bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ROLE OF OPERATING SYSTEM UPGRADE IN OPTIMIZING THE OPERATION OF THE RAILWAY STATION
Authors: O. A. Hodoskina  , Y. V. Matyushkova
Published: May 2019

Purpose. This article aimed at increasing the efficiency of the Gomel station by introducing an automated system for the commercial inspection of trains and cars (ASCI TC), as well as, developing the options for optimizing the operation of a railway station as a whole. Methodology. In the course of the study, the methods of scientific search, statistical analysis, synthesis, and elements of the theory of system modelling were used to study the hierarchical structures that arise in determining causal relationships in identifying adverse factors of the station. Findings. The key role of the marshalling yards in operational work is explained by the fact that they perform the main work in composition and breaking-up of trains, on which the required fleet of cars for performing a given volume of traffic, the speed of delivery of cargo shipments largely depends. Therefore, the work of the marshalling yards has a significant impact on the expenditures of railways, the quality of transport services, on meeting the demand for transportation and industry revenues. Consequently, increasing the efficiency of the marshalling plants contributes to the achievement of optimal operational and economic indicators for the industry as a whole. In the course of the study, authors considered the ways to optimize the station's work, determined the innovative ways to improve the technological process of the sorting station as a whole, identified the practical significance of updating the existing operating system for the station, its feasibility and efficiency, and calculated the logistical effect of the ASCI TC implementation through a detailed study of its operation, identifying its advantages and disadvantages. Originality. Based on the study of methodical sources and scientific developments in the field of technological features and improvement of the work of freight stations, the main directions for optimizing the operation of the Gomel marshalling yard are identified at the methodological level, which are the most promising measures. The reasons affecting the idle time of cars at the marshalling yard were identified and structured, as well as appropriate organizational measures were formed to reduce downtime. Practical value. Conducted analytical research and proposed solutions of identified problems will improve the technology and increase the quality of commercial inspection, create safe working conditions and improve the occupational safety of train pickers, and will also contribute to increasing the efficiency of the railway station under inspection, both technologically and economically.
Perfil de pacientes acometidos por lesões orais infecciosas em um centro de referência do Nordeste Brasileiro
Authors: Cerqueira Joana Dourado Martins , Ramos Tarsila de Carvalho Freitas , Souza Rafael Cabral de Albuquerque , Almeida Lorena Araujo , Cunha Gabriel Levi da Silva , Batista Laise Rocha
Published: May 2019

INTRODUÇÃO: A cavidade oral constitui-se em uma importante porta de entrada para agentes infecciosos de inúmeras doenças com manifestações orais de doenças sistêmicas. OBJETIVO: Realizar um estudo clínico e epidemiológico dos pacientes portadores de doenças infecciosas, cujas lesões foram biopsiadas no ambulatório do Centro de Referência de Lesões Bucais. MATERIAIS E MÉTODOS: Foi realizado um estudo retrospectivo de corte seccional onde se verificou todos os prontuários dos pacientes com diagnóstico de doença infecciosa entre os anos de 1998 e 2015, comprovados através do exame clínico e/ ou histopatológico em um Centro de Referência de Lesões Bucais. RESULTADOS: Foram selecionados 384 prontuários baseados nos critérios de inclusão da amostra desta pesquisa. As infecções fúngicas foram as mais prevalentes com 299 casos (78%), sendo que 241(82%) pacientes eram do sexo feminino, com idade a partir de 40 anos, n=237 (87%). Houve uma associação estatisticamente significante para todos os grupos de lesões com a variável idade (p<0,05). CONCLUSÃO: A lesão mais prevalente nesta pesquisa foi a Estomatite protética, uma variante clínica da Candidíase eritematosa e os resultados apontaram o uso de prótese como o principal fator de risco para o desenvolvimento desta infecção em cavidade oral.
EFEITO LOCAL DO USO DO SCHINUS TEREBINHTHIFOLIUS E ASSOCIAÇÕES (SANATIVO®) NO PÓS-OPERATÓRIO DE EXODONTIAS DE MOLARES INFERIORES
Authors: Fonsêca Azoubel Maria Cecília , Rios Ribeiro Neiana Carolina
Published: May 2019

Objectives: evaluate the clinical topical effect of the Sanativo® in the alveolus of mandibular molars during the post-operatory period. Methods: Sixty volunteers were randomly divided into test group (Sanativo®), PCA (Malvatricin®), PCB (Clorexidina) e Control (Solução fisiológica). The patients were instructed to realize mouthwashes three times a day during 07 days. The parameters were considered: size of wound and visual inflammatory aspect in three experimental times (immediately after the surgical procedure, 48 hours and 07 day after the intervention. Tukey analysis with significance level of 5% was performed, beyond the visual descriptive analyses. Results: The results did not point increasing effect by the use of Sanativo® over the evaluated parameters, not proving, therefore, additional benefit in the use of the referred medicine. Conclusions: The use of Sanativo ® showed no additional benefit in reducing the size of the wound, was not therefore comparable to chlorhexidine, which confirmed its superior efficacy.
INFLUÊNCIA DO CONDICIONAMENTO ÁCIDO NO REPARO DE CERÂMICAS ODONTOLÓGICAS UTILIZANDO RESINA COMPOSTA
Authors: Souza Francisca Carvalho , Santos Lorena Rodrigues , Freitas Anderson Pinheiro De , Silveira Silvio Alberto Almeida , Lisboa Marcio Vieira , Lisboa José Augusto Ataíde
Published: May 2019

The use of ceramic restorations is constantly indicated and used in dental clinics because of their structural and aesthetic qualities, however despite being a material with excellent mechanical properties it may present fractures. The complete replacement of a prosthetic restoration has an elevated cost and needs a longer clinical time. So the repair of ceramics using composite resin has been a good alternative in cases of fracture. The objective of this study is to evaluate through a literature review the influence of acid etching in the repair of ceramic with composite resin. The data collection was performed through the selection of articles published in the databases SciELO, LILACS and Bireme using the following descriptors: surface treatment, composite resin and dental ceramics. According to the findings gathered, the repair of fractured ceramic surface can be performed intra-orally through the mechanical and chemical treatment of the fractured surface. For acid sensitive ceramics it is reported in literature the effectiveness of hydrofluoric acid treatment in promoting superficial alterations, however, the longevity of such adhesion between ceramic and composite resin after etching is still questionable.
FRATURA DE CÔNDILO MANDIBULAR: TRATAMENTO CIRÚRGICO OU CONSERVADOR?
Authors: Oriá Alana Behrens , Prates Soares Zerbinati Lívia , Arcadinos Leite Eugenio
Published: May 2019

The type and severity of trauma injury; and the etiology of facial fractures is different according to the population studied. With the more stringent traffic laws, there was a reduction of facial fractures caused by automobiles accidents, but it still appears as the main cause and the prevalence of male and facial fractures. These fractures of the mandible condyle correspond 25-35% of mandible fractures diagnosed through radiographs projection Towne, panoramic and computed tomography. The same feature as the main etiological factors trauma by direct assault, car accidents, bicycle fall, fall from height and injury by firearms. Diagnosis of condylar fractures in pediatric patients should be very strict by the difficulty of obtaining information about the history of trauma, especially due to age of the patients affected. The etiology of condylar fractures in pediatric patients varies according to the stage of the child’s life (the 0-6 year of life and from the 6th year of life). The treatment of these fractures, especially in pediatric, when mishandled can cause permanent deformity. The treatment can be surgical or conservative, and should be made after the analysis of the age and gender of the patient, etiology and clinical conditions of fracture, time from the trauma, and dental occlusion. In pediatric patients, in most cases, the of first choice treatment is the conservative approach, because the ability of bone growth and bone remodeling that occurs.
MANUTENÇÃO DE VIA AÉREA SUPERIOR APÓS REDUÇÃO FECHADA DE FRATURA NASAL: RELATO DE CASO
Authors: Dantas Renata Moura Xavier , De Paula Daniel Miranda , Malaquias Pietry Dy Tarso Inã Alves , Macedo Thiago Felippe Oliveira de , Carneiro Júnior Bráulio
Published: May 2019

Objective: To present a case of closed reduction of nasal fracture with modification of the technique of anterior nasal packing and subsequent maintenance of the upper airway in the immediate postoperative. Case Description: patient´s sporting accident victim (capoeira) with a history of trauma in the middle third of the face and epistaxis at the time of trauma. On physical examination, facial edema was observed in the nasal region, bilateral periorbital ecchymosis and edema, subconjunctival hemorrhage in the right eye, lateral-deviation of the nasal dorsum to the left side, and crackling nasal obstruction, especially in the right nostril, and other bony contours of face preserved. The imaging exams evidence suggestive signs of fracture of nasal bone. The reduction of the fracture took place in closed form under local anesthesia. After the reduction, we opted for the use of an intra-nasal probe Nelaton, aiming maintaining upper airway, followed by anterior nasal packing with vaseline gauze. The patient was followed up for one month, and six months post op. Conclusion : the reduction of fractures of the nasal bones with airway maintenance, closed form under local anesthesia is a technique that can be performed with good safety margin, giving the patient greater comfort in the postoperative period.
ABRASIVOS: UMA ANÁLISE DE DENTIFRÍCIOS COMERCIALIZADOS EM SALVADOR
Authors: Santos Lydia De Brito , Rios Ana Carla Ferreira , Oliveira Viviane Maia Barreto , Lopes Sônia Cristina Freitas Lemos , Dantas Taiana Silva
Published: May 2019

Most toothpastes sold in Brazil contains abrasive composition with the function of preventing the formation of spots or pigmented film and burnish the tooth surface, however, the indiscriminate use of abrasives has generated discussion regarding the effects of this component. Objective: To evaluate dentifrices sold in the city of Salvador as to its commercial presentation, regarding the inormation contained in the packages related to abrasives, in order to verify if guidelines are offered to the public to assist them in choosing those products and to the professionals when it comes to the guiding elements of the prescription. Methodology: We have analyzed 45 packages of toothpaste, randomly purchased from supermarkets in Salvador, for two years. We have observed the following: component that guides the classification of toothpaste, type and concentration of abrasive and instructions with respect to the degree of abrasiveness. Results: All trademarks contained abrasive analyzed singly or in combination; eight types of abrasives have been found: Calcium Carbonate (27%), Silica (26%), Sodium Bicarbonate, Silicon Dioxide, Titanium Dioxide, trisodium phosphate, aluminum oxide and sodium silicate. Manufacturers have associated to the dentifrices naturals extracts with the purpose to prevent the dental color change without tooth and gengival aggression caused by abrasives associations. Conclusion: Lack of guidance on packaging about the level of abrasiveness of toothpaste that can guide patients and professionals to its rational use.
AUTOTRANSPLANTE DENTÁRIO: UMA OPÇÃO REABILITADORA E VIÁVEL AO SUS
Authors: Rebouças Deyvid Silva , Cerqueira Lucas Souza , Andrade Eduardo Lima , Santos Heloisa Lais , Zerbinati Livia Prates Soares , Assis Adriano Freitas
Published: May 2019

The rehabilitation of teeth that have been lost by caries or fractures in young individuals, which still has growth potential, proves to be a challenge, especially for economically disadvantaged individuals, as conventional forms of rehabilitation such as fixed or removable dentures and prostheses implant at · Revista Bahiana de Odontologia. 2015 Abr;6(1):47-51 · 48 high cost. An alternative treatment for the replacement of compromised teeth is dental transplantation. The tooth transplantation is demonstrated as a viable option, mainly because it is a relatively simple, inexpensive and can be performed by the dentist in centers specialized in dentistry. Objective: The Objective of this paper is to review the literature about the transplant tooth and discuss the feasibility of using this technique as an alternative therapy for rehabilitation of children and adolescents assisted by public health services. Materials and methods: A search was conducted in the databases Pubmed, Bireme, Lilacs and Scielo, with issues related to oral rehabilitation in young people. Conclusion: The dental transplantation, it is shown as an effective technically and economically feasible to SUS.
ESTUDO DA PREVALÊNCIA DE LESÕES EM MUCOSA ORAL DE PACIENTES PORTADORES DE NECESSIDADES ESPECIAIS
Authors: Medrado Alena Peixoto , Chaoui Silva Daniela A. R. , C. Wanderley Flávia Godinho
Published: May 2019

AIM: The aim of this study was to evaluate qualiquantitative the most frequent oral lesions in special patients using two health centers. METHODS: Over a year, the records of 60 patients were assessed and data on age, gender, main complain, presence or absence of oral abnormalities, recorded were analyzed. Then an oral exam was performed to check possible pathologies in the oral mucosa of this population. RESULTS: The sample consisted of a greater number of males (53.3%) and those who declared themselves as black (35%). The most common lesion was inflammatory fibrous hyperplasia (40%), followed by gingival hyperplasia (26.6%) and candidiasis (11.6%). 18.3% of subjects reported perception of xerostomia. Many of these patients and or caregivers complained of difficulty in accessing dental care. CONCLUSION: Therefore, it is necessary a greater attention devoted to this population for dental care becomes more humanized.
O USO DE MEMBRANAS BIOLÓGICAS PARA REGENERAÇÃO ÓSSEA GUIADA EM IMPLANTODONTIA: UMA REVISÃO DE LITERATURA
Authors: Boaventura Zumaêta Costa José , Da Silva Fabrício , De Almeida Dultra Christiano , Farias Souza Laís , Nascimento Elyotte dos Santos Maria Clara
Published: May 2019

The significant development of biomaterials for use in clinical dentistry in the last decade has represented a powerful therapeutic tool in surgical activities, especially in the correction of bone defects. The guided tissue regeneration is a surgical practice in which it uses an artificial barrier called a biological membrane that serves as a barrier to epithelial migration to the success of new bone formation in areas of bone defects. Such membranes can be absorbable or not absorbable. This article discusses the use of the technique of guided bone regeneration techniques and the placement, composition, properties, advantages and disadvantages of the materials to be used.
ADMINISTRAÇÃO PROFILÁTICA DE AMOXICILINA EM CIRURGIAS DE TERCEIROS MOLARES RETIDOS EM PACIENTES SAUDÁVEIS: REVISÃO DE LITERATURA
Authors: Pedrosa Marlus Da Silva , Dourado Ferro Flávia Ennes , Férrer Pompeu José Guilherme , Da Costa Borba Márcia Socorro
Published: May 2019

Background: Impacted third molar surgeries are common procedures in clinical practice of dentists and are associated with several trans and postoperative complications. As a result, antibiotic prophylaxis is quite common. Aim: To investigate the scientific evidences regarding the prophylactic prescription of amoxicillin in third molar surgeries in healthy patients. Methods: It was carried out a literature review in the electronic databases SciELO, PubMed, LILACS, and Oviatt Library from December of 2015 to January of 2016, using as descriptors: amoxicillin, antibiotic prophylaxis, dental surgery, and third molar. Results and Discussion: Prophylactic administration of amoxicillin for third molar extraction is controversial in terms of its effectiveness in preventing post-surgical complications given that the scientific evidences about its advantages and disadvantages are still limited. Conclusion: In third molar extraction of healthy patients, amoxicillin given prophylactically should be carefully prescribed.
MANEJO DE PACIENTES COM HALITOSE ATENDIDOS NO SERVIÇO PÚBLICO DE SAÚDE
Authors: Araujo Luciana Mara Peixôto , Santana Ariane De Oliveira , Moura Iasmin De Sousa , De-Matos Jefferson David Melo , Dutra Marignês Theotonio dos Santos , Santos Carolina Carvalho de Oliveira , Fonseca-Silva Thiago
Published: May 2019

Halitosis is characterized by a foul odor emanating from the oral cavity. This condition is considered an embarrassing symptom with a significant social impact for the individual. The aim of this study was to evaluate the knowledge of professionals working on public health service about halitosis and to examine the criteria for referrals of suspected cases. This study had the participation of 37 health professionals including medical doctors and dentists. All participants answered a questionnaire about the etiology, management and treatment of halitosis. Among all the professionals analyzed 92% (n = 34) reported receiving patients complaining of halitosis. 88% (n = 22) of dentists and 50% (n = 06) of medical doctors believe that the main cause of halitosis has an oral origin. 89.1% (n = 33) of samples reported performing the treatment of halitosis. In addition, the complementary exam most requested for the diagnosis of halitosis was the radiograph of the face. The results suggest that there is a mistake in the management of patients with halitosis attended in the public health service. This study brings to light the need to educate and train medical doctors and dentists about the etiological factors, forms of diagnosis and treatment of halitosis.
UTILIZAÇÃO DO SISTEMA PIEZOELÉTRICO EM CIRURGIAS BUCAIS: INDICAÇÕES, VANTAGENS E DESVANTAGENS
Authors: De Carvalho Marcos Antônio Lima , Marques Gabriel , Trento Guilherme Dos Santos , Padovan Luis Eduardo Marques , Klüppel Leandro Eduardo
Published: May 2019

Ostectomy is a surgical maneuver that can affect tissue repair, increasing the overall morbidity of the procedure. The type of equipment or surgical armamentarium can directly influence bone repair. The aim of this study was to perform a literature review concerning the use of piezoelectric technology in oral and maxillofacial surgical procedures evaluating its indications, advantages and disadvantages. For the preparation of this critical review of the literature, a search of scientific articles was carried out in PUBMED until the year 2012. According to the inclusion and exclusion criteria porposed by the authors, a total of 28 articles were found compatible to the objective of the study. As a conclusion, it can be stated that the piezoeletric system has been shown to be a very promising surgical technique indicated to oral surgeries, and providing accurate, clean, and minimally traumatic osteotomies for the soft tissues. However, there is na accentuated wear of the ultrasonic tips increasing the costs of the system and the time spent in the procedures.
APLICAÇÃO DE ELEMENTOS FINITOS NA ODONTOLOGIA: UMA REVISÃO DE LITERATURA
Authors: Couto Brito João Victor , Garcia Dulcinéia Carlos , Crispim Silas da Silva , Melo de Matos Jefferson David , Gonçalves de Figueiredo Viviane Maria
Published: May 2019

Objetivo:objetiva-se com esta revisão de literatura esclarecer a aplicação da ferramenta de elementos finitos na Odontologia. Método:A revisão de literatura foi pautada em uma literatura específica e relevante, ou seja, artigos científicos, teses e livros sobre a temática abordada, utilizando as bases de dados das plataformas Pubmed.gov, Google.acadêmico, Scielo e outras bibliotecas virtuais. Considerações Finais: A Odontologia encontra no método dos elementos finitos uma forma de aprimorar a prática clínica, através de uma ferramenta computacional, para análises tensionais e estruturais nos materiais dentários e estruturas orofaciais.
Tratamento precoce da má oclusão de classe III – revisão de literatura
Authors: Ramadan Letícia Plícila Barbosa Magalhães , Santamaria Júnior Milton
Published: May 2019

A má oclusão Classe III de Angle é vista em ortodontia como de difícil resolução devido ao fator genético que a acompanha, sendo causada pela discrepância das bases ósseas maxilar e mandibular, o que leva a prejuízos estéticos e funcionais. Após a realização do tratamento precoce de acordo com a técnica e recursos escolhidos pelo profissional responsável, a afirmação do sucesso da terapêutica só pode, ainda, ser dada após o término do crescimento do paciente. O objetivo deste trabalho foi descrever de forma generalizada variedades de tratamento que podem ser executadas para amenizar o problema ainda na tenra idade, em dentição primária ou mista, além de apresentar aos profissionais que têm o primeiro contato com essa criança, a visão que devem ter a respeito da importância do tratamento precoce.
Análise quantitativa da motivação do paciente para cirurgia ortognática
Authors: Cardoso Lincoln Lara , Andrade Alex Alves da Costa , Gomes Bruno , Gasperini Giovanni , Toledo Italo , Sá Rodrigo Tavares de
Published: May 2019

INTRODUÇÃO: a cirurgia ortognática realizada para correção de deformidades dentárias e faciais, torna-se extremamente relevante, pois além da correção da oclusão, também beneficia a estética facial. A literatura sugere que os principais fatores que motivam o paciente a procurar tratamento, mais tarde, aceitam a cirurgia ortognática são claros e consistentes, e estes: melhora estética, melhora funcional do sistema estomatognático e autoestima. Portanto, a interpretação correta das expectativas do paciente é essencial para o estabelecimento de um plano de tratamento ideal para cada caso, de modo a não criar expectativas que não possam ser atendidas. Este estudo tem como objetivo apresentar o perfil e a motivação de pacientes que procuram tratamento ortodôntico-cirúrgico em clínica odontológica particular em Goiânia. MATERIAIS E MÉTODOS: A amostra constou de 188 prontuários que atenderam aos critérios de inclusão. A partir da amostra selecionada, foi realizada uma análise das seguintes variáveis: sexo, idade, queixa principal do tipo de deformidade apresentado e indicação de cirurgia. RESULTADOS: Os principais resultados mostraram que a maioria dos pacientes é do sexo feminino na proporção de 1,8: 1, com idade entre 21 e 30 anos, com queixas estéticas predominantes (43%), com perfil facial predominantemente da classe II (47,8%), mais comumente indicado cirurgia tipo bimaxilar (69,6)%. CONCLUSÃO: O desejo de melhora estética foi evidente em ambos os sexos. Entre as queixas funcionais, a dificuldade de mastigação foi observada com a primeira queixa principal.
CEMENTLESS TOTAL HIP ARTHROPLASTY: SHORT AND MID-TERM RESULTS
Authors: İPEK Deniz , PESİTLCİ Fatih İbrahim , ATEŞ Yalim , KOVALAK Emrah
Published: May 2019

Objective

The destruction of the joint cartilage either by age or

trauma can develop coxarthrosis limiting the motion of the patient, which is treated by the replacement of the whole joint with total hip arthroplasty. In this study,

we aimed to report our short and mid-term results and

discuss with the current literature on postoperative

results of cementless total hip arthroplasty (THA) in

patients with coxarthrosis.

Material and Method

One hundred thirty patients (86 female, 44 male) with

a mean age of 54.1±9.6 years who underwent total

hip arthroplasty with a cementless prosthesis included

in the study. The outcomes and complications of

the total hip arthroplasty were reviewed from patient’s

counseling charts, laboratory tests and radiographs.

retro

Results

There was a statistically significant difference between

pre (41.75±9.62) and postoperative (90.44±7.51)

mean modified Harris Hip Score measurements

(p
Atipik Femur Kırığı Olan Hastaların Karşı Femurda İnkomplet Kırık Varlığının Değerlendirilmesi
Authors: AKGÜN Ulaş , CANBEK Umut
Published: May 2019

Amaç:
Amacımız
komplet atipik femur kırığı nedeniyle cerrahi tedavi uygulanan hastaların karşı
femurlarını değerlendirerek inkomplet atipik femur kırığı varlığını araştırmak
ve inkomplet kırık saptanan hastalar ile inkomplet kırık gözlenmeyen hastaları
karşılaştırmaktır. 

Gereç
ve Yöntemler: Kliniğimizde Ocak 2012 ile Aralık 2018
tarihleri arasında atipik femur kırığı nedeniyle cerrahi tedavi uygulanan
hastalar retrospektif olarak incelendi ve 46 hastanın çalışmaya dahil edilme
kriterlerine uyduğu görüldü. Tüm hastaların yatışları sırasında karşı femurları
inkomplet atipik femur kırığı bakımından değerlendirilmişti. Hastalar karşı
femurda inkomplet atipik kırık varlığına göre iki gruba ayrıldı ve iki grubun
yaşları, cinsiyetleri, bifosfonat kullanım süreleri, vücut kitle indeks
değerleri, kalça ve lomber T skorları, serum parathormon, 25-OH Vitamin D ve
alkalen fosfataz düzeyleri karşılaştırıldı.

Bulgular:
Çalışmada
yer alan hastaların hepsi kadındı ve hastaların yaş ortalaması 72,9 ± 5,9 yıl
olarak bulundu. Hastaların ortalama bifosfonat kullanım süresi 7,9 ± 1,6 yıl
olduğu görüldü. 11 (%23,9) hastada karşı femurda inkomplet atipik kırık ile
karşılaşıldı. İki grubun yaşları, bifosfonat kullanım süreleri, vücut kitle
indeks değerleri, kalça ve lomber T skorları, serum parathormon, 25-OH Vitamin
D ve alkalen fosfataz değerleri arasında anlamlı fark saptanmadı.

Sonuç: Atipik femur kırığı olan tüm hastaların karşı
femurlarının inkomplet kırık varlığı açısından değerlendirilmesi gerektiği
kanaatindeyiz. İnkomplet atipik femur kırıklarının erken fark edilmesinin ve
komplet kırığa dönüşme riskinin değerlendirerek uygun tedavinin
gerçekleştirilmesinin hastalarda oluşabilecek ciddi morbiditeyi engelleyeceğini
düşünüyoruz.
UNC Chapel Hill Zebrafish Aquaculture Core (ZAC) Environmental Summary v2
Authors: Altemara Michelle
Published: May 2019

Zebrafish (Danio rerio) are a popular animal model used in a variety of research areas. As with all animal models, husbandry conditions, including environmental parameters, nutrition, and exposure to pathogens can affect research results. Additionly, zebrafish are tolerant of a wide range of environmental parameters, which has led to wide variation in husbandry practices across facilities around the world. The lack of standard conditions across zebrafish laboratories may play a role in irreproducible experiments. Therefore, a summary of these conditions for the year 2017 have been compiled for the Zebrafish Aquaculture Core (ZAC) facility at the University of North Carolina (UNC) Chapel Hill with the aim to have this data included in research articles published using our fish. As more institutions publish husbandry protocols, standard husbandry practices may emerge.
scNMT-seq v1
Authors: Clark Stephen
Published: May 2019

Here we describe the full wetlab protocol for scNMT-seq (single-cell nucleosome position, methylome and transcriptome sequencing), a plate-based single-cell multi-omic method. In scNMT-seq, a GpC methyltransferase is used to label non-nucleosome bound DNA thus encoding chromatin accessiblity information within the genomic DNA. Bisulfite conversion is then used to discriminate the two chromatin states which can be read from GpC dinucleotide positions. Endogenous DNA methylation is read from the CpG positions of the same molecules and gene expression data is obtained by capturing poly-A RNA on magnetic beads and pysically separating before the gDNA is bisulfite converted. This mRNA on beads is pocessed using Smart-seq2. The protocol is carried out in 96w plates and typically takes 3-4 days to complete.
Identiﬁcation of Linear Time-Varying Parameters of Nonstationary Systems
Authors: Le V. T. , Korotina M. M. , Bobtsov A. A. , Aranovskiy S. V. , Vo Q. D.
Published: May 2019

The paper considers the identification algorithm for unknown parameters of linear non-stationary control objects. It is assumed that only the object output variable and the control signal are measured (but not their derivatives or state variables) and unknown parameters are linear functions or their derivatives are piecewise constant signals. The derivatives of non-stationary parameters are supposed to be unknown constant numbers on some time interval. This assumption for unknown parameters is not mathematical abstraction because in most electromechanical systems parameters are changing during the operation. For example, the resistance of the rotor is linearly changing, because the resistance of the rotor depends on the temperature changes of the electric motor in operation mode. This paper proposes an iterative algorithm for parameterization of the linear non-stationary control object using stable LTI filters. The algorithm leads to a linear regression model, which includes time-varying and constant (at a certain time interval) unknown parameters. For this model, the dynamic regressor extension and mixing (DREM) procedure is applied. If the persistent excitation condition holds, then, in the case the derivative of each parameter is constant on the whole time interval, DREM provides the convergence of the estimates of configurable parameters to their true values. In the case of a finite time interval, the estimates convergence in a certain region. Unlike well-known gradient approaches, using the method of dynamic regressor extension and mixing allows to improve the convergence speed and accuracy of the estimates to their true values by increasing the coefficients of the algorithm. Additionally, the method of dynamic regressor extension and mixing ensures the monotony of the processes, and this can be useful for many technical problems.
Analyzing Robust Stability of an Interval Control System on the Basis of Vertex Polynomials
Authors: Gayvoronskiy S. A. , Ezangina T. A. , Khozhaev I. V. , Nesenchuk A. A.
Published: May 2019

In the paper, a characteristic polynomial of an interval control system, whose coefficients are unknown or may vary within certain ranges of values, is considered. Parametric variations cause migration of interval characteristic polynomial roots within their allocation areas, whose borders determine robust stability degree of the interval control system. To estimate a robust stability degree, a projection of a polytope of interval characteristic polynomial coefficients on a complex plane must be examined. However, in order to find a robust stability degree it is enough to examine some vertices of a coefficient polytope and not the whole polytope. To find these vertices, which fully determine a robust stability degree, it is proposed to use a basic phase equation of a root locus method. Considering the requirements to placing allocation areas of system poles an interval extension of expressions for angles included to the phase equation. The set of statements, allowing to find a sum of pole angles intervals in the case of degree of oscillating robust stability, were formulated and proved. From these statements, a set of double interval angular inequalities was derived. The inequalities determine ranges of angles of all root locus edge branches departure from every pole. Considered research resulted in a procedure of finding coordinates of verifying vertices of a coefficients polytope and vertex polynomials according to these vertices. Such polynomials were found for oscillating robust stability degree analysis of interval control systems of the second, the third and the forth order. Also, similar statements were derived for aperiodical robust stability degree analysis. Numerical examples of vertex analysis of oscillating and aperiodical robust stability degree were provided for interval control systems of the second, the third and the fourth order. Obtained results were proved by examining root allocation areas of interval characteristic polynomials examined in application examples of proposed methods.
Electroencephalogram in premature infants: from normal to pathological activity
Authors: Chegodaev D. A. , Pavlova N. V. , Lvova O. A. , Shalkevich L. V.
Published: May 2019

This study was aimed to assess electrophysiological brain activity in newborns of various gestational ages using electroencephalography (EEG). We summarized the data on the main EEG characteristics of premature infants and their dynamics and described the most common pathological EEG changes that can be identified at this age. We also discussed prognostic value of various neonatal EEG patterns (including their proportion and location), which allow verification of functional brain disorders at early stages.
Psychosomatic Associations Between Thinking Patterns and Parkinson's Disease from a Yoga Philosophy Perspective: A New Zealand Cross-Sectional Study
Authors: Maddela Sridhar , Buetow Stephen
Published: May 2019

When investigating the etiology of diseases, epidemiological observational studies traditionally deemphasize psychosomatic associations. Exploring cognitive behavior provides an insight into how psychosomatic associations affect disease. Yoga philosophy identifies the kleshas (mental afflictions) of ignorance, ego, desire, hatred, and fear of death with disease. This is because individuals' perceptions and beliefs generate and reflect streams of thought that may shape their behavior and manifest as, or predispose them to, particular disease(s). The present study takes a yogic philosophical perspective to help elucidate unexplored associations between thinking about different aspects of life and the severity of Parkinson's disease (PD). The study involved a cross-sectional sample survey. Parkinson's New Zealand selected a random sample of 990 of its members. A self-completed questionnaire was sent to them. It asked questions about how often, over the previous 4 weeks, they had thought about 18 aspects of life commonly associated with the kleshas. A completed questionnaire was returned by 319 people (32%). Respondents thought most about family (87%), health (64%), rest and sleep (57%), food (53%), and the future (52%). They reported thinking least about work (48%), sex (45%), death (42%), and being virtuous (39%). A weak, but hypothesized positive, association (r = 0.2, p < 0.000) was detected between PD severity and thinking about death. The study could not determine whether thinking about death was (1) a cause or consequence of PD severity, and (2) a premorbid behavior. However, the possibility that stress associated with thinking about death accelerates PD progression is consistent with yoga philosophy and with neurophysiological mechanisms associated with the psychosomatic connections. The findings are worthy of future testing. A retrospective cohort study and qualitative research could deepen understanding about the role of kleshas in PD.
Análisis cruzado de las evaluaciones profesor - alumno y el nivel de sinceridad: un enfoque estadístico.
Authors: Andrade-Garcia Billy , Toro-Sarmiento Stalin , Lora-Guzmán Harold
Published: May 2019

En este artículo, se aborda el tema de la evaluación del profesor Hetero. El objetivo es analizar si la relación entre el profesor Hetero y la evaluación es congruente con los valores y la sinceridad de los estudiantes. Esta investigación académica es descriptiva y se ha realizado a través de un enfoque cuantitativo. Se utilizan los siguientes instrumentos: Heteroevaluación, calificaciones de los alumnos, número de alumnos, número de fallos, tasa de fallos, período de tiempo y asignaturas, así como una prueba de valores. Se realizó un enfoque estadístico, que incluye pruebas de hipótesis, correlaciones, diferencias significativas y pruebas de dependencia. Algunos de los resultados muestran que las evaluaciones de los maestros a través de las evaluaciones hetero aumentan a medida que aumentan las calificaciones de los estudiantes. Además, hay evidencia estadística que explica cómo la cantidad de estudiantes que reproban un curso afecta negativamente la puntuación de evaluación del profesor. Los resultados de la prueba de estudio de valores indican que los estudiantes registran puntuaciones bajas de valor religioso y con un alto grado de valor económico. Esta evidencia puede ser perjudicial para el desarrollo de valores trascendentales como la sinceridad y la honestidad. Por lo tanto, la evaluación hetero podría distorsionarse debido a la fragilidad de la personalidad de los estudiantes.
Editorial Camino a la indexaciÃ³n
Authors: Ramirez Salinas Luis
Published: May 2019

La apariciÃ³n del cuarto nÃºmero de Ex Cathedra en negocios nos encuentra ante un nuevo desafÃ­o en el laborioso, a la vez venturoso, camino de ubicaciÃ³n y pertenencia a las Ã©lites de la producciÃ³n cientÃ­fica nacional, regional y mundial. Es el sendero de la indexaciÃ³n, que lo iniciÃ¡ramos allÃ¡, en el invierno del 2016. Un camino que â€“como ya lo manifestÃ¡ramos en su oportunidad, rememorando al poeta Antonio Machado- lo estamos haciendo al andar.
ArtÃ­culo DirecciÃ³n de Empresas Familiares: Propuesta aplicativa de gestiÃ³n basada en el Modelo de Davis y Tagiuri
Authors: AlcÃ¡ntara Mesias Enrique Erickson
Published: May 2019

El presente trabajo de investigaciÃ³n se constituyÃ³ a partir de diversas teorÃ­as e ideas fundamentadas de diversos expertos y autores relacionados con la gestiÃ³n de empresas familiares y la necesidad de complementar conceptos especÃ­ficos de administraciÃ³n basados en entender y explicar diversos modelos de direcciÃ³n de empresas familiares. Para estos efectos se utilizÃ³ el Modelo de Davis y Tagiuri (1982) como instrumento de orientaciÃ³n y continuidad en emprendimientos de familias empresarias, con la finalidad de centrar el concepto de empresa familiar en el contexto social peruano y, de esta manera, establecer la importancia de entender las relaciones, gestiÃ³n, propiedad y familia propuesto por el modelo en estudio. Finalmente, se presenta una propuesta inÃ©dita de gestiÃ³n de empresas familiares teniendo como base el Modelo de Davis y Tagiuri.
ArtÃ­culo Crisis polÃ­tica y comportamiento de los mercados de valores: aplicaciÃ³n al caso peruano
Authors: Rodriguez Abraham Antonio Rafael
Published: May 2019

El objetivo de la presente investigaciÃ³n ha sido determinar la existencia de una relaciÃ³n entre crisis polÃ­tica y comportamiento de los mercados de valores, especÃ­ficamente aplicado al caso peruano. La investigaciÃ³n ha tenido un enfoque mixto, de diseÃ±o no experimental y de corte longitudinal, de alcance descriptivo-correlacional, utilizÃ¡ndose la metodologÃ­a de estudio de eventos. En tanto que la variable â€œcrisis polÃ­ticaâ€ fue operacionalizada mediante la observaciÃ³n documental de 36 eventos polÃ­ticos ocurridos en el perÃ­odo diciembre 2017 â€“ marzo 2018, la variable â€œcomportamiento de los mercados de valoresâ€ lo fue a travÃ©s de la mediciÃ³n de la rentabilidad de la Bolsa de Valores de Lima (BVL), esto es, de la variaciÃ³n porcentual diaria del SP/BVL PerÃº General correspondiente a los 36 eventos polÃ­ticos. Los resultados han demostrado que no existe una relaciÃ³n estadÃ­sticamente significativa entre crisis polÃ­tica y rentabilidad de los mercados de valores. Esto sugiere que la crisis polÃ­tica ha sido incorporada por los inversionistas como parte de su riesgo polÃ­tico y los acontecimientos no representan mayor sorpresa. Finalmente, queda abierta la posibilidad de realizar nuevos estudios que permitan discernir la parte inesperada de la informaciÃ³n para medir su impacto en la rentabilidad de los mercados de valores.
Prescribing pattern of anticancer drugs in the medical oncology department of a tertiary care teaching hospital
Authors: Beedimani Ravindra S. , Zaman Sameer Uz , Potturi Sharat Chandra , M. Srinivas , Kumar K. Santosh
Published: May 2019

Background: To study drug utilization of anticancer drugs in the oncology inpatient department (IPD) of Kamineni Hospitals, L.B. Nagar, Hyderabad, India.Methods: One hundred prescription records were screened and analysed as per the study parameters from the oncology IPD of Kamineni Hospitals, Hyderabad. Commonly used anticancer drugs were recorded; furthermore, different types of carcinomas were noted.Results: Age group of patients was in between 04 and 80 years, 62 were females and 38 were male patients. The most common type of carcinoma was carcinoma of the breast (28%). Cisplatin was the most commonly used anticancer drug (29%). Adjuvant drugs were used in 98% of the patients.Conclusions: Incidence of cancer is more in females than males. Adjuvant and cytoprotective drugs used may have had a bearing on the relatively lower incidence of adverse effects.
Phenytoin induced toxic epidermal necrolysis: a case report
Authors: Barkakaty Sandipan , K. Girish
Published: May 2019

Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are severe idiosyncratic reactions characterized by fever and mucocutaneous lesions leading to necrosis and sloughing of the epidermis. The usage of anticonvulsants like carbamazepine, phenytoin, lamotrigine, phenobarbital are associated with high risk for occurrence of TEN. We present a case of toxic epidermal necrolysis in a 30 year old female probably induced by phenytoin. A 30 year old female was admitted to the emergency medicine department of KIMS hospital, Bengaluru. Lesions over the lips and oral cavity, multiple fluid filled blisters were present diffusely all over the body. Patient had a past history of oral cavity lesions with injection phenytoin. Patient is a known epileptic of over 12 years and was on treatment. Patient had a seizure attack 3 days back and visited nearby hospital and did not inform the doctor of her allergy to phenytoin. Patient was given inj phenytoin after which she developed oral lesions and also presented with fluid filled bullae all over the body. A diagnosis of toxic epidermal necrolysis was made based on clinical history and Scoreten score and was treated with betadine wash, fluconazole and antibiotics .The lesions improved significantly with the above management and patient recovered enough to be discharged from the hospital after 5 days. Severe and serious reactions such as toxic epidermal necrolysis can be caused by commonly used drugs like phenytoin.
Honey–old wine in new bottle: a surgically viable antibacterial and antiinflammatory fixator
Authors: Shivabasappa Shivakumar , Raghupathi Divakar Sullery , Uday Kumar Nallakukkala , Ravishankar Nagaraj , Kotekar Nalini
Published: May 2019

Background: Skin grafts are used to cover the healing wound, in which adherence of the graft to the wound bed is the important element. Honey has been shown to increase the adherence of skin grafts to wound beds and have antibacterial and anti-inflammatory effects and increase healing rate of wounds.Methods: In a single centre based prospective comparative study from November 2016 to April 2018, 60 patients (in 30 patients graft was fixed with sterilised honey, in 30 patients it was fixed with conventional methods like skin staples/sutures). All patients in two groups were evaluated for area of graft uptake, graft contracture, incidence of hematoma/seroma, mean hospital stay post surgery, post-operative pain, Infection rate and Cost effectiveness. Statistical analysis used are chi-square test, independent t test/ Mann-Whitney test, paired t test/ Wilcoxon test. P<0.05 is considered statistically significant.Results: Although graft uptake was same in both the groups, graft contracture, discharge from graft site and infection rate were less in the honey group. There was no seroma formation in the honey group. Honey significantly reduced postoperative pain (p<0.0001%) and is also cost-effective as the hospital stay was shorter in the honey group (p<0.0001%).Conclusions: Honey has strong adhesive properties, anti-inflammatory action and helps in minimization of scarring, and stimulation of angiogenesis as well as tissue granulation and epithelium growth. It also reduces surgical time for skin graft fixation. Sterilized honey has proven advantage as a skin graft fixator.
Clinical outcome in low socioeconomic patients with severe acute pancreatitis treated either with early nasogastric tube or total parenteral nutrition: a randomized controlled trial
Authors: Kumar Anil , Paswan Shiv S. , Kishor Shiv , Bhandari Vimal
Published: May 2019

Background: Early nasogastric feeding has shown beneficial effect in the low socioeconomic group of patient with severe acute pancreatitis (SAP). The current randomized controlled study was performed to assess the effect of early nasogastric feeding as compared to total parenteral nutrition (TPN).Methods: Fifty patients admitted with diagnosis of SAP were randomly allocated to receive nnteral feeding (EF) (at the rate of 25 ml/hour and was gradually increased up to 100 ml/hr) or TPN within 24 hours of hospital admission. The nutritional regimen was aimed to be iso-caloric between the two groups. Patient’s demographics, hospital stay, nutrition, total cost, complication, and mortality were observed for 1 month in follow up.Results: All fifty patients were completed the study. Patient demographics were similar in both groups. 38/50 belonged to low socioeconomic status in the study group (Twenty in EF and eighteen in TPN group). The complications were significantly lower in EF group (pancreatic infection (11 vs. 4, p=0.037), central venous catheter infection (EF=0 vs. TPN=8, p=0.002), multiorgan failure (EF=5, TPN=12, p=0.037). Early recovery in EF group was significant with the mean duration of hospital stay of 6.76 days as compared to 10.4 days in the TPN group. The mean expenditure in the EF group was 1268 as compared to 13688 Indian rupees in the TPN group.Conclusions: This study shows that early EF improves early recovery, lower complications and cost effective measure in SAP especially in low socioeconomic group of patients.
Analysis of risk factors for falls in geriatric patients: a single institutional experience
Authors: Amin Osama Shukir Muhammed , Amin Asso Faraidoon Ali , Karim Saad Kazim , Shwani Saad Suud , Thandoon Raed
Published: May 2019

Background: In elderly people, falls have been recognized as one of the major causes of disability and potentially preventable mortality. Authors analyzed the incidence of falls in elderly diabetic people who have been receiving insulin therapy versus those on oral hypoglycaemic agents (OHGAs).Methods: This observational study was conducted at the department of neurology of Shorsh military general teaching hospital and its outpatients’ department, Iraq, from April 1st to September 30st, 2016. A total of 100 diabetic patients older than 65 years of age, who had a history of one or more falls, were included in the study. The duration of diabetes, mode of its treatment, and its complications all were analyzed in addition to the risk factors for falls.Results: Females (n=57) outnumbered males (n=43) and the mean age of the patients was (71.2±3.6) years. Increasing patient’s age, long-standing diabetes, poor glycaemic control, insulin therapy, and polypharmacy (of 3 and more antidiabetic agents) were significantly and statistically encountered and associated parameters for the risk of falls. The presence of additional risk factors for falls (e.g., previous stroke, alcoholism, cardiac dysrhythmia, and osteoarthrosis) augmented this risk.Conclusions: Diabetes and its treatment render older people more liable for falls. The longer duration of the disease and the higher patients’ age (which were the commonest risks) are irreversible and non-correctable parameters for falls. Further analytic studies are required to unveil the role of each risk factor authors have detected.