bluuebunny/crossref_metadata_2025 huggingface dataset:
Contexto de cadena cítricos
Authors: Vergara Peña Dais Johanna
Published: March 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena de cítricos enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
The Effect of Implementation of Guideline Order Bundles Into a General Admission Order Set on Clinical Practice Guideline Adoption: Quasi-Experimental Study (Preprint)
Authors: Mrosak Justine , Kandaswamy Swaminathan , Stokes Claire , Roth David , Gorbatkin Jenna , Dave Ishaan , Gillespie Scott , Orenstein Evan
Published: March 2023

BACKGROUND

Clinical practice guidelines (CPGs) and associated order sets can help standardize patient care and lead to higher-value patient care. However, difficult access and poor usability of these order sets can result in lower use rates and reduce the CPGs’ impact on clinical outcomes. At our institution, we identified multiple CPGs for general pediatrics admissions where the appropriate order set was used in <50% of eligible encounters, leading to decreased adoption of CPG recommendations.

OBJECTIVE

We aimed to determine how integrating disease-specific order groups into a common general admission order set influences adoption of CPG-specific order bundles for patients meeting CPG inclusion criteria admitted to the general pediatrics service.

METHODS

We integrated order bundles for asthma, heavy menstrual bleeding, musculoskeletal infection, migraine, and pneumonia into a common general pediatrics order set. We compared pre- and postimplementation order bundle use rates for eligible encounters at both an intervention and nonintervention site for integrated CPGs. We also assessed order bundle adoption for nonintegrated CPGs, including bronchiolitis, acute gastroenteritis, and croup. In a post hoc analysis of encounters without order bundle use, we compared the pre- and postintervention frequency of diagnostic uncertainty at the time of admission.

RESULTS

CPG order bundle use rates for incorporated CPGs increased by +9.8% (from 629/856, 73.5% to 405/486, 83.3%) at the intervention site and by +5.1% (896/1351, 66.3% to 509/713, 71.4%) at the nonintervention site. Order bundle adoption for nonintegrated CPGs decreased from 84% (536/638) to 68.5% (148/216), driven primarily by decreases in bronchiolitis order bundle adoption in the setting of the COVID-19 pandemic. Diagnostic uncertainty was more common in admissions without CPG order bundle use after implementation (28/227, 12.3% vs 19/81, 23.4%).

CONCLUSIONS

The integration of CPG-specific order bundles into a general admission order set improved overall CPG adoption. However, integrating only some CPGs may reduce adoption of order bundles for excluded CPGs. Diagnostic uncertainty at the time of admission is likely an underrecognized barrier to guideline adherence that is not addressed by an integrated admission order set.
Early Triage of Critically Ill Adult Patients With Mushroom Poisoning: Machine Learning Approach (Preprint)
Authors: Liu Yuxuan , Lyu Xiaoguang , Yang Bo , Fang Zhixiang , Hu Dejun , Shi Lei , Wu Bisheng , Tian Yong , Zhang Enli , Yang YuanChao
Published: March 2023

BACKGROUND

Early triage of patients with mushroom poisoning is essential for administering precise treatment and reducing mortality. To our knowledge, there has been no established method to triage patients with mushroom poisoning based on clinical data.

OBJECTIVE

The purpose of this work was to construct a triage system to identify patients with mushroom poisoning based on clinical indicators using several machine learning approaches and to assess the prediction accuracy of these strategies.

METHODS

In all, 567 patients were collected from 5 primary care hospitals and facilities in Enshi, Hubei Province, China, and divided into 2 groups; 322 patients from 2 hospitals were used as the training cohort, and 245 patients from 3 hospitals were used as the test cohort. Four machine learning algorithms were used to construct the triage model for patients with mushroom poisoning. Performance was assessed using the area under the receiver operating characteristic curve (AUC), decision curve, sensitivity, specificity, and other representative statistics. Feature contributions were evaluated using Shapley additive explanations.

RESULTS

Among several machine learning algorithms, extreme gradient boosting (XGBoost) showed the best discriminative ability in 5-fold cross-validation (AUC=0.83, 95% CI 0.77-0.90) and the test set (AUC=0.90, 95% CI 0.83-0.96). In the test set, the XGBoost model had a sensitivity of 0.93 (95% CI 0.81-0.99) and a specificity of 0.79 (95% CI 0.73-0.85), whereas the physicians’ assessment had a sensitivity of 0.86 (95% CI 0.72-0.95) and a specificity of 0.66 (95% CI 0.59-0.73).

CONCLUSIONS

The 14-factor XGBoost model for the early triage of mushroom poisoning can rapidly and accurately identify critically ill patients and will possibly serve as an important basis for the selection of treatment options and referral of patients, potentially reducing patient mortality and improving clinical outcomes.
Epidemiological Features of Uterine Fibroid-associated Imaging Changes in Chinese Women of Reproductive Age: Real-World Study (Preprint)
Authors: Zhang Lijun , Gong Ruoyan , Huang Yanyan , Xu Fan , Xu Wei , Pu Yang , Chen Ke , Zhou Bingqian , Su Xueyao , Zhang Jiayuan , Shi Qiuling
Published: March 2023

BACKGROUND

Uterine fibroids (UF), common benign tumors in women of reproductive age, confer substantial costs. The epidemiological characteristics of UF are unclear in China and Asia.

OBJECTIVE

This study investigated UF-associated imaging changes, and their prevalence, incidence, and risks in the Chinese population.

METHODS

This population-based retrospective analysis of multiyear (2017–2020) health examination data (n=33,915 female participants; age ≥15 years) from Nanchong, China included two expert consultation rounds to identify entries of UF-associated imaging changes and calculate prevalence and incidence of UF-associated imaging changes. Logistic regression estimated the association (odds ratio [OR], 95% confidence interval [CI]) of body mass index, high blood pressure, blood lipid profile, and fasting blood glucose level with UF-associated imaging changes. Age-stratified (≤40 and >40 years) risks were ascertained.

RESULTS

Besides “considering UF”, 17 entries of UF-associated imaging changes screened by the expert consultation were included, involving a total of 46,864 records (n=33,915), and crude prevalence=25.18%; crude incidence density/1000-woman-years=63.28. Incidence and prevalence increased with age during reproductive age (15–49 years) and decreased thereafter. The greatest burden was in 40–54 years women, the prevalence is 38.60%–45.38% and the incidence is 14.73%–17.96%. In the incident younger population (age ≤40 years), risk factors (OR [95% CI]) for UF-associated imaging changes were overweight, high blood pressure (1.48 [1.03–2.14] and 2.16 [1.10–4.24], respectively); in the >40 group, no association was observed.

CONCLUSIONS

UF incidence and prevalence in Asians were higher than previously reported, showed age-related increase in reproductive age, and UF incidence increased with overweight, high blood pressure in ≤40-year-old participants. Variation in UF burden and risk factors was noted in different age range, and risk factors identified in the younger women population make it possible to be early preventive measures for women with a higher risk of UF.
Predictive Modelling and Decision Support in Cardiac Surgery: Requirements Analysis with Cardiac Surgeons and Anesthetists (Preprint)
Authors: Lapp Linda , Bouamrane Matt-Mouley , Roper Marc , Kavanagh Kimberley , Schraag Stefan
Published: March 2023

BACKGROUND

The use of predictive models and decision support systems can potentially make a substantial difference in clinical management and patient care in cardiac surgery. However, in order to develop decision support systems that are fit for purpose, working with clinical domain experts and stakeholders from the start is essential to gather key requirements early on in the system design process, prototyping, testing, and evaluation.

OBJECTIVE

This study aimed to capture the current challenges in cardiac surgery, clinical processes to avoid these challenges, and cardiac surgeons’ and anesthetists’ priorities when developing new prediction models and decision support tools in cardiac surgery.

METHODS

In total, n=12 in-depth semi-structured interviews were conducted across 3 Scottish cardiac centers with cardiac surgeons and cardiac anesthetists. The interview transcripts were analyzed, following a thematic analysis framework and using three a priori themes: “challenges in cardiac surgery”, “current processes to avoid adverse outcomes in cardiac surgery”, and “clinicians’ priorities for new clinical risk prediction models”.

RESULTS

A thematic analysis identified challenges regarding adverse postoperative outcomes connected to the changing cardiac patient population and surgical procedures, challenges in communication between health professionals and patients, and data collection. It was found that preoperative assessment clinics play the most important role when reducing the risk of patients developing adverse postoperative outcomes. Risk prediction tools were largely not used to avoid adverse outcomes, but rather for auditing and documentation purposes.

CONCLUSIONS

The findings of this study suggest that there is a need to increase research efforts on more personalized risk prediction tools and expand the remit of predictions to postoperative complications rather than the more traditional focus on mortality. While there are numerous prediction models in cardiac surgery, the involvement of potential users of such models in the development process is rare. Hence, this study provides a contribution by presenting the cardiac surgeons’ and anesthetists’ priorities for a clinical prediction model.
Online Mental Health Forums and Rural Resilience: Mixed Methods Study and Logic Model (Preprint)
Authors: Steiner Artur , Farmer Jane , Kamstra Peter , Carlisle Karen , McCosker Anthony , Kilpatrick Sue
Published: March 2023

BACKGROUND

Rural mental health is a growing area of concern internationally, and online mental health forums offer a potential response to addressing service gaps in rural communities.

OBJECTIVE

The objective of this study was to explore and identify pathways by which online peer support mental health forums help to build resilience for rural residents experiencing mental ill-health by contributing to overcoming their specific contextual challenges.

METHODS

We developed a Theoretical Resilience Framework and applied it to 3000 qualitative posts from 3 Australian online mental health forums and to data from 30 interviews with rural forum users.

RESULTS

Drawing on the findings and an abductive approach, a logic model was developed to illustrate links between the resilience resources built and enabling features of forums that make them spaces that facilitate resilience.

CONCLUSIONS

The study demonstrated that online forums make valuable contributions to social well-being and access to a range of timely support services for rural people experiencing mental ill-health, and, while doing so, involve users in the processes of resilience building. The study provides a new way for practitioners to frame the work of and value produced by forums. It gives a logic model that can be used in evaluation and audit as it facilitates a causal framing of how forums, as an intervention, link with resilience outcomes. Ultimately, the study contributes to developing new knowledge about how rural resilience building can be conceptualized and measured while showing how forums are part of contemporary health service provision in rural places.
From the Archive to the Computer: Michel Foucault and the Digital Humanities
Authors: Schmidgen Henning , Dotzler Bernhard , Stein Benno
Published: March 2023

Michel Foucault famously introduced the method of “discourse analysis” in the humanities, especially in historiography. In his Archaeology of Knowledge, originally published in 1969, in particular, Foucault argues for making the history of knowledge the object of discourse analyses. In the context of the current surge of interest in discourse analysis in the field of computer science, however, there are hardly any references to Foucault, partly because he never defined a methodological process that could be operationalized. Nonetheless we argue for re-reading the Archaeology of Knowledge in the context of computer science and the digital humanities. As a matter of fact, there are considerable affinities between Foucault’s search for the regularities of discourse and current projects dealing with the digitization of texts, their indexing, distributional features, stylometry, etc. We show that these projects were already quite prominent in Foucault’s day, to the point that historian Emmanuel Le Roy Ladurie could assert, in 1968, that “the future historian will be a programmer.” A year later, Foucault’s Archaeology of Knowledge actively responded and constructively took up the challenge – which, given the recent advances in machine learning and computational linguistics, strikes us as a crucial move today.
A Survey on Strategies and Identity Construction of Coaches in the Voice of China
Authors: Shi Yifan , Liu Zhencong
Published: March 2023

In the past decade, talent shows have gone viral in China. In talent shows, the interaction between the coaches and the contestants is a major attraction for audiences. The coach’s speaking style and pragmatic skills reflect their strategies for recruiting contestants and have influences on identity construction. Based on the Politeness Principle (PP), this study analyzes the utterances of coaches in the recruitment part of The Voice of China season 10. With the help of qualitative analysis software NVivo, researchers try to code the utterances to which PP is applied. Based on the results of the research, this study put forward four recruitment strategies, including Complimentary Strategy, Beneficial Strategy, Emotion Strategy and Modesty Strategy. Moreover, four identities can be constructed based on these strategies, including Amiable Identity, Rational Identity, Perceptual Identity and Modest Identity. This study provides insights into the identity construction of members within an organization from a discourse analysis perspective, especially in the context of talent recruitment and trainee management.
An Analysis on the Ternary Cubic Diophantine Equation
Authors: Janaki G.
Published: March 2023

Abstract: In this article, we concentrate on identifying all the non-zero, infinitely many integral solutions to the ternary cubic equation
Korean Buddhist Tales utilised Cultural Arts Education for Young Children and the Effect on Young Children’s Empathetic Ability from the Integrated Approach of Problem-Based Learning (PBL)
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Ahn Hyun-Jeoung
Published: March 2023

Objectives This study analysed Korean Buddhist Tales utilised cultural arts education for young children and the effect on young children’s empathetic ability from the integrated approach of problem-based learning (PBL). Methods Fifty Gwangju city based five years-old young children (twenty-five children for both experiment group and controlled group) were selected and the experiment were held for eight weeks (four times a week and thirty-two times in total). Five Korean Buddhist tales were selected to build a teaching-learning method that integrates cultural arts education for young children and PBL, and five stages of experiment were executed; stage 1: facing the problem; stage 2: identifying the topic; stage 3: discovery; stage 4: finding the solution; stage 5: presentation and assessment. The examination on the children’s empathetic ability was used to analyze, using SPSS (ver. 26), the difference among groups based on ANCOVA and MANCOVA. Results To sum, Korean Buddhist Tales utilised cultural arts education for young children and the integrated approach of PBL has positive impact on improvement of children’s empathetic ability. Among the sub-elements, communication empathy and cognitive empathy also showed positive impact on this while the other sub-elements that are social empathy and emotional empathy didn’t show a meaningful difference. Conclusions This proves that Korean Buddhist Tales utilised cultural arts education for young children and the integrated approach of PBL have a positive impact in increasing ‘communication empathy’ and ‘cognitive empathy’.
Citizen science and participatory science communication: an empirically informed discussion connecting research and theory
Authors: Giardullo Paolo , Neresini Federico , Marín-González Esther , Luís Cristina , Magalhães Joana , Arias Rosa
Published: March 2023

Citizen Science is believed to contribute significantly to the democratisation of science, engaging non-scientists in scientific research. Participatory approaches to science communication share the same interest through public participation and public engagement. In the attempt to connect these two debates both theoretically and empirically, we provide an analysis of the communication tools and strategies used by 157 Citizen Science projects across the EU, UK, and Switzerland. Our analysis reports that the CS projects surveyed tend to interpret communication as a disseminating activity, rather than as a tool to promote appropriate communication-based encounters with both project participants and other potential target audiences.
Устөрөгчийн атомыг ионы мөргөлтөөр иончлох асуудлыг борын II эрэмбийн дөхөлтөд судалсан нь
Authors: Н Наранцацралт , Р Алтаннар , Л Хэнмэдэх , О Лхагва
Published: March 2023

Тухайн ажилд устөрөгчийн атомыг хурдан ионы мөргөлтөөр иончлох урвалаар сугарсан элсктроны шилжүүлсэн импульст перпепдикуляр хавтгай дээрхи бүрэн дифференциал огтлолын Борын I, 2 —р эрэмбийн ойролцоололд  бодсон онолын өөрсдийн тооцоог онолын судлагааны бусад үр дүнтэй жишив. Борын 2-р эрэмбийн ойролцоолол Glauber ба CDW-RIS аргаар бодсонтой ойролцоо үр дүнд хүргэдгий харуулж байна. Шилжүүлсэн импульст перпепликуляр хавтгай дээр (ф=90) cyrapcaн электроны БДО-ыг тооцоолсон онолын тооцоо Устөрөгч болон Гелийн атомыг иончлох хоёр тохиолдолд төсөөтэй үр дүнд хүрч байгаа нь Гелийн атомын хувьд ажиглаглсан онол туршлагын зөрүү атомын электронуудын хоорондох корреляцаас хамаараагүй болохыг харуулсан.
Negatively Charged Pion Multiplicity Analysis in Hadron-Hadron and Hadron-Nucleus Collisions at Momenta of 1-400 GeV/c
Authors: B Ganhuyag
Published: March 2023

Data on the mean multiplicity of negative pion produced in minimum bias proton-proton, proton-neutron and proton-nucleus interactions as well as central nucleus-nucleus interactions at momenta of I .4-400 GeV/c per nucleon have been compared within the framework of a modified I-RITIOF model [1]. [2].The results for neutron-neutron and nucleon-nucleon interactions were then constructed. The dependence of the mean pion multiplicity in proton-nucleus and central nuclear collisions are studied as a function of the collision energy and the nucleus mass number. The model shows good agreement for pi -mesons, as shown in several comparisons in refs
Вакуумные Технологии Получения Материалов, Содержащих Углеродные Наночастицы Спектральное
Authors: Э.М Шпилевский , П Тувшинтур , Г Шилагарди , С.А Филатов
Published: March 2023

Применяя вакуумные технологии получены содержащие углеродные наночастицы материалы: фуллеренсодержащая чернь, порошок фуллерита, пленки фуллерита и фуллерида,углеродные нанотрубки, пленки композиционных материалов на основе углеродных наночастиц и металлов.
Тамсагийн сав газрын гүний тогтоц
Authors: Б Даариймаа , Ц Баатарчулуун
Published: March 2023

Энэ судалгааны ажлаар Тамсагийн сав газрыг бүрдүүлэгч зарим хотгоруудын орон зайн байршил ба ерөнхий дүр төрхийг соронзон ба хүндийн хүчний судалгааны үр дүнг ашиглан тодорхойлов. Мөн зарим хотгоруудыг дүүргэгч мезо-кайнозойн насны тунамал хурдсын зузааныг хүндийн хүчний үлдэгдэл Буге гажлын урвуу бодолтоор үнэлж өмнө хийгдсэн геологи геофизикийн судалгааны үр дүнтэй харьцуулан судлав.
Жигд бус голомттой, цагираган өндөр температурын хийн хөргөлттэй реакторын нейтроник анализ
Authors: M Т.Жамъянсүрэн , С.Одмаа
Published: March 2023

Реакторыг амжилттай унтраасны дараа голомтод хуримтлагдсан хуваагдлын бүтээгдэхүүнүүдийн задралаас үүсэх дулааныг идэвхгүйгээр зайлуулах чадвартай, цагираган хийцтэй, төвдөө нэг ойлгогчин блоктой, призмэн блокуудаас бүрдэх 100МВт дулааны чадалтай, 1123 K температурт ажиллах ӨТХР-ийн голомтын дизайныг хийж түлш, шатдаг хорлолт материал жигд байх үеийн нейтроник үзүүлэлтүүдийг өмнөх ажилд гарган авсан. Энэхүү ажилд голомтын дизайныг илүү оновчтойболгохын тулд түлш, шатдаг хорлолт материалын агууламжыг жигд бус болгон өөрчилж реактивитийн хугацааны өөрчлөлтийг бууруулах тооцооллуудыг гүйцэтгэн, реактор ажиллах нийт хугацааны туршид үүссэн бага хэмжээний реактивитийг удирдлагын савааг голомтод оруулах замаар хангалттай хэмжээнд бууруулж, чадлын пикийн факторын түгэлтийг жигд болгосон. Түүнчлэн реактивитийн температурын болон чадлын коэффициентыг үнэлэв.
Hydrogen atom ionization in femtosecond laser field: Numerical solution of the TDSE using CWFDVR method
Authors: Ch.Aldarmaa  , L.Khenmedekh  , G.Zorigt
Published: March 2023

We present an discrete variable representation for solving the time-dependent Schrodinger equation for an atomic system interacting with an intense laser pulse. Instead of the usual finite difference (FD) method, the radial coordinate is discretized using the discrete variable representation (DVR) constructed from Coulomb wave functions. Our results are in excellent agreement with other accurate theoretical calculations using different methods.
Terminology of geoinformatics and cartography in the digital age
Authors: Koshkarev A.V.
Published: March 2023

Formation of Russian-language terminology in geoinformatics and cartography that started in 1970–1980ies has not yet been completed. Digital transformation generates new words, word combinations and terms. The actual imperfection of terminology is demonstrated by the example of two key definitions in geoinformatics. ‘‘Spatial object’’ refers to two different entities
Increasing trends in a low 5-minute Apgar score among (near) term singletons: a Dutch nationwide cohort study
Authors: Tacke C.E. , Onland Wes , Bakker Petra , Groenendaal Floris , Rosman Ageeth , Broeders Lisa , Been Jasper , Ravelli Anita
Published: March 2023

Objective: To investigate trends in low 5-minute Apgar scores in
(near) term singletons. Design: Nationwide cohort study.
Setting: The Netherlands. Population: A cohort of
1,583,188 singletons liveborn between 35 and 42
weeks of gestation in the period 2010-2019 from the
Dutch Perinatal Registry. Methods: We studied trends using
Cochrane-Armitage trend tests. Risk factors were studied by logistic
regression analysis and Population Attributable Risk (PAR) calculation.
Main outcome measures: Low 5-minute Apgar score (<7 and
<4) as primary outcome. Results: The proportion of
infants with low 5-minute Apgar score <7 and <4
increased significantly between 2010 and 2019 (1.04-1.42%
(p<0.001), 0.17-0.19% (p=0.009), respectively). While
neonatal mortality remained unchanged, NICU admissions and low umbilical
artery pH’s increased significantly. Many perinatal characteristics
showed a significant association with low Apgar scores. The highest
risks were found for nulliparity, epidural analgesia, emergency
caesarean section, instrumental vaginal delivery, prolonged second stage
of labour, male sex and delivery in secondary care. The obstetric
interventions induction of labour, epidural analgesia and planned
caesarean section showed an increasing trend. Instrumental vaginal
delivery and emergency caesarean section were performed less frequently
over time, however within these obstetric intervention subgroups the
highest increase in low Apgar scores was observed. Conclusions In
the Netherlands, the risk of a low 5-minute Apgar score increased
significantly over the last decade, with the highest increase being
observed in the obstetric intervention subgroups of instrumental vaginal
delivery and emergency caesarean section. Neonatal mortality remained
stable over the study period.
Impact of COVID-19 on the Distribution of Pathogenic Bacteria in the Lower Respiratory Tract of the Elderly
Authors: Zhang Shiyan , Shi Jing , Zhuo Ying , Wang Tingqiang
Published: March 2023

Background: To investigate the distribution of bacterial pathogens of
lower respiratory tract infection (LRTI) in hospitalized elderly
patients during the COVID-19 epidemic and to explore the influence of
COVID-19 on the distribution of bacterial pathogens, in order to provide
guidance for clinical diagnosis. Methods: Specimens of sputum from
elderly LRTIs patients at Fuding Hospital of China were collected from
October 2022 to January 2023. Cultures and identification were done, and
RT-PCR was employed to detect SARS-Cov-2 nucleic acid. Results: A total
of 195 isolates were characterized in 163 sputum samples of consecutive
hospitalized elderly patients, of which 11.3% were Gram-positive
bacteria and 88.7% Gram-negative. The top of frequently isolated
pathogens were Klebsiella pneumonia (30.3%), Pseudomonas aeruginosa
(19.0%), Acinetobacter baumannii (12.8%), Stenotrophomonas maltophili,
(7.7%), Escherichia coli (7.2%). According to the results of novel
coronavirus nucleic acid detection, the 163 patients were divided into
COVID-19 group and non-COVID control (CNT) group. The comparison of
bacterial distribution between the groups revealed that Stenotrophomonas
maltophilia was lower in the COVID-19 than in the CNT group, while
Acinetobacter baumannii was higher in the COVID-19 group, and the
difference was statistically significant (P < 0.05).
Conclusion: The major bacteria identified in sputum culture of
hospitalized elderly patients were Klebsiella pneumonia, Pseudomonas
aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia, and
Escherichia coli. Furthermore, the distribution of Stenotrophomonas
maltophilia and Acinetobacter baumannii between the COVID-19 and CNT
groups was found to be significantly different (P< 0.05),
while there were no significant differences in the distribution of other
bacteria.
Nonlinear Control of a Hybrid Pneumo-Hydraulic Mock Circuit of the Cardiovascular System
Authors: Kadıpaşaoğlu Kamuran , Alhajyounis Ahmed , Aydoğan Yiğit , Canbaş Arda , Kulakoğlu Emir , Kurnaz Umut , Soysal Levent , Yiğit Mert , Arısoy Doğan
Published: March 2023

Objective: Hybrid cardiovascular mock circuits (HMC), designed
for dynamic testing of Ventricular Assist Devices (VAD), offer
physiologic accuracy by sequestering model complexity in silico
and ease of construction by reducing number of model elements in
vitro. Despite superior response time and precision, pneumatic
actuation is avoided in HMCs due to nonlinear dynamics and noise. We
tested the hypothesis that a HMC consisting of a variable
elastance-driven numerical circuit coupled to a pneumo-hydraulic
physical circuit can be controlled without linearizing system dynamics.
Methods: Reference left ventricular and aortic pressures
generated in silico were tracked, respectively, in in
vitro preload and afterload reservoirs by controlling non-linear
pneumatic dynamics using the Lyapunov stability criterion. A centrifugal
pump, the speed (i.e. flow) of which was adjusted using PID control, was
interposed between the reservoirs and mimicked the VAD under evaluation.
The flow of a recirculating gear pump was controlled by the backstepping
method to equalize reservoir fluid volumes by rejecting pressure and
flow disturbances. Sensor noise was reduced with discrete-time Kalman
filtering. Results: Our results showed that normal, failing and
assisted cardiovascular physiologies were numerically simulated and
tracked at physical VAD terminals with high accuracy. Reservoir volumes
remained stable at various combinations of heart rate, pressure, and VAD
flow. Conclusion: The HMC described here offers a stable
performance testing platform for VAD prototypes. Significance: This is the first proof that hybrid systems using pneumatic
actuation at hydraulic interfaces can optimally be regulated with
nonlinear controllers to achieve precise reference tracking and robust
disturbance rejection.
Characteristics and Incidence of Patients With Tricuspid Valve Prolapse After Micra Transcatheter Pacing System Implantation
Authors: Kawatani Shunsuke , Okamura Akihiro , Kato Masaru , Tomomori Takuya , Takami Aiko , Mukai-Yatagai Natsuko , Nakamura Kensuke , Ishisugi Takuya , Yamamoto Kazuhiro
Published: March 2023

Background: The characteristics and incidence of patients with
tricuspid valve (TV) prolapse after leadless pacemaker implantation are
unknown. Methods and Results: We retrospectively identified 35
of 85 patients with sufficient echocardiographic TV imaging before and
after Micra transcatheter pacing system (Micra TPS) implantation. The
post-procedure incidence of TV prolapse was 8.6%, and the cause of
prolapse was chordae tendineae rupture. Patients with TV prolapse had
significantly longer procedure times and more deployments than patients
without TV prolapse. Conclusions: TV prolapse after Micra TPS
implantation is not a rare complication and is accompanied by frequent
deployments and prolonged procedure times.
Atypical transient network states of autism spectrum disorder: resting-state fMRI study using co-activation pattern
Authors: Zhang Yunge , Zhou Dongyue , Lin Lin , Stein Abigail , Xu Huashuai , Zhao Wei , Zhou Shuqin , Du Fei , Li Huanjie , Cong Fengyu
Published: March 2023

Static features of the executive control network (ECN), dorsal attention
network (DAN), default mode network (DMN), and salience network (SN)
have displayed dysfunction in people with autism spectrum disorder
(ASD). However, research on the dynamic brain function of these networks
in ASD is rare. In this study, co-activation pattern (CAP) analysis was
performed on the whole cortex to study dynamic dysfunction in ASD using
a large multisite resting-state fMRI dataset (295 ASDs, 446 healthy
controls). Eight transient network states (TNSs) were defined, the dwell
time, persistence, and transitions of each TNS were calculated to
evaluate dynamic brain function. Using hierarchical clustering, the
eight TNSs were divided into three clusters: ‘DMN activating’, ‘SN
activating’, and ‘ECN and DAN activating’. We found ‘ASD-biased’ DMN and
SN TNSs, which showed larger dwell time and longer persistence in ASD
group than healthy control (CON) group. More transition within
‘ASD-biased’ TNSs were found in ASD group. Dwell time of the
‘ASD-biased’ ‘SN activating’ TNS was significantly correlated with
social deficits only in the ASD group. Our results imply the dynamic
dysfunction of ASD does not come from the occurrence of DMN, ECN, or SN,
but comes from the atypical co-activation patterns within them. Our
results also indicate people with ASD have stronger negative
connectivity between DMN and ECN in childhood. This connection dosen’t
change significantly with age in ASD group, but is supposed to increase
with age until adulthood as the growth trajectory in healthy inviduals,
which implies the early overgrowth of ASD children.
Pharmacist Integration into the Hemophilia Treatment Centre: A Canadian Pilot Project to Optimize Treatment and Improve Cost-savings
Authors: Cameron Jameason , Varughese Nisha , Grenier Sylvain , Roux Damien , Klaassen Robert , Wong Alex , Jones Caitlin , Jennings Sarah , Patel Utsav , Sidhu Simmi , Vaillancourt Regis
Published: March 2023

Coagulation factors used in prophylactic treatment of patients with
clotting disorders are associated with significant costs to health care
systems. These products have complex pharmacokinetic profiles subject to
large inter-individual variation making their efficient use challenging.
Prior to this project, pharmacists were not involved as part of the
Hemophilia care teams across Canada. The purpose of this pilot project
was to determine whether employment of a pharmacist with expertise and a
focus on plasma protein and related products including hemophilia
treatments, would be an effective strategy to reduce costs associated
with clotting factor prophylaxis regimens and identify the pharmacist’s
activities associated with this new role. A cost-minimization analysis
was conducted to compare the addition of a pharmacist to the care team
of the Hemophilia Treatment Centre (HTC) at a pediatric hospital serving
500,000 children and youth. The analysis was performed from the
perspective of the formulary manager, Canadian Blood Services, over a
1-year period including 9 months of interventions. The pharmacist
performed 18 therapeutic optimizations on 14 patients with moderate to
severe hemophilia A or B, and 1 von Willebrand patient, aged 3 to 18
years old. As a result of the pharmacist’s intervention, clotting factor
treatment costs extrapolated over one year were reduced by 20.5% for
these patients. This represents a net savings of $225K CAD/year, or
$12.5K CAD/optimization/year. The addition of a pharmacist to the HTC
to manage recombinant and plasma-derived coagulation factors can
optimise the treatment plan and significantly reduce the costs of
managing patients with hemophilia.
Implications of the 7th NFC Award on Health Services in Pakistan
Authors: Bakhtiar Khan Muhammad , Khan Malik Zilakat , Shahid Malik Wasim
Published: March 2023

Fiscal decentralization is aimed to improve Public Services Delivery as the subnational governments get control of additional revenue and expenditures responsibilities and are in a better position to provide basic services to the local people. The 7th NFC Award is considered as a big step toward fiscal federalism wherein the criteria for horizontal and vertical distribution of resources has been changed to accommodate major demands of the federating units. This research paper has been an attempt to identify that to what extent the new fiscal arrangements under the 7th NFC Award has been successful to improve health services delivery in Pakistan. For this study data on various health indicators has been collected for the period 2001 to 2019 divided into two groups i.e., pre 7th NFC period (2001 to 2010) and post 7th NFC Award period (2011 to 2019). To identify the impact of 7th NFC Award on health services delivery in Pakistan various variables were selected including Infant Mortality, Under Five Years’ Mortality, Life Expectancy at Birth and Health Expenditures (%GDP) as dependent or endogenous variables at national level whereas for comparison at provincial level Life expectancy at birth and Under Five Years mortality were used as dependent variables. The variables were tested at the national level as well as the provincial level and interprovincial comparison was also performed. For the analysis purpose different techniques for trend analysis were applied including the Chow breakpoint test, recursive coefficient, Wald-Coefficient Restriction test, Equality of Variance test, trend estimates, Durbin Watson Test and Forecast analysis. Additionally, the Difference-in-Difference approach was also applied to compare other provinces as treatment groups i.e., Sindh, Khyber Pakhtunkhwa and Baluchistan with Punjab as a control group. The results suggest health indicators have responded positively to the additional funds’ transfer and Life expectancy at birth, Infant mortality and Under Five years’ mortality have improved at national level. Life expectancy and under five years’ mortality has generally improved in all provinces except for life expectancy in KP. While comparing the performance of other provinces with Punjab it is found that life expectancy at birth, infant mortality and Under Five years’ mortality have improved in Sindh and Khyber Pakhtunkhwa while Baluchistan did not improve health indicators in comparison to Punjab. However, to realize further benefits of the fiscal decentralization it is suggested that additional fund transfer is not a sufficient factor to bring change and should be complemented by administrative and legislative actions on part of the government. Innovations and the role of the private sector are crucial in improving public services delivery in health sector. Moreover, the capacity of the government machinery and the ability to develop plans and strategies is important to realize the benefits of the fiscal decentralization by the provinces.
Preservation and Dissemination of Indigenous Knowledge in Pashtuns’ Culture: The Role of Hujra as a Learning Hub
Authors: Rehman Seema , Ahmad Ijaz , Hamid Khan Salman
Published: March 2023

In Pashtuns’ culture, Hujra represents a unique facet of communal development and social uplift. It is a platform for the villagers for discussing various issues including but not limited to problems related to their personal and family matters, agricultural and farming, education and politics, and business and trading, with their focus on the immediate solutions, based on the community’s viewpoints, wisdom and inherited knowledge. The present era has misrepresented the role of Hujra as a forum of cultivating miscreants and ill-mannered posterity. Hence, the fact has been kept at the back burner that cultural codes of Pashtunwali, the unwritten/traditional norms termed as indigenous knowledge, have been transferred to the young generations through a communal Hujra. The present study aims at discussing and unveiling the multi-dimensional roles of Hujra. The study was an exploratory research for which qualitative method was used. The primary data was collected through semi-structured interviews and focus group discussions with the local/indigenous people, Maliks (Masharan, elders) and youngsters of the village, Daman Afghani, district Peshawar, Khyber Pakhtunkhwa, Pakistan. The target population of the study was sixteen (16) individuals randomly selected from the population through Convenience Sampling Technique. The finding of this research focused not only on the role of a communal Hujra but also threw light on the status of a personal Hujra in dissemination of indigenous knowledge. Both play fundamental roles in the preservation of the cultural heritage, aims at promoting indigenous knowledge.
Exploring Intellectual Liabilities in Universities – Case Study of a Public Sector University
Authors: Zain Gohar Muhammad , Alam Khan Awais
Published: March 2023

Public universities are going through a tough time in Pakistan and some of the old universities are facing severe financial crisis to the extent that they cannot even pay their employees. This drift took a long time, and it is mainly due to increase in the intellectual liabilities. While intellectual capital is seen as non-physical resources which helps to create value, intellectual liabilities are the intangible rigidities that destroys the value. This paper explores the creation of intellectual liabilities in universities due to different prevailing processes and practices and the ignorance of its implications by the management, using a public sector university as a case study. Actor-Network Theory is utilized to develop the understanding of the phenomenon, to appreciate the complexity of reality and understanding how social effects are generated as a result of associations between different actors in a network A qualitative research approach was adopted, and primary data was collected through semi-structured interviews and thematic analysis have bene utilized for its analysis. Findings suggest that intellectual liabilities have a destructive role in universities. The findings can prove useful to human resource managers, policy decision-makers, as well as government and academic institutions in understanding what intellectual liabilities is and how they can develop gradually if not prevented.
Proactive Obsolescence Management Methods for C5ISR Systems: Insights from Practitioners
Authors: Chellin Matthew , Miller Erika
Published: March 2023

Obsolescence is a significant challenge for the Command, Control, Communications, Computers, Cyber, Intelligence, Surveillance and Reconnaissance (C5ISR) community. Obsolescence can negatively affect a C5ISR system’s cost, schedule, performance, and readiness. This article examines the challenge of obsolescence for C5ISR systems by focusing on the U.S. Army at Aberdeen Proving Ground, Maryland, and their industry partners. Data were gathered by conducting interviews with 20 individuals who had experience with C5ISR systems: 10 government Army civilians and 10 industry partner employees. The objective of this study is to synthesize insights from the experiences of government and industry practitioners that mitigate diminishing manufacturing sources and material shortages (DMSMS) challenges.
The obsolescence mitigation areas described in this article include proactive and reactive obsolescence mitigation, obsolescence mitigation methods, opportunities for alternative components and planned improvements, the importance of DMSMS contracting language, and obsolescence management practices to avoid. This article also offers approaches grounded in practitioner experiences to mitigate obsolescence through a preliminary proactive obsolescence management model, risk mitigation framework, and metrics. The combination of the obsolescence mitigation approaches discussed in this article has the potential to achieve greater system readiness, more availability, better maintainability, and lower costs for C5ISR systems.
Impact of High Trade Costs and Uncertain Time to Trade on Exports from Five Central Asian Countries
Authors: Sharafeyeva Alfinura
Published: March 2023

This paper analyzes how trade costs affect exports from five Central Asian countries. It highlights how improving logistics and procedures and boosting digitalization can streamline regional trade. The paper estimates how the time needed to export goods, the monetary cost of doing so, and uncertain time frames impact exports from Kazakhstan, the Kyrgyz Republic, Tajikistan, Turkmenistan, and Uzbekistan. It finds that the uncertainty and the high monetary costs traders face hold back exports from the five countries, along with remoteness from ports and global markets.
Üniversite Yerleşkesi Çevresinde Trafik Durumunun İncelenmesi ve Alternatif Çözüm Önerileri: İstanbul Üniversitesi Cerrahpaşa Avcılar Kampüsü Örneği
Authors: KARAKAŞ Ahmet Sertaç
Published: March 2023

Büyükşehirlerde artan nüfusu beraberinde barınma, eğitim, ulaşım vs. birçok ihtiyaç parametrelerini doğurmaktadır. Yerleşik düzende olan alanların üniversite ihtiyaçlarını karşılamak için 24 saat aktif yaşamın sürdüğü kampüs alanlarınada ihtiyaç duyulmaktadır. Özellikle kampüs ihtiyacının karşılandığı alanlarda kentsel ulaşım ağı koşullarında da gerekli iyileştirmelerin yapılması ve ilerideki nüfus ve eğitim kapasite koşulları dikkate alınarak senaryoların geliştirilmesi gerekmektedir. Dolayısıyla eğitim alanlarına kolay ulaşaılabilirliğin sağlandığı konforlu ve güvenilir yol ağlarının oluşturulması elzemdir. Geliştirilen modeller ile kentsel ölçekte kampüs ve yerleşim alanlarında yol ağları oluşturularak trafik problemlerine çözüm önerileri getirilmesi, otopark ihtiyaçların karşılanması, trafik akışının sağlanması, yayaların güvenli bir şekil de ulaşım imkanı elde edilmedir. Bu çalışmada İstanbul tarihi yarımada dışında kalan üniversite kampüs alanı ve çevre bağlantı yollarında meydana gelen trafik yoğunluğu dikkate alınarak geliştirilen senaryolarla ileriye yönelik tahminlerde trafik sorunlarının ortadan kaldırılmasına yönelik alternative çözüm önerileri gerçekleştirilmiştir. Çalışmada önceden belirlenen bir ufuk yılına göre gelecekteki potansiyel trafik akışını ölçmek için karmaşık trafik yöntemleri tasarlanmıştır. Sonuç olarak farklı ulaşım planlaması ve araç modellerinin trafiğe olumlu katkı sunacağı düşünülmektedir.
Deprem Mühendisliği Uygulamalarında Kullanılmak Üzere Açık Kaynaklı Bir Yazılım Geliştirilmesi: DARLA (Versiyon 1.0)
Authors: MERT TUĞSAL Ülgen , KÖMEÇ MUTLU Ahu
Published: March 2023

Yeni gelişen teknolojilerle beraber deprem mühendisliğindeki uygulamalarda kullanılmak üzere deprem karakteristik özelliklerinin ve mühendislik şiddet parametrelerinin hızlı ve pratik bir şekilde belirlenebilir olması önem arz etmekte olup, yazılımsal olarak parametrelerin entegrasyonu uygulamalarında artış gözlemlenmektedir. Bu çalışmada, Python yazılım dili kullanılarak, belli bir depreme ait, kuvvetli yer hareketi kayıtları zaman serisi kayıtlarından, maksimum ivme (Peak Ground Acceleration (PGA)), maksimum hız (Peak Ground Velocity (PGV)) ve maksimum yerdeğiştirme (Peak Ground Displacement (PGD)) değerleri hesaplanmış; kayıtlara ait hız-ivme-yerdeğiştirme zaman serileri üretilmiş; tepki spektrumları Türkiye Bina Deprem Yönetmeliği’nde (TBDY-2018) tanımlanmakta olan tasarım spektrumları ile karşılaştırılarak görselleştirilmiştir. Deprem sinyallerinin frekans içerikleri de ayrıca elde edilmiştir (Fourier Amplitude – Frequency grafikleri). Elde edilen çıktılar görselleştirilerek, yorum kolaylığı sağlanması amaçlanmıştır. Çalışma kapsamında geliştirilen açık kaynaklı yazılım (Depremlerin kARakteristik özeLliklerini Ayrıştırma: DARLA v1.0) yardımıyla, deprem meydana geldiği andan itibaren bölge özelinde deprem mühendisliği anlamında yarı-otomatik üretilen bilimsel veriler ışığında hızlı değerlendirme yapılması hedeflenmiştir.
Analysis of Factors Affecting Go-Jek Driver Income during the Covid-19 Pandemic in Denpasar City
Authors: Kurniawan Moh F. , Marhaeni Anak A. I. N.
Published: March 2023

Transportation is an important element and serves as the lifeblood of life and economic, social, and political development, and population mobility. With all the problems regarding transportation and the needs of the community, the online motorcycle taxi was born, one of the companies that provide this service is PT. GO-JEK. However, at the end of 2019, the Coronavirus, or SARS-CoV2, commonly known as Covid-19 spread worldwide. In the Instruction of the Minister of Home Affairs No. 15 of 2021 concerning controlling the spread of Covid-19, the government adopted a policy to implement The Community Activities Restrictions Enforcement (CARE) aimed at recovering the economy of people affected by the Covid-19 pandemic. This research is quantitative in the form of associative. This research is located in Denpasar City. The population in this study are go-jek drivers in Denpasar City With 96 respondents. The analysis technique used in this research is descriptive statistical analysis. The study results show that incentives, working hours, work experience, and Emergency Community Activity Restrictions simultaneously affect the income of go-jek drivers in Denpasar City. Incentive variables, working hours, and work experience partially have a positive and significant effect on the income of go-jek drivers in Denpasar City. The Community Activities Restrictions Enforcement (CARE) partially have a negative effect on the income of go-jek drivers in Denpasar City
Újabb fullánkos hártyásszárnyú (Hymenoptera, Aculeata) fajok Somogyból
Authors: Józan Zsolt
Published: March 2023

In this paper the author publishes new species of Aculeata found in Somogy County in the last decade. The following species have to be deleted from the list published by Józan (2001) because of misidentification: Smicromyrme pusilla (Klug), Smicromyrme punctata (Latr.) (Mutillidae), Chrysura rufiventris (Dhlb.), Hedychridium aheneum (Dhlb.) (Chrysididae), Pemphredon brevipetiolatus Wagner (Sphecidae), Lasioglossum intermedium (Schck.), Lasioglossum limbellum (Mor.), Anthophora aestivalis (Pz.) (Apidae). Psammaecius punctulatus (Lind.) (Sphecidae) is a new species for the fauna of Hungary. So far 1008 species have been recorded from the fauna of Aculeata (except species of Formicidae and Bethyloidea) in Somogy County.