Hubungan nilai Neutrophil to Lymphocyte Ratio (NLR) dengan kondisi gaduh gelisah pada pasien psikotik akut dan sementara di Rumah Sakit Jiwa Provinsi Bali
Authors: Witari Putu Kristalina , Parmawati Ni Komang Ayu , Santosa I Ketut Arya , Mahardika I Komang Ana 
Published: May 2024

Background: Increased neutrophil-lymphocyte ratio (NLR) as a marker of inflammation in acute and transient psychotic patients is known to be associated with the severity of the disease. The severity of agitation as measured by the Positive and Negative Syndrome Scale Excited Component (PANSS-EC) is also known to have a relationship with the NLR value in Schizophrenia.
Methods: The study was a cross-sectional study with a retrospective approach. The research subjects were obtained from secondary data from the medical records of Bali Mental Hospital from January 2021 to July 2022. The research sample used a total sample according to the exclusion and inclusion criteria set by the researcher and then statistically analyzed.
Results: A total of 72 patients met the criteria. 46 (64%) patients were male and 26 (36%) were female. The mean age was 35.97 ± 12.05 years. The number of patients according to the degree of agitation based on the PANSS-EC score, respectively, was as follows: moderately severe agitation (score 5) in 5 patients, severe agitation (score 6) in 49 patients, and very severe agitation (score 7) in 18 patients. The mean NLR was 4.85 ± 3.38. This study shows a significant positive relationship between an increase in the degree of restlessness and an increase in the NLR value based on the results of the non-parametric Spearman test with a correlation coefficient of 0.644 (p=0.000).
Conclusion: There is a relationship between NLR and the degree of agitation in acute and transient psychotic patients at Bali Mental Hospital. The high NLR showed a high degree of agitation in acute and transient psychotic patients.
 
Latar Belakang: Peningkatan Neutrophil Lymphocyte Ratio (NLR) sebagai marker inflamasi pada pasien psikotik akut dan sementara diketahui berhubungan dengan derajat keparahan penyakit. Derajat keparahan gaduh gelisah yang diukur dengan Positive and Negative Syndrome Scale Excited Component (PANSS-EC) juga diketahui memiliki hubungan dengan nilai NLR pada skizofrenia.
Metode: Penelitian cross-sectional dengan pendekatan retrospektif. Subjek penelitian didapatkan dari data sekunder rekam medis Rumah Sakit Jiwa Provinsi Bali dari bulan Januari 2021 sampai Juli 2022. Sampel penelitian menggunakan total sampel sesuai dengan kriteria eksklusi dan inklusi yang ditetapkan peneliti kemudian dianalisis secara statistik.
Hasil: Sebanyak 72 pasien yang memenuhi kriteria dengan 46 (64%) pasien laki-laki dan 26 (36%) perempuan. Rerata umur 35.97 ± 12.05 tahun. Jumlah pasien sesuai derajat gaduh gelisah berdasarkan skor PANSS-EC berturut-turut sebagai berikut: gaduh gelisah agak berat (skor 5) 5 pasien, gaduh gelisah berat (skor 6) 49 pasien dan gaduh gelisah sangat berat (skor 7) 18 pasien. Rerata NLR 4,85 ± 3,38. Penelitian ini menunjukkan hubungan positif kuat yang signifikan antara peningkatan derajat gaduh gelisah dan peningkatan nilai NLR berdasarkan hasil uji non-parametrik Spearman dengan koefisien korelasi 0,644 (p=0,000).
Simpulan: Terdapat hubungan antara NLR dengan derajat gaduh gelisah pada pasien psikotik akut dan sementara di Rumah Sakit Jiwa Provinsi Bali. Semakin tinggi NLR menunjukkan semakin tinggi derajat gaduh gelisah pada pasien psikotik akut dan sementara