bluuebunny/crossref_metadata_2025 huggingface dataset:
The inhibition mechanism of epilepsy disease in a computational model
Authors: Hu Bing , Wang Zhizhi , Xu Minbo , Zhu Luyao , Wang Dingjiang
Published: February 2022

BACKGROUND: The mechanism of prevention and treatment of epilepsy is a hot issue in theoretical research. OBJECTIVE: In this paper, we studied the control mechanism of the generalized spike-and-wave discharges (GSWD) by different types of external electrical stimulation acting on the subthalamic nucleus (STN) in a computational model. METHODS: Firstly, we analyzed the pathological mechanism of seizures, which were induced by different parameters in the thalamocortical (TC) circuit. Then, a voltage V was exerted in the STN. At last, we used the sine wave and square wave current stimulation in the STN. RESULTS: We found that seizures can be inhibited by tuning stimulus intensity into suitable range, and the direction of adjustment depended on the size of the parameter. We observed that the seizure can also be inhibited by tuning different parameters in current. CONCLUSIONS: Different inhibition mechanisms can be explained in this model, which may provide theoretical evidences for selecting the optimal treatment scheme in the clinical.
Time taken for a primary tumor to metastasize to the brain and the overall survival of patients with brain metastasis: An analysis of outcomes and factors affecting survival
Authors: Hao Peiyu , Chen Limei , Ge Yuxi , You Yaqian , Yan Gen , Jin Zhe-Wu
Published: February 2022

BACKGROUND: Brain metastasis (BM) is one of the main causes of high morbidity and mortality in cancer patients. OBJECTIVE: To evaluate the factors that influenced the survival time of patients with primary cancer and survival time after BM. METHODS: Ninety patients with BM diagnosed by magnetic resonance imaging (MRI) were included in the study. We retrospectively analyzed the time to brain metastasis (TTB), overall survival time (OS1) and survival time after BM (OS2). The Kaplan-Meier method and Cox regression analysis were used for survival analyses. RESULTS: The median TTB was 12.0 (95% CI: 9.2–14.8 months), the median OS1 was 31.0 (95% CI: 25.8–35.2 months) and the median OS2 was 14.0 (95% CI: 10.9–17.1 months). Surgical excision of the primary tumor was an independent factor for a prolonged TTB (p< 0.000) and prolonged OS1 (p< 0.000). A single intracranial metastatic lesion was an independent protective factor for prolonged OS1 (p= 0.011) and prolonged OS2 (p= 0.050). TTB, OS1 and OS2 were analyzed with Gender (p< 0.000, < 0.000, and = 0.017, respectively). CONCLUSIONS: It suggests that TTB can be prolonged by primary tumor resection. Furthermore, women with a prolonged TTB and single intracranial metastasis are associated with high OS. These were helpful for the clinical treatment of BM patients before brain metastasis.
Novel dual-resistor-diode limiter circuit structures for high-voltage reliable ultrasound receiver systems
Authors: Choi Hojong
Published: February 2022

BACKGROUND: The limiters have been used to protect the ultrasound receivers because of the inherent characteristic of the transducers which are required to use the high voltage excitation to obtain the reasonable echo signal amplitudes. OBJECTIVE: Among the variety of the limiters, the performances of discharge voltage degradation from the limiters gradually deteriorate the whole ultrasound systems according to the applied voltages of the ultrasonic transducers. This could cause the ultrasound systems to be unreliable for the long-term operations, resulting in possibly breaking the receiver systems. METHODS: Designed limiters were evaluated with insertion loss, total harmonic distortion, and pulse-echo responses with the ultrasound transducer devices. RESULTS: Designed new dual-resistor-diode limiters exhibited greater and faster suppression of the pulse width (1.15 V and 6.1 μs) for high-voltage signals. CONCLUSIONS: Our proposed dual-resistor-diode limiter could be one of the potential candidates for reliable ultrasound receiver system.
Analysis of maximum joint moment during infant lifting-up motion
Authors: Kim Ji-Won , Eom Gwang-Moon , Kwon Yu-Ri
Published: February 2022

BACKGROUND: Infant care activities can induce musculoskeletal disease. However, little is known about the biomechanical joint load during lifting-up of an infant. OBJECTIVE: The aim of this study was to investigate normalized maximum moment during lifting-up of infant dummies weighing 4.6 kg, 7.6 kg, and 9.8 kg. METHODS: Six healthy young subjects participated in our study. All subjects performed lifting-up activities of dummies to shoulder height with their feet apart and natural postures in their comfortable speed. Three-dimensional reflective marker trajectories and ground reaction forces were used as input to calculate joint moments using a full body musculoskeletal model. Joint moments were normalized by each subject’s body mass. Friedman’s test was performed to compare mean differences of normalized joint moments for lifting up three dummy weights. RESULTS: Lumbar joint had the greatest normalized joint moment. Lumbar and hip extension moments were significantly increased with dummy weight (P< 0.05). In contrast, knee extension and ankle plantarflexion moment were not significantly affected by dummy weight (P> 0.05). CONCLUSIONS: These results indicate that the lumbar joint plays the most important role in infant lifting-up motion and that the load of lumbar and hip joint should be reduced when lifting a heavier infant. These results could contribute to the development of an effective lifting strategy and an assisting device for lifting an infant.
Integrating molecular interactions and gene expression to identify biomarkers to predict response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis patients1
Authors: He Min-Fan , Liang Yong , Huang Hai-Hui
Published: February 2022

BACKGROUND: Targeted therapy using anti-TNF (tumor necrosis factor) is the first option for patients with rheumatoid arthritis (RA). Anti-TNF therapy, however, does not lead to meaningful clinical improvement in many RA patients. To predict which patients will not benefit from anti-TNF therapy, clinical tests should be performed prior to treatment beginning. OBJECTIVE: Although various efforts have been made to identify biomarkers and pathways that may be helpful to predict the response to anti-TNF treatment, gaps remain in clinical use due to the low predictive power of the selected biomarkers. METHODS: In this paper, we used a network-based computational method to identify the select the predictive biomarkers to guide the treatment of RA patients. RESULTS: We select 69 genes from peripheral blood expression data from 46 subjects using a sparse network-based method. The result shows that the selected 69 genes might influence biological processes and molecular functions related to the treatment. CONCLUSIONS: Our approach advances the predictive power of anti-TNF therapy response and provides new genetic markers and pathways that may influence the treatment.
Detection of unrecognized spatial disorientation: A theoretical perspective
Authors: Hao Chenru , Cheng Li , Guo Lisha , Zhao Ruibin , Wu Yanru , Li Xiuyuan , Chi Ziqiang , Zhang Jingjing , Liu Xu , Ma Xiaohan , Wang Anqi , Dong Chunnan , Li Jing
Published: February 2022

BACKGROUND: Spatial disorientation (SD) is a problem that pilots often encounter during a flight. One reason for this problem is that among the three types of SD, there is no validated method to detect the Type I (unrecognized) SD. OBJECTIVE: In this pursuit, initially we reviewed the problems and the evaluation methods of associated with SD. Subsequently, we discussed the advantages and disadvantages of the subjective questionnaire evaluation method and the behavior evaluation method. METHODS: On the basis of these analyses, we proposed a method to detect the unrecognized SD that improved the assessment of SD to a significant extent. We developed a new direction to study the unrecognized SD based on the subjective report and the center of pressure (CoP). RESULTS: The proposed evaluation method can assist the pilots to understand the feelings and physical changes, when exposed to unrecognized SD. CONCLUSION: We hope that this evaluation method can provide a strong support in developing a countermeasure against the unrecognized SD and fundamentally solve the severe flight accidents arising due to them.
Development of composition and evaluation of equivalence of diacerein hard gelatin capsules
Authors: Салій О. О. , Лось О. В. , Баула О. П. , Турчина В. Ю.
Published: February 2022

Diacerein is a new generation of symptomatic slow-acting agent for the treatment of osteoarthritis, when taken orally, it exhibits moderate anti-inflammatory and analgesic activity, slows down the decay of cartilage tissue and relieves pain and swelling, but its physicochemical properties it is practically insoluble in water, due to which only 35‒56% the drug reaches systemic circulation. Therefore, the search for approaches to increase the dissolution rate of a practically insoluble API using the formulation, type of excipients, degree of solubility and kinetics of the substance release from hard gelatin capsules should provide guaranteed drug efficacy.

The aim of the work is to develop the composition of the drug in the form of hard gelatin capsules based on diacerein, to experimentally study the solubility of diacerein, and to evaluate the composition by studying the kinetics of dissolution of the drug.

Determination of the pH-dependent solubility of diacerein was carried out in the conditions: the volume of the dissolution medium is 250 ml; dissolution temperature 37.0 ± 0.5 ºС. The highest recommended single dose of 50 mg was investigated. The development of the composition of the drug Diacerein, capsules, 50 mg was carried out with the use of various types of excipients and their modifications to achieve the proper technological properties in terms of fluidity (flowability) and a short disintegration time of the capsules for the release of the active substance. Comparative studies of the kinetics of dissolution were carried out by the in vitro method, the test «Dissolution» was studied a «Paddle apparatus» with a rotation speed of 75 rpm, a dissolution medium with a pH value of 1.2, 4.5 and 6.8, in a volume of 900 ml at a temperature of 37 ± 0.5 ºС. The reference drug was used «Artrodarin®», capsules of 50 mg, manufactured by TRB PHARMA S. A.,vArgentina.

It was found that diacerein is practically insoluble in a buffer solution with a pH of 1.2, has a relatively low solubility in a buffer solution with a pH of 4.5, while the solubility of diacerein increases with an increase in the pH of the medium to 6.8. The optimal composition of capsules with diacerein using the wet granulation technology has been developed. The obtained data for bulk density and Carr's index indicate satisfactory flowability of the encapsulating mass. Comparative studies of the dissolution kinetics of the investigational medicinal product and the original drug «Artrodarin®», capsules of 50 mg were carried out. According to the calculations, all the obtained values of the similarity factor are in the range from 50 to 100 and indicate the similarity in buffer media with pH 1.2, 4.5 and 6.8. The developed composition of the preparation is equivalent in dissolution kinetics to the original medicine.
Timing pulsars: An exercise in statistical analysis and the scientific process
Authors: Walkup John , White Joseph , Key Roger
Published: February 2022

A lab activity for teaching students the fundamentals of statistical analysis by timing pulsar periods is described. The electromagnetic pulses of pulsars have been mapped to sound and uploaded on social media channels, allowing students to “listen” to the beat of the pulsar.  Because these beats are extraordinarily precise, they can serve as cyclic events of known time duration. The three-step process described in this article first requires that students select a timing method of low random error found by comparing standard deviations between two suggested methods. In the second step, students reduce systematic error by calibrating their optimal method using a pulsar of known time duration. Finally, students time an unknown pulsar (the mystery pulsar) using the optimal method chosen in Step 1 and calibrating out the bias found in Step 2. By expressing their results in terms of confidence intervals, they use a professional pulsar database to identify the mystery pulsar. Because students are not informed of the identity of the pulsar until after they turn in their lab reports, they are compelled to perform the measurements as carefully and objectively as possible. This activity provides a perfect vehicle for astronomy labs at the beginning of a semester — including online instruction — because it requires no prior instruction in astronomy and no equipment other than the stopwatch on a cell phone and internet connection. Furthermore, this activity offers an introduction to pulsars and such physics topics as magnetism and the conservation of angular momentum.
Az Európai Unió varázstalanítása
Authors: Bóka János
Published: February 2022

Az Európai Unió jövőjéről szóló érdemi vita nem lehetséges az Európai Unió varázstalanítása, azaz a politikai mítoszaihoz való tudatos és kritikus viszonyulás nélkül. Ennek érdekében azonosítanunk kell ezeket az európai integrációs mítoszokat, és fel kell tárnunk, miként torzítják az Európai Unió önképét. Elemeznünk kell, hogyan determinálják a mítoszok az integráció jövőjéről folyó vitát, és hogyan diszkvalifikálnak eleve bizonyos elképzeléseket és javaslatokat. Az írás ezzel a céllal vesz szemügyre néhányat az európai integráció mítoszai közül. Vizsgálja az európai békeprojektet mint az integráció eredetmítoszát, az európai demokráciát mint az integráció legitimációs mítoszát, az egyre szorosabb integrációt mint az integráció finalitásának mítoszát, illetve a költségvetési és politikai gesztusok mítoszát mint a nettó befizetők és kedvezményezettek közötti kasztrendszer alapját.
Egy figyelmen kívül hagyott lehetőség
Authors: Horváth Valéria
Published: February 2022

Az Egyesült Nemzetek Szervezetének menekültügyi intézménye (UNHCR) szerint 2017-benösszesen 30,6 millió ember kényszerült újonnan elhagyni lakóhelyét világszerte. Ezeknek az embereknek több mint fele – a közvélekedéssel ellentétben – nem fegyveres konfliktus miatt kényszerült elhagyni lakóhelyét, hanem természeti katasztrófa miatt. Ebből kifolyólag az ENSZ felfogása szerint az államok kötelesek humanitárius védelmet nyújtani minden embernek. A nemzetállamok álláspontja szerint azonban a lakóhelyüket tömeges mértékben elhagyni kényszerülők veszélyt jelentenek a befogadó ország gazdasági, társadalmi és politikai biztonságára. Gyakran azonban ezeket a biztonsági kockázatokat képtelenek egyedül kezelni. Mindeközben az EU számos, különböző olyan jogsegélyt nyújt a tagállamoknak, mint például a 2001-es Átmeneti Védelemről szóló Irányelv. Mivel az Európai Unió nem tudta a rendelkezésre álló eszközökkel megfelelően kezelni a 2015-ös migrációs válságot, az Európai Bizottság 2020-ban bejelentette az Új Migrációs és Menekültügyi Csomagot, amelyben többek között az Irányelv is reformra ítéltetett, és egy új, a migrációs és menekültügyi válsághelyzetek és vis maior események kezeléséről szóló rendelet váltaná fel azt. Jelen tanulmány célja, hogy górcső alá vegye az Irányelv és a Rendelet célját és alkalmazásának lehetőségeit a lakóhelyüket természeti katasztrófa miatt elhagyni kényszerülő személyekre vonatkozóan.
The Role of the Spanish Armed Forces in the Fight against the Covid-19 Pandemic
Authors: Hornyák Veronika
Published: February 2022

Similarly to other European countries, the Spanish Government decided to take extensive measures against the spread of the Covid-19 virus in the country with the announcement of special legal order, curfews and the deployment of the armed forces. The ‘Fuerzas Armadas Españ olas’, the FAS, have had an active role in the fight against the pandemic ever since executing a wide variety of tasks on a daily basis, including disinfecting critical infrastructure, and supporting the detection and the monitoring of infected citizens. Besides summarising the role of the Spanish Armed Forces in the fight against Covid-19 in the first year of the pandemic, the present paper explores other aspects of the deployment, such as civil–military relations and the attitude of the society towards military personnel.
Gondolatok négy Istvánt olvasva
Authors: Kiss Balázs , Burján Evelin
Published: February 2022

E recenzió célja Kukorelli István 2021-ben megjelent Három  István, három nemzeti ünnep, három példakép című könyvének megismertetése és ajánlása. A szerző három  példaképe, Szent István, Széchenyi István és Bibó István  gondolataival üzen az olvasónak.
EDUKASI UNTUK PASIEN DIABETES MELLITUS MELALUI PEMANFAATAN E-DISCHARGE PLANNING DI RS PKU MUHAMMADIYAH GAMPING
Authors: Sari Novita Kurnia , Syahruramdhani Syahruramdhani , Hernani Eny
Published: February 2022

Pasien diabetes mellitus yang tergabung dalam komunitas Persadia RS PKU Muhammadiyah Gamping tidak dapat melakukan pemantauan kesehatan dan edukasi secara rutin selama pandemic Covid-19. Hal ini terjadi karena pasien mengikuti anjuran untuk tidak keluar rumah dan mengurangi interaksi dengan orang lain. Pasien khawatir jika terpapar Covid-19 perbaikan penyakitnya akan lebih lama. Mengingat berdasarkan penelitian, pasien diabetes mellitus yang terpapar Covid-19 tingkat kematian, tingkat keparahan, dan kejadian sindrom pernafasan akut lebih tinggi dibandingkan dengan yang tidak mengalami diabetes mellitus.

 

Fokus kegiatan pengabdian masyarakat kali ini adalah pada pembuatan video edukasi yang diintegrasikan ke dalam aplikasi e-discharge planning yang telah dimiliki oleh RS PKU Muhammadiyah Gamping. Tahapan kegiatan yang telah dilaksanakan adalah identifikasi masalah, pembuatan draft panduan edukasi, pembuatan video, integrasi video kedalam sistem e-discharge planning, dan uji coba sistem.

 

Hasil kegiatan ini adalah telah dibuat 2 video edukasi tentang lima pilar diabetes melitus dan senam kaki diabetes mellitus. Kedua video ini telah diintegrasikan kedalam sistem e-discharge planning RS PKU Muhammadiyah Gamping dan secara resmi telah digunakan..
A abordagem da fitoterapia para a alfabetização científica em um projeto de horta nos anos finais do ensino fundamental
Authors: Loureiro Cristiane Tessinari Pupim Venturini , Lobino Maria das Graças Ferreira
Published: February 2022

O objetivo da pesquisa foi investigar a abordagem da fitoterapia no caminho para a alfabetização científica em um projeto de Horta/Laboratório vivo. A pesquisa explora e problematiza os conhecimentos adquiridos nas aulas teóricas e práticas de ciências no projeto em 2017, 2018 e 2019, relatando todo o percurso indicativo de abordagem da fitoterapia relacionada à alfabetização científica. Partiu-se da construção da horta e leitura histórica, com o objetivo de compreender de que maneira o tema é discutido ao longo dos anos. Trata-se de uma pesquisa qualitativa, caracterizada como pesquisa intervenção, apoiada em memórias e registros do diário de campo da professora/pesquisadora como dados principais e questionários com questões abertas, aplicadas aos sujeitos como instrumento de validação dos dados. Os resultados direcionam o olhar para o conhecimento por meio de ações que se desenvolvem nos três momentos pedagógicos. Apresentam-se os resultados colhidos em campo, tendo a horta como espaço de construção do conhecimento científico sobre a fitoterapia, bem como os desafios na continuidade e aprofundamento do projeto. Os resultados servem como balizadores para o aprofundamento das análises qualitativas sobre o conceito de alfabetização científica e fitoterapia, a partir de um projeto de horta como “Laboratório Vivo”.
ORGANIZATIONAL CULTURAL MODEL TO IMPROVE THE PERFORMANCE OF EMPLOYEES
Authors: Suwandi Yudi Wahyudin
Published: February 2022

This research aims to find out, review, and analyze employees' cultural models and performance at the Rural Bank. In carrying out its mission, a rural bank, especially in the Cimahi city area, is fully supported by OJK in carrying out its duties as a fund-raiser and fund-raiser. Tight banking competition that leads to financial technology in conducting its transactions, so that it is no less competitive, especially the number of customers who move to other banks, because of facilities and systems that do not support, so far that became a segment of rural bank customers in West Java, especially Cimahi city oriented to rural circles. In developing the vision and mission of rural banks themselves, the rural bank should be able to penetrate among customers to a higher level by not neglecting the mission of rural banks to help the community or the populist economy that commercial banks have not touched. The method in research uses a quantitative method with descriptive and verificative analysis, descriptive research aims to know the condition of the cultural organization and performance of rural bank employees, and verificative research to test how much influence the culture of the organization partially and simultaneously on the employee performance on rural bank Cimahi.
Распространенность травматических поражений слизистой оболочки рта у пациентов, находящихся на ортодонтическом лечении с Covid-19 в анамнезе
Authors: Иванова О.П. , Карпук И.Ю. , Денисова Ю.Л.
Published: February 2022

Распространенность поражений слизистой оболочки рта у ортодонтических пациентов, перенесших коронавирусную инфекцию, ранее не была исследована. Цель исследования. Изучение распространенность поражений слизистой оболочки рта у пациентов, находящихся на ортодонтическом лечении с COVID-19 в анамнезе. Объекты и методы исследования.Работа основана на проспективном и ретроспективном исследовании результатов обследования 74 пациентов, находящихся на ортодонтическом лечении. Было проведено обследование пациентов, находящихся на ортодонтическом лечении с использованием несъемной ортодонтической аппаратуры на кафедре стоматологии детского возраста и ортодонтии с курсом ФПК и ПК УО «Витебского государственного ордена Дружбы народов медицинского университета» и филиала №1 УЗ «Витебского областного клинического стоматологического центра» в период с января 2020 г. по сентябрь 2021 г. При обследовании пациентов проводился сбор жалоб, анамнеза, осмотр полости рта с занесением данных в карту обследования пациента. В данном исследовании определяли распространенность травматических поражений слизистой оболочки рта (СОР) пациентов, скорость саливации, Ph ротовой жидкости и вязкость ротовой жидкости. Результаты исследования и их обсуждение. Пациенты, перенесшие коронавирусную инфекцию (COVID-19), подвержены более высокому риску травматизации СОР, в том числе на фоне угнетенной функции слюнных желез. У пациентов с коронавирусной инфекцией в анамнезе преобладали сочетанные травматические поражения и поражения слизистой оболочки щек, которые проявлялись в форме катарального воспаления (участки гиперемии и отека), эрозирования и образования язв на слизистой оболочке рта. Распространенность сочетанных поражений СОР достоверно выше (p < 0,05) у пациентов, перенесших коронавирусную инфекцию в легкой и средне-тяжелой формах. Заключение. Результаты исследования свидетельствуют о более высокой распространенности травматических поражений СОР у ортодонтических пациентов, перенесших COVID-19.
Implementation of Village Governance Based on the Principles of Good Governance of Public Service in Indonesia
Authors: Junaedi
Published: February 2022

Implementation of Village Government Governance based on Good Governance Principles in Indonesia. A village government is a government carried out by village officials who head a village. In realizing good and responsible governance, it is inseparable from the community's participation to support the implementation of the desired government. In the community, there is enormous potential and resources, if used properly, will make a real contribution to the progress of the community and the village. Various experiences show that governance and development without involving public participation will face serious problems. Therefore, government factors must realize that the community should be involved in every stage of the process of government and development programs. The community is a stakeholder that should not be ignored because they have a strategic role and potential for government and village development continuity.
Notes to lichen-forming and lichenicolous fungi in Ukraine II
Authors: DARMOSTUK VALERII VIKTOROVYCH , KHODOSOVTSEV ALEXANDER YEVGENOVYCH , GROMAKOVA ALLA BORYSIVNA , SIRA OLHA YEVGENIVNA , DAVYDOV DENYS ANATOLIYOVYCH , GAVRYLENKO LUBOV MYKOLAIVNA , KHODOSOVTSEVA YULIA ANATOLIIVNA
Published: February 2022

In this contribution, new data concerning lichen-forming and lichenicolous fungi in Ukraine are presented. It includes new records, exclusions, and confirmations to the Ukrainian administrative regions of taxa in the genera of Absconditella, Alyxoria, Arthonia, Athelia, Briancoppinsia, Buellia, Buelliella, Caloplaca, Candelariella, Chaenotheca, Circinaria, Clypeococcum, Didymocyrtis, Diplotomma, Hypocenomyce, Lawalreea, Lecania, Lecidea, Lichenochora, Lichenoconium, Lichenostigma, Micarea, Monodictys, Mycomicrothelia, Muellerella, Naevia, Pachyphiale, Parmeliopsis, Pertusaria, Phaeophyscia, Phoma, Physcia, Physconia, Piccolia, Placynthiella, Polycoccum, Polyozosia, Porpidia, Pronectria, Protoparmeliopsis, Pseudoschismatomma, Punctelia, Ramalina, Rinodina, Sarcopyrenia, Sclerophora, Sphaerellothecium, Staurothele, Strangospora, Stigmidium, Taeniolella, Tephromela, Thelocarpon, Tuckermannopsis, Verrucaria, Xanthoparmelia, Xanthoria, Zeroviella. Among them 24 species of lichen-forming and lichenicolous fungi are new to the Kharkiv region, 13 species new to the Rivne region, 9 species new to the Mykolaiv region, 6 species new to the Kherson region, 3 species new to the Zaporizhzhia region, 3 species new to the Ivano-Frankivsk region, 3 species new to the Ternopil region, 2 species new to the Dnipropetrovsk and Zakarpattia, Chernivtsi and Volyn regions, one species new to the Chernihiv, Khmelnytskyi, Kyiv, Poltava, Sumy regions as well as 5 species new to Autonomous Republic of Crimea.
Juventude, trabalho e sonhos: perspectivas de uma escola pública na pandemia
Authors: Dos Santos Andréia , Barbosa Emilly Vitória Ribeiro , Pereira Lavínia Bárbara do Couto
Published: February 2022

Este artigo é uma análise exploratória que visou entender a relação dos jovens estudantes diante do Regime Especial de Atividades Não Presenciais (REANP), em uma escola da rede pública de Minas Gerais. Tal modalidade de estudo vem sendo proposta em função da pandemia de Covid-19 causada pelo novo coronavírus (SARS-CoV-2). Buscou-se compreender as dificuldades de aprendizagem, a relação entre escola e trabalho, bem como as perspectivas dos alunos para os projetos de vida após a conclusão do Ensino Médio. Para isso, realizou-se uma pesquisa por meio de questionário semiestruturado, disponibilizado via Google Forms e distribuído via Whatsapp para os alunos do Ensino Médio inseridos em uma escola pública de Contagem. Parte das discussões teóricas do trabalho se constituíram por meio das leituras propostas dentro do Programa Residência Pedagógica de Sociologia da Pontifícia Universidade Católica de Minas Gerais, que permitiram uma reflexão sobre as desigualdades da educação pública brasileira.
Contribuindo para o florescimento do Departamento de Sociologia do Colégio Pedro II: entrevista com Felipe Bon
Authors: Leitão Ana Beatriz , Sampaio Beatriz , Oliva Carlos Eduardo , Cordeiro Jr. José Amaral , Mosca Jr. Roberto , Dos Santos Sophia
Published: February 2022

Entrevista realizada no âmbito do projeto de iniciação científica Ciências Sociais e Memória: registro de ações para Educação em Direitos Humanos, realizado junto ao Grupo de Estudos em Ciências Sociais e Memória (GECISME) vinculado ao LAEDH - Laboratório de Educação em Direitos Humanos do Colégio Pedro II - e apoiado pela Pró-Reitoria de Pós-Graduação, Pesquisa, Extensão e Cultura (PROPGPEC) do Colégio Pedro II, com o professor Luiz Felipe Guimarães Bon, professor do Departamento de Sociologia do Colégio Pedro II há quase três décadas, último chefe de departamento e primeiro coordenador-geral (nova nomenclatura do antigo cargo de chefe de departamento, alterada em seu mandato) do Departamento de Sociologia do Colégio Pedro II, que nesta entrevista conta sobre sua origem familiar, sua vida escolar, sua entrada no mundo do trabalho como entregador de jornais e como bancário, sua formação em Ciências Sociais e sua trajetória no Departamento de Sociologia do Colégio Pedro II, ao qual se dedicou com especial ênfase durante seus mandatos de chefia e coordenação-geral, se voltando para um florescimento do departamento, com a criação de laboratórios de humanidades, da Especialização em Ciências Sociais e Educação Básica e de uma licenciatura em Ciências Sociais, entre outras iniciativas do período.
Migración de Finos en el Reservorio Hollín: Diagnóstico, Evaluación y Prácticas de Estimulación desde el Laboratorio hasta la Implementación en Campo
Authors: Ruilova Mayra , Izurieta Álvaro
Published: February 2022

El presente estudio muestra las diferentes pruebas de laboratorio utilizadas para reconocer los mecanismos de daño de formación y enlazar el comportamiento de producción asociado con la arenisca Hollín de la Cuenca Oriente. Se sugieren distintos tratamientos para mejorar la productividad y expandir la vida productiva del pozo. El análisis comienza con un diagnóstico con base en los históricos de producción del campo de estudio, definiendo la migración de finos como mecanismo de daño principal, esta hipótesis es luego verificada mediante Difracción de rayos X que nos mostraron la presencia de caolinita e ilita en los núcleos estudiados. Una vez identificado el mecanismo de daño del reservorio Hollín, se procedió a recomendar fluidos amigables con la formación, así como tratamientos de estimulación matricial con base en las pruebas de retorno de permeabilidad para fluidos de control, sistemas ácidos, estabilización de finos, y modificadores de permeabilidad relativa. Además, se propone fractura hidráulica en combinación con los tratamientos antes descritos como alternativa para mejorar y extender la vida productiva de los pozos.
Overcoming the problem of cultural untranslatability in Burnett’s the secret garden from English into Indonesian
Authors: Ma'shumah Nadia Khumairo , Sajarwa Sajarwa
Published: February 2022

This study aimed at investigating the untranslatable cultural terms found in the novel from English into Indonesian since not all cultural terms in Source Text can be fully transferred into Target Text as well as the translator’s decision to overcome the problem of untranslatability since English and Indonesian have very different cultural concepts. This study was a data-driven study by using The Secret Garden’s novel written by Burnett (1911/2019) as the Source Text (ST) and its Indonesian translation by Kusumawardani (2020) (under the same title) as the Target Text (TT). The data were analyzed by using descriptive-mix-comparative methods that combined the theory of Newmark’s (1988) cultural terms categorization and Newmark’s (1988) translation procedures. As a result, to overcome the problem of cultural untranslatability, the translator frequently employs transference, naturalization, and notes procedures. From in-depth analysis, transference by retaining the SL’s cultures in the TL is used to avoid mistranslation because the lacks a formally corresponding feature. Naturalization is used by adapting the SL cultural-specific words to the TL's normal pronunciation and morphology because there are designation similarities in both the SL and the TL. Meanwhile, notes in the form of in-text annotations and footnotes were used to strengthen the translator's role by highlighting her in the translation results. Nevertheless, notes are commonly used in conjunction with naturalization to reduce strangeness, as leaving too many untranslatable cultural references weakens the translation result.
Development of Recommendations for Catering Industry Illumination Systems
Authors: Endiyarova Natalya V. , Tolstoba Nadezhda D.
Published: February 2022

The article describes development of the set of recommendations concerning design and modernisation of illumination systems for catering industry. Relevant publications were studied, a number of parameters of illumination systems and colour layouts of catering outlets were reviewed, three scenarios of restaurant illumination were modelled, a questionnaire was developed and potential restaurant visitors (of different gender and age) were surveyed, and the summarised list (set) of recommendations to be used in design of catering outlets was formed.
Pakistan’da Hadis Tartışmaları Yazar: Inam Ul Haq, (Ankara: Türkiye Diyanet Vakfı Yayınları, 2020, 428 sayfa.)
Authors: AKPINAR Ömer Faruk
Published: February 2022

Bu yazı, "Pakistan’da Hadis Tartışmaları, İnam ul Haq. Ankara: Türkiye Diyanet Vakfı Yayınları, 2020, 428s." künyeli kitabın değerlendirmesinden ibarettir.
MÜŞKİLÜ’L-HADİS VE HABERÎ SIFATLARIN TE’VİLİ NOKTASINDA EHL-İ HADİSE BİR REDDİYE
Authors: AYDIN Osman
Published: February 2022

Bu araştırmada Eş‘ârî mütekellim İbn Fûrek’in (ö. 406/1015), haberî sıfatlara dair rivayetleri te’vîl noktasında İbn Huzeyme’ye (ö. 311/924) yönelik tenkitleri ele alınacaktır. İbn Fûrek böylesi haberleri te’lîfe gayret gösterdiği Müşkilü’l-âsâr isimli eserinde, İbn Huzeyme için hususî bir bölüm açmış ve burada eleştirilerine yer vermiştir. Çalışmanın amacı, farklı ilmî duruşa sahip kişiler ya da kesimler arasında gerçekleşen “reddiye”lerdeki eleştiri üslûbuna ve bunun niteliğine tesir eden etkenleri doğru tespit etmektir. Bu bağlamda yöntemsel açıdan; mezkûr iki isimden İbn Fûrek’in te’vîl metodunu benimsemesi, İbn Huzeyme’nin ise tevakkuf yönteminin temsilcisi bir Ehl-i Hadis alimi olması ve her ikisinin de haberî sıfatları izâh noktasında ve Müşkilü’l-hadis sahasında husûsi eserlerinin bulunması sebebiyle tümevarım yöntemine başvurulmuştur. Kezâ İbn Fûrek’in eleştirilerinin nev‘ini anlamlandırabilme adına karşılaştırma usûlüne de sıklıkla yer verilmiştir. Kapsam ve sınırlılıklar noktasında İbn Fûrek ve İbn Huzeyme’nin eserleri ile bir tahdîde gidilmesine karşın; ilmî, fikrî ve mezhebî anlamda onların durdukları yerleri belirleyebilmek açısından meseleye dair genel literatür de mercek altında tutulmuştur. Makalede, böylesi tenkitlerin altında en az ilmî gayeler kadar, mezhebî aidiyet ve taassub gibi faktörlerin de bulunabileceğinin göz ardı edilmemesi gerektiği varsayımından yola çıkılmıştır. Sonuç itibarıyla; İbn Fûrek özelinde kendisinin eleştirilerinin haklı yanları saklı tutulmakla birlikte, kimi zaman görüşünü destekleyebilmek adına bazı rivayetleri ve delilleri görmezden gelebildiği, gerek rivayet gerekse usûle yönelik eleştirdiği hususları bizzat kendisinin tatbik edebildiği, muârızını ilmî anlamda itibarsızlaştırma üzerinden ilzâma çalışabildiği gibi sonuçlara ulaşılmıştır. Buradan hareketle reddiye mantığı ile kaleme alınan çalışmalarda benzer problematik sahaların muhtemel olduğu söylenmelidir.
A Successful Case of an Acquired Methemoglobinemia Treated with Methylene Blue
Authors: D Almeida , M Remelhe , H Castro , H Machado
Published: February 2022

Methylene blue has been advocated for multiple indications, but data reporting its use on intoxication is rare. Acquired methemoglobinemia can be caused by a wide variety of chemicals and toxins and on severe cases, with high methemoglobin levels (>20%), methylene blue is the first line treatment. We describe a case report of a 45-year-old man with acute methemoglobinemia due to involuntary exposure to n-propyl nitrate. The patient came into the emergency department conscious, with profound peripheral and central cyanosis and oxygen saturation of 88% on air, with no response to oxygen supplementation. Arterial blood gas showed methemoglobin of 22.9%. Methylene blue was administered intravenously and symptoms improved dramatically, with control arterial blood gas with 2.6% of methemoglobin. Despite the rarity of occurrence of methemoglobinemia in occupational set, and since methylene blue is highly effective, a high degree of suspicious and good training aiming for prompt diagnosis is crucial in treating this emergency situation.
Laterality of Colorectal Cancer (CRC) in Oman
Authors: Al Bahrani Bassim Jaffar , Mehdi Itrat , Monem Essam Abdul , Farsi AbdulAziz Majid Al , Lawati Najla Al , Nada Ayman Mohammed
Published: February 2022

Introduction: Colorectal cancer (CRC) is the first most predominant malignancy in men, a bit less 3rd commonest in women. The prevalence rate is higher in developed than in developing economies, though the pattern is gradually changing. In Oman, CRC prevalence rate has shown a significant escalating pattern in the recent past. From 1996 to 2012, CRC incidence in Oman has increased by 282% in females and 386% in males. There is emerging data that right and left sided lesions are different in terms of aetiology, pathogenesis, biologic behaviour, genetic makeup, response to treatment and outcome. This study has looked at this issue in the Omani population of CRC. Methods: Eligible CRC patients treated at the Royal Hospital were identified from electronic medical record (Al-SHIFA 3) and Oman cancer registry data base (Ministry of Health) from 1998-2013. The BMI (body mass index), age, gender, stage, tumour location, K-Ras status, and Diabetes mellitus (DM) were explored. The RAS mutation status test (mutant type MT or wild type WT) was carried out in Lab21. Log regression was conducted to estimate the association between food intake, BMI, presence of metabolic syndrome, and level of physical activity with both cancers. Data was analysed using the SPSS. Results: Total number of patients treated at Royal Hospital were 492, 193 females (44%) and 214 males (56%). About 71.9% of patients were less than 60 years of age. The obese and overweight patients were 201 (57.3%). The rectum was found to be the predominant site of the tumor. The left sided tumors were significantly higher, 4 out of every 5 tumors (80.3% Vs 16.4%). The patients with right sided CRC were slightly younger, had a higher BMI, and more likely to be diabetic. The tumors of the left colon are more K-ras wild while those of the right colon are more K-ras mutant. Conclusions and Discussion: The right sided tumors as per our study are younger; with significant obesity, diabetes, and K-Ras mutant, and this correlates with high meat and protein consumption in the Omani population. The sidedness or laterality of CRC needs further study in Oman. There is emerging data that right and left-sided lesions are different in terms of etiology, pathogenesis, biologic behaviour, genetic makeup, response to treatment and outcome.
Mifepristone May Be the Best Single Pharmaceutical Agent for Treatment of a Variety of Advanced Cancers
Authors: Check Jerome H. , Check Diane
Published: February 2022

Rationale: To provide evidence to support the provocative statement that the progesterone receptor modulator (antagonist) mifepristone may be the best single anticancer drug to use for advanced metastatic cancer. Objective: A summary of cancer cell line studies, controlled treatment trials of several types of spontaneous murine cancers, and anecdotal human case reports that support the premise of this review, is provided. The concept suggests that the mechanism of action involves the suppression of an immunosuppressive protein called the progesterone induced blocking factor (PIBF) that requires stimulation of a membrane progesterone receptor for its production. Findings: Cell line studies show that mifepristone can down-regulate PIBF production by many different leukemia cell lines and inhibit proliferation of cancer cell lines, e.g., ovarian cancer and glioblastoma multiform stage IV. Controlled murine studies found improved longevity and quality of life as monitored by body conditioning scores following oral gavage of mifepristone including leukemia, lung, testicular, and prostate cancer. Most importantly, mifepristone anecdotally has been found to provide extension of life and improved quality of life in patients with a large majority of advanced cancers that were no longer responding to any available anticancer drug options. These cancers include colon, kidney, small cell and non- mall cell lung, pancreatic, thymic epithelial cell, transitional cell of the renal pelvis, grade IV glioblastoma multiform, fibrous osteogenic sarcoma, and leiomyosarcoma cancers. Of note, the majority of the cancers treated are not known to be associated with the presence of classical nuclear progesterone receptor. Conclusions: Related to additional benefits of easy oral administration, low cost, low risk of short-term side effects, or immediate, severe, or delayed severe complications, and its efficacy despite starting it, in general, in late stages of advanced metastatic disease in patients previously treated with standard or experimental drugs, and its beneficial effects in a large variety of cancers, mifepristone may be the best single agent anticancer drug for the treatment of advanced cancers.
Perfil de pacientes internados por Acidente Vascular Cerebral em uma unidade de urgência e emergência em um hospital escola do Oeste do Paraná e a atuação do profissional fisioterapeuta nestes casos
Authors: Branco Carla Lautenschleger , Genske Juliana Hering , Bavaresco Alana Caroline , Almeida Caio Fernandes de
Published: February 2022

Objetivo: Fazer o levantamento dos casos atendidos pelo serviço de fisioterapia e quais foram as condutas utilizadas por esses profissionais e traçar o perfil de pacientes admitidos por Acidente Vascular Cerebral na unidade de emergência no ano de 2020. Metodologia: Estudo observacional, retrospectivo, transversal, de caráter quantitativo, analisando pacientes que deram entrada na sala de emergência do Hospital Universitário do Oeste do Paraná (HUOP), no período de um ano. A coleta de dados foi realizada utilizando-se uma ficha previamente elaborada contendo as variáveis do estudo; a análise foi realizada por meio de estatística descritiva simples. Resultados: Foram encontrados 1.020 prontuários, onde 17 prontuários foram excluídos. Dos prontuários analisados, 186 foram por AVC, com maior prevalência no AVC isquêmico (77,42%), sexo masculino (51,08%) e naqueles com idade >60 anos (68,28%). Ocorreram 64 óbitos, sendo 48 com AVC isquêmico e 16 com AVC hemorrágico. 84,95% dos pacientes receberam atendimento fisioterapêutico. Conclusão: Conclui-se que o atual estudo vai de acordo com demais pesquisas, com maior prevalência de casos de AVC isquêmico, além de maiores taxas de diagnósticos no sexo masculino e em idades acima de 60 anos. Quanto ao desfecho, a maioria dos pacientes receberam alta hospitalar, ocorrendo apenas 64 óbitos. Em relação a fisioterapia, foram principalmente empregadas condutas motoras e respiratórias associadas, e apenas 15,05% não receberam nenhum tipo de atendimento fisioterapêutico.
Qualidade de frutos de melancia sob diferentes dosagens de adubação nitrogenada
Authors: Anjos Rodrigo Afonso dos , Santos Mateus Aparecido Rodrigues , Oliveira Júnior Manoel Xavier de , Bezerra Neto Francisco Valdevino , Amaral Alisson Macendo , Santos Maria Ângela Cruz Macêdo dos
Published: February 2022

Este trabalho teve como intuito analisar o efeito da aplicação de nitrogênio sobre os componentes de qualidade de frutos da melancia “granada”. Para isso, foi realizado um experimento na fazenda Extrema, situada no município de Arinos, estado de Minas Gerais, no período de setembro a dezembro de 2018. O delineamento experimental adotado foi o de blocos inteiramente casualizados, com cinco tratamentos e quatro repetições. Os tratamentos constituíram-se de cinco níveis de adubação nitrogenada: 0, 40, 80, 160 e 320 kg ha-1 de N. As análises dos frutos foram feitas no laboratório de Química do Instituto Federal de Educação, Ciência e Tecnologia Norte de Minas Gerais – Campus Arinos. Foram realizados testes físico-químicos para a determinação de sólidos solúveis totais (°Brix), pH, acidez titulável (AT) e espessura de casca. A adubação nitrogenada apresentou efeito significativo sobre as variáveis analisadas, exceto no pH dos frutos. O maior teor de sólidos solúveis (8,27 °Brix) foi obtido ao nível de 171,7 kg ha-1 de N. Para AT e espessura de casca, foram ajustados modelos lineares significativos (p<0,01).
Recurrent Episodes of Angioedema as Presenting Feature of JAK2-Positive Myeloproliferative Disorder Consistent with Polycythaemia Vera
Authors: Al-Azrai Laith , Mustafa Ala’a Abdullah Bani , al-Wahadneh Adi Yousef
Published: February 2022

Polycythaemia vera (PV) is one of the chronic myeloproliferative neoplasms, which are collectively characterised by clonal proliferation of myeloid cells with variable morphologic maturity and haematopoietic efficiency. PV is distinguished clinically from other myeloproliferative neoplasms by the presence of an elevated red blood cell mass because of uncontrolled red blood cell production. This is accompanied by increased white blood cells and platelet production, which is because of abnormal clone of haematopoietic stem cells with increased sensitivity to the different growth factors for maturation. PV can present with variable symptoms because of impaired oxygen delivery caused by slugging of blood, such as headaches, dizziness, vertigo, tinnitus, visual disturbances, and angina pectoris.

Some patients present with bleeding complications (1%); another 1% of patients present with thrombotic complications. It is uncommon for patients with myeloproliferative disorders to present with features of angioedema. There are many reported cases in the literature that describe the relationship between the occurrence of angioedema and lymphoproliferative diseases; however, there are no reported cases describing instances of myeloproliferative neoplasm with angioedema.

In this article, the authors have studied a case of a 53-year-old male who presented with recurrent episodes of features that are suggestive of angioedema. He was diagnosed with JAK2-positive myeloproliferative disorder consistent with PV; this is the first reported case in Jordan.