bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of reduced activity of prefrontal cortex neurons on sleep rhythm
Authors: Lu Xin
Published: November 2024

Abstract. The etiology of depression, a prevalent psychiatric disorder, remains elusive. Depression often manifests as a sleep disturbance. A significant proportion of individuals suffering from depression exhibit various sleep rhythm problems. There occurs a well-established and intricate bidirectional association between sleep rhythm abnormalities and depression. The prefrontal cortex (PFC) has been demonstrated to have a crucial role in the development of depression in recent years. The PFC plays a crucial role in the regulation of several cognitive, emotional, behavioral, and other significant activities. The atypical functioning of the PFC might result in the disruption of the sleep cycle. Unusual neuronal activity in the PFC could play a crucial role in controlling both sleep problems and depression. This paper presents a comprehensive overview of the research methods employed in studying the PFC in animal models. It also investigates the potential neural mechanism by which reduced PFC neuron activity may impact sleep rhythm via the PFC-LH-HPA loop. By doing so, this study offers novel insights and concepts that contribute to a deeper comprehension of the underlying causes of depression. Furthermore, this research introduces a prospective approach for addressing depression and sleep disorders through the manipulation of PFC neuron activity, while also highlighting its medical implications and obstacles.
A comparative study of Chinese and foreign research relevant to the diffusion drift model in the last decade
Authors: Xu Mizhen
Published: November 2024

Abstract. This study evaluates the differential research approaches of Chinese and international scholars regarding the drift diffusion model in mental processes through a literature review from the last decade. The application of DDM theory in cognitive research varies between Chinese and foreign study methodologies. The differences in decision-making mechanisms among cultural groups result in this outcome. Inconsistency has been identified in international academic research. They cover reward rate optimization, decision thresholds, decision time, and more. On the contrary, advancements in Chinese studies involve the development of innovative models. They are Bayesian and semi-parametric. These are designed for mixtures combining drift-diffusion processes and the inverse Gaussian distribution. In addition, they encompass elucidating the neural processes and implementing DDM techniques. This use of DDM reveals the rewarding perception and decision-making linked to depression. It also reveals the brain patterns of social anxiety. These comparisons aim to summarize the differences between Chinese and foreign studies. They also analyze them. It will find the causes of these differences. Moreover, it will determine how Chinese clinical care can use them. The DDM studies show its importance in decision-making patterns. Scholars have the opportunity to apply these tools in a variety of scientific fields, including neuroscience, psychology, artificial intelligence, and cognitive research.
Omics techniques reveal the pathogenesis of microbial communities in asthma
Authors: Zhang Jiajun
Published: November 2024

Abstract. The presence of airway hyperresponsiveness in asthma provides the basis for constriction in bronchus response to a variety of stimuli, leading to limited airflow, dyspnea, wheezing, and chest tightness, threatening patients lives. Statistics have shown that asthma is more prevalent in the adolescents and children than in the adults, suggesting that early ecological dysregulation of the gut and airway microbiome contributes to the occurrence of asthma, especially in the preschool years children. With the development of high-throughput sequence technologies such as genomics, it has become possible to study the association of pathophysiological processes of allergic reactions and ecological dysregulation using the multi-omics techniques. In this review, the author first briefly introduces the classification of asthma, summarizes the pathogenesis of microorganisms in asthma, providing a new direction and ideas for the research of the pathogenesis, diagnosis, and treatment of asthma.
Analyses based on the function of false thumb in animals possessing false thumbs
Authors: Qiu Shaonan
Published: November 2024

Abstract. Throughout history, changes in climate in their living environments have led some animals to evolve a mysterious and fascinating structure, such as a false thumb. It evolved from radial sesamoid bone. It possesses functions such as grasping, deafferentation, and weight bearing. The possession of a false thumb is one of the most conspicuous cases of convergence in vertebrates. This study analyses the function as well as the morphology of the false thumbs of six animals with false thumbs. Giant panda (Ailuropoda melanoleuca), red panda (Ailurus fulgens), mole, aye-aye (Daubentonia madagascariensis) and spectacled bear (Tremarctos ornatus) separately. And based on the Darwinian theory of evolution, there are conjectures about the mechanism behind the creation of this false thumb phenomenon. An explanation of why all these animals with false thumbs chose to evolve radial seed bones instead of modifying their existing fingers is given from a philosophical as well as a Darwinian evolutionary perspective.
Advances in drug screening and toxicity testing: A review on Parkinson's disease using brain-on-a-chip
Authors: Wang Xuejie
Published: November 2024

Abstract. Neurodegenerative diseases like Parkinson's disease (PD) pose substantial challenges to health and well-being. PD is characterized by the progressive degeneration of dopamine-producing neurons in the substantia nigra of the brain, leading to motor dysfunction, cognitive decline, and various non-motor symptoms. Advances in drug screening and toxicity testing have transformed the study of neurodegenerative diseases. Traditional methods often fall short in replicating the intricate environment of the human brain, highlighting the necessity for alternative pre-clinical models. Brain-on-a-chip technology, an innovative in vitro platform, offers a promising solution by simulating the intricate architecture and microenvironment of brain tissue. This microfluidic device incorporates living brain cells within a controlled setting, enabling the examination of neuronal behavior, disorder mechanisms, and pharmacological responses in a physiologically relevant context. This review examines recent advancements in brain-on-a-chip systems for PD research, emphasizes their potential to advance drug discovery and toxicity testing, also discusses the difficulty and limitations of current brain-on-a-chip technologies, for examples, challenges of specific neuron cell selection and incubation, and also restriction of organ-organ connection. By comparing in vitro and in vivo studies, brain-on-a-chip technology shows great promise for accelerating the development of effective therapies for PD, ultimately contributing to improved patient outcomes and a deeper understanding of the disease.
Smoking status and interventions among children and adolescents in China
Authors: Bi Yiheng
Published: November 2024

Abstract. Tobacco use is the leading cause of preventable death globally. China is the Worlds large tobacco-producing and consuming country, and the burden of death and disease caused by tobacco use will continue to increase .The "Healthy China 2030" Planning Outline proposes to reduce the smoking rate of the population over the age of 15 to 20% by 2030. Taxation and price measures are recognized as the single most effective tobacco control policy measures. A variety of interventions are needed for adolescents, including China can carry out tobacco control according to the comprehensive tobacco control policy of WHO MPOWER (monitor,protect,offer,warm,enforce,raise),smoking ban in public places, cigarette sales to minors, prohibiting advertising promotion, raising the tobacco tax, adding health warnings to the cigarette packaging, use new media to expand coverage.
Targeted treatment of gastric cancer and its pathogenic mechanism
Authors: Huo Shengyi , Yao Muzhi
Published: November 2024

Abstract. Gastric cancer (GC) is a malignant tumor with high morbidity and mortality in our country. The traditional treatment methods include operation, radiotherapy and chemotherapy. At present, it cannot be cured by traditional treatment. Targeted therapy is a treatment method for GC targeting specific targets. Currently, the main therapeutic targets developed include HER2, VEGF and EGFR. It has the advantages of less side effects and good efficacy, but it still has the defect of not fully covering the patient population. This paper mainly introduces targeted therapy of GC, an emerging treatment method, and obtains relevant information about the pathogenic mechanism and main drugs of its main targets HER2, VEGF and EGFR. By summarizing the above information, this paper hopes to provide reference for the future research of targeted therapy of GC and make contributions to the development of more new targets of GC in the future.
Antidepressant drugs targeting on the histone deacetylase (HDAC) research progress
Authors: Ding Yi
Published: November 2024

Abstract. Depression is a high incidence, low clinical cure rate, and high recurrence rates of mental disorders. Antidepressant drug development has been going on for several years, and is widely used in the market of monoamine oxidase inhibitors, for example, tricyclic antidepressants. There has been a lot of progress, but they still can't take effect immediately, and may cause adverse reactions or other defects in the patients nervous system and urinary system. At present, with the rapid development of global society, people are facing increasing mental stress, and the high incidence of depression is becoming increasingly severe. The development of antidepressant drugs is of urgency and importance. This article from the perspective of epigenetics, is based on the modification of histone acetylation, analysis of depression causes the histones to acetylate enzyme (HDAC), and targeted at HDAC drugs, mainly HDAC inhibitors (HDACi). This article reviews the therapeutic effects and therapeutic mechanisms of histone deacetylase (HDAC)-targeted drugs on depression, so as to provide a reference for exploring new treatment methods for depression.
PCSK9 inhibitors in the research progress of atherosclerotic cardiovascular diseases
Authors: Huang Haijuan
Published: November 2024

Abstract. Atherosclerosis is a major global health issue, with cardiovascular diseases leading to over 4 million deaths in China in 2019. Effective management of atherosclerosis is crucial for reducing its incidence and mortality, with LDL-C reduction being a key strategy. This study examines the role of PCSK9 in atherosclerosis and the therapeutic potential of PCSK9 inhibitors, focusing on their ability to lower LDL-C levels and prevent cardiovascular events A literature review was conducted, analyzing the mechanisms of PCSK9 in lipid metabolism and the efficacy of various PCSK9 inhibitors, including monoclonal antibodies, antisense oligonucleotides, and small interfering RNA. PCSK9 inhibitors, such as Alirocumab, evolocumab, and Inlisiran, have demonstrated effectiveness in reducing LDL-C levels. Inlisiran, in particular, offers a long-lasting effect and has shown significant potential in clinical trials. Nucleic acid-based treatments are emerging as promising options with advantages such as sustained efficacy and a broad application scope, despite the need for further research to address delivery and off-target effects.
Mining autism causative SNPs based on CARMA algorithm
Authors: Miao Yufan
Published: November 2024

Abstract. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairment and repetitive stereotyped behaviors. This widespread neurological disorder not only results in symptoms that affect patients' social lives, such as behavioral and social disorders, but also imposes significant mental and economic burdens on their families. Therefore, research on the causes of ASD is of great practical value and significance. Previous studies have demonstrated a high genetic association with ASD and have identified specific ASD-related genes and single nucleotide polymorphisms (SNPs). However, these studies have primarily focused on establishing correlations rather than establishing causality between specific genes, SNPs, and ASD. Therefore, this experiment utilized public data from Genome-Wide Association Studies (GWAS) and employed a novel Bayesian model called CARMA (causal robust mapping method in meta-analysis) to identify SNPs strongly correlated with ASD. Notably, this study identified 14 novel pathogenic SNPs, four of which were deemed significant. Furthermore, functional annotations were performed on the pathogenic SNPs to assess their impact on gene expression in different brain regions. This analysis revealed the cerebellum, thalamus, and substantia nigra of the midbrain as the three brain regions with the highest correlation to ASD. Additionally, protein interaction analysis was conducted, revealing GATA-4 and NKX2-2 as the genes with the strongest correlation to ASD. The findings of this study provide new insights and data for future research into the genetics and biology of ASD, particularly in the field of basic research.
Towards thermophilic protein stability prediction: A comprehensive study of machine learning approaches
Authors: Wang Xin
Published: November 2024

Abstract. Thermophilic proteins are critical in biology due to their enhanced thermal stability. Different machine learning approaches have been applied to estimate protein thermal stability. Current study categorizes the previous research into classification and regression tasks and explores the impact of different data representations, including tabular, sequence, and graph data on evaluation performance. Pipelines for prediction using different representations are thoroughly described. Current challenges, such as insufficient and imbalanced datasets, are addressed with potential solutions, such as transfer learning and re-sampling methods. Additionally, model interpretability, discussing various approaches to obtain model explanations and highlighting that some explanations are inconsistent have also been included in current study. Such comprehensive overview provides insights into existing methodologies and suggests potential research directions and improvements.
Mechanisms of resistance to immune checkpoint inhibitors and solutions to the problem
Authors: Xia Yibo
Published: November 2024

Abstract. Immune checkpoint inhibitors (ICIs) have now become one of the major clinical treatments for tumors, which can inhibit the negative immunomodulation and thus enable the immune system to function to treat tumors. However, as with other treatments, patients develop clinical resistance to ICIs, which is an important cause of ICI treatment failure and tumor recurrence. The body acquires resistance to ICIs through pathways such as regulatory T cells (Treg) that increase the expression of other immune checkpoints to resist immunity, Wnt/-catenin that affect the secretion of IFN and IFN and thus suppress T-cell activation, and the NF-B pathway that induces B cells to arrest in the G2/M phase and thus inhibit the differentiation of B cells into germinal center B cells. Targeting Tregs at targets such as OX40, using the Wnt/-catenin inhibitor XAV-939, and combining ICIs with radiotherapy and chemotherapy can resolve the issue of resistance to ICIs. In this paper, we review the specific mechanisms by which ICIs develop resistance and possible future solutions, with the purpose of discovering ways to the efficiency of ICIs in addressing cancer and exploring new avenues for future cancer therapy. In the future era of individualized medicine, the application of precision medicine in the treatment of cancer with ICIs is equally worthy of consideration.
New Development of Vaccine Technology in Tumor Therapy
Authors: Xia Yueting
Published: November 2024

Abstract. Cancer vaccines are a crucial component of tumors immunotherapy, offering the advantage of minimizing adverse reactions to induce tumor regression. They also enable the establishment of lasting anti-tumor memory. Recent years have seen significant breakthroughs in cancer vaccines, including the customization of personalized vaccines and the transition from passive immunization to active treatment. Currently, most cancer vaccine future goals focus on improving cost and efficiency such as combining immunology and bioinformatics to predict more accurate vaccine epitopes. This paper focuses on three innovative technologies in therapeutic cancer vaccines: cell vaccine, peptide cancer vaccine and nucleic acid cancer vaccine. This paper summarizes new selection of antigen-presenting cells for autologous tumor cell vaccine and allogeneic tumor cell vaccine, new research on adjuvants of peptide cancer vaccines and new nucleic acid cancer vaccine delivery platform. In addition, the combination of therapeutic vaccines is briefly discussed. These new technologies offer cancer patients new treatment options and hope.
Research of the application of medical bionic robot
Authors: Zhou Shenyang
Published: November 2024

Abstract. Medical bionic robotics is one of the research hotspots in today's medical field, which is widely used in minimally invasive surgery, soft bionic robots, endoscopic instruments, and so on. Through reading and organizing related literature, this paper will describe the research status of medical bionic robot application in the form of a review, analyze the existing research results, find the research gaps, explore the optimization direction, and try to put forward the corresponding solutions. Medical bionic robot application technology can still be improved in many aspects to realize more comprehensive functions. Current research work not only explores knowledge or problems in specific fields, but also lays a foundation for future research and provides valuable reference information. This reference may include aspects such as methodology, data analysis techniques, experimental design ideas, theoretical frameworks, etc., which can help other researchers to conduct deeper or broader exploration in this field.
Challenge of electronic health record interface: literature review
Authors: He Jiali
Published: November 2024

Abstract. Electronic Health Record (EHR) differences from the traditional patient medical history in which everything related to the patients past visits and records such as family history or lab results are being stored electronically. This system is supposed to innovate the world of healthcare into the next step as it intends to provide different advantages such as ensure transparency cross different medical institute and enhance quality of care. However, due to the lack of different aspects, there are some major flaws with HER. This literature review explores the challenges of EHR interface design and its impact on healthcare providers across various medical settings. The paper demonstrates through research that the significant effects of EHR usability on provider efficiency and error rates, highlighting a notable disconnect between the design of these systems and the practical needs of their users. In addition, the review reveals a critical need for user-centered EHR interfaces, emphasizing the importance of collaborative efforts among clinicians, developers, and healthcare organizations. Based on a synthesizes findings from diverse studies, this paper advocate for EHR systems that are not only technically proficient but also intuitively aligned with healthcare providers' workflows, ultimately aiming to enhance clinical outcomes and operational efficiency.
Analysis of the embryotoxic effects of blastocyst culture medium in vitro fertilization technology
Authors: Li Zelin
Published: November 2024

Abstract. The culture medium for blastocysts contains components that may exhibit embryotoxicity, potentially affecting the developmental process of blastocysts and leading to abnormalities in the growth and development of offspring. This paper reviews and discusses the impact of blastocyst culture medium on the development of blastocysts and later-stage embryos. The results presented in the literature indicate that blastocyst media with different compositions not only affect development during the incubation period but may also have long-term effects on post-implantation development and maturation of embryos. The paper primarily summarizes the effects of the composition and concentration of blastocyst culture medium on embryonic development, aiming to further improve the quality of in vitro culture systems and optimize the culture conditions.
Environmental Risk Study of the Yuanjiang-Lishui River Basin in the Enshi Area
Authors: Dai Peiqi
Published: November 2024

Abstract. The Yuanjiang-Lishui River Basin in the Enshi Prefecture is located in the southwestern part of Hubei Province, China. It is an important tributary of the Qingjiang River Basin and falls within the secondary region of the Qingjiang River Basin. The total area of this basin is approximately 5,320 square kilometers, with most of the region falling under the administrative jurisdiction of Enshi Prefecture. This paper investigates the environmental risks faced by the Yuanjiang-Lishui River Basin in Enshi Prefecture, conducting an in-depth study and discussion of the existing environmental issues in the region and their causes. The study reveals that the Enshi area of the Yuanjiang-Lishui River Basin currently faces significant environmental problems, including severe flood disasters, an increasingly acute conflict between the supply and demand of water resources, and water pollution.
CRISPR-Cas9: Revolutionizing Crop Resistance Enhancemement
Authors: Huang Lanqi
Published: November 2024

Abstract. The security of food has grown to be a serious concern in recent years, due to factors such as environmental changes, pest infestations affecting crop yields and food safety. Traditional breeding methods, such as hybrid breeding, often involve long cycles, consuming substantial human and material resources and constrained by germplasm limitations, significantly hindering the rapid development of animal and plant breeding. In contrast, CRISPR-Cas9 genome editing technology allows precise modification of genetic information inanimals and plants at the molecular level, directly optimizing target traits or imparting new genetic characteristics, demonstrating more direct and efficient breeding advantages compared to traditional methods. The implementation and advancement of the CRISPR-Cas9 genome editing system to increase plant and animal resilience is the main topic of this review, which also discusses its drawbacks and potential applications.
The utilization of CRISPR-Cas9 with human pluripotent stem cell for Parkinson's disease modeling
Authors: He Yiping , Xing Xiaowen
Published: November 2024

Abstract. Parkinson's disease (PD), also often referred to as "parkinsonism," is a neurodegenerative disorder. Those afflicted with this condition are frequently elderly, which results in a considerable decline in their quality of life and overall well-being. Although there are major breakthroughs in PD research, there remains an incomplete grasp of the disease's pathogenesis and the formulation of innovative treatment approaches. This has led to an urgent need for a technology that can recapitulate all the features of human PD. The emergence of induced pluripotent stem cells (iPSC) coupled with the rising appeal of Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9 (CRISPR-Cas9) technology, the construction of PD models through the combination of iPSC and CRISPR-Cas9 has emerged as a crucial area of research in the field of PD. Employing patients' somatic cells, transformed into iPSC and integrated with CRISPR-Cas9 for genetic modification, has facilitated the duplication of the genetic makeup of neural cells associated with PD, thereby facilitating the investigation of the influence of diverse genotypes on disease progression and treatment response. This review outlines the application and future development of iPSC and CRISPR-Cas9 technologies for the study of Parkinson's disease pathogenesis. The technology enables scientists to gain a deeper understanding of PD and paves the way for the development of novel therapeutic approaches in the future.
Dimensões territoriais e ambientais das mulheres rurais no Bico do Papagaio
Authors: Liz Taynara Marcondes de , Hespanhol Rosangela Aparecida de Medeiros
Published: November 2024

O Bico do Papagaio, localizada na Amazônia Legal, é uma região marcada por conflitos agrários, que resultaram nos movimentos sociais de luta pela terra e pelo território. Surge nesse contexto, a atuação das mulheres rurais no protagonismo das lutas e mobilizações sociais. Este artigo investiga a importância da territorialidade das mulheres rurais, com ênfase nas quebradeiras de coco babaçu, na Microrregião do Bico do Papagaio, partindo dos pressupostos conceituais da sustentabilidade, desenvolvimento territorial e territorialidade como lentes teóricas. Com base na abordagem qualitativa e a realização de um estudo de caso, baseada na premissa de que grupos e indivíduos atribuem significados às suas ações e construções históricas, este trabalho revela como o protagonismo das mulheres rurais na defesa do território está intrinsecamente ligado a um desenvolvimento territorial sustentável. A partir de entrevistas com lideranças femininas no Bico do Papagaio, apresentamos os desafios atuais que essas mulheres enfrentam na luta e organização política e quais objetivos e perspectivas elas vêm construindo para enfrentar os obstáculos.
High Rate of Complications With Early Conversion Hip Arthroplasty Following Fracture Treatment
Authors: Grayson Whisper , Eikani Carlo , Benson Meredith , Jozefowski Nicolas , Brown Nicholas M.
Published: November 2024

Background:

Conversion total hip arthroplasty (THA) is associated with higher rates of complications compared with primary THA, with prior surgical fixation of fractures in the ipsilateral hip shown to further increase these rates. There is a scarcity of literature on the effect of timing of conversion THA on complication rates. In this study, we evaluated early (≤6 months of index surgery) and late (>6 months of index surgery) conversion to THA following prior fixation of the proximal femur or acetabulum.

Methods:

Ninety-one patients who underwent conversion THA following prior surgical fixation of either the proximal femur or acetabulum were identified. Index surgery, fracture characteristics, time, and cause of failure were obtained. Postoperative complications evaluated following the conversion THA included infection, revision surgery rates, dislocation, and revision rates.

Results:

A total of 91 patients were included, of which 22 underwent early conversion to THA. In the early conversion group, 22.7% of patients had a complication versus 11.6% of patients in the late conversion group (P = 0.194). The most common complications were deep infection (18.2% vs. 5.8%), revision surgery (22.7% vs. 10.1%), and revision THA (18.2% vs. 5.8%). The early conversion group had a markedly higher rate of perioperative blood transfusion compared with the late cohort (P = 0.013).

Conclusion:

In this study, we found a high rate of complications associated with early THA conversion. Patients should be counseled on the high risk for complications following early conversion to THA following failed fracture fixation.
A LEXICO-SEMANTIC DERIVATION OF ECONOMIC TERMINOLOGY
Authors:   Chechen State Pedagogical University, Khakieva Z. U. , Idrisov I. V. ,   Kadyrov Chechen State University
Published: November 2024

Abstract. The article addresses the lexico-semantic approach to the derivation of economic terminology in the English language. The method of deriving terms, which is the subject of our present enquiry, involves creating new terms that are based on existing lexical units, and which may be described as metaphorical, in that they reinterpret the meaning of these existing units. The use of metaphorical terms within a specific field of scientific knowledge reflects the distinctive characteristics of human thought and its cognitive processes. The lexico-semantic method of term derivation in English economic discourse entails the creation of metaphorical terms of diverse types. The most frequently represented are natural metaphorical terms, which are prevalent due to the high figurative potential of nature, particularly plants and animals. The term artefactual metaphorical terms' is used to describe a group of metaphors whose imagery is based on the peculiarities of using everyday objects. Anthropomorphic metaphorical terms correlate with people, their descriptions, and the peculiarities of their worldview. Sociomorphic metaphorical terms are related to the social structure in people's consciousness. The terms in this category allow for the tracing of structural and hierarchical relations that exist within the economy.
The influence of geographical particularities of the country on the conceptual sphere of the colombian variant of the Spanish language
Authors:   University of Science and Technology MISIS, Artamonov A.S.
Published: November 2024

The article demonstrates the influence of the geographical particularities of Colombia on the formation of the conceptual sphere of the national variant of the Spanish language. To achieve this goal there have been given a review of the theoretical staples of the cultural linguistics in particular in defining the terms “concept” and “conceptual sphere”. The significance of the study of culturally specific concepts is established. There have been given a brief geographical review of the territory, have been defined two superzones of dialects and the reasons for their formation. The comments were made upon the major linguocultural types – cachaco, costeño, paisa, caleño and the concepts related to them. The research was carried out by means of linguacultural comment with the elements of conceptual analysis. The results provided in the article let the professional in the field of translation and linguistics gain valuable knowledge about particularities of the Colombian national variant of the Spanish language. The relevance of the research is justified by the status of the Spanish language as a language of international communication.
ESTILO DE VIDA Y CLIMATERIO EN MUJERES DE UNA PARROQUIA MEXICANA
Authors: Itusaca Nelida Cayllahua , Islas Brenda Pamela Montiel , Martínez Liliana Lizbeth Meza , Sánchez Ariana Maya , Nolasco Benjamín López , García Claudia Atala Trejo , Itusaca Mercedes Cayllahua
Published: November 2024

El estilo de vida que construimos a lo largo de nuestra vida puede ser saludable o no, de modo que tendrá repercusiones importantes en la salud. La mujer en la etapa del climaterio experimenta diferentes cambios que pueden verse afectadas por cómo vive su estilo de vida. El estudio se llevó a cabo en una parroquia del estado de Hidalgo, México, con el objetivo de identificar cómo influye el estilo de vida en la sintomatología asociada al climaterio de las mujeres de 40 a 65 años que asisten a una Parroquia. La metodología del estudio fue de tipo cuantitativo, descriptivo y correlacional con una muestra conformada por 113 mujeres, el muestreo fue no probabilístico a conveniencia. Se aplicaron 2 instrumentos: Perfil de Estilo de Vida (PEPS-I) de Pender, confiabilidad por α de 0.863 y escala de Blatt Kupperman (IMK), confiabilidad por α de 0.820.  El proyecto fue aprobado por el Comité de Ética en Investigación. Los datos fueron analizados con el programa SPSS Vs 25, con estadísticos descriptivos y correlación de rho de Spearman. Los resultados revelaron que el estilo de vida de más de la mitad de las mujeres es saludable (73.5%) y la mayoría presenta sintomatología de intensidad moderada (42.5 %). En la correlación se obtuvo un p-valor de 0.297 > a 0.05 lo que determina que el estilo de vida no influye en la sintomatología del climaterio.   En conclusión, el estilo de vida de las mujeres durante el climaterio es saludable y no influye en la sintomatología asociada al climaterio.
The Influence of Work Discipline and Work Environment on Employee Performance in the General Affairs Division of the Regional Secretariat of Tangerang City
Authors: Handayani Devi Tri , Hasanah
Published: November 2024

The purpose of this study is to examine employee performance as the dependent variable influenced by work discipline and work environment, both of which serve as independent variables. The research method used is associative with a quantitative approach. The population consists of 40 employees, resulting in a sample of 40 respondents, which indicates the use of a saturated sample. Data analysis is conducted through classical assumption tests, including normality, multicollinearity, and heteroscedasticity tests. Additionally, multiple regression and R square analyses are utilized. The results indicate a positive and significant joint influence of work discipline and work environment on performance. Furthermore, there is a positive and significant partial influence of work discipline on performance, as well as a positive and significant partial influence of work environment on performance.
Wisselwerking tussen nationaal en EU-recht sinds Lissabon in de Ruimte voor vrijheid, veiligheid en recht
Authors: Hillary L. (Lynn)
Published: November 2024

Wisselwerking tussen nationaal en EU-recht sinds Lissabon in de Ruimte voor vrijheid, veiligheid en recht

Sinds het Verdrag van Lissabon is de Europese rechtsorde ten gronde veranderd. Dat is goed zichtbaar binnen de Ruimte voor vrijheid, veiligheid en recht, waarvan het strafrecht en het asielrecht deel uitmaken. In deze bijdrage wordt ingegaan op de top-down invloed van het EU-recht op het Nederlandse straf- en asielrecht, maar ook op de bottom-up invloed van het Nederlandse recht op het Europese niveau. In toenemende mate is er sprake van een wisselwerking tussen nationaal en EU-recht, zodat de nationale rechtsordes steeds meer geïntegreerd raken in de samengestelde Europese rechtsorde.
Een sprong in het diepe
Authors: van der Aa S. (Suzan) , Pemberton A. (Anthony)
Published: November 2024

Een sprong in het diepe: het Verdrag van Lissabon en de implementatie en borging van slachtofferrechten in Nederland

De impact van het Verdrag van Lissabon op de Nederlandse rechtsorde is beperkt geweest, omdat veel van de in de EU-slachtofferrichtlijn genoemde rechten reeds deel uitmaakten van het Nederlandse slachtofferbeleid. Toch blijft vooral de implementatie van slachtofferrechten in de praktijk voor verbetering vatbaar. Mogelijke oplossingen voor de geconstateerde tekortkoming brengen ons weer terug bij het Verdrag van Lissabon, wanneer we gaan nadenken over een combinatie van voorzieningen in rechte, collectieve voorzieningen en non-juridische mechanismes om slachtofferrechten te borgen.
Invloed uitoefenen op de totstandkoming van strafrechtelijke EU-wetgeving
Authors: Verrest P.A.M. (Pieter)
Published: November 2024

Invloed uitoefenen op de totstandkoming van strafrechtelijke EU-wetgeving

De Europese Unie brengt steeds meer strafrechtelijke wetgeving tot stand. EU-strafrecht is inmiddels een belangrijke bron voor de ontwikkeling van ons materieel strafrecht en strafprocesrecht. Dat levert zowel kansen op als uitdagingen. Om daar goed mee om te gaan, zou Nederland zich in Brussel actiever moeten opstellen. In deze bijdrage worden daartoe een aantal mogelijkheden belicht, waarmee regering, Tweede Kamer, praktijk en wetenschap aan de slag zouden moeten.
The Judicial Duty to State Reasons in the Age of Automation? The Impact of Generative AI Systems on the Legitimacy of Judicial Decision-Making
Authors: Hendrickx Victoria
Published: November 2024

The Judicial Duty to State Reasons in the Age of Automation? The Impact of Generative AI Systems on the Legitimacy of Judicial Decision-Making

The steady reliance on algorithmic and artificial intelligence (AI) systems within judicial proceedings poses several risks to fundamental rights, including the judicial duty to state reasons. The judicial duty to state reasons refers to the obligation of judges to provide reasons whenever they rule in a case. Although this duty constitutes an essential component for the rule of law and the right to a fair trial, and pursues important normative goals, it has not been studied much – let alone in the age of automation. Through the analysis of the case study of generative AI systems assisting judges in their legal drafting, this article aims to explore how and to what extent such systems can affect the judicial duty to state reasons. To this end, the article focuses on the impact of generative AI systems on one of the underlying normative values of this duty, notably the legitimacy of judicial decision-making. The assessment shows that while generative AI systems can strengthen the legitimacy of judicial decision-making and thereby the judicial duty to state reasons, they simultaneously impede it in various ways. The article therefore briefly reflects on possible avenues to uphold the judicial duty to state reasons in the age of automation. It highlights the importance of AI literacy and explores the potential of enhanced transparency, accountability and legitimacy through a more robust duty to state reasons, while also acknowledging the limits of such approaches.
Bases metodológicas para proponer la terminología del área de Diseño Gráfico y Tipografía
Authors: González-Miranda Elena , Álvarez Sandi Laura , Quindós González Tania
Published: November 2024

En este estudio se propone un reajuste de los procedimientos metodológicos de la Lingüística de corpus, a nuestra especialidad, para reunir la terminología de un diccionario ilustrado de Diseño Gráfico y Tipografía. Con este enfoque se perfila nuestra propuesta metodológica, se estructura un árbol de campo temático de la disciplina para emplazar las voces técnicas, y se definen los criterios para la recopilación del corpus de vaciado, desde donde se han detectado y extraído las entradas léxicas, conformando así la nomenclatura del diccionario.
Optic Disc Pit Maculopathy in a Nine -Year-Old Child: A case report
Authors: El Sayegh Ahmed Mohammed , Eltelbany Elsaid Elsaid , Helaly Mohamed Refaat
Published: November 2024

Background: Optic disc pit is a rare optic disc abnormality. It appears as a round or oval, gray, white, or yellowish depression in the optic disc. This disorder can be associated with serous retinal detachment which results on a visual deterioration. Optic pit-associated maculopathy generally occurs in the third and fourth decade of life. The development of optic disc pit maculopathy (ODP-M) in childhood is rare and there are not enough studies on the treatment methods. Therefore, our case report may be helpful in the management of similar cases of paediatric optic disc maculopathy.
Case report: There is a little current consensus on treatment of pediatric optic disc pit-associated maculopathy. In this article, we report a case of an optic disc pit maculopathy in a 9 years old patient, who presented for a routine change of glasses, with a history of gradual deterioration of vision in left eye since 4 months. The fundus examination of the left eye showed a macular retinal serous detachment and a temporal oval optic disc pit gray in color, while ocular examination of the right eye was completely normal. Spectral Domain- Optical coherence tomography (SD-OCT) of the left eye showed a large serous retinal detachment with macular retinoschisis and cystoid macular edema. Spontaneous regression can occur in the pediatric optic disc pit maculopathy after several months.
Conclusion: ODP-M is a rare condition that presents usually in the third or fourth decade of life. In the present case, it appeared in an earlier age than mostly reported. With regular follow up, spontaneous regression eventually happened after several months.
Beyond usability: innovation in the digital age as an antidote to social isolation
Authors: Lui Márcio de la Cruz , Bernardes Roberto Carlos , Oliveira Mauro José de , Sumlin Cameron
Published: November 2024

The study's objective: The article aims to evaluate the impact of life satisfaction during the COVID-19 pandemic in Brazil, considering the perception of usability of intelligent personal assistants (IPAs) and investigating possible moderations of consumer innovation dimensions in this relationship.
Methodology/Approach: Field research was carried out with 515 users of intelligent personal assistants (IPAs). The results were analyzed using multiple linear regression, using the SPSS software (Statistical Package for Social Science v.22), with the application of the PROCESS macro.
Originality/Relevance: This study contributes to filling a gap in the literature on the diffusion of innovation and adoption of technological products by investigating aspects of innovative consumption in a pandemic and social isolation scenario.
Main Results: The research results indicate that domain-specific innovativeness (DSI) moderates the relationship between usability (SUS) and life satisfaction (LS). In contrast, innovativeness behavior (IB) moderates this relationship only with DSI maintained at medium and low levels. It was observed that, with greater usability, life satisfaction increases and is moderated by domain-specific innovativeness. For higher IB levels, LS increases more quickly.
Theoretical/Methodological Contributions: Integrating concepts from theories of innovative consumption and diffusion of innovations, the study offers insights into how technology affects well-being in a global crisis. This advanced approach helps understand the mechanisms underlying the impacts of usability and innovation on human behavior.
Social/Managerial Contributions: This study helps understand how IPA users can experience greater life satisfaction and social isolation during a pandemic.
O impacto social das teses, dissertações e artigos acadêmicos: alinhando a pesquisa acadêmica às necessidades da sociedade
Authors: Serra Fernando Antonio Ribeiro , Menezes Daniela Cíntia de Carvalho Leite , Ramos Heidy Rodriguez , Ribeiro Ivano
Published: November 2024

O impacto social de teses, dissertações e artigos acadêmicos tem recebido crescente atenção tanto na comunidade científica quanto na sociedade em geral. Este conceito abrange os benefícios tangíveis que a pesquisa pode trazer para a indústria, políticas públicas e a sociedade, além dos avanços no conhecimento acadêmico (Davison & Bjørn-Andersen, 2019; Fecher & Hebing, 2021). A relevância de uma pesquisa acadêmica deve ser medida não apenas por sua contribuição teórica, mas também por sua capacidade de promover mudanças práticas e melhorias na vida das pessoas.
O impacto social engloba as contribuições benéficas para a economia, sociedade, cultura, políticas públicas, serviços de saúde, meio ambiente e qualidade de vida, além das contribuições acadêmicas (Davison & Bjørn-Andersen, 2019; Fecher & Hebing, 2021). Esse impacto pode ser categorizado em formas acadêmicas, práticas, sociais, políticas e educacionais (Wickert et al., 2020).
Analisar o impacto social das pesquisas acadêmicas envolve identificar e quantificar como os resultados são utilizados por stakeholders não acadêmicos, incluindo formuladores de políticas, profissionais da indústria e a comunidade em geral. Isso abrange tanto impactos comuns, resultantes de interações cotidianas na criação e aplicação do conhecimento, quanto impactos extraordinários, que incluem descobertas e soluções transformadoras para desafios sociais (Sivertsen & Meijer, 2020).
Este comentário editorial busca explorar o impacto social de teses, dissertações e artigos dentro da linha de pesquisa de estratégia. A relevância deste tema reside em evidenciar como as pesquisas podem transcender o âmbito acadêmico, contribuindo de maneira prática e significativa para o desenvolvimento sustentável, inovação organizacional e bem-estar social (Davison & Bjørn-Andersen, 2019; Fecher & Hebing, 2021; Wickert et al., 2020). Além disso, são indicadas recomendações para os autores sobre como maximizar o impacto de suas pesquisas e reforçar a relevância dessas contribuições nos periódicos científicos.
Qualidade da água utilizada na pesca artesanal de moluscos bivalves, na Costa amazônica maranhense
Authors: Pereira Gisely Jovita , Brito Daniella de Jesus Castro , Pereira Natália Jovita , Maia Monique Pinheiro , Costa Francisca Neide
Published: November 2024

Dentre os estados da Amazônia Legal, o Maranhão possui a menor ocupação de espaço com áreas protegidas, acarretando em ocupação humana desordenada e gerando baixos índices de desenvolvimento social e ambiental. As recorrentes poluições e contaminações dessas regiões propiciam condições ideais para o desenvolvimento de microrganismos e contaminação química, depreciando a qualidade da água. Desta forma, esta pesquisa tem como objetivo avaliar a qualidade microbiológica e físico-química das águas de bancos naturais de municípios da Costa amazônica do Maranhão. Para tal, coletas foram realizadas no período de chuva e de seca, entre março e dezembro de 2022. Para a determinação de coliformes totais e Escherichia coli nas amostras de água, foi utilizado o método Colilert® e os parâmetros físico-químicos incluem pH, concentração de Fe, NaCl, nitrato e nitrito. Os resultados da contagem de E. coli nas amostras de água variaram entre 220 NMP/100 mL e valores maiores que 2419,6 NMP/100 mL, no período de chuva, enquanto no período de seca foi de 73 NMP/100 mL e valores maiores que 2419,6 NMP/100 mL, indicando qualidade microbiológica insatisfatória, segundo dados preconizados na Resolução CONAMA N° 357 de 2005.
Sustentabilidade e a nova hotelaria
Authors: Fernandes Alexandre Laurindo
Published: November 2024

A sustentabilidade na hotelaria está se tornando cada vez mais crucial à medida que o setor reconhece sua responsabilidade ambiental e social. A hospitalidade sustentável abrange práticas que minimizam o impacto ambiental, promovem a conservação de recursos e incentivam o engajamento social e comunitário. Hotéis em todo o mundo estão adotando iniciativas verdes, como a redução do consumo de energia e água, a gestão eficiente de resíduos e a utilização de fontes de energia renovável. Essas práticas não apenas diminuem a pegada ecológica, mas também resultam em economias financeiras significativas a longo prazo. A sustentabilidade na indústria hoteleira tem se destacado cada vez mais como uma questão de importância fundamental. Diante dos desafios ambientais globais e da crescente conscientização sobre a responsabilidade social das empresas, os hotéis estão cada vez mais buscando formas de integrar práticas sustentáveis em suas operações. Neste contexto, surge a necessidade de um estudo aprofundado sobre hotéis sustentáveis e os impactos positivos que podem gerar tanto para o meio ambiente quanto para a própria indústria da hospitalidade (Ribeiro, 2022). A educação e a sensibilização dos funcionários e hóspedes sobre a importância da sustentabilidade serão fundamentais. Programas de formação e campanhas de conscientização ajudam a garantir que todos os envolvidos estejam alinhados com os objetivos sustentáveis do hotel. À medida que a sustentabilidade se torna um pilar central da indústria hoteleira, ela não só ajudará a mitigar os impactos ambientais, mas também proporcionará uma experiência de hospitalidade mais rica e significativa.