bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisa keseimbangan Lintasan dengan Metode Killbridge Wester dan Helgeson Birnie (Studi Kasus : Line Welding PT. Suzuki Indomobil Motor Plant Tambun II)
Authors: Krisnawati Maria , Pertiwi Nita , Suparjiyanto Suparjiyanto
Published: July 2022

Penelitian ini merupakan studi kasus yang dilakukan pada Line Welding PT. Suzuki Indomobil Motor Plant Tambun II. Hasil dari analisis efisiensi lini menunjukkan bahwa lini rear floor YR9 memiliki efisiensi paling rendah yaitu 75,16 %. Oleh karena itu, peneliti melakukan analisa pada lini rear floor YR9 dengan metode Line Balancing. Peneliti melakukan Analisa perbaikan lini dengan dua metode yaitu Killbridge Wester dan Hegelson Birnie dengan menggunakan Cycle Time (CT) = 20,09 menit dan CT=19 menit untuk line efficiency, balance delay, dan smoothness index. Berdasarkan analisis, metode Hegelson Birnie dengan CT= 19 menit menghasilkan nilai line efficiency yang terbaik yaitu sebesar 94,22%, nilai balance delay sebesar 5,70%, dan nilai smoothness index sebesar 1,32.
NGO-Corporate Partnerships: Sustainable Development Impact for Indian Children
Authors: Hapsari Karina Erdian
Published: July 2022

This paper reviews the importance of NGO-corporate partnerships towards sustainable development for Indian children. Specifically, this paper analyzes CRY India and the three big corporations – Marks & Spencer, Microsoft, Bajaj Finserv – as the research subject. The NGO-corporate partnerships are crucial in the sustainable development process. Moreover, in India, the number of child labor is increasing.  Thus, in order to achieve sustainable development, the child labor issue must be tackled in the right ways as children are the basis for all dimensions of sustainable development. For analysis, this paper uses an explanative approach, with secondary data. The analysis found that there are two reasons to explain their significant partnerships, as a ‘bridge’ between the actors and long-term potential value. A bridge between the actors in this paper refers to CRY India-three big corporations (Marks & Spencer, Microsoft, Bajaj Finserv) interrelations. These interrelations illustrate the needs of NGOs in funding and on the other hand, NGOs provide ‘space’ for corporate social responsibility through their programs. A ‘space’ in this paper refers to the access given by CRY India for corporates to do their CSR through CRY India’s projects as an altruistic action for both CRY and corporates. Meanwhile, the potential value leads to the benefit and impact that goes beyond partnerships, which is a better sustainable development for Indian children. In conclusion, the NGO-corporate partnerships are still needed to tackle today’s problem, and it might give an incredible impact. Though, there are some debates about their relations.
The Repetition Drill in Teaching Simple Present Tense
Authors: Kumayas Tirza
Published: July 2022

This research was the description of an attempt to find out the effective technique to overcome the students' problem in using verbs which deal with the third person singular in the simple present tense correctly. To solve the problem above, he used repetition drill as a technique. The method of this research is pre-experimental descriptive method with one pre-test and post-test. The population was the students in second year at English Education Department and the sample consisted of 34 students. According to the result of this research the writer used the statistic instrument in analyzing the obtained data. And the finding shows that the result of the mean score of pre-test is 4.06 and the mean score of post-test is 7.05; this means that the result of post-test is much better than the pre-test. It can be concluded that the use of Repetition drill technique was effectively to solve the students' problem. The writer suggested that English teachers use repetition drill in teaching to increase the students' mastery in using verbs which deal with the third person singular in simple present tense.

Keywords: Repetition Drill, Teaching, Simple Present Tense
Developing Students’ Skill in Writing Procedure Text Using YouTube Videos
Authors: Meiristiani Noeris , Agistina Nastasia
Published: July 2022

The purpose of this study is to determine whether YouTube videos are effective to use in teaching writing procedure text during the online learning process. It is experimental research with the population of all students of Class XI TMI in the first semester of SMK YPT Tegal in the academic year 2020/2021 with a total of 327 students. The sample was 40 students taken by using the cluster random sampling technique. The samples were grouped into two; (1) control group consisting of 20 students who were not taught using YouTube videos, and (2) experimental group consisting of 20 students who were taught using YouTube videos. The data analyzed using SPSS version 22 obtained the average post-test results of the two groups 78.50> 64.50. Based on the results of hypothesis testing using an independent sample t-test, a significance value of 0.000 was obtained, which was smaller than the significant value of a, which was 0.05, meaning that Ha was accepted. This means that there is a significant difference between the experimental group and the control group. In conclusion, the use of YouTube videos in teaching writing has a positive effect on the students’ writing skill.
Conducting Matrices of the Poly(-O-Toluidine, PTOL) Film for Immobilizing Uricase
Authors: Hermanto Dhony , Ismillayli Nurul , Zuryati Ulul Khairi , Kamali Siti Raudhatul
Published: July 2022

Polyaniline, PANI as conducting polymer has been used as enzyme immobilization matrix in biosensors due to its excellent stability and electrochromic effects, conductivity, and redox reversibility. However, at pH above 4, the electron transfer ability and redox activity decrease, henceit is necessary to modify the PANI structure to increase the PANI pH range. In this study, the PANI derivative, the poly(-o-toluidine, PTOL) film was produced for the uricase immobilization matrix. This study aimed to develop a supporting material that maintains catalytic activity uricase with a facile and inexpensive procedure. The PTOL was prepared by using the chemical oxidative polymerization technique with ammonium persulfate (dissolved in 1.0 M HCl) as an oxidizing agent. The FTIR spectra confirmed the success of PTOL formation by the appearance of its characteristic peaks. The UV-Vis spectra indicated that PTOL was in an emeraldine state with a semi-crystalline structure that was shown by its XRD pattern. While, SEM analysis described that the PTOL film was uniform with some granular aggregation in its surface morphology, but there is no holes or porosity were found. The use of PTOL film as a uricase matrix could maintain the uricase activity against the substrate (uric acid, UA) with excellent analytical characteristics. Therefore, PTOL film could be used as conducting matrices for immobilizing enzymes (e.g. biosensors).
ANALISIS KEMAMPUAN BERPIKIR KRITIS DAN KOMUNIKASI MATEMATIS SISWA DALAM PEMECAHAN MASALAH MATEMATIKA BERTIPE SOAL TIMSS
Authors: Febriyanti Sukma Dwi , Indiati Intan , Setyawati Rina Dwi
Published: July 2022

This study aims to describe students' critical thinking and mathematical communication skills Algebra material TIMSS type of question. This type of research is descriptive qualitative. The subjects were taken by 3 students each with high, medium and low math abilities in class VIII of SMPN 1 Jepara 2021/2022. Data was collected by means of critical thinking tests, mathematical communication, interviews and documentation. The data analysis technique was carried out in 3 stages, namely data reduction, data presentation and conclusion drawing. The technique of checking the validity of the data is using the triangulation method. Critical thinking analysis, 1 student with high mathematical ability who fulfills all indicators while the other 2 students only meet 2 critical thinking indicators. Students with moderate mathematical ability 3 students who are only able to fulfill 1 indicator of critical thinking. Students with low mathematical abilities, 1 student who is only able to fulfill 1 indicator while the other 2 students are not able to fulfill all critical thinking indicators. For mathematical communication, students with high mathematical ability met 5 indicators of mathematical communication, 2 students with moderate mathematical ability met 3 indicators but the indicators achieved were different while 1 other student met 4 indicators of mathematical communication. 2 students with low mathematical ability met 1 indicator and 1 other student was not able to fulfill all mathematical communication indicators.
Studi relokasi gempamikro menggunakan teknik double-difference
Authors: Hidayat Wahyu
Published: July 2022

Penentuan lokasi merupakan kegiatan pertama dan utama dalam bidang seismologi. Penentuan lokasi hiposenter yang akurat dan presissi dibutuhkan untuk meminimalisi potensi seismic hazard. Pada tambang bawah tanah event – event gempa umumnya  terjadi di bukaan tambang, hal ini diakibatkan oleh kompensasi massa yang diambil yang mengakibatkan munculnya stress. Akumulasi stress yang tinggi mengakibatkan terjadinya event gempa mikro. Penelitian ini bertujuan untuk mendapatkan relokasi hiposenter yang akurat pada tambang bawah tanah. Data yang digunakan adalah katalog gempa selama 2 bulan dari area tambang bawah tanah di daerah Jawa Timur. Jumlah event gempa sebanyak 1783 dengan magnitude gempamikro dari -1.3 sampai dengan 1.5 Mw. Untuk mendapatkan tingkat akurasi dan presisi yang tinggi terutama dalam penentuan lokasi serta kedalaman dalam penentuan hiposenter digunakan teknik Double - Difference (DD). Hasil relokasi gempamikro  menunjukan dari 1783 event terelokasi 1765 dengan total phase mencapai 2994. Fase gelombang P terseleksi pasangan sebanyak 49910 dari 57991 (86%), sedangkan untuk fase gelombang S terseleksi pasangan sebanyak 24943 dari 28752 (86%). Pergeseran gempamikro sebelum dan  setelah direlokasi menyebar ke segala arah dengan arah dominan berarah NE – SW. Nilai pergeseran gempamikro sebelum dan setelah direlokasi berkisar dari 0.01meter sampai dengan 13 meter
Pengaruh ketebalan lapisan polistiren terhadap kestabilan sensor QCM sebagai bioimunosensor
Authors: Rahmawati Eka , Masruroh Masruroh
Published: July 2022

QCM telah banyak digunakan sebagai biosensor dan sensor kimia. Tingkat sensitifitas yang dimilikinya terhadap perubahan massa pada permukaannya . Terdapat banyak aspek yang dapat mempengaruhi kerja QCM ketika memiliki kontak dengan larutan. Salah satunya adalah ketebalan lapisan matriks yang menjadi lapisan biologi yang akan diimobilisasikan di atasnya. Salah satu matriks biologi yang menjadi lapisan adalah polistiren. Metode pelapisan polistiren di atas QCM sensor yakni dengan menggunakan metode spin coating. Sebelumnya polistiren dilarutkan dengan pelarut non polar: xilen dan Tetrahidrofuran (THF) yang memiliki properti kimia dan fisika yang berbeda yang berpengaruh pada proses pembentukan lapisan dari polimer terlarut menjadi lapisan polimer yang kaku. Penggunaan pelarut dan konsentrasi polistiren berbeda menghasilkan ketebalan lapisan yang beragam. Selain itu ditemukan pula, terdapat perbedaan tingkat kestabilan QCM ketika terjadi kontak dengan udara dan larutan PBS pada masing-masing variasi konsentrasi polistiren yang digunakan. Sensor QCM memiliki kestabilan yang baik pada lapisan polistiren ≤ 5% untuk pelarut xilen dan ≤ 3%  untuk pelarut THF dengan nilai tegangan peak to peak ≥ 1 V. QCM-polistiren yang stabil dapat digunakan untuk melakukan immobilisasi sebagai biosensor.
Identifikasi frekuensi bunyi gambang laras slendro gamelan Jawa menggunakan jaringan syaraf tiruan pada Matlab
Authors: Aisah Salma Sukmawati Nur , Abdullatif Farzand , Hartono Hartono
Published: July 2022

Penalaan gambang laras slendro selama ini dilakukan dengan mempertimbangkan perasaan yaitu perasaan enak atau tidak enak bunyi didengar. Dengan cara ini keselarasan dapat berubah seiring dengan perasaan pengrajin, selain itu akan berbeda pula antara pengrajin satu dengan pengrajin lainnya. Penelitian bertujuan untuk membuat sistem yang mampu menggantikan orang dalam penalaan nada berdasarkan Artificial Intelligence. Sistem menganalisis karakteristik tiap nada bilah dengan meninjau frekuensi fundamental mengunakan algoritma Fast Fourier Transform (FFT) yang dimiliki oleh program Matlab, dan meninjau hubungan antara ukuran bilah dan frekuensi yang dihasilkan. Sebuah program Jaringan Syaraf Tiruan (JST) dibuat untuk membantu dalam identifikasi dan untuk mempermudah menjalankan program dibuat tampilan sederhana menggunakan GUI (Graphical User Interface). Hasil penelitian menunjukkan bahwa frekuensi fundamental dapat ditentukan dari puncak tertinggi dalam sebuah spektrum frekuensi dan ukuran bilah berpengaruh terhadap pembuatan nada. Sistem penala gambang slendro menggunakan JST dapat mendeteksi secara benar 47,5% sampel dalam pengujian
Statistical Quality Control of Ultra High Temperature (UHT) Milk in PT XYZ
Authors: Sitorus Ester Mastiur , Mela Ervina
Published: July 2022

Ultra high temperature (UHT) milk is a product that is widely consumed because of its practicality and hygiene. PT XYZ is one of the industries that produces UHT milk with chocolate and strawberry flavors. Based on company records, there are variations in the protein content of the two products. The purpose of this study was to determine the average protein content of chocolate and strawberry milk on the control chart and to develop a cause-and-effect diagram to determine the factors that triggered variation in protein levels in PT XYZ's chocolate milk and strawberry milk. The research data was obtained from company records, which were then analyzed using MR control charts and fishbone diagrams. The results showed that there were values that were outside the control limits, both in the chocolate and strawberry flavor variants. The cause of the variability in the value of protein content in UHT milk in both chocolate and strawberry flavors comes from 4 factors. The machine factor is in the form of machine checking, which is still curative. The human factor is a lack of human resources and the absence of regular employee training. The factor of the method of using materials that are still manual Material factors are in the form of non-uniformity of sources and quality of raw materials for fresh milk from suppliers, and differences in quality and type of raw materials (between fresh milk and recombined milk).
The Influence of The Addition of Potato (Solanum Tuberosum) And Extract of The Skin of The Dragon Fruit on The Level of Flow and Organoleptic Ice Cream
Authors: Meilani Delia , Purwanti Yunika , Fera Melly , Daryono Daryono
Published: July 2022

Potato is one of the tubers that can be used as an alternative source of non-fat solids in the manufacture of ice cream, which can act as an emulsifier that functions to slow down the melting power of ice cream. As for the coloring material, dragon fruit peel extract is used because it has a purplish red pigment and is rich in anthocyanin content as a natural dye. This study aims to determine the level of melting of potato ice cream and the organoleptic properties of ice cream with the addition of potatoes and dragon fruit peel extract as natural dyes. The method used in this study was a completely randomized design (CRD) with two factors, namely factor 1 combination of full cream milk: potato (25:75; 50:50; 75:25) and factor 2 the addition of dragon fruit peel extract (10 ml, 20 ml). ml, 30 ml) with 3 replications. The best treatment results were K₃E₃, namely the composition of 75gr full cream milk and 25 gr potatoes, 30 ml dragon fruit peel extract, which resulted in the highest score on aroma (3.84), color (3.86), texture (4.30), and liking (3.96).
Utilization of Nanocellulose Fiber from Tapioca Industrial Solid Waste as a Bioplastic Filling Material
Authors: Wicaksono Rumpoko , Wijayanti Nur
Published: July 2022

This study aims to examine the properties of nanocellulose fibers produced from cassava through the acid hydrolysis process, as well as their potential use as a filler for bioplastics based on cassava starch (tapioca). The treatment of this research was acid hydrolysis process time consisting of 15 and 30 minutes and the use of nanocellulose fiber as a filler for bioplastics as much as 0%, 1%, 2%, and 3% w/w starch. The results of this study indicate that the diameter of the nanocellulose fibers produced is about 18-40 nm, good dispersion stability, the crystallinity index of the nanocellulose fibers produced by acid hydrolysis for 15 and 30 minutes are 39.7% and 31.2%, respectively. The addition of nanocellulose fibers can increase the tensile strength, but decrease its elongation ability.
Internet-based physical activity promotion in the post pandemic era
Authors: Zein Muhammad Ikhwan
Published: July 2022

No abstract
Protective effect of ethanolic extract of white oyster mushroom on morphological rat sperm damage due to cigarette smoke exposure
Authors: Rahimah Santun Bhekti , Dananjaya Rio , Dananjaya Rio , Widyastuti Ermina , Widyastuti Ermina , Feriandi Yudi
Published: July 2022

Background: Cigarettes smokes are a great external source of free radicals. The negative effects of cigarette smoke exposure can be systemic and affect all body systems, including the reproductive. Male rats exposed to cigarette smoke have a risk of oxidative stress and sperm damage. This can be overcome with herbal antioxidants such as white oyster mushrooms (Pleurotus ostreatus).Objective: This study aimed to examine the protective effect of ethanolic extract of white oyster mushroom against damage to sperm morphology of rats exposed to cigarette smoke.Methods: This study is an experimental study using 40 rats which were divided into 5 groups. Group I (normal control), group II (negative control) were only given exposure of cigarette smoke, Grups III, IV and V (treatments groups 1, 2, and 3) were given exposure of cigarette smoke and ethanolic extract a dose of 125, 250, and 500 mg/Kg BW/day for 14 days. On the 15th day, the percentage normal rat sperm were calculated under a 400x magnification microscope.Results: Normal sperm count in group I was 79% ± 0.79, group II was 39% ± 0.55, Grup III, IV and V were 56% ± 0.15, 65% ± 0.54 and 66% ± 0.21.
The potency of red onion skin flavonoids in acetaminophen-induced liver injury management: A biomolecular review
Authors: Ardianto Radya Kusuma , Abimanyu Lucky Dimas , Waliyuddin Afif Wafiq , Noerwahjono Abi , Lestari Dian Yuliartha , Safithri Fathiyah
Published: July 2022

Acetaminophen is widely used as a fever and pain reliever drug. However, acetaminophen intoxication was common and responsible for thousands of acetaminophen-induced liver injury (AILI) cases worldwide. It was understood that glutathione (GSH) depletion causes a deposit of acetaminophen metabolites which are toxic to liver cells. N-acetylcysteine (NAC), used as acetaminophen intoxication therapy, has been reported to cause side effects such as nausea, vomiting, and anaphylactic reaction. This narrative review aimed to discuss other potential candidates in AILI management. The biomolecular approach was used to investigate onion skin in-depth and holistic discussion. According to the results, onion peel extract is rich in flavonoids (quercetin and kaempferol) and potentially be a candidate in the management of AILI through proposed mechanisms such as restoration of reduced glutathione (GSH), inhibition of cytochrome P450 (CYP) enzymes, upregulation of uridine 5'-diphospho-glucuronosyltransferase (UGT) enzyme, and inhibition of TLR4 activity.
The time administration and cost burden of intravenous immunoglobulin (IVIG) therapy in a 4-year-old girl with Kawasaki disease: A case report
Authors: Agustina Nenden Nursyamsi , Arjadi Fitranto
Published: July 2022

Kawasaki disease (KD) is an acute systemic vasculitis frequently affecting children under five years old. KD can cause severe complications. It can lead to coronary aneurysms in 15-25% of untreated cases. Intravenous immunoglobulin (IVIG) treatment within ten days of initial onset can reduce the rate of coronary artery aneurysms. However, IVIG administration in Indonesia is currently limited due to its high cost. The case reported a 4-year-old girl with a chief complaint of fever. She complained about a high fever seven days before hospitalization. She also complained about vomiting, cough, joint pain, diarrhea, skin peeling, and rash on her body, palms, and soles. On examination, she looked irritable and sluggish. The temperature was 39.9o C. There were red eyes without discharge, strawberry tongue, oral thrush, and red, dry, cracked lips, swollen neck lymph nodes, and skin rash on her body, palms, and soles. Laboratory testing showed microcytic hypochromic anemia with Hb 7.9 g/dL and leukocytosis 24.230/mm3. Chest X-ray showed perihilar and paracardial infiltrates. Electrocardiogram revealed sinus tachycardia. An echocardiogram showed left ventricle dilatation with trivial mitral regurgitation and no coronary abnormalities were found. She was diagnosed with Kawasaki Disease. She was treated by IVIG 30 gr single dose during 12 hours on day 7 of initial onset, methylprednisolone injection 10 mg/8 hours, paracetamol 150 mg/8 hours, and aspirin 400 mg/8 hours orally and discharged from the hospital with improvement. There weren’t any coronary artery abnormalities found. IVIG administration within ten days of initial onset in KD patients can reduce the risk of coronary artery complications. IVIG administration after day 10 of initial onset can achieve resolution of inflammation but can be insufficient for preventing coronary artery lesions (CALs).
Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets
Authors: Zhao Huanyu , Dang Ruoyu , Zhu Yipan , Qu Baijian , Sayyed Yasra , Wen Ying , Liu Xicheng , Lin Jianping , Li Luyuan
Published: July 2022

Objective: The aim of this study was to identify hub genes associated with immune cell infiltration in breast cancer through bioinformatic analyses of multiple datasets. Methods: Nonparametric (NOISeq) and robust rank aggregation-ranked parametric (EdgeR) methods were used to assess robust differentially expressed genes across multiple datasets. Protein-protein interaction network, GO, KEGG enrichment, and sub-network analyses were performed to identify immune-associated hub genes in breast cancer. Immune cell infiltration was evaluated with the CIBERSORT, XCELL, and TIMER methods. The association between the hub gene-based risk signature and survival was determined through Kaplan–Meier survival analysis, multivariate Cox analysis, and a nomogram with external verification. Results: We identified 163 robust differentially expressed genes in breast cancer through applying both nonparametric and parametric methods to multiple GEO (n = 2,212) and TCGA (n = 1,045) datasets. Integrated bioinformatic analyses further identified 10 hub genes: CXCL10, CXCL9, CXCL11, SPP1, POSTN, MMP9, DPT, COL1A1, ADAMDEC1, and RGS1. The 10 hub-gene-based risk signature significantly correlated with the prognosis of patients with breast cancer. Moreover, these hub genes were strongly associated with the extent of infiltration of CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and myeloid dendritic cells into breast tumors. Conclusions: Integrated analyses of multiple databases led to the discovery of 10 robust hub genes that together may serve as a risk factor characteristic of the immune microenvironment in breast cancer.
Anti-tumor pharmacology of natural products targeting mitosis
Authors:   Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, Huang Manru ,   State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, Liu Caiyan ,   Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, Shao Yingying ,   Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, Zhou Shiyue ,   Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, Hu Gaoyong , Yin Shuangshuang ,   Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, Pu Weiling ,   Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China, Yu Haiyang ,   Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Published: July 2022

Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer’s main characteristics, which is closely associated with abnormal mitosis. Targeting mitosis is an effective method for cancer treatment. This review summarizes several natural products with anti-tumor effects related to mitosis, focusing on targeting microtubulin, inducing DNA damage, and modulating mitosis-associated kinases. Furthermore, the main disadvantages of several typical compounds, including drug resistance, toxicity to non-tumor tissues, and poor aqueous solubility and pharmacokinetic properties, are also discussed, together with strategies to address them. Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.
Analisis Tingkat Pengetahuan dan Sikap Apoteker terhadap Obat Generik di Wilayah Kabupaten Banyumas
Authors: Selifani Nur Fauzi , Pratiwi Hening , Mustikaningtias Ika
Published: July 2022

Obat generik telah digunakan di beberapa wilayah di Indonesia namun masih relatif rendah. Pengetahuan dan sikap apoteker di apotek terhadap obat generik berperan penting dalam menentukan peningkatan persentase penggunaan obat generik. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan dan sikap apoteker di apotek Kabupaten Banyumas terhadap obat generik serta hubungannya dengan karakteristik responden. Penelitian ini merupakan penelitian non-experimental dengan metode cross-sectional. Metode pengambilan sampel yaitu accidental sampling. Pengambilan data menggunakan kuesioner dilakukan secara daring kepada apoteker di apotek Kabupaten Banyumas melalui google form. Kuesioner diadaptasi dan dimodifikasi dari penelitian terdahulu. Analisis deskriptif dilakukan untuk data karakteristik, tingkat pengetahuan, dan sikap. Tingkat pengetahuan dikategorikan menjadi baik, cukup, dan kurang, sedangkan sikap menjadi positif dan negatif. Analisis korelatif dengan uji korelasi Spearman dilakukan untuk data hubungan karakteristik dengan tingkat pengetahuan dan dengan sikap. Penelitian melibatkan 67 apoteker sebagai responden. Apoteker memiliki pengetahuan baik terhadap obat generik (59,7%), sisanya cukup dan kurang. Apoteker memiliki sikap positif terhadap obat generik (98,5%), sisanya negatif. Tidak terdapat hubungan signifikan antara jenis kelamin (p=0,188), usia (p=0,536), lama pengalaman berpraktik (p=0,135), dan tingkat pendidikan (p=0,360) dengan tingkat pengetahuan apoteker. Terdapat hubungan signifikan antara tingkat pendidikan (p=0,004) dengan sikap terhadap obat generik, namun tidak terdapat hubungan signifikan antara jenis kelamin (p=0,080), usia (p=0,061), dan lama pengalaman berpraktik (p=0,744) dengan sikap. Tidak terdapat hubungan signifikan antara semua karakteristik dengan tingkat pengetahuan dan hanya tingkat pendidikan yang memiliki hubungan signifikan dengan sikap terhadap obat generik.
Pelatihan Pembuatan Minuman Serbuk Instan Kelakai dan Inovasi Marketing pada Mahasiswa
Authors: Suhartono Eko , Marisa Dona , Istiana Istiana , Hayatie Lisda
Published: July 2022

Pendahuluan: Mahasiswa yang memulai usaha atau membentuk usaha baru belum banyak. Hasil survey awal diketahui bahwa bahwa 11,6% mahasiswa berminat untuk wirausaha bidang makanan dan minuman kesehatan. Berkaitan dengan tersebut dilakukan pelatihan ini bertujuan untuk menghasilkan produk dan wirausaha minuman serbuk instan kelakai di kalangan mahasiswa.

Metode: Metode yang digunakan adalah induktif partisipatif secara kelompok dan individu, yang diikuti oleh 63 peserta (3 narasumber dan 60 mahasiswa). Pemberian  materi  melalui aplikasi Zoom Cloud Meeting. Materi yang diberikan mulai pemilihan bahan hingga cara pemasaran melalui media sosial.

Hasil dan Pembahasan: Kegiatan pelatihan pembuatan minuman serbuk instan kelakai dan inovasi marketing pada mahasiswa Fakultas Kedokteran Universitas Lambung Mangkurat berjalan dengan lancar. Para peserta antusias dalam mendengarkan pemaparan materi, dan aktif dalam tanya jawab seputar pembuatan konten-konten pemasaran di media social.

Kesimpulan: kegiatan ini adalah mahasiswa termotivasi untuk  membuat usaha baru terutama penggunaan aplikasi untuk marketing.
GAS-CONDENSATE FLUID PVT MODEL QUALITY CHECK BASED ON THE CONCEPT OF A SINGLE-CELL SIMULATION MODEL
Authors: Oleksandr Volodymyrovych Burachok  , Dmytro Volodymyrovych Pershyn  , Serhii Vasylovych Matkivskyi  , Yefim Semenovych Bikman  , Oleksandr Romanovych Kondrat  , Viacheslav Yuriiovych Filatov
Published: July 2022

The problems of gas-condensate PVT-models (Pressure Volume Temperature, PVT) creation under limited input information were analyzed. Traditional fluid phase behavior characterization approach relies on creation of the equation of state (EOS) based on initial composition of reservoir fluid and its future regression for critical parameters (pressure and temperature), binary interaction coefficients, acentric factors of residual “plus” fraction or pseudo-components. The adjustment is done until the moment when EOS is reproducing the results of laboratory experiments. Classic PVT experiments performed on gas-condensates and volatile oils are constant composition expansion (CCE), constant volume depletion (CVD) and separator tests. However, in the case of most Ukrainian fields, discovered and explored in the last century, not only the reliable detailed initial fluid composition is not available, but phase behavior was studied with non-equilibrium method of so-called differential condensation, that does not allow their direct application for PVT models creation. Previously, the authors [1, 2] presented an alternative method for fluid characterization based on the fractional distillation test. At the same time, due to significant uncertainty in input data, particularly a) condensate production allocation; b) commingled production from multiple reservoirs with different C5+ yield; c) non-recorded change of separator conditions that affects liquid extraction and its density; d) technological production losses, issues of reproducing the condensate production during history matching of several models of Dniper-Donetsk Basin were faced. There was proposed and explained in detail an example of single-cell reservoir simulation model application concept for quality check of created PVT model for one of the fields with potential yield of 86 g/m3. The idea of the concept is based on the reproduction of material balance of gas-condensate reservoir through one conditional well controlled on a primary (gas) phase, that allows quick identification of changes into calculated gas-condensate yield curve, necessary for matching of condensate production. Implementation of these changes allows quick and precise full-field model calibration.
INVESTIGATION OF CORROSIVE EFFECT ON METAL OF A BROAD FUEL FRACTION OBTAINED FROM SECONDARY POLYMER RAW MATERIAL
Authors: Andriy Borysovych Grigorov  , Kyryl Volodymyrovych Shevchenko  , Irina Valeriivna Sinkevich
Published: July 2022

A research of the corrosion effect on the metal (copper plate) of a broad fuel fraction (FPF) - a liquid product of thermal destruction of secondary raw materials made of low pressure polyethylene (LDPE) at temperatures up to 380 ° C and a pressure of 0,12-0,15 MPa. is conducted. Determination of the corrosion effect on the copper FFT plate was carried out in accordance with the standard ASTM D 130-10 at a temperature of 50 ° C for 120 minutes for both the dehydrated FFT sample and in the presence of 1% water. It was found that the copper plates, which were in the FFT and FFT + 1% water in the visual evaluation, had a light orange color, close to the color of the original plate. This, in turn, indicates that the investigated FFT samples have withstood the test, and the corrosive effect on the copper plate can be attributed to a slight fading, class 1.a. Also, together with the study under standard conditions, the corrosion effect on the copper plate of the products of combustion of FFT at different temperatures at which it was found that in the temperature range 180-230 ° C the surface of the copper plate becomes pale purple, and the corrosion effect on the copper plate can be attributed to moderate dimming, class 2.b; at temperatures of 230-290 ° the surface of the copper plate already has a silver color, and the corrosive effect on the copper plate corresponds to a moderate blackout, class 2.d. Therefore, when the combustion products of the FFT on the copper plate only oxygen corrosion occurs, which is due to the presence of oxygen in the area of the copper plate and the temperature of the combustion products. Thus, it was concluded that there is no corrosive elements in the FFT, which makes it suitable for use as a cheap component of motor, furnace and boiler fuels, improving their performance (e.g., reducing sulfur content).
STUDY OF MINING AND GEOLOGICAL FEATURES OF PROMISING CRUDE OIL-PRODUCING AREAS OF IRAQ
Authors: Ameer Mohammed Alajmeen Neamah  , Begench Halatovich Muhamedov  , Dmytro Fedorovich Donsky  , Sergii Viktorovich Nesterenko
Published: July 2022

Iraq is located on the northeastern parts of the Arabian Plate, which has been particularly exposed to tectonic movements in past geological periods, where there are several giant fields that contain most of the country’s oil reserves. The structural features of the oil fields of southern Iraq (Mishrif and Zubeir) form a number of factors that complicate the construction and operation of wells for oil production in the region.Possible negative consequences of the corrosion processes of oil and gas equipment and the prospective use of new technologies and materials were considered, taking into account the fact that waterflooding is currently the main technology in oil production in Iraq, which in these conditions requires a large amount of water and carries a number of negative factors that complicate operation of oil production equipment.These main factors are the content of acid gases (hydrogen sulfide and carbon dioxide), high mineralization of formation water, mainly due to the presence of chloride ions, elevated temperature, which is due to the depth of drilling and well operation. The negative consequences of corrosion of oil and gas equipment are given. The study was based on an integrated approach, which was carried out by analyzing data on the formation of geological conditions in southern Iraq (tectonics, stratigraphy, lithological-facial and hydrological analysis), generalization of world experience in oil production, use of oil and gas resources.
ALGORITHMIC PROVISION OF MONITORING OF IDENTITY OF CYLINDER POWERS OF POWER UNITS ON THE BASIS OF PROCESSING OF DIRECT INDIRECT DATA
Authors: Borysenko Anatoliy , Yenikieiev Oleksandr , Zakharenkov Dmitry , Zykov Ihor , Melnykov Oleksandr
Published: July 2022

A frequency-modulated instantaneous crankshaft speed signal is proposed as input information for monitoring the identity of the cylinder power of an internal combustion engine. Algorithmic software is based on solving a predefined system of linear algebraic equations with optimization of the solution based on the least-squares method. Frequency and time methods of signal measurement research are investigated. In the temporal representation, the system of algebraic equations is the balance between the values of the fluctuation signal of the first mass at specific points in time and the sum of the calculated contributions of the cylinders. The addition to the sum is determined by the product of the weights for the corresponding function of the contribution of the cylinder to the fluctuation signal. This function is calculated as the convolution interval between the torque of an individual cylinder and its transfer function. As a result of solving the system of equations, we obtain the weights of the cylinders, which are used to determine the distribution of cylinder power of the power unit. When comparing the methods, it was found that the time method of presentation provides better performance. A mathematical apparatus for estimating the maximum plausibility of the parameters of the determined components of the contributions of individual cylinders in the signal of fluctuations in the speed of rotation of the first mass of the crankshaft has been developed. An algorithm for estimating the weights of cylinders, which implements the correlation method of analysis, is also proposed. This provides a significant improvement in the signal-to-noise ratio in the measurement implementation of the signal of fluctuations in the speed of the crankshaft. An analytical expression for the cross-correlation function between the time realization of the fluctuation signal and the torque of the first cylinder is obtained. The scheme of the algorithm for monitoring of identity of cylindrical powers of the power unit is developed. The uncertainty of information technology for processing indirect measurement data is investigated and the requirements for metrological characteristics of hardware for measuring the signal of the instantaneous crankshaft speed signal are established.
Adaptasi Lembaga Pendidikan Non Formal dalam Menghadapi Tantangan Pandemi Covid-19
Authors: Apriyansyah Yusuf  , Meila Riskia Fitri
Published: July 2022

Tujuan penelitian ini untuk mendeskripsikan keadaan Bimbel SG Cibubur sebelum dan pada saat situasi Pandemi Covid-19, mengetahui adaptasi yang dilakukan oleh Bimbel SG Cibubur, serta mengetahui respon yang terjadi pada manajemen dan karyawan dengan adanya adaptasi baru di masa Pandemi Covid-19. Dalam penelitian ini peneliti menggunakan pendekatan kualitatif dengan metode studi kasus. Data penelitian diperoleh melalui wawancara mendalam, observasi, dan dokumentasi. Subjek penelitian adalah 3 orang sebagai informan kunci, 2 orang sebagai informan utama, 2 Orang sebagai informan yang dibutuhkan untuk triangulasi data. Wawancara dilakukan secara langsung sejak bulan Juni – Agustus  2021. Hasil penelitian ini berupa adaptasi yang dilakukan oleh Bimbel SG Cibubur, maupun subjek penelitian yang juga terlibat dalam adaptasi di masa Pandemi Covid-19. Adaptasi yang dilakukan berkaitan dengan pembelajaran offline yang diubah menjadi online. Lebih dalam lagi, dalam penelitian adaptasi Bimbel SG Cibubur, peneliti menganalisis hasil temuan dengan Teori Struktural Fungsional Talcott Parson dengan pendekatan AGIL. Ditemukan bahwa adaptasi yang dilakukan oleh bimbel terlihat dalam indikator Adaptation sehingga dapat tercapainya keteraturan sosial dengan segala adaptasi di masa Pandemi Covid-19.
Using Geophysical and Erosion Properties to Identify Potential Beneficial Use Applications for Atlantic Intracoastal Waterway Sediments
Authors: Perkey David W. , Tarpley Danielle R. N. , Styles Renée M.
Published: July 2022

In an effort to identify alternative and beneficial use placement strategies for dredged sediments from the Atlantic Intracoastal Waterway (AIWW), the US Army Corps of Engineers, Savannah District (SAS), and the US Army Engineer Research and Development Center (ERDC) performed a series of physical property tests of 34 core borings from the SAS AIWW. Physical property testing found that 14 of the borings were non-cohesive sandy materials that may be suitable for potential beach renourishment or berm construction. The remaining 20 borings had mud contents sufficient enough to result in cohesive behavior. A subset of six of these materials from across the geographic region were further evaluated to characterize their erosion behavior. Following a self-weight consolidation period of 30 days, erosion testing showed that the tested cohesive sediments had critical shear stress values that ranged from 1.7 Pa to 2.9 Pa, suggesting that these sediments would likely be resistant to erosion in most wetland environments after placement. Additionally, the cohesive sediments were found to produce gravel-sized mud clasts. These clasts could account for 20% or more of the eroded mass and significantly reduce the amount of silts and clays incorporated in suspended plumes during and immediately following placement.
Taxonomy of the fossil calcareous algae: Revision of genera Physoporella Steinmann and Oligoporella Pia (Dasycladales)
Authors: Grgasović Tonći
Published: July 2022

The taxonomic classification and mutual distinction of the genera Physoporella Steinmann and Oligoporella Pia (Dasycladales, green algae) have proven problematic and that has impeded their use in stratigraphy and other studies. The presence of single whorls of piriform laterals in Physoporella and double whorls in Oligoporella is considered as the main characteristic that separates these genera. According to that, diagnoses of genera and all species and varieties are changed or supplemented, and detailed descriptions are given. For this purpose the type-material from Pia's collection was re-examined and its redocumentation and reinterpretation performed. Additional information was obtained from abundant material from Croatia (Ivanščica Mt, Medvednica Mt, Žumberak Mt, Lika, Dalmatia). Only a few taxa were examined based on literature data. For all species and varieties reconstructions are given. Taxa from the Permian of East Asia are only briefly described. Among the investigated taxa, some of them have a structure that significantly differs from that present in the type species of the genera Physoporella and Oligoporella. They are separated into two new genera Ardeiporella and Neophysoporella. The revised genera Physoporella and Oligoporella, together with the newly established ones, give a clearer picture of phylogenetic relations.
The Kalkowsky Project - Chapter IV. Case study of the Happy Spraberry oil reservoirs in NW Texas (with a micropaleontologic and biostratigraphic supplement): Collapsed molds should not be treated as a category of distorted ooids
Authors: Granier Bruno , Kendall Christopher G. St. , Vachard Daniel
Published: July 2022

The subsurface upper Spraberry Formation in NW Texas is dominantly composed of calcareous turbidites and debris-flows. The petrographic analysis of its porous grain-supported fabrics revealed the presence of controversial superimposed compaction fabrics, sometimes referred to as "distorted ooids". Based on the paragenetic sequence, it is demonstrated that these allochems were not distorted. In fact, the related zigzag and silcrow (§) patterns result from the collapse of molds, either oomolds or biomolds, in response to mechanical compaction of the fragile framework made up of isopachous Low-Mg Calcite cement surrounding these empty molds. As a side finding, this stratigraphic unit, which was said to be late Kungurian in age, is proved to be nearly 7 millions of year older.
Priabonian non-geniculate coralline algae from the Central Carpathian Paleogene Basin
Authors: Hrabovský Juraj , Starek Dušan
Published: July 2022

Encrusting coralline algae are important rock-building organisms of the lower Priabonian limestones from the Central Carpathian Paleogene Basin. Despite the effort of early palaeontologists, former classifications lacked many diagnostic characteristics and modern taxonomic concepts, which hinders their use for modern palaeontological interpretations. The situation is further complicated as recent DNA analyses of extant coralline algae highlight the limits of the morpho-anatomical classification and identify many coralline algal genera which can also be recognized in the fossil record. Because palaeontology deals exclusively with the morpho-anatomical characteristics, a synthesis of the new discoveries in molecular phylogenetic analyses with morphology-based palaeontological classifications is necessary. Our palaeontological study based on published investigations on coralline molecular genetics enabled: 1) the identification of seventeen coralline algal morphological species grouped in six genera: Sporolithon lugeonii, Sporolithon nummuliticum, Sporolithon sp. 1, Sporolithon sp. 2, Lithothamnion camarasae, Lithothamnion cf. corallioides, Lithothamnion prascoi, Lithothamnion cf. ramosissimum, Lithothamnion roveretoi, Lithothamnion sp., Phymatolithon sp., Mesophyllum fructiferum, Mesophyllum cf. engelhartii, Mesophyllum sp., Chamberlainium lemoinei, Lithoporella melobesioides, and Lithoporella cf. minus ; 2) the description of Chamberlainium lemoinei (Miranda) comb. nov. known from the Bartonian, and 3) the identification of a unique encrusting coralline alga tentatively assigned to the genus Lithothamnion.
Palaeosedimentary Environment and Formation Mechanism of High-Quality Xujiahe Source Rocks, Sichuan Basin, South China
Authors: Xu Kun , Chen Shijia , Lu Jungang , Li Yong , Zhu Xingcheng , Liu Jihua , Wu Xueting , Li Chen
Published: July 2022

Triassic Xujiahe source rocks, the main gas source of shallow tight gas, are the most typical continental coal-bearing source rocks in the Sichuan Basin, South China. However, the organic matter enrichment section cannot be identified easily, leading to limited progress in the exploration of coal-bearing tight gas. This paper reveals the main controlling factors of the organic matter enrichment, reconstructs the evolution process of the Xujiahe palaeosedimentary environment, proposes a dynamic enrichment mechanism of the organic matter, and determines the organic matter enrichment section of the high-quality coal-bearing source rocks by geochemical characteristics of the source rocks, major elements, and trace elements. The results show that the Xujiahe sedimentary environment can be divided into a fluctuating stage of transitional sedimentation, stable stage of transitional sedimentation, fluctuating stage of continental sedimentation, and stable stage of continental sedimentation. The Xujiahe source rocks were featured with high-quality coal-bearing source rocks with high total organic carbon and maturity and good parent material in the stable stage of transitional sedimentation and fluctuating stage of continental sedimentation, in which the water was connected with the Palaeo-Tethys Ocean with abundant terrestrial organisms. The water was shallow in the fluctuating stage of transitional sedimentation with a low sedimentation rate, leading to poor organic matter enrichment. The Palaeo-Tethys Ocean withdrew westward from the Yangtze plate in the late period of the fluctuating stage of continental sedimentation, leading to the absence of algae and dinosteranes and a decrease in biological productivity in the stable stage of continental sedimentation. Therefore, high terrestrial inputs and biological productivity and high sedimentation rate were conducive to the organic matter preservation in the coal-bearing source rocks.