bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Chlamydia trachomatis Genotypes in Endocervical Specimens by Sequence Analysis of ompA Gene among Women in Tehran
Authors: Rajabpour Mohammadreza , Emamie Amir Darb , Pourmand Mohammad Reza
Published: July 2023

Tehran’s actual prevalence of Chlamydia trachomatis (CT) and its genotypes are still unclear. Molecular typing of CT strains can provide essential epidemiological knowledge and contribute to improved control measures. In this study, we aimed to determine the prevalence of CT and its genotypes in the endocervical infections of females who attended the gynecology and infertility clinics in Tehran. A total of 291 women were tested for chlamydial infection by in-house PCR using specific primers for the CT cryptic plasmid. Nested PCR for amplification of the ompA gene in positive samples was carried out, genotyping was performed by sequencing this gene, and further phylogenetic analysis was conducted. Sexual infection by CT was observed in 10.3% (30/291) of the subjects, and the mean age of patients was 30.4. The ompA gene was sequenced in 27 samples, revealing E genotypes 40.7%, (n = 11), F 25.9%, (n = 7), G 18.5%, (n = 5), D 11.1%, (n = 3), and K 3.7%, (n = 1). This study emphasizes the importance of the diversity among CT genotypes in our studied population and the need for wide-screening the neglected bacterial infection among women in Tehran.
Supplementary Data from Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis
Authors: Ghosh Santanu , Yang Rachel , Duraki Darjan , Zhu Junyao , Kim Ji Eun , Jabeen Musarrat , Mao Chengjian , Dai Xinyi , Livezey Mara R. , Boudreau Matthew W. , Park Ben H. , Nelson Erik R. , Hergenrother Paul J. , Shapiro David J.
Published: July 2023

Supplement corrected to show label: 1 Supplementary Table
Supplementary Table 1 from Multicellular complex tumor spheroid response to DNA repair inhibitors in combination with DNA-damaging drugs
Authors: Dexheimer Thomas S , Coussens Nathan P , Silvers Thomas , Wright John , Morris Joel , Doroshow James H. , Teicher Beverly A.
Published: July 2023

Table S1. Top-ranking drug combinations by mean Bliss matrix score.
Supplementary Figure 4 from Multicellular complex tumor spheroid response to DNA repair inhibitors in combination with DNA-damaging drugs
Authors: Dexheimer Thomas S , Coussens Nathan P , Silvers Thomas , Wright John , Morris Joel , Doroshow James H. , Teicher Beverly A.
Published: July 2023

Figure S4. Heat maps of Bliss synergy scores across the combination dose-response matrices for all twenty-six cell lines grown as multicellular complex spheroids exposed to each DNA damaging agent (A, TMZ; B, topotecan; C, trabectedin) in combination with ATR inhibitors, berzosertib or elimusertib.
Supplementary Figure 1 from Multicellular complex tumor spheroid response to DNA repair inhibitors in combination with DNA-damaging drugs
Authors: Dexheimer Thomas S , Coussens Nathan P , Silvers Thomas , Wright John , Morris Joel , Doroshow James H. , Teicher Beverly A.
Published: July 2023

Figure S1. Representative brightfield images for assay optimized cell densities from a DMSO-treated well on Day 10.
Suppl Figure S12 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S12 shows the Frequencies of tumor-infiltrating immune cells in tumors treated with celecoxib or CAY10678 as monotherapy or combined with and PD-1 blockade
Suppl Figure S11 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S11 shows the effect of CAY10678 on the production of arachidonic acid metabolites from murine BrafV600E melanoma cells
Table S8 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Neopeptides (9mer) associated with INDELS in HCC
Suppl Figure S10 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S10 details the distribution of tumor-infiltrating immune cells in tumors derived from ptgs2-KO and ptges-KO murine BrafV600E melanoma cells
Table S7 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Neopeptides (8mer) associated with INDELS in HCC
Supp Table S2 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Supplementary Table 2
Supp Table S1 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Supplementary Table 1
Supp Figure S9 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S9 shows frequencies of tumor-infiltrating immune cells in tumors derived from ptgs2-KO and ptges-KO murine BrafV600E melanoma cells
Table S4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Neopeptides (9mer) associated with SNV alterations in HCC
Supp Figure S7 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S7 shows the correlation between PTGES mRNA level and collagen-related genes in a cohort of patients with advanced melanoma
Supp Figure S6 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S6 shows the analysis of collagen mRNA levels in ptgs1-KO, ptgs2-KO, and ptges-KO cell lines in S6A to H; qRT-PCR results in S6I; and Venn diagram showing the common and significant collagen genes in S6J
Table S2 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Somatic mutations, insertions, deletions identified in 40 HCC tumors
Supp Figure S5 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S5 details the conditions of RNA sequencing analyses
Table S12 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

HED results
Table S11 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

HLA divergence score overall and for each HLA type stratified by recurrence and phenotype
Supp Figure S2 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Figure S2 summarizes the calculation details of collagen positivity
Table S1 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Immune staining in HCC tumors
Figure S4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

RNA-seq Immune infiltration stratified by LOH.
Figure S3 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Scatter plot matrix showing the negative correlation between SNV mutations, neoantigen load, and immune infiltration scores.
FIGURE 4 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

Functional differences between celecoxib and CAY10678 and the impact of CAY10678 on tumor growth in mice. A, Release of PGE2 in supernatants in murine BrafV600E melanoma cells (left) and human WM793 cells (right) treated with different concentrations (0, 5, and 10 μmol/L) of celecoxib and CAY10678, measured by ELISA (n = 4). B, Proliferation assay of murine BrafV600E melanoma cells. Cells were treated with different concentrations of celecoxib and CAY10678 (0, 5, and 10 μmol/L). Cell viability was assessed at 0, 24, 48, and 72 hours. Results represent the fold change relative to the OD value of each group prior to treatment (n = 6). Differences between two groups were analyzed by repeated measures one-way ANOVA, followed by Tukey post hoc test. C, Shown are results of qRT-PCR analyses for col3a1, col4a1, col4a2, col8a1, col16a1, and col18a1 genes in murine BrafV600E melanoma cells treated with 0.1% DMSO, 10 μmol/L celecoxib, or 10 μmol/L CAY10678 for 24 hours. Bar graphs show the fold change relative to mRNA levels of control (0.1% DMSO) for each gene (n = 4). D, Left, Tumor volume at indicated timepoints for murine BrafV600E melanoma cells. A total of 1 × 106 cells per mouse were injected subcutaneously into the flanks of C57BL/6J mice. The tumor-bearing mice were randomly assigned into two groups on day 8: vehicle (n = 5) and CAY10678 (n = 7) groups. Mice in the CAY10678 group were treated with intraperitoneal injection of 100 mg/kg CAY10678 daily. D, Right, Tumor volume for individual mice in each treatment group. E, Mice were euthanized on day 21, and the tumors were weighed. F, PGE2 levels in tumors were measured by ELISA. G, Chronologic changes in body weight in the two groups. Graph values represent mean ± SD. Significance in difference between two groups was tested by Student t test. Differences in tumor volume and body weight were analyzed by repeated measures one-way ANOVA followed by Tukey post hoc test. **, P < 0.01; *, P < 0.05. N.S., not statistically significant.
Figure S2 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

The most frequently mutated genes included MADCAM1 (12%), EIF1AX (10%), NF1 (10%), PTPRS (10%), NRAS (8%), TP53 (8%) (A). The majority of mutations were SNVs with a small percentage of deletions and insertions (B). Missense mutations were most common followed by splice site mutations, frameshift deletions and nonsense mutations. The most common DNA substitution types were C>T transitions, followed by T>C transitions, C>A transversions, C>G transversions. The distribution of DNA substitution type per tumor is shown in C.
FIGURE 2 from Inhibition of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition in Melanoma Tumors and May Improve Immunotherapy Efficacy by Reducing T-cell Exhaustion
Authors: Fukuda Yasunari , Kim Sun-Hee , Bustos Matias A. , Cho Sung-Nam , Roszik Jason , Burks Jared K. , Kim Hong , Hoon Dave S.B. , Grimm Elizabeth A. , Ekmekcioglu Suhendan
Published: July 2023

In vivo tumor growth assessment and RNA-seq characterization of murine BrafV600E melanoma cells with ptgs1, ptgs2, or ptges KO. A, Cell proliferation assay in scramble, ptgs1-KO, ptgs2-KO, and ptges-KO murine BrafV600E melanoma cells. Results represent the fold change relative to the OD value of baseline levels at time 0 for each cell (0, 24, 48, and 72 hours after culture; n = 6). Differences between two groups were analyzed by repeated measures one-way ANOVA, followed by Tukey post hoc test. B, Left, Tumor volume measurement at indicated timepoints for scramble, ptgs1-KO, ptgs2-KO, and ptges-KO cells. A total of 1 × 106 cells per mouse were injected subcutaneously into the flanks of C57BL/6J mice: n = 8 mice each for scramble, ptgs1-KO, and ptgs2-KO groups, and n = 7 for ptges-KO group. Differences in tumor volume between two groups were analyzed by repeated measures one-way ANOVA, followed by Tukey post hoc test. B, Right, Tumor volumes for individual mice in each group are shown. C, Tumor-free survival (tumor volume < 1,000 mm3) was estimated using the Kaplan–Meier method and compared using the log-rank test. D, Heat map showing the unsupervised hierarchical clustering of the mRNA levels (Reads Per Kilobase Million [RPKM]) of eight collagen-related genes across scramble, ptgs1-KO, ptgs2-KO, and ptges-KO cells. RNA was extracted from three different subclones in each cell line. E, Spearman correlation values between immune-suppressive markers and collagen-related genes in melanoma samples from TCGA-SKCM dataset. Graph values represent mean ± SD. **, P < 0.01. N.S., not statistically significant.
FIGURE 4 from Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
Authors: Ganly Ian , Kuo Fengshen , Makarov Vladimir , Dong Yiyu , Ghossein Ronald , Xu Bin , Morris Luc G.T. , Chan Timothy A.
Published: July 2023

Differential gene expression of immune infiltration genes of tumors with global LOH compared with tumors without global LOH is shown in A. Gene set enrichment analysis showing pathways significantly altered is shown in B.
Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs
Authors: Dexheimer Thomas S. , Coussens Nathan P. , Silvers Thomas , Wright John , Morris Joel , Doroshow James H. , Teicher Beverly A.
Published: July 2023

Multicellular spheroids comprised of malignant cells, endothelial cells, and mesenchymal stem cells served as an in vitro model of human solid tumors to investigate the potentiation of DNA-damaging drugs by pharmacologic modulation of DNA repair pathways. The DNA-damaging drugs, topotecan, trabectedin, and temozolomide were combined with varied inhibitors of DNA damage response enzymes including PARP (olaparib or talazoparib), ATM (ataxia telangiectasia mutated; AZD-1390), ATR (ataxia telangiectasia and Rad3-related protein; berzosertib or elimusertib), and DNA-PK (DNA-dependent protein kinase; nedisertib or VX-984). A range of clinically achievable concentrations were tested up to the clinical Cmax, if known. Mechanistically, the types of DNA damage induced by temozolomide, topotecan, and trabectedin are distinct, which was apparent from the response of spheroids to combinations with various DNA repair inhibitors. Although most combinations resulted in additive cytotoxicity, synergistic activity was observed for temozolomide combined with PARP inhibitors as well as combinations of the ATM inhibitor AZD-1390 with either topotecan or trabectedin. These findings might provide guidance for the selection of anticancer agent combinations worthy of further investigation.

Significance:

Clinical efficacy of DNA-damaging anticancer drugs can be influenced by the DNA damage response in tumor cells. The potentiation of DNA-damaging drugs by pharmacologic modulation of DNA repair pathways was assessed in multicellular tumor spheroids. Although most combinations demonstrated additive cytotoxicity, synergistic cytotoxicity was observed for several drug combinations.
Does self-concept affect mathematics learning achievement?
Authors: Kania Nia , Juandi Dadang
Published: July 2023

Students who study at home certainly affect their self-concept. Their study found that knowledge of distance learning affects the perceived usefulness of this process. This study described self-concept has an influence on learning achievement in mathematics. The type of research used in this study was descriptive quantitative research to determine the relationship between students’ self-concept and learning achievement in mathematics. This research was conducted in class 8 of State Junior High School (SMPN) 1 Palasah, Indonesia with 151 students as respondents. The self-concept data was obtained from a study questionnaire that had previously estimated its validity and reliability. This analysis is used to explain the data in the form of standard deviation, average, and low score. Self-concept is categorized into three categories (high, medium, and low). Self-concept is categorized into two kinds, namely positive self-concept, and negative self-concept. Categorization of self-concept can also be divided into three kinds. A high self-concept is also called a more positive self-concept, a moderate self-concept is also called a positive self-concept, and a low self-concept is also called a negative self-concept. Therefore, when students have a positive self-concept, it affects learning achievement positively as students needhaveaves to have a self-concept in learning mathematics.
Alternative curriculum model: Mosque-based education integration
Authors: Susilo Mohamad Joko , Kartowagiran Badrun
Published: July 2023

This study developed a mosque-based education integration model curriculum in the face of modernization. This development research adopted the ADDIE development model or analysis, design, development, implementation, and evaluation. This research was conducted in a limited way at the Syuhada Mosque Foundation, Yogyakarta, Indonesia. The informants were 19 people (one foundation administrator, three school principals, and 15 teachers). The research was conducted from January to June 2022. Data collection techniques were carried out through observation, questionnaires, and documentation. The data analysis technique was carried out in a qualitative and descriptive manner. The results of this study are in the form of a mosque-based education integration model curriculum (IPBM), also known as the Syuhada curriculum, with the characteristics of syuhada attached to this curriculum. The urgency and contribution of this research are to assist educational units in developing a curriculum that coincides with the policy of changing the 2013 curriculum to become an independent curriculum. In addition, to support the implementation of an independent curriculum, develop and design an operational curriculum that is unique to educational units.
Audio-visual-based history learning media materials about human life in the literary age
Authors: Insani Marzius , Haenilah Een Yayah , Hariri Hasan , Sinaga Risma Margaretha
Published: July 2023

This study aims to develop and test the feasibility of audio-visual-based learning media in history learning class X in senior high school. This study is a research and development (RD) type with the analyze, design, development, implementation, evaluation (ADDIE) model. The research involved 96 students of class X IPS or social science at State Senior High School 1 Bandar Lampung, Indonesia. The data collection techniques as well as the instruments employed questionnaires, observation, interviews, and documentation. Data analysis techniques employed qualitative and quantitative analysis. The results of the study show that: i) The development of audio-visual-based learning media on material about human life in Indonesia’s literacy period was made using the Adobe Photoshop application; and ii) The feasibility of the validation results of media experts, material experts, and learning experts (history teachers) successively with an average result of 4.73 (very good), 4.28 (very good), 4.50 (very good) and the results of the assessment students at 4.37 (very good). Then, the audio-visual-based learning media is declared feasible to use. This audio-visual-based historical learning media has its charm in being able to encourage students to become higher in learning history.
Perception of distance learning among undergraduate medical students during COVID-19 pandemic
Authors: Sari Desy Nofita , Asri Rizkia Chairani , Fadila Zurraya
Published: July 2023

In response to the newly emerging coronavirus disease or COVID-19 pandemic and its profound consequences on the world, many changes have been made to medical education. It includes teaching and learning methods that ensure the educational process’s success. The Andalas University Faculty of Medicine, Indonesia had to implement new online teaching strategies. This study examined how medical students perceived online education during the COVID-19 outbreak. The study is cross-sectional, employed online questionnaires. The response was that most students prefer face-to-face learning in practicum and clinical skills, which require hands-on methods to improve student skills. Half the students were satisfied, and several were neutral about distance learning. The student who agrees that the lecturer is active and has the expertise and knowledge for the class is more satisfied with distance learning (p0.001). The student who agrees about the platform quality, understandable learning guide, and facility from faculty has a higher level of satisfaction with distance learning (p0.001). This study concluded that a medical student at the Andalas University Faculty of Medicine was mainly satisfied with the institution’s response to the pandemic. However, medical faculty must evaluate and improve the quality of education in online learning.
Culture in early childhood education: Insights into Saudi preschool teaching
Authors: Alghamdi Ahlam Abdullah
Published: July 2023

Culture is constructed by society and in turn constructs the identity of a people. The patterns of behaviors, practices, and values shared by a group of people represent and reflect their ethnic, religious, and gender orientations. Knowledge about people’s cultural backgrounds contributes to our understanding of the role of education in shaping past, present, and future generations. Therefore, this study explores preschool teachers’ cultural views regarding the teaching of young children in a Saudi early childhood education setting. A phenomenological qualitative research approach is used in this study. Data are collected through semistructured focus group interviews with 10 preschool teachers who teach young children in public preschools located in the western region of Saudi Arabia. The thematic analysis of the qualitative data reveals two main themes in the teachers’ narratives: i) Religion-based instruction; and ii) Gender-related issues. The participants in this study reported engaging in a set of practices that showed how their cultural identities, including their nationality, gender, religious beliefs, and history, influenced their roles as educators. Within the rich cultural context of Saudi culture, the teachers reported being strongly committed to their social and spiritual values when teaching young children.
Implicit Bias in Health Care Providers During Providing Health Care Ser-vices to Patients in A Tertiary Care Hospital South Punjab Pakistan
Authors: Leghari Shazia Yasmeen , Perveen Tahira , Nazar Kalsoom
Published: July 2023

Introduction: Bias means an unreasoned and unfair distortion of judgment in favour of or against a person or thing. It is the evaluation of something or someone that can be positive or negative, and implicit or unconscious bias is when the person is unaware of their evaluation. Unconscious or implicit bias describes associations or attitudes that reflexively alter our perceptions, there by affecting behaviour, interaction, and decision-making Methods: This study qualitative cross-sectional study design is used. Implicit Assessment Tool (IAT) used to assess the age Implicit, Religion Implicit and Skin tone Implicit among nurses. The data was analysed by SPSS version-18 & Microsoft Excel.  Out of 100 respondent 23% showed a strong automatic preference for light skin compared to dark skin people in Skin-tone IAT. Results: Out 0f 100 just 2% showed strong automatic preference for dark skin as compared to light skin people. During the Religion IAT out of 100 respondents just 1% nurses showed a strong preference for Judaism compared to Islam. 96.0% showed strong automatic preferences for Islam compared to Judaism. 29 % respondents showed a strong automatic preference for Islam compared to Christianity. While 2% participants showed a strong preference for Christianity compared to Islam. In Age implicit assessment test 30% nurses showed strong automatic preference for young people to old people. Just 1 % nurses showed strong automatic preference for old people compared to young people. 30 % nurses showed moderate level of automatic preferences for young people as compared to old people, while just 2 % have moderate automatic preference for old people as compared to young people. Conclusion: This study concluded that Nurses have a strong automatic preference towards their own religion so that they prefer Muslim patients unconsciously rather than the other religion. This study also reveal that during giving care nurses have strong automatic preference to young people and light skinned people as compared to dark skinned and old people.
Factors Affecting Academic Performance of BS Food Technology Students
Authors: Gamboa Marielle D.
Published: July 2023

The study aims to evaluate the factors affecting the academic performance of Bachelor of Science in Food Technology (BSFT) students of Bulacan Agricultural State College. Purposive sampling was used in the study wherein all BSFT students were instructed to answer a survey disseminated through social media platforms. The instrument comprises questions to obtain program selection information during admission test and a 5-point Likert scale (5-definitely true to me; 4-true to me; 3-uncertain; 2-not true to me; 1-definitely not true to me) to rate the given factors. Six factors were evaluated in this study which includes the course, study habit, learning style, motivation, teacher, and social factors. Results showed that the majority of students are positive in their academic performance. Students appear to be confident in their study habits. The BSFT students agree that the professors have demonstrated professional, ethical, and moral attitudes toward them.  Results also showed that BSFT students express more compassion in their studies than in their social life. It is recommended that activities to improve the engagement of students in the program should be created. This could be done through immersion in some of the actual work of food technology professionals e.g. research and community involvement. Realizing their contribution to society may improve their perception of the course and enhance their study habits toward better academic performance.
To Paint a New Picture: Into the Lives of Eldest Siblings of Separated Fami-lies during COVID-19
Authors: Rabuya Daniel Andrei , Moralde Franz Elloise , Villacampa Angel Rose , Sagosa Shane , Fernandez Ravyn Bridget , Cabrera Ralley Kyle , Cagalitan Willem Mikkel , Bendibel Rycel Monique , Del Socorro Celeste , Gagani Flordeliza
Published: July 2023

This study emerged to enable humanitarian organizations to provide better services for children in separated families by understanding eldest siblings' lived experiences. Through Husserlian’s descriptive phenomenology utilizing Colaizzi’s method of data analysis, six participants were interviewed online at the height of the pandemic in 2021-2022 in Cebu City, Philippines. Data were transcribed using data reduction methods and revealed 6 themes: (1) "Having to always be the bigger person": Role Intensification; (2)"Devoting myself to things that weren't supposed to land on me": Adult Difficulties; (3) "Becoming stronger and keeping a soft spot"; Growing in Stature; (4) "True brothers are there for you”: The Support Given to the Supporter; (5) “To be free but mindful:'' Motivation to Persevere; (6) “To paint a better picture of life: ''Setting and Living an Example. The researchers discovered that the eldest siblings were forced to take charge of responsibilities that were not supposed to be theirs; encountered emotional difficulties such as loneliness and anxiety in facing a wide range of familial, developmental, and logistical problems; coped through these challenges with social support, religious devotion, and modern entertainment; and devoted their lives to protecting their siblings and giving them the lives they deserve. From these results, the researchers recommend that counseling is provided for the eldest siblings to enable the development of support structures and meaningful relationships that propel the eldest siblings to persevere.
Dimensions of Ethical Accounting Practices among Certified Public Accountants: An Exploratory Factor Analysis
Authors: Niniel Jaylou C. , Sucuahi William T.
Published: July 2023

This research study explored and established the dimensions representing ethical accounting practices among Certified Public Accountants. The respondents were Certified Public Accountants from different sectors of the profession in Davao del Norte, of legal age and with at least two years of experience in accounting who were chosen through stratified random sampling. Responses from the Key Informant Interview were analyzed and the item statements were then used as initial statement pool for the survey. Kaiser-Meyer-Olkin (KMO) index for sampling adequacy, Bartlett’s test of sphericity for testing the multidimensionality, principal component analysis for data reduction, and VARIMAX for rotation. Thirty-one (31) original items were surveyed and processed through exploratory factor analysis and only twenty-six (26) items of ethical accounting practices passed the ≥.40 threshold after ten iterations which loaded to eight dimensions. The identified eight generated dimensions of ethical accounting practices were moral philosophies, personal values and principles, religiosity, objectivity, reliance to authority, integrity, professional behavior and public_welfare.
Teaching Outside the Box: Senior High School Teaching Experiences, Challenges, and Windows of Innovations of Non-Social Science Majors
Authors: Branzuela Marco J. , Ayro Eufemia C. , Cruz-Vidal Michaela Jennarine DL.
Published: July 2023

This research examines the experiences of non-social science majors teaching in teaching social science subjects in senior high school. It utilized a mixed-method approach. A survey and an interview were utilized to collect the data. Sixty respondents took the survey to identify their teaching experiences. Five out-of-field social science teachers who were severely challenged were invited to an interview. Results revealed that more female teachers were engaged in out-of-field teaching. Moreover, teachers aged 26-30 are more likely to be assigned to out-of-field teaching. Also, both public and private schools experience the challenge of out-of-field teaching. Most of the teachers engaged in this scenario were non-education graduates. Core subjects under social sciences are the common subjects taught by non-social science majors. The survey reveals the experiences of non-social science majors in their mastery of the subject handled, ability to prepare scholarly learning material, classroom pedagogy/classroom activity, and psychosocial guidance to students for college preparations.  It is discovered that non-social science majors always adhere to the challenges posed by out-of-field teaching. However, psychosocial guidance to students for college preparation was the domain that makes it challenging for non-social science majors to overcome. Five themes emerged based on this study; out-of-field teaching experiences, challenges of non-social science majors, coping mechanisms employed by non-social science majors, perception of non-social majors, and roles of school administrators. The COPE approach was devised to aid teachers, school administrators, and the Department of Education to mitigate the challenges posed by out-of-field teaching experiences.
Analysis of the Influence of Capital Market Level, Mindset, and Minimum Capital on Investment Interest of Bangka Belitung University Students with Investment Risk as Moderating Variable
Authors: Berthalia Fifi , Mareta Nela , Amanda Lola , Julia
Published: July 2023

This study aims to determine whether there is an influence on the level of capital market knowledge, mindset, and minimal capital with investment risk as a moderating variable. This research was conducted at the Faculty of Economics, Bangka Belitung University. The method in the research used is the quantitative method from the primary data. Data collection using the questionnaire method is in the form of respondents' answer results expressed in the form of numbers from questionnaires measured using the Likert scale. The results in this study are that the level of knowledge of the capital market, mindset and minimal capital have a significant positive effect on students' investment interests, while the relationship between investment risks is able to moderate the variable level of knowledge and minimal capital to the influence of student investment interests. The relationship of investment risk is not able to moderate the mindset variables to the influence of students' investment interests. In this study, it was shown that there were 55,7% influence and the remaining 44,3% influenced by other factors.
Knowledge, Attitude, and Practices of English Teachers in Utilizing Integrative Performance Tasks in English
Authors: Aquino Khate Giselle G , Rufino Mark Clester A , Paguirigan Elgin S , Cruz-Vidal Michaela Jennarine DL
Published: July 2023

The study “Knowledge, Attitude and Practices of English Teachers in Utilizing Integrative Performance Tasks in English” described and then analyzed the knowledge, attitude and practices of English teachers in designing and utilizing Integrative Performance Task in the New Normal Education. To achieve this aim, the researcher used a sample of 50 English Senior and Junior High School public school teachers in Talavera, Nueva Ecija. The researcher used the descriptive-correlational method of research, which utilized a researcher-made questionnaire to gather the data needed for the study. The findings showed that the majority of the teacher-respondents of Junior and Senior High Schools of Talavera, Nueva Ecija are Teacher III with previously earned units in Master's Degree who are handling Grade 10 students. Additionally, most of them are female, single, and between the ages of 23 and 29. Furthermore, the result shows that there was no significant relationship found between the profile of the respondents and their knowledge, attitude, and practices in using integrative performance tasks. Moreover, it showed that the teacher-respondents’ Highest Educational Attainment and Grade Level Taught significantly correlated with their Individual Performance Commitment and Review (IPCR) ratings. Lastly, it was found to have no significant relationship between the teachers’ utilization of Integrative Performance Task (IPT) in terms of their knowledge, attitude, and practices and their Individual Performance Commitment and Review (IPCR) ratings. Conclusions were drawn based on the findings of the study and recommendations were presented and offered.
Understanding Stakeholders’ Perspective on An Innovative Business Model for Pediatric Immunization Records: A Single Case Study
Authors: Ramos-Siman Elaine C. , Orencia Abrian Joy B.
Published: July 2023

The purpose of this qualitative case study is to explore the potential value of an innovative business model on pediatric immunization record management which will serve as the basis for the development of a digital platform for the use of pediatric consultants and medical secretaries at a private secondary hospital in Quezon City.  The study utilized a qualitative case study involving the pediatric consultants and medical secretaries of a private secondary hospital in Quezon City.  Qualitative data for this study were gathered through in-depth, semi-structured interviews, focus group discussions, documents, journaling, and observations. Results have shown that pediatric consultants and medical secretaries follow only one way of arranging patients' records which is through alphabetical order using the surname. Many clinics and hospitals still rely on paper-based medical records to document patients' information. All participants shared the same difficulties and sentiments when it comes to the problems they have in the current way they deal with immunization records.  Based from the statements of the participants, results revealed that pediatric consultants and medical secretaries support and are in favor of the use of a web-based record management system.  However, some participants stated their apprehensions for the security of patient information.  Further study that focuses on formal training is recommended to increase the confidence of the healthcare workers in utilizing digital record management systems and intense exploration of the potential challenges in adapting a digitized records management system must be conducted.
Aligning the Ship Engine Cadets’ Skills to the 21st Century
Authors: Tabora Brando T
Published: July 2023

The Philippines is one of the single largest nationality groups in the maritime and shipping sectors; as a result, the nation's efforts to modernize the skills of the engine cadets are significant. This study aimed to assess the engine cadets' skill level in relation to the requisite 21st-century skills while they were receiving shipboard training at TORM Shipping Philippines Inc. It used a sequential explanatory mixed-methods design. The paper used mean, standard deviation, and Mann-Whitney for comparing differences between two independent groups for the statistical treatment analyses of the quantitative data. Thematic analysis of the descriptive data provided by the interviewees involved coding and identifying common themes, patterns, and responses. The findings revealed that the engine cadets were competent in three (3) areas but needed to be more competent in the remaining area (inventive thinking). This signified that the engine cadets need supplemental training in the areas where they are less apt to improve their skills in all variables, especially 21st-century skills. The management of maritime schools and policymakers must address the common factors that prevent engine cadets from acquiring 21st-century skills, according to the study.
Child Rearing Styles of Queer Parents in Relation to Child Adjustments
Authors: Fernandez Christine Joy L. , Ayro Eufemia C. , Mamaclay Ali G. , Cruz-Vidal Michaela Jennarine DL. , Pangan Emmanuel John R.
Published: July 2023

This study focused on determining the child rearing styles of queer parents about child adjustment. The case study was used to determine the unique experiences of the subject participants. Eight queer parents and eight children of queer parents participated in the study. Further, the researcher used unstructured interviews in collecting the research data. The results revealed that most of the queer parents belonged within the age range of more than 40, gay men and lesbian women, unmarried and living with no partner, Roman Catholic, Ilokano and Tagalog, college graduate, self-employed with a monthly family income of 20,001 – 30,000, and with one child. Moreover, most of the male and female child participants were under 17, first-born child with one sibling belonged to household members of three, nephews of queer parents and lived with their non-biological parents for more than 14 years. There is an emerging theme derived from the experiences of queer parents, such as their experiences in various aspects of parenthood. The queer parents’ child rearing styles were lax parenting style and disciplinarian style. Two emerging themes derived from the participants' experiences, such as their lived experiences consisting of three sub-themes: being raised by non-biological parents, being bullied and having conflict with parents. Similarly, two sub-themes were derived from the theme description of the present life, such as comfortable life and crossing to life challenges. The child adjustment that emerged was psychosocial. The emerging well-being of the child participants was life contentment. The emerging sub-themes under the description of parents’ way of rearing a child were composed of imposition of discipline, provision of basic needs and inculcation of the value of education. The child participants were appreciative and satisfied with the kind of life they had. Since most of the parents were single, the government through the local government units may properly disseminate the Solo Parent Act as to benefits and privileges under the law through series of orientation and assist the queer parents to have their Solo Parents card. Non-government organization, civic organization and the church may conduct series of guidance and counselling, psychological intervention and spiritual nurturing programs and activities to enhance the quality of life among child of the queer parents.
Teachers’ Readiness and Supportive Environment Toward Better Research Productivity and Skills: Basis for a Policy Development on Research Program
Authors: UY Cristeta S. , Callo Eden C.
Published: July 2023

The main problem of the study was to develop a standard school support program to enhance the implemented basic research program at San Jose National High School. Specifically, the determine the teachers’ level of readiness in research, the extent do the School Factors affect the teachers’ participation in research, the extent is the perceived supportive environment affect the level of research competency of teachers, Level of Competency of teachers in conducting research, the perceived level of Research Writing skills of the teachers. It identified the relationship between the teachers’ level of competency in research and the perceived level of the teachers’ readiness to conduct research and the effect of school factors, the relationship between the extent of school factors affecting participation in the conduct of research and challenges in conducting research, level of research productivity, and level of research skills and whether the perceived level of supportive environment significantly mediate the relationship between teacher’s level of readiness and the level of research productivity and level of research skills. The study was descriptive with a researcher-made questionnaire as the instrument of the study. The questionnaire was administered to 661 teachers in the Division of San Pablo City for school year 2022-2023. The data collected were treated using mean scores, standard deviation, Pearson product moment correlation, simple regression, and multiple regression analysis. Results show following findings: the teachers are all well equipped with the desired readiness needed to conduct research studies; school-related factors are very important in influencing teachers' engagement in research investigations; teacher's ability to do research projects is greatly influenced by their cognitive ability, the school's support and assistance, the principal's leadership skills, and the research culture at their institution; the teachers were all well-versed in each of the parts of a research paper; the teachers’ research skills is significantly related to the teachers’ readiness to conduct research and the effect of school factors; the relationship between effect of school factors in research engagement and challenges in conducting research is significant as well as with research productivity and research skills; and the supportive environment significantly mediate the relationship between the teachers’ level of research readiness and level of teachers’ research skills but does not significantly mediate the teachers’ level of research readiness and level of their research productivity. Strategic planning and support from the school through the developed standard school support program is encouraged.