bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of chemical modification using glyoxylic acid on the stability of α-amylase from Aspergillus fumigatus
Authors: Yandri Yandri , Noviani Dwi , Ropingi Hendri , Suhartati Tati , Irawan Bambang , Hadi Sutopo
Published: February 2025

In this present work, α-amylase isolated from Aspergillus fumigatus was successfully modified using glyoxylic acid. The enzyme was isolated through centrifugation and purified using (NH4)2SO4 salt deposition and dialysis. The purified α-amylase exhibited a purity level 17.79 times higher than that of the crude extract. The study also found that the optimum pH for α-amylase was 5.0, while for the α-amylase/glyoxylic acid an optimum pH of 5.5 was observed. Both the native and modified α-amylase showed an optimum temperature of 55 °C. The native α-amylase has the K
M values of 11.55 mg mL−1 substrate and V
max of 10.76 mol mL−1 min−1. In contrast, the α-amylase/glyoxylic acid complex has the K
M values ranging from 14.67 to 16.73 mg mL−1 substrate and V
max ranging from 7.07 to 9.32 mol mL−1 min−1. The residual activity of the native enzyme after incubation for 100 min at 60 °C was 9.34 %, while the modified enzyme exhibited residual activities ranging from 28 to 59 %. The ΔG
i for the native α-amylase was 104.333 kJ mol−1, while for the modified enzyme, the values in the range of 105.825–106.314 kJ mol−1 were found. Another important finding is significantly higher stability of the modified enzyme compared to the native enzyme, α-amylase, as evidenced by an increase in half-life (t
½) ranging from 1.71 to 2.05 times.
The Digital History Project Repertorium Academicum Germanicum (RAG) and Its Knowledge-Driven Approach to Prosopography
Authors: Gubler Kaspar
Published: February 2025

This article aims to offer an overview of the research project Repertorium Academicum Germanicum (RAG), focusing both on its methodological and technical aspects and demonstrating data analysis methods using the example of Hungarian students listed in the RAG database. The RAG is a digital historical research project focusing on scholars and students from the Holy Roman Empire (HRE) between 1250 and 1550, initiated in 2001. It stands as a pioneering project in digital history and prosopography, relying on meticulous data collection from university registers and supplementary sources. The RAG explores research questions concerning the medieval roots and foundations of modern knowledge societies, focusing on the work of scholars and the development of knowledge, particularly in relation to the academisation of European society. While primarily focused on the HRE, the RAG also serves as a valuable resource for studying Hungarian students. Compiling the group of Hungarian scholars within the RAG involves identifying scholars based on their geographical origin, yielding around 1045 scholars up to 1550, with almost a thousand within the timeframe of 1526. Alternative methods, such as examining source texts or Hungarian nation affiliations at the University of Vienna, supplement this process. Despite being smaller in scope compared to databases like the Repertorium Academicum Hungariae (RAH), the RAG provides valuable insights.
Análisis de las estrategias de comunicación digital de las páginas web de los museos más visitados de Europ
Authors: Tejedor Santiago , Romero-Rodríguez Luis M. , Rull-Ribó David , Hita Elena
Published: February 2025

Introducción: La redefinición de las estrategias de comunicación de los museos, especialmente en la arena digital, se ha convertido en un reto urgente. Este estudio presenta una investigación descriptiva, explicativa y exploratoria sobre los sitios web de los 20 museos más visitados de Europa. Metodología: Concibiendo las páginas web como el epicentro de la estrategia de comunicación corporativa de los museos, este estudio aplicó una ficha de análisis basada en seis variables y organizada en torno a 62 categorías temáticas. Resultados: Esta investigación destaca el crecimiento de los contenidos sonoros e informativos, al tiempo que detecta una menor apuesta por los desarrollos inmersivos y los contenidos «aumentados». Conclusión: Existe una tendencia a la mediatización de los procesos siguiendo rutinas propias de los cibermedios.
El uso de IA en la creación de contenidos publicitarios transmedia. El caso del sector artístico
Authors: Gómez-Domínguez María
Published: February 2025

Introducción: Este estudio analiza el uso de la inteligencia artificial (IA) en campañas publicitarias transmedia en el ámbito artístico, centrándose en cómo museos y galerías están utilizando IA para crear narrativas interactivas y automatizadas que mejoren la experiencia de los usuarios a través de tecnologías inmersivas como la realidad aumentada (AR) y la realidad virtual (VR). El objetivo es evaluar el impacto de estas herramientas en la creación de contenidos personalizados y atractivos. Metodología: Se realizó una revisión sistemática de la bibliografía sobre IA en publicidad transmedia y se analizaron casos de estudio de museos y galerías que incorporaron IA en plataformas como redes sociales, AR y VR. Los principales enfoques fueron la identificación de factores clave, la definición de pasos de actuación y la detección de elementos replicables. Resultados: Los hallazgos revelan que la IA ha incrementado la participación de los usuarios al personalizar experiencias y adaptar narrativas publicitarias. No obstante, surgieron desafíos relacionados con los límites éticos de la automatización y la posible pérdida de control creativo humano. Discusión: Aunque la IA demuestra ser un elemento indispensable en la publicidad transmedia, es esencial equilibrarla con la creatividad humana para garantizar campañas auténticas y significativas. Además, se deben abordar riesgos éticos y establecer fronteras claras en su implementación. Conclusiones: La IA tiene un gran potencial para transformar la publicidad transmedia en el sector artístico, pero su implementación requiere una gestión cuidadosa para preservar la creatividad humana y asegurar que las experiencias sean inclusivas y genuinas para el público.
Democracia e governança na Guiné-Bissau
Authors: Djanté Mamudo
Published: February 2025

Desde a sua independência, a Guiné-Bissau tem sido marcada por ciclos de instabilidade política e desafios de governança ao longo de sua trajetória democrática. Este país africano conheceu inúmeros golpes de Estado e uma série de tentativas de subversão de ordem constitucional, causadas por crises políticas internas no seio dos diferentes partidos políticos e conflitos entre titulares de órgãos de poder, que dificultaram a instalação de instituições democráticas sólidas e da consolidação de governos democraticamente estabelecidos. Portanto, este artigo objetiva fazer uma análise sobre a democracia e à governança na Guiné-Bissau, trazendo algumas considerações no período antes da abertura democrática de 1991, visto que o país passou por diferentes estágios políticos com períodos de governo civil e militar. Os constantes sobressaltos ao poder na Guiné-Bissau parecem ser empecilhos para a consolidação democrática, e um dos principais fatores que impedem o país de criar mecanismos para uma boa governação e o lançamento do seu desenvolvimento econômico e social. Também, constata-se que o fraco funcionamento das instituições do Estado afeta sobremaneira a implementação de projetos de governos afirmados ao longo dos tempos. Por outro lado, o atual chefe de Estado está a transformar substancialmente o sistema político do país em um regime autoritário. 
 
Palavras-Chave: Democracia; Governança; Política; Eleições; Guiné-Bissau.
Neuroendocrine control of synaptic transmission by PHAC-1 inC. elegans.
Authors: Stratigi Aikaterini , Soler-García Miguel , Krout Mia , Shukla Shikha , De Bono Mario , Richmond Janet E. , Laurent Patrick
Published: February 2025

A dynamic interplay between fast synaptic signals and slower neuromodulatory signals controls the excitatory-inhibitory (E/I) balance within neuronal circuits. The mechanisms by which neuropeptide signaling is regulated to maintain E/I balance remain uncertain. We designed a genetic screen to isolate genes involved in the peptidergic maintenance of the E/I balance in theC. elegansmotor circuit. This screen identified theC. elegansorthologs of the presynaptic phosphoprotein Synapsin (snn-1) and the Protein Phosphatase 1 (PP1) regulatory subunit PHACTR1 (phac-1). We demonstrate that bothphac-1andsnn-1alter the motor behavior ofC. elegans, and genetic interactions suggest that SNN-1 contributes to PP1-PHAC-1 holoenzyme signaling.De novovariants of human PHACTR1, associated with early-onset epilepsies (DEE70), when expressedin C. elegansresulted in constitutive PP1-PHAC-1 holoenzyme activity. Unregulated PP1-PHAC-1 signaling alters the Synapsin and Actin cytoskeleton and increases neuropeptide release by cholinergic motor neurons, which secondarily affects the presynaptic vesicle cycle. Together, these results clarify the dominant mechanisms of action of the DEE70 alleles and suggest that altered neuropeptide release may alter E/I balance in DEE70.

Significance StatementAlterations of the excitatory-inhibitory (E/I) balance within neuronal circuits contribute to seizures. Early-onset epilepsies are associated with 4 variants of human PHACTR1 (called DEE70). In a genetic screen designed to isolate genes involved in the maintenance of the E/I balance by peptidergic neuromodulators, we identified theC. elegansorthologs of PHACTR1 and of Synapsin. When introduced inC. elegans,the DEE70-associated variants reduced the E/I balance in motor circuits. Our results suggest that DEE70 variants induce the constitutive activity of an holophosphatase formed by PHACTR1. The constitutive holophosphatase signaling alters the Synapsin and Actin cytoskeleton and increases neuropeptide release which secondarily decreases E/I balance in circuits.
Malarial pigment-induced lipoperoxidation, inhibited motility and decreased CCR2 and TNFR1/2 expression on human monocytes
Authors: Skorokhod Oleksii , Barrera Valentina , Valente Elena , Ulliers Daniela , Uchida Koji , Schwarzer Evelin
Published: February 2025

Objective

Malaria remains an important life-threatening disease that provokes a complex immune response, marked by an initial immune boost followed by long-term suppression, warranting further study. One of the manifestations of compromised immune response is co-infections, which are frequently reported in malaria patients and post-malaria convalescent individuals. Monocyte motility is a crucial step in immune cell recruitment, but this process is not fully efficient in malaria. Malarial pigment hemozoin, avidly phagocytosed by monocytes, inhibits important monocyte functions through lipoperoxidation.

Methods

4-Hydroxynonenal (4-HNE) adducts were detected on primary human monocytes by fluorescent microscopy, and CCR2 and TNFR1/2 receptors by flow cytometry. A two-dimensional migration microfluidic assay was applied for studying monocyte motility.

Results

We show here that, following hemozoin ingestion, monocyte motility is inhibited. This is accompanied by a 2.4 ± 0.3-fold increase of the adducts of the lipoperoxidation product 4-HNE with monocyte proteins. Reduction of cell directional motility by 3.2 ± 0.6 times in response to MCP-1 and by 3.8 ± 1.1 times in response to TNF-α is observed alongside a decrease in CCR2 expression by 55 ± 8%, TNFR1 (CD120a) expression by 79 ± 4% and TNFR2 (CD120b) expression by 58 ± 7%.

Conclusions

The low availability and potential malfunction of these important chemotactic receptors could be proposed as an additional mechanism for the poor immune response in malaria. Therapeutic relevance could be found in interventions aimed at regulating damaged or downregulated receptors and the application of antioxidants or other reagents to contrast protein addition of free 4-HNE.

Significance statement

The study deepened our knowledge about lipid peroxidation processes, which are related to infectious diseases and immunity. Observed impaired immune motility and collapse of receptors could explain immunosuppression manifestations and co-infections in malaria and other diseases accompanied by oxidative stress.
FECAL MICROBIOTES TRANSPLANTATION TECHNOLOGIES: MEDICAL, BIOTECHNOLOGICAL AND REGULATORY ASPECTS
Authors:   Institute of Plant Physiology and Genetics of the National Academy of Sciences of Ukraine, Kyrychenko O. V.
Published: February 2025

The effectiveness of the soybean plants spraying with the soybean seed lectin solution during vegetation (against the background of seed inoculation with nodule bacteria and without seed inoculation), as well as the effectiveness of the winter wheat plants spraying with lectin-bacterial composition in green-house and field experiments was investigated respectively. It was found that spraying of soybeans in the phase of two trifoliate leaves development with a specific lectin against the background of pre-sowing seed inoculation with rhizobia caused a significantly positive effect on the functional activity of the symbiotic apparatus. The nitrogen-fixing activity of the rhizosphere microbiota remained unchanged, which may indicate the vector of lectin action when sprayed through the plant. At the same time, the activation of plants vegetative growth was noted, which was maximally manifested by the height of their above ground part. The activity of exogenous sprayed lectin was less pronounced on the background of seed inoculation with rhizobia compared to non-inoculated plants. Plants spraying with soybean lectin against the background of seed inoculation provided an increase in harvest compared to non-inoculated control by 2.13 g/plant, but by the factor of lectin action this increase was only 0.19 g/plant and was insignificant. Non-inoculated soybean plants when sprayed with lectin formed a harvest that was significantly higher (by 0.64 g/plant) than that of plants in the absence of lectin. At this, the increase by the factor of lectin action was 22%. The spraying of winter wheat plants in the phase of mass spring germinations with the Azolec preparation (without pre-sowing seed inoculation) contributed to a significant increase in harvest by 1.6 c/ha. Therefore, the application of soybean and wheat plants spraying, respectively, with soybean seed lectin and lectin-bacterial Azolec preparation (wheat lectin),without involving pre-sowing seed inoculation, provided a greater degree of plants productive potential realization compared to control (without pre-sowing seed inoculation and plants spraying during vegetation).
Pediatrician Work Hours: 2013–2022
Authors: Cull William L. , Frintner Mary Pat , Kist Tylar W. , Freed Gary L. , Byrne Bobbi J.
Published: February 2025

OBJECTIVE

To examine individual variation in total and direct patient care work hours annually across a decade and identify associations of work hours with pediatrician characteristics and measures of work-life balance.

METHODS

Using data from the American Academy of Pediatrics Pediatrician Life and Career Experience Study (PLACES), a national longitudinal study, we examined total work and direct patient care hours reported by the same pediatricians each year, 2013–2022. Yearly participation ranged from 75% to 94%. We examined work-hour patterns using mixed-effects linear regression for longitudinal data. We also developed pediatrician profiles based on work hours and direct patient care time and explored associations with multiple measures of work-life balance.

RESULTS

Analyses included 12 864 observations from 1696 pediatricians. Mean hours per week across years were 42.8 for total and 33.3 for direct patient care work. A mixed-effects model examined total work hours. The largest associations showed men working more than women (B = 7.22; 95% CI, 6.04–8.39) and subspecialists from large subspecialties working more than general pediatricians (B = 7.20; 95% CI, 6.11–8.29). There was a slight decrease in total hours found across years (B = −0.12; 95% CI, −0.21 to −0.03). Pediatricians who worked more hours reported lower work-life balance. Pediatricians working a greater portion of their time in direct patient care did not report worse work-life balance.

CONCLUSIONS

Direct patient care made up three-fourths of total work hours, and pediatricians reported a slight annual decrease in hours worked. Men, subspecialists, and hospitalists were likely to work more hours, and higher work hours were negatively associated with work-life balance.
Unveiling floristic diversity in the High Atlas: Insights from a protected reserve in a global Mediterranean biodiversity hotspot
Authors: Elgadi S. , Zine H. , Dallahi Y. , Ouhammou A.
Published: February 2025

Plant species represent a hierarchical expression of vegetation, influenced by various environmental factors. With the growing awareness of the importance of ecological restoration and conservation, there is an increasing need to study and understand flora, its species composition, and its distribution to facilitate preservation and conservation efforts. This study aimed to investigate the floristic composition, plant diversity, and provide a comprehensive phyto-ecological analysis of the Amassine Reserve within the Toubkal National Park in Morocco. To achieve this, quantitative ecological techniques were employed to sample vegetation. In total, 154 phyto-ecological surveys were conducted, recording 116 vascular plant species, which belong to 101 genera and 40 different families. Asteraceae represented 16.2% of the species, followed by Lamiaceae and Leguminosae, each represent 7.7% of the total flora. The phytoecological analysis combined with principal correspondence analysis of the floristic composition revealed four distinct plant formations: Franken iaceae , newly characterized shrub stands of saline areas, Tetraclinaie , Juniperaie, and holm o ak plant stand. Each of these plant formations is described by its geographical distribution, its floristic composition and its ecological conditions. This study pr o vides crucial baseline data of the flora of this area. The findings offer a valuable resource for stakeholders involved in decision-making and the development of effective conservation strategies for this protected area.
Feeding ecology of Tropidophoxinellus callensis (Cyprinidae) in Algeria
Authors: Tababouchet M. , Mimoune N. , Marniche F. , Huyghe C. E. T. , Bougaham A. F.
Published: February 2025

Understanding species diet is crucial for comprehending ecosystem functions and trophic dynamics within food webs. The Maghreb b leak Tropidophoxinellus callensis (Guichenot, 1850 ) ( Cypriniformes, Cyprinidae) is an endemic fish species with populations isolated in Algeria and Tunisia. Unlike other species within the genus, ecological studies on the Maghreb b leak, particularly regarding its diet, are lacking. This study analyzed the diet composition of the Maghreb bleak over an annual cycle in northeastern Algeria. Diet analysis was conducted by examining the contents of 212 digestive tracts collected during seasonal sampling from February to September 2023. The diversity of the Maghreb bleak 's diet was assessed based on the presence and abundance of each prey, differentiating between terrestrial and aquatic prey. Additionally, Costello’s graphical method was utilized to evaluate potential prey and feeding strategies. Results indicate that insects (relative abundance = 86.1%) were more prevalent in the diet compared to plant material (relative abundance = 7.1%). The diet composition was more diverse in summer (Shannon-Weaver index H' = 4.43) and less diverse in spring (Shannon-Weaver index H' = 1.04). The Maghreb bleak exhibits a diverse diet with an omnivorous feeding strategy. The main prey and their abundance varied seasonally, with a consistent preference for dipteran larvae, namely, Chironomus sp. and Simuliidae sp. and plant material of Alnus glutinosa as predominant prey items throughout the year. The species also demonstrated opportunistic feeding behavior when these primary prey types were less abundant. These findings provide significant insights into the feeding ecology of th e Maghreb bleak , with implications for understanding its role in the ecosystem and infor m ing conservation efforts.
Caracterización morfológica de líneas avanzadas de chiles (Capsicum annuum L.) del centro de México
Authors: González-Pérez Enrique , Villalobos-Reyes Salvador , Núñez-Colin Carlos Alberto , Canul-Ku Jaime
Published: February 2025

Introducción. De las cinco especies cultivadas de chile Capsicum annuum L. es la más importante en el mundo, con gran demanda en la industria de alimentos, medicina, cosmetología, entre otras. México tiene la mayor diversidad de tipos cultivados, entre los que destacan jalapeño, guajillo, ancho, serrano y habanero. No obstante, hay agricultores que siembran materiales nativos que es necesario estudiar y preservar, como son mulato y chilaca. De algunos tipos como chilaca no existen cultivares comerciales mejorados, por lo que, los productores dependen de la semilla que producen. Objetivo. Caracterizar morfológicamente líneas avanzadas de diferentes tipos de C. annuum procedentes del centro de México. Materiales y métodos. El trabajo se llevó a cabo en los ciclos primavera verano 2022 y 2023, en el Campo Experimental Bajío, Celaya, Guanajuato, México. En 32 líneas avanzadas de ocho tipos de C. annumm, se evaluaron 42 caracteres con base en las directrices de la UPOV (Unión Internacional para la Protección de las Obtenciones Vegetales) y de la guía del IPGRI (Instituto Internacional de Recursos Genéticos). Los datos obtenidos fueron analizados mediante estadística descriptiva y sometidos a un análisis de conglomerados y de correspondencias. Resultados. La variación morfológica mostró que quince caracteres de planta, hoja y fruto fueron determinantes para diferenciar tipos y líneas de chile. Que con base en caracteres similares fueron ubicados en cinco grupos con el análisis clúster, donde los grupos I y III fueron conformados por tres tipos de chile y seis caracteres presentaron los eigenvectores positivos más altos. Conclusiones. La diversidad observada reveló caracteres morfológicos determinantes para diferenciar tipos y líneas de chiles, que sin duda deben concluir su proceso de mejora genética.
Data base of Age, sex and adiposity correlates of physical fitness in Costa Rican police academy cadets
Authors: Cervantes-Sanabria Jorge , Camacho-Sánchez Gerald , Hernández-Elizondo Jessenia , Carazo-Vargas Pedro , Brazo-Sayavera Javier , Castillo-Hernández Isaura M. , Salicetti-Fonseca Alejandro
Published: February 2025

This study had the following objectives: (i) to characterize pre-academy physical fitness, (ii) to analyze differences by age and sex, and (iii) to examine the associations between body fat percentage (BC%) and physical fitness in Costa Rican police cadets. A total of 393 cadets participated (age = 24.98 ± 4.65 years, weight = 72.78 ± 12.39 kg, height = 1.70 ± 0.09 m). Data were stratified into groups of 20-29 and 30-39 years and analyzed by sex and BC%. The tests were performed between 1 and 3 weeks during the basic training, evaluating body composition, grip strength, flexibility (S&R), vertical jump (VJ), agility (Illinois test), speed (30 m), anaerobic (300 m) and aerobic (2.4 km) capacity. Physical fitness varied by sex (p < 0.05), except for BMI and S&R. In men, each 1% increase in body fat (%) was associated with a loss of +0.034 s in agility (p = 0.004), +0.025 s in 30 m-sprint (p = 0.000), -0.20 kg, and -0.19 kg in grip strength (p = 0.010; p = 0.021), -0.64 cm in VJ (CMJ, p = 0.000), and -0.36 ml∙kg-1∙min-1 in VO2 max (p = 0.000). In women, it was associated with a loss of agility (+0.089 seconds, p = 0.000), VJ (CMJ = -0.39 cm, p = 0.000), 30 m sprint (+0.046 seconds, p = 0.000), 300 m sprint (+1.02 seconds; p = 0.000) and VO2 max (-0.33 ml∙kg-1∙min-1, p = 0.000). The police cadets showed a suboptimal initial physical condition. Age, sex, and body fat (%) are key factors that affect their performance.
The importance of approach the birth plan during prenatal care in basic health units Amazon
Authors: Cristiany Rodrigues Spinola Mara , Silva Oliveira Andressa , Jeanny Santos Marciel Thainá , Pantoja Campos Figueira Thayla , Almeida dos Santos Luana
Published: February 2025

Introduction: The Birth Plan (BP) is a document prepared by the pregnant Woman tongether with the professional who is accompanying her in her pregnancy process, Where you can list your choices regarding childbirth and first care for the newborn, providing her with the leading role and effective participation in all decisions regarding her pregnancy Objective:Report the importance of approaching the Birth Plan in basic units during prenatal care. Material and Methods: This is a field research with a qualitative approach, developed in 3 basic health units in the municipality of Santarem, inthe state of Pará. Results and discussions: During the interviews with the professionals, it was evident that although the nurses recognized the importance of the PP, the low adherence to the document is due to the professionals' lack of knowledge about it, as well as the lack of support from the municipal management and maternity hospitals in the continuity of care for this pregnant woman.Conclusion: The birth plan is an extremely important tool, but little used or commented on by the professionals who work directly in the program. Thus, there is an undeniable need for greater encouragement from professionals to adhere to this tool and for there to be effective support from maternity hospitals and from the municipal management itself, so that it is effective and continuity is given to the assistance to these pregnant women and, in this way, that they have their rights guaranteed and live a positive experience in relation to childbirth.
Teletrabajo y salud mental ocupacional: reflexiones sobre las implicancias de la pandemia de COVID-19
Authors: San Roman Lucioni Rodrigo , Arias Gallegos Walter Lisandro , Gallegos Miguel
Published: February 2025

Introducción: En el presente trabajo se reflexiona críticamente sobre las relaciones entre el teletrabajo y la salud ocupacional en el contexto de la pandemia de COVID-19, con especial énfasis en la región de América Latina. Particularmente, se analizan las implicancias del teletrabajo sobre la salud ocupacional y el síndrome de desgaste profesional. Proposición: Para ello, se revisan conceptos clave, se examinan los resultados de varias investigaciones efectuadas antes y después de la pandemia, y se presentan los aspectos benéficos del teletrabajo, así como sus limitaciones asociadas a diversos factores organizacionales. Argumentos para la discusión: A partir de la pandemia de COVID-19, la modalidad del teletrabajo se ha logrado imponer como régimen laboral para muchas personas, por ende, se requiere profundizar en sus repercusiones sobre la salud de los trabajadores. Conclusiones: El teletrabajo es una herramienta que favorece la flexibilidad, la autonomía y la productividad del trabajador. Sin embargo, deben existir políticas de protección al trabajador que minimicen el riesgo psicosocial y promuevan su salud y bienestar. También resulta necesario seguir estudiando los efectos del teletrabajo sobre la salud ocupacional, principalmente en la región de América Latina.
Fatores ligados à reação cutânea ao Paclitaxel no câncer de mama: análise sistemática nas bases Scopus e Web of Science
Authors: Santos Da Costa Flaviane , César Santos Da Silva Júlio , Rosa Magalhães Cristiane , Muniz Mello Cid Allan , Martins Salgado Do Amaral Athus
Published: February 2025

O câncer de mama, uma neoplasia do tecido mamário, sendo ele o segundo mais comum no mundo e o mais frequente em mulheres, apresenta um tratamento multifacetado, considerando diversos fatores associados à doença. Entre as opções terapêuticas, a quimioterapia desempenha um papel crucial, empregando uma variedade de linhagens e classes medicamentosas antineoplásicas, como os taxanos, exemplificado pelo paclitaxel (PTX). Reconhecido por sua eficácia em diferentes estágios de câncer, o PTX representa uma ferramenta valiosa no arsenal terapêutico. O impacto do câncer de mama na vida da paciente é significativo e multifacetado, amplamente influenciado pelos efeitos adversos que podem surgir durante o tratamento. Nesse contexto, a análise dos fatores associados às toxicidades cutâneas relacionadas ao PTX assume relevância. Uma revisão sistemática realizada nas bases de dados Scopus e Web of Science, abrangendo publicações dos últimos cinco anos (2019-2023), compreendeu 26 artigos que contribuíram para uma compreensão mais aprofundada do tema. Os resultados dessa análise destacam a necessidade premente de estudos futuros que se concentrem na identificação de pacientes com comorbidades pré-existentes, as quais podem influenciar significativamente o desfecho das reações adversas cutâneas. Tais investigações direcionadas são essenciais para otimizar a gestão dos efeitos colaterais do PTX e melhorar a qualidade de vida das pacientes submetidas ao tratamento do câncer de mama.
Salud psicológica en personas que sufrieron COVID-19: factores predictores
Authors: Angelucci Bastidas Luisa , Rondón Bernard José Eduardo
Published: February 2025

Introducción: Se estima que un porcentaje importante de las personas que padecieron COVID-19 puede continuar experimentando síntomas físicos y problemas de salud psicológica. Al respecto, diferentes factores psicosociales pueden explicar y predecir la salud de estas personas sobrevivientes. El objetivo del estudio fue conocer cómo el sexo, la edad, el nivel de instrucción, la pérdida de afectos cercanos por la enfermedad, la asistencia con oxígeno, el diagnóstico de enfermedad crónica pos-COVID-19 y las dificultades físicas y psicológicas afectan la salud psicológica de quienes padecieron COVID-19. Metodología: Se empleó un diseño prospectivo de grupo único en una muestra de 419 personas, hombres y mujeres, seleccionadas mediante un muestreo de tipo intencional. Se administró el Cuestionario de Salud General de Goldberg para medir disfunción social, ansiedad y depresión, en conjunto con un segundo instrumento diseñado para esta investigación, con el fin de evaluar variables sociodemográficas y variables relacionadas con la enfermedad. Resultados: El modelo que explica el mayor porcentaje de varianza fue el de disfunción social (16 %), en comparación con el de ansiedad y depresión (14 %). Por su parte, ser mujer (B = -.15; B = -.22), menor de edad (B = -.28; B = -.16) y presentar dificultades físicas (B = .17; B = .14) o psicológicas (B = .2; B = .13) predice mayor índice de disfunción social y de ansiedad y depresión. El diagnóstico de enfermedad crónica pos-COVID-19 (B = .11) predice sólo el nivel de ansiedad y depresión. Conclusión: En función de los resultados, se recomienda diseñar programas psicosociales para abordar la salud psicológica de personas que hayan sido diagnosticadas con COVID-19. Limitaciones con relación al muestreo deben ser consideradas en el entendimiento de los resultados.
'Chicha' (Corn Beer) Consumption and Production in the Quebrada de Humahuaca, Jujuy, Argentina in Pre-Inka Times (1250–1450 AD)
Authors: Leibowicz Iván
Published: February 2025

This research explores the production of chicha (corn beer) in the Andes of northwestern Argentina through various interdisciplinary approaches, including materiality analysis, ethnographic work, and comparison with other Andean contexts. The site of Juella, comprising 420 enclosures spread over 6 ha2 in the Quebrada de Humahuaca, Jujuy, is the focal point of this study. Occupations at Juella are limited to the Late Intermediate Period (1250–1450 AD).
During this period, new societies emerged from the aggregation of smaller, dispersed communities into new spaces. Chicha held significant cultural and social importance in these emerging societies, contributing to ethnic identities, annual celebrations, and various rites and rituals among Andean cultures. Beyond its role in cultural practices, chicha played a crucial role in fostering social and cultural cohesion within and among communities. In this case, rather than accentuating social differences, chicha facilitated shared life experiences and the formation of communal identity.
Zmierzch (pewniej) filozofii. W odpowiedzi na książkę „Zmierzch filozofii” Jana Hartmana
Authors: Petryszak Karol
Published: February 2025

Celem artykułu jest dyskusja z wybranymi tezami z książki Jana Hartmana „Zmierzch filozofii” oraz wskazanie wybranych, istotnych błędów, jakie ta publikacja zawiera. Są to: niejasne definiowanie kluczowych terminów, brak danych mogących potwierdzać nieraz fantastyczne tezy Hartmana, niewystarczająca znajomość tradycji filozoficznej, którą Hartman krytykuje. Dyskutuję również z prezentowanym przez Hartmana miejscem filozofa i filozofii w społeczeństwie. Następnie przedstawiam alternatywne rozwiązania zauważonych przez Hartmana problemów, z jakimi boryka się dzisiejsza filozofia. Ogólną konkluzją tekstu jest, że faktycznie następuje zmierzch filozofii, ale nie całej, a jedynie tej, którą prezentuje Hartman.
Building Your Storage Career: Skills for the Future
Authors:   Tech Arch Associate Manager, Accenture Services PVT Ltd, Bangalore, India, T D Mohan Babu
Published: February 2025

The rapid evolution of the storage industry, driven by advancements in technology and increasing data
demands, necessitates a strategic approach to career development in this field. This research article explores the
essential skills required for professionals aiming to build a successful career in storage management and related
domains. Through a comprehensive analysis of current industry trends, skill gaps, and future projections, the study
identifies key competencies that will be pivotal for future success. The methodology involves a systematic review of
existing literature, data collection through surveys and interviews with industry experts, and the application of data
preprocessing and machine learning techniques to analyze the findings. The results highlight the growing importance of
technical skills such as cloud storage management, data security, and automation, alongside soft skills like problemsolving and adaptability. The discussion delves into the advantages of acquiring these skills, the limitations of current
training programs, and the challenges professionals may face in adapting to the evolving landscape. Conclusively, the
paper offers strategic recommendations for individuals and educational institutions to align their training programs with
industry needs, ensuring a robust and future-ready storage workforce.
PCB Defect Detection using Deep Learning and Synthetic Data Generation with ControlNet
Authors:   Associate Professor, Department of CST, School of Computer Science, School of Cyber Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China, Wen Xuezhi , Hossain Zamadder Md Iqbal ,   MSC Student, Department of CST, School of Computer Science, School of Cyber Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China, Doha Dounia ,   MSC Student, Department of CST, School of Computer Science, School of Cyber Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China, Maambo Lubinda ,   MSC Student, Department of CST, School of Computer Science, School of Cyber Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China, Badr Elguerch ,   MSC Student, Department of AI, School of Artificial Intelligence, School of Future Technology, Nanjing University of Information Science and Technology, Nanjing, China
Published: February 2025

This defect detection in printed circuit boards (PCBs) is crucial to ensure reliability and functionality of
the equipment used in all Industries. Based on the analysis, this paper develops a new PCB defect detector composed of
Swin Transformer and synthetic data generation based on ControlNet. Lack of availability of data and expensive
labeling process makes the traditional method of defect identification unproductive. To overcome these challenges, this
study uses ControlNet to create relevant synthetic defect samples that enrich the dataset and enhance generalization.
Experimental findings show high increase in performance from 87.5% to 93.4% in accuracy; 85.2% to 91.8% in
precision and 83.6% to 91.2% in F1-score by integrating synthetic data. The proposed approach had better performance
than baseline models, including CNN and YOLOv5, especially in detecting complex and rare defects. The findings of
this research also serve the purpose of enhancing the reliability and efficiency of PCB inspection to reveal the
effectiveness of using more sophisticated methods of data augmentation and transformer-based models in industrial
problems.
Person Re-identification using Unsupervised Learning and ResNets in Surveillance Systems: A Progressive Clustering-based Learning Approach
Authors:   Associate Professor, Department of CST, School of Computer Science, School of Cyber Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China, Wen Xuezhi , Lubinda Maambo ,   MSC Student, Department of CST, School of Computer Science, School of Cyber Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China, Hossain Zamadder Md Iqbal ,   MSC Student, Department of CST, School of Computer Science, School of Cyber Science and Engineering, Nanjing University of Information Science and Technology, Nanjing, China, Abdirahman Arafat Daud ,   MSC Student, Department of AI, Anhui University of Science and Technology, Huainan, China
Published: February 2025

Unsupervised re-identification of individuals is centered around the extraction of unique features
without labeled data, which holds significant importance for implementations in surveillance. In the present study, we
introduce Progressive Clustering-Based Learning (PCBL), an advanced framework derived from Progressive
Unsupervised Learning (PUL) that enhances clustering and feature acquisition through a confidence-oriented sample
selection methodology. Leveraging the architecture of ResNet-50, PCBL employs deep residual learning to facilitate
robust feature extraction. In contrast to conventional approaches, PCBL identifies dependable samples predicated on
model confidence, thereby mitigating noise and augmenting feature learning. The framework engages in an iterative
process encompassing clustering, sample selection, and fine-tuning to optimize performance. Empirical evaluations
conducted on three extensive re-ID datasets reveal that PCBL surpasses existing methodologies, attaining state-of-theart performance metrics. Specifically, it realizes an enhancement in rank-1 accuracy of +5.6% and an increase in mAP
of +4.2% on the Market-1501 dataset when compared to the original PUL framework. These findings underscore the
efficacy of confidence-based selection in the amplification of feature learning pertinent to real-world surveillance
systems.
Agentic AI: A Paradigm for Autonomous Decision-Making
Authors:   Associate Partner, Enterprise Technology, Data & AI at BAIN & COMPANY, EMEA – Dubai, Jumeirah, Dubai, Panda Meethun
Published: February 2025

In this paper, we explore the paradigm of Agentic AI, where generative AI systems are not limited to
generate responses but become the agent in autonomous and context aware decisions. It discusses defining
characteristics, architectural components, and the ethical considerations; real world applications included in
autonomous vehicles, collaborative robots and personalized services. Challenges such as scalability and interpretability,
as well as future opportunities such as interdisciplinary research and general-purpose adaptability, are also identified in the paper. In emerging arche of Agentic AI, dynamic decision making is addressed by methodological needs in industries.
Navigating the World of Cloud Storage: AWS, Azure, and More
Authors:   Tech & Apps Mgmt Spec. III, Automatic Data Processing, Inc. NJ, USA, Durvasulu Mohan Babu Talluri
Published: February 2025

The rapid evolution of cloud computing has revolutionized data storage solutions, offering scalable,
flexible, and cost-effective alternatives to traditional on-premises systems. This research provides an in-depth analysis of leading cloud storage providers, including Amazon Web Services (AWS), Microsoft Azure, Google Cloud Platform (GCP), and others. By evaluating their system architectures, core components, integration capabilities, and security measures, this study aims to guide organizations in selecting the most suitable cloud storage solutions tailored to their specific needs. The methodology encompasses a comprehensive review of existing literature, comparative analysis of key features, and performance assessments based on data collection and preprocessing. Additionally, the study explores the implementation workflows, including initial setup, automated response generation, real-time transaction verification, and continuous monitoring. Security and compliance are critically examined to ensure data integrity and adherence to regulatory standards. The results highlight the strengths and weaknesses of each provider, offering insights into their scalability, reliability, and cost-efficiency. The discussion addresses the advantages, limitations, and challenges associated with cloud storage adoption, providing a balanced perspective for decision-makers. This research contributes to the field by presenting a structured framework for evaluating cloud storage options, ultimately facilitating informed decisions that enhance organizational data management strategies in the digital era.
Antibiotic resistance is a Russia’s most important challenge: scientific and practical aspects, solutions
Authors: Starodubov Vladimir I. , Beregovykh Valery V. , Akimkin Vasily G. , Kozlov Roman S. , Tutelyan Alexey V. , Ugleva Svetlana V. , Stephani Stefania , Rex John , Karaulov Alexander V. , Sidorenko Sergey V. , Basetti Matteo , Priputnevich Tatyana V. , Stoma Igor O. , Svidzinsky Alexander V. , Eckmann Christian , Tyumentsev Alexander I. , Tyumentseva Marina A. , Prelovskaya Anna N.
Published: February 2025

The problem of antimicrobial resistance (AMR) has become particularly relevant in countries with developed healthcare systems and intensive agriculture over the past 20 years. According to the UN General Assembly on September 22, 2022, antimicrobial resistance (AMR) is already a global problem, causing almost 5 million deaths per year, and by 2050 the annual number of additional deaths worldwide could increase to 10 million persons per year. Currently, to counter the spread of AMR in the world, a partnership of 4 world organizations (WHO, OIE, FAO and UNEP) has been created, leaving the basis for the global concept of “One Health”, which is an integrated, unifying approach aimed at Sustainably balancing and optimizing the health of people, animals and ecosystems. In order to protect the population, the Government of the Russian Federation adopted the “Strategy for preventing the spread of antimicrobial resistance in the Russian Federation for the period until 2030”. The COVID-19 pandemic has impacted the spread of infections caused by multidrug-resistant bacteria worldwide. On the one hand, restrictions and preventive measures introduced in connection with the COVID-19 pandemic, such as reduced travel, distancing, hand hygiene, and environmental treatment, help reduce the spread of infections; on the other hand, the use of antibiotics in patients with COVID-19 is not always justified has exacerbated the public health threat posed by AMR, and as the pandemic progresses throughout the world, the importance of resistance has increased significantly. The resistance of microorganisms to antimicrobial drugs requires improving measures to prevent and limit the spread and circulation of pathogens with antimicrobial resistance, ensuring systemic monitoring of the spread of antimicrobial resistance, and studying the mechanisms of the emergence of antimicrobial resistance.
Analysis of global practices in CAR-T cell production organization and an example of implementation at the Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology, and Immunology
Authors: Badrin Evgeny A. , Maschan Michael A. , Pershin Dmitry E. , Pyatigorskaya Natalia V.
Published: February 2025

In oncology, there is a significant gap in access to advanced treatment methods, such as CAR-T therapy. Despite its high efficacy in treating refractory forms of cancer, CAR-T therapy often faces challenges due to high production costs and complex regulatory conditions. This article analyzes the global experience in CAR-T cell production and regulation, the experience of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, and the prospects for CAR-T therapy development in Russia. The study identifies key factors for the successful implementation of this technology and develops recommendations for enhancing the regulatory framework and infrastructure. Special attention is given to organizing decentralized CAR-T cell production in medical centers, which we believe ensures quicker access to therapy and the development of local expertise. The study emphasizes the importance of refining the regulatory framework and continuing efforts to improve regulatory conditions and workforce training. The prospects for CAR-T therapy development in Russia are associated with expanding access to this innovative method, which can significantly improve patients’ quality of life and enhance the effectiveness of cancer treatment.