bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation Skills Assessment: A Cross-sectional Approach to Benchmarking Innovation Potential among Employees of a Tertiary Care Hospital in Pakistan
Authors: Tahir Hasan Nawaz , Sajid Haseeb , Sulaiman Mahreen , Raheem Ahmed , Khan Irfan , Ahsan Zeeshan , Mian Asad I.
Published: September 2023

Background: Health innovation can play a critical role in the socio-economic development of a nation. Healthcare organizations may claim to be innovative in their implementation of clinical care, but they lack an objective low cost and easy-to-use measure of their innovation capacity. Innovation dashboarding through a relevant tool may fill that gap.
Purpose:To facilitate low-cost, low-tech, and fast-tracked innovation by profiling the following four parameters at a tertiary care hospital in Pakistan: (I) low-cost innovative idea generation; (II) risk behavior ‘(III) relationship development; and (IV) pivoting from an idea to a tangible product.
Methods: This cross-sectional descriptive study included employees from a tertiary care hospital in the southern Punjab district of Pakistan, using non-probability purposive sampling. The study tool, the Innovation Skills Assessment (ISA), is a novel questionnaire adapted from the validated General Innovation Skills Aptitude Test 2.0. The ISA has structured closed-ended questions, focusing on four pillars of innovation: Pillar I - generating ideas, Pillar II - taking calculated risks and being entrepreneurial, Pillar III - developing and maintaining interpersonal relationships, and Pillar IV- turning ideas into products, processes, and services.
Results:Stratification of the 161 participants (60% males) into various age groups revealed that individuals aged 36 to 45 years had the highest scores (mean of 4.48) across all four pillars, outperforming other age groups. Additionally, male participants scored higher than females in Pillars I to IV. Participants with education up to the high school level exhibited the highest innovation scores for Pillars I, II, and IV.
Conclusion: The ISA can assess healthcare organizational innovation capabilities to establish a baseline. The age group of 36 to 45 emerges as a pivotal period for fostering a healthcare innovation-driven culture in LMICs like Pakistan. The ISA's insights may guide tailored strategies, driving impactful health innovation globally.
MESH TERMS: Hospital Innovation, creativity, entrepreneurship, innovation dashboarding, innovation skills, innovation benchmarking, health service delivery, health system, South Asia, LMIC.
Précis:This cross-sectional study utilized the Innovation Skills Assessment tool to analyze idea generation, risk-taking behavior, and the ability to pivot ideas to products among employees in a tertiary care hospital in Pakistan. The findings emphasize the importance of the 36 to 45 years age group in leading the innovation culture and stress the need for evaluating low-cost innovative programs for effectiveness.
A novel method to monitor rheumatoid arthritis prevalence using hospital and medication databases
Authors: Koller-Smith Louise , Mehdi Ahmed , March Lyn , Tooth Leigh , Mishra Gita D. , Thomas Ranjeny
Published: September 2023

Background
Most estimates of rheumatoid arthritis (RA) prevalence, including all official figures in Australia and many other countries, are based on self-report. Self-report has been shown to overestimate RA, but the ‘gold standard’ of reviewing individual medical records is costly, time-consuming and impractical for large-scale research and population monitoring. This study provides an algorithm to estimate RA cases using administrative data that can be adjusted for use in multiple contexts to provide the first approximate RA cohort in Australia that does not rely on self-report.
Methods
Survey data on self-reported RA and medications from 25 467 respondents of the Australian Longitudinal Study on Women’s Health (ALSWH) were linked with data from the national medication reimbursement database, hospital and emergency department (ED) episodes, and Medicare Benefits codes. RA prevalence was calculated for self-reported RA, self-reported RA medications, dispensed RA medications, and hospital/ED RA presentations. Linked data were used to exclude individuals with confounding autoimmune conditions.
Results
Of 25 467 survey respondents, 1367 (5·4%) women self-reported disease. Of the 26 840 women with hospital or ED presentations, 292 (1·1%) received ICD-10 codes for RA. There were 1038 (2·8%) cases by the medication database definition, and 294 cases (1·5%) by the self-reported medication definition. After excluding individuals with other rheumatic conditions, prevalence was 3·9% for self-reported RA, 1·9% based on the medication database definition and 0·5% by self-reported medication definition. This confirms the overestimation of RA based on self-reporting.
Conclusions
We provide an algorithm for identifying individuals with RA, which could be used for population studies and monitoring RA in Australia and, with adjustments, internationally. Its balance of accuracy and practicality will be useful for health service planning using relatively easily accessible input data.
Combining transfer learning and hyperspectral imaging to identify bruises of pears across different bruise types
Authors: Liu Dayang , Zhang Huiting , CongCong Wang , Lv Feng , Yanrong Tao , Zhu Liangkuan
Published: September 2023

Background
Mechanical bruise is one of the most crucial factors affecting the quality of pears, which has a huge influence on postharvest transportation, storage, and sale of pears. To rapidly detect early bruises of pears across different bruise types, hyperspectral imaging technology coupled with transfer learning methods was performed in this study.
Results
Two transfer learning methods, i.e., transfer component analysis (TCA) and manifold embedded distribution alignment (MEDA), were applied for two tasks (impact bruise → crush bruise, crush bruise → impact bruise). Supporting vector machine (SVM) was set as a baseline to conduct analysis and comparison of the transferability of the models. The result showed that, for task 1 (impact bruise → crush bruise), MEDA and TCA-SVM model achieved a classification accuracy of 93.33% and 91.11% in target domain, individually. For task 2 (crush bruise → impact bruise), MEDA and TCA-SVM model achieved an accuracy of 88.89% and 85.19% in target domain, respectively. Both of the two models improved the accuracy compared with SVM models (84.44% for task 1; 77.04% for task 2).
Conclusion
Overall, the results indicated that transfer learning approaches could perform pear bruise detection across different bruise types. Hyperspectral imaging in combination with transfer learning methods is a promising possibility for the efficient and cost-saving field detection of fruit bruises among different bruise types.
Network preservation analysis to identify transcriptional biomarkers related to flowering in Crocus sativus
Authors: Eshaghi Mahsa , Rashidi-Monfared Sajad
Published: September 2023

Crocus sativus L. is known as an ornamental geophyte and a source of valuable spice and secondary metabolites. Network preservation module analysis is one of the best approaches to revealing special features of different conditions. It can determine patterns of divergence and conservation between transcriptome data. Herein, we explored the regulatory genes of the flowering process by RNA-Seq data containing flowering and non-flowering samples in gene expression profiles. Persevered module analysis revealed three significant non-persevered modules related to the flowering process, namely pink, green, and blue. Several hub genes associated with non-preserved modules such as PIA1, NAC90, ALY3, Sus3, MYB31, ARF5/MP, MYB31, HD-ZIP, SEP3d, OR_B, AGL6a, bZIP(TGA1) and GRAS were identified. These candidate genes can be considered key diagnostic biomarkers for the flowering process. Here, we also compare two approaches, WGCNA and NetRep for module preservation analysis. Totally, the results of these methods were consistent with non-preserved modules. NetRep was a faster (11 times) and more efficient (run more than 10000 permutations for each comparison) method than WGCNA module preservation. Differential expression genes (DEGs) screening showed that many hub genes were downregulated in non-flowering than flowering samples. Our finding revealed regulatory mechanisms of the flowering process in C. sativus as can be developed transcriptional biomarkers which could pave the way for promoting saffron yield via flowering induction.
Applications of Geospatial Technology and Water Quality Index in The Assessment of Groundwater Quality
Authors: MACHIREDDY SUNANDANA REDDY , B Bhargava , B Chennapa
Published: September 2023

Groundwater is one of the naturally occurring resources, which is valuable and essential for water supply to the nations. To come across the demand rate it is pivotal to recognize the water resources. Groundwater Quality has direct implication for domestic industrial and drinking purpose. The Water Quality Index is the most productive to collaborate the information of water quality. The objective of the research work is to assess and prepare the spatial distribution maps of groundwater quality of Nandyal Mandal by using geographical information system techniques. This research work is deliberated to evaluate the Water Quality Index of the project area. The Water Quality Index of the study explains overall quality of certain locations based on several physico-chemical parameters with the help of spatial distribution of geographic information system applications. Water samples were collected and tested for several physico-chemical parameters like pH, TDS, Chlorides, Total alkalinity, Total Hardness, Electro Conductivity and Dissolved oxygen.
S100A8 enhances development of glioblastoma by activation of ANXA1- mediated NF-κB pathway
Authors: Da Zheng , Zhou Yeming , Xu Jie , Zhi Zhongwen , Chen Rui
Published: September 2023

Background
Glioblastoma (GBM) is one of the most malignant tumors of human. S100A8 has emerged as vital mediators in cancer. However, the expression and function of S100A8 in GBM and the mechanism involved were unclear.
Methods
The expression of S100A8 was detected in glioma tissue by CGGA, TCGA database and clinical sample. CCK-8, Edu, and Colony information were used to detect cell proliferation. Wound healing and Transwell assays were used to detect cell migration and invasion, respectively. We used Xenograft model to observe the effect of S100A8 on tumor growth in vivo. Finally, immunoblotting and related biological experiments were used to detected the mechanism of S100A8 regulating the development of GBM.
Results
We reported that S100A8 was upregulated in GBM tissues and cells, and S100A8 expression level was correlated with the survival time of GBM patients. Knockdown S100A8 in U87 promoted the cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT), whereas ectopic expression of S100A8 in LN229 decreased these activities of GBM. We also showed that knockdown S100A8 decreased tumor growth of GBM in vivo, and induced survival time of mice with GBM. Mechanistically, we found that S100A8 interacted with ANXA1, and decreased ubiquitination and degradation of ANXA1, thereby inducing NF-κB activation.
Conclusion
This study indicated that S100A8 promoted the development of GBM via ANXA1/NF-κB pathway, suggesting that S100A8 was a potential therapeutic target for GBM.
Spatiotemporal characteristics of drought in the Nanpan River Basin, Yunnan Province, China, from 1956 to 2016
Authors: Hu Fenglin , Yu Hang , Pan Mengnan , Pei Ding , Yang Rui , Wang Long
Published: September 2023

Investigating the spatiotemporal characteristics of drought is crucial for developing effective water resource and drought risk management strategies throughout basins. In this study, PCA, run theory, the MK test, and KORE and EEMD methods were used to systematically explore the spatiotemporal characteristics of drought in the Nanpan River Basin in Yunnan, China, based on the SPI6 series of 33 stations over 61 years. The results indicated that: (1)The Nanpan River Basin to be divided into three homogeneous regions (northern, southwestern and southeastern areas). The drought duration varied among the three subregions and was the shortest (5.30 months) in the southwestern region and the longest (6.25 months) in the southeastern region. The drought magnitude was similar in the different subregions (approximately − 4.0).(2)The long-term drought variation trend showed that the Nanpan River Basin became drier over the studied period. The variation trends of drought duration and drought magnitude in the same subregion were similar. In the southeastern region, the drought duration significantly increased whereas the drought magnitude apparently decreased. There were no obvious trends in the drought duration and magnitude in the northern and southwestern regions.(3)Over the 61 years, the drought yearly occurrence rate showed an overall upward trend, indicating that the frequency of drought events with a moderate drought and above in the Nanpan River Basin increased, even though the drought yearly occurrence rate in the three homogeneous regions fluctuated in different periods.(4)The drought cycles in the Nanpan River Basin were mainly less than 10a, and the quasi-cycles in the three subregions were all 3a; these results passed the significance test at the 80% confidence level. On a period scale of more than 10a, only the southwestern region showed quasi-15a and quasi-31a cycles, which passed the significance test at the 95% and 90% confidence levels, respectively.
Development of risk prediction nomogram for neonatal sepsis in Group B Streptococcus-colonized mothers: A retrospective study
Authors: Wu MengQi , Luo XiaoMing , Deng YanBing , Wang XinYe , He BaoMei , Wei FangQiang , Zhang Ying
Published: September 2023

Background
Neonatal clinical sepsis is recognized as a significant health problem, This study sought to identify a predictive model of risk factors for clinical neonatal sepsis.
Methods
From October 2018 to April 2023, a retrospective study of maternal-newborn dichotomy was conducted in a large tertiary hospital in China. Neonates were divided into patients and controls according to whether neonatal sepsis occurred. A multivariable model was used to determine risk factors and construct models.
Results
A total of 339 pairs of mothers and their newborns were included in the study and divided into two groups: patients (n = 84, 24.78%) and controls (n = 255, 75.22%). Logistic regression analysis was performed to examine the relationship between various factors and outcome. The results showed that maternal age ＜26 years (odds ratio [OR] = 2.16, 95% confidence interval [CI] 1.06–4.42, p = 0.034), maternal gestational diabetes (OR 2.17, 95%CI 1.11–4.27, p = 0.024), no forceps assisted delivery (OR 0.21, 95%CI 0. 05–0.80, p = 0.023 ), no umbilical cord winding (OR 0.57, 95%CI 0.34–0.98, p = 0.041 ) and male neonatal sex (OR 1.59, 95%CI 1.00–2.62, p = 0.050 ) were identified as independent factors influencing the outcome of neonatal clinical sepsis. A main effects model was developed incorporating these five significant factors, resulting in an area under the curve (AUC) value of 0.71 (95% CI: 0.63–0.77) for predicting the occurrence of neonatal clinical sepsis.
Conclusion
A main effects model incorporating the five significant factors was constructed to help healthcare professionals make informed decisions and improve clinical outcomes.
STIM2 is involved in the regulation of apoptosis and cell cycle in normal and malignant monocytic cells
Authors: Djordjevic Stefan , Itzykson Raphaël , Hague Frederic , Lebon Delphine , Legrand Julien , Ouled-Haddou Hakim , Jedraszak Guillaume , Harbonnier Juliette , Collet Louison , Paubelle Etienne , Marolleau Jean-Pierre , Garçon Loïc , Boyer Thomas
Published: September 2023

Background
Calcium is a ubiquitous messenger that regulates a wide range of cellular functions including proliferation, cell migration and apoptosis. Abnormal expression of proteins involved in Ca2+ signaling has been associated with oncogenesis in many solid tumor models. However, its involvement in the pathophysiology of acute myeloid leukemia is less investigated. In this work, we aimed to identify actors of Ca2+ signaling involved in leukemogenesis.
Methods
From an analysis of TCGA and GTEx databases, we identified STIM2, a key sensor regulating Ca2+ capacitive entry, as highly expressed in AML with monocytic differentiation and negatively correlated with overall survival. This was confirmed on a validation cohort of 407 AML patients, showing an association of a high STIM2 expression with adverse risk group according to ELN17 classification. We then investigated the role of STIM2 in cell proliferation, differentiation and survival by modulating its expression in two leukemic cell lines with monocytic potential and in normal hematopoietic stem cells driven into monocytic differentiation.
Results
STIM2 expression increased at the RNA and protein levels upon monocyte differentiation. Phenotypically, STIM2 knockdown drastically inhibited cell proliferation and induced genomic stress with DNA double-strand breaks, as shown by increased p-H2AXγ, followed by activation of the p53 pathway, decreased expression of cell cycle regulators such as CDK1-cyclin B1 and the CDC25c phosphatase, and a decreased apoptosis threshold with a low antiapoptotic/proapoptotic protein ratio. This phenotype was not observed in two p53-deleted cell lines, HL60 and K562. Using a model of in vitro monocytic differentiation of peripheral blood-derived CD34+ cells, we observed higher STIM2 expression at the RNA level in differentiated cells. The acquisition of monocytic markers was faster after STIM2 forced expression, while STIM2 knockdown impaired CD14 expression and led to p-H2AXγ, p53 induction, apoptosis and cell cycle blockage, in agreement with data observed in leukemic cell lines.
Conclusions
In summary, we report STIM2 as a new actor regulating genomic stability and p53 response in terms of cell cycle and apoptosis of human normal and malignant monocytic cells. Considering the association of high STIM2 expression with an adverse prognosis in AML and the association of STIM2 with AML harboring monocytic/myelomonocytic differentiation.
Corruzione fra privati nel settore immobiliare - il «caso poco grave»
Authors: Teichmann Fabian , Gaffuri Dimitri
Published: September 2023

Sulla base di un esempio, gli autori trattano del fenomeno della corruzione fra privati (art. 322octies seg. CP) sul mercato immobiliare. In particolare, sono messe in risalto le problematicità legate all'art. 322octies cpv. 2 rispettivamente all'art. 322novies cpv. 2 CP, secondo cui il reato è perseguibile solo a querela di parte nei casi poco gravi. Tale distinzione, che costituisce un unicum all'interno del diritto penale svizzero, può portare a situazioni in cui la corruzione fra privati risulta punibile ai sensi di altre norme del Codice penale, ma non della normativa specifica.

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Sur la base d'un exemple, les auteurs traitent du phénomène de la corruption privée (art. 322octies ss CP) sur le marché de l'immobilier. Ils soulignent en particulier les problèmes liés à l'art. 322octies al. 2 et art. 322novies al. 2 CP, selon lesquels l'infraction n'est poursuivie que sur plainte dans les cas de peu de gravité. Cette distinction, unique en droit pénal suisse, peut conduire à des situations où la corruption privée est certes punie par les dispositions relatives aux infractions contre le patrimoine, mais pas par les art. 322octies ss CP pourtant prévus à cet effet.

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Auf Grundlage eines Beispiels erörtern die Autoren das Phänomen der Privatbestechung (Art. 322octiesff. StGB) im Immobiliensektor. Sie beleuchten insbesondere die Problematik, die daraus ensteht, dass das Delikt in einfachen Fällen nur auf Antrag verfolgt wird. Diese im schweizerischen Strafrecht einmalige Konstellation kann dazu führen, dass eine Bestechung zwischen Privatpersonen zwar nach den Bestimmungen des Vermögensstrafrechts strafbar ist, nicht aber nach den eigentlich dafür vorgesehenen korrputionsstrafrechtlichen Art. 322octiesff. StGB.
A Multi-Geochemical Characterization to Evaluate Anthropogenic Contamination in Marine Sediments from Port of Suape, Northeast of Brazil
Authors: de Oliveira Ana Flávia , Gomes Bruna , França Rebeca , Moreira Thayane Cristina , Moraes Alex , Bataglion Giovana , Santos Jandyson
Published: September 2023

To investigate the anthropogenic contamination of the Port of Suape, five surface sediments were collected and subjected to a geochemical characterization based on the determination of environmental biomarkers such as sterols, aliphatic and polycyclic aromatic hydrocarbons, and also metals and arsenic. Sterol analyses point to a moderate level of sewage contamination, while n-alkanes analyses indicated contamination by petroleum in an early stage of biodegradation. Polycyclic aromatic hydrocarbons analyses pointed to a mixture of contributions for the organic matter, which were predominantly found for petrogenic and pyrolytic sources. The quantification of trace metals indicated a low risk to the environment, except for As, which was identified as displaying moderate contamination. During the analysis of all biomarkers, the sediment collected near one of the shipyards was the most affected. These results enable comprehension of the level of contamination in an important Brazilian port and the need to develop remediation policies.
Management of Money Issue
Authors:   Institute of State and Law of the Russian Academy of Sciences, Vasyanina E. L.
Published: September 2023

The article discusses the legal aspects of money issue management, examines the economic and legal issues of the use of monetary and budgetary policy instruments. It is proved that the Central Bank of the Russian Federation is not the only regulator of monetary emission, and the list of means of managing the process of creating the solvency of participants in civil turnover is not limited to the provisions of the Federal Law "On the Central Bank of the Russian Federation (Bank of Russia)". In addition to the banking system, the budget system participates in the creation of the solvency of economic entities, and the issue of the budget ruble is mediated by a budgetary and legal mechanism. In addition, in the conditions of the modern model of public administration, financial institutions of development play an active role in the management of monetary emission. The use of general logical research methods, including analysis and synthesis, formal legal and comparative legal methods allowed the author to come to the following conclusions: 1) the empowerment of financial development institutions with the authority to allocate budget funds, loans, and in fact the authority to determine the conditions for the emergence and fulfillment of emission financial obligations led to the creation of an alternative legal institution for regulating the process of transferring money to the economy, bypassing the banking and budgetary system; 2) the activation of the process of transferring part of the functions of the Bank of Russia to the Government of the Russian Federation in the context of an unprecedented sanctions regime against Russia will have a positive impact on the formation of a modern legal model of money issue management, since it will limit the independence of the Central Bank of the Russian Federation fulfilling obligations arising from the Articles of the IMF Agreement.
Toleration and Tolerance as Human Challenges: The Voice of an Eighteenth-Century Dramatist, Gotthold Ephraim Lessing, for the Twenty-First Century
Authors:   University of Arizona, Editor-in-Chief, Humanities, MDPI, and Editor-in-Chief, Mediaevistik, Classen Albrecht
Published: September 2023

In light of countless problems, the modern world faces, especially religious fanaticism, violence, and hatred, it is high time to reflect on some of the older literary statements once again that had already voiced critical concerns about the principles of human interaction determined by good communication, love, and tolerance. Maybe surprisingly, when we turn to Lessing’s Nathan der Weise (1779), we come across a major literary document in which those ideals are formulated convincingly and dramatically. While German scholarship has already discussed this play for a long time, it deserves much wider attention because of its strong advocation of those ideals, which we are in the highest need as of today.
Effect of Sustainable Development and Institutional Quality on Growth
Authors: Har Wai Mun , Sin Mei Chen
Published: September 2023

The issue of compatibility of sustainable development policies, institutional quality, and economic growth gains on importance as the world races towards achieving the 2030 Agenda for Sustainable Development. This paper aims to examine the relationship between sustainable development, institutional quality, and economic growth between the years 2012 and 2021 in 116 countries. The quantile regression method has been employed in this study to capture various relationship nexuses in different quantiles of growth. The common 15th, 25th, 50th, 75th and 95th quantiles have been selected. The official Sustainable Development Goals (SDG) Index is applied to proxy the holistic conceptualization and policy achievement of the United Nation’s SDGs. The findings show a negative relationship between sustainable development and economic growth, indicating that achieving sustainable development goals will harm the economic growth. Increasing negative coefficient values from lower to higher quantiles imply increasing opportunity cost of degrowth towards increasing sustainable development. Besides, institutional quality did not affect economic growth, either directly or indirectly. The study suggests the necessity to review the existing policies, institutional structures, and strategies to foster compatibility between sustainable development, institutional quality, and growth.
Ações para o processo de internacionalização dos programas de pós-graduação do centro tecnológico da Universidade Federal de Santa Catarina
Authors: Stallivieri Luciane , Snoeijer Enio , Antonio de Melo Pedro
Published: September 2023

A internacionalização dos Programas de Pós-graduação nas Instituições de Ensino Superior brasileiras tem merecido grande destaque. Em decorrência da ampliação dos critérios de avaliação da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior a internacionalização tornou-se um dos fatores de indicação da qualidade dos Programas de Pós-graduação. Em 2017, o governo brasileiro lançou um Programa de Internacionalização (CAPES PrInt) para auxiliar as Instituições de Ensino Superior brasileiras no desenvolvimento de pesquisas, bolsas de estudos e no estabelecimento de parcerias institucionais com Instituições de Ensino Superior estrangeiras. Uma das Instituições de Ensino Superior contempladas foi a Universidade Federal de Santa Catarina selecionada para esta pesquisa. Trata-se de um estudo de caso que investigou as ações estratégicas de internacionalização dos Programas de Pós-graduação do Centro Tecnológico da Universidade Federal de Santa Catarina, que obtiveram os melhores resultados (notas 6 ou 7) na última avaliação quadrienal da CAPES. Por meio da ferramenta Google Forms, questionários foram aplicados aos coordenadores de 4 Programas, além da investigação documental. Concluiu-se que as estratégias adotadas pelos Programas se concentram na mobilidade acadêmica, nas missões de trabalho no exterior e nas publicações de trabalhos científicos em revistas internacionais. Em contrapartida, há pouco investimento na capacitação de docentes e na oferta de disciplinas em línguas estrangeiras, situação limitante para os avanços do processo de uma internacionalização abrangente.
β-cyclodextrin Mediated Green Synthesis of Bioactive Heterocycles
Authors: Tayade Yogesh Ashok , Wagh Yogesh Baburav , Dalal Dipak Sharadrao
Published: September 2023

In this review, we report β-cyclodextrin catalyzed green transformations of biologically
active heterocycles. β-Cyclodextrin is a seminatural product, water-soluble, highly efficient, and biodegradable
catalyst. β-Cyclodextrin is a versatile catalyst and promotes a variety of multicomponent
transformations, biomimetic reactions, C-C bond formation, and synthesis of some biologically
active natural products. It has been applicable to attain some name reactions, deprotection
of THP/MOM/Ac/Ts ethers, oxidative cleavage of epoxides, oxidative dehydrogenation of alcohol,
regioselective cyclization of chalcone epoxides and 2’-aminochalcones. The catalyst is useful to carry
out diastereoselective reactions, and it also plays a very important role in phase transfer catalysts.
Efficacy of Herbal Medicine in Hand Osteoarthritis: A Narrative Review
Authors: Aghili Seyedeh Mehrnaz , Sahebari Maryam , Salari Masoumeh , Noorabadi Parisa
Published: September 2023

Objective:

Osteoarthritis (OA) is one of the most prevalent joint disorders in the world
that has placed an enormous economic and social burden on governments and healthcare sectors in
many countries. Hand OA (HOA) is the most common peripheral arthritis, which is less investigated
than knee and hip OA. Due to limited approved drug choices and adverse effects of long-term
use of current regimens, we aimed to review the existing evidence that were used as oral herbal
medicine to treat HOA.

Methods:

The PubMed database was searched for both observational and interventional studies
that have investigated herbal medicine safety and efficacy in HOA, written in English and published
between 2010 and 2022.

Results:

A total of 5 original articles fulfilled the inclusion criteria, and each article assessed a different
herbal regimen. Overall, it seems desirable to add specific herbal treatments to the regimen
of HOA patients, specifically in case of early stages of HOA.

Conclusion:

Currently, the need for a low-risk alternative treatment in HOA patients is felt more
than ever. There are reliable references relating to the safety of Korean red ginseng, GCSB-5, XLGB,
and GS-GCu in these patients, although their efficacy was limited. Additionally, herbs like curcumin
and Boswellia serrata have positively affected patients with knee osteoarthritis. However,
there is a lack of strong evidence supporting their effectiveness in hand osteoarthritis (HOA). This
emphasizes the potential benefits that these herbs may have for HOA patients.
Comparison of Imaging Characteristics of Gangliogliomas between
Child/Adolescent Group and Adult Group
Authors: Zheng Xuan , Huang Quan , Guo Shao-Lei , Zou Meng-Sha , Zhu Hui , Li Shi-Ting
Published: September 2023

Background:

Ganglioglioma is a rare, slowly proliferating mixed glioneuronal tumor, with the highest incidence observed in children and young adults, but it
can also occur in adults.

Objective:

This study aimed to compare the imaging characteristics of ganglioglioma in children/adolescents and adults to facilitate radiographic diagnosis.

Methods:

In this retrospective study, a total of 32 patients were included and divided into two groups: the child/adolescent group (age < 18 years, n=19) and
the adult group (age ≥ 18 years, n=13). Various variables were analyzed, including maximum diameter, location, periphery, border, calcification,
unenhanced CT attenuation, T1WI, T2WI/FLAIR, and DWI signal intensity, enhancement pattern, degree of enhancement, homogeneity of
enhancement, solid/cystic component, peri-tumoral edema, intra-tumoral septa, peri-tumoral capsule, and intra-tumoral hemorrhage.

Results:

Most gangliogliomas were situated in the peripheral regions, particularly in the temporal lobe. The majority exhibited hypointense/isointense
signals on T1WI and hyperintense signals on T2WI/FLAIR and DWI, with predominantly heterogeneous nodular enhancement. Peri-tumoral
edema was significantly less frequent in the child/adolescent group, while marked enhancement was significantly more common in the adult group.
There was no significant difference in maximum diameter between the child/adolescent group and the adult group.

Conclusion:

Peri-tumoral edema was significantly less prevalent in the child/adolescent group, whereas marked enhancement was significantly more frequent in
the adult group. To ensure accurate results, a larger case series should be conducted to validate our findings.
Assessment of Apparent Diffusion Coefficient Parameters and Coefficient of
Variance in Discrimination of Receptor Status and Molecular Subtypes of
Breast Cancer
Authors: Ozkul Ozlem , Sever Ibrahim , Ozkul Bahattin
Published: September 2023

Objective:

The objective of this study was to investigate the diagnostic power of apparent diffusion coefficient/coefficient of variance (ADCcV) as well as ADC parameters formed based on magnetic resonance images (MRI) in the distinction of molecular breast cancer subtypes.

Methods:

The study involved 205 patients who had breast cancer at stages 1-3. Estrogen receptor (EsR), progesterone receptor (PrR), human epidermal growth factor receptor 2 (Her2), and proliferation index (Ki-67) were histologically analyzed in the tumor. The correlations between the immunohistochemistry and intrinsic subtypes were analyzed using ADC and ADCcV.

Results:

The maximum whole tumor (WTu) ADC (p=0.004), minimum WTu ADC (p<0.001), and mean WTu ADC (p<0.001) values were significantly smaller in the EsR-positive tumors than those in the EsR-negative tumors. Compared to the PrR-negative tumors, the PrR-positive tumors showed significantly smaller maximum, minimum, and mean WTu ADC values (p=0.005, p=0.001, and p<0.001, respectively). In the comparisons of the molecular subtypes in terms of ADCcV, the p-values indicated statistically significant differences between the luminal A (lumA) group and the triple negative (TN) group, between the luminal B (lumB) group and the TN group, and between the Her2-enriched and TN groups (p<0.001, p=0.011, and p=0.004, respectively). Considering the luminal and non-luminal groups, while a significant difference was observed between the groups considering their minimum, maximum, and mean WTu ADC values, their ADCcV values were similar (p<0.001, p=0.004, and p<0.001, respectively).

Conclusion:

Using ADCcV in addition to ADC parameters increased the diagnostic power of diffusion weighted-MRI (DW-MRI) in the distinction of molecular subtypes of breast cancer.
A Systematic Review and Meta-Analysis of the Metal Nano-Particles Loaded with Herbal Drugs Moieties Against Breast Cancer
Authors: Nishal Suchitra , Kumar Virender , Phaugat Parmita , Kumar Davinder , Khatri Naveen , Singh Gajendra
Published: September 2023

Background:

Breast cancer is the most prevalent cancer among women. About 685K deaths
were globally listed in 2020 by the World Health Organization. Nowadays, scientists prefer to use herbal
medicines due to their low toxicity. Herbal medicines are used to overcome the toxicity effects of
surgical removal, radio-chemo therapy and medication, which have a lot of risk of damaging the healthy
tissues. To overcome this, enhance bioavailability and target specify, nano-formulation chemotherapy
was introduced using herbal moiety for anticancer activity. The use of metallic nanoparticles (MNPs),
particularly those made of silver, cobalt, zinc, and gold as contrast, antibacterial, anticancer, and drug
delivery agents has revolutionised the medicinal field. Although MNPs can be made via exacting physical
and chemical processes, a biological method utilising natural materials has been established recently.

Objectives:

This review article will offer a succinct explanation of the use of MNPs and its potential
impact on herbal medicines in the future.

Methods:

Using PRISMA principles, this review systematically examines studies that concentrate on metal nanoparticles loaded with herbal compounds for the treatment of breast cancer. Various Databases were studied: PubMed, Elsevier, ScienceDirect, SpringerLink, Taylor & Francis Online, ACS Publications, Publishing Royal Society of Chemistry, and Future Medicines. Studies were selected if they were peer-reviewed primary studies published in the past 10 years.

Results:

We found that many herbal nano-formulations are more effective in breast cancer treatment than other types of formulations. Efficacy, safety and drug stability are also enhanced using nano-formulations.

Conclusion:

Nano-formulation is found to be more effective in the treatment of breast cancer.
Patient Perceptions with Virtual Family Medicine Clinics in the Eastern Province of Saudi Arabia
Authors: Alsubaie Hajer Adel , Bugis Bussma Ahmed
Published: September 2023

Background:

With the growth of technology and with many people having access to the internet, there has been an increasing trend of many people embracing telemedicine and virtual clinics. In Saudi Arabia, there is limited data and information about the perceptions of the patients regarding virtual clinics, especially for family medicine virtual care.

Objective:

This study was conducted to fill this gap by determining the patients’ perceptions of family medicine virtual clinics in Saudi Arabia.

Methods:

The study was a cross-sectional descriptive study. This study employed the use of a survey approach to evaluate the patient's perceptions of family medicine virtual care in the Eastern Province of Saudi Arabia. The targeted population was the adult patients who used family medicine virtual services in 2021.

Results:

The study population was 395 participants. The plurality of respondents (38.50%) had rated their previous use of virtual family medicine as very good, and 44.60% have experienced an improvement in their health, 46.60% received enough information, and 49.10% felt that their privacy was respected.

Conclusion:

In Saudi Arabia, virtual clinics seem to be increasing in terms of popularity, and different approaches have been used in different conditions and specialties. Virtual family medicine services need improvement for enhanced adoption. Home health management, protecting patient privacy, and improvements in technical requirements would enhance patient experience with virtual family medicine services for many patients in the Eastern Province of Saudi Arabia.
Exploring potentials of Electuaries for Controlling Chronic Respiratory
Diseases in Unani Medicine: A Systematic Review
Authors: Khan Muzayyana , Akhlaq Shaheen , Shamsi Shariq
Published: September 2023

Background:

Chronic respiratory diseases rate has been increasing alarmingly, causing huge burden on the mortality and morbidity. Environmental pollution and occupational exposure, the major identified risk factors and endless adverse effects of conventional medicine put forward the need for better alternative options. Electuaries are the pharmaceutical formulation of poly herbal drugs that are employed as effective remedy for respiratory disorders in Unani system of medicine.

Objective:

The aim is to assess the effectiveness of Unani pharmaco-therapeutics in the management of various respiratory diseases and the computation of drug/water and drug/sugar ratio for the elaborated electuaries.

Methods:

A web-based review on certain selected Unani drugs and its molecular mechanism was carried out using the data bases such as Pub Med, Google Scholar, Science Direct and Scopus published until the end of June 2022.

Results:

It was observed that several single drugs such as Khayarshambar (Cassia fistula L.), Sapistan (Cordia dichotama Forst), Asl-us- Soos (Glycyrrhiza glabra L.), Khatmi (Althea officianialis L.), Za’fran (Crocus sativus L.), Behīdāna (Cydonia oblonga Mill.) etc. used in Unani formulations claimed to be effective in management of respiratory diseases like COVID 19. The herbs and its chemical constituents showed the preventive effect on respiratory diseases with inflammatory cell mediators, lung pathologies, airway response and immunomodulatory effects. The results of research studies (preclinical, clinical or in silico) and their molecular mechanisms on Electuaries have proved to be optimal for the respiratory system.

Conclusion:

Unani poly-pharmaceutics showed anti-inflammatory, anti-viral, anti-bacterial, anti-allergic, anti- tussive, mucolytic actions arresting respiratory diseases.
Capnometry in the intensive care unit (literature review)
Authors: Krishtafor D.A. , Kravets O.V. , Klygunenko O.M. , Yekhalov V.V. , Stanin D.M.
Published: September 2023

Capnometry/capnography is a method of measuring and displaying the concentration of carbon dioxide (CO2) in respiratory gases. Most often, this term involves measuring the partial pressure of carbon dioxide (PCO2) at the end of exhalation (end-tidal CO2, ETCO2). The curve formed during capnography is called a capnogram, where the inspiratory and expiratory segments are distinguished. The main determinants of ETCO2 are CO2 production, cardiac output, pulmonary perfusion, and alveolar ventilation. Normally, ETCO2 is 2–5 mm Hg lower than arterial blood PCO2. This gradient increases when the ventilation-perfusion ratio is impaired, for example, in pulmonary embolism or pulmonary hypoperfusion during cardiac arrest. The shape of the capnogram, in turn, depends on the concentration of CO2 in the alveoli and the pattern of their emptying, as well as on cardiac output. This allows the use of capnography to register bronchospasm, CO2 circulation in the circuit, spontaneous breathing attempts, etc. In Ukraine, capnometry and capnography are routinely used in the anesthesia during laparoscopic surgeries, which require strict control of ETCO2 due to the insufflation of CO2 into the abdominal cavity and its absorption by the peritoneum. However, the spectrum of capnometry application is actually much wider than just laparoscopic surgery. In the intensive care unit, it includes but is not limited to the following indications: confirmation of the endotracheal tube position during tracheal intubation; monitoring the respiratory circuit integrity, including while turning and transporting a patient; evaluation of the cardiopulmonary resuscitation effectiveness; evaluation of the mask ventilation effectiveness; breathing monitoring during procedural sedation; monitoring during mechanical ventilation; auxiliary monitoring of hemodynamics. This literature review discusses the advantages, disadvantages and methods of using capnometry/capnography for each of the listed indications in detail.
Comparison of the efficiency of the remote approaches for analgesia after total hip arthroplasty
Authors: Gavrykov O.Y. , Kupin V.I. , Kolomachenko V.I.
Published: September 2023

Background. Recently, two blocks have been proposed: one of which is the most proximal and is called the erector spinae plane (ESP) block, the other is the most distal and is called pericapsular nerve group (PENG) block. Both techniques are performed under ultrasound control, are positioned as effective and safe, without muscle weakness. The purpose of the work: to evaluate the clinical effectiveness of the most remote approaches (ESP and PENG) for anesthesia in terms of the adequacy of analgesia and physical activity of patients after hip arthroplasty. Materials and methods. The study included 70 ASA II–III patients: 40 women and 30 men with an average age of 64.6 ± 10.7 years who underwent planned primary total hip arthroplasty for disease or fracture under spinal anesthesia. After the surgery, ESP block was performed in group I (n = 35), PENG block in group II (n = 35), 30 ml of 0.25% bupivacaine solution was injected. The ability to cover a distance of 30 meters without time limits, the maximum severity of the pain syndrome, the need for opioids (nalbuphine), the duration of the block and the number of patients with postoperative complications were evaluated. Results. The duration of PENG block was on average 8.6 (5.6–9.8) hours, which statistically significantly exceeded this indicator in patients who received ESP block with an average duration of 5 (3.8–6.0) hours (p < 0.001). With comparable analgesia in both groups, patients who received PENG block required less time to walk the 30-meter distance — 31.0 (27.0–47.0) hours compared to those who received ESP block — 45.0 (32.0–54.0) hours (p = 0.006). In group II, 28.6 % of patients did not need opioids in the postoperative period, and this indicator in group I was only 8.5 % (p = 0.036), demonstrating the better analgesic potential of PENG block. Conclusions. Given the ease of implementation and safety of both regional methods, as well as the effectiveness of PENG block, it appears to be a real alternative to other regional methods in this category of patients.
Increasing Knowledge In The Health Protocol Of Covid-19 Prevention With Health Education In Boarding Schools
Authors: Fradianto Ikbal , Priyono Djoko , Yulanda Nita Arisanti , Andriyanto Arief
Published: September 2023

The COVID-19 pandemic that has occurred in the world has also impacted the world of education. The school's policy initially closed face-to-face activities, but over time allowed schools to return to holding face-to-face school activities on the condition that they have to implement health protocol. Implementing the health protocol is essential for all students to do in schools to prevent the transmission of COVID-19 in the school environment. The implementation of the health protocol starts from the knowledge that students must have; therefore, there need to be additional efforts to improve students' knowledge. Actions that can be made in students' knowledge suitable are by providing health education. This study aims to provide education about implementing the Covid-19 prevention health protocol on changes in knowledge. The methodology used in this study was quasi-experimental without using a control group, the statistical test used was paired t-test. The results of this study indicate a change in knowledge between before being given education and after that with a P-value <0.005. There is an effect of providing education on changes in knowledge between before and after being given education-related to implementing the Covid-19 prevention health protocol.
The Most Essential Skills for Newly Qualified Teachers
Authors: Zhao Xueqing
Published: September 2023

The primary purpose of this essay is to propose the most essential skills for being a new teacher. Hence, three main sections are included in this essay. The first skill this essay would like to discuss is management skill. This section will argue two primary skills: personal and classroom management. Firstly, practical individual management skills could reduce the anxiety of entrants. Newly qualified teachers should design a work plan to prevent overpressure. Reasonable use of time is likely to enhance the satisfaction of their work. Therefore, that might reduce the school’s resignation rate, and the other management skills will emphasise students’ behaviours. Several students would like to know the last defensive line of their new teachers. Consequently, they might keep challenging the tolerance of their teachers. This is the reason why classroom management skills should be paid attention. Teachers should maintain each student’s rights so that they can have a harmonious climate in the classroom. Hence, beginning teachers should lead class management—the second section associates with the relationship between teachers and other people, including students, staff and parents. When communicating with students, teachers could apply particular methods to shorten the distance between pupils, such as appropriate humour. Furthermore, the other skilful colleagues might be regarded as beginning teachers’ teachers because of their extensive experiences. On the other hand, a harmonious relationship with parents is likely to promote children’s progress. Apart from these two skills, the third one that will be argued is the teacher’s individual teaching and development skills. Accordingly, the effective delivery of knowledge skills might decide whether or not the class is booming. Positive teaching skills should stimulate students’ critical thinking to achieve academic achievements. Moreover, beginning teachers should keep the belief that they are required to continue with professional development.