bluuebunny/crossref_metadata_2025 huggingface dataset:
A Dual Reporter System for Detecting RNA Interactions in Bacterial Cells
Authors: Kuryllo Kacper , Jahanshahi Shahrzad , Zhu Weijia , Brown Eric D. , Li Yingfu
Published: October 2014

Detecting RNA–partner interactions in cells is often difficult due to a lack of suitable tools. Here we describe a dual reporter system capable of detecting intracellular interactions in which one of the partners is an RNA. The system utilizes two fluorescent proteins with similar maturation rates but distinct spectral properties, specifically cyan fluorescent protein (CFP) and yellow fluorescent protein (YFP). By placing the CFP gene upstream and the YFP gene downstream of an RNA gene of interest, the production of YFP becomes sensitive to RNA–partner interaction, whereas the synthesis of CFP is not disturbed. Therefore, the RNA–partner interaction can be simply measured by the change in the ratio of fluorescence of YFP over CFP. The utility of our approach is demonstrated through verification of three known RNA–partner interactions in the model bacterium Escherichia coli. Our two‐reporter strategy should be broadly useful to the study of RNA‐targeted interactions in bacteria.
Methane Catalytic Combustion over Hierarchical Pd@CeO2/Si‐Al2O3: Effect of the Presence of Water
Authors: Monai Matteo , Montini Tiziano , Chen Chen , Fonda Emiliano , Gorte Raymond J. , Fornasiero Paolo
Published: October 2014

The influence of water vapor on methane catalytic combustion was studied over a Pd@CeO2/Si‐Al2O3 catalyst, carefully designed to maximize Pd‐CeO2 interaction and prevent metal sintering and compared to a conventional impregnated catalyst with identical chemical composition. Although the nanostructured Pd@CeO2/Si‐Al2O3 catalyst is thermally stable, the addition of water to the reaction feed leads to a transient deactivation at low temperatures, consistent with the well documented competitive adsorption. In addition to this, the hierarchically structured catalyst exhibits an additional severe deactivation after methane oxidation in the presence of water vapor at 600 °C that can be reversed only by heating the catalyst above 700 °C. The presence of water in the reaction feed deactivates the conventional impregnated catalyst less severely and the activity largely returns upon water removal. Catalytic FTIR and CO‐chemisorption data indicate that this severe deactivation process in the hierarchical catalyst is due to the formation of stable OH groups on the surface of the ceria nanoparticles. These hydroxyl groups are suggested to significantly inhibit the oxygen spillover from the CeO2 nanoparticles to Pd, preventing its efficient re‐oxidation, as observed by operando X‐ray absorption near edge spectroscopy (XANES) experiments. At the same time, their presence can contribute to limit the gas phase accessibility of Pd, as indicated by the decrease of CO chemisorption capability. The presence of hydroxyls plays a minor role on the deactivation of the conventional catalyst at 600 °C.
A Linker‐Mediated Self‐Assembly Method to Couple Isocharged Nanostructures: Layered Double Hydroxide–CdS Nanohybrids with High Activity for Visible‐Light‐Induced H2 Generation
Authors: Lee Jang Mee , Gunjakar Jayavant L. , Ham Yeilin , Kim In Young , Domen Kazunari , Hwang Seong‐Ju
Published: October 2014

The electrostatically derived self‐assembly of cationic Zn‐Cr‐layered double hydroxide (LDH) nanosheets and cationic CdS quantum dots (QDs) with anionic linkers leads to the formation of strongly coupled Zn‐Cr‐LDH–CdS nanohybrids. The hybridization with Zn‐Cr‐LDH leads to significant enhancement of the photocatalytic activity of CdS for visible‐light‐induced H2 generation, a property that is attributed to the depression of electron–hole recombination. In comparison with a direct hybridization method between oppositely charged species, this linker‐mediated method provides greater flexibility in controlling the chemical composition and electronic coupling of the nanohybrids. The present hybridization strategy provides a useful method not only to couple two kinds of isocharged nanostructured materials, but also to explore efficient hybrid‐type photocatalysts.
Lewis and Brønsted Acid Cocatalyzed Reductive Deoxyallenylation of Propargylic Alcohols with 2‐Nitrobenzenesulfonylhydrazide
Authors: Liu Zhaohong , Liao Peiqiu , Bi Xihe
Published: October 2014

Invited for the cover of this issue is the group of Prof. Xihe Bi at Northeast Normal University, China. The cover illustrates the reductive deoxyallenylation of challenging sterically hindered tertiary propargylic alcohols, through the reaction with 2‐nitrobenzenesulfonylhydrazide (NBSH), by the combined use of FeF3 and HOTf catalysts. Read the full text of the article at 10.1002/chem.201404692.
ChemInform Abstract: Crystal Structure and Physical Properties of Ternary Phases Around the Composition Cu5Sn2Se7 with Tetrahedral Coordination of Atoms.
Authors: Fan Jing , Carrillo‐Cabrera Wilder , Antonyshyn Iryna , Prots Yurii , Veremchuk Igor , Schnelle Walter , Drathen Christina , Chen Lidong , Grin Yuri
Published: October 2014

Polycrystalline Cu5Sn2Se7 is prepared from the elements (evacuated quartz ampoule, 1173 K, 12 h).
ChemInform Abstract: Bulk Silicon Crystals with the High Boron Content, Si1—x Bx: Two Semiconductors Form an Unusual Metal.
Authors: Ovsyannikov Sergey V. , Gou Huiyang , Karkin Alexander E. , Shchennikov Vladimir V. , Wirth Richard , Dmitriev Vladimir , Nakajima Yoichi , Dubrovinskaia Natalia , Dubrovinsky Leonid S.
Published: October 2014

Bulk diamond‐structured Si1‐xBx alloys (x ≤ 2.4 at.%) are prepared by high‐temperature/high‐pressure synthesis using Si and β‐Boron crystals (hexagonal BN capsules in multi‐anvil press, 1573—1973 K, 3—20 GPa, 1—2 h).
ChemInform Abstract: Crystal Chemistry and Optical Investigations of the Cu2Zn(Sn,Si)S4 Series for Photovoltaic Applications.
Authors: Hamdi Mohamed , Lafond Alain , Guillot‐Deudon Catherine , Hlel Faouzi , Gargouri Mohamed , Jobic Stephane
Published: October 2014

The series of compounds Cu2ZnSn1‐xSixS4 with 0 ≤ x ≤ 1 is prepared from stoichiometric amounts of the elements (silica tubes, 750—900 °C, 7 d) and characterized by powder and single crystal XRD, and UV/VIS/NIR diffuse reflectance spectroscopy.
ChemInform Abstract: Crystal Structure and Luminescence Properties of a Novel Red‐Emitting Phosphor BaAlBO3F2:Eu3+.
Authors: Chen Wanping , Zhou Ahong , Liu Yan , Dai Xiaoyan , Yang Xin
Published: October 2014

BaAlBO3F2:xEu3+ (0.001 ≤ x ≤ 0.08) phosphors are synthesized by solid state reaction of Al2O3, Eu2O3, H3BO3, BaCO3, and NH4F (air, 850 °C, 5 h).
ChemInform Abstract: Synthesis, Structure and Dielectric Properties of New Ordering Perovskites LnPbMgSbO6 (Ln: La, Pr, Nd).
Authors: Han Lin , Bai Yijia , Liu Xiaojuan , Yao Chuangang , Meng Junling , Liang Qingshuang , Wu Xiaojie , Meng Jian
Published: October 2014

Polycrystalline LnPbMgSbO6 (Ln: La, Pr, Nd) are prepared by a two‐step method.
ChemInform Abstract: A Honeycomb‐Layered Na3Ni2SbO6: A High‐Rate and Cycle‐Stable Cathode for Sodium‐Ion Batteries.
Authors: Yuan Dingding , Liang Xinmiao , Wu Lin , Cao Yuliang , Ai Xinping , Feng Jiwen , Yang Hanxi
Published: October 2014

Na3Ni2SbO6 is prepared by solid state reaction of stoichiometric amounts of Na2CO3, Sb2O3, and NiO (900 °C, 12 h) as a cathode for Na‐ion batteries.
ChemInform Abstract: The Synthesis and Characterization of Four New Uranium(IV) Chlorophosphates: UCl4(POCl3), [U2Cl9][PCl4], UCl3(PO2Cl2), and U2Cl8(POCl3).
Authors: Ward Matthew D. , Chan Ian Y. , Lebegue Sebastien , Ibers James A.
Published: October 2014

Under identical conditions, the solid state reaction of (I) and (II) in the absence of sulfur leads to the formation of (IV) in a first run and (V) in a second run.
ChemInform Abstract: Direct Remote Asymmetric Bisvinylogous 1,4‐Additions of Cyclic 2,5‐Dienones to Nitroalkenes.
Authors: Zhou Zhi , Feng Xin , Yin Xiang , Chen Ying‐Chun
Published: October 2014

Regioselective 1,4‐additions of cyclic 2,5‐dienones to nitroalkenes in the presence of a chiral catalyst give the corresponding 1,4‐adducts with moderate to high enantioselectivities.
ChemInform Abstract: Cyclic Aldimines as Superior Electrophiles for Cu‐Catalyzed Decarboxylative Mannich Reaction of β‐Ketoacids with a Broad Scope and High Enantioselectivity.
Authors: Zhang Heng‐Xia , Nie Jing , Cai Hua , Ma Jun‐An
Published: October 2014

A new catalytic enantioselective decarboxylative Mannich reaction of β‐ketoacids with cyclic and acyclic aldimines is presented.
ChemInform Abstract: Effect of Sodium Acetate in Atom Transfer Radical Addition of Polyhaloalkanes to Olefins.
Authors: Sawama Yoshinari , Nakatani Ryosuke , Imanishi Takahiro , Fujiwara Yuta , Monguchi Yasunari , Sajiki Hironao
Published: October 2014

Polyhaloalkanes undergo radical 1,2‐addition to olefins under thermal reaction conditions in the presence of NaOAc as an additive.
ChemInform Abstract: [4 + 2 + 2] Cycloaddition Catalyzed by a New Cationic Rhodium—Bisphosphine Monooxide Complex.
Authors: Canlas Gino Martin R. , Gilbertson Scott R.
Published: October 2014

A new Rh‐BozPhos complex, based on a phosphine‐phosphine oxide combination, is reported which is competent in catalyzing the [4 + 2 + 2] cycloisomerization of cyclooctatrienes.
ChemInform Abstract: Ambient Intermolecular [2 + 2] Cycloaddition: An Example of Carbophilicity and Oxophilicity Competition in Au/Ag Catalysis.
Authors: Su Yijin , Zhang Yanwei , Akhmedov Novruz G. , Petersen Jeffrey L. , Shi Xiaodong
Published: October 2014

In the presence of silver only trace amounts of the cycloaddition products are obtained, therefore the silver‐free condition is critical for this reaction.
ChemInform Abstract: Unravelling a New Class of Chiral Organocatalyst for Asymmetric Ring‐Opening Reaction of meso Epoxides with Anilines.
Authors: Kumar Manish , Kureshy Rukhsana I. , Saravanan S. , Verma Shailesh , Jakhar Ajay , Khan Noor‐ul H. , Abdi Sayed H. R. , Bajaj Hari C.
Published: October 2014

The chiral sulfinamide based organocatalyst (I) is synthesized and applied to the asymmetric ring‐opening reaction of meso epoxides with anilines.
ChemInform Abstract: Palladium Nanoparticles Supported on Ionic Liquid Modified, Magnetic Nanobeads — Recyclable, High‐Capacity Catalysts for Alkene Hydrogenation.
Authors: Linhardt Roland , Kainz Quirin M. , Grass Robert N. , Stark Wendelin J. , Reiser Oliver
Published: October 2014

Magnetically recoverable hybrid materials consisting of Pd‐nanoparticles supported on magnetic cobalt‐carbon nanobeads functionalized with imidazolium‐based ionic liquid are synthesized and their activity for the catalytic hydrogenation of olefins and nitroarenes is demonstrated.
ChemInform Abstract: Enantioselective Allylic Amination of Trifluoromethyl Group Substituted Racemic and Unsymmetrical 1,3‐Disubstituted Allylic Esters by Palladium Catalysts.
Authors: Kawatsura Motoi , Terasaki Shou , Minakawa Maki , Hirakawa Takuya , Ikeda Kazunori , Itoh Toshiyuki
Published: October 2014

A facile protocol for the regio‐ and enantioselective allylic amination of allylic esters to give the corresponding α‐type allylic amines is presented.
ChemInform Abstract: MCF‐Supported Boronic Acids as Efficient Catalysts for Direct Amide Condensation of Carboxylic Acids and Amines.
Authors: Gu Liuqun , Lim Jaehong , Cheong Jian Liang , Lee Su Seong
Published: October 2014

A new class of catalysts for direct amide condensation is developed by immobilizing boronic acids on mesocellular siliceous foam.
ChemInform Abstract: Catalytic Asymmetric α‐Aldol Reaction of Vinylogous N‐Heterocyclic Carbene Enolates: Formation of Quaternary and Labile Tertiary Stereocenters.
Authors: Dong Xiuqin , Sun Jianwei
Published: October 2014

Vinylogous N‐heterocyclic carbene enolates generated from enals (I) and a chiral oxazine catalyst undergo unexpected α‐aldol reactions with trifluoropyruvate as the carbon electrophile to give enantioenriched α‐fluroalkylated esters (IV).
ChemInform Abstract: Directed ortho Metalation Strategies. Effective Regioselective Routes to 1,2‐, 2,3‐, and 1,2,3‐Substituted Naphthalenes.
Authors: Groom Katherine , Hussain S. M. Shakil , Morin Justin , Nilewski Christian , Rantanen Toni , Snieckus Victor
Published: October 2014

Directed ortho‐metalation of naphthyl‐2‐carbamate followed by reaction with various electrophiles affords di‐ and trisubstituted naphthalenes with high regioselectivity.
ChemInform Abstract: Supported Imidazolylphosphine Catalysts for Highly (E)‐Selective Alkene Isomerization.
Authors: Erdogan Gulin , Grotjahn Douglas B.
Published: October 2014

Highly (E)‐selective isomerization of terminal olefins is achieved by polystyrene‐supported bifunctional catalysts.
ChemInform Abstract: A Practical and Scalable Process to Selectively Monofunctionalize Water‐Soluble α,ω‐Diols.
Authors: Zhang Quanxuan , Ren Hong , Baker Gregory L.
Published: October 2014

Monofunctionalized diols such as (VI) and (XI) are prepared using a simple and inexpensive tetrahydropyrane ether protection/deprotection strategy.
ChemInform Abstract: Pentafluorosulfanyldifluoroacetic Acid: Rebirth of a Promising Building Block.
Authors: Matsnev Andrej V. , Qing Si‐Yan , Stanton Mark A. , Berger Kyle A. , Haufe Guenter , Thrasher Joseph S.
Published: October 2014

Three novel and easily scalable approaches for the synthesis of the title acid (III) are developed.
ChemInform Abstract: Direct Imine Formation by Oxidative Coupling of Alcohols and Amines Using Supported Manganese Oxides under an Air Atmosphere.
Authors: Chen Bo , Li Jun , Dai Wen , Wang Lianyue , Gao Shuang
Published: October 2014

Without additional base and excess of alcohols or amines, diverse types of substituted imines such as (III) and (V) are obtained in good to high yields.
ChemInform Abstract: Tandem N‐Alkylation—Addition Reaction of α‐Aldimino Ester and Application to a New Flow System.
Authors: Sano Takanori , Mizota Isao , Shimizu Makoto
Published: October 2014

In the case of N‐octylation‐addition reaction of compound (I) to (VIII) a higher reaction yield is obtained by using a flow system consisting of two connected micromixers.
ChemInform Abstract: Practical and Scalable Syntheses of Substituted Ketene Dithioacetal Monoxides.
Authors: Murakami Kei , Yorimitsu Hideki , Osuka Atsuhiro
Published: October 2014

Title compounds [(III), (VII), and (XIII)] are synthesized in gram scales following different methods.
ChemInform Abstract: An Environmentally‐Friendly One‐Pot Synthesis of 4‐Sulfonyl Benzoic Acids.
Authors: Frieman Bryan A.
Published: October 2014

SNAr reaction of thiolates with 4‐halobenzoates followed by bleach‐mediated oxidative workup allows the synthesis of the title species on multi‐gram scale.
ChemInform Abstract: A Rh‐Catalyzed Regio‐ and Stereoselective Route to Enamides: Benzamides as Assembling Reagents.
Authors: Lee Dong Jin , Shin Jinhwan , Yoo Eun Jeong
Published: October 2014

A novel method is elaborated for the preparation of substituted enaminones (III) and (VI) by a Rh‐catalyzed reaction of triazoles (I) and (V) with amides (II).
ChemInform Abstract: Modular Synthesis of Ar‐BINMOL‐Phos for Catalytic Asymmetric Alkynylation of Aromatic Aldehydes with Unexpected Reversal of Enantioselectivity.
Authors: Song Tao , Zheng Long‐Sheng , Ye Fei , Deng Wen‐Hui , Wei Yun‐Long , Jiang Ke‐Zhi , Xu Li‐Wen
Published: October 2014

The synthesis of the chiral ligand is described.
ChemInform Abstract: One‐Pot Synthesis of 1‐Amidoalkyl‐2‐naphthols under Solvent‐Free Conditions
Authors: Maleki Behrooz , Taimazi Fereshteh
Published: October 2014

using three‐component reactions catalyzed by N‐bromophthalimide, trichloroisocyanuric acid or NaCl
ChemInform Abstract: Rhodium(III)‐Catalyzed Coupling of N‐Sulfonyl 2‐Aminobenzaldehydes with Oxygenated Allylic Olefins Through C—H Activation.
Authors: Yang Tingting , Zhang Tao , Yang Shangdong , Chen Shanshan , Li Xingwei
Published: October 2014

Diarylketones, e.g. (III), (V) and (VII)/(VIII), are obtained through coupling of title compounds (I) with 7‐oxabenzonorbornadienes.
ChemInform Abstract: Phosphoric Acid Catalyzed Diastereo‐ and Enantioselective Synthesis of Substituted 1,3‐Diaminotetralins.
Authors: Dagousset Guillaume , Erb William , Zhu Jieping , Masson Geraldine
Published: October 2014

1,3‐Diaminotetralins are prepared stereoselectively from benzylic aldehydes and anilines in the presence of chiral phosphoric acid.
ChemInform Abstract: Asymmetric Formal [3 + 2] Cycloaddition Reaction of Succinaldehyde via Diarylprolinol‐Mediated Domino Aldol—Acetalization Reaction for the Construction of Tetrahydrofuran.
Authors: Hayashi Yujiro , Nishino Kentaro , Sato Itaru
Published: October 2014

Transformation of benzaldehyde and aliphatic aldehydes such as 3‐phenylpropanal hardly proceeds.
ChemInform Abstract: Palladium‐Catalyzed Tandem Reaction of 2‐Hydroxyarylacetonitriles with Sodium Sulfinates: One‐Pot Synthesis of 2‐Arylbenzofurans.
Authors: Chen Jiuxi , Li Jianjun , Su Weike
Published: October 2014

The presented approach is suited to be scaled up.
ChemInform Abstract: Synthesis of Spirooxindoles from Carbamoyl Chlorides via Cyclopropyl Methine C(sp3)—H Activation Using Palladium Catalyst.
Authors: Tsukano Chihiro , Okuno Masataka , Takemoto Yoshiji
Published: October 2014

The palladium‐catalyzed cyclization of o‐cycloalkylated carbamoyl chlorides (I) affords desired spirooxindoles (II) in moderate to good yields.
ChemInform Abstract: Indium‐Catalyzed Annulation of Indoles with Ethyl (2‐Ethynylaryl)methyl Carbonates: Synthesis and Photoluminescent Properties of Aryl‐ and Heteroaryl[b]carbazoles.
Authors: Nagase Yuta , Miyamura Takuhiro , Inoue Kensuke , Tsuchimoto Teruhisa
Published: October 2014

Electrophils having an internal alkynyl group fail to undergo an annulation.
ChemInform Abstract: Dearomative Indole [3 + 2] Cycloaddition Reactions.
Authors: Li Hui , Hughes Russell P. , Wu Jimmy
Published: October 2014

The presented diastereoselective cycloaddition of indoles with α‐haloketones provides an easy access to highly functionalized cyclopenta‐ or cyclohexa‐fused indoles.
ChemInform Abstract: Chiral Anion Phase Transfer of Aryldiazonium Cations: An Enantioselective Synthesis of C3‐Diazenated Pyrroloindolines.
Authors: Nelson Hosea M. , Reisberg Solomon H. , Shunatona Hunter P. , Patel Jigar S. , Toste F. Dean
Published: October 2014

The aryldiazonium cations as source of electrophilic nitrogen are used for the first time in an asymmetric reaction.
ChemInform Abstract: An Efficient Synthesis of Bis‐1,3‐(3′‐aryl‐N‐heterocycl‐1′‐yl)arenes as CCC‐NHC Pincer Ligand Precursors.
Authors: Howell Tyler O. , Huckaba Aron J. , Hollis T. Keith
Published: October 2014

CCC‐NHC pincer ligands are prepared from bisimidazoles and bis(aryl)iodonium salts.
ChemInform Abstract: An Efficient and Recyclable Heterogeneous Catalytic System for the Synthesis of 1,2,4‐Triazoles Using Air as the Oxidant.
Authors: Meng Xu , Yu Chaoying , Zhao Peiqing
Published: October 2014

A mixed Cu/Zn‐catalyst supported on Al2O3‐TiO2 is used as catalyst for the cyclocondensation of 2‐aminopyridines or amidine hydrochlorides with nitriles to give the corresponding 1,2,4‐triazoles.
ChemInform Abstract: Silica Supported Lanthanum Triflate Mediated Synthesis of 5‐Substituted 1H‐Tetrazoles.
Authors: Meshram Gangadhar A. , Deshpande Shruti S. , Wagh Pramod A. , Vala Vipul A.
Published: October 2014

Optimized reaction conditions including silica supported lanthanum triflate as the catalyst are developed for the cycloaddition between aromatic nitriles and sodium azide to produce various tetrazoles.
ChemInform Abstract: Iron Corrole‐Catalyzed [4 + 2] Cycloaddition of Dienes and Aldehydes.
Authors: Kuwano Toru , Kurahashi Takuya , Matsubara Seijiro
Published: October 2014

Besides the iron (IV) corrole catalyst FEC, an iron(III) porphyrin complex shows catalytic activity as well.
ChemInform Abstract: Annulation of 2H‐Pyran onto 1‐Oxa‐ or 1‐Azacyclohexane‐2,4‐diones and Their Analogues via Sequential Condensation with α‐Substituted Enals and 6π‐Electrocyclization.
Authors: Hossain Md. Imran , Shaban Elkhabiry , Ikemi Taku , Peng Wei , Kawafuchi Hiroyuki , Inokuchi Tsutomu
Published: October 2014

Dihydropyrano[4,3‐b]pyranone derivatives are prepared via a Knoevenagel condensation followed by a 6π‐electrocyclization.
ChemInform Abstract: Regioselective Nucleophilic Ring‐Opening Reaction of Chiral Epoxyallyl Alcohols: A Ready Access to the Pyran Core of Macrolactin 3.
Authors: Radha Krishna Palakodety , Nomula Rajesh , Rama Krishna Kallaganti V. S.
Published: October 2014

The synthesis of the pyran core (VI) of macrolactin 3 is based on Sharpless epoxidation, Ti(IV)‐promoted nucleophilic regioselective epoxide ring‐opening, and oxa‐Michael addition as the key steps.
ChemInform Abstract: Three‐Step Assembly of 4‐Aminotetrahydropyran‐2‐ones from Isoxazoline‐2‐oxides.
Authors: Naumova A. S. , Mikhaylov A. A. , Khomutova Yu. A. , Novikov R. A. , Arkhipov D. E. , Korlyukov A. A. , Ioffe S. L.
Published: October 2014

In this paper a convenient strategy for the synthesis of the title compounds is suggested.
ChemInform Abstract: 1‐(1‐Alkylsulfonic)‐3‐methylimidazolium Chloride Broensted Acidic Ionic Liquid Catalyzed Skraup Synthesis of Quinolines under Microwave Heating.
Authors: Amarasekara Ananda S. , Hasan Muhammad A.
Published: October 2014

The ionic liquid promoted Skraup synthesis of quinolines involving the in situ formation of acrolein by dehydration of glycerol under microwave conditions.
ChemInform Abstract: Organocatalytic Asymmetric Michael—Michael Cascade for the Construction of Highly Functionalized N‐Fused Piperidinoindoline Derivatives.
Authors: Zhao Yong‐Long , Wang Yao , Cao Jian , Liang Yong‐Min , Xu Peng‐Fei
Published: October 2014

Michael—Michael cascade reaction of indole derivatives with nitroalkenes in the presence of cinchona derived bifunctional thiourea catalyst results in the formation of piperidinoindolines with moderate diastereoselectivities and excellent enantioselectivities.
ChemInform Abstract: A Facile Method for the Synthesis of Steroidal and Nonsteroidal 5‐Methyl Pyrazolo[1,5‐a]pyrimidines.
Authors: Kaishap Partha Pratim , Baruah Swagata , Shekarrao Kommuri , Gogoi Sanjib , Boruah Romesh C.
Published: October 2014

Base‐mediated reaction of α,β‐unsaturated ketones (I) and (VI) with aminopyrazoles gives the title compounds in good yields.
ChemInform Abstract: Ru‐Catalyzed Rearrangement of N‐Methyl Isoxazolidines to N—H 1,3‐Oxazinanes: A Strategy of Self‐Hydride Transferring Cleavage of N—O Bonds.
Authors: Yao Chuan‐Zhi , Xiao Zu‐Feng , Liu Jie , Ning Xiao‐Shan , Kang Yan‐Biao
Published: October 2014

Cis‐1,3‐Oxazinanes are formed in one step from N‐methyl nitrones via isoxazolidines.
ChemInform Abstract: A Trifluoroacetic Acid Catalyzed Domino Reaction as an Approach to Amino Acid Derived 2,3‐Dihydro‐1H‐1,5‐benzodiazepines.
Authors: Bera Saurav , Kandiyal Pancham S. , Ampapathi Ravi S. , Panda Gautam
Published: October 2014

The strategy allows the preparation of a library of benzodiazepines with potential pharmaceutical and biological activity.
ChemInform Abstract: Facile Preparation of 1,5‐Diazacyclooctanes from Unsaturated Imines: Effects of the Hydroxyl Groups on [4 + 4] Dimerization.
Authors: Tanaka Katsunori , Matsumoto Risa , Pradipta Ambara R. , Kitagawa Yasutaka , Okumura Mitsutaka , Manabe Yoshiyuki , Fukase Koichi
Published: October 2014

Imines derived from α,β‐unsaturated aldehydes and chiral β‐aminoalcohols undergo [4 + 4] dimerization which is promoted by the attached OH‐group.
ChemInform Abstract: One‐Pot Synthesis of 2,3‐Benzodiazepines from Arynes and β‐Diketones.
Authors: Okuma Kentaro , Tanabe Yukiko , Itoyama Ryoichi , Nagahora Noriyoshi , Shioji Kosei
Published: October 2014

Compound (VII) represents the benzodiazepine drug Tofisopam.
ChemInform Abstract: Rhodium‐Catalyzed Tandem Cyclization/Si—C Activation Reaction for the Synthesis of Siloles.
Authors: Zhang Qing‐Wei , An Kun , He Wei
Published: October 2014

A highly efficient and practical new synthetic strategy for the synthesis of structurally diverse siloles, including the first examples of benzofuran siloles [(XI) and (XII)], is developed.
ChemInform Abstract: A One‐Pot Allylation—Hydrostannation Sequence with Recycling of the Intermediate Tin Waste.
Authors: Ghosh Banibrata , Amado‐Sierra Maria Del Rosario I. , Holmes Daniel , Maleczka Robert E. Jr.
Published: October 2014

A direct one‐pot alkylation‐hydrostannation sequence of alkynes having a remote aldehyde substituent is detailed.
ChemInform Abstract: New Antiproliferative Tricyclic Sesquiterpenoid from the Leaves of Ocimum sanctum.
Authors: Singh Deepika , Kumar Chaudhuri Prabir , Darokar Mahendra P.
Published: October 2014

The tricyclic sesquiterpenoid (I) shows potent antiproliferative activity against the MCF‐7 cell line.
ChemInform Abstract: Pintoxolanes A—C, Highly Functionalized 3,14‐Oxa‐bridged Cembranoids from the Caribbean Gorgonian Coral Eunicea pinta
Authors: Figueroa Janet , Vera Brunilda , Rodriguez Abimael D.
Published: October 2014

isolation, structure determination and preliminary cytotoxicity data of three new cembrane‐based diterpenes, pintoxolanes A (I), B (IIa) and C (IIb)
ChemInform Abstract: Antiinflammatory Terpenoids from Boswellia ovalifoliolata.
Authors: Chib Renu , Kumar Manjeet , Rizvi Masood , Sharma Simmi , Pandey Anjali , Bani Sarang , Andotra Samar S. , Taneja Subhash C. , Shah Bhahwal A.
Published: October 2014

Ten terpenoids ‐ including one new sesquiterpenoid (I) and two new triterpenoids (II) and (III) ‐ were isolated from the title species.
ChemInform Abstract: Protection‐Free Synthesis of Alkyl Glycosides under Hydrogenolytic Conditions.
Authors: Ishihara Masaki , Takagi Yuka , Li Gefei , Noguchi Masato , Shoda Shin‐ichiro
Published: October 2014

In addition to the glycosylation of (II) and (V) using 4,6‐dibenzyloxy‐1,3,5‐triazin‐2‐yl‐β‐glucoside, the method is successfully applied to the corresponding acid sensitive 4,6‐dibenzyloxy‐1,3,5‐triazin‐2‐yl‐β‐melibioside and β‐maltopentaoside derivatives.
ChemInform Abstract: New Alkaloids from Aconitum vaginatum
Authors: Li Juan , Chang Hang , Zhao Wenyu , Pi Huifang , Ruan Hanli , Zhang Peng
Published: October 2014

isolation and structure elucidation of two new amide alkaloids, vaginatunine A (Ia) and B (Ib), and the new C18‐diterpenoid alkaloid, vaginatunine C (II)
ChemInform Abstract: Two New Alkaloids from the Roots of Aconitum sinomontanum Nakai
Authors: Xu Bin , Xue Jiehua , Tan Junjie , Jiang Shanhao , Guo Fujiang , Li Yiming
Published: October 2014

isolation and structure of ranaconidine (I) and N‐(chloromethyl)taspine (II)
ChemInform Abstract: A New Polyketide from the Mangrove Endophytic Fungus Penicillium sp. sk14JW2P.
Authors: Huang Xi‐Shan , Yang Bin , Sun Xue‐Feng , Xia Guo‐Ping , Liu Ya‐Yue , Ma Lin , She Zhi‐Gang
Published: October 2014

Palitantin (II) and the new analogue, 13‐hydroxypalitantin (I), exhibit acetylcholinesterase (AchE) inhibitory activities.
ChemInform Abstract: Synthetic Studies on Natural Products. Part 74. Stereoselective Total Synthesis of psiAβ — A Sporogenic Psi Factor from Aspergillus nidulans.
Authors: Reddy Parigi Raghavendar , Lingaiah Maram , Das Biswanath
Published: October 2014

The asymmetric total synthesis of psiAβ from pentane‐1,5‐diol is described.
ChemInform Abstract: The Electronic Structure and Geometric Structure of Nanoclusters as Catalytic Active Sites
Authors: Li Hao , Li Linsen , Li Yadong
Published: October 2014

Review: 90 refs.
ChemInform Abstract: Self‐assembled M2L4 Coordination Cages: Synthesis and Potential Applications
Authors: Schmidt Andrea , Casini Angela , Kuehn Fritz E.
Published: October 2014

Review: 95 refs.
ChemInform Abstract: Asymmetric Oxidative Dearomatizations Promoted by Hypervalent Iodine(III) Reagents: An Opportunity for Rational Catalyst Design?
Authors: Harned Andrew M.
Published: October 2014

Review: [57 refs.
ChemInform Abstract: Recent Advances in Michael Addition of H‐Phosphonates
Authors: Rulev A. Yu.
Published: October 2014

Review: 76 refs.
ChemInform Abstract: Progress in Asymmetric Organocatalytic Synthesis of β‐Lactams
Authors: Magriotis Plato A.
Published: October 2014

Review: [61 refs.
ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 1. Uniqueness and Chemotaxonomy
Authors: Ntie‐Kang Fidele , Lifongo Lydia L. , Simoben Conrad V. , Babiaka Smith B. , Sippl Wolfgang , Mbaze Luc Meva'a
Published: October 2014

Review: [focus on alkaloids and flavonoids; 151 refs.
ChemInform Abstract: Pentacoordinated and Hexacoordinated Compounds
Authors: Pajkert Romana , Roeschenthaler Gerd‐Volker
Published: October 2014

Review: synthetic routes to pentacoordinated phosphorus compounds by Wittig reactions s well as preparation of hexacoordinated phosphorus compounds by reaction of alk ylenechlorophosphites with hydroxylated bisazomethines; 17 refs.
ChemInform Abstract: Solid Acids: Green Alternatives for Acid Catalysis
Authors: Gupta Princy , Paul Satya
Published: October 2014

Review: 259 refs.
ChemInform Abstract: Phyllobilins — The Abundant Bilin‐Type Tetrapyrrolic Catabolites of the Green Plant Pigment Chlorophyll
Authors: Kraeutler Bernhard
Published: October 2014

Review: insights into the chlorophyll breakdown; 55 refs.
ChemInform Abstract: Near‐Infrared Light‐Responsive Nanomaterials in Cancer Therapeutics
Authors: Shanmugam Vijayakumar , Selvakumar S. , Yeh Chen‐Sheng
Published: October 2014

Review: 172 refs.
ChemInform Abstract: Will Zeolite‐Based Catalysis be as Relevant in Future Biorefineries as in Crude Oil Refineries?
Authors: Jacobs Pierre A. , Dusselier Michiel , Sels Bert F.
Published: October 2014

Review: [63 refs.
ChemInform Abstract: Catalytic Paradigms: A Riddle and a Puzzle
Authors: van Santen Rutger A.
Published: October 2014

Review: aspects of computational chemistry as well as kinetics and physical state of the reactive catalyst, 22 refs.
ChemInform Abstract: Using Electron Beams to Investigate Catalytic Materials
Authors: Zhang Bingsen , Su Dang Sheng
Published: October 2014

Review: 80 refs.
Understanding the Structural Differences between Spherical and Rod‐Shaped Human Insulin Nanoparticles Produced by Supercritical Fluids Precipitation
Authors: Park Yeonju , Seo Yongil , Chae Boknam , Pyo Dongjin , Chung Hoeil , Hwang Hyonseok , Jung Young Mee
Published: October 2014

In this study, the thermal denaturation mechanism and secondary structures of two types of human insulin nanoparticles produced by a process of solution‐enhanced dispersion by supercritical fluids using dimethyl sulfoxide (DMSO) and ethanol (EtOH) solutions of insulin are investigated using spectroscopic approaches and molecular dynamics calculations. First, the temperature‐dependent IR spectra of spherical and rod‐shaped insulin nanoparticles prepared from DMSO and EtOH solution, respectively, are analyzed using principal component analysis (PCA) and 2D correlation spectroscopy to obtain a deeper understanding of the molecular structures and thermal behavior of the two insulin particle shapes. All‐atom molecular dynamics (AAMD) calculations are performed to investigate the influence of the solvent molecules on the production of the insulin nanoparticles and to elucidate the geometric differences between the two types of nanoparticles. The results of the PCA, the 2D correlation spectroscopic analysis, and the AAMD calculations clearly reveal that the thermal denaturation mechanisms and the degrees of hydrogen bonding in the spherical and rod‐shaped insulin nanoparticles are different. The polarity of the solvent might not alter the structure or function of the insulin produced, but the solvent polarity does influence the synthesis of different shapes of insulin nanoparticles.
Mechanistic Details of the Membrane Perforation and Passive Translocation of TAT Peptides
Authors: Piantavigna Stefania , Abdelhamid Muhammad E. , Zhao Chuan , Qu Xiaohu , McCubbin George A. , Graham Bim , Spiccia Leone , O'Mullane Anthony P. , Martin Lisandra L.
Published: October 2014

The trans‐activator of transcription (TAT) peptide is regarded as the “gold standard” for cell‐penetrating peptides, capable of traversing a mammalian membrane passively into the cytosolic space. This characteristic has been exploited through conjugation of TAT for applications such as drug delivery. However, the process by which TAT achieves membrane penetration remains ambiguous and unresolved. Mechanistic details of TAT peptide action are revealed herein by using three complementary methods: quartz crystal microbalance with dissipation (QCM‐D), scanning electrochemical microscopy (SECM) and atomic force microscopy (AFM). When combined, these three scales of measurement define that the membrane uptake of the TAT peptide is by trans‐membrane insertion using a “worm‐hole” pore that leads to ion permeability across the membrane layer. AFM data provided nanometre‐scale visualisation of TAT punctuation using a mammalian‐mimetic membrane bilayer. The TAT peptide does not show the same specificity towards a bacterial mimetic membrane and QCM‐D and SECM showed that the TAT peptide demonstrates a disruptive action towards these membranes. This investigation supports the energy‐independent uptake of the cationic TAT peptide and provides empirical data that clarify the mechanism by which the TAT peptide achieves its membrane activity. The novel use of these three biophysical techniques provides valuable insight into the mechanism for TAT peptide translocation, which is essential for improvements in the cellular delivery of TAT‐conjugated cargoes including therapeutic agents required to target specific intracellular locations.
Electrospun SnSb Crystalline Nanoparticles inside Porous Carbon Fibers as a High Stability and Rate Capability Anode for Rechargeable Batteries
Authors: Shiva Konda , Rajendra Hongahally B. , Bhattacharyya Aninda J.
Published: October 2014

In an electrochemical alloying reaction, the electroactive particles become mechanically unstable owing to large volume changes occurring as a result of high amounts of lithium intake. This is detrimental for long‐term battery performance. Herein, a novel synthesis approach to minimize such mechanical instabilities in tin particles is presented. An optimal one‐dimensional assembly of crystalline single‐phase tin–antimony (SnSb) alloy nanoparticles inside porous carbon fibers (abbreviated SnSb–C) is synthesized for the first time by using the electrospinning technique (employing non‐oxide precursors) in combination with a sintering protocol. The ability of antimony to alloy independently with lithium is beneficial as it buffers the unfavorable volume changes occurring during successive alloying/dealloying cycles in Sn. The SnSb–C assembly provides nontortuous (tortuosity coefficient, τ=1) fast conducting pathways for both electrons and ions. The presence of carbon in SnSb–C completely nullifies the conventional requirement of other carbon forms during cell electrode assembly. The SnSb–C exhibited remarkably high electrochemical lithium stability and high specific capacities over a wide range of currents (0.2–5 A g−1). In addition to lithium‐ion batteries, it is envisaged that SnSb–C also has potential as a noncarbonaceous anode for other battery chemistries, such as sodium‐ion batteries.
Studies on growth and nucleation kinetics of Piperazinium L‐Tartrate (PPLT) single crystal
Authors: Vijayalakshmi M. , Vizhi R. Ezhil , Babu D. Rajan
Published: October 2014

Single crystal of piperazinium L‐tartrate (PPLT) was grown by slow cooling technique. The crystallanity of grown single crystal was characterized by powder XRD analysis. The solubility, metastable zonewidth and induction period were determined experimentally by adopting gravimetric, polythermal and isothermal method respectively. The experimentally determined interfacial energies agree very well with the theoretically estimated values. The nucleation parameters such as Gibbs free energy change, radius of critical nucleus, nucleation rate and number of molecules present in the critical nuclei of PPLT crystal were evaluated based on the classical theory of nucleation. The nonlinear optical property of the grown crystal was analyzed by using aQ‐switched Nd:YAG laser and the second harmonic generation efficiency of the grown crystal was compared with KDP.
Cerebrospinal fluid cytology of an endolymphatic sac tumor
Authors: Bynum Jennifer P. , Bishop Justin , Ali Syed Z.
Published: October 2014

Endolymphatic sac tumor (ELST) is a rare neoplasm which is seldom evaluated by cytopathology. We report the clinicopathologic course and cytologic cerebrospinal fluid (CSF) findings in a 58‐year‐old patient with brainstem lesions who originally presented with vertigo but progressed to having left 7th, 8th, 9th, and 10th cranial nerve palsies, right‐sided weakness, and occipital headaches. Cytospin of the CSF revealed large epithelioid cells similar to cells seen in a surgical resection of a brain mass three months previously. Review of the surgical specimen revealed a well‐differentiated glandular and papillary neoplasm, most consistent with an endolymphatic sac tumor. Diagn. Cytopathol. 2015;43:339–342. © 2014 Wiley Periodicals, Inc.
Prognostic value of COX‐2, P53, and EZH‐2 evaluated by quantitative image analysis in premalignant and malignant breast lesions
Authors: Nicolopoulou‐Stamati Polyxeni , Tsipis Angelos , Chelidonis George , Patsouris Efstratios , Athanassiadou Pauline , Gonidi Maria , Athanassiadou Anna Maria
Published: October 2014

Background

Cytological differential diagnosis of atypical hyperplasia and well differentiated breast carcinoma may be challenging, because sometimes there is an overlap between the cytomorphological features of these lesions. The aim of the study was to investigate COX‐2, EZH‐2, p53 expression in carcinomas and the gray zone of breast cytology categories of atypical hyperplastic lesions with regard to biological behavior of the tumor.

Methods

FNA speciments from 100 patients with breast hyperplastic lesions and cancer were investigated by immunocytochemistry and a quantitative analysis for COX‐2, p53, and EZH‐2.

Results

Extent of staining for COX‐2 correlated with percentage of positive for EZH‐2 (P < 0.0001) and p53 nuclei (P < 0.001). The intensity of COX‐2 was lower in the carcinoma group (118.57 ± 12.43) than in the hyperplastic (127.16 ± 11.71) group (P = 0.006). On the contrary the mean value of staining extent was greater in the adenocarcinoma cases (15.96 ± 13.03) than in hyperplastic (4.04 ± 1.94) cases (P < 0.0001). The percentage of EZH‐2 and p53 positive cells correlated with the histological type of the lesions (P = 0.001 and P = 0.011, respectively). There was also a statistically significant relation between tumor size and expression of COX‐2 (P = 0.007) and EZH‐2 (P = 0.010).

Conclusion

Our study showed that the expression of COX‐2, EZH‐2, and p53 as determined by immunocytochemistry at quantitative level may be a predictor for distinguishing cytologically atypical hyperplastic from malignant breast lesions and may be regarded as potential prognostic factor in breast cancer patients. Diagn. Cytopathol. 2015;43:294–300. © 2014 Wiley Periodicals, Inc.
Using Multilevel Analysis to Monitor Test Performance Across Administrations
Authors: Wei Youhua , Qu Yanxuan
Published: October 2014

For a testing program with frequent administrations, it is important to understand and monitor the stability and fluctuation of test performance across administrations. Different methods have been proposed for this purpose. This study explored the potential of using multilevel analysis to understand and monitor examinees' test performance across administrations based on their background information. Based on the data of 330,091 examinees' test scores and their background information collected from 254 administrations of an English‐speaking test, the study found: (a) at the individual examinee level, examinees' background had statistically significant relationships with their test performance, and the relationships varied across administrations; however, the prediction of individuals' test scores based on their background variables was not strong, and (b) at the administration level, group composition had strong relationships with administration means; the prediction of administration means based on group composition variables was fairly strong. The results suggest that multilevel analysis has potential application in understanding and monitoring test performance across administrations by identifying statistical relationships between examinees' characteristics and their test performance at both individual and administration levels.
Not all Risk Taking is Born Equal: The Behavioral Agency Model and CEO's Perception of Firm Efficacy
Authors: Martin Geoffrey , Washburn Nathan , Makri Marianna , Gomez‐Mejia Luis R.
Published: October 2014

We examine the relationship between agent (CEO) risk bearing and the quality of executive risk‐taking outcomes, by examining the contingency effect of CEO perceived firm efficacy. In doing so, we extend the behavioral agency model (BAM) beyond predictions of risk magnitude to examining how CEO risk‐taking outcomes differ qualitatively in response to risk bearing. We argue that CEO risk bearing (due to stock options or cash compensation) will positively influence performance outcomes in the presence of higher perceived firm efficacy. However, this positive influence reverses when efficacy is lower. We demonstrate the utility of firm efficacy in exploring the effect of agent risk bearing on performance outcomes and provide the insight that the CEO pay‐performance relationship is influenced by the CEO’s perception of firm efficacy. © 2014 Wiley Periodicals, Inc.
Tensions and Challenges in the Management of Diversity and Inclusion in IT Services Multinationals in India
Authors: Donnelly Rory
Published: October 2014

Information technology (IT) services multinationals in India provide rich environments for the analysis of emerging patterns of diversity and inclusion management. Growing interest in this field of management has been accentuated by claims tabled by the business case and resource‐based rationales. However, challenges and tensions potentially undermine not only the viability of these assertions, but also the impact of diversity and inclusion interventions themselves. This article investigates the tensions and challenges faced by a sample of firms in India in relation to age, gender, and intra‐ and international diversity. The findings shed light on the implications of these tensions for HR management in these organizations, which need to be addressed if the claims put forward by the business‐ and resource‐based perspectives are to be realized and the management of diversity and inclusion is to be successfully aligned with business and HR strategies. © 2014 Wiley Periodicals, Inc.
Chromosome instability in diffuse large B cell lymphomas is suppressed by activation of the noncanonical NF‐κB pathway
Authors: Ramachandiran Sampath , Adon Arsene , Guo Xiangxue , Wang Yi , Wang Huichen , Chen Zhengjia , Kowalski Jeanne , Sunay Ustun R. , Young Andrew N. , Brown Theresa , Mar Jessica C. , Du Yuhong , Fu Haian , Mann Karen P. , Natkunam Yasodha , Boise Lawrence H. , Saavedra Harold I. , Lossos Izidore S. , Bernal‐Mizrachi Leon
Published: October 2014

Diffuse large B cell lymphoma (DLBCL) is the most common form of lymphoma in the United States. DLBCL comprises biologically distinct subtypes including germinal center‐like (GCB) and activated‐B‐cell‐like DLBCL (ABC). The most aggressive type, ABC‐DLBCL, displays dysregulation of both canonical and noncanonical NF‐κB pathway as well as genomic instability. Although, much is known about the tumorigenic roles of the canonical NF‐kB pathway, the precise role of the noncanonical NF‐kB pathway remains unknown. Here we show that activation of the noncanonical NF‐κB pathway regulates chromosome stability, DNA damage response and centrosome duplication in DLBCL. Analysis of 92 DLBCL samples revealed that activation of the noncanonical NF‐κB pathway is associated with low levels of DNA damage and centrosome amplification. Inhibiting the noncanonical pathway in lymphoma cells uncovered baseline DNA damage and prevented doxorubicin‐induced DNA damage repair. In addition, it triggered centrosome amplification and chromosome instability, indicated by anaphase bridges, multipolar spindles and chromosome missegregation. We determined that the noncanonical NF‐κB pathway execute these functions through the regulation of GADD45α and REDD1 in a p53‐independent manner, while it collaborates with p53 to regulate cyclin G2 expression. Furthermore, this pathway regulates GADD45α, REDD1 and cyclin G2 through direct binding of NF‐κB sites to their promoter region. Overall, these results indicate that the noncanonical NF‐κB pathway plays a central role in maintaining genome integrity in DLBCL. Our data suggests that inhibition of the noncanonical NF‐kB pathway should be considered as an important component in DLBCL therapeutic approach.
Heterochromatin structure: Lessons from the budding yeast
Authors: Bi Xin
Published: October 2014

The eukaryotic genome can be roughly divided into euchromatin and heterochromatin domains that are structurally and functionally distinct. Heterochromatin is characterized by its high compactness and its inhibitory effect on DNA transactions such as gene expression. Formation of heterochromatin involves special histone modifications and the recruitment and spread of silencing complexes and causes changes in the primary and higher order structures of chromatin. The past two decades have seen dramatic advances in dissecting the molecular aspects of heterochromatin because of the identification of the histone code for heterochromatin as well as its writers and erasers (histone‐modifying enzymes) and readers (silencing factors recognizing histone modifications). How heterochromatic histone modifications and silencing factors contribute to the special primary and higher order structures of heterochromatin has begun to be understood. The budding yeast Saccharomyces cerevisiae has long been used as a model organism for heterochromatin studies. Results from these studies have contributed significantly to the elucidation of the general principles governing the formation, maintenance, and function of heterochromatin. This review is focused on investigations into the structural aspects of heterochromatin in S. cerevisiae. Current understanding of other aspects of heterochromatin including how it promotes gene silencing and its epigenetic inheritance is briefly summarized. © 2014 IUBMB Life, 66(10):657–666, 2014