bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective Inhibitor Design Against Thymidylate Synthase of Mycobacterium tuberculosis using Alchemical Simulations
Authors: Sengupta Pallav , SATPATI PRIYADARSHI
Published: August 2024

Thymidylate synthase is an essential enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidylate synthase from Mycobacterium tuberculosis (MtbThyX) recognizes the deprotonated substrate dUMP(d) (ionized at N3, charge = -3) involving cationic side-chain of Arg199, whereas the human analog (hThyA) select the natural substrate dUMP (charge = -2) by involving polar side-chain of Asn226 in the binding pocket. Distinctly different protonation states of the substrate and the catalytic pocket architecture make MtbThyX an attractive drug target for combating Mycobacterium tuberculosis. Fluorodeoxyuridylate (FdUMP) is a known inhibitor of thymidylate synthase, which is severely limited by poor selectivity (more potent against hThyA relative to MtbThyX). Using FdUMP as a template, we designed three drug-like ligands, L1, L2, and L3, by (1) removing the proton from the Watson-Crick edge and (2) substituting the ketone/hydroxyl group by fluorine and or carboxylic moiety. The absence of a proton on the N3 atom of the ligand is intended to ensure selectivity by favoring MtbThyX binding (skipping the N3 ionization requirement) but penalizing hThyA binding (disrupting the interaction with Asn226). Ionization of the carboxyl group in the ligands was expected to increase the affinity in the cationic binding pocket of MtbThyX. Alchemical simulations confirmed that the designed ligands are strongly favored and disfavored relative to the substrate (dUMP) by MtbThyX and hThyA, respectively. In contrast to hThyA, the catalytic pocket of MtbThyX proved to be relatively dry and stabilized the relatively compact conformation of the ligand (which had a noticeable effect on the sugar puckering). Favorable protein-ligand electrostatic interaction in the dry MtbThyX pocket strongly favored ligand binding. In contrast, the interaction between the Watson-Crick edge of ligands and hThyA was compromised, resulting in water exposure. Ligand L2 is particularly advantageous for its highest affinity for MtbThyX and weak affinity for hThyA. The L2:MtbThyX complex is stabilized by a new salt-bridge interaction (COO- of L2…Arg107 of protein) and a bridging water molecule (between COO- of L2 and E92 of protein) in the binding pocket. Moreover, our estimated pKa of -8 unit of N3 (dUMP) in the MtbThyX catalytic pocket indicated the strong acidic nature of the uracil, corroborating previous experimental and computational claims. These findings provide insights into the protein-ligand binding affinity in atomic details and a rational approach for inhibitor design against MtbThyX.
DFT Study of the Arbuzov Reaction Mechanism between Ethyl Halogenides and Trimethoxyphosphine
Authors: Filippova Anastasia , Syzgantseva Maria , Galitsin Alexander , Syzgantseva Olga
Published: August 2024

The mechanism of the reaction between ethyl chloride or ethyl bromide with trimethoxyphosphine in a non-polar (ε = 1) and polar medium (methanol, ε = 32.7) was studied within the density functional theory (DFT) using MOLPRO program. It was shown that the reaction occurs in 2 stages: first, a nucleophilic attack of the carbon atom by phosphorus occurs, followed by the interaction of methyl of one of the methoxy groups with the halide. The limiting stage in all cases is the second stage of the reaction, the barrier of which is approximately 1.5 times higher than the barrier of the first. The reaction barriers are lower for the reaction of ethyl bromide, while the stabilization energies of the intermediate complexes and products are almost the same for chloride and bromide. Temperature in general has little effect on the reaction profile, with the exception of entropic destabilization of the initial complex. At the same time, the usage of a polar solvent accelerates the reaction process, lowering the barriers and stabilizing the intermediates, and can be recommended for carrying out the reaction.
Research of the crosswind effect on the single-rotor helicopter unintentional yaw rotation
Authors: Efimov V. V. , Ivchin V. A. , Chernigin K. O.
Published: August 2024

During the operation of single-rotor helicopters, aviation accidents quite frequently occur in the form of an unintentional turn or even a yaw rotation, causing, as a rule, a ground collision. Numerous researchers of this problem consider the loss of helicopter tail-rotor effectiveness due to wind effects as one of its possible causes. There is even a special term – the Loss of Tail Rotor Effectiveness (LTE) in the foreign literature. Hence, this paper deals with an attempt to determine the capacity of an unintentional single-rotor helicopter yaw rotation occurrence due to wind effects (the impact of the main rotor on the tail rotor was not considered in this paper). To solve this issue, theoretical methods (analytical calculations and computational experiments) were used. To carry out analytical calculations and computational experiments, a mathematical model of the Mi-8MTV helicopter yaw rotation dynamics was developed, on the basis of which a software package integrating the LTE module (for modeling the dynamics of rotational yaw motion of the helicopter) and OGL (for helicopter motion visualization) was created. Analytical calculations revealed that the yaw angular acceleration value monitored in-flight during an unintentional rotation can manifest itself due to the tail rotor thrust loss in the vortex-ring state. But for the development of an unintentional rotation to angles and angular velocities recorded in real flights, that kind of tail rotor thrust loss should occur during the entire turn. In computational experiments using the mentioned above software package, conditions failed to be created for that kind of thrust loss during the entire turn. Consequently, those yaw angles and angular velocities, that occurred in flights, could not be reached. The tail rotor, when blown by the wind in the investigated range of wind velocities (from 1 to 20 m/s) does not lose its effectiveness to such an extent that an unintentional rotation cannot be stopped by means of the tail rotor.
SPIRITUALLY WIRED: THE SCIENCE OF THE MIND AND THE RATIONALITY OF BELIEF/UNBELIEF
Authors: CLARK KELLY JAMES
Published: August 2024

I canvass a suite of psychologically-based arguments which aim to undermine rational religious belief. I argue that such arguments, from the God helmet to the God gene, overstate the evidence and fail to establish their conclusions. Moreover, the empirically better-supported cognitive science of religion, though in its infancy, is neutral with respect to the rationality of religious belief. I conclude with a discussion of the cognitive impulses to unbelief and argue, by analogy, that we should (epistemically) refrain from judgments of the rationality of religious belief or unbelief.
CONSCIOUSNESS AS A PREREQUISITE FOR SCIENCE AND RELIGION
Authors: TALIAFERRO CHARLES
Published: August 2024

A key concern philosophically today is how to square our common sense understanding of ourselves as intentional, conscious agents with a naturalist view of the cosmos, according to which the cosmos is non-teleological, non-purposive, and consisting of mind-less processes. One strategy has been for naturalists to deny the common sense understanding of ourselves. In this essay, the reality of conscious, intentionality is affirmed as being more certain than the existence and nature of mind-independent physical objects and events. Philosophers who in the name of science seek to eliminate consciousness do not appreciate that there cannot be science without scientists, conscious, purposive selves. Recognizing the primacy of consciousness blocks one naturalist strategy, leaving us open entertain non-naturalist accounts like theism, and some of the objections to theism can be countered once we recognize the robust reality of consciousness.
The Need for Merely Possible People
Authors: Gustafsson Johan
Published: August 2024

W. V. Quine wished to restrict the interests that matter to those of actual people. Actual-Population Utilitarianism is a version of utilitarianism whereby, following Quine, only the interests of actual people matter. It is well known that ethical theories of this kind, which depend on what is actual, typically lead to normative variance. In this paper, I put forward a new objection to Actual-Population Utilitarianism. I present a case in which Actual-Population Utilitarianism prescribes choices that are worse for everyone whose interests matter than the opposite choices. Moreover, I put forward a case in which total and average versions of Actual-Population Utilitarianism prescribe choices that are worse than the opposite choice for everyone (full stop). This objection also applies if the Actual-Population Restriction is combined with nonutilitarian views, given some minimal assumptions.
More on the Hybrid Account of Harm
Authors: Unruh Charlotte
Published: August 2024

According to the hybrid account of harm, an agent suffers harm if the agent has negative wellbeing or is worse off than before. However, Erik Carlson, Jens Johansson, and Olle Risberg have criticized the hybrid account, arguing that it finds harm where there is none in cases of temporary benefits and that it fails to find harm in the case of death. In this note, I defend the hybrid account against both criticisms.
Peculiarities of hemodynamic and microcirculation in children with recurrent bronchitis
Authors: Buriak O.H.
Published: August 2024

Background. Recurrent bronchitis in children is associated with respiratory symptoms and reduced lung function, which may influence overall health. Hemodynamic instability commonly observed in children with recurrent bronchitis. Cardiac output, blood pressure and heart rate are the principal hemodynamic parameters which could be affected. Bronchitis episodes often cause increased heart rates due to the body’s attempt to compensate for the reduced oxygenation, leading to an elevated cardiac workload and potentially heart failure in severe cases. Although the relationship between recurrent bronchitis and cardiovascular health has been studied in adults, but limited research exists on this topic in the pediatric population.

Purpose – to investigate the peculiarities of blood pressure and microcirculation in children with recurrent bronchitis.

Materials and Methods. A total of 60 children aged 7 to 12 years were enrolled in the study and divided into two groups: a main group of 30 children with recurrent bronchitis and control group of 30 healthy children. Inclusion criteria for the main group were a confirmed diagnosis of recurrent bronchitis for at least three times in two consecutive years. The cardiorespiratory parameters assessed included blood pressure, pulse rate, and respiratory rate. Nail bed capillary state was also evaluated to assess microcirculation. Monitoring of arterial pressure was performed using 24-hour ambulatory blood pressure monitoring device (ABPM).

Results. Children with recurrent bronchitis exhibited significantly higher blood pressure, pulse rate and respiratory rate compared to healthy controls. Furthermore, the main group demonstrated significantly higher daytime and nighttime blood pressure and increased blood pressure variability compared to the control group. Microcirculation disorders were observed in the majority of children in the main group. The main abnormalities of microcirculation were increased capillary tortuosity, decreased linear density and the presence of a sludge phenomenon.

Conclusions. Our findings suggest that recurrent bronchitis in children is associated with cardiovascular health impairment and microcirculation disorders. Early detection and monitoring of these parameters may help mitigate the long-term consequences on cardiovascular health in children with recurrent bronchitis.
Upaya memasyarakatkan astronomi melalui OIF Goes To School di Sekolah MIN 12 Medan
Authors: Putraga Hariyadi , Panjaitan Nur Nilam Sary , Nasution Makromatul afifah , Ritonga Marataon , Rakhmadi Arwin Juli
Published: August 2024

Astronomi lahir dari kebutuhan masyarakat dalam pencarian penanda waktu dan arah. Namun, masyarakat sendiri belum banyak yang mengenal fenomena astronomi dan cenderung lupa bahkan tidak mengetahui tentang fenomena tersebut. Upaya mengenalkan astronomi kepada masyarakat merupakan salah satu solusi yang dilakukan oleh peneliti yang bekerjasama dengan OIF UMSU masih sebatas di sekolah dilakukan dengan memanfaatkan Program OIF Goes to School di Kota Medan. Program yang dilakukan adalah Sosialisasi dan mengedukasi masyarakat tentang fenomena astronomi, pengamatan matahari dengan teleskop dan kacamata matahari, serta instrumen Astronomi lainnya yang dibawa saat kegiatan berlangsung. Dari program yang dilakukan, masyarakat memberi respon melalui kuisioner dengan skala likert. Respon masyarakat sangat baik, dengan nilai rata-rata sebesar 3,71. Sebanyak 96% responden menyatakan perlu selalu diadakan kegiatan ini kembali.
PENYULUHAN PANGAN SUMBER PROBIOTIK DAN OLAHAN YOGURT SEBAGAI BEKAL BERWIRAUSAHA BAGI SISWA SMA MUHAMMADIYAH 4 KENDAL
Authors: Fitriana Ika , Cahyanti Nani , Sampurno Adi
Published: August 2024

Implementasi tentang probiotik dan kontribusinya  dalam menanggapi tantangan kesehatan masyarakat. SMK Muhammadyah 4 Kabupaten Kendal memiliki usaha ternak sapi dan kambing perah, potensial dibuat yogurt. Tim Fakultas Teknologi Pertanian Universitas Semarang melakukan kegiatan PKM dalam bentuk penyuluhan dan praktek sederhana pembuatan yogurt susu sapi. Siswa peserta diberikan pre-test untuk mengukur baseline pengetahuan dasar mengenai materi penyuluhan. post-test untuk mengetahui sejauh mana siswa dapat memahami materi penyuluhan. Kegiatan diikuti oleh 44 siswa dan 5 guru. Nilai rerata pre-test sebesar 5,08 < nilai rerata post-test; secara deskriptif terdapat perbedaan = 0,76 atau rerata nilai post-test lebih tinggi 0,76 daripada nilai pre-test dengan nilai signifikansi 0,165 (p>0,05); nilai post-test tidak berbeda secara signifikan dengan nilai pre-test. Kesimpulan materi yang diberikan merupakan hal yang baru sehingga diperoleh hasil dasar pemahaman awal tentang materi kegiatan yang sama dengan pemahaman akhir.
Penyusunan LKPD Matematika Terintegrasi Nilai Islam Menggunakan Canva Di MI Islamiyah Pancakarya Semarang
Authors: Maulana Charis , Kusumaningrum Yulinda , Ulami’ M. Dliya’
Published: August 2024

Matematika sering dianggap sulit karena sifatnya yang abstrak. Mengintegrasikan nilai-nilai Islam dalam pembelajaran matematika dapat membuatnya lebih menarik dan relevan, serta menumbuhkan karakter Islami pada peserta didik. Di MI Islamiyah Pancakarya Semarang, penggunaan media pembelajaran dan teknologi seperti Canva untuk menyusun Lembar Kerja Peserta Didik (LKPD) yang terintegrasi nilai Islam masih belum optimal. Oleh karena itu, tim pengabdian memberikan pelatihan kepada guru-guru untuk menyusun LKPD matematika yang terintegrasi nilai Islam menggunakan Canva. Pelatihan ini diselenggarakan melalui metode pelatihan dan praktik langsung agar guru mampu menyusun LKPD matematika yang terintegrasi nilai Islam menggunakan Canva. Tujuan dari kegiatan ini adalah untuk meningkatkan pemahaman dan kemampuan guru dalam menyusun LKPD matematika yang terintegrasi nilai Islam menggunakan Canva. Hasil kegiatan ini menunjukkan respon positif dari para guru, yang ditandai dengan meningkatnya motivasi mereka untuk menyusun LKPD matematika yang terintegrasi nilai Islam menggunakan Canva.

Kata Kunci: canva, integrasi nilai Islam, LKPD, pembelajaran matematika
The resilience of youth entrepreneur: the role of social capital, financial literacy, and emotional intelligence on SMEs’ performance in Indonesia
Authors: Worokinasih Saparila , Nuzula Nila Firdausi , Damayanti Cacik Rut , Sirivanh Thongvanh
Published: August 2024

This paper aims to investigate factors that contribute to strengthening the business performance of youth entrepreneurs. Based on the Resource-Based Theory (RBV), this study examines the social capital, financial literacy, and emotional intelligence of small and medium-sized business (SME) youth owners' effect on business performance. The link between the variables is evaluated using the Partial Least Square – Structural Equation Modelling (PLS-SEM). The findings demonstrated that youth entrepreneurs' social capital and financial literacy positively and significantly affect emotional intelligence. At the same time, SME performance was directly influenced by the youth owner's emotional intelligence. Based on the research, SME youth owners are urged to strengthen their emotional intelligence to make prudent business choices that would significantly enhance their firm's success. Also, maintaining the relationship and upgrading their financial literacy could indirectly enhance business performance. Managers in SMEs must understand the link between social capital, financial literacy, and emotional intelligence to improve performance. Cultivating strong business networks and relationships, ensuring sound financial practices, and fostering emotionally intelligent leadership can drive stronger business performance and maintain a competitive advantage.
Establishing collaboration and knowledge sharing as a fear of missing out response in improving tourist travel agency innovation performance
Authors: Hamdan Hamdan , Yuliantini Tine , Raharja Indra , Samudro Amzad , Ali Hapzi
Published: August 2024

The FoMO phenomenon usually occurs in individual behaviour on social media. However, recent research in the industrial context has investigated anxiety, fear of being left behind, fear of losing market advantage, and fear of losing competitiveness. This reinforces the still rare term FoMO as an important antecedent of business performance. Highlighting FoMO, as prior research has been limited, is the best way to fill the gap. As a result, an exploratory approach is used, and selecting the SEM-PLS analysis method is the right approach because it is predictive. The results of this study reveal that both direct and indirect effects between FoMO, intention to collaborate, intention to share knowledge, and innovation performance can be accepted and justified empirically. In addition, the mediator of the intention to collaborate is the one that contributes the most to influencing FoMO on the intention to share knowledge. Afterward, the mediator from the intention to share knowledge influences the intention to collaborate on innovation performance. This study confirms that the FoMO concept embedded in the minds of travel agency entrepreneurs is meaningful for success towards competitive innovation performance through the intention to collaborate and share knowledge.
The promise of blockchain: analysing potentials and barriers in supply chain management
Authors: Sinniati Sinniati , Darma Gede Sri
Published: August 2024

This study explored the potential and barriers to implementing blockchain technology in Supply Chain Management (SCM). The purpose of the research was to determine the potential of implementing blockchain technology to enhance SCM performance, identify the challenges faced in implementing blockchain in SCM, and understand the constraints and obstacles that need to be overcome for successful implementation. The research method applied was a Systematic Literature Review (SLR) using the PRISMA protocol and the PICOC framework, with 73 papers collected from 2018 to June 2023. The study identified blockchain's potential to revolutionise SCM by enhancing traceability, transparency, efficiency, trust, and security. It also found that blockchain could support sustainability and anti-counterfeiting efforts. However, significant barriers exist, including technological challenges like immaturity, complexity, and scalability issues, as well as organisational and environmental hurdles such as lack of knowledge, high costs, and insufficient government regulation. To fully realise blockchain's benefits in SCM, stakeholders must address these barriers through targeted investments, fostering industry-wide collaboration, and establishing clear regulatory frameworks.
Pengembangan LKPD Berbasis Cooperative Learning Pada Materi Pluralitas Masyarakat Indonesia Untuk Meningkatkan Kemampuan Kerjasama
Authors: Purwaningsih Wiwik
Published: August 2024

Tujuan penelitian ini untuk mengembangkan LKPD berbasis cooperative learning pada materi Pluralitas Masyarakat Indonesia yang digunakan secara layak, praktis, dan mampu meningkatkan kemampuan kerjasama bagi peserta didik kelas VIII SMP. Metode penelitian ini ialah Research and Development (R&D) dengan model pengembangan 4D Thiagarajan. Penelitian ini dilaksanakan di SMP Negeri 45 Surabaya. Populasi dari penelitian ini adalah peserta didik kelas VIII SMP Negeri 45 Surabaya, dengan sampel penelitian peserta didik kelas VIII B. Berdasar pada hasil penelitian dapat diketahui bahwa (1) LKPD dinyatakan layak dari validator dalam segi media – desain (78,57%), segi materi (78,66% & 54,66%), dan segi bahasa (86% & 100%), (2) Secara praktis LKPD dinyatakan sangat baik ialah 91,66% (Respon Guru) dan 84,77% (Respon Peserta Didik) yang dilihat dari keterlaksanaannya, (3) Peningkatan kemampuan belajar peserta didik dapat dilihat dari rata – rata pertemuan I sebesar (31,4%), Pertemuan II sebesar (34,73%), Pertemuan III sebesar (38,46%), dan Pertemuan IV sebesar (39,9%). Dari hasil penelitian tersebut dapat disimpulkan bahwa LKPD berbasis cooperative learning pada materi Pluralitas Masyarakat Indonesia dapat digunakan secara layak dan praktis dalam meningkatkan kemampuan kerjasama peserta didik.
Pengaruh Penggunaan Model Pembelajaran Berpikir Induktif (Thinking Inductively) Terhadap Kemampuan Berpikir Kritis Peserta Didik Pada Pembelajaran IPS
Authors: Supriadi Andika , Suprijono Agus , Imron Ali , Marzuqi Muhammad Ilyas
Published: August 2024

Pendidikan merupakan sebuah kunci dari kehidupan, pendidikan menjadi sektor vital demi memajukan sebuah negara, negara yang maju dapat dinilai dari tingkat kependidikan dari bangsanya. Era pendidikan tak luput dari berjalannya waktu demi waktu, terlebih di era globalisasi saat ini berbagai kompetensi diperlukan demi memenuhi kebutuhan dalam kehidupan nyata, salah satu kompetensi yakni 4C, (Critical Thinking, Creative Thinking, Collaboration, and Communication). Sehingga dalam kebutuhannya, sektor pendidikan menjadi peran penting dalam memenuhi keterampilan yang dimiliki oleh para peserta didik guna memenuhi kebutuhan di dalam kehidupan setelah sekolah. Sehingga dalam pengelolaan model pembelajaran guru dituntut untuk dapat berinovasi dan berkreativitas dalam mengembangkan model pembelajaran Penelitian ini merupakan jenis penelitian kuantitatif dengan menggunakan pendekatan Quasi Eksperimental Design dengan model Non-equivalent Control Group Design. Dengan menggunakan sampel Peserta Didik kelas VIII E dan F SMP Muhammadiyah 2 Taman. Yang mana kelas VIII-F sebagai kelas eksperimen dan VIII-E sebagai kelas kontrol. Teknik pengambilan sampel yang peneliti gunakan adalah nonprobability sampling yang berjenis cluster sampling purposive dengan pertimbangan tertentu. Berdasarkan pada uji hipotesis yang telah dilakukan penelitian ini menunjukkan adanya pengaruh penggunaan model pembelajaran berpikir induktif (Thinking Inductively) terhadap kemampuan berpikir kritis pada peserta didik berdasarkan pada uji Mann Whitney.  Dari hasil uji Mann Whitney didapatkan nilai Sig. 0,000 sehingga Ha dapat diterima. Dapat disimpulkan bahwa model pembelajaran berpikir induktif berpengaruh terhadap kemampuan berpikir kirtis pada peserta didik
Problematika Internalisasi Pendidikan Karakter Dalam Pembelajaran IPS SMP Pasca Pandemi (Studi Fenomenologi Di MTS Ma'arif Ketegan Tanggulangin)
Authors: Haryanti Novalia Suci , Setyawan Katon Galih , Setyawan Katon Galih , Niswatin Niswatin , Prastiyono Hendri
Published: August 2024

Kondisi global sekolah pada saat pandemi Covid-19 membuat pemerintah memberikan kebijakan pembelajaran daring sehingga berdampak pada kemerosotan nilai karakter peserta didik. Penelitian ini bertujuan untuk menjelaskan apa saja problematika dalam internalisasi pendidikan karakter dalam pembelajaran IPS SMP pasca pandemi di MTs Ma’arif Ketegan. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan mengunakan perspektif fenomenologi. Pemilihan jenis penelitian tersebut disebabkan oleh beberapa faktor yang diutamakan dalam penjelasan serta penjabaran suatu fenomena yang akan diteliti. Dengan menggunakan metode penelitian ini, perspektif fenomenologi digunakan untuk mengurangi pengaruh subjektifitas yang dapat menjadikan sumber terjadinya penyimpangan, bias, dan ketidaktepatan informasi yang nantinya didapatkan di lokasi penelitian. Hasil penelitian menunjukkan bahwa adanya problematika dalam internalisasi pendidikan karakter dalam pembelajaran IPS SMP Pasca pandemi di MTs Ma’arif Ketegan dilatarbelakangi oleh kesulitan-kesulitan yang dialami oleh peserta didik akibat pandemi Covid-19 seperti penurunan kondisi perekonomian keluarga setelah pandemi, adanya perceraian orangtua yang dialami oleh peserta didik akibat penurunan kondisi ekonomi, kehilangan orangtua sehingga kurangnya perhatian, dan tidak diberikannya pendidikan karakter didalam lingkungan keluarga.
Jacobson’s Distinctive Features and the Analysis of assimilation in Kurdish Bahdini local dialect
Authors: Yaseen Mohammed Kasar , Hassan Mohammed Hamdiya
Published: August 2024

Distinctive Features are generally used to describe the smallest units of sound in both phonetic and phonological analyses which aims to differentiate between the meaning of one word and another in a certain language. The topic of distinctive features has always caught the interest of phonologists and many schoolars used these features as the smallest units of sounds in order to describe sound features in all human languages. This research is an attempt to represent the distinctive features of Kurdish language, as well as to explain assimilation through Jacobson,s Distinctive Features in order to reach some phonological rules in Kurdish language. Samples are taken and analysed from revels written by speakers from the center of Duhok in order to represent the distinctive features of the sounds which affect the adjacent sounds, as well as creating the rules of the sounds which affect each other. Jacobson’s features are mainly based on a acoustic description of sounds.
The most important hypotheses of this research show that this theory meets the following requisitions:  Distinctive Features (DFs) can describe a natural class of sounds. They can also describe the distinctions of  sounds in all languages of the world and these features can be defined phonological. In conolusion it is clear that in Bahdini local dialect, The changes often affect the sound which carries the feature (±voiced) of stop and fricative sounds in general, and upon the feature (+voiced) of fricative in novel particularly.
Etnografia na implementação de políticas públicas educacionais
Authors: Rosistolato Rodrigo , Prado Ana Pires do , Martins Leane Rodrigues
Published: August 2024

O artigo analisa as especificidades metodológicas da realização de etnografias na implementação de políticas públicas educacionais. Apresentamos uma pesquisa que teve como proposta a realização de uma etnografia coletiva, na qual trabalhamos em equipe e organizamos conjuntamente os procedimentos relacionados às imersões etnográficas. Argumentamos que o olhar etnográfico e a observação participante são caminhos para o conhecimento sobre a construção cotidiana de uma política, assim como para o mapeamento dos contextos e das configurações de interação entre os burocratas responsáveis pela implementação e os cidadãos. Elas permitem a análise dos procedimentos e das ações discricionárias dos agentes em contextos de implementação.
Metode Stationlernen dalam Peningkatan Keterampilan Menulis Karangan Sederhana Bahasa Jerman
Authors: Salombe Mersiana , Anwar Muhammad , Jufri Jufri
Published: August 2024

Abstract. This research aims to improve the German simple text writing skills of class XI students of SMAN 14 Gowa using the Stationlernen learning method. This research is a classroom action research consisting of two cycles, each cycles consists of planning, implementation, observation and reflection. The research subjects were the students of class XI IPA 1 which amounted to 36 Students. The data of this research consisted of qualitative and quantitative data. Qualitative data is obtained from the results of teacher and student observations while quantitative data is obtained through simple text writing skills test in cycle I and cycle II. The results of the student’s German simple text writing test in cycle I obtained an average of 61,51 and increased in cycle II with an average score 81,35. The results of this research indicate that the application of the Stationlernen learning method can improve the German simple text writing skills of students of class XI SMAN 14 Gowa.Keywords: Learning Methods, Writing Skills, Simple Text, Stationlernen
POTENSI DESTINASI WISATA OLAHRAGA PADA DESTINASI WISATA PUNCAK PATO KABUPATEN TANAH DATAR
Authors: Hidayat Taufik
Published: August 2024

Tujuan penelitian dalam artikel ini membahas bagaimana potensi wisata Olahraga pada Puncak Pato Kabupaten Tanah Datar Sumatera Barat. Adapun poin-poin yg penulis lihat pada penelitian ini merupakan Wisata Olahraga sebagai potensi wisatawan, fasilitas wisata & aksesibilitas. Metode yg dipakai merupakan naratif & partisipasi. Metode pengumpulan data observasi, wawancara terstruktur, & dokumentasi. Penelitian ini memakai metode deskriptif kualitatif yaitu analisis secara interpretatif memakai teori atau literatur yg sesuai, lalu secara induktif menarik konklusi menjawab pertanyaan. Hasil penelitian menyebutkan mengenai Potensi Wisata Olah Raga Puncak Pato, Fasilitas & Aksesibilitas objek wisata. Katakunci: Sport Tourism, Event, Pariwisata, Puncak Pato
Analisa Strategi Pemasaran di Rimbun Kopi Batam dalam Meningkatkan Jumlah Pengunjung
Authors: Soraya Giska , Alhamdi Rezki
Published: August 2024

Saat ini, banyak sekali bidang usaha makanan dan minuman yang berusaha bertahan dengan cara melakukan strategi pemasaran yang tepat. Strategi pemasaran harus dilakukan dengan efektif sehingga dapat meningkatkan pengunjung maupun keuntungan. Aktivitas bauran pemasaran mempunyai peranan penting bagi kelangsungan hidup suatu bidang usaha. Rimbun Kopi adalah salah satu bidang usaha makanan dan minuman yang cukup terkenal dikalangan masyarakat. Rimbun Kopi berusaha mempertahankan eksistensi usahanya dengan menggunakan strategi pemasaran yang tepatTujuan penulisan proyek akhir ini adalah untuk menganalisa strategi pemasaran Rimbun Kopi dalam meningkatkan jumlah pengunjung. Masalah yang di bahas adalah bagaimana minat pengunjung untuk datang kembali ke Rimbun Kopi serta bagaimana strategi pemasaran yang di gunakan Rimbun Kopi dengan menggunakan marketing mix 7P product, price, place, promotion, people, process, physical evidence. Metode yang penulis gunakan dalam penulisan proyek akhir ini adalah metode deskriptif kualitatif. Hasil dari penelitian tugas akhir ini bahwa pengunjung melakukan pembelian ulang sekaligus datang kembali ke Rimbun Kopi sebagai pelanggan. Untuk strategi pemasaran marketing mix 7P yang digunakan oleh Rimbun Kopi cukup efisien dan memberikan hasil yang cukup memuaskan bagi Rimbun Kopi. Keywords: Pariwisata, Strategi pemasaran, Marketing mix 7P, Rimbun Kopi
Contribution of Professor P.M. Belyanchikov to the tractor industry development in the USSR
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Sharov Vladimir V.
Published: August 2024

Pavel Mikhailovich Belyanchikov was one of the most prominent scientists who actively participated in the development of the domestic tractor industry, but remained practically unknown to the modern generation. In order to assess the contribution of Professor Belyanchikov to the science of tractors and the development of the domestic tractor industry, the author analyzed the archival materials kept in the Museum of Agricultural Mechanics named after V.P. Goryachkin, as well as scientific and technical literature and periodicals. It should be noted that Pavel Belyanchikov was one of the first in our country to develop methods, programmes and write textbooks for teaching students the construction and operation of tractors. Using the results of tractor equipment tests, he prepared for publication analytical materials that initiated the birth of the domestic science of tractor designing. His scientific and technical materials were used by E.D. Lvov when he wrote the first book in our country on tractor theory “Tractors: Design and Calculation of Parameters”. In 1927, Pavel Belyanchikov headed the jury of the All-Russian Tractor Testing Committee, which selected the best tractor models suitable for mass production in the USSR. Pavel Belyanchikov’s scientific and pedagogical activity was interrupted by repressions in 1930. As time went by, his name was no longer mentioned in publications and he gradually fell into oblivion. Remembering and evaluating the scientific outcomes of P.M. Belyanchikov’s research activity, we should note their theoretical and practical value. He laid the foundation for the “Tractors and Automobiles” discipline, determined the development trends of the domestic tractor industry and offered new tractor designs.
Perancangan Dan Pembuatan Alat Uji Keras Pin Brinell Portabel ASTM E10 Serta Percobaan Pengujian Kekerasan Pelat Baja SS400
Authors: Irvani Pria , Putra Hardyansyah Satria , Akuan Abrianto , Mashudi Mashudi
Published: August 2024

Ilmu untuk mengetahui sifat mekanik material salah satunya pengujian kekerasan menjadi
metode paling efisien karena melalui proses ini, kita dapat dengan cepat memahami karakteristik
mekanis suatu bahan. Uji kekerasan juga merupakan salah satu pendekatan untuk mengevaluasi dampak
perlakuan panas atau dingin terhadap material. Kekerasan suatu material dapat diuji dengan berbagai
metode, salah satunya adalah metode Brinnel. Penelitian ini bertujuan untuk merancang dan membuat
alat uji kekerasan Pin Brinell portabel sesuai dengan standar ASTM E10. Perancangan dan pembuatan
alat uji kekerasan portable ini juga untuk tambahan fasilitas di Laboratorium Teknik Mesin Universitas
Nahdlatul Ulama Blitar.
Perancangan alat uji keras Pin brinel Portabel sesuai standar ASTM E10. Komponen-komponen
utama alat uji keras ini adalah housing, cover, as pin, pegas, specimen pembanding dan bola baja.
Material yang digunakan adalah baja S45C untuk housing dan cover serta material chrome vanadium
untuk as pin. Dimensi total alat uji memiliki diameter 50 mm dan Panjang 220 mm. Penggunaan alat uji
keras Pin Brinell Portabel pada percobaan pengujian kekerasan terhadap pelat baja SS400 yang
dilakukan sebanyak 3 kali pengujian, didapatkan hasil nilai kekerasan: 149.7 HB (147.43 HV) dan
didapatkan nilai kekuatan luluh sebesar: 335.29 MPa dan kekuatan tarik sebesar: 438.22 MPa.
Implementasi Nilai-nilai Pendidikan Islam dalam Seni Teater SKA 1
Authors: Aminah Jefni Rawandi
Published: August 2024

Penelitian ini mengkaji tentang 1) Implementasi nilai-nilai pendidikan Islam dalam seni teater SKA1. 2) faktor pendukung dan penghambat implementasi nilai-nilai pendidikan dalam seni teater SKA1. 3) dampak dari implementasi nilai-nilai pendidikan Islam dalam seni teater SKA1. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian kualitatif deskriptif. Pengumpulan data dilakukan dengan cara wawancara, observasi dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini yaitu reduksi data (data reduction), penyajian data (data display), dan penarikan kesimpulan atau verifikasi. Berdasarkan hasil penelitian menunjukan bahwa Implementasi nilai-nilai pendidikan Islam dalam seni teater SKA1 itu membantu karakter santri terbangun menjadi pribadi yang percaya diri dengan berlandaskan pendidikan yang islami. Santri terhibur dan dapat mengasah imajinasi mereka secara baik dan benar, mensuritauladani kisah-kisah para nabi melewati surah-surah dalam Al-Quran. Dampak dari implementasi ini seluruh pelajaran yang berbasis agama Islam bisa diimplementasikan secara visual melewati dengan berseni teater.
The Influence of Side-Slip Velocity on Subsurface Displacement
Authors: Ronoatmojo Imam Setiaji , Burhannudinnur Muhammad , Sutadiwiria Yarra , Syavitri Dewi
Published: August 2024

This research aimed to determine the influence of side-slip velocity on subsurface displacement during seismic data acquisition. Anisotropy constants were used to determine the depth migration process before stack, which showed inadequate results after data validation. Therefore, the forward modeling of a medium, which comprised anisotropy constants of normal and offset raytracing was conducted to address this problem. The configuration of source to receiver were orthogonal and slant. The results showed that the migration process failed to resolve the geological structures of the position shifting. The configuration of source to receiver were orthogonal and slant. The results show the better continuity of slant and the influence of complex geological structures controls the position shifting, which could not be resolved by the migration process. It could be seen from the random distribution of the normal shift of group velocity and phase velocity, as well as the CDP – CRP shift. It produced wave azimuth rotation in a discontinuity plane, such as fault and anticline ridge. This azimuth rotation was strongly suspected to cause inaccurate anisotropy constants implementation in pre-stack depth migration process
Pengembangan Teknologi Informasi di Dunia Kesehatan dan Pendidikan
Authors: Katulistiwa Nariyah Koriyota , Nata Dirgantara Putra Wahdana  , Nitya Nabilah Nariswari  , Nur Diana Hamidah  , Nur Mufidah
Published: August 2024

The development of technology and information is common in the digital age. Online media as a form of sophistication of information and communication technology plays a big role in human life, one of which is in improving health services. Based on the background above researchers are interested in conducting this study entitled "Development of Information Technology in the World of Health and Education". This study uses a method of review literature. In this study obtained results that there are various examples of the use of technology in health such as halodokter websites used in counseling and credible sources of health information, in addition to the development of technology requires nurses to be able to compensate with the level of technology that exists by increasing knowledge and sharing knowledge of fellow nurses. In education virtual simulation plays a role in mental nursing education, which is accessible, convenient, and safe to practice skills because the methods of using curriculum setting programs and outcome of competencies vary.
Knowledge Level with Community Compliance in Implementing Covid-19 Prevention Health Protocols
Authors: Dya Sustrami  , Sari Ninik Ambar Sari , Hidayatus Sya’diyah  , Dedi Irawandi
Published: August 2024

Covid 19 is a type of virus that spreads very quickly or infects other people. Most Indonesians do not comply with the government's recommendation to comply with health protocols. The purpose of this study was to analyze the level of knowledge with compliance in the Covid-19 health protocol. This study used a cross sectional approach. Samples were taken by accidental sampling technique as many as 154 people in RW 03 Manukan Kulon Village, Surabaya City. The variable level of knowledge and compliance instrument used a questionnaire. Data were analyzed using Spearman Rho's test with a significance degree of 0.05. The results showed that there was a relationship between the knowledge level variable (0.040) and compliance with the Covid-19 health protocol in RW 03, Manukan Kulon Village, Surabaya. The level of knowledge is very influential on compliance in carrying out health protocols. The implication of this study is that the level of knowledge affects the community's compliance with health protocols.
Penurunan Respons Ansietas Klien Penyakit Fisik Dengan Terapi Generalis Ansietas Di Rumah Sakit Umu Bogor
Authors: Nasywaa Fauzi Salsabila , Segita Citra Ferliensyah  , Siprianus Palbeno  , Yolla Yohanna Febryantie
Published: August 2024

Penyakit Ansietas klien yang dirawat di rumah sakit karena penyakit fisik ditandai dengan rasa tidak nyaman, sedih, gelisah, khawatir. Karya ilmiah ini bertujuan untuk melaporkan penerapan terapi generalis terhadap tanda gejala klien ansietas dengan penyakit fisik. Metode yang digunakan adalah deskriptif analitik melalui pendekatan model stres adaptasi Stuart dan konsep “Caring” Swanson terhadap 100 klien yang dirawat di rumah sakit umum. Penerapan terapi generalis menurunkan respons kognitif (25), afektif (57), fisiologis (38), perilaku (42), dan sosial (46). Direkomendasikan terapi generalis untuk diberikan pada klien ansietas dengan penyakit fisik di rumah sakit umum.
PREMATURE AGING (INFLAMAGING) AND DISEASES OF THE FEMALE REPRODUCTIVE SYSTEM
Authors: Shteiman A.A. , Krylova Yu.S. , Dokhov M.A. , Zubareva T.S. , Leonteva D.O. , Botina A.V. , Tikhomirova A.A.
Published: August 2024

Relevance. The review is devoted to the issue of aging and the relationship of the molecular processes of aging with the pathology of the reproductive system The aim of the study was to review the current understanding of aging, the mechanisms and role in the pathology of diseases such as endometriosis, premature ovarian failure and to find possible potential points of treatment. Material and methods: the analysis and systematization of literature over the past 5 years in the PubMed, Scopus and Google Scholar databases was carried out. Results. The review reflects the main mechanisms involved in the aging of the reproductive system, the impact on which is possible both by medication and by modifying lifestyle and nutrition. What can make it possible to reduce the number of side effects from the use of the main, hormonal, treatment
FEATURES OF EXPERIMENTAL OSTEOARTHROSIS CAUSED BY DEXAMETHASONE AND TALC
Authors: Osmanova S.O. , Osmanov O.O. , Alimkhanova A.A.
Published: August 2024

Introduction. An experimental study of the pathogenetic mechanisms of the development of inflammatory-destructive changes in the joints in animal models was carried out in order to develop new diagnostic strategies for further implementation of the results obtained in clinical practice, determination of morphometric and metabolic features of the skeletal connective tissue of the rat knee joints.
Material and methods. The authors studied histological preparations of knee joints stained with Mayer’s hematoxylin and eosin, alcian blue (pH 1.0 and 2.5) according to Van Gieson, Masson and Mallory. The metabolic properties of cartilage and bone tissue were studied by determining the concentration of hyaluronic acid, osteocalcin, and type I collagen in the blood serum of laboratory animals.
Results. In rats with osteoarthritis induced by the administration of dexamethasone and talc, a 50% decrease in the thickness of the articular cartilage in its loaded areas was noted. There was also a violation of the spatial distribution of chondrocytes, a decrease (p<0.01) in the nuclear-cytoplasmic ratio of chondrocytes to 0.3 and an increase in the serum concentration of hyaluronic acid (p<0.001) to 110.2 ng/ml, fragments of type I collagen (p<0.001) to 217.9 ng/ml and osteocalcin (p<0.001) to 231.1 ng/ml.
Conclusion. The main pathogenetic features of experimental osteoarthritis induced by dexamethasone and talc are a violation of the density of distribution, morphological features and functional activity of chondrocytes. All this leads to inhibition of the synthesis of the components of the extracellular matrix of the articular cartilage, and is also accompanied by the activation of the destruction of proteoglycans containing non-sulfated glycosaminoglycans.
Molecular mechanisms of tumor drug resistance
Authors: Okladnikova E.V. , Zinchenko I.S. , Ruksha T.G.
Published: August 2024

Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell during its transformation into a malignant one can lead to the development of primary resistance whereas secondary resistance occurs already as a result of treatment with anticancer drugs. The purpose of the review. To summarize current data on the mechanisms of a drug resistance development to chemotherapeutic agents in order to select and implement possible ways to overcome it. Material and methods. The materials were the results of research on this topic over the past 15 years, from 2007 to 2022. The publications included in the databases PubMed, Medline, EMBASE were analyzed. Results. Analysis of the research results showed that among the mechanisms of a drug resistance development, there are changes in the activity of energy and metabolic processes, structural and/or functional alterations in the expression and function of cancer-related genes and proteins. All together it can lead to a disruption in the flow of the drug into the cancer cell, its active removal from the cell and the patient’s body, an insufficient, short-lived or perverted reaction of the malignant tumor to the drug. At the same time, the heterogeneity of primary tumor cells and metastatic cells leads to multiple mechanisms of drug resistance development in the same patient or in different patients with the same histological type of tumor. Overcoming or blocking some mechanisms of resistance can lead to the development of others. Conclusion. The study of the cancer cell drug resistance will help to optimize pharmacotherapy and improve the quality and life expectancy of patients suffering from cancer.
STUDYING THE RELATIONSHIP OF IRON CONCENTRATION IN BLOOD SERUM WITH FERRITIN, TRANSFERRIN AND OTHER CHEMICAL ELEMENTS
Authors: Morozova G.D. , Sadykov A.R. , Logvinenko A.A. , Namiot E.D. , Yurasov V.V. , Skalny A.V.
Published: August 2024

Introduction. Iron is an essential component of key metabolic processes in the body. Transferrin and ferritin are the main compounds that affect serum iron levels. For a competent diagnosis of iron metabolism disorders, knowledge of the principles of various analytical techniques is necessary. It is necessary to consider the interactions between iron and other chemical elements that affect the metabolism of iron in the body. The aim of the study. The aim of the study was to study the relationship between the iron concentration measured by the standard method and the ICP-MS method, with the indicators of ferritin and transferrin in blood serum; study of correlations of iron with other elements in blood serum. Material and methods. The study was conducted using a database of laboratory tests. In the blood serum of the examined, ferritin, transferrin, iron were measured by the ICP-MS method, the iron colorimetric method (6786, 1809, 13161, 10073 laboratory tests, respectively), as well as other chemical elements by the ICP-MS method. The relationship between the indicators was assessed using the Spearman rank correlation coefficient. Results. It was shown that the traditionally accepted relationships between the concentrations of iron and ferritin, transferrin are not manifested in the entire range of concentrations of these proteins. At different concentrations of transferrin and ferritin, certain patterns of changes in the concentration of serum iron in men and women were revealed. Statistically significant correlations of iron concentrations in blood serum with zinc, vanadium, selenium, nickel, manganese, magnesium, potassium, iodine, copper, chromium, cobalt, cadmium were determined. Conclusion. On a large sample the relationship of iron concentrations in blood serum with ferritin, transferrin, and other chemical elements was studied. It is necessary to evaluate the results of measurements of iron metabolism, taking into account the gender of the subject and the presence of interelement interactions.