bluuebunny/crossref_metadata_2025 huggingface dataset:
Slowly Progressive Limb-Girdle Weakness and HyperCKemia – Limb Girdle Muscular Dystrophy or Anti-3-Hydroxy-3-Methylglutaryl-CoA-Reductase-Myopathy?
Authors: Hiebeler Miriam , Franke Raimo , Ingenerf Maria , Krause Sabine , Mohassel Payam , Pak Katherine , Mammen Andrew , Schoser Benedikt , Bönnemann Carsten G. , Walter Maggie C.
Published: June 2022

Background:

Anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)-myopathy is a usually rapidly progressive form of immune-mediated necrotizing myopathy (IMNM). Rarer clinical courses show slow progression and resemble the phenotype of limb-girdle dystrophy (LGMD).

Objective:

We demonstrate the difficulties in differentiating LGMD versus anti-HMGCR-myopathy.

Methods:

We report on a 48-year-old patient with slowly progressive tetraparesis and hyperCKemia for more than 20 years.

Results:

Due to myopathic changes in initial and second muscle biopsy and typical clinical presentation, the patient was diagnosed with LGMD 20 years ago; despite comprehensive genetic testing including exome diagnostics, the genetic cause of disease could not be identified. Finally, HMG-CoA reductase antibodies were detected, confirming the diagnosis of anti-HMGCR-myopathy. By re-work-up of a second muscle biopsy specimen from year 2009, the diagnosis of a IMNM was made in retrospect. Seven cycles of high-dose immunoglobulins were administered; patient reported outcome measures have mildly improved.

Conclusion:

Patients with clinical LGMD phenotype, degenerative changes in muscle biopsy but without genetic confirmation of the disease should be tested for HMG-CoA-myopathy, thereby allowing for an early start of treatment.
Neurocognitive, behavioral and socio-adaptive functioning assessment in a case of Coffin-Siris syndrome: A holistic approach/perspective beyond the identification of the disorder
Authors: Lohiya Nirali , Chalipat Shiji , Lohiya Nikhil , Malwade Sudhir
Published: June 2022

PURPOSE: Coffin-Siris syndrome (CSS) is a rare genetic disorder characterized by the presence of particular facies, congenital malformations, intellectual developmental disorder, behavioral issues, and speech and language impairment. Thorough neuropsychological assessments in the case of CSS have been reported infrequently, and its subdomains are poorly defined. A detailed description of the clinical, neurocognitive, behavioral, socio-adaptive sequelae of the patient with CSS is provided. RESULTS: The clinical diagnosis in the patient was confirmed by genetic analysis, which identified the presence of mutation of ARID1B gene; the parents’ Sanger sequencing reported normal. The neuropsychological assessments revealed borderline intellectual functioning (IQ-75, verbal > performance) with a mild socio-adaptive deficit score of 64 as suggested by the adaptive scale. The behavioral profile reported that the child had significant difficulties in the attention subdomain with concern in social and thought subdomains. The child met the profile for mild severity of Autism Spectrum Disorder and did not meet the criteria for Attention Deficit Hyperactivity Disorder. In addition, the child had scholastic difficulties in reading and mathematical skills. CONCLUSION: Neurocognitive, behavioral, socio-adaptive functioning and comorbidity assessment in order to provide holistic management of such children after thorough evaluation is essential for their overall functioning.
Radio frequency identification technology in logistics: A review of the literature
Authors: Casella Giorgia , Filippelli Serena , Bigliardi Barbara , Bottani Eleonora
Published: June 2022

Radio frequency identification technology offers various potential benefits compared to the traditional systems of automatic identification, such as barcodes or manual data entry. Thanks to non-contact reading, no need for human intervention and real time information update, that technology increases the speed of identification, material, and information flow and plays an important role in various logistics activities. This is why, since its introduction, radio frequency identification has always been indicated by researchers and practitioners as the technology that will have changed the way of managing logistics and supply chain processes. By means of a systematic literature review on 95 selected papers, this study proposes an examination of radio frequency identification applications targeting the logistics field, with the purpose of categorizing the available knowledge, examining the state-of-the-art solutions and highlighting the key benefits of the technology within the logistics sector. As a result, the trends of the topics treated in studies targeting radio frequency identification in logistics are delineated. Suggestions for future research directions are provided.
The trade-off between the risk of disclosure and data utility in SDC: A case of data from a survey of accidents at work1
Authors: Młodak Andrzej , Pietrzak Michał , Józefowski Tomasz
Published: June 2022

One of the key problems associated with Statistical Disclosure Control is ensuring an optimal trade-off between minimizing the risk of unit identification and maximizing the utility of data to be disseminated (which means minimizing information loss due to the application of SDC methods). In practice, it is usually achieved by defining how much risk can be accepted for any given unit, and then doing the best to modify the data set so that the risk is below the preset threshold while maximising the utility. Moreover, variables from statistical surveys vary not only in terms of their measurement scale but also as regards the role they play in the SDC process. All these aspects should therefore be taken into account when one tries to find this trade-off. In the paper we present a way of assessing whether an optimal trade-off has been achieved. Two main aspects of measuring the risk of disclosure are discussed. The first one is internal risk, i.e. the risk of disclosing confidential information only on the basis on disseminated microdata after the application of SDC (i.e. no attempt of combining data with external information is made); the second one is external risk, when the user has access to an alternative data set containing information that can be linked with statistical data in order to identify a unit. We show that it is possible to measure external risk and information loss while accounting for the measurement scale of variables. In our empirical study we used data from an annual survey of accidents at work for 2017. We compared complex information loss and the risk of disclosure in the original data files and those subjected to SDC using methods implemented in the new working version of the sdcMicro R package. We present the underlying assumptions and results of the SDC process, highlighting the benefits and drawbacks of the tools used in the study, which was conducted in 2020 and 2021 in the Centre for Small Area Estimation at the Statistical Office in Poznań.
Relationship between EMG features and force in orbicularis oris muscle
Authors: Wang Lan , Wu Yanqi , Zhu Min , Zhao Cuilian
Published: June 2022

BACKGROUND: Lip incompetence resulting from mouth breathing is a common clinical manifestation, while there are no definite indicators of amplitude and intensity of muscle functional training in clinical practice, which leads to unsatisfactory training results. OBJECTIVE: The aim was to quantify the relationship between electromyography (EMG) and force in orbicularis oris muscle, so that the indicators of muscle functional training can be evaluated using EMG signals, so as to improve the training effects. METHODS: The EMG and the force signals of orbicularis oris muscle from 0% to 100% MVC within 5 s in twelve healthy subjects (six males and six females; age, 25 ± 2 years; mass, 60 ± 15 kg) were recorded simultaneously for three trials. Four EMG features consisting of RMS, WAMP, SampEn and FuzzyEn were analyzed. The regression analyses were performed using first-order and third-order polynomial model. RESULTS: There were high correlations between the four EMG features and muscle force with the two models. The third-order model yielded a higher coefficient of determination (R2) than the linear model (p< 0.001) and the result of FuzzyEn (R2: 0.884 ± 0.059) was the highest in the four features. CONCLUSION: The third-order model with FuzzyEn of EMG signals may be used to guide the muscle functional training.
Caracterización del mercado de contado y forward peso-dólar en Colombia: un análisis de la microestructura del mercado durante el periodo 2013 a 2020
Authors: Ariza-Murillo Sara , Barreto-Ramírez Ittza Alejandra , Martínez-Cruz Diego Alejandro , Ruiz-Cardozo Cristhian Hernando
Published: June 2022

En este estudio se realiza una caracterización de la microestructura del mercado cambiario de contado y forward peso-dólar en Colombia, con el objetivo de estudiar las principales dinámicas y las interacciones de todos los sectores participantes en esos mercados. Adicionalmente se busca identificar los clústeres económicos presentes en cada uno de los mercados, a través de un análisis de redes ponderadas y dirigidas durante el periodo 2013-2020. Por otra parte, se realiza un análisis descriptivo de los mercados analizados y se identifican características específicas de los montos y precios negociados por cada sector económico y, por ejemplo, se encuentra que el aumento de las negociaciones en el mercado next day y forward durante el periodo analizado estuvo soportado por factores como mayor inversión extranjera, el crecimiento de las inversiones en el exterior por parte de los fondos de pensiones y cesantías y una mayor disposición de los agentes a realizar coberturas frente al riesgo cambiario. En cuanto al análisis de redes se identifican clústeres en cada uno de los mercados, los cuales se caracterizan por tener un Intermediario del Mercado Cambiario que se especializa en ciertos sectores.
THE URGENCE OF INSTITUTIONAL ARRANGEMENT OF CITY ADMINISTRATION IN THE IMPLEMENTATION OF LOCAL GOVERNMENT IN DKI JAKARTA PROVINCE
Authors: Sukma Dhany , Sumartono  , Muluk Khairul , Amin Fadillah
Published: June 2022

The purpose of this study was to determine the urgency of the appropriate administrative city institutional arrangement in the administration of the DKI Jakarta Province regional government. The research method used is qualitative research with an analytical descriptive approach. The results of the study show that the dynamics of local government administration in the Central Jakarta Administrative City shows its own complexity. This causes the administrative city institutions to be unable to run fast to provide quick responses to the increasingly complex problems of the administrative city community. In addition, based on the results of the research, the bureaucratic hierarchical structure tends to be unnecessary, especially the sub-district structure. In addition, Ward which has a hierarchy of subordinates than the mayor has the potential to be further strengthened as front-line bureaucrats (street level aueccracy). This is especially the case with the provision of public services and community development at the grassroots level. The challenge of such institutional arrangement is great, especially in the political will of the central government. The asymmetric decentralization embedded in DKI Jakarta which has implications for the institutional form of the Central Jakarta Administrative City requires strong advocacy to encourage the Central Government to revise and form regulations governing institutions in DKI Jakarta.
Biological aspects of cultivation and application of active metabolites of B. subtilis probiotic
Authors: Popov V. S. , Svazlyan G. A. , Naumov N. M.
Published: June 2022

Relevance. In modern research, the topic of metabiotics is considered as one of the current directions in the development of probiotics, in the future — as a new class of metabiotics. The article presents the results of studies during the cultivation of the probiotic microorganism B. subtilis in a grain nutrient medium from naked oats, and a scientific and practical substantiation of an experimental probiotic suspension during the formation of microbiocenosis and metabolism of the gastrointestinal tract in early weaning piglets.

Methods. As the basis of nutrient media for obtaining metabolites of the probiotic culture of Bacillus subtilis, sprouted and non-sprouted oat grains of the naked variety Nemchinovsky were used at the rate of 100 g of crushed raw material per 3 l of water. The mass fraction of proteinogenic amino acids in experimental probiotic suspensions (EPS) was studied by capillary electrophoresis. The scientific and economic experiment was carried out according to the method of A.I. Ovsyanikov, 1976.

Results. In nutrient media based on oats (O, OP), the number of CFU of probiotic microorganisms has a certain variability. The increase in the abundance of B. subtilis CFU continued up to 6 days, in the OP sample it reached 5.8·107 CFU/cm, after what it decreased until 8th day down to 15.5·106 CFU/cm3. At the same time, the synthesis of amino acids is higher compared to control (germinated grain): lysine — in the range of 7.85–10.53 g/l, methionine — 2.03–2.35 g/l, leucine + isoleucine — in the range 5.79– 9.7 g/l. Indicators of protein metabolism are within the physiological norm in piglets of experimental groups. In piglets that received an experimental probiotic suspension, a more pronounced antagonistic effect, during the formation of microbiocenosis, was manifested to conditionally pathogenic bacteriaif they were given B. subtilis, obtained on a medium based on sprouted oats.
Comparative morphological aspect of the study of bones of domestic and wild animals
Authors: Ziruk I. V. , Kopchekchi M. E. , Egunova A. V. , Tarasova A. A.
Published: June 2022

At present, there is not enough information in the available literature about the anatomical features of the skull bones of various animal species, which is relevant when conducting forensic veterinary and medical examinations. Understanding of the structure of living organisms is impossible without anatomical preparations; it is necessary to clearly understand the place and position of each organ, to know all the options for anatomical relationships with neighboring organs. Knowledge of topographic anatomy is extremely important for the practitioner, it is necessary for successful diagnosis and subsequent treatment. The purpose of this work is to compare the bones of the skull of a cat, rabbit and hare, as well as to study their structure and morphometric parameters.

Objects and methods. The objects of the study were the skulls of domestic and wild animals: a domestic outbred cat, a rabbit of the Gray giant breed, a brown hare. The work was carried out in several stages: digestion with the addition of sodium bicarbonate, cleaning, bleaching with a 3% hydrogen peroxide solution, drying, followed by morphometric measurement and visual comparison.

Results. In a cat, the premaxillary bone and supraorbital process are absent, the hook of the pterygoid bone is long and rounded inwards. In rabbit and hare skulls, the anterior and posterior supraorbital processes are present on the frontal bone, and the hook of the pterygoid bone is short, sharp, and straight. The interparietal bone of the hare merged with the occipital, while in the rabbit and cat it exists as an independent bone. The information provided will greatly facilitate the conduct of a veterinary forensic examination in the investigation of crimes related to poaching.
Bilecik Müzesi'nden Bir Grup Lydion
Authors: ERPEHLİVAN Hüseyin
Published: June 2022

Bu makale Afyonkarahisar ve Bursa çevresinden ele geçmiş lydionların araştırılmasını içermektedir. Eserler bugün Bilecik Müzesi’nde korunmaktadır. Buluntu noktalarına dair kayıtlar eksik olsa da tüm olarak elde olan eserlerin mezar buluntusu olması muhtemeldir. Bursa’da ele geçen lydionlar Daskyleion kentiyle, Afyonkarahisar’da ele geçenler ise, Kelainai kentiyle bağlantılı buluntular olabilir. Her iki satraplık merkezinin de önemi tarihi ve arkeolojik kaynaklardan bilinir. Bu yerleşmelerden gelen benzer buluntular daha önce de yayınlanmıştır. Makale kapsamında yapılan araştırmalar ile Bilecik Müzesi lydionlarının Greenwalt Jr.’ın yaptığı sınıflandırma ile geçiş tipi ve geç tipe ait olduğu anlaşılmıştır. Üç grup halinde incelenebilecek eserlerden ilk grup (Kat. 1-3) M.Ö. 6. yüzyılın son çeyreği ile M.Ö. 5. yüzyıl başları arasına tarihlendirilmiştir. İkinci grup (Kat. 4) M.Ö. 5. yüzyıl başlarına, üçüncü grup (Kat. 5-7) ise M.Ö. 5. yüzyılın ortalarına tarihlendirilir. Dolayısıyla bu eserlerin Anadolu’nun Geç Demir Çağı içinde Pers hâkimiyeti altında Akhaimenid Dönemi’ne ait olduğu anlaşılmıştır. Egzotik içerikleri ile lydionlar varsıl kişilerin Pers ya da yerel elitlerin mezarlarına hediye olarak bırakılmış olmalıdır. İçeriklerin kıtlığına paralel olarak azalan lydion ihracatının, M.Ö. 5. yüzyıl boyunca da Anadolu’daki merkezlere devam ettiği görülmektedir. Gerek Daskyleion gerekse Kelainai çevresinden bilinen tümülüs ve diğer mezarlar bu eserlerin orijinal kontekstleri olabilir.
Yerli Zincir Otellerin İK Sayfalarındaki Etik Değerlerin Analizi
Authors: KUMAŞ Gözde , GÜÇLÜ NERGİZ Hatice , BİLGİLİ Bilsen
Published: June 2022

Bu çalışmada, yerli zincir otellerin belirledikleri etik değerlerinin örgütsel veya kişisel açılardan ne şekilde ele alındıklarını tespit etmek amaçlanmıştır. Bu amaç doğrultusunda, yerli zincir otellerin web sitelerinde yer alan bilgiler incelenmiştir. Araştırma nitel yaklaşım ile tasarlanarak, verilerin analizinde “İçerik Analizi” yöntemi uygulanmıştır. Yapılan literatür taraması sonucunda etik kodlar belirlenmiştir. Belirlenen etik kodlar; örgüt ilişkileri ve kişisel beceriler olmak üzere iki ana temada ele alınmış ve her biri beşer alt temaya ayrılmıştır. Örgüt ilişkileri ana teması altında; mükemmeliyeti arama, başkalarına yardım, adalet, şeffaflık ve empati alt temaları bulunurken, kişisel beceriler ana teması altında ise; saygı, dürüstlük, şefkat, sözünde durmak ve mesleki yeterlilik alt temaları bulunmaktadır. Yapılan içerik analizi sonucunda 41 işletmenin 6 tanesinde hiçbir etik kod bulunamamıştır. Ulaşılan sonuçlara göre; örgüt ilişkileri ana teması altındaki etik değerlerin kişisel etik değerlere göre daha fazla önemsendiği tespit edilmiştir. Mesleki anlamda yeterliliğe ve hizmette mükemmeliyeti arama davranışına verilen önemin yerli zincir otel işletmeleri tarafından en fazla önemsenen etik değerler olduğu tespit edilmiştir. Kişilik özelliği olarak değerlendirilebilen sözünde durma davranışı ise işletmeler için en az önemsenen etik değer olarak tespit edilmiştir. Zincir oteller tarafından mesleki yeterliliğin en fazla önemsenen etik değer olarak görüldüğünün tespiti, Küresel Etik İlkeler Bildirgesi’nin 6.ve 9. maddelerinde bahsedilen konular ile de örtüşmektedir.
Design and Development of Domestic Solar Dryer with Comparative Analysis of Nutritional Aspect of Dried Raisins
Authors: Dubey Sonam , Bhayani Khushbu , Bhatt Chitrangi , Maiti Subarna , Mishra Sandhya
Published: June 2022

Solar dryer technology is simple and can be implemented by households and small communities due to its simplicity. The suitable design of the absorber/collector is very vital for any solar drying system as the collector efficiency plays a key role in determining the overall system drying efficiency. To study the practical applicability of a developed solar dryer, grapes were dried in the drying chamber of a designed and developed solar dryer and for comparison, in open sunlight. Faster drying was noted for the grapes dried in the unit. The study on nutritional aspects indicated that solar drying process retained the major nutritional components like total sugars, total proteins and total lipids in raisins. The comparison between the solar dried raisins and open sun dried ones showed a higher ash content of 2.71% with solar dried ones and 1.95% in case of open sun dried raisins. The quantity of MUFA content was also affected by the varying drying practices implemented with 10.95% and 7.12% MUFA in solar dried and open sun dried raisins respectively. The drying technique also affects the bacterial load on raisins as observed in our current study with negligible bacterial growth on on solar dried raisins compared to open dried ones.
Clinical and Genetic Characteristics of Coronaviruses with Particular Emphasis on SARS-CoV-2 Virus
Authors: Iwanicka Joanna , Iwanicki Tomasz , Kaczmarczyk Marcin , Mazur Włodzimierz
Published: June 2022

The rapidly spreading Coronavirus Disease 2019 (COVID-19) pandemic has led to a global health crisis and has left a deep mark on society, culture, and the global economy. Despite considerable efforts made to contain the disease, SARS-CoV-2 still poses a threat on a global scale. The current epidemiological situation caused an urgent need to understand the basic mechanisms of the virus transmission and COVID-19 severe course. This review summarizes current knowledge on clinical courses, diagnostics, treatment, and prevention of COVID-19. Moreover, we have included the latest research results on the genetic characterization of SARS-CoV-2 and genetic determinants of susceptibility and severity to infection.
Genomic Analysis of an Excellent Wine-Making Strain Oenococcus oeni SD-2a
Authors: Liu Longxiang , Peng Shuai , Song Weiyu , Zhao Hongyu , Li Hua , Wang Hua
Published: June 2022

Oenococcus oeni is an important microorganism in wine-making-related engineering, and it improves wine quality and stability through malolactic fermentation. Although the genomes of more than 200 O. oeni strains have been sequenced, only a few include completed genome maps. Here, the genome sequence of O. oeni SD-2a, isolated from Shandong, China, has been determined. It is a fully assembled genome sequence of this strain. The complete genome is 1,989,703 bp with a G+C content of 37.8% without a plasmid. The genome includes almost all the essential genes involved in central metabolic pathways and the stress genes reported in other O. oeni strains. Some natural competence-related genes, like comEA, comEC, comFA, comG operon, and comFC, suggest that O. oeni SD-2a may have natural transformation potential. A comparative genomics analysis revealed 730 gene clusters in O. oeni SD-2a homologous to those in four other lactic acid bacteria species (O. oeni PSU-1, O. oeni CRBO-11381, Lactiplantibacillus plantarum UNQLp11, and Pediococcus pentosaceus KCCM40703). A collinearity analysis showed poor collinearity between O. oeni SD-2a and

O. oeni PSU-1, indicating great differences in their evolutionary histories. The results provide general knowledge of O. oeni SD-2a and lay the foundation for specific gene function analyses.
Análisis de políticas gubernamentales utilizadas para el fortalecimiento de emprendimientos de las madres solteras guayaquileñas
Authors: Mejía-Flores Omar , Barba-López Rómulo , Buendia-Norona Patricio
Published: June 2022

El emprendimiento en Ecuador ha sido apoyado desde diversos frentes, a través de mecanismos políticos establecidos por los entes gubernamentales y las empresas privadas, así como el fortalecimiento de los mismos con el apoyo de microcréditos a las microempresas. Este apoyo busca generar que dichos emprendimientos sean sustentables. Este sostén se ha fortalecido con mayor énfasis en las mujeres ecuatorianas. A razón de esta situación es importante poder analizar las políticas gubernamentales que permitan arrojar una sostenibilidad a estas microempresas desarrolladas por las mujeres, en especial aquellas que son madres solteras de la ciudad de Guayaquil. La metodología aplicada para esta investigación es la de diseño bibliográfico de tipo documental. Como conclusión, las políticas públicas están enfocadas en el desarrollo de normas, leyes y programas que su fin es generar y apoyar al emprendimiento que viene de las bases de la sociedad; lamentablemente, estas acciones no son vinculantes entre sí con el fin de generar una política integral global de apoyo, sumado a la falta de acompañamiento a los emprendimientos; por lo tanto, debe existir una política firme de acompañamiento de los entes gubernamentales para la sostenibilidad de las nuevas organizaciones, fortalecimiento el conocimiento y las técnicas para la generación de los productos y servicios, lo que permitirá primero crear indicadores de eficiencia que se traducen en un incremento de productividad, lo cual da garantía de que los procedimientos se realizan con la calidad pertinente.
Understanding the Mouse Model of Respiratory Allergic Diseases
Authors: Park Sang Chul
Published: June 2022

Respiratory allergic diseases, represented by allergic rhinitis and asthma, show various features due to their complex pathophysiology. Mouse models of respiratory allergic diseases replicate the characteristics of human allergic rhinitis and asthma, including airway inflammation airway hyperresponsiveness. Different phenotypes and immunologic features are shown according to the various strain of mouse; C57BL/6 strain and BALB/c strain are commonly used in allergic rhinitis and asthma. Ovalbumin as well as pathophysiologically relevant allergen, including house dust mite and fungus are generally used. The mouse model protocols usually include allergen sensitization period followed by allergen provocation period. Allergens possibly combined with adjuvant are introduced into mouse via intraperitoneal, subcutaneous, or intranasal route (sensitization period). Then, mouse repetitively inhales allergen by intranasal, intratracheal, or nebulized formation (aerosol), resulting in a robust influx of inflammatory cells in the airways (provocation period). We can evaluate several parameters including nasal rubbing and sneezing count, airway hyperresponsiveness, histological assessment, cellular composition, cytokine expression of nasal and lung tissue, and allergenspecific immunoglobulin of serum. These examinations provide useful information to understand the pathogenesis of allergic rhinitis and asthma and to test the safety and efficacy of new therapeutic agents. The present review analyzes several protocols and considerations as well as similarities and differences of mouse model of allergic rhinitis and asthma in detail.
IMPLEMENTASI VIRTUAL LOCAL AREA NETWORK DENGAN SWITCH PORT PADA PT. MAXINDO MITRA SOLUSI JAKARTA
Authors: Ramadhan Reza Rizky , Wijonarko Bambang
Published: June 2022

PT. Maxindo Mitra Solusi, is a company engaged in internet service providers (ISP) in the work of PT. Maxindo has many divisions, so it is necessary to divide the network segmentation from each division, requires one switch one division device so that it consumes a lot of the remaining switch ports and also purchases a lot of network devices, for that it is needed Implementation of network design that can divide network segments in a physical device. like a layer three switch. For the above problems, PT. Maxindo Mitra Solusi applies the concept of a Virtual Local Area Network (VLAN) with a manageable switch device that functions as a network divider between divisions, to help the Network Development process at PT. Maxindo Mitra Solusi uses the Network Development Life Cycle (NDLC) development method. VLAN implementation can facilitate network troubleshooting and maintenance, and become more organized in providing IP addresses, avoiding broadcast domains, increasing security and increasing network performance.
RANCANG BANGUN SISTEM INFORMASI SIMPAN PINJAM BERBASIS WEB PADA KOPERASI UNIT DESA SOLIAMITRA DEPOK
Authors: Rusdi Ibnu , Mulyani Ade Sri , Telaumbanua Diah Winiasti , Wardani Rini Kusuma
Published: June 2022

The Industrial Era 4.0 is now very rapid with the development of all forms of digital applications to record all transactions that are running. Koperasi Unit Desa (KUD) Soliamitra requires a system in the running business process because the savings system itself uses a desktop-based or computerized system, but when the loan process is still done manually, using Microsoft Excel starting from applying for loans, installment payments to storage data relating to lending to report preparation, so that when recording loan data there are still frequent recording errors, using the web-based savings and loan information system technology is expected to improve service performance for members of the Koperasi Unit Desa (KUD) Soliamitra. In making this information system the author uses the SDLC method with a waterfall model, because step by step can be completed in an ordered and structured manner, and the design drawings using Unified Modeling Language (UML) as analysis and design and using NetBeans software for system implementation Java Servlet based object to support Web Application.
PERANCANGAN SISTEM INFORMASI PENGGAJIAN BERBASIS WEB PADA CV. NADYA PRINTING
Authors: Syarif Arief Rama , Triyadi Tedi
Published: June 2022

Teknologi informasi dimasa sekarang ini semakin berkembang dengan cepat. Teknologi informasi mempunyai peranan penting dalam kehidupan masyarakat , terutama dalam hal bisnis. Proses bisnis mampu berjalan baik dan tersistematis dengan teknologi informasi yang canggih. Penerapan teknologi informasi menjadikan salah satu solusi dalam menunjang kegiatan harian perusahaaan agar lebih efisien dan juga sebagai solusi menangani berbagai permasalahan dalam mencapai tujuan perusahaan yang lebih baik. Teknologi komputer mampu menjadi solusi dalam pemecah masalah dari tingkat yang ringan sampai yang rumit sekalipun. Sistem informasi dan teknologi tersebut menghasilkan suatu proses pengambilan keputusan , perencanaan, dan strategi bisnis perusahaan. CV Nadya Printing merupakan perusahaan jasa percetakan. Sistem penggajian yang digunakan pada CV Nadya Printing masih menggunakan cara  konvensional. Penulis mencoba merancang aplikasi berbasis Web dengan menerapkan model waterfall. Aplikasi tersebut digunakan untuk mempermudah sistem penggajian dan mengakuratkan  perhitungan  gaji  pokok, lembur  dan  pembuatan laporannya bulanan.
Greener Pastures: priorities for a low-footprint, high-value food producing future
Authors: Casey Marie , Chapman David , Stevens David , King Warren , Kerr Graham , Dodd Michael , Catto Warwick , Caradus John
Published: June 2022

The key challenges and opportunities facing the pasture1 resource underpinning New Zealand’s pastoral industries outlined in this paper are drawn from the knowledge, analysis and feedback of 240 pan-pastoral industry stakeholders2 who participated in the Resilient Pastures Symposium (RPS) at Karapiro in May 2021. Information on the Symposium is provided in Appendix B.The RPS was convened in response to concerns about the resilience3 of our pasture base to rapidly changing pressures and expectations. The purpose of this paper is to deliver on the objectives of the Symposium, namely to:• synthesise the current state of our pastures as seen through the various perspectives of the delegates, and;• propose priorities for consideration by key stakeholders, including the significant investors already supporting Research, Development & Extension (RD&E), as they address the challenges ahead
Fundamentals of development of tourist and recreational potential of regions
Authors: Drebot O. , Babikova K. , Oliinyk H.
Published: June 2022

The article considers the main aspects of the development of recreational tourism in the context of European integration. The study showed that the formation of competitive in the international market through the rational use of natural and cultural-historical potential and reconstruction of the existing material and technical base of recreational and tourist infrastructure, ensuring on this basis the implementation of environmental, economic and social interests in environmental protection. including the preservation of ecological balance and rational use of natural resources. It is proved that the use and implementation of the above tasks of regional policy to develop the balance of ecological and economic aspects of recreational tourism in the context of European integration, which will comprehensively combine environmental and economic feasibility and social efficiency and should become a quality regulatory mechanism and their functioning. This will increase the level of balance of the ecological and economic region, promote the rational use of recreational and tourist resources.
Business assets of territorial communities in conditions of war: new challenges and management problems
Authors:   SІ “Institute of Regional Research named after M. I. Dolishniy of the NAS of Ukraine”, VOZNYAK Halyna
Published: June 2022

Introduction. The Russian invasion in Ukraine has generated the socio-economic crisis, a significant loss of assets, damage to infrastructure and industrial and municipal enterprises, the rupture of value chains, etc., at the background of substantial economic problems caused by the consequences of the pandemic in Ukraine and globally. Current economic conditions dictate the need to search for new approaches to the development of an efficient assets management system at the local level in the conditions of war. Purpose. The article aims to analyze the problems of business assets management in territorial communities of Ukraine and to substantiate the directions of their solution in the conditions of war. Results. The article addresses current problems of business assets management in territorial communities in the conditions of war. The following are singled out: lack of reliable information on available assets in a community; limited opportunities and tools of the community’s impact and control over the activity of municipal enterprises; failure of local governments to secure efficient management of enterprises providing housing and utility services due to significant deterioration of their financial situation; the difficulty of assessing the damage to enterprises, loss of assets, the write-off of property, commodity values, cash of enterprises or bad debts as a result of hostilities. Conclusions. The article argues that the challenges, risks, and problems that have aggravated in territorial communities due to new circumstances have to be instantly taken into account as it will contribute to economic stabilization and help resume the work of enterprises and secure economic resilience. The following communities are suggested to be distinguished depending on the risk of economic resilience disturbance: with low risk, increased prospective risk, or in the area of hostilities and in occupation. A range of measures to secure the economic resilience of communities is offered across the types, and possible directions for improving the efficiency of business assets management are recommended. They will serve as an analytical basis in the practice of local governments when modernizing the local development strategies.
On the zeros of the Riemann zeta function on the critical line
Authors: Abe Yukitaka
Published: June 2022

This is the continuation of the previous paper. By the same method as in the proof of the Riemann hypothesis, we prove that every zero of the Riemann zeta function on the critical line is simple for $t>T_0$, where $T_0$ is a constant.
Sum of the Summations of Binomial Expansions with Geometric Series
Authors: Annamalai Chinnaraji
Published: June 2022

This paper presents a theorem on binomial coefficients. This theorem states that sum of the summations of binomial expansions is equal to the sum of a geometric series with the exponents of two.
INVESTIGASI PERENCANAAN PEMBANGUNAN INFRASTRUKTUR
Authors: Hansen Seng
Published: June 2022

Perencanaan infrastruktur merupakan sebuah proses menantang terutama bagi Indonesia yang memiliki sumber daya investasi yang terbatas. Oleh karena itu, para pembuat keputusan perlu memahami proses perencanaan pembangunan infrastruktur dengan baik. Penelitian ini bertujuan untuk menginvestigasi proses perencanaan pembangunan infrastruktur yang diterapkan oleh tiga kementerian terkait di Indonesia, serta mengidentifikasi berbagai aspek yang patut dipertimbangkan dalam proses perencanaan pembangunan infrastruktur kedepannya. Analisis wawancara menemukan bahwa telah terjadi pergeseran paradigma perencanaan pembangunan infrastruktur di Indonesia, yang mencakup pergeseran di bidang tata kelola, pendekatan pengambilan keputusan, aturan administratif, sumber pembiayaan, mindset penganggaran, peranan pemerintah, pendekatan perencanaan, persiapan proyek, dan model proses perencanaan Selain itu, penelitian ini juga berhasil mengidentifikasi berbagai aspek pertimbangan perencanaan infrastruktur di masa mendatang. Dengan demikian, penelitian ini bermanfaat, terutama bagi para pembuat keputusan, dengan memberikan pemahaman yang lebih baik terkait praktik perencanaan pembangunan infrastruktur di Indonesia.
Hubungan Status Gizi dengan Usia Menarche
Authors: Enggar Enggar , Suastuti Ni Putu , Rosiyana Ni Made
Published: June 2022

Introduction: Early menarche age is associated with an increase in body mass index. Nutrient intake also affects the sexual maturity of adolescent girls. Adolescent girls who get early menarche tend to have more weight and height than those who have not. The purpose of this study was to determine the relationship between nutritional status and age of menarche at SMP Negeri 6 Palu. Methods:  This study uses a cross sectional approach, a sample of 45 people from March to July 2020 using purposive sampling technique, measuring nutritional status using BMI and data analysis using chi square. The results showed that there was no relationship between nutritional status and age at menarche, p-value 0.542. The age at which menarche occurs is not affected by either being thin, normal or obese. It is advisable for young women to eat a balanced diet to maintain a healthy nutritional status during menarche. Inadequate nutrition will interfere not only with growth and organ function, but also reproductive function, especially menstrual disorders.
 
 
ABSTRAK
Pendahuluan: Cepatnya usia Menarche dikaitkan dengan meningkatnya Indeks Masa Tubuh. Asupan zat gizi juga mempengaruhi kematangan seksual remaja putri. Remaja putri yang mendapatkan Menarche dini cenderung memiliki berat badan dan tinggi badan yang lebih dibandingkan dengan yang belum Menarche. Tujuan penelitian ini untuk mengetahui hubungan status gizi dengan usia Menarche di SMP Negeri 6 Palu. Metode: Penelitian ini menggunakan pendekatan cross sectional, sampel 45 orang pada bulan Maret sampai Juli 2020 menggunakan teknik purposive sampling, pengukuran status gizi menggunakan IMT dan analisis data menggunakan chi square. Hasil penelitian didaptkan bahwa tidak ada hubungan antara status gizi dengan usia menarche p-value 0,542. usia menarche terjadi tidak dipengaruhi  baik dari kurus, normal atau gemuknya seseorang. Sebaiknya remaja putri mengonsumsi makanan dengan gizi seimbang untuk menjaga status gizi yang sehat selama menarche. Gizi yang tidak adekuat akan mengganggu tidak hanya pertumbuhan dan fungsi organ tubuh, tetapi juga fungsi reproduksi terutama gangguan mentrusi.
Effects of a Dried Neem Leaf Extract on the Growth Performance, Meat Yield and Meat Quality in Skeletal Muscle of Broiler Chickens Under High-Temperature Conditions
Authors: Nakamura Kiriko , Katafuchi Ayumi , Shimamoto Saki , Ogawa Goichiro , Khandelwal Nikhil , Tatsugawa Kenji , Fujita Yoshikazu , Ohtsuka Akira , Ijiri Daichi
Published: June 2022

We aimed to examine the effects of cyclical high ambient temperature (HT) and dried Neem (Azadirachta indica) leaf extract (DNE) supplementation on the growth performance, muscle lipid peroxidation level, and muscle drip loss of broiler chickens. Twenty-four 15-day old broiler chickens (Chunky strain ROSS 308) were divided into four treatment groups that were fed diets with or without 2.0% DNE under thermoneutral (25 ± 1°C) or cyclical HT (35 ± 1°C for 8 h/day) conditions. Supplementation of DNE did not affect the growth performance of the chicks, but HT reduced their feed intake, the weights of breast muscle and heart. In addition, supplementation with DNE ameliorated the negative effects of cyclical HT on feed intake and breast muscle mass. Furthermore, cyclical HT increased the malondialdehyde (MDA) concentration and drip loss over 48 h of storage of the breast muscle, and these effects were ameliorated by DNE. Collectively, we conclude that dietary supplementation with DNE reduces the muscle MDA concentration and drip loss of broiler chickens kept under HT conditions.
Combinatorial CRISPR Interference Library for Enhancing 2,3-BDO Production and Elucidating Key Genes in Cyanobacteria
Authors: Li Hung , Pham Nam Ngoc , Shen Claire R. , Chang Chin-Wei , Tu Yi , Chang Yi-Hao , Tu Jui , Nguyen Mai Thanh Thi , Hu Yu-Chen
Published: June 2022

Cyanobacteria can convert CO2 to chemicals such as 2,3-butanediol (2,3-BDO), rendering them promising for renewable production and carbon neutralization, but their applications are limited by low titers. To enhance cyanobacterial 2,3-BDO production, we developed a combinatorial CRISPR interference (CRISPRi) library strategy. We integrated the 2,3-BDO pathway genes and a CRISPRi library into the cyanobacterium PCC7942 using the orthogonal CRISPR system to overexpress pathway genes and attenuate genes that inhibit 2,3-BDO formation. The combinatorial CRISPRi library strategy allowed us to inhibit fbp, pdh, ppc, and sps (which catalyzes the synthesis of fructose-6-phosphate, acetyl-coenzyme A, oxaloacetate, and sucrose, respectively) at different levels, thereby allowing for rapid screening of a strain that enhances 2,3-BDO production by almost 2-fold to 1583.8 mg/L. Coupled with a statistical model, we elucidated that differentially inhibiting all the four genes enhances 2,3-BDO synthesis to varying degrees. fbp and pdh suppression exerted more profound effects on 2,3-BDO production than ppc and sps suppression, and these four genes can be repressed simultaneously without mutual interference. The CRISPRi library approach paves a new avenue to combinatorial metabolic engineering of cyanobacteria.
Enhanced Glial Reaction and Altered Neuronal Nitric Oxide Synthase are Implicated in Attention Deficit Hyperactivity Disorder
Authors: Zhang Peng , Fang Huyue , Lou Chengjian , Ye Shan , Shen Guanghong , Chen Shijia , Amin Nashwa , Botchway Benson O. A. , Fang Marong
Published: June 2022

Attention deficit hyperactivity disorder (ADHD) has a complex etiology, and its specific causal factors remain to be elucidated. Aberration of nitric oxide synthase (nNOS) and inflammation, together with astrocytic and microglial cells have been continually associated with several neurological disorders, including ADHD. Using spontaneously hypertensive rat (SHR), we investigated the changes in nNOS, inflammatory, microglial and astrocytic markers in the frontal cortex and hippocampus at three different ages: onset of hypertension stage (i.e., 6 weeks after birth of SHR), established hypertension stage (i.e., 12 weeks after birth of SHR) and senescent stage (i.e., 12 months after birth of SHR), and compared with its age-matched normotensive control, Wistar-Kyoto (WKY) rats. A significant upregulation of Iba-1 expression in the senescent stage of SHR was observed. Further, we observed an upregulated nNOS expression in both onset and established stages of SHR, and a downregulated nNOS in the senescent stage. Our study showed an age-related increment of astrogliosis in the cortex and hippocampi of aged SHR. On the basis of our results, alterations in the nNOS and Iba-1 expressions, as well as age-related astrogliosis, may contribute to ADHD pathogenesis.
Managing Manganese: The Role of Manganese Homeostasis in Streptococcal Pathogenesis
Authors: Aggarwal Shifu , Kumaraswami Muthiah
Published: June 2022

Pathogenic streptococci require manganese for survival in the host. In response to invading pathogens, the host recruits nutritional immune effectors at infection sites to withhold manganese from the pathogens and control bacterial growth. The manganese scarcity impairs several streptococcal processes including oxidative stress defenses, de novo DNA synthesis, bacterial survival, and virulence. Emerging evidence suggests that pathogens also encounter manganese toxicity during infection and manganese excess impacts streptococcal virulence by manganese mismetallation of non-cognate molecular targets involved in bacterial antioxidant defenses and cell division. To counter host-imposed manganese stress, the streptococcal species employ a sophisticated sensory system that tightly coordinates manganese stress-specific molecular strategies to negate host induced manganese stress and proliferate in the host. Here we review the molecular details of host-streptococcal interactions in the battle for manganese during infection and the significance of streptococcal effectors involved to bacterial pathophysiology.
Vaginal Microbiota Changes Caused by HPV Infection in Chinese Women
Authors: Zhang Yichan , Xu Xiaolin , Yu Liqun , Shi Xingxian , Min Min , Xiong Lijuan , Pan Jia , Zhang Yong , Liu Peipei , Wu Guizhen , Gao Guolan
Published: June 2022

Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed the relationship between HPV infection and vaginal microecology including 20 HPV types. In Chinese women, L. gasseri–dominated and L. jensenii–dominated clusters were significantly absence. Microbial alpha diversity was significantly higher in HPV-infected and cervical intraepithelial neoplasia (CIN)–diagnosed groups than in healthy control group. Certain bacteria were associated with HPV infection and CIN, including Streptococcus, Prevotella, Chlamydia, Bifidobacterium, Ralstonia, and Aerococcus. With the development of disease, the proportions of community state type III (CST-III) and CST-IV-B gradually increased, whereas the proportions of CST-I and CST-IV-A gradually decreased. In addition, age was an influential factor for HPV infection. With aging, the probability of HPV infection and the proportion of CST-IV-B increase. In conclusion, our study was a large cross-sectional study that evaluated the relationship between vaginal microbiota and HPV infection, and brought essential comparable data.