bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Economic Status of the Older Adults on the Satisfaction of Leisure Activities On Weekdays and Weekends
Authors:   The Korean Society of Culture and Convergence, Yeo Sodam , Han Changkeun
Published: February 2024

The study aims to examine the effect of economic status on leisure activity satisfaction on weekdays and weekends among older adults. This study used Data were drawn from the 8th wave of the Korean Retirement and Income Study(KReIS) Main(2019) and Additional Surveys (2020). The study sample is 3,955 older adults aged 65 years old and older. For analyses, frequency, descriptive, and logistic regression analyses. Key research findings are as follows, leisure activities that the elderly participate most on weekdays and weekends were “tv, radio, videos, music.” Satisfaction with leisure activities on weekdays and weekends was found to be unsatisfactory by one out of three people. Weekday leisure activities were dissatisfied with the higher the total asset level, and weekend leisure activities were satisfied with the higher the total asset level. Based on the research results, a practical and policy plan proposed to promote satisfaction of Leisure activities among older adults.
A Study of Anger Control from Buddhist Perspective
Authors:   The Korean Society of Culture and Convergence, Kim Mijin
Published: February 2024

The purpose of this paper is to find a way to control anger that becomes karma for a peaceful life of individuals rather than groups from the Buddhist perspective. This is not a sense of moral obligation, but an individual's free will which means loving oneself and liberating from oneself. Anger is a harmful mind. Anger belongs to anger among the three harmful minds from a Buddhist point of view. Anger is intended to be malicious. Malice stems from dissatisfaction. Therefore, the angry acts caused by the malice of dissatisfaction destroy both the life of an individual and the life of others. In a society that has to live in a group, the problem of anger is difficult to disappear in the past, present, and future. However, from a Buddhist point of view, I expect that if the suffering of anger is prevented and controlled in advance, I will be able to live an individual's peaceful life, which is the purpose of this paper. Therefore, in this study, we will first look at the mechanism of anger from a Buddhist perspective and then divide it into two ways to control it. The first is reflect on oneself from a preventive point of view, make a surrounding environment, and the other is to control it when anger occurs.
A Qualitative Research on Group Counseling Experience in Metaverse Space
Authors:   The Korean Society of Culture and Convergence, Seon Hyeyon , Chung Yeoju , Kim Yejee , Kim Huiju , Park Yerin , Lee Aesun
Published: February 2024

The purpose of this study is to provide basic data for counseling in the metaverse space by exploring the experiences of college students who have participated in metaverse group counseling. In this study, 36 students answered to a questionnaire asking group counseling experience in metaverse space, and the data were analyzed by a consensual qualitative research-modified(CQR-M). As a result, total 4 domains and 15 categories were drawn. 4 domains were ‘self within metaverse’, ‘metaverse space’, ‘content and goals of group counseling’, and ‘group counseling process’. Based on these results, implications for counseling in the metaverse space and suggestions for future research were discussed.
A Study on the Non-material Characteristics of ‘Counter Monument' and Its Case
Authors:   The Korean Society of Culture and Convergence, Koo Yoon ji , Yang Tae Keun
Published: February 2024

The purpose of this study is to understand monuments as an expanded form of participatory art projects aimed at healing collective trauma, based on James Young's concept of ‘Counter Monument’. Although the counter monument is a form that deviates from the material and sculptural framework of traditional monuments, it fulfills the original purpose of the monument, which is to ‘represent and preserve memories,’ and at this time, collective trauma brings about formal, media, and expressive changes in the monument. Accordingly, this study explains James Young's concept of counter monuments and the examples he indicates. Furthermore, it will analyze domestic cases that show collective trauma as non-material representations, focusing on interviews with the author and testimonies of participants. These ‘expanded monuments’ are a special way of mourning that seeks to ‘reinterpret within the meaning of the present’ the events that came as a big blow to the Korean society. At the same time, it has a very special meaning with 're-historicizing' those events within a new sense of cultural solidarity.
The Metaverse Zep-based English Language Learning for International Students: Focusing on Korean Cultural Content
Authors:   The Korean Society of Culture and Convergence, Lee Hyun-joo
Published: February 2024

The purpose of this study is to develop an English learning model for international students in Korea by implementing Korean cultural content in the metaverse. Since the majority of international students in Korea are from Asian countries, it is important to offer specialized courses for them. The English learning model consists of four modules for one semester, which use Korean cultural content to cover Korean gaming culture, Korean pop music and dance, Korean society and cultural heritage, and Korean traditional instruments and costumes. In addition, the Metaverse ZEP encourages student participation and academic achievement through various activities such as games, discussions, and presentations. Popular Korean cultural content, which is most preferred by international students, is used in the learning model to improve their English language skills and to learn about Korean culture. The study will provide new insights for developing customized English courses for international students.
A Comparative Study between Korea and Japan on the Status of After-School Child Education and Support Services for Children's Education
Authors:   The Korean Society of Culture and Convergence, Quan Ronghuan , Cha Myonghee , Lee Miyoung
Published: February 2024

This study compares after-school children's education in Korea and Japan. The comparison is the current status, service, and practice case of after-school child education. The purpose of the study is to find implications for after-school child education in Korea through comparison between Korea and Japan, not only for the safety of children, but also for the well-being and quality of life of the family surrounding children. As for the research method, afterschool child education in the two countries was explored through a comparative research method between countries. As a result of the study, Korea had problems with service quality and stigma. Japan has a long history of after-school education, so it is now providing services to children with disabilities and multicultural children. In addition, Japan was an education that put emphasis on social relationship formation. The significance of this paper is that it proposed after-school education services necessary for Korea through comparison of afterschool children's education and presented a future vision for after-school children's education.
Death Due to Furosemide Anaphylaxis and The Importance of Serum Tryptase Level in Diagnosing Anaphylaxis: A Case Report
Authors: Dağlı Soner , Şener Mustafa Talip , Kök Ahmet Nezih , Şahpaz Ahmet
Published: February 2024

Anaphylaxis is a severe systemic hypersensitivity reaction with a sudden onset and may result in death. In this study, we report the case of a 71-year-old female patient who died within seconds after the administration of intravenous furosemide in emergency service; she had high serum tryptase levels at postmortem examination and nonspecific findings at autopsy, and death due to anaphylaxis was reported. With this study, we wanted to point to the rare and potentially fatal drug anaphylaxis, such as furosemide anaphylaxis. Also, our results indicate the importance of serum tryptase levels in the diagnosis of death due to anaphylaxis.
PESAN DAKWAH DALAM PODCAST YOUTUBE KOPIPANAS.CHANNELS EDISI #2 CAFEKITA – ULAS BUKU-CINTANYA HATI SUHITA
Authors: Husnul Inayah Hasna , Slamet Moh.
Published: February 2024

In this advanced and modern era, the activities of Islamic preaching (dakwah) have adapted to the current developments, particularly through the sophistication of social media. This study examines the preaching messages found in the YouTube Podcast titled "Kopipanas.channels Edisi #2 Cafekita - Ulas Buku-Cintanya Hati Suhita 14 November 2021". A Qualitative Descriptive Approach using the Holsti Content Analysis method is employed to address this issue. Primary data is gathered from YouTube Social Media, without the necessity of statistical data, but rather through the analysis of sentences and excerpts of the conveyed messages. The study categorizes the preaching messages into three main categories: creed (akidah), Islamic law (syari'at), and morality (akhlak), which constitute the core teachings of Islam. Through this approach and method, the study aims to describe these messages.
A ABORDAGEM SOMÁTICA DO MOVIMENTO COMO ESTRATÉGIA DE PREPARAÇÃO CORPORAL: BREVE ANÁLISE DE PRÁTICAS CORPORAIS EM UMA MONTAGEM TEATRAL REALIZADA EM CONTEXTO ACADÊMICO
Authors: Pedrotti Amanda , Berselli Marcia
Published: February 2024

A partir de questionamentos sobre o corpo na sociedade contemporânea e nas linguagens artí­sticas, o artigo busca reconhecer como respeitar as singularidades corporais de alunos de um curso de teatro em ní­vel superior durante o desenvolvimento de uma montagem teatral. São analisadas as práticas desenvolvidas no contexto de preparação corporal na criação do acontecimento cênico "Antes de falar já não se ouve" vinculado a disciplinas curriculares, que teve como abordagem de criação o Processo Colaborativo (Araújo, 2009), possibilitando um conhecimento maior sobre os elementos que compõem a cena, para além da atuação e da encenação. Através do reconhecimento da idealização de corpo vivenciada atualmente, foi possí­vel observar que isso também se destaca no campo das Artes Cênicas. Foi investigada e pesquisada a função de preparadora corporal, que teve como metodologia a Educação Somática (Bolsanello, 2005; 2010; 2012), auxiliando os alunos a tomarem consciência do seu próprio corpo e reconhecendo seus movimentos, tendo como ênfase não o que se aprende, mas como se aprende.
CONSTRUÇÕES, DELINEAMENTOS E DIÁLOGOS ENTRE O CORPO NA DANÇA E NAS ARTES VISUAIS
Authors: Schreiber Monica
Published: February 2024

RESUMO: Esta investigação qualitativa com abordagem metodológica de revisão bibliográfica reflete sobre a relação dialógica entre o corpo dançante e a artes visuais, problematizando a linguagem hí­brida da performance. Em um primeiro momento, procura-se elucidar os conceitos e representações dos corpos nos contextos históricos das artes visuais e da dança, admitindo-se que o corpo foi desconstruindo formalizações e comportando novos espaços artí­sticos a partir do século XX. O artigo focaliza o corpo dançante hí­brido atuando como sujeito e como objeto artí­stico, no âmbito da performance, elencando, para tal intento, diferentes artistas que investigam esse corpo em suas possibilidades expressivas. O espaço de construção da performance abarca múltiplas possibilidades artí­sticas, pois permite o envolvimento de diferentes linguagens e corpos. Ao adentrar nas questões e conceitos da performance e da dança percebe-se que a comunicação entre as linguagens sempre esteve presente na história da arte e ainda, a imanência dos sujeitos em relação as profusões no ato de criar.PALAVRAS-CHAVE: Linguagem; Corpo; Performance; Artes visuais; Dança.
CORPO CÍTRICO – SINESTESIA E ENAÇÃO EM DANÇA
Authors: Pimenta Beatriz Malaquias
Published: February 2024

Este memorial tem como objetivo descrever o processo de criação do trabalho artí­stico-acadêmico "Corpo Cí­trico" , apresentado como requisito parcial para a conclusão do Curso de Bacharelado e Licenciatura em Dança da UNESPAR/Faculdade de Artes do Paraná. A questão em estudo, assim como os procedimentos de criação apresentados, dialogam com o conceito de percepção sob o ponto de vista neurocientí­fico cognitivo, enfatizando a não dissociação entre razão e emoção conforme proposto pelo médico neurologista António Damásio e o conceito de enação, na concepção do biólogo e filósofo Francisco Varella, entendido como um modo de apreensão do mundo que se dá no corpo em movimento. Os procedimentos adotados procuraram potencializar a ideia de percepção-ação na exploração do fenômeno da sinestesia, isto é, no entrecruzamento dos sentidos orgânicos e suas interfaces sensório-motoras, investigando modos de percepção enativa entre o contato do corpo com a fruta cí­trica limão e a organização de discursos corporais em cena.PALAVRAS-CHAVE: Corpo; Dança; Enação; Percepção; Sinestesia.
A EXPERIÊNCIA DA DANÇA COMO CONVITE À EMANCIPAÇÃO: VIVÊNCIAS NO PROCESSO DE FORMAÇÃO DO PROFESSOR ARTISTA
Authors: Lima Pablo Vinícius de
Published: February 2024

Esta pesquisa configura-se como um artigo pautado nas experiências vividasdurante o Estágio Supervisionado Obrigatório do oitavo perí­odo do Curso de Bacharelado eLicenciatura em Dança da Universidade Estadual do Paraná, na tentativa de experimentara Dança como ação emancipatória e então refletir sobre possibilidades de promover outrosmodos de ser e estar como estudante, artista e futuro professor, buscando borrar fronteirasentre o espaço de aula e o fazer artí­stico. Esta escrita se tece na tensão entre perceberas brechas e negociar acordos entre a Dança e a Escola Pública na cidade de Curitiba,no Brasil de 2018. Assim, a atenção como artista e professor em constante processo deaprender e arriscar e o desejo de deslocar os modos de percepção de si e do outro e delógicas condicionadas no trato com o aprender, são impulsionadores à continuidade destapesquisa que se fez nutrida da experiência no Estágio Supervisionado.
BALLET CLÁSSICO NA EDUCAÇÃO INFANTIL: DIÁLOGOS ENTRE BAKHTIN E A SOCIOLOGIA DA INFÂNCIA
Authors: Castilho Thaís
Published: February 2024

O presente artigo promove o diálogo entre os postulados de Bakhtin e o Cí­rculoe a Sociologia da Infância, a fim de problematizar o ensino de Ballet Clássico no contextoda Educação Infantil. Como resultados, a partir da ideia de enunciado-dançado, verifica-seque os movimentos das crianças correspondem a enunciados corporais e corroboram aimportância da dança na esfera escolar. Ao desenvolverem uma compreensão dialógica sobreo Ballet, as crianças produzem sentidos sobre essa Arte, construindo (auto)conhecimentos.Estima-se que, por meio da reprodução interpretativa, imbricada aos compartilhamentoscom seus pares, os pequenos transportem o Ballet para o universo das culturas infantis,realizando os passos clássicos num estado de coautoria, na condição de a(u)tores sociais.
ВОСПРИЯТИЕ «ЗДОРОВОГО ПИТАНИЯ» В ПОСТКОВИДНОЙ РЕАЛЬНОСТИ
Authors: Полтавец Ю.И.
Published: February 2024

Коронавирусная инфекция внесла значительные изменения в образ жизни человеческой цивилизации. Повсеместно вводимые ограничительные мероприятия и информационные кампании для противодействия биологической угрозе стали факторами, влияющими на отношение людей к здоровью. Наиболее простым способом оздоровления является оздоровление через питание – прием «здоровой пищи».

Рассматривая сложившуюся ситуацию как глобальный социальный эксперимент, признаками которого она обладает, было проведено изучение отношения к «здоровому питанию» как с использованием литературных данных, так и путем непосредственного изучения вопроса с помощью интервьюирования и анкетирования.

Полученные результаты показали наличие ранее не описанного явления – глобальной «традиции» употребления в пищу определенных видов пищевых продуктов. Общественные мероприятия, посвященные «здоровому питанию», служат местами обмена информации и формирования наблюдаемого явления.

Опрос респондентов в условиях постковидной реальности продемонстрировал их высокий уровень информированности в области «здорового питания». В то же время, существует запрос на сакральную «здоровую» пищу, обладающую целительными свойствами.
СУИЦИД И ОБЩЕСТВЕННАЯ КУЛЬТУРА В БРЕТАНИ
Authors: Ронан Ле Коадик
Published: February 2024

В чем причина того, что на протяжении ХХ в. уровень суицидов в Бретани из самого низкого во Франции стал самым высоким? На этот вопрос невозможно дать однозначный ответ, поскольку сам феномен суицида является сложным. Возможно предположить, однако, что пережитые за это время резкие социокультурные потрясения, разрушившие и изменившие общественную культуру на полуострове, тем самым сделали уязвимым его население и способствовали его саморазрушительному поведению.
К ОПРЕДЕЛЕНИЮ ФЕНОМЕНА НАРКОТИКА (ФРАГМЕНТ ИНТЕРВЬЮ)
Authors: Феликс Гваттари
Published: February 2024

Во фрагменте интервью психоаналитик Феликс Гваттари, отвечая на вопрос о зависимостях, предлагает взглянуть на наркотики не с биологической, а с социальной точки зрения и, таким образом, выделяет в качестве фундаментальных элементов наркотической или поведенческой зависимости повторение (ритм) и темпоральность. Гваттари предполагает, что 1) «наркотик» — это способ отрезать себя от определенного типа отношений со временем и от определенного типа отношений с другим; 2) наркотики имеют отношение к определенному способу артикуляции времени, который можно назвать семиотизацией времени. Иными словами, это нечто, имеющее тенденцию к уплотнению, к созданию для себя субъективной территории на основе ритма, на основе отношений с пространством, которое составляет своего рода защиту, развивает частную, замкнутую систему референции.
The effects of different iron shaft weights on golf swing performance
Authors: Yang Chia-Chen , Chang Che-Chia , Chao Te , Tai Hsia-Ling , Tsai Yung-Shen
Published: February 2024

This study examined the effects of three 7-iron shaft weights on golf swing performance among golfers of varying skill levels. The study included 10 low-handicap (LH; 4.3 ± 2.4) and 10 high-handicap (HH; 29.1 ± 5.4) right-handed golfers as participants. The participants were randomly assigned 7-iron clubs with shaft weights categorized as light (77 g), medium (98 g), or heavy (114 g), and they performed test shots. Kinematic data were captured using a motion analysis system with nine infra-red high speed cameras; a force platform connected to this system was used to record weight transfer patterns. Performance variables were assessed using a FlightScope launch monitor. A two-way mixed-design analysis of variance was used to determine the significance of the performance differences among both participant groups and golf shaft weights. The results indicated that during the backswing, the LH group exhibited significantly greater maximum rightward upper torso rotation, maximum X-factor, and maximum right wrist hinge rotation than did the HH group. During the downswing, the LH group exhibited significantly greater maximum upper torso angular velocity and maximum right wrist angular velocity than did the HH group. Moreover, the LH group produced significantly higher ball speeds, longer shot distances, and lower launch angles than did the HH group. The shaft weight neither greatly altered the golf swing nor displaced the center of gravity of the golfers. The lighter shafts were observed to facilitate faster clubhead speeds and initial ball velocities, thereby resulting in longer shot distances, especially among LH golfers. Although significant differences in swing mechanics and performance exist between HH and LH golfers, lighter shafts can contribute to increased shot distances for all golfers.
Amine-containing yolk-shell structured magnetic organosilica nanocomposite as a highly efficient catalyst for the Knoevenagel reaction
Authors: Neysi Maryam , Elhamifar Dawood
Published: February 2024

The yolk-shell structured silica nanocomposites have been considered by many researchers due to their specific physical and chemical properties. These materials have been widely used in adsorption and catalysis processes. Especially, the void space of yolk−shell nanostructures can provide a unique environment for storage, compartmentation, and confinement in host−guest interactions. In this paper, for the first time, the preparation, characterization, and catalytic application of a novel amine-containing magnetic methylene-based periodic mesoporous organosilica with yolk-shell structure (YS-MPMO/pr-NH2) are developed. The magnetic periodic mesoporous organosilica nanocomposite was synthesized through surfactant-directed co-condensation of bis(triethoxysilyl)methane (BTEM) and tetraethoxysilane around Fe3O4 nanoparticles. After Soxhlet extraction, the surface of YS-MPMO nanocomposite was modified with 3-aminopropyl trimethoxysilane to deliver YS-MPMO-pr-NH2 nanocatalyst. This catalyst was characterized by using EDX, FT-IR, VSM, TGA, XRD, nitrogen-sorption, and SEM analyses. The catalytic activity of YS-MPMO/pr-NH2 was studied in the Knoevenagel reaction giving the corresponding products in a high yield and selectivity. The YS-MPMO/pr-NH2 nanocatalyst was recovered and reused at least four times without a significant decrease in efficiency and activity. A leaching test was performed to study the nature of the catalyst during reaction conditions Also, the catalytic performance of our designed nanocomposite was compared with some of the previous catalysts used in the Knoevenagel reaction.
Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001–2018
Authors: Yin Yufeng , Zhou Erye , Wu Jian
Published: February 2024

Objective

The prevalence of hyperuricemia and hypertension is steadily increasing, and these conditions often share common risk factors. This study aimed to investigate the association among hyperuricemia, hypertension, and all-cause mortality in a nationally representative U.S. population.

Methods

Data for 38,644 participants were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001–2018. Hyperuricemia was defined as a serum urate concentration >420 μmol/L in men and >360 μmol/L in women. Information regarding death outcomes was obtained through the National Death Index (NDI). Multivariate logistic regression, Cox proportional hazards models, and restricted cubic spline (RCS) analyses were used to evaluate the association between hyperuricemia and hypertension in all included participants, as well as long-term mortality in patients with hypertension.

Results

Among all participants, 6,956 (18.0%) had hyperuricemia, while 31,688 (82.0%) had nonhyperuricemia. According to the adjusted models, hyperuricemia was more strongly associated with hypertension (OR 2.04) than was non-hyperuricemia. During the median follow-up period of 78 months, both hyperuricemia (HR 1.48, 1.95) and hypertension (HR 1.42, 1.69) independently associated with the increased risk of all-cause mortality and cardiovascular mortality, respectively, with the highest risk observed in those with both conditions (HR 1.87, 2.82). RCS analyses revealed nonlinear J-shaped (for hypertension) and U-shaped (for both all-cause and cardiovascular mortality) relationships with serum urate levels.

Conclusions

Hyperuricemia is associated with an elevated risk of developing hypertension compared to non-hyperuricemia. Among patients with hypertension, those with hyperuricemia are more likely to experience all-cause and cardiovascular mortality during long-term follow-up.
Case Report: Kounis syndrome due to cryptopteran bite
Authors: Liao Rui , Cheng Shengjie , Xu Nan
Published: February 2024

Background

Kounis syndrome is an acute coronary syndrome (ACS) caused by allergic reactions, including coronary artery spasm (type I) caused by allergies without coronary predisposing factors, pre-existing coronary atherosclerosis, and coronary artery disease. Anaphylaxis leads to plaque rupture or erosion leading to acute myocardial infarction (type II) and acute coronary stent thrombosis (type III). Here we share a case of Kounis syndrome type I caused by an allergy caused by a Cryptopteran bite.

Case presentation

A 47-year-old woman was admitted to the hospital due to an insect bite for 2 days and chest distress for more than 3 h. Outside the hospital, electrocardiogram(ECG) showed sinus rhythm, ST-segment elevation in leads V1–V3, high-sensitivity troponin 2.54 ng/ml(0–0.5 ng/ml). One hour later, the ECG of the patient showed that the ST segment elevation of lead V1–V4 was 0.10–0.20 mV. Emergency coronary angiography showed coronary spasm and moderate lumen stenosis in the middle segment of left anterior descending artery (LAD). After treatment, the patient's symptoms were relieved, and the ST segment of lead V1–V4 of electrocardiogram returned to normal.

Conclusion

Kunis syndrome is a life-threatening condition that can also cause myocardial ischemic injury in patients with or without coronary artery disease. Timely identification and anti-allergic treatment can achieve a good prognosis.
Diagenetic alterations and deep high-quality reservoirs within deltaic distributary channel facies: a case study from the Permian Shihezi formation in the Hongde area, southwestern Ordos basin, China
Authors: Wu Xiaoming , Shen Zhicheng , Bao Yanxin , Wang Weilin , Yan Zhandong , Wang Bo , Zheng Xiaoyin , Dou Luxing , Wen Zhigang
Published: February 2024

Deep tight gas reservoirs are considered important hydrocarbon exploration targets. High-quality reservoir prediction is critical for successfully exploring and developing deeply buried tight sandstone gas. Previous research has found that the reservoir quality of deeply buried tight sandstones is controlled by diagenesis and sedimentary facies. However, the variation of diagenetic alterations in different facies is still poorly studied on deltaic tight gas sandstone. In this study, core analysis, wireline log data, and 3D seismic were studied for the characterization of diagenetic alterations and sedimentary facies. The tight sandstones were formed in braided river delta deposits. Gravel-bearing coarse-grained sandstone facies and cross-bedded sandstone facies developed in tight sandstones. The Gravel-bearing coarse-grained sandstone is formed in the mid-channel bar of deltaic distributary channels. The major diagenetic processes developed in the tight sandstone include compaction, cementation, and dissolution. Constructive diagenesis can generate secondary pores, mainly including dissolution and kaolinite metasomatism, which can effectively improve reservoir physical properties. Through the diagenesis alterations linked to different lithofacies in cored wells, there are obvious diagenesis variations in different lithofacies. Despite strong compaction, the reservoirs in coarse sandstone facies have developed internal dissolution. After compaction, cementation, and dissolution to increase porosity, the reservoir retains intergranular and secondary pores and forms relatively high-quality reservoirs. The fine sandstone facies with cross-bedding are strongly compacted, with internal ductile particles being compacted and deformed, and the particle orientation is clearly arranged. The reservoir is tight, and the development of dissolution in the reservoir is weak, resulting in poor reservoir quality. In addition, reservoirs located at the interface between sandstone and mudstone are often affected by diagenesis, resulting in the development of calcareous cementation, leading to poor reservoir quality. Therefore, high-quality reservoirs are mostly distributed in coarse sand lithofacies, mainly distributed in the mid-channel bar of distributary channel deposits. Sedimentary facies control the original physical properties of the reservoir with different content and texture; the quality of the original reservoir is subject to diagenetic alteration in different ways. The points in this study could offer insights better to predict deep tight reservoir quality in continental basins.
Calculation of the available transfer capability of trading channels based on power network congestion forecasting
Authors: Wei Congying , Jia Longwen , Wang Xiongwei , Cai Yu , Huang Ying , Huang Yanbo , Liao Siyang
Published: February 2024

Against the backdrop of increasing renewable energy penetration, frequent power network congestion has become a key issue limiting the available transfer capability of trading channels. In order to avoid power network congestion while improving the overall utilization of trading channels, we propose a method for calculating the available transfer capability of a trading channel based on power network congestion forecasting. First, this study uses a histogram-based gradient tree boosting (HGTB) model to forecast the severity and probability of power network congestion, which enables power system operators to determine the specific circumstances of congestion occurrence. Second, we analyze the sensitivity of the power trading network and generating units to transmission lines, aiming to calculate the available transfer capability of the trading channel on the basis of taking into account the control of transmission line congestion and the balance of supply and demand in the power market. Finally, the validity of the validation methodology is verified based on a case study of the power system in central China.
Which energy labels should we use to expedite the transition to electric vehicles?
Authors: Scarlat Gal , Rosenzweig Stav , Rubin Ofir
Published: February 2024

In recent years, numerous countries have enacted legislation to halt fossil-fueled vehicle sales within five to 10 years. With shrinking global markets for these vehicles, manufacturers are increasingly motivated to redirect them towards nations with less stringent regulations, using attractive prices and other tactics. However, the sale of new fossil-fueled vehicles poses a public challenge as they will remain in use for years. Consequently, reducing the likelihood of consumers purchasing new fossil-fueled vehicles in favor of electric vehicles is crucial in all countries, particularly those with less stringent regulations, to meet emission goals. Efforts to promote electric vehicle adoption through policy measures fall short due to underestimated cognitive biases and consumer behavior impacts. We contribute to the literature by bridging the gap between human behavioral studies and environmental policy. We incorporate choice architecture into energy labels to determine which information architecture regarding energy costs is an effective nudge in increasing electric vehicle purchase intentions. Our experiment finds that labels framing energy costs as ‘expenditure,’ rather than ‘savings,’ are more effective in increasing the intent to purchase an electric vehicle. Additionally, we find that a graphical display of expenditure was not effective in influencing purchase intentions. Policymakers can use similar choice architecture tools to encourage electric vehicle adoption, expediting the transition to electric vehicles and achieving national environmental goals.
sscNOVA: a semi-supervised convolutional neural network for predicting functional regulatory variants in autoimmune diseases
Authors: Li Haibo , Yu Zhenhua , Du Fang , Song Lijuan , Gao Yang , Shi Fangyuan
Published: February 2024

Genome-wide association studies (GWAS) have identified thousands of variants in the human genome with autoimmune diseases. However, identifying functional regulatory variants associated with autoimmune diseases remains challenging, largely because of insufficient experimental validation data. We adopt the concept of semi-supervised learning by combining labeled and unlabeled data to develop a deep learning-based algorithm framework, sscNOVA, to predict functional regulatory variants in autoimmune diseases and analyze the functional characteristics of these regulatory variants. Compared to traditional supervised learning methods, our approach leverages more variants’ data to explore the relationship between functional regulatory variants and autoimmune diseases. Based on the experimentally curated testing dataset and evaluation metrics, we find that sscNOVA outperforms other state-of-the-art methods. Furthermore, we illustrate that sscNOVA can help to improve the prioritization of functional regulatory variants from lead single-nucleotide polymorphisms and the proxy variants in autoimmune GWAS data.
Relevance of histopathological findings for predictive scoring of short-term treatment response to plasma exchange in severe ANCA-associated renal vasculitides
Authors: Hakroush Samy , Korsten Peter , Ströbel Philipp , Tampe Björn
Published: February 2024

Introduction

Rapidly progressive glomerulonephritis (RPGN) is characterized by a rapid loss of kidney function, affecting both renal and overall patient survival. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis affecting multiple organ systems including the kidney, and among most frequent causes of RPGN. We here aimed to validate a recently described scoring system for short-term treatment response to therapeutic plasma exchange (PLEX) in a well-characterized and independent cohort of severe renal AAV presenting with RPGN. Furthermore, we compared this scoring with established classification systems in renal AAV including histopathological findings.

Methods

We here directly compare the scoring system with retrospective data about PLEX treatment in our own clinical practice and according to current recommendations in a cohort of 53 patients with severe AAV presenting with RPGN confirmed by kidney biopsy.

Results

We here confirm that PLEX scoring is capable to identify patients at risk for short-term poor outcome in severe AAV presenting with RPGN (p<0.0001). Furthermore, multiple stepwise regression analysis revealed that the PLEX score with renal biopsy performed best to predict poor outcome in this patient population (p<0.0001).

Conclusion

Our observations underscore the relevance of performing a kidney biopsy in this patient population that is often challenged in the setting of intensive care treatment, requirement of KRT with need for anticoagulation and bleeding risk. Therefore, validation of our observations and this recent scoring system for treatment response to PLEX in independent cohorts would be of great clinical relevance in the treatment of patients with severe AAV presenting with RPGN.
Comparison of the single-cell and single-nucleus hepatic myeloid landscape within decompensated cirrhosis patients
Authors: Van Melkebeke Lukas , Verbeek Jef , Bihary Dora , Boesch Markus , Boeckx Bram , Feio-Azevedo Rita , Smets Lena , Wallays Marie , Claus Eveline , Bonne Lawrence , Maleux Geert , Govaere Olivier , Korf Hannelie , Lambrechts Diether , van der Merwe Schalk
Published: February 2024

Background and aims

A complete understanding of disease pathophysiology in advanced liver disease is hampered by the challenges posed by clinical specimen collection. Notably, in these patients, a transjugular liver biopsy (TJB) is the only safe way to obtain liver tissue. However, it remains unclear whether successful sequencing of this extremely small and fragile tissue can be achieved for downstream characterization of the hepatic landscape.

Methods

Here we leveraged in-house available single-cell RNA-sequencing (scRNA-seq) and single-nucleus (snRNA-seq) technologies and accompanying tissue processing protocols and performed an in-patient comparison on TJB’s from decompensated cirrhosis patients (n = 3).

Results

We confirmed a high concordance between nuclear and whole cell transcriptomes and captured 31,410 single nuclei and 6,152 single cells, respectively. The two platforms revealed similar diversity since all 8 major cell types could be identified, albeit with different cellular proportions thereof. Most importantly, hepatocytes were most abundant in snRNA-seq, while lymphocyte frequencies were elevated in scRNA-seq. We next focused our attention on hepatic myeloid cells due to their key role in injury and repair during chronic liver disease. Comparison of their transcriptional signatures indicated that these were largely overlapping between the two platforms. However, the scRNA-seq platform failed to recover sufficient Kupffer cell numbers, and other monocytes/macrophages featured elevated expression of stress-related parameters.

Conclusion

Our results indicate that single-nucleus transcriptome sequencing provides an effective means to overcome complications associated with clinical specimen collection and could sufficiently profile all major hepatic cell types including all myeloid cell subsets.
Case report: Clinical complete response in advanced ALK-positive lung squamous cell carcinoma: a case study of successful anti-PD-1 immunotherapy post ALK-TKIs failure
Authors: Yang Chen , Zeng Rui , Zha Yawen , Li Yani , Wang Ting , Zhao Ruolan , Li Minying , Zhang Jingjing
Published: February 2024

In patients with advanced lung adenocarcinoma (LADC) harboring the echinoderm microtubule-associated protein-like 4 (EML4) -anaplastic lymphoma kinase (ALK) rearrangement, targeted therapy typically demonstrates superior efficacy as an initial treatment compared to chemotherapy. Following resistance to ALK-tyrosine kinase inhibitors (TKIs), regimens incorporating platinum-based dual agents or combined with bevacizumab often show effectiveness. However, therapeutic alternatives become constrained after resistance develops to both TKIs and platinum-based therapies. Given that the majority of ALK-positive non-small cell lung carcinomas (NSCLC) are LADC, the benefits of TKIs for patients with ALK-positive lung squamous cell carcinoma (LSCC) and the optimal treatment strategy for these patients remain a subject of debate. In this case study, we report on a patient with advanced LSCC, in whom the EML4-ALK rearrangement was identified via ARMS-PCR (Amplification Refractory Mutation System-Polymerase Chain Reaction). The patient underwent oral treatment with crizotinib and alectinib, showing effectiveness in both first-line and second-line ALK-TKI therapies, albeit with limited progression-free survival (PFS). Subsequent resistance to second-generation TKI was followed by the detection of tumors in the left neck region via computed tomography (CT). Biopsy pathology revealed non-squamous cell carcinoma, and subsequent treatment with platinum-based double-drug therapy proved ineffective. Further analysis through next-generation sequencing (NGS) indicated ALK negativity but a high expression of programmed death-ligand 1 (PD-L1). Immunotherapy was then initiated, resulting in a PFS of over 29 months and clinical complete remission (cCR). This case underscores the potential benefit of ALK-TKIs in patients with ALK-positive LSCC. Resistance to second-generation TKIs may lead to ALK negativity and histological transformation, highlighting the necessity of repeated biopsies post-TKI resistance for informed treatment decision-making. As of November 2023, imaging studies continue to indicate cCR in the patient, with a survival time exceeding 47 months.
The role of INFL in code-switching: a study of a Papiamento heritage community in the Netherlands
Authors: Parafita Couto M. Carmen , Pouw Charlotte , Laanen Rodi , López Luis
Published: February 2024

Introduction

In heritage bilingualism studies, code-switching has often been overlooked, with a focus on either the heritage language or the dominant societal language of the bilingual individual. However, exploring code-switching can provide valuable insights into heritage speakers' grammar, revealing patterns that may not be apparent when only examining monolingual speech. Recent research suggests that in code-switched clauses, functional elements must align with the language of verbal inflection (INFL), which encompasses tense, aspect, voice, and agreement. This generalization is usually referred to as the Matrix Language Frame (MLF). The present study explores the empirical validity of this generalization using an experimental protocol that controls for variables that earlier work did not take into consideration. These variables are (a) adjacency between INFL and the functional element, (b) the interaction of the MLF with embedded islands, and (c) the possibly degrading effects of inserting a functional category. Thus, the aim of this study is to provide evidence in support (or not) of the INFL constraint beyond the experimental limitations in earlier work. The study focuses on the bilingual combination Papiamento–Dutch. Our results, by and large, support the MLF generalization.

Methods

We carried out an online audio survey (3-point Likert scale) with 43 Papiamento–Dutch bilinguals. We manipulated the position of the switch and controlled for potential directionality effects by presenting code-switches in both switching directions.

Results

We find a scale of acceptability, where the conditions that respect the INFL constraint are preferred. Additionally, and consistent with recent corpus and experimental literature, our results point to a clear asymmetry regarding directionality effects or choice of ML, reflecting how code-switching is deployed in the community.

Discussion

Controlling for directionality allows us to discern the mechanisms of the INFL constraint. Thus, these findings underscore the intertwining influence of linguistic factors and community norms in guiding code-switching dynamics. Such insights extend beyond the specific context to shed light on broader dynamics within (heritage-language) bilingualism.
Characterization and toxicological potential of Alternaria alternata associated with post-harvest fruit rot of Prunus avium in China
Authors: Ahmad Tanvir , Xing Fuguo , Cao Changyu , Liu Yang
Published: February 2024

Post-harvest fruit rot caused by Alternaria species is one of the most important threats to the fruit industry. Post-harvest rot on sweet cherry (Prunus avium) fruit was observed in the fruit markets of the Haidian district of Beijing, China. The fungal isolates obtained from the infected sweet cherry fruits matched the descriptions of Alternaria alternata based on the morphology and multi-gene (ITS, endo-PG, and Alta1) sequence analysis. Pathogenicity tests indicated that ACT-3 was the most virulent isolate, exhibiting typical post-harvest fruit rot symptoms. Physiological studies revealed that the optimal conditions for the growth of ACT-3 were temperature of 28°C, water activity of 0.999, and pH of 8 with 87, 85, and 86 mm radial growth of ACT-3 on a potato dextrose agar (PDA) medium, respectively, at 12 days post-inoculation (dpi). Moreover, the fungus showed the highest growth on a Martin agar medium (MAM) modified (85 mm) and a PDA medium (84 mm) at 12 dpi. The proliferation of the fungus was visualized inside the fruit tissues by confocal and scanning electron microscope (SEM), revealing the invasion and destruction of fruit tissues. Alternaria mycotoxins, tenuazonic acid (TeA), and alternariol (AOH) were detected in five representative isolates by HPLC analysis. The highest concentrations of TeA (313 μg/mL) and AOH (8.9 μg/mL) were observed in ACT-6 and ACT-3 isolates, respectively. This study is the first to present a detailed report on the characteristics and proliferation of A. alternata associated with sweet cherry fruit rot and the detection of toxic metabolites.
Pseudomonas chlororaphis IRHB3 assemblies beneficial microbes and activates JA-mediated resistance to promote nutrient utilization and inhibit pathogen attack
Authors: Wei Dengqin , Zhu Dan , Zhang Yunfeng , Yang Zheng , Hu Yu , Song Chun , Yang Wenyu , Chang Xiaoli
Published: February 2024

Introduction

The rhizosphere microbiome is critical to plant health and resistance. PGPR are well known as plant-beneficial bacteria and generally regulate nutrient utilization as well as plant responses to environmental stimuli. In our previous work, one typical PGPR strain, Pseudomonas chlororaphis IRHB3, isolated from the soybean rhizosphere, had positive impacts on soil-borne disease suppression and growth promotion in the greenhouse, but its biocontrol mechanism and application in the field are not unclear.

Methods

In the current study, IRHB3 was introduced into field soil, and its effects on the local rhizosphere microbiome, disease resistance, and soybean growth were comprehensively analyzed through high-throughput sequencing and physiological and molecular methods.

Results and discussion

We found that IRHB3 significantly increased the richness of the bacterial community but not the structure of the soybean rhizosphere. Functional bacteria related to phosphorus solubilization and nitrogen fixation, such as Geobacter, Geomonas, Candidatus Solibacter, Occallatibacter, and Candidatus Koribacter, were recruited in rich abundance by IRHB3 to the soybean rhizosphere as compared to those without IRHB3. In addition, the IRHB3 supplement obviously maintained the homeostasis of the rhizosphere microbiome that was disturbed by F. oxysporum, resulting in a lower disease index of root rot when compared with F. oxysporum. Furthermore, JA-mediated induced resistance was rapidly activated by IRHB3 following PDF1.2 and LOX2 expression, and meanwhile, a set of nodulation genes, GmENOD40b, GmNIN-2b, and GmRIC1, were also considerably induced by IRHB3 to improve nitrogen fixation ability and promote soybean yield, even when plants were infected by F. oxysporum. Thus, IRHB3 tends to synergistically interact with local rhizosphere microbes to promote host growth and induce host resistance in the field.
Evolutionary dynamics and geographical dispersal of Borrelia lusitaniae
Authors: Cirkovic Valentina , Veinovic Gorana , Stankovic Daliborka , Mihaljica Darko , Sukara Ratko , Tomanovic Snezana
Published: February 2024

Background

Borrelia lusitaniae is a species within the complex Borrelia burgdorferi sensu lato, associated with lizards as reservoirs and Ixodes ricinus as its main vector. Borrelia lusitaniae is predominantly distributed in Central and Southeast Europe, and in countries of the Mediterranean basin, such as Portugal, Morocco, Tunisia, and Italy where this spirochete appears to infect vector ticks more frequently than other genospecies. Evolution of this zoonotic tick-borne microparasite is shaped by different environmental factors. Comprehensive phylogenetic analysis may give insight into how B. lusitaniae spreads to new geographic locations.

Aim

We applied Bayesian statistical methods to B. lusitaniae multilocus sequence typing (MLST) data to study the migration routes of B. lusitaniae and its potential for further spread.

Results

The discrete phylogeographic analysis placed origins of B. lusitaniae in Southeast Europe and identified at least two introductions of B. lusitaniae from Europe to North Africa. Estimated effective reproductive potential (Re), as a key indicator for a pathogen spread, suggested potential for further spread.

Conclusion

The results of this study can provide beneficial information about the potential for further spread of B. lusitaniae in Europe and North Africa and estimation of necessity for the development of strategies to monitor and control Lyme borreliosis.