This phenomenon is known as auditory deprivation. Due to the cerebral plasticity, conventional hearing aids or cochlear implants use allow the reorganization of the cerebral auditory structures in order to regain their capacity to process correctly the sounds and the child to hear. Age of implantation is determinant for the benefit obtained by deaf children with cochlear implants. As soon as the implantation occurs, the acoustic exposure of the hearing impaired children increases as well. Early exposure to sounds allows the deaf child to understand speech better and to develop language better. Prelingually deaf children, implanted by the age of two, develop speech and language skills similar to their normal hearing peers.
The effect of erythropoietin on magnesium during ischemia reperfusion injury in rats
Authors:   Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece, Tsompos Constantinos , Panoulis Constantinos ,   Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece, Toutouzas Konstantinos ,   Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece, Zografos George ,   Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece, Papalois Apostolos ,   Exprerimental Research Center, ELPEN Pharmaceutical Co. Inc. S.A.
Published: October 2022

The aim of this experiment study was the erythropoietin testing, on rat model and particularly on ischemia reperfusion protocol. The benefit or the non effect of that molecule was studied biochemically on blood magnesium. Material and methods 40 rats were used of mean weight 247.7 g. Magnesium was measured on these time points: on 60 min after reperfusion (groups A and C), and on 120 min after reperfusion (groups B and D), A and B without but C and D with erythropoietin administration. Results were that 1) erythropoietin administration decreased non significantly the magnesium by 0.035 mg/dl (-0.2453171 mg/dl - 0.1753171 mg/dl) (P = 0.7381), in accordance also with paired t-test (P = 0.7116), 2) reperfusion time increased non significantly the magnesium by 0.135 mg/dl (-0.0709124 mg/dl - 0.3409124 mg/dl) (P = 0.1924), in accordance also with paired t-test (P = 0.1665), and 3) interaction of erythropoietin administration and reperfusion time decreased non significantly the magnesium levels by 0.0063636 mg/dl (-0.1333617 mg/dl -0.1206344 mg/dl) (P = 0.9197). Conclusions are that erythropoietin administration, reperfusion time and their interaction have miscellaneous and not significant effects on magnesium within short-term context of 2 hours. Perhaps, a longer study time may reveal some significant effect.
Creuzfeldt-Jakob's disease - case report
Authors:   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Cofoian-Amet Zela , Rusu Bogdan ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Mitu Cristina ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Rosianu Elena ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Popescu Bogdan Ovidiu ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania,   Department of Neurology, Psychiatry, Neurosurgery and Psychiatrics, School of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Laboratory of Neurosciences and Molecular Medicine, “Victor Babes” National Institute of Pathology, Bucharest, Romania
Published: October 2022

Creutzfeldt-Jakob disease is a low incidence progressive neurodegenerative disorder and, meanwhile, the most frequent human prion disease. We report here the case of a 65 years old female with a 2-month history of rapidly progressive dementia. The clinical examination identified patent cerebellar and extrapyramidal signs. Despite the absence of myoclonic jerks and pathological findings in T2 and FLAIR MRI, the presence of protein 14-3-3 in a significant amount in cerebrospinal fluid (CSF) was identified. The patient succumbed to the illness within 2 month of hospitalization.
Cardiac complications in acute stroke
Authors:   Neurologic Clinic, Emergency University Clinical Hospital, Bucharest, Romania, Nistor Raluca ,   University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania, Bajenaru Ovidiu ,   Neurologic Clinic, Emergency University Clinical Hospital, Bucharest, Romania,   University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania
Published: October 2022

Heart and brain have many connections both in physiology and disease. Most of literature refers to brain complications of heart disease. In this review we examine the cardiac complications seen in acute stroke, which are rather frequent in clinical practice, and need attention from both neurologist and cardiologist.
Advanced atherosclerosis and stroke in a young patient with cutaneous lymphoma
Authors:   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Cofoian-Amet Zela , Mitu Cristina ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Rosianu Elena ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Mujdaba-Elmi Ayghiul ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania, Popescu Bogdan O ,   Department of Neurology, Colentina Clinical Hospital, Bucharest, Romania
Published: October 2022

Atherosclerosis might begin in childhood with the development of fatty streaks. However, the advanced lesions of atherosclerosis, which complicate with ischemic events, are frequent rather in the elderly. We report here a case of early severe and symptomatic atheromatosis of large cervical vessels, in a young patient with some risk factors and strong familial history of vascular disease who was diagnosed with Sezary syndrome.
Ankylosing spondylitis and multiple sclerosis: a surprising parallel
Authors:   “Gr. T. Popa” University of Medicine and Farmacy, Iasi, Romania, Stamate Iulia Georgiana ,   Rheumatology Clinic, Rehabilitation Hospital, Iasi, Romania, Alexa Daniel ,   “Gr. T. Popa” University of Medicine and Farmacy, Iasi, Romania,   Neurology Clinic, Rehabilitation Hospital, Iasi, Romania, Ignat Bogdan ,   “Gr. T. Popa” University of Medicine and Farmacy, Iasi, Romania,   Neurology Clinic, Rehabilitation Hospital, Iasi, Romania, Popescu Cristian Dinu ,   “Gr. T. Popa” University of Medicine and Farmacy, Iasi, Romania,   Neurology Clinic, Rehabilitation Hospital, Iasi, Romania
Published: October 2022

Ankylosing Spondylitis (AS) and Multiple Sclerosis (MS) are two different chronic autoimmune and inflammatory diseases, one rheumatic and the other one neurological, apparently without any connection between them. Yet a few case reports proved that AS may be associated with MS and this situation should be considered in some epidemiological environment. Although the geographic map of incidence is approximately superposed for both entities there are only a few cases of association. Recent studies revealed that most loci associated with MS are located very close to or even within genes encoding molecules involved in immune system function, confirming the hypothesis that MS is a disease with immunologic mechanism. In addition, some of these loci are also associated at least with another autoimmune disease, thus reinforcing the idea that autoimmune diseases may have a common origin. If MS is more common in patients with AS than in the general population, we can speculate the existence of common factors involved in these diseases. Because of the limited number of cases that associated these two diseases, the correct diagnosis of both entities considered separately or together becomes mandatory especially reflecting on the anti-TNFα agents used to treat AS which may exacerbate or induce a latent MS or demyelination processes in the central nervous system. In terms of pathogenic mechanisms, they are poorly known in both diseases, but each is characterized by an initial immune and inflammatory attack, in MS the target is the myelin sheath and in AS the enthesis tissue. A case with association between the two diseases raises important issues in choosing an appropriate treatment.
The dual role of transforming growth factor beta in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis
Authors:   First Neurological Clinic, University of Medicine and Pharmacy, Targu-Mures, Romania, Balasa Rodica , Bajko Zoltan ,   First Neurological Clinic, University of Medicine and Pharmacy, Targu-Mures, Romania, Maier Smaranda ,   First Neurological Clinic, University of Medicine and Pharmacy, Targu-Mures, Romania, Motataianu Anca ,   First Neurological Clinic, University of Medicine and Pharmacy, Targu-Mures, Romania
Published: October 2022

Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that is involved in numerous pathological processes. TGF-β functions in the immune system are to perform the regulation of lymphocyte differentiation, survival and destruction. In autoimmune diseases of the central nervous system, like multiple sclerosis (MS) and the animal model of experimental autoimmune encephalomyelitis (EAE), depending on the context, TGF-β has paradoxically pro- and anti inflammatory effects, explaining the difficulties in creating therapeutic strategies targeting TGF-β. This review presents the progresses that have been made on the understanding of TGF-β in the pathogenesis of both EAE and MS.
Taking history for vertigo and dizziness - a practical approach
Authors:   Department of Neurology, University Hospital, Bucharest, Romania, Roceanu Adina , Muresanu Dafin F. ,   Department of Clinical Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Popescu Bogdan O. ,   Department of Neurology, Neurosurgery and Psychiatry, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Neurology, Colentina Clinical Hospital, Clinical Research Center, Bucharest, Romania, Anghel Daniela ,   Department of Neurology, Neurosurgery and Psychiatry, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Neurology, Fundeni Clinical Institute, Bucharest, Romania, Georgescu Madalina ,   Department of ENT Microsurgery, “Prof. Dr. Dorin Hociota” Institute for Phono-Audiology and Functional ENT Surgery, Bucharest, Romania, Cozma Sebastian ,   ENT Department, Rehabilitation Hospital, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Marceanu Luigi ,   Marzescu Clinical Hospital, Brasov, Romania, Albu Silviu ,   II-nd Department of Otolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Bajenaru Ovidiu ,   Department of Neurology, University Hospital, Bucharest, Romania,   Department of Neurology, Neurosurgery and Psychiatry, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: October 2022

Vertigo and dizziness are among the most frequent presenting symptoms, not only in neurology, but also in ENT and internal medicine clinics. Vertigo is a spinning sensation or the feeling that the surroundings are spinning. Floating sensation, light headiness, forward, backward – and sideward fall sensation, walking instability, gait hesitation or unsteadiness are other type of dizziness. Several clinical pictures of different etiologies include vertigo and dizziness as underlying complaint. Diagnosis should be based on clinical history and neurotological evaluation. A common perspective of neurologists, ENT doctors and general medicine physicians is needed for a better diagnosis and treatment of vertigo and dizziness patients.
Prevalence of non-motor symptoms in Parkinson's disease - an observational study
Authors:   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Vasile Titus Mihai , Roceanu Adina Maria ,   University Emergency Hospital, Bucharest, Romania, Antochi Florina ,   University Emergency Hospital, Bucharest, Romania, Bajenaru Ovidiu Alexandru ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: October 2022

Objectives. This study aim is to evaluate the prevalence of non-motor symptoms in Parkinson’s disease. Methodology. We conducted an observational study in a prospective approach on a cohort of 70 patients admitted with a diagnosis of Parkinson’s disease in the Neurology Department of the University Emergency Hospital Bucharest for pre-surgery assessment or referred for a consultation to the Outpatient Department of Neurology of the Central Military Emergency Hospital, “Carol Davila” in the last two quarters of 2007, using a technique based on questionnaire (NMSQuest). Results. Patients included in this study were generally elderly, with a long relative history of disease. They are mostly in the moderate stage of disease and used treatment regimens with combinations of drugs. Prevalence of some non-motor symptoms according to the answers of patients in NMS questionnaire (NMSQuest), like: depression, memory impairment sleep disturbances, sexual disturbances, “light head”, constipation was statistically significant high in our group of patients. Conclusions. Non-Motor Questionnaire (NMSQuest) can be a useful clinically tool for detecting the common nonmotor symptoms in patients with Parkinson’s disease. Prevalence of non-motor symptoms in Parkinson’s disease is high and require further evaluation of their impact on patient’s quality of life.