bluuebunny/crossref_metadata_2025 huggingface dataset:
A Clinical Model predicting the 90-Day Prognosis after Mechanical Thrombectomy in Patients with Acute Ischemic Stroke: A Retrospective Study
Authors: Huang Yu , Wu Chuyue , Du Cuiping , Lei Da , Li Li , Chen Shengli
Published: June 2024

Background and Purpose:

Mechanical Thrombectomy (MT) is the recommended
treatment for patients with an acute ischemic stroke (AIS) due to large vessel occlusion (LVO)
within 6 h after onset. However, the poor prognosis for patients with an acute great vascular occlusive
stroke after an MT, which is a common occurrence, can be attributed to an absence of
appropriate postoperative monitoring. Transcranial Doppler (TCD) ultrasound and Quantitative
Electroencephalography (QEEG) offer the advantages of rapid, convenient, and bedside examinations
compared to conventional imaging techniques.

Objective:

In the current study, we analyzed the predictive performance of clinical factors, TCD
ultrasound, and QEEG for the prognosis of patients with an AIS due to LVO 90 days after hospital
discharge.

Methods:

Methods: Patients who achieved revascularization following an MT that was performed within 6
h after the onset of AIS due to LVO were included. We used the data to build four predictive
models of prognosis and compared the predictive performance measured by the area under the
curve, sensitivity, and specificity.

Results:

Seventy-four patients were included in the study, among whom 47 had a poor prognosis
(63.5%) at the time of hospital discharge, and 45 had a poor prognosis (60.8%) 90 d after hospital
discharge. Independent predictors of poor prognosis 90 d after hospital discharge included the
following: age, National Institute of Health stroke scale (NIHSS) score at the time of hospital
admission, pulsatility index (PI) on the affected/healthy side, and relative alpha power (RAP).
The area under the receiver operating characteristic curve (AUC) was highest (0.831) among the
4 models when age was combined with NIHSS score at the time of hospital admission, TCD
parameters (diastolic velocity [VD] on the affected side and PI on the affected/healthy side), and
a QEEG parameter (e.g., RAP) for prognostic prediction. However, the AUC for the 4 predictive
models did not differ significantly (p > 0.05).

Conclusion:

Age, the NIHSS score at the time of hospital admission, TCD parameters, and a
QEEG parameter were independent predictors of prognosis 90 d after discharge in patients undergoing
MT for AIS due to LVO in the anterior circulation. The model combining the above
four parameters may be helpful for prognostic prediction in such patients.
MiR-199a-5p Deficiency Promotes Artery Restenosis in Peripheral Artery Disease by Regulating ASMCs Function via Targeting HIF-1α and E2F3
Authors: Liu Duan , Jing Yexiang , Peng Guiyan , Wei Litai , Zheng Liang , Chang Guangqi , Wang Mian
Published: June 2024

Background:

Restenosis (RS) poses a significant concern, leading to recurrent ischemia
and the potential for amputation following intraluminal angioplasty in the treatment of Peripheral
Artery Disease (PAD). Through microRNA microarray analysis, the study detected a significant
downregulation of miR-199a-5p within arterial smooth muscle cells (ASMCs) associated
with RS.

Objective:

This research aims to explore the possible function and the underlying mechanisms of
miR-199a-5p in the context of RS.

Methods:

Primary ASMCs were extracted from the femoral arteries of both healthy individuals
and patients with PAD or RS. The expression levels of miR-199a-5p were assessed using both
qRT-PCR and in situ hybridization techniques. To examine the impacts of miR-199a-5p, a series
of experiments were performed, including flow cytometry, TUNEL assay, EdU assay, CCK8 assay,
Transwell assay, and wound closure assay. A rat carotid balloon injury model was employed
to elucidate the mechanism through which miR-199a-5p mitigated neointimal hyperplasia.

Results:

MiR-199a-5p exhibited downregulation in RS patients and was predominantly expressed
within ASMCs. Elevated the expression of miR-199a-5p resulted in an inhibitory effect of proliferation
and migration in ASMCs. Immunohistochemistry and a dual-luciferase reporter assay uncovered
that RS exhibited elevated expression levels of both HIF-1α and E2F3, and they were identified
as target genes regulated by miR-199a-5p. The co-transfection of lentiviruses carrying
HIF-1α and E2F3 alongside miR-199a-5p further elucidated their role in the cellular responses mediated
by miR-199a-5p. In vivo, the delivery of miR-199a-5p via lentivirus led to the mitigation of
neointimal formation following angioplasty, achieved by targeting HIF-1α and E2F3.

Conclusion:

MiR-199a-5p exhibits promise as a prospective therapeutic target for RS since it alleviates
the condition by inhibiting the proliferation and migration of ASMCs via its regulation of
HIF-1α and E2F3.
Recent Advances in Food Hydrocolloidal System Physiochemistry
Authors: Gouda Mostafa
Published: June 2024

The recent advances in plant and animal biosystems of hydrocolloids have led scientists to
find analytical techniques to explore the scientific principles of these molecules for their functional
principles, precursors of essential pathways, and other physical and chemical processes. The current
editorial highlights the importance of applying advanced physicochemical theories and practical
examples to sustain this important innovation approach further.
Thrombosis in Myeloid Malignancies: From CHIP to AML
Authors: Borsellino Beatrice , Bravo-Perez Carlos , Visconte Valeria , Guarnera Luca
Published: June 2024

The development of myeloid malignancies is a multi-step process starting from pre-malignant
stages. Large-scale studies on clonal hematopoiesis of indeterminate potential (CHIP) identified
this condition as a risk factor for developing hematologic malignancies, in particular
myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). In parallel, CHIP was
found to confer an enhanced thrombotic risk, in particular for cardiovascular diseases. In a similar
fashion, in recent years, alongside their life-threatening features, increasing attention has been
drawn toward thrombotic complications in myeloid malignancies. Thus, the purpose of this review
is to gather a growing body of evidence on incidence, pathogenesis and clinical impact of
thrombosis in myeloid malignancies at every step of malignant progression, from CHIP to AML.
An Overview of the Degradation and Removal of Pesticide Residues from
Water and Agricultural Runoff using Nanoparticles and Nanocomposites
Authors: Sani Mahadi Danjuma , Abbaraju V.D.N.Kumar , Venugopal Nutulapati V.S. , Kura Nura Umar
Published: June 2024

:

A high percentage of the applied chemicals on farmlands find their way into the water
bodies and groundwater through agricultural runoff and leaching/percolation. Therefore, multiple
remediation techniques need to be employed to deter the menace of pesticide residue contamination.
Therefore, this review aimed to compute the most suitable degradation conditions for the removal of
pesticide residue from water and agricultural runoff using nanomaterials. The review touches on the
aspect of adsorption and photocatalytic degradation methods using nanomaterials and the most prominent factors that affect the degradation process. Information from recently published articles, book
chapters, and conference proceedings were carefully studied and analyzed. It was revealed that heterogeneous photocatalysis shows the capability of complete mineralization of organic pollutants
under optimum experimental conditions. Moreover, it is crucial to consider experimental conditions
that could be applicable in the field to achieve a better result. It has been observed that integrating
nanoremediation with other degradation methods to create a hybrid technique may play a crucial role
in removing pesticide residues from agricultural runoff. However, the detrimental effects of the nanomaterials if any on the environmental matrices need to be taken under consideration to avoid the
menace similar to plastic pollution as a result of extensive production and application of nanomaterials.
Design, Synthesis, and Evaluation of Lipoyl Ester Conjugated Star PLGA
for Sustained Drug Delivery Systems
Authors: Singh Akanksha , Gupta Chandan , Godse Shrikant , Athawale Rajani
Published: June 2024

Background:

Poly(lactic-co-glycolic acid) (PLGA), an FDA-approved copolymer, is
widely recognized for its biocompatibility, biodegradability, and versatility in drug delivery systems.
Despite its advantages, challenges, such as poor drug loading and burst release, motivate
the exploration of innovative modifications. The current research aimed to modify the linear
PLGA to lipoyl ester terminated star PLGA polymer to minimize initial burst release by increasing
the molecular weight and fabricate risperidone-loaded microspheres.

Methods:

In this study, we have presented a novel approach involving the synthesis of star
PLGA through the direct melt polycondensation of PLGA with pentaerythritol, followed by conjugation
with lipoic acid to form lipoyl ester terminated star PLGA. Structural confirmation was
done by Fourier Transform Infrared spectroscopy (FT-IR), proton Nuclear Magnetic Resonance
(1H-NMR), and Gel Permeation Chromatography (GPC). Microspheres were fabricated from
lipoyl ester terminated star PLGA and characterized for their particle size and surface morphology
by Scanning Electron Microscopy (SEM) and in vitro drug release by dialysis bag method

Results:

The results of the study have indicated successful conjugation of lipoic acid to star
PLGA forming lipoyl ester terminated star PLGA, as confirmed by FT-IR, 1H-NMR, and GPC
analyses. Microspheres developed from the synthesized polymer exhibited particle sizes ranging
from 4.64 μm to 11.7 μm and demonstrated sustained drug delivery, with 99.8% release over 45
d, in contrast to the plain drug that achieved complete dissolution within 3 h.

Conclusion:

The resulting material has demonstrated unique bioresponsive and multifunctional
properties, with evidence of successful synthesis provided through comprehensive characterization
techniques, and suitability for the fabrication of microspheres for sustained drug delivery
systems.
Beyond Pharmaceuticals: Harnessing the Potential of Plant-based Compounds for Anti-inflammatory Therapy
Authors: Mittal Vishnu , Sharma Anjali
Published: June 2024

:

A complicated biological reaction of vascular tissues to damaging stimuli like infections,
harmed cells, or irritants is called inflammation. Symptoms include redness, inflamed joints,
stiffness, discomfort in the joints, and loss of joint function. NSAIDs are frequently used to treat
inflammation. Sadly, these drugs raise the possibility of blood clots, which can result in heart attacks
and strokes. Consequently, there is ongoing research focusing on developing potent anti-inflammatory
drugs using natural ingredients. Natural products, due to their diverse chemical composition,
offer a rich source for the development of novel medications. The treatment of various inflammation-
related disorders heavily relies on a natural substance derived from medicinal plants.
The objective of the present study is to assemble information on potential parts of the plants or
phytochemicals derived from medicinal plants used on inflammatory models, employing state-ofthe-
art scientific methodologies. In this study, state-of-the-art scientific methodologies are utilized
to investigate the effects of phytochemicals derived from medicinal plants. Relevant data is collected,
focusing on the examination of these phytochemicals in experimental models of inflammation.
The study aims to collect thorough data on potential plant parts or promising phytochemicals derived
from medicinal plants that have been evaluated using advanced scientific techniques in the
realm of inflammation models. This compilation will offer valuable insights into their potential as
anti-inflammatory agents. The findings have the potential to contribute to the development of new
and improved anti-inflammatory medications with fewer or no adverse effects compared to current
treatments. While many of these studies hold academic interest only a few are accepted into
clinical trials. Numerous phytoconstituents have been identified for exhibiting diverse pharmacological
actions.
Current Therapeutic Strategies for SoilTransmitted Helminthiasis
Authors: Arya Ashwani , Nishal Suchitra , Kadian Renu , Dhall Manish
Published: June 2024

Soil-transmitted helminths [STH] are described as neglected tropical
disorders (NTDS) since these impose terrific distress and disability, nevertheless, they
can be eradicated or controlled. The pervasiveness of STH is more usual in
rustic/bucolic areas than in city areas. STH signifies the worms present in the intestine
provoking infection in humans and are transmitted/ conveyed via unhygienic/ dirty soil.
“Helminth” denotes a parasitic worm and the causative agents/ chief species that can
harm humans are the hookworms (Ancylostomaduodenale and Necatoramericanus),
whipworms (Trichuristrichiura) and roundworms (Ascarislumbricoides). Various
features namely, Hypersensitivity reaction (Type -1), the response of defective Th2,
mucosal inflammation, volvulus, obstruction of small bowel and intussusception, blood
loss in the mucosa, anaemia, etc. are involved in the pathophysiology of STH. To
control mortality and morbidity, WHO has recommended population-based, specific,
and target-based approaches. The medications recommended by WHO are
Albendazole, Levamisole, Mebendazole, and Pyrantelpamoate as a single dose.
Preclinical studies are being carried out on the ayurvedic and herbal treatments
employing medicinal plants for STH infections as these are compatible with the body
and have fewer side effects. The infection is now considered a major public health
issue; the major role played by poor sanitation and hygiene in addition to this is certain
environmental conditions. Thus, soil-conveyed helminth infections have a primary
influence on socio-economic progress and advancement of society where occurrence
rates are higher as such acquired infections influence the performance of adults to do
work properly and provoke absenteeism amongst school-going children.
Nematode Problems in Ornamental Plants
Authors: Khan Mujeebur Rahman , Haque Ziaul , Akram Mohammad , Ansari M. Shahid Anwar
Published: June 2024

Nematode infestation in ornamental crops affects the quantity and quality of
flower yield, reducing flower size, total flower number, and the productive life of the
plant. The most devastating nematode genera affecting ornamental crops are root-knot
nematode, Meloidogyne species; foliar nematode, Aphelenchoides species stem and
bulb nematode, Ditylenchus species and root-lesion nematode Pratylenchus species.
Nematode management in ornamental plants is difficult for many reasons, but
practising nematode-free planting material, using cultural methods like a nursery or
field cleanliness and application of nematicides can reduce the nematode populations.
Hot water treatment of planting material is effective in eliminating nematode infection
in vegetatively propagative materials. The use of resistant cultivars and biocontrol
agents may also limit nematode damage in the plants. In this chapter, the problem of
nematodes in important ornamental plants viz., Chrysanthemum, tuberose, crossandra,
orchid, anthurium, gladiolus, gerbera, jasmine, lilies, narcissus, tulip and hyacinth are
described, and information on general approaches of nematode management are
discussed.
Major Diseases of Aromatic Plants
Authors: Samad Abdus , Saeed Sabiha
Published: June 2024

Aromatic plants provide the chief raw materials for cosmetics, perfumery
and food industries. In recent years, with the rising need for therapeutic herbal
medicines, attention towards aromatic plants has increased. Because of inherent and
remedial pharmacological characteristics, aromatic plants are also exploited as natural
medicines, and are mainly used for the extraction of essential oils, which have
tremendous application in various industries. Aromatic plants become infested with
many diseases that cause degradation of the quality and quantity of the required
economic product. Considerable success has been achieved in managing the disease
through cultural practices and biological and chemical control. The present chapter
focuses on major diseases caused by fungi, viruses and bacteria threatening the
bioactive potential, biomass, yield and various plant products of important aromatic
plants, viz., basil (Ocimum spp.), citronella (Cymbopogon spp.), eucalyptus (Eucalyptus
spp.), Geranium (Geranium spp.), mint (Mentha spp.), rose (Rosa spp.), orchid (Orchis
spp.), tuberose (Polianthes tuberosa), etc. To enhance metabolite productive potential
and raw material quality, necessary strategies of management for diseases have been
defined, which are presented in the chapter.
Diseases of Tuberous Medicinal Plants
Authors: Zuhaib Mohammad , Singh Archana
Published: June 2024

Tuberous medicinal plants (TMP) are an important group of plants in which
roots are modified into tubers and used for medicinal purposes. Many TMPs viz.,
Ashwagandha (Withania somnifera), safed musli (Chlorophytum borolivianum),
Patarchur (Coleus forskohlii), asparagus (Asparagus adscendens), turmeric (Curcuma
longa), Holostemma adakodien, Typhonium trilobatu, etc. are currently used in the
preparation of stimulants, tonics, carminatives and expectorants. Plant diseases
especially those caused by fungi, bacteria and viruses pose a serious threat to the
profitable cultivation of tuberous medicinal plants. Important diseases of tuberous
medicinal plants include root rot, wilt, tuber rot, rhizome-rot etc, which are mainly
caused by soil-borne pathogens such as Fusarium, Verticillium, Sclerotium,
Rhizoctonia and Pythium species. Growers generally use fungicides/pesticides to
control these diseases. However, chemical residues in the plant tissue resulting from
pesticide application make TMP medicine unsafe for human health. Biological control
using antagonistic fungi and bacteria is a good substitute for chemical pesticides. In
this chapter, we present an elaborate description of the important diseases of TMPs
along with their sustainable management options.
Polymyalgia Rheumatica Presenting as Nocturnal Pyrexia of Unknown Origin: A Case Report
Authors: Butt Nauman Ismat , Ghoauri Muhammad Sohail Ajmal , Riaz Muhammad Waseem , Aiman
Published: June 2024

Background. Polymyalgia rheumatica (PMR) is a rheumatic disorder characterized by musculoskeletal stiffness and pain, primarily affecting the shoulder, neck, and hip areas. It is more common in females, with the peak incidence usually after the age of 70.
Case Report. A 74-year-old man presented with a two-month history of low-grade nocturnal fever up to 100oF (37.7oC) which did not respond to multiple courses of antibiotics. There was unintentional weight loss of 5 kg and mild shoulder stiffness. The patient had a history of Type 2 diabetes mellitus treated with 34 units of insulin (Humulin 70/30) daily and active smoking of 40 pack-years. On examination, mild tenderness of both shoulder girdle muscles and discomfort on external rotation were noted. The initial blood work-up revealed raised erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. Serologies for syphilis, human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) were negative. Given the negative results of infective and malignancy screening, along with raised inflammatory markers and mild shoulder stiffness, a diagnosis of PMR was made and a trial of prednisolone was initiated, resulting in the resolution of symptoms.
Conclusions. The present case report highlights the importance of thoroughly investigating all differential diagnoses of pyrexia of unknown origin, regardless of the patient’s ethnic origin, to facilitate timely diagnosis.
Eficacia de la Sentencia T-622/16 y derechos bioculturales
Authors: Moreno Cordoba Laura Johana , Vergara Mosquera Gilbert Stein
Published: June 2024

Introducción: Efectividad del estado colombiano, instituciones y comunidades en la defensa, promoción y protección de los derechos bioculturales de las comunidades situadas en la cuenca del rio Atrato, de acuerdo a las ordenes de la corte constitucional en la sentencia T-622-2016. Objetivo: este artículo fue elaborado con el propósito de examinar la eficacia de la sentencia T-622-2016 y sostenibilidad de los derechos bioculturales de las comunidades afrocolombianas del chocó, y el impacto en la calidad de vida de las comunidades rivereñas. Metodología: se eligió el método cualitativo como perspectiva de estudio, con respecto a la materialización de la sentencia t-622-2016 y para su elaboración se realizaron estudios etnográficos, entrevistas a miembros de la comunidad y cuerpo colegiado de guardianes del rio Atrato. Resultados: con base en el estudio realizado se infiere que las ordenes de la corte constitucional en aras de garantizar la protección de los derechos bioculturales y preservación del rio Atrato, no han tenido consecuencias reales en la vida practica de estas comunidades étnicas. conclusiones: para concluir, el abandono estatal y la inoperancia institucional, atentan contra la sostenibilidad de los derechos bioculturales de las comunidades del departamento del chocó e impactan en su calidad de vida.
Development of Blended Learning-Based Family Institution Partnership Model in Stimulating Early Children's Development
Authors: Rahma Rezka Arina , Rahmania Lidya Amalia , Sari Zihan Novita
Published: June 2024

This study aimed to develop a partnership model between Early Childhood Education (PAUD) institutions and families based on blended learning and to test the partnership model's effectiveness in stimulating children's development. The research and development (RD) method is used in this research. This study develops a blended learning-based partnership model between the Institute and the family and tests the model's effectiveness in stimulating children's development. The research subjects were principals, teachers, administrators, and parents at TPA Melati Dharma Wanita Persatuan UM. The results showed that the factual partnership model becomes a reference in developing the school's partnership model with parents through the blended learning method. This factual model includes planning, organizing, implementing, and evaluating the school's partnership program with parents. Through the blended learning method, the school partnership model with parents can help TPA Melati UM develop and implement a school partnership program with parents, which must be adapted to school conditions. It is the objective of School-Based Quality Improvement Management (Manajemen Peningkatan Mutu Berbasis Sekolah-MPMBS). Factors that influence the effectiveness of the blended learning model include the basic requirements of the model, the profile, roles and characteristics of the school, and monitoring and evaluation.
Women’s Participation in Cultural Tourism Based Community Empowerment
Authors: Hasdiani Tanisa , Mulyono Sungkowo Edy , Abimbowo Yusuff Olatunji
Published: June 2024

Kampung Batik is one of the cultural tourism destinations and has been the largest Batik producer in Semarang city since the 18th century. Most of the population consists of women who are actively involved in Batik cultural activities. The research aims to describe the stages, the forms, and the impact of women’s participation in community empowerment. The study was designed with a descriptive qualitative approach involving three female members, including the Tourism Assistance Community of Kampoeng Djadhoel chairman, the Neighborhood Head of Kampung Batik, and the Kampung Batik community. Data were collected through participatory observation, interviews, and documentation. Data validity testing was carried out using triangulation of sources and techniques. The stages of data analysis were data collection, data reduction, data presentation, and conclusion drawing. The results showed that the stages of women’s participation included decision-making, activity implementation, monitoring and evaluation, and utilization of development results. The positive impact of women’s participation is increased employment, income, and skills; the negative effect is the problem arising from Batik waste management. This research can be a reference for the government, society, and women to improve women’s welfare through empowerment.
Finansjalizacja regionów – czy o finansjalizacji można mówić w ujęciu regionalnym?
Authors: Gemzik-Salwach Agata
Published: June 2024

Finansjalizacja oznacza rosnącą rolę motywów finansowych, rynków, podmiotów oraz instytucji w transakcjach zachodzących w gospodarce krajowej i międzynarodowej. W artykule zostały zawarte rozważania na temat tego, czy finansjalizacja może mieć charakter regionalny. Jego celem było uzyskanie odpowiedzi na to pytanie i określenie przydatności tej wiedzy. Na podstawie przeprowadzonego przeglądu literatury stwierdzono, że istnieją badania skutków finansjalizacji odnoszące się do regionów, przy czym pojęcie „regionu” jest tu różnie rozumiane. Może być ono traktowane jako część świata, gospodarka danego kraju lub mniejszy obszar, mieszczący się w ramach jednego kraju. W stosunku do każdego z tych znaczeń regionu badania empiryczne dotyczące finansjalizacji wymagają zastosowania innego sposobu jej pomiaru. Niemniej jednak zawsze wskazują one na istniejące różnice pomiędzy, różnie określonymi, regionami. Proces finansjalizacji może przebiegać zupełnie odmiennie w różnych regionach, a jego skutki mogą być zarówno pozytywne, jak i negatywne. Przeprowadzone rozważania doprowadziły do wniosku, że ważna jest znajomość dotycząca stopnia nasycenia finansjalizacją w regionie. Tam, gdzie finansjalizacja jest jeszcze w niewielkim stopniu rozwinięta jej dalszy rozrost będzie skutkował korzystnymi konsekwencjami, natomiast w regionach o wysokim stopniu finansjalizacji można oczekiwać jej negatywnych skutków. Znajomość poziomu finansjalizacji w ujęciu regionalnym pozwala na określenie, w których regionach należy finansjalizację wspierać, a w których hamować. Słowa kluczowe: finansjalizacja, ujęcie regionalne, wzrost gospodarczy
Element szczególny w otoczeniu – interakcje Krajobraz kulturowy, jego niezbywalne elementy – skansen w Nowogrodzie
Authors: Werner Barbara
Published: June 2024

Celem artykułu jest pokazanie złożoności problematyki waloryzacji miejsc zabytkowych i odpowiedzi na nurtujące pytanie: czy w XXI w. w wystarczającym stopniu zauważa się rolę „elementu szczególnego w otoczeniu” i jaką rolę pełnią różne organizacje, w tym pozarządowe, jak np. ICOMOS ? Zdefiniowane jest pojęcie krajobrazu kulturowego – począwszy od ujęcia prawnego (ustawa) poprzez definicje różnorodnych autorów. Jest to autorska refleksja dotycząca roli człowieka w kształtowaniu krajobrazu, jego ujarzmianiu, zawłaszczaniu, ale także chęci i próbie ochrony. Jedną z form ochrony krajobrazu kulturowego są skanseny, które jako forma samoistna pojawiły się pod koniec XIX w. w Szwecji. Czy Szwedzi już wówczas mieli na względzie ochronę kultury i natury ? Tak ! Warto zwrócić uwagę na to, że w tym czasie w Polsce było szczególne wyczulenie na piękno krajobrazu rodzimego i niebagatelną rolę spełniał nurt tzw. „swojszczyzny”, wraz z rozpowszechnionym malarstwem pejzażowym. Ten bardzo szczególny element, także w polskim krajobrazie, zarejestrowany nieco później – (w przypadku Skansenu w Nowogrodzie w 1927 r.) przeszedł do historii polskiego muzealnictwa. Słowa kluczowe: cywilizacja, kultura, krajobraz kulturowy, skanseny
Chromosome 7 Isodisomy in a Child with Silver-Russell Síndrome
Authors: Méndez-Rosado Luis A. , Vaglio Alicia , Lardoeyt- Ferrer Roberto , Candimba-Sebastiao Albertino , Pupo-Balboa Judith , Iourov Ivan Y. , Esperon Alejandro
Published: June 2024

Silver-Rusell syndrome is a rare genetic disease. There is evidence that the genetic causes of the disorder are heterogeneous, with predominant alterations in the imprinted regions of chromosomes 11 and 7, in addition to other genomic alterations, such as chromosomal structural aberrations, single nucleotide polymorphisms, copy number variations, and small insertions and deletions. The most prevalent clinical manifestations include prenatal and postnatal growth retardation, dysmorphic features, and feeding difficulties. We present a case of a 4-year-old boy with phenotypic features consistent with Silver-Russell syndrome. The sample was subjected to conventional karyotyping analysis. The analysis was also conducted using the SALSA MLPA Probemix ME032-A1 UDP7-UDP14 and Applied Biosystems CytoScan 750K Suite. MS-MLPA analysis revealed the presence of hypermethylation in the GRB-10 and MEST genes on chromosome 7. SNP-array analysis revealed a loss of heterozygosity (LOH) at 7q11.22q31.1 (38.7 Mb). The methylation of the genes involved in this epigenetic event, in conjunction with LOH and the clinical characterization of this child, indicates that the origin of the disease is due to an isodisomy of maternal chromosome 7. This report of a child who exhibits the clinical characteristics of SRS and presents a UPD of chromosome 7, most likely originating from the mother, once again demonstrates the involvement of these genes in SRS despite the incomplete understanding of the underlying mechanism. A multidisciplinary strategy has been proposed for the follow-up and treatment of this disease according to its etiology in the proband.
Exploring the Use of a Length AI Algorithm to Estimate Children’s Length from Smartphone Images in a Real-World Setting: Algorithm Development and Usability Study (Preprint)
Authors: Chua Mei Chien , Hadimaja Matthew , Wong Jill , Mukherjee Sankha Subhra , Foussat Agathe , Chan Daniel , Nandal Umesh , Yap Fabian
Published: June 2024

BACKGROUND

Length measurement in young children younger than 18 months is important for monitoring growth and development. Accurate length measurement requires proper equipment, standardized methods, and trained personnel. In addition, length measurement requires young children’s cooperation, making it particularly challenging during infancy and toddlerhood.

OBJECTIVE

This study aimed to develop a length artificial intelligence (LAI) algorithm to aid users in determining recumbent length conveniently from smartphone images and explore its performance and suitability for personal and clinical use.

METHODS

This proof-of-concept study in healthy children (aged 0-18 months) was performed at KK Women’s and Children’s Hospital, Singapore, from November 2021 to March 2022. Smartphone images were taken by parents and investigators. Standardized length-board measurements were taken by trained investigators. Performance was evaluated by comparing the tool’s image-based length estimations with length-board measurements (bias [mean error, mean difference between measured and predicted length]; absolute error [magnitude of error]). Prediction performance was evaluated on an individual-image basis and participant-averaged basis. User experience was collected through questionnaires.

RESULTS

A total of 215 participants (median age 4.4, IQR 1.9-9.7 months) were included. The tool produced a length prediction for 99.4% (2211/2224) of photos analyzed. The mean absolute error was 2.47 cm for individual image predictions and 1.77 cm for participant-averaged predictions. Investigators and parents reported no difficulties in capturing the required photos for most participants (182/215, 84.7% participants and 144/200, 72% participants, respectively).

CONCLUSIONS

The LAI algorithm is an accessible and novel way of estimating children’s length from smartphone images without the need for specialized equipment or trained personnel. The LAI algorithm’s current performance and ease of use suggest its potential for use by parents or caregivers with an accuracy approaching what is typically achieved in general clinics or community health settings. The results show that the algorithm is acceptable for use in a personal setting, serving as a proof of concept for use in clinical settings.

CLINICALTRIAL

ClinicalTrials.gov NCT05079776; https://clinicaltrials.gov/ct2/show/NCT05079776
The Influence of NCT Dream as Lemonilo Brand Ambassador on NCTZEN Purchasing Decisions (Survey of Instagram Account Followers @nct_indonesia)
Authors: Hi A. Rahman , Atmodjo Juwono Tri , Subiakto Vania Utamie , Putri Ghina Aulia
Published: June 2024

Brand Ambassador is someone chosen by the company to represent a product. NCT Dream was chosen by Lemonilo to represent their products and bring Lemonilo closer to the younger generation. The purpose of this research is to find out how much influence NCT Dream as Lemonilo's brand ambassador has on purchasing decisions for NCTZEN (survey of followers of the Instagram account @nct_indonesia). This type of research is descriptive research with quantitative methods. This research was conducted in May 2023. The number of samples in this study were 100 respondents to followers of the @nct_indonesia Instagram account, using a sampling technique, namely simple random sampling and using the S-O-R Theory (Effendy, 2003). The results of this study are seen from the t test, namely t-count> t-table (5.606> 1660) meaning that H0 is rejected and H1 is accepted besides that the R-Square in this study is 24.3% while the other 75.7% is explained by other factors. This shows that the use of NCT Dream as Lemonilo's brand ambassador for purchasing decisions for NCTZEN (Survey of Instagram account followers @nct_indonesia) is effective.
Rumi and the Paradox of Character in The Forty Rules of Love by Elif Shafak
Authors: Thundil Abel Johnson
Published: June 2024

This paper aims to study the characters in Elif Shafak’s The Forty Rules of Love in the context of Sufism. It primarily examines what Aziz and Ella represent beyond the text. Parallels are drawn between the eponymous characters, Rumi, and other mystics of the time. Sufi philosophy is studied through symbolic significance of the elements fire and water. The Christian wisdom present is also observed. Allusions to the Masnavi, Rumi’s magnum opus, is inferred to be present in the novel. Ella and Aziz grow and change. This growth is examined through the four stages of Sufism.
Modernism in Indian English Literature
Authors: Rani Manisha
Published: June 2024

Indian English literature can be specified as a literature originally written in English by authors who are Indians by birth, origin, and nationality. Diaspora is a term used to describe a group of people living in exile. Literature of the Indian Diaspora constitutes a major study of the literature and other cultural texts of the Indian Diaspora. It is a globally accepted fact that Diasporic writers set a propensity since Independence. Writing in the Diaspora occupies a distinctive place among nations and cultures. Indo-English literature emerged as an interesting outgrowth of an eventful encounter in the late eighteenth century between lively and enterprising Britain and anarchic India. In this present paper, I would like to raise two important questions: the first will concern the cultural alienation of Indian writers writing in English, usually referred to as westward impulsion, East-West encounter, or cross-cultural conflict. Alienation is a concept transplanted to Indian soil that gained currency in postwar Europe and whose roots lie deep in the Old Testament. The cultural alienation of Indian writers writing in English can be tackled from the beginning. Indian writing has absorbed at least three major currents: The Central European Aryan, the Muslim, and the British, which have had a strong and creative influence on the primary driving force. The second part deals with the identity of Indian writers writing in English as authors of English literature, which is constantly questioned. The present work tries to examine such writings, which appear as a meander of nothingness that repeats the same kind of ideas in every piece of writing, in almost all works of all writers: you can call it a negative conception, the exculpation lies in the resulting proposals; for this purpose, I would like to select some writers and their works that are noteworthy.
МЕТОД ИССЛЕДОВАНИЯ ВЗАИМНОЙ ОРИЕНТАЦИИ ПОВЕРХНОСТЕЙ ПЛАСТИН, ИЗГОТОВЛЕННЫХ ИЗ ОПТИЧЕСКИ ПРОЗРАЧНЫХ МАТЕРИАЛОВ
Authors: Султанова Г.Х. , Пракаш А.А. , Гладких Е.В. , Русаков А.А. , Корнилов Н.В. , Усеинов А.С.
Published: June 2024

В данной статье описано устройство для оперативного контроля углов наклона и углов между гранями прозрачных в диапазоне видимого излучения пластин. Рассчитан диапазон значений углов, которые позволяет измерять данная установка. Измерения и расчеты коэффициентов отражения образцов из кремния, сапфира, кварца и полиметилметакрилата, поверхности которых имеют различную шероховатость, позволили сформулировать ограничение на качество исследуемой поверхности: среднеквадратичная шероховатость не должна превышать 50 нм.
Alquimia didáctica: la interacción de docentes universitarios con la Inteligencia Artificial Generativa
Authors: Aubert Elsa , Gladkoff Lucía , Andreoli Silvia , Perillo Luciana , Cherbavaz María Cecilia
Published: June 2024

Este estudio tiene como objetivo investigar las experiencias de los profesores universitarios en su interacción con la Inteligencia Artificial Generativa (IAGen) en el marco de dos propuestas formativas que formaron parte del Ciclo de Formación Docente en Inteligencia Artificial “Iteraciones en universos mutantes”. Utilizando una metodología cualitativa interpretativa, el análisis identificó cinco categorías principales: 1) Exploración del vínculo conversacional entre docentes y entidades tecnológicas; 2) Aproximación progresiva y crítica de las iteraciones; 3) Interpelación sobre la pertinencia, la relevancia y la rigurosidad disciplinar; 4) La experimentación de dinámicas sinérgicas para el diseño de la enseñanza; y 5) La búsqueda de experiencias de aprendizaje singulares. El estudio revela la complejidad y los desafíos que enfrenta la Universidad en la construcción de conocimiento en los diferentes campos disciplinares y las reflexiones en torno al rol docente. Si bien se reconoce el potencial de estas tecnologías para complementar y agilizar ciertas tareas académicas, también se cuestiona su capacidad para captar la especificidad y el rigor del conocimiento experto, lo que desafía la integridad académica y ética en los procesos educativos. La exploración con IAGen favoreció procesos reflexivos en los docentes, que volvieron a poner en cuestión conceptos y supuestos sobre la enseñanza desde una mirada crítica.
Universidad 5.0 El futuro de la Universidad y la Alfabetización en Inteligencia Artificial
Authors: Alvarez Torres Francisco Javier , Velázquez Sagahón Francisco Javier , López Torres Gabriela Citlalli
Published: June 2024

El artículo explora la evolución de la Universidad en el contexto de la revolución tecnológica, centrándose en la Inteligencia Artificial (IA). Se destaca la importancia de la IA en la transformación de la educación superior y en la sociedad en general. La Universidad 5.0 se presenta como un modelo que no solo integra y enseña IA, sino que también promueve su alfabetización y su aplicación ética. Se discuten los desafíos y beneficios de la alfabetización en IA para estudiantes y profesores, así como las implicaciones sociales y laborales de la automatización impulsada por la IA. Además, se propone un enfoque inclusivo y colaborativo para las Universidades 5.0, donde la tecnología y la innovación se combinan con un compromiso social y ambiental. El artículo también resalta la necesidad de adaptación de las universidades tradicionales hacia este nuevo modelo educativo y ofrece recomendaciones para su transición. En resumen, la Universidad 5.0 representa una visión integral y sostenible de la educación superior en la era de la IA y las tecnologías emergentes.
modelo pedagógico percibido en la práctica educativa en el área de Tecnología e Informática en una institución educativa de Barranquilla
Authors: Herrera Pérez Jhan Carlos , Ochoa Londoño Efraín Darío , Tello Zuluaga Jefferson
Published: June 2024

El modelo pedagógico dentro de una institución educativa permite orientar los procesos de enseñanza y aprendizaje, las relaciones entre docentes y estudiantes, los contenidos, las estrategias y metodologías utilizadas, la evaluación, etc. El objetivo de esta investigación es develar los procesos de enseñanza y aprendizaje desarrollados a través de Entornos Virtuales de Enseñanza y Aprendizaje -EVEA- en el área de tecnología e informática desde la percepción de los actores pedagógicos. Para realizar esta investigación, se utilizó una metodología bajo el paradigma interpretativo, enfoque cualitativo, el método de la teoría fundamentada, la técnica de la entrevista en profundidad y como instrumento un guion de entrevista. Los resultados muestran que se presenta una coexistencia de diversos modelos pedagógicos en la práctica educativa de los docentes. Se concluye que es necesario invertir en formación docente que coadyuve a proporcionar una educación de calidad representada en estudiantes competentes, holísticos, autónomos, capaces de afrontar retos y obstáculos que les ayuden a resolver las necesidades de las sociedades actuales
Mecanismos alternos de resolución de Conflictos en Instituciones Educativas de Villanueva, La Guajira.
Authors: Blanchar Martinez Tatiana Carolina , Martinez Trujillo Nerys Esther
Published: June 2024

Los mecanismos alternos de solución de conflictos son una herramienta fundamental para la resolución de controversias de manera pacífica, por ello es fundamental abordarlo desde temprana edad con el fin de ir generando una cultura de paz que perdure en el tiempo. Este articulo presenta evidencia de los resultados de una investigación cualitativa que tuvo por propósito determinar los mecanismos alternos de resolución de conflictos utilizados por los docentes de las instituciones educativas del municipio de Villanueva, La Guajira. La metodología se abordó desde el enfoque cualitativo, guiado por el método de acción educativa, el cual permitió plantear estrategias prácticas y concretas para abordar un problema o situación específica en el ámbito educativo. En cuanto a los resultados y el análisis de los mismos, se realizaron mediante el softwareAtlas.ti 7, con una muestra no probabilística. Los hallazgos que arrojó la investigación en la aplicación de la entrevista en profundidad y los grupos focales, es la directa relación que existe entre la enseñanza de los mecanismos alternos de solución de conflictos y la manera en cómo los estudiantes resuelven sus controversias, dando lugar a que el desconocimiento en materia de conciliación y mediación permite que los estudiantes antes de acudir al diálogo recurran a agresiones físicas o verbales de manera impulsiva. Por otro lado, a través de la aplicación de instrumentos se pudo conocer la falta de implementación de estrategias de promoción y prevención de conflictos en el marco de la convivencia escolar que establece la ley 1620 del 2013.
Regulatory role of LncRNA CASC15 in malignant tumors
Authors: Shen Yujie , Xu Ying , Li Yuanfeng , Chen Zijun , Chen Zhihao , Liao Wenjing , Liu Shuai , Wu Jingchao , Yang Hong
Published: June 2024

It has been reported that long non-coding RNA (lncRNA) is closely
related to tumor development and chemotherapy resistance. Cancer
susceptibility candidate 15 (CASC15) is a cancer-related lncRNA located
on chromosome 6p22.3 which is abnormally expressed in different
malignant tumors. CASC15 is involved in a variety of biological
processes, such as cell growth, migration and invasion. Various studies
have shown that CASC15 is expected to become a novel biomarker and
therapeutic target for cancer. In this review, we summarize the
regulatory function and mechanism of CASC15 in malignant tumors, as well
as its potential value in the diagnosis and treatment of tumors.
Detection of H1N1 Influenza Virus in the Bile of a Severe Influenza Mouse Model
Authors: Liu Yan , Xu Jiuyang , Wei Cheng , Xu Yitian , Lyu Chen , Sun Mingzhi , Zheng Ying , Cao Bin
Published: June 2024

Influenza virus infection may lead to fatal complications including
multi-organ failure and sepsis. The influenza virus was detected in
various extra-pulmonary organs in autopsy studies during the 2009
pandemic. However, limited research has been conducted on the presence
of viral particle or viral components in the peripheral blood. We
established a mouse model for severe H1N1 influenza. The bile and blood
samples were collected over time and inoculated into embryonated chicken
eggs. We detected live influenza virus with plaque assay test and
negative stain with electronic microscopy in bile and blood samples in
early infection. Immunofluorescence showed influenza viral components in
the liver tissue. No live virus was isolated in the bile in mice
intragastrically administered with influenza virus, indicating that the
virus was spread from the blood stream. Targeted metabolomics analysis
of bile acid and liver tissues showed that a secondary bile acid
(3-dehydrocholic acid) was decreased after influenza H1N1 infection.
Genes related with fatty acid metabolism and bile secretion pathways
were down-regulated in liver after influenza virus infection. Our study
indicated that influenza virus viremia is present in severe influenza,
and that the liver is a target organ for influenza viral sepsis.
Reforms are urgently needed to break through the bottleneck challenges during plantation restoration
Authors: Zhao Danyang , Bi Huaxing , Liu Zehui , Guan Ning , Song Yilin
Published: June 2024

Climate change mitigation strategies that are based on nature include
artificial forests, which are being utilized in greater numbers globally
to restore environmental degradation and devastation caused by human
activities. However, a substantial expansion in the amount of plantation
forests does not guarantee the successful restoration of ecological
function. In this study, we investigated the plantation forest
restoration success by conducting field monitoring and analyzing the
function of monoculture plantations and natural secondary forests. Our
research revealed that although certain forests have successfully
restored their ecological function as anticipated, there is a disparity
between the plantation forests and the natural forests. The present
restoration of plantation forests is facing a bottleneck challenge,
where previously built forests are inefficient and are facing
degradation without a successor to take up the “next baton”. Upon
optimizing the configuration of stand factors and terrain factors, we
discovered that the ecological function of plantation forests can be
substantially enhanced. We suggest that the close-to-nature management
is urgently needed to promote the transformation of monoculture
plantations into near-natural forests.