bluuebunny/crossref_metadata_2025 huggingface dataset:
Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
Authors: Ikeda Yuka , Taniguchi Kurumi , Nagase Nozomi , Tsuji Ai , Kitagishi Yasuko , Matsuda Satoru
Published: October 2021

Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS are even necessary to support cellular functions as a second messenger for homeostasis under physiological conditions. Therefore, redox medicine could develop as a new therapeutic concept for human health-benefits. Here, we introduce the involvement of ROS on the crossroads of stemness, senescence, and carcinogenesis in a stem cell and cancer cell biology. Amazingly, the anti-proliferative (APRO) family anti-proliferative proteins characterized by immediate early growth responsive genes may also be involved in the crossroads machinery. The biological functions of APRO proteins (APROs) seem to be quite intricate, however, which might be a key modulator of microRNAs (miRNAs). Given the crucial roles of ROS and APROs for pathophysiological functions, upcoming novel therapeutics should include vigilant modulation of the redox state. Next generation of medicine including regenerative medicine and/or cancer therapy will likely comprise strategies for altering the redox environment with the APROs via the modulation of miRNAs as well as with the regulation of ROS of cells in a sustainable manner.
Petru Poni - a Model of Leadership, Integrity and Tenacity
Authors: Cristea Mariana , Ionita Daniela , Simionescu Bogdan C.
Published: October 2021

The article recalls the big personality of Petru Poni, one of the Romanian pioneers of the research in chemistry. The evocation is realized from the perspective of his contribution in the development of education in the second part of the 19th century as it is reflected mainly in his memoirs �What I wanted to do�. The achievement of the objectives of his life did not have a smooth path. However, his willingness to learn, the choice of action instead of resemnation and the purpose to do something meaningful in his life brought him to accomplishment.
Speciation of Dissolved Ferrous and Ferric Iron in Catamarasti Lake, Botosani (Romania)
Authors: Gavriloaiei Traian , Luchian Elena
Published: October 2021

The aquatic chemistry of iron involves many environmental aspects because dissolved iron is present as ferrous and ferric ion and the equilibrium between these two forms depends on many natural or antropogenic factors. This paper aims to provide a brief introduction to chemistry of iron in an oligotrophic lake, a new topic in this domain. A number of 28 sampling were taken from Catamarasti Lake, Botosani (Romania). The main physico-chemical properties showed that the acidity, dissolved oxygen, electrical conductivity and saturation satisfied the water quality criteria for this ecosystem. The results for dissolved iron species indicated that there is no strictly correlation with the variation of oxygen content. Thus, for the samples from NE shore, the contents of ferrous iron are bigger than of ferric iron, for the samples from SW shore the contents are almost equal, because of the low contents of oxygen. For the samples from the middle and from downstream of the lake, the contents of ferric iron are bigger than of ferrous iron, due to the oxygen content recorded.
Sensitivity Analysis of Post Combustion Carbon Capture Using Monoethanolamine (MEA) as a Solvent. A Simulation Study
Authors: Hassan Ahmad , Ali Usman
Published: October 2021

Carbon capturing and storage (CCS) is new technology to remove CO2 from the processes that involve elimination of CO2 as its effect on the environment and incessant increase in temperature of the Earth, makes it interesting as well as most dangerous issue that should be dealt timely to reduce the greenhouse gas emissions. In the present research, the data obtained from the experimental study of CO2 capture pilot plant at the Laboratory of Engineering Thermodynamic in TU Kaiserslautern, Germany, is used for the rate based model validation for different cases using monoethenolamine (MEA) as a solvent. Process simulation sensitivity analysis performed includes a wide range of CO2 concentrations for flue gas of different sources i.e. natural gas fired power plant, exhaust gas recycle and coal based power plant. Results obtained from sensitivity analysis point out the effects of lean loading, stripper pressure, MEA concentration and CO2 concentration in flue gas on energy requirement of reboiler and degree of regeneration using MEA as a solvent for a pilot-scale study. It was found that the specific reboiler duty is least for coal-fired power plant in comparison to the natural gas �fired and exhaust gas recycled power plant, keeping the flow rate of the flue gas constant.
Chemical Composition and Antimicrobial Activity of Ethanolic Bark and Leave Extract of Zanthoxylum Caribaeum Lam. from Norte de Santander, Colombia
Authors: Ortega-Buitrago Oscar , Chaves-Bedoya Giovanni , Ortiz-Rojas Luz Yineth
Published: October 2021

Interest in the study of bioactive molecules present in plant organs such as root, leaves, stems or flowers, has increased significantly in search of applications in fields such as medicine and agriculture, mainly due to the bactericidal, antifungal and insecticides properties found in different plant species. In this study, leaf and bark extracts obtained at reduced pressure of Z. caribaeum were evaluated for their antibacterial and antifungal activity using the Kirby-Bauer agar disk diffusion technique. We found that extracts from the bark of this tree show a greater biological activity compared to extracts obtained from leaf, mainly against Grampositive bacteria such as S. aureus and S. mutans. However, there was no significant biological activity against gram-negative bacteria such as E. coli or Morganella sp. The composition of the extract determined by gas chromatography coupled to mass spectrophotometry (GC-MS), reveal the presence of the compound 3.5-dihydroxy-6-methyl-2.3-dihydro-4H-piran-one (32.8%) as a majority compound, which has been reported with antibacterial properties. The biological activity of the extracts of Z. caribeaum represents a potential source for the development of drugs for the control of microbial diseases.
A GPA, vagyis a Kormányzati Beszerzési megállapodás
Authors: Kenessey Réka
Published: October 2021

A cikk a GPA-val foglalkozik, ismertetve annak történeti előzményeit, főbb rendelkezéseit, kiemelten vizsgálva a hatállyal kapcsolatos rendelkezéseket. A cikk kitér a GPA viszonylatában a nemzeti elbánás alapelve érvényesülésének egyes kérdéseire is.
Nuclear terrorism: Assessment of the danger of Nuclear Power Plant air strikes
Authors: Metelkov A.
Published: October 2021

The article analyzes the problem of possible threats with the use of aircraft captured by terrorists or controlled unmanned aerial vehicles in relation to nuclear energy use facilities. In the context of preventing acts of nuclear terrorism, the urgent task is to protect nuclear facilities from deliberate attacks by civilian airliners operated by terrorists. On the basis of the materials of publications, the influence of external extreme loads acting on the design of nuclear power plants, their features during the fall of aircraft of different types is studied. As a conclusion, the author notes that improving the safety of nuclear power plants and other radiation-hazardous facilities, minimizing possible consequences from aircraft strikes are important areas in risk management and their protection from acts of nuclear terrorism by combining organizational measures to combat terrorism and nuclear security measures.
Without scientific discussion, the rise in food prices and hunger cannot be stopped
Authors: Tarkhanov O
Published: October 2021

Based on the analysis of the works of Boussengo, the article shows that the results of the French scientist's research do not reveal the essence of the mechanism of plant nutrition in nature, and his opinion about the possibility of producing artificial chemical fertilizers in order to obtain sustainable crop yields is a cautious hypothesis.

The basis of the agrochemical direction in agriculture in the USSR is Liebig's theory of mineral nutrition of plants. This theory, implemented in practice, was the main reason for the death of the USSR and is the cause of the difficult state of the world agricultural food production industry, which is expressed in the continuous increase in food prices.

Additional grounds have been obtained for the exceptional importance of institutional measures to overcome misconceptions in the agricultural and related sciences through the adoption of a provision on scientific discussion, without which food production will only decrease, bringing the threat of famine closer to the Third World War for fertile land.
Digitalisierung von Montageprozessen/Determination of potentials for the integration of assembly services into dynamic platforms
Authors: Dümmel Johannes , Eger Larissa
Published: October 2021

Aktuelle Forschung zeigt das Potenzial von Produktionsplattformen im B2B-Bereich [1]. Durch die Betrachtung ganzheitlicher Lieferketten werden neben den Produktions- auch Montage- und Transportkapazitäten integriert. Für die Sicherstellung der Montagequalität innerhalb der Prozesse kommen Technologien wie Montageassistenzsysteme (Assembly Assistance Systems, AAS) zum Einsatz. Dieser Beitrag definiert Anforderungen an AAS für deren Integration in Produktionsplattformen und leitet Handlungsempfehlungen ab.

 

Current research shows the potential of production platforms in the B2B sector [1]. Cross-company supply chains combine assembly and transport capacities with production capacities. Technologies such as Assembly Assistance Systems (AAS) can be used to ensure assembly quality within the processes. This article defines requirements for AAS for their integration into production platforms and defines recommendations.
Ein semiaktiver Ansatz zur Verbesserung des dynamischen Verhaltens/Vibration damping on industrial robots – A semi-active approach to improve the dynamic behavior
Authors: Neubauer Michael , Mesmer Patrick , Lechler Armin , Verl Alexander
Published: October 2021

Von Industrierobotern wird zunehmend eine hohe Bahn genauigkeit und ein gutes Störunterdrückungsverhalten gefordert. Um dem gerecht zu werden, wird hier ein semiaktiver Dämpfungsansatz vorgestellt, der Antriebsstrangschwingungen aktorbasiert dämpft. Damit geht ein stärker gedämpftes Systemverhalten einher, wodurch sich die Regelverstärkungsfaktoren erhöhen lassen. Das Resultat ist ein verbessertes Gesamtverhalten, das an einem „Kr210–2“ von Kuka mit semiaktiver Dämpfung an Achse 1 nachgewiesen wird.

 

Industrial robots are increasingly required to provide high path accuracy and good disturbance rejection behavior. In order to achieve this, a semi-active damping approach is presented, which damps drive train vibrations actuator-based. This leads to a more damped system behavior, allowing control gains to be increased. The result is an improved overall behavior, which is demonstrated on a Kuka Kr210–2 with semi-active damping on axis 1.
Digitalisierung von additiven Fertigungseinheiten/Digitalization of additive manufacturing units
Authors: Vogt Maximilian , Weber Julian Ulrich , Prakash Vishnuu Jothi
Published: October 2021

Additive Fertigungstechnologien erlauben die bedarfsgerechte Produktion von individuellen Ersatzteilen. Durch Einsatz mobiler Fertigungseinheiten lässt sich mithilfe dieser Verfahren die Resilienz von isolierten Produktionsstätten erhöhen. Um auch außerfachliches Personal zur Bedienung an entlegenen Einsatzorten zu befähigen, stellen digitale Assistenzsysteme eine mögliche Lösung dar. In diesem Beitrag wird ein solches Assistenzsystem zur Begleitung der manuellen Tätigkeiten beim roboterbasierten DED-Prozess in einer mobilen Fertigungseinheit diskutiert.

 

Additive manufacturing technologies enable the demand-driven production of individual spare parts. By using mobile manufacturing units, these processes can be used to increase the resilience of isolated production sites. In order to enable non-specialized personnel to operate at remote locations, digital assistance systems are a feasible solution. This paper discusses such an assistance system to accompany manual operations of the robot-based DED process in a mobile manufacturing unit.
Automatisierung in der industriellen Endoskopie/Development of new means regarding sensor positioning and measurement data evaluation – Automation of Industrial Endoscopy
Authors: Bath Lukas , Schmedemann Ole , Schüppstuhl Thorsten
Published: October 2021

Die speziell zur Inspektion von Kavitäten eingesetzte industrielle Endoskopie ist im Gegensatz zu anderen zerstörungsfreien Prüfverfahren bisher wenig automatisiert. Dies liegt größtenteils an der anspruchsvollen Handhabung der Geräte innerhalb schwer zugänglicher Bereiche sowie der komplexen Auswertung der aufgenommen Messdaten aufgrund hochvarianter Aufnahmebedingungen. In diesem Beitrag wird ein neuartiger Kontinuumsroboter vorgestellt, der die kontaktfreie Führung des Sondenkopfs auf einer Kreisbahn erlaubt und so reproduzierbarere und bessere Sichtbedingungen schafft. Zusätzlich wird ein Konzept zur automatisierten Messdatenauswertung basierend auf Deep Learning vorgestellt.

 

In contrast to other non-destructive testing methods, industrial endoscopy, which is used specifically for inspecting cavities, has so far been little automated. This is largely due to the demanding handling of the devices within areas that are difficult to access as well as the complex evaluation of the recorded measurement data due to highly variant recording conditions. In this paper, a novel continuum robot is presented that enables non-contact guidance of the probe head on a circular path, creating more reproducible and improved viewing conditions. Additionally, a concept for automated measurement data analysis based on Deep Learning is presented.
TĂNG CƯỜNG SỰ THAM GIA CỦA PHỤ NỮ TRONG LĨNH VỰC CHÍNH TRỊ - GIẢI PHÁP THÚC ĐẨY BÌNH ĐẲNG GIỚI
Authors: Dương Kim Anh
Published: October 2021

Thúc đẩy sự tham gia của phụ nữ trong lĩnh vực chính trị là vấn đề cốt lõi gắn liền với sự thịnh vượng và phát triển bền vững của mỗi quốc gia. Sự tham gia của phụ nữ trong lĩnh vực chính trị không chỉ giúp cá nhân phụ nữ phát triển, mà còn tạo đà phát triển cho gia đình, cộng đồng và quốc gia. Bên cạnh đó, sự tham gia của phụ nữ trong lĩnh vực chính trị tăng cường tiếng nói, vai trò đại diện, quyền ra quyết định của phụ nữ, thúc đẩy bình đẳng giới và tiến bộ xã hội. Bài viết nhấn mạnh yêu cầu thúc đẩy phụ nữ tham chính trên bình diện quốc tế và quốc gia; tầm quan trọng của phụ nữ tham chính; phân tích các cơ hội, thách thức đối với phụ nữ tham chính. Bài viết cũng đưa ra các giải pháp thúc đẩy sự tham gia của phụ nữ trong lĩnh vực chính trị, tăng cường tỷ lệ phụ nữ tham chính ở Việt Nam, trong đó có một số giải pháp đối với Hội LHPN Việt Nam - tổ chức chính trị xã hội quan trọng trong chăm lo, bảo vệ quyền và lợi ích hợp pháp của phụ nữ.
POSTFEMINISM
Authors: LICHEVA Amelia
Published: October 2021

In the age of all "post" and "meta" things, when there has been more and more debates about the death of traditional categories, feminism makes no exception. Postfeminism has been discussed since the last decade of the twentieth century, when feminism was pronounced dead (by analogy with the many deaths that were pronounced in the period), or else it was noted as suffering from an "identity crisis." The multifaceted nature of the term depends on its uses in literary studies, academia, politics, and popular culture, respectively. It is part of the vocabulary and theories of feminist scholars working in the fields of gender studies, film studies and media criticism. Traditional feminism gives way to postfeminism. That is why the article deals with today's debates about the distinctions that postfeminism makes, declaring either that traditional feminism has failed or, on the contrary, that it has achieved all goals of its struggle and today there is no place for the topic of women's rights. The text also
focuses on the links between postfeminism and popular culture, media, cinema, defending the ideology of successful women, of eternally young women. With its frequent emphasis on luxurious lifestyle, everyday pleasures and the small things in life, postfeminism is fully integrated into economic discourses and new market niches in Western societies.
THE USE OF STANDARD ALBANIAN LANGUAGE BY PRIMARY SCHOOL TEACHERS
Authors: PLLANA ELEZI Violeta
Published: October 2021

This paper investigates the level of standard Albanian use by primary school teachers for grades 1-5 in Kosovo as well as in the cities of Presheva and Bujanoc in Serbia. This paper investigates concrete situations and problems of standard Albanian and other varieties use in school. The research was conducted with a total number of 66 teachers in the form of a questionnaire and test on concrete problems of standard Albanian spelling norm. In order to have an example of a fourdimensional space, information on sociolinguistic factors, such as: work experience, region of origin, education, and gender of respondents were collected intentionally as important dimensions for a language. The research is of a descriptive nature and does not intend to provide assessments of a prescriptive nature nor take a stance on the investigated cases. Instead, in a more complete way, through the survey corpus, it intends to process the data statistically and present the current situation of standard Albanian use
in its written form by primary school teachers. According to the research results, standard Albanian is not well mastered by the primary school teachers in Kosovo. However, based on the research results, in school we have a diglossic situation of different varieties use: standard Albanian, literary Gheg, dialectical (local) Gheg, which coexist depending on the situations of formal and informal communication that can occur in school, although in this domain of formal communication it is the high variety that is intended to be used.
THE COLOR TERMS FOR BLACK AND WHITE IN BULGARIAN, POLISH AND LITHUANIAN PHRASEOLOGICAL UNITS
Authors: IVOVA Nadelina
Published: October 2021

The present paper is contrastive analysis of Bulgarian, Polish and Lithuanian phraseological units containing a color term naming black or white. It traces the way these components reflect the figurative meaning of the unit - through their color semantics or through their function as a cultural signs. The study classiffiеs Bulgarian, Polish and Lithuanian expressions as to their belongings to several groups, which refer to different concepts. In each group the comparison of the examples found in the three phraseological subsystems is based on their semantics, their lexical components and
structure. Under observations are substantive, adjectival, adverbial and verbal phraseological units where the colors are used only as an adjective component. The analysis takes into consideration that black has negative symbolism and cultural
connotations. Thus the phraseological units with black are linked mainly to the concepts such as death, sorrow, bad life, misfortune. The text suggests that color term for black is rarely used to express neutral or positive meanings. The white has a
positive cultural connotation associated to whiteness, light, good life, goodness, but its meaning can vary to neutral or negative in phraseological system of the three languages. The present paper observes similarities of collected phraseological expressions and emphasizes their nation-specific features.
POSTFEMİNİZMİN CEZA MAHKEMELERİNE SOSYAL MEDYA İLE MÜDAHALESİ
Authors: ÖNDER Mehmet Seyman
Published: October 2021

Toplumsal cinsiyet eşitliğinin sağlanması hedefiyle ortaya çıkan feminist hareket, 1970’lerden itibaren medyanın verdiği güçle ceza hukukuna müdahale ve etmiş kadınların lehine bazı değişikliklerin olmasını sağlamıştır. 2010’lu yıllardan itibaren sosyal medyanın gücünü keşfetmiş ve ceza mahkemelerine müdahale etmeye başlamıştır. Türkiye’de de sosyal medyanın gücünü etkin bir şekilde kullanan feministler, kadına şiddet ve kadın cinayetleri vakalarının bazılarını kamuoyunun gündemine getirmiş ve yargı kararlarına müdahale etmiştir. Bu çalışmada da feminist grupların, bazı davalar üzerine yargıyı nasıl etkilediği ve bunun olası risklerinin neler olabileceği konusu tartışılmıştır. Kamuoyunun gündeminde uzun süre yer edinen vakaların tespiti için en çok takip edilen haber sitelerinin 6’sında 292 haber linki taranmıştır. Ayrıca, ilgili vakalar hakkında açılan hashtaglere atılan tweetler taranmış, en çok ve etkili tweet atan 23 kadın örgütü hesabı, bunların takipçi sayıları (831.101) ve davaların hangi sürecinde tweetler atıldığı ve hashtagler açıldığı belirlenmiştir
SALTED CHEESE PRODUCTION TECHNOLOGY AND ITS QUALITY ASSESSMENT
Authors: Zhebo A. V. , Kotovskaya E. E.
Published: October 2021

The quality of 6 samples of brine cheese was examined, as a result of which deviations in organoleptic and physico-chemical parameters were established.
Attenuation of the Airway and Cardiovascular Responses to Extubation in Chronic Smokers by Prior Treatment with Dexmedetomidine, Fentanyl, and their Combination
Authors: Ahmed Naglaa A. , Yehia Ashraf M. , Mohamed Ahmed H. , Abdulwahhab Asmaa
Published: October 2021

BACKGROUND: Respiratory complications and hemodynamic changes during and after extubation are more common than during tracheal intubation and induction of anesthesia.

AIM: The objective of this study was to compare the efficacy of prior treatment with dexmedetomidine, fentanyl, and their combination on the attenuation of the airway and cardiovascular responses to extubation.

METHODS: The subjects were adult chronic male smokers, representing the population in which secondary response to extubation is most common. A randomized double-blinded comparative trial was conducted on 66 patients who were 20–60 years of age, chronic male smokers, scheduled for elective surgeries, and divided into three equal groups according to given drug 20 min before the end of surgery. Group A (n = 22) received 1 ug. kg−1 dexmedetomidine, Group B (n = 22) received fentanyl 1 ug. kg−1, and Group C (n = 22) received a mixture of the previously used drugs in the same doses. Time to and quality of extubation, airway and hemodynamic responses, and post-operative agitation and sedation were recorded.

RESULTS: Hemodynamic responses and quality of extubation were better in both Groups A and C than patients in Group B at the expense of increasing time to extubation, post-extubation sedation, and delayed recovery in Group C.

CONCLUSION: Single-dose dexmedetomidine 1 ug. kg-1 given 15 min before extubation in chronic cigarette smokers provided better attenuation of the airway and cardiovascular responses to extubation and suctioning with better recovery profile when compared to fentanyl 1 ug. kg-1 and dexmedetomidine mixed with fentanyl in the same previous doses.
β-Catenin Expression and Its Association with Prognostic Factors in Hepatocellular Carcinoma: A Study on Alpha-fetoprotein, Histologic Grade, and Microvascular Invasion
Authors: Rahadiani Nur , Andhini Retnowulan Ignasia , Stephanie Marini , Rini Handjari Diah , Krisnuhoni Ening
Published: October 2021

Background. Hepatocellular carcinoma (HCC), the most common primary liver cancer. In addition to its high incidence, the disease burden is high due to its poor prognosis and high recurrence rate. Some of the currently known clinicopathologic prognostic factors include alpha-fetoprotein (AFP) level, histologic grade, and microvascular invasion. At the molecular level, β-catenin is one of the most common driver mutation found in HCC. The Wnt/β-catenin pathway regulates cellular processes related to initiation, growth, survival, migration, differentiation, and apoptosis. Although the underlying pathogenesis of hepatocarcinogenesis is known, clinical application warrants a greater understanding of the molecular characteristics and tumor phenotype, especially for determining the prognosis. This study aims to analyze the expression of β-catenin and its association with AFP, histologic grade, and microvascular invasion. Materials and methods. Thirty-five samples of surgically resected HCCs at Cipto Mangunkusumo National Referral Hospital were examined. Diagnoses were made based on histopathological and immunohistochemical findings followed by β-catenin staining. β-catenin expression was analyzed to determine difference between variables. Results and conclusions. Here we show that β-catenin expression is significantly associated with low serum alpha-fetoprotein and well to moderate differentiation Implications. Strong nuclear β-catenin expression implies better prognosis in HCC.
Personal and Perceived Stigmas in Adolescents toward Peers with Mental Disorders in West Sumatra Indonesia
Authors: Sarfika Rika , Effendi Nursyirwan , Malini Hema , Edwin Nurdin Adnil
Published: October 2021

BACKGROUND: The number of mental disorders in adolescents tends to increase every year in Indonesia. However, the stigma of mental disorders is a crucial factor that makes teens hide their mental health problem.
AIM: This study aimed to examine personal and perceived among adolescents towards peers with mental disorders (PMD) and to identify predictors of these constructs.
METHODS: This quantitative study with a cross-sectional design recruited 977 adolescents using a cluster random sampling technique. Adolescent stigma was assessed using the Peer Mental Health Stigmatization Scale (PMHSS). Multivariable general linear models (GLMs) was used for analysis.
RESULTS: The study shows that the perceived stigma (M = 36.62, SD = 5,183) tends to be higher than personal stigma (M = 39.49, SD = 5,495).  Higher personal stigma was predicted by a lower level of academic (P < 0.01), lower levels of family monthly income (P < 0.01), and higher perceived stigma (P < 0.001). Higher perceived stigma was predicted by younger age (P < 0.05), lower levels of academic (P < 0.05), higher levels of family monthly income (P < 0.05), and higher personal stigma (P < 0.001).
CONCLUSION: The Findings suggest that stigmatization towards PMD is common among adolescents. The development of intervention programs should be directed at reducing negative perceptions of the environment. The identified predictors must also be considered in the development of future anti-stigma programs.
Macedonian Architecture From 19th Century in The Village of Leshok, Republic of Macedonia
Authors: Petanovski Aleksandar , Spiroski Ivo
Published: October 2021

INTRODUCTION: The old rural architecture in Macedonia is insufficiently studied and in many villages is in the process of extinction, especially in Western Macedonia where there are many villages whose inhabitants have emigrated.
OBJECTIVES: The objective of this research is the folk architecture of the house in the village of Leshok, near Tetovo, and getting acquainted with the other types of objects that are part of the rural-economic yard and are inextricably linked to the daily work, life and customs of the peasant from this region.
MATERIAL AND METHODS: For analysis of the traditional architecture of the houses in the village of Leshok from the late 19th and early 20th centuries, 10 typical houses with different structure and location are chosen, which are identified and displayed by the Google Earth search engine.
RESULTS: The basic characteristics of the architecture of the village house in Leshok are explained, where the economic yard together with the economic objects are included. The functional solutions of the foundations of houses from the end of the 19th and the beginning of the 20th century are shown, the constructions used in the house of Leshok are described, as well as the materials that were used for their construction. In the end we get acquainted with the interior and the design of the premises in the old Macedonian house.
CONCLUSION: Leshok belongs to the group of mountain villages of compact type. The configuration of the terrain, the dead riverbed, dictated the way of construction, where the houses are placed one above the other and each has a clear view of the valley. In that way, the basic architectural features of the Leshok house are formed. It is a typical mountain house built of stone and wood, on two floors and with an open veranda.
Impact of Feng Shui Bedrooms on Self-Assessed Sleep and Well-Being: A Randomized Double-Blind Field Research with Instrumental Biocommunication
Authors: Kryžanowski Špela
Published: October 2021

Chinese feng shui is well-researched in social sciences but under-researched regarding its impact on the well-being of users. The main problem is the isolation of feng shui effects. Participants (n=134) provided a photograph of their bedroom onto which feng shui recommendations were sent long distance (for 4 months), using an instrumental biocommunication device with a computer, white-noise diode and fengshui recommendations database. Three groups were formed, one acted as control (double-blind protocol). Data was collected through self- evaluating questionnaires (n=10) on the quality of sleep and well-being. Data were statistically evaluated with R environment using linear mixed models and the analyses of variables: feng shui support, stress, age and bedroom evaluation. Results for sleep show feng shui as the most statistically significant variable (p=<0.001). For each day the value increases by 0.003 on the Likert scale 1-5. In 120 days, it increases by 0.36. The impact is dynamic and in direct connection with the level of our living environment satisfaction, stress and age. For well-being most statistically significant are stress (p<0.001) and the interaction of feng shui and bedroom rating (p<0.001). Positive feng shui impact is highest for participants without stress and low satisfaction with the bedroom environment.
Understanding the Impact of Development Efforts in Code Quality
Authors: Perez-Castillo Ricardo , Piattini Mario
Published: October 2021

Today, there is no company that does not attempt to control or assure software quality in a greater or lesser extent. Software quality has been mainly studied from the perspectives of the software product and the software process. However, there is no thorough research about how code quality is affected by the software development projects’ contexts. This study analyses how the evolution of the development effort (i.e., the number of developers and their contributions) influences the code quality (i.e., the number of bugs, code smells, cloning, etc). This paper presents a multiple case study that analyses 13 open-source projects from GitHub and SonarCloud, and retrieves more than 95,000 commits and more than 25,000 quality measures. The insights are that more developers or higher number of commits does not necessary influence worse quality levels. After applying a clustering algorithm, it is detected an inverse correlation in some cases where specific efforts were made to improve code quality. The size of commits and the relative weight of developers in their teams might also affect measures like complexity or cloning. Project managers can therefore understand the mentioned relationships and consequently make better decisions based on the information retrieved from code repositories.
Addressing Issues Impacting Advanced Nursing Practice Worldwide
Authors: Kleinpell Ruth , Scanlon Andrew , Hibbert Denise , Ganz Freda , East Linda , Fraser Debbie , Wong Frances , Beauchesne Michelle
Published: October 2021

Advanced practice nursing roles are developing globally, and opportunities for advanced practice nursing are expanding worldwide due to the need for expert nursing care at an advanced level of practice. Yet it is well recognized that barriers exist with respect to APRNs being able to practice to the full extent of their education and training. Addressing barriers to APRN practice worldwide and ensuring that APRNs are able to practice to the full extent of their education and training can help to promote optimal role fulfillment as well as assessment of the impact of the APRN role.
Pratiques d’orientation vers l’infirmière d’éducation thérapeutique : étude qualitative auprès de médecins généralistes et de patients d’une maison de santé en Lorraine
Authors: Hermann-Burteaux Audrey , Crozet Cyril
Published: October 2021

Introduction : pour faire face à l’accroissement du nombre de patients porteurs de maladies chroniques, le dispositif ASALEE favorise la coopération entre les médecins généralistes et des infirmières d’éducation thérapeutique d’une maison de santé lorraine. Ils constatent des comportements d’absence, d’annulation et de report de la première consultation des patients orientés. Objectif : notre recherche explore les pratiques médicales d’orientation des patients à la première consultation d’éducation thérapeutique. Méthode : l’observation de ces pratiques a été couplée à des entretiens semi-directifs. Résultats : quatre médecins et 17 patients ont été observés et questionnés suite à l’orientation à l’infirmière d’éducation thérapeutique pour six d’entre eux et à un médecin spécialiste pour 11 autres. 27 critères et 72 indicateurs concernent la pratique d’orientation à l’ETP. Quinze sont communs aux 22 critères concernant le médecin spécialiste. Ces critères ouvrent des perspectives d’amélioration intéressant l’ETP, comme la Qualité de la relation médecin-patient et le Manque de connaissances et de compétences en ETP. Discussion/conclusion : l’amélioration de la pratique médicale d’orientation à l’éducation thérapeutique est permise par les groupes d’analyse de pratiques professionnelles et par l’acceptabilité sociale de l’ empowerment et de l’engagement des patients.
Statistics of multipliers for hyperbolic rational maps
Authors: Sharp Richard , Stylianou Anastasios
Published: October 2021

In this article, we consider a counting problem for orbits of hyperbolic rational maps on the Riemann sphere, where constraints are placed on the multipliers of orbits. Using arguments from work of Dolgopyat, we consider varying and potentially shrinking intervals, and obtain a result which resembles a local central limit theorem for the logarithm of the absolute value of the multiplier and an equidistribution theorem for the holonomies.
Parameterized splitting theorems and bifurcations for potential operators, Part II: Applications to quasi-linear elliptic equations and systems
Authors: Lu Guangcun
Published: October 2021

This is the second part of a series devoting to the generalizations and applications of common theorems in variational bifurcation theory. Using abstract theorems in the first part we obtain many new bifurcation results for quasi-linear elliptic boundary value problems of higher order.
Fatores Associados à Adesão à Psicoterapia Psicanalítica: um estudo qualitativo
Authors: Lauermann Franciele , Serralta Fernanda Barcellos
Published: October 2021

Devido a sua alta prevalência, o abandono em psicoterapia tem sido um fenômeno amplamente discutido por clínicos e pesquisadores. Considerando as consequências negativas da terminação prematura do tratamento tanto para os pacientes quanto para os terapeutas e serviços de saúde, este estudo busca conhecer fatores que favorecem a adesão à psicoterapia psicanalítica/psicodinâmica. Foram entrevistados seis ex-pacientes de um instituto de formação em psicoterapia psicanalítica que haviam concluído o tratamento em concordância com seus terapeutas, no máximo, há 12 meses. O conteúdo das entrevistas foi transcrito e analisado a partir da metodologia clínico-qualitativa. O corpus gerou quatro categorias e sete subcategorias, que foram discutidas a partir do referencial psicanalítico/psicodinâmico. Os principais facilitadores de adesão encontrados foram: o relacionamento e a aliança terapêutica, os aspectos relacionados ao setting, às características do terapeuta e do próprio paciente, bem como a percepção de mudança no decorrer do processo. Os resultados podem auxiliar os terapeutas em sua prática, contribuindo para minimizar índices tão elevados de evasão, além de ajudar seus pacientes a extrair o máximo benefício possível da intervenção.
Humoral immunity after Pfizer/BioNTech BNT162b2 vaccine in healthcare workers of ASL Roma 2 (Italy)
Authors: Giberna Eliana , Guastafierro Tiziana , Ciaffi Natalia , Nebuloso Elena , Piccoli Stefania , Serao Mattia , Gioffrè Giuseppina , Campitelli Stefania , Colace Maria Grazia , Cava Maria Carmela , De Cristofaro Maria
Published: October 2021

The Unit (COU) of Microbiology and Virology of Sandro Pertini Hospital began monitoring the immune response on a cohort of healthcare operators who received the Pfizer/BioNTech BNT162b2 vaccine. Three different tests for the detection of antibodies against SARS-CoV-2 were used showing 100% of seroconversion after 28 days from the first dose.
Some Impressions of Rehabilitation Services in the U.S.A. and Canada
Authors: Humphrey M. F.
Published: October 2021

No abstract available.
Braille graph paper in charting of strength/duration curves
Authors: Massey Joyce
Published: October 2021

No abstract available.
The Causes, Effects and Control of Bronchial Secretions
Authors: Meintjes F. A.
Published: October 2021

No abstract available.
Evaluation of serum hepcidin and its relationship to iron homeostasis in obese anemic patients
Authors: Alkourashy Shaza A. , El-Salakawy Walaa A. , Saeed Alia M.
Published: October 2021

Context

Obesity is an increasingly recognized medical problem in both high-income and low-income countries owing to poor dietary habits and physical inactivity. This is frequently associated with dysregulated iron homeostasis. Iron deficiency in obese patients might be attributable to imbalanced diet or increased bodily demands. However, a role of enhanced hepcidin expression as a result of proinflammatory milieu in this setting has been contemplated in the recent years.

Objectives

First, we aimed at the measurement of serum hepcidin levels in obese anemic individuals. Second, we aimed at the assessment of the presence or absence of a relationship between its levels and deranged iron homeostatic profile.

Patients and methods

A total of 90 adult participants have been enrolled from the Clinical Hematology and Oncology Unit, Internal Medicine Department, Center ‘X,’ City ‘Z.’ Country ‘Y’. They have been divided into group I: 30 obese anemic patients, group II: 30 obese nonanemic patients, and group III: 30 healthy age-matched and sex-matched controls. Serum hepcidin levels were assayed using hepcidin ELISA kits.

Results

Group I enjoyed much higher serum hepcidin values as compared with either group II or III. Hepcidin level was associated with significantly lower mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, serum iron, and serum ferritin levels. However, it was remarkably associated with higher BMI, red cell distribution width, erythrocyte sedimentation rate, and high-sensitivity C-reactive protein levels.

Conclusion

There is a low state of chronic inflammation in obese anemic individuals associated with higher serum hepcidin levels. This results into repressed iron absorption and release by the liver and phagocytic system, contributing largely to obesity-associated iron deficiency.
Effective biotechnologies for revolutionalizing the livestock industry in Nigeria after COVID-19 pandemic
Authors: Ezekwe A.G. , Machebe N.S. , Uzochukwu I.E.
Published: October 2021

COVID-19 pandemic has caused severe health and hunger challenges both in developed and developing economies of the world thereby posing a serious threat to the economies and food security issues particularly of vulnerable regions of the world. Currently in Nigeria, there is a great increase in the market prices of crops and livestock products occasioned by the prevailing clashes between crop farmer and livestock herders. There is thus a huge gap in the demand and supply of available essential agricultural products leading to the high inflation rate being witnessed in the country today. With the current population of over 200 million which is expected to double by 2050, the task of feeding these Nigerians is daunting and very challenging. To overcome these challenges, the livestock industry in Nigeria needs to be transformed accordingly. FAO report of 2019 had advised African livestock producers to work to expand the scope of their operations and to invest in productivity-enhancing technologies in order to meet the growing demands for livestock products. The adoption of biotechnological innovations already available in animal reproduction, nutrition, health and genetics, is a clear pathway to enhance livestock production in Nigeria. The Nigerian Government is expected to play a leading role by providing enabling environment that will make for easy and seamless adoption of these technologies. Nigerian livestock farmers on their part should be ready and willing to embrace these technologies to enhance the productive capacity of their stock as well as improving their own welfare and economic wellbeing.

Key words: COVID-19 pandemic, biotechnology, livestock industry, development, Nigeria
Policy adjustments for enhanced agricultural production in Nigeria after COVID-19 pandemic
Authors: Enete A.A. , Onyenekwe C.S.
Published: October 2021

The COVID-19 pandemic has caused disruptions to global food supply chains. It has led to severe economic stress and malnutrition particularly in developing countries. This paper outlines the impact of COVID-19 pandemic on agriculture and livelihoods in Nigeria, measures put in place by the Nigerian Government to cushion the effect and parses evidence on programmes and policies that can help speed up sustainable economic recovery that Nigeria desperately needs post COVID-19 pandemic, through agricultural growth. Identifying appropriate policies to enhance agricultural production and trade post COVID-19 pandemic is important for maintaining a robust global food supply. The paper concludes that it may be time for a fundamental reassessment of policies designed to tackle challenges in the agricultural sector in sub-Saharan Africa particularly Nigeria. The state of agriculture in any country is a reflection of the long-term agricultural plan designed and pursued by the Government to move the sector forward. In designing strategies, policies and programmes to enhance agricultural growth, the starting point is to diagnose the challenges faced by the sector and the impacts of previous measures put in place to tackle the challenges, so that lessons could be drawn for designing better and more appropriate policies.

Key words: COVID-19 pandemic, agricultural policy, agrifood systems, agrarian development
Application of biological and digital technologies in resolving the negative effects of COVID-19 pandemic on crop production in Nigeria
Authors: Aba S.C. , Baiyeri K.P.
Published: October 2021

The COVID-19 pandemic has wrecked great havoc in many spheres of life, including education, health, economy, and agriculture. This paper x-rayed the effects of the pandemic on crop production in Nigeria, and efforts made to proffer viable solutions through the application of biological and digital technologies. The impact of COVID-19 pandemic on crop production was palpable in shortage of farm labour and labour immobility, disruption of agricultural input supply chain (e.g., fertilizers, agrochemicals, and seeds) and food distribution network. These irregularities grossly escalated food insecurity challenges, sparked price hikes, increased hunger and food losses. Considering the impact of COVID-19 pandemic on crop production which invariably extends to farmers’ income, food security, family nutrition and health, prompt measures to minimize the onward transmission among key players in crop production and food supply chain are imperative. The application of biological technologies including vaccination, use of natural herbs and spices, organic agriculture options (such as organic manuring, use of botanical protectants, farmers’ own seeds, cover cropping, mulching, biofertilizers, etc.), agricultural mechanization, and the digital technologies (mobile phones, remote sensing services, online platforms, robotics and artificial intelligence) would go a long way in resolving the negative effects of the pandemic on crop production in Nigeria. Strict adherences to the recommended public health safety measures (social distancing, compulsory use of face masks in the public, regular hand hygiene, covering of one’s mouth when sneezing or coughing, disinfection of high touch surfaces) are crucial in curtailing the spread of COVID-19 infection.

Key words: COVID-19 pandemic, crop production, food security, bio-and digital technologies, Nigeria
Incorporation of human factors into a Discrete Event Simulation Model for human centred assembly performance evaluation
Authors: Abubakar M.I. , Wang Q.
Published: October 2021

Discrete Event Simulation (DES) tool is commonly used for the design, analysis, and evaluation of manufacturing systems. Human centred assembly systems offer better system flexibility and responsiveness due to inherent human intelligence and problem-solving abilities; human can deal with product variations and production volumes; and can always adapt themselves to multiple tasks after learning process. Nevertheless, human performance can be unpredictable, and may alter over time due to varying psychological and physiological states, these are often overlooked by researchers when designing, implementing, or evaluating a manufacturing system. In this paper a user-friendly integrated DES method was proposed to enable manufacturing system designers to investigate overall performance of human centred system considering effects of selected human factors. the method can permit manufacturing system designers to evaluate overall manufacturing system performance with considerations of parameters of human factors at early design stage. A case study was carried out using integrated approach; simulation results demonstrate the applicability of this approach.
An evaluation of Quasi-Moment-Method calibrated pathloss models for Benin City Nigeria
Authors: Adelabu M.A.K. , Ayorinde A.A. , Muhammed H.A. , Okewole F.O. , Mowete A.I.
Published: October 2021

This paper introduces the Quasi-Moment-Method (QMM) as a novel radiowave propagation pathloss model calibration tool, and evaluates its performance, using field measurement data from different cellular mobile communication network sites in Benin City, Nigeria. The QMM recognizes the suitability of component parameters of existing basic models for the definition of ‘expansion’ and ‘testing functions’ in a Galerkin approach, and simulations were carried out with the use of a FORTRAN program developed by the authors, supported by matrix inversion in the MATLAB environment. Computational results reveal that in terms of both Root Mean Square (RMS) and Mean Prediction (MP) errors, QMM-calibrated models performed much better than an ‘optimum’ model reported for the NIFOR (Benin City), by a recent publication. As a matter of fact, the QMM-calibrated COST231 (rural area) model recorded reductions in RMS error of between 31.5% and 71% compared with corresponding metrics due to the aforementioned ‘optimum’ model. The simulation results also revealed that of the five basic models (COST231-rural area and suburban city, ECC33 (medium and large sized cities), and Ericsson models) utilized as candidates, the two ECC33 models, whose performances were consistently comparable, represented the best models for QMM-model calibration in the Benin City environments investigated.