bluuebunny/crossref_metadata_2025 huggingface dataset:
Russian Philosophers on the Concept of a Scientific Worldview
Authors: Aleksandrov V. B.
Published: April 2023

The article shows the controversiality of the concept of “scientific worldview.” It indicates its connection with the ideology of Marxism, which claimed to reflect the objective laws of social development. The idea is made that within the framework of this approach, the understanding of the worldview as a source of personal meanings gives way to its vision as a combination of principles of socially significant activity. This approach is opposed to the position of Russian philosophers who criticized the concept of a scientific worldview and pointed out that the source of personal meanings that make up the content of the worldview is the life experience of the subject, understood as irrational introduction to being. To express such an introduction to being, the concepts of “world sense” and “world consciousness” used by Berdyaev can be used. Conceptual, scientific worldview means the attitude to reality as something external, otherworldly, i. e. is the position of substance. Science, according to Berdyaev, is knowledge of necessity through adaptation to world given and knowledge of necessity. To fill the meaning of the inner life of a person, a specific being of a person plays a decisive role, which acts as a form of rooting in being as such. In other words, a person acquires the main meanings of his existence not on the basis of a worldview, the content of which is a generalized image of the outside world, they are acquired from his own experience of spiritual growth, which constitutes the essential basis of life.
Interaction of the local governments with the city community of Khabarovsk: sociological analysis
Authors:   The Russian Presidential Academy of National Economy  and  Public  Administration, the Far-Eastern  institute of management – branch  of  RANEPA, Bulanova M.A.
Published: April 2023

Sociological analysis of interaction of the local governments with the population of Khabarovsk, presented as the local community is given in this article. Based on the forms of participation of the population determined by the current legislation, evaluation of their relevance in solving the problems of local importance and urgent problems of life was given. From the methodological standpoint of sociology, the author interpreted the results of public opinion polls of the citizens as the forms of their collective behavior and involvement in the socially useful activities in the territory of their residence, in public hearings, and participation in the municipal elections.As a result of research, it was determined that the activity of the participation of the population of Khabarovsk in the legally determined forms of interaction with the local self-government is extremely low due to the weakness of solidarity social ties, high disunity of power and civil society. This is due to both the objective conditions for localizing residents in city apartments of apartment buildings and their subjective assessments of dissatisfaction with the activities of local governments to solve the urgent problems of their life and unwillingness to contribute to their solution. To increase the civic activity of population, it is advisable to develop the network interaction with the local government on the basis of modern means of communication, aimed at formation of the solidarity local communities in the territories of residence, to stimulate them with grant support from the city budget.
Prácticas educativas y resistencias. Transiciones políticas de adolescentes y jóvenes de Pereira
Authors: Farfán Orozco Martha Beatriz , Bedoya Hernández Erika María
Published: April 2023

Las resistencias y las prácticas educativas se ubican en las construcciones políticas y sociales de adolescentes y jóvenes en la ciudad de Pereira, las cuales se encuadran en las vivencias cotidianas, espacios comunitarios y educativos: apostándole a proce-sos formativos institucionales y no institucionales que fortalecen y resignifican expe-riencias a través de las interacciones donde transitan la subjetividad para constituirse como sujetos ético-políticos.El resultado de esta reflexión convoca a pensar las prácticas educativas y de resis-tencias de los adolescentes y jóvenes desde las pedagogías liberadoras, concibiendo entonces un sujeto biográfico que se plantea la posibilidad de la autointerpretación de las experiencias personales y colectivas desde su contexto, realidad y cotidianidad, es decir, se convierte no solo en la voz personal, sino en la voz de otros; lo que permite ubicar las prácticas de resistencia como esos puntos de tensión en el marco de las re-laciones de poder, que evidencia la construcción subjetiva en las prácticas formativas desbordando la concepción de educación institucionalizada, además, de tensionar las guías de aprendizaje instituidas o implantadas para promover la construcción de prác-ticas educativas participativas. De esta manera, los adolescentes y jóvenes pueden transitar de escenarios violentos, conflictivos y tensionados a escenarios participati-vos, plurales, diversos, artísticos, entre otros.
Regulating preventive measures in addressing socioeconomic determinants of crime: Sociolegal and economic considerations
Authors: Enggarsasi Umi , Sa’diyah Nur Khalimatus
Published: April 2023

The COVID-19 pandemic has had a negative impact on the health and economy of people around the world. In addition, lack of access to income and social restrictions have increased the crime rate related to COVID-19. In this context, this study seeks to investigate the effect of the pandemic, especially social restrictions on the increase in crime. Furthermore, this study aims to formulate policies that are interrelated between socioeconomic pressures during a pandemic and crime. This study is formulated based on the theory of socioeconomic determinants of crime from Buonanno (2003), while the theorization of the relationship between pressure as the effect of pandemics and its use as crime legitimacy is adopted from Agnew (2006) and Green (2020). However, the focus and formulation of the socioeconomic determinants of crime, especially during the COVID-19 period, have rarely been examined in previous studies. To fill this void, this research was conducted using a normative-empirical approach in a qualitative design. The results show that COVID-19 has influenced the pattern of crime in society. In this context, clearer governance is needed to modify the negative effects of the pandemic which is adjusted to each of the socioeconomic determinant. Furthermore, regulations and targeted frameworks need to be integrated into areas related to business, tourism, and industry to absorb labor and minimize unemployment.
Autoreactive IgE: pathogenic role and therapeutic target in autoimmune diseases
Authors: CHARLES Nicolas , Krohn Inge Kortekaas , Kocatürk Emek , Scheffel Jörg , Altrichter Sabine , Steinert Carolin , Xiang Yi-Kui , Gutermuth Jan , Reber Laurent , Maurer Marcus
Published: April 2023

Autoimmunity is the break of tolerance to self-antigens that leads to
organ-specific or systemic diseases characterized by the presence of
pathogenic autoreactive antibodies (AAb) produced by plasmablast and/or
plasma cells. AAb are prevalent in the general population and not
systematically associated with clinical symptoms. In contrast, in some
individuals, these AAb are pathogenic and drive the development of signs
and symptoms of antibody-mediated autoimmune diseases (AbAID). AAb
production, isotype profiles, and glycosylations are promoted by
pro-inflammatory triggers linked to genetic, environmental, and hormonal
parameters. Recent evidence supports a role for pathogenic AAb of the
IgE isotype in a number of AbAID. Autoreactive IgE can drive the
activation of mast cells, basophils and other types of FcεRI-bearing
cells and may play a role in promoting autoantibody production and other
pro-inflammatory pathways. In this review, we discuss the current
knowledge on the pathogenicity of autoreactive IgE in AbAID and their
status as therapeutic targets. We also highlight unresolved issues
including the need for assays that reproducibly quantify IgE AAbs, to
validate their diagnostic and prognostic value, and to further study
their pathophysiological contributions to AbAID.
Unusual Response to Magnet application: What is the Mechanism?
Authors: Ghosh Anindya , Sriram Chenni S. , Pandurangi Ulhas M.
Published: April 2023

An asymptomatic 48-year-old gentleman presented for routine
interrogation of his Medtronic dual chamber transvenous pacemaker. The
device was implanted 4 years ago for post-operative intermittent high
grade atrio-ventricular block following mechanical aortic valve
replacement. As per our protocol, we performed a 12-lead
electrocardiogram with and without magnet application. The unusual
response elicited after application of magnet is mechanistically
explained.
Morphine dependency impairs neural connectivity between the anterior cingulate and orbitofrontal cortices during endeavor-based decision-making
Authors: Fatahi Zahra , Zibaii Mohammad , Ghorbani Ahmad , Alizamini Mirmohammadali , Haghparast Abbas
Published: April 2023

Abstract Cost-benefit decision-making is a procedure by which an
organism chooses among different choices when each choice indicates an
operation linked to a different outcome. In addition, there is
considerable evidence showing that opiates affect several aspects of
cognition, including cost-benefit decisions. In the present study, we
evaluated functional and neural synchronization between the
orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) while
value-based decision-making in pre-morphine dependency and morphine
dependency times in rats. A T-maze decision making task with a
differential expense (high vs. low endeavor) and remuneration (high vs.
low remuneration) was performed and local field potentials (LFP) from
the OFC and ACC were recorded simultaneously. Results demonstrated that
neural simultaneity was seen in theta and low beta frequencies between
both regions, when the animals chose high endeavor/high remuneration.
However, while the rats preferred low endeavor/low remuneration in
pre-morphine dependency time and morphine dependency time, neural
synchronization was insignificant. The obtained findings clarified that
functional connection and neural simultaneity between the ACC and OFC in
theta and low beta frequencies has an essential role in endeavor-based
decision-making, and disturbance of make a decision in morphine-treated
animals is associated with changes in this frequency range in the OFC
and ACC.
Ancient DNA is preserved in fish fossils from tropical lake sediments
Authors: Muschick Moritz , Jemmi Eliane , Lengacher Nicholas , Hänsch Stephanie , Wales Nathan , Kishe Mary , Mwaiko Salome , Dieleman Jorunn , Lever Mark , Salzburger Walter , Verschuren Dirk , Seehausen Ole
Published: April 2023

Tropical freshwater lakes are well-known for their high biodiversity,
and the East African Great Lakes in particular are renowned for their
endemic cichlid fish adaptive radiations. While comparative phylogenetic
analyses of extant species flocks have revealed patterns and processes
of their diversification, evolutionary trajectories within lineages,
impacts of environmental drivers, or the scope and nature of now-extinct
diversity remain largely unknown. Time-structured paleodata from
geologically young fossil records, such as fossil counts and
particularly ancient DNA data, would help fill this large knowledge gap.
High ambient temperatures can be detrimental to the preservation of DNA,
but refined methodology now allows data generation even from very poorly
preserved samples. Here, we show for the first time that fish fossils
from tropical lake sediments yield endogenous ancient DNA (aDNA).
Despite generally low endogenous content and high sample drop-out,
high-throughput sequencing and in some cases sequence capture allowed
for taxonomic assignment to family or tribe level and phylogenetic
placement of individuals. Even skeletal remains weighing less than 1 mg
and up to 2700 years of age could be phylogenetically placed. We find
that the relationship of degradation of aDNA with the thermal age of
samples is similar to that described for terrestrial samples from cold
environments adjusted for elevated temperatures. Success rates and aDNA
preservation differed between the investigated lakes Chala, Kivu and
Victoria, possibly caused by differences in water oxygenation at
deposition. Our study demonstrates that sediments of tropical lakes
preserve genetic information on rapidly diversifying taxa over time
scales of millennia.
10-year follow-up report and neurologic sequelae in a case of neonatal severe primary hyperparathyroidism
Authors: Khosroshahi Nahid , Haghshenas Zahra , Afrooghe Arya , Ahmadi Elham , Torshizi Mahdieh Mousavi
Published: April 2023

We present a 10-year follow-up and describe our experience in managing a
case of neonatal severe primary hyperparathyroidism (NSHPT) for the
first time in Iran. Microcephaly, mental retardation and epilepsy may be
long time sequels of NSHPT and the brain MRI findings are compatible
with old hypoxic-ischemic event.
Development of a novel microplate for high-throughput screening and optimization of DHA producing strains based on CFD technology
Authors: Shaojie He , Yang Linhui , Du YuanHang , Tong LingLing , Wang Yue , dongsheng Guo
Published: April 2023

Microtiter plates are suitable for screening and process development of
most microorganisms. They are currently the container of choice for
high-throughput and small-scale microbial culture, but require
optimization for specific work. This research presents a novel type of
microtiter plate was developed using computational fluid dynamics (CFD)
technology. The new plate provides high oxygen supply and optimal mixing
effects for the fermentation culture of docosahexaenoic acid (DHA)
producing strains, surpassing the conventional method of strains
screening with shake flasks, which is insufficient. the shape of the
microtiter plate was modified, and baffles were introduced to improve
mass transfer and oxygen supply effects in the vibrating bioreactor. CFD
technology was used to model the new plate’s characteristics,
establishing the superiority of hexagonal microtiter plates with six
baffles. Parameters in the incubation process, such as vibration
frequency and liquid load, were optimized, and the final result achieved
a KLa of 0.61s-1 and a volume power input of 2364 w/m3, which was 4-5
times better than the original 96-well plate. The culture results
optimized by the model were also verified. Therefore, this new
microtiter plate provides a powerful tool for future high-throughput
screening of strains.
Overview of Well-Established c-Si-Based Solar Cell Concepts
Authors: Hagendorf Christian , Cura Carlos , Clausing Roland , Lange Stefan , Adner David , Großer Stephan , Turek Marko
Published: April 2023

A unified schematic visualization of Si solar cell technologies as well
as tandem interconnection schemes (2, 3, 4 terminal) with industrial
relevance is presented based on a comprehensive literature review.
O lago não é tão raso quanto parece
Authors: Oliveira Genario , Noblat Glaucia
Published: April 2023

Nos últimos dois anos o mundo vivenciou uma crise sanitária com a pandemia do coronavírus 19 (COVID-19). O crescimento exponencial de casos novos da doença no globo e o aumento da morbidade e mortalidade levou a busca incessante por novas terapias que pudessem aumentar as curvas de cura da infecção. As vacinas e terapias de suporte ainda fazem parte do escopo de inúmeras Farmacêuticas que investem em pesquisa clínica para obtenção de melhores resultados.
O SARS-CoV-2, vírus causador da doença COVID-19, pode resultar em sintomas respiratórios rápidos e intensos, insuficiência pulmonar e até o óbito. Dos sintomas que podem ser apresentados é reportadona literatura febre, tosse, mialgia ou fadiga, seguidos por pneumonia e dispneia. Sintomas relatados menos comuns incluem: dor de cabeça, diarreia e hemoptise.
Differential associations of glutamic acid decarboxylase antibodies (GADA) and C-peptide with insulin initiation, glycemic responses and severe hypoglycemia in patients diagnosed with type 2 diabetes
Authors: Fan Baoqi , K.P. Lim Cadmon , W.M. Poon Emily , S.H. Lau Eric , Wu Hongjiang , Yang Aimin , Shi Mai , H.T. Tam Claudia , Y.S. Wong Samuel , Kam-Pui Lee Eric , H.T. Wang Maggie , H.S. Chu Natural , Ozaki Risa , P.S. Kong Alice , Chow Elaine , C.W. Ma Ronald , O.Y. Luk Andrea , C.N. Chan Juliana
Published: April 2023

  

Objective

We examined the associations of glutamic acid decarboxylase antibodies (GADA) and C-peptide (CP) with insulin initiation, glycemic responses and severe hypoglycemia in type 2 diabetes (T2D).

Research Design and Methods

In 5230 Chinese patients with T2D (mean±SD age: 56.5±13.9 years, diabetes duration (median, IQR): 6 (1-12) years, 47.6% men) enrolled consecutively in 1996-2012 and prospectively observed till 2019, we retrospectively measured fasting CP and GADA in stored serum and examined their associations with aforementioned outcomes.

Results

At baseline, 28.6% had low CP (<200 pmol/L) (n=1494) and 4.9% (n=257) had positive GADA (GADA+). In the low-CP group, 8.0% had GADA+ and in the GADA+ group, 46.3% had low CP. The GADA+ group had an adjusted hazard ratio (aHR) of 1.46 (95% CI: 1.15-1.84, p=0.002) for insulin initiation versus the GADA- group, while the low-CP group had an aHR of 0.88 (0.77-1.00, p=0.051) versus the high-CP group. Following insulin initiation, the GADA+ plus low-CP group had the largest decrements in HbA1c (-1.9% at month 6; -1.5% at month 12) versus -1% in the other 3 groups. The aHR of severe hypoglycemia was 1.29 [(95% CI 1.10-1.52), p=0.002] in the low-CP and 1.38 [(95% CI 1.04-1.83) p=0.024] in the GADA+ group. 

Conclusions

There is considerable heterogeneity in autoimmunity and beta-cell dysfunction in T2D with GADA+ and high CP associated with early insulin initiation while GADA+ and low CP, increased risk of severe hypoglycemia. Extended phenotyping is warranted to increase the precision of classification and treatment in T2D.
Online monitoring of focal spasticity treatment with botulinum toxin in people with chronic stroke or hereditary spastic paraplegia: a feasibility study
Authors: Kerstens Hans C. J. W. , Nijkrake Maarten J. , De Swart Bert J. M. , Nijhuis-van der Sanden Ria W. G. , Vos-van de Hulst Marije , Bos Gery J. , Geurts Alexander C. H. , Van der Wees Philip J.
Published: April 2023

Objective: To investigate the feasibility and usability of an online spasticity monitoring tool amongst people with hereditary spastic paraplegia or chronic stroke receiving botulinum toxin treatment, and their healthcare providers.Methods: Mixed methods cohort study, measuring recruitment success and adherence to the monitoring in 3 rehabilitation institutions. In addition, the System Usability Scale (SUS) and interviews with patients and their healthcare providers were used for quantitative and qualitative analysis, respectively. A deductive directed content analysis was used for qualitative evaluation.Results: Of the 19 persons with hereditary spastic paraplegia and 24 with stroke who enrolled in the study, recruitment success and adherence were higher amongst people with hereditary spastic paraplegia compared with stroke. Usability was found “marginal” by rehabilitation physicians and “good” by patients and physical therapists (SUS scores 69, 76, and 83, respectively). According to all participant groups, online monitoring potentially contributes to spasticity management if it is tailored to the actual needs and capabilities of patients, and if it can easily be integrated into the daily/working routines of all users.Conclusion: Online monitoring of spasticity in people with hereditary spastic paraplegia or stroke receiving treatment with botulinum toxin may be feasible, provided that the monitoring tool is tailored to the needs of all users.
LAY ABSTRACTThis study investigated recruitment success and adherence to an online spasticity monitoring tool amongst people with hereditary spastic paraplegia or stroke and their healthcare providers. Usability was evaluated with a questionnaire and interviews. Twenty-four persons with stroke and 19 with hereditary spastic paraplegia participated through 3 rehabilitation institutions. The hereditary spastic paraplegia group was more willing to participate and their adherence to online monitoring was higher than the stroke group. Usability was scored “marginal” by rehabilitation physicians, and “good” by people with spasticity and their physical therapists. The interviews showed that online monitoring may contribute to better spasticity management if it is tailored to the actual needs and capabilities of people with spasticity, and if it can easily be integrated into daily/working routines of all users. Online monitoring of spasticity seems to be feasible. Tailoring the monitoring tool to patients’ needs and capabilities, and the professionals’ routines may further improve feasibility and usability.
Desiminasi Sistem Pembangkit Tenaga Surya untuk Guru dan Siswa di Kabupaten Bandung
Authors: Aprillia Bandiyah Sri , Mohamad Ramdhani  , Irwan Purnama
Published: April 2023

Utilization of solar energy requires an active role from the community by providing information related to solar energy and the potential that can be obtainedIt is necessary to provide guidance to the community by providing basic knowledge about the conversion of solar energy into electricity. Followed by doing practice in proving the basic knowledge given in the form of simple practice. So that the public can understand information related to solar energy as a whole, both basic knowledge, conversion techniques, and installation techniques. The purpose of this community service is to provide training on solar power plant installations as a learning medium in the use of renewable energy in the form of solar energy. The training targets are MA teachers and students as the next generation who in the future will face greater challenges related to energy utilization. MA students are currently required to be more creative and innovative in utilizing all the potential of nature, especially the use of alternative technologies, one of which is solar energy. The Pangalengan area is also a challenge in itself in the use of electricity technology for the need for support by using solar energy for electricity use. In the community service program, an On-Grid 260 Wp solar power plant system has been installed which aims as a learning medium and helps reduce monthly school costs by integrating solar panels for the electrification of the Natural Sciences Laboratory (IPA).
Peningkatan Kualitas Produk Makanan pada UKM di Kota Magelang
Authors: Dewi Rany Puspita , Saputra Trisma Jaya , Budiono Herru Santosa
Published: April 2023

Small Medium Enterprise (SME) Keripik Talas “Sumber Rejeki” is placed approximately 3.6 km from Magelang and produces taro chips. It has been started production in 2010. One of the production processes that is still done traditionally, is oil draining, so the taro chips produced still have high oil content. The purpose of the activity is to escalate the productivity of SME "Jaya Makmur". The activity was done in two phases in Cacaban, Magelang. The first activity began by collecting documentation data and discussion with partner, Mrs. Tuminem. The second acitivity was continued by developing the completion process, application of spinner machine. Measurement the enhancement in productivity is done by measuring the capacity and quality of the chips produced and measurement the enhancement in income is done by calculating the profit before and after the application of the spinner machine. The activity produced the main output, the appropriate technology, that is the spinner machine which capacity of 12 liters and a power of 60 watts and also is equipped with a speed controller and timer. The use of the spinner able to escalate the output capacity which at first 20 kg/day became 40 kg/day with lower oil content. Besides that, it is also able to increase the profits up to 5 times the profits obtained previously.
Optimalisasi Peran Kader Kesehatan dalam Edukasi dan Implementasi Gaya Hidup Sehat Lansia
Authors: Wiyasihati Sundari Indah , Setiawan Hayuris Kinandita , Rejeki Purwo Sri , Herawati Lilik
Published: April 2023

The health problems of the elderly in ​​the Puskesmas Industri, Gresik work area align with the Indonesian health phenomenon where the number of elderly and degenerative diseases is high. Health cadres training in the work area of ​​the Puskesmas Industri is needed to optimize the role of cadres in educating and implementing a healthy lifestyle in older adults. The Community Partnership Program, focusing on health as part of goal 3 of The Sustainable Development Goals (SDGs), was carried out on September 1, 2022, and was attended by 57 cadres from 6 villages. Health information was provided as a provision for cadres to provide education to the public about the healthy lifestyle of the elderly. The results showed that there was an increase of 17,26 points (34,76%) after training. The lowest post-test results were on the topic of BMI and its interpretation, as well as physical activity in the elderly, so further action is needed. During FGD, the Elderly Health Book from the Ministry of Health of the Republic of Indonesia was introduced. The results of the FGD showed that the introduction of the Elderly Health Book should be continued so that health cadres can consistently use it. Health cadres have a significant role in realizing the elderly health program from the Indonesian Ministry of Health. This health cadre training has proven to be very necessary because it can increase understanding as a provision for cadres in providing education to the public regarding the healthy lifestyle of the elderly.
Pendampingan Legalitas Usaha dan Produk UMKM Anggota BMT NU Singgahan
Authors: Moh.Muhajir  , Lukman Khoirin  , Sugito
Published: April 2023

Individuals or groups that produce products, be it food, goods or services, don't just sell without a product identity. As a form of identity for the product that is owned, a brand is needed to provide the identity of the product. The identity of the product can be in the form of a product brand and the legality of the product. In this study, assistance is provided to MSME actors for product legality. Assistance is carried out with the target of BMT NU Singgahan members who have businesses. The assistance was carried out with the first step, namely a business survey owned by BMT NU Singgahan members who are MSME actors. Furthermore, the focus group discussion (FGD). After the FGD, it will be followed by socialization of the mentoring program that will be carried out. In addition to outreach, this study provides training on how to obtain product legality in the form of business registration numbers (NIB), home industry food production certificates (SPP-IRT), halal certificates, and brands registered with the Directorate General of Intellectual Property (DJKI) as well as product financing by BMT NU Singgahan. The resource persons in the training were from the Tuban Health Office, Curator of Curation Houses, Companion for Halal Solution Institute (PPH LSH) ISNU Tuban halal products, and BMT NU Singgahan. From the results of a study that has been conducted, there are 24 MSMEs from 8 villages partnering with BMT NU Singgahan who are willing to be assisted in submitting the legality of MSME products and businesses including NIB, SPP-IRT, halal certificates, and brands registered with the Directorate General of Intellectual Property (DJKI) as well as product financing by BMT NU Singgahan.
Penerapan Model pembelajaran Project Based Learning (PjBL) untuk Meningkatkan Hasil Belajar Bahasa Indonesia Siswa Kelas I Materi Ungkapan Terimakasih, Maaf dan Tolong di SDN Banjarsugihan V/617 Surabaya
Authors:   SDN Banjarsugihan V/617, Surabaya, Murtiningsih Tri Murtiningsih
Published: April 2023

This study aims to determine the increase in activity and learning outcomes of Indonesian language students in grade I at SDN Banjarsugihan V/617, Surabaya, use Project Based Learning (PjBL) learning. This researhed is a classroom action research carried out for two cycles conducted an class I SDN Banjarsugihan V/617 many as 26 students.Cycle I shows the completeness of student learning activities reaching 74.78% and student learning outcomes of 58%. In cycle II, student learning activities increased to 85.89%, while students learning outcomes achieved 88%. Based on the results of the research above, it can be concluding that the use of Project Based Learning (PjBL) learning can increase activities and learning outcomes of Indonesian language material for expressions of thanks, sorry and help class I students at SDN Banjarsugihan V./617 Surabaya semester I 2022-2023 school years. Keywords: Project Based Learning (PjBL), learning outcomes, Learning Activities
Quantitative and Qualitative Assessment of Heavy Metal Risk in a Peri-Urban Area of Central Portugal
Authors: Kikuchi Ryunosuke , Ferreira Carla Sofia Santos
Published: April 2023

Peri-urban areas are characterized by a variety of types of housing, transport infrastructure and multifunctional agriculture, covering extensive areas (ca. 48,000 km2) within the European Union (EU). These areas provide a diverse range of recreation sites and ecosystem services, such as food production. Food security is one of the first priorities for the EU, and there is a critical interface between agriculture and peri-urban land use change. The proximity between urban pollution sources and agricultural areas raises concerns regarding the possible adverse effects of heavy metals contamination on crop quality, and consequent impact on both food security and human health. A field study was performed to assess the risk of soil contamination in a peri-urban area in central Portugal. The total amount and the bioavailable and water-soluble fractions of heavy metals (Cd, Cr, Cu, Pb and Zn) were quantified in the soil samples The results show that heavy metals concentrations were lower than the standard values for soil assessment. However, the bioavailable fraction of Pb was quite variable, depending upon the sampling site. Since only the soluble, exchangeable and chelated metal species in the soils represent the labile fractions available to plants, there is doubt as to how to properly apply the standard values categorized by land utilization to estimate a potential risk relative to metal bioavailability in a multifunctional peri-urban area. It is recommended to standardize a reliable methodology in terms of assessing the risk in soil-crop-human transfer of heavy metals, especially in multifunctional peri-urban areas.
The Free Movement of Albanian Goods toward the European Union
Authors: Mahilaj Sara , Cenaj Marko
Published: April 2023

The free movement of goods is one of the most debatable topics for academics that are focused on European law. One of the four fundamental freedoms of the internal market with the potential to benefit consumers. Because of its complexities, it continues to be important and needs to be continuously studied and analyzed. Given this, the main goal of this paper is to prove if the free movement of Albanian goods toward the European Union is a positive indicator or not for the future. It will be an examination to better understand where we are as a country. To better understand the situation, the analysis will begin with a general overview of the free movement of goods and its significance, followed by a look at the opportunities and challenges that Albania will most likely face in the future. This study attempts to examine the progress of Albania in the area of the free movement of goods, as a country that aspires to be part of the European Union. It models such an analysis, which begins with the first agreement created for this purpose, such as the Stabilization and Association Agreement, and concludes with the most recent creation, The Open Balkan. The analysis conducted through this lens leads Albania to a better future if it adapts to European Union standards, but things cannot be that simple. The true challenges lie deeper and will be visible in the near future.
A adaptação de crianças com autismo na pré-escola: estratégias fundamentadas na Análise do Comportamento Aplicada
Authors: Dos Santos Martins Juliana , Pimentel Höher Camargo Síglia
Published: April 2023

O objetivo do estudo foi analisar se uma intervenção ancorada em estratégias da Análise do Comportamento Aplicada (ABA) pode facilitar o processo de adaptação escolar de crianças com autismo. Os participantes do estudo foram três crianças com autismo, matriculadas em turmas de pré-escolas do município de Pelotas e suas respectivas professoras. A metodologia empregada foi uma pesquisa de caso único, por meio de um delineamento de bases múltiplas entre participantes, cuja coleta de dados ocorreu em duas fases (A e B). Implementou-se uma intervenção baseada em estratégias da ABA, de acordo com as características de cada aluno e com as atividades de cada turma. Os dados coletados se referem a três variáveis: tempo de participação nas atividades, tempo fora das atividades em que os alunos permaneceram engajados em comportamentos disruptivos e frequência de interação com os pares e professores. Os resultados apresentam um aumento estatisticamente significativo na participação e interação de todos os integrantes, e uma redução na emissão de comportamentos disruptivos, que os mantinham fora das atividades. Entende-se como necessários estudos futuros que abordem a temática da adaptação escolar e o uso de estratégias comportamentais para facilitar esse processo com um número maior de participantes e com acompanhamento mais intensivo.
Bingöl İli Ekolojik Koşullarında Bazı Macar Fiği Çeşitlerinin Verim ve Kalite Potansiyellerinin Belirlenmesi
Authors: SİVEREK Emel , ÇAÇAN Erdal
Published: April 2023

Bu çalışma, bazı Macar fiği çeşitlerinin Bingöl ili ekolojik koşullarında verim ve kalite özellikleri ile makro ve mikro element içeriklerinin belirlenmesi ve bu özellikler açısından karşılaştırılması amacıyla yürütülmüştür. Araştırmada 10 adet Macar fiği çeşidi (Aygün, Enes, Sarıefe, Kansur, Oğuz-2002, Akçalar, Anadolu Pembesi 2002, Tarm Beyazı-98, Doğu Beyazı ve Budak) bitkisel materyal olarak kullanılmıştır. Araştırmada, Macar fiği çeşitlerine ait verim özelliklerinden bitki boyu, yeşil ot verimi ve kuru ot verimi, kalite özelliklerinden ham protein oranı (HP), nötr deterjanda çözünmeyen lif (NDF) ve asit deterjanda çözünmeyen lif (ADF), makro elementlerden fosfor (P), potasyum (K), kalsiyum (Ca) ve magnezyum (Mg) oranları ile mikro elementlerden demir (Fe), bakır (Cu), çinko (Zn) ve mangan (Mn) içerikleri ele alınmıştır. Yapılan çalışmada; en yüksek bitki boyu ve yeşil ot verimi Anadolu Pembesi 2022 ve Oğuz-2002 çeşitleri dışında kalan diğer tüm çeşitlerden, en yüksek kuru ot verimi de Aygün, Budak, Doğu Beyazı ve Sarıefe çeşitlerinden alındığı tespit edilmiştir. İncelenen diğer özelliklerden HP, NDF, ADF, P, K, Ca, Mg, Cu, Zn ve Mn içeriklerinin çeşitler arasında istatistiksel olarak bir farklılık göstermediği belirlenmiştir. Sonuç olarak Anadolu Pembesi ve Oğuz-2002 çeşitleri dışında kalan diğer çeşitlerin üstün özellikler gösterdiği belirlenmiştir. Ancak bu çeşitler arasında da Aygün ve Sarıefe çeşitleri kuru ot verimi açısından daha yüksek değerler verdiği için Bingöl ve benzeri ekolojik koşullar için bu iki çeşit tavsiye edilmektedir.
Akdeniz iklimindeki Domates Seralarında Fusarium Solgunluk ve Fusarium Kök & Kök Boğazı Çürüklüğü Hastalık Etmenlerinin Moleküler Tanısı ve Virülenslikleri
Authors: ALTINOK Hacer Handan , CAN Canan , DEMİREL Özge , YÜKSEL Gamze
Published: April 2023

Akdeniz ikliminde Fusarium solgunluğu (Fusarium oxysporum f. sp. lycopersici, Fol) ve Fusarium kök ve kök boğazı çürüklüğü (Fusarium oxysporum f. sp. radicis-lycopersici, Forl) hastalıklarına neden olan fungal etmenler survey çalışmaları ile belirlenmiştir. İzolasyonlar sonucu elde edilen her iki etmene ait izolatların tür/ırk spesifik primerlerle (FOF1-FOR1, sp13, sp23 ve sprl) tanısı yapılmış ve virülenslik grupları oluşturulmuştur. Antalya ilinden izole edilen 42 adet Fol izolatının 20’si ırk 1 (R1), 7’si ırk 2 (R2) ve 15’i ırk 3 (R3) olarak saptanmıştır. Mersin ilinden izole edilen 3 adet Fol izolatı ırk 3 (R3) olarak belirlenmiştir. PCR çalışmalarında sprl primer seti, 58 adet Forl izolatı için 947-bp büyüklüğünde tek amplikon vermiştir. Domates bitkisinden izole edilen toplam 119 adet F. oxysporum izolatının 45’i Fol ve 58’i Forl olarak saptanmıştır. Virülenslikleri açısından, Fol izolatlarının %11’i yüksek virülent (YV), %58’i orta virülent (OV) ve %31’i düşük virülent (DV), Forl izolatlarının ise %28’i yüksek virülent (YV) ve %72’si orta virülent (OV) olarak saptanmıştır.
THE ROLE OF SPORTS MEGA - EVENTS IN THE SUSTAINABLE DEVELOPMENT OF CITIES: A SYSTEMATIC REVIEW
Authors: Xiang Changqing , Wenting Dong , Tengku Kamalden Tengku Fadilah , Ismail Normala , Jie Zhao , Xiaoming Yang , Hua Luo
Published: April 2023

Despite the known contribution of sports events to cities, especially affected by COVID-19 pandemic, residents hold different attitudes to this, for some citizens, sports events continue to play a vital role in cities sustainable development and may contribute to improved life condition and infrastructure in cities, but others do not think so. Although the benefits of sports events are commonly reported, the reasons why some cities and citizens willing to hold sports events are not well understood. This systematic review aimed to identify studies from the literature that the importance of sport mega-events in cities sustainable development synthesize and discuss the reasons for willing to hold sports events reported in the literature. Searches of the e-journal databases including Science Direct, Sport Discus, Scopus, Social Science Citation Index and Arts & Humanities Citation Index were performed. Studies were included that evaluated importance of sports events in cities sustainable development and residents’ attitudes because this is the key point to promote sports events development. The studies included in this review used qualitative, quantitative or mixed methods designs, were peer reviewed, and were published in the English language before the search date. Results: There are 2036 studies identified and after exclusions 30 studies were included in the review (9 qualitative, 10 quantitative, and 11 mixed methods). The review presents several features and findings from the studies, including a description and systematization the role of sports mega-events for cities sustainable development and the main reasons that cities and citizens willing to hold sports events (e.g. increasing job chances, improving the visibility of the city, and taking advantage of opportunities to develop economy). The finding suggest that sports events are an integral part of sustainable development of the city, and sports mega-events were identified as contributing to the city development. Cities and citizens can benefit from various sports events with regard to their development. Sports events play an important role in the sustainable development of cities, and contribute to the political, economic and cultural development of the city. The development of sports events and strategies to promote sustainable urban development should focus on these aspects after COVID-19.
Dominance of Cyperus kyllingia Endl. at guava orchard and its possible resistance to glyphosate
Authors: Ferdinans  , Guntoro Dwi , Sudradjat
Published: April 2023

Weed resistance, indicated by increasing the level of herbicide for control, might arise due to the continuous use of similar herbicides in the long term without any herbicide rotation. The objective of this research was to evaluate the status of dominant weeds in a guava orchard to determine weed control strategies. The research was carried out from November 2020 to June 2021 at Agribusiness Technology Park IPB, Bogor. Vegetation analysis to define dominance was carried out at 4 blocks using the square method. In each block, five sampling points were randomly selected. Seeds of C. kyllingia were collected and planted as many as 25 seedlings in polybags. Glyphosate herbicide was applied onto C. kyllingia in 3 replications using 9 doses, i.e., 0 (D0), 60.75 (D1), 121.5 (D2), 243 (D3), 486 (D4), 972 (D5), 1944 (D6), 3888 (D7), and 7776 g ha-1 (D8). C. kyllingia mortality percentages were analyzed using linear regression to obtain LD50. The results showed that the dominant weed was C. kyllingia. Block 4 showed the highest significant LD50 value at 759.11 g ha-1 with a resistance index of 2.67 (reduced sensitivity). The presence of dominant C. kyllingia was identified only at block 4, indicating the dominance could correlate with increasing resistance of the particular weed.

Keywords: doses; EPSPS; glyphosate; LD50; sedges; vegetation analysis
Association between carcinoembryonic antigen and stages of colorectal cancer: a retrospective study
Authors: AlSubhi Jehan , Balubaid Ibtihal , Khogeer Mawadda , Habadi Rama , Alshaikh Razan , Khinaifis Fatma
Published: April 2023

Background: Colorectal cancer (CRC) is the most common cancer in men and the third most common cancer in women in Saudi Arabia. Carcinoembryonic antigen (CEA) is a complex glycoprotein released by various malignancies, including CRC. It is present in the blood at a modest concentration. The present study aimed at measuring the relationship between CEA levels and colon cancer stage in patients treated at the King Abdulaziz University Hospital (KAUH).
Methods: We conducted this retrospective record review study in the Surgery Department at KAUH, a tertiary facility in Jeddah, Saudi Arabia; the study included 285 patients diagnosed with CRC between 2015 and 2021.
Results: There was a significant relationship between preoperative CEA level and CRC staging (p =
APENDICITE AGUDA: REVISÃO DE LITERATURA
Authors: Silva Juremeira Layane Thainá , Bianchi Mantovan Lívia , Pereira da Silva Veridiana , Dourado Leite Karina , Damasceno de Oliveira Laira Lúcia
Published: April 2023

A apendicite aguda afeta cerca de 10% da população e é, portanto, uma das emergências cirúrgicas mais prevalentes em todo o mundo, representando um importante desafio para os sistemas de saúde. No entanto, a etiologia continua pouco compreendida e o diagnóstico permanece multifatorial. Apesar da disponibilidade de biomarcadores que auxiliam no diagnóstico, a baixa sensibilidade e especificidade limitam seu impacto clínico. O objetivo deste estudo foi  avaliar e sintetizar os resultados obtidos a partir de um levantamento bibliográfico sobre essa patologia, onde foram verificadas informações sobre o diagnóstico e quais biomarcadores e tratamentos atuais estão disponíveis. Para isso, foram revisados diversos artigos científicos sobre o tema, demonstrando que, apesar da diversidade de exames e biomarcadores, o diagnóstico da apendicite aguda permanece complexo. A partir dos resultados analisados, foi verificado que nenhum marcador isolado ou outros testes podem identificar a doença com alta especificidade e sensibilidade, indicando a necessidade de mais estudos sobre a combinação desses marcadores para auxiliar no diagnóstico da apendicite aguda. Neste contexto, o tratamento da apendicite consiste na abordagem cirúrgica com apendicectomia aberta ou laparoscópica. No entanto, a antibioticoterapia pode ser o tratamento de escolha em pacientes com apendicite não complicada, demonstrando ser uma medida terapêutica eficaz pela redução das chances de complicações e nas licenças médicas, além da diminuição do uso de medicação para a dor.
"DIAGNÓSTICO PRECOCE DE ACETONEMIA SUBCLÍNICA EM VACAS HOLANDESAS POR MENSURAÇÃO DE CORPOS CETÔNICOS”
Authors: Grosse Hedron Victor , Hartmann Welington , De Oliveira Rodrigo Azambuja Machado
Published: April 2023

O trabalho foi realizado em uma fazenda de exploração leiteira em Castrolanda, no município de Castro – PR. O sistema de manejo é free-stall, com 220 vacas da raça Holandesa com RHA305 de 6.740 litros. Foram coletadas amostras de sangue de 18 vacas de pré-parto, 4 dias antes da data prevista para o parto; e nos dias 4, 7 e 12 pós-parto, mediante punção venosa coccígea, utilizando-se SnapTest digital Ketovet®, constituindo 72 amostras, no período de fevereiro a maio de 2020. Em 4 vacas o BHB do sangue total apresentou-se acima do limite para cetose subclínica no quarto dia após o parto e 17 apresentaram-se acima do limite no sétimo dia, declinando em seguida, principalmente devido às intervenções clínicas. As médias e desvios-padrão  foram: D -4: 0,89 ± 0,257061; D 4: 1,05 ± 0,283279; D 7: 1,81 ± 0,456131; e D 12: 1,19 ± 0,437762. O benefício do monitoramento de BHB foi a imediata intervenção clínica, evitando-se a severidade por instalação de quadro clínico e as enfermidades concomitantes.
Drag Decomposition Using Partial-Pressure Fields: Ventus-3 and NASA Common Research Model
Authors: Hart Pierce L. , Axten Christopher J. , Maughmer Mark D. , Schmitz Sven
Published: April 2023

The development of partial-pressure field (PPF) theory (Schmitz, S “Drag Decomposition Using Partial-Pressure Fields in the Compressible Navier–Stokes Equations,” AIAA Journal, Vol. 57, No. 5, 2019, pp. 2030–2038) and the application of the concept to conditions relevant to commercial transport aircraft, operating in both the subsonic and transonic regimes (Hart, P. L., and Schmitz, S., “Drag Decomposition using Partial-Pressure Fields: ONERA M6 Wing,” AIAA Journal, Vol. 60, No. 5, 2022 pp. 2941–2951), have shown promise as complements to classical far-field methods. In the present work, a further comprehensive analysis of drag decomposition methods is applied to wing and aircraft configurations. First, the Ventus-3 sailplane wing case demonstrates the ability of PPFs to successfully deconstruct drag on industry-relevant cases including transition modeling and winglets. A quantitative comparison to classical aerodynamic theory and far-field methods supports PPF theory and provides additional insight to viscous–inviscid interaction by means of a viscous interactional aerodynamics term in PPF theory. Second, the NASA Common Research Model is simulated in transonic flow to showcase drag decomposition of full aircraft configurations where PPF applications are used to provide further insight into wave drag sources acting on the aircraft in comparison to classical far-field decomposition methods.
Para una política económica democrática
Authors:   Universidad de Barcelona (España), Costas Antón
Published: April 2023

Many Western citizens feel disenchanted with the economic policy that has been practiced in recent decades. Not only have they not helped to solve their daily problems, but they have aggravated them, increasing inequality, the lack of good jobs and the absence of opportunities. The consequence is that capitalism has stopped working for the benefit of all. This essay analyzes the causes of this derailment of capitalism. The need to build a new social contract for a more effective and equitable democratic economic policy in its results is sustained. The polycrisis we are experiencing opens a window of opportunity for that social contract. It is concluded that when economists offer policies to improve things they should pay more attention to political consent.
"Política económica y nuevos riesgos económicos y sociales: una propuesta con dos pilares"
Authors:   Universidad de Valencia (España), Ochando Claramunt Carlos
Published: April 2023

The purpose of the article is to make an economic policy proposal on two pillars to face the new (and old) socioeconomic challenges (globalization, progress and technological change, demographic changes, inequality and growing social polarization and climate change, among others). The article focuses on an economic policy proposal with two pillars: a) the strengthening of the welfare state and b) the application of a permanent income policy that in the medium and long term allows wage increases in line with productivity growth and, consequently, improve the primary distribution of income in our country.