bluuebunny/crossref_metadata_2025 huggingface dataset:
Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study
Authors: Darwish Noura M. , Elshaer Mohamed M. A. , Almutairi Saeedah Musaed , Chen Tse-Wei , Mohamed Mohamed Othman , Ghaly Wael B. A. , Rasheed Rabab Ahmed
Published: May 2022

Hepatocellular carcinoma (HCC) is a common type of liver cancer and is a leading cause of death worldwide. Signal transducer and activator of transcription 3 (STAT3) is involved in HCC progression, migration, and suppression of apoptosis. This study investigates the apoptotic effect of the dietary antioxidant (n-3 PUFAs) on HepG2 cells and analyzes the underlying molecular mechanisms of this effect both in vivo and in vitro. In vivo study: Seventy-five adult male albino rats were divided into three groups (n = 25): Group I (control): 0.9% normal saline, intraperitoneal. Group II: N-Nitrosodiethylamine (200 mg/kg b.wt) intraperitoneal, followed by phenobarbital 0.05% in drinking water. Group III: as group II followed by n-3 PUFAs intubation (400 mg/kg/day). In vivo study: liver specimens for biochemical, histopathological, and immunohistochemical examination. In vitro study: MTT assay, cell morphology, PCR, Western blot, and immunohistochemical analysis. n-3 PUFAs significantly improved the histopathologic features of HCC and decreased the expression of anti-apoptotic proteins. Further, HepG2 cells proliferation was suppressed through inhibition of the STAT3 signaling pathway, cyclin D1, and Bcl-2 activity. Here we report that n-3 PUFAs may be an ideal cancer chemo-preventive candidate by targeting STAT3 signaling, which is involved in cell proliferation and apoptosis.
Beta-Carotene Affects the Effects of Heme Oxygenase-1 in Isolated, Ischemic/Reperfused Rat Hearts: Potential Role of the Iron
Authors: Csepanyi Evelin , Gyongyosi Alexandra , Lekli Istvan , Tosaki Arpad , Bak Istvan
Published: May 2022

Beta-carotene (BC) is a well-known antioxidant. However, increasing evidence shows that under severe oxidative conditions, BC can become pro-oxidant, an effect that may be enhanced in the presence of iron (II). In our earlier studies, we observed that despite increasing heme oxygenase-1 (HO-1) levels in the heart, the protective effects of BC have been lost when it was used at a high concentration. Since iron releases from heme as a consequence of HO-1 activity, we hypothesized that the application of an iron-chelator (IC) would reverse the lost cardiac protection associated with an elevated HO-1 level. Thus, in the present study, we investigated the effects of desferrioxiamine (DFO) in isolated, ischemic/reperfused rat hearts after long-term treatment with vehicle or high-dose (HD) BC. Vehicle or 150 mg/bw kg daily doses of BC were administered to the rats for 4 weeks, and then their hearts were removed and subjected to 30 min of global ischemia (ISA) followed by 120 min of reperfusion (REP). During the experiments, cardiac function was registered, and at the end of the REP period, infarct size (IS) and HO-1 expression were measured. The results show that DFO treatment alone during REP significantly ameliorated postischemic cardiac function and decreased IS, although HO-1 expression was not increased significantly. In hearts isolated from BC-treated rats, no cardioprotective effects, despite an elevated HO-1 level, were observed, while DFO administration after ISA resulted in a mild improvement in heart function and IS. Our results suggest that iron could have a role whether BC exerts antioxidant or pro-oxidant effects in ISA/REP-injured hearts.
Nano-Graphene Layer from Facile, Scalable and Eco-Friendly Liquid Phase Exfoliation Strategy as Effective Barrier Layer for High-Performance and Durable Direct Liquid Alcohol Fuel Cells
Authors: Balakrishnan Prabhuraj , Sanij Fereshteh Dehghani , Chang Zhixin , Leung P. K. , Su Huaneng , Xing Lei , Xu Qian
Published: May 2022

Graphene, in spite of exceptional physio-chemical properties, still faces great limitations in its use and industrial scale-up as highly selective membranes (enhanced ratio of proton conductivity to fuel cross-over) in liquid alcohol fuel cells (LAFCs), due to complexity and high cost of prevailing production methods. To resolve these issues, a facile, low-cost and eco-friendly approach of liquid phase exfoliation (bath sonication) of graphite to obtain graphene and spray depositing the prepared graphene flakes, above anode catalyst layer (near the membrane in the membrane electrode assembly (MEA)) as barrier layer at different weight percentages relative to the base membrane Nafion 115 was utilized in this work. The 5 wt.% nano-graphene layer raises 1 M methanol/oxygen fuel cell power density by 38% to 91 mW·cm−2, compared to standard membrane electrode assembly (MEA) performance of 63 mW·cm−2, owing to less methanol crossover with mild decrease in proton conductivity, showing negligible voltage decays over 20 h of operation at 50 mA·cm−2. Overall, this work opens three prominent favorable prospects: exploring the usage of nano-materials prepared by liquid phase exfoliation approach, their effective usage in ion-transport membrane region of MEA and enhancing fuel cell power performance.
Coastal Quarries as Relative Sea-Level Markers: A Methodological Approach Applied in the Apulia Region (Southern Italy)
Authors: Scardino Giovanni , Piscitelli Arcangelo , Locuratolo Giuseppe , Scicchitano Giovanni , Rizzo Angela
Published: May 2022

The assessment of past sea-level positions requires a multidisciplinary approach that involves both scientific and historical humanistic fields. The use of a multidisciplinary approach allows us to obtain reliable information on the relative sea-level position, the determination of which requires the evaluation of the eustatic and steric components as well as an assessment of the vertical ground displacements, such as the isostatic adjustments and tectonic movements. In this context, coastal geoarchaeological markers play a fundamental role since their architectural height (generally defined as functional height) was relative to the sea level at the time of their construction. Thus, a comparison between the current elevation of geoarchaeological structures (or depth in the case they are currently submerged) with their estimated functional height allows us to obtain the relative sea-level variation. In this study, we applied a methodological procedure for the evaluation of the functional height of architectural elements using modern technologies (Terrestrial Laser Scanner and GPS-Real Time Kinematic) and detailed sea-level analysis. The proposed methodology was applied to coastal quarries located along the coast of Bari (Apulia region, southern Italy). The results allowed us to confirm the functional height of the detachment surface reported in the literature and to assess the sea-level position in the fifth and fourth centuries before Christ.
Pathological Studies and Postmortem Computed Tomography of Dolphins with Meningoencephalomyelitis and Osteoarthritis Caused by Brucella ceti
Authors: Granados-Zapata Andrés , Robles-Malagamba María José , González-Barrientos Rocío , Kot Brian Chin-Wing , Barquero-Calvo Elías , Cordero-Chavaría Minor , Suárez-Esquivel Marcela , Guzmán-Verri Caterina , Palacios-Alfaro Jose David , Tien-Sung Connie , Moreno Edgardo , Hernández-Mora Gabriela
Published: May 2022

Cetacean neurobrucellosis is a common cause of strandings in Costa Rica diagnosed by serology, bacteriology, and histopathology. Pathological studies were performed on 18 dolphins. Twelve were scanned by postmortem computed tomography (PMCT) as a complementary tool for describing neurobrucellosis and osteoarticular alterations associated with Brucella ceti infections. The central nervous system (CNS) and the skeleton of five dolphins not infected with B ceti did not reveal alterations by PMCT scanning. Seven Brucella-infected dolphins showed at least bilateral ventriculomegaly associated with hydrocephalus and accumulation in CSF in the lateral ventricles. We performed semiquantitative grading of the inflammatory process in the different areas of the CNS and evaluated the thickness of the cellular infiltrate in the meninges and the perivascular cuffs. The results for the severity grading were graphed to provide an injury profile associated with each area of the CNS. Age is not a decisive factor regarding neurobrucellosis presentation. The severity of ventriculomegaly by PMCT does not directly correlate with the severity of the inflammatory index determined by histopathological parameters of the brain cortex and other CNS regions, suggesting that these processes, although linked, are multifactorial and need further characterization and validation to establish better cutoffs on the PMCT.
Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking
Authors: Yıldırım Hatice , Yıldız Mahmut , Bayrak Nilüfer , Mataracı-Kara Emel , Radwan Mohamed Osman , Jannuzzi Ayse Tarbin , Otsuka Masami , Fujita Mikako , TuYuN Amaç Fatih
Published: May 2022

In the present study, we designed and synthesized thiolated VK3 analogs (VK3a–g) along with an extensive antimicrobial study. After the evaluation of the antibacterial and antifungal activity against various bacterial and fungal strains, we presented an initial structure–activity relationship study on these VK3 analogs. In particular, four thiolated VK3 analogs exhibited superior biological potency against some Gram-positive bacterial strains, including Staphylococcus aureus (ATCC® 29213) and Enterococcus faecalis (ATCC® 29212). Next, all thiolated VK3 analogs were evaluated for their potential of cell growth inhibition on the NCI-60 cancer cell lines panel. This screening underlined that the thiolated VK3 analogs have no visible cytotoxicity on different cancer cell lines. The selected two thiolated VK3 analogs (VK3a and VK3b), having minimal hemolytic activity, which also have the lowest MIC values on S. aureus and E. faecalis, were further evaluated for their inhibition capacities on biofilm formation after evaluating their potential in vitro antimicrobial activity against each of the 20 clinically obtained resistant strains of Staphylococcus aureus. VK3b showed excellent antimicrobial activity against clinically resistant S. aureus isolates. Furthermore, the tested molecules showed nearly two log10 reduction in the viable cell count at six hours according to the time kill curve studies. Although these molecules decreased biofilm attachment about 50%, when sub-MIC concentrations were used these molecules increased the percentage of biofilm formation. The molecular docking of VK3a and VK3b in S. aureus thymidylate kinase was conducted in order to predict their molecular interactions. VK3a and VK3b exhibited excellent lead-likeness properties and pharmacokinetic profiles that qualify them for further optimization and development. In conclusion, since investigating efficient novel antimicrobial molecules is quite difficult, these studies are of high importance, especially in the present era of antimicrobial resistance.
Target Mechanism of Iturinic Lipopeptide on Differential Expression Patterns of Defense-Related Genes against Colletotrichum acutatum in Pepper
Authors: Park Joon Seong , Ryu Gwang Rok , Kang Beom Ryong
Published: May 2022

Bacillus subtilis KB21 is an isolate with broad spectrum antifungal activity against plant pathogenic fungi. Our aim was to produce and purify antifungal lipopeptides via fermentation using B. subtilis KB21 and verify their antifungal mechanism against pepper anthracnose. When the KB21 strain was cultured in tryptic soy broth medium, the antifungal activity against pepper anthracnose correlated with biosurfactant production. However, there was no antifungal activity when cultured in Luria-Bertani medium. KB21 filtrates showed the highest degree of inhibition of mycelia (91.1%) and spore germination (98.9%) of Colletotrichum acutatum via increases in the biosurfactant levels. Using liquid chromatography-mass spectrometry (LC-MS) and LC-tandem MS (LC-MS/MS) analyses, the component with antifungal activity in the fermentation medium of the KB21 strain was determined to be the cyclic lipopeptide (CLP) antibiotic, iturin A. When the iturin fractions were applied to pepper fruits inoculated with conidia of C. acutatum, the lesion diameter and hyphal growth on the fruit were significantly suppressed. In addition, iturin CLP elevated the gene expression of PAL, LOX, and GLU in the treatments both with and without following fungal pathogens. Overall, the results of this study show that iturin CLPs from B. subtilis KB21 may be potential biological control agents for plant fungal diseases.
Selenium, Sulfur, and Methyl Jasmonate Treatments Improve the Accumulation of Lutein and Glucosinolates in Kale Sprouts
Authors: Ortega-Hernández Erika , Antunes-Ricardo Marilena , Cisneros-Zevallos Luis , Jacobo-Velázquez Daniel A.
Published: May 2022

Kale sprouts contain health-promoting compounds that could be increased by applying plant nutrients or exogenous phytohormones during pre-harvest. The effects of selenium (Se), sulfur (S), and methyl jasmonate (MeJA) on lutein, glucosinolate, and phenolic accumulation were assessed in kale sprouts. Red Russian and Dwarf Green kale were chamber-grown using different treatment concentrations of Se (10, 20, 40 mg/L), S (30, 60, 120 mg/L), and MeJA (25, 50, 100 µM). Sprouts were harvested every 24 h for 7 days to identify and quantify phytochemicals. The highest lutein accumulation occurred 7 days after S 120 mg/L (178%) and Se 40 mg/L (199%) treatments in Red Russian and Dwarf Green kale sprouts, respectively. MeJA treatment decreased the level of most phenolic levels, except for kaempferol and quercetin, where increases were higher than 70% for both varieties when treated with MeJA 25 µM. The most effective treatment for glucosinolate accumulation was S 120 mg/L in the Red Russian kale variety at 7 days of germination, increasing glucoraphanin (262.4%), glucoerucin (510.8%), 4-methoxy-glucobrassicin (430.7%), and glucoiberin (1150%). Results show that kales treated with Se, S, and MeJA could be used as a functional food for fresh consumption or as raw materials for different industrial applications.
Effects of Non-Ionic Micelles on the Acid-Base Equilibria of a Weak Polyelectrolyte
Authors: Yekymov Evgenee , Attia David , Levi-Kalisman Yael , Bitton Ronit , Yerushalmi-Rozen Rachel
Published: May 2022

Weak polyelectrolytes (WPEs) are widely used as pH-responsive materials, pH modulators and charge regulators in biomedical and technological applications that involve multi-component fluid environments. In these complex fluids, coupling between (often weak) interactions induced by micelles, nanoparticles and molecular aggregates modify the pKa as compared to that measured in single component solutions. Here we investigated the effect of coupling between hydrogen bonding and excluded volume interactions on the titration curves and pKa of polyacrylic acid (PAA) in solutions comprising PEO-based micelles (Pluronics and Brij-S20) of different size and volume fraction. Titration experiments of dilute, salt-free solutions of PAA (5 kDa, 30 kDa and 100 kDa) at low degree of polymer ionization (α < 0.25) drive spatial re-organization of the system, reduce the degree of ionization and consequentially increase the pKa by up to ~0.7 units. These findings indicate that the actual degree of ionization of WPEs measured in complex fluids is significantly lower (at a given pH) than that measured in single-component solutions.
Effect of Embedded Thin-Plies on the Charpy Impact Properties of CFRP Composites
Authors: Alshahrani Hassan , Sebaey Tamer A.
Published: May 2022

In this study, different configurations of epoxy composite laminates that contained thin plies were prepared and characterised for sudden impact load bearing applications. The primary aim of this investigation was to develop a hybrid epoxy-based thin ply composite for aerospace and automotive applications that would be tolerant of high impacts. The impact properties of the selected configurations were investigated both experimentally and numerically under low-velocity Charpy impact loading conditions. Furthermore, any damage to the laminates was evaluated with an emphasis on the identification of dominant damage mechanisms and locations. This included a comparison between the laminates that were made from traditional plies and the thin ply laminates in terms of their absorbed energy and failure modes. The results revealed that the integration of thin plies into normal ply had a major effect on the amount of absorbed energy under flatwise conditions: up to 8.7 J at a cut-off angle of 90°. However, edgewise conditions produced a maximum observed energy of 10.0 J for the thin plies that were surrounded by normal plies (Plate 3). The damage assessments showed the increased damage resistance of the hybrid thin ply composites due to their uniform stress distribution. The traditional ply composites incurred large deformations from the impact loads. Moreover, it was noted that delamination formed in the middle regions of the traditional plies. The FEM model analysis revealed that it was capable of accurately predicting the absorbed energy for different configurations of composites, which were prepared and analysed experimentally. Both the experimental and numerical values were very similar to each other. These impact damage assessments improved the thin ply composites so that they could be used as working materials for applications that are prone to high loads, such as the aerospace, defence, automotive and structural industries.
Applications of Proteomics in Ovarian Cancer: Dawn of a New Era
Authors: Ghose Aruni , Gullapalli Sri Vidya Niharika , Chohan Naila , Bolina Anita , Moschetta Michele , Rassy Elie , Boussios Stergios
Published: May 2022

The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The patients present an advanced stage at diagnosis. This heterogeneous disease has distinguishable etiology and molecular biology. Next-generation sequencing changed clinical diagnostic testing, allowing assessment of multiple genes, simultaneously, in a faster and cheaper manner than sequential single gene analysis. Technologies of proteomics, such as mass spectrometry (MS) and protein array analysis, have advanced the dissection of the underlying molecular signaling events and the proteomic characterization of OC. Proteomics analysis of OC, as well as their adaptive responses to therapy, can uncover new therapeutic choices, which can reduce the emergence of drug resistance and potentially improve patient outcomes. There is an urgent need to better understand how the genomic and epigenomic heterogeneity intrinsic to OC is reflected at the protein level, and how this information could potentially lead to prolonged survival.
Identification of Coupling Relationship between Ecosystem Services and Urbanization for Supporting Ecological Management: A Case Study on Areas along the Yellow River of Henan Province
Authors: Wei Hejie , Xue Dong , Huang Junchang , Liu Mengxue , Li Ling
Published: May 2022

Urbanization has an important effect on ecosystem services (ESs) and identifying the relationship between urbanization and ESs can provide a decision-making reference for regional ecological protection and management. Taking the areas along the Yellow River of Henan Province (AYRHP) as a research area, a coupling system of ESs and urbanization is established in this study to reveal the coupling relationship between the two. ESs are estimated by using Carnegie–Ames–Stanford approach, revision universal soil loss equation, and Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) models. The urbanization level is evaluated from three dimensions, namely, population, economy, and land. The coupling coordination relationship between various ESs and urbanization in AYRHP is quantified from 2000 to 2018 on the county scale based on the coupling coordination degree (CCD) model. The lead–lag relationship between ESs and urbanization is identified by using the relative development degree model, and ecological management zoning is conducted. Results show that in the study period, net primary production (NPP), soil conservation, and food production are increased, whereas water yield is decreased. In the study period, population, economy, and land urbanization level are increasing, and the comprehensive urbanization level is increased by 51.63%. The total CCD between NPP, food production, and water yield and comprehensive urbanization is basic or moderate coordination, whereas that between soil conservation and comprehensive urbanization is moderate maladjustment. In the research period, the coupling coordination between NPP and food production and comprehensive urbanization is increasing; that between water yield and comprehensive urbanization is fluctuated; and that between soil conservation and comprehensive urbanization is decreasing. The result of the research into the relative development degree in 2018 showed that food production, water yield, and soil conservation lag behind the urbanization level in most regions and counties along the Yellow River of Henan Province. On the basis of the lead–lag relationship between different ESs and urbanization level, the AYRHP are divided into ecological reconstruction area, ecological and agricultural improvement area, and ecological conservation area. CCD and relative development degree models can be used to evaluate the coordination relationship between ESs and urbanization, which provides scientific support for regional ES management.
Durability Analysis of Building Exterior Thermal Insulation System in Hot Summer and Cold Winter Area Based on ANSYS
Authors: Huang Zhijia , Sun Yadong , Gan Lin , Liu Guo , Zhang Yang , Zhou Tao
Published: May 2022

External thermal insulation systems often have durability problems, including cracking, hollowing, and falling off, which seriously affect safety and energy-saving effects. Based on finite element theory and using ANSYS software, this paper studies the distribution law of the temperature field and temperature stress of the external thermal insulation system. It was found that, compared with an uninsulated wall, the temperature stress of the substrate in summer was reduced by 52.9%, and the temperature stress of the substrate in winter was reduced by 50.9%. The temperature stress is mainly concentrated in the middle position of the external wall insulation system, and the middle of the wall can appear as a hollow drum and fall off. When the temperature of the external wall surface is 60 °C, the maximum temperature stress of the insulation system is 2.46 MPa, compared with the external wall surface of 70 °C—a decrease of 22.2%; the maximum temperature stress on the substrate is 0.46 MPa—a decrease of 20.7%. When the temperature of the outer wall surface is 50 °C, the maximum temperature stress suffered by the insulation system is 1.75 MPa, compared with the outer wall surface of 70 °C—a decrease of 44.4%. Meanwhile, the maximum temperature stress suffered by the substrate is 0.34 MPa—a decrease of 41.4%. This paper investigates and numerically simulates the durability of external wall insulation systems for buildings in hot summer and cold winter regions, and studies the durability of EPS insulation, which can provide guidance for other insulation material design and durability studies.
The Spatiotemporal Characteristics of Water Quality and Main Controlling Factors of Algal Blooms in Tai Lake, China
Authors: Xu Ruichen , Pang Yong , Hu Zhibing , Hu Xiaoyan
Published: May 2022

Taking Tai Lake in China as the research area, a 3D water environment mathematical model was built. Combined with the LHS and Morris uncertainty and sensitivity analysis methods, the uncertainty and sensitivity analysis of total phosphorus (TP), total nitrogen (TN), dissolved oxygen (DO), and chlorophyll a (Chl-a) were carried out. The main conclusions are: (1) The performance assessment of the 3D water environment mathematical model is good (R2 and NSE > 0.8) and is suitable for water quality research in large shallow lakes. (2) The time uncertainty study proves that the variation range of Chl-a is much larger than that of the other three water quality parameters and is more severe in summer and autumn. (3) The spatial uncertainty study proves that Chl-a is mainly present in the northwest lake area (heavily polluted area) and the other three water quality indicators are mainly present in the center. (4) The sensitivity results show that the main controlling factors of DO are ters (0.15) and kmsc (0.12); those of TN and TP are tetn (0.58) and tetp (0.24); and those of Chl-a are its own growth rate (0.14), optimal growth temperature (0.12), death rate (0.12), optimal growth light (0.11), and TP uptake rate (0.11). Thus, TP control is still the key treatment method for algal blooms that can be implemented by the Chinese government.
From Theory to Practice: The Student Experience Evaluating Development Projects Focused on Nature-Based Solutions
Authors: Bierbaum Rosina , Lazaroff Marissa
Published: May 2022

Graduate students often seek hands-on experiences in the international development field. Given that Multilateral Development Banks (MDBs) provide hundreds of billions of dollars in aid each year, we expected that reviewing the design, implementation, and outcomes of their environmental projects would provide valuable learning outcomes for students. This novel study on Nature-based Solutions (NbS) in the Global Environment Facility (GEF) gave students the opportunity to engage directly with practitioners in the review of 50 environmental projects across 45 countries. A team of professionals from the Scientific and Technical Advisory Panel (STAP) of the GEF and eight students from the University of Michigan School for Environment and Sustainability and the University of Maryland School of Public Policy developed lessons learned from reviewing the GEF portfolio over a twenty-year time span. When screening projects for enabling conditions including theory of change, climate risk screening, multi-stakeholder engagement, and adaptive management, most had stronger explanations of the environmental than the social outcomes sought, and only more recent ones incorporated climate risk screening. The process and findings associated with this educational experience contributed to students’ climate change leadership development; for example, by learning about the tradeoffs and possible co-benefits of improving both environmental conditions and livelihoods in less developed countries. Our research led to practice advice for the design of future GEF projects, as well as ideas for future coursework to further bridge the gap between theory and practice in academia, which we believe to be essential to preparing the next generation of climate leaders.
Mechanical and Durability Assessment of Recycled Waste Plastic (Resin8 & PET) Eco-Aggregate Concrete
Authors: Babafemi Adewumi John , Sirba Nina , Paul Suvash Chandra , Miah Md Jihad
Published: May 2022

The massive amount of plastic waste in our natural environment is a global concern. In this study, recycling plastic waste to partially replace natural sand in concrete is investigated. The performance of Resin8, a unique combination of all types of plastics and Polyethylene Terephthalate (PET) in concrete, has also been investigated. Replacement contents of 5%, 10%, and 15% for sand by volume were performed. The concrete mixes incorporating recycled plastic waste were tested against a reference concrete mix without plastic. The workability, compressive strength, tensile strength, oxygen permeability index (OPI), and effect of temperature were assessed. Scanning Electron Microscopy (SEM) analysis was conducted on the plastics and plastic concretes, pre- and post-temperature exposure. PET at a replacement content of 10% slightly increased the compressive strength by 2.4%. Regarding the OPI test, all the mixes incorporating recycled plastic waste are classified as “good”. When exposed to a temperature of 250 °C, no significant change in compressive strength was observed for the concrete mixes incorporating Resin8 at a replacement content of 15%, and the mixes incorporating PET at a replacement content of 5%, 10%, and 15%. It was clear from the results that both Resin8 and PET are suitable as a partial replacement for sand in concrete.
Indicators of Sustainable Employability among Older Finnish Postal Service Employees: A Longitudinal Study of Age and Time Effects
Authors: Neupane Subas , Kyrönlahti Saila , K.C. Prakash , Siukola Anna , Kosonen Hanna , Lumme-Sandt Kirsi , Nikander Pirjo , Nygård Clas-Håkan
Published: May 2022

We first clarify the definition of sustainable employability, and then we study how the indicators of sustainable employability among older Finnish postal service employees have changed over time. Finally, we estimate the effect of age on these indicators in a two-year follow up. A questionnaire survey among the Finnish postal service employees was conducted in 2016, and a follow-up was conducted in 2018. We analyze data from 1262 subjects who replied to both the baseline and the follow-up surveys. Sustainable employability is defined as a multidimensional construct using nine indicators and covering three domains (health, well-being and employability) based on Fleuren and colleagues’ model. Measurement time (repeated measure) is used as a within-subjects factor, and age is used as a between-subjects factor. The estimated marginal means of the indicators of sustainable employability at the baseline and the follow-up by age in years are calculated. No significant change is found in eight indicators (work ability, time and resources, recovery after work, job satisfaction, motivation, perceived employment, enough training on the job and relevance of work) of sustainable employability after the two-year follow-up. We find a statistically significant effect of time on self-rated health (F = 6.56, p = 0.011). Six out of nine indicators (self-rated health, work ability, time and resources, recovery after work, job satisfaction, and perceived employment) have a statistically significant effect of age between subjects. Partial Eta Squared (ŋ2p) shows a very small difference in the indicators of sustainable employability during the follow-up, indicating that the employability of the workers was sustained throughout. We used the Fleuren model as the basis for our definition of sustainable employability. Although they are based on single items, these indicators of sustainable employability remain stable after the two-year follow-up. Significant effects of age between subjects are found for six out of nine indicators. The results suggest that age may be an important determinant of sustainable employability.
Stock Status of Whitespotted Bambooshark, Chiloscyllium plagiosum (Anonymous [Bennett], 1830) in Sabah, Malaysia, Using Yield-Per-Recruit and Spawning Per-Recruit Analyses
Authors:   Graduate School of Fisheries Science, Hokkaido University, Hakodate, Hokkaido, Japan, PATTARAPONGPAN SUPAPONG , ARNUPAPBOON SUKCHAI , ARSHAD ABDUL HARIS HILMI BIN AHMAD , MATSUISHI TAKASHI FRITZ
Published: May 2022

Whitespotted bambooshark, Chiloscyllium plagiosum (Anonymous [Bennett], 1830), is a major shark species caught in waters off Sabah, Malaysia. Despite the massive landing amount, its biological and stock status information is limited. In 2015–2016, the elasmobranch data collection was conducted in Southeast Asia, including Sabah. A yield-per-recruit (YPR) and spawning-per-recruit (SPR) analyses were performed to assess this data-deficient species’ stock status. The growth parameter, average maximum length, L∞, and growth rate, K, for males and females were 81.13 cm and 0.21 year-1 , and 84.30 cm and 0.18 year-1 , respectively. Limit and target biological reference points, maximum fishing mortality and fishing mortality corresponding to 10 % of YPR slope (Fmax and F0.1, respectively) for YPR, and fishing mortality corresponding to 20 % and 30 % of spawning stock remained (F20% and F30%, respectively) for SPR, were calculated. The results suggest neither growth nor recruit overfishing was occurring. Monitoring and surveillance of existing management measures are necessary to ensure sustainable utilisation of the stock.
PENGARUH BUKU SAKU GIZI KESEHATAN REPRODUKSI TERHADAP MINAT PENCEGAHAN ANEMIA PADA WANITA PEKERJA
Authors: Mamat Mamat , Mardianti Mardianti
Published: May 2022

Penyebab terjadinya kasus anemia terjadinya karena kurang pengetahuan. Media buku saku merupakan salah satu alternafir memenuhi kebutuhan kekurangan pengetahuan  . Tujuan penelitian ini mengetahui pengaruh buku saku gizi kesehatan reproduksi terhadap persepsi perilaku, norma subyektif, sikap dan  minat perilaku pencegahan anemia pada wanita pekerja. Desain yang digunakan adalah quossi eksperimen dengan control grup. Sampelnya wanita pekerja diambil secara pupossive random sampling. Besar sampel sebanyak 119 terbagi dalam 2 kelompok yaitu kelompok intervensi (54 sampel) dan dan 65 sampel sebagai kelompok kontrol. Buku saku yang digunakan untuk intervensi telah disusun dan dikaji berdasarkan kebutuhan serta kajian ahli. Data yang dikumpulkkan mengacu pada teori Theory of Planded Behavior (TPB),  diambil secara online meliputi perpesi kendali perilaku, norma subyektif dan sikap serta minat perilaku pencegahan anemia. Data diolah dengan program SPPS lalu dianalisis dengan uji t independent  hasilnya menunjukkan terdapat pengaruh buku saku terhadap  persepsi kendali perilaku, norma subyektif dan sikap,   yang tergambar beda nilai rata rata  persepsi kendali perilaku lebih besar pada kelompok intervensi 1,56 poin ,  norma subyektif sebesar  2,2 poin dan  skor sikap sebesar 3,0 poin dibanding kelompok kontrol dimana ketiganya memiliki  nilai p  0,01. Terdapat pengaruh buku saku terhadap minat dengan perbedaan rata rata minat minat  sebesar 1,33 poin lebih besar kelompok intervensi dibanding kelompok kontrol dengan nilai p sebesar 0,001. Mengacu pada hasil pengembangan media perlu ditingkatkan dalam bentuk online seperti E-book dan media informasi lainnya serta perlu ada kolaborasi dan kordinasi dengan intansi terkait
EFEKTIVITAS PEMBERIAN SNACK BAR TAPE KETAN HITAM TERHADAP FREKUENSI DEFEKASI PADA REMAJA PUTRI
Authors: Rahayu Seni , Wardani Sri Wisnu , Mulyo Gurid PE
Published: May 2022

Kesehatan saluran reproduksi remaja penting untuk diperhatikan karena turut menentukan kesehatan reproduksi remaja di masa yang akan datang. Remaja cenderung mengkonsumsi makanan tinggi energy namun rendah serat. Hal ini akan mencetuskan berbagai permasalahan dan penyakit yang berhubungan dengan organ pencernaan, salah satunya adalah konstipasi. Tape ketan hitam mengandung zat dengan kandungan serat yang lebih tinggi dan aktivitas antioksidan lebih baik karena telah mengalami fermentasi. Tape ketan hitam memiliki kandungan antosianin yang tinggi yang berfungsi untuk kesehatan seperti mencegah resiko kanker kolon. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian snack bar tape ketan hitam terhadap frekuensi defekasi pada remaja putri. Penelitian ini menggunakan desain penelitian eksperimental murni. Kelompok intervensi diberikan Snack Bar tape ketan hitam sebanyak 1 potong seberat 30 gram, sedangkan kelompok kontrol diberikan edukasi. Jumlah sampel pada penelitian ini adalah 38 orang. Analisa Bivariabel dilakukan menggunakan Independent T Test dan Wilcoxon Test. Secara statistik tidak terdapat perbedaaan bermakna frekuensi BAB setelah pemberian snack bar tape ketan hitam antara pada kelompok intervensi dan kelompok kontrol dengan nilai p=0,732 (p>0,05). Penelitian ini perlu dilakukan lebih dalam agar efektivitas pemberian snack bar tape ketan hitam terhadap frekuensi defekasi dapat lebih terlihat.
The Candidate Training Impact Towards Participants’ Cognitive and Behavior of Mental Illness Early Detection
Authors: Susanti Susi , Avianti Nani , Muryati Muryati
Published: May 2022

This study is to reveal the impact of the candidate training of mental illness early detection to participants’ cognitive and behaviour towards mental illness detection. It is expected that participants able to recognize the symtomp of mental illness and detect in early stage to tackle it.  The candidate could identify as part of mental health service then report this to the nearest Puskesmas. This would solve some problems of mental health in community in detecting the indication that occurs and influence the community in 10 hamlets which have 24 integrated healthcare centre covered 25.753 population. This big sub-district that lays near education area and having immigrant from other areas has potential to raise the psychosocial problems as mental illness.The research population is 80 of participants or candidates by proportional sampling and use quasi-experimental dengan one group pretest and posttest design. The statistic test used is Wilcoxon Signed Ranks Test to test the candidates’ cognitive and pairs sample t for candidates’ behavior. The result showed that candidates’ cognitive increased significantly after they discussed in small groups with the module of early detection (Pvalue = 0,000<0,05). The behavior has increased significantly as well with the same method (Pvalue = 0,008<0,05).
HUBUNGAN KECEMASAN TERHADAP KELUHAN MENOPAUSE PADA WANITA USIA 45-50 TAHUN DI KECAMATAN TANAH SEREAL KOTA BOGOR
Authors: Agustina Agustina , Nawati Nawati
Published: May 2022

The health problem of women towards elderly is menopause syndrome starting from 40 to 45 years old and it needs attention. It is estimated that one-third of a woman's life span will be in age with a hypoestrogen condition. Women will experience various kinds of disorders both physically and psychologically which negatively impact both in the short and long term.  Factors that can influence complaints during menopause are physiological factors due to decreased ovarian activity, socio-cultural and psychological factors that underlie women's personality.  

This study used a cross sectional approach which aims to learn more about the relationship between anxiety levels with menopausal women's complaints. The research was carried out in the working area of the Tanah Sareal Community Health Center, Central Bogor District, starting from Oktober until November 2020 with a questioner via E-form conducted to 107 respondents. Results: The age of the respondents was dominated by 50-55 years with an elementary and high school education background. In general, respondents are married and some have normal nutritional status and tend to be obese, most of them do not smoke. Bivariate analysis showed that there was  a significant relationship between anxiety and menopause complaints. Multivariate analysis confounder test with regression, the variable anxiety was the most closely related to menopausal complaints with p = 0.023 and an OR value of 5.7. It is recommended that Tanah Sereal Puskesmas carry out health promotion to change women's views about menopause as a physiological thing and pay more attention to psychological aspects in providing health services. The results of this study can be taken into consideration in developing a nursing intervention model in the form of more comprehensive health promotion in preventing and overcoming menopausal complaints by involving family members.
EFKTIVITAS PENDIDIKAN KESEHATAN DENGAN PENDEKATAN MODEL INFORMATION MOTIVATION BEHAVIOR SKILL TERHADAP PENCEGAHAN PERILAKU SEKSUAL BERISIKO REMAJA
Authors: Legiati Titi , Indrayani Diyan
Published: May 2022

ABSTRAK

 

Remaja merupakan masa transisi dari anak-anak menuju dewasa. Pada saat ini usia remaja berpacaran terjadi di usia yang lebih muda, sementara mereka tidak memiliki keterampilan hidup yang memadai. Perilaku seksual berisiko diantara remaja disebabkan karena krisis identitas, kurangnya pengetahuan dan perhatian orang tua, pergaulan yang buruk serta informasi yang salah. Strategi untuk menghindari perilaku seksual berisiko pada remaja adalah dengan memberikan edukasi kesehatan. information, motivation behavior skill model menjelaskan bagaimana melakukan perilaku sehat melalui perbaikan informasi, motivasi dan keterampilan.

Tujuan dari penelitian ini adalah untuk menjelaskan pengaruh pendidikan kesehatan dengan pendekatan information, motivation behavior skill model terhadap pengetahuan, sikap dan keterampilan pencegahan perilaku seksual berisiko. Penelitian menggunakan  quasi experiment dengan pre-post desain. Sampel sejumlah 37 orang remaja dengan usia 15-18 tahun. Data dianalisis menggunakan Paired T-test. Booklet pendidikan kesehatan dengan pendekatan Information, motivation behavior skill model digunakan dalam penelitian ini.

Hasil penelitian didapatkan banwa sebagian besar responden adalah remaja perempuan, sebagian besar responden memilki pacar, terdapat perbedaan pengetahuan, sikap dan keterampilan yang signifikan sebelum dan setelah intervensi. Pendidikan kesehatan dengan pendekatan information, motivation behavior skill model berpengaruh terhadap peningkatan pengetahuan, sikap dan keterampilan terhadap pencegahan perilaku seksual berisiko, sehingga dapat diberikan kepada remaja melalui kegiatan ekstrakulikuler untuk meningkatkan pengetahuan,sikap dan keterampilan mencegah perilaku seksual berisiko
ANALISIS KADAR KALSIUM DAN MAGNESIUM TERHADAP KEJADIAN STUNTING BALITA DI PUSKESMAS TITIPAPAN MEDAN DELI
Authors: Ratnalela Srg Ice , Nasution Sri Bulan , Sofia Endang , Pane Halimah Fitriani
Published: May 2022

Stunting is a growth disorder as an indicator of chronic malnutrition. One of the factors that affect stunting is the low intake of bone-forming nutrients such as calcium and magnesium which is consumed, causing the calcium content in the blood to decrease. The minerals calcium and magnesium work synergistically where magnesium helps accelerate the absorption of calcium. This study aims to analyze the difference between calcium and magnesium in stunted and non-stunted toddlers at the Titi Papan Health Center, Medan Deli District. This research was conducted in August 2020 at the Titi Papan Public Health Center, Medan Deli District, using an analytical observational research design with a cross sectional research design conducted on 35 stunted toddlers and 35 non-stunted toddlers. Sample selection using Simple Random Sampling technique. Data analysis used statistical test with T-Independent test technique. The results showed that there was a significant difference in the average calcium levels between stunted and non-stunted toddlers with a value (p=0.0001), there was no significant difference in the average magnesium levels of stunting and non-stunted toddlers with a value (p=0.176).
PENGARUH FAST FOOD TERHADAP GIZI LEBIH PADA REMAJA DI ERA PANDEMI COVID-19
Authors: Herlina Sara , Qomariah Siti , Sartika Wiwi , Juwita Sellia
Published: May 2022

Masalah gizi ada di tiap negara,  Prevalensi gemuk pada remaja tahun 2010 sebesar 1,4%, tahun 2013 sebesar 5,7% dan mengalami peningkatan pada tahun 2018 sebanyak 10,8%. Prevalensi remaja dengan kategori gemuk pada tahun 2018 sebanyak 9,1%. Salah satu yang mepengaruhi gizi lebih adalah konsumsi fast food. Penelitian ini bertujuan untuk mengetahui pengaruh fast food terhadap gizi lebih pada remaja di era pandemi COVID-19. Jenis penelitian ini adalah kuantitatif dengan  desain penelitian cross sectional. Lokasi penelitian di Kota Pekanbaru dengan jumlah sampel 335 orang. Pengambilan sampel dengan metode simple random  sampling. Pengumpulan data dilakukan dengan wawacara dan observasi. Instrumen yang digunakan untuk mengumpulkan data adalah kuesioner. Analisis data dilakukan secara deskriptif dan analisa bivariat menggunakan uji chi- square. Hasil penelitian univariat sebagian besar responden jarang mengkonsumsi 192 responden (57,3%). Hasil analisa bivariat dengan  uji statistik  uji chi-square diperoleh nilai p = 0,000 (p<0,05) artinya ada pengaruh antara fast food dengan gizi lebih. Kesimpulan hasil penelitian ini adalah pengaruh antara fast food dengan gizi lebih pada remaja di massa pandemi covid-19.
EFEKTIFITAS TERAPI SPA KAKI DALAM MENURUNKAN KELUHAN NEUROPATI DIABETIK PADA PASIEN DIABETES MELLITUS
Authors: Hastuti Mona
Published: May 2022

Indonesia is facing diabetes mellitus disease as a pandemic global, which Indonesia is standing at 6thrank with population of the country has the most diabetes mellitus patients at the age of 20 to 79 in the world and is expected to increase by the time (IDF 2017). Peripheral vascular and sensory to motor neuropathy disease are the highest complications of diseases and frequently found in diabetes mellitus case. Diabetik foot spa is one of the therapies to boost patient’s blood circulation also provide a relax feeling for patient’s feet, therefore this activities aims to observe the effectiveness of diabetik foot spa treatment to the patients of diabetes mellitus to minimize diabetik neuropathic. This study used a quasi-experimental research design with pretest-posttest techniques, took action in two groups, the intervention group and Kontrol group, each group consist of 25 samples in 4 weeks of observation period at “Puskesmas Sunggal”. Found that there was a significant point result on the Paired Samples t-test pretest-posttest test with p value= 0.000 at the 0.05 level for the intervention group in the comparison result before action and after and on the other hand in the Kontrol group was found p value result with 0.587 at the 0.05 level. This study shows that respondents who were given the diabetik foot spa in the intervention group had better feeling and sensation after than before the treatment were given to the patients
HUBUNGAN PENGETAHUAN TENTANG KANKER PAYUDARADENGAN PARTISIPASI WANITA DALAM DETEKSIDINI KANKERPAYUDARA
Authors: Ginting Chrismis Novalinda
Published: May 2022

Breast cancer is a condition in which cells have lost their normal control and mechanisms, resulting in abnormal growth that occurs in breast tissue. How to prevent breast cancer by doing a breast self-examination. Signs and symptoms of breast cancer include a lump in the breast, changes in the breast, nipple discharge, and breast engorgement. The purpose of this study was to determine the relationship between knowledge of breast cancer and women's participation in early detection of breast cancer in the first environment of Tanjung Gusta Village, Medan, which was held on 19-29 June 2019 with a population of 62 people. The sampling technique used a random sampling method. The data collection method in this research is using primary data. The results of this study indicate that the majority of women with sufficient knowledge about breast cancer are as many as 25 people (40.3%) and the minority of women who are knowledgeable enough about 24 people (38.7%), while the mothers who are well informed are 13 people (21.0%). From the results of the study, the number of women who had participated in breast self-examination was as many as 20 (32.3%) and the number of women who had never had their breast check-ups was 41 (67.7%). Based on the results of this study, it was concluded that the knowledge of women about breast cancer was mostly sufficient, while the participation of women in early detection of breast cancer mostly never did breast self-examination.