bluuebunny/crossref_metadata_2025 huggingface dataset:
Respuesta terapéutica de pacientes con malaria por plasmodium falciparum a los antimaláricos y fenotipo y genotipo del citocromo p450
Authors: Guzmán Valentina , Carmona Fonseca Jaime , Cuesta González Fanny
Published: January 2025

En la evaluación de la eficacia a los antimaláricos, la faltade concordancia entre el fenotipo observado In vivo en el paciente (respuesta exitosa, falla) e In vitro en el parásito (sensible, resistente), sugiere que factores como el metabolismo del medicamento en el hospedero pueden cumplir un papeldeterminante. El metabolismo de varios antimaláricos esrealizado por el complejo citocromo P-450 (CYP450) en elhígado (1) y su actividad es vulnerable a la inhibición y a lainducción por: el estado nutricional, el genotipo enzimático y laadministración concomitante de otros medicamentos (2). Laamodiaquina (AQ) es metabolizada al compuesto activo Ndesetilamodiaquina por el CYP2C8 y la mefloquina (MQ) esmetabolizada a carboximefloquina (su forma de excreción), porel CYP3A4; la inhibición del CYP450 puede convertir un metabolismo rápido en lento llevando a concentracionesinefectivas del medicamento, mientras que la inducción puedeacelerar la conversión a su metabolito y favorecer la excreciónrápida del mismo.
Estudio del efecto de los esteroles aislados de la planta solanum nudum en la membrana del glóbulo rojo humano
Authors: López Mary Luz , Segura César , Blair Trujillo Silvia
Published: January 2025

En el mundo existen pocas alternativas terapéuticas para malaria. El Grupo Malaria ha aislado esteroides de la planta Solanum nudum, usada para el tratamiento de fiebres por la edicina tradicional colombiana, y ha encontrado que tienen ctividad antimalárica in vitro e in vivo contra P. falciparum, P. vivax y P. berghei. Los compuestos aislados de S. nudum son de tipo esteroidal y se conoce que los esteroles pueden afectar la elación colesterol/fosfolípidos en la membrana del eritrocito 1), igualmente, pueden cambiar su permeabilidad para Na+ y + (2). En los eritrocitos parasitados con Plasmodium la edistribución del colesterol en la membrana y la presencia de roteínas del parásito aumentan la permeabilidad. En la membrana el eritrocito se presentan microdominios: arreglos de ípidos y colesterol a los cuales se anclan las proteínas a través el glicosilfosfatidilinositol. Se ha observado como la extracción el colesterol de los microdominios del eritrocito interfiere en la invasión del glóbulo rojo por Plasmodium (3), sugiriendo que pueden ser aprovechados funcionalmente como blanco erapéutico. El objetivo de este trabajo es determinar el efecto de los esteroles de la planta Solanum nudum en la membrana el eritrocito humano normal e infectado con P. falciparum, mediante el análisis de permeabilidad y de microdominios.
Ausencia de equivalencia terapéutica de 7 productos genéricos de lincomicina comparados con el compuesto original
Authors: Zuluaga Andrés , Salazar Beatriz , Rodriguez Carlos , Agudelo María , Vesga Omar
Published: January 2025

La equivalencia farmacéutica (EF) como prueba de equivalencia terapéutica (ET) para productos genéricos parenterales (PG) es un dogma ampliamente difundido y aceptado, pero nunca se ha retado experimentalmente [1]. Comparamos la magnitud de los parámetros farmacodinámicos (PD) de los genéricos de lincomicina (LIN) con los del compuesto original (CO), mediante determinación de su eficacia bactericida in vitro e in vivo.
Hierro libre, transferrina y ferritina séricas de niños con desnutrición grave en terapia de recuperación nutricional. Turbo-Antioquia 2004
Authors: Parra S. Beatriz E. , Morales M. Gladis E. , Burgos Herrera Luis Carlos , Bernal Parra Carlos A. , Velásquez R. Claudia M.
Published: January 2025

El hierro libre contribuye a la producción de sustancias oxidativas que alteran la permeabilidad de la membrana celular y originan el edema característico del kwashiorkor (1). La OMS recomienda la suplementación con hierro para niños desnutridos, una vez recuperan el apetito.
Method of the corrected distance for the valuation of real estate: a theoretical proposal in development
Authors: Chacón Mateos Manuel
Published: January 2025

This article presents a novel valuation model by market comparison that requires a minimum application of criteria by the appraiser, thus seeking the highest degree of objectivity possible. The premise that supports the model is that the price differences observed between comparable assets of the same market must be proportional to the dissimilarities (distances) between those same assets, but it shows that not every distance implies a price gap, so a corrected distance is used. As a validation, the results of applying the method to a fictitious case, as well as to two real data sets from the commune of Providencia, in the city of Santiago, Chile, are evaluated. The solution of the model requires the use of non-linear programming, and the examples show that the results are very similar to those obtained by applying Goal Programming, which is another optimization method applicable to the valuation of real estate.
Jóvenes PYMES tecnológicas en España: análisis del ecosistema financiero como factor estratégico en su crecimiento
Authors: Vega Pascual Manuela , Di Pietro Filippo , Palacín-Sánchez María-José , Alfalla-Luque Rafaela
Published: January 2025

Technology companies are fundamental to the development of a country’s economy, so it is essential to analyze possible factors that support their creation and consolidation. This research study the relationship between the growth of young technology companies and the financial ecosystem, characterised by the emergence of new, more agile and flexible sources of finance. Specifically, an empirical analysis is carried out using an indicator of the evolution of the financial environment that takes into account all available alternative sources of external finance. The analysis uses panel data methodology, specifically the Baltagi-Wu GLS estimator with random effects model, on a sample of 158 young technology SMEs from different Spanish regions. The results show, among other things, a positive and significant relationship between the development of the regional financial ecosystem and the growth in turnover and assets of young technology SMEs, indicating that regions with more developed financial ecosystems offer greater opportunities for growth. This has implications for strategic and operational managers, as it confirms that the decision to locate in different regions not only affects aspects such as production and logistics, but also access to sources of finance, which will have a direct impact on sales and asset growth. Likewise, politicians and public managers should be aware of the importance of promoting adequate financial ecosystems that facilitate the development and survival of these companies.
About Applying Semantic Web Technology for Information Modeling in Construction
Authors:   Joint-Stock Company "Atomenergoproekt", Moscow, 105082, Russian Federation, Stolyarov O. N.
Published: January 2025

The article provides justification for using Semantic Web technology to describe an information model of a capital construction project. The proposed technology is compared with current approaches of information modeling.
Development of Prototype Software for the Hardware-Software Complex "Marking Inspection"
Authors:   Ural State University of Economics, Yekaterinburg, 620144, Russian Federation, Kolyeva N. S. , Panov M. A. ,   Ural State University of Economics, Yekaterinburg, 620144, Russian Federation, Kuznetsov V. Е. ,   Ural State University of Economics, Yekaterinburg, 620144, Russian Federation, Yarochkina К. D. ,   Ural State University of Economics, Yekaterinburg, 620144, Russian Federation, Perestenko К. A. ,   Ural State University of Economics, Yekaterinburg, 620144, Russian Federation
Published: January 2025

The results of the analysis of existing approaches to labeling of goods are presented, the requirements of legislation and regulations in this area are considered. Based on the obtained data, a software prototype has been developed that can automate the process of marking verification, which will provide a high level of control and minimize errors. It is expected that the developed prototype will contribute to the efficiency of the labeling process, ensuring not only compliance with regulations, but also improving the overall safety and quality of products offered on the market. The software product is focused on universal application and can be integrated into a variety of business spheres, including production of goods, provision of services, warehouse management and even in areas where a complex process of control over the production and labeling of goods is required.
Hemophagocytic lymphohistiocytosis: literature review and clinical case
Authors: Manaenkov D. A. , Galitsyna A. B. , Falaleeva N. A. , Shuvaev V. A. , Vovchenko A. A. , Ivanov S. A.
Published: January 2025

Hemophagocytic lymphohistiocytosis is a severe hyperinflammatory syndrome induced by aberrantly activated macrophages and cytotoxic.

T cells, the cause of which is most often infection. The article presents a clinical case of hemophagocytic lymphohistiocytosis in a 34-year-old patient with a history of follicular lymphoma, who was treated at the A.F. Tsyba Medical Radiological Research Center. Six courses of R-CHOP were performed for follicular lymphoma with a complete response and further supportive therapy with rituximab. A month after the end of therapy, the patient complained of pain in his right side. According to morpho-immunohistochemical examination, the diagnosis of B-lymphoblastic lymphoma was established. Treatment according to the ALL-2016 protocol at the stage of consolidation III was complicated by a long period of three-stage cytopenia with the addition of sepsis. According to the results of an additional examination and assessment according to risk scales, the diagnosis of hemophagocytic lymphohistiocytosis was confirmed. After a few days of therapy with ruxolitinib, the general somatic status of the patient improved, blood parameters were restored and hematopoiesis was normalized according to myelogram data.

A generalized infectious process can be assumed as the cause of the development of hemophagocytic lymphohistiocytosis in this patient.
Transcutaneous contrast-enhanced sonography for diagnosis of sentinel lymph nodes in early breast cancer
Authors: Khakimova G. G. , Reshetov I. V. , Zikiryakhodzhaev A. D. , Starkova M. V. , Khakimova Sh. G. , Timoshkin V. O.
Published: January 2025

Disease stage and especially condition of the sentinel lymph node (SLN) assessed in patients with breast cancer prior to treatment are among the most important prognostic factors. SLN is the first lymph node in the regional lymph node system receiving lymph outflow from the primary tumor. SLN biopsy with blue dye gradually replaced traditional axillary lymph node dissection as the standard of treatment of early breast cancer. In the recent years, technique of contrast-enhanced sonography with microbubble contrast agents for examination of the lymph system has been studied both in animal and human trials.

Aim of the review is to investigate the effectiveness of transcutaneous contrast-enhanced sonography of the SLN for biopsy and for diagnosis of metastatic SLNs using methylene blue as the standard in patients with early breast cancer.
The prognostic value of the tumor metabolic volume in predicting the response to therapy in patients with diffuse large B-cell lymphoma
Authors: Vovchenko A. A. , Galitsyna A. B. , Falaleevа N. A. , Khodzhibekova M. M. , Shuvaev V. A. , Manaenkov D. A. , Ivanov S. A.
Published: January 2025

Background. Metabolic tumor volume (MTV) is an insufficiently studied parameter of positron emission tomography, combined with computer tomography (PET/CT), which has been gaining increasing interest in modern oncology in recent years. It is important to use MTV as a prognostic marker in diffuse large B-cell lymphoma (DLBCL).

Aim. To analyze the results of therapy in patients with DLBCL and to identify their relationship with MTV, determined by PET/CT data before the start of treatment, after 2 and 6 courses of therapy.

Materials and methods. The prospective study included 80 patients with a morphologically verified diagnosis of DLBCL who were treated at the A.F. Tsyba Medical Radiological Research Center from 2021 to 2024. All patients underwent therapy using R-CHOP regimens (66.25 %) and R-CHOP-like regimens (33.75 %). Each of the patients underwent 3 PET/CT studies with MTV registration – at the staging stage, after 2 and after 6 treatment courses. The median follow-up was 19.5 (4.97–45.53) months. The survival rate was calculated using the Kaplan–Mayer technique, the MTV threshold values were calculated using ROC analysis taking into account the Yuden index.

Results. On the initial PET/CT, the threshold value of MTV was 37.12 cm3 (p = 0.006). In patients with a value above the threshold, failures of classical first-line therapy were statistically significantly more common. The threshold value of MTV in PET/CT after 2 courses of treatment was 19.15 cm3 (p = 0.032), in PET/CT after 6 courses – 8.73 cm3 (p = 0.028). In patients with an MTV value above the threshold, according to the results of PET/CT performed after the 2nd and 6th courses, cases of disease progression were also statistically significantly more frequent.

Conclusion. MTV is a new prognostic factor in modern oncological practice and should be evaluated in all patients with DLBCL and taken into account when making decisions regarding therapy tactics.
The project of the Russian Ultrasound Classification of superficial lymph nodes R-US-Lymph-RADS. Based on the materials of the All-Russian National Congress of Radiation Diagnosticians and Therapists “Radiology – 2024”. May 28–30, 2024, Moscow
Authors: Editorial Article
Published: January 2025

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Accompanying immunotherapy and quality of life in patients with locally advanced non-small cell lung cancer who received simultaneous chemoradiotherapy
Authors: Glukhareva А. Е. , Afonin G. V. , Grivtsova L. Yu. , Ivanov S. A. , Kaprin A. D.
Published: January 2025

Background. Lung cancer continues to be in the leading positions in mortality among all malignant neoplasms; 85 % of all cases are nonsmall cell lung cancer (NSCLC), and in 40 % of patients the process is diagnosed at a common unresectable stage. Chemoradiotherapy is the standard of treatment for this category of patients, which allows to improve the results of local control and overall survival. In Russia, chemoradiotherapy accounts for about 4 % of all treatment methods. Perhaps this is due to high toxicity of this method and, as a result, a deterioration in quality of life of patients.

Aim. To assess the quality of life of patients with locally advanced NSCLC during simultaneous chemoradiotherapy in combination with and without accompanying immunotherapy.

Materials and methods. The study included 60 patients with locally advanced NSCLC. The study group (n = 30) received a radical course of simultaneous chemoradiotherapy with the use of accompanying immunotherapy with azoximer bromide. Patients in the control group (n = 30) underwent a course of simultaneous chemoradiotherapy in the standard mode. We evaluated the criteria of quality of life in patients using questionnaires EORTC QLQ-LC13, EQ-5D-5L, EORTC QLQ-C30.

Results. In the study group, an improvement in most of the parameters of quality of life and a decrease in the severity of symptoms were demonstrated compared with the control group.

Conclusion. The study demonstrated a tendency to reduce hematological toxicity and improve the quality of life of patients with NSCLC. This allows us to consider the possibility of using accompanying immunotherapy in combination with chemoradiotherapy as an additional therapeutic option that improves the quality of life of patients and the tolerability of the treatment.
Epoetin alpha in multiple myeloma: literature review and our own experience
Authors: Soloveva M. V. , Solovev M. V. , Startsev A. A. , Irugova E. Z. , Arutiunian N. K. , Kraizman A. A. , Abakumova A. V. , Mendeleeva L. P.
Published: January 2025

Background. Anemia is the main symptom of multiple myeloma (MM) both at the time of disease onset and during tumor progression. Previously, the main method of anemia treatment was blood transfusion therapy. Currently, blood transfusions are supplemented by erythropoietin (EPO) administration. Safety and effectiveness of the drug have been proven in multiple trials including trials involving oncohematological patients.

Aim. To present the results of using epoetin alpha (Eralfon) in patients with MM complicated by dialysis-dependent myeloma cast nephropathy in real clinical practice; to analyze the literature data on the use of EPO for the treatment of anemia in MM patients.

Materials and methods. A retrospective analysis of a series of clinical observations was carried out: 4 patients with newly diagnosed MM at the ages between 52 and 60 years who underwent treatment at the Department of Hematology and Chemotherapy of Paraproteinemic Hemablastoses with a Bone Marrow and Hematopoietic Stem Cell Transplantation Block. All patients were diagnosed with myeloma cast nephropathy with significantly decreased glomerular filtration rate of 7–15 mL/min requiring renal replacement therapy. At the time of disease diagnosis, median hemoglobin level was 75 g/L, median creatinine level was 517.5 µmole/L. Endogenous EPO level was measured in all patients prior to epoetin alpha prescription: it varied between 2.31 and 149.6 IU/mL. Epoetin alpha (Eralfon) was prescribed at dose 12 000 IU – 0.3 mL subcutaneously 3 times a week. A review of the literature data on the use of EPO in patients with MM was conducted.

Results. All patients at MM onset were dependent on renal replacement therapy and blood transfusion, therefore epoetin alpha was prescribed immediately. In case of renal function recovery and end of dialysis at target hemoglobin levels, administration of the drug was ceased. If dependence on renal replacement therapy persisted, epoetin alpha treatment continued as synthetic function of EPO-producing cells was compromised. In all clinical cases, epoetin alpha therapy was effective.

Conclusion. Clot formation prevention should be kept in mind during epoetin alpha therapy. Decreased requirement for blood transfusions, improved quality of life with favorable safety profile of the drug make epoetin alpha an indispensable part of accompanying therapy in patients with MM and anemia.
Use of transpapillary cholangioscopy in oncology
Authors: Kurdanova M. Yu. , Imaraliev O. T. , Timofeev M. E.
Published: January 2025

Stent migration is an important problem in stenting of the biliary and pancreatic ducts. It can lead to severe consequences including pancreatitis, cholangitis, duct perforation, sepsis, fistula formation. Removal of proximally migrated stents is complicated by duct diameter, their tortuosity, possible strictures.

The article presents 2 clinical cases of proximal migration of plastic stents from the common bile duct with successful use of the SpyGlass system to remove the migrated stents.
USE OF THE EUROPEANISATION CONCEPT FOR THE ANALYSIS OF EUROPEAN INTEGRATION OF UKRAINE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Tkachenko Dmytro
Published: January 2025

The article examines the two-way process, the classification of Europeanization, the mechanisms of Europeanization, for example, the institutional mechanism, the compliance mechanism, the cognitive mechanism, the correlation of the choice of Europeanization or globalization. The evolution and development of relations between the European Union and Ukraine, cooperation in the trade and economic sphere and in the sphere of security are shown. The role in the energy security of the European Union was studied, it was proved that the main advantage of the country lies in its geopolitical location. Political processes and prospects on the way to European integration are analyzed. The process of Europeanization involves a certain change in the consciousness of political and bureaucratic decisionmakers. Therefore, studies of approaches in candidate countries are needed to demonstrate how deep the process of Europeanization of foreign policy is. The research is aimed at determining the mechanisms of intercultural interactions through the phenomenon of Europeanization, the influence on the unification of the cultural and value dimension of European integration.
ÖZEL GEREKSİNİMLİ ÇOCUĞU OLAN EBEVEYNLERİN SIKINTIYA DAYANMA DÜZEYLERİNİN İNCELENMESİ
Authors: Avcanok Mert , Nuri Cahit , Bağlama Başak , Ruştioğlu Omaç
Published: January 2025

Bu araştırmada özel gereksinimli çocuğu olan ebeveynlerin sıkıntıya dayanma düzeyleri farklı değişkenlere göre incelenmeye çalışılmıştır. Araştırmada nicel araştırma yöntemlerinden betimsel tarama modeli kullanılmış olup verilerin toplanmasında kolayda örneklem tekniği kullanılmıştır. Kuzey Kıbrıs Türk Cumhuriyeti’nde Millî Eğitim Bakanlığı’nın bünyesinde bulunan okullarda öğrenimini sürdüren 194 ebeveynin gönüllü katılımı ile veriler toplanmıştır. Ebeveynlere Google Form ile elektronik ortamlarda ulaşılmıştır. Araştırmada veri toplama aracı olarak Ebeveyn Demografik Formu ve Sıkıntıyı Tolere Etme Ölçeği uygulanmıştır. Özel gereksinimli çocuğu olan ebeveynlerin Sıkıntıyı Tolere Etme Ölçeği’nden aldıkları puanlar ile cinsiyet, medeni durum, eğitim ve psikolojik desteğe ihtiyaç duyma durumları arasında istatistiksel olarak anlamlı düzeyde fark bulunurken; ebeveynlerin, Sıkıntıyı Tolere Etme Ölçeği’nden aldıkları puanlar ile yaş grubu, çocuk sayısı ve aylık hane geliri arasında istatistiksel olarak anlamlı düzeyde fark bulunamamıştır. Özel gereksinimli çocuğu olan ebeveynlere bireysel rehberlik ve danışmanlık verilmesinin yanı sıra ebeveynlerden oluşan gruplar oluşturularak grupla rehberlik ve danışmanlık hizmeti verilmesi yarar sağlayabileceği sonucuna varılmıştır.
Postnatal changes in the ultrastructure of myocardial cells in mice with dysferlinopathy (Bla/J line)
Authors: Limaev Igor S. , Yakovlev Ivan A. , Chekmareva Irina A. , Bardakov Sergey N. , Emelin Aleksey M. , Savelyeva Maria A. , Deykin Alexei V. , Deev Roman V.
Published: January 2025

Our abstract is 257 words long. The website requirements state: "Please note that your abstract should be no more than 300 words". However, the online form does not allow us to upload the abstract, even though it fits within the specified limit
Comprehensive hygienic assessment of the working conditions of miners engaged in underground polymetallic ore mining
Authors: Ismailova A. A. , Musina A. A. , Suleimenova R. K. , Tekebaeva A. M. , Zhizhila S. A. , Erdenova G. K.
Published: January 2025

Objective. To carry out a comprehensive hygienic assessment of the working conditions of miners of underground polymetallic ores mining, taking into account various technological operations to predict the risk of the development of health disorders and to optimize labor.
Materials and methods. The object of the study was the miners of the underground ore mining of the Zhezkent mining and processing plant (MPP) of Kazakhmys Corporation LLP in the East Kazakhstan region. Comprehensive hygienic studies on working conditions of various professional groups included an evaluation of microclimatic parameters, illumination, vibroacoustic factors in accordance with the Methodological Recommendations "Hygienic criteria for the assessment and classification of working conditions according to the indicators of harmfulness and danger of the working environment factors, severity and intensity of the labor process".
Results. The results of the hygienic studies of the working conditions of miners of underground polymetallic ore mining of the Zhezkentsky MPP of the Kazakhmys Corporation demonstrated a number of unfavorable production factors. Thus, the relative air humidity varied within 96.1%, the dust content in the air of the working area exceeded the maximum permissible concentration (MPC) by 4.5 times, the noise and general vibration indicators exceeded the MPC from 11dB to 28dB.
Conclusions. The results of a comprehensive hygienic assessment of the working conditions of miners of the underground polymetallic ore mining of the Zhezkentsky MPP allowed us to establish that the working conditions of engineers for mining equipment management by the degree of harmfulness corresponded to the 3rd class of the 3rd degree, and the work of miners of auxiliary professions - to the 3rd class of the 2nd degree.
Endometrioid ovarian cysts: risk factors for recurrence
Authors: Kiselev M. A. , Repina N. B. , Nikiforov A. A. , Nikiforova L. V. , Dmitrieva M. N. , Kiselev A. M.
Published: January 2025

Objective. To determine the risk factors for the recurrence of endometrioid cysts in infertile patients.
Materials and methods. 47 women divided into two distinct groups participated in the study. The first group (n = 39) consisted of women of reproductive age with infertility associated with endometrioid ovarian cysts, who experienced no recurrence of these cysts for a year. Conversely, the second group (n = 8) comprised infertile women of reproductive age, who had a recurrence of endometrioid cysts within the same timeframe. Blood sampling for analysis was performed in all the participants before the surgery, on the 10th day after the operation, and in 6 and 12 months following the surgery. The concentrations of AXIN-1 and haptoglobin were determined in the blood plasma.
Results. Risk factors for the recurrence of endometrioid ovarian cysts such as young age 28.5 (27.5–31.5), dysmenorrhea, bilateral lesion, cyst size of 5 (4–6) cm, as well as the dynamics of AXIN-1 and haptoglobin biomarkers were revealed in the study. A statistically significant difference in the level of haptoglobin which reflects the presence of oxidative stress provoked by ferroptosis in the cysts and beyond them was determined in patients with recurrent endometriomas. The phenomenon of ferroptosis was shown to contribute to fibrosis of not only the tissues of the ovary itself, but also to the formation of adhesions in the appendages, which was most pronounced in the relapse group. High concentrations of AXIN-1 and its slow dynamics of decline in patients with recurrent endometrioid cysts reflect the aggressiveness of cellular proliferation, bypassing apoptosis and leading to repeated relapse. The combination of the above-mentioned biomarkers is also promising for early detection of recurrence of endometrioid ovarian cysts – 6 months after the surgery.
Conclusion. The following clinical, anamnestic, intraoperative and laboratory data were identified as significant risk factors for the recurrence: patients` younger age of 28.5 (27.5–31.5), dysmenorrhea, bilateral nature of the lesion and cyst size of 5 (4–6) cm, as well as the dynamics of biomarkers after surgery. Analysis of the dynamics of AXIN-1 and haptoglobin biomarkers can be considered not only as a criterion for the recurrence of endometrioid cysts, but also as an important aspect of planning surgical intervention, since the connection with the adhesive process was revealed.
Remodeling of vessels of the upper extremities in case of vibration disease in combination with arterial hypertension in the postcovid period
Authors: Shpagina L. A. , Panachevа L. A. , Zolotukhina E. V. , Novikova I. I. , Kuznetsova G. V.
Published: January 2025

Objective. To study the features of vascular remodeling of the upper extremities in patients with I-II degree of vibration disease (VD) from local vibration in combination with arterial hypertension (AH) in the post-COVID period.
Materials and methods. 80 patients with VD and hypertension who had suffered COVID-19 (the main group) were examined. In this group, the mild form of CVI prevailed — 70.0%. The comparison group consisted of 50 patients with similar diagnoses, comparable in age, work experience and duration of the diseases but who hadn`t had COVID—19. The study of the condition of peripheral blood flow of the upper extremities was carried out by rheovasography (RVG) on the rheographic complex "Rheo-Spectrum" before the CVI (during planned hospitalization in the department of occupational pathology), 3 and 12 months after it.
Results. In patients of the main group, the RVG readings of the vessels of the shoulders and hands before CVI practically did not differ from those of the comparison group. In 3 months after COVID-19, patients in the main group showed a moderate decrease in rheographic index, maximum rapid filling rate, average slow filling rate, dicrotic and diastolic indexes, and time of pulse wave propagation from the heart, in relation to the comparison group. 12 months after the CVI, a further decrease in all analyzed parameters was revealed in the same patients.
Conclusions. Remodeling of the vessels of the upper extremities and the common carotid artery occurs in the post-COVID period in I-II-degree VD from local vibration combined with hypertension. 3 months after COVID-19, in patients with VD and hypertension, a decrease in all analyzed indicators was observed in the vessels of the forearm and hands in relation to those who did not have CVI. 12 months after CVI, a further disturbance of peripheral blood flow is revealed according to RVG in the forearms and hands of patients with VD combined with hypertension.
The experience of using an opioid peptide (tyrosyl-D-arginyl-phenylalanyl-glycine amide) in oncological practice
Authors: Lukonina Tatiyana D. , Khoronenko Victoria E. , Abuzarova Guzal R. , Malanova Anna S. , Ageeva Anastasiia A.
Published: January 2025

BACKGROUND: The use of tyrosyl-D-arginyl-phenylalanine-glycine amide, a highly specific μ1-opioid receptor agonist, is one of the most promising new approaches for the treatment of acute postoperative pain.
AIMS: To investigate the efficacy and safety of tyrosyl-D-arginyl-phenylalanine-glycine amide in cancer patients depending on the type of anesthesia used in various types of surgical interventions.
MATERIALS AND METHODS: The study included 80 patients aged 29 to 86 years (mean age 66 years (Q1;Q3 – 59;71 years)), 46 (57.5%) men and 34 (42.5%) women, with a physical status of I–III according to the American Society of Anesthesiologists (ASA) classification, scheduled for surgical treatment of cancer. Patients received a specific type of anesthesia: multimodal combined general anesthesia with mechanical ventilation in the control group (Group K, n=40) or combined anesthesia (general + epidural/intercostal block in thoracic surgeries) in the comparison group (Group C, n=40). All patients followed a general protocol of systemic postoperative pain management based on tyrosyl-D-arginyl-phenylalanine-glycine amide, administered at a dose of 4 mg, 3 times daily. The first dose was given when the pain intensity on the Numeric Rating Scale for pain (NRS) exceeded 3 points at rest and 4 points during movement. Pain intensity on the NRS (in points) at rest and during movement was assessed at specific time points – 15, 30, 45, 60, 120, and 240 minutes after the first dose.
RESULTS: In Group K, the initial pain intensity (on NRS, points) at rest was higher than in Group C (Me 6, Q1;Q3 – 5;7 vs. Me 5, Q1;Q3 – 5;6, respectively, p = 0.038). While the median values of initial pain intensity during movement were similar between the groups (7 points), the interquartile range was higher in Group K (Q1;Q3 – 6;8 in Group K vs. Q1;Q3 – 6;7 in Group C, p = 0.045). Lower pain values were recorded in Group C at rest at 45 and 60 minutes (p = 0.005 and p = 0.008, respectively) and during movement at 30 minutes (p = 0.036).
CONCLUSIONS: The combination of tyrosyl-D-arginyl-phenylalanyl-glycine amide with regional perioperative blockades is the optimal method for managing acute pain in the early postoperative period in patients who have undergone complex and traumatic oncological surgical interventions.
The principle of entity equality of the federation as a basis for regulating inter-ethnic relations
Authors: Gaunova Zhanna A. , Pomazanskiy Andrey E.
Published: January 2025

The article discusses the purpose and normative potential of the constitutional principle of equality of entities of the federation for the purposes of legal regulation of inter-ethnic relations in the Russian Federation. In combination with other constitutional provisions and principles, it provides constitutional and legal influence on the field of inter-ethnic relations. At the same time, the principle under consideration is a unique example of a legal solution in the field of federal and inter-ethnic relations, since it is applied to a mixed-type federation.
It is emphasized that the equality of entities of the Russian Federation is implemented both through the application of provisions directly formulated in the text of the Constitution of the Russian Federation and based on the interpretative activity of the Constitutional Court of the Russian Federation.
The study proves the dichotomy of the constitutional principle under consideration, which implies the simultaneous existence and interaction of the institutional and substantial components. Each of the components has its own purpose, collectively ensuring the proper balance between normative stability and the dynamics of legal regulation of inter-ethnic relations.
Under conditions of the achieved stability of the architecture of federal relations in the Russian Federation at the current stage, the dynamics of regulation of inter-ethnic relations is ensured through the implementation of powers by the entities of the Russian Federation on subjects of joint jurisdiction. The main focus is on solving such issues as the implementation of state national policy on the territory of the Russian Federation entity, the protection and development of the languages of the peoples of Russia, and maintaining ethno-cultural diversity for the purposes of training, education, and creativity.
The authors identified a tendency towards the normative adoption of the constitutional principle of equality of entities for the purposes of regulating inter-ethnic relations through rule-making by the entities of the Russian Federation using the example of the development of the regional identity foundations.
Establishment agreement and decision on a business entity foundation: problems of correlation
Authors: Minakova Irina R.
Published: January 2025

The article provides a comparative analysis of the establishment agreement and the decision on foundation, reveals their legal nature, and provides recommendations for changing the legislation in terms of the content of these documents.
Right of emission in the Russian law system
Authors: Karaseva Marina V.
Published: January 2025

The article examines the concept, structure, content, and place of right of emission in the system of Russian law. It is emphasized that right of emission is not a legal and regulatory, or a doctrinal concept. In essence, its content is associated with such phenomena as state sovereignty and, accordingly, the sovereign rights of the state. Therefore the conceptual approach to defining the boundaries of the right of emission should be based on understanding that the right of emission is the exclusive right of the state as an entity of power, which implements it based on its own imperative regulations, primarily general legal norms of a declarative, fundamental nature, or through power relations of a public rather than private nature. Accordingly, the right of emission cannot include accompanying institutions, namely cash circulation and cashless transfers as such. However it is obvious that the structure of the right of emission should include norms establishing the organization of cash circulation and the organization of cashless transfers.
The article provides a systematic interpretation of Article 75 of the Constitution of the Russian Federation and a number of articles of the Federal Law “On the Central Bank (Bank of Russia)”. It is concluded that the right of emission is primarily the currency issue right. It includes five blocks of legal norms which include those establishing 1) the monetary unit of the Russian Federation; 2) the currency issue (banknotes and coins); 3) the organization of cash circulation; 4) the redemption of banknotes and coins from circulation; 5) the provision of banknotes and coins and the protection of stability of the ruble. In addition, the right of emission includes the institution of organizing cashless transfers which constitutes the block 6 of the right of emission norms, which includes those establishing the rules, forms, and standards of cashless transfers.
In general, the right of emission in the Russian legal system represents a complex inter-branch legal community consisting of the norms of financial, civil, and criminal law.
Potential Benefits of Seismic Monitoring for Ground-Shaking Estimation and Loss Assessment
Authors: Silva Vitor , Wald David , Taherian Amir
Published: January 2025

Seismic networks are fundamental to compute ground shaking in regions affected by destructive events, which can then be used for damage and loss assessment. Ground-motion data recordings can be used to estimate the event bias (or interevent residual) for one or multiple ground-motion models, as well as to condition the ground-shaking estimation process to reduce the intraevent residuals at sites near seismic stations. We evaluate how the error in the estimation of the event bias and ground shaking for a set of target sites can be reduced by incorporating an increasing number of seismic stations, using recordings from the 1999 M 7.7 Chi-Chi, Taiwan, earthquake and a large set of ground-motion fields for Taiwan using stochastic simulations. Then, we evaluate how the incorporation of data from seismic stations in the estimation of several impact metrics (i.e., economic losses, collapsed buildings, and fatalities) can reduce both the bias and the uncertainty, using the district of Lisbon (Portugal) as a case study. The results from this study indicate that the error in the estimation of the impact metrics can be reduced by one order of magnitude if at least 10 stations are considered, especially if the configuration of the seismic network considers the location of vulnerable buildings or the spatial distribution of earthquake risk.
Professional Development from the Perspective of Kindergarten Teachers in the Czech Republic
Authors: Fodorová Karin
Published: January 2025

The paper focuses on the professional development of kindergarten teachers in the Czech Republic, presenting the results of a research survey conducted between April and September 2023. The study examines teachers’ motives for further education, available professional development opportunities and expectations related to the application of newly acquired knowledge in the innovation of the educational process in kindergartens, taking into account current changes in educational needs. The main aim of the research was to identify the educational needs of female teachers in the areas of child education, management and personal development. The qualitative research was conducted using a non-standardized interview method, which provided insight into the reasons and conditions of teachers’ professional development, as well as their opportunities to apply newly acquired skills in practice. The results were compared with similar research from 2017–2020. In particular, digital technologies and the desire to “keep up with the times” were identified as new learning needs. Teachers also expressed a lack of recognition of their professional work by parents and the public, which they perceived as a significant gap in practice.
Factors to Success in Life as Perceived by Ukrainian War Refugees
Authors: Łączek Tomasz
Published: January 2025

This paper is to present the results of the research on how Ukrainian war refugees perceive the category of success in life. The information obtained shed some light on how the respondents understand success in life and which factors, in their opinion, contribute to achieving it. Additionally, the results unveil their opinions and beliefs regarding their own success in life and whether they believe achieving life success makes people happy. The full-scale war that has been ravaging Ukraine since February 24, 2022 has forced a significant Ukrainian population out of the borders of their own country. Fearing for their life and safety, most of them took temporary shelter in Poland. Scientific studies with Ukrainian refugees as participants are not something that scholars engage in frequently. There are many reasons for that, and the most important is the fact that a suitable and willing group of participants is hard to come by. However, researching this population has a very important social dimension, especially from the educational and psychological perspective, because the majority of Ukrainian refugees have been arriving in Poland with minor children, who are then enrolled in the Polish school system, are cared for by Polish teachers, and participate in Polish educational, socialisation, and adaptation processes. That is why, it is crucial to consistently investigate the refugees’ opinions on their personal and social life. Teachers are a particularly important group of readers who might benefit from this paper. It is them who are predominantly responsible for the processes taking place in the educational domain. Due to the vast numbers of refugee children and students from Ukraine taught in Polish kindergartens and schools, researching the topic of success and self-fulfilment factors may increase the effectiveness of teaching, upbringing, and care in educational institutions.
¿Es posible reparar el cerebro?
Authors: Fariñas Isabel
Published: January 2025

El cerebro humano, con su intrincada red de 86.000 millones de neuronas y trillones de contactos sinápticos entre ellas, es el órgano más complejo de nuestro cuerpo. Este sofisticado órgano es la base de nuestra identidad, coordina funciones vitales, nos permite razonar y nos da la capacidad de adaptarnos a un mundo en constante cambio. Sin embargo, también es sorprendentemente vulnerable a daños. Lesiones traumáticas, enfermedades neurodegenerativas y el envejecimiento pueden afectar su funcionamiento, causando pérdidas de memoria, déficits motores y cambios en nuestra personalidad. Durante décadas, se consideró que las neuronas del cerebro adulto no podían regenerarse y que cualquier daño era permanente. Descubrimientos recientes han demostrado que el cerebro posee una notable capacidad de adaptación y reorganización a lo largo de la vida, pero está en discusión qué posibilidades hay para su reparación cuando impactauna enfermedad neurodegenerativa que causa la muerte de innumerables neuronas.Este artículo explora los avances científicos que pueden acercarnos a terapiasregenerativas en el sistema nervioso, como son la reprogramación celulary la neurogénesis adulta. Las posibilidades son aún remotas, pero las ideas defuturo inspiran algunos de los trabajos en la investigación fundamental actual.
La arena como recurso
Authors: Fernández de Monje June , Colmenero Hidalgo Elena , Cruz Martínez Juncal Altagracia
Published: January 2025

A partir de mediados del siglo XX, motivado por el aumento exponencial de la población urbana mundial, el consumo de arena y grava para construcción ha experimentado un crecimiento más acelerado y a mayor escala que cualquier otro grupo de recursos. La arena constituye uno de los recursos básicos de lasociedad actual, al ser el principal componente del hormigón con el que se construyen infraestructuras y proyectos de gran envergadura. Sin embargo, es un recurso cada vez más limitado. La extracción descontrolada a nivel mundial pone en evidencia los efectos significativos de su explotación sobre el medio ambiente y la sociedad. Mediante este trabajo se realiza un análisis integral de dicha problemática a través de una revisión de fuentes bibliográficas y se plantean cuatro líneas principales de acciones para paliar el daño ambiental derivado de la explotación de este recurso. La gravedad de los impactos  estudiados subraya la urgente necesidad de actuación de los poderes políticos frente a la crisis de escasez de la arena, así como la necesidad de establecer políticas restrictivas para regular su extracción.
Tras los rastros del lobo ibérico
Authors: Mallo Robla María
Published: January 2025

Este trabajo analiza la dieta del lobo ibérico en los alrededores de la ciudad de León (Castilla y León, España), cuantificando el consumo de presas silvestres y animales domésticos por parte de la especie. Se busca describir la importancia de cada presa, comparar los datos con los del año anterior para la misma zona de estudio y comprender los componentes temporales y espaciales del marcaje territorial del lobo. El estudio se realizó en zonas humanizadas cercanas a León mediante cuatro recorridos de muestreo. Un equipo de siete personas recolectó excrementos de lobo cada 15 días entre noviembre de 2023 y abril de 2024. Se siguió un protocolo estandarizado, que incluía la identificación preliminar de pelos en el excremento, fotografías georreferenciadas y recolección parcial de los excrementos para la posterior identificación de las presas presentes en los mismos. Los resultados más relevantes en relación con la dieta apuntan al consumo preferente de jabalíes y corzos, con una presencia pequeña de animales domésticos. Por otro lado, los patrones de marcaje territorial mostraron variaciones estacionales y espaciales, con una tendencia a utilizar los cruces de caminos como puntos estratégicos para la deposición de excrementos. Se resalta además la importancia de comprender el comportamiento territorial y la ecología trófica del lobo en un ambiente humanizado, como información básica para la gestión de la especie.
Biomarkers of resistance to anti-EGFR therapy in patients with left-sided colorectal cancer: a retrospective NGS analysis
Authors: Lebedeva A. A. , Byakhova M. M. , Pokataev I. A. , Antonova T. G. , Ivanov M. V. , Semenova A. B. , Makiev G. G. , Kravchuk D. A. , Evdokimov V. I , Bolshakova E. A , Stativko O. A. , Feoktistova P. S. , Ignateva M. A. , Grigoreva T.  V. , Kavun A. I. , Belova E. V. , Veselovskii E. M. , Mileyko V. A. , Tryakin A. A. , Fedyanin M. Yu. , Galkin V.  N.
Published: January 2025

Background: Routine analysis of KRAS, NRAS, BRAF V600 mutations, as well as MSI and HER2 guides treatment selection in colorectal cancer (CRC). Recent findings from the PRESSING and PARADIGM trials have demonstrated that the negative hyperselection of patients based on the results of comprehensive genomic profiling results in better treatment outcomes following anti-EGFR therapy. Study objective: The study aimed to retrospectively analyze the occurrence of alterations associated with potential resistance in samples from CRC patients treated with anti-EGFR therapy.

Materials and methods: Patients with confirmed left-sided CRC treated with anti-EGFR therapy due to the lack of RAS / BRAFV600 mutations as per routine PCR were included in the study. FFPE samples were analyzed via NGS (Solo-test Atlas Pro, 38 genes, MSI). Samples determined as RAS / BRAFV600positive by NGS were validated with PCR.

Results: A total of 111 samples were analyzed via NGS. A total of 172 alterations in 17 genes were found; alterations in any of the genes covered by the panel were found in 96 (86.5 %) samples. The variant allele frequency ranged 1.3–93.0 %. NGS identified 29 (26.1 %) samples with KRAS (n = 24), NRAS (n = 3) or BRAF p. V600E (n = 4) mutations. Confirmatory PCR testing of 16 RAS / BRAF p. V600E-positive samples resulted in 100 % agreement with NGS. Among RAS / BRAFV600negative samples, 10 (9 %) samples harbored other alterations (ERBB2 amplification, n = 3; PIK3CA, n = 2; MSI, n = 1; BRAF class II mutation, n = 1; ERBB3, n = 1). A total of 11 samples harbored more than 1 alterations associated with potential resistance. BRAF class II / III mutations were found in 4 samples, PIK3CA mutations — in 17 (15.3 %) samples (of those, 5 samples harbored mutations in exon 21).

Conclusions: The results of this retrospective analysis demonstrate that a high frequency of false-positive routine PCR results may lead to incorrect indication of anti-EGFR therapy in ~ 26 % cases. Analysis of alterations beyond RAS / BRAFV600 might identify an additional 9 % of patients whose tumors are potentially resistant to anti-EGFR therapy.