bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review of Levitation Control Methods for Low- and Medium-Speed Maglev Systems
Authors: Zhu Qi , Wang Su-Mei , Ni Yi-Qing
Published: March 2024

Maglev transportation is a highly promising form of transportation for the future, primarily due to its friction-free operation, exceptional comfort, and low risk of derailment. Unlike conventional transportation systems, maglev trains operate with no mechanical contact with the track. Maglev trains achieve levitation and guidance using electromagnetic forces controlled by a magnetic levitation control system. Therefore, the magnetic levitation control system is of utmost importance in maintaining the stable operation performance of a maglev train. However, due to the open-loop instability and strong nonlinearity of the control system, designing an active controller with self-adaptive ability poses a substantial challenge. Moreover, various uncertainties exist, including parameter variations and unknown external disturbances, under different operating conditions. Although several review papers on maglev levitation systems and control methods have been published over the last decade, there has been no comprehensive exploration of their modeling and related control technologies. Meanwhile, many review papers have become outdated and no longer reflect the current state-of-the-art research in the field. Therefore, this article aims to summarize the models and control technologies for maglev levitation systems following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) criteria. The control technologies mainly include linear control methods, nonlinear control methods, and artificial intelligence methods. In addition, the article will discuss maglev control in other scenarios, such as vehicle–guideway vibration control and redundancy and fault-tolerant design. First, the widely used maglev levitation system modeling methods are reviewed, including the modeling assumptions. Second, the principle of the control methods and their control performance in maglev levitation systems are presented. Third, the maglev control methods in other scenarios are discussed. Finally, the key issues pertaining to the future direction of maglev levitation control are discussed.
Adaptive Radiotherapy: Next-Generation Radiotherapy
Authors: Dona Lemus Olga Maria , Cao Minsong , Cai Bin , Cummings Michael , Zheng Dandan
Published: March 2024

Radiotherapy, a crucial technique in cancer therapy, has traditionally relied on the premise of largely unchanging patient anatomy during the treatment course and encompassing uncertainties by target margins. This review introduces adaptive radiotherapy (ART), a notable innovation that addresses anatomy changes and optimizes the therapeutic ratio. ART utilizes advanced imaging techniques such as CT, MRI, and PET to modify the treatment plan based on observed anatomical changes and even biological changes during the course of treatment. The narrative review provides a comprehensive guide on ART for healthcare professionals and trainees in radiation oncology and anyone else interested in the topic. The incorporation of artificial intelligence in ART has played a crucial role in improving effectiveness, particularly in contour segmentation, treatment planning, and quality assurance. This has expedited the process to render online ART feasible, lowered the burden for radiation oncology practitioners, and enhanced the precision of dynamically personalized treatment. Current technical and clinical progress on ART is discussed in this review, highlighting the ongoing development of imaging technologies and AI and emphasizing their contribution to enhancing the applicability and effectiveness of ART.
Cumulative Dosage of Intrathecal Chemotherapy Agents Predicts White Matter Integrity in Long-Term Survivors of Acute Lymphoblastic Leukemia: A PETALE Study
Authors: Laniel Julie , Sultan Serge , Sinnett Daniel , Laverdière Caroline , Krajinovic Maja , Robaey Philippe , Duong Luc , Lippé Sarah
Published: March 2024

Acute lymphoblastic leukemia (ALL) stands as the most prevalent form of pediatric cancer in North America, with a current five-year survival rate of 85%. While more children achieved ALL remission and transition into adulthood, the prevalence of long-term treatment-related effects, especially neurocognitive sequelae, remains significant. This study pursues two objectives. Firstly, it investigates if Magnetization Transfer Ratio (MTR), a method assessing myelin integrity, is sensitive to white matter (WM) microstructural changes in long-term ALL survivors and whether these relate to cognitive impairments. Secondly, it examines the dose-related effects of chemotherapy agents on the MTR and its relationship to other risk factors such as female sex, early age diagnosis, and cranial radiotherapy. Magnetization transfer imaging was utilized to assess WM integrity in 35 survivors at a mean of 18.9 years after the onset of ALL (range since diagnosis: 6.9–26.8). Additionally, 21 controls matched for age, sex, and education level, with no history of cancer, were included. MTR was extracted from both the entire brain’s WM and the corpus callosum through semi-automated procedures. The results indicated lower MTR means in survivors, which is linked to cognitive function. Negative associations between MTR means and intrathecal agents’ (MTX, cytarabine, and hydrocortisone) cumulative doses received were highlighted. This study offers valuable insights into the connections between myelin deterioration, cognitive impairment, and the implications of IT chemotherapy, enhancing our understanding of ALL survivorship dynamics. It underscores MTR’s relevance in monitoring neurotoxicity during oncological drug follow-up examinations.
Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications
Authors: Salu Philip , Reindl Katie M.
Published: March 2024

Circulating tumor cells (CTCs) are cells released from the primary and metastatic tumor and intravasate into the blood or lymphatic vessels, where they are transported to distant sites and act as seeds that initiate cancer metastases or the development of further lesions. Recent advances in CTC research have shown their relevance as prognostic markers for early and metastatic disease detection, predictive biomarkers for relapse, and response to medical intervention or therapy. The rapidly evolving landscape of CTC biology has opened new avenues for understanding cancer progression, metastasis, and treatment response. Additionally, translating these findings into clinical applications holds promise for improving cancer diagnostics, prognosis, and personalized therapeutic strategies. This review discusses the significance of CTCs in cancer research and their associated challenges. We explore recent developments in the detection and characterization of CTCs and their implications in cancer research and clinical practice.
Early Results of a Screening Program for Skin Cancer in Liver Transplant Recipients: A Cohort Study
Authors: Akdag Delal , Rasmussen Allan , Nielsen Susanne Dam , Møller Dina Leth , Togsverd-Bo Katrine , Wenande Emily , Haedersdal Merete , Pommergaard Hans-Christian
Published: March 2024

(1) Background: Skin cancer is the most common cancer in transplant recipients. Timely and regular screening may reduce advanced disease. The study aimed to determine referral rates to screening, the incidence, and risk factors of skin cancer in a Danish liver transplant recipient cohort. (2) Methods: All first-time liver transplant recipients, >18 years old, attending outpatient care between January 2018 and December 2021 were included. The referral rates and incidence of skin cancer/preneoplastic lesions were calculated. Risk factors were assessed using Cox regression analyses. (3) Results: Of the 246 included recipients, 219 (89.0%) were referred to screening, and 102 skin cancer/preneoplastic lesions were diagnosed in 32 (15.6%) recipients. The IR of any skin cancer/preneoplastic lesion was 103.2 per 1000 person-years. BCC was the most frequent skin cancer followed by SCC, IR: 51.3 vs. 27.1 per 1000 person-years, respectively. No cases of MM were observed. The IR of actinic keratosis and Bowen’s Disease were 48.1 vs. 13.2 per 1000 person-years, respectively. Time since transplantation was independently associated with skin cancer/preneoplastic lesions, HR (95%CI) 2.81 (1.64–4.80). (4) Conclusions: The study determined the incidence and risk factors of skin cancer/preneoplastic lesions in liver transplant recipients enrolled in a screening program, while demonstrating a high screening referral rate.
Glu-Co-Assisted Iron-Based Metal–Organic Framework-Derived FeCo/N Co-Doped Carbon Material as Efficient Bifunctional Oxygen Electrocatalysts for Zn–Air Batteries
Authors: Sha Pengfei , Yong Xiao , Chen Di , Chen Xing , Yan Fengying , Pang Beili , Dong Hongzhou , Yu Jianhua , Yu Liyan , Dong Lifeng
Published: March 2024

A Zn–air battery serves as an energy storage solution to address fossil energy and environmental concerns. However, sluggish kinetics in oxygen reduction reactions (ORRs) and oxygen evolution reactions (OERs) demand innovative, cost-effective, and stable bifunctional catalysts to replace precious metal catalysts. In this study, an FeCo-CNTs/KB catalyst was synthesized by pyrolyzing NH2-MIL-101(Fe) coated with glu-Co and conductive carbon (KB). This hierarchical structure comprises carbon nanotubes (CNTs) grafted onto a carbon matrix, housing abundant FeCo nanoparticles within the nanotubes or matrix. KB introduction enhances FeCo nanoparticle dispersion and fosters uniform CNT formation with smaller diameters, thus exposing active sites. Consequently, the FeCo-CNTs/KB catalyst exhibits remarkable bifunctional electrocatalytic activity: an ORR half-wave potential of 0.84 V and an OER overpotential of 0.45 V (10 mA cm−2). Furthermore, the FeCo-CNTs/KB catalyst in a secondary Zn–air battery showcases enduring charge–discharge performance (≥300 h).
A Longitudinal Study of the Development of Executive Function and Calibration Accuracy
Authors: Goudas Marios , Samara Evdoxia , Kolovelonis Athanasios
Published: March 2024

This longitudinal study examined the development of executive function and calibration accuracy in preadolescents. This study’s sample consisted of 262 students (127 females) from grades 4 (n = 91), 5 (n = 89), and 6 (n = 82) who took measures of executive function and performance calibration in a sport task three times over 20 months. A latent growth-curve modeling analysis showed a significant relationship between the rates of change of executive function and calibration accuracy. The results also showed a dynamic interplay in the development of executive function and calibration accuracy. There were significant interindividual differences in the estimated population means both in executive function and calibration accuracy and in the rate of change of executive function, but not in the rate of change of calibration accuracy. The age of the participants had a positive effect only on the estimated population mean of executive function.
The Role of Endoscopic Assistance in Surgery for Pediatric Cholesteatoma in Reducing Residual and Recurrent Disease
Authors: Nassif Nader , Redaelli de Zinis Luca Oscar
Published: March 2024

The primary aim of this study was to evaluate long-term recurrent and residual disease after surgery for acquired cholesteatoma in children according to surgical approach. A total of 71 interventions performed on 67 pediatric patients were included in the study. Canal wall-up tympanomastoidectomy (CWUT) was performed in 31 ears (13 with endoscopic assistance), a transcanal esclusive endoscopic approach (TEEA) was used in 22, and canal wall-down tympanomastoidectomy (CWDT) was performed in 18. Overall, the cholesteatoma relapse rate estimated by the Kaplan–Meier method was 47 ± 6% at 12 years; the recurrent cholesteatoma rate was 28 ± 6% and the residual cholesteatoma rate was 26 ± 5%. The relapse rate according to surgical approach was 33 ± 11% for CWDT, 60 ± 9% for CWUT, and 40 ± 11% for TEEA (p = 0.04). The difference for recurrent disease was no recurrent disease for CWDT, 42 ± 9% for CWUT, and 32 ± 11% for TEEA (p = 0.01). The residual disease rate was significantly reduced with endoscopy: 42 ± 8% without endoscopy vs. 9 ± 5% with (p = 0.003). CWDT can still be considered in primary surgery in case of extensive cholesteatomas and small mastoid with poor pneumatization. TEEA can be recommended for small cholesteatoma not extending to the mastoid to reduce morbidity. Endoscopic assistance seems useful to reduce residual disease in CWUT, whereas it does not have a significant impact on preventing recurrent disease.
Mechanical and Tribological Properties of CrWN/MoN Nano-Multilayer Coatings Deposited by Cathodic Arc Ion Plating
Authors: Tian Canxin , Xiang Yanxiong , Zou Changwei , Yu Yunjiang , Abudouwufu Tushagu , Yang Bing , Fu Dejun
Published: March 2024

CrWN/MoN nano-multilayer coatings were deposited in pure N2 by multi-arc ion plating using CrW and Mo targets, with the cathode co-controlled by a permanent magnet combined with an electromagnet. The effects of the thickness modulation period on the microstructure and mechanical and tribological performance were systematically analyzed by grazing-incident X-ray diffraction (GIXRD), transmission electron microscopy (TEM), Nanoindentation, scanning electron microscope (SEM) and profilometry using a Talysurf profilometer. The local coherent interfaces and nanoscale modulation period were confirmed by TEM, while the coatings were confirmed to be composed of fcc-CrWN and hexagonal δ-MoN by GIXRD. With the increase in the modulation period, the hardness of the CrWN/MoN nano-multilayer coatings decreased, and the values of the H/E ratio and friction coefficient showed the same variation trend. At an 8.0 nm modulation period, the CrWN/MoN nano-multilayer coating showed the maximum hardness (30.2 GPa), the lowest H/E value (0.082) and an H3/E*2 value of 0.16. With the decrease in the modulation period, the average friction coefficient of the CrWN/MoN nano-multilayer coatings gradually decreased from 0.45 to 0.29, while the wear rate decreased from 4.2 × 10−7 mm3/Nm to 3.3 × 10−7 mm3/Nm.
Heat of Hydration Analysis and Temperature Field Distribution Study for Super-Long Mass Concrete
Authors: Zhang Sanling , Liu Peng , Liu Lei , Huang Jingxiang , Cheng Xiang , Chen Ying , Chen Lei , He Sasa , Zhang Ning , Yu Zhiwu
Published: March 2024

In this study, the combination of ordinary cement concrete (OCC) and shrinkage-compensating concrete (SCC) was utilized to pour super-long mass concrete. The temperature and strain of the concrete were continuously monitored and managed actively after pouring. The investigation focused on the temporal and spatial distribution patterns of the temperature field, the temperature difference between the core and surface, and the strain evolution. Based on the constructed hydration exothermic model of layered poured concrete, the effects of the SCC, molding temperature, and surface heat transfer coefficient on the temperature field were analyzed. The results show that the temperature of super-long mass concrete rises quickly but falls slowly. SCC exhibits higher total hydration heat than OCC. The temperature field is symmetric along the length but asymmetric along the thickness due to varying efficiency of heat dissipation between the upper and lower parts of the concrete. After final setting of the concrete, the strain varies opposite to the temperature and peaks at −278 με. A few short cracks are observed on the end of the upper surface. Moreover, the numerical simulation results are in good agreement with the measured results. Increasing the molding temperature and surface wind speed increases the temperature difference between the core and surface. Conversely, increasing the thickness of the insulation layer is an effective way to curtail this difference. Thermal stress analysis is carried out and shows that lowering the molding temperature of SCC and increasing the thickness of insulation material can effectively reduce thermal stress.
Exploring Numba and CuPy for GPU-Accelerated Monte Carlo Radiation Transport
Authors: Askar Tair , Yergaliyev Argyn , Shukirgaliyev Bekdaulet , Abdikamalov Ernazar
Published: March 2024

This paper examines the performance of two popular GPU programming platforms, Numba and CuPy, for Monte Carlo radiation transport calculations. We conducted tests involving random number generation and one-dimensional Monte Carlo radiation transport in plane-parallel geometry on three GPU cards: NVIDIA Tesla A100, Tesla V100, and GeForce RTX3080. We compared Numba and CuPy to each other and our CUDA C implementation. The results show that CUDA C, as expected, has the fastest performance and highest energy efficiency, while Numba offers comparable performance when data movement is minimal. While CuPy offers ease of implementation, it performs slower for compute-heavy tasks.
Assessing the Acceptance of Cyborg Technology with a Hedonic Technology Acceptance Model
Authors: de Andrés-Sánchez Jorge , Arias-Oliva Mario , Souto-Romero Mar , Gené-Albesa Jaume
Published: March 2024

Medical implantable technologies, such as cochlear implants or joint prostheses, have been commonly used since the late 20th century. By contrast, the market for this type of technology is expanding when the purpose is not medical, even though it is more marginal. This study tests a technology acceptance model for the latter type of insideable technology based on an extension of the technology acceptance models TAM and TAM2 proposed for hedonic technologies by van del Heijden. So, the behavioral intention of insertables is explained by the perceived usefulness and perceived ease of use, as well as social influence, as proposed in the TAM2 by Venkatesh and Davis. Additionally, the perceived enjoyment, included in the extension by Van der Heijden, is added as an explanatory factor. We applied structural equation modeling to the theoretical scheme provided by the modified TAM and performed a necessary condition analysis. Statistical analysis showed that all variables considered in the model have a significantly positive influence on behavioral intention. Likewise, the model has good properties both from the point of view of the fit obtained, since it predicts 70% of behavioral intention, and from the predictive point of view. The necessary condition analysis allows us to analyze whether the presence of some of the latent variables postulated to explain the attitude toward implantables is necessary to produce the said acceptance. Therefore, its absence is a critical aspect of expansion. We observed that perceived usefulness manifests itself as a necessary condition for behavioral intention with a medium size. Perceived ease of use and enjoyment also present a significant necessity effect size, but their strength is smaller. By contrast, the subjective norm does not have the status of a necessary variable.
A Simple Clinical Scoring System to Determine the Risk of Pancreatic Cancer in the General Population
Authors: Yoshimura Dai , Fukasawa Mitsuharu , Yoda Yoshioki , Ohtaka Masahiko , Ooka Tadao , Takano Shinichi , Kawakami Satoshi , Fukasawa Yoshimitsu , Kuratomi Natsuhiko , Harai Shota , Shimamura Naruki , Hasegawa Hiroyuki , Imagawa Naoto , Suzuki Yuichiro , Yoshida Takashi , Kobayashi Shoji , Sato Mitsuaki , Yamaguchi Tatsuya , Maekawa Shinya , Enomoto Nobuyuki
Published: March 2024

This study aimed to develop and validate a simple scoring system to determine the high-risk group for pancreatic cancer (PC) in the asymptomatic general population. The scoring system was developed using data from PC cases and randomly selected non-PC cases undergoing annual medical checkups between 2008 and 2013. The performance of this score was validated for participants with medical checkups between 2014 and 2016. In the development set, 45 PC cases were diagnosed and 450 non-PC cases were identified. Multivariate analysis showed three changes in clinical data from 1 year before diagnosis as independent risk factors: ΔHbA1c ≥ 0.3%, ΔBMI ≤ −0.5, and ΔLDL ≤ −20 mg/dL. A simple scoring system, incorporating variables and abdominal ultrasound findings, was developed. In the validation set, 36 PC cases were diagnosed over a 3-year period from 32,877 participants. The AUROC curve of the scoring system was 0.925 (95%CI 0.877–0.973). The positive score of early-stage PC cases, including Stage 0 and I cases, was significantly higher than that of non-PC cases (80% vs. 6%, p = 0.001). The simple scoring system effectively narrows down high-risk PC cases in the general population and provides a reasonable approach for early detection of PC.
Recent Insights into the Role of DNA Methylation and Histone Modifications in Systemic Sclerosis: A Scoping Review
Authors: Kostova Tsvetelina , Karalilova Rositsa , Batalov Zguro , Kazakova Maria , Sarafian Victoria , Batalov Anastas
Published: March 2024

Systemic sclerosis is a complex idiopathic disease originating from an intricate interplay between genetic susceptibility, environmental factors, and epigenetic modifications. This scoping review aims to map the advancements made regarding DNA methylation abnormalities and histone modifications in systemic sclerosis in the past decade. A literature search was conducted using three electronic databases (Scopus, Web of Science and PubMed) to identify relevant articles. A total of 44 studies were selected for this review, demonstrating the critical contribution of epigenetic perturbations in multiple cell types to disease pathogenesis. In conclusion, this scoping review has elucidated the significant discoveries made in the past decade regarding the role of DNA methylation and histone modifications in systemic sclerosis. Further progress in the field could lead to the development of novel treatment possibilities targeting epigenetic marks.
Collateral Damage in the Placenta during Viral Infection in Pregnancy: A Possible Mechanism for Vertical Transmission and an Adverse Pregnancy Outcome
Authors: Cruz-Holguín Victor Javier , González-García Luis Didier , Velázquez-Cervantes Manuel Adrián , Arévalo-Romero Haruki , De Jesús-González Luis Adrián , Helguera-Repetto Addy Cecilia , León-Reyes Guadalupe , Salazar Ma. Isabel , Cedillo-Barrón Leticia , León-Juárez Moisés
Published: March 2024

In mammals, the placenta is a connection between a mother and a new developing organism. This tissue has a protective function against some microorganisms, transports nutrients, and exchanges gases and excretory substances between the mother and the fetus. Placental tissue is mainly composed of chorionic villi functional units called trophoblasts (cytotrophoblasts, the syncytiotrophoblast, and extravillous trophoblasts). However, some viruses have developed mechanisms that help them invade the placenta, causing various conditions such as necrosis, poor perfusion, and membrane rupture which, in turn, can impact the development of the fetus and put the mother’s health at risk. In this study, we collected the most relevant information about viral infection during pregnancy which can affect both the mother and the fetus, leading to an increase in the probability of vertical transmission. Knowing these mechanisms could be relevant for new research in the maternal–fetal context and may provide options for new therapeutic targets and biomarkers in fetal prognosis.
Heterogenous Effect of Industrialisation on Environmental Degradation in Southern African Customs Union (SACU) Countries: Quantile Analysis
Authors: Mosikari Teboho
Published: March 2024

Southern African Customs Union (SACU) countries are under pressure to commit themselves to sustainable environmental activities. This study employed data from 2007 to 2021 using quantile regression to determine the heterogenous effects of industrialisation on environmental degradation in SACU countries. Prior to the main results, this study investigated and confirmed the existence of a long-run relationship between industrialisation and environmental degradation. This study confirms the heterogeneous effect of industrialisation on environmental degradation. The results through quantile process estimates demonstrated an inverted U-shaped curve. The inverted U-shape suggests that industrialisation at lower and higher quantiles has a minor effect on the environment compared to medium quantiles, where it has a higher effect. This study found that industrialisation increases environmental degradation in the 4th to 6th quantiles, whereas in the 7th to 8th quantiles, industrialisation reduces environmental degradation. Therefore, it is recommended by this study that to mitigate environmental degradation, firms in SACU countries are encouraged to adopt environment-friendly technologies in their production.
Using Technology-Supported Approaches for the Development of Technical Skills Outside of the Classroom
Authors: McKernon Sarah L. , Adderton Elliot A. , Dawson Luke J.
Published: March 2024

The COVID-19 pandemic, and the subsequent lockdown, had a significant and disproportionate impact on subjects that required the development of clinical technical skills due to the lack of access to simulation classrooms and patients. To directly address this impact, we developed a conceptual framework for the design and implementation of a progressive simulation approach from the perspective of a teacher. This conceptual framework integrates and draws from key theories of simulation design, curriculum integration, learner motivation, and considerations of the facets of good assessment, including modern approach validity. We used the conceptual framework to inform and develop a progressive simulation design to support the development of essential intra-oral suturing skills outside of the classroom, at home, while still being able to provide external feedback as if learners were in the classroom or clinic. Moreover, the approach described significantly extended the available opportunities for deliberate practice, assisting with the automation of essential skills and aiming to better support learner development during face-to-face patient opportunities. Although further work is needed, we believe that our conceptual framework could be applied to any situation where progressive simulation is seen as beneficial, especially if there are elements of key skills that could initially be developed using a simple take-home simulator.
Compact High-Resolution Multi-Wavelength LED Light Source for Eye Stimulation
Authors: Gibertoni Giovanni , Borghi Guido , Rovati Luigi
Published: March 2024

Eye stimulation research plays a critical role in advancing our understanding of visual processing and developing new therapies for visual impairments. Despite its importance, researchers and clinicians still face challenges with the availability of cost-effective, precise, and versatile tools for conducting these studies. Therefore, this study introduces a high-resolution, compact, and budget-friendly multi-wavelength LED light source tailored for precise and versatile eye stimulation, addressing the aforementioned needs in medical research and visual science. Accommodating standard 3 mm or 5 mm package LEDs, the system boasts broad compatibility, while its integration with any microcontroller capable of PWM generation and supporting SPI and UART communication ensures adaptability across diverse applications. Operating at high resolution (18 bits or more) with great linearity, the LED light source offers nuanced control for sophisticated eye stimulation protocols. The simple 3D printable optical design allows the coupling of up to seven different wavelengths while ensuring the cost-effectiveness of the device. The system’s output has been designed to be fiber-coupled with standard SMA connectors to be compatible with most solutions. The proposed implementation significantly undercuts the cost of commercially available solutions, providing a viable, budget-friendly option for advancing eye stimulation research.
A Real-Time Spoofing Detection Method Using Three Low-Cost Antennas in Satellite Navigation
Authors: Chen Jiajia , Wang Xueying , Fang Zhibo , Jiang Cheng , Gao Ming , Xu Ying
Published: March 2024

The vulnerability of civil receivers of the Global Satellite Navigation System (GNSS) to spoofing jamming has raised significant concerns in recent times. Traditional multi-antenna spoofing detection methods are limited in application scenarios and come with high hardware costs. To address this issue, this paper proposes a novel GNSS spoofing detection method utilizing three low-cost collinear antennas. By leveraging the collinearity information of the antennas, this method effectively constrains the observation equation, leading to improved estimation accuracy of the pointing vector. Furthermore, by employing a binary statistical detection model based on the sum of squares (SSE) between the observed value and the estimated value of the pointing vector, real-time spoofing signal detection is enabled. Simulation results confirm the efficacy of the proposed statistical model, with the error of the skewness coefficient not exceeding 0.026. Experimental results further demonstrate that the collinear antenna-based method reduces the standard deviation of the angle deviation of the pointing vector by over 55.62% in the presence of spoofing signals. Moreover, the experiments indicate that with a 1 m baseline, this method achieves 100% spoofing detection.
Secure Change Control for Supply Chain Systems via Dynamic Event Triggered Using Reinforcement Learning under DoS Attacks
Authors: Fan Lingling , Zhang Bolin , Xiong Shuangshuang , Li Qingkui
Published: March 2024

In this paper, a distributed secure change control scheme for supply chain systems is presented under denial-of-service (DoS) attacks. To eliminate the effect of DoS attacks on supply chain systems, a secure change compensation is designed. A distributed policy iteration method is established to approximate the coupled Hamilton–Jacobi–Isaacs (HJI) equations. Based on the established reinforce–critic–actor (RCA) structure using reinforcement learning (RL), the reinforced signals, performance indicators, and disturbance input are proposed to update the traditional time-triggered mechanism, and the control input is proposed to update the dynamic event-triggered mechanism (DETM). Stability is guaranteed based on the Lyapunov method under secure change control. The simulation results for supply chain systems show the effectiveness of the secure change control scheme and verify the results.
Drought Differently Modifies Tolerance and Metal Uptake in Zn- or Cu-Treated Male and Female Salix × fragilis L.
Authors: Drzewiecka Kinga , Gąsecka Monika , Magdziak Zuzanna , Rybak Michał , Budzyńska Sylwia , Rutkowski Paweł , Niedzielski Przemysław , Mleczek Mirosław
Published: March 2024

The aim of this study was to determine the tolerance to metals (Zn, Cu) and drought of male and female Salix × fragilis L. under isolated and combined treatments, and to assess the metal uptake and profiling of metabolic plant responses. The 14-day experiment was performed in a hydroponic system, and metals were applied at 1.5 mM in a Knop’s solution. Drought simulation was achieved by adding sorbitol at a moderate level (200 mM). Isolated Zn treatment enhanced plant growth, more pronouncedly in females. Equimolar Cu treatment caused diverse reactions, and females exhibited significantly higher tolerance. Male specimens were less tolerant to isolated drought and to combined drought and metal presence. The highest contents of Cu and Zn were found in roots, compared to the aboveground tissues (wooden rods and leaves), of both female and male metal-treated plants. Simultaneously applied drought limited Zn accumulation in roots and elevated its translocation to leaves while increasing Cu accumulation, predominantly in females showing higher tolerance. Both isolated and combined drought and metals reduced leaf water content, caused the allocation of mineral nutrients (Ca, Mg, K, and Na), and affected metabolism in a stressor-specific and sex-dependent manner. For males, Cu accumulation in the leaves was significantly correlated with the majority of metabolites, while for both sexes, kaempferol and salicylic acid were strongly correlated, indicating their role in tolerance against the metal. The obtained results are an excellent starting point for the practical use of male and female Salix × fragilis L. in areas heavily polluted with Cu or Zn and exposed to drought, for the purpose of their recultivation.
Sustainable Forest Development in the Digital Era: The Impact of Internet Use on the Happiness of Forest Farmers’ Families in Ecologically Fragile Ethnic Areas of China
Authors: Zhao Xin , Zhang Ke , Zhao Rong
Published: March 2024

In the policy arena of the rapid development of China’s digital village, understanding how internet use enhances the happiness of forest farmers’ families holds theoretical and practical significance for promoting the protection of the ecological environment and the sustainable development of forests. This study utilizes survey data from 2023 on forest farmers in ecologically fragile ethnic areas in China. Based on sustainability, a five-dimensional evaluation index system for the happiness of forest farmers’ families has been constructed. First, the CRITIC-TOPSIS model is employed to calculate the happiness scores of forest farming households. Subsequently, the Tobit model and the mediation effect model are applied to examine and analyze the influencing factors and mechanisms of internet usage on the happiness of forest farmers’ families. The study finds that, first, an increase of one unit in terms of internet use is associated with a 0.031-unit increase in the happiness of forest farmers’ families, and that education, social perception, and policy perception all have a positive effect on the happiness of forest farmers’ families. Second, the mechanism of action suggests that internet use significantly increases forest farmers’ families’ happiness through subjective class identity. Third, further heterogeneity analyses revealed that internet use contributed to the happiness of forest farmers’ families in the male group, the low human capital group, and the group with an ecological forest ranger in the family. Therefore, it is necessary to strengthen the construction of digital rural infrastructure and develop new models such as digital forestry; cultivate and introduce specialized digital talents in rural areas and enhance the digital literacy of forestry farmers; and assist forestry farmers in establishing class identity concepts and social values conducive to the sustainable development of forests and implement ecological values in production practices, thereby improving the happiness of forest farmers’ families.
Rapid Warming Exacerbates Winter Drought Stress in Trees at High-Altitude Areas in Northeast China
Authors: Zhang Rui , Bai Xueping , Tian Xun , Chen Zhenju , Zhang Haiyue , Liu Haiting
Published: March 2024

Against the background of global warming, trees in high-latitude and high-altitude areas are more sensitive to rapid warming. Revealing the response patterns of trees at different altitudes to rapid warming in typical alpine mountain environments can help to predict the future distribution of forests in the region and the associated changes in the timberline. This study used tree-ring width data (band sampling) from Dahurian larch (Larix gmelinii Rupr.) along an altitudinal gradient (970–1409 m) on Oakley Mountain to establish 10 chronologies and to analyze the growth–climate response of larch to warming and altitudinal changes along a gradient. The results showed that before rapid warming, larch growth was strongly influenced mainly by precipitation in July–August, while after warming, the growth was controlled mainly by precipitation (snowfall) in winter (October–April) and showed a significant positive correlation with the SPEI in winter and a negative correlation with temperature in February–April (early spring). This indicates that the rapid warming event led to a drastic change in the water heat balance during the pre-growth period of the trees in the study area, which shifted the tree growth from being restricted by drought in the growing season before warming to being restricted by winter drought (i.e., the lagged effect of snowfall in the pre-growing season) after warming and that the trees at low altitudes suffered from more severe winter drought. In the future, as the global climate warms further, the growth of mountain larch at low altitudes (below 1200 m) will continue to decrease, and the coupling of winter snowfall and seasonal (February–April) warming will increase the upper altitude limit at which winter drought occurs for larch in the study area; additionally, larch at higher altitudes will be able to cope with this ecological process better.
Terpene Compound Composition and Antioxidant Activity of Essential Oils from Needles of Pinus densiflora, Pinus koraiensis, Abies holophylla, and Juniperus chinensis by Harvest Period
Authors: Kim Eunjin , Yang Suyeon , Jeon Byeong Bae , Song Eugene , Lee Hwayong
Published: March 2024

Plant resources are used as raw materials in various industries related to humans, such as edible, medicinal, taste, and flavor industries, depending on processes such as drying, processing, and collection period. In this study, we investigated the terpene compound composition and antioxidant activity of essential oils extracted from the needles of Pinus densiflora, Pinus koraiensis, Abies holophylla, and Juniperus chinensis collected in the harvest period (February, April, July, and October) planted on the campus of Chungbuk National University. The essential oil was separated by hydrodistillation. According to the analysis results of gas chromatography–mass spectrometry, the terpene compounds changed depending on the season and tree species. The proportions of monoterpene and sesquiterpene classes in the needles of P. densiflora, P. koraiensis, A. holophylla, and J. chinensis changed depending on the harvest period. The antioxidant activity by DPPH and ABTS assays varied depending on the species and seasons, and needles harvested from P. koraiensis showed the highest activity in all harvest periods. High antioxidant activity has been confirmed even at low concentrations in pine trees, so it is expected to play a role as a natural antioxidant. Additionally, since the composition of terpene compounds varies depending on the harvesting time and species, it is expected to have various uses in the pharmaceutical, cosmetics, and food industries.
Polygonatum sibiricum Saponin Prevents Immune Dysfunction and Strengthens Intestinal Mucosal Barrier Function in Cyclophosphamide-Induced Immunosuppressed BALB/c Mice
Authors: Zhao Dongyun , Liu Huanhuan , Yan Chunhong , Teng Yue , Zou Yue , Ren Xiaomeng , Xia Xiaodong
Published: March 2024

The aim of this study was to explore the immunomodulatory effect of Polygonatum sibiricum saponin (PS) in a cyclophosphamide-induced (Cy) immunosuppression mice model. Oral administration of PS by gavage effectively alleviated weight loss caused by Cy and increased the index of immune organs. PS promoted the proliferation of splenic lymphocytes and T cell subsets (CD3+, CD355+, CD4+/CD8+) and relieved the xylene-induced inflammatory response and Cy-induced increase of serum hemolysin. Moreover, PS increased serum levels of lactate dehydrogenase and acid phosphatase. PS elevated serum level of cytokines and immunoglobulins (TNF-α, IFN-γ, IL-4, IL-6, IL-β, SIgA, and IgG) and the expression of mRNA of IL-10, TNF-α, and IL-6 in the spleen. Increased mRNA expression of tight junction protein (ZO-1, Mucin2, Occludin) expression and protein expression of IL-6/MyD88/TLR4 in the small intestine showed that PS exhibited a restorative effect on intestinal mucosal injury caused by cyclophosphamide. Oral PS prevented Cy-induced decline in leukocytes, red blood cells, lymphocytes, hemoglobin concentrations, and neutrophils, providing evidence for alleviating hematopoietic disorders. In addition, PS increased SOD and NO levels, reduced MDA levels, and improved oxidative damage in the liver. These findings demonstrate that PS has the potential to be developed as a supplemental agent for alleviating immunosuppression caused by chemotherapeutic agents.
Utilizing Xanthan Gum Coatings as Probiotic Bacteria Carriers to Enhance Postharvest Quality and Antioxidants in Fresh-Cut Cantaloupe and Honeydew (Cucumis melo L.) Melons
Authors: Chikhala Tshudufhadzo , Seke Faith , Slabbert Retha M. , Sultanbawa Yasmina , Sivakumar Dharini
Published: March 2024

Due to spoilage microflora and browning, minimally processed fresh-cut fruits have a short shelf life, and over the years, studies have shown the potential of using edible coatings to extend the shelf life and improve the safety of fresh-cut fruits. Recently, there has been a rise in research on the incorporation of probiotics in edible coatings due to the bespoke health and biopreservation benefits they impart. Therefore, in this study, lactobacillus strains (Lactiplantibacillus plantarum 75 and Bifidobacterium longum) were incorporated into a xanthan edible coating to enhance color retention, sensory properties, antioxidant retention (ascorbic acid, carotenoids, total phenols), and antioxidant activity (FRAP antioxidant power, ABTS scavenger activity) of fresh-cut cantaloupes and honeydew cucumis melo L. melons during cold storage at 5 C and 85% RH for five days. The edible coating was prepared by mixing 0.5% xanthan gum, 1% glycerol, and 2% citric acid solution with L. plantarum 75 (LAB 75) and Bifidobacterium longum bacteria separately, and the final lab count for each strain was made to be 8.0 log CFU/mL. Stable probiotic coatings with ζ-potential of between −39.7 and −51.4 mV and a PdI of 1 were developed, and the incorporation of the probiotic bacteria into the coating was justified using FTIR analysis. The probiotic coatings showed a typical pseudoplastic behavior, in which the viscosity curves fall as the shear rate increases. Thermal stability analysis showed a continuous and multi-step weight reduction in this work, illustrating how the edible coating components interact. The survival of both Lactobacillus strains was recorded on day 5. Both freshly cut melons coated with xanthan and loaded with Lactobacillus strains retained a sufficient quantity of probiotics at the end of storage, while L. plantarum 75 (7 log CFU/g for cantaloupe and 8 log CFU/g for honeydew) retained the highest viability compared to B. longum (6 log CFU/g for cantaloupe and 7 log CFU/g for honeydew). In comparison to the coated and uncoated control samples, the inclusion of L. plantarum 75 in xanthan coatings significantly retained the color properties, pigments (total chlorophyll and carotenoids), ascorbic acid, total phenols, and antioxidant activity (FRAP, DPPH, and ABTS). The overall acceptability of fresh cuts of cantaloupe and honeydew melons coated with xanthan gum loaded with L. plantarum 75 was higher than that of other treatments. Thus, xanthan gum loaded with L. plantarum 75 coating is most suitable for reducing postharvest losses in fresh cuts of honeydew melons and cantaloupe, which will help preserve antioxidant and bioactive properties. The xanthan gum loaded with L. plantarum 75 coatings exhibited the highest preservation impact; therefore, it can be recommended for the fresh-cut industry.
Effect of UV-C Treatment on Shelf Life of Soft Wheat Bread (Bun)
Authors: Romano Rita Chiara , Restuccia Cristina , Rutigliano Chiara Alessandra Carmen , Spartà Santi , Parafati Lucia , Barbagallo Riccardo N. , Muratore Giuseppe
Published: March 2024

The effect of exposure of soft wheat buns to Ultraviolet-C radiation (UV-C, 253.7 nm) was studied as an alternative to conventional treatments to control fungal spoilage and prolong shelf life. To identify the most suitable operating conditions, the study included preliminary tests on the permeability of films to UV-C irradiation, and on treatment antifungal efficacy on target microorganisms (Penicillium digitatum and Saccharomycopsis fibuligera) in Petri dishes. A 125 µm T9250B film (Cryovac® Sealed Air S.r.l), commercially available for long-life bread treated with ethanol and conditioned in a modified atmosphere, was selected to pack buns before the UV-C treatment. The study was carried out along with the observation of the fungal growth of buns artificially inoculated with suspensions of P. digitatum and S. fibuligera, treated under UV-C at a distance of 25 cm between bread and the 15 W UV-C source, in comparison to untreated buns used as control. Estimation of fungal growth as well as sensory evaluation was made 2, 4, 7, 10 and 14 days after the treatment. UV-C treated buns showed a noticeable reduction of fungal spoilage and kept a tender texture for up to two weeks after packaging. UV-C treatment represents a good opportunity for the bakery industry, reducing costs and ensuring a prolonged shelf life of a commercial product, respecting the health and hedonistic expectations of the customers.
The Soliton Solutions for Nonlocal Multi-Component Higher-Order Gerdjikov–Ivanov Equation via Riemann–Hilbert Problem
Authors: Liu Jinshan , Dong Huanhe , Fang Yong , Zhang Yong
Published: March 2024

The Lax pairs of the higher-order Gerdjikov–Ivanov (HOGI) equation are extended to the multi-component formula. Then, we first derive four different types of nonlocal group reductions to this new system. To construct the solution of these four nonlocal equations, we utilize the Riemann–Hilbert method. Compared to the local HOGI equation, the solutions of nonlocal equations not only depend on the local spatial and time variables, but also the nonlocal variables. To exhibit the dynamic behavior, we consider the reverse-spacetime multi-component HOGI equation and its Riemann–Hilbert problem. When the Riemann–Hilbert problem is regular, the integral form solution can be given. Conversely, the exact solutions can be obtained explicitly. Finally, as concrete examples, the periodic solutions of the two-component nonlocal HOGI equation are given, which is different from the local equation.
Genome-Wide Association Analysis of Semen Characteristics in Piétrain Boars
Authors: Reyer Henry , Abou-Soliman Ibrahim , Schulze Martin , Henne Hubert , Reinsch Norbert , Schoen Jennifer , Wimmers Klaus
Published: March 2024

Since artificial insemination is common practice in pig breeding, the quality and persistence of the semen are decisive for the usability of individual boars. In the current study, genome-wide association analyses were performed to investigate the genetic variability underlying phenotypic variations in semen characteristics. These traits comprise sperm morphology and sperm motility under different temporal and thermal storage conditions, in addition to standard semen quality parameters. Two consecutive samples of the fourth and fifth ejaculates from the same boar were comprehensively analyzed in a genotyped Piétrain boar population. A total of 13 genomic regions on different chromosomes were identified that contain single-nucleotide polymorphisms significantly associated with these traits. Subsequent analysis of the genomic regions revealed candidate genes described to be involved in spermatogenesis, such as FOXL3, GPER1, PDGFA, PRKAR1B, SNRK, SUN1, and TSPO, and sperm motility, including ARRDC4, CEP78, DNAAF5, and GPER1. Some of these genes were also associated with male fertility or infertility in mammals (e.g., CEP78, GPER1). The analyses based on these laboriously determined and valuable phenotypes contribute to a better understanding of the genetic background of male fertility traits in pigs and could prospectively contribute to the improvement of sperm quality through breeding approaches.