bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis
Authors: Grund Thomas , Goyon Stephanie , Li Yuting , Eliava Marina , Liu Haikun , Charlet Alexandre , Grinevich Valery , Neumann Inga D.
Published: December 2017

Neuropeptides, such as neuropeptide S (NPS) and oxytocin (OXT), represent potential options for the treatment of anxiety disorders due to their potent anxiolytic profile. In this study, we aimed to reveal the mechanisms underlying the behavioral action of NPS, and present a chain of evidence that the effects of NPS within the hypothalamic paraventricular nucleus (PVN) are mediated via actions on local OXT neurons in male Wistar rats. First, retrograde studies identified NPS fibers originating in the brainstem locus coeruleus, and projecting to the PVN. FACS identified prominent NPS receptor expression in PVN-OXT neurons. Using genetically encoded calcium indicators, we further demonstrated that NPS reliably induces a transient increase in intracellular Ca2+concentration in a subpopulation of OXT neurons, an effect mediated by NPS receptor. In addition, intracerebroventricular (i.c.v.) NPS evoked a significant somatodendritic release of OXT within the PVN as assessed by microdialysis in combination with a highly sensitive radioimmunoassay. Finally, we could show that the anxiolytic effect of NPS seen after i.c.v. or intra-PVN infusion requires responsive OXT neurons of the PVN and locally released OXT. Thus, pharmacological blockade of OXT receptors as well as chemogenetic silencing of OXT neurons within the PVN prevented the effect of synthetic NPS. In conclusion, our results indicate a significant role of the OXT system in mediating the effects of NPS on anxiety, and fill an important gap in our understanding of brain neuropeptide interactions in the context of regulation of emotional behavior within the hypothalamus.

SIGNIFICANCE STATEMENTGiven the rising scientific interest in neuropeptide research in the context of emotional and stress-related behaviors, our findings demonstrate a novel intrahypothalamic mechanism involving paraventricular oxytocin neurons that express the neuropeptide S receptor. These neurons respond with transient Ca2+increase and somatodendritic oxytocin release following neuropeptide S stimulation. Thereby, oxytocin neurons seem essential for neuropeptide S-induced anxiolysis, as this effect was blocked by pharmacological and chemogenetic inhibition of the oxytocin system.
17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females
Authors: Oberlander Joseph G. , Woolley Catherine S.
Published: December 2017

Estradiol (E2) acutely potentiates glutamatergic synaptic transmission in the hippocampus of both male and female rats. Here, we investigated whether E2-induced synaptic potentiation occurs via presynaptic and/or postsynaptic mechanisms and which estrogen receptors (ERs) mediate E2's effects in each sex. Whole-cell voltage-clamp recordings of mEPSCs in CA1 pyramidal neurons showed that E2 increases both mEPSC frequency and amplitude within minutes, but often in different cells. This indicated that both presynaptic and postsynaptic mechanisms are involved, but that they occur largely at different synapses. Two-photon (2p) glutamate uncaging at individual dendritic spines showed that E2 increases the amplitude of uncaging-evoked EPSCs (2pEPSCs) and calcium transients (2pCaTs) at a subset of spines on a dendrite, demonstrating synapse specificity of E2's postsynaptic effects. All of these results were essentially the same in males and females. However, additional experiments using ER-selective agonists indicated sex differences in the mechanisms underlying E2-induced potentiation. In males, an ERβ agonist mimicked the postsynaptic effects of E2 to increase mEPSC, 2pEPSC, and 2pCaT amplitude, whereas in females, these effects were mimicked by an agonist of G protein-coupled ER-1. The presynaptic effect of E2, increased mEPSC frequency, was mimicked by an ERα agonist in males, whereas in females, an ERβ agonist increased mEPSC frequency. Thus, E2 acutely potentiates glutamatergic synapses similarly in both sexes, but distinct ER subtypes mediate the presynaptic and postsynaptic aspects of potentiation in each sex. This indicates a latent sex difference in which different molecular mechanisms converge to the same functional endpoint in males versus females.

SIGNIFICANCE STATEMENTSome sex differences in the brain may be latent differences, in which the same functional endpoint is achieved through distinct underlying mechanisms in males versus females. Here we report a latent sex difference in molecular regulation of excitatory synapses in the hippocampus. The steroid 17β-estradiol is known to acutely potentiate glutamatergic synaptic transmission in both sexes. We find that this occurs through a combination of increased presynaptic glutamate release probability and increased postsynaptic sensitivity to glutamate in both sexes, but that distinct estrogen receptor subtypes underlie each aspect of potentiation in each sex. These results indicate that therapeutics targeting a specific estrogen receptor subtype or its downstream signaling would likely affect synaptic transmission differently in the hippocampus of each sex.
Neural Representations of Hierarchical Rule Sets: The Human Control System Represents Rules Irrespective of the Hierarchical Level to Which They Belong
Authors: Pischedda Doris , Görgen Kai , Haynes John-Dylan , Reverberi Carlo
Published: December 2017

Humans use rules to organize their actions to achieve specific goals. Although simple rules that link a sensory stimulus to one response may suffice in some situations, often, the application of multiple, hierarchically organized rules is required. Recent theories suggest that progressively higher level rules are encoded along an anterior-to-posterior gradient within PFC. Although some evidence supports the existence of such a functional gradient, other studies argue for a lesser degree of specialization within PFC. We used fMRI to investigate whether rules at different hierarchical levels are represented at distinct locations in the brain or encoded by a single system. Thirty-seven male and female participants represented and applied hierarchical rule sets containing one lower-level stimulus–response rule and one higher-level selection rule. We used multivariate pattern analysis to investigate directly the representation of rules at each hierarchical level in absence of information about rules from other levels or other task-related information, thus providing a clear identification of low- and high-level rule representations. We could decode low- and high-level rules from local patterns of brain activity within a wide frontoparietal network. However, no significant difference existed between regions encoding representations of rules from both levels except for precentral gyrus, which represented only low-level rule information. Our findings show that the brain represents conditional rules regardless of their level in the explored hierarchy, so the human control system did not organize task representation according to this dimension. Our paradigm represents a promising approach to identifying critical principles that shape this control system.

SIGNIFICANCE STATEMENTSeveral recent studies investigating the organization of the human control system propose that rules at different control levels are organized along an anterior-to-posterior gradient within PFC. In this study, we used multivariate pattern analysis to explore independently the representation of formally identical conditional rules belonging to different levels of a cognitive hierarchy and provide for the first time a clear identification of low- and high-level rule representations. We found no major spatial differences between regions encoding rules from different hierarchical levels. This suggests that the human brain does not use levels in the investigated hierarchy as a topographical organization principle to represent rules controlling our behavior. Our paradigm represents a promising approach to identifying which principles are critical.
The prevalence of long-term oral anticoagulation therapy in a cardiology center in Bucharest, Romania
Authors: Sorescu Adelina-Mihaela , Enache Tudor , Guberna Suzana
Published: December 2017

Background and aims. Few studies discuss the prevalence of oral anticoagulation therapy (OAT) in clinical practice, despite their increasing use worldwide. In America, studies established that 20% to 80% of the patients with indication benefit from OAT. In Romania, there is no data regarding the utilization of oral anticoagulants. Thus, this study aims to determine the trends of OAT.Methods. We designed a cross-sectional study of the patients admitted to the Cardiology Department of the “Bagdasar-Arseni” Clinical Emergency Hospital, Bucharest, from the 1st of November 2016 until the 31st of January 2017. We considered OAT indications to be: atrial fibrillation/flutter (AF), pulmonary embolisms (PE), deep vein thrombosis (DVT), intramural or intracavitary thrombi and left ventricle aneurysms. Statistical analysis was performed with EpiInfo.Results. There were 783 patients admitted, 253 of these having an OAT indication (mean age 73.25 years, 53.75% female). Only 162 patients (64.03%) received it, either Vitamin K Antagonists (VKA) (78 patients, 48.14%), or Novel Oral Anticoagulants (NOAC) (84 patients, 51.85%). Reasons for not indicating such therapy included the hemorrhage risk (43.27%), the lack of adherence to the treatment (18.56%), the impossibility of INR monitoring (21.84%), the economic status (10.21%) and others (6.12%). 221 patients had AF (87.35%), 141 (63.8%) receiving OAT, VKA (67 patients, 47.51%), or NOAC (74 patients, 52.48%). 17 patients (6.71%) had a PE and/or DVT. 15 (88.23%) received OAT, AVK (11 patients, 73.33%), or NOAC (4 patients, 26.67%). 15 patients (5.92%) had other OAT indications (excepting AF or PE/DVT), 11 receiving OAT (73.33%), AVK (8 patients, 72.72%), or NOAC (3 patients, 27.27%).Conclusions. Our study determined that 64.03% of those with indication received OAT. Similar data is reported in the USA, suggesting an underuse of anticoagulants. The risk of hemorrhage, lack of adherence, the impossibility of INR monitoring or the economic status were some of the reasons for not recommending OAT.
Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population
Authors: Goidescu Iulian Gabriel , Caracostea Gabriela , Eniu Dan Tudor , Stamatian Florin Vasile
Published: December 2017

Aim. Multigene panel testing for Hereditary Breast and Ovarian Cancer (HBOC) using next generation sequencing is becoming more common in medical care.We report our experience regarding deleterious mutations of high and moderate-risk breast cancer genes (BRCA1/2, TP53, STK11, CDH1, PTEN, PALB2, CHEK2, ATM), as well as more recently identified cancer genes, many of which have increased risk but less well-defined penetrance.Methods. Genetic testing was performed in 130 consecutive cases with breast cancer referred to our clinic for surgical evaluation and who met the 2016 National Comprehensive Cancer Network (NCCN) criteria for genetic testing.Results. 82 patients had pathogenic/likely pathogenic mutations and VUS mutations, and 48 were negative; 36 of the pathogenic mutations were in the high-risk genes and 16 were in the moderate risk genes and only 5 cases in the intermediary risk group.From the VUS mutation group 21 cases were in the intermediary risk group, 9 cases were in the moderate risk group and only 7 cases in high risk group.The most frequent BRCA1 variant was c.3607C>T (7 cases) followed by c.5266dupC and c.4035delA (each in 4 cases). Regarding BRCA-2 mutations we identified c.9371A>T and c.8755-1G>A in 6 cases and we diagnosed VUS mutations in 3 cases.Conclusion. Our study identified 2 mutations in the BRCA1 gene that are less common in the Romanian population, c.3607C>T and c.4035delA. Both variants had particular molecular phenotypes, c.3607C>T variant respecting the triple negative pattern of BRCA1 breast cancer while c.4035delA were Luminal B HER positive.
Incidental findings during follow-up scans in oncological patients
Authors: Caraiani Cosmin , Pop Anamaria , Calin Adriana , Ciobanu Lidia , Militaru Claudia , Berghe Alexandra , Badea Radu
Published: December 2017

Background and aim. To assess the prevalence of incidental findings during follow-up scans of patients with oncologic pathology.Methods. 499 follow-up scans from different patients with cancer pathology were retrospectively analyzed. Findings which were not suspected by the clinician or known from previous scans were considered as incidental lesions. We excluded lesions that were already suspected by the clinician or were already recorded in the patient’s history before the initial computed tomography (CT) scan. The CT scans were performed on two different machines (“Siemens Somatom Sensation, 64 slices, Erlangen, Germany” and “Siemens Somatom Emotion, 16 slices, Erlangen, Germany”).Most of the patients had a native scan followed by a thoraco-abdominal-pelvic image acquisition after the injection of intravenous contrast media.Results. 28% of the patients had unsuspected incidental findings. The prevalence of incidental findings was similar: 56.6% of them were found in men and 43.4% in female patients. In 6 cases (1.2%) the presence of unsuspected pulmonary embolism was discovered. From these cases, 5 (83.3%) had metastatic disease at the moment of the follow-up CT scan and 1 (16.6%) had metastasis-free disease. In 17 patients out of 499 (3.4%) we incidentally made an important discovery which either changed the cancer therapy or required immediate treatment.Conclusion. Incidental findings are not rare in oncological patients and the radiologist has to be aware of their presence in order not to overlook them and to correctly diagnose them.
Fecal transplantation: digestive and extradigestive clinical applications
Authors: Filip Mihaela , Tzaneva Valentina , Dumitrascu Dan L.
Published: December 2017

Background and aim. Fecal transplantation or fecal material transplantation (FMT) became a hot topic in gastroenterology in recent years. Therefore it is important to disseminate the up-to-date information on FMT. The aim of the paper is to review the knowledge on FMT and its clinical applications.Methods. An extensive review of the literature was carried out. Titles from Pubmed were searched and analyzed. A narrative review has been written with emphasis on indications of FMT in different conditions.Results. The guidelines recommend FMT in relapsing infection with Clostridium difficile. Several attempts to use FMT in other conditions have been analyzed. Attempts were recorded in other bowel disorders like IBD, IBS, chronic constipation and even colorectal cancer. The attempt to change the microbiota by FMT in diabetes and obesity represent challenges for the future.Conclusions. Fecal transplantation represents an important therapeutic method, intensively investigated these years. Beside the indication for persistent and recurrent Clostridium difficile infection, several attempts were undertaken in other intestinal diseases and in metabolic conditions. The efficiency of these applications has to be demonstrated.
Et quasi proprium et sanctissimum templum iustitiae consecrare
Authors: Nemes Szilvia
Published: December 2017

A hatodik század talán legnagyobb műgonddal elkészített törvényműve Iustinianus császár nevéhez fűződik. A császár a klasszikus római tradíció helyreállítójaként és a megújult keresztény birodalom első uralkodójaként tekintett magára, és ennek főként rendeleteiben adott hangot. Törvénykönyveinek bevezető rendeleteiben kettős birodalmi célkitűzését, nevezetesen az imperium Romanum visszahódítását és a klasszikus jogtudomány kodifikálását mint Istennek tett szolgálatot jeleníti meg. Iustinianus keresztény kodifikációjának középpontjában a Digesta áll, amelynek a császár különleges szerepet szentelvén, mintegy az igazságosság saját legszentebb templomaként emelte alattvalói fölé.
Solving the unsolvable
Authors: Paoletti Isabella
Published: December 2017

Social workers often confront situations that are practically, legally and morally unsolvable. Storytelling appears to be central to achieving what seems to be unobtainable and unsolvable. Drawing on past research on storytelling within the ethnomethodological tradition, this study aims to examine how storytelling is used in the discussion of very complex and delicate cases by social workers and other professionals. This study is based on data collected for the Aging, Poverty and Social Exclusion (APSE) project, based in Portugal. Through a detailed analysis within an ethnomethodological framework, and informed by conversation analysis of transcripts of inter-professional meetings, the study shows how social workers and other professionals (nurses, policemen, carer coordinators etc.) use stories in fine tuning the details of home visits, clients’ housing conditions and so on. These stories are institutionally framed – that is, they are structured around what is considered right and wrong by a specific institutional gaze. Stories are often used to propose solutions, by telling the stories of similar previous cases. In these stories the professionals highlight their order of relevance and their responsibilities in managing the case. They delineate a sense of direction for social interventions conducted in narrow and tortuous paths, full of pitfalls.
Afterword
Authors: De Fina Anna
Published: December 2017

Commentary: Social workers and users encounters: narrative and accounting practices
GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation
Authors: Hinze Christian , Ruffert Janett , Walentin Katharina , Himmerkus Nina , Nikpey Elham , Tenstad Olav , Wiig Helge , Mutig Kerim , Yurtdas Zeliha Yesim , Klein Janet D. , Sands Jeff M. , Branchi Federica , Schumann Michael , Bachmann Sebastian , Bleich Markus , Schmidt-Ott Kai M.
Published: December 2017

Collecting ducts make up the distal-most tubular segments of the kidney, extending from the cortex, where they connect to the nephron proper, into the medulla, where they release urine into the renal pelvis. During water deprivation, body water preservation is ensured by the selective transepithelial reabsorption of water into the hypertonic medullary interstitium mediated by collecting ducts. The collecting duct epithelium forms tight junctions composed of barrier-enforcing claudins and exhibits a higher transepithelial resistance than other segments of the renal tubule exhibit. However, the functional relevance of this strong collecting duct epithelial barrier is unresolved. Here, we report that collecting duct–specific deletion of an epithelial transcription factor, grainyhead-like 2 (GRHL2), in mice led to reduced expression of tight junction–associated barrier components, reduced collecting duct transepithelial resistance, and defective renal medullary accumulation of sodium and other osmolytes. In vitro, Grhl2-deficient collecting duct cells displayed increased paracellular flux of sodium, chloride, and urea. Consistent with these effects, Grhl2-deficient mice had diabetes insipidus, produced dilute urine, and failed to adequately concentrate their urine after water restriction, resulting in susceptibility to prerenal azotemia. These data indicate a direct functional link between collecting duct epithelial barrier characteristics, which appear to prevent leakage of interstitial osmolytes into urine, and body water homeostasis.
O Selo Casa Azul como política urbana de incentivo à habitação sustentável e sua relação com o direito à cidade
Authors: Alves Daniele da Conceição Matos , Freitas Gustavo Carvalho de , Santos Jorge Luiz Oliveira dos
Published: December 2017

Esse artigo se propõe a avaliar como o Selo Casa Azul da Caixa Econômica Federal (CEF) poderia ser entendido como uma política pública urbana de fomento à habitação sustentável, a partir das diretrizes técnicas dadas aos empreendedores, assim como os incentivos financeiros. Considerando que o incorporador almeje obter esta certificação ambiental, ele necessitaria cumprir requisitos de sustentabilidade enumerados no Programa criado pela Instituição Pública Federal para que, com isso, tenha acesso à linha de financiamento mais favorável. Além de se tratar de um enfoque jurídico, observar-se-á também o cunho social, antropológico, urbanístico e financeiro que o tema requer, dada a sua interdisciplinaridade, tudo com objetivo de identificar se esse Selo de sustentabilidade pode oferecer positiva contribuição no atual desenvolvimento social urbano. Palavras-chave: Políticas Urbanas. Selo Casa Azul. Sustentabilidade.
A paisagem urbana viária na perspectiva do pedestre: estudo da Avenida Nações Unidas em Bauru/SP
Authors: Pichinin Maria Clara Ortega , Foloni Fernanda Moço , Constantino Norma Regina Truppel
Published: December 2017

O uso das ruas no meio urbano foi se transformando conforme às necessidades de seus habitantes. Inicialmente, era exclusivamente voltada para o trânsito de pedestres e transportes de tração animal; no Século XIX, o automóvel começou a se popularizar, alterando gradativamente a função das ruas e a paisagem local para acomodar um novo estilo de vida, cuja qualidade foi decaindo com o passar do tempo. Projetos viários contemporâneos ainda priorizam as ruas para os veículos, reduzindo os espaços de permanência e passagem de pedestres. A Avenida Nações Unidas em Bauru/SP, é um exemplo de via construída especialmente para a expansão urbana e passagem de automóveis, visto que a cidade – entroncamento ferroviário, rodoviário, e polo regional – precisava, segundo a gestão da época, se modernizar para atrair indústrias. O objetivo deste trabalho é analisar como se deu essa transformação da paisagem e esclarecer as consequências da prevalência do espaço urbano para o automóvel, analisando a atratividade da Avenida Nações Unidas e estudando sua paisagem atual. Foram utilizadas bibliografias relacionadas, levantamentos documentais, cartográficos e fotográficos (obtidos em visitas de campo) para traçar os eixos de conexão entre o estudo teórico, as transformações históricas e a atratividade da avenida do ponto de vista do pedestre. Dessa forma, conclui-se a importância do estudo da paisagem (morfologia e população) para projetos viários que retornem o espaço urbano às pessoas. PALAVRAS-CHAVE: Paisagem urbana. Ruas. Bauru/SP.
A influência da tipologia construtiva na ambiência urbana: ilhas de calor
Authors: Melo Ricardo Henryque Reginato Quevedo , Melo Evanisa Fátima Reginato Quevedo , Melo Rodrigo Henryque Reginato Quevedo
Published: December 2017

Atualmente, as discussões sobre sustentabilidade nas cidades apontam a arquitetura bioclimática como um viés fundamental no planejamento, no conforto ambiental e na qualidade de vida das populações nos centros urbanos. Neste trabalho, é realizado um estudo sobre o microclima existente no entorno da Praça Adolpho João Floriani, no bairro Vera Cruz em Passo Fundo, RS. Uma vez que a cidade é possui índices de construções elevado, é necessário a execução desta pesquisa para que através dos resultados, sejam encontradas alternativas que permitam o desenvolvimento da cidade sem comprometer o conforto ambiental e a qualidade de vida dos moradores. Desta forma, o presente artigo tem por objetivo identificar, analisar e verificar um dos fatores da ambiência urbana no espaço público, as ilhas de calor. Portanto, a realização do trabalho ocorre através de levantamentos de campo, onde foram medidas as temperaturas com equipamentos multiparametros, descritas as tipologias construtivas e descrito as características do uso do solo presente no entorno de cada ponto de coleta. Após a obtenção dos valores climáticos nas pesquisas de campo, os dados foram geoprocessados no Software ArcGIS, sobrepostos a imagens do Google Earth Pro e verificados em conjunto a um modelo 3D de análise da tipologia construtiva, possibilitando desta forma a comparação e análise das respostas a fim de justificar os resultados medidos. Assim, após discussão e debate, é verificado que as medições evidenciaram a existência de um microclima na região de estudo, apresentando indícios de que seu microclima é influenciado diretamente pela tipologia construtiva em seu entorno. Palavras-chave: ArcGIS, Microclima, Conforto Ambiental, Arquitetura Bioclimatica.
Revisitando um sonho moderno. O sistema de áreas verdes do Setor Sul em Goiânia: dos planos de Attílio Corrêa Lima e Armando de Godoy à atualidade
Authors: Caixeta Julia Lobo , Enokibara Marta
Published: December 2017

A capital de Goiás foi projetada por dois profissionais, o engenheiro-arquiteto e urbanista Attílio Corrêa Lima (1901-1943) e o engenheiro Armando Augusto de Godoy (1876- 1944). Attílio foi contratado em 1933 pelo Interventor de Goiás para a elaboração do Plano de Urbanização, demitindo-se da função em 1935. Godoy assumiu como consultor para a revisão dos projetos desenvolvidos anteriormente e elaborou um novo projeto para o Setor Sul, criando uma proposta de bairro-jardim com um sistema de áreas verdes públicas.  O Plano de Urbanização aprovado em 1938 previa que a cidade abrigaria 50 mil habitantes. Para 2017, o IGBE estimou uma população de 1.466.105 habitantes, aproximadamente 30 vezes mais que o previsto incialmente. Apesar do grande crescimento populacional, o Setor Sul manteve seu sistema de áreas verdes. Entretanto, ao longo dos anos, muitas dessas áreas encontravam-se subutilizadas e foram reurbanizadas através do Projeto CURA (1973). Mesmo assim, as áreas permaneceram em grande parte subutilizada ou foram invadidas e ocupadas por usos conflitantes. A pesquisa histórica evidenciou que apesar do grande potencial representado pelo sistema de áreas verdes do Setor Sul, projetos ou planos gerais não foram capazes de ativar o sistema originalmente proposto. Analisando a quadra F-40, adotada como estudo de caso no presente trabalho, detectou-se potencialidades, particularidades e problemas a serem resolvidos, concluindo-se que cada área deve ser estudada individualmente, observando as diferentes dinâmicas com seu entorno e a cidade.PALAVRAS-CHAVE: Espaços públicos. Sistema de áreas verdes. Goiânia.
Cidade dentro da cidade: Organização Espacial no Cemitério Vera Cruz, Passo Fundo RS
Authors: Carasek Mirian , Rampanelli Greice Barufaldi , Silva Maria Anita da
Published: December 2017

O objetivo deste estudo é avaliar a organização espacial do Cemitério Vera Cruz, em Passo Fundo/RS, para que sirva de base informativa para as propostas do Plano Diretor do cemitério, instrumento de planejamento já sugerido pela Prefeitura Municipal. Para tanto, o trabalho foi dividido em dois níveis de análise: macro e micro. A análise macro diz respeito à relação entre a cidade e o cemitério e o cemitério e seu entorno imediato. Assim, primeiramente, foram estabelecidas as relações de ocupação do espaço intermediário entre cidade e cemitério. Após, foram analisadas as vias e construções que o contornam, evidenciando a presença de um importante conjunto cemiterial.  A análise micro, por sua vez, direcionou-se à área específica do campo santo a abordagem levou a questões como a localização e condição dos acessos; a hierarquia das vias quanto ao fluxo e utilização efetiva; a análise dos lotes tumulares e dos ambientes de permanência, – existentes ou não. O Cemitério Vera Cruz apresenta algumas condições específicas, também abordadas no estudo, o caso do túmulo de Maria Elizabeth, que concentra visitantes e sobrecarrega o fluxo local. Junto disso, apresentam-se diversas tipologias tumulares, bem como sua tendência de verticalização. Complementarmente, o trabalho analisa as condições atuais de iluminação, segurança e higiene do cemitério, sob a ótica da promoção de visitas guiadas à toda população, no sentido de evidenciar a importância da preservação da história local. A metodologia adotada perpassa pela pesquisa historiográfica, visitas e levantamentos in loco, registro fotográfico, entrevistas e comparações com outros ambientes similares. PALAVRAS-CHAVE: Cemitério. Plano Diretor. Passo Fundo.
A paisagem cultural da cidade de Macapá: o rio comanda a vida.
Authors: Tostes José Alberto , Feijão Antônio da Justa , Moura Cássia Ingrid Rosa
Published: December 2017

O objetivo da pesquisa é analisar a relação das águas, rio/cidade e paisagem cultural em Macapá, no contexto da identidade com o patrimônio da Fortaleza de São José de Macapá e das influências do rio Amazonas na organização do espaço urbano da cidade. Para o desenvolvimento do estudo foi adotado o método histórico dialético com estudo qualitativo e elaboração de cartografias, a investigação foi desenvolvida pelo Grupo de Pesquisa Arquitetura e Urbanismo na Amazônia da Universidade Federal do Amapá. A importância do tema abordado reside na compreensão da relação rio/cidade e paisagem cultural como processos de interação que influenciam na organização do espaço urbano na região Amazônica, a exemplo de Macapá. Os resultados evidenciam que a interação entre águas, rio/cidade e paisagem cultural foi e ainda são fatores extremamente relevantes para a morfologia do lugar e por isso a conexão entre tais agentes não podem ser desconsiderados no planejamento de Macapá, bem como na sensibilização das práticas de preservação ambiental. PALAVRAS-CHAVE: Rio. Fortificações. Paisagem Cultural
Lichtenstein mesh hernioplasty: the extreme refinement in hernia surgery
Authors: M. Srinivas N. , M. Devaprashanth
Published: December 2017

Background: Inguinal hernia repair is the most commonly performed operation, owing to a significant lifetime incidence and variety of successful treatment modalities. The Lichtenstein tension-free repair has become the dominant method of inguinal hernia repair. The advantages of this repair were its association with less pain, rapid postoperative recovery, early return to normal activity and very low recurrence rate. We evaluated the treatment outcome of the tension free repair of inguinal hernias by the Lichtenstein mesh repair using polypropylene mesh.Methods: 200 patients treated for inguinal hernia with Lichtenstein mesh hernioplasty between May 2015 to April 2016 were reviewed. Data recorded included age, sex, symptoms, site of hernia, unilateral or bilateral hernia, postoperative complications, and recurrence in follow up period of one year.Results: 55% patients had indirect and 41% had direct inguinal hernia while 4% had pantaloon hernia. Seroma occurred in 2% patients and hematoma in 6%. Superficial surgical site infection was seen in 3% patients. Transient testicular swelling was noticed in 7% patients.Conclusions: Lichtenstein tension-free mesh hernioplasty is simple, safe, effective and economical and has good patient satisfaction and low recurrence rate.
SYNTHESIS OF 6-{4-AMINO-N-[2-(DIETHYLAMINO)ETHYL]-O-ANISAMIDO-5- YL}-AMINO-2-THIO-3-SUBSTITUTEDAMINO,4-SUBSTITUTEDIMINO-1,3,5- THIADIZINES
Authors: R. D. Thombare D.T.Tayade , , Waghmare S.A.
Published: December 2017

Recently a novel series of 6-{4-amino-N-[2-(diethylamino)ethyl]-o-anisamido-5-yl}amino-2-substitutedimino-3- substituted-4-thio-1,3,5-thiadizines was successfully synthesized by the isomerisation of 4-{4-amino-N-[2- (diethylamino)ethyl]-o-anisamido-5-yl}-amino-2,6-disubstitutedimino-1,3,5-dithiazines by 5% aqueous sodiumbicarbonate in ethanol medium. The structures of all synthesized compounds were justified on the basis of chemical characteristics, elemental analysis and spectral studies.
Up-To-Date Approach To Monitor Pancreatic Exocrine Insufficiency In Adult Patients With Cystic Fibrosis.
Authors: Slavova Mila Kovacheva- , Siminkovitch Sylvie , Gecov Plamen , Genov Jordan , Golemanov Branimir , Mitova Rumyana , Vladimirov Borislav
Published: December 2017

Cystic fibrosis (CF) is a rare multi-system autosomal-recessive genetic disease. Pancreatic exocrine deficiency (PEI) develops in 85-90% of patients. Proper monitoring of ongoing PEI treatment prevents the development of complications - cardiovascular events, osteoporosis, poor quality of life. In this case of a 32-year-old patient with advanced PEI, we demonstrate the modern approach to monitor patients in adulthood.
Perjudian Online: Kajian Pidana atas Putusan Nomor 1033/PID.B/2014/PN.BDG
Authors: Falah Muhammad Fajrul , Tanuwijaya Fanny , Samosir Samuel SM
Published: December 2017

Law Number 11 / 2008 on Information and Electronic Transaction (UU ITE) is the regulation concerning on criminal law in addition to the Criminal Code (KUHP). UU ITE is commonly regarded additional regulation of the Criminal Code as a special law (lex specialis) in which Penal Code is deemed as lex generalis. It is based on the principle of lex specialis derogate legi generalis. This article uses legal research to review the decision of District Court in Bandung Number 1033/PID.B/2014/PN.BDG where it comprises legislation and cases. It concludes that the judge is not frugal in applying the principle lex specialis derogat legi generalis in the consideration. This is associated with the indictment of public prosecutor which only prejudges with article 303 paragraph (1) to 2. In contrast, the indictment which does not meet the requirement of a careful, clear, and complete description asserts to become void by law.

Keywords: Online Gambling, Criminal Principle, Indictment
Implementasi Pengelolaan Sumber Daya Laut Nasional Terhadap Kebijakan Pemerintah Provinsi Kepulauan Riau
Authors: Mirza Ahmad Chaidir , Anggraini R.A. Rini , Soetijono Iwan Rachmad
Published: December 2017

Riau Islands Province is an island-based region consisting of a group of islands. The Province has a very strategic geographic location due to bordering the neighboring countries in Southeast Asia, viz. Singapore, Brunei Darussalam, Malaysia, Cambodia, and Vietnam. It is different from other Island-based provinces, in which it lies in the hub areas of Malacca Strait. It shows that the Province is an important location to trade from America, Europe and Asia, in addition to a plenty of marine resources that will potentially maximize local government’s revenue and prosper society in the province. However, such marine resource has not been well-managed by local government by which in 2013 the figure shows poverty rate remains high. The decline of poverty rate counts only in urban areas where they do not lie in submarine areas, but the poverty has increased and could not be well-resolved. It asserts that the Government of Riau Islands has not maximized local powers to resolve poverty problems in the region.

Keywords: Policy, Local Government, National Marine Resources
Pengelolaan Barang Milik Daerah Berdasarkan Peraturan Pemerintah Nomor 27 Tahun 2014 tentang Pengelolaan Barang Milik Negara/Daerah
Authors: Febriana Era Nandya , Jayus Jayus , Indrayati Rosita
Published: December 2017

Indonesia is the Unitary State. It is understood that within a unitary state, the central government operates a high state sovereignty. In order not to be arbitrary, the activities of the central government are supervised and limited by the constitution. The government which is divided from the Central Government to the Regional Government included Regional Autonomy therein, as well as the authority of the Regional Government, is on duty to manage the Regional Property. In carrying out its authority as an administrator of local property, there are still many abuses or omissions committed by the local government in operating its authority in managing regional property, such as the negligence of the Regional Assets, the misuse of authority in the revocation of rights already granted by the regional government on the right to use of local property, using local property for personal interest. In the management of regional property required planning, implementation, and supervision by the local government in accordance with applicable laws and regulations in the constitution.

Keywords: Authority, Local Government, Management of Regional Property
Kepemilikan Saham oleh Buruh sebagai Upaya Penegakan Sistem Ekonomi Pancasila
Authors: Wahyudi Epri
Published: December 2017

This article discusses the conceptual idea in addressing the situation of workers in Indonesia who are perceived not to have the right to prosper in the work already owned. In economics, labours play an important role because they are the wheels in driving the production of goods and services. The unfilled labour rights to live prosperous is caused by the absence of their authority to contribute in determining a policy within a company. To overcome the imbalance of bargaining position between workers and employers, a regulation or policy is required to materialise access to share ownership within the company. By owning shares, workers have the right to convey ideas in determining company policy. In addition, labours will also easily access all company information including company report approval. It concludes that the ownership of shares by labours in the company is a necessity and an effort to realise Pancasila Economic System in order to fulfil the more substantive labour rights.

Keywords: Share Ownership, Labours, Pancasila Economic System
Agama, Pancasila dan Konflik Sosial di Indonesia
Authors: Fauzi Agus
Published: December 2017

During Reformasi Era, Indonesia has still had serious social issues with reference to social clashes and religious violence. The contestation between majority and minority and the monopoly of interpretation of Pancasila as a state ideology have dominated public sphere which affects on the increase of social clash with various backgrounds. The increase of social clash including religious violence results in the uncertainty whether or not Pancasila as a state ideology is capable of tackling contemporary Indonesian realities. Moreover, Pancasila also needs to tackle religious transnationalism ideology which has spread across the nation and receive positive sympathy from some Indonesians. Based on these realities, this writing aims to examine dimension of divinity and humanism in Pancasila and then propose an ideal concept of the divinity in the framework of Indonesian unity.

Keywords: Pancasila, Religious Conflict, Indonesia and Ideology
Materiais didáticos e a educação física escolar
Authors: Tahara Alexander Klein , Darido Suraya Cristina , Bahia Cristiano de Sant'nna
Published: December 2017

Os materiais didáticos são instrumentos que podem auxiliar o professor no processo de ensino e os alunos na aprendizagem sobre os conteúdos curriculares. O objetivo deste estudo foi discutir sobre a relação entre os materiais didáticos e a Educação Física escolar, apresentando trabalhos que refletem e argumentam a respeito desta relação, inclusive em alguns deles inserindo-se as tecnologias no desenvolvimento dos materiais. Espera-se que a produção dos materiais didáticos possa ser maior na Educação Física escolar para que o professor tenha mais recursos para ministrar os conteúdos curriculares nas aulas.
QUEM DISSE BERENICE, QUE SER GAY É SER UM BOM VENDEDOR DE LOJAS DE SHOPPING?
Authors: Santos Natacha Secco , Silva Luis Fernando Moreira , Cassandre Marcio Pascoal
Published: December 2017

Este trabalho tem como intuito compreender o padrão normativo da contratação de gays em lojas de shopping. Para isso, a contratação na percepção contratantes e dos contratados gays é analisada a partir das categorias de análise: físico, cognitivo, material, representacional e seus atributos em comum na contratação de funcionários gays. Foram entrevistados cinco contratantes e seis contratados de lojas de um shopping de Maringá. Os resultados encontrados mostram que, contratantes são instruídos e enxergam a necessidade de contratar vendedores gays, mas priorizam pelo perfil heteronormativo. Conclui-se que existe discriminação na contratação de gays e um padrão comportamental exigido pelas organizações.
A GESTÃO DE PESSOAS E O RELACIONAMENTO INTERPESSOAL NO COOPERATIVISMO
Authors: Carvalho Adriano Dias de , Silva Bianca Alves dos Reis
Published: December 2017

A cooperativa é uma organização dinâmica, constituída por uma rede de relações entre os próprios indivíduos e com o trabalho em si. Para tal, a Gestão de Pessoas apresenta-se como uma alternativa a esta para gerenciar da melhor forma os relacionamentos existentes nessa organização. O presente artigo buscou analisar a abrangência desta área em uma Cooperativa da cidade de Mococa, focando o relacionamento existente entre funcionários. Desenvolveu-se um estudo de caso de característica qualitativo, utilizando a prática da entrevista como meio e obtenção de dados. Com os resultados obtidos e analisados foi possível verificar o reconhecimento da importância dos funcionários e como seus relacionamentos podem interferir no desenvolvimento organizacional, considerando os aspectos do trabalho em conjunto formulado por essa teia de relações e práticas auxiliadoras oferecidas pelos princípios dos recursos humanos. Mediante estas concepções, compreende-se a Gestão de Pessoas assimilada a uma ferramenta de gerencia as vastas relações existentes na cooperativa, a fim de que a organização utilize seu capital intelectual da melhor forma, gerando benefícios para ambos.
IDENTIFIKASI DAN KARAKTERISASI 11 KULTIVAR TANAMAN TOMAT SEBAGAI SUMBER GENETIK UNTUK PERSILANGAN
Authors: Qonit Muhammad Abdillah Hasan , - Kusumiyati , Mubarok Syariful
Published: December 2017

Salah satu jenis tanaman hortikultura penting yang banyak dikembangkan di Indonesia adalah tanamantomat (Lycopersicum esculentum Mill). Beberapa cara dapat dilakukan untuk meningkatkan produksi dan kualitastanaman yang salah satunya adalah dengan mendapatkan varietas unggul baru. Pada tahapan ini maka perludiseleksi terlebih dahulu jenis tomat yang mempunyai hasil baik dan toleran terhadap gangguan organismepenggangu tanaman (OPT). Tujuan penelitian ini adalah untuk mendapatkan kultivar tomat yang baik dari segipertumbuhan yang dapat dijadikan sebagai sumber genetik untuk bahan persilangan. Dalam percobaan inidilakukan identifikasi dan karakterisasi 11 kultivar tomat hasil introduksi yang terdiri dari A: ‘Oxheart’; B:‘Moskvich’; C: ‘Valencia’; D: ‘Marmande’; E: ‘Moneymaker’; F: ‘La Sweetie’; G: ‘Principle Borghese’; H:‘Golden Sunrise’; I: ‘Red Cherry’; J: ‘Black Cherry’; dan K: ‘Golden Jubille’. Hasil pengamatanam menunjukkanbahwa setiap kultivar tomat introduksi mempunyai respon pertumbuhan yang berbeda. Tomat ‘Black Cherry’menunjukan respon pertumbuhan yang terbaik dengan pertimbangan tinggi tanaman, tinggi tandan pertama,diameter batang tanaman, jumlah bunga per tandan, dan jumlah buah per tandan.Serta mempunyai ketahananterhadap serangan organisme pengganggu.Kata kunci: introduksi, pertumbuhan, tomatABSTRACTOne of the important horticultural crops in Indonensia is Tomato (Lycopersicum esculentum Mill.). Severalmethods can be used to improve productivity and quality of tomato such as by generating new tomato cultivar withdesired characters. To generate new cultivars therefore new selection in parental tomato is needed to get thepotential parental tomato as genetic background. The purpose of this study was to find out the potential tomatocultivars such as high productivity and quality, adaptive grown in Indonesia and also resistant to pest and disease.Eleven tomato cultivars introduction was used in this experiment consisted of A: 'Oxheart'; B: 'Moskvich'; C:'Valencia'; D: 'Marmande'; E: 'Moneymaker'; F: 'La Sweetie'; G: 'Principle Borghese'; H: 'Golden Sunrise'; I:'Red Cherry'; J: 'Black Cherry'; and K: 'Golden Jubille'. The results showed that each introduced tomato cultivarhas a different response to environmental condition. Tomato ‘Black Cherry’ showed the best plant growthcompared to other cultivars. It had the highest plant height; shoot diameter, no of flower per truss, and no of fruitper truss. It also showed as a resistant cultivar to the pest and disease.Keywords: introduction, plant growth, tomato
Quando as Parcerias Vencem o Medo e Compartilham Exitos Projeto Piloto com as Unidades Móveis no Território Rural Serra Catarinense
Authors: Pires Santos Julio César , Camargo José Rodolfo , Aparecida Camargo Erli
Published: December 2017

O presente artigo tem o propósito de compartilhar uma experiência exitosa que ocorreu no Território Rural Serra Catarinense, contextualizando-a geográfica e politicamente; identificando o cenário, que forças vivas nela atuaram para a sua concretização, e sob que circunstancias foi realizada. Cuida, por necessário, de caracterizar as relações de gênero vigentes ainda no território,o qual é marcado por machismo, sexismo, misoginia com consequentes violências contra a mulhere precário exercício de cidadania, principais fatoresa justificar o esforço solidário assumido para com todos os demais municípios do Estado, os quais, sem esse trabalho, por certo deixariam de usufruir das unidades móveis (batizadas como “onibas” lilás), doadas pelo governo da Presidenta Dilma Rousseff a Santa Catarina, em dezembro de 2013, e que seriam devolvidas sem uso ao governo federal, em julho de 2016. Assim, a experiência aqui sistematizada, cumpre a missão de fazer saber às(aos) interessadas(os), que quando há vontade política, engajamento e trabalho conjunto entre os poderes públicos e a sociedade civil, por mais difícil que seja o desafio, este será superado e, quem sabe até imitado. É a experiencia, um marco na história de SC, eestando pautada nas diretrizes do Pacto Nacional de Enfrentamento à Violência Contra a Mulher, e no ProgramaMulher, Viver sem violência,fornece subsídios teóricos e práticos para a elaboração de políticas voltadas ao tema, merecendo, pois, atenção por parte de gestores esociedade civil, seja para entender os contextos geradores das mais variadas violências contra a mulher,ou para elaborar diagnósticos situacionais e planos locais de enfrentamento a esse problema de saúde pública grave e alarmante. Está a abordagem, divididaem três momentos: o cenário territorial, a execução do projeto piloto como experiência pioneira em SC, e o que ficou de frutos para o futuro: desafios ainda presentes e lições aprendidas com o trabalho realizado em parceria.
Sobre la felicidad. Estudio filosófico-jurídico y de derecho comparado
Authors: Lorca Martín de Villodres María Isabel
Published: December 2017

La importancia de la felicidad y su oportuna vinculación con la justicia han sido puestas de manifiesto desde el pensamiento filosófico clásico griego. Sin embargo, recientemente puede apreciarse claramente el creciente protagonismo y la inusitada actualidad que ha alcanzado el tema de la búsqueda de la felicidad en el discurso político, lo que obliga a meditar sobre ella como principio rector o directriz orientadora del Estado Social, y a saber detectar su presencia — explícita o implícita— en los textos constitucionales. Solo en una sociedad democrática, y desde el desarrollo efectivo de los derechos fundamentales y de los derechos sociales, particularmente, será posible alcanzar una vida digna, y a partir de ahí obtener el basamento adecuado para la búsqueda de la felicidad. La felicidad, pues, no es solo un objetivo individual, es también un asunto público que ha de venir propiciado desde el propio Estado, en cuanto que desde los poderes públicos pueden establecerse las bases adecuadas para su consecución. En la CE de 1978 podemos encontrar preceptos para entender implícitamente incluida la felicidad como directriz orientadora del Estado en sus políticas públicas, y poder sostener así la presencia de una teoría eudemonista en nuestro Estado social. Percibir la existencia de una notable preocupación por la felicidad de los ciudadanos en el desarrollo de las políticas públicas actuales supone, en cualquier caso, un afortunado retorno hacia el ámbito de lo humano, una nueva oportunidad para preocuparnos por el ser persona.
Patria potestad en los procesos de autorización de viaje de menor
Authors: Shinno Pereyra Vanessa Elizabeth
Published: December 2017

El presente trabajo centra sus objetivos en establecer si existe una pérdida de la patria potestad en los procesos de autorización de viaje de menor, debido a que el niño, niña o adolescente reside en otro país y no tiene contacto directo con uno de sus padres.