bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Dapita (Dakon Pintar Matematika) Sebagai Media Pembelajaran Materi Penjumlahan Dan Pengurangan
Authors: Salafiyah Jihan Ainis , Zuliana Eka , Kuryanto Mohammad Syaffruddin
Published: December 2024

The purpose of this study is to determine the results of validation tests, effectiveness test results, and practicality test results of the development of traditional Dapita games (Dakon Pintar Mathematics) as a learning medium for addition and subtraction material for grade II elementary school students. The development of this research uses the ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The data used in this study are qualitative data and quantitative data. Data analysis techniques in this study use quantitative descriptive analysis techniques. The validity test in this study uses the Aiken V Index. The validation results obtained on the media aspect are 0.940741 are included in the very valid category. The validation results obtained on the material aspect are 0.911111 are included in the very valid category. The effectiveness test in this study used the Mann Whitney and N-Gain tests.  Posttest statistical tests in experimental classes with control classes with the Mann Whitney technique obtained Asymp results. Sig. (2-tailed) 0.000 0.05 with experimental class mean rank of 31.20 and control class mean rank of 11.29. The results of the experimental class Mann Whitney pretest and posttest showed a pretest mean rank value of 10.90 and a posttest mean rank of 30.10 and the significance showed an Asymp value. Sig.  (2-tailed) 0.000 0.05. The results of pretest and posttest tests in the experimental class are known to mean N-Gain value of 0.7894 is included in the high effectiveness category. The results of the pretest and posttest N-Gain tests in the control class are known to mean N-Gain values of 0.3387 included in the medium effectiveness category. The practicality test of Dapita learning media (Dakon Pintar Mathematics) obtained a score with a presentation of 95% in the very practical category
Efektivitas Model Problem Based Learning Berbantuan Media KIT IPA terhadap Kemampuan Berpikir Kritis Siswa
Authors: Izharifa Febrisa Rifda , Fakhriyah Fina , Masfuah Siti
Published: December 2024

The aim of this research is to analyze the average increase in students' critical thinking abilities before and after using the PBL model assisted by KIT IPA media. This type of research is pre-experimental with a one group pretest-posttest design. The sample in this study consisted of 23 fifth grade students at SD 6 Tanjungrejo. The sampling technique uses purposive sampling technique. The data collection techniques used in this research are tests and non-tests. The technical test is used to measure students' critical thinking abilities in the form of 10 essay questions. The non-test techniques used are interviews and documentation. The data analysis technique used in this research uses the n-gain test using SPSS 23 software which has previously been tested as a prerequisite in the form of a data normality test. The research results show that the n-gain percentage value is 67% in the medium category. Based on these results, there was an increase in students' critical thinking abilities after the PBL model assisted by KIT Science media was implemented.
Univalence conditions of an integral operator on the exterior unit disk
Authors:   "Babes-Bolyai" University,
Faculty of Mathematics and Computer Sciences,
1, Kog alniceanu Street,
400084 Cluj-Napoca, Romania
e-mail: oanamaria.trif@gmail.com, Parva Oana M. , Breaz Daniel V. ,   "1 Decembrie 1918" University of Alba Iulia,
510009 Alba Iulia, Romania
e-mail: dbreaz@uab.ro
Published: December 2024

Into this article, we consider the subclasses $ V_j, V_{j,\mu}$ and $\sum_j(p),$
with $j=2,3,...$, and generalize univalence conditions for the integral operator
$ G_{\alpha_i, \beta}$ of the analytic functions $g$ in the exterior unit disk.
We want to see if some univalent conditions for analytic functions obtained
on the interior unit disk can be extended on the exterior unit disk,
so we make use of the usual transformation
$$g(z)=\frac{1}{f(\frac{1}{z})} .$$
asalto digital al poder
Authors: García Martínez José María
Published: December 2024

El desarrollo contemporáneo de la tecnología tiene importantes consecuencias tanto económicas como políticas y sociales. En este artículo se abordarán brevemente algunas de las repercusiones observadas de las tecnologías del siglo XXI en los procesos electorales, tanto en Estados Unidos y Europa Occidental como en países del Sur global, considerando las importantes implicaciones que tiene el desarrollo tecnológico para la sociedad y la necesidad de una mayor investigación científica con el fin de comprender mejor estos procesos y evitar que esta tecnología conduzca a resultados socialmente perjudiciales o pueda emplearse para impulsar movimientos en contra de los valores democráticos.
implícita teoría social de Harari y cinco tesis sobre la IA
Authors: Zukerfeld Mariano
Published: December 2024

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Historical lessons for facilitating organizational recovery from crises
Authors: Poór József , Szalai Szilvia Módosné , Singh Dhruv Pratap , Jenei Szonja , Albert András , Pataki László
Published: December 2024

Our study is based on the premise that every crisis has historical precedents and antecedents. First, we analyze past crises, beginning with the experiences of the Dutch tulip bulb crisis. Then, we review major cataclysms, such as World War I, the Spanish flu crisis, the Great Depression of 1929–1933, World War II and the subsequent transition to socialism, the 1973 oil shock, the regime change of 1989, and the 2008–2009 global financial crisis from both general and corporate perspectives. Throughout history, periods of crisis have alternated with phases of development. During times of crisis, people’s behavior changes as they search for solutions and support. This pattern is evident across all levels of economic activity, where governments, organizations, and individuals do their utmost to achieve a quick recovery. Sometimes, they look to external aid, forgetting that lessons from the past may provide guidance for crisis management. Without claiming to be exhaustive, we have identified points worthy of consideration. Our goal is to offer guidance for business organizations, complemented by thoughts addressed to individuals and governments alike. Organizations must pay attention to the first signs of crises and either proceed according to a pre-developed fitting strategy or revise it according to specific circumstances. They cannot avoid the consequences, but they can mitigate the negative effects.
Variability of climate parameters and food crop yields in Nigeria: A statistical analysis (2010–2023)
Authors: Effiong Mfonobong Okokon
Published: December 2024

This study investigated the variability of climate parameters and food crop yields in Nigeria. Data were sourced from secondary sources and analyzed using correlation and multivariate regression. Findings revealed that pineapple was more sensitive to climate variability (76.17%), while maize and groundnut yields were more stable with low sensitivity (0.98 and 1.17%). Yields for crops like pineapple (0.31 kg/ha) were more sensitive to temperature, while maize, beans, groundnut, and vegetable yields were less sensitive to temperature with yields ranging from 0.15 kg/ha, 0.21 kg/ha, 0.18 kg/ha, and 0.12 kg/ha respectively. On the other hand, maize, beans, groundnut, and vegetable yields were more sensitive to rainfall ranging from 0.19kg/ha, 0.15kg/ha, 0.22 kg/ha, and 0.18 kg/ha respectively compared to pineapple yields which decreased with increase rainfall (−0.25 kg/ha). The results further showed that for every degree increase in temperature, maize, pineapple, and beans yields decreased by 0.48, 0.01, and 2.00 units at a 5 % level of significance, while vegetable yield decreased by 0.25 units and an effect was observed. Also, for every unit increase in rainfall, maize, pineapple, groundnut, and vegetable yields decreased by 3815.40, 404.40, 11,398.12, and 2342.32 units respectively at a 5% level, with an observed effect for maize yield. For robustness, these results were confirmed by the generalized additive and the Bayesian linear regression models. This study has been able to quantify the impact of temperature on food crop yields in the African context and employed a novel analytical approach combining the correlation matrix and multivariate linear regression to examine climate-crop yield relationships. The study contributes to the existing body of knowledge on climate-induced risks to food security in Nigeria and provides valuable insights for policymakers, farmers, government, and stakeholders to develop effective strategies to mitigate the impacts of climate change on food crop yields through the integration of climate-smart agricultural practices like agroforestry, conservation agriculture, and drought-tolerant varieties into national agricultural policies and programs and invest in climate information dissemination channels to help consider climate variability in agricultural planning and decision-making, thereby enhancing food security in the country.
Retrocessos democráticos contemporâneos: reflexões epistemológicas a partir de experiências no Sul Global
Authors: Câmara Heloisa Fernandes , Pack Ewerson Willi de Lima
Published: December 2024

A tendência de retrocesso democrático, constatada em diferentes regiões do mundo, fomentou a produção de novas explicações teóricas sobre a realidade política e o direito constitucional. Uma revisão da literatura indica a difusão de reflexões provenientes dos Estados Unidos e da Europa que, fundamentadas na teoria clássica da democracia liberal e do estado de direito, produziram conceitos aplicados em diversos contextos locais. Diante disso, e com enfoque na situação teórica e prática brasileira, esse estudo objetiva questionar e debater a possibilidade de aplicação de teorias externas em múltiplas realidades distintas e as dificuldades epistemológicas que esforços de classificação geral de regimes políticos podem enfrentar. Constata-se que as ideias se modificam durante a comunicação teórica entre diferentes lugares e autores, sendo importante, por isso, considerar as influências dos respectivos contextos na formação do conhecimento. Para o tema da democracia, em específico, teorias estrangeiras ajudam a entender estratégias antidemocráticas, sobretudo transnacionais, proporcionando atualizações epistemológicas tempestivas e relativamente verossímeis com as tensões contemporâneas, inclusive as brasileiras. Todavia, para a avaliação das respectivas causas, é necessária uma postura crítica às estruturas de dominação política e epistêmica do Norte Global, com a projeção de paradigmas baseados nas realidades do mundo periférico. Para tanto, a “tradução cultural” pode ser uma ferramenta útil para relacionar e reinterpretar teorias, construindo pontes entre mundos e identificando diferenças sem aceitação acrítica.
Palavras-chave: retrocessos democráticos; Sul Global; epistemologia e tradução cultural.
The Insertion of the English Language in the Early Years of Elementary School: an Analysis of Research Conducted Between 2018 and 2023
Authors: Oliveira Paulo Sérgio Silva , Souza Helenara Machado de
Published: December 2024

Objective: The purpose of this study is to identify how the topic of English Language Inclusion in the Early Years of Elementary School is addressed in research conducted between 2018 and 2023 on the CAPES Portal.
 
Theoretical Framework: The theoretical framework used underpins discussions on the topic of English language inclusion in the Early Years of Elementary School: an analysis of research conducted between 2018 and 2023 proposed in these materials. First, a theoretical framework is provided on children in the Early Years, who they are and how they develop, and then a deeper look is taken at the legal basis for teaching foreign languages ​​in Elementary School. Finally, a chapter is presented on the importance of introducing English language teaching to students in the Early Years of Elementary School.
 
Method: This study was conducted based on the theoretical assumptions of bibliographic research, with the analysis of 5 articles whose research was directly directed to the Early Years of Elementary School. As a data collection instrument, we chose to prepare a form in which relevant elements for the theme of this study were identified in the works analyzed.
 
Results and Discussion: Based on the development of the research presented here, it was found that early learning of a second language not only expands future academic and professional opportunities, but also enriches the cognitive and cultural development of students.
 
Implications of the Research: The practical and theoretical implications identified in this study are considered to be the reflections resulting from a discussion on the contributions arising from the inclusion of the English language in the Early Years of Elementary School.
 
Originality/Value: The relevance of this study is justified by the fact that it is considered that the inclusion of the English language in the initial years of elementary school is of utmost importance, as it provides children with a solid foundation in a globally dominant language from an early age. This early learning facilitates the acquisition of linguistic skills in a more natural and intuitive way, taking advantage of the cognitive plasticity characteristic of children in this age group. In addition, mastery of English opens doors to future academic and professional opportunities, promotes access to a vast amount of information and resources available in English, and facilitates communication in an increasingly globalized world.
The Use of “Forth Calcium” Fertilizer in Second-Season Corn Planting in the Center-West of Brazil
Authors: Bastos Rodolfo Junior Monteiro Magalhães , Almeida Júnior Joaquim Júlio de , Smiljanic Katya Bonfim Ataides , Matos Francisco Solano Araújo , Melo Junior Jair Pereira de , Miranda Beatriz Campos , Silva Victor Júlio Almeida , Silva Luis Filipe Almeida , Oliveira Danilo Marques , Garcia Emília da Costa
Published: December 2024

Objective: This study aims to use FortCálcio fertilizer as an alternative fertilizer option for corn crops in the central-western regions of Brazil.
 
Theoretical Framework: Corn quality depends on several characteristics, including proper soil management, choice of the right variety, and fertilizer application. Of all the nutrients a corn plant needs to grow healthily, calcium is essential. As an important component of the cell wall material in plants, calcium provides structure and rigidity.
 
Method: The methodology adopted for this research involves a scientific field study with a quantitative approach.
 
Results and Discussion: For the first time in the region, FortCálcio fertilizer is used to replace traditional “NPK mineral” fertilizers in corn cultivation. The use of this fertilizer achieved the objective of maintaining crop productivity above the national average, in addition to increasing productivity in relation to the absolute control “zero dose”.
 
Research Implications: The topics covered here are those that in the text portray a realistic vision of field application with an extensionist focus, aiming at improvements for rural producers.
 
Originality/Value: The contribution in terms of novelty that this research makes lies in the approaches that are taken and in new working methods and new applications. Its adequacy and values ​​are justified as being adequate by the statement that more research along the same lines is needed.
Diskussionsforum
Authors: Knapp Petra , Delanoy Elfrun , Guttenbrunner Katharina , Dieter Jadranka
Published: December 2024

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Die machtvolle Bedürftigkeit der frühen Objekte. Über die Auseinandersetzung mit aggressiven Selbst- und Objektrepräsentanzen mit Hilfe der Motivationsfrage
Authors: Rasch Georg
Published: December 2024

Eltern mit Defiziten und/oder ungelösten Konflikten können sich selbst stabilisieren, indem sie ihre Kinder ichsynton instrumentalisieren. Auf imaginativer Ebene stellt sich diese Thematik häufig in einer mächtigen, aggressiven Symbolgestalt dar. Mit der Frage nach dem Beweggrund der Gestalt für ihr Verhalten wird das System selbst in Frage gestellt und damit eine neue Ebene der Auseinandersetzung, ein Möglichkeitsraum geschaffen als Voraussetzung für eine progressive Änderung in Form einer Koexistenz von Patient und verfolgender Gestalt und mit größerer Autonomie des Patienten. Geduldiges Anwenden dieser Intervention und beharrliches Durcharbeiten können so auch in schwierigen Fällen zu einer Besserung führen.
Nachruf für Dr. med. Klaus Krippner
Authors: Dieter Wilfried
Published: December 2024

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Imaginative Nachlese
Authors: Bittner Josef
Published: December 2024

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Nostalgia y ruina: corporalidades cuir, decadencia y residuos en Las Malas de Camila Sosa Villada
Authors: Novoa Romero Alexandra
Published: December 2024

Este artículo analiza la novela Las Malas (2019) de Camila Sosa desde la nostalgia reflexiva (Boym),elación con la reconstrucción e interpretación del pasado irrecuperable que exhiben las ruinas de acuerdo con los planteamientos de Zambrano y Simmel, tanto en la arquitectura como en los cuerpos trans/travestis en decadencia. Asimismo, las corporalidades cuir serán consideradas residuos (Richard), seres marginados que constituyen vidas precarias, transformándose en cuerpos clandestinos y ambiguos. Sin embargo, aunque siempre reside en la comunidad trava el sentimiento de la no pertenencia, son sujetos portadores de significados que hacen visible una corporeidad alternativa a través de actos transgresores que bordea los márgenes sociales debido a que rompen con los espacios jerarquizados de identidad y género, de este modo, colmados de excesos posibilitan la pose y la transformación, redefiniendo otra imagen, un ser andrógeno que simula y disimula un rostro, una voz y un cuerpo monstruoso.
Quem são os adolescentes internados no Centro de Atendimento Socioeducativo em Mossoró/RN?
Authors: Alves Nogueira Jailson , Gomes de Oliveira Filho Erik Dênio
Published: December 2024

O presente artigo tem como objetivo apresentar as peculiaridades dos adolescentes que cumprem medida socioeducativa de internação no Centro de Atendimento Socioeducativo Mossoró, no estado do Rio Grande do Norte, Brasil. O trabalho tem um viés eminentemente empírico, em que foram analisados 10 instrumentos de coleta de dados referente às entrevistas realizadas com os adolescentes internados na referida instituição. Foram sistematizadas as informações coletadas, via projeto de extensão Direitos Humanos na Prática, da Universidade Federal Rural do SemiÁrido (UFERSA), em oito tabelas, as quais foram elaboradas por nós e posteriormente dialogadas com referenciais bibliográficos e dados oficiais. Assim, foi possível constatar que os sujeitos da pesquisa estão inseridos em contextos de vulnerabilidades socioeconômicas, negligenciados pela família, sociedade e Estado, o que afronta a Doutrina da Proteção Integral, prevista na Constituição Federal de 1988 e ratificada pelo Estatuto da Criança e do Adolescente (ECA).
LESÃO RENAL AGUDA EM UNIDADE DE TERAPIA INTENSIVA: CAUSAS, TRATAMENTO E DESFECHO
Authors: Alderete Geisyelli , Santos Viviane Soares dos , Ferreira Helder , Zilly Adriana , Silva Rosane Meire Munhak da
Published: December 2024

Introdução: A Lesão Renal Aguda é caracterizada pela diminuição transitória da capacidade de filtração glomerular e resulta em altos índices de mortalidade para os indivíduos em cuidados intensivos. Objetivo: Caracterizar os aspectos relacionados ao desenvolvimento da Lesão Renal Aguda, tratamentos e desfechos em uma unidade de terapia intensiva adulto. Materiais e Métodos: Pesquisa analítica, retrospectiva e quantitativa realizada em um hospital público de Foz do Iguaçu-PR. A população foi composta por 51 prontuários de indivíduos hospitalizados há mais de dois dias que evoluíram para Lesão Renal Aguda. Utilizou-se o teste Qui-Quadrado atribuindo o valor de p<0,05 para indicar significância estatística. Resultados: A maioria dos indivíduos com Lesão Renal Aguda tinha idade superior a 60 anos (62,7%), sexo masculino (57%), nacionalidade brasileira (92,2%) e hipertensão arterial (60,8%). Os sintomas iniciais foram anuria e/ou oligúria e edema (83,7). Evidenciou-se uso de antibióticos (90,3%), ventilação mecânica (80,4%) e uso de corticoides (84%). Os pacientes necessitaram de hemodiálise (23,5%) com frequência de uma vez ao dia (83,3%), com período de hospitalização acima de 14 dias (54,9%) e evolução ao óbito (45,1%). Conclusão: Ressalta-se a relevância da educação permanente, a fim de identificar de forma oportuna os aspectos relacionados ao surgimento dessa condição clínica, tendo em vista a alta mortalidade.
Empirical analysis of control models for different converter topologies from a statistical perspective
Authors: Rajendra Hole Shreyas
Published: December 2024

Converter topologies including SEPIC, ZETA, etc. are controlled via selection of capacitive & inductive components, which assists in improving its conversion efficiency for different type of loads. A wide variety of such models are proposed by researchers, that include, but are not limited to, bioinspired techniques for rating selection, Neural Network based models for load-based component selection, etc. Each of these models vary in terms of their internal operating characteristics, and showcase highly variant quantitative & qualitative performance under different loads. This variation increases the ambiguity of model selection under context-specific applications. To reduce this ambiguity, a detailed discussion about these models in terms of their context-specific nuances, qualitative advantages, deployment-specific limitations, and functional future scopes is described in this text. Based on this discussion, researchers will be able to identify optimal models for their application-specific use cases. It was observed that bioinspired models & incremental learning techniques assists in improving control performance for efficiency-aware use cases. This text also compares the evaluated models in terms of their conversion efficiency, cost of deployment, delay needed for control, scalability and computational complexity under different scenarios. Based on this comparison, researchers will be able to identify optimized models for their performance-specific deployments. This text further proposes evaluation of a novel Converter Control Rank Metric (CCRM) that combines these metrics, and assists in identification of converter control models that showcase high conversion efficiency with low delay, low complexity, high scalability, and low deployment costs. This will allow readers to select and modify optimized models for their context-specific use cases.
Contribution of the Balakirev music college of Nizhny Novgorod in the development of culture in Russia of the XX century
Authors:   Volga State University of Water Transport, Pakhomova Ye. A. , Fomenkov A. A. ,   National Research Lobachevsky State University of Nizhny Novgorod
Published: December 2024

The article is devoted to the most famous graduates and students of the Nizhny
Novgorod Music College in the early years of its existence. A number of cultural,
scientific and educational figures who studied at this educational institution at
the turn of the 1910–1920s are indicated. On the basis of unpublished sources,
information previously published in local history publications about the first famous
graduates of the Nizhny Novgorod Music College has been supplemented.
Parfitian Teletransportation or Error Management
Authors:   University of Tyumen, Kochnev R. L.
Published: December 2024

The article serves as a polemic commentary within the discussion on the possibility
of survival in teletransportation. It examines the principle of merorganic continuity
proposed by Alexey Kardash and supported by Konstantin Morozov. Several
counterarguments against merorganic continuity are presented, related to (1) the
principle’s insensitivity to crucial body parts, (2) the neglect of speed, and (3)
the degree of bodily change. It is discussed the problematic nature of so-called
‘ordinary survival’ and hypothesis is put forward regarding the reasons for differing
perspectives among researchers on survival in the context of teleportation.
Assessment of BCR /ABL variants and Survivin Gene Expression in Chronic Myeloid Leukemia Patients
Authors: Shivani U. , Shetty Reshma A. , Kadandale Jayarama S. , Krishna Rajesh , Shetty Prashanth D.
Published: December 2024

Chronic Myeloid Leukemia (CML) is a condition where blood cells proliferate abnormally forming the Philadelphia chromosome (Ph). This chromosomal aberration arises from the fusion of segments from chromosomes 9 and 22 through a reciprocal translocation. The present study focused on detection of chromosomal abnormalities and the role of survivin expression in different stages of CML. This descriptive study was conducted over a period of 3 years which constitutes 55 diagnosed CML patients. Cytogenetic tests revealed 27 (49%) patients in chronic phase (CP) with the Ph chromosome including 1 case with additional Ph copy and also a unique case with three way translocations. In accelerated phase (AP), 7(13%) patients were Ph+ve and 1 case was with isochromosome 17q and extra Ph copy. In blast phase (BP), 5 (9.0%) cases were characterised by the presence of t(9;22) and 1 case showed abnormality like gain of X chromosome and Y chromosome loss.

Additionally, 9 (16%) cases were Ph-ve. FISH analysis showed varied fusion patterns, with 30(54%) cases having typical fusion,18 (33%) showing heterogeneous signal patterns. 7(13%) were categorized as normal hybridization pattern signals. In our current study, Kaplan–Meier analysis indicated higher survivin expression correlated with shorter survival and lower expression linked to longer survival in CML patients.
Probiotic Strain Lactobacillus fermentum as a Potential Agent for the Reversal of Non-Periodontal Microorganisms Induced Cognitive Dysfunctions
Authors: Murugan Mukilan
Published: December 2024

The gastrointestinal tract of mammals consists of trillions of microorganisms including beneficial and non-beneficial floras termed as gut microflora. These beneficial gut microfloras are responsible for maintaining homeostasis mechanism of physiological functions including cognitive health. However, disturbance in this gut microflora results in the formation of gut dysbiosis. Gut dysbiosis results in the reduced synthesis and transport of neurotransmitter precursor compounds from the gut to the brain which causes impairment in the synthesis of neurotransmitters. The reduced synthesis of neurotransmitters further results in impaired cognitive memory formation. Formed cognitive impairment was reversed with the help of probiotic microorganisms. The present study explored the positive role of the probiotic strain Lactobacillus fermentum in the reversal of non-periodontal microorganisms (NPMs) induced cognitive impairment.

For identifying the effect of L. fermentum on the reversal of cognitive impairment, a three-phased behavioral analysis was used in the study. Behavioral studies were carried out for all experimental groups in different scenarios including a serene habituated environment with NPMs infusions and with L. fermentum infusions. Behavioral responses showed that a stress-free habituated environment plays a major role in the development of cognitive memory during the initial phase of behavioral analysis (IPBA). In mid phase of behavioral analysis (MPBA), IPBA-formed cognitive memory was impaired by the infusions of NPMs. Collective behavioral analysis proved that probiotic oral infusions in final phase of behavioral analysis (FPBA) played a major role in the reversal of induced cognitive impairment in experimental groups that received oral infusions of NPMs.
In silico screening of antifungal phytochemicals against Glomerella cingulata cutinase: Identification of potential inhibitors for Colletotrichum spp. Pathogenicity in chilli
Authors: Tyagi Aditya , Shanmugam Veerubommu , Kapoor Riti Thapar
Published: December 2024

Anthracnose, caused by Colletotrichum spp., is a significant disease affecting chilli, leading to considerable agricultural losses. This study aimed to identify natural inhibitors of Glomerella cingulata cutinase, a key virulence factor of Colletotrichum spp., through in silico methods. Thirty natural compounds known for their antifungal properties were selected and screened using SwissADME for drug-likeness and ProTox-II for toxicity, resulting in 20 non-toxic candidates. Molecular docking using AutoDock Vina revealed that Carvacrol and Eugenol exhibited the highest binding affinities (-5.4 kcal/mol and -5.1 kcal/mol, respectively), comparable to the standard inhibitor DCTC (-4.6 kcal/mol). Visualization and interaction analysis using Discovery Studio confirmed stable interactions of these compounds with key active site residues.

The study concludes that Carvacrol and Eugenol are promising eco-friendly antifungal agents, providing a basis for the development of sustainable treatments for anthracnose in chilli. Further experimental validation is warranted to confirm these findings and to explore their potential in agricultural applications.
GCMS profiling and molecular docking of antioxidant compounds partially purified from Ehretia laevis
Authors: Vivek K. , Abdhul K. , Mahendran D. , Karthik S. , Senthil Kumar V.
Published: December 2024

The present objective was to assess the phytochemical and in vitro antioxidant properties of Ehretia laevis ethyl acetate extract. Antioxidant activity was measured using the DPPH standard technique followed by purification using a solvent gradient based column and TLC. The DPPH positive fractions were analyzed using a gas chromatography technique. It was discovered that chloroform was more elute than hexane gradient in 22 distinct solvent gradient systems. Elution of fraction with hexane and water alone showed poor fractionation and no scavenging potential. Chloroform and methanol gradients gave maximum fractionation. Solvent chloroform/methanol at 1:1 ratio and at 3:7 ratio showed 74.6±1.15 66.6±1.17% DPPH free radical scavenging respectively. Fractions with Rf 0.64,0.73,0.82,0.9 cm exhibited strong free radical activity and their GCMS reveals presence of frequent novel compounds N-(t-butyl)-2-benzoylbenzamide, 1H-indolederivative, epoxycyclodecane-1-carboxylate, Naphtho[2,1-b]furan-6-carboxylic acid, 2(3H)-Furanone, 2-Fluoro-5-trifluoromethylbenzoic and isoquinolinone. In silico analysis reveals that the target having 5 active pockets were interacted with selected drug. The binding affinities of N'-acetyl-hydrazide ranged from −7.9 and 4-Fluoro-n-(2-methyl-1,3-dioxo-2,3-dihydro-1h-isoindol-5-yl)benzamide binding activity was -8.9kcal/mol.

According to the docked results, both compounds have the greatest affinity for the cancer target prptein and exhibit superior interaction with conserved catalytic residues. Additionally, ADMET experiments indicated that the phytochemicals' pharmacokinetics and toxicity characteristics were within acceptable bounds. According to the docked data, both compounds exhibit superior interaction with conserved catalytic residues and have the highest affinity for the epidermal growth factor. The presence of novel phytoconstituents' and their interaction ability promotes the traditional usage of E. laevis and offers crucial data for the development of cancer drugs.
Antibacterial Activity of Two Medicinal Herbs Species by using Various Organic Solvents Extraction
Authors: Nagarathinam T. , Raja Rajeswari Arumugam , Umamaheswari S.
Published: December 2024

Xanthium strumarium and Leucas aspera are promising medicinal plants as an excellent source of novel drugs to treat various diseases. The antibacterial activity of two different herb extracts was screened against seven pathogenic bacterial strains. Aqueous, methanol, chloroform and petroleum ether extracts of X. strumarium and L. aspera were subjected to tests of their antibacterial activity by agar disc diffusion method. The aqueous extracts of X. strumarium and L. aspera leaves against V. cholerae and S. aureus have revealed highest growth inhibition as 4 mm. The methanol crude extract against V. cholerae showed 5 mm. The chloroform crude extract against V. cholerae showed 7 mm and the petroleum ether crude extract against V. cholerae and P. aeruginosa have maximum zone of inhibition as 8 and 6 mm respectively.

The present study showed that antibacterial activity of medicinal herb X. strumarium is better than the L. aspera plants. The stronger extraction ability of petroleum ether and chloroform could have produced greater amount of the active constituents responsible for the higher antibacterial activity. In conclusion, the leaves of X. strumarium and L. aspera are good sources of antibacterial novel medicines.
Phytochemical characterization and the therapeutic efficacy of Fraxinus americana
Authors: Jyothsna Gundlapally , Sathvika Chintalapani
Published: December 2024

Fraxinus americana, a species commonly known as Ash tree is native to Eastern and Central North America and North Asia. This plant is known to posses a cluster of therapeutic properties. It is being used since ages in Unani and Ayurvedic medicine. Many infertility issues and gynecological problems can be treated by natural herbs and their extracts, Fraxinus is one such example. Objective of the current research is to characterize the various biochemical components present in the mother tincture of Fraxinus americana and testing its efficacy in treating uterine fibroids based on several biochemical and molecular assays.

Phytochemical analysis based on biochemical study was performed followed by TLC analysis. TLC would provide an insight to the array of components present in tincture along with the information about the suitable solvents for their separation. MTT assay can be used to test the efficacy of the sample in controlling cell division (anti cancer). Use of uterine fibroid related cell lines (Human Uterine Leiomyoma cell culture) would identify its role in this condition. In addition to anti cancerous activity by MTT, various other tests like anti inflammatory and antioxidant activity would be performed to annotate the complete therapeutic potential of Fraxinus americana. The study can lay a foundation for a green therapy eliminating the need for surgical procedures in treating several uterine problems.
Unraveling the Role of Non-Coding RNAs in Alzheimer's Disease
Authors: Siragam Satyalakshmi
Published: December 2024

Neurobiology provides profound insights into studying the molecular, cellular and systemic levels of pathophysiological processes, risk factors and potential therapeutic avenues associated with various neurodegenerative disorders. Alzheimer's disease (AMD) is a globally significant condition primarily affecting the elderly, necessitates an understanding of its connection to the nervous system. AMD poses a persistent challenge as an enigmatic neurodegenerative disorder impacting millions of people worldwide. Genetic approaches for the treatment and diagnosis of AMD offer distinct advantages compared to traditional treatments. This review shifts the spotlight to the intriguing realm of non-coding RNAs and their pivotal role in AMD pathogenesis. Non-coding RNAs constitute diverse class of RNAs which do not involve in protein synthesis but take significant part in regulation of genes and cellular mechanisms.

In recent years, emerging research has unveiled the substantial influence of various non-coding RNAs including microRNAs, long non-coding RNAs and circular RNAs, in the complex landscape of AMD. Non-coding RNAs have gained significant attention with their roles in mediating AMD-associated processes such as synaptic plasticity, amyloid precursor protein metabolism and oxidative stress. This review delves into the multifaceted functions of non-coding RNAs in AMD, shedding light on their regulatory mechanisms, their involvement in disease progression and their promise as diagnostic tools and therapeutic targets.
Mushroom and mushroom-derived compounds in the management of Leishmaniasis
Authors: Bhattacharya Ishita , Paul Santanu
Published: December 2024

Leishmaniasis is a zoonotically affected disease caused by the vector-borne parasite Leishmania and transmitted by an infected female Phlebotomine sandfly. It infects 2 million people every year causing more than 50000 deaths among the affected in nearly 100 endemic countries. Hepatosplenomegaly, musculoskeletal pain, kidney failure, chronic fever and a weakened immune system that is susceptible to some different diseases are the most prominent symptoms of the disease. Medical treatments are based on age-old antimonial and new therapies used in the treatment are the combination of drugs of liposomal amphotericin B, paromomycin and miltefosine. One of the principal challenges in these curatives is resistance, a long-term convoluted routine with a lot of disastrous side effects and high prices.

Naturally derived compounds can be one of the options in medical therapy and many anti-leishmanial compounds have been found from natural background till now with leishmanicidal properties. Mushrooms, one of the key members of nature, enriched with a plethora of bioactive molecules, play a vital role in the prevention of human diseases. To understand the progress in natural medicine, scientific reports published in ISI PubMed, Google Scholar, Scopus and Science Direct from 2006 to 2023 on mushrooms and mushroom-derived compounds having anti-leishmanial properties were summarized. In this study, we have tried to report the novel mushrooms and their potential to combat Leishmaniasis, revealing their mode of action which will be helpful in the future for the identification of bioactive molecules resourcing from mushrooms.
Герои народных сказок как инструмент преодоления когнитивных и лингвистических ошибок на занятиях по русскому языку как иностранному
Authors: Ли Ч. , Завьялова Н.А.
Published: December 2024

Статья посвящена анализу приема эффективного обращения к героям сказок на занятиях по русскому языку как иностранному. Авторы выдвигают концепцию, согласно которой преподаватели русского языка как иностранного могут обращаться к фольклору родных стран студентов, что способствует активизации процесса принятия учебной задачи иностранным студентом. Предлагаемая концепция прошла апробацию во время работы преподавателей в Исламской Республике Пакистан и Китайской Народной Республике. Авторы настаивают на необходимости тщательной проверки распространённых стереотипов о тех или иных героях иностранных сказок, поскольку непроверенные заблуждения могут также привести к когнитивным ошибкам, допущенным в свою очередь преподавателем. В статье представлены обзоры популярных сказок в Исламской Республике Пакистан, а также проанализирован сказочный сюжет возникновения китайского гороскопа. Авторы инициируют дискуссию о корректном переводе терминов китайского гороскопа.

The paper is devoted to the analysis of effective appeal to fairy tales’ characters during the classes of Russian as a foreign language. The authors put forward the concept according to which teachers of Russian as a foreign language can refer to the folklore of students' native countries, which helps activate the process of accepting an educational task by a foreign student. The proposed concept has been tested during the work of teachers in the Islamic Republic of Pakistan and the People's Republic of China. The authors insist on the need for careful verification of common stereotypes about certain characters of foreign fairy tales, since untested misconceptions can also lead to cognitive errors made in turn by the teacher. The article presents reviews of popular fairy tales in the Islamic Republic of Pakistan, as well as analyzes of the magical plot of the Chinese horoscope emergence. The authors initiate a discussion about the correct translation of Chinese horoscope terms.
Comparative characteristics of cardiometabolic disorders in the working population of indigenous and non-indigenous nationalities in Yakutia
Authors:   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Sofronova S.I. , Kirillina M.P. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Nikolaev V.M. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Romanova A.N. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru
Published: December 2024

A pilot study was conducted in the expeditionary conditions of the working population of the Anabar and Aldan districts of the Republic of Sakha (Yakutia). Arterial hypertension was registered equally frequently in more than half of the respondents. More than half of the respondents had abdominal obesity, and it was more often detected in non-indigenous men and women of indigenous nationality. Abdominal obesity and arterial hypertension are associated with atherogenic dyslipidemia in the indigenous population, most often in women. In non-indigenous people, regardless of gender, obesity correlated with TG levels and blood glucose, arterial hypertension with the same indicators in non-indigenous women.
Keywords: arterial hypertension, abdominal obesity, lipid metabolism, indigenous and non-indigenous population, Yakutia.
Криминологическая характеристика женской преступности
Authors: Газимагомедов М.А. , Никишкин А.В. , Ветрова Е.В.
Published: December 2024

Статья посвящена статистическому исследованию женской преступности в Российской Федерации с 2017 по 2021 год с целью выявления ее тенденций, а также возможных путей минимизации женской преступности. Приводятся количественные показатели уровня женской преступности за указанные пять лет, которые наглядно демонстрируют особенности и динамику развития женской преступности. Актуальность статьи обусловлена тем, что в современных условиях женская преступность как неотъемлемая часть преступности является серьезной угрозой для развития общества, для его социального и нравственного здоровья. Авторы исследуют структуру и специфику женской преступности, в которой выделены корыстные и насильственные преступления, названы виды преступлений, преимущественно совершаемые женщинами, подчеркнуты негативные тенденции женского криминального поведения.

The article is devoted to a statistical study of female crime in the Russian Federation from 2017 to2021 in order to identify its trends, as well as possible ways to minimize female crime. Quantitative indicators of the level of female crime for the indicated five years are given, which clearly demonstrate the features and dynamics of the development of female crime. The relevance of the article is due to the fact that in modern conditions, female crime as an integral part of crime is a serious threat to the development of society, to its social and moral health. The authors study the structure and specifics of female crime, in which mercenary and violent crimes are highlighted, the types of crimes predominantly committed by women are named, and the negative trends in female criminal behavior are emphasized.
Теоретические проблемы соотношения предмета, функций и метода трудового права
Authors: Рыженков А.Я. , Шаронов С.А.
Published: December 2024

Статья посвящена предмету трудового права. Отмечается, что трудовое право относится к числу тех отраслей российского права, в основе которых лежит кодифицированный законодательный акт, что означает, как правило, двойное определение предмета правового регулирования, который получает как доктринальное признание, так и официальное нормативное закрепление. Из трех основных признаков трудовых отношений: иерархичности, возмездности и договорного характера, – объективным, то есть присущим труду независимо от правового регулирования, является только первый, а именно наличие власти и подчинения; он действительно складываются в процессе коллективного труда как эффект его разделения. Что касается возмездности и договорного характера, то они являются чисто юридическими признаками, поскольку опираются на идею свободы как правовой ценности, в то время как практика трудовых отношений помимо правового регулирования, как известно, вполне допускает их бесплатность и принудительность. Основным методом регулирования в трудовом праве выступает метод компромисса. Он обусловлен тем, что изначально процесс правового регулирования происходит в условиях столкновения двух сторон с противоположными интересами, причем одна из них занимает более сильную позицию с социально-экономической точки зрения, а другая пользуется приоритетной защитой государства, исходящей из его политических интересов.

The article is devoted to the subject matter of labor law. It is noted that labor law is among those branches of Russian law, which are based on codified legislative act, which means, as a rule, double determination of the subject of legal regulation, which receives both doctrinal recognition and formal normative consolidation. Of the three main features of labor relations: hierarchy, compensation and contractual nature, only the first is objective, that is, inherent in labor regardless of legal regulation, namely the presence of power and subordination, which actually develop in the process of collective labor as an effect of its division. As for compensability and contractual nature, they are purely legal features, since they are based on the idea of freedom as a legal value, while the practice of labor relations in addition to legal regulation, as we know, quite admits their free and coercive nature. The main method of regulation in labor law is the method of compromise. It is conditioned by the fact that initially the process of legal regulation takes place in the conditions of collision of two parties with opposite interests, with one of them taking a stronger position from the socio-economic point of view, and the other party enjoys the priority protection of the state on the basis of its political interests.