bluuebunny/crossref_metadata_2025 huggingface dataset:
UPLC-Q-TOF-MS/MS Combined with Network Pharmacology, Molecular
Docking, and Animal Verification Reveals the Mechanism of Insomnia
Treatment by Shen Qi Wu Wei Zi Capsules
Authors: Bai Fengyun , Wang Jie , Xia Ning , Sun Ying , Xie Yundong , Zhao Chongbo , Sun Jing , Zhang Xiaofei
Published: December 2023

Background:

Shen Qi Wu Wei Zi capsules (SQWWZ) are often used to treat
insomnia; however, the potential therapeutic mechanism is still unclear.

Objective:

This study aimed to investigate the mechanism underlying the therapeutic effects of
the Shen Qi Wu Wei Zi capsules on insomnia.

Methods:

The components of SQWWZ were identified using the UPLC-Q-TOF-MS/MS technique in conjunction with relevant literature. Insomnia-related targets were searched in the GeneCards and DisGeNET databases, and the intersection targets were obtained using a Venn diagram. A component-target-insomnia network diagram was constructed using Cytoscape 3.7.2
software. Core targets underwent GO and KEGG enrichment analyses. Molecular docking techniques were employed to verify the key proteins involved in the pathway and their corresponding
compounds. Insomnia was induced in SD rats through the intraperitoneal injection of pchlorophenylalanine (DL-4-chlorophenylalanine, PCPA). The rats were treated orally with
SQWWZ, and the serum levels of 5-HT and GABA in each group were determined using ELISA.
Histological analysis of hippocampal tissue sections from the rats was performed using HE staining.

Results:

Using UPLC-Q-TOF-MS/MS and reviewing relevant literature, we identified 49 components of SQWWZ. Additionally, we obtained 1,043 drug targets and 367 insomnia-related
targets. Among these, 82 targets were found to be common to both drug and insomnia targets.
Following drug administration, rats in the treatment group exhibited a significant increase in the
serum levels of 5-HT and GABA. Moreover, histological analysis using HE staining revealed
neatly arranged hippocampal neuronal cells in the treated rats.

Conclusion:

The active components of SQWWZ had good inhibition of insomnia. This study
provides a reference and guidance for the in-depth study of SQWWZ for the treatment of insomnia.
Illness Anxiety Disorder and Distress among Female Medical and Nursing Students
Authors: Hawamdeh Sana , Moussa Fatchima L. , Al-Rawashdeh Sami , Hawamdih Sajidah Al , Moussa Mahaman. L.
Published: December 2023

Objective:

This study aims to compare the prevalence of illness anxiety disorder (IAD) and distress between medical and nursing students and examine their associations with students' characteristics.

Methods:

Cross-sectional data were collected using the Short Health Anxiety Inventory (SHAI, for measuring IAD) and the Medical Students' Disease (MSD) Perception and Distress Scales.

Results:

Two hundred and sixteen Medical students and 250 Nursing students were recruited from a public female university in Saudi Arabia. Their mean age was 21.27 years. The findings showed that the overall prevalence of IAD (SHAI scores ≥18) among the total sample was 38.8%, with a significantly lower prevalence in medical students compared to the prevalence in nursing students (57.2% vs 17.6%, respectively, X2=45.26, p<.001). Nursing students had significantly higher SHAI scores and lower MSD Perception scores than medical college students, but there were no significant differences among them in the MSD Distress scale. Significant differences in the main study variables scores were reported among nursing students but not among medical students, with the fourth-year level nursing students having higher SHAI and lower MSD Perception and perception scores than other nursing students.

Conclusion:

The highlights that medical and nursing students are susceptible to developing anxiety-related disorders and distress that may have negative impacts on their academic achievements and future careers. Both nursing and medical faculty should help in identifying strategies to support the students' mental health and well-being.
Artificial Neural Networks Approach for Cross-Flow Heat Exchanger Fouling Modeling
Authors: Jradi Rania , Marvillet Christophe , Razak Jeday Mohamed
Published: December 2023

The traditional estimation methods such as fundamental equations,
conventional correlations or developing unique designs from experimental data through
trial and error have limits in thermal engineering due to the complexity of problems
addressed. Thereby, the purpose of the present work is to explain the effective
utilization of the Artificial Neural Networks (ANN) model in heat transfer applications
for thermal problems, like fouling in a heat exchanger. The application of the ANN tool
with different techniques and structures shows that it is an effective and powerful tool
due to its small errors in comparison with experimental data. The feed-forward network
with backpropagation technique was implemented in Mechanical Engineering Technologies and Applicatithis study. Based on sensitivity
analysis, the performance of the network trained was tested, validated and compared to
the experimental data. The results achieved by sensitivity analysis show that ANN can
be used reliably to predict fouling in a heat exchanger. 
Empathy and Equity: Key Considerations for Large Language Model Adoption in Health Care
Authors: Koranteng Erica , Rao Arya , Flores Efren , Lev Michael , Landman Adam , Dreyer Keith , Succi Marc
Published: December 2023

The growing presence of large language models (LLMs) in health care applications holds significant promise for innovative advancements in patient care. However, concerns about ethical implications and potential biases have been raised by various stakeholders. Here, we evaluate the ethics of LLMs in medicine along 2 key axes: empathy and equity. We outline the importance of these factors in novel models of care and develop frameworks for addressing these alongside LLM deployment.
Spontaneous Scaling of a Primary Care Innovation in Real-Life Conditions: Protocol for a Case Study (Preprint)
Authors: Légaré France , G V Mochcovitch Diogo , de Carvalho Corôa Roberta , Gogovor Amédé , Ben Charif Ali , Cameron Cynthia , Plamondon Annie , Cimon Marie , Guay-Bélanger Sabrina , Roch Geneviève , Dumas Pilon Maxine , Paquette Jean-Sébastien , McLean Robert K D , Milat Andrew
Published: December 2023

BACKGROUND

Scaling effective primary care innovations to benefit more people is of interest to decision makers. However, we know little about how promising innovations are being scaled “spontaneously,” that is, without deliberate guidance.

OBJECTIVE

We aim to observe, document, and analyze how, in real-life conditions, 1 primary care innovation spontaneously scales up across Quebec, Canada.

METHODS

We will conduct a participative study using a descriptive single-case study. It will be guided by the McLean and Gargani principles for scaling and reported according to the COREQ (Consolidated Criteria for Reporting Qualitative Research) guidelines. Informed by an integrated knowledge translation approach, our steering committee will include patient users throughout the project. Inspired by the Quebec College of Family Physician’s “Dragons’ Den” primary care program, we will identify a promising primary care innovation that is being or will be scaled spontaneously. We will interview the innovation team about their scaling experiences every month for 1 year. We will conduct interviews and focus groups with decision makers, health care providers, and end users in the innovation team and the target site about their experience of both scaling and receiving the scaled innovation and document meetings as nonparticipant observers. Interview transcripts and documentary data will be analyzed to (1) compare the spontaneous scaling plan and implementation with the McLean and Gargani principles for scaling and (2) determine how it was consistent with or diverged from the 4 McLean and Gargani guiding principles: justification, optimal scale, coordination, and dynamic evaluation.

RESULTS

This study was funded in March 2020 by the Canadian Institutes of Health Research. Recruitment began in November 2023 and data collection began in December 2023. Results are expected to be published in the first quarter of 2024.

CONCLUSIONS

Our study will advance the science of scaling by providing practical evidence–based material about scaling health and social care innovations in real-world settings using the 4 guiding principles of McLean and Gargani.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/54855
Parental autonomy in the care of premature newborns and experience of a neonatal team. (Preprint)
Authors: Piris-Borregas Sr Salvador , Bellón-Vaquerizo Beatriz , Velasco-Echeburúa Leticia , Niño-Díaz Lidia , Sánchez-Aparicio Susana , López-Maestro María , Pallás-Alonso Carmen Rosa
Published: December 2023

UNSTRUCTURED

Introduction. The aim was to study how the time required by families of premature infants to achieve the autonomy in the care of their very low birthweight newborn infants was modified during the implementation of a training program.
Patients and Method. This is an observational prospective study in the context of quality improvement strategy. The Cuídame, what means in English Take care of me program, was aimed at achieving the autonomy of the parents. It was implemented during two periods: period 1, from 1 September 2020 to 15 June 2021, and period 2, from 15 July 2021 to 31 May 2022. The days required by parents to achieve the autonomy in several areas of care were collected from the electronic health system.
Results. A total of 54 and 43 patients were recruited in every period. Less time was required in the period 2 for participation in rounds (10,5 days interquartile range –IQR- 5-20 versus 7 days IQR 4-10,5, p<0,01), feeding (53,5 days IQR 34–68 versus 44,5 days IQR 37–62, p=0,05) and observation of neurobehavior (18 days IQR 9-33 versus 11 days IQR 7-16, p=0,05). More time was required for Kangaroo (14 days IQR 7-23 versus 21 days IQR 10-31, p=0,02), diaper change (9,5 days IQR 4-20 versus 14,5 days IQR 9-32, p=0,04) and infection prevention (1 day IQR 1-2 versus 6 days IQR 3-12, p<0,01).
Conclusion. Families required less time for achieving the autonomy in breastfeeding, observation of neurobehavior and participation in rounds during the implementation. Nevertheless, they required more time for kangaroo, diaper change and infection prevention.
Development and Validation of a Measure for Seeking Health Information in the Diabetes Online Community: Mixed Methods Study (Preprint)
Authors: Hughes Allyson S , Beach Sarah , Vasistha Spruhaa , Heydarian Nazanin , Morera Osvaldo
Published: December 2023

BACKGROUND

Individuals with chronic diseases often search for health information online. The Diabetes Online Community (DOC) is an active community with members who exchange health information; however, few studies have examined health information brokering in the DOC.

OBJECTIVE

The aim of this study was to develop and validate the Attitudes Toward Seeking Health Information Online (ATSHIO) scale in a sample of adults with type 1 diabetes (T1D).

METHODS

People with T1D were recruited through the DOC, specifically Facebook and Twitter. They were provided with a Qualtrics link to complete the survey. This was a mixed methods study that used thematic analysis along with existing theory and formative research to design the quantitative ATSHIO scale.

RESULTS

A total of 166 people with T1D participated in this study. Confirmatory factor analyses determined a 2-factor scale (Trusting and Evaluating Online Health Information in the DOC and Engaging With Online Health Information in the DOC) with good convergent validity and discriminant validity. Correlations were found between social support, online health information–seeking, diabetes distress, and disease management.

CONCLUSIONS

The ATSHIO scale can be used to investigate how people with diabetes are using the internet for obtaining health information, which is especially relevant in the age of telehealth and Health 2.0.
Implementation of a Recovery College Embedded in a Swedish Psychiatry Organization: Qualitative Case Study (Preprint)
Authors: Al-Adili Lina , Malmqvist Moa , Reinius Maria , Helispää Rodriguez Inka , Stenfors Terese , Brommels Mats
Published: December 2023

BACKGROUND

Recovery colleges are service user–led educational interventions aiming at empowering people with mental health issues and promoting recovery through peer learning. Despite the increasing interest in recovery colleges in recent years and the demonstrated beneficial effects for users, there is limited research addressing aspects that influence their implementation. This knowledge is necessary for the successful integration of such interventions in various contexts.

OBJECTIVE

This study aims to explore factors that influence the implementation of a recovery college embedded within a Swedish psychiatry organization.

METHODS

A qualitative case study of a recovery college based on semistructured interviews with 8 course participants, 4 course leaders, and 4 clinical staff was conducted. The transcripts were scrutinized with conventional content analysis, and the interpretation of results was guided by the Consolidated Framework for Implementation Research.

RESULTS

The findings highlight key areas that either hinder or promote the successful implementation of the recovery college. These areas included recruitment, resources, staff attitudes, and ways of organizing courses. Each area has elements that appear both as facilitators and barriers, demonstrating the duality of conditions.

CONCLUSIONS

Allocating dedicated resources, engaging individuals with service user experience as organizers who are willing to share their personal experience, having an open-door policy, creating an open space for participants to share their experiences, and offering practical advice and written material are useful to create favorable conditions for a recovery college to reach its goals of empowering psychiatry service users.
GENÇ SEÇMENLERİN POLİTİK PAZARLAMA UYGULAMALARI İLE İLGİLİ DÜŞÜNCELERİ: KAFKAS ÜNİVERSİTESİ ÖRNEĞİ
Authors: AKGÜL Ebru , TAN Ahmet
Published: December 2023

döneminde minimum maliyet ile maksimum oy elde ederek, iktidara gelebilmek için gerçekleştirmiş oldukları faaliyetlerin tümünü kapsamaktadır. Diğer ülkelere kıyasla ülkemizde politik pazarlama uygulamalarına geç kalınmış olsa da günümüzde siyasi adaylar ve partiler tarafından politik pazarlama faaliyetleri sıklıkla kullanılmaktadır. Bu açıdan politik pazarlamaya baktığımızda daimî bir rekabet söz konusu olduğu görülmektedir. Bir siyasi partinin hedefi potansiyel seçmene ulaşabilmek, seçmeni ikna edebilmek ve muhalefetle farkını yaratıp seçim döneminde iktidara gelebilmektir. Bu araştırmanın temel amacı, Kafkas Üniversitesi’nde okuyan öğrencilerin politik pazarlama uygulamalarına yönelik eğilimlerini belirlemektir.

Yöntem: Bu amaç doğrultusunda, Kafkas Üniversitesinde okuyan 400 öğrenciye yüz yüze anket uygulaması yapılmıştır. Elde edilen veriler SPSS paket istatistik programında, t-testi, ANOVA testi ve Pearson Korelasyon ile analiz edilerek yorumlanmıştır.

Bulgular: Araştırmanın sonucunda; üniversite öğrencilerinin, oy tercihlerinde; politik ürün, partinin lideri, ideolojisi, adayı, programı ve geçmiş çalışmaları gibi faktörlerin daha fazla etkili olduğu sonucuna ulaşılmıştır.

Verilerin analizi sonucunda; erkek öğrenciler, kız öğrencilere kıyasla daha fazla siyasi içerikli haberleri takip etmekte ve siyasi kampanya çalışmalarına daha fazla katılım sağlamaktadır. Aynı zamanda politik pazarlama bileşenlerinin, farklı demografik özelliklere sahip genç seçmen grubunu farklı şekilde etkilediği görülmektedir.

Sonuç: Araştırmanın önemi genç seçmenlerin siyasi faaliyetlere yönelik tutumlarının belirlenmesi ve bu faaliyetlere katılım düzeylerinin ortaya çıkarılmasıdır. Böylece ülkemizde yürütülen siyasi faaliyetlerin ne kadar etkili olduğu ve gençlerin oy verme konusunda bu faaliyetlerden ne ölçüde etkilendiği ortaya konulmaktadır.
PORTFOLIO OPTIMIZATION WITH SEMI-VARIANCE MODEL: AN APPLICATION ON BIST-100 INDEX
Authors: KAHRAMAN Serdar Ramazan , SOMUNCU Kartal
Published: December 2023

Aim: The aim of the study is to compare the performance of portfolios constructed based on variance and semi-variance using data obtained from the BIST-100 Index.

Method: In the study, using the return data obtained from the adjusted weighted average price data of securities in the BIST-100, variance and covariance matrices were constracted to generate optimal portfolios, and the returns of two different portfolios were calculated and compared.

Findings: The findings of the study indicate that, despite securities within the BIST-100 Index generally yielding negative returns during the 2018-2019 period, portfolios constructed based on semi-variance protected investors from the risk of negative returns. It was observed that as the levels of risk tolerance increased, the returns of portfolios also increased.

Conclusions: It has been concluded that portfolios created according to semi-variance offer better protection for investors with low risk tolerance against the risk of unexpected negative returns.
Ketangguhan Wisatawan di Kawasan Malioboro pada Masa Pandemi COVID-19
Authors: Yanti Ni Kadek Winda , Widyaningsih Yulia Arisnani , Wijono Djoko
Published: December 2023

Respon wisatawan di kawasan Malioboro kontras dengan fenomena yang terjadi di masa pandemi yang mana masyarakat cenderung menghindari ruang publik sedangkan kondisi di kawasan Malioboro sebaliknya. Penelitian ini bertujuan untuk memahami lebih dalam terkait ketangguhan atau kemampuan wisatawan di kawasan Malioboro untuk menyesuaikan diri dengan kondisi selama pandemi COVID-19. Penelitian ini melihat ketangguhan dari sudut pandang motivasi berwisata, perilaku wisatawan ketangguhan sosial tingkat individu. Penelitian ini menggunakan data kualitatif yang dikumpulkan melalui metode observasi, wawancara tidak terstruktur, dan wawancara mendalam. Penentuan narasumber, wawancara, dan analisa dilakukan dengan sistem bola salju secara terstruktur. Penelitian ini menemukan bahwa wisatawan di kawasan Malioboro mampu menyesuaikan diri dengan situasi pada masa pandemi COVID-19. Hal ini tercermin dari adanya kesadaran wisatawan terhadap bahaya, namun tetap memilih melakukan wisata dengan mempertimbangkan berbagai upaya pencegahan dan berfokus pada upaya-upaya penyesuaian diri baik oleh individu atau destinasi. Penelitian ini diharapkan berguna untuk manajemen resiko di destinasi dan mitigasi permasalahan terkait pandemi dengan memahami perilaku wisatawan.
Local Resources-Based Community Empowerment Model to Achieve Food Security in the Indonesian Border Community of North Sebatik
Authors: Kurniasih Nia , Mulyani Sekar Inten , Hendris Hendris
Published: December 2023

Many scholars now see border areas to have a srategic value. They are no longer seen as the backyard of a country but the front yard that must be seen well developed. Therefore border communities must be empowered to be independent from neighboring countries. These include efforts to increase these independence through community empowerment. Community empowerment can increase the independence and welfare of the community through increasing knowledge, attitudes/behaviors, skills, abilities, awareness, and utilization of resources. Through the process, it is expected that human resources capacity will increase in food security. How the efforts to empower border communities adopt local resources, instead of a top down approach, however needs forther exploration. This research aims to asses the effects of human and natural capitals in formulating local resources-based Community empowerment model in the sector of food security. This research was conducted in the North Sebatik district, Nunukan regency with 65 sample of farmers selected through simple random sampling techniques. Primary and secondary data were collected through field observations, direct interviews, questionnaire distribution, and information obtained from official government agencies. This research uses human capital, nature capital, and social capital as dependent variables, and community empowerment and food security as independent variables. The analysis method applied Partial Least Square (PLS) by using software WarpPLS 5.0. The results of the research showed that human capital must go through an empowerment process to increase human quality. Natural capital must also go through an empowerment process, as human quality without supported nature resources cannot improve capacity to achieve food security. Social capital must also go through an empowerment process. Community empowerment has an impact on food security, as it can manage existing resources to create and improve household income through locally-based agricultural activities to achieve food security.
Partisipasi Warga pada Penanganan Krisis Akibat Pandemi Covid-19 dalam Tangga Partisipasi Arnstein di Bogoarum, Magetan
Authors: Chawa Anif Fatma , Putra Moch Hisyam , Saputra Andika Riyan
Published: December 2023

Artikel ini bertujuan untuk memahami masalah kuasa (power) dalam implementasi program atau kegiatan yang menggunakan pendekatan atau strategi berbasis komunitas atau community development. Implementasi program pemberdayaan masyarakat menuntut adanya distribusi kekuasaan kepada komunitas melalui proses partisipasi untuk mewujudkan tujuan utama penerapan program yaitu komunitas yang berdaya (empowerment). Diperlukan derajat partisipasi yang tinggi agar distribusi kuasa tersebut bisa terwujud. Penelitian ini menunjukkan bagaimana derajat partisipasi tinggi bisa dicapai pada penerapan Program Kampung Tangguh untuk menangani pandemi covid-19 di Desa Bogoarum. Untuk mengkaji derajat partisipasi komunitas penelitian ini menggunakan teori tangga partisipasi dari Sherry Arnstein yang secara garis besar membagi derajat partisipasi komunitas dalam tiga tingkatan yaitu  kuasa komunitas, ‘ada’ partisipasi dan tidak ada partisipasi. Hasil penelitian menunjukkan bahwa warga desa Bogoarum sudah mengadopsi prinsip utama dari community development yaitu human orientation, partisipasi dan empowerment pada program ppemberdayaan mereka sebelumnya yaitu jimpitan dan Bank Sampah. Hasil penelitian juga menunjukkan bahwa penerapan prinsip ini mendukung tercapainya derajat partisipasi yang tinggi pada penerapan Program Kampung Tangguh Semeru di Desa Bogoarum. Sebagai hasilnya, warga Desa Bogoarum berhasil mengendalikan penularan dan penanganan dampak negatif dari pandemic covid-19
Bourdieu dan Perspektif Alternatif Kajian Jurnalistik
Authors: Krisdinanto Nanang
Published: December 2023

Naskah ini merupakan literature review yang mengelaborasi pikiran Pierre Bourdieu tentang jurnalisme yang dapat digunakan sebagai perspektif alternatif dalam memahami dinamika praktik jurnalistik. Ada dua hal yang membuat pikiran Bourdieu menarik dan penting untuk dikaji dalam konteks jurnalistik. Pertama, perspektif Bourdieu masih jarang digunakan untuk memahami, mengutai, atau menginvestigasi dinamika yang terjadi dalam praktik jurnalistik. Padahal, konsep-konsep kunci seperti arena, habitus, dan modal dapat digunakan untuk menyingkap berbagai dinamika yang terjadi di dalam praktik jurnalistik. Kedua, orientasi teoritik Bourdieu mampu membuka ruang untuk memahami praktik jurnalistik tanpa harus terjebak ke dalam dikotomi perspektif yang kaku di antara perspektif ekonomi politik/organisasional/budaya dan perspektif cultural studies. Konsep kunci Bourdieu dapat digunakan untuk mengungkap kompleksitas praktik jurnalistik yang diabaikan masing-masing perspektif. Konsep kunci Bourdieu juga dapat membuat peneliti terhindar dari bahaya mereduksi praktik jurnalistik menjadi hanya sekadar proses makro (seperti politik, ekonomi, atau budaya yang berbasis struktur sosial objektif), atau sebaliknya hanya sebatas proses mikro (yang berbasis kebebasan atau kreativitas subjek). Dengan kata lain, konsep kunci Bourdieu digunakan sebagai alat analisis yang mampu mengkoneksikan dinamika praktik jurnalistik dengan struktur politik, ekonomi, sosial, atau budaya yang melingkupinya
Games, Speed Effect dan Dampaknya terhadap Manusia: Dromologi dalam Perkembangan Game Online Mobile MOBA (Multiplayer Online Battle Arena)
Authors: Pratama Tito Ari , Nugroho Heru
Published: December 2023

Penelitian ini bertujuan untuk memahami bagaimana kecepatan teknologi dalam dunia game melalui media Smartphone menyebabkan perubahan gaya bermain yang berpotensi mengubah kehidupan para pemain game di masa depan. Dengan game MOBA merupakan salah satu jenis game yang sangat populer di kalangan komunitas gamer karena mudah dimainkan dimana saja dan fleksibel. Namun kemudahan teknologi membuat pemain sulit melepaskan diri dari belitan kesenangan yang ada pada game sehingga berujung pada stigma buruk bermain game terhadap lingkungan. Analisis ini didasarkan pada teori Dromologi yang dikembangkan oleh Paul Virilio mengenai dromologi dan kesadaran akan teknologi yang semakin canggih, dibantu dengan pandangan terhadap nilai-nilai kemanusiaan yang menjadi fokus penelitian ini. Penelitian ini bersifat kualitatif dengan menggunakan metode etnografi pada komunitas pemain Game MOBA. Hasil penelitian menunjukkan bahwa Mobile Online Games berkembang sangat pesat sehingga memerlukan perhatian terhadap implikasinya terhadap kebutuhan generasi mendatang. Dengan digitalisasi menimbulkan efek kecepatan sehingga menyulitkan manusia untuk mengendalikannya. Dan kemudahan bermain yang dihadirkan menyebabkan perjuangan melalui kecelakaan yang hadir dalam game MOBA yang mereka ikuti. Penelitian ini bertujuan untuk memberikan pengingat tentang dampak potensial dari kecepatan mempengaruhi Mobile Online Game terhadap perkembangan fisik dan emosional manusia.
Rural Identity and Its Roles in Boosting Local Economic Sustainability in Nglanggeran Village of Yogyakarta
Authors: Suminar Ratna Eka , Sastrosasmito Sudaryono , Iskandar Doddy Aditya
Published: December 2023

Contemporary studies on rural areas often focus on rural areas' disadvantages and inabilities to accelerate economic growth and stimulate regional development. Within this dominant perspective, local identity or culture is often seen as obstacles to development. In contrast, this article unpacks how rural identity can develop the local economy and then achieve sustainability in a rural area, which allows us to situate the constructive roles of of rural community in regional development. Drawing from field observation and unstructured interviews with resource persons from Nglanggeran Village in Gunung Kidul Regency, Yogyakarta, we found a reciprocal relationship between rural identity and local economy, of which it forms and reinforces rural sustainability. Our findings emphasize the importance of creating rural identity-based policy to bolster regional economy and development.
Usaha Kecil dan Menengah di Masa Krisis: Kajian Dampak dan Perilaku Usaha Mikro Kecil dan Menengah (Umkm) Saat Pandemi Covid-19 di Desa Sriharjo Imogiri Bantul
Authors: Zarodi Humam , Ruslanjari Dina , Giyarsih Sri Rum
Published: December 2023

Pandemi Covid-19 memberikan dampak pada sektor perekonomian sehingga menyebabkan menurunnya aktivitas perekonomian di Desa Sriharjo khususnya bagi UMKM. Dampak yang dirasakan berupa menurunnya pendapatan akibat sepinya pembeli. Penelitian ini bertujuan untuk membahas dan menganalisis perilaku UMKM dalam menghadapi pandemi Covid-19 serta mengkaji strategi perubahan perilaku UMKM. Penelitian ini didasarkan pada focus group Discussion (FGD), wawancara, dan observasi terhadap UMKM di Desa Sriharjo Kabupaten Bantul Yogyakarta. Secara khusus menganalisis perilaku UMKM berupa pengetahuan, sikap dan tindakan pada masa pandemi Covid-19. Hasil penelitian menunjukkan bahwa pengetahuan, sikap, dan tindakan berpengaruh terhadap perilaku UMKM di Sriharjo. Menyikapi kondisi penuh tantangan di masa pandemi ini, para pelaku UMKM menentang keras adanya protokol kesehatan. Perilaku pelaku tercermin dalam penerapan protokol kesehatan dan adaptasi kebiasaan baru di tempat usaha. Strategi untuk mengatasi dampak ekonomi di Desa Sriharjo antara lain dengan membuat platform online, melalui grup WhatsApp dan website bernama pasardesa.id, untuk kegiatan jual beli. Hal ini difasilitasi berupa bantuan langsung dana desa, bantuan tunai Kementerian Sosial, dan BLT UMKM. Strategi yang dilakukan dalam mengatasi dampak pandemi Covid-19 adalah penyuluhan kepada pelaku UMKM oleh Puskesmas Imogiri II, edukasi dan sosialisasi vaksinasi Covid-19, pemberian bantuan masker, hand sanitizer, tempat cuci tangan portable dan sabun tangan. oleh Dinas Perindustrian dan Perdagangan DIY, serta pengawasan tempat oleh petugas gabungan Pemerintah Desa Sriharjo.
Perubahan Perilaku Komersial dan Marketable Surplus Para Petani Padi di Kabupaten Kebumen
Authors: Lestari Ananda Budi , Rahayu Endang Siti , Marwanti Sri , Antriyandarti Ernoiz
Published: December 2023

Petani dalam usahatani mengalokasikan sebagian hasil produksinya untuk memenuhi kebutuhan rumah tangganya. Akan tetapi, saat ini banyak petani diduga tidak lagi menyimpan sebagian hasil produksi guna memenuhi kebutuhan, sebaliknya petani menjual semua hasil produksinya sehingga mempengaruhi penawaran ke konsumen. Oleh karena itu, berubahnya kebiasaan petani tersebut, dapat mempengaruhi corak usahatani yang dilakukan petani. Tujuan penelitian ini untuk mengetahui marketable surplus padi, mengetahui tingkat komersialisasi pada petani padi, mengidentifikasi penyebab perubahan perilaku petani padi, serta menganalisis faktor-faktor yang berpengaruh terhadap marketable surplus padi di Kabupaten Kebumen. Metode dasar yang dipergunakan di penelitian ini adalah metode analisis deskriptif dengan survey di Kecamatan Ambal, Kecamatan Buluspesantren, dan Kecamatan Kebumen dengan pertimbangan bahwa kecamatan tersebut merupakan tiga urutan kecamatan dengan produksi padi terbanyak di Kabupaten Kebumen. Penentuan daerah dilakukan dengan metode purposive sampling. Metode penentuan sampel dilakukan menggunakan proportional random sampling. Penelitian ini menggunakan 80 orang petani padi sebagai responden. Analisis data yang digunakan adalah analisis marketable surplus, deskriptif, dan regresi linear berganda. Hasil penelitian menunjukkan rata-rata marketable surplus padi di Kabupaten Kebumen pada Tahun 2021 sebesar 4.142,75 Kg/UT atau 70,19% dan termasuk corak usahatani komersial (dijual). Penyebab perubahan perilaku petani dikarenakan adanya pengaruh dari revolusi hijau dan ditandai dengan tenaga kerja luar keluarga lebih banyak digunakan, sehingga sudah mengarah ke petani komersial. Faktor pendapatan total, luas lahan, dan status kepemilikan lahan berpengaruh positif terhadap marketable surplus padi di Kabupaten Kebumen pada tingkat signifikansi 99% dan 95%.
Countering Extremist Ideology and Media Security of the State
Authors: Kirilenko V. P. , Shamakhov V. A. , Alekseev G. V.
Published: December 2023

National security in the media sphere is becoming a multifaceted task related to the implementation of Russia’s cultural sovereignty in the context of digital transformation. Strategic planning for the development of the national media space involves domestic political and diplomatic decisions of a conceptual nature that can ensure the unity of the international information space while countering threats: (1) propaganda of violent extremism, (2) popularization of destructive ideology, (3) reduction of cultural capital level of the party in power and opposition. Operational plans for ensuring media security quite often follow the logic of situational response to threats posed by enemies and implement protective measures in relation to the media space at the national level. In methodological terms, the media security of the state is characterized by systemic practices of ensuring information security (in formal legal analysis), and analysis of threats to cognitive and noospheric security (in the natural science study of communication processes). The research methodology involves the use of the method of participant observation inherent in noxology to classify threats emanating from the mass media. Among the main objectives of the article: analysis of modern Russian political and legal documents aimed at ensuring media security and countering extremism, characterizing the Russian policy of securitization of social problems in the media sphere, delimiting legal political struggle from criminal (extremist and destructive) practices of political communication. The objectives of the study include the analysis of foreign experience in ensuring national media security in the context of digitalization and the growing threat of violent extremism. The logic of competition in the digital cultural space practically excludes the use of secrecy, censorship and forcing the audience to watch propaganda in the process of ensuring media security. Public relations in the media sphere involves the choice of media content by the audience of the global information space, which means that the protection of national spiritual and moral values is implemented in the liberal paradigm and demands open dialogue between the party in power and the opposition on topical issues of national security.
On Two Methods for Analyzing the Activities of Enterprises in the Real Sector of the Economy in the Commodity Market
Authors: Tsatsulin A. N.
Published: December 2023

The article is devoted to the consideration of two conceptual approaches to assessing the state and prospects for the development of economic entities in the real sector of the economy on the example of the so-called “golden rule” of the economy and the balanced scorecard. The relevance of the material of the article lies in the fact that the borrowed foreign methodology for studying the actual state of the enterprise, however, allows not only to assess the production and human potential of an economic entity in dynamics of the analyzed period, but also to assist in the development of enterprise development plans for the future of various durations and the development of an individual development strategy in a particular market space in the areas of investment, innovative improvement, marketing policy development, corporate culture, increasing market activity, strengthening business reputation and competitive positions. The purpose of the study is to test the effectiveness of the methodology of both approaches and the effectiveness of the tools used on the examples of enterprises in the real sector of the economy. The index method of statistical research was used as a toolkit when fulfilling both the golden rule and the balanced system of standard technical and economic indicators. The calculations are summarized in tables, illustrated with graphic drawings. The results of the analysis are discussed and commented on taking into account the specific characteristics of the sectoral activities of the selected economic entities. The article draws the necessary conclusions regarding the similarities and differences of the considered methodologies and assesses the prospects for their use in solving applied problems of analysis.
Pela janela da minha casa
Authors: Rodrigues da Conceição Rafaela , Guimarães Teixeira Roberta , Dos Santos Malheiros Gregorio Talita
Published: December 2023

Este artigo é a junção das narrativas de três educadoras/pesquisadoras acerca de ações curriculares com as artes durante o período pandêmico (2020-2022). Com foco nas ‘práticasteorias’[1] de criação e uso, objetiva mostrar a potência das artes e dos artefatos culturais no ‘fazerpensar’ o currículo escolar para além de fundamentalismos pedagógicos, regulações e normatividades. Trazendo conversas e experimentações com arte como método de trabalho, percebemos que a criação de afetos não tem fronteiras virtuais ou físicas. Seu resultado é evidenciar o potencial criador nas adversidades, no conflito entre virtual e real, isolamento e liberdade. As experiências contam que, independentemente dos caminhos e ambientes, a arte potencializa modos de ‘fazerpensar’ os currículos.
O CONCEITO DE REPRESENTAÇÃO NA PERSPECTIVA DA TEORIA DOS CAMPOS CONCEITUAIS DE VERGNAUD
Authors: Pantoja Glauco Cohen Ferreira
Published: December 2023

Embora haja muitas pesquisas utilizando a teoria dos campos conceituais, o conceito de representação, central na psicologia cognitiva ainda é pouco abordado nelas, pois a maioria dessas investigações parece estar focada na detecção de invariantes operatórios. Nesse artigo, retomamos a noção de representação de Gérard Vergnaud e discutimos a diferença entre esse conceito e o de sistemas semióticos, na perspectiva dos Campos Conceituais. Trazemos o modelo de representação de Vergnaud e apresentamos, ainda, uma relação entre representação e realidade pautada nessa visão. Concluímos discutindo a aplicabilidade do conceito para pesquisas empíricas, propondo linhas de investigação relevantes para a pesquisa em conceitualização e reinterpretando problemas antigos persistentes, tais como a “mudança conceitual” e destacando a importância de uma visão desenvolvimental da representação para o Ensino de Ciências e Matemática.
Desenvolvimento de uma proposta curricular de ciências para os primeiros anos de escolaridade
Authors: Silva Patrícia Christine , Rodrigues Ana Valente
Published: December 2023

As preocupações para a promoção da literacia científica para todos estão alinhadas com as recomendações internacionais de organizações como a ONU e OCDE. Diretrizes advogam um ensino das ciências contextualizado, sequencial e sistemático desde os primeiros anos de escolaridade. Em Portugal, o currículo de ciências do ensino primário (6-10 anos de idade) privilegia os conhecimentos em detrimento das capacidades e atitudes e valores e revela a ausência de orientações explícitas para o ensino das ciências o que motivou a sua reformulação. Este artigo descreve o processo de desenvolvimento de uma proposta curricular para o ensino das ciências para os primeiros anos. Adotou-se a metodologia EDR e através da análise comparativa do atual currículo português da área de ciências, para o ensino primário com o de outros países (Singapura, Estados Unidos, Austrália, Inglaterra e Canadá) desenhou-se uma nova proposta de projeto curricular alinhada com uma perspectiva IBSE e orientação CTS.
Analgesic and antiinflammatory activities of the aqueous root extract of Algerian Bunium incrassatum
Authors: Amraoui Nacer , Boutefaha Zineddine , Belattar Noureddine , Arrar Lekhmici
Published: December 2023

The present study was designed to evaluate the antioxidant, analgesic, and antiinflammatory activities of Bunium incrassatum aqueous extract (BIAE) from roots. Tests of radical scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and induced erythrocyte hemolysis using 2,2'-azo bis (2-amidinopropane) dihydrochloride (AAPH) were used for antioxidant activity evaluation. The antiinflammatory activity was tested in Croton oil- and xylene-induced ear edema and carrageenaninduced paw edema. The antinociceptive effect was tested with the pain model induced by formalin and acetic acid-induced writhing response. The results revealed that BIAE exhibited a strong protective effect against AAPH-induced hemolysis of erythrocytes. In contrast, in the DPPH test, BIAE showed moderate activity (IC50: 1.07?}0.078 mg/mL) compared to BHT. In the antiinflammatory test, oral administration of BIAE (100, 300, and 600 mg/kg) significantly reduced the edema in the three models used. In antinociceptive experiments, the pretreatment with BIAE produced important analgesic activity. Additionally, the pretreatment of mice with BIAE significantly reduced the paw-licking time in the second phase. The results of this study revealed the antioxidant, analgesic, and antiinflammatory potential of BIAE, and demonstrated the importance of B. incrassatum as a source of compounds for therapeutic uses.
Outcomes With Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes by Baseline Insulin Resistance
Authors: Ebert Thomas , Anker Stefan D. , Ruilope Luis M. , Fioretto Paola , Fonseca Vivian , Umpierrez Guillermo E. , Birkenfeld Andreas L. , Lawatscheck Robert , Scott Charlie , Rohwedder Katja , Rossing Peter ,   FIDELIO-DKD and FIGARO-DKD Investigators
Published: December 2023

OBJECTIVE

To explore whether insulin resistance, assessed by estimated glucose disposal rate (eGDR), is associated with cardiorenal risk and whether it modifies finerenone efficacy.

RESEARCH DESIGN AND METHODS

In FIDELITY (N = 13,026), patients with type 2 diabetes, either 1) urine albumin-to-creatinine ratio (UACR) of ≥30 to <300 mg/g and estimated glomerular filtration rate (eGFR) of ≥25 to ≤90 mL/min/1.73 m2 or 2) UACR of ≥300 to ≤5,000 mg/g and eGFR of ≥25 mL/min/1.73 m2, who also received optimized renin-angiotensin system blockade, were randomized to finerenone or placebo. Outcomes included cardiovascular (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) and kidney (kidney failure, sustained decrease of ≥57% in eGFR from baseline, or renal death) composites. eGDR was calculated using waist circumference, hypertension status, and glycated hemoglobin for 12,964 patients.

RESULTS

Median eGDR was 4.1 mg/kg/min. eGDR <median (insulin resistant) was associated with higher cardiovascular event incidence regardless of treatment versus ≥median (insulin sensitive) (incidence rate/100 patient-years of 5.18 and 6.34 [for finerenone and placebo] vs. 3.47 and 3.76 [for finerenone and placebo], respectively). However, eGDR was not associated with kidney outcomes. There was no significant heterogeneity for effects of finerenone by eGDR on cardiovascular (<median: hazard ratio [HR] 0.81, 95% CI 0.72–0.92; ≥median: HR = 0.92, 95% CI 0.79–1.06; P interaction = 0.23) or kidney outcomes (<median: HR = 0.84, 95% CI 0.68–1.02; ≥median: HR = 0.70, 95% CI 0.58–0.85; P interaction = 0.28). Overall, finerenone demonstrated similar safety between subgroups. Sensitivity analyses were consistent.

CONCLUSIONS

Insulin resistance was associated with increased cardiovascular (but not kidney) risk and did not modify finerenone efficacy.
Morphology of the knee after guided growth using tension-band devices: a retrospective multicenter study of 222 limbs and 285 implants
Authors: Hvidberg Emma , Antfang Carina , Gosheger Georg , Vogt Bjoern , Abood Ahmed , Møller-San Pedro Alexander , Frommer Adrien , Weyer-Elberich Veronika , Møller-Madsen Maria Kirstine , Roedl Robert , Møller-Madsen Bjarne , Rölfing Jan Duedal
Published: December 2023

Background and purpose: Temporary hemiepiphysiodesis by tension-band devices is commonly applied to correct angular limb deformities in children. We aimed to evaluate knee joint morphology after guided growth using these devices.Patients and methods: In a retrospective multicenter study we analyzed standardized anteroposterior long-leg radiographs of 222 limbs (285 implants) of patients treated by temporary hemiepiphysiodesis with either eight-Plates or FlexTacks for coronal angular deformities of the knee joint between 2013 and 2019. Femoral floor angle (FFA), femoral notch–intercondylar distance (FNID), and tibial roof angle (TRA) were measured pre- and postoperatively to assess the central knee joint morphology. Statistical exploratory analyses were performed using linear mixed models, t-tests, Wilcoxon signed-rank test, and Mann–Whitney U test.Results: 217 FlexTacks (femur 106, tibia 111) in 104 children and 68 eight-Plates (femur 61, tibia 7) in 35 children were identified. Median time period under growth guidance was 11 months (range 4–42). No statistically significant change in the FFA was detected (eight-Plate: P = 0.2; FlexTack: P = 0.3). A statistically significant difference of the FNID was found in the eight-Plate group (P = 0.02), but not in the FlexTack group (P = 0.3). While TRA increased in both groups, a statistical significance was observed only in the FlexTack group (P < 0.01).Conclusion: We found minor but clinically irrelevant changes in knee morphology after the treatment.
Perfluoroalkyl Substances in the Circumpolar Arctic and Northern Populations
Authors: Bonefeld-Jørgensen Eva Cecilie
Published: December 2023

Persistent organic pollutants including perfluoroalkyl substances (PFAS) are globally ubiquitous contaminants transported with sea currents and atmospheric movements, accumulating in the environment, food-chain, animals and humans and possess a potential health risk including the immune-, neurobehavioral-, and reproductive systems. The profile and concentrations found in humans elicit regional differences that might be related to the countries PFAS use, production, lifestyle, and diet. In the Arctic, the PFAS compounds were never produced or used, however, the Arctic Indigenous and northern populations consuming traditional diet including marine mammals at the top of the food-chain (e.g., whales, seals, polar bears) are particularly exposed to PFAS. This mini review gives a short overview on health effects in the circumpolar Arctic populations and aims to compare the PFAS levels in the Arctic with primary focus on the period 2010-20 and relate the levels with the general national country populations. As expected, regional concentration and profile differences were found over the circumpolar Arctic with the highest level found in Greenland. Moreover, in general the regulated PFAS (perfluorooctane sulfonate, perfluoro-octanoate, perfluorohexane sulfonate) tend to decrease and the unregulated PFAS (e.g., perfluorononanoic acid, perfluorodecanoic acid, perfluoroundecanoic acid) increases in concentration during this period. Generally, the PFAS levels were higher in men than women increasing with age. For most Arctic regions, the PFAS levels were higher compared to the general national country populations.
KOMPETENSI PENULISAN KARYA ILMIAH GURU DALAM PERSPEKTIF AGIL
Authors: Mulyana Mulyana , Wicaksono Luhur , Junanto Tulus , Millah Roihatul
Published: December 2023

This study analyzes academic writing competence among teachers at SMA Negeri 6 Pontianak using Talcott Parsons' AGIL theory. This study involves nine teachers with job classifications IVa/b as participants. Employing qualitative methods, data were collected through in-depth interviews, academic paper observations, and performance document reviews. In the digital age, writing skills are crucial for educators adapting to evolving education trends. Findings reveal inadequate adaptation to educational policies and limited commitment to teacher professionalism. Despite achieving commitment to academic writing, teachers focus on cognitive goals, neglecting practical applications in the classroom and facing resource planning constraints. There is a moderate integration of research findings into teaching tasks. Competence development is sporadic, with a significant percentage having not undergone training, and All respondents lack support for research funding latency. Urgent actions are necessary to improve teachers' policy adaptation, broaden academic writing goals to include practical applications, enhance resource planning, and provide consistent support for competence development through training and financial assistance. This research emphasizes the critical need for comprehensive improvements to address current challenges in teacher professionalism and academic writing competencies, contributing valuable insights for educational policy and practice