bluuebunny/crossref_metadata_2025 huggingface dataset:
Abnormal thyroid function: an unusual presentation of pituitary stalk interruption syndrome
Authors: Steen Erica A , Patterson Mary E , Rivera-Vega Michelle , Phillips Susan A
Published: May 2023

An 11-year-old girl with past medical history of septic shock and multi-organ failure at age 5 presented to her primary care doctor with concern for pallor of the lips. Laboratory studies demonstrated low free thyroxine (T4) and normal thyroid-stimulating hormone (TSH). A referral to endocrinology was made where the patient was evaluated, and laboratory evaluation was repeated. The patient was asymptomatic and clinically euthyroid with a height consistent with her mid-parental height and was in mid- to late-puberty. The repeated laboratory evaluation demonstrated a pattern suggestive of primary hypothyroidism with low free T4 and an elevated TSH. However, the magnitude of elevation of TSH was less than expected, given the degree of lowering of free T4; therefore, central hypothyroidism was considered. Workup was initiated, and laboratory studies and MRI imaging confirmed an underlying diagnosis of panhypopituitarism in the setting of pituitary stalk interruption syndrome.

Learning points

Pituitary stalk interruption syndrome is a rare but important cause of panhypopituitarism.

Central hypothyroidism should be suspected in patients with low free thyroxine with an inappropriate degree of elevation of thyroid-stimulating hormone.

Workup of central hypothyroidism should include multi-pituitary hormone assessment, and, if evident, MRI imaging should be done.

Adrenal insufficiency should be suspected in a hypotensive, critically ill patient who is failing to improve on standard-of-care therapy.
Silent intrathyroid parathyroid carcinoma
Authors: Kim Ekaterina , Bondarenko Ekaterina , Eremkina Anna , Nikiforovich Petr , Mokrysheva Natalia
Published: May 2023

A 59-year-old male presented with an accidental thyroid mass in 2022. Ultrasound and CT scan showed a nodule 5.2 × 4.9 × 2.8 cm (EU-TIRADS 4) in the right lobe of the thyroid gland. Taking into account the results of the fine needle aspiration biopsy (Bethesda V), intrathyroid localization, and absence of clinical symptoms, a malignant tumor of the thyroid gland was suspected. The patient underwent total thyroidectomy using fluorescence angiography with indocyanine green, and two pairs of intact parathyroid glands were visualized in typical localization. Unexpected histological and immunohistochemistry examinations revealed parathyroid carcinoma. Due to the asymptomatic course of the disease and atypical localization of parathyroid tumor, primary hyperparathyroidism was not suspected before the surgery. The diagnosis of asymptomatic intrathyroid parathyroid cancer is a serious diagnostic challenge for a wide range of specialists.

Learning points

Parathyroid cancer is a rare disease that may be asymptomatic.

Intrathyroidal localization of parathyroid carcinoma is casuistic and challenging for diagnosis, and the treatment strategy is not well defined.

Preoperative parathyroid hormone and serum calcium testing are recommended for patients with solid thyroid nodules (Bethesda IV–V).
Second primary cancers and survival among neuroendocrine tumor patients
Authors: Bateni Sarah B , Coburn Natalie G , Law Calvin , Singh Simron , Myrehaug Sten , Assal Angela , Hallet Julie
Published: May 2023

There is an increased risk of second primary cancers (SPCs) after neuroendocrine tumor (NET) diagnosis. The clinical significance of SPCs in this population is unknown. The purpose of this study was to evaluate the association between SPCs after NET diagnosis and survival. We performed a population-based, retrospective cohort study of NET patients (gastrointestinal, pancreatic, or lung primary) from 2000 to 2016 using the Surveillance, Epidemiology, and End Results database. Cox regression models assessed the association between SPCs and NET-specific (NET-SS), cancer-specific (CSS), and overall survival (OS). Of 58,553 NET patients, 7.9% experienced an SPC. SPCs were associated with worse OS (hazard ratio (HR) 2.14, 95% CI 1.94–2.36) and CSS (HR 2.31, 95% CI 2.06–2.59) with no difference in NET-SS (HR 1.04, 95% CI 0.87–1.23). Stratified analyses by histologic grade showed similar results for well and moderately differentiated NETs, but no difference in OS or CSS for poorly differentiated NETs (P > 0.05). In stratified analyses by NET site, SPCs were associated with worse OS (HR 3.41, 95% CI 3.01–3.87) and CSS (HR 4.96, 95% CI 4.28–5.74) in gastrointestinal NETs and worse OS (HR 1.25, 95% CI 1.03–1.52) with no difference in CSS (HR 1.08, 95% CI 0.85–1.36) in lung NETs. SPCs were not associated with a difference in OS or CSS in pancreatic NETs (P > 0.05). In conclusion, SPCs after NETs were associated with inferior OS and CSS compared to no SPC but were not associated with NET-SS. These data highlight the need for long-term follow-up in NETs to include the detection of SPCs to ensure early diagnosis and timely management.
BRAFV600E restructures cellular lactylation to promote anaplastic thyroid cancer proliferation
Authors: Wang Xumeng , Ying Tianxing , Yuan Jimeng , Wang Yue , Su Xingyun , Chen Shitu , Zhao Yurong , Zhao Yuanyuan , Sheng Jinghao , Teng Lisong , Luo Chi , Wang Weibin
Published: May 2023

Anaplastic thyroid cancer (ATC) is a rare but fatal cancer with BRAF mutation ranging from 30 to 50%. Histone lysine lactylation represents a novel epigenetic mark that translates cellular metabolic signals into transcriptional regulation. It is not clear whether the Warburg effect can promote the proliferation of ATC with BRAFV600E mutation via metabolite-mediated histone lactylation. Our study aimed at illustrating how BRAFV600E restructures the cellular protein lactylation landscape to boost ATC proliferation, and determining whether blockade of protein lactylation can sensitize mutant ATC to BRAFV600E inhibitors. Western blotting was used to evaluate lactylation status. Aerobic glycolysis was intervened by adding cell-permeable ethyl lactate or using metabolic inhibitors. Chromatin immunoprecipitation and RT-qPCR were applied to analyze the expression of growth-related genes. Different chemical inhibitors were used to inhibit BRAFV600E and other enzymes. ATC cell line-derived xenograft model was employed to examine the efficacy of mono and combinatorial therapies. The results showed that aerobic glycolysis in ATC increased global protein lactylation via improving cellular lactate availability. In particular, lactylation on Histone 4 Lysine 12 residue (H4K12La) activated the expression of multiple genes essential for ATC proliferation. Furthermore, oncogenic BRAFV600E boosted glycolytic flux to restructure the cellular lactylation landscape, leading to H4K12La-driven gene transcription and cell cycle deregulation. Accordingly, the blockade of cellular lactylation machinery synergized with BRAFV600E inhibitor to impair ATC progression both in vitro and in vivo. Our results demonstrated an extra beneficial effect of aerobic glycolysis on ATC, revealing a novel metabolism-epigenetics axis suitable for combinatorial therapy with BRAFV600E inhibition.
PROBLEMS OF APPLYING LEGAL TECHNIQUES AND TERMINOLOGY IN ECONOMIC AND ECONOMIC PROCEDURAL LEGISLATION OF UKRAINE
Authors:   Taras Shevchenko National University of Kyiv, Shcherbyna V.S.
Published: May 2023

The article examines the problems of applying legal techniques and terminology in some legal acts of economic and economic procedural legislation. Attention is drawn to the shortcomings, contradictions and inconsistencies of the provisions of individual norms of the specified legal acts, the cause of which is non-compliance with the rules of legal technique and the unsuccessful use of legal terms. In addition, the inconsistency of the terms with the legal concepts that take place in economic legislation consists in not taking into account (not reflecting) the content of the corresponding legal concept and the absence of systematic logical connections between the terms. Four main variants of anomalies in the application of terms in the economic legislation of Ukraine are highlighted: the use of terms that do not reflect the content of legal concepts; the use of the same term to designate legal concepts different in content; the use of different terms to name legal concepts that are identical in content; the use of other terms in the normative-legal acts of the current economic legislation, including those contrary to the terms of the Economic Code of Ukraine. It is noted that certain shortcomings are inherent not only in the current laws, but also in the draft laws under consideration in the Verkhovna Rada of Ukraine. As an example, the draft Law of Ukraine “On the peculiarities of regulation of entrepreneurial activity of certain types of legal entities and their associations in the transition period” is given. The shortcomings of legal technique and legal terminology in the Economic Procedural Code of Ukraine are analyzed. It is claimed that the presence of deficiencies in economic and economic procedural legislation, which are revealed in the process of law enforcement, indicates an inappropriate level of application of legal techniques and terminology at the stage of development and adoption of regulatory legal acts by the competent state bodies, which undoubtedly harms their law enforcement and to some extent discredits the legal system of Ukraine.
ACTIVITIES OF BAR OFFICES AND BAR ASSOCIATIONS AS ECONOMIC ACTIVITY
Authors:   National University “Chernihiv Polytechnic”, Apanasenko K.I. , Stechenko K.L. ,   National University “Chernihiv Polytechnic”
Published: May 2023

The Law of Ukraine “On the Bar and Legal Practice” provides for the functioning of bar office and bar associations as organizational forms of attorney legal practice. At the same time, the legal status of these subjects needs to be determined from the point of view of possible belonging to a circle of economic subjects. Issues of the legal status of law firms and law associations are discussed in research of V.M. Bogoslavets, O.O. Jaburiya, K.A. Zatulko and M.E. Kiselyov, Yu.M. Yurkevich and others. They considered the issue of the possible belonging of specified legal entities to the number of economic entities, analyzed their organizational and legal form. We believe that conclusions about the nature of their activities are decisive for the assertion that legal entities belong to the circle of economic entities. The analysis of the activities of bar offices and bar associations from the point of view of its possible qualification as an economic activity according to the existing legal regulation was the main task of the authors of the publication. During the research, it was found that bar offices, bar associations provide services, and perform work for a fee based on contracts on the provision of legal assistance. Such activity ensures the satisfaction of the private interests of these legal entities in profit and, at the same time, the implementation of important public interests in providing legal assistance to a wide range of individuals and legal entities. The activity of bar offices and bar associations is the activity of professional entities endowed with rights and obligations identical to the rights and obligations of economic entities. Under such conditions, it is logical to conclude that bar offices (associations) have the status of economic entities. The conducted research confirmed the presence of features of entrepreneurial companies in the understanding of this concept by the Civil Code of Ukraine in bar offices and bar associations. In the future, it is worth finalizing the issue of the specific organizational and legal form of these entities and enshrining the relevant provision in the Law of Ukraine “On the Bar and Legal Practice”.
Technological trends & software engineering education: a systematic review study
Authors:   International European University, O.V. Nesterenko O.V.
Published: May 2023

The quality of software engineering education is influenced by the consideration of modern industrial trends, IT trends and software development methodologies. The transition to a new level of industry - “Industry 4.0”, characterized by robotics and cyber-socialization, brings a wave of new, never-before-seen challenges to the field of IT and programming. Under such conditions, it is impos- sible to achieve the desired synergistic effect without the formation of an appropriate informational and educational environment in institutions of higher education. One of the sources of the content of such an environment can be the publications of the world scientific community registered in international scientometric databases. On this basis, it becomes possible not only to provide effective digital educational content, but also to choose and use the latest technological means of learning support. A targeted review of primary sources in the Web of Science Core Collection database made it possible to identify, select, synthesize and evaluate research evidence relevant to the research questions: (i) what technological trends are analyzed in research, (ii) what information technolo- gies are considered in research, (iii) what strategies are reflected in publications to overcome the above challenges of SE teaching and learning. According to the results of the study, we offer to improve the educational and methodological support of software engineering education based on ontological modeling of the integration of the requirements of modern trends in the development of the industry and the IT sector, international recommendations and the capabilities of technological teaching aids. This approach is a good basis for the processes of intellectualization of information systems of the educational environment and the construction of appropriate technological educational tools on their basis.
Boyko Ontological system processing of databases of scientific publications
Authors:   Glushkov Institute of Cybernetics NAS of Ukraine, Palagin O.V. , Petrenko N.G. ,   Glushkov Institute of Cybernetics NAS of Ukraine, Boyko M.O. ,   Glushkov Institute of Cybernetics NAS of Ukraine
Published: May 2023

Development of theories, methods and algorithms for the discovery and formation of new knowledge always was one of the most important tasks for any researcher, especially if they actively working on creation of new scientific publications. There is no universal language to describe formally concepts (knowledge) and systemology of transdisciplinary scientific research. Because of this, researchers have a set of urgent problems, and one of them is the way of speeding up the process of finding information (in the form of cognitive-structure) in their own sources. Ontological system for processing of databases of scientific publications created to solve this problem for a researcher, who have from tens to hundreds of scientific papers published. We are unaware of search systems, which would provide the same information for a researcher in such a short time. Ontological system implements technologies of Information Retrieval and Knowledge Discovery in Databases with accent on technologies and instruments such as Semantic Web and cognitive graphics. Development of such ontological system have three stages. On the first stage instruments for system development created, methods and algorithms of interaction between system components "User ¾ Knowledge engineer ¾ Remote endpoint", also data added to the system at this stage. On the second stage task of multimedia presentation for conceptual and figurative structures, described in scientific documents, solved. Gaining new knowledge problem solved on the third stage.
Measures to modernize the sintering department of the sinter plant of PJSC “KAMET-STEEL”
Authors: Vodennikova O.S. , Vodennikov S.A. , Bondarenko Ya.V.
Published: May 2023

When producing sinter in the conditions of Ukrainian metallurgical enterprises, it is expedient to use domestic raw materials and try to increase the productivity of sintering shops to global indexes in the range of 5 to 7 million tons/year of sinter. At the same time, the following requirements should be made to the quality of sinter: the highest iron content, the minimum amount of harmful impurities, the stability of the chemical and granulometric compositions, high reducibility and gas permeability, high strength and low content of the fraction less than 5 mm. To increase the competitiveness of sinter production, the following means should be used: construction of sinter plants of a new generation with modern sintering machines; carrying out major repairs and modernization of fixed assets of sinter production; application of energy-saving technologies of sintering et al. The paper proposes measures to modernize the industrial department of sinter plant No. 2 of PJSC “KAMET-STEEL”. To modernize sintering machine No. 7, it is proposed to repair longitudinal and transverse seals of the sintering machine, gas collector, vacuum chambers, dust bags, compensators in the sintering zone, vacuum chambers in the cooling zone, the recovery of thermal insulation on the gas collector, vacuum chambers, and dust bags. The proposed measures make it possible to reduce electricity consumption at the sinter plant, increase the productivity of sintering machine No. 7 to 933.372 tons/year of sinter, reduce the content of fines in the sinter to 8 %, reduce the consumption of solid fuel to 20 %, and increase the service life of the equipment (exhauster rotors and pallet carts with grates).
Computer modeling of the process of siphon casting of a large metal cylindrical ingot
Authors: Kostetskyi Yu.V. , Volchenkov Ye.О. , Stovpchenko G.P. , Tatskyi Ye.V.
Published: May 2023

Electroslag remelting is one of the main ways to obtain high-quality large ingots from special steels and alloys, and in particular for the needs of power engineering. Casting in a mold is the most common way to obtain large-sized consumable electrodes for electroslag remelting. Computer modeling was carried out to determine the rational parameters of the process of casting large cylindrical ingots by the uphill casting. This paper presents the simulation results of the movement of liquid metal flows during the filling of a mold with liquid metal and the process of forming a crust of solid metal at that time under the conditions of the uphill casting of a round steel ingot with a diameter of 1 m with a height-to-diameter ratio of 6.5 and a mass of about 40 tons. Analysis of the results of computer simulation shows that in the bath of liquid metal in the mold there is a non-stationary hydrodynamic picture, which changes as the internal volume of the caster is filled with liquid metal. Solidification of the metal begins already at the initial stage of filling the mold. However, under the influence of liquid metal flows, the formation of a crust of solidified metal occurs unevenly due to the uneven distribution of the heat flow from the liquid-metal bath around the perimeter and height of the mold wall, which creates conditions for the hot surface cracks occurrence. To prevent the formation of surface defects, it is recommended to take measures to stabilize the upward flow of liquid metal. The effect of mold preheating on the intensity of metal solidification during the filling of the mold with liquid metal was also investigated. Preheating reduces the amount of solid phase formed during the filling of the mold with liquid metal. The most significant inhibition of the formation of a solid phase with a decrease in the solidified metal volume fraction of 40 % is observed under the condition of preheating the mold wall to at least 550–600 °C.
On Stable Sampling and Interpolation in Bernstein Spaces
Authors: López Nicolás José Alfonso
Published: May 2023

We define the concepts of stable sampling set, interpolation set, uniqueness set and complete interpolation set for a quasinormed space of functions and apply these concepts to Paley-Wiener spaces and Bernstein spaces. We obtain a sufficient condition on a uniformly discrete set to be an interpolation set based on a lemma of convergence of series in Paley-Wiener spaces. We also obtain a result of transference, Kadec type, of the property of being a stable sampling set, from a set with this property to other uniformly discrete set, which we apply to Bernstein spaces.
Reclaiming presence
Authors: Silva Daniel N. , Dziuba Allison
Published: May 2023

Political actors’ embedding of the here-and-now of enunciation into constructions of gender, sexuality and race is a deictic practice that can be uncoupled from its context and projected into political fields. This article unpacks alternative invocations of the deictic field by Jair Bolsonaro’s new right in Brazil and by Marielle Franco, a queer Black councilwoman who was assassinated in 2018, the same year Bolsonaro was elected president. While Bolsonaro has vilified progressive tropes, such as gender equality, sex positive education and Marielle’s legacy, Marielle and later her mourning movement have mapped her here-and-now onto mottos such as ‘Marielle lives’, which defy chronologic time. Marielle’s central figure has thus been ‘present’ across the political spectrum – for progressives as a figure of immanence, and for white supremacists as a symbol of the Black gendered body whose life is not mournable but whose phantasmatic presence is a continuing threat.
‘We have the best gays, folks’
Authors: Brotherton Chloe
Published: May 2023

In the wake of the 2016 election of Donald Trump, users on the pro-Trump online forum thedonald.win engaged in violently homophobic and Islamophobic discourses. This study uses a critical discourse analytic approach to investigate how users on this forum contradictorily invoke homosexuality to construct Muslims as sexually deviant while also situating them as homophobic and therefore incompatible with the users’ brand of American nationalism. This is an example of homonationalism, using the United States’ supposed tolerance of homosexuality to uphold American exceptionalism and paint Muslims as anti-gay and thus anti-American. While this form of homonationalism was originally formulated in the immediate aftermath of 9/11, the presidency of Donald Trump has altered the way the homonationalist project is discursively constructed on an interactional level.
Of tradwives and TradCaths
Authors: Tebaldi Catherine , Baran Dominika
Published: May 2023

Building on Borba’s theorisation of the anti-genderism register, the articles in this special issue explore anti-genderism as a political tool for the global right in four cases: online ‘tradwives’ or traditional wives defending national and sexual purity (Tebaldi), homonationalism in the Islamophobic forum r/thedonald (Brotherton), the natalist chronopolitics of Bolsonaro in Brazil (Silva and Dziuba) and the invocation of the spectre of gender to place Poland at the centre of the white West (Baran). Together, they highlight new discursive elements in the nationalist far-right use of the anti-genderism register and the construction of morally marked figures through nationalist discourses of tradition, sexuality, temporality and place. Anti-genderism is not just a call for ‘traditional’ gender or marriage, but the evocation of a gendered nation, an idealised past and a strong future populated with warriors and mothers.
Linguistic engagement as public health
Authors: Russell Eric Louis
Published: May 2023

This short response reframes anti-genderist linguistic and discursive praxes as a viral pathogen, analogous to COVID-19. Accordingly, the four research contributions to this volume document and analyse the spread and virulence of anti-genderist forces. This response makes additional allusions to Gal’s framework accounting for enregisterment. Ultimately, this leads to a call for linguists to be more and more deeply active in the disruption of such semiotic ecosystems and their constituent parts, reconceiving of themselves as akin to public health officers, while also reasserting the place of linguistics and linguistic scholarship in the humanities.
City integrated marketing communication – identification and measurement framework
Authors: Daszkiewicz Magdalena , Mazurek Edyta , Pukas Anetta
Published: May 2023

New challenges resulting from dynamic changes observed in the twenty-first century are driving the evolution of approaches to city marketing communication. This article adapts the integrated marketing communication (IMC) concept for cities and develops a measurement framework and a theoretically consistent, valid, and reliable measurement tool for assessing city integrated marketing communication (CIMC). A literature review and previous qualitative studies provided the basis for conceptualising and identifying the specific constructs of CIMC, namely strategic consistency, interactivity, and stakeholder-centred focus. The research developed a theoretically consistent, valid, and reliable measurement tool for assessing CIMC. Empirical validation of the CIMC scale was conducted on data collected from a survey completed by representatives of municipal offices responsible for marketing communication in 279 Polish cities. The value and originality of this article derive from the development of the measurement framework and the new scale for assessing CIMC, which provide the foundation for further research on model solutions in this area. The measurement tool also contains subscales that can be used in research on specific dimensions of city marketing communication. The CIMC scale will assist practitioners in their decision-making processes and facilitate comparisons of cities in a local and international context.
Unequal pay for equal education! A case of gender wage gap from Punjab, Pakistan
Authors: Tirmazee Zunia Saif
Published: May 2023

This study aimed to quantify the returns to tertiary educational attainment and measures the extent to which these returns differ for men and women. The article provides new empirical evidence of the returns to tertiary education literature by introducing a unique instrument, namely the supply of education to deal with endogeneity. The analysis is implemented using a pooled cross-section of five rounds of the Pakistan Social and Living Standards survey with 10,000 observations. The results show that the marginal returns to acquiring one extra year of education beyond matriculation are higher for women than for men. This result could partially explain the reversal of the gender gap in enrolments from secondary and lower to the post-secondary level of education in Punjab. The first stage results highlight the significance of investing in physical infrastructure for the greater accumulation of human capital.
Should Poland join the euro area? The challenge of the boom-bust cycle
Authors: Karnowski Jakub , Rzońca Andrzej
Published: May 2023

The article makes references to the existing cost-benefit analyses on adopting the euro in Poland and other new member states of the EU. In general, they considered a decrease in the cost of capital to be among the crucial benefits of adopting the common currency. As a result, the costs of a credit boombust cycle, to which adoption of the euro may lead, were at best underestimated. The authors discussed the possible solutions to mitigate the risk of boom-bust cycles and concluded that although they are conceptually simple, their effective implementation may be difficult, mostly due to political pressures. To overcome the feasibility problem, the power over undertaking macro prudential measures should be delegated to the central bank. Its past performance in stabilising the economy (at least until recently) suggests that it could make a good use of such a power. Furthermore, adopting the euro would resolve the problem of the ‘difficult cohabitation’ of monetary and macro prudential policy that such a delegation would otherwise create.
Cotidiano e desafios da enfermagem em unidades hospitalares COVID-19: perspectiva dos profissionais
Authors:   Universidade Federal de Santa Maria (UFSM), Flores Coelho Centenaro Alexa Pupiara , de Andrade Andressa , Alves Bonow Clarice , da Costa Marta Cocco , Marion da Silva Rosângela , Rincón Sepúlveda Jesica Johanna
Published: May 2023

Introdução: O trabalho de enfermagem em unidades hospitalares COVID-19 é complexo, desafiador e repleto de elementos cuja compreensão é importante para o campo da Gestão e Saúde no Trabalho. Objetivo: Compreender o cotidiano e os desafios de trabalhadores de enfermagem na linha de frente do enfrentamento à pandemia em unidades hospitalares COVID-19. Materiais e Métodos: Estudo qualitativo desenvolvido com 35 trabalhadores de enfermagem em unidades COVID-19 de sete hospitais do Sul do Brasil, por meio de entrevistas semiestruturadas. O software NVivo auxiliou no tratamento dos dados a partir da análise temática de conteúdo. Resultados: Da análise dos dados emergiram duas categorias analíticas: Desafios do cotidiano de enfermagem nas unidades COVID-19: complexidade e demandas da assistência; e Desafios de ser um trabalhador de enfermagem da linha de frente: desdobramentos no bem-estar profissional e na vida pessoal. Discussão: Pode-se considerar que a complexidade e intensificação do trabalho na linha de frente causou impactos que podem conduzir os trabalhadores de enfermagem ao adoecimento. São importantes ações de promoção à visibilidade profissional junto à sociedade para desmistificar a imagem romantizada sobre a profissão e problematizar a importância da enfermagem no enfrentamento da pandemia e os impactos sofridos por estes trabalhadores. Conclusão: Trabalhadores de enfermagem de unidades COVID-19 vivenciam desafios complexos, com repercussões em sua experiência laboral e em sua vida.
VUCA environment on project success: The effect of project management methods
Authors: Moura Ralf , Carneiro Teresa , Dias Taciana
Published: May 2023

Due to the ever-changing work environment in the age of digital transformation, project managers need to adapt to an environment which is volatile, uncertain, complex, and ambiguous (VUCA). Many organizations adopt management methods based on strict project management planning, assuming that they are the best way to succeed in any situation. However, projects may depend on flexibility to achieve success. This study aims to analyze the impact of adverse project environments on project success and the effect of the management method choice. A PLS-SEM model is tested on a survey of 332 project professionals. Findings showed that choosing a method that best fits the project’s environment can help catch up on project success only when it undergoes frequent changes throughout its life cycle.
A Theoretical Model to Discuss Tax Avoidance Based on Game Theory
Authors: Gomes Antônio , Cunha Jacqueline , Francisco José , Lara Fabiano
Published: May 2023

A consolidated research line in Brazil identified the proxies for determining the tax aggressiveness of companies listed on the B3 stock exchange. However, none of these studies identified the instrument used by Brazilian companies to carry out tax aggressiveness. Thus, our research seeks to fill this gap by demonstrating that fiscal aggressiveness results from the Brazilian tax complexity, that providing prerogatives to avoid or delay tax payments. Besides, this study is the first accounting study to demonstrate that special installments reduce the actual value of taxes owed by taxpayers, encouraging them to be tax aggressive. Through the foundations of Game Theory, this research demonstrates the cost-benefit of tax aggressiveness in maximizing the profit of tax avoidance. We examined the best strategic decisions in the tax avoidance game concerning the tax complexity and special installments experienced in Brazil. In this game, the only NASH equilibrium is tax avoidance since it is the only option with a chance of remuneration. Therefore, this research contributes to understanding business behavior concerning the Brazilian tax system and provides subsidies to encourage reform of the current tax complexity.
Ten Years After the 2008 Crisis: Has Risk Aversion Won?
Authors: Torga Eliana , Roma Carolina , Roma Paula , Ferreira Bruno
Published: May 2023

The aim of this paper is to investigate the performance of low-volatility portfolio strategies representing risk aversion after the 2008 global financial crisis. Five investment portfolios were built by taking into consideration the weight distribution criteria defined by the inverse of the standard deviation of assets, the natural logarithm and exponential of these values, as well as the minimum variance and tangent portfolios, based on the SP 500 futures index, dollar futures index, US government long-term bond (10-year Treasury Bond) and gold futures. The design of the strategies used both twelve- and thirty-month rolling windows for the standard deviation and conditional volatility estimates. Mean return of portfolio, risk through standard deviation, Sharpe index, and risk-adjusted return were calculated for evaluation purposes. Results have evidenced that, together, risk-based portfolios using 12-month rolling window or conditional volatility were superior to the tangent portfolio, as well as that the minimum variance portfolio was competitive to other alternatives. The main contribution of the current study lies in the fact that risk aversion was relevant to portfolios’ performance in the post-crisis period.
Espiritualidade como categoria resultante de interações (conflituosas) entre comunidades terapêuticas e Estado
Authors: Cortez Ana Claudia , Barroso Priscila Farfan
Published: May 2023

Resumo: O objetivo do artigo é discutir como o Estado brasileiro tem buscado regulamentar práticas religiosas em comunidades terapêuticas (CTs) e como elas reagem a esse movimento. Para isso, analisamos as normativas nacionais que regulamentam as CTs no Brasil e realizamos estudo de caso sobre o estado de São Paulo. A metodologia baseia-se na triangulação de técnicas: revisão bibliográfica, análise documental e entrevistas. Nosso principal argumento é que a categoria espiritualidade é coconstruída a partir de interações e conflitos, se tratando de um encaixe institucional que, ao mesmo tempo em que permite a manutenção da religião como um dos tripés do tratamento proposto pelas CTs, também assegura a elas um caráter de pluralidade religiosa, abrindo espaço para o financiamento estatal.
Nuevas cartografías de la incidencia regional evangélica: política local-multilateral desde y dentro del Sistema Interamericano de Derechos Humanos. Ejemplos del caso chileno
Authors: Panotto Nicolás
Published: May 2023

Resumen: El presente trabajo desarrollará algunas indagaciones en torno a la participación de organizaciones evangélicas dentro de redes de sociedad civil en el marco del Sistema Interamericano de Derechos Humanos (SIDH), a través de lo que denominamos como Redes Políticas Evangélicas (RPE), identificando algunas transformaciones en los modos de incidencia de estos colectivos, desde instancias multilaterales hacia anclajes locales, y viceversa. El objetivo es dar cuenta de las nuevas dinámicas transnacionales y multilaterales que operan en espacios ligados al campo evangélico latinoamericano, examinando la participación de Coaliciones Evangélicas en el Diálogo de Sociedad Civil de la Organización de Estados Americanos (OEA) y su impacto en el impulso de narrativas político-morales dentro del llamado neoconservadurismo religioso, para luego analizar cómo estas instancias son instrumentalizadas y operativizadas por agentes locales chilenos.
Dissolving the Self: the cognitive turn of the extended mind theory
Authors: Peruzzo Júnior Léo , Stroparo Amanda Luiza
Published: May 2023

Abstract: In this article, we intend to show how the theory of the extended mind, particularly Andy Clark’s arguments, can explain mental processes not as restrictive phenomena to the brain and endorse their connection to the body and the environment. Therefore, initially, we reconstruct the main materialist perspectives that have enclosed the self to the cranium; then, we indicate how the extended character of the mind escapes its natural limits and blends “shamelessly” into the world. We argue that external artifacts play an important role in guiding our actions, so that changes in the environment can cause changes in the behavior of the cognitive agent, what constitutes a constitutive dependence. In this way, the extended mind thesis challenges both traditional functionalism and externalism as it considers cognitive processes, on the one hand, to be relevant interactions of the individual with the environment and, on the other, intention-driven behaviors. Through the integration of biological bodies with artifacts or tools, we support a reading that dissolves the classic “explanatory gap” of cognitive sciences.
Impulso criador e drama vital em Bergson
Authors: Paiva Rita
Published: May 2023

Resumo: Ao voltar-se para a teoria de H. Bergson acerca do processo evolutivo, este texto toma como objeto de reflexão o caráter antinômico das tendências fundamentais do movimento vital: tempo puro e materialidade. Partindo da importância da imagem, nessa filosofia, debruça-se sobre a ontologia bergsoniana, problematizando tanto a noção de elã vital quanto o modo pelo qual a matéria advém e o tempo real nela se inscreve. Ao destacar a ambiguidade do papel desempenhado pela materialidade, no tensionamento das forças vitais, a discussão explicita que o impulso originário instaura, ele próprio, seu antípoda. Revela-se, assim, o caráter dramático que impregna o movimento intrínseco à história da vida, no qual esforço e luta são correlatos dos limites do impulso que a move e quesitos incontornáveis para o ato criador que a define.
Low concentrations of grape seed extract maintain osteoblast morphology, cell adhesion, and mineralization
Authors: Coelho Maria Carolina , Vetucci Viviann Ruocco , Fernandes Roger Rodrigo , Sanchez Paula Katherine Vargas , Siessere Selma , Bombonato-Prado Karina Fittipaldi
Published: May 2023

Abstract The increase in life expectancy has led to a higher incidence of osteoporosis, characterized by an imbalance in bone remodeling. Several drugs are used for its treatment, but most promote undesirable side effects. The present investigation evaluated the effects of two low concentrations of grape seed extract (GSE) rich in proanthocyanidins on MC3T3-E1 osteoblastic cells. The cells were cultured in an osteogenic medium and divided into control (C), 0.1 µg/mL GSE (GSE0.1), and 1.0 µg/mL GSE (GSE1.0) groups to evaluate cell morphology, adhesion, and proliferation, in situ alkaline phosphatase (ALP) detection, mineralization and immunolocalization of osteopontin (OPN). The data obtained were analyzed by statistical tests for a significance of 5%. Cell morphology was maintained with both GSE concentrations, whereas cell adhesion significantly increased within three days in all groups. Cell proliferation increased significantly at seven days of culture, followed by a significant decrease in all experimental periods, with no statistical difference among them. In situ detection of ALP and mineralization increased with time, but within each period, no statistical differences among groups were observed. The expression of osteopontin was distributed regularly with more intensity after 24 hours in the GSE0.1 group. After three days, OPN expression was more intense in the control group, followed by GSE0.1 and GSE1.0 groups. Data obtained suggest that low concentrations of GSE do not affect the morphology and may stimulate the functional activity of osteoblastic cells.
Effect of experimental bleaching gels with polymers Natrosol and Aristoflex on the enamel surface properties
Authors: Gonçalves Iana Maria Costa , Sobral-Souza Danielle Ferreira , Roveda Jr Antonio Carlos , Aguiar Flávio Henrique Baggio , Lima Débora Alves Nunes Leite
Published: May 2023

Abstract Natrosol and Aristoflex® AVC polymers are widely applied in the cosmetic industry and have recently been applied as a thickener option in the composition of dental bleaching gels, with the purpose to reduce the adverse effects on enamel mineral components. The aim of this study was to evaluate the color variation (ΔE* ab, ΔE00, ∆WID), surface roughness (Ra), and mineral content quantification (Raman Spectroscopy) of dental enamel after bleaching treatment with experimental gel-based on 10% carbamide peroxide (CP), containing Carbopol, Natrosol, and Aristoflex® AVC. Sixty bovine teeth were randomly divided into 6 groups (n=10): Negative Control (NC) - no treatment; Positive Control (PC) - Whiteness Perfect 10% - FGM; CP with Carbopol (CPc); CP with Natrosol (CPn); CP with Aristoflex® AVC (CPa); NCP - no thickener. Data were analyzed, and generalized linear models (∆WID -T0 x T1) were used for repeated measurements in time for Ra and with a study factor for ΔE* ab and ΔE00. For the evaluation of the mineral content, data were submitted to one-way ANOVA and Tukey tests. For enamel topographic surface analysis the Scanning Electron Microscope (SEM) was performed. A significance level of 5% was considered. ΔE* ab and ΔE00 were significantly higher for CPc, CPn, CPa, and NCP groups. (∆WID) showed a significantly lower mean than the other groups for NC in T1. After bleaching (4-hour daily application for 14 days), Ra was higher in the CPc, CPn, and PC groups. For CPa, Ra was not altered. No significant difference was found in the quantification of mineral content. CPa preserved the surface smoothness more effectively. Aristoflex® AVC is a viable option for application as a thickener in dental bleaching gels, presenting satisfactory performance, and maintaining the whitening efficacy of the gel, with the advantage of preserving the surface roughness of tooth enamel without significant loss of mineral content.
Tooth Bleaching: A bibliometric analysis of the top 100 most-cited papers
Authors: Rocha Aurélio de Oliveira , Anjos Lucas Menezes dos , Vitali Filipe Colombo , Santos Pablo Silveira , Bolan Michele , Santana Carla Miranda , Cardoso Mariane
Published: May 2023

Abstract This study analyzes the characteristics of the top 100 most-cited papers related to tooth bleaching. A literature search was performed on the Web of Science up to March 2022. The number of citations was cross-matched with the citation count on Scopus and Google Scholar. The following data were collected: number and density of citations; authorship; year and journal of publication; study design and thematic; keywords; institution and country of origin. Spearman’s correlation and Poisson regression were used to determine associations between the number of citations and study characteristics. The VOSviewer software was used to generate collaborative network maps for the authors and keywords. The number of citations ranged from 66 to 450. Papers were published between 1981 and 2020. The most frequent study design and topic were laboratory-based studies and ‘interaction of the bleaching agent with dental tissues’, respectively. Cochran M, Loguercio AD, Matis B, Reis A, and Suliman M were the authors with the highest number of papers. The countries with the most papers were the United States of America (USA) (28%) and Brazil (20%). Indiana University and State University of Ponta Grossa were the institutions with the most papers (6% each). There was a very strong correlation among the number of citations of the three databases. The 100 most-cited papers related to tooth bleaching were mainly published by the USA and Brazil, with laboratory-based studies addressing topics related to the effects of bleaching agents on tooth structure being the most prevalent.
Molecular identification of pathogenic Escherichia coli virulence genes and histopathological analysis in chickens condemned for airsacculitis
Authors: Dufossé Mylla Christy da Silva , Lima Joelson Sousa , Sampaio Ana Paula Presley Oliveira , Rosa Adrianne Maria Brito Pinheiro da , Silva Josyane Brasil da , Moraes Carina Martins de , Roos Talita Bandeira
Published: May 2023

ABSTRACT: The present study identified virulence genes and pathological changes caused by Escherichia coli in chicken carcasses condemned for airsacculitis and assessed if the histopathological examination and polymerase chain reaction (PCR) were effective for studies like this. Trachea, liver, and lung were collected from 30 chickens with suspected airsacculitis that has been condemned in the inspection line. The samples were analyzed by PCR to simultaneously identify two virulence genes (iss and tsh genes) and for histopathological testing. PCR efficiently genotypically characterize the E. coli isolates, where the virulence genes iss and tsh were found in three birds simultaneously. The histopathological examination detected a predominance of heterophils and mononuclear cells in the trachea (100%), lung (90%), and liver (13.3%). The liver was the organ where practically no alteration was diagnosed. The results of multiplex PCR for the tsh and iss virulence genes indicate the great potential of the approach in the characterization of E. coli isolates. Unspecific identification did not occur, thus making it necessary to use technologies for the identification and prevention of this agent in aviaries and poultry abattoirs.
Jânio Quadros, a questão cubana e a Guerra Fria Latino-Americana, 1961: Testando os limites da Política Externa Independente
Authors: DOMÍNGUEZ AVILA Carlos Federico
Published: May 2023

Resumo O artigo examina a documentação diplomática brasileira vinculada à política do governo do presidente Jânio da Silva Quadros em relação à questão cubana, em 1961. As fontes em apreço foram consultadas no Arquivo do Ministério das Relações Exteriores, sediado em Brasília. Essa comunicação diplomática oferece pouco conhecidas percepções e interpretações sobre o devir da política externa, bem como no tocante às relações entre brasileiros, estadunidenses, cubanos e sovié-ticos. Sob a perspectiva da denominada Política Externa Independente, a principal conclusão do artigo sugere que o governo de Jânio Quadros formulou e implementou uma política externa de princípios em relação à questão cubana. Nessa linha, e em um contexto de marcada competição Leste-Oeste, houve um importante esforço para tentar manter e resolver dentro do sistema interamericano as divergências entre os governos de Washington e Havana, principalmente. Em retrospectiva, infere-se das fontes consultadas que tal diligência política e diplomática foi reconhecida e valorizada pela maioria dos atores com vínculos e interesses no assunto em questão - inclusive em termos domésticos. A pesquisa é realizada sob a perspectiva teórico-metodológica da história das relações internacionais e da análise de política externa.
Avaliação do comportamento cisalhante de misturas solo-emulsão com teores de emulsão variando de 16% a 28% em massa
Authors: Rodrigues Paulo Mateus Barros , Dantas Neto Silvrano Adonias , Babadopulos Lucas Feitos de Albuquerque Lima
Published: May 2023

RESUMO Neste artigo avaliou-se o efeito nos parâmetros de resistência de um solo SM estabilizado com teores de emulsão asfáltica variando entre 16% e 28% em massa. A metodologia consistiu na coleta e caracterização do solo, mistura dos materiais e exposição ao ar por 24 horas, compactação no teor ótimo pela energia Marshall (22%), e em teores acima (28%) e abaixo (16%) do ótimo, e realização de ensaios de compressão triaxial CIU em condições saturadas. O solo apresentou comportamento típico ao de um material elastoplástico com endurecimento, enquanto que as misturas apresentaram comportamento semelhante ao de um material elástico perfeitamente plástico. À medida em que o teor de emulsão foi aumentado, menores foram os ângulos de atrito e, para as misturas com 16% e 22%, maiores foram os interceptos coesivos. A mistura 28% de emulsão teve uma redução em sua coesão, devido ao excesso de ligante, o que prejudicou o contato grão a grão. Constatou-se que após determinado nível de deformação axial as misturas obtiveram um leve ganho de resistência, justificado pelo deslocamento da película de asfalto.