bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality Analysis of Outpatient Care at Kepulauan Seribu General Hospital based on Malcolm Baldrige Criteria
Authors: Pramana Ghamal Ahmad , Ayuningtyas Dumilah
Published: August 2023

The outpatient unit is a part of the hospital. The outpatient unit has an important role because it is the first door or medium for contact and interaction with service users or patients. Outpatient care is also an entry point for other inpatient services. Seribu Islands Regional General Hospital as the only hospital in the Thousand Islands region has not yet reached the required minimum outpatient service standard. This study aims to analyze the quality of outpatient care at Seribu Islands Hospital with the criteria of Malcolm Baldrige. The criteria for evaluating organizations are based on seven criteria, namely leadership, strategic planning, customer focus, measurement, analysis, and knowledge management, staff focus, process management, and performance results. This study uses a descriptive analytic research design with quantitative and qualitative approaches. The data collected was obtained through questionnaires, in-depth interviews, and document review. The results of the study using the Malcolm Baldrige Criteria showed that Seribu Islands Hospital won a score of 379.83 out of a maximum of 1000. This means that for hospital performance assessment based on MBNQA, Kepulauan Seribu Hospital won the average title and was included in the Early Improvement category (point scale 376-475 ). Early improvement means that Seribu Islands Hospital is in a position of early stage improvement in the health service sector. For this reason, it is recommended that Thousand Islands Hospital develop strong leadership and good teamwork in order to determine the right strategic plan.
El efecto de la pandemia de COVID 19 sobre la evaluación del conocimiento matemático. Actuaciones que intentan persistir después de la pandemia
Authors: Delgado Pineda Miguel
Published: August 2023

Evaluar al estudiante es algo esencial en la tarea docente, ya que esto influye en el control de las garantías que todo proceso educativo debe afrontar. En este trabajo presentamos la experiencia evaluadora de una materia de matemáticas en la Universidad Nacional de Educación a Distancia de España, una universidad no presencial, y en un momento álgido de pandemia. La propuesta evaluadora consiste en un sistema de colaboración en las tareas de evaluación que se desarrollo en el curso 2020-21. Esta fue aplicada en estado de pandemia donde estaba prohibido por la Administración Educativa realizar pruebas en modo presencial. En ese curso se registró el máximo de estudiantes presentados a las pruebas de esa materia de los últimos 12 cursos.
Orientasi Kewirausahaan Dan Modal Sosial: Studi Literatur
Authors: Wahyudi Raymond
Published: August 2023

Orientasi kewirausahaan (OK) umumnya telah digunakan sebagai faktor pendukung kinerja usaha namun belum cukup penelitian untuk membuktikan faktor yang berperan untuk membentuk OK. Modal sosial (MS) sebagai elemen penting bagi wirausaha namun terdapat hubungan yang tidak konsisten terhadap OK. Penelitian ini bertujuan untuk menemukan research gap yang dapat dikembangkan pada penelitian selanjutnya dengan menjabarkan kerangka berpikir teoritis mengenai MS yang dihubungkan dengan OK dan juga untuk mengetahui gambaran penelitian yang telah dilakukan di Indonesia selama 5 tahun terakhir yaitu tahun 2017 hingga 2022. Melalui tujuan penelitian tersebut maka metode penelitian yang digunakan adalah metode studi literatur melalui artikel yang dikumpulkan berdasarkan pencarian dari database garuda kemdikbud. Maka berdasarkan artikel yang telah diidentifikasi dan memenuhi kriteria yang ditentukan, hasil penelitian dapat disimpulkan bahwa MS perlu dimiliki oleh wirausahawan untuk meningkatkan kinerja usaha dengan dukungan dari OK supaya memperoleh peluang yang dapat digunakan untuk pertumbuhan bisnis yang berkelanjutan dengan membangun aliansi strategis yang mendukung satu sama lain. Selain itu, juga dapat disimpulkan bahwa MS memiliki peran yang penting terhadap peningkatan OK terutama bagi Usaha Kecil, Menengah dan Mikro (UMKM) di Indonesia yaitu dengan adanya MS yang diiring dengan persamaan tujuan dan budaya untuk mengurangi kemungkinan konflik yang terjadi sehingga mempermudah para wirausahawan dalam jaringan tersebut untuk menggunakan sumber daya, pasar dan teknologi. OK juga memiliki peran penting bagi suatu bisnis untuk memiliki kinerja yang semakin baik melalui kemampuan untuk memperoleh peluang baru dan mengalami pertumbuhan yang berkelanjutan. Penelitian ini diharapkan dapat berkontribusi bagi pengembangan studi kewirausahaan selanjutnya.
Predicting HVAC-Based Demand Flexibility In Grid- Interactive Efficient Buildings Utilizing Deep Neural Networks
Authors: Campodonico Avendano Italo Aldo , Moazami Amin , Dadras Javan Farzad , Najafi Behzad
Published: August 2023

Grid-interactive efficient buildings (GEBs) can provide flexibility services to the grid through demand response. This paper presents a novel predictive modeling methodology to estimate the availability of electrical demand flexibility in GEBs under demand response schemes. In this context, a physics-based energy simulation model of a reference building, considering the cooling demand in the summer season as the flexible load, is utilized. Accordingly, the impact of increasing the indoor setpoint temperature by 1.5 °C (for a maximum of 3 hours per day), which enables the demand side flexibility with a reduction of the cooling equipment’s electrical load, is simulated. Next, each demand response event is gathered, sorted, and then used to train the model to predict similar future events over the same time horizon in the following days. For this purpose, a deep neural network model trained using an expanding window training scheme is utilized to predict (15 minutes before the event) the load in the next 3 hours while undergoing the flexibility scenario. It is demonstrated that, with four months of training data, the model offers a promising prediction accuracy with a Mean Absolute Percentage Error (MAPE) of 3.55%.
aMLLibrary: An AutoML Approach For Performance Prediction
Authors: Guindani Bruno , Lattuada Marco , Ardagna Danilo
Published: August 2023

aMLLibrary is an open-source, high-level Python package that allows the parallel building of multiple Machine Learning (ML) regression models. It is focused on performance modeling and supports several methods for feature engineering/selection and hyperparameter tuning. The library implements fault tolerance mechanisms to recover from system crashes, and only a simple declarative text file is required to launch a full experimental campaign for all required models. Its modular structure allows users to implement their own plugins and model-building wrappers and easily add them to the library. We test aMLLibrary on building the performance models of neural networks and image processing applications, with the best model produced often having less than 20% prediction error.
Implementation And Evaluation Of An Arthroscopic Tracker System For Intraoperative Motion Tracking And Force Registration
Authors: Bjelland Oystein , Hatledal Lars Ivar , Bye Robin T. , Steinert Martin
Published: August 2023

This paper presents implementation and evaluation of an intraoperative arthroscopic tracker system for research and educational use. The system enables automatic pose and force data exchange between a physical asset and a digital model, which is required in arthroscopic digital twins. Surgical instrument motion tracking is captured using an inertial measurement unit in combination with stereo vision (ZED mini, Stereolabs, USA), and force registration is achieved using a 6 degree-of-freedom force-torque sensor (Nano 25, ATI Industrial Automation, USA). An integration layer in the software system continuously fetches data from the sensors, and transmits data over a network connection. The software visualization layer displays the instrument pose and force readings relative to a 3D anatomical model in real-time (24 Hz). Position accuracy of the system was compared to a Kuka LBR Med 14 R820 collaborative robot, and the total root mean square error was found to be 12.60 mm. A post-operative instrument trajectory map from sampled pose and force/torque data was implemented in Matlab, and demonstrated in an experiment. The system is feasible for use in many research and educational applications.
Anomaly Detection In TCP/IP Networks
Authors: Kolodziej Joanna , Krzyszton Mateusz , Szynkiewicz Pawel
Published: August 2023

Intrusion Detection Systems (IDS) should be capable of quickly detecting attacks and network traffic anomalies to reduce the damage to the network components. They may efficiently detect threats based on prior knowledge of attack characteristics and the potential threat impact ('known attacks'). However, IDS cannot recognize threats, and attacks ('unknown attacks') usually occur when using brand-new technologies for system damage. This paper presents two security services -- Net Anomaly Detector (NAD) and a signature-based PGA Filter for detecting attacks and anomalies in TCP/IP networks. Both services are modules of the cloud-based GUARD platform developed in the H2020 GUARD project. Such a platform was the main component of the simulation environment in the work presented in this paper. The provided experiments show that both modules achieved satisfactory results in detecting an unknown type of DoS attacks and signatures of DDoS attacks.
Post-percutaneous core needle biopsy sputum cytology: diagnostic value and factors for positive prediction in diagnosing malignancy
Authors: Lee Sang Kyu , Kang Hee , Jung Min Jung , Park Sekyoung , Lee Ki Nam
Published: August 2023

Background: This study evaluated the diagnostic yield and positive predictive factors of post-percutaneous core needle biopsy (PCNB) sputum cytology in diagnosing malignancy.Methods: This retrospective study included patients who underwent PCNB at a single center from January 2014 to March 2022. Patient demographics, lung lesion characteristics on computed tomography, underlying lung disease, post-PCNB complications, histopathologic results of PCNB, post-PCNB sputum specimens, and final diagnoses were reviewed. The diagnostic yields and related factors were analyzed.Results: Overall, 177 consecutive patients with sputum specimens obtained after PCNB for intrapulmonary lesions were enrolled. Among them, 152 patients had a final diagnosis of malignancy. Diagnostic sputum specimens with atypical or malignant cells were obtained in 12 patients. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of sputum cytology were 7.89%, 100%, 20.90%, 100%, and 15.15%, respectively. Lesion size, air-bronchogram, lesion multiplicity, and the cell type of squamous cell and adenocarcinoma differed significantly between the groups with diagnostic versus non-diagnostic sputum (p<0.05). The lesion size (odds ratio [OR], 1.035; 95% confidence interval [CI], 1.008–1.064; p=0.013), presence of air-bronchogram (OR, 23.485; 95% CI, 2.532–217.316; p=0.005), and squamous cell carcinoma (OR, 7.397; 95% CI, 1.773–30.865; p=0.006) were significantly associated with a diagnostic sputum specimen post-PCNB.Conclusions: Although post-PCNB sputum cytology had low sensitivity in diagnosing lung cancer, it showed diagnostic results in some peripheral lung cancer patients who have squamous cell types, relatively large tumors, and air-bronchograms in the lesions.
The Sound of Silence: Saint Cecilia and Celestial Music in Hart Crane
and Stéphane Mallarmé
Authors: Piechucka Alicja
Published: August 2023

The article examines Hart Crane’s and Stéphane Mallarmé’s approaches to music as exemplified by two poems: the former’s “Sonnet” and the latter’s “Saint.” Linked by the figure of Saint Cecilia, the patroness of music, the two works do more than just explore similar motifs. In fact, both are aesthetic statements on the role of music in verse, on the poet’s predicament and on a certain concept of poetry rooted in the symbolist-modernist continuum, of which Crane’s oeuvre is an example. My analysis takes into account Boethius’s and Kepler’s theories of music, Platonism, with which symbolist poetry is inextricably linked, the concept of pure poetry and the notion of the music of the spheres, central to both poems.
NAD+ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages
Authors: Iske Jasper , El Fatimy Rachid , Nian Yeqi , Ghouzlani Amina , Eskandari Siawosh K , Cetina Biefer Hector Rodriguez , Vasudevan Anju , Elkhal Abdallah
Published: August 2023

Septic shock is characterized by an excessive inflammatory response depicted in a cytokine storm that results from invasive bacterial, fungi, protozoa, and viral infections. Non-canonical inflammasome activation is crucial in the development of septic shock promoting pyroptosis and proinflammatory cytokine production via caspase-11 and gasdermin D (GSDMD). Here, we show that NAD+ treatment protected mice toward bacterial and lipopolysaccharide (LPS)-induced endotoxic shock by blocking the non-canonical inflammasome specifically. NAD+ administration impeded systemic IL-1β and IL-18 production and GSDMD-mediated pyroptosis of macrophages via the IFN-β/STAT-1 signaling machinery. More importantly, NAD+ administration not only improved casp-11 KO (knockout) survival but rendered wild type (WT) mice completely resistant to septic shock via the IL-10 signaling pathway that was independent from the non-canonical inflammasome. Here, we delineated a two-sided effect of NAD+ blocking septic shock through a specific inhibition of the non-canonical inflammasome and promoting immune homeostasis via IL-10, underscoring its unique therapeutic potential.
A utilização do Modelo de Beneish como ferramenta complementar na mitigação dos riscos de fraudes contábeis pela governança coorporativa no mercado de capitais brasileiro
Authors: Bispo Ygor Santana , De Oliveira Jean Serrao
Published: August 2023

Diante do cenário corporativo de empresas de capital aberto, este estudo tem por objetivo central realizar uma analise sobre a utilização do Modelo de Beneish como ferramenta complementar na mitigação dos riscos de fraudes contábeis pela governança coorporativa das empresas, além de dar oportunidade ao mercado de detectar com antecedência a manipulação de resultados nos balanços disponibilizados por essas organizações. A metodologia aplicada para o desenvolvimento do artigo foi fundamentada pela natureza documental, abordagem quantitativa e com levantamento de dados para fins exploratórios e descritivos, através de artigos, Bolsa de valores (B3 - Bolsa, Brasil, Balcão) e pesquisa documental com ênfase em governança corporativa e no Modelo de Beneish. O estudo aborda casos de escândalos fraudulentos envolvendo grandes empresas ao longo dos anos e que se tornaram público no período de 2012 a 2021, apresentando relevância à literatura, e contribuindo com a identificação das possíveis melhorias que possam mitigar as fraudes das empresas de capital aberto, bem como a exploração da governança Corporativa nas empresas como possível filtro de irregularidades nas demonstrações contábeis. Além disso, a metodologia presente está baseada no trabalho de Beneish (1999). Para tanto, realizou-se um estudo descritivo nos dados das demonstrações contábeis de três empresas listadas na bolsa valores do brasil (B3), que já apresentaram fraudes, a seguir: CVC Brasil Operadora e Agência de Viagens, Petróleo Brasileiro S.A (Petrobras); Americanas S.A. Ao examinar casos reais de fraudes financeiras, analisamos como a utilização do método Beneish pode identificar sinais de alerta que indicam possíveis práticas fraudulentas.
Modelo pedagógico inclusivo para la enseñanza aprendizaje de la matemática a través de la resolución de problemas en niños de grado quinto con TDAH
Authors: Mesino Randy Zabaleta , Velásquez Osvaldo Rojas , Ramírez Miguel Cruz
Published: August 2023

Las instituciones educativas reportan cada vez más casos de fracaso escolar a causa del TDAH, así mismo los maestros carecen de estrategias suficientes para el acompañamiento de los estudiantes que les permitan mejorar su práctica pedagógica. En este trabajo tuvo como propósito presentar un modelo pedagógico TDR inclusivo, el cual está fundamentado en el modelo TRU de Schoenfeld, el diseño universal para el aprendizaje DUA y la resolución de problemas matemáticos, para favorecer la enseñanza aprendizaje de la matemática a través de la resolución de problemas en estudiantes de grado quinto de la básica primaria con diagnóstico por déficit de atención e hiperactividad TDAH. La metodología de investigación es cualitativa con un diseño de acción participativa. En los resultados se muestra la caracterización de los tres escenarios correspondientes a los subtipos del TDAH, en los cuales se declaran las estrategias pedagógicas y didácticas para el acompañamiento de los estudiantes, para desarrollar las habilidades en la resolución de problema a través de una evaluación formativa con el fortalecimiento de la Zona de desarrollo próximo (ZDP) de Vygotsky, para el logro y mejoramiento de la autonomía del estudiante con TDAH. El modelo pedagógico TDR inclusivo empodera al estudiante en la resolución de problemas matemáticos, independientemente del contexto escolar.
Websites corporativos educacionais das IES: impasses entre a posição empresarial e os impactos reais na educação ambiental
Authors: Marreiro Liana Siqueira do Nascimento , Moita Neto José Machado , Dos Santos Maria de Jesus
Published: August 2023

Este artigo examina a relação entre a posição das Instituições Privadas de Ensino Superior (IES) em Teresina-PI que oferecem o curso de Direito e os impactos na educação ambiental. O objetivo geral desse estudo é analisar a adequação dos sítios eletrônicos das (IES) com a Lei nº 9.394/1996, de Diretrizes e Bases da Educação Brasileira (LDB), quanto ao atendimento à responsabilidade socioambiental na comunicação realizada com os consumidores. A pesquisa caracteriza-se pela natureza qualitativa, quantitativa, bibliográfica e documental com base teórica proposta pela Análise do Discurso, segundo Fairclough e outros autores. A análise crítica dos dados revelou que muitas Instituições pesquisadas não cumprem os requisitos mínimos exigidos pela lei, não expressam compromisso socioambiental e algumas vendem a educação como mercadoria, isso evidencia a negligência das questões ambientais e transforma o cidadão em mero cliente. Diante disso, o governo e a sociedade devem fiscalizar esses discursos corporativos para garantir a qualidade da educação e a responsabilidade ambiental.
O papel do profissional contábil na internacionalização de empresas
Authors: Casado Johny Henrique Magalhães , Sellitto Miguel Afonso
Published: August 2023

Este ensaio teórico tem como objetivo realizar uma revisão de literatura sobre o papel do profissional contábil no processo de internacionalização das empresas. Com o crescente interesse das organizações em buscar novos mercados e fornecedores internacionais, compreender a atuação do contador nessa temática é fundamental, visto que sua presença é essencial para operacionalizar atividades no mercado nacional. O estudo foi realizado a partir de um levantamento de 137 artigos publicados sobre a temática que tenham sido publicados em vários periódicos. Assim, como conclusão, percebeu-se que quando as empresas estão conduzindo as operações internacionais, outros profissionais acabam ganhando maior destaque em detrimento dos profissionais da contabilidade.
A nucleação de alunos no transporte escolar
Authors: Kloeckner Natalia Varela da Rocha
Published: August 2023

A gestão do transporte escolar possui considerada relevância para o alcance da educação às diferentes esferas da sociedade, uma vez que representa para alguns alunos o único meio de acesso e permanência no ambiente escolar. Programas governamentais como o Programa Nacional de Transporte Escolar, visa à contribuição financeira para aquisição de ônibus para os municípios. Contudo, a medida não representa uma solução em si mesma, pois antes de se ofertar o serviço, há a necessidade de rotear o percurso que o ônibus deve fazer a fim de atender satisfatoriamente a todos os alunos demandantes. Isso reflete diretamente no desempenho dos resultados econômicos, operacionais e sociais das instituições envolvidas. Nesse estudo, aborda-se o problema de Nucleação de Alunos no Transporte Escolar, que consiste em alocar cada aluno, em sua respectiva série, na escola mais próxima possível de sua residência, considerando a capacidade que cada série possui para atendimento da demanda. Logo, trata-se de otimizar os agrupamentos formados de tal modo a reduzir o percurso de translado do aluno para a escola, o que resulta em uma otimização de tempo, redução do custo da viagem, melhor bem-estar do aluno e incremento do processo de aprendizagem. Logo, o objetivo desse trabalho consiste em desenvolver um modelo matemático para agrupar os alunos, por série, em cada escola. A formulação proposta foi aplicada em um estudo de caso na cidade de Maranguape, no Estado do Ceará, apresentando resultados consistentes.
Natural language requirements boilerplates: an integrative literature review
Authors: Barbosa Leonardo de Mello , Cerqueira Christopher Shneider , Da Cunha Antonio Eduardo Carrilho
Published: August 2023

In the field of Requirements Engineering, natural language is the most widely used form of documenting systems requirements, mainly for its expressiveness power, freedom of words, and easiness of use. On the other hand, written requirements are frequently ambiguous, incomplete, and incorrect, among other defects, impacting into the system lifecycle. To mitigate this issue, researchers have, since 1998, developed dozens of sets of boilerplates, aiding to guide natural language requirements composition. In this integrative literature review, authors searched for these sets in traditional academic databases, grey literature, and professional media, leading to a list of 54 relevant documents. Analysis of these primary works revealed that, even when boilerplate creators wish their artifacts to be used on all kinds of systems, they are generally cataloged under the Computer Science umbrella. It turned out to be evident that ambiguity is the main issue of quality of requirements addressed by boilerplates, followed by completeness and consistency. Authors mapped the requirements boilerplates definition modes, concluding that plain sentences are the foremost choice to describe these creations. It is claimed that systematization on the construction and evaluation of requirements boilerplates is still a problem to render these activities repeatable and reproducible, as the largest part of documents does not report it. Finally, the reported evaluation methods were hierarchically clustered, leading to three typical approaches for this activity.
Genetic and Kinetic Profiles of Bacterial Resistance Enzymes to IMP and NDM Type Antibiotics in Gram-negative Pathogenic Bacilli
Authors: Bambara Lionel Eliada Benoit , Dabire Amana Metuor , Traore Oumar , Tiemtore Yasmine , Zohoncon Theodora , Simpore Jacques
Published: August 2023

Introduction: Enterobacteria are among the most frequent isolated strains in hospitalized patients. Currently, carbapenems have a broad spectrum of activity and are considered to be the last resort for the treatment of nosocomial infections. However, overuse of these valuable compounds has led to a rapid increase in antimicrobial resistance. The aim was to study the genetic and kinetic profiles of IMP and NDM bacterial resistance enzymes in Gram-negative pathogenic bacilli.

Methodology: The carbapenems used for strain susceptibility testing consisted of Ertapenem, Meropenem, Imipenem and Doripenem. Detection of the IMP and NDM resistance genes encoding carbapenemases was carried out by conventional PCR at LABIOGENE, and hydrolysis of the enzymatic crude extracts was performed.

Results: Strains showed high levels of resistance to Ertapenem (64%), Meropenem (41%), Imipenem (53%) and Doripenem (73%). PCR amplification of carbapenem resistance genes showed that 32% of strains carried blaIMP, 16% of strains carried blaNDM. Both blaIMP & blaNDM were identified with a prevalence of 6.76%. Escherichia coli was the majority species harboring these genes. The kinetic constants of NDM carried by E. coli are Km=333µM and Vmax=0.5 A/min. Those of IMP carried by Klebsiella sp are Km=500µM and Vmax=0.6 A/min.

Conclusion: This study enabled us to determine the rate of carbapenem resistance in Gram-negative bacteria. We noticed that Meropenem was the most active molecule. The study also enabled us to determine the affinity of two different bacterial enzymes to nitrocefin.
Lavender: A Magical Herb with Medicinal Properties
Authors: R. Atchaya  , Thaneshwari  , Prakash Keerthi
Published: August 2023

Every year about 3/4th of the world’s population is suffering from insomnia and is the major reason for many health illness leading to mortality. Insomnia is also an economic burden to the people in both the direct and indirect ways. The general treatment of insomnia includes the powerful drugs and sleeping pills, which cause some side implications in human health and these treatments are also very costly. This review aims to highlight the effects of insomnia and treatment of insomnia by alternate ways i.e) non-medical ways, with additional effects to the human health and economically acceptable by all the classes of people.
Microbiology and Physicochemical Characteristics of Surface Water from a Local Refinery Site in Port Harcourt, Nigeria
Authors: Mebom Chibuike, Princess , Olufunmilayo Williams, Janet , Queen Ajah, Elizabeth
Published: August 2023

Water plays a vital role in maintaining human health but due to an increase in industrialization, urbanization and other anthropogenic activities, surface water pollution is on an increase. This research was carried out to investigate the microbiological and physicochemical status of a crude oil polluted surface water in Iwofe River, Rumuolemini, Port Harcourt. Samples were collected from two points (Upstream and Downstream) bi-monthly for a period of three months. The THB counts for the upstream and downstream samples were 1.7 × 108cfu/ml and 1.4 × 108 cfu/ml, respectively while the THF counts for the samples were 3.0 × 106cfu/ml and 1.4 × 106 cfu/ml, respectively. Hydrocarbon utilizing bacterial (HUB) counts were higher in the upstream (1.5 × 106cfu/ml) than downstream (4.3 ×105cfu/ml) location of the Iwofe River. The Hydrocarbon utilizing fungal (HUF) count ranged from 1.0 × 105cfu/ml to 1.4 × 105 cfu/ml in the upstream and downstream water samples, respectively. The results of all the microbiological parameters analyzed indicated that the total heterotrophic bacterial (THB) and Total heterotrophic fungal (THF) counts were higher in the upstream than in the downstream location. The Most Probable Number (MPN) method used for the determination of coliform counts revealed the presence of coliforms both upstream and downstream, with an MPN index of 1,600/100ml of each sample. Some of the bacterial species isolated were Staphylococcus aureus, Escherichia coli and Vibrio cholerae while the fungal isolates included Aspergillus fumigatus, Penicillium species and Alternaria species. The high level of oil contamination poses a great health threat and there is a need for remediation of the aquatic ecosystem.
The Lived Experiences of Preschool Children Ages 3–4: The Practices of Independence in the Case Some Pre School in Vietnam
Authors: Nguyen Nhung Thi
Published: August 2023

Independence helps children to always be confident and to control themselves in activities and communication. Education for independence is an urgent issue for education systems around the world to meet the requirements of society in the current context, one side it represented the developments of the education system and the other is it shows the developments of the early ages of the generation of a nation. By means of observation measured by the 5-point Likert scale, by the observers are lecturers and staff of the National College for Education this study was conducted in suburban and inner-city schools of both public and non-public types on the independence of 3–4-year-olds whose ages from 36 to 48 months the data then was collected and proceed by SPSS. The results show that children's independence is quite good, with a five-point scale in all independent expressions. However, there is a need for more in-depth additional studies for each type of school or further identification of the influencing factors for children's independence at this age.
Temporal Trends in the Use of Systemic Medications for Acne From 2017 to 2020
Authors: Barbieri John S.
Published: August 2023

This cross-sectional study uses data from the Truven MarketScan Commercial Claims Database for 2017 through 2020 to assess prescribing patterns for systemic acne treatments.
3D Printing by Two‐Photon Polymerization of Polyimide Objects and Demonstration of a 3D‐printed Micro‐Hotplate
Authors: Pagliano Simone , Schröder Stephan , Stemme Göran , Niklaus Frank
Published: August 2023

Polyimides are polymeric materials with outstanding thermal, chemical, and mechanical properties. For this reason, they find applications in several engineering sectors, including aerospace, microsystems, and biomedical applications. For realizing 3D structures made of polyimides, 3D printing is an attractive technique because it overcomes the limitations of polyimide processing using conventional manufacturing techniques such as molding and subtractive manufacturing. However, current polyimide 3D printing approaches are limited to realizing objects with the smallest dimensions of the order of a few hundred micrometers. 3D printing of polyimide objects featuring sub‐micrometer resolution using two‐photon polymerization by direct laser writing is demonstrated here. A negative photosensitive polyimide is applied that is widely used in microsystems applications. To demonstrate the utility of this polyimide 3D printing approach and the compatibility of the 3D objects with operation at elevated temperatures, a micro‐hotplate is 3D printed and characterized at operating temperatures of above 300 °C.
Survivin‐Based Recombinant Overlapping Peptides Induce T Lymphocyte Cytotoxicity and Prolong the Survival in In Vivo Melanoma Model
Authors: Zhang Yuanting , Zhou Yihan , Gong Min , Zhang Qing , Zheng Qiujie , Shen Yuanying , Lu Wenshu , Jiang Shisong
Published: August 2023

Anti‐cancer vaccination emerged as a promising and cost‐effective immunotherapy, but the lack of immunogenicity has hindered the success of therapeutic vaccine development. To address this issue and improve therapeutic efficacy, this study presents the examination of recombinant overlapping peptides (ROP) based on the tumor‐associated antigen, survivin, on in vivo immunogenicity and anti‐tumor efficacy using a melanoma C57/BL mouse model. Results show that ROPs induce a remarkable 46.5% cytotoxic activity mediated by activated cytotoxic T lymphocytes, compared to only 3% in wild‐type (WT) survivin protein. Additionally, ROPs significantly reduce tumor size by over 500 mm3 and prolong survival rates in mice with zero deaths in the first 17 days and 30% survival at the end of day 23, while no mice immunized with WT survivin protein survive beyond day 20. ROPs combined with anti‐4‐1BB agonists lead to additional tumor size reduction by 500 mm3 and 70% survival on day 23. These findings underscore the importance of survivin as a trigger for tumor‐restricting immunity and provide therapeutic evidence of ROPs' anti‐tumor potential, especially when combined with other immunostimulants, such as anti‐4‐1BB agonists. ROPs and adjuvant immunostimulants represent a potent vaccine strategy for therapeutic purposes, increasing vaccine immunogenicity and improving survival against cancer.
Ultrafast Detection of Monoamine Oxidase A in Live Cells and Clinical Glioma Tissues Using an Affinity Binding‐Based Two‐Photon Fluorogenic Probe
Authors: Zhang Congcong , Fang Haixiao , Du Wei , Zhang Duoteng , Qu Yunwei , Tang Fang , Ding Aixiang , Huang Kai , Peng Bo , Li Lin , Huang Wei
Published: August 2023

Abnormal expression of monoamine oxidase A (MAO−A) has been implicated in the development of human glioma, making MAO−A a promising target for therapy. Therefore, a rapid determination of MAO−A is critical for diagnosis. Through in silico screening of two‐photon fluorophores, we discovered that a derivative of N,N‐dimethyl‐naphthalenamine (pre‐mito) can effectively fit into the entrance of the MAO−A cavity. Substitutions on the N‐pyridine not only further explore the MAO−A cavity, but also enable mitochondrial targeting ability. The aminopropyl substituted molecule, CD1, showed the fastest MAO−A detection (within 20 s), high MAO−A affinity and selectivity. It was also used for in situ imaging of MAO−A in living cells, enabling a comparison of the MAO−A content in human glioma and paracancerous tissues. Our results demonstrate that optimizing the affinity binding‐based fluorogenic probes significantly improves their detection rate, providing a general approach for rapid detection probe design and optimization.
Gas foaming of polyphenyl sulfone: Effect of the blowing agents and operating parameters
Authors: Trucillo Paolo , Errichiello Fabrizio , Di Maio Ernesto
Published: August 2023

Polyphenyl sulfone (PPSU) is a highly stable and rigid polymer with good chemical and mechanical resistance used in automotive and aerospace industries in high‐temperature applications during long‐operating cycles. PPSU foams are applied as core materials in lightweight composites ensuring high strength, fire resistance, thermal and acoustic insulation. In this paper, PPSU slabs are foamed using CO2, N2, and He as blowing agents (BAs). An experimental campaign is carried out to estimate the BAs' diffusivity in the polymer. In details, CO2 diffusivity ranges from 8E‐11 to 1E‐09 m2/s at temperatures from 220 to 260°C; diffusivity of N2 ranges from 2E‐10 to 5E‐09 m2/s (220–260°C) and it is 4E‐09 m2/s for He at 220°C. Foaming tests reveal an expansion ratio as high as 400% for CO2, 130% for He, and 150% for N2.Scanning electron microscopy analysis is also performed on produced samples, obtaining a cell number density of 1.3E07, 2.6E05, and 1.8E06 cells/cm3 when saturating, respectively, with CO2 at 220°C and 100 bar, N2 at 220°C and 100 bar, and He at 230°C and 100 bar.
Iminoboranes With Parent B=NH Entity: Imino Group Metathesis, Nucleophilic Reactivity and N−N Coupling
Authors: Dolati Hadi , Denker Lars , Martínez Juan Pablo , Trzaskowski Bartosz , Frank René
Published: August 2023

While R2C=N−R double bonds in organic imines are well established, the related iminoboranes R‐B=N−R are either prone to oligomerization or can only be stabilized at sufficient steric congestion. In particular, the examples of unsubstituted parent B=N‐H entity are rare. We demonstrate that the amino imidazoline‐2‐imine ligand system (HAmIm) not only gives rise to the isolation of a parent (AmIm)B=N−H iminoborane, but also to species of type (AmIm)B=N‐SiMe3 with concomitant stabilization by lithium bromide. The double bond character in these systems is unambiguously corroborated by DFT calculations. The steric accessibility of the (AmIm)B=NH unit allows facile reactivity including metathesis reactions with C=O and C=S bonds, nucleophilic addition toward organic and organometallic carbonyl compounds, but also oxidative N−N coupling within a dimeric unit. Thus, the chemical behavior of the (AmIm)B=N−H and (AmIm)B=N‐SiMe3 is distinctly different from that of organic imines.
Magnetic, Dielectric, and Thermal Properties of BaCo‐Hexaferrite Nanospheres
Authors: Ramanjaneyulu O. , Kumar N. Suresh , Basha D. Baba , Naidu K. Chandra Babu
Published: August 2023

BaxCo1‐xFe12O19 (x = 0.2, 0.4, 0.6, & 0.8) nanoparticles are prepared via hydrothermal method. The hexagonal structure of x = 0.2 – 0.8 samples is confirmed by X‐ray diffraction patterns. Morphology indicated the existence of nanospheres like grains. The magnetic and dielectric parameters are clearly discussed as a function of composition at room temperature. The increase of Ba‐content reduced the magnetization from 56.1 to 49.7 emu g−1, and at higher Ba‐content, it is increased from 49.7 to 57.3 emu g−1. The x = 0.6 content offered the high ε' ≈9.54 and low ε" ≈0.12 values suitable for charge storage, and low noise device applications. Further, the thermal properties (using thermogravimetry (TG)‐differential thermogravimetry (DTG) & TG‐differential scanning calorimetry (DSC)) are elucidated in detail.
Mechanochemical Synthesis of Corannulene: Scalable and Efficient Preparation of A Curved Polycyclic Aromatic Hydrocarbon under Ball Milling Conditions
Authors: Báti Gábor , Laxmi Shoba , Stuparu Mihaiela C.
Published: August 2023

Corannulene, a curved polycyclic aromatic hydrocarbon, is prepared in a multigram scale through mechanochemical synthesis. Initially, a mixer mill approach is examined and found to be suitable for a gram scale synthesis. For larger scales, planetary mills are used. For instance, 15 g of corannulene could be obtained in a single milling cycle with an isolated yield of 90 %. The yields are lower when the jar rotation rate is lower or higher than 400 revolutions per minute (rpm). Cumulatively, 98 g of corannulene is produced through the ball milling‐based grinding techniques. These results indicate the future potential of mechanochemistry in the rational chemical synthesis of highly curved nanocarbons such as fullerenes and carbon nanotubes.
Toward a deep CNN and RS‐GOA framework for vehicle detection, traffic flow estimation, and optimal path selection from surveillance videos
Authors: Sasikala S. , Neelaveni R. , Jose P. Sweety
Published: August 2023

Several autonomous traffic monitoring systems have been created as a result of the growing number of vehicles in urban areas. Traffic surveillance systems that use roadside cameras, in particular, are becoming widely used for traffic management. For an efficient traffic control and vehicle navigation system, accurate traffic flow information must be obtained based on the vehicles detected in surveillance videos. However, vehicles of various scales are difficult to spot in traffic surveillance videos due to the presence of barricades, other vehicles, and the impact of poor lighting. Also, adverse weather conditions like snow, fog, and heavy rain diminish the visual quality of the surveillance footage. This paper proposes multi‐scale dense nested deep CNN (MSDN‐DCNN) and regional search grasshopper optimization algorithm (RS‐GOA) framework to accurately detect the vehicles, estimate the traffic flow, and find the optimal path with less travel time. First, the surveillance videos are pre‐processed, which includes frame conversion, redundancy removal, and image enhancement. The pre‐processed frames are given as input to the MSDN‐DCNN for multi‐scale vehicle detection. The detected results are used for vehicle counting and estimating the traffic flow. Finally, the optimal path is chosen based on the traffic flow information by using the RS‐GOA algorithm. The performance of the proposed method is compared with the existing vehicle detection and path selection techniques. The results illustrate that the proposed Deep CNN‐RS‐GOA framework has improved performance with high detection accuracy (91.03%), high speed (53.9 fps), less running time (1,000 ms), less travel time, and faster convergence.
A protected flow breaks the drought for golden perch (Macquaria ambigua) spawning along an extensive semi‐arid river system
Authors: Thiem Jason D. , Michie Laura E. , Butler Gavin L. , Ebner Brendan C. , Sharpe Clayton P. , Stuart Ivor , Townsend Anthony
Published: August 2023

Freshwater ecosystems are under extreme stress due to anthropogenic influences including changing climate, river regulation and water abstraction. Improving our understanding of the hydrological determinants of key life‐history processes of fish, as well as the spatial scales over which these processes occur, is fundamental to inform effective recovery actions. We monitored the spawning response of native fish to a drought‐breaking long‐distance flow pulse that was protected from extraction by a legal intervention order in Australia's northern Murray–Darling Basin. Sampling sites were distributed across >1600 km of the Barwon–Darling River and three of its major tributaries. Larvae of the pelagophilic golden perch (Macquaria ambigua) were captured at all sites, with the size and age distribution indicative of both mainstem and tributary spawning. A mismatch between estimated hatch dates and river discharge at some locations suggested substantial flow‐assisted dispersal from upstream spawning sites, although this was site‐specific and more prevalent at downstream locations. Early life growth rates were the highest at tributary sites compared with mainstem sites, and within mainstem sites, golden perch grew faster in upper reaches compared with lower reaches. The present study provides insight into the environmental benefit of a post‐drought protected flow event whereby connected lotic habitats promoted fish spawning and dispersal over a large spatial scale. Protection of future flow events should occur to support the conservation of golden perch and other pelagophil species, particularly following future drought periods which are forecast to become more intense and frequent.
Radical Dearomatising Spirocyclisation of Benzisoxazole‐Tethered Ynones
Authors: Inprung Nantachai , Whitwood Adrian C. , Taylor Richard J. K. , James Michael J. , Unsworth William P.
Published: August 2023

The dearomative spirocyclisation of benzisoxazoles through a radical chain mechanism is described. Densely functionalised spirocycles were prepared in high yields by reacting benzisoxazole‐tethered ynones with aryl thiols in 1,2‐dichloroethane (DCE) at 60 °C. The identification of stabilising three‐electron interactions was key to the development of this new radical cascade reaction. The obtained spirocyclic products were converted into other spirocyclic scaffolds through a two‐step hydrogenolysis‐cyclisation sequence.
Modified‐Hydroxyapatite‐Chitosan Hybrid Composite Interfacial Coating on 3D Polymeric Scaffolds for Bone Tissue Engineering
Authors: Poddar Deepak , Singh Ankita , Rao Pranshu , Mohanty Sujata , Jain Purnima
Published: August 2023

Three dimensional (3D) scaffolds have huge limitations due to their low porosity, mechanical strength, and lack of direct cell‐bioactive drug contact. Whereas bisphosphonate drug has the ability to stimulate osteogenesis in osteoblasts and bone marrow mesenchymal stem cells (hMSC) which attracted its therapeutic use. However it is hard administration low bioavailability, and lack of site‐specificity, limiting its usage. The proposed scaffold architecture allows cells to access the bioactive surface at their apex by interacting at the scaffold's interfacial layer. The interface of 3D polycaprolactone (PCL) scaffolds has been coated with alendronate‐modified hydroxyapatite (MALD) enclosed in a chitosan matrix, to mimic the native environment and stupulate the through interaction of cells to bioactive layer. Where the mechanical strength will be provided by the skeleton of PCL. In the MALD composite's hydroxyapatite (HAP) component will govern alendronate (ALD) release behavior, and HAP presence will drive the increase in local calcium ion concentration increases hMSC proliferation and differentiation. In results, MALD show release of 86.28 ± 0.22. XPS and SEM investigation of the scaffold structure, shows inspiring particle deposition with chitosan over the interface. All scaffolds enhanced cell adhesion, proliferation, and osteocyte differentiation for over a week without in vitro cell toxicity with 3.03 ± 0.2 kPa mechanical strength.
Prevention of Falls in Parkinson's Disease: Guidelines and Gaps
Authors: Camicioli Richard , Morris Meg E. , Pieruccini‐Faria Frederico , Montero‐Odasso Manuel , Son Surim , Buzaglo David , Hausdorff Jeffrey M. , Nieuwboer Alice
Published: August 2023

Background

People living with Parkinson's disease (PD) have a high risk for falls.

Objective

To examine gaps in falls prevention targeting people with PD as part of the Task Force on Global Guidelines for Falls in Older Adults.

Methods

A Delphi consensus process was used to identify specific recommendations for falls in PD. The current narrative review was conducted as educational background with a view to identifying gaps in fall prevention.

Results

A recent Cochrane review recommended exercises and structured physical activities for PD; however, the types of exercises and activities to recommend and PD subgroups likely to benefit require further consideration. Freezing of gait, reduced gait speed, and a prior history of falls are risk factors for falls in PD and should be incorporated in assessments to identify fall risk and target interventions. Multimodal and multi‐domain fall prevention interventions may be beneficial. With advanced or complex PD, balance and strength training should be administered under supervision. Medications, particularly cholinesterase inhibitors, show promise for falls prevention. Identifying how to engage people with PD, their families, and health professionals in falls education and implementation remains a challenge. Barriers to the prevention of falls occur at individual, environmental, policy, and health system levels.

Conclusion

Effective mitigation of fall risk requires specific targeting and strategies to reduce this debilitating and common problem in PD. While exercise is recommended, the types and modalities of exercise and how to combine them as interventions for different PD subgroups (cognitive impairment, freezing, advanced disease) need further study.
Inverse nodal problems for Sturm–Liouville operators on quantum star graphs
Authors: Oviedo Martina , Pinasco Juan Pablo
Published: August 2023

In this work, we study the nodal inverse problem for Sturm–Liouville operators on quantum star graphs. We show that the zeros of eigenfunctions characterize the potential, and we present a simple algorithm that enables us to approximate it. The method does not rely on a priori information about the asymptotic behavior of eigenvalues. We manage to reduce the problem to a family of constant coefficient eigenvalue problems that can be solved explicitly and contain enough information to recover the potential. We also consider the multiplicity of eigenvalues and their vanishing properties, which only hold generically.
Ground state solutions for a class of generalized quasilinear Schrödinger‐Maxwell system with critical growth
Authors: Zhang Shulin , Liu Wenbin
Published: August 2023

In this paper, we consider the following generalized quasilinear Schrödinger‐Maxwell system

Under suitable conditions on
,
, and
, we obtain the existence of ground state solutions with critical growth. To some extent, our results improve and supplement some existing relevant results.
Complete stealthiness false data injection attack design in multisensor systems with attack resource constraints
Authors: Qian Yi‐Hao , Li Xiao‐Jian , Sun Jie
Published: August 2023

This article is concerned with the attack design problem of multisensor cyber‐physical systems. Compared with the existing results developed for the single‐sensor system, the attacker is limited to modify partial sensors. To avoid generating alarm for the given detect mechanism, the correlation influence between the attacked and normal sensors is eliminated in the designed stealthiness condition. Then the trace of error covariance is used to measure the attack effect and the coupling information between sensors is also involved. By using the design freedom of stealthiness condition, the detailed attack parameters design and attacked channels selection strategy are derived to achieve the optimal attack performance via a two‐stage method including backstepping and eigenvalue sorting techniques. Finally, numerical simulation examples are provided to verify the effectiveness and advantages of the proposed attack method.