bluuebunny/crossref_metadata_2025 huggingface dataset:
Fabrication of Nanocomposite Membrane with Nanomaterial Filler for Desalination
Authors: Alam Muhammad Nur , Raya Indah , Ahmad Ahyar , Taba Paulina , Putri Suriati Eka , Karim Harningsih
Published: April 2024

This review aims to provide a complete overview on the modification of polymer and biopolymer membranes into nanocomposite membrane materials. Fabrication of nanocomposite membranes is carried out by incorporating inorganic filler materials in nanoparticle sizes. Nanomaterials refer to the class of materials that consist of particulate substances with any dimension of less than 100 nm at least. The properties of nanomaterials include large specific surface area, crystalline structure, shape (that regulates most of its properties as well as their unique attributes), surface morphology, and assembling phenomena. This review primarily concentrates on the recent nanotechnology-based practices to enrich the outcomes of desalination on the footings of nanocomposites, developed practicing distinct nanomaterials. A classification for various forms of nanomaterials used for building nanocomposites has also been illustrated. Special emphasis has been given to the usage of nanocomposites constructed from several nanomaterials such as nanoparticles, nanotubes, nanoshells, nanofibers, nanocapsules, nanosheets and quantum dots, and how these nanocomposites have been utilized for desalination.
Spectrophotometric Determination of Sodium Sulfacetamide Using Pyrocatechol as an Oxidative Coupling Agent
Authors: Ali Marib Ismail , Humeidy Israa Talib
Published: April 2024

Oxidative coupling reaction is one of the simplest and fastest spectrophotometric methods for measuring sodium sulfacetamide (SCS) in pure formulations and pharmaceutical formulations (eye ointment) when compared to other methods that require difficult and costly operating conditions. Here, a new approach for quantifying SCS drug spectrophotometrically by oxidative coupling was described. The research is based on the oxidation of the drug with potassium periodate and then conjugation with pyrocatechol reagent in the neutral medium, which results in a water-soluble and stable reddish-brown product that had an absorption band at 500.5 nm. In this work, oxidant agent quantity, coupling reagent quantity, oxidation time, temperature effect, stoichiometry between SCS and pyrocatechol, interference effect, and calibration curve were all studied. Beer's law linearity ranged from 6.25–112.5 µg mL−1. The molar absorptivity, Sandell’s index, detection limit, determination coefficient, and average recovery percentage were 5185.7 L mol−1 cm−1, 0.049 μg cm−2, 0.0889 µg mL−1, 0.9988, and 100.34% respectively. The determination of sulfacetamide in pharmaceutical preparation eye, ointment was successful using this method.
A Deep Overview of Anticoagulant Drugs: Recent Synthesis and Their Activity Assay
Authors: Astuti Engrid Juni , Ibrahim Slamet , Zulfikar Muhammad Ali , Damayanti Sophi
Published: April 2024

During the unprecedented COVID-19 pandemic, anticoagulant drugs have emerged as a crucial component of treatment alongside antivirus medications. Patients with severe COVID-19 frequently have critical conditions marked by blood clot development, necessitating the administration of anticoagulants. This review aims to provide a comprehensive overview of various anticoagulant drugs, their synthesis methods, and assays employed to predict their anticoagulant activity. Notable anticoagulant categories frequently utilized include oral anticoagulants heparin, non-vitamin K antagonists, and vitamin K antagonists. In recent years, the development of new anticoagulants has seen a shift towards a multifaceted approach that combines in silico prediction with in vitro and in vivo assays. In silico prediction techniques play a pivotal role in the initial screening process. This integrated approach has yielded promising results, paving the way for the synthesis of novel anticoagulant candidates, as substantiated by a battery of in vitro, in vivo, and ex-vivo tests.
Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one
Authors: Sami Safa , Shaalan Naser
Published: April 2024

In the present study, a novel ligand (L) made of 2-hydroxynaphthaldehyde and 3-hydrazone-1,3-dihydro-indole-2-one(3-[(3-hydroxynaphthalen-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one). The ligand was characterized by FTIR, UV-vis, mass, 1H-NMR, 13C-NMR, and CHN elemental analysis. New complexes of this ligand were created by treating methanol and a drop of DMF solution of the produced ligand with the hydrated metal salts of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) in a molar ratio of 2:1 (L:M). As a result, complexes have been emerged and identified FTIR, UV-vis, C.H.N., chloride-containing, molar conductance, magnetic susceptibility, and atomic absorption. The characterization result for each complex indicated complexes with octahedral coordination geometry and tridentates with metal to ligand ratios of 1:2. The biological activities of the new compounds were examined against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) giving an acceptable inhibition efficiency.
Synthesis, Characterization, and Electrochemical Study of Novel Porphyrin Derivatives as Corrosion Inhibitors for Carbon Steel in HCl Solutions
Authors: Jaafar Mohammed Thamer , Ahmed Luma Majeed , Haiwal Rahman Tama
Published: April 2024

This study involves the synthesis of some porphyrins derivatives, these are termed as 4,4',4'',4'''-(porphyrin-5,10,15,20-tetrayl)tetrakis(N-(6-aminoacridin-3-yl)benzamide) (3a), 4,4',4'',4'''-(porphyrin-5,10,15,20-tetrayl)tetrakis(N-(5-methoxybenzo[d]thiazol-2-yl)benzamide) (3b), 4,4'-(10,20-bis(3-hydroxyphenyl)porphyrin-5,15-diyl)bis(N-(6-aminoacridin-3yl)benzamide) (5a), and 4,4'-(10,20-bis(3-hydroxyphenyl)porphyrin-5,15-diyl)bis(N-(benzo[d]thiazol-2-yl)benzamide) (5b). These derivatives were synthesized using open circuit potential (OCP) and potentiodynamic polarization (PDP) in 0.1 M HCl solution methods. These derivatives were characterized using nuclear magnetic resonance (1H- and 13C-NMR) spectroscopy, mass spectra (ESI), and micro elemental analysis (CHN). The activity of these synthesized materials was investigated as a corrosion inhibitor using carbon steel (CS) as a model for corroded materials. The obtained results showed that the synthesized porphyrins derivatives were effective corrosion inhibitors to 0.1 M HCl solution for CS. In the case of the derivative 3a, a maximum inhibition efficiency (IE%) was recorded and it was around 74%. The derivative 3b showed an IE% of around 68.11%, while the %IE of 5a and 5b were around 18.98% and 45.16%, respectively. The best IE% value that was recorded for the derivative 3a has the potential to be effective anticorrosive coatings for industrial applications and act as mixture inhibitor because their ΔEcorr values are less than 85 mV. On the CS surface following treatment with compound 3a, the inhibitor mechanism for acidic medium (HCl) was investigated.
Formulation and Characterization of a Pluronic F127 Polymeric Micelle as a Nanocarrier for Berberine Delivery
Authors: Alyasari Noora Kadhim Hadi , Almzaiel Anwar Jasib
Published: April 2024

Berberine's (Ber’s) lower water solubility, which leads to low bioavailability, poses substantial delivery-related barriers to its therapeutic efficacy. Thus, a new approach to improving Ber's delivery and bioavailability is required. In this study, a Pluronic F127 micelle containing Ber (mBer) was formulated using thin-film hydration technique with the intention of resolving challenging issues associated with Ber delivery. The micelle was tested for drug loading and retention efficiency, size, zeta potential, shape, in vitro release, and in vitro toxicity. The spherical micelles that were made had an average encapsulation efficiency of 85%, a hydrodynamic size of 82.2 nm, a polydispersity of 0.176, and a zeta potential of −47.4 mV. The results of Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) indicated that Ber was physically entrapped and in an amorphous state within the synthesized micelles. Compared to the free Ber solution, the in vitro release of Ber from micelles exhibited both short-term rapid release and sustained release. The mBer was shown to be relatively non-toxic to blood cells via an in vitro hemolysis assay. Our findings showed that polymeric F127 micelles could be a simple nanocarrier for Ber delivery, which can be used to enhance the therapeutic efficiency of Ber.
Methotrexate-Polymer Nanocomposites for Targeted Pulmonary Drug Delivery
Authors: AL-Sarayrah Aseel Khaled Mohammad , Hussein-Al-Ali Samer Hasan , Haddad Mike Khalil , Kalil Dalia
Published: April 2024

Nanocomposite formulation is a suitable technology that enables the development of successful dry powder inhalers. The methotrexate (MTX) and polyamide-disulfide (polymer) were used as a model to form MTX-polymer nanocomposites. Different amounts of the independent variable, MTX (0.025 and 0.050 g), polymer (0.05 and 0.01 g), pH (6.7 and 11.3), and across-linker ferric chloride (FeCl3) (0.05 and 0.10 g) were used. The loading efficiency and particle size were dependent variables. The optimized formula can be obtained with the highest loading efficiency and optimum particle size. This formula can be collected by using 0.025 g of drug, 0.079 g of polymer, 0.050 g of FeCl3, and pH = 6.7. The release of MTX from the nanocomposites occurs in two release steps; the first release step starts from the beginning up to 60 min, followed by a continuous release phase within 60 min. The results of the NGI analysis demonstrated that 28.1% of the nominated dose in each puff reached the lower parts of the respiratory system, an indication that the nanocomposites can be used in the delivery of MTX as a respiratory system.
The Impact of Substitution of Diphenyl Dialumene on the Molecular Structure and Energetic Properties
Authors: Babikir Salma , Abdalla Sahar , Mohamed Wefag , Umar Yunusa
Published: April 2024

The molecular structure, energetic properties, electronic, and vibrational spectroscopy of meta-substituted phenyl dialumene, DPD (Ar–Al=Al–Ar; Ar of the formula C6H5X2, where X = H, CH3, NH2, OH, F, Cl, Br, NO2, and COOH) are investigated by DFT. The singlet states of unsubstituted and substituted DPD adopt trans-planar geometry, while the triplet states adopt non-planar trans-bent geometry. The Al=Al bond length of unsubstituted DPD-H in a singlet state is calculated to be 2.734 Å, and there is no systematic and significant change upon substitution (2.734–2.744 Å). The substitution affects the absolute energy, ionization potential, electron affinity, and reorganization energy. The wavelength of maximum absorbance of DPD-H is determined to be 443 nm, and the substitute analogues DPD-X (X = OH, F, Cl, Br, NO2, CHO, COOH) show a hypsochromic shift, while DPD-CH3 and DPD-NH2 exhibit a bathochromic effect. The HOMO to LUMO+1 transition is the major transition for the meta-substituted DPD, except for X=NO2, where the transition is to LUMO+2. Considering the reorganization energy values, meta-substituted DPD can be useful as hole transporters. In addition, the theoretical data will aid in predicting the behavior of this class of compounds, facilitating the design and synthesis of similar compounds with desired properties.
Photodegradation of Phenol under Visible Light Irradiation Using Cu-N-codoped ZrTiO4 Composite as a High-Performance Photocatalyst
Authors: Fauzi Wanda Putra , Kurniawan Rian , Sudiono Sri , Prasetyo Niko , Syoufian Akhmad
Published: April 2024

Codoping of nitrogen and copper into zirconium titanate composite (Cu-N-codoped ZrTiO4) was carried out through a sol-gel process. This study aimed to investigate the effect of copper and nitrogen dopants on the photocatalytic activity of ZrTiO4 composite in degrading phenol. To prepare the composite, an aqueous suspension of zirconia (ZrO2) alongside a fixed amount of urea and various amount of copper sulfate was added dropwise into diluted titanium(IV) tetraisopropoxide (TTIP) in ethanol. The composites were calcined at temperatures of 500, 700, and 900 °C. Fourier-transform infrared spectrophotometry (FTIR), X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray (SEM-EDX) mapping, and specular reflectance UV-visible spectrophotometry (SR UV-vis) were used for their characterization of composite. The photocatalytic activity was evaluated by adding the composite into a 10 mg L−1 phenol solution for various irradiation time spans. The remaining concentration of phenol solution was determined by absorption at 269 nm. Cu-N-codoped ZrTiO4 composite containing 5% Cu calcined at 500 °C demonstrated the highest observed rate constant and a significant band gap decrease from 3.13 to 2.68 eV.
Servant Leadership: Implementing the Principal's Role in Creating a Humanistic Education
Authors: Effendi Yulius Rustan , Erb Maribeth
Published: April 2024

Introduction/Main Objectives: This study aims to describe the leadership role of school principals based on spiritual-moral values in conditioning humanistic education. Background Problems: While servant leadership has been investigated from various angles, its application to principal leadership, primarily through a moral-spiritual lens, remains understudied. Novelty: This study underscores a gap in the literature on school principals' leadership, advocating for a spiritual-moral values approach to foster a humanistic school environment. Principals prioritize teachers' and students' interests, embodying servant leadership through active listening, open communication, and feedback acceptance. They also integrate moral, religious, and spiritual values into their leadership philosophy.  Principal A hold holds regular open meetings, establishes communication channels, organizes activities promoting values, and implements anti-harassment policies. Principal B develops special programs and collaborates with teachers to infuse moral and spiritual aspects into subjects. Principal C integrates character education, offers teacher training on ethics, and encourages role modeling of ethical values. Research Methods: This research uses qualitative methods and a case study design, utilizing in-depth interviews, participant observation, and document analysis. The analysis includes a modified analytic approach with validation data through credibility, transferability, reliability, and confirmability assessments. Finding/Results: The study reveals that servant leadership fosters altruism, faithfulness, and morality, cultivating a humanistic learning environment and promoting personal awareness, psychological well-being, and ethical wisdom. Conclusion: In education, servant leadership promotes dialogue and humanistic values, emphasizing shared values over authority among school community members.
Effectiveness and Feasibility of virtual international exchange program for occupational therapy students to develop the international perspective and professional skills -Mix-method study
Authors: Suyama Natsuka , Inoue Kaoru , Hidayat Muhammad Sahid , Sasaki Chihiro , Shioji Rieko
Published: April 2024

Background: Virtual international exchange programs have been promoted; however, the effectiveness of the programs has not yet been examined well in the field of occupational therapy (OT) field. This study aimed to examine the effectiveness and feasibility of a virtual international exchange program for OT students.Methods: Mix-method was applied in this study.Two universities from Japan and Indonesia created an exchange program to cultivate international perspectives and facilitate gaining OT professional knowledge and skills, as well as learning basic scientific study skills. Questionnaires on international minded and program evaluations, which were analyzed by descriptive analysis, were given to the participants before and after the program. Focus group interviews, which were analyzed with reflective thematic analysis, were conducted after the program.Results: Ten students joined the program, six students answered the questionnaires, and eight students participated in the focus group interviews. Students were satisfied with the program overall, even though there were no significant changes in the total scores of the international minded between before and after the program. In the focus group interviews, the participants mentioned their motivations for participating in the program, program evaluation, international minded, and self-growing awareness. The participants expressed that they gained OT professional knowledge and academic skills from the program.Conclusion: As a feasible virtual program, well-organized programs considering the students’ academic learning skills and interests could provide opportunities for individual development, acquiring professional knowledge, and incite self-growing. In addition, the result might show the effectiveness of virtual programs to cultivate international perspective and professional knowledge.
The Ideorealm of Translation from the Perspective of Translation Horizon Theory: A Case Study of a Happy Excursion
Authors: Zhao Mengyao , Du Yusheng
Published: April 2024

Professor Chen Daliang proposed the Chinese Translation Theory with “Translation Horizon” as its core, explaining the three states of literary translations: sense, flavor and ideorealm, constructing a theoretical system for the theory of translation horizon, which has Chinese characteristics and represents an innovative development of traditional Chinese translation theories. As the first chapter of Zhuangzi, A Happy Excursion can be regarded as representative of Zhuangzi both in terms of thought and artistry; it contains rich wisdom of classical Chinese philosophy. This paper takes Translation Horizon Theory as the theoretical framework through studying Lin Yutang’s English version of A Happy Excursion so as to explore strategies conducive to promoting Chinese culture by means of literature translation, and to building Chinese characteristic translation studies system, aiming at providing reference for translation of traditional Chinese works.
The Place of Women in Domestic and Agricultural Decision-Making: An Analysis of Gochhi Village in Jhajjar District
Authors: Arun Arun
Published: April 2024

Women make up around half of India's population and are crucial to expanding the agricultural industry. We may state that women are the foundation of agriculture and related fields. As wage workers, farmers, co-farmers, farm managers, and family carers, women are vital to the agricultural industry. In addition to working in related fields like horticulture, cattle, and fishing, women also cultivate crops. According to the 2011 report by the Food and Agriculture Organisation (FAO), there is a greater proportion of women working in the agriculture industry in Asian countries as compared to other regions. Women began collecting seeds from the local plants and growing those that caught their attention regarding food, feed, fodder, fiber, and fuel. According to estimates from the Food and Agriculture Organisation (FAO), women generate between 60 and 80 percent of the food in underdeveloped nations. The study's main goal is to examine how women participate in family and agricultural decision-making. Research indicates that women are significant contributors to the decision-making process. 39.47 percent of female agricultural laborers receive assistance from their male partners in using fertilizers, 23.70 percent in purchasing agricultural equipment, and 57.90 percent in altering crop patterns.
The Social Contract of “Tapat Ko Linis Ko” Among Senior High School Students in the Philippines
Authors: Gabay Paul John V. , Cruz Prince Leander F. Dela , S. Pante Julianne
Published: April 2024

On December 23, 1975, former president Ferdinand E. Marcos Sr. signed the Presidential Decree No. 856, also known as the “Sanitation Code of the Philippines”, through the Department of Health, aimed to enhance the lives of Filipinos by focusing on public health services essential for the protection and promotion of the health of people. One of its provisions is the launching of the Tapat ko, Linis ko in the streets, translated as “my line, my responsibility" as cited in Chapter 18, Section 83d that states “streets shall be kept clean by occupants or owners of properties lining the streets from the line of the property to the middle of the street and from one property to the other”. This became a social contract among the citizens of the Philippines. Forty-nine years later, this study assessed the awareness towards the social contract of students in engaging in the Tapat ko, Linis ko program. 100 randomly selected senior high school students were the respondents of this study. The researchers used printed survey questionnaires for data gathering. The results revealed that these students were still aware of the Tapat ko, Linis ko and had been actively participating in the said social contract. The results also showed the social contract of the senior high school students in the Tapat ko, Linis ko through practice, engagement, and encouragement. The researchers recommended intensification programs to strengthen the engagement of senior high school students towards Tapat ko, Linis ko in achieving engaged citizenship.
ДИФРАКЦИОННАЯ РЕШЕТКА КАК СРЕДСТВО МЕТРОЛОГИЧЕСКОГО СОПРОВОЖДЕНИЯ МИКРОСКОПИИ
Authors: Ахметова А.И. , Терентьев А.Д. , Сенотрусова С.А. , Советников Т.О. , Яминский Д.И. , Попов В.В. , Яминский И.В.
Published: April 2024

Визуализация биомедицинских образцов в их естественной среде в микро- и наномасштабе имеет решающее значение для изучения фундаментальных принципов функционирования биосистем со сложным взаимодействием. Для изучения динамических биологических процессов требуется микроскопическая система с множеством измерительных возможностей, высоким пространственным и вре-
менным разрешением, универсальными средами визуализации и возможностями локального манипулирования. Перспективными инструментами для этих задач являются сканирующая капиллярная микроскопия и микролинзовая микроскопия, однако корректная работа ни одной из этих методик невозможна без метрологического сопровождения. В данной работе демонстрируется возможность использования для этих целей образца дифракционной решетки.
Dark Tracer Early Malware Detection Based on Spatiotemporal Patterns Using Xgboost Algorithms
Authors: Rajeswari Ms. A Mounika
Published: April 2024

Abstract: Cyber assaults are on the rise throughout the world, therefore it's important to spot patterns so we can respond appropriately. Due to the lack of genuine communication on the darknet, an underused area for IP addresses, it is very easy to observe and analyse random cyber assaults. Similar spatiotemporal patterns are commonly seen in malware's indiscriminate scanning efforts, which are used to propagate infestations. These tendencies are also detected on the darknet. Our main emphasis is on abnormal spatiotemporal examples seen in darknet traffic information to handle the issue of early malware movement discovery. In our earlier research, we suggested algorithms that use three separate machine learning techniques to automatically predict and identify real-time aberrant spatiotemporal patterns of darknet traffic. In this exploration, we coordinated all of the beforehand suggested approaches into a unified framework called Dark-TRACER and tested its detection capabilities for various malware behaviours using quantitative tests. We used data collected from our large-scale darknet sensors, which cover the period from October 2018 to October 2020, to analyse darknet activity at subnet sizes of up to /17. The findingsshow that the approaches' shortcomings operate together, and the suggested framework has a 100% recall rate overall.On top of that, unlike trustworthy third-party security research organisations, Dark-TRACER finds malware activities an average of 153.6 days before they are publicised. Lastly, we calculated how much it would cost to employ human analysts to putthe suggested system into action, and we proved that it would take around seven and a half hours for two analysts to carry outall the routine tasks required to run the framework.
Safeguarding Cyber Ecosystems: Machine Learning and Data Mining Approaches for Proactive Phishing Detection in Websites
Authors: Bagewadi Santosh S.
Published: April 2024

Abstract: The prevalence of cyber threats, notably phishing attacks, presents a significant challenge in the digital realm with the increasing reliance on the internet. Phishing, where victims' credentials are illicitly acquired through deceptive websites resembling legitimate ones, is a particularly concerning form of cybercrime. This paper proposes an innovative system utilizing Machine Learning and Data Mining techniques to detect both established and newly generated phishing URLs without historical behavioral data. The system, embodied in a Chrome browser plugin, operates in real-time to provide immediate protection as users browse web pages. A distinctive feature of this system is its capability to identify phishing websites lacking prior behavioral patterns, ensuring adaptability to evolving cyber threats. Through comprehensive training with an extensive dataset, the model powering the plugin aims for high accuracy in detecting phishing attempts. By deploying advanced Machine Learning methodologies, the system discerns subtle patterns and characteristics intrinsic to phishing URLs, effectively distinguishing them from legitimate websites. The ultimate objective is to enhance cyber security by providing users with a robust and proactive tool against the growing sophistication of phishing attacks, thereby contributing to the ongoing efforts to create a secure online environment amidst the dynamic landscape of cyber threats.
Istopathology Image Colorization for Diagnosis
Authors: Veni CH. Krishna
Published: April 2024

Abstract: This paper reviews Histopathology image colorization for diagnosis. Histopathology refers to the examination of invasive or less invasive biopsy sample by a pathologist under microscope for locating, analysing and classifying most of the diseases like cancer. The analysis of histopathological image is done manually by the pathologist to detect disease which leads to subjective diagnosis of sample and varies with level of expertise of examiner. The histopathologist meticulously evaluates tissue architecture, cellular arrangement, and anomalies in cell morphology to discern between benign and malignant conditions within the image. However, this process is labor-intensive and susceptible to both intra and inter-observer variability. To mitigate these challenges, there arises a necessity for computer-assisted image analysis, facilitating a quantitative approach to tissue diagnosis. The process which is useful to analyse the tissue. Pathologist who can observed the tissue under the microscope which has low resolution by colorization of the tissue which gives the clarity in the tissue. The actual process which can be done by the manually which would be taken the long time and accuracy rate would the low. When use this model it would give the highly accuracy rate and also take the less time to analyse the tissue. In this model we have trained the thousands of tissues which contain the non-cancer tissues and the cancer tissues, When trained with the large dataset then it would give the accuracy rate also high
Perceived Factors of Job Search Anxiety among Postgraduate Final Year Students – A Qualitative Study
Authors: R Ms. Snekha
Published: April 2024

Abstract: This qualitative study aims to explore the factors contributing to job search anxiety among final-year postgraduate students. The research objective is to understand the perspectives and factors related to job search anxiety in this specific group. A purposive sampling technique will be used to select 10 participants who are final-year postgraduate students actively seeking or planning to seek employment and experiencing job search anxiety. Data will be collected through face-to-face, one-on-one semi-structured interviews, which will be audio-recorded and transcribed for analysis. Thematic analysis will be employed to identify patterns and themes within the data. The findings of this study will provide insights into the factors influencing job search anxiety among final-year postgraduate students, contributing to the existing literature on this topic.
Hubungan kepercayaan diri dengan kecemasan sosial pada remaja
Authors: Wardhana Nadya Rizky Salsabila , Hudaniah  , Sakinah Nur Rokhmah
Published: April 2024

Navigating complex social situations can be challenging for adolescents who lead an active social life, potentially leading to social anxiety. Social anxiety can be overcome by having self-confidence. The purpose of this study is to determine the relationship between self-confidence and social anxiety in adolescents. The sample in this study with 213 teenagers from several regions in Indonesia, using the Simple Random Sampling. The design of the research used is a correlational design with Pearson correlation analysis techniques with SPSS version 25. The results of the study found that r= -0,206, p= 0,002 the meaning of significant negative relationship between self-confidence and social anxiety in adolescents, meaning that the higher the self-confidence it has, the lower the social anxiety experienced, and vice versa.
Dukungan keluarga dan job crafting pada karyawan wanita yang telah menikah
Authors: Kholifah Umi Sholihah  , Hidayatillah Dwi Hasnalathifani , Nabila Aula Fata
Published: April 2024

Married women employees will experience difficulties in balancing multiple roles which will have an impact on employee welfare so that employees will have difficulty carrying out job crafting. The aim of this research is to determine the effect of family support on job crafting among married women employees. This research is quantitative research. Sampling used convenience sampling involving 51 married working women. Data analysis used simple linear regression with SPSS 25. This research found that family support had a positive correlation with job crafting as indicated by a significant value of 0,012. The effective contribution given by family support to job crafting is 12,3\%. Based on this research, to improve job crafting, the government or academics can provide education on the importance of family support for a working woman.
The Regulatory Affairs Automation tools used in the Pharmaceutical Industry: An overview
Authors: Chandrasekaran Kumar , Pramod Kumar T M , Balamuralidhara V
Published: April 2024

Automation is becoming increasingly prevalent in various industries, including healthcare and pharmaceuticals. The pharmaceutical business is influenced by a variety of worldwide trends, with one of the most significant being the use of automation technologies, which will have a transformative effect on the research and development of new pharmaceutical products as well as the speed and efficiency with which products reach patients in need. Regulatory automation is enabled by a variety of technology tools, such as Electronic Document Management Systems, Regulatory Information Management (RIM) Systems, Artificial Intelligence (AI) Analytics Tools, Natural Language Processing (NLP) Tools, and Submission Publishing Tools. Automation tools can be used to automate regulatory activities such as administrative work, dossier completion, data extraction, auditing, regulatory implementation as well as quality management. Automation tools establish process links and minimize complexity, resulting in a more efficient management system. Human-AI interaction creates new prospects in regulatory concerns. This article investigates the potential use of automation techniques in pharmaceutical regulatory concerns.
Quality of examination gloves in health facilities in Addis Ababa, Ethiopia
Authors: Mehari Yisihak Abraham , Berhane Yemane , Borta Heran Gerba , Gebre Michael Kidanemariam
Published: April 2024

Background: Examination gloves are used in health facilities to protect health professionals and patients from the risk of infection and reduce opportunities for cross-transmission of infectious microorganisms. Poor-quality examination gloves can expose health professionals to infectious diseases such as Covid-19, Hepatitis, HIV/AIDS, and other contagious diseases. Hence, this study aimed to assess the quality of examination gloves in health facilities in Addis Ababa.

Methods: A cross-sectional study design was employed. The examination gloves were collected from randomly selected health facilities in Addis Ababa. The gloves were examined following standard procedure in the Ethiopian Food and Drug Authority. Holes in the examination gloves were detected using the watertight (leakage test) and geometrical dimensions such as thickness, width, and length were measured.

Results: A total of 2500 selected examination gloves were collected between Feb 10 and Feb 20, 2021. The gloves were sampled from health facilities in Addis Ababa. From the total samples collected, only 2280 examination gloves of five different brands were tested, which makes the response rate 91.2%. The proportion of gloves with holes detected ranged from 5.7% to 21.9%. Overall, only 0.17% and 3.2% of the gloves had width and length below standard, respectively. None of the gloves tested in this study had a thickness below the standard.

Conclusions: All brands of examination gloves tested had a higher hole (leakage) rate than the acceptable quality limit. This implies there is a substantial risk of infectious disease transmission to health professionals and patients in healthcare settings. Hence, regulatory enforcements need to be strengthened across the life cycle of the product.
Overview of Post-approval Submissions Management in US, Europe and Canada
Authors: Patel Charmi , Patel Richa , Kanaki Niranjan , Movaliya Vinit , Deshpande Shrikalp , Zaveri Maitreyi
Published: April 2024

In today’s business era & competition in pharmaceutical industries, post-approval evaluation & cGMP compliance plays an important role. Regulatory approval is a critical milestone in the lifecycle of pharmaceuticals and medical devices, ensuring their safety, efficacy, and quality before entering the market. A regulatory affair is a bridge between pharma industry and health authorities.

Post-Approval function in Regulatory Affairs department plays a major role in supporting continuous commercialization and facilitating for its implementation. This function are responsible to provide strategic regulatory inputs to plant team on their proposals and to facilitate smooth submission followed by acceptance/ approval. In the USA, the Food and Drug Administration (FDA) governs the regulatory process, employing a thorough and well-defined approach to submission evaluation. Europe, with the European Medicines Agency (EMA) at its helm, utilizes a centralized procedure for marketing authorization, harmonizing regulations across member states. Meanwhile, Health Canada oversees regulatory activities in Canada, emphasizing a risk-based approach to ensure public safety.

Post-approval submission management is equally vital in maintaining compliance and ensuring ongoing product safety. This paper delves into the strategies and best practices for handling post-approval changes, variations, and renewals. It examines the role of regulatory intelligence, life cycle management, and effective communication with regulatory agencies to navigate the evolving regulatory landscape.

By comparing and contrasting the regulatory processes in the USA, Europe and Canada, this overview aims to provide valuable insights for pharmaceutical and medical device companies seeking global market access. Understanding the intricacies of regulatory submission and post-approval submission management across these regions is essential for successful product development, commercialisation and long-term regulatory compliance.
De compromisos y aversiones. Intervenciones universitarias en la administración de la pena en cárceles de Córdoba (Argentina)
Authors: Blazquez Nahuel
Published: April 2024

En el presente texto exploro de qué manera las relaciones que involucran a actores universitarios con agentes penitenciarios y personas privadas de libertad están atravesadas por connotaciones morales. Encarar esta cuestión conlleva necesariamente el ejercicio de indagar sobre el lugar que ocupan las fronteras morales obturando/posibilitando cursos particulares de acción. ¿Qué hacemos cuando hacemos extensión universitaria en cárceles? ¿Quién “merece” recibir educación superior en estos contextos y cómo opera la “vulnerabilidad” cuando pensamos la administración de la pena sobre ciertos sujetos? ¿Qué significa tener “compromiso” en estos territorios y qué sentir “aversión” ante determinadas personas detenidas? ¿Y si la “aversión” se dirige hacia trabajadoras del Servicio Penitenciario qué sustancia nutre el “compromiso” de derechos humanos que asume la universidad? Me interesa indagar sobre las asimetrías generadas en torno al “compromiso” y la “aversión” con sus respectivos procesos de sujeción/subjetivación que convierten a algunas personas privadas de la libertad en presos “apreciados” y a otros en “despreciados”. Las reflexiones giran en torno a algunos acontecimientos observados durante el trabajo de campo: escenas etnográficas, análisis de documentos y programas de gobierno en el que se busca examinar cómo los derechos humanos son impregnados moralmente.
Apresentação: “Entre a tradição e a inovação”: tensões e negociações entre as categorias religião, secular e patrimônio em contextos lusófonos
Authors: Bartel Bruno Ferraz , Saraiva Clara
Published: April 2024

A estrutura do dossiê foi modelada com base em estudos nos quais práticas religiosas e seculares são abordadas de maneira interligada, evitando sua análise isolada ou encará-los como termos descritivos neutros. Em vez disso, foram tratadas como elementos intrínsecos ao próprio objeto de investigação ou como ferramentas analíticas que se conectam a outras categorias relevantes, como patrimônio, modernidade e nação. Nosso objetivo era compilar etnografias que destacassem as novas dinâmicas em que “sacralidade e secularidade se informam, reforçam e transbordam uma para a outra”, especialmente nos processos de “patrimonialização do sagrado” e “sacralização do patrimônio”. Partimos do conceito de “sagrado secular”, que abrange os processos entrelaçados de secularização e sacralização. Nesse contexto, ideias, sentimentos, emoções, motivações, experiências, percepções sobre pessoas, objetos, imagens, representações ou lugares se entrelaçam, se fundem e, por vezes, entram em conflito. Essa abordagem foi inspirada no insight de Talal Asad e Saba Mahmood de que o regime secular não se opõe necessariamente à religião. A base dessa perspectiva reside na compreensão da religião como um processo de construção social complexo, que entrelaça história e poder. Isso permite identificar múltiplos agentes sociais competindo na construção de suas fontes de autoridade, reivindicando a “herança” por meio de discursos e práticas. Portanto nosso enfoque não se volta para a separação entre categorias tais como religião e secular, mas sim para o modo como elas participam dos processos de sacralização e dessacralização dos empreendimentos patrimoniais.
CONCENTRAÇÃO DE FORÇAS PRODUTIVAS, LUTA DE CLASSES E IMPOSSIBILIDADE DE UM “SISTEMA NACIONAL DE EDUCAÇÃO” UNITÁRIO
Authors: Peixoto Elza Margarida de Mendonça
Published: April 2024

O artigo aponta como eixo central da análise a íntima conexão entre formação de professores e formação da classe trabalhadora, o que exige reconhecer como os que controlam as forças produtivas trabalharam, na formação social brasileira, para estruturar objetivamente a formação da classe trabalhadora por ramos de produção. Neste âmbito, abre-se a polêmica sobre a impossibilidade de um “Sistema Nacional de Educação” em relações de produção marcadas pela acirrada concentração de forças produtivas e da luta de classes.
Palavras-chave: Capitalismo; formação social brasileira; formação; classe trabalhadora; professores.
COMPETÊNCIAS SOCIOEMOCIONAIS: UMA “NOVA” PEDAGOGIA? ESTUDO DOS FUNDAMENTOS DE UMA PERSPECTIVA EDUCACIONAL EMERGENTE
Authors: Magalhães Jonas Emanuel Pinto
Published: April 2024

Essa tese tem como tema a noção de competências socioemocionais e como objeto de estudo a sua incorporação nas políticas curriculares da educação nacional. De modo mais específico, busca identificar e analisar os fundamentos econômicos, políticos, ideológicos e epistemológicos que orientam as propostas de formação de competências socioemocionais na atualidade. Além disso, e tendo como referencial teórico-metodológico o materialismo histórico e dialético, analisamos, no contexto da crise do capital e do neoliberalismo, a construção e implementação dessa nova agenda educacional por organizações como a Organização para a Cooperação e Desenvolvimento Econômico (OCDE) e o Instituto Ayrton Senna (IAS). A progressiva projeção alcançada pela noção de competências socioemocionais no Brasil, combinadas com a apropriação apressada e, via de regra, pouco crítica desse novo slogan pedagógico justifica a investigação de suas bases epistemológicas, políticas e sócio-históricas, bem como suas implicações ideológicas e pedagógicas.
EDUCAÇÃO PROFISSIONAL E PRÁXIS DA ECONOMIA SOLIDÁRIA: UMA ANÁLISE A PARTIR DAS CONTRIBUIÇÕES DE E. P. THOMPSON
Authors: De Almeida Vieira Mauro Rogério
Published: April 2024

O artigo indica como a experiência da classe trabalhadora na economia solidária contribui para a práxis político-educativa da educação profissional. Seguindo Thompson, parte-se da compreensão de que o ‘fazer-se’ da educação profissional é marcado pela disputa da formação da classe trabalhadora. Desse modo, a partir da investigação teórica e de observação-participante do projeto ‘GerAção Solidária/IFRN’, constata-se que a articulação da experiência de classe na economia solidária com a educação profissional promove um restabelecimento dos laços entre educação e os anseios da classes populares.
Palavras-chave: Educação profissional; Práxis; Experiência; Economia Solidária; E. P. Thompson
O EMPREENDEDORISMO COMO PROJETO DE VIDA JUVENIL NO ENSINO MÉDIO DA REDE ESTADUAL DO RIO DE JANEIRO
Authors: Barbosa Carlos Soares , Paranhos Michelle
Published: April 2024

Este artigo aborda a reformulação curricular do ensino médio na rede estadual de educação do Rio de Janeiro, que funcionou como laboratório das matrizes curriculares defendidas pela classe empresarial, no momento que precedeu a recente contrarreforma da educação básica, iniciada no âmbito nacional em 2016. Através da pesquisa documental, analisa os elementos de atualização e refuncionalização ideológica, materializados na ênfase conferida às competências socioemocionais e ao empreendedorismo juvenil na legislação e nos documentos normativos de políticas públicas educacionais.
Palavras-chave: Contrarreforma do ensino médio; Juventude; Empreendedorismo
A HISTORICIDADE DAS FORÇAS PRODUTIVAS: UM ESTUDO DO TEMPO PRESENTE EM TRABALHO-EDUCAÇÃO
Authors: Ciavatta Maria
Published: April 2024

São as contradições entre as forças produtivas e as relações sociais de produção que geram a história humana. Temos por base teórica o materialismo histórico, com a crítica à economia política e a história como produção social da existência. Reconhecer sua historicidade implica concebê-las em espaço-tempos determinados, sob a ação dos sujeitos sociais, a totalidade social, suas mediações e contradições. No primeiro momento tratamos da historicidade das forças produtivas; a seguir, da questão da história do presente; e, por último, de questões sobre trabalho-educação na imprensa, de 2020 a 2022.
Palavras-chave: forças produtivas; trabalho-educação, história do presente, imprensa.
NEGACIONISMO E IDEOLOGIA: A ATIVIDADE TEÓRICA NOS PROCESSOS DE CONSCIÊNCIA
Authors: Frizzo Giovanni
Published: April 2024

O objetivo deste texto é analisar a relação entre o negacionismo, entendido como uma expressão ideológica do atual período de crise sistêmica, e a atividade teórica que incide sobre os processos de consciência. O negacionismo articula as manifestações do senso-comum, da mitologia (religião) e da ciência/filosofia em torno de um projeto de dominação no qual o conhecimento crítico da realidade é combatido por uma perspectiva de ultrageneralizações e exacerbação do individualismo.
Palavra-chave: Negacionismo; Ideologia; Consciência.
LEANDRO KONDER: DIALÉTICA E MARXISMO - UM DEBATE DRAMATICAMENTE NECESSÁRIO
Authors: Taffarel Celi , ALBUQUERQUE JOELMA OLIVEIRA
Published: April 2024

Ao rememorar seus 20 anos de publicação, a Revista Trabalho Necessário delimitou como título do Dossiê n. 45 “20 Anos da TN: a produção científica no combate às investidas do capital”, e elegeu o texto Clássico de Leandro Augusto Marques Coelho Konder – A Dialética e o Marxismo, publicado no seu primeiro número em 2003, para ser comentado. Para realizarmos tal tarefa, destacamos os seguintes tópicos: A Revista; O contexto histórico; O Autor; Destaques da sua obra; O texto comentado; A conclusão: a necessidade do debate dramaticamente atual.
Palavras-chave: Dialética, Marxismo, Clássico TN, Filosofia
PRODUÇÃO E CIRCULAÇÃO DE CONHECIMENTO EM TEMPOS DE MERCANTILIZAÇÃO E NEGACIONISMO: DESAFIOS EDITORIAIS
Authors: Barbosa de Oliveira Ines
Published: April 2024

Descobrimos recentemente no Brasil, e algo chocados, que os preços cobrados dos autores, por algumas das principais editoras científicas do mundo beiram os dez mil dólares. Enquanto isso, cresce no mundo, a perspectiva de uma ciência aberta, acessível a todos, transparente em suas avaliações por pares e em relação aos dados das pesquisas que estão na origem dos artigos. Este cenário de embates e contradições nos permite tratar dos desafios editoriais que estão colocados àqueles que atuam na área a partir de diferentes ângulos. O objetivo é contribuir para as reflexões, mais do que oferecer respostas, levantar possibilidades de mudança e apontar dificuldades. Didaticamente separados em seções, os temas se articulam e caminham juntos, como diferentes expressões do momento político, científico e econômico que o mundo ocidental vivencia.

Assim, o artigo aborda, em primeiro lugar, a questão da mercantilização e da influência das desigualdades econômicas sobre a circulação do conhecimento, incluindo no debate as questões que envolvem a ideia do inglês como língua franca na perspectiva da “internacionalização subalterna”. Em seguida, trataremos dos riscos políticos e sociais tanto da exclusão quanto o fato desta exclusão abrir espaço para a desinformação e o negacionismo e seu outro lado, os ataques às universidades e pesquisadores no Brasil.

A especificidade do cenário nacional nas ciências humanas e sociais e as responsabilidades editoriais que a ela se associam fecha o artigo, buscando situar alguns dos principais problemas que nos atingem, considerando não só este cenário global, como as inadequações da compreensão hegemônica de ética na pesquisa – associada ao campo da saúde – e os esforços que vêm sendo feitos para que os resultados de pesquisas no campo respeitem exigências éticas outras e se adequem a princípios mais adequados ao campo.
UMA VOLTA NO TEMPO: DO PRESENTE AO PASSADO, PARA O FUTURO
Authors: Ciavatta Maria
Published: April 2024

MEMÓRIA E DOCUMENTOS me trazem à mente duas questões. Uma delas é a memória e sua existência na vida humana. A outra questão são os documentos. Mia Couto, o escritor moçambicano, nos diz que que existimos enquanto alguém se lembrar de nós, enquanto estivermos na memória. Esta ideia serve para os indivíduos, mas, principalmente, para as instituições com seus coletivos, ideias, interesses diversos e divergências.