bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Aspects of Persistent Homology Analysis on Phase Transition: Examples in an Effective QCD Model with Heavy Quarks
Authors: Antoku Hayato , Kashiwa Kouji
Published: February 2023

Recently, persistent homology analysis has been used to investigate phase structure. In this study, we apply persistent homology analysis to the QCD effective model with heavy quarks at finite imaginary chemical potential; i.e., the Potts model with the suitably tuned external field. Since we try to obtain a deeper understanding of the relationship between persistent homology and phase transition in QCD, we consider the imaginary chemical potential because the clear phase transition, which is closely related to the confinement-deconfinement transition, exists. In the actual analysis, we employ the point-cloud approach to consider persistent homology. In addition, we investigate the fluctuation of persistent diagrams to obtain additional information on the relationship between the spatial topology and the phase transition.
Validation of a SARS-CoV-2 Surrogate Virus Neutralization Test in Recovered and Vaccinated Healthcare Workers
Authors: Mouna Lina , Razazian Mehdi , Duquesne Sandra , Roque-Afonso Anne-Marie , Vauloup-Fellous Christelle
Published: February 2023

Vaccination against COVID-19 is the main public health approach to fight against the pandemic. The Spike (S) glycoprotein of SARS-CoV-2 is the principal target of the neutralizing humoral response. We evaluated the analytical and clinical performances of a surrogate virus neutralization test (sVNT) compared to conventional neutralization tests (cVNTs) and anti-S eCLIA assays in recovered and/or vaccinated healthcare workers. Our results indicate that sVNTs displayed high specificity and no cross-reactivity. Both eCLIA and sVNT immunoassays were good at identifying cVNT serum dilutions ≥1:16. The optimal thresholds when identifying cVNT titers ≥1:16, were 74.5 U/mL and 49.4 IU/mL for anti-S eCLIA and sVNT, respectively. Our data show that neutralizing antibody titers (Nab) differ from one individual to another and may diminish over time. Specific assays such as sVNTs could offer a reliable complementary tool to routine anti-S serological assays.
Efficacy of Two Vaccination Strategies against Infectious Bronchitis in Laying Hens
Authors: Ali Ahmed , Hassan Mohamed S. H. , Najimudeen Shahnas M. , Farooq Muhammad , Shany Salama , El-Safty Mounir Mohamed , Shalaby Adel A. , Abdul-Careem Mohamed Faizal
Published: February 2023

Vaccination remains the leading control method against infectious bronchitis (IB) in poultry despite the frequently observed IB outbreaks in vaccinated flocks. Here, two vaccination regimes were evaluated against challenge with the Massachusetts (Mass) infectious bronchitis virus (IBV) strain that was linked to egg production defects in Western Canada. One vaccination strategy included live attenuated IB vaccines only, and the other used both inactivated and live attenuated IB vaccines. The two immunization programs involved priming with a monovalent live attenuated IB vaccine (Mass serotype) at day-old, followed by intervals of bivalent live attenuated IB vaccines containing the Mass and Connecticut (Conn) serotypes given to the pullets at 2-, 5-, 9-, and 14-week-old. Inactivated IB vaccine (Mass serotype) was administrated to only one group of the vaccinated birds at 14-week-old. At the peak of lay, the hens were challenged with the Mass IBV isolate (15AB-01) via the oculo-nasal route. The efficacy of the vaccines was assessed following the challenge by observing clinical signs, egg production, egg quality parameters, seroconversion, and systemic T-cell subsets (CD4+ and CD8+ cells). Moreover, the viral genome loads in the oropharyngeal (OP) and cloacal (CL) swabs were quantified at predetermined time points. At 14 days post-infection (dpi), all the hens were euthanized, and different tissues were collected for genome load quantification and histopathological examination. Post-challenge, both vaccination regimes showed protection against clinical signs and exhibited significantly higher albumen parameters, higher anti-IBV serum antibodies, and significantly lower levels of IBV genome loads in OP swabs (at 3 and 7 dpi) and trachea and cecal tonsils compared to the mock-vaccinated challenged group. However, only the birds that received live attenuated plus inactivated IB vaccines had significantly lower IBV genome loads in CL swabs at 7 dpi, as well as decreased histopathological lesion scores and IBV genome loads in magnum compared to the mock-vaccinated challenged group, suggesting a slightly better performance for using live attenuated and inactivated IB vaccines in combination. Overall, the present findings show no significant difference in protection between the two vaccination regimes against the Mass IBV challenge in laying hens.
Development of Methamphetamine Conjugated Vaccine through Hapten Design: In Vitro and In Vivo Characterization
Authors: Hossain Md , Davidson Majid , Feehan Jack , Deraos George , Nurgali Kulmira , Matsoukas John , Apostolopoulos Vasso
Published: February 2023

Background: Methamphetamine (METH) substance-use disorder is an ever-growing global health issue with no effective treatment. Anti-METH vaccines are under investigation as an alternative to existing psychological interventions. This platform has made significant progress over past decades mainly in preclinical stages, and efforts to develop an anti-METH vaccine with a high antibody response are of utmost importance. Methodology: A novel conjugated anti-METH vaccine was developed using METH HCl as the starting material for the design of hapten, a peptide linker consisting of five lysines and five glycines, and finally immunogenic carrier mannan, which is novel to this platform. All the chemical reaction steps were confirmed by several analytical techniques, and the immunogenicity of the developed vaccine was investigated in a mouse model. Results: Thin-layer chromatography and gas chromatography confirmed the reaction between METH and peptide linker. UV, NMR and color tests were used to confirm the presence of the aldehyde groups in oxidized mannan (OM). The final conjugated vaccine was confirmed by UV and LC-MS. The stability of mannan, the METH hapten, and the final vaccine was evaluated by UV and LC-MS and demonstrated satisfactory stability over 3 months in various storage conditions. Animal studies supported the immunogenicity of the novel vaccine. Conclusions: We successfully developed and characterized a novel METH vaccine in vitro and in vivo. The present study findings are encouraging and will form the basis of further exploration to assess its effectiveness to prevent METH addiction in preclinical models.
Development and Evaluation of an Index to Measure the Ability to Get Vaccinated for COVID-19
Authors: Evans William , Bingenheimer Jeffrey , Long Michael , Ndiaye Khadi , Donati Dante , Rao Nandan , Akaba Selinam , Hoglin Bailey
Published: February 2023

The COVID-19 pandemic has been an historic challenge to public health, and to behavior change programs. There have been challenges in promoting vaccination in LMICs, including Nigeria. One important hypothesis deserving consideration is the ability to obtain vaccination as a potential barrier to vaccination uptake. The MOA (motivation, opportunity, and ability) framework, as illustrated by multiple theories such as COM-B, EAST, and the Fogg model, is a primary theoretical basis for the evaluation of this ability as a factor in vaccination uptake. There is little research on measuring the ability to get vaccinated in LMICs, including on the role of all of the MOA framework. The aim of this study was to develop and evaluate an ability factors index measured through social media-based data collected in Nigeria in late 2021 and early 2022. We present findings from an online survey of 8574 Nigerians and highlight new social media-based data collection techniques in this research. This study found that a new ability factors index comprising 12 items was associated with vaccine uptake independent of measures capturing other components of the MOA framework. This index may serve as a valuable research instrument for future studies. We conclude that a person’s perceived ability to get vaccinated, measured by a newly validated index, is related to vaccination uptake and hesitancy, and that more research should be conducted in this area.
COVID-19 Vaccination Attitude and Behavior among Nurses at a West Texas Regional Hospital
Authors: Peterson Christopher J. , Abohelwa Mostafa , Rimu Afrina , Payne Drew , Yang Shengping , Williams Tammy , Rowin Erin Nash , Nugent Kenneth
Published: February 2023

Vaccinations against COVID-19 infection have become a contentious issue in the United States. Multiple segments of society, including healthcare workers, have expressed concerns regarding the need for vaccination and the safety of current vaccines. Many hospital-based nurses have helped care for patients with severe COVID-19 infections. An anonymous online survey was sent to the nursing staff at University Medical Center in Lubbock, TX, USA, through a hospital-based email system to determine vaccination status and attitudes towards the COVID-19 vaccine and other routine vaccines. Multivariable regression analysis was used to determine factors associated with vaccination. A total of 251 nurses responded to this survey; 211 nurses (83.7%) had received the vaccine. Almost all nurses (242, 96%) had received all childhood vaccinations, and 231 (91.7%) had received an influenza vaccination in the prior year. A minority of nurses (75, 29.8%) supported mandatory vaccination for healthcare workers. The reasons for declining vaccination included the possibility that diet and alternative medications provided better protection against COVID-19. This survey demonstrates that over 80% of nurses working in a hospital managing very sick patients with COVID-19 infection had been vaccinated. However, nurses who did not take the annual influenza vaccine and did not consider other protective measures useful (such as mask-wearing) were significantly less likely to vaccinate. Nurses can provide an important resource for conversations with the public and patients about vaccine initiatives.
A Pentavalent Shigella flexneri LPS-Based Vaccine Candidate Is Safe and Immunogenic in Animal Models
Authors: Ledov Vladimir A. , Golovina Marina E. , Alkhazova Biana I. , Lvov Vyacheslav L. , Kovalchuk Alexander L. , Aparin Petr G.
Published: February 2023

A multivalent vaccine is much needed to achieve protection against predominant Shigella serotypes. Recently, we demonstrated the clinical applicability and immunogenic potential of tri-acylated S. flexneri 2a lipopolysaccharide (Ac3-S-LPS). Using a similar approach, we designed a pentavalent LPS candidate vaccine against S. flexneri 1b, 2a, 3a, 6, and Y (PLVF). In this study, we performed molecular and antigenic characterization of the vaccine candidate and its preclinical evaluation. There were no signs of acute toxicity after subcutaneous administration of PLVF in rabbits at a proposed human dose of 125 μg. No pyrogenic reactions and adverse effects associated with chronic toxicity after repeated administration of PLVF were revealed either. The immunization of mice with PLVF led to ≥16-fold increase in S. flexneri 1b-, 2a-, 3a-, 6-, and Y-specific antibodies. In a serum bactericidal antibody (SBA) assay, we registered 54%, 66%, 35%, 60%, and 60% killing of S. flexneri 1b, 2a, 3a, 6, and Y, respectively. In the guinea pig keratoconjunctivitis model, the efficacy was 50% to 75% against challenge with all five S. flexneri serotypes. These studies demonstrate that PLVF is safe, immunogenic over a wide range of doses, and provides protection against challenge with homologous S. flexneri strains, thus confirming the validity of pentavalent design of the combined vaccine.
Evaluation of ROTARIX® Booster Dose Vaccination at 9 Months for Safety and Enhanced Anti-Rotavirus Immunity in Zambian Children: A Randomised Controlled Trial
Authors: Laban Natasha Makabilo , Bosomprah Samuel , Simuyandi Michelo , Chibuye Mwelwa , Chauwa Adriace , Chirwa-Chobe Masuzyo , Sukwa Nsofwa , Chipeta Chikumbutso , Velu Rachel , Njekwa Katanekwa , Mubanga Cynthia , Mwape Innocent , Goodier Martin Rhys , Chilengi Roma
Published: February 2023

Oral rotavirus vaccines show diminished immunogenicity in low-resource settings where rotavirus burden is highest. This study assessed the safety and immune boosting effect of a third dose of oral ROTARIX® (GlaxoSmithKline) vaccine administered at 9 months of age. A total of 214 infants aged 6 to 12 weeks were randomised to receive two doses of ROTARIX® as per standard schedule with other routine vaccinations or an additional third dose of ROTARIX® administered at 9 months old concomitantly with measles/rubella vaccination. Plasma collected pre-vaccination, 1 month after first- and second-dose vaccination, at 9 months old before receipt of third ROTARIX® dose and/or measles/rubella vaccination, and at 12 months old were assayed for rotavirus-specific IgA (RV-IgA). Geometric mean RV-IgA at 12 months of age and the incidence of clinical adverse events 1 month following administration of the third dose of ROTARIX® among infants in the intervention arm were compared between infants in the two arms. We found no significant difference in RV-IgA titres at 12 months between the two arms. Our findings showed that rotavirus vaccines are immunogenic in Zambian infants but with modest vaccine seroconversion rates in low-income settings. Importantly, however, a third dose of oral ROTARIX® vaccine was shown to be safe when administered concomitantly with measles/rubella vaccine at 9 months of age in Zambia. This speaks to opportunities for enhancing rotavirus vaccine immunity within feasible schedules in the national immunization program.
Tixagevimab and Cilgavimab (Evusheld™) Prophylaxis Prevents Breakthrough COVID-19 Infections in Immunosuppressed Population: 6-Month Prospective Study
Authors: Jakimovski Dejan , Eckert Svetlana P. , Mirmosayyeb Omid , Thapa Sangharsha , Pennington Penny , Hojnacki David , Weinstock-Guttman Bianca
Published: February 2023

Background: Persons with neuroinflammatory diseases (pwNID) treated with potent immunosuppressives are at risk of severe COVID-19 outcomes and reduced vaccine seroconversion. We aimed at determining the real-world efficacy of tixagevimab and cilgavimab (Evusheld™) in immunosuppressed pwNID in preventing breakthrough COVID-19 infections. Methods: 31 immunosuppressed pwNID were followed for 6 months after administration of tixagevimab and cilgavimab as a prophylactic COVID-19 medication (January 2022–July 2022). Only pwNID treated with anti-CD20 monoclonal antibodies and sphingosine-1-phosphate modulators were considered eligible for the study. A control group of 126 immunosuppressed pwNID (38 seropositive and 88 seronegative after SARS-CoV-2 vaccination) were included. Breakthrough COVID-19 infections rate and their severity was determined over the follow-up. Results: The pwNID treated with tixagevimab and cilgavimab had more comorbidities when compared with the total and seronegative pwNID control group (54.8% vs. 30.2% vs. 27.3%, p = 0.02 and p = 0.005, respectively). After a 6-month follow-up, significantly lower numbers of pwNID treated with tixagevimab and cilgavimab had breakthrough COVID-19 when compared with the control pwNID group (6.5% vs. 34.1%, p = 0.002) and seronegative control pwNID group (6.5% vs. 38.6%, p < 0.001). All COVID-19 infections in Evusheld-treated pwNID were mild, whereas 9/43 COVID-19 infections in the control group were moderate/severe. No side effects to tixagevimab and cilgavimab were recorded. Conclusion: In pwNID treated with immunosuppressive therapies, tixagevimab and cilgavimab (Evusheld™) significantly reduced the numbers and severity of breakthrough COVID-19 infections during the Omicron (BA.2–BA.5 variants) wave.
Epidemiological Associations between Rabies Vaccination and Dog Owner Characteristics
Authors: Amemiya Yuri , Inoue Satoshi , Maeda Ken , Nishiura Hiroshi
Published: February 2023

Background: The annual rabies vaccination coverage in dogs among 47 prefectures in Japan has been reported to range from 42.3% to 92.4%, and the overall coverage has been steadily declining. Given the presence of unregistered dogs and the small number of stray dogs, the true vaccination coverage is likely to be even lower. Methods: We conducted a cross-sectional survey of dog owners to identify the owner characteristics associated with dog rabies vaccination. People in Japan who currently own dogs were recruited and answered a questionnaire consisting of four sections: (i) demographic characteristics, (ii) education history associated with medicine, (iii) factors related to veterinary services, and (iv) dog characteristics. Results: A total of 534 dog owners covering 629 dogs were surveyed. Vaccination within the prior 12 months was the major outcome (56.1%). The associated variables were (a) owner education level, (b) knowledge about mandatory vaccination, (c) having a family veterinary clinic, (d) frequency of visiting a veterinary clinic, and (e) having ever been advised to vaccinate their dog. Conclusions: Although causality cannot be implied, our findings indicate improving owners’ knowledge about mandatory vaccination, facilitating attachment to a veterinary clinic, and veterinarians providing vaccination advice might increase the uptake of dog rabies vaccination. The finding in Japan did not deviate from Asian and African countries with rabies, and the sample estimate of annual vaccination coverage was lower than the reported estimate among registered dogs.
Prevalence and Predictors of Seasonal Influenza Vaccine Uptake in Saudi Arabia Post COVID-19: A Web-Based Online Cross-Sectional Study
Authors: Alshahrani Saeed Mastour , Zahrani Yousef
Published: February 2023

In the fall of 2022, the number of influenza-like illnesses (ILIs) and severe acute respiratory infections (SARIs) in Saudi Arabia had significantly increased compared with the corresponding period in previous years. Concerns regarding the population’s seasonal influenza vaccine (SIV) uptake rates have emerged. In particular, the SIV uptake rates may have dropped post the COVID-19 pandemic compared with rates prior to the COVID-19 era. In this study, we aimed to estimate the prevalence and predictors of SIV uptake in Saudi Arabia post the COVID-19 pandemic. We conducted a cross-sectional study utilizing an online survey platform. We mainly collected sociodemographic information and determined whether the respondent was a healthcare professional or had a chronic disease. The overall SIV uptake prevalence was 31.8%. A lower SIV uptake was observed among those aged 55 years or older, females, residents of the central region, non-health practitioners, and those without chronic diseases. Several factors were associated with SIV uptake. Those aged 35–44 were over three-fold more likely to receive an SIV than those aged 55 years or older (OR: 3.66; 95% CI: 1.33–10.05). In addition, males had 73% higher odds of SIV uptake than females (OR: 1.73; 95% CI: 1.18–2.55). Health practitioners were more likely to receive an SIV than non-health practitioners (OR: 2.11; 95% CI: 1.45–3.06). Similarly, those with chronic diseases had 86% higher odds of SIV uptake than those without chronic diseases (OR: 1.86; 95% CI: 1.18–2.95). These findings can provide insights into the low prevalence and predictors of SIV uptake in Saudi Arabia. Future studies should be conducted to further explore the potential factors associated with such a low prevalence of SIV uptake post COVID-19 in Saudi Arabia.
Long-Term Immunological Memory of SARS-CoV-2 Is Present in Patients with Primary Antibody Deficiencies for up to a Year after Vaccination
Authors: Lucane Zane , Slisere Baiba , Ozola Lota , Rots Dmitrijs , Papirte Sindija , Vilne Baiba , Gailite Linda , Kurjane Natalja
Published: February 2023

Some studies have found increased coronavirus disease-19 (COVID-19)-related morbidity and mortality in patients with primary antibody deficiencies. Immunization against COVID-19 may, therefore, be particularly important in these patients. However, the durability of the immune response remains unclear in such patients. In this study, we evaluated the cellular and humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in a cross-sectional study of 32 patients with primary antibody deficiency (n = 17 with common variable immunodeficiency (CVID) and n = 15 with selective IgA deficiency) and 15 healthy controls. Serological and cellular responses were determined using enzyme-linked immunosorbent assay and interferon-gamma release assays. The subsets of B and T lymphocytes were measured using flow cytometry. Of the 32 patients, 28 had completed the vaccination regimen with a median time after vaccination of 173 days (IQR = 142): 27 patients showed a positive spike-peptide-specific antibody response, and 26 patients showed a positive spike-peptide-specific T-cell response. The median level of antibody response in CVID patients (5.47 ratio (IQR = 4.08)) was lower compared to healthy controls (9.43 ratio (IQR = 2.13)). No difference in anti-spike T-cell response was found between the groups. The results of this study indicate that markers of the sustained SARS-CoV-2 spike-specific immune response are detectable several months after vaccination in patients with primary antibody deficiencies comparable to controls.
Assignment Approach for Electric Vehicle Charging Using Traffic Data Collected by SUMO
Authors: Farhani Riham , El Hillali Yassin , Rivenq Atika , Boughaleb Yahia , Hajjaji Abdelowahed
Published: February 2023

Consumption habits are changing due to the development of new technologies around renewable energy, environmental awareness, and new incentive policies. Smart grids are seen as an effective way to accommodate more renewable energy, achieve better control of demand, and improve the operating conditions of the electrical system. However, electric vehicles, which are an environmentally friendly alternative, have very high market penetration and require efficient electrical management at charging stations. Among the factors that have a significant impact on electrical energy consumption are traffic conditions, which can seriously impact the efficiency of electric vehicles. Therefore, the focus is on developing charging infrastructure and reducing vehicle waiting time by optimally allocating electric vehicles to charging stations. To this end, an optimization approach is presented, based on the traffic conditions collected by the SUMO simulator. This approach enables each vehicle to be assigned to the appropriate station while maintaining its battery state of charge at a higher level.
Digital analysis of stomatognathic system morphofunctional condition in patients with distal occlusion before and after treatment with the Twin Block appliance
Authors: Shiryaeva T. V. , Oborotistov N. Yu. , Muraev A. A.
Published: February 2023

Relevance. For many years studies have evaluated the possibilities of modifying the growth of the maxillofacial complex during orthodontic treatment with functional appliances. Despite the large number of studies devoted to orthodontic treatment of distal occlusion in children and adolescents, there is no consensus among orthodontists on the appropriateness, timing and tactics of such treatment.Material and methods. The article presents the results of the treatment of distal occlusion in children and adolescents aged 7-18 years using the Twin Block appliance. The study included clinical, anthropometric, radiographic and functional research methods.Results. The course of treatment eliminated distal occlusion in all groups; in Group 1, the length of the mandibular body was 64.4 ± 2.8 mm before the treatment and 69.6 ± 2.4 mm after the treatment (p = 0.016); in Group 2, the length of the mandibular body was 69.7 ± 6.6 mm before the treatment and 72.5 ± 6.9 mm after the treatment (p = 0.019); in Group 3, the length of the mandibular body was 69.8 ± 5.6 mm before the treatment and 74.0 ± 4.3 mm after the treatment (p = 0.005). The temporomandibular joints did not show pathological changes; most patients (70%) did not demonstrate anterior position of the condyles after the treatment.Conclusion. Orthodontic treatment of patients aged 7-18 years with distal occlusion using the Twin Block appliance is an effective treatment method. The orthodontic treatment with functional appliances is most reasonable during the period of peak growth when significant skeletal changes are possible to obtain.
Xerostomia in patients with diabetes mellitus (pilot study)
Authors: Kuletskaya K. , Tikhomirova E. A. , Slazhneva E. S. , Atrushkevich V. G.
Published: February 2023

Relevance. Saliva performs some essential functions indispensable for oral health. Patients with diabetes mellitus (DM) often complain of xerostomia. Long-term dry oral mucosa in diabetic patients adversely affects the quality of life and causes speech. chewing. swallowing. and taste problems; it leads to multiple caries and inflammatory periodontal diseases.Aim. To evaluate the detection rate and determine the x erostomia nature in patients with DM.Materials and methods. The interview and survey included 251 patients aged 18-82 y.o. with Type 1 DM. latent auto-immune diabetes in adults and Type 2 DM. The patients informed the study of DM duration. current therapy duration. xerostomia presence and nature. The patients’ records provided information about the established diagnosis. age. glycohemoglobin (HbA1c). body mass index (BMI). and prescribed DM therapeutic regimen. The data were statistically analysed using the StatTech v. 2.4.8 software. Results. 134 (53.4%) patients complained of a transient dry mouth associated with blood sugar levels increase; 6 (2.4%) patients noted dry mouth if blood sugar levels decreased; 30 subjects (12.0 %) and 10 subjects (4.0 %) reported constant and stress-associated dry mouth. respectively (р > 0.05). Patients over 80 declared dry mouth associated with blood sugar decrease more often than patients aged 45-64 and 65-80 y.o. (р = 0.002*; р45-64 – over 80 = 0.012; рover 65 – over 80 < 0.001); 21.1% of patients aged 65-80 noted permanently dry mouth (р = 0.028). Patients with persisting xerostomia (permanent dry mouth and stress-associated dry mouth) had statistically significant. higher BMI of 33 (31-37) kg/m2 (р = 0.019) and 36 (34-41) kg/m2 (р = 0.002). respectively. The higher glycohemoglobin level increase was more statistically significant in patients with DM. who reported dry mouth associated with glucose increase. The evaluation of xerostomia nature vs to diagnosis. sex. DM duration. drug therapy scheme. and smoking did not reveal any statistically significant differences.Conclusion. Xerostomia presents an additional problem for patients with DM. Patient education and the selection of individual products for oral care by dentists may improve oral health parameters in the long run.
FAGGA appliance for treatment of sagittal discrepancies in adults: a clinical case
Authors: Yaakub D. D. , Oksentyuk A. D. , Admakin O. I.
Published: February 2023

Relevance. Skeletal Class III malocclusion is one of the most frequent and challenging problems in orthodontics. This pathology affects both the maxillofacial area function and aesthetics of the patient. Surgery is the most common solution to this problem. The clinical case describes an alternative treatment method using the FAGGA appliance.Clinical case description. The clinical case describes an increase in the upper jaw sagittal dimension in an adult patient who presented for orthodontic correction. The patient was offered treatment with the fixed FAGGA appliance. The treatment resulted in the upper jaw premaxillary zone increase by 3.7 mm, an SNA-angle increase by 2.89 degrees, and positive changes in the facial profile and aesthetics.Conclusion. The described treatment method allowed for the improvement of the aesthetic and functional parameters and the achievement of normal overjet. The patient continues treatment with a bracket system.
UPAYA PENINGKATAN AKTIVITAS DAN HASIL BELAJAR PAIBP TENTANG QODHO’ DAN QODAR DENGAN MODEL PEMBELAJARAN KOOPERATIF TIPE JIGSAW
Authors: Sunarto Sunarto
Published: February 2023

Abstract Qodo and Qodar is the last pillar of faith or the sixth. Qodo and Qodar concepts are similar, but quietly different, so that the students so confuse and have learning difficulties. The purpose of this research is to analyze the enhancement of the VI B students of Public Elementary School 1 Kunduran learning outcomes of Islamic Education and Character about Qodo and Qodar through Cooperative Learning with Jigsaw type on the Second Semester of 2019/2020 Academic Year. This is a Classroom Action Research (CAR). The action is Cooperative Learning with Jigsaw type or Jigsaw Method. The place of this research is on the VI B Class of Public Elementary School 1 Kunduran. The time of this research is the early period on the Second Semester of 2019/2020 Academic Year. The subjects are 14 students, consists of 9 boys and 5 girls. Techniques of collecting data are nontest and test. Tools of collecting data are observation sheet, camera application and test with written question. Technique of analyzing data is comparative-descriptive. The procedure is Kemmis and McTaggart Model. The result is learning outcomes enhanced from unsatisfactory category to satisfying. Keywords: Learning Outcomes, Islamic Education and Character, Qodo’ and Qodar, Cooperative Learning, Jigsaw
Analisis Kajian Metodik Didaktik Pembelajaran PPKn di Sekolah Dasar
Authors: Widiyono Aan
Published: February 2023

Penelitian ini bertujuan untuk menganalisa metodik didaktik pembelajaran PPKn di sekolah dasar. Selain itu, hasil yang dikaji dalam penelitian ini adalah terkait ruang lingkup PPKn di sekolah dasar. Metode penelitian menggunakan studi literatur. Hasil penelitian ini diperoleh bahwa PPKn berkembang sesuai dengan arah perubahan kurikulum dari tahun 1962 sampai dengan kurikulum merdeka dengan istilah yang berbeda. Selain itu, muatan PPKn tentunya berubah sesuai dengan tujuan kurikulum yang diterapkan oleh pemerintah. Muatan materi PPKn menjadi kendala bagi guru karena masih bersifat abstrak dan proses pembelajaran masih belum mengedepankan student centre. Untuk yang terakhir adalah PPKn dapat diterapkan dalam berbagai model pembelajaran salah satunya adalah group investigation dengan hasil yang lebih optimal.
Análise ambiental integrada da bacia hidrográfica do Rio Miringuava: um estudo de caso dos impactos ambientais locais
Authors: Santos Bruno Dalla Nora
Published: February 2023

O estudo de caso específico envolve a Análise Ambiental Integrada da Bacia Hidrográfica do Rio Miringuava, na cidade de São José dos Pinhais, com a utilização de Sistema de Informações Geográficas (SIG), com base no Zoneamento de Uso e Ocupação do Solo municipal e em informações georreferenciadas disponibilizadas em domínio público. Aplica-se também a metodologia “Multi-Criteria Decision Analysis” – MCDA – (Análise Multicritério de Tomada de Decisão) como forma de elencar, valorar e classificar cada parâmetro específico de acordo com seu peso dentro da totalidade do conjunto. Especificamente, com o auxílio de ferramentas computacionais que possibilitem sínteses de alterações significativas em ecossistemas e hábitats, a Análise Ambiental Integrada da Bacia Hidrográfica do rio Miringuava permitiu-se mensurar os efeitos de um empreendimento de barramento de água para formação de reservatório de abastecimento público, chamado “Barragem Miringuava”, e a Companhia de Saneamento do Estado do Paraná irá administrá-la. Desta maneira, a Análise Ambiental Integrada da Bacia Hidrográfica do Rio Miringuava servirá de modo a complementar aos Estudos Ambientais, integrando-se ás análises previamente existentes de modo a municiar o poder público em decisões que envolvam os Ecossistemas e o Meio Ambiente, bem como estabelecer um prognóstico ambiental relacionado à conservação ambiental da fauna e flora local como – também – do Uso e Ocupação do Solo da área designada para a construção da “Barragem Miringuava” e seu respectivo reservatório.
Seguimiento de trayectorias estudiantiles en Moodle para el programa de la MTIE
Authors: Estrada Raúl Armando Valadez , Dávila Susana Cordero , Berumen José de Jesús Hernández , Villalobos Alejandro Rodolfo García , Larios Martha Susana Hernández
Published: February 2023

La presente investigación pretende conocer las necesidades del programa de la Maestría en Tecnología Informática Educativa de la Universidad Autónoma de Zacatecas en lo que respecta al seguimiento de trayectorias estudiantiles de sus alumnos de la modalidad en línea, así como, los requisitos técnicos para desarrollar e implementar un programa conector (plugin) que permita realizar dicho seguimiento en tiempo real en la plataforma LMS Moodle en la que opera dicho programa.
SECI Model Guides the Generation and Diffusion of Knowledge in the Developing of an Innovative Product at a Small Science and Technology Institute
Authors: Amanda da Costa Marques  , Gláucio Bessa Oliveira  , Meire Jane Lima de Oliveira  , Renelson R. Sampaio
Published: February 2023

This research presents a case study about knowledge management at the Plasma Dental Pen project, in its stages of prototyping, conducted by the Núcleo Avançado de Inovação Tecnológica (NAVI) from Rio Grande do Norte. It applies the SECI theoretical-practical model by Nonaka & Takeuchi (1997) to analyze the dialectic of creating organizational knowledge to generate solutions related to the lack of experience with additive manufacturing in this project. For information acquisition, semi-structured interviews were carried out with the coordinator and a researcher from the organization and then compared with the proposed theory of the seminal authors and recent literature about it. We concluded that adapted applications of the SECI model contribute to the generation and diffusion of knowledge in the institution and its innovation process.
Carbon Footprint of Hydrothermal Liquefaction of Microalgae Biomass Cultivated in Availability and Limitation of Nutrients
Authors: Lorena Rodrigues Cunha  , Diego Lima Medeiros  , Ícaro Thiago Andrade Moreira
Published: February 2023

This work aimed to assess the carbon footprint of microalgae biomass processing in hydrothermal liquefaction (HTL) to produce biopetroleum and co-products. The foreground inventory covered the cultivation in open ponds with availability (C1) and limitation (C2) of nutrients, followed by harvesting and processing in HTL for 1 kg of microalgae biomass in total solids. The ecoinvent™ 3.6 databases and IPCC- 2021 GWP 100 years method were used for background inventory and impact indicator in openLCA® 1.11.0. The carbon footprint of C1 (1.1 kg CO2eq) was more significant than that of C2 (0.7 kg CO2eq). The most considerable carbon footprint contribution per stage was the Production stage (cultivation and harvesting), with 64%-88%, in the evaluated scenarios. In comparison, this per process was the fertilizer (71%) in C1 and the heat (32%) in C2.
Temperature Effect in the Babassu (Orbignya speciosa) Oil: A Physico-Chemical Study
Authors: Rebecca da Silva Andrade  , Marta Andrade Pires  , Miguel Angel Iglesias Duro
Published: February 2023

Babassu (Orbignya speciosa) is a Brazilian palm with extraordinary importance in socioeconomic and ecologic terms. It is found in humid tropical areas, especially in degraded landscapes. There are several uses for babassu coconut and babassu oil. However, their immense potential for large-scale providing other industrial products still needs to be explored due to the necessity for modern scale planning and deep knowledge of vast spectrum thermodynamic properties. This paper gathers a new experimental physico-chemical study of the temperature effect on two critical properties, density and ultrasonic velocity for babassu oil, due to its rising economic significance and a high potential for intensive farming in regions with low economic resources. We consider how accurately different theoretical prediction methods work due to modern processes, design, and algorithm simulations being strongly computer-oriented. The Agrawal-Thodos equation for density and Collision Factor Theory for ultrasonic velocity was selected, mainly attending to ease of use and range of application. We observed a good response at the studied conditions, despite geometrical simplifications into triglyceride molecules and using estimated critical magnitudes by molecular group contribution approach. A broad comparison was made with disposable open literature thermodynamic data, showing an essential dispersion of data, and highlighting the quality of the experimental data presented in this work.
Rainwater Reuse at the Gonçalo Moniz Institute – FIOCRUZ-BA
Authors: Carlos Letácio S.L. da Silva  , Roni Dias Vinhas  , Edna dos Santos Almeida  , Bruna Aparecida Souza Machado
Published: February 2023

This work aims to evaluate the reduction in water consumption at the IGM/FIOCRUZ-BA facilities, evaluating the potential for rainwater harvesting. To this end, the areas of roofs with the potential for reuse of rainwater were surveyed, their capture capacities considering rainfall data, in addition to a survey of the institution’s water consumption. We observed significant results in percentages of reduction in water consumption in the case of rainwater reuse and the potential savings generated when compared with the data effectively spent on the water in the IGM. It can be seen that the capture capacities of the roofs and the pluviometric indices of Salvador can provide potential savings to the Instituto Gonçalo Moniz (IGM).
Statistical Study of Eco-Efficiency in Compact and Average Cars (Chevrolet, Ford, VW, Fiat, Renault) in Brazil Based on the Metro Table in 2019
Authors: André Luis Pires Wenceslau Soares  , Adrian Widmer  , Gabriel Souza Dunkel  , Joseph Samuel Neiva  , Orlando Mota Pires  , Aloisio Santos Nascimento Filho
Published: February 2023

This article aimed to identify the most efficient and ecological car models. Based on the analysis of cars classified as “light vehicles” in 2019 by INMETRO data in Brazil. A program in C helped analyze the frequency distribution of the variables of CO2 emission and mileage per liter, allowing us to evaluate the efficiency of the compact and medium models of the “light” class. At the end of the study, there was an emphasis on the eco-efficiency of the vehicle assemblers Fiat and Renault.
Renegotiations and Disallowances by Health Board for Medical-Hospital Care and High-Cost Procedures from Brazilian Army Health System in 2021
Authors: Wagner Elpídio do Nascimento  , Carlos César Ribeiro Santos  , Letícia de Alencar Pereira Rodrigues  , Jonata Souza dos Santos
Published: February 2023

This article describes the worth of renegotiations and disallowances by the Health Board of the Brazilian Army for high-cost procedures in 2021 from all military regions. Its principal objective is to describe the economy resulting from the values renegotiated and/or disallowanced by the Board. The specific purposes are to describe the renegotiated and/or disallowanced values distinguished from each military region, to mention the primary medical specialties, and list the main reasons for renegotiations or disallowances, suggesting measures to outcome the Brazilian Army’s health audit services. It is a retrospective, descriptive, qualitative, and quantitative study. In the results, the 11th, 7th, and 2nd Regions stand out with the highest total values in the authorizations, renegotiations, and denials of 2021. Cardiointervention and Neurosurgery/Neurointervention were the areas with the most significant prominence in values, followed by Orthopedics, Oncology, Urology, and home care. We suggested measures to improve the performance of the Brazilian Army’s health audits teams, such as training and continuous education; elaboration and regular updating of the Standard Operating Procedures in audit processes; the exclusive dedication of audit team members, avoiding functional deviations; construction and updating of local market value indicators for orthoses, prostheses, and special materials; use and regular updating of the Brazilian Army’s assistance protocols; closer communication between the Board of Health, Military Regions and Military Health Organizations. This article explored the theme; however, further research must deepen and corroborate our study.
Hydrogen Production via SMR with Carbon Capture: A Bibliometric Analysis
Authors: Jade Spínola Ávila  , Julio Augusto Mendes da Silva  , Fernando Luiz Pellegrini Pessoa  , Petrucio Leal Pereira
Published: February 2023

The global energy demand should double by 2030, reaching a peak of 80 to 120 million barrels of oil per day. Therefore, to mitigate climate change and reduce the high demand for oil imports, future energies must be clean (carbon-free), renewable and recyclable. A promising solution to reduce dependence on fossil fuels and meet future demands for sustainable energy is to use H2 as an energy vector. In the literature, some works involve H2 production via SMR and CO2 capture. Therefore, a bibliometric analysis of this topic is developed to assess its level of maturity and map the publications most adhering to this research line. From the results obtained, it was observed that the focus of the research already has a particular maturity, but there are still many gaps to be addressed and developed.
Habilidades Socioemocionales para la Escuela Rural del Perú: Aportes Empíricos basados en enfoques Emic y Etic
Authors: Ríos Céspedes Alex Martín , Cabrerizo Rey de Castro Patricia
Published: February 2023

La creciente atención al desarrollo de las habilidades socioemocionales desde principios de siglo ha llevado al desarrollo de diferentes marcos de referencia que impulsan, a su vez, la evaluación del desarrollo socioemocional en la educación. Uno de los desafíos está relacionado con el uso de marcos de referencia de un contexto específico -generalmente el occidental- como propuestas universales para todo contexto cultural. Este artículo tiene como objetivo brindar una contribución empírica a la discusión sobre el uso colaborativo de los enfoques emic y etic en la evaluación e investigación de las habilidades socioemocionales, a partir del análisis de dos estudios realizados con estudiantes de escuelas rurales que participaron en un programa educativo. En el primer estudio, bajo un enfoque etic, 2485 estudiantes de escuelas secundarias públicas ubicadas en zonas rurales de Piura y Ayacucho respondieron un conjunto de escalas tipo Likert para evaluar una propuesta teórica de diez habilidades socioemocionales. En el segundo estudio, siguiendo un enfoque emic, se entrevistó a 65 estudiantes de escuelas secundarias públicas ubicadas en zonas rurales de Piura y Cusco sobre sus percepciones sobre las habilidades socioemocionales valoradas como importantes para el estudio y el trabajo. Los resultados muestran la existencia de habilidades socioemocionales comunes entre los enfoques emic y etic, así como algunas habilidades que son importantes para las comunidades y no son consideradas en el marco conceptual que orientó el enfoque etic en la investigación.
“Virginity”, Search of Pleasure in Female Body: Psychoanalysis of Sexual Violence in Perpetrators
Authors: Poerwandari Elizabeth Kristi
Published: February 2023

This article focuses on the rationalization of perpetrators of sexual offense against women, in a form of re-analysis of data gathered from one police resort in Greater Jakarta. The article presents the data of 9 (nine) suspects who were reported to the police by their girlfriends or the family of their girlfriends. Sexual offense toward women could not be separated from the lower bargaining position of women, as well as the views of sexuality which cornering women. Marrying the victim to the perpetrator is one practice that is still popular to solve the problem, which makes the situation worse for the victim. This also spread the socialization and practices of mean and irresponsible behavior by perpetrator or potential perpetrator. Double standard views on sexuality lead to the vulnerable situation of women, and make it more difficult to fight for justice on the issue of sexual offense. The double standard is also dominating the mind of the general public and even the public official. Therefore, the Law needs to view sexuality and sexual violence in a comprehensive understanding, with gender justice perspectives which also protect children.
Reinterpretation of Sexual Violence Theology: Case Study of Amina Wadud’s Tafsir
Authors: Sa'dan Masthuriyah
Published: February 2023

Sexual violence in the history of humankind is a common phenomena. Ironically the object of violence is frequently women. Unfortunately, those violence are legitimated with doctrine. Cases of husband beating wife as nusyuz and other violences are legitimated with holytexts. Muhamad’s personality to his wives even being used as legitimation of theology. This made interpretation becomes bias. Amina Wadud’s tafsir indicated that there is a need to re-evaluate and reinterprete those bias tafsir.
(Bill Draft on Eliminating Sexual Violence: Access to Justice, Truth and Victims’ Survival
Authors: Khusnaeny Asma'ul
Published: February 2023

Sexual violence is a crime against humanity, violations of human rights and gender-based violence. Meanwhile since the 1998-2013 National Commission on Violence Against Women has been monitoring and documentating 15 (fifteen) forms of sexual violences. National Commission on Violence Against Women was classifying all forms of sexual violence from 15 forms into 6 sexual violences based on common elements in criminal offense. So far the handling cases of sexual violence faced barrier to prevention, protection, recovery of victims, rehabilitation of offenders, and the criminal justice procedure of law. State should be responsible quickly to enact Law on Elimination of Sexual Violence, as part of country’s efforts in implementing the principles of due diligence.
Feminist Pedagogy as Interruption of Domination: Case Studies of Graduate Studies KWG UI & IKG UIN Kalijaga
Authors: Candraningrum Dewi , Dhewy Anita
Published: February 2023

Feminist pedagogy explicitly documented equal and inclusive interactions that is aware of the existence of the other in the text and practice of knowledge. Feminist pedagogy is not a tool or collection strategy, but it is a philosophy which links the theory of teaching and learning that putting feminism in its central dynamics. It accepts to be appreciated, criticized, and fought as a form of knowledge dynamics. First, it did the work of resistance against hierarchy and domination. Second, it used the experience as a source of knowledge. Third, it made a transformation and realization in arrays of critical ways. This paper investigates two studies centers: Gender Studies Graduate Program of UI (later shortened as KG UI), which was established in 1990; and Islam & Gender Study UIN Kalijaga (later shortened as IKG UIN YK) which was established in 2015. In-depth interviews are mainly done to the founders of the graduate school at the two universities, lecturers and students.