bluuebunny/crossref_metadata_2025 huggingface dataset:
Antimicrobial resistance of clinical bacterial isolates according to the WHO’s AWaRe and the ECDC-MDR classifications: the pattern in Ghana’s Bono East Region
Authors: Walana Williams , Vicar Ezekiel Kofi , Kuugbee Eugene Dogkotenge , Sakida Francis , Yabasin Iddrisu Baba , Faakuu Eric , Amfoabegyi Solomon , Ziem Juventus Benogle
Published: December 2023

Introduction

Antimicrobial resistance (AMR) remains a significant health challenge globally and nations have the responsibility to maintain a constant surveillance of AMR, particularly for the emergence of multidrug-resistant (MDR) isolates to existing antibiotics. Against this backdrop, we applied the WHO’s AWaRe (ACCESS, WATCH, and RESERVE) antibiotics classification and the European Centre for Disease Prevention and Control (ECDC)’s multidrug resistance definition for AMR isolates from clinical specimens.

Method

This study reviewed bacterial culture and antibiotic sensitivity test outcomes. These results were then grouped according to the AWaRe and ECDC-MDR classifications.

Results

In all, the culture and sensitivity results of the 3,178 clinical specimens were investigated, of which 59.5% were from female patients. The pathogens were isolated from 1,187 specimens (37.4%). The WHO’s ACCESS antibiotics, tetracycline, showed a relatively high level of insusceptibility, particularly among Gram-positive (GP) isolates (ranging from 66.7% to 76.7%), along with augmentin (ranging from 44.7% to 81.3%) and cloxacillin (ranging from 50.0% to 78.1%). However, the Gram-negative (GN) isolates showed a relatively high level of susceptibility to amikacin, augmentin, and nitrofurantoin. The WHO’s WATCH antibiotics, cefuroxime, ceftriaxone, cefotaxime, and ciprofloxacin showed a relatively high level of non-responsiveness among the GN isolates, particularly Proteus (ranging from 31.4% to 78.4%), Pseudomonas (ranging from 21.4% to 96.4%), and Enterobacter (ranging from 62.5% to 100%) spp. Among the WHO’s RESERVE antibiotics, resistance to ceftazidime was commonly associated with the GN coliform isolates: Eschericha coli, Klebsiella, and Citrobacter spp. Insusceptibility to meropenem was frequently observed in Staphylococcus spp., E. coli, coliforms, and Proteus spp. Out of the 1,187 isolates, 15.5% (184) were GAT (gentamycin, ampicillin, and tetracycline) MDR, of which 61% (112/184) were from specimens of female patients. The most predominant GAT-MDR isolates were Staphylococcus spp., E. coli, coliforms, and Klebsiella spp.

Conclusion

In conclusion, the study revealed a relatively high level and diverse range of AMR. However, MDR in accordance with the ECDC definition was relatively low. There is, therefore, a need to have further research on AMR to inform national criteria for MDR in Ghana.
Safer not to know? Shaping liability law and policy to incentivize adoption of predictive AI technologies in the food system
Authors: Alexander Carrie S. , Smith Aaron , Ivanek Renata
Published: December 2023

Governments, researchers, and developers emphasize creating “trustworthy AI,” defined as AI that prevents bias, ensures data privacy, and generates reliable results that perform as expected. However, in some cases problems arise not when AI is not trustworthy, technologically, but when it is. This article focuses on such problems in the food system. AI technologies facilitate the generation of masses of data that may illuminate existing food-safety and employee-safety risks. These systems may collect incidental data that could be used, or may be designed specifically, to assess and manage risks. The predictions and knowledge generated by these data and technologies may increase company liability and expense, and discourage adoption of these predictive technologies. Such problems may extend beyond the food system to other industries. Based on interviews and literature, this article discusses vulnerabilities to liability and obstacles to technology adoption that arise, arguing that “trustworthy AI” cannot be achieved through technology alone, but requires social, cultural, political, as well as technical cooperation. Implications for law and further research are also discussed.
Innate immune modulation in transplantation: mechanisms, challenges, and opportunities
Authors: Praska Corinne E. , Tamburrini Riccardo , Danobeitia Juan Sebastian
Published: December 2023

Organ transplantation is characterized by a sequence of steps that involve operative trauma, organ preservation, and ischemia-reperfusion injury in the transplant recipient. During this process, the release of damage-associated molecular patterns (DAMPs) promotes the activation of innate immune cells via engagement of the toll-like receptor (TLR) system, the complement system, and coagulation cascade. Different classes of effector responses are then carried out by specialized populations of macrophages, dendritic cells, and T and B lymphocytes; these play a central role in the orchestration and regulation of the inflammatory response and modulation of the ensuing adaptive immune response to transplant allografts. Organ function and rejection of human allografts have traditionally been studied through the lens of adaptive immunity; however, an increasing body of work has provided a more comprehensive picture of the pivotal role of innate regulation of adaptive immune responses in transplant and the potential therapeutic implications. Herein we review literature that examines the repercussions of inflammatory injury to transplantable organs. We highlight novel concepts in the pathophysiology and mechanisms involved in innate control of adaptive immunity and rejection. Furthermore, we discuss existing evidence on novel therapies aimed at innate immunomodulation and how this could be harnessed in the transplant setting.
Preoperative anxiety management in children. Benefits of humanoid robots: an experimental study
Authors: Franconi Ilaria , Faragalli Andrea , Palego Giulia , Canonici Samuele , Gatti Ludovica , Simonini Alessandro , Bindi Edoardo , Cobellis Giovanni , Carle Flavia
Published: December 2023

Objective

The purpose of this study was to determine whether the use of a humanoid robot (Estrabot) could reduce preoperative anxiety levels in children.

Methods

An experimental study was conducted at Azienda Ospedaliero Universitaria delle Marche Hospital, involving the Pediatric Surgery ward and the Operating Room (OR). Patients aged between 2 and 14 years who underwent minor surgery were included. The Instruments used were the Children's Emotional Manifestation Scale to evaluate anxiety levels, and Estrabot, a humanoid robot that interacts with people. Medical records between April and May 2023 were analyzed and the data was anonymous. The level of anxiety is extrapolated in Pediatric Surgery during the administration of oral pre-medication, and in the Operating Room, during the induction of anesthesia. Patients were divided into an intervention group treated with Estrabot, and a control group without a robot.

Results

The population consists of 60 patients (86.7% male) with a median (IQR) age of 6 (4–8) years. The median (IQR) anxiety score during premedication was 7 (5–11), while the median (IQR) anxiety score during anesthesia was 6 (5–10). A significantly lower level of anxiety was reported in the Estrabot group. Patients in the Estrabot group had significantly lower anxiety levels in different age groups.

Conclusion

A humanoid robot can reduce preoperative anxiety levels in children during premedication and the induction of anesthesia.
The use of machine learning to predict somatic cell count status in dairy cows post-calving
Authors: Thompson Jake S. , Green Martin J. , Hyde Robert , Bradley Andrew J. , O’Grady Luke
Published: December 2023

Udder health remains a priority for the global dairy industry to reduce pain, economic losses, and antibiotic usage. The dry period is a critical time for the prevention of new intra-mammary infections and it provides a point for curing existing intra-mammary infections. Given the wealth of udder health data commonly generated through routine milk recording and the importance of udder health to the productivity and longevity of individual cows, an opportunity exists to extract greater value from cow-level data to undertake risk-based decision-making. The aim of this research was to construct a machine learning model, using routinely collected farm data, to make probabilistic predictions at drying off for an individual cow’s risk of a raised somatic cell count (hence intra-mammary infection) post-calving. Anonymized data were obtained as a large convenience sample from 108 UK dairy herds that undertook regular milk recording. The outcome measure evaluated was the presence of a raised somatic cell count in the 30 days post-calving in this observational study. Using a 56-farm training dataset, machine learning analysis was performed using the extreme gradient boosting decision tree algorithm, XGBoost. External validation was undertaken on a separate 28-farm test dataset. Statistical assessment to evaluate model performance using the external dataset returned calibration plots, a Scaled Brier Score of 0.095, and a Mean Absolute Calibration Error of 0.009. Test dataset model calibration performance indicated that the probability of a raised somatic cell count post-calving was well differentiated across probabilities to allow an end user to apply group-level risk decisions. Herd-level new intra-mammary infection rate during the dry period was a key driver of the probability that a cow had a raised SCC post-calving, highlighting the importance of optimizing environmental hygiene conditions. In conclusion, this research has determined that probabilistic classification of the risk of a raised SCC in the 30 days post-calving is achievable with a high degree of certainty, using routinely collected data. These predicted probabilities provide the opportunity for farmers to undertake risk decision-making by grouping cows based on their probabilities and optimizing management strategies for individual cows immediately after calving, according to their likelihood of intra-mammary infection.
Beak fracture associated with leiomyosarcoma in a budgerigar (Melopsittacus undulatus): a case report and literature review
Authors: Rasche Brittany L. , Barrantes Murillo Daniel Felipe , Negrão Watanabe Tatiane Terumi
Published: December 2023

A 2-year-old male budgerigar (Melopsittacus undulatus) died after a 1-day history of fracture of the rostral rhinotheca with pale mucous membranes, dyspnea, dull mentation, and ataxia. Histopathology revealed an infiltrative neoplasm composed of interweaving streams of spindle cells effacing the dermis and bone of the rostral upper beak as well as a ganglion and two cranial nerves. No visceral metastasis was observed. Neoplastic cells exhibited strong cytoplasmic immunolabeling for alpha-smooth muscle actin (α-SMA) and lacked immunolabeling for S100, Melan-A, PNL2, and cytokeratin AE1/AE3. These findings were consistent with a locally invasive leiomyosarcoma Leiomyosarcomas arise from the smooth muscle and are locally invasive with rare metastases. In birds, leiomyosarcomas are mostly reported to arise from the spleen, gastrointestinal, and reproductive tracts. In the case report herein, we describe the histological and immunohistochemical features of a primary beak leiomyosarcoma in a budgerigar associated with a fracture located at the rostral rhinotheca. Leiomyosarcoma arising from the beak has not been described in the literature.
Active Control of the Reflection Coefficient of an Underwater Surface
Authors: Timmermann Johannes , Hövelmann Norbert , Sachau Delf
Published: December 2023

From a strategic point of view, it is essential to protect underwater vehicles from being detected by opponents. Modern mono- or bistatic sonar systems are capable of precisely determining the position of a watercraft. In order to triangulate the positions of watercrafts, the sonar sends out acoustic signals that are reflected by the vehicles’ surfaces. These deflected sound waves are subsequently detected and evaluated. How well an object can be detected using a sonar can be measured according to the target strength. Through their shape, construction and choice of materials, modern underwater vehicles are optimized in relation to minimizing their radiated and reflected sound waves; in this way, their target strength is minimized. These passive measures are particularly effective in the medium- and high-frequency range down to 1500 Hz. To effectively reduce reflections at lower frequencies, an active system is developed in this study and evaluated in a laboratory test with a water-filled impedance tube. The incident sound waves were measured in front of an active surface and then processed using an adaptive control system based on an FPGA platform. The system operates with a very thin piezoceramic applied to the surface in order to minimize the reflections of the sound waves. The laboratory tests showed the high effectiveness of the system under the influence of sonar-like signals.
Approaches to Laparoscopic Training in Veterinary Medicine: A Review of Personalized Simulators
Authors: Dejescu Cosmina Andreea , Bel Lucia V. , Melega Iulia , Muresan Stefana Maria Cristina , Oana Liviu Ioan
Published: December 2023

Veterinary minimally invasive surgery (MIS) has experienced notable growth in recent years, yet the availability of specialized training tools remains limited and not readily accessible to practitioners worldwide. While borrowing simulators from human medicine practices suffices for acquiring fundamental laparoscopic skills, it proves inadequate when addressing procedure-specific nuances. Veterinary professionals are now taking steps to create simulators tailored to their patients, although the validation process can be time-consuming. Consequently, the availability of advanced laparoscopic simulators for veterinary training remains scarce. The present study aims to highlight custom-made simulators. A comprehensive search across five databases was conducted to uncover the simulators documented from 2010 to 2022. A total of five simulators emerged from this search, with four grounded in a canine model and only one in an equine model. These models underwent validation and were found to be effective in training surgeons for their designated tasks. The findings underscore a limited array of simulators, predominantly catering to two species (horses and dogs). Considering these findings, it is evident that further research is imperative to create laparoscopic simulators capable of facilitating advanced veterinary training. This would enable the continued evolution of surgical techniques across diverse species, including ruminants, small mammals, and non-mammalian animals.
Microencapsulated Sodium Butyrate Alleviates Immune Injury and Intestinal Problems Caused by Clostridium Perfringens through Gut Microbiota
Authors: Yang Ting , Sun Yaowei , Dai Zhenglie , Liu Jinsong , Xiao Shiping , Liu Yulan , Wang Xiuxi , Yang Shenglan , Zhang Ruiqiang , Yang Caimei , Dai Bing
Published: December 2023

Microencapsulated sodium butyrate (MS-SB) is an effective sodium butyrate additive which can reduce the release of sodium butyrate (SB) in the fore gastrointestinal tract. In this study, we assess the protective effects and mechanisms of MS-SB in Clostridium perfringens (C. perfringens)-challenged broilers. Broiler chickens were pre-treated with SB or MS-SB for 56 days and then challenged with C. perfringens three times. Our results indicate that the addition of MS-SB or SB before C. perfringens infection significantly decreased the thymus index (p < 0.05). Serum IgA, IgY, and IgM concentrations were significantly increased (p < 0.05), while pro-inflammatory IL-1β, IL-6, and TNF-α were significantly decreased (p < 0.05) under MS-SB or SB supplementation. Compared with SB, MS-SB presented a stronger performance, with higher IgA content, as well as a lower IL-1β level when normal or C. perfringens-challenged. While C. perfringens challenge significantly decreased the villus height (p < 0.05), MS-SB or SB administration significantly increased the villus height and villus height/crypt depth (V/C ratio) (p < 0.05). Varying degrees of SB or MS-SB increased the concentrations of volatile fatty acids (VFAs) during C. perfringens challenge, where MS-SB presented a stronger performance, as evidenced by the higher content of isovaleric acid and valeric acid. Microbial analysis demonstrated that both SB or MS-SB addition and C. perfringens infection increase variation in the microbiota community. The results also indicate that the proportions of Bacteroides, Faecalibacterium, Clostridia, Ruminococcaceae, Alistipes, and Clostridia were significantly higher in the MS-SB addition group while, at same time, C. perfringens infection increased the abundance of Bacteroides and Alistipes. In summary, dietary supplementation with SB or MS-SB improves the immune status and morphology of intestinal villi, increases the production of VFAs, and modulates cecal microbiota in chickens challenged with C. perfringens. Moreover, MS-SB was more effective than SB with the same supplemental amount.
A Comparative Analysis of Sparisoma cretense in Island Environments: Unraveling Metal Accumulation Differences in the Canary Islands (Spain, NW African Waters)
Authors: Lozano-Bilbao Enrique , Jurado-Ruzafa Alba , Lorenzo José M. , González José A. , Hardisson Arturo , González-Weller Dailos , Paz Soraya , Rubio Carmen , Gutiérrez Ángel J.
Published: December 2023

This study investigates the impact of varying environmental conditions on the metal composition within the tissues of Sparisoma cretense, contributing to the understanding necessary to offer scientifically sound advice regarding the health status of this species. This knowledge extends beyond fishery production, encompassing implications for food security. The data span the years 2022 and 2023, encompassing both cold and warm climatic seasons. The concentrations of various metals, such as Al, Zn, Cd, Pb, Fe, and Cu, exhibited noteworthy variations across the islands, with significant increases recorded in 2023, particularly during the warm season. The intricate interplay between multiple factors shaped the availability of the analyzed elements in S. cretense. Factors such as rising temperatures during the warm season increased biological activity in marine ecosystems, seasonal fluctuations in weather conditions, water quality, and anthropogenic influences, all contributing to the observed variations in metal concentrations. Additionally, the geological composition of each island and the patterns of marine currents and sediment transport play pivotal roles in these differences. Comprehensive scientific research, monitoring, and environmental surveillance are essential for a holistic understanding of this variability and providing valuable insights for the conservation and management of marine ecosystems in the Canary archipelago.
The Occurrence of Freshwater Fish-Borne Zoonotic Helminths in Italy and Neighbouring Countries: A Systematic Review
Authors: Menconi Vasco , Lazzaro Elena , Bertola Michela , Guardone Lisa , Mazzucato Matteo , Prearo Marino , Bilska-Zajac Ewa , Cortinovis Luana , Manfrin Amedeo , Arcangeli Giuseppe , Angeloni Giorgia
Published: December 2023

In recent years, the consumption of fish products has surged in European countries, being an essential part of a healthy diet. Despite representing a small part of EU production, freshwater fisheries hold considerable significance for lake-dwelling populations and tourists seeking traditional dishes. This increased fish consumption has brought to light potential health risks associated with fish-borne zoonotic helminths (FBZHs), now acknowledged as global food-borne parasites. Fish-borne zoonotic helminths belong to various taxonomic groups, including nematodes (Anisakidae), trematodes (Opisthorchiidae and Heterophyidae), and cestodes (Diphyllobothriidae). More than 50 species of FBZH are known to cause human infections, derived from eating raw or undercooked aquatic foods containing viable parasites. Despite increased attention, FBZHs remain relatively neglected compared to other food-borne pathogens due to factors like chronic disease progression and under-diagnosis. This systematic review concentrates on the prevalence of six freshwater FBZHs (Clinostomum complanatum, Contracaecum rudolphii, Dibothriocephalus latus, Eustrongylides excisus, Opisthorchis felineus, and Pseudamphistomum truncatum) in Italy and neighbouring countries. The study explores the expansion of these parasites, analysing their biological and epidemiological aspects, and the factors that influence their proliferation, such as the increased cormorant population and the lake eutrophication phenomena. In summary, this research highlights the necessity for further research, the development of spatial databases, and the establishment of a unified European policy to effectively manage these multifaceted health concerns. It strongly advocates adopting a One-Health approach to address the growing incidence of parasitic zoonoses within the context of food safety in EU countries.
Use of Low-Cost Sensors for Environmental Health Surveillance: Wildfire-Related Particulate Matter Detection in Brasília, Brazil
Authors: Connerton Patrick , Nogueira Thiago , Kumar Prashant , Ribeiro Helena
Published: December 2023

Ambient air quality is the most important environmental factor affecting human health, estimated by the WHO to be responsible for 4.2 million deaths annually. Having timely estimates for air quality is critical for implementing public policies that can limit anthropogenic emissions, reduce human exposure and allow for preparation and interventions in the health sector. In Brazil, wildfires constitute an important source of particulate matter emission, particularly in the country’s northern and midwestern regions, areas that are under-served in terms of air quality monitoring infrastructure. In the absence of regulatory-grade monitoring networks, low-cost sensors offer a viable alternative for generating real-time, publicly available estimates of pollutant concentrations. Here, we examine data from two low-cost sensors deployed in Brasília, in the Federal District of Brazil, during the 2022 wildfire season and use NOAA’s HYSPLIT model to investigate the origin of a particulate matter peak detected by the sensors. There was high agreeability of the data from the two sensors, with the raw values showing that daily average PM2.5 concentrations reached peak values of 46 µg/m3 and 43 µg/m3 at the school and park sites, respectively. This study demonstrates the value of low-cost sensors and their possible application in real-time scenarios for environmental health surveillance purposes.
Transforming Drug Design: Innovations in Computer-Aided Discovery for Biosimilar Agents
Authors: Askari Shadi , Ghofrani Alireza , Taherdoost Hamed
Published: December 2023

In pharmaceutical research and development, pursuing novel therapeutics and optimizing existing drugs have been revolutionized by the fusion of cutting-edge technologies and computational methodologies. Over the past few decades, the field of drug design has undergone a remarkable transformation, catalyzed by the rapid advancement of computer-aided discovery techniques and the emergence of biosimilar agents. This dynamic interplay between scientific innovation and technological prowess has expedited the drug discovery process and paved the way for more targeted, effective, and personalized treatment approaches. This review investigates the transformative computer-aided discovery techniques for biosimilar agents in reshaping drug design. It examines how computational methods expedite drug candidate identification and explores the rise of cost-effective biosimilars as alternatives to biologics. Through this analysis, this study highlights the potential of these innovations to enhance the efficiency and accessibility of pharmaceutical development. It represents a pioneering effort to examine how computer-aided discovery is revolutionizing biosimilar agent development, exploring its applications, challenges, and prospects.
The Defined TLR3 Agonist, Nexavant, Exhibits Anti-Cancer Efficacy and Potentiates Anti-PD-1 Antibody Therapy by Enhancing Immune Cell Infiltration
Authors: Lee Seung-Hwan , Choi Young-Ho , Kang Soon Myung , Lee Min-Gyu , Debin Arnaud , Perouzel Eric , Hong Seung-Beom , Kim Dong-Ho
Published: December 2023

Nexavant was reported as an alternative to the TLR3 agonist of Poly(I:C) and its derivatives. The physicochemical properties, signaling pathways, anti-cancer effects, and mechanisms of Nexavant were investigated. The distinctive characteristics of Nexavant compared to that of Poly(I:C) were demonstrated by precise quantification, enhanced thermostability, and increased resistance to RNase A. Unlike Poly(I:C), which activates TLR3, RIG-I, and MDA5, Nexavant stimulates signaling through TLR3 and RIG-I but not through MDA5. Compared to Poly(I:C), an intratumoral Nexavant treatment led to a unique immune response, immune cell infiltration, and suppression of tumor growth in various animal cancer models. Nexavant therapy outperformed anti-PD-1 antibody treatment in all the tested models and showed a synergistic effect in combinational therapy, especially in well-defined cold tumor models. The effect was similar to that of nivolumab in a humanized mouse model. Intranasal instillation of Nexavant led to the recruitment of immune cells (NK, CD4+ T, and CD8+ T) to the lungs, suppressing lung metastasis and improving animal survival. Our study highlighted Nexavant’s defined nature for clinical use and unique signaling pathways and its potential as a standalone anti-cancer agent or in combination with anti-PD-1 antibodies.
Utilising Pancreatic Exocrine Insufficiency in the Detection of Resectable Pancreatic Ductal Adenocarcinoma
Authors: McDonnell Declan , Afolabi Paul R. , Wilding Sam , Griffiths Gareth O. , Swann Jonathan R. , Byrne Christopher D. , Hamady Zaed Z.
Published: December 2023

Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed late, leading to a high mortality rate. Early detection facilitates better treatment options. The aim of this UK-based case–control study was to determine whether two validated tests for pancreatic exocrine insufficiency (PEI), namely, the 13C-mixed triglyceride breath test (13C-MTGBT) and a faecal elastase (FE-1) test, can discriminate between patients with resectable PDAC versus healthy volunteers (HVs) along with a comparison group with chronic pancreatitis (CP). Discrimination between disease states and HVs was tested with receiver operator characteristic (ROC) curves. In total, 59 participants (23 PDAC (16 men), 24 HVs (13 men) and 12 CP (10 men)) were recruited, with a similar age in each population, and a combined median (IQR) age of 66 (57–71). The areas under the ROC curve for discriminating between PDAC and HVs were 0.83 (95% CI: 0.70–0.96) for the 13C-MTGBT, and 0.85 (95% CI: 0.75–0.95) for the FE-1 test. These were similar to CP vs. HV. In conclusion, PEI occurs in resectable PDAC to a similar extent as in CP; further large-scale, prospective studies using these tests in the primary care setting on high-risk groups are warranted.
Review of the Structural Performance of Beams and Beam–Column Joints with Openings
Authors: Galustanian Narek , El-Sisi Alaa , Amer Asmaa , Elshamy Eman , Hassan Hilal
Published: December 2023

The need for openings in RC structures has increased, but their presence significantly affects the performance and strength of the structures. While small openings can be managed with additional reinforcement, dealing with large openings in reinforced or pre-stressed concrete members is challenging due to the lack of technical information and specific guidelines. This research provides an up-to-date overview of RC beam–column joints that incorporate web openings and evaluates appropriate strengthening methods. The research discusses the classification of openings in RC beams, considering factors such as size and shape. Additionally, it examines the failure modes of RC beams in relation to flexural and shear behavior when web openings are present. The research also provides a comprehensive review of various strengthening techniques, outlining their advantages and disadvantages. In conclusion, larger openings in beams result in reduced strength, while increasing loads lead to higher deflection, strain, and cracking until failure. Openings are classified as small or large based on their impact on beam behavior. Multiple smaller openings are preferred over a single large opening when size becomes excessive. Optimal placement is in the middle of the section to ensure adequate concrete coverage for the chords. Sufficient concrete and depth are essential for ultimate compression during bending and effective shear reinforcement.
Advances in Quantum Computing
Authors: La Cour Brian
Published: December 2023

Advances in quantum computing have continued to accelerate over the course of this Special Issue’s publication [...]
Carving Nature at Its Joints: A Comparison of CEMI Field Theory with Integrated Information Theory and Global Workspace Theory
Authors: McFadden Johnjoe
Published: December 2023

The quest to comprehend the nature of consciousness has spurred the development of many theories that seek to explain its underlying mechanisms and account for its neural correlates. In this paper, I compare my own conscious electromagnetic information field (cemi field) theory with integrated information theory (IIT) and global workspace theory (GWT) for their ability to ‘carve nature at its joints’ in the sense of predicting the entities, structures, states and dynamics that are conventionally recognized as being conscious or nonconscious. I go on to argue that, though the cemi field theory shares features of both integrated information theory and global workspace theory, it is more successful at carving nature at its conventionally accepted joints between conscious and nonconscious systems, and is thereby a more successful theory of consciousness.
Image Entropy-Based Interface Evaluation Method for Nuclear Power Plants
Authors: Tang Wenzhe , Chen Shanguang , Lin Yun , Xue Chengqi
Published: December 2023

The digital interface is crucial for nuclear plant operators, influencing their decision-making significantly. However, evaluations of these interfaces often overlook users’ decision-making performance; lack established standards, typically occurring after the design phase; and are unsuitable for large-scale assessments. Recognizing the vital role of interface information, this paper built on our previous research and proposed a method tailored for nuclear power plant interfaces, utilizing image entropy to evaluate the impact of information on decision-making. A comparative analysis with an experimental evaluation method empirically validated the effectiveness of the proposed method. This research offers a unique decision-making-centric method to interface evaluation, providing a standardized, adaptable framework for various design phases and enabling extensive and rapid evaluations.
Arrow Contraction and Expansion in Tropical Diagrams
Authors: Matveev Rostislav , Portegies Jacobus W.
Published: December 2023

Arrow contraction applied to a tropical diagram of probability spaces is a modification of the diagram, replacing one of the morphisms with an isomorphism while preserving other parts of the diagram. It is related to the rate regions introduced by Ahlswede and Körner. In a companion article, we use arrow contraction to derive information about the shape of the entropic cone. Arrow expansion is the inverse operation to the arrow contraction.
Knowledge of and Attitude towards First Aid Measures among Drivers in Sharjah
Authors: Mohamadiyeh Amjad , Said Mohammed Ra’a , Al-Dabbagh Banan , Saeed Rana , Al-Haboobi Furqan , AlJuwaied Maitha , Shorbagi Sarra , Hussein Amal
Published: December 2023

Injury is an important cause of mortality and morbidity. First aid is the immediate assistance provided to a suddenly injured or sick person until professional help arrives or that person has recovered. Many lives would be saved if proper first aid was provided early. In the Middle East, there are limited studies that explore knowledge and practices towards first aid needed during RTA. The aim of this study is to investigate the knowledge and attitude towards first aid among drivers in Sharjah. A cross-sectional study was conducted through a self-administered questionnaire written in Arabic and the English language. Participants were 18 years or older holding a driving license in the city of Sharjah. Paramedics and certified participants with a certification from authorized organizations were excluded. A non-proportional convenient sampling method was used. A total of 343 participants completed the questionnaires. The majority of the study participants were less than 40 years old, and (56.76%) were males. Most participants (94.2%) indicated that they know the term ‘First Aid’. However, (49.7%) of the participants knew the number to call for an ambulance, and (52.43%) of the participants indicated that the victim should be moved to the hospital without an ambulance. With regard to attitude, (34.86%) were not willing to provide first aid in the case of RTA. The main reason was lack of knowledge, followed by fear of legal consequences. Most participants (83.78%) were willing to participate in first aid classes to improve their knowledge and attitude. Most participants are aware of the basic terms of first aid; however, they are not willing to provide first aid in cases of RTA due to lack of knowledge and fear of legal consequences. Based on these findings, we recommend providing first aid classes to new drivers so that they can obtain certification.
The Relationship between Jealousy and Mate Retention Strategies in Romantic Relationships among Women during the COVID-19 Pandemic
Authors: Degiuli Paulina , Andreis Lea , Vučenović Dario
Published: December 2023

Jealousy and mate retention have received attention in research over the last few decades. Despite this, most of the research has examined male jealousy and male mate retention, emphasizing cost-inflicting behavior due to its role in relationships and domestic violence. The aim of this study was to investigate the relationship between jealousy and all mate retention strategies in romantic relationships among women during the COVID-19 pandemic. The sample consisted of 772 Croatian women aged 19 to 40 who were in a heterosexual relationship at the time. This study was conducted online, and the participants completed the Multidimensional Jealousy Scale and Mate Retention Inventory. The results showed that cognitive, emotional, and behavioral jealousy were positively correlated with all mate retention strategies, which indicates that a stronger experience of jealousy can be expected to result in more frequent use of all partner retention strategies. We also found that all three dimensions of jealousy and relationship length positively predicted both cost-inflicting and benefit-provisioning mate retention behavior, whereas age was a negative predictor of benefit-provisioning behavior only. The findings of this study suggest that, although jealousy can substantially explain interpersonally risky and damaging behavior in relationships, it can also explain affectionate and attentive behavior, to some extent.
Feasibility Analysis on Compression-Assisted Adsorption Chiller Using Chlorides for Underground Cold Transportation
Authors: Yu Meng , Jin Suke , Zhang Wenyun , Xia Guangyue , Liu Baoqin , Jiang Long
Published: December 2023

Thermal-driven refrigeration technologies, e.g., absorption- or adsorption-type, are gathering momentum since they can utilize low-grade heat from industrial, solar or geothermal energy. However, heat sources and end users are usually mismatched, which could lead to potential heat pollution and increased carbon emissions. Long-distance thermal energy transportation is good for district heating and cooling, which is of great significance if it can achieve a high energy-transportation density and low heat loss. In this paper, a compression-assisted chemisorption chiller driven by a low-temperature heat source for cold transportation is initially proposed, which aims to transport liquid ammonia with chemical potential and generate a cooling effect for end users. A feasibility analysis of the compression-assisted chemisorption chiller is preliminarily performed for 2 km cold transportation. The results show that the highest theoretical coefficient of performance and the energy efficiency of the compression-assisted adsorption chiller using a sodium bromide–ammonia working pair can reach 0.46 and 0.25, respectively, when the evaporation temperature is 20 °C. Among the three selected low-temperature salts, ammonium chloride–ammonia shows the best performance, which is up to about 40% higher than those of sodium bromide–ammonia and barium chloride–ammonia. It is demonstrated that compared with common absorption chillers, a compression-assisted adsorption system has a reasonable working efficiency to transport cold energy when the low- or ultralow-temperature heat source, e.g., lower than 60 °C, is required to be utilized.
FCH HVAC Honeycomb Ring Network—Transition from Traditional Power Supply Systems in Existing and Revitalized Areas
Authors: Wrana Jan , Struzik Wojciech , Jaromin-Gleń Katarzyna , Gleń Piotr
Published: December 2023

This paper discusses the application of a new honeycomb FCH HVAC (Free Cooling and Heating System, Heating, Ventilation, and Air Conditioning) ring network technology that reduces the primary energy consumption in existing infrastructure. The aim of the research is to evaluate the cost-environmental viability of upgrading the technical infrastructure and moving from traditional to newly designed green systems built on renewable energy sources. The results show that the energy capacity stored in groundwater is equivalent to 65% of building demand, resulting in a 60% reduction in CO2 emissions compared to a traditional HVAC system. The solution reduces the consumption of natural resources by using renewable energy sources with horizontal heat exchangers arranged in independent ring configurations.
Solid Biofuel Production from Biomass: Technologies, Challenges, and Opportunities for Its Commercial Production in Nigeria
Authors: Obi Okey Francis , Olugbade Temitope Olumide , Orisaleye Joseph Ifeolu , Pecenka Ralf
Published: December 2023

Producing durable and efficient solid biofuels should be an important consideration in Nigeria’s present economy due to the numerous advantages associated with it. It offers the benefit of energy generation, particularly in rural areas, and could potentially replace fossil fuels. However, the adoption and production of solid biofuels at commercial scale in Nigeria is limited by some challenges, including the lack of a developed supply chain structure, inadequate facilities, and air pollution. The present study summarizes the types of solid biofuel production technologies deployed in Nigeria as well as the biomass feedstock utilized in the production of fuel briquettes and pellets. While opportunities exist in the gasification of biomass in Nigeria, direct combustion is a readily applicable fuel conversion process that can be utilized to generate electricity from solid biofuel. The major challenges surrounding the full adoption of solid biofuel production and utilization in Nigeria are highlighted. Among others, promotion of clean energy alternatives, investments and financial incentives, sustainable renewable energy policy and energy transition plan, and legislative backing are identified as factors that could accelerate the commercial production and adoption of solid biofuel in Nigeria.
Seasonal Dynamics of Soil Respiration and Its Autotrophic and Heterotrophic Components in Subtropical Camphor Forests
Authors: He Ping , Yan Wende , Peng Yuanying , Lei Junjie , Zheng Wei , Zhang Yi , Qi Yaqin , Chen Xiaoyong
Published: December 2023

On a global scale, soil respiration (Rs), representing the CO2 flux between the soil surface and the atmosphere, ranks as the second-largest terrestrial carbon (C) flux. Understanding the dynamics between Rs and its autotrophic (Ra) and heterotrophic (Rh) components is necessary for accurately evaluating and predicting global C balance and net ecosystem production under environmental change. In this study, we conducted a two-year root exclusion experiment in subtropical China’s Camphor (Cinnamomum camphora (L.) Presl.) forests to assess seasonal changes in Ra and Rh and their relative contributions to Rs. Additionally, we examined the influence of environmental factors on the dynamics of Ra, Rh, and Rs. Our results showed that seasonal mean Rs values were 2.88 µmol m−2 s−1, with mean Ra and Rh of 1.21 and 1.67 µmol m−2 s−1, respectively, in the studied forests. On an annual basis, the annual values of mean Rs in the studied forests were 405 ± 219 g C m−2 year−1, with Rh and Ra accounting for 240 ± 120 and 164 ± 102 g C m−2 year−1, respectively. The seasonal mean ratio of Rh to Rs (Rh/Rs) was 58%, varying from 45 to 81%. Seasonal changes in Rs and Rh were strongly correlated with soil temperature but not soil water content. Both Rh and Rs increased exponentially with the average soil temperature measured in the topsoil layer (about 5 cm), with Q10 values of 2.02 and 1.73 for Rh and Rs, respectively. Our results suggest that the composition and activity of soil microbes and fauna play a primary role in releasing carbon flux from soil to the atmosphere in the studied forest ecosystems.
Chemical Analysis of Sexual Lubricant Residue: A Comparison of Medical Examination Swabs Analyzed Using Spectroscopic Techniques
Authors: Best Safiya J. , Thomas Santana , Flynn Nancy , Bridge Candice
Published: December 2023

Sexual assault kits are the standard method for collecting and preserving sexual assault evidence. During the sexual assault examination, swabs are commonly used to collect bodily fluids as sexual assault evidence from the vagina, anus, mouth, and skin. The type of fiber swab used during collection can greatly influence the recovery of the substrate. In cases where lubricant residue may be present, it would be useful to identify the swab type that would be the most efficient in the collection of lubricant residues. In this study, four types of swabs with different fibers (i.e., cotton, polyester, rayon, and foam) with sexual lubricants present, were extracted in various solvents. The extracts were analyzed using attenuated total reflectance Fourier-transform infrared (ATR-FTIR) and Raman spectroscopy. The Pearson correlation coefficient (PCCs) test was applied to determine a pairwise comparison between swab lube extracts and the standard lubricant reference. Visual comparisons of the lubricant reference, blank fiber swab, and the fiber lubricant extract were used to determine peak overlap, significance, and matrix interference.
Otsu Image Segmentation Algorithm Based on Hybrid Fractional-Order Butterfly Optimization
Authors: Ma Yu , Ding Ziqian , Zhang Jing , Ma Zhiqiang
Published: December 2023

To solve the drawbacks of the Otsu image segmentation algorithm based on traditional butterfly optimization, such as slow convergence speed and poor segmentation accuracy, this paper proposes hybrid fractional-order butterfly optimization with the Otsu image segmentation algorithm. G-L-type fractional-order differentiation is combined with the algorithm’s global search to improve the position-updating method, which enhances the algorithm’s convergence speed and prevents it from falling into local optima. The sine-cosine algorithm is introduced in the local search step, and Caputo-type fractional-order differentiation is used to avoid the disadvantages of the sine-cosine algorithm and to improve the optimization accuracy of the algorithm. By dynamically converting the probability, the ratio of global search to local search is changed to attain high-efficiency and high-accuracy optimization. Based on the 2-D grayscale gradient distribution histogram, the trace of discrete matrices between classes is chosen as the fitness function, the best segmentation threshold is searched for, image segmentation is processed, and three categories of images are chosen to proceed with the segmentation test. The experimental results show that, compared with traditional butterfly optimization, the convergence rate of hybrid fractional-order butterfly optimization with the Otsu image segmentation algorithm is improved by about 73.38%; meanwhile, it has better segmentation accuracy than traditional butterfly optimization.
Hard-to-Heal Wound Healing: Superiority of Hydrogel EHO-85 (Containing Olea europaea Leaf Extract) vs. a Standard Hydrogel. A Randomized Controlled Trial
Authors: Verdú-Soriano José , Casado-Díaz Antonio , de Cristino-Espinar Marisol , Luna-Morales Silvia , Dios-Guerra Caridad , Moreno-Moreno Paloma , Dorado Gabriel , Quesada-Gómez José Manuel , Rodríguez-Mañas Leocadio , Lázaro-Martínez José Luis
Published: December 2023

Chronic wounds, especially those that are hard-to-heal, constitute a serious public-health problem. Although progress has been made in the development of wound dressings for healing, there is little high-quality evidence of their efficacy, with no evidence of superiority in the use of one hydrogel over another. To evaluate the superiority of a hydrogel (EHO-85), containing Olea europaea leaf extract (OELE), over a standard hydrogel (SH), the promotion and/or improvement of healing of difficult-to-heal wounds was compared in a prospective, parallel-group multicenter, randomized, observer-blinded, controlled trial (“MACAON”). Non-hospitalized patients with pressure, venous or diabetic foot-ulcers difficult-to-heal were recruited and treated with standard care, and EHO-85 (n = 35) or VariHesive (n = 34) as SH. Wound-area reduction (WAR; percentage) and healing rate (HR; mm2/day) were measured. EHO-85 showed a statistically significant superior effect over VariHesive. At the end of the follow-up period, the relative WAR decreased by 51.6% vs. 18.9% (p < 0.001), with a HR mean of 10.5 ± 5.7 vs. 1.0 ± 7.5 mm2/day (p = 0.036). EHO-85 superiority is probably based on its optimal ability to balance the ulcer bed, by modulating pH and oxidative stress. That complements the wetting and barrier functions, characteristics of conventional hydrogels. These results support the use of EHO-85 dressing, for treatment of hard-to-heal ulcers. Trial Registration AEMPS:PS/CR623/17/CE.
Effect of Phytic Acid Addition on the Structure of Collagen-Hyaluronic Acid Composite Gel
Authors: Nashchekina Yuliya , Guryanov Evgeny , Lihachev Alexey , Vaganov Gleb , Popova Elena , Mikhailova Natalya , Nashchekin Alexey
Published: December 2023

Composite collagen gels with hyaluronic acid are developed tissue-engineered structures for filling and regeneration of defects in various organs and tissues. For the first time, phytic acid was used to increase the stability and improve the mechanical properties of collagen gels with hyaluronic acid. Phytic acid is a promising cross-linker for collagen hydrogels and is a plant-derived antioxidant found in rich sources of beans, grains, and oilseeds. Phytic acid has several benefits due to its antioxidant, anticancer, and antitumor properties. In this work, studies were carried out on the kinetics of the self-assembly of collagen molecules in the presence of phytic and hyaluronic acids. It was shown that both of these acids do not lead to collagen self-assembly. Scanning electron microscopy showed that in the presence of phytic and hyaluronic acids, the collagen fibrils had a native structure, and the FTIR method confirmed the chemical cross-links between the collagen fibrils. DSC and rheological studies demonstrated that adding the phytic acid improved the stability and modulus of elasticity of the collagen gel. The presence of hyaluronic acid in the collagen gel slightly reduced the effect of phytic acid. The presence of phytic acid in the collagen gel improved the stability of the scaffold, but, after 1 week of cultivation, slightly reduced the viability of mesenchymal stromal cells cultured in the gel. The collagen type I gel with hyaluronic and phytic acids can be used to replace tissue defects, especially after the removal of cancerous tumors.