bluuebunny/crossref_metadata_2025 huggingface dataset:
Production of Limonoids Through Callus and Cell Suspension Cultures of Chinaberry (Melia Azedarach L.)
Authors: Rind Nadir Ali , Rind Khalid Hussain , Dahot Muhammad Umar , Faiza Hafiza , Aksoy ÖZlem , Rind Khalid Hussain , Shar Akhtar Hussain , Ullah Hidayat , Jatoi Ashique Hussain
Published: June 2021

To study the in vitro production of limonoid contents through callus and cell suspension cultures of chinaberry (Melia azedarach L.) in different explants were inoculated in Murashige and Skoog (MS) medium for the callus induction with various plant growth regulators (PGRs) separately as well as in combinations. The highest callus induction (73.3%) was observed in nodular stem sections and further callus was subcultured for multiplication and finally transferred to cell suspension medium. The optimized parameters for the production of total limonoids were adjusted and UV-visible spectrophotometer was used to quantify total limonoids at 577 nm. Production of total limonoids through callus cell suspension cultures on the optimized medium was highest (141.7 μg/ml) followed by other sources like KH2PO4 (0.1 g/l) extra supplementation with optimized medium produced (138 μg/ml). Plant callus cell suspension cultures through optimized medium may be considered as a good source for the production of bio-products and its purified form could be used as a medicinal sources.

Bangladesh J. Bot. 50(2): 301-309, 2021 (June)
Efficacy of Chemical Fungicides and Plant Extracts Against Anthracnose Pathogens of Capsicum Frutescens L.
Authors: Rony Md Abu Raihan , Hosen Sarowar , Bashar MA
Published: June 2021

To evaluate the in vitro antifungal activity of five fungicides viz., Capvit 50 WP, Contaf 5 EC, Greengel 72 WP, Knowin 72 WP and Score 250 EC as well as five plant extracts viz., Acalypha indica L., Azadirachta indica A. Juss., Heliotropium indicum L., Lippia alba L. and Magnolia champaca L. at different concentrations were selected against Colletotrichum dematium and C. gloeosporioides following poisoned food technique. Among the five fungicides, Capvit 50 and Score 250 showed the complete growth inhibition of C. dematium whereas Contaf 5 EC showed the complete growth inhibition of C. gloeosporioides at all the concentrations. Contaf 5 was found as the most effective inhibitor against C. dematium. On the other hand, Knowin 72 and Score 250 were found as the most effective fungicides against C. gloeosporioides. A. indica and L. alba showed highest radial growth inhibition of C. dematium and C. gloeosporioides at 20% concentration. Moreover, A. indica and M. champaca also showed desired growth inhibition of the test pathogens. This study paves the way for the management of C. dematium and C. gloeosporioides causing anthracnose disease of chilli.

Bangladesh J. Bot. 50(2): 437-440, 2021 (June)
Potential strategies to reduce inappropriate prescribing and dispensing of antimicrobials in Bangladesh building on the experiences in other developing countries
Authors: Haque Mainul , Godman Brian
Published: June 2021

Abstract not available

Bangladesh Journal of Medical Science Vol.20(4) 2021 p.700-706
Role of cytokines in Granulomatous Colitis
Authors: Basu Keya , Sarkar Sucharita , Karmakar Subhrajyoti , Das Dipan , Das Chhanda , Sarkar Rajib
Published: June 2021

Background: Intestinal tuberculosis (ITB) have significant immunological similarity with Crohn’s disease (CD). T helper cells and various cytokines secreted by them play a very crucial role in the pathogenesis of both the diseases. It is of great clinical relevance in a country like India to perform a comparative study between CD and ITB with respect to pathogenesis.

Objectives: To study the levels of four cytokines(IL-4,IL-17, IFN-ϒ & TGF-β1 ) s in serum of patients with CD & ITB which indirectly reflects the levels of CD4+ T cells.

Material and method: An observational, cross-sectional study was done on patients, attending Gastroenterolory clinic in a tertiary care hospital, with features of ileitis, colitis or ileo-colitis due to CD or ITB.12 cases of Crohn’s disease & 13 cases of intestinal tuberculosis were taken( control-20 cases). 5 biopsies were taken from the ulcerated mucosa & 3 biopsies were taken from normal mucosa. H & E study & serum levels of four cytokines(IL-4,IL-17, IFN-ϒ & TGF-β1 ) were estimated.

Results & analysis: In CD & ITB we found marginal increase of IFN-ϒ & TGF-β1 compared to control. IL17 level was found decreased in ITB compared to control (p=0.001).CD4+ T cells study by ELISA also showed significant increase in the concentration of IFN-γ (p=0.007) in ITB. There was no change in IL4 levels.

Conclusion: Cytokines have an important role in the pathogenesis of grannulomatuos inflammatory bowel diseases. The identification of cytokines & their role in the pathogenesis might be helpful for future therapy based on cytokines, and anti-cytokine antibodies.

Bangladesh Journal of Medical Science Vol.20(4) 2021 p.784-789
Potential Drug Target Identification in Porphyromonas gingivalis using In-silico Subtractive Metabolic Pathway Analysis
Authors: Sao Prachi , Chand Yamini , Kumar Atul , Singh Sachidanand
Published: June 2021

Introduction: Porphyromonas Gingivalis (P. gingivalis) a primary periodontal disease pathogen. This bacterium affects sub-gingival tissue and leads to loss of teeth and alveolar bone destruction in the acute stage. In recent years, P. gingivalis is often connected with other diseases such as rheumatoid arthritis, diabetes, Alzheimer’s, and heart disease, though the aetiology is still unclear.

Objective: The use of commonly available drugs to treat periodontitis results in various side effects, in particular multi-drug resistant strains. As the development of multidrugresistant strains frequently urges the identification of novel drug targets, the aim of this study is to identify specific targets in the narrow spectrum to combat oral pathogens.

Methodology: This study used a comparative and subtractive pathway analysis approach to identify potential drug targets specific to P. gingivalis.

Results: The in-silico comparison of the P. gingivalis and Homo sapiens (H. sapiens) metabolic pathways resulted in 13 unique pathogen pathways. A homology search of the 67 enzymes in the unique bacterial pathway using the BLASTp program against the Homo sapiens proteome resulted in fifteen possible targets that are non-homologous to the human proteome. Thirteen genes among 15 potent target encoders are key DEG genes indispensable for P. gingivalis’s survival. A comprehensive analysis of the literature identified three potential therapeutic drug targets.

Conclusions: The three most relevant drug targets are Arabinose-5-phosphate isomerase, UDP-2,3-diacylglucosamine hydrolase, and Undecaprenyl diphosphatase. Upon corroboration, these targets may give rise to narrow-spectrum antibiotics that can specificallytreat thedental infection.

Bangladesh Journal of Medical Science Vol.20(4) 2021 p.887-896
Induced lactation case report:The journey to attain mahram relationship
Authors: Mohamad Noraini , Sulaiman Zaharah , Ismail Tengku Alina Tengku
Published: June 2021

Induced lactation is a process of producing breast milk in non-puerperal women. There are various reasons for adoptive mothers to breastfeed their adopted child through induced lactation method. For Muslim communities, the main motivating factor for an adoptive mother to breastfeed their adopted child is to establish a mahram relationship. The mahram relationship allows the adopted child to interact with other family members as if they are biologically related. The mahram relationship is achieved when adoptive mothers give breastmilk to the adopted child aged less than two years old for at least five satisfying feedings. In this paper we report the journey of two women who went through the induced lactation process in order to achieve mahram relationship with their adopted infant. In both cases, the mothers were finally able to produce milk, feed their adopted infant and reach mahram relationship.

Bangladesh Journal of Medical Science Vol.20(4) 2021 p.918-922
Comparative study on proximate and mineral composition of native and hybrid pangas (Pangasius pangasius, P. hypophthalmus) at raw and fried stages
Authors: Jahan Sadia , Habib AHM Shafiullah , Islam Shanzida , Hasan Md Kamrul , Begum Mohajira , Bardhan Shekrite
Published: June 2021

A study was conducted on the proximate and mineral composition of native and hybrid pangas, namely Pangasius pangasius and Pangasius hypophthalmus at raw and fried stages between January and December 2017. At the raw stage higher amount of average protein (23%) found in native pangas compared to hybrid (19.7%) and hybrid pangas contain higher fat (15.95%) compared to native (12.75%), although the moisture content was the same in both. Protein and fat were higher in both fishes at 26.8% and 20.95% in natives and 24.05% and 24.2% in hybrids at the fried stage. At the raw stage, mineral contents were higher in natives and the highest content was sodium (185.38 mg/100 g) followed by phosphorus (166.90 mg/100 g) and calcium (116.35 mg/100 g) and slightly decreased those minerals at the fried stage of the same fish. In the fried stage, mineral contents were found almost the same, although calcium, magnesium, iron was slightly varied and phosphorus, sodium found high in amount. But energy level was higher (328 Kcal) in hybrids compare to native. Thus, the study of raw and fried stages indicates that native pangas are better in proximate and mineral composition than the hybrids, but the energy was high in hybrids.

J. Asiat. Soc. Bangladesh, Sci. 47(1): 13-22, June 2021
Role of Exercise Echocardiography to Predict Coronary Artery Disease
Authors: Biswas Pallob Kumar , Khaled Fakhrul Islam , Parvin Tanjima , Mahmood Manzoor , Osmany DMM Faruque , Bhowmik Goutom Chandra , Mostofa ABM Golam , Singha Chayan Kumar , Kabir Ahasanul , Banerjee Sajal Krishna , Ahmed Chaudhury Meshkat
Published: June 2021

Background: Coronary artery disease (CAD) is predicted to be the most common cause of death globally. Early detection of coronary artery disease and adequate management can reduce CAD related morbidity and mortality. Various non-invasive procedures have been developed to diagnose CAD. Stress echocardiography, myocardial perfusion (SPECT) and cardiac MRI are accepted as useful tools for evaluation of inducible myocardial ischaemia in intermediate risk group patient documented by pre test probability. Among them exercise echocardiography is a remarkable physiological, safe, feasible and cost effective. Objective: To see the role of exercise echocardiography to predict CAD. Materials and methods: This cross sectional study was conducted in University Cardiac Center (UCC), BSMMU. This study include the patients who are appointed for exercise tolerance test (ETT). Echocardiographic wall motion study was recorded at rest and after peak exercise and analyzed to diagnosis the regional wall motion abnormality. Specific CAD was confirmed by coronary angiogram. Results: A total of 40 patients were included in the study from the patients who are appointed for ETT. Patients diagnosed as CAD has the mean age of 50.6 ± 9.7 years and majority of the patients were male (72.5%). Sensitivity, specificity, positive predictive value and negative predictive value of exercise echocardiography were 85.5%, 76.9%, 88.5% and 71.4% respectively in predicting coronary artery disease by exercise echocardiography. The predominant risk factors was hypertension (40.0%) followed by diabetes mellitus, smoking, dyslipidaemia and family H/O CAD were significantly associated with the development of CAD in the study subjects. Conclusion: Treadmill exercise stress echocardiography demonstrates high significance for diagnosis of CAD.

University Heart Journal Vol. 17, No. 2, Jul 2021; 114-117
JARINGAN PERDAGANGAN BERAS DAN DINAMIKA PELABUHAN EKSPOR DI SULAWESI SELATAN PADA 1930-AN
Authors: Musyaqqat Syafaat Rahman
Published: June 2021

As the National rice barn, the Southern Sulawesi is often associated with the green revolution of the New Order Regime, especially since Indonesia succeeded the rice self-sufficency in 1984. Furthermore, Southern Sulawesi has an important role as rice supplier in Indonesia which was proven in 1930s. The state control is one of main factors supporting Southern Sulawesi’s success, along with another factor particularly environmental conditions and irrigation development. This article discusses the rice trade network and its relationship to the dynamics of export ports in Southern Sulawesi in the 1930s. By applying the historical method, this study employed primary sources, such as archives, journals, newspapers, and magazines. The findings show that the rice trade during the 1930s experienced a significant development as the state involved in the trade in 1933. The increase was seen in the trading system and the amount of exported rice. The increase which was seen in the trading system and the amount of exported rice indicates the significance of Southern Sulawesi as one of the rice barns in the Dutch East Indies. By describing the production areas, involved actors, export ports, and trade networks, this study shows the relationship between intra- and inter-regional trade.
Analysis of FXS (Foreign Exchange Subscriber) Port on IPPBX (Internet Protocol Private Branch Exchange)
Authors: Anggraini Dyah
Published: June 2021

PBX is a telephone communication connection device that is commonly used in buildings that require a telephone connection. However, some PBX products cannot be directly connected to analog telephones, so they require a module called an S2 module. S2 module can converts the port on the PBX to an FXS port that can be connected to an analog phone. Apart from PBX, there is ITG which can be used as telephone line communication. However, ITG already has an FXS port so it does not require additional modules. In Indonesia, there are standard provisions for the use of analog telephone communication devices which have been regulated in SNI for analog telephones. This research examines analog telephone communication devices according to SNI in Indonesia. The results of this test show the TA400 and MyPBX Standard at the impedance value when the on-hook state gets an average value of 64 K?, when the off-hook condition averages a value of 343 ?, the AC voltage test when the call comes on average gets a value of 343 ?. a value of 60 VAC, which means that it meets the SNI standard.
Designing an Employee Attendance Information System Using Identity Cards (KTP) (Case Study of the Ngajum District Office)
Authors: Sasono Rivano Dwi
Published: June 2021

Employee attendance is one of the most important elements in office activities. Attendance is a data collection activity to determine the number of employee attendance. The employee attendance system at the ngajum sub-district office uses fingerprint technology (Fingerprint). This system is indeed very easy and efficient, but in the sub-district office there are several employees who have difficulty carrying out the fingerprint attendance process because the fingerprints are peeled off or have certain diseases make fingerprints smooth. So that the fingerprint attendance (Fingerprint) at the sub-district office is not used and returns to the manual system. The purpose of this research is to design an employee attendance information system to enter and leave by utilizing the National Identity Card or KTP. For checking IDKTP uses the NFC Reader PN532 which is connected to Arduino Uno as a microcontroller, Raspberry pi as a web server, webcam, LCD display, and buzzer as a sign of success in making attendance. Based on the test results it can be concluded, the NFC reader used can read ID KTP in position vertical and horizontal with a distance of less than 16 mm. When there is a mica barrier and a glass barrier the maximum reading distance is less than 14 mm while the plate and aluminum foil barrier cannot be read. The existence of a barrier makes the distance to read the KTP will be reduced.
Design To Build The Stacked Turnstile Antenna 2.4 GHz for Wireless Local Area Network (WLAN)
Authors: Sitoresmi Erwan Dian , Waluyo Waluyo , Koesmarijanto Koesmarijanto
Published: June 2021

The purpose of this research is to design an antenna that will be used as a transmitting antenna that can level up the receiver. The designed antenna is a stacked turnstile antenna that has again of 3dB from previous studies. At the turnstile antenna using a power divider to raise the antenna gain of 1.5dB. Power divider is used Wilkins on power divider with a vertical stack. The stack distance used is0.6?. From the results of the implementation of the AntennaLaboratory of the Polytechnic of Malang, a stacked turnstile antenna produces vertical polarization and omnidirectional radiation patterns. Value of the measured return loss is-13.8dBat a frequency of 2,384MHz. Additionally stacked turnstile antenna has a value of 4.83dBi gain. VSWR values were measured at a frequency of 2,384GHz is 1,091 and has 425MHz bandwidths frequencies ranging from 2275 to 2700MHz. Level of signal reception at the access point-Link TL Type WA 5110G higher than 4dbm antenna access point, while stacked turnstile antennas transmitting antenna at a maximum distance of 100m to get the signal reception is better than 84dB antenna access point signal reception-89dB.
Coordinating Information System for Tuna Fishing Area Prediction for Fishermen
Authors: Sugiari Sugiari
Published: June 2021

One of the products of Indonesia's fishery is Tuna. To overcome the increasing demand of the world market, the Ministry of Marine Affairs and Fisheries provides routine information on map information on potential zones of fish, especially Tuna. However, for some fishermen it is relatively difficult to access the map because it requires the internet, so it becomes an obstacle in disseminating information on this fish potential zone map. From the above problems, such as the lack of knowledge of fishermen regarding the condition of the location of tuna points, while the current information is relatively difficult to obtain for some fishermen, so it is necessary to develop a "Coordinating Information System for Tuna Fish Estimates for Fishermen". With this system, it can make it easier for fishermen to subscribe to tuna fish coordinate update information either through the website or via SMS. The method used to determine the coordinates of the fish on the PDPI map is to use image processing with the medium scaling method SMS was chosen because it is one of the media for transferring information that is widely used among middle to lower income fishermen. From the results of testing and analysis of software. digital coordinates can run with an average reading duration of 31.651 seconds. The map error tolerance for longitude is 1099,591 meters and for latitude is 1401,939 meters.
Analysis of PPTP and L2TP/ IPSEC VPN Network Security Performance for FTP Server at State Polytechnic of Malang
Authors: Mahardiyanto Muliatama Putra
Published: June 2021

Data exchange communication has developed that leads to centralized communication, and to realize this communication, a type of data communication is needed whose data is stored on a server and can be accessed by clients, such as at the Malang State Polytechnic. As an institution engaged in the world of education, the development of data communication is centralized by utilizing the established intranet network. The use of an intranet network allows for data communication that is vulnerable to eavesdropping. To overcome this, use a VPN network. PPTP VPN and L2TP/IPsec VPN have different performances, especially in the level of security provided. In this study, the performance analysis of the PPTP VPN and L2TP/IPsec VPN networks was carried out which was implemented on an FTP Server on a Raspberry Pi server and a Mikrotik router for the VPN configuration. In this study, we designed PPTP VPN and L2TP/IPsec VPN by configuring the Mikrotik RB9412nD-TC router and configuring FTP Server using the proftpd application on the Raspberry Pi server. For security analysis using hacking method to get VPN Server login data and sniffing method to get FTP Server login data, FTP data. For performance analysis using parameters delay, throughput, and packet loss.
Designing of Data Communication System for Night Bus Services Using Web-Based Barcodes and GPS Shields and Raspberry Pi
Authors: Wijaya Adi Putra
Published: June 2021

The bus is one of the mass transportation used by many people. With the rapid development of technology to find out the position of the bus, you can use a GPS tracker which has the ability to transmit real-time data. Use the barcode added to the bus ticket to find out the status of passengers getting on or off. Raspberry Pi functions to control Modem, Barcode Scanner, GPS Tracker. Raspberry Pi will process the GPS Tracker data on the bus to find out the coordinates of the bus. Barcode and GPS Tracker information will be retrieved from the webserver. Users will get bus information via a web smartphone by sending the bus police ID number. The application features contain agent information, bus destination code information, bus departure hours, bus tracking, and passenger status. Based on the test results, the tolerance value is 0.1" for latitude, the distance meter longitude value is 0.2". GPS Tracker will send more accurate data when in the city. In the Malang-Jakarta GPS Tracker test, there were not too many tree obstacles. Barcodes that have been scanned using a barcode reader will turn the seats on the display green.
Information System of Nearest Schools Locations with School Social Networks and students' Parents based on Website (Case Study of Early Childhood Education and Elementary School in Malang City)
Authors: Nurmalasarri Aisy
Published: June 2021

This information system aims to find the closest distance from the parents' house to the school in Malang by looking at the location map that has been provided on the web. Making this web-based information system using the programming language PHP and MySQL and AMPPS to create the required database on the web. Social networks are created in the form of profile processing, photo galleries, and message processing. The search for location points is determined by the admin and the user's coordinates can be known automatically and the results obtained from the calculation of the distance on the web or manually are obtained from the SDN Jatimulyo 4 with a distance of 92 meters on the web and 0.1 km on the calculation manually using a spido meter, the closest PAUD to the user's coordinate point is TK Tadika Puri with a distance of 1.1 km on the web and 1.2 in manual calculations using a spido meter. This shows that the closest distance using google maps and manual calculations using a spido meter to search for the nearest location gets almost the same results, so the analysis of the results can be said to be a good category.
Simulation of Galian C Mining Communication Management between the Company and the Local Government
Authors: Hakim Basuki Rahmat
Published: June 2021

The purpose of making this system is to monitor the purchase of excavated sand C to reduce fraudulent payment of levies by mine owners and make it easier for DISPENDA to control mining vehicles. This system uses 2 pieces of RFID which are used to identify vehicle numbers that leave and enter the mine. At the entrance and exit of the mine there is a load cell that is used forweighing the weight of sand which is used as the basis for the levy value and the price of sand. From the results of the load cell test, it shows that the calibration results were carried out well. This is proven by the measurement accuracy of the load cell. Based on data from test resultsQOS where the average value of transmission delay is 113.5 ms, throughput is at 0.077 mbit / sec - 0.138 mbit / sec and packet loss is 0.0%. In accordance with the TIPHON standard, this situation belongs to a very good range.
BTS (Base Transceiver Station) Route and Site Search Application Using Speech To Text on Android Devices
Authors: Fadhilah Tiara Anggun Nur
Published: June 2021

in order to implement the technology development of a BTS (Base Transceiver Station) device from a project a vendor and operator. Take advantage of the services provided by the Android smartphone, namely Google maps along with voice, namely speech to text, can further help the performance of a survey team at the sub party contractor (subcon) / third part. The results of application testing and analysis show that speech to text testing for noise is: average for distances of 10cm and 35cm with a noise level of 63 dB as much as 79% success, on average for distances of 10cm and 35cm with a noise level of 70 dB as much as 75% success, average for the distance 10cm and 35cm with a noise level of 75 dB for 72% success. Testing time when opening Maps from the text to maps results, it is found that the speed of male voice is faster, namely 1 minute 51 seconds and 1 minutes 68 seconds than women. Finally, testing the comparison of the distance between the application and the calculation through the Euclidean Distence formula, the average distance obtained in the application is 3.65345287 km and the calculation result with the Euclidean Distance formula is 3,66535889 km.
Design of a Monitoring System for Level and Speed of Water Flow and River Condition Recorder Based on Android
Authors: Al Anas Abd. Wahid
Published: June 2021

Now a days, the condition of the river has been contaminated by householdwaste especially in the urban areas, the waste comes from people who are not responsible for the trash,so it potentially causes floods. Therefore, this research aims to design a system to monitor water level height and water speed as well as river condition recorder based on android. The use of ultrasonic sensor as an indicator to find out high levels of surface water, the optocoupler sensor as an indicator to know the speed of the water flow and IP cameras as a tool of monitoring the condition of the river are actual and direct. Research on the design of the ultrasonic sensor and optocoupler sensor resulted in average percentage error of measurement of 0.54% and 9.35%. IP camera that was designed as a visualization tool monitoring the condition of the river was able to produce on average the smallest delay 0ms. The notification system was implemented on the device users generating the biggest delay on average 22,9s and an average delay of the smallest 9,6s. QoS analysis on android gained the biggest delay of 1.64ms, the largest throughput of 81.01 Kb/s and packet loss of 0%. While QoS analysis on the website obtained the biggest delay of 58ms, the largest throughput of 19.3 KB/s and packet loss of 0%.
Design of Communication Network Performance Applications Fiber Optic (FO) as One of Node B (NB) Transmission Media in Malang Area based on Android
Authors: Hakim Ahmad Maulana
Published: June 2021

Fiber optic is chosen to be the backbone channel for telecommunication purposes, in this case the connection between nodes b. Therefore, to determine the performance of a fiber optic network, a fiber optic communication network performance application is required. The performance discussed in this study is total attenuation, Optical Signal to Noise Ratio (OSNR) and Bit Error Rate (BER). The method used to obtain the attenuation value along the length of the cable and the total attenuation is by measuring the fiber optic network with an Optical Time Domain Reflectometer (OTDR). After taking measurements, the data is processed to produce output in the form of network performance, namely the total attenuation value, OSNR and BER. The results of the accuracy of the two comparisons are indicated by the percentage error rate. Based on the overall data tested, a value of 5.53% was obtained for comparison between the theoretical results and the value of the measurement results and obtained a value of 5.10% for the comparison between the measurement value and the application calculation value. Then the relationship between total attenuation with OSNR and the relationship between OSNR and BER is an inverse relationship.
Design of Solar Panel Light Monitoring and Controllers Using a Web-Based Arduino
Authors: Gustiana Dinari
Published: June 2021

In the Modern Era, a source of electrical energy is very necessary, given the large number of electronic equipment that really requires a source of electrical energy. Solarcell is a device or component that can convert light energy into electrical energy. However, the energy used in this solar panel needs to be considered the efficiency of its use. Therefore it is necessary to monitor currents and voltages and loads in real time to determine the energy needs of solar panels for lamps. Monitoring of voltage, load and current on this solar panel is based on a microcontroller. The voltage generated by the solar panel and the battery voltage is measured using a sensor. It takes a Web and a modem device to send solar panel measurement data from a distance, with remote monitoring makes it easier to find out what the voltage and load is without having to be in place of the solar panel. Web as a control for lights, blackouts, dim and bright lights, on the web can monitor voltage and current values. The results of the microcontroller ADC are able to send data to the web. The data stored in the ms.excel file contains the voltage from the solar cell, the current at the load and the time when storing and charging the battery. The lights can only last 5 hours when all loads are active (ON), while charging (charging) for 13 hours when the battery is empty.
Measurement of Quality of Service (QoS) in File Sharing Applications with the Android-Based Client Server Method
Authors: Priadi Doni
Published: June 2021

In this research, an application is made that can make it easier to transfer files or data by utilizing a wifi connection on a network and then transferring files via a web browser using Hypertext Transfer Protocol (HTTP) server technology which will be installed on an Android-based smartphone. After that, it is necessary to measure network performance to determine the quality of the network in accessing the application. The measured performance is Quality of Service (QoS), which is a parameter that shows the quality of data packets on the network. Based on the results of measurements carried out by connecting the server to the AH building network and the client accessing from the AI ??building network at the State Polytechnic of Malang, when compared to the ITU-T standard, the application delay is in the very good category, jitter is in the bad category, the throughput value depends on the size. data sent. For packet loss, it is in the very good category. Meanwhile, based on measurements made using the Apache benchmark software, out of the 1000 requests that were tested, none of them failed or failed.
Analysis of Broadband City Service Performance Data Using the 500 x 500 Meter Grid Method
Authors: Khaerunisa Najwa
Published: June 2021

The stability of the services used by the users requires operators to provide good network quality to meet their needs. Broadband city performance conditions will affect the service, especially in data services used by users. Sometimes when a user uses a data service, there are disturbances that cause communication to be obstructed between users. The research objective is to determine the condition of the city broadband performance and the causes of the speed test measurement results are on indicators 1 and 2. Determination of performance using several parameters related to the measurement of service performance data on the 500x500 meter grid. The implementation of the 500x500 meter grid method is done by mapping the points of interest and the results of measuring service performance data to the 500x500 meter grid. The results of the measurement results of the RSRP and SINR drive test parameters have a percentage of 100% and 98.2%, speed test 96.19%, utility 92.6%. The measurement results at certain hours, drive test parameters RSRP and SINR have a percentage of 100% and 100%, speed test 100%. The measurement results of 10 grids with 4 different points in one grid, drive test parameters RSRP and SINR have a percentage of 100% and 100%, and 100% speed test. Locations that require network optimization are locations where the total speed test results are on indicators 1 and 2.
Network Security System Implementation Using Raspberry Pi-Based Random Port Knocking Sent Via Telegram
Authors: Jeinever Iga Revva Princiss
Published: June 2021

Computer networks are basically not safe to access freely. Security gaps in the network can be seen by irresponsible people with various techniques. Opening a port for access carries a high risk of being attacked by an attacker. In this connection, network administrators are required to work more to be able to secure the computer network they manage. One form of network security that is often used by network administrators in server management is through remote login such as ports on telnet, SSH, etc. A port that is always open is a network security hole that can be used by people who are not responsible for logging into the server. Focusing on these problems, in this study, Random Port Knocking is the right way and can be used to increase network security. With Random Port Knocking, the port will be opened as needed, the port will automatically change when it fails to log in more than three times and IP will automatically be blocked and access will not continue so that attacks on the network can be avoided and network security stability can be further improved. The final result of this research shows that the method applied in this research makes server safe. Because port randomization and IP block make irresponsible parties try harder to penetrate firewall walls.
Design of an Object Height Detection Model under the Line of Sight (LoS) Communication Line using a Laser Distance Meter
Authors: Wisha Narindra heronita
Published: June 2021

The world of telecommunications is growing rapidly so that cellular operator providers are trying to upgrade their networks to meet the needs of their customers with good quality. One effort that can be done is to build a new Base Transceiver Station (BTS). The aim of this research is to create a detection tool capable of detecting objects at a certain height below the line of sight (LoS) line of communication using the laser technology that has been developed. Topographic surveys and building planning are very important and required before building a BTS with an LOS. In this study, the Laser distance meter (rangefinder model) can measure the farthest distance up to 135 meters due to the limited area used. Experiments were applied to several objects to test the ability of the laser used and obtained the maximum distance of the TS832 transmission media reaching 70.7 meters.
Design and Implementation of Chebyshev Band Pass Filter with M-Derived Section in Frequency Band 88 - 108 MHz
Authors: Novarianti Dini
Published: June 2021

FM radio broadcasting is a wireless communication system. Transmission in the frequency 88-108 MHz requires a bandpass filter to avoid interference with frequencies adjacent to the radio transmitter. The type of filter that has a fairly good performance is the Chebyshev filter with a fairly high level of steepness. However, to get a high level of steepness, a fairly large element value is required. So, in this study adding the m-derived series to give a steeper filter response without adding more element values.The purpose of this thesis is to determine the effect of adding an m-derived section to the chebyshev bandpass filter. The parameters tested are passband bandwidth, stopband bandwidth, shape factor, insertion loss, roll off, and power attenuation when used on the transmitter.Based on the measurements that have been made, it can be seen that the bandpass filter without m-derived has a maximum insertion loss value of 7 dB and a minimum insertion loss of 9 dB, while the bandpass filter with m-derived is 11 dB and 13. In the bandpass filter without m-derived and m-derived have a passband bandwidth of 27 MHz and 29 MHz and a stopband bandwidth of 70 MHz and 50 MHz. So that the bandpass filter without derived and m-derived has a shape factor value of 2.59 and 1.72. In the implementation using the transmitter, the bandpass filter without m-derived has a power attenuation of 2.53 dB while the m-derived bandpass filter has an attenuation of 1.5 dB.
Design of Filtering Systems for Monitoring the Quality of Household Drinking Water
Authors: Arindita Usita Putri Dwi
Published: June 2021

Processing water products sources into ready-to-drink water have been widely circulated in community, one of it's a household drinking water filter with 4 filter stages. Drinking water itself is indispensable for human body. It's because most of the human body is made up of water. To meet the water needs in human body, drinking water is required. Drinking water that consumed by community must meet drinking water standards that have been determined by Minister of Health Decree No. 492/2010, which must meet physical, chemical, biological and radioactive requirements.This research aimed at monitoring several drinking water quality parameters in form of Ph (6.5 - 8.5), Turbidity (<5 NTU) and temperature (22 ? - 27 ?) by using pH sensor, turbidity sensor and temperature sensor, and ON/OFF scheduling of ultraviolet light as an inhibitor of bacterial growth which then monitoring results will be sent via nodeMCU ESP8266 and displayed on WEB. The results of the Ph sensor readings show a reading accuracy of up to 97.28%, on the temperature sensor the reading accuracy reaches 98.7%, while the turbidity sensor has an accuracy level of up to 98.875%, the ON/OFF of UV light goes according to schedule. The application software used able to read and store data in real time from water quality sensor so users can monitor quality of drinking water. Water from filtration of water filter can be categorized as suitable for drinking in accordance with drinking water standard in the Decree of Minister of Health No. 492 in 2010.
Detection and Monitoring System for Custody Room Using SW-420 Vibration Sensor with LAN Communication
Authors: Permana Handy Trias
Published: June 2021

Securing detention rooms in Indonesia, using manual methods from humans to secure them. Officers check the detention room periodically. Several cases that occurred, such as the escape of prisoners from the Cawang Police and the Lhoksukhon Detention Center, the detainees broke into the bathroom wall using metal bars to be used as a media for breaking the walls. To prevent recurrence of cases, an early detection design is needed when there is a detention room indicated that it will be damaged by installing a vibration detection device on the wall. In this study, the SW-420 vibration sensor is used as a vibration detector when there is a wall to be broken into and several cameras installed in the corridor to visually monitor the occupants of the detention room. Vibration data will be sent to the detention room website via Arduino Uno, while the IpCamera will be connected to the router to display the video capture results on the website. For example, the bathroom plan for the detention room at the Gondanglegi Police Station that has been made, the sensor node is placed at the center point of the bathroom wall at a position of 60 cm which divides it into 2 parts. Arduino Uno will dynamically have IP when connected to the router using a Lan cable. Based on the experiment in the previous chapter, how to adjust the sensor sensitivity can be done by turning the sensitivity adjustment and adjusting the threshold on the website code.
Rectifier Design in RF Energy Harvesting System with Television Antenna at UHF Frequency
Authors: Rajab Muhammad Novian Rahmatur
Published: June 2021

Nowadays, the development of technology is increasing rapidly, one of which is the development of telecommunication technology. Telecomunication provides communication services by using radio waves as information carriers, as a result of the large number of electromagnetic waves in the natural surroundings. From this, various studies have now been developed in order to be able to utilize the energy contained in electromagnetic waves that are around as an alternative energy source, also called Energy Harvesting. The purpose of making this thesisis to make a rectifier and integrated with a television antenna to convert the RF signal at the UHF frequency (470MHz-807 MHz) into DC voltage energy as an Energy Harvesting system. In this final project, a 2.4 and 6-stage voltage douber rectifier was designed using the HSMS 2820 diode and integrated with television antenna. The results of the rectifier circuit made are circuit simulation. The rectifier is able to convert the AC input to DC and amplify the output voltage to achieve multiple stages of the circuit used. In the 6-stage rectifier circuit fabrication test, the largest output produced reached 1.3 V with an input of 0.398 V at a frequency of 470 MHz while the output was the smallest is 3 mV with an input of 0.022 V at a frequency of 637 MHz, and in testing using a TV antenna as an RF signal catcher from the transmitter, the largest voltage obtained reaches 1,019 V in a 6-stage circuit, the output voltage is DC voltage.
Targeting the Nerve Growth Factor Signaling Impairs the Proliferative and Migratory Phenotype of Triple-Negative Breast Cancer Cells
Authors: Di Donato Marzia , Galasso Giovanni , Giovannelli Pia , Sinisi Antonio A. , Migliaccio Antimo , Castoria Gabriella
Published: June 2021

Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored approach in the clinical management of patients. Nerve growth factor, initially identified as a key factor for neuronal survival and differentiation, turned out to be a multifaceted molecule with pleiotropic effects in quite divergent cell types, including cancer cells. Many solid tumors exhibit derangements of the nerve growth factor and its receptors, including the tropomyosin receptor kinase A. This receptor is expressed in triple-negative breast cancer, although its role in the pathogenesis and aggressiveness of this disease is still under investigation. We now report that triple-negative breast cancer-derived MDA-MB-231 and MDA-MB-453 cells express appreciable levels of tropomyosin receptor kinase A and release a biologically active nerve growth factor. Activation of tropomyosin receptor kinase by nerve growth factor treatment positively affects the migration, invasion, and proliferation of triple-negative breast cancer cells. An increase in the size of triple-negative breast cancer cell spheroids is also detected. This latter effect might occur through the nerve growth factor-induced release of matrix metalloproteinase 9, which contributes to the reorganization of the extracellular matrix and cell invasiveness. The tropomyosin receptor kinase A inhibitor GW441756 reverses all these responses. Co-immunoprecipitation experiments in both cell lines show that nerve growth factor triggers the assembly of the TrkA/β1-integrin/FAK/Src complex, thereby activating several downstream effectors. GW441756 prevents the complex assembly induced by nerve growth factor as well as the activation of its dependent signaling. Pharmacological inhibition of the tyrosine kinases Src and FAK (focal adhesion kinase), together with the silencing of β1-integrin, shows that the tyrosine kinases impinge on both proliferation and motility, while β1-integrin is needed for motility induced by nerve growth factor in triple-negative breast cancer cells. The present data support the key role of the nerve growth factor/tropomyosin receptor kinase A pathway in triple-negative breast cancer and offer new hints in the diagnostic and therapeutic management of patients.
Differential Regenerative Capacity of the Optic Tectum of Adult Medaka and Zebrafish
Authors: Shimizu Yuki , Kawasaki Takashi
Published: June 2021

Zebrafish have superior regenerative capacity in the central nervous system (CNS) compared to mammals. In contrast, medaka were shown to have low regenerative capacity in the adult heart and larval retina, despite the well-documented high tissue regenerative ability of teleosts. Nevertheless, medaka and zebrafish share similar brain structures and biological features to those of mammals. Hence, this study aimed to compare the neural stem cell (NSC) responses and regenerative capacity in the optic tectum of adult medaka and zebrafish after stab wound injury. Limited neuronal differentiation was observed in the injured medaka, though the proliferation of radial glia (RG) was induced in response to tectum injury. Moreover, the expression of the pro-regenerative transcriptional factors ascl1a and oct4 was not enhanced in the injured medaka, unlike in zebrafish, whereas expression of sox2 and stat3 was upregulated in both fish models. Of note, glial scar-like structures composed of GFAP+ radial fibers were observed in the injured area of medaka at 14 days post injury (dpi). Altogether, these findings suggest that the adult medaka brain has low regenerative capacity with limited neuronal generation and scar formation. Hence, medaka represent an attractive model for investigating and evaluating critical factors for brain regeneration.
Oncogenic Chromatin Modifier KAT2A Activates MCT1 to Drive the Glycolytic Process and Tumor Progression in Renal Cell Carcinoma
Authors: Guo Yuanyuan , Liu Beibei , Liu Yihan , Sun Wei , Gao Wuyue , Mao Shilong , Chen Li
Published: June 2021

Objectives

This study aims to investigate the underlying mechanisms of KAT2A/MCT1 axis in renal cell carcinoma (RCC), providing potential therapeutic targets.

Methods

We obtained the expression data of KAT2A and MCT1 from The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) and International Cancer Genome Consortium (ICGC) databases. Differential analysis was conducted via the limma package. The CCK8 assay, soft agar assay, clone formation assay, and patients-derived organoid models were used to detect cell growth. The transwell and wound-healing assays were utilized to detect cell migration. The in vitro and in vivo assays were further conducted to assess the oncogenic roles of KAT2A. The transcriptome sequencing and chromatin immunoprecipitation (ChIP) sequencing were conducted to screen KAT2A downstream targets. The dose-effect curves were used to detect the 50% inhibiting concentration (IC50) of AZD3965. Data analysis was performed in the Graphpad Prism (Version 8.3.0) and R software (Version 3.6.1).

Results

Our study found that KAT2A was highly expressed in RCC versus normal samples. Prognostic analysis indicated that a high KAT2A was an independent biomarker and associated with poor survival outcomes. KAT2A could promote RCC proliferation and distal metastasis in vitro and in vivo. Transcriptome analysis and ChIP-seq were combined to find that KAT2A mainly regulated the glycolytic process. Validation and rescue assays revealed that MCT1 was the downstream target of KAT2A, and KAT2A depended on MCT1 to promote RCC malignant phenotypes. Lastly, MCT1 inhibitor (AZD3965) was effective to treat KAT2A-induced RCC progression.

Conclusion

Our study indicated that KAT2A was an oncogenic chromatin modifier that promotes RCC progression by inducing MCT1 expression. We proposed that MCT1 inhibitor (AZD3965) was useful for suppressing RCC.