bluuebunny/crossref_metadata_2025 huggingface dataset:
Bridging physical and virtual ecologies of action: giving and following instructions in co-located VR-gaming sessions
Authors: Olbertz-Siitonen Margarethe , Piirainen-Marsh Arja
Published: October 2023

Using multimodal conversation analysis, this study examines how communicative practices are adapted to the affordances for interaction in co-located encounters where participants are getting acquainted with VR-technology and games. The analysis focuses on instructional activities and investigates how an expert player guides others in learning how to handle VR equipment and getting to know the game mechanics during the initial moments of starting a new game.

The data comprises video-recordings of informal social gatherings of 3-4 young adults who take turns in trying out different VR games. The gaming situations were organized in a temporary game lab using consumer-grade VR equipment, a large screen that displayed video feed from the game console and loudspeakers for the game sound.

The analysis demonstrates how the experienced player who has no direct agency over the virtual world uses verbal and carefully placed tactile means to help novice players (who in turn have restricted access to the material world) navigate the initial stages of entering a game. Their complying actions, on the other hand, are characterized by finely tuned bodily adjustments in interplay with affordances of the technology. The instruction sequences, therefore, represent interactional moments in which the participants mutually attend to asymmetries, orienting to bridging physical and virtual ecologies of action.
PERANAN EDITOR DALAM PEMBUATAN FILM DOKUMENTER PROFESI “TUKANG DO’A” YANG BERJUDUL “MENCARI SESUAP NASI DENGAN MENJADI TUKANG DO’A”
Authors: Kusuma Dafa Ramadhan , Dianta Arrya
Published: October 2023

Profesi Tukang Do’a kubur merupakan salah satu profesi yang ada diindonesia. Profesi inidilakukan oleh orang-orang yang memegang teguh latar belakang dari segi agama nya.Jasa pembawa doa yang lebih sering dikenal dengan Tukang Do’a yaitu profesi yangmenawarkan jasa nya kepada orang-orang peziarah untuk dibacakan do’a di pusara makamsanak saudara. Biasa nya pekerjaan jasa pembawa do’a ini ramai bermunculan saatmoment bulan Ramadhan tiba. Dan ramainya orang pergi ke makan untuk berziarah tidakselalu ramai setiap hari, hanya bisa melihat dari musim dan bulan saja, maka dari itupencipta membuat sebuah film documenter tentang profesi “Mencari Sesuap Nasi DenganMenjadi Tukang Do’a”. dalam penciptaan karya ini, penulis bertugas sebagai KreatifEditor yang bertanggung jawab atas segala kesuluruhan pada tahap final film documenterini, meyusun dan menyunting gambar audio maupun visual. Dengan Film dokumenter inipenulis berharap film ini dapat dijadikan sebagai salah satu sumber yang informatif,edukatif serta bisa memotivasi bagi yang melihat karya ini. Profesi yang bahkan tidakterpikirkan bisa juga dijadikan sebagai sumber penghasilan seseorang. Alasan penciptakarya membuat film dokumenter ini, karena masih banyak yang belum sadar akan profesijasa pembawa do’a ini, Banyak tayangan di sosial media terlebihnya di youtube sangatdominan dengan tayangan yang menghibur, dan tentunya masih sedikit pula tayangan yangmenampilkan fenomena yang lahir dari kisah nyata kehidupan seseorang dengan profesinya yang belum banyak diketahui oleh khalayak. Salah satunya adalah kisah perjuanganhidup seorang jasa pembawa doa yang mampu menghidupi keluarga nya dengan profesitersebut. Metode yang di gunakan dalam karya ini, yaitu kualitatif dengan teknikpengumpulan data survey lokasi, observasi serta melakukan wawancara dengannarasumber. Dalam penciptaan karya ini, pencipta karya berharap, film dokumenter“Mencari Sesuap Nasi Dengan Menjadi Tukang Do’a” ini dapat menjadi alternatif pilihantayangan edukatif dan informatif bagi masyarakat Indonesia.
Pengaruh Program Habituasi terhadap Kondusifitas Lingkungan Sekolah
Authors: Iqbal Muhammad , Watun Baiq Ririn Rizza , Hariawan Rudi , Fahmi Agus
Published: October 2023

This study aims to determine the effect of the habituation program on the conduciveness of the school environment at SMA Negeri 1 Sikur East Lombok. The population in this study were students of class X and XI. The data analysis technique used in this study was descriptive statistics and simple regression analysis. The results of this study indicate that the habituation program has a significant effect on the conduciveness of the school environment. This is evidenced by the analysis results obtained that the r-count value (0.73) is greater than the r-table value (0.53). The results of the regression equation analysis obtained a value of 3.19 while the F-count value was obtained at 112.891 and the t-count value was obtained at -0.96 with a significance level of 0.000 > 0.05. The R2 value was obtained at 0.535 or 53.5%. This shows that there are other factors that affect 46.5% which are not discussed or examined in this study. Based on these results, it means that the proposed hypothesis is accepted or Ho is rejected and Ha is accepted which reads that the habituation program has a significant effect on the conduciveness of the school environment in SMA Negeri 1 Sikur, East Lombok.
TEKNIK KONSELING BERDASARKAN PERSPEKTIF QS. YUNUS AYAT 57
Authors: Fitriani Diah Nurul
Published: October 2023

Penulisan artikel ini dilatar belakangi oleh banyaknya permasalahan yang terjadi di sekolah maupun di lingkungan masyarakat salah satunya adalah perilaku bermasalah yang tentunya kurang baik pada siswa. Seorang siswa yang dikategorikan sebagai siswa yang memiliki problem apabila siswa tersebut menunjukkan gejala-gejala penyimpangan dari perilaku atau norma-norma yang lazim dilakukan oleh anak-anak pada umumnya. Oleh karena itu layanan konseling dalam hal ini sangat diperlukan. Layanan konseling mempunyai peran dan fungsi sebagai pembimbing yaitu membantu siswa untuk menghadapi kekurangannya. Tujuan penulisan artikel ini adalah untuk mengetahui teknik konseling dalam tafsir Ibnu Katsir QS. Yunus ayat 57. Penulisan artikel ini merupakan penelitian pustaka. Dalam mengumpulkan data yang diperoleh melalui pengamatan buku-buku, jurnal, artikel, karya ilmiah atau majalah yang ada di perpustakaan yang relevan dengan problematika yang dibahas. Sumber data dari penulisan artikel ilmiah ini terdiri dari sumber data primer dan sekunder. Sumber data primer meliputi Al-Qur’an dan kitab-kitab Tafsir sedangkan sumber data sekunder yaitu buku dan jurnal yang mendukung sumber data primer. Hasil dari penulisan artikel ini menunjukkan tafsir Ibnu Katsir dalam Qs. Yunus ayat 57 menjelaskan bahwa ayat ini merupakan petunjuk dari Allah SWT kepada umatnya bahwa Al-Qur’an diturunkan kepada manusia sebagai pengajaran atau pemberi nasihat, obat penyembuh, petunjuk serta pemberi rahmat. Konsep bimbingan dan konseling Islam yang terkandung dalam Qs. Yunus ayat 57 dalam tafsir Ibnu Katsir meliputi penyadaran dengan menggunakan metode pemberian nasihat, pengobatan sebagai langkah untuk menyembuhkan, penalaran logis dengan memberikan petunjuk kepada siswa bermasalah. Konsep tersebut dapat diterapkan dalam layanan konseling untuk menangani siswa bermasalah. Sehingga dengan menerapkan konsep pelayanan tersebut akan membantu siswa untuk mengatasi problematikanya sehingga dapat mendapatkan ketenangan dan kenyamanan.
PENGGUNAAN METODE TALKING STICK UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATA PELAJARAN IPA KELAS VI DI SDN MERTAK PAOK
Authors: Irfan Ahmad Zainul
Published: October 2023

Berbagai cara dan metode dilakukan oleh guru dalam kegiatan belajar mengajar untuk menyampaikan informasi agar efektif dapat diterima oleh siswa. Namun, seefektif apapun penyampaian materi pelajaran oleh guru, tidak semuanya dapat diterima oleh siswa. Ketika pemahaman siswa dirasa masih belum maksimal, tentu seorang guru harus memikirkan cara agar siswa dapat berlatih lebih banyak tentang materi tersebut. Penelitian tindakan kelas ini dilaksanakan pada kelas VI SDN Mertak paok.  Subjek penelitian berjumlah 18 siswa. Penelitian ini dilakukan sebanyak dua siklus. Tujuan dalam penelitian tindakan kelas ini adalah sebagai berikut: (1) Untuk mengetahui dan mendeskripsikan penerapan pembelajaran IPA dengan metode Talking Stick pada siswa kelas VI SDN Mertak paok. (2) Untuk mengetahui dan menjelaskan peningkatan hasil belajar siswa pada mata pelajaran IPS dengan menerapkan metode Talking Stick pada siswa kelas VI SDN Mertak paok. Metode penelitian yang digunakan adalah metode kualitatif yaitu penelitian ini akan mendiskripsikan peristiwa yang terjadi dalam bentuk kalimat, untuk melengkapi data kualitatf digunakan juga data kuantitaif yaitu untuk mengukur hasil belajar siswa yang diperoleh dari hasil tes yang diberikan pada siswa. Data kuantitaif berupa angka hasil belajar siswa, sedangkan data kualitatif merupakan ungkapan yang menunjukkan tentang proses dan hasil belajar yang diperoleh siswa. Hasil penelitian menunjukkan siswa lebih semangat dan antusias dalam mengikuti pembelajaran dengan penerapan metode Talking Stick karena menunjang keberlangsungan pembelajaran sehingga meningkatkan hasil belajar siswa pada mata pelajaran IPA (Ilmu Pengetahuan Alam). Hasil belajar yang diperoleh siswa mengalami peningkatan, dari siklus I sebesar 58% meningkat menjadi 84% pada siklus II. Penerapan metode Talking Stick diharapkan dapat digunakan kembali untuk semua jenjang kelas, karena dalam penelitian ini membuktikan adanya peningkatan hasil belajar IPA pada siswa kelas VI SDN Mertak paok.
AKARYAKIT İSTASYONUNDA ÇALIŞANLARIN KİMYASALLARA MARUZİYETİ
Authors: ŞENTÜRK Kerem , KARAHALİL Bensu
Published: October 2023

Amaç: Günümüzde sayıları her geçen gün artan kimyasal maddeler hem hayatımızı kolaylaştırmakta hem de olumsuz sağlık etkilerine neden olabileceği için endişe yaratmaktadır. Kimyasalların olası sağlık risklerini minimize ederek kullanmak için iyi yönetilmesi gerekmektedir. Kimyasallara akut maruziyetten ziyade kronik maruziyet daha tehlikeli sonuçlar doğurabilir. Kronik maruziyet mesleki maruziyette de görülmektedir. Sunulan derleme makalesinde akaryakıt istasyonlarında maruz kalınan kimyasallar ve özellikleri, bu kimyasallara mesleki maruziyetin sebep olacağı olası sağlık etkileri ve olumsuz sağlık etkilerini minimize etmek için gerekli önlemlerden bahsedilmiştir.
Sonuç ve Tartışma: Akaryakıt istasyonlarında özellikle benzin, motorin ve LPG gibi satış ürünleri bulunmaktadır ve bunlar çeşitli kimyasal maddeler içermektedir. Benzen, toluen, etilbenzen ve ksilen başlıca maruz kalınan maddelerdir. Benzen Uluslararası Kanser Araştırma Ajansı (IARC) tarafından Grup 1 “insan karsinojeni” ve etilbenzen Grup 2B “olası insan karsinojeni” olarak sınıflandırılmıştır. Akaryakıtta bulunan bu maddelere başta inhalasyon ve dermal yolla maruziyet söz konusudur. Regülasyonlarla belirlenen limit değerlere uyulduğu ve yapılan işe göre eldiven, maske ve iş kıyafeti gibi koruyucu önlemler alındığında olası sağlık riskleri azaltılabilir. Birçok çalışmada akaryakıt istasyonunda çalışan ve çalışmayan bireyler karşılaştırılarak özellikle korunma önlemi almayan bireylerde maruziyet grubunda ciddi sağlık sorunları gözlenmiştir. Bu nedenle koruyucu önlemlerin sıkı olarak uygulanması ve iş yeri hava ölçümleri yapılarak havadaki kimyasalların limit değerleri aşmadığının denetlenmesi gerekmektedir.
An Analysis of Lexicons in Costumes of Baris Gede Dance at Penuktukan Village
Authors: Aprilianti Luh Wulan
Published: October 2023

This research aims to find out the lexicons and the cultural meaning in the costumes of the Baris Gede dance. Baris Gede dance is a traditional Balinese dance that tells about warriors fighting on the battlefield. Costumes are an important component in the Baris Gede dance because the costumes used represent the contents of the dance. This research used qualitative research with interviews and observation as the method to obtain the data. The researcher found 14 lexicons in the costumes; head costume (1 lexicon) that is gelungan, neck costume (1 lexicon) which is badong/bapang, hand costume (1 lexicon) which is gelang kana, upper body costume (7 lexicons) which are awiran, oncer, lamak, kwace selem, tali semayut, keris, and urangka and lower body costume (4 lexicons) that are stewel, jaler putih, kancut putih, and sabuk. The cultural meaning relates to the soldiers on the battlefield. Warriors are depicted as dashing and brave figures represented through the Baris Gede dance costume.
Teachers’ and Students’ Perception of Animation Video by Animaker in Blended Learning
Authors: Kartika Yasa I Gede Bayu
Published: October 2023

In the post-COVID-19 pandemic era, the learning style of young learners has changed from online learning to blended learning. It means that young learners must adapt to face-to-face and online learning. It also causes the teacher to prepare on how to make effective blended learning, which demands the teacher to prepare the learning material both in face-to-face and online learning. In addition, in teaching young English learners, especially young learners, the learning media used must be exciting and compelling. Currently, the use of animation videos is constructive for young learners during the COVID-19 pandemic because the contents are delivered to keep them learning even if they learn independently. This study aims to delve into the teachers’ and students’ perceptions of the use of animation videos by Animaker as learning media in blended learning in the post-pandemic era. This study used a descriptive qualitative method explained through in-depth interviews with two teachers and ten EFL students in an elementary school. The result explained that audio-visual media in the form of animation videos by Animaker effectively to be used in blended learning. Because the animation videos were attractive, the students were motivated to learn. The implementation was also flexible that could be learned anytime and anywhere. However, some platform limitations, such as limited export time and limited characters used for free users, became a disadvantage. This article is expected to help teachers develop engaging learning media that motivate young learners.
Writing Error: Exploring the Language Interference in EFL Context
Authors: Hikmah Durratul , Wahyudi Irfan
Published: October 2023

Al-Mashduqiah Plus Junior High School is one of the boarding school that develops foreign language skills as an attempt to prepare young people to be able to compete in the global world. In fact, the language learners (students) still often mix the structure of their first language into English to write. Therefore, this study aimed to identify the language interference in the students’ English writing assignment, and what factors behind them. The research used descriptive qualitative. The results showed that the form of interference in Al- Mashduqiah Plus Junior High School is morphological and syntactical structure. Besides, these interferences are caused by several factors; they are structural and non-structural factors. The structural factors include the difference of linguistics systems in native language and the targeted language. The non-structural factors include the learners’ bilingualism, language loyalty, the inadequate vocabulary of learners’ language, and the habits of using mother tongue language. This research is expected to provide information to students, teachers, and researchers so that they can find learning innovations that can improve the quality of foreign language skills.
“Afghan” in Afghanistan: Idols in the Land of Idols
Authors: Jamil Hanifi M.
Published: October 2023

A perennial anomaly in the academic, political, and popular discourse about “Afghan” and “Afghanistan” is the chronic absence of an informed and systematic engagement with the epistemology and semantic construction of the Persian identity label “Afghan” and its derivative use in the cultural, political, social, and spatial configuration of “Afghanistan.” This article offers a brief overview of, and a corrective to, this cultural and linguistic disposition. The essay examines the widespread use, the cultural and historical roots, and linguistic seeds of the ethnonym “Afghan” and its derivative toponymal “Afghanistan.” The essay excavates the Buddhist stance and the epistemological cradle of the Persian morpheme from which the term “Afghan” is derived. This exercise in the ethnology of Afghanistan locates the country and its people in historical “deep time” and in the context of several cultural layers and processes rather than a cultural construct in isolation. It aims to serve as a springboard for a corrective etymological awareness for the production of academic and political texts and discourse dealing with Afghanistan and its people.
Analysis of working conditions, social status and health of migrant worker
Authors: Orlova N. V. , Fedulaev Yu. N. , Arakelov S. E. , Titova I. Yu. , Shchepetin N. V. , Shurygina N. V. , Plusheva A. V.
Published: October 2023

Labor migration has socio-economic significance in the interests of both the host country and the country of origin. Difficult working conditions, unfavorable living conditions increase the risk of developing diseases. An analysis of the health status of migrant workers in different countries revealed that infectious diseases, injuries, including industrial, acute intoxication and acute surgical pathology are most common. Women’s health requires special attention. A study conducted at the GBUZ «GCB No. 13 DZM» revealed that the largest number of patients were from Kyrgyzstan, Tajikistan, Uzbekistan. Acute surgical pathology, injuries, gynecological diseases prevail among the reasons for hospitalization. Among the diseases of the therapeutic profile, cirrhosis, hepatitis, acute intoxication, diseases of the urinary and reproductive system, diseases of the circulatory system and cerebrovascular diseases are most common. Attention is drawn to the short period of stay in the hospital –2.4 days. Russia has taken measures aimed at preserving the health of migrant workers. Since December 2021, a medical examination has become mandatory. The developed measures to improve the quality of medical examinations of migrant workers are aimed at early detection and prevention of diseases.
Anxiety and sleep disorders in general practice
Authors: Polyakova O. A. , Ebzeeva E. Yu. , Dubinina A. V. , Telkova S. S. , Asoskova A. V. , Kozgunova L. D. , Ostroumova O. D.
Published: October 2023

Anxiety and sleep disorders are an urgent problem of modern healthcare, which should be treated at the earliest possible stages, since this would prevent the development of a wide range of complications of these conditions. At the same time, given the bidirectional relationship between anxiety and sleep disorders, the search and development of safe and effective remedies for their correction is becoming increasingly relevant. The prescription of a set of measures of nonmedicamental and medicamental nature is considered to be the main methods of therapy for anxiety and sleep disorders. This article presents diagnostic tools that allow the general practitioner to identify anxiety and sleep disorders (insomnia) in a patient as early as possible, and discusses the therapeutic strategies for using a combination of glycine and melatonin in appropriate patients.
«Locomotive syndrome» in patients in the geriatric hospital
Authors: Topolyanskaya S. V. , Romanova M. A. , Vakulenko O. N. , Bubman L. I. , Eliseeva T. A. , Larina D. S. , Ratchina S. A. , Dvoretski L. I.
Published: October 2023

The study aim was to analyze the prevalence and course of locomotive syndrome in patients in the geriatric hospital.

Materials and methods. This work was a cross-sectional study performed on the basis of the Moscow War Veterans Hospital N3. The study enrolled 58 patients – 43 women (74.1%) and 15 men (25.9%) hospitalized in the geriatric department of the hospital. The mean age of study patients was 82.7+5.9 years, varying from 75 to 96 years. A comprehensive geriatric assessment was performed, including the Age Is Not a Barrier Questionnaire, the Basic Daily Activity Scale (Bartel Index), the Instrumental Activities of Daily Living (IADL) Scale, and the Morse Falls Scale. Questionnaires were filled out to assess the locomotive syndrome – GLFS‑5 and GLFS‑25. A 2 step test was carried out.

Results. In 48 out of 58 patients (82.8%), locomotive syndrome was found: in 88.4% of women and in 66.7% of men (p=0.05). Locomotive syndrome was diagnosed in all centenarians, in 82.7% of patients aged 80 to 89 years and in 75% of patients aged 75–79 years. The main cause of the locomotive syndrome was degenerative-dystrophic changes in the spine and joints observed in all patients. Only 1 patient had stage I locomotive syndrome, all the rest had stage II. Patients with locomotive syndrome had lower levels of activity in everyday life – 84.3±11.2 and 93.0±6.3 points according to the Barthel index, respectively (p=0.01), greater severity of pain syndrome according to VAS – 4.2±1.8 and 1.7±1.6 points, respectively (p=0.003) and a shorter distance of 2 steps (123.3±30.9 and 148.1±20.7 cm, respectively (p=0.003). Direct correlations were established between the values of the GLFS‑5 locomotive function scale and the age of patients (r=0.33; p=0.01), as well as the severity of chronic pain syndrome according to VAS (r=0.55; p=0.00007). Inverse relationships were registered between the indicators of the GLFS‑5 scale and the Barthel index (r= –0.44; p=0.0005), the IADL scale (r= –0.41; p=0.001) and the distance traveled in the «2 steps» test (r= –0.52; p=0.0007). Inverse correlations were observed between the values of the GLFS‑25 scale and the Barthel index (r= –0.41; p=0.008), the IADL scale (r= –0.59; p=0.00008), the Mini-COG test (r= –0.37; p=0.02), as well as indicators of bone mineral density in the proximal femur (r= –0.39; p=0.04 – r= –0.54; p=0.002). Conclusions. The study results indicate that patients in the geriatric hospital very often have locomotive syndrome associated with the pathology of the musculoskeletal system. The severity of the locomotive syndrome correlates with the indicators of the functional activity of patients, the intensity of the pain syndrome and the bone mineral density.
Prevalence of risk factors for cardiovascular diseases among medical university students
Authors: Orlova N. V. , Sapozhnikov S. A. , Bogdanov A. R.
Published: October 2023

An online survey of students of higher educational institutions was conducted to study the spread of smoking, obesity, physical inactivity. A comparison was made between students of medical and non-medical universities. It was revealed that 21% of physicians smoke, 47% of non– medical students. Among medical university students, 18% were overweight, and 75% were irrational eating with fast food consumption. Irrational nutrition (insufficient or excessive nutrition) was also common among students. The number of students engaged in sports sections or having a subscription to fitness clubs, respectively, was 11% and 23%. The percentage of students with low physical activity in medical and non-medical universities did not have a statistically significant difference and was less than 20%. The most popular classes that evoked positive emotions among students were sports games: volleyball, basketball, badminton. The girls positively assessed gymnastics classes. Among the factors influencing motivation to study in sports sections, the possibility of improving sports skills and participation in competitions was indicated. Students expressed satisfaction with classes in health groups, the program of which took into account the individual characteristics and capabilities of the individual. Physical inactivity and poor nutrition are related behaviors that affect health and well – being, as well as maintaining a healthy weight. The results of the study showed the need for comprehensive measures to increase the motivation of medical university students to a healthy lifestyle.
Extemporal production of medicines – advantages and prospects
Authors: Orlova N. V. , Ilyenko L. I.
Published: October 2023

Extemporal drugs are an important component in pharmaceutical practice, allowing the provision of dosage forms or dosages that are not commercially available, and the personification of drug therapy. These drugs are most in demand in pediatrics, gerontology, oncology, palliative medicine, dermatology. A number of measures are necessary for the introduction of extemporal production of medicines into modern practical medicine: changing regulatory legal acts regulating the manufacture of extemporal medicines; improvement of modern methods of quality control; updating of the collection of extemporal medicines; ensuring the introduction of the use of extemporal medicines in practical healthcare; modernization of pharmacy equipment; organization of advanced training of medical and pharmaceutical specialists in the field of prescribing, manufacturing complex dosage forms in pharmacies and control of their production.
Mesleki Tatmin, Mesleki Bağlılık ve Örgütsel Bağlılık Arasındaki İlişkiler: Mali Hizmetler Uzmanlığı Kariyer Mesleği Üzerine Bir Araştırma
Authors: DEMİREL Abdullah , SEVİNÇ İsmail
Published: October 2023

Bu çalışmada, kamuda kariyer uzmanlık sistemi içerisinde yer alan ve yapılan bazı düzenlemeler sonucunda (eşit işe eşit ücret vb.) özlük hakları diğer kariyer uzmanlık mesleklerinden daha düşük tutulan tek merkez kariyer personeli olan ve genel yönetim kapsamındaki kamu idarelerinin merkez teşkilatlarında görev yapan mali hizmetler uzmanlarının, mesleki tatmin, mesleki bağlılık ve örgütsel bağlılıkları arasındaki ilişkiler sosyo-demografik özellikler ile birlikte incelenmiştir. Çalışma sonucunda, mali hizmetler uzmanlarının mesleki tatmin düzeyinin orta düzeyde olduğu, mesleki bağlılıkları ile örgütsel bağlılıklarının daha düşük olmakla birlikte, mesleki bağlılıklarının ise örgütsel bağlılığa göre daha yüksek olduğu görülmüştür. Bununla birlikte mesleki tatmin ile mesleki bağlılık, örgütsel bağlılığı oldukça önemli bir oranda ve pozitif yönde etkilediği sonucuna ulaşılmıştır. Ayrıca mesleki tatminin, mesleki ve örgütsel bağlılık düzeylerinin anlamlı olarak bazı sosyo-demografik özelliklere (yaş, kıdem, öğrenim durumu vb.) göre de değişkenlik gösterdiği belirlenmiştir.
WORLD RELIGION, POLITICS AND HUMAN DEVELOPMENT
Authors: Tikhute Vishal
Published: October 2023

The relationship between religion and politics continues to be an important theme in political philosophy. In many developing countries, religion has a huge impact on human development. The public domain data of UNDP and Central Intelligence Agency (CIA) were analyzed to describe linkages between religion and the human development index (HDI) across 182 nations. The secondary data on religious majority in each country and HDI ranks for year 2018 were compiled and analyzed. Descriptive statistics was used to present the results. The analysis found that religion and human development were closely interconnected. The majority of the population was Christian. All Christian-majority countries were placed in medium to very high human development rankings. Buddhist-majority countries had high to very high human development. The Jewish majority population living in Israel was also had very high human development. While most of the low human development countries had the Islamic majority population.
Editorial
Authors: Zaniboni Hâmara Milaneze de Souza , Pina Ticiana Petean
Published: October 2023

É com grande satisfação que apresentamos a primeira edição da Revista Puxirum: Abordagem Multidisciplinar em Ciências Agrárias. O nome "Puxirum" deriva do Tupi-Guarani e significa "reunião de indivíduos para atividades agrícolas" ou "mutirão". Essas raízes ancestrais refletem nossa missão de unir mentes e esforços para compartilhar conhecimento e promover o desenvolvimento e avanços na ciência brasileira. A Revista Puxirum é uma plataforma editorial científica dedicada à disseminação de informações técnicas e contribuições nas áreas das ciências agrárias, com ênfase nas disciplinas de Agronomia, Medicina Veterinária e Zootecnia, Recursos Pesqueiros, bem como Ciências de Alimentos. Nossa política editorial prioriza a publicação científica revisada por pares em acesso livre e gratuito, com o objetivo de tornar o conhecimento acessível a todos.
MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion
Authors: Zheng Shixing , Wang Xiaoxia , Matskova Liudmila , Zhou Xiaoying , Zhang Zhe , Kashuba Elena , Ernberg Ingemar , Aspenström Pontus
Published: October 2023

Loss of cell–cell adhesions is the indispensable first step for cancer cells to depart from the primary tumor mass to metastasize. Metastasis suppressor 1 (MTSS1) is frequently lost in metastatic tissues, correlating to advanced tumor stages and poor prognosis across a variety of cancers. Here we explore the anti-metastatic mechanisms of MTSS1, which have not been well understood. We found that MTSS1 is downregulated in NPC tissues. Lower levels of MTSS1 expression correlate to worse prognosis. We show that MTSS1 suppresses NPC cell migration and invasion in vitro through cytoskeletal remodeling at cell–cell borders and assembly of E-cadherin/β-catenin/F-actin in adherens junctions. The I-BAR domain of MTSS1 was both necessary and sufficient to restore this formation of E-cadherin/β-catenin/F-actin–mediated cell adherens junctions.
Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes
Authors: Li Qi , Li Xiao , Kan Shuo , Zhu Ting-Jun , Li Chang , Du Xin-Yue , Wang Xin , Yan Hui-Bo , Wu Chen-Yun , Chen Guang-Jie , Qian Men-Bao , Yan Min , Wang Zhao-Jun
Published: October 2023

Introduction

Clonorchis sinensis infection results in various complications in the liver and biliary systems and is a neglected tropical disease in Eastern Asia. In this study, we report that C. sinensis calcium-binding protein Cs16 activates host immune cells and induces immunopathology in liver.

Methods

Immunohistochemistry was used to detect the localization of Cs16 in C. sinensis adult worms. ELISA was used to detect the serum levels of anti-Cs16 IgG antibody in infected humans and mice. Bile duct injection model was used to figure out the role of Cs16 in vivo. RT-qPCR and ELISA were used to detect the cytokine production from Cs16-treated BMMs in vitro. Seahorse assay was used to detect the metabolic pathway of Cs16-treated BMMs in vitro.

Result

Cs16 localizes in the tegument and gut of C. sinensis. Humans and mice with C. sinensis infection exhibited increased levels of anti-Cs16-specific antibody. Using the bile duct injection technique, we found that Cs16 induced obvious inflammation and hepatic necrosis in vivo. Cs16 treatment caused the upregulation of inflammatory cytokines in innate immune cells. Moreover, Cs16-treated monocytes relied more on the glycolytic metabolic pathway.

Discussion

Our findings suggest that Cs16 is a potential pathogenic factor derived from C. sinensis adult worm. By reprogramming the metabolic pathway of innate immune cells, Cs16 triggers pro-inflammatory responses in the liver, and therefore, Cs16 is a potential target for the prevention and treatment of clonorchiasis.
Unifying complexity science and machine learning
Authors: Krakauer David C.
Published: October 2023

Complexity science and machine learning are two complementary approaches to discovering and encoding regularities in irreducibly high dimensional phenomena. Whereas complexity science represents a coarse-grained paradigm of understanding, machine learning is a fine-grained paradigm of prediction. Both approaches seek to solve the “Wigner-Reversal” or the unreasonable ineffectiveness of mathematics in the adaptive domain where broken symmetries and broken ergodicity dominate. In order to integrate these paradigms I introduce the idea of “Meta-Ockham” which 1) moves minimality from the description of a model for a phenomenon to a description of a process for generating a model and 2) describes low dimensional features–schema–in these models. Reinforcement learning and natural selection are both parsimonious in this revised sense of minimal processes that parameterize arbitrarily high-dimensional inductive models containing latent, low-dimensional, regularities. I describe these models as “super-Humean” and discuss the scientic value of analyzing their latent dimensions as encoding functional schema.
Electrocardiographic characteristics associated with late gadolinium enhancement and prognostic value in patients with dilated cardiomyopathy
Authors: Chayanopparat Punyanuch , Boonyasirinant Thananya , Prapan Natthaporn , Phoopattana Supamongkol , Kaolawanich Yodying
Published: October 2023

Background

Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging has emerged as an important tool for assessment of patients with dilated cardiomyopathy (DCM). Electrocardiography (ECG) is an accessible, reproducible, low-cost diagnostic and prognostic tool. This study aimed to investigate the ECG characteristics associated with LGE, as well as to assess the prognostic significance of ECG in patients with DCM.

Methods

Consecutive patients diagnosed with DCM by CMR [left ventricular ejection fraction (LVEF) < 50%] between 2011 and 2020 were included. Multivariable analysis was conducted to evaluate ECG predictors associated with LGE. Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic performance of ECG in combination of clinical data and LVEF for LGE. Two composite outcomes were also assessed among patients with and without ECG predictors: (1) sudden cardiac death (SCD), sustained ventricular arrhythmia, or appropriate implantable cardioverter-defibrillator (ICD) therapy, and (2) all-cause death or hospitalization for heart failure.

Results

A total of 422 patients, with a mean age of 59.5 ± 16.3 years (58.3% male), were included. LGE was present in 169 (40%) of the patients. Multivariable analysis identified lateral inverted T-waves, intraventricular conduction delay, low voltage, and fragmented QRS as independent predictors of LGE. ROC analysis showed a significant increase in the area under the curve (AUC) when ECG predictors of the four aforementioned characteristics were added to the clinical-LVEF model (AUC 0.66, 95% CI 0.59–0.71 vs. 0.72, 95% CI 0.67–0.78, p = 0.003). During a median follow-up of 2.7 years (IQR 0.8, 5.2), 16 events of SCD, sustained ventricular arrhythmia, or appropriate ICD therapy, and 70 events of all-cause death or hospitalization for heart failure occurred. ECG predictors were independently associated with SCD, sustained ventricular arrhythmia, or appropriate ICD therapy (HR 4.84, 95% CI 1.34–17.40, p = 0.01). However, ECG predictors were not associated with all-cause death or hospitalization for heart failure (HR 1.22, 95% CI 0.76–1.96, p = 0.39).

Conclusion

In patients with DCM, lateral inverted T-waves, intraventricular conduction delay, low voltage, and fragmented QRS were independently associated with LGE. Additionally, these ECG predictors had prognostic value for predicting SCD, sustained ventricular arrhythmia, or appropriate ICD therapy, assisting clinicians in stratifying SCD risk and identifying primary prevention ICD implantation candidates.
Special challenge interprofessional education – how should lecturers be trained?
Authors: Schlicker Andrea , Nitsche Julia , Ehlers Jan
Published: October 2023

To enable interprofessional collaboration in practice, it is important to practice interprofessional action during education. Teachers in interprofessional education (IPE) in Germany are insufficiently prepared for joint teaching and often lack pedagogical-didactical training. Teachers who have been who have been used to working uniprofessionally up to now are expected to be able to teach competently across professions. This overlooks the fact that the admission requirements for teaching at the various institutions such as technical colleges, universities of applied sciences and universities are different. In addition, interprofessional teaching is characterized by a special feature: it should be carried out in team teaching. This poses the challenge for the teachers not only to prepare for the teaching in terms of content, but also to get involved with another teaching person. This study asks what interprofessional faculty need to feel well prepared to teach together and focuses on three professions: human medicine, nursing, and physiotherapy. For this purpose, 15 experts were interviewed, five from each of the three professions. The interview material was analyzed according to the structuring qualitative content analysis by Kuckartz, where categories were created to answer the research question. As a result, the analysis showed that three levels are important for the interviewees: the personal prerequisites that contribute to the success of IPE as well as good preparation on a structural and content-related level. Based on this, a concept for further education for interprofessional teachers will be developed.
Intra-annual dynamic of opposite and compression wood formation of Pinus massoniana Lamb. in humid subtropical China
Authors: Wang Chunsong , Zheng Zhuangpeng , Zhou Feifei , Liu Xinsheng , Fonti Patrick , Gao Jiani , Fang Keyan
Published: October 2023

Radial growth of trees can result in opposite wood (OW) and compression wood (CW) due to the varying impact of stem mechanical stress, such as that caused by gravity or wind. Previous research has identified higher xylem production in CW compared to OW. Yet, it remains unclear whether the difference in the number of xylem cells between OW and CW results from differences in growth rate or the duration of xylem cells. In this study, we collected wood microcores on a weekly basis from March 2019 to January 2020 in Pinus massoniana Lamb. located on a steep slope. Our objective was to compare the dynamic of cambial activity and resulting cellular anatomical parameters between OW and CW in a humid subtropical environment. Our results showed that the xylem phenology of OW and CW was generally consistent with the xylem cell division process beginning in early March and ceasing in November. The last latewood cell completed its differentiation at the end of December. The response of wood formation dynamics to climate was consistent in both OW and CW. Moreover, both wood types exhibited a limited development of the enlargement phase due to the heat and drought during the summer. The rate of cell division was responsible for 90.7% of the variability in the number of xylem cells. The CW xylem obtained a larger number of cells by increasing the rate of cell division and displayed thinner earlywood cells with larger lumens than OW cells. Our findings showed that the xylem of conifer species responds to mechanical stress by accelerating the cell division rate. As a result, we suggest calculating the ratio between OW and CW widths to reconstruct wind stress changes rather than calculating the residuals used in the current study.
The Eco Ladder for energy management: a literature review of economic driving and energy management
Authors: Nævestad Tor-Olav , Hesjevoll Ingeborg Storesund
Published: October 2023

Transport accounts for nearly 25% of man-made emissions of greenhouse gases, and goods transport by road accounts for 45% of the total energy consumption in transport. Measures within goods transport will therefore be a good starting point for reducing greenhouse gas emissions. Existing research shows that trucking companies’ measures to facilitate an economic driving style can achieve between 5% and 10% reduction in fuel consumption. They can probably reduce their energy consumption even more, by focusing on factors additional to driving style. However, existing recipes for such measures (e.g., ISO: 50001) seem to be relatively complicated, resource-intensive, and to a small extent adapted to transport. Previous research shows low implementation of such management systems in trucking companies, because most of them are small (<5 employees), and probably have few resources when it comes to economy, time and expertise. The aim of the study, is therefore to develop a research-based model of how trucking companies can work with economic driving and energy management at the organizational level. The model is based on a systematic review of measures for economic driving and energy management in trucking companies. The model is referred to as the Eco Ladder for energy management, and describes an approach with gradual introduction of specific measures. Companies must start with the measures that are assumed to have the greatest effect, and which are easiest to implement, before moving on to the next level. Based on existing research, we discuss expected effects for economy, emissions, traffic safety and working environment.
Case report: ADULT syndrome: a rare case of congenital lacrimal duct abnormality
Authors: Zhou Jichao , Wang Yuchen , Zhang Yinghong , You Debo , Wang Yi
Published: October 2023

Acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome is a rare autosomal dominant inherited disease caused due to mutations in the TP63 gene. More commonly, mutations in the TP63 gene result in ectodermal dysplasia and/or orofacial cleft. ADULT syndrome is a type of ectoderm-related tissue dysplasia. This case report describes a patient with chronic tearing, congenital atresia, and obstruction of the lacrimal ducts, which are the main clinical manifestations of ADULT syndrome. This patient also presented with some clinical manifestations that were different from those of ADULT syndrome, namely, mild eyelid fusion and abnormal development of the fifth finger (a stiff fifth finger with camptodactyly that was shortened in length). The gene mutation in this patient was also at a site different from those usually reported in the literature. In this patient, c.518G > T resulted in p. G173V (accession number: NM_003722; exon4). We performed successful dacryocystorhinostomy and artificial lacrimal duct implantation. As shown above, we discussed the clinical characteristics and genetics of the disease in detail. In sharing this case, we aim to contribute to the current understanding of the genes and clinical manifestations of ADULT syndrome and to assist clinicians in the clinical diagnosis of TP63 mutation-related diseases.
Sintilimab-induced inflammatory myopathy in a patient with esophageal cancer: a case report
Authors: Hong Guo , Zhao Haina , Yin Yuxuan , Shen Hailin , Zeng Zhaohao , Yang Jianwei , Zhang Lili
Published: October 2023

The use of immune checkpoint inhibitors (ICIs) has shown remarkable efficacy in the treatment of various malignancies, significantly reshaping cancer treatment. However, as a result of the widespread use of ICIs, several immune-related adverse events (iRAEs) have emerged, some of which can be rare and potentially fatal. In this paper, we reported the earliest case of Sintilimab used in the treatment of esophageal cancer with severe inflammatory myopathy (involving the cardiac, respiratory, and skeletal muscles)in China. This patient was an elderly female who presented to our institution with progressive limb weakness and ptosis. Prior to the onset of symptoms, the patient had undergone a radical esophagectomy for esophageal cancer, experienced several cycles of of radiotherapy and chemotherapy, as well as two doses of Sintilimab treatment. Shortly after initiating immunotherapy, the patient developed symptoms including bilateral ptosis, limb weakness, and difficulty swallowing and breathing. The levels of creatine kinase and troponin I in the patient’s blood were significantly elevated, and positive results were observed for anti-skeletal and anti-cardiac muscle antibodies, indicating that the patient might be developing ICIs-related inflammatory myopathy. Fortunately, the patient responded well to treatment including corticosteroids, plasmapheresis, intravenous immunoglobulin, and other supportive therapies. Here, we discuss the incidence, mechanisms, and management strategies of fatal iRAEs. Early detection and timely intervention may be critical in reducing the incidence and mortality rates of iRAEs and improving patient outcomes.
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection
Authors: Lécuyer Déborah , Nardacci Roberta , Tannous Désirée , Gutierrez-Mateyron Emie , Deva Nathan Aurélia , Subra Frédéric , Di Primio Cristina , Quaranta Paola , Petit Vanessa , Richetta Clémence , Mostefa-Kara Ali , Del Nonno Franca , Falasca Laura , Marlin Romain , Maisonnasse Pauline , Delahousse Julia , Pascaud Juliette , Deprez Eric , Naigeon Marie , Chaput Nathalie , Paci Angelo , Saada Véronique , Ghez David , Mariette Xavier , Costa Mario , Pistello Mauro , Allouch Awatef , Delelis Olivier , Piacentini Mauro , Le Grand Roger , Perfettini Jean-Luc
Published: October 2023

Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here, we report that the purinergic receptor P2X7 and NLRP3 inflammasome are cellular host factors required for SARS-CoV-2 infection. Lung autopsies from patients with severe coronavirus disease 2019 (COVID-19) reveal that NLRP3 expression is increased in host cellular targets of SARS-CoV-2 including alveolar macrophages, type II pneumocytes and syncytia arising from the fusion of infected macrophages, thus suggesting a potential role of NLRP3 and associated signaling pathways to both inflammation and viral replication. In vitro studies demonstrate that NLRP3-dependent inflammasome activation is detected upon macrophage abortive infection. More importantly, a weak activation of NLRP3 inflammasome is also detected during the early steps of SARS-CoV-2 infection of epithelial cells and promotes the viral replication in these cells. Interestingly, the purinergic receptor P2X7, which is known to control NLRP3 inflammasome activation, also favors the replication of D614G and alpha SARS-CoV-2 variants. Altogether, our results reveal an unexpected relationship between the purinergic receptor P2X7, the NLRP3 inflammasome and the permissiveness to SARS-CoV-2 infection that offers novel opportunities for COVID-19 treatment.