bluuebunny/crossref_metadata_2025 huggingface dataset:
Geospatial Overlap of Undernutrition and Tuberculosis in Ethiopia
Authors: Wagnew Fasil , Alene Kefyalew Addis , Kelly Matthew , Gray Darren
Published: October 2023

Undernutrition is a key driver of the global tuberculosis (TB) epidemic, yet there is limited understanding regarding the spatial overlap of both diseases. This study aimed to determine the geographical co-distribution and socio-climatic factors of undernutrition and TB in Ethiopia. Data on undernutrition were found from the Ethiopian Demographic and Health Survey (EDHS). Data on TB were obtained from the Ethiopia national TB prevalence survey. We applied a geostatistical model using a Bayesian framework to predict the prevalence of undernutrition and TB. Spatial overlap of undernutrition and TB prevalence was detected in the Afar and Somali regions. Population density was associated with the spatial distribution of TB [β: 0.008; 95% CrI: 0.001, 0.014], wasting [β: −0.017; 95% CrI: −0.032, −0.004], underweight [β: −0.02; 95% CrI: −0.031, −0.011], stunting [β: −0.012; 95% CrI: −0.017, −0.006], and adult undernutrition [β: −0.007; 95% CrI: −0.01, −0.005]. Distance to a health facility was associated with the spatial distribution of stunting [β: 0.269; 95% CrI: 0.08, 0.46] and adult undernutrition [β: 0.176; 95% CrI: 0.044, 0.308]. Healthcare access and demographic factors were associated with the spatial distribution of TB and undernutrition. Therefore, geographically targeted service integration may be more effective than nationwide service integration.
Policing Social Disorder and Broken Windows Theory: Spatial Evidence from the “Franeleros” Experience
Authors: García-Tejeda Enrique , Fondevila Gustavo
Published: October 2023

There is ongoing debate regarding the association between disorder and criminality. The literature has shown mixed, reduced, or no effects between the two phenomena, although few studies have dealt with the problem in terms of social disorder and its spatial heterogeneity. Using official records, we analyzed crime incidence involving vehicles in Mexico City neighborhoods with a combination of spatial methods, classification algorithms, and non-parametric tests. We found that the presence of people who demand payment for taking care of cars (social disorder) is probably spatially linked to auto parts robbery (crime). It is possible that such social incivility sends a signal that encourages the commission of crimes upon the vehicles, forming spatial clusters due to the undesirable effects of public policies. Our findings enable the broken windows theory to improve its explanatory capacity, considering spatial hypotheses and complementing its explanations with other criminological theories.
Nε-Carboxymethyl-Lysine Modification of Extracellular Matrix Proteins Augments Fibroblast Activation
Authors: Ediga Harshavardhana H. , Hester Patrick , Yepuri Adithi , Reddy Geereddy Bhanuprakash , Madala Satish K.
Published: October 2023

The extracellular matrix (ECM) is a dynamic complex protein network that provides structural integrity and plays an active role in shaping fibroblast behavior both in health and disease. Despite its essential functions, the impact of age-associated post-translational modifications on ECM-driven fibroblast activities such as proliferation, survival, fibroblast-to-myofibroblast transformation (FMT), and extracellular matrix production remains largely unknown. Nε-carboxymethyl-lysine (CML) is one of the well-characterized advanced glycation end-products (AGEs) that can occur on lysine residues within ECM proteins through non-enzymatic glycation. In this study, we determined the accumulation and the effects of the CML-modified ECM (CML-ECM) on fibroblast activation. Immunostainings and immunoblot analysis demonstrated significant increases in CML-AGE content in idiopathic pulmonary fibrosis (IPF) compared to age-matched healthy lungs. Gene expression analysis and fibroblast activation assays collectively implicate the ECM as a negative regulator of fibroblast activation. Notably, the CML modification of the ECM resulted in a significant decrease in its anti-fibrotic effects including proliferation, FMT, apoptosis, and ECM production. Together, the results of this study revealed an unexplored pathological role played by the CML-ECM on fibroblast activation, which has wide implications in IPF and other fibrotic diseases.
Direct-Acting Antiviral Drug Modulates the Mitochondrial Biogenesis in Different Tissues of Young Female Rats
Authors: Hafez Hala A. , Atoom Ali M. , Khafaga Rana H. M. , Shaker Sara A. , Kamel Maher A. , Assem Nagwa M. , Mahmoud Shimaa A.
Published: October 2023

(1) Background: Hepatitis C virus (HCV) infection is endemic in Egypt, with the highest prevalence rate worldwide. Sofosbuvir (SOF) is a nucleos(t)ide analog that specifically inhibits HCV replication. This study aimed to explore the possible effects of the therapeutic dose of SOF on the mitochondrial biogenesis and functions of the liver, muscle, and ovarian tissues of young normal female rats. (2) Methods: This study was conducted on 20 female Wistar rats, classified into two groups, the control group and the exposed group; the latter was orally supplemented with 4 mg/kg/day of SOF for 3 months. (3) Results: The exposure to SOF impairs mitochondrial biogenesis via mitochondrial DNA copy number decline and suppressed mitochondrial biogenesis-regulated parameters at mRNA and protein levels. Also, SOF suppresses the DNA polymerase γ (POLG) expression, citrate synthase activity, and mitochondrial NADH dehydrogenase subunit-5 (ND5) content, which impairs mitochondrial functions. SOF increased lipid peroxidation and oxidative DNA damage markers and decreased tissue expression of nuclear factor erythroid 2-related factor 2 (Nfe2l2). (4) Conclusions: The present findings demonstrate the adverse effects of SOF on mitochondrial biogenesis and function in different tissues of young female rats, which mostly appeared in ovarian tissues.
Molecular Mechanism Biomarkers Predict Diagnosis in Schizophrenia and Schizoaffective Psychosis, with Implications for Treatment
Authors: Fryar-Williams Stephanie , Tucker Graeme , Strobel Jörg , Huang Yichao , Clements Peter
Published: October 2023

Diagnostic uncertainty and relapse rates in schizophrenia and schizoaffective disorder are relatively high, indicating the potential involvement of other pathological mechanisms that could serve as diagnostic indicators to be targeted for adjunctive treatment. This study aimed to seek objective evidence of methylenetetrahydrofolate reductase MTHFR C677T genotype-related bio markers in blood and urine. Vitamin and mineral cofactors related to methylation and indolamine-catecholamine metabolism were investigated. Biomarker status for 67 symptomatically well-defined cases and 67 asymptomatic control participants was determined using receiver operating characteristics, Spearman’s correlation, and logistic regression. The 5.2%-prevalent MTHFR 677 TT genotype demonstrated a 100% sensitive and specific case-predictive biomarkers of increased riboflavin (vitamin B2) excretion. This was accompanied by low plasma zinc and indicators of a shift from low methylation to high methylation state. The 48.5% prevalent MTHFR 677 CC genotype model demonstrated a low-methylation phenotype with 93% sensitivity and 92% specificity and a negative predictive value of 100%. This model related to lower vitamin cofactors, high histamine, and HPLC urine indicators of lower vitamin B2 and restricted indole-catecholamine metabolism. The 46.3%-prevalent CT genotype achieved high predictive strength for a mixed methylation phenotype. Determination of MTHFR C677T genotype dependent functional biomarker phenotypes can advance diagnostic certainty and inform therapeutic intervention.
Predicting COVID-19 Hospital Stays with Kolmogorov–Gabor Polynomials: Charting the Future of Care
Authors: Marateb Hamidreza , Norouzirad Mina , Tavakolian Kouhyar , Aminorroaya Faezeh , Mohebbian Mohammadreza , Mañanas Miguel Ángel , Lafuente Sergio Romero , Sami Ramin , Mansourian Marjan
Published: October 2023

Optimal allocation of ward beds is crucial given the respiratory nature of COVID-19, which necessitates urgent hospitalization for certain patients. Several governments have leveraged technology to mitigate the pandemic’s adverse impacts. Based on clinical and demographic variables assessed upon admission, this study predicts the length of stay (LOS) for COVID-19 patients in hospitals. The Kolmogorov–Gabor polynomial (a.k.a., Volterra functional series) was trained using regularized least squares and validated on a dataset of 1600 COVID-19 patients admitted to Khorshid Hospital in the central province of Iran, and the five-fold internal cross-validated results were presented. The Volterra method provides flexibility, interactions among variables, and robustness. The most important features of the LOS prediction system were inflammatory markers, bicarbonate (HCO3), and fever—the adj. R2 and Concordance Correlation Coefficients were 0.81 [95% CI: 0.79–0.84] and 0.94 [0.93–0.95], respectively. The estimation bias was not statistically significant (p-value = 0.777; paired-sample t-test). The system was further analyzed to predict “normal” LOS ≤ 7 days versus “prolonged” LOS > 7 days groups. It showed excellent balanced diagnostic accuracy and agreement rate. However, temporal and spatial validation must be considered to generalize the model. This contribution is hoped to pave the way for hospitals and healthcare providers to manage their resources better.
A New qPCR Assay for the Rapid Diagnosis of Anthonomus grandis Subspecies
Authors: Raszick Tyler Jay , Perkin Lindsey C. , Godoy Alejandra , Shirley Xanthe A. , Wright Karen , Martin Paxton T. , Suh Charles P. -C. , Ruiz-Arce Raul , Sword Gregory A.
Published: October 2023

Rapid and accurate identification of Anthonomus grandis subspecies is crucial for effective management and eradication. Current diagnostic methods have limitations in terms of time to diagnosis (up to seven days) and can yield ambiguous results. Here, we present the validation of a custom TaqMan SNP Genotyping Assay for the rapid and accurate identification of A. grandis grandis (boll weevil) and A. g. thurberiae (thurberia weevil) subspecies. To validate the assay, we conducted three main experiments: (1) a sensitivity test to determine the DNA concentration range at which the assay performs, (2) a non-target specificity test to ensure no amplification in non-target weevils (false positives), and (3) an accuracy test comparing the results of the new assay to previously established methods. These experiments were carried out in parallel at three independent facilities to confirm the robustness of the assay to variations in equipment and personnel. We used DNA samples from various sources, including field-collected specimens, museum specimens, and previously isolated DNA. The assay demonstrated high sensitivity (PCR success with ≥0.05 ng/µL DNA template), specificity (0.02 false positive rate), and accuracy (97.7%) in diagnosing boll weevil and thurberia weevil subspecies. The entire workflow, including DNA extraction, assay preparation, PCR run time, and data analysis, can be completed within a single workday (7–9 h) by a single technician. The deployment of this assay as a diagnostic tool could benefit boll weevil management and eradication programs by enabling same-day diagnosis of trap-captured or intercepted weevil specimens. Furthermore, it offers a more reliable method for identifying unknown specimens, contributing to the overall effectiveness of boll weevil research and control efforts.
Invasions and Local Outbreaks of Four Species of Plague Locusts in South Africa: A Historical Review of Outbreak Dynamics and Patterns
Authors: Price Roger Edward
Published: October 2023

The current paper provides a detailed review of the historical outbreaks of each of the four plague locust species found in South Africa, namely the brown locust, the African migratory locust, the red locust, and the southern African desert locust. The history and dynamics of the plague infestations and the major local outbreaks are summarized. The typical patterns of the outbreaks of the different species are described, and the threat of these locusts to agriculture in South Africa is defined. The brown locust produces regular outbreaks in the semi-arid Karoo, with large-scale eruptions of plague proportions occurring about once per decade. Patterns of outbreaks often repeat themselves, but the sheer size of the plague outbreaks is almost impossible to stop, and the brown locust has the potential to threaten food security throughout southern Africa. The African migratory locust produces outbreaks in some of the main maize and wheat cropping areas where it is difficult to control. This locust has taken advantage of the man-made crop environment to produce an extra generation per year that was not previously possible in the original grasslands. The coastal area of KwaZulu Natal Province in South Africa was a prime reception and breeding area for plague invasions of the red locust in the past, and the country, therefore, relies on the successful control of outbreaks in east and central Africa to prevent the recurrence of the plague invasions. The southern African desert locust occurs in the Kalahari Desert area, and outbreaks requiring chemical control are rare.
The Impact of Urbanization on Taxonomic Diversity and Functional Similarity among Butterfly Communities in Waterfront Green Spaces
Authors: Fang Wenqiang , Lin Xiaoqian , Lin Ying , Huang Shanjun , Huang Jingkai , Fan Shiyuan , Ran Chengyu , Dang Emily , Lin Yuxin , Fu Weicong
Published: October 2023

Urbanization has been shown to cause biodiversity loss. However, its effects on butterfly taxonomic and functional diversity still need to be studied, especially in urban waterfront green spaces where mechanisms of impact still need to be explored. We used butterflies as indicators to study how urbanization affects their taxonomic and functional diversity and identify indicator species in different urban ecological gradient areas. From July to September 2022, we surveyed 10 urban waterfront green spaces in Fuzhou City, China. We recorded 1163 butterflies of 28 species from 6 families. First, we explored the effects of urbanization on butterfly communities and made pairwise comparisons of different urban ecological gradients (α-diversity); secondly, we looked for differences between butterfly communities across urban ecological gradients (β-diversity); finally, we investigated differences in the response of butterfly functional groups to different urban ecological gradient areas and identified ecological indicative species. This study found the following: (1) Urbanization has led to the simplification of butterfly community structure, but there are also favorable factors that support the survival of individual butterflies; (2) Urbanization has led to significant differences in butterfly communities and plant-feeding polyphagous butterfly groups; (3) Urbanization has led to differences in the functional diversity of butterfly diet and activity space groups; (4) We identified five eco-indicator species in different urban ecological gradients.
Foraging Behaviors of Red Imported Fire Ants (Hymenoptera Formicidae) in Response to Bait Containing Different Concentrations of Fipronil, Abamectin, or Indoxacarb
Authors: Du Chengju , Lyu Hailong , Wang Lanfeng , Mao Lei , Li Lin , Yang Xinya , Wang Cai
Published: October 2023

The red imported fire ant, Solenopsis invicta Buren, is a severe pest with agricultural, ecological, and medical significance. The baiting treatment is one of the main methods to control S. invicta. However, few studies have evaluated the acceptance of fire ant bait. Here, field and laboratory studies were conducted to investigate the foraging behaviors of S. invicta responding to fire ant baits containing different concentrations of active ingredients (fipronil, abamectin, or indoxacarb). Field studies showed that S. invicta transported significantly less 0.0125% fipronil bait than control bait (without toxicant) and 0.0001% fipronil bait. The number of foraging ants significantly decreased with an increase in fipronil concentration. Our previous study showed that S. invicta usually buries the food treated with repellent chemicals, and interestingly, significantly more soil particles were transported into tubes containing 0.0001% fipronil bait than tubes containing control bait or 0.0125% fipronil bait. In addition, S. invicta transported significantly less 0.0005% abamectin bait than control bait, and significantly fewer ants were found in tubes containing 0.0125% abamectin bait than control bait. However, there was no significant difference in bait transport, number of foraging ants, and weight of soil particles relocated in tubes containing different concentrations of indoxacarb bait. In addition, laboratory studies showed that S. invicta transported significantly less 0.0125% fipronil bait than control bait and bait containing abamectin (0.0025% or 0.0125%) or indoxacarb (0.0125% or 0.0625%). In addition, the transport speed for the 0.0125% fipronil bait was the slowest. These results show that specific concentrations of some active ingredients may negatively affect bait acceptance for S. invicta, and should be avoided in fire ant bait production.
A Novel Internet of Things-Based System for Ten-Pin Bowling
Authors: Zosimadis Ilias , Stamelos Ioannis
Published: October 2023

Bowling is a target sport that is popular among all age groups with professionals and amateur players. Delivering an accurate and consistent bowling throw into the lane requires the incorporation of motion techniques. Consequently, this research presents a novel IoT Cloud-based system for providing real-time monitoring and coaching services to bowling athletes. The system includes two inertial measurement units (IMUs) sensors for capturing motion data, a mobile application, and a Cloud server for processing the data. First, the quality of each phase of a throw is assessed using a Dynamic Time Warping (DTW)-based algorithm. Second, an on-device-level technique is proposed to identify common bowling errors. Finally, an SVM classification model is employed for assessing the skill level of bowler athletes. We recruited nine right-handed bowlers to perform 50 throws wearing the two sensors and using the proposed system. The results of our experiments suggest that the proposed system can effectively and efficiently assess the quality of the throw, detect common bowling errors, and classify the skill level of the bowler.
Conduction System Pacing for Cardiac Resynchronization Therapy
Authors: Cano Óscar , Navarrete-Navarro Javier , Jover Pablo , Osca Joaquín , Izquierdo Maite , Navarro Josep , Ayala Hebert D. , Martínez-Dolz Luis
Published: October 2023

Cardiac resynchronization therapy (CRT) via biventricular pacing (BiVP-CRT) is considered a mainstay treatment for symptomatic heart failure patients with reduced ejection fraction and wide QRS. However, up to one-third of patients receiving BiVP-CRT are considered non-responders to the therapy. Multiple strategies have been proposed to maximize the percentage of CRT responders including two new physiological pacing modalities that have emerged in recent years: His bundle pacing (HBP) and left bundle branch area pacing (LBBAP). Both pacing techniques aim at restoring the normal electrical activation of the ventricles through the native conduction system in opposition to the cell-to-cell activation of conventional right ventricular myocardial pacing. Conduction system pacing (CSP), including both HBP and LBBAP, appears to be a promising pacing modality for delivering CRT and has proven to be safe and feasible in this particular setting. This article will review the current state of the art of CSP-based CRT, its limitations, and future directions.
The Evolution of Sinus Tarsi Syndrome—What Is the Underlying Pathology?—A Critical Review
Authors: Willegger Madeleine , Bouchard Maryse , Schwarz Gilbert M. , Hirtler Lena , Veljkovic Andrea
Published: October 2023

Background and Objectives: Sinus tarsi syndrome (STS) is defined as pain located at the lateral opening of the tarsal sinus. The exact etiology of sinus tarsi syndrome is not completely understood. Some do not believe it to be a true pathology. This review aims to clarify the definition of sinus tarsi syndrome to better understand the underlying pathologies. We further propose an algorithm to evaluate sinus tarsi pain and provide advice for consecutive treatment options. Design: This is a narrative review. By searching PubMed, the available current literature was reviewed. Articles were critically analyzed to determine the pathoanatomy, biomechanics, and etiology of sinus tarsi pain. Algorithms for clinical evaluation, diagnosis, and treatment were also recorded. Finally, the authors approach to evaluating and treating sinus tarsi pain was included in this review. Results: Reviewing the available literature, STS seems to be a catch-all phrase used to describe any pain in this anatomic region. Many causes of sinus tarsi pain were listed, including impingement, subtalar instability, and many other pathologies around the ankle. Conclusions: A thorough evaluation of patients presenting with pain in the sinus tarsi or instability of the hindfoot is essential to determining the underlying cause. When the cause of pain is still not clear after clinical exam and radiologic assessment, subtalar arthroscopy can be helpful as both a diagnostic and treatment tool. We propose that the term of STS should be avoided and that a more accurate diagnosis be used when possible. Once a diagnosis is made, appropriate treatment can be initiated.
Interaction Networks Explain Holoenzyme Allostery in Protein Kinase A
Authors: Welsh Colin L. , Conklin Abigail E. , Madan Lalima K.
Published: October 2023

Protein kinase A (PKA) signaling exemplifies phosphorylation-based signaling as we understand it today. Its catalytic-subunit structure and dynamics continue to advance our understanding of kinase mechanics as the first protein kinase catalytic domain to be identified, sequenced, cloned, and structurally detailed. The PKA holoenzyme elaborates on the role of its regulatory subunits and maintains our understanding of cAMP-dependent cellular signaling. The activation of PKA holoenzymes by cAMP is an example of specialized protein allostery, emphasizing the relevance of protein binding interfaces, unstructured regions, isoform diversity, and dynamics-based allostery. This review provides the most up-to-date overview of PKA structure and function, including a description of the catalytic and regulatory subunits’ structures. In addition, the structure, activation, and allostery of holoenzymes are covered.
A Methodological Proposal for the Design of Agricultural Parks—The Case of Metropolitan City of Rome
Authors: Cimini Angela , Giovanelli Giorgio , Marino Davide , Mazzocchi Giampiero , Pagano Giovanni
Published: October 2023

Urbanisation processes have led to the emergence of functional and formal hybrids, blurring and fragmenting the traditional boundaries between urban and rural areas. Agricultural parks have emerged as a planning tool to govern these hybrid areas between ‘countryside’ and the ‘city’, as well as to promote sustainable land use and community development. This paper, analysing the Metropolitan City of Rome (Italy) as a case study, illustrates an innovative pilot methodology for identifying the area of an Agricultural Park and, in particular, the area of the Rome Metropolitan Agricultural Park (MAP), a policy proposal for the metropolitan city. The aim of the article is twofold: to analyse the multifunctionality of farms in the periurban area of Rome to highlight the types of goods and services on which the relationship between farms and the metropolitan population is based and to expose the methodological path on which the MAP policy proposal was developed. A geospatial analysis, using the National Land Consumption Map (LCM) and the CORINE Land Cover (CLC), highlights the main agricultural areas and evaluates their quality. Isochronous curves assess the accessibility, and the GHS population grid (GHS-POP) defines the catchment areas. This approach, building on the 15 min city framework, has analysed the multifunctional farms and the types of goods and services offered to the population. A total of 91,656 hectares were identified as potential geographical areas of the Metropolitan Agricultural Park that could serve nearly 1 million inhabitants between rural and urban areas of Rome. The research highlights its characteristics in terms of the role of multifunctional farms, Alternative Food Networks, and the relationships between consumers and producers.
Modeling Soil Health Indicators to Assess the Effectiveness of Sustainable Soil Management on Mediterranean Arable Land
Authors: Piccini Chiara , Farina Roberta , Di Bene Claudia , Vanino Silvia , Napoli Rosario
Published: October 2023

Considering future tasks in soil health, resource management, and environmental protection, farmers are challenged to develop sustainable strategies for managing soil and land resources. In this study, the long-term sustainability of two fertilization strategies—current, with synthetic fertilizers (SYN) vs. conservative, with organic sources of nitrogen (organic amendments plus green manure with a legume, CONS)—was assessed in a processing tomato/durum wheat rotation. The EPIC model was used, validated with field data, and then run to simulate the management for 30 years under three current and future climates. Yield, soil organic carbon (SOC) stock change, nitrogen use efficiency (NUE), water use efficiency (WUE), and nitrate leaching were considered sustainability indicators. Under all of the future climate scenarios, tomato yield increased with CONS, remaining almost stable with SYN. Wheat yield increased both with CONS and SYN; however, the average yield with CONS was considerably lower than with SYN. NUE and nitrate leaching followed the same trend, both decreasing with CONS, while WUE was higher with CONS compared to SYN. The effect of CONS on SOC was always positive. Thus, the alternative N fertilization strategy proposed can be a favorable option for maintaining soil health and sustainable crop production.
Hidden Dangers: Herbal and Dietary Supplement Induced Hepatotoxicity
Authors: Lin Jonathan Kwong-Shing , Tujios Shannan R.
Published: October 2023

Herbal and dietary supplements represent a multi-billion-dollar industry reportedly used by over half of American adults. However, these products are not regulated by the Federal Drug Agency and contain a wide range of contaminants, leading to over 50,000 adverse events each year. This review aims to highlight the widespread use and current regulatory status of herbal and dietary supplements, identify the presentation and diagnostic dilemmas faced with liver injury, and discuss the most common agents implicated in herbal and dietary supplement hepatotoxicity.
Ultrahigh UV Responsivity Quasi-Two-Dimensional BixSn1−xO2 Films Achieved through Surface Reaction
Authors: Xu Zhihao , Xu Miao , Chen Fang , Zhai Rui , Wu You , Zhao Zhuan , Pan Shusheng
Published: October 2023

In this study, quasi-two-dimensional BixSn1−xO2 (BTO) thin films were fabricated using a liquid metal transfer method. The ultraviolet (UV) photodetector based on BTO thin films was constructed, and the ultrahigh responsivity of 589 A/W was observed at 300 nm UV light illumination. Interestingly, by dropping ethanol during light-off period, the recovery time induced by the persistent photoconductivity (PPC) effect is reduced from 1.65 × 103 s to 5.71 s. Furthermore, the recovery time can also be reduced by dropping methanol, propylene glycol, NaNO2, and Na2SO3 after light termination. The working mechanisms are attributed to the rapid consumption of holes stored in BTO thin films by reaction with those solutions. This work demonstrates that the BTO thin films have potential applications in high-performance UV detectors and present an innovation route to weaken the PPC effects in semiconductors by introducing chemical liquids on their surface.
Correction: Fati et al. Cyberbullying Detection on Twitter Using Deep Learning-Based Attention Mechanisms and Continuous Bag of Words Feature Extraction. Mathematics 2023, 11, 3567
Authors: Fati Suliman Mohamed , Muneer Amgad , Alwadain Ayed , Balogun Abdullateef O.
Published: October 2023

In the original paper [...]
The Effect of Asynchronous Grouting Pressure Distribution on Ultra-Large-Diameter Shield Tunnel Segmental Response
Authors: Wang Chen , Song Ming , Zhu Min , Chen Xiangsheng , Bao Xiaohua
Published: October 2023

The complex distribution of synchronous grouting pressure results in excessive tunnel deformation and various structural diseases, especially for ultra-large-diameter shield tunnels. In this study, to reduce the risk of tunnel failure, a three-dimensional refined finite element model was established for the Wuhan Lianghu highway tunnel project, taking into account the non-uniform distribution of synchronous grouting pressure. This study focuses on investigating the development patterns of internal forces, deformations, and damages in segment structures under varying grouting pressure ratios. The results indicate that the primary failure mode of a segment is tensile failure occurring at the outer edge of the arch. Moreover, an increased ratio of grouting pressure between the arch bottom and top leads to a higher positive bending moment value and greater tensile damage at the arch waist. The tunnel ring gradually exhibits distinct “horizontal duck egg” shape deformation. When the grouting pressure ratio is 2.8, there is a risk of tensile cracking at the outer edge of the arch waist. At this time, the segment convergence deformation is 39.71 mm, and the overall floating amount reaches 43.12 mm. This research offers engineering reference for the prediction of internal forces and deformations in ultra-large-diameter shield tunnels during grouting construction, thereby facilitating their application in the development of resilient cities.
A Synthetic Ultra-Wideband Transceiver for Millimeter-Wave Imaging Applications
Authors: Mirbeik Amir , Najafizadeh Laleh , Ebadi Negar
Published: October 2023

In this work, we present a transceiver front-end in SiGe BiCMOS technology that can provide an ultra-wide bandwidth of 100 GHz at millimeter-wave frequencies. The front-end utilizes an innovative arrangement to efficiently distribute broadband-generated pulses and coherently combine received pulses with minimal loss. This leads to the realization of a fully integrated ultra-high-resolution imaging chip for biomedical applications. We realized an ultra-wide imaging band-width of 100 GHz via the integration of two adjacent disjointed frequency sub-bands of 10–50 GHz and 50–110 GHz. The transceiver front-end is capable of both transmit (TX) and receive (RX) operations. This is a crucial component for a system that can be expanded by repeating a single unit cell in both the horizontal and vertical directions. The imaging elements were designed and fabricated in Global Foundry 130-nm SiGe 8XP process technology.
Patterning Techniques in Coplanar Micro/Nano Capacitive Sensors
Authors: Joo Seokwon , Han Jung Yeon , Seo Soonmin , Kim Ju-Hyung
Published: October 2023

Rapid technological advancements have led to increased demands for sensors. Hence, high performance suitable for next-generation technology is required. As sensing technology has numerous applications, various materials and patterning methods are used for sensor fabrication. This affects the characteristics and performance of sensors, and research centered specifically on these patterns is necessary for high integration and high performance of these devices. In this paper, we review the patterning techniques used in recently reported sensors, specifically the most widely used capacitive sensors, and their impact on sensor performance. Moreover, we introduce a method for increasing sensor performance through three-dimensional (3D) structures.
Electric Field Effects on Curved Graphene Quantum Dots
Authors: de-la-Huerta-Sainz Sergio , Ballesteros Angel , Cordero Nicolás A.
Published: October 2023

The recent and continuous research on graphene-based systems has opened their usage to a wide range of applications due to their exotic properties. In this paper, we have studied the effects of an electric field on curved graphene nanoflakes, employing the Density Functional Theory. Both mechanical and electronic analyses of the system have been made through its curvature energy, dipolar moment, and quantum regeneration times, with the intensity and direction of a perpendicular electric field and flake curvature as parameters. A stabilisation of non-planar geometries has been observed, as well as opposite behaviours for both classical and revival times with respect to the direction of the external field. Our results show that it is possible to modify regeneration times using curvature and electric fields at the same time. This fine control in regeneration times could allow for the study of new phenomena on graphene.
Exploring the Potential of GaN-Based Power HEMTs with Coherent Channel
Authors: Chen Xinghuan , Wang Fangzhou , Wang Zeheng , Huang Jing-Kai
Published: October 2023

The GaN industry always demands further improvement in the power transport capability of GaN-based high-energy mobility transistors (HEMT). This paper presents a novel enhancement-type GaN HEMT with high power transmission capability, which utilizes a coherent channel that can form a three-dimensional electron sea. The proposed device is investigated using the Silvaco simulation tool, which has been calibrated against experimental data. Numerical simulations prove that the proposed device has a very high on-state current above 3 A/mm, while the breakdown voltage (above 800 V) is not significantly affected. The calculated Johnson’s and Baliga’s figure-of-merits highlight the promise of using such a coherent channel for enhancing the performance of GaN HEMTs in power electronics applications.
Trap Characterization Techniques for GaN-Based HEMTs: A Critical Review
Authors: Zou Xiazhi , Yang Jiayi , Qiao Qifeng , Zou Xinbo , Chen Jiaxiang , Shi Yang , Ren Kailin
Published: October 2023

Gallium nitride (GaN) high-electron-mobility transistors (HEMTs) have been considered promising candidates for power devices due to their superior advantages of high current density, high breakdown voltage, high power density, and high-frequency operations. However, the development of GaN HEMTs has been constrained by stability and reliability issues related to traps. In this article, the locations and energy levels of traps in GaN HEMTs are summarized. Moreover, the characterization techniques for bulk traps and interface traps, whose characteristics and scopes are included as well, are reviewed and highlighted. Finally, the challenges in trap characterization techniques for GaN-based HEMTs are discussed to provide insights into the reliability assessment of GaN-based HEMTs.
Power Electronics Revolutionized: A Comprehensive Analysis of Emerging Wide and Ultrawide Bandgap Devices
Authors: Rafin S , Ahmed Roni , Haque Md. , Hossain Md. , Haque Md. , Mohammed Osama
Published: October 2023

This article provides a comprehensive review of wide and ultrawide bandgap power electronic semiconductor devices, comparing silicon (Si), silicon carbide (SiC), gallium nitride (GaN), and the emerging device diamond technology. Key parameters examined include bandgap, critical electric field, electron mobility, voltage/current ratings, switching frequency, and device packaging. The historical evolution of each material is traced from early research devices to current commercial offerings. Significant focus is given to SiC and GaN as they are now actively competing with Si devices in the market, enabled by their higher bandgaps. The paper details advancements in material growth, device architectures, reliability, and manufacturing that have allowed SiC and GaN adoption in electric vehicles, renewable energy, aerospace, and other applications requiring high power density, efficiency, and frequency operation. Performance enhancements over Si are quantified. However, the challenges associated with the advancements of these devices are also elaborately described: material availability, thermal management, gate drive design, electrical insulation, and electromagnetic interference. Alongside the cost reduction through improved manufacturing, material availability, thermal management, gate drive design, electrical insulation, and electromagnetic interference are critical hurdles of this technology. The review analyzes these issues and emerging solutions using advanced packaging, circuit integration, novel cooling techniques, and modeling. Overall, the manuscript provides a timely, rigorous examination of the state of the art in wide bandgap power semiconductors. It balances theoretical potential and practical limitations while assessing commercial readiness and mapping trajectories for further innovation. This article will benefit researchers and professionals advancing power electronic systems.
A Review on the Coalescence of Confined Drops with a Focus on Scaling Laws for the Growth of the Liquid Bridge
Authors: Ryu Sangjin , Zhang Haipeng , Anuta Udochukwu John
Published: October 2023

The surface–tension-driven coalescence of drops has been extensively studied because of the omnipresence of the phenomenon and its significance in various natural and engineering systems. When two drops come into contact, a liquid bridge is formed between them and then grows in its lateral dimensions. As a result, the two drops merge to become a bigger drop. The growth dynamics of the bridge are governed by a balance between the driving force and the viscous and inertial resistances of involved liquids, and it is usually represented by power–law scaling relations on the temporal evolution of the bridge dimension. Such scaling laws have been well-characterized for the coalescence of unconfined or freely suspended drops. However, drops are often confined by solid or liquid surfaces and thus are a different shape from spheres, which affects their coalescence dynamics. As such, the coalescence of confined drops poses more complicated interfacial fluid dynamics challenges compared to that of unconfined drops. Although there have been several studies on the coalescence of confined drops, they have not been systematically reviewed in terms of the properties and geometry of the confining surface. Thus, we aim to review the current literature on the coalescence of confined drops in three categories: drop coalescence on a solid surface, drop coalescence on a deformable surface, and drop coalescence between two parallel surfaces with a small gap (i.e., Hele-Shaw cell), with a focus on power–law scaling relations, and to suggest challenges and outlooks for future research on the phenomena.
A High-Performance InGaAs Vertical Electron–Hole Bilayer Tunnel Field Effect Transistor with P+-Pocket and InAlAs-Block
Authors: Liu Hu , Li Peifeng , Zhou Xiaoyu , Wang Pengyu , Li Yubin , Pan Lei , Zhang Wenting , Li Yao
Published: October 2023

To give consideration to both chip density and device performance, an In0.53Ga0.47As vertical electron–hole bilayer tunnel field effect transistor (EHBTFET) with a P+-pocket and an In0.52Al0.48As-block (VPB-EHBTFET) is introduced and systematically studied by TCAD simulation. The introduction of the P+-pocket can reduce the line tunneling distance, thereby enhancing the on-state current. This can also effectively address the challenge of forming a hole inversion layer in an undoped InGaAs channel during device fabrication. Moreover, the point tunneling can be significantly suppressed by the In0.52Al0.48As-block, resulting in a substantial decrease in the off-state current. By optimizing the width and doping concentration of the P+-pocket as well as the length and width of the In0.52Al0.48As-block, VPB-EHBTFET can obtain an off-state current of 1.83 × 10−19 A/μm, on-state current of 1.04 × 10−4 A/μm, and an average subthreshold swing of 5.5 mV/dec. Compared with traditional InGaAs vertical EHBTFET, the proposed VPB-EHBTFET has a three orders of magnitude decrease in the off-state current, about six times increase in the on-state current, 81.8% reduction in the average subthreshold swing, and stronger inhibitory ability on the drain-induced barrier-lowering effect (7.5 mV/V); these benefits enhance the practical application of EHBTFETs.
Smart-Data-Glove-Based Gesture Recognition for Amphibious Communication
Authors: Fan Liufeng , Zhang Zhan , Zhu Biao , Zuo Decheng , Yu Xintong , Wang Yiwei
Published: October 2023

This study has designed and developed a smart data glove based on five-channel flexible capacitive stretch sensors and a six-axis inertial measurement unit (IMU) to recognize 25 static hand gestures and ten dynamic hand gestures for amphibious communication. The five-channel flexible capacitive sensors are fabricated on a glove to capture finger motion data in order to recognize static hand gestures and integrated with six-axis IMU data to recognize dynamic gestures. This study also proposes a novel amphibious hierarchical gesture recognition (AHGR) model. This model can adaptively switch between large complex and lightweight gesture recognition models based on environmental changes to ensure gesture recognition accuracy and effectiveness. The large complex model is based on the proposed SqueezeNet-BiLSTM algorithm, specially designed for the land environment, which will use all the sensory data captured from the smart data glove to recognize dynamic gestures, achieving a recognition accuracy of 98.21%. The lightweight stochastic singular value decomposition (SVD)-optimized spectral clustering gesture recognition algorithm for underwater environments that will perform direct inference on the glove-end side can reach an accuracy of 98.35%. This study also proposes a domain separation network (DSN)-based gesture recognition transfer model that ensures a 94% recognition accuracy for new users and new glove devices.
Microfluidic Devices for Precision Nanoparticle Production
Authors: Bezelya Ayşenur , Küçüktürkmen Berrin , Bozkır Asuman
Published: October 2023

In recent years, the field of drug delivery has seen a significant shift towards the exploration and utilization of nanoparticles (NPs) as versatile carriers for therapeutic agents. With its ability to provide exact control over NPs’ characteristics, microfluidics has emerged as a potent platform for the efficient and controlled synthesis of NPs. Microfluidic devices designed for precise fluid manipulation at the micro-scale offer a unique platform for tailoring NP properties, enabling enhanced control over NP properties such as size, morphology, and size distribution while ensuring high batch-to-batch reproducibility. Microfluidics can be used to produce liposomes, solid lipid nanoparticles, polymer-based NPs, and lipid-polymer hybrid NPs, as well as a variety of inorganic NPs such as silica, metal, metal oxide, quantum dots, and carbon-based NPs, offering precise control over composition and surface properties. Its unique precision in tailoring NP properties holds great promise for advancing NP-based drug delivery systems in both clinical and industrial settings. Although challenges with large-scale production still remain, microfluidics offers a transformative approach to NP synthesis. In this review, starting from the historical development of microfluidic systems, the materials used to create the systems, microfabrication methods, and system components will be discussed in order to provide the reader with an overview of microfluidic systems. In the following, studies on the fabrication of nanoparticles such as lipid NPs, polymeric NPs, and inorganic NPs in microfluidic devices are included.
Changes in the Proliferation of the Neural Progenitor Cells of Adult Mice Chronically Infected with Toxoplasma gondii
Authors: Anaya-Martínez Verónica , Anacleto-Santos Jhony , Mondragón-Flores Ricardo , Zepeda-Rodríguez Armando , Casarrubias-Tabarez Brenda , de Jesús López-Pérez Teresa , de Alba-Alvarado Mariana Citlalli , Martínez-Ortiz-de-Montellano Cintli , Carrasco-Ramírez Elba , Rivera-Fernández Norma
Published: October 2023

During Toxoplasma gondii chronic infection, certain internal factors that trigger the proliferation of neural progenitor cells (NPCs), such as brain inflammation, cell death, and changes in cytokine levels, are observed. NPCs give rise to neuronal cell types in the adult brain of some mammals. NPCs are capable of dividing and differentiating into a restricted repertoire of neuronal and glial cell types. In this study, the proliferation of NPCs was evaluated in CD-1 adult male mice chronically infected with the T. gondii ME49 strain. Histological brain sections from the infected mice were evaluated in order to observe T. gondii tissue cysts. Sagittal and coronal sections from the subventricular zone of the lateral ventricles and from the subgranular zone of the hippocampal dentate gyrus, as well as sagittal sections from the rostral migratory stream, were obtained from infected and non-infected mice previously injected with bromodeoxyuridine (BrdU). A flotation immunofluorescence technique was used to identify BrdU+ NPC. The scanning of BrdU+ cells was conducted using a confocal microscope, and the counting was performed with ImageJ® software (version 1.48q). In all the evaluated zones from the infected mice, a significant proliferation of the NPCs was observed when compared with that of the control group. We concluded that chronic infection with T. gondii increased the proliferation of NPCs in the three evaluated zones. Regardless of the role these cells are playing, our results could be useful to better understand the pathogenesis of chronic toxoplasmosis.
Comparative Analysis of Rumen Microbiota Composition in Dairy Cows with Simple Indigestion and Healthy Cows
Authors: Wang Shuo , Kong Fanlin , Liu Jingjing , Xia Jianmin , Du Wen , Li Shengli , Wang Wei
Published: October 2023

Simple indigestion in cows leads to substantial economic losses in the dairy industry. Despite ongoing efforts, an effective treatment for this issue remains elusive. Previous studies have emphasized the vital role of rumen microbes in maintaining ruminant health. To deepen our comprehension of the intricate interplay between rumen microbiota and simple indigestion, we undertook a study involving the analysis of rumen fluid from eight cows with simple indigestion and ten healthy cows. Additionally, we collected data pertaining to milk production, rumination behavior, and rumen characteristics. The results showed that cows with simple indigestion displayed significantly lower milk yield, reduced rumination duration, and weakened rumen contraction when contrasted with the healthy cows (p < 0.05). However, no significant difference in microbiota α-diversity emerged (p > 0.05). Principal coordinate analysis (PCoA) illuminated substantial variations in rumen microbial structure among the two groups (p < 0.05). Further analysis spotlighted distinctive bacteria in the rumen of the cows with indigestion, including Allisonella, Synergistes, Megasphaera, Clostridium_XIVb, Campylobacter, and Acidaminococcus. In contrast, Coraliomargarita, Syntrophococcus, and Coprococcus are the dominant bacterial genera in the rumen of healthy dairy cows. Importantly, these key bacterial genera also dominated the overarching microbial interaction network. The observation suggests that changes in the abundance of these dominant bacterial genera potentially underlie the principal etiology of cows with simple indigestion. The present findings can provide insights into simple indigestion prevention and treatment in dairy cows.