bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical Fingerprinting, PAHs Characterization and Ecological Risks of Carcinogenic PAHs in Surficial Sediments of Egi Crude Oil Producing Communities, Niger-Delta, Nigeria
Authors: Ndubuisi Iwuoha Godson , Imoh Oritsebinone Esther
Published: October 2024

In order to do PAHs rings analysis, its source identification, extent to which cPAHs present and what kind of ecological risk they pose, the surface sediments from various freshwaters in the Egi crude oil producing cities in the Niger Delta, Nigeria were analyzed. Sediments collected from the research areas for PAHs loadings (in mg/kg dry weight) ranged from 0.020 to 1.790, 0.050 to 1.880, and 0.020 to 1.640, respectively for Obite, Obagi, and Ibewa cluster areas, as measured by gas chromatography-mass spectrometer. In these clusters, the respective average concentration of the three dominant carcinogenic PAHs were Indeno(1,2,3-cd)pyrene (1.170.0mg/kg), Dibenz[a,h]anthrancene (0.870.0 mg/kg), and Dibenz[a,h]anthrancene (1.3670 mg/kg) for Ibewa, Obagi and Obite cluster areas. The findings showed that dominant PAHs rings are of high molecular weight (HMW) PAHs in these sediments are, 5 member rings, which are benzo(b)fluoranthene, Benzo(k)fluoranthene, and Benzo(a)pyrène, and 6-member ring which are, Indeno(1,2,3-cd)pyrene, Dibenz[a,h]anthrancene, and Benzo[ghi] perylene, respectively. Their fingerprints points majorly to pyrogenic sources, combustion of coal, biomass, petroleum, and other related anthropogenic petroleum activities as the primary source of PAHs in the environment. Notably, the RQNCs and RQMPCs for single PAHs molecule are both less than 1, it means the contamination it generates is considered of low ecological risk. Again, the research area experiences frequent flooding, it is believed that this contributes to the low ecological risk of PAHs chemical pollution. Consequently, the area is deemed to be quite safe.
Post-Partum Depression: A Case Study of the Wife of an Expatriate Pakistani
Authors: Rasheed Ayesha
Published: October 2024

This study aims to explore the experience of post-partum depression in a woman that is the wife of an expatriate Pakistani. It probes into the psycho-social factor that boost the chances of past-partum depression among woman who gone through the c-section while giving birth to her 4th child in her husband’s absence while living in joint family system. This case study reported a woman with postpartum depression; facing psychosocial pressures while living in joint family system in rural area of Punjab. Edinburgh post-natal depression scale used to analyse her post-partum depression and DSM- V as the determinant of diagnostic criteria which revealed that psychosocial pressures, attachment issues and lack of social support made her vulnerable. Postpartum depression has varying symptoms and psycho-social factors irritating its symptoms.
Studi Literatur: Kemampuan Pembuktian Matematis Mahasiswa Pada Pembelajaran Matematika
Authors: Hajar Marhani  , Rusi Ulfa Hasanah  , M. Fahrozi Tanjung
Published: October 2024

The purpose of this research is to find out about students' mathematical abilities and proofs when learning mathematics at the tertiary level. In this research, researchers used quantitative methods in the form of literature reviews or literature reviews, namely this research took data sources from books, journals and previous research that had been carried out. Apart from that, it is also based on the results of the researcher's analysis, where this theoretical reference can be used as a strong basis for understanding students' mathematical proof abilities. Based on the research results obtained by researchers, it is that students' mathematical proof abilities are not optimal, and based on the research results, the percentage of mathematical proof abilities obtained is less than optimal. The majority of students still have difficulty working on proof questions. This is due to various factors, one of which is that understanding of integers and their definitions and properties is still low.
Analisis Berpikir Komputasi Siswa Dalam Menyelesaikan Permasalahan Matematika
Authors: Mayang Nabila  , Yahfizham Yahfizham
Published: October 2024

Computational thinking is a way of thinking that students must have. Currently, many students do not yet know how computing can be applied in mathematics learning. For this reason, this research focuses on analyzing students' computational thinking in solving mathematical problems. This research takes the type of literature study research by identifying and evaluating the results of previous research. Data analysis was carried out using an interactive model which uses 4 steps in the analysis stages, namely: 1) Data collection, 2) Data condensation, 3) Data presentation and 4) Data verification. This research identified 3 previous articles. From the results of this research, it is found that computational thinking in solving mathematical problems can still be said to be not very good..
Analisis Kesulitan Belajar Peserta Didik Terhadap Materi Matematika, Khususnya Dalam Perkalian Berbentuk Cerita Di Kelas II Sekolah Dasar
Authors: Elizabeth Agnesia Manik  , Yeri Lestari Gulo  , Adrias Adrias  , Nur Azmi Alwi
Published: October 2024

Students who have difficulty learning mathematics will often make mistakes in learning to count and mistakes in solving word problems in mathematics. The difficulties experienced by students are difficulty in working on story problems due to the inability to understand the meaning of the questions and confusion when determining what arithmetic operations will be used to solve the story problems. The purpose of this research was to analyze the learning difficulties experienced by students as well as the factors that caused students’ learning difficulties in working on multiplication questions in the form of stories in class II elementary school. The method used in this research is descriptive case study. The subjects of this research are students and teachers of class II A at SDN 15 ULU GADUT. The data collection procedures used in the research are test’s, interviews, observation and documentation. The results of the research show that difficulties in learning mathematics include: 1) Difficulty in distinguishing multiplication problems from other material, 2) Student’s writing cannot be read, 3) Difficulty doing calculations in solving multiplication problems. Internal factors include: 1) Lack of enthusiasm for studying, 2) Low numeracy skills and difficulty understanding questions, 3) Not focusing on studying. External factors include: 1) Lack of attention from parents, 2) Often asking students to memorize multiplication, 3) Not using interesting learning media in teaching.
Analisis Pemahaman Konsep Matematika Kelas X AKL SMKS SEMESTA Depok pada Materi Logaritma
Authors: Putri Khairani  , Ika Nur Bella Fitriyani  , Yogi Arif Fathan
Published: October 2024

Concept mastery is the level of learning outcomes where students can explain or define lesson concepts using their own sentences or parts of them. This research approach uses a qualitative descriptive method. Qualitative research is about describing the meaning of data or phenomena that can be captured by researchers, by showing evidence. The meaning of this phenomenon depends a lot on the researcher's ability and sharpness in analyzing (Abdussamad, 2021: 30-31). The results obtained from this research come from documentation data. From the documentation data, 24 students will analyze the understanding of mathematical concepts in class X AKL SMKS SEMESTA, Depok. The results per category can be concluded that there are 15 respondents or 64% of students who have a high level of ability to understand mathematical concepts in logarithm material with high criteria, then there are 7 respondents or 29% of students who have a level of ability to understand mathematical concepts of logarithm material with medium criteria, and there are 2 respondents or 8% of students who have a low level of ability to understand mathematical concepts regarding logarithm material..
Pengembangan Media Pembelajaran Math Card (Kartu Matematika) Dalam Pembelajaran Matematika Materi Eksponen, SPLDV, Aritmatika
Authors: Andika M. Faris  , Damar Wisnu Saputro  , Dina Rubiati
Published: October 2024

Math Card is a card-based board game that contains questions for mathematics learning media. The purpose of the Math Card is to make it easier and more interesting for students in math lessons to make it more fun. This research uses the ADDIE method, namely analysis, design, development, implementation, and evaluation.  At the analysis stage, analysis is carried out related to material needs by following per under the syllabus/curriculum and design needs to get design results that attract the attention of students. At the design stage, the design is carried out according to the needs of the Math Card, namely by designing cards, packaging, guidebooks, and game boards. The development stage is to develop the results of the material and design, namely compiling questions according to the syllabus and printing products. The implementation stage is to conduct trials for grade 10 SMK students in the classroom. The last is the evaluation stage, namely by improving and perfecting the Math Card learning method to be more effective and efficient.
Hambatan Kognitif Siswa Sekolah Dasar dalam Memahami Konsep Kecepatan dan Debit
Authors: Mutiara Azhar Batubara  , Winda Septiana Sianturi  , Sry Hafiza Hasibuan  , Ratu Bulqish Indriani  , Rika Pratiwi Pasaribu  , Elvi Mailani  , Maya Alemina Ketaren
Published: October 2024

Students who have academic difficulties are a sign that something is wrong. These errors can be in the form of conceptual misunderstandings, errors in forgetting the solution procedure, or careless errors. Therefore, the purpose of this study was to determine the cognitive barriers that elementary school students must overcome to understand the concept of speed and discharge. The methodology used in this study was qualitative. A literature search revealed that poor cognitive development of students, who are often at the concrete operational stage, is the main cause of these obstacles. Additional obstacles noted include proportionality challenges, limited abstraction and imagery capacity, and learning strategies that do not help the process of understanding the topic effectively.
Program pembelajaran bagi peserta didik autis di Raudhatul Athfal Maestro NU Purbalingga
Authors: Muayyadah Muayyadah
Published: October 2024

The study conducted at Raudhatul Athfal NU Maestro Purbalingga outlines the learning program for autistic students in group A as well as the problems faced by teachers in the 2022/2023 school year. This type of research is descriptive qualitative. The subjects of this study consisted of a class teacher and a group A student who had been detected as autistic. Data collection was done through interviews and observations. The data obtained was tested for validity by increasing persistence, triangulation, and using reference materials. Data analysis techniques were carried out by collecting data, reducing data, presenting data, and drawing conclusions. Without special preparation, autistic students joined their classmates. Teachers use various learning approaches, such as games and movements, and adjust their schedules accordingly. Due to limited electronic means, learning media is more traditional. Standardized adjustments for autistic children are used to conduct holistic evaluations. The absence of special preparation, the absence of a dedicated space, and the difficulty of handling and evaluating autistic students, which interferes with the overall learning process, are the main obstacles.
Transformasi Digital Pendidikan Islam: Pemanfaatan Laravel dalam Pengembangan Sistem Informasi Akademik di TPA Mesjid Al-Jama’ah Padang
Authors: Asri Ervan , Yance Sonatha  , Putri Dinda Meivianti Dwi
Published: October 2024

Managing academic information in educational institutions often faces challenges that require high efficiency. Manual processes in collecting and managing academic data can lead to complexity and errors. Taman Pendidikan Al-Qur’an (TPA) Mesjid Al-Jama’ah in Padang experiences similar issues, particularly in managing registration, attendance, grades, and tuition payments. This research aims to develop an Academic Information System based on Laravel for TPA Mesjid Al-Jama’ah, encompassing four user levels: admin, prospective students, students, and teachers.
The Rapid Application Development (RAD) methodology is used in system development, involving stages such as requirements determination, prototyping, development and feedback collection, and product implementation and finalization. The system is built using UML, PHP, Laravel, and MySQL to ensure data is well-organized and free from redundancy. The implementation results indicate that this system facilitates online registration and data management, and helps teachers input grades and attendance efficiently. It is recommended that the system be further developed to include TPA financial management and add features for printing summaries and exporting data to Excel, to enhance the efficiency and effectiveness of information management at TPA Mesjid Al-Jama’ah.
Analisis Usability Testing pada Sistem Informasi Dokumentasi dan Pelaporan Akreditasi
Authors: Zahra Suci Khairatuz , Yulherniwati  , Hadi Ronal
Published: October 2024

Akreditasi Program Studi merupakan upaya peningkatan mutu pelayanan perguruan tinggi yang dapat diwujudkan dengan membangun sistem informasi dan budaya mutu. Penelitian ini ditujukan untuk membuat sebuah sistem informasi yang mampu menampung dokumentasi dan pelaporan  akreditasi di Jurusan Teknologi Informasi, dan melakukan analisis usability testing dengan system usability scale (SUS) dan user interview. Hasil penelitian menunjukkan rata-rata skor SUS adalah 65. Skor ini menunjukkan bahwa pengguna bisa menerima sistem informasi yang berbasis pada aspek kegunaannya. Namun, peningkatan kualitas aplikasi masih diperlukan, karena skor kegunaan juga menunjukkan bahwa kualitas aplikasi masih pada tingkat D. Evaluasi untuk meningkatkan kualitas aplikasi dapat dimulai dengan memperbaiki aspek kesalahan dan kepuasan pada sistem informasi.
Visualization Of Spatial Distribution Of Village Development Index A Review Of Location Data In West Java Province
Authors: Riadi Bambang , Hermawan Erwin , Hadiyat Yayan
Published: October 2024

The spatial distribution of the Village Development Index (IDM) is the result of village development analysis for the purposes of mapping and assessing variations in the level of village development results in a region. The aim of the research is to analyze the spatial distribution of IDM, which is a comprehensive indicator that covers social, economic and environmental aspects in assessing village development progress. The methodology used in this research includes spatial analysis using a spatial data integration system with secondary data (statistical data). The combination of the internet of things (IoT) with WebGIS makes it possible to integrate data from various sources, in the form of spatial and non-spatial data into one easily accessible platform. This allows for more in-depth and accurate data analysis; and it is possible to disseminate information quickly and widely because it can be accessed by various stakeholders. That spatial distribution of the IDM can be used as an important tool in planning for a more inclusive and sustainable regional development. With WebGIS, data collected from IoT devices can be processed and analyzed to producing interactive maps and reports that will help in a better decision-making process, the research results can be accessed at https://jabar-e.netlify.app.
Debt Risk Analysis of Automotive Enterprises
Authors: Chap Sovanhangmeas  , Liu Junyan
Published: October 2024

In order to maintain their financial stability, businesses must recognize and manage the financial risks that are necessarily involved in their operations and output. Businesses may better comprehend their financial status and undertake efficient risk early warning by examining financial indicators. Academic research on the detection and mitigation of financial risks is extensive, and in an effort to increase the accuracy of assessments, an increasing number of academics are using multi-indicator systems for thorough analysis. Furthermore, non-statistical techniques including hierarchical analysis, B-S option pricing models, and artificial neural networks have shown extremely effective at handling complicated data and non-linear connections. As the economy transitions from high to medium-high growth, traditional and new energy vehicles in the automobile sector confront significant possibilities and problems. Traditional automakers aggressively converting to new energy cars include SAIC Motor, BAIC Group, and GAC Group. Companies that produce new energy vehicles, such XPeng, BYD, Tesla, Li Auto, and NIO, are becoming more competitive by developing new technologies and tapping into new markets. To enhance market competitiveness and sustainability, businesses must address issues like excessive inventory and price volatility that have been brought about by the new energy vehicle market’s explosive expansion through efficient financial risk management. The short- and long-term debt repayment capacities of traditional and new energy vehicle (NEV) enterprises are the main subjects of this study’s analysis of their financial statements. According to the findings, traditional automakers have more stable financial circumstances whereas NEV enterprises exhibit stronger short-term solvency and lower long-term financial risk in specific years with superior liquidity and lower debt ratios. The study attempts to offer resources for the automobile industry’s deleveraging, sustainable development, and inventory reduction.
Modern trends in the training of library and information specialists
Authors: Maslak Volodymyr , Fedorenko Svitlana , Butko Larysa
Published: October 2024

Global transformations necessitate a re-evaluation of training models for library and information specialists and the modernisation of educational programmes to meet new professional challenges and competencies, including entrepreneurial skills. The aim of the article is to analyse the conditions for ensuring the development of entrepreneurial competence elements among bachelor’s degree students in the specialty 029 “Information, Library and Archival Affairs” at higher education institutions in Ukraine through the lens of evolutionary transformations in higher library and information science education. The research employs a systematic approach, including analysis, synthesis, generalisation, and various analytical methods. Effective professional training in the library and information field relies on adapting educational programmes to rapidly evolving professional demands. Analysis of educational programmes at four institutions shows their potential to develop entrepreneurial skills through a variety of mandatory and elective courses, fostering competencies such as creative thinking, management, communication, and teamwork. Mastery of these skills is increasingly crucial for modern library and information professionals. It has been found that the compulsory educational components as well as the elective educational components from the catalogue of elective disciplines, selected from the educational programmes to assess the development of entrepreneurial competence in future specialists, highlight the uniqueness of each programme and reflect the educational institution’s overall approach to training bachelor’s students in this field. It is noted that the list of compulsory and elective educational components, according to a particular educational and professional programme, demonstrates a positive tendency in understanding the current needs of the industry and social requirements in general. The research results can be used to improve the content and structure of educational programmes for training specialists in the specialty 029 “Information, Library and Archival Affairs”, as well as to develop new syllabi and working programmes for educational components
A Study the Water Quality Measuring Equipment with Automatic Sensor System
Authors:   National University of Laos, NAMAVONG Ten
Published: October 2024

This paper studied the water quality in Dong Khoai Village, Xaythani District, Vientiane Capital, which is the primary water pumping location for agriculture. The area has a population of over 1735 citizens and cover more than 450 hectares. Common issue found in Markhiaw river. Stream is its toxicity to certain rice field, causing it inability to grow rice despite using fertilizer. Furthermore, this stream gives dissatisfaction odor, negatively affects people who get into the water for fishing and occasionally found death fish in the areas. In order to assess the water quality and disseminate the results to the public. Therefore, this study aims to investigate the creating of an automated sensor system for high precision water quality monitoring in the water. Four sensors; pH (hydrogen potential), EC (electro conductivity), TDS (total dissolved solid), and temperature are used in this procedure. The sensor system was tested, and build a small station uses solar energy and saves information into the SD card and available online by Blynk, and compare the test results with national environmental standards. The research revealed that, in comparison to the standard instrument S5 pro parameter, the measuring stations for the water quality values of all four sensors are accuracy value of 92.91% to 99.34%. Based on the information gathered over the course of two months, from February 13 and March 18, the pH value will be low, at 5. The pH value is high, at 11, between 13, 17 and 18 February 2024. These numbers are considered to be in the standard ranks. Regarding the dissolved solids in the water vary from 3 to 100 mg/L, and the electrical conductivity is between 100 and 180 µS/cm. They are also fall upon the National Environmental Standard. The Temperature value is high, at 40.81 ºC on 4 February 2024 and from 02 March 2024, the Temperature value will be low, at 24.4ºC.
Diversity of Bird Species in Training and Model Forest of Faculty of Forestry Science, National University of Laos A case study of Napo Village, Sangthong District, Vientiane Capital
Authors:   Souphanouvong University, Ackhavong Somsanook
Published: October 2024

This research are the objectives to study the diversity of bird species in 3 different forest areas: forest plantation area, agricultural land and natural forest area. Which the tools used in the study are the interviews with people who found types of bird species in the area and direct survey belong point transects or point count with take note and then analyzed by formula frequency ratio and dominant ratio. From the interview, there are 53 species of birds, 43 genus and 9 orders in the study area as forest plantation area of 30 species, 24 genus, 6 orders, agricultural land area of 31 species, 24 genus, 9 orders, and nature forest area of 12 species, 10 genus, 3 orders. From the actual survey in 3 areas it was found that there are 49 bird species, 37 genus and 11 orders. Species were not found in the survey but found in the interview of 17 species, 16 genus, 7 orders, and species found outside of the interview of 15 species, 14 genus, 6 orders. In that there are 2 species in the prohibited category of poultry or his list 1, namely: the Nokkotpeut (Centropus sinensis), and the KaiKuaNin (Lophura diardi), but from the actual survey it was found only by the NokkotPeut (Centropus sinensis), As for the KaiKuaNin (Lophura diardi) is not found, Status by Threatened Species List of IUCN and aquatic and wildlife list of Laos: 7 species and 1 species on the list (1) of 2008 aquatic and wildlife.
PROMOVENDO O BEM-ESTAR PSICOLÓGICO: ESTRATÉGIAS DE PREVENÇÃO DE DEPRESSÃO EM IDOSOS DE 60 A 80 ANOS
Authors:   Pedro Henrique Rodrigues Alencar, Araújo Ane Caroline Amarante , Lima José Rikelme Barbosa , Rodrigues Naiara Dos Santos , Silva Naiara Dos Santos , Ferraz Paloma Marinho
Published: October 2024

Aging is a normal and natural phase of society's development, deeply linked to health and illness conditions, and influenced by neurobiological, genetic, functional, and sociocultural factors. Quality of life plays a central role in characterizing aging as healthy or pathological, making it clear that an individual's psychological health is a result of the context in which he or she lives. Therefore, this study aimed to analyze the nursing strategies adopted to prevent depression in elderly individuals aged 60 to 80 years. This is a narrative review study, carried out through research in the Virtual Health Library (VHL) and Google Scholar, using the following descriptors: depression AND elderly AND nursing AND prevention. The eligibility criteria adopted were: complete works that addressed the topic between the years 2019 and 2024. Dissertations, theses, theoretical essays, and experience reports were excluded. In the end, eight studies were selected. Among the strategies used by nurses, the following are mentioned: encouraging the maintenance of Activities of Daily Living (ADLs); encouraging the active participation of the social support network; keeping the home environment well ventilated; cleaning and disinfecting frequently touched surfaces, such as bed headboards, remote controls, doorknobs, cell phones and canes, with 70% alcohol; and promoting a healthy diet, accompanied by good fluid intake, as priority measures to reduce the chances of contamination by COVID-19. Thus, it is concluded that health professionals need to redefine the provision of care and attention to the elderly in health services, in addition to promoting the training of the nursing team to meet gerontological needs more adequately.
Titelblatt, Impressum, Inhalt
Authors: N.N.
Published: October 2024

No abstract available
6 Şubat 2023 Kahramanmaraş Depreminde Tetiklenen Değirmencik Heyelanı (Gaziantep – İslahiye)
Authors: Turkmen Sedat
Published: October 2024

6.02.2023 saat 04:17’de Doğu Anadolu Fay Zonu’nun uzantısı konumunda bulunan ve merkez üssü Pazarcık (Kahramanmaraş) ilçesinde aletsel büyüklüğü (Mw) 7,7 ve odak derinliği 8,6 km olan deprem, 11 ili etkilemiş ve yüzlerce kilometrelik yüzey kırığı oluşturmuştur. Bu depremin artçıları devam ederken aynı günün 9 saat sonrasında yine Doğu Anadolu Fay Zonu’nun bir diğer segmenti üzerindeki Sürgü-Çardak fayı üzerinde saat 13:24’te yaklaşık bir dakika süre boyunca Elbistan (Kahramanmaraş) ilçesinde aletsel büyüklüğü (Mw) 7,6 ve odak derinliği 7.0 km olan ikinci bir deprem daha meydana gelmiştir. İlk depremde bir çok yüzey deformasyonu oluşmuş ve geniş bir bölgede yüzlerce km uzunluğunda yüzey kırığı, depremin tetiklediği büyük çaplı heyelanlar ve bir çok bölgede kaya düşmeleri meydana gelmiştir. Ayrıca yine depremin etkisi sunucu sıvılaşmaya bağlı yanal yayılmalar oluşmuştur. Meydana gelen heyelanların en büyüklerinden biri Gaziantep’in İslahiye ilçesi, güneyindeki Değirmencik Mahallesinin batısındaki İdilli vadisinin kuzey yamacında meydana gelen akma şeklindeki heyelandır. Bu çalışmada İdilli vadisi heyelanı incelenmiş, heyelanı tetikleyen ana etkenin jeolojik özelliklerin yanında bu bölgelerde deprem sonucu oluşan yüksek yatay yer ivmesi değerleri olduğudur. Ayrıca mevsimsel olarak yeraltı suyunun varlığı ve yamaç eğiminin kaymada etkili olduğu söylenebilir.
Meningkatkan Skill Komunikasi Bahasa Arab pada Murid Kelas V SD dengan Metode Seni Peran
Authors: Chalifah Lailil , Muid Faruq Abdul
Published: October 2024

Penelitian ini mengeksplorasi bagaimana metode seni peran untuk meningkatkan kemampuan komunikasi bahasa Arab pada murid kelas lima sekolah dasar. Studi dilakukan dengan 40 murid dibagi menjadi kelompok kontrol dan kelompok perlakuan. Hasil menunjukkan peningkatan signifikan dalam pengucapan kata, kosakata, dan kefasihan berbicara pada kelompok yang mengikuti metode seni peran. Siswa juga merespons positif terhadap metode ini, menunjukkan peningkatan motivasi dan partisipasi aktif dalam pembelajaran. Penelitian ini mendukung integrasi seni peran sebagai alternatif efektif dalam pembelajaran bahasa Arab di sekolah dasar.
Strategi Pembelajaran Inovatif dalam Pendidikan Inklusif di Sekolah Dasar
Authors: Mellymayanti Hani , Nurfadhillah Septy , Nuraeni Yeni
Published: October 2024

Penelitian ini dilatarbelakangi oleh tantangan dalam implementasi pendidikan inklusif di SD Negeri Karawaci 3 Kota Tangerang, yang mengharuskan penyesuaian strategi pembelajaran untuk siswa dengan kebutuhan khusus. Tujuan penelitian adalah untuk mengevaluasi efektivitas strategi pembelajaran inovatif dalam konteks pendidikan inklusif. Metode yang digunakan adalah pendekatan kualitatif dengan observasi dan wawancara mendalam terhadap guru dan siswa. Hasil penelitian menunjukkan bahwa penerapan strategi scaffolding, yang melibatkan penyesuaian individu dan penyediaan waktu khusus bagi siswa ABK, secara signifikan meningkatkan keterlibatan dan harga diri siswa. Metode ini memungkinkan siswa ABK untuk mengejar ketertinggalan mereka melalui bimbingan khusus dan partisipasi aktif dalam aktivitas pembelajaran. Pembahasan dominan menekankan pentingnya keterlibatan langsung siswa dalam pembelajaran dan penyesuaian materi sesuai dengan kebutuhan spesifik mereka. Kesimpulan dari penelitian ini adalah bahwa strategi pembelajaran inovatif yang adaptif dan individual dapat meningkatkan kualitas pendidikan inklusif, namun memerlukan pelatihan berkelanjutan bagi guru dan evaluasi yang mendalam untuk mencapai hasil optimal.
Desenlaces materno-perinatales en unapoblación de gestantes con infección porCOVID-19 en un hospital de Lima, Perú
Authors: Gamarra Díaz Nancy , Urbina Alvarez Claudia Aracelli , La Rosa De Los Ríos Mauricio , Pascual Chirinos Rivera Jorge Martín
Published: October 2024

Introduction: COVID-19 has impacted obstetric field, affecting pregnant women with risks such as preterm birth, preeclampsia, and perinatal complications. Objective: To describe the characteristics of a population of pregnant women with COVID-19 infection, the characteristics of their newborns, and perinatal outcomes at National Hospital Edgardo Rebagliati between March and June 2020, Lima, Peru. Materials and methods: Observational cross-sectional study, from March to June 2020. All pregnant women who arrived at the obstetricemergency and were hospitalized at the Rebagliati Hospital were included and underwent an immunochromatography test for IgM/IgG to determine the seroprevalence of COVID-19 and/ or PCR. Obstetric and perinatal variables were collected in a data sheet on admission to the emergency room and hospitalization. Results: Rapid test for SARS-CoV-2 was performed in 108 pregnant women hospitalized for delivery, 106 singleton pregnancies (98%) and 2 twins(2%). The average age was 31 years, with 1% of adolescents and 33% over 35 years; 46% ofdeliveries were vaginal, 18,5% of them preterm; 37% of the pregnant women were symptomatic and 7,4% were admitted to the intensive care unit. 91,8% of the newborns weighed between 2500 and 3999g, 51% were female, 93,5 % had Apgar greater than 7 at one minute and 100% with negative swabbing in newborns within the first 24 to 72 hours. Conclusion: Most of the pregnant women were asymptomatic and 3 out of 100 pregnant women had respiratorycomplications. The prevalence of cesarean section was low in relation to other publications, 2 of the newborns had positive swabs with possible horizontal transmission.
Recent Advances in Maturation of Induced pluripotent Stem Cells-derived Cardiomyocytes
Authors: Zhao Junting , Hao Richard
Published: October 2024

Induced pluripotent stem cells -derived cardiomyocytes (iPSC-CMs) increasingly become an important tool for studying genetic heart diseases, drug screening and heart cell therapy. However, iPSC-CMs differentiated by the traditional ways are immature and the challenge of producing fully matured iPSC-CMs that functionally resemble adult cardiomyocytes persists. Immature iPSC-CMs exhibit characteristics typical of fetal-stage cells, including less developed contractility, electrophysiological properties, and metabolic processes. These limitations restrict their clinical applications, especially in regenerative medicine. Over the past decade, numerous strategies have been developed to enhance the maturation of iPSC-CMs. These include prolonged culture periods, biochemical induction using specific hormones and energy substrates, and the application of biophysical stimuli such as electrical and mechanical stimulation. In addition, advances in biomaterials, such as extracellular matrices and hydrogels, have been crucial in replicating the physiological environment needed to support iPSC-CM development. Together, these methods aim to produce cardiomyocytes that more closely mimic adult heart cells in structure and function. This review explores recent progress in optimizing the maturation of iPSC-CMs and highlights their potential impact on future applications in cell therapy and heart disease modeling.
Os impactos da pandemia da Covid-19 no cotidiano e na saúde da população idosa
Authors: Duarte Rafael Bezerra , Batista Natália Gurgel , Lima Bruna Oliveira , De Abreu Leidy Dayane Paiva , Limeira Clélia Patrícia da Silva , De Souza Celestina Elba Sobral , Marinho Mirna Neyara Alexandre de Sá Barreto , Da Silva Maria Rocineide Ferreira
Published: October 2024

Esta pesquisa objetiva analisar as produções científicas acerca dos impactos da pandemia da Covid-19 no cotidiano e na saúde da população idosa. Trata-se de uma revisão integrativa, realizada no período de março a abril de 2022, em meio a plataforma da Biblioteca Virtual em Saúde, e na base de dados da Scientific Electronic Library Online. Foram incluídos nesta revisão vinte e três (23) artigos completos, disponíveis eletronicamente, publicados na língua portuguesa no período de 2020 a 2022, no formato de artigos científicos. Frente aos resultados pode-se evidenciar que a pandemia da Covid-19 desencadeou sérios impactos sobre a vida e saúde da população idosa, tendo por destaque, mudanças de rotinas, causando prejuízo na realização das atividades básicas e instrumentais de vida diária, distanciamento de amigos e familiares, padrão de sono prejudicado, afastamento e perda de emprego, aumento da violência, declínio das capacidades funcionais e cognitivas. Pode-se ainda identificar impactos na saúde mental, onde os sentimentos de solidão, ansiedade, tristeza, medo, assim como problemas de depressão se destacaram. Além disso, evidenciou-se a piora no estado de saúde, pois, muitos idosos tiveram dificuldades em dar continuidade aos tratamentos, e por falta de acompanhamento médico. Portanto, espera-se uma maior mobilização por parte de órgãos governamentais e dos profissionais da saúde, para assim, encontrarem possíveis caminhos para que os cuidados em saúde aconteçam de forma segura e eficaz, objetivando diminuir os impactos negativos deixados pela pandemia da Covid-19 na vida e na saúde da população idosa.
Proteomic and functional comparison between human induced and embryonic stem cells
Authors: Brenes Alejandro J , Griesser Eva , Sinclair Linda V , Davidson Lindsay , Prescott Alan R , Singh Francois , Hogg Elizabeth KJ , Espejo-Serrano Carmen , Jiang Hao , Yoshikawa Harunori , Platani Melpomeni , Swedlow Jason , Findlay Greg M , Cantrell Doreen A , Lamond Angus I
Published: October 2024

Human induced pluripotent stem cells (hiPSCs) have great potential to be used as alternatives to embryonic stem cells (hESCs) in regenerative medicine and disease modelling, thereby avoiding many of the ethical issues arising from the use of embryo-derived cells. However, despite clear similarities between the two cell types, it is likely they are not identical. In this study, we characterise the proteomes of multiple hiPSC and hESC lines derived from independent donors. We find that while hESCs and hiPSCs express a near identical set of proteins, they show consistent quantitative differences in the expression levels of a wide subset of proteins.hiPSCs have increased total protein content, while maintaining a comparable cell cycle profile to hESCs. The proteomic data show hiPSCs have significantly increased abundance of vital cytoplasmic and mitochondrial proteins required to sustain high growth rates, including nutrient transporters and metabolic proteins, which correlated with phenotypic differences between hiPSCs and hESCs. Thus, higher levels of glutamine transporters correlated with increased glutamine uptake, while higher levels of proteins involved in lipid synthesis correlated with increased lipid droplet formation. Some of the biggest metabolic changes were seen in proteins involved in mitochondrial metabolism, with corresponding enhanced mitochondrial potential, shown experimentally using high-resolution respirometry. hiPSCs also produced higher levels of secreted proteins, including ECM components and growth factors, some with known tumorigenic properties, as well as proteins involved in the inhibition of the immune system. Our data indicate that reprogramming of human fibroblasts to iPSCs effectively restores protein expression in cell nuclei to a state comparable to hESCs, but does not similarly restore the profile of cytoplasmic and mitochondrial proteins, with consequences for cell phenotypes affecting growth and metabolism. The data improve understanding of the molecular differences between induced and embryonic stem cells, with implications for potential risks and benefits for their use in future disease modelling and therapeutic applications.
The relationship between virtual simulation, critical thinking, and self-directed learning abilities of nursing students in Riyadh, Saudi Arabia
Authors: Alharbi Hanan F. , Alsubaie Amjad , Gharawi Rahaf , Ba Mazroo Rawan , Alajaleen Shaikhah , Alsultan Munerah , Alsaleem Munira , Alsubihi Nora , Alsahli Norah , Alqahtani Nashwa , Rayzah Raghad
Published: October 2024

Objective

The use of virtual simulation in nursing education is an effective approach for improving nursing critical thinking and self-learning abilities, but the previous studies were limited to providing the required evidence that supports the association. This study aimed to assess the relationship between virtual simulation and critical thinking disposition and self-directed learning abilities among nursing students.

Methods

This is a descriptive correlational, non-experimental study. It was conducted among 201 third- and fourth-year nursing students at the Academic Institution, Saudi Arabia. A non-probability convenience sampling technique was used to select the participants; then, an online, adapted questionnaire was sent to the participants, the data from which was analyzed by SPSS.

Results

The study findings showed that virtual simulation benefited nursing students. Most participants (56%) agreed that it helped them to think critically, and approximately 27% strongly agreed. It also enhanced their self-directed learning abilities, and the majority of the students agreed that they often review the way nursing practice is conducted. Furthermore, the results showed a significant, positive relationship between virtual simulation and the critical thinking disposition of nursing students (p-value = 0.03; correlation coefficient = 0.65), a strong positive relationship with self-directed learning abilities of nursing students (p-value = 0.004; correlation coefficient = 0.78), and a strong positive relationship between critical thinking disposition with self-directed learning abilities of nursing students (p-value = 0.01; correlation coefficient = 0.72).

Conclusion

There are significant relationships between virtual simulation and the critical thinking disposition and self-directed learning abilities of nursing students. Furthermore, virtual simulation made the students practice critical thinking and self-learning, so, they simulate events and try to seek out and solve the problems.
Pdk3’s role in RANKL-induced osteoclast differentiation: insights from a bone marrow macrophage model
Authors: Zhang Nan , Wang Lingting , Ye Xuxin
Published: October 2024

Background

Osteoporosis (OP) is a chronic disease characterized by decreased bone mass, loss of skeletal structural integrity and increased susceptibility to fracture. Available studies have shown that the pyruvate dehydrogenase kinase (PDK) family is associated with osteoclastogenesis and bone loss, but the specific role of Pdk3 in bone pathology has not been systematically investigated.

Methods

A cell OP model was established in receptor activator for nuclear factor-κB Ligand (RANKL)-induced bone marrow macrophages (BMMs). Hereafter, the expression levels of Pdk3 and osteoclastogenesis feature genes including nuclear factor of activated T cells 1 (Nfatc1), Cathepsin K (Ctsk), osteoclast associated Ig-like receptor (Oscar) in BMMs-derived osteoclasts were examined based on real-time quantitative PCR and western blotting methods. Further, the phosphorylation of ERK, P65 and JAK/STAT and their correlation was Pdk3 was gauged. In particular, changes in the activity of these signaling pathways were observed by silencing experiments of the Pdk3 gene (using small interfering RNA). Finally, the effects of Pdk3 gene silencing on signaling pathway activity, osteoclastogenesis, and related inflammatory and apoptotic indicators were observed by transfection with PDK3-specific siRNA.

Results

Following RANKL exposure, the levels of Pdk3 and osteoclastogenesis feature genes were all elevated, and a positive correlation between Pdk3 and osteoclastogenesis feature genes was seen. Meanwhile, ERK, P65 and JAK/STAT phosphorylation was increased by RANKL, and Pdk3 was confirmed to be positively correlated with the phosphorylation of ERK, P65 and JAK/STAT. Additionally, in RANKL-exposed osteoclasts, Pdk3 knockdown diminished the phosphorylation of ERK, P65 and JAK/STAT, reduced the expressions of osteoclastogenesis feature genes. Importantly, knockdown of Pdk3 also reduced the expression of inflammatory cytokines and resulted in elevated levels of Bax and Casp3 expression, as well as downregulation of Bcl2 expression.

Conclusion

This study reveals for the first time the role of Pdk3 in RANKL-induced osteoclastogenesis and OP. These findings provide a foundation for future studies on the role of Pdk3 in other bone diseases and provide new ideas for the development of OP therapeutics targeting Pdk3.
EFFECTIVE AYURVEDIC APPROACH IN THE MANAGEMENT OF PCOS: A CASE REPORT
Authors: Biswas Anupam , Tiwari Swadha , Tiwari Shomya , Bhaduri Tapas
Published: October 2024

Nowadays, cases of Polycystic Ovarian Syndrome (PCOS) are rising very significantly, generally present in younger age groups due to faulty food habits, lifestyle, stress, etc. PCOS is a disease characterised by menstrual irregularities, elevated androgen levels and multiple cysts on one or both ovaries. A complex process is maintained by the intact uterine-adnexa and the hypothalamic-pituitary-ovarian axis in the female reproductive system. The normal functioning of the human body depends on the interdependence of all its systems, and any imbalance in one can lead to multisystem pathology. It is a common endocrinopathy, a multifactorial and polygenic condition resulting in anovulation or oligo-ovulation. In Ayurvedic classics, clinical features present in PCOS can be co-related with Pushpaghni Jataharini, Artavakshaya and Gulma roga. A 25-year-old female visited the OPD with complaints of irregular menstrual cycle, pimples and hair loss from the last six months. USG revealed Bilateral polycystic ovarian morphology. Oral administrations of shamana aushadhi have been done for three months. Regular menstrual cycles, along with improvements in symptoms, have been observed. Evidence for the complete cure of PCOS has produced an intriguing and positive outcome for researchers and professionals in this sector by following the principle of Gulma chikitsa. Shamana aushadhi, like Kanchanara Guggulu, Vriddhivadhika vati, Kumaryasava and Pathya churna, have shown excellent results in managing Polycystic Ovarian Syndrome.
A GUDA AGNIKARMA FOR THE MANAGEMENT OF MANYASTAMBHAA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLOSIS: A CASE STUDY
Authors: Marathe Pushpak R , Gundre Rajesh N , Gadve Babasaheb N
Published: October 2024

Background: Manyastambhaa, akin to cervical spondylosis in modern medicine, is prevalent due to lifestyle factors such as poor posture and stress. It is characterized by stiffness and neck pain, and it significantly negatively influences quality of life, especially in the elderly. The slight relief that conventional treatments provide often leads to the investigating of alternative therapies. Methodology: The 67-year-old male patient in this case study has persistent neck discomfort, stiffness, and sensory abnormalities that are not improving with allopathic medicine. The patient received a parasurgical Ayurvedic treatment called Guda Agnikarma therapy. Over ten days, sessions were held on alternate days. The Visual Analog Scale (VAS) and range-of-motion assessments were among the subjective and objective methods used to evaluate pain, stiffness, and discomfort. Observation: After the treatment, there was a noticeable improvement. There was a significant reduction in stiffness and a noticeable discomfort alleviation from severe to none. Flexion, extension, lateral flexion and rotation substantially improved range of motion. Conclusions: Guda Agnikarma showed promise in reducing cervical spondylosis symptoms by acting as an analgesic, reducing inflammation, and relaxing muscles. The method is suitable for outpatient settings, minimally invasive, and reasonably priced. These results point to Guda Agnikarma as a potential treatment for Manyastambhaa, indicating that more research is necessary to confirm its effectiveness and incorporate it into general therapeutic practice.
A CLINICAL STUDY OF DADRUGHAN TAIL IN THE MANAGEMENT OF DADRU KUSTHA ROGA
Authors: Goyal Yashdeep , Pandey SD
Published: October 2024

Introduction: Dadru was described under Shudra kustha roga by Acharya Charak and Maha kustha roga by Acharya Sushruta. It is Kapha-Pitta pradhan twak roga. It is prevalent these days. Aim: To check Dadrughan Tail's efficacy in managing Dadru Kustha Roga. Method: 30 patients who fulfilled the inclusion criteria were selected based on signs and symptoms of Dadru Kustha Roga. Diagnosis: It was made based on signs and symptoms explained in the classic and modern textbooks like kandu (itching), raga (erythema/redness), pidika (eruptions), size of the mandala (lesion), utsanna mandala (elevated circular patches) etc. Drug: Dadrughan Tail was made of 7 drugs, which were selected according to their features mentioned in different Ayurvedic textbooks. The oil was prepared according to Sharangdhara Samhita. It was prepared for external use only. Follow-up: All the patients were examined on the 1st day (before starting the treatment) and were recalled for the 1st follow-up on the 7th day (after starting the treatment). Results: There was 85.56% improvement in the symptoms of kandu, 79.44% in raga, 82.78% in pidika, 76.11% in size of mandala, 76.11% in numbers of mandala, 79.44% in utsana mandala, 73.89% in prasaran, 88.33% in rukshata, 87.80% in daha, 90.48% in sarava and 50.00% in associated symptoms. Conclusion: The overall improvement in the group was 80.17%; this shows that Dadrughan Tail effectively managed Dadru Kustha Roga.