bluuebunny/crossref_metadata_2025 huggingface dataset:
Orthostatic arterial hypotension
Authors:   Universitatea de Medicină și Farmacie „Carol Davila“, București, DIACONU Camelia C. ,   Clinica de Medicină Internă, Spitalul Clinic de Urgenţă „Floreasca“, București, BUCUR Denisa ,   Spitalul Clinic „Colentina“, București, BERCEANU Daniel ,   Clinica de Medicină Internă, Spitalul Clinic de Urgenţă „Floreasca“, București, BRATU Ovidiu Gabriel ,   Universitatea de Medicină și Farmacie „Carol Davila“, București
Published: August 2021

Orthostatic hypotension is a persistent decrease of systolic blood pressure by at least 20 mm Hg and/or diastolic blood pressure by at least 10 mm Hg in the first 3 minutes upon standing. Orthostatic hypotension is more common in the elderly patients, being one of relatively frequent causes of hospitalization in the elderly population. Orthostatic hypotension may be primary or secondary, acute or chronic. Its etiology is represented in most cases by the primary or secondary autonomic failure. Clinical manifestations of orthostatic hypotension occur after the transition from supine to standing, and are due to cerebral hypoperfusion. These consist of nausea, dizziness, generalized weakness, postural instability, fatigue, blurred vision. Cardiological and neurological consult are necessary for diagnosis. Pharmacological treatment of orthostatic hypotension is often unsatisfactory, imposing combination with non-pharmacological measures.
Gestational breast cancer. Surgical treatment, pregnancy and fetal outcome
Authors:   “Fichtelgebirge” Hospital, Marktredwitz, Bavaria, Germany, IONESCU Olivia , BACALBASA Nicolae ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Background. Gestational breast cancer (GBC) is also known as pregnancy-associated breast cancer and it comprises all the breast cancers (BCs) which are diagnosed either during pregnancy or in the first year after delivery or during the lactation period. At present it has been confirmed that the breast malignancies are the most common forms of cancer in pregnant women with a constant increase in its incidence because of the continuous postpone in childbearing especially in women older than 40 years. However, when diagnosed during the pregnancy, the treatment modalities of the BC are complex and difficult to establish as it must be considered the impact of the treatment both on the child and the course of pregnancy. Purpose. Using an online search on Pubmed, our aim was to make a review of the treatment possibilities of a pregnant woman presenting a breast malignant tumor. We have concentrated our paper on the surgical treatment and the possibility of an oncoplastic reconstruction types, the facts of radiotherapy during pregnancy and the prognosis of the GBC particularly in women who opt to continue the pregnancy. A resume of the epidemiology of GBG is also presented. Method. The following key words have been on Pubmed introduced: ,,breast cancer’’, ,,pregnancy’’, ,,staging”, ,,chemotherapy” and ,,radiotherapy”. As mentioned above, we have tried to select the BC cases diagnosed and treated during pregnancy for which the decision of the patient was to continue the pregnancy in spite of the diagnosis. We further aimed to present the prognosis of the pregnancy-associated BC, namely the pregnancy and fetal outcome, and to investigate if the decision to terminate the pregnancy is associated with a survival benefit. Conclusion. The surgical treatment of pregnancy-associated BC does not differ from that of non-pregnancy BC. Axillary LN-dissection is permitted while the data on the safety of sentinel-LN are still poor. Elective termination of the pregnancy has no impact on the overall survival of the patient.
Breast sarcomas. A review of the possible treatment modalities
Authors:   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BACALBASA Nicolae , IONESCU Olivia ,   “Fichtelgebirge” Hospital, Marktredwitz, Bavaria, Germany
Published: August 2021

Background. Breast sarcomas (BS) are rare tumors which origin within the connective tissue of the breast. A clear delimitation from breast carcinoma should be established because the management and evolution and prognosis are different. BS can develop “de novo” – primary BS or can be related to a previously treated malignant breast tumor – for example after breast conservative surgery and adjuvant radiotherapy. Aim. Owing to the rarity of this tumor type, there is limited evidence with regard to the optimal treatment possibilities. The information comes primary from small retrospective studies so that the treatment principles resemble that of primary mesenchymal malignancies arising in other parts of the body (e.g. leiomyosarcoma, angiosarcoma or liposarcoma). We aimed to make a review of the current treatment possibilities of the BS emphasizing on the type and extent of the surgical treatment, the utility of the axillary lymph node (LN) dissection and the feasibility and benefit of an adjuvant chemotherapy. Method. We performed an online research on Pubmed using the following key words: “sarcoma”, “radiotherapy”, “surgery”, “chemotherapy”. We tried to select the data referring to sarcoma developing with the connective tissue of the breast as well as the information of BS developing after irradiation of the breast in women previously diagnosed with breast cancer (BC) who received adjuvant radiotherapy. We further looked for reports about the role of an adjuvant treatment, namely chemotherapy. Conclusion. The only treatment proved to have a benefit on the prognosis is the surgical treatment with the achievement of a wide, radical, complete resection (R0-resection). For angiosarcomas, either primary or therapy-related, the margins of resection should be more than 1 cm for small tumors and more than 3 cm for larger tumors. Adjuvant chemotherapy has limited benefits and should be applied in selected cases.
Allergic rhinitis and pregnancy – management
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, TUDOSE Adriana ,   Clinica Alergologie, Spitalul Clinic „Nicolae Malaxa“, Bucureşti, MATEESCU Radu ,   Spitalul de Obstetrică Ginecologie „Dr. Maria Burghele“, Buftea, MATEI Alexandru ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti,   Spitalul de Obstetrică-Ginecologie, Buftea, ANTOINE Edu ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti,   Spitalul de Obstetrică Ginecologie „Dr. Maria Burghele“, Buftea
Published: August 2021

Allergic rhinitis is a chronic inflammation produced by the action of IgE antibodies which fight against allergens inside the mucosal nazale. It is characterized by symptoms such as nasal obstruction and/or watery rhinorrhea, sneezing and itching. Pregnancy is a temporary testing contraindication. During the pregnancy to detect the allergens involved in the symptoms we advise you to only take in vitro tests. The best approach in the management of rhinitis is to avoid allergens. Patients with mild to moderate rhinitis can only control the symptoms using nasal saline solution administered topically. Antihistamines can be useful during the pregnancy. Immunotherapy has not been found to be teratogenic and is clinically useful in relieving symptoms. The usage of oral decongestans and/or topical is controversial.
Risk Assessment for Complications of Partial Nephrectomy – Comparative Study between Retroperitoneoscopic Approach and Open Surgery
Authors:   Department of Urology, Faculty of Medicine, “Lucian Blaga” University of Sibiu, PIRVUT Valentin , GRIGORE Nicolae ,   Department of Urology, Faculty of Medicine, “Lucian Blaga” University of Sibiu, HASEGAN Adrian ,   Department of Urology, Faculty of Medicine, “Lucian Blaga” University of Sibiu, MIHAI Ionela ,   Department of Urology, Faculty of Medicine, “Lucian Blaga” University of Sibiu
Published: August 2021

Introduction. Partial nephrectomy represent the standard of care for small renal tumor. Laproscopic approach tends to replace open surgery due to similar oncologic results, but with better eastethic outcomes and earlier socio-professional reintegration. Material and methods. Between January 2010 and February 2017, 55 patients (p) underwent partial nephrectomy at our center for clinically localized renal tumor, 21p with LPN by retroperitoneal approach and 34p with OPN. All patients had a normal contralateral kidney. The selection of patients for nephron-sparing surgery was based on preoperative CT scan, location of the tumor, the individual general health status of the patient and individual surgeon preferences. Results. The mean age of patients with partial nephrectomy was 59.6±16.4 years, with 57.9±11.6 years for laparoscopic subgroup and 61.3±12.4 for open surgery. The transfusion rate was 9.52% in LPN group, while in the OPN there was no need for transfusion. The warm ischemia time was higher in the LPN group (21.8±7.2 min) than OPN group (15.7±2.9). The postoperative complication rate is comparable between LPN and OPN (23.81% v.s. 20.58%), but the LPN had higher intraoperative complications. Conclusion. Laparoscopic partial nephrectomy for renal tumors is superior to open surgery by early mobilization of the patient, the low rate of wound complications, short duration of hospitalization, fast socio-professional reintegration of patient, despite the perioperative complication rate that is higher but of low ClavienDindo grade.
Comparative Study of Silicone and Polyurethane Nephrostomy Catheters used for long-term Urinary Drainage in Malignancy
Authors:   Department of Urology, Faculty of Medicine, “Lucian Blaga” University, Sibiu, GRIGORE Nicolae , PIRVUT Valentin ,   Department of Urology, Faculty of Medicine, “Lucian Blaga” University, Sibiu, MIHAI Ionela ,   Department of Urology, Faculty of Medicine, “Lucian Blaga” University, Sibiu, HASEGAN Adrian ,   Department of Urology, Faculty of Medicine, “Lucian Blaga” University, Sibiu
Published: August 2021

Despite the modern advancement in endourology, percutaneous nephrostomy play an important role in many urologic conditions, which of the most important is the relief of upper urinary tract in patients with malignancies that interests the ureter or the uretero-vesical junction. The aim of the study is to compare the complications of polyurethane and silicone catheters used for percutaneous nephrostomy in patients with unilateral or bilateral uretero-hydronephrosis secondary to locally advanced abdomino-pelvin malignancies. We have retrospective analyzed 164 patients (p), admitted between January 2013 and December 2016 in Urology Department Sibiu, who benefit from unilateral or bilateral percutaneous nephrostomy for secondary uretero-hydronephrosis with acute renal failure.
The anti-inflammatory effect of the Ribes nigrum species
Authors:   Catedra Farmacognozie, Fitochimie, Fitoterapie, Facultatea de Farmacie „Titu Maiorescu“, Bucureşti, CORD Daniel , POPESCU Mariana ,   Catedra Farmacognozie, Fitochimie, Fitoterapie, Facultatea de Farmacie „Titu Maiorescu“, Bucureşti, Burghiu HOBEANU Iulia ,   Reţeaua privată de sănătate Regina Maria, Bucureşti, Colette SANDULOVICI Roxana ,   Catedra Farmacognozie, Fitochimie, Fitoterapie, Facultatea de Farmacie „Titu Maiorescu“, Bucureşti, RAICIU Anca Daniela ,   Catedra Farmacognozie, Fitochimie, Fitoterapie, Facultatea de Farmacie „Titu Maiorescu“, Bucureşti
Published: August 2021

Introduction. Blackcurrant (Ribes nigrum L.) is a frequently grown cultivated in different parts of the world with a temperate climate. Fruits have a sour taste and they are rich rich source of vitamin C and rutine, organic acids, pectins, essential oils, as well as micro- and macronutrients. Material and method. Several studies have recently been carried out on several vegetable materials in order to find antioxidant and anti-inflammatory substances for the use of vegetable products in various food products or medicinal preparations as substitutes for synthetic substances. Results and discussions. Ribes nigrum contains a large number of phenolic compounds. The blackcurrant shows a number of health benefits attributed to the anti-inflammatory and antioxidant potential.
Preschool children’s nutrition affects adulthood health
Authors:   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, IGNAT Ancuţa , LUPU Vasile Valeriu ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, STOLERIU Gabriela ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, CIUBARĂ Alexandru Bogdan ,   Universitatea „Dunărea de Jos“, Galaţi, HELLER Marc-Andre ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, CHATZIGIANNI Olympia Evangelia ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, BURLEA Marin ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi
Published: August 2021

The growth and development of children is influenced by multiple factors like genetics, general health, physical activity, sedentary, sleep quality and proper nutrition. The disturbance of these factors during the pre-school period can negatively influence the health of the older child and later of the adult. An essential part of pediatrics is prevention. Pre-school care should provide opportunities for promoting healthy behaviours for appropriate physical and psychosocial development.
Pringle maneuver during open partial nephrectomy for renal tumors
Authors:   Department of Urology, Faculty of Medicine, Lucian Blaga University of Sibiu, HASEGAN Adrian , BRATU Dan ,   Department General Surgery, Faculty of Medicine, Lucian Blaga University of Sibiu, PIRVUT Valentin ,   Department of Urology, Faculty of Medicine, Lucian Blaga University of Sibiu, MIHAI Ionela ,   Department of Urology, Faculty of Medicine, Lucian Blaga University of Sibiu, GRIGORE Nicolae ,   Department of Urology, Faculty of Medicine, Lucian Blaga University of Sibiu
Published: August 2021

Introduction. Sparing kidney tissue is important because studies show that patients who have their entire kidney removed are more likely to suffer from chronic kidney disease after surgery than patients who received a kidney-sparing partial nephrectomy. The aim of study is to show the effectives of Pringle maneuver for clamping renal pedicle in order to minimize warm ischemia during open partial nephrectomy. Material and method. We retrospectively analyzed 34 patients diagnosed with cT1 renal tumors between 2012 and 2016 and underwent open partial nephrectomy in Sibiu Urology Department. During the surgery we perform clamping of renal pedicle with Satinsky clamp or with the Pringle maneuver. We analyzed the flowing parameters: operation time, blood loss, clamping time and serum creatinine before and after the surgery. Results. The mean age of patient with partial nephrectomy was 58.7±14.7 years, with 56.7±12.4 years for Satinsky group and 60.5±11.6 for Pringle group. The average duration for partial nephrectomy was 94.8±19.4 minutes. Average blood loss for all surgeries was 220±30 ml. Conclusion. Pringle maneuver is a safe and effective method with low intra and postoperative complications during open partial nephrectomy, having a good control of the renal pedical with reduced ischemia. Is a feasible method of choice in renal tumour tumor pathology on a single congenital or surgical kidney, mediorenal tumors or near the sinus and multifocal tumors.
Preoperative scoring systems used in retroperitoneoscopic partial nephrectomy for T1-T2 renal tumors
Authors:   Academic Emergency County Hospital, Sibiu, PIRVUT M.V. , GRIGORE N. ,   Academic Emergency County Hospital, Sibiu,   Faculty of Medicine, “Lucian Blaga” University, Sibiu, MIHAI I. ,   Academic Emergency County Hospital, Sibiu, BENCHERKI A. ,   Academic Emergency County Hospital, Sibiu, PRIPOREANU A.T. ,   Fundeni Clinical Institute, National Reference Center for Urinary Genetics and Renal Transplantation, HASEGAN A.G. ,   Academic Emergency County Hospital, Sibiu,   Faculty of Medicine, “Lucian Blaga” University, Sibiu, SABAU D. ,   Academic Emergency County Hospital, Sibiu,   Faculty of Medicine, “Lucian Blaga” University, Sibiu, RACHERIU M. ,   Faculty of Medicine, “Lucian Blaga” University, Sibiu, CRETU D. ,   Faculty of Medicine, “Lucian Blaga” University, Sibiu
Published: August 2021

Introduction. P.A.D.U.A. (The preoperative aspects and dimensions used for anatomic), R.E.N.A.L. (radius exophytic/endophytic nearness anterior/posterior location) and zonal NePhRO scoring were developed in an effort to predict the intraoperative (warm time ischemia, blood loss) and postoperative complications in patients undergoing partial nephrectomy, with an important role on surgical decision-making (2-4). Materials and methods. Between January 2014 and July 2017, 37 patients(p) underwent retroperitoneoscopic nephro-sparing surgery at our center for clinically localized renal tumor. All patients had a normal contralateral kidney. The selection of patients for nephro-sparing surgery was based on preoperative CT scan, location of the tumor, the individual general health status of the patient and individual surgeon preferences. A chart review was carried out, including age, sex, anatomic preoperative scoring system (P.A.D.U.A., R.E.N.A.L. nephrometry and zonal NePhRO), operative time (skin opening to skin closing), estimated blood loss (EBL), warm ischemia time (WIT), hospital stay. Results. The mean age of patients with partial nephrectomy was 54.3±9.1 years. Mean preoperative serum creatinine level for the patient group was 0.97±0.14 mg/dl. All patients had normal contralateral kidney. Average tumor diameter in this group was 3.6± 0.86 cm. When using P.A.D.U.A. score to predict warm time ischemia p value was of 0.001, even if the mean warm ischemia time is higher in medium risk patients than in high risk patients 24.3 min vs. 23.2 min. R.E.N.A.L. nephrometry score was able to predict the warm ischemia time according to the risk groups (17.6 vs. 23.9 vs. 31 min) with a p value under 0.001. Zonal NePhRO score was statistically correlated with total operative time, blood loss, warm ischemia and renal function decrease, all with a p value < 0.05. Conclusion. P.A.D.U.A. score, R.E.N.A.L. nephrometry score and Zonal NePhRO score have proved to be reliable preoperative tools in order to evaluate surgical complexity and to predict outcomes such as warm time ischemia, blood loss, postoperative estimated GFR and complications rate.
A concise assessment of salivary modifications in patients with chronic hepatitis
Authors:   “Carol Davila” University of Medicine and Pharmacy, Bucharest, BADITA Daniela-Gabriela , PIPEREA-SIANU Dan ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, BALCANGIU-STROESCU Andra-Elena ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, CALENIC Bogdan ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, GREABU Maria ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, TANASESCU Maria-Daniela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest,   Department of Nephrology, Emergency University Hospital, Bucharest, RADUCU Laura ,   Discipline of Plastic Surgery and Plastic Reconstructive Microsurgery, Prof. Dr. “Agrippa Ionescu” Emergency Clinical Hospital, Bucharest, STANESCU Iulia-Ioana ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest
Published: August 2021

Background. Saliva is a complex biological fluid that has great potential as a diagnosis fluid for both oral and systemic diseases. At the same time, chronic hepatitis affects millions of people worldwide and can lead to liver cirrhosis and hepatocellular carcinoma. In this context, our research group aimed to evaluate the modifications produced in the saliva of patients with chronic hepatitis compared to healthy subjects. Material and method. The present work included 88 subjects that were divided into 4 groups, each consisting of 22 people. Saliva samples were collected for each participant to the study. Salivary levels of total protein (TP), IgA, IgG and aminotransferases AST (aspartate aminotransferase) and ALT (alanine aminotransferase) were determined. Results. Our results showed significantly increased salivary levels of TP, IgA, AST and ALT for patients with chronic viral hepatitis (CHV) and chronic alcoholic hepatitis (CAH) compared to controls. IgG salivary levels were also higher in patients with hepatitis versus controls, however while statistical significance could be found for patients with chronic hepatitis C (CHC) and CAH, this was not the case for the patients with chronic hepatitis B (CHB). Conclusions. The results of our study showed significantly increased salivary levels of the determined parameters in hepatitis patients compared to the healthy subjects, hence promoting the use of saliva as a diagnosis and monitoring fluid for chronic hepatitis.
Cervical hematoma spontaneously caused by a broken parathyroid cyst
Authors:   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti, GHEMIGIAN Adina , ŢUPEA Claudiu ,   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti, NEAMŢU Corina ,   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti, PAUN Diana ,   Institutul Naţional de Endocrinologie „C.I. Parhon“, Bucureşti, TULIN Adrian ,   Spitalul Clinic de Urgenţă „Prof. Dr. Agrippa Ionescu“, Bucureşti
Published: August 2021

Parathyroid cysts are relatively rare lesions of the neck, usually millimetric in size and without clinical consequences. By contrast, macrocystic forms require additional investigations and often treatment. A cervical hematoma caused by a ruptured parathyroid cyst is extremely rare and usually occurs due to cystic degeneration of an adenoma. We present the case of a male patient with spontaneous cervical hematoma caused by a ruptured parathyroid cyst with rapidly evolving and severe compressive manifestations occurring after an episode of upper respiratory infection. Differential diagnosis is difficult, especially under emergency conditions, and chirugical treatment should not be delayed.
THE DIFFERENCES IN THE APPROACH TO PSORIASIS BASED ON PATIENT AGE
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, STĂNESCU Ana Maria Alexandra , GRĂJDEANU Ioana Veronica ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, APPIAH Ekua Asafoaba ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, BEJAN Gabriel Cristian ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, IANCU Mihaela Adela ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, GIURCĂNEANU Călin ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: August 2021

Psoriasis is no longer an unknown disease; it has been studied extensively worldwide. It can affect people of all ages, making it necessary to differentiate between the childhood and adult forms of the disease. Based on the debut age, one can determine the prognosis, the different immunopathologies, differential diagnosis and treatment, thereby requiring a different approach and special attention in childhood psoriasis. Being a mutilating disease, the quality of life of the children become a big challenge for both the patient and their family. The multidisciplinary team is a necessity because of the possible comorbidities that can occur in the case of children. The family doctor is the first point of contact for the patient, followed by a paediatrician and then a dermatologist.
UTILITY OF INTRAPERITONEAL HYPERTHERMIC CHEMOTHERAPY IN PERITONEAL CANCER FROM ENDOMETRIAL CANCER – LITERATURE REVIEW
Authors:   Department of Obstetrics and Gynecology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, BACALBASA Nicolae , BALESCU Irina ,   Department of General Surgery, Ponderas Academic Hospital, Bucharest
Published: August 2021

Once the benefits of intraperitoneal heated chemotherapy has been widely reported in patients presenting colorectal, appendicular or even ovarian malignancies, this method has been proposed as a therapeutic strategy in treating peritoneal carcinomatosis with various origins such as gastric cancer, breast cancer or even endometrial cancer. Although most often patients presenting endometrial cancer are diagnosed in an early stage of the disease and are submitted to surgery with curative intent, in certain cases the diagnostic is established only later in the evolution of the disease, when disseminated peritoneal lesions are present. In all these cases an aggressive surgical approach consisting to debulking surgery to no residual disease seems the best therapeutic option in order to achieve a good control of the disease. Moreover, it has been stipulated that association of intraperitoneal heated chemotherapy might improve the long term outcomes of such patients. This is a literature review regarding the utility of intraperitoneal heated chemotherapy in treating peritoneal carcinomatosis with endometrial origin.
ACNE FULMINANS – MEDICAL EMERGENCY IN THE PRACTICE OF THE FAMILY DOCTOR
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, STĂNESCU Ana Maria Alexandra , GRĂJDEANU Ioana Veronica ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, GOANŢĂ Ana Maria ,   Facultatea de Medicină Veterinară, Bucureşti, GIURCĂNEANU Călin ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: August 2021

Acne is a common affection in the family doctor's office, usually treating light acne forms. It is very important to detect acne fulminans as soon as possible. This is a rare but very destructive form, with systemic implications, requiring immediate specialist treatment, usually requiring hospitalization.
Modern antimicrobial therapy in dental caries
Authors:   Disciplina Odontoterapie Restauratoare, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Gheorghiu Irina-Maria , Perlea Paula ,   Disciplina Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Iliescu Alexandru Andrei ,   Disciplina de Reabilitare Orală Complexă, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie Craiova, Scărlătescu Sânziana ,   Disciplina Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Suciu Ioana ,   Disciplina Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Temelcea Anca ,   Disciplina Tehnică Dentară, Facultatea de Moaşe şi Asistenţă Medicală
Published: August 2021

This article reviews the current therapeutic attitude on dental caries prevention involving antimicrobial strategies, based on the modern definition of dental caries as a microbial disease. The most important and used prophylactic measures are: topical and systemic administration of fluorinated products, diet control and maintenance of a rigorous dental oral hygiene.
Clinical aspects of Angle class II/1 malocclusion during the eruption of the 12-year-old molar
Authors:   Disciplina de Ortodonţie, Universitatea de Medicină şi Farmacie, Craiova, Dascălu Ionela Teodora , Bunget Adina Magdalena ,   Disciplina de Prevenţie Orodentară, Universitatea de Medicină şi Farmacie, Craiova, Coleş Evantia ,   Disciplina de Tehnologie a Protezelor Dentare, Universitatea de Medicină şi Farmacie, Craiova, Mărăşescu P. ,   Disciplina de Tehnologie a Protezelor Dentare, Universitatea de Medicină şi Farmacie, Craiova, Mărăşescu Felicia ,   Disciplina de Ortodonţie, Universitatea de Medicină şi Farmacie, Craiova, Amărăscu Marina ,   Disciplina de Morfologie şi Semiologie a Sistemului Stomatognat, Universitatea de Medicină şi Farmacie, Craiova, Nicola Andreea Gabriela ,   Disciplina de Prevenţie Orodentară, Universitatea de Medicină şi Farmacie, Craiova, Stan Mihaela ,   Disciplina de Materiale Dentare, Universitatea de Medicină şi Farmacie, Craiova, Moraru Iren ,   Disciplina de Endodonţie, Universitatea de Medicină şi Farmacie, Craiova, Dăguci C. ,   Disciplina de Sănătate Orală, Universitatea de Medicină şi Farmacie, Craiova, Funieru Cristian ,   Disciplina de Prevenţie Orodentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Bechir Edwin Sever ,   Disciplina de Parodontologie, Universitatea de Medicină şi Farmacie, Tg. Mureş
Published: August 2021

Introductions. The vicious habit of sucking the thumb is an etiological factor of Angle Class II/1 malocclusion. Case presentation. In the clinical case that we intend to present, the main goal of the treatment was to recover the occlusion and the functions of the dento-maxillary complex. The treatment relied on the use of a fixed appliance. The sagittal inocclusion was thus reduced and the parameters of occlusion were brought to normality. Conclusions. We consider that the period of orthodontic treatment was reduced because the climax of the bones growth took place at the same time with the eruption of the 12-year-old molars.
Putative involvement of endodontic treatments in maxillary sinus aspergillosis
Authors:   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Perlea Paula , Temelcea Anca ,   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie, Craiova, Iliescu Alexandru Andrei ,   FMAM Tehnică Dentară, Bucureşti
Published: August 2021

The host immune system is not so active against Aspergillum sp. due to the anatomical location of maxillary antrum that facilitates the fungal multiplication. At least 10% of chronic sinusitis are actually infections with Aspergillum, mainly developing the clinical feature of maxillary aspergilloma. Though the terminal respiratory airways are the main access portal of the mycotic infection, the oro-antral fistulas, dental extractions, iatrogenic root perforations which also involve the mucousa of the alveolar ridge might be additional risk factors. It seems that the root canal overfillings may develop a maxillary sinus aspergillosis since zinc from the in sinusal cavity extruded sealers plays the role of a growth factor for Aspergillus. Accordingly, a chronic sinusitis with purulent secretions, refractory to conventional treatment and associated with a foreign body identified on radiographs as root filling material might be suspected as maxillary sinus aspergilossis.
Clinical and therapeutical aspects of dental impaction
Authors:   Departamentul de Medicină Dentară, Facultatea de Medicină şi Farmacie, Universitatea „Dunărea de Jos“, Galaţi, Decusară Mioara , Şincar Cerasella Dorina ,   Departamentul de Medicină Dentară, Facultatea de Medicină şi Farmacie, Universitatea „Dunărea de Jos“, Galaţi, Popa Gabriel Valeriu ,   Departamentul de Medicină Dentară, Facultatea de Medicină şi Farmacie, Universitatea „Dunărea de Jos“, Galaţi
Published: August 2021

Introduction. Dental impaction represents the group of isolated dental anomalies characterized by retention of a tooth with a fully formed root in the jaw bone, after the eruption period has passed. This anomaly may affect deciduous teeth, permanent or supernumerary teeth causing aesthetic and / or functional disorders. Case report. The case presents a clinical situation of a girl who presented two maxillary teeth impacted (a central incisor and a cuspid) who underwent surgical exposure and orthodontic treatment for their arch alignments. Conclusions. Impacted teeth may produce dental malpositions or root resorption of the adjacent teeth, cysts or chronic local infections, which carry out a surgical orthodontic treatment, complex and for a long term, depending on the clinical situation existing.
Influence of local factors on methods of orthodontic treatment in patients with external radicular resorption
Authors:   Disciplina de Tehnică Dentară, Facultatea de Moaşe şi Asistenţă Medicală, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Temelcea Anca Nicoleta , Perlea Paula ,   Disciplina de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Gheorghiu Irina Maria ,   Disciplina de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Iliescu Alexandru Andrei ,   Disciplina de Reabilitare Orală, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie, Craiova
Published: August 2021

Orthodontic treatment should solve dental-maxillofacial disorders respecting as far as possible the conservative biological principles of the dental substance. Dosage of orthodontic forces must be made according to the intended therapeutic objective, but without jeopardizing the dental implantation or aggravating the root injury, if it is already installed. The prognosis of evolution in these cases is reserved and limited by the possibilities of repairing the root injuries.
Comparative evaluation of root canal preparation using Wave One and Reciproc Systems
Authors:   Disciplina de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Scărlătescu Sinziana Adina , Perlea Paula ,   Disciplina de Endodonţie, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Gheorghiu Irina Maria ,   Disciplina de Odontoterapie Restauratoare, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Rolea Cătălin Nicolae ,   Practica privată
Published: August 2021

Aim. The aim of this study was to assess the preparation of root canals using single-file instruments Wave One (Densplay-Sirona) and Reciproc (VDW Gmbh). Materials and methods. Forty lower mesial and distal root canals were divided into 4 groups (n=10) according to shaping technique; mesial roots were prepared using Reciproc 25 and WaveOne Primay and distal root using Reciproc 40 and Wave One Large respectively. Pre- and post-instrumented radiographs were taken to examine and compare the cross-sectional shape of the canals at 3, 6 and 9 mm. Results. Wave One led to bigger diameters especially at 9 mm, the difference being of 0,22 mm versus Reciproc 25 and 0,14 mm versus Reciproc 40. Conclusions. The Wave One system produced a bigger tapered root canal preparation versus the Reciproc system.
Influence of premature loss of the first permanent molar on the dental arches morphology – radiological evaluation
Authors:   Disciplina Reabilitare Orală, Sănătate şi Management, Universitatea de Medicină şi Farmacie „Iuliu Haţieganu“, Cluj-Napoca, Pop Andreea , Câmpian Radu Septimiu ,   Disciplina Reabilitare Orală, Sănătate şi Management, Universitatea de Medicină şi Farmacie „Iuliu Haţieganu“, Cluj-Napoca, Păcurar Mariana ,   Disciplina Ortodonţie, Universitatea de Medicină şi Farmacie, Târgu-Mureş, Ionescu Ecaterina ,   Disciplina Ortodonţie, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Teodorescu Elina ,   Disciplina Protetică Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Milicescu Ştefan ,   Disciplina Protetică Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Jiman Paula ,   Universitatea de Medicină şi Farmacie „Iuliu Haţieganu“, Cluj-Napoca, Bunta Olimpia ,   Disciplina Ortodonţie, Universitatea de Medicină şi Farmacie „Iuliu Haţieganu“, Cluj-Napoca, Ţărmure Viorica ,   Disciplina Ortodonţie, Universitatea de Medicină şi Farmacie „Iuliu Haţieganu“, Cluj-Napoca
Published: August 2021

Objectives. The purpose of this research was to radiological identify the morphological changes of the dental arcades resulting from the premature loss of the permanent first molars. Material and method. The study was conducted between 2014-2016 on a group of 50 patients aged 12-15 years who presented themselves with the imminence of premature loss of the first permanent molars. 1: 1 panoramic radiographs were performed before the extractions and at 6 and 12 months after the extractions respectively. Results and discussions. The changes in position of the antagonist teeth and those of the second permanent molars, in the two dental arches, both in the sagittal and in the vertical plane were revealed. Conclusions. The premature loss of the first permanent molars, especially after the eruption of the second permanent molars, causes unwanted dental movements and severe dental-maxillary abnormalities over time.
The correlation between facial esthetics and social psychology from orthodontic perspective
Authors:   Disciplina de Ortodonţie şi Ortopedie Dento-facială, Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Enache Aurelia Magdalena
Published: August 2021

It is known that there is a strong correlation between orthodontics and social psychology. The effect of the orthodontic treatment on facial esthetics has an important impact on attractiveness and personality of the patient. This correlation should be taken into consideration in all the phases of the orthodontic treatment: patient exam and problem list, treatment planning and type of orthodontic appliance, assessment of the orthodontic treatment. The evaluation of the orthodontic treatment results is different for the doctor and the patient and has led to a change of the paradigm, that of the soft tissues, which puts aesthetic and functional positions equally for the establishment of the treatment plan and for its evaluation.
FUNCTIONAL DYSPEPSIA (PART II)
Authors:   Medicină Internă I, Spitalul Universitar de Urgenţă, Bucureşti, Olteanu Dan , Şchiopu Oana ,   Medicină Internă I, Spitalul Universitar de Urgenţă, Bucureşti
Published: August 2021

The present pathophysiological features and therapeutic methods are presented. A treatment and diagnostic algorithm is offered. New therapies in refractory functional dyspepsia are presented.
BARTHOLIN’S GLAND CARCINOMA
Authors:   “Prof. Dr. Agrippa Ionescu“ Clinical Emergency Hospital, Bucharest, Lintoiu Beatrice , Bacalbasa Nicolae ,   “Carol Davila“ University of Medicine and Pharmacy, Bucharest
Published: August 2021

Accounting for less than 5% of all vulvar malignancies, primary carcinoma of the Bartholin gland is a rare pathology. Adenocarcinomas or squamous cell carcinomas are the most common histologic types. Diagnosis is made in many symptomatic cases after resection of what was thought to be a Bartholin’s cyst or abcess. Surgical options, depending of the extension of the disease, include radical local excision, radical hemivulvectomy and radical vulvectomy with or without inguinofemoral and pelvic lymphodissection. Adjuvant radiotherapy, in selected cases, may decrease the rate of recurrence.
EARLY PREDICTION OF PREECLAMPSIA ÎN PREGNANCY
Authors:   Spital Clinic „Filantropia“, Bucureşti, Iordache Oana Mihaela , Neştianu Liliana ,   Spital Clinic „Filantropia“, Bucureşti, Neştianu George Erick ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: August 2021

Preeclampsia is a major health problem because it determines higher incidence in maternal and perinatal morbidity. Early prediction of preeclampsia in pregnancy can improve both the maternal and perinatal outcome by ensuring appropriate management. There are multiple algorithms using maternal risk factors, biophysical markers, biochemical markers and they try to predict preeclampsia. Low doses of aspirin can improve the prognostic of preeclampsia.
PORTACAVAL FIBROUS CONNECTIONS: LITTLE KNOWN ANATOMICAL STRUCTURES OF LIVER
Authors:   Tbilisi State Medical University, Georgia, Chanukvadze Ilia
Published: August 2021

Background & Aims. Studies dealing with the architecture of the portal and caval canals of liver have overlooked the probability of the fibrous connections between the major portal complexes and hepatic veins when they touch each other. Such a probability is essential for both theoretical and practical medicine. Methods. We studied macro- and micro-morphological specimens from 104 normal adult and 18 normal embryonic and fetal livers. Results. We found that the fibrous sheathes of the portal complexes and hepatic veins fuse in certain areas where these structures cross each other. This anatomical relationship between the portal tracts and hepatic veins is a normal occurrence in human liver and originates at 11th-12th week of embryogenesis. Conclusions. The paper is an effort to demonstrate anatomical and clinical significance and embryogenesis of the portacaval fibrous connections.
THE EFFECT OF CREATIVE PROBLEM SOLVING WITH THE INTERVENTION SOCIAL SKILLS ON THE PERFORMANCE OF CREATIVE TASKS
Authors: Suryanto Hadi , Degeng I Nyoman Sudana , Djatmika Ery Tri , Kuswandi Dedi
Published: August 2021

This research aims to determine the social skills intervention with the student’s ability to solve problems creatively towards understanding the concepts and procedures: the objectives of learning. A quasi-experimental research design was used to see the interaction between attitudes and treatments. The research sample was students who took computer courses in reality-based laboratories in vocational schools. Data analysis was performed using descriptive analysis techniques and inferential statistical multivariate analysis of variance two paths. Creative problem solving is intervened by a background in social skills to understand concepts and procedures. Social skills have a greater influence on the creative process. This can be seen when giving creative problem-solving tasks. The abilities they have, about; readiness to learn, the ability to understand one’s own needs, and the ability to understand one’s own learning style, greatly support the performance of their creative assignments. At the same time, external factors have less influence on the performance of creative tasks. These external factors are influenced by the class social environment, group formation, and class management. Students who have high social skills find it easier to complete creative tasks, and students who have low social skills have problems adapting and adjusting to the learning process
HOW DOES THE G20 SUMMIT AFFECT LAND MARKET? EVIDENCE FROM CHINA
Authors: Du Xuejun , Huang Zhonghua
Published: August 2021

We employ the difference-in-difference and synthetic control methods to investigate the capitalization effect of hosting the G20 Summit on land market, based on China’s land transaction dataset from 2011 to 2019. We find that hosting the G20 Summit has a significant positive effect on land prices in the host city, increasing land prices by over 22.6% compared to comparable cities. The impact of hosting the G20 Summit on land prices is larger in the post-G20 period than in the preparation period. Further, hosting the G20 Summit has heterogeneous and distributional effects on land prices. The capitalization effects of venue construction and transportation infrastructure upgrading on land prices are the main channels.
The Competing Effect of Gas and Stars in the Evolution of Massive Black Hole Binaries
Authors: Bortolas Elisa , Franchini Alessia , Bonetti Matteo , Sesana Alberto
Published: August 2021

Massive black hole binaries are predicted to form during the hierarchical assembly of cosmic structures and will represent the loudest sources of low-frequency gravitational waves (GWs) detectable by present and forthcoming GW experiments. Before entering the GW-driven regime, their evolution is driven by the interaction with the surrounding stars and gas. While stellar interactions are found to always shrink the binary, recent studies predict the possibility of binary outspiral mediated by the presence of a gaseous disk, which could endlessly delay the coalescence and impact the merger rates of massive binaries. Here we implement a semianalytical treatment that follows the binary evolution under the combined effect of stars and gas. We find that binaries may outspiral only if they accrete near or above their Eddington limit and only until their separation reaches the gaseous disk self-gravitating radius. Even in case of an outspiral, the binary eventually reaches a large enough mass for GW to take over and drive it to coalescence. The combined action of stellar hardening, mass growth, and GW-driven inspiral brings binaries to coalescence in a few hundreds of megayears at most, implying that gas-driven expansion will not severely affect the detection prospects of upcoming GW facilities.
Morphometric variation in wolves and golden jackal in India (Mammalia, Carnivora)
Authors: Srinivas Yellapu , Jhala Yadvendradev
Published: August 2021

Species of Canis (Carnivora, Canidae) have similar morphology and distinguishing sympatric species is challenging. We present data on morphometry of skull, body and hair of three wild Canis species that occur in India, which include two wolves (Indian wolf, Canis lupus pallipes; and Himalayan wolf, Canis himalayensis) and the golden jackal (Canis aureus). A total of 20 cranial and six body measurements and microscopic characteristics of guard hair were analysed, using multivariate ordination to differentiate between species. Cranial measures of the Himalayan wolves were found to be the largest followed by Indian wolves and golden jackals. However, many measures overlapped amongst the three species. Two Principal Components each, for body measures and cranial measures, explained 86 and 91% of the variation in the data, respectively. These Components discriminated the two wolves from golden jackals, but could not distinguish between wolves. Hair medullary patterns were simple and wide type, whereas hair cuticular patterns showed crenate scale margins, near scale distance and irregular wavey scale patterns for all Canis taxa and were not useful to distinguish species. Data reported in this study further contribute to the existing global data on wild canids for a holistic understanding of the variation within the genus and show that distinguishing between all sympatric species from morphology alone may not be possible.
Antitumor activity of the combination of artemisinin and epirubicin in human leukemia cells
Authors: Zhelyazkova Margarita Y. , Hristova-Avakumova Nadya G. , Momekov Georgi Tsv.
Published: August 2021

Aim: We evaluated the tumor-inhibiting effect of artemisinin applied separately and in combination with epirubicin on leukemia HL-60 and HL-60/Dox cell lines, its dose modulation effect and its potency to  influence iron-induced oxidative damage of biologically relevant molecules.

Materials and methods: MTT assay and the method of Chou-Talalay were used to show the inhibition of tumor cell proliferation and to evaluate the synergistic effect and modulation effect of artemisinin and epirubicin at varying concentrations. We also used spectrophotometric assays to determine the potency of artemisinin to influence iron-induced molecular degradation of lecithin and deoxyribose.

Results: Artemisinin exhibits tumor-inhibiting effect on both the anthracycline-sensitive and anthracycline-resistant promyelocytic cell lines, reaching 88% and 61% (T/C), respectively, when applied at higher concentrations in a dose-dependent manner. The combination of artemisinin and epirubicin shows synergistic effects in all tested concentrations on doxorubicin-resistant cells (CI<0.7). Artemisinin sensitizes the resistant cells towards epirubicin as shown by the CI (combination index) values and has a dose-modulation effect as shown by DRI (dose reduction index). Artemisinin induces deoxyribose oxidative degradation when applied alone and exerts synergistic deoxyribose degradation effect when applied with iron. However, artemisinin does not influence the studied processes in the lecithin-containing model system and has no potential to induce lipid peroxidation.

Conclusions: This study presents a new opportunity to enhance the effectiveness of epirubicin-based treatment regimens with addition of artemisinins for resistant tumors.