bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation
Authors: Barani Ali , Beikverdi Kamyar , Mashhadi Benyamin , Parsapour Naeimeh , Rezaei Mohammad , Javid Pegah , Azadeh Mansoureh
Published: December 2023

Background. Gastric cancer (GC) is the second most frequent cause of cancer-related death worldwide and the fourth most common malignancy. Despite significant improvements in patient survival over the past few decades, the prognosis for patients with GC remains dismal because of the high recurrence rate. In this comprehensive system biology and experimental investigation, we aimed to find new novel diagnostic biomarkers of GC through a regulatory RNA interaction network. Methods. Gene expression, coexpression, and survival analyses were performed using microarray and RNAseq datasets (analyzed by RStudio, GEPIA2, and ENCORI). RNA interaction analysis was performed using miRWalk and ENCORI online databases. Gene set enrichment analysis (GSEA) was performed to find related signaling pathways of up- and downregulated genes in the microarray dataset. Gene ontology and pathway enrichment analysis were performed by the enrichr database. Protein interaction analysis was performed by STRING online database. Validation of expression and coexpression analyses was performed using a qRT-PCR experiment. Results. Based on bioinformatics analyses, THBS2 (FC: 7.14, FDR<0.0001) has a significantly high expression in GC samples. lncRNAs BAIAP2-AS1, TSIX, and LINC01215 have RNA interaction with THBS2. BAIAP2-AS1 (FC: 1.44, FDR: 0.018), TSIX (FC: 1.34, FDR: 0.038), and LINC01215 (FC: 1.19, FDR: 0.046) have significant upregulation in GC samples. THBS2 has a significant role in the regulation of the ECM-receptor signaling pathway. miR-4677-5p has a significant RNA interaction with THBS2. The expression level of THBS2, BAIAP2-AS1, TSIX, and LINC01215 has a nonsignificant negative correlation with the survival rate of GC patients (HR: 0.28, logrank p: 0.28). qRT-PCR experiment validates mentioned bioinformatics expression analyses. BAIAP2-AS1 (AUC: 0.7136, p value: 0.0096), TSIX (AUC: 0.7456, p value: 0.0029), and LINC01215 (AUC: 0.7872, p value: 0.0005) could be acceptable diagnostic biomarkers of GC. Conclusion. BAIAP2-AS1, lncRNA LINC01215, lncRNA TSIX, and miR-4677-5p might modulate the ECM-receptor signaling pathway via regulation of THBS2 expression level, as the high-expressed noncoding RNAs in GC. Furthermore, mentioned lncRNAs could be considered potential diagnostic biomarkers of GC.
Implicit Finite Difference Simulation of Hybrid Nanofluid along a Vertical Thin Cylinder with Sinusoidal Wall Heat Flux under the Effects of Magnetic Field
Authors: Khan Mashiyat , Hossain Amzad , Parvin Afroja , Molla Md. Mamun
Published: December 2023

A numerical analysis of magnetohydrodynamic natural convection along a thin vertical cylinder with a sinusoidal heat flux at the wall immersed in copper (Cu) and aluminum-oxide (Al2O3) hybrid nanofluids has been studied. A 2D vertical thin cylinder shape geometry has been considered with a radius of R. The fluid flow is considered laminar and incompressible with the Prandtl number of Pr = 6.2 and 10% concentration of hybrid nanoparticles. The nondimensional governing equations have been solved numerically by using the implicit finite difference method. An in-house FORTRAN 90 code is used for solving this problem and the code is validated with the available benchmark results. Numerical simulations have been performed for a wide range of governing parameters, Hartmann number from Ha = 0 to Ha = 4, nanoparticles volume fractions ϕ = 0.0 to ϕ = 0.1, and the amplitude of the wall heat flux ε = 0.0–0.3. The findings have been illustrated in terms of streamlines, isotherms, local skin friction coefficients, local Nusselt numbers, velocity, and temperature distributions. The flow field and temperature distribution within the boundary layer are deceased by the effects of the wall heat flux amplitudes. It is also noted that the rate of heat transfer increases with particle volume fraction and the amplitude of the wall heat flux. According to the findings, Nu increases by 24.72% as ϕ increases from 0 to 0.1 while ε = 0.3, and 27.66% while ε increases from 0.0 to 0.3 at 5% hybrid nanoparticles. The local skin frictions and Nusselt number diminish with the increment of the Hartman number due to the effects of the Lorenz force. The findings of this study can lead to a better understanding of the fundamental principles regarding the behavior of hybrid nanofluids under complex conditions, such as a vertical thin cylinder with a sinusoidal wall heat flux. Understanding the behavior of hybrid nanofluids in the presence of a magnetic field and a nonuniform wall heat flow can also lead to the development of innovative heat transfer enhancement strategies.
Figure S8 from Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma
Authors: Kim Ye-Jin , Tsang Tiffany , Anderson Grace R. , Posimo Jessica M. , Brady Donita C.
Published: December 2023

Supplemental Figure S8. BRAFV600E-mutant melanoma cells engineered to be resistant to MAPK inhibitors maintain sensitivity to the combination of TTM and BH3 mimetics.
Figure S7 from Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma
Authors: Kim Ye-Jin , Tsang Tiffany , Anderson Grace R. , Posimo Jessica M. , Brady Donita C.
Published: December 2023

Supplemental Figure S7. TTM reduces BCL2 protein expression and lowers the apoptotic threshold when combined with BH3 mimetics in MAPK inhibitor resistant BRAFV600E-positive melanoma.
Figure S6 from Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma
Authors: Kim Ye-Jin , Tsang Tiffany , Anderson Grace R. , Posimo Jessica M. , Brady Donita C.
Published: December 2023

Supplemental Figure S6. TTM sensitizes vemurafenib-resistant BRAFV600E-positive melanoma cells to a BCL2 protein inhibitor.
Figure S4 from Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma
Authors: Kim Ye-Jin , Tsang Tiffany , Anderson Grace R. , Posimo Jessica M. , Brady Donita C.
Published: December 2023

Supplemental Figure S4. Targeting select BCL2 family proteins increases sensitivity to TTM in BRAFV600E-positive melanoma.
Figure S3 from Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma
Authors: Kim Ye-Jin , Tsang Tiffany , Anderson Grace R. , Posimo Jessica M. , Brady Donita C.
Published: December 2023

Supplemental Figure S3. Normalized percent inhibition of bioactive compound library alone or in combination with IC20 of TTM in BRAFV600E-positive melanoma cells.
Supplementary Tables 1 and 2 from PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis
Authors: Samanta Debangshu , Park Youngrok , Andrabi Shaida A. , Shelton Laura M. , Gilkes Daniele M. , Semenza Gregg L.
Published: December 2023

Supplementary Table S1. Oligonucleotide sequences of shRNAs targeting PHGDH. Table S2. Oligonucleotide sequence of RT-qPCR primers.
Supplementary Figure Legends from RETRACTED: PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis
Authors: Samanta Debangshu , Park Youngrok , Andrabi Shaida A. , Shelton Laura M. , Gilkes Daniele M. , Semenza Gregg L.
Published: December 2023

Legends for Supplementary Figures S1-S6
Figure S6 from The EZH2–PHACTR2–AS1–Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer
Authors: Chu Wenhui , Zhang Xi , Qi Lihua , Fu Yenan , Wang Peng , Zhao Wei , Du Juan , Zhang Jing , Zhan Jun , Wang Yunling , Zhu Wei-Guo , Yu Yu , Zhang Hongquan
Published: December 2023

Figure S6 shows PHACTR2-AS1-30nt-RNA inhibits cancer cell growth and metastasis in vivo.
Supplementary Legends from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
Authors: Mueller Adam C. , Piper Miles , Goodspeed Andrew , Bhuvane Shiv , Williams Jason S. , Bhatia Shilpa , Phan Andy V. , Van Court Benjamin , Zolman Kathryn L. , Peña Brisa , Oweida Ayman J. , Zakem Sara , Meguid Cheryl , Knitz Michael W. , Darragh Laurel , Bickett Thomas E. , Gadwa Jacob , Mestroni Luisa , Taylor Matthew R.G. , Jordan Kimberly R. , Dempsey Peter , Lucia M. Scott , McCarter Martin D. , Chiaro Marco Del , Messersmith Wells A. , Schulick Richard D. , Goodman Karyn A. , Gough Michael J. , Greene Casey S. , Costello James C. , Neto Antonio Galveo , Lagares David , Hansen Kirk C. , Van Bokhoven Adrie , Karam Sana D.
Published: December 2023

Supplementary Legends
Figure S6 from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
Authors: Mueller Adam C. , Piper Miles , Goodspeed Andrew , Bhuvane Shiv , Williams Jason S. , Bhatia Shilpa , Phan Andy V. , Van Court Benjamin , Zolman Kathryn L. , Peña Brisa , Oweida Ayman J. , Zakem Sara , Meguid Cheryl , Knitz Michael W. , Darragh Laurel , Bickett Thomas E. , Gadwa Jacob , Mestroni Luisa , Taylor Matthew R.G. , Jordan Kimberly R. , Dempsey Peter , Lucia M. Scott , McCarter Martin D. , Chiaro Marco Del , Messersmith Wells A. , Schulick Richard D. , Goodman Karyn A. , Gough Michael J. , Greene Casey S. , Costello James C. , Neto Antonio Galveo , Lagares David , Hansen Kirk C. , Van Bokhoven Adrie , Karam Sana D.
Published: December 2023

Supplementary figure
Figure S4 from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
Authors: Mueller Adam C. , Piper Miles , Goodspeed Andrew , Bhuvane Shiv , Williams Jason S. , Bhatia Shilpa , Phan Andy V. , Van Court Benjamin , Zolman Kathryn L. , Peña Brisa , Oweida Ayman J. , Zakem Sara , Meguid Cheryl , Knitz Michael W. , Darragh Laurel , Bickett Thomas E. , Gadwa Jacob , Mestroni Luisa , Taylor Matthew R.G. , Jordan Kimberly R. , Dempsey Peter , Lucia M. Scott , McCarter Martin D. , Chiaro Marco Del , Messersmith Wells A. , Schulick Richard D. , Goodman Karyn A. , Gough Michael J. , Greene Casey S. , Costello James C. , Neto Antonio Galveo , Lagares David , Hansen Kirk C. , Van Bokhoven Adrie , Karam Sana D.
Published: December 2023

Supplementary figure
Figure S3 from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
Authors: Mueller Adam C. , Piper Miles , Goodspeed Andrew , Bhuvane Shiv , Williams Jason S. , Bhatia Shilpa , Phan Andy V. , Van Court Benjamin , Zolman Kathryn L. , Peña Brisa , Oweida Ayman J. , Zakem Sara , Meguid Cheryl , Knitz Michael W. , Darragh Laurel , Bickett Thomas E. , Gadwa Jacob , Mestroni Luisa , Taylor Matthew R.G. , Jordan Kimberly R. , Dempsey Peter , Lucia M. Scott , McCarter Martin D. , Chiaro Marco Del , Messersmith Wells A. , Schulick Richard D. , Goodman Karyn A. , Gough Michael J. , Greene Casey S. , Costello James C. , Neto Antonio Galveo , Lagares David , Hansen Kirk C. , Van Bokhoven Adrie , Karam Sana D.
Published: December 2023

Supplementary figure
Figure S1 from Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer
Authors: Mueller Adam C. , Piper Miles , Goodspeed Andrew , Bhuvane Shiv , Williams Jason S. , Bhatia Shilpa , Phan Andy V. , Van Court Benjamin , Zolman Kathryn L. , Peña Brisa , Oweida Ayman J. , Zakem Sara , Meguid Cheryl , Knitz Michael W. , Darragh Laurel , Bickett Thomas E. , Gadwa Jacob , Mestroni Luisa , Taylor Matthew R.G. , Jordan Kimberly R. , Dempsey Peter , Lucia M. Scott , McCarter Martin D. , Chiaro Marco Del , Messersmith Wells A. , Schulick Richard D. , Goodman Karyn A. , Gough Michael J. , Greene Casey S. , Costello James C. , Neto Antonio Galveo , Lagares David , Hansen Kirk C. , Van Bokhoven Adrie , Karam Sana D.
Published: December 2023

Supplementary figure
Data from Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
Authors: Stalnecker Clint A. , Grover Kajal R. , Edwards A. Cole , Coleman Michael F. , Yang Runying , DeLiberty Jonathan M. , Papke Björn , Goodwin Craig M. , Pierobon Mariaelena , Petricoin Emanuel F. , Gautam Prson , Wennerberg Krister , Cox Adrienne D. , Der Channing J. , Hursting Stephen D. , Bryant Kirsten L.
Published: December 2023

Abstract
The aggressive nature of pancreatic ductal adenocarcinoma (PDAC) mandates the development of improved therapies. As KRAS mutations are found in 95% of PDAC and are critical for tumor maintenance, one promising strategy involves exploiting KRAS-dependent metabolic perturbations. The macrometabolic process of autophagy is upregulated in KRAS-mutant PDAC, and PDAC growth is reliant on autophagy. However, inhibition of autophagy as monotherapy using the lysosomal inhibitor hydroxychloroquine (HCQ) has shown limited clinical efficacy. To identify strategies that can improve PDAC sensitivity to HCQ, we applied a CRISPR-Cas9 loss-of-function screen and found that a top sensitizer was the receptor tyrosine kinase (RTK) insulin-like growth factor 1 receptor (IGF1R). Additionally, reverse phase protein array pathway activation mapping profiled the signaling pathways altered by chloroquine (CQ) treatment. Activating phosphorylation of RTKs, including IGF1R, was a common compensatory increase in response to CQ. Inhibition of IGF1R increased autophagic flux and sensitivity to CQ-mediated growth suppression both in vitro and in vivo. Cotargeting both IGF1R and pathways that antagonize autophagy, such as ERK–MAPK axis, was strongly synergistic. IGF1R and ERK inhibition converged on suppression of glycolysis, leading to enhanced dependence on autophagy. Accordingly, concurrent inhibition of IGF1R, ERK, and autophagy induced cytotoxicity in PDAC cell lines and decreased viability in human PDAC organoids. In conclusion, targeting IGF1R together with ERK enhances the effectiveness of autophagy inhibitors in PDAC.
Significance:
Compensatory upregulation of IGF1R and ERK–MAPK signaling limits the efficacy of autophagy inhibitors chloroquine and hydroxychloroquine, and their concurrent inhibition synergistically increases autophagy dependence and chloroquine sensitivity in pancreatic ductal adenocarcinoma.
Data from Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma
Authors: Kim Ye-Jin , Tsang Tiffany , Anderson Grace R. , Posimo Jessica M. , Brady Donita C.
Published: December 2023

Abstract
The principal unmet need in BRAFV600E-positive melanoma is lack of an adequate therapeutic strategy capable of overcoming resistance to clinically approved targeted therapies against oncogenic BRAF and/or the downstream MEK1/2 kinases. We previously discovered that copper (Cu) is required for MEK1 and MEK2 activity through a direct Cu–MEK1/2 interaction. Repurposing the clinical Cu chelator tetrathiomolybdate (TTM) is supported by efficacy in BRAFV600E-driven melanoma models, due in part to inhibition of MEK1/2 kinase activity. However, the antineoplastic activity of Cu chelators is cytostatic. Here, we performed high-throughput small-molecule screens to identify bioactive compounds that synergize with TTM in BRAFV600E-driven melanoma cells. Genetic perturbation or pharmacologic inhibition of specific members of the BCL2 family of antiapoptotic proteins (BCL-W, BCL-XL, and MCL1) selectively reduced cell viability when combined with a Cu chelator and induced CASPASE-dependent cell death. Further, in BRAFV600E-positive melanoma cells evolved to be resistant to BRAF and/or MEK1/2 inhibitors, combined treatment with TTM and the clinically evaluated BCL2 inhibitor, ABT-263, restored tumor growth suppression and induced apoptosis. These findings further support Cu chelation as a therapeutic strategy to target oncogene-dependent tumor cell growth and survival by enhancing Cu chelator efficacy with chemical inducers of apoptosis, especially in the context of refractory or relapsed BRAFV600E-driven melanoma.
Significance:
This study unveils a novel collateral drug sensitivity elicited by combining copper chelators and BH3 mimetics for treatment of BRAFV600E mutation-positive melanoma.
Data from Genetic Dissociation of Glycolysis and the TCA Cycle Affects Neither Normal nor Neoplastic Proliferation
Authors: Jackson Laura E. , Kulkarni Sucheta , Wang Huabo , Lu Jie , Dolezal James M. , Bharathi Sivakama S. , Ranganathan Sarangarajan , Patel Mulchand S. , Deshpande Rahul , Alencastro Frances , Wendell Stacy G. , Goetzman Eric S. , Duncan Andrew W. , Prochownik Edward V.
Published: December 2023

Abstract
Rapidly proliferating cells increase glycolysis at the expense of oxidative phosphorylation (oxphos) to generate sufficient levels of glycolytic intermediates for use as anabolic substrates. The pyruvate dehydrogenase complex (PDC) is a critical mitochondrial enzyme that catalyzes pyruvate's conversion to acetyl coenzyme A (AcCoA), thereby connecting these two pathways in response to complex energetic, enzymatic, and metabolic cues. Here we utilized a mouse model of hepatocyte-specific PDC inactivation to determine the need for this metabolic link during normal hepatocyte regeneration and malignant transformation. In PDC “knockout” (KO) animals, the long-term regenerative potential of hepatocytes was unimpaired, and growth of aggressive experimental hepatoblastomas was only modestly slowed in the face of 80%–90% reductions in AcCoA and significant alterations in the levels of key tricarboxylic acid (TCA) cycle intermediates and amino acids. Overall, oxphos activity in KO livers and hepatoblastoma was comparable with that of control counterparts, with evidence that metabolic substrate abnormalities were compensated for by increased mitochondrial mass. These findings demonstrate that the biochemical link between glycolysis and the TCA cycle can be completely severed without affecting normal or neoplastic proliferation, even under the most demanding circumstances. Cancer Res; 77(21); 5795–807. ©2017 AACR.
People with Multiple Long-Term Health Problems: Personalized Care Planning
Authors: Canais Edgar , Nunes Lucília
Published: December 2023

Background: The personalized care planning is a collaborative process used in managing long-term health conditions when the person and health professionals identify and discuss problems caused by or related to the health condition and develop a plan to address them. Objective: The aim of the study was to map the evidence on the impact of personalized care planning management on health outcomes in persons with multiple long-term health problems in the community. Methods: Scoping review was based on the Joanna Briggs Institute protocol; the search strategy was carried out in platforms and databases online; the participants are adults, with chronic disease or long-term health conditions, in the period from 2016 to 2021, in English, Spanish, and Portuguese; the exclusion criteria included studies of adults with dementia and intellectual disability; 22 studies were obtained. We applied critical appraisal, and two independent reviewers performed data extraction; data synthesis was performed in narrative form. Results: Nursing interventions, the strategies used by nurses, and the production of health gains (maintaining the level of health and well-being) promoted by nurses through the proper management of personalized care planning were identified. Conclusions: Nurses develop a wide range of interventions, using various strategies that promote health gains through the proper management of personalized care planning. Contributions to the Practice: Personalized care planning focuses on people with multimorbidity, and the health gains reduce, also, the nurses’ workload.
Clinical Significance of the Preoperative Inflammatory Burden Index in Esophageal Cancer
Authors: Yin Chengzeng , Okugawa Yoshinaga , Kitajima Takahito , Shimura Tadanobu , Ma Ruiya , Kawamura Mikio , Yoshiyama Shigeyuki , Okita Yoshiki , Ohi Masaki , Toiyama Yuji
Published: December 2023

Introduction: The inflammatory burden index (IBI) serves as a prognostic marker for several cancers. Here, we evaluated the predictive value of preoperative IBI associated with the surgical and oncological outcomes of patients with esophageal cancer (EC). Methods: The IBI was formulated as C-reactive protein × neutrophil/lymphocyte. We retrospectively analyzed preoperative IBI of 147 EC patients receiving esophagectomy between 2008 and 2018. Cox proportional hazards models and multivariable logistic regression were employed to identify independent risk factors of surgical site infection and prognosis. Results: Increased preoperative IBI significantly correlated with higher tumor stage. Patients with high IBI experienced shorter overall survival (p = 0.0002) and disease-free survival (p = 0.002) compared with those with low IBI. In the adjusted Cox proportional hazards regression models, increased IBI served as an independent prognostic factor for overall survival (hazard ratio, 3.56; 95% confidence interval, 1.79–7.34; p = 0.0003) and disease-free survival (hazard ratio, 3.03; 95% confidence interval, 1.60–5.92; p = 0.007). Multivariable analysis identified preoperative high IBI which served as an independent risk factor for overall surgical site infection (odds ratio, 2.53; 95% confidence interval, 1.00–6.38; p = 0.049). Conclusion: Preoperative IBI may serve as a useful predictor of prognosis and surgical site infection of patients with EC after esophagectomy.
Pyroptosis: The Determinator of Cell Death and Fate in Acute Kidney Injury
Authors: Xiong Jiachuan , Zhao Jinghong
Published: December 2023

Background: Acute kidney injury (AKI) is kidney damage that leads to a rapid decline in function. AKI primarily occurs when the tubular epithelium is damaged, causing swelling, loss of brush margin, and eventual apoptosis. Research has shown that tubular epithelial cell damage in AKI is linked to cell cycle arrest, autophagy, and regulation of cell death. Summary: Pyroptosis, a type of programmed cell death triggered by inflammation, is believed to play a role in the pathophysiology of AKI. Cumulative evidence has shown that pyroptosis is the main cause of tubular cell death in AKI. Thus, targeted intervention of pyroptosis may be a promising therapeutic approach for AKI. This review delves deep into the cutting-edge research surrounding pyroptosis in the context of AKI, shedding light on its intricate mechanisms and potential implications for clinical practice. Additionally, we explore the exciting realm of potential preclinical treatment options for AKI, aiming to pave the way for future therapeutic advancements. Key Messages: Pyroptosis, a highly regulated form of cell death, plays a crucial role in determining the fate of cells during the development of AKI. This intricate process involves the activation of inflammasomes, which are multi-protein complexes that initiate pyroptotic cell death. By understanding the mechanisms underlying pyroptosis, researchers aim to gain insights into the pathogenesis of AKI and potentially identify new therapeutic targets for this condition.
Gabriel Cohn. A difícil república
Authors: Santos Patrícia da Silva
Published: December 2023

Resenha do livro de Gabriel Cohn, A difícil república, Rio de Janeiro: Azougue, 2023.
Ativismo anti-imigração e extrema-direita na Europa: entrevista com Kristian Berg Harpviken
Authors: Zanetti Lucas Arantes , Silva Thaís  França da
Published: December 2023

Dr. Kristian Berg Harpviken é sociólogo e professor pesquisador no Peace Research Institute Oslo (PRIO). Ele foi o diretor do instituto de 2009 a 2017 e atualmente lidera o PRIO Middle East Centre. Os interesses de pesquisa de Harpviken incluem processos de paz, construção da paz, dinâmica da guerra civil, migração e comunidades transnacionais e metodologia em contextos difíceis. Harpviken foi pesquisador visitante na University of Chicago e na Georgetown University, e é associado da University of York, do Doha Institute for Graduate Studies e do Institute for National Security Studies Sri Lanka. Harpviken é conhecido por sua competência em questões relacionadas ao Afeganistão e arredores, mas também trabalhou em vários outros países, incluindo Angola, Bósnia-Herzegovina, Irã, Iraque, Líbano, Moçambique, Paquistão, África do Sul e Turquia. Harpviken é um comentarista de mídia frequentemente e faz palestras regularmente para o público acadêmico e geral. Ele é autor de Social Networks and Migration in Afghanistan (Palgrave Macmillan, 2009), and (with Shahrbanou Tadjbakhsh), A Rock Between Hard Places: Afghanistan as an Arena for Regional Insecurity (Hurst/Oxford University Press, 2016).
Plataformas digitais de cuidado no Brasil
Authors: Andrada Ana Carolina , Cardoso Ana Claudia Moreira , Guimarães Nadya Araújo , Moreno Renata , Pereira Maria Julia Tavares
Published: December 2023

As empresas-plataforma voltadas ao trabalho de cuidado expandiram-se velozmente nos últimos anos no Brasil, em especial após a recente crise sanitária. Tal expansão trouxe para a ordem do dia o tema deste artigo, a saber, os possíveis efeitos da pandemia de Covid-19 sobre a digitalização da intermediação do trabalho nos cuidados, um segmento para o qual a literatura brasileira sobre plataformização do trabalho tem estado pouco atenta. Para acompanhar o ritmo desse crescimento várias estratégias foram adotadas diante do desafio da falta de dados desagregados para o setor. Assim, mapeamos os aplicativos e plataformas de cuidado, construindo um banco a partir de dados da principal loja de apps no país; bem assim, analisamos os sites, os Termos de Serviços e Condições de Uso de três plataformas de cuidado direto e indireto. Conduzimos, ainda, entrevistas com trabalhadoras nessas plataformas e analisamos suas denúncias postadas no site Reclame Aqui. Concluímos que a governança das plataformas afetou o cotidiano das trabalhadoras sob diferentes formas e com efeitos variados conforme cada plataforma. Entre eles, destacamos o diálogo com os clientes, o controle via sistema de notas prescritivas e punitivas, a inclusão de tarefas que iam além da atividade contratada, bem como a sobreposição de diferentes formas de cuidado.  Ter documentado a intensificação do trabalho de cuidado e a capacidade manifesta pela empresa-plataforma de ir além do mero pareamento entre demandantes e ofertantes, passando a intervir no modo como o próprio trabalho se exerce, é a contribuição desta pesquisa para uma análise das formas assumidas pelo amplo e recente processo de digitalização do trabalho de cuidado no Brasil.
Por uma infopolítica das coleções: folclore e cultura material nas práticas documentárias do Instituto Brasileiro de Educação, Ciência e Cultura (IBECC)
Authors: Souza Jean Costa , Britto Clovis Carvalho
Published: December 2023

Este artigo analisa as práticas documentárias do Instituto Brasileiro de Educação, Ciência e Cultura (IBECC), tendo como estudo de caso algumas ações de sua Comissão Técnica de Folclore entre os anos de 1947 e 1951. Para tanto, investiga a institucionalização de uma rede de intelectuais no Brasil que defendeu uma perspectiva científica do Folclore, estimulada pela Organização das Nações Unidas para a Educação, a Ciência e a Cultura (Unesco). A partir de uma pesquisa qualitativa, baseada em revisão de literatura e análise documental, analisa-se como essa rede produziu uma infopolítica das coleções. Do mesmo modo, evidencia como mobilizou cultura material e práticas documentárias no intuito de autonomizar o campo do Folclore no Brasil nos primeiros anos de atuação da Comissão Técnica de Folclore.
O pretérito desfeito
Authors: Leite Renata Daflon
Published: December 2023

Texto com múltiplas imagens poéticas sobre as metamorfoses de uma escritura possível.
Educação literária: experiências dialógicas em uma escola da periferia de Manaus-Amazonas
Authors: Dantas Priscila Vasques Castro , Silva Iolete Ribeiro da
Published: December 2023

Este artigo apresenta, alinhado às dialogias de Freire (1967; 1996; 2020) e Bakhtin (2002; 2010) e ao letramento literário de Cosson (2006), em abordagem histórico-cultural, práticas do ensino de literatura pela perspectiva de um educar poético. A partir da observação participante, desenvolveram-se experiências dialógicas em uma escola de Ensino Médio da periferia de Manaus-Amazonas. Os resultados apontaram que uma educação literária ativa colabora para o desenvolvimento da percepção crítica, que viabiliza a expressão da subjetividade.
Representação histórica: uma análise do registro memorial de Xica da Silva na obra documental de Joaquim Felício dos Santos
Authors: Silva Ester Estevão da , Amorim José Edilson de
Published: December 2023

O presente artigo descreve e problematiza a representação memorialista da figura histórica Francisca da Silva de Oliveira na obra Memórias do Distrito Diamantino da Comarca de Serro Frio, de Joaquim Felício dos Santos. A partir de uma revisão bibliográfica que abarca discussões sobre a veracidade histórica dos acontecimentos registrados na historiografia oficial e a formulação das representações na História, objetivamos compreender como a representação de Xica da Silva, ao advir de construções discursivas e sociais, reflete e propaga os significados existentes no imaginário sócio-histórico brasileiro sobre mulheres negras. Para tanto, fundamentamos esta pesquisa em teóricos como Bakhtin e Voloshinov (2006), Pesavento (1995 ; 2012), Achard, Furtado (2003), Car (1996), Chartier (1988), Hall (2016), Le Goff (1990), Ricoeur (1994; 2007), Thompson (1998), entre outros. Com esta investigação constatamos como a formulação de respectiva personagem afro-brasileira, verificada na obra, evidencia as correntes de opinião, ideologias e movimentos sociais existentes em torno da raça negra, as quais, difundidas pelo discurso autoral, são tomadas como versão oficial dos acontecimentos e, consequentemente, como “verdades históricas”.
Avaliação de impacto da atividade “journal club” no conhecimento de metodologia científica entre os estudantes de medicina
Authors: Volinger Juliano Mota , Baracat Ana Carolina Coelho , Lourenço Eduarda Feitosa , Zeni Élen Maria Guimarães , Gomes Heitor Augusto
Published: December 2023

Introdução: O Journal Club é um ambiente para troca de informações dentro do contexto médico, diante de uma literatura atualizada e medicina baseada em evidências. Tendo em vista a importância da atualização constante de conhecimentos adquiridos e o cenário de isolamento social imposto pela pandemia da COVID-19, o evento Journal Club foi realizado virtualmente, com o objetivo de ampliar o entendimento sobre metodologia científica entre estudantes de medicina por meio da compreensão das diferenças de cada tipo de estudo da pirâmide de evidências a partir da leitura e discussão de artigos científicos. Metodologia: Estudo analítico, prospectivo e transversal realizado em outubro de 2021. O evento Journal Club ocorreu em nove aulas onde foram abordados cada tipo de estudoda pirâmide de evidência. A amostra foi composta por 20 estudantes de medicina. Um questionário foi aplicado no início e ao final do evento para avaliar o conhecimento dos participantes a partir das aulas ministradas, e foi dividido em duas partes, a primeira com dados de identificação do participante e a segunda com 19 questões sobre os tiposde estudos presentes na pirâmide de evidência. Resultados: Observou-se que, após a análise do questionário pré e pós-evento, dentre as 19 questões realizadas, houve um aumento de acertos em 17 entre as quais 3 obtiveram um valor estatístico significativo: questões 1 (p= 0,031), 15 (p=0,039) e 18 (p= 0,016). Discussão: Notou-se aumento dos acertos de questões entre o pré e pós-aulas, podendo indicar uma melhora no entendimento por parte dos acadêmicos acerca do assunto. Além disso, o estudo mostrou uma baixa atuação dos acadêmicos em pesquisas científicas (apenas 25% já se envolveram em algum projeto). Conclusão: A partir da análise do desempenho dos participantes nos questionários pré e pós-evento é possível afirmar que os estudantes de medicina conseguiram ampliar seu conhecimento sobre metodologia científica.
Comparison of 25-hydroxyvitamin D and bilirubin levels between patients with essential tremor and Parkinson’s disease
Authors: Vilaça Celmir de Oliveira , Leite Marco Antônio Araujo
Published: December 2023

Introduction: Differential diagnoses between essential tremor and Parkinson’s disease is challenging in some individuals, with both disorders sharing similarities. Considering these links, we hypothesized that both conditions have a similar profile for some antioxidant molecules, including 25-hydroxyvitamin D and bilirubin. Methods: Weperformed a cross-sectional study comparing serum levels of 25-hydroxyvitamin D and bilirubin in 31 ET patients, 38 PD, and 65 controls matched for age. We used the Fahn-Tolosa-Marin scale for the severity of tremors in the ET group. We used Hohen-Yahr and MDS-UPDRS part III scales in the PD group. In addition, we evaluated sociodemographiccharacteristics, including age, sex, ethnicity, years of study, duration of disease, and use of primidone.Results: We found no differences in serum levels for 25-hydroxyvitamin D or bilirubin subtype levels between the ET and PD groups. We found low levels of indirect bilirubin in the PD group compared to the controls. We did not find differences between ET and controls in all biomarkers of the study. Conclusion: ET and PD patients have similar profiles for 25-hydroxyvitamin D and bilirubin serum levels. The discovery of differences in oxidative stressbiomarkers in both conditions, mainly low-cost substances available clinically, can assist in the differential diagnosis and, in the future, prognostication and better therapy management.
Assessment of prenatal care performed in primary care: a cross-sectional study linked to a pregnancy cohort
Authors: Pereira Tayla Thais Jatahy , Rêgo Adriana Sousa , Aragão Francisca Bruna Arruda , Barbosa Janaina Maiana Abreu , Silva Yuri Alfredo Araújo Mendonça , Silva Thayane Leila Gonçalves da , Nitz Magali Kelli , Batista Marcia Rodrigues Veras , Firmo Wellyson da Cunha Araujo , Silva Flor de Maria Mendonça
Published: December 2023

Objectives: to assess the adequacy of prenatal care in primary care, to classify prenatal care according to the parameters of adequacy and to determine the factors associated with prenatal care in the pregnant women studied. Method: an analytical cross-sectional study of 205 pregnant women in ten basic health units in São Luís, MA. The qualitative variables were presented using absolute and percentage frequencies. Results: In the age variable, there was a predominance of the 21-30 age group (49.44%).  In the race/color variable, the highest prevalence was for pregnant women who declared themselves brown/other 99 (55.62%), with a lower prevalence for 6 consultations performed. With regard to the government benefits variable, the highest prevalence, 110 (61.80%), was for pregnant women who received them. Regarding marital status, 76.97% were pregnant women who had a partner, with a lower prevalence for 6 consultations, 137 (76.97%). As for schooling, there was a predominance of pregnant women with a high school education (68.18%). With regard to the start of prenatal care, 66.85% started prenatal care. With regard to the prescription of iron after starting prenatal care, there was a higher prevalence of pregnant women who used it (69.66%). Prevalence was also higher among pregnant women who underwent the following tests: cervical cancer screening, 147 (82.58%), ABO-RH system 129 (72.47%), complete blood count 121 (68.75%), and fasting blood glucose in the first trimester, 107 (60.11%). As for the anti-HIV test, the highest prevalence was for pregnant women who had not undergone the test, 103 (57.87%). With regard to the venereal disease research laboratory, the highest prevalence was among pregnant women who had undergone the test, 120 (67.42%). The highest prevalence of abnormal sediment elements was observed in pregnant women who underwent the test, 122 (68.54%). As for influenza vaccination among pregnant women, the highest prevalence was among those who had not been vaccinated 104 (58.43%). The highest prevalence of previous tetanus vaccination was among pregnant women who had not received the vaccine, 108 (60.67%). Hepatitis B vaccination was more prevalent among pregnant women who had received the vaccine 95 (53.37%). Pregnant women with no symptoms, with a diagnosis and without a negative diagnosis for Covid-19 were more prevalent, 117 (65.73%). Conclusion: The study allowed us to analyze that the quality of prenatal care in the health units where the study was carried out was unsatisfactory for some indicators, since the prevalence was less than 6 consultations.
Avaliação do risco de viés dos ensaios clínicos referenciados nas notas técnicas sobre os anticoagulantes orais diretos disponíveis no e-NatJus
Authors: Domingues Mara Luiza de Paiva , Almeida Nívea Aparecida de , Souza Denner Henrique Isaías , Baldoni Nayara Ragi , Rios Danyelle Romana Alves , Silvestre Carina Carvalho , Baldoni André Oliveira
Published: December 2023

Objetivo: Avaliar e classificar os riscos de vieses dos ensaios clínicos (EC) que compõem as NTs referentes à solicitação dos DOAC. Métodos: As NTs relacionadas à solicitação dos DOAC apixabana, dabigatrana, edoxabana e rivaroxabana foram selecionadas no website e-NatJus e, após exclusão das referências duplicadas, foi realizada uma análise dos EC utilizados para a redação das mesmas. O risco de viés dos EC (baixo, alto ou viés incerto) foi avaliado utilizando a ferramenta Cochrane Risk of Bias e os resultados foram adicionados no Review Manager 5.4. Resultados: Foram selecionadas 181 NTs, analisados 236 artigos e após aplicação dos critérios de inclusão, resultou em 28 EC analisados na íntegra. Nenhum dos EC ficou isento de viés. A maioria dos EC, 71% (20/28), apresentou baixo risco de viés em relação ao viés de atrito e viés de relato. Por outro lado, 61% (17/28) dos estudos não controlaram o viés de seleção, performance e detecção, uma vez que apresentam incertezas e alto risco de viés. Além disso, foi observado que 21% (6/28) dos EC apresentaram alto risco de viés para conflito de interesses. Conclusão: Os vieses presentes nos EC citados como referência das NT referentes a solicitação dos DOAC são significativos e comprometem a sua qualidade.
As meninas de Clarice Lispector e a tradução da infância em suas obras
Authors: Eleutério Rosangela Fernandes
Published: December 2023

O artigo tem por objetivo apresentar as personagens femininas infantis presentes nos textos de Clarice Lispector para compreender a infância das meninas dos anos 1920 - 1980 sob a ótica literária e histórica do Brasil durante esse período. A metodologia utilizada para a pesquisa foi uma revisão dos textos literários onde as protagonistas são meninas entre oito e dez anos, situadas em Recife, cidade onde a escritora viveu durante a infância. Para uma compreensão mais aprofundada da construção literária de Lispector, alguns teóricos são considerados como Alberto Manguel (2016), Maurice Blanchot (1969), Giorgio Agamben (2005, 2007, 2017). Georges Bataille (2016) e Judith Butler (2017) contribuem para uma compreensão filosófica sobre a escrita de si e a importância do resgaste da memória, enquanto Philippe Ariès (1973) faz algumas observações históricas sobre o contexto da época. O artigo tem como resultado um panorama sobre como as meninas, sobretudo a própria Clarice Lispector, aspiravam suas vidas como indivíduos autônomos, independentes, mas com o pesar da responsabilidade social que impunham às meninas e mulheres um padrão de comportamento que as angustiavam desde o fim da infância e início da puberdade, submetendo-as ao sistema patriarcal e conservador que lhes eram impostos.
Mário de Andrade para a jovem geração, de Nelly Novaes Coelho
Authors: Ribeiro Filho Paulo César
Published: December 2023

COELHO, Nelly Novaes. Mário de Andrade para a Jovem Geração. São Paulo: Saraiva S. A. Livreiros Editores, 1970.
Media Multitasking in Mixed Reality Learning Situations: What Determines Its Effectiveness?
Authors: Soldatova Galina U. , Koshevaya Anastasia G.
Published: December 2023

Background. Media multitasking (MMT) is common among adolescents, especially with the introduction of digital educational tools in mixed reality environments. However, there has been limited research on MMT in educational settings with electronic learning tools including augmented reality (AR). Objective. To study MMT in conjunction with metacognition, technology attitudes, and effectiveness of learning activities for 13–14 year olds in a mixed reality learning situation. Design. The experiment involved organizing learning activities in MMT format using digital tools, including AR. The MMT experimental group was given the option of searching the internet for information about a problem; the control group was given only a video, the e-textbook and AR application. Eye tracking measured task switching, while MMT efficiency was assessed by the number of completed tasks and test results. Metacognition was measured using the Metacognitive Awareness Inventory (MAI), and attitudes toward digital devices were examined using the Technology Attitudes Questionnaire. Results. Most of the adolescents (80%) preferred MMT, and no significant differences in test performance were found between the groups. Multitasking correlated with better cognitive control and metacognition scores and negatively correlated with technophobia. Learning activity effectiveness in mixed reality was assessed by the number and time of fixations on tasks in conjunction with metacognition and cognitive control. Interactive digital tools in education improve learning efficiency. Conclusion. Adolescents' preference for multitasking does not reduce learning productivity, but it does not guarantee success either. This suggests an internalization process of using digital technologies among adolescents. As a result, MMT may be gradually mastered as a new tool that is necessary for adaptation and success in an increasingly complex technological reality. Cognitive control and metacognitive planning significantly contribute to MMT efficiency, highlighting the importance of a conscious MMT strategy for effective learning.
Upper Colorado River Streamflow Dependencies on Summertime Synoptic Circulations and Hydroclimate Variability
Authors: Johnson Zachary F. , Stuivenvolt-Allen Jacob , Mahan Hayden , Meyer Jonathan D. D. , Miksch Matthew
Published: December 2023

The southwestern United States is highly sensitive to drought, prompting efforts to understand and predict its hydroclimate. Oftentimes, the emphasis is on wintertime precipitation variability, yet the southwestern United States exhibits a summertime monsoon where a significant portion of annual precipitation falls through daily convection activities manifested by a midtropospheric ridge of high pressure. Here, we examine synoptic patterns of the southwestern ridge through a k-means clustering analysis and assess how these synoptic patterns translate into streamflow changes in the upper Colorado River basin. A linear perspective suggests ∼17% of upper Colorado River discharge at the Lee’s Ferry, Arizona, gauge comes from summertime monsoon rains. The ridge of high pressure exhibits diversity in its intensity, structure, and position, inducing changes in moisture advection and precipitation. A ridge shifted north or east of its climatological center increases moisture and precipitation over the southwestern United States, while a ridge toward the south or northwest inhibits precipitation. A ridge east of its climatological center contributes to increased streamflow, whereas a ridge west or northwest of its climatological center decreases streamflow. Cooling in the central tropical Pacific and the Pacific meridional mode region favors an eastward shift of the ridge of high pressure corresponding to wet days. Eastern tropical Pacific warming favors a southward shift of the ridge corresponding to dry days. These results support an intermediate scale between climate forcing and summertime Colorado River discharge through changes in the intensity, structure, and position of the southwestern ridge of high pressure, integral to the U.S. Southwest hydroclimate.
Fuzzy proportional integral differential control of magnetorheological clutch torque based on bee colony algorithm optimization
Authors: Xiao Lu , Wang Xiao , Chen Fei , Li Aimin
Published: December 2023

As an intelligent transmission device, the magnetorheological (MR) clutch cannot realize its accurate torque control because it is difficult to establish its accurate torque control mathematical model. This paper designs a squeeze shear MR clutch. In order to achieve accurate torque control of the MR clutch, this paper proposes a fuzzy proportional integral differential (PID) control strategy based on the optimization of the bee colony algorithm. Based on the mechanical transmission experiment platform of the MR clutch, the performance of the torque control of the MR clutch is experimentally studied by using the real-time operating system Phar Lap ETS built by LabVIEW real-time module, it is found that the fuzzy PID control strategy based on bee colony algorithm can not only improve the torque control accuracy of the MR clutch by 70% compared to traditional PID control strategies but also increase the response speed by more than 50%.
Review of the effect cultural capital and subjective socioeconomic status on life satisfaction in Iran: the mediating role of health-promoting lifestyle and the moderating role of ethnicity
Authors: Gilan Nader Rajabi , Mohamadi Jamal , Irankhah Adel , Khezeli Mehdi , Zangeneh Alireza
Published: December 2023

Introduction

Health-promoting lifestyle can leads to improving the quality of life, life satisfaction, well-being and reducing the burden of health care in the society. This study was carried out to investigate the mediating role of health-promoting lifestyle and moderating role of ethnicity in the effect of cultural capital and subjective socioeconomic status on life satisfaction in Iran.

Methods

This cross-sectional study was conducted with 800 respondents in the cities of Kermanshah with Kurdish ethnicity and Tabriz with Azeri ethnicity. The data gathering tool was a questionnaire in five section including demographic checklist, cultural capital questionnaire (2015),Diener’s life satisfaction scale, and health-promoting lifestyle questionnaire (HPLP II), and socioeconomic status scale. Data were analyzed by SPSS and AMOS software.

Results

Life satisfaction had the highest correlation with the objective dimension of cultural capital (p < 0.001 r = 0.298). The direct standardized coefficient of the path of cultural capital to health-promoting lifestyle was 0.44 (P < 0.001). Also the direct standardized coefficient of cultural capital on Life satisfaction was 0.04 that was not significant. The standard coefficient of the path of cultural capital on life satisfaction through health-promoting lifestyle was 0.27(P < 0.001). Ethnicity variable did not moderate the effect of cultural capital on life satisfaction (p > 0.05).

Conclusion

The results of this study showed that paying attention to the concept of health-promoting lifestyle is a necessity to affect life satisfaction. It can play a role as a mediator for the path of cultural capital and socio-economic status on life satisfaction. This study also showed the role of ethnicity as a moderating variable in the relationship between socio-economic status and health-promoting lifestyle.