bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH LATIHAN METODE DRILL DENGAN LATIHAN GAYA KOMANDO TERHADAP KETERAMPILAN SHOOTING SISWA EKSTRAKURIKULER FUTSAL SMP NEGERI 1 PLEMAHAN KABUPATEN KEDIRI
Authors: Ardiansyah Fino , Tomi Agus , Sugiarto Tatok
Published: November 2019

Abstract: The purpose of this research is to know the effect of drill method training to shooting skill of the student in SMPN 1 Plemahan Kediri. The research method that was used in this research was quasi experimental. The sample of this research was 30 students who were divided into two groups using ordinal pairing matching technique. The analysis technique that was used in research was one tailed of ANAVA. The research used F-test on significant level 0,05 to analyze the data, the researcher found three conclusions. 1) Drill method training have significantly effected to the students’ shooting skill in futsal extracurricular with FHitung 4,08<FTabel 4,20. 2) Practice of command style was significantly effected to the students’ shooting skill in futsal extracurricular with FHitung 0,56<FTabel 4,20. 3) There was a significantly different effect between the drill method training model and the command style method model with FHitung 2,42<FTabel 4,20. Keywords: training of drill method, training of command style, shooting skill of futsal. Abstrak: Tujuan dari penelitian ini adalah untuk mengetahui pengaruh latihan metode drill terhadap keterampilan shooting siswa ekstrakurikuler futsal SMP Negeri 1 Plemahan Kabupaten Kediri. Rancangan penelitian yang digunakan berupa penelitian eksperimen semu. Jumlah sampel yang digunakan 30 siswa dan dibagi dalam dua kelompok dengan teknik ordinal pairing matching. Teknik analisis yang digunakan adalah Analisis Varian (ANAVA) satu jalur. Berdasarkan hasil analisis data dengan menggunakan uji F pada taraf signifikansi 0,05, diperoleh tiga simpulan hasil penelitian. 1) Latihan metode drill memberikan pengaruh yang signifikan terhadap keterampilan shooting siswa ekstrakurikuler futsal dengan Fhitung 4,08<Ftabel 4,20. 2) Latihan gaya komando memberikan pengaruh yang signifikan terhadap keterampilan shooting siswa ekstrakurikuler futsal dengan Fhitung 0,56<Ftabel 4,20. 3) Ada perbedaan pengaruh yang signifikan antara model latihan metode drill dengan model latihan gaya komando dengan Fhitung 2,42<Ftabel 4,20. Kata kunci: latihan metode drill, latihan gaya komando, keterampilan shooting futsal.
PENGARUH MODEL LATIHAN TENDANGAN DOLLYO CHAGI MENGGUNAKAN ELASTIS POWER TERHADAP DAYA LEDAK OTOT TUNGKAI PADA OLAHRAGA TAEKWONDO DI UKM TAEKWONDO UNIVERSITAS NEGERI MALANG
Authors: Funay Nicky Anastasia , Wahyudi Usman , Amiq Fahrial
Published: November 2019

ABSTRACT: The objective of this research is to know the effect of dollyo chagi kick training using elastic power bands toward explosive power of leg muscle in Taekwondo martial art at UKM Taekwondo Universitas Negeri Malang. The result of the research which was obtained from male participants who have t-value of -8.113 with the significance of .000 and from female participants who have t-value of -6.786 with the same significance. The significance value (p-value) is smaller than the level of significance .05(p < α = 0.05), so H0 is rejected and Ha is accepted. In other words,  dollyo Chagi kick training program using elastic power bands can significantly increase the explosive power of leg muscle trainees of UKM Taekwondo Universitas Negeri Malang. Keywords: Dollyo Chagi, Training Model, Elastic Power Bands, Leg Muscle Explosive Power, Taekwondo ABSTRAK: Tujuan penelitian untuk mengetahui pengaruh latihan tendangan dollyo chagi menggunakan elastis power terhadap daya ledak otot tungkai pada olahraga Taekwondo di UKM Taekwondo Universitas Negeri Malang. Hasil penelitian yang dilakukan terhadap peserta latihan putra memperoleh nilai t-hitung sebesar -8,113 dengan nilai signifikansi sebesar 0,000 dan pada peserta latihan putri diperoleh t-hitung sebesar -6,786 dengan nilai signifikansi sebesar 0,000. Nilai signifikansi (p) lebih kecil dari taraf signifikansi 0,05 (p < α = 0,05), maka H0 ditolak dan Ha diterima. Program latihan tendangan dollyo chagi menggunakan elastis power  ini secara signifikansi dapat meningkatkan kemampuan daya ledak otot tungkai peserta latihan UKM Taekwondo Universitas Negeri Malang. Kata Kunci: , Dollyo Chagi, Model Latihan, Elastis Power, Daya Ledak Otot Tungkai, Taekwondo
Prevalence and determinants of obesity and overweight among college students of Gujarat, India: a cross sectional study
Authors: Panchal Saurabh Naranbhai , Agrawal Akash Virendrabhai , Thakor Nilesh
Published: November 2019

Background: Early adulthood obesity itself is a predictor of adult obesity and of higher than expected adult morbidity and mortality. The objective of this study was to know the prevalence and determinants of obesity in college students of Vadodara and Patan city of Gujarat, India.Methods: The present cross sectional study was undertaken during April 2017 to March 2018 in randomly selected 5 Colleges of Vadodara city and Patan City of Gujarat. Total 1330 students between the age group of 18 to 23 years were examined and BMI were calculated. The prevalence of overweight and obesity were determined based on the International Obesity Task Force criteria. Various determinants of obesity and overweight were studied by interviewing students. Thus collected data was analyzed using SPSS 17 (Trial version).Results: Out of 1330 students, males were 49.6% Prevalence of obesity and overweight was 6.1% and 11.0% respectively. The prevalence of obesity and overweight was higher amongst less active group (6.5% and 13.4% respectively). Prevalence of obesity and overweight was significantly higher in the group of students who spent >2 hours daily in front of television or computers. The prevalence of obesity and overweight was significantly higher amongst group of students who took daily calories above recommended dietary allowance (21.5% and 22.8% respectively). The prevalence of obesity and overweight was significantly higher who took junk food (9.3% and 14.8% respectively).Conclusions: High prevalence of obesity and overweight in college students indicate an urgent need to increase awareness via education and motivation of all stakeholders.
Cuerpo extraño alojado en el tercer ventrículo por arma neumática sin repercusiones neurológicas, a 12 años de seguimiento. Reporte de un caso
Authors: Barrón-Balderas Alejandro , Robledo-Aceves Mireya , López-Elizalde Ramiro , Barriga-Marín Javier Álvaro
Published: November 2019

ANTECEDENTES: Las lesiones por proyectil de arma neumática pueden ser mortales o con múltiples secuelas, principalmente si afectan el sistema nervioso central.CASO CLÍNICO: Paciente de 8 años, que sufrió un impacto de proyectil neumático (rifle de balines perdigón de 5.5 mm de calibre), a una distancia aproximada de 15 cm del rostro. No refirió pérdida del conocimiento, convulsiones ni vómito, solo dolor y sangrado abundante en el sitio de entrada del objeto. A su ingreso al hospital se encontraron constantes fisiológicas normales. En la región frontal se observó una herida circular, con bordes irregulares de 6 mm. Las radiografías de cráneo evidenciaron un cuerpo extraño radiopaco alojado en la parte central del interior del cráneo. La tomografía simple de cráneo reportó un trayecto de entrada en línea paramediana izquierda, además de ruptura del ventrículo lateral izquierdo y alojamiento del cuerpo extraño en el tercer ventrículo. El equipo de Neurocirugía descartó llevar a cabo algún procedimiento quirúrgico, debido a la localización del cuerpo extraño. El paciente fue hospitalizado durante 10 días, recibió tratamiento con ceftriaxona (100 mg/kg/ día) por cinco días. Permaneció asintomático, con cicatrización adecuada del orificio de entrada. En la última revisión, 12 años después del evento, la exploración física y neurológica no reportó manifestaciones ni complicaciones. Actualmente tiene 20 años y mantiene un buen estado de salud.CONCLUSIONES: Es necesario que las "armas de juguete" sean etiquetadas como artículos peligrosos. Se recomienda adecuar leyes para la venta y uso de las armas neumáticas.
Giant Cystic Pancreatic Lymphangioma with Mediastinal Extension: A Case Report and Review of the Literature
Authors: F Sánchez-Bueno , M Torres Costa , J De la Peña , M Fuster , G Torres , P Parrilla
Published: November 2019

Lymphangioma is an infrequent benign tumour that is formed usually from a congenital malformation of the lymphatic ducts causing lymphangiectasis. The abdominal location represents 1-5%, with dominance in the mesentery and retroperitoneum, however, the pancreatic location is very rare having described less than 100 cases published worldwide. The clinical symptoms of the lymphangiomas are non-specific and depend of the tumour’s size and location. Here we present a clinical case of a pancreatic lymphangioma with mediastinal extension who was treated with a complete resection and this case shows that the diagnosis of cystic pancreatic lymphangioma must be taken as a differential diagnosis of pancreatic cystic lesions.
Edukacja do równości i różnorodności na polskich uczelniach technicznych
Authors: Pietrzak Edyta
Published: November 2019

Potrzeba włączania perspektywy równości i różnorodności do badań naukowych i programów kształcenia wykracza poza nauki społeczne czy humanistyczne i odnosi się także do nauk technicznych kształcenia inżynieryjnego. Jak polskie uczelnie techniczne radzą sobie z tym wymogiem? Czy jest w ich działalności miejsce na uświadamianie studentom wagi kompetencji społecznych? Spróbujmy zatem odpowiedzieć na pytania o miejsce równości i różnorodności w misjach uczelni, badaniach naukowych, programach kształcenia oraz projektach społecznych i edukacyjnych realizowanych na politechnikach, odnosząc się przy tym do światowych dobrych praktyk w tym obszarze.
Równouprawnienie płci w debacie parlamentarnej Sejmu Ustawodawczego 1947–1952. Zarys problemu
Authors: Chrobaczyńska-Plucińska Edyta
Published: November 2019

Artykuł zawiera analizę charakteru debaty sejmowej dotyczącej równouprawnienia kobiet i mężczyzn, z uwzględnieniem problematyki ochrony praw dzieci, która toczyła się w Sejmie Ustawodawczym RP w latach 1947–1952. W podjętych rozważaniach wykorzystano metodę krytycznej analizy treści dostępnych materiałów źródłowych oraz metodę biograficzną, poszukując odpowiedzi na pytanie, kim były posłanki walczące o prawa kobiet w okresie stalinizmu, a także, czy ich aktywność nosiła znamiona sprawczości? Podstawę źródłową stanowią sprawozdania stenograficzne z posiedzeń sejmu, prasa oraz literatura wspomnieniowa. Intencją posłanek, m.in. M. Jaszczukowej, E. Pragierowej, I. Sztachelskiej, S. Garncarczykowej oraz Z. Tomczyk, była realizacja postulatu zmiany przepisów prawnych w taki sposób, aby zasada równouprawnienia kobiet stała się możliwa w praktyce. Było to również sztandarowe hasło przedstawicieli nowej, komunistycznej władzy ludowej i jednocześnie początek okresu określanego w historiografii mianem stalinizacji kraju. Procedowano normy i przepisy, które miały stworzyć warunki prawne, a tym samym urealnić możliwość podejmowania przez kobiety aktywności na różnych polach na równi z mężczyznami. Istniejący dysonans pomiędzy postulatami uprawomocnianymi ideologią a normami kulturowymi nie przeszkodził w nowelizacji prawa. Posłanki inicjujące te zmiany mogły mieć poczucie sprawstwa, a ich działania z pewnością przyczyniły się do zmian na rzecz równouprawnienia płci w Polsce tego okresu.
Knitting – (wo)men’s occupation
Authors: Kępa Ewa
Published: November 2019

Does a man who knits demonstrate courage? The question refers to the meanings attributed to knitting, which has traditionally been perceived as a female occupation performed in private space. In this article, referring to the past and the analysis of contemporary craft practice, I describe the process of deconstruction in this area. I am particularly interested in men knitting in public. The aim of my considerations is to analyze the difference between the meaning of what is male and female in knitting, and between hegemonic practice and subversive acts of deconstruction.
Kobiecość odebrana? Zjawisko anty-body shamingu wobec kobiet szczupłych – analiza socjologiczna
Authors: Okrój-Kowalska Agnieszka
Published: November 2019

Tekst ma na celu zwrócenie uwagi na zjawisko wykluczania kobiet szczupłych z anty-body shamingu, którego pierwotnym celem było złamanie ram dotyczących kobiecej sylwetki i ukazanie, że kobiece ciało niedefiniowane powszechnie jako szczupłe nie jest powodem do wstydu. Artykuł stanowi wprowadzenie do tematu stygmatyzacji kobiet szczupłych kosztem kobiet otyłych.
„Męskie” sposoby na bycie „fit”. Analiza porównawcza wybranych polskich blogów
Authors: Maj Agnieszka
Published: November 2019

Celem artykułu jest opisanie specyfiki wybranych polskich blogów poświęconych zdrowemu stylowi życia adresowanych do mężczyzn i prowadzonych przez mężczyzn. Autorka podejmuje próbę odpowiedzi na pytanie, jakie są cechy charakterystyczne „męskiego” podejścia do zdrowego stylu życia, mając na uwadze to, jak w tekstach poświęconych zdrowiu i sprawności autorzy odnoszą się do ideału męskości i stereotypów dotyczących mężczyzn. Jedną z wykorzystanych w artykule koncepcji teoretycznych są dwa przeciwstawne modele męskości opisane przez Krzysztofa Arcimowicza (2008) – „tradycyjny paradygmat męskości” oraz „nowy paradygmat męskości”.

Analizie poddano siedem wybranych blogów odnoszących się do zdrowego stylu życia. Zostały one dobrane arbitralnie i w sposób celowy. Analizowano szczególnie trzy aspekty badanych blogów: sposób rozumienia przez wybranych blogerów zdrowego stylu życia, preferowany przez blogerów model sylwetki oraz sposoby motywowania odbiorców do dbałości o wygląd i kondycję fizyczną. Jako metodę badawczą zastosowano niesystematyczną jakościową analizę treści. Najważniejsze wnioski z badań wskazują, że dominującym ideałem sylwetki, do którego odwołują się autorzy blogów, jest model mezomorficzny. W zamieszczanych wpisach dominuje ujęcie holistyczne, na które składają się takie ważne aspekty, jak zdrowie, atrakcyjny wygląd i sprawność fizyczna. Na blogach pojawiają się rozmaite dyskursy dotyczące męskości i męskiego ciała, jednak trudno wyodrębnić jeden dominujący wzorzec męskości, raczej konkurują one ze sobą, a blogerzy czerpią z różnych z nich.
Prawa strony postępowania w sprawie przymusowej restrukturyzacji banku (resolution)
Authors: Chojecka Katarzyna
Published: November 2019

Artykuł stanowi analizę praw strony postępowania w sprawie przymusowej restrukturyzacji (resolution). Regulacja ta, ukształtowana w formie postępowania administracyjnego, służy usprawnieniu restrukturyzacji lub likwidacji podmiotów zagrożonych upadłością w taki sposób, by w miarę możliwości zmaksymalizować bilans aktywów zagrożonego podmiotu, ale i by w jak najmniejszy sposób zaangażować środki publiczne, a kosztami procedury obciążyć raczej akcjonariuszy i wierzycieli podmiotu. Mechanizm ten jest traktowany jako środek ostateczny, gdy wszelkie inne środki nie będą w stanie uchronić sektora przed ryzykiem kryzysu. W ramach polskiej regulacji znacząco ograniczone zostały prawa strony postępowania administracyjnego. Przepisy wyłączają stosowanie zasady czynnego udziału stron w postępowaniu, możliwość wniesienia odwołania od decyzji oraz ograniczają możliwość otrzymania odszkodowania za nieprawidłową decyzję, jak też skracają terminy do zaskarżenia decyzji do sądu administracyjnego. Artykuł analizuje te restrykcje w kontekście celów resolution i zestawia je z możliwą niezgodnością przepisów z Konstytucją RP.
Functional typological approach to Shawi indeterminate pronouns
Authors: Ulloa Luis
Published: November 2019

This study describes the formation of indeterminate pronouns in Shawi, which is a class of proforms that can have interrogative, indefinite, and free relative senses. These interpretations are only distinguished through a class of clitics, e.g. ma’=ta (what, relative what), ma’=sha (something), ma=nta (nothing). The first of these can be further modified to ma’ta=ka (rhetorical what) and ma’=tana (whatever). As in other languages, this class of proforms can be categorized into a paradigm in which each member represents a general concept like person (who), thing (what), place (where), time (when), manner (how), etc. Comparing these forms reveals further internal structure. As such, Shawi indeterminate pronouns are analyzed and the clitics that can modify their interpretation are discussed.
Hubungan Lingkungan Kerja dengan Gejala Sick Building Syndrome pada Pegawai BPJS Kesehatan Depok Tahun 2019
Authors: Asri Annisa Nanda , Pulungan Rafiah Maharani , Fitri Azizah Musliha
Published: November 2019

Sick building syndrome (SBS) merupakan kumpulan keluhan yang dirasakan oleh pegawai yang bekerja di dalam ruangan dengan kualitas udara yang kurang baik. Pegawai BPJS Kesehatan Kota Depok bekerja dalam ruangan yang tertutup dengan pencahayaan dan iklim kerja yang kurang baik sehingga berpotensi mengalami gejala seperti kelelahan, sakit kepala, dan nyeri punggung. Tujuan penelitian ini menganalisis hubungan lingkungan kerja dengan gejala Sick Building Syndrome pada pegawai BPJS Kesehatan Kota Depok tahun 2019. Penelitian menggunakan metode kuantitatif dengan desain studi cross sectional. Sampel dalam penelitian ini berjumlah 70 orang pegawai BPJS Kesehatan Kota Depok. Variabel lingkungan fisik diperoleh berdasarkan hasil pengukuran lingkungan, sedangkan variabel lingkungan non fisik dan karakteristik individu menggunakan kuesioner. Analisis data menggunakan uji Chi Square dan uji Fisher’s Exact. Hasil penelitian menunjukkan terdapat hubungan antara pencahayaan (p=0,001), umur (p=0,006), kondisi psikososial (0,025), kebiasaan merokok (p=0,025), dan riwayat penyakit (p=0,038) dengan gejala SBS. Variabel yang tidak berhubungan dengan gejala SBS adalah iklim kerja (p=0,191), hubungan kerja pegawai dan atasan (p=0,447), hubungan kerja antar pegawai (p=1,000), jenis kelamin (p=0,506), dan masa kerja (p=1,000). Gejala SBS yang paling banyak adalah kantuk. Berdasarkan hasil tersebut, disarankan BPJS Kesehatan Kota Depok memperbaiki pencahayaan, melakukan peregangan di sela jam kerja, dan melakukan medical check up untuk meningkatkan kenyamanan pegawai dalam bekerja.
Characterization of Cellulosic Cotton Residue Produced by Sanding Process and Applied to Cement Pastes
Authors: Lima Mailon , Freitas Julio , Santos Caroliny , Santos Thiago , Oliveira Heriberto , Braga Renata
Published: November 2019

Fiber-cement composites were prepared from cellulosic cotton residue (CCR) arise from sanding process (emerizing). The effect of different concentrations: 0.5% and 1%, and granulometry: thick (retained in a14 mesh sieve) and thin (retained in a 48 mesh sieve) of this residue were evaluated on tensile strength of cement slurries with seven (07) curing days. To characterize the CCR, TGA, FT-IR, SEM and XRD analysis were performed and the residue resistance in an alkaline environment was also evaluated. Splitting tensile strength test, known as Brazilian Test, was used to assess effects of the fibers on the mechanical behavior of cement matrix. Analyzing the results, the CCR proved to be resistant in an alkaline environment, meaning that it can withstand the alkaline environment of cement matrix. The results showed an improvement superior to 17% in tensile strength for 1% of CCR. Therefore, the CCR presents a great application potential in cement pastes used for oil well cementing that requires to increase its tensile strength, once a significant improvement was achieved with a low-residue employee.
Karakterisasi biokomposit sheep hydroxyapatite (sha)/shellac/tepung terigu
Authors: Mahfudi Izmi , Triyono Joko , Triyono Teguh
Published: November 2019

The development of science and technology has led to new inovations in the medical field, especially ortopedic. The aim of those inovations is to find the alternatives of good materials that can replace the broken sturcture of bone tissue. One of the innovations conducted is the characterization of sheep hydroxyapatite biocomposite. This study aims to investigate the mechanical properties of the material Sheep Hydroxyapatite (SHA) / shellac / wheat fluor. Sheep bone powder already gained from the crusher process and meshing into size of 100 and are soaked for 24 hours, then mixed with wheat flour with the ratio 30 : 70 %wt, 40 : 60 %wt, 50 : 50 %wt, 60 : 40 %wt, 70 : 30 %wt. The next step is the forming process and calcination at a temperature of 900oC with a increase of 10 °C/min. Results of X-Ray Diffraction (XRD) shows that the diffraction peak of SHA/shellac/wheat flour is the value of 2θ: 32.0747º, 33.1943º, 32.5338º. The lowest hardness number of SHA/shellac/wheat flour is 2.86 VHN and the highest is 14.80 VHN, also the highest strong pressure number is 0.20 MPa. The result of microscophy at observation using SEM shows Thar the SHA/shellac/wheat flour 50:50 % wt sample has more porosity as.
Analisis simulasi pengaruh ratio overlap sudu terhadap unjuk kerja savonius horizontal axis water turbine
Authors: Khuluqi Hasnul , Hadi Syamsul , Danardono Dominicus
Published: November 2019

The rainwater which is harvested and flowed in a 3 inch diameter pipe has potential energy that can be used to generate the turbine generator for producing electricity. This paper was focused on horizontal axis savonius turbine with varied blade overlap ratio in picohydro generator. Savonius turbine is known to utilize the drag force and work efficiently at low velocity. The purpose of this research is to find out optimal torque of savonius water turbine, and flow distribution. The results showed that the flow rate of 11.9 l/s with the overlap variation of 0.3 obtained the maximum torque value of 5,22 Nm.
Effect of Fluid Pressure and Pore Structure on Tight Sand Gas Saturation—Evidence from Micro-CT Simulation Experiment
Authors: Gong Yanjie , Zhao Mengjun , Zhuo Qingong , Liu Keyu
Published: November 2019

Numerous technical papers have been published on the reservoir evaluation of tight sand gas in recent decades. It is believed that tight sand gas is characterized by low permeability, complex pore structure, abnormal pressure, and low gas saturation. Researchers have characterized tight gas in terms of, for example, statistics; and some of them are increasingly interested in the effect of fluid pressure and pore structure on gas saturation. However, there is still a lack of effective experimental and mechanism analysis.

The focus of this paper is to investigate the effect of two factors on controlling the tight gas saturation. A method was proposed for determining the in-situ injection pressure of the DB 2 gas reservoir in the Kuqa area during the gas-accumulation period, and the result was 1.2 MPa. A polyetheretherketone carbon-fiber core holder (maximum temperature 180 °C, maximum confining pressure 30 MPa) was designed for the microcomputed-tomography (CT) simulation experiment. After that, four physical simulation experiments of different fluid pressures (0.1, 0.5, 1.5, and 5.0 MPa) were implemented using X-ray CT and the new core holder to study the effect of fluid pressure and pore structure on gas saturation.

The results show that the fluid pressure and micropore connectivity are important factors for gas-saturation increase; the number of gas clusters (connected pores containing gas) increases with the increase of fluid pressure and the maximum volume of gas clusters increases with the increase of pore connectivity. The connected pores with the largest volume are an important source of gas-saturation contribution. The three types of modes (the blowing balloon mode, stitching mode, and composite mode) of microscopic gas-cluster formation are discussed. The blowing balloon mode is key to gas-saturation growth in the period of low fluid pressure or the early stage of the injection process. The stitching mode is key to gas-saturation growth in the period of high fluid pressure or the late stage of the injection process.

The above research system investigates the quantitative control of fluid parameters (pressure) and reservoir parameters (pore structure) on gas saturation, which might change the situation where previous research was too focused on the pore-structure and fluid-pressure characterization, with a lack of quantitative control analysis of reservoir gas saturation. It provides a valuable reference and framework for the reader to conduct further quantitative research on tight gas saturation.
Impact of lifestyle on carotid vascular pathogenesis is mediated by the gut microbiome: A population-based analysis of gut microbiome in Chinese elderly
Authors: Zhu Sibo , Xu Kelin , Jiang Yanfeng , Suo Chen , Cui Mei , Wang Yingzhe , Yuan Ziyu , Xue Jiangli , Wang Jiucun , Zhang Tiejun , Zhao Genming , Ye Weimin , Huang Tingting , Lv Ming , Tian Weizhong , Jin Li , Chen Xingdong
Published: November 2019

Background The altered microbiota, considered as quantitative traits has also been identified to play pivotal roles in the host vascular physiology and might contribute to diseases. To understand the role of fecal microbiota on the vascular physiology in the healthy elderly population and how lifestyle such as diet and income shape the composition of host gut microbiota to further impact pathogenesis of carotid vascular diseases.Results We performed a population-based fecal metagenomic study over 569 elderly asymptomatic healthy individuals in rural China. An association network was built based on clinical measurements and detailed epidemiologic questionnaires including blood chemistry, arterial stiffness, carotid ultrasonography, and metagenomic datasets. Carotid arterial atherosclerosis indices including intima-media thickness (IMT) were shown essential in the network and were significantly associated with lifestyles and diet. Fresh fruit, fresh vegetables, and fresh aquatic food can significantly reduce carotid artery IMT, especially in the mediation of Alistipes and Parabacteroides genus. Higher income, and exercise which are shown to improve carotid arteries mediated by Prevotella and Oligella genus.Conclusions Our study provided a Chinese population-wide phenotype-metagenomic network, revealing association and mediation effect of gut microbiota on carotid atherosclerosis by lifestyle, hinting at a therapeutic and preventive potential of microbiota in cardiovascular diseases.
Identification of Cell cycle Gene Signatures Predicting Survival in Patients with Lung Squamous Cell Carcinoma
Authors: Zhang Lei , Zhang Zhe , Yu Zhenglun
Published: November 2019

Background:Lung cancer (LC) is one of the most important and common malignant tumors, and its incidence and mortality are increasing annually. Lung squamous cell carcinoma (LUSC) is the common pathological type of lung cancer. A small part of biomarkers have been confirmed to be related to the prognosis and survival by data excavation. However, the moderate forecast effect of a single gene biomarker is not accurate. Thus, we aimed to identify new gene signatures to better predict Lung squamous cell carcinoma ( LU SC). Methods : Using the mRNA-mining approach, we performed mRNA expression profiling in large lung squamous cell carcinoma cohorts (n= from The Cancer Genome Atlas (TCGA) database. Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis(GSVA) were accomplished, and connections between genes and cell cycle were found in the Cox proportional regression model. Results : We have confirmed a set of four genes (CDKN1A, CHEK2, E2F4 and RAD21) that were importantly associated with overall survival (OS) in the test series. Based on the research of the four-gene signature, the patients in the test series could be divided into high-risk and low-risk teams. Additionally, multivariate Cox regression analysis revealed that the prognostic power of the four-gene signature is independent of the clinical factors. Conclusion : Our study demonstrated the connections between the four-gene signature and cell cycle. Novel insights into the research mechanisms of cell cycle was also revealed regarding the biomarkers of a poor prognosis for lung squamous cell carcinoma patients.
Midodrine for Prevention of Intradialytic Hypotension in High Risk Patients at a Tertiary Referral Hospital: A Retrospective Study
Authors: alhabardi Saja M , Aldhaefi Maryam , Alessa Mohammed , Alammari Maha , Alrajhi Yousef , Bustami Rami
Published: November 2019

Background:
Intradialytic hypotension (IDH) is the most common complication during hemodialysis procedure. Midodrine, an oral α-1 adrenergic agonist, is commonly used to prevent IDH. However, limited data is available to demonstrate midodrine effectiveness in prevention of IDH in high-risk hemodialysis patients.
Objective:
To describe the clinical outcomes of using midodrine in patients receiving hemodialysis concerning the incidence of IDH. Also, we aimed to explore the appropriate dose for midodrine use to prevent IDH.
Methodology
A retrospective cohort of adult with end-stage-renal failure.
Exposure: Midodrine.
Outcomes measure: IDH was defined as a decline in systolic blood pressure (SBP) by ≥20 mmHg or a decline in main arterial pressure (MAP) by ≥10 mmHg during hemodialysis session. Recurrent IDH was defined as three or more episodes of IDH throughout a year of starting midodrine.
Analysis: A descriptive analysis of the frequency of IDH and recurrent IDH. We also, compared the risk of recurrent IDH across various doses of midodrine use.
Result:
From a total of 68-screened patients’ charts, 45 patients were included in the final analysis. 41.8% (n=28) of the study population had an IDH that required additional interventions to restore the SBP and MAP. IDH occurred in 68% (n=19, P=0.03) of patients with hypoalbuminemia. Recurrent IDH occurred in 36% (n=16) of the patients over their hemodialysis procedure. Incidence of treatment failure (57%, p= 0.02) and recurrent IDH (36%, p=0.04) were statistically significant in patients who received midodrine three time per week (57%) in comparison to those who received more than three days per week
Conclusion:
This exploratory study shows that a considerable proportion of patients receiving midodrine did not develop IDH or recurrent IDH. A long-term follow-up study with larger number of patients in comparison to the control group would be useful to evaluate the magnitude of efficacy of midodrine in hemodialysis patients with high risk for IDH. Moreover, a future prospective trial that focus on an important clinical outcomes such as cardiovascular events and mortality with midodrin is warranted.
Improving Nitrogen Fertilizer Use Efficiency in Subsurface Drip‐Irrigated Cotton in the Desert Southwest
Authors: Bronson Kevin. F. , Hunsaker Douglas J. , Meisinger John J. , Rockholt Sharette M. , Thorp Kelly R. , Conley Matthew M. , Williams Clinton F. , Norton E. Randall , Barnes Edward M.
Published: November 2019

Declining water availability in the American Southwest continues to generate interest in efficient subsurface drip irrigation (SDI) for cotton (Gossypium hirsutum L.) production. Fertigating urea ammonium nitrate (UAN) at low rates with high frequency is an important advantage of SDI. However, N fertilizer management guidelines specific to SDI cotton are lacking. A 3‐yr study was conducted on a Casa Grande sandy loam soil in Maricopa, AZ, to test a pre‐plant soil profile NO3 test algorithm and a canopy reflectance approach to manage in‐season N fertilizer for SDI cotton. Treatments included soil test‐based N management, reflectance‐based N management, and zero‐N at 100% evapotranspiration irrigation replacement. A second irrigation level of 70% evapotranspiration replacement included just the soil test‐based N and zero‐N treatments. The five treatments were replicated three times. Soil test–based N treatments received from 172 to 224 kg N ha−1, and reflectance‐based N amounts were 112 to 158 kg N ha−1. Nitrogen recovery efficiency (RE) of UAN‐N was high, with 24 fertigations during 6 wk between first square and mid bloom ranging from 58 to 93%. The isotope dilution method estimated similar RE in 2017. Residual post‐harvest soil NO3–N was notable only with 70% irrigation. Lint and seed yields were significantly reduced with the 70% irrigation treatment compared with 100% irrigation. The key result of this study is that reflectance‐based N management saved 17 to 112 kg N ha−1 without reducing lint yields compared with the soil test–based N treatment.
Calidad de vida de pacientes con diabetes tipo 2 en Colombia. Revisión sistemática y metaanálisis acumulativo
Authors: Palacios-Barahona Uriel , Arango-Posada María del Mar , Ordoñez Jaime E. , Alvis-Guzman Nelson
Published: November 2019

Antecedentes: La calidad de vida (CV) relacionada con la salud es un indicador de desempeño de los sistemas sanitarios; no obstante, se desconoce su estado en personas con diabetes tipo 2, lo que limita la implementación y evaluación de intervenciones dirigidas a mejorar su salud. Objetivo: Identificar los dominios más afectados en la CV de pacientes con diabetes tipo 2. Método: Búsqueda sistemática en las bases de datos LILACS, Pubmed, Embase y Google Académico, de estudios observacionales que midieron de manera cuantitativa la CV de pacientes con diabetes tipo 2, sin importar la comorbilidad o estado funcional, en el contexto ambulatorio u hospitalario en Colombia. Para identificar los dominios más afectados se realizó un metaanálisis acumulativo de estudios observacionales que midieron la CV con los Cuestionarios de Salud SF-36 (Short Form-36) y SF-8 (Short Form-8), y se realizó un modelo de efectos aleatorios que permitió la estimación de las medias como medida de efecto combinado. Resultados: Se identificaron siete artículos, de los cuales cuatro fueron incluidos en la síntesis cuantitativa. Los dominios de la CV de los pacientes con diabetes tipo 2 más afectados según los Cuestionarios SF-36 y SF-8 fueron salud general 49,7 (IC 95%: 37,3 a 62,0), rol físico 53,6 (IC 95%: 35,6 a 71,6) y función física 53,8 (IC 95%: 34,8 a 72,8). Conclusión: Los programas preventivos y de atención a personas con diabetes tipo 2 deben enfocarse en un manejo integral que contribuya al mejoramiento de su CV relacionada con su salud.
Melatonin: Implications for Ocular Disease and Therapeutic Potential
Authors: Scuderi Luca , Davinelli Sergio , Iodice Clemente Maria , Bartollino Silvia , Scapagnini Giovanni , Costagliola Ciro , Scuderi Gianluca
Published: November 2019

Melatonin, an indoleamine secreted mainly by the pineal gland, is known to modulate a wide range of
circadian functions. However, this neurohormone is also synthesized within the eye and acts directly on ocular
structures to mediate a variety of physiological processes. This review is focused on the role and therapeutic
potential of melatonin in ocular diseases. We summarize data indicating that melatonin may represent a powerful
tool to counteract ocular dysfunctions such as uveitis, glaucoma, age-related macular degeneration, and diabetic
retinopathy. A search strategy was conducted to identify studies in PubMed (January 1990 to September 2017). In
particular, we included experimental studies, clinical trials, and reviews to provide suitable insights and elucidations
regarding the action of melatonin on age-related ocular disorders. Literature data suggest that melatonin
could potentially protect ocular tissues by decreasing the production of free radicals and pro-inflammatory mediators.
Additionally, melatonin appears to be safe and well-tolerated, even at high doses, and no adverse/side effects
were reported. Although this topic remains under intense investigation, we can conclude that melatonin, as a
single agent or in combination with other drugs, is an attractive pharmacological candidate for age-related ocular
diseases.
Effect of Escherichia Coli Infection on Metabolism of Dietary Protein in Intestine
Authors: Peng Xiao-Pei , Ding Wei , Ma Jian-Min , Zhang Jie , Sun Jian , Cao Yun , Lei Li-Hui , Zhao Jinshan , Li Yun-Fu
Published: November 2019

Dietary proteins are linked to the pathogenic Escherichia coli (E. coli) through the intestinal
tract, which is the site where both dietary proteins are metabolized and pathogenic E. coli strains play a
pathogenic role. Dietary proteins are degraded by enzymes in the intestine lumen and their metabolites
are transferred into enterocytes to be further metabolized. Seven diarrheagenic E. coli pathotypes have
been identified, and they damage the intestinal epithelium through physical injury and effector proteins,
which lead to inhibit the digestibility and absorption of dietary proteins in the intestine tract. But
the increased tryptophan (Trp) content in the feed, low-protein diet or milk fractions supplementation
is effective in preventing and controlling infections by pathogenic E. coli in the intestine.
A chlorhexidine-containing brush-on gel as adjuvant treatment for plaque induced gingivitis.
Authors: Nardi Gianna Maria , Grassi Roberta , Campus Guglielmo , Pareti Maria Letizia , Di Stasio Dario , della Vella Fedora
Published: November 2019

Aim:

The aim of the present study was to evaluate the effects of a chlorhexidine brush-on gel application on plaque-induced gingivitis.

Materials & Methods:

: Consecutive patients diagnosed with gingivitis were enrolled. For each patient, full mouth plaque score and gingival index were recorded during the first visit (t0) and after 1 week (t1), 2 weeks (t2) and 3 weeks (t3). Patients were randomly divided into a study group, who received instruction to brush their teeth daily with a chlorhexidine-based gel, and a control group, treated with a placebo gel. The chi-square test was used to compare the groups baseline, while the t-Student and the Mann-Whitney tests were performed to evaluate the significance of groups indexes improvement, individually and compared.

Results:

Thirty participants were enrolled: 15 referred to the study group and 15 to the control group. The study group showed a reduction of plaque score and gingival index of 87% and 84% respectively (p<0.05), while the control group plaque score and gingival index decreased of 75% and 80% (p<0.05). The study group plaque score reduction resulted to be statistically more significant than the control group one.

Conclusions:

The topical application of a chlorhexidine-based brush-on gel can be a useful adjunctive domiciliary treatment for gingivitis therapy, combined with the mechanical debridement, that still remains the gold standard.
Dietary Exposure of Heavy Metals, Minerals and Trace Elements through Cereals Commonly Consumed by Dhaka City Residents
Authors: Hosen Md. Bayejid , Abdullah Abu T.M. , Howlader Md. Z.H. , Kabir Yearul
Published: November 2019

Background:

Contamination of soil and agricultural products by heavy metals resulting
from rapid industrial development has caused major concern. Dietary exposure to heavy metals has
been associated with toxic and adverse health effects. The main threats to human health from heavy
metals are associated with exposure to Pb, Cd and Hg. The aim of this study was to monitor the presence
of heavy metals, minerals and trace elements in cereals consumed by Dhaka city residents.

Methods:

One hundred and sixty cereal samples were collected for eight (08) composited samples
and analyzed for the determination of sixteen elements. Heavy metals were analyzed by Inductively
Coupled Plasma Mass Spectrometry (ICP-MS), and other elements were determined by Atomic Absorption
Spectrometry (AAS).

Results:

The average concentrations of elements in cereals fall within the safe limit except for Pb,
Cr, Na and Mg, which exceeded the safe limits. The daily intake of Cd (23.0 μg), Hg (63.0 μg) and
As (13.6 μg) through cereals was below the risk level except for Pb (634.0 μg) and Cr (263.1 μg).
The dietary intake of Na (1860.0 mg), Mg (347.0 mg) and Mn (4600.0 μg) exceeded the toxic level
while K (829 mg) was below the RDA.

Conclusion:

As the main meal of average Bangladeshi people is boiled rice served with some vegetables,
our findings indicate that the residents of Dhaka city are at risk from Pb and Cr contamination
and their dietary need for some important minerals and trace elements is not fulfilled by cereals.
Does Placental Weight Affects Perinatal Outcome? A Prospective Case-control Study
Authors: Kumar Naina , Agarwal Himani
Published: November 2019

Background:

Placenta plays a very important role in the growth and development of
fetus.

Objective:

To know the correlation between placental weight and perinatal outcome in term antenatal
women.

Methods:

Present prospective case-control study was conducted in the rural tertiary center of
Northern India over one year (January-December 2018) on 1,118 term (≥37-≤42 weeks) antenatal
women with singleton pregnancy fulfilling inclusion criteria with 559 women with high-risk pregnancy
as cases and 559 low-risk pregnant women as controls. Placental weight, birth weight was
measured immediately after delivery and compared between the two groups along with gestation,
parity, fetal gender, and neonatal outcome. Statistical analysis was done using SPSS 22 version.

Results:

Mean placental weight [481.98±67.83 gm vs. 499.47±59.59 gm (p=.000)] and birth weight
[2.68±0.53 Kg vs. 2.88±0.4 Kg (p=.000)] was significantly lower in high risk as compared to lowrisk
participants, whereas placental birth weight ratio was higher in high-risk cases [18.35±2.37 vs.
17.41±1.38 (p=.000)] respectively. Placental weight was positively correlated with birth weight and
placental weight and birth weight increased with increasing gestation in both cases and controls.
Male neonates had higher placental weight [492.74±68.24 gm vs. 488±58.8 gm (p=0.224)] and birth
weight [2.81±0.5 Kg vs. 2.74±0.45 Kg (p=0.033)] as compared to females. Neonatal Intensive Care
Unit admission was significantly associated with low placental and birth weight (p=.000).

Conclusion:

There is a significant correlation between placental weight, birth weight and neonatal
outcome, hence placental weight can be used as an indirect indicator of intrauterine fetal growth.
Detoxifying Action of Aqueous Extracts of Mucuna pruriens Seed and Mimosa pudica Root Against Venoms of Naja nigricollis and Bitis arietans
Authors: Ameh Matthew P. , Mohammed Mamman , Ofemile Yusuf P. , Mohammed Magaji G. , Gabriel Ada , Isaac Akefe O.
Published: November 2019

Background:

The World Health Organization included snakebite envenomation among
Neglected Tropical Diseases in 2017. The importance of natural products from plants is enormous,
given that most prescribed drugs originate from plants. Among this is Mucuna pruriens and Mimosa
pudica, with many registered patents asserting their health benefits.

Objective:

This study investigated the in vitro neutralizing effects of Mucuna pruriens seed and
Mimosa pudica root extracts on venoms of Naja nigricollis and Bitis arietans.

Methods:

In mice, the LD50 and phytochemical analysis of M. pruriens and M. pudica plant extracts
were carried out prior to the evaluation of their haemolytic and fibrinolytic effect. Their effects
on the activities of phospholipase A2 (PLA2) were also assessed.

Results:

At a concentration of 50 mg/ml, both plant extracts were found to neutralize the fibrinolytic
activity of N. nigricollis, but 400 mg/ml was required to neutralize the fibrinolytic activity
of B. arietans. In haemolytic studies, 50 mg/ml concentration of M. pruriens extract suppressed
haemolysis caused by N. nigricollis venom by 70% but at the same concentration, M. pudica extract
reduced haemolysis by 49.4%. M. pruriens, at 50 mg/ml concentration, only inhibited phospholipase
A2 activity by 7.7% but higher concentrations up to 400mg/ml had no effect against the
venom of N. nigricollis; at 200 mg/ml. M. pudica extract inhibited PLA2 activity by 23%.

Conclusion:

The results suggest that M. pruriens and M. pudica may be considered as promising
antivenom agents for people living in a snake-bite prone environment.
CULTURE BASED TEACHING AND LEARNING FOR INDONESIAN AS A FOREIGN LANGUAGE IN YOGYAKARTA
Authors: Zuchdi Darmiyati , Nurhadi Nurhadi
Published: November 2019

The practice of culture-based teaching and learning Indonesian as a foreign language (T&LIFL) has not been well managed and standardized. Therefore, this study attempted to investigate T&LIFL at six universities in Yogyakarta. The investigation consisted of some cultural aspects in terms of program management, learning material, learning media, teaching approaches, methods, and strategies, learning assessment, and program evaluation. The research design was a mix method design. To collect data, it used questionnaires, interviews, and observations. The data then were analysis quantitatively and qualitatively. The research results were (1) T&LIFL program management had not been culture-based, (2) T&LIFL learning material had not been entirely culture-based, (3) there were not enough learning media reflected on culture, (4) approaches, methods, and strategies had not used learning models including language learning, language awareness, cultural awareness, and cultural experience, (5) the assessment of culture-based learning had not been carried out with process assessment, but some have already packed it in cultural festivals at the end of the program, and (6) there was no evaluation on T&LIFL programs that explicitly evaluated program achievements on aspects of  culture awareness, and experience.
PediTools Electronic Growth Chart Calculators: Applications in Clinical Care, Research, and Quality Improvement
Authors: Chou Joseph H , Roumiantsev Sergei , Singh Rachana
Published: November 2019

Background

Parameterization of pediatric growth charts allows precise quantitation of growth metrics that would be difficult or impossible with traditional paper charts. However, limited availability of growth chart calculators for use by clinicians and clinical researchers currently restricts broader application.

Objective

The aim of this study was to assess the deployment of electronic calculators for growth charts using the lambda-mu-sigma (LMS) parameterization method, with examples of their utilization for patient care delivery, clinical research, and quality improvement projects.

Methods

The publicly accessible PediTools website of clinical calculators was developed to allow LMS-based calculations on anthropometric measurements of individual patients. Similar calculations were applied in a retrospective study of a population of patients from 7 Massachusetts neonatal intensive care units (NICUs) to compare interhospital growth outcomes (change in weight Z-score from birth to discharge [∆Z weight]) and their association with gestational age at birth. At 1 hospital, a bundle of quality improvement interventions targeting improved growth was implemented, and the outcomes were assessed prospectively via monitoring of ∆Z weight pre- and postintervention.

Results

The PediTools website was launched in January 2012, and as of June 2019, it received over 500,000 page views per month, with users from over 21 countries. A retrospective analysis of 7975 patients at 7 Massachusetts NICUs, born between 2006 and 2011, at 23 to 34 completed weeks gestation identified an overall ∆Z weight from birth to discharge of –0.81 (P<.001). However, the degree of ∆Z weight differed significantly by hospital, ranging from –0.56 to –1.05 (P<.001). Also identified was the association between inferior growth outcomes and lower gestational age at birth, as well as that the degree of association between ∆Z weight and gestation at birth also differed by hospital. At 1 hospital, implementing a bundle of interventions targeting growth resulted in a significant and sustained reduction in loss of weight Z-score from birth to discharge.

Conclusions

LMS-based anthropometric measurement calculation tools on a public website have been widely utilized. Application in a retrospective clinical study on a large dataset demonstrated inferior growth at lower gestational age and interhospital variation in growth outcomes. Change in weight Z-score has potential utility as an outcome measure for monitoring clinical quality improvement. We also announce the release of open-source computer code written in R to allow other clinicians and clinical researchers to easily perform similar analyses.