bluuebunny/crossref_metadata_2025 huggingface dataset:
Equation of State, Compressibility, and Vibrational Properties of Brucite over Wide Pressure and Temperature Ranges: Atomistic Computer Simulations with the Modified ClayFF Classical Force Field
Authors: Tararushkin Evgeny V. , Pisarev Vasily V. , Kalinichev Andrey G.
Published: March 2023

The behavior of brucite over wide ranges of temperatures and pressures is of great interest for fundamental geochemistry and geophysics. Brucite layers and their octahedral Mg(OH)6 structural units constitute an important structural part of layered dense magnesium hydrous silicates (DMHS), which play a major role in mineral equilibria controlling water balance in the subduction zones of the upper mantle. The ClayFF force field was originally developed for atomistic computer simulations of clays and other layered minerals and their hydrated interfaces. The crystallographic parameters of brucite at 25 °C and 1 bar were used, among several others, to develop the original ClayFF parametrization. Its new recent modification, ClayFF-MOH, can more accurately account for the bending of Mg–O–H angles in the brucite structure, and it was used here to test the applicability of this simple classical model over very wide ranges of temperature and pressure well beyond the range of its original implementation (up to 600 °C and 15 GPa). The pressure and temperature dependencies of brucite crystallographic parameters, the compressibility of the crystal lattice, the coefficients of thermal expansion, and the vibrational spectra were calculated in a series of classical molecular dynamics simulations using the ClayFF-MOH model and compared with a diverse set of available experimental data, including X-ray diffractometry, neutron scattering, IR and Raman spectroscopy. These new results demonstrated that ClayFF-MOH, as simple and approximate as it is, can be quite accurate in predicting many mineral properties at subduction zone conditions, which greatly expands the area of its applicability.
Study on Stability Control Mechanism of Deep Soft Rock Roadway and Active Support Technology of Bolt-Grouting Flexible Bolt
Authors: Zhang Hao , Li Yingming , Wang Xiangjun , Yu Shoudong , Wang Yi
Published: March 2023

In order to study the stability control mechanism of deep soft rock roadway and the active support technology of the anchor-grouting flexible bolt, this paper takes the west wing transportation roadway of Yuandian No. 2 Coal Mine of Huaibei Mining Co., Ltd., Huaibei, China as the research background. By analyzing the occurrence conditions and failure characteristics of the surrounding rock of the west wing transportation roadway and the structural characteristics and mechanical properties of the anchor-grouting flexible bolt, combined with the elastic–plastic and superimposed arch theory analysis, the superposition community theoretical model and the superposition joint support scheme of “bolt (cable) + anchor net + anchor-grouting flexible bolt + shotcrete support” are proposed. The reliability of the combined support scheme is analyzed by FLAC 3D numerical simulation software and field experiment. The results show that the maximum roof-to-floor convergence and two-side convergence of the west wing transportation roadway are only 30.7 mm and 27.1 mm after adopting the combined support scheme, and the deep displacement variation is within 7 mm, which can effectively maintain the stability of the roadway. The combined support scheme has a certain reference value for other similar roadways.
On Limits to Flotation Cell Size
Authors: Finch James A. , Tan Yue Hua
Published: March 2023

Mechanical cells have seen an exponential increase in size over the past 60 years. However, a possible size limitation due to carrying capacity constraints has been raised. Taking a Cu porphyry case, a cell sizing exercise is used to show that possible size limitation due to carrying capacity can be tested using available techniques. A range of conditions is explored that suggest a continued increase above the current maximum cell size, ca. 600 m3, does not seem warranted.
Influence of the Nature of Aminoalcohol on ZnO Films Formed by Sol-Gel Methods
Authors: Vilà Anna , Gómez-Núñez Alberto , Alcobé Xavier , Palacios Sergi , Puig Walz Teo , López Concepción
Published: March 2023

Here we present comparative studies of: (i) the formation of ZnO thin films via the sol-gel method using zinc acetate dihydrate (ZAD), 2-methoxyethanol (ME) as solvent, and the aminoalcohols (AA): ethanolamine, (S)-(+)-2-amino-1-propanol, (S)-(+)-2-amino-3-methyl-1-butanol, 2-aminophenol, and aminobenzyl alcohol, and (ii) elemental analyses, infrared spectroscopy, X-ray diffraction, scanning electron microscopy, absorption and emission spectra of films obtained after deposition by drop coating on glass surface, and thermal treatments at 300, 400, 500 and 600 °C. The results obtained provide conclusive evidences of the influence of the AA used (aliphatic vs. aromatic) on the ink stability (prior to deposition), and on the composition, structures, morphologies, and properties of films after calcination, in particular, those due to the different substituents, H, Me, or iPr, and to the presence or the absence of a –CH2 unit. Aliphatic films, more stable and purer than aromatic ones, contained the ZnO wurtzite form for all annealing temperatures, while the cubic sphalerite (zinc-blende) form was also detected after using aromatic AAs. Films having frayed fibers or quartered layers or uniform yarns evolved to “neuron-like” patterns. UV and photoluminescence studies revealed that these AAs also affect the optical band gap, the structural defects, and photo-optical properties of the films.
COVID-19 Is a Confounder of Increased Candida Airway Colonisation
Authors: Froidefond Margaux , Sevestre Jacques , Chaudet Hervé , Ranque Stéphane
Published: March 2023

An increased incidence of invasive fungal infection was reported in SARS-CoV-2-infected patients hospitalised in the intensive care unit. However, the impact of COVID-19 on Candida airway colonisation has not yet been assessed. This study aimed to test the impact of several factors on Candida airway colonisation, including SARS-CoV-2 infection. We conducted a two-pronged monocentric retrospective study. First, we analysed the prevalence of positive yeast culture in respiratory samples obtained from 23 departments of the University Hospital of Marseille between 1 January 2018 and 31 March 2022. We then conducted a case-control study, comparing patients with documented Candida airway colonisation to two control groups. We observed an increase in the prevalence of yeast isolation over the study period. The case-control study included 300 patients. In the multivariate logistic regression, diabetes, mechanical ventilation, length of stay in the hospital, invasive fungal disease, and the use of antibacterials were independently associated with Candida airway colonisation. The association of SARS-CoV-2 infection with an increased risk of Candida airway colonisation is likely to be a consequence of confounding factors. Nevertheless, we found the length of stay in the hospital, mechanical ventilation, diabetes, and the use of antibacterials to be statistically significant independent risk factors of Candida airway colonisation.
Genetic Analyses of Seed Longevity in Capsicum annuum L. in Cold Storage Conditions
Authors: Arif Mian Abdur Rehman , Tripodi Pasquale , Waheed Muhammad Qandeel , Afzal Irfan , Pistrick Sibylle , Schütze Gudrun , Börner Andreas
Published: March 2023

Seed longevity is the most important trait in the genebank management system. No seed can remain infinitely viable. There are 1241 accessions of Capsicum annuum L. available at the German Federal ex situ genebank at IPK Gatersleben. C. annuum (Capsicum) is the most economically important species of the genus Capsicum. So far, there is no report that has addressed the genetic basis of seed longevity in Capsicum. Here, we convened a total of 1152 Capsicum accessions that were deposited in Gatersleben over forty years (from 1976 to 2017) and assessed their longevity by analyzing the standard germination percentage after 5–40 years of storage at −15/−18 °C. These data were used to determine the genetic causes of seed longevity, along with 23,462 single nucleotide polymorphism (SNP) markers covering all of the 12 Capsicum chromosomes. Using the association-mapping approach, we identified a total of 224 marker trait associations (MTAs) (34, 25, 31, 35, 39, 7, 21 and 32 MTAs after 5-, 10-, 15-, 20-, 25-, 30-, 35- and 40-year storage intervals) on all the Capsicum chromosomes. Several candidate genes were identified using the blast analysis of SNPs, and these candidate genes are discussed.
The Leaf Essential Oil of Gynoxys buxifolia (Kunth) Cass. (Asteraceae): A Good Source of Furanoeremophilane and Bakkenolide A
Authors: Cumbicus Carolina , Malagón Omar , Cumbicus Nixon , Gilardoni Gianluca
Published: March 2023

The present study describes the chemical and enantiomeric composition of a new essential oil, distilled from the dry leaves of Gynoxys buxifolia (Kunth) Cass. The chemical analysis was conducted by GC-MS and GC-FID, on two orthogonal capillary columns. A total of 72 compounds were detected and quantified with at least one column, corresponding to about 85% by weight of the whole oil mass. Of the 72 components, 70 were identified by comparing the respective linear retention indices and mass spectra with data from the literature, whereas the two main constituents were identified by preparative purification and NMR experiments. The quantitative analysis was carried out calculating the relative response factor of each compound according to their combustion enthalpy. The major constituents of the EO (≥3%) were: furanoeremophilane (31.3–28.3%), bakkenolide A (17.6–16.3%), caryophyllene oxide (6.0–5.8%), and (E)-β-caryophyllene (4.4%). Additionally, the hydrolate was also analyzed with respect to the dissolved organic phase. About 40.7–43.4 mg/100 mL of organic compounds was detected in solution, of which p-vinylguaiacol was the main component (25.4–29.9 mg/100 mL). Finally, the enantioselective analysis of some chiral terpenes was carried out, with a capillary column based on β-cyclodextrin chiral stationary phase. In this analysis, (1S,5S)-(−)-α-pinene, (1S,5S)-(−)-β-pinene, (S)-(+)-α-phellandrene, (S)-(+)-β-phellandrene, and (S)-(−)-terpinen-4-ol were detected as enantiomerically pure, whereas (S)-(−)-sabinene showed an enantiomeric excess of 69.2%. The essential oil described in the present study is a good source of two uncommon volatile compounds: furanoeremophilane and bakkenolide A. The former lacks bioactivity information and deserves further investigation, whereas the latter is a promising selective anticancer product.
Reduction in Nitrogen Rate and Improvement of Nitrogen Use Efficiency without Loss of Peanut Yield by Regional Mean Optimal Rate of Chemical Fertilizer Based on a Multi-Site Field Experiment in the North China Plain
Authors: Hu Jiayu , Yang Yang , Zhang Hongyan , Li Yuhao , Zhang Shuhong , He Xinhua , Huang Yufang , Ye Youliang , Zhao Yanan , Yan Jungying
Published: March 2023

It is important to quantify nutrient requirements and optimize fertilization to improve peanut yield and fertilizer use efficiency. In this study, a multi-site field trial was conducted from 2020 to 2021 in the North China Plain to estimate nitrogen (N), phosphorus (P), and potassium (K) uptake and requirements of peanuts, and to evaluate the effects of fertilization recommendations from the regional mean optimal rate (RMOR) on dry matter, pod yield, nutrient uptake, and fertilizer use efficiency. Results show that compared with farmer practice fertilization (FP), optimal fertilization (OPT) based on the RMOR increased peanut dry matter by 6.6% and pod yield by 10.9%. The average uptake rates of N, P, and K were 214.3, 23.3, and 78.4 kg/ha, respectively, with 76.0% N harvest index, 59.8% P harvest index, and 41.4% K harvest index. The OPT treatment increased N, P, and K uptake by 19.3%, 7.3%, and 11.0% compared with FP, respectively. However, the average of yield, nutrition uptake, and harvest indexes of N, P, and K were not significantly affected by fertilization. The peanut required 42.0 kg N, 4.6 kg P, and 15.3 kg K to produce 1000 kg of pods. The OPT treatment significantly improved the N partial factor productivity and N uptake efficiency but decreased the K partial factor productivity and K uptake efficiency. The present study demonstrates that fertilizer recommendations from RMOR improve N use efficiency, and reduce N and P fertilizer application without yield loss in regions with smallholder farmers, and the corresponding estimation of nutrient requirements helps to make peanut fertilization recommendations.
PEDOT Films Doped with Titanyl Oxalate as Chemiresistive and Colorimetric Dual-Mode Sensors for the Detection of Hydrogen Peroxide Vapor
Authors: Xie Xiaowen , Gao Nan , Hunter Matthew , Zhu Ling , Yang Xiaomei , Chen Shuai , Zang Ling
Published: March 2023

Hydrogen peroxide (H2O2) is commonly used as an oxidizing, bleaching, or antiseptic agent. It is also hazardous at increased concentrations. It is therefore crucial to monitor the presence and concentration of H2O2, particularly in the vapor phase. However, it remains a challenge for many state-of-the-art chemical sensors (e.g., metal oxides) to detect hydrogen peroxide vapor (HPV) because of the interference of moisture in the form of humidity. Moisture, in the form of humidity, is guaranteed to be present in HPV to some extent. To meet this challenge, herein, we report a novel composite material based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) doped with ammonium titanyl oxalate (ATO). This material can be fabricated as a thin film on electrode substrates for use in chemiresistive sensing of HPV. The adsorbed H2O2 will react with ATO, causing a colorimetric response in the material body. Combining colorimetric and chemiresistive responses resulted in a more reliable dual-function sensing method that improved the selectivity and sensitivity. Moreover, the composite film of PEDOT:PSS-ATO could be coated with a layer of pure PEDOT via in situ electrochemical synthesis. The pure PEDOT layer was hydrophobic, shielding the sensor material underneath from coming into contact with moisture. This was shown to mitigate the interference of humidity when detecting H2O2. A combination of these material properties makes the double-layer composite film, namely PEDOT:PSS-ATO/PEDOT, an ideal sensor platform for the detection of HPV. For example, upon a 9 min exposure to HPV at a concentration of 1.9 ppm, the electrical resistance of the film increased threefold, surpassing the bounds of the safety threshold. Meanwhile, the colorimetric response observed was 2.55 (defined as the color change ratio), a ratio at which the color change could be easily seen by the naked eye and quantified. We expect that this reported dual-mode sensor will find extensive practical applications in the fields of health and security with real-time, onsite monitoring of HPV.
A Machine Learning Approach to Robot Localization Using Fiducial Markers in RobotAtFactory 4.0 Competition
Authors: Klein Luan C. , Braun João , Mendes João , Pinto Vítor H. , Martins Felipe N. , de Oliveira Andre Schneider , Wörtche Heinrich , Costa Paulo , Lima José
Published: March 2023

Localization is a crucial skill in mobile robotics because the robot needs to make reasonable navigation decisions to complete its mission. Many approaches exist to implement localization, but artificial intelligence can be an interesting alternative to traditional localization techniques based on model calculations. This work proposes a machine learning approach to solve the localization problem in the RobotAtFactory 4.0 competition. The idea is to obtain the relative pose of an onboard camera with respect to fiducial markers (ArUcos) and then estimate the robot pose with machine learning. The approaches were validated in a simulation. Several algorithms were tested, and the best results were obtained by using Random Forest Regressor, with an error on the millimeter scale. The proposed solution presents results as high as the analytical approach for solving the localization problem in the RobotAtFactory 4.0 scenario, with the advantage of not requiring explicit knowledge of the exact positions of the fiducial markers, as in the analytical approach.
Static Positioning under Tree Canopy Using Low-Cost GNSS Receivers and Adapted RTKLIB Software
Authors: Tomaštík Julián , Everett Tim
Published: March 2023

The decrease in costs and dimensions of GNSS receivers has enabled their adoption for a very wide range of users. Formerly mediocre positioning performance is benefiting from recent technology advances, namely the adoption of multi-constellation, multi-frequency receivers. In our study, we evaluate signal characteristics and horizontal accuracies achievable with two low-cost receivers—a Google Pixel 5 smartphone and a u-Blox ZED F9P standalone receiver. The considered conditions include open area with nearly optimal signal reception, but also locations with differing amounts of tree canopy. GNSS data were acquired using ten 20 min observations under leaf-on and leaf-off conditions. Post-processing in static mode was conducted using the Demo5 fork of the RTKLIB open source software, which is adapted for usage with lower quality measurement data. The F9P receiver provided consistent results with sub-decimeter median horizontal errors even under tree canopy. The errors for the Pixel 5 smartphone were under 0.5 m under open-sky conditions and around 1.5 m under vegetation canopy. The adaptation of the post-processing software to lower quality data was proven crucial, especially for the smartphone. In terms of signal quality (carrier-to-noise density, multipath), the standalone receiver provided significantly better data than the smartphone.
The Burnout and Professional Deformation of Latvian Healthcare Workers during the COVID-19 Pandemic at the Traumatology and Orthopaedics Hospital
Authors: Nagle Evija , Cerela-Boltunova Olga , Blumberga Solveiga , Mihailova Sandra , Griskevica Inguna
Published: March 2023

The COVID-19 pandemic is a global health crisis, which has created an additional burden on the healthcare system and has caused enormous stress and emotional burnout among healthcare workers (HCWs). The purpose of the study is to investigate the phenomena of emotional burnout and the professional deformation of HCWs. The emotional burnout phenomenon of the HCWs was studied using the Maslach Burnout Inventory–Human Services Survey. In addition, the Professional Deformation Survey, based on scientific literature and research works, was developed. The survey consisted of 4 subscales distinguishing: aggression, authoritarianism, demonstrativeness, and conservatism. The survey results showed a high level of emotional exhaustion, a medium level of depersonalization, and a low level of personal achievement reduction. The Professional Deformation Survey showed good reliability for the whole sample in all four subscales. Results of the professional deformation study revealed that 29% of respondents manifest aggression while performing their professional activities. Authoritarianism can be observed in 18% of respondents, demonstrativeness in—31%, and professional deformation manifested as conservatism in—22% of HCWs. Data obtained on burnout and the professional deformation of the HCWs proves that the healthcare system and health organizations have reason to be concerned about the mental well-being of HCWs and the quality of healthcare service provision.
Online Harassment in Sri Lanka: A Thematic Analysis
Authors: Harasgama Kushanthi S. , Jayamaha Samurdhi
Published: March 2023

Online harassment has become a growing menace worldwide for which every nation is trying to find a solution. Existing literature demonstrates that online harassment is widespread in diverse forms and so is its impact on the victims. Despite the lack of any comprehensive studies in this area, there is sufficient evidence to demonstrate the prevalence of online harassment in Sri Lanka and the need to find effective solutions to it. In such circumstances, this study aims to understand the nature of online harassment in the Sri Lankan context using qualitative research methodology. To that end, the study uses thematic analysis for analysing the data collected through semi-structured interviews. The thematic analysis was employed for the study as it assists in classifying complex qualitative data into different and simplified themes for better understanding and interpretation of such data. Among other findings, the analysis revealed three global themes, namely the motives of the perpetrators, the impact on victims, and remedies. Under each global theme, the study revealed various organising and basic themes, also indicating that the motives of the perpetrators and the impact on the victims are closely connected. It further reveals that impacts could be extremely serious, ranging from helplessness to suicidal thoughts, humiliation to broken relationships, and even having adverse impacts on the careers of victims. The study also found that the available remedies are not systematic or strong enough to meet the expectations of the victims. Thus, we conclude that the threat from online harassment in Sri Lanka is similar to that in any other country, requiring immediate and well-planned legal and policy responses, as exposed by the key themes identified in the study.
Dimensions That Influence the Creation of Brand Value of a Music Event and Its Influence on Attendee Satisfaction
Authors: García-de-Soto-Camacho Elena , Garcia-Gordillo Miguel Angel , Vaca-Acosta Rosa María
Published: March 2023

Background: Music festivals are part of the cultural industry, and have become an ever-growing phenomenon. It is essential for organisers to identify whether the marketing strategies implemented are positive and effective in generating a competitive advantage. The aim of this study is to identify the elements that make up the brand equity of an emerging music festival, and to find out whether the overall brand equity determines the satisfaction and subsequent behaviours of festival-goers. Methods: Quantitative research was used by conducting an ad hoc structured survey during the development of a live music festival in May 2022. The questionnaire collects information about dimensions that make up the global brand value and how they influence satisfaction and behavioural intentions, consisting of a total of 33 indicators.; Results: Awareness, perceived quality, and loyalty are the most influential dimensions in shaping the brand of a festival. There is a correlation between the overall brand value and the satisfaction of the attendees, and that the latter influences the subsequent loyalty and recommendation of the event. Conclusions: The causal relationships between the dimensions of brand equity and overall brand equity are shown, where three of the four hypotheses are accepted. Similarly, the three hypotheses related to the influence of overall brand image and behavioural intentions are also accepted.
Lituanistinių darbų vertinimo istorijos puslapis: termino ir metodo akcentai Antano Mažiulio recenzijose
Authors: Šidiškienė Irma
Published: March 2023

A Page in the History of the Evaluation of Lithuanian Studies: The Emphasis on the Term and Method in the Reviews by Antanas Mažiulis.

One of the perspectives of research on the history of evaluation of ethnological works is to analyse reviews of ethnological and ethnographic works. We have chosen Antanas Mažiulis (1914–2007), who wrote many reviews of works in Lithuanistic studies. The aim of the article is to reveal how Mažiulis understood, appreciated and critically approached the science of ethnology. Since his reviews covered a wide range of topics and issues, we will concentrate only on the analysis of terms and methodological issues in them.

Key words: Antanas Mažiulis, reviews, lituanistic studies, terms, methods.
Infl uence of self-discharge generator radiation on the growth of spirulina biomass
Authors:   Plekhanov Russian University of Economics, Moscow, Russian Federation, Eliseeva L.G. , Galkin Yu.A. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation, Mazanov A.A. ,   Plekhanov Russian University of Economics, Moscow, Russian Federation
Published: March 2023

The article discusses the possibility of using the electromagnetic fi eld of a high-frequency plasma generator based on self-discharge to activate the processes of spirulina growth and metabolism during cultivation in deep culture. It is shown that the eff ect of this EMF on the spirulina biomass leads to the activation of metabolic processes, as a result of which an increase in the growth rate of the culture and the duration of its storage is observed. There is also an increase in the activity of synthesis of chlorophyll and a complex of biologically active substances with antioxidant activity.
The role of the quality of therapeutic alliance between the doctor and relatives of a schizophrenia patient at the outpatient stage of treatment
Authors:   Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Sleptsov A. I. , Minenko I. A. ,   Sechenov First Moscow State Medical University of the Ministry of Health of Russia
Published: March 2023

This article presents an analysis of modern scientific data on the role of relatives of schizophrenia patients in the effectiveness of the treatment process at the outpatient stage. Data on the psychological types of attitudes of relatives of schizophrenia patients both to the disease itself and to the ongoing treatment, as well as data on the importance of using various psychotherapeutic methods to improve the effectiveness of the treatment process, are summarized.
Online Lodging Service in Industry
Authors:   Departemen Ilmu Komunikasi, Universitas Komputer Indonesia, Indonesia, Permatasari S , Hassanah Hetty ,   Departemen Ilmu Hukum, Universitas Komputer Indonesia, Indonesia
Published: March 2023

The purpose of this study is to find out the marketing strategies of an online lodging service. This study used descriptive qualitative methods for several online-based lodging services. The results of this study are the development of information technology has played an important role in providing convenience for people, especially in the world of online business. The focus includes economic entrepreneurship, business, communication, and information technology. This online lodging service becomes a media that provides business opportunities for everyone who can improve the Indonesian economy.
Waste Bank as Green Business
Authors:   Departemen Ilmu Hubungan Internasional, Universitas Komputer Indonesia, Indonesia, Putri S O , Mauludin F ,   Departemen Ilmu Sosial dan Ilmu Politik, Universitas Komputer Indonesia, Indonesia
Published: March 2023

The purpose of this research is to build a waste bank business using a mobile application. The method used in this research is descriptive method using a qualitative approach. Given the increasingly widespread problem of waste, one solution to this problem is that waste is processed through a waste bank. With an integrated special application, it can display a map of the location of waste banks spread across a number of areas, so that later it can be easier for the community. In addition, information about waste banks and waste education will be displayed in the application as an educational tool. The results of this study are using a mobile application to search for waste banks and increase public knowledge about waste.
Word of Mouth in Digital Business
Authors:   Departemen Komputerisasi Akuntansi, Universitas Komputer Indonesia, Indonesia, Supriyati S , Arozak G S ,   Departemen Ilmu Komunikasi, Universitas Komputer Indonesia, Indonesia
Published: March 2023

The purpose of this study is to determine changes in information technology marked by the presence of social media that changed the process of delivering information. WOM is usually limited to conventional and now many are switching to e-WOM through social media Instagram. This research was conducted using a qualitative descriptive method that aims to determine the effect produced by Electronic Word of Mouth on the company's brand image. The result shows that that social media helps businessman to promote their services and products using celebrity to convey the messages related to products or services.
Development of Traditional Herbal Medicine through Product Innovation and Marketing Innovation using Business Model Canvas Analysis
Authors:   Magister Manajemen, Universitas Komputer Indonesia, Karlina Karlina , Wahab D A ,   Sya’roni Magister Manajemen, Universitas Komputer Indonesia
Published: March 2023

The Covid-19 pandemic has had a major impact on the world economy, including Indonesia. Large, medium and small scale companies must make various adjustments including product innovation and marketing strategy innovation to face the current economic conditions. One of the small industries affected is herbal medicine business. The purpose of this research is to develop a traditional herbal medicine business through product innovation and digital marketing strategy innovation to increase consumer buying interest and product selling value using business model canvas analysis and SWOT analysis. This study used descriptive qualitative method and literature study. Data collection techniques using in-depth interviews, observations, and questionnaires for herbal medicine makers, sellers, and consumers. The results show that product innovation and marketing innovation can increase consumer buying interest and increase the selling value of the product. The conclusion of this study, herbal medicine is a traditional drink that can compete and survive the economic crisis through product innovation and marketing innovation that continues to be developed
Analise das técnicas de extração de vítimas na restrição de movimentos da coluna
Authors: Dos Santos Ednei Fernando , Lopes Myrna Marques , Silva Marcelo Donizeti
Published: March 2023

O objetivo do presente estudo é comparar a técnica de extração rápida e o emprego do dispositivo kendrick device extrication durante os processos de extração veicular realizados pelas equipes de emergências. Método: Trata-se de um estudo com análise biomecânica exploratória de movimento da coluna durante diferentes técnicas de extração veicular em 26 voluntários, saudáveis, de ambos os sexos, com estatura e peso variados, inseridos dentro de um veículo e que foram separados para a coleta de forma aleatória. Resultados: O tempo de extração foi significativamente menor usando a técnica de extração rápida para todos os voluntarios (vítimas). Os ângulos de giros da cabeça foram ligeiramentes maiores usando extração rápida, exceto nos voluntários obesos e de grandes estaturas. Conclusão: Concluímos que a escolha da técnica de extração está diretamente associada com a condição da vítima pós acidente e que as equipes de atendimento pré-hospitalares devem estar preparadas para realizarem a escolha correta da técnica de extração para cada vítima, e não empregar um padrão corriqueiro, engessado e desatualizado, pois cada paciente apresenta sua individualidade biológica, anatomica, clínica e lesiva.
Atividade de monitoria em habilidades clínicas I no Centro Universitário do Estado do Pará: um relato de experiência
Authors: Vallinoto Mariana Cayres , Aita Clarisse Gripp , Chada Alícia Salomão , Leite Nathália Yumi Nagano , Da Costa Marcella Abreu , Zaccardi Maria Luiza Del Tetto , De Oliveira Pedro Arthur Rodrigues , Caldato Cássio
Published: March 2023

Introdução: A semiologia médica é uma área de estudo acerca dos sinais e sintomas que um paciente pode apresentar, que aborda o desenvolvimento da relação médico-paciente mediante o exame clínico e a anamnese. Dessa forma, a monitoria em semiologia médica se constitui de suma importância para o desenvolvimento de novas habilidades e de raciocínio clínico do corpo discente. Objetivo: Relatar a experiência desenvolvida na atividade de monitoria em semiologia médica. Método: Trata-se de um estudo descritivo, do tipo relato de experiência, realizado a partir da vivência de monitoria de habilidades clínicas I (primeiro semestre) no segundo semestre de 2021 e no primeiro semestre de 2022. Discussão: A possibilidade do contato com a docência de habilidades clínicas permite aos monitores o aprimoramento dos conhecimentos em semiologia médica, acolhimento dos alunos de modo individualizado e a busca por novas experiências de qualificação acadêmica. Conclusão: A monitoria se mostra fundamental nesse processo de ensino-aprendizado da semiologia e contribui não só para o conhecimento dos discentes, como também para quem realiza a monitoria, constituindo um aprendizado de grande relevância durante o período acadêmico.
Abordagem terapêutica da Esquizofrenia e novas evidências: uma revisão integrativa
Authors: Dos Santos Jackeline Ribeiro , Da Silva Isabela Araújo , Marques Brener Raphael de Carvalho , Wanzeler Lílian Raquel Lima Roseno , Garcia Henrique Nascimento Ribas , Diniz Gabriel Lucena , Utino Bárbara Manha , Perone Luiza Marcondelli , Dias Katarina Almeida , Santos Monique Andrade , De Sá Junior Antonio Carlos Barros Nogueira , Praça Gabriela de Menezes Leite , Barcelos Maria José Cançado , Da Silva Andrew Pereira
Published: March 2023

A esquizofrenia é um importante problema de saúde pública atual, sendo uma das doenças mentais graves de relevante incidência na população mundial. O presente estudo de revisão buscou avaliar novas evidências na abordagem terapêutica da esquizofrenia, documentadas por meio de estudos clínicos e randomizados. Trata-se de uma pesquisa de revisão integrativa realizada por meio da base de dados PubMed, que levou em consideração os seguintes critérios de inclusão: ensaios clínicos e testes controlados e randomizados; artigos publicados no último ano; que possuíam texto completo disponível e que abordassem acerca de novas evidências no manejo da esquizofrenia. Ficou constatado que o brexpiprazol auxiliou na melhora dos níveis de funcionamento em atividades socialmente úteis, relações pessoais e sociais, autocuidado e comportamentos perturbadores e agressivos. Ademais, a roluperidona trouxe melhorias em diferentes índices de sintomas negativos e funcionamento social do paciente, sendo bem tolerada e sem efeitos adversos, o que a torna uma importante aliada para o manejo dos sintomas negativos e funcionamento diário do paciente. Outro ponto constatado é a formulação de palmitato de paliperidona de 6 meses, a qual apresentou eficácia comparável com as formulações de 1 e de 3 meses da mesma medicação, com perfis de segurança semelhantes aos demais, fornecendo regimes de doses mais flexíveis para um manejo efetivo de tais pacientes. Por fim, a blonanserina em adolescentes com esquizofrenia apresentou melhoria de forma significativa nos sintomas psiquiátricos, com eficácia e segurança semelhante ao encontrado em adultos, sendo verificados efeitos mínimos sobre mudança de peso e parâmetros metabólicos analisados.
Modos de adaptación y su asociación con el adulto mayor residente en un asilo
Authors: Cevallos Liliana Estefanía Bustamante , Mera Beatriz Venegas
Published: March 2023

Objetivo: Identificar los modos de adaptación y su asociación con el adulto mayor residente en un asilo. Metodología: Este estudio corresponde a un diseño descriptivo siendo una investigación cualitativa. La muestra estuvo conformada por 15 adultos mayores. Se utilizó la técnica de recolección de datos mediante una entrevista semiestructurada.Resultados: El rango de edad fue de 75 a 90 años ssiendo 6 mujeres y 9 hombres. Se obtuvieron cuatro categorías, modo de adaptación fisiológico: presenta enfermedades, modo de adaptación de autoconcepto: creencias de fe, modo de desempeño de roles: interacción con las personas que lo rodean y modo de adaptación de interdependencia: apoyo familiar.Conclusión: Se concluye que la mayoría de los adultos mayores presentan en el modo de adaptación de interdependencia un poco apoyo de parte de su círculo familiar.
Benefícios da frenotomia lingual no aleitamento materno
Authors: Lima Rayssa Nayra de Albuquerque , Sales Manoela Trindade , Do Nascimento Jamilly Corrêa , Da Silva Zuleni Alexandre , Lima Rebeca Gerhardt da Costa , Do Nascimento Ana Larissa Oliveira , Hanna Leila Maués Oliveira
Published: March 2023

O presente estudo tem como objetivo avaliar os benefícios da técnica cirúrgica de frenotomia lingual em recém-nascidos para a melhoria na qualidade da amamentação, bem como o desenvolvimento nutritivo das crianças. A metodologia deste trabalho constituiu-se em entrevista remota com 43 mães de bebês, que realizaram a cirurgia de frenotomia lingual em um intervalo de 5 anos. A partir dos resultados dessa pesquisa, foi possível concluir que a frenotomia lingual apresenta grandes benefícios para a manutenção da amamentação.
A memória histórica da instituição Polícia Militar
Authors: Casagrande Carlos Henrique , Gritten Eduardo Kendi Fujioka
Published: March 2023

Este artigo aborda a importância da memória institucional e as formas de resgatar e preservar essas memórias. Para esta pesquisa utilizou-se o método dedutivo a partir de bibliografias de obras que abordam a formação histórica, como documentos, e acervos das instituições organizacionais de Polícia Militar. Foram referenciadas materiais e autores historiográficos com publicações sobre a Instituição Polícia Militar. O objetivo foi identificar a importância do relato histórico para a Instituição Polícia Militar do Paraná, e se ela disponibiliza um acervo onde acadêmicos possam realizar pesquisas de caráter histórico. Resultados: A história Militar registrada no Brasil, mantém seu foco nas realizações das Forças Armadas, e nos registros históricos dos Estados de São Paulo, Minas Gerais e Rio Grande do Sul. As outras instituições de polícias militares aparecem como coadjuvante nesses relatos históricos. Conclusão: Existe a necessidade de sensibilizar os gestores da Polícia Militar do Paraná, para a preservação da memória da instituição. A sugestão seria a criação de um local onde pudesse ser armazenado os acervos bibliográficos, materiais e equipamentos antigos, materiais de audiovisuais, fotografias, banco de depoimentos, entre outros, de forma a facilitar possíveis pesquisas.
A reatividade negativa oriunda da poliquimioterapia imposta na Hanseníase
Authors: De Almeida Erika Leite Moitinho Magalhães , Abreu Rhaymysom Jasmy Gomes , Bourdokan Katia Aparecida Scarpari , Diniz Gabriel Lucena , De Siqueira Tainara Suélen , Utino Bárbara Manha , Dos Santos Adriano Paulo da Cruz , Fiuza Sérgio Botelho , Westphal Leandro , Carneiro Henrique Marreiros Veloso , Francischetti Marina Vieira , De Oliveira Letícia Duarte , Pina Guilherme Cristovam , Pereira Caroline de Oliveira , Acatauassu Sarah Tuma , Sales Paulo Ferreira Luz , Severo Bernardo Rivera Fernandes , De Oliveira René Ochagavia Chagas , Pina Laís Cristovam , Lopes Bianca Castelo , De Oliveira Kércia Costa , Magalhães Mellyna Vilela , Novaes Laiz Gomes Carneiro , Pires Lorena Virgínia Ferreira , Pimenta Gabriela Marques , Diniz Gabrielle Feitosa , Ferreira Anna Maíra Massad Alves , De Lucena Layo Leite , Romão Maria Eduarda Granja Caribé , Borges Luiz Augusto Germano , Rocha Jose Songlei da Silva , Da Silveira Octavio Augustus Garcia , Cartaxo Luana Maria Costa , Cuéllar Pablo Maurício Mejía , Bastos Milena Castro de Oliveira , Casalini Caroline Eickhoff Copetti , Bezerra Ana Carolina Falcão , Fernández Diego Sauma , Sobrinho Filho Divino Santana , Leite Itary Carvalho Silva , Passamani Lara Dalla Bernardina , Pina Luiza Rodrigues Leão
Published: March 2023

Introdução: A hanseníase é uma doença infectocontagiosa, que devido às repercussões clínicas e aos dados epidemiológicos é considerada de notificação compulsória. Contudo, esse transtorno quando é precocemente identificado e adequadamente manejado, evita consideravelmente o círculo vicioso de contágio e as manifestações clínicas que tornam a doença tão alvo de estigma. Objetivo: Descrever a reação negativa oriunda da poliquimioterapia imposta na hanseníase. Metodologia: Trata-se de uma revisão narrativa de literatura, fundamentada nas plataformas do Scielo, Pubmed, Lilacs e demais literaturas pertinentes ao tema, utilizando-se os seguintes descritores: Reação Hansênica, Efeitos Adversos e Poliquimioterapia, no período de janeiro de 2023. Resultados e Discussão:  Atualmente, o protocolo terapêutico voltado para a Hanseníase é a poliquimioterapia e possui boa eficácia e tolerância pela maioria dos pacientes.  No advém, a minoria destes apresenta reações adversas que variam de leve a exacerbadas e que devem ser devidamente classificados e orientados para outras opções farmacológica, objetivando impedir que o paciente abandone o tratamento, junto às enormes repercussões oriundas deste, e propiciar melhor qualidade de vida. Conclusão: Estima-se que o tratamento da Hanseníase é algo importante e indispensável para evitar problemas de saúde pública, mas este se baseia em uma alta carga associada de remédios potentes, a qual alguns portadores possuem sensibilidade e se orientados, podem continuar o tratamento até o alcance da cura.
Correlatos das quedas em pessoas idosas do Amazonas, Brasil
Authors: Borges Silvia , Silva Jefferson Jurema , Gouveia Élvio Rúbio Quintal
Published: March 2023

Objetivos: (1) Investigar o grau de associação entre as quedas e fatores modificáveis (i.e., equilíbrio, o nível de atividade física, e fatores de risco para a saúde) e não modificáveis (i.e., idade e gênero), e (2) Investigar a associação entre os fatores modificáveis e as quedas depois de controlados a idade e o gênero. Métodos: Este estudo enquadra-se no projeto “Saúde, Estilo de Vida e Aptidão em Adultos e Adultos Idosos do Amazonas (SEVAAI)”. Esta investigação, com um delineamento transversal, 701 idosos, 268 homens e 433 mulheres, entre os 60 aos 92,8 anos de idade, residentes em três municípios do estado do Amazonas: Apuí, Fonte Boa e Manaus. A atividade física, a qualidade de vida e as variáveis sociodemográficas de saúde foram avaliadas através de questionários validados para a população brasileira (entrevistas face-to-face). Resultados: Verificamos que a ocorrência de quedas na população estudada estava correlacionada significativamente e positivamente com os fatores de risco para a saúde. A idade não apresentou diferenças significativas entre os idosos com quedas (70,35 anos) e idosos sem quedas (70,37 anos). Menores níveis de atividade física e menores scores da escala de Fullerton estavam relacionados com a idade. A análise revelou que depois de controlados por fatores de risco não modificáveis (i.e., a idade e gênero), apenas duas variáveis predizem a ocorrência de quedas: os fatores de risco para saúde e o score da escala de Fullerton.  Conclusão: Os participantes que não reportaram quedas apresentaram menos fatores de risco para a saúde, um nível de atividade física superior e melhores scores na escala de Fullerton comparativamente aos participantes que reportaram quedas.
Eficácia do tratamento de Mieloma Múltiplo no mundo real: estudo de série de 123 casos institucionais com análise de sobrevivência
Authors: E Gomes Laura de Castro , Gonzaga Camila Ramos , De Andrade Helena Alicia Santos , Bueno Ana Paula Pinto de Araújo , Ferreira Bruno Ávila , De Bastos Marcos
Published: March 2023

O Mieloma Múltiplo (MM) é uma neoplasia maligna hematológica incurável acometendo cerca de 7.000 pessoas no Brasil, apresentando mediana de sobrevida global de cerca de 72 meses. O objetivo do estudo foi analisar a sobrevida dos pacientes com MM em tratamento em um hospital público de Minas Gerais entre 2011 e 2022. Foram avaliados pacientes ambulatoriais e hospitalares, com metodologia de Kaplan-Meier e LogRank. Os pacientes foram tratados com inibidor de proteossomos, imunomodulador, corticosteróide, quimioterapia, Transplante Autólogo de Células Tronco (TACT) e suporte. Foram estudados 123 pacientes, sendo 68 (54,8% do total) mulheres, com idade média 67,3 (DP ± 10,5) anos numa série de casos consecutivos. Um total de 28 pacientes (22,6%) realizou TACT. O tempo médio de acompanhamento após diagnóstico foi de 35,3 meses (± 30,0). Houve 50 óbitos (40,3%). A mediana de sobrevida foi de 69 meses com a probabilidade de sobrevida em 36 meses de 68,2% (IC 95% 59,7%-78,0%) e em 60 meses, 56,1% (IC 95% 46,3%-68,0%). Melhores resultados foram encontrados em pacientes com idade menor que 65 anos ao diagnóstico (teste LogRank P=0.02) e nos casos transplantados (P<0.01). Concluímos que a mediana de sobrevida global foi cerca de 6 anos com melhores resultados em pacientes menores de 65 anos e transplantados. Os resultados foram dentro do esperado, com os recursos disponibilizados. Com a introdução de novos medicamentos e procedimentos, é possível que haja prolongamento da sobrevida global tornando necessário novos pontos finais de observação além da sobrevida global.
Prevalência e principais manifestações do long Covid: um desafio para a medicina atual
Authors: Villacis Nicole Daniela Ledesma , Montesinos Carlos Enrique Flores , González Andrés Felipe Mercado , Garzón Marcela Doménica Moncayo
Published: March 2023

Introdução: A COVID-19 produz sintomas persistentes e complicações após a infecção. A Síndrome Pós-COVID-19 é o conjunto de manifestações clínicas, geradas durante ou após a infecção pelo COVID 19, esta síndrome requer uma abordagem multidisciplinar que permita o acompanhamento dos pacientes envolvidos e a aplicação de medidas preventivas. O termo “Long COVID” é preferido para sintomas persistentes com duração superior a quatro semanas. Objetivo: Determinar a prevalência, principais manifestações, fisiopatologia e fatores de risco do Long COVID. Metodologia: Uma revisão sistemática foi realizada usando o método PRISMA. Resultados: 450 artigos foram recuperados na busca realizada nas bases de dados PubMed e Scopus, após a aplicação dos critérios de elegibilidade, obteve-se um total de 29 publicações. Conclusões: A prevalência de Long COVID variou entre 48,9% e 100%, os potenciais fatores de risco foi sexo feminino, faixa etária de 49 a >55 anos, maior número de sintomas diferentes na primeira semana de infecção, presença de comorbidades, internação na Unidade de Terapia Intensiva; e sua fisiopatologia se deve a diferentes mecanismos de resposta do sistema imunológico contra a infecção e seus efeitos a longo prazo.
Síndrome Mielodisplásico por deleción del brazo largo del cromosoma 5. Reporte de caso y revisión de la literatura – myelodysysplasic
Authors: Sánchez Alexander Francisco Romero , Reibán Esteban Adrián Espinoza
Published: March 2023

El síndrome mielodisplásico constituye un grupo de entidades hematológicas clonales caracterizada por citopenias marcadas y trombocitopenia solo el 20% de las mismas presenta anormalidades citogenéticas como la deleción del brazo largo del cromosoma 5. Para su diagnóstico se realiza frotis en sangre periférica evidenciando cambios displásicos, biopsia de médula ósea en la que encontramos una médula hipercelular con displasia de la serie roja y megacariocitos y estudio citogenético. El tratamiento se basa en soporte transfusional cuando es necesario y lenalidomida en 10 mg/kg día mejorando la sintomatología. Se presenta caso clínico de paciente femenina de 90 años de edad con presencia de síntomas B, anemia de larga data, Leucopenia y trombocitopenia con la anamenesis y xexámenes complementarios se diagnostica síndrome mielodisplásico por deleción de 5q. Se da tratamiento con lineladomida con una evolución positiva. El objetivo de este reporte de caso es determinar las principales manifestaciones clínicas, diagnóstico y tratamiento mejorarando el entendimiento de esta enfermedad.