bluuebunny/crossref_metadata_2025 huggingface dataset:
Interrelations between Gut Microbiota Composition, Nutrient Intake and Diabetes Status in an Adult Japanese Population
Authors: Tamura Ayumi , Murabayashi Masaya , Nishiya Yuki , Mizushiri Satoru , Hamaura Kiho , Ito Ryoma , Ono Shoma , Terada Akihide , Murakami Hiroshi , Tanabe Jutaro , Yanagimachi Miyuki , Tokuda Itoyo , Sawada Kaori , Ihara Kazushige , Daimon Makoto
Published: June 2022

Upon food digestion, the gut microbiota plays a pivotal role in energy metabolism, thus affecting the development of type 2 diabetes (DM). We aimed to examine the influence of the composition of selected nutrients consumed on the association between the gut microbiota and DM. This cross-sectional study of a general population was conducted on 1019 Japanese volunteers. Compared with non-diabetic subjects, diabetic subjects had larger proportions of the genera Bifidobacterium and Streptococcus but smaller proportions of the genera Roseburia and Blautia in their gut microbiotas. The genera Streptococcus and Roseburia were positively correlated with the amounts of energy (p = 0.027) and carbohydrate and fiber (p = 0.007 and p = 0.010, respectively) consumed, respectively. In contrast, the genera Bifidobacterium and Blautia were not correlated with any of the selected nutrients consumed. Cluster analyses of these four genera revealed that the Blautia-dominant cluster was most negatively associated with DM, whereas the Bifidobacterium-dominant cluster was positively associated with DM (vs. the Blautia-dominant cluster; odds ratio 3.97, 95% confidence interval 1.68–9.35). These results indicate the possible involvement of nutrient factors in the association between the gut microbiota and DM. Furthermore, independent of nutrient factors, having a Bifidobacterium-dominant gut microbiota may be a risk factor for DM compared to having a Blautia-dominant gut microbiota in a general Japanese population.
Pediatric Infective Endocarditis: A Literature Review
Authors: Vicent Lourdes , Luna Raquel , Martínez-Sellés Manuel
Published: June 2022

Infective endocarditis in children is a rare entity that poses multiple challenges. A history of congenital heart disease is the most common risk factor, although in recent years, other emerging predisposing conditions have gained relevance, such as central venous catheters carriers or children with chronic debilitating conditions; cases in previously healthy children with no medical history are also seen. Diagnosis is complex, although it has improved with the use of multimodal imaging techniques. Antibiotic treatment should be started early, according to causative microorganism and risk factors. Complications are frequent and continue to cause significant morbidity. Most studies have been conducted in adults and have been generalized to the pediatric population, with subsequent limitations. Our manuscript presents a comprehensive review of pediatric infective endocarditis, including recent advances in diagnosis and management.
The Impact of Perioperative Fluid Balance on Postoperative Complications after Esophagectomy for Esophageal Cancer
Authors: Kubo Yuto , Tanaka Koji , Yamasaki Makoto , Yamashita Kotaro , Makino Tomoki , Saito Takuro , Yamamoto Kazuyoshi , Takahashi Tsuyoshi , Kurokawa Yukinori , Motoori Masaaki , Kimura Yutaka , Nakajima Kiyokazu , Eguchi Hidetoshi , Doki Yuichiro
Published: June 2022

Background: Perioperative fluid balance is an important indicator in the management of esophageal cancer patients who undergo esophagectomy. However, the association between perioperative fluid balance and postoperative complications after minimally invasive esophagectomy (MIE) remains unclear. Methods: This study included 115 patients with thoracic esophageal squamous cell cancer who underwent MIE between January 2018 and January 2020. We retrospectively evaluated the association between perioperative fluid balance from during surgery to postoperative day (POD) 2, and postoperative complications. Results: The patients were divided into lower group and higher group based on the median fluid balance during surgery and at POD 1 and POD 2. We found that the higher group at POD 1 (≥3000 mL) was the most important indicator of postoperative complications, such as acute pneumonia within 7 days after surgery, and anastomotic leakage (p = 0.029, p = 0.024, respectively). Moreover, the higher group at POD 1 was a significant independent factor for acute postoperative pneumonia by multivariate analysis (OR: 3.270, 95% CI: 1.077–9.929, p = 0.037). Conclusion: This study showed that fluid overload at POD 1 had a negative influence on postoperative complications in patients with esophageal cancer. The fluid balance must be strictly controlled during the early postoperative management of patients undergoing esophageal cancer surgery.
Tips and Details for Successful Robotic Myomectomy: Single-Center Experience with the First 125 Cases
Authors: Dou Lei , Zhang Yi
Published: June 2022

With the continuous development of minimally invasive and precise surgical techniques, laparoscopic myomectomy has become a mainstream surgical method due to its aesthetic outcomes and rapid postoperative recovery. However, during laparoscopic myomectomy, clinicians often encounter unfavorable factors, such as limited vision, inaccurate suturing, difficulty in removing tumors, and susceptibility to fatigue in the operating position. In recent years, robot-assisted surgery has been widely used in gynecology. The advantages of this technique, such as a three-dimensional surgical view, reducing the surgeon’s tremor, and the seven degrees of freedom of the robotic arms, compensate for the defects in laparoscopic surgery. The Department of Gynecology in our hospital has accumulated a wealth of experience since robot-assisted surgery was first carried out in 2017. In this article, the surgical skills of the robotic myomectomy process are described in detail.
Menstrual Cycle Changes Joint Laxity in Females—Differences between Eumenorrhea and Oligomenorrhea
Authors: Maruyama Sae , Sekine Chie , Shagawa Mayuu , Yokota Hirotake , Hirabayashi Ryo , Togashi Ryoya , Yamada Yuki , Hamano Rena , Ito Atsushi , Sato Daisuke , Edama Mutsuaki
Published: June 2022

The purpose of this study was to investigate the changes in anterior knee laxity (AKL), stiffness, general joint laxity (GJL), and genu recurvatum (GR) during the menstrual cycle in female non-athletes and female athletes with normal and irregular menstrual cycles. Participants were 19 female non-athletes (eumenorrhea, n = 11; oligomenorrhea, n = 8) and 15 female athletes (eumenorrhea, n = 8; oligomenorrhea, n = 7). AKL was measured as the amount of anterior tibial displacement at 67 N–133 N. Stiffness was calculated as change in (Δ)force/Δ anterior displacement. The Beighton method was used to evaluate the GJL. The GR was measured as the maximum angle of passive knee joint extension. AKL, stiffness, GJL, and GR were measured twice in four phases during the menstrual cycle. Stiffness was significantly higher in oligomenorrhea groups than in eumenorrhea groups, although no significant differences between menstrual cycle phases were evident in female non-athletes. GR was significantly higher in the late follicular, ovulation, and luteal phases than in the early follicular phase, although no significant differences between groups were seen in female athletes. Estradiol may affect the stiffness of the periarticular muscles in the knee, suggesting that GR in female athletes may change during the menstrual cycle.
Cell-Derived Exosomes as Therapeutic Strategies and Exosome-Derived microRNAs as Biomarkers for Traumatic Brain Injury
Authors: Wang Jing , Wang Junwen , Li Xinyan , Shu Kai
Published: June 2022

Traumatic brain injury (TBI) is a complex, life-threatening condition that causes mortality and disability worldwide. No effective treatment has been clinically verified to date. Achieving effective drug delivery across the blood–brain barrier (BBB) presents a major challenge to therapeutic drug development for TBI. Furthermore, the field of TBI biomarkers is rapidly developing to cope with the many aspects of TBI pathology and enhance clinical management of TBI. Exosomes (Exos) are endogenous extracellular vesicles (EVs) containing various biological materials, including lipids, proteins, microRNAs, and other nucleic acids. Compelling evidence exists that Exos, such as stem cell-derived Exos and even neuron or glial cell-derived Exos, are promising TBI treatment strategies because they pass through the BBB and have the potential to deliver molecules to target lesions. Meanwhile, Exos have decreased safety risks from intravenous injection or orthotopic transplantation of viable cells, such as microvascular occlusion or imbalanced growth of transplanted cells. These unique characteristics also create Exos contents, especially Exos-derived microRNAs, as appealing biomarkers in TBI. In this review, we explore the potential impact of cell-derived Exos and exosome-derived microRNAs on the diagnosis, therapy, and prognosis prediction of TBI. The associated challenges and opportunities are also discussed.
In Vivo Evaluation of 3D-Printed Silica-Based Bioactive Glass Scaffolds for Bone Regeneration
Authors: Tulyaganov Dilshat U. , Fiume Elisa , Akbarov Avzal , Ziyadullaeva Nigora , Murtazaev Saidazim , Rahdar Abbas , Massera Jonathan , Verné Enrica , Baino Francesco
Published: June 2022

Bioactive glasses are often designed as porous implantable templates in which newly-formed bone can grow in three dimensions (3D). This research work aims to investigate the bone regenerative capability of silicate bioactive glass scaffolds produced by robocasting in comparison with powder and granule-like materials (oxide system: 47.5SiO2-10Na2O-10K2O-10MgO-20CaO-2.5P2O5, mol.%). Morphological and compositional analyses performed by scanning electron microscopy (SEM), combined with energy dispersive spectroscopy (EDS) after the bioactivity studies in a simulated body fluid (SBF) confirmed the apatite-forming ability of the scaffolds, which is key to allowing bone-bonding in vivo. The scaffolds exhibited a clear osteogenic effect upon implantation in rabbit femur and underwent gradual resorption followed by ossification. Full resorption in favor of new bone growth was achieved within 6 months. Osseous defect healing was accompanied by the formation of mature bone with abundant osteocytes and bone marrow cells. These in vivo results support the scaffold’s suitability for application in bone tissue engineering and show promise for potential translation to clinical assessment.
Detection and Statistics of Offshore Aquaculture Rafts in Coastal Waters
Authors: Zhou Chen , Wong Kapo , Tsou Jin Yeu , Zhang Yuanzhi
Published: June 2022

Offshore aquaculture is critical for a marine fishery economy. The spatial distribution of aquaculture that characterizes it plays a vital role in the sustainable development of marine resources and the protection of the marine environment. In recent years, China’s aquaculture has developed rapidly; specifically, the scale of aquaculture has dramatically expanded, and large-scale aquaculture has gradually grown in popularity. Although high-resolution satellite data can accurately extract aquaculture areas, the extraction of a large area of the sea area requires a copious amount of data. In contrast, medium-resolution satellite images allow for the extraction of aquaculture areas from large sea areas with a smaller amount of data, offering significant advantages. Therefore, we used Landsat8 satellite data to extract and count the number of aquaculture rafts based on the Hough transform and Canny edge detection methods. We tested the accuracy of this method by selecting Haizhou Bay as the study area for the experiment and accuracy verification and found that the automatic extraction accuracy for the number of aquaculture rafts was more than 90%. Additionally, we calculated statistics on the number of aquaculture rafts in Haizhou Bay over the past seven years. The findings presented in this paper offer a significant reference value for local marine utilization, marine environment protection, and marine disaster prevention and mitigation.
Dental Management of Maxillofacial Ballistic Trauma
Authors: Brauner Edoardo , Laudoni Federico , Amelina Giulia , Cantore Marco , Armida Matteo , Bellizzi Andrea , Pranno Nicola , De Angelis Francesca , Valentini Valentino , Di Carlo Stefano
Published: June 2022

Maxillofacial ballistic trauma represents a devastating functional and aesthetic trauma. The extensive damage to soft and hard tissue is unpredictable, and because of the diversity and the complexity of these traumas, a systematic algorithm is essential. This study attempts to define the best management of maxillofacial ballistic injuries and to describe a standardized, surgical and prosthetic rehabilitation protocol from the first emergency stage up until the complete aesthetic and functional rehabilitation. In low-velocity ballistic injuries (bullet speed <600 m/s), the wound is usually less severe and not-fatal, and the management should be based on early and definitive surgery associated with reconstruction, followed by oral rehabilitation. High-velocity ballistic injuries (bullet speed >600 m/s) are associated with an extensive hard and soft tissue disruption, and the management should be based on a three-stage reconstructive algorithm: debridement and fixation, reconstruction, and final revision. Rehabilitating a patient with ballistic trauma is a multi-step challenging treatment procedure that requires a long time and a multidisciplinary team to ensure successful results. The prosthodontic treatment outcome is one of the most important parameters by which a patient measures the restoration of aesthetic, functional, and psychological deficits. This study is a retrospective review: twenty-two patients diagnosed with outcomes of ballistic traumas were identified from the department database, and eleven patients met the inclusion criteria and were enrolled.
Reclaiming Wetlands after Oil Sands Mining in Alberta, Canada: The Changing Vegetation Regime at an Experimental Wetland
Authors: House Melissa , Vitt Dale H. , Glaeser Lilyan C. , Hartsock Jeremy A.
Published: June 2022

Surface mining for oil sand results in the formation of large pits that must be reclaimed. Some of these pits are backfilled with a myriad of substrates, including tailings rich in cations and anions, to form a solid surface. Experimental reclamation of the East in-pit located on the Syncrude Canada Ltd. mine lease was initiated in 2011 with Sandhill Wetland. Here, we report on monitoring (between 2015 and 2021) of Sandhill Wetland plant communities and significant environmental features, including base cations and water tables. Multivariate analyses demonstrated that the three dominant plant communities established in 2013 have continued to be dominated by the same species nine years after reclamation was initiated, but with reduced species richness. Plant communities have shifted across the wetland in response to water table changes and increases in sodium concentrations. The stoichiometry of base cations is unlike the natural wetlands of the region, and the surficial water chemistry of the wetland is unique. In response to variability in precipitation events coupled with wetland design, water tables have been highly variable, creating shifting water regimes across the wetland. Plant community responses to these shifting conditions, along with increases in base cation concentrations, especially sodium, provide background data for future in-pit reclamation designs. The plant responses underscore the need to develop reclamation designs for landscapes disturbed by mining that alleviate extreme water table fluctuation events and decrease cation concentrations to levels that approach natural wetlands.
Corn and Wheat Residue Management Effects on Greenhouse Gas Emissions in the Mid-Atlantic USA
Authors: Battaglia Martin L. , Thomason Wade E. , Fike John H. , Evanylo Gregory K. , Stewart Ryan D. , Gross Cole D. , Seleiman Mahmoud F. , Babur Emre , Sadeghpour Amir , Harrison Matthew Tom
Published: June 2022

Greenhouse gas (GHG) emissions from crop residue management have been studied extensively, yet the effects of harvesting more than one crop residue in a rotation have not been reported. Here, we measured the short-term changes in methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2) emissions in response to residue removal from continuous corn (Zea mays L.) (CC) and corn–wheat (Triticum aestivum L.)–soybean (Glycine max L. Merr.) (CWS) rotations in the Mid-Atlantic USA. A first experiment retained five corn stover rates (0, 3.33, 6.66, 10, and 20 Mg ha−1) in a continuous corn (CC) in Blacksburg, VA, in 2016 and 2017. Two other experiments, initiated during the wheat and corn phases of the CWS rotation in New Kent, VA, utilized a factorial combination of retained corn (0, 3.33, 6.66, and 10.0 Mg ha−1) and wheat residue (0, 1, 2, and 3 Mg ha−1). Soybean residue was not varied. Different crop retention rates did not affect CO2 fluxes in any of the field studies. In Blacksburg, retaining 5 Mg ha−1 stover or more increased CH4 and N2O emissions by ~25%. Maximum CH4 and N2O fluxes (4.16 and 5.94 mg m−2 day−1) occurred with 200% (20 Mg ha−1) retention. Two cycles of stover management in Blacksburg, and one cycle of corn or wheat residue management in New Kent did not affect GHG fluxes. This study is the first to investigate the effects of crop residue on GHG emissions in a multi-crop system in humid temperate zones. Longer-term studies are warranted to understand crop residue management effects on GHG emissions in these systems.
Efficiency Analysis of Land Use and the Degree of Coupling Link between Population Growth and Global Built-Up Area in the Subregion of West Africa
Authors: Faye Bonoua , Du Guoming , Zhang Ru
Published: June 2022

The main challenge for land use efficiency is population growth. Using a coupling coordination model and the Sustainable Development Goal 11.3.1 (Land Consumption Rate to Population Growth Rate, LCRPGR), the present study unravels the evolution of land use types and efficiency of land use in the Economic Community of West African States (ECOWAS) from 2003 to 2019. We interpreted the temporal land use types based on the long-time series Moderate Resolution Imaging Spectroradiometer (MCD12Q1-V6) land use images in 2003, 2007, 2011, 2015, and 2019. The World Bank data on population and socioeconomics were used to support the investigation on the coupled link. Our results showed that from 2003 to 2019, the total area of agricultural land decreased by −1.4%, while the built-up area expanded by 25.80%. Globally, the LCRPGR was 0.82, of which Cabo-Verdi and Niger had the highest (1.69) and lowest index (0.58), respectively. Correspondingly, the coupled coordination model indicated an overall value of 6.81, in which the highest and lowest value occurred in Liberia (29.78) and Niger (0.31), respectively. Furthermore, a rapidly growing population had become one of the most important factors causing inefficient land use in the study area. In summary, the ECOWAS was confronted with a lack of management to improve land use efficiency. Thus, future land use policies should pay more attention to balancing the coupled relationship between urban expansion and socio-economic interests.
Spatiotemporal Characteristics of Rural Restructuring Evolution and Driving Forces in Mountainous and Hilly Areas
Authors: Zhou Lulu , Wang Li , Su Kangchuan , Bi Guohua , Chen Hongji , Liu Xiaoyu , Yang Qingyuan
Published: June 2022

Rural restructuring is an effective means to boost rural revitalization. Research on rural restructuring and its driving forces is helpful to adjust the evolution direction of key development factors, and form a coupling and coordinated development pattern. Taking Chongqing as an example, this paper adopts basic geographic data, land use data, and social and economic data, and uses the entropy method, spatial econometric model, and GTWR model. The paper explores the spatiotemporal evolution pattern of influencing factors on rural restructuring from 2000 to 2018 from the perspective of exogenous driving and endogenous driving. The results show the following. (1) During the study period, the average values of the rural economic restructuring intensity index, social restructuring intensity index, spatial restructuring intensity index, and comprehensive restructuring intensity index were 0.138, 0.118, 0.123, and 0.379, respectively. During the research period, rural restructuring in Chongqing experienced four development stages: space-economic restructuring-led, economic-social restructuring-led, economic restructuring-led, and social-spatial restructuring-led. In general, the dominant speed of economic restructuring gradually accelerated, and the changes in spatial restructuring were obvious but still lagging. Compared with other periods, the characteristics of social restructuring and spatial restructuring were more obvious between 2015 and 2018. (2) Different types of rural restructuring were affected by exogenous and endogenous factors. Exogenous driving mainly showed a negative impact on the changes in rural restructuring in the study area, while endogenous driving mainly showed a positive impact. (3) The driving system composed of exogenous driving and endogenous driving showed obvious timing and dynamic fluctuation. From 2000 to 2005 and from 2015 to 2018, rural restructuring in the study area was balanced and driven by endogenous and exogenous factors. From 2005 to 2015, rural restructuring in the study area was dominated by exogenous driving. Based on the influence differences and internal correlations of the driving forces of rural restructuring, policy opinions are put forward from the two aspects of restructuring path and restructuring guarantee, which provide a scientific basis for the determination of rural development direction and path selection.
Identification and Spatial-Temporal Variation Characteristics of Regional Drought Processes in China
Authors: Cai Xiuhua , Zhang Wenqian , Zhang Cunjie , Zhang Qiang , Sun Jingli , Cheng Chen , Fan Wenjie , Yu Ying , Liu Xiaoling
Published: June 2022

Based on the daily temperature and precipitation data from 1961 to 2021 obtained from 2019 national meteorological stations of China, and by means of Meteorological Drought Comprehensive Index (MCI) and some improved identification methods, we identified all drought event processes in all the seven regions of China in this paper. We also carefully analyzed these regional droughts and made following conclusions: drought was spreading towards southern China with an increasing frequency; consecutive drought year group occurred in all the seven regions of China with an increasing frequency under the background of global warming; both drought duration and comprehensive intensity consistently changed with the area affected by drought, with a correlation coefficient of 0.52–0.67 and 0.88–0.99 respectively, and passed the significance test of 0.05. The method used in this paper could be employed to effectively monitor and evaluate drought processes from multiple dimensions including duration, comprehensive intensity and area affected by drought. Thus, it actually provided a helpful decision-making basis for governments to prevent the risk of drought.
The Role of Macronutrients in the Pathogenesis, Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Paediatric Population—A Review
Authors: Pixner Thomas , Stummer Nathalie , Schneider Anna Maria , Lukas Andreas , Gramlinger Karin , Julian Valérie , Thivel David , Mörwald Katharina , Maruszczak Katharina , Mangge Harald , Gomahr Julian , Weghuber Daniel , Furthner Dieter
Published: June 2022

Paediatric non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in childhood. Obesity is the main risk factor. Nutrition and lifestyle are the key elements in preventing and treating NAFLD in the absence of approved drug therapy. Whilst recommendations and studies on macronutrients (carbohydrates, fat and protein) in adult NAFLD exist, the discussion of this topic in paediatric NAFLD remains contradictory. The purpose of this review is to provide state-of-the-art knowledge on the role of macronutrients in paediatric NAFLD regarding quality and quantity. PubMed was searched and original studies and review articles were included in this review. Fructose, sucrose, saturated fatty acids, trans-fatty acids and ω-6-fatty-acids are strongly associated with paediatric NAFLD. High consumption of fibre, diets with a low glycaemic index, mono-unsaturated-fatty-acids and ω-3-fatty-acids reduce the risk of childhood-onset NAFLD. Data regarding the role of dietary protein in NAFLD are contradictory. No single diet is superior in treating paediatric NAFLD, although the composition of macronutrients in the Mediterranean Diet appears beneficial. Moreover, the optimal proportions of total macronutrients in the diet of paediatric NAFLD patients are unknown. Maintaining a eucaloric diet and avoiding saturated fatty acids, simple sugars (mainly fructose) and a high-caloric Western Diet are supported by literature.
Research on the Mechanism of the Stiffness Performance of Rolling Bearings under Wrong Assembly State
Authors: Zhang Yanfei , Li Yunhao , Kong Lingfei , Yang Zhenchao , Si Yue
Published: June 2022

In this paper, a quasi-static angular contact ball bearing model, considering assembly accuracy is constructed, while a numerical solution method for bearing stiffness under bad assembly state is established. A 7014C angular contact ball bearing is used as the research object and five groups of different spacer inclinations are designed to imitate the installation error of the spindle bearing. The bearing stiffness performance was comparatively analyzed, according to the five spacers. The effect of preload and rotation speed on bearing stiffness are systematically investigated, considering different parallelism errors, as induced by the spacers. The influence mechanism of the badly assembled bearing on the respective stiffness anisotropy is studied based on the proposed model. The results show that the variations of the inclination between the inner and outer rings of the bearing exhibit a very weak effect on the axial stiffness, while the influence on the radial and angular stiffness is more significant.
Synthesis and Characterization of Fluorite-Type La2Ce2O7 Plasma Sprayable Powder for TBCs Application
Authors: Parchovianská Ivana , Parchovianský Milan , Pecušová Beáta , Hanzel Ondrej , Pakseresht Amirhossein
Published: June 2022

This work focuses on the fabrication of lanthanum cerate (La2Ce2O7, LC) powders via two chemical routes: modified Pechini sol-gel method and solid-state synthesis. The synthesized LC powders were heat treated in the temperature range of 1000–1400 °C for 6 h and investigated as a material for thermal barrier coating (TBC) applications. For this purpose, the powder morphology, chemical composition, crystal structure and thermal stability were studied. Scanning electron microscopy (SEM) of the synthesized powders revealed an agglomerated structure consisting of fine and uniformly distributed grains. Energy-dispersive X-ray spectroscopy (EDXS) indicated that the chemical compositions of the LC powders were similar to the stoichiometric ratio of La2Ce2O7. A cubic fluorite structure was observed by X-ray diffraction analysis (XRD) after calcining the LC powder prepared by solid-state synthesis at 1300 °C. In contrast, there was always a fluorite structure in the LC powder synthesized by the Pechini sol-gel method after heat treatment over the entire temperature range. The thermal behavior of the LC powders was analyzed by differential scanning calorimetry (DSC) and thermogravimetric analysis (TG) in the temperature range of 25–1300 °C. Neither an obvious mass change nor a visible energy change was observed within the tested temperature range, indicating high phase stability of the LC powder and its suitability for TBC applications. Spheroidization on the prepared LC powders was also investigated, revealing that powder size and morphology had a significant impact on the spheroidization efficiency.
Microwave-Assisted Solvothermal Synthesis of Nanocrystallite-Derived Magnetite Spheres
Authors: Zambzickaite Greta , Talaikis Martynas , Dobilas Jorunas , Stankevic Voitech , Drabavicius Audrius , Niaura Gediminas , Mikoliunaite Lina
Published: June 2022

The synthesis of magnetic particles triggers the interest of many scientists due to their relevant properties and wide range of applications in the catalysis, nanomedicine, biosensing and magnetic separation fields. A fast synthesis of iron oxide magnetic particles using an eco-friendly and facile microwave-assisted solvothermal method is presented in this study. Submicron Fe3O4 spheres were prepared using FeCl3 as an iron source, ethylene glycol as a solvent and reductor and sodium acetate as a precipitating and nucleating agent. The influence of the presence of polyethylene glycol as an additional reductor and heat absorbent was also evaluated. We reduce the synthesis time to 1 min by increasing the reaction temperature using the microwave-assisted solvothermal synthesis method under pressure or by adding PEG at lower temperatures. The obtained magnetite spheres are 200–300 nm in size and are composed of 10–30 nm sized crystallites. The synthesized particles were investigated using the XRD, TGA, pulsed-field magnetometry, Raman and FTIR methods. It was determined that adding PEG results in spheres with mixed magnetite and maghemite compositions, and the synthesis time increases the size of the crystallites. The presented results provide insights into the microwave-assisted solvothermal synthesis method and ensure a fast route to obtaining spherical magnetic particles composed of different sized nanocrystallites.
Kinetics and Adsorption Isotherms of Amine-Functionalized Magnesium Ferrite Produced Using Sol-Gel Method for Treatment of Heavy Metals in Wastewater
Authors: Irfan Muhammad , Zaheer Fareeda , Hussain Humaira , Naz Muhammad Yasin , Shukrullah Shazia , Legutko Stanislaw , Mahnashi Mater H. , Alsaiari Mabkhoot A. , Ghanim Abdulnour Ali Jazem , Rahman Saifur , Alshorman Omar , Alkahtani Fahad Salem , Khan Mohammad K. A. , Kruszelnicka Izabela , Ginter-Kramarczyk Dobrochna
Published: June 2022

This study is focused on the kinetics and adsorption isotherms of amine-functionalized magnesium ferrite (MgFe2O4) for treating the heavy metals in wastewater. A sol-gel route was adopted to produce MgFe2O4 nanoparticles. The surfaces of the MgFe2O4 nanoparticles were functionalized using primary amine (ethanolamine). The surface morphology, phase formation, and functionality of the MgFe2O4 nano-adsorbents were studied using the SEM, UV-visible, FTIR, and TGA techniques. The characterized nanoparticles were tested on their ability to adsorb the Pb2+, Cu2+, and Zn2+ ions from the wastewater. The kinetic parameters and adsorption isotherms for the adsorption of the metal ions by the amine-functionalized MgFe2O4 were obtained using the pseudo-first-order, pseudo-second-order, Langmuir, and Freundlich models. The pseudo-second order and Langmuir models best described the adsorption kinetics and isotherms, implying strong chemisorption via the formation of coordinative bonds between the amine groups and metal ions. The Langmuir equation revealed the highest adsorption capacity of 0.7 mmol/g for the amine-functionalized MgFe2O4 nano-adsorbents. The adsorption capacity of the nanoadsorbent also changed with the calcination temperature. The MgFe2O4 sample, calcined at 500 °C, removed the most of the Pb2+ (73%), Cu2+ (59%), and Zn2+ (62%) ions from the water.
Investigation of Friction and Wear Behavior of Cast Aluminum Alloy Piston Skirt with Graphite Coating Using a Designed Piston Skirt Test Apparatus
Authors: Teng Dezhi , Wang Jingsi , Li Chengdi , Sa Xiaoxia
Published: June 2022

A piston skirt friction and wear apparatus that simulates the contact and the relative motion of piston and cylinder liner in a real engine has been designed and constructed. With this apparatus, the friction and wear behavior of a cast aluminum alloy piston with a graphite coating under different loads was studied, and the effectiveness of the apparatus was confirmed. The total wear of the piston skirt was higher under a higher load, and the upper part of the skirt surface (around the height of the piston pin) was worn more severely. The wear mechanisms were studied and, based on the test results and surface analyses, three main wear modes were believed to occur in the wear process of the piston skirt: abrasive, adhesive, and fatigue wear. The effects of skirt profile design, coating, and surface texturing on the friction and wear behavior of the piston skirt can be investigated well using the proposed apparatus, which can truly reflect actual working conditions and is useful to improve the tribological performances of piston skirts.
Load-to-Failure Resistance and Optical Characteristics of Nano-Lithium Disilicate Ceramic after Different Aging Processes
Authors: Donmez Mustafa Borga , Olcay Emin Orkun , Demirel Münir
Published: June 2022

The aim of this study was to compare the load-to-failure resistance and optical properties of nano-lithium disilicate (NLD) with lithium disilicate (LDS) and zirconia-reinforced lithium silicate (ZLS) in different aging processes. Thirty crowns were milled from NLD, LDS, and ZLS (n = 10). All crowns were subjected to thermomechanical aging and loaded until catastrophic failure. Ten specimens from each material were prepared in two different thicknesses (0.7 mm and 1.5 mm, n = 5), and color coordinates were measured before and after coffee thermocycling. Color differences (ΔE00) and relative translucency parameter (RTP) were calculated. Data were analyzed by using ANOVA and Bonferroni-corrected t-tests (α = 0.05). ZLS had the highest load-to-failure resistance (p ≤ 0.002), while the difference between LDS and NLD was nonsignificant (p = 0.776). The interaction between material type and thickness affected ΔE00 (p < 0.001). Among the 0.7 mm thick specimens, ZLS had the lowest ΔE00 (p < 0.001). Furthermore, 1.5 mm thick ZLS had lower ΔE00 than that of 1.5 mm thick LDS (p = 0.036). Other than ZLS (p = 0.078), 0.7 mm thick specimens had higher ΔE00 (p < 0.001). The interaction between material type, thickness, and thermocycling affected RTP (p < 0.001). Thinner specimens presented higher RTP (p < 0.001). NLD and LDS had higher RTP than ZLS (p ≤ 0.036). However, 0.7 mm thick specimens had similar RTP after coffee thermocycling (p ≥ 0.265). Coffee thermocycling reduced the RTP values of 0.7 mm thick NLD (p = 0.032) and LDS (p = 0.008). NLD may endure the occlusal forces present in the posterior region. However, long-term coffee consumption may impair the esthetics of restorations particularly when thin NLD is used.
Bio-Alcohol Sensor Based on One-Dimensional Photonic Crystals for Detection of Organic Materials in Wastewater
Authors: Al-Dossari M. , Awasthi S. , Mohamed A. , Abd El-Gawaad N. , Sabra W. , Aly Arafa
Published: June 2022

In this work, we have explored a novel application of one–dimensional (1D) photonic crystals (PCs) as a biomarker for the detection of organic materials in wastewater. The high concentration of organic materials may lead to adverse impact on human life. In order to save human life from these adverse effects, we have investigated the bio-alcohol sensing properties of a 1D multilayer periodic structure (AB)N/C/(AB)N capable of detecting organic materials in wastewater. The proposed structure works on the principle to detect a very small change in the refractive index of the wastewater sample under investigation by means of producing a shift in the position of the defect mode inside the photonic band gap (PBG) of the proposed structure. The transfer matrix method (TMM) has been used to investigate the transmission properties of the proposed design with the help of MATLAB software. We have also studied the effect of changes in the defect layer’s thickness, the volume fraction of the nanocomposite material and the incident angle on the sensitivity of our proposed bio-alcohol sensing design. Our bio-alcohol sensor shows a high sensitivity value of 500 nm/RIU and a low detection limit value of 1 × 10−5 RIU. The figure of merit and quality factor values of our bio-alcohol sensor are 5 × 103 and 5.236 × 103, respectively. The damping rate of the design is ξ=95.4927×10−5.
Multidisciplinary Collaborative Design and Optimization of Turbine Rotors Considering Aleatory and Interval Mixed Uncertainty under a SORA Framework
Authors: Yuan Rong , Li Haiqing , Xie Tianwen , Lv Zhiyuan , Meng Debiao , Yang Wenke
Published: June 2022

The turbine rotor is the key component of the turbine, which has a great impact on the construction cost and power generation efficiency of an entire hydropower station. Receiving the torque of the runner transmission and completing the specified power generation is its main function. There are many uncertain factors in the design, manufacture, and operation environment of a turbine rotor. Therefore, it is necessary to optimize the mechanism on the premise of ensuring that the mechanical system meets high reliability and high safety levels. This article uses the multidisciplinary reliability analysis and optimization method under random and interval uncertainty to quantitatively analyze the uncertainty factors, and then optimally solves the RBMDO problem of the turbine rotor mechanism. Through the finite element simulation analysis of the optimized design scheme, the rationality and feasibility of the obtained results are further verified.
An Improved Residual-Based Detection Method for Stealthy Anomalies on Mobile Robots
Authors: Yang Biao , Xin Liang , Long Zhiqiang
Published: June 2022

With the expansion of the cyber-physical system (CPS) application area, its importance has become more and more prominent. As one of the typical applications of CPS, the anomaly detections of mobile robots have attracted the attention of all parties. As part of the CPS, mobile robots face the problem that conventional residual-based detection methods cannot identify stealthy anomalies. The conventional residual-based detection methods mainly use the residual signal calculated from the control signal and measure output for detection, which is widely used in fault diagnosis. Still, it is difficult to be useful in deceptive stealthy anomalies purposefully imposed on mobile robots, which are designed to evade the conventional detections by tampering with measure output. Furthermore, they can control the system to deviate from the expected operations, causing degradation of control performance or even damage without being detected. Based on this, by analyzing the system model of CPS and the stealthy conditions of anomalies, the improved residual-based detection method is proposed in this paper. Moreover, three stealthy anomalies purposefully imposed on an omnidirectional mobile robot (OMR) are detected by using the conventional residual-based methods and the improved residual-based method. Finally, the experimental results show that the method proposed can effectively detect the stealthy anomalies purposefully imposed on the OMR.
Deep Learning Approaches for the Segmentation of Glomeruli in Kidney Histopathological Images
Authors: Dimitri Giovanna Maria , Andreini Paolo , Bonechi Simone , Bianchini Monica , Mecocci Alessandro , Scarselli Franco , Zacchi Alberto , Garosi Guido , Marcuzzo Thomas , Tripodi Sergio Antonio
Published: June 2022

Deep learning is widely applied in bioinformatics and biomedical imaging, due to its ability to perform various clinical tasks automatically and accurately. In particular, the application of deep learning techniques for the automatic identification of glomeruli in histopathological kidney images can play a fundamental role, offering a valid decision support system tool for the automatic evaluation of the Karpinski metric. This will help clinicians in detecting the presence of sclerotic glomeruli in order to decide whether the kidney is transplantable or not. In this work, we implemented a deep learning framework to identify and segment sclerotic and non-sclerotic glomeruli from scanned Whole Slide Images (WSIs) of human kidney biopsies. The experiments were conducted on a new dataset collected by both the Siena and Trieste hospitals. The images were segmented using the DeepLab V2 model, with a pre-trained ResNet101 encoder, applied to 512 × 512 patches extracted from the original WSIs. The results obtained are promising and show a good performance in the segmentation task and a good generalization capacity, despite the different coloring and typology of the histopathological images. Moreover, we present a novel use of the CD10 staining procedure, which gives promising results when applied to the segmentation of sclerotic glomeruli in kidney tissues.
Stability of Quartic Functional Equation in Modular Spaces via Hyers and Fixed-Point Methods
Authors: Mohiuddine Syed Abdul , Tamilvanan Kandhasamy , Mursaleen Mohammad , Alotaibi Trad
Published: June 2022

In this work, we introduce a new type of generalised quartic functional equation and obtain the general solution. We then investigate the stability results by using the Hyers method in modular space for quartic functional equations without using the Fatou property, without using the Δb-condition and without using both the Δb-condition and the Fatou property. Moreover, we investigate the stability results for this functional equation with the help of a fixed-point technique involving the idea of the Fatou property in modular spaces. Furthermore, a suitable counter example is also demonstrated to prove the non-stability of a singular case.
Design and Operation of Multipurpose Production Facilities Using Solar Energy Sources for Heat Integration Sustainable Strategies
Authors: Simão Pedro , Vieira Miguel , Pinto Telmo , Pinto-Varela Tânia
Published: June 2022

Industrial production facilities have been facing the requirement to optimise resource efficiency, while considering sustainable goals. This paper addresses the introduction of renewable energies in production by exploring the combined design and scheduling of a multipurpose batch facility, with innovative consideration of direct/indirect heat integration using a solar energy source for thermal energy storage. A mixed-integer linear programming model is formulated to support decisions on scheduling and design selection of storage and processing units, heat exchange components, collector systems, and energy storage units. The results show the minimisation of utilities consumption, with an increase in the operational profit using combined heat integration strategies for the production schedule. A set of illustrative case-study examples highlight the advantages of the solar-based heat storage integration, assessing optimal decision support in the strategic and operational management of these facilities.
Supplements Related to Normal π-Projective Hypermodules
Authors: Nişancı Türkmen Burcu Nişancı , Bordbar Hashem , Cristea Irina
Published: June 2022

In this study, the role of supplements in Krasner hypermodules is examined and related to normal π-projectivity. We prove that the class of supplemented Krasner hypermodules is closed under finite sums and under quotients. Moreover, we give characterizations of finitely generated supplemented and amply supplemented Krasner hypermodules. In the second part of the paper we relate the normal projectivity to direct summands and supplements in Krasner hypermodules.
An Update on the Chemokine System in the Development of NAFLD
Authors: Nagata Naoto , Chen Guanliang , Xu Liang , Ando Hitoshi
Published: June 2022

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Sustained hepatic inflammation is a key driver of the transition from simple fatty liver to nonalcoholic steatohepatitis (NASH), the more aggressive form of NAFLD. Hepatic inflammation is orchestrated by chemokines, a family of chemoattractant cytokines that are produced by hepatocytes, Kupffer cells (liver resident macrophages), hepatic stellate cells, endothelial cells, and vascular smooth muscle cells. Over the last three decades, accumulating evidence from both clinical and experimental investigations demonstrated that chemokines and their receptors are increased in the livers of NAFLD patients and that CC chemokine ligand (CCL) 2 and CCL5 in particular play a pivotal role in inducing insulin resistance, steatosis, inflammation, and fibrosis in liver disease. Cenicriviroc (CVC), a dual antagonist of these chemokines’ receptors, CCR2 and CCR5, has been tested in clinical trials in patients with NASH-associated liver fibrosis. Additionally, recent studies revealed that other chemokines, such as CCL3, CCL25, CX3C chemokine ligand 1 (CX3CL1), CXC chemokine ligand 1 (CXCL1), and CXCL16, can also contribute to the pathogenesis of NAFLD. Here, we review recent updates on the roles of chemokines in the development of NAFLD and their blockade as a potential therapeutic approach.
The Use of Chitosan-Coated Nanovesicles in Repairing Alcohol-Induced Damage of Liver Cells in Mice
Authors: Hilițanu Loredana Nicoleta , Mititelu-Tarțău Liliana , Bogdan Maria , Buca Beatrice Rozalina , Păuna Ana-Maria Raluca , Pavel Liliana Lăcrămioara , Pelin Ana-Maria , Meca Andreea-Daniela , Popa Grațiela Eliza
Published: June 2022

Background and Objectives In the past few decades, the studies concerning the natural polysaccharide chitosan have been centered on a new direction: its hepatoprotective action. The aim of our study was to evaluate the influence of previously designed chitosan lipid vesicles on the liver damage induced by alcohol consumption in mice. Materials and Methods The study involved the oral administration of substances in one daily dose as follows: Group 1 (control): water; Group 2 (control alcohol): 5% alcohol in water; Group 3 (CHIT): 0.1 mL/10 g body weight chitosan solution in animals treated with alcohol; Group 4 (CHIT-ves): 0.1 mL/10 g body chitosan vesicles in animals treated with alcohol; Group 5 (AcA): 200 mg/kg body ascorbic acid in animals treated with alcohol. In order to evaluate liver damage after alcohol consumption, the following hematological parameters were tested: the activity of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase; serum values of urea and creatinine; the phagocytic capacity of polymorphonuclear neutrophilsin peripheral blood;serum opsonic capacity;bactericidal capacity of peritoneal macrophages; and the activity of malondialdehyde, glutathione peroxidase, superoxide dismutase and lactate dehydrogenase. Results and Conclusions The treatment with chitosan vesicles decreased liver enzyme activity and reduced the oxidative stress disturbances in alcoholic mice, thus repairing the hepatic functional and structural damages. These beneficial activities of chitosan vesicles were comparable with ascorbic acid effects in alcoholic mice.