bluuebunny/crossref_metadata_2025 huggingface dataset:
Professionalism of the head of the institution of general secondary education as the basis of his highl y efficient management activity
Authors:   Kamyanets-Podilsky Ivan Ohienko National University, Polishchuk Svitlana
Published: August 2022

Автор статті на основі проведеного ним дослідження вказує на важливість професіоналізму керівника закладу загальної середньої освіти в його управлінській діяльності. В статті на високому науково-педагогічному рівні розкриті зміст та значення професіоналізму. Звертається увага на актуальність лідерських задатків керівника, які безпосередньо впливають на зростання його професійної майстерності, його інтелект і рівень компетентності. Ключовим питанням статті є висвітлення проблем розвитку та становлення професіоналізму керівника (менеджера). Важливим моментом є обґрунтування автором порядку визначення кваліфікаційного рівня керівника. У статті велика увага приділена особистісним якостям керівника, які в тій чи іншій мірі впливають на формування його професіоналізму. Крім цього автор підкреслює важливість встановлення системи показників для визначення ефективності управлінської діяльності керівника (менеджера) закладу, вказує на необхідність оцінювання виконуваної ним роботи. Важливим моментом статті є те, що її автор вказує на доцільність створення цілісної картини вдосконалення системи управління сучасними закладами освіти й підвищення ролі керівника закладу загальної середньої освіти як фахівця. При цьому звертається увага на необхідність формування нової системи управління, на баченні її пріоритетних напрямів. У статті вказується на важливість наявності у сфері освіти менеджера-новатора, який володіє високим рівнем знань, умінь і навичок, має відповідний рівень якісної й ефективної підготовленості, управлінського мислення, творчий і моральний потенціал. Автор підкреслює, що сучасним закладам загальної середньої освіти необхідний керівник нової генерації, який би був здатний у процесі безперервної освіти його особистісно-професійного розвитку забезпечити високий рівень конкурентоздатності ввіреного йому закладу. Виходячи із змісту статті, автор робить чіткі, науково обґрунтовані висновки та пропонує конкретні рекомендації, які сприятимуть підвищенню ефективності діяльності керівника закладу загальної середньої освіти в умовах реформування вітчизняної освітньої системи.
Ukrainian pedagogues of the 19th century: contribution to modern pedagogy
Authors:   National University of Ukraine on Physical Education and Sport, Babushko Svitlana , Halytska Maiia ,   National University of Ukraine on Physical Education and Sport, Rekun Nataliia ,   National University of Ukraine on Physical Education and Sport
Published: August 2022

The article aims at revealing the contribution of 19th century Ukrainian pedagogues to the development of pedagogy as a science. The most prominent cultural figures of that time and their pedagogical legacy were under the consideration from the following aspects: their social and pedagogical activity; peculiar features of their pedagogical theories; their impact on the development of pedagogical ideas in forthcoming centuries. To achieve it, there were used methods of historiography, identification, analysis and systematization. The choice of the 19th century was determined by its great educational role in the social life which was reflected in its name “Enlightenment”. The lack of native land, national identity, integrity of Ukrainians as a people did not prevent the intellectual elite of the nation to search the ways of cultural unity and revival. The effective tool in it was the introduction of national education into masses of people. In their educational activity they applied the didactic principles: visibility of learning, conscious and active learning, consecutive and systematic learning, firmness of knowledge acquisition, connection with real life, the use of both synthetic and analytical methods of learning and teaching. The research proved that Ukrainian pedagogy was developing according to the major European trends in education, e.g. secularization of education, attention to family education, expanding the content of general education. Yet, there were unique national pedagogical ideas of using the Ukrainian language, a mother tongue, for teaching Ukrainian children; introducing Ukrainian folklore into the educational process; liquidating the class inequality; nursing the child’s soul. Their achievements are still important today. Addressing the origins of Ukrainian pedagogy can assist in achieving the goal of educating and upbringing younger generation who respects their native land and tries to preserve their history. Thus, the argument of the outmost importance in this research is that the current state of modern pedagogy greatly depends on its historical background.
Investigating the Washback Effects of TOEFL iBT on the Preparation Courses of the Training Institutions in Shanghai
Authors: Zhang Yangyang , Li Le , Miao Dejun
Published: August 2022

This research probes into the washback effects of TOEFL iBT (the Test of English as a Foreign Language Internet-Based Test) and how teachers in the training institutions instruct preparation course in Shanghai. The findings in this article show that teachers are supposed to transform the general language skills into teachable materials and need to be more aware of cross-cultural learning problems. The study points out that the TOEFL iBT has an influence both on course materials and teaching methodology. However, the effects can be intervened by using appropriate TOEFL iBT preparation materials.
Digital Logistics Transformation. Logistics 4.0 as a Risk Minimization Tool
Authors: Zhukov N. S. , Karanina E. V.
Published: August 2022

This study aims to investigate the risks faced by today’s logistics industry and describes the Logistics 4.0 concept as a tool for minimizing these risks. The study conducts a literary review of modern research on the topics “Industry 4.0,” “Logistics 4.0,” and examines the relevant definitions. The study aims to form a theoretical framework and study current methodological research to form a basis for further research of “maturity models” of companies.
Analysis of the Practice and Risks of Using Infrastructure Bonds in the Project Financing Market
Authors: Shemyakina T.  Yu. , Churkina A. A. , Fedorova P. A.
Published: August 2022

The article discusses the role and features of project financing of facilities, the need for new instruments and forms of attracting investments that would allow linking debt obligations with the project being implemented. Financial sources of construction of facilities within the framework of public-private partnership are investigated. It has been established that the relevance of the use of infrastructure bonds is confirmed by the lack of financial resources for infrastructure projects, as well as the growing market for non-mandatory pension insurance. It is noted that only the conditions necessary for the targeted use of funds received from the sale of infrastructure bonds and the rules for financing the construction and reconstruction of infrastructure facilities using SOPF bonds are fixed at the legislative level. The goals of creating infrastructure bonds have been determined. The analysis of the ratio of the application of loans and bonds in project financing was carried out, the stages of project financing are considered. Municipal targeted and corporate forms of issuing infrastructure bonds were identified and the main conditions for financing infrastructure projects were formulated. It is noted that despite the fact that infrastructure bonds are reliable, it is necessary to increase their protection against inflation and indicate a competitive yield on securities compared to federal loan bonds. Additional measures are proposed to increase the attractiveness of the infrastructure project. It is noted that an important condition for the completion of infrastructure projects is the effective distribution of risks and effective management of them. Financial, political and project assessment risks were identified as the main risks. The latter are classified as mandatory monitoring and control, since they affect the incompleteness of the project. The advantages and disadvantages of this project financing mechanism are formulated.
Cordia verbenacea DC Boraginaceae
Authors: Gilbert Benjamin , Favoreto Rita
Published: August 2022

As partes aéreas de Cordia verbenacea são usadas tradicionalmente como um antiinflamatório. A base científica deste uso é descrita em termos de botânica, farmacognosia, farmacologia e toxicologia visando o desenvolvimento de um medicamento fitoterápico.
Avaliação da Administração Crônica de Mucuna pruriens sobre Parâmetros Bioquímicos e Hematológicos e de seus Efeitos Neuroprotetores, em Modelo de Doença de Parkinson
Authors: Lopes Amanda A. , Pereira Fábio A. , Queiroz Maria G. , Pitombeira Márcia V. , Leal Luzia K. A. M. , Viana Glauce S. B.
Published: August 2022

A doença de Parkinson (DP) é uma patologia neurodegenerativa caracterizada pela perda progressiva de neurônios dopaminérgicos na substância negra. Os sinais cardinais da doença são bradicinesia, tremor de repouso e instabilidade postural. É a segunda doença neurodegenativa mais comum, após a doença de Alzheimer. Os tratamentos disponíveis são apenas sintomáticos, não evitando a progressão da doença, e a L-DOPA, considerada padrão-ouro, apresenta efeitos colaterais sendo a discinesia um dos mais sérios. Mucuna pruriens é utilizada na medicina tradicional, principalmente na Índia, para o tratamento de DP. Essa espécie contém entre os seus constituintes bioativos a L-DOPA e parece apresentar um potencial discinésico menor do que aquele da L-DOPA sintética. No presente trabalho, observou-se que a administração de L-DOPA durante 14 dias aumenta as concentrações de dopamina no estriato, após a lesão unilateral por 6-OHDA em ratos. Nas doses usadas (50 e 100mg/kg, p.o.), equivalentes a 25 e 50 mg/kg de L-DOPA, nenhuma alteração foi observada nos níveis de NE, 5-HT ou de seu metabólito 5-HIAA. Além disso, nenhuma alteração significativa foi demonstrada nos parâmetros bioquímicos ou hematológicos, após administração crônica de M. pruriens, nas doses de 250, 500 e 1000 mg/kg durante 90 dias. Os resultados são indicativos de efeitos neuroprotetores e confirmam o potencial benéfico de M. pruriens no tratamento de DP.
Exploração de Bioativos: Parcerias e Patentes
Authors: Gutiérrez Ingrid E.M. , Góes-Neto Aristóteles
Published: August 2022

Este estudo objetivou avaliar o nível de parcerias e patentes brasileiras acerca de produtos naturais no setor empresarial e acadêmico, e então relacioná-lo com o panorama de investimentos e recursos humanos destinados a área de Química, Farmácia e Biotecnologia no país, que são imprescindíveis para as atividades de bioprospecção com o objetivo de descobrir princípios ativos de interesse para a saúde humana a partir da biodiversidade. O levantamento foi realizado nos bancos públicos de patentes do Brasil, Estados Unidos e Europa e nos sites dos órgãos de fomento à pesquisa e recursos humanos no país. Fica evidente a necessidade de incentivarmos a cultura da patenteabilidade por parte da academia e empresa nacionais, no tocante a produtos e processos advindos da biodiversidade, tornando-se imprescindível uma mudança brusca na atual legislação que regulamenta o seu acesso, assim como uma maior aproximação do setor empresarial com o acadêmico.
Pesquisa e Desenvolvimento de Fitoterápicos: Relatos de Experiência em Indústria Farmacêutica Nacional
Authors: Marques Luis C. , Souza Carlos M.
Published: August 2022

Relata-se experiência profissional de cinco anos em uma empresa farmacêutica brasileira. Nesse período, montou-se uma equipe técnica e buscou-se o desenvolvimento de uma linha fitoterápica a partir de literatura científica, aproveitamento de estudos nacionais já realizados bem como com ajustes de pesquisas internacionais ao padrão regulatório brasileiro. Como resultados desta atividade profissional foram desenvolvidos cinco fitoterápicos: cápsulas duras com extrato de isoflavonas agliconas de soja (Glycine max), resultado de parceria com outra empresa e universidade; comprimidos de extrato padronizado de incenso (Boswellia serrata) indicados em patologias inflamatórias intestinais; comprimidos de extrato padronizado de garra do diabo (Harpagophytum procumbens) indicados em patologias reumáticas; cápsulas gelatinosas moles com óleo essencial de hortelã-pimenta (Mentha piperita) recomendadas na fase espástica da síndrome do intestino irritável; e, por fim, pomada com extrato padronizado das cascas de barbatimão (Stryphnodendron adstringens) indicada como cicatrizante em escaras de graus I e II. Apesar das dificuldades e complexidade de cumprimento dos requisitos da cadeia de pesquisa e desenvolvimento, o presente relato mostra ser possível esta atividade, com geração de produtos fitoterápicos seguros, eficazes e de qualidade compatível com as exigências regulatórias nacionais e internacionais.
Marketing esportivo no futebol: ações de marketing no Clube de Regatas Flamengo no ano de 2019
Authors: Bartolazzi Victor Tomazinho , Bessa Pedro Lincoln Bastos , Azevedo Filho Edson Terra , Medeiros Carlos Henrique de Souza
Published: August 2022

Estratégias, ações e campanhas de marketing estão cada vez mais atraindo marcas de grande nome para o meio esportivo, assim, percebe-se que o cenário brasileiro no futebol começa a atentar-se à importância do marketing dentro dos clubes, tendo o Flamengo um dos primeiros times a desenvolver resultados positivos auxiliado pelas redes sociais. Assim, esta pesquisa trouxe a seguinte questão norteadora: como as ações de marketing do Flamengo puderam contribuir para o engajamento do clube com seu torcedor? Sendo assim, este trabalho tem o objetivo geral de analisar e identificar os resultados das ações de marketing esportivo praticadas pelo Clube de Regatas do Flamengo no ano de 2019. Para alcançar os resultados, observou-se as ações de marketing praticadas nas redes sociais no ano de 2019. Percebeu-se que os números do clube superaram a marca alcançada pelos times River Plate e Boca Júnior juntos. O time possui diariamente postagens de interesse do torcedor, o que produz maior engajamento nas redes e aumento da interação entre o Flamengo e seu torcedor.
Social-Geographical Patterns of Rescue Requests During Hurricane Harvey
Authors: Feng Kairui , Shao Wanyun , Lin Ning
Published: August 2022

We analyze a public dataset of rescue requests for the Houston Metropolitan Area during Hurricane Harvey (2017) from the Red Cross. This dataset contains information including the location, gender, and emergency description in each requester’s report. We reveal the spatial distribution of the rescue requests and its relationship with indicators of the social, physical, and built environment. We show that the rescue request rates are significantly higher in regions with higher percentages of children, male population, population in poverty, or people with limited English, in addition to regions with higher inundation rate or worse traffic condition during Hurricane Harvey. The rescue request rate is found to be statistically uncorrelated with the percentage of flood hazard zone designated by the Federal Emergency Management Agency (FEMA).
Analisis Perbedaan Hasil Belajar pada Pembelajaran Matematika Secara Daring dan Luring Siswa Kelas V SDN Tegal Alur 21 Petang
Authors: Fitria Mellynda Nurul , Sukmawati Wati
Published: August 2022

Learning that has been carried out online during the Covid-19 pandemic, especially in Indonesia, is now with conditions starting to stabilize, the government has allowed learning to take place offline or face-to-face, this of course creates problems for the world of education. This research was conducted with the aim of being able to answer questions in an empirical form on the differences between online learning and offline learning in mathematics subjects with the volume of geometric figures seen on student learning outcomes. The method applied to the research is descriptive quantitative approach, while the students who are used as samples in this study are class V students. From the research that has been successfully completed, the data is obtained through instrument tests and interviews with students and teachers, this research was conducted as an evaluation of online and offline learning during the pandemic and post-pandemic.. The results of the study found that students have an average value of online learning that is greater than offline learning. In the results of hypothesis testing it was found that  is 4,910 greater than  is 4,10, so there are significant results, that there is a difference in learning outcomes in online learning and offline learning. This is also increasingly supported by the results of interviews that have been conducted with students and teachers.

 

Pembelajaran yang telah dilakukan secara daring ketika adanya pandemi covid-19 terutama di Indonesia, kini dengan kondisi yang mulai stabil, pemerintah mengizinkan kembali pembelajaran berlangsung secara luring atau tatap muka. Hal ini tentunya menimbulkan permasalahan bagi dunia pendidikan. Penelitian ini dilakukan dengan tujuan agar dapat menjawab pertanyaan dalam bentuk empiris terhadap perbedaan pembelajaran daring dengan pembelajaran luring pada mata pelajaran matematika materi volume bangun ruang dilihat terhadap hasil belajar siswa. Metode yang diterapkan pada penelitian yaitu metode deskriptif pendekatan secara kuantitatif, adapun siswa yang dijadikan sebagai sampel dalam penelitian ini adalah siswa kelas V. Dari penelitian yang sudah berhasil diselesaikan data didapatkan melalui tes instrumen soal dan wawancara kepada siswa dan guru, penelitian ini dilakukan sebagai evaluasi terhadap pembelajaran daring dan luring semasa pandemi dan pasca pandemi. Hasil penelitian ditemukan siswa memiliki rata-rata pada nilai pembelajaran daring lebih besar daripada pembelajaran secara luring. Pada hasil uji hipotesis ditemukan bahwa sebesar 4,910 lebih besar dari  4,10, maka terdapat hasil yang signifikan, bahwa adanya perbedaan dari hasil belajar pada pembelajaran secara daring dengan pembelajaran secara luring. Hal tersebut juga semakin di dukung atas hasil wawancara yang telah di lakukan kepada siswa dan guru.
Hubungan Literasi Sains dengan Keterampilan Proses Sains pada Peserta Didik Kelas V di Sekolah Dasar
Authors: Danianty Nabila , Sari Prima Mutia
Published: August 2022

The aim of research was to know the correlation between science literacy and science process skill on 5th grade students in the elementary school. The research method using quantitative with correlational. The population and sample was students 5th grade consisted of 40 students. The data collection technique with test and data analytical technique used Spearman Rank. Based on the results of the research can be concluded, that there is a significant correlation between science literacy and science process skill on 5th grade students at SDN Jatisampurna III. The results Spearman rank correlation test of 0.490 with a significant value of 0.001 < 0.05.

Penelitian ini bertujuan untuk mengetahui apakah ada hubungan antara literasi sains dengan keterampilan proses sains pada peserta didik kelas V di sekolah dasar. Metode penelitian menggunakan kuantitatif dengan korelasional. Populasi dan sampel adalah peserta didik kelas V sebanyak 40 orang. Teknik pengumpulan data dengan tes dan teknik analisis data yang digunakan korelasi Spearman Rank. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat hubungan yang signifikan antara literasi sains dengan keterampilan proses sains pada peserta didik kelas V di SDN Jatisampurna III. Dengan hasil uji korelasi spearman rank sebesar 0,490 dengan nilai signifikan 0,001< 0,05.
Computational fluid dynamic simulation of laminar flow over a flat plate
Authors: Klazly Mohamad Mehi Alddin , Bognár Gabriella
Published: August 2022

The aim of this work is to apply CFD simulation on airflow over a flat plate to study the problem of hydrodynamic and thermal boundary layer and to analyse the effect of the length of the plate. The simulation ANSYS Fluent R18.1 has been applied to solve the governing equations of the flow. The simulation results have been verified by comparing the numerical solution with the analytical solution. The effect of changing the length of the plate is investigated while the other quantities were considered constant such as the free stream velocity, density, viscosity and temperature. The result showed excellent agreement between the numerical solution and analytical solution with maximum error of less than 6.19%. It is obtained that as the plate length increases the maximum value of the velocity contour, the Nusselt number, the wall shear stress, the skin friction coefficient and drag coefficient decreases.
The Application of Artificial Intelligence Technologies in Digital Humanities: Applying to Dunhuang Culture Inheritance, Development, and Innovation
Authors: Ye Junhan
Published: August 2022

This article will focus on the relationship between Digital Humanities and Artificial Intelligence and will discuss the methodology of applying Artificial Intelligence in Digital Humanities; specifically, the article will target the applications in Dunhuang culture studying. The development of digital humanities facilitated by computers and the future research direction will be studied. The article aims to propose specific methods of applying Artificial Intelligence to Digital Humanities to facilitate the inheritance, development, and innovation of traditional culture. By sorting out the development process of digital humanities and combining it with the newest development direction of Artificial Intelligence forecasted by specialists in the area, the study will discuss the possible applications of the technologies in intangible cultural heritage studies. The methods include utilizing Smart Data to obtain structured and visual cultural heritage, implying Cross-media Intelligence to help reconstruct and propagate culture, and using Human-machine Association for the renovation and recreation of cultural heritage. Additionally, the specific methods of applying these methodologies to Dunhuang culture studying will be discussed, whose object is to realize natural language analysis, image style transfer using Smart Data, build digital museums using VR and AR, and restore murals in Mogao caves using Human-machine Association. The effects of these techniques on cultural heritage and its future development methodology will also be discussed.
Detection Technology of Social Robot: Based on the Interpretation of Botometer Model
Authors: Tian Jiawen , Huang Yiting , Zhang Dingyuan
Published: August 2022

In the era of Web 2.0, social media have been a significant place for democratic conversation about social or political issues. While in many major public events like the Russia-Ukraine war or U.S. Presidential election, enormous social bots were found on Twitter and Facebook, putting forward public opinion warfare. By creating the illusion of grassroots support for a certain opinion, this kind of artificial intelligence can be exploited to spread misinformation, change the public perception of political entities or even promote terrorist propaganda. As a result of that, exploiting detection tools has been a great concern since social bots were born. In this article, we focused on Botometer, a publicly available detection tool, to further explain the AI technologies used in identifying artificial accounts. By analyzing its database and combing the previous literature, we explained the model from the aspect of data augmentation, feature engineering, account characterization, and Ensemble of Specialized Classifier (ESC). Considering the consistent evolution of social bots, we propose several optimization suggestions and three other techniques or models to improve the accuracy of social bots detection.
Algorithmic Trading and Challenges on Retail Investors in Emerging Markets
Authors: Yan Siyuan , Ling Xiaoxu , Cao Tian , Hu Shengqi , Xiong Rong , Ye Hongbo , Zhang Ruihan
Published: August 2022

Mixed views on automated trading in the extant literature lead to ongoing debates on algorithmic trading (AT) and high-frequency trading (HFT). This study elaborates on the rising ethical issues and regulatory challenges of algorithmic trading and high-frequency trading in emerging markets. While developed capital markets are dominated by institutional investors, emerging markets consist of a large proportion of retail investors who may suffer from aggravated liquidity asymmetry and stock price turbulence due to HFT and AT. Furthermore, we review current regulations of HFT in the U.S. and European markets and provide a framework of regulatory enforcements on AT and HFT for investor protection in emerging markets. This study cautions policymakers in emerging markets that legal and regulatory monitoring of AT and HFT activities is especially necessary.
Managing Kidney Diseases in Bangladesh
Authors: Mostafi Mamun
Published: August 2022

Abstract not available
Bangladesh J Medicine 2022; 33: 233-234
Blokzincir, Veri Koruma ve Genel Veri Koruma Tüzüğü
Authors: TOPRAK Bilâl
Published: August 2022

Blokzincir her geçen gün kullanımı yaygınlaşan bir teknolojidir. Blokzincir ile kriptografi kullanılarak birbirine bağlanan blokların kayıt listesi tutulmaktadır. Blokzincirde veriler sıralanarak bloklara kaydedilir ve her blok bir zaman damgasına sahiptir. Bir blok dolduktan sonra yeni bir blok üretilir.
Dağıtık kayıt sistemlerinde veriler belirli bir yerde değil birden fazla yerde ve yine birden fazla kontrol mekanizmasıyla muhafaza edilerek güvenlik sağlanmaktadır. Böylelikle sistemde bulunan verinin sadece bir yerde tutulması halinde ortaya çıkabilecek olan bozulma, silinme ve saldırıya uğrama gibi problemler ortadan kalkmış olur. Blokzincir sistemi bir dağıtık kayıt sistemidir.
Herhangi bir veri parçası Blokzincir teknolojisi ile işlendiğinde, hash adı verilen benzersiz, 256 bitlik bir sayıya dönüştürülür. Aynı veri girildiği sürece her zaman aynı sonuç ortaya çıkar. Hash sistemi ters çevrilerek çalıştırılamaz, bu sayede sistemden çıkan sonuçtan sisteme giren verilere ulaşmak imkansızdır.
Genel Veri Koruma Tüzüğü madde 4/1’e göre; kişisel veri belirli veya belirlenebilir bir gerçek kişiye ait her türlü bilgi anlamına gelir. Bir Blokzincirin kullanım durumuna bağlı olarak bloklarda depolanan veriler, belirlenmiş veya belirlenebilir bir gerçek kişiye ait veriler olabilir.
Genel Veri Koruma Tüzüğü’ne göre veri sorumlusu kişisel verilerin işlenme amaç ve vasıtalarını tek başına ya da başkalarıyla birlikte belirleyen gerçek veya tüzel kişi, kamu makamı, kurumu ya da diğer bir kamu kuruluşu anlamına gelir. Blokzincir sisteminde veri sorumlusunun kim olabileceği, Blokzincirdeki bütün aktörlerin veri sorumlusu olarak kabul edilip edilemeyeceği, madencilerin hangi kategoriye sokulabileceği hususları değerlendirilmelidir. Ayrıca hash değerlerinin, açık anahtar ve özel anahtarların kişisel veri niteliği, değerlendirilmesi gereken bir başka konudur.
Genel Veri Koruma Tüzüğü’ne göre veri sahibinin veriye erişim, verinin düzeltilmesi ve verinin silinmesini talep etme hakkı bulunmaktadır. Blokzincir sisteminde veri sahibinin bu haklarını nasıl kullanabileceği belirsizdir. Genel Veri Koruma Tüzüğü madde 3’e göre, bu tüzük veri işlemenin Birlik sınırlarında gerçekleşip gerçekleşmediğine bakılmaksızın belirli şartlar dahilinde geniş bir çerçevede uygulama alanı bulur. Blokzincir sisteminin Genel Veri Koruma Tüzüğü’nün uygulama alanına girip girmediği incelenmelidir.
Evaluation of red snapper Lutjanus campechanus trophic dynamics with simultaneous stomach content and stable isotope analysis
Authors: Dillon KS , Slife C , Kohler B , Gibson D , Gray G , Franks JS
Published: August 2022

The importance of multiple prey taxa to red snapper Lutjanus campechanus diet was investigated using simultaneous stomach content analysis (SCA) and stable isotope analysis (SIA) over a 2 yr period in the north-central Gulf of Mexico (GOM) across 3 depth strata and 3 artificial structure types. Stable nitrogen isotope values were also used to estimate the trophic positions (TPs) of red snapper and prey items. SCA results showed that a variety of taxonomic prey groups were consumed, but the most frequent prey were stomatopods, portunid crabs and several families of fish. Some isotopic differences were found between red snapper size and age classes and across habitat types and depth strata for each sampling year; however, no consistent differences were found across the entire study period. Stable isotope mixing model results showed that diet varied annually, with sciaenid fishes being the greatest contributor in 2016 and portunid crabs in 2017, with the remaining proportions split across other taxa. Red snapper TP ranged from 3.4 to 4.8, while that of most prey groups was highly variable. The consistency in red snapper isotope values and the isotopic inconsistency of prey groups suggests that individual red snapper feed evenly across a taxonomically and isotopically diverse prey field. These results help develop a better understanding of reef ecology and food web structure in the northern GOM. Future investigations of red snapper diet that characterize reef habitats in terms of the available prey field and environmental conditions would improve our understanding of its trophic role in reef food webs.
Teknoloji, Şantiyelerde İş Sağlığı ve Güvenliğinin Kaderini Değiştirebilecek mi? Literatür ve Endüstriyel Uygulamalar Üzerinden Bir İnceleme
Authors: YILDIZ Serkan , YILMAZ Mustafa
Published: August 2022

Hayatımızın her alanına giren elektronik ve bilgisayar teknolojilerinden diğer tüm sektörlerde olduğu gibi inşaat sektöründe de İş Sağlığı ve Güvenliği (İSG) ’nin sağlanmasına yönelik yararlanma çabaları, son yıllarda başta gelişmiş ülkelerde olmak üzere tüm dünyada artış göstermektedir. İnşaat sektörü, ülkemizde iş kazası sonucu yaralanma ve ölümlerin en sık yaşandığı sektörlerin başında gelmektedir. Bu açıdan sektörde İSG’nin sağlanması için diğer her türlü imkânın yanında teknolojik yeniliklerin de devreye sokulması önemlidir. Bu noktadan hareketle gerçekleştirilen bu çalışmada, çeşitli veri tabanları üzerinden “teknoloji” “inşaat sektörü” ve “iş sağlığı ve güvenliği” anahtar kelimeleri kullanılarak kapsamlı bir tarama yapılmış ve inşaat sektörüne yönelik İSG teknolojileri belirlenmiştir. Belirlenen bu teknolojiler, kullanım alanlarına göre gruplandırılarak literatürdeki uygulamaların yanı sıra, sahada kullanılan ticari uygulamalar da incelenmiştir. Çalışma, inşaat sektöründe İSG’nin sağlanmasına yönelik olarak geniş bir yelpazede birçok teknolojik uygulama bulunduğunu ortaya koymuştur. Çalışmanın bazen çok küçük maliyetlerle ölüm ile hayatta kalma arasındaki farkı yaratan İSG teknolojilerinin Türk inşaat sektörü paydaşlarına tanıtılmasına ve bu sayede bu teknolojilerin kullanımının yaygınlaştırılmasına katkı sağlayacağı değerlendirilmektedir.
Relationship between Working Posture and Work Injuries in a Clothing Factory Workers in Edirne
Authors: AVCIBAŞI İlker Murat , DİNDAR İlknur
Published: August 2022

Straining movements, repetitive movements, vibration, staying in inappropriate posture for prolonged periods cause complaints such as pain in the in the musculoskeletal system, injuries, sprains, hernia, tears and soft tissue injuries. Complaints of excessive strain and frequent repetitions over time can suddenly arise, causing a work injury. The aim of this study is to determine the relationship between the working postures of textile factory workers and whether they affect work injuries or not. The postures of the workers during the job were analysed by videotaping them. Of all the participants (n=101), 75.2% were female, mean age was 33.4 ± 5.35 and 54.5% were high school graduate. Working experience mean was 8.53 ± 5.82 and the frequency of work injury was 18.8%. 57.8% of the workers in the textile industry exhibited a normal working position in category C1, 41.2% in C2, 0.5% in C3 and 0.1% in C4. However, it was observed that the educational level of workers who had experienced the WI was higher than the others and as the working experience increased the possibility of having injuries was statistically meaningful (p=0,014). In order to prevent work injuries in the textile industry, it is necessary to give in-service training about work safety to increase the awareness levels of females regardless of educational level.
THE BASIC LAWS OF TRADE
Authors: Rahman Abdurrahman Arum
Published: August 2022

According to the theory of comparative advantage of David Ricardo and Ohlin-Heckscher, countries with different resources and technology will benefit from trading, regardless of competitiveness. This is the core theory in international trade. However, in the real world, this theory does not always work. Some countries may gain from trading, some may not, and some may even lose. The total gain for all parties is also not optimal. We hypothesize another basic law that could fix this problem. This law is more basic than the comparative advantage. The theory of comparative advantage stands on this basic law. When the basic law is met, then comparative advantage theory works well, i.e. countries with different resources and technology will benefit from trading, regardless of competitiveness and cost. The total gain for all parties is optimal. We made trade simulations 2x2 and 5x20 to demonstrate the workability of this hypothesis.
APPLICATION OF DEA METHOD IN MEASURING OF MARKET EFFICIENCY OF BANKS IN BOSNIA AND HERZEGOVINA AND REFLECTION OF THE COVID-19
Authors: CİVİC Beriz
Published: August 2022

By using the DEA method, the paper measures market efficiency of the banks in Bosnia and Herzegovina in the period 2017-2020, in the context of challenges caused by the COVID-19. The aims of the research are: a) to measure market efficiency of the banks in Bosnia and Herzegovina and rank them using the DEA method (applying three models CCR-O, BCC-O, and Window-I-C), b) establish the effect of the COVID-19 pandemic on market efficiency of the observed banks, and c) established the link between the volume of digital banking services usage and market efficiency of the observed banks. The research results show that in 2020, when the COVID-19 appeared, CCR-O and BCC-O models revealed a decrease in market efficiency for 73.9% of the observed banks while Window-I-C model revealed lower market efficiency for all the observed banks. The regression analysis applied showed a significant link between the volume of digital banking services usage market efficiency of the observed banks. The regression model was established, pointing to a significant importance of independent variables for the prediction of the dependent variable.
A proteomics analysis of neointima formation on decellularized vascular grafts reveals regenerative alterations in protein signature running head: Proteomics analysis of neointima formation
Authors: Chen Chunyang , Lu Ting , Wu Zhongshi , Xie Xinlong , Liu Yalin , Huang Can , Liu Yuhong
Published: August 2022

Background: Neointima formation contributes to vascular grafts stenosis and thrombosis. It is a complex reaction that plays a significant role in the performance of vascular grafts. Despite its critical implications, little is known about the mechanisms underlying neointima formation. This study compares neointima proteome in different stages and plasma samples.

Methods: Heterogenous acellular native arteries were implanted as abdominal aortic interposition grafts in a rabbit model. Grafts were harvested at 0.5, 1, 4, 6, 7, 14, 21, and 28 days post-surgery for histological and proteomic analysis of the neointima.

Results: Histological examination showed a transformed morphological pattern and components, including serum proteins, inflammatory cells, and regenerative cells. Proteomics analysis of the neointima showed distinct characteristics after 14 days of implantation compared to early implantation. Early changes in the neointima samples were proteins involved in acute inflammation and thrombosis, followed by the accumulation of extracellular matrix (ECM) proteins. A total of 110 proteins were found to be differentially expressed in later samples of neointima compared to early controls. The enriched pathways were mainly protein digestion and adsorption, focal adhesion, PI3K-Akt signaling pathway, and ECM-receptor interaction in the late stage. All distributions of proteins in the neointima are different compared to plasma.

Conclusion: The biological processes of neointima formation at different stages identified with proteome found developmental characteristics of vascular structure on a decellularized small vascular graft, and significant differences were identified by proteomics in the neointima of early-stage and late-stage after implantation. In the acute unstable phase, the loose and uniform neointima was mainly composed of plasma proteins and inflammatory cells. However, in the relatively stable later stage, the most notable results were an up-regulation of ECM components. The present study demonstrates an interaction between biological matter and vascular graft, provides insights into biological process changes of neointima and facilitates the construction of a functional bioengineered small vascular graft for future clinical applications.
Modulating the surface potential of microspheres by phase transition in strontium doped barium titanate to restore the electric microenvironment for bone regeneration
Authors: Wang Peng , Zhou Xiaosong , Lv Caili , Wang Yu , Wang Zongliang , Wang Liqiang , Zhu Yongzhan , Guo Min , Zhang Peibiao
Published: August 2022

The endogenous electrical potential generated by native bone and periosteum plays a key role in maintaining bone mass and quality. Inspired by the electrical properties of bone, different negative surface potentials are built on microspheres to restore electric microenvironment for powerful bone regeneration, which was prepared by the combination of strontium-doped barium titanate (Sr-BTO) nanoparticles and poly (lactic-co-glycolic acid) (PLGA) with high electrostatic voltage field (HEV). The surface potential was modulated through regulating the phase composition of nanoparticles in microspheres by the doping amount of strontium ion (Sr2+). As a result, the 0.1Sr-BTO/PLGA group shows the lowest surface potential and its relative permittivity is closer to natural bone. As expected, the 0.1Sr-BTO/PLGA microspheres performed cytocompatibility, osteogenic activity in vitro and enhance bone regeneration in vivo. Furthermore, the potential mechanism of Sr-BTO/PLGA microspheres to promote osteogenic differentiation was further explored. The lower surface potential generated on Sr-BTO/PLGA microspheres regulates cell membrane potential and leads to an increase in the intracellular calcium ion (Ca2+) concentration, which could activate the Calcineurin (CaN)/Nuclear factor of activated T-cells (NFAT) signaling pathway to promote osteogenic differentiation. This study established an effective method to modulate the surface potential, which provides a prospective exploration for electrical stimulation therapy. The 0.1Sr-BTO/PLGA microsphere with lower surface potential and bone-matched dielectric constant is expected to have great potential in the field of bone regeneration.
Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca2+-modulated cAMP production
Authors: Wuchu Fulei , Ma Xiyang , Que Yanting , Chen Junjiang , Ruan Ye Chun
Published: August 2022

The regulatory interaction between two typical epithelial ion channels, cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial sodium channel (ENaC), for epithelial homeostasis has been noted, although the underlying mechanisms remain unclear. Here, we report that in a human endometrial epithelial cell line (ISK), shRNA-based stable knockdown of ENaC produced a biphasic effect: a low (∼23%) degree of ENaC knockdown resulted in significant increases in CFTR mRNA and protein levels, CFTR-mediated Cl−transport activity as well as intracellular cAMP concentration, while a higher degree (∼50%) of ENaC knockdown did not further increase but restored CFTR expression and cAMP levels. The basal intracellular Ca2+level of ISK cells was lowered by ENaC knockdown or inhibition in a degree-dependent manner. BAPTA-AM, an intracellular Ca2+chelator that lowers free Ca2+concentration, elevated cAMP level and CFTR mRNA expression at a low (5 µM) but not a high (50 µM) dose, mimicking the biphasic effect of ENaC knockdown. Moreover, KH-7, a selective inhibitor of soluble adenylyl cyclase (sAC), abolished the CFTR upregulation induced by low-degree ENaC knockdown or Ca2+chelation, suggesting the involvement of sAC-driven cAMP production in the positive regulation. A luciferase reporter to indicate CFTR transcription revealed that all tested degrees of ENaC knockdown/inhibition stimulated CFTR transcription in ISK cells, suggesting that the negative regulation on CFTR expression by the high-degree ENaC deficiency might occur at post-transcription stages. Additionally, similar biphasic effect of ENaC knockdown on CFTR expression was observed in a human bronchial epithelial cell line. Taken together, these results have revealed a previously unidentified biphasic regulatory role of ENaC in tuning CFTR expression involving Ca2+-modulated cAMP production, which may provide an efficient mechanism for dynamics and plasticity of the epithelial tissues in various physiological or pathological contexts.
Mitochondrial metabolism determines the functional status of human sperm and correlates with semen parameters
Authors: Irigoyen Pilar , Pintos-Polasky Paula , Rosa-Villagran Lucia , Skowronek Maria Fernanda , Cassina Adriana , Sapiro Rossana
Published: August 2022

The diagnosis of male infertility is based essentially on the patient’s medical history and a standard semen analysis. However, the latter rarely provides information on the causes of a possible infertility, emphasizing the need to extend the analysis of the sperm function. Mitochondrial function has been associated with sperm function and dysfunction, the latter primarily through the production of excessive amounts of reactive oxygen species (ROS). We hypothesized that analysis of sperm mitochondrial metabolism together with sperm ROS production could be an additional tool to improve routine semen analysis, after appropriate validations. To test our hypothesis, we performed several experiments using a non-routine method (high-resolution respirometry, HRR) to access mitochondrial function. First, we investigated whether mitochondrial function is related to human sperm motility and morphology. When mitochondrial metabolism was challenged, sperm motility decreased significantly. Additionally, morphological abnormalities in the sperm mid-piece and mitochondria were associated with global sperm defects evaluated by routine methods. Subsequently, sperm mitochondrial function was assessed by HRR. Respiratory control ratio (RCR) was determined and evaluated in the context of classical sperm analysis. In parallel, sperm hydrogen peroxide (H2O2) production and seminal plasma (SP) antioxidant capacity were measured. The percentage of sperm with progressive motility correlated positively with RCR, SP antioxidant capacity, and negatively with the concentration of extracellular H2O2 production ([H2O2]). The percentage of normal sperm morphology correlated positively with RCR and negatively with [H2O2]. Sperm morphology did not correlate with seminal plasma antioxidant capacity. Furthermore, Receiver Operating Characteristic curves were used for the first time to test the diagnostic ability of RCR, [H2O2], and SP antioxidant capacity as binary classifiers. An RCR cut off value of 3.2 was established with a sensitivity of 73% and a specificity of 61%, using reference values considered normal or abnormal in routine semen analysis. The cut off value for [H2O2] was 0.2 μM/106 sperm (sensitivity = 65%, specificity = 60%). There were no reference values for SP antioxidant capacity that distinguished between abnormal and normal sperm samples. We conclude that sperm mitochondrial function indices in combination with [H2O2] may be useful tools to complement the routine semen analysis.
The kingdom of the prolyl-isomerase Pin1: The structural and functional convergence and divergence of Pin1
Authors: Lee Yew Mun , Teoh Deryn En-Jie , Yeung Kay , Liou Yih-Cherng
Published: August 2022

More than 20 years since its discovery, our understanding of Pin1 function in various diseases continues to improve. Pin1 plays a crucial role in pathogenesis and has been implicated in metabolic disorders, cardiovascular diseases, inflammatory diseases, viral infection, cancer and neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s disease. In particular, the role of Pin1 in neurodegenerative diseases and cancer has been extensively studied. Our understanding of Pin1 in cancer also led to the development of cancer therapeutic drugs targeting Pin1, with some currently in clinical trial phases. However, identifying a Pin1-specific drug with good cancer therapeutic effect remains elusive, thus leading to the continued efforts in Pin1 research. The importance of Pin1 is highlighted by the presence of Pin1 orthologs across various species: from vertebrates to invertebrates and Kingdom Animalia to Plantae. Among these Pin1 orthologs, their sequence and structural similarity demonstrate the presence of conservation. Moreover, their similar functionality between species further highlights the conservancy of Pin1. As researchers continue to unlock the mysteries of Pin1 in various diseases, using different Pin1 models might shed light on how to better target Pin1 for disease therapeutics. This review aims to highlight the various Pin1 orthologs in numerous species and their divergent functional roles. We will examine their sequence and structural similarities and discuss their functional similarities and uniqueness to demonstrate the interconnectivity of Pin1 orthologs in multiple diseases.
Identification of a prognostic model using cuproptosis-related genes in uveal melanoma
Authors: Chen Yao , Chen Xiaozhen , Wang Xianggui
Published: August 2022

The most common intraocular malignancy in adults remains uveal melanoma (UVM), and those with metastatic disease have a poor outlook. Proliferation, angiogenesis, and metastasis of tumor cells can be triggered by cuproptosis, affecting the survival of cancer patients. Nonetheless, cuproptosis-related genes (CRGs) have not been identified in UVM. In this study, we analyzed 10 CRGs in 80 patients with UVM in the Cancer Genome Atlas (TCGA) database regarding the alterations of the genes including copy number variation and methylation. We further constructed a prognostic gene model using these CRGs and built the risk score formula. Univariate and multivariate Cox regression was applied to validate the risk score as an independent prognostic factor. The prognostic model was validated using 63 UVM samples from the GSE22138 cohort, an independent validation data set. Based on the risk scores for 80 patients with UVM from TCGA, we categorized the patients into high- and low-risk groups. Differentially expressed genes (DEGs) between groups were enriched in allograft rejection, hypoxia, glycolysis, TNFα signaling via NF-κB, and interferon-γ responses via Gene set enrichment analysis (GSEA). CD8 T cells and exhausted T cells were notably enriched in the high-risk group. In conclusion, the alteration of CRGs is related to patients with UVM, and the constructed CRG-related model may be helpful to predict the prognosis of such patients.