bluuebunny/crossref_metadata_2025 huggingface dataset:
HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma
Authors: Kang Bor-Hwang , Shu Chih-Wen , Chao Jian-Kang , Lee Cheng-Hsin , Fu Ting-Ying , Liou Huei-Han , Ger Luo-Ping , Liu Pei-Feng
Published: June 2019

Buccal mucosa squamous cell carcinoma (BMSCC) is one of major subsites of oral cancer and is associated with a high rate of metastasis and poor prognosis. Heat shock proteins (HSPs) act as potential prognostic biomarkers in many cancer types. However, the role of HSPD1 in oral cancer, especially in BMSCC, is still unknown. Through data analysis with The Cancer Genome Atlas (TCGA), we found the association of HSPD1 gene expression with tumorigenesis and poor prognosis in oral cancer patients. Our cohort study showed that higher HSPD1 protein level was associated with tumorigenesis and poor prognosis in BMSCC patients with lymph node invasion, suggesting that HSPD1 may be involved in tumor metastasis. Moreover, knockdown of HSPD1 induced E-cadherin expression and decreased the migration and invasion of BMSCC cells. In contrast, ectopic expression of HSPD1 diminished E-cadherin expression and promoted the migration/invasion of BMSCC cells. Further, HSPD1 regulated RelA activation to repress E-cadherin expression, enhancing the migration and invasion of BMSCC cells. Furthermore, HSPD1 protein level was inversely correlated with E-cadherin protein level in tumor tissues and co-expression of high HSPD1/low E-cadherin showed a significant association with poor prognosis in BMSCC patients. Taken together, HSPD1 might repress E-cadherin expression and promote metastatic characters of BMSCC cells for poor prognosis of BMSCC patients.
Exploring the EEG mu rhythm associated with observation and execution of a goal-directed action in 14-month-old preterm infants
Authors: Montirosso Rosario , Piazza Caterina , Giusti Lorenzo , Provenzi Livio , Ferrari Pier Francesco , Reni Gianluigi , Borgatti Renato
Published: June 2019

Electroencephalographic mu rhythm desynchronization is thought to reflect Mirror Neuron System (MNS) activity and represents an important neural correlate of the coupling between action execution and perception. It is still unclear if the MNS in human ontogeny is already available at the beginning of postnatal life and how early experience impacts its development. Premature birth provides a “natural condition” for investigating the effects of early, atypical extra-uterine experience on MNS. The main aim of the present study was to investigate whether the MNS activity is associated with prematurity. We compared the mu rhythm activity in preterm (PT) and full-term (FT) 14-month old infants during an action observation/execution (AO/AE) task. Mu rhythm desynchronization was computed over frontal, central, parietal and occipital regions. Both groups showed mu rhythm suppression in all the scalp regions during action execution. Different desynchronization patterns emerged during action observation. Specifically, FT infants showed mu suppression in the right frontal, bilateral parietal and occipital regions; whereas PT infants exhibited mu suppression only in the right parietal region. Overall, these preliminary findings indicate that an atypical extra uterine experience might have an impact on the MNS activity.
Creep in Primary Consolidation with Rate of Loading Approach
Authors: Bi Gang , Ni Shuna , Wang Dong , Chen Yeqiang , Wei Jianfei , Gong Wenzong
Published: June 2019

The debate on creep in primary consolidation is analysed with a power law model following an approach in which creep is considered as rate of loading. According to this approach, primary consolidation is one type of rate of loading. To verify this approach, two types of tests, standard oedometer test and oedometer test with drainage prevented, are conducted on three types of soils (two from NGES and the other from Port of Guangzhou). The result: creep exponents obtained from two kinds of tests agree well with each other. Moreover, the approach is further validated by tracking, for over 80 years, the data from settlement of the case history San Jacinto Monument, which is inconsistent with data calculated from the classical method. In the end, procedure of this approach, with which long term settlement is predicted, is illustrated, and this approach is compared with the classical method.
Spin-locking metasurface for surface plasmon routing
Authors: Revah Matan , Yaroshevsky Andre , Gorodetski Yuri
Published: June 2019

Nanophotonic circuitry requires an ability to externally control and analyze optical signals tightly confined in subwavelength volumes. Various schemes of surface plasmon (SP) routing have been presented using active and passive metasurfaces. One of the most appealing approaches is the use of plasmonic spin-orbit interaction where the incident light spin state is efficiently coupled to an orbital degree of freedom of the surface wave. Recently, a major attention has been drawn to an additional plasmonic degree of freedom - the transverse spin and some application for near-field plasmonic manipulations have been presented. Here we propose a spin-locking metasurface incorporating a transverse spin of the SP wave to selectively route the near-field beams. Owing to the combination of the oblique incidence of circularly polarized light with the accurately designed momentum matching of the grating we achieve a precise directional control over the plasmonic distributions. The experimental verification of the directional launching is performed by a time-resolved leakage radiation measurements allowing one to visualize the shape and the dynamics of the excited beam.
On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug
Authors: López-Velázquez Gabriel , Fernández-Lainez Cynthia , de la Mora-de la Mora José Ignacio , Caudillo de la Portilla Daniela , Reynoso-Robles Rafael , González-Maciel Angélica , Ridaura Cecilia , García-Torres Itzhel , Gutiérrez-Castrellón Pedro , Olivos-García Alfonso , Flores-López Luis Antonio , Enríquez-Flores Sergio
Published: June 2019

Research onGiardia lambliahas accumulated large information about its molecular cell biology and infection biology. However, giardiasis is still one of the commonest parasitic diarrheal diseases affecting humans. Additionally, an alarming increase in cases refractory to conventional treatment has been reported in low prevalence settings. Consequently, efforts directed toward supporting the efficient use of alternative drugs, and the study of their molecular targets appears promising. Repurposing of proton pump inhibitors is effectivein vitroagainst the parasite and the toxic activity is associated with the inhibition of theG. lambliatriosephosphate isomerase (GlTIM) via the formation of covalent adducts with cysteine residue at position 222. Herein, we evaluate the effectiveness of omeprazolein vitroandin situonGlTIM mutants lacking the most superficial cysteines. We studied the influence on the glycolysis ofGiardiatrophozoites treated with omeprazole and characterized, for the first time, the morphological effect caused by this drug on the parasite. Our results support the effectiveness of omeprazole againstGlTIM despite of the possibility to mutate the druggable amino acid targets as an adaptive response. Also, we further characterized the effect of omeprazole on trophozoites and discuss the possible mechanism involved in its antigiardial effect.
High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer
Authors: Enroth Stefan , Berggrund Malin , Lycke Maria , Broberg John , Lundberg Martin , Assarsson Erika , Olovsson Matts , Stålberg Karin , Sundfeldt Karin , Gyllensten Ulf
Published: June 2019

Ovarian cancer is usually detected at a late stage and the overall 5-year survival is only 30–40%. Additional means for early detection and improved diagnosis are acutely needed. To search for novel biomarkers, we compared circulating plasma levels of 593 proteins in three cohorts of patients with ovarian cancer and benign tumors, using the proximity extension assay (PEA). A combinatorial strategy was developed for identification of different multivariate biomarker signatures. A final model consisting of 11 biomarkers plus age was developed into a multiplex PEA test reporting in absolute concentrations. The final model was evaluated in a fourth independent cohort and has an AUC = 0.94, PPV = 0.92, sensitivity = 0.85 and specificity = 0.93 for detection of ovarian cancer stages I–IV. The novel plasma protein signature could be used to improve the diagnosis of women with adnexal ovarian mass or in screening to identify women that should be referred to specialized examination.
Automated subset identification and characterization pipeline for multidimensional flow and mass cytometry data clustering and visualization
Authors: Meehan Stephen , Kolyagin Gleb A. , Parks David , Youngyunpipatkul Justin , Herzenberg Leonore A. , Walther Guenther , Ghosn Eliver E. B. , Orlova Darya Y.
Published: June 2019

When examining datasets of any dimensionality, researchers frequently aim to identify individual subsets (clusters) of objects within the dataset. The ubiquity of multidimensional data has motivated the replacement of user-guided clustering with fully automated clustering. The fully automated methods are designed to make clustering more accurate, standardized and faster. However, the adoption of these methods is still limited by the lack of intuitive visualization and cluster matching methods that would allow users to readily interpret fully automatically generated clusters. To address these issues, we developed a fully automated subset identification and characterization (SIC) pipeline providing robust cluster matching and data visualization tools for high-dimensional flow/mass cytometry (and other) data. This pipeline automatically (and intuitively) generates two-dimensional representations of high-dimensional datasets that are safe from the curse of dimensionality. This new approach allows more robust and reproducible data analysis,+ facilitating the development of new gold standard practices across laboratories and institutions.
Biotinylation and isolation of an RNA G-quadruplex based on its peroxidase-mimicking activity
Authors: Li Wei , Zeng Weiwu , Chen Yi , Wang Fang , Wu Fan , Weng Xiaocheng , Zhou Xiang
Published: June 2019

The selective biotinylation of RNA G-quadruplexes can be used for pulling down RNA G-quadruplexes from an RNA mixture.
Nanopipettes: a potential tool for DNA detection
Authors: Wang Zhe , Liu Yichong , Yu Lei , Li Yunchuan , Qian Gongming , Chang Shuai
Published: June 2019

As a sub-group of solid-state nanopore, nanopipette shows great potential to develop into a platform for efficient and rapid DNA detection.
Validating an ion mobility spectrometry-quadrupole time of flight mass spectrometry method for high-throughput pesticide screening
Authors: Chen Xiu-Ping , Zhang Fang , Guo Yin-Long
Published: June 2019

The utility of adding ion mobility (IM) to quadrupole time of flight mass spectrometry (IM-QTOF MS) for highly effective analysis of multiple pesticides in complex matrices was evaluated.
Prussian blue nanoparticle-labeled aptasensing platform on graphene oxide for voltammetric detection of α-fetoprotein in hepatocellular carcinoma with target recycling
Authors: Zhang Bei , Ding Hao , Chen Qi , Wang Ting , Zhang Kunhe
Published: June 2019

A Prussian blue nanoparticle-based aptasensor was developed for enzyme-free voltammetric detection of AFP by using graphene oxide-modified gold-disk electrode.
X-ray fluorescence determination of Ni, Ti and Nb in memory alloys using solution and thin film samples with an internal standard
Authors: Tian L. F. , Dai Y. C. , Zou D. S. , Lei T. C. , Huang S. K.
Published: June 2019

Specimen for XRF analysis of high content of Ni, Ti and Nb in memory alloys, prepared by solution (a) and a filter paper disk (b).
In situ modification of silica with poly(vinyl alcohol) for normal-phase liquid chromatographic separation of bioactive compounds in traditional Chinese medicines
Authors: Wu Can , Xu Pingcui , Wang Xuping , Shou Dan , Wang Nani , Zhu Yan
Published: June 2019

Polyvinyl alcohol modified porous silica was firstly prepared by using an in situ coating process, which was applied as a normal phase liquid chromatographic column and separated nucleosides, anthraquinones and terpenoids in 10 TCM samples.
A biomimetic tarso-conjunctival biphasic scaffold for eyelid reconstruction in vivo
Authors: Xu Peifang , Gao Qi , Feng Xue , Lou Lixia , Zhu Tiepei , Gao Changyou , Ye Juan
Published: June 2019

A biphasic scaffold with bionic structure mimicking tarsus and conjunctiva was manufactured and evaluated in vitro and in vivo.
A novel molecular scaffold resensitizes multidrug-resistant S. aureus to fluoroquinolones
Authors: Panjla Apurva , Kaul Grace , Shukla Manjulika , Tripathi Shubhandra , Nair Nisanth N. , Chopra Sidharth , Verma Sandeep
Published: June 2019

A peptide-based molecule offers synergism with fluoroquinolones and their combination “resensitizes” fluoroquinolone-resistant strains of S. aureus, thus presenting a strategy for antibiotic potentiation against nosocomial infections.
Precise regulation of the selectivity of supported nano-Pd catalysts using polysiloxane coatings with tunable surface wettability
Authors: Wang Hongli , Gao Ziqian , Wang Xinzhi , Wei Ruiping , Zhang Junping , Shi Feng
Published: June 2019

The selective hydrogenation reactions can be realized via the surface modification of supported nano-Pd with tailorable wettability.
Changes in macrocyclic aromaticity and formation of a charge-separated state by complexation of expanded porphyrin and C60
Authors: Cha Won-Young , Ahn Ahreum , Kim Taeyeon , Oh Juwon , Ali Rashid , Park Jung Su , Kim Dongho
Published: June 2019

Significant changes of macrocyclic aromaticity in expanded porphyrins through C60 complexation were studied by 1H NMR spectroscopy and nucleus-independent chemical shift calculations.
Contemporaneous oxidation state manipulation to accelerate intermediate desorption for overall water electrolysis
Authors: Zhao Yongqiang , Jin Bo , Vasileff Anthony , Jiao Yan , Qiao Shi-Zhang
Published: June 2019

Simultaneous oxidation state engineering of Co, N and S for cobalt nitride and sulfide electrocatalysts is demonstrated to facilitate intermediate desorption for OER and HER, leading to efficient overall water electrolysis in a neutral buffer electrolyte.
Unravelling substitution effects on charge transfer characteristics in cocrystals of pyrene based donors and 3,5-dinitrobenzoic acid
Authors: Mandal Arkalekha , Rissanen Kari , Mal Prasenjit
Published: June 2019

Ambipolar to p-type semiconductivity switching with the change of the ⋯DADADA⋯ to ⋯ADDADD⋯ packing arrangement in charge transfer cocrystals of pyrene based donors is discussed.
Photodissociation and reaction dynamics
Authors: Orr-Ewing Andrew J.
Published: June 2019

This themed issue includes a collection of articles on photodissociation and reaction dynamics and marks the occasion of Professor Mike Ashfold's 65th birthday.
One-step synthesis and electrochemical performance of a PbMoO4/CdMoO4 composite as an electrode material for high-performance supercapacitor applications
Authors: Anitha Tarugu , Reddy Araveeti Eswar , Anil Kumar Yedluri , Cho Young-Rae , Kim Hee-Je
Published: June 2019

A bunch of PbMoO4/CdMoO4 nanocube-like structures exhibit superior specific capacitance and cycling stability to PbMoO4 and CdMoO4 electrodes.
Rhodium(iii) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies
Authors: Khan Taj-Malook , Gul Noor Shad , Lu Xing , Kumar Rajesh , Choudhary Muhammad Iqbal , Liang Hong , Chen Zhen-Feng
Published: June 2019

Two rhodium complexes Rh1 and Rh2 with isoquinoline derivatives were synthesized and characterized.
Interlayer grafting of kaolinite using trimethylphosphate
Authors: Machida Shingo , Idota Naokazu , Sugahara Yoshiyuki
Published: June 2019

We have demonstrated the interlayer grafting of kaolinite using trimethylphosphate (TMP) upon the reaction between MeO-Kaol as an intermediate and TMP at 150 °C under nitrogen atmosphere, via the intercalation of TMP between the layers of kaolinite.
Downsizing of robust Fe-triazole@SiO2 spin-crossover nanoparticles with ultrathin shells
Authors: Torres-Cavanillas R. , Lima-Moya L. , Tichelaar F. D. , Zandbergen H. W. , Giménez-Marqués M. , Coronado E.
Published: June 2019

Robust hybrid [Fe(Htrz)2(trz)](BF4)@SiO2 nanoparticles with reduced sizes (from ca. 90 to 28 nm) and ultrathin silica shells (<3 nm) have been obtained, presenting abrupt spin transition and reduced thermal hysteresis.
Recent developments in single-molecule toroics
Authors: Li Xiao-Lei , Tang Jinkui
Published: June 2019

An update overview of emerging single-molecule toroics (SMTs) is expounded to elucidate the strategy to design SMTs and ultimately inspire the seeking of SMTs with enhanced toroidal moment.
Room temperature phosphorescence of Mn(ii) and Zn(ii) coordination polymers for photoelectron response applications
Authors: Yang Xiao-Gang , Zhai Zhi-Min , Lu Xiao-Min , Zhao Ying , Chang Xin-Hong , Ma Lu-Fang
Published: June 2019

Mn(ii) and Zn(ii) based coordination polymers have been synthesized, which show different mechanism of room temperature phosphorescence and special photoelectron response performance.
Biohybrid photoheterotrophic metabolism for significant enhancement of biological nitrogen fixation in pure microbial cultures
Authors: Wang Bo , Xiao Kemeng , Jiang Zhifeng , Wang Jianfang , Yu Jimmy C. , Wong Po Keung
Published: June 2019

Enhanced nitrogen fixation and solar-to-chemical conversion of the photoheterotrophic Rhodopseudomonas palustris with surface coated CdS nanoparticles.
Highly active niobium-loaded montmorillonite catalysts for the production of 5-hydroxymethylfurfural from glucose
Authors: Qiu Guo , Huang Chongpin , Sun Xiuliang , Chen Biaohua
Published: June 2019

Niobium-loaded montmorillonite was employed as a highly efficient catalyst for the catalytic conversion of glucose to 5-HMF in a biphasic solvent.
On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome
Authors: Lyons Bronwyn J. E. , Strynadka Natalie C. J.
Published: June 2019

Targeting the T3SS injectisome using the anti-virulence strategy offers an alternative to antibiotic therapeutic approaches when dealing with resistance.