bluuebunny/crossref_metadata_2025 huggingface dataset:
Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics
Authors: Roy Arpan Narayan , Gupta Aayatti Mallick , Banerjee Deboshmita , Chakrabarti Jaydeb , Raghavendra Pongali B.
Published: October 2023

Human coronaviruses like MERS CoV are known to utilize dipeptidyl peptidase 4 (DPP4), apart from angiotensin-converting enzyme 2(ACE2) as a potential co-receptor for viral cell entry. DPP4, the ubiquitous membrane-bound aminopeptidase, is closely associated with elevation of disease severity in comorbidities. In SARS-CoV-2, there is inadequate evidence for combination of spike protein variants with DPP4, and underlying adversity in COVID-19. To elucidate this mechanistic basis, we have investigated interaction of spike protein variants with DPP4 through molecular docking and simulation studies. The possible binding interactions between the receptor binding domain (RBD) of different spike variants of SARS-CoV-2 and DPP4 have been compared with interactions observed in the experimentally determined structure of the complex of MERS-CoV with DPP4. Comparative binding affinity confers that Delta-CoV-2: DPP4 shows close proximity with MERS-CoV:DPP4, as depicted from accessible surface area, radius of gyration and number of hydrogen bonding in the interface. Mutations in the delta variant, L452R and T478K directly participate in DPP4 interaction, enhancing DPP4 binding. E484K in alpha and gamma variants of spike protein is also found to interact with DPP4. Hence, DPP4 interaction with spike protein becomes more suitable due to mutation, especially due to L452R, T478K and E484K. Furthermore, perturbation in the nearby residues Y495, Q474 and Y489 is evident due to L452R, T478K and E484K, respectively. Virulent strains of spike protein are more susceptible to DPP4 interaction and are prone to be victimized in patients due to comorbidities. Our results will aid the rational optimization of DPP4 as a potential therapeutic target to manage COVID-19 disease severity.
Pandemic Fatigue and Vaccine Hesitancy among People Who Have Recovered from COVID-19 Infection in the Post-Pandemic Era: Cross-Sectional Study in China
Authors: Qin Chenyuan , Deng Jie , Du Min , Liu Qiao , Wang Yaping , Yan Wenxin , Liu Min , Liu Jue
Published: October 2023

At present, the COVID-19 pandemic is still ongoing globally and the virus is constantly mutating. The herd immunity barrier established by past infections or vaccinations is gradually weakening and reinfections are occurring. To evaluate the pandemic fatigue and vaccine hesitancy among people who have recovered from COVID-19 in the post-pandemic era, we conducted an anonymous cross-sectional survey study in China from 4 July to 11 August 2023, nearly 6 months after the last large-scale nationwide infection. Basic sociodemographic characteristics, health-related factors (smoking, drinking, and chronic disease history), COVID-19 vaccination history, and self-reported long COVID were obtained as potential covariates. A series of logistic regression models were performed to examine the association between pandemic fatigue and vaccine hesitancy toward the next dose of COVID-19 vaccines via crude relative risks (cORs) and adjusted relative risks (aORs) with 95% CIs. According to our results, of the 2942 participants, 1242 (42.2%) were hesitant (unwilling or not sure) to receive the next dose of COVID-19 vaccines. The average score on the Pandemic Fatigue Scale was 21.67 ± 8.86, in which the scores of all items in the vaccine-hesitant group were significantly higher than those in the vaccine-accepting group. Additionally, the higher the pandemic fatigue level among people who have recovered from COVID-19, the more likely they were to be hesitant to receive the next dose of the COVID-19 vaccines (moderate: aOR = 2.94, 95% CI: 2.46–3.53; high: aOR = 6.88, 95% CI: 5.49–8.64). Overall, more than 40% of the recovered participants were unwilling or uncertain about the next vaccine dose, with varying degrees of pandemic fatigue. Pandemic fatigue is a potentially relevant factor for vaccine hesitancy and may hinder the translation of vaccination intention into behavior. Considering the ongoing reinfection situation, implementing a health education plan to reduce pandemic fatigue and prioritizing vaccination issues for people who have recovered from COVID-19 may be key to promoting the reduction of the COVID-19 disease burden and ensuring the health and well-being of the population.
An Electric Bus Battery Swapping Station Location Method Based on Global Optimized Peak Traffic Flow
Authors: Wang Yu , Lei Mingyu
Published: October 2023

The electric bus is an extremely important part of urban public transportation and has a huge impact on the ecosystem. However, the battery capacity is still a tough problem, and electric buses often face a booming demand for charging during peak periods. This paper focuses on the problem of electric bus battery swapping station (BSS) location. Based on the traffic flow assignment theory, this paper proposes a hybrid traffic assignment method based on GA and Frank–Wolfe algorithm, which has proved to be closer to the global optimum than the traditional method. This paper proposes a BSS selection model considering service quality as an evaluating indicator and a simulation is made based on a virtual road network. Compared with the traditional method, the result from the hybrid method is more suitable for electric buses when considering the situation at peak hours.
LEGAL COMPETENCE OF THE EDUCATIONAL MANAGER AND ITS FORMATION IN THE CONDITIONS OF THE MAGISTRATE
Authors: BABENKO I.
Published: October 2023

The article examines the urgent need for new approaches to the professional training of managers of educational institutions in terms of legal competence, which is emphasized by the current legislation and normative documents of the Ministry of Education and Culture of Ukraine. The advantages of using the situational approach are highlighted, which is organically connected with the activity in the process of pedagogical formation of the legal competence of the future manager in the conditions of the master's degree. The author emphasizes that not only on the basis of the study of classical law disciplines, but also on the basis of new approaches to teaching (for example, situational-activity), it is possible to successfully form the legal competence of future managers of education.

In this way, the legal competence of the manager of the second (master's) level of higher education in the specialty 073 Management "Educational Institution Management" obtained at the university should become the basis for the activities of domestic education managers, which will enable our educational institutions to reach new heights of relations with society. With the help of not only classical educational disciplines in law, but also new approaches to teaching (for example, situational-activity: case study, which is connected with activity), the possibility of active and purposeful formation of legal competence of future managers of Ukrainian education can be ensured. It should be clearly oriented to the requirements of the newest domestic market of all, without exception, educational services, precisely to the legal aspects of the professional competences of education managers, who will possess certain abilities and skills regarding their practical application in daily life, while working in managerial positions in educational institutions.
DIAGNOSTICS OF OLDER PRESCHOOL CHILDREN’S SENSITIVITY FORMATION LEVELS
Authors: HNIZDILOVA O. , STANICHENKO O. , VASHAK O.
Published: October 2023

The article covers the general issues of the organization and content of the ascertainment experiment and analyzed the results of diagnostics of the state of older preschoolers’ sensitivity formation. The criteria for choosing the diagnostic toolkit for determining the level of preschoolers’ sensitivity formation were age and individual characteristics, as well as the possibility to identify and characterize the indicators of sensitivity formation proposed by us. The toolkit included the development of a questionnaire in the form of a conversation, and the diagnostic game “Who is sensitive?” based on plot diagnostic cards; plots were developed for the organization of role-playing games “Hospital” and “Veterinary Clinic”. Characterization of the levels of older preschool children’s sensitivity formation has been carried out according to the specified criteria and indicators. We have found that, according to the cognitive criterion children of older preschool age have an average and low level of sensitivity formation. We got the highest score for the emotional-motivational criterion because children are prone to showing moral feelings. Yet, they often need additional incentives for charitable activities. And unfortunately, the results of diagnostics according to the activity-behavioral criterion also turned out to be low due to the lack of preschool children’s skills in showing sensitive attitudes toward others. The confirmatory section has proved the necessity of carrying out systematic, planned work in preschool educational institutions on preschoolers’ sensitivity formation. A confirmatory experiment to determine the initial levels of older preschool children’s sensitivity formation in the conditions of the traditional educational process in a preschool education institution according to cognitive, emotional-motivational, and activity-behavioral criteria revealed that the average and low levels of sensitivity education prevailed among children, which caused the need for the search for ways to solve this problem, in the justification and practical approbation of pedagogical conditions for the preschoolers’ sensitivity formation in the conditions of preschool educational institutions.
CURRENT STATE OF PROFESSIONAL TRAINING OF ELECTRONIC INFORMATION AND TECHNOLOGY BACHELORS IN UNIVERSITIES OF THE PEOPLE'S REPUBLIC OF CHINA
Authors: GRYNOVA M. , BUNETSKA I.
Published: October 2023

The purpose of the study is to study the state of higher education in China for professional training of bachelors of electronic information and technology. Eight main concepts for the development and modernization of education have been established. For the first time, professional knowledge and skills acquired by bachelors majoring in electronic information and technologies were characterized, and an analysis of their compliance with the National Education Standard for the relevant specialty in higher education institutions of the People's Republic of China was carried out. The obtained knowledge allows us to draw a conclusion about the organizational principles of professional training of electronic information and technology bachelors in Chinese universities.
FORMATION OF COMPETENCIES OF COLLECTIVE SOFTWARE DEVELOPMENT OF STUDENTS IN THE FIELD OF INFORMATION TECHNOLOGY IN THE PROCESS OF USING FREE SOFTWARE
Authors: KLOCHKO O. , SHARYHIN O.
Published: October 2023

The article analyzes the existing systems that provide an opportunity for collective software development by students of information technology and offers recommendations for their use in the educational process. In the authors' opinion, it is advisable to use free versions of the Atlassian stack (Jira, Bitbucket, Confluence), which allows forming professional competencies in collaborative software development of future specialists, while the limitations of free versions are not critical for educational purposes.

The concept of the competence of collective software development of an information technology specialist is formulated, by which we mean the integrated ability of an individual to effectively solve software development tasks in the process of teamwork in professional activities.

It has been found that software development requires the implementation of many steps, from defining requirements to testing and releasing a product. In the process of forming a collective software development of an information technology specialist, cloud services and other systems (Bitbucket, GitHub, GitLab, Jira, Asana, Basecamp, Mantis, Bugzilla, etc.) are used.

Training future IT professionals in the development process and involvement in real software development projects will help them acquire, develop, and improve their collaborative software development competencies.
PEDAGOGICAL HERITAGE OF ANTON MAKARENKO IN THE CONTENT OF TRAINING OF FUTURE TEACHERS OF EXTRACURRICULAR EDUCATION INSTITUTIONS
Authors: LEBEDYK L.
Published: October 2023

The article reveals the important professional aspects of using the pedagogical heritage of Anton Makarenko in designing the content of the training of teachers of out-of-school education institutions for professional activity. The author singled out the requirements for the design of the content of master's training in the specialty 011 Educational, pedagogical sciences under the educational and professional program "Out-of-School Education". The content of master's training is proposed to be built according to the modular system of education, the advantages of the modular system, effective for the training of teachers of out-of-school education institutions in the master's degree, are indicated.

The basic requirements for the structuring of the content of the training of teachers of out-of-school education institutions in the conditions of the master’s degree are highlighted: systematicity, continuity, mutual subordination, a holistic representation and perception of the entire volume of information from the module of the academic discipline, the possibility of choosing an individual educational trajectory and mastering the content of professional education, updating this content, technology educational process, ensuring productive and creative thinking, development of master's students' skills of reflective culture, activity approach.
FORMATION OF PROFESSIONAL COMPETENCE OF HIGER MEDICAL EDUCATION STUDENTS USING INTEGRATED AND BINARY LESSONS IN TEACHING CLINICAL DISCIPLINES
Authors: PINCHUK V. , DELVA M. , GRYN K. , BILKO V.
Published: October 2023

The mission of higher education institution is to support teachers in the development of pedagogical skills. This is especially relevant for the teaching staff of medical educational institutions, where it is necessary to master the method of teaching the discipline and the educational process itself, since the vast majority of teachers do not have special education.

The purpose of the study was to outline the advantages of conducting integrated and binary classes in the teaching of the discipline "Neurology" with the aim of forming the professional competence of students.

Materials and methods. Analysis of scientific and methodical literature and generalization of own practical experience of conducting classes were used in the study.

Results. Topics from the "General Neurology" module include knowledge of topical neurology: the principles of the structure and functioning of all parts of the nervous system, so the built-in interactive anatomical atlas allows students of higher medical education to improve their knowledge of human anatomy online. SECTRA anatomical tables have large interactive screens with an indication system that provides interaction with images of the human body obtained by computer or magnetic resonance imaging. Classes are conducted by two teachers, whose task is to present the studied material from different points of view: anatomical approach and clinical thinking. A significant role is played by the psychological and methodical compatibility of the teachers preparing the binary class. In the process of preparation, teachers analyze the actual material on the topic, determine the motivation of the researched topic, take into account the scope and level of students' knowledge of the disciplines, identify interdisciplinary connections between the studied disciplines, choose the most rational form of the lesson. In our own experience, the inclusion of such technologies in the educational process is an important step that expands the possibilities of assimilation of information for those seeking education. The use of this high-tech equipment in combination with clinical understanding of pathological processes significantly increases the effectiveness of providing educational services to students of higher medical education.

Conclusion. Binary classes held jointly by the teachers of the Department of Nervous Diseases and the Department of Anatomy with Clinical Anatomy and Operative Surgery of the Poltava State Medical University showed that they are of great interest to both students and teachers. Such experience contributes to a deeper and better assimilation of educational material compared to traditional forms.
OBJECTIVES AND STRATEGIC PLANNING OF THE TEACHER’S PROFESSIONAL DEVELOPMENT IN THE MODE OF TIME MANAGEMENT
Authors: SAVONOVA H.
Published: October 2023

The article analyzes the contradiction between need for a planned and systematic professional development of a modern teacher and lack of time for this process. It shows a dependence of the teacher’s professional planning process from conscious and specific goal setting and strategic planning. It’s noted that goal setting is the basis for self-management and time-management. The article proves the importance of goal setting in the teacher’s professional development, explains the methods and techniques of goal setting in time management mode. It pays attention to framing the issues of goal setting. It marks the main reasons, why the teachers waste their time, so that make them to spend their personal time on the work matters. According to these reasons it gives the recommendations on time planning. The article points, that goal setting is preceded by an analysis of the accumulated cases and determination of their importance by the teacher himself, and goal setting itself begins with open questions and is carried out using SMART technology.
UPDATE OF THE EXPERIENCE OF ORGANIZING LEGAL EDUCATION OF OFFICERS IN HIGHER MILITARY EDUCATION INSTITUTIONS OF UKRAINE: A COMPETENT APPROACH
Authors: CHERNYSH N. , ILCHENKO O.
Published: October 2023

This article offers a comprehensive analysis of viable tactics for integrating legal education into higher military education in Ukraine in a creative manner. The central objective is to leverage a competency-based methodology to equip officers with the necessary skills and knowledge to execute their legally mandated professional duties competently. The authors posit that this approach is highly efficacious in achieving favorable outcomes. The article emphasizes the importance of utilizing interactive teaching methods, independent work of cadets, and extracurricular activities related to legal education. These approaches contribute to the efficient acquisition of relevant knowledge and skills. In order to enhance the competencies of officers, it is highly recommended to adopt positive practices that are interactive in nature. Some of the most effective methods include incorporating business games, conducting case studies, and utilizing training exercises. Additionally, it is highly beneficial to involve legal professionals in the teaching process, as they can provide valuable insights and expertise. By implementing these strategies, officers can develop their skills and knowledge base, ultimately leading to improved performance and success in their roles. The research findings confirm that the experience of implementing legal education for officers in a higher military school in Ukraine encompasses valuable examples that support the implementation of competency-based principles. These positive practices foster the development of necessary skills and knowledge in the field of military law, equipping officers to address legally regulated situations during their service. In summary, the article explores the potential of the competency-based approach in organizing the legal education of officers in a higher military school in Ukraine.  This article provides recommendations for the use of interactive methods and the involvement of legal professionals in the educational process, aiming to enhance the preparation of military experts in the field of military law and ensure their successful performance during service.
FEATURES OF THE IMPLEMENTATION OF PRACTICES IN THE PROFESSIONAL TRAINING SYSTEM OF FUTURE ENVIRONMENTALS
Authors: SHKURA T. , DIACHENKO-BOHUN M. , HOMLIA L. , ORLOVSKYI O. , ROKOTIANSKA V.
Published: October 2023

The article is devoted to the analysis of the role of educational and production practices in the system of practical training. Students' practice involves the continuity and sequence of its implementation while obtaining the necessary and sufficient amount of practical knowledge and skills necessary for future work. It was established that mastering modern methods, forms of organization and tools of work in the field of their future profession will highly effectively contribute to the formation of students' professional skills and abilities for making independent decisions during specific work in real market and production conditions, fostering the need to systematically renew their knowledge and creatively apply them in further practical activities.

It is recognized that the implementation of practices in real-time conditions cannot be compared in terms of efficiency and effectiveness with practices implemented using distance learning methods, but taking into account the challenges of today, the use of distance technologies is the optimal way to fully implement the training of a highly professional ecologist.
O emprego de tropa de choque e a prisão em flagrante em massa
Authors: Ferreira Fábio Bonifácio , Rocha João Pedro Passos
Published: October 2023

A Constituição Federal de 1988, em seu art. 5º, IV e XVI, assegura a reunião de cidadãos para manifestação de um pensamento coletivo. O preceito normativo garante o direito fundamental exigindo apenas a prévia comunicação e a vedação ao porte de armas para realização de um ato pacífico. Pode ocorrer, no entanto, que a ordem pública desejada seja perturbada em eventos multitudinários. As polícias militares, responsáveis pela polícia ostensiva e pela preservação da ordem pública, precisam estar preparadas para atuar em respeito a dignidade da pessoa humana. Por isso se especializaram criando unidades de choque que possuem um protocolo bem estabelecido de atuação em respeito aos direitos fundamentais, notadamente baseado na técnica policial de dispersão. Em torno dela não há que se falar em prisão em massa. Contudo, episódios recentes mostraram uma postura distinta em que forças de Estado realizaram a prisão de multidões. Buscou-se entender sob o prisma dos princípios da exteriorização e da responsabilidade pessoal, específicos do direito penal, se os protocolos de atuação devem ser modificados a fim de contemplar a possibilidade jurídica dessa condução pela simples participação na manifestação sem uma individualização da conduta desviante.
Perception Survey and Course Design on Death
Education
Authors: JIN Myung Ho , LEE Hai-Woong , KIM Seon Kyoung
Published: October 2023

This article reports on a survey that was conducted on students and professors at
a college of Korean medicine on attitudes toward death and the need for death
education. Survey results show a high demand among participants for death
education, including education about facing death in clinical practice as a
medical professional. In light of the results of this survey, we propose a
semester-long death education course and hope that this recommendation will be
helpful for implementing and developing death education at medical schools of
Korean medicine.
The presence of local captures of the myocardium of the pulmonary veins after radiofrequency isolation improves the outcome of treatment in patients with paroxysmal atrial fibrillation
Authors: Bazylev V. V. , Kozlov A. V. , Durmanov S. S.
Published: October 2023

Aim. To study how the presence of local capture (LC) after pulmonary vein (PV) isolation affects the effectiveness of radiofrequency ablation (RFA) in patients with paroxysmal atrial fibrillation (AF)

Methods. The study was a single-center, observational, prospective study. The total number of 186 patients. All patients underwent RFA PV for paroxysmal AF. During the operation, the activity of PV and the presence of LC were assessed. Patients in whom LC after PV isolation occurred in at least one PV were included in the first group; patients in whom LC were absent - in the second group. The first group - 98 patients, the second group - 88. Patients in the groups did not statistically differ in the main indicators - weight, gender, age, duration of anamnesis, left atrium volume and ejection fraction, as well as in the presence of concomitant pathology. The duration of the operation, the time of RFA and time fluoroscopy between the groups also did not differ statistically.

Results. Mean observation time for patients was 374.4±25,.2 days. In the first group, sinus rhythm was maintained in 82 patients out of 98 (83,7%), in the second group 60 patients out of 88 (68.2%). The difference is statistically significant odds ratio 2.392 (95% confidence interval 1.189 - 4.816, p=0.031).

Conclusion. The presence of local captures of the myocardium of the pulmonary veins after radiofrequency isolation is associated with an improvement in the results of treatment of patients with paroxysmal AF.
Evaluation of efficacy and identification of predictors of recurrence in patients after pulmonary vein cryoballoon ablation
Authors: Avanesyan G. A. , Filatov A. G.
Published: October 2023

Aim. To evaluate the effectiveness and identify predictors of recurrence after pulmonary veins (PV) cryoballoon isolation patients with atrial fibrillation (AF).

Methods. In total, the study included 100 patients who met the selection criteria. Depending on the form and duration of AF paroxysms documented by ECG and Holter monitoring, patients were divided into two groups. The first group included 57 patients with paroxysmal AF (57%), and the second group included 43 patients with persistent AF (43%).

Results. As a result of our study, important achievements of the greatest efficiency during cryoballon ablation were identified: isolation of all PV; achievement of the “input-output” block (elimination of spike activity according to the diagnostic electrode in the PV during appplication), which was recorded at a temperature of -30 and more °C; the minimum appplication time is 180 sec after reaching the entry-exit block. An electroanatomical diagram of the left atrium with a high frequency of left atrium and PV activity in patients with paroxysmal and persistent forms of AF was developed. Nine zones with pronounced activity were identified, more pronounced zones with low-amplitude activity in patients with persistent AF. The multivariate Cox analysis showed predictors, an exceptional effect on the risk of AF recurrence after cryoballoon ablation: the presence of diabetes mellitus led to the risk of AF recurrence by 2.39, incomplete isolation of the PV by 3.98 times, the value of left atrial volume index ≥ 61.9 ml/m2 in 2.91 times, peak atrial longitudinal strain value of left atrium ≤29.3.

Conclusion. The results of the study allow us to determine the criteria for high efficiency during cryoballoon ablation, as well as a high-risk group for relapse. When selecting patients for cryoballoon control of PV coronavirus, with the achievement of a greater one, possible factors should be considered: indexed volume of left atrium according to multispiral computed tomography, peak atrial longitudinal strain value of left atrium, absence of diabetes mellitus.
Investigation of Bax and Phospho-Tau Protein Expression in Preeclampsia Placenta
Authors: KAYA Seval , AŞIR Fırat , AYAZ Hayat , AĞAÇAYAK Elif , DEVECİ Engin
Published: October 2023

Background: Preeclampsia is a pregnancy complication with a high morbidity and mortality rate.BAX is a proapoptotic protein and in recent years, 14-3-3 tau proteins are considered as key regulators of many processes, such as apoptosis. In this study, we investigated the expression of phospho-tau and Bax in preeclampsia apoptosis immunohistochemically.
Materials and Methods: 25 healthy and 25 preeclamptic pregnant placentas were included in the study. Placental samples were fixed with 10% neutral buffered formalin. Routine paraffin wax tissue protocol was used.
Results: According to histological micrograf, the trophoblastic cells in the villi were normal in the control group. Mild dilatation in blood vessels was seen. Hyalinized and necrotic areas in chorionic villi and an increase in fibrinoid tissue in root villi were detected in preeclampsia sections. Phospho-tau and Bax primary antibodys were used for immunohistochemical evaluation. The sections from of the preeclampsia group were highly positive for syncytiotrophoblasts and villous connective tissue. It was also statistically different from the control group (p<0.05).
Conclusions: When we evaluate the results shows that Phospho-tau and Bax may be determinant proteins in the apoptosis pathway of preeclampsia.
Navigating Additional Language Pedagogical Innovation: An Ecological Perspective on a Novice Teacher’s TBLT Implementation in China
Authors: Coss Matthew
Published: October 2023

Language teachers’ ability to be “change agents” (Van den Branden, 2016) and engage in pedagogical innovation is constrained by internal and external forces, including existing beliefs, institutionalized practices, and socio-political forces (Carless, 2013). This article offers an expanded framework to more comprehensively understand the many factors affecting teachers’ willingness and ability to innovate. I used a focal participant case study approach to explore a novice language teacher’s experience implementing Task-Based Language Teaching (TBLT), in China. Data were generated via a semi-structured interview and recursively coded inductively and deductively. Using a multi-level, nested ecological framework (Chong et al., 2022; Douglas Fir Group, 2016), I assert that teachers’ engagement in and with innovation is facilitated and constrained on micro-, meso-, and macro-levels. Teachers’ innovation potential is dependent on access to a network of “meaningful others” (Van den Branden, 2022), which, in the present study, included institutional stakeholders, expert mentors, and empirical research. I conclude that teachers’ decisions to pursue or abandon a particular educational innovation (e.g., TBLT) is based on a complex network of internal and external facilitators and constraints, and understanding these factors and their inter-relationships is critical for a comprehensive evaluation of the (successful or failed) implementation of educational innovation.
Diagnósticos de Enfermagem a partir de narrativas de pessoas vivendo com HIV/AIDS em Guiné-Bissau
Authors: Sanca Amiry Monteiro , Graeff Murilo dos Santos , Cordova Fernanda Peixoto , Riquinho Deise Lisboa , Almeida Miriam de Abreu
Published: October 2023

Objetivo: identificar e analisar os diagnósticos de Enfermagem mais frequentes de pessoas vivendo com HIV/aids em atendimento ambulatorial em Guiné-Bissau por meio de suas narrativas. Método: trata-se de uma análise secundária dos dados de um estudo com abordagem qualitativa, cujos participantes foram 16 pessoas vivendo com HIV/aids. Para identificar os diagnósticos de Enfermagem, foi utilizado o Processo Diagnóstico, que é um processo intelectual complexo na aplicação do Pensamento Crítico. Resultados: havia 16 participantes, sendo 12 do sexo feminino, e a mediana de idade foi de 33,5 anos. A partir das narrativas dos participantes, foram identificados 26 diferentes diagnósticos de Enfermagem, dos quais 10 tiveram frequência igual ou superior a 10%. Os 10 diagnósticos mais frequentemente identificados pertencem aos seguintes domínios: autopercepção; enfrentamento/tolerância ao estresse; promoção da saúde; conforto; percepção/cognição; e papéis e relacionamentos. Embora os diagnósticos identificados com significado mais positivo tenham aparecido em 50% dos participantes (disposição para o autoconceito melhorado e disposição para cuidado da saúde melhorado), as narrativas também indicaram que o processo de viver com HIV/aids tem sido bastante desafiador para o guineenses participantes no estudo, com presença de diagnóstico de risco de dignidade humana comprometida (50% dos participantes) e resiliência prejudicada (43,7% dos participantes). Conclusões: os diagnósticos de Enfermagem mais frequentes das pessoas vivendo com HIV/aids participantes deste estudo foram: disposição para autoconceito melhorado; risco de dignidade humana comprometida; e disposição para cuidado da saúde melhorado. Implicações para a prática de Enfermagem: na assistência de Enfermagem, é fundamental a implementação integral do Processo de Enfermagem, pois, dessa forma, a prestação de cuidados não ocorre apenas na esfera biológica, mas também na promoção de cuidados que atendam às necessidades dos pacientes, visando mais dignidade, cidadania e qualidade de vida.
Development of an electron track-structure mode for arbitrary semiconductor materials in PHITS
Authors: Hirata Yuho , Kai Takeshi , Ogawa Tatsuhiko , Matsuya Yusuke , Sato Tatsuhiko
Published: October 2023

Optimizing the design of semiconductor detector requires an electron track-structure code that can trace an incident electron motion with energies down to a few eV and simulate the production process of excited electrons in semiconductors. We therefore developed an Electron Track Structure mode applicable to ARbitrary Targets (ETSART) and implemented it into Particle and Heavy Ion Transport code System (PHITS). ETSART can simulate the electrons’ motion in arbitrary semiconductor materials using their bandgap energies. The accuracy of ETSART was validated by comparing the calculated electron path lengths in semiconductor materials with the corresponding data in the ICRU Report 37. Using ETSART, we also computed the mean energy required to produce an electron–hole pair (epsilon value) in various semiconductors and found that the epsilon value varies nonlinearly with the bandgap energy. Thus, ETSART can be useful for initial and mechanistic evaluations of electron–hole pair formation in new materials.
ANALISIS FAKTOR RESIKO PRE EKLAMPSIA BERAT PADA IBU HAMIL DI BLUD RSU KOTA BANJAR
Authors: Supriyatun
Published: October 2023

Maternal and child health services are a major priority in Indonesia's health development because there is still a significant problem with maternal mortality and morbidity. A measure of health is the Maternal Mortality Rate (MMR). 2015 saw an MMR of 305 per 100,000 live births in Indonesia. MMR reduction to 183 per 100,000 live births by 2024 and to less than 70 fatalities per 100,000 live births by 2030 is a global SDG target. Pregnancy-related hypertension is currently the leading cause of death in Indonesia. When proteinuria is absent and other organs are also affected by severe preeclampsia, blood pressure is >160/110 mmHg at >20 weeks of gestation. Preeclampsia's specific etiology is unknown as of right now. Preeclampsia in pregnant women can be caused by a number of variables, including low education levels, overworked mothers, primiparity or grande multiparity, and birth spacing that is either too near or too far apart. This study was conducted at BLUD RSU Banjar City with the aim of identifying the risk factors for severe pre-eclampsia in pregnant women. Correlational or association research, a retrospective study with a cross sectional design, is this kind of investigation. 614 pregnant women make up the study's population, which was chosen at random to create a sample size of 61. The findings revealed no relationship between educational factors (p-value: 0.394), employment (p-value: 0.664), parity (p-value: 1.000), and the time between pregnancies (p-value: 0.835; greater than 0.05) and the incidence of severe pre-eclampsia in pregnant women at BLUD RSU Banjar City. The frequency of severe pre-eclampsia in pregnant women at BLUD RSU Banjar City is not significantly correlated with education, occupation, parity, or pregnancy spacing.
FAKTOR RISIKO ACNE VULGARIS PADA REMAJA PELAJAR SEKOLAH MENENGAH PERTAMA
Authors: Salsabila Samara Shafira , Salshabira Syafira , Sukmayanti Zanastia , Nisa Hoirun
Published: October 2023

Acne vulgaris merupakan gangguan kulit yang sebagian besar dialami oleh remaja. Penelitian ini bertujuan untuk mengetahui faktor risiko kejadian Acne vulgaris pada remaja di SMPN 120 Jakarta Utara. Penelitian ini merupakan penelitian analitik dengan desain studi cross-sectional. Data dikumpulkan dari 290 responden yang dipilih dengan teknik simple random sampling. Data dikumpulkan menggunakan kuesioner yang diberikan secara online. Analisis data dilakukan dengan uji Chi-square, T-independen, dan regresi logistik. Hasil analisis multivariat menunjukkan bahwa terdapat hubungan antara kejadian Acne vulgaris dengan usia (Nilai p= 0,000, OR 1,704 95% CI: 1,266–2,293), riwayat keluarga (p-value 0,000, OR 3,103 95% CI: 1,755–5,486), jenis kulit (Nilai p= 0,002, OR 2,343 95% CI: 1,377–3,987), dan waktu berangkat tidur (Nilai p=0,048, OR 1,942 95% CI: 1,005–3,753). Penelitian merekomendasikan untuk memberikan edukasi pencegahan Acne vulgaris khususnya terkait kualitas tidur dengan menjaga waktu tidur untuk mengontrol hormon androgen agar produksi sebum tidak berlebihan. Penelitian ini juga menyarankan pada remaja yang memiliki jenis kulit berminyak dan riwayat keluarga berjerawat untuk lebih memperhatikan kebersihan wajah karena memiliki risiko lebih tinggi untuk mengalami Acne vulgaris.

Kata kunci: Acne vulgaris, faktor risiko, remaja
PENGARUH GUIDED IMAGERY TERHADAP ANSIETAS PADA IBU HAMIL
Authors: Kusumasari Dilla , Fanani Mohammad , Septiawan Debree
Published: October 2023

Ansietas sering ditemukan pada ibu hamil dengan tingkatan yang berbeda pada setiap wanita. Tujuan penelitian ini adalah untuk menganalisis guided imagery terhadap ansietas pada ibu hamil di poli rawat jalan Obstetri RSUD Dr. Moewardi, Surakarta. Penelitian ini bersifat eksperimental, menggunakan rancangan penelitian experimental pretest–posttest control group design. Pengambilan sampel dilakukan secara purposive sampling. Data yang diperoleh ditabulasi dan dianalisis untuk mengetahui perbedaan antara kelompok perlakuan (guided imagery) dan kelompok kontrol (terapi standar), dengan analisis uji t berpasangan bila distribusi data normal, dan uji Wilcoxon bila distribusi data tidak normal. Perbedaan data dicatat sebagai signifikan apabila nilai p menunjukkan < 0,05. Hasil penelitian menunjukkan bahwa guided imagery berpengaruh terhadap ansietas pada ibu hamil, dimana terjadi penurunan skor rerata Hamilton Anxiety Rating Scale (HARS) pre-posttest yang signifikan dengan nilai p = 0,000 (p < 0,05). Penelitian ini menunjukkan bahwa guided imagery berpengaruh menurunkan ansietas pada ibu hamil

Kata Kunci: ansietas, guided imagery, kehamilan
Ansiedad, depresión y bienestar espiritual en estudiantes universitarios durante el confinamiento por COVID-19
Authors: Ríos Rosado Norma Lizet , Jiménez Ortiz José Leonardo , Frutos Nájera Daniela Guadalupe , Flores Laguna Omar Arodi , Quiyono Escobar Esteban , Islas Valle Rosa María
Published: October 2023

Introducción: La pandemia por COVID-19 amenazó la salud física de la población y afectó la salud mental, debido al encierro en el confinamiento y a la pérdida de relaciones sociales diarias.
Objetivo: Determinar el nivel de ansiedad, depresión y bienestar espiritual en estudiantes universitarios durante el confinamiento por COVID-19.
Metodología: Se realizó un estudio observacional, descriptivo y transversal con estudiantes universitarios en México, bajo muestreo probabilístico aleatorizado, mediante la aplicación de Hospital Anxiety and Depression Scale y Spiritual Well-Being Scale. El análisis de datos fue no paramétrico.
Resultados: Participaron 364 estudiantes con edad promedio de 20 años y desviación estándar ±3,37, predominando las mujeres (205), solteros (353), mexicanos (317), que cursaban el tercer año (151), en área de salud (133). Del total, 44.8% (163) no presentaron ansiedad, 16.5% (60) fue caso dudoso y 38.7% (141) caso significativo. 74.4% (271) no presentaron depresión, 15.7% (57) fue caso dudoso y 9.9% (36) caso significativo. El nivel de bienestar espiritual se estableció en 10.44% (38) bajo; 44.78% (163) moderado y 44.78% (163) alto. Respecto a la ansiedad, se encontró asociación estadísticamente significativa relacionada al sexo (p=0.013); en la depresión en cuanto a nacionalidad (p=0.038) y para el bienestar espiritual en cuanto a sexo (p=0.023) y facultad (p=0.001).
Conclusión: Más de la mitad de los estudiantes presentaron ansiedad en diferentes niveles, la mayoría no presentó depresión y nivel de bienestar espiritual moderado y alto. Indagar sobre ansiedad, depresión y bienestar espiritual con los instrumentos empleados, parece ser un método accesible y confiable.
Anticandidosis activity of aqueous and ethanolic extracts of Harungana madagascariensis, Zanthoxylum leprieurii and Xylopia aethiopica
Authors: Marcel Ahon Gnamien , Sitapha Ouattara , Elisée Kporou Kouassi , Joel Akakpo Akue Moevi , Marcellin Tiemoko Kouassi , Mathieu Kra Adou Koffi , Joseph Djaman Allico
Published: October 2023

Some ailments have been cured either by the use of plant parts or by mixing different plant parts (recipes). It is with this in mind that this study originated, focusing on the valorization of plants from the African pharmacopoeia. Thus, the activity of single extracts and aqueous and hydroalcoholic mixtures of the bark and leaves of Harungana madagascariensis, the bark of Zanthoxylum leprieurii and the fruit of Xylopia aethiopica was evaluated on the in vitro growth of Candida strains (Candida albicans 18650 and Candida albicans 18792 and Candida glabrata). Antifungal tests were carried out by plating 1,000 cells of each fungal germ on Sabouraud agar medium using the double dilution slant tube method. Deth70% extract inhibited the growth of Candida albicans 18650 and Candida albicans 18792 at an FMC value of 25 mg/mL, and Candida glabrata at an FMC value of 50 mg/mL. Phytochemical screening revealed the presence of chemical compounds such as polyphenols, flavonoids, saponosides, gallic and catechic tannins and the absence of sterols.
FPGA Implementation of Efficient CDF-9/7 Discrete Wavelet Transform
Authors: C Roopa K. , S Chetan
Published: October 2023

Architecture CDF-5/3 DWT is utilized to derive CDF-9/7 DWT. Because of the prevalence of fractional parts in the generic CDF 9/7 architecture and the occurrence of truncation errors, the design is difficult to execute. Since the CDF-5/3 DWT filter allows for the employment of merely a shifter, attempted to design the CDF-9/7 DWT filter in this manner so that the truncation error is as little as possible, if not eliminated.
Anesthetic Management of Unexpected Retroperitoneal Paragonglioma: Case Report
Authors: Ennaoui Asmaa , Haddougua Sara , Mourouth Hanane , Zerrouki Youssef
Published: October 2023

Paragangliomas are rare tumors that arise from extra-adrenal chromaffine cells. Paraganglioma are classed as functional or non functional based on production of catecholamines, similar pheochromocytoma the clinical presentation is non- specific. We present a case perioperative anesthesic management of accidental intra-operatively diagnosed precave paragonglioma wich was confirmed as pheochromcytoma. A 48 women presented paroxysms of hypertension and adrenergic symptoms including classic triad of episodic headache, sweating, and tachycardia. Abdominal sonography detected an adrenal mass; Surgical treatment is the only radical treatment. Histological examination of the surgical specimen revealed a paraganglioma.
Primary Carnitine Deficiency: Rare Cause of Paediatric Dilated Cardiomyopathy, Often Underdiagnosed
Authors: Filali Imane , Hmimidi Ikrame , Aouraghe Hanae , Bentahila Abdelali
Published: October 2023

Primary carnitine deficiency (PCD) is an autosomal recessive disorder of fatty acid beta-oxidation. Which results from a defect in the transport of carnitine and is one of the rare treatable etiologies of metabolic cardiomyopathies. Affected patients may present with acute metabolic decompensation in infancy or severe cardiomyopathy in childhood. There have also been reports of dramatic sudden infant death syndrome. Early disease detection and treatment with L-carnitine can be lifesaving. We present in this report, a severe case of decompensation of previously undiagnosed dilated cardiomyopathy in a 14-year-old boy, who presented to the pediatric emergency department with acute heart failure, initially suspected to be viral myocarditis. Chest x-ray showed cardiomegaly, echocardiographic findings included hypokinetic dilated cardiomyopathy with reduced ejection fraction at 22%, the respiratory multiplex PCR came back in favor of a SARS-CoV-2 infection, Laboratory test results showed hepatic failure and a low rate of free and total plasma carnitine. His clinical condition deteriorated rapidly, with the onset of cardiogenic shock leading up to his death in the intensive care unit before carnitine therapy was initiated. The aim of this case report is to highlight the importance of searching for a metabolic cause, particularly primary carnitine deficiency, for early treatment and improved prognosis of the disease.
Prevalence of Glucose 6 Phosphate Dehydrogenase Deficiency in Population of Gujarat - Report of 9184 Cases
Authors: Patel Arpita , Shah Aashka , Patel Riddhi , Shah Hiral , Jariwala Tulsi , Lakdawala Sheel , Desai Ms Shreya
Published: October 2023

Background: All humans have the Glucose 6 phosphate dehydrogenase gene. Some people are born with a mutation of the Glucose 6 phosphate dehydrogenase gene. Most of these individuals are asymptomatic but may exhibit non-immune hemolytic anemia, even severe anemia in response to exposure to certain environmental triggers, most commonly, infection or exposure to certain foods like fava beans (favism), medications or chemicals. G6PD deficiency is an X-linked disorder that primarily affects males. Heterozygous females do not usually develop severe hemolytic anemia due to G6PD deficiency. This study destined to reveal the prevalence of G6PD deficiency in south Gujarat population. Methods: This is a retrospective case study designed to assess the prevalence of G6PD deficiency in gujarat population, for patient requesting G6PD test at multiple collection center of Desai metropolis laboratory pvt ltd. between January 2022 to May 2023. Glucose-6-phosphate dehydrogenase deficiency analysis was done by Methylene dye blue test (Arkray MBK) – Qualitative method. All G6PD deficient patient confirmed by G6PD-quantitative (Kinetic method). Results: Total 9180 patients (5790 male and 3394 female) were included in this study. They were subsequently categorized into various subgroups and analysed properly. The incidence of G6PD deficiency in the selected sample frame of cases was 3.69 %. In which 4.11% of G6PD deficient cases belong to the male while the rest 2.98 % belong to the female. Conclusion: Therefore, to conclude whenever clinical and hematological findings raise the suspicion of glucose 6 phosphate dehydrogenase deficiency, the disorder should be confirmed by quantitative/quantitative measurement of red blood cell enzyme activity in both male and female. There is also need for a large screening programme, especially in malaria endemic zones.