bluuebunny/crossref_metadata_2025 huggingface dataset:
Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors
Authors: Gibb Fraser W , Dixon J Michael , Clarke Catriona , Homer Natalie Z , Faqehi Abdullah M M , Andrew Ruth , Walker Brian R
Published: March 2019

Context

Aromatase deficiency causes obesity and insulin resistance in aromatase knockout mice and humans with rare mutations of the aromatase gene (CYP19). Aromatase inhibitors are a commonly prescribed therapy for postmenopausal breast cancer.

Objective

We hypothesized that aromatase inhibitors induce obesity and insulin resistance when used in treatment of breast cancer.

Design

Case-control study.

Setting

University teaching hospital.

Participants

Patients with postmenopausal breast cancer (n = 20) treated with aromatase inhibitors and 20 age-matched control subjects.

Main outcome measures

The primary outcome measure was insulin sensitivity index – Matsuda, derived from a 75-g oral glucose tolerance test. Body composition was assessed by dual energy x-ray absorptiometry and biopsy specimens of subcutaneous adipose tissue obtained for assessment of mRNA transcript levels. Data are reported as mean ± SEM (patients receiving inhibitors vs control group, respectively).

Results

Aromatase inhibitor therapy was associated with significantly lower insulin sensitivity (5.15 ± 0.45 vs 6.80 ± 0.64; P = 0.041), higher peak insulin concentration after oral glucose tolerance test (693.4 ± 78.6 vs 527.6 ± 85.5 pmol/L; P = 0.035), greater percentage of body fat (38.4% ± 1.0% vs 34.6% ± 1.3%; P = 0.026), and higher plasma leptin concentration (23.5 ± 2.8 vs 15.5 ± 2.3 ng/mL; P = 0.035).

Conclusion

Women who received aromatase inhibitors for postmenopausal breast cancer had greater percentage body fat and insulin resistance compared with control subjects with no history of breast cancer.
Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data
Authors: Levie Deborah , Korevaar Tim I M , Bath Sarah C , Murcia Mario , Dineva Mariana , Llop Sabrina , Espada Mercedes , van Herwaarden Antonius E , de Rijke Yolanda B , Ibarluzea Jesús M , Sunyer Jordi , Tiemeier Henning , Rayman Margaret P , Guxens Mònica , Peeters Robin P
Published: March 2019

Context

Although the consequences of severe iodine deficiency are beyond doubt, the effects of mild to moderate iodine deficiency in pregnancy on child neurodevelopment are less well established.

Objective

To study the association between maternal iodine status during pregnancy and child IQ and identify vulnerable time windows of exposure to suboptimal iodine availability.

Design

Meta-analysis of individual participant data from three prospective population-based birth cohorts: Generation R (Netherlands), INMA (Spain), and ALSPAC (United Kingdom); pregnant women were enrolled between 2002 and 2006, 2003 and 2008, and 1990 and 1992, respectively.

Setting

General community.

Participants

6180 mother-child pairs with measures of urinary iodine and creatinine concentrations in pregnancy and child IQ. Exclusion criteria were multiple pregnancies, fertility treatment, medication affecting the thyroid, and preexisting thyroid disease.

Main Outcome Measure

Child nonverbal and verbal IQ assessed at 1.5 to 8 years of age.

Results

There was a positive curvilinear association of urinary iodine/creatinine ratio (UI/Creat) with mean verbal IQ only. UI/Creat <150 µg/g was not associated with lower nonverbal IQ (−0.6 point; 95% CI: −1.7 to 0.4 points; P = 0.246) or lower verbal IQ (−0.6 point; 95% CI: −1.3 to 0.1 points; P = 0.082). Stratified analyses showed that the association of UI/Creat with verbal IQ was only present up to 14 weeks of gestation.

Conclusions

Fetal brain development is vulnerable to mild to moderate iodine deficiency, particularly in the first trimester. Our results show that potential randomized controlled trials investigating the effect of iodine supplementation in women with mild to moderate iodine deficiency on child neurodevelopment should begin supplementation not later than the first trimester.
Optimizing Management of Medically Responsive Epilepsy
Authors: Bauer Derek , Quigg Mark
Published: March 2019

PURPOSE OF REVIEW

This article reviews the management of patients with medically responsive epilepsy, including discussion of factors that may lead to transient breakthrough seizures and patient and physician strategies to maintain freedom from seizures.

RECENT FINDINGS

Imperfect adherence, unanticipated changes in ongoing medical therapy, inadvertent use of proconvulsants or concurrent medications that alter epilepsy medication kinetics, and a variety of seizure precipitants such as stress or sleep deprivation may alter long-term seizure control.

The majority of patients with epilepsy are medically responsive. Many potential factors may lead to breakthrough seizures in these patients. Identification of these factors, patient education, and use of self-management techniques including mindfulness therapy and cognitive-behavioral therapy may play a role in protecting patients with epilepsy against breakthrough seizures.
Nonepileptic Episodic Events
Authors: Hopp Jennifer L.
Published: March 2019

PURPOSE OF REVIEW

This review addresses the scope, evaluation, treatments, and outcomes of patients with nonepileptic episodic events with a focus on psychogenic nonepileptic seizures. Differentiation of the types of events, including a review of terminology, is included, as well as a brief review of special patient populations with these disorders.

RECENT FINDINGS

There are continued efforts to develop tools to improve the diagnosis of these disorders. A thorough evaluation with trained personnel and physicians knowledgeable in the assessment and treatment of these disorders is important. Although inpatient video-EEG monitoring in an epilepsy monitoring unit remains the gold standard for diagnosis, the assessment of clinical and historical factors is critical and can be useful in expediting the process and improving diagnostic certainty. International efforts have recently assisted in providing guidelines for the evaluation of the psychogenic disorders and may help target educational and other resources to underserved areas.

The prompt and accurate diagnosis of nonepileptic episodic events and psychogenic nonepileptic seizures is possible with current technology, and the appropriate and targeted use of evidence-based treatments may help improve patient quality of life and avoid unnecessary disability in patients with these disorders.
Update on Antiepileptic Drugs 2019
Authors: Abou-Khalil Bassel W.
Published: March 2019

PURPOSE OF REVIEW

This article is an update from the article on antiepileptic drug (AED) therapy published in the last Continuum issue on epilepsy and is intended to cover the vast majority of agents currently available to the neurologist in the management of patients with epilepsy. Treatment of epilepsy starts with AED monotherapy. Knowledge of the spectrum of efficacy, clinical pharmacology, and modes of use for individual AEDs is essential for optimal treatment for epilepsy. This article addresses AEDs individually, focusing on key pharmacokinetic characteristics, indications, and modes of use.

RECENT FINDINGS

Since the previous version of this article was published, three new AEDs, brivaracetam, cannabidiol, and stiripentol, have been approved by the US Food and Drug Administration (FDA), and ezogabine was removed from the market because of decreased use as a result of bluish skin pigmentation and concern over potential retinal toxicity.

Older AEDs are effective but have tolerability and pharmacokinetic disadvantages. Several newer AEDs have undergone comparative trials demonstrating efficacy equal to and tolerability at least equal to or better than older AEDs as first-line therapy. The list includes lamotrigine, oxcarbazepine, levetiracetam, topiramate, zonisamide, and lacosamide. Pregabalin was found to be less effective than lamotrigine. Lacosamide, pregabalin, and eslicarbazepine have undergone successful trials of conversion to monotherapy. Other newer AEDs with a variety of mechanisms of action are suitable for adjunctive therapy. Most recently, the FDA adopted a policy that a drug’s efficacy as adjunctive therapy in adults can be extrapolated to efficacy in monotherapy. In addition, efficacy in adults can be extrapolated for efficacy in children 4 years of age and older. Both extrapolations require data demonstrating that an AED has equivalent pharmacokinetics between its original approved use and its extrapolated use. In addition, the safety of the drug in pediatric patients has to be demonstrated in clinical studies that can be open label. Rational AED combinations should avoid AEDs with unfavorable pharmacokinetic interactions or pharmacodynamic interactions related to mechanism of action.

Knowledge of AED pharmacokinetics, efficacy, and tolerability profiles facilitates the choice of appropriate AED therapy for patients with epilepsy.
A gene expression atlas of embryonic neurogenesis in Drosophila reveals complex spatiotemporal regulation of lncRNAs
Authors: McCorkindale Alexandra L. , Wahle Philipp , Werner Sascha , Jungreis Irwin , Menzel Peter , Shukla Chinmay J. , Abreu Rúben Lopes Pereira , Irizarry Rafael A. , Meyer Irmtraud M. , Kellis Manolis , Zinzen Robert P.
Published: March 2019

Cell type specification during early nervous system development in Drosophila melanogaster requires precise regulation of gene expression in time and space. Resolving the programs driving neurogenesis has been a major challenge owing to the complexity and rapidity with which distinct cell populations arise. To resolve the cell type-specific gene expression dynamics in early nervous system development, we have sequenced the transcriptomes of purified neurogenic cell types across consecutive time points covering crucial events in neurogenesis. The resulting gene expression atlas comprises a detailed resource of global transcriptome dynamics that permits systematic analysis of how cells in the nervous system acquire distinct fates. We resolve known gene expression dynamics and uncover novel expression signatures for hundreds of genes among diverse neurogenic cell types, most of which remain unstudied. We also identified a set of conserved long noncoding RNAs (lncRNAs) that are regulated in a tissue-specific manner and exhibit spatiotemporal expression during neurogenesis with exquisite specificity. lncRNA expression is highly dynamic and demarcates specific subpopulations within neurogenic cell types. Our spatiotemporal transcriptome atlas provides a comprehensive resource for investigating the function of coding genes and noncoding RNAs during crucial stages of early neurogenesis.
Effect of Creatine Supplementation on the Airways of Youth Elite Soccer Players
Authors: SIMPSON ANDREW J. , HORNE SARA , SHARP PETER , SHARPS ROBERT , KIPPELEN PASCALE
Published: March 2019

Introduction

Owing to its well-established ergogenic potential, creatine is a highly popular food supplement in sports. As an oral supplement, creatine is considered safe and ethical. However, no data exist on the safety of creatine on lung function in athletes. The aim of this project was to evaluate the effects of a standard course of creatine on the airways of youth elite athletes.

Methods

Nineteen elite soccer players, 16–21 yr old, completed a stratified, randomized, double-blind, placebo-controlled, parallel-group trial. The creatine group (n = 9) ingested 0.3 g·kg−1⋅d−1 of creatine monohydrate (CM) for 1 wk (loading phase) and 5 g·d−1 for 7 wk (maintenance phase), and the placebo group (n = 10) received the same dosages of maltodextrin. Airway inflammation (assessed by exhaled nitric oxide, FENO) and airway responsiveness (to dry air hyperpnoea) were measured pre- and postsupplementation.

Results

Mild, unfavorable changes in FENO were noticed by trend over the supplementation period in the CM group only (P = 0.056 for interaction, η
2 = 0.199), with a mean group change of 9 ± 13 ppb in the CM group versus −5 ± 16 ppb in the placebo group (P = 0.056, d = 0.695). Further, the maximum fall in forced expiratory volume in 1 s after dry air hyperpnoea was larger by trend postsupplementation in the CM group compared with the placebo group: 9.7% ± 7.5% vs 4.4% ± 1.4%, respectively (P = 0.070, d = 0.975). These adverse effects were more pronounced when atopic players only (n = 15) were considered.

Conclusion

On the basis of the observed trends and medium to large effect sizes, we cannot exclude that creatine supplementation has an adverse effect on the airways of elite athletes, particularly in those with allergic sensitization. Further safety profiling of the ergogenic food supplement is warranted.
A Model of Safe Asset Determination
Authors: He Zhiguo , Krishnamurthy Arvind , Milbradt Konstantin
Published: March 2019

What makes an asset a “safe” asset? We study a model where two countries each issue sovereign bonds to satisfy investors’ safe asset demands. The countries differ in the float of their bonds and the fundamental resources available to rollover debts. A sovereign’s debt is safer if its fundamentals are strong relative to other possible safe assets, not merely strong on an absolute basis. If demand for safe assets is high, a large float enhances safety through a market depth benefit. If demand for safe assets is low, then large debt size is a negative as rollover risk looms large. (JEL F34, H63)
Assisted spatial navigation: new directions
Authors: Kostaki Maria , Vatakis Argiro , Samartzi Stavroula
Published: March 2019

Blockchain technology brings new possibilities in assisted spatial navigation. Decentralized map building enables collaboration between users around the world, while providing researchers with a common reference map for extending the capabilities of navigational systems towards more intuitive and accurate landmark navigation assistance. Research on landmark navigation has been mainly focused on the visual characteristics of landmarks. Human behavior, however, has systematically been shown to be enhanced in the presence of multisensory unified events. We propose, therefore, the enhancement of spatial assisted navigation by utilizing landmarks that are multisensory and semantically congruent. Further, our research will provide insights in terms of the auditory parameters that could be combined with a given visual landmark, so as to facilitate landmark retrieval algorithms and user satisfaction during assisted spatial navigation.
Improved inference of chromosome conformation from images of labeled loci
Authors: Ross Brian C. , Costello James C.
Published: March 2019

We previously published a method that infers chromosome conformation from images of fluorescently-tagged genomic loci, for the case when there are many loci labeled with each distinguishable color.  Here we build on our previous work and improve the reconstruction algorithm to address previous limitations.  We show that these improvements 1) increase the reconstruction accuracy and 2) allow the method to be used on large-scale problems involving several hundred labeled loci.  Simulations indicate that full-chromosome reconstructions at 1/2 Mb resolution are possible using existing labeling and imaging technologies.  The updated reconstruction code and the script files used for this paper are available at:  https://github.com/heltilda/align3d.
New insights emerge as antibody repertoire diversification meets chromosome conformation
Authors: Kenter Amy L. , Feeney Ann J.
Published: March 2019

Vast repertoires of unique antigen receptors are created in developing lymphocytes. The antigen receptor loci contain many variable (V), diversity (D), and joining (J) gene segments that are arrayed across very large genomic expanses and are joined to form variable-region exons. This process creates the potential for an organism to respond to large numbers of different pathogens. Here, we consider the underlying molecular mechanisms that favor some V genes for recombination prior to selection of the final antigen receptor repertoire. We discuss chromatin structures that form in antigen receptor loci to permit spatial proximity among the V, D, and J gene segments and how these relate to the generation of antigen receptor diversity.
INNOVATIONS AND SMALL BUSINESS: CURRENT SITUATION AND MODELING
Authors: Вилисов Валерий , Vilisov Valeriy , Вилисова Анна , Vilisova Anna
Published: March 2019

Presents an analysis of patterns and features innovative development factors and elements of innovation infrastructure in developed and developing economies of the world, including Russian. A set of mathematical economic models assessing the potential of innovative development of the economic entity. The technique of small enterprises transition to innovative development. For professionals in the field of innovation management, researchers, graduate students and doctoral candidates
Non-restorative cavity treatment: should this be the treatment of choice? reflections of a teacher in paediatric dentistry
Authors: Gruythuysen René JM
Published: March 2019

Non-Restorative Cavity Treatment (NRCT) is not favoured by many paediatric dentists. However, perhaps it should be the treatment of choice rather than confronting child and parents with a restorative, symptomatic, often less child-friendly approach. Does the child have a right to a viable biological treatment option, because solving a biological problem, basically caused by neglect, with technical solutions is ethically not defensible in all cases? Restorations simply mask the caries activity. What matters is the oral health and the well-being of the child. How can this best be served?

CPD/Clinical Relevance: This paper might serve as a discussion document for a group of oral health providers deciding practice policy with regard to the management of caries in primary teeth.
A review of additive manufacturing in conservative dentistry and endodontics part 2: applications in restorative dentistry and endodontics
Authors: Srinivas Peddi Shanmukh , Ashwini TS , Paras MG
Published: March 2019

The field of science and research is dynamic and the scientific disciplines of restorative dentistry and endodontics is no exception. The practice of dentistry and the technology involved has evolved hugely from the traditional to the contemporary. As a result of continual developments in technology, newer cutting edge methods in production and treatment have evolved. This paper explores the scope of additive manufacturing technology in restorative dentistry and endodontics, progress achieved in this field, practicality hurdles, and a promising future that this technology might provide if harnessed to its full potential.

CPD/Clinical Relevance: This paper gives an update on current concepts of additive manufacturing being employed in the field of restorative dentistry and endodontics for clinical practice, academic progress and translational research.
Management of intrabony defects in periodontal disease
Authors: Anderson William , Pye Andrew
Published: March 2019

Intrabony periodontal defects present a clinical challenge in the treatment of periodontal disease and maintenance of compromised teeth. The management of such defects ranges from non-surgical mechanical debridement to modern minimally invasive regenerative surgery. The incidence of intrabony defects is discussed along with prognosis and likely outcomes of various treatment options.

CPD/Clinical Relevance: Vertical or intrabony (IB) defects are a common occurrence in patients suffering from advanced periodontal disease. Primary care practitioners must be aware of possible treatment options in order to make suitable referrals when initial phases of treatment prove unsuccessful.
Amlodipine-induced gingival overgrowth in the peri-implant region: a review and case report
Authors: MacBeth Neil , Sterlitz Stephen , Bryce Graeme
Published: March 2019

Gingival overgrowth is a known side-effect of the antihypertensive drug amlodipine, but the risk of mucosal overgrowth around dental implants has been less well documented. This article discusses the role of calcium channel blockers in drug-induced mucosal overgrowth around dental implants and describes the preventive and surgical management of the case.

CPD/Clinical Relevance: The report describes the management of a patient with an implant-supported restoration who presented with peri-implantitis and drug-induced mucosal overgrowth. The review discusses how amlodipine and other medications, commonly associated with drug-induced gingival overgrowth, impact on the management of implant patients.
The bigger picture: a gorlin-goltz case report
Authors: Nimaa Zahra , Dubb Sukhpreet , Sharma Valmiki
Published: March 2019

Gorlin-Goltz is a multisystemic inherited disorder characterized by multiple oral and systemic manifestations. Although rare, it is important for the general dentist to be aware of this condition due to the presentation of multiple odontogenic keratocysts, and to understand the differential diagnoses of jaw radiolucencies. This case describes a 53-year-old Afro-Caribbean patient who was referred by his dentist to the Maxillofacial team at Queen's Hospital regarding a ‘strange sensation’ in the mouth. Upon further investigation it was found that he had Gorlin-Goltz syndrome.

CPD/Clinical Relevance: This article highlights the importance of looking at ‘the bigger picture’ clinically and radiographically and provides a reminder of the oral manifestations of Gorlin-Goltz syndrome and differential diagnoses of jaw radiolucencies.
Understanding the Systems, Contexts, Behaviors, and Strategies of Parents Advocating for Their Children With Down Syndrome
Authors: Krueger Kristen , Cless Jessica D. , Dyster Meghan , Reves Mollie , Steele Robert , Nelson Goff Briana S.
Published: March 2019

In the current qualitative research study, we focused on understanding the ecological systems, contexts, behaviors, and strategies of parents (N = 435) advocating for their children with an intellectual and developmental disability diagnosis, specifically Down syndrome (DS). Based on the data analysis, parents of children with DS advocate for their children frequently, in a variety of settings, with different actions, attitudes, motivations, and outcomes. The most common settings where advocacy occurred were primarily school and healthcare systems. The goals of parents often included inclusiveness, equality, and acceptance, whereas a few parents reported advocating due to discrimination and judgment. Implications for further research and professional practice also are described.
Fiscal Stewardship, Choice, and Control: The Context of Self-Directed Services for People With Intellectual and Developmental Disabilities (IDD) in the United States
Authors: Bogenschutz Matthew D. , DeCarlo Matthew , Hall-Lande Jennifer , Hewitt Amy
Published: March 2019

Self-directed home and community based services (HCBS) waiver services and supports for people with intellectual and developmental disabilities (IDD) have become a viable and widely used method of service provision in the United States. Grounded in theories of self-determination, previous literature on self-direction has suggested high satisfaction and positive outcomes for people who use self-directed programs as well as cost savings for state IDD service systems. This study explored the ways in which state IDD service administrators think about how self-direction may be used as a method of achieving cost savings while providing opportunities for people with IDD and their families to exercise choice and control. Informed by 54 high-level IDD service administrators in 34 states, and guided by a thematic analysis approach to data interpretation, the study found evidence that administrators typically see strong potential for self-direction to have cost-savings benefits, while also fostering choice. In the current political climate, the need for cautious fiscal stewardship may become a stronger driving force behind self-direction for people with IDD in the United States.
Between auteurism and sponsored cinema: Joris Ivens, Bernardo Bertolucci and ENI
Authors: Peretti Luca
Published: March 2019

Industrial and sponsored cinema played a pivotal role in film history, a role that has yet to be fully recognized in the study of Italian cinema. In Italy, the former state-owned oil company, Ente Nazionale Idrocarburi (National Hydrocarbons Authority) (ENI), sponsored films of different kinds, including two films made in the 1960s by major directors: the Dutch director Joris Ivens and the young but already-established Bernardo Bertolucci. By focusing on Ivens’ L’Italia non è un paese povero (Italy is not a Poor Country) (1960) and Bertolucci’s La via del petrolio (The Path of Oil) (1967) this article discusses the relationship between sponsored cinema and auteurism, and in particular how author theory (or ‘practice’) became important in Italian film studies and in the pioneering work of Millicent Marcus.
Voice and vision: The making of L’amore molesto (Troubling Love) by Mario Martone
Authors: Tabanelli Roberta
Published: March 2019

This article examines the adaptation of Mario Martone’s L’amore molesto (Troubling Love) (1995) as a successful case study in which the aesthetics of the cinematic medium (the ‘vision’) dominate over the verbal essence of the written page (the ‘voice’). Through a number of revisions of the screenplay Martone has achieved a finished product that is intrinsically ‘cinematic’ (i.e., dependant on images, sound, montage, camera angle, etc. to construct narrative and meaning). Particularly important in this cinematic distancing from the literary source was the progressive elimination of numerous voice-overs that Martone had planned in the earlier drafts of the script. Adaptation studies do not usually focus on the intermediate text between novel and film, the screenplay. However, my analysis of three drafts of the screenplay that Martone wrote for Troubling Love (one published and two unpublished) will demonstrate that such archival study can shed new light into the process of film writing and film adaptation.
Digital gleaning, feminist futures: Around Alina Marazzi’s Un’ora sola ti vorrei (For One More Hour with You) (2002)
Authors: Fabbri Lorenzo
Published: March 2019

This article situates Alina Marazzi’s Un’ora sola ti vorrei (For One More Hour with You) (2002) within the context of a larger preoccupation with memory and the archive in contemporary global media activism. Whereas Emma Wilson and Sara Filippelli have dwelled on the private dimension of the film, I argue that its labour of ‘digital gleaning’ – like Agnès Varda’s – seeks to save from decay, and allow to ripen, a past of feminist struggles. Taking up Millicent Marcus’s commitment to read together for film form and film politics, I focus on Marazzi’s use of editing and show how in this case montage is meant to assemble a new experience of national history. Through a comparative analysis of For One More Hour with You and Cecilia Mangini’s Essere donne (‘Being women’) (1964), I conclude that the peculiar interest of Marazzi’s film lies in the way it twins the history of the moving images and the trajectory of Italian society, conjuring in this way a different future for the nation and its cinema.
Poetry and place in Gorbaciof (Gorbaciof, The Cashier Who Liked Gambling) (Incerti, 2010) and Io sono Li (Shun Li and the Poet) (Segre, 2011)
Authors: Carolan Mary Ann McDonald
Published: March 2019

This article analyses a new trend in the representation of Chinese immigrants by Italian filmmakers, namely dramas such as Stefano Incerti’s Gorbaciof (Gorbaciof, The Cashier Who Liked Gambling) (2010) and Andrea Segre’s Io sono Li (Shun Li and the Poet) (2011) that recount friendships between older men and younger Chinese women. These narratives are inscribed in a larger conversation about race, migration and economics. The protagonists’ differences appear to confirm Europe’s fascination with the exotic East; the power imbalance between a mature European man and a youthful Asian woman further problematizes these relationships. while recognizing the possibilities for an Orientalist critique and the challenges of cross-cultural representation, this article argues that the filmmakers’ aesthetic choices – and their privileging of silence over dialogue – literally and figuratively attempt to bridge the gap between native and foreign, Italian and Chinese.
Identifying systemic creativity in Vince Gilligan’s Breaking Bad
Authors: Venkatasawmy Rama
Published: March 2019

This article considers Vince Gilligan’s highly innovative Breaking Bad (2008–13) as the outcome of a collaborative creative process shaped by the interaction between Gilligan, as the principal creative agent, with the evolving domain and field of American television. The innovativeness of Gilligan’s series is conceptualized here by means of applying Mihaly Csikszentmihalyi’s systems view of creativity, whereby Gilligan’s access to and impact on the domain of TV production is examined: he is seen as operating within the simultaneously constraining and enabling factors of the structures inherent to American television, its modes of production and viewership. This article elucidates how the innovativeness of Breaking Bad was the outcome of Gilligan’s adherence to and departure from particular traditions of form, format and structure inherent to the production of American TV drama – in conjunction with the radical transformations that the domain and field of American television were undergoing at the time.
Genital disc growth in Drosophila
Authors: Arias Carolina , Zapata Adriana , Ludueña-Almeida Francisco , Zacharonok Marcelo , Macías Ana
Published: March 2019

Prior to completion, apoptosis causes the secretion of different signals, including proliferative signals. Signaling associated with death was discovered in Drosophila and mostly characterized by the induction of experimental death. Thus, less is known about physiological death. Here, we analyzed physiological death in the genital disc, a structure with bilateral symmetry, in different growth scenarios. To this end, we prevented or promoted death in regions or in genetic mosaics. We observed that physiological death in the genital disc was associated with proliferative signals and that both processes were JNK-dependent. The proliferative signals promoted growth in the genitalia primordia but not in the analia. Due to the proliferative signaling, the prevention of death that produced undead cells provoked asymmetric growth, high variability in proliferation, and size reduction. Death can occur in the absence of JNK but without signaling. JNK is fundamental for growth and death associated with signaling.
Functional analysis of Arabidopsis and maize transgenic lines overexpressing the ADP-ribose/NADH pyrophosphohydrolase, AtNUDX7
Authors: Njuguna Elizabeth , Coussens Griet , Neyt Pia , Aesaert Stijn , Storme Veronique , Demuynck Kirin , Vanhaeren Hannes , Dhondt Stijn , Van Haver Yolaine , Paul Linus , Inzé Dirk , Nelissen Hilde , Van Lijsebettens Mieke
Published: March 2019

The conserved poly(ADP-ribosyl)ation (PAR) pathway consists of three genetic components that are potential targets to modulate the plant’s energy homeostasis upon stress with the aim to improve yield stability in crops and help secure food supply. We studied the role of the PAR pathway component ADP-ribose/NADH pyrophosphohydrolase (AtNUDX7) in yield and mild drought stress by using a transgenic approach in Arabidopsis thaliana and maize (Zea mays). Arabidopsis AtNUDX7 cDNA was overexpressed in Arabidopsis and maize by means of the constitutive Cauliflower Mosaic Virus 35S promoter and the strong constitutive Brachypodium distachyon pBdEF1α promoter, respectively. Overexpression of AtNUDX7 in Arabidopsis improved seed parameters that were measured by a novel, automated method, accelerated flowering and reduced inflorescence height. This combination of beneficial traits suggested that AtNUDX7 overexpression in Arabidopsis might enhance the ADP-ribose recycling step and maintain energy levels by supplying an ATP source in the poly(ADP-ribosyl)ation energy homeostasis pathway. Arabidopsis and maize lines with high, medium and low overexpression levels of the AtNUDX7 gene were analysed in automated platforms and the inhibition of several growth parameters was determined under mild drought stress conditions. The data showed that the constitutive overexpression of the Arabidopsis AtNUDX7 gene in Arabidopsis and maize at varying levels did not improve tolerance to mild drought stress, but knocking down AtNUDX7 expression did, however at the expense of general growth under normal conditions.
Modelo conceitual de sistema de alerta e de gestão de riscos e desastres associados a incêndios florestais e desafios para políticas públicas no Brasil
Authors: Anderson Liana Oighenstein , Marchezini Victor , Morello Thiago Fonseca , Cunningham Christopher Alexander
Published: March 2019

O aumento na ocorrência e de frequência de secas extremas tem ocasionado o aumento no número de desastres associados a incêndios florestais em todo o planeta. Neste artigo, buscamos contextualizar os incêndios florestais no âmbito de desastres socioambientais propondo uma estruturação de um sistema de gestão e de alerta de risco para este tipo de evento. Sugere-se a estruturação deste sistema baseado em cinco eixos principais, sendo eles: conhecimento do risco, monitoramento, educação e comunicação, capacidade de prevenção e capacidade de resposta. Em seguida, realizamos uma análise diagnóstica sobre as instituições, atribuições, responsabilidades e ações do governo brasileiro, nos níveis federal e estadual, em relação à gestão de riscos de incêndios florestais. Identifica-se a falta de uma regulamentação política e legal sobre as responsabilidades e estratégias para mitigar os riscos e impactos destes eventos. A partir dessa análise sobre as ações atuais, apontam-se alguns desafios à gestão integrada de risco de incêndios florestais no Brasil.
Paisagens protegidas e incêndios florestais em Brasília: produção voluntária de informações geográficas e sistema de alerta
Authors: Tavares Maria de Fátima Duarte , Nakagomi Bruno , Soares Vânia , Botega Leonardo Castro , Neris Vânia Paula De Almeida
Published: March 2019

As áreas protegidas do Cerrado, em Brasília, estão sendo progressivamente afetadas pela urbanização e por um quadro de recorrências de incêndios florestais. O estudo de caso da Estação Ecológica do Jardim Botânico de Brasília apresenta essas condições, que traduzem a relevância da participação da sociedade local nas dinâmicas de gestão de situações de risco. Neste âmbito, propõe-se um sistema de alerta para gestão da informação em processos decisórios e para estimular o reconhecimento social do problema por meio da produção voluntária de informações geográficas.
Esterification of Waste Cooking Oil Using Ultrasonic: Kinetic Study
Authors: Agustian Egi , Jessica Jessica , Untoro Pudji , Sulaswatty Anny
Published: March 2019

Waste cooking oil (WCO) have a great potential as an alternative raw material for producing biodiesel. The literatures kinetic of the esterification of WCO in the presence of phosphoric acid catalyst with ultrasonic assisted are rare and most literatures used conventional method. This study aims to determine the optimum condition and the parameters of first and second order kinetics of the WCO esterification which was assisted by ultrasonic bath. Variables that used in this study are methanol/oil mole ratio, acid catalyst concentration and reaction temperature. The highest conversion was 42.08% with methanol/oil mole ratio of 15:1, a catalyst (phosphoric acid) concentration of 9% wt and temperature of 50oC within 90 minutes. The reaction time was reduced to 3 times (minute) compare to conventional method and fatty acid reduced 42%. Kinetic parameters were calculated with assumption that the esterification was the irreversible reaction. The reaction rate constant increasing with temperature. The value of activation energy for esterification of WCO is 42.94 kJ/mol for first order reaction and 35.30 kJ/mol for second order reaction.
The Renewability Indicator and Cumulative Degree of Perfection for Gamboeng Tea; Part.2, Exergy Calculation of Tea Factory
Authors: Bardant Teuku Beuna , Haq Muthia Syafika , Rahman Setiawan Arief Ameir , Harianto Sugeng , Waluyo Joko , Mastur Adhi Irianto , Lestari Annisa Dieni , Sulaswatty Anny , Sujarwo Sujarwo , Rinaldi Nino , Wiloso Edi Iswanto
Published: March 2019

Renewability Indicator (RI) and Cumulative Degree of Perfection (CDP) were used to observe sustainability of Gamboeng Tea. The assessment then compared with black tea process in Black Sea Region in Turkey from the previous study. Calculation of exergy for Gamboeng fresh tea leaf had already described in Part.1. Since the main process for both production was drying, then tropical humid climate in Gamboeng is the main challenge to increase efficiency, and thus, renewability. This second part described the significant improvement of renewability had applied in Gamboeng by using wood pellet in rotary pannier. Further recommended improvement were by installing better humidity detector and connected to the process control so the process can adapt the ambient change which the relative humidity can be varied from 65% and up to 92%.
Effects of adjusting dynamic e-modulus to reference values of timber moisture and temperature in classification of small number of samples
Authors: Bjelanović Adriana , Franković Tomislav , Štimac Grandić Ivana
Published: March 2019

Mathematical dependences are derived for non-destructive testing (NDT) and destructive testing (DT) of three timber sets, each with six beams made of soft and hard structural timber. Very strong correlations were established between elastic moduli (e-moduli) determined by non-destructive testing, from dynamic ultrasound testing with direct propagation and static testing to bending action, and the correlation of e-moduli with bending strengths. The effects of adjustment of NDT results to reference values of moisture and temperature, and statistical significance of regression parameters, were evaluated from the standpoint of use in the initial classification of a small number of samples.
“DE LEIGA À RAINHA, CADA DIA MAIS DESTRUIDORA”: O ITINERÁRIO DO PROJETO EDUCAÇÃO, GÊNERO E SEXUALIDADE - PEGS
Authors: Ferreira Araújo Jonas Mateus , Andrade da Silva Wanderson Diogo
Published: March 2019

O presente relato é fruto do Projeto Educação, Gênero e Sexualidade – PEGS, que consistiu em uma pesquisa-ação desenvolvida durante os anos de 2015 a 2017 no colégio Liceu de Iguatu - CE, o qual objetivou compreender como se davam as relações de gênero e sexualidade na escola, buscando fornecer elementos para a superação das desigualdades historicamente construídas e ali existentes, fosse entre estudante ou professores/as. Para tal, realizou-se uma série de ações durante os três anos de projeto possibilitando a construção de um espaço educativo mais democrático, menos opressor e aberto à diversidade sexual.
RELATO DE UMA AÇÃO EXTENSIONISTA PROMOTORA DA EQUIDADE DE GÊNERO E DO RESPEITO À DIVERSIDADE NA UNIVERSIDADE
Authors: Trombini Frick Loriane , Gerotto del Mouro Karianny Aparecida , Rabelo Kiessow Alysson Mateus , Prochnow Igor , Coldebella Joyce , Tiberio Neves Leidyane
Published: March 2019

Este trabalho visa descrever as ações de um projeto de extensão, dentro da universidade, que tem por objetivo construir ações, a partir da interação dialógica com a comunidade, para a promoção da equidade de gênero e da garantia de direitos humanos para mulheres e público LGBTQIA+. Até o momento, foram realizadas oito atividades, na forma de palestras, rodas de conversas, oficinas e debates a partir de filmes e documentários, com as seguintes temáticas: violência sexual; violência doméstica contra a mulher e a efetivação da Lei Maria da Penha; sexo biológico, identidade de gênero, identidade afetivo sexual; violência contra pessoas LGBTQIA+; machismo e mulheres na ciência. Os participantes ressaltaram, ao longo das atividades, que as ações foram produtivas, esclarecedoras, inquietantes e promotoras da reflexão sobre a crescente perda de respeito pelo ser humano presente na nossa sociedade.
O Trabalho Associativo em Empreendimento de Economia Solidária e o papel da Educação Ambiental Crítica, Emancipatória e Transformadora
The Associative Work in Development of Solidarity Economy and the role of Critical, Emancipatory and Transformative Environmental Education
El trabajo asociativo en emprendimiento de economía solidaria y el papel de la Educación Ambiental Crítica, Emancipatoria y Transformadora
Authors: Umpierre Marcia Borges , Pecke Thierri Silva , Anello Lúcia De Fátima Socoowski de
Published: March 2019

O presente trabalho visa compreender como a economia solidária e a educação ambiental auxiliam no processo de emancipação e transformação de catadores e catadoras no sul do Rio Grande do Sul. Para tanto foram acompanhadas em torno de 68 reuniões, 4 assembleias ordinárias em cooperativas e associações, organização de documentos, realização de 9 oficinas de formação. Foram feitas observações e intervenções, algumas atividades foram propostas pelos pesquisadores e outras foram demandadas pelos grupos. Observou-se que todos os grupos apresentam características semelhantes, mas constatou-se ainda que cada grupo tem as suas especificidades, e necessidades, por vezes, distintas. Essas características estão diretamente relacionadas, com a forma que os grupos estão organizados, e como foram constituídos, bem como a maturidade dos grupos na realização das atividades.

The present work aims to understand how solidarity economy and environmental education help in the process of emancipation and transformation of pickers and pickers in the south of Rio Grande do Sul. For this purpose, 68 meetings, 4 ordinary assemblies in cooperatives and associations, organization of documents, 9 training workshops. Observations and interventions were made, some activities were proposed by the researchers and others were demanded by the groups. It was observed that all the groups have similar characteristics, but it was also verified that each group has its specifics, and sometimes different needs. These characteristics are directly related, with the way the groups are organized, and how they were constituted, as well as the maturity of the groups in the accomplishment of the activities.

El presente trabajo pretende comprender cómo la economía solidaria y la educación ambiental auxilian en el proceso de emancipación y transformación de recolectores y recolectores en el sur de Rio Grande do Sul. Para ello se acompañaron en torno a 68 reuniones, 4 asambleas ordinarias en cooperativas y asociaciones, organización de documentos, realización de 9 talleres de formación. Se hicieron observaciones e intervenciones, algunas actividades fueron propuestas por los investigadores y otras fueron demandadas por los grupos. Se observó que todos los grupos presentan características similares, pero se constató que cada grupo tiene sus especificidades, y necesidades a veces distintas. Estas características están directamente relacionadas, con la forma que los grupos están organizados, y cómo se constituyeron, así como la madurez de los grupos en la realización de las actividades.
Educação ambiental: uma proposta para a Educação Infantil
Environmental education: a proposal of early childhood education
Educación ambiental: una propuesta de educación infantil
Authors: Busik Carolina , Soletti Carolina Calixto , Caon Karen
Published: March 2019

Esse estudo buscou refletir sobre os principais fatores para uma educação ambiental no qual o grande crescimento do consumo e descarte imediato, o modo de vida individualista do ser humano, a utilização de recursos naturais limitados e o adensamento demográfico contribuem com a degradação do meio ambiente. Nessas perspectivas, a educação ambiental surge como uma proposta de ressignificação às práticas sustentáveis e ecológicas da vida humana. Na Educação Infantil, etapa da Educação Básica, a Educação Ambiental possibilita a sensibilização da criança por meio da apreciação, zelo e responsabilidade com o meio ambiente. Nessa pesquisa, apresenta-se ainda um relato de experiência desenvolvido durante um estágio curricular obrigatório do curso de pedagogia da Faculdade Murialdo com crianças de 3 a 6 anos de idade e atividades para uma Educação Ambiental na Educação Infantil.

This study aimed to reflect on the main factors for an environmental education, in which the great growth of consumption and immediate disposal, the individualistic way of life of the human being, the use of limited natural resources and the population density contribute to the environmental degradation. In these perspectives, the environmental education comes up as a proposal of resignification to the sustainable and ecological practices of the human life. In Early Childhood Education, the stage of Basic Education, the Environmental Education makes the awareness of the child possible through appreciation, zeal and responsibility with the environment. In this research, there is also an experience report developed during a mandatory curricular internship in Education at Murialdo College, with children aged 3 to 6 years old, and activities for an Environmental Education in Early Childhood Education.

Este estudio buscó reflexionar sobre los principales factores para una educación ambiental, en la cual el gran crecimiento del consumo y descarte inmediato, la manera de vida individualista del ser humano, la utilización de recursos naturales limitados y la densificación demográfica contribuyen con la degradación del medio ambiente. En estas perspectivas, la educación ambiental surge como una propuesta de resignificación a las prácticas sostenibles y ecológicas de la vida humana. En la Educación Infantil, etapa de la Educación Básica, la Educación Ambiental posibilita la sensibilización del niño por a través de la apreciación, cuidado y responsabilidad con el medio ambiente. En esta investigación, se presenta, también, un relato de experiencia desarrollado durante una pasantía curricular obligatoria del curso de pedagogía de la Facultad Murialdo, con niños de 3 a 6 años y actividades para una Educación Ambiental en la Educación Infantil.