bluuebunny/crossref_metadata_2025 huggingface dataset:
Three point shooting and efficient mixed strategies: A portfolio management approach
Authors: Fichman Mark , O’Brien John
Published: October 2017

Using mean/variance investment theory, we identify the efficient mixed shot type strategy for National Basketball Association (NBA) teams. The proportion of 3-point shots in this mixed strategy closely tracks risk and the change in expected points from 1979–2014. We then extend this approach to an individual team level for both offense and defense. This measures both the risk associated with implementing a mixed strategy (for and against an individual team) and the implied shot type efficiency for offense and defense. It is the latter, shot type efficiency, which predicts winning and winning point differential.
When to call on an advantageous restart option
Authors: McGarvey Ronald G.
Published: October 2017

In an NCAA wrestling match, a coin toss occurs at the end of the first period. The coin toss winner can elect to begin the second period in a position he views as advantageous, in which case his opponent will determine the third period’s starting position, or the coin toss winner can defer his choice of starting position until the third period. This study examines two questions: What is the impact of the coin toss on the ultimate match outcome? Having won the coin toss, is it preferable to select the restart position in the second or the third period? The analysis finds that winning the coin toss does not, in itself, have a significant effect on the ultimate match outcome. However, the decision to defer has a considerable negative effect on the ultimate match outcome for the coin toss winner, with this effect being strongest when the match score is close at the end of the first period. This result is particularly surprising, given that wrestlers do not appear to demonstrate a uniform preference for deferring in close matches.
A weighted plus/minus metric for individual soccer player performance
Authors: Schultze Steven R. , Wellbrock Christian-Mathias
Published: October 2017

Despite soccer being the number one sport in the world in many respects, the “beautiful game” still lags behind other sports in terms of analytics. We propose a weighted plus/minus metric to be used as an instrument to evaluate player performance. An unweighted plus/minus metric subtracts goals conceded from goals scored for each player while on the field of play and are regularly used in hockey or basketball. Key improvements to this established, unweighted +/– metric include control for opponents’ strength, the importance of a particular goal, and considerations for the fact that scoring is less frequent in soccer. The results from three teams (Bayern Munich, VfL Wolfsburg, Werder Bremen) in the German Bundesliga from the 2012-13 season were used as a demonstration and comparison of the two metrics. In addition to the creation of a weighted +/– system, a spatial mapping system of team shots was developed to give a potential visual explanation of why certain players were a net positive/negative influence for their team.
Walter Scott and Blackwood's: Writing for the Adventurers
Authors: Lumsden Alison
Published: October 2017

The significance of Scott as a literary and cultural critic is little understood. Yet Scott was a lively participant in journal culture and contributed to it throughout his publishing career, writing for Blackwood's from its inception in 1817 until near the end of his life in 1829. Scott established himself as one of the finest critics and reviewers of his day, offering pertinent remarks on, among others, Byron, Mary Shelley, and Austen. This article explores Scott's contributions to Blackwood’s, his reasons for publishing in this often combative space, and the ways in which it offers Scott an opportunity to explore new aspects of his creativity. It pays attention to Scott's pieces on Scottish gypsies and to his iconic review of Frankenstein. It also examines his forays into the genre of ‘tale’, the ways in which they facilitate the development of the short story, and how they contribute to the development of Scott's career.
An Integrated Risk Index Model Based on Hierarchical Fuzzy Logic for Underground Risk Assessment
Authors: Fayaz Muhammad , Ullah Israr , Park Dong-Hwan , Kim Kwangsoo , Kim DoHyeun
Published: October 2017

Available space in congested cities is getting scarce due to growing urbanization in the recent past. The utilization of underground space is considered as a solution to the limited space in smart cities. The numbers of underground facilities are growing day by day in the developing world. Typical underground facilities include the transit subway, parking lots, electric lines, water supply and sewer lines. The likelihood of the occurrence of accidents due to underground facilities is a random phenomenon. To avoid any accidental loss, a risk assessment method is required to conduct the continuous risk assessment and report any abnormality before it happens. In this paper, we have proposed a hierarchical fuzzy inference based model for under-ground risk assessment. The proposed hierarchical fuzzy inference architecture reduces the total number of rules from the rule base. Rule reduction is important because the curse of dimensionality damages the transparency and interpretation as it is very tough to understand and justify hundreds or thousands of fuzzy rules. The computation time also increases as rules increase. The proposed model takes 175 rules having eight input parameters to compute the risk index, and the conventional fuzzy logic requires 390,625 rules, having the same number of input parameters to compute risk index. Hence, the proposed model significantly reduces the curse of dimensionality. Rule design for fuzzy logic is also a tedious task. In this paper, we have also introduced new rule schemes, namely maximum rule-based and average rule-based; both schemes can be used interchangeably according to the logic needed for rule design. The experimental results show that the proposed method is a virtuous choice for risk index calculation where the numbers of variables are greater.
A Kriging Model Based Finite Element Model Updating Method for Damage Detection
Authors: Yang Xiuming , Guo Xinglin , Ouyang Huajiang , Li Dongsheng
Published: October 2017

Model updating is an effective means of damage identification and surrogate modeling has attracted considerable attention for saving computational cost in finite element (FE) model updating, especially for large-scale structures. In this context, a surrogate model of frequency is normally constructed for damage identification, while the frequency response function (FRF) is rarely used as it usually changes dramatically with updating parameters. This paper presents a new surrogate model based model updating method taking advantage of the measured FRFs. The Frequency Domain Assurance Criterion (FDAC) is used to build the objective function, whose nonlinear response surface is constructed by the Kriging model. Then, the efficient global optimization (EGO) algorithm is introduced to get the model updating results. The proposed method has good accuracy and robustness, which have been verified by a numerical simulation of a cantilever and experimental test data of a laboratory three-story structure.
A Critical Appraisal of Extracorporeal Photopheresis as a Treatment Modality for Acute and Chronic Graft-Versus-Host Disease
Authors: Rafei Hind , Kharfan-Dabaja Mohamed A. , Nishihori Taiga
Published: October 2017

Although significant advances have been made in the biologic understanding of graft-versus-host disease (GVHD) and its treatment options, GVHD remains the single most challenging obstacle to the success of allogeneic hematopoietic cell transplantation (HCT) due to high risk of disabling morbidity and mortality. Extracorporeal photopheresis (ECP) has promising effects in controlling steroid-refractory GVHD, both acute and chronic, and it has been studied extensively. Its putative immunomodulatory mechanisms, while not immunosuppressive, position ECP as an attractive treatment strategy for GVHD patients who are already receiving global immunosuppression. However, ECP is relatively underutilized due in part to limited access and time commitment. Here, we review the recent findings on the ECP efficacy in both acute and chronic GVHD, primarily for steroid-refractory status, and we critically appraise its benefits. We also explore salient considerations on the optimal use of ECP in the treatment of refractory GVHD.
Mitigation of Cr(VI) Aqueous Pollution by the Reuse of Iron-Contaminated Water Treatment Residues
Authors: Gheju Marius , Balcu Ionel
Published: October 2017

Reducing the levels of heavy metals in wastewaters below the permissible limits is imperative before they are discharged into the environment. At the same time, water treatment technologies should be not only efficient, but also affordable. In accordance with these principles, this study assessed the possibility of recovering iron-contaminated residues, resulting from the treatment of synthetic acid mine drainage, for the subsequent remediation of Cr(VI) polluted aqueous solutions. Bentonite, an inexpensive and available natural material, was used as an adsorbent for the removal of Fe(II) from synthetic acid mine drainage (AMD). Then, Fe(II)-contaminated bentonite, the residue generated during the treatment of AMD, was recovered and activated with sodium borohydride in order to convert the adsorbed Fe(II) to Fe(0). Subsequently, the Fe(0)-containing bentonite (Be-Fe(0)) was further used for the treatment of Cr(VI) contaminated aqueous solutions. Reactive materials investigated in this work were characterized by means of scanning electron microscopy-energy dispersive angle X-ray spectrometry (SEM-EDX), X-ray diffraction spectroscopy (XRD), point of zero charge, and image photographs. The effect of several important parameters (pH, temperature, metal concentration, and ionic strength) on both treatment processes was investigated and discussed. It was shown that the efficiency of Cr(VI) removal with Be-Fe(0) was much higher than with bentonite. On the basis of the present study it can be concluded that residues generated during the treatment of AMD with bentonite can be used as a cheap precursor for the production an Fe(0)-based reagent, with good Cr(VI) removal potential.
The Impact of Climate Change on Biodiversity in Nepal: Current Knowledge, Lacunae, and Opportunities
Authors: Bhattacharjee Aishwarya , Anadón José , Lohman David , Doleck Tenzing , Lakhankar Tarendra , Shrestha Bharat , Thapa Praseed , Devkota Durga , Tiwari Sundar , Jha Ajay , Siwakoti Mohan , Devkota Naba , Jha Pramod , Krakauer Nir
Published: October 2017

Nepal has an extreme altitudinal range from 60–8850 m with heterogeneous topography and distinct climatic zones. The country is considered a biodiversity hotspot, with nearly a quarter of the land area located in protected areas. Nepal and the surrounding Himalayan region are particularly vulnerable to climate change because of their abrupt ecological and climatic transitions. Tens of millions of people rely on the region’s ecosystem services, and observed and modeled warming trends predict increased climate extremes in the Himalayas. To study the ecological impacts of climate change in Nepal and inform adaptation planning, we review the literature on past, present, and predicted future climatic changes and their impacts on ecological diversity in Nepal. We found few studies focusing on organisms, while research on species and communities was more common. Most studies document or predict species range shifts and changes in community composition. Results of these few investigations highlight major lacunae in research regarding the effects of changing climate on species comprising the Himalayan biota. Further empirical work is needed at all levels of biological organization to build on information regarding direct ecological impacts of climatic changes in the region. Countries face an ever-increasing threat of climate change, and Nepal has strong physiographic, elevational, and climatic gradients that could provide a useful model for studying the effects of climate change on a mountainous, and highly biodiverse, area.
Enhanced Efficiency of Dye-Sensitized Solar Counter Electrodes Consisting of Two-Dimensional Nanostructural Molybdenum Disulfide Nanosheets Supported Pt Nanoparticles
Authors: Cheng Chao-Kuang , Lin Jeng-Yu , Huang Kai-Chen , Yeh Tsung-Kuang , Hsieh Chien-Kuo
Published: October 2017

This paper reports architecturally designed nanocomposites synthesized by hybridizing the two-dimensional (2D) nanostructure of molybdenum disulfide (MoS2) nanosheet (NS)-supported Pt nanoparticles (PtNPs) as counter electrodes (CEs) for dye-sensitized solar cells (DSSCs). MoS2 NSs were prepared using the hydrothermal method; PtNPs were subsequently reduced on the MoS2 NSs via the water–ethylene method to form PtNPs/MoS2 NSs hybrids. The nanostructures and chemical states of the PtNPs/MoS2 NSs hybrids were characterized by high-resolution transmission electron microscopy and X-ray photoelectron spectroscopy. Detailed electrochemical characterizations by electrochemical impedance spectroscopy, cyclic voltammetry, and Tafel-polarization measurement demonstrated that the PtNPs/MoS2 NSs exhibited excellent electrocatalytic activities, afforded a higher charge transfer rate, a decreased charge transfer resistance, and an improved exchange current density. The PtNPs/MoS2 NSs hybrids not only provided the exposed layers of 2D MoS2 NSs with a great deal of catalytically active sites, but also offered PtNPs anchored on the MoS2 NSs enhanced I3− reduction. Accordingly, the DSSCs that incorporated PtNPs/MoS2 NSs CE exhibited an outstanding photovoltaic conversion efficiency (PCE) of 7.52%, which was 8.7% higher than that of a device with conventional thermally-deposited platinum CE (PCE = 6.92%).
A Comparative Study on Damage Mechanism of Sandwich Structures with Different Core Materials under Lightning Strikes
Authors: Yan Jiangyan , Wang Guozheng , Li Qingmin , Zhang Li , Yan Joseph , Chen Chun , Fang Zhiyang
Published: October 2017

Wind turbine blades are easily struck by lightning, a phenomenon that has attracted more and more attention in recent years. On this subject a large current experiment was conducted on three typical blade sandwich structures to simulate the natural lightning-induced arc effects. The resulting damage to different composite materials has been compared: polyvinyl chloride (PVC) and polyethylene terephthalate (PET) suffered pyrolysis and cracks inside, while the damage to balsa wood was fibers breaking off and large delamination between it and the resin layer, and only a little chemical pyrolysis. To analyze the damage mechanism on sandwich structures of different materials, a finite element method (FEM) model to calculate the temperature and pressure distribution was built, taking into consideration heat transfer and flow expansion due to impulse currents. According to the simulation results, PVC had the most severe temperature and pressure distribution, while PET and balsa wood were in the better condition after the experiments. The temperature distribution results explained clearly why balsa wood suffered much less chemical pyrolysis than PVC. Since balsa wood had better thermal stability than PET, the pyrolysis area of PET was obviously larger than that of balsa wood too. Increasing the volume fraction of solid components of porous materials can efficiently decrease the heat transfer velocity in porous materials. Permeability didn’t influence that much. The findings provide support for optimum material selection and design in blade manufacturing.
Accessible Morphological and Genetic Markers for Identification of Taioba and Taro, Two Forgotten Human Foods
Authors: Sepúlveda-Nieto María , Bonifacio-Anacleto Fernando , Faleiros de Figueiredo Cairo , De Moraes-Filho Rômulo , Alzate-Marin Ana
Published: October 2017

Some tropical species—such as the domesticated Xanthosoma sagittifolium (L.) Schott (Taioba) and Colocasia esculenta (L.) Schott (Taro)—have similar phenotypic characteristics, especially in the shape and color of the leaves and petioles which generate uncertainty in their identification for use in human food. This study aimed to analyze the morphological and molecular characteristics of X. sagittifolium and C. esculenta that may help in the popular and scientific identification of these species. The principal morphological characteristics of X. sagittifolium were as follows: leaves with subcoriaceous textures, basal insertion of the petiole, green pseudo-stem in the basal portion with exudate being white and the presence of two collector veins. Distinctive morphological characteristics of C. esculenta were as follows: leaves with velvety textures, peltate insertion of the petiole, pink pseudo-stem in the basal portion with pink exudate and presence of one collector vein. The morphological characteristics that can be used to distinguish Taioba from Taro are the basal petiole insertion of the first, against the petiole insertion near the center of the blade of the latter. Molecular analyses using eight Inter-Simple Sequence Repeat (ISSR) molecular markers simultaneously showed distinctive fingerprints for each of the species. These results contribute to the proper identification of the species used as a food source.
A Combination of Immune Checkpoint Inhibition with Metronomic Chemotherapy as a Way of Targeting Therapy-Resistant Cancer Cells
Authors: Kareva Irina
Published: October 2017

Therapeutic resistance remains a major obstacle in treating many cancers, particularly in advanced stages. It is likely that cytotoxic lymphocytes (CTLs) have the potential to eliminate therapy-resistant cancer cells. However, their effectiveness may be limited either by the immunosuppressive tumor microenvironment, or by immune cell death induced by cytotoxic treatments. High-frequency low-dose (also known as metronomic) chemotherapy can help improve the activity of CTLs by providing sufficient stimulation for cytotoxic immune cells without excessive depletion. Additionally, therapy-induced removal of tumor cells that compete for shared nutrients may also facilitate tumor infiltration by CTLs, further improving prognosis. Metronomic chemotherapy can also decrease the number of immunosuppressive cells in the tumor microenvironment, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Immune checkpoint inhibition can further augment anti-tumor immune responses by maintaining T cells in an activated state. Combining immune checkpoint inhibition with metronomic administration of chemotherapeutic drugs may create a synergistic effect that augments anti-tumor immune responses and clears metabolic competition. This would allow immune-mediated elimination of therapy-resistant cancer cells, an effect that may be unattainable by using either therapeutic modality alone.
Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms
Authors: Dixit Aakanksha , Tanaka Akane , Greer Judith M. , Donnelly Sheila
Published: October 2017

The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend’s hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection. On this basis, the possibility of treating MS with helminth infection has been explored in animal models and phase 1 and 2 human clinical trials. However, the possibility also exists that the individual immune modulatory molecules secreted by helminth parasites may offer a more defined therapeutic strategy.
A Novel Grey Prediction Model Combining Markov Chain with Functional-Link Net and Its Application to Foreign Tourist Forecasting
Authors: Hu Yi-Chung , Jiang Peng , Chiu Yu-Jing , Tsai Jung-Fa
Published: October 2017

Grey prediction models for time series have been widely applied to demand forecasting because only limited data are required for them to build a time series model without any statistical assumptions. Previous studies have demonstrated that the combination of grey prediction with neural networks helps grey prediction perform better. Some methods have been presented to improve the prediction accuracy of the popular GM(1,1) model by using the Markov chain to estimate the residual needed to modify a predicted value. Compared to the previous Grey-Markov models, this study contributes to apply the functional-link net to estimate the degree to which a predicted value obtained from the GM(1,1) model can be adjusted. Furthermore, the troublesome number of states and their bounds that are not easily specified in Markov chain have been determined by a genetic algorithm. To verify prediction performance, the proposed grey prediction model was applied to an important grey system problem—foreign tourist forecasting. Experimental results show that the proposed model provides satisfactory results compared to the other Grey-Markov models considered.
The Decomposition Products of Sulfur Hexafluoride (SF6) with Metals Dissolved in Liquid Ammonia
Authors: Deubner Holger , Kraus Florian
Published: October 2017

Sulfur hexafluoride is a highly chemically inert gas with several important industrial applications. It is stable against fused alkali, oxygen and ammonia, even at several hundred degrees Celsius. In this work, the reactions between metals (Li–Cs, Sr, Ba, Eu, Yb) dissolved in liquid ammonia and SF6 are reported, leading to mono- or bivalent fluorides and sulfides. To this end, SF6 was passed into a cooled solution of the respective metal in liquid ammonia. The identity of the products was confirmed by powder X-ray diffraction and IR spectroscopy. The reactions could lead to a cheap and effective disposal method of the present amounts of stored SF6, for possible generation of H2S and HF.
Baseline Fusion for Image and Pattern Recognition—What Not to Do (and How to Do Better)
Authors: Arandjelović Ognjen
Published: October 2017

The ever-increasing demand for a reliable inference capable of handling unpredictable challenges of practical application in the real world has made research on information fusion of major importance; indeed, this challenge is pervasive in a whole range of image understanding tasks. In the development of the most common type—score-level fusion algorithms—it is virtually universally desirable to have as a reference starting point a simple and universally sound baseline benchmark which newly developed approaches can be compared to. One of the most pervasively used methods is that of weighted linear fusion. It has cemented itself as the default off-the-shelf baseline owing to its simplicity of implementation, interpretability, and surprisingly competitive performance across a widest range of application domains and information source types. In this paper I argue that despite this track record, weighted linear fusion is not a good baseline on the grounds that there is an equally simple and interpretable alternative—namely quadratic mean-based fusion—which is theoretically more principled and which is more successful in practice. I argue the former from first principles and demonstrate the latter using a series of experiments on a diverse set of fusion problems: classification using synthetically generated data, computer vision-based object recognition, arrhythmia detection, and fatality prediction in motor vehicle accidents. On all of the aforementioned problems and in all instances, the proposed fusion approach exhibits superior performance over linear fusion, often increasing class separation by several orders of magnitude.
Marine Sponge Natural Products with Anticancer Potential: An Updated Review
Authors: Calcabrini Cinzia , Catanzaro Elena , Bishayee Anupam , Turrini Eleonora , Fimognari Carmela
Published: October 2017

Despite the huge investment into research and the significant effort and advances made in the search for new anticancer drugs in recent decades, cancer cure and treatment continue to be a formidable challenge. Many sources, including plants, animals, and minerals, have been explored in the oncological field because of the possibility of identifying novel molecular therapeutics. Marine sponges are a prolific source of secondary metabolites, a number of which showed intriguing tumor chemopreventive and chemotherapeutic properties. Recently, Food and Drug Administration-approved drugs derived from marine sponges have been shown to reduce metastatic breast cancer, malignant lymphoma, and Hodgkin’s disease. The chemopreventive and potential anticancer activity of marine sponge-derived compounds could be explained by multiple cellular and molecular mechanisms, including DNA protection, cell-cycle modulation, apoptosis, and anti-inflammatory activities as well as their ability to chemosensitize cancer cells to traditional antiblastic chemotherapy. The present article aims to depict the multiple mechanisms involved in the chemopreventive and therapeutic effects of marine sponges and critically explore the limitations and challenges associated with the development of marine sponge-based anticancer strategy.
Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity, Antioxidant Properties, Phenolic Content and Amino Acid Profiles of Fucus spiralis L. Protein Hydrolysate Fractions
Authors: Paiva Lisete , Lima Elisabete , Neto Ana , Baptista José
Published: October 2017

Food protein-derived hydrolysates with multi-bioactivities such as antihypertensive and antioxidant properties have recently received special attention since both activities can play significant roles in preventing cardiovascular diseases. This study reports, for the first time, the angiotensin I-converting enzyme (ACE)-inhibition and antioxidant properties of ultrafiltrate fractions (UF) with different molecular weight ranges (<1, 1–3 and ≥3 kDa) obtained from Fucus spiralis protein hydrolysate (FSPH) digested with cellulase–bromelain. The amino acids profile, recovery yield, protein, peptide and total phenolic contents of these FSPH-UF, and the in vitro digestibility of F. spiralis crude protein were also investigated. FSPH-UF ≥3 kDa presented remarkably higher ACE-inhibition, yield, peptide and polyphenolic (phlorotannins) contents. Antioxidant analysis showed that FSPH-UF <1 kDa and ≥3 kDa exhibited significantly higher scavenging of 2,2-diphenyl-1-picrylhydrazyl radical and ferrous ion-chelating (FIC) activity. FSPH-UF ≥3 kDa had also notably higher ferric reducing antioxidant power (FRAP). Strong correlations were observed between ACE-inhibition and antioxidant activities (FIC and FRAP). The results suggest that ACE-inhibition and antioxidant properties of FSPH-UF may be due to the bioactive peptides and polyphenols released during the enzymatic hydrolysis. In conclusion, this study shows the potential use of defined size FSPH-UF for the prevention/treatment of hypertension and/or oxidative stress-related diseases.
Development of Metallographic Etchants for the Microstructure Evolution of A6082-T6 BFSW Welds
Authors: Tamadon Abbas , Pons Dirk , Sued Kamil , Clucas Don
Published: October 2017

BACKGROUND—The solid-phase joining of A6082-T6 plates by bobbin friction stir welding (BFSW) is problematic. Better methods are needed to evaluate the microstructural evolution of the weld. However, conventional Al reagents (e.g., Keller’s and Kroll’s) do not elucidate the microstructure satisfactorily, specifically regarding grain size and morphology within the weld region. APPROACH—We developed innovative etchants for metallographic observations for optical microscopy. RESULTS—The macrostructure and microstructure of A6082-T6 BFSW welds were clearly demonstrated by optical microscopy analysis. The microetching results demonstrated different microstructures of the Stir Zone (S.Z) distinct from the Base Metal (B.M) and Heat Affected Zone (HAZ) & Thermo-mechanical Affected Zone (TMAZ). The micrographs showed a significant decrease in grain size from 100 μm in B.M to ultrafine 4–10 μm grains for the S.Z. Also, the grain morphology changed from directional columnar in the B.M to equiaxed in the S.Z. Furthermore, thermomechanical recrystallization was observed by the morphological flow of the grain distortion in HAZ and TMAZ. The etchants also clearly show the polycrystalline structure, microflow patterns, and the incoherent interface around inclusion defects. ORIGINALITY—Chemical compositions are identified for a suite of etchant reagents for metallographic examination of the friction-stir welded A6082-T6 alloy. The reagents have made it possible to reveal microstructures not previously evident with optical microscopy.
Study on Ti-6Al-4V Alloy Machining Applying the Non-Resonant Three-Dimensional Elliptical Vibration Cutting
Authors: Lu Mingming , Zhou Jiakang , Lin Jieqiong , Gu Yan , Han Jinguo , Zhao Dongpo
Published: October 2017

The poor machinability of Ti-6Al-4V alloy makes it hard to process by conventional processing methods even though it has been widely used in military and civilian enterprise fields. Non-resonant three-dimensional elliptical vibration cutting (3D-EVC) is a novel cutting technique which is a significant development potential for difficult-to-cut materials. However, few studies have been conducted on processing the Ti-6Al-4V alloy using the non-resonant 3D-EVC technique, the effect of surface quality, roughness, topography and freeform surface has not been clearly researched yet. Therefore, the machinability of Ti-6Al-4V alloy using the non-resonant 3D-EVC apparatus is studied in this paper. Firstly, the principle of non-resonant 3D-EVC technique and the model of cutter motion are introduced. Then the tool path is synthesized. The comparison experiments are carried out with traditional continuous cutting (TCC), two-dimension elliptical vibration cutting (2D-EVC), and the non-resonant 3D-EVC method. The experimental results shown that the excellent surface and lower roughness (77.3 nm) could be obtained using the non-resonant 3D-EVC method; the shape and dimension of elliptical cutting mark also relates to the cutting speed and vibration frequency, and the concave/convex spherical surface topography are achieved by non-resonant 3D-EVC in the Ti-6Al-4V alloy. This proved that the non-resonant 3D-EVC technique has the better machinability compared with the TCC and 2D-EVC methods.
A Process Mineralogy Approach to Gravity Concentration of Tantalum Bearing Minerals
Authors: Ghorbani Yousef , Fitzpatrick Rob , Kinchington Melanie , Rollinson Gavyn , Hegarty Patrick
Published: October 2017

The historic Penouta mine in northwest Spain is the focus of efforts to extract tantalum from tin mining waste. This paper describes the characterisation of the tantalum mineralogy of waste material from the deposit. Characterisation was realised using quantitative mineralogy and geochemistry. This paper further identifies other phases of interest and investigates the potential for extraction using gravity separation techniques. The gravity concentrate obtained through these tests was analysed using quantitative mineralogy and electron probe microanalysis. Following characterisation of the sample material to identify the key Ta-bearing mineral phases and assess liberation, a series of gravity separation trials were conducted using Heavy Liquid Separation (HLS), Mozley table, Knelson concentrator separation and shaking table. The laboratory shaking table used to conduct a rougher test and a rougher/cleaner test to simulate a spiral-table circuit using the Penouta material. Mass balance calculations were carried out to calculate the contained metal content of the feed material and concentrate products in order to assess recovery rates for Ta, Sn and Nb across a range of grains sizes. Ta was found to be present predominantly in the solid-solution columbite-group mineral, along with minor Ta present as microlite and as impurities within cassiterite. It was found that over 70% of the Ta is contained within the −125 μm fraction, with the Ta-bearing minerals tantalite and microlite being closely associated with quartz. Mozley table separation resulted in recoveries of 89% Ta and 85% Nb for the −125 μm fraction. The Knelson Concentrator trial was carried out on the −625 μm size fraction, thereby eliminating low grade material found in the coarsest fractions. Size analysis of the recovery rate for each product, shows that the Knelson concentrator is most efficient for recovery of −125 μm particles.
Binding Direction-Based Two-Dimensional Flattened Contact Area Computing Algorithm for Protein–Protein Interactions
Authors: Kang Beom , Pugalendhi GaneshKumar , Kim Ku-Jin
Published: October 2017

Interactions between protein molecules are essential for the assembly, function, and regulation of proteins. The contact region between two protein molecules in a protein complex is usually complementary in shape for both molecules and the area of the contact region can be used to estimate the binding strength between two molecules. Although the area is a value calculated from the three-dimensional surface, it cannot represent the three-dimensional shape of the surface. Therefore, we propose an original concept of two-dimensional contact area which provides further information such as the ruggedness of the contact region. We present a novel algorithm for calculating the binding direction between two molecules in a protein complex, and then suggest a method to compute the two-dimensional flattened area of the contact region between two molecules based on the binding direction.
Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation
Authors: Sun Yating , Zhao Yarong , Zhao Xiuting , Lee Robert J. , Teng Lesheng , Zhou Chenguang
Published: October 2017

Oligonucleotide (ON) drugs, including small interfering RNA (siRNA), microRNA (miRNA) and antisense oligonucleotides, are promising therapeutic agents. However, their low membrane permeability and sensitivity to nucleases present challenges to in vivo delivery. Chemical modifications of the ON offer a potential solution to improve the stability and efficacy of ON drugs. Combined with nanoparticle encapsulation, delivery at the site of action and gene silencing activity of chemically modified ON drugs can be further enhanced. In the present review, several types of ON drugs, selection of chemical modification, and nanoparticle-based delivery systems to deliver these ON drugs are discussed.
A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK)
Authors: Yan Yan , Gu Xin , Xu H. Eric , Melcher Karsten
Published: October 2017

While many methods exist to quantitatively determine protein kinase activities, 32P-based radioactive assays remain the workhorse of many laboratories due to their high sensitivity, high signal to noise ratio, lack of interference by fluorescent and light-absorbing small molecules, and easy quantitation. Here, we demonstrate that the interaction between the yeast Rad53 Forkhead-associated (FHA) domain and a peptide optimized for phosphorylation by AMP-Activated Protein Kinase (AMPK), which has previously been exploited for the generation of intracellular phosphorylation sensors, can serve as a readout for a highly sensitive two-step AMPK AlphaScreen kinase assay with exceptional signal-to-noise ratio.
Porcine Dental Epithelial Cells Differentiated in a Cell Sheet Constructed by Magnetic Nanotechnology
Authors: Koto Wataru , Shinohara Yoshinori , Kitamura Kazuyuki , Wachi Takanori , Makihira Seicho , Koyano Kiyoshi
Published: October 2017

Magnetic nanoparticles (MNPs) are widely used in medical examinations, treatments, and basic research, including magnetic resonance imaging, drug delivery systems, and tissue engineering. In this study, MNPs with magnetic force were applied to tissue engineering for dental enamel regeneration. The internalization of MNPs into the odontogenic cells was observed by transmission electron microscopy. A combined cell sheet consisting of dental epithelial cells (DECs) and dental mesenchymal cells (DMCs) (CC sheet) was constructed using magnetic force-based tissue engineering technology. The result of the iron staining indicated that MNPs were distributed ubiquitously over the CC sheet. mRNA expression of enamel differentiation and basement membrane markers was examined in the CC sheet. Immunostaining showed Collagen IV expression at the border region between DEC and DMC layers in the CC sheet. These results revealed that epithelial–mesenchymal interactions between DEC and DMC layers were caused by bringing DECs close to DMCs mechanically by magnetic force. Our study suggests that the microenvironment in the CC sheet might be similar to that during the developmental stage of a tooth bud. In conclusion, a CC sheet employing MNPs could be developed as a novel and unique graft for artificially regenerating dental enamel.
Vitamin D and Age-Related Macular Degeneration
Authors: Layana Alfredo , Minnella Angelo , Garhöfer Gerhard , Aslam Tariq , Holz Frank , Leys Anita , Silva Rufino , Delcourt Cécile , Souied Eric , Seddon Johanna
Published: October 2017

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.
Fabrication and Characterization of a Stabilized Thin Film Ag/AgCl Reference Electrode Modified with Self-Assembled Monolayer of Alkane Thiol Chains for Rapid Biosensing Applications
Authors: Rahman Tanzilur , Ichiki Takanori
Published: October 2017

The fabrication of miniaturized electrical biosensing devices can enable the rapid on-chip detection of biomarkers such as miRNA molecules, which is highly important in early-stage cancer detection. The challenge in realizing such devices remains in the miniaturization of the reference electrodes, which is an integral part of electrical detection. Here, we report on a novel thin film Ag/AgCl reference electrode (RE) that has been fabricated on top of a Au-sputtered glass surface, which was coated with a self-assembled monolayer (SAM) of 6-mercepto-1-hexanol (MCH). The electrode showed very little measurement deviation (−1.5 mv) from a commercial Ag/AgCl reference electrode and exhibited a potential drift of only ± 0.2 mV/h. In addition, the integration of this SAM-modified microfabricated thin film RE enabled the rapid detection (<30 min) of miRNA (let-7a). The electrode can be integrated seamlessly into a microfluidic device, allowing the highly stable and fast measurement of surface potential and is expected to be very useful for the development of miniature electrical biosensors.
Plasmonic Nanomaterial-Based Optical Biosensing Platforms for Virus Detection
Authors: Lee Jaewook , Takemura Kenshin , Park Enoch
Published: October 2017

Plasmonic nanomaterials (P-NM) are receiving attention due to their excellent properties, which include surface-enhanced Raman scattering (SERS), localized surface plasmon resonance (LSPR) effects, plasmonic resonance energy transfer (PRET), and magneto optical (MO) effects. To obtain such plasmonic properties, many nanomaterials have been developed, including metal nanoparticles (MNP), bimetallic nanoparticles (bMNP), MNP-decorated carbon nanotubes, (MNP-CNT), and MNP-modified graphene (MNP-GRP). These P-NMs may eventually be applied to optical biosensing systems due to their unique properties. Here, probe biomolecules, such as antibodies (Ab), probe DNA, and probe aptamers, were modified on the surface of plasmonic materials by chemical conjugation and thiol chemistry. The optical property change in the plasmonic nanomaterials was monitored based on the interaction between the probe biomolecules and target virus. After bioconjugation, several optical properties, including fluorescence, plasmonic absorbance, and diffraction angle, were changed to detect the target biomolecules. This review describes several P-NMs as potential candidates of optical sensing platforms and introduces various applications in the optical biosensing field.
Configurational Paths to Social Performance in SMEs: The Interplay of Innovation, Sustainability, Resources and Achievement Motivation
Authors: Kraus Sascha , Burtscher Janina , Niemand Thomas , Roig-Tierno Norat , Syrjä Pasi
Published: October 2017

In today’s world of increasing ecological, social and economic issues, the question as to how businesses can become a vehicle towards more sustainable development has become more relevant than ever. Crucial to a more sustainable economy is the successful implementation of sustainable practices through entrepreneurial activities. Although there are attempts to describe how sustainable entrepreneurs differentiate themselves, the question of how some entrepreneurs manage to successfully create a sustainable enterprise, while others do not, remains unanswered. The aim of this research is to find causal patterns that explain the success of sustainable entrepreneurs, using their social performance as a measure. Using a configuration approach-based fuzzy set qualitative comparative analysis (fsQCA) of 598 Austrian small- and medium-sized enterprises (SMEs), we could identify four different combinations of the interconnected variables of innovation orientation, environmental sustainability, resource leveraging and achievement motivation, which all lead to social performance depending on the respective networking intensity of the firms. The only variable that is included in all combinations is environmental sustainability, thus indicating it may be either crucial to or a prerequisite for achieving social performance in SMEs.
Sustainability as Practice: Reflections on the Creation of an Institutional Logic
Authors: Silva Minelle , Figueiredo Marina
Published: October 2017

Debates over social and organisational sustainability are constant because sustainability must stem from beliefs and goals that social and economic actors share. However, there is still a gap in the knowledge about how sustainability is practiced. In this theoretical paper, we use institutional logic (IL) to assume that the logic of sustainability can contribute to sustainability studies by explaining how practices are socially constructed and shared among actors. We consider sustainability as a practice by articulating IL through an understanding of practice-based studies (PBS). Sustainability as a practice facilitates the emergence of new organisational values and contributes to changes that support a new institutional logic. Hence, we define the institutional logic of sustainability (ILS) as a theoretical approach enabling comprehension of how sustainability can be observed and practiced through socially constructed actions and intentions. We highlight its relevance to deep sustainability studies and argue that by using different roles and meanings surrounding its performance, sustainability as a practice can facilitate studies about organisations.
Assessment of Phosphorus Recovery from Swine Wastewater in Beijing, China
Authors: Wang Qiming , Zhang Tao , He Xinyue , Jiang Rongfeng
Published: October 2017

The nutrient management of phosphorus (P) contained in swine wastewater is an important challenge to enhance P use efficiency. In the present study, assessment of P recovery from swine wastewater in Beijing was performed. P amounts of swine wastewater increased from 11,687 tons in 1980 to 16,237 tons in 2014. Without treatment of swine wastewater, P concentration will reach a maximum 1.20 mg/L. The maximum P recovery was 99.36% under the condition of crystallization coupled BPR (biological phosphorus removal) when the operating conditions were 60.6 mg/L for Cp (initial P concentration (mg/L)), 1.2 for Mg/P (magnesium-to-P molar ratio), 9.7 for pH of crystallization process, and 8.0 for pH, 1.6 h for anaerobic stage time, 15 days for sludge retention time of BPR. The P concentration for water quality was 0.03 mg/L to meet the water regulation standard. Under this situation, if the target P concentration were set as Grade II and III, pig breeding numbers reached 42.07 and 95.90 million heads. Construction investments for the crystallization, BRP, and coupled methods are 411 (104 Yuan, 604,307 USD), 301 (104 Yuan, 442,580 USD), and 551 (104 Yuan, 810,170 USD), respectively. The running costs are 15.205 (104 Yuan/year, 22,360 USD/year), 28.907 (104 Yuan/year, 42,500 USD/year) and 44.112 (104 Yuan/year, 64,860 USD/year). To manage non-point pollution, swine wastewater treatment facilities should be used and pig breeding numbers should be managed within reasonable ranges.
Magnetic Transport in Spin Antiferromagnets for Spintronics Applications
Authors: Azzouz Mohamed
Published: October 2017

Had magnetic monopoles been ubiquitous as electrons are, we would probably have had a different form of matter, and power plants based on currents of these magnetic charges would have been a familiar scene of modern technology. Magnetic dipoles do exist, however, and in principle one could wonder if we can use them to generate magnetic currents. In the present work, we address the issue of generating magnetic currents and magnetic thermal currents in electrically-insulating low-dimensional Heisenberg antiferromagnets by invoking the (broken) electricity-magnetism duality symmetry. The ground state of these materials is a spin-liquid state that can be described well via the Jordan–Wigner fermions, which permit an easy definition of the magnetic particle and thermal currents. The magnetic and magnetic thermal conductivities are calculated in the present work using the bond–mean field theory. The spin-liquid states in these antiferromagnets are either gapless or gapped liquids of spinless fermions whose flow defines a current just as the one defined for electrons in a Fermi liquid. The driving force for the magnetic current is a magnetic field with a gradient along the magnetic conductor. We predict the generation of a magneto-motive force and realization of magnetic circuits using low-dimensional Heisenberg antiferromagnets. The present work is also about claiming that what the experiments in spintronics attempt to do is trying to treat the magnetic degrees of freedoms on the same footing as the electronic ones.