bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphological Instability of Lithium Electrodeposition Induced by Elastic Stress-Driven Diffusion
Authors: Hebert Kurt R.
Published: May 2023

Lithium metal negative electrodes for liquid cells have high theoretical capacity, but suffer from unstable metal interfaces during charging. Here a model for morphology evolution during plating is presented that focuses on the interface instability during plating at low to moderate current density. It is proposed that the instability is caused by stress due to excess Li atoms incorporated in the metal during electrodeposition. The resulting stress gradients drive diffusion along the lithium surface that amplify surface roughness. The instabilty is modeled by extending the Asaro-Tiller-Grinfel’d diffusional instability for stressed surfaces of elastic solids to interfaces between elastic layers, namely that between lithium metal and the solid-electrolyte interphase (SEI). The assumption of elastic deformation is valid for lithium deposits less than about 1 μm thick. Linear stability analysis revealed that the model predicts the correct scaling between instability length scale and stress: for elastic stress of order 1 MPa as found experimentally, the spacing between interface protrusions is a few μm, similar to typical distances between whiskers on deposit surfaces. The model suggests that the instability can be suppressed by use of elastically stiff current collector substrates.
Efficacy of Spinal Cord Stimulation for Failed Back Surgery Syndrome in Elderly Patients: A Retrospective Study
Authors: Higashiyama Naoki , Tamura Shinya , Sugawara Taku
Published: May 2023

Objectives. Failed back surgery syndrome (FBSS) refers to a condition where symptoms such as low back pain, leg pain, and numbness persist or recur after lumbar surgery; it has been reported to occur in 10%–40% of patients who have undergone lumbar surgery. Spinal cord stimulation (SCS) has been reported useful for low back and leg pain due to FBSS. In this study, we studied the efficacy and safety of SCS for FBSS in older adults. Methods. Among FBSS patients who underwent an SCS trial between November 2017 and December 2020, those with at least 50% pain reduction during the trial phase who requested spinal cord stimulator implantation underwent implantation of a stimulator under local anesthesia. The patients were divided into two groups: patients aged <75 years (<75-year-old group) and patients aged ≥75 years (≥75-year-old group). The male/female ratio, symptom duration, operative duration, visual analog scale (VAS) scores before and after one year of surgery, responder rate (RR), complications one year after surgery, and stimulator removal rate were analyzed. Results. There were 27 cases in the <75-year-old group and 46 in the ≥75-year-old group, with no significant differences in male/female ratio, duration of pain, or operative time between the two groups. VAS scores for low back pain, leg pain, and overall pain one year after surgery were improved significantly from respective preoperative scores in both groups

P
<
0.001

. There were no significant differences in low back pain VAS, leg pain VAS, overall pain VAS, RR, complications one year after surgery, or stimulator removal rate between the two groups. Conclusion. SCS reduced pain effectively in both <75-year-old and ≥75-year-old groups with no differences in complications. Therefore, spinal cord stimulator implantation was considered a viable option for FBSS treatment in older adults because it can be performed under local anesthesia and is associated with a low incidence of complications.
Peripheral Multiple Cytokine Profiles Identified CD39 as a Novel Biomarker for Diagnosis and Reflecting Disease Severity in Allergic Rhinitis Patients
Authors: Jiang Yuanwei , Hu Weiqun , Cai Zhifu , Lin Chaofan , Ye Shengnan
Published: May 2023

Background. Allergic rhinitis (AR) is a common clinical problem, and immune cells and cytokines were proven to be pivotal in its pathogenesis. Our aim is to measure the peripheral concentrations of multiple cytokines in AR patients and identify novel biomarkers for diagnosis and disease severity. Methods. Peripheral blood samples were collected from 50 AR patients, including 25 mild AR (MAR) patients and 25 moderate-severe AR patients (MSAR), and 22 healthy controls (HCs), and multiple cytokine profiling was outlined by Luminex assay. Cytokine levels were compared among the three groups, and their correlations with disease severity were evaluated. The candidate cytokines were further verified by enzyme-linked immunosorbent assay (ELISA) in a validation cohort. Results. Multiple cytokine profiling revealed that CD39 and interferon (IFN)-γ levels were reduced, and interleukin (IL)-13, IL-5, IL-33, and thymic stromal lymphopoietin (TSLP) levels were elevated in the AR group than the HC group (

P
<
0.05

). Receiver operating characteristic (ROC) curves presented that serum CD39 and IL-33 exhibited strong diagnostic abilities, and serum CD39 and IL-10 presented capacities in distinguishing disease severity (

A
U
C
>
0.8

,

P
<
0.05

). Moreover, CD39 concentrations were decreased, and IL-10, IL-5, and TSLP concentrations were enhanced in the MSAR group more than in the MAR group. Correlation analysis results showed that serum CD39, IL-5, and TSLP levels were associated with total nasal symptom score (TNSS) and visual analogue score (VAS) (

P
<
0.05

). Further data in the validation cohort suggested that serum CD39 levels were reduced, and IL-5 and TSLP levels were increased in AR patients, especially in MSAR patients (

P
<
0.05

). ROC results revealed potential values of serum CD39 in diagnosis and disease severity evaluation in AR patients (

P
<
0.05

). Conclusion. This study highlighted that peripheral multiple cytokine profiles were significantly varied in AR patients and associated with disease severity. The results in discover–validation cohorts implied that serum CD39 might serve as a novel biomarker for diagnosing AR and reflecting its disease severity.
Model-Based Leakage Estimation and Remaining Useful Life Prediction of Control Gas Cylinder
Authors: Zhang Zhenzhen , Chen Hui , Qi Chao , Liu Yazhou
Published: May 2023

The high-pressure gas cylinder is the pressure source for liquid propellant engine valve control. Leakage is a significant cause of pressure loss in gas cylinders, leading to engine control failure and serious flight accidents. In this paper, a model-based approach to estimate the leakage area and remaining useful life (RUL) of gas cylinders is proposed. To estimate the leakage area, a state space representation of the cylinder system is developed based on the nonlinear model derived from momentum, energy, and continuity equations. Leakage is defined as a system state, and an extended Kalman filter (EKF) as a state observer is implemented to estimate the leakage area. Internal pressure measurements of the gas cylinder are required as output parameters in the estimation process. Then, the estimated states are fed into the nonlinear model to iteratively calculate the RUL of the cylinder. To evaluate the effectiveness of the proposed method, scaling leakage test data, computational fluid dynamics (CFD) simulation results, and liquid rocket engine (LREs) hot test data are used. Calibration results have proved the validity and universality of the method, with the mean absolute error (MAE) for the remaining 80% useful life prediction results being less than 0.02, 0.04, and 1.10. This study can provide technical support for fault tolerance control and orbital replanning in case of control gas cylinder leaks.
Numerical Solutions of Time-Fractional Whitham–Broer–Kaup Equations via Sumudu Decomposition Method
Authors: Ahmed Shams A. , Elbadri Mohamed , Hassan Abdelgabar Adam , Hdidi Walid
Published: May 2023

In this paper, the coupled system of Whitham–Broer–Kaup equations of the Caputo fractional derivative (CFD) is studied using the Sumudu decomposition method (SDM). Using different dispersion relations, these equations are needed to describe the properties of waves in shallow water. The current investigation for the future scheme includes convergence and error analysis. We use two examples to demonstrate the leverage and effectiveness of the proposed scheme, and the error analysis is discussed to ensure its accuracy. The numerical simulation is carried out to ensure the accuracy of the future technique. The obtained numerical and graphical results are presented, and the proposed scheme is computationally very accurate and simple to study and solve fractionally coupled nonlinear complex phenomena encountered in science and technology.
Does Genetic Background of Rainbow Trout Impact Growth and Feed Utilisation following Fishmeal Substitution by Partly Defatted Insect Meal (Hermetia illucens) or Microalgae Powder (Arthrospira platensis)?
Authors: Dietz Carsten , Wessels Stephan , Sünder Angela , Sharifi Reza , Gährken Jakob , Liebert Frank
Published: May 2023

A growth trial was carried out to evaluate differences in feed utilisation and growth performance in response to substitution of fishmeal (FM) by either partly defatted insect meal or microalgae powder in different strains of rainbow trout. Three iso-nitrogenous and iso-energetic diets were fed to 495 juvenile rainbow trout with initial weight of 150 ± 37 g. Whereas, the control diet included 20% FM, the two experimental diets were free of FM. Instead of that, an equal amount of spray-dried Spirulina powder (SP) or partly defatted Hermetia meal (HM) was applied as alternative protein source. Feed utilisation and growth response were investigated in a commercial breed (TL) and three local strains (HK3, HK7, and HK8) over a period of 56 days using three replicates per diet. Diets were fed relative to fish body weight throughout at a constant rate of 1.0%. Although growth was comparable among diets, growth and feed utilisation differed between breeds. The strain TL tended to express the highest specific growth rate, however, associated with lower feed conversion. Protein utilisation was superior in local strains irrespective of diet, most pronounced between strains HK7 and TL. Due to large differences in initial body weights, compensatory growth might have affected the study’s outcome. Both alternative protein sources showed to be adequate to fully replace FM in diets for rainbow trout. Improved adaption to diets including high levels of HM or SP might be achieved by selective breeding.
Interleukin-15 and Tumor Necrosis Factor-α in Iraqi Patients with Alopecia Areata
Authors: Kamil Zainab A. , Abdullah Galawish A. , Zalzala Haider Hashim
Published: May 2023

Background. Alopecia areata (AA) is a common form of noncicatricial hair loss of unknown cause, affecting 0.1-0.2% of the general population. Most evidence supports the hypothesis that it is disease of the hair follicle of autoimmune nature mediated by T-cells, with important cytokine role. Objective of the Study. The objective of this study is to study the association and changes in serum levels of interleukin-15 (IL-15) and tumor necrosis factor-α (TNF-α) in patients with AA in relation to the type, activity, and disease duration. Patients and Methods. Thirty-eight patients with AA and 22 individuals without the disease as controls were enrolled in this case-controlled study conducted in the Department of Dermatology in the Al-Kindy Teaching Hospital and Baghdad Medical City, Iraq, during a period from the 1st of April 2021 to the 1st of December 2021. Serum concentrations of IL-15 and TNF-α assessed using the enzyme-linked immunosorbent assay. Results. The mean serum concentration values for IL-15 and TNF-α were higher significantly in patients with AA than in controls (2.35 versus 0.35 pg/mL and 50.11 versus 20.92 pg/mL, respectively). IL-15 and TNF-α showed no statistically significant differences in level in terms of the type, duration, and activity of the disease, but TNF-α significantly higher in those with totalis-type than in other types. Conclusion. Both IL-15 and TNF-α are markers for alopecia areata. The level for these biomarkers was not affected by duration or disease activity, but it was affected by the type of disease, as the concentrations of IL-15 and TNF-α were higher in patient with Alopecia totalis than in other types of Alopecia.
Spatiotemporal Drivers of the African Swine Fever Epidemic in Lao PDR
Authors: Hui Ka Yi , Matsumoto Nina , Siengsanan-Lamont Jarunee , Young James R. , Khounsy Syseng , Douangneun Bounloum , Thepagna Watthana , Phommachanh Phouvong , Blacksell Stuart D. , Ward Michael P.
Published: May 2023

African swine fever (ASF) is a devastating transboundary disease of swine. Following the first report of ASF in China in August 2018, ASF spread through South-East Asian nations in 2019. Without control and containment measures, ASF can decimate smallholder pig holdings and disrupt value chains. This study aimed to describe the spatiotemporal spread of the 2019 Lao PDR ASF epidemic in domestic pigs, identify environmental (protected areas and forests), production (pig ownership), transportation (roads), and social (poverty and ethnicity) risk factors, and recommend measures that could reduce ASF spread. A retrospective spatiotemporal study was conducted at the village level. Information on the date that ASF was first reported from each case location was collected, and the outcome variable of interest “epidemic day” was created. Risk factor information from different sources was extracted for each case location. The association or correlation between epidemic day and risk factors for the spread of ASF was investigated using Kruskal–Wallis tests and Spearman rank correlation statistics. The epidemic started on June 16 and lasted for 190 days, displaying a right-skewed epidemic curve. The directional distribution was rotated approximately 305°, from Southeast to Northwest Laos. Significant risk factors for ASF associated with epidemic day were location in terms of distance from the closest protected natural area

P
=
0.020

, pig ownership

P
=
0.005

, road networks

P
=
0.003

, and poverty indices

P

<

0.001

. Cases were reported earlier in this epidemic at locations that were closer to protected natural areas, of higher pig ownership, more connected via the national road network, and which experienced elevated poverty. The spatiotemporal pattern described suggests that ASF was introduced via infected pigs from Vietnam. Based on study findings, recommendations for smallholder pig production in Southeast Asia include improving knowledge of swine value chains to inform disease risk and control, monitoring pig transportation, implementing stricter biosecurity measures on the domestic pig population, and providing biosecurity support and education to smallholder pig farmers in poverty.
Pancancer Analysis Revealed the Value of RAC2 in Immunotherapy and Cancer Stem Cell
Authors: Liu Ranran , Li Tianyu , Zhang Guohong , Jia Yejuan , Liu Jingxuan , Pan Lijia , Li Yunfeng , Jia Chunsheng
Published: May 2023

Objective. To investigate the oncogenic effect and clinical significance of RAC2 in pancarcinoma from the perspective of tumor immunity and cancer stem cell. Methods. After in-depth mining of TCGA, GEO, UCSC, and other databases, basic information of the RAC2 gene and its expression in tumor tissues as well as the relationship between RAC2 and tumor were analyzed based on survival, mutation, immune microenvironment, tumor stemness, and enrichment analysis on related pathways. Results. RAC2 mRNA expression was increased in most tumor tissues and was associated with their prognosis. Compared to normal tissues, the RAC2 mutation rate was higher in patients with skin melanoma, uterine sarcoma, and endometrial cancer. RAC2 had a strong relation with immune cell infiltration, immunomodulators, immunotherapy markers, cancer stem cell of THYM, and immune-related pathways. Conclusions. This study explored the potential importance of RAC2 in the prognosis, immunotherapy, and cancer stem cell of 33 cancers, laying the foundation for mechanistic experiments and its future application in clinical practice. However, the results using bioinformatics methods could be affected by the differences in patients across databases. Thus, the present results were preliminary and required further experimental validation.
Methane Adsorption in Anthracite Coal under Different Pressures and Temperatures—A Study Combining Isothermal Adsorption and Molecular Simulation
Authors: Jing Tieya , Zhang Jian , Zhu Mingyu , Zhao Wentao , Zhou Juan , Yin Yulong
Published: May 2023

In situ gas content is an important parameter associating coalbed methane, while the influence of pressure and temperature on methane adsorption and desorption still needs to be revealed. In this study, the molecular structure and methane adsorption capacity of anthracite coal collected from Diandong Coalfield (China) were studied based on 13C nuclear magnetic resonance (13C NMR), Fourier transform infrared spectroscopy (FT-IR), and methane isothermal adsorption experiment. The results show that the carbon skeleton of coal sample is mainly composed by aromatic carbon (72%), followed by aliphatic carbon structure (14.2%). Carbons connected to the oxygen atoms contribute 13.7% of the total carbons in coal molecule, and the oxygen atoms are mainly in the form of carbonyl. The 2-dimension structure and 3-dimension molecular structure of coal sample was also reconstructed. The average chemical formula of the coal molecule is C200H133O21N3. The experimental methane adsorption isothermal data of the coal sample under different temperatures shows that with increasing the temperature, the methane adsorption amount at each pressure decreases obviously. At 7 MPa and 20°C, the methane adsorption amount of the coal sample is 28.5 cm3/g. Comparably, at 100°C and 7 MPa, the methane adsorption amount is only 15.9 cm3/g, decreasing by 44%. In mesopores, temperature has stronger influence on methane adsorption under higher pressure than that of lower pressure. On the contrary, in micropores, temperature has weaker effects on methane adsorption at higher pressure than that at lower pressure. The results can be beneficial for understanding methane adsorption characteristics of deep coal.
Multipotential Surface Elastoplastic Constitutive Model and Its Application in the Analysis of the Phase II Cofferdam of the Three Gorges Project
Authors: Wen Yong , Yang Guanghua , Zhong Zhihui
Published: May 2023

Based on multipotential surface theory, an elastoplastic constitutive model is established in this paper. The required parameters of the proposed model are the same as those of the Duncan-Chang model, and the proposed model is no longer restricted by the generalized form of Hooke’s law. In addition, the proposed model uses a numerical method to fit the test curves to determine the required parameters. The calculation program of the proposed model is also developed by FLAC3D, and according to the comparison with the triaxial test results of gravel and the stress and deformation analysis of the phase II cofferdam of the Three Gorges Project, the rationality and superiority of the proposed model are verified.
Hepatocellular Carcinoma Surveillance among Individuals with Cirrhosis: Trends by Payer, Etiology, and Calendar Year, from a Statewide, Multi-Payer Dataset, 2010–2018
Authors: Hsu Christine D. , Henderson Louise M. , Jackson Bradford E. , Baggett Christopher D. , Funk Michele Jonsson , Olshan Andrew F. , Gupta Parul , Barritt A. Sidney , Sanoff Hanna K. , Wheeler Stephanie B. , Moon Andrew M. , Lund Jennifer L.
Published: May 2023

Background:

Hepatocellular carcinoma (HCC) surveillance is underutilized, with <25% of individuals with cirrhosis receiving surveillance exams as recommended. The epidemiology of cirrhosis and HCC in the United States has also shifted in recent years, but little is known about recent trends in surveillance utilization. We characterized patterns of HCC surveillance by payer, cirrhosis etiology, and calendar year in insured individuals with cirrhosis.

Methods:

We conducted a retrospective cohort study of individuals with cirrhosis using claims data from Medicare, Medicaid, and private insurance plans in North Carolina. We included individuals ≥ 18 years with a first occurrence of an ICD-9/10 code for cirrhosis between January 1, 2010, and June 30, 2018. The outcome was HCC surveillance by abdominal ultrasound, CT, or MRI. We estimated 1- and 2-year cumulative incidences for HCC surveillance and assessed longitudinal adherence to surveillance by computing the proportion of time covered (PTC).

Results:

Among 46,052 individuals, 71% were enrolled through Medicare, 15% through Medicaid, and 14% through private insurance. The overall 1-year cumulative incidence of HCC surveillance was 49% and the 2-year cumulative incidence was 55%. For those with an initial screen in the first 6 months of their cirrhosis diagnosis, the median 2-year PTC was 67% (Q1, 38%; Q3, 100%).

Conclusions:

HCC surveillance initiation after cirrhosis diagnosis remains low, though it has improved slightly over time, particularly among individuals with Medicaid.

Impact:

This study provides insight into recent trends in HCC surveillance and highlights areas to target for future interventions, particularly among patients with nonviral etiologies.
Supplemental Figure S2 from Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma
Authors: Kelly William , Diaz Duque Adolfo Enrique , Michalek Joel , Konkel Brandon , Caflisch Laura , Chen Yidong , Pathuri Sarath Chand , Madhusudanannair-Kunnuparampil Vinu , Floyd John , Brenner Andrew
Published: May 2023

Progression Free Survival by Exosome (50-120nm, N=24) Concentration Relative Change (< -0.01, >-0.01): p=0.19 [<-0.01: median=6.3, 95% CI 4.0 to 12.0, >-0.01: median=4.4 95% CI 2.3, 5.9]
Supplementary Data 1 from Adjuvant Nivolumab versus Ipilimumab in Resected Stage III/IV Melanoma: 5-Year Efficacy and Biomarker Results from CheckMate 238
Authors: Larkin James , Del Vecchio Michele , Mandalá Mario , Gogas Helen , Arance Fernandez Ana M. , Dalle Stéphane , Cowey Charles Lance , Schenker Michael , Grob Jean-Jacques , Chiarion-Sileni Vanna , Marquez-Rodas Ivan , Butler Marcus O. , Di Giacomo Anna Maria , Middleton Mark R. , Lutzky Jose , de la Cruz-Merino Luis , Arenberger Petr , Atkinson Victoria , Hill Andrew G. , Fecher Leslie A. , Millward Michael , Nathan Paul D. , Khushalani Nikhil I. , Queirolo Paola , Ritchings Corey , Lobo Maurice , Askelson Margarita , Tang Hao , Dolfi Sonia , Ascierto Paolo A. , Weber Jeffrey
Published: May 2023

DATA SUPPLEMENT Adjuvant Nivolumab Versus Ipilimumab in Resected Stage III/IV Melanoma: 5-Year Efficacy and Biomarker Results From CheckMate 238
Supplementary Video S2B from First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Authors: Duan Xiaojiang , Xia Lei , Zhang Zhuochen , Ren Yanan , Pomper Martin G. , Rowe Steven P. , Li Xuesong , Li Nan , Zhang Ning , Zhu Hua , Yang Zhi , Sheng Xinan , Yang Xing
Published: May 2023

40 min full dynamic Total-body PET imaging of Patient 8
Supplementary Table S2 from First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Authors: Duan Xiaojiang , Xia Lei , Zhang Zhuochen , Ren Yanan , Pomper Martin G. , Rowe Steven P. , Li Xuesong , Li Nan , Zhang Ning , Zhu Hua , Yang Zhi , Sheng Xinan , Yang Xing
Published: May 2023

Information of healthy subjects and urothelial carcinoma patients enrolled in PET/CT imaging studies using 68Ga-N188 and 18F-FDG
Supplementary File 1 from PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in Patients with Myelofibrosis
Authors: Moyo Tamara K. , Kishtagari Ashwin , Villaume Matthew T. , McMahon Brandon , Mohan Sanjay R. , Stopczynski Tess , Chen Sheau-Chiann , Fan Run , Huo Yuankai , Moon Hyeonsoo , Tang Yucheng , Bejan Cosmin A. , Childress Merrida , Anderson Ingrid , Rawling Kyle , Simons Rhea M. , Moncrief Ashley , Caza Rebekah , Dugger Laura , Collins Aunshka , Dudley Channing V. , Ferrell P. Brent , Byrne Michael , Strickland Stephen A. , Ayers Gregory D. , Landman Bennett A. , Mason Emily F. , Mesa Ruben A. , Palmer Jeanne M. , Michaelis Laura C. , Savona Michael R.
Published: May 2023

Supplemental Tables S1-S9 Supplemental Figures S1-S2
Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity
Authors: Sukeda Nao , Fujigaki Hidetsugu , Ando Tatsuya , Ando Honomi , Yamamoto Yasuko , Saito Kuniaki
Published: May 2023

Cisplatin is a chemotherapeutic agent used to treat many types of malignant tumors. However, irrespective of its potent anticancer properties and efficacy, nephrotoxicity is the dose-limiting factor of cisplatin treatment. Cisplatin infiltrates renal tubular cells in the kidneys and is metabolized by cysteine conjugate-beta lyase 1 (CCBL1) to form highly reactive thiol-cisplatin; this may mediate cisplatin's nephrotoxicity. Therefore, CCBL1 inhibition may prevent cisplatin-induced nephrotoxicity. Using a high-throughput screening assay, we identified 2′,4′,6′-trihydroxyacetophenone (THA) as an inhibitor of CCBL1. THA inhibited human CCBL1 β-elimination activity in a concentration-dependent manner. We further investigated the preventive effect of THA on cisplatin-induced nephrotoxicity. THA attenuated the effect of cisplatin on the viability of confluent renal tubular cells (LLC-PK1 cells) but had no effect on cisplatin-induced reduction of proliferation in the tumor cell lines (LLC and MDA-MB-231). THA pretreatment significantly attenuated cisplatin-induced increases in blood urea nitrogen, creatinine, cell damage score, and apoptosis of renal tubular cells in mice in a dose-dependent manner. Furthermore, THA pretreatment attenuated cisplatin-induced nephrotoxicity without compromising its antitumor activities in mice bearing subcutaneous syngeneic LLC tumors. THA could help prevent cisplatin-induced nephrotoxicity and may provide a new strategy for cisplatin-inclusive cancer treatments.
Figure S6 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

Single cell analyses of cell progeny of the alternate stem cells mobilized by the western diet to maintain the mucosa.
Figure S2 from Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Authors: Choi Jiahn , Zhang Xusheng , Li Wenge , Houston Michele , Peregrina Karina , Dubin Robert , Ye Kenny , Augenlicht Leonard
Published: May 2023

The western diet elevates and suppresses multiple pathways by 3 months, most persisting to 12 months, and reversible by switching to control diet.
SupplementaryFigure 6 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax
Authors: Waclawiczek Alexander , Leppä Aino-Maija , Renders Simon , Stumpf Karolin , Reyneri Cecilia , Betz Barbara , Janssen Maike , Shahswar Rabia , Donato Elisa , Karpova Darja , Thiel Vera , Unglaub Julia M. , Grabowski Susanna , Gryzik Stefanie , Vierbaum Lisa , Schlenk Richard F. , Röllig Christoph , Hundemer Michael , Pabst Caroline , Heuser Michael , Raffel Simon , Müller-Tidow Carsten , Sauer Tim , Trumpp Andreas
Published: May 2023

Comparison of MAC-Score and BH-3 profiling based response prediction
Supplementary Figure 3 from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax
Authors: Waclawiczek Alexander , Leppä Aino-Maija , Renders Simon , Stumpf Karolin , Reyneri Cecilia , Betz Barbara , Janssen Maike , Shahswar Rabia , Donato Elisa , Karpova Darja , Thiel Vera , Unglaub Julia M. , Grabowski Susanna , Gryzik Stefanie , Vierbaum Lisa , Schlenk Richard F. , Röllig Christoph , Hundemer Michael , Pabst Caroline , Heuser Michael , Raffel Simon , Müller-Tidow Carsten , Sauer Tim , Trumpp Andreas
Published: May 2023

Bcl-2 family gene expression in LSCs predicts in vitro response to HMA/VEN
TABLE 1 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

Patient population
FIGURE 2 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

IHC analysis of CD8 in preinfusion and postinfusion tumor tissue. Three subjects had preinfusion and postinfusion tumor tissue available for analysis; postinfusion tumor tissue demonstrated an increase in cytoxic CD8+ cells in all 3 subjects.
FIGURE 1 from Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma
Authors: Shah Payal D. , Huang Alexander C. , Xu Xiaowei , Orlowski Robert , Amaravadi Ravi K. , Schuchter Lynn M. , Zhang Paul , Tchou Julia , Matlawski Tina , Cervini Amanda , Shea Joanne , Gilmore Joan , Lledo Lester , Dengel Karen , Marshall Amy , Wherry E. John , Linette Gerald P. , Brennan Andrea , Gonzalez Vanessa , Kulikovskaya Irina , Lacey Simon F. , Plesa Gabriela , June Carl H. , Vonderheide Robert H. , Mitchell Tara C.
Published: May 2023

Study procedures. Participant study procedures including cell collection/manufacturing timeline as well as infusion schedule from eligibility confirmation onward.
Supplementary Table 3 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

List of differentially methylated gene promoters (paired analysis of 5 selected tumors).
Figure S9 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Clustering of somatic copy number alterations profiles.
Figure S16 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Complete clonal evolution of P15 tumor.
Figure S15 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Complete clonal evolution of P12 tumor.
Figure S13 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: May 2023

Complete clonal evolution of P01 tumor.
Figure S2 from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Authors: Terzo Esteban , Apte Shruti A , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: May 2023

Results for pSILAC Mass Spec study demonstrating ZKN-157 inhibits translation of a subset of proteins
Data from A novel class of Ribosome Modulating Agents (RMAs) exploits cancer ribosome heterogeneity to selectively target the CMS2 subtype of colorectal cancer
Authors: Terzo Esteban , Apte Shruti A , Padhye Simran , Rashed Saleh , Austin Wesley , Caponegro Michael , Reddy Anupama , Shi Shuhao , Wang Christy , Clark Roger B , Sidransky David , Modur Vijay , Badarinarayana Vasudeo
Published: May 2023

Abstract
Ribosomes in cancer cells accumulate numerous patient-specific structural and functional modifications that facilitate tumor progression by modifying protein translation. We have taken a unique synthetic chemistry approach to generate novel macrolides, Ribosome Modulating Agents (RMAs), that are proposed to act distal to catalytic sites and exploit cancer ribosome heterogeneity. The RMA ZKN-157 shows two levels of selectivity: 1) selective translation inhibition of a subset of proteins enriched for components of the ribosome and protein translation machinery that are upregulated by MYC; and 2) selective inhibition of proliferation of a subset of colorectal cancer (CRC) cell lines. Mechanistically, the selective ribosome targeting in sensitive cells triggered cell cycle arrest and apoptosis. Consequently, in CRC, sensitivity to ZKN-157 in cell lines and patient-derived organoids was restricted to the Consensus Molecular Subtype 2 (CMS2) subtype that is distinguished by high MYC and WNT pathway activity. ZKN-157 showed efficacy as single agent and, the potency and efficacy of ZKN-157 synergized with clinically approved DNA intercalating agents which have previously been shown to inhibit ribogenesis as well. ZKN-157 thus represents a new class of ribosome modulators that display cancer selectivity through specific ribosome inhibition in the CMS2 subtype of CRC potentially targeting MYC-driven addiction to high protein translation.
Gestão, política, economia e ética na educação
Authors:   Universidade de São Paulo. Faculdade de Educação, Paro Vitor Henrique
Published: May 2023

Com esta coletânea de textos de Vitor Henrique Paro – Gestão, política, economia e ética na educação –, publicada por ocasião da outorga do título de Professor Emérito da Universidade de São Paulo, o leitor entrará em contato com suas ideias, pensamentos, estudos e palavras. É o seu vigésimo livro, o primeiro inteiramente em formato digital, uma antologia de onze textos publicados em revistas acadêmicas, livros, eventos acadêmicos e jornais de grande circulação.
A liberdade é uma vertigem: prostituição e lesbianidade na literatura do grande século XIX
Authors: Santos Claudiana Gois dos
Published: May 2023

Um dos traços presentes em boa parte das prostitutas personagens de literatura é o impacto da tentativa de controle dos corpos realizada por diversas esferas de poder. No presente artigo, pretende-se observar a emergência dessas personagens na literatura do século XIX a partir das definições de prostituição e suas variações ao longo do tempo, analisar como tais definições impactaram a criação de personagens literárias e quais os diálogos que a literatura brasileira estabeleceu com algumas das narrativas francesas que moldaram imaginário da prostituição do século XIX. Além disso, ao especular tais variações, discutiremos as mudanças perceptíveis ao longo daquele século na formulação destas personagens na literatura.
As alegorias de "Levedando a ilha..."
Authors: Lima Kelly Mendes , Corvacho Suely , Silva Thomaz  Machado
Published: May 2023

O artigo analisa o conto “Levedando a ilha…” (1962), de Maria Margarida Mascarenhas, na perspectiva metodológica do Círculo de Bakhtin, defendendo a ideia de existirem alegorias relacionadas ao contexto caboverdiano. Para análise, adotamos a definição de alegoria proposta por Lausberg, metáfora que consiste na substituição do pensamento em causa, por outro, ligando-os uma relação de semelhança. Como resultado, apresentamos alguns elementos – autoria, espaço, composição da heroína e momentos do enredo - que podem ser interpretados como analogias da geografia, da formação da sociedade e da luta pela independência do arquipélago.
Arsenals of Knowledge: Reconstructing the Contents and Purpose of the Lost Jesuit Libraries of Northern Mexico
Authors: Manrique Figueroa César
Published: May 2023

This article examines several libraries assembled by the Society of Jesus in their college and missions in Northern Mexico (in the present-day Mexican State of Chihuahua), where Jesuits have been a constant presence from the seventeenth century, interrupted only temporarily by the Society’s suppression. All their bibliographic collections were transferred, dispersed, or looted after the general expulsion of 1767. Archival materials preserved in repositories such as the Archivo General de la Nación in Mexico City, however, enable a reconstruction of these libraries. This essay argues that these collections constituted a sort of “cultural oasis” (Michael Mathes). They provided arsenals of knowledge for missionaries in distant places with harsh living conditions and show the strong and lasting bond between Jesuits and print culture even in the most remote and adverse of conditions.
Colletotrichum menezesiae sp. nov.: a novel species causing anthracnose on chayote in Brazil
Authors: DOS SANTOS VIEIRA WILLIE ANDERSON , ALMEIDA DA COSTA CHRISTIANE , PAZ SARAIVA CÂMARA MARCOS , MICHEREFF SAMI JORGE , REIS AILTON
Published: May 2023

A new pathogenic Colletotrichum species was isolated from chayote (Sicyos edulis) leaves and fruit presenting typical anthracnose symptoms from fields in Ibirité (Minas Gerais state) and Tijucas (Santa Catarina state), Brazil. The species Colletotrichum menezesiae sp. nov. is described and illustrated. Multilocus phylogenetic analyses based on combined ACT, GAPDH, nrITS and TUB2 partial sequences revealed that Colletotrichum isolates from chayote form a distinct clade within the C. orbiculare species complex. This clade does not contain the ex-type of any species previously described and is also recognized as an independent lineage according to the GCPSR criteria.
Construction and Efficacy of a Novel Treatment Against Acute Leukemia by Using Mesoporous Silica Nanoparticles and Arsenic
Authors: Zhang Sufang , Wang Qianru , Zhang Bingbing , Wen Hui , Ma Yan’e
Published: May 2023

This study aimed to use mesoporous silica nanoparticles (MNPs) as the carrier material, and connect non-toxic and non-immunogenic polyethylene glycol (PEG) and arsenic trioxide (AO) as a novel treatment of acute leukemia in vitro. Silica was synthesized by co-precipitationmethod.
Based on this, a redox-responsive carrier (MNPs-PEG) was synthesized. The drug loading of AO-loaded modified silica (MNPs-AO) and MNPs-PEG/AO were verified by thermogravimetric analyzer. The dialysis bag method was used to investigate the in vitro drug release characteristics of the
drug delivery system under different pH conditions. The MTT method was used to investigate the toxicity of the carrier and drug delivery system to human normal hemopoietic cells or human acute leukemia cells. Compared with normal cells, acute leukemia cell line was more sensitive to the toxicity
of the carrier, and the cell viability of the MNPs-PEG group is greater than that of the MNPs group, indicating that PEG modification can further reduce the cell viability of the carrier. In addition, MTT results showed that the effect of MNPs-PEG/AO group on inhibiting the growth of acute
leukemia cells was significantly higher than that of other groups. Overall, this nano-drug delivery system has a good application prospect in tumor therapy as a tumor microenvironment responsive carrier in acute leukemia.
Self-Ligation-Free Next Generation Sequencing Adapters Applied to Methylation Assay
Authors: Qi Peng , Zeng Ya-ling , Ye Xu , Li Ya-mei , Wang Feng-jiao , Pu Wang-yang , Zhang Rong , Li Min , Xiao Li , Huang Gang , Pierre Sirois , Chuan Jun , Luo Jingjing , Liao Duan-fang , Wen Hongyan , Li Kai
Published: May 2023

In developing a bisulfite-free methylation assay with the use of restriction enzymes, self-ligation of next generation sequencing adapters (NGS-adapter) is a technological bottleneck to be overcome. In the experiments of this study, a variety of strategies designed to limit or abolish
adapter’s self-ligation has been tested. Experimental data have showed that the three strategies tested can either substantially decrease or completely abolish the self-ligation of NGS-adapters. Minimization or elimination of NGS-adapter’s self-ligation is of importance in increasing
the sensitivity, efficiency, and reproducibility of enzyme-mediated methylation assay. The strategies reported in the present study may find applications in some other nanotechnologies. In combination with nanotechnologies, either drop-digit PCR or microarray-based sequencing, the methylation-dependent
endonuclease mediated methylation assays will facilitate applications of methylation analysis in both fundamental research and clinical epigenetic studies, particularly in early diagnosis of cancer.
Construction of A Novel Prognostic Model with Molecular Targets for Hepatocellular Carcinoma Based on Bioinformatics Applications
Authors: Ye Zhifeng , Wang Lu
Published: May 2023

We aimed to analyze the differentially expressed genes associated with hepatocellular carcinoma (HCC) by bioinformatics method and to identify potential molecular targets for immunotherapy and molecular indicators for predicting HCC prognosis. Gene Expression Omnibus (GEO) was used
to download the hepatocellular carcinoma related microarray data. The R language’s Limma tool was used to identify the genes with differential expression. For differentially expressed genes, GO (Gene Ontology) enrichment analysis, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway
analysis, and protein–protein interaction analysis were carried out. PPI (protein–protein interaction) regulation network construction. In order to further evaluate HCC specific differentially expressed genes, HCC specific expression analysis was carried out at the same time by
merging with other tumour RNA-seq transcriptome data in the TCGA database. The relationship between immune-related LncRNA and independent risk factors was examined using univariate and multivariate Cox regression as well as Least absolute shrinkage and selection operator (LASSO) analysis.
The proportional Hazards model (COX model) was utilized to model the chosen important genes and predict the prognosis. We obtained important genes through additional screening, and the GSE6764 validation set discovered that the expression of these genes decreased with increasing tumor stage
(P < 0.05). The prognosis analysis of the gene model revealed that the high-risk group had a dismal outcome. COX modelling was carried out for important genes. Meanwhile, the GSE76427 and GSE54236 validation sets validated the model’s survival analyses. By analyzing the gene
expression profile of HCC utilizing cuttingedge bioinformatics techniques including Cox Regression and LASSO analysis, we were able to screen out the important modules and essential genes, create a predictive model for HCC, and propose possible biomarkers for the prediction of HCC.
Security Flaws in Wireless Sensor Networks and Authentication Procedures for Internet of Things
Authors: Irshad Reyazur Rashid , Shaman Faisal , Mehdi Mohammed , Islam Asharul , Rasool Mohammad Ashiquee , Khan Imran Mohd , Alattab Ahmed Abdu , Alnfrawy Ehab Tawfeek , Fatima Kainat
Published: May 2023

The Internet of Things (IoT) refers to a new paradigm in which everyday products and tools are networked and shared amongst people and other devices. As a result of the benefits it provides to homeowners in terms of convenience and efficiency, IoT technology is expected to become a
critical component in the creation of smart homes. Integrity, authenticity, and confidentiality of the data sensed, gathered, and transferred by IoT items in smart homes provide additional security and privacy problems brought on by the application of the IoT model. Because of these issues,
smart homes based on the Internet of Things are not secure and are susceptible to a wide variety of security threats. A comprehensive risk assessment should precede any security measures in order to identify and resolve any underlying concerns. Analytical representation based on assessing
security issues shows that the suggested method reduces throughputs by 5–17%, latency by 0–0.08, and time by 1–3% compared to the FBC approach and the EESCFD method.