bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Synthesis and Characterization of Zinc Borophosphates with ANA‐Zeotype Framework by the Microwave Method.
Authors: Song Yu , Ding Ling , An Qingda , Zhai Shangru , Song Xiaowei
Published: July 2013

Large single crystals of (NH4)16 [Zn16B8P24O96] are synthesized by microwave‐assisted solvothermal reaction of ZnCl2, (NH4)2PO4, H3BO3, and ethylene glycol (autoclave, microwave irradiation, 200 °C, microwave power of 600 W for 5 min and 400 W microwave power for 2 h).
ChemInform Abstract: pH‐Dependent Assembly of 1D—2D Structures Based on Both {V10O28} and [NiMo6O24H6]4‐ Units: Synthesis, Structure and Magnetic Properties.
Authors: Yang Yanyan , Xu Lin , Li Fengyan , Qu Xiaoshu
Published: July 2013

Compounds (IV) and (V) crystallize in the triclinic space group P$\bar 1$ with Z = 1 (single crystal XRD).
ChemInform Abstract: Sandwich‐Type Tungstoantimonates Decorated by the Heterometallic 3d—5p Clusters.
Authors: Duan Hui , Zhang Zhi‐Ming , Han Xin‐Bao , Chen Yi‐Zhen , Shen Jian‐Qiang , Wang Wei‐Peng , Zheng Xiao‐Tao , Zhou Huan‐Yu , Wang En‐Bo
Published: July 2013

The crystal structures of compounds (III) and (V) are determined by single crystal XRD.
ChemInform Abstract: Ternary Rare‐Earth Ruthenium and Iridium Germanides RE3M2Ge3 (RE: Y, Gd—Tm, Lu; M: Ru, Ir).
Authors: Oliynyk Anton O. , Stoyko Stanislav S. , Mar Arthur
Published: July 2013

The compounds Ln3M2Ge3 (Ln: Y, Gd—Tm, Lu; M: Ru, Ir) are prepared by arc melting of the elements and subsequent annealing at 800 °C for 12 d.
ChemInform Abstract: Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ‐Valerolactones.
Authors: Otsuka Yasunari , Takada Hisashi , Yasuda Shigeo , Kumagai Naoya , Shibasaki Masakatsu
Published: July 2013

The title reaction, promoted by a soft Lewis acid/hard Broensted base cooperative catalyst, affords homoallylic alcohols with a Z‐configured α,β‐unsaturated nitrile from aromatic aldehydes with electron‐donating substituents, allowing for rapid access to unsaturated γ‐valerolactones like (VIII), which is a key intermediate in the synthesis of fostriecin.
ChemInform Abstract: Nitration of Carbonic, Sulfuric and Oxalic Acid‐Derived Amides in Liquid Carbon Dioxide.
Authors: Kuchurov Ilya V. , Fomenkov Igor V. , Zlotin Sergei G. , Tartakovsky Vladimir A.
Published: July 2013

N‐Nitro‐ and N,N‐dinitroamides of carbonic, sulfuric and oxalic acids are prepared by nitration of the corresponding amides with dinitrogen pentoxide in liquid carbon dioxide.
ChemInform Abstract: Facile Synthesis of N‐Substituted Amides from Alcohols and Amides.
Authors: Okada Iku , Chiba Kazuhiro , Kitano Yoshikazu
Published: July 2013

Facile methods are developed for the conversion of tertiary aliphatic alcohols into the corresponding N‐substituted amides under either conditions A) or B).
ChemInform Abstract: P4VP‐H2SO4‐Catalyzed Chemoselective Protection of Aldehydes to Acylal Along with Deprotection Reactions.
Authors: Dutta Papia , Sarma Parishmita , Borah Ruli
Published: July 2013

Poly(4‐vinylpyridine)‐supported sulfuric acid is an excellent reusable heterogeneous catalyst for the chemoselective protection of a variety of aldehydes as acetals as well as the deprotection of acetals.
ChemInform Abstract: Multifunctional Thiols from the Highly Selective Reaction of Mercaptoalcohols with Chlorosilanes.
Authors: Jennings Abby R. , Son David Y.
Published: July 2013

The silylation of mercaptoalcohols proceeds selectively on the hydroxy group to afford thiolated alkoxysilanes.
ChemInform Abstract: A Novel Triphosphoramidite Ligand for Highly Regioselective Linear Hydroformylation of Terminal and Internal Olefins.
Authors: Chen Caiyou , Qiao Yu , Geng Huiling , Zhang Xumu
Published: July 2013

Ligand (I) gives good results in the title reaction.
ChemInform Abstract: Asymmetric Michael Reaction Catalyzed by Proline Lithium Salt: Efficient Synthesis of L‐Proline and Isoindoloisoquinolinone Derivatives.
Authors: Xu Kun , Zhang Sheng , Hu Yanbin , Zha Zhenggen , Wang Zhiyong
Published: July 2013

The described transformations can be performed with comparable results on a gram scale.
ChemInform Abstract: An Electrophilic Hypervalent Iodine Reagent for Trifluoromethylthiolation.
Authors: Shao Xinxin , Wang Xueqiang , Yang Tao , Lu Long , Shen Qilong
Published: July 2013

The air‐ and moisture‐stable reagent (I) allows the direct transfer of the ‐S‐CF3 group to different classes of substrates such as β‐ketoesters, boronic acids, alkynes, and aldehydes under mild conditions.
ChemInform Abstract: Mild and Rapid Pd‐Catalyzed Cross‐Coupling with Hydrazine in Continuous Flow: Application to the Synthesis of Functionalized Heterocycles.
Authors: DeAngelis Andrew , Wang Dong‐Hui , Buchwald Stephen L.
Published: July 2013

Continuous flow or batch reactions of the arylhydrazines, formed in the first step, with β‐diketones, benzaldehyde and ketones allows the synthesis of pyrazoles, hydrazones, and indoles.
ChemInform Abstract: Organocatalytic Asymmetric Cross‐Aldol Reaction of 2‐Chloroethoxy Acetaldehyde: Diversity‐Oriented Synthesis of Chiral Substituted 1,4‐Dioxanes and Morpholines.
Authors: Sawant Rajiv T. , Stevenson Joanne , Odell Luke R. , Arvidsson Per I.
Published: July 2013

The new and facile title reaction affords the novel 1,3‐diols (III) with excellent enantioselectivities and moderate diastereoselectivities.
ChemInform Abstract: DMC‐Mediated One‐Pot Synthesis of Biaryl Ketones from Aryl Carboxylic and Boronic Acids.
Authors: Pathak Arunendra , Rajput Chatrasal S. , Bora Pushkar S. , Sharma Somesh
Published: July 2013

Carboxylic acids, activated in situ with DMC, undergo Pd‐catalyzed cross‐coupling reaction with arylboronic acids to produce unsymmetrical aromatic ketones.
ChemInform Abstract: Sulfoximine Directed Intermolecular o‐C—H Amidation of Arenes with Sulfonyl Azides.
Authors: Yadav M. Ramu , Rit Raja K. , Sahoo Akhila K.
Published: July 2013

A new Ru(II)‐catalyzed intermolecular ortho‐C—H amidation of various arenes with several sulfonyl azides is reported.
ChemInform Abstract: Chemoselective Synthesis of Aryl Carboxamido Sulfonic Acid Derivatives.
Authors: Lin Po‐Chiao , et al. et al.
Published: July 2013

A one‐pot two‐step synthesis of the title compounds, which is more efficient than currently known procedures, is developed and expanded to the synthesis of sulfonic esters, thiosulfonates, and a sulfonyl azide.
ChemInform Abstract: Copper‐Catalyzed Trifluoromethylation of Arylsulfinate Salts Using an Electrophilic Trifluoromethylation Reagent.
Authors: Lin Xiaoxi , Wang Guimei , Li Huaifeng , Huang Yuanyuan , He Weiming , Ye Dandan , Huang Kuo‐Wei , Yuan Yaofeng , Weng Zhiqiang
Published: July 2013

The presented reaction is compatible with a wide range of functional groups in arylsulfinates (I) expanding the scope of Cu‐catalyzed electrophilic triflouromethylation reactions.
ChemInform Abstract: Pd‐Arylurea Complexes for the Heck Arylation of Crotonic and Cinnamic Substrates.
Authors: Smith Matthew R. , Kim Jung Yun , Ciufolini Marco A.
Published: July 2013

The catalyst system shows an unusual preference for deactivated, electron‐rich aryl iodides.
ChemInform Abstract: Synthesis of 1‐Arylnaphthalenes by Gold‐Catalyzed One‐Pot Sequential Epoxide to Carbonyl Rearrangement and Cyclization with Arylalkynes.
Authors: Gudla Vanajakshi , Balamurugan Rengarajan
Published: July 2013

A one‐pot method for the inter‐ and intramolecular regioselective synthesis of 1‐arylnaphthalenes via a Au‐catalyzed epoxide to carbonyl rearrangement, electrophilic addition to the alkyne, and subsequent benzannulation is presented.
ChemInform Abstract: Organocatalytic 1,4‐Conjugate Addition of Ascorbic Acid to α,β‐Unsaturated Aldehydes: Bio‐Inspired Total Syntheses of Leucodrin, Leudrin and Proposed Structure of Dilaspirolactone.
Authors: Wang Zhaofeng , Zhao Kun , Fu Junkai , Zhang Junlin , Yin Weiyu , Tang Yefeng
Published: July 2013

A novel organocatalytic addition of ascorbic acid to α,β‐unsaturated aldehydes via a tandem 1,4‐conjugate addition—hemiacetalization—hemiketalization reaction is developed.
ChemInform Abstract: Pd/C—Cu‐Mediated Direct and One‐Pot Synthesis of γ‐Ylidene Butenolides.
Authors: Rambabu D. , Bhavani S. , Nalivela Kumara Swamy , Mukherjee Soumita , Rao M. V. Basaveswara , Pal Manojit
Published: July 2013

It is found that the catalytic system efficiently promotes the coupling of iodoacrylic acid with terminal alkynes to form the target compounds with high regio‐ and stereoselectivity.
ChemInform Abstract: Synthesis and Structure of Aryl(hetaryl)spiropyrrolidones.
Authors: Berestovitskaya V. M. , Litvinov I. A. , Vasil'eva O. S. , Nikonorov A. A. , Ostroglyadov E. S. , Krivolapov D. B.
Published: July 2013

Hydrogenation of diastereomerically pure nitroethylpyrrolidinecarboxylates (I) is accompanied by intramolecular acylation of the formed amino group to furnish diastereomerically pure spiropyrrolidines (II).
ChemInform Abstract: Three‐Component Coupling Synthesis of Diversely Substituted N‐Aryl Pyrroles Catalyzed by Iron(III) Chloride.
Authors: Sarkar Soumen , Bera Krishnendu , Maiti Sukhendu , Biswas Srijit , Jana Umasish
Published: July 2013

Nitroalkenes (I), 1,3‐dicarbonyl compounds, and primary aromatic amines react via a catalytic sequence of Fe(III)‐catalyzed amination/Michael/cycloisomerization reactions to efficiently give the title compounds (IV) (26 examples).
ChemInform Abstract: Synthesis of Highly Functionalized Pyrrolidines as Tunable Templates for the Direct Access to (.+‐.)‐Coerulescine and the Tricyclic Core of Martinellines.
Authors: Le Goff Ronan , Lawson Ata Martin , Daich Adam , Comesse Sebastien
Published: July 2013

A series of tetrasubstituted pyrrolidines is synthesized by an aza‐Michael induced ring‐closure tandem reaction of bromide (II) with Michael acceptors (I), (IV), and (VI).
ChemInform Abstract: Domino Synthesis of 3‐Amino‐8‐hydroxy‐1,6‐dioxo‐2,7‐diazaspiro [4.4]non‐3‐ene‐4‐carbonitriles.
Authors: Fedoseev Sergey V. , Ershov Oleg V. , Belikov Mikhail Yu. , Lipin Konstantin V. , Bardasov Ivan N. , Nasakin Oleg E. , Tfeenko Viktor A.
Published: July 2013

Treatment of substrates (I) with aqueous NaOH results in cyclization to the spirocyclic title compounds (II) in good yields.
ChemInform Abstract: Fluoride‐Catalyzed Nucleophilic Addition of PhSCF2SiMe3 to Anhydrides: Synthesis of γ‐Difluoromethylated γ‐Lactams.
Authors: Pharikronburee Vannapha , Punirun Teerachai , Soorukram Darunee , Kuhakarn Chutima , Tuchinda Patoomratana , Reutrakul Vichai , Pohmakotr Manat
Published: July 2013

The fluoride‐catalyzed (phenylthio)difluoromethylation of various anhydrides is used as key reaction in the synthesis of difluoromethylated γ‐lactams.
ChemInform Abstract: Ultrasound‐Promoted Synthesis of Novel 2‐Imino‐3‐aryl‐2,3‐dihydrobenzo[d]oxazol‐5‐ol 2‐Iminooxazolidines Derivatives.
Authors: Habibi Davood , Nasrollahzadeh Mahmoud , Sahebekhtiari Hesam , Parish Richard Vernon
Published: July 2013

A facile protocol for the synthesis of the title compounds (III) using an ultrasound‐assisted reaction of p‐benzoquinone and arylcyanamides, and their chemoselective tosylation is presented.
ChemInform Abstract: Aza‐Michael Addition Reactions Between Nitroolefins and Benzotriazole Catalyzed by MCM‐41 Immobilized Heteropoly Acids in Water.
Authors: Xie Shao‐Lei , Hui Yong‐Hai , Long Xiang‐Ju , Wang Chang‐Chun , Xie Zheng‐Feng
Published: July 2013

The reusable catalyst is applied to the preparation of functionalized nitroalkanes bearing a heterocyclic skeleton as products of interest in natural compound synthesis and drug discovery.
ChemInform Abstract: Efficient Transformation of Inactive Nitriles into 5‐Substituted 1H‐Tetrazoles Using Microwave Irradiation and Their Applications.
Authors: Yoneyama Hiroki , Usami Yoshihide , Komeda Seiji , Harusawa Shinya
Published: July 2013

The practical method allows the preparation of various types of tetrazole compounds.
ChemInform Abstract: One‐Step Synthesis of 5,6‐Diaryl Pyridine‐2(1H)‐thiones from Isoflavones.
Authors: Wang Juanjuan , Zhang Zunting , Wang Wenli , Liu Fangfang
Published: July 2013

The title process involves a base‐mediated isoflavone ring opening followed by Knoevenagel condensation between the resulting 1,3‐dicarbonyl intermediate and cyanothioacetamide.
ChemInform Abstract: A Novel Three‐Component [5 + 1] Heterocyclization Leading to 2‐Azafluorenone Synthesis and Its Polyfunctionalizations.
Authors: Li Ying , Fan Wei , Xu Hai‐Wei , Jiang Bo , Wang Shu‐Liang , Tu Shu‐Jiang
Published: July 2013

Highly functionalized 2‐azafluorenones are synthesized by domino reactions involving C1‐aryl acylation, C3‐thiolation, and C4‐cyanation under mild conditions in short reaction times (15‐30 min).
ChemInform Abstract: A Novel Convenient Approach Towards Pyrrolo[1,2‐b]pyridazines Through a Domino Coupling—Isomerization—Condensation Reaction.
Authors: Wang Meng , Tan Cun , He Qian , Xie Yuyuan , Yang Chunhao
Published: July 2013

A novel Pd/Cu catalyzed synthesis of pyrrolopyridazines under mild conditions is developed.
ChemInform Abstract: Trifluoroethanol Solvent Facilitates Selective N‐7 Methylation of Purines.
Authors: Lebraud Honorine , Cano Celine , Carbain Benoit , Hardcastle Ian R. , Harrington Ross W. , Griffin Roger J. , Golding Bernard T.
Published: July 2013

An one‐pot process is elaborated for the preparation of 7‐alkylpurines in trifluoroethanol by a N‐7 alkylation of purines (I) bearing Pmb‐protecting group at N‐9 followed by a microwave‐induced deprotection.
ChemInform Abstract: Synthesis of Linear and Cyclic Compounds Containing the 3,4‐Bis(Furazan‐3‐yl)furoxan Fragment.
Authors: Stepanov A. I. , Astrat'ev A. A. , Dashko D. V. , Spiridonova N. P. , Mel'nikova S. F. , Tselinskii I. V.
Published: July 2013

Reactions of furoxan (I) with a series of N‐ and O‐nucleophiles provides access to novel heterocyclic systems.
ChemInform Abstract: The Staudinger Reaction with 2‐Imino‐1,3‐thiaselenanes Toward the Synthesis of C4 Spiro‐β‐lactams.
Authors: Toyoda Yosuke , Ninomiya Masayuki , Ebihara Masahiro , Koketsu Mamoru
Published: July 2013

A variety of C4 spiro‐β‐lactams are synthesized via the Staudinger reaction of readily available 2‐imino‐1,3‐thiaselenanes (III) with methoxyketene.
ChemInform Abstract: A 12‐Membered to a Strained 11‐Membered Ring: First Stereoselective Total Synthesis of (—)‐Asteriscunolide C (II)
Authors: Fernandes Rodney A. , Chavan Vijay P.
Published: July 2013

employing a ring‐closing metathesis reaction as the key step
ChemInform Abstract: Synthesis of α‐2‐Deoxy‐ulosides by Michael Addition of Hex‐1‐en‐3‐ones
Authors: Lin Hui‐Chang , et al. et al.
Published: July 2013

21 examples
ChemInform Abstract: Quinic Acid Derivatives from Pimpinella brachycarpa Exert Antineuroinflammatory Activity in Lipopolysaccharide‐Induced Microglia
Authors: Lee Seung Young , Moon Eunjung , Kim Sun Yeou , Lee Kang Ro
Published: July 2013

isolation, structure and antineuroinflammatory activity of five new quinic acid derivatives (I) together with ten known quinic acids
ChemInform Abstract: Aculeatusquinones A—D, Novel Metabolites from the Marine‐Derived Fungus Aspergillus aculeatus.
Authors: Chen Li , Zhang Wei‐Wei , Zheng Qiu‐Hong , Liu Qing‐Ying , Zhong Ping , Hu Xiao , Fang Zhe‐Xiang , Zhang Qi‐Qing
Published: July 2013

Aculeatusquinones B (II) and D (IV) demonstrate weak to moderate cytotoxicity against HL‐60, K562, and A‐549 cell lines.
ChemInform Abstract: Ohmic Heating as a New Efficient Process for Organic Synthesis in Water.
Authors: Silva Vera L. M. , et al. et al.
Published: July 2013

Representative organic transformations, a Diels‐Alder reaction, a nucleophilic substitution, an N‐alkylation and a Suzuki cross‐coupling are performed using a direct ohmic heating reactor.
ChemInform Abstract: Behavior of Sheet‐Like Crystalline Ammonium Trivanadate Hemihydrate (NH4V3O8·0.5H2O) as a Novel Ammonia Sensing Material.
Authors: Leonardi S. G. , Primerano P. , Donato N. , Neri G.
Published: July 2013

The layered material NH4V3O8·0.5H2O is prepared by hydrothermal reaction of a neutralized aqueous Na3VO4 solution, (NH4)2SO4, and H2SO4 (pH 2.5, 100 °C, 20—40 min).
ChemInform Abstract: Exfoliated Graphitic Carbon Nitride Nanosheets as Efficient Catalysts for Hydrogen Evolution under Visible Light.
Authors: Yang Shubin , Gong Yongji , Zhang Jinshui , Zhan Liang , Ma Lulu , Fang Zheyu , Vajtai Robert , Wang Xinchen , Ajayan Pulickel M.
Published: July 2013

Free‐standing graphitic C3N4 nanosheets are prepared by liquid phase exfoliation from graphitic C3N4 powders dispersed in various solvents such as isopropanol, N‐methylpyrrolidone, water, ethanol, or acetone (sonication for 10 h).
ChemInform Abstract: One‐dimensional Nanostructures by Pulsed Laser Ablation
Authors: Yang Rusen
Published: July 2013

Review: 52 refs.
ChemInform Abstract: Electroless Nickel, Alloy, Composite and Nano Coatings — A Critical Review
Authors: Sudagar Jothi , Lian Jianshe , Sha Wei
Published: July 2013

Review: 219 refs.
ChemInform Abstract: Synthesis of Rare Earth Nanomaterials
Authors: Yan Chun‐Hua , Zhang Chao , Sun Ling‐Dong
Published: July 2013

Review: 207 refs.
ChemInform Abstract: A Perspective on Free Radical Autoxidation: The Physical Organic Chemistry of Polyunsaturated Fatty Acid and Sterol Peroxidation
Authors: Porter Ned A.
Published: July 2013

Review: 134 refs.
ChemInform Abstract: Hydrolysis of Cellulose to Glucose by Solid Acid Catalysts.
Authors: Huang Yao‐Bing , Fu Yao
Published: July 2013

Review: [119 refs.]
ChemInform Abstract: Asymmetric Induction in Reactions Catalyzed by Metal Complexes
Authors: Pavlov V. A. , Pavlova T. N.
Published: July 2013

Review: 287 refs.
ChemInform Abstract: Solid Superbase Catalysts Developed in the Past Two Decades
Authors: Chen Lang , Zhao Jin , Yin Shuang‐Feng , Au Chak‐Tong
Published: July 2013

Review: 79 refs.
ChemInform Abstract: Reduction: Hydrosilylation
Authors: Nishiyama H.
Published: July 2013

Review: 74 refs.
ChemInform Abstract: Supramolecular Chemistry of Fullerenes on Solid Surfaces
Authors: Otero Roberto , Gallego Jose Maria , Martin Nazario , Miranda Rodolfo
Published: July 2013

Review: 72 refs.
ChemInform Abstract: Oligonucleotide—Carbohydrate Conjugates
Authors: Spinelli Nicolas , Defrancq Eric
Published: July 2013

Review: 84 refs.
ChemInform Abstract: Multivalent Glycocalixarenes
Authors: Sansone Francesco , Rispoli Gabriele , Casnati Alessandro , Ungaro Rocco
Published: July 2013

Review: 72 refs.
ChemInform Abstract: Enzymatic Carbohydrate Synthesis
Authors: Flitsch S. L.
Published: July 2013

Review: 50 refs.
ChemInform Abstract: Enzyme‐Catalyzed Aldol Additions
Authors: Clapes Pere , Joglar Jesus
Published: July 2013

Review: 163 refs.
ChemInform Abstract: Supersilyl Protective Groups in Aldol Reactions
Authors: Brady Patrick B. , Yamamoto Hisashi
Published: July 2013

Review: 99 refs.
ChemInform Abstract: Stereoselective Acetate Aldol Reactions
Authors: Romea Pedro , Urpi Felix
Published: July 2013

Review: 471 refs.
ChemInform Abstract: Hydrogenation and Transfer Hydrogenation in Water
Authors: Wu Xiaofeng , Xiao Jianliang
Published: July 2013

Review: 346 refs.
ChemInform Abstract: A Dipolar Cycloaddition Strategy for the Synthesis of 3,8‐Diazabicyclo[3.2.1]octane Tetrahydroisoquinoline Antitumor Antibiotics. The Total Synthesis of (‐)‐Lemonomycin
Authors: Ashley Eric , Stoltz Brian
Published: July 2013

Review: 60 refs.
ChemInform Abstract: Terpene‐Derived Auxiliaries: Camphor‐ and Pinene‐Derived Auxiliaries
Authors: Cody J. A. , Boeckman R. K. Jr.
Published: July 2013

Review: 145 refs.
ChemInform Abstract: Selected Diastereoselective Reactions. Diastereoface‐differentiating Claisen, Cope, and [2,3]‐Wittig Rearrangements in Contemporary Natural Product Synthesis
Authors: Hiersemann M. , Jaschinski T.
Published: July 2013

Review: 93 refs.
ChemInform Abstract: Selected Diastereoselective Reactions. Diastereoselective Intra‐ and Intermolecular 1,3‐Dipolar Cycloadditions in Natural Product Synthesis
Authors: Mulzer J.
Published: July 2013

Review: 131 refs.
ChemInform Abstract: Anion Capture and Sensing with Cationic Boranes: Synergy of Coulombic Effects and Onium Ion Centered Lewis Acidity
Authors: Zhao Haiyan , Leamer Lauren A. , Gabbai Francois P.
Published: July 2013

Review: 158 refs.
ChemInform Abstract: Nonthermal Effects of Microwaves in Organic Synthesis
Authors: Perreux Laurence , Loupy Andre , Petit Alain
Published: July 2013

Review: 228 refs.
ChemInform Abstract: Atom Substitution Effects in Ionic Liquids: A Microscopic View by Femtosecond Raman‐Induced Kerr Effect Spectroscopy
Authors: Shirota Hideaki , Fukazawa Hiroki
Published: July 2013

Review: 78 refs.
ChemInform Abstract: Dynamic Heterogeneity in Room‐Temperature Ionic Liquids
Authors: Jeong Daun , Kim Daekeon , Choi M. Y. , Kim Hyung J. , Jung Youn Joon
Published: July 2013

Review: 63 refs.
ChemInform Abstract: Physico‐Chemical Properties of Task‐Specific Ionic Liquids
Authors: Branco Luis C. , Carrera Goncalo V. S. M. , Aires‐de‐Sousa Joao , Martin Ignacio Lopez , Frade Raquel , Afonso Carlos A. M.
Published: July 2013

Review: 179 refs.
ChemInform Abstract: Expanding Coordination Chemistry from Protein to Protein Assembly
Authors: Sanghamitra Nusrat J. M. , Ueno Takafumi
Published: July 2013

Review: 111 refs.
NLO Response of Photoswitchable Azobenzene‐Based Materials
Authors: Liaros Nikolaos , Couris Stelios , Maggini Laura , De Leo Federica , Cattaruzza Fabrizio , Aurisicchio Claudia , Bonifazi Davide
Published: July 2013

The nonlinear optical (NLO) response of three π‐conjugated azobenzene (AB) derivatives was investigated under picosecond laser excitation by means of the Z‐scan technique to evaluate the effect of an ethynyl‐based conjugated spacer on the NLO properties of ABs. All modules possessed large third‐order nonlinearity, but unexpectedly it was the less extended AB derivative that exhibited the largest NLO response. This finding has been confirmed by means of DFT calculations and was attributed to a higher cis/trans ratio of the particular AB derivative in its investigated photoequilibrated state. Furthermore, the influence of the amount of cis isomer on the third‐order nonlinear susceptibility [χ(3)] of the less extended AB derivative has been thoroughly investigated. Specifically, modulation of the NLO response has been successfully achieved by tuning the isomeric composition of the investigated photostationary state. These results highlighted the cis‐dependent increase of the NLO response to support the general idea that such compounds can be used for multistep switching NLO materials.
The Microbiome as a Therapeutic Target for Metabolic Diseases
Authors: Rajpal Deepak K. , Brown James R.
Published: July 2013

Preclinical Research

Metabolic diseases, especially type 2 diabetes and obesity, are growing global health‐care concerns. New therapeutic approaches are urgently needed to address the emerging epidemic of obesity and diabetes. Recent studies have highlighted the role of gastrointestinal microbial communities in metabolic health and disease. The microbiome, the collective genomic and metabolic potential of the gut microbiota, may have a key role in many chronic diseases through its mitigation of immune‐inflammatory responses. Here we provide an overview of present knowledge about the gut microbiome, its putative role in metabolic diseases and the potential for microbiome focused treatments involving either modulation of the microbial ecosystem or influencing microbiota–human host cross‐talk pathways.
Psychopathy's influence on the coupling between hypothalamic–pituitary–adrenal and ‐gonadal axes among incarcerated adolescents
Authors: Johnson Megan M. , Dismukes Andrew R. , Vitacco Michael J. , Breiman Chelsea , Fleury Donald , Shirtcliff Elizabeth A.
Published: July 2013

Conduct disorder (CD) is a heterogeneous diagnosis, leading researchers to initiate studies focused on neurobiological mechanisms underlying this disorder. One specifier of CD currently considered for inclusion in the DSM‐V is callous‐unemotional (CU) traits, a key component of psychopathy. CU traits are thought to have neuroendocrine underpinnings, yet little is known about hypothalamic–pituitary–adrenal (HPA) and ‐gonadal (HPG) hormones in the context of psychopathic traits. The current study sought to identify daily coupling patterns between HPA and HPG hormones in order to clarify distinct neurobiological underpinning associated with psychopathic/CU traits. Fifty incarcerated adolescent males who met criteria for CD were recruited and provided 10 saliva samples across 2 days. Participants completed the Psychopathy Checklist Youth Version (PCL:YV) and Inventory of Callous Unemotional Traits (ICU) on a third day. Diurnal cortisol, testosterone, and DHEA functioning was modeled via hierarchical linear modeling. Psychopathy subscales from the measures administered were used as predictors of daily coupling patterns between these hormones. Results indicated all three hormones were tightly coupled. Further, higher PCL‐YV interpersonal scores related to greater coupling between all three hormones, whereas higher ICU callousness scores related to greater uncoupling of testosterone with cortisol and DHEA. The current study is novel in its emphasis on testing the coupling of HPA and HPG hormones among incarcerated adolescent males. Results suggest that affective and interpersonal psychopathic traits are marked by unique HPA‐ and HPG coupling. © 2013 Wiley Periodicals, Inc. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 448–458, 2014.
Patterns of hemispheric specialization for a communicative gesture in different primate species
Authors: Meunier Hélène , Fagard Jacqueline , Maugard Anaïs , Briseño Margarita , Fizet Jonas , Canteloup Charlotte , Defolie Charlotte , Vauclair Jacques
Published: July 2013

We review four studies investigating hand preferences for grasping versus pointing to objects at several spatial positions in human infants and three species of nonhuman primates using the same experimental setup. We expected that human infants and nonhuman primates present a comparable difference in their pattern of laterality according to tasks. We tested 6 capuchins, 6 macaques, 12 baboons, and 10 human infants. Those studies are the first of their kind to examine both human infants and nonhuman primate species with the same communicative task. Our results show remarkable convergence in the distribution of hand biases of human infants, baboons and macaques on the two kinds of tasks and an interesting divergence between capuchins' and other species' hand preferences in the pointing task. They support the hypothesis that left‐lateralized language may be derived from a gestural communication system that was present in the common ancestor of macaques, baboons and humans. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 55: 662–671, 2013.
Inhaled corticosteroids for cystic fibrosis—are they worth the risk?
Authors: Robinson Joan
Published: July 2013

Eco‐paediatrics is an occasional feature in Evidence‐Based Child Health: A Cochrane Review Journal. Our goal is to contribute to the worldwide discussion on reducing waste in health care. In each instalment, we will select a recent Cochrane review highlighting a practice, still in use, which the available evidence tells us should be discontinued.
Tuning Oxyquinolate Non‐Innocence at the Ruthenium Polypyridyl Core
Authors: Zhao Helen C. , Fu Bi‐Li , Schweinfurth David , Harney Joseph P. , Sarkar Biprajit , Tsai Ming‐Kang , Rochford Jonathan
Published: July 2013

The electronic structure of [Ru(bpy)2(OQN)]+ (where bpy = 2,2′‐bipyridine and OQN = 8‐oxyquinolate) has been revisited using a complimentary suite of theoretical (DFT/TD‐DFT), electrochemical (cyclic voltammetry) and spectroscopic techniques (UV/Vis/NIR absorption, EPR spectroscopy). Through functionalization of the R‐OQN ligand (R = 2‐Me; 5,7‐Me2; 5‐F; 5‐Cl; 5,7‐Cl2; 5‐NO2) charge delocalization across the non‐innocent ruthenium‐oxyquinolate framework has been investigated and correlated with substituent Hammett parameters. Combined spectroscopic and computational studies indicate substantial mixing at the HOMO–3, HOMO and LUMO+2 levels between the Ru and R‐OQN π‐systems allowing controlled tuning of complex redox potentials while maintaining panchromatic absorption characteristics. UV/Vis/NIR and EPR spectroelectrochemical data is reported which shows strong evidence for substituent dependence of hole delocalization onto the R‐OQN ligand following one‐electron oxidation of the hybrid Ru(R‐OQN) based HOMO level. EPR data correlates very well with Mulliken spin‐density calculations confirming non‐innocence of the R‐OQN ligand which allows control of spin‐distribution across the Ru(R‐OQN) π‐system
Divergent Synthesis of α,α‐Dihaloamides through α,α‐Dihalogenation of β‐Oxo Amides by Using N‐Halosuccinimides
Authors: Wang Jia , Li Hongtao , Zhang Dingyuan , Huang Peng , Wang Zikun , Zhang Rui , Liang Yongjiu , Dong Dewen
Published: July 2013

An efficient and divergent one‐pot synthesis of α,α‐dihaloamides from readily available β‐oxo amides based on the selection of reaction conditions is reported. α,α‐Dihalo‐β‐oxo amides were produced by treating β‐oxo amides with N‐chlorosuccinimide (NCS) or N‐bromosuccinimide (NBS) in water at room temperature, whereas α,α‐dihaloacetamides were synthesized by subjecting β‐oxo amides to NCS or NBS in ethanol under reflux.
A Divergent Method to Prepare 5‐Amino‐, 5‐N‐Acetamido‐, and 5‐N‐Glycolylsialosides
Authors: Boltje Thomas J. , Heise Torben , Rutjes Floris P. J. T. , van Delft Floris L.
Published: July 2013

Sialic acids are essential mediators of biological processes involving carbohydrate recognition. A major determinant of sialic acid recognition is the N‐5 substituent, which can be an N‐acetyl (human), N‐glycolyl (non‐human), or amine (cancer associated) functionality. Access to homogeneous sialosides with distinct substitution patterns is essential to determine structure–activity relationships. Herein, we report a divergent chemical approach to enable the synthesis of a library of specifically substituted sialosides by using a single sialic acid building block.
Review on Recent Progress on Sandwich‐Structure Hybrid Solar Cells
Authors: Chen Hsin‐Yi , Kao Shao‐Hsuan , Lin Ching‐Fuh
Published: July 2013

We review the recent developments and techniques applied to hybrid solar cells. Hybrid solar cells have progressed rapidly in the past few years. The highest efficiency of hybrid solar cells has exceeded 10 %, meeting the commercial requirement for production. In addition, their stability has been improved significantly using sandwiched structures with the enormous achievement of retaining their efficiency within 95 % of the maximum value after 4800 h in air without encapsulation. The synthesis of new organic photoactive materials has helped to induce high efficiencies, and new designs for the device structure have led to enhanced stability, which has been a major factor in enabling such significant progress in hybrid solar cells. The latest advances and achievements for hybrid solar cells will be reviewed in this paper.
Psychological Factors Predict Eating Disorder Onset and Maintenance at 10‐year Follow‐up
Authors: Holland Lauren A. , Bodell Lindsay P. , Keel Pamela K.
Published: July 2013

The present study sought to identify psychological factors that predict onset and maintenance of eating disorders. Secondary analyses were conducted using data from an epidemiological study of health and eating behaviours in men and women (N = 1320; 72% female) to examine the prospective and independent influence of the Eating Disorder Inventory Perfectionism, Interpersonal Distrust, and Maturity Fears subscales in predicting the onset and maintenance of eating disorders at 10‐year follow‐up. Multivariate models indicated higher Perfectionism (p = .025), lower Interpersonal Distrust (p < .001), and higher Maturity Fears (p = .037) predicted increased risk for eating disorder onset at 10‐year follow‐up, but only Perfectionism (p = .004) predicted eating disorder maintenance. Differential prediction of eating disorder onset versus maintenance highlights potentially different psychological foci for prevention versus treatment efforts. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
Improving phasor data concentrators reliability for smart grid
Authors: Chen Zhi , Qiu Meikang , Zhu Yongxin , Qin Xiao , Quan Gang
Published: July 2013

Phasor data concentrators (PDCs) are the critical components of a wide area monitoring system (WAMS) in the smart grid. They are multi‐processor devices employed to collect, concentrate, and synchronize phasor data that is from various phasor measurement units and from other PDCs. Because of their present significance and potential criticality for WAMS, reliability of PDCs has become a high priority problem. In this paper, we first formally model the reliability problem on PDCs. Then, we propose a novel task scheduling algorithm, two‐phase heuristic task scheduling, to enhance the reliability of a PDC with real‐time constraints of applications. This algorithm seamlessly integrates both tasks scheduling and reliability optimization techniques via appropriately allocate and reallocate tasks to different processors of PDCs. Experimental results show that the proposed algorithm can efficiently guarantee reliability for PDCs with real‐time constraints. Copyright © 2013 John Wiley & Sons, Ltd.
Model fire tests on a beam‐to‐leg connection in an offshore platform topside
Authors: Hosseini S. A. , Zeinoddini M. , Saedi Daryan A. , Rahbari M.
Published: July 2013

Beam‐to‐column connections are of great significance as they noticeably influence the mechanical behavior of structures at ambient and elevated temperatures. Observations from full‐scale fire tests confirm that connections play an important role on the resistance time of structural components in fire. Because of the high cost of elevated temperature tests, adequate experimental data on a broad range of connections are not available. One type of such connections is the I‐beam‐to‐circular tubular leg connections in offshore oil/gas platform topsides. Considering the high risk of fire events in offshore oil/gas platforms, our study focuses on the structural behavior of this type of connection at elevated temperatures. Eleven small‐scale experimental tests were conducted on a uniplanar welded steel I‐beam‐to‐tubular chord connection with external diaphragms to investigate their fire resistance capacity. Local strengthening and partial thermal insulating were separately introduced to the connection components. The results show that the external diaphragms play a considerably more important role on the connection fire response as compared with that for the vertical stiffeners. It is also found that the degradations in the connections' stiffness at elevated temperature might be closely correlated with the classical thermomechanical data on steel material. Copyright © 2013 John Wiley & Sons, Ltd.
Noisy Inventory Announcements and Energy Prices
Authors: Halova Marketa W. , Kurov Alexander , Kucher Oleg
Published: July 2013

This study examines the effect of oil and gas inventory announcements on energy prices. Previous estimates of this effect suffer from bias due to measurement error in inventory surprises. We utilize intraday futures data for three petroleum commodities and natural gas to estimate the price response coefficients using traditional event study regressions and the identification‐through‐censoring (ITC) technique proposed by Rigobon and Sack [Rigobon and Sack (2008). Asset prices and monetary policy (pp. 335–370). Chicago: University of Chicago Press]. The results show that the bias in OLS estimates of the price impact of inventory surprises is quite large. The ITC coefficient estimates are about twice as large as OLS estimates for petroleum commodities and about four times as large as OLS estimates for natural gas. These results imply that energy prices are more strongly influenced by unexpected changes in inventory than shown in previous research. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark 34:911–933, 2014
Regional variations in vascular density correlate with resting‐state and task‐evoked blood oxygen level‐dependent signal amplitude
Authors: Vigneau‐Roy Nicolas , Bernier Michaël , Descoteaux Maxime , Whittingstall Kevin
Published: July 2013

Functional magnetic resonance imaging (fMRI) has become one of the primary tools used for noninvasively measuring brain activity in humans. For the most part, the blood oxygen level‐dependent (BOLD) contrast is used, which reflects the changes in hemodynamics associated with active brain tissue. The main advantage of the BOLD signal is that it is relatively easy to measure and thus is often used as a proxy for comparing brain function across population groups (i.e., control vs. patient). However, it is particularly weighted toward veins whose structural architecture is known to vary considerably across the brain. This makes it difficult to interpret whether differences in BOLD between cortical areas reflect true differences in neural activity or vascular structure. We therefore investigated how regional variations of vascular density (VAD) relate to the amplitude of resting‐state and task‐evoked BOLD signals. To address this issue, we first developed an automated method for segmenting veins in images acquired with susceptibility‐weighted imaging, allowing us to visualize the venous vascular tree across the brain. In 19 healthy subjects, we then applied voxel‐based morphometry (VBM) to T1‐weighted images and computed regional measures of gray matter density (GMD). We found that, independent of spatial scale, regional variations in resting‐state and task‐evoked fMRI amplitudes were better correlated to VAD compared to GMD. Using a general linear model (GLM), it was observed that the bulk of regional variance in resting‐state activity could be modeled by VAD. Cortical areas whose resting‐state activity was most suppressed by VAD correction included Cuneus, Precuneus, Culmen, and BA 9, 10, and 47. Taken together, our results suggest that resting‐state BOLD signals are significantly related to the underlying structure of the brain vascular system. Calibrating resting BOLD activity by venous structure may result in a more accurate interpretation of differences observed between cortical areas and/or individuals. Hum Brain Mapp 35:1906–1920, 2014. © 2013 Wiley Periodicals, Inc.
Fast neutron radiotherapy for primary mucosal melanomas of the head and neck
Authors: Liao Jay J. , Parvathaneni Upendra , Laramore George E. , Thompson John A. , Bhatia Shailender , Futran Neal D. , Bhrany Amit D. , Hawes Stephen E. , Ladra Matthew
Published: July 2013

Background

Primary head and neck mucosal melanomas (HNMMs) are rare tumors managed with surgery and/or radiotherapy and associated with poor outcomes. Given their radioresistance, high linear energy transfer radiotherapy with neutrons may improve local control.

Methods

We conducted a retrospective review of 14 patients with HNMM treated with neutrons at the University of Washington from 1990 to 2012. Five patients had T3 disease, 9 had T4 disease, 3 had regional nodal disease, and 4 had distant metastases at diagnosis. Primary sites were sinonasal (n=10), lip (n=2), and palate (n=2). Ten patients had initial surgical resection/debulking.

Results

Nine patients had gross residual disease, 6 had complete response, and 3 had partial response. Local control was achieved in 79% until death or last follow‐up, and 50% developed distant metastases. Kaplan–Meier 5‐year local control was 66% and overall survival was 21%.

Conclusion

High rates of locoregional control were achieved with neutrons, despite the presence of gross disease. Survival was limited by early distant metastases. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1162–1167, 2014
Randomized, double-blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy
Authors: Rockey Don C. , Vierling John M. , Mantry Parvez , Ghabril Marwan , Brown Robert S. , Alexeeva Olga , Zupanets Igor A. , Grinevich Vladimir , Baranovsky Andrey , Dudar Larysa , Fadieienko Galyna , Kharchenko Nataliya , Klaryts'ka Iryna , Morozov Vyacheslav , Grewal Priya , McCashland Timothy , Reddy Gautham K. , Reddy Rajender K. , Syplyviy Vasyl , Bass Nathan M. , Dickinson Klara , Norris Catherine , Coakley Dion , Mokhtarani Masoud , Scharschmidt Bruce F.
Published: July 2013

Glycerol phenylbutyrate (GPB) lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion in the form of phenylacetyl glutamine, which is excreted in urine. This randomized, double-blind, placebo-controlled phase II trial enrolled 178 patients with cirrhosis, including 59 already taking rifaximin, who had experienced two or more hepatic encephalopathy (HE) events in the previous 6 months. The primary endpoint was the proportion of patients with HE events. Other endpoints included the time to first event, total number of events, HE hospitalizations, symptomatic days, and safety. GPB, at 6 mL orally twice-daily, significantly reduced the proportion of patients who experienced an HE event (21% versus 36%; P = 0.02), time to first event (hazard ratio [HR] = 0.56; P < 0.05), as well as total events (35 versus 57; P = 0.04), and was associated with fewer HE hospitalizations (13 versus 25; P = 0.06). Among patients not on rifaximin at enrollment, GPB reduced the proportion of patients with an HE event (10% versus 32%; P < 0.01), time to first event (HR = 0.29; P < 0.01), and total events (7 versus 31; P < 0.01). Plasma ammonia was significantly lower in patients on GPB and correlated with HE events when measured either at baseline or during the study. A similar proportion of patients in the GPB (79%) and placebo groups (76%) experienced adverse events. Conclusion: GPB reduced HE events as well as ammonia in patients with cirrhosis and HE and its safety profile was similar to placebo. The findings implicate ammonia in the pathogenesis of HE and suggest that GPB has therapeutic potential in this population. (Clinicaltrials.gov, NCT00999167). (HEPATOLOGY 2014;59:1073-1083)
Study on the Mechanism of Formation of 1‐Methylheptyl Phenyl Ether by the Isourea Method
Authors: Cuny Eckehard , Jaeger Rolf
Published: July 2013

The formation of (1R)‐1‐methylheptyl phenyl ether from (2S)‐octan‐2‐ol via its isourea derivative (S)‐1 follows a borderline mechanism. The intermediacy of a carbocation (see (S)‐2) can be demonstrated (Scheme 1). However, the extremely high inversion of configuration and the olefinic by‐products are also indicative of an SN2 mechanism.
Oligonucleotide Analogues with Integrated Bases and Backbone. Part 30
Authors: Herdeis Lorenz , Thomas Siji , Bernet Bruno , Vasella Andrea
Published: July 2013

The protected G*[s]C*[s]U*[s]A*[s]U*[s]A*[s]G*[s]C* octanucleoside 24 was prepared by S‐alkylation of the thiolate derived from tetranucleoside 23 with the methanesulfonate 22, and transformed to the silylated and isopropylidenated 25, and further into the fully deprotected octanucleoside 26. Compound 22 was derived from the methoxytrityl‐protected tetranucleoside 21, and 21 was obtained by S‐alkylation of the thiolate derived from the dinucleoside 19 with methanesulfonate 17 derived from 16 by detritylation and mesylation. Similarly, tetranucleoside 23 resulted from S‐alkylation of the thiolate derived from 18 with the methanesulfonate 20 derived from 19. Dinucleosides 16 and 18 resulted from S‐alkylation of the thiolate derived from the known cytidine‐derived thioacetate 15 with the C(8)‐substituted guanosine‐derived methanesulfonates 12 and 14, respectively, that were synthesized from the protected precursors 4 and 7 by formylation, reduction, protection, and mesylation.

The structures of the duplexes of 25 and 26 were calculated using AMBER* modelling and based on the known structure of the core tetranucleoside U*[s]A*[s]U*[s]A*. The former shows a helix with a bent helix axis and strong buckle and propeller twists, whereas the latter is a regular, right‐handed, and apparently strain‐free helix. In agreement with modelling, the silylated and isopropylidenated octanucleoside 25 in (CDCl2)2 solution led to a mixture of associated species possessing at most four WatsonCrick base pairs, while the fully deprotected octanucleoside 26 in aqueous medium forms a duplex, as evidenced by a decreasing CD absorption upon increasing the temperature and by a UV‐melting curve with a melting temperature of ca. 10° below the one of the corresponding RNA octamer, indicating cooperativity between base pairing and base‐pair stacking.
I Remember When You Taught Me That! Preschool Children's Memories of Realistic Learning Episodes
Authors: Bemis Rhyannon H. , Leichtman Michelle D. , Pillemer David B.
Published: July 2013

This study examined whether preschool children are able to identify the source of new knowledge that they acquired in a stimulating, interactive learning context. Sixty 4‐ to 5‐year‐old children participated in two staged learning events. Several days later, children were asked questions that assessed their knowledge of factual information presented during the events. Children indicated whether they knew the answer to each question and whether they remembered the moment they learned it (i.e. had an episodic memory of the learning event), and then recalled event details. A majority of preschoolers were able to accurately identify how they had learned at least some factual information, but this ability was not consistent across children and test items. Recall of event‐specific details was positively correlated with correct answers to factual questions. The results indicate that when preschool children are asked to reflect on past learning experiences that occurred in complex and realistic contexts, their source monitoring abilities are evident but not yet fully developed. Copyright © 2013 John Wiley & Sons, Ltd.
Axin: An emerging key scaffold at the synapse
Authors: Chen Yu , Fu Amy K.Y. , Ip Nancy Y.
Published: July 2013

Neurons communicate through neurotransmission at the synapse. Precise regulation of the synaptic structure and signaling during the formation and remodeling of synapses is vital for information processing between neurons. Scaffold proteins play key roles in synapses by tethering the signaling cascades spatially and temporally to ensure proper brain functioning. This review summarizes the recent evidence indicating that Axin, a scaffold protein, plays a central role in orchestrating presynaptic and postsynaptic signaling complexes to regulate synapse development and plasticity in the central nervous system. © 2013 IUBMB Life, 65(8):685–691, 2013.
Evaluation of hemocompatibility and endothelialization of hybrid poly(vinyl alcohol) (PVA)/gelatin polymer films
Authors: Ino Julia M. , Sju Ervi , Ollivier Véronique , Yim Evelyn K.F. , Letourneur Didier , Le Visage Catherine
Published: July 2013

Engineered grafts are still needed for small diameter blood vessels reconstruction. Ideal materials would prevent thrombosis and intimal hyperplasia by displaying hemocompatibility and mechanical properties close to those of native vessels. In this study, poly(vinyl alcohol) (PVA)/gelatin blends were investigated as a potential vascular support scaffold. We modified a chemically crosslinked PVA hydrogel by incorporation of gelatin to improve endothelial cell attachment with a single‐step method. A series of crosslinked PVA/gelatin films with specific ratios set at 100:0, 99:1, 95:5, and 90:10 (w/w) were prepared and their mechanical properties were examined by uniaxial tensile testing. Tubes, obtained from sutured films, were found highly compliant (3.1–4.6%) and exhibited sufficient mechanical strength to sustain hemodynamic strains. PVA‐based hydrogels maintained low level of platelet adhesion and low thrombogenic potential. Endothelial cell adhesion and proliferation were drastically improved on PVA/gelatin films with a feed gelatin content as low as 1% (w/w), leading to the formation of a confluent endothelium. Hydrogels with higher gelatin content did not sustain complete endothelialization because of modifications of the film surface, including phase segregation and formation of microdomains. Thus, PVA/gelatin (99:1, w/w) hydrogels appear as promising materials for the design of endothelialized vascular materials with long‐term patency. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1549–1559, 2013.