bluuebunny/crossref_metadata_2025 huggingface dataset:
The AHP Method Implementation for ERP Software Selection with Regard to the Data Protection Criteria
Authors: Malindzakova Marcela , Puskas Dominik
Published: October 2024

The area of planning, management and process level assessment in enterprises, whether in small firms or multinationals companies, requires flexible and quality information systems. Within any company the management of the information system plays an important role. Throughout the organization, rapid and accurate transmission of information through information channels is needed, where there is a possibility for the application of basic logistics principles (system approach, coordination, planning, algorithmic thinking, global optimization). The need for information transfer, management as well as information systems is to identify and review criteria to ensure the flexibility and quality of the process level. The aim of this paper is to analyse the criteria for selecting the information system into a production company using the AHP method. In addition to the criteria for choosing an information system, the need to protect proprietary information assets is also required. The protection of information assets involves identifying and analysing risk criteria with a link to security risks for selected processes.
Analysis of Apache Logs Using Hadoop and Hive
Authors: Velinov Aleksandar , Zdravev Zoran
Published: October 2024

In this paper we consider an analysis of Apache web logs using Cloudera Hadoop distribution and Hive for querying the data in the web logs. We used public available web logs from NASA Kennedy Space Center server. HDFS (Hadoop distributed file system) was used as a logs container. The apache web logs were copied to the HDFS from the local file system. We made an analysis for the total number of hits, unique IPs, the most common hosts that made request to the NASA server in Florida, the most common types of errors. We also examined the ratio between the number of rows in the logs and the time of execution.
Industry 5.0 as a triumph of posthumanism: From Homo Sapiens to Homo Digitalis
Authors:   Saratov State University of Genetics, Biotechnology and Engineering named after N. I. Vavilov, Kraynov Andrey L.
Published: October 2024

Introduction. The article is devoted to the problem of transformation of a man into a post-human due to the emergence of the fifth industrial revolution. The digitalization processes inherent in industry 4.0 have become so firmly entrenched in human everyday life that they change it from the inside. Interaction with artificial intelligence and cobots creates a post-human future, and implantation of a chip in the brain creates a post-human. Theoretical analysis. The industry 5.0 phenomenon is associated with the active use of robotics and artificial intelligence in all spheres of human activity. The peculiarity of this stage of the industrial revolution lies in the human-oriented nature of technology and the establishment of a balance between nature and the technosphere. However, as a result of these processes, a person loses his own self and the status of a subject of cognition. There is a transition from Homo Sapiens to Homo Digitalis. Conclusion. The fifth industrial revolution can be considered the triumph of posthumanism. Techno-optimism, faith in scientific and technological progress and artificial intelligence cast doubt on the fact of the disappearance of a man as the culprit of these phenomena. Why create posthuman existence if a man loses his essence in it? Homo Digitalis is like a signifier without a signified - a talking head, devoid of its own consciousness and intelligence.
Anticolonial revolution and the social mission of philosophy
Authors:   Institute of Scientific Information for Social Sciences (INION) of the Russian Academy of Sciences, Mikhel Dmitry V.
Published: October 2024

Introduction. The question of the social role of philosophy in the context of anticolonial revolution, is discussed. Defending its sovereignty and freedom on the battlefields, Russia today faces the need to preserve its traditional values, to get rid of colonial dependence on the West at the intellectual, cultural and philosophical level. Theoretical analysis. It is shown that the system of higher education has two functions - training of specialists and education of citizens. After the collapse of the USSR, the domestic education system lost the function of educating citizens, turning into a system of production of consumers of Western ideas and technologies. An important role in this transformation was played by the “philosophical perestroika” of the late 1980s, which turned university philosophy into a translator of Western ideas and approaches. The beginning of the special military operation and the next round of confrontation between Russia and the collective West set before the Russian philosophical community the task of freeing itself from Western philosophical influence and standing up for traditional spiritual and moral values. Conclusion. An important reference point for the philosophical community in the new context is Presidential Decree No. 809, adopted in November 9, 2022.
The Liability of Pedestrians for Misuse of Bicycle Lanes
Authors:   Associate Professor of the Department of Legal Disciplines of the University for Humanities and Technologies, PhD (Law), Scherbinina Irina V.
Published: October 2024

The relevance of the study lies in the fact that in the last few years, mainly in large settlements, the number of bicycle paths has been increasing, which means that the number of those who can use them for their intended purpose is increasing. There is no consensus among cyclists, especially experienced cycling enthusiasts, as well as professional cyclists, about the need for bike paths. However, according to the results of our survey of 5,462 cyclists, more than 80% of the respondents noted among the facts that do not suit them in the organization of traffic in relation to a bicycle, namely the lack of a properly organized bicycle infrastructure and, in particular, an insufficient number of bike paths. Given the low culture of pedestrians, who, in the presence of bike paths in a locality, become "rivals" of cyclists, the latter themselves are exposed to danger and expose persons walking along bike paths in violation of traffic regulations of the Russian Federation to it. This article is devoted to methods of preventing the risk of harm to road users in relation to the designated legal relations.
Agreement of Rent of Transport Vehicles by the Minute (Carsharing)
Authors:   Lecturer of the Department of Civil Law of the Russian State University of Justice, Maltseva Tatyana G.
Published: October 2024

The transformation of public relations under the influence of digitalization, as well as the intensification of property turnover, contributed to the formation of an economic model of sharing, which is often referred to through the prism of the English term "sharing". A striking example of such a model is carsharing, based on the idea of "mobility on demand" and being a predictable alternative to personal transport in the future. It is assumed that in the future, car owners, giving priority to car-sharing services, will give up ownership of a car, which will significantly accelerate urban traffic, free up parking spaces, and reduce the anthropogenic burden on the environment. Despite the prevalence of carsharing, especially in large and resort cities of Russia, its federal legal regulation has not yet been presented: to date, only regional experience of such regulation is known. At the same time, there are many issues in this subject area, some of which are solved by law enforcement practice. The key issue discussed in this scientific article is the choice of a contractual structure that could become an adequate model of carsharing relations.
VEPRe. A Mixed-Method Approach for Including Sociological Profiles in Audience Segmentation for Communication Campaigns
Authors: Cougnon Louise-Amélie , Anciaux Amélie
Published: October 2024

The VEPRe model aims at providing practical recommendations in times of crises through a mixed-method approach for audience segmentation leading to the creation of sociological profiles. The model inherits from theoretical models in audience segmentation from the distinct disciplines of marketing, psychology, sociology, linguistics, and anthropology. We propose a model divided into four main dimensions: values, emotions, practices, and relations to the norm. This model, whose approach is deliberately empirical, is an answer to the limits of entirely statistical approaches that occasionally overlook some individuals, their systemic properties, and their complexity. In this model, audience segmentation is predictive as it aims to define levers of action for each persona that lead to conversion, empowerment, a mind-shift, higher trust, role-modeling, or a better understanding of a given situation. The VEPRe method is inclusive (it allows individuals to belong to several groups) and flexible (it evolves over time and opens the way to the evolution and change of individuals). This grouping method also encourages the completion and mutual support between segments; it is a peer-supporting method.
Directions for ensuring the quality of gypsum-lime binders during restoration
Authors: Safonova Tatyana
Published: October 2024

Purpose: to consider issues related to the standard definition of the strength characteristics of an air binder and a cement binder. To show a technological solution to the problem of regulating the strength of an air binder stone by stabilizing care during setting and hardening. Methods: during the research, GOST 23789- 2018 “Gypsum binders. Test methods”. Results: a distinctive feature of restoration plaster solutions is that structure formation and strength gain occur only in an air-dry environment. As a result, the availability of approved and applied standards for the manufacture and use of restoration plaster solutions does not fully guarantee the creation of a reliable and safe environment for the life of an architectural heritage monument. It has been established that the mechanical characteristics (compressive and bending strength limits), as well as elastic parameters should be the same or lower in historical and restoration solutions in order to avoid changes in stress distribution. Practical significance: developed taking into account the comprehensive care of hardening stone, gypsum-lime binders can have a wide range of applications. They can be used as mortars for the preservation of architectural heritage and in the reconstruction of modern buildings, self-supporting partitions, fire protection elements or drywall (in places where a higher mechanical load is expected).
Analysis of the use of hydraulic vibration dampers in spring suspension structures of railway rolling stock
Authors: Treskin Sergey , Dulskiy Evgeny , Kruchek Viktor , Ivanov Pavel
Published: October 2024

Purpose: consideration of the issue of the use of hydraulic vibration dampers in spring suspension of various types of railway rolling stock. The article provides an overview of the layout of hydraulic vibration dampers in the spring suspension of rolling stock, their advantages and disadvantages are given Methods: review and analysis of spring suspension designs of various types of traction and non-traction rolling stock in operation, as well as patented designs. Analysis of the arrangement schemes of hydraulic vibration dampers in the spring suspension of rolling stock. Results: the main reason for the use of hydraulic dampers in spring suspension is the inability of cylindrical springs to minimize the influence of oscillatory movements of rolling stock that occur during its movement. The necessity of using hydraulic vibration dampers in structures of various types of rolling stock is substantiated. The arrangement schemes of hydraulic vibration dampers are considered. Examples of the use of hydraulic dampers in spring suspension of various types of rolling stock are given. Practical significance: the necessity of using hydraulic vibration dampers is shown not only in the structures of the undercarriage of passenger cars and locomotives, but also in the spring suspension of freight cars. The use of hydraulic vibration dampers makes it possible to minimize the negative impact of oscillatory movements on both the structure of the rolling stock and the health of passengers and locomotive crews, as well as to increase the comfort of their stay. The use of hydraulic dampers in the spring suspension of freight rolling stock can increase the speed of its movement by improving the running qualities of freight cars and the degree of safety of transported goods.
Evaluation of proposals for the formation of a network of alternative routes for the “North-South” corridor
Authors: Ryazanova Ekaterina , Nauruzbaev Sabir , Kudelina Angelina
Published: October 2024

Purpose: to develop proposals for the development of the expected growth in traffic volumes along the North–South transport corridor. To assess the capacity of the Upper Baskunchak — Astrakhan — Olya port section as the most heavily loaded, where cargo flows from several directions merge. To show the need to unload the main direction of the North-South corridor and form a network of alternative routes in the transport corridor to ensure transportation guarantees in case of force majeure. Consider the possibility of attracting parallel routes through the North Caucasus Railway (SKZHD). Methods: the calculation of throughput was carried out using the methodology used in JSC “Russian Railways” and the author’s proposals, taking into account additional reserves of throughput. General logical methods were used — quantitative and qualitative analysis and synthesis, induction and deduction, analogies, classifications, a combination of historical and logical analyses. The proposed universal algorithm, which makes it possible to evaluate the possibility of choosing parallel moves, can be recommended for practical use. Results: the maximum number of trains that can be redirected to parallel routes has been established, taking into account the available capacity and their workload with export cargo traffic in the direction of the ports of the Azov-Black Sea basin. The relevance of the direction of development of heavy traffic aimed at reducing the required capacity and reducing inter-train intervals to increase the available capacity is shown. A universal algorithm has been formed that allows evaluating the possibility of choosing parallel moves. Practical significance: the necessity of mastering the expected cargo flow and preventing its departure to competing destinations, for example, through the Suez Canal, is shown. In the current political and economic conditions, the North — South International Transport Corridor (ITC) is changing its status: from an alternative to the Suez Canal, it is becoming one of the priority routes for Russian export cargo traffic.
The method of supplying fuel to an internal combustion gas engine
Authors: Vorob'ev Aleksandr , Penkin Aleksey , Vedernikova Dar'ya
Published: October 2024

Purpose: due to the significant disadvantages of the most commonly implemented fuel supply methods in gas engines, the goal was set to develop a new method of fuel supply. The advantages and disadvantages of existing methods of fuel supply in gas engines, such as central, distributed and direct supply, fuel supply through a dual-fuel nozzle, are considered. Methods: on the basis of distributed and direct fuel supply, a combined method was developed, which is a combination of these types of fuel supply. Results: this method of fuel supply compensates for the disadvantages of distributed supply (reduction of cylinder filling, accumulation of fuel-air mixture in the intake system and fuel losses at valve closures) and direct (poor-quality mixing in low and full load modes). In different engine operating modes, these types of fuel injection are used in different combinations, which is why the advantages of distributed and direct fuel injection are summed up. In areas of low loads, distributed injection is carried out, or a combination of distributed and direct injection. At medium loads, only direct injection is possible. At full load, it is possible to inject fuel from two injectors in one cycle. An improvement of the distributed feed as part of the combined one is proposed in order to eliminate fuel a ccumulation in the intake manifold. This effect is achieved through the use of an electronically controlled gearbox, which allows fuel to be supplied with different pressure values to create a directional movement of the gas jet, which also improves mixing. Practical importance: the proposed method of supplying natural gas ensures the optimal composition of the fuel-air mixture in all operating modes, increasing the filling ratio, eliminating fuel losses on valve closures.
Problems of search and pursuit of unmanned aerial vehicles using the game-theoretic approach
Authors: Malafeev Oleg , Chzhan Kun' , Zayceva Irina , Garanin Anton
Published: October 2024

Currently, the application of mathematical modeling theory is widely used in various fields and, among other things, can be used to prevent illegal actions. This study examines scenarios involving a single pursuer tracking a single evader, as well as situations involving multiple pursuers pursuing multiple evaders. The authors formulate this problem as a search and pursuit problem for four-rotor unmanned aerial vehicles (UAVs) or quadcopters. The solution to the problem is based on game theory, as it provides a mathematical framework for modeling and studying strategic interactions involving multiple decision makers. The authors consider a game where the set of strategies of the runner is the set of possible combinations of speeds and directions of his movement, and the set of strategies of the pursuer is the set of all possible permutations of the elements of his speeds. The matrix of the resulting game consists of elements that are the time of capture. A mathematical problem on the optimal assignments of searching and pursuing unmanned aerial vehicles is formulated and solved. Purpose: optimizing the effectiveness of strategies for detecting and capturing four-rotor unmanned aerial vehicles (quadcopters). Methods: methods of mathematical modeling, game theory apparatus, Hungarian method of solving the problem of assignments, decision theory, the principle of dynamic programming, the Maple package for solving examples were used. Results: In order to fulfill the conditions for solving the problem of optimal assignments, it is necessary and sufficient that it is balanced. This assignment problem can be balanced by entering the required number of fictitious boats or escaping boats. After that, it is possible to formulate and solve the dual problem of optimal appointments. The resulting game can be solved by any method of solving matrix games. In this way, it is possible to determine the policy of harassment and search between drones. Practical importance: All escaped quadcopter UAVs can be chased and successfully intercepted using the developed models. Examples of the study of mathematical models using the Maple software package are given.
Formation of objective indicators of marshalling yard performance based on data “from the wheel”
Authors: Hatlamadzhiyan Agop , Ol'geyzer Ivan , Suhanov Andrey , Ierusalimov Vladislav
Published: October 2024

The paper presents a new principle for forming freight marshalling yard indicators based on the use of data from various reading devices and sensors located on the station tracks (data “from the wheel”). The paper shows the relevance and objectivity of using the proposed approach, implementing the presented principles for obtaining real freight yard indicators. The implementation is presented on the basis of data generated by the system for monitoring and preparing information on the movements of wagons and locomotives at the station in real time. The difference between the results obtained as a result of implementing the proposed approach and the information generated in real certificates and reporting journals of Russian Railways JSC is shown. Hypotheses-descriptions of the difference between information “from the wheel” and information obtained by manual input of data on the movements of cars and locomotives are proposed. The conclusion describes further prospects for automation of calculation and forecasting of station operation based on data “from the wheel”.
Modular sum codes with a sequence of weight coefficients forming a natural number series excluding powers of two
Authors: Efanov Dmitriy , Elina Eseniya
Published: October 2024

The paper presents the results of studies on the characteristics of modular weight-based sum codes, where the sequence is formed by a natural series of numbers excluding powers of two. The consideration of the studied characteristics is advisable when developing discrete systems and their diagnostic support. Catalogs of the considered codes obtained using modules M = 4, 8, 16, 32, and 64 are provided. The choice of these specific modules is due to the fact that the number of check symbols in the codewords of the considered codes is small, which minimizes structural redundancy when constructing discrete systems and their diagnostic support, resulting in self-checking, controllable, and fault-tolerant structures. Modular weight-based sum codes detect all single errors with the number of data symbols . It is also demonstrated that the considered codes detect no fewer errors than the well-known modular sum codes of single digits (classical modular sum codes). As the module value increases, the gain in the tota number of errors detected by the modular weighted codes compared to classical modular codes significantly increases. Modular weighted codes are more effective at detecting multidirectional errors of even multiplicity in data vectors containing groups of distortions {0→1, 1→0} (symmetric errors) than classical modular sum codes. However, modular weight-based sum codes are less effective in handling asymmetric errors occurring in data vectors. In an experiment with test combinational circuits, it was shown that modular weighted codes with a module M = 4 do not detect more errors occurring at circuit outputs than classical modular codes with this module. Modular weight-based sum codes and a module M = 8 have slightly better characteristics. However, a general recommendation is to use modules that are powers of two starting from M = 16. Increasing the module allows for an increase in the number of detectable errors at the outputs of benchmarks, up to 100 % coverage. Modular weight-based sum codes, with a sequence of weight coefficients forming a natural series of numbers excluding powers of two, can be effectively used in the development of discrete systems and their diagnostic support.
The Big Bang Was Not the Beginning, but a Repeating Pattern of Expansion and Contraction of Spacetime
Authors: Ladhani Amrit
Published: October 2024

In this paper, I present a possible explanation for accelerated expansion of the universe, and introduce the cosmic scale, size of the universe and cosmic time, age of the universe. The observed expansion of the universe, which relates the stretching of Shrunk space to the new theory, is derived. This model is based on the two principal long-range forces: the gravitational force and the repulsive force generated by shrunk space. They are the two most basic fundamental quantities in the universe that govern cosmic evolution. They may provide the clockwork mechanism that operates our eternal cyclic universe. This model of Space-time and its unique properties of shrinking and stretching enables us to describe a sequence of events from the Big Bang to the Big Crunch.
Physics at a Crossroads: Weird Concepts or Orthogonal Projections
Authors: Niemz Markolf H.
Published: October 2024

Today’s physics describes nature in “subjective concepts” (concepts of observers), such as spatial, temporal, wave, particle, force, field. There are coordinate-free formulations of special relativity (SR) and general relativity (GR), but there is no absolute time in SR/GR. Thus, there is no “holistic view” (view from all possible perspectives at the same instant in time). I show: Euclidean relativity (ER) provides a holistic view by describing nature in “objective concepts” (concepts that are immanent in all objects). “Pure distance” replaces spatial and temporal distance. “Pure energy” replaces wave and particle. I give one example where “process” replaces force and field. Each object’s proper space d1, d2, d3 and its proper time τ span a Euclidean 4D spacetime (ES), where d1, d2, d3 and d4 = cτ are pure distances. The new invariant is absolute, cosmic time θ. All energy moves through ES at the speed c. An observer’s reality is created by orthogonally projecting ES to his proper space and to his proper time. The two projections are reassembled in SR/GR to form a non-Euclidean spacetime. Information is lost in all projections. Thus, there will always be unsolved mysteries if we ignore ES. Physics now has two options: (1) It rejects ER and continues with weird concepts (cosmic inflation, expanding space, dark energy, non-locality). (2) It accepts ER and solves 15 fundamental mysteries (including time’s arrow and the Hubble constant tension) without these weird concepts. All solutions are purely geometrical. In particular, they require neither forces nor fields.
Carcinogenesis of the Human Scalp. An Immunometabolic Centered View
Authors: Kaplan Baruch , von Dannecker Rebecca , Arbiser Jack
Published: October 2024

The human scalp is a common site of skin cancer in humans, with non-melanoma skin cancer being exceedingly common. In this review, two dermatologists with extensive experience in cutaneous oncology will discuss unique features of the epidemiology of cancer of the scalp. Clinical observations on these common skin cancers lead to insight into the pathogenesis and potential prevention and treatment of cutaneous scalp neoplasia. Our hypothesis is that the presence of hair protects against the development of skin cancer, but not by serving as a physical shield, but rather by providing a continuous IL-17 biased immunosurveillance. Loss of hair allow release from immunosurveillance, resulting in expansion of neoplastic cells towards skin cancer. Both hair follicles and metabolic changes in stroma allow permissiveness for tumor promotion.
Diagnostic Utility of Copeptin in Pediatric Patients with Polyuria-Polydipsia Syndrome: A Systematic Review and Meta-Analysis
Authors: Ciortea Diana-Andreea , Petrea (Cliveți) Carmen Loredana , Bujoreanu Bezman Laura , Vivisenco Iolanda Cristina , Berbece Sorin Ion , Gurău Gabriela , Matei Madălina Nicoleta , Nechita Aurel
Published: October 2024

Background: Pediatric patients with polyuria polydipsia syndrome (PPS) represent a diagnostic challenge for clinicians because of the technical difficulties in performing the gold standard water deprivation test (WDT). Copeptin, a stable biomarker representing the C-terminal portion of the polypeptide chain of antidiuretic hormone, proves to be a more reliable diagnostic tool. Objective: To assess the diagnostic accuracy of copeptin baseline dosing, arginine/saline copeptin stimulation tests, and WDT. Establishing the diagnostic utility of copeptin in pediatrics, for differentiating central and nephrogenic diabetes insipidus, and primary polydipsia. Methods: comparative and non-comparative primary studies, relating to children, were included and searched for in PubMed, Cochrane Library, WOS, ScienceDirect, Scopus, Google Scholar, up to August 2024. QUADAS-2 tool was used to assess risk of bias and applicability. Meta-analyses used fixed effect models due to low heterogeneity and the HSROC model. Results: 11 studies included, with an overall Low bias, no significant applicability concerns. The mean pooled sensitivity = 0.98 (95% CI: 0.936–1.025), pooled specificity=0.947 (95% CI: 0.920–0.973), and AUC=0.972 (95% CI: 0.952–0.992), indicating excellent diagnostic accuracy. Conclusion: Stimulation methods for copeptin dosing represent effective and less invasive diagnostic test for children with PPS, and future development of standard copeptin testing protocols are needed.
Translational Research on Azacitidine Post- Remission Therapy of Acute Myeloid Leukemia in Elderly Patients (QOL-ONE Trans-2)
Authors: Oliva Esther Natalie , Cuzzola Maria , Porta Matteo Della , Candoni Anna , Salutari Prassede , Palumbo Giuseppe A , Reda Gianluigi , Iannì Giuseppe , Zampini Matteo , D’Amico Saverio , Tripepi Giovanni , Capelli Debora , Alati Caterina , Cannatà Maria Concetta , Niscola Pasquale , Serio Bianca , Barillà Santina , Musto Pellegrino , Vigna Ernesto , Melillo Lorella Maria Antonia , Tripepi Rocco , Zannier Maria Elena , Nannya Yasuhito , Ogawa Seishi , Mammì Corrado
Published: October 2024

Achieving complete remission (CR) is crucial for acute myeloid leukemia (AML) patients undergoing curative therapy, but relapse often occurs within months, highlighting the need for strategies to prolong leukemia-free survival (DFS). Our phase III study compared the efficacy and safety of azacitidine (AZA) versus best supportive care (BSC) in elderly AML patients who achieved CR after intensive induction and consolidation therapy. This ancillary study (QOL-ONE Trans-2) evaluated biological changes in bone marrow using Next Generation Sequencing (NGS). We analyzed baseline, randomization, and 6-month post-remission samples from 24 patients (median age 71, 12 males). High-throughput NGS targeted 350 myeloid malignancy-related genes, considering variants with a Variant Allele Frequency (VAF) ≥ 4%. At diagnosis, all patients had 5 to 17 (median 10) mutations, with DNMT3A (42%), NPM1 (33%), and TET2 (33%) being most frequent. FANCA mutations in 4 patients were linked to a higher relapse risk (HR 4.96, p=0.02) for DFS at both 2 and 5 years. Further HLA-specific NGS analyses are ongoing to confirm these results and their therapeutic implications.
Relationship between the Mediterranean Diet and Arterial Stiffness, Metabolic Syndrome and its Components in People over 65 Years of Age
Authors: Gómez-Sánchez Leticia , Gómez-Sánchez Marta , García-Ortiz Luis , Agudo-Conde Cristina , Lugones-Sánchez Cristina , Sánchez Susana Gonzalez , Rodríguez-Sánchez Emiliano , Gómez-Marcos Manuel A.
Published: October 2024

The aims of the study were to analyze the relationship between the Mediterranean diet (MD) and arterial stiffness and metabolic syndrome (MetS) and its components in individuals aged over 65, overall and by sex. Subjects were people over 65 years of age with a full record of all variables analyzed from the EVA, MARK and EVIDENT studies. Data from 1,280 subjects with a mean age of 69.52±3.58 years (57.5% men) were analyzed. MD was recorded with the validated 14-item MEDAS questionnaire used in the PREDIMED study. MetS was defined following the guidelines of the joint scientific statement from the Programa Nacional de Educación sobre el Colesterol III. Arterial stiffness was assessed with the VaSera VS-1500® device by measuring the cardio-ankle vascular index (CAVI) and the brachial-ankle pulse wave velocity (baPWV). Results: The mean MEDAS score was 6.00 ± 1.90, (5.92 ± 1.92 in men, 6.11 ± 1.88 in women; p = 0.036). The mean CAVI value was 9.30 ± 1.11 (9.49 ± 1.05 men, 9.03 ± 1.13 women; p = <0.001). The mean baPWV value was 15.82 ± 2.56 (15.75 ± 2.46 men, 15.92 ± 2.68 women; p = <0.001). MetS was found in 51% (49% men, 54% women; p = 0.036). Subjects with MetS had lower MD adherence and higher arterial stiffness values than subjects without MetS. Overall, we found a negative association of MD score with the number of MetS components (β = -0.168), with glycemia (β = -0.007), triglycerides (β = -0.003), waist circumference (β = -0.018), CAVI (β = -0.196) and baPWV (β = -0.065), and a positive association with HDL cholesterol (β = 0.013). By sex, associations followed the same direction but without reaching statistical significance with blood glucose and triglycerides in women and with HDL cholesterol and waist circumference in men. Conclusion: Results indicate that greater adherence to the Mediterranean diet decreases arterial stiffness and the percentage of subjects with MetS, although results differed in the association with MetS components by sex.
Investigating the Riemann Hypothesis with HQF ASA and Modular Surfaces - a Detailed Description
Authors: Oliveira Hime
Published: October 2024

This article describes a new application of the global optimization method HQF ASA to the investigation of the Riemann hypothesis, in the sense of searching for zeros of the Riemann zeta function ζ outside the critical line but inside the (open) subset of the critical strip ((0,1/2)∪(1/2,1))×(−∞,∞). The underlying idea is very simple: a complex root r of a given complex function f : C → C must satisfy the condition ||f(r)|| = 0, that is, f(r) must have 2-dimensional Eu- clidean norm equal to 0, considering r as a point of R2. In the opposite direction, for any r ∈ C, ||f(r)|| = 0 implies f(r) = 0 and r is a root of f. Focusing again on the Riemann zeta function ζ, the open and simply connected region Rc = (1/2,1)×(0,∞) is used along the text, taking into account the symmetries of zeros of ζ in the critical strip. In this fashion, finding a global optimizer for ||ζ|| is equivalent to finding a root of ζ. Therefore, and taking into account the well-known efficacy of HQF ASA, a good sign of the trueness of RH would be not finding global minima in several optimization sessions with expanding subsets of Rc. In practical terms, several optimization sessions are executed using QMF ASA with increasing subsets of Rc, searching for global minima of ||ζ||. After presenting numerical results and figures, the adequacy of the proposed approach as a tool for preliminary empirical analysis for this type of problem is discussed.
Virtual Reality-Assisted Informed Consent for Anesthesia: A Prospective and Randomized Proof-of-Concept Study
Authors: Simon Sebastian , Opfermann Philipp , Hofstaetter Jochen , Marhofer and Peter
Published: October 2024

Background/Objectives: Informed consent for anesthesia poses both legal challenges and problems of understandable communication. Fulfilling all requirements through anesthesiologists directly interacting with patients is a time- and staff-consuming strategy. Given today's smart technologies, notably including virtual reality (VR), we explored in a prospective randomized study whether 'VR-assisted informed consent' could improve this situation. Methods: Fifty patients scheduled for orthopedic surgery were randomized. In the control group, informed consent was obtained via patient-specialist dialogs only. The patients in the study group, wearing a head-mount display, watched an 8-minute immersive 3D movie with standard explanations of general anesthesia, followed by a patient-specialist dialog to address open question. The time spent on the dialogs in both groups was evaluated as primary outcome variable. As secondary variables, we analyzed both a three-item Likert scale on patient satisfaction with the VR experience and cost differences between both groups. Results: Patient-specialist dialogs were carried on for median (IQR) durations of 93 (20–182) seconds in the study group versus 665 (261–829) seconds in the control group (P<0.001). All patients exposed to VR rated this experience as favorable (87.5%) or neutral (12.5%). Based on anesthesiologists' incomes in the US and UK, our approach would reduce the staff expenditure for each patient-specialist dialog by median amounts of ≈40 or ≈11 US dollars, respectively (2× P<0.001). Conclusions: 'VR-assisted informed consent' for anesthesia is well accepted by patients and reduces the time requirements for patient-specialist dialogs, thus pointing out a potential avenue towards increasing the work-time efficiency of anesthesiologists.
Evaluating Fitness in Older Acute Myeloid Leukemia Patients: Balancing Therapy and Treatment Risks
Authors: Molica Matteo , Canichella Martina , Jabbour Elias , Ferrara Felicetto
Published: October 2024

Assessing the suitability of older adults with acute myeloid leukemia (AML) to intensive chemotherapy or stem cell transplantation remains a long-standing challenge. Geriatric assessment, which evaluates multiple dimensions of health, may influence a patient's ability to tolerate intensive or mild intensity approach, including treatment related mortality. Prospective studies are needed to validate different fitness criteria as well as to compare the effectiveness of geriatric assessment–based fitness against other criteria, in order to identify which aspects of the geriatric assessment are linked to treatment tolerance. Hopefully, validation studies should include different group of patients receiving either intensive or lower-intensity chemotherapy. At a minimum, the geriatric assessment should measure comorbidity burden, cognition, physical function, and emotional health—factors previously associated with mortality in AML. These assessments should be conducted before starting chemotherapy in order to minimize the treatment's impact on the results. While treatment tolerance has traditionally been evaluated through toxicity rates in solid tumor patients, AML treatment often results in high toxicity rates regardless of intensity. Therefore, early mortality should be the primary endpoint for assessing treatment tolerance, given its significant and clear implications. Other important endpoints might include declines in functional status, quality of life, and treatment adjustments or discontinuation due to toxicities. Validating these fitness criteria is essential for guiding treatment choices, improving supportive care, determining trial eligibility, interpreting study outcomes, and informing drug labeling.
Analysis of Hierarchical Task Analysis (HTA) Impact
on cognitive workload using NASA TLX: A Study on
the Assembly of a Three Jaw Chuck
Authors: Patel KarthiK , E Hanumakeerthy , V.N Shailaja , B Ravishankar , Appaiah Mayur
Published: October 2024

HTA introduced by Annett and Duncan is widely recognized for breaking down
complex tasks into manageable subtasks, data, and quantitative analysis confirming
its effectiveness are limited. By combining the HTA with the NASA Workload Index
(NASA-TLX), a subjective workload assessment tool, this study aims to provide a
comprehensive assessment of task performance and workload. The project involved
assembling a three-jaw chuck with HTA for process definition and subtasks, while
NASA-TLX was used for workload determination. Data were collected through
questionnaires and observation forms and analyzed to determine the impact of HTA
on task performance and workload distribution. The results show that HTA effectively
identifies task complexity and bottlenecks, which facilitates task optimization and
improves performance. The NASA-TLX integration provides critical insights into
individuals' subjective workload and targets areas where task performance and
resource allocation can be improved. This study shows that combining HTA and
NASA-TLX provides a holistic approach to understanding and improving task
performance, ultimately leading to better user experience and productivity.
Mitigating the Adverse Effects of Salt Stress on Pepper Plants through the Utilization of Arbuscular Mycorrhizal Fungi (AMF) and Beneficial Bacterial (PGPR) Inoculation
Authors: Dere Sultan
Published: October 2024

Salinity is a major abiotic stress affecting agricultural productivity. This research investigated the impact of mycorrhizal fungi (AMF), bacteria (PGPR), and their combination on pepper plants under salt stress (200 mM NaCl). Conducted in a controlled climate chamber, the study assessed plant height, stem diameter, leaf number, leaf area, leaf weight, shoot fresh and dry weights, SPAD values, leaf relative water content (RWC), leaf water potential, and mineral concentrations (Na, K, Mg, Ca, P, Cu, Mn, Fe, Zn). AMF application significantly increased plant height (39.50 cm) compared to PGPR (37.75 cm) and the control (37.25 cm). While salt stress reduced plant height by 34.90%, AMF and PGPR mitigated these effects, with AMF improving height by 21.65% under saline conditions. AMF and PGPR positively influenced plant diameter, leaf number, and fresh weight. Physiological measurements, including SPAD values, RWC, and osmotic potential, showed that AMF+PGPR applications were most effective in increasing RWC. Nutrient analysis revealed reduced calcium and magnesium levels due to salt stress. In conclusion, AMF and PGPR enhanced pepper plants' growth and physiological responses under salt stress, indicating their potential to improve agricultural practices in saline environments.
Quetiapine in the ICU: A Paradigm Shift from Sedation to Targeted Delirium Therapy – a Comprehensive Review
Authors: Menozzi Alessandro , Gotti Miriam , Mantovani Elena Alessandra , Galimberti Andrea , Umbrello Michele , Mistraletti Giovanni , Sabbatini Giovanni , Pezzi Angelo , Formenti Paolo
Published: October 2024

Delirium and agitation are common and challenging issues in the intensive care unit (ICU), leading to longer hospital length of stay, prolonged need of mechanical ventilation, and higher costs. These conditions also increase the risk of complications and mortality. In the ICU setting it is common to observe an inappropriate use of sedatives and antipsychotics to manage agitation without an accurate diagnosis. Although the Richmond Agitation-Sedation Scale (RASS) has improved the reliability, accuracy, and specificity of delirium diagnosis, it is important to consider that delirium may be a symptom caused by a variety of diseases and medical conditions like sepsis rather than just a neurological problem. Antipsychotics, such as quetiapine, are often used in the ICU to manage these symptoms effectively. Quetiapine is a particularly valuable therapeutic option because of its capability to reduce agitation and delirium without significantly affecting the respiratory function, making it a safer choice for critically ill patients. This review explores quetiapine’s pharmacodynamics, side effects, efficacy, and recently described uses in the ICU. A comprehensive search was conducted across six major databases, and articles were assessed based on their relevance and quality. Our findings aim to provide a clear understanding of the application of quetiapine and its potential value in critical care settings.
On the Integration of Internet of Things and Machine Learning for Energy Prediction in the Wind Turbines
Authors: Emexidis Christos , Gkonis Panagiotis
Published: October 2024

Wind power has emerged as a crucial substitute for conventional fossil fuels. The combination of advanced technologies such as the internet of things (IoT) and machine learning (ML) has given rise to a new generation of energy systems that are intelligent, reliable, and efficient. The wind en-ergy sector utilizes IoT devices to gather vital data, subsequently converting them into practical insights. The aforementioned information aids among others in the enhancement of wind turbine efficiency, precise anticipation of energy production, optimization of maintenance approaches, and detection of potential risks. In this context, the main goal of this work is to combine the IoT with ML in the wind energy sector by processing weather data acquired from sensors to forecast wind power generation. To this end, three different regression models are evaluated. The models under comparison include Linear Regression, Random Forest, and Lasso Regression, evaluated us-ing metrics such as coefficient of determination (R²), adjusted R², mean squared error (MSE), root mean squared error (RMSE), and mean absolute error (MAE). After examining a dataset from IoT devices that included weather data, the models provided substantial insights regarding their ca-pabilities and responses to preprocessing, as well as each model's reaction in terms of statistical performance deviation indicators. Ultimately, the preprocessing and the data analysis show that Random Forest regression is more suitable for weather condition datasets than the other two re-gression models. Both the advantages and shortcomings of the three regression models indicate that their integration with IoT devices will facilitate successful energy forecasting.
Person-to-Person Bacterial Transmission Can Change the Sleep Pattern in Newly Married Couples
Authors: Rastmanesh Reza , Marotta Francesco
Published: October 2024

BACKGROUND: The composition of the gut microbiota varies significantly among healthy individuals and insomniacs, hypersomniacs and healthy people. On the other hand, there is a substantial bacterial strain shared across these populations with distinct intra-population, mother-to-infant and intra-household transmission patterns. Based on these premises, we propose a hypothesis stating that person-to-person bacterial transmission can change the sleep pattern in couples. SUBJECTS AND METHODS: In this pilot study, 157 couples who had been married and living together for an average of 5.91 months were enrolled. A wide range of questionnaires were administered to participants to measure sleep patterns. Gut microbiota composition was analyzed at two time points: baseline and 3 months. RESULTS: Three months after the marriage, spouses with healthy sleep pattern were significantly more likely to resemble their insomniac or hypersomniac couples. CONCLUSIONS: The research will have important implications in terms of diagnosis and treatment of sleep disturbances through microbiota modulation.
Existence of Two Solutions for $(p(x), Q(x))$-Laplacian
Authors: Mostafa Rahmani , Karim Belhadj , Abdellah Zerouali , Abdessamad Lakhdi
Published: October 2024

The present paper discusses an elliptic equation with Steklov boundary conditions and $(p(x),q(x))$-Laplacian. Using mountain pass theorem together with Ekeland's variational principle, we prove, under appropriate conditions on the functions involved, that the problem admits at least two solutions.