bluuebunny/crossref_metadata_2025 huggingface dataset:
Risikoepidemiologie und Kinderschutzstatistik in der frühen Kindheit: Eine Pilotuntersuchung mit dem „Wahrnehmungsbogen für den Kinderschutz“
Authors: Thurn Leonore , Besier Tanja , Ziegenhain Ute , Jud Andreas , Kindler Heinz , Fischer Dieter , Fegert Jörg M. , Künster Anne Katrin
Published: July 2016

Zusammenfassung. Fragestellung: Bislang liegen in Deutschland weder empirisch ausreichend abgesicherte Prävalenzdaten bezüglich Kindesvernachlässigung und -misshandlung noch in Bezug auf Risikoindikatoren für potenzielle Vernachlässigung oder Misshandlung vor. Methodik: Ziel der Studie war es, ein Verfahren zur systematischen Datenerhebung von Anhaltspunkten für Kindesvernachlässigung und -misshandlung in Kindergärten zu erproben und erste Prävalenzdaten zu generieren. Dazu wurde in 35 Kindergärten eines baden-württembergischen Flächenlandkreises der eigens entwickelte Wahrnehmungsbogen für den Kinderschutz (ESM1 und ESM2) zur Erfassung von Anhaltspunkten für Kindesvernachlässigung und -misshandlung und Risikoindikatoren eingesetzt. Erzieherinnen und Erzieher beurteilten 1122 Kinder zwischen 4 und unter 7 Jahren mithilfe des Wahrnehmungsbogens und des Stärken- und Schwächen-Fragebogens (SDQ). Ergebnisse: Anhaltspunkte für eine Kindesvernachlässigung bzw. -misshandlung wurden bei 13.2 %, Risikoindikatoren bei 38.4 % der Kinder angegeben. Schlussfolgerungen: Systematische Datenerhebungen für den Kinderschutz sind in deutschen Kindergärten machbar und können zur Erhellung des Dunkelfelds beitragen. Künftig sollten lokale Kinderschutznetzwerke auf Grundlage solcher empirischer Untersuchungen adaptiert werden.
Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma
Authors: Chahal Harvind S. , Lin Yuan , Ransohoff Katherine J. , Hinds David A. , Wu Wenting , Dai Hong-Ji , Qureshi Abrar A. , Li Wen-Qing , Kraft Peter , Tang Jean Y. , Han Jiali , Sarin Kavita Y.
Published: July 2016

Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous cell carcinoma remain largely unknown. Here we report the results of a two-stage genome-wide association study of cutaneous squamous cell carcinoma, totalling 7,404 cases and 292,076 controls. Eleven loci reached genome-wide significance (P<5 × 10−8) including seven previously confirmed pigmentation-related loci: MC1R, ASIP, TYR, SLC45A2, OCA2, IRF4 and BNC2. We identify an additional four susceptibility loci: 11q23.3 CADM1, a metastasis suppressor gene involved in modifying tumour interaction with cell-mediated immunity; 2p22.3; 7p21.1 AHR, the dioxin receptor involved in anti-apoptotic pathways and melanoma progression; and 9q34.3 SEC16A, a putative oncogene with roles in secretion and cellular proliferation. These susceptibility loci provide deeper insight into the pathogenesis of squamous cell carcinoma.
High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo
Authors: Koechlein Claire S. , Harris Jeffrey R. , Lee Timothy K. , Weeks Joi , Fox Raymond G. , Zimdahl Bryan , Ito Takahiro , Blevins Allen , Jung Seung-Hye , Chute John P. , Chourasia Amit , Covert Markus W. , Reya Tannishtha
Published: July 2016

Although we know a great deal about the phenotype and function of haematopoietic stem/progenitor cells, a major challenge has been mapping their dynamic behaviour within living systems. Here we describe a strategy to image cells in vivo with high spatial and temporal resolution, and quantify their interactions using a high-throughput computational approach. Using these tools, and a new Msi2 reporter model, we show that haematopoietic stem/progenitor cells display preferential spatial affinity for contacting the vascular niche, and a temporal affinity for making stable associations with these cells. These preferences are markedly diminished as cells mature, suggesting that programs that control differentiation state are key determinants of spatiotemporal behaviour, and thus dictate the signals a cell receives from specific microenvironmental domains. These collectively demonstrate that high-resolution imaging coupled with computational analysis can provide new biological insight, and may in the long term enable creation of a dynamic atlas of cells within their native microenvironment.
Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
Authors: Baptista Marisa A. P. , Keszei Marton , Oliveira Mariana , Sunahara Karen K. S. , Andersson John , Dahlberg Carin I. M. , Worth Austen J. , Liedén Agne , Kuo I-Chun , Wallin Robert P. A. , Snapper Scott B. , Eidsmo Liv , Scheynius Annika , Karlsson Mikael C. I. , Bouma Gerben , Burns Siobhan O. , Forsell Mattias N. E. , Thrasher Adrian J. , Nylén Susanne , Westerberg Lisa S.
Published: July 2016

Wiskott–Aldrich syndrome (WAS) is caused by loss-of-function mutations in the WASp gene. Decreased cellular responses in WASp-deficient cells have been interpreted to mean that WASp directly regulates these responses in WASp-sufficient cells. Here, we identify an exception to this concept and show that WASp-deficient dendritic cells have increased activation of Rac2 that support cross-presentation to CD8+ T cells. Using two different skin pathology models, WASp-deficient mice show an accumulation of dendritic cells in the skin and increased expansion of IFNγ-producing CD8+ T cells in the draining lymph node and spleen. Specific deletion of WASp in dendritic cells leads to marked expansion of CD8+ T cells at the expense of CD4+ T cells. WASp-deficient dendritic cells induce increased cross-presentation to CD8+ T cells by activating Rac2 that maintains a near neutral pH of phagosomes. Our data reveals an intricate balance between activation of WASp and Rac2 signalling pathways in dendritic cells.
Molecular-scale dynamics of light-induced spin cross-over in a two-dimensional layer
Authors: Bairagi Kaushik , Iasco Olga , Bellec Amandine , Kartsev Alexey , Li Dongzhe , Lagoute Jérôme , Chacon Cyril , Girard Yann , Rousset Sylvie , Miserque Frédéric , Dappe Yannick J , Smogunov Alexander , Barreteau Cyrille , Boillot Marie-Laure , Mallah Talal , Repain Vincent
Published: July 2016

Spin cross-over molecules show the unique ability to switch between two spin states when submitted to external stimuli such as temperature, light or voltage. If controlled at the molecular scale, such switches would be of great interest for the development of genuine molecular devices in spintronics, sensing and for nanomechanics. Unfortunately, up to now, little is known on the behaviour of spin cross-over molecules organized in two dimensions and their ability to show cooperative transformation. Here we demonstrate that a combination of scanning tunnelling microscopy measurements and ab initio calculations allows discriminating unambiguously between both states by local vibrational spectroscopy. We also show that a single layer of spin cross-over molecules in contact with a metallic surface displays light-induced collective processes between two ordered mixed spin-state phases with two distinct timescale dynamics. These results open a way to molecular scale control of two-dimensional spin cross-over layers.
Room temperature manipulation of long lifetime spins in metallic-like carbon nanospheres
Authors: Náfrádi Bálint , Choucair Mohammad , Dinse Klaus-Peter , Forró László
Published: July 2016

The time-window for processing electron spin information (spintronics) in solid-state quantum electronic devices is determined by the spin–lattice and spin–spin relaxation times of electrons. Minimizing the effects of spin–orbit coupling and the local magnetic contributions of neighbouring atoms on spin–lattice and spin–spin relaxation times at room temperature remain substantial challenges to practical spintronics. Here we report conduction electron spin–lattice and spin–spin relaxation times of 175 ns at 300 K in 37±7 nm carbon spheres, which is remarkably long for any conducting solid-state material of comparable size. Following the observation of spin polarization by electron spin resonance, we control the quantum state of the electron spin by applying short bursts of an oscillating magnetic field and observe coherent oscillations of the spin state. These results demonstrate the feasibility of operating electron spins in conducting carbon nanospheres as quantum bits at room temperature.
Molecular signatures of neural connectivity in the olfactory cortex
Authors: Diodato Assunta , Ruinart de Brimont Marion , Yim Yeong Shin , Derian Nicolas , Perrin Sandrine , Pouch Juliette , Klatzmann David , Garel Sonia , Choi Gloria B , Fleischmann Alexander
Published: July 2016

The ability to target subclasses of neurons with defined connectivity is crucial for uncovering neural circuit functions. The olfactory (piriform) cortex is thought to generate odour percepts and memories, and odour information encoded in piriform is routed to target brain areas involved in multimodal sensory integration, cognition and motor control. However, it remains unknown if piriform outputs are spatially organized, and if distinct output channels are delineated by different gene expression patterns. Here we identify genes selectively expressed in different layers of the piriform cortex. Neural tracing experiments reveal that these layer-specific piriform genes mark different subclasses of neurons, which project to distinct target areas. Interestingly, these molecular signatures of connectivity are maintained in reeler mutant mice, in which neural positioning is scrambled. These results reveal that a predictive link between a neuron’s molecular identity and connectivity in this cortical circuit is determined independent of its spatial position.
Plasma phospholipids and fatty acid composition differ between liver biopsy-proven nonalcoholic fatty liver disease and healthy subjects
Authors: Ma D W L , Arendt B M , Hillyer L M , Fung S K , McGilvray I , Guindi M , Allard J P
Published: July 2016

Background:

There is growing evidence that nonalcoholic fatty liver disease (NAFLD) is associated with perturbations in liver lipid metabolism. Liver phospholipid and fatty acid composition have been shown to be altered in NAFLD. However, detailed profiles of circulating lipids in the pathogenesis of NAFLD are lacking.

Objective:

Therefore, the objective of the present study was to examine circulating lipids and potential mechanisms related to hepatic gene expression between liver biopsy-proven simple steatosis (SS), nonalcoholic steatohepatitis (NASH) and healthy subjects.

Subjects:

Plasma phospholipid and fatty acid composition were determined in 31 healthy living liver donors as healthy controls (HC), 26 patients with simple hepatic steatosis (SS) and 20 with progressive NASH. Hepatic gene expression was analyzed by Illumina microarray in a subset of 22 HC, 16 SS and 14 NASH.

Results:

Concentrations of phosphatidylethanolamine (PE) increased relative to disease progression, HC<SS<NASH (170<210<250 μg ml−1), and was significantly different (P<0.05) between HC and NASH. Circulating phosphatidylserine (PS) and phosphatidylinositol were higher in SS and NASH compared with HC (P<0.05), but there was no difference between SS and NASH. Fatty acid composition of phospholipids was also remodeled. In particular, docosahexaenoic and arachidonic acid were higher (P<0.05) in SS and NASH relative to HC in PS. Differentially expressed hepatic genes included ETNK1 and PLSCR1 that are involved in PE synthesis and PS transport, respectively.

Conclusions:

The present study demonstrates that there is a disruption in phospholipid metabolism that is present in SS, but more pronounced in NASH. Intervention studies targeted at lipid metabolism could benefit SS and NASH.
Modular, Antibody-free Time-Resolved LRET Kinase Assay Enabled by Quantum Dots and Tb3+-sensitizing Peptides
Authors: Cui Wei , Parker Laurie L.
Published: July 2016

Fluorescent drug screening assays are essential for tyrosine kinase inhibitor discovery. Here we demonstrate a flexible, antibody-free TR-LRET kinase assay strategy that is enabled by the combination of streptavidin-coated quantum dot (QD) acceptors and biotinylated, Tb3+ sensitizing peptide donors. By exploiting the spectral features of Tb3+ and QD, and the high binding affinity of the streptavidin-biotin interaction, we achieved multiplexed detection of kinase activity in a modular fashion without requiring additional covalent labeling of each peptide substrate. This strategy is compatible with high-throughput screening, and should be adaptable to the rapidly changing workflows and targets involved in kinase inhibitor discovery.
Template Free and Binderless NiO Nanowire Foam for Li-ion Battery Anodes with Long Cycle Life and Ultrahigh Rate Capability
Authors: Liu Chueh , Li Changling , Ahmed Kazi , Mutlu Zafer , Ozkan Cengiz S. , Ozkan Mihrimah
Published: July 2016

Herein, NiO-decorated Ni nanowires with diameters ca. 30–150 nm derived from Ni wire backbone (ca. 2 μm in diameter) is directly synthesized on commercially available Ni foam as a renovated anode for Li-ion batteries. Excellent stability with capacity 680 mAh g−1 at 0.5C (1C = 718 mA g−1) is achieved after 1000 cycles. Superior rate capability is exhibited by cycling at extremely high current rates, such as 20C and 50C with capacities ca. 164 and 75 mAh g−1, respectively. The capacity can be recovered back to ca. 430 mAh g−1 in 2 cycles when lowered to 0.2C and stably cycled for 430 times with capacity 460 mAh g−1. The NiO nanowire foam anode possesses low equivalent series resistance ca. 3.5 Ω, resulting in superior power performance and low resistive losses. The NiO nanowire foam can be manufactured with bio-friendly chemicals and low temperature processes without any templates, binders and conductive additives, which possesses the potential transferring from lab scale to industrial production.
Electric control of superconducting transition through a spin-orbit coupled interface
Authors: Ouassou Jabir Ali , Di Bernardo Angelo , Robinson Jason W. A. , Linder Jacob
Published: July 2016

We demonstrate theoretically all-electric control of the superconducting transition temperature using a device comprised of a conventional superconductor, a ferromagnetic insulator and semiconducting layers with intrinsic spin-orbit coupling. By using analytical calculations and numerical simulations, we show that the transition temperature of such a device can be controlled by electric gating which alters the ratio of Rashba to Dresselhaus spin-orbit coupling. The results offer a new pathway to control superconductivity in spintronic devices.
Topographical functional connectivity patterns exist in the congenitally, prelingually deaf
Authors: Striem-Amit Ella , Almeida Jorge , Belledonne Mario , Chen Quanjing , Fang Yuxing , Han Zaizhu , Caramazza Alfonso , Bi Yanchao
Published: July 2016

Congenital deafness causes large changes in the auditory cortex structure and function, such that without early childhood cochlear-implant, profoundly deaf children do not develop intact, high-level, auditory functions. But how is auditory cortex organization affected by congenital, prelingual and long standing deafness? Does the large-scale topographical organization of the auditory cortex develop in people deaf from birth? And is it retained despite cross-modal plasticity? We identified, using fMRI, topographic tonotopy-based functional connectivity (FC) structure in humans in the core auditory cortex, its extending tonotopic gradients in the belt and even beyond that. These regions show similar FC structure in the congenitally deaf throughout the auditory cortex, including in the language areas. The topographic FC pattern can be identified reliably in the vast majority of the deaf, at the single subject level, despite the absence of hearing-aid use and poor oral language skills. These findings suggest that large-scale tonotopic-based FC does not require sensory experience to develop and is retained despite life-long auditory deprivation and cross-modal plasticity. Furthermore, as the topographic FC is retained to varying degrees among the deaf subjects, it may serve to predict the potential for auditory rehabilitation using cochlear implants in individual subjects.
Distributed lag effects and vulnerable groups of floods on bacillary dysentery in Huaihua, China
Authors: Liu Zhi-Dong , Li Jing , Zhang Ying , Ding Guo-Yong , Xu Xin , Gao Lu , Liu Xue-Na , Liu Qi-Yong , Jiang Bao-Fa
Published: July 2016

Understanding the potential links between floods and bacillary dysentery in China is important to develop appropriate intervention programs after floods. This study aimed to explore the distributed lag effects of floods on bacillary dysentery and to identify the vulnerable groups in Huaihua, China. Weekly number of bacillary dysentery cases from 2005–2011 were obtained during flood season. Flood data and meteorological data over the same period were obtained from the China Meteorological Data Sharing Service System. To examine the distributed lag effects, a generalized linear mixed model combined with a distributed lag non-linear model were developed to assess the relationship between floods and bacillary dysentery. A total of 3,709 cases of bacillary dysentery were notified over the study period. The effects of floods on bacillary dysentery continued for approximately 3 weeks with a cumulative risk ratio equal to 1.52 (95% CI: 1.08–2.12). The risks of bacillary dysentery were higher in females, farmers and people aged 15–64 years old. This study suggests floods have increased the risk of bacillary dysentery with 3 weeks’ effects, especially for the vulnerable groups identified. Public health programs should be taken to prevent and control a potential risk of bacillary dysentery after floods.
Enhanced performance of lipase via microcapsulation and its application in biodiesel preparation
Authors: Su Feng , Li Guanlin , Fan Yanli , Yan Yunjun
Published: July 2016

In the present study, a surface-active enzyme, lipase was immobilized in polyethyleneimine (PEI) microcapsules and then modified with oxidized multiwall carbon nanotubes (MWCNTs). The resulting lipase microcapsules exhibited higher activity and stability, since the activity of microcapsules was 21.9 folds than that of the free counterpart. Numerous interfaces which were created in polycondensation enhanced the performance of lipases. Illustrated by confocal laser scanning microscope (CLSM), it was found that microcapsules, whose barrier properties against molecules with diameter >4.6 nm, were with a semipermeable and porous membrane structure. The lipases preferred to locate in the wall of the microcapsules. The oxidized multiwall carbon nanotubes (MWCNTs) were further added to modify microcapsules, resulting in even higher activity. The nanocomposites were examined by scanning electron microscope (SEM) and zeta-potential analyzer. The results indicated the superior catalytic performances were attributed to the augmented interface and decreased positive charge. Finally, the MWCNTs modified microcapsules were utilized in producing biodiesel with a 97.15% yield and retained nearly 90% yield after running 10 cycles. This approach of microcapsulation will be highly beneficial for preparing various bio-active microcapsules with excellent catalytic performance.
Strontium mineralization of shark vertebrae
Authors: Raoult Vincent , Peddemors Victor M. , Zahra David , Howell Nicholas , Howard Daryl L. , de Jonge Martin D. , Williamson Jane E.
Published: July 2016

Determining the age of sharks using vertebral banding is a vital component of management, but the causes of banding are not fully understood. Traditional shark ageing is based on fish otolith ageing methods where growth bands are assumed to result from varied seasonal calcification rates. Here we investigate these assumptions by mapping elemental distribution within the growth bands of vertebrae from six species of sharks representing four different taxonomic orders using scanning x-ray fluorescence microscopy. Traditional visual growth bands, determined with light microscopy, were more closely correlated to strontium than calcium in all species tested. Elemental distributions suggest that vertebral strontium bands may be related to environmental variations in salinity. These results highlight the requirement for a better understanding of shark movements, and their influence on vertebral development, if confidence in age estimates is to be improved. Analysis of shark vertebrae using similar strontium-focused elemental techniques, once validated for a given species, may allow more successful estimations of age on individuals with few or no visible vertebral bands.
Correction: Corrigendum: Difference in Visual Social Predispositions Between Newborns at Low- and High-risk for Autism
Authors: Di Giorgio Elisa , Frasnelli Elisa , Rosa Salva Orsola , Scattoni Maria Luisa , Puopolo Maria , Tosoni Daniela ,   NIDA-Network, Apicella Fabio , Gagliano Antonella , Guzzetta Andrea , Molteni Massimo , Persico Antonio , Pioggia Giovanni , Valeri Giovanni , Vicari Stefano , Simion Francesca , Vallortigara Giorgio
Published: July 2016

Scientific Reports 6: Article number: 26395; published online: 20 May 2016; updated: 18 July 2016 The original version of this Article contained an error in the spelling of the author Maria Luisa Scattoni which was incorrectly given as Scattoni Maria Luisa. These errors have now been corrected in the PDF and HTML versions of the Article.
EDN1 Gene Variant is Associated with Neonatal Persistent Pulmonary Hypertension
Authors: Mei Mei , Cheng Guoqiang , Sun Bijun , Yang Lin , Wang Huijun , Sun Jinqiao , Zhou Wenhao
Published: July 2016

Recent studies have suggested associations between certain genetic variants and susceptibility to persistent pulmonary hypertension of the newborn (PPHN). The aim of the study was to evaluate the association of EDN1, NOS3, ACE and VEGFA genes with PPHN. Neonates with respiratory distress were enrolled in the study, whose gestational age ≥34 weeks, age ≤3 days. They were divided into PPHN and non-PPHN group. The EDN1, NOS3, ACE and VEGFA genes were detected by next-generation sequencing and the results were validated by Sanger sequencing. Serum endothelin-1 (ET-1) levels were quantified by ELISA. A total of 112 neonates were enrolled (n = 55 in PPHN group; n = 57 in non-PPHN group). There is a significantly difference in the genotype distribution of EDN1 rs2070699 between the PPHN and non-PPHN group (P = 0). A higher frequency of the rs2070699 T allele was observed in the PPHN group (54.5% vs 27.2%; OR = 3.89; 95%CI 1.96–7.72). The rs2070699 T allele was associated with higher ET-1 levels (3.333 ± 2.517 pg/mL vs 1.223 ± 0.856 pg/mL; P = 0.002) and a longer ventilation period (5.8 ± 2.6 days vs 3.6 ± 3.3 days; P = 0). The results suggest there is an association between EDN1 and PPHN. The presence of the rs2070699 T allele increased the risk of PPHN in neonates with respiratory distress.
Predictability of Precipitation Over the Conterminous U.S. Based on the CMIP5 Multi-Model Ensemble
Authors: Jiang Mingkai , Felzer Benjamin S. , Sahagian Dork
Published: July 2016

Characterizing precipitation seasonality and variability in the face of future uncertainty is important for a well-informed climate change adaptation strategy. Using the Colwell index of predictability and monthly normalized precipitation data from the Coupled Model Intercomparison Project Phase 5 (CMIP5) multi-model ensembles, this study identifies spatial hotspots of changes in precipitation predictability in the United States under various climate scenarios. Over the historic period (1950–2005), the recurrent pattern of precipitation is highly predictable in the East and along the coastal Northwest, and is less so in the arid Southwest. Comparing the future (2040–2095) to the historic period, larger changes in precipitation predictability are observed under Representative Concentration Pathways (RCP) 8.5 than those under RCP 4.5. Finally, there are region-specific hotspots of future changes in precipitation predictability, and these hotspots often coincide with regions of little projected change in total precipitation, with exceptions along the wetter East and parts of the drier central West. Therefore, decision-makers are advised to not rely on future total precipitation as an indicator of water resources. Changes in precipitation predictability and the subsequent changes on seasonality and variability are equally, if not more, important factors to be included in future regional environmental assessment.
Life-history trait plasticity and its relationships with plant adaptation and insect fitness: a case study on the aphid Sitobion avenae
Authors: Dai Peng , Shi Xiaoqin , Liu Deguang , Ge Zhaohong , Wang Da , Dai Xinjia , Yi Zhihao , Meng Xiuxiang
Published: July 2016

Phenotypic plasticity has recently been considered a powerful means of adaptation, but its relationships with corresponding life-history characters and plant specialization levels of insects have been controversial. To address the issues, Sitobion avenae clones from three plants in two areas were compared. Varying amounts of life-history trait plasticity were found among S. avenae clones on barley, oat and wheat. In most cases, developmental durations and their corresponding plasticities were found to be independent, and fecundities and their plasticities were correlated characters instead. The developmental time of first instar nymphs for oat and wheat clones, but not for barley clones, was found to be independent from its plasticity, showing environment-specific effects. All correlations between environments were found to be positive, which could contribute to low plasticity in S. avenae. Negative correlations between trait plasticities and fitness of test clones suggest that lower plasticity could have higher adaptive value. Correlations between plasticity and specialization indices were identified for all clones, suggesting that plasticity might evolve as a by-product of adaptation to certain environments. The divergence patterns of life-history plasticities in S. avenae, as well as the relationships among plasticity, specialization and fitness, could have significant implications for evolutionary ecology of this aphid.
Systematic analysis of an evolved Thermobifida fusca muC producing malic acid on organic and inorganic nitrogen sources
Authors: Deng Yu , Lin Jia , Mao Yin , Zhang Xiaojuan
Published: July 2016

Thermobifida fusca is a thermophilic actinobacterium. T. fusca muC obtained by adaptive evolution preferred yeast extract to ammonium sulfate for accumulating malic acid and ammonium sulfate for cell growth. We did transcriptome analysis of T. fusca muC on Avicel and cellobiose with addition of ammonium sulfate or yeast extract, respectively by RNAseq. The transcriptional results indicate that ammonium sulfate induced the transcriptions of the genes related to carbohydrate metabolisms significantly more than yeast extract. Importantly, Tfu_2487, encoding histidine-containing protein (HPr), didn’t transcribe on yeast extract at all, while it transcribed highly on ammonium sulfate. In order to understand the impact of HPr on malate production and cell growth of the muC strain, we deleted Tfu_2487 to get a mutant strain: muCΔ2487, which had 1.33 mole/mole-glucose equivalent malate yield, much higher than that on yeast extract. We then developed an E. coli-T. fusca shuttle plasmid for over-expressing HPr in muCΔ2487, a strain without HPr background, forming the muCΔ2487S strain. The muCΔ2487S strain had a much lower malate yield but faster cell growth than the muC strain. The results of both mutant strains confirmed that HPr was the key regulatory protein for T. fusca’s metabolisms on nitrogen sources.
Electrothermal supercharging of proteins in native MS: effects of protein isoelectric point, buffer, and nanoESI-emitter tip size
Authors: Mortensen Daniel N. , Williams Evan R.
Published: July 2016

The extent of charging resulting from electrothermal supercharging increases with decreasing tip size for positively charged proteins.
Electrochemical detection of PCR amplicons of Escherichia coli genome based on DNA nanostructural probes and polyHRP enzyme
Authors: Wen Yanli , Wang LeLe , Xu Li , Li Lanying , Ren Suzhen , Cao Chengming , Jia Nengqin , Aldalbahi Ali , Song Shiping , Shi Jiye , Xia Jiaoyun , Liu Gang , Zuo Xiaolei
Published: July 2016

Fast, portable and sensitive analysis ofE. coliis becoming an important challenge in many critical fields (e.g., food safety, environmental monitoring and clinical diagnosis).
Catalytic enantioselective epoxidation of nitroalkenes
Authors: Vidal-Albalat A. , Świderek K. , Izquierdo J. , Rodríguez S. , Moliner V. , González F. V.
Published: July 2016

Nitroepoxides are potentially exploitable as synthons with vicinal electrophilic centers.
Extreme high temperature redox kinetics in ceria: exploration of the transition from gas-phase to material-kinetic limitations
Authors: Ji Ho-Il , Davenport Timothy C. , Gopal Chirranjeevi Balaji , Haile Sossina M.
Published: July 2016

Overcoming influences of oxygen release or uptake from the solid phase in relaxation experiments requires large gas flow rates, as dictated by the thermodynamic properties of the solid.
From adsorption to condensation: the role of adsorbed molecular clusters
Authors: Yaghoubian Sima , Zandavi Seyed Hadi , Ward C. A.
Published: July 2016

Phase transition from an adsorbed vapour to an adsorbed liquid at a subcooling temperature of 2.7 ± 0.4 K.
Alkylamine-functionalized hexagonal boron nitride nanoplatelets as a novel material for the reduction of friction and wear
Authors: Kumari Sangita , Sharma Om P , Khatri Om P
Published: July 2016

Alkylamine-functionalized hexagonal boron nitride nanoplatelets exhibiting long-term dispersion stability were demonstrated as novel additives for the reduction of friction and wear.
Protein cages and synthetic polymers: a fruitful symbiosis for drug delivery applications, bionanotechnology and materials science
Authors: Rother Martin , Nussbaumer Martin G. , Renggli Kasper , Bruns Nico
Published: July 2016

Protein cages have become essential tools in bionanotechnology due to their well-defined, monodisperse, capsule-like structure. Combining them with synthetic polymers greatly expands their application, giving rise to novel nanomaterials fore.g.drug-delivery, sensing, electronic devices and for uses as nanoreactors.
New insights into how Pd nanoparticles influence the photocatalytic oxidation and reduction ability of g-C3N4nanosheets
Authors: Ni Zilin , Dong Fan , Huang Hongwei , Zhang Yuxin
Published: July 2016

The Pd nanoparticles promoted photocatalytic oxidation and inhibited reduction ability of g-C3N4due to their different roles in different photocatalysis reactions.
All-or-none switching of photon upconversion in self-assembled organogel systems
Authors: Duan Pengfei , Asthana Deepak , Nakashima Takuya , Kawai Tsuyoshi , Yanai Nobuhiro , Kimizuka Nobuo
Published: July 2016

Aggregation-induced photon upconversion (iPUC) based on a triplet–triplet annihilation (TTA) process is successfully developed via controlled self-assembly of donor–acceptor pairs in organogel nanoassemblies. Although segregation of donor from acceptor assemblies has been an outstanding problem in TTA-based UC and iPUC, we resolved this issue by modifying both the triplet donor and aggregation induced emission (AIE)-type acceptor with glutamate-based self-assembling moieties. These donors and acceptors co-assemble to form organogels without segregation. Interestingly, these donor–acceptor binary gels show upconversion at room temperature but the upconversion phenomena were lost upon dissolution of the gels on heating. The observed changes in TTA-UC emission were thermally reversible, reflecting the controlled assembly/disassembly of the binary molecular systems. The observed on/off ratio of UC emission was much higher than that of the aggregation-induced fluorescence of the acceptor, which highlights the important role of iPUC, i.e., multi-exciton TTA for photoluminescence switching. This work bridges iPUC and supramolecular chemistry and provides a new strategy for designing stimuli-responsive upconversion systems.
Closing Pandora's box: chemical products should be designed to preserve efficacy of function while reducing toxicity
Authors: Jackson W. Roy , Campi Eva M. , Hearn Milton T. W.
Published: July 2016

The application of the Twelve Principles in the design of chemicals with reduced toxicity.
Template-assisted extrusion of biopolymer nanofibers under physiological conditions
Authors: Raoufi Mohammad , Aslankoohi Neda , Mollenhauer Christine , Boehm Heike , Spatz Joachim P. , Brüggemann Dorothea
Published: July 2016

Biomedical applications ranging from tissue engineering to drug delivery systems require versatile biomaterials based on the scalable and tunable production of biopolymer nanofibers under physiological conditions.
Virtual membrane for filtration of particles using surface acoustic waves (SAW)
Authors: Fakhfouri Armaghan , Devendran Citsabehsan , Collins David J. , Ai Ye , Neild Adrian
Published: July 2016

Surface acoustic wave (SAW) based particle manipulation is contactless, versatile, non-invasive and biocompatible making it useful for biological studies and diagnostic technologies.
Nickel catalyzed α-arylation of ketones with aryltrimethylammonium triflates
Authors: Li Jing , Wang Zhong-Xia
Published: July 2016

C(sp3)–C(sp2) coupling of aromatic ketones with a variety of aryltrimethylammonium triflates was performed in the presence of Ni(COD)2, IPr·HCl, and LiOBut to yield α-arylated ketones in reasonable to excellent yields.
A composition-controlled cross-linking resin network through rapid visible-light photo-copolymerization
Authors: Yang Yin , Urbas Aaron , Gonzalez-Bonet Andres , Sheridan Richard J. , Seppala Jonathan E. , Beers Kathryn L. , Sun Jirun
Published: July 2016

This work introduces a cross-linked resin network with controlled chemical composition, a clinically practical procedure to make it in situ, and appropriate analytical tools for chemical structure and kinetic studies.
Side-chain poly(phosphoramidate)s via acyclic diene metathesis polycondensation
Authors: Cankaya Alper , Steinmann Mark , Bülbül Yagmur , Lieberwirth Ingo , Wurm Frederik R.
Published: July 2016

Side-chain poly(phosphoramidate)s (PPAs) have been prepared by ADMET polycondensation and compared to structural analogues of poly(phosphoester)s. Thermal properties, stability, and crystallization behavior were analyzed. This is the first example for PPAs prepared by ADMET.
Encapsulation of epoxy and amine curing agent in PAN nanofibers by coaxial electrospinning for self-healing purposes
Authors: Neisiany Rasoul Esmaeely , Khorasani Saied Nouri , Kong Yoong Lee Jeremy , Ramakrishna Seeram
Published: July 2016

Encapsulation of epoxy resin and amine based curing agent in core–shell nanofibres using coaxial electrospinning.
Low viscosity-PLGA scaffolds by compressed CO2foaming for growth factor delivery
Authors: Diaz-Gomez L. , Yang F. , Jansen J. A. , Concheiro A. , Alvarez-Lorenzo C. , García-González C. A.
Published: July 2016

Foaming technology using supercritical and compressed fluids has emerged as a promising solution in regenerative medicine for manufacturing porous polymeric scaffolds.
Study of structural and conduction properties of Co3O4-doped corundum-type Mg4Ta2O9ceramics
Authors: Mohanty Parthasarathi
Published: July 2016

The effects of structural distortion on charge transport, crystal defects and relaxor response are studied for corundum-type (Mg1−xCox)4Ta2O9(x= 0–0.5) ceramics.
Development of novel hydrogels based on Salecan and poly(N-isopropylacrylamide-co-methacrylic acid) for controlled doxorubicin release
Authors: Qi Xiaoliang , Wei Wei , Li Junjian , Zuo Gancheng , Hu Xinyu , Zhang Jianfa , Dong Wei
Published: July 2016

We designed a novel semi-interpenetrating polymer network hydrogel for the controlled delivery of doxorubicin.
Carbon nanotube decorated NaTi2(PO4)3/C nanocomposite for a high-rate and low-temperature sodium-ion battery anode
Authors: Wang Lei , Wang Bo , Liu Guijing , Liu Tiefeng , Gao Tiantian , Wang Dianlong
Published: July 2016

NTP/C–CNTs with CNT decorated NTP/C nanoparticles enhance the electrolyte infiltration and provide fast transport pathways for electrons to achieve high-rate capability and low-temperature performance.
A DFT study of five-membered nitrogen-containing fused heterocycles for insensitive highly energetic materials
Authors: Zeng Qun , Qu Yanyang , Li Jinshan , Huang Hui
Published: July 2016

A suitable combination of aromatic rings, hydrogen bonds and layered crystal packing can be applied to obtain new compounds with both power and safety aspects.
Structural and physico-chemical characterization of a dirhamnolipid biosurfactant purified from Pseudomonas aeruginosa: application of crude biosurfactant in enhanced oil recovery
Authors: Gogoi Debananda , Bhagowati Pabitra , Gogoi Pronob , Bordoloi Naba K. , Rafay Abu , Dolui Swapan K. , Mukherjee Ashis K.
Published: July 2016

The present study describes the structural characterization and biotechnological application of a dirhamnolipid biosurfactant produced byPseudomonas aeruginosastrain NBTU-01 isolated from a petroleum oil-contaminated soil sample.
Negative imaginary parts of complex permeability and microwave absorption performance of core double-shelled FeCo/C/Fe2.5Cr0.5Se4 nanocomposites
Authors: Li D. , Feng Y. , Pan D. S. , Jiang L. W. , Dai Z. M. , Li S. J. , Wang Y. , He J. , Liu W. , Zhang Z. D.
Published: July 2016

Cactus-shaped core double-shelled FeCo/C/Fe2.5Cr0.5Se4 nanostructures with a spiky surface were prepared by combining an arc-discharge process with a high-temperature solution chemical method.
Enhanced cycling stability and rate capability of Bi2O3-coated Li1.2Mn0.54Ni0.13Co0.13O2 cathode materials for lithium-ion batteries
Authors: Zhou Lin , Wu Huali , Tian Mijie , Zheng Qiaoji , Xu Chenggang , Lin Dunmin
Published: July 2016

The LMNC-BO electrode presents an enhanced cycle performance, better rate capability and structural stability than bare LMNC.
The impact of MOF feasibility to improve the desalination performance and antifouling properties of FO membranes
Authors: Zirehpour Alireza , Rahimpour Ahmad , Khoshhal Saeed , Firouzjaei Mostafa Dadashi , Ghoreyshi Ali Asghar
Published: July 2016

In this study, a hydrophilic metal–organic framework (MOF) was applied to improve the performance of a cellulosic membrane for forward osmosis (FO) desalination application.
Controllable wetting state high adhesion hydrophobic surface
Authors: Wang Zeqing , Cong Yuehua , Zhang Baoyan
Published: July 2016

High adhesion hydrophobic surfaces with high apparent contact angles were achieved by a convenient approach.
Mesoporous Al-incorporated silica-pillared clay interlayer materials for catalytic hydroxyalkylation of phenol to bisphenol F
Authors: Wu Xianzhang , Xia Xinnian , Chen You , Lu Yanbing
Published: July 2016

Mesoporous Al-incorporated silica-pillared clay interlayer materials for catalytic hydroxyalkylation of phenol to bisphenol F.
Enzymatic synthesis of ibuprofen monoglycerides catalyzed by free Candida antarctica lipase B in a toluene–glycerol biphasic medium
Authors: Ravelo Marianela , Esteban Jesús , Ladero Miguel , García-Ochoa Félix
Published: July 2016

Reactive distillation in the presence of toluene permits the intensification of ibuprofen monoglyceride synthesis by means of aCandida antarcticaindustrial solution, attaining total conversion.
Catalytic oxidative C–C bond cleavage route of levulinic acid and methyl levulinate
Authors: Xia Fei , Du Zhongtian , Liu Junxia , Ma Yangyang , Xu Jie
Published: July 2016

The difference in the catalytic oxidative cleavage route between levulinic acid and methyl levulinate was intensively investigated.
Site-specific orthometallation via C–H bond activation and syntheses of ruthenium(iii) organometallics: studies on nitric oxide (NO) reactivity and photorelease of coordinated NO
Authors: Kumar Rajan , Kumar Sushil , Bala Manju , Ratnam Anand , Singh U. P. , Ghosh Kaushik
Published: July 2016

σ-Aryl ruthenium(iii) complexes were synthesized by C–H bond activation and organometallic nitrosyl complexes were synthesized and characterized by spectroscopy and crystal structure. Coordinated NO molecule was found to be photolabile.
A concerted two-prong approach to the in situ allosteric regulation of bifunctional catalysis
Authors: McGuirk C. Michael , Mendez-Arroyo Jose , d'Aquino Andrea I. , Stern Charlotte L. , Liu Yuan , Mirkin Chad A.
Published: July 2016

The allosteric regulation of bifunctional catalysis is achieved through the simultaneous use of reversible acid–base and structurally addressable coordination chemistry.
Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization
Authors: Baudouin D. , van Kalkeren H. A. , Bornet A. , Vuichoud B. , Veyre L. , Cavaillès M. , Schwarzwälder M. , Liao W.-C. , Gajan D. , Bodenhausen G. , Emsley L. , Lesage A. , Jannin S. , Copéret C. , Thieuleux C.
Published: July 2016

Porous network architecture of hybrid silicas containing TEMPO radicals along their pores is key for increased hyperpolarization performances.
Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cells in vitro and in vivo by varying counter anions
Authors: Huang Yanyan , Zhang Guanxin , Hu Fang , Jin Yulong , Zhao Rui , Zhang Deqing
Published: July 2016

The cell selectivity, subcellular localization and cytotoxicity can be tuned by the counter anions of nanoparticles assembled from pyridinium-substituted tetraphenylethylene.
White multi-layered polymer light emitting diode through matrix assisted pulsed laser evaporation
Authors: Mariano F. , Caricato A. P. , Accorsi G. , Leo C. , Cesaria M. , Carallo S. , Genco A. , Simeone D. , Tunno T. , Martino M. , Gigli G. , Mazzeo M.
Published: July 2016

UV-MAPLE deposition technique can be exploited to deposit a multi-layered polymeric stack and allows for the fabrication of a white organic light-emitting device.
Achievable rates of a state‐dependent relay channel with orthogonal components
Authors: Al‐qudah Zouhair
Published: July 2016

A relay channel, with orthogonal components, is considered in the case that the spectrum is shared by another user. Upper bounds on the achievable capacity is obtained when noisy observations of the interference signal is non‐causally available at the three nodes forming the relay channel. Then, a causal encoding technique is proposed such that the source and the relay can at first estimate the interference signal and then start transmission to the destination. In addition, rigorous numerical examples are studied to illustrate the benefit of having noisy observations of the interference signal at the three nodes forming the relay channel.
Pragmatic phase noise compensation for high‐order coded modulations
Authors: Martalò Marco , Ferrari Gianluigi , Asim Muhammad , Gambini Jonathan , Mazzucco Christian , Cannalire Giacomo , Bianchi Sergio , Raheli Riccardo
Published: July 2016

This study discusses synchronisation in phase noise‐impaired spectrally efficient communication systems employing high‐order modulations. In particular, an iterative receiver, where demodulation and decoding are separate from maximum a posteriori probability (MAP) synchronisation, is presented. The authors’ separate approach is tailored to the design of pragmatic iterative receiver schemes employing ‘off‐the‐shelf’ demodulation and decoding blocks. This allows full compatibility with already existing systems, which is attractive from the implementation viewpoint. The proposed MAP synchronisation algorithm also requires very limited knowledge of the phase noise process and achieves near coherent performance with moderate computational complexity. Although the approach is very general, the authors discuss its performance for low‐density parity‐check‐coded pilot symbol‐aided quadrature amplitude modulation schemes, demonstrating that a significantly lower computational complexity can be achieved with respect to benchmark joint receivers.
Porous core photonic crystal fibre for ultra‐low material loss in THz regime
Authors: Islam Md.Saiful , Rana Sohel , Islam Mohammad Rakibul , Faisal Mohammad , Rahman Hasan , Sultana Jakeya
Published: July 2016

An extremely low‐loss porous core circular photonic crystal fibre is presented for terahertz (THz) wave guidance. Much of attention is given to the geometries of the fibre to increase the fraction of power transmitted through core air holes. The finite‐element method has been used to compute the modal characteristics of the fibre. Simulation results exhibit an ultra‐low material loss of −0.05 cm−1 which is one‐fourth of the bulk material loss and almost half of the useful power goes through core air holes at a frequency f = 1 THz. Besides, single‐mode properties, confinement loss and dispersion of the fibre are rigorously discussed. The proposed fibre can be fabricated using capillary stacking or sol–gel technique and is useful for transmission applications in the THz frequency band.
Damping torque analysis of power systems with DFIGs for wind power generation
Authors: Du Wenjuan , Bi Jingtian , Lv Chen , Littler Tim
Published: July 2016

A grid‐connected double fed induction generator(DFIG) for wind power generation can affect power system small‐signal angular stability in two ways: by changing the system load flow condition and dynamically interacting with synchronous generators (SGs). This study presents the application of conventional method of damping torque analysis (DTA) to examine the effect of DFIG's dynamic interactions with SGs on the small‐signal angular stability. It shows that the effect is due to the dynamic variation of power exchange between the DFIG and power system and can be estimated approximately by the DTA. Consequently, if the DFIG is modelled as a constant power source when the effect of zero dynamic interactions is assumed, the impact of change of load flow brought about by the DFIG can be determined. Thus the total effect of DFIG can be estimated from the result of DTA added on that of constant power source model. Applications of the DTA method proposed in this study are discussed. An example of multi‐machine power systems with grid‐connected DFIGs is presented to demonstrate and validate the DTA method proposed and conclusions obtained in this study.
Basal Cell Adenoma of Retromolar Region from Minor Salivary Gland Origin in a 45-Year-Old Female: A Case Report
Authors: Krishnan Velavan , Shunmugavelu Karthik , Rose Jamila , Subramaniam Kumaravel
Published: July 2016

Basal cell adenoma is a rare benign salivary gland neoplasm. The most common location is in parotid region. Clinically, gradual growth and firm consistency are seen. They account for 1 to 3% among all salivary gland neoplasms. Prominent basaloid cells with cluster of isomorphic cells and interspersed trabeculae are present histopathologically. In this article, we present a rare case of basal cell adenoma of retromolar region from minor salivary gland origin.