As proteínas de choque térmico e suas implicações como biomarcadores no diagnóstico de distúrbios fisiopatológicos: uma revisão
Authors: Gabriel Jane Eyre 
Published: July 2017

<!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:TargetScreenSize>800x600</o:TargetScreenSize> </o:OfficeDocumentSettings> </xml><![endif]--> <p class="MsoNoSpacing" style="text-align: justify;"><strong style="mso-bidi-font-weight: normal;">Introdução: </strong>Os mecanismos de adaptação ao estresse são caracterizados por uma resposta celular de emergência acionada especialmente em células e organismos expostos a diferentes agentes estressantes, promovendo a síntese acentuada de um grupo de proteínas altamente conservadas, denominadas proteínas de choque térmico (Hsps) ou proteínas de estresse. Inúmeros relatos têm discorrido sobre a crucial atuação desses polipeptídeos nos eventos de citoproteção em células e organismos estressados e nos mecanismos moleculares envolvidos no enovelamento correto de cadeias peptídicas lineares recém-sintetizadas. Na última década, um melhor entendimento das propriedades e das funções atribuídas às Hsps vem despertando um especial interesse em estabelecer uma estreita correlação entre variações significativas nos níveis plasmáticos de distintas Hsps e o diagnóstico precoce de múltiplas patologias. <strong style="mso-bidi-font-weight: normal;">Objetivo:</strong> Frente a esse cenário, a presente revisão de artigos científicos objetivou relatar o estado da arte acerca do papel crucial das proteínas de choque térmico como potenciais biomarcadores ao prognóstico e ao diagnóstico de graves distúrbios fisiopatológicos. <strong style="mso-bidi-font-weight: normal;">Metodologia:</strong> vinte e três artigos em idioma inglês, que tratavam especificamente da temática proposta, foram selecionados no período de fevereiro a agosto de 2014, utilizando informações contidas em distintos bancos de dados computadorizados, tais como: Pubmed/MEDLINE, Science Direct e Scielo. <strong style="mso-bidi-font-weight: normal;">Conclusões:</strong> Os artigos discutidos fornecem animadoras evidências experimentais ao efetivo emprego das proteínas de choque térmico como uma ferramenta adicional para maximizar procedimentos rotineiros na clínica médica, visando o prognóstico e diagnóstico de distintas patologias, além das moléculas alvos rotineiramente empregadas para tais fins.</p> <!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:HyphenationZone>21</w:HyphenationZone> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>PT-BR</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct 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