bluuebunny/crossref_metadata_2025 huggingface dataset:
House Price Prediction and Recommendation
Authors: Mahajan Payal , Gawade Mayur , Patel Aniket , Barhanpurkar Shantanu , Deshmukh Onkar
Published: April 2023

Abstract: Data mining is increasingly frequently used in the housing market. In order to estimate house prices, important housing qualities, and many other things, data mining is quite helpful since it can extract pertinent knowledge from raw data. According to research, the real estate market and home owners are frequently concerned about price variations in housing. To analyse the pertinent characteristics and the best models to forecast home values,a literature review is conducted. The analyses' results supported the usage of the K-Nearest Neighbor and Random Forest Regression as the most effective models when compared to other models. Furthermore, our results imply that structural characteristics and locational characteristics are important predictors of housing prices. To figure out the most significant factors that affect house prices and to recognise the best machine learning model to employ in this field, this study will be of great value, especially to housing developers and academics.
Secure Data Sharing and Search for Cloud Edge Collaborative
Authors: Munot Hitesh , Bettawar Ashwin , Saka Dipen , Langewar Nikhil
Published: April 2023

Abstract: The cloud-edge-collaborative storage (CECS) model is a promising one for handling internet of things data (IoT). It enables edge servers to instantly process IoT data and store it on a cloud server. However, CECS faces the possibility of data leaking as a result of the weakness of edge and cloud servers. Only if all edge servers are trusted are the current secure CECS schemes secure. In other words, all cloud data (produced by IoT devices) will be exposed if any edge server is attacked.It first gives users the ability to create a public-private key pair and take control of their own private keys. The current approach, however, calls for edge servers to control users' private keys. Second, it employs searchable public key encryption to make data searches more safe, effective, and adaptable. In terms of security, our plan guarantees the privacy of cloud data, secure data sharing, secure data searching, and prevents a single point of breach. In particular, when compared to the current secure CECS system, our scheme requires less computing and communication overhead to generate a search trapdoor
Using a Fusion Algorithm for Underwater Image Enhancement, Colour Balancing, Contrast Optimisation, and Histogram Stretching
Authors: Babu Shaik Roshan , Reddy Seelam Laxma , Dogiparthi Tharun Sai , Syambabu Mr.
Published: April 2023

Abstract: For the improvement and restoration of underwater photos, a fusion algorithm is suggested. Histogram stretching, contrast enhancement, and colour balancing are all done. reducing the impact of colour shift, the scalar values of the R, G, and B channels are updated to ensure that the distributions of the three channels in the histogram are consistent. An optimized contrast algorithm is used to establish the best transmittance rather than refining it as is done in dark channel prior based restoration. A histogram stretching approach based on the red channel is presented to further enhance the brightness and contrast of underwater photos. Experimental underwater photos are processed to assess the efficiency of the suggested fusion technique. Research indicates that underwater image quality has greatly improved in terms of both subjective and objective evaluation. The proposed method for processing underwater images is contrasted with a few such methods. Results of comparing show that the chosen approach has an edge over others.
Emotional Abuse in Shashi Deshpande\'s "That Long Silence"
Authors: Bindra Ishleen Kaur , Sharma Kajal , Arora Sakshi
Published: April 2023

Abstract: Indian English Literature has its roots in the works of the 19th century writers such as Bankim Chandra Chatterjee, Rabindranath Tagore, and Sarojini Naidu. In this paper we have reflected mental harassment or emotional abuse through the literary work of famous writer Shashi Deshpande. Her novel “ That Long Silence “ is about a character “Jaya” whose journey of self discovery is a difficult one. She is the victim of the patriarchal society that has denied her the freedom to pursue her dreams. The novel highlights the struggle of women in India. It shows how women are expected to conform to the norms of society and how they are often denied basic rights to make decisions about their own lives. Deshpande encourages women to take charge of their own lives and to be independent and self-reliant.
Study Circle Connect 4U
Authors: Kadam Vedant , Rajput Rahul , Chaudhari Prof. Sonal
Published: April 2023

Abstract: Knowledge is the key resource for most modern organisations. Without a platform to capture and share that knowledge, it’s putting your most valuable asset into the hands of luck. Sometimes, it is possible to meet eminent people online whose interest allign with ours. This system brings people having same interest together by breaking any geographical or social barriers. This Web Application will work as a bridge between people from different areas having same interest and will help to share their wisdom with each other. This Web Application will provide Easy to use User Interface which will bring not only the expert users to the platform but also the beginner level user. This application also tries to keep distraction as low as possible to maintain a closed ecosystem, Chatting, youtube &mock test is a method of using technology to bring people and ideas together despite of the geographical barriers. This system will help people with same interest to express their thoughts and ideas. The system is a project to connect people via all these things while keeping the distraction to the minimal.and if people want to do some relaxtion they can listen music on this web application
Disease Prediction using Python
Authors: Mokal Shantanu Rajesh , Chorghe Darshil Rajendra , Madhavi Neha Jitendra , Kelaskar Pratik Vijay , Jadhav Prof. S. N.
Published: April 2023

Abstract: Disease Prediction based on Symptoms with Machine Learning is a system that predicts diseases based on the user's knowledge of clinical manifestations, ensuring solid conclusions based on such facts. Given how essential the health industry is in treating prescribers' difficulties. This method can be used to learn a little bit about small illnesses if the user only needs to be aware of the illness's basics and the patient isn't in any danger. It's a system that offers clients medical guidance and strategies, as well as a tool to help them identify their illness using this forecast. The healthcare industry as well as those who don't wish to visit a hospital or clinic for their initial diagnosis. By just entering the side effects and other crucial information, the user can learn a great deal about the illness that has been revealed to him or her, and the health sector can profit from this strategy by simply asking the patient for symptoms and providing a diagnosis. We employed machine learning techniques, Python programming with the Tkinter interface, and a dataset collected from hospitals to achieve Illness Prediction based on Symptoms.
Conventional Burnt Clay Bricks Vs AAC Blocks in Construction Projects: A Comparative Study
Authors: Bhattacharjya anindita
Published: April 2023

Abstract: AAC blocks and red clay bricks are two of the more majorly used blocks used in buildings all over the world. Both the block categories have a definite set of pros and cons. A comparative analysis of them is essential to understand and determine which of the two is a superior product, both technically and economically. Experimentation was done on samples of both blocks. Although, some defective set of samples didn’t provide the expected results, it did provide an insight in the technicalities associated with the blocks. It further allowed a comparison between the observed data and the expected data, highlighting how defects within the blocks could affect the properties. Further, some tests were analysed by studying available reports, thesis, articles prepared by various research workers working on the behaviour and properties of AAC blocks and red clay bricks. The overall study proved that AAC blocks, though weaker in compressive strength are much superior in most other properties than the red clay bricks
Differential learning assisted with SANTUY mobile application for improving students’ mathematical understanding and ability
Authors: Rohaeti Euis Eti , Evans Brian R. , Wiyatno Toyo , Prahmana Rully Charitas Indra , Hidayat Wahyu
Published: April 2023

Equations are often used in mathematics and other subjects, which means that a media can teach students how to solve equations, particularly linear equations of two variables, or Sistem Persamaan Linear Dua Variabel (SPLDV) as it is called in Indonesian, is needed. However, most teachers are still focused on developing the learning process and teaching materials rather than developing an application technology-based learning media. As we know that technology-based learning is currently the focus of teaching and learning activities in the digital era, especially learning after the pandemic. This study aimed to develop an application that can be a reference for teaching media in learning activities to improve students’ mathematical understanding and ability. The developed application is named, Integrated and Convenient Android-based Simulation or Simulasi Android Terpadu dan Nyaman, abbreviated as SANTUY. This development study with Analysis, Design, Development, Implementation, and Evaluation (ADDIE) model, explained in detail in the paper, took seventy-five subjects consisting of six expert validators, nine users, and sixty students. The expert validators comprised three media experts and three material experts. The evaluation stage involved students from two groups, each consisting of thirty students. The results showed that the average percentage of the feasibility of the SANTUY SPLDV solution simulation-assisted application with differential learning nuance was 79.62%, which means the application is adequate. The level of usefulness of the SANTUY SPLDV solution simulation-assisted application with differential learning nuance was 86.11%, which is categorized as “excellent”. In addition, using the SANTUY SPLDV application had a direct positive influence on improving students’ mathematical understanding and ability.
Exploring students’ proportional reasoning in solving guided-unguided area conservation problem: A case of Indonesian students
Authors: Sari Yurizka Melia , Fiangga Shofan , Milla Yulia Izza El , Puspaningtyas Nicky Dwi
Published: April 2023

Proportional reasoning has been greatly influencing the development of students’ mathematical abilities. Along with the area conservation ability, it helps elementary students comprehend area measurement. This exploratory study aimed to produce qualitative-descriptive data on elementary students’ proportional reasoning in solving the conservation of plane figures. The study used guided-unguided area conservation problems using a proportional reasoning level as the analysis framework. Data were collected from 4 primary school students in Sidoarjo, Indonesia, who were in fifth-grade class. The students' strategies used were identified to analyze the students' proportional reasoning in solving area conservation. Results show that the level of proportional reasoning varies from zero to two. Regarding the students' proportional reasoning levels, most of the students' strategies use visual clues and cute paste strategies. Only one student can reach the level of quantitative reasoning by using a formula to compare both area measurements. Interestingly, the problem of the conservation of plane figures failed to reveal students' formal proportional reasoning due to their insufficient knowledge of fractions, division, multiplication, and decimals. Some implications regarding students' proportional reasoning and interventions in the area conservation problem are discussed.
Hacia el desmantelamiento de la cárcel. Reflexiones sobre la gestión del crimen, la marginación y la violencia en el sistema penitenciario colombiano
Authors: Mesa Cárdenas William Andrés
Published: April 2023

La cuestión de la prisión implica ser analizada desde una perspectiva de miniaturi-zación social, como una maquinaria panóptica que subyace al control de la insubor-dinación y como una forma de poder molar conectado al sistema represivo estatal. Objetivo: reflexionar sobre aspectos centrales de la cárcel, que pasa por identificar su estructura ideológica y política (política criminal, concepción de la pena, resocializa-ción, aporofobia carcelaria). Metodología: método exploratorio, el cual se caracteriza por su uso en procesos o fenómenos de investigación poco desarrollados o con mínima producción textual. Conclusiones: las cárceles en Colombia son centros de exter-minio, constituyen una forma de prisión cruel, inhumana y degradante, así como una institución de reproducción de las violencias.
Testimonios de la violencia institucional hacia la infancia en residencias bajo la responsabilidad del estado de Chile
Authors: Zúñiga Silva Daniela , Mardones Rodolfo E.
Published: April 2023

La violencia hacia niños, niñas y adolescentes (NNA) que residen en instituciones con tutela del Estado se ha convertido en un tema central en Chile. En la última década se contabilizan más de 210 muertes de niños en estas instituciones. En consecuencia, las residencias de protección son consideradas un escenario altamente riesgoso para sufrir diversos tipos de violencias y un obstáculo para la integración social de NNA. En este contexto, el objetivo de este capítulo es comprender la violencia institucional des-de la experiencia reflexiva de personas adultas que vivieron su infancia en residencias bajo la responsabilidad del Estado. Mediante una aproximación metodológica cualita-tiva exploramos los testimonios que los y las participantes voluntariamente compar-tieron de forma escrita, los cuales fueron analizados en sus contenidos. Los resultados muestran experiencias comunes de violencia sistemática en estas instituciones y sus impactos hasta el presente. Discutimos la violencia institucional como una forma de violencia política, ante la cual los participantes responden a través de sus testimonios. Destacamos la motivación de un cambio social que propone la ruptura de una diná-mica de violencia que contradictoriamente promete protección y reproduce graves violaciones a los derechos humanos.
Study on the permeability of dominant microorganisms in chilled pork under different temperature conditions
Authors: Zhang Yongshun , Huang Xianqing , Song Lianjun , Qiao Mingwu , Shen Yue , Hai Dan , Meng Ziheng
Published: April 2023

Chilled meat has a high water activity and is rich in nutrients, so it
is prone to microbial contamination during industrial production, and
the microorganisms contaminated are widespread and complex. In order to
address its biosafety issues and potential food safety risks, the
experiment was conducted to investigate the variation of dominant
spoilage bacteria in chilled meat under storage conditions of 2 ± 2 ℃,
10 ± 2 ℃, and 20 ± 2 ℃, respectively. At the same time, the variation of
spoilage bacteria in four layers of chilled meat under three temperature
conditions was detected. The results showed that when chilled pork was
stored at 2 ± 2 ℃ and 10 ± 2 ℃, Pseudomonas sp., Thermosporaceae, and
Enterobacteriaceae were the dominant spoilage bacteria in chilled pork,
while when stored at 20 ± 2 ℃, Thermosporaceae, Enterobacteriaceae,
Pseudomonas sp., and Lactobacillus sp. became the dominant spoilage
bacteria in chilled pork; When chilled pork was stored at 2 ± 2 ℃ and 10
± 2 ℃, the order of proliferation of different types of spoilage
microorganisms in the inner layer was as follows: Fusarium
thermophila>Enterobacteriaceae>Lactobacillus>Pseudomonas>Yeast/Yeast>Staphylococcus/
Micrococcus; When stored at 20 ± 2 ℃, the order of the number of
proliferation of different types of spoilage microorganisms is as
follows:
Thermomycetes>Enterobacteriaceae>Lactobacillus
>Yeast/Yeast>Pseudomonas>Staphylococcus/Micrococcus.
Finally, through the change rules of dominant spoilage bacteria under
three temperatures and the penetration of spoilage bacteria in chilled
meat, it provides a theoretical basis for enterprises to improve
precision sterilization and key control point technology.
Importance of biofilm formation for promoting plant growth under salt stress in Pseudomonas putida KT2440
Authors: Gutierrez Stefanie Costa , Raimondo Enzo , Vincent Paula , Cristóbal Ricardo de
Published: April 2023

An underutilized experimental design was used to isolate adapted mutants
of the model bacterium Pseudomonas putida KT2440. The
experimental design consisted of subjecting a random pool of
mini-Tn5 mutants of P. putida KT2440 to several rounds of
selection in the rhizosphere of soybean irrigated with NaCl solution.
Isolated adapted mutants (MutAd) showed a mutation in a gene encoding
the membrane-binding protein LapA, which is involved in the early stages
of biofilm formation on abiotic surfaces. Two MutAd bacteria (MutAd160
and MutAd185) and a lapA deletion mutant were tested to study the
effect of this gene on salt tolerance, rhizosphere fitness,
extracellular polymeric substances (EPS) production, and plant growth
promotion. The inability of the mutants to form biofilm did not hinder
attachment to soybean seeds and roots. MutAd bacteria showed an
overproduction of EPS when grown under saline conditions, which would
compensate for the lack of biofilm formation. MutAd185 bacteria showed
increased root attachment and growth promotion of soybean in slightly
saline soils. The proposed experimental design would be useful to
accelerate bacterial adaptation to the rhizosphere of plants under a
given environmental condition, identify genetic mutations that benefit
bacterial fitness in that condition, and thus increase their ability to
promote plant growth.
Infective endocarditis occurs simultaneously in the native aortic valve and ductus arteriosus
Authors: Wang Jie , Hu Ping , Ku Lei-zhi , Xia Juan , Ma Xiao-Jing
Published: April 2023

A 45-year-old man presented with complaints of intermittent fever and
chest pain for 3 weeks. He had a 30-year history of patent ductus
arteriosus (PDA). Transthoracic- echocardiography (TTE) and
transesophageal echocardiography (TEE) successfully diagnosed aortic
vegetations and cast-type PDAs, but additional PDA terminal vegetations
were found TEE, and PDA vegetations were also found in coronary CT.
Multi model imaging has important value for its accurate diagnosis and
treatment.
Friends or foes? Plant-animal coevolutionary history is driven by both mutualistic and antagonistic interactions
Authors: Fuzessy Lisieux , Balbuena Juan Antonio , Nevo Omer , Tonos Jadelys , Papinot Bastien , Park Daniel , Sol Daniel , Valenta Kim , Razafindratsima Onja , Verdu Miguel
Published: April 2023

Coevolution played a central role in shaping biodiversity. However,
coevolutionary events driving reciprocal diversification between
interacting partners lack empirical evidences. Examples of
diversification arising from mutualisms and antagonisms at different
trophic levels are scarce, which limits our understanding on how complex
relationships between species arise within communities. By adopting a
cophylogenetic framework, we investigated whether congruence in
plant-lemur phylogenies are driven by mutualisms and antagonisms in
Madagascar, where endemic species have evolved within a unique isolated
biogeographical context. Although we found weak support for coevolution,
this is not to say that lemurs and plants did not share evolutionary
history. Weak cophylogenetic signals do not necessarily imply lack of
co-diversification. Rather, our results suggest that vertebrates and
plants influenced each other evolution, but in a multi-specific context
where the cophylogenetic process leaded to spatio-temporal asymmetries
and shifts between periods of coevolution and independent evolution,
ultimately resulting in a weak, continuous and diffuse process.
Seismic risk analysis based on the profile likelihood estimation of the generalized Pareto distribution
Authors: Zhang YanFang , Zhao YiBin , Ren QingQing , Wang FuChang , Qian XiaoShi
Published: April 2023

In this paper, the Seismic risk in the middle of the Bayan Har block
based on the profile likelihood estimation of the generalized Pareto
distribution is studied. Earthquake samples in the middle of the Bayan
Har block in the late 60 years are analyzed. The result shows that the
area experiences an earthquake above 7.0 every 5 years. The theoretical
upper limit of magnitude is 8.7, indicating frequent geological
activities in this area. The profile likelihood estimation is consistent
with the estimation of the maximum likelihood of the parameters. The
confidence interval of the short-term return level is the same for the
two methods. But with the increasing return period, the confidence
interval obtained by the profile likelihood estimation is shifted to the
right as a whole compared to that of the Delt method. The ratio of the
confidence interval length on both sides of the return level will
increase. This asymmetry is effective for the uncertainty of magnitude
prediction.
” The day when the Earth stopped ” – How beliefs in the just world affect emotions and job outcomes during the COVID-19 pandemic: comparisons between Brazil and France
Authors: Queiroga Fabiana , Pérez-Nebra Amalia R. , Lira Eva M. , Angel Vincent , Bertolino Marilena
Published: April 2023

The song alluded in the title could be continued by saying that people
around the countries criticised the measures to contain COVID-19.
Beliefs in a just word (BJW) are related with affective reactions
triggered by extreme events. The aim was to test Affective Events Theory
(AET) by analysing to what extent work environments have influence on
affective experience and job outcomes. Participated 449 teleworkers in
Brazil and 236 in France, countries with similar periods of compulsory
telework, but that adopted different policies. Results revel low
positive emotions tend to decrease perceived job satisfaction when BJW
is high in both contexts. Among French teleworkers, it is also true when
we have high negative emotions. BJW directly affects job performance and
satisfaction in Brazil, but it is only valid for job satisfaction in
France. Results offers support for AET and presents how work
environments indirectly influence affective experience and job outcomes.
Caracterização dos respondentes dos formulários de experiência e opinião das consultas públicas abertas pela Conitec entre 2015 e 2021
Authors: Nogueira Losco Luiza , Prates Sacramento Adriana , Oliveira Almeida Andrija , Moreira Portugal Clarice , Sampaio de Ramos Barros Melina , Brígida de Souza Andrea , Corah Lucas Prado Clementina , Cristina Canuto Santos Vania
Published: April 2023

Objetivo: Caracterizar os participantes que responderam os formulários de experiência e opinião das consultas públicas sobre avaliação de tecnologias em saúde, abertas pela Conitec no período de 2015 a 2021. Métodos: Foi realizada uma análise descritiva quantitativa a partir da compilação e tabulação dos dados sociodemográficos dos participantes das consultas públicas. Resultados: Entre 2015 e 2021, foram abertas 256 consultas públicas para avaliação de medicamentos, 46 de procedimentos e 22 sobre produtos de saúde. Verificou-se que a maior parte dos participantes é composta por familiares, amigos ou cuidadores de pacientes com a doença relacionada à tecnologia em avaliação e que 70% são do sexo feminino. Com relação à idade, 48% dos participantes têm de 25 a 39 anos. A participação por cor/etnia é de 69% de pessoas brancas, 24% pardas, 5% pretas e 2% amarelas. Sobre as Regiões de residência dos participantes, 55% são do Sudeste, 18% do Sul, 17% do Nordeste, 7% Centro-Oeste e 3% do Norte. Conclusão: Observa-se que apesar da criação dos formulários de experiência e opinião, desigualdades no perfil dos participantes ainda existem. Evidenciar esses dados contribui para planejar ações futuras, alinhadas aos princípios de igualdade do SUS e que contribuam para a construção de uma participação plural, no que diz respeito à diversidade etária, racial, de sexo e regional.
Das folhas da Mansoa hirsuta ao desenvolvimento de um curativo para feridas, associado à fração rica em triterpenos pentacíclicos: um dossiê
Authors: Rodrigues Joquebede , De Araújo Moura Lemos Telma Maria , Neves de Lima Ádley Antonini , Goulart Sant’Ana Antônio Euzébio , De Melo Silva Daniel
Published: April 2023

Objetivo: Analisar os estudos já realizados sobre a fração acetato de etila obtida das folhas de Mansoa hirsuta D.C. (FMH) rica em triterpenos pentacíclicos. Métodos: Estudo descritivo e retrospectivo sobre a caracterização química, toxicidade, ações anti inflamatórias e analgésicas e desenvolvimento de filmes de quitosana incorporados com a fração para o tratamento de feridas. Resultados: Observou-se que FMH não comprometeu a viabilidade celular de células 3T3 e em ensaios in vivo de toxicidade aguda e subcrônica não apresentou alterações toxicológicas relevantes. Além disso, não alterou a atividade locomotora e comportamento dos camundongos, nem provocou alteração na coordenação motora e equilíbrio dos animais tratados. Na avaliação da atividade anti-inflamatória, FMH reduziu o edema induzido por carragenina e os níveis de mieloperoxidase e diminuiu a migração de leucócitos e proteínas no modelo de bolsa de ar. Em relação à atividade antinociceptiva, registrou-se redução da contorção abdominal em resposta à administração do ácido acético e inibição da segunda fase do teste de formalina. Nessa perpectiva, curativos contendo a fração foram preparados, caracterizados por métodos fisico-químicos e analisados qanto a sua ação cicatrizante in vivo. Conclusões: Os resultadossugerem um perfil anti-inflamatório e antinociceptivo de FMH, sem causar aparente efeitos tóxicos agudos ou subcrônicos, com uma excelente ação cicatricante, sendo uma fonte promissora a ser explorada no desenvolvimento de propostas terapêuticas para doenças que apresentem esse perfil inclusive a Covid-19. Estes trabalhos geraram depósitos de Patente referente à purificação dos ácidos triterpênicos e do Filme cicatrizante, BR1020150081804 e BR1020190193883 respectivamente.
TBC1D4-S711 Controls Skeletal Muscle Insulin Sensitization After Exercise and Contraction
Authors: Kjøbsted Rasmus , Kristensen Jonas M. , Eskesen Nicolas O. , Kido Kohei , Fjorder Klara , Damgaard Ditte F. , Larsen Jeppe K. , Andersen Nicoline R. , Birk Jesper B. , Gudiksen Anders , Treebak Jonas T. , Schjerling Peter , Pilegaard Henriette , Wojtaszewski Jørgen F.P.
Published: April 2023

The ability of insulin to stimulate glucose uptake in skeletal muscle is important for whole-body glycemic control. Insulin-stimulated skeletal muscle glucose uptake is improved in the period after a single bout of exercise, and accumulating evidence suggests that phosphorylation of TBC1D4 by the protein kinase AMPK is the primary mechanism responsible for this phenomenon. To investigate this, we generated a TBC1D4 knock-in mouse model with a serine-to-alanine point mutation at residue 711 that is phosphorylated in response to both insulin and AMPK activation. Female TBC1D4-S711A mice exhibited normal growth and eating behavior as well as intact whole-body glycemic control on chow and high-fat diets. Moreover, muscle contraction increased glucose uptake, glycogen utilization, and AMPK activity similarly in wild-type and TBC1D4-S711A mice. In contrast, improvements in whole-body and muscle insulin sensitivity after exercise and contractions were only evident in wild-type mice and occurred concomitantly with enhanced phosphorylation of TBC1D4-S711. These results provide genetic evidence to support that TBC1D4-S711 serves as a major point of convergence for AMPK- and insulin-induced signaling that mediates the insulin-sensitizing effect of exercise and contractions on skeletal muscle glucose uptake.
Differential Associations of GAD Antibodies (GADA) and C-Peptide With Insulin Initiation, Glycemic Responses, and Severe Hypoglycemia in Patients Diagnosed With Type 2 Diabetes
Authors: Fan Baoqi , Lim Cadmon K.P. , Poon Emily W.M. , Lau Eric S.H. , Wu Hongjiang , Yang Aimin , Shi Mai , Tam Claudia H.T. , Wong Samuel Y.S. , Lee Eric Kam-Pui , Wang Maggie H.T. , Chu Natural H.S. , Ozaki Risa , Kong Alice P.S. , Chow Elaine , Ma Ronald C.W. , Luk Andrea O.Y. , Chan Juliana C.N.
Published: April 2023

OBJECTIVE

We examined the associations of GAD antibodies (GADA) and C-peptide (CP) with insulin initiation, glycemic responses, and severe hypoglycemia in type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS

In 5,230 Chinese patients (47.6% men) with T2D (mean ± SD age: 56.5 ± 13.9 years; median diabetes duration: 6 [interquartile range 1, 12] years), enrolled consecutively in 1996–2012 and prospectively observed until 2019, we retrospectively measured fasting CP and GADA in stored serum and examined their associations with aforementioned outcomes.

RESULTS

At baseline, 28.6% (n = 1,494) had low CP (<200 pmol/L) and 4.9% (n = 257) had positive GADA (GADA+). In the low-CP group, 8.0% had GADA+, and, in the GADA+ group, 46.3% had low CP. The GADA+ group had an adjusted hazard ratio (aHR) of 1.46 (95% CI 1.15–1.84, P = 0.002) for insulin initiation versus the GADA− group, while the low-CP group had an aHR of 0.88 (0.77–1.00, P = 0.051) versus the high-CP group. Following insulin initiation, the GADA+ plus low-CP group had the largest decrements in HbA1c (−1.9% at month 6; −1.5% at month 12 vs. −1% in the other three groups). The aHR of severe hypoglycemia was 1.29 (95% CI 1.10–1.52, P = 0.002) in the low-CP group and 1.38 (95% CI 1.04–1.83, P = 0.024) in the GADA+ group.

CONCLUSIONS

There is considerable heterogeneity in autoimmunity and β-cell dysfunction in T2D with GADA+ and high CP associated with early insulin initiation, while GADA+ and low CP, increased the risk of severe hypoglycemia. Extended phenotyping is warranted to increase the precision of classification and treatment in T2D.
Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity
Authors: Liu Jia , W. Aylor Kevin , Liu Zhenqi
Published: April 2023

  

Inflammation-induced vascular insulin resistance is an early event in diet-induced obesity and contributes to metabolic insulin resistance. To examine whether exercise and glucagon-like peptide 1 (GLP-1) receptor agonism, alone or in combination, modulate vascular and metabolic insulin actions during obesity development, we performed a euglycemic insulin clamp in adult male rats after 2 weeks of high-fat diet feeding with either access to running wheel (exercise), liraglutide, or both. Rats exhibited increased visceral adiposity and blunted microvascular and metabolic insulin responses. Exercise and liraglutide alone each improved muscle insulin sensitivity but their combination fully restored insulin-mediated glucose infusion rates. The combined exercise and liraglutide intervention enhanced insulin-mediated muscle microvascular perfusion, reduced perivascular macrophage accumulation and superoxide production in the muscle, attenuated blood vessel inflammation and improved endothelial function, along with increased endothelial nucleus translocation of NRF2 and increased endothelial AMPK phosphorylation. We conclude that exercise and liraglutide synergistically enhance the metabolic actions of insulin and reduce vascular oxidative stress and inflammation in the early stage of obesity development. Our data suggest that early combination use of exercise and GLP-1 receptor agonism might be an effective strategy in preventing vascular and metabolic insulin resistance and associated complications during the development of obesity.
Unilateral Strength Training after Total Knee Arthroplasty Leads to Similar or Better Effects on Strength and Flexibility than Bilateral Strength Training – A Randomized Controlled Pilot Study
Authors: Tilp Markus , Ringler Sebastian , Mariacher Herwig , Rafolt Dietmar
Published: April 2023

Objective: Unilateral strength training has been shown to be more effective than bilateral training to increase strength in healthy people. The aims of this study were to test the feasibility of unilateral strength training during total knee arthroplasty (TKA) rehabilitation and compare it with standard bilateral training.Methods: Twenty-four TKA patients from an inpatient rehabilitation programme were randomly assigned to unilateral and bilateral strength training groups. Both groups completed 6 strength training sessions during 3 weeks of rehabilitation. Isometric strength, knee joint flexibility, knee circumference, chair rise and walking abilities, and perceived exertion and pain were assessed before and after the training period.Results: Both training groups increased isometric strength of both legs (+17–25%) and flexibility of the affected leg (+7.6%). Improvements in isometric strength of the healthy leg (+23% vs +11%) and flexibility of the affected leg (+10.7% vs +4.5%) were greater in the unilateral training group. Chair rise and 2-min walk test results improved in both groups, to the same extent. Perceived exertion decreased only in the unilateral training group (–20%), while perceived pain did not change in either group.Conclusion: This study showed the feasibility of unilateral strength training in TKA rehabilitation. Strength and flexibility improved similarly or better with unilateral strength training compared with standard bilateral strength training. Future studies should analyse the efficacy of prolonged unilateral strength training following TKA.
LAY ABSTRACTThe rehabilitation process following a total knee replacement surgery is aimed at regaining strength and flexibility of the knee joint and improving the movements of daily living, such as walking and standing up from a chair. However, to date, it is not known which kind of strength training is most effective in achieving this aim within a rehabilitation programme. During standard rehabilitation, both legs are trained. The current study tested whether training of the affected leg only is feasible, and compared it with standard strength training of both legs. Training the affected leg only resulted in greater improvements in flexibility and similar or greater improvements in strength. Both types of training resulted in improvements in walking and standing up from a chair. In conclusion, strength training of the affected leg only is a feasible alternative to standard strength training with both legs in total knee replacement rehabilitation.
Experimental Validation of Elliptical Contact Patch Tire Model
Authors: Nakanishi Ryota , Matsubara Masami , Ishibashi Takashi , Kawamura Shozo , Tajiri Daiki
Published: April 2023

The influence of tires on vehicle dynamics, as the only automotive component in contact with the road surface, is significant. Mechanical models such as the Fiala model includes tire mechanical properties as parameters and are useful for tire design studies. These models assume a rectangular or trapezoidal tire contact shape, which does not always match the tire contact shape observed when slip angle is applied, leaving room for improvement in accuracy. This study proposes a new semiphysical tire model with an elliptical contact shape, termed the “elliptical contact model.” First, the expressions for the contact shape and contact pressure distributions in the elliptical contact model are formulated. Herein, we consider both the length- and width-direction distributions of the contact pressure in these expressions. Second, the formulation of the lateral shear stress distribution in the contact patch is presented based on the Fiala model, including the belt bending deformation by a lateral force and switching between the lateral shear and dynamic frictional forces. Lateral stresses proportional to the width coordinate are also introduced, enabling the calculation of lateral stresses acting in a direction counteracting each other at the widthwise edge of the tire contact surface. The model is validated by measuring a slick tire at a velocity of 100 km/h with slip angles of 0° and 3° using an Inside Drum Machine with an aluminum road segment with quartz piezoelectric sensors. Consequently, by setting appropriate model parameters, the contact pressure and lateral shear stress distribution results calculated using the model are consistent with experimental results. The accuracy of the proposed model could be further improved by revising the method of setting the static and dynamic friction coefficients.
Pemanfaatan Biji Lamtoro untuk Pembuatan Kecap dan Pemberdayaan Kelompok PKK di Desa Kaliploso Cluring, Banyuwangi
Authors: Rachmah Alif Nur Laili , Susanti Yuni , A’yun Ayu Qurota , Ansori Ansori , Sekaringgalih Ratri
Published: April 2023

The community service program carried out in Kaliploso Village, Cluring District, Banyuwangi Regency is a sharing of knowledge from chemical engineering lecturers and students to the community. The aim of implementing this program is to increase the creativity of the Kaliploso community by using lamtoro seeds as an alternative to soybeans as the basic ingredient for making soy sauce with the addition of special spices. The program implementation method begins with outreach, training in making soy sauce, fostering independent production, to monitoring, and evaluation. First, socialization to the community regarding the natural potential in Kaliploso village, especially on the nutritional content of lamtoro seeds, secondly, training on making lamtoro soy sauce is explained in detail regarding the composition, tools used, and the stages of the soy sauce making process, thirdly, assistance and encouragement for independent production to participants who have formed 4 groups to make lamtoro soy sauce at home, the last stage is monitoring and evaluation carried out to measure the level of success of the program for utilizing the natural potential and community empowerment through training in making lamtoro soy sauce. The impact of the program that has been carried out can ignite the community to be more productive, create products that can add economic value and promote prosperity in Kaliploso village, and the soy sauce product "Cap Roso" which is produced as a product the hallmark of  Kaliploso village for more known by outsiders.
Pulmonary AVM and Stroke: Case Report from Istishari Arab Hospital
Authors: Smerat Sami , Adwan Samir , Khatib Mohammed , Owenian Haneen F. , AlFaqih Khalid
Published: April 2023

Background: Pulmonary arteriovenous malformation (PAVM) is an abnormal communication between pulmonary artery and pulmonary vein which leads to multiple manifestations that range from hypoxia to neurological manifestation such as stroke due paradoxical emboli in young patients. Chest radiography and CT-enhanced studies help in diagnosis with pulmonary angiography which is considered the gold standard study for diagnosis. Management was done with embolization of the feeding artery or arteries.

Case: A 31 year old female with no previous history of medical illness, presented with sudden onset left sided weakness and was diagnosed as a case of right sided ischemic stroke. After reviewing her case by multidisciplinary team and multiple imaging studies, pulmonary angiography showed that the patient had large right lower lung lobe PAVM in addition to another right middle lung lobe and left lower lung lobe smaller PAVM. After that, patient underwent embolization of with no complications.

Conclusion: PAVM, although it is rare, should be considered in differential diagnosis as the cause of neurological manifestation as ischemic stroke in young patients by paradoxical emboli. Embolization of the feeding artery or arteries is the main treatment of PAVM.
EFL SPEAKING STUDENT READINESS TO USE MOBILE-ASSISTED LANGUAGE LEARNING
Authors: Assapari Muhammad Mugni , Hidayati Rosyadi
Published: April 2023

In recent years, mobile-assisted language learning has been on the rise as an instructional approach. While some innovative media platforms have been highly studied, Thus, this study focused on how students' readiness and learning outcomes the use of mobile phones to facilitate individualized instruction in public speaking as part of an English as a Foreign Language course. Data were collected from (n=42) students in non-English department classes who participated in this study. They were asked to answer an online questionnaire that surveyed their readiness and outcomes using Google Foam in their speaking skills. All participants performed two class projects aimed at aiding them in exploring mobile-assisted language learning using their own mobile devices. However, the students self-reported some opportunities and benefits for English Foreign Language Learners (EFLL) among these MALL users. The results of this study suggest that EFL-speaking students' readiness affects mobile-assisted language learning. Teachers should consider students' motivation, attitudes, and technology skills when creating mobile-assisted language learning programs. Instructors should also train and motivate pupils to use mobile-assisted language learning resources by improving their technology skills. Furthermore, need for further technical support and facilitating students' mastery of speaking performance.
As traduções e recontextualizações da BNCC e do Referencial Curricular Gaúcho nos anos iniciais do ensino fundamental
Authors: Monte Freitas Fabrício , Alberto da Silva João
Published: April 2023

O presente artigo tem como objetivo estabelecer relações entre a Base Nacional Comum Curricular (BNCC) e o Referencial Curricular Gaúcho (RCG), buscando compreender as transformações ocorridas no decorrer das traduções realizadas, em especial nos anos iniciais do ensino fundamental. A pesquisa é documental e a análise dos dados é de caráter descritivo. As informações presentes nos documentos analisados foram sistematizadas e organizadas valendo-se de três eixos emergentes: 1) democracia e participação; 2) identidade; e 3) ausências. Em seguida, passa-se a discutir as habilidades e as traduções realizadas no âmbito das áreas do conhecimento. Após a análise dos documentos e, com base nas teorias de Basil Bernstein e Jose Gimeno Sacristán, conclui-se que o RCG, em alguns casos, apresenta reescrita das habilidades previstas na BNCC, alterando a ordem das palavras, sendo uma tradução do documento nacional com poucas recontextualizações. Com isso, entende-se que a BNCC, que deveria ser um documento orientador, acaba por se tornar o próprio currículo devido à forte classificação exercida frente às traduções realizadas, como o RCG.
A criança negra e os documentos publicados pelo Ministério da Educação no período de 1960 a 2000
Authors: Dejane Silva de Oliveira Anatália , Fernandes Santos Nogueira Ari
Published: April 2023

Este artigo é resultado de investigação por meio de documentos publicados pelo Ministério da Educação (MEC) entre 1960 e 2000, com o objetivo de identificar o lugar da criança negra nesses documentos oficiais destinados à orientação para a educação pré-escolar. Ao mostrar a invisibilidade das relações étnico-raciais nesses documentos oficiais por quase quatro décadas, o estudo contribui para reconhecer que as produções científicas sobre infância e educação infantil no contexto histórico da educação brasileira são pressupostos teórico-metodológicos necessários para incluir a diversidade racial na organização do trabalho pedagógico da educação infantil. Desenvolveu-se pesquisa teórica do tipo análise documental com base num conjunto de publicações do MEC no período citado, cujos dados foram agrupados em temáticas para mostrar a dinâmica da educação pré-escolar entre 1960 e 1980, posteriormente denominada educação infantil, nos anos 1990. Em ambos os contextos, observa-se que, durante décadas, foi explícita a negação da criança negra nos documentos, situação que se rompe somente em 1997, com a primeira publicação nacional endereçada à creche.
Farklı Taban Suyu Derinliği ve Tuzluluğu Koşullarında Şeker Mısırı (Zea mays convar. Saccharata var. Rugose) Bitkisinin Büyüme Performansı
Authors: KİREMİT Mehmet , OSMAN Hussein Mohamed , ARSLAN Hakan
Published: April 2023

Bu çalışmada, şeker mısırı bitkilerinin 3 farklı taban suyu derinliği (30 (D1), 55 (D2) ve 80 (D3) cm) ve 3 farklı taban suyu tuzluluğu (0.38 (T1), 5 (T2) ve 10 (T3) dS m-1) koşullarında büyüme performanslarının belirlenmesi amaçlanmıştır. Deneme, tesadüf blokları deneme desenine göre 3 tekerrürlü olarak yağmurdan korunaklı 120 m2’lik alanda drene edilebilir lizimetre koşullarında yürütülmüştür. Çalışma sonucunda, taban suyu derinliği arttıkça mutlak büyüme oranı, nispi büyüme hızı, net asimilasyon oranı, bitki büyüme hızı, özgül yaprak alanı ve oransal yaprak alanı artmıştır. Ancak, taban suyu tuzluluğu arttıkça şeker mısırı bitkilerinin büyüme performansları önemli derecede azalmıştır. Çalışmada, mutlak büyüme oranı 1.51-2.37 cm g-1, oransal yaprak alanı 69.48-90.96 cm2 g-1 ve net asimilasyon oranı 0.12-0.17 mg cm-2 g-1 arasında değişmiştir. En yüksek özgül yaprak ağırlığı değeri 215.69 cm2 g-1 ile D3 konusunda elde edilirken en düşük değer ise 200.07 cm2 g-1 ile D1 konusunda elde edilmiştir. En düşük bitki büyüme parametreleri değerleri D1×T3 , en yüksek değerler ise D2×T1 konusunda tespit edilmiştir. Bununla birlikte, taban suyu derinliği <55 cm’den daha az ve taban suyu tuzluluğu 5 dS m-1’den daha yüksek olan bölgelerde şeker mısırı bitkilerinin gelişiminin önemli derecede azaldığı belirlenmiştir. Buna göre, şeker mısırı bitkilerinin taban suyunun tuzlu ve 30 cm derinlikte olduğu koşullara karşı düşük toleransa sahip olduğu belirlenmiştir. Sonuç olarak, şeker mısırı için yüksek bitki büyüme performansı değerleri taban suyu derinliğinin 55 cm ve taban suyu tuzluluğunun 0.38 dS m-1 olduğu koşullarda gözlemlenmiştir.
E-LEARNING MOTIVATION AMONG STUDENT-ATHLETES OF UNIVERSITI TEKNOLOGI MARA (UiTM), MALAYSIA.
Authors: Parnabas Vincent , Abdullah Nagoor Meera , Mohamed Shapie Mohamad Nizam , Abdul Rahim Mohamad Rahizam , Parnabas Julinamary , Parnabas Antoinette Mary , Isa Mona , Indrakisyah Mohamad
Published: April 2023

The greatest challenge for educators during the pandemic Covid 19 situation today is to motivate their students to adopt e-learning. Therefore, it is important for lecturers in higher institutions to understand how to motivate their learners in choosing the types of motivation. Motivation refers to the concern with arousal, direction and persistence of behaviour towards the achievement of a specific goal, which classified into intrinsic and extrinsic. The objective of this study is to explore the types of motivation in adopting e-learning among the student-athletes of Sport Science and Recreation Faculty at University Technology MARA (UiTM), Malaysia. One hundred and twenty student t- athletes participated in this study. They were categorized into four ranking known as national, state, district and university based on their achievement in sports. The overall result showed that the student-athletes have the highest level of motivation in External Regulation (mean= 27.51), followed by Introjected Regulation (mean= 25.74), Identified Regulation (mean= 22.32), Amotivation (mean= 20.34), Intrinsic Motivation to Experience (mean= 17.17), Intrinsic Motivation to Know (mean= 15.31) and Intrinsic Motivation to Accomplish (mean= 12.55). Furthermore, national level athletes scored higher mean in both types of e-learning motivation except for Amotivation. In contrast, university ranking student-athletes scored the lowest on all the types of motivations for e-learning but highest in Amotivation. The findings obtained in this study supported by Self-Determination theory that e-learning involves the interaction of both intrinsic and extrinsic motivation. Therefore, educators should use intrinsic and extrinsic types of motivation to enhance the e learning habits among student-athletes to increase their performance in academic.