bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-Emptively Managing Overtourism by Promoting Rural Tourism in Low-Density Areas: Lessons from Madeira
Authors: Majdak Piotr , de Almeida Antonio Manuel Martins
Published: January 2022

Overtourism refers not only to situations in which carrying capacity levels have been exceeded, but also to those in which tourists and residents share negative feelings of discomfort and other emotions, loss of quality of life and unpleasant experiences in their activities of daily life. The growing number of places struggling with the problem of overtourism suggests that brand new approaches are required to minimize the effects of excessive tourism. However, the impacts of overtourism are place-specific and a one-size-fits-all approach is inappropriate. Many destinations still have a considerable margin to manoeuvre but are nonetheless heading towards increasingly unsustainable levels of tourists per square kilometer. Such regions have time to take some pre-emptive measures based on principles of sustainable development using greener and energy-saving technologies. Over the past few decades, degrowth has arisen as an unorthodox approach based on principles of fairness and social and environmental justice. In certain areas, such as island economies, the economic dynamics remain largely dependent on the tourism sector, which forces the local actors to think and act differently. In this study, we analyze the strategies employed by Madeira to counter the negative effects of oversaturation in a pre-emptive way. The findings of this case study, based on the data at the county level, are enhanced by a panel data analysis of a number of relevant explanatory variables explaining the dispersion of tourists to the rural hinterland. The results suggest that the development of the rural hinterland has proven capable of exerting a progressively positive influence well beyond the borders of the rural hinterland by accommodating a growing share of the increasing numbers of tourists welcomed in the region in the 2002–2019 period, at the expense of the main capital city. This study confirms the importance and potential of the development of the rural hinterland to tackle overtourism in the main tourism areas. In terms of recommendations, it is suggested that local operators and policy-makers must develop efforts to research new ways to adopt energy-saving projects and develop tourisms products that incorporate eco-friendly behaviors.
Social Media in Sustainable Tourism Recovery
Authors: Hysa Beata , Zdonek Iwona , Karasek Aneta
Published: January 2022

In the light of the COVID-19 pandemic, it is crucial to manage tourist destinations to allow the recovery of tourism on the one hand and reduce its negative impact on the environment and the local community on the other. Information provided via social media (SM) by both residents and tourists can help restart tourism. This paper identifies ways of sharing travel experiences by tourists on social media. The research was conducted in Poland on a sample of 271 respondents from each generation using questionnaires. Results showed that the way tourists use SM during and after their trip differs by generation and gender what could be used in promoting responsible behaviour for sustainable tourism. Differences between generations can be observed in behaviours such as ongoing planning the trip, obtaining information about the place to stay, keeping a photo album for friends, and writing reviews. Moreover, more often than men, women use SM to obtain information about the place of stay and share their impressions of the trip by sending MMS or emails. Tracking tourists’ travel behaviour on social media will allow city managers to gather information and respond to their needs and expectations and ensure effective urban management and city promotion.
Effect of Regulation on the Increasing Price of Metals and Minerals to Meet the Challenges in Clean Energy Transitions: A Case Study of China
Authors: Xu Lin , Guo Zhenwei
Published: January 2022

Considering that the development of science and technology depends on metal support, the EU, USA, and China have issued a critical metal list on the development report. However, the scarce and important mineral deposits on a global scale will not be enough to meet the huge needs of economic development in the future. Many fields such as renewable energy, high-performance computing, and AI all require critical metals as essential supports. A proper price regulation of such important metals will contribute to the fair price power on the international market. In this paper, the pricing history and strategy of critical metal support are fully studied and discussed. Since China has become a major consumer country, China should gain fair price power in the market of important metals.
Innovating the Construction Life Cycle through BIM/GIS Integration: A Review
Authors: Celeste Giuseppe , Lazoi Mariangela , Mangia Mattia , Mangialardi Giovanna
Published: January 2022

The construction sector is in continuous evolution due to the digitalisation and integration into daily activities of the building information modelling approach and methods that impact on the overall life cycle. This study investigates the topic of BIM/GIS integration with the adoption of ontologies and metamodels, providing a critical analysis of the existing literature. Ontologies and metamodels share several similarities and could be combined for potential solutions to address BIM/GIS integration for complex tasks, such as asset management, where heterogeneous sources of data are involved. The research adopts a systematic literature review (SLR), providing a formal approach to retrieve scientific papers from dedicated online databases. The results found are then analysed, in order to describe the state of the art and suggest future research paths, which is useful for both researchers and practitioners. From the SLR, it emerged that several studies address ontologies as a promising way to overcome the semantic barriers of the BIM/GIS integration. On the other hand, metamodels (and MDE and MDA approaches, in general) are rarely found in relation to the integration topic. Moreover, the joint application of ontologies and metamodels for BIM/GIS applications is an unexplored field. The novelty of this work is the proposal of the joint application of ontologies and metamodels to perform BIM/GIS integration, for the development of software and systems for asset management.
Dense and Proximate Development—Daylight in the Downtown Area of a Compact City
Authors: Rynska Elzbieta , Yanchuk Maryia
Published: January 2022

Daylight is of utmost importance and should be the main source of light in most areas dedicated to working and living. When considering our contemporary way of living, it can be easily discerned that most of our life is spent indoors, yet in a typical architectonic design approach, daylight is too often hardly of consequence. Hence daylight becomes a critical factor. Designers comply with the legal requirements of the solar hours required for areas subjected to constant use. Simultaneously for electrical engineers’ daylight is only an additional source of light valued only where energy efficiency is concerned. The basic idea of this research is to, starting from the concept level, design the building’s volume in line with energy efficiency requirements and user expectations using daylight access strategy as the main parameter. This scope of research has been a subject of various scientific theses conducted within the last years at the Faculty of Architecture Warsaw University of Technology. This paper is dedicated to the latest and most developed outcomes. The presented solution is an architectonic point of view dedicated to the use of the daylight factor in office areas located in a dense city district that may support efficient energy requirements, including the requirements of the electric lighting system. Illumination values were set according to the BREEAM daylight and PN-EN 17037 Daylight of Buildings standard. The presented strategy is unconventional for Poland, but has the potential to be included in practice and should be developed further, together with electrical engineers, as a part of energy-saving solutions. Possibly, it should be followed simultaneously with the development of the compact cities ideas. It is hoped that it might be a starting point for discussion, and for a more detailed interdisciplinary research in the future.
Contamination Assessment and Source Apportionment of Metals and Metalloids Pollution in Agricultural Soil: A Comparison of the APCA-MLR and APCA-GWR Models
Authors: Ren Zhouqiao , Christakos George , Lou Zhaohan , Xu Haitao , Lv Xiaonan , Fei Xufeng
Published: January 2022

Metals and metalloids accumulate in soil, which not only leads to soil degradation and crop yield reduction but also poses hazards to human health. Commonly, source apportionment methods generate an overall relationship between sources and elements and, thus, lack the ability to capture important geographical variations of pollution sources. The present work uses a dataset collected by intensive sampling (1848 topsoil samples containing the metals Cd, Hg, Cr, Pb, and a metalloid of As) in the Shanghai study area and proposes a synthetic approach to source apportionment in the condition of spatial heterogeneity (non-stationarity) through the integration of absolute principal component scores with geographically weighted regression (APCA-GWR). The results showed that three main sources were detected by the APCA, i.e., natural sources, such as alluvial soil materials; agricultural activities, especially the overuse of phosphate fertilizer; and atmospheric deposition pollution from industry coal combustion and transportation activities. APCA-GWR provided more accurate and site-specific pollution source information than the mainstream APCA-MLR, which was verified by higher R2, lower AIC values, and non-spatial autocorrelation of residuals. According to APCA-GWR, natural sources were responsible for As and Cr accumulation in the northern mainland and Pb accumulation in the southern and northern mainland. Atmospheric deposition was the main source of Hg in the entire study area and Pb in the eastern mainland and Chongming Island. Agricultural activities, especially the overuse of phosphate fertilizer, were the main source of Cd across the study area and of As and Cr in the southern regions of the mainland and the middle of Chongming Island. In summary, this study highlights the use of a synthetic APCA-GWR model to efficiently handle source apportionment issues with spatial heterogeneity, which can provide more accurate and specific pollution source information and better references for pollution prevention and human health protection.
Logistics and Agri-Food: Digitization to Increase Competitive Advantage and Sustainability. Literature Review and the Case of Italy
Authors: Remondino Marco , Zanin Alessandro
Published: January 2022

This paper examines the current challenges faced by logistics with a focus on the agri-food sector. After outlining the context, a review of the literature on the relationship between logistics and strategic management in gaining and increasing competitiveness in the agri-food sector is conducted. In particular, the flow of the paper is as follows: after examining the aforementioned managerial problem and its broader repercussions, the paper proceeds to address two main research questions. First, how and by which tools can digitization contribute to improving supply chain management and sustainability in logistics? Second, what are the main managerial and strategic implications and consequences of this for the agri-food sector in terms of efficiency, effectiveness, cost reduction, and supply chain optimization? Finally, the paper presents Italy as a case study, chosen both for its peculiar internal differences in logistical infrastructures and entrepreneurial management between Northern and Southern regions (which could be at least partially overcome with the use of new technologies and frameworks) and for the importance of the agri-food sector for the domestic economy (accounting about 25% of the country’s GDP), on which digitization should have positive effects in terms of value creation and sustainability.
Resolving the Do/Do Not Debate: Communication Perspective to Enhance Sustainable Lifestyles
Authors: Lee Donghee N. , Hutchens Myiah J. , Krieger Janice L.
Published: January 2022

Clear and memorable environmental messaging has been scarce. Recycling contamination is an urgent environmental concern because the public is confused about which items can and cannot be recycled. Environmental campaigns utilizing message framing, a method used to emphasize either the benefits of performing or loss of avoiding an action, may help combat this problem. We conducted an online study (n = 1199) and randomly assigned participants to view positively or negatively framed (do vs. do not) messages. Results revealed that participants who viewed negative messages with do not descriptors increased recycling intention, mediated by increased recycling contamination knowledge and recycling efficacy (95% CI: 0.03, 0.08). The findings suggest that recycling instructions may be more effective when messages are framed negatively using inhibitive descriptors. Results of this study can inform development of environmental campaigns to improve sustainable lifestyles.
Investigation of Pressed Solid Biofuel Produced from Multi-Crop Biomass
Authors: Petlickaitė Rita , Jasinskas Algirdas , Mieldažys Ramūnas , Romaneckas Kęstutis , Praspaliauskas Marius , Balandaitė Jovita
Published: January 2022

The paper presents the preparation and use of pressed solid biofuel of multi-crop plants (fibrous hemp (Cannabis sativa L.), maize (Zea mays L.) and faba bean (Vicia faba L.)) as mono, binary and trinomial crops. The results of the investigation show that three main chemical elements (carbon, oxygen and hydrogen) accounted for 93.1 to 94.9% of the biomass pellet content. The moisture content varied from 3.9 to 8.8%, ash content from 4.5 to 6.8% and calorific value from 16.8 to 17.1 MJ·kg−1. It was found that the density (DM) of all variants of pellets was very similar; the faba bean biomass pellets had the highest density of 1195.8 kg·m−3 DM. The initial ash deformation temperature (DT) of burning biomass pellets was detected, which varied from 976 to 1322 °C. High potassium (K), calcium (Ca) and phosphorus (P) concentrations were found in all types of biomass ash. The quantities of heavy metals in pellet ash were not large and did not exceed the permissible values according to Lithuanian legislation. These chemical properties of multi-crop biomass ash allow them to be used in agriculture for plant fertilization.
The Moderating Effect of Perceived Policy Effectiveness in Residents’ Waste Classification Intentions: A Study of Bengbu, China
Authors: Shen Xin , Chen Bowei , Leibrecht Markus , Du Huanzheng
Published: January 2022

The Chinese government is promoting a waste classification policy to solve the increasingly serious issue of cities being besieged by waste. Only few studies investigate whether residents’ understanding of garbage classification policy has an impact on their garbage classification behaviour and the nature of such impact. The purposes of this study are twofold: first, to explore conceptually the mechanism behind any moderating effects of perceived policy effectiveness (PPE) on waste classification and, second, to examine empirically if and how PPE influences the relationships between attitude (ATT), subjective norm (SN), perceived behaviour control (PBC), awareness of consequence (AC) and waste classification intention (WCI). The conceptual model of the study is developed by combining insights from the theory of planned behaviour, norm activation theory and value–belief–norm theory. A total of 351 questionnaires were administered in person to households in Bengbu, China. The results based on structural equation modelling with partial least squares show that PPE negatively moderates the relationship between AC and WCI. AC is more strongly related with the intention to classify waste when PPE is weaker. Likewise, when PPE is higher, people’s awareness of consequences becomes less important for WCI. The findings have significant implications in policymakers’ developing guidelines and offer a framework for implementing more effective waste classification policy.
Evaluation Method and Application of Ecological Sensitivity of Intercity Railway Network Planning
Authors: Wan Bingtong , Bao Xueying , Zhao Jianchang
Published: January 2022

In the planning stage of the intercity railway network, the ecological sensitivity evaluation of the planning scheme is not only the key content to explore the ecological environmental rationality of the planning scheme but also a scientific means to promote the sustainable development of intercity railway networks. The purpose of this study is to establish an evaluation method that can quantitatively evaluate the ecological sensitivity of intercity railway network planning to put forwards targeted optimization and adjustment suggestions for the planning scheme. Taking the intercity railway network planning of Guizhou Province as an example, its ecological sensitivity is predicted and evaluated. Six types of ecologically sensitive areas were selected as ecological sensitivity evaluation factors, including protected areas, drinking water sources, geological disaster-prone areas, soil erosion areas, cultivated land resource distribution areas and coal resource distribution areas. Based on the GIS overlay method, the quantitative measurement methods of each evaluation factor are established in turn, and the single factor sensitivity evaluation index is obtained. In addition, the weighted superposition model is used to quantitatively calculate the ecological sensitivity of the planned lines of the intercity railway network in Guizhou Province. Finally, the short board factor of each planned line is obtained, and targeted optimization and adjustment suggestions are put forwards. The research content of this paper can provide a theoretical reference for the practical evaluation of the ecological sensitivity of intercity railway network planning.
Determinants of Regional Economic Resilience to Economic Crisis: Evidence from Chinese Economies
Authors: Wang Xiaowen , Li Meiyue
Published: January 2022

The severity of the 2007–2008 economic crisis and the spatial heterogeneity of its impact have accelerated the study of regional economic resilience. The economic crisis has affected most parts of the world, and its impact is highly heterogeneous within China. The aim of this study was to explore the determinants of regional economic resilience across 284 Chinese cities from 2003–2018. Both nation-based and province-based regional economic resilience were examined. A multilevel logistic regression model was established, finding a disparity of provincial effects on regional performance during the economic crisis. Regional economic resilience is significantly affected by provincial trajectories, economy size, and resources. There are five significant determinants of economic resilience: income inequality, innovation, government intervention, human capital, and financial development. The results provide evidence for the government to design region-based policies, taking into consideration the size and the resources of the region’s economy to build a resilient wall to defend against external shocks and to form a basis for sustainable development.
Design and Performance Evaluation of a Step-Up DC–DC Converter with Dual Loop Controllers for Two Stages Grid Connected PV Inverter
Authors: Khan Muhammad Yasir Ali , Liu Haoming , Habib Salman , Khan Danish , Yuan Xiaoling
Published: January 2022

In this work, a non-isolated DC–DC converter is presented that combines a voltage doubler circuit and switch inductor cell with the single ended primary inductor converter to achieve a high voltage gain at a low duty cycle and with reduced component count. The converter utilizes a single switch that makes its control very simple. The voltage stress across the semiconductor components is less than the output voltage, which makes it possible to use the diodes with reduced voltage rating and a switch with low turn-on resistance. In particular, performance principle of the proposed converter along with the steady state analysis such as voltage gain, voltage stress on semiconductor components, and design of inductors and capacitors, etc., are carried out and discussed in detail. Moreover, to regulate a constant voltage at a DC-link capacitor, back propagation algorithm-based adaptive control schemes are designed. These adaptive schemes enhance the system performance by dynamically updating the control law parameters in case of PV intermittency. Furthermore, a proportional resonant controller based on Naslin polynomial method is designed for the current control loop. The method describes a systematic procedure to calculate proportional gain, resonant gain, and all the coefficients for the resonant path. Finally, the proposed system is simulated in MATLAB and Simulink software to validate the analytical and theoretical concepts along with the efficacy of the proposed model.
Technical and Economic Analysis of Modernization of Solar Power Plant: A Case Study from the Republic of Cuba
Authors: Iakovleva Emiliia , Guerra Daniel , Tcvetkov Pavel , Shklyarskiy Yaroslav
Published: January 2022

The problem of increasing the efficiency of existing power plants is relevant for many countries. Solar power plants built at the end of the 20th century require, as their shelf lives have now expired, not only the replacement of the solar modules, but also the modernization of their component composition. This is due to the requirements to improve the efficiency of power plants to ensure the expansion of renewable energy technologies. This article presents a technical and economic analysis of the choice of solar power plant modernization method, which consists of (1) a method for calculating the amount of power generation; (2) the modeling of solar power plants under specific climatic conditions; (3) the analysis of electricity generation using different types of PV modules and solar radiation trapping technologies in Matlab/Simulink; and (4) the technical and economic analysis of a 2.5 MW solar power plant in the Republic of Cuba (in operation since 2015), for which four different modernization options were considered. All the scenarios differ in the depth of modernization; the results of the analysis were compared with the existing plant. The results of the study showed that the different modernization scenarios respond differently to changes in the inputted technical and economic parameters (cost per kWh, inflation rate, losses, and power plant efficiency). The maximum NPV deviations among the considered scenarios are: a 1% increase in inflation reduces NPV by 2%; a decrease in losses from 20% to 10% increases the NPV by 2.5%; a change in cost from EUR 0.05 to EUR 0.1 increases the NPV by more than 3.5 times. The dependence of the economic results was also tested as a function of three factors: solar module efficiency, inflation, and the price per 1 kWh. It was found that the greatest influence on the NPV of the proposed model is the price per 1 kWh. Based on this analysis, an algorithm was developed to choose the most effective scenario for the conditions of the Republic of Cuba for the modernization of the existing power plants.
Mapping Green Infrastructure Based on Multifunctional Ecosystem Services: A Sustainable Planning Framework for Utah’s Wasatch Front
Authors: leBrasseur Richard
Published: January 2022

Most sustainable planning frameworks assess natural and social–economic landscape systems as separate entities, and our understanding of the interrelationships between them is incomplete. Landscape classification in urbanizing environments requires an integrated spatial planning approach to better address the United Nation’s sustainable development challenges. The objective of this research is to apply a multicriteria evaluation which ranked diverse ecosystem–service producing landscapes and synthesize the findings within a unique green infrastructure spatial planning framework. Local government stakeholder derived weighting and GIS classification were operated to map both the urban and natural landscapes of the Salt Lake City region of Utah, one of the most rapidly urbanizing areas in North America. Results were assimilated through five regional landscape typologies—Ecological, Hydrological, Recreational, Working Lands, and Community—and indicated those highest ranked landscape areas which provided multiple ecosystem services. These findings support collaborative decision making among diverse stakeholders with overlapping objectives and illustrates pathways to the development of ecosystem service criteria. This paper contributes to a better understanding of how to integrate data and visualize the strategic approaches required for sustainable planning and management, particularly in urban and urbanizing regions where complex socioecological landscapes predominate.
Place-Specific Corona Dashboards for Health Policy: Design and Application of a ‘Dutchboard’
Authors: Nijkamp Peter , Kourtit Karima
Published: January 2022

Since the outbreak of the corona virus in the end of 2019, many worldwide attempts have been made to monitor and control the COVID-19 pandemic. A wealth of empirical data has been collected and used by national health authorities to understand and mitigate the spread and impacts of the corona virus. In various countries this serious health concern has led to the development of corona dashboards monitoring the COVID-19 evolution. The present study aims to design and test an extended corona dashboard, in which—beside up-to-date daily core data on infections, hospital and intensive care admissions, and numbers of deceased people—also the evolution of vaccinations in a country is mapped out. This dashboard system is next extended with time-dependent contextual information on lockdown and policy stringency measures, while disaggregate information on the geographic spread of the COVID-19 disease is provided by means of big data on contact intensity and mobility motives based on detailed Google Mobility data. Finally, this context-specific corona dashboard, named ‘Dutchboard’, is further extended towards the regional and local level so as to allow also for space-specific ‘health checks’ and assessments.
Assessment of Soil Physical Quality and Water Flow Regulation under Straw Removal Management in Sugarcane Production Fields
Authors: Lustosa Carvalho Martha , Bonini da Luz Felipe , de Lima Renato Paiva , Cavalieri-Polizeli Karina Maria Vieira , Carvalho João Luís Nunes , Cherubin Maurício Roberto
Published: January 2022

Removing sugarcane straw to increase bioenergy production can generate significant income to the industry. However, straw contributes to the regulation of soil functions and consequently supports the provision of ecosystem services, such as water flow regulation. Thus, straw removal may hinder the provision of these services, especially in mechanized sugarcane production systems, which have soil compaction problems due to machinery traffic. In this study, we assess a six-year experiment in Brazil with four rates of straw removal: 0 Mg ha−1 (TR), 5 Mg ha−1 (HR), 10 Mg ha−1 (LR), and 15 Mg ha−1 (NR) remaining straw. Using attributes, such as soil bulk density, porosity, water infiltration, runoff, saturated hydraulic conductivity and available water-holding capacity, as indicators of key soil functions, we calculated a soil-related ecosystem service (ES) index for water flow regulation provision. The ES index revealed that water flow regulation was low regardless of the straw management (0.56, 0.63, 0.64 and 0.60 for TR, HR, LR and NR, respectively). It can be a consequence of soil compaction caused by machinery traffic throughout the successive cycle, whose straw was unable to mitigate this issue. Thus, by the end of the sugarcane cycle (sixth ratoon), straw removal had little effect on soil physical and hydraulic indicators, and consequently had little impact on the provision of the soil-related ES associated with water flow regulation. Nevertheless, straw management should be planned to consider other functions and soil-related ES benefited by straw retention.
Circular Economy Impact Analysis on Stock Performances: An Empirical Comparison with the Euro Stoxx 50® ESG Index
Authors: Morea Donato , Mango Fabiomassimo , Cardi Mavie , Paccione Cosimo , Bittucci Lucilla
Published: January 2022

Environmental issues have a considerable impact in all economic sectors, also influencing financial markets. As a result, environmental, social, and governance (ESG) awareness is rising in the financial sector. In this perspective, the concept of circular economy (CE) assumes central relevance. The aim of our study is to investigate the relationship between CE strategies and market performance; to this end, we use ESG scores as a proxy for CE. Our initial assumption is that since CE is a component of the “E” factor—in that it can generate positive and measurable environmental impacts—then it can be associated with the ESG score. Therefore, we can methodologically overcome the lack of a specific score related to CE. We use a preselection model based on historical performance by verifying the percentages of the presence of stocks in the two selected indices, namely ESG Euro Stoxx 50® and Euro Stoxx 50-ESG. Overall, we find that ESG profiles have a positive impact on stock performance, although ESG scores do not express higher performance per se. Furthermore, our analysis shows that, to date, there is no evidence that CE initiatives can influence stock returns.
A Nonstandard Finite Difference Method for a Generalized Black–Scholes Equation
Authors: Mehdizadeh Khalsaraei Mohammad , Rashidi Mohammad Mehdi , Shokri Ali , Ramos Higinio , Khakzad Pari
Published: January 2022

An implicit finite difference scheme for the numerical solution of a generalized Black–Scholes equation is presented. The method is based on the nonstandard finite difference technique. The positivity property is discussed and it is shown that the proposed method is consistent, stable and also the order of the scheme respect to the space variable is two. As the Black–Scholes model relies on symmetry of distribution and ignores the skewness of the distribution of the asset, the proposed method will be more appropriate for solving such symmetric models. In order to illustrate the efficiency of the new method, we applied it on some test examples. The obtained results confirm the theoretical behavior regarding the order of convergence. Furthermore, the numerical results are in good agreement with the exact solution and are more accurate than other existing results in the literature.
Energetic and Geometric Characteristics of Substituents, Part 3: The Case of NO2 and NH2 Groups in Their Mono-Substituted Derivatives of Six-Membered Heterocycles
Authors: Wieczorkiewicz Paweł A. , Szatylowicz Halina , Krygowski Tadeusz M.
Published: January 2022

Substituted heterocyclic arenes play important roles in biochemistry, catalysis, and in the design of functional materials. Exemplary six-membered heteroaromatic molecules, that differ from benzene by inclusion of one heteroatom, are pyridine, phosphorine, arsabenzene, and borabenzene. This theoretical study concerns the influence of the heteroatom present in these molecules on the properties of substituents of two types: electron-donating (ED) NH2 group and electron-accepting (EA) NO2 group, attached at the 2-, 3-, or 4-position. The effect is evaluated by the energy of interaction (Erel) between the substituent and the substituted system and electronic properties of the substituents described by the charge of the substituent active region (cSAR) index. In addition, several geometric descriptors of the substituent and heteroaromatic ring, as well as changes in the aromaticity, are considered. The latter are assessed using the Electron Density of Delocalized Bonds (EDDBs) property of delocalized π electrons. The obtained results show that the electronegativity (EN) of the heteroatom has a profound effect on the EA/ED properties of the substituents. This effect is also reflected in the geometry of studied molecules. The Erel parameter indicates that the relative stability of the molecules is highly related to the electronic interactions between the substituent and the heteroarene. This especially applies to the enhancement or weakening of π-resonance due to the EN of the heteroatom. Additionally, in the 2-heteroarene derivatives, specific through-space ortho interactions contribute to the heteroatom effects.
A Simulated Environment for Robot Vision Experiments
Authors: Sevastopoulos Christos , Konstantopoulos Stasinos , Balaji Keshav , Zaki Zadeh Mohammad , Makedon Fillia
Published: January 2022

Training on simulation data has proven invaluable in applying machine learning in robotics. However, when looking at robot vision in particular, simulated images cannot be directly used no matter how realistic the image rendering is, as many physical parameters (temperature, humidity, wear-and-tear in time) vary and affect texture and lighting in ways that cannot be encoded in the simulation. In this article we propose a different approach for extracting value from simulated environments: although neither of the trained models can be used nor are any evaluation scores expected to be the same on simulated and physical data, the conclusions drawn from simulated experiments might be valid. If this is the case, then simulated environments can be used in early-stage experimentation with different network architectures and features. This will expedite the early development phase before moving to (harder to conduct) physical experiments in order to evaluate the most promising approaches. In order to test this idea we created two simulated environments for the Unity engine, acquired simulated visual datasets, and used them to reproduce experiments originally carried out in a physical environment. The comparison of the conclusions drawn in the physical and the simulated experiments is promising regarding the validity of our approach.
Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography
Authors: Ulfik-Dembska Klaudia , Teper Sławomir , Dembski Michał , Nowińska Anna , Wylęgała Edward
Published: January 2022

Background: The present study examined the relationships among macular microvasculature, retinal structure, and epiretinal membrane (ERM) and explored the utility of optical coherence tomography (OCT) angiography (OCTA) in idiopathic ERM assessment. Methods: The study sample comprised 276 eyes of 276 patients. A total of 154 eyes with ERM and 122 normal (control) eyes were analyzed. Only one eye of each participant was randomly selected for posterior segment imaging. Each patient underwent OCT and OCTA. Images were analyzed with AngioTool 0.6. Results: Foveal avascular zone was significantly smaller in the ERM group (p = 0.044). Average retinal thickness and foveal thickness were significantly higher in the ERM group (both p = 0.001). Moreover, 64 (41.5%) patients exhibited no metamorphopsia, while 46 (29.8%) and 44 (28.7%) patients exhibited moderate and extensive metamorphopsias, respectively. Meanwhile, FAZ was negatively correlated with central retinal thickness in the ERM group. The vessel area (p = 0.0017) and vessel percentage area (p = 0.044) were significantly greater in the ERM group. Conclusions: Changes observed in the superficial plexus in OCTA are related to the severity of metamorphopsia and can be further evaluated to support decision making regarding the surgical management of idiopathic ERM.
Two Hits of EDCs Three Generations Apart: Effects on Social Behaviors in Rats, and Analysis by Machine Learning
Authors: Gillette Ross , Dias Michelle , Reilly Michael P. , Thompson Lindsay M. , Castillo Norma J. , Vasquez Erin L. , Crews David , Gore Andrea C.
Published: January 2022

All individuals are directly exposed to extant environmental endocrine-disrupting chemicals (EDCs), and indirectly exposed through transgenerational inheritance from our ancestors. Although direct and ancestral exposures can each lead to deficits in behaviors, their interactions are not known. Here we focused on social behaviors based on evidence of their vulnerability to direct or ancestral exposures, together with their importance in reproduction and survival of a species. Using a novel “two hits, three generations apart” experimental rat model, we investigated interactions of two classes of EDCs across six generations. PCBs (a weakly estrogenic mixture Aroclor 1221, 1 mg/kg), Vinclozolin (antiandrogenic, 1 mg/kg) or vehicle (6% DMSO in sesame oil) were administered to pregnant rat dams (F0) to directly expose the F1 generation, with subsequent breeding through paternal or maternal lines. A second EDC hit was given to F3 dams, thereby exposing the F4 generation, with breeding through the F6 generation. Approximately 1200 male and female rats from F1, F3, F4 and F6 generations were run through tests of sociability and social novelty as indices of social preference. We leveraged machine learning using DeepLabCut to analyze nuanced social behaviors such as nose touching with accuracy similar to a human scorer. Surprisingly, social behaviors were affected in ancestrally exposed but not directly exposed individuals, particularly females from a paternally exposed breeding lineage. Effects varied by EDC: Vinclozolin affected aspects of behavior in the F3 generation while PCBs affected both the F3 and F6 generations. Taken together, our data suggest that specific aspects of behavior are particularly vulnerable to heritable ancestral exposure of EDC contamination, that there are sex differences, and that lineage is a key factor in transgenerational outcomes.
Potentially Toxic Substances and Associated Risks in Soils Affected by Wildfires: A Review
Authors: Fernandez-Marcos Maria Luisa
Published: January 2022

The presence of toxic substances is one of the major causes of degradation of soil quality. Wildfires, besides affecting various chemical, physical, and biological soil properties, produce a mixture of potentially toxic substances which can reach the soil and water bodies and cause harm to these media. This review intends to summarise the current knowledge on the generation by wildfires of potentially toxic substances, their effects on soil organisms, and other associated risks, addressing the effects of fire on metal mobilisation, the pyrolytic production of potentially toxic compounds, and the detoxifying effect of charcoal. Numerous studies ascertained inhibitory effects of ash on seed germination and seedling growth as well as its toxicity to soil and aquatic organisms. Abundant publications addressed the mobilisation of heavy metals and trace elements by fire, including analyses of total concentrations, speciation, availability, and risk of exportation to water bodies. Many publications studied the presence of polycyclic aromatic hydrocarbons (PAH) and other organic pollutants in soils after fire, their composition, decline over time, the risk of contamination of surface and ground waters, and their toxicity to plants, soil, and water organisms. Finally, the review addresses the possible detoxifying role of charcoal in soils affected by fire.
BoNT/A in the Urinary Bladder—More to the Story than Silencing of Cholinergic Nerves
Authors: Ibrahim Hodan , Maignel Jacquie , Hornby Fraser , Daly Donna , Beard Matthew
Published: January 2022

Botulinum neurotoxin (BoNT/A) is an FDA and NICE approved second-line treatment for overactive bladder (OAB) in patients either not responsive or intolerant to anti-cholinergic drugs. BoNT/A acts to weaken muscle contraction by blocking release of the neurotransmitter acetyl choline (ACh) at neuromuscular junctions. However, this biological activity does not easily explain all the observed effects in clinical and non-clinical studies. There are also conflicting reports of expression of the BoNT/A protein receptor, SV2, and intracellular target protein, SNAP-25, in the urothelium and bladder. This review presents the current evidence of BoNT/A’s effect on bladder sensation, potential mechanisms by which it might exert these effects and discusses recent advances in understanding the action of BoNT in bladder tissue.
Outer Membrane Vesicles (OMVs) of Pseudomonas aeruginosa Provide Passive Resistance but Not Sensitization to LPS-Specific Phages
Authors: Augustyniak Daria , Olszak Tomasz , Drulis-Kawa Zuzanna
Published: January 2022

Outer membrane vesicles (OMVs) released from gram-negative bacteria are key elements in bacterial physiology, pathogenesis, and defence. In this study, we investigated the role of Pseudomonas aeruginosa OMVs in the anti-phage defence as well as in the potential sensitization to LPS-specific phages. Using transmission electron microscopy, virion infectivity, and neutralization assays, we have shown that both phages efficiently absorb on free vesicles and are unable to infect P. aeruginosa host. Nevertheless, the accompanying decrease in PFU titre (neutralization) was only observed for myovirus KT28 but not podovirus LUZ7. Next, we verified whether OMVs derived from wild-type PAO1 strain can sensitize the LPS-deficient mutant (Δwbpl PAO1) resistant to tested phages. The flow cytometry experiments proved a quite effective and comparable association of OMVs to Δwbpl PAO1 and wild-type PAO1; however, the growth kinetic curves and one-step growth assay revealed no sensitization event of the OMV-associated phage-resistant P. aeruginosa deletant to LPS-specific phages. Our findings for the first time identify naturally formed OMVs as important players in passive resistance (protection) of P. aeruginosa population to phages, but we disproved the hypothesis of transferring phage receptors to make resistant strains susceptible to LPS-dependent phages.
Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal Antibody
Authors: Thavorasak Techit , Chulanetra Monrat , Glab-ampai Kittirat , Teeranitayatarn Karsidete , Songserm Thaweesak , Yodsheewan Rungrueang , Sae-lim Nawannaporn , Lekcharoensuk Porntippa , Sookrung Nitat , Chaicumpa Wanpen
Published: January 2022

Porcine epidemic diarrhea virus (PEDV) causes devastating enteric disease that inflicts huge economic damage on the swine industry worldwide. A safe and highly effective PEDV vaccine that contains only the virus-neutralizing epitopes (not enhancing epitope), as well as a ready-to-use PEDV neutralizing antibody for the passive immunization of PEDV vulnerable piglets (during the first week of life) are needed, particularly for PEDV-endemic farms. In this study, we generated monoclonal antibodies (mAbs) to the recombinant S1 domain of PEDV spike (S) protein and tested their PEDV neutralizing activity by CPE-reduction assay. The mAb secreted by one hybrodoma clone (A3), that also bound to the native S1 counterpart from PEDV-infected cells (tested by combined co-immunoprecipitation and Western blotting), neutralized PEDV infectivity. Epitope of the neutralizing mAb (mAbA3) locates in the S1A subdomain of the spike protein, as identified by phage mimotope search and multiple sequence alignment, and peptide binding-ELISA. The newly identified epitope is shared by PEDV G1 and G2 strains and other alphacoronaviruses. In summary, mAbA3 may be useful as a ready-to-use antibody for passive immunization of PEDV-susceptible piglets, while the novel neutralizing epitope, together with other, previously known protective epitopes, have potential as an immunogenic cocktail for a safe, next-generation PEDV vaccine.
Vaccination against COVID-19: Factors That Influence Vaccine Hesitancy among an Ethnically Diverse Community in the UK
Authors: Cook Erica Jane , Elliott Elizabeth , Gaitan Alfredo , Nduka Ifunanya , Cartwright Sally , Egbutah Chimeme , Randhawa Gurch , Waqar Muhammad , Ali Nasreen
Published: January 2022

The UK’s minority ethnic population, despite being at higher risk of COVID-19 and experiencing poorer health outcomes, continue to have lower uptake of the COVID-19 vaccine compared with their white British counterparts. Given the importance of the vaccination programme in improving health outcomes, this research sought to examine the influential factors that impact the decision to accept the COVID-19 vaccination among an ethnically diverse community. A total of 1058 residents from Luton, UK, a large town with an ethnically diverse population, completed a community survey. Questions centred around uptake or individuals’ intentions to accept the offer of COVID-19 vaccination alongside demographics, knowledge, and views on the vaccine. A binary logistic regression analysis was conducted to determine the most significant predictors of vaccine hesitancy, while respondents’ reasons for not getting vaccinated were identified using qualitative content analysis. Findings revealed that age and ethnicity were the only sociodemographic factors to predict vaccine hesitancy. Knowledge of symptoms and transmission routes, alongside ensuring information about COVID-19 was objectively sourced, were all identified as protective factors against vaccine hesitancy. Qualitative analysis revealed that ‘lack of trust in government/authorities’ and ‘concern of the speed of vaccine development’ were the most common reasons for non-uptake. This research reinforces the importance of age, ethnicity, and knowledge as influential factors in predicting vaccine hesitancy. Further, this study uncovers some of the barriers of uptake that can be utilised in developing promotional campaigns to reduce vaccine hesitancy in certain sections of the diverse UK population.
Side Effects and Efficacy of COVID-19 Vaccines among the Egyptian Population
Authors: Elgendy Marwa O. , El-Gendy Ahmed O. , Mahmoud Sarah , Mohammed Tarek Yehia , Abdelrahim Mohamed E. A. , Sayed Ahmed M.
Published: January 2022

Background: Knowledge about a vaccine’s side effects and efficacy is important to improving public vaccine acceptance. This study aimed to detect the safety and efficacy of vaccines among the Egyptian population. Methodology and Results: Data was collected using an online survey from participants who took two doses of the BBIBP-CorV, ChAdOx1, or BNT162 vaccines. Pain at the vaccine injection site, muscle pain, fatigue, dizziness, fever, and headache were the most common side effects after the first and second doses. The number pf side effects was higher in ChAdOx1 than in BNT162 and BBIBP-CorV. Most of the side effects started on the first day after vaccination and persisted for 1–2 days. Vaccinated people with past coronavirus infections before vaccination developed better antibodies than those who were only vaccinated. The side-effect severity was greater after the first dose of BBIBP-CorV and ChAdOx1 than after the second dose, but in contrast, the side-effect severity was greater after the second dose of BNT162 vaccine than after the first dose. ChAdOx1 was more effective than BBIBP-CorV, and one dose of ChAdOx1 produced an immune response similar to that of two doses of BBIBP-CorV. Conclusions: Coronavirus vaccines were well-tolerated, safe, and produced an immune response against the virus in most cases. Most postvaccine side effects were mild to moderate, which indicated the building of immunity by the body for protection.