bluuebunny/crossref_metadata_2025 huggingface dataset:
New insight into improving the solubility of poorly soluble drugs by preventing the formation of their hydrogen-bonds: a case of dapsone salts with camphorsulfonic and 5-sulfosalicylic acid
Authors: Wu Yanhui , Hao Xiujia , Li Jianting , Guan Aiying , Zhou Zhengzheng , Guo Fang
Published: July 2021

The improved solubility of two salts of dapsone (DAP) was investigated from the view point of structures and hydrogen bonding.
In situ cleavage and rearrangement synthesis of an easy-to-obtain and highly stable Cu(ii)-based MOF for efficient heterogeneous catalysis of carbon dioxide conversion
Authors: Qin Lan , Pan Yu , Yu Lei , Huai Ranran , Yang Lu , Dou Yong , Zhou Zhen
Published: July 2021

A Cu(ii)-based MOF has been synthesized by the in situ cleavage and rearrangement solvothermal synthesis. This material exhibits highly stabilities and CO2 adsorption ability to catalyze cycloaddition of CO2 with epoxides efficiently.
Construction of a viologen-derived 2D material with photochromism, photoswitchable luminescence and inkless and erasable prints via sunlight irradiation
Authors: Li Zhao-Hao , Xue Li-Ping , Liu Si-Rui , Wang Si-Jin
Published: July 2021

A Zn(ii) material based on thiophenedicarboxylate and viologen derivative mixed ligands is synthesized. Thanks to pyridinium unit embedded in its structure, the material exhibits a rapid photochromic response via sunlight irradiation.
Tunable electronic and optical properties in buckling a non-lamellar B3S monolayer
Authors: Lu Shaohua , Cai Yiyuan , Hu Xiaojun
Published: July 2021

A previously unknown monolayer (h1-B3S) is predicted by the structure swarm intelligence method. The proposed structure possesses high visible and near-infrared light absorption and has satisfactory H2 storage capacity.
Heterogeneous photocatalyzed acceptorless dehydrogenation of 5-hydroxymethylfurfural upon visible-light illumination
Authors: Liang Wanying , Zhu Rui , Li Xinglong , Deng Jin , Fu Yao
Published: July 2021

Photocatalytic dehydrogenation of 5-hydroxymethylfurfural to 2,5-diformylfuran under visible-light illumination: complete conversion and high selectivity can be achieved without any oxidants, additives or any conventional hydrogen acceptors.
Towards understanding of delignification of grassy and woody biomass in cholinium-based ionic liquids
Authors: Mohan Mood , Choudhary Hemant , George Anthe , Simmons Blake A. , Sale Kenneth , Gladden John M.
Published: July 2021

Herein we report the dissolution mechanism of lignin in cholinium-based ionic liquids by molecular dynamics simulations. Multiple hydrogen bonds, longer HB lifetimes, and higher pKaof [Ch][Lys] makes it a better solvent for lignin than acidic ILs.
Slow magnetic relaxation and luminescence properties in neodymium(iii)-4,4,4-trifluoro-1-(2-naphthyl)butane-1,3-dionato complexes incorporating bipyridyl ligands
Authors: Vicente Ramon , Tubau Ànnia , Speed Saskia , Mautner Franz A. , Bierbaumer Florian , Fischer Roland C. , Massoud Salah S.
Published: July 2021

A new series of eight-coordinated Nd(iii) complexes derived from 4,4,4-trifluoro-1-(naphthalen-2-yl)butane-1,3-dionate and bi-pyridyl ligands revealed multifunctional molecular materials as photoluminescent single-molecule magnets (SMMs).
Iodine-mediated 1,2-aryl migration of primary benzhydryl amines
Authors: Du Yangxu , Hou Jiao , Lu Qing , Hao Wei , Yu Wenquan , Chang Junbiao
Published: July 2021

This iodine-mediated 1,2-aryl migration reaction of primary amines is transition-metal-free and operationally simple, and can be conducted on a gram scale.
Slight structural modulation around a pivotal bond: high impact on enantiomeric stability
Authors: Farran Daniel , Vanthuyne Nicolas , Bossa Giulia , Belot Vincent , Albalat Muriel , Jean Marion , Roussel Christian
Published: July 2021

Based on an atropisomeric scaffold, structural modifications around chiral axis allowed to establish structure-rotational barrier relationships.
Dual magnetic field and temperature optical probes of controlled crystalline phases in lanthanide-doped multi-shell nanoparticles
Authors: Ferreira Flavia de Sousa , de Morais Amanda Justino , Santos Calado Claudia Manuela , Iikawa Fernando , Couto Junior Odilon D. D. , Brunet Gabriel , Murugesu Muralee , Mazali Italo O. , Sigoli Fernando A.
Published: July 2021

Dual magnetic and temperature optical probes of hierarchically structured core@multi-shell nanoparticles with controlled crystalline phases: a magneto cubic core containing DyIII and a co-doped ErIII:YbIII: NdIII optical hexagonal shell.
Homo- and copolymerization of norbornene using tridentate IzQO palladium catalysts with dimethylaminoethyl as a side arm
Authors: Dong Jie , Wang Baiquan
Published: July 2021

Rigid IzQO–Pd catalysts were synthesized by Rh(iii)-catalyzed C–H/alkyne annulation and applied for the homo- and copolymerizations of norbornene with polar vinyl monomers.
Applying multi-scale silica-like three-dimensional networks in a PEO matrix via in situ crosslinking for high-performance solid composite electrolytes
Authors: Wu Jiawei , Chen Jing , Wang Xiaodong , Zhou Anan , Yang Zhenglong
Published: July 2021

The junctions formed between siloxane-terminated ether chains and silica nanowires can promote a three-dimensional enhanced network and significantly improve the electrolyte performance in rate and cycling tests of solid LFP cells.
Supramolecular polymorphism in aggregates of a boron-difluoride complex of peri-naphthoindigo via solvent- and pathway-dependent self-assembly
Authors: Debnath Indraneel , Roy Tirupati , Matern Jonas , Jansen Stef A. H. , Fernández Gustavo , Mahata Kingsuk
Published: July 2021

Supramolecular polymorphism, a rare phenomenon, has been demonstrated using BF2-coordinated peri-naphthoindigo.
Autonomous capillary microfluidic devices with constant flow rate and temperature-controlled valving
Authors: Li Lanhui , Westerbeek Eiko Y. , Vollenbroek Jeroen C. , de Beer Sissi , Shui Lingling , Odijk Mathieu , Eijkel Jan C. T.
Published: July 2021

PNIPAm (N-isopropylacrylamide) grafted PDMS capillary microfluidic device with constant flow rate and temperature-triggered stop valve function.
Influence of diluent concentration in localized high concentration electrolytes: elucidation of hidden diluent-Li+ interactions and Li+ transport mechanism
Authors: Perez Beltran Saul , Cao Xia , Zhang Ji-Guang , El-Khoury Patrick Z. , Balbuena Perla B.
Published: July 2021

Li+ ions jump between aggregated networks where Li–O interactions dominate via diluent-enriched phases.
Effects of side reactions on the kinetics of nanoporous gold formation revealed by real-time X-ray scattering during electrolytic dealloying
Authors: Welborn Samuel S. , Corsi John S. , Wang Lin , Lee Asaph , Fu Jintao , Detsi Eric
Published: July 2021

Simultaneous SAXS/WAXS studies elucidate passive surface film growth during formation of nanoporous gold by electrolytic dealloying in HClO4, but not in HNO3. This passive surface film hampers dealloying kinetics and slows ligament growth/coarsening.
Zn2+-Intercalated V2O5·nH2O derived from V2CTx MXene for hyper-stable zinc-ion storage
Authors: Zhu Xiaodong , Wang Wenjie , Cao Ziyi , Gao Shangpeng , Chee Mason Oliver Lam , Zhang Xiang , Dong Pei , Ajayan Pulickel M. , Ye Mingxin , Shen Jianfeng
Published: July 2021

The intercalated Zn2+ and abundant interfaces between the conductive V2CTx and ZnxV2O5·nH2O can weaken the electrostatic interactions and maintain a large lattice channel during cycling, thus reducing the activation energy of charge transfer.
Circularly polarized electroluminescence from an achiral fluorophore induced by co-assembly with chiral polymers
Authors: Geng Zhongxing , Zhang Yuxia , Zhang Yu , Li Yang , Quan Yiwu , Cheng Yixiang
Published: July 2021

In this paper, this chiral supramolecular co-assembly (R/S-P2-Bpy) can not only emit deep blue CPL (λem = 420 nm, |gem| = 0.042) in spin-coated films, but also act as an EML of a CP-EL device (λem = 418 nm, |gEL| = 0.021).
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease
Authors: Herbst Susanne , Lewis Patrick A.
Published: July 2021

Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601–607; Neuron 44, 595–600), and subsequent efforts to develop LRRK2 kinase inhibitors as a therapy for Parkinson's (Expert Opin. Ther. Targets 21, 751–753), elucidating the atomic resolution structure of LRRK2 has been a major goal of research into this protein. At over 250 kDa, the large size and complicated domain organisation of LRRK2 has made this a highly challenging target for structural biologists, however, a number of recent studies using both in vitro and in situ approaches (Nature 588, 344–349; Cell 182, 1508–1518.e1516; Cell 184, 3519–3527.e3510) have provided important new insights into LRRK2 structure and the complexes formed by this protein.
Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer
Authors: Haines Corinne N. , Wardell Suzanne E. , McDonnell Donald P.
Published: July 2021

Nearly 80% of all breast cancers are estrogen receptor positive (ER+) and require the activity of this transcription factor for tumor growth and survival. Thus, endocrine therapies, which target the estrogen signaling axis, have and will continue to be the cornerstone of therapy for patients diagnosed with ER+ disease. Several inhibitors of ER activity exist, including aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs), selective estrogen receptor degraders/down-regulators (SERDs), and ER proteolysis-targeting chimeras (ER PROTACs); drugs which differ in the mechanism(s) by which they inhibit this signaling pathway. Notwithstanding their significant impact on the management of this disease, resistance to existing endocrine therapies remains a major impediment to durable clinical responses. Although the mechanisms of resistance are complex and varied, dependence on ER is typically retained after progression on SERMs and AIs, suggesting that ER remains a bona fide therapeutic target. The discovery and development of orally bioavailable drugs that eliminate ER expression (SERDs and ER PROTACs) will likely aid in treating this growing patient population. All of the existing endocrine therapies were developed with the intent of inhibiting the cancer cell intrinsic actions of ER and/or with the objective of achieving extreme estrogen deprivation and most achieve that goal. A longstanding question that remains to be addressed, however, is how actions of existing interventions extrinsic to the cancer cells influence tumor biology. We believe that these issues need to be addressed in the development of strategies to develop the next generation of ER-modulators optimized for positive activities in both cancer cells and other cells within the tumor microenvironment (TME).
Roles of steroid receptors in the lung and COVID-19
Authors: Leach Damien A. , Brooke Greg N. , Bevan Charlotte L.
Published: July 2021

COVID-19 symptoms and mortality are largely due to its devastating effects in the lungs. The disease is caused by the SARS (Severe Acute Respiratory Syndrome)-CoV-2 coronavirus, which requires host cell proteins such as ACE2 (angiotensin-converting enzyme 2) and TMPRSS2 (transmembrane serine protease 2) for infection of lung epithelia. The expression and function of the steroid hormone receptor family is important in many aspects that impact on COVID-19 effects in the lung – notably lung development and function, the immune system, and expression of TMPRSS2 and ACE2. This review provides a brief summary of current knowledge on the roles of the steroid hormone receptors [androgen receptor (AR), glucocorticoid receptor (GR), progesterone receptor (PR), mineralocorticoid receptor (MR) and oestrogen receptor (ER)] in the lung, their effects on host cell proteins that facilitate SARS-CoV-2 uptake, and provides a snapshot of current clinical trials investigating the use of steroid receptor (SR) ligands to treat COVID-19.
Pricing and inventory control decisions in the stochastic hybrid production systems with multiple recovery options
Authors: Naseri Foruzan , Esmaeili Maryam , Seifbarghy Mehdi , Heydari Tahereh
Published: July 2021

Although pricing and inventory control are crucial decisions in each production system, these decisions are usually investigated separately. This paper considers pricing and inventory control decisions simultaneously in a hybrid production system. The hybrid production system has two recovery options, remanufacturing and refurbishing sites. The demand follows Poisson distribution, which depends on the sale price of each product. Returned products arrive according to a Poisson process. Each returned product can be remanufactured, refurbished, or disposed. The time to manufacturing, refurbishing, and remanufacturing a product also follows an exponential distribution. By modeling the system as a Markov chain, the long-run expected profit function is obtained in terms of the dispose-down-to level of returned products and the order-up-to level and the sale price of serviceable products. A three-dimensional state space of the Markov Chain dependent to the sale price is developed considering pricing and inventory control decisions simultaneously with remanufacturing and refurbishing returned products. Since the model is a mixed integer nonlinear programming and known as complex models, the Artificial Bee Colony (ABC) algorithm, simulation and complete search method are used to solve the problem. The results show that by increasing the purchase price of the returned products, the amount of returned products will increase. If the refurbishing cost of the returned products is high or the disposal cost is low, less inventory should be kept in the system with a high price of serviceable products. If the lost sale cost is high, the more inventory should be maintained. Moreover, by decreasing the price elasticity of demand, the customer’s demand increases, and then more inventory should be maintained in the system.
Problems of intellectual property accounting in industrial enterprises in Russia
Authors: Gorodilov Mikhail , Naam Marina , Murashova Yulia , Ketova Tatiana
Published: July 2021

This paper analyzes important accounting and financial problems associated with identification, determination of the moment of recognition, proper assessment of intellectual properties that are part of intangible assets, determination of their useful life, as well as the search for relevant methods of their depreciation. According to the generalization of theoretical and their own practical experience, the authors propose the approaches to solve these problems, designed to increase the level of reporting reliability for stakeholders, as well as to ensure proper accounting and control of these objects in order to provide their safety and rational use at industrial enterprises.
Innovative ideas of the intelligentsia in the field of management and zoning of the Urals territory
Authors: Selyaninova Gulsina
Published: July 2021

The article is devoted to the characteristics of changes in the management and administrative-territorial structure of the Urals under the regime of A.V. Kolchak (November 1918 -July 1919). These changes took place with the active participation and on the basis of the ideas of the intelligentsia involved in power in this period of Russian history. The administration and zoning of the Urals territories under A.V. Kolchak’s regime bore a succession character in relation to the previous regime of a “democratic counter-revolution” that existed during the reign of the Provisional Regional Government of the Urals (August -November 1918). However, the size of the subordinate territories under the Supreme Ruler was more ambitious, which also determined the need to solve more significant administrative tasks and changes in the area of zoning. The regions became large territorial units. They were divided into provinces, counties and volosts. S.S. Postnikov was the head of the Ural region, and the Perm province was ruled by Chistoserdov N.P. Administrators were appointed to rule the counties, who managed to hold a congress of the counties governors of the Perm province in February 1918.
Management of development of innovative ecosystems in reclamation
Authors: Yurchenko Irina , Bandurin Mikhail , Bandurina Inna
Published: July 2021

In the context of the coming digital globalization of the economy, an important factor in increasing the level of development of ameliorated agriculture is the widespread introduction of innovative agricultural technologies and agricultural production management into the practice of the domestic agro-industrial complex. The methodological basis of research is based on information and analytical methods, methods of expert assessments, system analysis and synthesis. Based on the results of the studies and the performed assessment, the role of innovation systems in the structure of the agricultural production economy and the experience of their application in the ameliorative sector of the economy in comparison with developed foreign countries are characterized. The influence of innovations on the efficiency and productivity of labor is shown and proposals are presented to reduce and eliminate the technological backwardness of agricultural production on reclaimed lands, consistent with the trends in the development of technologies for the production of advanced industries of the domestic and world economy. The main stages of the formation of production management systems, which provide support for the assignment of control actions, are presented. Reasons are revealed that hinder the full use of innovative technologies in agricultural production, associated with the lack of free funds among small-scale agricultural producers and their proper understanding of the strategic importance of innovations in the production process. A prognostic analysis of the innovative development of agricultural production based on “intelligent agricultural technologies”, is presented which unites objects via the Internet for receiving and exchanging information from built-in services.
Mechanisms of knowledge-driven innovation: evidence from Russia
Authors: Molodchik Mariia , Molodchik Anatoliy , Esaulova Irena
Published: July 2021

The paper aims to propose theoretical framework for knowledge-driven innovation and justify it empirically using database of 110 Russian companies. The study utilizes multidisciplinary approach and develops theoretical framework in the intersection of knowledge-based theory of a firm, the concept of learning organization, the concept of intellectual capital and the concept of self-development and self-organizational systems. The partial least square was applied for modelling the impact of the flexible structure, knowledge culture, transformational leadership on proactive employee behavior that in turn influences knowledge resources and organizational learning followed by company’s innovation. The study confirmed the key role of proactive behavior in knowledge-driven innovation. Findings revealed the highest impact of transformational leadership on employee behavior and innovation, as well as positive and significant impact of knowledge culture and indirect effect of flexible structure.
Innovative potential of enterprise from a differentiated approach standpoint based on the concept of innovations’ diffusion
Authors: Lazarev Vladimir , Churashkina Anna , Shulenkova Tatiana
Published: July 2021

The article contains the key results of the study of the essence of the innovative potential of an enterprise with solving the problems of strategic management of modern enterprises operating in the context of the innovation of the economy. As a vector for improving the theoretical and methodological foundations for solving problems in the innovation sphere, a differentiated approach to understanding the essence of the innovative potential of an enterprise is proposed. The possibility and expediency of differentiation based on types (strategies) of innovative behavior, identified based on the concept of diffusion of innovations, have been substantiated. The article reflects the main provisions of the author’s idea of the essence of the innovative potential of an enterprise within the framework of a given approach. The significance of the research results for solving theoretical, methodological, and applied problems is concretized.
Multilayered balanced indicators system for evaluating the results of innovation activities within the framework of cooperation
Authors: Kirillova Elena , Uvarova Nataly
Published: July 2021

A modified system of indicators for assessing the innovation activities effectiveness in the region based on data on patent and licensing activities in the framework of scientific and industrial cooperation is described. Also in the article we presented a general mechanism for innovation process effectiveness managing of such cooperative interaction. They are intended to be used as tools to support decision-making, allowing one to coordinate the cooperative indicators management. The proposed system of indicators provides transfer and decomposition of goals for planning operational activities by levels and actors of the innovation process in the cooperative formation, as well as monitoring their achievement. Taking into account the peculiarities of the innovation environment, the proposed balanced indicators system (hereinafter referred to as the BSC) focuses on non-financial logistics performance indicators and patent’s information. The structure of the BSC assumes a pyramid-layer structure, the number of elements of each layer is determined by the structural decomposition of the cooperative interaction corresponding level. The article describes stages of forming such BSC-maps process. As a tool for improving the balance of strategic maps for generating management decisions, a transition to “horizontal dynamics” is proposed, according to which at each level of logistics management, among all goals there is the greatest deviation from the target values, i.e., from the target values achieved to the least extent. These goals are the “target limitations” of the enterprise effective operation and they take greatest importance for further analysis of critical situations. For this purpose, a procedure for managing innovation environment by deviations is proposed.
Digitalization of communications with applicants as an innovative approach in modern higher education
Authors: Baranova Irina , Gapon Marina , Golova Elena
Published: July 2021

In modern complex conditions, characterized by an unstable situation caused by a global pandemic, the acceleration of digitalization processes in all spheres of life, innovative software products that help users to receive complete and up-to-date information on emerging issues are becoming more and more important. Usually even such fateful decisions as the choice of a future profession and educational institution are made on the basis of data collection in mobile applications. In this regard, research in the field of digitalization of communications between universities, applicants and other stakeholders at this stage of development of Russian educational services is quite important. This paper is devoted to the study of the issue of the establishment of mutually beneficial links between applicants and Russian universities. The authors propose the implementation of an organizational project in order to create a multifunctional mobile application “Applicant” aimed to provide target groups of users with versatile, up-to-date information about the state of university education market. The project describes in detail and justifies such points as the formation of a team, the functions and competencies of its members, the main stages and environment of implementation, the implementation schedule, product and educational results.
Сrowdfunding platforms as an example of innovation startup’s financial support
Authors: Akhmetova Julia
Published: July 2021

Financial support is very important in the innovative sphere, because it creates the basis of the whole economic development. There are several ways how this support can be organized: from the family money to government subsidy. This paper focused on a relatively new way how a startup as a small innovative business can gain finance - crowdfunding platforms. As a preparation for the analysis theoretical concepts of innovative startup investment were considered and the unique characteristics of crowdfunding market were examined. The purpose of the study is to underline main characteristic of startups as a way of financial innovation performance, analyze the determinants of crowdfunding platform’s effectiveness, define an optimal strategic behavior for a platform to accumulate greater amount of investment and increase the number of startups which achieve their financial goals. Analysis is based on the data from 105 crowdfunding platforms during last 3 year (from 2018 till 2020). As a result, based on the multiple linear regression an analysis was conducted which showed that age, platform type and scope are main characteristics of crowdfunding platform efficiency while commission type is not correlated with startup crowdfunding success rate.
Creative productivity of elderly scientists at different stages of professional development
Authors: Postavnev Vladimir M. , Postavneva Irina V. , Dvoinin Mikhail L. , Ginting Henndy
Published: July 2021

The article presents the results of research focusing on substantiation and development of the idea of preservation and multiplication of human capital. The issue of psychological prerequisites and social conditions for top achievements made by scientists is of scientific and practical relevance as well as identification of social and psychological factors encouraging the preservation of high productivity in elderly scientists over long periods of time. The objective of this research is to find the correlation between the key events in the academic biography and top achievements made by well-known elderly scientists at different stages of their professional development. The presented data were obtained with the help of the research interview “Life values and life journey” developed by V.S. Mukhina. The information contained in scientometric databases about the top achievements made by elderly scientists were analyzed and interpreted relying on the principles of differential acmeological analysis of professional activities conducted by famous scientists and their achievements made in the acme of their career. The correlation between the key events in the academic biographies of the interviewed elderly scientists and their top achievements has shown that reaching the acme is the result of psychological prerequisites (scientists’ personal qualities and the physical state) and social conditions of their professional activities (social status, belonging to a certain school of thought, access to organizational and financial resources). Over the whole time of academic activity conducted by senior scientists, there are usually a few productive periods called micro-acme in acmeology. It should be noted that top achievements made by scientists are typically spaced out and fall on the times with the best combination of prerequisites and conditions for scientific creativity. Within this research, identification of the most common combinations of prerequisites and conditions leading to top scientific achievements was beyond our focus. One of the promising research directions would be an attempt to identify the criteria for developing periodization of scientific productivity among elderly scientists.
Psychological determinants of manifestation of a person’s creativity at the stage of higher education
Authors: Grebneva Valentina Viktorovna , Korneeva Svetlana Anatolievna , Kuznetsova Lyudmila Borisovna , Miroshnikova Oksana Sergeevna , Moskalenko Svetlana Valeryevna
Published: July 2021

Despite the significance and effectiveness of numerous studies, the role and relationship of internal (psychological) and external (environmental) factors in the development of creativity at the stage of studying at a university are not clearly determined. The conducted study aims to analyze the psychological prerequisites for the development of a person’s creativity at student age. The study tests the hypothesis that students demonstrating a higher level of creativity have several individual psychological features including genetically predetermined ones. The deployed psychodiagnostic methods include the “creativity” scale of the Self-actualization diagnostic questionnaire “SAMOAL” (A.V. Lazukina, as adapted by N.F. Kalin), “Questionnaire for diagnostics of the dominating instinct” (V.I. Garbuzov); the Eysenck Personality Inventory (EPI), and “The method of diagnostics of the learning style parameters” (A. Soloman, R. Felder). The obtained results provide for a more precise description of the psychological portrait of a student with high creativity level as well as indicate the presence of genetically predetermined factors of predisposition to the development of creativity as a creative attitude towards life.
Pedagogical modeling of training teachers for working with gifted children
Authors: Fedotova E.L. , Nikitina E.A. , Seredkina A.S. , Garashchenko L.V. , Kazorina A.V.
Published: July 2021

The article deals with the issues of organizing the professional development of future teachers in basic general education and the system of additional education and the process of assisting gifted children and providing them with psychological and pedagogical support. The authors note that the quality of giftedness is most in-demand in modern society. At the same time, the question arises about the criteria and indicators of the formation of professional readiness to work with gifted children among student pedagogues. The analysis of publications on the training of future teachers makes it possible to discover that today there is a functioning system for identifying and supporting gifted children but not all specialists who ensure the implementation of the educational process in educational institutions are fully prepared to solve the assigned tasks that satisfy social and government needs. Therefore, the authors believe that one must carry out a set of measures that contribute to an efficient increase in the level of competence and professional skills of student pedagogues in the process of preparing future teachers for working with gifted children. The measures are based on a study of the experience of Russian and foreign specialists in the field of psychology and pedagogy that reflects the system of organizing education for young specialists at the university. The vector identified in the study in modeling the concept of professional training of students, and the certainty in the criteria and indicators that make up the readiness, the structural content of the development of readiness in future teachers, aimed at identifying and supporting gifted children. The authors identify broad prospects for the development of a new generation of professional training programs for student pedagogues, which are widely in demand in the context of the development of modern society.
Features of training pedagogues for supporting gifted children
Authors: Khodakova Nina Pavlovna , Antonova Anna Viktorovna , Semenova Tatiana , Chugainova Oksana
Published: July 2021

The prerequisites for the study: the informatization and digitalization of modern society have led to the development of informatization in education and digital pedagogy. However, the transformations that have taken place in the national education system have changed the attitude towards students who show outstanding abilities. This has led to the emergence of relevant regulatory documents as well as public funds, social programs, educational organizations, the main purpose of which is to identify, teach and develop gifted children. Nevertheless, in higher educational institutions, the issues of training teachers for psychological and pedagogical support of gifted children are considered narrowly, within the framework of certain disciplines and a single level of education. There is no training for teachers to work with parents of gifted children. The purpose of the study is to determine the features of training teachers for psychological and pedagogical support of gifted children and substantiate the necessary pedagogical conditions. Methods: the study of psychological and pedagogical literature, the analysis of the readiness of teachers for professional activity in the context of the digitalization of education and working to support gifted children in Moscow and the Moscow region, the analysis of the websites of educational organizations. The authors consider the problems of digitalization of education in the context of working with gifted children. The issues of using digital pedagogy, training pedagogical staff to use digital technologies in educational activities, and supporting gifted children are expounded. The authors determine the features of the content of further education courses for teachers and parents and the training of teachers for psychological and pedagogical support of gifted children. The possibility of using digital technologies and the system of additional education to train for supporting gifted children, their parents, and teachers is considered.
Stratégies d’orientations régulatrices et émotions : étude en gymnastique artistique
Authors: Patisson Jade , Debanne Thierry
Published: July 2021

L’objet de cette étude est de tester la TOR dans sa capacité à prédire les intensités émotionnelles de gymnastes à l’issue d’une compétition sportive. Un échantillon de gymnastes (n = 273 ; 239 femmes), de différents niveaux, a été confronté, de manière aléatoire, à deux contextes précompétitifs, l’un incitant à l’utilisation d’une stratégie régulatrice de prévention (Cpertes), l’autre à une stratégie régulatrice de promotion (Cgain). Pour chaque contexte, deux résultats de la compétition ont été présentés aux participants (SuccèsversusÉchec) de façon randomisée. Suite à la lecture des contextes, les participants ont complété l’échelle des stratégies d’OR, et après présentation de leur résultat, ils ont complété le questionnaire de fréquence émotionnelle. En accord avec les hypothèses, les ANOVAs mixtes à mesures répétées, ont révélé que (a) les scores de gaieté étaient significativement plus élevés en Cgainqu’en Cpertes, et (b) les scores de nervosité/agitation étaient significativement plus élevés en Cpertesqu’en Cgain. De manière particulièrement intéressante, l’étude a révélé des résultats opposés aux hypothèses, les scores de découragement étant significativement plus élevés en Cpertesqu’en Cgain, suggérant une spécificité du contexte de la compétition sportive sur les émotions.
Blasenkarzinom − Komplikationen der Harnableitung
Authors: Pfister David , Niegisch Günter
Published: July 2021

Auch heute noch stellt die radikale Zystektomie mit Anlage einer Harnableitung einen der komplikationsträchtigsten Eingriffe in der Uroonkologie dar. Insbesondere im Langzeitverlauf, aber auch perioperativ spielen dabei durch die Harnableitung bedingte Probleme eine wesentliche Rolle. Perioperativ stehen dabei im Wesentlichen gastrointestinale Probleme wie etwa ein Ileus, aber auch Infekte und frühe Komplikationen der unterschiedlichen Anastomosen im Vordergrund. Während ein Ileus ebenso wie perioperative Infekte i. d. R. medikamentös behandelt werden können, erfordern Insuffizienzen der intestinalen Anastomose regelhaft und Insuffizienzen der ureterointestinalen Anastomosen häufig operative Revisionen.

Im Langzeitverlauf können Narbenbildungen zu chronischen Harnabflussbehinderungen und bei kontinenten Harnableitungen zur Steinbildung führen und ebenso wie parastomale Hernien weitere Therapien erforderlich machen. Funktionelle Darmprobleme können die Lebensqualität der Patienten nachhaltig beeinflussen.

Durch eine verbesserte Vorbereitung präoperativ und die begleitenden Maßnahmen während des stationären Aufenthalts können nicht operationsbedingte Komplikationen signifikant reduziert werden.

Die Zystektomie mit der therapieassoziierten Morbidität ist ein Paradebeispiel für eine zentrumsbasierte Operation, um Komplikationen sowohl perioperativ als auch im weiteren Follow-up zu reduzieren.
Multiple Evanescent White Dot Syndrome (MEWDS) Associated with Progression of Lacquer Cracks in High Myopia
Authors: Ong Ariel Yuhan , Birtel Johannes , Charbel Issa Peter
Published: July 2021

Purpose To report a case of multiple evanescent white dot syndrome (MEWDS) associated with acute progression of lacquer cracks in high myopia.

Case Report A 41-year-old female patient with high myopia developed typical signs, symptoms, and disease course of MEWDS in her right eye. At the same time, the same eye showed progression of lacquer cracks when compared to images taken 2 months prior. Retinal imaging findings characteristic of MEWDS were most obvious on fundus autofluorescence, whereas alterations on color fundus photography, optical coherence tomography, fluorescein, and indocyanine green angiography were very mild, probably because of the myopia-related fundus pathology.

Conclusion We present a case of MEWDS co-occurring with acute progression of lacquer cracks. This adds to the increasing evidence that impaired integrity of the retinal pigment epithelium-Bruchʼs membrane complex may be a factor in causing MEWDS, possibly by exposing otherwise isolated antigens. The anatomy in a highly myopic eye may make it challenging to diagnose MEWDS-associated fundus changes.
Biomarker: der Weg zur individualisierten Therapie bei Nierenzelltumoren
Authors: Zeuschner Philip , Zaccagnino Angela , Junker Kerstin
Published: July 2021

In den letzten drei Jahrzehnten wurden Nierentumore, basierend auf histopathologischen und molekularen Merkmalen, immer umfassender differenziert. Dies hat inzwischen eine zunehmend größere Bedeutung für die klinische Praxis, da differenzierte Therapieoptionen sowohl für die organbegrenzten als auch für die metastasierten Nierenzelltumore zur Verfügung stehen. Die Kenntnis der molekularen Veränderungen ist Voraussetzung für die Entwicklung, aber auch für die differenzierte Anwendung zielgerichteter systemischer Therapieverfahren. Diese Arbeit gibt einerseits einen Überblick über die molekulare Differenzierung der Nierentumore, andererseits werden molekulare Biomarker zur Diagnose, Prognosebewertung und Therapieentscheidung vorgestellt und kritisch diskutiert.
Boron Lewis Pair Mediated C–H Activation and Borylation
Authors: Fontaine Frédéric-Georges , Desrosiers Vincent
Published: July 2021

In the few past years, the chemistry of frustrated Lewis pairs (FLP) has enabled a plethora of transformations that would otherwise only be possible using transition metal catalysts. Of particular interest are C–H bond activation and borylation reactions, which are the subject of this review. The FLP borylation chemistry is compared with the early borylation methodologies using strongly electrophilic borenium ions. We present the mechanism of the C–H borylation using inter- and intramolecular Lewis pairs, along with some applications of these transformations.

1 Introduction

2 Electrophilic Borylation

3 Intramolecular or Directed Electrophilic Borylation

4 Intermolecular FLP-Mediated C–H Borylation

5 Stoichiometric Borylation by Intramolecular FLPs

5.1 Csp–H Borylation

5.2 Csp2–H Borylation

5.3 Csp3–H Borylation

6 Catalytic Borylation by Intramolecular FLPs

7 Catalytic Borylation by Self-Assembled FLPs

8 Conclusion
Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides
Authors: Lin Song , Wood Devin P. , Guan Weiyang
Published: July 2021

Herein a bimetallic radical redox-relay strategy is employed to generate alkyl radicals under mild conditions with titanium(III) catalysis and terminated via hydrogen atom transfer with cobalt(II) catalysis to enact base-free isomerizations of N-Bz aziridines to N-Bz allylic amides. This reaction provides an alternative strategy for the synthesis of allylic amides from alkenes via a three-step sequence to accomplish a formal transpositional allylic amination.
Minimal Invasive Surgery for Gastroesophageal Reflux Disease and Hiatus Hernia—Our Experience: A Case Series with Review of Literature
Authors: Harvitkar Rafique Umer , Joshi Abhijit
Published: July 2021

Introduction Laparoscopic fundoplication (LF) has almost completely replaced the open procedure performed for gastroesophageal reflux disease (GERD) and hiatus hernia (HH). Several studies have suggested that long-term results with surgery for GERD are better than a medical line of management. In this retrospective study, we outline our experience with LF over 10 years. Also, we analyze the factors that would help us in better patient selection, thereby positively affecting the outcomes of surgery.

Patients and Methods In this retrospective study, we identified 27 patients (14 females and 13 males) operated upon by a single surgeon from 2010 to 2020 at our institution. Out of these, 25 patients (12 females and 13 males) had GERD with type I HH and 2 (both females) had type II HH without GERD. The age range was 24 to 75 years. All patients had undergone oesophago-gastro-duodenoscopy (OGD scopy). A total of 25 patients had various degrees of esophagitis. Two patients had no esophagitis. These patients were analyzed for age, sex, symptoms, preoperative evaluation, exact procedure performed (Nissen’s vs. Toupet’s vs. cruroplasty + gastropexy), morbidity/mortality, and functional outcomes. They were also reviewed to examine the length of stay, length of procedure, complications, and recurrent symptoms on follow-up. Symptoms were assessed objectively with a score for six classical GERD symptoms preoperatively and on follow-up at 1-, 4- and 6-weeks postsurgery. Further evaluation was performed after 6 months and then annually for 2 years.

Results 14 females (53%) and 13 males (48%) with a diagnosis of GERD (with type I HH) and type II HH were operated upon. The mean age was 46 years (24–75 years) and the mean body mass index (BMI) was 27 (18–32). The range of duration of the preoperative symptoms was 6 months to 2 years. The average operating time dropped from 130 minutes for the first 12 cases to 90 minutes for the last 15 cases. The mean hospital stay was 3 days (range: 2–4 days). In the immediate postoperative period, 72% (n = 18) of the patients reported improvement in the GERD symptoms, while 2 (8%) patients described heartburn (grade I, mild, daily) and 1 (4%) patient described bloating (grade I, daily). A total of 5 patients (20%) reported mild dysphagia to solids in the first 2 postoperative weeks. These symptoms settled down after 2 to 5 weeks of postoperative proton-pump inhibitor (PPI) therapy and by adjusting consistency of oral feeds. There was no conversion to open, and we observed no perioperative mortality. There were no patients who underwent redo surgeries in the series.

Conclusion LF is a safe and highly effective procedure for a patient with symptoms of GERD, and it gives long-term relief from the symptoms. Stringent selection criteria are necessary to optimize the results of surgery. Experience is associated with a significant reduction of operating time.
Artificial Intelligence in Hepatology: A Narrative Review
Authors: Vaz Karl , Goodwin Thomas , Kemp William , Roberts Stuart , Majeed Ammar
Published: July 2021

There has been a tremendous growth in data collection in hepatology over the last decade. This wealth of “big data” lends itself to the application of artificial intelligence in the development of predictive and diagnostic models with potentially greater accuracy than standard biostatistics. As processing power of computing systems has improved and data are made more accessible through the large databases and electronic health record, these more contemporary techniques for analyzing and interpreting data have garnered much interest in the field of medicine. This review highlights the current evidence base for the use of artificial intelligence in hepatology, focusing particularly on the areas of diagnosis and prognosis of advanced chronic liver disease and hepatic neoplasia.
Neonatal Gastric Perforation: 14-Year Experience from a Tertiary Neonatal Intensive Care Unit
Authors: Sakaria Rishika P. , Zaveri Parul G.
Published: July 2021

Objective Neonatal gastric perforations (NGPs) are rare and account for 7 to 12% of all gastrointestinal perforations in the neonatal period. The etiology and prognostic factors associated with NGP remain unclear. The aim of this study is to review the cases of NGP in our neonatal intensive care unit (NICU) in the past 14 years and describe the risk factors, clinical presentation, and outcomes associated with it.

Study Design A retrospective chart review of neonates with gastric perforation admitted to the NICU between June 2006 and December 2020 was performed. Data regarding their antenatal and neonatal characteristics, laboratory and radiological results, intra-operative findings, hospital course, and outcomes were recorded.

Results We identified 350 patients with gastrointestinal perforation at our center during the study period of which 14 (4%; nine males and five females) patients were diagnosed with NGP during surgery. A total of 71% neonates were born preterm (range: 24–39 weeks, median: 34 weeks). Two neonates (14%) were SGA. Only one neonate received cardiopulmonary resuscitation at birth. In all neonates, except two, perforation occurred within the first 10 days of life (median: 4 days, range: 1–22 days). In total, 79% infants received feeds prior to perforation. Ten neonates had a feeding tube, and one neonate had a gastrostomy tube placed prior to perforation. Abdominal distension and pneumoperitoneum were present in all neonates. Majority of the babies had metabolic acidosis (64%) and elevated C-reactive protein (79%). Most (86%) neonates received surgical intervention within 12 hours. Overall survival in our study was 93%.

Conclusion NGP is a rare entity seen mostly in preterm infants within the first 10 days of life. Clinical presentation is similar to perforation anywhere along the gastrointestinal tract and definite diagnosis requires exploratory laparotomy. With prompt recognition and surgical intervention, the overall mortality related to neonatal gastric perforation is low.

Key Points
Effect of Incorporation of Different Concentrations of Silver Nanoparticles as an Antimicrobial Agent on the Flexural and Impact Strength of Heat-Cured Denture Base Resin
Authors: Sarkar Piyali , Garg Sandeep , Kalra Nidhi Mangtani
Published: July 2021

Aim This article evaluates the effect of incorporating different concentrations of silver nanoparticles as an antimicrobial agent on the flexural and impact strength of heat-cured denture base resin.

Material and Methods A total of 80 specimens of polymethyl methacrylate resin were fabricated (40 for flexural strength and 40 for impact strength). Specimens were fabricated using stainless steel die of dimension 65 mm × 10 mm × 2.5 mm as per the American Dental Association specification no. 12, and 50 mm × 6 mm × 4 mm as per ISO 1567:1999 for flexural strength and impact strength, respectively, and were divided into four groups (A, B, C, and D) based on the concentrations of silver nanoparticles (0%, 2.5%, 5%, and 10%). The specimens were subjected to three-point bending test and Izod impact tester for testing flexural and impact strength, respectively. Data obtained was compiled and analyzed using one-way analysis of variance and post hoc tests.

Results Results showed that for both the properties, maximum strength was observed in group A (control) followed by groups B and C, and minimum was observed in group D. A statistically significant difference in flexural strength was found among all the groups, whereas no statistically significant difference in impact strength was found among any of the groups.

Conclusion Within the limitations of this in vitro study, it was concluded that though incorporation of silver nanoparticles exhibited no effect on the impact strength of heat cure denture base resin, it decreased the flexural strength, so it should be used cautiously.