bluuebunny/crossref_metadata_2025 huggingface dataset:
Food allergies, intestinal microbiota and probiotics
Authors: Kornienko E. A.
Published: March 2022

There are many studies devoted to the study of the intestinal microbiota. They prove the leading role of microorganisms in the formation of the immune response of the host. Intestinal microbiota contributes to the switch of preferential differentiation of Th-lymphocytes from Th2-type, typical for newborns, to the formation of Tr-cells (regulatory) with a corresponding increase in the formation of TGF-β and IL-10. Consequently, immunological tolerance is formed under the influence of the intestinal microbiota. This process occurs in the first months of life and has a long-term effect, setting the features of the body’s immune response to external infectious and food antigens, which determines the predisposition to the development of food allergies later in life. This article describes the factors that influence the colonization of the baby’s gut. Maternal gut microbiota, maternal health, mode of delivery (natural childbirth or cesarean section), type of feeding (breastfeeding or formula feeding) - all these factors affect the colonization of the gut and the formation of an immune response. In addition, lactobacilli and bifidobacteria play a critical role in the formation of immunological tolerance. Probiotics can modulate the immune response similar to the intestinal microbiota. Lactobacillus and bifidobacterium infant strains are optimal. Clinical studies have proven the effectiveness of perinatal and early administration of probiotics for the prevention of food allergies. A balanced combination of Lactobacillus rhamnosus and Bifidobacterium longum is a symbiosis of bacteria that enhances the effectiveness of each other, which promotes the optimal establishment of the intestinal microbiocenosis from birth and is the prevention of both infectious diseases and food allergies. A combination probiotic containing both Lactobacillus rhamnosus and Bifidobacterium longum seems to be the optimal choice.
Breastfeeding challenges in infants with nasal breathing difficulties: alternative supplemental feeding methods
Authors: Zhdanova S. I. , Kostycheva A. A. , Levadnaya A. V. , Gutorova T. V. , Alekseenko G. A. , Sivokhina A. A.
Published: March 2022

This review article highlights the features of breastfeeding in case of obstructed nasal breathing in infants, special attention is paid to non-sucking or alternative methods of bottle feeding with expressed breast milk for the period when breastfeeding is not possible or formula supplementation is necessary as an addition to breastfeeding.Breathing through the mouth is considered a pathological adaptation due to difficulty in nasal breathing and is associated with the development of many pathological conditions. There is an evidence base that prolonged breastfeeding is associated with nasal breathing at an older age, as well as the correct formation of the bite. The anatomical and physiological features of the structure of the upper respiratory tract in infants predispose to a more frequent occurrence of difficult nasal breathing compared to adults, which causes difficulties in breastfeeding, up to the refusal of the child’s breast. Therefore, knowledge of modern methods of supplementary feeding with expressed breast milk for this period, as well as ways to effectively and safely deal with nasal congestion in infants, will help doctors and parents to overcome the difficult period of the disease, accompanied by nasal congestion without loss and maintain breastfeeding for as long as possible, in the light of modern data on influence of breast milk on the subsequent life of mother and child.The main method of treatment for nasal congestion of various etiologies is irrigation-elimination therapy. According to the literature, good tolerability and no side effects were found when using a nasal aspirator used in conjunction with isotonic saline.
Experience with the use of the drug cycloferon in the treatment of rotaviral infection in children
Authors: Borisova O. V. , Bochkareva N. M. , Polezhaeva N. S. , Zhilyakovа T. A. , Tsareva N. G. , Berdnikova E. V.
Published: March 2022

Introduction. Rotavirus infection is the leading cause of acute gastroenteritis in young children. Due to the lack of etiotropic treatment of viral gastroenteritis, the interest of scientists and practitioners in the use of antiviral drugs is increasing. Studies of domestic authors have proven that the low molecular weight interferon inductor – meglumine acridonacetate has antiviral, immunoregulatory and anti-inflammatory activity.Aim. Evaluation of the efficacy and safety of the antiviral drug meglumine acridonacenate in the treatment of acute gastroenteritis of rotavirus etiology in children aged 4–7 years in a hospital setting.Materials and methods. A prospective analysis of cases of treatment with meglumine acridonacetate for moderately severe rotavirus gastroenteritis in preschool children (n = 29, group I) was carried out. The comparison group consisted of patients receiving standard therapy (n = 31, group II). The presence of rotavirus infection was confirmed by the detection of the pathogen antigen in the feces. Meglumine acridonacetate was prescribed according to the scheme, parenterally, every other day.Results and discussion. The effectiveness of therapy with an antiviral drug on the 3rd day of treatment of moderately severe rotavirus gastroenteritis was 79.3% (p < 0.05). The elimination of the main clinical symptoms of the disease was noted on days 2–3: a decrease in the symptoms of intoxication, fever, a significant decrease in the duration of vomiting and diarrhea (p < 0.05), a reduction in the pathogen elimination period by 2.67 days (p < 0.01), meglumine acridonacetate was well tolerated, no side effects of the drug were detected.Conclusions. Meglumine acridonacetate can be recommended for the complex treatment of moderate rotavirus infection from the first days of the disease.
Immunoprobiotic in pediatrics: from concept to practice
Authors: Panova L. D. , Khismatullina Z. R. , Davletbayeva G. A. , Panova A. N. , Bulatova S. T.
Published: March 2022

Introduction. The role of disturbance of the intestinal microbiota in the development of diseases of infectious genesis and the possibility of using probiotics as an immunomodulatory agent are confirmed by the evidence base of numerous studies.Purpose. To study the results of using a multi-strain immunoprobiotic from the first days of acute respiratory infection as an emergency prevention, for the purpose of reducing the duration and severity of the disease.Materials and methods.Children from 2 to 10 years old took part in the clinical observation: the main group (45 children) received a multi-strain immunoprobiotic in accordance with the instructions for use for 1 week, starting from the 1–2 day of acute respiratory infection and the comparison group (37 children) who did not receive an immunoprobiotic.Results and discussion. As a result of the study, the effectiveness and safety of the use of an immuno-probiotic in children of preschool and primary school age, when prescribed from the first days of acute respiratory infection, and its positive effect on the course of the disease were shown. The duration of the disease in patients receiving the immunoprobiotic was statistically significantly less, and the severity of the disease was milder than in the comparison group. The incidence of repeated respiratory infections during one month after discontinuation in the main observation group was 3.1 times lower than in the comparison group. At the end of the experiment, statistically significantly higher levels of leukocytes, eosinophils, monocytes and the absolute number of lymphocytes were revealed in the comparison group that did not receive the immunoprobiotic.Conclusions. The obtained results allowed to substantiate the use of a multi-strain immuno-probiotic as a non-specific immunomodulatory agent for emergency prevention when prescribed from the first days of a respiratory infection for the purpose to reduce the duration and severity of the disease.
Lysosomal acid lipase deficiency – an underestimated cause of hypercholesterolemia in children
Authors: Pshenichnikova I. I. , Zakharova I. N. , Skorobogatova E. V. , Bocharova T. I. , Koba Yu. V.
Published: March 2022

Lysosomal acid lipase deficiency (LAL-D) is a rare, progressive, autosomal recessive disease, which develops due to impaired degradation and subsequent intra-lysosomal accumulation of triglycerides and cholesterol esters causing dyslipidemia. The clinical manifestations of the disease presumably depend on the residual activity of the enzyme, lysosomal acid lipase. A profound deficiency of the enzyme known as Wolman’s disease has an onset in the first 6 months of life. The disease reveals itself by dyspeptic disorders in the form of vomiting and diarrhea, lack of weight gain, hepatosplenomegaly, and adrenal calcification. If the Wolman’s disease is not treated, children die within the first 6 months as a result of exhaustion caused by malabsorption syndrome combined with progressive deterioration of liver and adrenal glands. Partial deficiency of lysosomal acid lipase manifests itself at a later age and is called cholesterol ester storage disease. Its clinical presentations include hepatosplenomegaly, elevated transaminases, hypercholesterolemia, and, in some cases, hypertriglyceridemia. Liver failure is the main cause of death in the natural course of cholesterol ester storage disease. Delayed diagnosis of the disease leads to its progression causing irreversible liver damage. The implementation of mass screening programs with the determination of cholesterol levels in childhood is critical to identifying asymptomatic patients.The article presents a clinical case of a patient aged 3 years. The molecular genetic testing showed a mutation in exon 8 of the LIPA gene: NM_000235.3:c.894G>A synonymous variant in the homozygous state. It was also found that both parents of the girl had this type of mutation in the heterozygous state. The patient was prescribed sebelipase alfa in a dose of 1 mg/kg once every 14 days. The treatment was well tolerated. Due to the early verification of the diagnosis and timely pathogenetic therapy, the prognosis of the course of LAL-D, the duration and quality of life of the child were considered to be favourable.Raising the awareness of doctors along with the introduction of effective screening programs for the timely detection of dyslipidemia in children contributes to timely diagnosis and early initiation of pathogenetic therapy, which can increase the life expectancy of patients with lysosomal acid lipase deficiency and improve their quality of life.
Surgical treatment of aneurysmal bones cysts
Authors: Ovechkina A. A. , Zherdev K. V. , Сhelpachenko O. B. , Semenova L. A. , Petelguzov A. A. , Timofeev I. V. , Yatsyk S. P.
Published: March 2022

Introduction. Bone cysts are one of the most common tumor-like bone diseases of childhood, most often occurring in the 1st and 2nd decade of life. According to the world medical literature, there is still no consensus on the best methods of treating bone cysts.Aim – to evaluate the effectiveness of surgical treatment of aneurysmal bone cysts (ABC) in children with the use of allografts of biological (animal and human) origin.Materials and methods. This study included 56 pediatric patients with ABC treated at The National Medical Research Center for Children’s Health, Russia, Moscow. 37 patients with aneurysmal bone cysts (29 active ABC, 8 inactive ABC) underwent surgical treatment. Our follow-up period ranged from 12 months to 80 months. In the postoperative period, the examination was carried out at a period of 3, 6, 12, 18, 24 months and then once a year, while assessing: the presence/absence of the recurrence (radiologically), the timing of functional recovery of the operated segment, the timing of X-ray reconstruction of the graft, the assessment of physical and emotional components of the patients’ quality of life were evaluated using the PedsQL questionnaire at admission and within 12 months from the date of surgery.Results and discussion. In 37 cases of surgical treatment of ABC with the use of allografts of biological origin, the recurrence presented in 7 patients (19%) – these patients, who had an active ABC, required repeated surgical interventions. The average time of complete bone repair in the lesion site ranged from 9 months to 22 months (14 months on average). Functional recovery of the operated segments was on average 10 months for the upper extremities and 12 months for the lower extremities.Conclusion. The use of allografts of biological origin is effective in the case of inactive aneurysmal bone cysts. In case of active ABC the effectiveness of bone grafting with allografts of biological origin is reduced.
Inflammatory diseases of the pharynx in children
Authors: Drozdova M. V. , Preobrazhenskaya Yu. S. , Ryazantsev S. V. , Pavlova S. S.
Published: March 2022

Introduction. Inflammatory diseases of the lymphoid ring of the pharynx in children are widespread and account for more than 30% in the structure of ENT pathology. Lymphoid tissue, especially the palatine tonsils, largely determines the formation of local and general protective reactions of the child’s body.The aim of this work is to assess the efficacy and safety of using topical bacterial lysate in chronic tonsillitis of streptococcal and herpes viral etiology in frequently ill children.Materials and methods. The study was conducted on a sample of 31 children aged 7–17 who were treated in the pediatric department of the Saint Petersburg Research Institute of Ear, Throat, Nose and Speech inpatiently or outpatiently, which were divided into 2 groups. Group 1 consisted of 15 children with decompensated chronic tonsillitis of streptococcal etiology, who were prescribed tonsillectomy according to indications. Group 2 consisted of 16 children with chronic compensated tonsillitis, who, after an acute respiratory infection, showed signs of acute pharyngitis in the form of pain and discomfort in the throat, perspiration, low-grade body temperature. In both groups children were prescribed to take topical baclerial lysates.Results. A subjective pain relief of sore throat in patients (groups 1 and 2) was observed from day 2–3 of administration of the topical bacterial lysate. The clinical therapeutic effect resulted in decreased intensity of inflammation of the posterior pharyngeal wall, reduction in size and tenderness of regional lymph nodes from day 4–5 of administration of the drug. The clinical recovery from acute pharyngitis in children of both groups was observed in 98% of cases at visit 3.Conclusion. The persistence of pathogenic viruses and bacteria contributes to the development of secondary immunodeficiency states and participates in the formation of a kind of “vicious circle” In these causes prescription of topical baclerial lysates may be an effective conservation therapy as well as antibiotics and antiviral drugs. The drug showed its efficacy in the treatment of acute and chronic diseases of the pharynx in children of both viral and bacterial etiology.
Proposal to reduce potable water consumption in a metallurgical industry in the metropolitan region of Curitiba city – case study
Authors: Gil Wellington T. , Valle Pablo D. , Deschamps Fernando
Published: March 2022

This research is based on the need to reduce the consumption of potable water due to the current water scenario allied to the company's socio-environmental situation. The metallurgical industry is the third industrial group with the highest consumption of potable water in the world. This study can be used in other metallurgical industry segments besides residences, public and private works. Currently, the water usage scenario of Curitiba and the metropolitan region is classified as ‘quantitative critical’, which can cause companies to accelerate the process of water collection through alternative sources. Through surveying potential sources for water collection, three sources of capture and one point for press water were classified. For validation of these potentials, chemical-physical tests were performed on the water samples. Subsequently, reservoir sizing calculations were performed based on the ABNT NBR 15527 standard. Thus, the first idea of reducing potable water consumption was up to 84%, even in the month with the lowest volume of rain.
Heterogeneous degradation of amoxicillin in the presence of synthesized alginate-Fe beads catalyst by the electro-Fenton process using a graphite cathode recovered from used batteries
Authors: Kadji Hakima , Yahiaoui Idris , Akkouche Fadila , Boudrahem Farouk , Ramdani Sonia , Saidane Anissa , Manseri Amar , Amrane Abdeltif , Aissani-Benissad Farida
Published: March 2022

Iron alginate beads (Fe-Alg) were prepared, characterized and implemented for the degradation of amoxicillin (AMX) by the heterogeneous electro-Fenton process using a graphite cathode recovered from used batteries. Scanning electron microscopy (SEM) showed that (Fe-Alg) beads have a spherical shape and the results of energy dispersive spectrometric (EDS) revealed the presence of iron in (Fe-Alg). Optimization of the operating parameters showed that a complete degradation of AMX was achieved within 90 min of heterogeneous electro-Fenton treatment by operating under these conditions: initial AMX concentration: 0.0136 mM, I = 600 mA, [Na2SO4] = 50 mM, pH = 3, T = 25 °C, ω = 360 rpm. The corresponding chemical oxygen demand (COD) abatement was 50%. Increasing the contact time increased the COD abatement to 85.71%, after 150 min of heterogeneous electro-Fenton treatment. The results of the kinetic study by using nonlinear methods demonstrated that the reaction of AMX degradation obeyed to a pseudo-second-order kinetic. Iron content of 4.63% w/w was determined by the acid digestion method. After 5 cycles of use, the Alg-Fe catalyst depletion was only 8%. Biodegradability was remarkably improved after electro-Fenton pretreatment, since it increased from 0.07 initially to 0.36. The heterogeneous electro-Fenton process had efficiently eliminated AMX and it increased the biodegradability of the treated solution.
Natural Medicines as Gastro-protective Therapy in the Treatment of
Peptic Ulcer: A Multifaceted Approach
Authors: Singh Pranjal Kumar , Easwari Trichy Siva
Published: March 2022

Gastrointestinal (GI) disorders are the ailments of the digestive tract that affect its
function, including digestion, absorption, and excretion. The dysfunction of the gastrointestinal
tract may occur due to infections by bacteria, parasites, and viruses. Peptic ulcer disease is a gastrointestinal
tract disorder of the stomach and duodenum associated with infection of Helicobacter
pylori. Helicobacter pylori is regarded as the worldwide causative agent responsible for the
etiology of peptic ulcer and gastric carcinoma. The existing drug therapies are good healers in
this situation, but due to resistance problems and side effects of drugs, researchers have been
working to find out some safe alternatives. Interestingly, the medicinal herbs have been used for
treating several disorders, including peptic ulcers, and are considered an effective and safer alternative
to existing drugs. They are also considered eco-friendly, easily available, safe, and less
toxic than traditional treatment therapy. Combining herbal medicines with natural products has
been shown effective in treating peptic ulcers. In this review, the medicinal plants used against
H. pylori infection have been discussed. The mechanisms of herbal drugs in healing peptic ulcers
involve inhibition of H+ K+ ATPase pump, reduction in gastric acid secretion, and protection of
gastric mucosa that have also been elaborated in this review. The phytochemicals responsible for
biological activity have been summarized in the present article. The combination of herbs and
natural products in the form of the polyherbal formulation may also be helpful as an effective
therapy for treating peptic ulcers. Medicinal plants may offer the researchers new chemical molecules
to explore as future drugs or as biochemical agents to unravel the etiology of the disease.
Microwave 3D Imaging System Featuring the Phase Coherence Factor for
Improved Beamforming
Authors: Abdullah Mohd. Zaid , Rasappan Rasammal , Anwar Nik Syarim Nik , Zanoon Tareq Faisal , Sun Tiang Sew , Ain Mohd. Fadzil
Published: March 2022

Background:

This paper presents an improved radar-based imaging system for breast cancer
detection that features p-slot ultrawideband antennae in a 32-array set-up. The improved reconstruction
algorithm incorporates the phase coherence factor (PCF) into the conventional delay and sum
(DAS) beamforming algorithm, thus effectively suppressing noise arising from the side- and gratinglobe
interferences.

Methods:

The system is tested by using several breast models fabricated from chemical mixtures formulated
on the basis of realistic human tissues. Each model is placed in a hemispherical breast radome
that was fabricated from polylactide material and surrounded by 32 p-slot antennae mounted in four
concentric layers. These antennae are connected to an 8.5 GHz vector network analyser through two
16-channel multiplexers that automatically switch different combinations of transmitter and receiver
pairs in a sequential manner.

Results:

The system can accurately detect 5 mm tumours in a complex and homogeneously dense 3D
breast model with an average signal-to-clutter ratio and full-width half-maximum of 7.0 dB and 2.3
mm, respectively. These values are more competitive than the values of other beamforming algorithms,
even with contrasts as low as 1:2.

Conclusion:

The proposed PCF-weighted DAS is the best-performing algorithm amongst the tested
beamforming techniques. This research paves the way for a clinical trial involving human subjects.
Our laboratory is planning such a trial as part of future work.
Complications and Efficacy of Sinopharm Vaccine among Liver and Kidney
Transplantation
Authors: Khodashahi Rozita , Aliakbarian Mohsen , Sabbagh Mahin Ghorban , Rezayat Kambiz Akhavan , Khodashahi Mandana , Khaleghi Ebrahim , Moghaddam Maliheh Dadgar , Razmkhah Baran , Nazar Mahdi Nik , Sheikhi Nadia
Published: March 2022

Background:

There are various vaccines against the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). However, vaccination may lead to some complications.

Objective:

This study aimed to investigate the complications of transplant recipients who received
the Sinopharm COVID-19 vaccine.

Methods:

This was a retrospective cross-sectional study conducted among 667 transplant recipients
(211 liver transplant recipients and 456 kidney transplant recipients) who received the Sinopharm
COVID-19 vaccine from March to August 2021 and had medical records in Montaserieh Hospital,
affiliated to Mashhad University of Medical Sciences, Mashhad, Iran. The demographic and clinical
information, as well as patient's symptoms after each dose of the vaccine, were recorded.

Results:

Only 16.8% and 13.7% of the patients experienced some symptoms following the first and
second doses of the Sinopharm vaccine, respectively. No significant difference was observed between
patients younger than 50 years and those aged 50 years and over in terms of the complication
rate of the Sinopharm vaccine (P>0.005). Vaccine failure was reported in 10% of the cases;
however, the mortality rate due to infection with the Delta variant of COVID-19 in this population
was reported to be 0.7%.

Conclusion:

Based on the obtained results, adverse reactions of the Sinopharm COVID-19 vaccine
are generally mild, predictable, and non-life-threatening both in the first and second doses. Vaccine
failure was reported in 10% of the cases; however, mortality due to infection with the Delta variant
of COVID-19 was reported in less than 1% of the cases.
Modulation of Bleomycin-induced Oxidative Stress and Pulmonary Fibrosis
by Ginkgetin in Mice via AMPK
Authors: Wang Lei , Zhang Chaofeng , Ren Guoqing , Xu Gonghao , Li Renshi , Xie Haifeng , Cui Zhengguo
Published: March 2022

Background:

Ginkgetin, a flavonoid extracted from Ginkgo biloba, has been shown to exhibit broad anti-inflammatory, anticancer, and antioxidative bioactivity. Moreover, the extract of Ginkgo folium has been reported on attenuating bleomycin-induced pulmonary fibrosis, but the anti-fibrotic effects of ginkgetin are still unclear. This study was intended to investigate the pro-tective effects of ginkgetin against experimental pulmonary fibrosis and its underlying mechanism.

Methods:

In vivo, bleomycin (5 mg/kg) in 50 μL saline was administrated intratracheally in mice. One week after bleomycin administration, ginkgetin (25 or 50 mg/kg) or nintedanib (40 mg/kg) was administrated intragastrically daily for 14 consecutive days. In vitro, the AMPK-siRNA trans-fection in primary lung fibroblasts further verified the regulatory effect of ginkgetin on AMPK.

Results:

Administration of bleomycin caused characteristic histopathology structural changes with elevated lipid peroxidation, pulmonary fibrosis indexes, and inflammatory mediators. The bleo-mycin-induced alteration was normalized by ginkgetin intervention. Moreover, this protective ef-fect of ginkgetin (20 mg/kg) was equivalent to that of nintedanib (40 mg/kg). AMPK-siRNA trans-fection in primary lung fibroblasts markedly blocked TGF-1-induced myofibroblasts transdiffer-entiation and abolished oxidative stress.

Conclusions:

All these results suggested that ginkgetin exerted ameliorative effects on bleomycin-induced oxidative stress and lung fibrosis mainly through an AMPK-dependent manner.
Antifungal Activity of Plant Secondary Metabolites on Candida albicans: An Updated Review
Authors: Khan Andleeb , Moni Sivakumar Sivagurunathan , Ali M. , Mohan Syam , Jan Huma , Rasool Saiema , Kamal Mohammad A , Alshahrani Saeed , Halawi Maryam , Alhazmi Hassan A
Published: March 2022

Fungal infections have been increasing continuously worldwide, especially in immunocompromised individuals. Fungi, regarded as eukaryotic pathogens, have many similarities to the host cells, which inhibit anti-fungal drug development progress. Various fungal model systems have been studied, and it was concluded that Candida spp. is the most common disease-causing fungus. Candida species are well known to cause infections not only in our mouth, skin, and vagina, but they are also a frequent cause of life-threatening hospital bloodstream infections. The morphological and developmental pathways of Candida have been studied extensively, providing insight into the fungus development. Candida albicans is known to be the most pathogenic species responsible for a variety of infections in humans. Conventional anti-fungal drugs, mainly azoles drugs available in the market, have been used for years developing resistance in C. albicans. Hence, the production of new anti-fungal drugs, which require detailed molecular knowledge of fungal pathogenesis, needs to be encouraged. Therefore, this review targets the new approach of "Green Medicines" or the phytochemicals and their secondary metabolites as a source of novel anti-fungal agents to overcome the drug resistance of C. albicans, their mechanism of action, and their combined effects with the available anti-fungal drugs.
Study on Decoupling Control Strategy of Redundant Parallel Hybrid
Vibration Isolation Platform
Authors: Zhang Bing , Yan Liu , Qiu Longtao , Huang Hua , Cai Jiamin , Yang Xinlong , Tang Shaodong
Published: March 2022

Background:

The vibration isolation platform (VIP) can greatly reduce the risk of damage to
dynamic equipment caused by external vibration interference and provide the most stable and reliable
working environment for dynamic equipment.

Objective:

Aiming at the problems of small vibration isolation dimension, low bearing capacity, serious
motion coupling, and narrow vibration isolation bandwidth in the field of vibration isolation of dynamic
load equipment, a hydraulic redundant six degrees of freedom parallel vibration isolation platform
(PVIP) with active and passive composite vibration isolation support is proposed.

Methods:

The dynamic coupling model of active and passive hybrid vibration isolation (APHVI) of redundant
PVIP is established, and the matrix diagonal decoupling control strategy and fuzzy PI control
theory are combined. Analysis of passive vibration isolation performance and APHVI performance of
VIP is done.

Results:

The simulation results show that the effect of APHVI based on fuzzy PI decoupling control is
better than that of passive vibration isolation and matrix diagonal decoupling control.

Conclusion:

Fuzzy PI control can effectively attenuate more than 98 % of the disturbance, significantly
improve the vibration isolation performance and decoupling effect of the platform, and expand the effective
vibration isolation bandwidth.
Basic materials of literature genre text in Sasak language
Authors: Paridi Khairul , Sudika I Nyoman , Syahbuddin Syahbuddin , Murahim Murahim , Ashriany Ratna Yulida
Published: March 2022

Teaching materials about literature in the 2013 Curriculum should be text-based, but after careful discussion of the material in the curriculum and Sasak language textbooks in primary and secondary education, the emphasis is more on the value of beauty and character of story characters. In addition, teaching materials about the text of the Sasak literary genre are presented in Indonesian, not in Sasak; the amount of literature both in the form of fiction and poetry and others is still very limited. The limited material about literary genre texts has the consequence that learning about literary texts does not receive adequate attention. Based on these problems, this paper aims to discuss the text of the genre of folk literature in the Sasak language in terms of text structure, linguistic tools, and community values contained in it. Learning based on literary genre texts will support language skills and can help children understand the value and beauty of Sasak literature. The results of the study of literary genre texts are expected to help teachers prepare teaching materials for local content in the Sasak language.
Impact of Decrease in Cultural Tourism Visits on Gross Regional Domestic Product of Blitar Regency During The Covid-19 Pandemic
Authors: Arifah Siti , Auwalin Ilmiawan , Qodrunnada Alissa , Vauzi Rezhi
Published: March 2022

The COVID-19 virus has become a global pandemic and has spread to various countries, including Indonesia. The pandemic causes turmoil in the health sector and the economy. The impacts of the pandemic are not only at the national level but also the provincial and district level. The district of Blitar is no exception. Blitar is a district in East Java Province with a diverse cultural heritage. Cultural tourism directly contributes to the regional revenue, which can help the recovery of the local economy. This study examines the impact of the COVID-19 pandemic on the number of cultural tourism visits and its implications on the Gross Regional Domestic Product (GRDP) of Blitar. The results show that while the tourist visits contribute to the GRDP of Blitar, the contribution has been negatively impacted by the pandemic.
The Impact Of Digital Technology In The Entrepreneur Transition During The Covid-19 Pandemic
Authors: Tasmilah Tasmilah , Pramono Devanto , Syafitri WIldan
Published: March 2022

The Covid-19 pandemic has decreased the number of entrepreneurs assisted by permanent workers in Indonesia. Using SAKERNAS Data of August 2019 and 2020, this study uses multinomial logistic regression to estimate the impact of digital technology in the entrepreneurial transition during the Covid-19 pandemic. The results show that digital technology and the internet have a negative and significant effect on the transition of formal entrepreneurship in Indonesia. The use of digital technology and the internet will prevent formal entrepreneurs from transitioning into informal entrepreneurs or leaving entrepreneurship. Increasing digital technology usage and the internet for promotional and sales purposes will enable entrepreneurs to survive amid a pandemic. In addition, building information technology infrastructure such as Base Transceiver Station (BTS), especially in rural areas, is necessary to increase internet coverage and encourage business scale-up in rural areas.
Sanctuary Politics and the Borders of the Demos: A Comparison of Human and Nonhuman Animal Sanctuaries
Authors: Meijer Eva
Published: March 2022

Sanctuary traditionally meant something different for humans and nonhuman animals, but this is changing. Animals are increasingly seen as subjects, and, similar to human sanctuaries, animal sanctuaries are increasingly understood as political spaces. In this article I compare human and nonhuman sanctuaries in order to bring into focus under- lying patterns of political inclusion and exclusion. By investigating parallels and differ- ences I also aim to shed light on the role of sanctuaries in thinking about and working towards new forms of community and democratic interaction, focusing specifically on the role of political agency and voice.
I begin by briefly discussing the political turn in animal philosophy, in which nonhuman animals are conceptualized as political actors. I then discuss ‘Zatopia’, a thought experiment that shows that viewing sanctuaries as separate from larger political structures runs the risk of repeating violence, and I investigate parallels with certain practices and policies in farmed animal sanctuaries. In order to overcome the obstacles thus identified, I turn to the concept ‘expanded sanctuary’, which explicitly focuses on connections between sanctuary and larger political structures. I discuss two examples of expanded sanctuary in which the agency and voices of those seeking or taking sanctuary are foregrounded: VINE Sanctuary, and the Dutch migrant collective WE ARE HERE. In the final section I briefly touch upon the consequences of these con- siderations for our understanding of sanctuary in relation to political membership and reforming communities.
Laypeople’s Online Health Information Search Strategies and Use for Health-Related Problems: Cross-sectional Survey
Authors: Chiu Yen-Lin , Tsai Chin-Chung , Liang Jyh-Chong
Published: March 2022

Background

With the increase in the use of the internet to search for health information about health-related problems, there is a need for health care professionals to better understand how their patients search for and use the online health information that may influence their medical decision making.

Objective

The aims of this study are to explore laypeople’s online health information search strategies and examine the relationships between their search strategies and utilization behavior of online health information.

Methods

Two scales, namely match and elaboration, were used to measure patients’ basic search strategies (ie, simple approach) and advanced search strategies (ie, integrative approach), respectively. In addition, the consultation scale was used to evaluate the participants’ use of online health information to consult doctors and others. A total of 253 outpatients without university education were purposely selected and surveyed. The participants were outpatients at a university-affiliated teaching hospital. Partial least squares-structural equation modeling (PLS-SEM) was performed to analyze the measurement model to specify the measurement validation. In addition, the structure model of PLS-SEM was evaluated to examine the path correlations between variables and to execute interaction effect and curvilinear relationship analyses.

Results

The results of the path correlation analysis by PLS-SEM showed that both elaboration strategy (path coefficient=0.55, P<.001) and match strategy (path coefficient=0.36, P<.001) were positively correlated with consultation on online health information with doctors and others. In addition, interaction effect and curvilinear relationship analyses indicated that there was a significant interaction effect between elaboration and match on consultation (path coefficient=–0.34, P<.001) and a significant curvilinear relationship between match and consultation (path coefficient=–0.09, P=.046).

Conclusions

Increasing patients’ exposure to online health information through both a simple search approach (ie, match strategy) and a complex search approach (ie, elaboration strategy) may lead them to appropriately use the information to consult doctors and others. However, the results of interaction effect and curvilinear relationship analyses highlighted the essential role of the elaboration strategy to properly locate, evaluate, and apply online health information. The findings of this study may help health care professionals better understand how to communicate with their patients through the health information on the internet.
Therapeutic effect of Corbrin (Bailing) capsule on patients with renal insufficiency: a meta-analysis (Preprint)
Authors: Zhou Xiaoling , Ye Jianhua , Guo Xiaoyan , Chen Menghua
Published: March 2022

BACKGROUND

Background: Renal insufficiency (RI) is a common kidney disease in the elderly people.

OBJECTIVE

Objectives: Corbrin capsule is an over-the-counter (OTC) drug, improving the renal function of RI patients. This meta-analysis is aimed to assess the clinical efficacy of Corbrin capsule on the treatment of RI.

METHODS

Methods: A meta-analysis was conducted using databases containing PubMed, Cochrane Library, CNKI, Wanfang and Weipu Database until August 2020. Randomized controlled trial of Corbrin capsule in the treatment of RI was included. Blood urea nitrogen (BUN), serum creatinine (Scr), 24 h urine protein quantification (24 h UPQ) and endogenous creatinine clearance (ECC) were pooled by standardized mean difference (SMD) and 95% confidence interval (CI), whereas the therapeutic efficiency (TE) outcome was pooled by odd ratio (OR) and 95% CI. Heterogeneity was assessed by Q test and I2 statistics using a random-effect model.

RESULTS

Results: Eleven eligible articles involving 1,100 patients (594 in the Corbrin capsule group and 516 in the control group) were chosen. Compared with control subjects, the SMD of was -1.3302 for BUN (95% CI: -2.2428– -0.4176), -1.3532 for Ser (95% CI: -2.0617– -0.6448), -1.7868 for UPQ (95% CI: -2.8901– -0.6836), and 1.7842 for ECC (95% CI: 0.6774–2.8910). The OR of TE was 1.9786 (95% CI: 0.7153–5.4734). No statistical evidence of publication bias was found among studies (t = 0.5627, P = 0.6737).

CONCLUSIONS

Conclusion: The therapeutic effect of Corbrin capsule on RI patients is relatively good.
Web-based system to capture consistent and complete real-world data of physical therapy interventions following total knee replacement
Methods to define and test structured data to accelerate comparative effectiveness research (Preprint)
Authors: Franklin Patricia , Oatis Carol A , Zheng Hua , Westby Marie D , Peter Wilfred , Laraque-Two Elk Jeremie , Rizk Joseph , Benbow Ellen , Li Wenjun
Published: March 2022

UNSTRUCTURED

Introduction:
The electronic health record (EHR) has the potential to facilitate consistent clinical data capture to support excellence in patient care, quality improvement, and knowledge generation. Despite widespread EHR use, the vision to transform the healthcare system, and its data, to a “learning healthcare system” generating knowledge from real-world data is limited by the lack of consistent, structured clinical data. The purpose of this paper is to demonstrate the design of a web-based structured clinical intervention data capture system and its evaluation in practice. The use case is ambulatory physical therapy (PT) treatment after total knee replacement (TKR), one of the most common and costly procedures today.

Methods:
To identify the PT intervention type and intensity (dose) used to treat knee arthritis patients following TKR, an iterative user-centered design process refined an initial list of PT interventions generated during preliminary chart reviews. Input from practicing PTs and national and international experts refined and categorized the interventions. Next, a web-based, hierarchical, structured system for intervention and intensity documentation was designed and deployed.
Results:
The PT documentation system was implemented by 114 PTs agreeing to record all interventions at patient visits. Data for 161 patients with 2615 PT visits were entered by 83 PTs. No technical problems with data entry were reported, and data entry required less than two minutes per visit. Two percent of interventions could not be categorized and were recorded using free text.
Discussion:
The use of user-centered design principles provides a roadmap for developing clinically feasible data capture systems that employ structured collection of uniform data for use by multiple practitioners across institutions to complement and augment existing EHRs. Secondarily, these data can be analyzed to define best practices and to disseminate knowledge to practice.
Physical activity and physical exercise mHealth interventions. A systematic review (Preprint)
Authors: Caparrós Toni , Fernandez-Chimeno Mireya , Moize Violeta , Sanchez-Fuentes Jose Antonio , Aurín Eva , Carrión Carme
Published: March 2022

UNSTRUCTURED

The inclusion of physical activity and physical exercise prescription in the field of mHealth, offers a new field of research in an increasingly digitized society. In this context, it is necessary to assess the applicability, reliability and adequacy of the control variables and assessment of the volume and intensity of physical exercise, taking into account the criteria of individualization and specificity of the pathology. This systematic review was to study the adherence and effectiveness of physical activity or physical exercise mHealth programs depending on its variables, communication channels and technological resources. A literature research was carried out using the Pubmed, Science Direct, Scopus and Google Scholar platforms. Of 809 initial results, 13 clinical studies were included in the analysis, related to cardiac (4), oncological (3), pulmonary (1), Parkinson's (1) diseases, as well as the promotion of FA in sedentary people (2), general population (1) and pregnant women (1). En relación a la efectividad de la intervención en términos relativos a PA, 9 de los resultados finales (70%) se observaron diferencias estadísticamente significativas de mejorar en el grupo experimental. The most used variables are the daily steps and the minutes of physical activity or exercise per day. The most used technological resources are specific applications and wristband FitBit®. Main communication channels are SMS and the social network Facebook. mHealth interventions had a greater effectiveness of and adherence to experimental PA or PE prescription programs using digital devices than in those prescribed in person or without technological support. Workload was evaluated using variables of a quantitative and non-specific nature, and and there are no interventions specifically designed to meet the needs or technological capabilities of their target population
Кадрове забезпечення стоматологічної допомоги в окремих регіонах України
Authors: Krut A.G.
Published: March 2022

Актуальність. Наявність і кваліфікаційний рівень кадрових ресурсів відіграє ключову роль у покращанні здоров'я населення, зокрема, порожнини рота, більшості хвороб якої можна запобігти. Упродовж 1993-2013 років чисельність лікарів-стоматологів в Україні зростала щороку на 1,3%, а у 2014-2018 роках – зменшувалася на 2,9%. Має місце зростання чисельності лікарів-стоматологів у приватному секторі, трудова міграція в інші країни, значна регіональна варіабельність забезпеченості населення, що обумовлює актуальність проблеми. Мета: провести аналіз кадрового забезпечення стоматологічної допомоги (на прикладі Житомирської, Харківської та Чернігівської областей); визначити напрями розвитку кадрових ресурсів стоматологічного профілю. Матеріали та методи. Медико-статистичний аналіз даних Центру медичної статистики МОЗ України, Державної служби статистики України та обласних стоматологічних поліклінік досліджуваних регіонів за 2010-2019 роки (усього 18 од.). Методи: логіко-структурного та порівняльного аналізу, узагальнення, графічний, описового моделювання. Результати. У досліджуваних областях при від’ємній динаміці кадрового забезпечення, працював потужний корпус лікарів стоматологічних спеціальностей високого кваліфікаційного рівня. Коефіцієнт сумісництва у 2010-2019 роках (у Житомирській області 0,99 – 0,88, Чернігівській –1,03 – 0,95, Харківській – 0,84 – 0,87, Україні – 0,89 – 0,87) вказав на надлишок фізичних осіб лікарів щодо штатних посад. У той же час кадровий потенціал використовувався не на повну потужність, що доведено постійно низьким рівнем здоров’я порожнини рота населення та звернень за профілактичною стоматологічною допомогою. Причиною проблем з надання профілактичних заходів, зокрема, є ліквідація в ході реформування галузі закладів стоматологічного профілю на первинному рівні, низька забезпеченість лікарями загальної практики – сімейної медицини, прогалини у підготовці зубних гігієністів. Висновки. Першочергові заходи з розвитку кадрових ресурсів стоматологічного профілю полягають у дослідженні потреб населення у стоматологічній допомозі, приведення у відповідність їм спеціалістів стоматологічного профілю та державного замовлення на їх підготовку закладами вищої освіти. Забезпечення профілактичної стоматологічної допомоги можливо за умов підготовки достатньої кількості лікарів первинної медичної допомоги, зубних гігієністів і включення останніх у команди спеціалістів і фахівців первинної ланки.
Consideraciones para una historia de la traducción poética en México (1950-1970): métodos y cartografías
Authors: Ruiz Rodilla Álvaro
Published: March 2022

Los estudios de historia de la traducción son un campo en auge. Centrado en la traducción de poesía en publicaciones periódicas culturales de 1950 a 1970, este artículo muestra algunas orientaciones metodológicas para su desarrollo en México. Si los esfuerzos de construcción de índices y bases de datos se reafirman como un pilar de confianza fundamental, también se explora una opción complementaria: las posibilidades de la visualización cartográfica. Así, se discute la viabilidad de adaptar al contexto de la investigación mexicana la metodología histórica de Anthony Pym y su interés preeminente por los traductores de carne y hueso. Esto implica el hallazgo de ciertos puntos de encuentro entre sus propuestas y algunos referentes imprescindibles de la geografía literaria como marco metodológico.
A Study of Covid-19 Pandemic Towards the Changing Scenario of School Education and Its Effects on Children
Authors: Yadav Anuradha , Singh Rajeev
Published: March 2022

Abstract: The outbreak of Covid-19 epidemic has affected our education system. The educational institutes were closed due to the this epidemic around the world, due to which the education and the learning process of children was badly affected. During the pandemic, due to the sudden closure of schools, the traditional classroom based Indian schooling system has now shifted to an unplanned online based education system for which we were not prepared well neither mentally nor technically. The access to digital devices is not very common in India especially in those areas which are backward in network and other cyber facilities. A group of guardians, one of the main constraints is the ability and affordability of the device and the internet. Due to this pandemic the child labours are increasing and the mental health of the children is also affected adversely. Keywords: Covid pandemic, online education