bluuebunny/crossref_metadata_2025 huggingface dataset:
Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81
Authors: Chabert Valentin , Kim Geun-Don , Qiu Danye , Liu Guizhen , Michaillat Mayer Lydie , Jamsheer K Muhammed , Jessen Henning J , Mayer Andreas
Published: September 2023

Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway that utilizes inositol pyrophosphates and SPX receptor domains. Since cells synthesize various inositol pyrophosphates and SPX domains bind them promiscuously, it is unclear whether a specific inositol pyrophosphate regulates SPX domains in vivo, or whether multiple inositol pyrophosphates act as a pool. In contrast to previous models, which postulated that phosphate starvation is signaled by increased production of the inositol pyrophosphate 1-IP7, we now show that the levels of all detectable inositol pyrophosphates of yeast, 1-IP7, 5-IP7, and 1,5-IP8, strongly decline upon phosphate starvation. Among these, specifically the decline of 1,5-IP8 triggers the transcriptional phosphate starvation response, the PHO pathway. 1,5-IP8 inactivates the cyclin-dependent kinase inhibitor Pho81 through its SPX domain. This stimulates the cyclin-dependent kinase Pho85-Pho80 to phosphorylate the transcription factor Pho4 and repress the PHO pathway. Combining our results with observations from other systems, we propose a unified model where 1,5-IP8 signals cytosolic phosphate abundance to SPX proteins in fungi, plants, and mammals. Its absence triggers starvation responses.
Control of meiotic entry by dual inhibition of a key mitotic transcription factor
Authors: Su Amanda J , Yendluri Siri C , Ünal Elçin
Published: September 2023

The mitosis to meiosis transition requires dynamic changes in gene expression, but whether and how the mitotic transcriptional machinery is regulated during this transition is unknown. In budding yeast, SBF and MBF transcription factors initiate the mitotic gene expression program. Here, we report two mechanisms that work together to restrict SBF activity during meiotic entry: repression of the SBF-specific Swi4 subunit through LUTI-based regulation and inhibition of SBF by Whi5, a functional homolog of the Rb tumor suppressor. We find that untimely SBF activation causes downregulation of early meiotic genes and delays meiotic entry. These defects are largely driven by the SBF-target G1 cyclins, which block the interaction between the central meiotic regulator Ime1 and its cofactor Ume6. Our study provides insight into the role of SWI4LUTI in establishing the meiotic transcriptional program and demonstrates how the LUTI-based regulation is integrated into a larger regulatory network to ensure timely SBF activity.
YAP1 affects the prognosis through the regulation of stemness in endometrial cancer
Authors: Kong Wei , Huang Yuzhen , Jiang Peng , Tu Yuan , Li Ning , Wang Jinyu , Zhou Qian , Zheng Yunfeng , Gou Shikai , Tian Chenfan , Yuan Rui
Published: September 2023

Background

Endometrial cancer stem-like cells (ECSCs) have been proven to be responsible for recurrence, metastasis, and drug-resistance in patients with endometrial cancer. The HIPPO pathway has been shown to play an important role in the development and maintenance of stemness in a variety of tumors. While there was less research about its function in ECSCs. The aim of this study was to explore the role of YAP1, a core molecular of HIPPO pathway, in the stemness of endometrial cancer and to reveal its influence on prognosis.

Methods

We collected specimens and clinical data from 774 patients with endometrial cancer to analyze the correlation between YAP1 expression and prognosis. We then examined the expression of YAP1 in ECSCs and EC cell lines (Ishikawa; HEC1-A) in vitro experiments. Changes in the stemness of cell lines were detected after YAP1 silencing by siRNA. Finally, high-throughput sequencing was used to predict the potential molecular interactions and mechanisms of YAP1’s effect on stemness.

Result

Down-regulation of YAP1 significantly suppresses the stemness of EC cell lines. High expression of YAP1 leads to poor prognosis in EC by regulation of stemness.

Conclusion

YAP1 plays an important role in the prognosis of patients with EC by regulation of stemness.
Metabolomics profiling reveals differences in proliferation between tumorigenic and non-tumorigenic Madin-Darby canine kidney (MDCK) cells
Authors: Sun Na , Zhang Yuchuan , Dong Jian , Liu Geng , Liu Zhenbin , Wang Jiamin , Qiao Zilin , Zhang Jiayou , Duan Kai , Nian Xuanxuan , Ma Zhongren , Yang Xiaoming
Published: September 2023

Background

Madin-Darby canine kidney (MDCK) cells are a cellular matrix in the production of influenza vaccines. The proliferation rate of MDCK cells is one of the critical factors that determine the vaccine production cycle. It is yet to be determined if there is a correlation between cell proliferation and alterations in metabolic levels. This study aimed to explore the metabolic differences between MDCK cells with varying proliferative capabilities through the use of both untargeted and targeted metabolomics.

Methods

To investigate the metabolic discrepancies between adherent cell groups (MDCK-M60 and MDCK-CL23) and suspension cell groups (MDCK-XF04 and MDCK-XF06), untargeted and targeted metabolomics were used. Utilizing RT-qPCR analysis, the mRNA expressions of key metabolites enzymes were identified.

Results

An untargeted metabolomics study demonstrated the presence of 81 metabolites between MDCK-M60 and MDCK-CL23 cells, which were mainly affected by six pathways. An analysis of MDCK-XF04 and MDCK-XF06 cells revealed a total of 113 potential metabolites, the majority of which were impacted by ten pathways. Targeted metabolomics revealed a decrease in the levels of choline, tryptophan, and tyrosine in MDCK-CL23 cells, which was in accordance with the results of untargeted metabolomics. Additionally, MDCK-XF06 cells experienced a decrease in 5’-methylthioadenosine and tryptophan, while S-adenosylhomocysteine, kynurenine, 11Z-eicosenoic acid, 3-phosphoglycerate, glucose 6-phosphate, and phosphoenolpyruvic acid concentrations were increased. The mRNA levels of MAT1A, MAT2B, IDO1, and IDO2 in the two cell groups were all increased, suggesting that S-adenosylmethionine and tryptophan may have a significant role in cell metabolism.

Conclusions

This research examines the effect of metabolite fluctuations on cell proliferation, thus offering a potential way to improve the rate of MDCK cell growth.
Identification of Dioscorea opposite Thunb. CDPK gene family reveals that DoCDPK20 is related to heat resistance
Authors: Gao Yuanli , Zhang Yanfang , Ji Xiang , Wang Jinxin , Suo Ningning , Liu Jiecai , Huo Xiuwen
Published: September 2023

Temperature affects the growth and yield of yam (Dioscorea opposite Thunb.), and calcium-dependent protein kinases (CDPKs) play an important role in the plant stress response. However, there has been a lack of system analyses of yam’s CDPK gene family. In this study, 29 CDPK transcriptome sequences with complete open reading frames (ORFs) were identified from yam RNA sequencing data. The sequences were classified into four groups (I–VI) using phylogenetic analysis. Two DoCDPK genes were randomly selected from each group and the gene patterns of yam leaves were determined using quantitative real-time PCR (qRT-PCR) under high and low temperature stress in order to show their unique functions in mediating specific responses. Among them, DoCDPK20 was significantly induced in high temperatures. The pPZP221-DoCDPK20 was transformed into tobacco leaves using an agrobacterium-mediated method. Under high temperature stress, DoCDPK20 overexpression reduced photosynthesis and improved heat tolerance in transgenic tobacco. Our research offers meaningful perspectives into CDPK genes and new avenues for the genetic engineering and molecular breeding of yam.
Application of Technical Rationality and Reflective Practice in Managing Intricate Construction Claims: A Case Study in Qatar
Authors: Jayalath Chandana
Published: September 2023

The propensity towards the increased number of court cases, gaps between theory and practice and the intricacy associated with construction claims tend to pose messy and indeterminate situations where the traditional instrumental approaches are criticised for sub-optimal outcomes. This essentially warrants some kind of a reflection in action merged with technical rationality in making professional judgments. There  is  little  to  no  literature  on  how  construction practitioners synthesize  both  paradigms  within  a  single  project,  reinforcing  the  apparent  divide between  them. This study therefore explores the potential of implementing reflective practice into construction claim analysis by using a case study. The project selected was a 12 km bypass in Doha Qatar consisting of a 10-lane section which provided qualitative data related to 19 contractual heads that are recognized as being effectively and amicably settled. The literature shows 17 characteristics of each domain. The study emphasized that two paradigms (technical rationality and reflective practice) are not remote, but concomitant with several discrete relationships. Recommendations were given for construction practitioners to use reflective practice, along with technical rationality to submit sensible claims and frame out solutions for future applications. It is apparent that the use of algorithms, industrial knowhow and thumb rules provide stimuli in claims analysis combining both the paradigms fostering a culture of sensible claims.
Effectiveness of Extension Communication Channel in the Adoption Process of Hermetic Bag Storage Technology in Nakuru, Kenya
Authors: Muriuki N. N. , Munyua C. N. , Odero-Wanga D. A.
Published: September 2023

This study sought to examine effectiveness of extension communication channel on adoption process of hermetic bag storage technology. This was prompted by the various maize post-harvest losses experienced by farmers despite maize being staple food in Kenya. Correlational study design was employed while proportional simple random sampling technique was used to obtain a sample size of 120 farmers in the Njoro, Molo and Rongai sub-counties of Nakuru County. Content and face validity was assessed by subjecting the instrument to critique by experts in Egerton University. Cronbach alpha was used to estimate the reliability of the research instruments and was found to be 0.848. Descriptive statistics (means, percentages and standard deviation) and inferential statistics (Pearson correlation) were employed for data analysis. Pearson correlation coefficient analysis was used to test the hypotheses at significant level of α = 0.05. The results indicated that Pearson Correlation was highest at the decision-making stage 0.853 followed by the persuasion stage at 0.651, adoption stage at 0.624 then implementation stage came fourth at 0.466 and finally awareness stage at 0. 363. Therefore the study established that extension communication channel is effective in adoption process of hermetic bag storage technology. This is with strong positive influence at decision stage and weak positive influence at awareness stage of the adoption process. The study hence that Government should come up with policies to support extension service to facilitate the adoption of hermetic bag storage technology and hence attain food security.
Navigating the Financial Landscape: Unravelling the Interplay between Current Liabilities and Profitability in Nigerian Consumer Goods Sector
Authors: Titilayo Ekuma, Mojibade , Inyiama Oliver Ike , Okwo Ifeoma Mary
Published: September 2023

The study evaluated the effect of current liabilities on profitability of consumer goods firms in Nigeria.  The specific objectives of the study were to assess the effects of accounts payable, income tax payable and dividend payable on profit for the year of firms in the consumer goods industry in Nigeria. Data were collected from annual reports and accounts of sampled firms within the industry to test the major null hypothesis that selected current liabilities do not affect profit for the year significantly. Multiple regression was the tool of analysis using panel data set covering 30 observations from three firms in the consumer goods industry. The findings revealed that Accounts Payable (AP) has a negative (Coefficient -0.106881) but significant effect (p-value 0.0004) on Profit for the Year (PFY), Income Tax (IT) has a positive (Coefficient 2.103591) and significant effect (p-value 0.0000) on Profit for the Year, while Dividend payable (DP) has negative (Coefficient -0.302978) and non-significant (p-value 0.2772) effect on Profit for the Year in consumer goods firms in Nigeria. The implication of the findings is that the effect of current liabilities on profit for the year in the industry depends on factors of environment, credit policies, nature of products, distribution channels and corporate governance mechanisms. The study concluded that trade creditors and dividend payables should be reduced while income tax be allowed to flow in tandem with the accounting profit for the year. The study recommended that firms should reduce the list and amount of trade creditors, government should judiciously invest tax revenues in infrastructural development and firms’ growth should be pursued through retained earnings.
Phytochemical and Nutritional Profile, Mineral Ratio and Mineral Safety Index of Young and Matured Corn Silk Collected from Ekiti State, Nigeria
Authors: Dele Oyeyemi. S. , Raymond O.
Published: September 2023

Corn silk is an agricultural waste material from corn cultivation. The need for a supplement feed material that would be readily available, affordable and has nutritional qualities prompted this study. Fresh and dry corn silk were collected from a farm land in Ado Ekiti, Ekiti State, Nigeria and evaluated for phytochemical and nutritional composition using standard techniques. The phytochemical analysis revealed that both the young and matured corn silk contained alkaloids, tannins, saponins, flavonoids, phenols, steroids and reducing sugar. The qualitative phytochemical estimates showed high concentration of flavonoids and total phenols while tannins were found in moderate quantities. The proximate estimation (%) revealed high values of carbohydrate and crude fiber, moderate crude protein and ash, low crude fat, low  moisture as well as high energy content in young and matured corn silk respectively. Both samples contained high K, P, Ca, Mg, moderate Na, Fe, Mn, Zn and Cu while Pb and Ni, toxic metals, were absent. The results showed low mineral CV% which ranged from 1.32-38.92. The results of the mineral safety index were lower than the standard, an indication that there would be no mineral overload. The two corn silk samples were rich in active secondary metabolites which could offer protective health benefits, also safe and contained nutritional qualities that could make them suitable to be incorporated into man’s diet and domestic feed.
Social Discrimination in Public Space: From the Perspectives of Migrant Workers in the Informal Sector in Hanoi
Authors: Luong Duong Thuy
Published: September 2023

The article focused on answering the following research questions: 1) What are the perceptions of migrant workers in the informal sector towards social discrimination against them when coming to public space? 2) Are there any differences of opinions between migrant groups working in the informal sector about this issue by gender, age and type of migration? The quantitative data collected by survey questionnaires among migrant workers in the informal sector were used for analysis with the differences of opinions across groups classified by gender, age and type of migration. While the findings indicated a neutral viewpoint among those, it also highlighted differences across groups by gender and type of migration.
Zero Tillage Lead to Enhanced Productivity and Soil Health
Authors: Kumari Alisha , Ashoka P  , Tiwari Purvi , Sachan Prashun , Malla Aditya Kumar , Tripathy Abhisek , Chowdhury Manojit
Published: September 2023

Zero Tillage (ZT) is a critical agricultural practice that emphasizes minimal soil disturbance. This study explores the future prospects of ZT, focusing on three essential dimensions: technological advancements, climate change considerations, and potential growth in adoption rates. The technological innovations in precision agriculture, robotics, artificial intelligence, and biotechnology are found to play a pivotal role in enhancing the efficiency and sustainability of ZT. These advances allow for more intelligent and targeted approaches, reducing waste and aligning farming practices with broader sustainability goals. Climate change also plays a significant role in shaping ZT's future. ZT's inherent properties of soil moisture conservation, reduced erosion, and carbon sequestration make it a valuable strategy for climate mitigation and adaptation. The study reveals that the global urgency to address climate change might act as a catalyst for ZT's growth, aligning it with key strategies in future agriculture. The potential growth in ZT adoption rates is examined in light of these technological and environmental factors. The findings suggest that technology's role in lowering barriers and enhancing effectiveness, combined with governmental and organizational support, could drive broader adoption of ZT, particularly in developing countries. Collaborative efforts among various stakeholders, including researchers, policymakers, farmers, and industry, are highlighted as essential to optimize ZT for diverse contexts and needs. The future prospects of Zero Tillage are rich and multifaceted, marked by technological innovation, alignment with climate goals, and a clear path toward broader adoption. The integration of these factors creates a promising landscape for ZT, positioning it as a pivotal practice in shaping sustainable agriculture for the future. This study contributes to the understanding of ZT's future trajectory and offers insights that can guide its continued evolution and impact in the agricultural sector.
Effect of Indole-3-Acetic Acid and Nano-Urea on Agronomic Properties of Radish Crops
Authors: Soni Sahil , Sharma Indu
Published: September 2023

This study aimed to evaluate the impact of nano-urea, indole-3-acetic acid (IAA), phosphorus (P), and potassium (K) on seed germination and various growth parameters of Raphanus sativus L. The experiment was carried out in a randomized block design with three replicates per treatment and a total of eight treatments. Both nano-urea and IAA were applied through foliar spray whereas P and K were given as in-soil treatment. The seed germination centage was measured on the 14th day after sowing. The results demonstrated that all treatments improved seed germination compared to the control. Nano-urea alone increased the germination percentage from 40.83% to 54.16%, while the combination of nano-urea and IAA further enhanced it to 67.5%. The highest germination percentage of 75.83% was achieved with the simultaneous application of nano-urea, IAA, P and K. Additionally, the treatments influenced the number of leaves at different stages of growth. The treatment with IAA, nano-urea, P and K resulted in the highest leaf count of 61.26. Moreover, the length of leaves, roots, and shoots were significantly affected by the treatments. The combination of foliar applications of IAA (auxin) and nano-urea; and in soil treatments of P and K resulted in the longest leaf, root, and shoot lengths. These findings highlight the positive effects of the tested treatments on seed germination and various growth parameters of Raphanus sativus L. The results contribute to our understanding of the potential applications of nano-urea, IAA, P and K in improving crop productivity and growth. This information can aid in the development of sustainable agricultural practices for enhanced crop performance and yield.
In silico Analysis of 7-Dehydrocholesterol Reductase Gene (Sl7-DR2) in Tomato: Linking Cholesterol Metabolism to Vitamin D Pathway
Authors: Diwakar Poleboina Venkata , Arul L. , Saraswathi T. , Varanavasiappan S. , Saranya N. , Kumar K. K.
Published: September 2023

Tomatoes are the most popular vegetable crop worldwide and contain many health-promoting compounds. Most foods contain very little amount of vitamin D, and plants are very poor sources in the production of vitamin D. The 7-dehydrocholesterol reductase gene (Sl7-DR2) is responsible for the accumulation of 7-dehydrocholesterol, which is a precursor for vitamin D3 synthesis. This gene is present in different plant species and plays a role in cholesterol metabolism as well as it links with the vitamin D pathway by inhibiting its actual function in the synthesis of cholesterol. In this study, sequencing analysis of the gene using multiple sequence alignment provided information about its similarity and their conserved sequence regions in different plant species. Using MEGA11 software, the phylogenetic analysis of this gene was done and it showed that, this gene present in chromosome 6 and chromosome 1 of Solanum lycopersicum has a close resemblance with Solanum tuberosum and Datura stramonium respectively. The physiochemical characteristics of Sl7-DR2 were analyzed by using the Expasy protparam tool. Functional annotation and secondary structure analysis of Sl7-DR2 were done using the Pfam, STRING, and SOPMA databases. The results obtained from this analysis showed that the protein was stable and has a low GRAVY Index indicating its higher affinity to water and the secondary structure analysis predicts the robust nature of this protein and the STRING analysis gave information related to proteins that are involved in the sterol pathway and their functions. These tools characterized the protein function of the Sl7-DR2 gene and studied the role of 7-dehydrocholesterol reductase in converting 7-dehydrocholesterol to vitamin D3 and its role in cholesterol metabolism. The pathway analysis using the Reactome database helps in characterizing the network between the cholesterol and vitamin D pathway. The 3D structure of the Sl7-DR2 protein was predicted using an ab initio approach, Robetta, and the predicted structure was validated using the SAVESv6.0 (PROCHECK) server. The predicted model has 90.8% of total residues present in the most favoured regions and showed high readability and quality. These analyses demonstrated the significance of this gene in the vitamin D pathway and its potential for human health in preventing various diseases.
Effect of Spacing and Foliar Spray of Liquid Organic Manures on Yield and Economics of Zaid Groundnut (Arachis hypogea)
Authors: Sriram Dulam , Singh Rajesh , Indu Thakur
Published: September 2023

The field experiment entitled “Effect of spacing and foliar spray of liquid organic manures on Yield and Economics of zaid groundnut (Arachis hypogea)”was conducted during rabi season, 2022 at Crop Research Farm in the Department of agronomy, Naini Agriculture Institute, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj Uttar Pradesh. The treatment consisted of Row spacing 50 x 10 cm, 60 x 10 cm, 70 x 10 cm and Liquid Organic formulation panchagavya 3%, vermiwash 10%, Cow urine 10% and control. The experiment was layout in Randomized Block Design (RBD) with 10 treatments and replicated thrice. Application of (Spacing 60x10 cm + Cow urine 3%) produces higher pod yield (3053 kg/ha.), Haulm yield (5142 kg/ha.), Gross Return (INR 124106/ha.), Net Return (INR 77696/ha.) and B:C Ratio (2.67).
Assessing the Baseline Sensitivity of Predominant Soil-Borne Pathogens against Carbendazim
Authors: Kundargi Chandana Y. , Johnson I. , Karthikeyan M. , Anandham R. , Jayakanthan M.
Published: September 2023

Fungicide resistance is reducing the effectiveness of fungicides in controlling plant diseases, leading to increase crop losses and the need for alternative control strategies. Addressing this issue requires careful fungicide use and the development of new management approaches. The main objective of present study was to determine the baseline sensitivity and development of fungicide resistance in predominant soil-borne pathogens against carbendazim at various concentrations. It was observed that the EC50 of Fusarium oxysporum and Macrophomina phaseolina was 9.970 and 16.294 µg ml-1, respectively. The baseline sensitivity of both fungi was determined based on the inhibition percentage at which the pathogen showed sensitivity. Repeated transfer of these cultures at same concentrations for some generations showed the progressive decline in growth inhibition across generations resulting in the development of fungicide resistance. These studies have demonstrated that overreliance on certain fungicides can lead to the development of resistant fungal strains, compromising the efficacy of disease management. This emphasizes alternative use of fungicides with different mode of action or following integrated disease management strategies to mitigate fungicide resistance and sustainably protect crops.
Comparative Analysis of the Essential Oil Contents of Azadrichta indica and Humulus lulpulus: Could Azadrichta indica Substitute Humulus lulpulus in Beer Brewing?
Authors: Agu Matthew Onyema , Tabugbo Blessing Ifeyinwa , Okafor Vincent Nwalieji , Ikeji Maryjane Onyinyechi
Published: September 2023

Hops (Humulus lulpulus) give beer its brewing qualities (iso-alpha acid and essential oil). Hop acid is responsible for bitterness while hop essential oil is responsible for aroma and palate fullness. The aim of the study is to investigate the potentiality of substituting hop oil with neem (Azadrichta indica) oil in beer brewing. The oils were analyzed using Fourier-Transform Infrared (FTIR) spectroscopic technique after extracting the oil by solvent extraction. Hydrocarbon and Sulphur contents were also investigated using their standard methods. FTIR results show that both oils contain similar functional groups.  It was observed that some hydrocarbons (myrcene, ocimene and α and β-pinene) present in essential oil of hop were also present in neem leaf oil.  Volatile sulphur compounds such as dimethyl sulphide, dimethyl disulphide and dimethyl trisulphide present in hop oil were also found in neem oil. This study revealed that neem oil could be used as a substitute for hop oil in aroma enhancement in beer.
Determination of Gender Variations Based on Anatomical Shapes of the Orbit on Plain Radiographs of Nigerians: A 5-Year Retrospective Cross-Sectional Study
Authors: Bello A.  , Usman J. D.
Published: September 2023

Introduction: Cephalometry has been widely used in substantial aspects of medicine. There exist obvious differences between male and female bony features from early development to adulthood. The morphometric examination of the orbit and familiarity with its anatomy are important clinically in the diagnosis of orbital lesions and face reconstructive surgery. Diagnostic radiology and ophthalmology have a close relationship. Most prior research assessed orbital dimensions using direct approaches on living, cadaveric, or dry bones.

Aim: To determine the gender variations based on the shapes of the orbit using Plain Radiographs.

Materials and Methods: A 5-year retrospective cross-sectional study using 255 normal skull radiographs obtained from the Department of Diagnostic Radiology of Usmanu Danfodiyo University Teaching Hospital Sokoto from 2004 40 2009 was carried out with male to female ratio of 4:1. The radiographs were mounted on a viewing box, and the orbital shapes were noted. Results: In the male subjects, the shape of the orbit was oval in 68 (33.0%), quadrangular in 55 (26.7%), and round in 83 (40.3%). In the female subjects, the oval-shaped orbit was found in 27 (55.1%), quadrangular shape in 12 (24.5%), and in round shape 10 (20.4%).

Conclusions: The commonest type of orbit seen in males is the round type, followed by the oval type with the quadrangular being the least type. In females the predominant type of orbit seen was oval, followed by the quadrangular type, with the round type being the least common. However, the differences were not statistically significant. The round type of orbit shows the strongest tendency in sex identification.
Cartografias do cuidado com mulheres em contextos de violência a partir de um dispositivo clínico-político de saúde mental
Authors: Silva Dipaula Minotto da , Souza Vitória de Oliveira de
Published: September 2023

O presente trabalho trata-se de uma pesquisa-intervenção, que propõe uma cartografia dos processos de subjetivação de mulheres em contextos de violência. O acompanhamento dos processos de cuidado foi oriundo da criação de um dispositivo clínico-político, caracterizado como um grupo de saúde mental com mulheres. O referencial teórico partiu do conceito de gênero e máquina do patriarcado, com o entrelaçamento sobre o campo da saúde mental e atenção psicossocial. Nesse sentido, propus articular o contexto da violência enquanto relacional e analisar os dispositivos de subjetivação, que processualmente constituem as mulheres. A partir da cartografia como método de pesquisa, cheguei a alguns pontos de projeção no mapa, que são as seguintes categorias: o dispositivo materno e a operacionalização da violência institucional; o racismo e o dispositivo amoroso. Tais conceituações ajudaram a compreender o percurso das mulheres em sua constituição subjetiva, bem como tensionar o campo da saúde mental e a propor uma linha de cuidado às mulheres.
Aspectos sociais e culturais envolvidos no processo de transição identitária da população trans
Authors: Medeiros Bianka Andressa de Oliveira , Cavalcante Dafne Ferreira , Fonseca Alvaro Micael Duarte , Belo Rafaella Cristina Tavares , Junior José Antonio da Silva , Nascimento Ellany Gurgel Cosme do
Published: September 2023

A separação entre sexo e gênero, materializada pela noção de identidade de gênero, foi crucial para estabelecer as necessidades das pessoas trans. No entanto, vê-se ainda a influência da matriz cisnormativa. Partindo dessa premissa, esse estudo, enquanto pesquisa qualitativa, teve por objetivo aprofundar o conhecimento e o entendimento dos aspectos individuais, sobretudo, sociais, ligados ao processo de transição identitária deste público, para isso, realizou-se uma pesquisa exploratória e descritiva. Foram entrevistadas 14 pessoas transgêneros residentes no município de Mossoró/RN Encontrou-se 4 categorias de análise: As fortificações da história e do apoio e, direitos básicos perdidos, religião e relacionamentos afetivos. Assim, discutiu-se as consequências da imposição da heteronormatividade e do binarismo de gênero na vida das pessoas transgênero.
[Title erased]
Authors: Gala Vânia
Published: September 2023

[Title Erased]

[Name author Erased]

Abstract

In this paper I describe the collective performance entitled [Titleerased] [reference erased]. The performance was part of the programme [“”], an event on black feminisms. The particular performance(s) performed at [author+title erased] are in this sense rehearsals of the particular positioning of upside down and a web of other various positionings and performances that emerged under this context. The performance assumed the performative conversational form in a long table with the participants. Departing from the idea of positioning as performative or even more mundanely as a position assumed in, with or within black bodies the conversational performance framed questions and speculated about particular positionings.

In this regard, the performative table echoes Glissant’s (2010) sensibility in a belief that things, concepts, ideas do not necessarily follow a transparent deductive course but are often the product of intuitively complex networks in relation. In other respects, these performance(s) reflect a relevant aspect of dance practice. As a praxis – without forgetting its highly oral facet – dance is characterized by “a radical hospitality” towards unfamiliar “languages, unknown processes without evident protocols or contracts” [erased] and in many respects opaque. Opaque to the body, the performers and other various intervenients under choreographic performative processes or trainings.
Treatment of Hydroxyurea-Induced Ulcers With Timolol
Authors: Hwang Angelina S. , Hoss Elika , Pittelkow Mark R. , Yang Yul W.
Published: September 2023

This report evaluates the use of timolol in 2 patients with long-term hydroxyurea use and lower-extremity ulcers resistant to other treatments.
Pain as a Patient-Reported Outcome Measure in Pyoderma Gangrenosum
Authors: Erickson Katherine M. , Kody Shannon , Ortega-Loayza Alex G.
Published: September 2023

This survey study investigates the minimal important difference in pain indicating that a patient with pyoderma gangrenosum may be responding to treatment.
Dermatomyositis in Association With SARS‐CoV‐2 Infection or COVID‐19 Vaccine
Authors: Diaz‐Menindez Maximiliano , Sullivan Megan M. , Wang Benjamin , Majithia Vikas , Abril Andy , Butendieck Ronald R. , Ball Colleen T. , Berianu Florentina
Published: September 2023

Objective

New‐onset and relapsed dermatomyositis (DM) has been reported following SARS‐CoV‐2 infection or COVID‐19 vaccination. This study aims to show the characteristics of a DM cohort after COVID‐19 infection and vaccination.

Methods

A retrospective review was performed on patients treated for DM between March 1, 2020, and October 31, 2022. Charts were evaluated for the presence of new‐onset DM or relapse of preexisting DM following either SARS‐CoV‐2 infection or COVID‐19 vaccination. Data on symptom onset, timing of vaccination, type of vaccination, and disease characteristics were collected.

Results

Ninety‐eight patients treated for DM at our institution in the Division of Rheumatology were included. In total, 12 of 98 patients (12.2%) experienced DM symptoms (either incident or relapse) following either infection or vaccination. Of the 12 patients who developed incident disease or relapse, 7 (58.3%) developed postinfection symptoms, and 8 (66.7%) developed symptoms after vaccination (3 patients had symptoms following both infection and vaccination). The mean onset of symptoms following COVID‐19 infection was 3.2 days (median 0.5 days), and mean onset following COVID‐19 vaccination was 5.75 days (median 3.5 days). Nine of 12 patients (75%) had a positive myositis‐specific antibody, and the remaining 3 (25%) had myositis‐associated antibodies. There was no predominant vaccine associated with the development of postvaccination DM symptoms.

Conclusion

This retrospective review revealed a strong temporal relationship between DM symptoms and COVID‐19 infection or vaccination in 12.2% of all patients with DM evaluated in our clinic during the pandemic. Additional studies are required to understand the possible pathophysiology behind this association.
Upper‐Limb High‐Intensity Interval Training or Passive Heat Therapy to Optimize Cardiorespiratory Fitness Prior to Total Hip or Knee Arthroplasty: A Randomized Controlled Trial
Authors: Roxburgh Brendon H. , Campbell Holly A. , Cotter James D. , Reymann Ulla , Williams Michael J. A. , Gwynne‐Jones David , Thomas Kate N.
Published: September 2023

Objective

Preoperative exercise training, or prehabilitation, aims to optimize cardiorespiratory fitness before surgery to reduce the risk of adverse perioperative events and delayed recovery. However, traditional exercise such as walking and cycling can be difficult for people with degenerative joint diseases of the lower limbs, such as osteoarthritis. The purpose of this study was to compare the effect of three low‐impact interventions on cardiorespiratory fitness, physical function, and subjective health before total hip or knee arthroplasty.

Methods

This was a randomized controlled trial involving 93 participants with severe knee or hip osteoarthritis awaiting joint replacement surgery. Participants underwent cardiopulmonary exercise testing (to measure peak oxygen consumption [O2]), then were randomized to heat therapy (Heat; 20–30 min immersed in 40°C water followed by ~15 min light‐resistance exercise), high‐intensity interval training (HIIT; 6–8 × 60 s intervals on a cross‐trainer or arm ergometer at ~90%–100% peak O2), or home‐based exercise (Home; ~15 min light‐resistance exercise); for up to 36 sessions (3 sessions per week for 12 weeks).

Results

Peak O2 increased by 16% across HIIT and to a greater extent than Heat (+2.5 mL × min−1 × kg−1 [95% CI: 0.5–4.4], P = 0.009) and Home (+3.2 mL × min−1 × kg‐1 [1.2–5.2], P = 0.001). The anaerobic threshold increased across HIIT (+1.5 mL × min−1 × kg−1 [0.7–2.3], P < 0.001) and Heat (+1.2 mL × min−1 × kg−1 [0.4–1.9], P = 0.004), but not Home (−0.5 mL × min−1 × kg−1 [−1.3 to 0.3], P = 0.248). Subjective severity of osteoarthritis was unchanged with any intervention (P ≥ 0.250).

Conclusion

Heat therapy and HIIT improved indices of cardiorespiratory fitness preoperatively in patients who have difficulty performing lower‐limb exercise.

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Amorphization Engineering of Bimetallic Metal‐Organic Frameworks to Identify Volcano‐Type Trend toward Oxygen Evolution Reaction
Authors: Zhou Jian , Qiao Fei , Ren Zhichu , Hou Xianbiao , Chen Zongkun , Dai Shuixing , Su Ge , Cao Zhengwen , Jiang Heqing , Huang Minghua
Published: September 2023

Amorphous metal‐organic frameworks (MOFs) with aperiodic atomic arrangements, featuring high intrinsic activity and rich active sites, have emerged as promising oxygen evolution reaction (OER) catalysts. However, the quantitative structure‐activity relationships (SARs) that determine the OER activity, the key to a rational catalyst design, remain unresolved. Inspired by controllable amorphization engineering, the amorphous MOF structures are rationally constructed as an ideal platform to explore the SAR in catalyzing OER. The mechanistic studies show that the OER activity could be volcano‐shape correlated with either constant adsorption energy difference between OOH* and O* (ΔGOOH* − ΔGO*) or the position of the d band center. The amorphous MOF (Ni8Co2‐BDC), situated close to the volcano summit, possesses an appropriate Ed energy level, which exhibits the balanced intermediates adsorption/desorption ability and consequently results in the boosted catalytic activity and long‐term stability. This work supplies new perspectives to investigate the SAR in amorphous MOF structures, thereby guiding the rational design of advanced OER catalysts.
Inorganic‐Rich Interphase Induced by Boric Oxide Solid Acid toward Long Cyclic Solid‐State Lithium‐Metal Batteries
Authors: Cheng Hang , Cao Junbin , Li Faqiang , Geng Xiaobin , Li Dinggen , Wei Ying , Lin Xing , Xu Henghui , Huang Yunhui
Published: September 2023

Solid‐state electrolytes paired with lithium‐metal anodes is considered a next‐generation energy storage technology. However, the slow ionic transportation of the solid‐state electrolyte and the instability against the lithium‐metal anode impede their practical application. Here a cellulose separator modified with highly uniform boric oxide solid acid, contributing to a high transference number (0.75) and good ionic conductivity of 0.52 mS cm−1 due to the strengthened binding of the salt anions with this solid acid, is reported. Moreover, the boron ions with occupied interstitial sites can release free electrons to regulate the electrochemical dynamics of the electrolyte, in situ inducing the formation of Li2CO3/LiF‐rich heterostructured solid electrolyte interphase layer. The cellulose/B2O3‐based composite electrolyte paired with LiNi0.6Co0.2Mn0.2O2 (NCM622) cathode and Li‐metal anode displays a specific capacity of 155 mAh g−1 with a capacity retention of 92% in 200 cycles. Additionally, this electrolyte paired with high‐mass‐loading NCM622 cathode (10 mg cm−2) in a pouch cell can be stably operated for 50 cycles with a capacity retention of over 90%.
Wet‐Chemical Etching and Delamination of MoAlB into MBene and Its Outstanding Photocatalytic Performance
Authors: Bury Dominika , Jakubczak Michał , Purbayanto Muhammad Abiyyu Kenichi , Rybak Miłosz , Birowska Magdalena , Wójcik Anna , Moszczyńska Dorota , Eisawi Karamullah , Prenger Kaitlyn , Presser Volker , Naguib Michael , Jastrzębska Agnieszka Maria
Published: September 2023

MBenes are post‐MXene materials that contain boron in their structure instead of carbon and nitrogen. This unique composition offers an opportunity to explore the role of boron in the performance of 2D materials. However, wet‐chemical etching and delamination of the starting MoAlB phase are challenging due to the persistent bonding of aluminum atoms with their neighboring elements. Herein, it is overcome by processing MoAlB for 24, 48, and 72 h with an aqueous HCl/H2O2 solution. The time‐wise etching and delamination delivers individual single‐to‐few layered 48‐MBene flakes. The theoretical‐to‐experimental XRD analysis revealed the best‐delaminated 48‐MBene having Mo2B2 orthorhombic lattice arrangement. The presence of Mo oxide allows direct 1.2 eV and indirect 0.2 eV optical band gaps and outstanding photocatalytic activity in decomposing methylene blue as a model organic contaminant. The 48‐MBene photocatalyst achieves about 90% of MB decomposition under ultraviolet and simulated white light irradiation with three times faster kinetics outperforming even hybridized MXenes. In addition, 48‐MBene appeared best suited to utilize the full spectrum of visible light into reactive oxygen species. Conversely, 24‐MBene and 72‐MBene shows incomplete delamination or oxidation, hampering their photocatalytic activity. The obtained results open an experimental pathway to apply MBenes in environmental remediation.
Constructing High‐Performance Solar Cells and Photodetectors with a Doping‐Free Polythiophene Hole Transport Material
Authors: Wu Junjiang , Gao Yuping , Zhou Zhihua , Du Yahui , Liu Junwei , Wang Jingjing , Wang Qian , Zhou Kangkang , Xian Kaihu , Lin Zhenjia , Chen Yu , Zhao Wenchao , Li Sunsun , Kuvondikov Vakhobjon , Yin Hang , Yan Jinyue , Liu Yongsheng , Ye Long
Published: September 2023

The emerging solution‐based solar cells and photodetectors have gained worldwide research interest over the past decades. Hole transport materials (HTMs) have greatly advanced the progress of these solution‐based electronics. Nevertheless, developing low‐cost and efficient HTMs is far from satisfactory. In this contribution, poly(3‐pentylthiophene) (P3PT) is introduced as a facile, low‐cost, and versatile dopant‐free polymer HTM for both quantum dot (QD) and perovskite electronic devices. Compared to the broadly used poly(3‐hexylthiophene), P3PT presents the reduced molecular aggregation and preferential face‐on orientation, which can markedly enhance the hole‐carrier transport in optoelectronic devices. Accordingly, P3PT can deliver the substantial improvement of photovoltaic performance from ∼8.6% to ∼9.5% for QD/polythiophene solar cells and from ∼16% to ∼18.8% for perovskite/polythiophene solar cells, which are both among the topmost values in the corresponding fields. Furthermore, P3PT HTMs can also significantly enhance the photodetection performance of QD and perovskite photodetectors by a factor of ∼3, indicating its great application potential in a variety of emerging optoelectronics.
Enhanced Thermal Stability of Red‐Emitting Sr2Si5N8:Eu2+ Phosphors from Triggered Applicable Trap Level via Rare Earth Ions Co‐Doping
Authors: Li Zebin , Seto Takatoshi , Wang Yuhua
Published: September 2023

To solve the problem of thermal stability of the red‐emitting phosphor Sr2Si5N8:Eu2+ with great valuable luminescence performance, trivalent rare earth ions Ln3+ (Ln = Dy, Ho, Er, Tm, Nd, and Pr) are co‐doped into Sr2Si5N8: Eu2+ lattice to form thermally robust phosphors Sr2Si5N8:Eu2+,xLn3+(Lnx‐258, 0 ≤ x ≤ 0.05). The successful incorporation of rare earth ions in the crystal structure and the regulation of luminescent properties are proven by a variety of material characterization techniques and analysis. Although the co‐doping of the selected rare earth ions reduces the luminescence intensity of the phosphor, the Dy0.01‐258 sample still has a high external quantum efficiency (EQE) of 78.6%. More importantly, the co‐doping of Dy3+ with x = 0.01 significantly improves the luminescent thermal stability of phosphors at high temperature and the luminescence intensity of Dy0.01‐258 samples at 200 °C can be maintained at 94.7% of room temperature. The thermoluminescence spectrum shows that the defects brought about by co‐doping of Dy3+ with x = 0.01 introduce trap energy levels, which can compensate for the Eu2+ luminescence at high temperature. At the same time, the cathodoluminescence mapping and spectra show that the phosphor has a high saturation current under high‐energy electron bombardment, which indicates that this nitride phosphor also has the potential to be used in field emission display (FEDs). Based on its extraordinary EQE and thermal stability data, this nitride phosphor is the first‐rate among the red phosphors for pc‐wLEDs, and has excellent application prospects in FEDs.
Mild Photothermal Therapy Prevents Posterior Capsule Opacification through Cytoskeletal Remodeling
Authors: Lin Lei , Xu Liming , Sun Weijie , Liang Lili , Qi Xiaoliang , Zhao Yun‐e
Published: September 2023

Cataract is the first leading cause of blindness in the world and posterior capsule opacification (PCO) is the most common long‐term complication after surgery. The primary pathogenic processes contributing to PCO are the proliferation and migration of residual lens epithelial cells (LECs). This study aimed to explore the mild photothermal effect on LECs. Interestingly, this work finds that the mild photothermal effect significantly inhibited the proliferation and migration of LECs. The live cell fluorescence imaging reveals that the remodeling of the actin cytoskeleton and cell morphology attributed to the inhibition effect. Further mechanistic studies at molecular level suggest that the mild photothermal effect can regulate the phosphorylation of ERM, YAP, and Cofilin and thereby affect the proliferation and migration of LECs. In order to explore the potential clinical application of mild photothermal therapy for PCO prevention, PDA/PVA gel rings with photothermal effect is prepared by the repeated freeze‐thaw method and conducted experiments in vivo, which achieved favorable PCO prevention effect. Overall, this study shows that the mild photothermal effect can regulate the proliferation and migration of LECs through cytoskeletal remodeling and the results of experiments in vivo demonstrate that mild photothermal effect is a promising approach for PCO prevention.
Illuminating the Brain: Advances and Perspectives in Optoelectronics for Neural Activity Monitoring and Modulation
Authors: Xu Shumao , Momin Marzia , Ahmed Salahuddin , Hossain Arafat , Veeramuthu Loganathan , Pandiyan Archana , Kuo Chi‐Ching , Zhou Tao
Published: September 2023

Optogenetic modulation of brain neural activity that combines optical and electrical modes in a unitary neural system has recently gained robust momentum. Controlling illumination spatial coverage, designing light‐activated modulators, and developing wireless light delivery and data transmission are crucial for maximizing the use of optical neuromodulation. To this end, biocompatible electrodes with enhanced optoelectrical performance, device integration for multiplexed addressing, wireless transmission, and multimodal operation in soft systems have been developed. This review provides an outlook for uniformly illuminating large brain areas while spatiotemporally imaging the neural responses upon optoelectrical stimulation with little artifacts. Representative concepts and important breakthroughs, such as head‐mounted illumination, multiple implanted optical fibers, and micro‐light‐delivery devices, are discussed. Examples of techniques that incorporate electrophysiological monitoring and optoelectrical stimulation are presented. Challenges and perspectives are posed for further research efforts toward high‐density optoelectrical neural interface modulation, with the potential for nonpharmacological neurological disease treatments and wireless optoelectrical stimulation.