bluuebunny/crossref_metadata_2025 huggingface dataset:
Honorary Decrees from Ephesos for Winning Athletes in Panhellenic Games
Authors: Dardano Valentina , Di Grazia Mariangela , Mander Barbara , Tentori Montalto Marco
Published: July 2021

A marble block from Ephesos bears the text of three honorary decrees dating back to 300 B.C. ca. According to the inscriptions, the city council granted citizenship and prize money to young athletes who distinguished themselves in prestigious panhellenic games. The main figure in the second inscription, Athenodoros, ἰσοτελής in Ephesos before being granted citizenship, is mentioned in I.Ephesos 2005. On the occasion of this decree, his talent earned him a subvention from the city; a similar grant might have been assigned to another rising athlete, Timonax, referred to in the third inscription.
Grant of Prominent Individuals for the Restoration of a Gymnasium in Larissa
Authors: Micaletti Vincenzo
Published: July 2021

Philip V king of Macedon and his son Perseus are recorded on a list as prominent individuals for the restoration of a gymnasium in Larissa, as a result of the new scenario after the Second Macedonian War. The decree (first quarter of II century BC) concerns the epidosis of local nobles and in general the euergetism of Hellenistic kings.
Analysis of the Pancreas Functional Capacity at the Comorbidity of Chronic Pancreatitis with Diabetes Mellitus Type 2
Authors: Babynets Liliia , Sasyk Halyna
Published: July 2021

The diagnosis, treatment and rehabilitation of patients with chronic pancreatitis (CP) with concomitant diabetes mellitus (DM), whose incidence is increasing.

The objective: was to investigate the state of functional capacity of the pancreas in patients with comorbidity of chronic pancreatitis and diabetes type 2.

Materials and methods. 137 patients with CP with and without concomitant diabetes mellitus were studied: the main group consisted of 112 outpatients with CP in combination with diabetes mellitus in the phase of stable or unstable remission, the comparison group – 25 patients with isolated CP, and the control group – 30 healthy individuals. Verification of diagnoses and determination of the pancreas functional capacity parameters was carried out according to generally accepted world standards.

Results. In comorbidity, exocrine insufficiency (ExI) was significantly more severe than in the group of patients with isolated CP in the content of fecal α-elastase, which corresponded to the medium and mild degrees of ExI respectively, and the coprogram score – respectively (5,60±0,10) and (3,89±0,16) points (p<0,05). We found a significant predominance of patients with comorbidity relative to that with an isolated course of CP among those who had mild (22,6 % vs. 11,7 %) and moderate (50,1 % vs. 3,7 %) degree of ExI in the complete absence of severe pancreas ExI in isolated CP against 5.1 % of such patients with CP and diabetes mellitus type 2. A statistically significant higher content of HbA1c in patients with CP with concomitant diabetes was found in relation to the group of patients with isolated CP (7,71±0,16 % vs. (5,66±0,10 %), glucose – respectively (28,89±0,33 mmol/l against 5,27±0,11 mmol/l), the level of the HOMA index – 3,29±0,07 against 1,63±0,09 (p<0,05), which confirmed the presence of IR in patients with pancreas endocrine insufficiency in the cohort of subjects, and also proved that these patients have diabetes type 2. Evaluation of the ultrasound score of the structure of the software proved that in comorbidity with diabetes mellitus, this figure is higher and corresponds to a severe degree, while in isolated CP of the studied patients – the average severity (6,25±0,67) points against (3,89±0,78) points.

Conclusion. The distribution by index and severity of patients acording M-ANNHEIM in points statistically significantly proved that the comorbidity of CP and diabetes mellitus was dominated by patients with moderate (72,2 % vs. 24,0 %) and severe CP severity (17,0 % against 8,0 %), and in isolated CP – dominated by patients with moderate severity (64,0 % vs. 4,5 %), patients with severe were more in the group of comorbid patients (6,3 % vs. 4,0 %).
Pregnancy-related liver pathology: hyperemesis gravidarum, cholestatic hepatosis of pregnancy, preeclampsia/eclampsia, HELLP-syndrome, acute fatty liver of pregnancy
Authors: Golyanovskiy О.V. , Geints N.E.  , Mekhedko V.V.  , Frolov S.V. 
Published: July 2021

Liver disease associated with pregnancy affects up to 3% of women and is a common cause of dysfunction during pregnancy. Severe liver dysfunction is associated with high rates of maternal and infant morbidity and mortality.Therefore, it is important to know about liver diseases the woman suffered before pregnancy in order to adequately manage the pregnancy and reduce the number of complications during delivery. Research and recent advances in medicine tend to improve the consequences, but so far they have not shown significant reduction of the maternal and perinatal morbidity rates against the background of this pathology. Liver diseases that are characteristic for pregnancy can be classified into those of early pregnancy (hyperemesis gravidarum) and those of late pregnancy (preeclampsia/eclampsia, intrahepatic cholestasis of pregnant women; hemolysis, increased activity of liver enzymes) HELLP-syndrome, acute fatty liver disease of pregnant women - AFLP, liver rupture / infarction).The results of modern studies used in the practice of medical care for pregnant women with concomitant pathology have significantly improved the pregnancy and delivery outcomes, but the number of complications among the mother and the fetus is still high. In this article, we offer an overview of liver diseases complicated by pregnancy with a detailed presentation of their aetiology, pathogenesis, diagnosis, and treatment. The risk groups of pregnant women with the potential possibility of liver dysfunction development have also been identified.
Experience with alternative therapies in women with menopausal metabolic syndrome
Authors: Stefanovskaya O.V.  , Akker L.V. , Galchenko A.I. 
Published: July 2021

You study the influence of alternative therapies drug «Klimadynon®» in menopausal’nym patients with metabolic syndrome in the climacteric syndrome, weight, blood pressure, carbohydrate and lipid metabolism. Surveyed 38 patients aged 45 to 61 years (mean age 53,6±0,6 years) who were in natural menopause and had a series of violations within the framework of the metabolic syndrome (excess weight or obesity on abdominal’nomu type 2, type IMD dislipidemiu, arterial hypertension). Correction for climacteric disorders has been appointed an alternate method of treatment – «Klimadynon®» to 1 tablet 2 times daily. Estimated climacteric syndrome using modified menopausal index (E.V. Uvarova, 1983), carbohydrate, lipid Exchange, anthropometric parameters, level of HELL originally, after 3 and 6 months of initiating treatment. Against the backdrop of the reception of an alternative method of treatment with «Klimadynon®» we got the better of menopausal syndrome: in 13,3 % of heavy gravity menopausal syndrome has moved to middle level, in 52,6 % of the average degree of menopausal syndrome has moved into easy. Accurately noted improvements in the level of blood sugar on an empty stomach, reducing insulinorezisten- tnosti in women with menopausal’nym metabolic syndrome with therapy. «Klimadynon®» anticonvulsant therapy has statistically significant antiaterogennomu shift indicator of lipid Exchange in women. A tendency towards lower body mass index, waist, blood pressure. Thus, the application of the «Klimadynon®» in women with abnormal klimaksom and menopausal’nym metabolic syndrome could be a good option alternative therapies and significantly improve their quality of life.
Efficacy of Mastodinone® for mastalgia correction in pre- and perimenopausal women
Authors: Rozhkova N.I. , Burdina I.I. , Zapirova S.B. , Mazo M.L. , Prokopenko S.P. , Yakobs O.E.
Published: July 2021

The purpose of the study wasto examine the effectiveness of the drug Mastodynon® for the treatment of mastopathy in pre- and perimenopausal women.Materials and methods. The research was carried out within 12 months. Patient presenting complaints of pain in the breast, passed a comprehensive examination (clinical and Х-ray and/or sonographic) and questionnaires at the first visit and every 6 months. The plant-based drug Mastodynon®.Results. We examined 38 patients aged 45–56 years. Most women in this group for many years were observed due to mastopathy of different forms and degrees of severity. After 6 months after start of treatment with Mastodynon® the majority of patients reported decrease or absence of pain in the breasts, improvement of psycho-emotional condition. The positive effect of various degree was observed in 71,05% of the patients. After 1 year revealed a stabilization of the therapeutic effect of the drug Mastodynon® in 83,3% of cases. Mastodynon® has shown high effectiveness, good tolerability in the treatment of mastopathy in women of pre- and perimenopausal age, it has improved thepatients quality of life.
Possibilities of using xylitol and L-arginine drugs in menopause management
Authors: Lakhno I.V.
Published: July 2021

Menopause is accompanied by the development of a complex of disorders leading to the onset of metabolic syndrome X. In the pathogenesis of these disorders, hypoestrogenemia and hyperandrogenaemia play a significant role, which cause obesity, dyslipidemia, and type 2 diabetes mellitus. Adipose tissue is a «field» for the synthesis of mediators of chronic inflammation and oxidative stress. Unfortunately, hormone replacement therapy is not recognized as an intervention for preventing metabolic disorders. Since metabolic disorders reduce the duration of the period of working capacity and life in general, it is necessary to develop a management program focused on preventing or reducing their negative impact on the woman’s well-being. Xylitol is known as an energy-balancing agent with excellent anticatabolic effects. Recently, it was found that xylitol levels can be used to predict the prospects for weight loss without surgery in morbid obesity patients. The normalization of endothelial function is one of the key tasks in the management of menopausal women. It has been proven that a decrease in the level of nitric oxide in women of transitional age causes the development of vasculopathy. Since L-arginine is a substrate for the synthesis of nitric oxide, the use of its preparations is a promising option for women receiving hormone replacement therapy. The development of a therapeutic and prophylactic strategy using hormone replacement therapy, well-balanced physical activity, diet therapy and the use of xylitol and L-arginine preparations can become a reserve for improving the quality of life of women aged over 45. Possible criteria for assessment the effectiveness of a treatment program designed for six months are blood pressure, body mass index, blood glucose, HOMA index, lipid profile, micronutritients levels, as well as an assessment on the Kuperman scale.
The level of adhesion molecules in polycystic ovary syndrome
Authors: Mogylnytska L.A.
Published: July 2021

Polycystic ovary syndrome (PCOS) is characterized by dysfunction of the ovaries, hyperandrogenism and combination of metabolic disorders that increase the risk of developing cardiovascular diseases.The objective: of the investigation was to study the serum level of adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in women with PCOS with different body weights as a marker of endothelial dysfunction, and their relationship with other factors of cardiovascular pathology.Materials and methods. 45 women with PCOS were examined, among whom a group of obese people – 23 women (age: 22,82±3,03 years, BMI 35,67±4,6) and a non-obese – 22 women (age: 22,81±2,03 years, BMI 22,35±2,16). The control group included 20 women aged 20,15±2,15 years, BMI 21,32±2,19. The serum level of ICAM-1, VCAM-1 and E-selectin was determined by the enzyme immunoassay. The significance of the differences of mean values was determined by the Student’s t-test. Correlation and multivariate regression analysis was used to assess the relationship between the studied factors,.Results. We revealed a significant increase of the serum level of adhesion molecules in obese and non-obese women with PCOS in comparison with women in the control group: ICAM-1 – +54,18%, +36,72%, respectively (p<0,0001), VCAM-1 – +50,76%, +36,33% respectively (p<0,0001), E-selectin – +40,24%, +29,56% respectively (p<0,0001). The concentration of these factors was higher in obese women with PCOS compared to non-obese women with PCOS: ICAM-I – +12,76% (p=0,04), VCAM-1 – +10,58% (p=0,009), E-selectin – +8,24% (p=0,03); p<0,05. The relationship was established between insulin content, HOMA and Caro index, lipid metabolism, hyperandrogenemia and an increase of serum level of adhesion molecules (p<0,01).Conclusions. As a result of our study, an increase of serum level of adhesion molecules in PCOS was revealed, both in combination with obesity and normal body weight, which may be a manifestation of endothelial dysfunction in this pathological condition. An increase in the content of ICAM-1, VCAM-1, E-selectin may be associated with insulin resistance, dyslipidemia and hyperandrogenism.
Complex clinical and echographic assessment of the peculiarities of developmental anomalies of uterus and vagina in children and adolescents
Authors: Sadoviy A. P.
Published: July 2021

The objective. To assess the structure of independent and combined forms of anomalies in the development of the uterus and/or vagina in children and adolescents, justifying the need for ultrasound screening in this age group.Materials and methods. The study involved 146 patients with malformations of the uterus and/or vagina at the age from 10 to 20 years. All patients underwent a clinical examination, which included anamnestic data, gynecological examination, and ultrasound examination. The calculation of indicators of the diagnostic information content of ultrasound was carried out taking into account the sensitivity, specificity and accuracy of the method.Results. In the course of the study, it was found that the largest proportion of all anomalies of the internal genitals was uterine malformations (37,0%), complete doubling of the uterus and vagina (17,1%), vaginal aplasia (15,1%). Genetic or chromosomal pathology was detected in 36 patients (24,7%), in the remaining 110 patients (75,3%) a multifactorial nature of the disease was assumed.Attention is drawn to the fact that 48 patients (32.8%) with uterine and/or vaginal malformations, who did not present complaints, were identified during the primary ultrasound screening, which indicates the effectiveness of this method in examining girls and adolescents. In 12 children (8,25%) in addition to abnormalities in the development of the uterus and/or vagina, ultrasound revealed tumors and tumor-like diseases of the uterine appendages. Also, 57 malformations of other organs and systems were revealed in 49 (33,6%) examined patients, and 8 (5,5%) had concomitant defects. In most cases, in 99 patients (67,8%) with anomalies in the development of internal genitalia, the anamnesis was aggravated by the factors of their parents (burdened heredity, disease, occupational health, etc.)Conclusion. As a result of a comprehensive clinical examination of patients with congenital anomalies in the development of internal genitalia, the diagnosis was clarified, the share of hereditary and some environmental factors in the manifestation of this pathology was revealed, which is one of the common gynecological diseases that are characterized by a variety of forms of anomalies, clinical symptoms and a high percentage of diagnostic errors. At puberty, the use of echography to clarify the state of the internal genital organs is of great practical importance. Non-invasiveness, absence of psychogenic traumatization, safety and high information content make it possible not only to diagnose congenital pathology, but also to use this method as a dynamic observation of the state of the uterus and/or vagina in girls and adolescents, which is very important when choosing rational methods for correcting this pathology
Determination of Arbutin in Herbal Medicinal Products
Authors: Antonova N. P. , Prokhvatilova S. S. , Shefer E. P. , Kalinin A. M. , Morgunov I. M. , Golomazova T. A. , Legon’kova U. S.
Published: July 2021

Arbutin is the main active ingredient in many herbal medicinal products that have diuretic, antimicrobial, bactericidal, and antioxidant effects. Many of these products are mixtures of different herbal substances. Therefore, the approaches to quality control of HMPs can vary significantly.

The aim of the study was to compare arbutin assay procedures used in quality control of arbutin-containing products.

Materials and methods. Samples of the following HMPs were used in the study: monocomponent Bearberry Leaf and multicomponent Brusniver® (herbal mixture, powder). The test methods used were titrimetry, ultraviolet-visible spectrophotometry, and high-performance liquid chromatography (HPLC).

Results. The authors compared five arbutin assay procedures described in the monographs and product files for arbutin-containing HMPs.

Conclusions. It has been established that the analysed procedures cannot be used interchangeably as equivalent test methods; the limits for arbutin have to be established for each specific procedure. Iodometric titration is the most labour- and time-consuming method, and the determined titration endpoint is a subjective assessment. Spectrophotometric methods do not require the use of an arbutin reference standard, but they can give overestimated results as compared to the HPLC and titrimetry methods. HPLC methods are more selective, but they require the use of reference standards. The recommended test methods for HMP quality control are HPLC and visible spectrophotometry; the titrimetric method is recommended for replacement.
Stability of Ready-to-Use and Laboratory-Prepared Culture Media
Authors: Kuleshova S. I. , Protsak S. A. , Lisunova S. A. , Romanyuk G. Yu.
Published: July 2021

The culture media quality, which depends to a large extent on growth promotion properties, determines the reliability and accuracy of test results obtained by microbiological methods. The procedure for culture media preparation is quite labourconsuming and includes several stages: successive dissolution of components exactly as specified in the recipe (qualitative and quantitative composition), sterilisation, adjusting the pH of the medium, and testing of growth promotion properties—therefore it is important to demonstrate the stability of each particular culture medium.

The aim of the study was to evaluate growth promotion properties of the culture media prepared in the laboratory from a dry mixture, and to assess their stability during long-term storage.

Materials and methods: stability testing was performed for fluid thioglycollate medium (FTM) and soybean-casein digest broth (SCD) prepared in the laboratory. FTM growth promotion properties were tested  using the following test microorganisms: Bacillus subtilis ATCC 6633,  Clostridium sporogenes ATCC 19404, Pseudomonas aeruginosa ATCC 9027,  Staphylococcus aureus ATCC 6538. SCD growth promotion properties were  tested using: Aspergillus brasiliensis ATCC 16404, Candida albicans ATCC  10231, Bacillus subtilis ATCC 6633. The stability study was carried out for 6  months, assessing changes in appearance and growth promotion properties. The test media were stored at room temperature and in a refrigerator at 2–8 °C.

Results: no growth of the anaerobic microorganism Clostridium sporogenes was observed in FTM after 3 months, regardless of storage conditions. Later on, there was no growth of the gram-positive microorganisms Bacillus subtilis and Staphylococcus aureus, which are more sensitive to the storage conditions than Pseudomonas aeruginosa. The growth promotion properties of the SCD prepared in the laboratory did not change during 6 months of storage.

Conclusions: FTM prepared from a dry mixture remains stable and retains its growth promotion properties for no more than two months when stored in a refrigerator at 2–8 °C. SCD can remain stable for 6 months, both at room temperature and when stored in the refrigerator.
Calculation of the Median Lethal Dose and Low Lethal Dose Using the CombiStats Biometric Software
Authors: Shadrin P. V. , Batuashvili T. A. , Simutenko L. V. , Neugodova N. P.
Published: July 2021

The median lethal dose (LD50) and low lethal dose (LD10) are calculated in acute toxicity studies, as well as during specific activity assessment of some medicines. The aim of the study was to develop a procedure for using CombiStats to calculate LD50 and LD10. The authors proposed a step-by-step algorithm for processing bioassay results using the CombiStats biometric software (median effective dose determination model, probit analysis) with conversion of doses to simple fractions (fractions of the maximum dose) to calculate LD50 and LD10. They compared LD50 and LD10 calculation results obtained using CombiStats with those obtained using electronic spreadsheets according to the Bliss–Miller–Tainter–Prozorovsky method described in the State Pharmacopoeia of the Russian Federation (General Monograph 1.1.0014.15). It has been demonstrated that the use of CombiStats sometimes has advantages over the use of the pharmacoepoeial method.
Genetic diversity in wild species and cultivars of strawberry for the FanAAMT gene controlling fruit flavor volatiles
Authors: Lyzhin A. S. , Luk’yanchuk I. V.
Published: July 2021

Background. An important consumer trait of strawberry fruits is their aroma. Methyl anthranilate makes a considerable contribution to the fruit flavor. The methyl anthranilate content in strawberry fruits is controlled by the FanAAMT (аnthranilic acid methyltransferase) gene. Identification of genetic determinants for this trait facilitates targeted selection of promising forms based on diagnostic DNA markers. The purpose of this study was to study the allelic diversity of the FanAAMT fruit flavor gene in wild strawberry species and strawberry cultivars for identification of promising genotypes.Materials and methods. The objects of this study were wild species of Fragaria L. as well as F. × anaschata Kantor. and F. × ananassa Duch. cultivars of different ecogeographic origin. The FanAAMT gene was identified with the dominant marker FanAAMT.Results and conclusion. In the analyzed collection of strawberry genotypes, the FanAAMT gene was identified in 36.4% of the forms, including the wild species F. vesca L., F. moschata Duch. and F. virginiana subsp. platypetala (Rydb.) Staudt, and cv. ‘Kupchikha’ (F. × anaschata). Among the analyzed F. × ananassa cultivars, the FanAAMT gene was found in 31.6% of the tested forms, specifically in 27.3% of the 22 Russian cultivars, and 37.5% of the analyzed foreign ones. Promising sources of high methyl anthranilate content in fruits were identified: wild spp. F. moschata, F. vesca, and F. virginiana subsp. platypetala; cv. ‘Kupchikha’ (F. × anaschata); Russian garden strawberry cvs. ‘Bylinnaya’, ‘Zenit’, ‘Lastochka’, ‘Neznakomka’, ‘Feyerverk’ and ‘Tsarskoselskaya’; and foreign garden strawberry cvs. ‘Karmen’, ‘Ostara’, ‘Samson’, ‘Symphony’, ‘Troubadour’ and ‘Vima Tarda’, in which the functional allele of the FanAAMT gene was found. In the remaining studied strawberry genotypes the marker FanAAMT was not detected, which presumably indicates that the FanAAMT gene is absent. cells (R9.4.1).
Sulu ve Kuru Tarım Alanlarında Buğday Verim Tahmininde Bitki Örtüsü İndekslerinin Kullanımı
Authors: KAYA Yunus , POLAT Nizar
Published: July 2021

Dünya nüfusunun artmasına paralel olarak tarım alanlarına olan ihtiyaç da artmaktadır. Son yıllarda tarım alanlarının ve bitki gelişiminin izlenmesi için geleneksel ve modern yöntemler sıklıkla kullanılmaktadır. Bu çalışmada çok zamanlı uydu görüntülerinden elde edilen bitki örtüsü indeksleri yardımıyla buğday bitkisinin fenolojik evreleri incelenmiş ve bitki örtüsü indeksleri ile verim değerleri kullanılarak verim tahmin modeli geliştirilmiştir. Çalışmada Şanlıurfa ilinde bulunan Tarım İşletmeleri Genel Müdürlüğü (TİGEM) arazisinde bulunan buğday tarlalarından sulu tarım ve kuru tarım yapılan tarlalardan 5’er tane seçilmiştir. 2015-2016, 2016-2017 ve 2017-2018 sezonlarına ait ekim ile hasat tarihleri arasında belirli zaman aralıklarında alınan Landsat-8 ve Sentinel-2 uydu görüntülerinden üretilen NDVI ve SAVI indeksleri yardımıyla buğday bitkisinin gelişim süreçleri incelenmiştir. Ayrıca 3 yıla ilişkin NDVI, SAVI, GNDVI ve MSAVI değerleri ile TİGEM’den temin edilen verim değerleri birlikte değerlendirilerek verim tahmin modeli kurulmuştur. Oluşturulan model 2018-2019 sezonunda hem sulu hem de kuru tarlalarda uygulanarak doğruluk analizi yapılmıştır. Sonuçlar incelendiğinde elde edilen modelin sulu tarlalarda kuru tarlalara oranda daha yüksek başarı gösterdiği görülmüştür. Ayrıca hem sulu tarlada hem de kuru tarlada elde edilen model %80 in üzerinde bir doğruluk göstermiştir.
2,4-D Diklorofenoksi Asetik Asit Maruziyeti Sonrasında Gökkuşağı Alabalıklarında (Oncorhynchus mykiss) Bazı Hematolojik ve Biyokimyasal Değişimlerin Belirlenmesi
Authors: KARADAS Naime Filiz , PARLAK Veysel , ATAMANALP Muhammed
Published: July 2021

2,4-D diklorofenoksi asetik asit (2,4-D) dünya genelinde yaygın olarak kullanılmakta olan bir herbisit olup, tarımsal mücadelede yabani otları elimine etmekte kullanılır. 2,4-D ve formlarının balıklar üzerinde yarattığı toksik etki diğer sucul canlılar üzerinde oluşan toksik etkiden bir hayli fazladır. Bu çalışmada 2,4-D Diklorofenoksi asetik asit herbisitinin gökkuşağı alabalığının (Oncorhynchus mykiss) biyokimyasal ve hematolojik parametreler üzerine etkisi araştırılmıştır. Uygulama sonrasında zamana bağlı olarak enzim parametrelerinde (MDA, GPx, SOD, CAT) artış belirlenirken doz, zaman ve doz x zaman interaksiyonlarının etkileri ise çok önemli bulunmuştur (p
Kahramanmaraş Ekolojik Şartlarında Karadutun (Urmu dut) Morfolojik, Fenolojik ve Pomolojik Özelliklerinin Belirlenmesi
Authors: SÜTYEMEZ Mehmet
Published: July 2021

Bu çalışma, Kahramanmaraş ilinde doğal olarak yetişen karadut (Morus nigra L., urmu dut) genotipi ve bu genotipten doku kültürü ile çoğaltılmış bitkilerin (5 bitki) morfolojik, fenolojik ve pomolojik özelliklerinin belirlenmesi amacıyla yapılmıştır.

Klonal bitkilere ait morfolojik ölçümlerde ortalama gövde yüksekliklerinin 77-89 cm, gövde kalınlıklarının 36-52.6 cm taç yüksekliklerinin 162.3-267.6 cm, taç genişliklerinin (çevre) 8.63.6-1263.3 cm arasında değiştiği belirlenmiştir. Yaprak ayası eninin 12.89-12.99 cm, yaprak boyunun 12.22-12.66 cm, yaprak sap uzunluklarının 2.48-2.66 mm ve yaprak sap kalınlığına ait ortalama değerlerin ise 2.71-2.99 mm arasında değiştiği tespit edilmiştir. Ebeveyn bitkide ise bu özelliklere ait değerlerin sırasıyla 12.96 cm, 12.61 cm, 2.61 mm, 2.77 mm olduğu belirlenmiştir.

Ana genotip dahil tüm bitkilerde tomurcuklar 4-6 Nisan döneminde patlarken, çiçek salkımlarının 9-13 Nisan döneminde görülmeye başladığı gözlenmiştir. Hasat dönemlerinin ise 20 Mayısta başlayıp Ağustos 25’e kadar devam ettiği belirlenmiştir.

Ebevyene ait meyve ağırlıklarının ortalaması 3.65 g olarak hesaplanmıştır. Klon bitkilerde ise ortalama meyve ağırlıkları 3.28g ile 3.96 g değerleri arasında bulunmuştur. Meyve örneklerinde yapılan diğer ölçümlerde ortalama pH %3.36-3.44, SÇKM %15.20-15.97, TEA değerlerinin ise %0.22-0.24 arasında değiştiği belirlenmiştir. Kuru maddenin %18.10-18.92, kül miktarının %3.15-3.25, protein oranının %3.19-3.92, ham yağın %4.96-5.72, toplam şekerin ise %14.81-15.44 arasında değiştiği belirlenmiştir. Renk değerlerinin L:18.47-18.97, a:5.11-5.72, b:5.83-5.93 arasında değiştiği bulunmuştur.

Genel olarak değerlendirildiğinde doku kültürü ile çoğaltılmış bitkiler ile ana ebeveyn bitki arasında bitkisel özellikler ve pomolojik özelliklerin çok yakın değerlere sahip olduğu görülmüştür.
Ereğli-Bor Alt Havzasında Arazi Kullanımı/Örtüsü'nün Uzaktan Algılama Yöntemleriyle Zamansal Değişimi
Authors: AYDIN Taha Kağan , DURDURAN Süleyman Savaş
Published: July 2021

Dünyamız hızlı nüfus artışı, doğal ve yapay etkenler neticesinde çeşitli çevresel etkiler altında kalmış ve zarar görmeye başlamıştır. Doğaya olan tahribatı en aza indirerek gelecek nesillere daha sağlıklı ve sürdürülebilir bir yaşam sunabilmek adına arazi kullanımı/örtüsü’nün zamansal değişimlerini incelemek ve gerekli tedbirlerin alınması esastır. Bu çalışmada Konya Ereğli-Bor Alt havzasının 1985-2018 yıllarını kapsayan 34 yıllık zaman diliminde arazi kullanımı/örtüsü üzerinde meydana gelen değişim, uzaktan algılama teknikleriyle detaylı şekilde incelenmiştir. Landsat TM uydu sistemlerinden temin edilen 1985 yılı ve 2018 yılı Ağustos ayına ait görüntüler ile CORİNE sınıflandırma sistemlerinden temin edilen 1990 yılı ve 2018 yılı arazi örtüsü verileri entegre edilerek 5 temel sınıfta eğitim alanları belirlenmiş ve Erdas imagine programı üzerinde Piksel Tabanlı Kontrollü sınıflandırma yapılmıştır. Sınıflandırma sonuçlarının doğruluğunu arttırmak adına her bir sınıf kendi içinde maskeleme yöntemi ile sınıflandırılmış işlem sonunda Birleştirme/bindirme Tekniği (Overlay) ile çalışma bölgesi birleştirilmiştir. Sınıflandırma sonucunda doğruluk analizleri ve kappa istatistikleri ile yapılan sınıflandırmanın doğruluğu teyit edilmiştir. Sınıflandırma işlemi sonucunda her iki yıl arasında Değişim analizi (Change Detection Analysis-Post Classification) yapılmıştır. Yapılan analiz sonuçlarına göre 1985 yılı sınıflandırma doğrulu %98, kappa istatistiği 0,97, 2018 yılı sınıflandırma doğruluğu %97 ve kappa istatistiği 0,95 olarak elde edilmiştir. Değişim analizi sonuçlarına göre 34 yıllık zaman diliminde mera alanlarında 7704 ha, tarım alanlarında 8401 ha, yapay bölgelerde 14735 ha’lık bir artış, orman alanlarında 27496 ha ve sulak alanlarda 3344 ha’lık bir azalış tespit edilmiştir.
Using Digital Newspaper as Creative Learning Media to Boost Students’ Higher Thinking Skills
Authors: Pentury Helda Jolanda , Anggraeni Anastasia Dewi
Published: July 2021

Through creative pedagogical application currently, the concepts of pedagogical strategy which are more technologically oriented than they used to be, transform education into a way where creative and innovative students’ perspectives and motivation are nurtured. Digital Newspaper concept of alignment, which expresses from social science and humanity has been developed useful in creating innovative and skillful academic environments, as it apply to integrate learning with cognitive, kinesthetic, technological, and social-culture aspects learning form.  The research conducted by observing students' projects and reveals the way they identify, classify, analyze and create creative learning from the topics of Jakarta Post online content as a learning media. The result of this study shows that using this media which has various current materials can increase students’ higher thinking critically, creatively and innovatively in English language learning. We recommend that in future research, researchers use more online newspaper which is more engaging with the real-world and give positive impact to boost students’ high order thinking skills to solve the problem, to analyze, and to make decisions in their English language performances.

 

Keywords: Creative Media, Language Skills, Thinking Skills
RANCANG BANGUN APLIKASI E-LIBRARY FAKULTAS TEKNIK UNIVERSITAS MUHAMMADIYAH TANGERANG
Authors: Maulana Syepry , Azhari Lukman , Taufiq Rohmat , Rahma Atika
Published: July 2021

Aplikasi e-Library Fakultas Teknik adalah sebuah aplikasi yang digunakan untuk membantu bagian Perpustakaan melakukan pengelolaan data dan transaksi pada Perpustakaan Fakultas Teknik Universitas Muhammadiyah Tangerang. Aplikasi ini digunakan oleh petugas agar lebih mudah dalam melakukan pencatatan peminjaman dan pengembalian buku dalam memantau buku yang tersedia dan dipinjam. Aplikasi ini dibuat dengan menggunakan metode pengembangan sistem Software Development Life Cycle (SDLC) dengan model Rapid Application Development (RAD). Pembangunan aplikasi ini berupa aplikasi Android yang dapat diakses oleh anggota perpustakaan dan terhubung dengan aplikasi Website yang diakses oleh petugas perpustakaan. Aplikasi angroid dibangun menggunakan Bahasa pemrograman PHP dengan Framework Codeigniter dan aplikasi Android menggunakan Bahasa pemrograman Dart dengan Framework Flutter. Sedangkan dalam metode pengujian sistem menggunakan pengujian blackbox testing.Kata kunci: Perpustakaan, Aplikasi e-Library, Android, RAD
ANALISIS DATA FLIGHT OPERATION QUALITY ASSURANCE (FOQA) GARUDA INDONESIA BERBASIS WEB DI PT. GMF AEROASIA TBK
Authors: Taufiq Rohmat , Pradipta Angga , Septarini Ri Sabti , Priadi Andhika Aratida
Published: July 2021

Sistem pengolahan data pelaporan download Flight Operation Quality Assurance (FOQA) pada unit Flight Data System (FDS) yaitu dengan cara mengisi mengisi form online yang masih dalam bentuk google form, pelaporan ini dilakukan oleh petugas downloader. Pelaporan ini dilakukan dengan 3 tahap, yang pertama menulis dikertas download form, kemudian mengisi form online. Kemudian data yang diupload akan di analisa oleh engineer dan di check oleh manager. Oleh sebab itu harus di cari alternatif dalam penanganan data tersebut.Berdasarkan latar belakang tersebut, masalah yang di analisa adalah manager harus melihat tiga kali laporan petugas downloader, sehingga solusi terbaik adalah bagaimana cara membuat sebuah aplikasi web untuk mengolah data pelaporan download, supaya kinerja di unit Flight Data System (FDS) lebih efektif. Metode yang di lakukan dalam penulisan laporan ini adalah metode waterfall. Sehingga pelaporan kepada atasan lebih efektif terperinci, mudah cepat dan akurat.
Relação entre diabetes e sintomas depressivos
Authors: Jorgetto Giovanna Vallim , Marcolan João Fernando , Jorgetto Juliana Vallim
Published: July 2021

Objetivo: Relacionar prevalência de depressão associada ao quadro de Diabetes Mellitus tipo 2, de população adulta de cidade do sul de Minas Gerais. Método: Estudo de análise documental, descritivo, retrospectivo de campo, em prontuários físicos/ eletrônicos do e-sus de indivíduos com Diabetes Mellitus tipo 2. Utilizado instrumento com informações sociodemográficas e clínicas relativas ao diabetes e sintomas depressivos. Análise de dados por média, desvio padrão, teste qui-quadrado (p<0,05) e correlação de Pearson (r>0,5). Resultados: Levantados 317 prontuários de indivíduos com diabetes tipo 2 (10,40% da população) e destes, analisados 226 prontuários (30,08%) que apresentaram sintomatologia depressiva correlacionada. Média de idade 63 anos (dp= 5,44), maioria sexo feminino (64,66%), faixa etária 50/70 anos. Sintomas depressivos foram mais prevalentes nas mulheres (31,7%), com renda mensal até dois salários mínimos, 42,08% eram aposentados e 71,68% apresentaram tempo de doença entre 5 a mais de 20 anos. Conclusão: Prevalência de diabetes tipo 2 acima da média nacional em população geral, com elevada prevalência de co-morbidade como o quadro depressivo. Deve-se realizar planejamento e intervenções específicas para a problemática por parte dos gestores municipais. Estudo contribui para revelar situação de prejuízo à saúde que não tinha sido detectado.
Risco elevado do desenvolvimento das doenças crônicas não transmissíveis em cuidadores de pessoas idosas
Authors: Oliveira Filho Vilmar da Conceição , Sá Selma Petra Chaves , De Souza Rocha Gabrielle , Domingos Ana Maria , Soares Rafael da Silva , Barroso Taianah Almeida
Published: July 2021

Introdução: A baixa qualidade de vida associada ao sobrepeso e a circunferência abdominal elevada em cuidadores, demonstra ser um fator de risco para o desenvolvimento de doenças crônicas não transmissíveis. Objetivo: Relacionar características sociodemográficas, antropométricas com a qualidade de vida de cuidadores. Método: Estudo transversal, com 31 cuidadores, atendidas no Centro de Atenção à Saúde do Idoso e seus Cuidadores. Responderam um questionário sociodemográfico e realizaram antropometria com as seguintes variáveis: peso, estatura, circunferência abdominal (CAb) e cálculo do índice de massa corporal (IMC), a CAb e o IMC foram classificados segundo a Organização Mundial da Saúde, 2000. A qualidade de vida foi mensurada pela escala SF-36. No tratamento de dados foram realizados os testes de Shapiro Wilk e Mann-Whitney no software SPSS (22.0).  Resultados: 45,16% eram formais, 61,3% possuíam o ensino médio completo e 38,8% ganhavam 2 salários mínimo ou menos. A obesidade foi de 35,5% e de CAb maior que 88 cm foi 71,1%. Observou-se que cuidadores, no geral, apresentavam pior qualidade de vida nos domínios dor e estado geral. Conclusão: Os cuidadores apresentaram baixa renda, nível de escolaridade variado, predomínio significativo do sobrepeso e circunferência abdominal elevada. A qualidade de vida apresentou associação com o estado nutricional.
Percepção e práticas da população atendida nos serviços primários de saúde sobre a Raiva
Authors: Lovadini Vinicius de Lima , Lorena Laura Luisa Gonçalves , Lacerda Jaqueline da Silva , Marinho Márcia
Published: July 2021

A raiva é uma encefalite viral aguda, transmitida por mamíferos com letalidade próxima de 100%, acarretando graves problemas econômicos e na saúde pública, principalmente em países em desenvolvimento e subdesenvolvidos. Enfermidade causada por vírus do gênero Lyssavirus, pertencente à família Rhabdoviridae, que se espalha pelo sistema nervoso central e encontra-se em sobressalentes concentrações nas glândulas salivares de seu reservatório. O objetivo do trabalho foi avaliar o conhecimento da população usuária das Unidades Básicas de Saúde em relação à Raiva no município de Birigui, estado de São Paulo. Para tanto utilizou-se um questionário com questões fechadas a fim de identificar e categorizar o conhecimento e atitudes da população frente à Raiva. Foram entrevistados 400 pacientes de ambos os sexos, escolhidos de forma randômica. Nossos resultados revelaram que 74,25% (297/400) dos entrevistados eram do sexo feminino, sendo 44% (176/400) alocados na faixa-etária entre 31 a 50 anos, 45,25% (181/400) possuíam o ensino médio completo, 97,25% (389/400) já tinham, ouvido falar sobre a Raiva, 67% (268/400) sabiam quais eram os transmissores da enfermidade e 85,05% (256/400) adotavam esquema imunoprofilático contra a Raiva em seus animais. Pelo exposto concluímos que a população demonstrou conhecimento elevado sobre a Raiva, visto que em sua maior parte os entrevistados souberam quais eram os fatores causadores da doença como a transmissão, letalidade, terapêutica e medidas de prevenção, além de já terem ouvido falar sobre a zoonose em sua maior parte por meios digitais ou trocas de informações entre os indivíduos.
Retraction: Ghali MGZ, et al. Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons. Journal of Integrative Neuroscience. 2020; 19: 521–560
Authors: Ghali Michael G. Z. , Ghali George Zaki , Lima Adriana , McDermott Michael , Glover Emma , Voglis Stefanos , Humphrey Jennifer , König Marton Skog Steinberger , Brem Henry , Uhlén Per , Spetzler Robert F. , Yasargil M. Gazi , Office Journal of Integrative Neuroscience Editorial
Published: July 2021

The above-mentioned article [1], published online on 30 September 2020, has been withdrawn. The retraction has been issued following additional information based on an issue raised by the KAROLINSKA INSTITUTET, Sweden, in regards to a disputed domain name. This was received by IMR Press and reviewed by the Chief Editor.
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease
Authors: Xing Feng , Meng Tao , Therriault Joseph , Luo Jing , Zhang Hua , Initiative Alzheimer’s Disease Neuroimaging
Published: July 2021

Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial. The research checks the hypothesis that the relationships between apolipoprotein E alleles and cerebrospinal fluid tau and cognition differ in persons with and without significant amyloid-β deposition. We divided 1119 subjects into cognitively normal (n = 275), mild cognitive impairment (n = 629), and Alzheimer’s disease (n = 215), and these subjects were from the Alzheimer’s Disease Neuroimaging Initiative database. Linear regression models were used to compare the relationships of apolipoprotein E alleles with cerebrospinal fluid tau and cognition in persons with significant amyloid-β deposition relative to individuals without significant amyloid-β deposition. The associations of apolipoprotein E ε4 and ε3 with total tau (T-tau), phosphorylated tau (P-tau), and Alzheimer’s disease assessment scale was significantly substantial among participants with significant amyloid-β deposition. Stratified analyses showed that apolipoprotein E ε4 related to increased concentrations of T-tau, P-tau, and Alzheimer’s disease assessment scale and apolipoprotein E ε3 associated with decreased concentrations of T-tau, P-tau, and Alzheimer’s disease assessment scale in mild cognitive impairment participants with significant amyloid-β deposition, but not in Alzheimer’s disease. Our study shows that the presence of apolipoprotein E ε4 and ε3 alleles is related to tau pathology and cognitive impairment in the presence of amyloid-β in mild cognitive impairment, but not in Alzheimer’s disease. This work indirectly provides additional evidence that apolipoprotein E and amyloid-β may not have a role in modulating clinical Alzheimer’s disease, and apolipoprotein E ε3 may be supposed to be protective to mild cognitive impairment.
Abnormal magnetic resonance imaging of the sellar region and its surroundings in patients with pituitary abscess
Authors: Wu Zhifeng , Qiu Yanwu , Lin Haiqing , Wang Shousen
Published: July 2021

Pituitary abscess is a rare disease with a high preoperative misdiagnosis rate. Magnetic resonance imaging is the primary method for confirming pituitary abscesses before surgery. We reported magnetic resonance imaging findings of four cases of pituitary abscess (three males and one female) aged from 33 to 72 years old. All four cases underwent transnasal sphenoid surgery and had a good prognosis. The findings on magnetic resonance imaging were analyzed. Three cases showed ring enhancement of the capsule wall. Four cases showed thickened pituitary stalk, with the diameter of the lower end larger than that of the upper end. The position of the pituitary stalk where it was inserted into the upper edge of the pituitary was located at the middle and posterior 1/3 junction of the upper edge of the pituitary two cases were with the enhancement of the dura mater at the bottom of the temporal lobe. Two cases were with the enhancement of the dura mater of the petroclival region, and one case was with the enhancement of the cavernous sinus. There are few articles concerning abnormal magnetic resonance imaging around the sellar region of pituitary abscess. The findings of the four cases in this article suggest that the pituitary abscess has characteristic abnormal magnetic resonance imaging of the sellar region and its surroundings.
Long-term results of endovascular intervention with unibody bifurcation endograft for elective abdominal aortic aneurysm management
Authors: İşcan Hakkı Zafer , Karahan Mehmet , Akkaya Bekir Boğaçhan , Başar Veysel , Aşkın Göktan , Kubat Emre , Aytekin Bahadır , Ünal Ertekin Utku
Published: July 2021

Unibody bifurcated endografts have the advantage of reducing the operative time, avoiding migration and iliac limb dislocation in patient with abdominal aortic aneurysm (AAA). We report our long-term experience in patients who underwent endovascular aortic repair (EVAR) due to infrarenal AAA with Endologix AFX® endograft system. Between January 2013–December 2018, 68 patients with infrarenal AAA had EVAR procedure with Endologix AFX® endograft system. Mean follow-up was 40.4 ± 19.5 months, and all patients had computed tomography periodically, with colored Doppler ultrasonography (CDUS) every six months. Mean age was 68.5 ± 7.1 years and, 63 (92.6%) patients were male. Early mortality, renal complications, stent-graft migration and cardiac complications were not seen in early post-operative period. There was no early mortality in the group and no conversion to open repair. In long-term follow-up 12 patients (17.6%) had endoleak (5 with type II, 7 with type III). Overall survival estimated by Kaplan-Meier analysis was 94.1% at 1 year, 85.2% at 2 years, 74.1% at 3 years and 54.0% at 5 years. Freedom from second intervention and conversion was 98.4% at 1 year, 95.3% at 2 years, 93.3% at 3 years and 87.4% at 5 years. Endologix AFX® endograft provides a fast, safe and effective endograft for the early period, therefore it seems more suitable for elderly and comorbid patients. This endograft has low reintervention rates however according to our results, aneurysms larger than 6 cm may have more sideway displacement possibility and by this way type III endoleak. Proper patient selection and sufficient overlap are the key issues. Close monitoring is mandatory at the follow-up period.
The pathomechanism of human myxomatous valvular degeneration at the mechanical and cellular level
Authors: Hu Chang , Wang Qian , Xue Hui , Hong Hao , Shi Jiawei , Dong Nianguo , Zhang Mingkui
Published: July 2021

The purpose of this study was to explore the pathomechanism of human myxomatous valve degeneration by investigating changes in the phenotype of valvular cells, the metabolism of the extracellular matrix and their mechanical properties. Mitral valve specimens were harvested from patients who had undergone valve replacement, and divided into two groups: patients with a myxomatous mitral valve and a control group. Histological investigation showed that the morphology of the extracellular matrix was looser and less coordinated in myxomatous valves than in controls. α-SMA (α-smooth muscle actin) and Vimentin were positive and DNA (deoxyribonucleic acid) assay of leaflets and expression of SMemb (embryonic smooth muscle myosin heavy chain), MMP-13 (matrix Metalloproteinases-13), MMP-1 mRNA (messenger Ribonucleic Acid) of the myxomatous valves were increased while the hydroxyproline content, expression of TIMP-1 (tissue inhibitor of metalloproteinase-1) mRNA and mechanical properties were decreased compared with controls. Compared to the quiescent interstitial cells in non-myxomatous valves, interstitial cells in myxomatous valves exhibit myofibroblast activation and express excessive levels of matrix metalloproteinases. The balance between MMP/TIMP was disrupted. We conclude that overactivation of VICs (Valvular interstitial cells) and the imbalance of MMP/TIMP could be important features of the pathomechanism of myxomatous mitral valve degeneration.