bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Evaluation Method of the Health-Related Physical Environment in Urbanizing Areas: A Case Study From a University Campus in China
Authors: Wu Yizhou , Wu Siqin , Qiu Xiaoli , Wang Shuai , Yao Shenyi , Li Wentao , You Heyuan , Zhang Jinrong , Xia Shuyi , Guo Yufei
Published: February 2022

Environmental deterioration in urbanizing areas increases the risks of sudden death as well as chronic, infectious, and psychological diseases. Quantifying health-related physical environment can assess the health risk of urban residents. This study uses an integrated evaluation method to simulate the health-related physical environment in the four dimensions of acoustic, wind, thermal, and landscape. According to the case study of one university campus in an urbanizing area in China, results show that (1) areas with unqualified equivalent A sound levels are generally the sports area, green square 1 and laboratory areas, and residents who stay in these areas for a long time suffer the risks of hearing loss and mental stress. (2) The windless area ratio of teaching area 1 and dormitory area 4 is larger than 20%, and respiratory health risks increase because these areas relate to relatively wind discomfort. (3) The high-temperature zone ratio of sports area and green square 2 is larger than 50%, and heatstroke risks increase since these areas relate with low thermal comfort. (4) The overall landscape perception level of dormitories and dining areas is lower than that of the teaching area, and it can cause anxiety and irritability. (5) The sports area has the lowest average overall score of the health-related physical environment among all functional areas, followed by laboratory areas. These findings indicate that the proposed model and method can be valuable tools for the pre-evaluation and optimization of urban planning. It can reduce the health risks of residents in urbanizing areas and can benefit residents' health and urban sustainable development.
How Do Dark Streams of Arctic Glacial Meltwater Affect Plankton?
Authors: Szeligowska Marlena , Benkort Déborah , Trudnowska Emilia , Błachowiak-Samołyk Katarzyna
Published: February 2022

In the last decades, the temperatures of Earth’s atmosphere and its oceans have increased significantly. Warming strongly affects the Arctic, where we can observe fast glacial melt during the summer. Meltwater brings debris from the land into the coastal ocean, creating zones with brown water. This seawater darkening can affect the living conditions of marine organisms and possibly threaten marine life in the future. To address this issue, we studied the particles that make the seawater dark and the effect that seawater darkening has on the tiny plants and animals in the coastal waters of the European Arctic. Open, clear waters were greenish and full of life, while in muddy brown zones, we observed intensive “snowstorms” of particles. Our study taught us about how marine organisms interact with these particles. Based on our observations, we can design computer models to help us predict the fate of the coastal waters in a future, warmer Arctic.
The Effect of Intraoperative Transversus Abdominis Plane Blocking on Postoperative Pain After Laparoscopic Transabdominal Pre-peritoneal (TAPP) Groin Hernia Repair
Authors: Chamzin Alexandros , Frountzas Maximos , Gkiokas George , Kouskouni Evaggelia , Xanthos Theodoros , Michalopoulos Nikolaos V.
Published: February 2022

Background

Managing postoperative pain even after laparoscopic groin hernia repair still remains an interesting challenge for clinicians especially for patients of high risk. Plenty of operative techniques and analgesic methods have been proposed in order to minimize postoperative pain after laparoscopic groin hernia repair. The aim of the present study is to compare transverse abdominis plane (TAP)-block with local analgesic infiltration at trocar entry sites in the terms of reducing postoperative pain.

Methods

Patients that underwent laparoscopic trans-abdominal pre-peritoneal (TAPP) groin hernia repair in a high-volume university hospital were included. Patients were divided in two groups depending on the analgesic method used. Pain was assessed using Visual Numerical Scale (VNS) score.

Results

Thirty patients were included. Intraoperative TAP-block seemed to be superior in terms of decreasing pain at the hernia area and at the trocar insertion site (p < 0.05) compared to local analgesic infiltration at the trocar insertion site at 6, 12 and 24 h after surgery (p < 0.05). In addition, pain reduction was more effective in rest rather than in motion for both analgesic methods.

Conclusion

Intraoperative TAP-block under direct vision seems to be an effective, fast and easy technique in order to reduce postoperative pain after laparoscopic groin hernia repair, but more studies are required to validate these results in a prospective and randomized context.
Quorum Sensing Controls the CRISPR and Type VI Secretion Systems in Aliivibrio wodanis 06/09/139
Authors: Maharajan Amudha Deepalakshmi , Hjerde Erik , Hansen Hilde , Willassen Nils Peder
Published: February 2022

For bacteria to thrive in an environment with competitors, phages and environmental cues, they use different strategies, including Type VI Secretion Systems (T6SSs) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) to compete for space. Bacteria often use quorum sensing (QS), to coordinate their behavior as the cell density increases. Like other aliivibrios, Aliivibrio wodanis 06/09/139 harbors two QS systems, the main LuxS/LuxPQ system and an N-acyl homoserine lactone (AHL)-mediated AinS/AinR system and a master QS regulator, LitR. To explore the QS and survival strategies, we performed genome analysis and gene expression profiling on A. wodanis and two QS mutants (ΔainS and ΔlitR) at two cell densities (OD600 2.0 and 6.0) and temperatures (6 and 12°C). Genome analysis of A. wodanis revealed two CRISPR systems, one without a cas loci (CRISPR system 1) and a type I-F CRISPR system (CRISPR system 2). Our analysis also identified three main T6SS clusters (T6SS1, T6SS2, and T6SS3) and four auxiliary clusters, as well about 80 potential Type VI secretion effectors (T6SEs). When comparing the wildtype transcriptome data at different cell densities and temperatures, 13–18% of the genes were differentially expressed. The CRISPR system 2 was cell density and temperature-independent, whereas the CRISPR system 1 was temperature-dependent and cell density-independent. The primary and auxiliary clusters of T6SSs were both cell density and temperature-dependent. In the ΔlitR and ΔainS mutants, several CRISPR and T6SS related genes were differentially expressed. Deletion of litR resulted in decreased expression of CRISPR system 1 and increased expression of CRISPR system 2. The T6SS1 and T6SS2 gene clusters were less expressed while the T6SS3 cluster was highly expressed in ΔlitR. Moreover, in ΔlitR, the hcp1 gene was strongly activated at 6°C compared to 12°C. AinS positively affected the csy genes in the CRISPR system 2 but did not affect the CRISPR arrays. Although AinS did not significantly affect the expression of T6SSs, the hallmark genes of T6SS (hcp and vgrG) were AinS-dependent. The work demonstrates that T6SSs and CRISPR systems in A. wodanis are QS dependent and may play an essential role in survival in its natural environment.
Three-Dimensional Wheat Modelling Based on Leaf Morphological Features and Mesh Deformation
Authors: Zheng Chenxi , Wen Weiliang , Lu Xianju , Chang Wushuai , Chen Bo , Wu Qiang , Xiang Zhiwei , Guo Xinyu , Zhao Chunjiang
Published: February 2022

The three-dimensional (3D) morphological structure of wheat directly reflects the interrelationship among genetics, environments, and cropping systems. However, the morphological complexity of wheat limits its rapid and accurate 3D modelling. We have developed a 3D wheat modelling method that is based on the progression from skeletons to mesh models. Firstly, we identified five morphological parameters that describe the 3D leaf features of wheat from amounts of 3D leaf digitizing data at the grain filling stage. The template samples were selected based on the similarity between the input leaf skeleton and leaf templates in the constructed wheat leaf database. The leaf modelling was then performed using the as-rigid-as-possible (ARAP) mesh deformation method. We found that 3D wheat modelling at the individual leaf level, leaf group, and individual plant scales can be achieved. Compared with directly acquiring 3D digitizing data for 3D modelling, it saves 79.9% of the time. The minimum correlation R2 of the extracted morphological leaf parameters between using the measured data and 3D model by this method was 0.91 and the maximum RMSE was 0.03, implying that this method preserves the morphological leaf features. The proposed method provides a strong foundation for further morphological phenotype extraction, functional–structural analysis, and virtual reality applications in wheat plants. Overall, we provide a new 3D modelling method for complex plants.
Growing Neural Gas with Different Topologies for 3D Space Perception
Authors: Toda Yuichiro , Wada Akimasa , Miyase Hikari , Ozasa Koki , Matsuno Takayuki , Minami Mamoru
Published: February 2022

Three-dimensional space perception is one of the most important capabilities for an autonomous mobile robot in order to operate a task in an unknown environment adaptively since the autonomous robot needs to detect the target object and estimate the 3D pose of the target object for performing given tasks efficiently. After the 3D point cloud is measured by an RGB-D camera, the autonomous robot needs to reconstruct a structure from the 3D point cloud with color information according to the given tasks since the point cloud is unstructured data. For reconstructing the unstructured point cloud, growing neural gas (GNG) based methods have been utilized in many research studies since GNG can learn the data distribution of the point cloud appropriately. However, the conventional GNG based methods have unsolved problems about the scalability and multi-viewpoint clustering. In this paper, therefore, we propose growing neural gas with different topologies (GNG-DT) as a new topological structure learning method for solving the problems. GNG-DT has multiple topologies of each property, while the conventional GNG method has a single topology of the input vector. In addition, the distance measurement in the winner node selection uses only the position information for preserving the environmental space of the point cloud. Next, we show several experimental results of the proposed method using simulation and RGB-D datasets measured by Kinect. In these experiments, we verified that our proposed method almost outperforms the other methods from the viewpoint of the quantization and clustering errors. Finally, we summarize our proposed method and discuss the future direction on this research.
Optimal Design of an Inverter-Fed PMSM for a Brake System Considering Variation in Motor Control Parameters and Input Voltage
Authors: Hwang Kyu-Yun , Yoon Keun-Young
Published: February 2022

This study proposes an optimal design approach for an inverter-fed permanent magnet synchronous motor (PMSM) considering the variation in motor control parameters and input voltage (inverter output voltage), which vary with respect to the temperature and loading conditions, in an integrated brake system. In an integrated brake system, a quick response to load changes is crucial. Therefore, in this study, to consider the fluctuation in control variables and input voltage, the motor control parameters and input voltage were first calculated according to the operating temperature and loading condition. Subsequently, based on the calculated conditions and the approximated motor input voltage and control parameters, the objective functions corresponding to motor characteristics in transient and steady states were formulated using design-of-experiment (DOE), the moving least square method (MLSM), and the finite element method (FEM). Finally, the optimal design was performed using the genetic algorithm (GA). The validity of the proposed optimal design approach was verified by comparing its optimization results with the FEM analysis results. Thus, it was confirmed that a motor can be designed for an integrated brake system by considering the motor control parameters and motor input voltage, which vary with the driving conditions.
Comprehensive Characterization and Quantification of Antioxidant Compounds in Finger Lime (Citrus australasica L.) by HPLC-QTof-MS and UPLC-MS/MS
Authors: Aznar Ramón , Rodríguez-Pérez Celia , Rai Dilip K.
Published: February 2022

Australian finger limes (Citrus australasica L.), an unusual citrus due to its unique pulp with a caviar-like appearance, has reached the global market as a promising source of bioactive compounds that promote health. This research was, therefore, performed to shed light on the bioactivity and composition of different parts of Citrus australasica L. (peel and pulp). Initial ultrasound-assisted extraction using MeOH:H2O (80:20, v/v) was carried out. After that, four fractions (hexane, ethyl acetate, butanol and water) were generated through liquid–liquid partitioning, and the total phenolic content (TPC) and antioxidant activity were evaluated using the Folin–Ciocalteu and the ferric reducing antioxidant power (FRAP) assays, respectively. The ethyl acetate fraction in the peel, which presented the highest values of TPC and antioxidant activity, was characterized using high-performance liquid chromatography coupled to quadrupole time-of-flight (HPLC-QTof) mass spectrometry. Fifteen compounds were identified, of which seven were characterized for the first time in this matrix. Moreover, ten phenolic compounds were quantified using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS). The major compounds in the sample were citric acid, pyrogallol, caffeic acid, coumarin, rutin, naringin, 2-coumaric acid, didymin, naringenin and isorhamnetin, which were found in a range from 2.7 to 8106.7 µg/g sample dry weight. Finally, the results presented in this novel work confirmed that the peel by-product of C. australasica L. is a potential source of bioactive compounds and could result in a positive outcome for the food, cosmetics and pharmaceutical industries.
Spatiotemporal Characteristics of Droughts and Their Propagation during the Past 67 Years in Northern Thailand
Authors: Zhao Baoxu , Yang Dawen , Yang Shuyu , Santisirisomboon Jerasorn
Published: February 2022

Droughts grow concurrently in space and time; however, their spatiotemporal propagation is still not fully studied. In this study, drought propagation and spatiotemporal characteristics were studied in northern, northeastern, and central Thailand (NNCT). The NNCT is an important agricultural exporter worldwide, and droughts here can lead to considerable pressure on the food supply. This study investigated meteorological drought and soil drought in northern Thailand and identified 70 meteorological drought events and 44 soil drought events over 1948–2014. Severe droughts (droughts with long trivariate return periods) mainly occurred after 1975 and were centered in northern and northeastern Thailand. Meteorological drought and soil drought that occurred during 1979–1980 had the longest trivariate return periods of 157 years and 179 years, respectively. The drought centers were mainly located in the Chao Phraya River basin and the Mun River basin. The mean propagation ratios of all drought parameters (duration, area, severity) were lower than 1, indicating that the underlying surface can serve as a buffer to alleviate water deficits. Most of the probability distribution coefficients and all drought propagation ratios of the three drought parameters were found to change significantly based on a moving-window method, indicating that the drought parameters and propagation from meteorological drought to soil drought were non-stationary. Significant increasing trends were detected in mean values of most drought parameters, ranging from 2.4%/decade to 16.6%/decade. Significant decreasing trends were detected in coefficients of skewness (Cs) of all drought parameters and coefficients of variation (Cv) of most drought parameters, ranging from −3.3 to −12.4%/decade, and from −5.5 to −19.4%/decade, respectively. The propagation ratios of all drought parameters showed significant increasing trends, indicating that the function of the underlying surface as a buffer has become weaker. The drought propagation ratios were found to be positively related to two climate indices, the phase index (PI) and the climate seasonality index (CSI). These findings will help to develop a better understanding and management of water resources in Thailand.
Study on the Mechanism of Haze Pollution Affected by Urban Population Agglomeration
Authors: Li Xuesong , Zhou Min , Zhang Wenyu , Yu Kewei , Meng Xin
Published: February 2022

Population agglomeration and haze pollution are two major problems that urban development will inevitably face in the future. Population agglomeration has a spatial impact on smog pollution through scale and intensive effects. This paper uses panel data from 236 prefecture-level cities in China from 2001 to 2012 to verify the impact of urban population agglomeration on haze pollution and its mechanism based on a spatial lag model. The research shows that: (1) China’s urban haze pollution has a significant positive spatial spillover effect, and presents a spatial distribution state of high-high and low-low agglomeration. (2) There is a significant “N-type” nonlinear relationship between urban population agglomeration and haze pollution. (3) At present, the scale effect of urban population agglomeration in China is greater than the intensification effect, and the scale effect as well as intensification effect have opposite effects on haze pollution. This shows that urban layout should be scientifically planned, urban population should be reasonably controlled, production efficiency should be improved, and green development should be promoted to deal with haze pollution. (4) The spillover effect of urban population agglomeration on haze pollution is significantly greater than the direct effect, indicating that local haze pollution is more likely to be affected by spatially related regions, indicating that strengthening regional coordination and cooperation and joint prevention and control are necessary to control haze pollution.
Identification and Validation of an Annexin-Related Prognostic Signature and Therapeutic Targets for Bladder Cancer: Integrative Analysis
Authors: Yao Xitong , Qi Xinlei , Wang Yao , Zhang Baokun , He Tianshuai , Yan Taoning , Zhang Lu , Wang Yange , Zheng Hong , Zhang Guosen , Guo Xiangqian
Published: February 2022

Abnormal expression and dysfunction of Annexins (ANXA1-11, 13) have been widely found in several types of cancer. However, the expression pattern and prognostic value of Annexins in bladder cancer (BC) are currently still unknown. In this study, survival analysis by our in-house OSblca web server revealed that high ANXA1/2/3/5/6 expression was significantly associated with poor overall survival (OS) in BC patients, while higher ANXA11 was associated with increased OS. Through Oncomine and GEPIA2 database analysis, we found that ANXA2/3/4/13 were up-regulated, whereas ANXA1/5/6 were down-regulated in BC compared with normal bladder tissues. Further LASSO analysis built an Annexin-Related Prognostic Signature (ARPS, including four members ANXA1/5/6/10) in the TCGA BC cohort and validated it in three independent GEO BC cohorts (GSE31684, GSE32548, GSE48075). Multivariate COX analysis demonstrated that ARPS is an independent prognostic signature for BC. Moreover, GSEA results showed that immune-related pathways, such as epithelial–mesenchymal transition and IL6/JAK/STAT3 signaling were enriched in the high ARPS risk groups, while the low ARPS risk group mainly regulated metabolism-related processes, such as adipogenesis and bile acid metabolism. In conclusion, our study comprehensively analyzed the mRNA expression and prognosis of Annexin family members in BC, constructed an Annexin-related prognostic signature using LASSO and COX regression, and validated it in four independent BC cohorts, which might help to improve clinical outcomes of BC patients, offer insights into the underlying molecular mechanisms of BC development and suggest potential therapeutic targets for BC.
Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights
Authors: Uprety Bhawna , Abrahamse Heidi
Published: February 2022

Despite some significant advancements, breast cancer has become the most prevalent cancer in the world. One of the main reasons for failure in treatment and metastasis has been attributed to the presence of cancer initiating cells—cancer stem cells. Consequently, research is now being focussed on targeting cancer cells along with their stem cell population. Non-oncology drugs are gaining increasing attention for their potent anticancer activities. Metformin, a drug commonly used to treat type 2 diabetes, is the best example in this regard. It exerts its therapeutic action by activating 5′ adenosine monophosphate-activated protein kinase (AMPK). Activated AMPK subsequently phosphorylates and targets several cellular pathways involved in cell growth and proliferation and the maintenance of stem-like properties of cancer stem cells. Therefore, AMPK is emerging as a target of choice for developing effective anticancer drugs. Vanadium compounds are well-known PTP inhibitors and AMPK activators. They find extensive applications in treatment of diabetes and obesity via PTP1B inhibition and AMPK-mediated inhibition of adipogenesis. However, their role in targeting cancer stem cells has not been explored yet. This review is an attempt to establish the applications of insulin mimetic vanadium compounds for the treatment of breast cancer by AMPK activation and PTP1B inhibition pathways.
A Comparative Study on the Anti-Corrosive Performance of Zinc Phosphate in Powder Coatings
Authors: Yang Shuai (Marshall) , Huang Jinbao , Chen Jian , Noël James Joseph , Barker Ivan , Henderson Jeffrey Daniel , He Ping , Zhang Haiping , Zhang Hui , Zhu Jesse
Published: February 2022

Powder coatings are gaining popularity for their economic and environmental benefits. Additives (pigments) such as zinc phosphate enhance the anti-corrosive properties of coatings, but their behavior in powder coatings has not been extensively studied. In this study, zinc phosphate was incorporated into three powder coating systems: polyester clearcoat, polyester and epoxy coatings with filler BaSO4. Neutral salt spray and electrochemical tests (OCP, LPR, and EIS) confirmed that the anti-corrosive performance improved with the addition of zinc phosphate. The optimal additive dosage was determined to be 2% for all of the coating systems studied here, based on salt spray tests. Here, the time until failure increased by 1.5 to 2 times. Using electrochemical tests, an optimal additive dosage of 8% was found for the polyester clearcoat, while the other coating systems maintained an optimal additive dosage of 2%. Performance increased by as much as one order of magnitude based on resistance/impedance measurements. This suggested a synergistic effect between the additive and the filler. The passivation layer was confirmed by both X-ray diffraction and Raman spectroscopy. Based on the results and discussion presented in this article, the discrepancy was caused by different features of the two tests, such that the electrochemical tests probe the function of intact coatings, whereas salt spray measures only the corrosion spreading from the scribe. It is proposed that the two test methods characterize different aspects of the coatings, corresponding to their service conditions. This has theoretical and practical significance in the evaluation of anti-corrosive coatings. Other properties of the coatings, including adhesion, gloss, distinctness-of-image, and pencil hardness, were measured as per applicable standards and the conformance was verified.
An Incomplete European Barcode Library Has a Strong Impact on the Identification Success of Lepidoptera from Greece
Authors: Huemer Peter , Mutanen Marko
Published: February 2022

Species identification by means of DNA barcodes depends essentially on the scope and quality of a relevant reference library. The first analysis of a large number (about 600 morphospecies) of southern European Lepidoptera (Greece: Peloponnese) shows both the advantages and disadvantages with regard to a reliable identification of Mediterranean species. We determined 946 DNA barcode sequences from 47 families, of which 929 sequences from 46 families were successfully assigned to a Barcode Index Number (BIN) in the global Barcode of Life Data Systems (BOLD) database. A species level identification for 485 BINs representing 477 Linnaean names was successful. These taxa include 34 new records for Greece. However, 128 BINs (c. 20% of the inventory) could not be attached to a Linnaean name from referenced sequences available in BOLD. Of these BINs, 99 are new and hence represent unique records for BOLD. Intra- and inter-BIN divergences are presented and discussed. An initial and preliminary in-depth analysis of randomly selected species indicates an incomplete DNA barcode library in terms of Linnean taxa, in addition to a considerable number of probably undescribed species. It is therefore strongly recommended that the already advanced European barcode library of Lepidoptera should be supplemented with not-yet-sequenced taxa from the Mediterranean.
Half Friend, Half Enemy? Comparative Phytophagy between Two Dicyphini Species (Hemiptera: Miridae)
Authors: Souto Paula , Abraços-Duarte Gonçalo , da Silva Elsa Borges , Figueiredo Elisabete
Published: February 2022

Despite their importance as biological control agents, zoophytophagous dicyphine mirids can produce economically important damage. We evaluated the phytophagy and potential impact on tomato plants of Dicyphus cerastii and Nesidiocoris tenuis. We developed a study in three parts: (i) a semi-field trial to characterize the type of plant damage produced by these species on caged tomato plants; (ii) a laboratory experiment to assess the effect of fruit ripeness, mirid age, and prey availability on feeding injuries on fruit; and (iii) a laboratory assay to compare the position of both species on either fruit or plants, over time. Both species produced plant damage, however, although both species produced scar punctures on leaves and necrotic patches on petioles, only N. tenuis produced necrotic rings. Both species caused flower abortion at a similar level. Overall, N. tenuis females produced more damage to tomato fruit than D. cerastii. There was an increased frequency of D. cerastii females found on the plants over time, which did not happen with N. tenuis. Our results suggested that, although D. cerastii caused less damage to fruit than N. tenuis, it still fed on them and could cause floral abortion, which requires field evaluation and caution in its use in biological control strategies.
Usefulness of the C2HEST Score in Predicting the Clinical Outcomes of COVID-19 in Diabetic and Non-Diabetic Cohorts
Authors: Gajecki Damian , Doroszko Adrian , Trocha Małgorzata , Giniewicz Katarzyna , Kujawa Krzysztof , Skarupski Marek , Gawryś Jakub , Matys Tomasz , Szahidewicz-Krupska Ewa , Rola Piotr , Stachowska Barbara , Halupczok-Żyła Jowita , Adamik Barbara , Kaliszewski Krzysztof , Kilis-Pstrusinska Katarzyna , Letachowicz Krzysztof , Matera-Witkiewicz Agnieszka , Pomorski Michał , Protasiewicz Marcin , Madziarski Marcin , Konikowska Klaudia , Remiorz Agata , Orłowska Maja , Proc Krzysztof , Szymala-Pedzik Małgorzata , Zorawska Joanna , Lindner Karolina , Sokołowski Janusz , Jankowska Ewa A. , Madziarska Katarzyna
Published: February 2022

Background: Diabetes mellitus is among the most frequent comorbidities worsening COVID-19 outcome. Nevertheless, there are no data regarding the optimal risk stratification of patients with diabetes and COVID-19. Since individual C2HEST components reflect the comorbidities, we assumed that the score could predict COVID-19 outcomes. Material and Methods: A total of 2184 medical records of patients hospitalized for COVID-19 at the medical university center were analyzed, including 473 diabetic patients and 1666 patients without any glucose or metabolic abnormalities. The variables of patients’ baseline characteristics were retrieved to calculate the C2HEST score and subsequently the diabetic and non-diabetic subjects were assigned to the following categories: low-, medium- or high-risk. The measured outcomes included: in-hospital mortality; 3-month and 6-month all-cause mortality; non-fatal end of hospitalization (discharged home/sudden-deterioration/rehabilitation) and adverse in-hospital clinical events. Results: A total of 194 deaths (41%) were reported in the diabetic cohort, including 115 in-hospital deaths (24.3%). The 3-month and 6-month in-hospital mortality was highest in the high-risk C2HEST stratum. The C2HEST score revealed to be more sensitive in non-diabetic-group. The estimated six-month survival probability for high-risk subjects reached 0.4 in both cohorts whereas for the low-risk group, the six-month survival probability was 0.7 in the diabetic vs. 0.85 in the non-diabetic group—levels which were maintained during whole observation period. In both cohorts, receiver operating characteristics revealed that C2HEST predicts the following: cardiogenic shock; acute heart failure; myocardial injury; and in-hospital acute kidney injury. Conclusions: We demonstrated the usefulness and performance of the C2HEST score in predicting the adverse COVID-19 outcomes in hospitalized diabetic subjects.
The Influence of the Locus of Control Construct on the Efficacy of Physiotherapy Treatments in Patients with Chronic Pain: A Systematic Review
Authors: Álvarez-Rodríguez Julia , Leirós-Rodríguez Raquel , Morera-Balaguer Jaume , Marqués-Sánchez Pilar , Rodríguez-Nogueira Óscar
Published: February 2022

The biopsychosocial paradigm contemplates the patient’s personality traits in physiotherapy treatments for chronic pain. Among these traits, the locus of control has a direct relationship with the person’s coping strategies in the face of their health problems. The objective of this systematic review was to assess the influence of locus of control on the efficacy of physiotherapy treatments in patients with chronic pain. A systematic review of the publications of the last ten years in Pubmed, Scopus, Science Direct and Web of Science databases was conducting with the terms physical therapy modalities, chronic pain, internal-external control, self-management, physical therapy and physiotherapy. The inclusion criteria were participants with chronic pain lasting at least three months who have received at least one session of physical therapy; the studies should have collected the patient’s locus of control as a prognostic factor at the beginning of physiotherapy treatment; the variables studied should include the pain intensity or clinical variables related to pain. A total of 13 articles were found, of which three were experimental studies and ten were observational studies. The included samples had chronic knee pain, nonspecific back pain, low back pain or neck pain; were people over 65 years of age or patients who had undergone hand surgery. In patients with chronic pain for more than three months, the locus of control construct participates as a predictor of the results of physiotherapy treatment. The presence of an internal locus of control favors better results. The personality traits of the subjects represent an important factor to take into account when planning physiotherapy treatments.
Enhancement of Biofunctionalization by Loading Manuka Oil on TiO2 Nanotubes
Authors: Kim Seo-Young , Kim Yu-Kyoung , Jang Yong-Seok , Lee Min-Ho
Published: February 2022

Metallic implants (mesh) for guided bone regeneration can result in foreign body reactions with surrounding tissues, infection, and inflammatory reactions caused by micro-organisms in the oral cavity after implantation. This study aimed to reduce the possibility of surgical failure caused by microbial infection by loading antibacterial manuka oil in a biocompatible nanostructure surface on Ti and to induce stable bone regeneration in the bone defect. The manuka oil from New Zealand consisted of a rich β-triketone chemotype, leptospermone, which showed strong inhibitory effects against several bacteria, even at very low oil concentrations. The TiO2 nanotubular layer formed by anodization effectively enhanced the surface hydrophilicity, bioactivity, and fast initial bone regeneration. A concentration of manuka oil in the range of 0.02% to less than 1% can have a synergistic effect on antibacterial activity and excellent biocompatibility. A manuka oil coating (especially with a concentration of 0.5%) on the TiO2 nanotube layer can be expected not only to prevent stenosis of the connective tissue around the mesh and inflammation by microbial infection but also to be effective in stable and rapid bone regeneration.
Investigation of SERS and Electron Transport Properties of Oligomer Phenylacetyne-3 Trapped in Gold Junctions
Authors: Liu Ziyu , Hu Tingting , Adam Balila Muwafag Osman , Zhang Jihui , Zhang Yujin , Hu Wei
Published: February 2022

Molecular junctions hold great potential for future microelectronics and attract people’s attention. Here, we used density functional theory calculations (DFT) to investigate the surface-enhanced Raman spectroscopy (SERS) and electron transport properties of fully π-conjugated oligomers (phenylacetylene)-3 (OPE-3) trapped in gold junctions. The effects of charge injection, an applied electric field, and molecular deformation are considered. We found that a new Raman peak located at around 1400 cm−1 appears after the injection of a charge, which agrees well with the experiment. The external electric field and configurational deformation hardly affect the Raman spectra, indicating that the electronic rather than the geometrical structure determines the Raman response. Nonequilibrium Green’s function (NEGF) calculations show that both the rotation of the benzene groups and an increased electrode distance largely reduced the conductivity of the studied molecular junctions. The present investigations provide valuable information on the effect of charging, electric field, and deformation on the SERS and conductivity of molecular junctions, helping the development of molecular devices.
Isolation of the Novel Strain Bacillus amyloliquefaciens F9 and Identification of Lipopeptide Extract Components Responsible for Activity against Xanthomonas citri subsp. citri
Authors: Wang Xin , Liang Liqiong , Shao Hang , Ye Xiaoxin , Yang Xiaobei , Chen Xiaoyun , Shi Yu , Zhang Lianhui , Xu Linghui , Wang Junxia
Published: February 2022

Citrus canker, caused by Xanthomonas citri subsp. citri (Xcc), is a quarantine disease that seriously affects citrus production worldwide. The use of microorganisms and their products for biological control has been proven to be effective in controlling Xanthomonas disease. In this study, a novel Xcc antagonistic strain was isolated and identified as Bacillus amyloliquefaciens F9 by morphological and molecular analysis. The lipopeptide extract of B. amyloliquefaciens F9 (F9LE) effectively inhibited the growth of Xcc in an agar diffusion assay and restrained the occurrence of canker lesions in a pathogenicity test under greenhouse conditions. Consistent with these findings, F9LE treatment significantly inhibited the production of extracellular enzymes in Xcc cells and induced cell wall damage, with leakage of bacterial contents revealed by scanning electron microscopy and transmission electron microscopy analyses. In addition, F9LE also showed strong antagonistic activity against a wide spectrum of plant pathogenic bacteria and fungi. Furthermore, using electrospray ionization mass spectrometry analysis, the main antimicrobial compounds of strain F9 were identified as three kinds of lipopeptides, including homologues of surfactin, fengycin, and iturin. Taken together, our results show that B. amyloliquefaciens F9 and its lipopeptide components have the potential to be used as biocontrol agents against Xcc, and other plant pathogenic bacteria and fungi.
Dibutyl Itaconate and Lauryl Methacrylate Copolymers by Emulsion Polymerization for Development of Sustainable Pressure-Sensitive Adhesives
Authors: Casas-Soto Carlos Rafael , Conejo-Dávila Alain Salvador , Osuna Velia , Chávez-Flores David , Espinoza-Hicks José Carlos , Flores-Gallardo Sergio Gabriel , Vega-Rios Alejandro
Published: February 2022

Renewable polymers possess the potential to replace monomers from petrochemical sources. The design and development of polymeric materials from sustainable materials are a technological challenge. The main objectives of this study were to study the microstructure of copolymers based on itaconic acid (IA), di-n-butyl itaconate (DBI), and lauryl methacrylate (LMA); and to explore and to evaluate these copolymers as pressure-sensitive adhesives (PSA). The copolymer synthesis was carried out through batch emulsion radical polymerization, an environmentally friendly process. IA was used in a small fixed amount as a functional comonomer, and LMA was selected due to low glass transition temperature (Tg). The structure of synthesized copolymers was studied by FTIR, 1H-NMR, Soxhlet extraction, and molecular weight analyses by GPC. Furthermore, the viscoelastic and thermal properties of copolymer films were characterized by DMA, DSC, and TGA. The single Tg displayed by the poly(DBI-LMA-IA) terpolymers indicates that statistical random composition copolymers were obtained. Moreover, FTIR and NMR spectra confirm the chemical structure and composition. It was found that a cross-linked microstructure and higher molecular weight are observed with an increase of LMA in the feed led. The Tg and modulus (G′) of the copolymers film can be tuned with the ratio of DBI:LMA providing a platform for a wide range of applications as a biobased alternative to produce waterborne PSA.
HPMC Hydrogel Formation Mechanisms Unveiled by the Evaluation of the Activation Energy
Authors: Perez-Robles Saray , Carotenuto Claudia , Minale Mario
Published: February 2022

Aqueous solutions of hydroxypropyl methylcellulose (HPMC) show inverse thermoreversible gelation, i.e., they respond to small temperature variations exhibiting sol–gel transition during heating, and reversibly gel–sol transition during cooling. According to the pertinent literature on HPMC aqueous systems, at room temperature, the loss modulus (G”) is higher than the storage modulus (G’). During the heating ramp, the viscoelastic response follows a peculiar path: initially, G” and G’ smoothly decrease, then drop to a minimum and finally increase. Eventually, G’ overcomes G”, indicating the gel formation. A recent explanation of this behaviour considers a two-step mechanism: first, phase separation occurs, then fibrils form from a polymer-rich phase and entangle, leading to a three-dimensional network. Based on this, our research focuses on the rheological analysis of the different steps of the sol–gel transition of an HPMC aqueous solution. We perform different viscoelastic tests: thermal ramps, time sweeps, and frequency sweeps at selected characteristic temperatures. We couple classical analysis of the SAOS experiments with an innovative approach based on the evaluation of the activation energy (Ea), made possible by the instrument intrinsic temperature oscillations around the target value. Results show that Ea can be a valid tool that contributes to further clarifying the peculiar microstructural evolution occurring in this kind of thermoreversible gel.
Shield Tunnel Convergence Diameter Detection Based on Self-Driven Mobile Laser Scanning
Authors: Xu Lei , Gong Jian , Na Jiaming , Yang Yuanwei , Tan Zhao , Pfeifer Norbert , Zheng Shunyi
Published: February 2022

The convergence diameter of shield tunnels is detected by ellipse fitting or local curve fitting to cross-section points. However, the tunnel section, which is extruded by an external force, has an irregular elliptical shape, and the waist of the tunnel is often blocked by accessories, resulting in data loss. This study proposes a convergence diameter and radial dislocation detection method based on block-level fitting. The proposed method solves the accuracy degradation caused by the model error and point cloud incompletion. First, the noise points in the tunnel section point cloud are removed using the least trimmed squares method. Second, the tunnel transverse seam is then located using the image edge detection algorithm. Third, the endpoint of the convergence diameter is determined by making a specific segment the center and shifting the detector from the center to the pinpoint. Finally, the convergence diameter and radial dislocation are detected by the endpoints of the segments. The experimental results showed that the absolute detection accuracy of this method was better than 3 mm, and the repeated detection accuracy was better than 2 mm. This result is consistent with prior total station measurements, which are more suitable for practical engineering applications.
Flooding, Food Security and the Sustainable Development Goals in Nigeria: An Assemblage and Systems Thinking Approach
Authors: Echendu Adaku Jane
Published: February 2022

Food is connected to sustainable development goals in numerous ways, as food security is key to achieving sustainable development. The world is currently not on track to achieve the set sustainable development goals (SDGs). In Nigeria, flooding is a recurrent disaster and constitutes a setback to success with the SDGs and sustainable development. Flooding disasters are a threat to food security due to their impact on the food system. This study is an integrative review that explores the link between Nigeria’s flooding, food security, and the SDGs. It adopts an assemblage and systems thinking approach to analyze the impact of flooding on all components of food security. It finds that, despite the impact of flooding on food security, it is not recognized as a threat by policymakers, as evidenced by the lack of mention of disasters in the current Nigeria Agriculture Promotion Policy (APP). Attention is drawn to this oversight in this work by highlighting the interconnections between flooding, food security, and sustainable development. Recommendations on flood mitigation and adaptive practices that can alleviate the negative impact of flooding on food security to enhance the success rate of the SDGs are proffered. This work contributes to the literature by showcasing the impact of flooding on food security and its connection to sustainable development, which is an area that has not received adequate attention in research. The assemblage and system thinking approach adopted brings novelty and allows for a succinct understanding of how flooding impacts all four aspects of food security. This paper serves as the first time the problem has been explored in this manner.
The Impact of the COVID-19 Pandemic on Supply Chains in the Example of Polish Clothing Companies in the Context of Sustainable Development
Authors: Milewska Beata
Published: February 2022

The article presents the impact of the COVID-19 pandemic on the supply chains of Polish clothing companies. The aim of the article is to present the impact of the COVID-19 pandemic on the supply chains of Polish clothing companies, in both the short and long-term, and in the context of sustainable development. The author has been conducting research on logistics and production processes as well as supply chains of Polish clothing companies since 2017. The research results presented in this article on the impact of the pandemic on the functioning of supply chains in this sector of the economy were carried out in 2021. The author conducted telephone interviews with the management of Polish clothing companies of all sizes, both with distributors and producers. She identified disruptions in the supply chains caused by the pandemic (on the supply, production and distribution). She outlined the short-term actions of companies in response to disruptions, as well as long-term changes related to the logistics strategy as a result of the pandemic. The author also presented the ecological and social effects of changes in logistics strategies caused by the pandemic. So far, there has been no research in this industry and this area concerning not only the short-term impact of the pandemic, but also the strategic changes and their impact on sustainable development. Thus, it is a study that fills the existing research gap. The pandemic particularly affected the distribution of clothing, which caused the dynamic development of e-commerce. Because of this, some clothing companies have changed the organization of deliveries to online customers, such as the example presented by the author of the largest Polish clothing company, LPP S.A. The pandemic in apparel companies has also disrupted production and supply. This was especially true for deliveries from countries with low production costs. Despite these disruptions, however, no mass withdrawal from the production of clothing in low-cost countries to Poland has been observed and, according to the surveyed companies, this will not be a long-term consequence of the pandemic. However, if factors that occurred during a pandemic worsen, this could favor the shifting of more production from low-cost countries to local or regional sewing plants. This would enable the application of the Quick Response strategy. Other disruptions that occurred in connection with the pandemic include a reduction in the number of orders for Polish sewing factories, an increase in the prices of materials and packaging, an increase in transport costs and a periodic increase in inventory levels as a reaction of some companies to the disruptions. The disruptions also caused, in some cases, greater volatility in the relationship between individual links in the supply chains, which perhaps will be the next strategic change.
The assessment of effectiveness of a novel antidepressant, Agomelatine on anxiety and depression induced by fluoride intoxication by means of Open-Field and Hot-Plate tests in mouse model (BalB-C)
Authors: KARADEMİR Başaran
Published: February 2022

It is well known that fluoride (F) poisoning causes anxiety and depression, and Agomelatine, an analogue of melatonin, has been reported to be effective on anxiety and depression. Therefore, the aim of this study is to investigate the short-term efficacy of Agomelatine application on anxiety and depression caused by F intoxication via Open-Field and Hot-Plate tests. Forty male BalB-C mice, aged 5-6 months, constituted the research material for this study. Subjects were randomly divided into 4 groups (Healthy-Control, Fluorosis-Control, 25 mg/kg Agomelatine, 50 mg/kg Agomelatine). Healthy-Control group (HC) received tap water, containing 0.3 ± 0.05 mgF/L. Fluorosis-Control group (F) received drinking water containing 40 mgF/L. Other two experimental groups (25 and 50) received drinking water containing 40 mgF/L and a single dose of Agomelatine (25 and 50 mg/kg respectively). The effect of Agomelatine on anxiety and depression induced by high dose F was evaluated using Open-Field and Hot-Plate tests compared to control groups. Fluorosis caused to decrease in Rearing, Grooming and Square numbers of Open-Field test and to increase Defecation counts (P<0.05). Agolematine applications enabled to normalize the Open-Field Test data. Similarly, according to the Hot-Plate findings, low reaction time caused by fluorosis increased in Agomelatine groups (P<0.05). According to those results, psychological improvement was observed in patients with fluorosis compared to the control group after Agomelatine applications. Consequently, according to Open-Field and Hot-Plate tests findings, it could be concluded that Agomelatine has a curative effect on anxiety and depression induced by F toxicity.