bluuebunny/crossref_metadata_2025 huggingface dataset:
Key markers of ferroptosis
Authors: Tokhtueva M.D. , Melekhin V.V.
Published: August 2024

Introduction. Ferroptosis is a type of programmed cell death associated with excessive accumulation of endogenous iron in the cell, accompanied by the production of reactive oxygen species and, as a result, lipid peroxidation. The literature review examines the key markers of ferroptosis, which is one of the types of programmed cell death other than apoptosis, necroptosis, pyroptosis, etc. Purpose: to collect and process information on the main markers of ferroptosis, which will allow to adapt and optimize the processes of its study. Material and methods: analysis of literary sources of domestic and foreign origin on a given topic. Results: articles have been found and analyzed, including those from the last 5 years, confirming the prospects of ferroptosis as a potential pharmacological target. Conclusion. Understanding the main signs of the launch of this process is an integral part of the research work aimed at finding new therapeutic targets associated with the launch of ferroptosis, which, in turn, represents a promising pharmacological model, since It has a high potential for the future treatment of drug-resistant types of pathologies.
DACARBAZINE INITIATES SIRT1-INDEPENDENT OVEREXPRESSION OF ANTI-APOPTOTIC BCL2 IN MELANOMA CELLS IN VIVO
Authors: Lapkina E.Z. , Kutsenko V.A. , Ruksha T.G.
Published: August 2024

Introduction. Cancer cell drug resistance in melanoma is associated with evasion of apoptosis-induced stimuli. Assessing the level of expression of the BCL2 and SIRT1 genes in distant organs and the tumor node makes it possible to assess the resistance of melanoma cells to chemotherapeutic effects associated with the activation of anti-apoptotic mechanisms. The aim of the study. Relative expression level of the SIRT1 and BCL2 estimation in the tumor node and target organs for distant metastatic (lungs, liver) in B16 melanoma bearing mice under dacarbazine treatment. Methods. In the in vivo model of B16 melanoma. Intraperitoneal administration of dacarbazine was used in vivo. Subsequently, total RNA was extracted from the cells of tumor node and distant organs (liver, lungs). Relative expression levels of the apoptosis and cell proliferation genes SIRT1, BCL2 were analyzed using real-time PCR (RT-PCR) method. Results. When exposed to dacarbazine, the relative level of expression of the anti-apoptotic BCL2 in the tumor in B16 melanoma increases by 5.7-fold. The relative expression level of SIRT1 in the lungs after intraperitoneal injections of dacarbazine decreased by 3.8-fold.; in the liver of mice, the relative expression level of SIRT1 increased by 1.94-fold. The relative level of BCL2 expression in the lungs after intraperitoneal injections of dacarbazine decreased by 31-fold. In mouse liver, the relative expression level of BCL2 increased 1.94-fold. Conclusion. When exposed to dacarbazine as a damaging factor in skin melanoma in vivo, SIRT1-mediated protection against apoptosis of liver cells and SIRT1-mediated activation of apoptosis in lung tissue cells of mice can be replaced, while in the melanoma tumor cell a pattern of SIRT1-independent induction of anti-apoptotic processes by dacarbazine in B16 melanoma bearing mice under dacarbazine treatment.
DIFFERENT CONCENTRATIONS OF PEROXYNITRITE CAUSE A UNIQUE CELLULAR RESPONSE OF ENDOTHELIOCYTES IN VITRO
Authors: Korotkova N.V. , Kalinin R.E. , Suchkov I.A. , Zakharov A.S. , Mzhavanadze N.D. , Nikiforov A.А.
Published: August 2024

Introduction. The study of the effect of peroxynitrite, as a product of nitric oxide (II), on the culture of endothelial cells in vitro can contribute to fundamental ideas about the violation of the adhesive function of the endothelium when changing the synthesis of nitric oxide. The aim of the study. To study the effect of peroxynitrite in various concentrations on the metabolic and migration activity of endotheliocytes, as well as on the expression of endothelium-specific proteins-selectin Р and Е, as an indicator of the adhesive function of the endothelium. Methods. The cytotoxicity of peroxynitrite in various concentrations was assessed using the MTT test. The migration and proliferative activity of endotheliocytes was studied by a scratch test. The concentration of sP- and sЕ-selectins was determined using the ELISA sandwich method in the supernatant of endotheliocytes culture. Results. A statistically significant increase in the metabolic activity of endothelial cells was revealed during a 30-minute incubation with peroxynitrite at concentrations of 0,0025, 0,0075 and 0,01 mM. A statistically significant decrease in the migration activity of endothelial cells was revealed after a 30-minute incubation with peroxynitrite at concentrations of 0,0025 and 0,1 mM, both in the first 12 and within 24 hours. A multidirectional effect of peroxynitrite at various concentrations on the level of sP and sE selectins in the cell culture supernatant was revealed: a statistically significant decrease in sE-selectin after 30-minute incubation with peroxynitrite solutions at concentrations of 0,0025, 0,1 and 1,0 mM; as well as a statistically significant increase in sP-selectin during 30-minute incubation with peroxynitrite solutions of 0,0025 and 0,1 mM. Conclusion. Peroxynitrite for endothelial cells can act as a signaling molecule, stimulating or suppressing mitochondrial and migratory activity, and also as a cytotoxic agent, causing cell death. In addition, at various concentrations it is capable of influencing either the synthesis of endothelium-specific selectin proteins or the proteolytic shedding of the extracellular domains of these proteins, which requires further study.
Kimmerle anomaly: modern approaches to diagnosis and treatment
Authors: Yarikov A. , Makeeva O. , Kornakova O. , Fraerman A. , Perlmutter O. , Zaletova I. , Shigorina A. , Zolnikova A. , Sharova V. , Levshakov V. , Khavanskaya E. , Smolin A. , Shlykova M. , Мarychev D. , Medvedeva M. , Kalinkin A. , Pardaev S.
Published: August 2024

Kimmerle anomaly is a variant of the first cervical vertebra, which is an additional bony arch extending from the posterolateral part of the lateral mass of the atlas above the furrow of the vertebral artery to the posterior arch, as well as ossification of part of the Atlanto-occipital ligament. The article presents general information about the Kimmerli anomaly. The work describes in detail the epidemiology, clinical picture, pathogenesis, diagnosis of this disease. Aspects of modern methods of treatment are also considered: from conservative to various surgical methods.
"Working pensioner" status as a factor reducing the risk of age-associated diseases
Authors: Kobelev I. , Rukavishnikov N.
Published: August 2024

Some people of retirement age continue to work today, which motivates domestic scientists to study the characteristics of their health status.
Рurpose. To study the ratio of working pensioners and non-working pensioners in the context of age-associated diseases.
Materials and methods. The materials used were accounting and reporting documentation on the issuance of certificates of incapacity for work in the St. Petersburg State Budgetary Healthcare Institution “City Multidisciplinary Hospital №2” from 01.01.2019 to 12.31.2023. The study included patients over working age hospitalized for cardiological, ophthalmological and endocrinological diseases.
Results. The data obtained indicate that the ratio of working pensioners to non-working ones remained approximately the same in both the pre-COVID (2019) and post-COVID (2022–2023) periods. Moreover, this ratio remained stable even during the COVID period (2020–2021). According to Rosstat, among the population over working age, the ratio of the number of working pensioners to the number of non-working people was 0.25, which is statistically significantly (p<0.05) different from the same indicator among patients of a comparable age category with age-related diseases.
Conclusion. A protective effect of the status of a “working pensioner” was discovered in terms of reducing the risk of developing age-associated diseases. From 2019 to 2022 There was a downward trend in the share of employed people over working age.
UPAYA PENINGKATAN KESEHATAN SISWA SD NEGERI 2 SENGGIGI MELALUI PROGRAM : “KENALI MAKANMU, JAGA KESEHATANMU”
Authors: Arhya Putra Made Raditya , Octora Metta , Abdiman I Made Tobias , Putri Atina Rizki , Hazaa Saskia Safarinaa , Farras Afif , Sholihatin Illiyani , Nurhaliza Siti , Kadarisma Shofia , Putra Yusril Sani Riandika , Ginuluh Gintis Dhimar , Hayaza Safira Said , Retnaningsih Ekawaty , Mujahid Sabila Izzatina Azmy , Makbul Ini Hidayat , Hardyningrat Baiq Inna Dwi , Kirana Devi Chandra , Nugraha Kadek Nandita , Ishlahi Salsabila Dinda Nuril , Yahya Najla Aulia , Amanullah Mohammad Sany Rosafi
Published: August 2024

Jajanan yang dijual di lingkungan sekolah memiliki peranan penting dalam pemenuhan zat gizi yang baik bagi siswa sekolah dasar. Saat ini, masih banyak pedagang yang tidak memperhatikan jajanan yang dijual baik dari jenis, komposisi, dan kebersihan. Berdasarkan data BPOM, sekitar 39,96% jajanan yang tidak memenuhi syarat untuk dikonsumsi yang tersebar di seluruh Indonesia. Hal ini menunjukkan betapa pentingnya siswa sekolah untuk mengenal dan memilih jajanan di area sekolah. Hal Ini pula mendasari dilakukannya penyuluhan mengenai jajanan sehat di lingkungan sekolah di daerah Senggigi Kabupaten Lombok Barat sebagai sekolah dasar binaan Fakultas Kedokteran Universitas Mataram. Penyuluhan dilakukan pada siswa-siswi kelas 1 dan 2 SDN 2 Senggigi dilakukan hari Jumat, 1 September 2023 pukul 09.00 â€“ 10.00 WITA. Bentuk kegiatan penyuluhan meliputi pemberian materi penyuluhan mengenai jajanan sehat, menyanyikan lagu jajanan sehat, pre dan post-test, games jajanan sehat, cara mencuci tangan yang benar serta pemberian buah-buahan. Pengolahan data hasil pre dan post-test dilakukan dengan aplikasi SPSS dan didapatkan ada perubahan rerata nilai pengetahuan siswa sebelum dan sesudah penyuluhan jajanan sehat.
COMPARAÇÃO DE DESEMPENHO DE ABORDAGENS DE APRENDIZADO DE MÁQUINA EM UM BANCO DE DADOS REAL SOBRE HEPATITE C (HCV DATA)
Authors: DURAND ANALUIZA BATISTA , CARVALHO LAÍS MARIA SILVA DE
Published: August 2024

Resumo: A Hepatite C, um vírus pertencente ao gênero Hepacivirus da família Flaviviridae, é uma das principais causas
de doenças hepáticas, podendo resultar em hepatite aguda ou crônica. Seu genoma consiste em um RNA de polaridade
positiva, com uma estrutura esférica e diâmetro de cerca de 50mm. A transmissão ocorre principalmente por via parenteral,
mas também por relações sexuais não protegidas e transmissão vertical. A pesquisa médica enfrenta o desafio de
diagnósticos e tratamentos precisos, e a aprendizagem de máquina (ML) tem emergido como uma ferramenta útil.
Objetivo: comparar algoritmos em softwares diferentes aplicados a um banco de dados real. Metodologia: O conjunto
de dados HCV DATA contém informações laboratoriais e demográficas de doadores de sangue e pacientes com hepatite
C. O estudo envolveu três etapas: descrição e pré-processamento dos dados, aplicação de modelos de ML com diferentes
parâmetros e avaliação do desempenho dos modelos através de métricas como a matriz de confusão, coeficiente Kappa e
recall. Resultados e discussão: O algoritmo Regra de Bayes (FuzzyBayesRule) foi testado com diferentes porcentagens
de split, resultando em coeficientes Kappa entre 0,4983 e 0,61 e acurácia entre 0,8065 e 0,8943. A comparação com Naive
Bayes e Árvore de Decisão mostrou que o modelo Regra de Bayes apresentou boa capacidade de identificação de
exemplos positivos e estabilidade em diferentes configurações de cross-validation e percentage split. Considerações
Finais: Em conclusão, a análise abrangente dos resultados destaca a importância de avaliar o desempenho dos modelos
em várias métricas e contextos. Enquanto o modelo Regra de Bayes mostrou capacidade de previsão precisa, ele também
enfrentou desafios em algumas classes. O estudo demonstra o potencial do aprendizado de máquina na medicina, mas
também a complexidade de lidar com cenários heterogêneos.
Palavras-chaves: Hepatite C. Algoritmo. Fuzzy. Regra de Bayes
CONSCIENTIZAÇÃO SOBRE O CÂNCER DE MAMA NAS EMPRESAS
Authors: FREITAS YURI COSTA DE , FERREIRA ARTHUR HENRIQUE ARAÚJO , MARTINS MARIANA DA ROCHA , DAMASCENO LORRANY JHESSY DE JESUS , VASCONCELOS ALICE RAQUEL DE CARVALHO , MARTINS CLÁUDIA MARIA DA ROCHA , SILVA JOSÉ HENRIQUE SANTOS
Published: August 2024

Resumo: O câncer de mama é o tipo mais comum entre mulheres em todo o mundo e a principal causa de morte por
câncer em mulheres no Brasil. Nesse contexto, as estratégias de conscientização e prevenção desempenham um papel
crucial. Objetivo: Descrever a experiência de graduandos da área da saúde em palestras de conscientização sobre o câncer
de mama realizadas em empresas durante a campanha do Outubro Rosa de 2023. Materiais e métodos: Trata-se de um
estudo descritivo, do tipo relato de experiência, conduzido por uma Liga Acadêmica Multidisciplinar em Oncologia no
Norte do Brasil. As atividades foram realizadas ao longo do mês de outubro de 2023, focando na prevenção do câncer de
mama no ambiente corporativo. Resultados e discussão: Foram realizadas 13 palestras, onde os participantes
demonstraram maior reconhecimento sobre a importância da detecção precoce do câncer de mama e adquiriram
conhecimento sobre o autoexame das mamas e da mamografia, conforme orientações do Instituto Nacional de Câncer.
Esses resultados sugerem que a educação em saúde nas empresas pode ser uma estratégia eficaz para disseminar
informações cruciais e incentivar práticas de autocuidado. Considerações finais: Consideramos que as iniciativas de
conscientização nas empresas não só capacitam os indivíduos a cuidar de sua saúde, mas também os habilitam a
influenciar positivamente seus círculos sociais, aumentando o impacto das ações preventivas. Destacamos o papel crucial
das atividades das ligas acadêmicas multidisciplinares de oncologia na promoção da saúde da população.
Palavras-chave: Conscientização; Empresas e Organizações de Serviço; Neoplasias da Mama
EXERCÍCIO FÍSICO NO TRATAMENTO DA DOR ONCOLÓGICA: UMA REVISÃO BIBLIOGRÁFICA SOBRE OS EFEITOS DAS INTERVENÇÕES FISIOTERAPÊUTICAS EM SOBREVIVENTES DE CÂNCER
Authors: SALES MATHEUS DE CASTRO , BARROS BÁRBARA VASCONCELLOS FREIRE DE , LIMA ISABELI HANNA CARNEIRO , MONTENEGRO GLÓRIA MARIA FARIAS , COSTA RAYANA FIALHO DA , CAMPOS NATALY GURGEL
Published: August 2024

Resumo: O câncer (CA) é caracterizado pelo crescimento desordenado de células que leva à formação de tumores. A dor,
sintoma comum no câncer, normalmente é manejada com uso de opiáceos e anti-inflamatórios, que possuem diversos
efeitos colaterais. Objetivo: Investigar e descrever as evidências mais recentes relacionadas ao tratamento da dor
oncológica por meio do exercício físico. Materiais e métodos: Trata-se de uma revisão bibliográfica. Os artigos foram
coletados na base de dados PEDro com os descritores "cancer pain" e "exercise therapy". Avaliou-se apenas estudos
clínicos publicados entre 2014 e 2024 que possuíssem o desfecho dor em sua análise. Resultados e discussão: Foram
adicionados 12 estudos para avaliação, sendo sua maioria (10) acerca do CA de mama. A nota PEDro média dos trabalhos
foi de 5,58 pontos. Notou-se melhora significativamente relevante (p < 0,05) da dor nos pacientes submetidos a alguma
modalidade de exercício físico, a qual foi estendida à pacientes submetidas à mastectomia e terapia hormonal para o CA
de mama. Além disso, é possível que sobreviventes do CA de coluna e cabeça e pescoço se beneficiem do mesmo efeito
analgésico do exercício. Considerações finais: O exercício demonstrou ser uma excelente ferramenta para o tratamento
da dor oncológica, entretanto pela falta de padronização dos trabalhos avaliados, é necessário que se façam estudos mais
aprofundados acerca do tema para o estabelecimento do protocolo de exercício físico em pacientes com CA.
Palavras-chave: Exercício; Dor Oncológica; Fisioterapia.
HPV E NEOPLASIAS INTRAEPITELIAIS CERVICAIS
Authors: LIMA SARAH DOS SANTOS TEIXEIRA DE , CAMARGO GABRIELA MIRANDA DE , TORRES LUDMILA SILVA , GONÇALVES ARIANE BORGES , SANTANA REBECA LEITE SILVA , SALGADO ANDRESSA , BAGATIM VANESSA DO CARMO , AVELINO AMANDA BAGATIM , CASEMIRO LARA MARTINS , DAMASO ENIO LUIS
Published: August 2024

Resumo: As neoplasias intraepiteliais cervicais (NICs) são lesões proliferativas no colo do útero que podem evoluir para
câncer. O HPV é encontrado em mais de 99% dos casos de câncer do colo do útero, sendo os subtipos 16 e 18 os mais
oncogênicos. A vacinação contra o HPV é a melhor forma de prevenção. O diagnóstico das NICs é feito através do exame
citopatológico (Papanicolau) e seu tratamento varia de acordo com a classificação. Objetivo: Analisar a relação entre a
infecção por HPV e desenvolvimento das NICs, bem como relatar sua patogenia e classificação. Materiais e métodos:
Realizou-se revisão sistemática da literatura, baseando-se em artigos científicos indexados nas bases de dados Scielo e
PubMed, em inglês e português, nos últimos dez anos. A primeira exportação gerou 85 resultados, que foram exportados
para a plataforma Rayyan e analisados por dois revisores independentes. Após exclusão das duplicatas, artigos pagos e
documentos que não se relacionassem com a temática, 8 documentos foram revisados integralmente. Resultados e
discussão: O HPV infecta as células imaturas da camada basal do epitélio escamoso, replicando-se concomitantemente à
maturação desse epitélio. A infecção pelo HPV interfere nas proteínas supressoras tumorais, promovendo o crescimento
das células e dificultando a reparação do DNA. No entanto, outros fatores de risco também estão relacionados ao
desenvolvimento do câncer. As NICs são classificadas em NIC 1, NIC 2 e NIC 3. Para fins clínicos, são subdivididas em
apenas duas categorias: Lesão intraepitelial de baixo grau (LSIL) para NIC I e Lesão intraepitelial de alto grau NIC II e
NIC III. LSIL são tratadas de maneira conservadora, enquanto NIC II e III requer tratamento com excisão cirúrgica
(biópsia em cone). Considerações finais: É importante destacar que mais da metade dos casos de câncer de colo do útero
ocorre em mulheres que não realizam o exame de Papanicolau regularmente. A detecção precoce é essencial, pois os
sintomas costumam surgir apenas em estágios avançados da doença. A conscientização e a educação em saúde são
fundamentais para a prevenção, detecção e tratamento adequado.
Palavras-chave: Papilomavírus humano; HPV; Neoplasia intraepitelial cervical
NANO MATERIALS AS A MECHANISM FOR ACHIEVING CONTEXTUALISM IN ARCHITECTURE
Authors: K. Aljashaami Saif , Ali Mohammed Mariam
Published: August 2024

Contextuality is one of the concepts that emerged in the post-modern era and became associated with it as a design strategy. Its purpose is to generate context as a relationship between elements drawn from memory and stored (heritage). Context has both physical and intellectual dimensions in architecture, serving as the language of intellectual and material dialogue between the building and its surroundings. Among its principles are harmony and suitability with the environment, whether through the general form, the materials used in construction and decoration, or through the underlying architectural concept and its alignment with the region's customs and traditions. The absence of context leads to an architectural identity crisis and consequently results in randomness. This is why the research problem revolves around the lack of conceptual clarity regarding the possibility of achieving context in local architecture through the use of nanomaterials to create contemporary architecture. The research aims to elucidate the knowledge about nanomaterials and their potential in achieving contextualism through two direct (as a primary material) and indirect (as a secondary material enabling traditional materials) approaches. Additionally, it examines the environmental context brought about by nanomaterials (harmony with the environment). This is based on the assumption that nanomaterials can be used to enable traditional materials to achieve architectural context for the city. The research employs an analytical and deductive methodology to elucidate knowledge about nanomaterials and their manifestations in architectural production. It derives their influential role in shaping the architectural output by interpreting a set of their properties and characteristics and analyzing a group of buildings where nanomaterials were used. The research concludes that nanomaterials have a direct impact on the final appearance in terms of color, texture, and, hence, the architect must thoroughly study the materials and select the most suitable ones for the region to achieve contextualism.
RESEARCH PROGRESS OF 4D PRINTING TECHNOLOGY
Authors: Hassib Md. Abdul , Islam Md. Rakibul , Karim Md. Rejaul , Hasan Md. Sharjid , Hossain Khan Rajib
Published: August 2024

4D printing technology represents a major advance in additive manufacturing, in which materials can dynamically change shape or properties over time in response to external stimuli. Recent years have seen phenomenal advances in the field of 4D printing technology, which has revolutionized production and design. This review provides a concise overview of the research progress in 4D printing technology, focusing on its principles, applications, and challenges. Researchers have looked into a variety of materials, such as composites and smart polymers that may change programmably in response to light, humidity, or temperature. Applications for 4D printing are found in a wide range of industries, from aerospace parts to biomedical equipment. The creation of self-assembling and adaptable structures has enormous potential for the development of materials that are useful and responsive. Significant developments in the creation of cutting-edge 4D printing methods, like multi-material printing and exact control over shape-changing processes, are highlighted in this review. Challenges, material constraints, and scalability problems are also addressed, with a focus on continuous efforts to overcome them. The revolutionary effect of 4D printing on manufacturing, design, and many other industries is becoming more and more evident as it develops, opening up previously unimaginable opportunities and creative solutions. Finally, challenges and future directions in the field are discussed, aiming to inspire further research and innovation in the dynamic field of 4D printing technology.
Certain applications of q-sigmoid function to neighborhood of analytic functions
Authors: Uzoamaka Nwugo EZEAFULUKWE  , Uzoamaka Azuka EZEAFULUKWE
Published: August 2024

In the present investigation a q-sigmoid function will be introduced to improve some earlier results in geometric function theory. In particular modified q-sigmoid function q-Jack lemma will be applied to certain well defined neighborhood of analytic functions.
Parsonage-Turner Syndrome: An update
Authors: Amália Cinthia Meneses do Rêgo  , Irami Araújo-Filho
Published: August 2024

Parsonage-Turner Syndrome (PTS), known as Neuralgic Amyotrophy or Brachial Plexus Neuritis, is a rare neurological disorder characterized by sudden onset shoulder pain followed by muscle weakness and atrophy. Despite advancements in medical research, the absence of standardized diagnostic and treatment protocols poses significant challenges. This review explores the multifaceted aspects of PTS, including its genetic predispositions, diagnostic advancements, treatment efficacy, and the long-term impacts on patients' quality of life. The heterogeneity of PTS presentations, the lack of specific biomarkers, and the unclear etiology contribute to the complexities in managing this condition. While current treatments vary from conservative to aggressive interventions, their efficacy remains inconsistent due to the syndrome's unpredictable prognosis. The disease's social and psychological impacts necessitate a comprehensive, multidisciplinary approach to patient care. This review underscores the need for further research to elucidate PTS's genetic and immunological underpinnings, develop more accurate diagnostic tools, and establish evidence-based treatment guidelines.
Strategic approaches to enhance the adoption of GLP-1 analogs for diabetes and obesity treatment in India
Authors: Shweta Arora  , Balakrishna Grandhi  , Shital Vakhariya
Published: August 2024

The introduction of GLP-1 analogs in the Indian market holds great potential for diabetes and obesity management, yet their widespread adoption is hindered by several challenges. These include limited long-term data on cardiovascular and renal safety, high costs, lack of outpatient insurance coverage for major drugs, side effects, drug availability issues, and healthcare professionals' (HCPs) reluctance to prescribe them. In a country where many patients pay out-of-pocket and financial planning for healthcare is inadequate, these barriers are further amplified. This study, involving a survey of 250 patients, explores the multifaceted landscape of GLP-1 analogs' acceptance in India. It examines dimensions such as financing schemes, market access strategies, internet trading, and the impact of biosimilars on pricing. By addressing gaps in discussions around discounts, rebates, profits, and price transparency, the research aims to identify key factors that could facilitate the early adoption of GLP-1 analogs in the Indian market. The study advocates for a comprehensive strategy encompassing insurance coverage, patient-centric programs, effective branding, improved drug availability, increased public awareness, and the dissemination of long-term cardiovascular and renal safety data to HCPs. This holistic approach aims to enhance the accessibility of anti-diabetic and anti-obesity products in India, ultimately benefiting a large segment of the population struggling with these conditions. By fostering a deeper understanding and acceptance of GLP-1 among HCPs and patients, the study seeks to pave the way for the successful integration of these innovative therapies into the Indian healthcare system.
Systematic review on Ocrevus for treatment of multiple sclerosis
Authors: S. M. Syed Abdul Subuhan  , W.Helen
Published: August 2024

Adults with relapsing forms of multiple sclerosis (RMS) or primary progressive multiple sclerosis (PPMS) are eligible to receive therapy with ocrelizumab (Ocrevus®), an injectable humanized anti-CD20 monoclonal antibody. In pivotal trials (against interferon β-1a) and supportive single-arm studies in certain subpopulations, ocrelizumab's efficacy in lowering relapse rates and disease activity in RMS patients was established. Comparing ocrelizumab to placebo, measures of clinical and MRI progression were less in PPMS patients. Over 7.5 study years of therapy, clinical benefits were sustained. Overall, ocrelizumab was well accepted, and continued treatment hasn't shown any new safety concerns. A large body of real-world (although brief) evidence about ocrelizumab is in line with data from clinical studies. Clinical tests. The brief, half-yearly injections of ocrelizumab are convenient. As with PPMS patients (for whom there are presently no alternative authorized DMTs), ocrelizumab remains a helpful medication for postponing the course of the disease. It is also a typically well-tolerated, very effective disease-modifying drug (DMT) for RMS.
Isolation of Cellulolytic Bacteria from the Soil Surrounding a Final Landfill Site
Authors: Anggriani Latusi , Larasari Fily , Alvionita Dewinta Nur
Published: August 2024

Cellulolytic bacteria are capable of producing cellulase enzymes, enabling them to break down cellulose into simpler compounds using cellulose as a growth substrate. These bacteria are commonly found in various environments containing cellulose, such as landfill sites where abundant organic materials are present. This research employed the cup-plate isolation method with the aim of obtaining cellulolytic bacterial isolates from the soil surrounding a final landfill site. Successful isolation of cellulolytic bacteria was achieved from soil samples taken in proximity to the disposal site and cultured using selective CMC media. Two purified isolates were obtained, and their cellulase enzyme activities were examined. Isolate LA2 exhibited higher cellulase enzyme activity than isolate LA1, forming a clear zone index of 0.7778. Further quantitative analysis of isolate LA2 revealed its highest enzyme activity at the fifth minute, measuring 0.098 u/ml with a specific activity of 0.29 u/mg protein. Based on physiological characteristics, Gram staining, and spore staining, isolate bacteria LA2 were identified as Pseudomonas sp.
PEREMPUAN DENGAN DISABILITAS DALAM MENGAKSES PELAYANAN KESEHATAN
Authors: Butarbutar Dina Elisabet
Published: August 2024

This study examines the barriers, challenges, and special needs of women with disabilities in accessing health services in Jambi. Based on in-depth interviews and observations, it was found that limited physical accessibility, limited information and communication, as well as stigma and discrimination were the main obstacles. Women with disabilities often do not receive adequate care because existing health services are not tailored to their specific conditions. These findings point to the need for improved disability-friendly infrastructure, training for health workers, and the development of more inclusive health programs. Involving women with disabilities in the health care planning and evaluation process is also important to ensure their needs are met. Public awareness and education about disability need to be increased to reduce stigma and discrimination, thereby creating a more inclusive and supportive environment for women with disabilities.
Praktik Pendidikan Inklusif untuk Anak Berkebutuhan Khusus di Sekolah Dasar
Authors: Atika Atika
Published: August 2024

This study aims to examine the practice of inclusive education for children with special needs in elementary schools. The study identified several key challenges, including a lack of curriculum flexibility, teacher readiness and competence, support from parents and the community, and limited infrastructure and resources. Through interviews and observations, it was found that the existing curriculum is often inadequate to accommodate the needs of students with special needs. In addition, many teachers feel less confident in teaching children with special needs due to the lack of training. Parental and community support also plays an important role, but stigma and lack of understanding are still obstacles. Inadequate infrastructure and resources further hinder the implementation of inclusive education. This research emphasizes the importance of adaptive policies, continuous training for teachers, community education, and improving infrastructure and resources to create an inclusive learning environment.
Heritage Conservation in Indonesia: Policy Review
Authors: Lubis Lunariana , Wardiyanto Bintoro , Setijaningrum Erna
Published: August 2024

The Indonesian government has handed over its authority to ministries and local governments in the field of culture in the designation of cultural heritage since 2010. However, protection of cultural heritage remains limited due to unclear policies and planning. This study aims to identify gaps in existing cultural heritage conservation policy and planning and propose a revised policy framework. After reviewing the cultural heritage conservation policy framework in Indonesia, several shortcomings were found that affect the cultural heritage conservation process. These deficiencies include insufficient coverage of heritage’s context, insufficient institutional capacity, a heritage-owner approach to conservation, inadequate incentives, lack of funding sources, and lack of transparency. To address these shortcomings, several new policies are recommended, including revision of the political system, provision of integrated conservation approaches and incentives, diversification of funding sources, and expansion of public participation.
PENGARUH JOB SECURITY TERHADAP PERSEPSI KESELAMATAN PADA PEKERJA KONSTRUKSI LAPANGAN DI INDUSTRI MINYAK DAN GAS
Authors: Bagos Bagos Armansyah , Fitri Nugraheni
Published: August 2024

Proyek konstruksi merupakan kegiatan yang rawan terhadap terjadinya kecelakaan kerja, sehingga diperlukannya manajemen keselamatan kerja untuk mencegah terjadinya kecelakaan kerja. Salah satu faktor yang sangat mempengaruhi persepsi keselamatan kerja adalah job security. Tujuan penelitian ini adalah untuk mengidentifikasi faktor-faktor job security dan persepsi keselamatan serta menganalisis pengaruh hubungan job security terhadap persepsi keselamatan pada pekerja konstruksi lapangan di industri minyak dan gas, khususnya di wilayah kerja Provinsi Riau. Responden adalah pada pekerja konstruksi lapangan dan berjumlah 106 orang. Metode penelitian yang digunakan adalah kualitatif dan kuantitatif. Terdapat responden mengungkapkan bahwa penerapan job security sudah sangat tinggi, namun beberapa dimensi seperti kenaikan gaji yang berkelanjutan masih kurang baik (34,91%) dan responden menyatakan bahwa pemahaman dan implementasi terhadap persepsi keselamatan sudah sangat tinggi. Hasil uji regresi linier menunjukkan job security berpengaruh positif dan signifikan terhadap persepsi keselamatan pada pekerja konstruksi lapangan, dimana job security memberikan kontribusi terhadap persepsi keselamatan sebesar 21,5%. Semakin pekerja tidak terpenuhi job security, maka pekerja akan semakin tidak peduli terhadap persepsi keselamatan yang dapat menyebabkan tidak terciptanya iklim keselamatan yang baik dan menimbulkan kecelakaan kerja
Analisa Perbandingan Efisiensi Konversi Energi antara PV (Photovoltaic) Monocrystalline 50 WP dan Polycrystalline 50 WP Pada Berbagai Intensitas Cahaya
Authors: Maulana Muhammad Yusuf , Pramono Jati Budi , Widihastuti Ida
Published: August 2024

Ada 2 jenis photovoltaic (PV) atau panel surya, yaitu jenis monocrystalline dan jenis polycrystalline. Monocrystalline berbahan dasar silikon murni sedangkan polycrystalline berbahan dasar silikon campuran. Permasalahan dalam panel surya adalah perbedaan efisiensi dan karakteristik dalam konversi energi pada intensitas cahaya. Untuk mengetahui perbedaan efisiensi dan karekteristik tersebut maka dilakukan pengukuran produksi energi pada PV monocrystalline 50W dan polycrystalline 50W. Paper ini membahas tentang analisa perbandingan efisiensi konversi energi dari kedua jenis panel surya tersebut. Metode penelitian yang digunakan dalam penelitian ini adalah metode true experimental research atau pengukuran secara langsung. Pengukuran dilakukan dengan cara memberi beban lampu dan mengukur produksi energi PV monocrystalline 50W dan polycrystalline 50W secara bersamaan dari pukul 07.00 WIB sampai dengan pukul 17.00 WIB. Tujuanya adalah untuk mendapatkan data waktu, sudut matahari, intensitas cahaya yang dikonversi menjadi irradiasi, tegangan, arus, dan daya produksi konversi energi terhadap pengaruh perubahan intensitas cahaya. Hasil dari penelitian ini adalah pada panel surya jenis polycrystalline saat nilai intensitas cahaya tertinggi sebesar 119260 lux tercatat pada pukul 12.00 WIB dengan niliai irradiasi terhitung 989,86 w/m2 menghasilkan nilai output tertinggi yaitu tegangan sebesar 15,3 V dan arusnya sebesar 1,51 A. Pada panel surya jenis monocrystalline, ketika pada pukul 12.00 WIB tercatat nilai intensitas cahaya tertinggi sebesar 119269 lux dengan nilai irradiasi terhitung 989,93w/m2 menghasilkan nilai output tertinggi yaitu tegangan sebesar 17.2 V dan arusnya sebesar 1.62 A. Hasil perhitungan efisiensi berdasarkan data yang didapatkan adalah panel surya jenis monocrystalline mempunyai efisiensi yang lebih besar dibandingkan dengan  polycrystalline, panel surya jenis monocrystalline  menghasilkan  efisiensi sebesar 8,2 % sedangkan panel surya jenis polycrystalline mengasilkan efisiensi sebesar 7,9 %.
Teachers’ Feedback and Professional Growth in Teacher Education: Implications for Feedback Literacy
Authors: Putri Alice Rachmahanani , Mateus Yumarnamto
Published: August 2024

Teachers’ feedback is important as it provides a starting point for improvement. This study explored teachers’ feedback in the contexts of In-Service Teacher Professional Education Program (Pendidikan Profesi guru Dalam Jabatan/PPG-DalJab). The participants were eight teachers joining the program in 2021. The leading question for the inquiry is related to the feedback the teachers used and how the use of different feedback reflected their feedback literacy. The data were collected from the participants in the form of video recordings of participating teachers’ classes, reflective discussions with the mentor, and documents related to their teaching practice. The data were analyzed for their emerging themes related to feedback given by the teachers during their teachings. This process involved, data coding, identification, and classification of the feedback. The findings indicate that the dominant types of feedback used by the teachers were evaluative feedback, interactional feedback, motivational feedback and corrective feedback. Considering the findings, it is important that English teachers should be aware about their feedback in the classroom for more effective teaching. More importantly, the findings also implied the importance of feedback literacy for teacher professional growth.
Profesionalisme Guru Dalam Meningkatkan Iman Dan Takwa Melalui Pembiasaan Keagamaan Pada Anak Usia 5-6 Tahun Di Tk Miftahul Falah
Authors: Resviani Resi , Gandana Gilar , Sianturi Risbon
Published: August 2024

Guru merupakan pendidik yang sangat penting dalam pembelajaran. Suatu pendidikan tidak akan maju dan berjalan tanpa keterlibatan guru. Oleh karena itu, guru sangat diperlukan untuk menunjang pendidikan yang baik. Penelitian ini bertujuan untuk mengetahui profesionalisme guru dalam meningkatkan iman dan takwa melalui pembiasaan keagamaan pada anak usia 5-6 tahun di TK Miftahul Falah. Metode penelitian ini menggunakan metode kualitatif. Subjek penelitian ini adalah guru dan anak usia 5-6 tahun. Dari hasil observasi dan wawancara menunjukkan bahwa untuk meningkatkan keimanan dan ketakwaan anak, guru menerapkan nilai-nilai agama dengan rutin melakukan kebiasaan seperti membaca doa, membaca Alquran, dan praktik sholat. Melalui pembiasaan beragama ini, anak dapat meningkatkan nilai-nilai keagamaan yaitu keimanan dan ketakwaan. Oleh karena itu, penting bagi para pendidik dalam menjalankan perannya sebagai guru untuk menjadi teladan, pembimbing dan pengarah yang baik bagi anak-anaknya serta menjadikan keimanan dan ketakwaan sebagai hal utama yang perlu diterapkan di sekolah.
Kata Kunci: Pendidikan. Agama, profesionalisme
Laser heat treatment of steels and alloys before diffusion welding
Authors: Khomich Yu. V. ,   Institute of Electrophysics and Electric Power Engineering of the Russian Academy of Sciences, Yamshchikov V. A. ,   Institute of Electrophysics and Electric Power Engineering of the Russian Academy of Sciences
Published: August 2024

The article describes the results of experimental studies on diffusion welding under conditions of hot isostatic pressing with preliminary heat treatment of the surface of workpieces made of a number of steels and alloys by nanosecond pulses of laser ultraviolet radiation. Estimates of the characteristics of laser radiation and the parameters of the modified surface layer due to its melting by a laser pulse are given. It is shown, that the processing of samples from a heat-resistant nickel-based alloy CrNi55MoWZr by a scanning beam of nanosecond laser pulses with a wavelength of 355 nm, a duration of 10 ns and an energy density of 2 J/cm2, following at a frequency of 100 Hz, improved the mechanical properties of the weld. The ultimate strength increased by 10 %, and the elongation increased by 20 %. In addition, the use of a laser made it possible to reduce the temperature of the diffusion welding process by 160 °C while maintaining the mechanical properties of the welded joint. The most probable reason for the improvement of the properties of the welded joint was the appearance of low-temperature super-plasticity caused by the formation of a fine-grained surface structure because of preliminary laser processing of workpieces.
Investigation of the high-temperature background of internal friction in a nitrided heat-resistant nickel-based alloy
Authors: Frolov D. O. ,   Tula State University, Levin D. M. , Manokhin S. S. , Kolobov Y. R. , Ovsepyan S. V. ,   Tula State University,   Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences,   Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences,   Lomonosov Moscow State University,   All-Russian Research Institute of Aviation Materials of the National Research Center “Kurchatov Institute”
Published: August 2024

A study of the parameters of the high-temperature background of internal friction of a dispersed-hardened polycrystalline CrNi29Co28WMoTi alloy has been carried out. It is established that the transition of the investigated alloy from an elastic to a viscoelastic state occurs when the temperature limit Tcr = 791 K is reached in at least two stages. The first stage determines the migration of point defects of the crystal structure along the grain boundaries at low deformation in the low-temperature region, which corresponds to the diffusion activation energy of 0,51 eV. The second stage determines the separation and movement of dislocations from the impurity atoms, as well as the appearance of grain boundary sliding in the high-temperature region. This requires an activation energy of 0,86 eV. The relative decrease in the shear modulus in the temperature range 300 – 890 K was ≈ 0,15. To determine the temperature boundary of the Tcr, a formula is proposed that allows calculating the temperature of the Tcr based on data on the activation parameters of the high-temperature background of internal friction. In addition, a general thermodynamic condition for the transition of a material from an elastic to a viscoelastic state corresponding to high-temperature deformation mechanisms is formulated. It is shown that the temperature boundary that determines the beginning of the transition of a material from an elastic to a viscoelastic state can be used to diagnose the heat-resistant properties of nitrided alloys as an additional criterion.
Structure and mechanical properties of Ti – (36 – 40) Zr – 9 Ta (at.%) alloys for medical purposes
Authors: Volchikhina M. A. ,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, Konushkin S. V. , Mikhlik S. A. , Sergienko K. V. , Kaplan M. A. , Gorbenko A. D. , Sevostyanova T. M. , Kolmakov A. G. , Sevostyanov M. A. ,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences,   GBUZ MO MONIKI named after M. F. Vladimirsky,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences,   Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences
Published: August 2024

In this work, the following are investigated: structure, phase composition and mechanical properties under static tension of titanium alloys Ti – (36 – 40) Zr – 9 Ta (at. %) for medical use after hot rolling and quenching. After rolling, the alloys consist of α′- and β-phases. The results of the research showed that the hardening of alloys leads to the almost complete dissolution of the β-phase and the release of α′- and α″-phases. Investigations of mechanical properties of alloys Ti –(36 – 40) Zr – 9 Ta (at.%) showed that in terms of tensile strength, the studied alloys Ti – 36 Zr – 9 Ta, Ti – 38 Zr – 9 Ta, Ti – 40 Zr – 9 Ta are similar to the VT6 alloy widely used for implants (σ = 835 – 1100 MPa), and in terms of plasticity (δ = 15 – 21 %) and low value Young’s modulus (E = 53 – 73 GPa) significantly exceeds it.
Promising nonwoven materials based on heat-resistant fibers for thermal protection
Authors: Kraev I. D. ,   Emanuel Institute of Biochemical Physics of RAS, Istyagin S. Е. , Sklyarevskya N. M. , Surnin Е. G. , Bibikov S. B. , Sevostianov M. A. ,   Ulyanovsk science-technology center VIAM - National Research Centre “Kurchatov Institute”,   All-Russian Phytopathology Research Institute,   Scientific and Production Company “Aviks” Ltd.,   Emanuel Institute of Biochemical Physics of RAS,   Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences
Published: August 2024

The work is aimed at conducting research on the physical, mechanical, and thermal properties of new nonwoven materials based on heat-resistant fibers. An analysis of existing nonwoven materials of various fibrous compositions, as well as effective water-repellent compositions, was carried out. A technique has been developed for the production of hydrophobized nonwoven materials using solutions of fluorine-containing latex. The main technical characteristics of the developed material were studied and an experimental batch was manufactured.
Asociación de la satisfacción de los resultados del tratamiento de ortodoncia con la percepción de la atención, malestar y dolor durante el tratamiento de ortodoncia
Authors: Munguia-Ibarra Aranza , Gutiérrez-Rojo Jaime Fabián
Published: August 2024

El objetivo de este trabajo fue evaluar la satisfacción de los pacientes durante el tratamiento de ortodoncia en términos de percepción de atención, molestia y dolor. La investigación fue de tipo descriptiva, transversal y observacional. A 107 pacientes, se les realizó el cuestionario de satisfacción de los resultados de ortodoncia, la calidad de atención y la percepción del dolor y molestia durante el tratamiento de ortodoncia. Los resultados fueron separados en tres grupos según el nivel de satisfacción al tratamiento de ortodoncia: muy satisfechos, más o menos y para nada satisfechos. Se realizó estadística descriptiva y la prueba de ANOVA en el programa Stat Calc. El promedio de finalizado el cuestionario fue de 4.9 años. El 45% estaba más o menos satisfechocon el tratamiento. Con la prueba de ANOVA se encontraron diferencias estadísticas significativas entre los grupos en los cambios realizados por el tratamiento, en la información recibida durante el tratamiento y en las preguntas de atención al cliente. Las principales diferencias en la satisfacción del tratamiento de ortodoncia tienen que ver con la atención y comunicación entre el paciente y el ortodoncista. Los pacientes del grupo no satisfecho con el tratamiento refirieron mayores molestias y dolor con el uso de dispositivos de anclaje.