bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical significance of uremic toxin indoxyl sulfate and inflammation in the development of vascular calcification and cardiovascular complications in stage C3–C5D chronic kidney disease
Authors: Dzgoeva Fatima U. , Remizov Oleg V. , Goloeva Victoria G. , Ikoeva Zarina R.
Published: August 2023

Aim. To clarify the role of the uremic toxin indoxyl sulfate (IS) and inflammation in the development of vascular calcification and cardiovascular complications in chronic kidney disease (CKD).
Materials and methods. One hundred fifteen patients aged 25 to 68 years with CKD stage C3C5D were examined. Serum concentrations of IS, interleukin 6 (IL-6), tumor necrosis factor (TNF-), troponin I, parathyroid hormone were determined by enzyme immunoassay using kits from BluGene biotech (Shanghai, China), Cloud-Clone Corp. (USA), ELISA Kit (Biomedica, Austria).
Results. An increase in the serum concentration of IS, IL-6, TNF- was revealed, which was significantly associated with a deterioration in renal function and changes in the morphological and functional parameters of the heart and aorta.
Conclusion. High concentrations of IS, IL-6, TNF-, which are closely associated with an increase in renal failure and cardiovascular complications, indicate their significant role in vascular calcification, which underlies the damage to the cardiovascular system in CKD.
Clinical significance of the determination of antibodies to thrombospondin type 1 containing domain 7A (THSD7A) in membranous nephropathy
Authors: Kakhsurueva Patimat A. , Kamyshova Elena S. , Bobkova Irina N. , Stavrovskaya Ekaterina V. , Rudenko Tatiana E. , Andreeva Elena Y.
Published: August 2023

Background. Membranous nephropathy (MN) is an immunocomplex glomerular disease, which is the most common cause of nephrotic syndrome in adults. Numerous studies have established that autoantibodies against the target podocyte autoantigens, including the thrombospondin type 1 domain containing 7A (THSD7A), play a leading role in the development of idiopathic MN.
Aim. To evaluate the prevalence of anti-THSD7A autoantibodies (anti-THSD7A AB) in a group of Russian patients with MN.
Materials and methods. Serum titers of anti-THSD7A AB were tested in 61 patients with biopsy-proven MN and 12 healthy controls.
Results. The prevalence of anti-THSD7A AB was not differing significantly in patients with MN and in the control group (110.9 [71.63; 210.62] and 159.25 [125.64; 231.97] pg/ml, respectively; p=0.111). When comparing subgroups of anti-PLA2R-negative patients and patients who did not receive immunosuppressive therapy with the control group, there were also no statistically significant differences in the Anti-THSD7A AB levels (p0.05). In the MN group, 1 (1.6%) patient was anti-THSD7A-positive: a 60-year-old man with anti-PLA2R-negative MN and the presence of hormonally inactive adenomas of both adrenal glands and colon polyps (villous adenoma with focal moderate dysplasia, tubulo-villous and tubular adenoma with focal moderate severe dysplasia).
Conclusion. THSD7-associated MN is a rare variant of MN and is usually detected in PLA2R-negative patients. Screening for malignancies in THSD7A-positive MN patients is proposed.
Comparative characteristics of the complement system in patients with C3-glomerulopathy and atypical hemolytic uremic syndrome of chronic course who suffered an acute episode of thrombotic microangiopathy
Authors: Yurova Valeriya A. , Kozlovskaya Natalia L. , Bobrova Larisa A. , Kozlov Leonid V. , Andina Svetlana S. , Demyanova Kseniya A.
Published: August 2023

Aim. To compare changes in the complement system in C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after the relief of an acute episode of thrombotic microangiopathy.
Materials and methods. The study included 8 patients diagnosed with C3-GP and 8 with aHUS in remission. The blood levels of the complement system components were determined: C3, C4, C3a, C5a, factor H (CFH), factor B (CFB), membrane-attacking complex (MAC), antibodies to C3b (anti-C3b-AT), the level of hemolytic activity (CH50), the content of factor D (CFD) in the urine.
Results. C3 and CH50 levels were within the reference range in both groups, however, in the C3-GP group they were at the lower limit, and C3 level was significantly lower than in the aHUS group: 0.56 [0.44; 0.96] vs 1.37 [1.16; 2.52] (p=0.003). CFB increased level was detected in both groups, but in the C3-GP group it was significantly lower than in the aHUS group 275.1 [222.1; 356.6] vs 438.7 [323.3; 449.3] (p=0.010). C3a, C5a and MAC levels were increased in both groups, but the maximum was in the C3-GP group, and the MAC level in the C3-GP group was 2 times higher than that in aHUS, and these differences reached statistical significance 123 5556686 vs 56031294 (p=0.036). CFH and CFD levels was increased in both groups, but their highest values was in the aHUS group.
Conclusion. Alternative complement pathway activation signs were present in both groups of patients with complement-mediated nephropathies, regardless the stage of the disease. In C3-GP, alternative complement pathway activation was more pronounced than in aHUS after the relief of an acute episode of thrombotic microangiopathy.
Gıda Sektöründe Çalışanların Salgın Hastalık Farkındalıkları: Çanakkale İli Örneği
Authors: Dalyan Orkun , Canpolat Erdal , Öztürk Ömer Faruk , Pişkin Mehmet
Published: August 2023

Dinamik ve sürekli büyüyen gıda sektörü personellerinin bireysel hijyen davranışları, gıda güvenliğinin yanı sıra bulaşıcı hastalıkların (özellikle de koronavirüs hastalığı) salgın boyutuna geçmesinde önemlidir. Bu çalışmada, salgın sırasında, gıda sektörü personellerinin sağlık ve gıda güvenliği hakkında bilgi ve tutumları ayrıca bu salgının farkındalığına etki eden hijyen kriterleri incelenmiştir. Çanakkale ilinde gıda sektörü çalışanları ile 01.11.2022–01.12.2022 tarihleri arasında 42 ifadeyi içeren anket çalışması gerçekleştirilmiştir. Olasılıksız örnekleme ile seçilen 124 personelin anket verileri, literatürde konuyla ilgili önceki çalışmalarla karşılaştırılmıştır. Katılımcıların %31,5'i 26-35 yaş aralığındadır. Katılımcıların %48,4'ü lise düzeyinde eğitim seviyesine sahiptir. Katılımcıların %56,5’i sigara kullanmamaktadır. Katılımcıların %73,4’ü hijyen eğitimi almamış, %72,6’sının ise çocuğu yoktur. Araştırma sonuçlarına göre, medeni durum, yaş, eğitim düzeyi, hijyen eğitimi alma ve çocuğu olma değişkenlerinin salgın hastalık farkındalığı ve bireysel hijyen davranışı üzerinde olumlu yönde etkisi olduğu belirlenmiştir. Sağlık ve gıda güvenliği eğitimi ile gıda sektörü personellerinin hijyen tutum ve davranışı için kendi beyanlarına dayalı uygulamalarını iyileştirmek, gıda sektörünün durumunu iyileştirebilir ve toplum sağlığı için bulaşıcı salgın hastalıkları en aza indirebilir. Bu nedenle, politika yapıcıların gıda sektörü işveren ve personelleri için sürekli gıda güvenliği ve bireysel hijyen eğitimi için çevrimiçi bir sistem tasarlamalarına acil bir ihtiyaç vardır.
Kepler Light Curve Modeling of KIC 9788457
Authors: ALİÇAVUŞ Fahri
Published: August 2023

Eclipsing binary systems are significant objects for astrophysical studies since they offer more accurate fundamental stellar parameters (mass, radius). Therefore, in this study, the first binary modeling of KIC 9788457 is presented to estimated the fundamental stellar parameters of the system. The photometric data of the system were taken from Kepler that provides high-quality data. When the light curve was checked it was found that the more luminous massive component has a significant light contribution into total. Therefore, using the spectral energy distribution and also B-V values Teff value was estimated for the primary component. Utilizing this Teff value, the binary modeling of the system was carried out. As a result, fundamental physical parameters of KIC9788457 were obtained. The radius (R) and mass (M) values of the components are M1=1.89 ± 0.05 Msun and R1= 2.03 ± 0.02 Rsun for the massive component and M2=0.81 ± 0.02 Msun and R2= 1.74 ± 0.03 Rsun for the less massive component, respectively. Additionally, the distance of the system was determined to be 1407 ± 85 pc.
Complications of primary and recurrent buccal urethroplasty in men.
Authors:   N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of Health of the Russian Federation, Abdulaev I.A. ,   Moscow, Russia, Polyakov N.V. ,   Reconstructive Urology Group of the Department of General and Reconstructive Urοlοgy, N. Lopatkin Scientific Research Institute of Urology and Interven- tional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of Health of the Russian Federation; Moscow, Russia, Kazachenko A.V. ,   N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of Health of the Russian Federation; Moscow, Russia
Published: August 2023

Introduction. Recently, there has been a tendency to perform reconstructive-plastic interventions for the treatment of both primary and recurrent urethral strictures. Buccal urethroplasty is currently recognized as the «gold standard» for the urethral strictures treatment. However, despite a large number of works on operative correction of urethral strictures using the cheek mucosa, the issues of prevention and correction of intra- and postoperative complications of buccal urethroplasty have not been finally resolved. The purpose. Using the world literature, to stydy complications, methods of their prevention and correction for improving the efficiency of primary and repeated recοnstructive-plastic οperations on the urethra using free autograft of mucous membranes οth cheeks. Materials and methods. The literature review was made using bibliographic databases: Pubmed, Web of Sience, Science Direct, Scopus, Cyberleninka, eLibrary.ru and others for the period from 1990–2022. The following keywords were used: urethral stricture, buccal graft, complications of buccal urethroplasty, buccal urethroplasty, diagnosis of complications of buccal urethroplasty, treatment of complications of buccal urethroplasty, anastomotic urethroplasty, urethroplasty replacement. In total, 150 original publications were identified and analyzed, and 104 articles of them were selected for a literary review. Results. The analysis of complications of primary and repeated buccal urethroplasty was carried out, possible options for diagnosis and correction of complications of reconstructive plastic surgery on the urethra of men using the cheek mucosa were studied and the quality of life of patients after surgical treatment was analyzed. Conclusion. The analysis of the scientific literature on the results of the surgical treatment of primary and recurrent urethral strictures using buccal mucosa graft shows that at present there is no single clinical position that would clearly classify the emerging complications of this method of uretroplastics and contributed to the development of measures for their prevention.
Long-term results of the use of suburethral loop plastic surgery with tension control in the treatment of urinary incontinence.
Authors:   department of urology of A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Kasyan G.R. ,   Moscow, Russia, Sukhikh S.O. ,   Сity clinical hospital n.a. Spasokukotsky, Kupriyanov Yu.A. ,   Department of Urology of A.I. Yevdokimov Moscow State University of Medicine and Dentistry; Moscow, Russia, Stroganov R.V. ,   Department of Urology of A.I. Yevdokimov Moscow State University of Medicine and Dentistry; Moscow, Russia, Pushkar D.Yu. ,   Department of Urology of A.I. Yevdokimov Moscow State University of Medicine and Dentistry; Moscow, Russia
Published: August 2023

Introduction. Urinary incontinence is a disease that significantly reduces the quality of life in patients. Suburethral loop plasty is still the gold standard for the treatment of stress urinary incontinence, which is highly effective, but also has a number of possible postoperative complications. The purpose of this article is to evaluate the long-term results (after 4 years), the effectiveness and safety of the use of suburethral loop plasty with tension control. Materials and methods. Currently, there is no single way to adjust the tension of the hinge during its installation. At the Department of Urology of A.I. Yevdokimov Moscow State University of Medicine and Dentistry developed a device to control the tension of the loop, presented in the form of a self-absorbable pad (damper layer) located in the middle of a synthetic prosthesis. A prospective, comparative, randomized study that began in 2018 showed a high efficacy and safety profile for this device. When analyzing the results 1 year after the operation, the effectiveness of surgical treatment was 96%, the rate of postoperative complications in the form of infravesical obstruction was 2%, de novo urgency in the study group was 6%. In this study, we assessed long-term mid-term outcomes (over 4 years) through a telephone survey and filling in validated questionnaires (Urogenital distress inventory – UDI-6, Incontinence Impact Questionnaire – IIQ-7) among patients who underwent suburethral loop plasty with a loop tension control device. Results. The average score on the UDI-6 survey was 1.22 ±0.81, and 1.2±0.77 on the IIQ-7 survey. After a telephone survey after 48 months, there was a slight increase in scores, when compared with the results of the survey 12 months after surgical treatment, but not statistically significant (p>0.05). In the analysis of individual clinical cases after 48 months, 10 patients noted worsening of symptoms. Of these, 6 patients noted a recurrence of urinary incontinence when coughing, physical activity. Accordingly, the subjective effectiveness of surgical treatment over a 4-year follow-up period was 88%. Conclusions. Efficacy and safety data, in the medium-term follow-up of patients after suburethral loop plasty with tension control, are comparable to world data. However, further monitoring of patients in the long term is required.
Urethral strictures as a complication of transurethral prostate surgery.
Authors:   department of the clinic of urology Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia, Sinelnikov L.M. , Protoshchak V.V. ,   department and clinic of urology Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia, Kislitsyn P.O. ,   clinic of urology Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia, Gasanbekov T.N. ,   clinic of urology Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia, Proskurevich E.I. ,   clinic of urology Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia, Galiuk D.A. ,   department of urology Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russia
Published: August 2023

Introduction. The inclusion of antibiotic therapy into clinical practice in the second half of the 20th century radically changed the «etiological landscape» of urethral stricture disease. Against the background of a decrease in the proportion of inflammatory strictures, the introduction of new technologies, the spread of transurethral interventions in urology has led to an increase in the incidence of iatrogenic strictures. The purpose of this review is to systematize risk factors for urethral strictures after transurethral prostate surgery. Materials and methods. A search was made for the keywords «transurethral resection of the prostate», «urethral stricture», «iatrogenic urethral strictures», «urethral injuries» in the databases PubMed, eLibrary, Scopus, EMBASE, websites of professional associations. 58 publications were selected for review and analysis, 5 of which are domestic. Results. The influence of the following factors was analyzed: the method of energy supply, the type of energy, the method of removing prostatic tissue; instrument diameter and anatomical features of the patient; resection speed, operation time and volume of removed prostatic tissue; urinary tract infection; electrical damage; other risk factors for TURP. Conclusion. The proven factors include: the diameter of the instrument, operating times, urinary tract infection. Probable factors should be considered the anatomical features of the patient: «narrow urethra», a short penile suspensory ligament.
STUDIES ON RELATIVE TOXICITY OF CYPERMETHRIN IN COMBINATION WITH CERTAIN INSECTICIDES TO THE LARVAE OF Spodoptera litura Fabricius
Authors:   Ph.D Scholar, Department of Entomology, College of Agriculture , Hydarabad 500 030, V.L LALITHA KUMARI , C SUBBA RAO ,   Professor and Head, Department of Entomology, College of Agriculture , Hydarabad 500 030
Published: August 2023

Laboratory evauation of relative toxicity of cypermethrin alone and in combination with certain Insecticides endosulfan, monocrotophos and carbaryl at five concentrations for each instar studied against the larvae of Spodoptera litura Fabricius in five instars by bio-assay method to determine LC 50 and LC 90 values indicated that cypermethrin alone was the most toxic to the larvae of tobacco caterpillar In all instars followed by cypermethrin + carbaryl, cypermethrin + monocrotophos and cypermethrin + endosulfan.
CLIMATIC WATER BALANCE AT THE NAGPUR DISTRICT SITUATED IN THE DRY SUBHUMID REGION
Authors:   Department of Agricultural Engineering and Meteorology, Punjabrao Krishi Vidyapeeth, College of Agriculture, Nagpur 6440 001, S.R GHADEKAR
Published: August 2023

Water balance at the Nagpur district was computed from the climatic data. The mean annual precipitation and the potential evapotranspiration values were 124.83 cm and 172.08 cm respectively with the total monthly accumlated water deficit of 97.46 cm being partly met through storage charge and precipitation. Other elements of the water balance viz. water deficit, soil moisture recharge, water surplus etc. were worked out. It was observed that the soil moisture charge (40.45 cm) was useful for the crops during Rabi. Climatic conditions with respect to moisture were favourable during kharif and Rabl seasons but essential during summer irrigations.
P AND K UPTAKE PATTERN IN POTATO AS AFFECTED BY APPLIED NITROGEN
Authors:   Centre Potato Research Station, Shillong 793 009 Meghalaya, U.C SHARMA , M.R ARORA ,   Punjab Agricultural University Ludhina 141 004
Published: August 2023

Field experiments were conducted to study the effect of different rates of nitrogen application, in the absence and presence of FYM, on the tuber yield and uptake of P and K by potato at different stages of plant growth. Tuber yield and P and K accumulation by potato tubers increased significantly up to the application of 200 kg N/ha; whoreas significant Increase In P and K uptake of haulms was, Invariably, up to the application 150 kg N/ha at different periods of plant growth. Application of FYM increased P and K uptake of tubers and K uptake of haulms at all the stages of sampling. However P uptake of haulms was significant only at later periods of plant growth. The Increase in P and K uptake was mainly associated with increase. In the dry matter as a rosult of nitrogen application.
GENETIC DIVERGENCE FOR YIELD AND ITS COMPONENTS IN COMMON MILLET (Panicum miliaceum L.)
Authors:   Department of Agricultural Botany, Meerut University Meerut 250005, SINGH OMBIR , R.R GUPTA ,   Department of Plant Breeding and Genectics, C.S.A University of Agriculture and Technology, Kanpur
Published: August 2023

A sot of oighty two different strains of common millet (Panicum millacoum) collected from differont places was unod for natimation of gonolla silvergence. D² estimates based on 12 characters support that the differences in agroclimatic situations are not necessarily related to genetic divergence and thus the desirable diverso parents may not bo selected for hybridization on the basis of climatic regions.
EFFICIENCY OF NITROPHOSPHATES IN RICE-WHEAT SEQUENCE
Authors:   G.B.Plant University of Agriculture and Technology pantnagar U.P, B MISHRA , M.C JOSHI ,   G.B.Plant University of Agriculture and Technology pantnagar U.P, B.L SHARMA ,   G.B.Plant University of Agriculture and Technology pantnagar U.P, R SINGH ,   G.B.Plant University of Agriculture and Technology pantnagar U.P
Published: August 2023

Flold experiments were conducted on milllsols at Pantnagar to study the officacy of two nitrophosphate grades differing In P solubility vis-a-vis urea + triple super- phosphate (TSP) in rice-wheat sequence. Grain, yield response of rice to both the nitrophosphate grades was similar but its magnitude was less than the reponse to uroa TSP. The relative agronomic effectiveness of nitrophosphate decreased with Increasing level of application. Total N and P uptake by rico was also loss in the plots fertilized with either grade of nitrophosphate as compared to urea + TSP plots. The residual effects of nitrophosphates on wheat were however more or less similar to urea TSP when additional N was adequately supplied.
EFFECT OF PLANT EXTRACTS AND OILS ON RICE YELLOW DWARF INFECTION
Authors:   Department of Plant Pathology,Tamil Nadu Agricultural University Coimbatore  641 003, G NARASIMHA RAO , P NARAYANASAMY ,   Department of Plant Pathology,Tamil Nadu Agricultural University Coimbatore  641 003
Published: August 2023

The efficacy of plant products and oils in reducing the infection of rice by yellow dwart MLO was tested. Leaf extracts of young and matured leaves of Neem, Mirabilis jalapa, Catharanthus roseus, Maize and Nerium sp were applied on TN 1 rice plants. The infective leafhoppers were caged on treated and control plants at 1, 24, 48 and 72 hr after applications of leaf extracts. Neem leaf (both matured and young) recorded low infection (40%) as compared to other treatments and control (82.2%). The incubation period in the neem leaf extract treated plants increased to 40.3 days as against 28.5 days in control. The reduction in infection and increase in incubation period were observed more significantly in plants inoculated one hr after the treatment than in plants inoculated at 24, 48 and 72 hr after the treatment. Of the three oils tested namely, Neem, pungam and illupai oils, Neem oil recorded lower per cent infection (13.3%) as compared to illupai oil (26.7%), pungam oil (20.0%) and control (82.2%). The incubation period was also increased significantly in the plants treated with oils. As in the case of leaf extracts, the favourable effect on infection and incubation period was reduced as the interval between application of oils and inoculation increased.
EFFECT ON DATES OF SOWING AND GROWTH PATTERNS OF PIGEONPEA [Cajanus cajan (L) Millsp.] IN WINTER SEASON
Authors:   Department of Agronomy, Bidhan Chandra Krishi viswavidyalaya,Kalyani Nadia ( W.B) 741 235, A.M PUSTE , P.K JANA ,   Department of Agronomy, Bidhan Chandra Krishi viswavidyalaya,Kalyani Nadia ( W.B) 741 235
Published: August 2023

The investigation was carried out duri g winter seasons of 1980-81 and 1981-82 at the University Farm, Kalyani to study the r sponse of 20(105), 5(124), HY3C and Bahar varieties of pigeonpea to different dates of s wing (September 29, October 14 and 29 and November 14 and 30). Variety Bahar record maximum LAI, leaf, stem, pad, total dry matter per plant and also CGR, whereas variety 20( 05) had the minimum LAI, leaf, stem, pod, total dry matter per plant and CGR. Date of sowing ignificantly influenced the dry matter production of leaf, stem and pod, LAI and CGR. Septem er 29 sowing was found superior to other dates of sowing in respect to all the characters stu ied.
VHC 2 A NEW TXD HYBRID COCONUT FOR TAMIL NADU
Authors:   Coconut Research Station, Veppankulam 614 906  Tamil nadu, T.K RAMACHANDRAN , T.S RAVEENDRAN ,   Coconut Research Station, Veppankulam 614 906  Tamil nadu, T RAMANATHAN ,   Coconut Research Station, Veppankulam 614 906  Tamil nadu, I HENRY LOUIS ,   Coconut Research Station, Veppankulam 614 906  Tamil nadu
Published: August 2023

A new coconut hybrid VHC 2 was synthesised by combining ECTX MDY. This hybrid possessed high yield potential than the local ECT in terms of nut and copra yields. VHC 2 is characterised by low values for bunch buckling and leaf drooping which are the disadvantages commonly met in T x D hybrids. VHC 2 is recommended for commercial cultivation in Tamil Nadu.
EFFECT OF LOW LIGHT INTENSITY ON GROWTH AND PRODUCTIVITY OF IRRIGATED RICE (Oryza sativa L.) GROWN IN CAUVERY DELTA REGION
Authors:   Professor of Crop PHysiology, Tamil Nadu Rice Research Institute, Aduthurai - 612101, Tamil Nadu, M THANGARAJ , V SIVASUBRAMANIAN ,   Professor of Agricultural Botany, Annamalai University
Published: August 2023

Irrespective of varieties, low light intensity significantly increased the plant height, leaf area index (LAI) and total leaf chlorophyll content while significant reduction was evident in respect of total dry matter, panicle number, spikelet number, filled grains and grain yield. It was considered that low light intensity during samba/thalaci season, appearing particularly from panicle initiation to harvest was an important constraint for higher productivity since yields as low as 3.19 to 4.28 tha were recorded with varieties which yielded 5.00 to 5.84 tha under normal light intensity conditions. Among several varieties, Ponni appeared to be more tolerant with least reduction in grain yield (15.9%) under low light intensities thus more suitable for samba/thaladi season followed by White Ponni, Co 43 and IR 20.
NOTÍCIAS DE UM FASCISMO À BRASILEIRA
Authors: Motta Kássio
Published: August 2023

Este texto tem o objetivo de mostrar que as relações entre “situação social”, “comportamento político” e a capacidade de descrever o estado de coisas, no Brasil do século XXI, passam pela compreensão da colonialidade nossa de cada dia. E pelo entendimento do papel da nossa grande imprensa nacional. Grupos capitalistas e indústrias a (re)produzirem notícias e subjetividades. “Sem tabus”, garantem. Para tentar construir uma possível compreensão da situação, busco responder a algumas questões: Como podemos definir fascismo? Há um fascismo à brasileira? Por que nunca ou pouquíssimo se ouviu falar sobre fascismo na imprensa nacional até 8 de janeiro de 2023? Como a imprensa capitalista se portou diante do fascismo do estado até então? Deu-se a devida dimensão sobre os genocídios de populações negras e nativas ? formalmente denunciados nacional e internacionalmente? Pode-se falar em autocensura?
IGNORÂNCIA BRANCA E SUAS CORRELAÇÕES COM O RACISMO AMBIENTAL NO BRASIL
Authors: Silva Bruna Schneid da
Published: August 2023

A vulnerabilidade, ou ainda, a precariedade, são conceitos amplamente discutidos entre as teóricas e teóricos que se preocupam em analisar as relações de poder. Dentro do mainstream das teorias epistemológicas analíticas, as relações de poder e quaisquer relações morais e políticas da construção dos conhecimentos localizados não são considerados relevantes para a verdade. Nesse sentido, a ignorância, ou ainda a falta de conhecimento, se manteve fora dos holofotes da epistemologia analítica. O conhecimento moderno/colonial reforça de forma desigual a distribuição de credibilidade aos falantes. Defendo aqui que existem formas de vulnerabilização que estão diretamente correlacionadas às condições ambientais. As questões que este artigo visa discutir são: por que a parte mais pobre da população é sistematicamente prejudicada por problemas ambientais? E ainda: qual o papel da ignorância em tal vulnerabilidade? Para isso, analisaremos a noção de ignorância branca enquanto uma forma de manutenção do racismo ambiental no Brasil.
Compilado de Ciências Biomédicas - Volume 2
Authors: Gonçalves Heloísa Maria Lima , Oliveira Luciana Coelho Carvalho , Moura Angela Gabriela de Araújo Costa , Sousa Hiran Reis , Assunção Raissa Guará , Fontenelle Pedro Henrique Cunha , Fontoura Caroline Cunha , Maranhão Marina Cristine Silva
Published: August 2023

Nesta obra os organizadores realizaram uma compilação de vários documentos e artigos sobre Biomedicina, contribuição, pesquisa científica, estudo de caso direcionando o seu conteúdo para demonstrar os avanços atingidos na área.
The Chaotic Four-Body Problem in Newtonian Gravity - II. An ansatz-based approach to analytic solutions.
Authors:   , Cecil Leigh Nathan William
Published: August 2023

La interacción entre cuatro cuerpos es de vital importancia para comprender la evolución de los cúmulos estelares. Esto se debe a que se ha demostrado que estas interacciones ocurren regularmente en cúmulos con altas fracciones de estrellas binarias (por encima de ∼ 10%), y son fundamentales para decidir el tiempo de evolución del sistema en densidades centrales grandes. En este trabajo continuamos nuestro análisis del problema caótico de los cuatro cuerpos presentando un tratamiento analítico general basado en un ansatz usando mecánica estadística, donde cada resultado del problema de los cuatro cuerpos se trabaja y considera como una variación del problema de los tres cuerpos (por ejemplo, cuando se producen dos estrellas individuales, cada evento de eyección se modela como una interacción de tres cuerpos asumiendo que las eyecciones están bien separadas en el tiempo). Esta es una generalización del tratamiento en mecánica estadística del problema de los tres cuerpos desarrollado por primera vez por Monaghan (1976a). En nuestro caso, nos centramos en la interacción de dos sistemas binarios, después de lo cual dividimos nuestros resultados en tres posibles escenarios (2+2, 2+1+1 y 3+1). Para cada resultado, aplicamos un enfoque basado en un ansatz para derivar funciones de distribución analíticas, las cuales describen las propiedades de los productos de las interacciones caóticas de los cuatro cuerpos para partículas puntuales. Para probar nuestras distribuciones teóricas, realizamos un conjunto de simulaciones de dispersión en el límite en que las partículas puntuales son de igual masa usando FEWBODY. Finalmente, comparamos nuestras distribuciones teóricas con las simulaciones para cada escenario en particular, encontrando de manera consistente un buen acuerdo entre ambas en los escenarios en que sean comparables.
Biomarcadores Proteicos. Hacia el desarrollo de metodologías para la estimación del intervalo post mortem (IPM) en osamentas humanas.
Authors:   , Tarifeño Saldivia Estefanía
Published: August 2023

La estimación del intervalo post mortem (IPM) resulta todo un desafío, más aún cuando se enmarca en contextos forenses que requieren establecer la data de muerte de restos en etapas tardías de descomposición. Actualmente, las investigaciones tafonómicas buscan proporcionar marcadores que permitan desarrollar estimaciones precisas y objetivas, de manera tal que sean admisibles en los procesos judiciales. En dicho esfuerzo, los estudios de degradación proteica han resultado prometedores. La presente investigación exploró las dinámicas del proteoma de osamentas humanas a distintos IPM en términos de diversidad y abundancia, a fin de evaluar si estas son informativas para la estimación de la data de muerte en restos óseos. Para ello se tomaron muestras de tejido cortical de costillas y tibias de 15 individuos masculinos con edades entre 20 a 50 años provenientes de contextos cadavéricos y de resacas de cementerio, cuyos IPM corresponden a 1 año, 15 años y 20 años en muestras de costillas, y con IPM de 15 y 20 años para muestras de tibias. Los resultados proteómicos indican que muestras tempranas (IPM 1 año) exhiben una mayor diversidad y abundancia de proteínas que muestras tardías (IPM 15 y 20 años), identificando 7 proteínas discriminantes entre ambos IPM. Se observó que otras 7 proteínas siguen un decaimiento gradual y progresivo en su abundancia que se correlaciona significativamente con el aumento del IPM. A su vez, se evidenció que las propiedades estructurales de las proteínas como el peso molecular y composición aminoacídica podrían ser cruciales para la preservación post mortem.
An updated phytochemical and pharmacological review on Malabar Spinach (Basella alba or Basella rubra)
Authors: G. Jyothi Reddy  , T. Reddi Madhavi  , Ch. Appa Rao  , S. Nithya  , P. Niranjan Rao
Published: August 2023

Cancer, autoimmune diseases, microbial infections and oxidative stress are becoming unavoidable threats in recent times. Despite advances in conventional treatments such as surgery, radiotherapy and chemotherapy, problems related to these therapies such as side effects, opportunistic infections and the development of drug resistance remained unsolved. Therefore, the need of the hour is to develop novel treatment modalities using plant derivatives which act as effective therapeutic agents and have minimal side effects. Basella alba is one such plant which contains various phytochemicals viz. flavonoids, alkaloids, phytosterols, tannins and triterpenoids etc., which helps in curing various diseases. The main aim of the present review is to highlight the phytochemical and pharmacological investigation carried out on the plant so that the more pharmacological studies could be conducted to investigate the untapped potential. Based on the published evidences on various databases, findings suggest that various parts of B. alba are used as antioxidant, anticancer, antibacterial, anti-inflammatory, antiulcer and many other diseases. Finally, it can be concluded that B. alba may be appealed as a good source of pharmacologically active compounds to develop new drugs.
Effect of combined seeds of Sesemum indicum and Moringa oleifera compounded feed on liver function markers of alloxan-induced diabetic albino rats
Authors: GERALDINE OBUMNEME UDEBUNU  , KIZITO MUNACHISO IHEANACHO  , FAVOUR NTITE UJOWUDU  , KELECHI LIGHT EKEKE  , MARYANN UGOCHINYERE UDEBUNU  , TIMOTHY CHIKE EZEOKEKE
Published: August 2023

This study investigated the effect of combined seeds of Sesemum indicum (SI) and Moringa oleifera (MO) on liver function markers in alloxan-induced diabetic albino rats. 54 albino rats were divided into 9 groups of 6 animals each. Group 1 served as the normal control and received standard feed diet, Group 2 (Diabetic control) received intraperitoneal injection of 140mg/kg of Alloxan, Group 3 (Positive control) received 5mg/kg of glibenclamide, Group 4; diabetic rats fed diet containing 15% of SI. Group 5; diabetic rat fed with 15% of MO diet, Group 6; diabetic rat fed with combination of 15% SI and 15% MO compounded diet. Group 7; diabetic rat fed with 30% of SI diet. Group 8; diabetic rat fed with 30% of MO diet. Group 9; diabetic rat fed with combination of 30% MO and 30% SI diet. The Feed was compounded and was given daily for 14 days. Serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total protein, albumin, and bilirubin were estimated to assess hepatic function using spectrophotometric method. Results showed a significant decrease in ALT, ALP, AST, and bilirubin levels when fed with compounded feeds at (p<0.05). Also feeding of diet with combined seeds significantly (P<0.05) increased the total protein and albumin in induced rats. Overall, compounded feed with combined seeds of SI and MO exhibited a promising anti-diabetic activity and normalized the liver enzyme activities which appeared comparable to the control glibenclamide in alloxan-induced diabetes hence, may be recommended for treatment/management of diabetes mellitus.
Green Zeolite Synthesis Assisted with Plants Extract
Authors:   Universiti Tun Hussein Onn Malaysia, Tee Dee , Azhar Faiz Hafeez ,   Universiti Tun Hussein Onn Malaysia, Harun Zawati ,   Universiti Tun Hussein Onn Malaysia, Hussin Rosniza ,   Universiti Tun Hussein Onn Malaysia, Syamsol Bahri Syamsutajri ,   Universiti Tun Hussein Onn Malaysia, Hairom Nur Hanis Hayati ,   Universiti Tun Hussein Onn Malaysia, Ainuddin Ainun Rahmahwati ,   Universiti Tun Hussein Onn Malaysia, Basri Hatijah ,   Universiti Tun Hussein Onn Malaysia, Kamdi Zakiah ,   Universiti Tun Hussein Onn Malaysia
Published: August 2023

The study explores the hydrothermal synthesis of zeolite using kaolin clay from Perak in the presence of two different reduction mediums, namely turmeric extract and ginger extract, and a 2M NaOH solution, measuring their efficiency and potential for green synthesis. Before the zeolite synthesis and transformation, the kaolin clay was heated at a temperature of 650 oC for 4 hours in the furnace to produce the metakaolin phase. The synthesized zeolite involves the reaction of NaOH with potential reduction plant extracts to assist the transformation of zeolite. The characterization of the synthesized particles after being ground into a fine powder and subsequently undergoing testing and characterization via X-ray diffraction (XRD) revealed the existence of zeolite phases in both plants with slightly different zeolite compositions. Synthesis mixtures with turmeric plants show better composition of the zeolite phase as compared to ginger mixtures. Scanning Electron Microscope (SEM) and Energy Dispersive X-Ray Analysis (EDX) also revealed that the synthesized product using turmeric plant extract was able to produce zeolite LTA with a good grade. The current experimental work shows the possibility of obtaining a well crystalline zeolite from Malaysian kaolin, assisted with plant extract reduction medium.
Metabolic model for laboratory control of anti-ischaemic therapy effectiveness: a case study of nicorandil
Authors: Subbotina T. F. , Kudaev Yu. A. , Lokhovinina N. L. , Alugishvili M. Z. , Abesadze I. T. , Titenkov I. V. , Chernyavskiy M. A. , Panov A. V. , Zhloba A. A.
Published: August 2023

Scientific relevance. A key anti-ischaemic mechanism of some medicinal products involves their effects on the metabolism of endothelial vasodilators, particularly the synthesis of nitric oxide from arginine and its precursor citrulline.

Aim. The study was aimed to determine whether the plasma time course of guanidine derivatives (arginine precursors) is applicable to laboratory control of anti-ischaemic therapy effectiveness using a single oral dose of nicorandil in patients with coronary heart disease as a case study.

Materials and methods. The authors used high-performance liquid chromatography to determine metabolites. Blood samples for analysis were obtained from 30 patients with angina pectoris (Grade II–III, Canadian Cardiovascular Society) and 30 healthy donors. All the study participants received a single oral dose of 20 mg nicorandil after 10 h of fasting.

Results. At baseline, patients showed significantly higher plasma citrulline levels than donors. However, the elevated levels decreased to the healthy range after nicorandil administration. Plasma arginine levels in patients showed a statistically significant increase following nicorandil administration. Plasma homoarginine levels in patients remained reduced both before and after dosing. Nicorandil did not influence elevated levels of the endogenous nitric oxide synthase inhibitor (asymmetrical dimethylarginine).

Conclusions. In addition to the established mechanisms responsible for altering cell metabolism, nicorandil enhances the contribution of citrulline to arginine resynthesis. It is reasonable to include citrulline and arginine, which are involved in the vasodilator response, in model schemes for laboratory control of the effectiveness of anti-ischaemic therapy.
A Comparative Analysis of Ensemble Learning Methods on Social Media Account Detection
Authors: VAROL ARISOY Merve , TUNÇ ABUBAKAR Tuğba
Published: August 2023

Today, social media platforms usage and benefiting rate from these environments are increasing. This rapid spread of social media has also allowed the emergence of fake accounts. Fake accounts are generally created to implement malicious activities through another user account or to spread incorrect information. To prevent the detriment that this situation may cause to real individuals, an effective fake account detection was carried out by using ensemble learning methods (Bagging, Boosting, Stacking, Voting and Blending) in this study. These methods were combined with various machine learning algorithms to measure their effectiveness in detecting fake accounts. The experimental results suggested that Bagging technique attained an accuracy level of 90.441%, Stacking technique 89.706%, Voting technique 88.971% and the Blending technique attained 88.235% in the test phase. While for the Boosting methods, XGboost technique attained accuracy level of 86.765%, whereas the AdaBoost outperformed it with an accuracy level of 91.912% in the test phase. The extant results demonstrates that ensemble learning methods combined with machine learning algorithms are efficient in detecting fake social media accounts. It is considered that additional studies with larger datasets alongside the usage of different ensemble methods can further improve the accuracy of the detection process.
Livid about Liberalism: Putin, State Controlled Television and Kremlin Portrayals of Liberalism
Authors: Sykes Adam
Published: August 2023

Russian President Vladimir Putin has demonstrated a keen interest in questions of history and political theory over his more than two decades at or near the apex of Russian power. These questions became particularly salient in Russia’s political discourse after Putin returned to power in 2012 and inaugurated the so-called “conservative turn.” This paper examines how Putin characterized liberalism between his return to power in 2012 and the start of the “special military operation” in Ukraine on 24 February 2022. It contends that, over this decade, Putin consistently positioned himself as a moderate critic of Western liberalism as opposed to an uncompromising ideologue, even after the 2014 Ukraine crisis. To highlight this tendency, this paper simultaneously examines two prominent Russian state television personalities – Dmitrii Kiselev and Vladimir Solov’ev – who have used strident rhetoric in describing Western liberalism, notably after the 2014 crisis in Ukraine.
Legitimacies Conflict: The Evolution of Perceived Legitimacy in Modern Russia
Authors: Ternov Nikolay , Mikhailov Dmitry
Published: August 2023

The paper proposes a new interpretation of the evolution of legitimacy in Russia based on two pillars: the sociological tradition of legitimacy research, and David Easton’s typology. In this regard, the political process in Russia can be perceived as a conflicting coexistence of various legitimacies. The very conflicting variations begin to prevail in the public consciousness at certain stages of modern Russia existence, not forcing out each other completely.

The trends that prevailed in the definition of Russian statehood allow us to distinguish three stages in the legitimacy evolution, which conditionally correspond to each decade of the existence of modern Russia: the “ideological” stage (90s-00s) and the “structural” one (00s-2012). We define the contemporary period as “personal” that emerged after 2012. The current political crisis in Russia is interpreted as a conflict of “structural” and “personal” legitimacy, that is unfolding against the backdrop of attempts by the authorities to compensate for the lack of trust, with technologies of “quick” self-legitimacy.
The 1999 Moscow Bombings Reconsidered
Authors: Otto Robert
Published: August 2023

This paper examines the evidence that the Federal Security Service (FSB) was behind the 1999 apartment bombings to bring Vladimir Putin to power. Although this version of events may prove true, this article posits that evidence for this assertion is lacking and that current arguments for this version have considerable flaws. In addition, although the official version, despite its weaknesses may also well prove true, the paper posits an as yet an unexplored version to explain the bombings as an “inside job.” The paper looks at the atmosphere prevailing in Moscow that Fall and Berezovskii’s purported role in bringing Vladimir Putin to power which is often overstated. Nonetheless, Putin’s failure to conduct a proper investigation of the bombings makes him complicit in them.
Leibniz’s Causal Road to Existential Independence
Authors: Flattery Tobias
Published: August 2023

Leibniz thinks that every created substance is causally active, and yet causally independent of every other: none can cause changes in any but itself. This is not controversial. But Leibniz also thinks that every created substance is existentially independent of every other: it is metaphysically possible for any to exist with or without any other. This is controversial. I argue that, given a mainstream reading of Leibniz’s essentialism, if one accepts the former, uncontroversial interpretation concerning causal independence, then one ought also to accept the latter, controversial one concerning existential independence. This is a new way to defend the ‘existential independence’ interpretation. Moreover, this defense provides a new approach for defending the broadly ‘non-logical’ interpretive camp in the longstanding debate over Leibniz’s views on incompossibility, against perhaps the strongest objection leveled by advocates of the opposing broadly ‘logical’ interpretation.
Hidden nonlinearity of weak field sound wave in (2+1)-dimensional space-time
Authors: Hadi Miftachul , Hermawanto Denny
Published: August 2023

We propose that the weak field sound wave equation derived from Newton's second law of gravitation in (2+1)-dimensional empty space-time, a linear equation, could have hidden nonlinearity. This hidden nonlinearity is written using the Clebsch (scalar) variables.
Exploration in 4-year-old children is guided by learning progress and novelty
Authors: Poli Francesco , Meyer Marlene , Mars Rogier B. , Hunnius Sabine
Published: August 2023

Humans are driven by an intrinsic motivation to learn, but the developmental origins of curiosity-driven exploration remain unclear. We investigated the computational principles guiding 4-year-old children's exploration during a touchscreen game (N=102, F=49, M=53). Children guessed the location of characters that were hiding behind a hedge following predictable (yet noisy) patterns. Children could freely switch characters, which allowed us to quantify when they decided to explore something different and what they chose to explore. Bayesian modelling of their responses revealed that children selected activities that were more novel and offered greater learning progress. Moreover, children’s interest in making learning progress correlated with better learning performance. These findings highlight the importance of novelty and learning progress in guiding children’s curiosity-driven exploration.
Exploring the Nexus of University Enrollment Expansion, Tuition Fees, and Educational Equality
Authors: Liu Fengcun , Li Shumei
Published: August 2023

The expansion of university enrollment and the implementation of tuition fees have become focal points of discussion in both current educational practices and theories. While increased university enrollment offers more opportunities for higher education, the high cost of tuition fees has pushed economically disadvantaged students to the brink of discontinuing their studies, prompting widespread concerns about educational equality.