bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomechanical Investigation about Traditional and Cortical Trajectory Screws of Static and Dynamic Lumbar Fixation
Authors: Liu Che-Wei , Wang Lu-Lin , Xu Yu-Kun , Chen Chun-Ming , Wang Jian-Cyuan , Tsai Wei-Tsung , Lin Shang-Chih
Published: November 2019

Background To evaluate kinetic and kinematic behavior in both static and dynamic CBT fixation a finite element study was designed. Two types of screw trajectories are commonly used in lumbar surgery. Both traditional trajectory (TT) and cortical bone trajectory (CBT) provide equivalent pull-out strengths of a screw. Dynesys fixation of TT screws, but not dynamization of CBT screws, has been used extensively in lumbar surgery. This study aimed to simulate the biomechanics of CBT-based dynamic system for an evaluation of CBT dynamization.Methods A validated nonlinearly lumbosacral finite-element model was used to simulate four variations of screw fixation. Responses of both implant (screw stress) and tissues (disc motion, disc stress, and facet force) at the upper adjacent (L3-L4) and fixed (L4-L5) segments were used as the evaluation indices. Flexion, extension, bending, and rotation of both TT and CBT screws were simulated in this study for comparison.Results The results showed that the TT static was the most effective stabilizer to the L4-L5 segment, followed by CBT static, TT dynamic, and the CBT dynamic, which was the least effective. Dynamization of the TT and CBT fixators decreased stability of the fixed segment and alleviate adjacent segment stress compensation. The 3.5-mm diameter CBT screw deteriorated stress distribution and rendered it vulnerable to bone-screw loosening and fatigue cracking.Conclusions A systematic analysis of the effects of TT and CBT fixation constructs on kinematic and kinetic responses in a full lumbosacral model is currently lacking. This study examined both the static fixation effect and its dynamic counterpart and identified that dynamization of CBT have slightly inferior structural stiffness than dynamic TT and cautious preoperative evaluation is essential if 3.5-mm diameter CBT screws are used. Therefore, 4.5-mm or 5.5-mm diameter CBT screws, or as big as tolerated, are recommended to avoid loosening and cracking.
Concept Analysis of Community Health Outreach: a systematic review
Authors: Shin Hye Young , Kim Ka Young , Kang Purum
Published: November 2019

Background: The definition of community health outreach to promote the health of vulnerable populations depends heavily on the particulars of the given health project and community. There is no consistency in the meanings attached to the concept itself. Our study aimed to clarify the general definition of community health outreach in order to facilitate its understanding and use. Methods: We used Walker and Avant’s method to conduct the concept analysis of community health outreach. We searched texts on PubMed, Scopus, and CINAHL databases published from 2010 to 2018 and included a total of 38 articles in our analysis. We used Walker and Avant’s method to conduct the concept analysis of community health outreach. Results: The defining attributes of the concept of community health outreach were purposive intervention, temporary, mobile, collaboration with the community, and sponsorship. The antecedents were populations at health risk and awareness of health risks. The consequences were increased accessibility and health promotion. Conclusion: This study proposed the definition of community health outreach that a sponsored, temporary, mobile project that collaborates with a community to undertake its purposeful health intervention to reach the population at health risk. Therefore, the definition will provide a general understanding of the outreach undertaken by health workers so that health professionals and community residents can better connect.
Transport Economics and Sustainable Development in Ukraine
Authors: Hens Luc , Melnyk Leonid , Matsenko Oleksandr , Chygryn Olena , Gonzales Candy Chamorro
Published: November 2019

The contemporary development of transport systems is characterized by an ecological, technical, social and economic contradictions. An acceptable global solution can be obtained by matching relevant criteria. This paper provides a synthesis of economic and organizational peculiarities on sustainable development to transport internationally, it reviews recent trends in this respect and applies international trends to Ukraine. Authors concluded that environmental pollution effects connected with transport system’s development providing additional costs in different spheres of society that gives the opportunity to assert on necessity of integration the research outcomes on green mobility in applied activity. This article summarizes the implemented transport project examples and analyzed their role in realizing sustainable development principles. The authors proved that all creating programs and projects in transport should be based on such interconnected principles: transport planning and localization of production and consumption; transition to more environmentally efficient transport; improving the technology and fuel. In addition it was suggested to include the transport greening principles in criteria’s of economic efficiency in transport. The strategies to reorient the Ukrainian transport industry towards resource-saving approaches are formulated. Substantiated that applying energy-efficient approaches in transport will result in socio-ecological and economic benefits, including ecological, social, public health, transport and urban components. The authors analyzed advantages and disadvantages of different kind of modern transport vehicles in the context of sustainable development principles realization that allows understanding which economic sectors and entrepreneurs should be involved in the process of transport greening creating the basis for public, private and foreign investment attraction.
Keywords: transport system, sustainable development, transport greening promotion, effectiveness, benefits
Profit Management as an Instrument for SMEs Developing: the Case for Slovakia
Authors: Siekelova Anna , Kovacova Maria , Adamko Peter , Stehel Vojtech
Published: November 2019

The goal of the business should reflect its efforts to achieve a certain future state. Classical economic theories emphasize the achievement of profit as a fundamental goal of business. Modern theories consider gaining profit as one of the basic motivating factors. In practice, we distinguish several profit categories that are described in our contribution. The effort of businesses is detection of indicators that help enterprises to generate profit. In our contribution, we focused on the analysis of the profitability of small and medium-sized enterprises as well as on the identification of indicators that significantly influence the rate of profit. In our research we worked with a sample of 9,500 Slovak small and medium-sized enterprises. It was primarily a limited liability company with domestic ownership. We mainly focused on this type of businesses because many authors emphasize the irreplaceable role of small and medium-sized enterprises in countries' economies. Small and medium-sized enterprises play a very important role not only in Slovakia but also in the global economy. The significantly influence the creation of hundreds of jobs, regional development or a high percentage of GDP. Approximately 98% of enterprises in the Slovak Republic fall into the category of small and medium-sized enterprises. For their functioning, it is very important to have the capital that they inevitably need, either for the start of business as such, for development. However, these type of businesses does not always have easy access to financing, especially in the case of bank loan financing. Profit for SMEs is a very important internal source of funding. The aim of our paper is profit analysis and identification of the main profit-taking indicators. The analysis of the profitability was conducted by using methods of descriptive statistics. Based on the studied literature, we selected individual profit categories as basic indicators of profitability as well as selected indicators of profitability that are defined below. Pearson's correlation coefficient and the one-way ANOVA were used to examine the relationship between the selected indicators and achieved profit. Graphs and charts are used to clear the processing of the results of our research.
Keywords: ANOVA, cash management, earnings before interest and taxes, earnings before interest, taxes, depreciation and amortization, net operating profit after tax, earnings before interest after taxes, Pearson correlation coefficient.
INFORMATION TECHNOLOGY GOVERNANCE PERFORMANCE MEASUREMENT AT NATIONAL LIBRARY USING COBIT FRAMEWORK 5
Authors: Setiawan Ari Kurnia , Andry Johanes Fernandes
Published: November 2019

National Library of Indonesia (Perpusnas) is a public library located in Jakarta. In its operations Perpusnas already implemented Information Technology (IT) to support its activities, in IT implementation good IT Governance is needed to ensure that the IT is working consistently with business and produce the expected output. IT Governance is structure, process and mechanism that also includes objective making of the organization while considering the organization’s capability. With the good IT Governance Perpusnas can allocate its resource more efficiently and measure the running performance. This research will use COBIT 5 as the framework, the reason why COBIT 5 is chosen because COBIT 5 provides comprehensive framework that could help Perpusnas in achieving its IT Governance and IT management objectives. COBIT 5 enables IT to be organized and managed in the whole organization, it also could provide balance between the realization of benefits and risk optimization. Observation and interview is done in order of data collection in this research, the data then is analyzed and measured with the capability level in COBIT 5. Based on the analysis conducted the result obtained is. The average capability level of EDM01 is 1, on EDM02 is 3, on EDM03 is 2, on EDM04 is 3 and on EDM05 is 3. This research also provides recommendations that can be used as reference for Perpusnas to increase the performance of its IT Governance
The prevalence of various clinical forms of the disease and variants of CYP21A2 gene mutations in congenital adrenal cortical dysfunction in children and adolescents in the Republic of Tatarstan
Authors: Shaydullina M. R. , Sultanova A. S. , Khabibullina D. A. , Zamalova A. N.
Published: November 2019

Сongenital adrenal hyperplasia (CAH) – is one of the versions of inherited enzymopathy. If it was dedected too late, that can lead not only to some fatal consequences, but to patient’s death as well. Neonatal screening of CAH allows to detect the desease promtly and start an immediate therapy in order to prevent difficult complications of the desease and patient’s disablement.

Aim:Analisys of the frequency of CAH case rate within children in the Republic of Tatarstan (RT) after neonatal screening and also prevalence rate of different clinic forms of empairments and types of gene CYP21A2’s mutations.

Methods:Reports of the results of CAH screening by medicogenetic service in RT were analysed. Information about children born, detected cases of CAH was taken from statistic form № 12 “Information on the number of diseases, detected within patient residing in the service area of medical organization, Rosstat” during 2006–2018yrs. Materials for analysis of health clinic of children’s CAH were case histories of patient, observed in endocrinology department of GAUZ “Republican children clinic hospital” Ministry of Health of The Republic of Tatarstan (DRKB MZ RT). Molecular-genetic researches were conducted on the basis of Federal state budgetary institution “National medical center for endocrinology” of the Russian ministry of Health. (FGBU “NMIC of endocrinology) of The Russian ministry of Health) with the support of “Alfa Endo” program CAF charity foundation.

Results:During 2007–2017 yrs. according to the results of neonatal screening 32 children with CAH were detected. The case rate ranged from 1:5054 to 1:56 598 newborn. The maximum of the disease case in RT was detected in 2016 (11 children). With 24 children molecular-genetic analysis was conducted, as a result 24 gene CYP21A2’s mutations were detected in homo- and heterozygotic state. The most widely spread mutation turned to be 12spl, which was found in 45,8% of cases.

Conclusion:Conducted analysis confirms the necessity of the further study of the CAH case rate distinctions in different areas and cities of RT, and also upgrade of the organization and performance of the neonatal screening.
Congenital disorder of glycosilation PMM2-CDG
Authors: Kamalova A. A. , Shakirova A. R. , Shaydullina M. R. , Cheminava L. D. , Ganieva L. B. , Badretdinova A. N. , Saetov S. S.
Published: November 2019

Congenital glycosylation disorders represent a group of genetically determined diseases which violate the synthesis and addition of glycans to glycoproteins and glycolipids, and also the synthesis of glycosylphosphatidyl inositol. The most common defects are the defects of protein N-glycosylation. Jaken syndrome, a congenital disorder of PMM2-CDG glycosylation, is the most commonly diagnosed type (about 800 cases worldwide). However, there are only a few descriptions of clinical cases in the Russian literature. The article presents a clinical observation of a child with this type of congenital glycosylation disorder due to a defect in phosphomannomtase 2 (PMM2 gene). The diagnose was based on the combination of clinical, laboratory and instrumental data: a characteristic phenotype, hyperinsulinism, delayed physical and psychomotor development, neurological manifestations, coagulopathy, liver damage, exudative enteropathy, abnormal forms of transferrin, PMM2 gene mutations associated with Jaken’s syndrome. For the first time the authors described positive clinical and laboratory dynamics due to the inclusion of D-mannose to the therapy for this type of congenital glycosylation disorder.
Hearing function in twins from spontaneous and induced pregnancy
Authors: Rakhmanova I. V. , Sichinava L. G. , Lebedeva S. Yu.
Published: November 2019

In recent years, an increase in the frequency of multiple pregnancies has been observed worldwide, which is primarily associated with the widespread use of assisted reproductive technology for the treatment of infertility. Pregnancy resulting from in vitro fertilization is a high-risk group. In the world scientific literature there are practically no works on the study of auditory function in children from multiple pregnancy. As for the studies of the auditory function of children from multiple pregnancies, such works are practically absent in the literature. The article presents the results of an audiological examination of 204 children from twins, 94 of which were born as a result of using assisted reproductive technologies, and 110 from a spontaneous multiple pregnancy. According to an audiological survey using the method of otoacoustic emission at the frequency of product distortion in the expected period of labor, we have proven that the conception method (spontaneous or induced) does not affect the maturation of the auditory function in children from twins: registration of the distortion product otoacoustic emissions (DPOAE) test is 56,1 and 54,4% of cases, respectively. The auditory function of each child from one twin must be considered individually.
A modified damage index probability imaging algorithm based on delay-and-sum imaging for synthesizing time-reversed Lamb waves
Authors: Xia Qingwei , Liu Yanyan , Lu Yu , Cao Shuhao , Zhang Hanfei , Ma Shiwei
Published: November 2019

Imaging for damage in plate structure by Lamb waves is one of the most effective methods in the field of structural health monitoring. In order to improve the accuracy of damage localization, a novel method is proposed to modify damage exponent probability imaging algorithm based on delay-and-sum imaging by using time reversal Lamb waves. A new probability distribution function is introduced to improve the damage index probability method and is combined with delay-and-sum method for damage localization. Experimental results on aluminum plate show that the hybrid algorithm achieves better accuracy of damage location and imaging quality than the conventional delay-and-sum method.
Vibration analysis of reconditioned high-speed electric motors
Authors: Mikolajczak Pawel
Published: November 2019

This paper discusses the issue of assessing the condition of three-phase induction motors (which are used as power units for tools on manufacturing lines in the furniture industry) following major repairs. These high-speed motors differ from standard motors in higher frequency power input, more durable bearings and reinforced structure of the terminal part of the rotor shaft. The rotational speed of the rotor is 10,000-18,000 rpm. Such high values of rotational speed trigger a situation in which exceeding the allowable limit of residual unbalance for the rotor unit damages the motor. The damage might necessitate a comprehensive repair. Such cases are frequent. The conducted studies resulted in designing a vibration analysis for assessing the condition of reconditioned high-speed motors (a method for controlling the quality of repairs). Both high- and low-frequency analyses with a signal selection module and the basic general measurements were applied. The analysis provides the possibility of verifying the efficacy of reconditioning in relation to the mechanical validity of the repaired motors.
The model and simulation of low impact development of the sponge airport, China
Authors: Peng Jing , Ouyang Jiayi , Yu Lei , Wu Xinchen
Published: November 2019

Recently urban waterlogging problems have become more and more serious, and the construction of an airport runway makes the impervious area of the airport high, which leads to the deterioration of the water environment and frequent waterlogging disasters. It is of great significance to design and construct the sponge airport with low impact development (LID) facilities. In this paper, we take catchment N1 of Beijing Daxing International Airport as a case study. The LID facilities are designed and the runoff process of a heavy rainfall in catchment N1 is simulated before and after the implementation of LID facilities. The results show that the total amount of surface runoff, the number of overflow junctions and full-flow conduits of the rainwater drainage system in catchment N1 of Beijing Daxing International Airport are significantly reduced after the implementation of the LID facilities. Therefore, the application of LID facilities has greatly improved the ability of the airport to remove rainwater and effectively alleviated the risk of waterlogging in the airport flight area. This study provides theoretical support for airport designers and managers to solve flood control and rainwater drainage problems and has vital practical significance.
Identification of Indium Tin Oxide Nanoparticle-Binding Peptides via Phage Display and Biopanning Under Various Buffer Conditions
Authors: Nakazawa Hikaru , Umetsu Mitsuo , Hirose Tatsuya , Hattori Takamitsu , Kumagai Izumi
Published: November 2019

Background:

By recent advances in phage-display approaches, many oligopeptides
exhibiting binding affinities for metal oxides have been identified. Indium tin oxide is one of the
most widely used conductive oxides, because it has a large band gap of 3.7–4.0 eV. In recent years,
there have been reports about several ITO-based biosensors. Development of an ITO binding
interface for the clustering of sensor proteins without complex bioconjugates is required.

Objective:

In this article, we aimed to identify peptides that bind to indium tin oxide nanoparticles
via different binding mechanisms.

Methods:

Indium tin oxide nanoparticles binding peptide ware selected using phage display and
biopanning against indium tin oxide, under five different buffer conditions and these peptides
characterized about binding affinity and specificity.

Results:

Three types of indium tin oxide nanoparticles-binding peptides were selected from 10
types of peptide candidates identified in phage display and biopanning. These included ITOBP8,
which had an acidic isoelectric point, and was identified when a buffer containing guanidine was
used, and ITOBP6 and ITOBP7, which contained a His-His-Lys sequence at their N-termini, and
were identified when a highly concentrated phosphate elution buffer with a low ionic strength was
used. Among these peptides, ITOBP6 exhibited the strongest indium tin oxide nanoparticlesbinding
affinity (dissociation constant, 585 nmol/L; amount of protein bound at saturation, 17.5
nmol/m 2 - particles).

Conclusion:

These results indicate that peptides with specific binding properties can be obtained
through careful selection of the buffer conditions in which the biopanning procedure is performed.
Production and Preliminary In Vivo Evaluations of a Novel in silico-designed L2-based Potential HPV Vaccine
Authors: Negahdaripour Manica , Nezafat Navid , Heidari Reza , Erfani Nasrollah , Hajighahramani Nasim , Ghoshoon Mohammad B. , Shoolian Eskandar , Rahbar Mohammad R. , Najafipour Sohrab , Dehshahri Ali , Morowvat Mohammad H. , Ghasemi Younes
Published: November 2019

Background:

L2-based Human Papillomavirus (HPV) prophylactic vaccines, containing
epitopes from HPV minor capsid proteins, are under investigation as second-generation HPV vaccines.
No such vaccine has passed clinical trials yet, mainly due to the low immunogenicity of peptide vaccines;
so efforts are being continued. A candidate vaccine composed of two HPV16 L2 epitopes, flagellin
and a Toll-Like Receptor (TLR) 4 agonist (RS09) as adjuvants, and two universal T-helper
epitopes was designed in silico in our previous researches.

Methods:

The designed vaccine construct was expressed in E. coli BL21 (DE3) and purified through
metal affinity chromatography. Following mice vaccination, blood samples underwent ELISA and
flow cytometry analyses for the detection of IgG and seven Th1 and Th2 cytokines.

Results:

Following immunization, Th1 (IFN-γ, IL-2) and Th2 (IL-4, IL-5, IL-10) type cytokines, as
well as IgG, were induced significantly compared with the PBS group. Significant increases in IFN-γ,
IL-2, and IL-5 levels were observed in the vaccinated group versus Freund’s adjuvant group.

Conclusion:

The obtained cytokine induction profile implied both cellular and humoral responses,
with a more Th-1 favored trend. However, an analysis of specific antibodies against L2 is required to
confirm humoral responses. No significant elevation in inflammatory cytokines, (IL-6 and TNF-α),
suggested a lack of unwanted inflammatory side effects despite using a combination of two TLR agonists.
The designed construct might be capable of inducing adaptive and innate immunity; nevertheless,
comprehensive immune tests were not conducted at this stage and will be a matter of future work.
Allergen-specific Immunotherapy for Inhalant Allergens in Children
Authors: Caffarelli Carlo , Cangemi Jessica , Mastrorilli Carla , Giannetti Arianna , Ricci Giampaolo
Published: November 2019

:

Allergen-specific immunotherapy (AIT) for aeroallergens consists of the administration
of standardized allergen extracts to patients with respiratory IgE-mediated diseases to the same allergen
in order to achieve immune tolerance to the allergen and prevent the onset of symptoms.
AIT is usually delivered by sublingual (SLIT), subcutaneous (SCIT) route. AIT with one or multiple
allergens currently represents the only causal treatment able to change the natural history of allergic
airway diseases. Significant progresses have been made in terms of AIT efficacy and safety.

:

In this paper, mechanisms of action, indication and side effects of allergen immunotherapy are reviewed.

:

SLIT and SCIT have been found to be effective in the treatment of asthma and rhinoconjunctivitis
due to inhalant allergens. The route of AIT administration should be selected on availability, cost
(dependent from the local health system), tolerability (better for SLIT), patient’s preference (injections
are less accepted in young children), and adherence (higher for SCIT beyond pediatric age).
However, it should be taken into account that metanalyses on AIT do not consider that effectiveness
and safety depend upon the product chosen for treatment. Each product should be separately
assessed to avoid generalization on administration routes or age group that may affect the decision.
Headliner in Physiology and Management of Childhood Asthma: Hypothalamic-Pituitary-Adrenal Axis
Authors: Akcan Nese , Bahceciler Nerin N.
Published: November 2019

Asthma is the most common chronic inflammatory disease of children. Inhaled corticosteroids
(ICS) are the cornerstone of asthma therapy which are the most effective, commonly used
treatment of persistent asthma. Mostly, studies on the relationship between asthma and cortisol
have focused on side effects of treatment. Recently, asthmatic patients not treated with ICS have
been reported to have an attenuated activity and/or responsiveness of their Hypothalamic-Pituitary-
Adrenal (HPA) axis. Moreover, it has been proposed that asthma worsening with stress may be due
to a dysfunctional HPA axis, or cortisol insensitivity due to chronic psychological stress through
impaired glucocorticoid receptor expression or function. Although long-term ICS treatment might
produce adrenal suppression or iatrogenic Cushing syndrome, improvement of adrenal function has
also been detected in some of asthmatic cases. Thus, the response scheme of HPA axis still contains
undiscovered features in asthma. The management of asthma can be improved by increasing
knowledge on the role of HPA axis in asthma pathophysiology. The risk for side effects of ICS can
be minimized through increased awareness, early recognition of at-risk patients and regular patient
follow-up. This review was written to draw attention to the role of HPA axis in both asthma and its
treatment and to illustrate a follow up algorithm of HPA axis in the management of asthma.
Benefits of Pulmonary Rehabilitation in Patients with COPD with Use and without the Use of Supplemental Oxygen During Exercise
Authors: Peña Jhonatan Betancourt , Ávila Valencia Juan Carlos , Assis Jorge Karim , Gutiérrez Hugo Hurtado , Córdoba Vicente Benavides
Published: November 2019

Objective:

To determine the effects of a pulmonary rehabilitation program in patients with COPD who use and do not use supplemental oxygen during exercise.

Materials and Methods:

Prospective longitudinal descriptive study on 59 patients with COPD who were part of a pulmonary rehabilitation program and who were classified into two groups: a group that required supplemental oxygen during rehabilitation and another that did not.

Results:

31 patients were linked to the group that used oxygen during rehabilitation and 28 patients who did not use it. The average age was 69.1 ± 10.6 years old. The mMRC dyspnea decreased 0.7 ± 0.2 (p = 0.000) in the group that used oxygen and 0.8 ± 0.1 (p = 0.000) in the group that did not use it. The distance increased 45.9 meters ± 7.2 (p = 0.000) in the group that used oxygen and 65.2 meters ± 16.3 (p = 0.001) in the group that did not use it.

Conclusion:

Both groups showed significant improvements in dyspnea and aerobic capacity, however, there was a greater increase in the group that did not use oxygen.
Meta-analysis and Approach of the Real Impact of Anorexigenic Drugs in the Obesity in Humans: The Last Five Years of the Randomized Studies
Authors: Garcia Ramirez Ana Valéria , Filho Durval Ribas , Zotarelli Filho Idiberto José
Published: November 2019

Introduction:

Obesity shows a multifactorial disease and presents a serious public health
problem, with an alarming epidemic character. According to NHANES (National Health and Nutrition
Examination Survey) from 2015 to 2016, 39.6% of American adults and 18.5% of young people were
obese and 7.7% of adults and 5.6% of young people had severe obesity. Brazil ranks fifth in the world
ranking, with about 18 million people reaching up to 70 million overweight individuals. Despite shortterm
weight loss with diet and exercise, weight regain continues to be a concern. Anti-obesity drugs,
such as Sibutramine (SIB), Phentermine (PHEN), Fenproporex (FEN), Mazindol (MAZ), Amfepramone
(AMFE) and Orlistat (ORL) may play a role in weight reduction in patients whose condition
is refractory to non- and maintenance of weight loss.

Objective:

A systematic review followed by meta-analysis of randomized clinical trials over the past
five years to explore the efficacy and safety of anorexigenic drugs for weight reduction and consequent
treatment of obesity.

Methods:

The search strategy in MEDLINE / Pubmed, Web of Science, ScienceDirect Journals (Elsevier),
Scopus (Elsevier), OneFile (Gale) is as follows : - search for mesh terms (Sibutramine, Phentermine,
Fenproporex, Mazindol, Amfepramone , Orlistat, Weight loss, Safety), and the use of booleans
"and" between mesh terms and "or" among historical findings.

Results:

It was observed that in the last five years of randomized studies no significant general complications
were found, with only 5.7%. The mean overall weight loss was 6.18 (± 2.8) kg in the mean time
of 12 months. The overall success rate among these drugs was 80.18%. The p-value values did not present
a significant statistical difference, being p <0.05 within each drug group analyzed, for both weight
and success rates.

Conclusion:

The scientific findings of randomized studies on the use of anorexigenic drugs to treat
obesity have shown safety and efficiency in the last five years, with a reasonable weight loss and no
significant complications.
A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds
Authors: Kładna Aleksandra , Berczyński Paweł , Dündar Oya B. , Kruk Irena , Torun Beyza , Aboul-Enein Hassan Y.
Published: November 2019

Background:

Stilbene phytalexis (1,2-diphenyloethylen) and benzamide are beneficial
for human health. To increase the stilbene ring activity, a new series of its derivatives containing
benzamide structure was synthesized and evaluated for their in vitro antioxidant power.
Methods:

Methods:

1H nuclear magnetic resonance, mass spectroscopy, and chromatographic analyses were
used to confirm the successful synthesis. The antioxidant properties were determined by the elimination
of O2˙-, HO˙ , DPPH˙ , ABTS+˙ radicals, total antioxidant status (TAS) and the ferric
reducing antioxidant activities (TAC) measurements.

Results:

Stilbenebenzamide compounds showed a wide spectrum of antioxidant ability; however,
their total antioxidant power was weaker than those of butylated hydroxytoluene (BHT), ascorbic
acid, and resveratrol. The highest antiradical activity towards O2˙ and HO˙ was shown by the
compounds with structures containing amine group (SBEBA, SBA) (O2˙: 37.7 – 38.0% and 40.8
– 43.5%, HO˙ : 29.8%, 28.7% inhibition, respectively) at1.25 mM concentration. The antiradical
power of SBEBA (0.29) in DPPH˙ assay was lower than those of resveratrol (1.83), ascorbic acid
(3.63) and BHT (4.09). The TAS values of the synthesized compounds ranged from 152.9±5.3 to
240.2±6.7μM trolox equivalent/gram (TE/g) and were much lower than those of BHT
(1304±43.0), reservatrol (1360±29.0) and ascorbic acid (2782±39.7) μM TE/g. Similarly, the TAC
values ranging from 29.7±0.9 to 41.5±1.6 μM TE were weaker than that of resveratrol (239.2 ±6.7
μM TE/g).

Conclusion:

The results suggest that the presence of the hydroxyl group in the stilbene ring should
be considered in the further design of stilbenebenzamide compounds to enhance their antioxidant
activity.
In Vitro Anticancer Activity of Virgin Coconut Oil and its Fractions in Liver and Oral Cancer Cells
Authors: Verma Poonam , Naik Sanjukta , Nanda Pranati , Banerjee Silvi , Naik Satyanarayan , Ghosh Amit
Published: November 2019

Background:

Coconut oil is an edible oil obtained from fresh, mature coconut kernels. Few studies
have reported the anticancer role of coconut oil. The fatty acid component of coconut oil directly targets the
liver by portal circulation and as chylomicron via lymph. However, the anti-cancer activity of coconut oil
against liver cancer cells and oral cancer cells is yet to be tested. The active component of coconut oil, that is
responsible for the anticancer activity is not well understood. In this study, three different coconut oils, Virgin
Coconut Oil (VCO), Processed Coconut Oil (PCO) and Fractionated Coconut Oil (FCO), were used.

Objective:

Based on previous studies, it can be hypothesized that fatty acids in coconut oil may have anticancer
potential and may trigger cell death in cancer cell lines.

Methods:

Each cell line was treated with different concentrations of Virgin Coconut Oil (VCO), Processed
Coconut Oil (PCO) and Fractionated Coconut Oil (FCO). The treated cells were assayed by MTT after 72 hr of
incubation. The fatty acid composition of different coconut oils was analyzed by gas chromatography.

Result:

Different concentrations of coconut oils were used to treat the cells. Interestingly, the anticancer efficacy
of VCO, PCO and FCO was not uniform, rather the efficacy varied from cell line to cell line. Only 20% VCO
showed significant anticancer activity in HepG2 cells in comparison to 80% PCO against the KB cell line. Remarkably,
20% of PCO and 5% of FCO showed potential growth inhibition in the KB cell line as compared to
80% PCO in HepG2 cells. Moreover, there was a difference in the efficacy of VCO, PCO and FCO, which
might be due to their fatty acid composition. Comparing the anticancer efficacy of VCO, PCO and FCO in this
study helped to predict which class of fatty acids and which fatty acid might be associated with the anticancer
activity of VCO.

Conclusion:

This study shows that VCO, PCO and FCO have anticancer efficacy and may be used for the
treatment of cancer, especially liver and oral cancer.
p-Cymene Modulate Oxidative Stress and Inflammation in Murine Macrophages: Potential Implication in Atherosclerosis
Authors: Wu Tong , Mazhar Zahra , Alsayrafi Dhuha , Garelnabi Mahdi
Published: November 2019

Introduction:

p-Cymene (p-CYM) is a common chemical used in air fresheners.

Objective:

The study was designed to investigate the molecular effect of p-CYM on macrophages.

Materials and Methods:

Macrophages (RAW 264.7) were treated with p-CYM (50 uM/L, 150 uM/L
and 250 uM/L) for 6 hours, and 24 hours). Gene involved in inflammation, such as the Tumor Necrosis
Factor-alpha (TNF-α), and the Monocyte Chemoattractant Protein-1 (MCP-1) and other genes
known for their antioxidant activity such as the Paraoxonase 1 (PON-1) were analyzed.

Results:

Cells treated with p-CYM have shown 30% up-regulation of MCP-1 after 24 hour of exposure;
and also a differential up-regulation of TNF-α. However, treatment with p-CYM has resulted in
a considerable (37%) dose-dependent downregulation of PON-1 after 24 hours of exposure. PON-1
is known for its antioxidant properties protecting High-Density Lipoproteins (HDL) from oxidation.

Conclusion::

Our findings demonstrate that exposure to p-CYM over time promotes oxidative stress
by downregulating antioxidants genes as shown in PON-1 and also stimulates inflammation, a key
process during the initiation and progression of atherosclerosis.
Cannabidiol Partially Blocks the Excessive Sleepiness in Hypocretindeficient Rats: Preliminary Data
Authors: Murillo-Rodríguez Eric , Millán-Aldaco Diana , Palomero-Rivero Marcela , Morales-Lara Daniela , Mechoulam Raphael , Drucker-Colín René
Published: November 2019

Background:

Excessive daytime sleepiness and cataplexy are among the symptoms of narcolepsy,
a sleep disorder caused by the loss of hypocretin/orexin (HCRT/OX) neurons placed into the
Hypothalamus (LH). Several treatments for managing narcolepsy include diverse drugs to induce
alertness, such as antidepressants, amphetamine, or modafinil, etc. Recent evidence has shown that
cannabidiol (CBD), a non-psychotropic derived from Cannabis sativa, shows positive therapeutic effects
in neurodegenerative disorders, including Parkinson´s disease. Furthermore, CBD provokes
alertness and enhances wake-related neurochemicals in laboratory animals. Thus, it is plausible to hypothesize
that excessive somnolence observed in narcolepsy might be blocked by CBD.

Objective:

Here, we determined whether the systemic injection of CBD (5mg/kg, i.p.) would block the
excessive sleepiness in a narcoleptic model.

Methods:

To test this idea, the neurotoxin hypocretin-2-saporin (HCRT2/SAP) was bilaterally injected
into the LH of rats to eliminate HCRT leading to the establishment of narcoleptic-like behavior. Since
excessive somnolence in HCRT2/SAP lesioned rats has been observed during the lights-off period,
CBD was administered at the beginning of the dark phase.

Results:

Hourly analysis of sleep data showed that CBD blocked the sleepiness during the lights-off
period across 7h post-injection in lesioned rats.

Conclusion:

Taking together, these preliminary findings suggest that CBD might prevent sleepiness in
narcolepsy.
Cytotoxic Constituents from the Bark of Erythrina poeppigiana Against the MCF-7 Breast Cancer Cell Lines
Authors: Herlina Tati , Merlin  , Azlan Mohd. , Supratman Unang
Published: November 2019

Background:

Erythrina poeppigiana (Leguminosae) is a high-growing plant with an orange
flower that is widely distributed in tropical and subtropical countries. This particular plant is
widely used in traditional medicine for gynecological complications and the treatment of various
diseases. There exists no previous information regarding cytotoxic compounds from this plant.

Objective:

This research is to isolate cytotoxic compounds from E. poeppigiana.

Methods:

The isolation step was carried out using a combination of chromatographic techniques to
obtain isolated three compounds (1, 2, and 3).

Results:

The chemical structure of isolated compounds was elucidated by spectroscopic methods and
identified as β-erythroidine (1), 8-oxo-β-erythroidine (2), and 8-oxo-α-erythroidine (3). Compounds
(1-3) showed cytotoxic activity against MCF-7 breast cancer line with IC50 values of 36.8, 60.8 and
875.4 μM, respectively.

Conclusion:

Three compounds have been successfully isolated from Erythrina poeppigiana (Leguminosae),
showing cytotoxic properties against MCF-7 breast cancer line. Structure-activity relationship
studies showed that the presence of enone moiety on compound 1 can reduce its cytotoxic activity
towards MCF-7 breast cancer line.
Substrate Integrated Waveguide Based Bandpass Filter with Defected Ground Structure for FMCW Radar Application
Authors: Mahant Keyur , Mewada Hiren
Published: November 2019

Aims :

Substrate Integrated Waveguide (SIW) based bandpass filter is presented in this
paper.

Objectives:

In the proposed design, bandpass response is achieved by combining SIW structure
with elliptic shaped Defected Ground Structure (DGS) cells.

Methods :

Simulation of the proposed structure is carried out using commercial software Ansoft
High Frequency Structure Simulator (HFSS), which is a three-dimensional frequency domain
electromagnetic solver based on the Finite Element Method (FEM). Analysis of three different
types of DGS cells including rectangular, circular and elliptical has been carried out. Moreover,
Frequency tuning is also carried out by changing the dimension of DGS.

Result :

Proposed filter is fabricated on the dielectric material RT duroid 5880 with the dielectric
constant ɛεr=2.2, dissipation factor tanδ=4 x 10-4 and height h= 0.508 mm. The measured return
loss of 25.71 dB and insertion loss of 1.24 dB with 3 dB Fractional Bandwidth (FBW) of 4.8% at
the center frequency of 7 GHz.

Conclusion :

Good agreements are observed between the experimental results and the simulations.
The Potential Role of Claudins in Regulation of Metastasis and Development of Drug Resistance in Breast Cancer
Authors: Patadia Hemantkumar , Priyadarshini Ankita , Ranade Jay , Gangawane Ajit
Published: November 2019

Background:

Breast Cancer is a recurrent problem across the world. According to a report, breast cancer has the second highest mortality rate in women globally. Despite having an advanced degree of chemotherapy, resistance is developed against the therapies. Studies showed that anthracyclins like doxorubicin used in the treatment of breast cancer are found to develop resistance, which is not easy to identify. Mutations in the tumor suppressor gene P53 are associated with the primary resistance to doxorubicin and thus inducing an early relapse of breast tumors. Resistance against Doxorubicin is not identifiable easily. Development of resistance and metastasis of tumors are the two processes that cannot be separated from each other. It is widely known that endothelium has a major role in controlling metastasis and tumor cell invasion. Endothelial cells express different adhesion molecules during recruitment of leukocytes in localized area, which is called leukocyte extravasation or diapedesis, or leukocyte trans endothelial migration (LEM). LEM (leukocyte trans endothelial migration) plays crucial role in the inflammation of breast cancer tissues.

Objective:

Predicting the role of deregulation of claudins in leukocyte trans endothelial migration in breast cancer metastasis and resistance.

Method:

The breast cancer proteomic metadata was collected and compared among the common candidates. The enrichment analysis of those common candidates was performed using a network analyst.

Result:

The analysis of breast cancer genes obtained from dbDEPC showed probable involvement of 4 candidate genes belonging to the claudin family. Claudins are responsible for the migration of an increased amount of leukocytes in the breast tumor region, which increases the inflammation and may contribute to worsening the disease progression.

Conclusion:

We believe these candidates also contribute in the development of resistance to chemotherapy.
Lung Cancer Prediction Using Random Forest
Authors: Rajini A. , Jabbar M.A.
Published: November 2019

Background:

In recent years, lung cancer is a common cancer across the globe. For the
early prediction of lung cancer, medical practitioners and researchers require an efficient predictive
model, which will reduce the number of deaths. This paper proposes a lung cancer prediction model
by using the Random Forest Classifier, which aims at analyzing symptoms (gender, age, air pollution,
weight loss, etc.).

Objective:

This work addresses the problem of classification of lung cancer data using the Random
Forest Algorithm. Random Forest is the most accurate learning algorithm and many researchers in
the healthcare domain use it.

Method:

This paper deals with the prediction of lung cancer by using Random Forest Classifier.

Results:

Proposed method (Random Forest Classifier) applied on two lung cancer datasets, achieved an accuracy of 100% for the lung cancer dataset-1 and 96.31 on dataset-2. In the prediction of lung cancer, the random forest has shown improved accuracy compared with other methods.

Conclusion:

This predictive model will help health professionals in predicting lung cancer at an early stage.
A Concise Account on Eco-friendly Synthetic Strategies for Pyrazole Heterocycles
Authors: Singh Pargat , Nath Mahendra
Published: November 2019

Five membered nitrogen heterocycles are historically known to exhibit diverse therapeutic
properties. In particular, the pyrazole analogues have shown a wide range of pharmacological profiles
and a number of drugs containing this scaffold approved for the treatment of various ailments and
disorders. Hence, a lot of efforts have been made to develop efficient synthetic strategies for the
preparation of a variety of pyrazoles in the past several decades. However, this review describes the
environmentally benign protocols for the synthesis of substituted and fused pyrazole molecules.
Topology optimization and rim design
Authors: Rashwan Alkentar
Published: November 2019

A goal of this article is to show the development of the car wheel rims along with the progress of the manufacturing technologies over the past few years. To achieve this goal, topology optimization and generative design usage have been reviewed in this work. The research has focused on the main factors, which affect the life of car wheel rim, and it has shed the light on the effect of the topology optimization and the generative design on the manufacturing of the car wheel rims. Since the main factors above-mentioned are the: forces, material preferences and topology optimization, the study has covered the results of the studies made on each part along with the technology progress. Moreover, the article has explained the methodology main steps of the topology optimization and the generative design and their principles.
A homlokmarási technológia hőkamerás elemzése a fordulatszám változtatása mellett
Authors: Prezenszki Dorottya , Wesser Csaba , Bodzás Sándor
Published: November 2019

A publikáció célkitűzése homlokmarási technológia során a forgácsleválasztáskor képződő hőmérsékleti zóna vizsgálata hőkamerával. A vizsgálatot diszkrét fordulatszám értékek változtatásával a többi technológiai paraméter állandóssága mellett végezzük el. Megtervezzük a mérési koncepciót. A kísérletek elvégezte után elemezzük a kapott hőképeket.
Simulation of production processes with Plant Simulation
Authors: Miltényi Máté , Czégé Levente
Published: November 2019

This article presents the modelling of interconnected companies’ logistic processes with Tecnomatix Plant Simulation by Siemens. It has two main parts. The first contains the details of recognition including simulation. The second part presents the modelling with Tecnomatix Plant Simulation. My publication is supported by the EFOP3.6.1-16-2016-00022 project. The project is co-financed by the European Union and the European Social Fund.
Floodresc - árvízi katasztrófahelyzetek kezelése a Hernád vízgyűjtőben
Authors: Dobos Endre , Vágó János , Pecsmány Péter , Blistan Peter , Zelenáková Martina , Ladányi Richárd , Kiss Levente
Published: November 2019

A Floodresc projekt célja egy olyan térinformatikai döntéstámogató rendszer kifejlesztése, amely a Hernád folyó esetleges árvizei során segítheti a megyei katasztrófavédelmi igazgatóság védekezési, mentési feladatait. A döntéstámogató rendszer főbb elemei a teljes vízgyűjtőt lefedő térinformatikai adatbázis, az elöntött területek kiterjedését időben előre jelző, modellező alkalmazás, amelyekre a védekezéshez kapcsolódó szállítási feladatokat támogató logisztikai tervező eszköz épül.
Precíziós öntözéstechnológia alkalmazásának és kialakításának vizsgálata
Authors: Szabó Andrea , Tömöri F , Vad Attila Miklós , Tamás János , Nagy Attila
Published: November 2019

A szélsőséges időjárási viszonyok miatt napjainkban az öntözést egyre szükségesebb tényezőnek tartják. A növény vízigényeinek és a rendelkezésre álló vízkészletek felmérése után dönteni kell, milyen öntözési módszert alkalmazunk. Szántóföldi körülmények között az egyik leggyakrabban használt módszer az esőszerű öntözés, melynek több típusát ismerjük (pl. lineár, csévélődobos öntözőberendezés). A szántóföldön alkalmazott szórófejek egyenletességét a Christiansen-féle egyenletességi tényező (CU%) és az eloszlási egyenletességi tényező (distributon uniformity) (DU%) megadásával jellemezhetjük. Az együtthatókat csapadékmérők által felfogott vízmennyiség adataiból lehet megállapítani. A vizsgálatainkat 2019. júliusában és augusztusában 3 időpontban végeztük el a Debreceni Egyetem Látóképi Növénytermesztési Kísérleti Telepén és egy nyírbátori cég lineár öntözőberendezésein. Célul tűztük ki a hagyományos lineár technológia és a precíziós lineár öntözési technológia által kijuttatott víz mennyiség szórás egyenletességének összehasonlító értékelését. Emellett a kukorica intercepciós értékeknek a vizsgálatát is elvégeztük.