bluuebunny/crossref_metadata_2025 huggingface dataset:
Complex Dynamics Analysis and Chaos Control of a Fractional-Order Three-Population Food Chain Model
Authors: Cui Zhuang , Zhou Yan , Li Ruimei
Published: July 2023

The present study investigates the stability analysis and chaos control of a fractional-order three-population food chain model. Previous research has indicated that the predation relationship within a long-established predator–prey system can be influenced by factors such as the prey’s fear of the predator and its carry-over effects. This study examines the state evolution of fractional-order systems and compares their dynamic behavior with integer-order systems. By utilizing the Routh–Hurwitz condition and the stability theory of fractional differential equations, this paper establishes the local stability conditions of the model through the application of the Jacobi matrix and eigenvalue method. Furthermore, the conditions for the Hopf bifurcation generation are determined. Subsequently, chaos control techniques based on the Lyapunov stability theory are employed to stabilize the unstable trajectory at the equilibrium point. The theoretical findings are validated through numerical simulations. These results enhance our understanding of the stability properties and chaos control mechanisms in fractional-order three-population food chain models.
The Hölder Regularity for Abstract Fractional Differential Equation with Applications to Rayleigh–Stokes Problems
Authors: He Jiawei , Wu Guangmeng
Published: July 2023

In this paper, we studied the Hölder regularities of solutions to an abstract fractional differential equation, which is regarded as an abstract version of fractional Rayleigh–Stokes problems, rising up to describing a non-Newtonian fluid with a Riemann–Liouville fractional derivative. The purpose of this article was to establish the Hölder regularities of mild solutions, classical solutions, and strict solutions. We introduced an interpolation space in terms of an analytic resolvent to lower the spatial regularity of initial value data. By virtue of the properties of analytic resolvent and the interpolation space, the Hölder regularities were obtained. As applications, the main conclusions were applied to the regularities of fractional Rayleigh–Stokes problems.
Coupled Fixed Point and Hybrid Generalized Integral Transform Approach to Analyze Fractal Fractional Nonlinear Coupled Burgers Equation
Authors: Bouzgarrou Souhail Mohammed , Znaidia Sami , Noor Adeeb , Ahmad Shabir , Eldin Sayed M.
Published: July 2023

In this manuscript, the nonlinear Burgers equations are studied via a fractal fractional (FF) Caputo operator. The results of coupled fixed point theorems in cone metric space are used to discuss the uniqueness of solution to the proposed coupled equations. The solution of the proposed equation is computed via Natural transform associated with the Adomian decomposition method (NADM). The acquired results are graphically presented for some values of fractional order and fractal dimensions. The accuracy and consistency of the applied method is verified through error analysis.
The Effect of Temperature on the Mechanical Properties of Alginate Gels in Water/Alcohol Solutions
Authors: Malektaj Haniyeh , Drozdov Aleksey D. , deClaville Christiansen Jesper
Published: July 2023

Alginate organohydrogels prepared in water/alcohol mixtures play an important role in electronic and superconductor applications in low-temperature environments. The study deals with the preparation of Ca-alginate organohydrogels and the analysis of their equilibrium swelling and mechanical properties at sub-zero temperatures. It is shown that the equilibrium degree of swelling at room temperature is noticeably affected by the concentration of co-solvents (methanol, ethanol, and 2-propanol) in the mixtures and the number of carbon atoms in the co-solvent molecules. Mechanical properties are studied in small-amplitude oscillatory tests. The data are fitted with a model that involves three material parameters. The influence of temperature is investigated in temperature-sweep oscillatory tests under a cooling-heating program, where a noticeable difference is observed between the storage and loss moduli under cooling and heating (the hysteresis curves). The hysteresis areas are affected by the cooling/heating rate and the number of carbon atoms in the co-solvents.
Effects of Forest Fragmentation on Connectivity and Genetic Diversity in an Endemic and an Invasive Rodent in Northwestern Madagascar
Authors: Ramsay Malcolm S. , Sgarlata Gabriele M. , Barratt Christopher D. , Salmona Jordi , Andriatsitohaina Bertrand , Kiene Frederik , Manzi Sophie , Ramilison Miarisoa L. , Rakotondravony Romule , Chikhi Lounès , Lehman Shawn M. , Radespiel Ute
Published: July 2023

Habitat loss and fragmentation are of concern to conservation biologists worldwide. However, not all organisms are affected equally by these processes; thus, it is important to study the effects of living in fragmented habitats on species that differ in lifestyle and habitat requirements. In this study, we examined the dispersal and connectivity patterns of rodents, one endemic (Eliurus myoxinus) and one invasive (Rattus rattus), in two landscapes containing forest fragments and adjacent continuous forest patches in northwestern Madagascar. We generated genetic (RADseq) data for 66 E. myoxinus and 81 R. rattus individuals to evaluate differences in genetic diversity as well as inbreeding and connectivity in two landscapes. We found higher levels of inbreeding and lower levels of genetic diversity in E. myoxinus compared with R. rattus. We observed related dyads both within and between habitat patches and positive spatial autocorrelation at lower distance classes for both species, with a stronger pattern of spatial autocorrelation in R. rattus. Across each site, we identified contrasting migration rates for each species, but these did not correspond to habitat–matrix dichotomies. The relatively low genetic diversity in the endemic E. myoxinus suggests ecological constraints that require further investigation.
The Prevalence and Associated Factors of Academic Stress among Medical Students of King Khalid University: An Analytical Cross-Sectional Study
Authors: Al-Shahrani Maram M. , Alasmri Bushra S. , Al-Shahrani Reham M. , Al-Moalwi Najwa M. , Al Qahtani Amar A. , Siddiqui Aesha F.
Published: July 2023

Medical students are the category of academic population with the highest levels of stress. This study aimed to assess the prevalence of academic stress among medical students in Saudi Arabia and to identify its associated factors. This cross-sectional study was conducted at the College of Medicine at King Khalid University, Abha. The Medical Student Stressor Questionnaire (MSSQ) was used to evaluate the stress caused by different factors. A total of 422 medical students participated in this study. Among the participants, 115 (27.3%) were male and 307 (72.7%) were female. The highest percentage of students were perceiving moderate to severe stress due to academic-related stressors (97.1%), followed by teaching- and learning-related stressors (93.9%) and group activities-related stressors (88.3%). The lowest domain in which students perceived moderate to severe stress was drive and desire-related stressors (65.8%). The mean percentage of students who perceived moderate-to-severe stress in all domains of stressors was 85.5%. We can conclude that medical students have a high degree of stress, and we emphasize the importance of implementing stress management programs to teach students how to handle stress in order to avoid negative effects on their health and academic performance.
Factors Influencing the Effectiveness of E-Learning in Healthcare: A Fuzzy ANP Study
Authors: Mahdavi Ardestani Seyed Faraz , Adibi Sasan , Golshan Arman , Sadeghian Paria
Published: July 2023

E-learning has transformed the healthcare education system by providing healthcare professionals with training and development opportunities, regardless of their location. However, healthcare professionals in remote or rural areas face challenges such as limited access to educational resources, lack of reliable internet connectivity, geographical isolation, and limited availability of specialized training programs and instructors. These challenges hinder their access to e-learning opportunities and impede their professional development. To address this issue, a study was conducted to identify the factors that influence the effectiveness of e-learning in healthcare. A literature review was conducted, and two questionnaires were distributed to e-learning experts to assess primary variables and identify the most significant factor. The Fuzzy Analytic Network Process (Fuzzy ANP) was used to identify the importance of selected factors. The study found that success, satisfaction, availability, effectiveness, readability, and engagement are the main components ranked in order of importance. Success was identified as the most significant factor. The study results highlight the benefits of e-learning in healthcare, including increased accessibility, interactivity, flexibility, knowledge management, and cost efficiency. E-learning offers a solution to the challenges of professional development faced by healthcare professionals in remote or rural areas. The study provides insights into the factors that influence the effectiveness of e-learning in healthcare and can guide the development of future e-learning programs.
Healthy Lifestyle Score and Glycemic Control in Type 2 Diabetes Mellitus Patients: A City-Wide Survey in China
Authors: Che Mengmeng , Zhou Qin , Lin Weiquan , Yang Yunou , Sun Minying , Liu Xiangyi , Liu Hui , Zhang Caixia
Published: July 2023

Background: Few studies have investigated the combined impact of healthy lifestyle factors on glycemic control. Our study aimed to examine the associations of a healthy lifestyle score (HLS) with glycemic control and to explore the interactive effects of lifestyle factors among patients with type 2 diabetes mellitus (T2DM) in China. Methods: This cross-sectional study was conducted among T2DM patients based on the health management of residents from Guangzhou, China. Good glycemic control was defined as fasting plasma glucose < 7.0 mmol/L. HbA1c < 7.0% was also defined as good glycemic control in sensitivity analysis. The HLS was defined as including physical activity, waist circumference, body mass index, dietary habit, smoking, and alcohol consumption. Logistic regression models were used to examine the associations and interactions between the lifestyle factors and glycemic control. Results: Compared with participants with an HLS ≤ 2, the odds ratios (95% confidence intervals) for an HLS of 3, 4, 5, and 6 were 0.82 (0.77–0.87), 0.74 (0.70–0.79), 0.61 (0.57–0.65), and 0.56 (0.53–0.60), respectively. Significant interactions of healthy lifestyle factors in relation to glycemic control were shown (Pinteraction < 0.05). Conclusions: A healthier lifestyle was significantly associated with good glycemic control in patients with T2DM, and combined healthy lifestyle factors had a better effect than considering them individually.
Design and Content Validation using Expert Opinions of an Instrument Assessing the Lifestyle of Adults: The ‘PONTE A 100’ Questionnaire
Authors: Pérez-Rivas Francisco Javier , Jiménez-González Jennifer , Bayón Cabeza Marianela , Belmonte Cortés Susana , de Diego Díaz-Plaza Marta , Domínguez-Bidagor Julia , García-García David , Gómez Puente Juana , Gómez-Gascón Tomás
Published: July 2023

Lifestyle, a major determinant of health status, comprises a number of habits and behaviours that form a part of daily life. People with healthy lifestyles have a better quality of life, suffer less disease, and have a longer life expectancy. This work reports the design and content validation of a questionnaire—the ‘PONTE A 100’ questionnaire—assessing the lifestyle of adults. This collects information across five dimensions—‘Eating Habits’, ‘Physical Activity’, ‘Smoking and use of Alcohol and other Drugs’, ‘Emotional Wellbeing’, and ‘Safety and Non-intentional Injuries’—via the answering of a total 33 items. Psychometric validation of the instrument’s content was obtained via expert opinions. This was performed by two rounds of assessment and involved 34 experts representing different health science disciplines (mean experience, 27.4 ± 9.4 years). At the end of each round, adjustments were made according to their recommendations. Agreement between the experts was examined using the Aiken V test. A final V value of 0.95 (95% CI, 0.90–1.00) was obtained for the questionnaire as a whole, highlighting the validity of its content. The questionnaire would therefore appear to be an appropriate instrument for assessing the lifestyle of adults.
Comparison of Bone Quality in Middle Ages and Late Modern Period Human Skeletons from Latvia
Authors: Šerstņova Ksenija , Edelmers Edgars , Zolovs Maksims , Pilmane Māra
Published: July 2023

The analysis of bone microstructure and histological examination currently provides valuable insights into various facets of bone biology, ancient human existence, and bone-related diseases. This study aims to scrutinize the microstructure of historic Latvian bones, with three bone element groups selected (humerus, radius, and ulna) from a skeletal collection spanning from the Middle Ages to the Late Modern Period, procured through an archaeological excavation at St. George’s Church in Riga. To evaluate the changes in bone samples over time, two methods are utilized: (i) micro-computed tomography, used for measuring and calculating bone volume/trabecular volume (BV/TV), cortical bone and trabecular thickness, and trabecular pore diameter; (ii) immunohistochemistry (IHC) is employed to detect the presence of Runx2, OPG, OC, MMP2, TIMP2, BFGF, IL-1, IL-10, OPN, defensin-2, BMP 2/4, TGFβ factor in bone cells—specifically osteocytes. Archaeological human bone remains from the Middle Ages period in Latvia display a decline in the average bone volume to trabecular volume ratio when compared with the Late Modern Period, indicating a potential reduction in bone quality in the skeletons, potentially associated with a lower living standard during the earlier era. Comparing factors between the periods reveals a higher value of TIMP2 (p = 0.047) in samples from the Late Modern Period group, while IL-1 is higher (p = 0.036) in the Middle Ages group, which may suggest the presence of disease and diminished bone quality in the skeletons from the Middle Ages.
Effects of Extreme Root Restriction on the Nutritional and Flavor Quality, and Sucrose Metabolism of Tomato (Solanum lycopersicum L.)
Authors: Liu Danxia , Chen Jinxiang , Hao Yanwei , Yang Xiaolong , Chen Riyuan , Zhang Yiting
Published: July 2023

Root restriction is suitable for horticultural soilless cultivation characterized by high efficiency and quality in the case of high density and low node order pinching. However, little research is available on the mechanism of root restriction improving the flavor and nutritional quality of tomatoes. We investigated the effects of Extreme Root Restriction (ERR, 750 mL/plant) on the content of metabolites, activity of enzymes, and gene expression level involving sucrose metabolism in different clusters of two tomato types. The fruit diameter and single fruit weight of common tomato at CIII were reduced by 5.6% and 14% under ERR, as a result, the fruit uniformity throughout the whole plant was improved. The ERR enhanced the accumulation of metabolites in tomato fruits, such as soluble sugars, amino acids, vitamin C, lycopene, and polyphenol, which was caused by ‘concentration effect’ that occurred with a reduction of fruit size. The activities of enzymes (SS, SPS, NI, AI) at CIII and CIV of cherry tomatoes increased by 3–4 folds under ERR. ERR enhanced accumulation of sucrose, glucose, and fructose in tomato fruits not only by modulating activities of metabolizing enzymes but also by inducing the expression of sucrose metabolism genes, including sucrose synthase genes (SS1, SS3–6) in common tomato, fructokinase genes (FKs), hexokinase genes (HKs), and sucrose phosphate synthase genes (SPSs), in cherry tomato. The above results are expected to provide a theoretical basis for root restriction cultivation techniques and practical guidance for high-quality tomato production in industrialized cultivation.
The Relationship between Different Fruit Load Treatments and Fruit Quality in Peaches
Authors: Wang Xiaojun , Yu Mingliang , Guo Shaolei , Ma Ruijuan , Zhang Binbin
Published: July 2023

The effects of different fruit load treatments during peach growth and development on the internal and external quality of peach fruit were studied. At 47 days after full bloom, the plant materials were divided into four treatments: about 100%, 75%, 50% and 25% of fruit were retained. The results showed that as the fruit load was reduced during fruit growth and development, the fruit weight, size, soluble solid contents (SSC), total sugar content, sugar/acid ratio and color quality increased, while the flesh firmness, index of absorbance difference (IAD) and total acid content decreased. Compared with the control treatment in which the fruit were not thinned, the weight of individual mature fruit increased by 24.52%, 39.73% and 51.68% under three fruit thinning treatments (in which about 75%, 50% and 25% of the fruit were left on the tree). SSC increased by 30.78%, 37.63% and 49.69%; total sugar content increased by 13.58%, 22.33% and 31.42%; and the sugar-acid ratio increased by 13.25%, 13.59% and 19.47%, respectively, under the three conditions. In addition, the longitudinal, transverse and lateral diameters of fruit increased to varying degrees when the fruit load was reduced. Furthermore, the fruit firmness and IAD value of fruit skins decreased, and fruit ripening was advanced when the fruit load was reduced. The results showed that fruit quality and flavor were improved significantly by fruit thinning.
The Role of miRNAs in the Development, Proliferation, and Progression of Endometrial Cancer
Authors: Bogaczyk Anna , Zawlik Izabela , Zuzak Tomasz , Kluz Marta , Potocka Natalia , Kluz Tomasz
Published: July 2023

Endometrial cancer is one of the most common cancers in developing and developed countries. Although the detection of this cancer is high at the early stages, there is still a lack of markers to monitor the disease, its recurrence, and metastasis. MiRNAs are in charge of the post-transcriptional regulation of genes responsible for the most important biological processes, which is why they are increasingly used as biomarkers in many types of cancer. Many studies have demonstrated the influence of miRNAs on the processes related to carcinogenesis. The characteristics of miRNA expression profiles in endometrial cancer will allow their use as diagnostic and prognostic biomarkers. This paper focuses on the discussion of selected miRNAs based on the literature and their role in the development of endometrial cancer.
Regulation of mTOR Signaling: Emerging Role of Cyclic Nucleotide-Dependent Protein Kinases and Implications for Cardiometabolic Disease
Authors: Shi Fubiao , Collins Sheila
Published: July 2023

The mechanistic target of rapamycin (mTOR) kinase is a central regulator of cell growth and metabolism. It is the catalytic subunit of two distinct large protein complexes, mTOR complex 1 (mTORC1) and mTORC2. mTOR activity is subjected to tight regulation in response to external nutrition and growth factor stimulation. As an important mechanism of signaling transduction, the ‘second messenger’ cyclic nucleotides including cAMP and cGMP and their associated cyclic nucleotide-dependent kinases, including protein kinase A (PKA) and protein kinase G (PKG), play essential roles in mediating the intracellular action of a variety of hormones and neurotransmitters. They have also emerged as important regulators of mTOR signaling in various physiological and disease conditions. However, the mechanism by which cAMP and cGMP regulate mTOR activity is not completely understood. In this review, we will summarize the earlier work establishing the ability of cAMP to dampen mTORC1 activation in response to insulin and growth factors and then discuss our recent findings demonstrating the regulation of mTOR signaling by the PKA- and PKG-dependent signaling pathways. This signaling framework represents a new non-canonical regulation of mTOR activity that is independent of AKT and could be a novel mechanism underpinning the action of a variety of G protein-coupled receptors that are linked to the mTOR signaling network. We will further review the implications of these signaling events in the context of cardiometabolic disease, such as obesity, non-alcoholic fatty liver disease, and cardiac remodeling. The metabolic and cardiac phenotypes of mouse models with targeted deletion of Raptor and Rictor, the two essential components for mTORC1 and mTORC2, will be summarized and discussed.
Preparation and Characterisation of Acid–Base-Change-Sensitive Binary Biopolymer Films with Olive Oil and Ozonated Olive Oil Nano/Microcapsules and Added Hibiscus Extract
Authors: Janik Magdalena , Khachatryan Karen , Khachatryan Gohar , Krystyjan Magdalena , Żarska Sandra , Ciesielski Wojciech
Published: July 2023

The purpose of this study was to develop and characterise bionanocomposites based on chitosan (CHIT) and alginate (ALG) in two series, which were subsequently functionalised with emulsions based on a combination of water, oil, ozonated oil and hibiscus flower extracts. The structure and morphology of the materials produced were characterised by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and ultraviolet and visible light (UV-Vis) absorption spectroscopy, along with a surface colour analysis and the determination of the mechanical and thermal properties of the resulting composites. Functionalisation did affect the analysed composite parameters. The FTIR spectra indicated that the polysaccharide matrix components were compatible. The SEM images also confirmed the presence of nano/microcapsules in the polysaccharide matrix. The obtained results indicate that the order of adding polysaccharides has a significant impact on the encapsulation capacity. The encapsulation resulted in the improved thermal stability of the composites. The emissions analysis showed that the composites containing nano/microcapsules are characterised by a higher emission intensity and are sensitive to acid or base changes. Significant differences in emission intensity were observed even at low concentrations of acids and bases. A drop in the mechanical properties was observed following functionalisation. The results of this study suggest that these bionanocomposites can be used as active and/or smart packaging materials.
Intratumor Heterogeneity and Treatment Resistance of Solid Tumors with a Focus on Polyploid/Senescent Giant Cancer Cells (PGCCs)
Authors: Mirzayans Razmik , Murray David
Published: July 2023

Single cell biology has revealed that solid tumors and tumor-derived cell lines typically contain subpopulations of cancer cells that are readily distinguishable from the bulk of cancer cells by virtue of their enormous size. Such cells with a highly enlarged nucleus, multiple nuclei, and/or multiple micronuclei are often referred to as polyploid giant cancer cells (PGCCs), and may exhibit features of senescence. PGCCs may enter a dormant phase (active sleep) after they are formed, but a subset remain viable, secrete growth promoting factors, and can give rise to therapy resistant and tumor repopulating progeny. Here we will briefly discuss the prevalence and prognostic value of PGCCs across different cancer types, the current understanding of the mechanisms of their formation and fate, and possible reasons why these tumor repopulating “monsters” continue to be ignored in most cancer therapy-related preclinical studies. In addition to PGCCs, other subpopulations of cancer cells within a solid tumor (such as oncogenic caspase 3-activated cancer cells and drug-tolerant persister cancer cells) can also contribute to therapy resistance and pose major challenges to the delivery of cancer therapy.
Communicating a Positive Result at Newborn Screening and Parental Distress
Authors: Lastrucci Elisa , Daniotti Marta , Procopio Elena , Scaturro Giusi , Tubili Flavia , Martin Rosanna , la Marca Giancarlo
Published: July 2023

The assumption of this study is strictly connected to the need to focus and to know more about the impact on the psychological state of the parents whose newborn babies get a positive result at Expanded Newborn Screening (ENS). As clinical experience shows us, this aspect seems to have a potentially lasting resonance on the way the disease will be managed and handled in the family, leading to potential negative effects and repercussions on the child’s wellbeing and on the quality of life within the family. On the basis of this and on the evidence emerging from a review of the literature, this study aims to investigate and objectify possible distress indicators elicited at the moment of the communication of a positive result at ENS. Questionnaires containing the Beck Depression Inventory-II, the State-Trait Anxiety Inventory-Y, and the Short Form 36 Health Survey tests were administered to the parents of 87 newborns who received positive results at ENS. The parents of 32 babies expressed the presence of discomfort potentially related to the communication of a positive result at ENS.
Development of a Model for Quantitative Assessment of Newborn Screening in Japan Using the Analytic Hierarchy Process
Authors: Konomura Keiko , Hoshino Eri , Sakai Kotomi , Fukuda Takashi , Tajima Go
Published: July 2023

Whether or not conditions should be included in publicly funded newborn screening (NBS) programs should be discussed according to objective and transparent criteria. Certain criteria have been developed for the introduction of NBS programs in the context of individual countries; however, there are no standard selection criteria for NBS programs in Japan. This study aimed to develop a quantitative scoring model to assess newborn screening that incorporates the views of a variety of stakeholders in Japan. The five recommended eligibility criteria for NBS were stratified based on previous studies and expert opinions, using the analytic hierarchy process. We conducted a cross-sectional, web-based questionnaire targeting a wide range of people involved in NBS to investigate pairwise comparisons of the evaluation items between February and April of 2022. There were 143 respondents. Most of our respondents (44.1%) were physicians. Fifty-eight respondents (40.6%) had been engaged in NBS-related research or work for more than 10 years. The distribution of allocation points was the highest for ‘intervention’, ‘screening test’, ‘follow-up setting’, ’economic evaluation’, and ’disease/condition’, in that order. The algorithm in this study will guide decision makers in collecting and evaluating objective data, thus enabling transparent discussions to occur.
Analyzing Social Media Data Using Sentiment Mining and Bigram Analysis for the Recommendation of YouTube Videos
Authors: McGarry Ken
Published: July 2023

In this work we combine sentiment analysis with graph theory to analyze user posts, likes/dislikes on a variety of social media to provide recommendations for YouTube videos. We focus on the topic of climate change/global warming, which has caused much alarm and controversy over recent years. Our intention is to recommend informative YouTube videos to those seeking a balanced viewpoint of this area and the key arguments/issues. To this end we analyze Twitter data; Reddit comments and posts; user comments, view statistics and likes/dislikes of YouTube videos. The combination of sentiment analysis with raw statistics and linking users with their posts gives deeper insights into their needs and quest for quality information. Sentiment analysis provides the insights into user likes and dislikes, graph theory provides the linkage patterns and relationships between users, posts, and sentiment.
Breast Cancer Detection in Mammography Images: A CNN-Based Approach with Feature Selection
Authors: Jafari Zahra , Karami Ebrahim
Published: July 2023

The prompt and accurate diagnosis of breast lesions, including the distinction between cancer, non-cancer, and suspicious cancer, plays a crucial role in the prognosis of breast cancer. In this paper, we introduce a novel method based on feature extraction and reduction for the detection of breast cancer in mammography images. First, we extract features from multiple pre-trained convolutional neural network (CNN) models, and then concatenate them. The most informative features are selected based on their mutual information with the target variable. Subsequently, the selected features can be classified using a machine learning algorithm. We evaluate our approach using four different machine learning algorithms: neural network (NN), k-nearest neighbor (kNN), random forest (RF), and support vector machine (SVM). Our results demonstrate that the NN-based classifier achieves an impressive accuracy of 92% on the RSNA dataset. This dataset is newly introduced and includes two views as well as additional features like age, which contributed to the improved performance. We compare our proposed algorithm with state-of-the-art methods and demonstrate its superiority, particularly in terms of accuracy and sensitivity. For the MIAS dataset, we achieve an accuracy as high as 94.5%, and for the DDSM dataset, an accuracy of 96% is attained. These results highlight the effectiveness of our method in accurately diagnosing breast lesions and surpassing existing approaches.
Biologically Plausible Boltzmann Machine
Authors: Berrones-Santos Arturo , Bagnoli Franco
Published: July 2023

The dichotomy in power consumption between digital and biological information processing systems is an intriguing open question related at its core with the necessity for a more thorough understanding of the thermodynamics of the logic of computing. To contribute in this regard, we put forward a model that implements the Boltzmann machine (BM) approach to computation through an electric substrate under thermal fluctuations and dissipation. The resulting network has precisely defined statistical properties, which are consistent with the data that are accessible to the BM. It is shown that by the proposed model, it is possible to design neural-inspired logic gates capable of universal Turing computation under similar thermal conditions to those found in biological neural networks and with information processing and storage electric potentials at comparable scales.
A Balancing Act: Navigating Hypertensive Disorders of Pregnancy at Very Advanced Maternal Age, from Preconception to Postpartum
Authors: Lopian Miriam , Kashani-Ligumsky Lior , Many Ariel
Published: July 2023

The decision to postpone parenting has gained momentum in recent years, a shift driven by evolving social dynamics and improved access to fertility treatments. Despite their increasing prevalence, pregnancies at advanced maternal ages are associated with increased risks of adverse maternal and neonatal outcomes. This article addresses the association between advanced maternal age and hypertensive disorders of pregnancies (HDPs), which are more prevalent and a significant cause of maternal morbidity and mortality in this population. This review explores the biological mechanisms and age-related risk factors that underpin this increased susceptibility and offers practical management strategies that can be implemented prior to, as well as during, each stage of pregnancy to mitigate the incidence and severity of HDPs in this group. Lastly, this review acknowledges both the short-term and long-term postpartum implications of HDPs in women of advanced maternal age.
Bubble-Based Drug Delivery Systems: Next-Generation Diagnosis to Therapy
Authors: Kancheva Mihaela , Aronson Lauren , Pattilachan Tara , Sautto Francesco , Daines Benjamin , Thommes Donald , Shar Angela , Razavi Mehdi
Published: July 2023

Current radiologic and medication administration is systematic and has widespread side effects; however, the administration of microbubbles and nanobubbles (MNBs) has the possibility to provide therapeutic and diagnostic information without the same ramifications. Microbubbles (MBs), for instance, have been used for ultrasound (US) imaging due to their ability to remain in vessels when exposed to ultrasonic waves. On the other hand, nanobubbles (NBs) can be used for further therapeutic benefits, including chronic treatments for osteoporosis and cancer, gene delivery, and treatment for acute conditions, such as brain infections and urinary tract infections (UTIs). Clinical trials are also being conducted for different administrations and utilizations of MNBs. Overall, there are large horizons for the benefits of MNBs in radiology, general medicine, surgery, and many more medical applications. As such, this review aims to evaluate the most recent publications from 2016 to 2022 to report the current uses and innovations for MNBs.
Interaction of Waves with a Free-Surface Semicircular Breakwater: Experimental Investigation and Empirical Models
Authors: Teh Hee Min , Al-Towayti Faris Ali Hamood , Venugopal Vengatesan , Ma Zhe
Published: July 2023

This experimental study investigated the hydrodynamic performance of the first free-surface semicircular breakwater supported on piles under regular waves. The research focused on SCB models with porosity levels of 0%, 9%, 18%, and 27%. Experimental tests were conducted in a wave flume to evaluate the transmission (CT), reflection (CR), and energy dissipation (CL) coefficients of the SCB models. Wave disturbance coefficients (CF) in front of the breakwater and within the breakwater chamber (CC) were also examined. Horizontal wave loading was measured using normalized force coefficients (Fn), including force coefficients of wave crests (Fn,c) and wave troughs (Fn,t). Empirical formulas were proposed to provide a quick estimate of the hydrodynamic performance, showing good agreement with the measured data. The findings highlight the impact of varying porosity levels on wave attenuation, with the impermeable SCB model (0% porosity) exhibiting superior performance compared to the perforated SCB models. This research contributes valuable insights into optimizing SCB model design and enables efficient estimation of its hydrodynamic performance under regular wave conditions. The results provide valuable guidance for the design and implementation of SCB structures, enhancing their effectiveness in wave attenuation applications.
Assessing Indirect Impacts of Extreme Sea Level Flooding on Critical Infrastructure
Authors: Lan Charles , Wild Alec , Paulik Ryan , Wotherspoon Liam , Zorn Conrad
Published: July 2023

This study investigates the direct and indirect impacts of extreme sea level (ESL) flooding on critical infrastructure. While methods to quantify the direct impacts of ESL flooding on coastal areas are well established, the indirect impacts that extend beyond the directly affected population are less well understood. This study assesses the vulnerability of electricity, road, telecommunication, water supply, and wastewater infrastructure to service disruption from coastal flooding in South Dunedin, New Zealand. We quantified the population affected by single and multiple service losses caused by 100-year average recurrence interval (ARI) ESL flooding across 0.1 m sea-level rise (SLR) increments up to 1.5 m. The study identified an ESL “tipping-point” at 0.6 m SLR, where direct loss of road access and electricity services is extensive, and causes indirect loss of telecommunication services. This also impacted the functionality of a key wastewater pumpstation servicing the wider region. As sea levels in the area are projected to rise 0.60 m in the next ~60–90 years, this information can inform assessments of potential adaptation investments in long-term infrastructure management plans in the face of uncertainty.
AfuPmV-1-Infected Aspergillus fumigatus Is More Susceptible to Stress Than Virus-Free Fungus
Authors: Sass Gabriele , Martinez Marife , Kotta-Loizou Ioly , Stevens David
Published: July 2023

Infection with Aspergillus fumigatus polymycovirus 1 (AfuPmV-1) affects Aspergillus fumigatus Af293’s growth in vitro, iron metabolism, resistance in intermicrobial competition with Pseudomonas aeruginosa, resistance to osmotic stress, and resistance to the chitin synthase inhibitor nikkomycin Z. Here, we show that response to high temperature, Congo Red-induced stress, and hydrogen peroxide are also dependent on the viral infection status of A. fumigatus. AfuPmV-1- infected Af293 was more susceptible than virus-free Af293 to growth inhibition by high temperature, hydrogen peroxide, Congo Red exposure, and nutrient restriction. Increased resistance of virus-free fungus was observed when cultures were started from conidia but, in the case of high temperature and hydrogen peroxide, not when cultures were started from hyphae. This indicates that the virus impairs the stress response during the growth phase of germination of conidia and development into hyphae. In conclusion, our work indicates that AfuPmV-1 infection in A. fumigatus impairs host responses to stress, as shown by exposure to high temperature, oxidative stress such as hydrogen peroxide, and some cell wall stresses, as shown by exposure to Congo Red (in agreement with our previous observations using nikkomycin Z) and nutrient restriction.
The Effects of Option Trading Behavior on Option Prices
Authors: Chen Han-Sheng , Sabherwal Sanjiv
Published: July 2023

This paper investigates the relationship between option trading behavior and option pricing patterns. We argue that greater active trading in the options market due to investor overconfidence leads to higher volatility and larger discrepancies in option pricing, which may be captured by implied volatility spread and implied volatility skewness. Using two different measures of excess option trading, we find that trading activities are correlated in different ways with volatility, volatility spread, and volatility skewness. We also find that these relationships exist both over time and cross-sectionally. We suggest that options investors tend to chase “hot” stocks, as we find evidence of a positive relationship between option trading activities and past underlying equity returns. Heavier trading in the options market also tends to make out-of-the-money call options more (less) expensive than the at-the-money counterparts over time (cross-sectionally). Because trading activities do not predict future equity returns, investor overconfidence, and not informed trading, seems to be a more plausible explanation for our findings.
Experimental Study of the Rheology of Grease by the Example of CIATIM-221 and Identification of Its Behavior Model
Authors: Nosov Yuriy O. , Kamenskikh Anna A.
Published: July 2023

The study of the rheological properties of a lubricant allows for the assessment of the structure’s durability in which they are used. Computer engineering enables the prediction of the structure performance using refined mathematical models of its materials. This paper presents an experimental investigation of the rheological behavior of a lubricant that is actively used in bridge structures. The paper proposed a methodology for determining the rheological characteristics of the lubricant using a rotational viscometer. Additionally, the article performed the task of identifying the mathematical model of the lubricant behavior based on the Maxwell body, using two approaches: the Anand model and the Prony series. The proposed models allow for numerical modeling of the structure’s performance throughout their lifecycle within the scope of computer engineering.
Tribological and Micro-Mechanical Properties of Injected Polypropylene Modified by Electron Radiation
Authors: Ovsik Martin , Stanek Michal , Dockal Adam
Published: July 2023

Today, more and more importance is given to the improvement of polymer materials’ wear resistance, i.e., their micro-mechanical and tribological properties, which could widen their application in practice. The properties of materials can be modified by several methods, among them exposure to electron radiation. This study focuses on the effect of varying radiation intensity (15 kGy to 99 kGy), depth of penetration, and subsequent structure modification of injection-molded polypropylene on tribological and micro-mechanical properties. Electron radiation influences the structure of individual layers, thus improving or degrading their properties. Hence, the depth of penetration can be examined by instrumented hardness tests and scratch tests. Due to irradiation, surface properties and wear resistance increased by up to 105% (from 38 MPa to 78 MPa). As the results show, an increase in mechanical properties was recorded in the direction towards the center of the sample (from 72 MPa to 82 MPa). Micro-mechanical tests were also confirmed by the observation of cross-linking changes (gel test) as well as crystallinity increases (wide-angle X-ray diffraction and microtome cuts). This finding could have a significant effect on the manufacturing and subsequent modification of injection-molded polypropylene parts, which opens new possibilities in practice for this material. The increased surface wear resistance enables the use of parts for which the durability and abrasion resistance of the surface are demanded, especially in applications facing exposure to long-term cyclical loads (e.g., gears).
Characterization of Structural, Optical, Corrosion, and Mechanical Properties of HfO2 Thin Films Deposited Using Pulsed DC Magnetron Sputtering
Authors: Mańkowska Ewa , Mazur Michał , Kalisz Małgorzata , Grobelny Marcin , Domaradzki Jarosław , Wojcieszak Damian
Published: July 2023

Various properties of HfO2, such as hardness, corrosion, or electrical resistance, depend on the method and the conditions of deposition. In this work, a thorough comparison of scarcely investigated mechanical properties of HfO2 thin films deposited with different conditions of reactive magnetron sputtering process is presented. Four thin films were sputtered in processes that varied in plasma ignition method (continuous or sequential) and target–substrate distance. The structural characteristics of the HfO2 thin films were examined using Raman spectroscopy and X-ray diffraction measurements. Furthermore, the optoelectronic properties were determined based on transmittance and current–voltage characteristics. The mechanical properties of the HfO2 thin films were determined using nanoindentation and scratch test. In turn, the corrosion properties were determined by analyzing the voltametric curves. The transparent HfO2 thin films deposited in the continuous process are characterized by better corrosion resistance than the same layer formed in the sequential process, regardless of the target–substrate distance (8 cm or 12 cm). Furthermore, these samples are also characterized by the highest value of Young’s modulus and scratch resistance. The combination of good corrosion and scratch resistance could contribute to the new application of HfO2 as a corrosion protective material.
Electronic and Transport Properties of Strained and Unstrained Ge2Sb2Te5: A DFT Investigation
Authors: Tian Jing , Ma Weiliang , Boulet Pascal , Record Marie-Christine
Published: July 2023

In recent years, layered chalcogenides have attracted interest for their appealing thermoelectric properties. We investigated the Ge2Sb2Te5 compound in two different stacking sequences, named stacking 1 (S1) and stacking 2 (S2), wherein the Ge and Sb atomic positions can be interchanged in the structure. The compound unit cell, comprising nine atoms, is made of two layers separated by a gap. We show, using the quantum theory of atoms in molecules, that the bonding across the layers has characteristics of transit region bonding, though with a close resemblance to closed-shell bonding. Both S1 and S2 are shown to bear a similar small gap. The full determination of their thermoelectric properties, including the Seebeck coefficient, electrical conductivity and electronic and lattice thermal conductivities, was carried out by solving the Boltzmann transport equation. We show that stacking 1 exhibits a larger Seebeck coefficient and smaller electrical conductivity than stacking 2, which is related to their small electronic gap difference, and that S1 is more suitable for thermoelectric application than S2. Moreover, under certain conditions of temperature and doping level, it could be possible to use S1-Ge2Sb2Te5 as both a p and n leg in a thermoelectric converter. Under biaxial, tensile and compressive strains, we observe that the thermoelectric properties are improved for both S1 and S2. Furthermore, the increase in the power factor of S1 in the cross-plane direction, namely perpendicular to the gap between the layers, shows that strains can counteract the electronic transport hindrance due to the gap.
Effect of Cold Drawing and Annealing in Thermomechanical Treatment Route on the Microstructure and Functional Properties of Superelastic Ti-Zr-Nb Alloy
Authors: Kudryashova Anastasia , Lukashevich Konstantin , Derkach Mikhail , Strakhov Oleg , Dubinskiy Sergey , Andreev Vladimir , Prokoshkin Sergey , Sheremetyev Vadim
Published: July 2023

In this study, a superelastic Ti-18Zr-15Nb (at. %) alloy was subjected to thermomechanical treatment, including cold rotary forging, intermediate annealing, cold drawing, post-deformation annealing, and additional low-temperature aging. As a result of intermediate annealing, two structures of β-phase were obtained: a fine-grained structure (d ≈ 3 µm) and a coarse-grained structure (d ≈ 11 µm). Cold drawing promotes grain elongation in the drawing direction; in a fine-grained state, grains form with a size of 4 × 2 µm, and in a coarse-grained state, they grow with a size of 16 × 6 µm. Post-deformation annealing (PDA) at 550 °C for 30 min leads to grain sizes of 5 µm and 3 µm, respectively. After PDA at 550 °C (30 min) in the fine-grained state, the wire exhibits high tensile strength (UTS = 624 MPa), highest elongation to failure (δ ≥ 8%), and maximum difference between the dislocation and transformation yield stresses, as well as the highest superelastic recovery strain (εrSE ≥ 3.3%) and total elastic + superelastic recovery strain (εrel+SE ≥ 5.4%). Additional low-temperature aging at 300 °C for 30–180 min leads to ω-phase formation, alloy hardening, embrittlement, and a significant decrease in superelastic recovery strain.
Study of the Aid Effect of CuO-TiO2-Nb2O5 on the Dielectric and Structural Properties of Alumina Ceramics
Authors: Shakirzyanov Rafael I. , Volodina Natalia O. , Kadyrzhanov Kayrat K. , Kozlovskiy Artem L. , Shlimas Dmitriy I. , Baimbetova Gulzada A. , Borgekov Daryn B. , Zdorovets Maxim V.
Published: July 2023

The aim of this work is to study the structural, dielectric, and mechanical properties of aluminum oxide ceramics with the triple sintering additive 4CuO-TiO2-2Nb2O5. With an increase in sintering temperature from 1050 to 1500 °C, the average grain size and the microhardness value at a load of 100 N (HV0.1) increased with increasing density. It has been shown that at a sintering temperature of 1300 °C, the addition of a 4CuO-TiO2-2Nb2O5 additive increases the low-frequency permittivity (2–500 Hz) in alumina ceramic by more than an order of magnitude due to the presence of a quadruple perovskite phase. At the same time, the density of such ceramics reached 89% of the theoretical density of α-Al2O3, and the microhardness value HV0.1 was 1344. It was observed that the introduction of 5 wt.% 4CuO-TiO2-2Nb2O5 in the raw mixture remarkably increases values of shrinkage and density of sintered ceramics. Overall, the results of this work confirmed that introducing the 4CuO-TiO2-2Nb2O5 sintering additive in the standard solid-phase ceramics route can significantly reduce the processing temperature of alumina ceramics, even when micron-sized powders are used as a starting material. The obtained samples demonstrated the potential of α-Al2O3 with the triple additive in such applications as electronics, microwave technology, and nuclear power engineering.