bluuebunny/crossref_metadata_2025 huggingface dataset:
How different approaches to taking pictures influences participation in a photovoice project
Authors: Bendell Katherine , Sylvestre John
Published: June 2016

Photovoice involves participants using cameras to document their thoughts and experiences related to an important theme in their everyday lives. Photovoice places the critical data collection tool, a camera, in the control of the participants themselves. Thus, the knowledge that is generated from a photovoice project is likely to directly reflect the interests and concerns of the participants. This project offers a unique view of how participants’ varying approaches to photography influenced their experiences of participation as well as the photographs they took.
Paradoxical development of neovascular glaucoma following carotid angioplasty and stenting
Authors: Lee Kyung Mi , Kim Eui Jong , Heo Sung Hyuk , Jin Kyung Hyun
Published: June 2016

This report describes a very rare ocular complication of carotid intervention. A 74-year-old patient presented with left-sided weakness and was diagnosed with right cerebral border-zone infarctions caused by severe stenosis of the right proximal internal carotid artery. Staged carotid intervention (balloon angioplasty followed by stenting) was successfully performed. However, neovascular glaucoma developed following carotid angioplasty and stenting. We concluded that although carotid angioplasty and stenting improves vision in patients with ischemic oculopathy, it can rarely induce paradoxical visual deterioration such as development or aggravation of neovascular glaucoma.
“Do Not Remember the Former Things”
Authors: Rynkiewich Michael A.
Published: June 2016

There are times when God says “Remember,” and times where God says “Do not remember.” Discerning the times is a constant requirement in mission studies and practice. The times are changing, and so are the means of interpreting the times. Urbanization, globalization, migration, and diaspora have created a world that, in many ways, is unlike any we have seen before. In missiology, updating our methods of doing research offers the best chance to reshape our models and mottoes for mission.
Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor
Authors: Wijeyewickrema Lakshmi C. , Lameignere Emilie , Hor Lilian , Duncan Renee C. , Shiba Toshikazu , Travers Richard J. , Kapopara Piyushkumar R. , Lei Victor , Smith Stephanie A. , Kim Hugh , Morrissey James H. , Pike Robert N. , Conway Edward M.
Published: June 2016

Key Points

PolyP, like heparin, is a physiologic cofactor for the C1-INH:C1s interaction, and thus a key negative regulator of complement. Colocalization of polyP with C1-INH in activated platelets suggests that its cofactor function is physiologically relevant.
Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma
Authors: Doran Emma , Choy David F. , Shikotra Aarti , Butler Claire A. , O'Rourke Declan M. , Johnston James A. , Kissenpfennig Adrien , Bradding Peter , Arron Joseph R. , Heaney Liam G.
Published: June 2016

Severe asthma represents a major unmet clinical need. Eosinophilic inflammation persists in the airways of many patients with uncontrolled asthma, despite high-dose inhaled corticosteroid therapy. Suppressors of cytokine signalling (SOCS) are a family of molecules involved in the regulation of cytokine signallingviainhibition of the Janus kinase–signal transducers and activators of transcription pathway. We examined SOCS expression in the airways of asthma patients and investigated whether this is associated with persistent eosinophilia.

Healthy controls, mild/moderate asthmatics and severe asthmatics were studied. Whole genome expression profiling, quantitative PCR and immunohistochemical analysis were used to examine expression of SOCS1, SOCS2 and SOCS3 in bronchial biopsies. Bronchial epithelial cells were utilised to examine the role of SOCS1 in regulating interleukin (IL)-13 signallingin vitro.

SOCS1 gene expression was significantly lower in the airways of severe asthmatics compared with mild/moderate asthmatics, and was inversely associated with airway eosinophilia and other measures of T-helper type 2 (Th2) inflammation. Immunohistochemistry demonstrated SOCS1 was predominantly localised to the bronchial epithelium. SOCS1 overexpression inhibited IL-13-mediated chemokine ligand (CCL) 26 (eotaxin-3) mRNA expression in bronchial epithelial cells.

Severe asthma patients with persistent airway eosinophilia and Th2 inflammation have reduced airway epithelial SOCS1 expression. SOCS1 inhibits epithelial IL-13 signalling, supporting its key role in regulating Th2-driven eosinophilia in severe asthma.
Exposure to ultrafine particles and respiratory hospitalisations in five European cities
Authors: Samoli Evangelia , Andersen Zorana Jovanovic , Katsouyanni Klea , Hennig Frauke , Kuhlbusch Thomas A.J. , Bellander Tom , Cattani Giorgio , Cyrys Josef , Forastiere Francesco , Jacquemin Bénédicte , Kulmala Markku , Lanki Timo , Loft Steffen , Massling Andreas , Tobias Aurelio , Stafoggia Massimo
Published: June 2016

Epidemiological evidence on the associations between exposure to ultrafine particles (UFP), with aerodynamic electrical mobility diameters <100 nm, and health is limited. We gathered data on UFP from five European cities within 2001–2011 to investigate associations between short-term changes in concentrations and respiratory hospitalisations.

We applied city-specific Poisson regression models and combined city-specific estimates to obtain pooled estimates. We evaluated the sensitivity of our findings to co-pollutant adjustment and investigated effect modification patterns by period of the year, age at admission and specific diagnoses.

Our results for the whole time period do not support an association between UFP and respiratory hospitalisations, although we found suggestive associations among those 0–14 years old. We nevertheless report consistent adverse effect estimates during the warm period of the year, statistically significant after lag 2 when an increase by 10 000 particles per cm3was associated with a 4.27% (95% CI 1.68–6.92%) increase in hospitalisations. These effect estimates were robust to particles' mass or gaseous pollutants adjustment.

Considering that our findings during the warm period may reflect better exposure assessment and that the main source of non-soluble UFP in urban areas is traffic, our results call for improved regulation of traffic emissions.
Consistency of biological networks inferred from microarray and sequencing data
Authors: Vinciotti Veronica , Wit Ernst C. , Jansen Rick , de Geus Eco J. C. N. , Penninx Brenda W. J. H. , Boomsma Dorret I. , ’t Hoen Peter A. C.
Published: June 2016

Background

Sparse Gaussian graphical models are popular for inferring biological networks, such as gene regulatory networks. In this paper, we investigate the consistency of these models across different data platforms, such as microarray and next generation sequencing, on the basis of a rich dataset containing samples that are profiled under both techniques as well as a large set of independent samples.

Results

Our analysis shows that individual node variances can have a remarkable effect on the connectivity of the resulting network. Their inconsistency across platforms and the fact that the variability level of a node may not be linked to its regulatory role mean that, failing to scale the data prior to the network analysis, leads to networks that are not reproducible across different platforms and that may be misleading. Moreover, we show how the reproducibility of networks across different platforms is significantly higher if networks are summarised in terms of enrichment amongst functional groups of interest, such as pathways, rather than at the level of individual edges.

Conclusions

Careful pre-processing of transcriptional data and summaries of networks beyond individual edges can improve the consistency of network inference across platforms. However, caution is needed at this stage in the (over)interpretation of gene regulatory networks inferred from biological data.
Intraflagellar transport is required for the maintenance of the trypanosome flagellum composition but not its length
Authors: Fort Cécile , Bonnefoy Serge , Kohl Linda , Bastin Philippe
Published: June 2016

Intraflagellar transport (IFT) is required for construction of most cilia and flagella. Here, we used electron microscopy, immunofluorescence and live video microscopy to show that IFT is absent or arrested in the mature flagellum of Trypanosoma brucei upon RNA interference (RNAi)-mediated knockdown of IFT88 and IFT140, respectively. Flagella assembled prior to RNAi did not shorten, showing that IFT is not essential for the maintenance of flagella length. Although the ultrastructure of the axoneme was not visibly affected, flagellar beating was strongly reduced and the distribution of several flagellar components was drastically modified. The R subunit of the protein kinase A was no longer concentrated in the flagellum but was largely found in the cell body whereas the kinesin 9B motor was accumulating at the distal tip of the flagellum. In contrast, the distal tip protein FLAM8 was dispersed along the flagellum. This reveals that IFT also functions in maintaining the distribution of some flagellar proteins after construction of the organelle is completed.
Phylogenetics, ancestral state reconstruction, and a new infrageneric classification of Scleria (Cyperaceae) based on three DNA markers
Authors: Bauters Kenneth , Asselman Pieter , Simpson David A. , Muasya A. Muthama , Goetghebeur Paul , Larridon Isabel
Published: June 2016

The genus Scleria (Cyperaceae), with ca. 250 species, is placed in the monotypic tribe Sclerieae. It has a primarily pantropical distribution. Previously, infrageneric classifications have been proposed but none has been based on molecular phylogenetic evidence and most studies have treated the genus from only one geographical region. In this study, DNA portions from 101 species of Scleria from across its distributional range and all infrageneric groups were extracted and amplified for three molecular markers: the coding chloroplast marker ndhF, the chloroplast intron rps16 and the nuclear ribosomal region ITS. Phylogenetic hypotheses were constructed using Bayesian inference and maximum likelihood approaches. Additionally, ancestral states of four morphological characters were reconstructed at important nodes using the program BayesTraits. A new infrageneric classification based on molecular evidence and supported by morphology is presented. Scleria is confirmed as monophyletic and sister to tribe Bisboeckelereae. A subdivision of Scleria into four subgenera (S. subg. Browniae, S. subg. Hypoporum, S. subg. Scleria, S. subg. Trachylomia) is supported by our results. In this paper, twelve major clades are recovered within Scleria subg. Scleria. Clear morphological diagnostic features match these clades. Ancestral state reconstruction indicates that androgynous spikelets, a zoniform hypogynium, a paniculate inflorescence with staminate and subandrogynous spikelets, and normal linear leaves are ancestral in Scleria. Androgynous spikelets are found in the three first‐branching subgenera, while in S. subg. Scleria an evolutionary shift towards subandrogynous and strictly unisexual spikelets is noted. Hypogynia are generally well developed with the exception of S. subg. Hypoporum, where the hypogynium is reduced or even lost. Inflorescences in Scleria vary from short, densely paniculate and pyramidal to subcapitate, only in S. subg. Hypoporum a glomerate‐spicate inflorescence is found. The pseudopremorse leaf habit arose only once within S. subg. Scleria. Scleria sect. Scleria shows a reversal to normal leaf tips.
Report of the Special Committee on By‐laws for the Nomenclature Section
Authors: Knapp Sandra , Turland Nicholas J. , Barkworth Mary E. , Barrie Fred R. , Fortunato Renée H. , Gandhi Kanchi , Gereau Roy E. , Greuter Werner , Herendeen Patrick S. , Landrum Leslie R. , Mabberley David J. , Marhold Karol , May Tom W. , Moore Gerry , Arce Lourdes Rico , Smith Gideon F. , Thiele Kevin , Zhang Li
Published: June 2016

The Special Committee on By‐laws for the Nomenclature Section was established at the XVIII International Botanical Congress (IBC) in Melbourne in 2011, with the mandate to formalize the procedures by which changes to the Code are considered and voted upon by the Nomenclature Section, and to report to the XIX IBC in Shenzhen in 2017. With the wider participation of the community in nomenclature in general, and to address some past contentious issues in particular, the need for a clearer set of rules for management of the Nomenclature Section had surfaced. In light of this, the Committee conducted extensive negotiations and discussions on a wide range of governance topics, which are here summarized in the Committee's report. We propose the adoption of a new and greatly expanded version of Division III of the Code. This report provides the supporting documentation for the proposal that is also published in this issue (Knapp & al. in Taxon 65: 661–664. 2016). It is necessary that the two documents be read alongside each other.
Familial classification of the Boraginales
Authors: Luebert Federico , Cecchi Lorenzo , Frohlich Michael W. , Gottschling Marc , Guilliams C. Matt , Hasenstab-Lehman Kristen E. , Hilger Hartmut H. , Miller James S. , Mittelbach Moritz , Nazaire Mare , Nepi Massimo , Nocentini Daniele , Ober Dietrich , Olmstead Richard G. , Selvi Federico , Simpson Michael G. , Sutorý Karel , Valdés Benito , Walden Genevieve K. , Weigend Maximilian
Published: June 2016

The Boraginales are now universally accepted as monophyletic and firmly placed in Lamiidae. However, a consensus about familial classification has remained elusive, with some advocating recognition of a single, widely variable family, and others proposing recognition of several distinct families. A consensus classification is proposed here, based on recent molecular phylogenetic studies, morphological characters, and taking nomenclatural stability into consideration. We suggest the recognition of eleven, morphologically well‐defined and clearly monophyletic families, namely the Boraginaceae s.str., Codonaceae, Coldeniaceae fam. nov., Cordiaceae, Ehretiaceae, Heliotropiaceae, Hoplestigmataceae, Hydrophyllaceae, Lennoaceae, Namaceae, and Wellstediaceae. Descriptions, synonomy, a taxonomic key, and a list of genera for these eleven families are provided, including the new family Coldeniaceae (monogeneric) and Namaceae (segregated from Hydrophyllaceae and comprising Nama, Eriodictyon, Turricula, and Wigandia), the latter necessitating a revised circumscription of a more morphologically coherent Hydrophyllaceae.
CORRELATION OF BEARING FRICTION ASSEMBLIES WITH ABRASIVE WEAR OF THEIR TRIBO-COUPLING
Authors: Шец Сергей , Shets Sergey , Сакало Владимир , Sakalo Vladimir , Суслов Анатолий , Suslov Anatoly
Published: June 2016

To ensure wear resistance of all tribo-couplings of a bearing assembly at the expense of the abrasive wear decrease it is necessary the solution of problems connected with the impermeability of their movable joints. In this case by the impermeability we imply a process of sealed “wall” formation which is able to separate reliably volumes with different environments at considerable changes of external factors of environment: temperature, dustiness, aggressiveness and others.

The contact of two hard surfaces of tribo-coupling of the “shaft-seal” type forms a system of cavities, capillaries of an arbitrary shape and contact patches. Under the action of pressure difference on separate capillaries arise leaks.

The depressurization of bearing friction assemblies (leak moment) results in the decrease of wear rate of tribo-coupling of “shaf-tseal” type, but a wear rate of other tribocouplings such as “ringsolid of rolling motion”, for frictionless bearings or “shaft-bushing” for friction bearings increases because of abrasive penetration into a contact area. The penetration of quartz particles (pollutions) through a sealing into a bearing assembly results in the increase of a constant of friction and initiation of abrasive wear in tribocouplings of “ringsolid of rolling motion” and “shaftbushing” types. The wear rate of “ringsolid of rolling motion” and “shaftbushing” couplings depends on the abrasive concentration in lubricant and a leak at the outlet from the bearing assembly. For the wear resistance increase in tribo-couplings of bearing assemblies it is necessary not only to increase the hardness of contact surfaces, ensure optimum roughness, select materials in tribo-couplings, but also to ensure the impermeability and lubricant keeping in a friction area.
MACHINERY LIFE INCREASE BY COMBINED STRENGTHENING
Authors: Соловьёв Д. , Solovev D. , Киричек Андрей , Kirichek Andrey , Тарасов Дмитрий , Tarasov Dmitriy
Published: June 2016

The reason of failure of many machine parts is contact fatigue. To increase contact-fatigue wear resistance it is necessary to create a surface layer possessing increased stress-strain properties which are formed by strengthening. The most effective methods of strengthening are those creating a surface layer with simultaneous high hardness and large reserve of plasticity. One of such methods is combined strengthening at which a surface to be strengthened is affected preliminarily by deformation shock waves forming a deep work-hardened layer and then its case hardening is carried out. As a result of this process a strengthened surface layer is formed which consists of hard uniformly strengthened carburized layer and a softer heterogeneously strengthened sublayer alternating hard and soft areas depending on streng-thening modes with shock waves. The operational researches of samples obtained by the offered combined strengthening have shown high efficiency of the method for life increase under conditions of contact cyclic loads which can increase considerably a range of machine parts to be strengthened.
INTENSITY DECREASE OF HORSESHOE WHIRLWINDS IN NOZZLE INSTRUMENTS OF TURBOMACHINES
Authors: Тулубенский Евгений , Tulubenskiy Evgeniy , Дроконов Алексей , Drokonov Aleksey , Осипов Александр , Osipov Aleksandr
Published: June 2016

In this research work there is offered an original method for nozzles designing allowing the structure improvement of the flow arriving in a distributor by means of manufacturing nozzle blades with a perforated input edge and a damping chamber located behind it or with cuts on the end areas of a blade. The analysis of aerodynamic properties of initial and up-dated variants of blades (perforation, making cuts and shears) is carried out with the use of the finite element method in the computation system of automated designing Autodesk Simulation CFD 2014 360. The analysis was carried out with the consideration of different grid models beginning with the simplest (from 500 000 finite elements) and ending with complex models with the closeness of finite elements near a blade profile (up to 2,000 000 finite elements). The research results show that the lowest level of velocities is observed in the variants with a perforated wall and longitudinal cuts. In such a way, these variants of embodiment allow decreasing considerably the intensity of horseshoe whirlwinds (up to 18-20%). A the analysis of pressure distribution in the output section in four variants of blade end area embodiment one can observe that in variants with a perforated wall and longitudinal cuts are seen the best values: in connection with lower pressure loss their effectiveness is on average about 0.2% higher, than the effectiveness of the initial model. The variants offered of the embodiment ensure also the decrease of vibro-acoustic activity of a stage.
CONDITION DEFINITION FOR APPLICATION OF UNIFORM BRAKE RIGGING WITH CYLINDERS (BCR) IN BRAKE SYSTEMS OF FRIGHT EIGHT-WHEEL CARS
Authors: Синицын Владимир , Sinitsyn Vladimir , Кобищанов Владимир , Kobishchanov Vladimir
Published: June 2016

The application of BCR (brake cylinders with the built-in regulator of rod output manufactured by Transpneumatics Co.) in a brake actuator in fright eightwheel cars with separate drives located in areas of car trucks is promising. Such a layout as is well known allows increasing fright car carrying capacity at the expense of an undercar area clearing. But the application of such systems for different types of cars is limited with design peculiarities of cars and a considerable scatter of reduction ratios.

The paper reports the consideration of a possibility for the location of a brake system with the BCR both in car truck areas, and on a car truck for a maximum possible quantity of car types. The limitations on the proportions of a lightweight and carrying capacity for fright cars operated in the RF in which the applica-tion of a uniform brake system is possible. The use of a cylinder in a brake system with the location on a car truck as a system least dependent on design peculiari-ties of cars is offered. The BCR-10-85 cylinder is cho-sen as one of the most possible variants of brake cy-linders.

A possibility of the application of a uniform rigging with the BCR-10-85 cylinder for cars with pressure control in cylinders with the aid of an auto-mated mode and application in a rigging of one or two holes for reduction ratio changes is defined. For cars having no possibility for pressure control in cylinders with the aid of an automated mode there is obtained a substantial quantity of reduction ratios depending on individual characteristics (lightweight and carrying capacity) of cars that does not allow using a uniform rigging.
ROD OSCILLATION INVESTIGATION OF ADAPTIVE TORSION SPRING FOR SPRING SUSPENSION OF SIX-WHEEL LOCOMOTIVE BOGIES
Authors: Радин Сергей , Radin Sergey , Сливинский Евгений , Slivinskiy Evgeniy , Митина Татьяна , Mitina Tatyana
Published: June 2016

In modern locomotive design to reduce a dynamic effect upon a track there are widely used jaw and lawless six-wheel bogies supplied with a spring suspension using laminated springs, cylindrical spiral springs of compression and pneumatic springs. A considerable drawback of all known designs of spring suspension for rolling-stock is that all of them apart from a pneumatic one have no possibility for self-regulation in an automatic mode of their rigid characteristics de-pending on external dynamic impacts of track unevenness upon the latter. There is developed in Bunin State University of Yelets a promising inventionleveled structure of an adaptive torsion spring suspension excluding such a drawback and a number of computa-tions was carried out for the substantiation its rational design values.
PROMISING DIRECTIONS TO INCREASE GRINDING EFFICIENCY IN MACHINE PARTS SURFACES
Authors: Кулинский Алексей Данилович , Kulinskiy Aleksey Danilovich , Гусакова Лиана , Gusakova Liana , Бутенко Виктор , Butenko Viktor
Published: June 2016

The problem of grinding process increase for machine parts surfaces can be solved by means of abrasive disks design updating, their composition and impregnation technologies. The structures of multiple grinding wheels containing rods in a basic abrasive mass including conducting elements are offered. Such disks allow increasing quality in surfaces machined of parts made of tough hardtomachine steel and alloys on the basis of nonferrous metals on indices of roughness, technological residual stresses and burns. High efficiency show multi-sector abrasive disks of different grain allowing the increase considerably the intensity of material removal at machining parts made of chro-mium-nickel steel and alloys. The effective composi-tions of abrasive masses are developed for tool manufacturing including the introduction in them highstrength ferritic iron, chromium diiodide and wood resin. Polishing tools made of abrasive mass have 1.5 –twice higher durability between stropping operations and ensure the decrease of burn areas quantity on ma-chined surfaces of parts 2-2.5 times. The promising direction of the efficiency increase in parts surface grinding is the impregnation of abrasive disks by an aqueous solution of chromium diiodide which possesses high anticeptic properties and at the iodine emission forms iron iodides with a low constant of friction. As a result of this the temperature drops in the grinding area by more than 30%.
ROTARY-HELICAL TECHNOLOGICAL SYSTEMS FOR PARTS MACHINING
Authors: Белокур Кирилл , Belokur Kirill , Серга Георгий , Serga Georgiy , Лебедев Валерий , Lebedev Valeriy , Яковлев Денис , Yakovlev Denis
Published: June 2016

The technical solutions for efficiency increase of technological systems for parts finishing and strengthening based on the use of screw containers are offered. The essence is revealed, design peculiarities and technological possibilities of a rotor-helical technological system with a vibrocontainer and an adjusting spring and a rotor-helical technological system with a rotating container are described. The results of experi-mental researches of granular material motion in a screw container with the use of three-factor experiment planning are shown. The assessment of the screw containers efficiency application reasoning from their design peculiarities is given.
TECHNOLOGY OPTIMIZATION FOR CENTRIFUGAL-CAST ROLL MANUFACTURING
Authors: Жижкина Наталья , Zhizhkina Natalya
Published: June 2016

This paper reports the sheet roll spun casting. It is shown that sheet rolls of required quality and with minimum production costs are manufactured through a method of spun casting on a machine with a vertical axis of a mould rotation. It is defined that at spun casting a more intensive foundry cooling occurs as a result of which a blank is characterized with a denser and more even structure of a working layer. It is revealed that the stability of such a process depends to a considerable degree upon a spin casting system functioning a significant property of which is a speed of rotation. In the paper there is analyzed a rotation speed influence upon a grain size, a quantitative ratio of structural constituents in a working layer composed of nickel-chromium cast iron and also upon the level of its properties. The analysis of the rotation speed influence of a casting mold upon a structure and a property level of a roll working surface was based on experimental investigations of foundries under industrial conditions. The microstructure (the size of primary grains, their composition) of products analyzed was estimated with the aid of a common metallographic procedure. On the basis of experiments carried out it is determined that even an insignificant increase (by 7%) of mould rotation speed during roll casting allows without expensive processing of liquid melt of a work-ing layer increasing its structure uniformity. As a result of this the level of its properties increases (hardness – by 3 units). Consequently, the increase of rolling tool efficiency is expected. The presented results of investigations are basic for works on servicing characteristics increase of spin-cast rolls.
AUTOMATION OF OPTIC INSPECTION CONTROL AT QUALITY MANAGEMENT OF PRINTED CIRCUIT ASSEMBLY SOLDERING
Authors: Аверченков Владимир , Averchenkov Vladimir , Самсоненко Александр , Samsonenko Aleksandr
Published: June 2016

The development of methods of designing and assembling electronic units on circuit boards with the use of surface assembling techniques (SAT) became one of the priority fields. The product optic control is the most common method of control carried out by specialized equipment, an automated optic inspection (AOI). On the basis of the fulfilled analysis of technical solutions on the organization of inspections of different manufacturers and according to the test results in practice of some variants there was offered a circuit including the following equipment layout: a set of chambers, a system of linear displacement, a controller, a computer and software.

The optical inspection software can be divided into the software of management and the software of control. The former serves for the computation of a control signal, the comparison of coordinates of equipment (with physical (F), imported (C) and in-spected (P)) interpretation of coordinates, interpolation and so on. The software of control contains modules: of data import from Gerberfile, the identification of board images obtained from the chamber, of the com-putation and comparison of identified components with a standard, of the analysis defects and the definition of a defect type, of database (DB) filling, of the interaction with a user.

The system described in comparison with foreign analogues has a smaller set of options, but solves a problem of control under conditions of enterprises manufacturing electronics of the second class (according to IPCA-610 Standard “Criteria for Electronic Assemblage Acceptance).
NEUROCOMPUTER MODELING OF CONTACT RIGIDITY
Authors: Тихомиров Петр , Tikhomirov Petr , Лемешева Елена , Lemesheva Elena , Булхов Николай , Bulkhov Nikolay , Атрощенко Анна , Atroshchenko Anna , Измеров Михаил , Izmerov Mikhail
Published: June 2016

Contact rigidity of a joint is one of the main criteria of operability of forest cars. It defines vibration activity and durability of the tightened bolted connections therefore its assessment will allow to predict behavior of technical systems. In work the technique of an assessment of contact rigidity by means of the nerocomputer modeling allowing to consider parameters of quality of a blanket is presented. Results of re-searches allowed to receive mathematical models for contact rigidity.

In the paper there is presented a procedure of contact rigidity estimate with the aid of neurocomputer modeling. A contact rigidity of a joint is one of the basic criteria of machine and mechanism capacity for work. It defines vibration activity and strength of tightened bolted connections therefore its estimate will allow forecasting the behavior of technical systems. Neurocomputer modeling is a promising method allowing taking into account quality parameters of a surface layer of machinery at the analysis of a deformed state.
METHOD ENSURING ACCESS TO INFORMATION TECHNOLOGICAL RESOURCES OF AUTOMATIC CONTROL SYSTEM BY WATER SUPPLY COMPANY
Authors: Рытов Михаил , Rytov Mikhail , Шпичак Сергей , Shpichak Sergey
Published: June 2016

The problems of access control to information and technological resources of automatic control systems for water supply companies are considered. The formalized model of the process of reliable access to information and technological resources is shown. The model takes into account the existence of a multitude of communication channels and a possibility of the organization of the operative cross access. A method to ensure a reliable access to information and technical resources of automatic control systems by water supply companies on the basis of the access policy combination, a scheme of deposit and a preliminary distribution of access authenticators. As a base example there was adopted Blom’s scheme. The method allows ensuring an operative cross access in case of emergency. To ensure an operative access in the method mentioned there was used a scheme of a complete division of a secret in the combination with authenticator evolution. As a basic example the evolution of authenticators based on Lamport’s protocol is considered.
SAFETY RISK ASSESSMENT OF INFORMATION SYSTEMS PROCESSING CONFIDENTIAL INFORMATION
Authors: Шинаков Кирилл , Shinakov Kirill , Рытов Михаил , Rytov Mikhail , Голембиовская Оксана , Golembiovskaya Oksana , Чиркова Ксения , Chirkova Kseniya
Published: June 2016

Confidential information processing in information systems under conditions of the universal informatization in both stateowned and private companies is an urgent problem.

Many operators processing a trade secret or per-sonal data underestimate possible damage caused by the disclosure, deletion or change of confidential in-formation and afterwards become victims either of deliberate criminals or suits of workers whose rights were violated. In such a way, the safety risk assessment of confidential information processed in information systems is a priority trend both for an operator and for a subject of confidential information. As a result of the investigation carried out there was developed a procedure for risk assessment of information systems processing confidential information in which it is possible to define and process a critical group of threats, and also a system for the definition of sufficient and the best set of countermeasures among possible ones. At the intermediate and final stage there is defined a significance of an information safety risk witnessing of measures carried out for the assurance of confidential information safety.
FUZZY COGNITIVE MODELING APPLICATION FOR CARRYING OUT OF INFORMATION SAFETY AUDIT OF INFORMATION PORTALS OF REGIONAL EXACUTIVE AUTHORITIE
Authors: Лексиков Евгений , Leksikov Evgeniy , Рытов Михаил , Rytov Mikhail , Ковалев Павел , Kovalev Pavel
Published: June 2016

At the present moment the internal policy is formed under complicated conditions of foreign situation. The regional policy is formed on the basis of index leveling in socio-economic development. The support of vital functions in social and economic systems of regions plays a role of no small importance in the system of executive power authority (EPA) including regional one. In the interests of assurance of public administration realization it is necessary to have at the disposal a condition for the existence of the vital functions process in social and economic systems. The in-formation portals which perform a role of information and management systems (IMS) have a significant element in the management of social and economic systems of a region. These systems allow performing online information gathering, storage, transfer, analysis and processing regarding a situation changing for deci-sion making. The IMS development makes new re-quirements to the realization of the methodology of process management, taking into account situation changes. The analysis of information flows of regional EPA witnesses of that for management decision making only 10-15% of available information is used to-day.
EFFICIENCY INDICES OF RESOURCE USE AT INDUSTRIAL ENTERPRISES
Authors: Стрижакова Екатерина , Strizhakova Ekaterina
Published: June 2016

The current approaches to the efficiency definition of resource use at industrial enterprises are analyzed. According to existing theories of a firm, in a general case in economy there are emphasized three kinds of efficiency: allocative, adaptive and synergetic. The economic theory of welfare considers the efficiency of resource distribution and use with the application of five paradigms: a utilitarian criterion, criteria of Rawls, Kaldor-Hicks, T. Skitovsky and A. Bergson. For the assessment of a living standard of people the economic science uses a number of factors, such as Gross Domestic Product, National Income, a level of social life development. But their application is possible only at the macrolevel of control. At the level of an enterprise or a sector the group of investment efficiency indices can be used as a basic one. The efficiency in the financial analysis can be estimated with the use of two basic criteria: profitability, profit value. In the paper there are shown values used for the assessment of allocative efficiency of all kinds of re-sources separately – labour, capital, information, hu-man capital. Merits and demerits in the computation of “labour productivity” index are shown. The occurring inaccuracies are presented in the assessment of work done, that resulted in the distortion of the current situation estimate in an industrial system and also in the elaboration of wrong management solutions. The author has offered a set of parameters, an aggregative index – share ratio coefficient of intensive and exten-sive factors for the definition of an allocative efficiency system. In the paper there are presented concepts of adaptive and synergetic efficiency, the existing values of the assessment of the mentioned kinds of efficiency are analyzed are combined into into a single model.
Activity and expression of dipeptidyl peptidase IV on peripheral blood mononuclear cells in patients with early steroid and disease modifying antirheumatic drugs naïve rheumatoid arthritis
Authors: Grujic Milica , Matic Ivana Z. , Crnogorac Marija Djordjic , Velickovic Ana Damjanovic , Kolundzija Branka , Cordero Oscar J. , Juranic Zorica , Prodanovic Slavica , Zlatanovic Maja , Babic Dragan , Damjanov Nemanja
Published: June 2016

Background:

Dipeptidyl peptidase IV (DPPIV/CD26) plays an important role in T cell activation and immune regulation, however the role of this enzyme in early rheumatoid arthritis (eRA) has not been clearly defined. The aim of this study was to determine the serum activity of DPPIV, its expression on peripheral blood mononuclear cells (PBMC) and to examine possible correlations with disease activity (DAS28) in untreated patients with eRA.

Methods:

The study included 50 patients newly diagnosed with RA, who had not received any corticosteroid or disease modifying antirheumatic drugs (DMARD) therapy and whose conventional radiographs of hands and feet showed no structural damage. The control group consisted of 40 healthy volunteers. Also, 30 patients with chronic RA (cRA) were examined. The serum activity of DPPIV was determined by the direct photometric method, while expression of CD26 on PBMC was determined using flow cytometry.

Results:

Decreased DPPIV serum activity was detected in patients with eRA and cRA compared to the control group (p=0.024, p<0.0001, respectively). Although, the percentage of overall CD26+ white blood cells (WBC) was significantly decreased in eRA patients (p<0.001), the percentage of CD26+ lymphocytes and monocytes and mean fluorescence intensity of CD26 on these cells in eRA patients showed no significant difference compared to healthy volunteers. DAS28 showed no significant correlation with CD26 expression or DPPIV serum activity, but a significant inverse correlation between the duration of symptoms and DPPIV serum activity was observed.

Conclusions:

Our results show that a decrease in DPPIV serum activity, but not CD26 expression, is present in an early stage of rheumatoid arthritis.
Moral dilemmas in professions of public trust and the assumptions of ethics of social consequences
Authors: Dubiel-Zielińska Paulina
Published: June 2016

The aim of the article is to show the possibility of applying assumptions from ethics of social consequences when making decisions about actions, as well as in situations of moral dilemmas, by persons performing occupations of public trust on a daily basis. Reasoning in the article is analytical and synthetic. Article begins with an explanation of the basic concepts of “profession” and “the profession of public trust” and a manifestation of the difference between these terms. This is followed by a general description of professions of public trust. The area and definition of moral dilemmas is emphasized. Furthermore, representatives of professions belonging to them are listed. After a brief characterization of axiological foundations and the main assumptions of ethics of social consequences, actions according to Vasil Gluchman and Włodzimierz Galewicz are discussed and actions in line with ethics of social consequences are transferred to the practical domain. The article points out that actions in professional life are obligatory, impermissible, permissible, supererogatory and unmarked in the moral dimension. In the final part of the article an afterthought is included on how to solve moral dilemmas when in the position of a representative of the profession of public trust. The article concludes with a summary report containing the conclusions that stem from ethics of social consequences for professions of public trust, followed by short examples.
Reflections on value education in Slovakia
Authors: Klembarová Júlia
Published: June 2016

This article is devoted to the conception of ethics in Slovakia. Main attention is dedicated to the issue of value education within this subject. It emphasizes the importance of explicit as well as implicit dimensions of value education which represents an important component in the moral development of pupils
Education for active goodness
Authors: Vacek Pavel
Published: June 2016

The present paper focuses on the interconnection and the impact of broader social events responsible for shaping the character of the young in the context of developments in both post-communist countries and the European Union as a whole. The attention of the paper is devoted to the changing perceptions of liberty in relation to a high standard of living in European countries and the need to promote moral education comprehensively, with regard to having a balanced impact on the development of moral knowing and moral feeling. Further, the paper offers an analysis of dimensions that determine moral actions and character accents, considered to be essential to convey in order to encourage the moral development of pupils. Finally, the paper ends with a presentation of the conditions that should help the ethical development of active goodness in the young generation.
Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2′,3,4,4′-tetramethoxychalcones α-Br-TMC and α-CF3-TMC
Authors: Jobst Belinda , Weigl Julia , Michl Carina , Vivarelli Fabio , Pinz Sophia , Amslinger Sabine , Rascle Anne
Published: June 2016

The JAK/STAT pathway is an essential mediator of cytokine signaling, often upregulated in human diseases and therefore recognized as a relevant therapeutic target. We previously identified the synthetic chalcone α-bromo-2′,3,4,4′-tetramethoxychalcone (α-Br-TMC) as a novel JAK2/STAT5 inhibitor. We also found that treatment with α-Br-TMC resulted in a downward shift of STAT5 proteins in SDS-PAGE, suggesting a post-translational modification that might affect STAT5 function. In the present study, we show that a single cysteine within STAT5 is responsible for the α-Br-TMC-induced protein shift, and that this modification does not alter STAT5 transcriptional activity. We also compared the inhibitory activity of α-Br-TMC to that of another synthetic chalcone, α-trifluoromethyl-2′,3,4,4′-tetramethoxychalcone (α-CF3-TMC). We found that, like α-Br-TMC, α-CF3-TMC inhibits JAK2 and STAT5 phosphorylation in response to interleukin-3, however without altering STAT5 mobility in SDS-PAGE. Moreover, we demonstrate that both α-Br-TMC and α-CF3-TMC inhibit interferon-α-induced activation of STAT1 and STAT2, by inhibiting their phosphorylation and the expression of downstream interferon-stimulated genes. Together with the previous finding that α-Br-TMC and α-CF3-TMC inhibit the response to inflammation by inducing Nrf2 and blocking NF-κB activities, our data suggest that synthetic chalcones might be useful as anti-inflammatory, anti-cancer and immunomodulatory agents in the treatment of human diseases.
A personal journey with matrix metalloproteinases
Authors: Nagase Hideaki
Published: June 2016

I was given the honor of delivering the 2015 Lifetime Membership Award lecture at the International Proteolysis Society’s annual meeting held in Penang, Malaysia in October 2015. It gave me an opportunity to look back on how I started my research on matrix metalloproteinases (MMPs) and how I continued to work on these proteinases for the next 42 years. This is a series of sketches from the personal journey that I took with MMPs, starting from the purification of metalloproteinases, cloning, structural studies, then to a more recent encounter, endocytic regulation of matrix-degrading metalloproteinases.
Dynamic targets in the acquisition of L2 English vowels
Authors: Schwartz Geoffrey , Aperliński Grzegorz , Kaźmierski Kamil , Weckwerth Jarosław
Published: June 2016

This paper presents acoustic data on the dynamic properties of the FLEECE and TRAP vowels in the speech of two groups of Polish users of English. Results reveal that the more proficient group users, made up of teachers and professors with professional-level proficiency in English, produce more dramatic patterns of formant movement, reminiscent of native productions, than first year students. It is argued that vowel inherent spectra change (VISC) is an inherent aspect of English phonology, originated in interactions between vowels and neighboring consonants, and later generalized to the vowel system as a whole. By contrast, Polish is a language with a minimal role of VISC. Consequently, successful acquisition of L2 English vowels involves not only the mastery of vowels in F1-F2 space, but also formant trajectories over time.
Direction of Causality Between Financial Development and Economic Growth. Evidence for Developing Countries
Authors: Borlea Sorin Nicolae , Mare Codruta , Achim Monica Violeta , Puscas Adriana
Published: June 2016

The results of extensive studies that analyzed the existence and meaning of correlations between the economic growth and the financial market development lead us to a more thorough study of these correlations. Therefore, we performed a broad study of the developing countries from around the world (the developing part of each region constructed by the World Bank through its Statistics Bureau). The regions taken into analysis were: Europe and Central Asia, South Asia, East Asia and the Pacific, the Arab world, Latin America & and the Caribbean, the Middle East and North Africa, and Sub-Saharan Africa. For comparison purposes, we have also included in the sample the North American countries, the Euro Area and the European Union as a whole, because these last three areas are the main benchmarks of the financial markets. The results are consistent with those from previous studies on the subject and vary depending on region and financial indicator considered.
The Influence of the Macroeconomical Variables on the Bankruptcy Rate of the Romanian Entities Working in the Agricultural Sector
Authors: Rodean (Cozma) Maria-Daciana , Baltes Nicolae
Published: June 2016

The study’s main objective is represented by the analysis of the reasons that lead to the appearance of an agricultural companies’ default risk, based on the failure rate model developed by Wilson. In the construction of the regression model were taken into consideration the evolution of the two macroeconomic variables: the inflation rate and the variation of the exchange rate over a period of 4 years (2010-2013). The research’ results have shown that the variation of the bankruptcy rate registered by the agricultural sector is 99.99% explained by the variation of both of the macroeconomic explanatory variables.
Method of Multiple Scales and Travelling Wave Solutions for (2+1)-Dimensional KdV Type Nonlinear Evolution Equations
Authors: Ayhan Burcu , Özer M. Naci , Bekir Ahmet
Published: June 2016

In this article, we applied the method of multiple scales for Korteweg–de Vries (KdV) type equations and we derived nonlinear Schrödinger (NLS) type equations. So we get a relation between KdV type equations and NLS type equations. In addition, exact solutions were found for KdV type equations. The

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-expansion methods were proposed to establish new exact solutions for KdV type differential equations. We obtained periodic and hyperbolic function solutions for these equations. These methods are very effective for getting travelling wave solutions of nonlinear evolution equations (NEEs).