bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of a Metabolic Gene Signature in Response to Respiratory Viruses and Type I Interferon Signaling
Authors: Ramana Chilakamarti V.
Published: March 2024

Respiratory viruses are the causative agents responsible for seasonal epidemics and occasional pandemic outbreaks and are a leading cause of death worldwide. Type I interferon (IFNα/β) signaling in the lung epithelial cells plays a major role in the innate immunity to respiratory viruses. Gene signatures are a set of differentially expressed genes in a particular disease or condition and are used to diagnose, monitor, and predict disease progression. These signatures can be used to identify regulatory modules and gene regulatory networks (GRNs) in mammalian signal transduction pathways. Considerable progress has been made in the identification of type I interferon-regulated gene signatures in the host response to respiratory viruses, including antiviral, immunomodulatory, apoptosis, and transcription factor signatures. Respiratory virus infections and host defenses require a dramatic change in the metabolic flux of macromolecules involved in nucleotide, lipid, and protein metabolism. The profiling of IFN-stimulated metabolic genes induced in the host response to several respiratory viruses led to the identification of a common gene signature in human lung epithelial cells and in the lungs of mouse models of respiratory virus infection. The regulation of the metabolic gene signature was correlated with the induction of IFN-beta (IFN-β) and IFN-inducible transcription factors at the RNA level in lung epithelial cells. Furthermore, the gene signature was also detected in response to bacterial lipopolysaccharide-induced acute lung injury. A protein interaction network analysis revealed that metabolic enzymes interact with IFN-regulated transcription factors and members of the unfolded protein response (UPR) to form a module and potentially regulate type I interferon signaling, constituting a feedback loop. In addition, components of the metabolic gene expression signature were differentially regulated in the lung tissues of COVID-19 patients compared with healthy controls. These results suggest that the metabolic gene signature is a potential therapeutic target for the treatment of respiratory virus infections and inflammatory diseases.
Description and Pathogenicity of Colletotrichum kapreanum sp. nov, a Cherelle Wilt Pathogen Belonging to the Gigasporum Species Complex
Authors: Takata Yoshiki , Ocampo-Padilla Celynne , Malonzo Mike Andre C. , Pangilinan Dan Charlie Joy Camara , Nozawa Shunsuke , Watanabe Kyoko
Published: March 2024

Similar to cacao pod rot, cherelle wilt decreases production from cacao fields. Among all known fungal pathogens of the cacao, Colletotrichum spp. are common infectious agents that affect the cherelles and pods of cacao; thus, cacao diseases are often classified by stage. Therefore, knowing whether these pathogens are common in both fruit stages is necessary for implementing disease control measures. Symptoms of cherelle wilt were found in cacao plants in Pangasinan, Philippines, in 2022. The fungal strain obtained from the lesion was found to be pathogenic towards cherelles, but not towards pods. The strain was classified as an unknown species belonging to the gigasporum species complex, based on the morphological and molecular phylogenetic analyses of ITS, GAPDH, CHS1, ACT, and TUB2. We propose Colletotrichum kapreanum sp. nov. as a causal agent of cacao cherelle wilt, but not pod rot.
Education in Interventional Pulmonology: How We Got Here and Where to Go from Here
Authors: Harrell Dylan , Chambers David M.
Published: March 2024

Interventional pulmonology is a rapidly growing field with increasing demand. To meet this demand, training in interventional pulmonology is expanding. What started as a single training program without a standardized curriculum has grown to 40 accredited training programs with a well-defined curriculum that is now overseen by the Accreditation Council for Graduate Medical Education. As the field develops, research is being actively performed to develop validated competency assessment tools and describe the learning curves for pulmonary procedures. As research evolves, this information can be used to better standardize training in interventional pulmonology and move the field towards a competency-based training model.
The Hemodynamic Profile and Intraoperative Bleeding Impact on Liver Transplant Patients
Authors: Brezeanu Lavinia Nicoleta , Jercălău Cosmina Elena , Andrei Catalina Liliana , Ceban Octavian , Droc Gabriela
Published: March 2024

Liver transplantation is the treatment of choice for end-stage liver disease and despite accumulated experience over the years, improved surgical techniques, better immunosuppression and adequate intensive care management, it still represents the greatest challenge for anesthesiologists. The aim of the study was the characterization of the hemodynamic profile of patients with liver cirrhosis undergoing liver transplantation with the help of the PiCCO system during the three surgical stages, the impact of bleeding on hemodynamic status and correlation between the amount of bleeding, lactate levels, severity scores and survival rate and complications. Another focus of this study was the amount of transfused blood products and their impact on postoperative complications. Our study included 70 patients who underwent liver transplantation in our center and were hemodynamically monitored with the PiCCO system. Data were processed using the Python 3.9 programming language. Results: The mean MELD severity score was 18 points. During surgery, significant variations in the hemodynamic parameters occurred. All patients had a decrease in cardiac output in the anhepatic phase, with 50% presenting a decrease of more than 40%. In total, 78% of patients showed a decrease in the global ejection fraction, with a median value of 30%.Overall, 75% of patients had a total blood loss of less than 6000 mL and 31 patients developed immediate postoperative complications with a 50% probability with blood loss exceeding 6500 mL. Seven patients (10%) did not survive after 30 days. An amount of 5 mmol/L of serum neohepatic lactate determines a 50% probability of complications. Conclusions: Surgical technique causes an important decrease in cardiac output. Intraoperative bleeding has a major impact on outcome and the first month represents a critical period after liver transplantation. Statistical tests describe the probability of 30/90-day survival and the occurrence of complications according to variables such as intraoperative bleeding and MELD severity score. Intraoperative transfusion correlates with the occurrence of postoperative complications.
Assessment of Arterial Stiffness and Biochemical Markers in Systemic Lupus Erythematosus in the Diagnosis of Subclinical Atherosclerosis
Authors: Blachut Dominika , Przywara-Chowaniec Brygida , Mazurkiewicz Michalina , Tomasik Andrzej
Published: March 2024

Patients with systemic lupus erythematosus (SLE) are 2–10 times more likely to develop cardiovascular disease (CVD) than the general population. The assessment of the risk of developing CVD is an important direction for further clinical management. The study was conducted retrospectively and included patients with SLE. The aim of the study was to assess the measurements of pulse wave velocity (PWV), carotid intima-media thickness (CIMT), ankle–brachial index (ABI) and biochemical parameters. Subclinical atherosclerosis was also assessed. The study included 98 patients with SLE with an age- and sex-matched control group of 68 healthy adults. Statistical significance was found in the SLE group and the controls for N-terminal fragment of pro-B-type natriuretic peptide (NT proBNP) (144.87 vs. 36.41 pg/mL, p = 0.0018), high-sensitivity cardiac troponin (hs-cTn) (25.43 vs. 6.38 ng/L, p = 0.0303) and D-Dimer levels (0.73 vs. 0.36 µg/mL, p = 0.0088), left CIMT (1.03 vs. 0.62 mm, p < 0.0001), right CIMT (0.93 vs. 0.63 mm, p < 0.0001) and PWV CF (9.74 vs. 7.98 m/s, p = 0.0294). A positive correlation was found between NT proBNP and PWV CF (r = 0.6880, p = 0.0498) and hs-cTn and PVW carotid-femoral (CF) (r = 0.8862, p = 0.0499) in SLE. A positive correlation was reported between PWV CF and systolic blood pressure (r = 0.5025, p = 0.0487). The measurement of carotid–femoral PWV is a simple, non-invasive, and reproducible method and may independently predict future CVD events and their cause. Further studies are warranted to establish the prognostic value of PWV in patients with SLE, as it may be superior to CIMT measurements in the early stages of vascular disorders.
Microduplication and Microdeletion Syndromes Diagnosed Prenatally Using Single Nucleotide Polymorphism Array
Authors: Iordănescu Irina Ioana , Catana Andreea , Cuzmici Zina Barabas , Chelu Iuliana , Dragomir Cristina , Militaru Maria , Severin Emilia , Militaru Mariela Sanda
Published: March 2024

We present a series of microdeletion and microduplication syndromes (MMSs) observed in our clinical practice over a three-year period from 2020 to 2023. Microdeletion and microduplication syndromes, characterized by chromosomal deletions or duplications of less than five megabases, pose challenges in terms of diagnosis, especially prenatal and clinical management. Clinically, MMSs encompass a broad spectrum of manifestations, ranging from intellectual disability and developmental delays to congenital anomalies, facial dysmorphisms, and neurobehavioral abnormalities. Notable examples include well-characterized syndromes such as DiGeorge syndrome (22q11.2 deletion), Prader–Willi syndrome (15q11–q13 deletion), and Williams syndrome (7q11 deletion). Our study focuses on the genetic foundations and prenatal ultrasound findings of these syndromes, with an emphasis on cases associated with intellectual disability. Using SNP array technology, we delve into the evolving landscape of diagnostic methods, providing a nuanced understanding of copy number variations (CNVs) and their implications. Prenatal diagnosis allows for the early detection of MMSs, enabling parents and healthcare providers to make informed decisions about the pregnancy and plan for appropriate medical care and interventions. Beyond theoretical considerations, our article bridges the gap between research and practical application by offering insights derived from clinical cases. Through the presentation of specific cases, we aim to contribute valuable data to the broader discourse on MMSs, fostering knowledge exchange and enhancing the medical community’s awareness of these complex genetic conditions.
Assessing the Impacts of Climate and Land Use Change on Water Conservation in the Three-River Headstreams Region of China Based on the Integration of the InVEST Model and Machine Learning
Authors: Xie Xinyue , Peng Min , Zhang Linglei , Chen Min , Li Jia , Tuo Youcai
Published: March 2024

The Three-River Headstreams Region (TRHR) serves as the cradle of China’s three major rivers—the Yangtze, Yellow, and Lancang—rendering its water conservation (WC) capacity quintessentially significant for Asian water resource security. This study integrated the InVEST model and random forest model to holistically elucidate the spatiotemporal characteristics and factors influencing WC in the TRHR from 1980 to 2018. The results revealed that the WC growth rate was 5.65 mm/10a in the TRHR during the study period, yet pronounced regional disparities were observed among different basins, especially with the Lancang River Basin (LRB), which exhibited a decrease at a rate of 5.08 mm per decade despite having the highest WC. Through Theil–Sen trend analysis, the Mann–Kendall abrupt change test, and the cumulative deviation method, meteorological, vegetative, and land use abrupt changes in approximately 2000 were identified as the primary drivers for the abrupt surge in WC within the TRHR. Furthermore, precipitation and the aridity index were the core feature variables affecting WC. However, a positive transition in land use patterns post-2000 was also revealed, and its favorable effect on WC was not as significant as the abrupt climatic changes. This study offers new perspectives on managing multidimensional spatiotemporal data and contributes to laying the groundwork for machine learning applications in water conservation. Additionally, it potentially provides useful references for decision-making processes related to ecosystem security.
A Comparative Analysis of Declarative Sentences in the Spontaneous Speech of Two Puerto Rican Communities
Authors: Visconte Piero , Sessarego Sandro , Rao Rajiv
Published: March 2024

This paper applies the Autosegmental Metrical (AM) model of intonation phonology and the Spanish Tones and Break Indices (Sp_ToBI) annotation conventions to compare the intonational contours of declarative sentences in two varieties of Puerto Rican Spanish: (1) San Juan Spanish, spoken in the capital city of San Juan, and (2) Loíza Spanish, an Afro-Hispanic vernacular spoken in Loíza. The geographical proximity between these two municipalities entails constant contact within a shared linguistic space. However, speakers from San Juan perceive Loíza as a municipality that has its own peculiar way of speaking. The acoustic and phonological analysis was carried out with PRAAT to verify whether pitch accents coincide in the spontaneous speech of the two analyzed varieties. The data we examined contain an overall predominance of the bitonal pitch accents L*+H and L+<H* in San Juan Spanish, and L+H* in Loíza Spanish. Findings show both similarities and differences within the two speech communities, as well as with intonational patterns in other (Afro-)Hispanic varieties. These results provide new information on spontaneous declarative intonation in (Afro-)Puerto Rican Spanish by offering a new perspective on the origin of a set of the prosodic phenomena found in these two varieties.
The Effect of the Solution Flow and Electrical Field on the Homogeneity of Large-Scale Electrodeposited ZnO Nanorods
Authors: Zhao Yanmin , Li Kexue , Hu Ying , Hou Xiaobing , Lin Fengyuan , Tang Jilong , Tang Xin , Xing Xida , Zhao Xiao , Zhu Haibin , Wang Xiaohua , Wei Zhipeng
Published: March 2024

In this paper, we demonstrate the significant impact of the solution flow and electrical field on the homogeneity of large-scale ZnO nanorod electrodeposition from an aqueous solution containing zinc nitrate and ammonium nitrate, primarily based on the X-ray fluorescence results. The homogeneity can be enhanced by adjusting the counter electrode size and solution flow rate. We have successfully produced relatively uniform nanorod arrays on an 8 × 10 cm2 i-ZnO-coated fluorine-doped tin oxide (FTO) substrate using a compact counter electrode and a vertical stirring setup. The as-grown nanorods exhibit similar surface morphologies and dominant, intense, almost uniform near-band-edge emissions in different regions of the sample. Additionally, the surface reflectance is significantly reduced after depositing the ZnO nanorods, achieving a moth-eye effect through subwavelength structuring. This effect of the nanorod array structure indicates that it can improve the utilization efficiency of light reception or emission in various optoelectronic devices and products. The large-scale preparation of ZnO nanorods is more practical to apply and has an extremely broad application value. Based on the research results, it is feasible to prepare large-scale ZnO nanorods suitable for antireflective coatings and commercial applications by optimizing the electrodeposition conditions.
An Experimental Investigation of the Material Properties of the A356 Aluminum Alloy Power Fittings in the Vacuum Die-Casting Process
Authors: Zhao Jianli , Wang Yilin , Wang Xiaowei , Zhang Yisheng
Published: March 2024

To enhance the performance of ultra-high voltage power fittings in severe weather conditions without altering their current structure, the high-strength and toughness aluminum alloys were rationally selected to study the optimization of the die-casting process. This approach aims to improve the overall longevity and function of the power fittings in extreme climates. First of all, the propose of this study is to use the material’s strength–toughness product (STP) concept to evaluate the material stability of the power fitting impact resistance and fatigue toughness in order to determine the appropriate material selection. Secondly, the location of the mold’s sprue and gate was optimized through finite element simulation to prevent gas volume and flow defects during the casting process. This improves the material’s toughness and anti-fatigue failure characteristics of the product. Then, vacuum equipment and a vacuum valve auxiliary system were added based on the existing die-casting machine, and the mold structure was optimized to enable the vacuum die-casting process. Finally, a water-based boron nitride environmentally friendly mold release agent was used to solve demolding difficulties with an A356 aluminum alloy and improve mold lubrication and surface quality. The production of quad-bundled spacers using A356 and vacuum die casting has resulted in parts with a tensile strength of at least 250 MPa and an elongation of no less than 7%. This improvement has laid a foundation for enhancing the operational reliability of existing overhead transmission line fittings.
Anodizing Tungsten Foil with Ionic Liquids for Enhanced Photoelectrochemical Applications
Authors: Da Silva Elianny , Sánchez-García Ginebra , Pérez-Calvo Alberto , Fernández-Domene Ramón M. , Solsona Benjamin , Sánchez-Tovar Rita
Published: March 2024

This research examines the influence of adding a commercial ionic liquid to the electrolyte during the electrochemical anodization of tungsten for the fabrication of WO3 nanostructures for photoelectrochemical applications. An aqueous electrolyte composed of 1.5 M methanesulfonic acid and 5% v/v [BMIM][BF4] or [EMIM][BF4] was used. A nanostructure synthesized in an ionic-liquid-free electrolyte was taken as a reference. Morphological and structural studies of the nanostructures were performed via field emission scanning electron microscopy and X-ray diffraction analyses. Electrochemical characterization was carried out using electrochemical impedance spectroscopy and a Mott–Schottky analysis. From the results, it is highlighted that, by adding either of the two ionic liquids to the electrolyte, well-defined WO3 nanoplates with improved morphological, structural, and electrochemical properties are obtained compared to samples synthesized without ionic liquid. In order to evaluate their photoelectrocatalytic performance, the samples were used as photocatalysts to generate hydrogen by splitting water molecules and in the photoelectrochemical degradation of methyl red dye. In both applications, the nanostructures synthesized with the addition of either of the ionic liquids showed a better performance. These findings confirm the suitability of ionic liquids, such as [BMIM][BF4] and [EMIM][BF4], for the synthesis of highly efficient photoelectrocatalysts via electrochemical anodization.
Comparative Study of the Influence of Heat Treatment on Fracture Resistance of Different Ceramic Materials Used for CAD/CAM Systems
Authors: Balladares Andrea Ordoñez , Abad-Coronel Cristian , Ramos Joao Carlos , Fajardo Jorge I. , Paltán Cesar A. , Martín Biedma Benjamín José
Published: March 2024

The aim of this study was to compare the influence of heat treatment on fracture resistance (FR) of different ceramic materials used for CAD/CAM systems. Methods: Eighty monolithic restorations were designed using the same parameters and milled with a CAD/CAM system (CEREC SW 5.0, PrimeMill, Dentsply-Sirona™, Bensheim, Germany), forming five study groups: Group 1 (n = 10), CEREC Tessera (Dentsply-Sirona™, Bensheim, Germany) crystallized (CCT), Group 2 (n = 10), CEREC Tessera uncrystallized (UCT), Group 3 (n = 20), Emax-CAD (Ivoclar Vivadent, Schaan, Liechtenstein) (CEC), Group 4 (n = 20), Vita Suprinity (Vita Zahnfabrik, Bad Säckingen, Germany) (CVS), and Group 5 (n = 20) Cameo (Aidite, Qinhuangdao, China) (CC). Results: The average FR was similar for CCT, CC, and CEC at above 400 N, while CVS and UCT had the lowest values at 389,677 N and 343,212 N, respectively. Conclusion: Among the three ceramic materials that exhibited an FR above 400 N, CCT was considered the first recommended choice for CAD/CAM systems. This material not only demonstrated the highest FR but also exhibited outstanding consistency in the related measurements without the presence of outliers. Although the CC material showed high FR, its high dispersion revealed inconsistencies in the repetitions, suggesting caution in its use.
In-Depth Insight into the Effects of Steel Slag and Calcium Hydroxide on the Properties of a Fly Ash–Red Mud Geopolymer
Authors: Wang Penghuai , Chen Ping , Ming Yang , Li Qing , Dong Xuanxuan
Published: March 2024

The low mechanical strength of a low-calcium fly ash (FA)–red mud (RM) geopolymer severely limits its application. Steel slag (SS) and Ca(OH)2 can provide calcium and alkali for the hydration process of a low-calcium FA-based geopolymer. In this study, SS was used to replace part of the RM, and Ca(OH)2 was introduced. The effects of SS and Ca(OH)2 on the properties of the FA-RM geopolymer were investigated. The experimental results show that SS promoted the matrix to generate more C(N)-A-S-H and C-S-H gels and optimized the pore structure, thereby improving the mechanical properties of the FA-based geopolymer. The addition of 4 wt.% Ca(OH)2 increased the hydration products of the FA-based geopolymer, the microstructure was denser, and the mechanical properties were significantly improved. The 28 d compressive strength of the FA-based ternary composite geopolymer prepared by replacing part of the RM with SS and adding Ca(OH)2 reached 30.6 MPa, which provided an experimental basis for the resource utilization of various bulk solid wastes.
Mechanical Behavior and Microstructure Evaluation of Quicklime-Activated Cement Kiln Dust-Slag Binder Pastes
Authors: Hu Minhui , Dong Tianwen , Cui Zhenglong , Li Zhuo
Published: March 2024

Cement kiln dust (CKD) is a by-product of cement production, which has the shortcomings of low utilization and high-temperature activation. This study combined CKD and slag as precursors for preparing pastes through quicklime activation under ambient conditions. The effects of quicklime and CKD content on the workability (flowability and setting time), macro-mechanical properties, and micro-structure of the CKD-slag binders were analyzed. The experimental results showed that the rapid precipitation of Ca2+, Si4+, and Al3+ ions from the CKD provided more nucleation sites for the formation of calcium aluminosilicate hydrate (C-(A)-S-H) gel and enhanced the reactivity of the binder system under the influence of the activator (CaO). The specimens had the highest unconfined compressive strength (UCS) (24.6 MPa) after 28 days with 10% quicklime content and 60% CKD content; scanning electron microscopy with energy-dispersive X-ray (SEM-EDX) analysis showed that the Ca/Si ratio of the C-(A)-S-H gel was minimized, leading to a denser microstructure and better binding ability under this mixing proportion. Therefore, this study may provide novel binder materials with a high proportion of CKD under ambient conditions.
Experimental Study of a Representative Sample to Determine the Chemical Composition of Cast Iron
Authors: Laubertova Martina , Ruzickova Silvia , Trpcevska Jarmila , Briancin Jaroslav
Published: March 2024

In metallurgical practice, the material is considered of adequate quality if it meets the customer’s expectations. It is necessary to take representative samples and perform quality testing to avoid financial and intangible losses. Sample contamination and matrix and surface quality play a significant role in the accuracy of chemical analyses. The purpose of this paper is to point out the advantages of specific methods of taking samples, such as immersion and spoon sampling of molten metal, and, in the experimental part, to assess the impacts of factors affecting the quality of the sampling. The influence of time of final sampling on determining the true amount of magnesium during a single melt and the influence of duration of mixing of molten cast iron on the accuracy of chemical analysis of the control sample were investigated. It is important that the time between the modification and casting of the liquid cast iron from the casting ladle be as short as possible. This is because the magnesium burns out and thus the chemical analysis of the sample taken is not accurate. Another important factor is ensuring the melt before sampling is homogenized and has the minimum prescribed temperature (1420 °C). Increasing sample collection time will cause changes in its chemical composition.
Preparation of Ce-Doped Gd3(Al, Ga)5O12 Nanopowders via Microwave-Assisted Homogenization Precipitation for Transparent Ceramic Scintillators
Authors: Liu Min , Zhang Yansen , Hu Song , Zhou Guohong , Qin Xianpeng , Wang Shiwei
Published: March 2024

Ce-doped gadolinium gallium aluminum oxide (Ce: GGAG) precursors were first prepared by the microwave-assisted homogeneous precipitation method (MAHP). Thermal gravity-differential thermal analysis (TG-DTA), X-ray diffraction (XRD), specific surface area analysis (BET) and field emission scanning electron microscopy (FE-SEM) were employed to investigate the crystal structure, phase evolution and morphologies of the Ce: GGAG precursors and powders. The influence of Ga ion concentration in the salt solution on the properties of Ce: GGAG powders was investigated. All the precursors were transformed into single-phase GGAG after being calcined at 950 °C in a furnace for 3 h. Monodispersed Ce: GGAG powders were obtained as the Ga ion concentration was lower than 0.06 mol/L. Single-phase and dense Ce: GGAG ceramics were obtained after sintering at 1600 °C in a flowing oxygen atmosphere for 10 h. Specifically, the Ce: GGAG ceramic reached its maximum density of ~6.68 g/cm3, which was close to its theoretical density of 6.70 g/cm3, and exhibited the highest optical transmittance of 65.2% at 800 nm after hot isostatic pressing sintering (HIP) as the Ga ion concentration was 0.02 mol/L. The decay time and light yield of the GGAG ceramic were 35 ns and 35,000 ± 1250 ph/MeV, respectively, suggesting that Ce: GGAG ceramics prepared using MAHP-synthesized nanopowders are promising for scintillation applications.
The Performance of Niobium-Microalloying Ultra-High-Strength Bridge Cable Steel during Hot Rolling
Authors: Zhou Jie , Yu Zhichao , Chen Jiahui , Wu Sheng , Wu Kaiming , Pan Libo
Published: March 2024

This study focuses on exploring the effects of niobium (Nb)-microalloying on the properties of steel for ultra-high-strength bridge cables during hot-rolling processes. We employed a combination of dual-pass compression tests, stress–strain curve analysis, and Electron Backscatter Diffraction (EBSD) techniques to investigate the influence of Nb-microalloying on the static recrystallization behavior and grain size of the steel. The key findings reveal that Nb-microalloying effectively inhibits static recrystallization, particularly at higher temperatures, significantly reducing the volume fraction of recrystallized grains, resulting in a finer grain size and enhanced deformation resistance. Secondly, at a deformation temperature of 975 °C, Nb-containing steel exhibited finer grain sizes compared to Nb-free steel when held for 10 to 50 s; however, the grain size growth accelerated when the hold time exceeded 50 s, likely linked to the increased deformation resistance induced by Nb. Lastly, this research proposes optimal hot-rolling process parameters for new bridge cable steel, recommending specific finishing rolling temperatures and inter-pass times for both Nb-containing and Nb-free steels during the roughing and finishing stages. This study suggests optimal hot-rolling parameters for both Nb-containing and Nb-free steels, providing essential insights for improving hot-rolling and microalloying processes in high-carbon steels for bridge cables.
Study on Flowability Regulation of Vacuum Gas-Atomized Fe-Cr-Ni-W-B Spherical Powder
Authors: Yu Pengfei , Li Jun , Liu Ying
Published: March 2024

High-quality Fe-Cr-Ni-W-B spherical powder is crucial for the powder metallurgy preparation of high-strength and tough Fe-Cr-Ni-W-B alloys. In this study, the controlled preparation of high-quality Fe-Cr-Ni-W-B spherical powder was achieved using the vacuum gas atomization method. The effects and mechanisms of atomization gas pressure, the melt nozzle inner diameter, and heat treatment temperature on the microstructure and flowability of Fe-Cr-Ni-W-B spherical powder were systematically investigated. By optimizing process parameters, spherical Fe-Cr-Ni-W-B powder with a sphericity of 95.1% and a flowability of 15.88 s/50 g was obtained, laying the foundation for the powder metallurgy preparation of high-strength and tough Fe-Cr-Ni-W-B alloys.
Reinvestigating the Kinetic Model for the Suspended Sediment Concentration in an Open Channel Flow
Authors: Dalla Via Marco , Absi Rafik
Published: March 2024

The prediction of sediment transport, related to different environmental and engineering problems, requires accurate mathematical models. Most available mathematical models for the concentrations of suspended sediments are based on the classical advection diffusion equation, which remains not efficient enough to describe the complete behavior related to sediment–water two-phase flows and the feedback between the turbulent unsteady flow and suspended sediments. The aim of this paper is to reinvestigate the kinetic model for turbulent two-phase flows, which accounts for both sediment–turbulence interactions and sediment–sediment collisions. The present study provides a detailed and rigorous derivation of the kinetic model equations, clarifications about the mathematical approach and more details about the main assumptions. An explicit link between the kinetic model and the classical advection diffusion equation is provided. Concentration profiles for suspended sediments in open channel flows show that the kinetic model is able to describe the near-bed behavior for coarse sediments.
Starlike Functions of the Miller–Ross-Type Poisson Distribution in the Janowski Domain
Authors: Murugusundaramoorthy Gangadharan , Güney Hatun Özlem , Breaz Daniel
Published: March 2024

In this paper, considering the various important applications of Miller–Ross functions in the fields of applied sciences, we introduced a new class of analytic functions f, utilizing the concept of Miller–Ross functions in the region of the Janowski domain. Furthermore, we obtained initial coefficients of Taylor series expansion of f, coefficient inequalities for f−1 and the Fekete–Szegö problem. We also covered some key geometric properties for functions f in this newly formed class, such as the necessary and sufficient condition, convex combination, sequential subordination and partial sum findings.
Impact of Demographic Developments and PCV13 Vaccination on the Future Burden of Pneumococcal Diseases in Germany—An Integrated Probabilistic Differential Equation Approach
Authors: Sarajan Myka Harun , Mahreen Kahkashan , Vanella Patrizio , Kuhlmann Alexander
Published: March 2024

Streptococcus pneumonia is the primary cause of morbidity and mortality in infants and children globally. Invasive pneumococcal disease (IPD) incidence is affected by various risk factors such as age and comorbidities. Additionally, this bacterium is a major cause of community-acquired pneumonia (CAP), leading to higher rates of hospitalization, especially among older adults. Vaccination with pneumococcal conjugate vaccines (PCVs) has proven effective, but the demographic transition in Germany poses a challenge. This study introduces a novel stochastic approach by integrating a population forecast model into a transmission dynamic model to investigate the future burden of pneumococcal diseases in three age groups (0–4, 5–59, and 60 and older). Our simulations, presented through mean predictions and 75% prediction intervals, indicate that implementing PCV13 (13-valent pneumococcal conjugate vaccine) until the year 2050 results in reduced cases of IPD and CAP in all age groups compared to scenarios without infant vaccination. However, cases with non-vaccine serotypes may persist at higher levels compared to scenarios without infant vaccination. Consequently, there may be a need for improvement in the current national vaccine policy, such as implementing the use of higher-valent PCVs and strengthening adult vaccination uptake.
Approximate Solution of PHI-Four and Allen–Cahn Equations Using Non-Polynomial Spline Technique
Authors: Haq Mehboob Ul , Haq Sirajul , Ali Ihteram , Ebadi Mohammad Javad
Published: March 2024

The aim of this work is to use an efficient and accurate numerical technique based on non-polynomial spline for the solution of the PHI-Four and Allen–Cahn equations. A recent discovery suggests that the PHI-Four equation focuses on its implications for particle physics and the behavior of scalar fields in the quantum realm. In materials science, ongoing research involves using the Allen–Cahn equation to understand and predict the evolution of microstructures in various materials as well as in biophysics. It depicts pattern formation in biological systems and the dynamics of spatial organization in tissues. To obtain an approximate solution of both equations, this technique uses forward differences for the time and cubic non-polynomial spline function for spatial descretization. The stability of the suggested technique is addressed using the von Neumann technique. Convergence test is carried out theoretically to show the order of convergence of the scheme. Some numerical tests are carried out to confirm accuracy and efficiency in terms of absolute error LR. Convergence rates for different test problems are also computed numerically. Numerical results and simulations obtained are compared with the existing methods.
Equivalent Condition of the Measure Shadowing Property on Metric Spaces
Authors: Miao Jie , Yang Yinong
Published: March 2024

The concept referred to as the measure shadowing property for a dynamical system on compact metric space has recently been introduced, acting as an extension of the classical shadowing property by using the property of the Borel measures on the phase space. In this paper, we extend the concept of the measure shadowing property of continuous flows from compact metric spaces to the general metric spaces and demonstrate the equivalence relation between the measure shadowing property and the shadowing property for flows on metric spaces via the shadowable points.
Some Properties of Generalized Apostol-Type Frobenius–Euler–Fibonacci Polynomials
Authors: Alatawi Maryam Salem , Khan Waseem Ahmad , Kızılateş Can , Ryoo Cheon Seoung
Published: March 2024

In this paper, by using the Golden Calculus, we introduce the generalized Apostol-type Frobenius–Euler–Fibonacci polynomials and numbers; additionally, we obtain various fundamental identities and properties associated with these polynomials and numbers, such as summation theorems, difference equations, derivative properties, recurrence relations, and more. Subsequently, we present summation formulas, Stirling–Fibonacci numbers of the second kind, and relationships for these polynomials and numbers. Finally, we define the new family of the generalized Apostol-type Frobenius–Euler–Fibonacci matrix and obtain some factorizations of this newly established matrix. Using Mathematica, the computational formulae and graphical representation for the mentioned polynomials are obtained.
Robust Transceiver Design for Correlated MIMO Interference Channels in the Presence of CSI Errors under General Power Constraints
Authors: Kang Jae-Mo , Lim Dong-Woo
Published: March 2024

In this paper, we consider a new design problem of optimizing a linear transceiver for correlated multiple-input multiple-output (MIMO) interference channels in the presence of channel state information (CSI) errors, which is a more realistic and practical scenario than those considered in the previous studies on uncorrelated MIMO interference channels. By taking CSI errors into account, the optimization problem is initially formulated to minimize the average mean square error (MSE) under the general power constraints. Since the objective function is not jointly convex in precoders and receive filters, we split the original problem into two convex subproblems, and then linear precoders and receive filters are obtained by solving two subproblems iteratively. It is shown that the proposed algorithm is guaranteed to converge to a local minimum. The numerical results show that the proposed algorithm can significantly reduce the sensitivity to CSI errors compared with the existing robust schemes in the correlated MIMO interference channel.
Maps on the Mirror Heisenberg–Virasoro Algebra
Authors: Guo Xuelian , Kaygorodov Ivan , Tang Liming
Published: March 2024

Using the first cohomology from the mirror Heisenberg–Virasoro algebra to the twisted Heisenberg algebra (as the mirror Heisenberg–Virasoro algebra module), in this paper, we determined the derivations on the mirror Heisenberg–Virasoro algebra. Based on this result, we proved that any two-local derivation on the mirror Heisenberg–Virasoro algebra is a derivation. All half-derivations are described, and as corollaries, we have descriptions of transposed Poisson structures and local (two-local) half-derivations on the mirror Heisenberg–Virasoro algebra.
Scalable Learning for Spatiotemporal Mean Field Games Using Physics-Informed Neural Operator
Authors: Liu Shuo , Chen Xu , Di Xuan
Published: March 2024

This paper proposes a scalable learning framework to solve a system of coupled forward–backward partial differential equations (PDEs) arising from mean field games (MFGs). The MFG system incorporates a forward PDE to model the propagation of population dynamics and a backward PDE for a representative agent’s optimal control. Existing work mainly focus on solving the mean field game equilibrium (MFE) of the MFG system when given fixed boundary conditions, including the initial population state and terminal cost. To obtain MFE efficiently, particularly when the initial population density and terminal cost vary, we utilize a physics-informed neural operator (PINO) to tackle the forward–backward PDEs. A learning algorithm is devised and its performance is evaluated on one application domain, which is the autonomous driving velocity control. Numerical experiments show that our method can obtain the MFE accurately when given different initial distributions of vehicles. The PINO exhibits both memory efficiency and generalization capabilities compared to physics-informed neural networks (PINNs).
Developing New Fully Connected Layers for Convolutional Neural Networks with Hyperparameter Optimization for Improved Multi-Label Image Classification
Authors: Katona Tamás , Tóth Gábor , Petró Mátyás , Harangi Balázs
Published: March 2024

Chest X-ray evaluation is challenging due to its high demand and the complexity of diagnoses. In this study, we propose an optimized deep learning model for the multi-label classification of chest X-ray images. We leverage pretrained convolutional neural networks (CNNs) such as VGG16, ResNet 50, and DenseNet 121, modifying their output layers and fine-tuning the models. We employ a novel optimization strategy using the Hyperband algorithm to efficiently search the hyperparameter space while adjusting the fully connected layers of the CNNs. The effectiveness of our approach is evaluated on the basis of the Area Under the Receiver Operating Characteristic Curve (AUC-ROC) metric. Our proposed methodology could assist in automated chest radiograph interpretation, offering a valuable tool that can be used by clinicians in the future.
A Four-Variable Shear Deformation Theory for the Static Analysis of FG Sandwich Plates with Different Porosity Models
Authors: Alghanmi Rabab A. , Aljaghthami Rawan H.
Published: March 2024

This study is centered on examining the static bending behavior of sandwich plates featuring functionally graded materials, specifically addressing distinct representations of porosity distribution across their thickness. The composition of the sandwich plate involves a ceramic core and two face sheets with functionally graded properties. Mechanical loads with a sinusoidal distribution are applied to the sandwich plate, and a four-variable shear deformation theory is employed to establish the displacement field. Notably, this theory involves only four unknowns, distinguishing it from alternative shear deformation theories. Equilibrium equations are derived using the virtual work concept, and Navier’s method is applied to obtain the solution. The study addresses the impact of varying porosities, inhomogeneity parameters, aspect ratios, and side-to-thickness ratios on the static bending behavior of the sandwich plates. The influence of various porosities, inhomogeneity parameter, aspect ratio, and side-to-thickness ratio of the sandwich plates are explored and compared in the context of static bending behavior. The three porosity distributions are compared in terms of their influence on the bending behavior of the sandwich plate. The findings indicate that a higher porosity causes larger deflections and Model A has the highest central deflection. Adopting the four-variable shear deformation theory demonstrated its validity since the results were similar to those obtained in the literature. Several important findings have been found, which could be useful in the construction and application of FG sandwich structures. Examples of comparison will be discussed to support the existing theory’s accuracy. Further findings are presented to serve as benchmarks for comparison.
Induction of Autophagy by Extract from Corydalis heterocarpa for Skin Anti-Aging
Authors: Yang Kyeong Eun , Nam Soo-Bin , Lee Ga-Eun , Yang Gabsik , Lee Mee-Hyun , Bang Geul , Choi Jung Hoon , Cho Yong-Yeon , Lee Cheol-Jung
Published: March 2024

The extracts of Corydalis heterocarpa, a salt-tolerant plant, exhibit diverse physiological properties, including anti-inflammatory, anticancer, and antiadipogenic effects. However, the anti-aging effects of C. heterocarpa extract (CHE) on human skin cells have not yet been investigated. In the present study, we determined that CHE inhibited senescence-associated β-galactosidase (SA-β-gal)-stained senescent human dermal fibroblasts (HDFs). Furthermore, CHE markedly suppressed the expression of major regulatory proteins involved in senescence, including p53, p21, and caveolin-1. Interestingly, CHE promoted autophagic flux, as confirmed by the formation of microtubule-associated protein 1 light chain 3B (LC3B) puncta and lysosomal activity. Notably, using RNA sequencing (RNA-seq), we showed that CHE selectively regulated the gene expression of leucine-rich repeat and sterile alpha motif-containing 1 (LRSAM1), an important regulator of autophagy. The adenosine-monophosphate activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) pathway, which is essential for autophagy regulation, was also modulated by CHE. LRSAM1 depletion not only inhibited LC3B expression but also decreased the autophagy flux induced by CHE. Moreover, the knockdown of LRSAM1 suppressed the reversal of CHE-induced senescence in old HDFs. Collectively, our study has revealed the rejuvenating effects and molecular mechanisms of CHE, suggesting that CHE may be a promising anti-aging agent.
Isolation and Purification of Chitosan Oligosaccharides (Mw ≤ 1000) and Their Protective Effect on Acute Liver Injury Caused by CCl4
Authors: Wang Kai , Yu Dawei , Bai Yan , Cao Hua , Guo Jiao , Su Zhengquan
Published: March 2024

Chitosan oligosaccharides are the degradation products of chitin obtained from the shell extracts of shrimps and crabs. Compared with chitosan, chitosan oligosaccharides have better solubility and a wider application range. In this study, high-molecular-weight chitosan oligosaccharides (COST, chitosan oligosaccharides, MW ≤ 1000) were isolated and purified by a GPC gel column, and the molecular weight range was further reduced to obtain high-purity and low-molecular-weight chitosan (COS46). Compared with COST, COS46 is better at inhibiting CCl4-induced cell death, improving cell morphology, reducing ALT content, and improving cell antioxidant capacity. The effects of COST and COS46 on CCl4-induced acute liver injury were further verified in mice. Both COS46 and COST improved the appearance of the liver induced by CCl4, decreased the levels of ALT and AST in serum, and decreased the oxidation/antioxidant index in the liver. From the liver pathological section, the effect of COS46 was better. In addition, some indicators of COS46 showed a dose-dependent effect. In conclusion, compared with COST, low-molecular-weight COS46 has better antioxidant capacity and a better therapeutic effect on CCl4-induced acute liver injury.
Lower Arginine Bioavailability, Increased FeNO Levels, and Airway Resistance on Impulse Oscillometry Are Characteristics of Asthma in Children and Young Adults with Sickle Cell Disease
Authors: Ozhan Aylin Kont , Arikoglu Tugba , Er Melih , Unal Selma , Yıldırım Didem Derici , Erkasar Funda , Balcı Şenay , Tamer Lulufer , Kuyucu Semanur
Published: March 2024

Background and Objectives: Data on characteristics of asthma in children with sickle cell disease (SCD) is conflicting. Recently, the L-arginine pathway has gained attention in the pathogenesis of asthma and SCD. This study aimed to determine the distinctive clinical and laboratory features and the role of arginine metabolism in asthmatic children with SCD. Materials and Methods: A total of 52 children and adolescents with SCD, including 24 with asthma (SCD-A) and 28 without asthma (SCD-NA), and 40 healthy controls were included. A questionnaire, atopy tests, fractional exhaled nitric oxide (FeNO), and lung function tests were employed. Serum metabolites of the arginine pathway were measured. The results of the three groups were compared. Results: The demographic characteristics and atopy markers of the three groups were similar. FEV1%, FEV1/FVC, MMEF%, and total lung capacity (TLC%) values of SCD-A patients were not significantly different from the SCD-NA group, but they were significantly lower than the values measured in the controls. FeNO values greater than 35 ppb were present only in the SCD-A group. In impulse oscillometry, median resistance values at 5 Hz (R5)% were higher in both SCD subgroups than in healthy controls (p = 0.001). The (R5-20/R5)% values were higher in the SCD-A group (p = 0.028). Serum arginine levels and arginine bioavailability indices were significantly lower in the SCD-A group than in the SCD-NA group and healthy controls (p = 0.003 and p < 0.001). Conclusions: Asthma in children with SCD was not associated with atopy or low FEV1/FVC levels. However, lower arginine bioavailability and higher FeNO levels differentiated asthma in patients with SCD. High R5% and (R5-20/R5)% values indicated increased airway resistance in SCD, with a predominance of small airway disease in asthmatics.
Hepatic Hemangioma: Review of Imaging and Therapeutic Strategies
Authors: Kacała Arkadiusz , Dorochowicz Mateusz , Matus Iwona , Puła Michał , Korbecki Adrian , Sobański Michał , Jacków-Nowicka Jagoda , Patrzałek Dariusz , Janczak Dariusz , Guziński Maciej
Published: March 2024

Hepatic hemangiomas are the most common benign liver tumors. Typically, small- to medium-sized hemangiomas are asymptomatic and discovered incidentally through the widespread use of imaging techniques. Giant hemangiomas (>5 cm) have a higher risk of complications. A variety of imaging methods are used for diagnosis. Cavernous hemangioma is the most frequent type, but radiologists must be aware of other varieties. Conservative management is often adequate, but some cases necessitate targeted interventions. Although surgery was traditionally the main treatment, the evolution of minimally invasive procedures now often recommends transarterial chemoembolization as the treatment of choice.