bluuebunny/crossref_metadata_2025 huggingface dataset:
Activimeter “in situ” calibration methodology to 111In and 123I
Authors: Martins Elaine Wirney , Potiens Maria da Penha Albuquerque
Published: July 2023

The activimeter calibration has the purpose of ensure greater reliability in measurement results, hence the activimeters used are commonly installed in controlled areas and, in some cases, with difficult access. The activimeter “in situ” calibration methodology presented in this work allows its execution only with the displacement of the radioactive samples and not of the activimeter itself, which simplifies the procedure of nuclear medicine services and at radiopharmaceuticals production centers, without affecting the quality and accuracy of measurements. After the application of the methodology by qualified technicians, the obtained results of the tested activimeters showed its importance since the calibration factors can present correction of up to 5% for 111In and greater than 5% for 123I.
La integración documental de la contabilidad del Erario regio del Nuevo Reino de Granada a finales del siglo XVIII. El caso de la caja real de Cartago (1798)
Authors: Sánchez Santiró Ernest
Published: July 2023

El artículo muestra la integración documental que en materia contable desplegó el Erario regio del Nuevo Reino de Granada a finales del siglo XVIII. Para ello se realiza un estudio de caso a partir de la caja real de Cartago, con base en la documentación contable que tuvo que presentar el oficial real de dicha tesorería ante el Tribunal de Cuentas de Santafé de Bogotá en 1798. Un procedimiento que permite observar la estructuración jerárquica y el control que había logrado la autoridad fiscal a partir de la supervisión contable.
“Es mejor ser con miedo que dejar de ser por miedo”. El movimiento de mujeres de Barrancabermeja y la masacre del 16 de mayo de 1998
Authors: Acevedo Tarazona Álvaro , Mejía Jerez Yuly Andrea , Correa Lugos Andrés David
Published: July 2023

Este artículo analiza el papel del Movimiento de Mujeres contra la Guerra y por la Paz (MMGP) en la construcción de memoria y resistencia desde el feminismo popular. El artículo estudia el caso de la masacre del 16 de mayo de 1998 en el barrio el Campin de Barrancabermeja para develar la contribución de las mujeres en la defensa de la vida y del territorio, así como a la re-significación del trauma social. Para ello aplica una metodología cualitativa con observación participante, entrevistas semi-estructuradas a mujeres de la Organización y revisión de fuentes secundarias.
Investigation of thermal mode of hot-rolling mill working rolls in order to improve the accuracy of calculating the thermal profile of their barrels’ surface
Authors: Shalaevskii D. L.
Published: July 2023

Thermal mode of the working roll barrel in a hot-rolling mill is a significant technological factor that affects the steel strip quality, its cross section, and durability of working rolls. A reliable calculation of the temperature mode parameters makes it possible to determine the thermal profile shape and the best profiling of the roll barrel surface, as well as to reduce defects in steel strip flatness. The most common is the balance model of roll thermal mode. Its accuracy is largely determined by thermophysical constants, in particular, the heat transfer coefficients of the rolls: contact – with the strip and convective – with cooling water. There are various data on the values ​​and methods for calculating these coefficients, but most of them do not take into account the presence of pauses in rolling rhythm of the finishing group of stands, the duration of which is significant. Failure to take this factor into account entails significant errors in calculations of the thermal mode. A passive experiment was carried out, during which surface temperatures of the working rolls’ barrels were measured using a thermocouple at several points along their length immediately after they fell out. Also, the parameters of steel strip rolling before roll change were determined: rolling rhythm coefficients, strip reduction in stands, water consumption for cooling rolls and some others. As a result, an empirical equation was obtained for calculating the contact heat transfer coefficient, taking into account the main technological factors. The use of refined coefficients for calculating the temperatures of the roll barrel significantly increased the accuracy of predicting the thermal mode, in particular, the thermal profile of the working roll, based on values ​​of the rolling parameters.
Electrospark deposition of metalloceramic Fe–Al/HfC coating on steel 1035
Authors: Burkov A. A. , Kulik M. A.
Published: July 2023

To improve the tribotechnical behavior and heat resistance of steel 1035, composite metalloceramic Fe–Al/HfC coatings were prepared by electrospark deposition. A non-localized anode was used as an electrode consisting of a mixture of iron and aluminum granules with a molar ratio of 3:2 and with the addition of HfC powder. The cathode gain had positive values indicating that HfC powder can be deposited on steel 1035 using the Fe60Al40 anode mixture. Moreover, the cathode gain monotonically increased with the increase in addition of HfC powder to the anode mixture. The coatings structure is represented by a matrix of FeAl intermetallic compound reinforced with HfC grains, which corresponds to the structure of a metalloceramic composite. Concentration of HfC in the coating increased with the addition of HfC powder to the anode mixture. Deposition of Fe–Al/HfC coatings according to the proposed technique allows reducing the friction coefficient of steel 1035 from 6 to 40 vol. %. Depending on the concentration of HfC in the anode mixture, the wear resistance of Fe–Al/HfC coatings varied nonmonotonically with a maximum at 8 vol. %. The use of Fe–Al/HfC coatings makes it possible to increase the wear resistance of the steel surface to 10 times. Comparison of the final weight gain of the samples after 100 h of oxidation resistance tests at a temperature of 700 °C allows us to conclude that electrospark deposition Fe–Al/HfC coatings can increase the oxidation resistance of steel 1035 by 1.7–2.2 times. Analysis of the study results shows that adhesion of Fe–Al composition to HfC is weak. This was reflected in decrease in hardness, wear resistance and oxidation resistance of coatings with an increase in the concentration of HfC in the anode mixture above 8 vol. %.
Justification of the strategic priorities of raising investment attractiveness of housing construction (on the example of Moscow city case study)
Authors: Rubes M. A. , Alimuradov M. K.
Published: July 2023

Successful justification of strategic priorities in housing construction is vital for the comprehension of development of territorial zoning and urban infrastructure. Also, it satisfies a number of people’s needs which can be observed in renovation of the housing stock and creation of investment infrastructure for attracting external and internal capital. At the same time it is essential to understand that in the context of state and municipal administration the strategic priority for state and business interaction is meeting the needs of both parties. That is the reason why the strategy of development and improvement of the city is of vital importance from the viewpoint of the comfort of life and improvement of the quality of urban infrastructure. And in order to attract investors to the realization of construction projects in which the authorities are primarily interested it is necessary to create additional preferences. Due to the fact that profitability of mass housing construction projects is rather low but it forms the main demand among the population, taking into account the factors of comfort and integration into the urban environment, the authors decided to study and justify the existing trends in the development of large megacities with the consideration of the regional factors and justify strategic priorities for raising investment attractiveness of construction objects for investors.
621.1.HTC_H&E Stain (Paraffin or Cryosections) v2
Authors: S Pryhuber Gloria
Published: July 2023

Hematoxylin and Eosin staining is the standard chemical stain used on slides to be reviewed for assessment of general histopathology and the generation of a pathology report for each donor. (From Wikipedia) H&E is the combination of two histological stains: hematoxylin and eosin. The hematoxylin stains cell nuclei a purplish blue, and eosin stains the extracellular matrix and cytoplasm pink, with other structures taking on different shades, hues, and combinations of these colors. Hence a pathologist can easily differentiate between the nuclear and cytoplasmic parts of a cell, and additionally, the overall patterns of coloration from the stain show the general layout and distribution of cells and provides a general overview of a tissue sample's structure. Pattern recognition, by expert humans or by software that aids those experts in digital pathology, provides histologic information. This stain combination was first introduced in 1876 by A. Wissowzky.
Impact of physical activity on the quality of life of pregnant women
Authors: Zakharov Igor S. , Shmidt Аndrey A. , Satushkina Ekaterina Yu. , Bondareva Valeria S. , Ivanov Vadim I. , Andrianova Evgeniуa V. , Fesenko Tatiana V. , Karpishchenko Zhanna M. , Morozova Galina Yu.
Published: July 2023

AIM: To study the effect of physical activity on the quality of life of pregnant women at various gestational ages.
MATERIALS AND METHODS: An observational cross-sectional study of physical activity and quality of life was performed in 99 pregnant women at various gestational periods. Criteria for inclusion in the study: age 1835 years; absence of acute extragenital pathology; consent to conduct research. Exclusion criteria: age younger than 18 and older than 35 years, the presence of acute extragenital pathology; lack of consent to participate in the study. To assess the physical activity of pregnant women, the international Pregnancy physical activity questionnaire (PPAQ), consisting of 36 questions, was taken as a basis. In order to study the quality of life, an abbreviated methodology of the World Health Organization WHOQOL-26 (World Health Organizations Quality of Life), including 26 questions, was used.
RESULTS: To achieve this goal, an adapted Russian-language version of the international questionnaire was developed that determines the level of physical activity in pregnant women PPAQ-RUS, on the basis of which a computer program was created. In the study, data were obtained on the statistically significant effect of a number of parameters of physical activity on the quality of life at various times of the gestational period. The correlation of professional activity with self-perception and the level of physical and psychological well-being, as well as activity associated with physical exercises, indicators of physical and psychological well-being was determined.
CONCLUSION: The conducted study can be the basis for further study of the influence of the level of physical activity of pregnant women on the course of the gestational period, as well as the study of the possibility of managing the quality of life of women by changing physical activity depending on the duration of pregnancy.
A Retrospective, Cross-Sectional, Descriptive Research: Evaluation of Traumatic Respiratory Impairment Cases That Were Sent to the Turkish Council of Forensic Medicine 3rd Speciality Board in 2020
Authors: Efil Hakan , Aydoğdu Halil İlhan , İçmeli Özlem Saniye , Küçük Ceyhun , Bakır Küçük Pınar
Published: July 2023

Objective: It is important to determine whether there is a long-term loss of respiratory function in people who have had thoracic trauma, both in respect of the clinical follow-up of cases and in judicial terms (punishment/compensation). The aim of this study was to examine the data related to the nature of trauma and sequelae associated with the respiratory disability of trauma origin, and by reviewing the basis of sequela evaluation, to contribute to future clinical studies to reduce morbidity in thoracic trauma patients and to specialists working in the field of disability.
 Methods: A retrospective review was performed by examining the medical records of cases with thoracic trauma referred for evaluation of disability following trauma (workplace accident, assault, traffic accident). The data were retrieved from the electronic database.
 Results: The ages of the cases included in the study ranged from 8 to 84 years, with a median age of 44. When the gender distribution was evaluated, it was seen that 85.3% of the cases were male (n=133), and 14.7% were female (n=23). As a result of all the evaluations, it was determined that 10 (6.4%) cases had a loss of pulmonary function due to thoracic trauma, and the disability rate was determined.
Conclusion: As evaluation made on the basis of test results or examination findings alone when determining respiratory function losses can be erroneous, the decision must be made with examinations in specialized centers by experienced physicians guided by respiratory function tests and assistive and supportive imaging results.
Kaza İhmali mi - Yoksa İhmal Kazayı mı Aklımıza Getirir? - Olgu Sunumu
Authors: Aslan Fatmagül , Yaşar Teke Hacer , Kıhtır Hasan Serdar , Pakiş Işıl
Published: July 2023

In this study, a child case who was admitted to the hospital with a history of falling from a height, and forensic medical consultation was requested due to a conflict between severe clinical findings and history, will be presented and attention will be drawn to the fact that abuse and neglect can underlie every accident, especially in children. A 3-year-old girl was referred to the hospital by her refugee family with a history of falling from a height of 4 meters onto a concrete floor at noon. Childhood physical traumas are situations that need to be investigated thoroughly, may be caused by neglect and abuse, and a multidisciplinary approach should be exhibited. In this regard, child health professionals; they can play important roles in many stages, from prevention, reporting and treatment to child protection and monitoring services.
Prescripción del ejercicio por médico de atención primaria en paciente adulto sano
Authors: Rodriguez Villaquiran Nicolle Andrea , Chaustre Ruiz Diego Mauricio
Published: July 2023

La inactividad física es un estilo de vida que se ha venido acoplando de manera significativa en la población durante los últimos años y el compromiso cardiovascular inherente a esta falta de actividad es uno de los factores de riesgo más grandes que deben enfrentar los profesionales de la salud. Desde la consulta al médico de atención primaria realizar una adecuada prescripción del ejercicio en el adulto sano puede maximizar los múltiples beneficios de la actividad física y reducir el riesgo cardiovascular y los factores que puedan contribuir al desarrollo de diversas enfermedades crónicas no transmisibles. Objetivo y metodología: con el fin de orientar al profesional de la salud en este proceso de prescripción de una manera adecuada y fundamentada se realiza una revisión de la literatura sobre los conceptos básicos de la actividad física y el ejercicio, el principio Frecuencia, Intensidad, Tiempo y Tipo (FITT), el método de abordaje del paciente y la estructuración de un plan básico de ejercicio que cumpla con las recomendaciones estipuladas por la Organización Mundial de la Salud. Conclusión: la promoción de la actividad física de manera correcta por medio de la comprensión de conceptos relacionados para la prescripción del ejercicio permitirá a los médicos de atención primaria contribuir activa y acertadamente a los Objetivos de Desarrollo Sostenible estipulados para 2030 desde la salud y el bienestar.
Yield and quality of potato tubers when grown in organic farming conditions
Authors: Loginov Yu. P. , Kazak A. A. , Gayzatulin A. S.
Published: July 2023

Methodology. The purpose of the research: to study the yield and quality of tubers of early ripe potato varieties Charoit and Meteor in organic farming in the northern forest-steppe of the Tyumen region. Studies were carried out in 2019- 2022 on the experimental field of the Northern Trans-Ural State Agricultural University. The soil of chernozem is leached, heavily carbonaceous in grain size distribution, medium provided with nitrogen and phosphorus, good – potassium, pH – 6.7 humus content – 7.2%. The content of trace elements in the soil is satisfactory. The precursor is spring wheat + rape per siderate. The green mass of the sideral culture (170 c/ha) was smelled on the fifth of October. In the spring, harrowing was carried out in order to retain moisture in the soil, then at a temperature of + 10…+12°C at a depth of 10-12 cm, milling, cutting of ridges and planting with sprouted tubers were carried out. The landing scheme is 75x30 cm, the plot area is 50 m2, the accounting one is 30 m2, the repetition is four times, the location of the plots is rendered. Prior to planting, tubers were treated with Taboo, 1 L/t and growth bioregulator Rostock, 0.5 L/t, and plants were treated with Immunocytophyte, 0.5 g/ha during the budding phase. Mineral fertilizers were not contributed. Caring for potato plantings included two interrow treatments and sinking.Results. It was established that in potato crop rotation with the annual use of sideral fertilizers, the yield of the noted varieties averaged 21.7-22.0 t/ha over four years, or 1.1-1.4 t/ha higher than the Zhukovsky early standard. The yield was combined with high quality tubers: starch content 13.9-14.6%, vitamin "C" 15.6-16.4 mg/%, nitrates – 59-81 mg/100 g, taste rating – 4.1-4.3 points.
Obtaining and evaluating breeding material for the creation of F1 hybrids of Chinese cabbage (B. rapa ssp. pekinensis) with resistance to stress factors
Authors: Zastavnyuk A. D. , Monakhos G. F. , Monakhos S. G.
Published: July 2023

Relevance and purpose of the study. Chinese cabbage is a vegetable crop with a high content of vitamins and low calorie content, valued for its ability to receive several crops per year and high productivity. Recently, there has been a reduction in the supply of the vegetable to Russia. There are less than 70 varieties and hybrids of the crop in the State Register of Selection Achievements, many of them are susceptible to the most important diseases. It is necessary to meet consumer demand with new commercial hybrids with resistance to stressors. The aim of the study was to evaluate and obtain genotypes with a set of valuable economic traits, including resistance to clubroot, powdery mildew, and early bolting.Materials and methods. The Chinese cabbage lines of various degrees of inbred and DH, as well as hybrid combinations from crossing these lines, were used as plant material. The lines were obtained in 2019-2020, the breeding material for them was selected on the ground infected with clubroot and with tolerance to tip burn of heads. To achieve the goal, the following methods were applied: plants cultivation; DNA isolation (CTAB method); PCR analysis; electrophoresis and visualization of results; productivity assessment and dispersion analysis; obtaining doubled haploids in culture of isolated microspores in vitro, assessment of resistance/susceptibility to powdery mildew.Results. 2 genotypes with high productivity and alignment in turnover summer-autumn 2022 and a genotype exceeding 3 standards in head weight in turnover spring-summer 2022 were recommended; as a result of molecular genotyping, 41 lines were differentiated according to the clubroot resistance gene CRb; DH plants for 4 genotypes with resistance to early bolting were obtained, their responsiveness to embryogenesis was studied; 18 lines were evaluated for resistance to powdery mildew, 7 genotypes with resistance to the disease were identified.
fim do impresso e a disputa de sentidos entre os jornalistas sobre a interrupção de circulação do jornal Diário do Nordeste
Authors: Costa Rafael Rodrigues da , Silva Naiana Rodrigues da
Published: July 2023

Este artigo tem como objetivo identificar os sentidos postos em circulação pelos discursos de jornalistas e do jornal Diário do Nordeste em razão do anúncio do fim de circulação da versão impressa do referido jornal. Para tanto, realizamos uma análise discursiva de editoriais e reportagens publicados pelo Diário do Nordeste sobre o fato e de postagens de 16 jornalistas na plataforma de rede social Instagram. Verificamos a manutenção do ethos discursivo de modernização tecnológica do jornal (SILVA, 2011) e da evocação de uma memória discursiva (PÊCHEUX, 1999) sobre o jornalismo para qualificar a interrupção de circulação do impresso, a qual assume diversos sentidos, por exemplo, sendo apontada como inerente às transformações produtivas contemporâneas e como uma ameaça à profissão.
Linguistic sensory of the interlocutor’s image in H. Boll’s novel “The Clown”
Authors: Shemchuk Yuliya M. , Spanopulo Margarita V.
Published: July 2023

The purpose of study is to describe the sensory features of interlocutor’s perception by the main character of the novel by H. Boll “The Clown”. Sensory vocabulary representing odors, skin reactions and color combinations of clothes perceived by the protagonist of the analyzed work of art is chosen as the study material. The novelty of study lies in the fact that for the first time the verbalization features of olfactory associations in the novel by H. Boll “The Clown” are considered; for the first time, a quantitative analysis of lexemes-representatives of skin reactions is carried out in it; for the first time, the colouronyms that serve to describe the colour combinations of characters’ clothes in the novel are analyzed. The methodological basis of this study is the linguoculturological approach, which made it possible to interpret the results obtained in the cultural aspect. The relevance of work is determined by its purpose and the active development of linguistic sensory as a new direction of linguistic research. The analysis of the lexical means of expressing the interlocutor’s sensory perception in one particular work of art should be considered as a kind of contribution to the development of linguistic sensory. Sensory vocabulary allows us to expressively describe the internal state of the characters, their experiences, feelings, emotions, form their psychological portraits based on odors, skin reactions and perception of color combinations in clothes. The work may be of interest to specialists in the field of German studies, psycholinguistics, linguistic semantics, intercultural communication, cultural linguistics. Linguistic analysis of sensory vocabulary of works of art by other German-speaking authors seems promising, taking into account its cultural context.
Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis
Authors: Singh Amit , Shee Somnath , TV Reshma , Mohanraj Karthikeyan , Das Mayashree , Malhotra Nitish , Bandopadhyay Devleena , Beig Hussain , Birua Shalini , Niphadkar Shreyas , Nagarajan Sathyanarayanan , Sinha Vikrant Kumar , Thakur Chandrani , Rajmani Raju , Chandra Nagasuma , Laxman Sunil , Singh Mahavir , Samal Areejit , Seshasayee Aswin Sai Narain
Published: July 2023

Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic metabolism, understanding how Mtb manages eROS levels is essential yet needs to be characterized. By combining the Mrx1-roGFP2 redox biosensor with transposon mutagenesis, we identified 368 genes (redoxosome) responsible for maintaining homeostatic levels of eROS in Mtb. Integrating redoxosome with a global network of transcriptional regulators revealed a hypothetical protein (Rv0158) as a critical node managing eROS in Mtb. Disruption of rv0158 (rv0158 KO) impaired growth, redox balance, respiration, and metabolism of Mtb on glucose but not on fatty acids. Importantly, rv0158 KO exhibited enhanced growth on propionate, and the Rv0158 protein directly binds to methylmalonyl-CoA, a key intermediate in propionate catabolism. Metabolite profiling, ChIP-Seq, and gene-expression analyses indicate that Rv0158 coordinates metabolic neutralization of propionate toxicity by regulating the methylcitrate cycle. Disruption of rv0158 enhanced the sensitivity of Mtb to oxidative stress, nitric oxide, and anti-TB drugs. Lastly, rv0158 KO showed poor survival in macrophages and persistence defect in mice. Our results suggest that Rv0158 is a metabolic integrator for carbon metabolism and redox balance in Mtb.
Persistent organic pollutants profile of sediments from marine protected areas: the Northern Persian Gulf
Authors: Ghaemi Maryam , Soleimani Farshid , Gholamipour Sara
Published: July 2023

Marine protected areas (MPAs) are one of the policy tools to support marine biodiversity conservation and sustainable use of marine resources. The distribution, sources, and ecological risk assessment of persistent organic pollutants (POPs), including polycyclic aromatic hydrocarbon (PAHs), total petroleum hydrocarbons (TPHs), polychlorinated biphenyls (PCBs), trace metals, and metalloids in sediments of MPAs in the northern Persian Gulf were evaluated for the first time in this study. The Σ16PAHs ranged from 4.65 to 20.86 µg/kg dw. The molecular ratios and ring's pattern of PAHs suggested a mixed origin with a predominance of pyrogenic sources. The TPHs concentration varied from 5.21 to 17.90 µg/g dw. Ecological risk assessment suggested that sediment samples in Bushehr Province’s MPAs can be categorized as medium risk. The mean concentration of ∑18PCB was 0.345–0.419 ng/g dw, and the main components correspond to PCB-77, PCB-105, PCB-81, PCB-101, and PCB-114. The mean concentration of As, Co, Cr, Ni, V, Mg, Pb, Zn, Cu, Al, and Fe varied from 4.79–9.69, 2–12, 39–142, 18–90, 15–58, 184–425, 7-459, 6-424, 4–20 µg/g dw, 0.75–4.12%, and 0.35–1.62%, respectively. The results of this study provided the background information on the extent of POPs contamination in the sediment and highlighted the need to further control pollution in MPAs.
Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework
Authors: Fois Matteo , Diaz-Artiles Ana , Zaman Syeda Yasmin , Ridolfi Luca , Scarsoglio Stefania
Published: July 2023

Head-down tilt (HDT) has been widely proposed as terrestrial analogue of microgravity and used also to investigate the occurrence of the spaceflight associated neuro-ocular syndrome (SANS), which is currently considered one of the major health risks for human spaceflight. We propose here a novel, in vivo validated numerical framework to simulate the acute ocular-cerebrovascular response to 6° HDT and to explore the etiology and pathophysiology of SANS.
The model links cerebral and ocular posture-induced hemodynamics, simulating the response of the main cerebrovascular mechanisms, as well as the relationship between intracranial and intraocular pressure to HDT. Our results from short-term (10 min) 6° HDT show increased hemodynamic pulsatility in the proximal-to-distal/capillary-venous cerebral direction, a marked decrease (-43%) in ocular translaminar pressure, and an increase (+31%) in ocular perfusion pressure, suggesting a plausible explanation of the underlying mechanisms at the onset of ocular globe deformation and edema formation over longer time scales.
Association Between Needle Track Bleeding and Postoperative Immediate Pneumothorax in CT-Guided Percutaneous Transthoracic Lung Biopsies: A Cross-Sectional Study
Authors: Zhou Shao-Quan , Luo Fang , Li Kang , Ran Xiong , Lv Fu-Rong
Published: July 2023

Background:
The relationship between Needle Track Bleeding (NTB) and the occurrence of postoperative immediate pneumothorax remains unclear.
Methods:
In our cross-sectional study, we conducted a retrospective collected of data from 674 consecutive patients who underwent CT-guided percutaneous transthoracic lung biopsies between 2019 and 2022. A logistic regression model was employed to explore the association between NTB and postoperative immediate pneumothorax, and restricted cubic spline curves was used to investigate the link and its explicit curve shape. A sensitivity analysis was performed by transforming the continuous NTB into categorical variable and calculated an E-value.
Results:
A total of 453 participants (47.90% male) were included in our analysis. The postoperative immediate pneumothorax rate was 41.05% (186/453). We found a negative correlation between NTB and postoperative immediate pneumothorax (OR = 0.91, 95%CI: 0.88–0.95) after adjusting for confounding factors. This relationship was nonlinear, with a key inflection point at NTB of 8mm. No significant link was noted for NTB > 8mm (OR = 0.98, 95%CI: 0.95–1.02), while a protective association was observed for NTB ≤ 8mm (OR = 0.74, 95%CI: 0.66–0.81).
Conclusion:
NTB showed a nonlinear, protective correlation with postoperative immediate pneumothorax. However, when NTB exceeded 8mm, the protective association was not observed.
The impact of histologic subtype on primary site surgery in the management of metastatic lobular versus ductal breast cancer: a population based study from the National Cancer Database
Authors: Rothschild Harriet T , Clelland Elle N , Abel Mary Kathryn , Chien A Jo , Shui Amy M , Esserman Laura , Khan Seema A , Mukhtar Rita A
Published: July 2023

Purpose
Primary site surgery for metastatic breast cancer improves local control but does not impact overall survival. Whether histologic subtype influences patient selection for surgery is unknown. Given differences in surgical management between early-stage lobular versus ductal disease, we evaluated the impact of histology on primary site surgery in patients with metastatic breast cancer.
Methods
The National Cancer Database (NCDB, 2010–2016) was queried for patients with stage IV HR-positive, HER2-negative invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC). We compared clinicopathologic features, primary site surgery rates, and outcomes by histologic subtype. Multivariable Cox proportional hazard models with and without propensity score matching were used for overall survival (OS) analyses.
Results
In 25,294 patients, primary site surgery was slightly but significantly less common in the 6,123 patients with ILC compared to the 19,171 patients with IDC (26.9% versus 28.8%, p = 0.004). Those with ILC were less likely to receive chemotherapy (41.3% versus 47.4%, p < 0.0001) or radiotherapy (29.1% versus 37.9%, p < 0.0001), and had shorter OS. While mastectomy rates were similar, those with ILC had more positive margins (10.6% versus 8.3%, p = 0.005). In both groups, the odds of undergoing surgery decreased over time, and were higher in younger patients with T2/T3 tumors and higher nodal burden.
Conclusion
Lobular histology is associated with less primary site surgery, higher positive margin rates, less radiotherapy and chemotherapy, and shorter OS compared to those with HR-positive HER2-negative IDC. These findings support the need for ILC-specific data and treatment approaches in the setting of metastatic disease.
Common causes of maternal mortality based on ICD-MM: A systematic review and meta- analysis
Authors: Alipour Jahanpour , Payandeh Abolfazl , Karimi Afsaneh
Published: July 2023

Background
Maternal mortality is a universal public health challenge. The present study was conducted to estimate the global prevalence of maternal death causes through a systematic review and meta-analysis.
Methods
A systematic literature search was conducted using various databases, including Web of Science, PubMed, Scopus, ScienceDirect, Cochrane Library, as well as Persian databases such as MagIran and SID. The search encompassed articles published until August 21, 2022. Thirty-four eligible articles were included in the final analysis. Analysis was performed using a meta-analysis approach. The exact Clopper-Pearson confidence intervals, heterogeneity assessment, and random effects models with Mantel-Haenszel methods were employed using the STATA software version 14.2.
Results
The most prevalent causes of maternal deaths, listed in descending order from highest to lowest prevalence, were non-obstetric complications (48.32%), obstetric hemorrhage (17.63%), hypertensive disorders of pregnancy, childbirth, and the puerperium (14.01%), other obstetric complications (7.11%), pregnancy with abortive outcome (5.41%), pregnancy-related infection (5.26%), unanticipated complications of management (2.25%), unknown/undetermined causes (2.01%), and coincidental causes (1.59%), respectively.
Conclusion
Accurate and timely diagnosis and treatment of conditions complicating pregnancy, childbirth, and the puerperium continue to pose a significant gap in high-quality care for pregnant women worldwide, particularly in developing countries where the incidence is higher. To reduce the burden of maternal mortality causes, it is crucial to implement effective screening mechanisms for high-risk mothers during pregnancy, childbirth, and the puerperium. Additionally, increasing awareness and promoting self-care management among women of reproductive age can play a significant role. Our findings offer comprehensive and standardized information on the prevalence of maternal mortality causes using the ICD-MM classification. This information can be utilized by policymakers and managers at various levels to facilitate necessary planning aimed at reducing the burden of maternal mortality causes.
Solenoid magnetic field simulation capability analysis based on current inversion
Authors: Lu Binjie , Zhang Xiaobin , Dai Zhonghua
Published: July 2023

In order to analyze the simulation capability of the solenoid to the ship's magnetic field, an equivalent magnetic dipole array model is used. Calculate the solenoid magnetic field. Based on the empirical setting of solenoid configuration parameters, combined with the measured data of the ship model magnetic field, the least squares method was used to invert the solenoid current based on the plane magnetic field vector inversion solenoid constant current, the planar magnetic field scalar inversion solenoid constant current, the planar magnetic field vector inversion solenoid time-varying current, and the planar magnetic field scalar inversion solenoid time-varying current and other four methods. The relative error of the solenoid magnetic field vector and scalar and the ship model magnetic field vector and scalar generated by the four inversion methods is calculated. The simulation capabilities of different inversion methods are compared and analyzed, and finally the current inversion method of solenoid simulating the ship's magnetic field is given.
Reading Diabetes Prevalence in India: Awareness vs. Affluence
Authors: Jena Abhinesh , Mishra Udaya Shankar , - Rinju
Published: July 2023

The literature is convincing on increasing affluence being a driver of rising prevalence of diabetes that is verified here in terms of associating an additional dimension of awareness. Given the doubling of prevalence of diabetes in India in a span of 5 years based on a comparison between NFHS-4 and NFHS-5, this is an attempt towards dis-entangling bearing of affluence/awareness on the rising trend of diabetes. Here we compute the characteristics odds and its conditional equivalent to understand the influence of the twin axis of awareness and affluence represented by education and wealth quintile. The awareness level odds of experiencing diabetes have widened more than the same owing to affluence as indicated by the gap in odds of the two across categories over time. Overall findings suggest despite the systematic role of affluence in shaping the disease prevalence, rising awareness serves as a key to its compression.
Positive and negative plant-plant interactions influence seedling establishment at both high and low elevations
Authors: Hischier Chantal M. , Lambers Janneke Hille Ris , Iseli Evelin , Alexander Jake M.
Published: July 2023

According to the stress gradient hypothesis (SGH), plant-plant interactions are expected to shift from predominantly negative (i.e. competition) to predominantly positive (i.e. facilitation) along gradients of environmental severity. The SGH has been particularly useful as a framework for understanding how plants interact with each other across elevation gradients, partly as a proxy for future responses to climate change. However, most experiments examine the net effects of interactions by growing plants in either the presence or absence of neighbours, thereby neglecting the interplay of both negative and positive effects acting simultaneously within communities. To partially unravel these effects, we tested how the seedling establishment of 10 montane grassland plants varied in the presence versus absence of plant communities at two sites along an elevation gradient. We created a third experimental treatment that retained the main hypothesised benefits of plant neighbours (microsite amelioration), while reducing a key negative effect (competition for soil resources). In contrast to predictions of the SGH, we found evidence for net positive effects of vegetation at the low site, and net negative effects at the high site. Interestingly, the surprisingly negative effects of plant neighbours at high elevation were driven by high establishment rates of low elevation grasses in bare soil plots. At both sites, establishment rates were highest in artificial vegetation (after excluding two low elevation grasses at the high site), indicating that positive effects of above-ground vegetation are partially offset by their negative effects. Our results demonstrate that both competition and facilitation act jointly to affect community structure across environmental gradients, while challenging the view that competition is weak at high elevation in temperate mountain regions. Consequently, plant-plant interactions are likely to influence the establishment of new, and persistence of resident, species in mountain plant communities as environments change.
Identification and characterization of CSE family members in cucumber reveals CsCSE5, a positive regulator of pathogen resistance
Authors: Yu Yong bo , He Jia jing , Liu Ling hao , Zhao Hong yan , Zhang Meng meng , Hong Jing hang , Meng Xiang nan , Fan Hai yan
Published: July 2023

Caffeoyl shikimate esterase (CSE), a key enzyme in the lignin biosynthetic pathway, has recently been characterized to play a key role in defense against pathogenic infection in plants. However, a systematic analysis of the CSE gene family in cucumber (Cucumis sativus) has not yet been conducted. Here, we identified eight CsCSEgenes from the cucumber genome via bioinformatic analyses, and these genes were unevenly distributed on chromosomes 1, 3, 4, and 5. Results from multiple sequence alignment indicated that the CsCSE proteins had CSE activity. Phylogenetic analysis of gene structure and protein motifs revealed the conservation and diversity of the CsCSE gene family. Collinearity analysis showed that CsCSEgenes had high homology with CSE genes in Benincasa hispida. Cis-acting element analysis of the promoters suggested that CsCSE genes might play important roles in growth, development, and stress tolerance. Expression pattern analysis indicated that CsCSE5 might be involved in regulating the resistance of cucumber to pathogens. Functional verification data confirmed that CsCSE5 positively regulates the resistance of cucumber to Podosphaera xanthii and Corynespora cassiicola. The results of our study provide information that will aid the genetic improvement of resistant cucumber varieties.
CD39 and LDHA affects the prognostic role of NLR in metastatic melanoma patients treated with immunotherapy
Authors: Mallardo Domenico , Fordellone Mario , White Andrew , Ottaviano Margaret , Sparano Francesca , Bailey Michael , Facchini Arianna , Ong Sufey , Maiolino Piera , Caracò Corrado , Church Sarah , Cavalcanti Ernesta , Warren Sarah , Budillon Alfredo , Cesano Alessandra , Simeone Ester , Chiodini Paolo , Ascierto Paolo A.
Published: July 2023

Background
Identifying response markers is highly needed to guide the treatment strategy in patients with metastatic melanoma.
Methods
A retrospective study was carried out in patients with unresectable/metastatic melanoma (stage IIIb–IV), treated with anti-PD-1 in the first line setting, to better explore the role and the timing of neutrophil/lymphocyte ratio (NLR) as potential biomarker of response. The relationship of NLR with inflammation-immune mediators and the underlying negative effect of raising NLR during immunotherapy, have been investigated with transcriptomic gene analysis.
Results
The results confirmed previous findings that a high baseline NLR is associated with a poorer prognosis and with higher serum level of lactate dehydrogenase (LDH), regardless of the presence of brain metastases. The transcriptomic analysis showed that high baseline NLR is associated with a characteristic gene signature CCNA1, LDHA and IL18R1, which is correlates with inflammation and tumorigenesis. Conversely, low baseline NLR is associated with the signature CD3, SH2D1A, ZAP70 and CD45RA, linked to the immune-activation. The genes positively associated with NLR (CD39 (ENTPD1), PTEN, MYD88, MMP9 and LDH) are involved in processes of immunosuppression, inflammation and tumor-promoting activity. Increased expression of CD39 correlated with TGFβ2, a marker of the N2 neutrophils with immunosuppressive activity.
Conclusions
These results suggest that increasing NLR is associated with an increased neutrophil population, with polarization to the N2 phenotype, and this process may be the basis for the negatively prognostic role of NLR.
Zeros of a One-parameter Family of Rational Harmonic Functions
Authors: Huang Yaru , Gao Junyang , Gao Linkui
Published: July 2023

This paper is devoted to investigating the number of zeros of a one-parameter familyof rational harmonic functions fc(z). It is considered to be as an analogue work on that of corresponding harmonic polynomials pc(z), which was investigated recently by Sandberg. Moreover, this paper explores the number of zeros of rational harmonic functions of rc(z). Our proofs rely on the Argument Principle for Harmonic Functions and the Poincare index.
Cutting tool wear prediction based on the multi-stage Wiener process
Authors: Wang Yuping , Chang Miaoxin , Huang Xianzhen , Li Yuxiong , Tang Jiwu
Published: July 2023

Cutting tools are one type of the critical components of the modern computer numerical control (CNC) machining system, whose failure can lead the whole system to fail or even cause substantive losses. Therefore, it is of great importance to study the method for tool wear prediction. A new model for wear prediction of cutting tools is established based on a multi-stage Wiener process, where the degradation rates of cutting tools are considered to change in three stages based on the typical cutting tool wear curve model. Firstly, the degradation processes of cutting tools are divided into three stages. Secondly, the parameter estimation for each stage of the degradation processes of cutting tools is completed respectively by utilizing the EM (expectation-maximization) algorithm. Then, the wear of cutting tools is predicted, and the reliability of cutting tools is analyzed by using a numerical integration simulation method based on the Monte Carlo algorithm. Finally, the proposed model is illustrated and verified via the flank wear data of cutting tools, and the prediction accuracy is measured by mean squared error (MSE) and the coefficient of determination (R^2). The prediction results show that the proposed model enables us to make more economical maintenance by delaying the tool replacement time with fewer degradation data. And compared to the traditional methods based on machine learning (ML), the proposed model can complete the wear prediction and reliability analysis more accurately.
Photospheric Velocities Measured at Mt. Wilson Show Zonal and Sectoral Flows Compose theTorsional Oscillations
Authors: Ulrich Roger K , Tran Tham , Boyden John
Published: July 2023

The methods for reducing the observations from the 150-foot Tower Telescope on Mt. Wilson are reviewed and a new method for determining the North/South (sectoral) and the East/West (zonal) velocity components is de-scribed and applied. Due to a calibration problem with the data prior to 1983, only observations between 1983 and 2013 are presented at this time. After sub-traction of latitude dependent averages over the 30-year period of observation the residual deviations in the sectoral and zonal flow velocities are well synchronized and correspond to what is widely recognized as the Torsional Oscillations. Both flow components need to be included in any model that replicates the Torsional Oscillations.
Dual antibody-aided mesoporous nanoreactor for H2O2 self-supplying chemodynamic therapy and checkpoint blockade immunotherapy in triple-negative breast cancer
Authors: Chen Ying-Tzu , Luo Ying-Xiang , Chan Shih-Hsuan , Chiu Wen-Yi , Yang Hung-Wei
Published: July 2023

Triple-negative breast cancer (TNBC) represents a formidable challenge due to the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, rendering it unresponsive to conventional hormonal and targeted therapies. This study introduces the development of mesoporous nanoreactors (NRs), specifically mPDA@CuO2 NRs, as acid-triggered agents capable of self-supplying H2O2 for chemodynamic therapy (CDT). To enhance therapeutic efficacy, these NRs were further modified with immune checkpoint antagonists, specifically anti-PD-L1 and anti-CD24 antibodies, resulting in the formation of dual antibody-aided mesoporous nanoreactors (dAbPD−L1/CD24-mPDA@CuO2 NRs). These NRs were designed to combine CDT and checkpoint blockade immunotherapy (CBIT) for precise targeting of 4T1 TNBC cells. Remarkably, dAbPD−L1/CD24-mPDA@CuO2 NRs exhibited tumor-targeted CDT triggered by H2O2 and successfully activated immune cells including T cells and macrophages. This integrated approach led to a remarkable inhibition of tumor growth by leveraging the collaborative effects of the therapies. The findings of this study introduce a novel and promising strategy for the integrative and collaborative treatment of refractory cancers, providing valuable insights into addressing the challenges posed by aggressive breast cancer, particularly TNBC.
Cross-Multilingual, Cross-Lingual and Monolingual Transfer Learning For Arabic Dialect Sentiment Classification
Authors: Boudad Naaima , Faizi Rdouan , Thami Rachid Oulad Haj
Published: July 2023

Transfer learning have recently proven to be very powerful in diverse Natural language processing (NLP) tasks such as Machine translation, Sentiment Analysis, Question/Answering. In this work, we investigate the use of transfer learning (TL) in Dialectal Arabic sentiment classification. Our main objective is to enhance the performance of Sentiment classification and overcome the low resource issue of Arabic dialect. To this end, we use Bidirectional Encoder Representation from Transformers (BERT) to transfer contextual knowledge learned from language modelling task to sentiment classification. We particularly use the multilingual models mBert and XLM-Roberta, the specific Arabic models ARABERT, MARBERT, QARIB, CAMEL and the specific Moroccan dialect Darijabert. After carrying out downstream fine-tuning experiments using different Moroccan SA datasets, we found that using TL significantly increase the performance of sentiment classification in Moroccan Arabic. Nevertheless, though specific Arabic models have proven to perform much better than multilingual and dialectal models, our experiments have demonstrated that multilingual models can be more effective in texts characterized by an extensive use of code-switching.