bluuebunny/crossref_metadata_2025 huggingface dataset:
Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling
Authors: Alarcon Vernadeth B , Marikawa Yusuke
Published: July 2022

In brief

Trophectoderm is the first tissue to differentiate in the early mammalian embryo and is essential for hatching, implantation, and placentation. This review article discusses the roles of Ras homolog family members (RHO) and RHO-associated coiled-coil containing protein kinases (ROCK) in the molecular and cellular regulation of trophectoderm formation.

The trophectoderm (TE) is the first tissue to differentiate during the preimplantation development of placental mammals. It constitutes the outer epithelial layer of the blastocyst and is responsible for hatching, uterine attachment, and placentation. Thus, its formation is the key initial step that enables the viviparity of mammals. Here, we first describe the general features of TE formation at the morphological and molecular levels. Prospective TE cells form an epithelial layer enclosing an expanding fluid-filled cavity by establishing the apical-basal cell polarity, intercellular junctions, microlumen, and osmotic gradient. A unique set of genes is expressed in TE that encode the transcription factors essential for the development of trophoblasts of the placenta upon implantation. TE-specific gene expressions are driven by the inhibition of HIPPO signaling, which is dependent on the prior establishment of the apical-basal polarity. We then discuss the specific roles of RHO and ROCK as essential regulators of TE formation. RHO and ROCK modulate the actomyosin cytoskeleton, apical-basal polarity, intercellular junctions, and HIPPO signaling, thereby orchestrating the epithelialization and gene expressions in TE. Knowledge of the molecular mechanisms underlying TE formation is crucial for assisted reproductive technologies in human and farm animals, as it provides foundation to help improve procedures for embryo handling and selection to achieve better reproductive outcomes.
МЕХАНІЗМИ КОНСТРУЮВАННЯ СОЦІАЛЬНОЇ ПАМ’ЯТІ
Authors: Hainal Tetiana Oleksandrivna , Danyliak Rostyslav Petrovych , Kuchera Iryna Vasylivna
Published: July 2022

Мета дослідження – укладення робочого переліку механізмів конструювання соціальної пам’яті та окреслення пов’язаних з цим методологічних проблем. Доведено, що такі механізми слід відрізняти від фундаментальних форм пам’яті («пам’ятання» та «забування»), факторів, що впливають на неї (наприклад, динаміка поколінь) та спеціалізованих інституцій пам’яті (музеї, освітні установи тощо). За допомогою аналізу структури процесу взаємодії суб’єкта та об’єкта отримано критерії, які дозволяють уточнити зміст поняття «механізм» у застосуванні до конструювання соціальної пам’яті. На підставі критеріїв ідентифіковано понад двадцять інструментів, що використовуються владними інституціями для формування образу минулого в груповій та індивідуальній пам’яті. На прикладі детемпоралізації, урбанізації, фальсифікації та руйнування окреслено методологічні труднощі визначення конкретних механізмів у реальних умовах їхнього застосування суб’єктами влади. Цінність дослідження полягає в тому, що конкретизація способів, якими носії влади трансформують соціальну пам’ять, перетворює їх на емпіричні показники змін. Таким чином, у сприйнятті культурних агентів «конструювання соціальної пам’яті» перестає бути лише теоретичною моделлю дослідників, а стає реальним соціокультурним процесом зі значущими наслідками.
Diferentes tipos de poda e aplicação de Cianamida Hidrogenada na produção da variedade Cabernet Sauvignon
Authors: de Freitas Fogaça Marco Aurélio
Published: July 2022

O objetivo foi avaliar a modificação da poda Royat para poda em Guyot duplo, com e sem aplicação de Cianamida hidrogenada (H2CN2), na produção da variedade Cabernet Sauvignon cultivada em espaldeira, com espaçamento de 1,25x2,5m. O delineamento utilizado foi um fatorial (2x2) inteiramente casualizado com quatro tratamentos e quatro repetições, sendo eles: dois tipos de poda (Guyot modificado e Royat) e Dormex® a 0% e 3% mais 2% de óleo mineral. Variáveis avaliadas: índice de brotação (ib), índice de fertilidade (if), número e massa de cachos.planta-1, produção.ha-1, relação área foliar - AF/massa de cacho e o teor de sólidos solúveis (0Brix). Os diferentes tipos de poda responderam as aplicações de H2CN2, propiciando aumento da AF, número e massa de cachos por planta e produção.ha-1, sem afetar o 0Brix. A H2CN2 propiciou aumento do número de brotos para poda em Guyot modificado, o índice de brotação não diferiu entre os tratamentos. A poda em Guyot modificado com aplicação de H2CN2 não diferiu da poda em Royat, quanto aos aspectos produtivos indicando ser uma opção para modificação do sistema de poda e renovação dos braços da planta.
Palavras-chave: Regulador de crescimento, Vitis vinífera L., manejo, sistema de condução.
Earth, Empire and Sacred Text: Muslims and Christians as Trustees of Creation
Authors: Johnston David L.
Published: July 2022

Earth, Empire and Sacred Text seeks to construct a Muslim-Christian theological discourse on creation and humanity that could help adherents of both faiths work together to preserve our planet, bring justice to its most needy inhabitants and contribute to peacebuilding in areas of conflict. Drawing on theology, philosophy, ethics, hermeneutics, critical theory and the social sciences, its premise is that theology is always developed in particular situations. The book explores the global context of postmodernity (the post-Cold War world dominated by a neoliberal capitalist system) and the influential turn away from the modern Cartesian view of the autonomous, disembodied self, to a self defined in discourse, community and culture (postmodernism). It traces the “career” of Q. 2:30 (Adam’s God-mandated trusteeship), first in Islamic commentaries in the classical period and then in the writings of Muslim scholars in the modern and postmodern periods. The concept of human trusteeship under God is also studied over time in Christian and Jewish writers. Building on this data, the author draws together the essential elements for a Muslim-Christian theology of human trusteeship.
Lawino in the Library: Anthropology, Modernity, and the Profession of African Literature
Authors: Burke Jordan
Published: July 2022

This essay examines the shadowy brokerage of literary and anthropological value during the era of decolonization and its connection to the institutionalizing of African literature. Drawing on original archival research, it recovers the conversation between the Ugandan poet Okot p'Bitek's major long poemSong of Lawinoand the Oxford Library of African Literature, a series of oral-literature anthologies edited by Okot's and Talal Asad's advisers at the Oxford Institute of Social Anthropology. Instead of reciprocating the series's temporal and hierarchical assumptions, which appropriate late modernist literary criticism's nostalgic veneration of the British past,Song of Lawinoreconfigures the protocols for the textual production of oral poetry by revising social anthropology's theories of time and matter. If accounts of the departmentalization of African literature portray it as a transfer of colonial paradigms to postcolonial contexts, this interfield account of the making ofSong of Lawinocalls for an alternative history.
Bibliomania and Marginalia: Unexpected Histories in the Margins of the Salisbury Library, Special Collections And Archives at Cardiff University
Authors: Tallis Lisa
Published: July 2022

This article highlights the significance of books in the personal library of Enoch Robert Gibbon Salisbury (1819–90), now the Salisbury Library at Cardiff University's Special Collections and Archives. The article outlines the research potential of the library. It considers examples
of marginalia in the collection and what these reveal about how books were read and consumed. Salisbury's personal inscriptions provide a unique and untapped insight that goes beyond the book, encompassing the histories of reading and the growth of printing in Wales, as well as the motivations
and mind-set of an astute collector. A study of these books' marginalia, authors' corrections and the revealing notes and jottings of their collector has major implications for the history of 'book culture', printing and the art of collecting in Wales.
Verbal plural allomorphy in Hunzib and its implications for the cyclicity of the morphosyntax-phonology interface
Authors: Kalin Laura
Published: July 2022

This paper investigates morphosyntactic and phonological aspects of the verbal plural in the Northeast Caucasian language Hunzib (van den Berg 1995). Verbal plural marking in Hunzib may be infixal or suffixal, and interacts in illuminating ways with morphological and phonological aspects of the verbal complex, especially with respect to establishing ordering among operations. In particular, we will see (i) that suppletive allomorphy of the verbal plural must be adjudicated at the rightmost edge of the stem, before both infixation of the infixal exponent and (morpho)phonology targeting that exponent, and (ii) that infixation of this exponent must take place after the stem of the verbal plural is fully built and has undergone a cycle of (morpho)phonology. This case study has a number of implications for modeling the morphosyntax-phonology interface, in particular, providing evidence for the precedence of exponent choice over infixation and (morpho)phonology within a cycle (Paster 2006; Bye & Svenonius 2012; Pak 2016; Kalin 2020; To appear a; Kalin & Rolle To appear; Stanton 2021, i.a.), and for bottom-up cycles in the realization of a morphosyntactic structure (Bobaljik 2000; Embick 2010; Myler 2017, i.a.).
Judging the Holy Cow: Examining the Role of Implicit Bias in Judicial Rulings – An Analysis of the Decision in Mbena v Minister of Justice and Correctional Services 2015 4 All SA 361 (ECP)
Authors: Lӧtter Casper
Published: July 2022

This contribution is an investigation into the role of implicit (as opposed to explicit) biases in judicial rulings by examining the judgment of Chetty J in Mbena v Minister of Justice and Correctional Services 2015 4 All SA 361 (ECP). Implicit bias refers to prejudice on a visceral level, namely unconscious bias, of which the bearer, to wit the judicial officer, is unaware. I suggest that exploring implicit bias in judicial rulings in the context of South Africa's harsh stigmatising shaming culture driven by incarceration as its dominant sentencing regime, will introduce a valuable window in identifying, as well as possibly illuminating and eliminating, unjustified and harmful biases. In this contribution I specifically focus against the generalised bias against ex-offenders in South Africa's harsh stigmatising shaming culture (which I distinguish from integrative shaming cultures found in Japan, China and many African societies) which attitude perpetuates the marginalisation, stigmatisation and discrimination on offenders which exceed their court-sanctioned punishment. I attempt to outline the reasons as to why the isolation and elimination of social biases of this nature are important since, in the view of many criminologists but particularly John Braithwaite, stigma is counter-productive and criminogenic as it leads to enhanced recidivism rates. To this end, I analyse the salient features of the case within a broad social context (including a consideration of phenomena such as the prison-industrial complex on South African soil) which exceeds a narrow legal framework. My roadmap for the paper encompasses a consideration of the salient, albeit disputed, facts of the case with a view towards an alternative, if plausible reading based on the probabilities of the two sets of conflicting facts presented by the opposing parties. I highlight the significance of the judgment before recommendations for improved public policy formulation are proffered.
Investigation of the Studies in the Field of Banking Risk Management via the Social Network Analysis
Authors: YILDIRIM Furkan
Published: July 2022

This study aims to examine the studies published between 2010 and 2020 in banking risk management from a bibliometric perspective and to reveal the tendencies and trends within the last decade. In this context, the bibliometric data of the studies indexed in the Web of Science Core Collection Database are obtained. The social network structure is revealed using the CiteSpace 5.5 software. According to the results of the analysis, the US-based Journal of Banking and Finance is concluded as the most frequently cited journal, where the USA has played a key role in country cooperation, and ‘management’, ‘risk’, and ‘risk management’ have been the most frequently used concepts.
BRICS-T Ülkelerinde Makroekonomik Değişkenlerin Doğrudan Yabancı Yatırımlara Etkisi: Panel Veri Analiz Uygulaması
Authors: DUMAN Erhan
Published: July 2022

Uluslararası piyasada doğrudan yabancı yatırımların özellikle gelişmekte olan ülkelerde Ar-Ge alt yapısının iyileştirilmesi, teknolojik yeniliğin sağlanması ve üretim faktörlerinde verimliliğin artırılması beklenmektedir. Bu beklenti doğrudan yabancı yatırımların hem reel hem de finansal piyasalara ait faktörler üzerinde etkili olmasından kaynaklanmaktadır. Bu çalışmada, doğrudan yabancı yatırımlar ile ekonomik büyüme, cari denge, istihdam ve reel efektif döviz kuru arasındaki ilişki BRICS-T ülkeleri dahilinde 2010:1-2021:3 dönemine ait aylık veriler kullanılarak panel veri analiz yöntemiyle incelenmiştir. İnceleme sonucunda doğrudan yabancı yatırımları etkileyen ekonomik büyüme, istihdam oranı ve reel efektif döviz kurunda öne çıkan ülke Çin iken, cari denge değişkeninde öne çıkan ülke Rusya olmuştur.
Yeni Ekonomi Sosyolojisinde Sosyal Yapı: Eleştirel Gerçekçi Bir Kritik
Authors: SOYLU Fatma Esra
Published: July 2022

Bu çalışmanın amacı; iktisat bilimini toplumla olan bağını kopardığı gerekçesiyle eleştiren ve bu bağı tekrar kurduğunu iddia eden Yeni Ekonomi Sosyolojisinin, sosyal yapı ontolojisinin yetersiz olduğunu ileri sürmektir. Yeni Ekonomi Sosyolojisinin, sosyal yapı kavramsallaştırması, kişiler arası ilişkiler olarak algılanan “sosyal ağlar” aracılığıyla açıklanmaktadır. Bu açıklama biçimi, sosyal gerçekliğin katmanlı ve tabakalaşmış yapısını göz ardı etmesi nedeniyle, analiz ampirik düzeyle sınırlanmış, indirgemeci bir analizdir. Çünkü sosyal gerçeklik yalnızca ampirik düzeyi değil reel ve aktüel düzeyleri de içermektedir. Eleştirel Gerçekçilik yaklaşımında ise sosyal yapılar, toplumda görülen olguları üreten mekanizmaların bulunduğu, sosyal gerçekliğin derin boyutunu oluşturur. Sosyal yapılar, sosyal ilişkileri ve pratikleri üreten ve ürettiklerine indirgenemeyen bir yapıdır. Bu indirgenemezlik, sosyal yapının, kişiler arası sosyal ilişkilerle veya sosyal ağlarla özdeş olmadığını gösterir. Sosyal yapılar, kişilerin eylemlerini mümkün kılan ve yine kişilerin eylemleriyle dönüştürme imkanına sahip olduğu ve ontolojik olarak kişilerden ve aralarındaki ilişkilerden/pratiklerden önce var olan yapılardır. Çalışma, iktisadi ve sosyal teori için gerekli sosyal yapı kavramsallaştırmanın, Eleştirel Gerçekçilik yaklaşımı tarafından sunulduğunu ileri sürmektedir.
Türkiye’de Bilgi ve İletişim Teknolojileri Sektörü Kapsamında Bir Girdi-Çıktı Analizi
Authors: TUNÇ Tülin , NAS Şahin , DEMİR Eylül Ece
Published: July 2022

Bilgi ve iletişim teknolojilerinin (BİT) kullanımının yaygınlaşmasıyla birlikte dünyanın bilgi çağına girdiği kabul edilmektedir. BİT üretiminin ve tüketiminin ülke ekonomilerini etkilediğinin gözlemlenmesi üzerine, bu etkiler çeşitli ampirik yöntemler ile analiz edilmeye başlanmıştır. Bu çalışmada da Dünya Girdi-Çıktı Veri Tabanından elde edilen veriler kapsamında, 2000 ve 2014 yılları için Türkiye’de, BİT sektörünün diğer sektörler üzerindeki etkisini ve dolayısıyla Türkiye ekonomisindeki yerini belirlemek üzere bir girdi-çıktı analizi uygulanmıştır. Literatürde yer alan çalışmalarda, ekonomilerde büyüme ve kalkınmaya önemli bir katkısı olduğu belirlenen BİT sektörünün, Türkiye ekonomisinde üretimdeki payının küçük olması nedeniyle katma değere ve istihdama katkısının düşük kaldığı tespit edilmiştir.
Avaliação discente do “debriefing” na simulação em semiologia médica em um curso de medicina em Salvador/BA
Authors: Pacheco Letícia Menezes , Aleluia Iêda Maria Barbosa , Sestelo Maristela Rodrigues
Published: July 2022

INTRODUÇÃO: Simulação é uma técnica utilizada para reproduzir situações do mundo real. Quando atrelada ao debriefing, este último possibilita que os estudantes realizem reflexões sobre o atendimento, tendo o professor como um facilitador do conhecimento. Neste sentido, a avaliação da técnica por parte dos alunos se faz de grande valia, possibilitando o aprimoramento do ensino e, consequentemente, das práticas na área de saúde. OBJETIVO: Avaliar o debriefing da simulação pelos alunos do curso de medicina. METODOLOGIA: Trata-se de uma análise observacional analítica/descritiva, de corte transversal, realizada nos anos de 2019 e 2020, a partir da Escala de Experiência com o debriefing aplicada a estudantes do curso de medicina de uma faculdade privada em Salvador - BA. Foram incluídos neste estudo todos os estudantes do 5º semestre de medicina do período 2019.1, que estiveram presentes no cenário “demência” da atividade de simulação do componente curricular “Semiologia Médica”. Foram excluídos, para a composição da amostra final, os questionários com preenchimento insuficiente com possível comprometimento da análise, na qual foram realizadas frequência e proporção de cada uma das quarenta variáveis. RESULTADOS: 109/110 alunos responderam de forma válida os questionários, sendo que na análise das práticas educativas através da Escala de Experiência com o Debriefing, entre 54,1 - 91,7% concordam totalmente com os vinte itens da escala e, entre 78,9 – 97,2%, afirmam a grande importância das respectivas etapas durante o debriefing. CONCLUSÃO: Os achados deste estudo demonstraram que o debriefing apresentou alta qualidade após as práticas educativas de simulação, na concepção dos acadêmicos de medicina.
Pembayaran Zakat Pendapatan Melebihi Kadar Kewajipan Zakat: Kajian dalam Kalangan Kakitangan Kerajaan di Malaysia
Authors: Nasir Siti Zulaikha , Wahid Hairunnizam , Mohd Noor Mohd Ali
Published: July 2022

Instrumen zakat memainkan peranan penting sebagai komponen dalam sistem ekonomi bagi meneraju sosioekonomi umat Islam yang lebih sejahtera di negara Malaysia di samping sistem cukai yang sedia ada. Jumlah kutipan zakat pendapatan yang meningkat saban tahun di setiap negeri disebabkan oleh pelbagai faktor termasuklah kemungkinan wujud pembayar zakat yang membayar zakat pendapatan melebihi kadar kewajipan berzakat. Namun permasalahan kajian ini ialah apakah faktor yang mempengaruhi pembayar zakat pendapatan membayar zakat pendapatan melebihi kadar kewajipan zakat. Kajian ini adalah signifikan kerana pihak institusi zakat perlu memberikan tumpuan kepada faktor tersebut dan implikasinya jumlah kutipan zakat pendapatan akan terus meningkat dengan kadar yang besar yang akhirnya akan meningkatkan manfaat agihan kepada asnaf zakat. Justeru kajian ini akan mengkaji gelagat masyarakat Islam membayar zakat pendapatan dan melebihkan pembayaran melebihi kadar kewajipan serta menganalisis persepsi masyarakat terhadap perlaksanaan sistem zakat dan cukai di Malaysia. Kajian ini menggunakan analisis secara deskriptif ke atas ujian skor min, analisis Alpha Cronbach dan perbezaan nilai GAP min ke atas responden penjawat awam di Jabatan Agama Islam Melaka (JAIM). Hasil kajian menunjukkan kadar nisbah zakat yang dibayar melebihi kadar kewajipan adalah pada kadar 0.4 lebih daripada kewajipan zakat yang sepatutnya yang berupaya memberi sumbangan sebanyak 21 peratus daripada keseluruhan kutipan zakat di negeri Melaka. Menariknya, kajian mendapati tindakan ini didorong oleh faktor agama dan faktor nilai altruisme yang signifikan mempengaruhi gelagat pembayar zakat. Selain itu, hasil kajian menunjukkan responden lebih berpuas hati dengan maklumat serta perlaksaan sistem zakat berbanding cukai. Beberapa cadangan dan implikasi dasar turut dibincangkan dalam kajian ini.
Current opportunities for the export of medical services in Russia
Authors: Russkikh S. V. , Tarasenko E. A. , Grin S. I. , Yugay M. T. , Kryukova K. K. , Moskvicheva L. I.
Published: July 2022

Objective: to identify factors and barriers for the development of medical services export (MSE) in the Russian Federation (RF), to establish recommendations for its stimulation, and to promote Russia as an exporter of medical services in the international arena.

Material and methods. An analysis of the practice of MSE organizing and regulatory documents of 2018–2021 was carried out, as well as the quantitative sociological survey of 184 doctors, healthcare managers and experts and the in-depth semi-structured interviews with 8 high-level healthcare experts conducted in 2020. The survey was performed using the “snowball” method. To increase the level of representativeness of the survey results, doctors, organizers and healthcare experts with current work experience in organizations and government bodies in the healthcare sector (Ministry of Health of the RF, Roszdravnadzor, Central Research Institute of Organization and Informatization of Public Health, etc.) were involved as respondents including practicing physicians and heads of medical organizations.

Results. The aim of MSE state regulation and stimulation is to choose the optimal model for supporting inbound medical tourism (IMT) in the RF. At the moment, three models of supporting foreign citizens in the medical services market are developing: 1) creating expert medical consortia of leading medical clinics; 2) forming an infrastructure for agency support in the Russian IMT market, including the development of infrastructure in regional IMT markets with high, medium and low export potential; 3) paid medical services in all types of medical care are successfully provided in public and private clinics to foreign citizens who live, work or study in the RF on a permanent or temporary basis. The third model is а self-organizing patient flow of foreign citizens, uncontrolled by Russian medical organizations.

Conclusion. The main strategic directions of MSE development for the growth of an organized and controlled patient flow in the RF are medical care services in the field of neurosciences, high-tech surgery and rehabilitation, reproductive medicine, immunotherapy of oncological diseases, and cross-border diagnostic services. It is necessary to take certain measures to stimulate MSE, including the introduction of international standards for the safety and quality of medical care, increasing the service component of the provision of medical services, building channels of marketing communications with foreign patients and the promotion of Russia as an exporter of medical services in the international arena.
Pharmacotherapy of insomnia in childhood
Authors: Tadtaeva Z. G. , Galustyan A. N. , Rusanovsky V. V. , Gromova O. A. , Sardaryan I. S. , Krivdina M. Yu. , Kuritsyna N. A.
Published: July 2022

Insomnia is the most common form of sleep disturbance in childhood. Sleep disorders and a decrease in its duration and quality lead to the development of cognitive disorders, change emotional and behavioral functions of the developing organism, and negatively affect medical and psychological aspects that require medical correction. The article provides an overview of current literature data on pharmacological approaches to insomnia therapy in childhood. The general principles of treatment and the use of various pharmacological groups of drugs are discussed. It is shown that pharmacotherapy of childhood insomnia should be carried out based on knowledge about the age characteristics of patients, efficacy, safety, analysis of pharmacodynamic and pharmacokinetic parameters of the drugs used. Drug therapy should be combined with cognitive behavioral techniques, including adherence to sleep patterns and hygiene.
Strengthening medical rehabilitation services in health system: a situation analysis
Authors: Blinov D. V. , Solopova A. G. , Sandzhieva L. N. , Achkasov E. E. , Korabelnikov D. I. , Ampilogova D. M. , Khlopkova S. M.
Published: July 2022

Objective: to evaluate the effectiveness of changes in the legal framework that regulates medical rehabilitation (MR) in the Russian Federation.

Material and methods. We analyzed the valid Order of the Ministry of Health of the Russian Federation of June 31, 2020 No. 788n “Organization of medical rehabilitation of adults”, which came into legal power on January 1, 2021. It was proposed for public discussion on the introduction of amendments (project of amendments). The changes proposed in the project were compared with the original text of the document. Besides, other legal documents on the organization of medical rehabilitation were analyzed.

Results. Order No. 788n regulates the stages of MR, specifies the formation and realization of an individual plan for a multi-disciplinary rehabilitation team based on the evaluation by Rehabilitation Routing Scale. The document includes in-house protocols of profile inpatient and outpatient departments of medical institutions, standards for doctor’s offices equipment, organization of day-time inpatient department, and regulations for MR centers. The project of amendments contains a variant of involvement of the existing additional Groups 1 and 2 medical divisions for the organization of MR, and limitation for the Stage 2 of MR in inpatient settings, which is now possible only for patients who need 24-hour care.

Conclusion. The proposed changes have evolutionary character. A lot of issues in the regulatory framework of MR remain unsolved. It is necessary to improve the state policy for MR and perform further clinical studies of its benefits.
Epigenetic aspects in rehabilitation of female cancer patients
Authors: Solopova A. G. , Blinov D. V. , Demyanov S. V. , Demyanov G. V. , Achkasov E. E. , Vlasina A. Yu. , Sandzhieva L. N. , Ampilogova D. M.
Published: July 2022

The influence of epigenetic processes on the development of malignant diseases, including gynaecological cancers, is now beyond doubt. DNA methylation, histone modification and post-transcriptional regulation by microRNAs lead to changes in the activity of various genes, contributing to female genital cancers (cervix, endometrium, ovarian). It should be noted that disruptions in gene expression do not only occur in malignant cells, but also in the tumour microenvironment, resulting in disease progression and relapse. However, “epigenetic markers” of carcinogenesis can be useful in the treatment and rehabilitation of patients, making a personalized approach possible.
The Study of High-Level Virtual Reality and Personality Creativity
Authors: Anikina V.G. , Khoze E.G. , Strizhova I.V.
Published: July 2022

The study examined the impact of the highest level of VR — the use of VIVE helmets — on individual creativity. Before and after working with VR programs using VIVE helmets, the participants in the study (n=28) were diagnosed with the parameters of verbal creativity: sensitivity to the problem, preference for complexity fluency, flexibility, resourcefulness, ingenuity, imagination, ability to structure, originality, resourcefulness and productivity, independence, originality, confident style of behavior; non-verbal creativity: originality, uniqueness; as well as general creativity. As a result of statistical data processing, it was shown that the study participants experienced significant changes in non-verbal creativity indicators — “originality” (at p ≤0.05) and “uniqueness” (at p ≤0.01). The vectors for further research on the problem of the connection between creative activity, creativity of the individual and virtual reality are determined.
Psychological Model of the Process of Perception of Virtual Objects by Preschoolers
Authors: Krylova S.G. , Vodyakha Y.E.
Published: July 2022

The study of children’s perception of computer models of objects (virtual objects), as different from objects of the physical world in their characteristics, is a urgent problem, but poorly researched. The goal of research is to develop a psychological model of the process of perception and recognition by preschoolers of a virtual 3D object when performing actions with it on the iPad screen. The developed model is empirically verified and makes it possible to explain the results obtained in the experiment to study the differences in the recognition of a virtual 3D object and its real prototype after perception under conditions of unimodal (visual, haptic) and bimodal (visual-haptic) perception. The experiment involved 115 preschool children (4—6 years old), divided into 5 randomized groups. It was found that during haptic recognition of a previously presented virtual object, children significantly more often chose a distractor figure that had the same dimension as the original object, but differed from it in the absence of shape details (φ * emp = 1.697, p <0.05). These results are explained by the specifics of the nature of interaction with virtual objects on the iPad screen (impact on the object without direct contact with it), as well as the discrepancy between expectations based on the experience of interacting with real objects.
Spectral Characteristics of the EEG Theta-Band and Efficiency of Cognitive Test “N-Back” Performing
Authors: Karatygin N.A. , Korobeinikova I.I. , Venerina Y.A. , Venerin A.A. , Alexandrov Y.I.
Published: July 2022

Effectiveness of cognitive test “n-back” performing was assessed in 32 subjects, right-handed men, 18—21 years old. EGG was recorded monopolarly in “10—20” system during initial state, in the period after the first learning stage and during the second learning stage while the subjects performed the test on their own. Two groups of subjects were marked, basing on differences between efficiency of their cognitive activity. Spectral analysis revealed none differences in theta-band spectral power between subjects of the two groups at the initial state. Successful subjects demonstrated increase of the theta-band spectral power in occipital, parietal, central and left frontal zones of cortex in the period after the first learning stage comparing to unsuccessful subjects. On the contrary, unsuccessful subjects demonstrated significant increase of the theta-band spectral power in the second learning stage during the test self-performing comparing to the initial state and the period after the first learning stage. Increase of spectral power of the theta-band can be considered as a regression stage of systemogenesis, accompanied by increase of the representation of low-differentiated systems in new behavior realization and causing high efficiency of cognitive activity.
Non-Verbal Languages of Consciousness: Representation of Subjective Attitude through Color, Form and Direct Assessment
Authors: Akopov G.V. , Akopyan L.S. , Belous A.V. , Kaptsov A.V.
Published: July 2022

Since the end of the last century, the problem of consciousness has come to the fore in the world science. The unresolved nature of this problem until today is connected with the insurmountability of the “border” between phenomenal and psychological (cognitive) consciousness. One of the directions for solving this problem is connected with the provision on the existence of different languages of consciousness in the context of the idea of a categorical system of representative consciousness. The article presents work on the design and empirical comparison of fixed means of representing personal (subjective) relationships as certain forms of phenomenal cognitive consciousness. The interrelation and interdependence of the categories “representation” and “attitude” is fixed, the first of which (representation) is fundamental in many programs for solving the so-called difficult problem (“Hard Problem”) in English-language studies; the category “attitude” is comparable to it in terms of significance for the problem of consciousness in Russian psychology. It is assumed that sensory-perceptual consciousness (qualia) can be represented both by verbal and color-associative, as well as by associative-geometric means on the target objects of subjective attitude. Methods used: color test of relationships, adapted to the objectives of the study; geometric test of relationships in authoring; the scale of value judgments in relation to social and personally significant objects; the author’s method of determining the characteristics of the internal communication of a person. The equivalence of the contents of phenomenal cognitive representations in evaluative dimensions is shown empirically. The interpretation is based on the proposition of the existence of verbal and non-verbal (sign) languages of consciousness, which are not always amenable to “translation” into verbal language. It has been proven that in most cases the non-verbal representation of subjective attitudes towards social and personally significant objects through color and geometric associations in most cases is accompanied by processes of internal communication.
Assessing the Pilot Condition According to Video Oculography Data and Parameters of Brain Alpha Rhythms by Modeling the Neural Activity
Authors: Kuravsky L.S. , Yuryev G.A. , Greshnikov I.I. , Zlatomrezhev V.I. , Polyakov B.Y. , Orlova S.I. , Yuryeva N.E.
Published: July 2022

The H.R. Wilson and J.D. Cowan model of human brain neural activity is considered, which connects the latent (non-measurable) parameters of external excitation with the brain neuronal activity parameters which are available for observation, with alpha rhythm frequencies being in use in this capacity. By means of computational experiments, revealed are the ranges of latent parameters, which ensure the occurrence of the Poincaré—Andronov—Hopf bifurcation (transforming the spiral sink to the spiral source equilibrium point with a limit cycle, or vice versa) that leads, in the first approximation, to the appearance of alpha rhythms. Relative changes of the latent parameters representing external excitation are estimated through the primary indices of oculomotor activity (gaze movement entropies and gaze fixation durations), which makes it possible to assess the pilot proximity to falling into a low efficiency state, including the real time mode.
Parasitic Element Based Frequency Reconfigurable Antenna with Dual Wideband Characteristics for Wireless Applications
Authors: Boyapati Bharathidevi , Kumar Jayendra
Published: July 2022

A Microstrip Frequency Reconfigurable circular patch slot antenna for switchable Bluetooth, WiMAX, WLAN, and satellite communication applications is analyzed and presented in this work. The optimized overall size of 47 mm x40 mmx1.6 mm is utilized in the design, and which can cover wide range of frequencies below 10 GHz. In the initial phase, different monopole antennas are designed with various shapes of same size and later parasitic patch elements has been added to those monopole antennas. The circular monopole driven element and parasitic element are connected with a PIN diode, and which reinforced in achieving frequency reconfigurability. The proposed antenna is resonating at various frequencies of 2.4 GHz, 4 GHz, and 8.4 GHz when the diode in ON condition and resonating at 3 GHz, 5.4 GHz, and 8.4 GHz when the diode is in OFF condition. The performance of the designed antenna prototype is scaled and differentiated with the results of simulation and found good matching with respect to performance characteristics.
Wonder, beauty, ability and the natural world: The experience of wonder as a positive aesthetic emotion in Old English verse
Authors: Minaya Gómez Francisco Javier
Published: July 2022

Drawing on the recent studies on aesthetic emotions and on their recent application to the field of the Old English aesthetic emotions, this paper explores one emotion from the emotion family of AMAZEMENT in the Old English poetic corpus, attending to the type of wonder that is typically triggered by objects of beauty, excellent manufacture and by the natural world. The purpose of this paper is to understand better the poetic usage of the Old English terms for wonder as well as evidence their role in literary and everyday contexts. Through a fine-grained analysis of the above domains, this paper has shown that the wonder implicit in these texts can be triggered by perceptual or cognitive appraisals, but also by a combination of both, highlighting the complexities and particularities of the early medieval English emotion of WONDER, as well as its similarity to other emotions like the EXPERIENCE OF BEAUTY or AWE.
From lexical collation to significant omissions and paraphrases: New evidence for refining relations within the Prick of Conscience Group-IV Manuscripts
Authors: Garrido Edurne
Published: July 2022

Abstract: The Prick of Conscience is known to have survived in 97 manuscripts of the Main Version, 19

of the Southern Recension, and about 50 short extracts. An initial collation of one lexical item in the 97

extant copies of the Main Version and subsequent comparison of another 109 items in 54 of these copies

allow for identifying parallel variant readings throughout the poem’s almost 10,000 lines. Those variants

often transcend the word level affecting the line, the couplet, or more extensive passages. This paper

contributes to refining textual relations within the Group-IV family of the work by showing distinct

variance common to Dublin, Trinity College, 157 (D.4.11) (MV 21), London, Sion College, Arc. L. 40.

2/E. 25 (MV 49), and Shrewsbury, School, III (Mus. III. 39) (MV 95). Apart from unfolding and expanding

the extent of the relationship pointed out by Lewis & McIntosh (1982), this research also proves that the

hitherto unsubclassified London, Lambeth Palace, 492 (MV 48) is another member of the subgroup. To

illustrate how the proposed subset relates to a version closer to the presumed original and other Group-IV

witnesses, readings from the following London, British Library manuscripts are also provided for reference:

Cotton Galba E. IX (MV 27); Harley 4196 (MV 34); Egerton 657 (MV 29); Additional 22283 (MV 40).
Lichen planus and itch-related psychosomatic disorders
Authors: Dorozhenok Igor Yu. , Snarskaya Elena S. , Mikhailova Mariana
Published: July 2022

BACKGROUND: The relevance of studying psychosomatic disorders associated with itching in patients with lichen planus (LP) is due to a wide range of transnosological comorbidity of nosogenic and depressive disorders with clinical phenotypes of LP.
AIMS: Clinical verification and typological differentiation of psychosomatic disorders associated with itching in accordance with the LP phenotypes we identified in patients of the studied sample.
MATERIALS AND METHODS: 120 patients (77 women and 43 men, average age 47.65.2 years) with various LP phenotypes and comorbid psychosomatic disorders associated with itching were examined. Dermatological, using the modern lichen planus area and severity index (LPASI); questionnaire of the severity of itching (behavioral rating scores, BRS), the dermatological quality of life index (DQLI) questionnaire; psychopathological, using the Hospital Anxiety and Depression Scale (HADS); clinical-psychological.
RESULTS: Psychosomatic disorders associated with itching were identified and typologically differentiated in patients with lichen planus: nosogenic reactions that develop in response to manifestations of a skin disease (depressive, sociophobic, beauty hypochondria), as well as recurrent depression. For each type of psychosomatic disorders, different ratios of dermatological and psychosomatic symptoms have been identified. Nosogenic reactions that develop within the considered ratios are comparable to nosogenies in severe somatic diseases and are clinically manifested by anxiety and depressive disorders. In other cases, the key trigger is not the severity of the dermatosis, as in nosogenic depression, but the cosmetically significant localization of the rash. These psychosomatic disorders are represented by sociophobic nosogenic reactions, as well as beauty hypochondria nosogenies, in the formation of which constitutionally determined somatoperceptual accentuations with deformation of the body image make a significant contribution.The role of constitutional factors and somatoperceptive accentuations is determined. The structure of amplified pruritus was analyzed, including the stressful impact of the SARS-CoV-2 pandemic. Methods of effective therapy based on an integrated interdisciplinary approach are presented.
CONCLUSION: Effective diagnosis and treatment of psychosomatic disorders associated with itching contribute to a significant optimization of the course of LP and improve the quality of life of patients.
Efficacy of cooling-vacuum assisted 1540 nm erbium-doped glass laser (Er:Glass) in mild-to-moderate acne
Authors: Pinson Igor Ya. , Verchoglyad Irina V. , Anpilogova Ekaterina M.
Published: July 2022

BACKGROUND: Acne is a common skin disease that affects millions of people around the world. There are several options for acne treatment: the application of local anti-acne agents often has limited effectiveness, and systemic treatment carries the risk of significant side effects. Sources of visible, infrared and laser radiation have become common physical methods of treating acne.
AIMS: to evaluate the effectiveness and safety of an erbium laser on glass (1540 nm) with integrated cooling and vacuum amplification for the treatment of mild-to-moderate acne
MATERIALS AND METHODS: We observed twelve patients (seven men and five women) from 17 to 27 years old (average age 191.6) with Fitzpatrick skin type II to IV. Acne severity was assessed using the Investigators Assessment Scale (IGA). 5 patients had mild acne (IGA 2) and 7 had moderate acne (IGA 3). Patients were treated with an erbium laser on glass using the mid-infrared region of the spectrum, with a wavelength of 1540 nm (Harmony XL, Alma Lasers Ltd.), 4 to 6 procedures were performed every 2 weeks. The number of sessions was determined by clinical improvement.
RESULTS: All 12 patients completed treatment (from four to six procedures, mean value 4.60.4) and were observed 1 and 3 months after the last session. The improvement in the appearance of the skin occurred gradually. Clear (IGA 0) or almost clear (IGA 1) skin were achieved in all patients. The subjective assessment of patient satisfaction ranged from satisfied (four patients) to very satisfied (eight patients) during the last visit. Side effects were mild and included mild erythema and edema in all patients, their severity and the percentage of patients suffering from them decreased during treatment. No edema was observed during follow-up visits after 1 and 3 months.
CONCLUSIONS: The study proves the effectiveness and safety of the cooling-vacuum assisted 1540 nm erbium-doped glass laser (Er:Glass) in mild-to-moderate acne. Further studies with a larger number of participants and a longer follow-up period are needed to establish long-term efficacy.
Development of cutaneous sarcoidosis to permanent eyebrow makeup procedure
Authors: Snarskaya Elena S. , Tavitova Alana R. , Bratkovskaya Anna V. , Semko Nika S.
Published: July 2022

The article summarizes the data on historical aspects, epidemiology, etiopathogenesis, clinical picture, diagnosis and treatment of skin sarcoidosis. Sarcoidosis is a chronic multisystem disease from the group of granulomatoses of unknown etiology, the morphological feature of which is the development of epithelioid cell granulomas without caseous necrosis with the processes of dystrophy, destruction and fibrosis in the tissues of various organs. Diagnosis and differential diagnosis of sarcoidosis are based on clinical examination, changes in laboratory data, X-ray methods and skin biopsy. The differential diagnosis includes many dermatoses, including tuberculoid type of leprosy, tuberculous lupus, lichen planus, annular granuloma, etc. In the treatment of sarcoidosis of the skin, corticosteroid drugs are used, including prolonged action. In case of resistance or contraindications, synthetic antimalarial and immunosuppressive agents are prescribed.
According to the literature, cases of granulomatous reactions after permanent makeup procedures have become more frequent. The tattoo procedure is widespread and considered to be safe, but adverse reactions, particularly sarcoidosis of the skin, may develop.
The etiology of sarcoidosis has been studied for more than 150 years and remains poorly understood until now. There are increasingly frequent reports in the literature about the development of immune granulomatous inflammation reactions after a numerous of cosmetic procedures, such as tattooing, botulinum toxin A injection, hyaluronic acid injections, permanent makeup, biorevitalization, facial modeling fillers, blepharoplasty. The increasing number of cases of skin sarcoidosis due to cosmetological manipulations is the subject of great scientific interest, and the growth of publications on this topic is an evidence of modern etiopathogenetic mechanisms of the disease development.
Here is our clinical observation of skin sarcoidosis without systemic manifestations in a 54-year-old patient after permanent eyebrows make-up procedure outside the medical organization, without prior examination and lack of follow-up (the skin process is subacute; polymorphism of the rash is noted; rashes on the skin in the eyebrow area are represented by merging papules, foci correspond to the area of pigment injection). According to the results of physical, laboratory and instrumental studies, many epithelioid cell granulomas without caseous necrosis were found. The patient received a course of intraocular pricking with a prolonged glucocorticoid drug (Betamethasone suspension, No. 5), which led to a complete regression of rashes. Recommendations for the removal of pigment are given.
In order to prevent infection and minimize the risks of complications, a high level of qualification of a dermatocosmetologist working in a specialized medical institution is a prerequisite for permanent makeup.
Photogallery of clinical cases from the international contest of professor Marc Larregue 2021 (organized by Uriage Laboratory, France)
Authors: Olisova Olga Yu. , Lonescu Marius-Anton
Published: July 2022

In summer 2021, an international contest of best clinical photos of professor Marc Larregue for dermatologists was organized by Uriage Laboratory France (http://collectionmarclarregue.fr). Dozens of doctors took part in this contest and the jury consisted of leading experts. New clinical photos submission to professor Marc Larregues contest 2022 will be opened soon. Detailed information and further instructions you can find on the official website http://collectionmarclarregue fr.
We publish winners clinical photos and the most interesting cases with the permission of contests organizers. Each photo entered in the competition was taken after obtaining informed consent from each patient.
Analisis Pembelajaran Kooperatif Tipe Word Square Untuk Meningkatkan Hasil Belajar Siswa Pada Muatan Pelajaran IPS di Sekolah Dasar
Authors: Basar, Arifin Maksum, Andi Arif Saladin Zulfa Rahmani
Published: July 2022

Penelitian ini merupakan penelitian studi pustaka yang bertujuan untuk mengkaji informasi mengenai pembelajaran kooperatif tipe Word Square untuk meningkatkan hasil belajar siswa pada muatan pelajaran IPS di Sekolah Dasar. Penelitian ini dilaksanakan pada bulan April-Juni 2021. Metode yang digunakan pada penelitian ini adalah metode kualitatif deskriptif dengan teknik analisis data model Miles dan Huberman. Model Miles dan Huberman memiliki empat tahapan yaitu pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Berdasarkan sumber data yang telah dianalisis, hasil penelitian menunjukkan bahwa pembelajaran kooperatif tipe Word Square dapat digunakan sebagai metode alternatif untuk meningkatkan hasil belajar siswa pada muatan pelajaran IPS di Sekolah Dasar.