bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis
Authors: Jamialahmadi Hamid , Khalili-Tanha Ghazaleh , Rezaei-Tavirani Mostafa , Nazari Elham
Published: September 2024

Context: Metabolic disorders are a growing global concern, especially in developed countries, due to their increasing prevalence. Serum lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), are commonly used clinical biomarkers for monitoring the progression of these metabolic abnormalities. In recent decades, hydrogen-rich water (HRW) has gained attention as a safe and effective treatment, with regulatory effects on lipid peroxidation and inflammatory responses in clinical trials. Objectives: This systematic review and meta-analysis aim to evaluate the effectiveness of HRW therapy on blood lipid profiles in randomized controlled trials (RCTs) for metabolic disorders. Methods: Following the PRISMA guidelines, a search for RCT studies was conducted in the PubMed, Web of Science, Embase, and Google Scholar databases up to January 2024. Eight studies that met all eligibility criteria, including RCTs involving metabolic dysfunctions and evaluations of lipid profiles, were included for further analysis. Data extraction was followed by quality evaluation using the Jadad scoring system. Meta-analysis was conducted using STATA software. Results: The eight selected RCTs included a total of 357 patients with various metabolic disorders. All studies showed either no or low risk of bias. The overall levels of TG [95% CI: -0.27 (-0.47, -0.07)], TC [95% CI: -0.07 (-0.32, -0.18)], and LDL [95% CI: -0.06 (-0.28, 0.15)] demonstrated slight decreases across the studies. However, there was some heterogeneity in HDL levels [95% CI: -0.11 (-0.37, 0.14)] among the studies (I² = 37.32%). Meta-regression analysis further indicated a positive association between the outcomes and the duration of the intervention as a moderating factor. Conclusions: Hydrogen-rich water demonstrated modest lipid-lowering effects in patients with metabolic disorders. However, due to the observed heterogeneity in HDL variations, further long-term trials involving larger populations are needed to clarify these inconsistencies.
Explication of the concept of ambivalence in the trajectory of a modern woman's life path
Authors: Сергеева С.В.
Published: September 2024

в современную действительность, когда окружающая реальность подчинена законам глобализации и динамичного развития инноваций, технологий и информатизации, траектория жизни индивида претерпевает существенные коллизии, что также сказывается на становлении современной женщины как личности на протяжении всего ее жизненного пути. При этом субъекты, находящиеся в середине континуальной шкалы – амбиверты – добиваются лучших показателей во многих видах деятельности. Феномен амбивертности был дифференцирован К. Юнгом, тем не менее, научные изыскания, в которых детально начала рассматриваться «феминная амбиверсия» и ее специфика, только появляются в научном сообществе, что предопределяет новизну данного исследования. Гипотетически, амбивертность свойственна основной массе населения, однако, может видоизменяться под воздействием внешних и внутренних причин и катализаторов. Женщины-амбиверты способны предоставлять бόльшее количество моделей поведения, релевантных для различных жизненных ситуаций и рабочей среды – это детерминирует целесообразность их включения в значимые для социума события и роли. Амбиверты, в свою очередь, извлекают выгоду из этого за счет способности расширять свою эрудицию и получать опыт, вследствие чего они не просто эффективно расставляют приоритеты в своих внутренних и внешних ресурсах, но и достигают существенных высот на протяжении жизни.

in modern reality, when the surrounding reality is subject to the laws of globalization and the dynamic development of innovations, technologies and informatization, the trajectory of an individual's life undergoes significant collisions, which also affects the formation of a modern woman as a person throughout her life. At the same time, subjects in the middle of the continuum scale – ambiverts – achieve the best performance in many types of activities. The phenomenon of ambivalence was differentiated by K. Jung, however, scientific research, in which the "feminine ambiversion" and its specifics began to be considered in detail, only appear in the scientific community, which determines the novelty of this study. Hypothetically, ambivalence is characteristic of the majority of the population, however, it can change under the influence of external and internal causes and catalysts. Ambivert women are able to provide a greater number of behaviors relevant to various life situations and work environments - this determines the expediency of their inclusion in socially significant events and roles. Ambiverts, in turn, benefit from this through the ability to expand their erudition and gain experience, as a result of which they not only effectively prioritize their internal and external resources, but also achieve significant heights throughout their lives.
Development of key skills as the main factor in the establishment of a competency-based approach in education
Authors: Петрова Т.Э.
Published: September 2024

в данной статье анализируются исторические этапы развития компетентностного подхода в образовательной сфере как в России, так и за рубежом. Освещаются мнения различных авторов относительно терминологической определённости понятий "компетенция" и "компетентность". Особая роль отведена причинам, предшествующим переходу от долго существовавшей оценке образовательного результата с позиции знаний, умений и навыков к интегральному личностному и социальному показателю через оценку компетенций. Показана роль ключевых навыков в комплексной оценке компетенций как факторов, обеспечивающих успешную адаптацию к изменениям и умению применять освоенные компетенции в различных видах деятельности.

this article analyzes the historical stages of the development of the competency-based approach in education in both Russia and abroad. It highlights the views of various authors regarding the terminological precision of the concepts "competence" and "competency". A special role is given to the reasons preceding the transition from the long-existing assessment of educational results from the standpoint of knowledge, skills and abilities to an integral personal and social indicator through the evaluation of competencies. The role of key skills in the comprehensive assessment of competencies as factors ensuring successful adaptation to changes and the ability to apply acquired competencies in various activities is shown.
The role of ligand-associated activation of vitamin D receptors in lung remodeling against the background of bleomycin-induced damage
Authors: Брауде И.Е. , Галышевская А.А. , Энзель Д.А.
Published: September 2024

ремоделирование легочной ткани, вызванное блеомицин-индуцированным повреждением, представляет собой сложный процесс, исследование которого имеет важное значение для понимания механизмов развития фиброза и разработки эффективных терапевтических стратегий. В последние годы возрастающий интерес ученых направлен на изучение роли витамина D и его рецепторов в этих процессах. Витамин D, традиционно ассоциируемый с кальциевым гомеостазом и здоровьем костей, демонстрирует также значительные противовоспалительные и иммуномодулирующие свойства. Активация рецепторов витамина D лигандами регулирует экспрессию множества генов, участвующих в воспалительных и фибротических процессах. Наша работа фокусируется на выяснении того, каким образом лиганд-ассоциированная активация рецепторов витамина D влияет на ремоделирование легких при блеомицин-индуцированном повреждении. По данным литературного обзора, проведённые исследования показали, что активация рецепторов витамина D может существенно замедлить прогрессирование воспалительных реакций и уменьшить выраженность фибротических изменений. Полученные данные свидетельствуют о том, что витамин D может стать перспективным агентом для разработки новых методов лечения и профилактики легочных заболеваний, связанных с хроническим повреждением и фиброзом. Однако, необходимо дальнейшее доследование молекулярных механизмов этого влияния, а также проведение клинических испытаний, чтобы подтвердить эффективность и безопасность применения витамина D в данных клинических контекстах.

the remodeling of lung tissue caused by bleomycin-induced damage is a complex process, the study of which is important for understanding the mechanisms of fibrosis development and developing effective therapeutic strategies. In recent years, scientists have been increasingly interested in studying the role of vitamin D and its receptors in these processes. Vitamin D, traditionally associated with calcium homeostasis and bone health, also demonstrates significant anti-inflammatory and immunomodulatory properties. Activation of vitamin D receptors by ligands regulates the expression of many genes involved in inflammatory and fibrotic processes. Our work focuses on elucidating how ligand-associated activation of vitamin D receptors affects lung remodeling in bleomycin-induced damage. According to the literature review, studies have shown that activation of vitamin D receptors can significantly slow down the progression of inflammatory reactions and reduce the severity of fibrotic changes. The data obtained indicate that vitamin D may become a promising agent for the development of new methods of treatment and prevention of lung diseases associated with chronic damage and fibrosis. However, further investigation of the molecular mechanisms of this effect is necessary, as well as clinical trials to confirm the efficacy and safety of vitamin D in these clinical contexts.
Life-meaning orientations as part of the spiritual and moral sphere of youth
Authors: Никулина А.А.
Published: September 2024

в современном мире вопрос формирования смысложизненных ориентаций личности становится все более актуальным и значимым. Смысложизненные ориентации играют важную роль в формировании духовно-нравственной сферы личности. Они определяют основные ценности, цели, стремления и убеждения человека, а также его отношение к жизни и окружающему миру. Исследование этой темы актуально, так как анализ смысложизненных ориентаций в эпоху вызовов позволяет понять, как человек строит свою жизнь в условиях нестабильности и изменений. Понимание смысложизненных ориентаций также позволит разрабатывать программы духовно-нравственного развития личности, а также способствует достижению баланса и гармонии в сложных условиях современного мира. Данная работа выполнена в рамках выполнения Государственного задания Министерства просвещения Российской Федерации (№1024032700410-6-5.1.1-5.1.1-5.1.1.) по теме «Психологические детерминанты формирования духовно-нравственных ценностей современной семьи» (2024 г.).

in the modern world, the issue of the formation of meaningful life orientations of a person is becoming more relevant and significant. Life-meaning orientations play an important role in the formation of the spiritual and moral sphere of a person. They define the basic values, goals, aspirations and beliefs of a person, as well as his attitude to life and the world around him. The study of this topic is relevant, since the analysis of life orientations in the age of challenges allows us to understand how a person builds his life in conditions of instability and change. Understanding life orientations will also make it possible to develop programs for the spiritual and moral development of a person, as well as contribute to achieving balance and harmony in the difficult conditions of the modern world. This work was carried out within the framework of the State assignment of the Ministry of Education of the Russian Federation (№1024032700410-6-5.1.1-5.1.1-5.1.1.) on the topic "Psychological determinants of the formation of spiritual and moral values of the modern family" (2024).
Historical analysis of the semantic component of professional creative thinking
Authors: Козьяков Р.В.
Published: September 2024

в статье обосновывается актуальность исследования смыслового компонента профессионального креативного мышления. Представлен исторический анализ смыслового компонента в трудах зарубежных и отечественных исследователей: Гераклита, Пифагора, Аристотеля, К. Ясперса, Ф. Аквинского, Л. Фейербенда, Р. Декарта, И. Канта, В. Вундта, У. Джеймса, М. Вебера, О. Кюльпе, А.Р. Лурии, Л.С. Выготского, Д.А. Леонтьева, К. Дункера, М. Вертгеймера, М. А. Холодной, Б. Брунера, А. Адлера, З. Фрейда, М.Ш. Магомед-Эминова, Э. Вейкоп-Джонсона, В. Франкла, Дж. Келли, А.Н. Леонтьева, Л. Томаса, Е.А. Артемьевой, В. Ф. Петренко, А.Г. Шмелева, К. Роджерса, С.Л. Рубинштейна, Ф.В. Бассина, К.А. Абульхановой-Славской, О.К. Тихомирова. В заключении представлены выводы полученные в ходе исследования и представлено собственное понимание автором, а также представлены перспективы организации дальнейших исследований.

the article substantiates the relevance of the study of the semantic component of professional creative thinking. The historical analysis of the semantic component in the works of foreign and domestic researchers is presented: Heraclitus, Pythagoras, Aristotle, K. Jaspers, F. Aquinas, L. Feuerbend, R. Descartes, I. Kant, V. Wundt, W. James, M. Weber, O. Kulpe, A. R. Luria, L.S. Vygotsky, D.A. Leontiev, K. Dunker, M. Wertheimer, M. A. Kholodnaya, B. Bruner, A. Adler, Z. Freud, M.S. Magomed-Eminov, E. Wakop-Johnson, V. Frankl, J. Kelly, A.N. Leontiev, L. Thomas, E.A. Artemyeva, V.F. Petrenko, A.G. Shmelev, K. Rogers, S.L. Rubinstein, F.V. Bassin, K.A. Abulkhanova-Slavskaya, O.K. Tikhomirov. In conclusion, the conclusions obtained during the research are presented and the author's own understanding is presented, as well as the prospects for organizing further research.
Identification of development risk factors and identification of "risk groups" among middle-level rural school students
Authors: Джембек Ю.И. , Моторина П.А. , Ефремова А.В. , Аникин А.Н. , Мосинцев Д.Д. , Виталёва Я.В.
Published: September 2024

социопсихологическая среда развития сельских школьников имеет свои отличительные особенности. Данная статья посвящена изучению этих особенностей и их влияния на развитие подростков, а также выявлению среди обучающихся среднего звена детей «группы риска». Авторы статьи проанализировали труды психологов по вопросу детей «группы риска», выявили возрастные особенности учащихся средних классов, изучили специфику социально-психологической среды сельской школы. С учетом полученной информации, авторы провели исследование факторов риска, которые могут оказывать на школьников влияние и являются предпосылками для развития различных форм девиантного поведения у учащихся средних классов сельских школ. В результате исследования авторы пришли к выводу, что большинство опрошенных школьников подвержены социальной дезадаптации в результате воздействия негативных факторов на процесс социализации. Также мы выявили признаки агрессивности, проблемы во взаимоотношениях с семьей, наличие акцентуаций характера.

the socio-psychological development environment of a student from the village has its own distinctive features. This article is devoted to the study of these features and their impact on the development of secondary school students, as well as the identification of children of "risk groups" among them. The authors of the article analyzed the work of psychologists on the problem of children of the "risk group" and the age characteristics of middle-level students, and also conducted a study of personal factors and social environment factors that may be prerequisites for the development of various forms of deviant behavior among middle-level students of rural schools. After analyzing the results of the study, we came to the conclusion that the majority of the surveyed schoolchildren are subject to social maladaptation as a result of the impact of negative factors on the process of socialization. We also identified signs of aggression, problems in relationships with family, and the presence of character accentuations.
Definition of the concept of problematic trance in the light of psychological theories and doctrines
Authors: Волкова К.В.
Published: September 2024

в данной статье исследуется понятие проблемного транса в контексте различных психологических теорий и доктрин. Проведен анализ терминов «проблема» и «транс», рассмотрены их основные значения в таких науках как философия, социология и психология. Для понимания состояния проблемного транса требуется интеграция знаний из разных областей науки, что делает это направление актуальным для дальнейших научных изысканий и практического применения. Особое внимание уделено дифференциации проблемного транса от схожих состояний, таких как фрустрация и замирание, а также от тревожных и депрессивных состояний человека. Выделены ключевые характеристики и признаки проблемного транса. Проблемный транс рассматривается как состояние, характеризующееся шаблонностью мышления, трудностями в коммуникации и отсутствием контроля над эмоциями, что может приводить к значительному ухудшению психофизиологического состояния. В статье рассматриваются ключевые особенности проблемного транса, такие как его временные рамки, склонность к когнитивным искажениям и социальные последствия, включая отчуждение и изоляцию. В статье подчеркивается важность междисциплинарного подхода к изучению этого состояния и необходимость разработки эффективных стратегий психологической помощи, направленной на преодоление проблемного транса и предотвращение долговременных негативных последствий для личности и общества в целом.

this article explores the concept of problematic trance in the context of various psychological theories and doctrines. The analysis of the terms “problem” and “trans” is carried out, their main meanings in such sciences as philosophy, sociology and psychology are considered. Understanding the state of problematic trance requires the integration of knowledge from different fields of science, which makes this area relevant for further scientific research and practical application. Special attention is paid to the differentiation of problematic trance from similar conditions, such as frustration and fading, as well as from anxiety and depressive states of a person. The key characteristics and signs of problematic trance are highlighted. Problematic trance is considered as a condition characterized by a pattern of thinking, difficulties in communication and lack of control over emotions, which can lead to a significant deterioration in the psychophysiological state. The article examines the key features of problematic trance, such as its time frame, tendency to cognitive distortions and social consequences, including alienation and isolation. The article emphasizes the importance of an interdisciplinary approach to the study of this condition and the need to develop effective strategies for psychological assistance aimed at overcoming problematic trance and preventing long-term negative consequences for the individual and society as a whole.
Disorders of the hemostasis system in the pathogenesis of exacerbation of chronic generalized periodontitis after a coronavirus infection
Authors: Тамбовцев С.А. , Федоськина А.С. , КомароваА Е. , Абрашина И.В. , Громова Е.В. , Власова Т.И.
Published: September 2024

в статье представлены результаты изучения системы гемостаза среди пациентов, которые испытали на себе воздействие коронавирусной инфекции COVID-19 и одновременно страдают хроническим генерализованным пародонтитом. Рассмотрены основные аспекты функционирования гемостаза, включая эндотелиальную активность, тромбоцитарные показатели и плазменные значения этой системы. Установлено, увеличение содержания фактора Виллебранда, уровня фибриногена, количества тромбоцитов относительно контроля, при этом указанные показатели не выходили за пределы референсных значений. Проведение комплексной терапии ХГП показало свою эффективность в купировании клинических признаков воспаления, при этом показатели системы гемостаза при тенденции к приближению к контрольным данным оставались достоверно отличными от последних.

this article presents the results of a study of the hemostasis system hemostasis among patients who have experienced COVID-19 coronavirus infection and concurrently suffer from chronic generalized periodontitis. The main aspects of hemostasis functioning, including endothelial activity, platelet indices, and plasma values of this system are considered. The research established increase of the content of von Willebrand factor, fibrinogen level and platelet count relative to the control, while these indicators was within the reference values. The complex therapy for CGP showed its effectiveness in relieving clinical signs of inflammation, while the indicators of the hemostatic system remained significantly different from control.
The conjugacy of coordinate representations and the ability to recognize complexly organized somatosensory stimuli
Authors: Авдеева Е.С. , Сайфутдинов М.С.
Published: September 2024

система «схемы тела» ответственна за интеграцию разнородной сенсорной информации в процессе формирования моторного навыка. Это имеет большое значение для растущего детского организма. Цель работы: оценка вклада различных модальностей сложно организованной соматосенсорной чувствительности в формирование «системой схемы тела» координатных представлений у детей с нарушениями речи и слуха. Исследование проведено на 34 детях 5-11 лет, 17 мальчиков, 17 девочек: с нарушениями слуха (10 человек), нарушения речи (12 человек) в сравнении с контрольными испытуемыми (10 человек). Использовали тесты на координатные представления, на локализацию тактильного стимула и на проприоцепцию. Оценивали долю правильных выполнений теста в процентах. Удалось выявить среднюю степень сопряжения между способностью локализовать сложно-организованный поверхностный стимул и уровнем координатных представлений у детей с нарушениями речи. Для сложной проприоцетивной чувствительности такое сопряжение не проявляется в явном виде для всех трёх групп сравнения. Таким образом, у детей на фоне нарушений речи отмечен средний уровень сопряжения между способностью локализовать сложно организованный сенсорный стимул и координатными представлениями.

the "body schema" system is responsible for the integration of heterogeneous sensory information in the process of motor skill formation. This is of great importance for the growing child's body. The purpose of the work is to assess the contribution of various modalities of complexly organized somatosensory sensitivity to the formation of coordinate representations by the "body schema system" in children with speech and hearing impairments. The study was conducted on 34 children aged 5-11 years, 17 boys, 17 girls: hearing impaired (10 people), speech disorders (12 people) in comparison with control subjects (10 people). Tests were used for coordinate representations, for localization of a tactile stimulus, and for proprioception. The percentage of correct test completion was estimated. It was possible to identify an average degree of coupling between the ability to localize a complexly organized surface stimulus and the level of coordinate representations in children with speech disorders. For complex proprioceptive sensitivity, such a coupling does not manifest itself explicitly for all three comparison groups. Thus, children with speech disorders have an average level of conjugation between the ability to localize a complexly organized sensory stimulus and coordinate representations.
Laboratory analysis of risk factors for arteriovenous access thromboembolism in patients with end-stage renal failure secondary to diabetic nephropathy
Authors: Синельник С.В.
Published: September 2024

некоторые из пациентов гемодиализа сталкиваются с нежелательными осложнениями артериовенозного доступа – с тромбозами. Это острое состояние требует незамедлительной коррекции, необходимости повторного оперативного вмешательства, и, как следствие, приводит к снижению качества и продолжительности жизни. Так почему же часть пациентов живут длительное время, без каких либо осложнений, а у других, буквально на следующий день, возникает тромбоз артериовенозной фистулы. Было ли это неблагоприятно стечение обстоятельств, которых нельзя избежать, либо же есть факторы риска, зная которые можно предупредить данное осложнение. Для того чтобы разобраться в поставленных вопросах, и выявить факторы, которые приводят к данному осложнению, были проанализированы лабораторные данные двух категорий пациентов. Пациенты, которые ни разу не сталкивались с осложнениями артериовенозного доступа, и другая группа – пациенты, у которых в анамнезе прослеживается один, два, три и более тромбозов артериовенозной фистулы в анамнезе. На основе полученных данных, сделаны выводы, которые помогут практикующим врачам снизить количество повторных операций по поводу формирования артериовенозных доступов у одного пациента, что приведет к увеличению качества и продолжительности жизни данной категории больных.

some hemodialysis patients experience undesirable complications of arteriovenous access – thrombosis. This acute condition requires immediate correction, the need for repeated surgery, and, as a result, leads to a decrease in the quality and duration of life. So why do some patients live for a long time, without any complications, while others, literally the next day, experience thrombosis of an arteriovenous fistula? Was it an unfavorable combination of circumstances that cannot be avoided, or are there risk factors, knowing which this complication can be prevented? To shed light on the causes of complications during arteriovenous access creation, researchers analyzed laboratory data from two patient groups: those who never experienced complications and those with a history of one, two, three, or more arteriovenous fistula thromboses. The findings provide insights that will help doctors minimize the need for repeated surgeries to establish arteriovenous access in a single patient, ultimately improving the quality and longevity of life for this patient group.
Evaluando el desarrollo de Internet en Argentina: Utilizando los indicadores ROAM-X de Universalidad de Internet de la UNESCO
Authors: Caeiro Carolina , Ferracutti Delfina , Fernanda Martinez Maria , Kirschbaum Ivan , Ortiz Juan
Published: September 2024

El Centro de Estudios en Tecnología y Sociedad (CETyS) de la Universidad de San Andrés realizó una evaluación detallada del desarrollo de Internet en Argentina, utilizando los indicadores de universalidad ROAM-X de la UNESCO. Este análisis, realizado entre agosto de 2021 y marzo de 2022, ofrece una evaluación exhaustiva sobre el entorno digital del país, destacando tanto los logros significativos como los desafíos pendientes. El estudio utilizó 109 indicadores principales y 21 contextuales para valorar cómo Internet en Argentina protege los derechos humanos, promueve la apertura, garantiza la accesibilidad para todos y fomenta la colaboración entre múltiples partes interesadas. El enfoque inclusivo involucró a diversas partes interesadas en la recolección de datos, identificando áreas para mejorar el panorama digital argentino. El informe resalta la necesidad urgente de asegurar el acceso universal a Internet y proteger los derechos digitales como elementos esenciales para el crecimiento continuo del país. También subraya la importancia de defender los derechos humanos en línea y contrarrestar la desinformación y el discurso de odio. Este informe no solo proporciona un diagnóstico detallado del desarrollo de Internet en Argentina, sino que también guía a los formuladores de políticas públicas y actores del sector privado y la sociedad civil hacia la promoción de una sociedad digital equitativa y segura.
Improving the Digital Skills of Young Voters Through Education to Prevent Election Hoaxes Using the Kalimasada Mafindo Application
Authors: Gushevinalti Gushevinalti , Sakinah Nazwa Iqrami , Ridiansyah Oka
Published: September 2024

The practical training on fact-checking using Kalimasada Mafindo was conducted to improve digital literacy and participants' ability to counteract the spread of hoaxes about elections. This training was held on 2 July 2024 at the Village Hall Hall, attended by young voters and village officials in Panca Mukti Village who were enthusiastic about understanding the importance of information verification in the digital era. The resource person or facilitator of this activity is Mafindo Volunteers, who are certified in the Fact Check. The training material includes an introduction to Kalimasada as one of the tools in the fact-checking process, techniques for identifying false information, and steps to verify data through credible sources. The participants showed positive and interactive responses during a practice session with the Kalimasada chatbot with the WhatApps 085921600500 number, where they successfully used Kalimasada to verify the correctness of information quickly and accurately. The final evaluation showed that participants understood the concept of fact-checking and had adequate ability to apply it in daily life to combat disinformation, significantly ahead of the 2024 Pilkada.
The Influence of Price Perception, Service Quality, Store Atmosphere and Word of Mouth on Purchasing Decisions
Authors: Kevin Ainul , Simon Zainal Zawir
Published: September 2024

This research was conducted with the aim of examining the influence of price perceptions, service quality, store atmosphere, and word of mouth on purchasing decisions. The sample used in this research was consumers of the Kopi Kecil coffee shop in Cempaka Putih who had made a purchase and dine-in at least once at the Kopi Kecil coffee shop, totaling 100 people. The data collection method uses a questionnaire. Data analysis uses multiple linear regression analysis. The study results show that partially, price perception has an insignificant influence on purchasing decisions, service quality has an insignificant influence on purchasing decisions, partially, store atmosphere has a positive and significant influence on purchasing decisions, and partially, word of mouth has a positive influence and is significant to purchasing decisions. Managerial implications in this research Managers must understand how price influences customer perceptions, offer product packages at cheaper prices than buying them separately to increase the value perceived by customers, and Collect and analyze feedback from customers to find out areas that need to be improved in service.
A Framework to Connect Viral Quasispecies, Microbiome, and Host
Authors: Nehri Leman Nur , Koçoğlu Seher Elif
Published: September 2024

Aim: The aim of this study is to investigate the potential interactions between SARS-CoV-2 Spike protein variants and the host microbiota. While the Spike protein is known for its role in mediating viral entry into host cells, its impact on the host’s microbial communities remains unclear. Given the microbiota’s critical role in modulating immune responses and maintaining host homeostasis, understanding these interactions could provide new insights into disease progression and immune evasion mechanisms associated with COVID-19. By leveraging parameters extracted from the current literature and analyzing publicly available datasets, we seek to elucidate how these interactions might influence the severity of COVID-19 and the pathogenesis of emerging viral variants. This research may also highlight potential therapeutic targets for mitigating the effects of SARS-CoV-2 and its evolving forms.
Methods: This study investigates the interaction between Spike protein variants of SARS-CoV-2 and the host microbiota. To this end, the associations between various SARS-CoV-2 variants and different host factors derived from urban ecosystems have been statistically analyzed. Specifically, the influence of these host factors, which are linked to distinct microbiota compositions, on the interaction with Spike protein variants has been evaluated. A Bayesian Network approach has been employed for this analysis to model the complex relationships and dependencies among the host factors and microbiota compositions.
Results: This study investigates the interaction between Spike protein variants of SARS-CoV-2 and host factors. Hypothesis 1 (H1) posits that specific combinations of various host factors can explain the infectivity of SARS-CoV-2. The analyses reveal that 20 SARS-CoV-2 variants and mutants are significantly affected by various parameters (Table 2), indicating that H1 cannot be rejected. Additionally, it is suggested that the connections mentioned in H1 indicate the presence of a carrier within the host, potentially the microbiome. Hypothesis 2 (H2) proposes that the microbiota serves as the primary carrier of host factors, influencing the selection of specific SARS-CoV-2 mutants. To test this hypothesis, a Bayesian Network was constructed (Figure 3), which identified the probabilistic relationships between potential microbiota compositions and Spike variants.
Conclusion: As a result, it is suggested that different Spike protein variants may be present in hosts with varying microbial compositions. Additionally, the microbiota could serve as a carrier that influences the selection of viral mutants in hosts within the population, potentially impacted by external factors such as environmental conditions and human interactions.
Administrative Law in the Era of Digital Technologies: New Opportunities for the Saving of Cultural Heritage and Public Education
Authors: Gulyamov Said , Zolea Sirio , Babaev Jahongir , Akromov Akmal , Ubaydullaeva Anna
Published: September 2024

The rapid development of digital technologies has transformed various aspects of human life, including the save and promotion of cultural heritage. The present article explores the intersection of administrative law and digital technologies in relation to the protection of cultural heritage and public education. The study aims to analyze the role of administrative law in providing a legal framework for the utilization of digital technologies to safeguard cultural heritage, address the challenges arising from the adoption of new technologies, and promote public education on the importance of saving historical values.
The article begins by examining the innovative methods employed in the save of cultural heritage, such as virtual museums, augmented and virtual reality technologies, and artificial intelligence. The role of administrative law in facilitating the integration of these technologies into the save process is emphasized, as it provides the necessary legal support and guidance to ensure their effective and responsible use.
Next, the article delves into the primary challenges and problems faced by the cultural heritage sector in adopting digital technologies. These include issues related to data privacy and security, intellectual property rights, and the need for harmonization between national and international legal frameworks. The article highlights the importance of administrative law in addressing these challenges and ensuring a balanced approach that respects the rights of all stakeholders.
The study then discusses the interaction between technology and law in the context of heritage protection. It analyzes the existing legal frameworks governing the use of digital technologies in the cultural heritage sector and identifies areas for improvement and potential legal developments. The role of administrative law in facilitating international cooperation and collaboration in the save of cultural heritage is also explored.
Finally, the article presents an overview of the prospects for the development of digital cultural heritage management. It outlines the potential benefits of integrating digital technologies into the save process, such as increased accessibility and awareness of cultural heritage, as well as the opportunities for public education and engagement. The article concludes by emphasizing the crucial role of administrative law in ensuring that the digital transformation of the cultural heritage sector is carried out responsibly and sustainably.
LOS BENEFICIOS DEL CANTO EN EL CONTEXTO DE LAS DEMENCIAS
Authors: Mercadal-Brotons Melissa
Published: September 2024

Antecedentes: Los tratamientos farmacológicos para manejar los síntomas de la demencia han mostrado una efectividad limitada por lo que las intervenciones psicosociales suelen ser la primera opción. Investigaciones recientes destacan el canto como una actividad particularmente beneficiosa para las personas con demencia. Objetivo: El objetivo de este artículo es presentar una síntesis narrativa de la literatura existente desde enero de 2019 hasta junio de 2024 sobre las contribuciones del canto en personas con demencia y sus cuidadores familiares. Método: Se realizó una búsqueda en tres bases de datos: PubMed, PsycINFO y ScienceDirect. También se realizaron búsquedas manuales en "Voices: A World Forum for Music Therapy" desde enero de 2019 hasta junio de 2024, así como en ResearchGate. Esta revisión descriptiva incluyó estudios cuantitativos, cualitativos y de métodos mixtos. Resultados: Nueve estudios cumplieron con los criterios de inclusión. La síntesis narrativa identificó cinco áreas principales de impacto: compromiso/participación (musical y social), función cognitiva (incluyendo reminiscencia), depresión y sentimientos o emociones positivas (como parte del bienestar), calidad de vida, y la relación de cuidado y/o la experiencia de cuidado entre la persona con demencia y el cuidador. Conclusiones: Los resultados de esta revisión destacan los posibles beneficios del canto en el bienestar de las personas con demencia y sus cuidadores familiares, así como la importancia de continuar investigando en este campo.
ЖАСАНДЫ ҚҰРАЛ ҚАҚПАН ЖӘНЕ ҚАҚПАНМЕН АҢ АУЛАУ
Authors: Абу Алпамыс
Published: September 2024

Аңдатпа. Түркі халықтары арасында қазақтың материалдық және материалдық емес мұралары қатарында аң аулау, қақпан құру және қақпанмен аң аулауды қарастыру өз алдына болса да, зор маңызға ие. Еліміздің ғасырлар бойы қалыптасқан көшпелі тұрмысында аң аулау мәдениеті жоғары деңгейде болды десек, артық айтқандық болмас. Аң қағудың қалыптасу тарихы тас дәуіріндегі алғашқы қауымдық құрлыстан бастау алады және оның дамуында түрлі кезеңдер болды. Сөзіміздің айғағы үңгір қабырғалары, жартастың күнгей тегістік беттерінде бәдіздей бейнеленген бедерлі суреттер аңшылықты зерттеудегі басты дерек көзі негізінде зерттеушілер назарын аударғаны сөзсіз. Аңшылықтың қалыптасуы мен аңшылық құралдың даму кезеңдері, оның тарихын зерттеушілер түрліше мақсатта қарастырса да, ел жадында сақталған аңшылық саят құру аясында, бүгінде ермекке айналғандай көрінеді. Мақалада автор аңшылықтың ел тарихындағы маңызын қарастырады. Аңшылық тарихын арнайы зерттеген ғалымдар бірнеше кезеңге бөліп қарастырған болса, автор аңшылықпен қатар жасанды құрал негізінде басты назарды қақпанмен аң аулауға аударады.
Мақалада тарихи-мәдени Орталықтың («Атамекен» тарихи-мәдени орталығы) қор жинағының қалыптасуы, зерттеу нысаны ретінде нақты жәдігердің музей қызметінде танымды арттыратын заттай құндылық етіп қарастыру призмасы арқылы еліміздің музейлік қорларындағы аңшылық жасанды құралдың аңшылықтағы әлеуетін, оның дамуы тарихымен байланысты тарихи мән-маңызы нақтыланады. Ұсынылып отырған зерттеу Орталықтың қорына өткізілген «жасанды құрал қақпанды» зерделеу аясында жазылды.
ҚАЗАҚ ЖӘНЕ ТҮРІК ТЕАТР ӨНЕРІ: ҰҚСАСТЫҚ ПЕН ЕРЕКШЕЛІКТЕРІ
Authors: Хасиетова Жания , Исмагамбетова Зухра
Published: September 2024

Аңдатпа.Мақалада ұлттық бірегейлікті әспеттейтін бірден бір мәдени орта театр болғандықтан,Қазақстан мен Түркияның театр өнерін салыстырып,  ұлттық құндылықтар мен ұлттық бірегейлікті бейнелейтін театр символдары мен құралдарын айғақтадық. Сонымен қатар, екі елдің театрлары арасындағы сабақтастық зерттеліп, салыстырмалы талдау жүргізілді. Қазақстан мен Түркияның дәстүрлі театр өнерінің шығу тарихы мен ерекшеліктері талданып, олардың түрлері жанр бойынша бөлініп қарастырылды. Атап айтқанда, «қаракөз», «медда», «орта ойыны», «комедия», «трагедия», «драма», «sound драма» сынды қойылымдардың жанрлық түрлеріне талдау жүргізілді.
Ғылыми мақала қазақ театры мен түрік театр элементтерінің ортақ ерекшеліктерін анықтау, бейімдеу және трансформациялауды мақсат етеді. Зерттеу нәтижелері бойынша, қазақ және түрік театр өнерінің бір-бірімен мәдени және ұлттық сабақтастықтары айқындалып, театр өнері әлеуметтік институт ретінде ұлттық бірегейлікті әспеттейтін орта ретінде сараланды. Сонымен қатар, зерттеу жұмысы екі ел арасындағы мәдениеттер мен театр дәстүрлерінің өзара әрекеттесуін түсінуді кеңейтуге қызығушылық тудырды.
Looking into Concept Explanation Methods for Diabetic Retinopathy Classification
Authors: Storås Andrea M. , Sundgaard Josefine V.
Published: September 2024

Diabetic retinopathy is a common complication of diabetes, and monitoring the progression of retinal abnormalities using fundus imaging is crucial. Because the images must be interpreted by a medical expert, it is infeasible to screen all individuals with diabetes for diabetic retinopathy. Deep learning has shown impressive results for automatic analysis and grading of fundus images. One drawback is, however, the lack of interpretability, which hampers the implementation of such systems in the clinic. Explainable artificial intelligence methods can be applied to explain the deep neural networks. Explanations based on concepts have shown to be intuitive for humans to understand, but have not yet been explored in detail for diabetic retinopathy grading. This work investigates and compares two concept-based explanation techniques for explaining deep neural networks developed for automatic diagnosis of diabetic retinopathy: Quantitative Testing with Concept Activation Vectors and Concept Bottleneck Models. We found that both methods have strengths and weaknesses, and choice of method should take the available data and the end user’s preferences into account. Our code is available at https://github.com/AndreaStoraas/ConceptExplanations_DR_grading
The Role of Precision Medicine in Rare Diseases
Authors:   School of Natural and Applied Sciences Kampala International University Uganda, Mugo Moses H.
Published: September 2024

Precision medicine, driven by advances in next-generation sequencing (NGS) and genomics, is transforming the diagnosis and treatment of rare diseases. Rare diseases, often genetic, present unique challenges due to their low prevalence and the heterogeneity of symptoms. Precision medicine offers a promising solution by channeling therapies to an individual’s genetic profile, providing earlier diagnoses, and guiding treatment decisions. This review discusses the definition and prevalence of rare diseases, explores the challenges in their diagnosis and treatment, and highlights the potential of precision medicine through case studies and emerging technologies. Future directions include overcoming data integration challenges and fostering collaborations in bioinformatics and AI for improved therapeutic outcomes. Keywords: Precision Medicine, Rare Diseases, Next-Generation Sequencing (NGS), Genomics, Personalized Therapy.
Bir Aile Hekimliği Biriminde COVID-19 Tanısı Alanların Özellikleri ve Hastalık Süreçleri
Authors: Albayrak Zühal , Acar Tijen
Published: September 2024

Koronavirüs hastalığı 2019 (COVID-19), bilinmeyenleri olan bir halk sağlığı sorunudur. Burada, COVID-19 hastalarının hastalık sürecine etkili özelliklerini ortaya çıkartarak hastalığı önlemek, hastalık sürecine müdahale olanağı sağlamak, koruyucu önlemlerin farkındalığını artırmak amaçlanmıştır. Bu tanımlayıcı çalışmada, Keçiören’de bir aile hekimliği birimine kayıtlı, COVID-19’la tanılanmış, iletişim kurabilen, erişkin 227 gönüllüye, 54 soruluk veri toplama formu yüz yüze uygulanmıştır. P<0,05’se istatistiksel anlamlı değerlendirilmiştir. Yaşları 18-78 değişen katılımcıların 144’ü (%63,43) kadın olup korunma (maske %88,99, mesafe % 88,54, el yıkama %98,24), sağlıklı yaşam davranışı %62,11, ek ilaç-vitamin %81,06 ve besin desteği %61,67 bulunmuştur. Okuma yazma bilmeyen, sigarayı bırakmış, beden kitle indeksi veya yaş arttıkça, COVID-19 aşısı eksik, kırgınlık-yorgunlukla test yaptıran, solunum sıkıntısı veya günlük stres yaşayan, hipertansiyon, kanser, diyabet, koroner arter veya diğer kalp damar hastalığı olanlarda hastaneye yatış yüksek bulunmuştur (p<0,05). Hastalığı geçirirken vitamin kullanan veya post-COVID-19 asemptomatiklerde hastaneye yatış düşük bulunmuştur (p<0,05). Post-COVID-19 döneme; hastaneye yatış, aşı, sigarayı bırakmış olma, süreğen hastalıklar etkili bulunmuştur (p<0,05). COVID-19’da en sık yaşantı değişikliği sosyal izolasyon %21,11, hissedilen halsizlik-yorgunluk-kırgınlık %25,53, hastalığı geçirirken yapılan dinlenmek-yatmak %51,59, stres nedeni korku %50,40 saptanmıştır. Öğrenim, obezite, yaş, sigara, süreğen hastalık, sürekli ilaç, aşılar, kırgınlık yorgunlukla test yaptırma, solunum sıkıntısı, gün içinde stres yaşama, vitaminler, post-COVID-19 asemptomatik olma kliniğe; aşılar, sigara, hastaneye yatış, sürekli hastalık, hipertansiyon, diyabetes mellitus, astım, tiroid hastalığı, romatizma hastalığı post-COVID-19 değişikliklere etki etmektedir. Bu çalışma, COVID-19 hastalığı için korunma, takip ve risk gruplarının tespitini kolaylaştırabilir, çalışmalara ışık tutabilir.
Güncel Epigenetik Tedaviler
Authors: Seven Didem
Published: September 2024

Epigenetik mekanizmalar, histon modifikasyonları, DNA metilasyonları ve kodlanmayan RNA’lar aracılığı ile DNA dizisinde herhangi bir değişiklik göstermeksizin, gen ifade düzeylerinin değişmesi olarak tanımlanmaktadır. Yapılan araştırmalar, epigenetik değişikliklerin birçok hastalığın patogenezinde etkin olduğunu göstermiş, bazı hastalıkların tanı ve prognozunda etkili biyobelirteçler tespit edilmiştir. Belirlenen biyobelirteçlerin hedeflenerek klinik çalışmalarda araştırılması devam ederken, kimi epigenetik tedavi araçları FDA onayı ile tedavide kullanılmaktadır. Histon deasetilaz inhibitörleri, DNA metil transferaz inhibitörleri ve kodlanmayan RNA’lar başta kanser olmak üzere tekli veya kombine olarak birçok hastalığın patogenezinde tedavi amaçlı kullanılmaktadır. Her ne kadar epigenetik tedavilerin kabul görmesi zaman almış olsa da, etkinliği kanıtlanmıştır ve günümüzde tek veya kombine terapi olarak klinikte uygulanmaktadır. Bu sebeple epigenetik mekanizmaların aydınlatılarak hedeflerinin ve düzenleyicilerinin belirlenmesi ve bu hedeflerin işlevlerinin araştırılması önem arz etmektedir. Bu derlemede rutin klinik uygulamada kullanılan, FDA onayı almış ve klinik araştırmalarda sıklıkla kullanılan epigenetik terapiler özetlenecektir.
Strategi Komunikasi Corporate Social and Responsibility PT. Siringo-Ringo Rantauprapat Dalam Pemberdayaan Masyarakat di Sekitar Lingkungan Perusahaan
Authors: Lestari Iko Ayu
Published: September 2024

This research analyzes the Corporate Social Responsibility (CSR) practices at PT. Siringo-Ringo with a focus on community empowerment in the village of Bandar Kumbul. The research method employed is qualitative with a case study approach. The findings indicate that PT. Siringo-Ringo has successfully implemented a holistic CSR program, involving local stakeholders such as village government, community leaders, and the local populace. The CSR program encompasses various areas including education, economics, and community empowerment. This research provides in-depth insights into the positive impacts generated by PT. Siringo-Ringo's CSR program on the company's relationship with the community and local welfare. The implications of these research findings suggest that the qualitative approach offers a profound understanding of CSR dynamics and contributions within the specific context of the company and its local environment.