bluuebunny/crossref_metadata_2025 huggingface dataset:
Efeito modulador da Ritalina® (metilfenidato) sobre a ação carcinogênica da doxorrubicina em Drosophila melanogaster
Authors: Santos Juliene César Dos , Silva Samuel Campos , Orsolin Priscila Capelari
Published: March 2019

Introdução: A Ritalina® (metilfenidato) é um estimulante do sistema nervoso central, derivado da anfetamina. Ficou conhecida por seu uso em crianças e adultos diagnosticados com transtornos de déficit de atenção e hiperatividade, e alternativamente para tratamento de narcolepsia, obesidade e como estimulante para estudantes. Objetivo: Avaliar o efeito carcinogênico e/ou anticarcinogênico da Ritalina®. Método: Para tanto, larvas wts+/+mwh foram tratadas com o indutor tumoral doxorrubicina (0,4 mM) e com três diferentes concentrações de Ritalina® (100; 200 e 400 μM). Resultados: Mostraram que a Ritalina® apresentou atividade anticarcinogênica, visto que houve diferença estatisticamente significativa (p<0,05) nas frequências de tumores identificados com a presença da referida substância, quando comparadas à frequência de tumores no controle positivo isolado. Conclusão: Sendo assim, é possível inferir que, nas presentes condições experimentais, a Ritalina® apresentou efeito modulador sobre danos induzidos pela doxorrubicina, reduzindo a frequência de tumores em todas as concentrações testadas em células somáticas de Drosophila melanogaster.
Application of Partial Least Squares Discriminant Analysis for Discrimination of Palm Oil
Authors: Mohd Ruah Mas Ezatul Nadia , Rasaruddin Nor Fazila , Sim Siong Fong , Jaafar Mohd Zuli
Published: March 2019

This paper outlines the application of chemometrics and pattern recognition tools to classify palm oil using Fourier Transform Mid Infrared spectroscopy (FT-MIR). FT-MIR spectroscopy is used as an effective analytical tool in order to categorise the oil into the category of unused palm oil and used palm oil for frying. The samples used in this study consist of 28 types of pure palm oil, and 28 types of frying palm oils. FT-MIR spectral was obtained in absorbance mode at the spectral range from 650 cm-1 to 4000 cm-1 using FT-MIR-ATR sample handling. The aim of this work is to develop fast method in discriminating the palm oil by implementing Partial Least Square Discriminant Analysis (PLS-DA), Leaming Vector Quantisation (LVQ) and Support Vector Machine (SVM). Raw FT-MIR spectra were subjected to Savitzky-Golay smoothing and standardised before developing the classification models. The classification model was validated by finding the value of percentage correctly classified using test set for every model in order to show which classifier provided the best classification. In order to improve the performance of the classification model, variable selection method known as /-statistic method was applied. The significant variable in developing classification model was selected through this method. The result revealed that PLS-DA classifier of the standardised data with application of t-statistic showed the best performance with highest percentage correctly classified among the classifiers.
Applying the Method of Lagrange Multipliers to Derive an Estimator for Unsampled Soil Properties
Authors: Ng Set Foong , Ch’ng Pei Eng , Chew Yee Ming , Ng Kok Shien
Published: March 2019

Soil properties are very crucial for civil engineers to differentiate one type of soil from another and to predict its mechanical behavior. However, it is not practical to measure soil properties at all the locations at a site. In this paper, an estimator is derived to estimate the unknown values for soil properties from locations where soil samples were not collected. The estimator is obtained by combining the concept of the ‘Inverse Distance Method’ into the technique of ‘Kriging’. The method of Lagrange Multipliers is applied in this paper. It is shown that the estimator derived in this paper is an unbiased estimator. The partiality of the estimator with respect to the true value is zero. Hence, the estimated value will be equal to the true value of the soil property. It is also shown that the variance between the estimator and the soil property is minimised. Hence, the distribution of this unbiased estimator with minimum variance spreads the least from the true value. With this characteristic of minimum variance unbiased estimator, a high accuracy estimation of soil property could be obtained.
Vibrational Analysis of Li1+xAlxTi2-x(PO4)3(0.0 < x < 0.5) Glass Ceramic Electrolytes Prepared by Acetic Acid­ Assisted Sol-Gel Method
Authors: Hamidi Maziidah , Mohamed Syafawati Nadiah , Raja Mustapha Raja Ibrahim Putera , Hassan Oskar Hasdinor , Yahya Muhd Zu Azhan
Published: March 2019

In this study, Li1+xAlxTi2-x(PO4)3(0.0 < x < 0.5) was prepared by acetic acid­assisted sol-gel method. The structural properties of NASICON phosphates material with chemical formula LiTi2 (PO4)3 were observed using the Fourier transform infrared spectroscopy. NASICON is a family of crystalline phosphate with a general network system consisting of PO4 tetrahedra, thus bands were assigned by vibrations contributed by basic phosphates, in the wavenumber region between 1300 cm-1 and 600 cm-1. Experimental spectra indicated that all Li1+xAlxTi2-x(PO4)3(0.0 < x < 0.5), heat treated at 600°C and 700°C for 3 hours in air, samples showed the presence of phosphate peaks with shift in frequency as Al3+ is substituted into the structure, and with increasing temperatures. Some bands broadened and overlapped causing it hard to analyze the arising bands. It however determined the existence of NASICON structure in all of the samples under study.
Kinetics Study of Membrane Anaerobic System (MAS) in Palm Oil Mill Effluent (POME) Treatment
Authors: Nour Abdurahman Hamid , Yahya Asdarina , Amirah N. F. S. , Abdul Rahman Siti Natrah , Mohammed Manshor Norasmah , Hassan Zulkafli
Published: March 2019

Increasing demands in palm oil industry resulting in the increase in production palm oil. It is then creating a major problem in disposing the waste to be treated in appropriate ways. The governments are forced to look for alternative technology for the palm oil mill effluent (POME) treatment because the demand of oil increases with the awareness on increasing environmental issue. Therefore, a new technology must be found in order to reduce ene-rgy consumption, to meet legal requirements on emission and for cost reduction and also increased quality of water treatment. Membrane Anaerobic System (MAS) is a promising alternative way to overcome these issues. In this study, the efficiency of the MAS performance increases to 99.03% in ten days operation. The application of Monod, Contois and Chen & Hashimoto models were used to analyze the performance of MAS for treating POME. The results from the experiment show the substrate removal model is well fits for estimation of kinetics membrane anaerobic system. Amongst them, the Contois and Monod models predicted the bio-kinetic reactions of the MAS very well with coefficient of determination (R2>97%) values. The MAS bioreactor was created to be an improvement method as well as successful biological treatment since the graph shows linearized which is in good agreement with reported in literature.
Characterization of Agarwood Incense using Gas Chromatography - Mass Spectrometry (GC-MS) coupled with Solid Phase Micro Extraction (SPME) and Gas Chromatography - Flame Ionization Detector (GC-FID)
Authors: Ismail Nurlaila , Lbrahim Mastura , Zareen Seema , Rahiman Mohd Hezri Fazalul , Tajuddin Saiful Nizam , Taib Mohd Nasir
Published: March 2019

This paper presents the application of Solid Phase Micro Extraction (SPME) coupled with Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Flame Ionization Detector (GC-FID) to charaterize agarwood incense. The work involved three types of SPME fibres at 30 minutes sampling time. The fibres are 50/30 µm divinylbenzene-carboxen­polydimethysiloxane (DVB-CAR-PDMS), 65 µm polydi methylsiloxane­divinylbenzene (PDMS-DVB) and 85 µm carboxen-polydimethyl siloxane (CAR-PDMS). The results showed that among many compounds extracted by GC-MS coupled with SPME, six compounds were found significantly presence in high quality aganvood incense due to their high percentage area (%). They are beta-maaliene, alpha-elemol, beta-selinene, 10-epi-gamma-eudesmol, agarospirol and caryophellene oxide. The finding offers a new approach for establishing the volatile profile of agarwood incense components which is beneficial for agarwood grading and discrimination.
Caracterização da emissão foliar de cultivares de alface crespa em função da soma térmica
Authors: Tezza Gisele , Minuzzi Rosandro Boligon
Published: March 2019

O objetivo do estudo foi determinar e comparar variáveis do desenvolvimento vegetal de cultivares de alface crespa (Elba, Camila e Alcione) produzidas em sistema hidropônico do tipo NFT. Determinou-se o filocrono, a área foliar e massa seca. Utilizou-se o delineamento experimental inteiramente casualizado com três tratamentos, cada um com doze repetições. O experimento foi conduzido no Laboratório de Hidroponia, em Florianópolis, no período de 20 de agosto à 04 de outubro de 2018. A semeadura foi realizada, permanecendo primeiramente em estufa de germinação, passando para maternidade, berçário e bancada final. No berçário haviam 10 perfis com espaçamento de 10 cm entre plantas e 5,5 cm entre perfil e na bancada final eram 8 perfis com espaçamento de 25 cm entre plantas e 17 cm entre o eixo central de cada perfil. A colheita foi efetuada 44 dias após a semeadura, sendo que no berçário permaneceram por 15 dias e na bancada final 19 dias. A cultivar Elba apresentou o menor filocrono, indicando que precisou de menos soma térmica para emitir suas folhas, porém sua área foliar não se apresentou como a maior. A cultivar Alcione apresentou menor área foliar e seu filocrono não foi o maior. Para massa seca não houve diferença entre as cultivares.
Evaluation of heavy metal contamination in sediments of the Seybouse River, Guelma – Annaba, Algeria
Authors: Talbi Hanane , Kachi Slimane
Published: March 2019

The surface sediments of Seybouse River and its affluents have been studied and assessed to determine their degree of heavy metal contamination (Cd, Pb, Cu, Ni, Zn and Fe). The contamination factor (CF), the contamination degree (CD) and statistical tools (correlation and APC) has been used in assessing: metal contamination, sediment toxicity and to identify the origin of metals which have enriched the sediments. Heavy metals concentrations of sediments are generally heterogeneous and vary according to the metal and the sampling site. The results have been compared to the reference values of the unpolluted sediments and have shown that Seybouse River sediments are more contaminated by Pb, Cd and Zn respectively. CF values indicate moderate to considerable contamination for most stations. CD values show that the most toxic sediments are located mainly at the estuary and downstream of large agglomerations. The matrix correlation between the metallic elements shows a very strong correlation between Pb, Cd, Cu and Zn indicating that they have a similar source. These different metallic elements appear as traces of anthropogenic pollution. Despite using wastewater treatment plants as protective measures, Seybouse River pollution is remaining a big issue and more efforts has to be done by local authorities.
Age structure, condition and length increase of the topmouth gudgeon (Pseudorasbora parva Schlegel 1842) in non-native populations of small rivers of Poland
Authors: Czerniejewski Przemysław , Zatoń Kinga , Kasowska Natalia , Brysiewicz Adam
Published: March 2019

Monitoring studies of ichthyofauna, in particular non-indigenous species, are an important element of research on aquatic ecosystems. This information is essential for modelling population growth and predicting rates of expansion, quantifying ecological impacts and assessing the efficacy of removal and control strategies. Actually, the most compelling fish invasion in Polish freshwaters is arguably the accidental introduction of the topmouth gudgeon (Pseudorasbora parva). Age and lengths structure, condition factor and growth rate of the invasive populations of the topmouth gudgeon from small Polish rivers was examined. The samples were collected from the rivers: Molnica (n = 41), Myśla (n = 21) and Wardynka (n = 101) soon after the invasion was recorded (2017). Estimated ages of topmouth gudgeon ranged from 1+ to 3+ for the Myśla River, from 1+ do 4+ for the Molnica River, and from 1+ to 5+ for the Wardynka River. The fish from the Molnica River was characterised by the lowest total and standard length (TL, SL), weight, and highest condition. The results of back-calculations and the parameters of von Bertalanffy’s growth equation revealed distinct disproportions in the standard length (mm) in individual age groups (Molnica River: Lt = 54.94 [1 – e−0.68885 (1 − 0.003404)], Myśla River: Lt = 55.39 [1 – e−0.74921 (1 – 0.030962)], Wardynka River: Lt = 66.33 [1 – e−0.69348 (1 – 0.369505)]). The introduction of the topmouth gudgeon occurred in the upper and medium sectors of small rivers, but in subsequent years the species migrated to new sites further downstream and this may have affected the native ichthyofauna.
Possibilities and limitations of using Lemna minor, Hydrocharis morsus-ranae and Ceratophyllum demersum in removing metals with contaminated water
Authors: Gałczyńska Małgorzata , Mańkowska Natalia , Milke Justyna , Buśko Marta
Published: March 2019

The paper presents the assessment of possibilities and limitations of the use of Lemna minor, Hydrocharis morsus-ranae and Ceratophyllum demersum in removing metals from contaminated waters. Synthetically discussed the role of these species in phytotechnology and their importance in the assessment of surface water status. The variability of concentration of selected metals in waters and the content of metals in the organs of the analysed plants are presented. Their advantages and disadvantages in removing metals from waters due to biological features have been characterized. Minimum and maximum efficiency of metal removal depending on the scale of water pollution was determined. It was found that analysed plants can be used for phytoremediation of metals from water, but the limitation of effectiveness of treatments is the toxicity of these metals to plants and the time of exposure. The highest removal efficiency can be obtained thanks to the use of sequences of single-species filtration systems.
İDİYOPATİK PARKİNSON HASTALARINDA OLFAKTÖR BULBUS VOLÜM VE OLFAKTÖR SULKUS DERİNLİĞİNİN MANYETİK REZONANS GÖRÜNTÜLEME İLE DEĞERLENDİRİLMESİ
Authors: DOĞAN Adil , BURULDAY Veysel , ALPUA Murat
Published: March 2019

Amaç: Bu çalışmada idiopatik Parkinson hastalığı
(İPH) olan bireylerde, olfaktör bulbus (OB) hacimleri ve olfaktör sulkus (OS) derinliğini
incelemek amaçlandı.Gereç ve Yöntem: Bu çalışma retrospektif bir olgu kontrol
çalışması olarak dizayn edildi. Manyetik rezonans görüntüleme (MRG) incelemeleri,
standart bir kafa koili kullanılarak, 1.5-tesla MRG sistemi (Philips MRI Systems,
Achieva Release 3.2 Level 2013-10-21, Philips Medical) ile yapıldı. OB hacim hesaplamaları
ve OS derinlik ölçümü için yağ baskılı T2A koronal kesitler kullanıldı ve İPH grubundaki
hastaların verileri sağlıklı kontrol grubu ile karşılaştırıldı.Bulgular: Çalışmaya yaş ortalaması 69.07±10.48 yıl olan 39 İPH hastası ile
yaş ortalaması 69.57±10.12 yıl olan
40 sağlıklı kontrol dahil edildi. İPH hasta grubu ile kontrol grubu karşılaştırıldığında
sağ (30.12±6.49, 39.13±6.55) ve sol
(32.57±8.08, 38.17±4.96) OB hacimleri
ile sağ (6.91±0.9, 7.39±0.65) ve
sol (6.82±0.7, 7.38±0.58) OS derinliklerinin
hasta grupta kontrollere göre belirgin olarak azaldığı görüldü.

Sonuç: İPH hastalarında,
OB hacimleri ve OS derinliklerinin sağlıklı kontroller göre belirgin olarak azaldığı
ve bu durumun hastaların tedavi ve yaşam kalitelerinin yönetimi açısından önem taşıdığı
sonucu ortaya çıkmıştır.
Atención a adolescentes y jóvenes de origen inmigrante en centros de Cáritas Diocesana de Barcelona: factores de riesgo y de protección
Authors: Quiroga Violeta , Chagas-Lemos Eveline
Published: March 2019

Se presenta una investigación realizada en dos centros de Cáritas Diocesana de Barcelona que intervienen con adolescentes y jóvenes de familias inmigradas: el Centro Abierto Glamparetes (adolescentes de 14 a 16 años) y Casal de joves Llops Taga (jóvenes de 16 a 25 años). Los objetivos fueron conocer el grado de integración de los hijos e hijas de familias de origen inmigrante, identificar los principales factores de riesgo y de protección existentes y proponer propuestas de mejoras para llevar una mejor integración de esta población. La metodología que se ha desarrollado es de carácter cualitativa. Para conocer diferentes dimensiones de la vida de los adolescentes y jóvenes participantes en el estudio se han realizado 38 entrevistas en profundidad a los propios adolescentes y jóvenes, a miembros de sus familias (solo en el caso del Centre Obert), a los educadores referentes, a la trabajadora social de Servicios Sociales del territorio y al director o coordinador del centro abierto. Como resultados de la investigación se pone de relieve cómo la intervención en estos recursos es un factor preventivo de las situaciones de riesgo social (en los ámbitos jurídico, familiar, educativo, formativo, económico, salud e identitario), a la vez que aumenta los factores de protección. Igualmente, se destaca el papel del trabajo social en la prevención de situaciones de riesgo con este colectivo.
La familia y la construcción del posicionamiento laboral en las mujeres. Un análisis desde el Trabajo Social
Authors: Carrillo-Montoya Teresita del niño Jesús , Tereso-Ramírez Leonor , González-Ramírez Elizabeth
Published: March 2019

Esta contribución es un análisis inicial de un estudio dirigido a conformar un referente teórico conceptual de la categoría posicionamiento laboral. Se parte de entender que el posicionamiento laboral es un hecho observable como resultado de un proceso reflexivo de los sujetos sociales, desde el constreñimiento de la estructura y la acción, como resultado de su propia agencia de estrategias que les han permitido ser visibles en un espacio como el mercado de trabajo. Se hace el planteamiento de que el proceso de motivación, intención y reflexión que hacen tres mujeres participantes en este estudio, desde sus circunstancias familiares, fueron plataforma para la construcción de su posicionamiento laboral. Cómo método el análisis discursivo constituye un acercamiento que, desde el Trabajo Social y el género, permite el entendimiento de las dinámicas familiares como experiencias que dinamizan acciones en los sujetos sociales y para este caso en las mujeres como agentes que logran transformar roles impuestos e idearios de desigualdad en la búsqueda de su realización y bienestar a partir del posicionamiento laboral.
Transformación constructiva y productiva de conflictos: un enfoque pertinente y necesario en los procesos de construcción de las Paces en Colombia.
Authors: Guillermo Muñoz Federico
Published: March 2019

El proceso de negociación política de la “Mesa de Conversaciones para la terminación del conflicto y la construcción de una paz estable y duradera”, conocido como los “Diálogos de Paz de La Habana” (Cuba) materializó el fin del conflicto armado entre el Estado colombiano y las Farc–EP, donde sobresalen los múltiples y diversos aportes de esta experiencia para seguir avanzando en largos y complejos procesos de construcción de las Paces. También nos permite reflexionar sobre la transformación del conflicto armado, social y político, que no equivale a la súbita desaparición de los conflictos en la sociedad colombiana, ni nos transporta automáticamente a la Paz. Proponemos en este artículo considerar la puesta en práctica del enfoque de la transformación constructiva y productiva de conflictos, que abre el panorama de alternativas, y contribuye a mejorar la comprensión que podemos tener sobre el posconflicto armado, los procesos de construcción de las paces y el horizonte de la reconciliación.
Investigación para la acción, acción para la investigación en población víctima del conflicto armado.
Authors: Carrera-Díaz Patricia Eugenia
Published: March 2019

Este documento producto de investigación sigue el paradigma crítico social con un enfoque cualitativo. El tipo de investigación es Investigación Acción. A partir de un diagnóstico participativo, se proponen cinco sublíneas que configuran la acción: planteamiento, desarrollo y alcance, así como su reflexión, presentándose los principales hallazgos y conclusiones. Se revisan algunos elementos epistemológicos, teóricos, conceptuales y metodológicos de la Investigación Acción, en relación con el voluntariado, la familia, las Ciencias Sociales y la convivencia en la cotidianidad de la organización. Se concluye que la violencia sociopolítica se suma a las violencias cotidianas que deben incluirse en los distintos procesos que se adelanten con la población beneficiaria y se llama la atención sobre las lógicas de campo en la investigación y las que el sistema exige a la Academia.
Educación inclusiva en las Instituciones Educativas de Caicedonia-Valle del Cauca.
Authors: Acosta-Escobar Lina Alejandra , Lugo-Morales Jhina Marcela , Solano-Cárdenas Fanor Julián
Published: March 2019

En el presente artículo de investigación se describen y analizan las condiciones que durante el año 2015 ofrecían las Instituciones Educativas Colegio Bolivariano y Colegio Normal Superior, del municipio de Caicedonia-Valle del Cauca, para garantizar el derecho a la educación inclusiva a las personas con alteraciones a nivel sensorial y del habla. El análisis se fundamenta en información aportada por cinco informantes, observación no participante en las instituciones y análisis documental. Se concluye que las instituciones educativas del municipio de Caicedonia permiten el acceso de las personas con alteraciones a nivel sensorial y del habla a las aulas, pero no ofrecen una educación inclusiva integral en la medida que presentan fallas en el cumplimiento de parámetros como la asequibilidad, la aceptabilidad y la adaptabilidad curricular. Este hecho obstaculiza el desarrollo pleno de las potencialidades de la población en condición de diversidad funcional y contribuye a reafirmar los procesos históricos de exclusión social de los que ha sido objeto.
Retos y desafíos de las políticas públicas para la igualdad de género y los derechos humanos, en el marco de la agenda 2030 y los objetivos de desarrollo sostenible
Authors: Londoño-López Martha Cecilia
Published: March 2019

Desde el punto de vista teórico, la investigación Representaciones Colectivas sobre Pobreza en las Comunas 1 y 3 de la Ciudad de Medellín, se fundamentó en dos pilares para comprender y analizar las lógicas de empobrecimiento que tienen lugar en las sociedades contemporáneas que se rigen bajo el modelo de desarrollo capitalista.

El primer pilar lo constituye un acercamiento a las diferentes concepciones y corrientes teóricas orientadas a la definición de la pobreza, que permiten asumir una postura de corte epistemológico amparada en el reconocimiento de que la perspectiva histórico-crítica ofrece una amplia posibilidad para el entendimiento de la pobreza, como fenómeno de orden estructural.

El segundo pilar es el establecimiento de algunos referentes para la construcción del concepto de representaciones colectivas con aportes de autores como C. Marx, F. Engels, A. Heller, H. Zemenmal, A. Torres, E. Zuleta, P. Netto, M. Iamamoto, F. Borda, Y. Guerra, C. Montaño, A. Simoes da Mota, entre otros, quienes permiten la comprensión de las lógicas de segregación desde la vivencia cotidiana de los mismos pobladores, sin perder de vista la lectura macro estructural de la sociedad para una lectura concreta y situada de las contradicciones que genera la implementación del sistema capitalista en contextos de pobreza.

Se presentan los referentes centrales que orientan el desarrollo de estos dos pilares de trabajo que han permitido establecer una ruta para la comprensión de la pobreza y de la segregación socio espacial. A su vez, permiten el establecimiento y la clarificación de las intencionalidades ético políticas en la interacción con el territorio, con los sujetos y con los grupos poblacionales que enfrentan las lógicas de empobrecimiento y vulneración social, espacial, económica y política y se movilizan por el derecho al territorio y a la ciudad.
Apologetic approach on the dialogue between faith and rationality by the Oriental Fathers
Authors: Apostolache Ioniţă
Published: March 2019

Only our Lord, Jesus Christ, the incarnated Word of the Father, made us, due to his quality as Pantocrator, to “overcome the autonomy of the natural world” and liberated us from the power of irrational forces. Therefore, the dialogue between theology and science is very important for our natural existence. Without science, modern man cannot exist within his earthly environment and without theology he is not given the possibility to enjoy eternal communion with God in the Kingdom of Heaven. This being the case, the Holy Scripture and the Holy Father also, unite the two elements; this unity being sheltered by faith, which is beyond reason and any type of autonomy.
Św. Demetriusz jako pogromca zła w tradycji bizantyńskiej i słowiańskiej (do XV w.)
Authors: Sprutta Justyna
Published: March 2019

W każdej tradycji zło jest zwyciężane przed dobro, ciemność przez światłość, profanum przez sacrum. Analogiczne zwycięstwo odnoszą święci, a wśród nich św. Demetriusz z Tesaloniki. Mimo iż był diakonem, w sztuce najczęściej przedstawiany jest jako żołnierz. Legenda mówi, że w więzieniu pokonał znakiem krzyża skorpiona personifikującego zło. Zamiast skorpiona może także zwyciężać gladiatora Lieusa, cesarza Maksymiana, cara Kałojana lub Turka, a czyni to konno lub pieszo, za pomocą oręża lub poprzez gest calcatio. Nie tylko mówią o św. Demetriuszu źródła historyczne, teksty liturgiczne czy literatura piękna, ale także sztuka i folklor.
Biblijne i dogmatyczne podstawy nauki o szatanie oraz współczesne kryteria jej oceny
Authors: Jaskóła Piotr
Published: March 2019

Starożytny Wschód przypisywał personalny charakter tysiącom tajemniczych sił, których obecność wiązano z wszelkim złem, jakie nawiedza człowieka. Także w Biblii mówi się nie tylko o dobrych istotach duchowych – aniołach, ale i o takich, które szkodzą ludziom, przynoszą choroby i kuszą do złego. Duchy te nazywano demonami, a ich przywódcę szatanem lub diabłem. Artykuł w czterech punktach ukazuje biblijną naukę o demonach i szatanie, główne trendy rozwoju tej nauki w historii myśli chrześcijańskiej oraz kryteria stosowane we współczesnej hermeneutyce związanej z biblijnymi tekstami o demonach i szatanie
Theology and the public arena from a Polish point of view
Authors: Glombik Konrad Józef
Published: March 2019

Jednym z ważnych aktualnych problemów teologicznych jest miejsce teologii w przestrzeni publicznej. Wiążą się z tym pytania o doświadczenia i problemy, ale także możliwości i wyzwania, które mają dość mocne zabarwienie kontekstualne. Niniejszy artykuł przedstawia tę problematykę z perspektywy doświadczeń i możliwości w Polsce. Na początku, w oparciu o refleksje polskich teologów, został przedstawiony związek przestrzeni publicznej z naturą teologiii zadaniami, jakie ma pełnić w Kościele i społeczeństwie. Szczególnym rysem charakterystycznym jest w tym względzie wymiar eklezjalny teologii. W dalszej kolejności zostały ukazane rodzaje przestrzeni publicznej, w których możliwa jest obecność teologii i jej przedstawicieli. W Polsce jest to sfera polityczna i społeczna, kultura i media, a zwłaszcza środowiska akademickie. W kolejnym punkcie zostały zarysowane doświadczenia i problemy polskiej teologii i polskich teologów z przestrzenią publiczną. Na końcu zostały ukazane główne wyzwania istotne dla obecności teologii w przestrzeni publicznej. Artykuł nie jest całościowym przedstawieniem problematyki, ale jej zarysem i inspiruje do dalszych badań i studiów w tym zakresie.
KEY PROBLEMS OF INTERACTION BETWEEN ORGANIZATIONS IN IMPLEMENTATION JOINT PROJECTS ON RESEARCH AND DEVELOPMENT
Authors: Kafiyatullina Yu. , Panfilova E.
Published: March 2019

Innovative activity of domestic organizations continues to remain low: from 2014 to 2016, there was a reduction in the cost of technological innovations, organizations prefer to import foreign equipment in order to increase the innovation component of the products sold. The way out of the situation is to conduct joint research and development projects, according to the results of which Russian organizations will have the rights to advanced development, acquire competitive competences, which will later allow our country to reduce the technological gap. The article analyzes the current state of research and development, innovation activity, the level of development of digital technologies in our country, which allows to outline the range of problems that hinder the effective implementation of joint research and development projects.
IMPROVING OF STATE STIMULATION MEASURES OF INVESTMENT ACTIVITY IN AGRICULTURE
Authors: Britik E. , Vladimirov V. , Shuldyakov A.
Published: March 2019

The issues for improving the efficiency of state agriculture management on the basis of investment activity stimulation taking into account modern measures of financial support for agricultural enterprises have been considered. The main reasons and factors that determine the need to strengthen measures of state financial support for investment activities in the agrarian and industrial complex have been presented. The analysis of the amount, dynamics and structure of sources of capital investments financing has been carried out, the place and the importance of some definite state financial support forms in investment processes have been shown. The existing problems for increasing the efficiency of state investment policy in agriculture in modern conditions have been revealed. The conclusion on inadmissibility of reducing the state support level for the branch, the necessity for its further improvement in order to maintain and increase the achieved rates of agricultural production development in Russia has been made.
ESSENCE OF THE PROBLEMS OF PERFORMANCE MANAGEMENT OF PROFESSIONAL SERVICE ACTIVITIES OF CIVIL SERVANTS AT THE STAGE OF RECRUITMENT AND SELECTION
Authors: Simutova D.
Published: March 2019

The problems of managing the effectiveness of professional service activities of civil servants, expressed in the lack of professionalism and competence of employees, have been investigated. The problems that arise at the stage of attracting personnel to the civil service of the Russian Federation have been considered from the point of view of the established qualification requirements for civil service positions. The cause of the problems at the selection stage has been disclosed in the practice of using methods for evaluating candidates for positions in the civil service.
MECHANISM OF INNOVATIVE INFRASTRUCTURE OF SUPPORT OF SMALL BUSINESS DEVELOPMENT
Authors: Rudenko L.
Published: March 2019

The relevance of the stated theme is determined by the target setting of the Russian state to build a new economy of an innovative type, where small enterprises can become drivers of innovative development. The article investigates the issues of innovation development in Russia and in particular small innovative entrepreneurship. Based on the analysis of the current situation, the problems that hinder the innovative activity of small businesses have been identified, the main of which is the unformed mechanism of innovation infrastructure to support small business. The author’s interpretation of the mechanism of innovative infrastructure of support of small business has been offered. The сreated mechanism of innovation infrastructure to support small businesses can serve as the basis of scientific and instrumental approach to the formation of strategies and programs for the development of small innovative enterprises.
THE PREDICTION OF ENTERPRISES ACTIVITY INDICATORS TAKING INTO ACCOUNT THE INITIAL DATA UNCERTAINTY
Authors: Gagarin Yu. , Gagarina S.
Published: March 2019

The mathematical method of making forecasts when the initial data uncertainty have been considered. To obtain point and interval estimates of the parameters of mathematical models that take into account errors in the values of the function and argument, the use methods of confluent analysis has been proposed. For linear models, point estimates and confidence intervals of predictions have been found. The developed method is used to solve the problem of forecasting the volume of services provided by organizations of the housing and utilities complex. The sales volume simulating for different values of time intervals has been conducted and the influence of the initial information error on the model parameter values and predicted values has been analyzed.
“Sleeping Beauty” Phenomenon: SuFEx-Enabled Discovery of Selective Covalent Inhibitors of Human Neutrophil Elastase
Authors: Zheng Qinheng , Woehl Jordan L. , Kitamura Seiya , Santos-Martins Diogo , Smedley Christopher J. , Li Gencheng , Forli Stefano , Moses John E. , Wolan Dennis W. , Sharpless K. Barry
Published: March 2019

Sulfur-Fluoride Exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled approach exploiting the “sleeping beauty” phenomenon of sulfur fluoride compounds in the context of the serendipitous discovery of selective covalent human neutrophil elastase (hNE) inhibitors. Evaluation of an ever-growing collection of SuFExable compounds toward various biological assays unexpectedly yielded a selective and covalent hNE inhibitor, benzene-1,2-disulfonyl fluoride. Derivatization of the initial hit led to a better agent, 2- triflyl benzenesulfonyl fluoride, itself made through a SuFEx trifluoromethylation process, with IC50 = 1.1 μM and ~200-fold selectivity over the homologous neutrophil serine protease, cathepsin G. The optimized probe only modified active hNE and not its denatured form, setting another example of the “sleeping beauty” phenomenon of sulfur fluoride capturing agents for the discovery of covalent medicines.
Anomalous Cracking in a Metal-Organic Framework Glass
Authors: Stepniewska Malwina , Januchta Kacper , Zhou Chao , Qiao Ang , Smedskjaer Morten M. , Yue Yuanzheng
Published: March 2019

Metal-organic framework (MOF) glasses is a newly discovered family of melt-quenched glasses. Recently, several intriguing features (e.g., ultrahigh glass forming ability and low liquid fragility) have been discovered in the glasses obtained from zeolitic imidazolate frameworks (ZIFs) that are a subset of MOFs. However, the fracture behavior of ZIF glasses remains elusive. Here, we report on the first important finding, namely, the anomalous crack behavior in a representative ZIF glass, i.e., ZIF-62 glass with the chemical composition of ZnIm2-xbImx, where the central node – zinc - is coordinated to imidazolate (Im) and benzimidazole (bIm) ligands. By performing micro- and nano-indentation and atomic force microscopy (AFM) analysis, we observe a unique sub-surface cracking phenomenon with induced shear bands on the indent faces, in contrast to the cracking behavior of other types of network glasses. The occurrence of shear bands could be attributed to the breakage of coordinative bonds that are much weaker than ionic and covalent The observed anomalous cracking behavior accords with the high Poisson’s ratio (=0.34) of the ZIF-62 glass.
Synthesis and Reactivity of Precolibactin 886
Authors: Herzon Seth , Healy Alan R. , wernke kevin , Kim Chung Sub , Lees Nicholas , Crawford Jason M.
Published: March 2019

The clb gene cluster encodes the biosynthesis of metabolites known as precolibactins and colibactins. The clb pathway is found in gut commensal E. coli, and clb metabolites are thought to initiate colorectal cancer via DNA cross-linking. Precolibactin 886 (1) is one of the most complex isolated clb metabolites; it contains a 15-atom macrocycle and an unusual 5-hydroxy-3-oxazoline ring. Here we report confirmation of the structural assignment via a biomimetic synthesis of precolibactin 886 (1) proceeding through the amino alcohol 9. Double oxidation of 9 afforded the unstable α-ketoimine 2 which underwent macrocyclization to precolibactin 886 (1) upon HPLC purification (3% from 9). Studies of the putative precolibactin 886 (1) biosynthetic precursor 2, the model α-ketoimine 25, and the α-dicarbonyl 26 revealed that these compounds are susceptible to nucleophilic rupture of the C36–C37 bond. Moreover, cleavage of 2 produces other known clb metabolites or biosynthetic intermediates. This unexpected reactivity explains the difficulties in isolating full clb metabolites and accounts for the structure of a recently identified colibactin–adenine adduct. The colibactin peptidase ClbP deacylates synthetic precolibactin 886 (1) to form a non-genotoxic pyridone, suggesting precolibactin 886 (1) lies off-path of the major biosynthetic route.
Differential radiological diagnosis of tuberculous sacroiliitis and bone involvement in Gaucher disease: a clinical case
Authors: Soloveva A A , Ponomarev R V , Lukina K A , Mamonov V E , Khomenko V A , Kostina I E , Yatsyk G A , Lukina E A
Published: March 2019

Differential diagnosis of bone involvement in patients with Gaucher disease can be challenging. Other diseases with similar radiological signs should be ruled out. Here we present a clinical case of tuberculous sacroiliitis in the patient with type I Gaucher disease. Advanced radiological methods of examination are described. Our case report proves the necessity of an individual approach to the management of such cohort of patients.
Protective measures of patients with cardiovascular diseases from exposure to heat waves: medicated and non-medicated
Authors: Smirnova M D , Svirida O N , Ageev F T
Published: March 2019

In conditions of climate warming with an increase in heat waves associated with an increase in cardiovascular morbidity and mortality, the particular interest is the effect of cardiovascular drugs on adaptation to high temperatures. The review reflects the results of European and domestic studies on the safety of therapy during long and short heat waves. Recommendations for the correction of therapy during this period are given. Self-control of blood pressure (SCAD) is a mandatory component of the therapy of arterial hypertension during heat waves. With the development of clinically significant hypotension, a reduction in the dose of antihypertensive drugs is necessary. It is recommended to start with a dose reduction and/or withdrawal of diuretics and nitrates. Not recommended the complete abolition of antihypertensive therapy because of the risk of hypertensive crises, characteristic of abnormal heat, as well as due to the increase in blood pressure when the weather changes and the temperature drops. With increasing blood pressure during heat waves, it is recommended to give preference to calcium channel antagonists, angiotensin converting enzyme inhibitors (ACE inhibitors) and selective beta-blockers. It is necessary to inform patients about the additional protective effect of statins in order to increase adherence to therapy. Patients taking diuretics require individual daily monitoring of fluid intake and body weight. An overview of recommendations on sanogenic behavior during heat waves is given. Details are considered rules for the use of air conditioning, methods of diagnosis of dehydration and drinking mode
ẢNH HƯỞNG CỦA TẠP Ca ĐẾN TÍNH CHẤT NHIỆT ĐIỆN CỦA HỆ GỐM CuAlO2
Authors: Tùng Võ Thanh , Tú Lê Trần Uyên , Trang Dụng Thị Hoài , Tĩnh Nguyễn Trọng
Published: March 2019

Hệ gốm CuAl1-xCaxO2 (0  x  0.2) được chế tạo bằng phương pháp phản ứng pha rắn. Ảnh nhiễu xạ tia X của các mẫu vật liệu cho thấy bên cạnh pha CuAl1-xCaxO2 với cấu trúc mặt thoi đặc trưng còn tồn tại các đỉnh của các pha CuO, CaO và CaAl4O7. Từ ảnh SEM có thể nhận thấy rằng tạp Ca làm tăng kích thước hạt của vật liệu nền. Mặc dù làm giảm độ dẫn điện nhưng tạp Canxi làm tăng đáng kể hệ số Seebeck của vật liệu, nên hệ số công suất (PF) của hệ được cải thiện. Ở nhiệt độ thiêu kết 1423 K, hệ gốm CuAl0.95Ca0.05O2 ứng với x=0.05 đạt hệ số công suất cao nhất là 5.09×10−5Wm−1K−2. Kết quả nghiên cứu cho thấy tạp Ca đóng vai trò quan trọng trong việc cải tiến các tính chất nhiệt điện của hệ CuAlO2 ở vùng nhiệt độ cao.
Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations
Authors: Volpe Giacomo , Cauchy Pierre , Walton David S , Ward Carl , Blakemore Daniel , Bayley Rachael , Clarke Mary L , Schmidt Luisa , Nerlov Claus , Garcia Paloma , Dumon Stéphanie , Grebien Florian , Frampton Jon
Published: March 2019

Mutations at the N- or C-terminus of C/EBPα are frequent in acute myeloid leukaemia (AML) with normal karyotype. Here, we investigate the role of the transcription factor Myb in AMLs driven by different combinations of CEBPA mutations. Using knockdown of Myb in murine cell lines modelling the spectrum of CEBPA mutations, we show that the effect of reduced Myb depends on the mutational status of the two Cebpa alleles. Importantly, Myb knockdown fails to override the block in myeloid differentiation in cells with biallelic N-terminal C/EBPα mutations, demonstrating for the first time that the dependency on Myb is much lower in AML with this mutational profile. By comparing gene expression following Myb knockdown and chromatin immunoprecipitation sequencing data for the binding of C/EBPα isoforms, we provide evidence for a functional cooperation between C/EBPα and Myb in the maintenance of AML. This co-dependency breaks down when both alleles of CEBPA harbour N-terminal mutations, as a subset of C/EBPα-regulated genes only bind the short p30 C/EBPα isoform and, unlike other C/EBPα-regulated genes, do so without a requirement for Myb.
Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection
Authors: Albers Julian J , Ammon Tim , Gosmann Dario , Audehm Stefan , Thoene Silvia , Winter Christof , Secci Ramona , Wolf Anja , Stelzl Anja , Steiger Katja , Ruland Jürgen , Bassermann Florian , Kupatt Christian , Anton Martina , Krackhardt Angela M
Published: March 2019

Adoptive transfer of TCR transgenic T cells holds great promise for treating various cancers. So far, mainly semi-randomly integrating vectors have been used to genetically modify T cells. These carry the risk of insertional mutagenesis, and the sole addition of an exogenous TCR potentially results in the mispairing of TCR chains with endogenous ones. Established approaches using nonviral vectors, such as transposons, already reduce the risk of insertional mutagenesis but have not accomplished site-specific integration. Here, we used CRISPR-Cas9 RNPs and adeno-associated virus 6 for gene targeting to deliver an engineered TCR gene specifically to the TCR alpha constant locus, thus placing it under endogenous transcriptional control. Our data demonstrate that this approach replaces the endogenous TCR, functionally redirects the edited T cells’ specificity in vitro, and facilitates potent tumor rejection in an in vivo xenograft model.
A existência no texto poético performatizado de Oswaldo Montenegro
Authors: Filgueira André Luiz De Souza
Published: March 2019

Este artigo explora os conceitos de performance, de Paul Zumthor, e existência, de Albert Camus. Na sequência, são rastreados, no texto poético das canções de Oswaldo Montenegro, especificamente no álbum De passagem, do ano de 2011, os sentidos existenciais performatizados abertos nas letras do artista em tela.
O século XX e a tragédia do homem comum
Authors: Rabelo Adriano De Paula
Published: March 2019

No decorrer do século XX, houve um grande debate em torno da tragédia e da possibilidade de sua recriação num tempo tão distante do século V a.C., quando ocorreu seu surgimento e seu apogeu e quando Ésquilo, Sófocles e Eurípides, os três grandes tragediógrafos da Grécia, produziram seus trabalhos. Pensadores originários de diversos campos das humanidades tomaram parte nessas discussões. Este artigo sintetiza suas ideias, mostrando como a estatura do ser humano, sua condição social e sua linguagem foram se rebaixando até o século em que autores como Eugene O’Neill, Arthur Miller e Nelson Rodrigues recriaram a tragédia em feição moderna: uma tragédia do homem comum.
Lukács y las robinsonadas del siglo XVIII:
Authors: Koval Martín Ignacio , Lenga Jesica
Published: March 2019

En este artículo se aborda un corpus de robinsonadas del siglo XVIII a la luz de la noción de laboriosidad, que Lukács desarrolla en “La novela” (1934). La categoría de trabajo está en el centro de estas novelas y la laboriosidad es el atributo básico de sus héroes, los Robinsones. El que todos los Robinsones sean protestantes y que su trabajo pueda ser calificado, con Marx, como no alienado, son las dos manifestaciones de aquel concepto clave que serán estudiadas.
Crítica literaria y marxismo en América Latina – paradojas
Authors: Rojas Juan Pedro
Published: March 2019

Este trabajo pretende discutir la paradoja de tener en América Latina una producción literaria de alta calidad en condiciones económicas y sociales atrasadas y periféricas.  El debate comienza con los escritos de Marx y Engels sobre estética literaria donde abordan la relación entre estructura y superestructura, la independencia de fines del arte y las incongruencias entre el desarrollo de la capacidad artística y el   de las fuerzas productivas. Posteriormente analiza algunos casos específicos que tienen que ver con esta problemática en América Latina: 1- La plasticidad cultural que encontramos en los escritores de nuestra región a partir del análisis crítico de Ángel Rama y Antonio Candido, la figura de Machado de Assis en Brasil estudiada por Roberto Schwarz, y la figura de Borges en Argentina a través del estudio crítico de Beatriz Sarlo.
O cortejo da morte engendra a narrativa:
Authors: Reis Luiz Carlos Menezes
Published: March 2019

Este artigo analisa o conto de Samuel Rawet intitulado Um homem morto, um cavalo morto, um rato morto que aparece em seu último livro intitulado: Que os mortos enterrem seus mortos de 1981. Ao aproximar o conto dos conceitos de Gilles Deleuze e Félix Guattari estabelece-se um diálogo entre literatura e filosofia que permeia as leitura da obra. Podemos então observar que o personagem se duplica em um devir-animal e em obsessões que caracterizam a obra de Rawet.
Samuel Rawet e Clarice Lispector no entre-lugar
Authors: Chiarelli Stefania , Pena Thays Freitas de Almeida
Published: March 2019

Adotando como ponto de partida a concepção de Mikhail Bakhtin de que todo ato cultural vive nas fronteiras, este estudo busca explanar como a ideia das fronteiras culturais e seus limites elásticos é articulada nos estudos culturais e na Literatura Comparada, perspectiva essa escolhida como baliza desta pesquisa. A interação que proponho entre as obras Contos do imigrante (1956) e Laços de família (1960) partilha da proposta de amalgamar fronteiras realizada pela literatura comparada em consonância com os estudos culturais. Os autores viveram no entre, nesse espaço intermediário e paradoxal, sendo assim, a indefinição de estar no mundo é o que há de mais íntimo em Rawet e Clarice, que se instalam no caminho do meio que a literatura propõe.
AS Pálidas flores de Rosalina
Authors: Perna Filho Francisco
Published: March 2019

O presente artigo é um estudo sobre a construção da personagem feminina Rosalina, do romance Ópera dos mortos (1967), de Autran Dourado. Sua base teórica é constituída pelas teorias de Ecléa Bosi (2003), em seu estudo sobre tempo e memória; Georges Bataille (2013), que se detém no Erotismo; Lúcia Castello Branco (1991), que, ao analisar a escrita feminina, dedica um capítulo ao estudo da memória; Sigmund Freud (2014), que dedica um estudo ao luto e à melancolia; e, por último, Autran Dourado (1982; 2000), em seus estudos sobre sua própria obra. A categoria principal desta análise é a memória coletiva e individual. A partir dela, outras categorias são destacadas: a intertextualidade, a metatextualidade e o erotismo. Tentou-se aqui mostrar como e porquê Ópera dos mortos é um trabalho de grande labor estético e apurado senso crítico.