bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphometric analysis of the Late CretaceousPlacenticerasof Alabama, USA: sexual dimorphism, allometry, and implications for taxonomy
Authors: Mohr Rachel C. , Tobin Thomas S. , Tompkins Emily M.
Published: May 2024

A traditional typological approach to taxonomy often does not adequately account for intraspecific variation and can result in taxonomic oversplitting. For many groups, including ammonoids of thePlacenticerasgenus, intraspecific variation documented in recent studies (e.g., ontogenetic changes, sexual dimorphism, polymorphism) challenges the historic proliferation of species names. Here, we used a population approach to taxonomy and quantitatively evaluated morphometric variation in a sample of Late Cretaceous (Santonian–Campanian)Placenticerasfrom Alabama and adjacent counties.

We used linear mixed models (LMMs) to characterize how morphological variables scale with conch size across the sample, exploiting mixed longitudinal data to evaluate individual variation in growth and inform interpretations of multivariate analyses. Extended LMMs incorporating geological formation evaluated morphological changes through time. Principal component analysis and clustering analysis were then used to evaluate the number of distinct clusters that emerged in multivariate morphospace independent of previous taxon name assignments.

Discontinuous scaling relationships and distinct clusters in multivariate space suggest sexual dimorphism characterized by differences in adult size and, secondarily, shape. PreviousStantonocerasandPlacenticerasassignments broadly overlap in our morphospace, failing to justify this historic distinction (as sexual dimorphs or as genera or subgenera).Placenticerasconch morphology and ornament placement changed through time, suggesting a potential utility for coarse (stage-level) biostratigraphy. However, temporal changes were not associated with distinct clusters in morphospace, and our data fail to support the plethora of reported species names. As few as one or two (successive) species may be present in our sample (representing 130 years of collection effort). In addition to highlighting the need for a significant taxonomic revision of thePlacenticerasgenus, this study demonstrates the utility of LMMs for distinguishing between different sources of morphological variation, improving interpretations of morphospace under a population approach to taxonomy, and maximizing the amount of ontogenetic information that can be obtained nondestructively.
The evolution of femoral morphology in giant non-avian theropod dinosaurs
Authors: Pintore Romain , Hutchinson John R. , Bishop Peter J. , Tsai Henry P. , Houssaye Alexandra
Published: May 2024

Theropods are obligate bipedal dinosaurs that appeared 230 Ma and are still extant as birds. Their history is characterized by extreme variations in body mass, with gigantism evolving convergently between many lineages. However, no quantification of hindlimb functional morphology has shown whether these body mass increases led to similar specializations between distinct lineages. Here we studied femoral shape variation across 41 species of theropods (n = 68 specimens) using a high-density 3D geometric morphometric approach. We demonstrated that the heaviest theropods evolved wider epiphyses and a more distally located fourth trochanter, as previously demonstrated in early archosaurs, along with an upturned femoral head and a mediodistal crest that extended proximally along the shaft. Phylogenetically informed analyses highlighted that these traits evolved convergently within six major theropod lineages, regardless of their maximum body mass. Conversely, the most gracile femora were distinct from the rest of the dataset, which we interpret as a femoral specialization to “miniaturization” evolving close to Avialae (bird lineage). Our results support a gradual evolution of known “avian” features, such as the fusion between lesser and greater trochanters and a reduction of the epiphyseal offset, independent from body mass variations, which may relate to a more “avian” type of locomotion (more knee than hip driven). The distinction between body mass variations and a more “avian” locomotion is represented by a decoupling in the mediodistal crest morphology, whose biomechanical nature should be studied to better understand the importance of its functional role in gigantism, miniaturization, and higher parasagittal abilities.
The Weston Park Music Collection: Five Generations of Family Music-Making in Eighteenth-Century Staffordshire
Authors: Perkins Martin
Published: May 2024

The activities of eighteenth- and nineteenth-century music collectors help to chart the development of the period’s canon and understand the connections between consumers as amateur musicians and collectors and the composers and their music. In 2014, a collection of music came to light at the ancestral seat of the Earls of Bradford, Weston Park in Shropshire, which reveals a scenario of amateur music-making intrinsically linked to the wider professional scene. This collection has been largely ignored due to its unbound state in a private residence. It is of importance for its association with the five generations of the Bridgeman family, and for numerous manuscripts of previously unknown cello works; but crucially, the presence of four manuscript catalogues, a teacher’s bill for music, and an auction sale catalogue dating from the time, helps to fill in the gaps of what was being performed in the house, by whom, where, and when. This article describes seven sources connected with family music-making and presents a catalogue of the current music collection at Weston Park as supplementary material in the form of a data set in an Excel spreadsheet. Readers can consult the collection as it stands today and how it developed over 150 years.
A Return to Khaki Rule? Democracy and Africa's Lost History of Military Government
Authors: Mann Gregory
Published: May 2024

Much of West Africa (and particularly the Sahel) may be once falling again under military government. This essay asks what, if anything, historians of Africa can contribute to an understanding of this phenomenon. I argue that writing the history and understanding the memory of military government will entail a renewed approach to political history and social theory. It will also entail confronting — just as so many citizens are currently doing — the peculiar failures of democracy in Africa's neoliberal era.
Development of a disease-specific health utility score for chronic obstructive pulmonary disease from a discrete choice experiment patient preference study
Authors: Jones Byron , Ryan Mandy , Cook Nigel S. , Gutzwiller Florian S.
Published: May 2024

Objectives

While patient input to health technology assessment (HTA) has traditionally been of a qualitative nature, there is increasing interest to integrate quantitative evidence from patient preference studies into HTA decision making. Preference data can be used to generate disease-specific health utility data. We generated a health utility score for patients with chronic obstructive pulmonary disease (COPD) and consider its use within HTAs.

Methods

Based on qualitative research, six symptoms were identified as important to COPD patients: shortness of breath, exacerbations, chronic cough, mucus secretion, sleep disturbance, and urinary incontinence. We employed a discrete choice experiment (DCE) and the random parameter logistic regression technique to estimate utility scores for all COPD health states. The relationship between patients’ COPD health utility scores, self-perceived COPD severity, and EQ-5D-3L utility scores was analyzed, with data stratified according to disease severity and comorbidity subgroups.

Results

The COPD health utility score had face validity, with utility scores negatively correlated with patients’ self-perceived COPD severity. The correlation between the COPD health utility scores and EQ-5D-3L values was only moderate. While patient EQ-5D-3L scores were impacted by comorbidities, the COPD health utility score was less impacted by comorbid conditions.

Conclusions

Our COPD utility measure, derived from a DCE, provides a patient-centered health utility score and is more sensitive to the COPD health of the individual and less sensitive to other comorbidities. This disease-specific instrument should be considered alongside generic health-related quality of life instruments when valuing new COPD therapies in submissions to licensing and reimbursement agencies.
The Impact of Alcohol-Related Presentations to Emergency Departments on Days with a Public Holiday or Sporting Event: A Retrospective Cohort Study
Authors: Hagan Stephanie Rae , Crilly Julia , Ranse Jamie
Published: May 2024

Introduction:

The consumption of alcohol within the Australian community continues to rise, impacting care delivery in already over-burdened emergency departments (EDs).

Study Objective:

This study aimed to examine the impact of alcohol-related presentations (ARPs) to EDs on days with a public holiday or sporting event.

Methods:

A retrospective cohort study was undertaken using routinely collected health data pertaining to patient presentations diagnosed with an alcohol-related disorder (ICD-10-AM code F10) to two EDs in Queensland, Australia from January 1, 2016 – December 31, 2020. Descriptive and inferential statistics were used to describe and compare ARPs on event days versus non-event days and uncomplicated versus other ARPs on event days only.

Results:

Of all 5,792 ARPs, nine percent (n = 529) occurred on public holidays or sporting event days. When compared by day type, type of presentation, mode of arrival, and day of week differed between event and non-event days. On event days, uncomplicated ARPs differed to other ARPs, with uncomplicated ARPs being younger, having shorter median length-of-stay (LOS), and less likely to be admitted to hospital.

Conclusions:

In this multi-site study, public holidays and sporting events had a noteworthy impact on ARPs to EDs. Focused refinement on the clinical management of uncomplicated ARPs is warranted to inform future resource allocation, including on event days.
Is the Hamilton regression filter really superior to Hodrick–Prescott detrending?
Authors: Franke Reiner , Kukacka Jiri , Sacht Stephen
Published: May 2024

An article published in 2018 by J.D. Hamilton gained significant attention due to its provocative title, “Why you should never use the Hodrick-Prescott filter.” Additionally, an alternative method for detrending, the Hamilton regression filter (HRF), was introduced. His work was frequently interpreted as a proposal to substitute the Hodrick–Prescott (HP) filter with HRF, therefore utilizing and understanding it similarly as HP detrending. This research disputes this perspective, particularly in relation to quarterly business cycle data on aggregate output. Focusing on economic fluctuations in the United States, this study generates a large amount of artificial data that follow a known pattern and include both a trend and cyclical component. The objective is to assess the effectiveness of a certain detrending approach in accurately identifying the real decomposition of the data. In addition to the standard HP smoothing parameter of

$\lambda = 1600$

, the study also examines values of

$\lambda ^{\star }$

from earlier research that are seven to twelve times greater. Based on three unique statistical measures of the discrepancy between the estimated and real trends, it is evident that both versions of HP significantly surpass those of HRF. Additionally, HP with

$\lambda ^{\star }$

consistently outperforms HP-1600.
Assessing Drifting Fish Aggregating Device (dFAD) Abandonment under International Marine Pollution Law
Authors: Schatz Valentin
Published: May 2024

This article asks whether the abandonment of drifting fish aggregating devices (dFADs) is illegal under international marine pollution law. To answer this question, it provides a brief overview of the general international legal framework for the protection of the marine environment as well as specific legal regimes, namely the London Convention on the Prevention of Marine Pollution by Dumping of Wastes and Other Matter (LC), its 1996 Protocol (LP), and Annex V of the International Convention for the Prevention of Pollution from Ships (MARPOL). The article concludes that the abandonment of dFADs contravenes the LC/LP and/or, depending on the preferred interpretation, MARPOL Annex V. The decision as to which of the two regimes is applicable depends on whether dFAD abandonment can be classified as ‘incidental to, or derived from the normal operations of vessels … and their equipment’ or not. The negligent loss of dFADs always violates MARPOL Annex V. The article also shows that certain state practice andopinio jurissuggests a parallel applicability of the two regimes with respect to deliberate dFAD abandonment. While such a development would ensure more comprehensive coverage of the relevant standards and prohibitions, a clear regulatory decision as to which of the two regimes is the correct one would be preferable from an implementation and enforcement perspective.
Quantifying the Value of Technology and Policy Innovation in Water Resource Portfolios
Authors: Zaniolo Marta , Fletcher Sarah , Mauter Meagan S.
Published: May 2024

Recent water infrastructure planning models demonstrate that explicitly accounting for hydrological changes in long‐term water planning reduces costs and increases system robustness. However, current models do not consider the effects of other changes occurring in the system over long time horizons, namely technology and policy innovation. By leveraging state‐of‐the‐art dynamic control techniques, we propose a suite of tools that explicitly relate hydrologic change, technology innovation, and policy interventions to system‐level water costs. We design robust and cost‐optimal strategies for water supply expansion under hydrological variability and hundreds of plausible innovation states, for example, treatment cost and diversification improvements, deployment times, and demand reduction campaigns. Our approach circumvents the need to pre‐assign probabilities to innovation scenarios and, instead, directly calculates the effects of technology, policy, and hydrology variations on system cost and planning strategies to identify avenues of impactful innovation. These tools can support technology development hubs, urban, state, and federal water planners in anticipating cost implications of technology and policy innovation at the local level, and prioritizing high‐impact innovation goals based on quantitative targets. Results for the case study of Santa Barbara, California identify high‐value innovation attributes for the city as well as combinations of innovation attributes across technologies and policies, and quantify their potential utility cost reductions.
A Global Increase in Nearshore Tropical Cyclone Intensification
Authors: Balaguru Karthik , Chang Chuan‐Chieh , Leung L. Ruby , Foltz Gregory R. , Hagos Samson M. , Wehner Michael F. , Kossin James P. , Ting Mingfang , Xu Wenwei
Published: May 2024

Tropical Cyclones (TCs) inflict substantial coastal damages, making it pertinent to understand changing storm characteristics in the important nearshore region. Past work examined several aspects of TCs relevant for impacts in coastal regions. However, few studies explored nearshore storm intensification and its response to climate change at the global scale. Here, we address this using a suite of observations and numerical model simulations. Over the historical period 1979–2020, observations reveal a global mean TC intensification rate increase of about 3 kt per 24‐hr in regions close to the coast. Analysis of the observed large‐scale environment shows that stronger decreases in vertical wind shear and larger increases in relative humidity relative to the open oceans are responsible. Further, high‐resolution climate model simulations suggest that nearshore TC intensification will continue to rise under global warming. Idealized numerical experiments with an intermediate complexity model reveal that decreasing shear near coastlines, driven by amplified warming in the upper troposphere and changes in heating patterns, is the major pathway for these projected increases in nearshore TC intensification.
Assessing the Risk of Potential Tsunamigenic Earthquakes in the Mentawai Region by Seismic Imaging, Central Sumatra
Authors: Qin Yanfang , Chen Jian , Singh Satish C. , Hananto Nugroho , Carton Helene , Tapponnier Paul
Published: May 2024

In the marginal regions along subduction zones, oceanic plates subducting beneath continental plates produce the largest number of earthquakes on Earth and sometimes devastating tsunamis. The lateral segmentation of earthquakes along the Sumatra subduction zone is well documented. However, the entirely different seismic behaviors among the segments indicate that local structures are key elements controlling coseismic slip propagation; in particular, frontal accretionary prism structures are closely associated with tsunami generation. Offshore of Central Sumatra, in the Mentawai segment, large earthquakes nucleated in 2007 and 2010 caused many human casualties and a great deal of property loss. Using seismic reflection data, we show the subsurface structure of accretionary over a significant portion of the frontal wedge that did not rupture during the 2007 earthquake, and this area remains locked. The subsurface deformation structure at the wedge front, which is similar to that in the 2010 Mw7.8 tsunami earthquake rupture zone, suggests the potential for a large tsunami earthquake in the near future. On the other hand, the along‐strike variations of the effective basal friction at shallow depth may indicate that different coseismic behaviors are caused by a sudden failure of the deeper seismogenic zone.
Local Magnetic Anomalies Explain Bias in Paleomagnetic Data: Consequences for Sampling
Authors: Meyer Romy , de Groot Lennart V.
Published: May 2024

Volcanic rocks are considered reliable recorders of past changes in the Earth's magnetic field. Recent flows, however, sometimes fail to produce the known magnetic field at the time of cooling. Previous research on Mt. Etna suggests paleomagnetic data might not be accurately recorded. Here we test the accuracy of paleomagnetic data obtained from Mt. Etna lavas by comparing paleomagnetic data from historical flows to direct measurements of the magnetic field above the current topography. The inclinations and intensities in both data sets are biased toward lower values, while there is no such trend for the declination. Inclinations are on average 2.9° lower than expected; intensities are on average 8.8 µT lower. The deviations from the expected values depend on the height above the flow. Moreover, the inclinations and intensities vary as a function of topography. Both are higher above ridges and lower in gullies; the variations within a site are up to 14.1° in inclination and 12.9 µT for intensity. To suppress this paleomagnetic data bias it is important to take samples several meters apart and from different parts of the flow whenever possible. While this leads to a higher degree of scatter in paleodirections, the results better represent the Earth's magnetic field at the time of cooling. This emphasizes the importance of reporting paleomagnetic sampling strategies in detail.
Increasing Fire Activity in African Tropical Forests Is Associated With Deforestation and Climate Change
Authors: Wimberly M. C. , Wanyama D. , Doughty R. , Peiro H. , Crowell S.
Published: May 2024

Fires were historically rare in tropical forests of West and Central Africa, where dense vegetation, rapid decomposition, and high moisture limit available fuels. However, increasing heat and drought combined with forest degradation and fragmentation are making these areas more susceptible to wildfires. We evaluated historical patterns of Moderate Resolution Imaging Spectroradiometer active fires in African tropical forests from 2003 to 2021. Trends were mostly positive, particularly in the northeastern and southern Congo Basin, and were concentrated in areas with high deforestation. Year‐to‐year variation of fires was synchronized with increasing temperature and vapor pressure deficit. There was anomalously high fire activity across the region during the 2015–2016 El Niño. These results contrast with the drier African woodlands and savannas, where fire has been decreasing. Further attention to fires in African tropical forests is needed to understand their global impacts on carbon dynamics and their local implications for biodiversity and human livelihoods.
Relativistic Electron Precipitation Events Driven by Solar Wind Impact on the Earth's Magnetosphere
Authors: Roosnovo Alexandra , Artemyev Anton V. , Zhang Xiao‐Jia , Angelopoulos Vassilis , Ma Qianli , Grimmich Niklas , Plaschke Ferdinand , Fischer David , Werner Magnes
Published: May 2024

Certain forms of solar wind transients contain significant enhancements of dynamic pressure and may effectively drive magnetosphere dynamics, including substorms and storms. An integral element of such driving is the generation of a wide range of electromagnetic waves within the inner magnetosphere, either by compressionally heated plasma or by substorm plasma sheet injections. Consequently, solar wind transient impacts are traditionally associated with energetic electron scattering and losses into the atmosphere by electromagnetic waves. In this study, we show the first direct measurements of two such transient‐driven precipitation events as measured by the low‐altitude Electron Losses and Fields Investigation CubeSats. The first event demonstrates storm‐time generated electromagnetic ion cyclotron waves efficiently precipitating sub‐relativistic and relativistic electrons from >300 keV to 2 MeV at the duskside. The second event demonstrates whistler‐mode waves leading to scattering of electrons from 50 to 700 keV on the dawnside. These observations confirm the importance of solar wind transients in driving energetic electron losses and subsequent dynamics in the ionosphere.
Effects of an Intrinsic Magnetic Field on Ion Escape From Ancient Mars Based on MAESTRO Multifluid MHD Simulations
Authors: Sakata R. , Seki K. , Terada N. , Sakai S. , Shinagawa H.
Published: May 2024

Ion escape has played a key role in atmospheric loss on ancient Mars due to intense solar activity. Under the existence of a strong global intrinsic magnetic field, as expected on ancient Mars, differential flows between different ion species can be important for ion escape. To assess effects of differential flows, we here developed a new global multifluid magnetohydrodynamics model with a cubed sphere grid named Multifluid Atmospheric Escape Simulations Toward Real elucidatiOn (MAESTRO). A test simulation under present‐day Mars conditions showed solar wind‐Mars interactions, for example, plasma boundaries, ionospheric profiles, and tailward outflows, consistent with observations and simulation studies. We then conducted multifluid and multispecies simulations with six different dipole field strengths under ancient Mars conditions. The multifluid cases show asymmetric outflow distributions with respect to the solar wind convection electric field, as pointed out by previous studies on present‐day Mars. Compared with multispecies cases, the multifluid representation increases the escape rates of O2+ and CO2+ by more than two orders of magnitude in the strong dipole field cases where the cusp outflow is dominant. The O+ escape rate is slightly lower in the multifluid cases with no or weak dipole field due to suppression of ion pickup in the −E hemisphere, while it is reduced by one order of magnitude in the strongest dipole field case. The existence of a dipole field can reduce the total escape rate by a factor of six. The impact on atmospheric evolution is diminished but still significant.
Reassessment of Birch's Law on hcp‐Fe From Ultrasonic Sound Velocity Measurement and Implications on the Velocity Profiles of Earth's Inner Core
Authors: Wang Siheng , Chen Sibo , Qi Xintong , Xu Man , Yu Tony , Wang Yanbin , Li Baosheng
Published: May 2024

We performed in situ X‐ray diffraction and ultrasonic sound velocity measurements on hcp‐Fe up to 15 GPa, 873 K in a multi‐anvil apparatus. The elastic moduli and their pressure and temperature derivatives were determined by fitting the velocity and density data to the third‐order finite strain equations, yielding KS0 = 169.0(57) GPa, KS0′ = 5.4(6), (∂KS/∂T)P = −0.031(3) GPa/K, G0 = 104.5(27) GPa, G0′ = 1.7(2), (∂G/∂T)P = −0.060(2) GPa/K. Within the experimental P‐T range, we find significant temperature effect on the density‐velocity (ρ − VP or S) relations and caution the use of the temperature‐independent Birch's law for extrapolation to core conditions. Furthermore, temperature‐induced velocity decrease is more significant in VS than in VP, offering a possible explanation for the high Poisson's ratio in the core. Extrapolations based on our results together with previous experimental data suggest that VP of hcp‐Fe aligns with PREM at Earth's core conditions, while Vs and density are approximately 10% and 2.7% higher than PREM, respectively.
Viscosity Measurements at High Pressures: A Critical Appraisal of Corrections to Stokes' Law
Authors: Ashley Aaron Wolfgang , Mookherjee Mainak , Xu Man , Yu Tony , Manthilake Geeth , Wang Yanbin
Published: May 2024

Fluids and melts in planetary interiors significantly influence geodynamic processes from volcanism to global‐scale differentiation. The roles of these geofluids depend on their viscosities (η). Constraining geofluid η at relevant pressures and temperatures relies on laboratory‐based measurements and is most widely done using Stokes' Law viscometry with falling spheres. Yet small sample chambers required by high‐pressure experiments introduce significant drag on the spheres. Several correction schemes are available for Stokes' Law but there is no consensus on the best scheme(s) for high‐pressure experiments. We completed high‐pressure experiments to test the effects of (a) the relative size of the sphere diameter to the chamber diameter and (b) the top and bottom of the chamber, that is, the ends, on the sphere velocities. We examined the influence of current correction schemes on the estimated viscosity using Monte Carlo simulations. We also compared previous viscometry work on various geofluids in different experimental setups/geometries. We find the common schemes for Stokes' Law produce statistically distinct values of η. When inertia of the sphere is negligible, the most appropriate scheme may be the Faxén correction for the chamber walls. Correction for drag due to the chamber ends depends on the precision in the sinking distance and may be ineffective with decreasing sphere size. Combining the wall and end corrections may overcorrect η. We also suggest the uncertainty in η is best captured by the correction rather than propagated errors from experimental parameters. We develop an overlying view of Stokes' Law viscometry at high pressures.
Parameterization of Shear‐To‐Strain Ratio Used in Finescale Parameterization
Authors: Sun H. , Yang Q. , Li J. , Zhao W. , Tian J.
Published: May 2024

The Gregg‐Henyey‐Polzin (GHP) finescale parameterization is widely employed to infer turbulent mixing when microstructure measurements are unavailable. However, the strain‐only GHP scaling is the only option when shear information is lacking, in which case the shear‐to‐strain ratio (Rω) is commonly treated as a constant. Since Rω has been reported to vary spatiotemporally, using a fixed value of Rω might result in a significant bias in inferring turbulent mixing. In this study, we present a global map of Rω, based on the microstructure database contributed by the Climate Process Team on internal wave‐driven ocean mixing, which covers the Indian, Pacific, and Atlantic oceans across both high and low latitudes. Then, we propose a parameterization of Rω by considering buoyancy frequency, Coriolis frequency, and topographic features. Compared to the GHP scaling with constant Rω, the turbulent dissipation rate values inferred from the GHP scaling with parameterized Rω are more accurate. In this manner, this study provides a reference for choosing optimal Rω when using the strain‐only GHP scaling to explore turbulent mixing in the open ocean.
On the Mechanisms Driving Latent Heat Flux Variations in the Northwest Tropical Atlantic
Authors: Fernández Pablo , Speich Sabrina , Bellenger Hugo , Lange Vega Diego , Karstensen Johannes , Zhang Dongxiao , Rocha Cesar Barbedo
Published: May 2024

The Northwest Tropical Atlantic (NWTA) is a region of complex surface ocean circulation. The most prominent feature is the North Brazil Current (NBC) and its retroflection at 8°N, which leads to the formation of numerous mesoscale eddies known as NBC rings. The NWTA also receives the outflow of the Amazon River, generating freshwater plumes that can extend up to 100,000 km2. We show that these two processes influence the spatial variability of the region's surface latent heat flux (LHF). On the one hand, the presence of surface freshwater modifies the vertical stratification of the ocean, the mixed layer heat budget, and thus the air‐sea heat exchanges. On the other hand, NBC rings create a highly heterogeneous mesoscale sea surface temperature (SST) field that directly influences the near‐surface atmospheric circulation. These effects are illustrated by observations from the ElUcidating the RolE of Cloud‐Circulation Coupling in ClimAte ‐ Ocean Atmosphere (EUREC4A‐OA) and Atlantic Tradewind Ocean‐Atmosphere Interaction Campaign (ATOMIC) experiments, satellite and reanalysis data. We decompose the LHF budget into several terms controlled by different atmospheric and oceanic processes to identify the mechanisms leading to LHF changes. We find LHF variations of up to 160 W m2, of which 100 W m2 are associated with wind speed changes and 40 W m2 with SST variations. Surface currents or heat release associated with stratification changes remain as second‐order contributions with LHF variations of less than 10 W m2 each. This study highlights the importance of considering these three components to properly characterize LHF variability at different spatial scales, although it is limited by the scarcity of collocated observations.
Possible Maximum Earthquake Tsunami Along the South Coast of China Inferred From GPS‐Derived Surface Velocities
Authors: Zhao G. , Niu X.
Published: May 2024

This study aims to assess the tsunami hazard of the maximum possible earthquake along the south coast of China. GPS‐derived surface velocities around the Manila Trench have been used to clarify the active tectonics and estimate the seismic potential of Manila subduction, where catastrophic tsunamis may originate and cause devastating damage to the surrounding area of the South China Sea. Based on the maximum potential earthquake magnitude estimated from the accumulated seismic moment, more than 100,000 possible tsunami scenarios with varying epicenters have been simulated considering the slip heterogeneity. The impact of several uncertain parameters including the release period and release ratio of accumulated seismic moment are investigated, as well as some assumptions in the model of tsunami generation. Although different release conditions for accumulated seismic moment result in a significant impact on the value of tsunami height, similar trend in spatial distribution has been shown. The results show that the tsunami wave height along the south coast of China has an increasing trend from west to east, with the maximum tsunami wave height exceeding 10 m corresponding to the potential earthquake Mw = 9.1 with a 1,000‐year release period. The impact of fault slip heterogeneity on tsunami wave height is significant. Compared to uniform slip, considering stochastic slip will increase the average tsunami wave height by about 15%. Considering locking distribution will increase the average tsunami wave height by about 20%–30% and also increase the maximum tsunami wave height by about 60%–70%.
Spatial and Temporal Patterns in Observed Extreme Precipitation Change Over Northern Part of the Korean Peninsula
Authors: Om Kum‐Chol , Ren Guoyu , Jong Sang‐Il , Ham Yong‐Sik , Hong Chang‐Won , Kang‐Chol O. , Tysa Suonam Kealdrup
Published: May 2024

The present study aims to detect the variation of precipitation extreme events in the northern part of the Korean Peninsula during 1961–2020, as well as to investigate its possible causes, based on daily precipitation data from 37 representative stations. Nonparametric tests such as Mann‐Kendall and Kendall‐tau were used to detect statistical characteristics of changes in precipitation indices and climate variables. Findings are as follows: (a) the annual total precipitation manifested a clear shifting point in 1968, with a decreasing rate of about −37.7 mm/decade, conversely, daily precipitation intensity had a clear upward trend, and extreme precipitation events above 100 mm/day became more frequent. (b) There occurred significant upward trends of 8.9 mm/decade for intense rainfall (>95th percentile) and 6.3 mm/decade for extreme intense rainfall (>99th percentile). (c) The continuous wet (dry) days showed a decreasing (increasing) trend of about −0.2 days/decade (1.0 days/decade). The decrease rate of 5‐day max precipitation is five times as large as 1‐day max precipitation. (d) For June‐September, the strengthened West Pacific Subtropical High intensity and the variation of its ridge‐axis position, the southerly shift of the upper subtropical Jetstream and the weakening of lower moisture supplement may have suppressed the northerly move of the summer rain band and delayed the development of rainy season over the study area. (e) In view of the urbanization effect, the possible causes of the precipitation externalization were investigated, and it was found that the upward trends in daily precipitation intensity and 95th percentile intense precipitation in big cities are generally higher than rural regions.
Reconciling Mars InSight Results, Geoid, and Melt Evolution With 3D Spherical Models of Convection
Authors: Murphy J. P. , King S. D.
Published: May 2024

We investigate the geodynamic and melting history of Mars using 3D spherical shell models of mantle convection, constrained by the recent InSight mission results. The Martian mantle must have produced sufficient melt to emplace the Tharsis rise by the end of the Noachian–requiring on the order of 1–3 × 109 km3 of melt after accounting for limited (∼10%) melt extraction. Thereafter, melting declined; however, abundant evidence for limited geologically recent volcanism necessitates some present‐day melt even in the cool mantle inferred from InSight data. We test models with two mantle activation energies and a range of crustal Heat Producing Element (HPE) enrichment factors and initial core‐mantle boundary temperatures. We also test the effect of including a hemispheric (spherical harmonic degree‐1) step in lithospheric thickness to model the Martian dichotomy. We find that a higher activation energy (350 kJ mol−1) rheology produces present‐day geotherms consistent with InSight results, and crustal HPE enrichment factors of 5–10‐times produce localized melting near or up to present‐day. The 10‐times crustal HPE enrichment is consistent with both InSight and geochemical results and also produces present‐day geoid power spectra consistent with Mars. However, calculations that match the present‐day geoid power spectra require more than 60% melt extraction to produce the Tharsis swell. The addition of a degree‐1 hemispheric dichotomy, as an equatorial step in lithospheric thickness, does not significantly improve upon melt production or the geoid.
Treatment of newly diagnosed moderate or severe chronic graft-versus-host disease with prednisone and everolimus (PredEver first): a prospective multicenter phase IIA study
Authors: Ayuk Francis , Wagner-Drouet Eva-Maria , Wolff Daniel , von Huenerbein Natascha , von Pein Ute-Marie , Klyuchnikov Evgeny , von Harsdorf Stephanie , Koenecke Christian , Sayer Herbert , Kröger Nicolaus
Published: May 2024

Although most patients with chronic graft-versus-host disease (cGVHD) show initial response to first-line therapy, long-term clinically meaningful success of first-line treatment remains rare. In a prospective multicentre phase II trial in 6 German centers, patients with newly diagnosed moderate or severe cGVHD received prednisone and everolimus for 12 months followed by a 1-year follow-up period. Primary endpoint was treatment success (TS) at 6 months defined as patient being alive, achieving PR or CR of cGVHD, having no relapse of underlying disease and requiring no secondary treatment for cGVHD. Of the 34 patients evaluable for efficacy, 19 (56%) had TS at 6 months with 22 and 52% of the patients in a CR and PR respectively. Overall 30 patients (88%) had a CR or PR as best response, nearly all responses (29/30) occurring within the first 6 weeks of treatment. The cumulative incidence of treatment failure at 1 year was 63%, corresponding to 37% TS. Predefined safety endpoint (thrombotic microangiopathy, pneumonitis, and avascular necrosis) were not observed in any patient. Addition of everolimus to prednisolone is well tolerated and may improve long-term treatment success. Larger studies are necessary to ascertain the possible role of everolimus in first-line treatment of cGVHD.
Differential contribution for ERK1 and ERK2 kinases in BRAFV600E-triggered phenotypes in adult mouse models
Authors: Bosso Giuseppe , Cintra Herpst Ana Carolina , Laguía Oscar , Adetchessi Sarah , Serrano Rosa , Blasco Maria A.
Published: May 2024

The BRAF gene is mutated in a plethora of human cancers. The majority of such molecular lesions result in the expression of a constitutively active BRAF variant (BRAFV600E) which continuously bolsters cell proliferation. Although we recently addressed the early effects triggered by BRAFV600E-activation, the specific contribution of ERK1 and ERK2 in BRAFV600E-driven responses in vivo has never been explored. Here we describe the first murine model suitable for genetically dissecting the ERK1/ERK2 impact in multiple phenotypes induced by ubiquitous BRAFV600E-expression. We unveil that ERK1 is dispensable for BRAFV600E-dependent lifespan shortening and for BRAFV600E-driven tumor growth. We show that BRAFV600E-expression provokes an ERK1-independent lymphocyte depletion which does not rely on p21CIP1-induced cell cycle arrest and is unresponsive to ERK-chemical inhibition. Moreover, we also reveal that ERK1 is dispensable for BRAFV600E-triggered cytotoxicity in lungs and that ERK-chemical inhibition abrogates some of these detrimental effects, such as DNA damage, in Club cells but not in pulmonary lymphocytes. Our data suggest that ERK1/ERK2 contribution to BRAFV600E-driven phenotypes is dynamic and varies dependently on cell type, the biological function, and the level of ERK-pathway activation. Our findings also provide useful insights into the comprehension of BRAFV600E-driven malignancies pathophysiology as well as the consequences in vivo of novel ERK pathway-targeted anti-cancer therapies.
Active electronic skin: an interface towards ambient haptic feedback on physical surfaces
Authors: Guo Yuan , Wang Yun , Tong Qianqian , Shan Boxue , He Liwen , Zhang Yuru , Wang Dangxiao
Published: May 2024

In the era of ubiquitous computing with flourished visual displays in our surroundings, the application of haptic feedback technology still remains in its infancy. Bridging the gap between haptic technology and the real world to enable ambient haptic feedback on various physical surfaces is a grand challenge in the field of human-computer interaction. This paper presents the concept of an active electronic skin, characterized by three features: richness (multi-modal haptic stimuli), interactivity (bi-directional sensing and actuation capabilities), and invisibility (transparent, ultra-thin, flexible, and stretchable). By deploying this skin on physical surfaces, dynamic and versatile multi-modal haptic display, as well as tactile sensing, can be achieved. The potential applications of this skin include two categories: skin for the physical world (such as intelligent home, intelligent car, and intelligent museum), and skin for the digital world (such as haptic screen, wearable device, and bare-hand device). Furthermore, existing skin-based haptic display technologies including texture, thermal, and vibrotactile feedback are surveyed, as well as multidimensional tactile sensing techniques. By analyzing the gaps between current technologies and the goal of ambient haptics, future research topics are proposed, encompassing fundamental theoretical research on the physiological and psychological perception mechanisms of human skin, spatial-temporal registration among multimodal haptic stimuli, integration between sensing and actuation, and spatial-temporal registration between visual and haptic display. This concept of active electronic skin is promising for advancing the field of ambient haptics, enabling seamless integration of touch into our digital and physical surroundings.
An innovative molecular approach towards the cost-effective entomological authentication of honey
Authors: Zhang Guozhi , Zhang Yanzheng , Yuan Bin , Tiang En Ruth , Li Shanshan , Zheng Huoqing , Hu Fuliang
Published: May 2024

Honey authentication and traceability are crucial not only for economic purposes but also for ensuring safety. However, the widespread adoption of cutting-edge technologies in practical applications has been hampered by complex, time-consuming sample pre-treatment processes, the need for skilled personnel, and substantial associated expenses. This study aimed to develop a simple and cost-effective molecular technique to verify the entomological source of honey. By utilizing newly designed primers, we successfully amplified the mitochondrial 16S ribosomal RNA gene of honey bees from honey, confirming the high quality of the extracted DNA. Employing RFLP analysis with AseI endonuclease, species-specific restriction patterns were generated for honey derived from six closely related honey bees of the Apis genus. Remarkably, this method was proven equally effective in identifying heat-treated and aged honey by presenting the same RFLP profiles as raw honey. As far as we know, this is the initial research of the simultaneous differentiation of honey from closely related honey bee species using the restriction endonuclease AseI and mitochondrial 16S rRNA gene fragments. As a result, it holds tremendous potential as a standardized guideline for regulatory agencies to ascertain the insect origins of honey and achieve comprehensive traceability.
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18
Authors: Wolfson David W. , Kim Nam Kyun , Lee Ki Hong , Beyersdorf Jared P. , Langberg Jonathan J. , Fernandez Natasha , Choi Dahim , Zureick Nadine , Kim Tae Yun , Bae Seongho , Gu Jin-Mo , Kirschman Jonathan L. , Fan Jinqi , Sheng Christina Y. , Gottlieb Sen Danielle , Mettler Bret , Sung Jung Hoon , Yoon Young-sup , Park Sung-Jin , Santangelo Philip J. , Cho Hee Cheol
Published: May 2024

The adenovirus-mediated somatic transfer of the embryonic T-box transcription factor 18 (TBX18) gene can convert chamber cardiomyocytes into induced pacemaker cells. However, the translation of therapeutic TBX18-induced cardiac pacing faces safety challenges. Here we show that the myocardial expression of synthetic TBX18 mRNA in animals generates de novo pacing and limits innate and inflammatory immune responses. In rats, intramyocardially injected mRNA remained localized, whereas direct myocardial injection of an adenovirus carrying a reporter gene resulted in diffuse expression and in substantial spillover to the liver, spleen and lungs. Transient expression of TBX18 mRNA in rats led to de novo automaticity and pacemaker properties and, compared with the injection of adenovirus, to substantial reductions in the expression of inflammatory genes and in activated macrophage populations. In rodent and clinically relevant porcine models of complete heart block, intramyocardially injected TBX18 mRNA provided rate-adaptive cardiac pacing for one month that strongly correlated with the animal’s sinus rhythm and physical activity. TBX18 mRNA may aid the development of biological pacemakers.
Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation
Authors: Cakmak Yusuf O. , Khwaounjoo Prashanna , Pangilinan Joseph , Wise Innes K. , Burrows Chris , Kolakshyapati Pranish , Williams Zoe , Bannon Paul
Published: May 2024

Non-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine. The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs’ blood flow. Porcine animal model (n = 8) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80 Hz, 10 Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal-only or Abdominal and hind limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10 Hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p = 0.0233) and renal arteries (p = 0.0493). Arterial pressures (p = 0.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.
Investigation of high-dose radiotherapy's effect on brain structure aggravated cognitive impairment and deteriorated patient psychological status in brain tumor treatment
Authors: Ma Jianpeng , Cao Hetao , Hou Dongmei , Wang Weiqi , Liu Tingting
Published: May 2024

This study aims to investigate the potential impact of high-dose radiotherapy (RT) on brain structure, cognitive impairment, and the psychological status of patients undergoing brain tumor treatment. We recruited and grouped 144 RT-treated patients with brain tumors into the Low dose group (N = 72) and the High dose group (N = 72) according to the RT dose applied. Patient data were collected by using the HADS and QLQ-BN20 system for subsequent analysis and comparison. Our analysis showed no significant correlation between the RT doses and the clinicopathological characteristics. We found that a high dose of RT could aggravate cognitive impairment and deteriorate patient role functioning, indicated by a higher MMSE and worsened role functioning in the High dose group. However, the depression status, social functioning, and global health status were comparable between the High dose group and the Low dose group at Month 0 and Month 1, while being worsened in the High dose group at Month 3, indicating the potential long-term deterioration of depression status in brain tumor patients induced by high-dose RT. By comparing patient data at Month 0, Month 1, Month 3, Month 6, and Month 9 after RT, we found that during RT treatment, RT at a high dose could aggravate cognitive impairment in the short term and lead to worsened patient role functioning, and even deteriorate the overall psychological health status of patients in the long term.