bluuebunny/crossref_metadata_2025 huggingface dataset:
Identificación de adulteraciones en café tostado mediante cromatografía de gases acoplada a espectrometría de masas
Authors: Campoverde León Joseph David , Santín Kaila , Figueroa Jorge G.
Published: January 2022

En el mundo, el café es el segundo producto más comercializado después del petróleo. Sin embargo, debido a su elevado precio, suele ser adulterado con materiales de menor costo. El objetivo de la presente investigación fue desarrollar un método basado en la combinación de las técnicas de microextracción de fase sólida (SPME) con la cromatografía de gases acoplado a espectrometría de masas (GC-MS) y el análisis de componentes principales (PCA), para detectar la presencia de haba y/o cebada en café tostado. Además, se optimizó la SPME de compuestos volátiles del café, mediante la metodología de superficie de respuesta. Respecto al método de extracción, se encontró que las condiciones óptimas fueron 16 y 35 min, para el tiempo de equilibrio y extracción, respectivamente. Por otra parte, se identificaron 44, 36 y 24 compuestos, en café, cebada y haba, respectivamente. De acuerdo con nuestro conocimiento, es el primer estudio respecto a la identificación de compuestos volátiles en haba tostada. Finalmente, el método desarrollado permitió detectar la probable presencia de haba en cuatro muestras comerciales de café. Además, se descartó la presencia de cebada en estas muestras.
Patient Perceptions of Dermatologic Photography: Scoping Review
Authors: Kim William , Sivesind Torunn
Published: January 2022

Background

Medical photography is used extensively in dermatology to record disease progression, measure treatment response, and help teach patients about skin disease; such photos are also commonly utilized in teledermatology, medical education, research, and medical reference websites. Understanding patient perceptions of medical photographs obtained during dermatologic care in the clinic or hospital setting is critical to enable the delivery of high-quality, patient-centered medical care.

Objective

The aims of this study were to elucidate patient perceptions of skin photos in dermatology and to explore possible next steps in improving the patient experience with medical photography in the hospital or clinic setting.

Methods

A scoping review of the literature was performed using the PubMed database, with clinic- or hospital-based full-text publications in English spanning the last 10 years considered for inclusion.

Results

The majority of included studies (10/11, 91%) found positive patient attitudes toward medical photographs. The majority of patients (1197/1511, 79.2%) felt that medical photographs could improve medical care in the clinic setting. Written consent detailing all photo uses, including secondary uses (such as research or teaching), was preferred, apart from in 1 study. Patients preferred or found it acceptable for the photographer of their medical photos to be a physician (1301/1444, 90.1%). Clinic-owned cameras with departmental record storage were the preferred modality. Latinx and African American patients expressed less trust in the utility of medical photographs to improve care, compared with Asian and White patients. The minimal number of available publications on this topic and the inclusion of articles older than 5 years are limitations, since patient perceptions of medical photography may have rapidly changed during this time span, particularly in light of the COVID-19 pandemic and the subsequent increase in teledermatology visits.

Conclusions

Patients reported positive perceptions of dermatologic photography for improving their medical care. Ethnic disparities in patient perceptions require further exploration to better elucidate nuances and develop interventions to improve the experience of marginalized patients. Building patient trust in nonphysician photographers may enhance clinic efficiency. Although clinic-owned cameras are well-accepted by patients, improved patient education surrounding the safety of electronic medical record phone applications is needed.
Associations Between Prenatal Exposure to Serotonergic Medications and Biobehavioral Stress Regulation: Protocol for a Systematic Review and Meta-analysis
Authors: Zusman Enav Z , Lavu Alekhya , Pawliuk Colleen , Pawluski Jodi , Hutchison Sarah M , Platt Robert W , Oberlander Tim F
Published: January 2022

Background

Up to 20% of mothers experience antenatal depression and approximately 30% of these women are treated with serotonergic psychotropic pharmacological therapy during pregnancy. Serotonergic antidepressants readily cross the placenta and the fetal blood-brain barrier, altering central synaptic serotonin signaling and potentially altering serotonin levels in the developing fetal brain.

Objective

The aim of this study is to assess the impact of prenatal exposure to serotonergic antidepressants, accounting for maternal mood disturbances, on markers of stress regulation during childhood.

Methods

We will follow PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and will search MEDLINE, Embase, CINAHL, PsycINFO, and ClinicalTrials.gov for full-length studies that assessed physiological (eg, cortisol level, heart rate variability, salivary amylase, pupillary size, C-reactive protein) indices of stress regulation in children of pregnant people who were treated with a serotonergic antidepressant at any point during pregnancy. We will assess the quality of observational studies using the Newcastle-Ottawa Scale and the quality of experimental studies using the Cochrane risk-of-bias tool. When possible, we will conduct a random-effects meta-analysis. If meta-analysis is not possible, we will conduct a narrative review. If a sufficient number of studies are found, we will perform subgroup analysis and assess outcomes measured by drug class, dose, trimester of exposure, and child’s age and gender.

Results

We registered our review protocol with PROSPERO (International Prospective Register of Systematic Reviews; CRD42021275750), completed the literature search, and initiated title and abstract review in August 2021. We expect to finalize this review by April 2022.

Conclusions

Findings should identify the impact of prenatal antidepressant effects on stress regulation and distinguish it from the impact of prenatal exposure to maternal mood disturbances. This review should inform decisions about serotonergic antidepressant use during pregnancy.

Trial Registration

PROSPERO CRD42021275750; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=275750

International Registered Report Identifier (IRRID)

PRR1-10.2196/33363
Growth and Disparities in Mental Health, Telemedicine, and Telemedicine Mental Health Usage between 2013 and 2018 among Disabled Medicaid Clients in Urban, Suburban, and Rural Texas Counties: A Cohort Study (Preprint)
Authors: Ukert Ben , Kum Hye-Chung , Lawley Mark
Published: January 2022

BACKGROUND

Healthcare services delivered through remote technology, known as telemedicine or telehealth, have been growing across the country and can improve access to care for needy populations. However, uptake and the growth in telemedicine use has not been well documented.

OBJECTIVE

To examine the disparities in the growth in telemedicine use and telemedicine use for mental health care in rural and urban Texas counties.

METHODS

Texas Medicaid claims data were analyzed from September 1, 2012 to August 31, 2018 for Medicaid members enrolled due to a disability. We analyzed the growth in telemedicine care based on geography and mental health status.

RESULTS

Medicaid client panels grew at 132% for telemedicine providers, with urban clients growing the fastest (255%). Clients with a telemedicine visit for a mental health condition grew by 77%. Telemedicine clients with mental health diagnoses tended to have 2 to 3 more visits per year than non-telemedicine mental health clients.

CONCLUSIONS

Growth in telemedicine care was strong in urban and rural areas between 2013 and 2018. Those with a mental health condition who received telemedicine care had a higher number of total mental health visits compared to those without telemedicine care. These findings hold across all geographic groups and suggest that mental health telemedicine visits did not substitute for face-to-face mental health visits.
Smartphone applications for patients with low back pain: self-management, telerehabilitation, evaluation and data collection. A scoping review (Preprint)
Authors: Dobija Lech , Lechauve Jean-Baptiste , Mbony-Irankunda Didier , Plan-Paquet Anne , Dupeyron Arnaud , Coudeyre Emmanuel
Published: January 2022

BACKGROUND

Technological developments have accelerated notably in the field of telecommunications in the last few decades. Smartphone use has grown in providing healthcare for patients with low back pain (LBP), but the literature lacks an analysis of the use of smartphone apps.

OBJECTIVE

This scoping review aimed to identify current areas of smartphone app use for managing LBP. We also aimed to evaluate the current status of the effectiveness or scientific validity of such use and determine perspectives for their potential development.

METHODS

We searched PubMed, PEDro and Embase for articles published up to May 2021 that investigated smartphone use for LBP healthcare and their purpose.

RESULTS

We included 42 articles: randomised controlled trials (RCTs) (n=12), study protocols (n=6), reliability/validity studies (n=6), systematic reviews (n=7), cohort studies (n=4), qualitative studies (n=5), and case series (n=1). The purposes of the smartphone app were for 1) evaluation, 2) telerehabilitation, 3) self-management, and 4) data collection. Self-management was the most-studied use, showing promising results derived from moderate- to good-quality RCTs for patients with chronic LBP and patients after spinal surgery. Promising results exist regarding evaluation and data collection use and contradictory results regarding measurement use.

CONCLUSIONS

This scoping review revealed a growing scientific literature regarding the use of smartphone apps for LBP patients. The identified purposes point to current scientific status and perspectives for further studies including RCTs and systematic reviews targeting specific usage. Caution should be taken to monitor the impact of smartphone-related compulsive behavior.
Timeliness of single-patch 12-lead electrocardiography for patients with chest pain at the emergency department (Preprint)
Authors: Yoo Suyoung
Published: January 2022

BACKGROUND

In emergency departments, a 12-lead electrocardiography (ECG) is the basis for diagnosing and treating patients with chest pain. Many studies have shown that performing ECG at the right time can improve treatment outcomes. A wearable ECG with a timer can ensure its timely recording.

OBJECTIVE

Here we aimed to compare the time accuracy of single-patch 12-lead ECG with that of conventional ECG, hypothesizing that the former would show improved time accuracy.

METHODS

Among adult patients who visited the emergency room with chest pain but not in shock were randomized and divided into single-patch wireless 12-lead ECG(SP-ECG) group and conventional ECG (C-ECG) group. Of the 36 recruited patients, 33 were included in the final analysis. The primary outcome was the comparison of the time taken between the two groups for recording the ECG. The average age of participants in the two groups was 63.7 and 58.1 years, respectively

RESULTS

For the first follow-up ECG, the timeliness of SP-ECG group and C-ECG group was 87.5% and 47.0%, respectively (P < .74). At the second follow-up, it was 75.0% and 35.2%, respectively.

CONCLUSIONS

Continuous ECG minimizing interference with other examinations is possible and suitable for complex emergency department situations. However, the accuracy of single-patch ECG has not been verified. In addition, some minor issues with the device were identified. The application of SP-ECG is expected to improve overcrowding or human resource shortages in the emergency department, but further research is needed.
Частота серцевих скорочень та артеріальна гіпертензія: вплив на смертність та захворюваність
Authors: Sirenko U. M.
Published: January 2022

Артеріальна гіпертензія (АГ) — один із найсильніших факторів ризику атеросклерозу. Давно відомо, що АГ провокує атеросклеротичні зміни у стінках артерій та призводить до виникнення ускладнень. Через які патогенетичні механізми АГ може спричинити розвиток атеросклерозу? Найбільш очевидним є механічний вплив на артеріальну стінку. Як турбулентний кровотік, так і механічне пошкодження ендотелію відіграють певну роль у розвитку атеросклерозу. АГ провокує виникнення турбулентного току крові, а гемодинамічне навантаження впливає виключно на місця біфуркацій артеріального дерева. Турбулентний потік крові може викликати появу та прогресування атеросклеротичного ураження на внутрішній поверхні артерій.
Лечение пациентов с артериальной гипертензией в 2014 г.: возможности телмисартана
Authors: Bagriy A.E.
Published: January 2022

Лечение артериальной гипертензии (АГ) — одна из приоритетных задач медицины. АГ представляет собой важнейший из модифицируемых факторов сердечно-сосудистого риска (т.е. таких факторов, на которые врач и сам больной могут воздействовать). Убедительно продемонстрированы положительные эффекты адекватного и долгосрочного снижения артериального давления (АД): при его контроле в пределах так называемых целевых значений (см. ниже) происходит значительное уменьшение риска развития мозговых инсультов, инфарктов миокарда, снижения функции почек, периферических сосудистых осложнений.
Нейрогуморальний вплив артеріальної гіпертензії та хронічної хвороби нирок на гострий інфаркт міокарда: патогенетичні взаємодії ремоделювання серця з використанням антагоністів альдостерону
Authors: Tashchuk V.K. , Polianska O.S. , Hulaha O.I. , Hinhuliak O.M.
Published: January 2022

Перебіг гострого Q-інфаркту міокарда при наявній артеріальній гіпертензії супроводжується надмірною активацією ренін-ангіотензин-альдостеронової системи, втратою скорочувальної здатності гладком’язових клітин, розширенням передсердь, а зменшення рівня нейропептиду вазопресину при використанні антагоністів альдостерону забезпечує функціонуючий захист від розвитку серцевої недостатності. Еплеренон порівняно зі спіронолактоном сприяє більш вираженому зниженню концентрації альдостерону, особливо у хворих із хронічною хворобою нирок ІІ стадії. Рівні передсердного натрійуретичного пептиду, ангіотензинперетворювального ферменту та фактора Віллебранда у таких хворих при застосуванні спіронолактону мали статистично вірогідну тенденцію до зростання, а при використанні еплеренону спостерігалося вірогідне зниження їх концентрації. Параметри нейрогуморальних показників служать не тільки діагностичними маркерами перебігу захворювання, окремі з них є незалежними предикторами розвитку та прогресування кардіоваскулярних катастроф.
Динаміка клініко-біохімічних та імунологічних параметрів у хворих на гострий гепатит В із супутнім хронічним вживанням алкоголю в гепатотоксичних дозах
Authors: Rуabokon’ O.V. , Furyk O.O.
Published: January 2022

У роботі показано, що у хворих на гострий гепатит В із супутнім хронічним вживанням алкоголю в гепатотоксичних дозах розпал захворювання характеризується нижчим умістом інтерлейкіну-2 та вищим рівнем інтерлейкіну-8 у сироватці крові порівняно з пацієнтами без цього супутнього фактора. У період реконвалесценції у цих хворих зберігається дисбаланс цитокінового статусу за рахунок нижчого вмісту інтерлейкіну-2 та вищого рівня інтерлейкіну-6 й інтерлейкіну-8 у сироватці крові та супроводжується вищою активністю аланінамінотрансферази, частішою циркуляцією в крові HBsAg та меншою частотою сероконверсії з появою anti-HBe
Малярія (клінічна лекція)
Authors: Yershova I.B. , Osypova T.F. , Mochalova G.O. , Kalapala B.
Published: January 2022

У лекційному матеріалі наведено сучасні дані про поширеність, захворюваність та смертність від малярії в світі та Україні, етіопатогенетичні, клінічні особливості різних форм малярії, сучасні методи діагностики, лікування та профілактики малярії, а також тактику епідеміологічного нагляду у разі виникнення малярії в Україні. Лекція розрахована на лікарів-інфекціоністів, сімейних лікарів, педіатрів. Матеріали лекції можуть бути корисними для студентів 4–6-х курсів вищих медичних навчальних закладів.
Клінічні та окремі імунологічні фактори ризику генералізованих інфекційно-запальних процесів у новонароджених
Authors: Koloskova O.K. , Bezrukov L.O. , Bilous T.M. , Honcharuk R.I.
Published: January 2022

У роботі на підставі комплексного обстеження 100 новонароджених дітей показані клінічні та окремі імунологічні особливості, що асоціюються з розвитком раннього неонатального сепсису, найбільш вагомими з них є недоношеність, маргінальні показники маси тіла при народженні й проведення інвазивних маніпуляцій та обстежень. Показано, що вміст С-реактивного білка в сироватці крові > 60,0 мг/л вірогідно асоціюється з ризиком сепсису в новонародженого віком до 48 годин зі співвідношенням шансів 1,9.
Эхинококкоз в Оренбургской области: эпидемиологические, иммунологические и таксономические аспекты
Authors: Korneyev A.G. , Trishin M.V. , Solovykh V.V. , Krivulya Yu.S. , Bozhenova I.V.
Published: January 2022

Целью исследования явилось изучение проявлений эпидемического процесса эхинококкоза среди населения Оренбургской области. Заболеваемость изучалась за 1994–2012 гг. по различным источникам — официальным данным и данным лечебно-профилактических учреждений области, в которых проводится оперативное лечение эхинококкоза. Проведено серологическое исследование образцов сыворотки крови лиц, ранее не болевших эхинококкозом, и генетическое типирование эхинококков методом полимеразной цепной реакции. Получено расхождение показателей заболеваемости по данным разных источников. Заболеваемость эхинококкозом населения Оренбургской области, по данным медицинских учреждений хирургического профиля, достоверно превышала регистрируемую заболеваемость и имела тенденцию к росту. Не выявлено достоверных различий между показателями заболеваемости взрослого и детского населения. Заболеваемость эхинококкозом среди лиц отдельных групп и профессий (животноводы, пастухи, охотники и члены их семей) не имела достоверных различий с заболеваемостью остального взрослого населения. В районах области, где показатель заболеваемости был достоверно выше среднеобластного, серопревалентность эхинококкоза также была достоверно выше, чем на остальных территориях. От людей и животных выделен один штамм эхинококка — G1 (общий, домашних овец).
Щодо діагностики нейросифілісу в інфекційному стаціонарі
Authors: Domashenko O.M. , Mantula A.O. , Sliusar O.O. , Aksionova M.A. , Matisko М.O.
Published: January 2022

Наведений клінічний випадок нейросифілісу, який був діагностований у інфекційному стаціонарі. Клінічна симптоматика пізнього нейросифілісу має неспецифічний характер, проте особливістю перебігу є відсутність гарячки та інтоксикації, білково-клітинна дисоціація в лікворі. Критерієм ефективності терапії є нормалізація показників спинномозкової рідини при негативних специфічних серологічних реакціях (мiкропреципiтацiї, iмунофлюоресценцiї). У лікуванні нейросифілісу використовують високодозову безперервну антибіотикотерапію під контролем аналізу спинномозкової рідини.
The Issue of Overusing Antibiotics in Cattle in the US Food Industry
Authors: Tao Jingjing
Published: January 2022

The misuse of antibiotics in cattle production in the United States deserves more public recognition and regulatory intervention. Antibiotics are used by cattle farmers not just for treating cattle illnesses, but mostly to increase profits and earnings. Antibiotic abuse is not unique in the United States. It has already happened on a global scale, with the United States being one classical example. To deal with overusing antibiotics in cattle, one way is to settle limitation requirements by federal agencies. The other approach is to impose taxes on antibiotics applied in cattle production. Advantages and disadvantages are identified for the two solutions respectively. The best option is determined by the event’s timing and character, as well as the country’s specific conditions.
Recycle Plastic Waste Brick
Authors: Manas Divyarth
Published: January 2022

Abstract: Disposal of large quantity of plastic waste has emerged as an important environmental challenge, and its recycling is facing a big problem due to non-degradable nature. Due to plastic does not decompose biologically, the amount of plastic waste in our surroundings is steadily increasing. The proposed sand bricks which is made up by adding plastic waste in crush form in sand bricks may help to reuse the plastic waste as one of the additives material of bricks, and to help the disposal problem of plastic waste. The properties of plastic bricks which contain varying percentages of plastic were tested for compressive strength, water absorption and efflorescence. It shows that an appreciable improvement in the performance of bricks can be achieved by introducing crush type of plastic waste into plastic bricks. In view of utilization of plastic waste material for developing sustainable construction material, the present paper reviews plastic waste materials in different compositions of 0% to 20% that were added to the raw material to develop plastic waste bricks. The compression strength of the bricks is reviewed and recommendations are suggested as the outcome of the study. It was found that the reduction in compressive strength, due to replacement of plastic by waste plastic waste, is minimal and can be enhanced by addition of super plasticizer. The water absorption and efflorescence however showed excellent performance Keywords: Plastic Waste, Compressive Strength, Water Absorption, Efflorescence, Environmental Issue
Text Summarizer Using Julia
Authors: Thakur Amey
Published: January 2022

Abstract: The purpose of this paper is to introduce the Julia programming language with a concentration on Text Summarization. An extractive summarization algorithm is used for summarizing. Julia's evolution and features, as well as comparisons to other programming languages, are briefly discussed. The system's operation is depicted in a flow diagram, which illustrates the processes of sentence selection. Keywords: Text Summarizer, Extractive Summarization, Sentence Score, Topic Representation, Julia Programming Language
Child Immunization: Knowledge among Mothers in a North Karnataka Hospital
Authors: John Nimmy N , John N Stanley , JV Midhunya , Doddayya H.
Published: January 2022

Aim of the study: Immunization can be considered as a boon to the human kind as it helps to eradicate diseases. It has contributed to curtailing the mortality of children under-5 years in India. Giving awareness to the parents is the first and foremost factor to achieve the goal.

Methods and Materials: This study is carried out for a period of 8 months at Navodaya Medical College Hospital & Research Centre, Raichur on the title “Knowledge of Mothers about the Children Immunization Status in Pediatric Inpatient and Outpatient Department” and the sample size was 2000 mothers who have visited department of paediatric with their children.

Result: It was observed that only 60% of the mothers were having knowledge about BCG, Hep A, Hep B, DTP and Polio. Although it is a fairly good knowledge score, the mothers were not informed about the need, dosing schedule of many vaccines.

Conclusion: Our study concluded that the extent of knowledge, attitude and practice of parents about child vaccination is very important. This study reflects that the majority of the respondents were having only partial knowledge about vaccination. The reason could be poor education and low awareness about immunization and vaccines in rural areas.

Keywords:  Immunization, vaccine, awareness, paediatric.
Recent Development in Floating Drug Delivery System: An Overview
Authors: Chaudhary Sachin , Dua J.S. , Prasad D.N.
Published: January 2022

Floating medicines work well to increase drug absorption in the stomach. On the basis of current literature, a drug for a novel drug delivery system (NDDS) is established to explicate the floating drug delivery system (FDDS). The most recent FDDS progress involves the formulation as well as physiological aspects that may affect gastric retention and formulation. This review also discusses certain ways of producing a floating system, as well as evaluation methods, characterization, and classification for the FDDS pharmaceutical dosage form. By overcoming physiological hurdles such as short stomach residence times and unexpected gastric emptying times, scientific and technological achievements have been made in the study and development of controlled-release oral drug delivery systems in recent years. So, in general, float dose systems are key technological medication delivery systems that have a stomach-retentive nature and provide a variety of options. Floating drug delivery systems (FDDS), also known as hydro dynamically balanced systems (HBS), swelling and expanding systems, polymeric bio-adhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices are now used to extend the GRT. The latest technological breakthroughs of FDDS, including patented delivery methods and commercialized products, are covered in this study, as well as their advantages and future possibilities for oral controlled drug administration.

Keywords- A novel drug gastrointestinal tract, types of FDDS, gastric residence time, evaluation of FDDS
Rapid disintegrating tablets: an effective method for accelerating the therapeutic action of poorly soluble Drugs
Authors: Joshi Apeksha , Gahelot Narendra , Jain Vikas , Mahajan SC
Published: January 2022

The ease of administration and increased patient compliance are critical factors in the design of oral drug delivery systems, which continue to be the dominant method of drug delivery despite numerous shortcomings. The rapid disintegrating tablet (RDT) could be a great alternative to traditional tablets because it dissolves quickly when it comes into contact with saliva. Rapid disintegrating tablets (RDTs) are currently more widely available than other tablets to treat various disorders. Due to its ease of manufacture and administration, oral administration is being investigated as the most frequently used route. Due to its rapid disintegration features, water-free use, and simplicity of swallowing, RDTs, particularly for pediatric patients, are effective drug delivery devices. Rapid disintegrating tablets are solid dosage forms that disintegrate in the mouth without water in less than 60 seconds. Rapid disintegration of tablets results in rapid dissolution and, thus, immediate action. The primary objective of this review paper is to discuss the benefits, drawbacks, formulation issues, manufacturing methods, patented technology and evaluation tests. Spray drying, freeze drying, direct compression, moulding, and sublimation are all traditional ways of preparation, however new technologies have been created for the production of RDTs.

Keywords: Rapid disintegrating tablets, patient compliance, spray drying, freeze drying, direct compression.
Assessment of Drug Utilization Pattern and Rational Use of Antihypertensive Therapy in Geriatric Patients: A Prospective Observational Study
Authors: Viswanatha Swamy AHM , R Mahindra Kumar , Nyamagoud Sanat , James Jaseen , James Jesmitha , Siby Manna , Mathews Anit
Published: January 2022

Background: Hypertension is one of the most frequently occurring noncommunicable diseases, and it causes a variety of cardiovascular complications and mortality. Diagnosis and treatment in elderly patients are very difficult due to their changes in physiology and physiological responses to the therapy. Drug utilization studies are plausible instrument in the evaluation in health care practice. Objective: To assess drug utilization pattern and rational use of antihypertensive therapy in geriatric patients. Materials and methods:  This is a prospective observational study that took place in 200 inpatients over the course of six months. The study includes subjects with age group of 65 years and above with all comorbidities. The collected data was statistically evaluated by appropriate descriptive statistical analysis. Here the prescription pattern and rationality were analysed. Results: In this study out of 200 patients, 53% of prescriptions contain combination therapy and remaining 47% contains mono therapy. Most commonly prescribed class as mono therapy was Calcium channel blockers 79. 00% (Amlodipine). Among two drug regimen Calcium channel blockers + Diuretics and the three-drug regimen Calcium channel blockers + Angiotensin Receptor Blocker + Diuretic combination are generally prescribed. Here the overall rate of adherence to JNC 8 is 95%. Conclusion:  In this study by analysing prescription pattern, we concluded that most commonly prescribed drug class was Calcium channel blockers (Amlodipine). The present study results demonstrate that, most of the physicians are adherent to the JNC 8 recommendations.

Keywords: Antihypertensive drugs, Adherence to JNC 8, Rational use, Prescription patterns.
MERCADO INTERNO (NACIONAL) E EXTERNO (EXPORTADOR): AS EMPRESAS TÊM COERÊNCIA NO DISCURSO EM SUAS ATITUDES “DITAS SUSTENTÁVEIS”?
Authors: Santi Thiago , Ferreira Denize Minatti , Ferreira Janaína Da Silva
Published: January 2022

A extração de recursos naturais e o tratamento dado a eles causam prejuízos ambientais e, consequentemente, afetam o modo de vida das pessoas. Dessa forma, este estudo analisa a coerência do discurso das 28 empresas listadas no Índice de Sustentabilidade Empresarial da Brasil, Bolsa, Balcão (ISE B3). A metodologia segrega a amostra em dois grupos: as que exportam e as que comercializam no mercado interno e aplica a análise de conteúdo (BARDIN, 2011) no discurso das empresas e nas ações que declaram ser “sustentáveis”. Os achados evidenciaram que as empresas parecem transparecer serem sustentáveis e coerentes, além do que as exportadoras possuem mais coerência em suas respostas, pela declaração de iniciativas, como projetos sociais para a comunidade, além de medidas de controle e de conscientização para que utilizem recursos naturais de forma racional. Ainda, os resultados contribuem para que os stakeholders tenham melhor visão da coerência do discurso das empresas com as quais possuem ligação, além de saberem quais são as preocupações das mesmas com a sustentabilidade, seja para investidores, que buscam empresas comprometidas, clientes, para que saibam os impactos dos produtos consumidos e serviços prestados, além de outros diferentes públicos que se relacionam com as empresas.
Blue Hills and distant music: images of prison and freedom in children’s and autobiographical literature of Great Britain and Russia (estate context)
Authors:   A.M. Gorky Institute of World Literature of Russian Academy of Sciences, Veligorsky Georgy A.
Published: January 2022

In the second half of the 19th century, under the influence of romanticism, the dichotomy “town — village” (and its variant “town — estate”), one of the oldest dichotomies of adult literature, penetrates into the children’s literature of Great Britain. Opposed to each other, the village and the town are displayed in it as closed spaces that have their own boundaries and allow for the possibility of moving from one to another, not infrequently taking the form of an escape. This dichotomy entails a rich metaphor, a gallery of images that embody the border between two worlds, as well as beckon to overstep the limit. It also gives rise to a new type of character known as “a naughty child” and developing in the works of the authors of this period we are analyzing (R.L. Stevenson, R. Jefferies, K. Grahame, B. Potter). Within the framework of the article, we will systematize these images, as well as trace their analogues in the children’s and the autobiographical literature in Russia.
Hermeneutical Experience in the Novel ‛The Life of Arseniev’ by Ivan Bunin
Authors:   Belarusian State University of Transport, Nizova Olga V.
Published: January 2022

The paper attempts to apply the categories and methods of German hermeneutics of the beginning and the middle of the 20th century, such as understanding of life, sympathetic re-living (W. Dilthey), being-in-the-world, being-with (M. Heidegger), dialogue with tradition, hermeneutic experience (H.-G. Gadamer) and others, to analysis of a famous lyrical novel, “The Life of Arseniev” by Ivan Bunin, to the extent of their correspondence to the philosophical content of the book. The autobiographical self-knowledge in the novel is considered in relation to the same experience expressed in Goethe’s “From My Life: Poetry and Truth”; the paper also describes the hermeneutical situation of the creation of an “autobiography of a fictional person”, traces the influence of Hindu culture, Orthodoxy and Catholicism in the hero’s understanding of the world; notes the cyclic character of time; reveals the love and beauty being the ontological characteristics of the world in the novel; shows the expansion of existence in sympathetic reliving of the past as well as the possibility of being-in-the-world as a poetic being; considers the hero’s acquisition of vocation, the choice of lifestyle and environment as well as the self-examination and self-reflection phenomena as the modes of self-knowledge experience; juxtaposes the understanding of life of the Bunin’s to with the Heidegger’s hermeneutics of factuality.
‛Here is the Work of a True Master’: Emigrant Critics on Ivan Bunin’s Novel ‛The Life of Arseniev’ (1928–1952)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Bakuntsev Anton V.
Published: January 2022

The paper covers the critical reception of Ivan Bunin’s novel “The Life of Arseniev” in 1928–1952 considering a large empirical material presented by more than 50 responses of emigrant critics to “The Life of Arseniev” – including its parts (books) published in the “Sovremennye zapiski” magazine in 1928–1929 and 1933, and to book publications published in 1930, 1939 and 1952. The variety of critical points of view on the form and content of “The Life of Arseniev”, its significance and place in Russian and world literature are represented for a first time in a coherent and systematic way. The empirical material grouping is based on the chronology of publication of Bunin’s novel both in periodicals and as separate publications. The principle of historicism and the comparative analysis were the main research methods. Based on the research, the author concludes that it was emigrant criticism that outlined the main ways of the following scientific understanding of “The Life of Arseniev”.
The French Essay ‛La Vie et l’OEuvre d’Ivan Bunin’ (‛The Life and Work of Ivan Bunin’, 1969) by Georgy Adamovich
Authors:   Jean Moulin Lyon 3 University, Garziano Svetlana A.
Published: January 2022

This work is dedicated to the essay “La vie et l’oeuvre d’Ivan Bunin” (“The life and work of Ivan Bunin”), written by Georgy Adamovich in French for a French reader and published in 1963 (republ. in 1967, 1969, 1970, 1971) in the “Collection of the Nobel Prizes in Literature Laureats”. This twenty-eight page text is rather little known, it is not mentioned either in L. Livak’s bibliographic book, or in “Classics without Retouching. The Literary World about the Work of Ivan Bunin” collection. The analysis of the text “La vie et l’oeuvre d’Ivan Bunin” is coupled with its translationreconstruction into Russian, based on the theoretical views Adamovich had on the practice of translation expressed in the essay “In Memory of Baudelaire”, in the preface to the translation of “The Stranger” novel by A. Camus and in the essay “About us and the French. A few comments on the translation of ‘Anabasis’, the poem by Saint-John Perse”. In the French essay, it is possible to find many references to key moments in the history of Russian literature (Russian classics of the 19th century, literature of the early 20th century, the fundamental figures of Fyodor Dostoevsky and Leo Tolstoy, Ivan Turgenev, Anton Chekhov, Maxim Gorky). It is worth noting that Pushkin’s heritage is not mentioned in the French text. The essay especially touches upon the image of Bunin as a poet and at the same time mentions Alexander Blok, a signature name for the poetry of the beginning of the 20th century. The French article will be compared with other texts of Adamovich about the work of Ivan Bunin: essays from the collection “Loneliness and Freedom” (“Bunin”, “More about Bunin”), “Bunin as a poet”, “Memories”.
Bunin and Berberova: The Plot of Returning to the Homeland (To the Problem of Dialogue between the Classics and Young Writers)
Authors:   National Research Tomsk State University, Khatyamova Marina A.
Published: January 2022

The paper analyzes Berberova’s complex attitude to Bunin based on the autobiography “My Italics” and the story “Rocanval: a Chronicle of a Castle” (1936), which refers to the “Non-Urgent Spring” by the plot of a return to the past and the narrative creation; it is noted that in the story “The Late Hour” (1938) an opposite influence is also found — Bunin’s textual dialogue with Berberova’s the “Biyankur Manuscript” (1930): the topos of Berberova’s “late hour”, a lonely journey to the city of childhood, placed in Bunin’s story in a strong position, exposes the polemical intention of the author, who seeks to be heard by the young authors. However, the semantics of the ‘return’ plot in the works of the writers of different generations and aesthetic approaches varies: Bunin adheres to poetic semantics, asserting the triumph of creative Memory, while Berberova – to the dystopian, eliminating the central emigrant myth. The textual dialogue between Bunin and Berberova testifies to the classic’s interest in the prose of an aspiring writer and, more broadly, in the work of young expatriate authors.
‛In Search of Lost Time’. On the Traces of Memories of I. Bunin and V. Nabokov
Authors:   University Lorand Etvesh, Racz Ildiko Maria
Published: January 2022

Memory is like art: a creative, constructive act, which is perfectly felt in the works of Ivan Bunin and Vladimir Nabokov. The kinship of memory with creativity is also confirmed by the fact that the inner emotional world of the creative subject is decisive in both processes. One of the points of connection and particular sensitivity of the art of Bunin and Nabokov is precisely the fact that they do not believe in time. The time of consciousness is also separated from the physically measurable time of reason in Nabokov’s first novel and Bunin’s story “Mitya’s Love”. In the world of their heroes a key role belongs to various forms of manifestation of memory: individual, historical, and even archaic. The connection with the past expands the boundaries of the personal existence of their heroes, allows the individual to feel himself part of the One Whole. Bunin’s characters, who embodied the ideal of eternal feminine, tend to come to life in memory as well. And like the rose of Jericho, in the stories of Bunin written in exile the historical Russia also comes to life again, becoming a timeless theme of historical memory. The act of remembrance moves us away from the present, thanks to it, we can relive the past with a “living life”.
‛Spiritualization of Matter’: Ivan Bunin in French Literary Criticism and in Translations by Boris Schloezer
Authors:   Université de Strasbourg, Victoroff Tatiana V.
Published: January 2022

Boris de Schloezer, leading literary critic in Russian émigré and French journals (“Sovremennye Zapiski” (“Contemporary Notes”), “La Revue Musicale”, “La Nouvelle Revue Française”) wrote several reviews of the work of Ivan Bunin and in в 1929 translated a collection of his early short stories as well as those written in the emigration (“La Nuit”, éd. Émile-Paul Frères). A mediator between Bunin and the French intellectual world, instrumental for his acquaintance with André Gide, his being invited to the conferences of European writers in Pontigny (Les Décades de Pontigny), his contacts with the French publishing house Stock. Schloezer as translator aims at make real the “spiritualization of matter” — the main feature, in his opinion, of Bunin’s poetics — by means of French terms, rendering the original music, intonations and rhythm. Thanks to a perfect knowledge of both Russian and French and to direct contact with the author, the translation was created according to the laws of artistic oeuvre, based on the model of Bunin’s freely emerging words. The appendix contains a first translation into Russian of Schloezer’s review of Bunin for “La Nouvelle Revue Française”; letters to Ivan Bunin from Boris Schloezer, Benjamin Crémieux, Paul Desjardins, André Gide, Jacques Rivière, and Dumesnil de Gramont (Russian Archive in Leeds), as well as letters from Ivan Bunin to the French publisher Stock, Maurice Delamain.
Ivan Bunin as an Interpreter of Adam Mickiewicz’s Crimean Sonnets
Authors:   Gorlovka Institute оf Foreign Languages of Donbas State Pedagogical University, Zhuzhgina-Allahverdyan Tamara N.
Published: January 2022

The paper analyzes the Polish sonnets translated by I. Bunin that is well known as an interpreter of English and American romantic literature, the author of a classic translation of the “Song of Hiawatha” by H.W. Longfellow. Less known and studied are Bunin’s translations of A.B. Mickiewicz’s sonnets — “Akkerman steppes”, “Chatyrdag” and “Alushta at night”. Developing his own concept of literary translation, Bunin inherited the poetic tendencies of the past century, the rules of accentual-syllabic arrangement of a sonnet that had developed in Russian versification, and the peculiarities of Mickiewicz’s Crimean poems as “travel notes” dating back to P.A. Vyazemsky. As a result of a comparative analysis of the Polish and Bunian texts, we find a two-pronged approach to verse translation and interpretation — on the one hand, the accuracy of the world image and strict adherence to the Russian sonnet structure, on the other, freedom of expression through the stylistics and emphatics of the native Russian language.
Application of Inquiry Learning Model with Lesson Study (LS) Pattern on Student Learning Outcomes in Colloid System Material
Authors: Wahyuni Nur H. , Suherman Suherman , Tahril Tahril
Published: January 2022

This study aimed to know the effect of applying the inquiry learning model with lesson study (LS) pattern on student learning outcomes in colloid system material in class XI SMA Negeri 1 Sigi. This type of research was a quasi-experiment with an equivalent post-test design. Samples were determined by the purposive sampling method. The sample used in this study was students of class XI MIA 3 as an experimental class with 24 students and XI MIA 4 students as a control class with 20 students. The processing of student learning outcomes data used a non-parametric analysis of the Mann-Whitney U-Test test. The results showed that the mean value of the experimental class was higher than the control class, which was 23.98>15.82. Results of statistical analysis sig. 2-tailed was (0.019) <0.05 and Zcalculation (-2.336) < Ztable (-1.96), based on decision-making criteria, it stated if the value of -Zcalculation<Ztable then H0 is rejected. Therefore, it can be concluded that there is the effect of applying the inquiry learning model with lesson study (LS) pattern on student learning outcomes in colloid system material in class XI SMA Negeri 1 Sigi.
Pre-service Chemistry Teachers’ Mental Model of Colligative Properties for Nonelectrolyte Solutions
Authors: Sinaga Kelly , Sitinjak Debora S. , Purba Friska J.
Published: January 2022

Mental models are representations that describe the understanding of the three levels of representation in chemistry, that is macroscopic, sub-microscopic, and symbolic. This study aims to obtain a general description of the mental model of pre-service chemistry teachers in the colligative properties of non-electrolyte solutions. The study was a descriptive research with 22 second-year FIP Chemistry Education students from Pelita Harapan University Tangerang. Data collection was carried out with research instruments in the form of diagnostic tests. The results of the study state that the average percentage level of representation is 67 % macroscopic level, 31% sub-microscopic level, and 72 % symbolic level. The results of this study indicate that students' understanding at the macroscopic and sub-microscopic level of the colligative properties of non-electrolyte solutions was low compared to chemical representations at a symbolic level. Meanwhile, the categories of mental models possessed by pre-service chemistry teachers in the topic of non-electrolyte colligative properties vary for each level of chemical representation. Based on the percentage at each level of representation, the mental model of chemistry teacher candidates with a symbolic model category is higher than the scientific model. The low mental model of the scientific model contributed to the understanding of the pre-service chemistry teachers that the concept of chemistry is not intact scientifically.
Misconceptions Reduction of Science High School Students on Buffer through Remedial Using Conceptual Change
Authors: Kurnia Anna , Santoso Tri
Published: January 2022

This study aimed to analyze the results of the reduction of misconceptions among SMA Negeri 5 Palu students on the buffer material using the conceptual change learning strategy. This research is a type of pre-experimental research with a research design that is One group pretest-posttest design. This study contained one experimental group, namely students whose learning outcomes did not reach the minimum completeness criteria (MCC), then given a pre-test to determine the initial state of the experimental group, then given treatment, and given a post-test. Testing student misconceptions data using CRI. The results showed that the average percentage of students, who knew the concept (KC), did not know the concept (DKC), and misconceptions (MC) before the application of conceptual change learning strategies were 38.1%, 45.2%, and 16, respectively. 6% and the percentage of students knowing the concept (TC), not knowing the concept (NKC), and misconception (MC) after the application conceptual change learning strategies respectively 87.4%, 12.6%, and 0%. In conclusion, the average percentage reduction in misconceptions of grade XI IPA SMA Negeri 5 Palu on the buffer through remedial using the conceptual change learning strategy was 16.6%
The Analysis of the Honesty and Responsibility Characters of Chemistry Education Study Program Students on Examinations
Authors: Suherman Suherman , Rahmawati Sitti , Mustapa Kasmudin , Poba Detris , Azizah Nur
Published: January 2022

Honesty and responsibility should be a principle held by students. But, there are still problems of dishonesty and irresponsibility of students during exams. This study aimed to analyze the honesty and responsibility character of chemistry students during exams. The research samples were 39 students. Data were collected by observation and interviews technique, by using observation and questionnaires sheets. Data were analyzed by using descriptive statistics. The results showed that the honesty and responsibility of chemistry students were in the sufficient category where the percentage of honesty and responsibility of students based on the observation sheets was 43.6% and 49%, respectively. While the questionnaire responsibility students were 46.2% and 43.6%, respectively.