Abstract 175
Authors: Rajesh Teli Brij , Manglunia Ankit , Swain Jayshree 
Published: February 2023

Introduction: The anthropometric indices (Body Mass Index [BMI], Waist Hip Ratio [WHR] and Waist-to-HeighT Ratio [WHtR]) & Triglyceride-Glucose (TyG) Index have been well documented to be highly correlated with insulin resistance (IR) and Type 2 Diabetes Mellitus (T2DM). However, it is not proven which indicator would be optimal for screening people at risk of T2DM. Hence, this study is intended to correlate the aforementioned markers with Glycemic Parameters in Newly Diagnosed T2DM patients.

Aims and Objectives: To determine the correlation of Triglyceride Glucose (TyG) Index, BMI, Waist Hip Ratio, Waist Height Ratio with FPG, 2hrPPG, HbA1c in Newly Diagnosed T2DM Patients.

Material and Methods: The study included 203 patients with Newly Diagnosed T2DM visiting IMS & SUM Hospital OPD from May to October 2022. Baseline History, Demographic Data, Height, Weight, Waist Circumference, Hip Circumference, FPG, 2hrPPG, HbA1c, Lipid Profile were documented. The TyG Index defined as ln [FPG (mg/dL) × fasting TG (mg/dL)/2] was calculated. Visceral Adiposity Index (VAI) & Body Adiposity Index (BAI) were also computed. Statistical Analysis of data was done using Pearson Correlation and Multiple Logistic Regression.

Results: Out of Study Population of 203,60.5% (121) were Males & 39.5% (82) Females. Proportion of individuals from Rural Area was higher (84.6%). 95% were Non-Vegetarians or Mixed Diet.> 75% of the population was Overweight or Obese. Based on WHR, almost 38% Males and 60% of the Females were above range of 0.85 and 0.70, respectively. 2/3rd of patients had associated Hypertension. Mean VAI 5.59 ± 2.06882 in Males v/s 4.74 ± 2.84 Females. Mean BAI 25.49 ± 8.63 in Males v/s 33.87 ± 11.78 Females. HbA1c, Systolic Blood Pressure, BAI correlated positively with BMI. Age at Presentation positively correlated with the WHtR (r-0.1905, p < 0.024). WHR showed significant positive correlation (r = 0.173, p < 0.036) with HbA1c compared to BMI (r = -0.087, p 0.234) and WHtR (r = -0.050, p 0.544). With 95% CI, Mean Age at Presentation was 46 ± 10.1 years, BMI (kg/m2) was 26.3 (SD ± 5.8), HbA1C (%) was 9.6 (SD ± 2.1), FPG (mg/dL) was 203 (SD ± 82), 2hrPPG was 300 (SD ± 99). Total Cholesterol (TC) 197 (SD ± 40), TG 236 (SD ± 51), LDL-C 123 (SD ± 35), HDL-C 44 (SD ± 9.4). Mean TyG Index was 5.9 (SD ± 0.36). TyG Index showed Significant Positive Correlation with HbA1c (r = 0.355, p <0.003), FPG (r = 0.676, p < 0.0001), 2hrPPG (r = 0.632, p < 0.0001), TC (r = 0.465, p < 0.0001), LDL-C (r = 0.323, p < 0.0001) and TG (r = 0. 664, p < 0.0001), Positive Correlation across HbA1c Groups-5.1 (HbA1c < 7%), 5.3 (HbA1c 7-9%) & 5.5 (HbA1c >11%), Positive Correlation with VAI (r = 0.465, p < 0.0001) but not with BAI (r = 0.107, p 0.333), Comparable values across Categories of BMI- Normal Weight (BMI < 18.5-22.9) Kg/m2), Overweight (BMI 23-24.9 Kg/m2), Obese I (BMI 25-29.9 Kg/m2) & Obese II (BMI >30 Kg/m2), Comparable values in Males (Mean 5.23 ± 0.38) and Females (Mean 5.25393 ± 0.31).

Conclusions: Rural Population still needs more Awareness & Screening Programmes. TyG Index and Waist Hip Ratio can be used as Simple Tools for Screening People at Risk for T2DM. TyG Index is a useful Predictor of Glycemic Status across BMI Categories.