bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient evaluation of a smartphone application for telehealth care of opioid use disorder
Authors: Bosse Jordon D. , Hoffman Kim , Wiest Katharina , Todd Korthuis P. , Petluri Ritwika , Pertl Kellie , Martin Stephen A.
Published: September 2022

Background

People with opioid use disorder (OUD) face barriers to entering and remaining in life-saving treatment (e.g., stigma, detrimental interactions with health care, and privacy concerns). Telehealth and related technology can reduce barriers to entering and staying in care. Patient feedback is critical to the development of these newer treatment approaches to ensure they are usable and do not inadvertently recreate treatment barriers.

Purpose

Evaluate the perceived usability of existing and planned features of a mobile application (app) that facilitates delivery of OUD treatment via telehealth.

Methods

People with current or prior experience with OUD treatment were eligible for the study. Participants (n = 31; 55% women) provided feedback on an interactive prototype demonstration via individual qualitative interviews and completed a quantitative survey on the app’s perceived usability. Descriptive statistics summarized the usability survey. We analyzed qualitative interview transcripts to elicit common themes.

Results

Participants were primarily white (77%) with a mean age of 42.2 years (range 22–69). Participants rated the six major features of the current app as helpful (median response 5 out of 5) and appreciated the flexibility of conducting a visit from a place of their choosing. Participants regarded the five proposed components of the app, such as daily affirmations and medication treatment-related reminders (e.g., pick up medication at pharmacy, medication schedule), as useful features with medians 5 out of 5, and reported they would recommend the app to others for OUD care. Participant qualitative interviews provided additional information on perceived usability of existing and proposed app features.

Conclusion

Our study suggests that an appealing, easy-to-use app—with tools and features that effectively support care—could circumvent existing barriers and foster sustained recovery.
Association of novel MUC16, MAP3K15 and ABCA1 mutation with giant congenital melanocytic nevus
Authors: Zhou Renpeng , Wang Qirui , Hou Jialin , Wang Danru , Liang Yimin
Published: September 2022

Background

Giant congenital melanocytic nevus (GCMN) is the benign nevomelanocytic proliferation. Mutations in NRAS have been previously detected in GCMN, but mutations in BRAF are generally lacking in the Chinese population. Mutated genes in this disease can estimate the risk of malignant transformation in GCMN. Therefore, it is worth investigating the genetic information of GCMN.

Methods

Here, we presented two cases of GCMN of the upper extremities. The clinical and histological data were analyzed. The whole exome sequencing (WES) was performed to investigate the mutational profile of peripheral venous blood (PB), normal skin (NS), small melanocytic nevus (SMN), deep penetrating and non-penetrating GCMN (dPGCMN and nPGCMN).

Results

We showed a reduction in the circumference of involved upper extremities in both patients. The clinical and histopathological data indicated the reduction of adipose tissue associated with the invasion of GCMN. The WES data revealed that MUC16, MAP3K15 and ABCA1 were novel potential candidate genes for the disease as well as biomarkers for predicting malignant transformation.

Conclusion

The MUC16, MAP3K15 and ABCA1 may serve as novel biomarkers for predicting malignant transformation and targets for the diagnoses and therapy for the GCMN.
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial
Authors: DiSilvestro Paul , Banerjee Susana , Colombo Nicoletta , Scambia Giovanni , Kim Byoung-Gie , Oaknin Ana , Friedlander Michael , Lisyanskaya Alla , Floquet Anne , Leary Alexandra , Sonke Gabe S. , Gourley Charlie , Oza Amit , González-Martín Antonio , Aghajanian Carol , Bradley William , Mathews Cara , Liu Joyce , McNamara John , Lowe Elizabeth S. , Ah-See Mei-Lin , Moore Kathleen N. ,   on behalf of the SOLO1 Investigators
Published: September 2022

PURPOSE

In SOLO1/GOG 3004 (ClinicalTrials.gov identifier: NCT01844986 ), maintenance therapy with the poly(ADP-ribose) polymerase inhibitor olaparib provided a sustained progression-free survival benefit in patients with newly diagnosed advanced ovarian cancer and a BRCA1 and/or BRCA2 (BRCA) mutation. We report overall survival (OS) after a 7-year follow-up, a clinically relevant time point and the longest follow-up for any poly(ADP-ribose) polymerase inhibitor in the first-line setting.

METHODS

This double-blind phase III trial randomly assigned patients with newly diagnosed advanced ovarian cancer and a BRCA mutation in clinical response to platinum-based chemotherapy to maintenance olaparib (n = 260) or placebo (n = 131) for up to 2 years. A prespecified descriptive analysis of OS, a secondary end point, was conducted after a 7-year follow-up.

RESULTS

The median duration of treatment was 24.6 months with olaparib and 13.9 months with placebo, and the median follow-up was 88.9 and 87.4 months, respectively. The hazard ratio for OS was 0.55 (95% CI, 0.40 to 0.76; P = .0004 [ P < .0001 required to declare statistical significance]). At 7 years, 67.0% of olaparib patients versus 46.5% of placebo patients were alive, and 45.3% versus 20.6%, respectively, were alive and had not received a first subsequent treatment (Kaplan-Meier estimates). The incidence of myelodysplastic syndrome and acute myeloid leukemia remained low, and new primary malignancies remained balanced between treatment groups.

CONCLUSION

Results indicate a clinically meaningful, albeit not statistically significant according to prespecified criteria, improvement in OS with maintenance olaparib in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation and support the use of maintenance olaparib to achieve long-term remission in this setting; the potential for cure may also be enhanced. No new safety signals were observed during long-term follow-up.
Introduction
Authors: Asif Manan Ahmed
Published: September 2022

In situating the questions of how languages shape the ideas of history, history writing, and self-identification of community, the importance of colonialism is key. Allison Busch's scholarship framed an important intervention in our collective approach to the early-modern subcontinent. This article introduces a special section consisting of articles by students, colleagues, and mentors of Busch.
The Transcultural Eros of the ManchesterCāndāyana
Authors: Aitken Molly Emma , Busch Allison
Published: September 2022

This essay explores a single illustrated manuscript of Maulana Daud's Sufi narrative the Cāndāyana from the Rylands Library, Manchester, to help make sense of how Sufi poets and the sultanate-period painters who illustrated their verses realized the indigenous aesthetics of eros and the nāyikā.
Attempted Iconoclasm
Authors: Ollett Andrew
Published: September 2022

Dhanapāla's hymn to the image of Mahāvīra at Sanchore, composed in Apabhramsha around the beginning of the eleventh century, has been recognized to contain the earliest reference in an Indian language to Maḥmūd of Ghazna's raids in northwestern India in 1024, culminating in his destruction of the temple of Shiva at Somnath, in Gujarat. This hymn has been read as referring to another act of iconoclasm—or rather attempted iconoclasm, since it was ultimately unsuccessful—by Maḥmūd of Ghazna. This article shows that the attempted iconoclasm in question is not Maḥmūd's, but rather that of an earlier king. These earlier events, together with the geography of conquest and pilgrimage provided by Dhanapāla, suggest a political subtext for the hymn; namely, a veiled critique of the inability of the Cauḷukya kings of Gujarat to protect the religious landscape, and a veiled praise of Dhanapāla's friend and patron, the Paramāra king Bhōja.
Defining a Tradition
Authors: Rajpurohit Dalpat Singh
Published: September 2022

Allison Busch's seminal work on the classical Hindi literature of Mughal India demonstrated how the composition of works of poetic theory (ritigranths) became a defining literary enterprise of vernacular court poets in the Mughal-Rajput milieu. Though firmly based in a Sanskrit worldview, Hindi intellectuals exhibited newness in their theorization of the art of poetic craft. Engaging with Busch's work on the ritigranth genre, this article demonstrates how the poet-scholars of Rajasthan who were experts in Brajbhasha and Marwari—or Hindi and Rajasthani, respectively, as they are largely understood today—theorized and created new knowledge systems to define their four-hundred-year-old Marwari literary culture. Keeping up with the theoreticians of Brajbhasha who blended Vaishnava bhakti (devotion) with poetic theory, the Rajasthani scholars placed their work in a multilingual literary culture that was increasingly expanding as India came under the knowledge regimes of colonialism.
“Our 1789”
Authors: George Nathaniel
Published: September 2022

Were the events of 1975–77 in Lebanon, commonly thought of today as an internecine sectarian war between Christians and Muslims, more comparable to the furies of revolution and counterrevolution? This article reframes the Lebanese National Movement's (LNM) “Transitional Program” as a revolutionary, anti-colonial, and radical republican challenge that sought to implement a new constitutional order based on popular sovereignty. Internally, it severed the link between sectarian affiliation and political representation that was the hallmark of the Lebanese regime. Externally, the program announced a commitment to popular struggle against imperially sustained settler colonialism in Palestine while calling into question the authoritarian practices of most regional regimes. Drawing from periodicals, memoirs, diplomatic sources, and interviews, this article considers the efforts of the LNM-PLO alliance to push the Transitional Program in the political sphere and on the battlefield. In turn, it demonstrates how the United States, Syria, Israel, and Lebanese counterrevolutionaries worked in concert to ensure that the sectarian regime would be preserved at the moment of its greatest challenge. Against a historiography that either dismisses the venture as predestined to fail or considers the period only within the shackles of post-defeat melancholia, it reevaluates the history of one of the most explicit emancipatory challenges to the Arab order.
Moving Past Models
Authors: Bardawil Fadi A.
Published: September 2022

This essay makes the case for moving away from a genre of writing about revolutions that elevates particular ones to the status of models and exemplars, which then become the touchstone of all subsequent revolutionary processes. This way of looking at emancipatory movements risks excising some from the domain of revolutionary practice for not fitting a model, and relegating others to the status of belated and derivative ones that repeat the stages of the earlier model. Instead, the author suggests moving past models to pay attention to the practices of translation that revolutionaries engage in and that inform their intellectual and political traditions. Sidelining the conceptual universe of models and centering translation enables a reckoning with difference and the emergence of newness. It is also crucial for rethinking a politics of solidarity across difference in, and for, our present.
Long-Term Outcomes of Bilateral Subthalamic Nucleus Deep Brain Stimulation for Patients With Parkinson's Disease: 10 Years and Beyond
Authors: Park Hye Ran , Im Hyung-Jun , Park Jeongbin , Yoon Byung Woo , Lim Yong Hoon , Song Eun Jin , Kim Kyung Ran , Lee Jae Meen , Park Kawngwoo , Park Kwang Hyon , Park Hyun Joo , Shin Jung-Hwan , Woo Kyung Ah , Lee Jee Young , Park Suyeon , Kim Han-Joon , Jeon Beomseok , Paek Sun Ha
Published: September 2022

BACKGROUND:

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) represents an effective treatment for severe Parkinson's disease (PD), but little is known about the long-term benefit.

OBJECTIVE:

To investigate the survival rate and long-term outcome of DBS.

METHODS:

We investigated all 81 patients including 37 males and 44 females who underwent bilateral STN DBS from March 2005 to March 2008 at a single institution. The current survival status of the patients was investigated. Preoperative and postoperative follow-up assessments were analyzed.

RESULTS:

The mean age at the time of surgery was 62 (range 27-82) years, and the median clinical follow-up duration was 145 months. Thirty-five patients (43%) died during the follow-up period. The mean duration from DBS surgery to death was 110.46 ± 40.8 (range 0-155) months. The cumulative survival rate is as follows: 98.8 ± 1.2% (1 year), 95.1 ± 2.4% (5 years), and 79.0 ± 4.5% (10 years). Of the 81 patients, 33 (40%) were ambulatory up to more than 11 years. The Unified Parkinson's Disease Rating Scale (UPDRS) score was significantly improved until 5 years after surgery although it showed a tendency to increase again after 10 years. The patient group with both electrodes located within the STN showed a higher rate of survival and maintained ambulation.

CONCLUSION:

STN DBS is a safe and effective treatment for patients with advanced PD. This study based on the long-term follow-up of large patient populations can be used to elucidate the long-term fate of patients who underwent bilateral STN DBS for PD.
Viral species differentially influence macronutrient preferences based on honey bee genotype
Authors: Penn Hannah J. , Simone-Finstrom Michael D. , de Guzman Lilia I. , Tokarz Philip G. , Dickens Rachel
Published: September 2022

Food quantity and macronutrients contribute to honey bee health and colony survival by mediating immune responses. We determined if this held true for bees injected with chronic bee paralysis virus (CBPV) and deformed wing virus (DWV), two common honey bee ssRNA viruses. Pollen-substitute diet and syrup consumption rates and macronutrient preferences of two Varroa-resistant stocks (Pol-Line and Russian bees) were compared to Varroa-susceptible Italian bees. Bee stocks varied in consumption, where Italian bees consumed more than Pol-Line and Russian bees. However, the protein: lipid (P:L) ratios of diet consumed by the Italian and Russian bees was greater than that of the Pol-Line bees. Treatment had different effects on consumption based on the virus injected. CBPV was positively correlated with syrup consumption, while DWV was not correlated with consumption. P:L ratios of consumed diet were significantly impacted by the interaction of bee stock and treatment, with the trends differing between CBPV and DWV. Variation in macronutrient preferences based on viral species may indicate differences in energetic costs associated with immune responses to infections impacting different systems. Further, virus species interacted with bee genotype, indicating different mechanisms of viral resistance or tolerance among honey bee genotypes.
Ultrasound-Guided Hydrodissection Provides Complete Symptom Resolution in Radial Tunnel Syndrome: A Case Series and Scoping Review on Hydrodissection for Radial Nerve Pathology
Authors: Gill Benjamin , Rahman Rafid , Khadavi Michael
Published: September 2022

This study analyzes the effectiveness of ultrasound-guided hydrodissection (HD) perineural as a treatment for radial tunnel syndrome (RTS). A literature search was performed along with retrospective analysis of local cases to assess outcomes and safety of this procedure. In the case series, surgical candidates, defined as cases with over 80% but temporary relief after diagnostic injection, were treated with ultrasound-guided HD. Of 22 patients who received ultrasound-guided diagnostic injections, 11 proceeded to HD. All HD patients experienced complete and lasting symptom resolution for a minimum of 2 years, and none required surgery. Thorough literature review provided seven studies, which fulfilled inclusion criteria. Sixty-one patients are represented in the literature. All studies reported significant benefit to pain symptoms with HD of radial nerve, with five specifying over 90% improvement. No adverse effects from HD were noted in any study. Ultrasound-guided HD of the radial tunnel has potential to be a surgery sparing treatment for RTS.
Prone Lachman with Ultrasound: A Literature Review and Description of the Technique
Authors: Raja Altamash E. , Meyer Ryan , Tunis Brandon G. , Moreland Michael L. , Tunis Justin G.
Published: September 2022

Magnetic resonance imaging is the current gold standard imaging modality for diagnosing anterior cruciate ligament (ACL) tears. However, ultrasound has grown in popularity for detecting ACL injuries because of its low cost, portability, and dynamic assessment capabilities. Recent studies demonstrate high sensitivity and specificity for diagnosing isolated ACL tears via ultrasound, but tremendous heterogeneity remains for optimal technique including patient positioning, transducer placement, and dynamic versus static ultrasound usage. As ultrasound becomes ubiquitous in clinics, training rooms, and on the sidelines, identifying objective and sensitive measurements to appropriately screen athletes for significant knee injuries is imperative. This article aims to review the current role of diagnostic ultrasound in ACL injuries and propose a standardized version of the Prone Lachman with Ultrasound test, which is an objective, reliable, and easily reproducible technique to evaluate ACL competency. Developing a standardized protocol will expand the use of point-of-care ultrasound, which may reduce cost and improve efficiency in care.
Accessory articulation of cervical vertebral transverse process: a rare case
Authors: Aslam Sarmad , Aslam Iqrah , Tsang Jeffrey , Latief Farris , Thatuskar Adarsh , Rojed Naveen
Published: September 2022

There are several anatomical variants of the cervical vertebrae described in literature ranging from benign findings to those with varying clinical implications, including association with congenital diseases. We describe a case of an extremely rare anatomical variant of the cervical spine consisting of an accessory articulation of the cervical vertebrae C4 and C5 right transverse processes. The case is of a 35-year-old female who presented to primary care with 6-week history of intermittent, dull neck pain. An X-ray of the cervical spine was obtained which did not demonstrate radiological evidence of an acute fracture, dislocation, nor vertebral collapse. However, the X-ray revealed subtle multilevel anterior marginal osteophytic lipping. As a minor fragmented fracture or osteophytic growth could not be excluded; the patient proceeded to have a CT of the cervical spine. This revealed an accessory articulation of both the C4 and C5 right transverse processes, an extremely rare anatomical variant. Our comparison of both X-ray and CT imaging modality results highlighted the importance of utilising CT in identification in the accessory articulation anomaly, which aids in directing patient to appropriate care. Although similar cases may have been seen in clinical practice, to our knowledge, there are no previously documented C4-5 accessory articulations in the literature.
Διπλωματικές σχέσεις της Ρωμαϊκής και της Περσικής αυτοκρατορίας μέσα από τις πηγές και το αρχαιολογικό υλικό από το 224 μ.Χ έως το 284 μ.Χ.
Authors: Λέκκας Σωτήριος
Published: September 2022

Η διατριβή ασχολείται με τις διπλωματικές σχέσεις που ανέπτυξε η Ρωμαϊκή αυτοκρατορία με τη Περσική κατά το διάστημα 224 μ.Χ ως και το 284 μ.Χ, μέσα από τις πηγές και τα αρχαιολογικά ευρήματα. Παρόλα αυτά, εξετάζονται και οι διπλωματικές σχέσεις της Ρωμαϊκής αυτοκρατορίας με τη Παρθική, αλλά και η πολιτικοστρατιωτική ιστορία του κράτους της Παλμύρας και οι σχέσεις που αυτό ανέπτυξε με τη Ρώμη και τη Περσία. Οι διπλωματικές σχέσεις της Ρώμης με την Παρθία, αλλά κι αυτές της Παλμύρας με τη Ρώμη και τη Περσία συμπεριλήφθηκαν, γιατί επηρέασαν σε μεγάλο βαθμό τις επαφές της αιώνιας πόλης με τη Σασσανιδική Περσία. Στο πρώτο μέρος εξετάζονται οι διπλωματικές σχέσεις της Ρώμης με τη Παρθική αυτοκρατορία από την αρχή τους ως και το τέλος τους. Η αρχή των μεταξύ τους σχέσεων έλαβε χώρα στις αρχές του 1ου αιώνα π.Χ, όταν και συναντήθηκαν πλησίον του Ευφράτη ο Ρωμαίος στρατηγός Σύλλας και ο πρεσβευτής του Πάρθου βασιλιά, ο Ορόβαζος, και η τελευταία διπλωματική επαφή τους συνήφθη το 217 μ.Χ, όταν ο Αρτάβανος, ο τελευταίος Πάρθος βασιλιάς νίκησε στη μάχη της Νίσιβης τον αυτοκράτορα Μακρίνο, ο οποίος μετά την ήττα του αναγκάστηκε να συνάψει ειρήνη με τους Πάρθους. Στο δεύτερο μέρος επικεντρώνεται το ενδιαφέρον μας στις διπλωματικές σχέσεις μεταξύ της Ρώμης και Περσίας και της Παλμύρας με τις δύο προαναφερθείσες δυνάμεις. Συγκεκριμένα, σκιαγραφούνται και αναλύονται οι επαφές του Αλέξανδρου Σεβήρου με τον Αρντασίρ Α , του Φιλίππου του Άραβα και του Βαλεριανού με τον Σαπώρ Α , του Πρόβου με τον Βαράμη Β , του Οδαίναθου με τον Σαπώρ Α και τον Γαλλιηνό και της Ζηνοβίας με τον Βαράμη Α και τον Αυρηλιανό.
Πρόβλεψη δραστικών τεχνολογιών στον τουρισμό με ασαφή λογική
Authors: Ατσαλάκη Ιωάννα
Published: September 2022

Ο κόσμος συνεχώς αλλάζει εξαιτίας των νέων τεχνολογικών καινοτομιών που επινοεί η επιστήμη. Η ανάγκη για πρόβλεψη των αλλαγών που φέρνουν οι νέες καινοτομίες είναι πρωταρχικής σημασίας για την επιβίωση των οργανισμών. Οι νέες τεχνολογίες φέρνουν ταυτόχρονα ευκαιρίες αλλά και απειλές. Η μη έγκαιρη πρόβλεψη τους θα έχει ως συνέπεια ο οργανισμός να υποστεί τις αρνητικές επιπτώσεις από τις απειλές των νέων τεχνολογιών και να μην αξιοποιηθούν οι ευκαιρίες που αργά η γρήγορα θα εμφανιστούν. Οι νέες τεχνολογίες μπορεί να προκαλούν μικρές βελτιώσεις ή πολύ δραστικές αλλαγές, οι οποίες αναστατώνουν πλήρως τις υπάρχουσες δομές μιας αγοράς. Η αποτυχία πρόβλεψης, κυρίως των δραστικών τεχνολογιών, θα επιφέρει σε πολύ μικρό χρονικό διάστημα, ακόμα πιο αρνητικά αποτελέσματα στον οργανισμό. Οι δραστικές τεχνολογίες από μόνες τους δεν επιφέρουν έσοδα. Αντιθέτως, μόλις ενσωματωθούν σε ένα επιχειρηματικό μοντέλο επιφέρουν μεγάλης έκτασης αλλαγές στον τομέα και απειλούν πολλές φορές με αφάνεια ακόμα και τις μεγάλες, καλά εδραιωμένες επιχειρήσεις στον τομέα. Επίσης, μια νεοεισερχόμενη επιχείρηση στην αγορά που ενσωματώνει νέες τεχνολογίες έχει ανάγκη από ένα μοντέλο που να μπορεί να προβλέψει εάν θα επιφέρει δραστικές μεταβολές στην αγορά και εάν θα καταφέρει, να παραμένει και να κατακτήσει ικανό μερίδιο της αγοράς.Η ασαφής λογική, καθώς αναπαριστά τον τρόπο που σκέπτεται το ανθρώπινο μυαλό με την χρήση λέξεων και λογικών κανόνων, μπορεί να μοντελοποιήσει αρκετά ικανοποιητικά, προβλήματα όπου κυριαρχεί η αβεβαιότητα, εξαιτίας της αμφιβολίας, της έλλειψης πληροφοριών και των ανακριβών δεδομένων. Στην παρούσα διατριβή αποδεικνύεται ότι η ασαφής λογική έχει τα μέσα να υπολογίσει με μεγάλη επιτυχία, την αβεβαιότητα που μια δραστική τεχνολογία επιφέρει, όπως ακριβώς έχει κάνει και σε πολλούς άλλους τομείς. Αναπτύχθηκε ένα ασαφές μοντέλο έχοντας ως μεταβλητές εισόδου την «Τιμή», την «Ποιότητα- Εξυπηρέτηση», την «Ευκολία Πρόσβασης» και την «Μη εξυπηρετούμενη ανάγκη» και ως έξοδο την «Δραστική Αλλαγή», εκμαιεύοντας την γνώση των ειδικών. Αρχικά οι ειδικοί αξιολόγησαν το προτεινόμενο μοντέλο. Στην συνέχεια η αξιολόγηση έγινε με πραγματικά δεδομένα που αφορούσαν την Airbnb. Το μοντέλο προέβλεψε ότι από τον πρώτο χρόνο λειτουργίας της εταιρίας, το 2010, θα γινόταν κυρίαρχη στην αγορά καταλυμάτων, δηλαδή 7 έτη νωρίτερα από την εμφάνιση των πρώτων μελετών για την δραστική αλλαγή που επέφερε η Airbnb στην αγορά. Το Δεκέμβρη του 2020 εισήχθη στο χρηματιστήριο με αξία $87 δις, όταν η αξία της αλυσίδας ξενοδοχείων Marriot ήταν $42 δις και Hilton $29 δις.
Πήλινα ειδώλια του στρώματος καταστροφής της αγοράς της Πέλλας
Authors: Πουλακάκης Νεκτάριος
Published: September 2022

Η διδακτορική διατριβή ασχολείται με τη μελέτη 310 πήλινων ειδωλίων που προέρχονται από την Αγορά της αρχαίας Πέλλας και ειδικότερα από το στρώμα καταστροφής των αρχών του 1ου αι. π.Χ. είκοσι τεσσάρων (24) χώρων του νότιου τμήματος της ανατολικής στοάς. Τα ειδώλια που περιλαμβάνονται αποτελούν ένα αντιπροσωπευτικό δείγμα ενός μεγάλου κοροπλαστικού συνόλου που βρέθηκε σε θραυσματική κατάσταση κατά την ανασκαφική έρευνα της Αγοράς τα έτη 1980 – 1984 και 2006-2007. Η μελέτη είχε κύριο στόχο να περιγράψει το υλικό, να αναλύσει και να ερμηνεύσει το κοινωνικό, οικονομικό, θρησκευτικό και πολιτιστικό πλαίσιο μέσα στο οποίο αυτά κατασκευάζονται και χρησιμοποιούνται, να ανιχνεύσει πιθανές σχέσεις των εργαστηρίων μεταξύ τους ή με εργαστήρια άλλων περιοχών και, τέλος, να συνεισφέρει σε ακόμα μεγαλύτερο βαθμό στη γνώση μας για την κοροπλαστική παραγωγή των εργαστηρίων της Πέλλας κατά την ύστερη ελληνιστική εποχή. Η εργασία παρουσιάζει ένα πολυποίκιλο υλικό, που προέρχεται από καταστήματα-εργαστήρια παραγωγής ειδωλίων, από χώρους δηλαδή που κατασκευάστηκαν μαζικά. Επιπλέον, αφορά ένα σύνολο που χρονολογείται κατά βάση σε ένα στενό χρονολογικό πλαίσιο, κατά την εποχή καταστροφής της πόλης στις αρχές του 1ου αι. π.Χ., και ως εκ τούτου αποκαλύπτει την παραγωγή των εργαστηρίων κατά την τελευταία φάση της ζωής της. Διαπιστώνεται ένα σημαντικό θεματολογικό εύρος στις προτιμήσεις των κοροπλαστών. Η παρουσία νέων τύπων ειδωλίων στην Πέλλα και οι σχέσεις και επαφές με κοροπλαστικά εργαστήρια άλλων περιοχών αποκαλύπτει ένα δυναμικό κλάδο της οικονομίας της την εποχή αυτή, όταν η πόλη έχει πάψει μεν να αποτελεί το κέντρο των πολιτικών εξελίξεων, παραμένει ωστόσο ένα σημαντικό οικονομικό κέντρο της Μακεδονίας.
Διαμόρφωση και λειτουργία εργαστηρίων δημιουργικής γραφής στην άτυπη εκπαίδευση ενηλίκων
Authors: Ελένη Γκόρα
Published: September 2022

Η παρούσα Διδακτορική Διατριβή (Δ.Δ.) έχει ως θέμα τη διαμόρφωση και τη λειτουργία Βιωματικών Εργαστηρίων Δημιουργικής Γραφής (Β.Ε.Δ.ΓΡ.) στην άτυπη εκπαίδευση ενηλίκων. Αρχικά, αυτή η Δ.Δ. προσεγγίζει θεωρητικά όρους και προϋποθέσεις σχετικά με τη «Λογοτεχνία», τη «Δημιουργική Γραφή», και τα «Βιωματικά Εργαστήρια Δημιουργικής Γραφής». Στη συνέχεια, αναλύει την έρευνα και τη μεθοδολογία στα Βιωματικά Εργαστήρια Δημιουργικής Γραφής Ενηλίκων. Πιο συγκεκριμένα η Δ.Δ., εξηγεί τον τρόπο προώθησης των Β.Ε.Δ.ΓΡ. που οργανώνει η υποφαινόμενη ερευνήτρια, σημειώνει τα ποσοστά ανταπόκρισης, εξετάζει το προφίλ των συμμετεχόντων στα Β.Ε.Δ.ΓΡ. με τη χρήση ερωτηματολογίου, σχεδιάζει και υλοποιεί σύγχρονες και καινοτόμες προτάσεις διδασκαλίας, συγκεντρώνει τα παραγόμενα κείμενα των συμμετεχόντων και διασφαλίζει την ποιότητα των Β.Ε.Δ.ΓΡ. μέσω της αξιολόγησης. Ακολούθως, η Δ.Δ. παρουσιάζει τα αποτελέσματα των Β.Ε.Δ.ΓΡ. Ακόμη, η παρούσα Δ.Δ. αναλύει και συζητά τα δεδομένα που συνέλεξε με σκοπό να ανιχνεύσει/προβλέψει το μέλλον της Δ.ΓΡ. στον χώρο αυτόν στην Ελλάδα και να δημιουργήσει υλικοτεχνική υποδομή για περαιτέρω έρευνες. Τέλος, παραθέτει τη σχετική και ειδική βιβλιογραφία που χρησιμοποίησε, ενώ συμπεριλαμβάνει στο παράρτημα τις φόρμες πρόσκλησης των Β.Ε.Δ.ΓΡ., τις φόρμες συμμετοχής, τα παραγόμενα κείμενα και τις φόρμες αξιολόγησης.
Rural Cardiac Screening: Leveraging Technology from a Previously Established Echocardiographic Network
Authors: Johnson Theresa , Skipper Eric R. , Robicsek Francis
Published: September 2022

Objectives:  The authors review the history of two cardiac programs in Guatemala and Belize that were initiated by the late Dr. Francis Robicsek.  Building upon his legacy, the aim of the rural cardiac screening program is to further extend the reach to those individuals disenfranchised from cardiac services.

Methods:  Complementary to the Nan Van Every Cardiology Diagnostic Network, screening stations are organized once a year at two cardiac echo stations in Guatemala and two clinics in Belize. Demographic information and medical history are collected; limited physical and diagnostic tests performed; and results are reviewed by a cardiologist and relayed to the participant. Participants with a suspected heart issue are referred to one of the cardiology and cardiac programs in Guatemala or Belize for in-depth evaluation.  Education on cardiovascular diseases, signs, symptoms, and risk factors is provided, as well as healthy lifestyle habits. 

Results:  Building upon successful cardiac programs in low resource settings lends the ability to expand the cardiovascular screening and awareness reach. Heart disease is brought to the forefront in communities where there is no previously known access and clinicians are educated to identify heart problems.

Conclusion: The success of Unidad de Cirugía Cardiovascular de Guatemala (UNICAR) in Guatemala City, and the cardiology and cardiac surgical programs at Karl Heusner Memorial Hospital Authority in Belize, and the Nan Van Every Cardiology Diagnostic Network, are the cornerstones to scaling the expansion and encounter individuals who have little, if any, knowledge about cardiac diseases, signs, symptoms and prevention.
Review of sustainable Paediatric Cardiac Surgery Program based on Humanitarian Principles at Govt. Medical College, Goa
Authors: Kolwalkar Jagannath , Agarwal Ravi , Borkar Shirish , Sunil Vidya Sagar , Vijay Madhan
Published: September 2022

Introduction:  Paediatric cardiac surgery and paediatric cardiology set-up is an arduous task, in developing countries, like India (4). Access to advanced cardiac care is unavailable in majority of developing countries (5). Due to high fertility rates in India, the annual estimate of CHD is approximately 150,000–200,000 children per year (6, 10). Of these, approximately a third to a quarter (∼50,000) would need early intervention to survive the first year of life (7, 10).  Goa is a small state of India situated along the western coast of Indian peninsula. Goa medical college (GMC) is the only tertiary level institute, providing medical facilities in the state. There were no cardiology or cardiac surgical facilities available at GMC, prior to 2014. The cardiac surgical unit at Goa Medical College was started in April 2014. It provides cardiac surgical services absolutely free of cost to all the citizens of the state. Initially only adult cardiac surgical cases were being performed, but from September 2014, we initiated the paediatric cardiac surgical program, for which we availed the facility of a paediatric cardiac surgeon. Materials and Methods: From 26th Sep 2014 to 11th Jan 2020, we operated a total of 90 cases, during 18 visits of the visiting paediatric cardiac surgeon, who operated an average of 5 cases per visit. Mean age of operated children was 3.2 years. We operated 34 cases of VSD’s, 26 cases of TOF, 8 cases of Tricuspid atresia, 9 cases of ASD, 3 cases of MV repair, 1 case of ASD+PS, 5 cases of TAPVC, 3 PA banding & PDA ligation and one permanent pacemaker implantation. Patients were managed initially in a 5 bedded ICU and after extubation were shifted to a step-down ICU for further recovery. Results: The average duration of ventilation was 36hrs and average length of ICU stay was 5 days. Mean CPB time was 92.46 mins and mean aortic cross clamp time was 59.5 mins. Overall mortality was 5.55%. One patient underwent a redo MV repair, as there was moderate residual MR in post operative period. Conclusion: This model of cardiac surgical program has worked well for the state of Goa and has benefitted lot of people from within the state as well as neighbouring states, where easy and affordable access to cardiac surgical facilities are missing. It has produced excellent outcomes for adult cardiac surgery and has encouraged us to extend the facility to paediatric population. Gradually, our local team is getting confident to do these paediatric cases.

Keywords: Congenital heart disease, India, Goa medical college (GMC), Paediatric cardiac surgical care.
Prevalence, causes and impacts of human trafficking in Asian countries: A scoping review
Authors: Khan Zeeshan , Kamaluddin Mohammad Rahim , Meyappan Saravanan , Manap Jamiah , Rajamanickam Ramalinggam
Published: September 2022

Background: In Asian countries, human trafficking is often encountered as forced labor, forced marriage, sex trafficking, men, women, and children exploitation. This review points out how human trafficking activities are prevalent in Asian countries and also reveals different causes that are the basis of increasingly human trafficking in Asian countries such as poverty, unemployment, political uncertainty, war, natural disaster, corruption and weak policies. Human trafficking also creates huge health, physical, psychological and social implications on individuals and the overall society.

Methods: The purpose of this study is to collect evidence on human trafficking in Asian countries. A scoping review methodology was used to systematically search online databases including Sage Journals Online, Wiley Online, Hein Online, Taylor & Francis Online, Web of Science, and Scopus literature to amalgamate information on this issue. For the purposes of this article, 64 studies met the inclusion criteria after searching and screening a total number of 1,278 studies.

Results: The findings of this study were classified under three categories: prevalence of human trafficking in Asia, causes of human trafficking in Asia (poverty and unemployment, environmental and manmade disaster, weak policies and corruption), and impacts of human trafficking including social, health, physical, psychological impacts.

Conclusion: Keeping in mind the prevalence and impacts of human trafficking, the author also recommends some meaningful and practical steps for policymakers and researchers to effectively tackle human trafficking in Asian countries.
A simple method for fish silage production: Using yoghurt as inoculum
Authors: Özkütük Ali Serhat , Özyurt Gülsün
Published: September 2022

The evaluation of seafood processing wastes is an important issue in terms of both preventing environmental pollution and adding value to these wastes economically. The most practical method that can convert seafood processing waste into a valuable feed source and plant fertilizer is to make silage. In this study, the ripening times and nutritional components of fish silages prepared with direct addition of lactic acid bacteria culture (Streptococcus thermophilus), acidifying chemicals (formic acid) and yogurt, which is a fermented food, were compared. In the research, sardine fish (Sardina pilchardus) wastes (head, skin, bones, internal organs, etc.) were used in fish silage production. It was observed that all fish silages completed the ripening phase within a maximum of 10 days. It was determined that the moisture, ash, protein and lipid contents of the groups prepared with acid, bacteria and yoghurt ranged between 63-66%, 5.6-5.7%, 11.3-11.8% and 12.18-13.65%, respectively. As a result of the research, it was observed that fish silages made with the addition of yoghurt as an alternative to silages made with direct addition of pure bacterial culture or acid addition met the expectations in terms of both ripening time and nutrient components.
Bupropion - an antidepressant drug with broad therapeutic potential
Authors: Bróż Sebastian , Dankiewicz Sara , Żelazny Przemysław , Filipczak Joanna , Swora Aleksandra , Borowik Joanna , Sygacz Oliwer , Brodowski Wojciech , Pawłowski Piotr , Basta-Arciszewska Katarzyna
Published: September 2022

Introduction: Bupropion is currently mainly used as an atypical antidepressant due to its psychotropic effects. In addition, it shows high potential in reducing withdrawal cravings in addicts, which is also used in the treatment of nicotinism. However, studies in recent years have shown that it may also be useful in other conditions.Aim of the study: Our aim was to review the known usage of bupropion in the fields of psychiatry, neurology and internal medicine, and to identify potential directions for further research. Methods and materials: We reviewed the literature available in the PubMed database, using the key words: "bupropion"; "depression"; "smoking cessation"; "obesity"; "ADHD".Results: Bupropion- an antidepressant drug belonging to the group of selective norepinephrine and dopamine reuptake inhibitors. Bupropion is approved by the FDA(Food and Drug Administration) for the treatment of depression, seasonal affective disorder and nicotinism. The literature shows that it is also effective in off-label indications - treatment of antidepressant-induced sexual dysfunction, attention deficit hyperactivity disorder (ADHD), depression in bipolar disorder, obesity, neuropathic pain and cancer-related fatigue syndrome.Conclusion: Due to the specific effects of bupropion, there are many more usage for the drug than the primary indications for which it is usually used. The usage of the drug described in the literature require additional studies on a larger group of patients.
Hallux valgus treatment and new methods
Authors: Wojcik Bartlomiej , Fabiś Mateusz , Zadrożna Karolina , Małek Anna , Iwaniszyn-Zapołoch Klara , Remjasz Klaudia , Aleksandrowicz Jakub , Siedlecki Wojciech
Published: September 2022

Introduction: Hallux valgus is a common disease more common in women In this article, we reviewed the epidemiology, symptoms, and various surgical techniques for the treatment of hallux valgusMaterial and methods: The work was based on medical articles collected in PubMed, websites and medical books. The research was conducted by looking at keywords such as: "hallux treatment", "hallux disease"Results: There are many methods of treating hallux valgus, ranging from conservative treatment to surgical treatment.Conclusions: The interdisciplinary approach to the patient and innovative surgical techniques can provide us with many new solutions in the treatment of the disease.Doctors have to adjust treatment to provide the best therapeutic effects.
Overexcitability in children aged 8 and 9 in parents’ perception. Does sex matter?
Authors: Limont Wiesława Anna , Łukasiewicz-Wieleba Joanna Teresa , Demianowska Agnieszka , Jabłonowska Małgorzata
Published: September 2022

Wzmożone pobudliwości psychiczne (OE) przejawiające się w intensywnym, emocjonalnym i głębokim przeżywaniu, są częścią potencjału rozwojowego w Teorii Dezintegracji Pozytywnej Kazimierza Dąbrowskiego. Większość badań OE prowadzona jest z osobami uzdolnionymi z wykorzystaniem samooceny. Niniejsze badanie przeprowadzono wśród dzieci losowo dobranych z ogólnoszkolnej populacji, z wyłączeniem selektywnego kryterium wybitnych zdolności. Za pomocą Overexcitability Inventory for Parents (OIP-II) zebrano opinie rodziców na temat profili OE ich dzieci. OIP-II składa się z sześciu skal: psychomotorycznej, sensualnej, wyobrażeniowej, intelektualnej OEs oraz wrażliwości emocjonalnej i empatii emocjonalnej. W badaniu wzięło udział 116 rodziców dzieci w wieku 8 lat (n=42, 26% dziewczynek) i 9 lat (n=74, 50% dziewczynek). Wielowymiarowa analiza wariancji (MANOVA) wykazała, że dziewczęta uzyskały statystycznie istotnie wyższe wyniki niż chłopcy w  sensualnej OE (p<.05) i empatii emocjonalnej (p<.01). Starsze dziewczęta uzyskiwały wyższe wyniki (p<.01) w sensualnej OE, a młodsze w empatii emocjonalnej. Nie znaleziono profilu OE chłopców. Nowością w niniejszym badaniu jest losowy dobór dzieci z ogólnej populacji oraz wykorzystanie OIP-II. W dyskusji prezentowane są możliwe wyjaśnienia i interpretacje wyników, w tym sugestie kierunku dalszych badań.
Personal and Social Education Carried out by Polish Primary Schools during the COVID-19 Pandemic – Two Insights into Early Childhood Education
Authors: Zubala Ewelina , Wichrowska Kamila , Marchlik Paulina
Published: September 2022

Remote education caused by the spread of SARS-CoV-2 virus proved to be a difficult experience for all of its participants. Teachers and parents faced logistical and organisational challenges in teaching young children, but were equally affected by educational and socio-emotional development issues. The aim of this article is to present how personal and social education (PSE) was carried out by Polish teachers of the first three grades of primary school during remote classes. The authors conducted an empirical qualitative study in early 2021, before the third school closures in Poland. The study involved 20 teachers and 20 parents of pupils in grades 1–3 of public primary schools from the Mazovian voivodeship. A semi-structured interview was used to explore the experiences of the respondents and obtain information to address the research question: “How was personal and social education carried out by teachers during remote education in grades 1–3 of Polish primary schools in the COVID-19 pandemic?”, which referred to the activities used by teachers to implement remote personal and social education, as well as the parents’ and teachers’ opinions as regards this process. The conclusion pointed out by the majority of respondents was the need to adapt to utterly new conditions, to focus on the emotional and social needs of the youngest pupils being the result of an unfamiliar, remote reality. The PSE with the youngest pupils during the pandemic was carried out in two ways: prevention and intervention. Prevention took place during everyday meetings, and took the form of a talk about their experiences from the previous day or anything that mattered to childrenwithin the time of the online classes. Intervention took place only when needed, and took such forms as an individual conversation with the pupil, a conversation with a parent or other.
Time Perspective and Experience of Depression, Stress, and Loneliness Among Adolescents in Youth Educational Centres
Authors: Dąbrowska Anna , Marek-Banach Joanna , Łopatkiewicz Agata , Wysocka Ewa , Zimbardo Philip
Published: September 2022

Time perspective is of key significance in overcoming an identity crisis in adolescence. Research using the Zimbardo Time Perspective Inventory (ZTPI) was conducted on a group of 311 adolescents (aged 13–18) in several youth educational centres in south-eastern Poland. The research was designed to identify the significance of time perspective when it comes to levels of depression, stress and loneliness experienced in conditions of institutional rehabilitation and education. Linear regression analysis demonstrated the following: a positive past focus reduces the intensity of anxiety and depression; a positive past and future focus results in reduced depression, loneliness and stress; the experience of stress combined with depressionenhances the significance of time perspective for the feeling of loneliness; and a low level of family loneliness reduces depression.
Relationships of the Big Five Personality with Self-Esteem and Emotion Understanding in Students from Visual Arts High Schools and General Education High Schools
Authors: Kuśpit Małgorzata , Tychmanowicz Anna
Published: September 2022

The problem of the present study was defined as follows: What personality characteristics were predictors of emotion understanding and self-esteem in students of visual arts high schools and general education high schools. The  problems discussed in this article have important implications for the effective functioning of artistically gifted youth in the school environment and for the optimization of their development in various areas of activity. Students of visual arts and general education high schools (N = 440) aged 15–18 (M = 16.88, SD = 0.81) in Poland were surveyed. The participants completed Costa and McCrae’s NEO-FFI, Rosenberg’s Self-Esteem Scale (SES), and Matczak and Jaworowska’s Emotion Understanding Test (TRE). Enter regression analysis was conducted. The results showed that in the group of visualarts high school students neuroticism, extraversion, and conscientiousness were significant predictors of self-esteem, while neuroticism and openness to experience were predictors of emotion understanding. In the group of high school students who pursued a general educationcurriculum, self-esteem was statistically significantly predicted by neuroticism and conscientiousness. Significant predictors of emotion understanding in this group of students included neuroticism, extraversion, openness to experience, and agreeableness. These findings demonstrate that the students functioned differently in the school setting depending on the educational curriculum they were following. The results of the present study can be used to formulate practical educational guidelines.
A Combined Simulation-Optimization Approach for Robust Timetabling on Main Railway Lines
Authors: Högdahl Johan , Bohlin Markus
Published: September 2022

Performance aspects such as travel time, punctuality, and robustness are conflicting goals of utmost importance for railway transports. To successfully plan railway traffic, it is therefore important to strike a balance between planned travel times and expected delays. In railway operations research, a lot of attention has been given to construct models and methods to generate robust timetables—that is, timetables with the potential to withstand design errors, incorrect data, and minor everyday disturbances. Despite this, the current state of practice in railway planning is to construct timetables manually, possibly with support of microsimulation for robustness evaluation. This paper aims to narrow the gap between the state-of-the-art optimization-based research approaches and the current state of practice to construct timetables by combining simulation and optimization. The paper proposes a combined simulation-optimization approach for double-track lines, which generalizes previous work to allow full flexibility in the order of trains by including a new and more generic model to predict delays. By utilizing delay data from simulation, the approach can make socioeconomically optimal modifications of a given timetable by minimizing predicted disutility—the weighted sum of scheduled travel time and total predicted delay. In a large simulation experiment on the heavily congested Swedish Western Main Line, it is demonstrated that compared with a real-life, manually constructed timetable, large reductions of delays as well as improvements in punctuality could be obtained for a small cost of marginally longer travel times. The cost of scheduled in-vehicle travel time and mean delay was reduced by 5% on average, representing a large improvement for a highly utilized railway line. Furthermore, a separate scaling experiment indicates that the approach can also be suitable for larger problems.

Funding: This research was funded by Trafikverket [Grants TRV 2016/5090 and TRV 2020/72690].
Insulinoma-related Endogenous Hypoglycaemia with a Negative Fasting Test: A Case Report and Literature Review
Authors: Prieto-Saldarriaga Carolina , Builes-Montaño Carlos Esteban , Arango-Toro Clara Maria , Manotas-Echeverry Cindy , Pérez-Cadavid Juan Camilo , Álvarez-Payares José C , Rodriguez Arrieta Luis Antonio
Published: September 2022

We present the case of a patient with a history of symptomatic hypoglycaemic episodes and a negative 72-hour fasting test with histological confirmation of insulinoma. A literature review of hyperinsulinaemic hypoglycaemia with a negative fasting test was performed.
Debunking health and safety myths
Authors: Bernstein Adam
Published: September 2022

Health and safety is a perennial problem for employers in all business sectors and having a correct understanding of the law can make all the difference to employers seeking to stay out of trouble, says Adam Bernstein, in collaboration with Phil Crosbie, Sarah Valentine, Amy Sadro, Catherine Henney and Paul Verrico
Four situations when aesthetic practitioners need to say no
Authors: Underdown Pam
Published: September 2022

It is important for clinic owners to be able to say no to patients. Pam Underdown shares four situations when practitioners need to say no and provides five scenarios for readers to refer to