bluuebunny/crossref_metadata_2025 huggingface dataset:
Compressive Failure Characteristics of 3D Four-Directional Braided Composites with Prefabricated Holes
Authors: Wang Xin , Li Hanhua , Zhang Yuxuan , Guan Yue , Yan Shi , Zhai Junjun
Published: August 2024

The low delamination tendency and high damage tolerance of three-dimensional (3D) braided composites highlight their significant potential in handling defects. To enhance the engineering potential of three-dimensional four-directional (3D4d) braided composites and assess the failure mode of hole defects, this study introduces a series of 3D4d braided composites with prefabricated holes, studying their compressive properties and failure mechanisms through experimental and finite element methods. Digital image correlation (DIC) was used to monitor the compressive strain on the surface of materials. Scanning acoustic microscope (SAM) and scanning electron microscopy (SEM) were used to characterize the longitudinal compression failure mode inside the material. A macroscopic model is established, and the porous materials are predicted by using the general braided composite material prediction theory. While reducing the forecast cost, the error is also controlled within 21%. The analysis of failure mechanisms elucidates the damage extension mode, and the porous damage tolerance ability aligns closely with the bearing mode of braided material structure. Different braiding angles will lead to different bearing modes of materials. Under longitudinal compression, the average strength loss of 15° specimens is 38.21%, and that of 30° specimens is 8.1%. The larger the braided angle, the stronger the porous damage tolerance. Different types of prefabricated holes will also affect their mechanical properties and damage tolerance.
A Review of Friction in Low-Stress Mechanics of Fibrous Flexible Materials
Authors: Luo Liang , Stylios George
Published: August 2024

The structure of a fabric is a highly complex assembly of fibres, which have order and regularity as well as disorder and randomness. The complexity of the structure poses challenges in defining its mechanical behaviour, particularly at low stress, which is typical to end uses. The coexistence of multiple deformations and the high degree of nonlinearity of the fabric due to fibre friction make its stress–strain relationship complicated. This article reviews the literature on friction related to the low-stress mechanics of fabrics, and it establishes its range and regularity to help with finding a unified reference model, in which although the physical meanings of fabric tensile, shear, and bending vary, they follow consistent mathematical regularities. So, invariably, their disorder and randomness needed in defining them can be obtained from fabric measurement data. It defines the scope and patterns of friction to facilitate the development of a unified reference model. It argues that although the physical interpretations of fabric tensile, shear, and bending characteristics may differ, they adhere to consistent mathematical regularities within this model, and hence extracting disorder and randomness from fabric measurement data may be achievable. This paper concludes with a number of recommendations, postulating that hysteresis caused by friction between fibres in a fabric is an important component of mechanical information, and it coexists with its purely elastic component, but it cannot be obtained directly by measurement. Seeking means to effectively decompose the friction hysteresis and pure elastic components contained in fabric mechanics measurement data will provide an accurate characterization of fabric mechanical properties and hence an accurate modelling and simulation of its behaviour, and will impact many traditional and industrial textile end uses.
X-IGA Used for Orthotropic Material Crack Growth
Authors: Berrada Gouzi Mohammed , El Khalfi Ahmed , Vlase Sorin , Scutaru Maria Luminita
Published: August 2024

In this paper, we propose a new approach for numerically simulating the growth of cracks in unidirectional composite materials, termed extended isogeometric analysis, evaluating the maximum stress intensity factor and T-stress. To validate our approach, we used a small anisotropic plate with two edge cracks, beginning with formulating the governing equations based on the energy integral method, Stroh’s Formula, and the Elastic Law describing the behaviour of anisotropic materials, while considering boundary conditions and initial states. A MATLAB code was developed to solve these equations numerically and to post-process the tensile stress and the stress intensity factor (SIF) in the first mode. The results for the SIF closely match those obtained using the extended finite element method (X-FEM), with a discrepancy of only 0.0021 Pa·m0.5. This finding underscores the credibility of our approach. The extended finite element method has demonstrated robustness in predicting crack propagation in composite materials in recent years, leading to its adoption by several widely used software packages in various industries.
Foreign Body Reaction to Ion-Beam-Treated Polyurethane Implant
Authors: Chudinov Vyacheslav S. , Shardakov Igor N. , Litvinov Valery V. , Solodnikov Sergey Y. , Chudinova Elena Y. , Kondyurina Irina V. , Kondyurin Alexey V.
Published: August 2024

All artificial materials used for implantation into an organism cause a foreign body reaction. This is an obstacle for a number of medical technologies. In this work, we investigated the effect of high-energy ion bombardment on polyurethane for medical purposes and the reaction of body tissues to its insertion into the mouse organism. An analysis of the cellular response and shell thickness near the implant showed a decrease in the foreign body reaction for implants treated with high-energy ions compared to untreated implants. The decrease in the reaction is associated with the activation of the polyurethane surface due to the formation on the surface layer of condensed aromatic clusters with unbonded valences on the carbon atoms at the edges of such clusters and the covalent attachment of the organism’s own proteins to the activated surface of the implant. Thus, immune cells do not identify the implant surface coated with its own proteins as a foreign body. The deactivation of free valences at the edges of aromatic structures due to the storage of the treated implant before surgery reduces surface activity and partially restores the foreign body response. For the greatest effect in eliminating a foreign body reaction, it is recommended to perform the operation immediately after treating the implant with high-energy ions, with minimal contact of the treated surface with any materials.
Rheological Changes in Bio-Based Filaments Induced by Extrusion-Based 3D Printing Process
Authors: Patti Antonella , Acierno Stefano
Published: August 2024

In this work, the authors investigated the impact of extrusion-based printing process on the structural characteristics of bio-based resins through rheological measurements. Two commercially available filaments made from unfilled and wood-filled polylactide (PLA) polymers were considered. Three-dimensional specimens were prepared by printing these filaments under various operating conditions, i.e., changing the extruder temperature and printing rate, and examined using time sweep tests. Specific cycle rheological testing was conducted on pelletized filaments to simulate temperature changes in the printing process. The rheological characteristics of unprocessed materials, in terms of storage (G′) and loss (G″) moduli, were found to be slightly affected by temperature changes. For a pure polymer, the G′ slope at a low frequency decreased over time, showing that the polymer chains evolved from a higher to a lower molecular weight. For wood-filled materials, the G′ slope rose over the testing time, emphasizing the formation of a percolated network of structured filler within the matrix. On the other side, the rheological parameters of both materials were strongly impacted by the printing extrusion and the related conditions. At lower nozzle temperatures (200 °C), by decreasing the printing speed, the G′ and G″ curves became increasingly different with respect to unprocessed resin; whereas at higher nozzle temperatures (220 °C), the influence of the printing speed was insignificant, and all curves (albeit distant from those of unprocessed matrix) mainly overlapped. Considerations on degradation kinetics of both materials during the printing process were also provided by fitting experimental data of complex viscosity with linear correlation over time.
Mechanical Properties and Microanalytical Study of Concrete Reinforced with Blended Corn Straw and Scrap Steel Fibers
Authors: He Jingjing , Sun Chuanwu , Wang Xuezhi
Published: August 2024

Fiber concrete exhibits superior performance in various aspects compared to plain concrete and has been widely researched and applied worldwide. However, many industrially made fibers are expensive, and their cost has to be considered before use; thus, it would be economically valuable to find inexpensive fibers with excellent properties to make fiber concrete. Rural areas have many rich straw resources to be disposed of; at the same time, the rapid development of the automobile industry has introduced a large number of used tires containing steel wire with a very low reuse rate. These two low-cost materials can be processed to make fibers, making the study of mechanical properties regarding their incorporation into concrete practically significant for reducing the cost of fiber concrete. Based on this, a three-factor, three-level orthogonal test was conducted to investigate the effects of different dosages of corn straw fibers and scrap steel fibers, as well as the water–cement ratio, on the mechanical properties of concrete. The optimum level of each factor for blended straw–waste-steel-fiber concrete with different mechanical properties was obtained using the polar and ANOVA methods. It was found that the compressive strength, splitting tensile strength, flexural strength, and impact resistance of the specimens after fiber dosing were better than those of plain concrete specimens with the same water–cement ratio. The maximum improvement was 14.96% in cubic compressive strength, 42.90% in tensile strength, and 16.30% in flexural strength, while the maximum improvement in impact energy consumption at the final crack was 228.03%. Combined with SEM microanalysis, the two fibers formed a stronger whole with the C-S-H gel. When the specimen was subjected to load, the two fibers were able to withstand part of the load, thus enhancing the load-bearing capacity. Finally, the optimal mix ratio of blended straw–scrap-steel-fiber concrete was determined to be 0.8% corn straw fibers by volume, 0.6% scrap steel fibers by volume, and a 0.45 water–cement ratio by combining the weights of the levels of each factor under its four different mechanical properties through hierarchical analysis. This analysis of mechanical properties provides a reference for practical applications in future projects.
A Stock Optimization Problem in Finance: Understanding Financial and Economic Indicators through Analytical Predictive Modeling
Authors: Chakraborty Aditya , Tsokos Chris
Published: August 2024

Given the significant impact of healthcare stock changes on the global economy, including its GDP and other financial factors, we endeavored to create an analytical prediction model for forecasting the annual percentage change of these stocks. Our model, which is nonlinear, incorporates five key discoveries. We focused on predicting the average weekly closing price (pWCP) of AbbVie Inc. (North Chicago, IL, USA)’s healthcare stock (ABBV) from 1 August 2017 to 31 December 2019. The stock was chosen based on the low beta risk, high dividend yield, and high yearly percentage return criteria. Alongside predicting the weekly stock price, our model identifies the individual indicators and their interactions that notably influence the response. These indicators were ranked based on their contribution percentages to the response. The validity of the model was justified based on the root mean square error (RMSE) and R2 value by performing 10-fold cross-validation. Furthermore, an optimization process using the desirability function was implemented to determine the optimal values of the indicators that maximize the response, along with the 95% confidence and 95% prediction interval. We also visually depicted the optimal ranges of any two indicators that affect the response AWCP. In our evaluation, we compared the original and predicted responses of AWCP using our analytical model. The results demonstrated a close alignment between the two sets of observations, highlighting the high accuracy of our model. Beyond these findings, our model provides additional valuable insights into the subject area. It has undergone thorough validation and testing, confirming its high quality and the precision of our weekly stock price predictions. The information derived from the modeling and analysis is important for constructive and accurate decision-making for individual investors, portfolio managers, and financial institutions concerning the financial and economic aspects of the healthcare industry. By identifying the optimum values of the controllable contributors through the optimization process, financial institutions can make the strategic changes needed for the company’s long-term viability.
Linearly Implicit Conservative Schemes with a High Order for Solving a Class of Nonlocal Wave Equations
Authors: Chen Shaojun , Fu Yayun
Published: August 2024

This paper introduces a class of novel high-accuracy energy-preserving numerical schemes tailored specifically for solving the nonlocal wave equation with Gaussian kernel, which plays a fundamental role in various scientific and engineering applications where traditional local wave equations are inadequate. Comprehensive numerical experiments, including comparisons with analytical solutions and benchmark tests, demonstrate the superior accuracy and energy-preserving capabilities of the proposed schemes. These high-accuracy energy-preserving schemes represent a valuable tool for researchers and practitioners in fields reliant on nonlocal wave equation modeling, offering enhanced predictive capabilities and robustness in capturing complex wave dynamics while ensuring long-term numerical stability.
Clustering Empirical Bootstrap Distribution Functions Parametrized by Galton–Watson Branching Processes
Authors: Varmann Lauri , Mouriño Helena
Published: August 2024

The nonparametric bootstrap has been used in cluster analysis for various purposes. One of those purposes is to account for sampling variability. This can be achieved by obtaining a bootstrap approximation of the sampling distribution function of the estimator of interest and then clustering those distribution functions. Although the consistency of the nonparametric bootstrap in estimating transformations of the sample mean has been known for decades, little is known about how it carries over to clustering. Here, we investigated this problem with a simulation study. We considered single-linkage agglomerative hierarchical clustering and a three-type branching process for parametrized transformations of random vectors of relative frequencies of possible types of the index case of each process. In total, there were nine factors and 216 simulation scenarios in a fully-factorial design. The ability of the bootstrap-based clustering to recover the ground truth clusterings was quantified by the adjusted transfer distance between partitions. The results showed that in the best 18 scenarios, the average value of the distance was less than 20 percent of the maximum possible distance value. We noticed that the results most notably depended on the number of retained clusters, the distribution for sampling the prevalence of types, and the sample size appearing in the denominators of relative frequency types. The comparison of the bootstrap-based clustering results with so-called uninformed random partitioning results showed that in the vast majority of scenarios considered, the bootstrap-based approach led, on average, to remarkably lower classification errors than the random partitioning.
Adaptive Visual Control for Robotic Manipulators with Consideration of Rigid-Body Dynamics and Joint-Motor Dynamics
Authors: Chen Zhitian , Wen Weijian , Yang Weijun
Published: August 2024

A novel cascade visual control scheme is proposed to tailor for electrically driven robotic manipulators that operate under kinematic and dynamic uncertainties, utilizing an uncalibrated stationary camera. The proposed control approach incorporates adaptive weight radial basis function neural networks (RBFNNs) to learn the behaviors of the uncertain dynamics of the robot and the joint actuators. The controllers are designed to nullify the approximation error and mitigate unknown disturbances through an integrated robust adaptive mechanism. A major advantage of the proposed approach is that prior knowledge of the dynamics of the robotic manipulator and its actuator is no longer required. The controller autonomously assimilates the robot and actuator dynamics online, thereby obviating the need for fussy regression matrix derivation and advance dynamic measurement to establish the adaptive dynamic parameter update algorithm. The proposed scheme ensures closed-loop system stability, bounded system states, and the convergence of tracking errors to zero. Simulation results, employing a PUMA manipulator as a testbed, substantiate the viability of the proposed control policy.
Extraction Optimization and Anti-Tumor Activity of Polysaccharides from Chlamydomonas reinhardtii
Authors: Liang Zhongwen , Xiong Lan , Zang Ying , Tang Zhijuan , Shang Zhenyu , Zhang Jingyu , Jia Zihan , Huang Yanting , Ye Xiaoyu , Liu Hongquan , Li Mei
Published: August 2024

Chlamydomonas reinhardtii polysaccharides (CRPs) are bioactive compounds derived from C. reinhardtii, yet their potential in cancer therapy remains largely unexplored. This study optimized the ultrasound-assisted extraction conditions using response surface methodology and proceeded with the isolation and purification of these polysaccharides. The optimal extraction conditions were identified as a sodium hydroxide concentration of 1.5%, ultrasonic power of 200 W, a solid-to-liquid ratio of 1:25 g/mL, an ultrasonic treatment time of 10 min, and a water bath duration of 2.5 h, yielding an actual extraction rate of 5.71 ± 0.001%, which closely aligns with the predicted value of 5.639%. Infrared analysis revealed that CRP-1 and CRP-2 are α-pyranose structures containing furoic acid, while CRP-3 and CRP-4 are β-pyranose structures containing furoic acid. Experimental results demonstrated that all four purified polysaccharides inhibited the proliferation of cervical (HeLa) hepatoma (HepG-2) and colon (HCT-116) cancer cells, with CRP-4 showing the most significant inhibitory effect on colon cancer and cervical cancer, achieving inhibition rates of 60.58 ± 0.88% and 40.44 ± 1.44%, respectively, and significantly reducing the migration of HeLa cells. DAPI staining confirmed that the four purified polysaccharides inhibit cell proliferation and migration by inducing apoptosis in HeLa cells. CRP-1 has the most significant inhibitory effect on the proliferation of liver cancer cells. This study not only elucidates the potential application of C. reinhardtii polysaccharides in cancer therapy but also provides a scientific basis for their further development and utilization.
Endoscopic Features of Chronic Rhinosinusitis in Patients with Gastroesophageal Reflux Disease
Authors: Sagandykova Kalamkas , Papulova Nataliya , Azhenov Talapbek , Darbekova Aliya , Aigozhina Bayan , Lechien Jerome R.
Published: August 2024

Chronic rhinosinusitis (CRS) is a complex inflammatory condition affecting the nasal and paranasal sinus mucosa. Gastroesophageal reflux disease (GERD) has been implicated as a potential exacerbating factor in CRS, but the specific endoscopic features of nasopharyngeal pathology in this context remain poorly understood. Background and Objectives: Chronic rhinosinusitis is a multifactorial disease with various underlying etiologies, including inflammation, anatomical factors, and environmental triggers. While gastroesophageal reflux disease has been suggested as a potential contributor to chronic rhinosinusitis, the specific endoscopic features indicative of nasopharyngeal pathology in CRS patients with GERD symptoms have not been clearly elucidated. Our aim is to identify specific endoscopic features of nasopharyngeal pathology in patients with CRS associated with GERD symptoms and to propose a method for assessing the influence of gastroesophageal reflux disease on the mucosal layer of the nose and nasopharynx. Materials and Methods: We conducted a cross-sectional observational study involving 521 adult patients presenting with symptoms suggestive of CRS. From this cohort, 95 patients with the highest scores on the Reflux Symptom Index (RSI) and Reflux Symptom Score-12 (RSS-12) questionnaires were selected as the main group. Endoscopic examinations were performed to assess the nasal and nasopharyngeal mucosa. Results: Our study revealed significant alterations in the nasopharyngeal mucosa of patients with CRS associated with GERD symptoms. Increased vascularity of the nasopharyngeal mucosa was observed in 91 patients (95.7%), while hypertrophy was noted in 83 patients (87.4%). Mucus was present in the nasopharynx of 77 patients (81.1%), exhibiting varying characteristics of color and consistency. Asymmetric hypertrophy of the oropharyngeal mucosa was noted in 62 patients (65.3%). Conclusions: We propose a method for assessing the influence of gastroesophageal reflux disease on the mucosal layer of the nose and nasopharynx, which may aid in diagnostic and management decisions. Further research is warranted to explore the potential impact of GERD symptoms on the course and severity of CRS exacerbations.
Forgotten Biliary Plastic Stents: Complications, Management, and Clinical Outcomes
Authors: Elsebaey Mohamed A. , Enaba Mohamed Elsayed , Elashry Heba , Elbedewy Tamer A. , El Nakib Ahmed Mohamed , Elhadidy Ahmed A. , Sarhan Mohamed Elsayed , Elrefaey Waleed , Hagag Rasha Youssef , Alqifari Abdullah Mohammed , Elsokkary Assem Mohamed , Alabd Mohamed Abd Allah , Abdulrahim Abdulrashid Onimisi , Abo-Amer Yousry Esam-Eldin , Abo-Elfetoh Ashraf Rafat , Mahfouz Mohammad Shaaban , Saleh Mohamed , Mohamed Ahmed Abdelhaleem , Ismail Amro Abdelaziz Mohammed
Published: August 2024

Background and Objectives: Endoscopic biliary plastic stenting is a safe and effective temporary therapeutic modality used in various benign biliary disorders. Long-term indwelling stents for more than one year without retrieval are termed “forgotten biliary stents”. In clinical practice, the forgotten stents are underestimated and the majority of data were obtained from case reports. The aim of this study was to determine the forgotten-biliary-plastic-stent-related complications, their management, and the patients’ clinical outcomes. Materials and Methods: This retrospective study was performed at three hospitals during the period from January 2021 to December 2023. In total, 577 patients with biliary plastic stents—inserted for a variety of benign biliary conditions—were included. They were divided into two groups, as follows: group 1 included 527 patients who had biliary stents removed within 3 months, and group 2 included 50 patients with biliary stents retrieved after one year of their deployment. The stent-related complications (e.g., acute cholangitis, stent clogging, distal stent migration, new common bile duct (CBD) stone formation, and proximal stent migration) and the endoscopic management success rate were evaluated. Results: Irretrievable CBD stones were the main indication for biliary plastic stenting in both groups. The stent-related complications, number of endoscopic sessions, and hospital admissions were significantly higher in the patients with forgotten biliary stents than those with stent removal within 3 months. All the study patients were successfully managed endoscopically with uneventful outcomes. Conclusions: Based on this retrospective study, non-adherence to the endoscopists’ instructions is the main reason for retained biliary stents for more than one year. The patients with forgotten stents had significantly higher complication rates, a higher number of endoscopic sessions, and a higher number of hospital admissions than those with stents that were retrieved in the scheduled time. All patients were managed endoscopically with a technical success rate of 100%, and with no complication-related mortality.
Propionic Acidemia, Methylmalonic Acidemia, and Cobalamin C Deficiency: Comparison of Untargeted Metabolomic Profiles
Authors: Sidorina Anna , Catesini Giulio , Sacchetti Elisa , Rizzo Cristiano , Dionisi-Vici Carlo
Published: August 2024

Methylmalonic acidemia (MMA), propionic acidemia (PA), and cobalamin C deficiency (cblC) share a defect in propionic acid metabolism. In addition, cblC is also involved in the process of homocysteine remethylation. These three diseases produce various phenotypes and complex downstream metabolic effects. In this study, we used an untargeted metabolomics approach to investigate the biochemical differences and the possible connections among the pathophysiology of each disease. The significantly changed metabolites in the untargeted urine metabolomic profiles of 21 patients (seven MMA, seven PA, seven cblC) were identified through statistical analysis (p < 0.05; log2FC > |1|) and then used for annotation. Annotated features were associated with different metabolic pathways potentially involved in the disease’s development. Comparative statistics showed markedly different metabolomic profiles between MMA, PA, and cblC, highlighting the characteristic species for each disease. The most affected pathways were related to the metabolism of organic acids (all diseases), amino acids (all diseases), and glycine and its conjugates (in PA); the transsulfuration pathway; oxidative processes; and neurosteroid hormones (in cblC). The untargeted metabolomics study highlighted the presence of significant differences between the three diseases, pointing to the most relevant contrast in the cblC profile compared to MMA and PA. Some new biomarkers were proposed for PA, while novel data regarding the alterations of steroid hormone profiles and biomarkers of oxidative stress were obtained for cblC disease. The elevation of neurosteroids in cblC may indicate a potential connection with the development of ocular and neuronal deterioration.
Diversity of Microbial Functional Genes Promotes Soil Nitrogen Mineralization in Boreal Forests
Authors: Zhang Xiumin , Zhang Huayong , Wang Zhongyu , Tian Yonglan , Tian Wang , Liu Zhao
Published: August 2024

Soil nitrogen (N) mineralization typically governs the availability and movement of soil N. Understanding how factors, especially functional genes, affect N transformations is essential for the protection and restoration of forest ecosystems. To uncover the underlying mechanisms driving soil N mineralization, this study investigated the effects of edaphic environments, substrates, and soil microbial assemblages on net soil N mineralization in boreal forests. Field studies were conducted in five representative forests: Larix principis-rupprechtii forest (LF), Betula platyphylla forest (BF), mixed forest of Larix principis-rupprechtii and Betula platyphylla (MF), Picea asperata forest (SF), and Pinus sylvestris var. mongolica forest (MPF). Results showed that soil N mineralization rates (Rmin) differed significantly among forests, with the highest rate in BF (p < 0.05). Soil properties and microbial assemblages accounted for over 50% of the variability in N mineralization. This study indicated that soil environmental factors influenced N mineralization through their regulatory impact on microbial assemblages. Compared with microbial community assemblages (α-diversity, Shannon and Richness), functional genes assemblages were the most important indexes to regulate N mineralization. It was thus determined that microbial functional genes controlled N mineralization in boreal forests. This study clarified the mechanisms of N mineralization and provided a mechanistic understanding to enhance biogeochemical models for forecasting soil N availability, alongside aiding species diversity conservation and fragile ecosystem revitalization in boreal forests.
Catalytic Degradation of Bisphenol A with a Magnetically Recoverable Geopolymer Composite Using Coal Gangue
Authors: Shi Qishun , Wu Danlei , Guo Chunli , Ma Jianchao
Published: August 2024

The widespread presence and use of Bisphenol A (BPA) in aquatic environments has caused significant ecological damage. Coal gangue (CG), a byproduct of coal mining, poses a major environmental concern due to its vast land occupation and potential for pollution. A magnetic recyclable geopolymer (MnFe2O4-CGP) using coal gangue geopolymer (CGP) as the carrier was successfully synthesized and was evaluated for its ability to Fenton-like degrade BPA. The characterization techniques revealed the successful incorporation of spherical MnFe2O4 onto the CGP surface and that CGP serves as an excellent platform for the immobilization and dispersion of MnFe2O4. The degradation rate reached 100% within 60 min at pH = 5, 15 mmol/L H2O2, 0.6 g/L catalyst, and 50 mg/L BPA, significantly higher than MnFe2O4 and CGP alone. It was indicated that the degradation rate of BPA in MnFe2O4-CGP composites was 0.1121 min−1, which was consistent with the first-order kinetic model. The saturation magnetization of MnFe2O4-CGP was measured to be 10.96 emu/g, enabling convenient recovery. MnFe2O4-CGP exhibited excellent stability, as the degradation rate of BPA remained above 95% even after five reaction cycles. This efficiency may be due to the MnFe2O4-CGP induced generation of reactive radicals. Quenching and EPR radical trapping experiments unequivocally confirmed that the reactive radical was hydroxyl radical (•OH). These results indicate that MnFe2O4-CGP has potential application prospects as a magnetic recyclable geopolymer composite in Fenton-like catalysis.
An Outlook on Platinum-Based Active Ingredients for Dermatologic and Skincare Applications
Authors: Li Shining , Liu Yizhou , Wu Ying , Ren Lu , Lu Yongjie , Yamaguchi Shuji , Lu Qipeng , Hu Chuangang , Li Dongcui , Jiang Naisheng
Published: August 2024

Platinum-based materials exhibit a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and pro-collagen synthesis properties, making them particularly useful for various biomedical applications. This review summarizes the biological effects and therapeutic potential of platinum-based active ingredients in dermatological and skincare applications. We discuss their synthesis methods and their antioxidant, anti-inflammatory, antimicrobial, and collagen synthesis properties, which play essential roles in treating skin conditions including psoriasis and acne, as well as enhancing skin aesthetics in anti-aging products. Safety and sustainability concerns, including the need for green synthesis and comprehensive toxicological assessments to ensure safe topical applications, are also discussed. By providing an up-to-date overview of current research, we aim to highlight both the potential and the current challenges of platinum-based active ingredients in advancing dermatology and skincare solutions.
Cancer Treatment Using Nanofibers: A Review
Authors: Khan Muhammad Qamar , Alvi Muhammad Abbas , Nawaz Hafiza Hifza , Umar Muhammad
Published: August 2024

Currently, the number of patients with cancer is expanding consistently because of a low quality of life. For this reason, the therapies used to treat cancer have received a lot of consideration from specialists. Numerous anticancer medications have been utilized to treat patients with cancer. However, the immediate utilization of anticancer medicines leads to unpleasant side effects for patients and there are many restrictions to applying these treatments. A number of polymers like cellulose, chitosan, Polyvinyl Alcohol (PVA), Polyacrylonitrile (PAN), peptides and Poly (hydroxy alkanoate) have good properties for the treatment of cancer, but the nanofibers-based target and controlled drug delivery system produced by the co-axial electrospinning technique have extraordinary properties like favorable mechanical characteristics, an excellent release profile, a high surface area, and a high sponginess and are harmless, bio-renewable, biofriendly, highly degradable, and can be produced very conveniently on an industrial scale. Thus, nanofibers produced through coaxial electrospinning can be designed to target specific cancer cells or tissues. By modifying the composition and properties of the nanofibers, researchers can control the release kinetics of the therapeutic agent and enhance its accumulation at the tumor site while minimizing systemic toxicity. The core–shell structure of coaxial electrospun nanofibers allows for a controlled and sustained release of therapeutic agents over time. This controlled release profile can improve the efficacy of cancer treatment by maintaining therapeutic drug concentrations within the tumor microenvironment for an extended period.
An Assessment of Behavioral Risk Factors in Oncology Patients
Authors: Mititelu Magdalena , Licu Monica , Neacșu Sorinel Marius , Călin Mariana Floricica , Matei Silvia Raluca , Scafa-Udriște Alexandru , Stanciu Tiberius Iustinian , Busnatu Ștefan Sebastian , Olteanu Gabriel , Măru Nicoleta , Boroghină Steluța Constanța , Lupu Sergiu , Coliță Anca , Mănescu Mihaela Isabela , Lupu Carmen Elena
Published: August 2024

An evaluation of the behavioral risk factors that contribute to the incidence and evolution of cancer in oncology patients was conducted through a cross-sectional study using a questionnaire completed by 206 patients (101 men and 105 women) diagnosed with various types of cancer. These patients were selected from different oncology centers in Romania, located in Bucharest and Constanta. Among the respondents, 91 are of normal weight, 12 are underweight, 62 are overweight, and 41 are obese, with overweight individuals predominating (p = 0.799). Regarding the presence of behavioral risk factors that can aggravate oncological pathology, it is found that 10 respondents consume alcohol daily, 36 consume it weekly with varying frequencies (p = 0.012), 26 respondents smoke excessively daily, and 12 respondents smoke 1–2 cigarettes daily (p = 0.438). Additionally, 40 respondents rarely engage in physical activity, and 71 respondents do not engage in physical activity at all as they do not typically participate in sports (p = 0.041). Thus, respondents with colon cancer tend to consume sweets, pastries and even fast food or fried foods more often, while the daily consumption of vegetables and fruits is insufficient, according to the recommendations of nutrition guidelines (a minimum of four portions per day). The analysis found that smoking and excessive alcohol consumption were associated with an increased incidence of lung and liver cancer. The lack of regular physical activity was identified as a risk factor for breast and colon cancer. An unhealthy diet, characterized by a low consumption of fruits and vegetables and high intake of processed foods, was correlated with a higher incidence of colorectal cancer. Additionally, non-adherence to medical advice was associated with poorer clinical outcomes and faster disease progression. The majority of respondents who declared that they did not feel an improvement in their state of health in the last period were among those who stated that they did not fully comply with the oncologist’s recommendations. Identifying and modifying behavioral risk factors can play a crucial role in cancer prevention and in improving the prognosis and quality of life of cancer patients.
Relationship between Improvement in Physical Activity and Three Nutritional Assessment Indicators in Patients Admitted to a Convalescent Rehabilitation Ward
Authors: Tamamura Yusuke , Hachiuma Chihiro , Matsuura Michiko , Shiba Sumiko , Nishikimi Toshio
Published: August 2024

We investigated the relationship between three nutritional indicators, the Mini Nutritional Assessment-Short Form (MNA-SF), Geriatric Nutritional Risk Index (GNRI), and Controlling Nutrition Status (CONUT), and physical activity at discharge in patients admitted to convalescent rehabilitation wards. The study included 1601 patients (77 ± 12 years, male 46.2%) discharged from convalescent rehabilitation wards between April 2018 and September 2023. MNA-SF, GNRI, and CONUT scores were obtained on admission. Patients were divided into two groups according to their level of Functional Independence Measure (FIM) walk score at discharge. The walking group (n = 1181, FIM walk score ≥ 5, 76 ± 13 years, male 47.2%) was significantly younger than the wheelchair group (n = 420, 79 ± 12 years, FIM walk score < 5, male 43.8%) and had significantly higher MNA-SF (6.5 ± 2.5 vs. 4.7 ± 2.4) and GNRI (93.1 ± 12.4 vs. 86.7 ± 10.9) scores and significantly lower CONUT (3.1 ± 2.3 vs. 3.9 ± 2.3) scores than the wheelchair group (all p < 0.01). Multivariate logistic regression analysis showed that age, handgrip strength, Functional Oral Intake Scale, and MNA-SF score were independently associated with walking ability at discharge (all p < 0.01). In addition, MNA-SF scores were independently associated with Rehabilitation Effectiveness. These results suggest that nutritional status, particularly MNA-SF scores on admission, is associated with improvement of physical activity at discharge.
The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus
Authors: Tang Diana , Shekhawat Giriraj S. , Burlutsky George , Mitchell Paul , Gopinath Bamini
Published: August 2024

Background: Tinnitus is the phantom perception of sound in the ears or head which may result from inflammation of the auditory pathway. A healthy diet consisting of a range of vitamins and minerals may be protective against tinnitus. This study aims to determine the association between intakes of dietary vitamins and minerals and the prevalence and incidence of tinnitus over 10 years. Methods: In this longitudinal cohort study of 2947 participants (aged ≥ 50 years), 935 (32%) cases of tinnitus were identified and included in prevalence analyses. The remaining 2012 participants were followed to establish 10-year incidence of tinnitus. A validated semi-quantitative food frequency questionnaire was used to determine intakes of dietary vitamins and minerals. Results: No significant associations with tinnitus prevalence were found. However, iron and zinc were significantly associated with incident tinnitus. There was a 44% (multivariate-adjusted HR: 1.44, 95% CI: 1.07–1.93) increased risk of developing incident tinnitus over 10 years with lower zinc intakes and a 35% increased risk with lower iron intakes (multivariate-adjusted HR: 1.35, 95% CI: 1.00–1.80). Conclusion: Higher intakes of zinc and iron were significantly associated with lower tinnitus risk. Due to a lack of comparable high-quality data, future research studies should include robust study designs.
Effectiveness of Resistance Training Program on Body Composition in Adults Following Vegan Diet versus Omnivorous Diet; Developed in Mobile Health Modality
Authors: Cárcamo-Regla Richar , Zapata-Lamana Rafael , Ochoa-Rosales Carolina , Martorell Miquel , Carrasco-Marín Fernanda , Molina-Recio Guillermo
Published: August 2024

Background: The vegan diet (VEGD) has gained popularity in recent years for ecological and ethical reasons, as well as for its health benefits. In addition to the type of diet, the resistance training program (RTP) plays a fundamental role as one of the main natural anabolic stimuli to increase musculoskeletal mass and reduce fat mass. Methods: The study was a 16-week non-randomized controlled clinical trial consisting of three RTP sessions per week. The sample included 70 Chilean individuals, aged between 18 and 59 years, who had been following a VEGD or omnivorous diet (OMND) for the past 6 months. Four groups were established: Vegan Diet Resistance Training Program (VEGD-RTP), Vegan Diet Control (VEGD-C), Omnivorous Diet Resistance Training Program (OMND-RTP), and Omnivorous Diet Control (OMND-C). Results: The sample consisted of 47 women and 23 men, with a mean age of 30.1 (±8.6) years. A reduction of 1.20% in the percentage of fat mass (%FM) was observed in the VEGD-RTP group (r = 0.554, p = 0.016), as well as a reduction of 0.70 kg in kilograms of fat mass (KFM) (r = 0.480, p = 0.036). The OMND-RTP group decreased %FM by 0.90% (r = 0.210, p = 0.432) and KFM by 0.50 kg (r = 0.109, p = 0.683). Conclusions: RTP combined with VEGD or OMND significantly reduced the percentage of fat mass, although its effect was more significant in the VEGD-RTP participants.
Content Validation of the Self-Medication Scale and Trust in Online Resources: Deepening Digital Access to Health
Authors: Cotobal Calvo Eva Manuela , Bocchino Anna , Mata-Pérez Concepción , Cruz-Barrientos Alberto , Naranjo-Márquez María , Palazón-Fernández José Luis
Published: August 2024

(1) Background: The rise of online health resources and AI has reshaped the diagnosis and treatment of disease, altering the relationship between patients and healthcare professionals and encouraging self-medication. However, questionnaires validated in the literature on self-medication seem to lack questions on the possible causes that induce such behaviors, including items that explore trust toward websites and artificial intelligence. The aim of this study is to design and validate the content of a questionnaire designed to assess self-medication in health professionals, delving into the underlying etiologies, the pharmacological categories involved and the degree of confidence placed in clinical assessments derived from AI tools. (2) Methods: Validation study of the content of an instrument consisting of two phases: 1. The content validation phase involved evaluation by a selected group of health experts, who, using a Likert-type scale, analyzed the clarity, coherence and relevance of the items. 2. Pilot study of health professionals who have indicated the practice of self-administration of medications. (3) Results: In the first phase of the study, the experts considered most of the questionnaire items to be clear, representative and consistent with the construct to be measured. In its second phase, the preliminary results of our pilot study suggest a significant trend toward self-medication among healthcare workers, along with a strong inclination to use online resources to search for health-related information. (4) Conclusions: The development of a validated instrument to measure the influence of the different causes that lead healthcare personnel to practice self-medication, guaranteeing validity and efficacy, allows us to establish strategies to reduce this growing problem.
The Physiological and Molecular Mechanisms of Exogenous Melatonin Promote the Seed Germination of Maize (Zea mays L.) under Salt Stress
Authors: Wang Jiajie , Yan Di , Liu Rui , Wang Ting , Lian Yijia , Lu Zhenzong , Hong Yue , Wang Ye , Li Runzhi
Published: August 2024

Salt stress caused by high concentrations of Na+ and Cl- in soil is one of the most important abiotic stresses in agricultural production, which seriously affects grain yield. The alleviation of salt stress through the application of exogenous substances is important for grain production. Melatonin (MT, N-acetyl-5-methoxytryptamine) is an indole-like small molecule that can effectively alleviate the damage caused by adversity stress on crops. Current studies have mainly focused on the effects of MT on the physiology and biochemistry of crops at the seedling stage, with fewer studies on the gene regulatory mechanisms of crops at the germination stage. The aim of this study was to explain the mechanism of MT-induced salt tolerance at physiological, biochemical, and molecular levels and to provide a theoretical basis for the resolution of MT-mediated regulatory mechanisms of plant adaptation to salt stress. In this study, we investigated the germination, physiology, and transcript levels of maize seeds, analyzed the relevant differentially expressed genes (DEGs), and examined salt tolerance-related pathways. The results showed that MT could increase the seed germination rate by 14.28–19.04%, improve seed antioxidant enzyme activities (average increase of 11.61%), and reduce reactive oxygen species accumulation and membrane oxidative damage. In addition, MT was involved in regulating the changes of endogenous hormones during the germination of maize seeds under salt stress. Transcriptome results showed that MT affected the activity of antioxidant enzymes, response to stress, and seed germination-related genes in maize seeds under salt stress and regulated the expression of genes related to starch and sucrose metabolism and phytohormone signal transduction pathways. Taken together, the results indicate that exogenous MT can affect the expression of stress response-related genes in salt-stressed maize seeds, enhance the antioxidant capacity of the seeds, reduce the damage induced by salt stress, and thus promote the germination of maize seeds under salt stress. The results provide a theoretical basis for the MT-mediated regulatory mechanism of plant adaptation to salt stress and screen potential candidate genes for molecular breeding of salt-tolerant maize.
Analysis of the Substituent Distribution in Carboxymethyl-1,4-glucans on Different Structural Levels—An Ongoing Challenge
Authors: Steingaß Franziska , Adden Anne , Mischnick Petra
Published: August 2024

Carboxymethylglucans (CMGs) are widely used semisynthetic polyelectrolytes, e.g., for pharmaceuticals. They are produced in heterogeneous processes on activated starch granules or cellulose fibers. In contrast to neutral ether derivatives, a lower DS in the range, commonly between 0.6 and 1.2, is sufficient to achieve the water solubility of CM cellulose. The high proportion of unsubstituted domains, which could aggregate and therefore only swell and form gel particles but do not dissolve, places higher demands on the statistical distribution of the substituents. The knowledge of regioselectivity, essential for the interpretation of higher structural-level data, can be obtained by various methods, preferentially by CE/UV after hydrolysis. To study the distribution of substituents at the polymer level by mass spectrometric (MS) analysis, partial random depolymerization is required. Due to the ionic character and acid functionality, all the attempts of the direct depolymerization of CMG and further sample preparation suffered from bias, side reactions, and multiple ion formation in MS. Finally, the transformation of CMGs to the corresponding hydroxyethylglucans (HEGs) by the reduction of the esterified carboxy groups with LiAlH4 opened the window for quantitative oligomer MS analysis. While the CM amyloses were reduced quantitatively, the transformation of the CMC was only about 60% but without the formation of mixed CM/HE ethers.