bluuebunny/crossref_metadata_2025 huggingface dataset:
A framework for estuarine future sea-level scenarios: Response of the industrialised Elbe estuary to projected mean sea level rise and internal variability
Authors: Pein Johannes , Staneva Joanna , Mayer Bernhard , Palmer Matthew D. , Schrum Corinna
Published: March 2023

In this study, we apply probabilistic estimates of mean sea level (MSL) rise and a sub-set of regional climate model ensemble simulations to force a numerical model of the southern North Sea, downscaling projected sea level variability to the Elbe estuary that serves as a prototype for an industrialised meso-tidal estuary. The specific forcing combination enables a localised projection of future estuarine hydrodynamics accounting for the spread of projected global sea level rise and the spread of the regional climate projection due to internal variability. Under the applied high-emission scenario, the Elbe estuary shows high decadal rates of mean water level (MWL) rise beyond 19 mm y-1, increase in the tidal range of up to 14 mm y-1 and increase in extreme water levels of up to 18 mm y-1. The bandwidth of the estuarine response is also high. For example, the range of average monthly extreme water levels is up to 0.57 m due to the spread of projected global sea level rise, up to 0.58 m due to internal variability whereas seasonal range attains 1.99 m locally. In the lower estuary, the spread of projected global sea level rise dominates over internal variability. Internal variability, represented by ensemble spread, notably impacts the range of estuarine water levels and tidal current asymmetry in the shallow upper estuary. This area demonstrates large seasonal fluctuations of MWLs, the M2 tidal amplitude and monthly extreme water levels. On the monthly and inter-annual time scales, the MWL and M2 amplitude reveal opposite trends, indicative of a locally non-linear response to the decadal MSL rise enforced at the open boundary. Overall, imposed by the climate projections decadal change and MSL rise enhance the horizontal currents and turbulent diffusivities whereas internal variability locally mitigates sea level rise–driven changes in the water column. This work establishes a framework for providing consistent regionalised scenario-based climate change projections for the estuarine environment to support sustainable adaptation development.
Estimation of the Manning’s n coefficient in multi-constituent tidal models by assimilating satellite observations with the adjoint data assimilation
Authors: Wang Daosheng , Jiang Jinglu , Wei Zilu , Cheng Jun , Zhang Jicai
Published: March 2023

The bottom friction is critical for the dissipation of the global tidal energy. The bottom friction coefficient is traditionally determined using the Manning’s n formulation in tidal models. The Manning’s n coefficient in the Manning’s n formulation is vital for the accurate simulation and prediction of the tide in coastal shallow waters, but it cannot be directly measured and contains large amounts of uncertainties. Based on a two-dimensional multi-constituent tidal model with the adjoint data assimilation, the estimation of the Manning’s n coefficient is investigated by assimilating satellite observations in the Bohai, Yellow and East China Seas with the simulation of four principal tidal constituents M2, S2, K1 and O1. In the twin experiments, the Manning’s n coefficient is assumed to be constant, and it is estimated by assimilating the synthetic observations at the spatial locations of the satellite tracks. Regardless the inclusion of artificial random observational errors associated with synthetic observations, the model performance is improved as evaluated by the independent synthetic observations. The prescribed ‘real’ Manning’s n coefficient is reasonably estimated, indicating that the adjoint data assimilation is an effective method to estimate the Manning’s n coefficient in multi-constituent tidal models. In the practical experiments, the errors between the independent observations at the tidal gauge stations and the corresponding simulated results of the four principal tidal constituents are substantially decreased under both scenarios of the constant and spatially-temporally varying Manning’s n coefficient estimated by assimilating the satellite observations with the adjoint data assimilation. In addition, the estimated spatial and temporal variation trend is robust and not affected by the model settings. The spatially-temporally varying Manning’s n coefficient is negatively correlated with the current speed and shows significant spatial variation in the shallow water areas. This study demonstrates that the Manning’s n coefficient can be reasonably estimated by the adjoint data assimilation, which allows significant improvement in accurate simulation of the ocean tide.
Genetic engineering strategies to enhance antitumor reactivity and reduce alloreactivity for allogeneic cell-based cancer therapy
Authors: Chen Yuning , Zhu Yichen , Kramer Adam , Fang Ying , Wilson Matthew , Li Yan-Ruide , Yang Lili
Published: March 2023

The realm of cell-based immunotherapy holds untapped potential for the development of next-generation cancer treatment through genetic engineering of chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapies for targeted eradication of cancerous malignancies. Such allogeneic “off-the-shelf” cell products can be advantageously manufactured in large quantities, stored for extended periods, and easily distributed to treat an exponential number of cancer patients. At current, patient risk of graft-versus-host disease (GvHD) and host-versus-graft (HvG) allorejection severely restrict the development of allogeneic CAR-T cell products. To address these limitations, a variety of genetic engineering strategies have been implemented to enhance antitumor efficacy, reduce GvHD and HvG onset, and improve the overall safety profile of T-cell based immunotherapies. In this review, we summarize these genetic engineering strategies and discuss the challenges and prospects these approaches provide to expedite progression of translational and clinical studies for adoption of a universal cell-based cancer immunotherapy.
Long-term warming modulates diversity, vertical structuring of microbial communities, and sulfate reduction in coastal Baltic Sea sediments
Authors: Seidel Laura , Sachpazidou Varvara , Ketzer Marcelo , Hylander Samuel , Forsman Anders , Dopson Mark
Published: March 2023

Coastal waters such as those found in the Baltic Sea already suffer from anthropogenic related problems including increased algal blooming and hypoxia while ongoing and future climate change will likely worsen these effects. Microbial communities in sediments play a crucial role in the marine energy- and nutrient cycling, and how they are affected by climate change and shape the environment in the future is of great interest. The aims of this study were to investigate potential effects of prolonged warming on microbial community composition and nutrient cycling including sulfate reduction in surface (∼0.5 cm) to deeper sediments (∼ 24 cm). To investigate this, 16S rRNA gene amplicon sequencing was performed, and sulfate concentrations were measured and compared between sediments in a heated bay (which has been used as a cooling water outlet from a nearby nuclear power plant for approximately 50 years) and a nearby but unaffected control bay. The results showed variation in overall microbial diversity according to sediment depth and higher sulfate flux in the heated bay compared to the control bay. A difference in vertical community structure reflected increased relative abundances of sulfur oxidizing- and sulfate reducing bacteria along with a higher proportion of archaea, such as Bathyarchaeota, in the heated compared to the control bay. This was particularly evident closer to the sediment surface, indicating a compression of geochemical zones in the heated bay. These results corroborate findings in previous studies and additionally point to an amplified effect of prolonged warming deeper in the sediment, which could result in elevated concentrations of toxic compounds and greenhouse gases closer to the sediment surface.
Protection from successive Omicron variants with SARS-CoV-2 vaccine and monoclonal antibodies in kidney transplant recipients
Authors: Moal Valérie , Valade Margaux , Boschi Céline , Robert Thomas , Orain Nicolas , Bancod Audrey , Edouard Sophie , Colson Philippe , La Scola Bernard
Published: March 2023

Introduction

Kidney transplant recipients (KTRs) are at high risk of severe COVID-19, even when they are fully vaccinated. Additional booster vaccinations or passive immunization with prophylactic monoclonal antibodies are recommended to increase their protection against severe COVID-19.

Methods

Here, we describe the neutralization of SARS-CoV-2 Delta, Omicron BA.1, BA.2, BA.4, and BA.5 variants, firstly by 39 serum samples from vaccinated KTRs exhibiting anti-spike antibody concentrations ≥264 binding antibody units (BAU)/mL and, secondly, by tixagevimab/cilgavimab.

Results

No neutralization was observed for 18% of the KTRs, while serum from only 46% of patients could neutralize the five variants. Cross-neutralization of the Delta and Omicron variants occurred for 65–87% of sera samples. The anti-spike antibody concentration correlated with neutralization activity for all the variants. The neutralization titers against the Delta variant were higher in vaccinated KTRs who had previously presented with COVID-19, compared to those KTRs who had only been vaccinated. Breakthrough infections occurred in 39% of the KTRs after the study. Tixagevimab/cilgavimab poorly neutralizes Omicron variants, particularly BA.5, and does not neutralize BQ.1, which is currently the most prevalent strain.

Discussion

As a result, sera from seropositive vaccinated KTRs had poor neutralization of the successive Omicron variants. Several Omicron variants are able to escape tixagevimab/cilgavimab.
3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma
Authors: Zhuo Wenkun , Lian Zheng , Bai Wenzhe , Chen Yanrong , Xia Huanling
Published: March 2023

Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug.

Objective: 2D- and 3D-QSAR (structure–activity relationship quantification) models were established to predict the anti-tumor activity of dipeptide-alkylated nitrogen-mustard compounds.

Method: In this study, a linear model was established using a heuristic method (HM) and a non-linear model was established using the gene expression programming (GEP) algorithm, but there were more limitations in the 2D model, so a 3D-QSAR model was introduced and established through the CoMSIA method. Finally, a series of new dipeptide-alkylated nitrogen-mustard compounds were redesigned using the 3D-QSAR model; docking experiments were carried out on several compounds with the highest activity against tumors.

Result: The 2D- and 3D-QSAR models obtained in this experiment were satisfactory. A linear model with six descriptors was obtained in this experiment using the HM through CODESSA software, where the descriptor “Min electroph react index for a C atom” has the greatest effect on the compound activity; a reliable non-linear model was obtained using the GEP algorithm model (the best model was generated in the 89th generation cycle, with a correlation coefficient of 0.95 and 0.87 for the training and test set, respectively, and a mean error of 0.02 and 0.06, respectively). Finally, 200 new compounds were designed by combining the contour plots of the CoMSIA model with each other, together with the descriptors in the 2D-QSAR, among which compound I1.10 had a high anti-tumor and docking ability.

Conclusion: Through the model established in this study, the factors influencing the anti-tumor activity of dipeptide-alkylated nitrogen-thaliana compounds were revealed, providing direction and guidance for the further design of efficient chemotherapy drugs against osteosarcoma.
Virtual reality set-up for studying vestibular function during head impulse test
Authors: Desoche Clément , Verdelet Grégoire , Salemme Romeo , Farnè Alessandro , Pélisson Denis , Froment Caroline , Hermann Ruben
Published: March 2023

Objectives

Virtual reality (VR) offers an ecological setting and the possibility of altered visual feedback during head movements useful for vestibular research and treatment of vestibular disorders. There is however no data quantifying vestibulo-ocular reflex (VOR) during head impulse test (HIT) in VR. The main objective of this study is to assess the feasibility and performance of eye and head movement measurements of healthy subjects in a VR environment during high velocity horizontal head rotation (VR-HIT) under a normal visual feedback condition. The secondary objective is to establish the feasibility of VR-HIT recordings in the same group of normal subjects but under altered visual feedback conditions.

Design

Twelve healthy subjects underwent video HIT using both a standard setup (vHIT) and VR-HIT. In VR, eye and head positions were recorded by using, respectively, an imbedded eye tracker and an infrared motion tracker. Subjects were tested under four conditions, one reproducing normal visual feedback and three simulating an altered gain or direction of visual feedback. During these three altered conditions the movement of the visual scene relative to the head movement was decreased in amplitude by 50% (half), was nullified (freeze) or was inverted in direction (inverse).

Results

Eye and head motion recording during normal visual feedback as well as during all 3 altered conditions was successful. There was no significant difference in VOR gain in VR-HIT between normal, half, freeze and inverse conditions. In the normal condition, VOR gain was significantly but slightly (by 3%) different for VR-HIT and vHIT. Duration and amplitude of head impulses were significantly greater in VR-HIT than in vHIT. In all three altered VR-HIT conditions, covert saccades were present in approximatively one out of four trials.

Conclusion

Our VR setup allowed high quality recording of eye and head data during head impulse test under normal and altered visual feedback conditions. This setup could be used to investigate compensation mechanisms in vestibular hypofunction, to elicit adaptation of VOR in ecological settings or to allow objective evaluation of VR-based vestibular rehabilitation.
Intake of added sugar, fruits, vegetables, and legumes of Portuguese preschool children: Baseline data from SmartFeeding4Kids randomized controlled trial participants
Authors: Charneca Sofia , Gomes Ana Isabel , Branco Diogo , Guerreiro Tiago , Barros Luísa , Sousa Joana
Published: March 2023

Introduction

The SmartFeeding4Kids (SF4K) program is an online self-guided intervention for parents with the propose of changing parental feeding practices and children’s dietary intake, focusing on the intake of added sugars, fruit, vegetables, and legumes. This paper aims to describe children’s dietary pattern at baseline through a 24-h food recall, the SmartKidsDiet24.

Methods

Overall, 89 participants recorded at least one meal of the 3-day food recall. Mean age was 36.22 ± 6.05 years and 53.09 ± 15.42 months old for parents and children, respectively. Of these, 22 participants were considered to have 2 days of near complete 24-h food recalls. Children’s dietary intake are reported for these 22 participants based on parents reports and, thus, represent estimations only, as it remains unknown whether children consumed other non-reported foods.

Results

Fruit was the group with the highest daily intake among children (mean 1.77 ± 1.10 portions/day), followed by added sugar foods (mean 1.48 ± 0.89 portions/day), vegetables [median 1.27 (1.64) portions/day] and legumes [median 0.12 (0.39) portions/day]. Fruit intake was positively correlated with vegetable intake (p = 0.008). Regarding Dietary Reference Values accomplishment, 13.6% of children exceeded the daily safe and adequate intake of sodium, 77.3% did not meet potassium and fiber recommendations, and 31.8% did not meet vitamin C recommendations.

Discussion

All children did not meet calcium, vitamin B12 and vitamin D intake recommendations. Our findings further justify the need for dietary interventions in this field, to improve young children’s diets.

Clinical trial registration

ClinicalTrials.gov, identifier NCT04591496.
Prognostic role of preoperative inflammatory markers in postoperative patients with colorectal cancer
Authors: Xiao Zilong , Wang Xinxin , Chen Xiaoxiao , Zhou Jiawei , Zhu Haitao , Zhang Jiangnan , Deng Wensheng
Published: March 2023

Background

Inflammatory response markers are prognostic factors for several cancers, but their role in postoperative colorectal cancer (CRC) is unclear. The purpose was to evaluate the role of preoperative Neutrophil-to-Lymphocyte ratio (NLR), Platelet-to-Lymphocyte-ratio (PLR), and Lymphocyte-to-Monocyte ratio (LMR) in the prognosis of postoperative CRC patients.

Methods

We retrospectively reviewed 448 CRC patients who had undergone surgical resection from December 2015 to December 2017 in our hospital. The plasma NLR, PLR, LMR, CEA, and CA19-9 were collected within 2 weeks before the operation. We recorded the clinical characteristics and survival data by reviewing medical records and phone calls. We analyzed preoperative inflammatory markers and clinical features using Pearson chi-squared tests or Fisher’s tests. Uni- and multivariate Cox regression analyses were performed, and overall survival (OS) was estimated with the Kaplan–Meier method.

Results

High NLR and PLR were associated with worse overall survival in postoperative CRC (HR = 2.140, 95%CI = (1.488-3.078), P < 0.001; HR =1.820, 95%CI = (1.271-2.605), P = 0.001). High LMR was associated with improved overall survival in postoperative CRC (HR = 0.341, 95%CI = (0.188-0.618), P < 0.001). In the multivariate regression analysis, the increase of NLR resulted in an increase in the risk of death (HR = 1.678, 95%CI = (1.114-2.527), P = 0.013), and for the LMR, a reduction of the risk of death (HR = 0.480, 95%CI = (0.256 - 0.902), P = 0.023). Moreover, TNM stage, CA-199, CEA, nerve or vascular invasion (NVI) and adjuvant chemotherapy after surgery also were associated with worse overall survival in postoperative CRC.

Conclusion

Current evidence indicates that preoperative inflammatory markers NLR, LMR, and PLR are associated with overall survival in postoperative patients with colorectal cancer. NLR is an independent risk factor, and LMR is an independent protective factor in CRC patients after surgery.
Development and validation of a nomogram model for lung cancer based on radiomics artificial intelligence score and clinical blood test data
Authors: Hu Wenteng , Zhang Xu , Saber Ali , Cai Qianqian , Wei Min , Wang Mingyuan , Da Zijian , Han Biao , Meng Wenbo , Li Xun
Published: March 2023

Background

Artificial intelligence (AI) discrimination models using single radioactive variables in recognition algorithms of lung nodules cannot predict lung cancer accurately. Hence, we developed a clinical model that combines AI with blood test variables to predict lung cancer.

Methods

Between 2018 and 2021, 584 individuals (358 patients with lung cancer and 226 individuals with lung nodules other than cancer as control) were enrolled prospectively. Machine learning algorithms including lasso regression and random forest (RF) were used to select variables from blood test data, Logistic regression analysis was used to reconfirm the features to build the nomogram model. The predictive performance was assessed by performing the receiver operating characteristic (ROC) curve analysis as well as calibration, clinical decision and impact curves. A cohort of 48 patients was used to independently validate the model. The subgroup application was analyzed by pathological diagnosis.

Findings

A total of 584 patients were enrolled (358 lung cancers, 61.30%,226 patients for the control group) to establish the model. The integrated model identified eight potential factors including carcinoembryonic antigen (CEA), AI score, Pro-Gastrin Releasing Peptide (ProGRP), cytokeratin 19 fragment antigen21-1(CYFRA211), squamous cell carcinoma antigen(SCC), indirect bilirubin(IBIL), activated partial thromboplastin time(APTT) and age. The area under the curve (AUC) of the nomogram was 0.907 (95% CI, 0.881-0.929). The decision and clinical impact curves showed good predictive accuracy of the model. An AUC of 0.844 (95% CI, 0.710 - 0.932) was obtained for the external validation group.

Conclusion

The nomogram model integrating AI and clinical data can accurately predict lung cancer, especially for the squamous cell carcinoma subtype.
Targeting tumor immunosuppressive microenvironment for pancreatic cancer immunotherapy: Current research and future perspective
Authors: Li Ying , Xiang Shuai , Pan Wenjun , Wang Jing , Zhan Hanxiang , Liu Shanglong
Published: March 2023

Pancreatic cancer is one of the most malignant tumors with increased incidence rate. The effect of surgery combined with chemoradiotherapy on survival of patients is unsatisfactory. New treatment strategy such as immunotherapy need to be investigated. The accumulation of desmoplastic stroma, infiltration of immunosuppressive cells including myeloid derived suppressor cells (MDSCs), tumor associated macrophages (TAMs), cancer‐associated fibroblasts (CAFs), and regulatory T cells (Tregs), as well as tumor associated cytokine such as TGF-β, IL-10, IL-35, CCL5 and CXCL12 construct an immunosuppressive microenvironment of pancreatic cancer, which presents challenges for immunotherapy. In this review article, we explore the roles and mechanism of immunosuppressive cells and lymphocytes in establishing an immunosuppressive tumor microenvironment in pancreatic cancer. In addition, immunotherapy strategies for pancreatic cancer based on tumor microenvironment including immune checkpoint inhibitors, targeting extracellular matrix (ECM), interfering with stromal cells or cytokines in TME, cancer vaccines and extracellular vesicles (EVs) are also discussed. It is necessary to identify an approach of immunotherapy in combination with other modalities to produce a synergistic effect with increased response rates in pancreatic cancer therapy.
Cartilaginous predictors of residual acetabular dysplasia (RAD) in developmental dysplasia of the hip following closed or open reduction: A systematic review and meta-analysis
Authors: Yang Shuai , Su Fei , Jia Hao-Ruo , Liu Chen-Xin , Lu Qing-Da , Yang Ya-Ting , Liu Yong , Wang Jia-Ju , Jie Qiang
Published: March 2023

Object

This study was designed to analyze the cartilaginous predictors of residual acetabular dysplasia (RAD) after early treatment of developmental dysplasia of the hip and their diagnostic accuracy.

Study design

Databases such as PubMed, Embase, Cochrane, and Web of science were searched to screen the literature. The quality of the literature was assessed by the QUADAS-2 tool. Qualitative and quantitative synthesis of literature were performed based on extracted data. For quantitative synthesis studies, the sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve with corresponding confidence intervals were calculated.

Results

For the cartilaginous acetabular index (CAI) group, the combined values of sensitivity, specificity, and DOR were 0.80 (95% CI = 0.54–0.93), 0.73 (95% CI = 0.57–0.84), and 10.62 (95% CI = 3.96–28.53), respectively. The corresponding values in the cartilaginous center-edge angle (CCE) group were 0.71 (95% CI = 0.57–0.82), 0.78 (95% CI = 0.66–0.87), and 8.64 (95% CI = 3.08–24.25), respectively. The area under the curve (AUC) of SROC was 0.82 (95% CI = 0.78–0.85) and 0.80 (95% CI = 0.76–0.83) for the CAI and CCE groups. The CAI group had higher sensitivity, DOR, and AUC than the CCE group.

Conclusion

Both of these two groups have good diagnostic accuracy, and CAI/L-AI has a little edge over CCE/L-CEA. However, there is still more research needed to determine whether they can be used as independent indications for secondary orthopedic surgery.

Systematic review registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier: [CRD42022338332].
Bacterial growth and ceftriaxone activity in individual ascitic fluids in an in vitro model of spontaneous bacterial peritonitis
Authors: van Os Wisse , Wulkersdorfer Beatrix , Eberl Sabine , Oesterreicher Zoe , Schwabl Philipp , Reiberger Thomas , Paternostro Rafael , Weber Maria , Willinger Birgit , Zeitlinger Markus
Published: March 2023

Introduction: The environment of the infection site affects bacterial growth and antibiotic activity. When bacterial growth and antibiotic activity are studied in body fluids, samples of multiple subjects are usually pooled, averaging out potentially relevant differences in composition. The ascitic fluid (AF) environment is frequently associated with spontaneous bacterial peritonitis (SBP) in cirrhotic patients. In this study, bacterial growth and ceftriaxone activity were evaluated in individual AF using an in vitro model of SBP, reflecting the environment and pharmacokinetics at the infection site.

Methods: AF was obtained from nine cirrhotic patients with non-infected ascites. Growth of nine bacterial strains (three Escherichia coli, four Staphylococcus aureus, one Enterococcus faecalis, and one Klebsiella pneumoniae) in individual AF was assessed and correlated with biomarkers including potential risk factors for SBP. Ceftriaxone time-kill experiments, in which the pharmacokinetic profile observed in AF following a 1 g intravenous infusion was replicated, were performed with two E. coli and two S. aureus isolates with minimum inhibitory concentrations around the ceftriaxone resistance breakpoint.

Results: Significant correlations were found between bacterial growth and AF levels of protein (Spearman’s rank correlation coefficient ρ = −0.35), albumin (ρ = −0.31), and complement C3c (ρ = −0.28), and serum levels of bilirubin (ρ = 0.39) and aspartate aminotransferase (ρ = 0.25). Ceftriaxone was active in AF, even against resistant isolates, generally resulting in ≥2 log reductions in bacterial count within 24 h.

Conclusion: Ascites patients may be predisposed to or protected against SBP based on the antimicrobial capacity of their AF. Ceftriaxone at clinical AF concentrations is active in the AF environment.
Sympathetic feedback cooling in the optomechanical system consisting of two coupled cantilevers
Authors: Gong Zhi-Cheng , Shen Cheng-Yu , Yuan Quan , Sun Chang-Pu , Li Yong , Fu Hao
Published: March 2023

We present sympathetic cooling in an optomechanical system consisting of two coupled cantilevers. The hybridization of the cantilevers creates a symmetric mode, which is feedback cooled, and an anti-symmetric mode not directly controllable by the feedback. The scheme of sympathetic cooling is adopted to cool the anti-symmetric mode indirectly by parametrically coupling to the feedback-cooled symmetric mode, from which the cooling power can be transferred. Experiment shows that the realization of coherent dynamics plays an essential role in sympathetic cooling, in which optimal cooling is achieved when the mechanical dissipation rate and the strength of coupling become comparable. The sympathetic cooling is improved by increasing the strength of mode coupling to enhance the transfer of cooling power. Also, the limit of sympathetic cooling imposed by the capacity of feedback cooling is reached as the effective temperatures of the two modes approach the strong coherent coupling condition. Our research provides the prospect of extending the cooling techniques to coupled mechanical resonators for a broad application in sensing and information processing.
ECMI resonance in AKR revisited: Hyperbolic resonance, harmonics, and wave–wave interaction
Authors: Baumjohann W. , Treumann R. A.
Published: March 2023

Recapitulation of the resonance condition for the fundamental and higher electron cyclotron harmonics in the electron cyclotron maser instability (ECMI) enables radiation below and confirms the possibility of radiation in a narrow band above harmonics n > 1. Near n = 1 resonance on the confined lower X-mode branch, amplification is supported by the decrease in phase and group speeds. Confined slow large-amplitude quasi-electrostatic X-modes non-linearly modulate the plasma to form cavitons until self-trapped inside them at a further increasing wavenumber. They undergo wave–wave interaction, enabling escape into free space in the second harmonic band below n = 2. At a sufficiently large parallel wavenumber (oblique propagation), the fundamental resonance n = 1 is hyperbolic, a possibility so far missed but vital for an effective ECMI in the upward current region. Here, the resonance hyperbola favorably fits the loss-cone boundary, the presumably important ECMI upward-current source-electron distribution, to stimulate ECMI growth at available auroral electron energies.
Genetics and breeding for resistance against four leaf spot diseases in wheat (Triticum aestivum L.)
Authors: Gupta Pushpendra Kumar , Vasistha Neeraj Kumar , Singh Sahadev , Joshi Arun Kumar
Published: March 2023

In wheat, major yield losses are caused by a variety of diseases including rusts, spike diseases, leaf spot and root diseases. The genetics of resistance against all these diseases have been studied in great detail and utilized for breeding resistant cultivars. The resistance against leaf spot diseases caused by each individual necrotroph/hemi-biotroph involves a complex system involving resistance (R) genes, sensitivity (S) genes, small secreted protein (SSP) genes and quantitative resistance loci (QRLs). This review deals with resistance for the following four-leaf spot diseases: (i) Septoria nodorum blotch (SNB) caused by Parastagonospora nodorum; (ii) Tan spot (TS) caused by Pyrenophora tritici-repentis; (iii) Spot blotch (SB) caused by Bipolaris sorokiniana and (iv) Septoria tritici blotch (STB) caused by Zymoseptoria tritici.
Comprehensive metabolomic and lipidomic alterations in response to heat stress during seed germination and seedling growth of Arabidopsis
Authors: Qian Wenjuan , Zhu Yuxuan , Chen Qinsheng , Wang Shuaiyao , Chen Longlong , Liu Ting , Tang Huiru , Yao Hongyan
Published: March 2023

Temperature affects seed germination and seedling growth, which is a critical and complex stage in plant life cycle. However, comprehensive metabolic basis on temperature implicating seed germination and seedling growth remains less known. Here, we applied the high-throughput untargeted metabolomic and advanced shotgun lipidomic approaches to profile the Arabidopsis 182 metabolites and 149 lipids under moderate (22°C, 28°C) and extreme high (34°C, 40°C) temperatures. Our results showed that a typical feature of the metabolism related to organic acids/derivates and amines was obviously enriched at the moderate temperature, which was implicated in many cellular responses towards tricarboxylic acid cycle (TCA), carbohydrates and amino acids metabolism, peptide biosynthesis, phenylpropanoid biosynthesis and indole 3-acetate (IAA) biosynthetic pathway. Whereas, under extreme high temperatures, there was no seed germination, but 148 out of total 182 metabolites were highly enriched, involving in the galactose metabolism, fatty acid degradation, tryptophan/phenylalanine metabolism, and shikimic acid-mediated pathways especially including alkaloids metabolism and glucosinolate/flavone/flavonol biosynthesis. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) also exhibited the gradually increased tendency from moderate temperatures to extreme high temperatures; whereas phosphatidylserine (PS), phosphatidic acid (PA), phosphatidylglycerol (PG), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and sulfoquinovosyldiacylglycerol (SQDG) were contrary to decrease. Another typical feature of the distinguished metabolites between 22°C and 28°C, the TCA, disaccharides, nucleotides, polypeptides, SQDG and the biosynthesis of fatty acids and glucobrassicin-mediated IAA were obviously decreased at 28°C, while amino acids, trisaccharides, PE, PC, PA, PS, MGDG, DGDG and diacylglycerol (DAG) preferred to enrich at 28°C, which characterized the alteration of metabolites and lipids during fast seedling growth. Taking together, our results provided the comprehensive metabolites phenotyping, revealed the characteristics of metabolites necessary for seed germination and/or seedling growth under different temperatures, and provided insights into the different metabolic regulation of metabolites and lipid homeostasis for seed germination and seedling growth.
Inclusive physical activity games at school: The role of teachers’ attitude toward inclusion
Authors: Gentile Ambra , Giustino Valerio , Rodriguez-Ferrán Olga , La Marca Alessandra , Compagno Giuseppa , Bianco Antonino , Battaglia Giuseppe , Alesi Marianna
Published: March 2023

Introduction

Inclusive physical activity games at school can be useful for teachers dealing with students with disabilities. The use of inclusive strategies and games can be directly linked to teachers’ self-efficacy and familiarity with the inclusive strategies, while it could be indirectly influenced by their attitude toward inclusion and, in a smaller part, by social desirability in their response. Moreover, teachers’ responses could be different among the different school grades. Therefore, the aim of the current study is to investigate the role of attitude toward inclusion, social desirability, self-efficacy, and familiarity in the use of physical activity games at school in teachers from all school grades.

Methods

A sample of 1,583 schoolteachers was asked to fill out a questionnaire about their perceptions of governmental measures, self-efficacy, familiarity with inclusive strategies through physical activity, and two standardized questionnaires assessing attitudes toward inclusion and social desirability.

Results

Teachers from primary school reported lower scores in attitude toward inclusion total score and dimensions, namely impact on teacher, impact on the environment, impact on the other children, and impact on the student with disability. Moreover, the path analysis model showed that the attitude toward inclusion indirectly influenced the use of inclusive strategy and had a small direct effect on familiarity with inclusive strategies and self-efficacy. Social desirability slightly influenced both familiarity and self-efficacy but not the use of inclusive strategies. Familiarity and self-efficacy had a direct effect on the use of inclusive physical activity games.

Discussion

The results of the current study suggest that being familiar with and having a high self-efficacy in implementing inclusive strategies are well related to the use of inclusive strategies at school. In addition, more attention should be given to kindergarten and primary school teachers, who reported lower scores in the attitude toward inclusion and higher scores in social desirability.
Global narratives on unequal outcomes produced by lockdown in Africa: A social science perspective on the “one-size-fits all” COVID-19 response
Authors: Grant Catherine , Sams Kelley
Published: March 2023

Introduction

Lockdown measures were introduced worldwide to prevent the spread of COVID-19, and several studies showed the positive impacts of these policies in places such as China and Europe. Many African governments also imposed lockdowns at the beginning of the pandemic. These lockdowns met with mixed reactions; some were positive, but others focused on concerns about the consequences of lockdowns.

Methods

In this article, we use social listening to examine social media narratives to investigate how people balanced concerns about preventing the spread of COVID-19 with other priorities. Analyzing social media conversations is one way of accessing different voices in real time, including those that often go unheard. As internet access grows and social media becomes more popular in Africa, it provides a different space for engagement, allowing people to connect with opinions outside of their own conceptual frameworks and disrupting hierarchies of how knowledge is shaped.

Results

This article indicates which narratives were favored by different organizations, stakeholders, and the general public, and which of these narratives are most dominant in policy discourses. The range of narratives is found to be reflective of the blindness to inequality and social difference of much decision-making by policymakers.

Discussion

Thus, contrary to the “we are all in this together” narrative, diseases and public health responses to them clearly discriminate, accentuating long-standing structural inequalities locally, nationally, and globally, as well as interplaying with multiple, dynamic, and negotiated sources of marginalization. These and other insights from this article could play a useful role in understanding and interpreting how social media could be included in pandemic preparedness plans.
A mixed methods approach to obtaining health care provider feedback for the development of a Canadian pediatric dental caries risk assessment tool for children <6 years
Authors: Schroth Robert J. , Kyoon-Achan Grace , Levesque Josh , Sturym Melina , DeMaré Daniella , Mittermuller Betty-Anne , Lee Juyoung , Lee Victor Ho Kong
Published: March 2023

Introduction

Early childhood caries (ECC) is a chronic but preventable disease affecting young children worldwide. Many young children face access to care barriers to early preventive dental visits for a variety of reasons, which can increase their risk for ECC. Non-dental primary health care providers are well positioned to assist in assessing a child's risk for ECC by performing caries risk assessment (CRA). The purpose of this project was to report on primary health care provider and stakeholder feedback in order to refine a drafted CRA tool for Canadian children <6 years of age intended for use by non-dental primary health care providers.

Methods

In this mixed methods project, we conducted six focus groups with primarily non-dental primary health care providers followed by a short paper-based survey to quantify preferences and feedback. Data were thematically and descriptively analyzed.

Results

Participants’ feedback on the drafted CRA tool included the need for it to be relatively quick to complete, easy and practical to score, easy to implement into practitioners’ clinic schedules, and to include anticipatory guidance information to share with parents and caregivers. All participants (100%) welcomed a CRA tool. Many (85.4%) liked a layout that could be added to tools they already utilize. Most (73.2%) wanted the tool to be in colour, and many (90.2%) wanted the tool to include pictures.

Conclusion

Non-dental primary health care providers informed the final development and layout of the newly released Canadian CRA tool. Their feedback resulted in a user-friendly CRA tool with provider-patient dynamics and preferences.
Relationship between edema and intracranial pressure following intracerebral hemorrhage in rat
Authors: Kalisvaart Anna C. J. , Bahr Natasha A. , Colbourne Frederick
Published: March 2023

Elevated intracranial pressure (ICP) is a potentially fatal consequence of intracerebral hemorrhage (ICH). As the mass of the hematoma and regional edema builds, ICP rises and becomes increasingly variable acutely after stroke. High ICP may worsen cellular injury and edema by impairing local tissue perfusion, fueling a cycle that may ultimately cause fatality through ischemia and brain herniation. Time spent above an ICP of 20 mmHg often predicts a greater risk of death and disability following ICH. Compensatory mechanisms combat rising ICP. Classically, these include cerebrospinal fluid volume loss and cerebrovascular autoregulation, such as a reduction in the volume of venous blood. Additional mechanisms such as brain tissue compliance and skull volume compensation may also contribute. Compensatory compliance mechanisms are limited, and they vary by age and many other factors. Animal models of ICH are widely used to assess these variables and to gauge putative therapeutics. Most often those studies rely upon simple measures of edema, which may not accurately predict ICP data. Thus, we analyzed our past studies characterizing ICP, edema, and tissue compliance responses to striatal ICH in rat, including the collagenase (C-ICH) and whole blood models (WB-ICH). We found that both ICH models raised ICP, with greater effects in the C-ICH model, which may thus better reflect clinical findings of concern. Importantly, measures of edema, such as in the damaged hemisphere, on their own are not predictive of average or peak ICP response within either model, unless assessing across a very wide range of injury severities, or when including non-stroke animals. We caution against using edema data as a surrogate measure of mass effect and ICP following ICH.
Smallholder livelihood resilience to climate variability in South-Eastern Kenya, 2012–2015
Authors: Aschinger Roman , Boillat Sébastien , Ifejika Speranza Chinwe
Published: March 2023

Climate change, land degradation, demographic change and persistent poverty pose major challenges to smallholder farmers in the arid and semi-arid lands of sub-Saharan Africa. Though many studies have focused on how resilient these households are to shocks, very few studies deal with how household resilience varies over time. We provide a longitudinal analysis to assess how the resilience of smallholder households in south-eastern Kenya has varied from 2012 to 2015. We use the Livelihood Resilience Indicator Framework to examine the linkages between livelihood outcomes and livelihood resilience (buffer capacity, self-organization and capacity for learning). We collected data from 134 households on three resilience dimensions: buffer capacity, self-organization, and capacity for learning. We performed principal component analysis to identify the key components of these dimensions and examine their relevance for livelihood outcomes. Our findings show that under drought conditions in 2012, conservation agriculture practices significantly contributed to maize yields. In both years 2012 and 2015, there was a positive correlation between resilience dimensions and food security. Key components of this relation were land area, income, conservation agriculture practices, climate forecasts and actions taken for the upcoming growing season.
Duodenum-preserving pancreatic head resection compared to pancreaticoduodenectomy: A systematic review and network meta-analysis of surgical outcomes
Authors: Guo Shixiang , Zhou Qiang , Yang Jiali , Tao Junyu , Zhang Junfeng , Wang Huaizhi
Published: March 2023

Objectives

In this systemic review and network meta-analysis, we investigated pancreaticoduodenectomy (PD), pylorus-preserving pancreaticoduodenectomy (PPPD), and different modifications of duodenum-preserving pancreatic head resection (DPPHR) to evaluate the efficacy of different surgical procedures.

Methods

A systemic search of six databases was conducted to identify studies comparing PD, PPPD, and DPPHR for treating pancreatic head benign and low-grade malignant lesions. Meta-analyses and network meta-analyses were performed to compare different surgical procedures.

Results

A total of 44 studies were enrolled in the final synthesis. Three categories of a total of 29 indexes were investigated. The DPPHR group had better working ability, physical status, less loss of body weight, and less postoperative discomfort than the Whipple group, while both groups had no differences in quality of life (QoL), pain scale scores, and other 11 indexes. Network meta-analysis of a single procedure found that DPPHR had a larger probability of best performance in seven of eight analyzed indexes than PD or PPPD.

Conclusion

DPPHR and PD/PPPD have equal effects on improving QoL and pain relief, while PD/PPPD has more severe symptoms and more complications after surgery. PD, PPPD, and DPPHR procedures exhibit different strengths in treating pancreatic head benign and low-grade malignant lesions.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, identifier: CRD42022342427.
Characteristics of the paravertebral muscle in adult degenerative scoliosis with PI-LL match or mismatch and risk factors for PI-LL mismatch
Authors: Guo Jichao , Xie Dongxiao , Zhang Jinniu , Ding Wenyuan , Zhao Boyang , Li Zhaohui , Huo Yachong
Published: March 2023

Objective

Pelvic incidence (PI) minus the lumbar lordosis (LL) angle (PI-LL) correlates with function and disability. It is associated with paravertebral muscle (PVM) degeneration and is a valuable tool for surgical planning of adult degenerative scoliosis (ADS). This study aims to explore the characteristics of PVM in ADS with PI-LL match or mismatch and to identify the risk factors for PI-LL mismatch.

Methods

A total of 67 patients with ADS were divided into PI-LL match and mismatch groups. The visual analog scale (VAS), symptom duration, and Oswestry disability index (ODI) were used to assess patients’ clinical symptoms and quality of life. The percentage of fat infiltration area (FIA%) of the multifidus muscle at the L1-S1 disc level was measured by using MRI with Image-J software. Sagittal vertical axis, LL, pelvic tilt (PT), PI, sacral slope, and the asymmetric and average degeneration degree of the multifidus were recorded. Logistic regression analysis was done to identify the risk factors for PI-LL mismatch.

Results

In the PI-LL match and mismatch groups, the average FIA% of the multifidus on the convex side was less than that on the concave side (P < 0.05). There was no statistical difference of asymmetric degeneration degree of the multifidus between the two groups (P > 0.05). In the PI-LL mismatch group, the average degeneration degree of the multifidus, VAS, symptom duration, and ODI were significantly higher than that in the PI-LL match group, respectively (32.22 ± 6.98 vs. 26.28 ± 6.23 (%), 4.33 ± 1.60 vs. 3.52 ± 1.46, 10.81 ± 4.83 vs. 6.58 ± 4.23 (month), 21.06 ± 12.58 vs. 12.97 ± 6.49, P < 0.05). The average degeneration degree of the multifidus muscle was positively correlated with the VAS, symptom duration, and ODI, respectively (r = 0.515, 0.614, and 0.548, P < 0.05). Sagittal plane balance, LL, PT, and the average degeneration degree of the multifidus were the risk factors for PI-LL mismatch (OR: 15.447, 95% CI: 1.274–187.269; OR: 0.001, 95% CI: 0.000–0.099; OR: 107.540, 95% CI: 5.195–2,225.975; OR: 52.531, 95% CI: 1.797–1,535.551, P < 0.05).

Conclusion

The PVM on the concave side was larger than that on the convex side in ADS irrespective of whether PI-LL matched or not. PI-LL mismatch could aggravate this abnormal change, which is an important cause of pain and disability in ADS. Sagittal plane imbalance, decreased LL, higher PT, and larger average degeneration degree of the multifidus were independent risk factors for PI-LL mismatch.
Fair Value of Retail Loans: Are We Following IFRS9 or Misinterpreting It?
Authors: Gulyás Éva , Rátky Márton Miklós
Published: March 2023

This study examines the accounting treatment applied to retail loans using a multiplication factor of 1.3. Answers are sought to the following questions: What is the correct IFRS accounting treatment of loans with a 1.3 multiplication factor in their interest rate, which have appeared in the Hungarian banking sector since 2016? Does the sector report these loans correctly? Is there a possibility for substancebased accounting treatment? How does the different accounting treatment of identical loan types affect the comparability of banks’ financial statements? After discussing the results from the literature and presenting the main features of the loans under review, the methodology of the study is described, before turning to the dilemmas and consequences of the accounting treatment. In this context, the IFRS requirements applicable when choosing the measurement principle for the loans concerned are also analysed. After drawing the conclusions, the paper argues in favour of measurement at amortised cost.