bluuebunny/crossref_metadata_2025 huggingface dataset:
Role Models of The Early Christians’ Life (Acts 2:41-47) for Pastoral Lingkungan in The Archdiocese of Semarang
Authors: Relliantoko Aditya - , Prasetya Feremenatos Oktafilio Adi , Aryanto Antonius Galih Arga Wiwin
Published: January 2025

In the context of pastoral care, the Church of the Archdiocese of Semarang has created a policy of establishing small base groups among the community. Each parish in the Semarang Archdiocese is subdivided into sub-groups, which are then referred to as kring or lingkungan. The existence of ‘lingkungan’ certainly cannot be separated from the pastoral initiative of the missionaries at the beginning of the mission Church in Java Island. The missionaries, who were very limited in terms of numbers and services, were greatly helped by the presence of Catholic teachers who were present in remote villages and involved in preaching the Gospel for the community. In this study, the authors attempt to see the relevance of the life of the local Church community and the ideal of the Early Church as depicted in Acts 2:41-47. The situation of the early community lived in a basic group that was diligent in prayer and togetherness, was seen as an ideal model to be achieved through Church life in an based group of ‘lingkungan’.
Management of Alternaria leaf blight (Alternaria polianthi) of tuberose (Agave amica)
Authors: Sonavane Priti , T Usha Bharathi
Published: January 2025

Tuberose (Agave amica) is a perennial bulbous crop widely cultivated across the globe for its attractive and sweetly scented flowers used for loose flower, cut flower, perfume manufacture, essential oil production, and decoration. Alternaria leaf blight disease caused by Alternaria polianthi is a major limitation in tuberose cultivation. A field experiment was formulated to evaluate six fungicides against Alternaria polianthi causing leaf blight in tuberose. Results indicated that Difenconazole 25EC was the most effective with disease severity (11.13) compared to other treatments, followed by Tebuconazole 2DS. Tebuconazole 2DS and Azoxystrobin 23SC were the most effective in increasing the number of flowers per spike and spike length. Difenconazole 25EC also showed high effectiveness, particularly in spike length.
Geoelectric, geomagnetic and vertical gradient investigation on Knossos area, Crete Island for detection of archaeological settlements
Authors: Stephanopoulos Panos , Papamarinopoulos Stavros
Published: January 2025

A Detailed geophysical investigation was conducted on Knossos territory of Crete Island. Main scope was the detection of underground archaeological settlements. Geophysical prospecting applied by an experienced geophysical team. According to area dimensions in relation to geological and structural conditions, the team designed specific geophysical techniques, by adopted non-catastrophic methods. Three different types of geophysical techniques performed gradually. Geophysical investigation consisted of the application of geoelectric mapping and geomagnetic prospecting. Electric mapping focusses on recording soil resistance distribution. Geomagnetic survey was performed by using two different types of magnetometers. Firstly, recorded distribution of geomagnetic intensity and secondly alteration of vertical gradient. Measured stations laid along the south-north axis with intervals equal to one meter. Both magnetometers were adjusted on a quiet magnetic station. Values were stored in files readable by geophysical interpretation software in XYZ format. Oasis Montaj was adopted for interpretation of measured physical properties distribution. Interpretation results were illustrated as color scale maps. Further processing applied on magnetic measurements. Results are confirmed by overlaying results from three different techniques. Geoelectric mapping contributed to detection of a few archaeological targets. Most of them were recorded by geomagnetic technique. Total intensity aimed to report the existence of magnetized bodies. Vertical gradient detected subsurface targets with clearly geometrical characteristics.
The role of regional government in the development of MSMEs in Cirebon City
Authors: Daiman Iing , Karlina Nina , Nurasa Heru , Sukarno Dedi
Published: January 2025

In order to support MSME players, the government continues to provide stimulus to accelerate the national economic recovery process and strengthen Bank Indonesia’s policy mix related to strengthening financing or credit. Several things have been done in the context of developing MSMEs in the agricultural sector through the development of end-to-end integrated agricultural clusters by utilizing digitalization for superior commodities, volatile foods and export commodities. The development of this agricultural cluster also supports the inflation control program in West Java. Cirebon City, is one of the cities/regencies in West Java which has the target of “Increasing the role of industry, trade, cooperatives and MSMEs in the economic stability of Cirebon City” as reflected in the average achievement of the two performance indicators as measuring tools, namely 98.58%. Therefore, this research aims to describe the role of local government in developing MSMEs in Cirebon City. The research results show that the regional government plays a role as a facilitator which is realized through training activities, capital and technology assistance, the regional government also plays a role as a catalyst which is realized through promotional activities for MSME products in Cirebon City.
Antibacterial activity improvement in a point mutant K45E of the pepper defensin J1-1
Authors: Muñoz-Pérez Gilberto Andrés , Guillén-Chable Francisco A. , Corzo Gerardo , Arenas-Sosa Ivan , Sánchez-Cach Lucila A. , Estrada Georgina
Published: January 2025

Plant defensins have attracted much attention in the development of new antimicrobials. Yet the elucidation of their modes of action against bacterial pathogens is still incipient. The available recombinant systems to obtain plant defensin mutants with enhanced or optimized antibacterial activity may help to accelerate the knowledge of their action mechanisms and their applications against pathogens. In this work, the point mutant defensin K45E (J1-1_K45E) was obtained by the same recombinant system as J1-1 defensin. The characterized peptide conserved antibacterial activity against the gram-negative Pseudomonas aeruginosa and showed a dose improvement relative to J1-1. Furthermore, the mutant J1-1_K45E exhibited a gain in function against the gram-positive Staphylococcus aureus. Finally, to correlate structural changes and antibacterial activity, two properties involved in defensins’ modes of action were measured. First, the mutant J1-1_K45E which oligomerizes in a distinct pattern was compared with J1-1 and secondly, J1-1_K45E shows a distinct lipid binding profile because it binds preferentially to phosphatidylserine. Together, our findings support the idea that amino acid sequence variability in plant defensins superfamily can generate major functional changes, and highlight the relevant role of charged residues, beyond the g-core loop, in the improvement of J1-1 antibacterial activity.
The influence of Hermetia illucens L. frass on the health, stress, and development of barley
Authors: Grzanka Monika , Sobiech Łukasz , Radzikowska-Kujawska Dominika , Sawinska Zuzanna , Kowalczewski Przemysław Łukasz , Świtek Stanisław , Skrzypczak Grzegorz , Kardasz Przemysław
Published: January 2025

Barley cultivation faces challenges from changing climate conditions, including the increasing threat of drought. This study explored the potential of a fertilizer derived from Hermetia illucens L. frass to enhance the development and health of spring barley under optimal and drought conditions. The experiment, conducted in a controlled greenhouse environment, employed various fertilization treatments, including cattle manure and two doses of H. illucens L. frass-based fertilizer. Comprehensive assessments were made through visual observations and physiological measurements, including chlorophyll fluorescence, leaf gas exchange, and CO2 exchange between the soil and the atmosphere. The results demonstrated that the application of H. illucens L. frass-based fertilizer significantly improved barley vigor and health compared to the control and cattle manure treatments, especially under drought stress. Physiological measurements revealed positive effects on chlorophyll fluorescence parameters, indicating enhanced photosynthetic efficiency. Leaf gas exchange parameters also reflected improved photosynthetic activity, with the H. illucens L. frass-treated plants outperforming others. This study provides valuable insights into the potential of insect-derived fertilizers, particularly H. illucens L. frass, as a sustainable and effective way to enhance crop resilience to drought. As climate change continues to pose challenges to agriculture, incorporating such novel fertilizers may offer a promising avenue for sustainable crop production.
The protective effect of trehalose and monosodium glutamate on yeast viability and antagonistic properties during freeze-drying
Authors: Krzymińska Joanna , Kowalska Jolanta
Published: January 2025

In the present eco-conscious era, consumers opt for food choices reflecting ethical and environmental concerns, which increases the demand for organic products. Biocontrol is a viable plant protection method in organic farming. Freeze-drying is a long-term preservation technique for microbial agents, ensuring their genetic stability and viability. To reduce freeze-drying-induced damage to their cells, cryoprotective agents like trehalose and monosodium glutamate are used. This study evaluated the impact of the addition of these substances during the freeze-drying process on chosen yeast isolates’ viability, their ability to survive on tomato leaves and maintain antagonistic properties against Botrytis cinerea Pers. Yeast isolates 114/73 (Wickerhamomyces anomalus E.C. Hansen) and 117/10 (Naganishia albidosimilis Vishniac & Kurtzman) were tested on tomato plants under greenhouse conditions before and after the freeze-drying process for both the ability to colonize leaves and as a preventive and interventional treatment against B. cinerea. Yeast viability post freeze-drying was evaluated in vitro. Both trehalose and monosodium glutamate increased yeast viability during the freeze-drying process. Viability was not very high (from 30.33 to 36.17% for 117/10 and from 10.67 to 16.5% for 114/73). Yeast dehydrated after freeze-drying, protected with trehalose and monosodium glutamate, displayed the same colony count on tomato leaves as before freeze-drying. The efficacy of protective treatments depended on the yeast isolate, the protective substance used during freeze-drying, treatment timing (prevention vs. intervention), and interactions of those factors. Cryopreserved isolate 117/10 performed better than 114/73 with the addition of either trehalose or monosodium glutamate, reducing the disease severity index from 88.3% (control) to 18.75−55.33%. Preventive treatments were more efficient than intervention. The leaf colonization ability and biocontrol efficacy of yeast isolates against B. cinerea post-freeze-drying offer promising solutions in sustainable agriculture. However, further research, to analyze the interactions between various factors and to optimize strategies may be needed.
Impact of tillage and no-tillage cultivation on the occurrence of entomopathogenic fungi in soil with integrated plant protection
Authors: Kierzek Roman , Sosnowska Danuta , Pruciak-Nowak Agata
Published: January 2025

This study aimed to evaluate the impact of tillage and no-tillage cultivation on entomopathogenic fungi in the soil. The research was carried out in 2021‒2022 on plots at the Field Experimental Station of the Institute of Plant Protection – National Research Institute in Winna Góra, Poland. Winter oilseed rape, pea and winter wheat were grown on the plots. Entomopathogenic fungi were isolated using the trapping insect method and their occurrence intensity was assessed. The results demonstrated a positive effect of no-tillage cultivation on the presence of entomopathogenic fungi in the soil. In May 2021, the greatest numbers of trapped insect larvae infected by fungi were in the pea plots (90%) with no-tillage systems, while with tillage it was 43% lower. In June 2022, the greatest number of larvae infected by fungi were in the pea plots (96.7%) with no-tillage systems, while with tillage it was 23% lower. Among the isolated entomopathogenic fungi, the dominant genus was Cordyceps in all cultivation technologies.
Impact of UV-C irradiation on storage pests with different ecological functions and the viability of the treated grains
Authors: Keszthelyi Sándor , Gibicsar Szilvia , Binder Antal , Somfalvi-Tóth Katalin , Pál-Fám Ferenc
Published: January 2025

This study was carried out to investigate the effect of different exposures of UV-C radiation (253.2 nm) (5, 10, 15, 20 and 25 mins) on the mortality of adult stages of four stored product pests: Sitophilus granarius L. (Coleoptera: Curculionidae) as a primary pest, Tribolium castaneum (Herbst) (Col.: Tenebrionidae), Cryptolestes ferrugineus (Stephens) (Col.: Laemophloeidae) and Oryzaephilus surinamensis (Ganglbauer) (Col.: Silvanidae) as secondary pests. Additionally, the viability of treated maize and wheat grains influenced by UV-C radiation (10 mins of UV-C at a distance of 22 cm) was analyzed by using a tetrazolium test. Insect rearing was carried out at 26 ± 2°C, 60 ± 7% RH, 16/8 photoperiod. Our results confirmed that a longer exposure (25 min.) to UV-C corresponded with higher mortality over time. In the elapsed time after radiation treatment as a function of exposure, the mortality was characterized by a power trend line for each examined insect species. S. granarius, as the primary stored product pest, in the crop treated by shorter exposure may prevent subsequent infestation of secondary stored product pests (T. castaneum, C. ferrugineus, O. surinamensis). The tetrazolium test showed that wheat seeds were more sensitive to UV-C radiation than maize seeds. This pest elimination technique is primarily recommended in environments exempted from viable stored seeds. UV-C irradiation of stored products could be an effective non-chemical practice against arthropod pests that move on the surface.
The distribution of pigeon adenoviruses in Northern Chinese pigeon and turtledove flocks provides further evidence of viral crosstransmission
Authors: Li Yi , Xiang Chen , Xing Yanan , Jing Shengfan , He Hongxuan
Published: January 2025

OBJECTIVE

To understand the prevalence, genetic diversity, and potential pathogenicity of adenoviruses present in pigeon and turtledove populations.

METHODS

Nested PCR and Sanger sequencing methods were used to identify the genotype and percentage of various adenoviruses in the feces of pigeon (Columba) and turtledove (Streptopelia) populations. In Beijing, China, a total of 194 fresh feces samples from meat-use pigeons (C livia domestica), homing pigeons (C livia domestica), wild pigeons (C livia domestica), and turtledoves (S decaocto and S chinensis) were collected using noninvasive sampling collection techniques. Their partial DNA-dependent DNA polymerase gene sequences were obtained using nested PCR and double-ended Sanger sequencing, and their genotypes were then ascertained based on sequence alignment.

RESULTS

A total of 6 genotypes of adenovirus were detected in pigeon and turtledove flocks, including pigeon adenovirus (PiAdV)-1, PiAdV-2A, PiAdV-3, PiAdV-4, PiAdV-5, and a novel adenovirus genotype (PiAdV-6). Among them, PiAdV-1 was found widespread in flocks of pigeons exhibiting extensive presentations of hepatic necrosis. Highly conserved PiAdV-4 and PiAdV-5 were found to be nonpathogenic and extensively distributed in all pigeon and turtledove groups.

CONCLUSIONS

These findings imply the presence of diverse PiAdVs in pigeon and turtledove flocks, and the wild pigeons and wild turtledove birds are potentially serving as natural sources of these viruses.

CLINICAL RELEVANCE

This study provides supportive evidence of the pathogenicity of different genotypes of adenovirus in pigeon flocks and also implies that stopping the transmission of the virus brought by wild pigeons and turtledoves may be important for the prevention of diseases associated with PiAdVs.
Machine learning models provide modest accuracy in predicting clinical impact of porcine reproductive and respiratory syndrome type 2 in Canadian sow herds
Authors: Melmer Dylan John , O’Sullivan Terri L. , Greer Amy , Ojkic Davor , Friendship Robert , Poljak Zvonimir
Published: January 2025

Objective

To determine the predictive potential of the open reading frame 5 nucleotide sequence of porcine reproductive and respiratory syndrome (PRRS) virus and the basic demographic data on the severity of the impact on selected production parameters during clinical PRRS outbreaks in Ontario sow herds.

Methods

A retrospective longitudinal study of clinical outbreaks in Ontario sow herds at various points between September 5, 2009, and February 5, 2019, was conducted using herds as units of analysis. Data were gathered from study sow farms in Ontario at the start of each clinical outbreak. Six machine learning models and 2 different genetic input structures of open reading frame 5 sequences were utilized to predict the impact on abortion and preweaning mortality.

Results

Extreme boosting machine learning models with genetic data represented through 2-dimensional multiple correspondence analysis had the highest accuracy when predicting clinical outcomes (60.8% [SD = 12.4%] and 74.4% [SD = 13.2%]) for abortion and preweaning mortality outcomes, respectively. The mean sensitivity of classifying outbreaks with a high impact on abortion was 50%, with a specificity of 89.2%. The mean sensitivity of classifying outbreaks with high preweaning mortality was 56.2%, with a specificity of 85.2%.

Conclusions

The data and methods utilized herein exhibited improvement in accuracy over the baseline; however, this increase was not sufficient to warrant field implementation.

Clinical Relevance

Predictive models based on observed data could assist practitioners in linking the genetics of the PRRS virus with clinical impact in clinical settings. Models trained in this study show promise for PRRS clinical impact prediction.
Evidence for Low Dissolved Silica in mid-Mesozoic Oceans
Authors: Yager Joyce A. , West A. Joshua , Trower Elizabeth J. , Fischer Woodward W. , Ritterbush Kathleen , Rosas Silvia , Bottjer David J. , Celestian Aaron J. , Berelson William M. , Corsetti Frank A.
Published: January 2025

The geologic history of dissolved silica concentration in the ocean (DSi) is central to understanding the evolution of silica biomineralization, the interactions between the global carbon and silicon cycles, and their combined role controlling global climate over geologic time. However, the silica cycle in the geologic past is under-constrained, especially during major mass extinction events that impacted biosilicifiers and were associated with dramatic climate change. We measured the silicon isotope ratios (δ30Si) of 76 sponge spicules from the Panthalassic Ocean spanning the Triassic–Jurassic boundary (ca. 201 Ma) to constrain DSi concentrations during the mid-Mesozoic. Spicule measurements have mean δ30Si values of –0.25‰ ± 0.99‰. Our data, combined with constraints on seawater δ30Si from coeval radiolarians, suggest that mid-Mesozoic DSi was between 20–100 µM, a similar range to the modern ocean. Our results support increasing evidence that by the Mesozoic DSi had already decreased by orders of magnitude relative to the Precambrian. These results imply that radiolarians and sponges were drawing down DSi prior to diatom ecological dominance. Increasing sponge δ30Si values across the Triassic–Jurassic boundary, coupled with modeling evidence and previous palaeoecological observations, support that warming, increased weathering, and Si delivery before the end-Triassic extinction may have facilitated sponge expansion during the extinction recovery interval.
University Management Practice: A Restorative Approach to the Dwindling Quality of University Education in Developing Countries
Authors: Ohanyelu Charles N.
Published: January 2025

The study investigates how university management practices could be applied as a novel and restorative strategy to improve the declining quality of university education in developing countries. A survey questionnaire was employed as a research tool in February-December 2022, and participants (n = 505) were selected from the total population, which comprised both management, administrative, and academic/non-academic staff of the selected universities from among the six geopolitical zones in Nigeria, using a simple random technique. The study applied Spearman’s rank-order correlation coefficient and Kruskal-Wallis tests for statistical hypothesis testing. Based on Spearman’s rank-order correlation coefficient results, hypothesis H1 was rejected, and a favorable, moderate, and statistically significant relationship between students’ academic performance and university management practice has been confirmed. At the same time, hypothesis H2 was confirmed using the Kruskal-Wallis test, and there is no statistically significant difference between students’ academic performance and the university’s geopolitical location. The study concludes that an efficient democratic management practice positively affects the overall quality output of university education. The study is unique because the principles of the University Education Quality Improvement Model (UEQI model) were applied to improve the status quo.
Harmony in Solitude: Ecological and Cultural Forces Shaping the Religious Community of the Convent of Arrábida Settlement
Authors: Medeiros Paula Antunes
Published: January 2025

From the perspective of the history of science and technology, this article explores the reasons that lie behind the choice of the Serra da Arrábida, located on the Setúbal Peninsula south of Lisbon, for the settlement of a longstanding religious community. It argues that the biophysical characteristics of the landscape’s southern slope subunit, and the cultural meaning and historical evolution of the landscape, fostered the establishment of a convent as well as of a spiritual desertum.
Human Agency and Environmental Crisis: The Autonomy of Politics between Hybridism and Dualism
Authors: Murgia André
Published: January 2025

This article aims to discuss the issue of political agency in the context of the climate crisis. In this regard, the article reports and analyzes the outlines of the debate on the relationship between human beings and the non-human world, and takes Bruno Latour’s theoretical proposal and some criticisms of it as a reference. For the most part, this debate revolves around ontological questions concerning the status of human beings in the world. Such questions provide arguments for better understanding whether politics represents an autonomous dimension in which human agency possesses a peculiar meaning or not.
Between Electoral Manipulation and Optimisation: The Dates of the Elections and the Term of Office of Self-Government in Poland from 1990 to 2024
Authors: Sieklucki Dominik
Published: January 2025

This article presents the results of research on the electoral system for local government organs. The research focused on three elements of the electoral system: the procedures for ordering elections, the dates of voting and the length of the local government’s term of office. The aim of the analysis is to describe how the local government electoral system changed in these three areas between 1990 and 2024 and to identify and explain the reasons for the changes. The article includes extensions of the self-government’s term of office until the end of April 2024.
Compound Equilibrium in a Polarized Polity — Lessons from American Democracy
Authors: Szklarski Bohdan
Published: January 2025

In the study of political systems, equilibrium stands as a cornerstone, underpinning stability and legitimacy. As we navigate the third decade of the 21st century, amid growing threats to democratic validity, it becomes crucial to re-examine this equilibrium principle. Even established democracies like the USA aren’t immune to the pitfalls of polarization, tribalization, and radicalization. In this text, we aim to explore the resilience of equilibrium in the face of these destabilizing trends. Equilibrium, traditionally viewed as a cohesive product of political competition coming as if naturally, is a mark of consolidated democracy. Yet today, as even robust democracies face internal crises, strained by polarization and fragmentation, the concept of equilibrium evolves to become a compound equilibrium consisting of disjointed axes of conflict, each seeking its individual balance. Such systems necessitate greater leadership intervention or require new rules and processes to restore cohesion. In this text we pose numerous questions about the way this process of fragmentation is overcome and compound equilibrium achieved. Interestingly, some of the measures call on limiting rather than enhancing democracy. The analysis has its historical context. Post-Cold War America exemplifies the notion that more democracy doesn’t necessarily equate to stronger democracy. While the focus here is primarily on the American system, as more democratic nations adopt its practices (such as debates and primaries), it’s hoped that insights from the USA can shed light on how democracies globally might respond to internal and external challenges to their equilibrium.
Sloyd Education for Newly Arrived Students
Authors: Gyllerfelt Emma
Published: January 2025

Swedish compulsory schools face challenges in organizing education for newly arrived students and often use practical-aesthetic subjects such as sloyd to mitigate their transition into the school system. This article presents two examples of newly arrived students in the sloyd classroom and explores the interaction, communication, and learning environment that they encounter in this context. This is done through analyzing video recorded material of sloyd lessons with newly arrived students in Years 8–9. The findings highlight that the sloyd classroom environment offers newly arrived students rich multimodal interaction and communication opportunities. Furthermore, the findings show that these students encounter complex and abstract subject-specific content and concepts in situated learning situations. The use of multimodal pedagogy enables newly arrived students to demonstrate their knowledge beyond verbal actions.
#028 Plasmocitoma ósseo solitário da maxila – Relato de um caso clínico raro
Authors:   Unidade Local de Saúde de Coimbra, Nogueira Simão , Borges Inês ,   Unidade Local de Saúde de Coimbra, Salgado Carlos ,   Unidade Local de Saúde de Coimbra, Correira José ,   Unidade Local de Saúde de Coimbra
Published: January 2025

Introdução: O plasmocitoma solitário é uma doença maligna caracterizada pela proliferação monoclonal e neoplásica de plasmócitos. Pode apresentar-se como plasmocitoma ósseo solitário (limitado a um local no esqueleto axial) ou como plasmocitoma extramedular (maioritariamente limitado aos tecidos moles). É uma doença rara (cerca de 5% das doenças malignas de células plasmáticas) e afeta com maior frequência homens com mais de 40 anos e atinge mais comumente as vértebras, sendo muito raro na maxila. O seu diagnóstico, segundo os critérios da International Myeloma Working Group, necessita das seguintes condições: biópsia de lesão com evidência de células clonais; biópsia de medula óssea normal; exames imagiológicos (tomografia computorizada/ ressonância magnética) sem evidência de outras lesões; ausência de sinais de lesão de órgão alvo, tais como como hipercalcemia, insuficiência renal, anemia e lesões ósseas ou amiloidose que possa ser atribuível a doença proliferativa dos plasmócitos. A maioria dos doentes com plasmocitoma ósseo solitário tem progressão da doença para mieloma múltiplo e a sobrevivência média global é cerca de 10 anos. Descrição do Caso Clínico: Homem, 65 anos, recorre à Urgência de Estomatologia da Unidade Local de Saúde de Coimbra devido a uma lesão na cavidade oral. Ao exame objetivo foi observada uma lesão no rebordo alveolar distal ao dente 17, circular, avermelhada e friável, com 5mm de maior eixo. Apresentava também tumefação do terço médio e posterior do palato duro. A radiografia intra-oral revelou uma hipertransparência maxilar associada à lesão. A biópsia da lesão revelou neoplasia de plasmócitos, associado a infeção por Epstein-Barr vírus. O doente foi encaminhado para a consulta de Hematologia onde realizou exames complementares de diagnóstico: estudo analítico de bioquímica e hemograma sem alterações; tomografia computorizada e PET sem evidência de outras lesões; medulograma, aspirado e biópsia de medula óssea, sem alterações. Perante os achados foi diagnosticado um plasmocitoma ósseo solitário e realizada terapêutica com radioterapia. Manteve seguimento em consulta de Hematologia. Discussão e Conclusões: Este caso pretende ilustrar que, apesar de rara, a apresentação do plasmocitoma ósseo solitário na maxila pode mimetizar diversas lesões benignas ou malignas. O seu reconhecimento é importante para que se faça um estudo diagnóstico completo, permitindo adotar a estratégia terapêutica correta e o seguimento adequado destes doentes.
Maternal satisfaction and determinants of epidural anesthesia experience in Saudi Arabian obstetric settings: a cross-sectional study
Authors: Misnid Omar , Al-Shaker Shahad , Alqalayta Jumanah , Algmaizi Shahad , Alghamdi Asayel , Alsultan Ahmed , Tawfeeq Nasser
Published: January 2025

Objective:
This study focused on evaluating maternal satisfaction with epidural analgesia in obstetric settings in Saudi Arabia. It aimed to analyze factors influencing effectiveness and satisfaction, considering issues such as postoperative pain, nausea, and varying pain relief needs.
Methods:
In this cross-sectional study, data were collected from pregnant women in Saudi Arabian obstetric settings using a structured online questionnaire. The questionnaire assessed maternal satisfaction with epidural anesthesia and related factors.
Results:
This study involved 599 participants, 222 of whom were excluded because they had not experienced epidural anesthesia. The majority of the remaining 377 women were Saudi nationals (n=336, 89.1%) aged 31–-40 years (n=183, 48.5%), with university-level education (n=300, 79.6%). Most patients were satisfied with the epidural's effectiveness during labor (n=325, 86.2%). However, 61.8% (n=233) reported side effects such as back pain (67.4%). Logistic regression showed that older women had marginally better pain relief (p-value=0.054), whereas delays in administration reduced effectiveness p-value=0.006). First-time pregnancy was associated with more effective analgesia (p-value=0.030). Side effects slightly reduced satisfaction (p-value=0.070), but no significant associations were found with sociodemographic factors, such as age or education.
Conclusion:
There was a high overall satisfaction with epidural anesthesia among Saudi women, particularly during labor. However, side effects, particularly back pain, were common. Factors such as age, timing, and employment status influenced effectiveness, whereas side effects slightly reduced satisfaction.
DIGITALISASI PEMBELAJARAN: SOLUSI MENINGKATKAN MOTIVASI BELAJAR SISWA SMK BUSTANUL ULUM NONGGUNONG
Authors: Arifin Miftahul , Helmi Fauzi , Dharmawan Johan
Published: January 2025

Penggunaan teknologi dalam pembelajaran telah menjadi kebutuhan mendesak untuk meningkatkan motivasi belajar siswa, terutama di era digital. Program pengabdian kepada masyarakat ini bertujuan untuk meningkatkan keterampilan guru dan motivasi belajar siswa di SMK Bustanul Ulum Nonggunong melalui pelatihan aplikasi Quizizz. Kegiatan dilaksanakan pada tanggal 29 November 2024, dengan tahapan persiapan, pelaksanaan, dan evaluasi. Hasil menunjukkan bahwa 85% guru merasa lebih percaya diri menggunakan Quizizz, dan 90% siswa merasa lebih termotivasi belajar melalui fitur gamifikasi yang ditawarkan. Meskipun terdapat kendala teknis berupa koneksi internet yang kurang stabil, pelatihan ini berhasil memberikan dampak positif pada proses pembelajaran. Tindak lanjut berupa peningkatan infrastruktur teknologi dan pendampingan lanjutan bagi guru direncanakan untuk memastikan keberlanjutan program. Dengan hasil ini, pelatihan Quizizz dapat dijadikan model untuk meningkatkan kualitas pembelajaran berbasis digital di sekolah lain.
POSSIBLE PHARMACOLOGICAL BASIS FOR ANTITHROMBOTIC EFFECT OF GLYCYRRHIZA GLABRA IN SPRAGUE DAWLEY RATS
Authors: Jain M. , Yadav A. , Tomar V. , Kannojia P. , Solanki S. S. , Tonpay S. D.
Published: January 2025

It has been previously identified that 3-aryl comarin derivative, GU-7 isolated from Liquorice posses Antiplatelet activity. It inhibits platelet aggregation by increasing intraplatelet cyclic AMP concentration. Here we report the in-vivo effects of extract of Glycyrrhiza glabra and also the combined effect with Vitamin K and Heparin. Extract of Glycyrrhiza glabraincreased the bleeding time when given in the doses of 180 mg/kg and 360 mg/kg. Blood loss was evaluated 60 minute later as a function of absorbance at 540 nm due to hemoglobin content in water solution. Altogether data indicates that Glycyrrhiza glabra is an effective anti thrombotic agent in vivo, which may account for its known pharmacological properties.
ANALGESIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF PAVETTA INDICA
Authors: Golwala D. K. , Patel L. D. , Bothara S. B. , Patel P. M. , Vaidya S. K. , Raval M. K.
Published: January 2025

The present study was designed to investigate Analgesic activity of ethanolic leaf extract of Pavetta indica, using hot plate method and tail clip method. Ethanolic extract was administered intraperitoneally at doses of 60 mg/kg and 80 mg/kg to Swiss albino mice and Wister rats. Ethanolic leaf extract of Pavetta indica showed significant (p<0.01) inhibition in pain response induced by thermal and mechanical stimuli in dose dependent manner. The obtained results provide promising baseline information for the potential use of these crude extract in the treatment of pain.
APPLICATION OF SOME NOVEL TECHNIQUES FOR SOLUBILITY ENHANCEMENT OF MEFENAMIC ACID, A POORLY WATER SOLUBLE DRUG
Authors: Kumar Sanjeev , Parkash Chander , Kumar Pradeep , Singh Shailendra Kumar
Published: January 2025

Mefenamic acid (MFA), a potent non-steroidal anti-inflammatory drug (NSAID), has a low oral bioavailability due to poor aqueous solubility and insufficient dissolution. In order to improve the same, various techniques were employed viz., evaporative precipitation into aqueous solution (EPAS), spherical agglomeration (SA) and solid dispersion using solvent evaporation and melt mixing. The formulations were characterised by differential scanning calorimetry (DSC) and X-Ray powder diffractometry (XRD) and were investigated for drug content studies, solubility studies, in vitro study and in vivo evaluation of anti-inflammatory activity. The formulations of MFA prepared by spherical agglomeration technique have satisfactory good drug content and the formulations with SLS and HPMC show a significant increase in solubility in case of SA technique. In case of solid dispersion, all carriers show improvement in the dissolution rate of the drug The DSC studies show no change in the polymorphism in most of the formulations The XRD studies of the formulations show no change in their crystalline form. The formulation containing HPMC & SLS as drug carrier show better anti-inflammatory effect with comparison to pure drug confirming the improved bioavailability of this drug.
HYPOGLYCEMIC AND ANTIHYPERLIPIDAEMIC EFFECT OF ETHANOLIC EXTRACT OF AERIAL PARTS OF AERVA LANATA LINN. IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS
Authors: Krishnan G. Appia , Rai V. K. , Nandy B. C. , Meena K. C. , Dey S. , Tyagi P. K. , Tyagi L. K.
Published: January 2025

The present study was designed to evaluate the preliminary phytochemical investigation of Aerva lanata Linn. (Family, Amaranthaceae), and anti-diabetic effect of Arial parts of plant Aerva lanata Linn. in normal and Alloxan induced diabetic rats. Ethanolic extract of Arial part of Aerva lanata Linn. were evaluated for four weeks treatment for hypoglycemic activity in diabetic albino rats; at doses of 50,100 and 200 mg kg -1 body weight ,its effects on the blood glucose and other biochemical parameters like cholesterol, urea, creatinine, billirubin and SGPT in Alloxan induced diabetic rats were investigated. Diabetes was introduced by single tail-vein injection of Alloxan (60 mg kg -1). Oral administrations of Aerva lanata Linn. extract to diabetic animals up to four weeks; dose dependently reduced the blood glucose level, which is comparable to standard dose of Metformin. Significantly decreased in body weight was observed with diabetic control, which was partially restored upon administration Aerva lanata Linn. extract (50, 100, 200 mg kg -l). Alcoholic extract of Arial part of A. lanata Linn. also altered other biochemical parameters level. It was concluded from the results that the alcoholic extract of A. lanata Linn. possesses anti-diabetic effect in experimental animals.
VEGF INHIBITORS FOR CANCER THERAPY
Authors: Sukhramani Prakash S. , Suthar Maulik P.
Published: January 2025

Despite significant advances in systemic therapies, radiation oncology, and surgical techniques, many patients with cancer are still incurable. A novel therapeutic approach has been to target the vascular endothelial growth factors (VEGFs) which are often mutated and/or over-expressed in many tumors. The ligands and receptors of VEGF family are well established as key regulators of angiogenesis and vasculogenesis processes. VEGF is a homodimeric, basic, 45 kDa glycoprotein specific for vascular endothelial cells. Specifically, VEGF participates in regulation of the female reproductive cycle, wound healing, inflammation, vascular permeability, vascular tone, hematopoiesis and also contributes to pathological angiogenesis disorders such as cancer, rheumatoid arthritis, diabetic retinopathy and the neovascular form of macular degeneration. Thus, the role of VEGF has been extensively studied in the pathogenesis and angiogenesis of human cancers. Clinical trials have anti-VEGF therapies are effective in reducing tumor size, metastasis and blood vessel formation. Clinically, this may result in increased progression free survival, overall patient survival rate and will expand the potential for combinatorial therapies. The aim of present review is on the cellular responses of VEGF inhibitors and their implications for cancer therapy.
PREPARATION AND EVALUATION OF TOPICAL GEL OF VALDECOXIB
Authors: Jani Rupal , Jani Kaushal , Setty C. Mallikarjuna , Patel Dipti
Published: January 2025

Topical gels of Valdecoxib topical gel prepared using different gelling agents (Viz, carbopol, HPMC, sodium alginate, sodium CMC). Formulations were evaluated for pH, rheological behavior, drug content and in vitro drug diffusion. Selected formulations of all the gelling agents appeared to be non-Newtonian and pseudo plastic behavior. Drug content was high (>98 %) in gels. Drug release from the carbopol gels increased with the increase in the concentration of PG up to 10 %. However, drug release decreased as the concentration of the PG increased to 20 %. The drug release increased with the increase in concentration of ethanol. In case of gels containing HPMC, sodium alginate, sodium CMC as gelling agents, addition of PG up to 5 %, increased the release of drug from the gels. However, release decreased with increase in the concentration of PG up to 10 %. In case of HPMC gels, addition of ethanol decreased the release of Valdecoxib from the gels. It is concluded that PG is a good penetration enhancer and carbopol good gelling agent for Valdecoxib gels.
FORMULATION AND CHARACTERIZATION OF FAST-DISSOLVING TABLETS OF RALOXIFENE HYDROCHLORIDE
Authors: Prasanthi N. L. , Manikiran S. S. , Rao N. Rama
Published: January 2025

Fast Dissolving Tablet (FDT) of Raloxifene was prepared by direct-compression method by incorporating super disintegrants like crosscarmellose sodium and sodium starch glycolate. The study was performed by incorporating the super disintegrants in 2 % and 4 % concentration for each and 2 % - 2 % in combination of both super disintegrants. Five formulations having super disintegrants at different concentration levels were prepared to assess their efficiency. Different types of evaluation parameters for tablets were performed. Tablets containing super disintegrants in combination showed excellent in vitro dispersion time and drug release as compared to other formulations.
SPECTROPHOTOMETRIC QUANTITATIVE ESTIMATION AND VALIDATION OF NIMESULIDE AND DROTAVERINE HYDROCHLORIDE IN TABLET DOSAGE FORM
Authors: Prasad K. R. , Sharma R.
Published: January 2025

Three simple, sensitive and accurate UV spectrophotometric methods, I; first order derivative spectrophotometric, II; area under curve and III; multi-component method, has been developed for the estimation of drotaverine hydrochloride and nimesulide in tablets dosage form. Beers’ law was obeyed in the concentration range 5-35 µgml-1 and 10-50 µgml-1 for drotaverine (λmax = 230.5 nm) and nimesulide (λmax = 331.5 nm) respectively in methanol. All the three methods allowed rapid analysis of binary pharmaceutical formulation with accuracy. Results of analysis for three methods were tested and validated for various parameters according to ICH guidelines.
LAWSONIA INERMIS LINNAEUS: A PHYTOPHARMACOLOGICAL REVIEW
Authors: Chaudhary Gagandeep , Goyal Sandeep , Poonia Priyanka
Published: January 2025

Lawsonia inermis L. is a much branched glabrous shrub or small tree, cultivated for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. The plant is reported to contain carbohydrates, proteins, flavonoids, tannins and phenolic compounds, alkaloids, terpenoids, quinones, coumarins, xanthones and fatty acids. The plant has been reported to have analgesic, hypoglycemic, hepatoprotective, immunostimulant, anti-inflammatory, antibacterial, antimicrobial, antifungal, antiviral, antiparasitic, antitrypanosomal, antidermatophytic, antioxidant, antifertility, tuberculostatic and anticancer properties. It is now considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products. This review gives a bird’s eye view mainly on the pharmacognostic characteristics, traditional uses, phytochemistry and pharmacological actions of the plant.
DESIGN AND CHARACTERIZATION OF AMOXICILLIN TRIHYDRATE MUCOADHESIVE MICROSPHERES FOR PROLONGED GASTRIC RETENTION
Authors: Yellanki Shiva Kumar , Singh Jeet , Syed Jawad Ali , Bigala Rajkamal , Goranti Sharada , Nerella Naveen Kumar
Published: January 2025

Whilst there is keen interest in developing improved drug delivery systems to gastro intestinal tract for treatment of Helicobacter pylori induced peptic and duodenal ulcers, In an effort to augment the anti-Helicobacter pylori effect of Amoxicillin trihydrate mucoadhesive microspheres, which have the ability to reside in the gastrointestinal tract for an extended period, were prepared with ethyl cellulose as a matrix and carbopol 934P as a mucoadhesive polymer. Particle size was determined by optical micrometer and average particle size was found in the range of 500-560 m for all batches. All the batches showed good in vitro mucoadhesive property. Cumulative percent drug release was found to be maximum for FI (91.12 %). Formulation FII found to follow Higuchi matrix with the regression value of 0.9985. Form the all batches FI formulated microspheres showed more mucoadhesive property due to less amount of ethyl cellulose. In conclusion, the prolonged gastrointestinal residence time and controlled release might make contribution to H. Pylori clearance.
SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(THIAZOLIDIN-4-ONE) PHENYL]-1H-PHENYLBENZIMIDAZOLES AND 2-[4-(AZETIDIN-2-ONE)-3-CHLORO-4- PHENYL] -1H-PHENYL BENZIMIDAZOLES
Authors: Shanmugapandiyan P. , Denshing K. S. , Ilavarasan R. , Anbalagan N. , Nirmala R.
Published: January 2025

A new series of 2-[4-(azetidin-2-one)-3-Chloro-4-phenyl]-1H-Phenylbenzimidazoles and 2-(thiazolidin-4-one)-Phenyl]-1H-Phenylbenzimidazoles were synthesized by the reaction of schiff base [2-(4-aminophenyl)-Benzimidazole and substituted Benzaldehyde] with chloroacetyl chloride and mercaptoacetic acid respectively. The chemical structures of the synthesized compounds were confirmed by IR, 1H-NMR, mass spectral and C, H, N analysis. The synthesized compounds were screened for antibacterial (Bacillus cereus, Escherichia coli, Micrococcus luteus, Klebssiela pneumoniae, Staphylococcus aureus and Salmonella epidermidis), antifungal (Aspergillus niger and Candida albicans), analgesic activity by writhing reflex method and anti-inflammatory activity by carrageenan induced paw edema method. The synthesized compound showed significant activity of antibacterial, antifungal, analgesic and anti-inflammatory activity comparable to that of standard.
SUB-ACUTE TOXICITY STUDY OF ETIMICIN SULPHATE IN WISTAR RAT
Authors: Payasi Anurag , Chaudhary Manu , Tamta Anupama , Dwivedi Vivek K.
Published: January 2025

The aim of the present study was to evaluate subacute toxicity of etimicin sulphate on wistar rat. Results from the present study have elucidated that treatment of etimicin sulphate exerts no significant signs of toxicity at any dose level used in the study. Physical, biochemical as well as hematological parameters was unaltered throughout the study. Histopathology of all organs confirmed no significant alteration at any dose levels. The results of study have suggested there was no obvious toxicity observed with the treatment of etimicin sulphate. It was found to be safe alternative for various severe infections.