bluuebunny/crossref_metadata_2025 huggingface dataset:
Premedication of Ranitidine and the Action of Hypersensitivity Reactions to Paclitaxel
Authors: Brahmbhatt Harsh K , Patel Nidhi , Patel Tejas K , Sarkar Tantul
Published: January 2024

Paclitaxel is used asa chemotherapeutic agent for curing various types of cancer. To reduce the hypersensitivity of the chemotherapeutic effect, premedication of antihistaminic drugs like ranitidine, cetirizine, diphenhydramine, fexofenadine and desloratadine are prescribed. The antihistaminic drugs are given as premedication to prevent the formation of hives on the body. Ranitidine can be replaced by another antihistaminic drug which reduces the side effects and increases the efficacy of the drug. Studies were conducted comparing the antihistamine and non-antihistamine groups and tests like the chi-square test, and the Wilcoxon-Mann-Whitney test to determine the extent of hypersensitivity. There are immediate and non-immediate drug hypersensitivity reactions occurring in cells that initiate the allergic reaction. These allergic reactions like flushing, itching, dizziness, nausea, vomiting, swelling, etc lead to affect the respiratory, cardiovascular, gastrointestinal, and other body parts. In this article, the method used for the study of hypersensitivity reaction is specified with the test to determine the allergic reaction on the skin and desensitization of the rapid hypersensitivity of the drug.
Thevetia peruviana: Its Phytochemistry, Traditional and Medicinal Uses, and Pharmacological Activities
Authors: Chauhan V Singh , Mazumder Avijit , Chandel Shobhini
Published: January 2024

Thevetia peruviana, a member of the Apocynaceae family, is also known as digoxin, fortunate nut, yellow oleander, and other names. After consumption, T. peruviana plants have the potential to be fatal. In South Asian countries, especially in Sri Lanka and India, T. peruviana is frequently used for international self-harm. Around the world’s tropical and subtropical regions, T. peruviana is a common cause of toxicological emergencies. The entire plant is hazardous due to the presence of several cardiac glycosides, including neriifolin, oleandrin, thevetin A, and thevetin B. Oleander consumption causes hyperkalemia, vomiting, diarrhea, abdominal pain, and all of the above. In the majority of cases, supportive care and the administration of activated charcoal are used in the clinical therapy of either N. oleander or T. peruviana poisoning. T. peruviana-related information is compiled in this article.
A randomized controlled trial of nurse-led Brief Focused Intervention for patients with alcohol use-related mild traumatic brain injury in the emergency and casualty services of a tertiary hospital
Authors: Pavalur Rajitha , Nattala Prasanthi , Kandasamy Arun , Shukla Dhaval P.
Published: January 2024

Objectives:

Driving under the influence of alcohol is one of the leading causes of road traffic accidents in India. Individuals with acute injuries often present to emergency hospital services. Carrying out brief interventions in the emergency can prevent further injury and even progression to severe patterns of drinking. However, there are no known studies from India examining the effectiveness of such interventions in emergency settings. Against this background, the objective of this randomized controlled trial was to evaluate the effectiveness of a nurse-led Brief Focused Intervention (BFI) in comparison with the minimal intervention for patients with mild Traumatic Brain Injury (TBI) reporting to the emergency and casualty services of a tertiary hospital in Bengaluru, South India, who screened positive for alcohol use.

Materials and Methods:

The BFI comprised a video portraying the effects of alcohol on the brain and muscles and brief advice on how to reduce or avoid alcohol use. Subjects (N = 90) were randomly allocated to two groups: BFI (n = 45) or Minimal Intervention Group (MIG) (n = 45). Standardized tools were used to assess both groups on specific outcomes for up to six months following discharge from the emergency and casualty services. At the end of six months, complete data wasavailable for 73 patients.

Results:

Participants’ (N = 73) mean age was 35 years (standard deviation [SD]-11). Over the six-month follow-up, the BFI group reported significantly lesser quantity of alcohol consumption (Alcohol Use Disorder Identification Test [AUDIT] Score – 5.03, SD 4.09, 95% confidence interval [CI] = 3.70, 6.35) compared to MIG (AUDIT Score – 9.76, SD 2.96, 95% CI = 8.73, 10.80), and fewer alcohol use-related problems in BFI group (Mean – 4.18, SD 3.21, 95% CI = 3.14, 5.22) compared to MIG (Mean – 5.88, SD 2.59, 95% CI = 4.98, 6.79). Results of logistic regression showed that being in MIG as well as baseline hazardous use of alcohol were associated with unfavorable outcomes at the end of six months follow-up.

Conclusion:

Findings provide the first known evidence from India for the effectiveness of nurse-led BFI in the emergency and casualty services in improving post-discharge outcomes for patients with alcohol use-related mild TBI. While the findings of the study are statistically significant, these findings also have significant clinical relevance, as they have shown that the BFI improved clinical outcomes. Thus, brief interventions should be implemented for these patients whenever possible in the Emergency setting.
Neutrophilic dermatosis of dorsal hands: A unilateral presentation
Authors: Joseph Anju , Pappen Thankappan Thonduparampil , Kunjukunju Balachandran Parapattu , Mathew Leny , Jayaprakash Anjana
Published: January 2024

A rare localized version of Sweet syndrome known as neutrophilic dermatosis of dorsal hands is characterized by bluish or hemorrhagic papules, bullae, and nodules on the dorsal hands. Cases have been associated with myeloproliferative disorders, malignancy, inflammatory bowel disease, and rheumatoid arthritis. We are reporting a case of a 39-year-old male presented with sudden onset hyperpigmented raised lesions studded with fluid-filled vesicles on the left dorsal hands. Histology confirmed the clinical diagnosis of neutrophilic dermatosis of dorsal hands. Unilateral presentation of neutrophilic dermatosis of dorsal hands is rarely encountered in day-to-day practice. Hence, we are reporting this case.
Physicochemical characteristics and antioxidant activity of Kimchi manufactured salted cabbages in different cultivation areas
Authors:   The Table and Food Coordinate Society of Korea, Jung Min Seo , Kim Soo Hyun , Jeon Moon Hee , Lee Seung Lim
Published: January 2024

In this study, Kimchi was made using salted cabbages from different cultivation areas, stored at 5°C for three days, and analyzed for its physicochemical characteristics. Additionally, Kimchi was prepared using a 95% edible liquor extract to determine its antioxidant activity. While no significant differences were observed in salinity and sugar content across the Kimchi samples, notable differences in pH and acidity were found. The free amino acid contents of Kimchi A and Kimchi B were similar, at 5,900.8 mg/100 g and 5,934.2 mg/100 g, respectively. Weissella koreensis was a predominant strain in both Kimchi samples. Kimchi B exhibited significantly higher total polyphenol and flavonoid contents, measured at 37.62±0.71 mg/g and 9.06±0.58 mg/g, respectively, compared to Kimchi A. Furthermore, Kimchi B demonstrated greater DPPH radical scavenging activity, with percentages of 25.71±0.07% and 46.12±0.34% at concentrations of 2.5 mg/mL and 5 mg/mL, respectively. At a concentration of 5 mg/mL, Kimchi B's absorbance was 3.062±0.061, approximately three times higher than that of Kimchi A. Consequently, these findings provide essential data for the fermentation process and development of Kimchi using salted cabbages from different cultivation areas.
Acculturation of Chinese migrant employees in the hospitality industry of South Korea: a profiling study
Authors:   The Table and Food Coordinate Society of Korea, k k , k k , Kang Byung-Yong , Kim Suk-Hyun
Published: January 2024

This study investigates the acculturation process of Generation MZ Chinese migrant workers in the South Korean hospitality industry, focusing on their experiences in overcoming language barriers and cultural differences. Employing snowball sampling, the study gathered data through online questionnaires from Chinese employees working in South Korea's hotels and restaurants, yielding 312 valid responses. The findings highlight the influence of individualism-collectivism orientations on acculturation strategies. Workers with a tendency towards horizontal individualism and collectivism generally prefer assimilation, whereas those with a vertical individualism orientation lean towards marginalization. Interestingly, vertical collectivists, who value social hierarchy and group responsibility, show a predilection for both segregation and integration strategies, underscoring the complex nature of acculturation. The study also found that educational level, Korean language proficiency, and length of stay in Korea significantly affect their acculturation strategy choices. Based on these findings, the study provides vital insights into the adaptation processes of Chinese migrant workers in South Korea's hospitality industry and offers theoretical and practical guidance for effectively recruiting and managing foreign employees, particularly those from China.
High Energy Density and High Cycle Stability SiO Anodes Material Co-Doping with Graphene and Lithium Silicon Alloy
Authors: Wong Iok Hei , Ho Kai Meng , Sou Choi Ngo
Published: January 2024

we use SiO and Li₁₃Si₄ (lithium accounted for 10% of the mass fraction of the whole material) in a closed space to weigh and mix after ball milling, and then heated at 750 and 950 degrees Celsius respectively. Try to use the mechanical encapsulation of lamellar graphene to cover the mixed material of SiO and Li₁₃Si₄, so as to try to improve SiO-based anode performance. Both graphene and lithium silicon alloy will contribute to the higher reversible capacity and long-term stability, realizing the application of SiO anodes.
Photodegradable glyco-microfibers fabricated by the self-assembly of cellobiose derivatives bearing nitrobenzyl groups
Authors: Okumura Bioru , Yamaguchi Eriko , Komura Naoko , Ohtomi Taku , Kawano Shin-ichiro , Katagiri Hiroshi , Ando Hiromune , Ikeda Masato
Published: January 2024

Stimuli-responsive materials constructed via the self-assembly of small biomolecules are attracting increasing attention because of their biocompatibility, sustainability, and variety of (bio)applications. Nevertheless, the research on oligosaccharide-based molecular designs for such stimuli-responsive materials (or stimuli-responsive glyco-materials) is limited, partly due to the intrinsic structural diversity of oligosaccharides and the difficulty associated with their selective chemical syntheses. Herein, we report the construction of photodegradable glyco-microfibers by the self-assembly of cellobiose derivatives bearing nitrobenzyl groups. The atomic-scale, self-assembled architecture of the photodegradable glyco-microfibers is unveiled and compared with those of pristine cellobiose and cellulose polymorphs in previous reports.
Electronic structure characterization by photoelectron spectroscopy of BaZrS3 perovskite powder and thin film
Authors: Riva Stefania , Mukherjee Soham , Butorin Sergei M. , Allan Abdel R. , Comparotto Corrado , Aggarwal Garima , Johannesson Evelyn , Abdel-Hafiez Mahmoud , Scragg Jonathan , Rensmo Håkan
Published: January 2024

Chalcogenide perovskites exhibit optoelectronic properties that position them as breakthrough materials in the field of photovoltaics. We report a detailed investigation into the electronic structure and chemical properties (XPS) of polycrystalline BaZrS3 perovskite powder, complemented by an analysis of their geometric atomic arrangement using XRD and XAS. The results are compared with measurements on sputtered polycrystalline BaZrS3 thin film prepared through rapid thermal processing. Moreover, we establish a correlation between the experimental valence band spectra and the theoretical density of states derived from DFT calculations, thereby discerning the orbital constituents involved. While bulk characterization confirms the good quality of the powder, depth-profiling achieved by photoelectron spectroscopy utilizing Al Kα (1.487 keV) and Ga Kα (9.25 keV) radiations shows that, regardless of the fabrication method, the oxidation effects extend beyond 10 nm from the sample surface, with specifically zirconium oxides occurring deeper than the oxidized sulfur species. The hard X-ray photoelectron spectroscopy study on the powder and thin film detects signals with minimal contamination contributions and allows the determination of the valence band maximum position with respect to the Fermi level. Our analysis gives an improved understanding of the electronic structure of BaZrS3, linking the electronic structure of this semiconductor to the fundamental bonding properties of the material, providing knowledge which is crucial for interfaces development, and consequently, for device integration.
Composition effects of electrodeposited Cu-Ag nanostructured electrocatalysts for CO2 reduction
Authors: Plaza-Mayoral Elena , Okatenko Valery , Dalby Kim Nicole , Falsig Hanne , Chorkendorff Ib , Sebastian-Pascual Paula , Escudero-Escribano Maria
Published: January 2024

The electrochemical reduction of carbon dioxide (CO2RR) to valuable C2+ liquid fuels and oxygenates, such as ethanol and propanol, is a promising strategy to minimize the carbon footprint and store renewable electricity. In this study, we investigate the CO2RR on electrodeposited Cu-Ag nanostructures obtained using a green choline chloride and urea deep eutectic solvent (DES). We show that Cu-Ag nanostructured electrocatalysts with tunable composition, loadings, and size can be simply prepared in one step, without adding other additives or surfactant agents. We investigate the intrinsic activity and selectivity of the CO2RR by determining the electrochemically active surface area (ECSA) using lead underpotential deposition (UPD). The analysis of the partial current densities normalized by the ECSA shows that the addition of Ag on electrodeposited Cu primarily suppresses the production of hydrogen and methane with respect to Cu nanostructures. At the same time, the production of carbon monoxide (CO) slightly increases but, the partial current of the total C2+ products does not considerably increase. Despite that the production rate of C2+ is similar on Cu and CuAg, the addition of Ag enhances the formation of alcohols and oxygenates over ethylene, in line with previous reports. We highlight the potential of metal electrodeposition from DES as a sustainable and inexpensive strategy for the development of bimetallic Cu-based nanocatalysts towards CO2RR.
A CASE STUDY ON THE TRADE OF MANGOES IN NEPAL
Authors: Awasthi Prakash , Bogati Sujan , Adhikari Suman , Kunwar Aashish , Bhandari Riya , Chataut Gopi , Joshi Dipesh
Published: January 2024

Given the country’s advantageous agro-climatic conditions that promote the development of premium mango types, Nepal’s mango industry has attracted a lot of interest. To examine the trade dynamics of Nepalese mangoes, this study will look at production trends, varietal diversity, post-harvest procedures, and problems with market access. The complex regulatory system that governs mango exports and the numerous difficulties that mango growers and exporters face are given special attention. These difficulties include market access difficulties, logistical bottlenecks, infrastructure constraints, and the unavoidable requirement for conformity with international quality standards. The tremendous prospects that still exist for increasing mango exports from Nepal are also highlighted by this study. These include taking advantage of nearby markets like India, broadening product lines with value-added mango products, and taking advantage of the rising demand for organic and exotic fruits around the world. The report also emphasizes how crucial government support programs and public-private partnerships have been in promoting the expansion of the mango trade.
ECONOMIC RESILIENCE AND THE METAL INDUSTRY: A QUALITATIVE EXAMINATION OF DHAKA'S METAL BUSINESSES IN RESPONSE TO FLUCTUATING ECONOMIC CONDITIONS
Authors: Hasan Md Mehedi , Nipa Meherun Nisa , Abtahi Ahanaf Tahmid , Jalal Siam Saleh Ahmed
Published: January 2024

This study delves into the intricate interplay between the economic environment and Metal Industry’s profitability and growth. Metal Industry, a prominent steel manufacturing company, operates in a complex global landscape, necessitating a comprehensive understanding of economic factors that influence its trajectory. Through qualitative research methods, including interviews and document analysis, key personnel’s perspectives within the company were garnered. The economic environment’s role in shaping profitability and growth was scrutinized, uncovering critical insights. The study reveals that economic variables, encompassing inflation, interest rates, and exchange rates, exert a significant impact on production costs, demand dynamics, and pricing strategies. The company’s adaptive measures, as illuminated in response to economic trends and events, underscore its resilience and strategic agility. Challenges posed by factors like increased competition, raw material costs, and trade policy shifts were identified, alongside opportunities such as market expansion and sustainability initiatives. Ethical practices were highlighted as integral to the company’s approach, manifesting through sustainable production, regulatory compliance, stakeholder engagement, and responsible sourcing. The study’s findings provide a multi-dimensional perspective on how Metal Industry navigates economic complexities, proactively responds to challenges, and ethically positions itself for sustainable profitability and growth. The insights garnered contribute to a nuanced comprehension of the dynamic relationship between businesses and the economic landscape.
Auckland Regional Cleft Palate Service: service accessibility and speech outcomes
Authors: Street Melanie , Miles Anna
Published: January 2024

aim: This study explored speech outcomes for five-year-olds born with cleft palate residing in the Auckland Regional Cleft Palate Service catchment, with a focus on ethnicity and geographical influences on service accessibility and speech outcomes. method: A retrospective audit of children born with cleft palate between 2013–2016 was conducted (n=89), including secondary surgeries, ethnicity, distances travelled, services offered and attended. Speech outcomes at five years were compared to international benchmarking. results: Seventy-nine children were included; 10 were lost to follow-up before their 5 years review. At 5 years, 30% children presented with moderate to severe velopharyngeal incompetence; 30% had residual cleft speech characteristics which warranted speech therapy intervention. There was no significant difference in speech outcomes for Māori vs non-Māori. Attendance at clinic was not significantly associated with distance from centre. However, Māori had significantly lower attendance at clinic appointments and were significantly more likely to be referred to community services. conclusion: Auckland Regional speech outcomes are better than the national average, yet still do not compare favourably with international benchmarking. While speech outcomes were not associated with ethnicity, attendance at specialist clinic appointments was lower in Māori. Community services were offered, but attendance at, and satisfaction with, these appointments is unknown. Further work is needed to reach all children regionally in a timely manner to ensure Aotearoa New Zealand speech outcomes meet international standards.
Patient experience surveys are vital in the twenty-first century: let’s put some myths to rest
Authors: Catherine Gerard Catherine , O’Brien Inga , Shuker Carl , Swanson Jo , Hamblin Richard
Published: January 2024

Patient-reported data derived from surveys places patient feedback at the heart of quality improvement and health system responsiveness. Such surveys are not without critics, however, who contend that there are better ways to collect feedback. Criticisms assert that response rates are too low and measures are not robust, valid or reliable, that patient experience surveys are neither valid nor reliable for Māori and Pacific peoples and that such surveys do not contribute to improved outcomes for patients. We debunk these myths in the context of the Te Tāhū Hauora Health Quality & Safety Commission (Te Tāhū Hauora) patient experience survey programme. We explain the centrality of a strong consumer and whānau voice in a twenty-first century health system, and that listening to and acting on this voice—including use of patient-reported data—is now a statutory requirement for health entities under the Pae Ora (Healthy Futures) Act 2022. We describe the different surveys in the programme and explain the differences between patient satisfaction and patient experience. We address sample size and response rates, including representativeness in the surveys of Māori and Pacific peoples’ experience. We look at how survey data can be used for quality improvement and to guide us toward providing equitable, culturally safe care. We assert that, contrary to criticisms, the programme delivers valid, reliable, relevant, systematic and practical patient experience surveys and resulting data, with guides for improvement, and that we are both legally and ethically bound to listen to and use these results to improve the healthcare we deliver.
The deconstruction of chronic orofacial pain and a hiding inhibition pathway of orofacial pain: the trigeminal proprioceptive mesencephalic periaqueductal gray pathway
Authors: Polonowita Ajith , Mei Li , Guan Guangzhao
Published: January 2024

Chronic orofacial pain has a significant negative impact that influences individuals’ quality of life and our society. The prevalence is around 11.2% to 33.2% and remains high in females. Currently, there are two main diagnostic classification systems that are used internationally for chronic pain: the International Classification of Diseases, 11th Revision (ICD-11), which was published by the World Health Organization (WHO) in 2018, and the International Classification of Orofacial Pain, which was published by the International Association for the Study of Pain (IASP) in 2020. Deficits in ascending and descending pain modulation pathways may be involved in the chronic pain pathophysiology. A newly described “trigeminal proprioceptive mesencephalic periaqueductal gray pathway” is considered to be the mechanism of action of occlusal appliance in managing orofacial pain. The genetic basis of chronic orofacial pain is not yet fully understood, but a genetic susceptibility involving multiple genes among the peripheral nerves, brainstem and higher brain regions to regulate and suppress the transmission of pain signals, thereby modulating the perception of pain, is likely.
ANALISIS PEMILIHAN MODA TRANSPORTASI UMUM MENUJU STASIUN GAMBIR MENGGUNAKAN TRANSPORTASI ONLINE DAN BUS TRANSJAKARTA
Authors: Ferdiansyah Ridho , Rizani Mohammad Debby , Yudaningrum Farida
Published: January 2024

Public transportation acts as a sustainable mode of transportation to reduce the increasing level of pollution and traffic congestion. Public transportation has many types, in Jakarta, for example, online transportation and Transjakarta buses. This study aims to analyze the characteristics of online transportation travellers and Transjakarta buses, analyze the chances of choosing between the two modes of public transportation, and determine the level of service according to the community. Data collection using questionnaires distributed at Gambir station. Characteristics of travelers were analyzed using descriptive statistics. The probability of choosing a mode is analyzed using the binary logit difference model with the help of multiple linear regression equations. The level of service of the two modes of public transportation was analyzed using a Likert scale. The results showed that the characteristics of online transportation travellers are dominated by female, of productive age, highly educated, worked as an employee, earned quite a lot of money, traveled for vacation or recreational purposes, and the reason for choosing the mode was getting to the destination quickly. The characteristics of Transjakarta bus travellers are dominated by male, productive age, highly educated, work as an employee, earn quite high, travel for vacation or recreational purposes, and the reason for choosing the mode is the low price. The dominant choice of public transportation mode is online transportation. The level of online transportation services for the security and convenience aspects is in the good category, and the ease and reliability aspects are in the very good category.Keywords: characteristics of travellers, transportation mode, likert scale
KERUGIAN BBM AKIBAT TUNDAAN DAN PANJANG ANTRIAN DI PERSIMPANGAN JALAN RAYA DENGAN REL KERETA API SEBIDANG (Studi Kasus Jalan Hasanudin Semarang)
Authors: Ananda Fina Kurnia , Yaqin Wafi Ainul , Rizani Mohammad Debby , Yudaningrum Farida
Published: January 2024

Due to the high mobility of those passing by and the presence of trains that cross the intersection between the highway and the railroad, also known as level crossings, Jalan Hasanudin experiences heavy traffic during rush hour. Additionally, because of the large volume of train traffic at the Poncol station and the proximity of this intersection to the station, there is frequently a buildup of vehicles at the level crossing on Jalan Hasanudin. As a result, researchers will determine how Jalan Hasanudin Semarang performed. After conducting research, it was discovered that the highest vehicle queue length occurred on Monday, February 27 2023 from Jalan Hasanudin - Imam Bonjol at closing time 16.45 with a queue length of 123 meters and the highest stop delay occurred on Saturday, March 4 2023 from the direction of Jalan Hasanudin - Imam Bonjol with an average stop delay duration of 372.00 seconds. Therefore, the occurrence of long lines led to fuel losses for the drivers; their total gasoline loss over the course of the three research days was IDR 886,550.7. The researchers offer recommendations based on the findings of the research analysis to control street vendors and people near railroad tracks and railroad crossings that result in side barriers and long lines during stop delays, install traffic signs like those that prohibit stopping, prohibit parking, and prohibit raising and lowering passengers on roads, and so that there is no congestion along Jalan Hasanudin and around railroad crossings.
AUSTROASIATIC ROOTS OF SORA MYTHOLOGY. ORIGIN AND DEVELOPMENT OF THE IMAGE OF THE GOD KITTUNG (ETHNOLINGUISTIC ANALYSIS)
Authors:   Institute of Linguistics of the Russian Academy of Sciences, Renkovskaya Evgeniya A.
Published: January 2024

The article deals with the origin and development of the image ofthe god Kittung in the traditional Sora beliefs, as well as its transformation in the “new” religions that arose among the Sora as a result of active proselytism. Based on ethnolinguistic as well as comparative mythological analysis, the paper concludes that the god Kittung goes back to the Austroasiatic mythological ancestor deity, who escaped during the Deluge inside a giant gourd and recreated all life anew. At the same time, the “gourd” anthropogenic myth has a large number of parallels in Southeast Asia and southern China, so it can be assumed that the myth of Kittung dates back in time to the migrations of the Munda peoples to India. In the 20th century, Kittung goes beyond traditional beliefs and becomes God in Christianity and the supreme deity in neo-Hinduism, and is also embodied in one of the letters of the sacred alphabet of the Mattar Banom cult.
Spontaneous and stimulated platelet aggregation activity in patients with atrial fibrillation and thrombotic complications
Authors: Sitkova E. S. , Dragunova M. A. , Ogurkova O. N. , Smorgon A. V. , Moskovskikh T. V. , Batalov R. E. , Suslova T. E.
Published: January 2024

Aim: To study spontaneous and stimulated by adenosine diphosphate (ADP), adrenaline and collagen platelet aggregation activity, CD40-CD40 ligand system in patients with atrial fibrillation (AF) with previous thromboembolic complications (TEC) and newly diagnosed thrombosis.

Material and Methods. The study included patients with «non-valvular» AF and anamnesis of TEC and newly identified thrombosis on anticoagulants in the period 01.2020-01.2023: 13 patients had anamnesis of TEC (group 1), in 18 patients were initially diagnosed thrombosis/spontaneous atrial echocontrast of high grade (group 2). The comparison group was the healthy individuals (n = 31) (group 3). The spontaneous aggregation ability of platelets and stimulated with solutions of ADP, adrenaline and collagen, the level of CD40 markers, soluble CD40 ligand (CD40L) were studied.

Results. The spontaneous platelet aggregation activity was significantly higher in patients of group 2 compared with healthy individuals with a formation trend of larger aggregates in patients with TEC. When aggregation was induced by collagen, the rate of aggregate formation was significantly lower in the 1st and 2nd groups compared with healthy individuals. When using ADP, a comparable decrease in the degree and speed was noted, and when using adrenaline, only the rate of platelet aggregation was observed in groups 1 and 2. The concentration of soluble CD40L was significantly higher in patients with a history of TEC and newly thrombosis.

Conclusion. Spontaneous platelet aggregation activity and the concentration of soluble CD40L are increased both in patients with past of TEC and in patients with newly diagnosed thrombosis due to AF and anticoagulant monotherapy.
Peripheral embolism and microcirculation during revascularization of the superficial femoral artery with native and drug-coated balloons over a one-year follow-up period
Authors: Gostev A. A. , Osipova O. S. , Klinkova A. S. , Kamenskaya O. V. , Karpenko A. A.
Published: January 2024

Relevance. The embolic effect of drug-coated balloons has only been demonstrated in preclinical studies.

Aim: To identify intraoperative distal embolism when using drug-coated balloons during revascularization of the superficial femoral artery. To evaluate the effect of drug embolism on microcirculation of the lower extremities within 12 months after treatment.

Material and Methods. Prospective, randomized, single-center pilot study. Twenty patients with symptomatic atherosclerotic femoro-popliteal above the knee lesions were included in the study. The first group underwent percutaneous transluminal angioplasty (PTA) using a drug-coated balloon (DCB), the second group – using a non-drug-coated conventional balloon (CB).

Results. During intraoperative detection of emboli, distal microembolism was recorded in 10 patients (100%) in the DCB group (median number of emboli = 200) and in 8 patients (80%) in the CB group (median number of emboli = 135), p = 0.47. Primary patency in the DCB group was 100%, in the CB group 60% (p log-rank = 0.02). In the shin there was increase in TcPO2 by 12.2% in the DCB group (p = 0.42), and by 37.1% in the CB group (p = 0.001). At the same time, according to the results of TcPO2 on the shin in the DCB group, there was first a slight decrease in indicators compared to the preoperative level by 6% (p = 0.64), followed by an increase of 12.2% after 12 months of observation (p = 0.22). In the DCB group, the sum of SF-36 questionnaire points increased by 22.7% (p = 0.017), and by 25.3% in the CB group, compared to baseline values respectively (p = 0.04).

Conclusion. When using DCB, there is a tendency towards a higher incidence of intraoperative distal embolism and the number of emboli compared with CB. The results of microcirculation studies suggest the presence of distal drug-coated embolism in DCB group.
On the cardiovascular effects mechanism of humic nature macromolecular compounds
Authors: Lasukova T. V. , Zykova M. V. , Azarkina L. A. , Gorbunov A. S. , Petrova I. V. , Karpova M. R.
Published: January 2024

Introduction. The search for new drugs to reduce effectively myocardial damage during ischemia and reoxygenation is relevant considering that many pharmacological drugs have a number of limitations for patients and their use is accompanied by negative side effects.

Aim: To assess the NO-synthase possible role in the cardiovascular effects mechanism of the standardized active pharmaceutical substance (AFS) of the humic acids (HA) isolated from peat.

Material and Methods. The experiments were carried out on the isolated perfused rat heart model using the Langendorff method. We studied the effect of a standardized sample of peat HA at concentrations of 0.001; 0.01; 0.1 mg/ml on coronary perfusion rate and myocardial contractility parameters. To assess the NO-synthase value in the HA effects realization, the enzyme was pre-inhibited using L-NAME (10 µM/L) before the test sample addition.

Results. HA sample using contributed to an effective increase in the heart coronary perfusion rate due to the NO-synthase signaling mechanism activation. There was some decrease in contractility and end-diastolic pressure associated with the NOsynthase activation because the enzyme inhibition with L-NAME removed all effects of the test HA sample.

Conclusion. The obtained data show to the peat HA have vasodilating properties associated with the NO-synthase activation. The such effect presence indicates on the prospects for further investigation of these compounds cardiotropic properties in the order developing new effective means for improving intracardiac hemodynamics and limiting Ca2+ overload of cardiomyocytes in conditions of ischemia and reperfusion.
Medical center for remote monitoring of patients with COVID-19 as a key element in reducing the burden on the ambulance service during the pandemic
Authors: Baranovskaya S. V. , Sirotina A. S. , Kobyakova O. S. , Boykov V. A. , Deev I. A. , Shibalkov I. P. , Babeshina M. A. , Tskhai V. F.
Published: January 2024

Background. During the COVID-19 pandemic, remote consulting and monitoring technologies began to be used in medical practice to maintain the proper level of quality of patient care, ensure the efficient use of emergency medical teams (EMT) resources in conditions of increased workload and minimize the risks of infection spread. The Tomsk Region became one of the first regions of the Russian Federation to organize on its territory a Medical center for remote monitoring of patients with COVID-19 and community–acquired pneumonia (hereinafter referred to as the Center).

Aim: To assess the Center’s activities effectiveness based on the analysis of indicators of the load on the EMT service during the COVID-19 pandemic.

Material and Methods. The Center’s activities effectiveness was assessed based on the analysis of the key parameters of its work, as well as the study of the dynamics of quantitative and time indicators of the load on the EMT service. The information base for the study was the daily operational data of subordinate institutions of the Department of Health of the Tomsk region in the period from 01.06.2020 to 31.12.2021.

Results. The positive dynamics of quantitative and time indicators of the work EMT service after the Center’s work start the confirms effectiveness of remote monitoring of the health status of patients with COVID-19. Reducing the number of calls received by the EMT service, due to the redistribution of the “non-core” load and the routing of patients depending on the reasons for treatment and the severity of the condition, allowed to stabilize the work of the ambulance in a critical situation for the industry.

Conclusion. Taking into account the proven effectiveness, the experience of the Tomsk region in creating a Center that provides remote counseling to patients with COVID-19 can be applied as a measure of adaptation of regional health systems in the event of new epidemic threats.
Associations of health and physical activity selfassessment among the population of a mediumurbanized city of Western Siberia (gender aspect)
Authors: Akimov A. M. , Gafarov V. V. , Bessonova M. I. , Kayumova M. M. , Gakova E. I. , Lebedev E. V. , Akimova E. V.
Published: January 2024

Substantiation of research. Health self-assessment is recognized as a lifestyle indicator that establishes the interpretation of behavioral risk factors and the interest of the population in preventive measures at the population level. The validity of using health self-assessment as a significant indicator of its association with the prevalence of behavioral risk factors for cardiovascular diseases, and particular, with physical activity, is shown both in domestic and foreign scientific literature.

Aim. To determine the associations of parameters of health self-assessment and physical activity of the population of a medium-sized city of Western Siberia in terms of gender differences.

Methods. The analysis is based on the results of studies obtained by extrapolating data from representative samples of the working-age population to the model of the city of Tyumen. The results are based on the analysis of the questionnaire conducted in the framework of cardiological screenings.

Results. It is shown that in a moderately urbanized city of Western Siberia, negative self-assessment of health and complaints about it prevails among women. About 10% of the population of both sexes state sufficient concern for their health. The attitude to physical activity among the working-age population of a medium-urbanized city of Western Siberia is manifested by its low self-esteem with priority among men, and among women by a greater share of lack of leisure in the gender aspect. In the gender aspect, among people who consider themselves healthy, the most negative attitude towards physical activity in terms of positions of a negative attitude towards physical exercise, unsuccessful attempts to do physical exercises, minimal active leisure, low self-esteem of physical activity, as well as its decline over the last year,was established in men. Among people with high self-esteem of health, the prevailing number of men relative to women with a pronounced negative assessment of their physical activity in comparison with other people of their age. Among men, relative to women with low self-esteem of health, the most negative attitude to physical activity was determined in terms of negative attitude to physical exercise, as well as the realization of readiness to perform physical exercises.

Conclusion. Thus, the associative patterns established in the Tyumen population for conventional and non-conventional cardiovascular diseases risk factors represent a scientific basis for some important aspects of regional prevention programs. Such programs should be aimed at the in-depth development of the information block, taking into account medical, social, behavioral and gender differences.
anada’s economic strategy for hydrogen energy development
Authors:   Институт США и Канады им. академика Г.А. Арбатова Российской академии наук (ИСКРАН), Хорошилов Е.Е.
Published: January 2024

В статье рассматриваются цели государственной стратегии Канады в сфере водородной энергетики и особенности канадского подхода к развитию производства, потребления и экспорта «чистого» водорода. Анализируются положения национальной Водородной стратегии для Канады. Исследуется деятельность Канады по созданию водородных альянсов с зарубежными странами, такими как Германия, Нидерланды, Япония, Южная Корея. Делается вывод, что политика Канады в сфере развития водородной энергетики направлена на использование имеющихся у страны преимуществ (существующего технологического задела и инфраструктуры, природных ресурсов) для выхода на лидирующие позиции в мире по производству, использованию и поставкам на внешние рынки «чистого» водорода. При этом национальная водородная стратегия уделяет мало внимания техническим проблемам, связанным с развитием водородной энергетики, и экономической целесообразности производства и использования в канадской экономике «чистого» водорода. Подчеркивается, что на сегодняшний день остаются открытыми вопросы о том, принесут ли осязаемые экономические плоды усилия Оттавы по развитию новых отраслей канадской экономики, в том числе водородной энергетики, и выдержит ли бюджетная система Канады соответствующую дополнительную нагрузку.
Current issues in the methodology of forming an environmental recycling management system for organizations
Authors:   Одинцовский филиал Московского государственного института международных отношений (университета) Министерства иностранных дел Российской Федерации, СТЕПАНОВ А.А. , Бородин Д.В. ,   Государственный университет «Дубна», Курганова И.В. ,   Государственный университет «Дубна»
Published: January 2024

В статье на основе анализа и обобщения современных научных концепций управления устойчивым развитием социально-экологических систем «утилизация - переработка мусорных отходов» раскрыта социально-экономическая сущность экологического рециклинг-менеджмента организаций, его цели, задачи и особенности формирования и применения, предложены концептуальные положения методики разработки модели организации и управления переработкой и утилизацией отходов; раскрыты особенности их разработки по двум основным вариантам -внутреннему и аутсорсингу.
Scientific substantiation of the need to integrate resource-oriented business strategies into the management system of the Russian economy
Authors:   Московский финансово-промышленный университет «Синергия», Фомичев А.Н.
Published: January 2024

Актуальность научной статьи определяется тем, что в последнее время как в научной среде, так и от официальных полномочных представителей государства и бизнеса все чаще звучат постулаты о необходимости и даже неизбежности перехода к ресурсо-ориентированной экономике (от англ. resource based economy). Поскольку эффективное развитие экономических систем принципиально невозможно без адекватного стратегического управления, складывающееся положение дел диктует необходимость оперативной разработки и повсеместного внедрения инновационных видов ресурсных бизнес-стратегий.В данной статье представлены результаты комплексного исследования современных проблемных аспектов становления и развития ресурсо-ориентированной экономики, а также даны инновационные предложения по разработке и внедрению в практику управления бизнесом ресурсных стратегий.
Directions of optimization of companies' strategies taking into account global challenges
Authors:   Московский финансово-промышленный университет «Синергия», Зарецкий Р.О.
Published: January 2024

Цель исследования, проведенного в данной статье, - определить, какие существуют проблемы у современных организаций в связи с большими вызовами и как эти проблемы могут быть решены на стратегическом уровне. Анализируя необходимость изменений стратегии компании в условиях глобальных вызовов, были выявлены стратегические проблемы, а также возможности, на которые компания должна обратить внимание, чтобы оптимизировать свою деятельность посредством стратегического управления. Система контроля оптимизации стратегии компании должна быть основана на сборе и анализе внутренней и внешней информации из среды компании на основе таких источников информации, как учет, анализ процессов и стратегический мониторинг.
Factores de Competitividad en la Industria del Acero en Líderes Mundiales: Una Revisión de la Literatura
Authors: Espinoza Lourdes Fabiola , Gastell-Piloto Loraine , Cruz-Álvarez Jesús Gerardo
Published: January 2024

La competitividad de la industria del acero es uno de los pilares del desarrollo económico y social de un país, ya que su demanda es muy amplia y el impulso de la economía global favorece a las importaciones y exportaciones del mismo. La industria del acero ocupa el segundo lugar, después del petróleo y el gas, con un volumen de producción de acero bruto de 1 689 mil millones de toneladas. Este artículo tiene como objetivo principal identificar cuáles son los factores que impulsan la competitividad en la industria del acero entre los principales líderes a nivel internacional a través de la revisión de diferentes investigaciones recientes sobre el tema.
La selección de proveedores en organizaciones públicas de México ante los desafíos de la era digital
Authors: Ochoa-Medina Ivone Edith , Ruiz-Iduma Sara , Villa-Carbajal María Magdalena
Published: January 2024

Las dependencias gubernamentales en México, deben responder a administrar el ejercicio del presupuesto con base a los lineamientos económicos internacionales, de globalización, racionalización económica, optimización de recursos, transparencia, requiriendo alcanzar niveles de eficiencia, eficacia y efectividad en el ejercicio del gasto público para la prestación y administración de los servicios que le corresponde prestar a la sociedad. La proveeduría de los bienes y servicios representa uno de los procesos claves para la productividad y competitividad, lo cual destaca la importancia contar con herramientas de evaluación y selección de proveedores que eviten en los organismos públicos la implementación de procesos que deriven en corrupción, falta de transparencia y mala administración de la inversión pública. El presente artículo presenta una propuesta de modelo de gestión pública para la selección de proveedores a través de herramientas de análisis de toma de decisión multicriterio, que permite evaluar variables cualitativas y cuantitativas en ambientes de incertidumbre. El modelo se aplicó en el Sector de Educación Medio Superior en el Estado de Sonora. Los resultados obtenidos muestran que este modelo es práctico y factible de implementarse como una herramienta integral para la evaluación y selección de propuestas oferentes para proveer de bienes y servicios públicos.
Determine the exact length of the veneers through programming the condylar inclination of the semi-adjustable articulator
Authors: Del Valle Lovato Juan , Balcazar Jorge
Published: January 2024

Purpose: Various aspects of veneers have been described in literature, such as preparation, material, manufacturing method, bonding technique, remaining dental structure color, among others. The length of veneers incisal edge, that has been determined through photos or videos doing a functional evaluation, creating an anterior guide by mockup in addition to the diagnostic elements mentioned above, the veneers were exactly length based on the condyle inclination.
Materials and methods: The technique shown in the following clinical case report, aims to customize the length of the veneers by programming the condylar inclination and the incisal plate of the semi-adjustable articulator. Results: The veneers made with the present technique was accurately. Conclusion: Customize the length of the veneers demonstrated avoid wear, fracture or breakdown of the bond.