bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiparametric magnetic resonance imaging for the differential diagnosis between granulomatous prostatitis and prostate cancer: a literature review to an intriguing diagnostic challenge
Authors: Gaudiano Caterina , Renzetti Benedetta , De Fino Cristina , Corcioni Beniamino , Ciccarese Federica , Bianchi Lorenzo , Schiavina Riccardo , Droghetti Matteo , Giunchi Francesca , Brunocilla Eugenio , Fiorentino Michelangelo
Published: June 2023

Multiparametric magnetic resonance imaging (mpMRI) is currently the most effective diagnostic tool for detecting prostate cancer (PCa) and evaluating adenocarcinoma-mimicking lesions of the prostate gland, among which granulomatous prostatitis (GP) represents the most interesting diagnostic challenge. GP consists of a heterogeneous group of chronic inflammatory lesions that can be differentiated into four types: idiopathic, infective, iatrogenic, and associated with systemic granulomatous disease. The incidence of GP is growing due to the increase in endourological surgical interventions and the adoption of intravesical instillation of Bacillus Calmette-Guerin in patients with non-muscle invasive bladder cancer; therefore, the difficulty lies in identifying specific features of GP on mpMRI to avoid the use of transrectal prostate biopsy as much as possible.
Breastfeeding during the COVID-19 pandemic
Authors: Chanda Bwalya Mpelwa , Chen Xiao-Qing
Published: June 2023

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused many significant changes to all aspects of day to day life. The disease has spread and reached pandemic proportions. The principle route of transmission is the respiratory route. Infants, pregnant women and breastfeeding mothers have all been affected. Many interventions and guidelines from important societies have been instituted in order to curb the transmission of the disease. These have involved both pharmacological and non-pharmacological methods. COVID-19 vaccines have also emerged as important methods of primary prevention of the disease. But several questions have been raised concerning the safety and efficacy of their use in pregnant and breastfeeding mothers. It has also not been clear if the vaccines are effective in generating a robust immune response in the pregnant women and breastfeeding mothers to confer passive immunity to the fetuses and infants, respectively. And they have not been tested in infants. The aspect of infant feeding has equally been affected. Although breast milk has not been known to serve as the vehicle of transmission of the virus, there is still some lack of uniformity of practice regarding breastfeeding when a mother has SARS-CoV-2 infection. This has led to infant feeding being done by the use of commercial formula feeds, pasteurized human donor breast milk, feeding on the mother's own expressed breast milk by a care giver and directly breastfeeding with skin to skin contact. This is despite breast milk being the most physiologically appropriate type of feed for infants. Therefore the pertinent question remains; should breastfeeding continue during the pandemic continue? This review also seeks to analyse the vast amount of scientific information regarding the subject and to synthesize science-based information
Pathophysiology of bone disease in chronic kidney disease: from basics to renal osteodystrophy and osteoporosis
Authors: Aguilar Armando , Gifre Laia , Ureña-Torres Pablo , Carrillo-López Natalia , Rodriguez-García Minerva , Massó Elisabeth , da Silva Iara , López-Báez Víctor , Sánchez-Bayá Maya , Prior-Español Águeda , Urrutia Marina , Paul Javier , Bustos Misael C. , Vila Anna , Garnica-León Isa , Navarro-González Juan F. , Mateo Lourdes , Bover Jordi
Published: June 2023

Chronic kidney disease (CKD) is a highly prevalent disease that has become a public health problem. Progression of CKD is associated with serious complications, including thesystemicCKD-mineral and bone disorder (CKD-MBD). Laboratory, bone and vascular abnormalities define this condition, and all have been independently related to cardiovascular disease and high mortality rates. The “old” cross-talk between kidney and bone (classically known as “renal osteodystrophies”) has been recently expanded to the cardiovascular system, emphasizing the importance of the bone component of CKD-MBD. Moreover, a recently recognized higher susceptibility of patients with CKD to falls and bone fractures led to important paradigm changes in the new CKD-MBD guidelines. Evaluation of bone mineral density and the diagnosis of “osteoporosis” emerges in nephrology as a new possibility “if results will impact clinical decisions”. Obviously, it is still reasonable to perform a bone biopsy if knowledge of the type of renal osteodystrophy will be clinically useful (lowversushigh turnover-bone disease). However, it is now considered that the inability to perform a bone biopsy may not justify withholding antiresorptive therapies to patients with high risk of fracture. This view adds to the effects of parathyroid hormone in CKD patients and the classical treatment of secondary hyperparathyroidism. The availability of new antiosteoporotic treatments bring the opportunity to come back to the basics, and the knowledge of new pathophysiological pathways [OPG/RANKL (LGR4); Wnt-ß-catenin pathway], also affected in CKD, offers great opportunities to further unravel the complex physiopathology of CKD-MBD and to improve outcomes.
Construction of a high-density genetic linkage map and QTL mapping for bioenergy-related traits in sweet sorghum [Sorghum bicolor (L.) Moench]
Authors: Guden Birgul , Yol Engin , Erdurmus Cengiz , Lucas Stuart James , Uzun Bulent
Published: June 2023

Sorghum is an important but arguably undervalued cereal crop, grown in large areas in Asia and Africa due to its natural resilience to drought and heat. There is growing demand for sweet sorghum as a source of bioethanol as well as food and feed. The improvement of bioenergy-related traits directly affects bioethanol production from sweet sorghum; therefore, understanding the genetic basis of these traits would enable new cultivars to be developed for bioenergy production. In order to reveal the genetic architecture behind bioenergy-related traits, we generated an F2 population from a cross between sweet sorghum cv. ‘Erdurmus’ and grain sorghum cv. ‘Ogretmenoglu’. This was used to construct a genetic map from SNPs discovered by double-digest restriction-site associated DNA sequencing (ddRAD-seq). F3 lines derived from each F2 individual were phenotyped for bioenergy-related traits in two different locations and their genotypes were analyzed with the SNPs to identify QTL regions. On chromosomes 1, 7, and 9, three major plant height (PH) QTLs (qPH1.1, qPH7.1, and qPH9.1) were identified, with phenotypic variation explained (PVE) ranging from 10.8 to 34.8%. One major QTL (qPJ6.1) on chromosome 6 was associated with the plant juice trait (PJ) and explained 35.2% of its phenotypic variation. For fresh biomass weight (FBW), four major QTLs (qFBW1.1, qFBW6.1, qFBW7.1, and qFBW9.1) were determined on chromosomes 1, 6, 7, and 9, which explained 12.3, 14.5, 10.6, and 11.9% of the phenotypic variation, respectively. Moreover, two minor QTLs (qBX3.1 and qBX7.1) of Brix (BX) were mapped on chromosomes 3 and 7, explaining 8.6 and 9.7% of the phenotypic variation, respectively. The QTLs in two clusters (qPH7.1/qBX7.1 and qPH7.1/qFBW7.1) overlapped for PH, FBW and BX. The QTL, qFBW6.1, has not been previously reported. In addition, eight SNPs were converted into cleaved amplified polymorphic sequences (CAPS) markers, which can be easily detected by agarose gel electrophoresis. These QTLs and molecular markers can be used for pyramiding and marker-assisted selection studies in sorghum, to develop advanced lines that include desirable bioenergy-related traits.
Detection and differentiation of herbicide stresses in roses by Raman spectroscopy
Authors: Farber Charles , Shires Madalyn , Ueckert Jake , Ong Kevin , Kurouski Dmitry
Published: June 2023

Herbicide application is a critical component of modern horticulture. Misuse of herbicides can result in damage to economically important plants. Currently, such damage can be detected only at symptomatic stages by subjective visual inspection of plants, which requires substantial biological expertise. In this study, we investigated the potential of Raman spectroscopy (RS), a modern analytical technique that allows sensing of plant health, for pre-symptomatic diagnostics of herbicide stresses. Using roses as a model plant system, we investigated the extent to which stresses caused by Roundup (Glyphosate) and Weed-B-Gon (2, 4-D, Dicamba and Mecoprop-p (WBG), two of the most commonly used herbicides world-wide, can be diagnosed at pre- and symptomatic stages. We found that spectroscopic analysis of rose leaves enables ~90% accurate detection of Roundup- and WBG-induced stresses one day after application of these herbicides on plants. Our results also show that the accuracy of diagnostics of both herbicides at seven days reaches 100%. Furthermore, we show that RS enables highly accurate differentiation between the stresses induced by Roundup- and WBG. We infer that this sensitivity and specificity arises from the differences in biochemical changes in plants that are induced by both herbicides. These findings suggest that RS can be used for a non-destructive surveillance of plant health to detect and identify herbicide-induced stresses in plants.
Rapid molecular assay for the evaluation of clove essential oil antifungal activity against wheat common bunt
Authors: Valente Maria Teresa , Orzali Laura , Manetti Giuliano , Magnanimi Francesco , Matere Antonio , Bergamaschi Valentino , Grottoli Alessandro , Bechini Sara , Riccioni Luca , Aragona Maria
Published: June 2023

Common bunt of durum wheat (DW), Triticum turgidum L. ssp. durum (Desf.) Husn., is caused by the two closely related fungal species belonging to Tilletia genus (Tilletiales, Exobasidiomycetes, Ustilaginomycotina): Tilletia laevis Kühn (syn. T. foetida (Wallr.) Liro.) and T. caries (DC) Tul. (syn. T. tritici (Bjerk.) G. Winter). This is one of the most devastating diseases in wheat growing areas worldwide, causing considerable yield loss and reduction of wheat grains and flour quality. For these reasons, a fast, specific, sensitive, and cost-effective method for an early diagnosis of common bunt in wheat seedlings is urgent. Several molecular and serological methods were developed for diagnosis of common bunt in wheat seedlings but at late phenological stages (inflorescence) or based on conventional PCR amplification, with low sensitivity. In this study, a TaqMan Real Time PCR-based assay was developed for rapid diagnosis and quantification of T. laevis in young wheat seedlings, before tillering stage. This method, along with phenotypic analysis, was used to study conditions favoring pathogen infection and to evaluate the effectiveness of clove oil-based seed dressing in controlling the disease. The overall results showed that: i) the Real Time PCR assay was able to quantify T. laevis in young wheat seedlings after seed dressing by clove oil in different formulations, greatly reducing times of analysis. It showed high sensitivity, detecting up to 10 fg of pathogen DNA, specificity and robustness, allowing to directly analyze crude plant extracts and representing a useful tool to speed up the tests of genetic breeding for disease resistance; ii) temperature was a critical point for disease development when using wheat seeds contaminated by T. laevis spores; iii) at least one of the clove oil-based formulations tested was able to efficiently control wheat common bunt, suggesting that clove oil dressing could represent a promising tool for managing the disease, especially in sustainable farming.
Influence of drought stress and mycorrhizal (Funneliformis mosseae) symbiosis on growth parameters, chlorophyll fluorescence, antioxidant activity, and essential oil composition of summer savory (Satureja hortensis L.) plants
Authors: Rasouli Farzad , Amini Trifa , Skrovankova Sona , Asadi Mohammad , Hassanpouraghdam Mohammad Bagher , Ercisli Sezai , Buckova Martina , Mrazkova Martina , Mlcek Jiri
Published: June 2023

Introduction

Drought stress unfavorably influences the growth and physiological traits of plants in the arid and semi-arid regions of the world. This study aimed to determine the effects of arbuscular mycorrhiza fungi (AMF; Funneliformis mosseae) inoculation on the physiological and biochemical responses of summer savory (Satureja hortensis L.) under different irrigation regimes.

Methods

The first factor was different irrigation regimes, including no drought stress (100% field capacity; FC), moderate drought stress (60% FC), and severe drought stress (30% FC); the second factor included the plants without AMF (AMF0) and with AMF inoculation (AMF1).

Results

The results showed that better values, higher plant height, shoot mass (fresh and dry weight), relative water content (RWC), membrane stability index (MSI), photosynthesis pigments, Fv, Fm, Fv/Fm, and total soluble proteins were obtained in the plants inoculated with AMF. The highest values were obtained for plants with no drought stress, then the plants subjected to AMF1 under 60% FC, and the lowest ones for plants under 30% FC without AMF inoculation. Thus, these properties are reduced under moderate and severe drought stress. At the same time, the utmost activity of superoxide dismutase (SOD), ascorbate peroxidase (APX), guaiacol peroxidase (GPX), and the highest malondialdehyde (MDA), H2O2, proline, and antioxidant activity (TAA) were achieved for 30% FC + AMF0. It was also found that AMF inoculation improved essential oil (EO) composition, also as EO obtained from plants under drought stress. Carvacrol (50.84-60.03%) was the dominant component in EO; γ-terpinene (19.03-27.33%), p-cymene, α-terpinene, and myrcene, were recognized as other important components in EO. The higher carvacrol and γ-terpinene contents were obtained from summer savory plants with AMF inoculation and the lowest for plants without AMF and under 30% FC.

Conclusion

According to the present findings, using AMF inoculation could be a sustainable and eco-friendly approach to improve physiological and biochemical characteristics and the essential oil quality of summer savory plants under water shortage conditions.
Solidarities of citizenship
Authors: Stevens Jacqueline
Published: June 2023

This essay contrasts the trajectory of Engin Isin's work since Being Political (2002) with a very different intellectual path pursued among scholars of a younger generation. Isin moves away from his initial critiques of citizenship and 10 years later proposes “citizenship without frontiers,” a way of understanding emancipatory interventions of active citizens in opposition to state violence. During this same time frame, other political theorists began to reject “citizenship” entirely. Whereas, Isin's oeuvre since Being Political incorporates the principles of creativity and resistance of “being political” into a more expansive concept of “citizenship,” other theorists began denouncing citizenship as of a piece with colonialism, capitalism, and neoliberalism. Such reactions expressly rejected efforts to recuperate citizenship for causes that oppose domination and oppression. This essay analyzes arguments antagonistic to citizenship claims through the lens of Isin's work, focusing in particular on competing views on nativism, Indigeneity, and nationality. The Conclusion considers recent examples of activist citizens and citizens without frontiers pursuing political solidarities along the lines Isin proposes.1
Emotional labor and job satisfaction among nurses: The mediating effect of nurse–patient relationship
Authors: Xu Yi-wei , Fan Ling
Published: June 2023

Emotional labor is considered an important part of the role in the nursing field. Previous studies have found inconsistencies between emotional labor and job satisfaction of nurses, this is due to the relationship between them being affected by other factors. However, the current nurse-patient relationship is tense and leads to an unsafe and unstable working environment for nurses. It has yet to be confirmed whether the nurse-patient relationship can be used as a mediating variable to further explain the association that exists between emotional labor and job satisfaction. Therefore, this study tested the mediating effect of the nurse-patient relationship between emotional labor and job satisfaction among Chinese nurses. A total of 496 nurses were included in the study. Data collection was from December 2021 to March 2022 using the convenience sampling method. SPSS 26.0 and AMOS 23.0 software were used to perform structural equation modeling and analyze the relationship between variables. The results showed surface acting negatively affected nurse-patient relationships and job satisfaction, contrary to deep acting and naturally felt emotions. The parallel mediation of nurse-patient trust and patient-centered nursing in the relationship between emotional labor and job satisfaction was found to be statistically significant. Our study highlighted the important mediation of nurse-patient trust and the importance of the positive effects of emotional labor. Future studies can use these findings as a reference to develop interventions.
Construct validity of the General Health Questionnaire (GHQ-12) in patients with COVID-19 and its demographic and medical correlates
Authors: Habibi Asgarabad Mojtaba , Etesam Farnaz , Salehi Yegaei Pardis , Vahabi Zahra , Akbari Saneh Niusha , Fathi Fatemeh , Ghosi Fatemeh , Wiium Nora
Published: June 2023

Introduction

The present cross sectional study aimed to evaluate the construct and criterion validity, reliability, and gender and age differences of the 12-item General Health Questionnaire (GHQ-12) among hospitalized patients with COVID-19 in 2020. The criterion validity was assessed via its link with perceived stress, sleep quality, daily life activities, and demographic and medical characteristics.

Methods

A total of 328 COVID-19 patients (55.8% men; Mage = 50.49, SD = 14.96) completed the GHQ-12, the Perceived Stress Scale (PSS), the Pittsburgh Sleep Quality Index (PSQI), the Activities of Daily Life (ADL)-Katz Scale, and the Lawton Instrumental Activities of Daily Living Scale (IADL).

Results

Among 13 factorial models, the three-factor model (successful coping, self-esteem, and stress) was shown to have the best fit. GHQ-12 was positively associated with PSQI, PSS, Hyperlipidemia, psychiatry disorders, hospitalization duration, the change in sleep time, and use of sleeping pills, and negatively correlated with educational level, and the number of family members. The GHQ-12 also had a negative correlation with ADL and IADL in over 60 years of age group. Females scored higher on total GHQ-12 scores, compared to males. Finally, the hospitalization duration was longer for patients over 60 (mean = 8.8 days, SD = 5.9) than patients under 60 (mean = 6.35 days, SD = 5.87).

Discussion

Overall, the findings provided evidence that mental distress in patients with COVID-19 is correlated with high perceived stress, low sleep quality, low ADL and IADL, and a range of demographic features and medical conditions. Designing psychological interventions for these patients that target the aforementioned correlates of mental distress is warranted.
Academic stress and academic burnout in adolescents: a moderated mediating model
Authors: Gao Xinhang
Published: June 2023

Objective

This study aims to investigate the relationship and mechanisms of action among academic stress, academic anxiety, academic self-efficacy, and academic burnout among adolescents.

Methods

A study of 929 Chinese adolescents (53.71% males, mean age = 11.94 years, SD = 0.77) was conducted using the Study Stress Questionnaire, Academic Anxiety Subscale, Junior Middle School Students’ Learning Weariness Scale, and the Academic Self-efficacy Questionnaire.

Results

①Academic stress was significantly and positively correlated with academic anxiety and academic burnout, and significantly and negatively correlated with academic self-efficacy. ②Academic anxiety partially mediated the relationship between academic stress and academic burnout. ③Academic self-efficacy significantly moderated the direct effect of academic stress on academic burnout, and higher academic self-efficacy could buffer the negative effect of academic stress. ④Academic self-efficacy significantly moderated the second half of the mediated model’s path (academic anxiety → academic burnout), that is, low academic self-efficacy amplified the risk effect of academic anxiety on academic burnout.

Conclusion

Academic anxiety partially mediates the relationship between academic stress and academic burnout, and this mediating role is moderated by academic self-efficacy.
Between suffering and coping: burnout in female medical doctors in South Africa
Authors: Oosthuizen Rudolf M. , Mashego Keitumetse , Mayer Claude-Hélène
Published: June 2023

Burnout is described as emotional and physical exhaustion, reduced accomplishment, together with an outlook of inadequacy and cynicism related to job stress. It has a harmful impact globally, especially in developing countries, such as South Africa. This study is a phenomenological collective case study focusing on burnout experience in a sample of female medical doctors working in a South African public hospital. Based on ongoing explorations of burnout themes, empirically based intervention strategies are needed to be developed and presented for the South African public health sector to prevent stress-related burnout. The findings support the trend in literature that burnout is an overwhelming experience for female medical doctors in South Africa. The study presents voices of female medical doctors, their concerns, the causes for burnout and their coping mechanisms. It provides a strong contribution to exploring and presenting women’s experiences in working in the medical field in South Africa from a positive psychology perspective. The findings indicate the struggles and the coping mechanisms of female medical doctors working in the field.
COVID-19-related anxiety and the role of social media among Canadian youth
Authors: Kim Soyeon , Belfry Kimberly D. , Crawford Jennifer , MacDougall Arlene , Kolla Nathan J.
Published: June 2023

Background

Current literature indicates that safety measures, including lockdowns during the COVID-19 pandemic, severely disrupted our lifestyle, marked by increased screen time. The increased screen time is mostly associated with exacerbated physical and mental wellbeing. However, the studies that examine the relationship between specific types of screen time and COVID-19-related anxiety among youth are limited.

Methods

We examined the usage of passive watching, social media, video games, and educational screen time and COVID-19-related anxiety at the 5-time points (Early-Spring 2021, Late-Spring 2021, Fall 2021, Winter 2022, and Spring 2022) among youth in Southern Ontario, Canada (N = 117, mean age = 16.82, male = 22%, non-White = 21%) and investigated the role of 4 types of screen time in COVID-19 related anxiety. COVID-related anxiety was measured using the Coronavirus Anxiety Scale (CAS). Descriptive statistics examined the binary relationships between demographic factors, screen time, and COVID-related anxiety. Also, partially adjusted and fully adjusted binary logistic regression analyses were conducted to examine the association between the types of screen time and COVID-19-related anxiety.

Results

During the late Spring of 2021, when the provincial safety restrictions were most stringent, screen time was the highest among the 5 data collection time points. Further, adolescents experienced the highest COVID-19-related anxiety during this period. On the other hand, young adults experienced the highest COVID-19-related anxiety during Spring 2022. In a partially adjusted model (accounting for other types of screen time), engaging in 1–5 h per day on social media increased the likelihood of experiencing COVID-19-related anxiety compared to those who spend less than 1 h per day (OR = 3.50, 95%CI = 1.14–10.72, p < 0.05). Other types of screen time was not significantly associated with COVID-19-related anxiety. In a fully adjusted model (accounting for age, sex and ethnicity besides four types on screen time), 1–5 h per day of social media remained significantly associated with COVID-19-related anxiety (OR = 4.08, 95%CI = 1.22–13.62, p < 0.05).

Conclusion

Our findings suggest that COVID-19-related anxiety is associated with youth engagement in social media during the COVID-19 pandemic. Clinicians, parents, and educators should work collaboratively to provide developmentally appropriate approaches to reduce the negative social media impact on COVID-19-related anxiety and promote/foster resiliency in our community during the recovery period.
Efficacy and tolerability of minocycline in depressive patients with or without treatment-resistant: a meta-analysis of randomized controlled trials
Authors: Qiu Youjia , Duan Aojie , Yin Ziqian , Xie Minjia , Chen Zhouqing , Sun Xiaoou , Wang Zhong , Zhang Xuwei
Published: June 2023

Background

Minocycline, an antibiotic with anti-inflammatory, antioxidant, and neuroprotective properties, has been used for treating psychiatric disorders in research. This systematic review aimed to evaluate the efficacy and tolerability of minocycline in patients having depression with or without treatment-resistance.

Methods

Electronic databases including Embase, PubMed, and the Cochrane library were searched for relevant studies published up to October 17, 2022. The primary efficacy outcome was the change in depression severity scores and the secondary efficacy outcomes included the changes in Clinical Global Impression (CGI) and Beck Depression Inventory (BDI) scores and the incidence of response and partial response. Safety outcomes were evaluated based on the incidence of classified adverse events and all-cause discontinuation.

Results

Five studies with 374 patients were selected for analysis. The minocycline group demonstrated a significant reduction in depression severity scale (standardized mean difference [SMD]: −0.59, 95% confidence interval [CI]: −0.98 to −0.20, P = 0.003) and CGI (SMD: −0.28, 95% CI: −0.56 to −0.01, P = 0.042) scores; however, no statistical difference was found in terms of the BDI score, response, and partial response. No significant differences were found between the groups in terms of adverse events (other than dizziness) and discontinuation rates. Subgroup analysis showed that minocycline was also effective in reducing depression severity scores in treatment-resistant depression (SMD: −0.36, 95% CI: −0.64 to −0.09, P = 0.010). Subgroup analysis of Hamilton Depression Rating Scale (17-item) scores showed a statistical difference in response in patients with depression (relative risk: 2.51, 95% CI: 1.13 to 5.57, P = 0.024).

Conclusions

Minocycline may improve depressive symptoms and augment response to treatment in patients with depression irrespective of treatment-resistance. However, clinical trials with large sample sizes are warranted for evaluating long-term outcomes with minocycline.

Systematic review registration

https://inplasy.com/inplasy-2022-12-0051/.
Improvement in self-reported cognitive functioning but not in rumination following online working memory training in a two-year follow-up study of remitted major depressive disorder
Authors: Ronold Eivind Haga , Myklebost Sunniva Brurok , Hammar Åsa
Published: June 2023

Self-reported subjective cognitive difficulties (subjective deficits) and rumination are central residual cognitive symptoms following major depressive disorder (MDD). These are risk factors for more a severe course of illness, and despite the considerable relapse risk of MDD, few interventions target the remitted phase, a high-risk period for developing new episodes. Online distribution of interventions could help close this gap. Computerized working memory training (CWMT) shows promising results, but findings are inconclusive regarding which symptoms improve following this intervention, and its long-term effects. This study reports results from a longitudinal open-label two-year follow-up pilot-study of self-reported cognitive residual symptoms following 25 sessions (40 min), five times a week of a digitally delivered CWMT intervention. Ten of 29 patients remitted from MDD completed two-year follow-up assessment. Significant large improvements in self-reported cognitive functioning on the behavior rating inventory of executive function-adult version appeared after two-years (d = 0.98), but no significant improvements were found in rumination (d < 0.308) measured by the ruminative responses scale. The former showed moderate non-significant associations to improvement in CWMT both post-intervention (r = 0.575) and at two-year follow-up (r = 0.308). Strengths in the study included a comprehensive intervention and long follow-up time. Limitations were small sample and no control group. No significant differences between completers and drop-outs were found, however, attrition effects cannot be ruled out and demand characteristics could influence findings. Results suggested lasting improvements in self-reported cognitive functioning following online CWMT. Controlled studies with larger samples should replicate these promising preliminary findings.
Effects of infection prevention and control measures on patient and visitor violence against health workers in China during COVID-19 pandemic
Authors: Su Ke , Zhang Cheng , Huang Ju
Published: June 2023

Objective

To examine trends in patient and visitor violence (PVV) among large public hospitals from 2016 to 2020 in China, and investigate the effects of infection prevention and control (IPC) measures on PVV during the COVID-19 pandemic.

Methods

The hospital-level data of PVV used in this study from 2016 to 2020 in three cities in northern China were extracted from the database of the Medical Quality and Safety Notification System from 41 public hospitals. The difference-in-difference (DID) method was used to estimate the effects of IPC measures on PVV. The empirical strategy was to compare changes in the incidence rate of PVV in public hospitals where IPC measures were stricter to relatively weaker hospitals.

Results

From 2019 to 2020, the incidence rate of PVV decreases from 4.59 to 2.15% for high-IPC measure level hospitals and increases from 4.42 to 4.56% for medium-IPC measure level hospitals. The results from the DID models showed that as the IPC measure level increased, the incidence rate of PVV (β = −3.12, 95% CI = −5.74 ~ −0.50) decreased more significantly based on controlling for hospital fixed effects and time trends.

Conclusion

The multi-dimensional and comprehensive IPC measures throughout the pandemic in China have not only controlled the pandemic, but also directly or indirectly reduced the incidence rate of PVV by alleviating the stress of health workers and the crowded working environment, creating a good order of admission, and reducing patient waiting time.
Factors associated with perceived caregivers' willingness to provide care among older adults with disabilities in China
Authors: Sun Chang , Meng Dijuan
Published: June 2023

Objective

The aim of this study was to analyze the status quo and associated factors of care recipients' perceptions of caregivers' willingness to provide care among disabled older adults in China. Thus, this study contributes to our understanding of vulnerable older populations who are at a high risk of receiving support from informal caregivers who are unable or unwilling to take the caregiver role.

Methods

We analyzed the cross-sectional data of 3,539 disabled older adults who received informal care at home from the seventh wave of the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS). Multiple logistic regression models were used to examine the variables associated with the respondents' perceived caregivers' willingness to care from five aspects: respondents' sociodemographic attributes, health-related data, family endowment, access to health care services and community-based long-term care services (CBLTCS).

Results

This study found that the majority of disabled older adults (90.9%) had a positive attitude toward their caregivers' willingness to care and the care they received; however, 7.0% of the adults were concerned about their caregivers' ability to handle the care. Moreover, there was a small number of disabled older people (2.1%) who felt that their caregivers were reluctant to care or lacked patience. The results from the multiple logistic regression showed that disabled older adults with socioeconomic disadvantages (living in rural areas, being poor and with no children who frequently visited) or high demand (with severe disabilities or cognitive impairment) were more likely to consider that their caregivers needed respite care. Those adults with anxiety symptoms, a lower amount of care time, poor self-rated financial status and poor accessibility to health care services were more likely to report that their caregivers were reluctant to administer care.

Conclusion

This study found that living in rural areas, being poor, with no children who frequently visited, severe disabilities or CI were positively associated the care recipients' perception that caregivers needed respite care. While anxiety symptoms, a lower amount of care time, poor self-rated financial status and poor accessibility to health care services were significantly associated with care recipients' perception of caregivers' reluctance to care. Our findings highlight the awareness of monitoring informal carers' willingness to care or capability to enact caring tasks.
Experiences of environmental services workers in a tertiary hospital in Asia during the COVID-19 pandemic: a qualitative study
Authors: Ng Qin Xiang , Koh Nicholas Ye Kai , Xin Xiaohui , Zainal Humairah , Tan Jack Thian , Thumboo Julian , Fong Kok Yong
Published: June 2023

Background

The Coronavirus Disease 2019 (COVID-19) pandemic has had a significant impact on all walks of life, in particular, environmental services workers in healthcare settings had higher workload, increased stress and greater susceptibility to COVID-19 infections during the pandemic. Despite extensive literature describing the impact of the pandemic on healthcare workers such as doctors and nurses, studies on the lived experiences of environmental services workers in healthcare settings are sparse and none has been conducted in the Asian context. This qualitative study thus aimed to examine the experiences of those who worked for a year of the COVID-19 pandemic.

Methods

A purposive sample of environmental services workers was recruited from a major tertiary hospital in Singapore. Semi-structured interviews were conducted in-person, lasting around 30min, and included open-ended questions pertaining to five main domains: work experiences during COVID-19, training and education needs, resource and supplies availability, communication with management and other healthcare staff, and perceived stressors and support. These domains were identified based on team discussions and literature review. The interviews were recorded and transcribed for thematic analysis, as guided by Braun and Clarke.

Results

A total of 12 environmental services workers were interviewed. After the first seven interviews, no new themes emerged but an additional five interviews were done to ensure data saturation. The analysis yielded three main themes and nine subthemes, including (1) practical and health concerns, (2) coping and resilience, and (3) occupational adaptations during the pandemic. Many expressed confidence in the preventive efficacy of proper PPE, infection control practice and COVID-19 vaccination in protecting them against COVID-19 and severe illness. Having prior experience with infectious disease outbreaks and previous training in infection control and prevention appeared to be useful as well for these workers. Despite the various challenges presented by the pandemic, they could still find meaning in their everyday work by positively impacting the wellbeing of patients and other healthcare workers in the hospital.

Conclusion

Besides uncovering the concerns shared by these workers, we identified helpful coping strategies, resilience factors and certain occupational adaptations, which have implications for future pandemic planning and readiness.
Comparative effectiveness of school-based exercise interventions on physical fitness in children and adolescents: a systematic review and network meta-analysis
Authors: Wu Jin , Yang Yuhang , Yu Huasen , Li Liqiang , Chen Yanying , Sun Youping
Published: June 2023

Background

Schools provide a favorable setting for health education, however, the most effective school-based exercise mode for improving physical fitness remains unclear. This network meta-analysis was designed to assess and rank the comparative efficacy of six exercise modalities on physical fitness indicators in a school-based setting.

Methods

An online search of the Web of Science, PubMed, SPORTDiscus, and Scopus databases was conducted. Randomized and quasi-randomized controlled trials were considered. Outcomes included measures of anthropometry and body composition, muscular fitness, and cardiorespiratory fitness. Data were pooled with a random effects model using the frequentist framework.

Results

A total of 66 studies with 8,578 participants (48% girls) were included. High-intensity interval training was the most effective intervention reducing body mass index (mean difference (MD) = −0.60 kg·m−2, 95% confidence interval (95%CI) = −1.04 to −0.15, p = 0.009), elevating VO2max (MD = 3.59 mL·kg−1·min−1, 95% CI = 2.45 to 4.74, p < 0.001), and 20-meter sprint performance (MD = −0.35 s, 95% CI = −0.55 to −0.14, p = 0.001). Aerobic training had the highest probability of reducing waist circumference (standardized mean difference (SMD) = −0.60, 95% CI = −0.88 to −0.32, p < 0.001). Active video games emerged as a promising modality for improving countermovement jump (MD = 2.43 cm, 95% CI = 0.06 to 4.80, p = 0.041) and shuttle running performance (SMD = 0.86, 95% CI = 0.29 to 1.43, p = 0.003). Strength training was the best exercise mode for improving standing long jump performance (SMD = 1.03, 95% CI = 0.07 to 1.98, p = 0.035) while combined training was rated the first for decreasing body fat percent (MD = −2.56%, 95% CI = −4.73 to −0.40, p = 0.022) and increasing push-up repetitions (SMD = 3.59, 95% CI = 0.81 to 6.37, p = 0.012).

Conclusion

School-based exercise interventions have multiple effects on physical fitness. The findings of this study will help to inform physical education teachers and coaches how best to deliver exercise programs in a school setting. Since the study was limited by the original research, the conclusions will require further verification using high-quality randomized controlled trials.

Systematic Review Registration

PROSPERO, Identifier: CRD42023401963.
Policy brief: adaptive cycling equipment for individuals with neurodevelopmental disabilities as durable medical equipment
Authors: Gannotti Mary E. , O’Neil Margaret E. , Fragala-Pinkham Maria , Gorton George E. , Whitney Daniel G.
Published: June 2023

- Durable medical equipment (DME) policies require that the equipment be medically necessary; however, adaptive cycling equipment (bicycles and tricycles) are usually not deemed medically necessary.

- Individuals with neurodevelopmental disabilities (NDD) are at high risk for secondary conditions, both physical and mental, that can be mitigated by increasing physical activity.

- Significant financial costs are associated with the management of secondary conditions.

- Adaptive cycling can provide improved physical health of individuals with NDD potentially reducing costs of comorbidities.

- Expanding DME policies to include adaptive cycling equipment for qualifying individuals with NDD can increase access to equipment.

- Regulations to ensure eligibility, proper fitting, prescription, and training can optimize health and wellbeing.

- Programs for recycling or repurposing of equipment are warranted to optimize resources.
Interhemispheric ionosphere-plasmasphere system shows a high sensitivity to the exospheric neutral hydrogen density: a caution of the global reference atmospheric model hydrogen density
Authors: Kotov Dmytro , Richards Phil G. , Reznychenko Maryna , Bogomaz Oleksandr , Truhlík Vladimír , Nossal Susan , Mierkiewicz Edwin , Zhivolup Taras , Domnin Igor , Miyoshi Yoshizumi , Tsuchiya Fuminori , Kumamoto Atsushi , Kasahara Yoshiya , Kitahara Masahiro , Nakamura Satoko , Matsuoka Ayako , Shinohara Iku , Hairston Marc
Published: June 2023

This study explores the impact of the exosphere hydrogen (H) density on the ionosphere-plasmasphere system using a model whose key inputs are constrained by ionosphere observations at both ends of the magnetic field line with an L-value of 1.75 in the American longitudinal sector during a period with low solar and magnetic activities. This study is the first to be validated by ground-based and satellite data in the plasmasphere and both hemispheres. The main finding is that the entire ionosphere-plasmasphere system is very sensitive to the neutral hydrogen density in the lower exosphere. It was found that an increase in the H density by a factor of 2.75 from the commonly accepted values was necessary to bring the simulated plasma density into satisfactory agreement with Arase satellite measurements in the plasmasphere and also with DMSP satellite measurements in the topside ionospheres of the northern and southern hemispheres. A factor of 2.75 increase in the H density increases the simulated plasma density in the afternoon plasmasphere up to ∼80% and in the nighttime topside ionosphere up to ∼100%. These results indicate prominently that using the commonly accepted empirical model of the H density causes unacceptable errors in the simulated plasma density of the near-Earth plasma shells. We alert the space science community of this problem.
Investigating short-term earthquake precursors detection through monitoring of total electron content variation in ionosphere
Authors: Zulhamidi Nur Fatin Irdina , Abdullah Mardina , Abdul Hamid Nurul Shazana , Yusof Khairul Adib , Bahari Siti Aminah
Published: June 2023

The effectiveness and accuracy of earthquake precursors are measured by the ability of the precursors to predict the time, epicentral distance, and magnitude of the earthquake for short-term earthquake prediction. Past articles were reviewed to examine various studies of short-term earthquake precursor detection, particularly those that involved monitoring variations in total electron content (TEC). In this review, we examine recent studies that explore the use of the TEC parameter in the Lithospheric-Atmospheric-Ionospheric (LAI) interaction to forecast earthquake characteristics, including detection time, epicentral distance, and magnitude. This review characterizes anomalous observations of TEC parameters that may be linked to subsequent seismic events and investigates their correlation with earthquake properties. It has been conclusively demonstrated that TEC parameters show significant variations prior to earthquakes, and these results can be used in combination with other parameters to forecast earthquake properties.
Case report: High-resolution, intra-operative µDoppler-imaging of spinal cord hemangioblastoma
Authors: Soloukey Sadaf , Verhoef Luuk , Generowicz Bastian S. , De Zeeuw Chris I. , Koekkoek Sebastiaan K. E. , Vincent Arnaud J. P. E. , Dirven Clemens M. F. , Harhangi Biswadjiet S. , Kruizinga Pieter
Published: June 2023

Surgical resection of spinal cord hemangioblastomas remains a challenging endeavor: the neurosurgeon’s aim to reach total tumor resections directly endangers their aim to minimize post-operative neurological deficits. The currently available tools to guide the neurosurgeon’s intra-operative decision-making consist mostly of pre-operative imaging techniques such as MRI or MRA, which cannot cater to intra-operative changes in field of view. For a while now, spinal cord surgeons have adopted ultrasound and its submodalities such as Doppler and CEUS as intra-operative techniques, given their many benefits such as real-time feedback, mobility and ease of use. However, for highly vascularized lesions such as hemangioblastomas, which contain up to capillary-level microvasculature, having access to higher-resolution intra-operative vascular imaging could potentially be highly beneficial. µDoppler-imaging is a new imaging modality especially fit for high-resolution hemodynamic imaging. Over the last decade, µDoppler-imaging has emerged as a high-resolution, contrast-free sonography-based technique which relies on High-Frame-Rate (HFR)-ultrasound and subsequent Doppler processing. In contrast to conventional millimeter-scale (Doppler) ultrasound, the µDoppler technique has a higher sensitivity to detect slow flow in the entire field-of-view which allows for unprecedented visualization of blood flow down to sub-millimeter resolution. In contrast to CEUS, µDoppler is able to image high-resolution details continuously, without being contrast bolus-dependent. Previously, our team has demonstrated the use of this technique in the context of functional brain mapping during awake brain tumor resections and surgical resections of cerebral arteriovenous malformations (AVM). However, the application of µDoppler-imaging in the context of the spinal cord has remained restricted to a handful of mostly pre-clinical animal studies. Here we describe the first application of µDoppler-imaging in the case of a patient with two thoracic spinal hemangioblastomas. We demonstrate how µDoppler is able to identify intra-operatively and with high-resolution, hemodynamic features of the lesion. In contrast to pre-operative MRA, µDoppler could identify intralesional vascular details, in real-time during the surgical procedure. Additionally, we show highly detailed post-resection images of physiological human spinal cord anatomy. Finally, we discuss the necessary future steps to push µDoppler to reach actual clinical maturity.
Integration of Polynomials Times Double Step Function in Quadrilateral Domains for XFEM Analysis
Authors: Fichera Sebastiano , Mariggiò Gregorio , Corrado Mauro , Ventura Giulio
Published: June 2023

The numerical integration of discontinuous functions is an abiding problem addressed by various authors. This subject gained even more attention in the context of the extended finite element method (XFEM), in which the exact integration of discontinuous functions is crucial to obtaining reliable results. In this scope, equivalent polynomials represent an effective method to circumvent the problem while exploiting the standard Gauss quadrature rule to exactly integrate polynomials times step function. Certain scenarios, however, might require the integration of polynomials times two step functions (i.e., problems in which branching cracks, kinking cracks or crack junctions within a single finite element occur). In this context, the use of equivalent polynomials has been investigated by the authors, and an algorithm to exactly integrate arbitrary polynomials times two Heaviside step functions in quadrilateral domains has been developed and is presented in this paper. Moreover, the algorithm has also been implemented into a software library (DD_EQP) to prove its precision and effectiveness and also the proposed method’s ease of implementation into any existing computational software or framework. The presented algorithm is the first step towards the numerical integration of an arbitrary number of discontinuities in quadrilateral domains. Both the algorithm and the library have a wide application range, in addition to fracture mechanics, from mathematical computing of complex geometric regions, to computer graphics and computational mechanics.