The association of thrombophilia in women with severe obstetric complications
Authors: Alzahrani Faisal Mousa ,   Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Al-Mulhim Abdulaziz ,   Department of Obstetrics and Gynecology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Shaikh Saeed Sattar ,   Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia,   Saeed Sattar Shaikh, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. E-mail: ssshaikh@iau.edu.sa., Aldossary Maryam Ahmed ,   Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Aldarmahi Ahmed ,   Department of Basic Science, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia, Alnaam Yaser ,   Department of Clinical Laboratory Sciences, Prince Sultan Military College of Health Science, Dhahran, Saudi Arabia, Al-Jamea Lamiaa Hammad ,   Department of Clinical Laboratory Sciences, Prince Sultan Military College of Health Science, Dhahran, Saudi Arabia, AL-Maqati Thekra ,   Department of Clinical Laboratory Sciences, Prince Sultan Military College of Health Science, Dhahran, Saudi Arabia, Elnagi Elmoeiz ,   Department of Clinical Laboratory Sciences, Prince Sultan Military College of Health Science, Dhahran, Saudi Arabia, Hassan Fathelrahman Mahdi ,   Department of Hematology and Immunohematology, College of Medical Laboratory Sciences, Sudan University of Science and Technology, Khartoum, Sudan, Muzaheed  ,   Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
Published: November 2022

Thrombophilia, where multiple genetic and acquired risk factors interact synergistically, are associated with thrombosis and pregnancy-related complications. Despite being studied profusely, an inconsistent association exists between thrombophilia and pregnancy complications. Between 2018 and 2020, ninety-three women with pregnancy complications were enrolled in the study. Twenty-five healthy pregnant women without pregnancy complications reported to the same hospital were also recruited as controls. Blood samples were tested for homocysteine, coagulation studies, and molecular diagnosis included FVL, PTH and MTHFR genes amplified using PCR strip assay (Vienna Lab Diagnostics, Austria). Other thrombophilia screening, including testing for AT, PC, and LA, were done by chromogenic assays (Dade Diagnostica, Munich, Germany). Homocysteine level was determined by fluorescence polarization immunoassay technology (Axsym, Abbot company, Germany). Overall, 29.03% of women with pregnancy complications had thrombophilia relative to 16% in the control group. However, the difference between the case and control groups did not reach a significant level (p=0.1175). Additionally, combined thrombophilia was more prevalent among cases (10.75%) than in the control group (4%). However, the difference did not reach statistical significance (p=0.1046). Our study demonstrated that the frequency of thrombophilia among healthy women was 16%, and among women with pregnancy-related complications, 29%. Relative to control, all measured thrombophilia markers were more frequent in women with pregnancy-related complications except for LA. Including all the studies on the Saudi population in a meta-analysis study could reveal more information about thrombophilia and pregnancy-related complications in our population.