bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and effect of poultry lymphoid tissue supplement on cell viability in culture
Authors: Kolberg Natalia , Tikhonova Nataliya , Tikhonov Sergey , Leontieva Svetlana , Sergeeva Irina
Published: July 2022

Peptides are biologically active. This quality depends on the technological modes of protein hydrolysis. The research objective was to isolate peptides from the bursa fabricii and evaluate their immunotropic effect on mice of various lines with experimental immunodeficiency and the morphofunctional state of their immunopoiesis organs, i.e., thymus and spleen.

The research featured bursa fabricii hydrolysate and peptides, as well as thymus and spleen of male mice. Amine nitrogen was determined according to State Standard R 55479-2013; molecular weight of peptides was determined by gel electrophoresis. The morphometry of the thymus and spleen was calculated using VideoTesT-Morphology 5.0.

The research revealed the rational modes of enzymatic hydrolysis of the bursa fabricii protein by papain with subsequent isolation of peptides by ultrafiltration. According to the content of amine nitrogen in the bursa fabricii hydrolysate, the rational concentration of the papain enzyme was 0.15%. The molecular weight of peptides after ultrafiltration of bursa fabricii hydrolysate through membranes with a 43 kDa permeability had different values and depended on the concentration of papain, hydrolysis time, and temperature. The maximal amount of 27–18 kDa peptides was isolated at 36°C (85%) when the concentration of papain was 0.15% (73%), the hydromodule was 1:3 (78%), and the hydrolysis time of the raw material was 6 h (82%). The rational technological parameters of the hydrolysis of the bursa fabricii protein were as follows: concentration of papain – 0.15%, temperature – 36°C, hydromodule – 1:3, and hydrolysis time – 6 h. In immunodeficient mice, bursal peptides prevented a decrease in total cellularity in the thymus, sustained the content of CD3+ cells, activated the maturation of T-lymphocytes and proliferation of B-lymphocytes, and reduced the immunocytotoxic effects of cyclophosphamide.

The article offers a new technology for obtaining peptides with a pronounced immunotropic effect that can be used in functional food production.
Porous activated carbons derived from bamboo pulp black liquor for effective adsorption removal of tetracycline hydrochloride and malachite green from water
Authors: Yang Mengyuan , Cui Ce , Liu Li , Dai Lanling , Bai Wenhao , Zhai Jianyu , Jiang Shan , Wang Weijie , Ren Erhui , Cheng Cheng , Guo Ronghui
Published: July 2022

As a kind of wastewater produced by papermaking industry, bamboo pulp black liquor (BPBL) discharged into water causes serious environmental problems. In this work, BPBL was successfully converted into porous carbon after activation with potassium hydroxide (KOH) through one-step carbonization, and adsorption properties of porous carbon derived from bamboo pulp black liquor (BLPC) for tetracycline hydrochloride (TCH) and malachite green (MG) were studied. The adsorption capacities of BLPC for TCH and MG are 1047 and 1277 mg/g, respectively, due to its large specific surface area of 1859.08 m2/g. Kinetics and isotherm data are well fitted to the pseudo-second-order rate model and Langmuir model, respectively. Adsorption experiments and characterizations reveal that the adsorption mechanism involved in TCH and MG adsorption on BLPC mainly depends on the synergistic effect of pore filling, H-bonding, π-π interactions and weak electrostatic interactions. In addition, BLPC shows excellent photothermal properties, and the adsorption capacity of TCH and MG on BLPC can reach 584 and 847 mg/g under the irradiation of near infrared lamp for 50 min, respectively. The synthesized BLPC with high adsorption efficiency, good recovery ability, improved adsorption under near-infrared irradiation can be a promising and effective adsorbent for TCH or MG or other pollutes.
A relação entre a aderência dos relatos integrados ao framework do IIRC e o desempenho econômico
Authors: Romão Gabriel , Ribeiro Cíntia de Melo de Albuquerque , Neto Julio Vieira
Published: July 2022

Objetivo: Analisar a aderência dos Relatos Integrados (RIs) de uma amostra composta por três empresas brasileiras ao Framework do IIRC (International Integrated Reporting Council) e compreender a contribuição do nível de qualidade desses relatórios para o desempenho econômico das empresas adotantes.
Metodologia: As empresas foram selecionadas no banco de dados do IIRC. Utilizando como referência o método apresentado por Kiliç e Kuzey (2018), foi adaptado um modelo de ID (Índice de Divulgação), através da técnica de análise de conteúdo, para mensurar o nível de aderência dos Relatos ao Framework.  Após o cálculo dos IDs, foram analisados o Coeficiente de Variação (CV) de índices de liquidez e solvência das empresas e o desempenho macroeconômico do período pesquisado, objetivando constatar se os RIs aderentes ao Framework estão associados ao desempenho econômico das empresas.
Resultados: Os resultados da análise apontam que não é possível afirmar que elevados níveis de aderência ao Framework estão associados ao desempenho econômico das empresas, haja vista que o cálculo do CV dos índices financeiros, durante o período de publicações dos RIs, não apresenta uma dispersão menor quando comparados ao período anterior a tais publicações
Contribuição do estudo: As pesquisas recentes a respeito do tema Relato Integrado não apresentam uma relação entre a aderência das publicações ao Framework do IIRC e o desempenho econômico de empresas brasileiras. Desse modo, este estudo demonstra-se relevante ao pesquisar o conteúdo dos Relatos Integrados publicados por empresas brasileiras e o relacionamento dessas informações com o desempenho econômico, verificando se os Relatos Integrados cumprem a promessa de entregar benefícios econômicos aos adotantes do modelo.
Role of Drug Delivery System in Improving the Bioavailability of Resveratrol
Authors: Saleem Zonish , Rehman Kanwal , Hamid Akash Muhammad Sajid
Published: July 2022

Resveratrol (RSV) is known as a natural polyphenolic compound that is known for its therapeutic activities but has limited bioavailability. The aim of our study was to explore various drug-delivering methods that are being employed to achieve target-oriented delivery and therapeutic performance of RSV. To improve the bioavailability and pharmacokinetic properties of RSV, efforts are being made by producing efficient formulations accompanying efficient drug delivery strategies. Several clinical trial studies have been conducted on RSV isomers, and the majority of studies indicated that trans-RSV had better clinical potential and therapeutic effectiveness in various types of complications such as colorectal cancer, metabolic syndrome, hypertension, obesity, neurodegenerative diseases, diabetes, hepatic disease, cardiac disorders, and breast cancer. However, multiple research studies enable us to understand various strategies that can enhance the systemic availability and efficacy of topical RSV formulations. In this article, we emphasize the hurdles of RSV delivery processes. We summarized that for delivering liquid and solid microparticles of RSV, the micro-particulate system works efficiently. Another technique in which particles are enclosed by a coating is called microencapsulation. This technique reduces the degradation of pharmaceutical compounds. Similarly, the cyclodextrin system is mainly used for poorly soluble drugs. On the other hand, the vesicular system is another micro-particulate system that can encapsulate hydrophilic and hydrophobic drugs. However, the RSV nanosponge formulations have advanced nanodrug delivery systems also make it possible to use RSV for its antioxidant potential.
Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives
Authors: Lai Xixi , Najafi Masoud
Published: July 2022

Lung toxicity is a key limiting factor for cancer therapy, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy may also induce lung pneumonitis and fibro-sis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water mole-cules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells and some nonimmune cells such as fi-broblasts and endothelial cells. There are several ROS generating enzymes within lung tissue. NADPH Oxidase enzymes, cyclooxygenase-2 (COX-2), dual oxidases (DUOX1 and DUOX2), and the cellular respiratory system in the mitochondria are the main sources of ROS production follow-ing exposure of the lung to anticancer agents. Furthermore, inducible nitric oxide synthase (iNOS) has a key role in the generation of NO following radiotherapy or chemotherapy. Continuous genera-tion of ROS and NO by endothelial cells, fibroblasts, macrophages, and lymphocytes causes apop-tosis, necrosis, and senescence, which lead to the release of inflammatory and pro-fibrosis cyto-kines. This review discusses the cellular and molecular mechanisms of redox-induced lung injury following cancer therapy and proposes some targets and perspectives to alleviate lung toxicity.
Maternal and Placental Risk Factors for Small Gestational Age and Fetal
Malnutrition
Authors: Natarajan Vivekanand , Singh Poonam , Vigneshwar Nattankali Kannappa Venkatesan , Anthony Michael Leonard , Rao Shalinee , Chacham Swathi , Chaturvedi Jaya , Basu Sriparna
Published: July 2022

Aim:

This case-control study was conducted to identify maternal and placental risk fac-tors of small-for-gestational-age (SGA) and fetal malnutrition.

Methods:

Cases comprised 104 consecutively delivered SGA neonates (determined as per INTER-GROWTH-21st standard). An equal number of next-born gestation and gender-matched appropriate-for-gestational age (AGA) neonates served as controls. Maternal risk factors were enquired, and placentae were evaluated by clinical and histopathological examination. Nutrition of the neonates was assessed by the clinical assessment of nutrition (CAN) score. Univariate and multivariate lo-gistic regression analysis was done to identify the maternal and placental risk factors.

Results:

The prevalence of SGA in the present study was 23.9%. Maternal fever [adjusted Odds Ra-tio (aOR), 95% confidence interval (CI), 16.3 (3.5-124.1); p = 0.001], presence of placental syncyt-ial knots [aOR (95% CI), 2.9 (1.1-9.1); p = 0.04] and placental calcifications [aOR (95% CI), 3(1.1-8.7); p = 0.03], were identified as independent predictors of SGA using multivariate logistic regres-sion analysis. Malnutrition (SCORE <25) affected 64% of SGA and 16.3% of AGA neonates. The only risk factor significantly associated with malnourished SGA was prematurity, whereas malnour-ished AGA was significantly associated with prematurity and fetal distress. In-hospital morbidities significantly higher in SGA were perinatal asphyxia, respiratory distress, need for respiratory sup-port, polycythemia, hypoglycemia, and feeding intolerance. Mortality before discharge was 4.8% and 3.8% in SGA and AGA population, respectively (p > 0.05). Neonatal outcomes were compara-ble among well-nourished, malnourished SGA and AGA groups.

Conclusions:

Maternal fever, placental syncytial knots, and calcifications were independent risk fac-tors of SGA, whereas prematurity and fetal distress were responsible for malnutrition.
WITHDRAWN: Bioactive Thiazole, Coumarin and Benzothiazole Heterocyclics
and their Biological Applications: A Brief Appraisal
Authors: Singh Dilpreet , Gupta Sakshi , Razdan Karan , Tiwari Prashant
Published: July 2022

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

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A Mini-Review on Simultaneous Quantification of Active Pharmaceutical Ingredients By UV and Quality by Design Assisted HPLC Method
Authors: Rajput Geeta , Patel Preeti , Gupta Ghanshyam Das , Kurmi Balak Das
Published: July 2022

Objective:

Nowadays, most pharmaceutical formulations contain more than one drug because
there are numerous advantages to multicomponent formulations, like patient compliance, enhanced efficacy,
synergetic effects of both drugs, etc. This review paper describes the simultaneous estimation methods
such as UV spectroscopy and high-performance liquid chromatography (HPLC) to determine various
drug molecules and active pharmaceutical ingredients (APIs). In addition, the implementation of the quality
by design (QbD) principle is used to illustrate how these approaches can be developed and validated.

Method:

To estimate the drug content in these multicomponent formulations, several UV spectroscopy
and HPLC methods have been developed and validated as per the available literature. UV spectrophotometry
and HPLC are among the most critical tools in the analysis of drugs in pharmaceutical formulations.
The QbD based optimization approach applies to developing the simultaneous estimation method, which
could be designed with predefined objectives, that emphasize the product and process to maintain the
desired quality. The QbD approach followed the guidelines mentioned in ICH Q8 (R2).

Results:

This review article gives brief information regarding the various QbD optimized UV and HPLC
methods for simultaneous estimation of multicomponent formulations and their recent applications and
elaborates on multiple steps in the development of the HPLC method along with their applications.

Conclusion:

The available information is very informative for multicomponent analysis, and it will open
new paradigms in upcoming research in the field of analysis.
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways
Authors: Singh Jyoti , Luqman Suaib , Meena Abha
Published: July 2022

Background:

Carvacrol is a naturally occurring phenolic isopropyl monoterpene isolated from oregano, thyme, pepperwort, ajwain, marjoram, and wild bergamot. It possesses pharmacological activities, including anticancer, anti-genotoxic, and anti-inflammation associated with antioxidant properties. The antioxidant property of carvacrol is found to be accountable for its anticancer property. Thus, the present review summarizes and discusses the anticancer potential of carvacrol, revealing its target, signalling pathways, efficacy, pharmacokinetics, and toxicity.

Objective:

Carvacrol showed promising activity to be considered in more detail for cancer treatment. This review aimed to summarize the evidence concerning understanding the anticancer potential of carvacrol. However, the mode of action of carvacrol is not yet fully explored and hence requires detailed exploratory studies. This review consists of carvacol’s in vitro, in vivo, preclinical and clinical studies.

Method:

A literature search was done by searching various online databases like Pubmed, Scopus, and Google Scholar with the specific keyword “Carvacrol,” along with other keywords such as “Antioxidant properties,” “oncology research,” “genotoxicity,” and “anti-inflammatory property.”

Results:

Carvacrol possesses weak mutagenic and genotoxic potential at nontoxic doses. Carvacrol alone shows the potential to target cancerous cells and significantly deter the growth of cancer cells; this is a targeted method. It offers anti-inflammatory effects by decreasing oxidative stress, which primarily targets ER and mitochondria. Carvacrol depicts targeted explicitly ROS-dependent and mitochondrial-mediated apoptosis in different cancer cells. Moreover, carvacrol significantly regulates the cell cycle and prevents tumor progression. Few reports also suggest its a significant role in inhibiting cell migration, invasion, and angiogenesis in tumor cells. Hence, carvacrol affects cell survival and cell-killing activity by targeting key biomarkers and major signalling pathways, including PI3K/AKT/mTOR, MAPK, STAT3, and Notch.

Conclusion:

Until now, its anticancer mechanism is not yet fully explored. A limited number of research studies have been done on carvacrol instead of possessing promising anti-cancer potential. It possesses both cancer prevention and cancer therapeutic properties. This molecule needs more validatory research so that it could be analyzed precisely and sensibly
The Effect of Skin-to-Skin Contact Between Father and Baby on Paternal Attachment
Authors: Korukcu Oznur , Yilmaz Mine Erdoğan , Kabukcuoglu Kamile
Published: July 2022

Aim:

This study aims to determine the effect of skin-to-skin contact between father and baby within the first three hours following the childbirth on the level of paternal attachment.

Methods:

Data were collected from 69 fathers between May-July 2018 with Paternal Infant Attachment Scale in Antalya Medical Park Hospital in Turkey in this quasi-experimental study.

Results:

Total score of the fathers who established skin-to-skin contact with the babies was 82.34±7.76, and that of the control group was 66.07±18.2 (p<0.05). Moreover, the paternal-infant attachment level of the fathers in the study group who became fathers for the first time was higher than that of the control group.

Conclusion:

The skin-to-skin contact between father and baby following childbirth was an effective practice in the transition to fatherhood.
Green Sukuk Investment: Student's Role And Interest In Realizing A Golden Indonesia 2045
Authors:   Universitas Negeri Malang, Masruro Umi
Published: July 2022

Green sukuk is an environmentally sound investment, this investment was first issued in November 2019 with serial number ST006. Furthermore, green sukuk reopened in November 2020 with serial number ST007. Through the issuance of green sukuk, the government can finance green projects to reduce climate change, such as reducing greenhouse gases. The research method used is a qualitative method. The purpose of this study is to determine the role of green sukuk in realizing Indonesia gold in 2045. The subjects of this study are students who are less aware of the existence of green sukuk and investors who have participated in green sukuk. Through this research, it will be known the role of green sukuk in realizing Indonesia gold in 2045. The results of this research are that not many people know about the presence of green sukuk so it needs to be studied more deeply. Students who have no/little income cannot participate in green sukuk investment. For that students need to plan capital for the next few years to invest. Thus, students as part of society are ready to contribute through green sukuk to realize Golden Indonesia 2045 with all the potential that exists.
RECORDS OF PREDATORS AND PARASITES (VERTEBRATES AND INVERTEBRATES) OF CREOSOTE BUSH GRASSHOPPER BOOTETTIX ARGENTATUS BRUNER, 1889, (ORTHOPTERA: ACRIDIDAE: GOMPHOCERINAE) FROM THE BOLSÓN DE MAPIMI, DGO. (CHIHUAHUAN DESERT), MEXICO
Authors: Rivera García Eduardo
Published: July 2022

This paper summarizes unpublished information and isolated field observation records on the principal predators (9 vertebrates, 10 insect and 2 orb weaver and a terrestrial spider species) and parasites (an insect and one mite species) of B. argentatus a non economic, highly specialized monophagous grasshopper species of creosote bushes Larrea tridentata in Mapimi Biosphere Reserve, a southern region of the Chihuahuan Desert.
Спектральные характеристики свечения пламен каменных углей во время воздействия лазерных импульсов
Authors: Адуев Б.П. , Нурмухаметов Д.Р. , Крафт Я.В. , Исмагилов З.P.
Published: July 2022

The results of measuring the characteristics of the glow of coal flames at the initial moments of ignition under the action of laser pulses of a neodymium laser (1064 nm, 120 µs) are presented. In microparticles of coal grades DG, G, Zh, and K, when the corresponding critical energy densities are exceeded during a laser pulse, the surface ignites and flame propagates at a speed of V ≈ 50 m/s. The emission spectra of flames are contributed by the emission of emitted hot coal particles, excited H∗2 and H2O∗ molecules, as well as the flame emission arising from the oxidation of carbon (CO∗) and carbon monoxide (CO∗2) by atmospheric oxygen
Homogeneous {Ti2Ni} Heterotrinuclear Catalyst for Ethylene Polymerization and Copolymerization
Authors:   Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Cidade Universitária – Centro de Tecnologia – Bloco J. POBox 68525. Rio de Janeiro – RJ, 21945-970, Brazil, Rocha Luiz Felipe da M. , Ferreira Leonardo C. ,   Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Cidade Universitária – Centro de Tecnologia – Bloco J. POBox 68525. Rio de Janeiro – RJ, 21945-970, Brazil, Marques Maria de Fátima V. ,   Instituto de Macromoléculas Professora Eloisa Mano, Universidade Federal do Rio de Janeiro, Cidade Universitária – Centro de Tecnologia – Bloco J. POBox 68525. Rio de Janeiro – RJ, 21945-970, Brazil, Bitzer Rodrigo S. ,   Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária – Centro de Tecnologia – Bloco A. Rio de Janeiro – RJ, 21941-909, Brazil, Nascimento Marco Antonio Chaer ,   Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária – Centro de Tecnologia – Bloco A. Rio de Janeiro – RJ, 21941-909, Brazil
Published: July 2022

We synthesized and spectroscopically characterized a new heterotrimetallic {Ti2Ni} ethylene (co)polymerization precatalyst containing one (α-diimine)NiBr2 and two (phenoxy-imine)TiCl4 scaffolds. Its calculated structure was investigated at the DFT B3LYP/LACVP** level. Our calculations showed that the titanium(IV) centers were in a slightly distorted trigonal bipyramidal environment, and the average Ti···Ni distance was 8.76 Å. The precatalyst was used for synthesizing polyethylene and ethylene copolymers. The results of GPC analyses showed that the obtained polyethylenes had the desired bimodal molecular weight distributions. The FTIR spectra revealed that polydispersity decreased as the vinyl end-group content increased. These results suggested that high mechanical resistance can increase the mechanical energy needed for processing the material. All 13C NMR signals were assigned to short-chain branches with specific spatial arrangements along the polymer backbone. The chain walking mechanism of branch formation controls the spacing and conformational arrangements between these short chains.
Psychological Distress due to COVID-19 in the Albanian Adult Population
Authors:   Faculty of Technical Medical Sciences, University of Medicine Tirana, Albania, Ndreu Vjollca , Themeli Yllka ,   Faculty of Technical Medical Sciences, University of Medicine Tirana, Albania, Zekja Ilirjana ,   Faculty of Technical Medical Sciences, University of Medicine Tirana, Albania, Kamberi Fatjona ,   Research Centre of Public Health, Faculty of Health, University of Vlore “Ismail Qemali”, Vlore, Albania
Published: July 2022

The World Health Organization declared the COVID-19 pandemic on March 11th, 2020. The pandemic had significantly affected public health, and the mental health of people was compromised regardless of age or socioeconomic status. In this study, we measured the psychological distress caused by the pandemic and determined the associated factors. An online survey was conducted from November 16th (2020) to January 31st (2021). The participants were Albanian adults (≥18 years old). The call to participate was posted on social networks. A questionnaire based on the Generalized Anxiety Disorder (GAD-7) scale and Patient Health Questionnaire (PHQ-9) was distributed to the participants via Google Forms. The internal consistency of the scales was assessed using Cronbach’s alpha. The total number of participants was 488, and 87.3% were females. The mean age was 21.17 years. Full-time students and health care workers comprised 58% and 12.9% of the participants, respectively. The participants were asked 24 questions, and five factors explained 54.14% of the variance. The factors included mental fatigue, psychological consequences in metabolism, obsession with protective measures, negative perception of the situation, and empathy for patients with COVID-19. Effective and relevant mental health interventions and policies to help cope with psychological distress specifically related to COVID-19 should be designed and implemented.
Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile App
Authors: Shaker Jake , Buono Frank , Lalloo Chitra , Stinson Jennifer , Grau Lauretta , Zempsky William , Larkin Kaitlyn
Published: July 2022

Background

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic condition affecting 1 in 2500 individuals. Over 50% of individuals with NF1 report significant pain and discomfort, which may be associated with benign and malignant tumors, but is often not localized to a structural lesion, thus presenting treatment challenges for patients and their medical caregivers. To date, there are very few treatments aside from surgical intervention to mitigate pain.

Objective

We developed the iCanCope-NF mobile app for pain self-management. iCanCope-NF is a customized self-monitoring and pain management mobile app designed to provide resources and support for those having chronic pain due to NF1. The app enables users to access daily pain monitoring and quality of life check-ins, allows them to plot interrelated variables on various timelines to observe trends in pain and interference across different areas of life (such as sleep, physical activity, and mood), and provides them with the option to set physiological and psychological goals as well as a robust library of written and video resources to help manage pain symptoms and to better cope with NF1.

Methods

This paper evaluated the iCanCope-NF to reduce pain severity and interference in adults with NF1. A total of 80 participants across 3 different groups (control, iCanCope-NF access condition, and iCanCope-NF contingency management condition where subjects were provided monetary incentives for engaging with the various features within the app [CM]) completed a randomized clinical trial in which evaluations were completed at intake (initial day of participation), discharge (2 months after intake), and 6 weeks after discharge.

Results

Preliminary data analysis demonstrated individuals randomized to the iCanCope-NF + CM had greater engagement with the mobile app than individuals who were randomized to iCanCope-NF. Additionally, individuals in the iCanCope-NF + CM consistently checked in more (SD 59.5/60 days) than individuals in the iCanCope-NF group (SD 51/60 days). Pain interference, as measured by the Pain Interference Index (PII), was significantly different across all 3 groups at discharge: control (M=6.3), iCanCope (M=5.7), iCanCope + CM (M=5.1), P<.05.

Conclusions

Qualitative interviews completed at discharge for individuals with access to the app indicated that the app was a “wonderful measuring tool” and “provided credibility of my pain symptoms,” and that it was a dramatic and distinctive aide in the monitoring and tracking of their pain symptoms. We demonstrated preliminary acceptability and efficacy for iCanCope-NF as the first pain self-management tool for individuals with NF1. iCanCope-NF + CM was successful in increasing engagement and decreasing pain interference.

Trial Registration

ClinicalTrials.gov NCT04561765; https://clinicaltrials.gov/ct2/show/NCT04561765

Conflicts of Interest

None declared.
A Sociotechnical Model for Managing Mental Health Distress Among College Students During and After a Pandemic: Development and Usability Study
Authors: Tabisula Braden , Uwaoma Chinazunwa
Published: July 2022

Background

Mental distress affects people's health in many ways and at different levels. However, anxiety and depressive disorder have significantly increased since the outbreak of the COVID-19 pandemic. Controlling the spread of COVID-19 resulted in isolation protocols such as stay-at-home orders, social distancing, and quarantining. Though well intended, the protocols exacerbated the already increasing number of mental distress cases prior to the pandemic. During the rollout of these pandemic interventions to control the spread, there was a noticeable increase in technology use. For instance, to cope with their mental health concerns, several people, including students, turned to technology to sustain their connection to the society and to access mental health services. Although a plethora of technological tools exist for communication and socialization, it is unknown which types of technologies are effective in the management of anxiety and depression symptoms. Hence, there is a need for a sociotechnical model that can identify technologies effective in addressing an individual's mental health symptoms, specifically among college students.

Objective

The objective of this study is to identify the effectiveness of current technologies used in coping with a mental distress situation and to develop a model that college students can use to effectively handle their mental health distress during and after a pandemic.

Methods

The proposed model is built on the Stallman's Health Theory of Coping. The model expands the theory with 5 significant components, namely Mental Health Distress Situation, Level of Distress, Coping Strategy, Technology Used, and the Mental Health Distress Outcome. This paper describes the conceptualized functionality of each component. The model will be implemented as a prototype mobile app and evaluated using a case study with students from 2 colleges.

Results

The study is underway. However, the model will be evaluated using 2 categories of nonrandomized focus groups of college students to determine the usefulness and the effectiveness of the model. Each group will consist of 8 participants. Data collected from each group will be qualitatively evaluated to identify themes from the responses, which will be used to refine the model to meet the study objective.

Conclusions

Many people experienced an increase in mental distress due to the isolation requirements arising from the COVID-19 pandemic. With limited access to traditional coping strategies in public and large gatherings, people turned to technology to manage their stress, anxiety, and depression. However, there is no “one-size-fits-all” technology that can address every individual distress level and coping strategy. Thus, developing a model to identify effective technologies used as coping strategies will be helpful for an individual in alleviating their mental health distress symptoms during and after a pandemic.

Conflicts of Interest

None declared.
Adaptation of a Theory-Based, Clinic-Affiliated Smartphone App to Improve HIV Testing and Pre-exposure Prophylaxis Uptake Among Gay, Bisexual, and Other Men Who Have Sex With Men in Malaysia
Authors: Rosen Aviana O , Wickersham Jeffrey A , Altice Frederick L , Khati Antoine , Luces Jeffrey Ralph , Ni Zhao , Zhou Xin , Azwa Iskandar , Kamarulzaman Adeeba , Ab Halim Mohd Akbar , Shrestha Roman
Published: July 2022

Background

In Malaysia, HIV disproportionately affects gay, bisexual, and other men who have sex with men (GBMSM). Homosexuality and substance use are criminalized in Malaysia, making GBMSM bear multilevels of social stigma and discrimination, including in health care. Mobile health (mHealth), particularly smartphone apps, is a promising and cost-effective strategy for reaching stigmatized and hard-to-reach populations like GBMSM and linking them to HIV prevention services (eg, HIV testing and pre-exposure prophylaxis [PrEP]), particularly in the context of COVID-19.

Objective

This study aimed to adapt the HealthMindr app (Emory University), which was developed with GBMSM in the United States, to improve HIV testing and PrEP uptake for GBMSM in Malaysia.

Methods

We conducted online focus group discussions (FGDs) between August and September 2021 with 20 GBMSM and 16 community stakeholders (eg, doctors, nurses, pharmacists, and nongovernmental organization staff). Participants were asked questions regarding their preferences for functions and features in mHealth apps among GBMSM and suggestions for adapting the HealthMindr app to the Malaysian context. Each session was digitally recorded and transcribed. Transcripts were inductively coded using Dedoose software (University of California, Los Angeles) and analyzed to identify and interpret emerging themes.

Results

The FGDs with GBMSM revealed preferences for interfacing with apps to access HIV testing, PrEP, and counseling services. Stakeholders showed strong interest in using the app-based platform to deliver integrated care (eg, HIV and mental health). The key themes mostly focused on adaptation and refinement for the Malaysian context and were related to cultural and stylistic preferences (design and user interface), engagement strategies (reward systems, marketing campaigns, and reminders), and recommendations for new functions (enhanced communication options via chat and discussion forums) in a one-stop hub for all HIV prevention needs (HIV self-testing, PrEP, and postexposure prophylaxis) that minimize privacy and confidentiality risks.

Conclusions

Our data suggest that a tailored HIV-prevention app would be acceptable for GBMSM in Malaysia. The findings provided detailed recommendations for the successful adaptation and refinement of the existing platform for optimal use in the Malaysian context.

Conflicts of Interest

None declared.
A Sociotechnical Model for Managing Mental Health Distress Among College Students During and After a Pandemic: Development and Usability Study (Preprint)
Authors: Tabisula Braden , Uwaoma Chinazunwa
Published: July 2022

BACKGROUND

Mental distress affects people's health in many ways and at different levels. However, anxiety and depressive disorder have significantly increased since the outbreak of the COVID-19 pandemic. Controlling the spread of COVID-19 resulted in isolation protocols such as stay-at-home orders, social distancing, and quarantining. Though well intended, the protocols exacerbated the already increasing number of mental distress cases prior to the pandemic. During the rollout of these pandemic interventions to control the spread, there was a noticeable increase in technology use. For instance, to cope with their mental health concerns, several people, including students, turned to technology to sustain their connection to the society and to access mental health services. Although a plethora of technological tools exist for communication and socialization, it is unknown which types of technologies are effective in the management of anxiety and depression symptoms. Hence, there is a need for a sociotechnical model that can identify technologies effective in addressing an individual's mental health symptoms, specifically among college students.

OBJECTIVE

The objective of this study is to identify the effectiveness of current technologies used in coping with a mental distress situation and to develop a model that college students can use to effectively handle their mental health distress during and after a pandemic.

METHODS

The proposed model is built on the Stallman's Health Theory of Coping. The model expands the theory with 5 significant components, namely Mental Health Distress Situation, Level of Distress, Coping Strategy, Technology Used, and the Mental Health Distress Outcome. This paper describes the conceptualized functionality of each component. The model will be implemented as a prototype mobile app and evaluated using a case study with students from 2 colleges.

RESULTS

The study is underway. However, the model will be evaluated using 2 categories of nonrandomized focus groups of college students to determine the usefulness and the effectiveness of the model. Each group will consist of 8 participants. Data collected from each group will be qualitatively evaluated to identify themes from the responses, which will be used to refine the model to meet the study objective.

CONCLUSIONS

Many people experienced an increase in mental distress due to the isolation requirements arising from the COVID-19 pandemic. With limited access to traditional coping strategies in public and large gatherings, people turned to technology to manage their stress, anxiety, and depression. However, there is no “one-size-fits-all” technology that can address every individual distress level and coping strategy. Thus, developing a model to identify effective technologies used as coping strategies will be helpful for an individual in alleviating their mental health distress symptoms during and after a pandemic.
Populisme: Konsekuensi dari Stagnasi Politik dan Demokrasi di Indonesia
Authors: Nur Budiman Bachtiar , Dewi Safitri Bella , Rizki Putriga Balilah , Julietta Imanuella Wicaksono Vinona
Published: July 2022

Suasana menjelang pemilihan umum 2024 telah dapat dirasakan dalam dinamika politik Indonesia. Salah satu fenomena yang kerap kali mewarnai jalannya pemilihan umum di Indonesia adalah keberadaan kandidat populis yang memanfaatkan narasi-narasi politik identitas untuk mengangkat namanya dalam ajang pemilihan. Artikel ini mencoba untuk menganalisa keberadaan populisme sebagai konsekuensi dari stagnasi politik dan kurangnya pengawasan terhadap demokrasi di Indonesia. Dampak buruk dari populisme pernah terjadi di Amerika Serikat. Negara dengan demokrasi yang matang tersebut masih saja mudah terpecah akibat gaya kepemimpinan populis mantan presiden Donald Trump yang berakhir dengan penyerangan dan vandalisme di Gedung Capitol. Penulis berargumen bahwa Indonesia dengan segala kemajemukan identitas dan multikulturalismenya, ditambah dengan demokrasi yang belum mapan, sangat mudah untuk dipecah-belah melalui narasi kebencian dan politik identitas. Pemilihan umum 2024 berpotensi besar untuk kembali memunculkan kandidat populis yang lebih banyak, mengingat berbagai lembaga survei akuntabilitas calon presiden telah mengantongi sejumlah nama yang potensial untuk memainkan manuver politik yang serupa, seperti Prabowo Subianto, Anies Baswedan, dan Ganjar Pranowo. Artikel ini menggunakan kajian literatur untuk mengumpulkan data dan membahas permasalahan ini. Terakhir, Penulis berharap tulisan ini dapat menambah pengetahuan dan kesadaran pembaca mengenai dinamika politik nasional.
A New Phase in the History of Education for Sustainability. The Emergence of Territorial Education in a Post-Covid Recovery Period
Authors: Simon Sandrine
Published: July 2022

The current pandemic has acted as a catalyst for chain reactions on issues such as the decline of certain industries, job losses and problems of food transportation. In a “globalized world”, connections require re-organizing. More than ever, the economic, environmental and social un-sustainability of our cities is exacerbated. Education for sustainability could help societies to address such vulnerabilities and recover from the pandemic. With a focus on cities, this article explores the emergence of “Territorial Learning” (TE). It illustrates the importance of taking the (geographical, cultural and socio-economic) context into account when contributing to education for sustainability as well as the operationalization of this concept and the identification of strategic priorities, participants in the learning process, and skills needed to ensure that learning outcomes lead to actions that will facilitate the transition to more resilient societies. The article explains the recent emergence of TE and its links with education for sustainability and global citizenship. It then illustrates how TE can help in dealing with two urban priority issues (food security and urban governance) and develop skills for sustainability. Finally it suggests some areas for future research, if TE is to help with the recovery of post-pandemic cities.
Evaluierung der Kooperation im Bereich der IÖB zwischen BMDW, BMK und BBG. Synthesebericht
Authors:   IWI - Industriewissenschaftliches Institut, Brunner Philipp , Demirol Daran , Nikias Dick , Pistelka Marion , Pöchhacker-Tröscher Gerline , Schneider Herwig W. , Wagner Karin
Published: July 2022

Die Innovationsfördernde Öffentliche Beschaffung (IÖB) als nachfrageseitiges Instrument der Innovationspolitik soll Innovationsimpulse im heimischen Wirtschaftsstandort auslösen. Seit 2019 obliegt die Umsetzung des IÖB-Leitkonzepts einer öffentlich-öffentlichen Kooperation (ÖÖK) zwischen BMK, BMDW sowie BBG, deren Aufgabenerfüllung insbesondere durch das Serviceangebot der IÖB-Servicestelle erfolgt. Der Fokus der gegenständlichen Evaluierung liegt insbesondere auf den die Kooperation umfassenden Tätigkeiten aller Kooperationspartner:innen sowie der operativen Abwicklung im Beobachtungszeitraum April 2019 bis Jänner 2022. Dies umfasst dabei insbesondere: • eine Beurteilung der Aufgabenerfüllung der Kooperationspartner und deren Zusammenspiel • eine Beurteilung der administrativen Abwicklung der Kooperation (inkl. Berichtswesen, budgetäre Ausstattung, Controlling, Risikomanagement, Kennzahlen etc.) • eine Beurteilung der Zweckmäßigkeit und Effizienz der Governance-Mechanismen • eine Überprüfung der Wirkung ausgewählter Leistungen der IÖB-Servicestelle Das eingesetzte Methodenspektrum umfasst einen Mix aus quantitativen und qualitativen Erhebungselementen.
ТЕХНОЛОГИЯ СЕТЕВОГО ПОЗИЦИОНИРОВАНИЯ LTE. Часть 1. Архитектура
Authors: Фокин Г. , Григорьев В. , Авдонин И.
Published: July 2022

На сегодняшний день технологии сетевого позиционирования партнерского проекта 3GPP, использующие инфраструктуру сетей подвижной радиосвязи, наиболее широко внедрены в сетях стандарта 4G/LTE и обеспечивают точность определения местоположения пользовательских устройств (UE) в десятки метров. На порядок более высокая точность
позиционирования в сетях 5GNR, с точки зрения народного хозяйства, является предметом среднесрочной и долгосрочной перспективы. Актуальность технических решений по определению местоположения UE в развернутых сетях 4G/LTE обусловлена невозможностью уверенного приема сигналов глобальных навигационных спутниковых систем в сценариях
плотной городской застройки. В первой части исследования, посвященного технологиям сетевого позиционирования 4G, формализована архитектура системы определения местоположения пользовательских устройств с использованием инфраструктуры сетей подвижной радиосвязи LTE.
Obstacle Detection in Self-Controlled Cars
Authors: Patidar Shivangi
Published: July 2022

Abstract: An autonomous car is a vehicle that can guide itself without human command and control. It is also known as a driverless car, self-driving car, unmanned vehicle, or robot car. Autonomous vehicles can perceive their surroundings (obstacles and track) and commute to their destination with the help of a combination of sensors, cameras, and radars. There is a basic need for a system that can detect obstacles and move in a pre-computed path, a system that can detect the obstacles that appear suddenly which may cause accidents. Therefore, the automatic obstacle avoidance vehicle is designed for obstacle detection and collision avoidance. The ultrasonic sensor is tuned to enable the real-time obstacle avoidance system for wheeled robots, allowing the robot to continuously sense its environment, avoid obstacles and move to its target area. The design requires an ultrasonic sensor (hcsr04) to detect the obstacle and determine its distance. This sensor module is placed on the front of the vehicle and mounted on a servo motor rotating in the direction of the sensor. The system includes a motor driving module and four dc wheel motors which are used to move the vehicle forward, reverse, left, right, and stop. The Arduino Uno microcontroller is mainly used to control the vehicle and achieve the desired detection and prevention
Understanding the importance of ecotourism by supporting eco-design principles
Authors: Parakh Neel Mahendra
Published: July 2022

Abstract: Ecotourism is a form of tourism which involves delicate and relatively undisturbed natural areas, intended as a smallscale alternative to standard mass tourism. A walk through the forest or trail is not ecotourism unless that particular walk benefits that environment and the people who are involved. Ecotourism can be termed as ‘responsible tourism’ and ‘green tourism’, which focuses upon the responsibility of nature and its green development.[1] This paper studies the concept of eco-tourism and its various aspects which also involves eco-friendly materials. Its purpose is to educate the travellers, to provide funds for ecological conservation, to directly benefit the economic development. The results show that there is a need for eco-design and use of eco-friendly approach, which demands continuous efforts on Tourism Ministry state government, host community and tourists to support and promote Eco-tourism. The purpose of this study is to look at ways in which ecotourism and sustainable development can be evaluated and suggest ways to improve current ecotourism practices. Ecotourism definitions require that the indigenous host community receives the benefits and despite its small-scale and seasonal character, it has the potential to deliver economic benefits on multiple levels
Prediction of Mental Health (Depression) Using Data Science Technique
Authors: K Yuvasri
Published: July 2022

Abstract: Early diagnosis of mental health problems helps the professionals to treat it at an earlier stage and improves the patients quality of life. Depression is one of the leading causes of disability worldwide. This article provides an overview of AI and current applications in healthcare, a review of recent original research on AI specific to mental health, and a discussion of how AI can supplement clinical practice while considering its current limitations, areas needing additional research, and ethical implications regarding AI technology. So, there is an urgent need to treat basic mental health problems that prevail among children which may lead to complicated problems, if not treated at an early stage. Machine learning Techniques are currently well suited for analyzing medical data and diagnosing the problem. The attributes have been reduced by applying Feature Selection algorithms over the full attribute data set. The accuracy over the full attribute set and selected attribute set on various machine learning algorithms have been compared. However, caution is necessary in order to avoid over-interpreting preliminary results, and more work is required to bridge the gap between AI in mental health research and clinical care