bluuebunny/crossref_metadata_2025 huggingface dataset:
Success and Complication Rates of Transvenous Lead Extraction in a Developing High-Volume Extraction Center: The Zurich Experience
Authors: Hofer Daniel , Kuster Noah , Bebié Michelle C. , Sasse Tom , Steffel Jan , Breitenstein Alexander
Published: March 2023

Introduction: Transvenous lead extractions are increasingly performed for malfunction or infection of cardiac implantable electronic devices, but they harvest a potential for complications and suboptimal success. Apart from multicenter registries and reports from highly experienced single centers, the outcome in individual newly developing high-volume centers starting a lead extraction program is less well established. We aimed to evaluate the clinical and radiological success and complication rate at our center, having started a lead extraction program less than a decade ago. Methods: We retrospectively analyzed patients who underwent transvenous lead extraction at the University Hospital Zurich from 2013 to 2021 regarding success as well as complications and compared our results to previously reported outcome rates. Results: A total of 346 patients underwent 350 transvenous lead extractions from January 2013 to December 2021. Combined radiological success was achieved in 97.7% and clinical success in 96.0% of interventions. Procedure-related major complications occurred in 13 patients (3.7%). Death within 30 days after transvenous lead extractions occurred in 13 patients (3.7%), with a procedure-related mortality of 1.4% (five patients). Summary: Transvenous lead extractions in newly developing high-volume centers can be performed with high clinical and radiological success rates, but procedure-related major complications may affect a relevant number of patients. Compared to large single or multicenter registries of experienced centers, the success rate may be lower and the complication rate higher in centers newly starting with lead extraction, which may have important implications for patient selection, procedural planning, proctoring, and safety measures.
An Overview of Postoperative Intraabdominal Adhesions and Their Role on Female Infertility: A Narrative Review
Authors: Ghobrial Stefan , Ott Johannes , Parry John Preston
Published: March 2023

Postoperative intraabdominal adhesions can occur after more than 90% of gynecologic surgeries. They not only cause chronic pelvic pain and small bowel obstruction, but are also one of the main reasons for infertility. Adhesions are not only a burden for the affected patients, but are also a burden for the healthcare system, since the treatment of adhesion-associated complications costs a considerable amount of money. The gold standard for the diagnosis of adhesions is by laparoscopy, although other methods, such as transvaginal hydro-laparoscopy, are being discussed as better alternatives. Ideally, adhesions are avoided inherently, by operating carefully and by using microsurgical principles. If this is not possible, gel barriers have been shown to be successful in reducing postoperative adhesions.
The Availability, Cost, Limitations, Learning Curve and Future of Robotic Systems in Urology and Prostate Cancer Surgery
Authors: Hughes Thomas , Rai Bhavan , Madaan Sanjeev , Chedgy Edmund , Somani Bhaskar
Published: March 2023

Robot-assisted surgical systems (RASS) have revolutionised the management of many urological conditions over the last two decades with robot-assisted radical prostatectomy (RARP) now being considered by many to be the preferred surgical approach. Intuitive Surgical has dominated the market during this time period with successive iterations of the da Vinci model. The expiration of patents has opened the RASS market and several new contenders have become available or are currently in development. This comprehensive narrative review aims to explore the merits of each robotic system as well as the evidence and barriers to their use. The newly developed RASS have increased the versality of robotic surgical systems to a wider range of settings through advancement in technology. The increased competition may result in an overall reduction in cost, broadening the accessibility of RASS. Learning curves and training remain a barrier to their use, but the situation appears to be improving through dedicated training programmes. Outcomes for RARP have been well investigated and tend to support improved early functional outcomes. Overall, the rapid developments in the field of robot-assisted surgery indicate the beginning of a promising new era to further enhance urological surgery.
Relationships of Whole-Heart Myocardial Mechanics and Cardiac Morphometrics by Transthoracic Echocardiography with Main Prognostic Factors of Heart Failure in Non-Ischemic Dilated Cardiomyopathy
Authors: Mėlinytė-Ankudavičė Karolina , Ereminienė Eglė , Mizarienė Vaida , Šakalytė Gintarė , Plisienė Jurgita , Ankudavičius Vytautas , Dirsienė Rūta , Žaliūnas Remigijus , Jurkevičius Renaldas
Published: March 2023

Background: there are many prognostic factors of heart failure (HF) based on their evaluation from imaging, to laboratory tests. In clinical practice, it is crucial to use widely available, cheap, and easy-to-use prognostic factors, such as left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) functional class, 6 min walk test (6MWT), B-type natriuretic peptide (BNP), etc. We sought to evaluate the relationships between whole-heart myocardial mechanics and cardiac morphometrics with the main commonly used prognostic factors of HF in patients with non-ischemic dilated cardiomyopathy (NIDCM). Methods and results: two-dimensional (2D) echocardiography for myocardial mechanics (global longitudinal, radial, and circumferential strains of the left ventricle; right ventricular longitudinal strain; strain values of reservoir, conduit, and contraction function of both atria) and cardiac morphometric (diameters and volumes of both atria and ventricles) parameters were performed, and the HF main traditional prognostic factors were identified. We assessed 109 patients (68.8% male; 49.7 ± 10.5 years) with newly diagnosed NIDCM. Myocardial mechanics and morphometrics were weakly correlated with the patient’s age, gender, and smoking (R = 0.2, p < 0.05). Stronger relationships were observed with NYHA class, 6MWT, and BNP (the strongest correlations were with LVEF: R = −0.499, R 0.462, R = −0.461, p < 0.001, respectively). There were moderately strong correlations with LVEF and other whole-heart myocardial mechanics or morphometrics. Moreover, LVEF with global regurgitation volume (GRV) and right ventricle free wall longitudinal strain (RVFWLS) were the most usually detected parameters in multivariate analysis to be associated with changes in HF prognostic factors. Conclusions: in NIDCM patients, the main prognostic factors of HF are correlated with whole-heart myocardial mechanics and morphometrics. However, LVEF, GRV, and RVFWLS are the most usually found 2D echocardiographic factors associated with changes in HF prognostic factors.
Machine Learning Model Based on Optimized Radiomics Feature from 18F-FDG-PET/CT and Clinical Characteristics Predicts Prognosis of Multiple Myeloma: A Preliminary Study
Authors: Ni Beiwen , Huang Gan , Huang Honghui , Wang Ting , Han Xiaofeng , Shen Lijing , Chen Yumei , Hou Jian
Published: March 2023

Objects: To evaluate the prognostic value of radiomics features extracted from 18F-FDG-PET/CT images and integrated with clinical characteristics and conventional PET/CT metrics in newly diagnosed multiple myeloma (NDMM) patients. Methods: We retrospectively reviewed baseline clinical information and 18F-FDG-PET/CT imaging data of MM patients with 18F-FDG-PET/CT. Multivariate Cox regression models involving different combinations were constructed, and stepwise regression was performed: (1) radiomics features of PET/CT alone (Rad Model); (2) Using clinical data (including clinical/laboratory parameters and conventional PET/CT metrics) only (Cli Model); (3) Combination radiomics features and clinical data (Cli-Rad Model). Model performance was evaluated by C-index and Net Reclassification Index (NRI). Results: Ninety-eight patients with NDMM who underwent 18F-FDG-PET/CT between 2014 and 2019 were included in this study. Combining radiomics features from PET/CT with clinical data showed higher prognostic performance than models with radiomics features or clinical data alone (C-index 0.790 vs. 0.675 vs. 0.736 in training cohort; 0.698 vs. 0.651 vs. 0.563 in validation cohort; AUC 0.761, sensitivity 56.7%, specificity 85.7%, p < 0.05 in training cohort and AUC 0.650, sensitivity 80.0%, specificity78.6%, p < 0.05 in validation cohort) When clinical data was combined with radiomics, an increase in the performance of the model was observed (NRI > 0). Conclusions: Radiomics features extracted from the PET and CT components of baseline 18F-FDG-PET/CT images may become an effective complement to provide prognostic information; therefore, radiomics features combined with clinical characteristic may provide clinical value for MM prognosis prediction.
An Overview of the Recent Advances in Composite Materials and Artificial Intelligence for Hydrogen Storage Vessels Design
Authors: Nachtane Mourad , Tarfaoui Mostapha , Abichou Mohamed amine , Vetcher Alexandre , Rouway Marwane , Aâmir Abdeouhaed , Mouadili Habib , Laaouidi Houda , Naanani Hassan
Published: March 2023

The environmental impact of CO2 emissions is widely acknowledged, making the development of alternative propulsion systems a priority. Hydrogen is a potential candidate to replace fossil fuels for transport applications, with three technologies considered for the onboard storage of hydrogen: storage in the form of a compressed gas, storage as a cryogenic liquid, and storage as a solid. These technologies are now competing to meet the requirements of vehicle manufacturers; each has its own unique challenges that must be understood to direct future research and development efforts. This paper reviews technological developments for Hydrogen Storage Vessel (HSV) designs, including their technical performance, manufacturing costs, safety, and environmental impact. More specifically, an up-to-date review of fiber-reinforced polymer composite HSVs was explored, including the end-of-life recycling options. A review of current numerical models for HSVs was conducted, including the use of artificial intelligence techniques to assess the performance of composite HSVs, leading to more sophisticated designs for achieving a more sustainable future.
Closed-Loop Recycling and Remanufacturing of Polymeric Aircraft Parts
Authors: Hyvärinen Marko , Pylkkö Mikko , Kärki Timo
Published: March 2023

The aviation industry is facing the challenge of reducing fossil fuels and emissions. Fuel efficiency is improved by making efficient powerplant systems and lighter aircraft. Modern passenger aircraft utilize polymeric and polymeric composite materials to achieve lighter structures without compromising strength. The European Union already has legislation to prevent landfilling and to increase the use of recyclable materials in the automotive industry. While older-generation aircraft, made mainly from metallic materials, are easily dismantled and recycled into other uses, such a process does not yet exist for aircraft made from composite materials. In the coming years, the industry will have to answer the question of how retired polymeric composite aircraft structures are to be recycled. One solution to increase the life cycle of polymeric and polymeric composite parts would be closed-loop recycling. In this paper, a perspective of the closed-loop recycling of polymeric aircraft parts is discussed. The technical aspects of recyclability and the different business models for the remanufacture of a finger pinch shroud certified for use in Airbus A350-900 passenger aircraft are investigated. The results show that closed-loop recycling is possible for polymeric aircraft parts. Future studies could include studying an LCA between virgin and recycled materials for a certain part.
Laser In Situ Synthesis of Gradient Fe-Ti Composite during Direct Energy Deposition Process
Authors: Shishkovsky Igor , Kakovkina Nina , Nosova Ekaterina , Khaimovich Alexander
Published: March 2023

The suitability of the direct energy deposition process of exothermic powders Fe-Ti in joining dissimilar metals to produce small parts of a complete shape for various applications is considered. The procedure of the direct energy deposition of commercial pure iron and titanium in various proportions and the modes of the process are described. Optical microscopy and SEM with EDX analysis, X-ray analysis, and microhardness measurements of laser-fabricated intermetallics are applied. Intermetallic compounds of FeTi, Fe2Ti, eutectoids, complex titanium oxides and nitrides, and iron carbides are found. Interlayer and trans-layer cracks and pores are observed. A microhardness growth from 150 HV to 900 HV was obtained for all samples due to the precipitation of brittle intermetallic phases in the gradient Fe-Ti system during the DED. The dispersion of microhardness values becomes significant in Ti-rich areas; there, pores and cracks are found. The revealed structure features are considered in relation to published results and explained. Increased concentrations of Ti to Ti + Fe = 3:1 on the Fe- and Fe + Ti -substrate with concentrations of Ti + Fe = 1:1 and Ti + Fe = 1:3 lead to increasing hardness and its distribution, but also increases in residual microstress. Recommendations are given to reduce the power during the direct energy deposition of titanium layers and to apply Fe-substrate, which can reduce residual stress, pores, and cracks.
Tribological Properties of Multilayer CVD Coatings Deposited on SiAlON Ceramic Milling Inserts
Authors: Osmond Luke , Cook Ian , Slatter Tom
Published: March 2023

This work characterises the structure and mechanical properties, such as adhesion, of two different chemical vapour deposition (CVD) coatings deposited onto silicon aluminium oxynitride (Si3N4 + Al2O3 + Y2O3) round (RNGN) milling cutter tooling inserts. These inserts are often known by the trade abbreviation “SiAlON”. Wear was produced on the inserts using unidirectional sliding (pin-on-disc type) and scratch testing. Two coatings were investigated: a multilayer CVD coating (Coating A) with a composition of TiN + TiCN + Al2O3 and a bilayer coating (Coating B) with a composition of Al2O3 + TiN. Microstructural analysis was conducted after wear testing and Coating B demonstrated high stability when subjected to high alternating shear and tensile stresses, high abrasion resistance and very high adhesion to the SiAlON ceramic insert substrate when compared to Coating A. Coating A demonstrated a low capacity to distribute alternating shear and tensile stresses during the pin-on-disc and scratch testing, which led to failure. The scratch and pin-on-disc results from this study correlate highly with completed machining insert wear analysis that has used Coating A and Coating B SiAlON inserts to machine aged Inconel 718.
Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature
Authors: Murray Jason , Lu Zhen A. , Miller Karin , Meadows Alex , Totten Marissa , Zhang Sean X.
Published: March 2023

Coinfection with invasive aspergillosis and mucormycosis in immunocompromised patients has been reported but is rarely confirmed by tissue histology or autopsy. Serum fungal biomarkers and culture are the primary diagnostic tools but are suboptimal for detecting fungal coinfection. Here, we present the cases of two patients who were immunocompromised due to hematologic malignancy where disseminated aspergillosis and mucormycosis coinfection was only diagnosed upon autopsy despite extensive fungal diagnostic workup, and also review recent literature of such instances of coinfection.
Development of a Multiplex qPCR Assay for Fast Detection and Differentiation of Paracoccidioidomycosis Agents
Authors: Pinheiro Breno Gonçalves , Pôssa Ana Paula , Ricci Giannina , Nishikaku Angela Satie , Hagen Ferry , Hahn Rosane Christine , de Camargo Zoilo Pires , Rodrigues Anderson Messias
Published: March 2023

Classic paracoccidioidomycosis (PCM) is a potentially deadly neglected tropical systemic mycosis caused by members of the Paracoccidioides brasiliensis complex (P. brasiliensis s. str., P. americana, P. restrepiensis, and P. venezuelensis) and P. lutzii. The laboratorial diagnosis of PCM relies on observing pathognomonic structures such as the “steering wheel” or “Mickey Mouse” shape in the direct mycological examination, fresh biopsied tissue in 10% KOH, histopathological analysis, and/or the isolation of the fungus in culture. However, these procedures are time-consuming and do not allow for the speciation of Paracoccidioides due to overlapping morphologies. Here, we propose a new one-tube multiplex probe-based qPCR assay to detect and recognize agents of the P. brasiliensis complex and P. lutzii. Primers (Paracoco-F and Paracoco-R) and TaqMan probes (PbraCx-Fam, Plu-Ned, and Paracoco-Vic) were developed to target the rDNA (ITS2/28S) in the Paracoccidioides genome. A panel of 77 Paracoccidioides isolates revealed a 100% specificity (AUC = 1.0, 95% CI 0.964–1.000, p < 0.0001) without cross-reacting with other medically relevant fungi or human and murine DNA. The lower limit of detection was 10 fg of gDNA and three copies of the partial rDNA amplicon. Speciation using qPCR was in perfect agreement with AFLP and TUB1-RFLP markers (kappa = 1.0). As a proof of concept, we assessed a panel of 16 formalin-fixed and paraffin-embedded specimens from histopathologically confirmed PCM patients to reveal a significant sensitivity of 81.25% and specificity of 100% (AUC = 0.906 ± 0.05, 95% CI = 0.756–0.979, p < 0.0001, Youden index J = 0.8125). Our assay achieved maximum sensitivity (100%) and specificity (100%) using fresh clinical samples (n = 9) such as sputum, bronchoalveolar lavage, and tissue fragments from PCM patients (AUC = 1.0, 95% CI 0.872–1.000, p < 0.0001, Youden index J = 1.0). Overall, our qPCR assay simplifies the molecular diagnosis of PCM and can be easily implemented in any routine laboratory, decreasing a critical bottleneck for the early treatment of PCM patients across a vast area of the Americas.
Conservation and Expansion of Transcriptional Factor Repertoire in the Fusarium oxysporum Species Complex
Authors: Yu Houlin , Yang He , Haridas Sajeet , Hayes Richard D. , Lynch Hunter , Andersen Sawyer , Newman Madison , Li Gengtan , Martínez-Soto Domingo , Milo-Cochavi Shira , Hazal Ayhan Dilay , Zhang Yong , Grigoriev Igor V. , Ma Li-Jun
Published: March 2023

The Fusarium oxysporum species complex (FOSC) includes both plant and human pathogens that cause devastating plant vascular wilt diseases and threaten public health. Each F. oxysporum genome comprises core chromosomes (CCs) for housekeeping functions and accessory chromosomes (ACs) that contribute to host-specific adaptation. This study inspects global transcription factor profiles (TFomes) and their potential roles in coordinating CC and AC functions to accomplish host-specific interactions. Remarkably, we found a clear positive correlation between the sizes of TFomes and the proteomes of an organism. With the acquisition of ACs, the FOSC TFomes were larger than the other fungal genomes included in this study. Among a total of 48 classified TF families, 14 families involved in transcription/translation regulations and cell cycle controls were highly conserved. Among the 30 FOSC expanded families, Zn2-C6 and Znf_C2H2 were most significantly expanded to 671 and 167 genes per family including well-characterized homologs of Ftf1 (Zn2-C6) and PacC (Znf_C2H2) that are involved in host-specific interactions. Manual curation of characterized TFs increased the TFome repertoires by 3% including a disordered protein Ren1. RNA-Seq revealed a steady pattern of expression for conserved TF families and specific activation for AC TFs. Functional characterization of these TFs could enhance our understanding of transcriptional regulation involved in FOSC cross-kingdom interactions, disentangle species-specific adaptation, and identify targets to combat diverse diseases caused by this group of fungal pathogens.
Prevalence of Cognitive Decline in Type 2 Diabetes Mellitus Patients: A Real-World Cross-Sectional Study in Mysuru, India
Authors: Kinattingal Nabeel , Mehdi Seema , Undela Krishna , Wani Shahid Ud Din , Almuqbil Mansour , Alshehri Sultan , Shakeel Faiyaz , Imam Mohammad T. , Manjula Santhepete N.
Published: March 2023

The goal of this research is to study the prevalence of cognitive impairment in diabetes mellitus (DM) patients and establish the necessity of detecting and treating it early in these patients. A cross-sectional study was conducted at a tertiary care hospital in Mysuru for 4 months examined diabetic patients (test) and nondiabetic subjects (control) for cognitive decline using the Montreal Cognitive Assessment (MoCA) tool. Cognitive functions such as visuospatial/executive function, naming, attention, language, abstraction, delayed recall, and orientation were assessed in both groups. The diabetic group showed a significantly lower total MoCA score than the non-diabetic group (18.99 ± 0.48 and 26.21 ± 0.46, respectively; p < 0.001). Assessment of scores in diabetic patients demonstrated the significant influence of age demographics on cognitive impairment (p-value < 0.001). Furthermore, a higher proportion of diabetic patients displayed cognitive impairment despite a higher score in a single subdomain, making it evident that diabetes is diverse and multifactorial in origin, where oxidative stress and inflammatory responses play a predominant role. This study suggested that the local T2DM population residing in Mysuru (India) has a high prevalence of cognitive impairment, evident from poor performance in almost all cognitive domains assessed by MoCA. Future studies could examine the generalizability of cognitive function findings in diabetic patients across diverse geographic regions and ethnic groups, as well as investigate interventions such as lifestyle modifications and medication to prevent or delay cognitive decline in those with diabetes.
White Matter Hyperintensities in Young Patients from a Neurological Outpatient Clinic: Prevalence, Risk Factors, and Correlation with Enlarged Perivascular Spaces
Authors: Zou Qiaoqiao , Wang Mingliang , Zhang Danni , Wei Xiaoer , Li Wenbin
Published: March 2023

(1) Background: to investigate the prevalence of white matter hyperintensities (WMH), risk factors, and correlation with enlarged perivascular spaces (ePVS) among young patients (age, 16–45 years) in a neurological outpatient clinic. (2) Methods: a total of 887 young patients who underwent a head magnetic resonance imaging (MRI)examination between 1 June 2021, and 30 November 2021, were included in this study. Paraventricular WMH (PWMH), deep WMH (DWMH), ePVS in the centrum semiovale (CSO-ePVS), and basal ganglia (BG-ePVS) were rated. Logistic regression analysis was used to identify the best predictors for the presence of WMH and, for the association of the severity of ePVS with the presence of WMH. Goodman–Kruskal gamma test was used to assess the correlation between the severity of ePVS and WMH. (3) Results: the prevalence of WMH was 37.0%, with low severity. Age, hypertension (p < 0.001), headache (p = 0.031), syncope (p = 0.012), and sleep disturbance (p = 0.003) were associated with the presence of DWMH. Age, sex (p = 0.032), hypertension (p = 0.004) and sleep disturbance (p < 0.001) were associated with the presence of PWMH. The severity of CSO-ePVS was associated with the presence and the severities of DWMH. The severity of BG-ePVS was associated with the presence and severities of DWMH and PWMH. (4) Conclusions: the prevalence of WMH was 37% and mild in young patients without specific causes. Older age, female, hypertension, headache, syncope, and sleep disturbance were associated with WMH. The severity of ePVS had an impact on the presence and severity of WMH in the corresponding brain regions.
Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study
Authors: Brunetti Valerio , Testani Elisa , Losurdo Anna , Vollono Catello , Broccolini Aldobrando , Di Iorio Riccardo , Frisullo Giovanni , Pilato Fabio , Profice Paolo , Marotta Jessica , Rollo Eleonora , Scala Irene , Calabresi Paolo , Della Marca Giacomo
Published: March 2023

Background: There is a growing body of evidence suggesting a link between obstructive sleep apnea (OSA) and atrial fibrillation (AF). The primary objective of this study is to evaluate the association between OSA and AF in acute ischemic stroke. The secondary objective is to describe the clinical features of patients with acute ischemic stroke and concomitant OSA. Methods: We enrolled consecutive patients with acute ischemic stroke. All patients underwent full-night cardiorespiratory polygraphy. To determine if there is an association between AF and OSA, we compared the observed frequency of this association with the expected frequency from a random co-occurrence of the two conditions. Subsequently, patients with and without OSA were compared. Results: A total of 174 patients were enrolled (mean age 67.3 ± 11.6 years; 95 males). OSA and AF were present in 89 and 55 patients, respectively. The association OSA + AF was observed in 33/174 cases, which was not statistically different compared to the expected co-occurrence of the two conditions. Patients with OSA showed a higher neck circumference and body mass index, a higher prevalence of hypertension and dysphagia, and a higher number of central apneas/hypoapneas. In the multivariate analysis, dysphagia and hypertension were independent predictors of OSA. A positive correlation was observed between OSA severity, BMI, and neck circumference. The number of central apneas/hypoapneas was positively correlated with stroke severity. Conclusions: Our data suggest that OSA and AF are highly prevalent but not associated in acute stroke. Our findings support the hypothesis that OSA acts as an independent risk factor for stroke.
Stock Portfolio Management by Using Fuzzy Ensemble Deep Reinforcement Learning Algorithm
Authors: Hao Zheng , Zhang Haowei , Zhang Yipu
Published: March 2023

The research objective of this article is to train a computer (agent) with market information data so it can learn trading strategies and beat the market index in stock trading without having to make any prediction on market moves. The approach assumes no trading knowledge, so the agent will only learn from conducting trading with historical data. In this work, we address this task by considering Reinforcement Learning (RL) algorithms for stock portfolio management. We first generate a three-dimension fuzzy vector to describe the current trend for each stock. Then the fuzzy terms, along with other stock market features, such as prices, volumes, and technical indicators, were used as the input for five algorithms, including Advantage Actor-Critic, Trust Region Policy Optimization, Proximal Policy Optimization, Actor-Critic Using Kronecker Factored Trust Region, and Deep Deterministic Policy Gradient. An average ensemble method was applied to obtain trading actions. We set SP100 component stocks as the portfolio pool and used 11 years of daily data to train the model and simulate the trading. Our method demonstrated better performance than the two benchmark methods and each individual algorithm without fuzzy extension. In practice, real market traders could use the trained model to make inferences and conduct trading, then retrain the model once in a while since training such models is time0consuming but making inferences is nearly simultaneous.
A Paradigm Shift towards Beneficial Microbes Enhancing the Efficiency of Organic and Inorganic Nitrogen Sources for a Sustainable Environment
Authors: Muhammad Haji , Fahad Shah , Saud Shah , Hassan Shah , Nasim Wajid , Ali Baber , Hammad Hafiz Mohkum , Bakhat Hafiz Faiq , Mubeen Muhammad , Khan Amir Zaman , Liu Ke , Harrison Matthew Tom , AbdElgawad Hamada , Abdel-Maksoud Mostafa A.
Published: March 2023

The use of beneficial microbes as biofertilizer has become fundamental in the agricultural sector for their potential role in food safety and sustainable crop production. A field trial was conducted to study the influence of beneficial microbes on the efficiency of organic and inorganic sources. The experiment was conducted in two consecutive years (2008–2009 and 2009–2010) in a farmer’s field at Dargai Malakand Division. A randomized complete block design was used with four replications. The results revealed a significantly higher straw and grain nitrogen concentrations for the treatments receiving 50% N from urea + 50% N from FYM + BM, followed by the treatments receiving 50% N from urea + 50% N from (FYM + PM) + BM and 120 kg N ha−1 from urea fertilizer, respectively. Comparing the relevant treatments with and without BM, an increasing trend in N concentrations in straw and grain was observed with BM. The results revealed the highest grain total nitrogen, straw total nitrogen and total nitrogen uptake by wheat crop for the treatments receiving 120 kg N ha−1 from urea, followed by the treatments receiving 50% N from urea + 50% N from PM + BM and 50% N from urea + 50% N from (FYM + PM) + BM. Moreover, after comparing the relevant treatments with and without BM, for the parameters mentioned, an increasing trend in nitrogen uptake was observed. Significantly higher total soil nitrogen was obtained for treatment with 50% N from urea + 50% N from FYM + BM, followed by the treatment with 50% N from urea + 50% N from (FYM + PM) + BM or 50% N from urea + 50% N from PM + BM, respectively, as compared to the control treatment plot. Markedly higher soil mineral nitrogen was obtained for the 50% N from urea + 50% N from (FYM + PM) + BM treatment, followed by the treatment with 50% N from urea + 50% N from FYM + BM and 50% N treatment from urea + 50% N from PM + BM, compared to the control treatment. Comparing the relevant treatments with and without BM, an increasing trend in total soil N (g kg−1 soil) and soil mineral N (mg kg−1 soil) was noted with BM application. From the results, a significant increase in soil organic matter status (g kg−1 soil) due to application of organic and inorganic fertilization was summarized. Significantly higher soil organic matter (g kg−1 soil) was recorded for the treatment receiving 50% N from urea + 50% N from FYM + BM compared to untreated control plots. Our study further revealed an increasing trend in soil organic matter status (g kg−1 soil) when comparing the relevant treatments with and without BM.
Industry 4.0 and Industrial Robots: A Study from the Perspective of Manufacturing Company Employees
Authors: Çiğdem Şemsettin , Meidute-Kavaliauskiene Ieva , Yıldız Bülent
Published: March 2023

Background: Human–robot collaboration is essential for efficient manufacturing and logistics as robots are increasingly used. Using industrial robots as part of an automation system results in many competitive benefits, including improved quality, efficiency, productivity, and reduced waste and errors. When robots are used in production, human coworkers’ psychological factors can disrupt operations. This study aims to examine the effect of employees’ negative attitudes toward robots on their acceptance of robot technology in manufacturing workplaces. Methods: A survey was conducted with employees in manufacturing companies to collect data on their attitudes towards robots and their willingness to work with them. Data was collected from 499 factory workers in Istanbul using a convenience sampling method, which allowed for the measurement of variables and the analysis of their effects on each other. To analyze the data, structural equation modeling was used. Results: The results indicate that negative attitudes towards robots have a significant negative effect on the acceptance of robot technology in manufacturing workplaces. However, trust in robots was found to be a positive predictor of acceptance. Conclusions: These findings have important implications for manufacturing companies seeking to integrate robot technology into their operations. Addressing employees’ negative attitudes towards robots and building trust in robot technology can increase the acceptance of robots in manufacturing workplaces, leading to improved efficiency and productivity.
Effect of Characteristic Parameters and Distribution of Friction Pair Surface Texture on Lubrication Properties
Authors: Qiang Haowen , Gao Guangming , Ye Sitong , Cheng Linkai , Wang Quandai
Published: March 2023

Based on the basic mechanism and bionics principle that texture affects the dynamic pressure effect of lubricating medium, a V-shaped texture that converges along the sliding direction is designed. Through numerical simulation, the optimal geometric parameters and distribution of the V-shaped and textures are obtained. A textured surface with various texture features is prepared using a nanosecond ultraviolet laser with bearing steel as substrate. Tribological experiments with friction and wear tester are performed to investigate the effect of characteristic parameters and distribution of surface texture on the lubrication performance and the lubrication properties are compared and analyzed with that of circular texture. Hence, this investigation provides a research direction to improve the lubrication performance between frictional pairs under fluid lubrication condition to reduce the frictional wear of mechanical systems. The results show that under the conditions of optimal parameters, due to the effect of convergence and extrusion on the flow of lubrication medium, the V-shape texture is better than the circular texture in improving the lubrication performance. The optimal characteristic parameters of V-shape texture are: 60° for the angle between the two wings, 0.53 for shape parameter, 25.9% for area ratio, 13 μm depth, 60% texture area coverage ratio, and the inlet of flow field of the texture distribution position.
Phase-Space Analysis of an Einstein–Gauss–Bonnet Scalar Field Cosmology
Authors: Millano Alfredo D. , Leon Genly , Paliathanasis Andronikos
Published: March 2023

We perform a detailed study of the phase-space of the field equations of an Einstein–Gauss–Bonnet scalar field cosmology for a spatially flat Friedmann–Lemaître–Robertson–Walker spacetime. For the scalar field potential, we consider the exponential function. In contrast, we assume two cases for the coupling function of the scalar field with the Gauss–Bonnet term: the exponential function and the power–law function. We write the field equations in dimensionless variables and study the equilibrium points using normalized and compactified variables. We recover previous results, but also find new asymptotic solutions not previously studied. Finally, these couplings provide a rich cosmological phenomenology.
Trajectories Generation for Unmanned Aerial Vehicles Based on Obstacle Avoidance Located by a Visual Sensing System
Authors: Muñoz Mendoza Luis Felipe , García-Torales Guillermo , Acosta Lúa Cuauhtémoc , Di Gennaro Stefano , Guillen Bonilla José Trinidad
Published: March 2023

In this work, vectorial trajectories for unmanned aerial vehicles are completed based on a new algorithm named trajectory generation based on object avoidance (TGBOA), which is presented using a UAV camera as a visual sensor to define collision-free trajectories in scenarios with randomly distributed objects. The location information of the objects is collected by the visual sensor and processed in real-time. This proposal has two advantages. First, this system improves efficiency by focusing the algorithm on object detection and drone position, thus reducing computational complexity. Second, online trajectory references are generated and updated in real-time. To define a collision-free trajectory and avoid a collision between the UAV and the detected object, a reference is generated and shown by the vector, symmetrical, and parametric equations. Such vectors are used as a reference in a PI-like controller based on the Newton–Euler mathematical model. Experimentally, the TGBOA algorithm is corroborated by developing three experiments where the F-450 quadcopter, MATLAB® 2022ª, PI-like controller, and Wi-Fi communication are applied. The TGBOA algorithm and the PI-like controller show functionality because the controller always follows the vector generated due to the obstacle avoidance.
Antioxidative Indenone and Benzophenone Derivatives from the Mangrove-Derived Fungus Cytospora heveae NSHSJ-2
Authors: Zou Ge , Li Taobo , Yang Wencong , Sun Bing , Chen Yan , Wang Bo , Ou Yanghui , Yu Huijuan , She Zhigang
Published: March 2023

Seven new polyketides, including four indenone derivatives, cytoindenones A–C (1, 3–4), 3′-methoxycytoindenone A (2), a benzophenone derivative, cytorhizophin J (6), and a pair of tetralone enantiomers, (±)-4,6-dihydroxy-5-methoxy-α-tetralone (7), together with a known compound (5) were obtained from the endophytic fungus Cytospora heveae NSHSJ-2 isolated from the fresh stem of the mangrove plant Sonneratia caseolaris. Compound 3 represented the first natural indenone monomer substituted by two benzene moieties at C-2 and C-3. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data, and the absolute configurations of (±)-7 were determined on the basis of the observed specific rotation value compared with those of the tetralone derivatives previously reported. In bioactivity assays, compounds 1, 4–6 showed potent DPPH· scavenging activities, with EC50 values ranging from 9.5 to 16.6 µM, better than the positive control ascorbic acid (21.9 µM); compounds 2–3 also exhibited DPPH· scavenging activities comparable to ascorbic acid.
New Insights in the Setting of Transplant Oncology
Authors: Quaresima Silvia , Melandro Fabio , Giovanardi Francesco , Shah Kejal , De Peppo Valerio , Mennini Gianluca , Ghinolfi Davide , Limkemann Ashley , Pawlik Timothy M. , Lai Quirino
Published: March 2023

Background and Objectives: Liver transplantation (LT) is the best strategy for curing several primary and secondary hepatic malignancies. In recent years, growing interest has been observed in the enlargement of the transplant oncology indications. This paper aims to review the most recent developments in the setting of LT oncology, with particular attention to LT for unresectable colorectal liver metastases (CRLM) and cholangiocellular carcinoma (CCA). Materials and Methods: A review of the recently published literature was conducted. Results: Growing evidence exists on the efficacy of LT in curing CRLM and peri-hilar and intrahepatic CCA in well-selected patients when integrating this strategy with (neo)-adjuvant chemotherapy, radiotherapy, or locoregional treatments. Conclusion: For unresectable CCA and CRLM management, several prospective protocols are forthcoming to elucidate LT’s impact relative to alternative therapies. Advances in diagnosis, treatment protocols, and donor-to-recipient matching are needed to better define the oncological indications for transplantation. Prospective, multicenter trials studying these advances and their impact on outcomes are still required.
Clinical and Radiographic Evaluation of Third-Generation Pericardium Membrane for the Treatment of Grade II Furcation Defect in Stage III Periodontitis Patients
Authors: Elboraey Mohamed O. , Mously Eihab A.
Published: March 2023

Background and Objectives: Guided tissue regeneration, with or without a bone graft, is a modality for the treatment of furcation involvement. Because the direct application of a bone graft into the periodontal defect has drawbacks, such as the risk of microbial contamination and/or graft containment, a new modality of directly loading bone graft particles over the barrier membrane is now used. This study aimed to evaluate clinically and radiographically the effects of a two-layered membrane consisting of a layer of nanohydroxyapatite particles on a pericardium membrane in the treatment of stage III periodontitis, compared with direct application of a nanohydroxyapatite bone graft. Materials and Methods: Forty individuals with grade II furcation involvement were divided into two groups. Group I was treated with a two-layered membrane consisting of a pericardium membrane with nanohydroxy particles loaded onto its surface; group II was treated with direct application of a nano bone graft covered with pericardium membrane. Clinical and cone beam computed tomography (CBCT) radiographic assessments of the two groups were carried out after a 6-month follow-up period. Results: Clinically, the results showed a significant reduction in furcation involvement (F). The CBCT assessment also revealed reductions in depth (D), height (H), width (W), and 3D radiographic volume of furcation involvement in all study groups at baseline and at 6 months postoperative (p < 0.05) with no significant differences between groups. Conclusions: According to the results of the current study, a two-layer membrane formed by direct loading of bone graft particles onto a pericardium membrane can be used as an effective, reliable, and easy-to-use substitute for direct bone graft application into periodontal defects.
Colitis as the Main Presentation of COVID-19: A Case Report
Authors: Frič Vlasta Oršić , Borzan Vladimir , Borzan Andrej , Kiš Izabela , Dmitrović Branko , Roksandić-Križan Ivana
Published: March 2023

The main symptoms of coronavirus disease (COVID-19) are fever, cough, tiredness, and loss of smell and taste. Gastrointestinal symptoms are less common. A 38-year-old female patient, previously healthy, presented with a history of hematochezia up to 8 times per day, followed by abdominal cramps, urgency, and chills for two days. She did not have any respiratory symptoms and was previously vaccinated for COVID-19. She was afebrile, with normal vital signs. Blood samples showed normal complete blood count and increased C-reactive protein (CRP), fibrinogen, and D-dimer levels (66 mg/L, 4.1 g/L, and 2302 μ/L FEU, respectively). Stool samples for stool culture, C. difficile, and viral examination came back negative. On day 3, she reported a mild cough, fever and loss of smell and taste. Nasopharyngeal swab for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) PCR test came back positive. On day 6, the patient still had hematochezia accompanied by abdominal cramps, but fever and respiratory symptoms withdrew. CRP, fibrinogen, and D-dimers were still elevated, as well as liver enzyme levels. Sigmoidoscopy was performed with biopsies taken from sigmoid and rectum for histology and PCR SARS-CoV-2 testing. CT angiography showed no signs of thrombosis in mesenteric veins or arteries. PCR test for SARS-CoV-2 virus from rectal biopsy sample was positive. Patient was treated with methylprednisolone iv for two days and peroral prednisone afterwards, with mesalamine, metronidazole and enoxaparin. Sigmoidoscopy was repeated after two weeks showing only mild hyperemia. At that time, the patient had normal stool, normal CRP, liver enzyme, fibrinogen, and D-dimer levels, and normocytic anemia (hemoglobin level of 103 g/L). We wanted to show that severe gastrointestinal symptoms, such as hemorrhagic colitis, can be the main presentation of COVID-19, even in young patients with no prior comorbidities. In such a case, PCR test in biopsy samples can be performed to prove SARS-CoV-2 infection of bowel mucosa.
Techno-Economic Analysis of Vacuum Membrane Distillation for Seawater Desalination
Authors: Idrees Hassaan , Ali Sara , Sajid Muhammad , Rashid Muhammad , Khawaja Fahad Iqbal , Ali Zaib , Anwar Muhammad Nabeel
Published: March 2023

Seawater desalination is an affordable and viable solution to the growing freshwater scarcity problem in water scarce regions. The current study focuses on cost analysis of Vacuum Membrane Distillation (VMD) setup for removing salts from water. The membrane used in the flat sheet VMD module was Polytetrafluoroethylene (PTFE) with 250 mm × 200 mm dimensions and 165 µm thickness. The experiments were carried out with variations in parameters such as velocity, pressure, concentration, and temperature. For the cost analysis, the operational, maintenance, instrumentation, and capital cost of the lab model was considered and then upscaled. A range of experiments was performed for NaCl and KCl under variations of operating parameters. It was noted that, for the NaCl solution, the increase in temperature from 50 °C to 70 °C doubled the permeate flux. However, for the conditions tested, the concentration shift from 0.25 M to 0.75 M decreased the permeate flux by 1.4% because the increase in ion concentrations along the membrane lowers the vapor pressure, restricting the permeate flux. The results trend for the KCl solution was similar to the NaCl; at temperature T1, it was noted that increased concentration from 0.25 M to 0.75 M significantly reduces the permeate flow. The reduction in permeate flow was nonlinear for a given pressure 30 kPa and velocity 5.22 m/s, but linear for all other variables. It was also observed that with an increase in temperature from 60 °C to 70 °C, the permeate flux for concentration 0.25 M was 49% for all the combinations of pressure and velocity. In addition, permeate flow increased 53% from temperature 50 °C to 60 °C and 49% from temperature 60 °C to 70 °C for both the solutions at a concentration of 0.25 M. This shows that the temperature also had a profound impact on the permeate flux. The economic analysis and market survey shows that the cost of clean water at the lab level was high which can be significantly reduced using a large-scale setup providing 1,000,000 L/H of distilled water.
Chemical Inhomogeneity from the Atomic to the Macroscale in Multi-Principal Element Alloys: A Review of Mechanical Properties and Deformation Mechanisms
Authors: Zhu Jiaqi , Li Dongfeng , Zhu Linli , He Xiaoqiao , Sun Ligang
Published: March 2023

Due to their compositional complexity and flexibility, multi-principal element alloys (MPEAs) have a wide range of design and application prospects. Many researchers focus on tuning chemical inhomogeneity to improve the overall performance of MPEAs. In this paper, we systematically review the chemical inhomogeneity at different length scales in MPEAs and their impact on the mechanical properties of the alloys, aiming to provide a comprehensive understanding of this topic. Specifically, we summarize chemical short-range order, elemental segregation and some larger-scale chemical inhomogeneity in MPEAs, and briefly discuss their effects on deformation mechanisms. In addition, the chemical inhomogeneity in some other materials is also discussed, providing some new ideas for the design and preparation of high-performance MPEAs. A comprehensive understanding of the effect of chemical inhomogeneity on the mechanical properties and deformation mechanisms of MPEAs should be beneficial for the development of novel alloys with desired macroscopic mechanical properties through rationally tailoring chemical inhomogeneity from atomic to macroscale in MPEAs.