bluuebunny/crossref_metadata_2025 huggingface dataset:
Afrykańczycy na wojennej ścieżce. Społeczne, kulturowe oraz komunikacyjne spory pogan i chrześcijan w III wieku n.e., na przykładzie „Oktawiusza” Minucjusza Feliksa
Authors: Jastrzębski Bartosz
Published: December 2021

Celem niniejszego artykułu było ukazanie konfliktu między chrześcijanami a poganami w czasie, gdy chrześcijaństwo pozostawało religią nielegalną (połowa III wieku n.e.). Konflikt ten w znacznej mierze miał podłoże w niemożności uzgodnienia różnych sposobów komunikowania odrębnych, wzajemnie nieuzgadnialnych wizji świata. Komunikacyjna zapora wynikała też z negatywnego wizerunku chrześcijan, swoistego „czarnego PR”, opierającego się na sensacyjnych plotkach, powstających w środowiskach miejskich Cesarstwa Rzymskiego. Jednym z ważniejszych zarzutów stawianych chrześcijanom było oskarżenie o demontowanie porządków: prawnego, kulturowego i społecznego (aspołeczność, sekciarstwo, niezrozumiała obyczajowość wewnątrzgrupowa). Niniejszy artykuł stawia sobie za zadanie szczegółową analizę owych zarzutów i obrony chrześcijaństwa, dokonywanej przez chrześcijańskich konwertytów, pochodzących z rodzin pogańskich.
Análisis de los materiales de información a la ciudadanía de la campaña del Ministerio de Sanidad “Este virus lo paramos unidos” publicados entre marzo y mayo de 2020
Authors: Huertas Ciórraga Elisa
Published: December 2021

Introducción: La comunicación sanitaria puede proteger la salud y la calidad de vida individuales. Durante las crisis sanitarias deben adaptarse los mensajes a la población. Objetivo: Analizar los materiales de la campaña del Ministerio de Sanidad Este virus lo paramos unidos. Metodología: Se recopilaron todos los materiales de dicha campaña destinados a población general publicados en los meses de marzo, abril y mayo en la Web del Ministerio de Sanidad. Posteriormente se establecieron dos análisis: la forma de presentar el mensaje y el tipo de información que contenían. Resultados: La mayoría de los mensajes son correctos, rigurosos, claros y de fácil comprensión según criterios como la longitud del mensaje. También presentan fecha de publicación y apoyo visual. Sin embargo, deberían incluirse más fuentes de información. Conclusiones: El análisis ha sido positivo en cuanto al contenido, la exactitud, la claridad y la longitud de los mensajes, y en cuanto a la presencia de fechas de publicación y apoyo visual. El tipo de contenido mayoritario es la prevención de contagios.
A mediatização da Covid-19 em Portugal: os primeiros meses da pandemia nos jornais online
Authors: Gomes Emiliana Sofia Coelho
Published: December 2021

Introdução: No final de 2019, deu-se início a uma crise de Saúde Pública com o surgimento do novo Coronavírus. Em poucos meses este vírus atingiu praticamente todos os países do mundo e, em Portugal, os primeiros casos foram registados em março de 2020. Objetivo: Perceber de que modo o Jornalismo online português mediatiza a COVID-19. Metodologia: Foram analisados os artigos noticiosos sobre COVID-19 publicados em quatro edições online: Jornal de Notícias, Público, Observador e Notícias ao Minuto. Resultados: Os 280 artigos apontam para um forte recurso a novas plataformas como as redes sociais e as versões móveis dos jornais, assim como se distingue a apresentação de números, a identificação de formas de prevenir a doença e a explicação sobre o processo de transmissão do vírus. Estas notícias são divulgadas maioritariamente, com foco nacional e com recurso a várias formas imagéticas. Evidencia-se, ainda, a assídua presenta de fontes de informação e o reduzido número de fontes por artigo. Conclusões: A crise gerada pela COVID-19 veio consolidar o uso de plataformas digitais que fomentaram um sistema mediático híbrido, em que coexistiram novos e antigos meios de comunicação, assim como trouxe novas formas de comunicação e novos desafios, equacionando-se as potencialidades do Jornalismo.
The phenomenon of bubu tradition in the cycle of time: Portrait of reciprocity in rural Madura
Authors: Rizqiyah Halimatur , Warsono Warsono , Jacky M. , Nasution Nasution
Published: December 2021

Bubu is a form of reciprocity that occurs in Madura generally and Langkap Village particularly. Generally, the exchange is made by the community as a form of “donations” to the celebration host. The host hopes for a return in the future. The reciprocal incident that occurred in Madura was not just a hope but more of an “obligation” to pay the “donation” or bubu that had been given on the previous occasion. This study seeks to describe the form and meaning of the bubu as well as to explain the changes that occur in the bubu phenomenon which used to be only in the form of voluntary donations into various forms of bubu with their meanings. The research design used was an ethnographic study with a moderate method where the researcher was occasionally directly involved in the tradition. The results of this study reveal several forms of bubu that occur in Langkap Village with different ways and meanings with the same motivation. The bubu given is a transaction of accounts payable and investment with the hope of a return in the future. More than that, there are social sanctions that will await if the bubu that have been given are not returned with the same value.
Commodification of The Mangalahat Horbo Bius Ritual on The Samosir Island North Sumatra: A Controversial Show
Authors: Siregar Mangihut
Published: December 2021

The mangalahat horbo bius ritual is a Batak tradition to offer the best sacrifice to God called Mulajadi na Bolon. This tradition is carried out since they still adhere to the parbaringin flow. The entry of Dutch colonialism into Tapanuli resulted in this tradition being a forbidden tradition. In 2008, the government of Samosir Regency raised this tradition as a show of its purpose as a tourist attraction. Since it was made into a show, there were pros and cons in the community. To explore this attitude research needs to be done. This study uses a qualitative method. The researcher chose the informant purposively followed by the snowball technique. Selected informants: government, religious leaders, and traditional leaders. Data analysis was carried out from the time the study began until the inductive analytic descriptive research results. Theories used as analysis: the theory of power/ knowledge discourse, postcolonial theory, commodification theory, and social practice theory. The theory is used eclectically. The results showed that this ritual performance was counterproductive in increasing the number of visits.
A DIACHRONIC STUDY OF THE AUTHORIAL IDENTITY IN TOURISM RESEARCH ARTICLES
Authors: Praminatih Gusti Ayu
Published: December 2021

The use of first-person pronouns (I, we) in writing research articles was remaining problematic for both inexperienced and advanced authors. Nevertheless, some research suggested that the FPPs were increasingly used in writing research articles (RAs) to indicate the authorial identity. This research aimed to investigate types, functions, and correlation of the FPPs in tourism RAs by employing the diachronic corpus linguistics method. The data of this research were accessed and downloaded through five open access journals published by Elsevier. There were 80 selected tourism RAs from the year 2015 to 2020 that classified into five corpora. AntConc was software that was employed to retrieve the FPPs from the corpora. This research discovered the FPPs I and we were constructed as six types of authorial identity that range from the least to the strongest authoritative identity in the past five years. The constructed authorial identity had three main functions for the authors of tourism RAs, tourism as an academic discipline, and the readers of tourism RAs. The statistical calculation showed that the correlation was 0.87 that signified the use of the FPPs was increasing in the following year.  Keywords: authorial identity, diachronic corpus linguistics, the first-person pronouns, tourism research articles.
Institutional Racism and Black Resistance as Portrayed through Images and Narratives in American Graphic Novels
Authors: Soelistyarini Titien Diah , Rinahayu Nuril , Nuswantari Ridha Dinauri
Published: December 2021

For centuries, racial discrimination and injustice have resulted in the struggle of African Americans to resist racial inequality. Nevertheless, their struggle has never been easy since racism against African Americans has long been institutionalized. In other words, any kinds of white oppression that marginalized, discriminated, and alienated African Americans have embedded in formal institutions, such as legal, educational, as well as social and political institutions. Accordingly, this study dealt with institutional racism and black resistance in the United States as portrayed through images and narratives in two American graphic novels, Octavia E. Butler’s Kindred: A Graphic Novel Adaptation and John Lewis’ March: Book Three, which depicted different ways African Americans were oppressed by and resisted against institutionalized racism. This study applied African American criticism to reveal the racism and black resistance portrayed in both graphic novels based on Feagin’s and Better’s theories of systemic racism and institutional racism. As this study focused on graphic novels, the analysis combined both narrative and non-narrative elements in making meaning through cues provided in the graphic novels, including stressed words and facial expressions. This study reveals that the whites have successfully oppressed African Americans for so long due to the white racial frame and its embedded racist ideology that enforced segregation system. Furthermore, the findings suggest that only by empowering themselves, African Americans are able to resist institutionalized racism in order to gain their freedom and equality of rights.
A versatile messenger for chirality communication: asymmetric silica framework
Authors: Liu Xinling , Jin Ren-Hua
Published: December 2021

Asymmetric tetrahedral carbon is the basic structural unit of many organic compounds in life and its molecular chirality plays a key role in regulating biological functions. Silica (SiO2) is highly earth abundant and its basic unit is also the tetrahedral form of SiO4. However, much less attention has been paid to the molecular-scale chirality of SiO2 frameworks with repeating SiO4 units because it is challenging to enantioselectively control the molecular structures of SiO2. Research into the chiral molecular structures of SiO2 deserves to be a significant topic for understanding widespread chiral phenomena and for exploring the chiral properties hidden in inorganic matter. This review highlights the asymmetric synthesis strategies that endow SiO2 with chirality transferred from asymmetric carbon at the molecular scale. The chirality transfer ability of SiO2 is also demonstrated for the construction of various inorganic and/or organic chiral materials with a wide range of applications in asymmetric synthesis, circularly polarized luminescence and Raman scattering-based chiral recognition.
Підвищення ефективності обробки потокового відео за допомогою використання безсерверних технологій
Authors: Ахаладзе I. , Лісовиченко O.
Published: December 2021

В даній статті проведено аналіз підходів для вирішення задачі аналізу вхідного відео потоку в режимі реального часу. Розглянуто архітектури для побудови системи обробки відео потоку в якій функціонують більше одного джерелавідеопотоку, що передають дані одночасно в режимі реального часу для вирішення задачі покадрового розпізнавання, та запропоновано рішення з урахуванням умов динамічної зміни кількості джерел, обробка в реальному часі, ізольованість відео потоку кожного окремого джерела. Розглянуто реалізацію із статично виділеними ресурсами, а також запропонована безсерверна архітектура що вирішує виявленні дедоліки. Швидкодія та модульність запропонованої архітектури вирішує виявлені недоліки архітектури з статтично виділеними ресурсами, а також дає можливість зменшити час простою обчислювальних потужностей, шляхом автоматичного швидкого динамічноговидалення ресурсів, що не використовуються в конкретний момент часу або додавання додаткових ресурсів при підвищенні навантаження.

Бібл. 3, іл. 3.
Технологія створення ботів для широкого класу застосувань на основі логічного підходу
Authors: Вовк Є.
Published: December 2021

Об’єктом дослідження є інформаційна технологія автоматизованого створення ботів на основі логічного підходу. Мета є розробка загального підходу до створення ботів з використанням комплексу логічних і лінгвістичних моделей та роз-роблення загальної схеми роботи web-орієнтованої системи з використанням чат-боту. Наведено модель логіки дій і описаний метод виведення, які можуть бути використані для формального описання процесу створення ботів. Описаний приклад використання логічної моделі для створення бота.

Бібл. 6, іл. 4.
Можливості платформи Sikorsky distance для реалізації дистанційного і змішаного режимів навчання
Authors: Тищенко М. , Сергеєва О.
Published: December 2021

Об'єктом даного дослідження є аналіз відношення викладачів і студентів до дистанційного і змішаного режимів навчання, а також специфіка використання таких режимів навчання в сучасних реаліях. У статті використовувалися порівняльний і пошуковий види дослідження. У дослідженні взяли участь 37 студентів Національного технічного університету України «КПІ ім. Ігоря Сікорського». Студенти брали участь в дослідженні на добровільних засадах в 2020-2021 роках. Для збору даних використовувалася анонімна анкета. Опитування студентів показало, що більшості з них подобається ідея використання змішаного режиму навчання. Метою дослідження є аналіз сучасного стану реалізації дистанційного і змішаного режимів навчання та спроба надати 31 параметр підбору інструментів для подальшого використання українськими та закордонними педагогами з метою реалізації дистанційного і змішаного режимів навчання. Реалізація дистанційного і змішаного підходів описана з акцентом на студентів, які вивчають інформаційні технології. Був зроблений висновок, що використання платформи Sikorsky distance, з акцентом на потреби учнів, допомагає урізноманітнити навчання в технічному університеті та сприяє розвитку професійних навичок.

Бібл. 12, табл. 1.
Вплив технологічних режимів обробки латунної основи на якість форм інтагліодруку
Authors: Киричок Тетяна Юріївна , Талімонова Надія Леонідівна , Клименко Тетяна Євгенівна , Баглай Володимир Анатолійович , Руденко Едуард Михайлович , Талімонов Ярослав Юрійович , Новицька Анна Євгенівна
Published: December 2021

Досліджено вплив параметрів та технологічних режимів обробки латуні на якість її поверхні та адгезію захисного покриття для виготовлення форм інтагліодруку методом прямого лазерного гравіювання.
Для проведення досліджень було використано модельну латунну форму (латунь марки Л63), яку було запроектовано і виготовлено фахівцями Банкнотно-монетного двору Національного банку України із застосуванням системи прямого лазерного гравіювання Jura JSP Direct Laser Engraver.
Мікроскопічні дослідження зразків дозволили виявити, що у результаті обробки поверхні пластини плазмою геліконного розряду спостерігаються зміни як зовнішнього виду поверхні, так і її елементарного складу. В результаті аналізу елементарного складу поверхні виявлено, що збільшення часу обробки призводило до збільшення на поверхні частки Cu з одночасним зменшенням Zn і O.
Зокрема, дослідження адгезії модельного покриття нітрид алюмінію дозволило виявити, що найвищий рівень адгезії спостерігається на поверхні латуні, що піддавалася обробці протягом 45 хв, а найменший — на необробленій поверхні. Відрив тестового елементу на необробленому зразку відбувся при зусиллі 2,2 МПа, на зразку, що піддавався обробці протягом 10 хв — 8 МПа, на зразку, що піддавався обробці протягом 45 хв — 9,8 МПа.
Аналізуючи отримані результати можна дійти висновку, що у зразків, які оброблялись в плазмі геліконного розряду, показник адгезії збільшився, і це говорить про те, що обробка латуні є доцільною задля покращення в подальшому адгезії із захисним покриттям.
Фактори впливу на якість тампонного друку на полімерних основах
Authors: Киричок Петро Олексійович , Чепурна Катерина Олександрівна , Коробка Максим Володимирович , Назаренко Олена Володимирівна
Published: December 2021

В роботі визначено ключові чинники впливу на якісні показники відбитків у тампонному друці, а саме устаткування, матеріали та експлуатаційні. Встановлено, що для забезпечення оптимального співвідношення якість—продуктивність виготовлення продукції, найбільш впливовими є експлуатаційні фактори, а саме параметр швидкості друку. Швидкість друку діє комплексно, так як безпосередньо впливає на продуктивність виготовлення продукції та опосередковано якісні показники відбитків, а саме графічну точність відтворення штрихових елементів. Встановлено, що оптимальна робоча швидкість друку складає 600–700 цикл./год, що дозволяє отримати продукцію з мінімальними графічними спотвореннями. Експериментально встановлено, що збільшення швидкості призводить до виникнення на відбитках значних фарбових ниток, які візуально знижують різкість сприйняття зображення.
Nanoheteroepitaxial structures with quantum dots obtained by liquid-phase epitaxy based on GaP
Authors: Bondarec S.V. , Bykovskij S.YU. , Maronchuk I.E. , Maronchuk I.I. , Petrash A.N. , Smirnov S.B. , Sanikovich D.D.
Published: December 2021

A method of an obtaining of nanoheterostructures with arrays of quantum dots by a process of liquid phase epitaxy with a pulse cooling and a heating of substrate are described. Experimental results for a growing of heterostructures on a base of GaP with quantum dots Ge, InAs and for an investigation of parameters by the atomic-power microscopy and photoluminescence are presented.
Cluster model of the formation of aluminum nitride in alumina nanoreactors
Authors: Hlotov V.Y. , Deminskij P.V. , Lyahova N.O. , Masol I.V. , Osinskij V.I.
Published: December 2021

The non-traditional method of obtainingclusters of heterogenous and homogenous nanooxides, nitrides of aluminum by substitution ofoxygen atoms with low-energy nitrogen ions inthe solid phase inside the nanopores of aluminum oxide Al2O3 (nanosapfire) is proposed and implemented. The AlN, AlNxO1-x, Al2O3 nanolayers was experimentally obtained
Impedance inverters in LC harmonic generators hesitation
Authors: Zubar V.P. , Bodnya T.V. , CHajkovskij A.S.
Published: December 2021

Applications of negators of impedance (IN) are considered on an operating strengthener (OS), strengtheners on bipolar and field transistors in the LC-generators of harmonic vibrations. By the immitans criterion of stability the algorithm of analysis of LC-generators is resulted, analytical expressions, necessary for the calculation of primary parameters of generator, are got
Application of generalized spectral transform in oriented basis in CDMA systems
Authors: Lazarev D.V. , Tereshchenko T.A.
Published: December 2021

The paper shows advantages of the general ized transform in an oriented basis (OB) for CDMA systems. The possible number of chan nels for the proposed transform conversion is determined. A comparison with known Walsh functions based and OB functions based CDMA systems is made. The performance comparison of proposed and known systems is estimated
Dynamics of processes in a high-voltage power supply, operating on technological load
Authors: Rudenko T.V. , Rudenko YU.V.
Published: December 2021

The analysis of output voltage ripples in dependence of the internal parameters of power transformer is provided. The dynamics of processes at the output circuits of power supply is analyzed with taking into account the particularities of its operation on the technological
ОГЛЯД СУЧАСНИХ ТЕХНОЛОГІЙ ДЛЯ ДІАГНОСТИКИ ЯКОСТІ СНУ
Authors: Іванова Я.О. , Федорін І.В. , Вдовиченко О.В.
Published: December 2021

Реферат – Сон - це складний психофізіологічний стан, який безпосередньо визначає психічну і біологічну активність людини. Важливість сну обумовлена в першу чергу його необхідністю для організму. Сон – унікальний механізм відновлення та адаптації до умов життя. Одна безсонна ніч знижує стійкість імунітету до інфекційних захворювань і швидкість реакції на зовнішні імпульси. У віддаленій перспективі постійний дефіцит і зниження якості сну підвищують ризик розвитку серцево-судинних і ендокринних захворювань. Золотий стандарт об'єктивної оцінки сну, полісомнографія, зазвичай виконується в лабораторії сну, і дані вручну оцінюються фахівцем зі сну, що робить цей процес незручним, дорогим і менш придатним для довготривалих досліджень. Тому існує потреба в перевіреному недорогому обладнанні для оцінки сну, яке було б зручним і точним. З клінічної та дослідницької точки зору можливість отримання даних про безсоння, може персоналізувати рішення про лікування та оптимізацію здоров'я, а також поліпшити фенотипування захворювання. Мета даної статті – дослідження сучасних методів аналізу якості сну, визначення їх переваг та недоліків, та пошук альтернативних засобів для моніторингу сну. В роботі наведені результати порівняльного аналізу технологій для відстеження сну, а також запропоновано альтернативу полісомнографії, яка може використовуватися для надійного та довгострокового моніторингу. Зокрема, проаналізовані роботи, що вивчали застосування біорадара як засобу аналізу фізіологічного стану людини. Біорадар - це новий вид радіолокатора, що поєднує технології біомедичної інженерії та радіолокації. Його ціль – безконтактне виявлення життєво важливих ознак через неметалеві перешкоди, такі як одяг та стіни, передаючи спеціальну електромагнітну хвилю. Дана технологія може стати кроком вперед в індустрії відстеження сну.Ключові слова: полісомнографія, моніторинг сну, актиграфія, дистанційний моніторинг, біорадари.
ONE APPROACH TO ACCELERATE THE EXPONENTIATION ON GALOIS FIELDS FOR DATA PROTECTION CRYPTOGRAPHIC SYSTEMS
Authors: Markovskiy Aleksandr , Rusanova Olga , Ghassan Abdel Jalil Halil Al-Mrayat , Kot Olga
Published: December 2021

The new approach to accelerate the computational implementation of the basic for a wide range of cryptographic data protection mechanisms operation of exponentiation on Galois Fields have been proposed. The approach is based on the use of a specific property of a polynomial square and the Montgomery reduction.  A new method of squaring reduces the amount of computation by 25% compared to the known ones. Based on the developed method, the exponentiation on Galois Fields procedure has been modified, which allows to reduce the amount of calculations by 20%.
Comparison of Infrared Thermal Imaging with Two Canine Pain Assessment Tools in Dogs Undergoing Treatment for Chronic Back Pain
Authors: Freeman Emily , Johnson Jennifer F. , Godbold, Jr John C. , Riegel Ronald J.
Published: December 2021

Historically, the evaluation and assessment of the clinical response to treatment for canine back pain is subjective and relies on owner and clinician assessment of pain. This study evaluated the use of sequential infrared thermal images as a measure of the response of canine patients with back pain to a prescribed series of photobiomodulation therapy (PBMT) treatments. Qualifying participants had histories of pain and dysfunction associated with spinal osteoarthritis or intervertebral disk disease, or of non-specific uni- or bilateral back pain along the paravertebral epaxial muscles. Each patient was initially thermally imaged prior to PBMT treatment and then received multiple PBMT treatments delivered to the appropriate spinal area on days 1, 2, 3, and 4. Participants were reimaged on day 7. Thermal images provided an objective measure of superficial temperature changes over the area of PBMT treatment of each patient after the PBMT regimen. The temperature correlated with statistically significant changes in Colorado State University Canine Chronic Pain Scale scoring (CPS) and owner assessment using the Canine Brief Pain Inventory (CBPI), which includes a Pain Severity Score (PSS) and Pain Interference Score (PIS). The correlation of objective thermal imaging data with more subjective outcome measures suggests thermal imaging may be a valuable additional tool in monitoring therapy outcome.
Spin Orbit Coupling in Orthogonal Charge Transfer States: (TD-)DFT of Pyrene - Dimethylaniline
Authors: Bissesar Shivan , Raamsdonk Davita M. E. van , Gibbons Dáire J. , Williams René M.
Published: December 2021

The conformational dependence of the matrix element for spin-orbit coupling and of the electronic coupling for charge separation are determined for an electron donor-acceptor system containing a pyrene acceptor and a dimethylaniline donor. Different kinetic and energetic aspects that play a role in the spin-orbit charge transfer intersystem crossing (SOCT-ISC) mechanism are discussed. This includes parameters related to initial charge separation and the charge recombination pathways using the (Semi-Classical) Marcus Theory for electron transfer. The spin-orbit coupling, which plays a significant role in charge recombination to the triplet state can be probed by (TD-)DFT, using the latter as a tool to understand and predict the SOCT-ISC mechanism. The matrix elements for spin-orbit coupling for acetone and 4-thio-thymine are used for benchmarking. (Time Dependent-) Density Functional Theory (DFT and TD-DFT) calculations are applied using the quantum chemical program Amsterdam Density Functional (ADF).
Quantum Gravity Theory Founded on Device That Generates Energy from Relative Acceleration Amongst Charged Particles Electrostatically Interacting Under Curvature Deviation
Authors: Moss Samuel
Published: December 2021

This is an introduction to a new concept of quantum gravity that seamlessly merges General Relativity to the Standard Model. Based upon a novel patent-pending magnetic confinement method that was designed to emulate how our sun confines and rotates charged particles about a singularity; this confinement method uses a collective of off-centered confinement coils that are directed to curve rotating charged particles about a singularity in a way that allows charged particles to relatively accelerate from geodesic deviation. With this confinement method, the subtle Relative Accelerated Energy (RAE) from deviating charged particles has the capability to be focused and exponentially increased relative to the mass-energy of a closed system; which allows for a simple pathway to understand how black holes operate at their singularities. While in the pursuit of proving that this novel method of confinement mimics how our sun operates; I was also able to develop a logical explanation of how our sun reverses its magnetic poles and cycles using the core principles of Michael Faraday. If this concept of quantum gravity is correct, there is a simple explanation for the additional observed gravitational force about the galaxies that are said to obtain dark matter. In short, this theory of quantum gravity has the potential to fully discredit the existence of theorized dark matter with a simple experiment.
Multifunctional Eco-Friendly Synthesis of ZnO Nanoparticles in Biomedical Applications
Authors: Al-Mohaimeed Amal Mohamed , Al-Onazi Wedad Altuhami , El-Tohamy Maha Farouk
Published: December 2021

This study describes an eco-friendly synthesis of ZnO nanoparticles using aqueous oat extract. The advanced electrochemical and optical features of green synthesized ZnONPs displayed excellent antibacterial activity, and exhibited an important role in pharmaceutical determinations. The formation of nanoscale ZnO was confirmed using various spectroscopic and microscopic investigations. The formed nanoparticles were found to be around 100 nm. The as-prepared ZnONPs were monitored for their antibacterial potential against different bacterial strains. The inhibition zones for ZnONPs were found as E. coli (16 mm), P. aeruginosa (17 mm), S. aureus (12 mm) and B. subtilis (11 mm) using 30 µg mL-1 sample concentration. Also, ZnONPs exhibited significant antioxidant effects 58 to 67 % with an average IC50 value of 0.88 ± 0.03 scavenging activity and 53 to 71 % (IC50 value 0.73 ± 0.05) against the DPPH and ABTS scavenging free radicals, respectively. The photocatalytic potential of ZnONPs for Rhodamine B dye degradation dye under UV irradiation was performed. The photodegradation process was carried out as a function of time-dependent and the complete degradation (nearly 98 %) with color removal after 120 min. Conclusively, the synthesized ZnONPs using oat biomass might provide a great promise in the future for biomedical applications.
The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintaining
Authors: Kutova Olga , Pospelov Anton , Balalaeva Irina
Published: December 2021

The modern paradigm of studying the processes of carcinogenesis and vital activity of tumor tissues implies increased attention to constituents of tumor microenvironment (TME) and their interactions. These interactions between the cells in TME can be mediated via protein junctions of different types. Connexins (Cnxs) are one of the major contributors to intercellular communication. They form gap junctions responsible for the transfer of ions, metabolites, peptides, miRNA, etc. between neighboring tumor cells as well as between tumor and stromal cells. Cnx hemichannels mediate purinergic signaling and bidirectional molecular transport with the extracellular environment. Additionally, Cnxs were reported to localize in tumor-derived exosomes and facilitate the release of their cargo. A large body of evidence implies that the role of connexins in cancer is multifaceted. Pro- or anti-tumorigenic properties of connexins are determined by their abundance, localization and functionality as well as channel assembly and non-channel functions. In this review we have summarized the data on the Cnxs contribution in TME and to the cancer initiation and progression.
A Multi-Scale Modelling of Aggregation of TiO2 Nanoparticle Suspensions in Water
Authors: Mancardi Giulia , Alberghini Matteo , Aguilera-Porta Neus , Calatayud Monica , Asinari Pietro , Chiavazzo Eliodoro
Published: December 2021

Titanium dioxide nanoparticles have risen concerns about their possible toxicity and the European Food Safety Authority recently banned the use of TiO2 nano-additive in food products. Following the intent of relating nanomaterials atomic structure with their toxicity without having to conduct large scale experiments on living organisms, we investigate the aggregation of titanium dioxide nanoparticles using a multi-scale technique: starting from ab initio Density Functional Theory to get an accurate determination of the energetics and electronic structure, we switch to classical Molecular Dynamics simulations to calculate the Potential of Mean Force for the connection of two identical nanoparticles in water; the fitting of the latter by a set of mathematical equations is the key for the upscale. Lastly, we perform Brownian Dynamics simulations where each nanoparticle is a spherical bead. This coarsening strategy allows studying the aggregation of a few thousand nanoparticles. Applying this novel procedure, we find three new molecular descriptors, namely, the aggregation free energy and two numerical parameters used to correct the observed deviation from the aggregation kinetic described by the Smoluchowski theory. Molecular descriptors can be fed into QSAR models to predict the toxicity of a material knowing its physicochemical properties, without having to conduct large scale experiments on living organisms.
Molecular Characterization of Circulating DENV-2 During Outbreak in Northern Senegal, Rosso 2018
Authors: Dieng Idrissa , Ndiaye Mignane , Ndione Marie Henriette , Sankhe Safietou , Diagne Moussa Moïse , Sagne Samba Niang , Gaye Aboubacry , Barry Aliou , Fall Gamou , Sall Amadou Alpha , Loucoubar Cheikh , Faye Oumar , Faye Ousmane
Published: December 2021

Globally 390 millions of people are at risk of dengue infection; over the past 50 years the virus incidence increased thirty-fold. In Senegal, an unprecedented occurrence of outbreaks and sporadic cases was noticed since 2017. In October 2018 an outbreak of DENV-2 was reported in Rosso area in the north of Senegal at the border with Mauritania. Out of the 187 blood specimen samples collected, 27 were positives by qRT-PCR and 8 were serologically positive for DENV IgM. Serotyping using qRT-PCR reveals that isolates were positive for DENV-2. A subset of DENV-2 positives samples was selected and subjected to full genome sequencing followed by phylogenetic analysis. Analysis of 06 nearly completed genome sequences (n= 6) revealed that isolates belong to the cosmopolitan genotype and are closely related to the Mauritanian strains detected between 2017 and 2018 and those detected in many West African countries such as Burkina Faso or Cote d’Ivoire. Our results suggest a transboundary circulation of the DENV-2 cosmopolitan genotype between Senegal and Mauritania and call for a need of coordinated surveillance of arboviruses between these two countries. Interestingly, high level of homology between West African isolates highlights endemicity and call for a set-up of sub-regional viral genomic surveillance which will lead to a better understanding of viral dynamic, transmission and spread across Africa.
RNA Therapeutics – The Next Generation of Drugs for Cardiovascular Diseases
Authors: Bejar Nada , Tat Trinh , Kiss Daniel
Published: December 2021

Abstract Purpose of review: RNA therapeutics are a new and rapidly expanding class of drugs to prevent or treat a wide spectrum of diseases. We discuss the defining characteristics of the diverse family of molecules under the RNA therapeutics umbrella. Recent findings:RNA therapeutics are designed to regulate gene expression in a transient manner. For example, depending upon the strategy employed, RNA therapies offer the versatility to replace, supplement, correct, suppress, or eliminate the expression of a targeted gene. RNA therapies include antisense nucleotides, microRNAs and small interfering RNAs, RNA aptamers, and messenger RNAs. Further, we discuss the mechanism(s) by which different RNA therapies either reduce or increase the expression of their targets. Summary: We review the RNA therapeutics approved (and those in trials) to treat cardiovascular indications. RNA-based therapeutics are a new, rapidly growing class of drugs that will offer new alternatives for an increasing array of cardiovascular conditions.
Severe Asthma, Telemedicine, Self-Administered Therapy: Listening First to the Patient
Authors: Guarnieri Gabriella , Caminati Marco , Achille Alessia , Vaia Rachele , Chieco Bianchi Fulvia , Senna Gianenrico , Vianello Andrea
Published: December 2021

Severe asthma patients are at increased risk of major exacerbations and they need to be monitored regularly. The COVID-19 pandemic has impressively impacted on the health care resources. The telemedicine approach applied to the follow-up of asthmatic patients has been proved to be effective in monitoring their disease and adherence to the therapy. The aim of our study was to investigate the satisfaction of severe asthma patients, before the activation of a telemedicine management complemented by a standard of care. An ad hoc questionnaire was developed and sent by e-mail to 180 severe asthma patients. Most of subjects (82%) were confident with the idea of doing self-measurements and self-managing their disease; 77% of subjects favoured to carry out virtual visit and telemedicine. 93% of patients considered easy the self-injection therapy. 94% of subjects felt safe and 93% were not worried while self-administering. Only mild adverse events were reported in 22% subjects after self-administration. Our results showed an agreement between what is considered necessary and practicable by healthcare personnel and what is perceived by the severe asthma patients, in terms of treatment and monitoring of the disease with Telehealth. Biologics have a safety profile and can be easily self-administred at home
Experimental Proof of a Solar-powered Heat Pump System for Permafrost Thermal Stabilization
Authors: Sharaborova Elizaveta S. , Shepitko Taisia V. , Loktionov Egor Y.
Published: December 2021

We have suggested earlier a new sustainable method for permafrost thermal stabilization that combines passive screening of solar radiation and precipitation with active solar-powered cooling of the near-surface soil layer thus preventing heat penetration in depth. Feasibility of this method has been shown by calculations, but needed experimental proof. In this article, we are presenting the results of soil temperature measurements obtained at the experimental implementation of this method outside of the permafrost area which actually meant higher thermal loads than in Polar Regions. We have shown that near-surface soil layer is kept frozen during the whole summer, even at air temperatures exceeding +30°C. Therefore, the method has been experimentally proven to be capable of sustaining soil frozen even in more extreme conditions than expected in permafrost areas. In addition to usual building and structure thermal stabilization, the method could be used to prevent the development of thermokarst, gas emission craters, and landslides; greenhouse gases, chemical, and biological pollution from the upper thawing layers at least in the area of human activities; protection against coastal erosion; and permafrost restoration after wildfires. Using commercially widely available components, the technology can be scaled up for virtually any size objects.
Plasmodium falciparum Dihydroorotate Dehydrogenase, Fragment-based Drug Design, 2D-QSAR, DFT Calculation, Lead Optimization, Induced Fit Docking
Authors: Iwaloye Opeyemi , Elekofehinti Olusola , Olawale Femi , Chukwuemeka Prosper , Babatomiwa Kikiowo , Folorunso Ibukun
Published: December 2021

Plasmodium falciparum dihydroorotate dehydrogenase (PfDODH) is one of the enzymes currently explored in the treatment of malaria. Although there is currently no clinically approved drug targeting PfDODH, many of the compounds in clinical trials have [1, 2, 4,] triazolo [1, 5-a] pyrimidin-7-amine backbone structure. This study sought to design new compounds from the fragments of known experimental inhibitors of PfDODH. Nine experimental compounds retrieved from Drug Bank online were downloaded and broken into fragments using Schrodinger power shell; the fragments were recombined to generate new ligand structures using BREED algorithm. The new compounds were docked with PfDODH crystal structure, after which the compounds were filtered with extensive drug-likeness and toxicity parameters. A 2D-QSAR model was built using the multiple linear regression method and externally validated. The compounds electronic behaviours were studied using DFT calculations. Structural investigation of the six designed compounds, which had lower binding energies than the standard inhibitors, showed that five of them had [1, 2, 4,] triazolo [1, 5-a] pyrimidin-7-amine moieties and interacted with essential residues at the PfDODH binding site. In addition to their drug-like and pharmacokinetic properties, they also showed minimal toxicities. The externally validated 2D-QSAR model with R2 and Q2 values of 0.6852 and 0.6691, confirmed the inhibitory prowess of these compounds against PfDODH. The DFT calculations showed regions of the molecules prone to electrophilic and nucleophilic attack. The current study thus provides insight into the development of a new set of potent PfDODH inhibitors.
Ruin Probabilities and Complex Analysis
Authors: Leung Andrew
Published: December 2021

This paper considers the solution of the equations for ruin probabilities
in infinite continuous time. Using the Fourier Transform and certain results
from the theory of complex functions, these solutions are obtained as com-
plex integrals in a form which may be evaluated numerically by means of
the inverse Fourier Transform. In addition the relationship between the re-
sults obtained for the continuous time cases, and those in the literature, are
compared. Closed form ruin probabilities for the heavy tailed distributions:
mixed exponential; Gamma (including Erlang); Lognormal; Weillbull; and
Pareto, are derived as a result (or computed to any degree of accuracy, and
without the use of simulations).
Influence of Hydrogen Generation During Thermal Processes of Water Decomposition on the Surface of Nano- ZrO2+3 mol.%Y2O3
Authors: Imanova Gunel , Asgerov Elmar , Jabarov Sakin , Kaya Mustafa , Doroshkevich Aleksandr
Published: December 2021

The physicalchemistry properties and crystal structure of were nano-ZrO2+3mol.%Y2O3 determined. The kinetics of the formation of H2 as a result of the decomposition of H2O on the surface of nano-ZrO2+3mol.%Y2O3 was studied. Effects of adsorption and desorption process on ZrO2+3 mol.%Y2O3 nanoparticles were studied at different (T=400÷10000C) temperature. The study of H2 in thermal processes at nano-ZrO2+3 mol.%Y2O3 system increased. Such an increase in H2 generation in comparison with a pure H2O as thermal processes had formedactive centers for H2O decomposition on the surface of the catalyst at the expense of δ-electrons emitted on the surface of nano-ZrO2+3 mol.%Y2O3. This showed that the dimensions of the studied nanoscale particles systems are comparable to the free running distance of energy carriers generated by of nano-ZrO2+3 mol.%Y2O3 as a result of thermal processes. These results are promising for hydrogen generation by waer spliting in near future.
Representing Geographic Space as a Hierarchy of Recursively Defined Subspaces for Computing the Degree of Order
Authors: Jiang Bin , de Rijke Chris
Published: December 2021

As Christopher Alexander discovered, all space or matter – either organic or inorganic – has some degree of order in it according to its structure and arrangement. The order refers to a kind of structural character, called living structure, which is defined as a mathematical structure that consists of numerous substructures with an inherent hierarchy. Across the hierarchy, there are far more small substructures than large ones, while on each level of the hierarchy the substructures are more or less similar in size. In this paper we develop a new approach to representing geographic space as a hierarchy of recursively defined subspaces for computing the degree of order. A geographic space is first represented as a hierarchy of recursively defined subspaces, and all the subspaces are then topologically represented as a network for computing the degree of order of the geographic space, as well as that of its subspaces. Unlike conventional geographic representations, which are mechanical in nature, this new geographic representation is organic, conceived, and developed under the third view of space; that is, space is neither lifeless nor neutral, but a living structure capable of being more living or less living. Thus, the order can also be referred to as life, beauty, coherence, or harmony. We applied the new representation to three urban environments, 253 patterns, and 35 black-white strips to verify it and to demonstrate advantages of the new approach and the new kind of order. We further discuss the implications of the approach and the order on geographic information science and sustainable urban planning.
Atomistic modeling of the propagation of the melting/crystallization front for metals based on the generalization of the modified transition state theory
Authors: Mazhukin Vladimir Ivanovich , Shapranov Alexander Viktorovich , Koroleva Olga Nikolaevna , Mazhukin Alexander Vladimirovich
Published: December 2021

Based on the modification of the well-known kinetic model with the Wilson-Frenkel diffusion constraint, a new kinetic model of the propagation velocity of the solid/liquid interface in various metal crystals (fcc - Al, Cu) and (bcc - Fe) has been developed in a wide temperature range, including the range of maximum permissible overheating/subcooling values. Molecular dynamics modeling of melting/crystallization processes of Al, Cu and Fe under deep overheating/overcooling conditions has been performed using 3 interaction potentials of the EAM family. By comparing the simulation results with the data of the modified kinetic model, the interface speed response function in the region of the maximum permissible values of overheating/overcooling in metals is constructed. The temperature dependence of the velocity of the interface is diffusion-limited and is described by the same equation for each metal in the entire temperature range.
Development of a method for identification of the state of computer systems based on bagging classifiers
Authors: Gavrylenko Svitlana , Hornostal Oleksii
Published: December 2021

The subject of the research is methods and means of identifying the state of a computer system . The purpose of the article is to improve the quality of computer system state identification by developing a method based on ensemble classifiers. Task: to investigate methods for constructing bagging classifiers based on decision trees, to configure them and develop a method for identifying the state of the computer system. Methods used: artificial intelligence methods, machine learning, ensemble methods. The following results were obtained: the use of bagging classifiers based on meta-algorithms were investigated: Pasting Ensemble, Bootstrap Ensemble, Random Subspace Ensemble, Random Patches Ensemble and Random Forest methods and their accuracy were assessed to identify the state of the computer system. The research of tuning parameters of individual decision trees was carried out and their optimal values were found, including: the maximum number of features used in the construction of the tree; the minimum number of branches when building a tree; minimum number of leaves and maximum tree depth. The optimal number of trees in the ensemble has been determined. A method for identifying the state of the computer system is proposed, which differs from the known ones by the choice of the classification meta-algorithm and the selection of the optimal parameters for its adjustment. An assessment of the accuracy of the developed method for identifying the state of a computer system is carried out. The developed method is implemented in software and investigated when solving the problem of identifying the abnormal state of the computer system functioning. Conclusions. The scientific novelty of the results obtained lies in the development of a method for identifying the state of the computer system by choosing a meta-algorithm for classification and determining the optimal parameters for its configuration.