bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S5 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: April 2023

Supplementary Figure S5 PDF File - 48K, Inactivation of Arkadia perturbs the TGF-�-regulated transcriptional response of MDA-MB-231 cells at 1h and 24h post TGF-� stimulation
Supplementary Figure 1 from Earlier Detection of Breast Cancer with Ultrasound Molecular Imaging in a Transgenic Mouse Model
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Lutz Amelie M. , Gambhir Sanjiv S. , Tranquart Francois , Tian Lu , Willmann Jürgen K.
Published: April 2023

PDF file - 1480K, Box Plot summarizing the angiogenesis score obtained for the four different histological stages (normal, hyperplasia, DCIS and invasive) of breast cancer).
Supplementary Table 1 from CHD1 Is a 5q21 Tumor Suppressor Required for ERG Rearrangement in Prostate Cancer
Authors: Burkhardt Lia , Fuchs Sarah , Krohn Antje , Masser Sawinee , Mader Malte , Kluth Martina , Bachmann Frederik , Huland Hartwig , Steuber Thomas , Graefen Markus , Schlomm Thorsten , Minner Sarah , Sauter Guido , Sirma Hüseyin , Simon Ronald
Published: April 2023

PDF file - 101K, GISTIC analysis of genomic rearrangements (cytoband) significantly associated with 5q21 deletion. The cytobands, significance (q value) and peak boundaries are indicated.
Supplementary Figure Legend from Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation
Authors: Lee Cleo Yi-Fang , Lin Yuan , Bratman Scott V. , Feng Weiguo , Kuo Angera H. , Scheeren Ferenc A. , Engreitz Jesse M. , Varma Sushama , West Robert B. , Diehn Maximilian
Published: April 2023

PDF file - 153K
Supplementary Data from BRMS1 Suppresses Lung Cancer Metastases through an E3 Ligase Function on Histone Acetyltransferase p300
Authors: Liu Yuan , Mayo Marty W. , Nagji Alykhan S. , Hall Emily H. , Shock Lisa S. , Xiao Aizhen , Stelow Edward B. , Jones David R.
Published: April 2023

Supplementary Data PDF file - 682K, SD Fig.1 NSCLC H157 cells stably expressed GFP-BRMS1 (BRMS1) or empty vector (Control) were transfected with vector encoding HA-p300 or empty vector (CMV). SD Fig.2 H1299 cells were co-transfected with siRNA BRMS1 or siRNA nontargeting sequences (Left), or HA-BRMS1 or empty vector (CMV, Right), and Flag-tagged p/CAF. The expression of Flag-p/CAF was assessed. SD Fig.3 (A) and (B) None of the lysine residues in the 2042-2157aa region of p300 is responsible for BRMS1-mediated degradation. SD Fig.4 (A) HEK 293T cells were co-transfected with HA-tagged p300 (617-2414) and the indicated HA-tagged BRMS1 or empty vector. SD Fig.5 (A) BRMS1 E3 mutant enhances the invasion potential of NSCLC. The invasion capability of NSCLC H157 and H1299 BRMS1 WT and E3M cells was assessed using invasion assays as described previously (Smith. PW Cancer lett 2009)
Supplementary Figure 7 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: April 2023

PDF file - 29K, Computational modeling of clinical response to therapy.
Supplementary Figures 1 and 2 from Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer
Authors: Cheng Pingyan , Kumar Vinit , Liu Hao , Youn Je-In , Fishman Mayer , Sherman Simon , Gabrilovich Dmitry
Published: April 2023

PDF - 1296K, The phenotype of cells in TB mice and generated from HPC in the presence of TCM (S1); Typical example of the phenotype of cells generated from HPC after 7-day culture on immobilized Dll1 or control IgG in the presence of TCM (S2).
Supplementary Figure 2 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: April 2023

PDF file - 66K, Loss of membrane motion is an early event in cell death, preceding loss of membrane integrity.
Supplementary Figure Legend from Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity
Authors: Risinger A.L. , Li J. , Bennett M.J. , Rohena C.C. , Peng J. , Schriemer D.C. , Mooberry S.L.
Published: April 2023

PDF file - 62K
Supplementary Table S1 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: April 2023

Supplementary Table S1 PDF file 125K, Immunohistochemical staining and FISH results of UHGPS
Supplementary Figure 1 from Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity
Authors: Risinger A.L. , Li J. , Bennett M.J. , Rohena C.C. , Peng J. , Schriemer D.C. , Mooberry S.L.
Published: April 2023

PDF file - 225K, High magnification electron micrographs (20,000x and 50,000x) of microtubules formed in the presence of 2 mg/ml tubulin with 10 microM AJ, PTX or LAU 60 min after tubulin reactions were warmed to 37 degrees C.
Supplementary Figure 5 from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: April 2023

PDF file - 76K, Supplemental Figure 5. Negative controls of pACC immunohistochemistry in human glioblastoma tissue samples.
Supplementary Figure 2 from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: April 2023

PDF file - 122K, Supplemental figure 2: Oncogenic events induced an increase in AMPK nuclear localization and Rb phosphorylation, while mTOR pathway is maintained at low level of activation.
Supplementary Table 1 from MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer
Authors: MacNeil Adam J. , Jiao Shun-Chang , McEachern Lori A. , Yang Yong Jun , Dennis Amanda , Yu Haiming , Xu Zhaolin , Marshall Jean S. , Lin Tong-Jun
Published: April 2023

XLSX file - 27K, Supplementary Table S1. Clinical grading and tumour marker profile information.
Supplementary Figure S5 from Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer
Authors: Camps Jordi , Pitt Jason J. , Emons Georg , Hummon Amanda B. , Case Chanelle M. , Grade Marian , Jones Tamara L. , Nguyen Quang T. , Ghadimi B. Michael , Beissbarth Tim , Difilippantonio Michael J. , Caplen Natasha J. , Ried Thomas
Published: April 2023

Supplementary Figure S5 PDF file - 1693K,Reproducibility of siRNA-induced signature gene expression changes for the eight candidate genes
Supplementary Figure 1 from CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions
Authors: Franciszkiewicz Katarzyna , Le Floc'h Audrey , Boutet Marie , Vergnon Isabelle , Schmitt Alain , Mami-Chouaib Fathia
Published: April 2023

PDF file - 127K, Surface expression of E-cadherin (CD324) and ICAM-1 (CD54) on IGR-Heu tumor cells.
Supplementary Figure 1 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 155K, Mouse macrophage chemotaxis induced by classical chemoattractants
Supplementary Figure 3 from Chemotherapy Acts as an Adjuvant to Convert the Tumor Microenvironment into a Highly Permissive State for Vaccination-Induced Antitumor Immunity
Authors: Kang Tae Heung , Mao Chih-Ping , Lee Sung Yong , Chen Alexander , Lee Ji-Hyun , Kim Tae Woo , Alvarez Ronald D. , Roden Richard B.S. , Pardoll Drew , Hung Chien-Fu , Wu T.-C.
Published: April 2023

PDF file - 2370K, Effect of chemotherapy on the frequency of CD11b+ Gr-1+ myeloid-derived suppressor cells (MDSCs)
Supplementary Figure 6 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 31K, Migration of MG1361 cells in boyden chamber assays correlated with Bcl3 mRNA levels
Supplementary Figure 4 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 85K, Pubertal development of the mammary gland is unaffected by Bcl3 deletion
Supplementary Figure 3 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 193K, Bcl3 deficiency has no effect on pre-neoplastic tissue homeostasis
Supplementary Materials and Methods from LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Authors: Cox Thomas R. , Bird Demelza , Baker Ann-Marie , Barker Holly E. , Ho Melisa W-Y. , Lang Georgina , Erler Janine T.
Published: April 2023

Supplementary Materials and Methods PDF file - 79K, Detailed descriptions of experimental conditions
Supplementary Table 1 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: April 2023

PDF file - 54K, Mutations analysis in primary leukemia blasts.
Supplementary Tables 1 - 4 from The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Authors: Listerman Imke , Sun Jie , Gazzaniga Francesca S. , Lukas Jason L. , Blackburn Elizabeth H.
Published: April 2023

PDF file - 516K, T1. Breast cell lines used in this study. T2. Summary of results for 45 breast cancer cell lines and 5 non-malignant cell lines. T3. Correlation of hTERT α/β splice variants, telomerase activity, telomere length and hTR in 50 breast cancer cell lines. T4. Sequences of primers used.
Supplementary Figures 1 - 7 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: April 2023

PDF file - 579K, Supplemantary Figure 1: Bcl-2 and Bcl-xL determine sensitivity to PI3K/AKT/mTOR inhibition. Supplementary Figure 2: AKT modulates sensitivity to ABT-737. Supplementary Figure 3: BEZ235/ABT-737 results in time-dependent induction of apoptosis. Supplementary Figure 4: PI3K inhibitors markedly increase Bim binding to Bcl-2 and Bcl-xL. Supplementary Figure 5: Overexpression of Bcl-2 or Bcl-xL protects leukemia cells against BEZ235/ABT-737 lethality Supplementary Figure 6: GSK3 inhibitors protect cells against BEZ235/ABT-737 lethality Supplementary Figure 7: In vivo anti-leukemic activity of BEZ235/ABT-737.
Supplementary Methods and Figures 1 - 4 from Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
Authors: Masica David L. , Karchin Rachel
Published: April 2023

PDF file - 534K, Supporting material for this manuscript includes four supplementary files: a detailed description of all methods and implementation (Supplementary methods); an excel spreadsheet containing all pairwise interactions, grouped by data type (Supplemental pairwise interactions); an excel spreadsheet containing all three-body set interactions, grouped by drug (Supplemental set interactions); and code used to produce all results from this manuscript, including detailed instructions for execution (44).
Supplementary Figures 1 - 7 from Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche
Authors: Infanger David W. , Cho YouJin , Lopez Brina S. , Mohanan Sunish , Liu S. Chris , Gursel Demirkan , Boockvar John A. , Fischbach Claudia
Published: April 2023

PDF file - 1076K, Immunofluorescence staining of GBM CSCs cultured in the presence of serum and absence of EGF and bFGF (S1); Tumors formed from CSC-seeded PLG scaffold implantation exhibit clinical features of human GBM (S2); Vascular characteristics of tumors formed from PLG scaffold implantation (S3); CSC differentiation is impaired by 3-D hCMEC paracrine signaling cues (S4); Control experiments evaluating IL-8-induced chemotaxis and gene expression in CSCs (S5); Targeted knockdown of CXCR2 in GBM CSCs (S6); Tumor vascularization was not affected by siRNA-knockdown of IL-8 in CSCs (S7).
Supplementary Figure Legend from EGFR-TKI Resistance Due to BIM Polymorphism Can Be Circumvented in Combination with HDAC Inhibition
Authors: Nakagawa Takayuki , Takeuchi Shinji , Yamada Tadaaki , Ebi Hiromichi , Sano Takako , Nanjo Shigeki , Ishikawa Daisuke , Sato Mitsuo , Hasegawa Yoshinori , Sekido Yoshitaka , Yano Seiji
Published: April 2023

PDF file - 89K
Supplementary Figure 4 from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: April 2023

PDF file - 139KB, mRNA expression signal intensities in stem cells from the duodenum of Lgr5 Cre+ Catnblox(deltaex3) Klf5+/+ mice (x-axis, log) and Lgr5 Cre+ Catnblox(deltaex3) Klf5delta/delta mice (yaxis, log).
Supplementary Figure 3 from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: April 2023

PDF file - 36KB, Mating strategy for generating Lgr5 Cre+ Catnb+/lox(ex3) Klf5flox/flox mice. Lgr5 Cre+ (Lgr5-EGFP-ires-CreERT2) mice had the activation of Cre recombinase, specific in Lgr5+ intestinal epithelial stem cells, by the intraperitoneal medication of Tamoxifen.
Supplementary Figure 1 from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: April 2023

PDF file - 674KB, Experimental design for the sorting of stem cells and TA cells from the duodenum of Lgr5-GFP-IRES-CreERT mice (Lgr5 Cre+ Catnb+/lox(ex3) Klf5flox/flox, Lgr5 Cre+ Catnb+/lox(ex3) Klf5+/+, and Lgr5 Cre+ Klf5flox/flox) for mRNA expression microarray analysis.
Supplementary Figure 2 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: April 2023

PDF file - 848K, Supplementary Figure 2: Inhibition of mTORC1 activates EMT and reduces cell proliferation.
Supplementary Figure 2 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL
Authors: Zhou Zheng-Jun , Dai Zhi , Zhou Shao-Lai , Hu Zhi-Qiang , Chen Qing , Zhao Yi-Ming , Shi Ying-Hong , Gao Qiang , Wu Wei-Zhong , Qiu Shuang-Jian , Zhou Jian , Fan Jia
Published: April 2023

PDF file - 110K, Supplementary Figure S2. The effect of hnRNPAB on tumor growth and metastasis in vivo.
Suppl Material & Suppl. Table S1 from Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Authors: Rani Sweta , Corcoran Claire , Shiels Liam , Germano Serena , Breslin Susan , Madden Stephen , McDermott Martina S. , Browne Brigid C. , O'Donovan Norma , Crown John , Gogarty Martina , Byrne Annette T. , O'Driscoll Lorraine
Published: April 2023

Suppl Material & Suppl. Table S1
Supplementary Figure 5 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: April 2023

PDF file - 111K, deltaNp63alpha regulates migration, VEGF and HRE promoter activity in a STAT3-dependent manner.
Suppl Fig. S1 from Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Authors: Rani Sweta , Corcoran Claire , Shiels Liam , Germano Serena , Breslin Susan , Madden Stephen , McDermott Martina S. , Browne Brigid C. , O'Donovan Norma , Crown John , Gogarty Martina , Byrne Annette T. , O'Driscoll Lorraine
Published: April 2023

Suppl Fig. S1
Supplementary Table 3 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Authors: Cecil Denise L. , Holt Gregory E. , Park Kyong Hwa , Gad Ekram , Rastetter Lauren , Childs Jennifer , Higgins Doreen , Disis Mary L.
Published: April 2023

PDF file - 50KB, Human protein sequence homologies for IGFBP-2 N-terminus.
Supplementary Figures 1 - 4 from Dual Functions of the Homeoprotein DLX4 in Modulating Responsiveness of Tumor Cells to Topoisomerase II-Targeting Drugs
Authors: Trinh Bon Q. , Ko Song Yi , Barengo Nicolas , Lin Shiaw-Yih , Naora Honami
Published: April 2023

PDF file - 444K, S1 TOP2A transcript levels in ovarian and lung cancers stratified by DLX4 expression. S2 Overexpression and knockdown of TOP2. S3 DLX4 does not stimulate HR-mediated repair of DSBs. S4 DLX4 increases the magnitude of erroneous end-joining repair of DSBs.
Supplementary Figure 3 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: April 2023

PDF file - 197K, The pGL4luc2P-NRF2-ARE-Hygro construct (Promega)
Supplementary Figure 4 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: April 2023

PDF file - 358K, In vitro viability of NB4, NCI-H460 and MDA-MB-231 cells � NTR � CytoCy5S.
Supplementary Figure 6 from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: April 2023

PDF file - 446K, Supplemental Figure 6 Immunohistochemistry for Nox4 and HIF-2alpha in 786-0 NS and KD xenograft explants confirms re-expression of Nox4 in KD tumors with corresponding elevated HIF-2alpha expression. Magnification 200X.
Supplementary Figure 5 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: April 2023

PDF file - 89K, A. Gene expression profiles of widely used breast tumour cell lines were extracted from three different data sets, normalised and clustered into the designated molecular subtypes. The expression of PIP4K2A, 2B and 2C are graphically shown below. B. Box plots representing the expression of PIP4K2B in the three molecular subtypes determine by cluster analysis. C. Expression of PIP4K2B in normal cells (MCF10A) and luminal cells (MCF7) and ERBB2 positive cells (ZR-75).
Supplementary Figure 2 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: April 2023

PDF file - 383K, Cells as indicated were fixed and embedded in paraffin and sections were cut and mounted. The sections were stained with the PIP4K2BP6 antibody after antigen retrieval.
Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Authors: Santo Evan E. , Stroeken Peter , Sluis Peter V. , Koster Jan , Versteeg Rogier , Westerhout Ellen M.
Published: April 2023

Supplementary Figure and Table Legends PDF file - 63K, Legend for Supplementary Figures S1-S5 and Supplementary Table S1
Supplementary Figure 2 from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: April 2023

PDF file - 77K, Src activity in SmoM2 induced skin neoplasia
Supplementary Figure 4 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: April 2023

PDF file - 251K, Discriminating chronotoxicity Classes based on selected circadian mRNA gene expressions in liver and colon mucosa.
Supplementary Figure 7 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 372K, iNGR enhances tumor penetration of Evans Blue dye
Supplementary Table 3 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication
Authors: de Leeuw David C. , Denkers Fedor , Olthof Marjolein C. , Rutten Arjo P. , Pouwels Walter , Jan Schuurhuis Gerrit , Ossenkoppele Gert J. , Smit Linda
Published: April 2023

XLSX file - 15KB, MicroRNAs differentially expressed between LSC and HSC (at least 2 out of 3 patients): Upper: MicroRNA expression ratios between CD34+CD38-ALDHlow/dim(LSC) and CD34+CD38-ALDHhigh (HSC) populations obtained from microarray analysis. The average ratio is calculated over all 3 analyzable patients. Number of patients indicate the number of patients that show significant differential expression for that microRNA. Lower: Average and standard deviations of all ratios between LSC and HSC per patient. 'Average + Stdev' and 'Average - Stdev', average plus or minus one time the standard deviation for each individual patient indicate the values used as cutoff for significant microRNAs per patients. Italic printed ratios represent non-significant microRNAs for that individual patient.
Supplementary Tables 1 - 2 from Intratumoral Modeling of Gefitinib Pharmacokinetics and Pharmacodynamics in an Orthotopic Mouse Model of Glioblastoma
Authors: Sharma Jyoti , Lv Hua , Gallo James M.
Published: April 2023

PDF file - 94K, Supplementary Table S1. PK parameters of gefitinib in plasma, normal brain and brain tumor in U87VIII intracerebral tumor bearing athymic mice receiving single oral 50 mg/kg and 150 mg/kg doses of gefitinib. Parameters were obtained by noncompartmental analysis of data from all the mice (n=3 at each time point) at each dose level. Supplementary Table S2. Intratumoral variability in gefitinib concentrations in LN229VIII-PTEN Brain Tumor Model in Mice Following a Single Oral Dose of 150mg/kg.
Supplementary Table 1 from Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma
Authors: Liao Rachel G. , Jung Joonil , Tchaicha Jeremy , Wilkerson Matthew D. , Sivachenko Andrey , Beauchamp Ellen M. , Liu Qingsong , Pugh Trevor J. , Pedamallu Chandra Sekhar , Hayes D. Neil , Gray Nathanael S. , Getz Gad , Wong Kwok-Kin , Haddad Robert I. , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF file - 80K, Patient details in lung SqCC patients containing FGFR mutations.
Supplementary Figure 5 from PP2A-B55β Antagonizes Cyclin E1 Proteolysis and Promotes Its Dysregulation in Cancer
Authors: Tan YingMeei , Sun Dahui , Jiang Weijian , Klotz-Noack Kathleen , Vashisht Ajay A. , Wohlschlegel James , Widschwendter Martin , Spruck Charles
Published: April 2023

PDF file - 212KB, Representative gene expression studies demonstrating overexpression of PPP2R2B in human cancers. Data obtained from the ONCOMINE database (2).
Supplementary Figure 4 from Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Authors: Kwong Lawrence N. , Chin Lynda
Published: April 2023

PDF file - 35KB, Phenotypes of human melanoma cell lines with knocked down or overexpressed Ablim1.
Supplementary Figure 3 from Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Authors: Kwong Lawrence N. , Chin Lynda
Published: April 2023

PDF file - 603KB, Tumor growth in allografts.
Supplementary Table 3 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 191K, Antibodies used in the study.
Supplementary Figure S5 from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Inhibition of NFkB activities in APN-conditioned mDCs is dependent on STAT3 and SOCS3 pathway.
Supplementary Figure 6 from microRNA-148a Is a Prognostic oncomiR That Targets MIG6 and BIM to Regulate EGFR and Apoptosis in Glioblastoma
Authors: Kim Jungeun , Zhang Ying , Skalski Michael , Hayes Josie , Kefas Benjamin , Schiff David , Purow Benjamin , Parsons Sarah , Lawler Sean , Abounader Roger
Published: April 2023

PDF file - 17K, BIM mediates the effects of miR-148a on aopotosis.
Supplementary Figure 2 from microRNA-148a Is a Prognostic oncomiR That Targets MIG6 and BIM to Regulate EGFR and Apoptosis in Glioblastoma
Authors: Kim Jungeun , Zhang Ying , Skalski Michael , Hayes Josie , Kefas Benjamin , Schiff David , Purow Benjamin , Parsons Sarah , Lawler Sean , Abounader Roger
Published: April 2023

PDF file - 247K, Transfection efficiency of U87 cells infected with lentiviruses encoding anti-miR-148, mCherry, and hygromycin resistance gene.
Supplementary Figure 1 from microRNA-148a Is a Prognostic oncomiR That Targets MIG6 and BIM to Regulate EGFR and Apoptosis in Glioblastoma
Authors: Kim Jungeun , Zhang Ying , Skalski Michael , Hayes Josie , Kefas Benjamin , Schiff David , Purow Benjamin , Parsons Sarah , Lawler Sean , Abounader Roger
Published: April 2023

PDF file - 30K, miR-148a levels after transfection with pre-miR-148a.
Supplementary Figure Legend from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

PDF file - 64K
Supplementary Figure 3 from VISTA Is an Immune Checkpoint Molecule for Human T Cells
Authors: Lines J. Louise , Pantazi Eirini , Mak Justin , Sempere Lorenzo F. , Wang Li , O'Connell Samuel , Ceeraz Sabrina , Suriawinata Arief A. , Yan Shaofeng , Ernstoff Marc S. , Noelle Randolph
Published: April 2023

PDF file - 90KB, Human and mouse VISTA-Ig show titratable suppressive activity on human CD4 T cells. Bulk CD4 T cells were purified from human PBMCs by magnetic bead selection. Cells were labeled with CFSE, and stimulated for 5 days with 1, 2.5 or 5ug/ml of anti-CD3 co-coated with 0, 2.5, 5, or 10ug/ml of human (a and c) or mouse (b and d) VISTA-Ig. Control-Ig was added to equalize the amount of fusion protein. (a and b) Overlays showing representative CFSE profiles. Cells are gated on live, singlet CD4 positive cells. (c and d) Percentage CFSE low cells are shown as mean +/- SD. *p<0.05, **p<0.01, ***p<0.001. Data is representative of two separate experiments.
Supplementary Figure 4 from Curative Properties of Noninternalizing Antibody–Drug Conjugates Based on Maytansinoids
Authors: Perrino Elena , Steiner Martina , Krall Nikolaus , Bernardes Gonçalo J.L. , Pretto Francesca , Casi Giulio , Neri Dario
Published: April 2023

PDF file - 102KB, Supplementary figure 4: BIAcore analysis.
Supplementary Materials and Methods from DDB2: A Novel Regulator of NF-κB and Breast Tumor Invasion
Authors: Ennen Marie , Klotz Rémi , Touche Nadège , Pinel Sophie , Barbieux Claire , Besancenot Vanessa , Brunner Emilie , Thiebaut Denise , Jung Alain C. , Ledrappier Sonia , Domenjoud Lionel , Abecassis Joseph , Plénat François , Grandemange Stéphanie , Becuwe Philippe
Published: April 2023

PDF - 90K, Additional information regarding antibodies, western blot, immunocytofluorescence analysis, and quantitative real-time RT-PCR analysis.
Supplementary Figure Legends, Table 1 from WEE1 Inhibition Alleviates Resistance to Immune Attack of Tumor Cells Undergoing Epithelial–Mesenchymal Transition
Authors: Hamilton Duane H. , Huang Bruce , Fernando Romaine I. , Tsang Kwong-Yok , Palena Claudia
Published: April 2023

PDF file - 92KB, Supplementary Table 1. Real-time PCR assays and PCR primers utilized.
Supplementary Figure 5 from WEE1 Inhibition Alleviates Resistance to Immune Attack of Tumor Cells Undergoing Epithelial–Mesenchymal Transition
Authors: Hamilton Duane H. , Huang Bruce , Fernando Romaine I. , Tsang Kwong-Yok , Palena Claudia
Published: April 2023

PDF file - 79KB, Schematic model of the proposed mechanism.
Supplementary Figure 9 from HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer
Authors: Rath Kellie S. , Naidu Shan K. , Lata Pushpa , Bid Hemant K. , Rivera Brian K. , McCann Georgia A. , Tierney Brent J. , ElNaggar Adam C. , Bravo Veronica , Leone Gustavo , Houghton Peter , Hideg Kálmán , Kuppusamy Periannan , Cohn David E. , Selvendiran Karuppaiyah
Published: April 2023

PDF file - 172K, EPR spectra from organ tissue samples obtained from HO-3867-treated mice.
Supplementary Figure 7 from HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer
Authors: Rath Kellie S. , Naidu Shan K. , Lata Pushpa , Bid Hemant K. , Rivera Brian K. , McCann Georgia A. , Tierney Brent J. , ElNaggar Adam C. , Bravo Veronica , Leone Gustavo , Houghton Peter , Hideg Kálmán , Kuppusamy Periannan , Cohn David E. , Selvendiran Karuppaiyah
Published: April 2023

PDF file - 156K, Effect of H-4073 in both cancer and normal cells. Phosphokinase assay array using CHO cells.
Supplementary Figure 6 from Accumulation of Cytosolic Calcium Induces Necroptotic Cell Death in Human Neuroblastoma
Authors: Nomura Motonari , Ueno Ayumi , Saga Kotaro , Fukuzawa Masahiro , Kaneda Yasufumi
Published: April 2023

PDF - 61K, HVJ-E-induced cell death in SK-N-SH cells is not mediated by the TNF receptor.
Supplementary Figure 4 from HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer
Authors: Rath Kellie S. , Naidu Shan K. , Lata Pushpa , Bid Hemant K. , Rivera Brian K. , McCann Georgia A. , Tierney Brent J. , ElNaggar Adam C. , Bravo Veronica , Leone Gustavo , Houghton Peter , Hideg Kálmán , Kuppusamy Periannan , Cohn David E. , Selvendiran Karuppaiyah
Published: April 2023

PDF file - 220K, Representative Annexin V flow cytomety plots of CHO, H9c2 and A2780 cells.
Supplementary Figure 11 from HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer
Authors: Rath Kellie S. , Naidu Shan K. , Lata Pushpa , Bid Hemant K. , Rivera Brian K. , McCann Georgia A. , Tierney Brent J. , ElNaggar Adam C. , Bravo Veronica , Leone Gustavo , Houghton Peter , Hideg Kálmán , Kuppusamy Periannan , Cohn David E. , Selvendiran Karuppaiyah
Published: April 2023

PDF file - 163K, Representative Annexin V flow cytomety plots of chemotherapy-resistant primary cell lines.
Supplementary Figure 1 from HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer
Authors: Rath Kellie S. , Naidu Shan K. , Lata Pushpa , Bid Hemant K. , Rivera Brian K. , McCann Georgia A. , Tierney Brent J. , ElNaggar Adam C. , Bravo Veronica , Leone Gustavo , Houghton Peter , Hideg Kálmán , Kuppusamy Periannan , Cohn David E. , Selvendiran Karuppaiyah
Published: April 2023

PDF file - 138K, Image of H-4073 docked with the STAT3 monomer and STAT3 translocation assay.
Supplementary Table 1 from Activation of the FGFR–STAT3 Pathway in Breast Cancer Cells Induces a Hyaluronan-Rich Microenvironment That Licenses Tumor Formation
Authors: Bohrer Laura R. , Chuntova Pavlina , Bade Lindsey K. , Beadnell Thomas C. , Leon Ronald P. , Brady Nicholas J. , Ryu Yungil , Goldberg Jodi E. , Schmechel Stephen C. , Koopmeiners Joseph S. , McCarthy James B. , Schwertfeger Kathryn L.
Published: April 2023

PDF file - 38K, Proportional odds logistic regression results evaluating the association between pSTAT3 and pFRS2.
Supplementary information from hSETD1A Regulates Wnt Target Genes and Controls Tumor Growth of Colorectal Cancer Cells
Authors: Salz Tal , Li Guangyao , Kaye Frederic , Zhou Lei , Qiu Yi , Huang Suming
Published: April 2023

PDF file 316K, Supplementary Figure S1: Both hSETD1A and hSETD1B are up-regulated in human CRC. Supplementary Figure S2: hSETD1A modulates H3K4me3 levels and controls cellular growth. Supplementary Figure S3: The loss of hSETD1A does not induce apoptosis. Supplementary Figure S4: The loss of hSETD1A decreases H3K4me3 enrichment at the Wnt target gene promoters in CRC. Supplementary Figure S5: hSETD1A and TAF3 share a subset of key Wnt target genes. Supplementary Tables: Supplementary Table S1: Expression profile of Wnt target genes in shSETD1A HCT116 cells. Supplementary Table S2: Human ChIP primers used in this study. Supplementary Table S3: Human RT-PCT primers used in this study. Supplementary Table S4: Human shRNA used in this study
Supplementary Table 2 from Expression of Variant Isoforms of the Tyrosine Kinase SYK Determines the Prognosis of Hepatocellular Carcinoma
Authors: Hong Jian , Yuan Yunfei , Wang Jianping , Liao Yadi , Zou Ruhai , Zhu Chuanlong , Li Binkui , Liang Yi , Huang Pinzhu , Wang Zongwei , Lin Wenyu , Zeng Yixin , Le Dai Jia , Chung Raymond T.
Published: April 2023

PDF file - 83KB, Supplementary Table 2. Univariate prognostic analyses of recurrence and OS rates for 152 HCC patients after hepatectomy.
Supplementary Figure 7 from Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer
Authors: Nagalingam Arumugam , Kuppusamy Panjamurthy , Singh Shivendra V. , Sharma Dipali , Saxena Neeraj K.
Published: April 2023

PDF file - 126KB, Supplemental Figure 7 Withaferin A induces phosphorylation of Elk1 in ERK-dependent manner.
Supplementary Figure 5 from Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer
Authors: Nagalingam Arumugam , Kuppusamy Panjamurthy , Singh Shivendra V. , Sharma Dipali , Saxena Neeraj K.
Published: April 2023

PDF file - 112KB, Supplemental Figure 5 WFA activates RSK in an ERK-dependent manner. ERK and RSK activation is important for WFA-mediated cleavage of apoptotic marker, PARP.
Supplementary Figure 1 from Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer
Authors: Nagalingam Arumugam , Kuppusamy Panjamurthy , Singh Shivendra V. , Sharma Dipali , Saxena Neeraj K.
Published: April 2023

PDF file - 131KB, Supplemental Figure 1 Withaferin A inhibits cell viability of breast cancer cells.
Supplementary Figures 1 - 6 from MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors
Authors: Luraghi Paolo , Reato Gigliola , Cipriano Elia , Sassi Francesco , Orzan Francesca , Bigatto Viola , De Bacco Francesca , Menietti Elena , Han May , Rideout William M. , Perera Timothy , Bertotti Andrea , Trusolino Livio , Comoglio Paolo M. , Boccaccio Carla
Published: April 2023

PDF file - 8193K, Supplementary Figure S1. Xensophere characterization. Supplementary Figure S2. EGF in Raswt xenosphere proliferation. Supplementary Figure S3. MET inhibition in xenospheres treated with FCM. Supplementary Figure S4. HGF dose-response in RASwt xenosphere viability. Supplementary Figure S5. M049 spheropatient treatment and HGF autocrine loop in M049 xenosphere. Supplementary Figure S6. CC-IC marker expression in M049 xenospheres and spheropatients treated with inhibitors.
Data Supplement from Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis
Authors: Esteves Pauline , Pecqueur Claire , Ransy Céline , Esnous Catherine , Lenoir Véronique , Bouillaud Frédéric , Bulteau Anne-Laure , Lombès Anne , Prip-Buus Carina , Ricquier Daniel , Alves-Guerra Marie-Clotilde
Published: April 2023

Supplemental Materials and Methods
Supplementary Figure S5 from Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
Authors: Gallot Yann S. , Durieux Anne-Cécile , Castells Josiane , Desgeorges Marine M. , Vernus Barbara , Plantureux Léa , Rémond Didier , Jahnke Vanessa E. , Lefai Etienne , Dardevet Dominique , Nemoz Georges , Schaeffer Laurent , Bonnieu Anne , Freyssenet Damien G.
Published: April 2023

Lifespan of wild-type and Mstn-/- mice - Number of polyps.
Supplementary Figure Legends from Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Authors: Gopal Y.N. Vashisht , Rizos Helen , Chen Guo , Deng Wanleng , Frederick Dennie T. , Cooper Zachary A. , Scolyer Richard A. , Pupo Gulietta , Komurov Kakajan , Sehgal Vasudha , Zhang Jiexin , Patel Lalit , Pereira Cristiano G. , Broom Bradley M. , Mills Gordon B. , Ram Prahlad , Smith Paul D. , Wargo Jennifer A. , Long Georgina V. , Davies Michael A.
Published: April 2023

Supplementary Figure Legends. This file contains the text legends that describe the data presented in the supplementary figures.
Supplementary Video 1 from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: April 2023

Live cell microscopy of MDA-MB-468 inducibly expressing FLAG-HA-BAP1 and transiently transfected with H2B-GFP.
Supplementary Figures 1 - 6 from Deubiquitination of γ-Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells
Authors: Zarrizi Reihaneh , Menard Julien Albert , Belting Mattias , Massoumi Ramin
Published: April 2023

Supplementary Figure 1. The cellular distribution of gamma-tubulin and BRCA1 in MCF10A cells, using immunofluorescence staining and confocal microscopy. Bars, 10 mm. Supplementary Figure 2. Confidence view screenshot from STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) shows known and predicted protein-protein interaction network of human BAP1 and UCHL1, as well as gamma tubulin (TUBG1) and BRCA1, which were used as inputs to the query. Supplementary Figure 3. (A)The subcellular distribution of endogenous BAP1 in MCF10A cells, using immunofluorescence staining and confocal microscopy.(B) The subcellular localization of BAP1 in MCF10A cells were biochemically divided into cytosolic (Cyto), Nuclear membrane (NM) and Nucleus (Nu) fractions and examined by Western blotting with an anti-BAP1 antibody. alpha-tubulin and Lamin B were used as molecular markers for the cytosolic and Nucleus fractions, respectively. Supplementary Figure 4. (A) Immunoprecipitation of endogenous alpha-tubulin from synchronized MCF10A cells and immunoblotting using UCHL1 and alpha-tubulin antibodies. The arrowhead points to a shift in size of alpha-tubulin corresponding to ubiquitinated alpha-tubulin.MCF10A cells were synchronized by double-thymidine block release and collected in G1, S and G2/M phases. (B) MCF10A cells were synchronized by a double thymidine block. Cells in mitotic phase were obtained by nocodazole treatment (M0) and released from nocodazole after 45 min (M1), 90 min (M2), and 180 min (M3). Cell extracts were immunoprecipitated with alpha-tubulin antibody and analyzed by Western blotting using antibodies against UCHL1, alpha-tubulin, and actin. The lysate (lower panel) shows an equal amount of protein used for immunoprecipitation. Supplementary Figure 5. (A) Western blot analysis of BAP1 and Actin expression in CAMA and T47D cells. (B) Immunoprecipitation of endogenous BAP1 from synchronized CAMA and T47D cells and immunoblotting using anti-BAP1 and alpha-tubulin antibodies. Cells were synchronized by double-thymidine block release and collected in mitosis by mitotic shake-off. Both asynchronous and synchronous cell extracts were used for immunoprecipitation. The lysate (lower panel) shows an equal amount of protein used for immunoprecipitation (C) Analysis of the levels of BAP1 and ubiquitinated alpha-tubulin in CAMA and T47D cells treated for three days with shRNA against BAP1 or empty expression plasmid (shCtrl). The arrowhead points to a shift in size of alpha-tubulin corresponding to ubiquitinated alpha-tubulin. Supplementary Figure 6. (A) Western blot analysis of wild-type, Flag-HA-BAP1, using HA antibody. (B) Western blot analysis of, Flag-BAP1-C91A, using flag antibody.
Supplemental Figure S1 from Targeting Cancer Stem–like Cells as an Approach to Defeating Cellular Heterogeneity in Ewing Sarcoma
Authors: Cornaz-Buros Sandrine , Riggi Nicolo , DeVito Claudio , Sarre Alexandre , Letovanec Igor , Provero Paolo , Stamenkovic Ivan
Published: April 2023

Supplemental Figure S1. Tumor origins and specifications and primary cell characterization.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S1. Plasmid map of the pCI-neo-mCitrine expression vector.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S2. Gal-1 expression is positively correlated with histological grade in human glioma.
Supplementary Figure Legends from Adverse Immunoregulatory Effects of 5FU and CPT11 Chemotherapy on Myeloid-Derived Suppressor Cells and Colorectal Cancer Outcomes
Authors: Kanterman Julia , Sade-Feldman Moshe , Biton Moshe , Ish-Shalom Eliran , Lasry Audrey , Goldshtein Aviya , Hubert Ayala , Baniyash Michal
Published: April 2023

Legend for Supplementary Figures S1-S8.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S7. Anti-CD3ÃŽÂµ immunolabeled brain tissue sections from mouse A1 (top image) and mouse N2 (bottom image) shown in Figure 5I.
Data Supplement from Natural Killer Cells Eradicate Galectin-1–Deficient Glioma in the Absence of Adaptive Immunity
Authors: Baker Gregory J. , Chockley Peter , Yadav Viveka Nand , Doherty Robert , Ritt Michael , Sivaramakrishnan Sivaraj , Castro Maria G. , Lowenstein Pedro R.
Published: April 2023

Supplementary Figure S8. Splenic-derived RAG1-/- NK cell purity assessment.
Data Supplement from Neuronal Pentraxin 2 Supports Clear Cell Renal Cell Carcinoma by Activating the AMPA-Selective Glutamate Receptor-4
Authors: von Roemeling Christina A. , Radisky Derek C. , Marlow Laura A. , Cooper Simon J. , Grebe Stefan K. , Anastasiadis Panagiotis Z. , Tun Han W. , Copland John A.
Published: April 2023

Supplementary Figure 3. (A) QPCR for GluR4 mRNA in A498 cells infected with one of four lentiviral constructs against GluR4 (sh925, sh1676, sh2145, sh2285) as compared to NT control. (B) Western blot analysis for GluR4 expression in all four A498 GluR4 shRNA clones compared to NT control. Protein expression level quantitation is normalized to β-actin. (C) Proliferation of A498 GluR4 shRNA clones compared to NT control.
Supplemental Figure 1. In vitro phantom containing 100 μCi 177Lu. from In Vivo Localization of 90Y and 177Lu Radioimmunoconjugates Using Cerenkov Luminescence Imaging in a Disseminated Murine Leukemia Model
Authors: Balkin Ethan R. , Kenoyer Aimee , Orozco Johnnie J. , Hernandez Alexandra , Shadman Mazyar , Fisher Darrell R. , Green Damian J. , Hylarides Mark D. , Press Oliver W. , Wilbur D. Scott , Pagel John M.
Published: April 2023

Supplemental Figure 1. In vitro phantom containing 100 μCi 177Lu. Phantom images were obtained by placing a minimal volume of activity source within a 1.5 mL polypropylene tube, which was then suspended in water inside a larger polypropylene tube. This allowed simulation of Cerenkov radiation through an aquatic medium in order to more closely mimic an activity source within tissue.
Figure S7 from Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Authors: Tao Shasha , Wang Shue , Moghaddam Seyed Javad , Ooi Aikseng , Chapman Eli , Wong Pak K. , Zhang Donna D.
Published: April 2023

Figure S7. The average number of lesions (AHH+adenomas vs. adenocarcinomas).
Supplementary Figure S4 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Authors: Shimizu Takatsune , Sugihara Eiji , Yamaguchi-Iwai Sayaka , Tamaki Sakura , Koyama Yuko , Kamel Walied , Ueki Arisa , Ishikawa Tomoki , Chiyoda Tatsuyuki , Osuka Satoru , Onishi Nobuyuki , Ikeda Hiroko , Kamei Junzo , Matsuo Koichi , Fukuchi Yumi , Nagai Toshihiro , Toguchida Junya , Toyama Yoshiaki , Muto Akihiro , Saya Hideyuki
Published: April 2023

Supplementary Figure S4: (A,B) Viable AXT cells after the treatment of chemotherapeutic agents. (C) Representative flow cytometric analysis of ÃŽÂ³-H2AX abundance in AXT cells as described in Fig.4E. (D) Immunofluorescence analysis of ÃŽÂ³-H2AX in AXT cells.
Supplementary Figure S3 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Authors: Shimizu Takatsune , Sugihara Eiji , Yamaguchi-Iwai Sayaka , Tamaki Sakura , Koyama Yuko , Kamel Walied , Ueki Arisa , Ishikawa Tomoki , Chiyoda Tatsuyuki , Osuka Satoru , Onishi Nobuyuki , Ikeda Hiroko , Kamei Junzo , Matsuo Koichi , Fukuchi Yumi , Nagai Toshihiro , Toguchida Junya , Toyama Yoshiaki , Muto Akihiro , Saya Hideyuki
Published: April 2023

Supplementary Figure S3: (A) Immunoblot analysis of p-Akt and Akt expression in AXT cells with the supplement of Akt inhibitor IV or X. Cell viability after the treatment of Akt inhibitors. (B) Phosphorylation status of IGF1R in AXT cells.