bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAN GENDER SEBAGAI VARIABEL MODERATING PEMBELAJARAN PERBANKAN SYARIAH, LITERASI KEUANGAN SYARIAH DAN RISK TOLERANCE TERHADAP PERILAKU BERINVESTASI DI BANK SYARIAH
Authors: Zulfiana Vina Nafila , Hakim Luqman
Published: January 2022

The movement of sharia investment has experienced a significant increase of sharia investors in East Java at the 3 rank of investor national, however students at the Surabaya University only distribute their funds to Islamic banks to the point or limit of saving accounts. The purpose of this study is to analyze the effect of sharia banking learning, sharia financial literacy, and risk tolerance towards investing behavior with gender as a moderating variable in State University Students in Surabaya. The type of research used is a quantitative research. This research uses 200 respondents with collections technique uses questionnaire and test. Data analysis technique uses Structural Equation Modeling (SEM) with the WarpPLS approach by the WarpPLS 6.0 application. The result shows that Islamic banking learning has no effect, Islamic financial literacy and risk tolerance have a highly significant effect on investment behavior at Islamic banks of State University Students in Surabaya, then gender cannot moderate the learning of Islamic banking on investment behavior but simultaneously gender influences on investment behavior, gender can moderate sharia financial literacy in a weakly significant manner and significantly risk tolerance towards investing behavior in Islamic Banks at State University Students in Surabaya.[Pergerakan investasi syariah mengalami peningkatan signifikan dalam jumlah investor syariah   di Jawa Timur yaitu berada pada urutan ke-3 skala nasional, namun mahasiswa di Perguruan Tinggi Surabaya hanya menyalurkan dananya pada bank Syariah sebatas rekening tabungan saja. Penelitian ini bertujuan untuk manganalisis pengaruh pembelajaran perbankan syariah, literasi keuangan syariah, dan risk tolerance terhadap perilaku berinvestasi dengan gender sebagai variabel moderating pada Mahasiswa Perguruan Tinggi Negeri di Surabaya. Jenis penelitian yang digunakan adalah penelitian kuantitatif. Penelitian ini menggunakan sampel sebanyak 200 responden dengan teknik pengumpulan data berupa kuesioner dan tes. Teknik analisis data menggunakan Pemodelan Persamaan Struktural (SEM) dengan pendekatan WarpPLS berbantuan aplikasi WarpPLS 6.0. Hasil Penelitian menunjukkan bahwa pembelajaran perbankan syariah tidak berpengaruh, literasi keuangan syariah dan risk tolerance berpengaruh highly significant terhadap perilaku berinvestasi di Bank Syariah pada Mahasiswa Perguruan Tinggi Negeri di Surabaya, kemudian gender tidak dapat memoderasi pembelajaran perbankan syariah terhadap perilaku berinvestasi akan tetapi secara simultan Gender berpengaruh terhadap perilaku berinvestasi, gender dapat memoderasi literasi keuangan syariah secara weakly significant dan risk tolerance secara significant terhadap perilaku berinvestasi di Bank Syariah pada Mahasiswa Perguruan Tinggi Negeri di Surabaya.]
Value at Risk with Performing Exponential Generalized Autoregressive Conditional Heteroscedasticity–Generalized Pareto Distribution
Authors: Sinambela Nadiyah Hafidah , Maruddani Di Asih I , Hakim Arief Rachman
Published: January 2022

Stocks are an investment that many investors are interested in but often have a high risk. Value at Risk (VaR) is one tool that is often used in risk measurement. In general, financial data fluctuate rapidly so that the variants of the residuals are not constant or heteroscedasticity. The condition of heteroscedasticity is modeled using the ARCH/GARCH model. If there is an asymmetric effect on the data, it is modeled using an asymmetric GARCH model, namely Exponential GARCH (EGARCH). In addition to the impacts of heteroscedasticity and asymmetric events, extreme events in fat distribution tails are modeled using the Extreme Value Theory method, namely the Peaks Over Threshold method with the Generalized Pareto Distribution (GPD) approach. The data in this study is the return data of PT. Indocement Tunggal Prakarsa Tbk (INTP) for the period of March 1, 2013 - October 31, 2018. It was found that the data was heteroscedasticity, asymmetric, and there were also fat distribution tails, so it was modeled using a combination of EGARCH-GPD models. ARIMA ([2], 0, [2,13]) EGARCH (1,1) has the smallest AIC compared to other models, and then we choose it as the best model. The amount of risk with a 95% confidence level obtained with the GPD approach is 0.333% of current investment.
A C3 Magic Decomposition on Friendship Graph with Odd Order
Authors: Nisa Indah Chairun , Pancahayani Sigit , Soemarsono Annisa Rahmita
Published: January 2022

Let G = (V,E) is graph with a non-empty set V containing vertices and a set of edges E. Also note that if H = {H_i⊆G_i = 1,2,3,...,n} is a collection of subgraphs from G with H_i≅Hj,i ≠ j. If Hi ∩ Hj = ∅ and ⋃n(i-1)Hi = G, then graph G admits a decomposition H. Furthermore, if there are f(v) and g(e) which are vertices and edges labeling at G, the total weight of each subgraph H_i,i = 1,2,3,…,n has the same value, namely ∑_(v∈V(H_i))▒〖f(v)〗+∑_(e∈E(H_i))▒〖g(e)〗= w, then the graph G contains the magic H_i decomposition with w as the magic constant. This research shows that the friendship graph F_n with n = 2k + 1 for k∈N admits a magic -(a,d)-C_3 decomposition with a magic constant w of 29dk + 6a + 15d.
Analysis of Dermatophytosis Therapy at Persian Cat After Using Apple Vinegar (Malus domestica)
Authors: Pratiwi Rina Hidayati , Astiningrum Rania Dwita , Yulistiana Yulistiana
Published: January 2022

Dermatophytosis is a skin disease that mostly infects Persian cats caused by microorganisms, Microsoprum canis. Fungal diseases are often repeated on the surface of the cat's skin and the treatment is still using synthetic chemical-based drugs. Therefore, it is necessary to use a natural antifungal that is economically easy to obtain and can minimize side effects when the cat is undergoing treatment. The purpose of this study was to analyze the response of skin surface in Persian cats (Felis sp.) after using apple cider vinegar. The method used to analyze is a qualitative descriptive method with triangulation techniques. After analyzing the eradication of fungi in 4 samples of Persian cats (Felis sp.) through the use of apple cider vinegar, it was found that the use of apple cider vinegar can eradicate fungi in Persian cats. The cat that had been treated with apple cider vinegar experienced a very good change, where the cat was no longer scratching his body intensely because he felt very itchy caused by the fungus, and his body was clean and had no more fungal crusts. After the fungus is completely removed from the cat's body, the cat's hair will immediately grow by itself. The conclusion is apple cider vinegar can be used for dermatophytosis therapy systemic because it has the ability to inhibit pathogenic fungi activity.
Identification of molecular signatures and pathways of obese breast cancer gene expression data by a machine learning algorithm
Authors: Comertpay Betul , Gov Esra
Published: January 2022

Aim: Currently, the obesity epidemic is one of the biggest problems for human health. Obesity is impacted on survival in patients with breast cancer. However, key biomarkers of obesity-related breast cancer risk are still not well known. Thus, using machine learning to identify the most appropriate features in obesity-associated breast cancer patients may improve the predictive accuracy and interpretability of regression models. Methods: In the present study, we identified 23 differentially expressed genes (DEGs) from the GSE24185 transcriptome dataset. Seed genes were identified from DEGs, the co-expression network genes and hub genes of the protein-protein interaction network. Pathway enrichment analysis was performed for DEGs. The Ridge penalty regression model was executed by using P-values of enriched pathways and seed gene pathway association score to obtain the most relevant molecular signatures. The model was performed using 10-fold cross-validation to fit the penalized models. Results: Angiotensin II receptor type 1 (AGTR1), cyclin D1 (CCND1), glutamate ionotropic receptor AMPA type subunit 2 (GRIA2), interleukin-6 cytokine family signal transducer (IL6ST), matrix metallopeptidase 9 (MMP9), and protein kinase CAMP-dependent type II regulatory subunit beta (PRKAR2B) were considered as candidate molecular signatures of obese patients with breast cancer. In addition, RAF-independent MAPK1/3 activation, collagen degradation, bladder cancer, drug metabolism-cytochrome P450, and signaling by Hedgehog pathways in cancer were primarily associated with obesity-associated breast cancer. Conclusion: These genes may be used for risk analysis of the disease progression of obese patients with breast cancer. Corresponding genes and pathways should be validated via experimental studies.
Analisa produktivitas alat mekanis pada lahan reklamasi di Pit Melati Site Malintut PT Multi Tambangjaya Utama
Authors: Kholik Nur , Saismana Uyu , Novianti Yuniar Siska
Published: January 2022

Pembongkaran dan pemuatan tanah merupakan salah satu kegiatan yang sangat mempengaruhi dalam kegiatan penataan lahan reklamasi. Makin cepat kegiatan pembongkaran dan pemuatan tanah maka kegiatan selanjutnya juga akan semakin cepat. Laju produksi pembongkaran tanah dipengaruhi oleh tingkat produktivitas peralatan mekanis yang digunakan. Semakin besar produktivitas alat tersebut makin cepat sasaran produksi tercapai. Diharapkan pada periode pascatambang, lahan bekas penambangan masih mempunyai kemampuan mendukung usaha pemanfaatan selanjutnya atau setidaknya kondisi tersebut harus dikembalikan mendekati kondisi sebelum dilakukan penambangan.Luas area yang akan dilakukan kegiatan reklamasi yaitu IPD Melati seluas 5,05 hektar dan OPD Melati seluas 1,61 hektar. Volume material soil yang diperlukan yaitu IPD Melati sebanyak 30.300 LCM dan OPD Melati sebanyak 9.660 LCM dengan total 9.660 LCM.Jumlah alat yang tersedia di perusahaan PT Multi Tambangjaya Utama yaitu alat gali muat sebanyak 1 unit dengan tipe Komatsu PC 200 dan alat angkut sebanyak 6 unit dengan tipe Hino 500 FM 260 JD.Hasil produktivitas perjam alat gali muat Komatsu PC 200 setiap hari selama 7 hari didapatkan 54 BCM/jam, 55,29 BCM/jam, 111,86 BCM/jam, 111,07 BCM/jam, 141,98 BCM/jam, 115,24 BCM/jam dan 139,23 BCM/jam.
Pemodelan spasial bahaya dan kerentanan bencana tanah longsor dengan metode AHP berbasis SIG
Authors: Kuncoro Endro , Rismayanti Erviany Indira , Rahman Irfani
Published: January 2022

Kalimantan adalah pulau paling aman, karena aman dari bencana geologi seperti tsunami, gempa dan erupsi gunung berapi. Namun pulau ini tidak dapat dikatakan aman dari gerakan tanah/longsor. Awal tahun 2021, intensitas hujan di Pulau Kalimantan sangat tinggi, sehingga mengakibatkan bencana banjir terbesar dalam 100 tahun terakhir. Tingginya intensitas hujan menyebabkan terjadinya gerakan tanah. Hal ini melatarbelakangi kajian pemodelan bencana gerakan tanah ini. Studi difokuskan di Kecamatan Aranio, dimana terdapat waduk sumber air baku bagi masyarakat di 3 Kabupaten/Kota. Selain itu, waduk ini juga digunakan untuk menggerakkan turbin PLTA Riam Kanan, sehingga bila terjadi gerakan tanah di sekitar Waduk ini, akan berdampak terhadap kehidupan masyarakat dan pasokan listrik. Metode yang digunakan adalah Analytical Hierarchy Process (AHP) berbasis Sistem Informasi Geografis. Parameter yang digunakan yaitu litologi, struktur geologi berupa densitas kelurusan, kemiringan lereng, dan tutupan lahan. Geofaktor kemiringan lereng, litologi dan struktur didapat dari pengolahan Citra DEM dikonfirmasi dengan pemetaan geologi memperhatikan peta geologi regional, sedangkan parameter tutupan lahan diekstrak dari data Satelit Sentinel-1 serta pemetaan foto udara dengan bantuan UAV/drone. Hasil studi ini adalah peta bahaya, kerentanan bencana gerakan tanah yang dapat menjadi pertimbangan dalam penyusunan rencana upaya mitigasi bencana serta penyusunan rencana aksi berkelanjutan di daerah kajian.
Analisis fragmentasi batuan pada kegiatan peledakan di PT Anugerah Bara Kaltim
Authors: Wibowo Heri , Nurhakim Nurhakim , Annisa Annisa
Published: January 2022

Kegiatan penambangan di PT Anugerah Bara Kaltim dilakukan oleh 3 (tiga) kontraktor, yaitu PT Pamapersada Nusantara (PAMA), PT Nusa Persada Indah, dan PT RPP Contractors Indonesia, dimana kegiatan penelitian dilakukan di PT PAMA. Tujuan penelitian ini untuk mengetahui geometri peledakan yang digunakan oleh perusahaan, menganalisis jumlah bahan peledak dan nilai joint plane orientation terhadap fragmentasi hasil peledakan.Peledakan pada PT PAMA menetapkan nilai dari ukuran fragmentasi yang diinginkan harus -100 cm sebesar 80%. Metode yang digunakan untuk menganalisa fragmentasi hasil peledakan dilakukan secara teoritis menggunakan metode Kuz-Ram dengan geometri aktual, hal ini dilakukan guna mengetahui nilai dari persentase fragmentasi.Berdasarkan hasil peledakan yang telah dilakukan telah terjadi ketercapaian fragmentasi di atas 80% untuk ukuran boulder <100 cm dengan jumlah isian bahan peledak per deck 25 kg dengan kedalaman 7,5 m serta nilai joint plane orientation adalah dip out of face dengan nilai powder factor 0,118 kg/m3.
PENGEMBANGAN E-MODUL IPA SMP KELAS VII DENGAN MODEL PROCESS ORIENTED GUIDED INQUIRY LEARNING BERBASIS ISU-ISU SOSIAL SAINS UNTUK MENINGKATKAN KETERAMPILAN BERPIKIR KRITIS SISWA
Authors: Suastrawan Komang Edi , Suardana I Nyoman , Sudiatmika A. A. I. Agung Rai
Published: January 2022

Penelitian ini bertujuan menghasilkan produk e-modul IPA SMP kelas VII dengan model process oriented guided inquiry learning (pogil) berbasis isu-isu sosial sains yang memenuhi kriteria valid, praktis, dan efektif untuk meningkatkan keterampilan berpikir kritis siswa. Jenis penelitian ini adalah penelitian pengembangan dengan mengakomodasi model ADDIE (Analyze, Design, Develop, Implement, and Evaluate). Data pada penelitian ini berupa data kualitatif dan kuantitatif yang dikumpulkan menggunakan angket validitas, kepraktisan, dan tes keterampilan berpikir kritis. Uji efektivitas e-modul menggunakan penelitian pre-experimental dengan one-group pretest-posttest design. Teknik analisis data yang digunakan yaitu teknik analisis deskriptif. Hasil penelitian menunjukkan (1) e-modul disusun dengan model process oriented guided inquiry learning berbasis isu-isu sosial sains kontroversial yang dilengkapi video, audio, dan kuis interaktif. (2) e-modul IPA dinyatakan sangat valid dari segi materi dengan Koefisien Validasi Gregory 1,0, valid dari segi bahasa dengan nilai rata-rata 96,36, dan valid dari segi media dengan nilai rata-rata 96,13. (3) e-modul dinyatakan sangat praktis oleh guru dengan nilai rata-rata 97,56 dan dinyatakan sangat praktis oleh siswa dengan nilai rata-rata sebesar 96,36. (4) e-modul dinyatakan efektif meningkatkan keterampilan berpikir kritis siswa dengan nilai rata-rata posttest sebesar 74,86 kategori baik, serta gain score rata-rata keterampilan berpikir kritis siswa secara keseluruhan yaitu 0,55 dengan kategori sedang. Berdasarkan hasil penelitian, dapat disimpulkan bahwa e-modul IPA berbasis isu-isu sosial sains telah dinyatakan valid, praktis, dan efektif meningkatkan keterampilan berpikir kritis siswa.
Indirect costs associated with "free" paediatric haemodialysis: Experience from Karachi, Pakistan
Authors: Lanewala Ali Asghar Anwar , Shekhani Sualeha Siddiq
Published: January 2022

Treatment of children with end-stage kidney disease (ESKD), requiring maintenance dialysis, poses unique challenges. In low- and middle-income countries, lifelong treatment leads to significant stress on the overall family unit. Families face serious financial, social and psychological consequences despite free treatment. This pilot study, utilising primarily quantitative methods, supplemented by two case studies, is set in Sindh Institute of Urology and Transplantation, a tertiary care hospital in Karachi, Pakistan, providing free medical treatment. Fifty-two caretakers of children receiving haemodialysis for more than five years participated in the quantitative arm. Findings reveal that additional financial challenges may send the entire household into financial catastrophe. Social problems include migration from native cities, impact on the education of the sick child along with changes in lives of siblings. One-third of primary caretakers screened positive for anxiety/depression. Healthcare professionals 'practising' in developing countries face considerable ethical dilemmas in their practice when offering “free” paediatric dialysis services knowing the financial and psychological burden imposed on families.
Improvements on the known quantum speed limits
Authors: Anand Harsh
Published: January 2022

Let us have a Hamiltonian H and 2 states which can time evolve into each other via this Hamiltonian. In this particular situation, say one of the states evolves into the other in time t. Now let us fix these two states ; then we may have infinite Hamiltonians (other than H, and one of them is say H') that can time evolve one of them into the other. But the time taken for this evolution varies from t and is say t' (that is, t' is the time Hamiltonian H' takes to time evolve one of the fixed states into the other). From now on, we shall consider only those Hamiltonians that can time evolve one of the states into the other. The question is given any small positive number a, will there exist a Hamiltonian H such that t' = a? Answer: Yes , the Hamiltonian Ht/a (obtained by rescaling the original Hamiltonian) will work. But, there are bounds that show that as long as the average energy and its fluctuations are bounded (thus, no rescaling allowed), you cannot go arbitrarily fast from one state to another orthogonal state. This discussion falls under the study of quantum speed limits. This document looks into this field of active research. We shall study with care how the question of a speed limit arises: from varying the Hamiltonians between two fixed states ; and hence produce an accurate speed limit between any two fixed states. The process and results shall develop as concretely and smoothly as the problem which is produced.
Copper Oxide/ Functionalized Graphene Hybrid Nanostructures for Room Temperature Gas Sensing Applications
Authors: Gupta Monika , Hawari Huzein Fahmi , Kumar Pradeep , Burhanudin Zainal Arif
Published: January 2022

Oxide semiconductors are conventionally being used as sensing materials in gas sensors, limiting the detection of gases at room temperature (RT). In this work, a hybrid of copper oxide (CuO) with functionalized graphene (rGO) is proposed to achieve gas sensing at RT. The combination of high surface area and presence of many functional groups in CuO/rGO hybrid material makes it highly sensitive for gas absorption and desorption. To prepare the hybrid material, a copper oxide suspension synthesized using copper acetate precursor is added to the graphene oxide solution during its reduction using ascorbic acid. Material properties of CuO/rGO hybrid and its drop-casted thin films are investigated using Raman, FTIR, SEM, TEM, and four-point probe measurement systems. We find that the hybrid material is enriched with oxygen functional groups (OFGs) and defective sites along with electrical conductivity (~1.5 kΩ/□). The fabricated QCM (quartz crystal microbalance) sensor with a thin layer of CuO/rGO hybrid, demonstrates a high sensing response which is twice the response of the rGO-based sensor for CO2 gas at RT. We believe that the CuO/rGO hybrid can be highly suitable for existing and future gas sensors used for domestic and industrial safety.
The Replicability Crisis and the p-Value Debate – what Are the Consequences for the Agricultural and Food Economics Community?
Authors: Heckelei Thomas , Hüttel Silke , Rommel Jens , Odening Martin
Published: January 2022

A vivid debate is ongoing in the scientific community about statistical malpractice and the related publication bias. No general consensus exists on the consequences and this is reflected in heterogeneous rules defined by scientific journals on the use and reporting of statistical inference. This paper aims at discussing how the debate is perceived by the agricultural economics community and implications for our roles as researchers, contributors to the scientific publication process, and teachers. We start by summarizing the current state of the p-value debate and the replication crisis, and commonly applied statistical practices in our community. This is followed by motivation, design, results and discussion of a survey on statistical knowledge and practice among the researchers in the agricultural economics community in Austria, Germany and Switzerland. We conclude that beyond short-term measures like changing rules of reporting in publications, a cultural change regarding empirical scientific practices is needed that stretches across all our roles in the scientific process. Acceptance of scientific work should largely be based on the theoretical and methodological rigor and where the perceived relevance arises from the questions asked, the methodology employed, and the data used but not from the results generated. Revised and clear journal guidelines, the creation of resources for teaching and research, and public recognition of good practice are suggested measures to move forward.
Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts
Authors: Miyazaki Yoshihiro , Mori Nobuhito , Akagi Yuka , Oda Tatsuya , Kida Yasuyuki
Published: January 2022

Cancer-associated fibroblasts (CAFs) in the tumor microenvironment perform glycolysis to produce energy, i.e., ATP. Since the origin of CAFs is unidentified, it is not determined whether the intracellular metabolism transitions from oxidative phosphorylation (OXPHOS) to glycolysis when normal tissue fibroblasts differentiate into CAFs. In this study, we established an experimental system and induced the in vitro differentiation of mesenchymal stem cells (MSCs) to CAFs. Additionally, we performed metabolomic and RNA-sequencing analyses before and after differentiation to investigate changes in the intracellular metabolism. Consequently, we discovered that OXPHOS, which was the primary intracellular metabolism in MSCs, was reprogrammed to glycolysis. In addition, we identified CAF-specific metabolites that were expressed during this reprogramming and determined their presence in the pancreatic tumor tissues of mouse models. Thus, we conclude that normal tissue fibroblasts that differentiate into CAFs undergo a metabolic reprogramming from OXPHOS to glycolysis. Moreover, we identified the CAF-specific metabolites expressed during metabolic reprogramming as potential future biomarkers for pancreatic cancer.
Breast milk as a “programming” factor of child’s health: a study of metabolome, microbiome, and their relationship
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Netrebenko O.K. , Shumilov P.V. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Gribakin S.G. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Published: January 2022

Breast milk is the optimal food product for newborns and infants in the first few months of life. Current advances in nutritional science and new technologies in the field of nutrition give us opportunity to study the features of human breast milk and its advantages over infant formulas. Research studies on human breast milk metabolome (small molecules with the molecular weight <1500 Da) are based on the results of mass spectrometry and nuclear magnetic resonance spectroscopy. Using these methods, small molecules such as acylcarnitines, phospholipids, non-esterified fatty acids, amino acids, and organic acids can be isolated. Due to modern research, it has been possible to establish that human breast milk metabolome is directly related to the health status of pregnant woman. Overweight, obesity and gestational diabetes are the leading factors affecting the metabolome. Key words: breast milk, pregnancy, overweight, obesity, gestational diabetes, metabolome
Cytokine status of neonates born to obese mothers
Authors:   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Novikova V.P. , Petrenko Yu.V. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Ivanov D.O. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Prokopyeva N.E. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Gurina O.P. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Blinov A.E. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Varlamova O.N. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Kosenkova T.V. ,   Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation, Boytsova E.A. ,   Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, Saint Petersburg, Russian Federation
Published: January 2022

Objective. To study the features of the cytokine status of neonates born to obese mothers. Patients and methods. The study included 56 full-term neonates born to mothers with normal body mass index (BMI = 18.5- 24.9 kg/m2) (n = 24) and with obesity (BMI ≥30 kg/m2) (n = 32). Both groups had no gender-related differences; there were 60 and 58% of boys, (p > 0.05), 40 and 42% of girls, respectively, (p > 0.05). Levels of TNF-α, TGF-β, IL-18, IL-13, IL-10, and IFN-γ in umbilical cord blood were determined by a quantitative enzyme-linked immunosorbent assay (ELISA). Results. Compared with children born to mothers with normal BMI, children born to obese mothers had increased levels of TNF-α (4.94 ± 3.55 (n = 24) and 12.75 ± 10.80 (n = 32) pg/mL, respectively) and IFN-γ (7098.14 (n = 24) and 25536.38 ± 9541.82 (n = 32) pg/mL, respectively) in umbilical cord blood serum. Conclusion. Maternal overweight and obesity are associated with increased levels of TNF-α and IFN-γ in umbilical cord blood serum in children, which confirms previous observations of immune dysregulation in offspring of obese mothers, providing a potential link with increased incidence of chronic inflammatory diseases and obesity in children. The mechanisms of this effect require further investigation. Key words: maternal obesity, cytokine status, umbilical cord blood, neonates, TNF-α, TGF-β, IL-18, IL-13, IL-10, IFN-γ
Medullary nephrocalcinosis in children with Williams syndrome: diagnosis, treatment, and prevention of complications
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Filippova T.V. , Litvinova M.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   A.S.Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department, Moscow, Russian Federation, Nuralieva S.Z. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Khavkin A.I. ,   Academician Yu.E.Veltishchev Research and Clinical Institute for Pediatrics, Pirogov Russian National Research Medical University, Moscow, Russian Federation, Shumikhina M.V. ,   N.F.Filatov Children’s City Hospital, Moscow Healthcare Department, Moscow, Russian Federation
Published: January 2022

The article presents a clinical case of the development of medullary nephrocalcinosis in the patient with Williams syndrome. First manifestations of nephrocalcinosis in the patient were detected during the first year of life and preserved until 8 years of age. According to the world literature, the development of hypercalcemia can occur in 40% of patients with Williams syndrome, 5% of patients develop nephrocalcinosis with further progression of renal dysfunction and development of kidney stone disease. The presented case demonstrates the necessity of differential diagnosis of nephrocalcinosis with inclusion of Williams syndrome into the list of diagnoses under consideration, as well as the problem of managing children with Williams syndrome, considering the possibility of the nephropathy development. A comprehensive approach to the management of patients with Williams syndrome should also include monitoring by a nephrologist. Such approach will enable timely prevention and avoid serious kidney complications in patients with Williams syndrome. Key words: Williams syndrome, hypercalcemia, hypercalciuria, nephrocalcinosis, kidney stone disease
ANALISIS KESALAHAN BAHASA PADA TEKS CERAMAH SISWA SEKOLAH MENENGAH KEJURUAN
Authors: Stevania Arinta Ayu , Wardani Nugraheni Eko , Andayani Andayani
Published: January 2022

This research aims to describe: (1) a variety of a language error in Indonesia text lectures students (2) the factors cause the occurrence of an error in the text of the lecture, and (3) efforts that can be made to address errors in the text of the lecture Indonesia students of class XI SMK Murni 1 Surakarta 2018/2019 school year. This type of research is qualitative research. The technique of sampling with purposive sampling and in-dept interview Researchers using interactive analysis techniques, with the primary data source text lectures students of class XI SMK Murni 1. Theory triangulation technique is used as a test of the validity of the data. The results of the analysis of the findings of language errors in the text of the lecture differentiated by linguistic taxonomy can be explained as follows. First, the language errors are found in the text of the lecture students of class XI can be divided into four, namely the fault of 4.58% morphology, 5.15% of semantics, 6.10% of syntax and spelling of 84.35%. Second, the error-speaking students due to several factors, including: (a) unfamiliarity and lack of carelessness students in writing a text, (b) the limited sources of student learning, and (c) the lack of sensitivity of the student on the development of the language. Third, efforts to minimize the mistakes that language can do, including: (a) assessment of the student's writing, (b) add the learning resources, and (c) literacy and writing exercise for students.
ANALISIS KESALAHAN BERBAHASA PADA SOAL UJIAN PELAJARAN BAHASA INDONESIA DI SMA
Authors: Wardani Shinta , Setiawan Budhi , Hastuti Sri
Published: January 2022

This research aims to describe and explain: (1) the kinds of mistakes-speaking on the matter, (2) the cause of the error on the question of language, (3) communication effects caused due to an error on a question of language Final Assessment  subjects Indonesian Language grade XI public senior high school in Sukoharjo Area school, (4) understanding teacher against the rule drafting problem , and (5) precision drafting problem Final Assessment subjects Indonesian Language grade XI public senior high school in Sukoharjo  based on rules of preparation of a matter. This type of research is qualitative research. Qualitative research this time is both a content analysis (content analysis) with the main data source about the Final Assessment of the Odd Semester subjects Indonesian Language grade XI public senior high school in Sukoharjo . The technique of sampling with purposive sampling and snowball sampling. This research uses data sources triangulation and triangulation method as a test of the validity of the data. The results of the analysis of the findings can be explained as follows. First, errors in language reserved assessment of the end of the Semester in the form of spelling errors, Word, and sentence. Second, language mistakes caused by internal factors and external factors. Internal factors in the form of less understand linguistic rules, the lack of rigour in drawing up the question, a habit of relying on a team of editing, and the wrong habits. While external factors in the form of the mistakes of other languages, is vulnerable for a short time, and there is no evaluation. Third, the effect of communication language errors are significant because the learners feel difficulty in understanding the intent of the question. Fourth, teachers less understand rule drafting reserved either in theory or practice. Fifth, the question of the drafting of the Rules contained in the matter of the assessment of the finalsemester subjects Indonesian Language grade XI public senior high school in Sukoharjo  is not fully using the rules of preparation of the matter that is being applies both from the aspect of material and construction aspects.
NOVEL AMERICAN WIFE SITTENFELDKARYA ELIZABETH CURTIS : PENGARUH LAKI-LAKI TERHADAP PEREMPUAN
Authors: Supriyono Supriyono
Published: January 2022

The male hegemony in Elizabeth Curtis Sittenfeld's novel American Wife presents women with their dominance. This shows an ambiguous attitude of a woman in responding to the discourse of male domination, the injustice of women's roles and an affirmation of women's resistance to male domination. From here the main problem is the subject's response to the discourse of male domination through women's resistance strategies through participation in society. The concept or theory and the research method used are qualitative. The result obtained is that the idea of equality in education is used as a strategy of resistance in the discourse of male domination as well as strengthening women's resistance to male domination. In addition, the strategy also develops ideas about women's strength based on equality in education, namely through access to higher education.
PENINGKATAN KOMPETENSI MENGEMBANGKAN TES BERPERSPEKTIF HIGHER ORDER OF THINKING SKILLS (HOTS) PADA GURU BAHASA INDONESIA SMP
Authors: Suwandi Sarwiji , Sudaryanto Memet , Wardani Nugraheni Eko , Zuliyanto Sugit , Ulya Chafit , Setiyoningsih Titi
Published: January 2022

Pembelajaran Bahasa Indonesia berorientasi pada keterampilan berpikir tingkat tinggi atau Higher Order Thinking Skill (HOTS). Namun demikian, berdasarkan observasi terbatas teridentifikasi soal-soal buatan guru belum sepenuhnya berorientasi pada pengembangan keterampilan berpikir tingkat tinggi. Penelitian ini merupakan penelitian deskriptif kualitatif dengan pendekatan studi kasus. Sumber data meliputi guru-guru Bahasa Indonesia di SMPN 4 Surakarta dan tugas tertulis. Teknik pengumpulan data dengan wawancara terstruktur dan tidak terstruktur serta analisis dokumen. Teknik validitas data melalui triangulasi metode dengan cara mencocokkan data antara wawancara dan hasil tes tertulis. Teknik analisis data dengan analisis model interaktif. Setelah dilakukan tindakan perbaikan (treatment) kemampuan guru dalam mengembangkan soal bahasa Indonesia mengalami perubahan terutama dalam menentukan kata kerja operasional yang dibutuhkan terukur sesuai dengan dimensi tesnya. Ide pengembangan instrumen tes yang dikembangkan oleh guru bisa bercabang dan divergen sesuai dengan tujuan tes yang hendak dicapai. Hal ini menunjukkan bahwa upaya tindakan perbaikan (treatment) dapat meningkatkan kemampuan guru Bahasa Indonesia dalam menyusun soal berprespektif HOTS. Indikator menunjukkan kemampuan terukur sebagai alat untuk mencapai tujuan. Pengguna potensial hasil penelitian ini adalah sekolah dan Dinas Pendidikan Kota Surakarta dalam mengembangkan kompetensi profesional pendidik.
ANALYSIS OF REGULATORY FRAMEWORK OF MEDICAL AND SOCIAL EXPERTISE FACILITIES DURING THE PANDEMIC (COVID-19)
Authors:   Main Bureau of Medical and Social Expertise of the Republic of Bashkortostan of the Ministry of Health of the Russian Federation, Ufa, Russia, Safronova E.V. , Mukhanova I.F. ,   Bashkir State Medical University of the Ministry of Health of the Russian Federation, Ufa, Russia, Bilalov F.S. ,   Bashkir State Medical University of the Ministry of Health of the Russian Federation, Ufa, Russia, Sharafutdinov M.A. ,   Bashkir State Medical University of the Ministry of Health of the Russian Federation, Ufa, Russia
Published: January 2022

The article analyzes regulatory framework governing performance of medical and social expertise (MSE) facilities in the Republic of Bashkortostan. The paper uses methods of copying information from primary and reporting medical documents and logical analysis of regulatory documents. In the conditions of the COVID-19 pandemic, activities of MSE facilities are guided by the Temporal procedure for examination. The Procedure guides establishment of disability, development of rehabilitation or habilitation programs for the disabled (disabled children), as well as determination of the degree of loss of professional ability to work as a result of industrial accidents and occupational diseases, and development of rehabilitation programs for victims of industrial accidents and patients with occupational diseases. The examination is carried out in absentia, without presence in person. Also, the Order of the Ministry of Labor of the Russian Federation No. 979n dated 12/30/2020 approved the "Procedure for organization and performance of federal institutions of medical and social expertise", stipulating the rules, sequence and timing of the provision of MSE services to the citizens. The Order of the Ministry of Labor of the Russian Federation No. 106n dated 05.03.2021 approved the "List of indications and contraindications for providing the disabled people with technical means of rehabilitation", which has introduced a number of changes to the technical means of rehabilitation of the disabled people. The main feature of the MSE procedure was the automatic extension of disability for 6 months if there is no referral for examination (form 088/y) from a health care facility. In the framework of the Temporal Procedure, disability was automatically extended for 29,624 citizens in 2020 (38.0% of the total number of examinations), and 31442 citizens for the six months of 2021 – (70.0% of the total number of examinations). Further improvement of the legislative complex during the taugh epidemiological situation becomes an essential element of the legal regulatory process in order to restore social justice for the most socially vulnerable segments of the population in urgent need of the state legal protection under the current difficult circumstances.
Green and Resilient Mixed Supply Chain Network Design to Reduce Environmental Impacts and Deal With Disruptions
Authors: Vali-Siar Mohammad Mahdi , Roghanian Emad
Published: January 2022

Disruption risks may halt or adversely affect supply chain operations and can lead to deviations in its objectives. One of the most important objectives of the supply chain which can be adversely affected by disruptions, is environmental objective. Therefore, considering supply chain resilience and environmental aspects simultaneously is of great importance. In this paper, the problem of designing a green and resilient mixed open and closed-loop supply chain network under operational and disruption risks has been studied. A bi-objective mixed integer linear programming model is proposed to formulate the problem. Some resilience strategies are applied to deal with disruption risks and enhance supply chain resilience. In order to overcome the complexity of the problem and solve the problems with medium and large sizes, a new meta-heuristic algorithm called multi-objective hybrid Ant-colony optimization and teaching and learning based optimization (ACO-TLBO) has been proposed and compared with two hybrid metaheuristics and the augmented ε-constraint method through various test problems. The outcomes showed that the ACO-TLBO algorithm is very efficient in obtaining high-quality Pareto solutions and is the best method among the proposed methods. Also, in order to show the applicability of the problem and validate the model and solution methods, a real case study in the tire industry has been presented and analyzed. The results of analyses demonstrate the high effectiveness of resilience strategies and the necessity of joint consideration of resilience and greenness in the supply chain design.
Trends and Effect of Marginalization on Diabetes Mellitus-Related Mortality in Mexico, 1990-2019
Authors: Gutiérrez-León Eduardo , Escamilla-Santiago Ricardo Antonio , Martínez-Amezcua Pablo , Bilal Usama , Lazo Mariana , Ogaz-González Rafael , López-Cervantes Malaquías
Published: January 2022

Globally, diabetes mellitus (DM) is one of the leading causes of mortality. However, this behavior may differ over time for countries given their intrinsic factors. The objective of the study is to characterize the trend and assess the potential effect of marginalization on DM mortality during 1990-2019 in Mexico. We analyzed death certificates where DM was listed as the underlying cause of death (N=1,907,173) and the extent to which DM mortality changes, were associated with marginalization from an age-period-cohort analysis. DM mortality has increased for Mexico in the 1990-2019 period, this change was faster in the first half of our study and slowed after 2004. The highest marginalization quintiles drove the changes in DM mortality trends during 1990-2019 in Mexico, with higher risk of dying in these quintiles with aging than the lowest. In the most recent cohorts, the highest marginalization quintiles showed twice the risk of dying from DM than the lowest. Renal complications were the leading cause of death in persons with DM during 1990-2019, with a marked increase since 1999-2001. In conclusion, Mexico continues with a very high DM mortality, but this has slowed over time, and subnational differences in the marginalization can partially explain this trend.
Coupled Modes Enhance Random Lasing in Plasmonic Thin Etalons
Authors: Haddawi S. F. , Roostaei N. , Hamidi S. M.
Published: January 2022

In this work, we experimentally and theoretically proved a flexible fine random laser from a two-face etalon plasmonic structure based on PDMS. Accordingly, PDMS was fabricated using the nanoimprint lithography method and coated by a thin gold layer with a thickness of 35 nm using a PVD device and light-emitting polymer (F8PT) to enhance the scattering and efficiency of the random laser. Using a plasmonic gold grating as a substrate, the simulation results compared the upside and downside of the plasmonic etalon structure. Moreover, an enhancement was observed in light transmission, and it is common to predict high efficiency in random lasing properties. The experimental results showed a comparison between normal plasmonic etalon samples and symmetric and asymmetric etalon-based nanostructures with thicknesses of 200, 400 and 600 \(\mu m\) and reported that random lasing properties had better results for samples with thinner spaces based on coupled mode effects. Correspondingly, this was done by increasing the intensity and decreasing the lasing threshold from 22 𝜇J in normal etalon to 16\(\mu J\) in the thinnest etalon structure.
Dynamic Changes of Peripheral Blood Markers Predict Prognosis of Patients with Advanced Non-Small Cell Lung Cancer Receiving Anti-PD-1/PD-L1 Treatment
Authors: Tang Gaoyan , Liu Yan , Zhang Qingyun , Yang Baohong , Ding Yanhong , Yu Guohua
Published: January 2022

Background Immune checkpoint inhibitors have been routinely used in the treatment of advanced non- small-cell lung cancer (aNSCLC) with significantly improved survival rate. However, the identification of reliable prognositic and predictive biomarkers is lacking. The aim of the study was to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and their dynamic changes for aNSCLC. Methods We retrospectively analyzed 60 patients with aNSCLC who received immunotherapy. The NLR and PLR were assessed at baseline (NLR0 and PLR0) and after 4 cycles of treatment (NLR4c and PLR4c). Results Of all aNSCLC patients on immunotherapy, 47 (78.3%) cases were in the response group. Whether at baseline or after 4 cycles of treatment, the levels of NLR and PLR in the response group were both significantly lower than those in the non-response group (p < 0.05). Patients with a high NLR4c had poor progression-free survival (PFS) and overall survival (OS) independently in multivariate analysis (3.90 vs. 7.50 months, p = 0.005; 7.20 vs. 15.90 months, p = 0.041, respectively). Patients with high NLR0-highNLR4c were associated with poor PFS and OS (p = 0.009, p = 0.001 respectively). Results are similar for PLR. Conclutions NLR after 4 cycles of treatment and dynamic changes of NLR and PLR during immunotherapy might help to predict a more accurate prognosis in aNSCLC patients.
Ceramic Workers and the Inflammatory Effects of the Silica Dust on the Nasal Mucosa Detected by Nasal Cytology: a Pilot Study
Authors: Begvarfaj Elona , Greco Emilio , Caruso Arturo Armone , Masieri Simonetta , Velardita Carmelita , Cavaliere Carlo
Published: January 2022

Background. Adverse health effects due to occupational exposures are a global public health concern and have been studied for many years. Ceramic workers are occupationally exposed to a wide range of toxic substances as they manage clay (silico-aluminous feldspar mixed with sodium, potassium salts and iron oxide). The objective of this study was to assess the presence of any inflammation or alteration of the nasal mucosa of ceramic workers by nasal cytology.Materials and methods. Ceramic workers from Caltagirone (Italy) were enrolled. Nasal symptoms, atopy, health habits and workplace features were assessed by a special questionnaire, and nasal mucosa health was evaluated by nasal cytology.Results. The cytological study of the nasal mucosa showed the constant presence of abundant, thick and filamentous mucus, as well as a reorganization of the nasal cellularity with a prevalence of muciparous metaplasia and almost total absence of hair cells, for almost all of the subjects.Conclusions. A significant proportion of ceramic workers showed chronic inflammatory rhinitis on nasal cytology, with a remodelling of the nasal mucosa and thick mucus. Nasal cytology may be a helpful tool for the screening of any pathology of the upper airways.
On Kinetic and Irreversible Thermodynamic Treatments of a Rarefied Gaseous Plasma Bounded by a Moving Plate.
Authors: Wahid Taha Zakaraia Abdel , Shahein Rabab
Published: January 2022

The peculiarities of the Rayleigh problem (RP) governing equations of a rarefied gaseous plasma (RGP) are analyzed. They were proven to conform to the entropic performance for the RGP system using the moment method, separation of variables, associated with traveling-wave techniques in irreversible thermodynamics (IT) approach. Maxwell’s equations and the Boltzmann equation (BE) of the Bhatnagar- Gross- Krook (BGK) type were solved. The BE considerable advantage is that it allows us to analyze the depth performance of the equilibrium electrons' velocity distribution function (EVDF) and the perturbed EVDF and their implementation to determine how far the system is from the equilibrium state (ES). As a result, the contrast between the equilibrium EVDF and the perturbed EVDF was conceptually elucidated at various periods. This significant benefit enables us to consider our model's non-equilibrium IT properties. For this purpose, the derived EVDF should be employed in entropy, production, and other critical thermodynamic variables. After analyzing the results, we discovered that H-theorem, thermodynamic principles, and Le Chatelier’s law were consistent with our model. The Gibbs rule was used to express how the various influences of the forces acting on the system's internal energy modification (IEM) are expressed. The findings showed that the proposed model could accurately capture the performance. The suggested type could accurately predict RGP helium and argon gases performance in the upper atmosphere's ionized belts. 3D-Graphics representing the physical parameters were generated using analysis of variance calculations, and the results are thoroughly presented. The importance of this research stemmed from its broad array of utilization in micro-electro-mechanical systems (MEMS), physics, electrical engineering, and nano-electro-mechanical systems (NEMS) technologies in a variety of commercial and industrial utilization.