bluuebunny/crossref_metadata_2025 huggingface dataset:
Attenuated Plasticity of Postsynaptic Kainate Receptors in Hippocampal CA3 Pyramidal Neurons
Authors: Ito Koichi , Contractor Anis , Swanson Geoffrey T.
Published: July 2004

Kainate receptor-mediated components of postsynaptic currents at hippocampal mossy fiber synapses have markedly slower kinetics than currents arising from AMPA receptors. Here, we demonstrate that other aspects of kainate and AMPA receptor function at this synapse are distinct; in particular, kainate receptor currents are less sensitive to short- and long-term increases in presynaptic strength. EPSCs arising predominantly from AMPA receptors exhibited well characterized paired-pulse facilitation, frequency facilitation, and NMDA receptor-independent long-term potentiation, whereas isolated kainate receptor synaptic currents (KA-EPSCs) exhibited attenuated facilitation and long-term potentiation. In addition, KA-EPSCs varied in their sensitivity to a low-affinity competitive antagonist, suggestive of a synaptic heterogeneity greater than that of EPSCs comprised predominantly of AMPA receptors. These data suggest that the proportional contribution of AMPA and kainate receptors to ensemble synaptic currents will vary depending on the firing frequency of mossy fiber afferents. These synaptic features may be a mechanism for limiting activation of kainate receptors at mossy fiber synapses, which has been shown to be involved in seizurogenic firing of the CA3 network.
The Influence of Sustained Selective Attention on Stimulus Selectivity in Macaque Visual Area MT
Authors: Wegener Detlef , Freiwald Winrich A. , Kreiter Andreas K.
Published: July 2004

Remarkable alterations of perception during long-lasting attentional processes have been described in several recent studies. Although these findings have gained much interest, almost nothing is known about the modulation of neuronal responses during sustained attention. Therefore, we investigated the effect of prolonged selective attention on neuronal feature selectivity. Awake macaque monkeys were trained to perform a motion-tracking task that required attending one of two simultaneously presented moving bars for up to 15 sec. Extracellular recordings were obtained from neurons in macaque motion-sensitive middle temporal visual area (MT/V5). Under conditions of attention, we found high and constant direction selectivity over time. This was expressed by a strong and persistent response contrast between presentations of preferred and nonpreferred stimuli in successive motion cycles. With attention directed to another moving bar, neuronal responses to the behaviorally irrelevant stimulus became continuously less specific for the direction of motion. In particular, increasingly higher firing rates for motion in null direction caused a strong reduction of direction selectivity, which further increased with enhanced proximity between target and distracter bar. A passive condition experiment revealed that this reduction occurred only when motion remained the behaviorally relevant feature but disappeared when attention was withdrawn from this feature domain. Thus, sustained attention seems to stabilize direction selectivity of neurons in area MT against a time and competition-dependent degradation, whereas nonattended objects suffer from a reduced neuronal representation.
Synaptotagmin I Synchronizes Transmitter Release in Mouse Hippocampal Neurons
Authors: Nishiki Tei-ichi , Augustine George J.
Published: July 2004

We have asked whether loss of the Ca2+sensor protein synaptotagmin I influences the total amount of neurotransmitter released after a presynaptic action potential. Hippocampal neurons from synaptotagmin I knock-out mice had a greatly reduced fast synchronous component of glutamate release, as reported previously. However, the amount of glutamate released during the slow asynchronous component increased in these knock-out neurons. As a result of these changes in the kinetics of release, there was no significant difference between wild-type and knock-out neurons in the total amount of transmitter released within 400 msec after a presynaptic stimulus. Fluorescence imaging experiments demonstrated that wild-type and knock-out neurons take up and release similar amounts of FM dye after depolarization, indicating normal amounts of synaptic vesicle trafficking in the knock-out neurons. These results indicate that synaptotagmin I knock-out neurons are fully capable of releasing neurotransmitter, with the increased slow component of release serving to compensate for loss of the fast component. Thus, synaptotagmin I synchronizes the rapid release of neurotransmitters after Ca2+entry into presynaptic terminals and also appears to suppress the slower, asynchronous form of transmitter release.
Erythropoietin and Erythropoietin Receptor: History, Structure, Interactions, and Intracellular Signal Transduction
Authors: Ghaffari Saghi , Constantinescu Stefan N.
Published: July 2004

Erythropoietin (Epo) is essential for formation of red blood cells. Recombinant Epo has been improving life of thousands of patients with anemia such as renal patients around the world. More recently, it has become clear that Epo may also regulate the behavior of other cell types such as neuronal cells, where Epo exerts an antiapoptotic effect. Understanding the modality of action of Epo in erythroid cells will help in characterizing the role of Epo in other cell types where Epo‐receptor (EpoR) is expressed.
Giant omphalocele and “prune belly” sequence as components of the Beckwith–Wiedemann syndrome
Authors: Sinico Martine , Touboul Claudine , Haddad Bassam , Encha‐Razavi Féréchté , Paniel Jean‐Bernard , Gicquel Christine , Gérard‐Blanluet Marion
Published: July 2004

We report a case of severe Beckwith–Wiedemann syndrome (BWS) in a fetus at 16 weeks of gestation. This presentation, incompatible with life, included a giant omphalocele and absence of abdominal wall musculature with extremely dilated bladder, as in the “prune belly” sequence. Adrenal cytomegaly pointed to BWS. Molecular analysis confirmed the diagnosis of BWS and showed an isolated demethylation of the KCNQ1OT1 gene. This report demonstrates that lethal fetal abdominal wall defects associated with adrenal cytomegaly are linked to epigenetic change of the 11p15 imprinted region. © 2004 Wiley‐Liss, Inc.
A de novo complex karyotype with two independent balanced translocations and a double inversion of chromosome 6 presenting with multiple congenital anomalies
Authors: Kline Antonie D. , Griffin Constance A. , Haddadin Mary H. , Chudoba Ilse , Morsberger Laura A. , Hawkins Anita L. , Amato R. Stephen , Munshi Gaurang , Cohen Maimon M.
Published: July 2004

We report a 4‐year‐old female with a de novo complex karyotype with multiple chromosomal rearrangements and a distinctive phenotype. Her medical history is significant for having been a twin born at 35 weeks gestation, breech presentation, with feeding problems and poor growth as an infant, gastroesophageal reflux disease, peripheral pulmonic stenosis, omphalocele, high myopia, and severe mental retardation. She is small for her age with microcephaly, posteriorly sloping forehead, shallow orbits, long palpebral fissures, prominent nose, wide mouth, absent uvula, kyphosis, brachydactyly, bridged palmar crease, and hypertonia. Peripheral blood lymphocytes revealed a karyotype of 46,XX,t(1;12)(p22.3;q21.3),inv(6)(p24q23),t(7;18)(q11.2;q21.2) in all cells. Parental karyotypes and that of her twin were normal. Spectral Karyotyping™ (SKY) and fluorescence in situ hybridization (FISH) with whole chromosome paints for chromosomes 1, 6, 7, 12, and 18 did not reveal additional rearrangements. Prometaphase G‐banding analysis suggested that the “inverted” chromosome 6 might contain a cryptic rearrangement. Although no deletion nor duplication was detected using metaphase comparative genomic hybridization (CGH), multicolor high resolution banding (mBAND) demonstrated a double inversion of chromosome 6, resulting in a final karyotype as above but including der(6)(pter → p23::q21 → q22.3::q21 → p23::q22.3 → qter). © 2004 Wiley‐Liss, Inc.
Renal defects and limb deficiencies in 197 infants: Is it possible to define the “acrorenal syndrome”?
Authors: Kroes Hester Y. , Olney Richard S. , Rosano Aldo , Liu Yecai , Castilla Eduardo E. , Cocchi Guido , De Vigan Catherine , Martínez‐Frías María L. , Mastroiacovo Pierpaolo , Merlob Paul , Mutchinick Osvaldo , Ritvanen Annukka , Stoll Claude , van Essen Anthonie J. , Cobben Jan Maarten , Cornel Martina C.
Published: July 2004

Dieker and Opitz in 1969 described the simultaneous occurrence of limb deficiencies (LDs) and renal anomalies (RAs) in three patients. Curran and Curran introduced in 1972 the term “acrorenal syndrome.” Since then, the term “acrorenal syndrome” is used occasionally, but a well‐circumscribed definition has never been established. On the other hand, the concept of an acrorenal polytopic developmental field defect was postulated by Opitz and others to explain the association between RAs and LDs. We undertook this study to investigate whether this acrorenal “syndrome” could be identified in a large group of cases with congenital RAs and a limb deficiency. Eleven birth defect registries that are part of the International Clearinghouse for Birth Defects Monitoring (i.e., registries of ICBDMS in Finland, France [Paris and Strasbourg], Israel, Italy [IPIMC and Emilia Romagna], Mexico, Northern Netherlands, South America, Spain, and the United States [Atlanta]) provided data on 815 infants who had a LD and at least one other major congenital anomaly. These 815 cases were ascertained among 5,163,958 births. We selected the 197 cases who had both a limb deficiency and a renal or urinary tract anomaly. In about 50% of these cases a diagnosis or a recognized phenotype was reported, with chromosomal aberrations and VACTERL being most frequent. In the group with no diagnosis or recognized phenotype (95 cases), we looked for (a) clustering of specific types of LDs and RAs, and (b) for clustering of associated anomalies, in order to find evidence for and be able to define better the term “acrorenal syndrome.” Our data suggest that an association exists between LDs and RAs, possibly explained by the concept of the acrorenal polytopic developmental field defect. However, our dataset does not yield evidence for the existence of one distinct “syndrome,” defined as a pattern of causally related multiple anomalies. Therefore, use of the term “acrorenal syndrome” should be avoided. © 2004 Wiley‐Liss, Inc.
Synthesis and Cytostatic Properties of Some 6H‐Indolo[2, 3‐b][1, 8]naphthyridine Derivatives
Authors: Mastalarz Henryk , Jasztold‐Howorko Ryszard , Rulko Felicja , Croisy Alain , Carrez Daniele
Published: July 2004

The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2‐chloro‐1, 8‐naphthyridines. The synthesized 6H‐indolo[2, 3‐b][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.
Prognosen bei Beobachtungsmethoden
Authors: Gudehus Gerd
Published: July 2004

Die Beobachtungsmethode nach Peck und diejenige der neuen DIN 1054 setzen übliche geotechnische Prognosen voraus. Die kurz vorgestellte Hypoplastizität ermöglicht Prognosen in einem weiteren Anwendungsbereich. Dies wird von Beispielen Pecks ausgehend konkretisiert und diskutiert. Dabei kommen eingeschränkte Duktilität und verzögerter Kriechbruch zur Sprache. Varianten der Beobachtungsmethode werden dargelegt, am Schluß auch eine mit Hypoplastizität.
Empfehlung Nr. 2 des Arbeitskreises “Geotechnik historischer Bauwerke und Naturdenkmäler” der DGGT: Baugrundbedingte Risse und Verformungen an historischen Bauwerken
Authors: Smoltczyk Ulrich
Published: July 2004

Der Arbeitskreis “Geotechnik historischer Bauwerke und Naturdenkmäler” der Deutschen Gesellschaft für Geotechnik e.V. erarbeitet Empfehlungen für das Vorgehen beim Auftreten von Schäden an historischen Bauwerken, die auf Effekte im Untergrund bzw. Gründungsbereich zurückzuführen sind.
RECP: A Reactor Designed to Test the Effect of a Catalyst on Soot Oxidation in a Diesel Particulate Filter
Authors: Nguyen Huu Nhon Y. , Brilhac J.‐F. , Petit C.
Published: July 2004

A new reactor designed to test soot combustion on a filter coated with an oxidation catalyst is described. It is designed to achieve screening investigations of catalysts in realistic conditions, i.e., close to those prevailing in a diesel particulate filter (DPF). In a DPF a soot layer is formed at the surface of a porous wall (filtration area) which may or may not be covered with a catalytic layer. In this new setup, the soot is deposited on a sample of a DPF which can be easily impregnated with oxidation catalysts. A model soot (commercial carbon black) is used for the investigation, and different procedures for the soot „deposit on the filter are tested.
Translation of MAT Kinetic Data to Model Industrial Catalytic Cracking Units
Authors: Maya‐Yescas R. , León‐Becerril E. , Salazar‐Sotelo D.
Published: July 2004

Bench‐ and laboratory‐scale reactors are required to infer kinetic data for catalytic cracking units. One of the most common methods is the microactivity test (MAT, ASTM D‐3902–92), that emulates the catalyst‐to‐oil ratio using a fixed‐bed reactor and a semibatch accumulator of liquids. Translation of data obtained from MAT tests in order to infer kinetic parameters to model continuous industrial units is, consequently, difficult and uncertain. In this work, the extraction of kinetic data obtained in a MAT reactor is analyzed. Estimation of a kinetic rate equation to evaluate instantaneous conversion in MAT reactors is performed. The activation energy obtained is kinetic and can be used during the modeling of riser reactors. It was possible, also, to infer values of the remaining catalytic activity after each experiment; these values were used to adjust a hyperbolic deactivation function, useful to model industrial riser reactors.
Improvement of a Model for Crystal Habit Prediction
Authors: Schmiech P. , Ulrich J.
Published: July 2004

Periodic Bond Chains (PBC‐vectors) are used to improve the results of the build‐in approach in order to predict crystal habits by means of molecular modeling. A computer program was developed to find the PBCs and to investigate their changes as a result of the presence of additives. As a result the build‐in approach could be improved by incorporating a correction factor and the predicted crystal habits by the PBC model are in a good agreement with experimental results.
Gas Cleaning Systems of Decentralized Hazardous Waste Incinerators in the Chemical Industry
Authors: Lehner M. , Hoffmann A.
Published: July 2004

Gaseous and/or liquid residues of chemical production processes are frequently disposed of in comparatively small hazardous waste incinerators directly on‐site. With respect to the extremely high pollutant emissions, multistage wet gas cleaning processes are used that consist in most cases of a quench, one or more wet scrubbers and an optional aerosol separation stage. In order to select a suitable design of the gas cleaning process and equipment, besides the specific technical performance of each apparatus, particularly economic criteria have to be considered, like maintenance as well as investment costs. Additionally, the choice of the suitable material of construction plays a major role, especially at the transition section of dry to wetted gas in the quench. The paper compares qualitatively or quantitatively different equipment and process alternatives towards their performance. The present comparison indicates that only the consideration of all relevant parameters yields an optimal solution.
Magneto‐Structural Characterization of Metallocene‐Bridged Nitronyl Nitroxide Diradicals by X‐Ray, Magnetic Measurements, Solid‐state NMR Spectroscopy, and Ab Initio Calculations
Authors: Sporer Christian , Heise Henrike , Wurst Klaus , Ruiz‐Molina Daniel , Kopacka Holger , Jaitner Peter , Köhler Frank , Novoa Juan J. , Veciana Jaume
Published: July 2004

In the paper by P. Jaitner, F. Köhler, J. J. Novoa, J. Veciana et al. published in1, there is an error in Equation (3) on p. 1361, which should read as given below; the numerical results are not affected.
Structural and Thermodynamic Properties of Group 13 Imidometallanes and Their Heavier Analogues.
Authors: Timoshkin Alexey Y. , Schaefer Henry F. III
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Novel Pyramidal MB7 (M: Li, Na, K, Rb, or Cs) Species: Structure and Aromaticity
Authors: Li Qian‐Shu , Gong Liang‐Fa
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Dissociation Potential Curves of Low‐Lying States in Transition Metal Hydrides. Part 2. Hydrides of Groups 3 and 5
Authors: Koseki Shiro , Ishihara Yohei , Fedorov Dmitri G. , Umeda Hiroaki , Schmidt Michael W. , Gordon Mark S.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Structures and Vibrational Frequencies of NaO3 and NaO3+: The Ionization Energy of NaO3
Authors: Lee Edmond P. F. , Wright Timothy G.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Infrared Signature of Structures Associated with the H+(H2O)n (n = 6 to 27) Clusters.
Authors: Shin J.‐W. , Hammer N. I. , Diken E. G. , Johnson M. A. , Walters R. S. , Jaeger T. D. , Duncan M. A. , Christie R. A. , Jordan K. D.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Novel Structural Behavior of Strontium Aluminate Doped with Europium.
Authors: Shi W. S. , Yamada H. , Nishikubo K. , Kusaba H. , Xu C. N.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Structure of a High‐Pressure Modification of the Bariumthioplatinate(II), BaPt2S3.
Authors: Huster J. , Bronger W.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A Comparison of the Crystal Structures of the Tetraammoniates of Lithium Halides, LiBr×4NH3 and LiI×4NH3, with the Structure of Tetramethylammonium Iodide, N(CH3)4I.
Authors: Jacobs Herbert , Barlage Holger , Friedriszik Martin
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Crystal Structure and Electrical Properties of the New Ln2MSi2 Compounds (Ln: Rare Earths; M: Fe, Co).
Authors: Merlo F. , Pani M. , Fornasini M. L.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and High Metallic Conductivity of Layer‐Structured Sr2N Thin Film Deposited onto MgO(001) Substrate.
Authors: Inumura Kei , Kuroda Yusuke , Sakamoto Koyo , Murashima Mika , Yamanaka Shoji
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Determining Extremely Low Sodium Activities at Elevated Temperatures.
Authors: Naefe H.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
The Ammonia, Thiosulfato, and Mixed Ammonia/Thiosulfato Complexes of Silver(I) and Gold(I).
Authors: Perera W. Nimal , Senanayake Gamini
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Crystal Structure of [C10N2H10]2 [P2Mo5O21(OH)2] ×2H2O.
Authors: Natarajan Srinirvasan , Ewald Bastian , Prots Yurii , Kniep Ruediger
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
BINOL—Salen‐Catalyzed Highly Enantioselective Alkyne Additions to Aromatic Aldehydes.
Authors: Li Zi‐Bo , Pu Lin
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Application of P,N‐Sulfinyl Imine Ligands to Iridium‐Catalyzed Asymmetric Hydrogenation of Olefins.
Authors: Schenkel Laurie B. , Ellman Jonathan A.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Enantiomerically Pure Amines as Substrates for the Ti‐Catalyzed Hydroamination of Alkynes.
Authors: Pohlki Frauke , Bytschkov Igor , Siebeneicher Holger , Heutling Andreas , Koenig Wilfried A. , Doye Sven
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A Facile Synthesis of (E,Z)‐3‐Chloro‐2‐propenamides, Acids, and Esters from 2,3‐Acetylenic Acids with Oxalyl Chloride in DMF.
Authors: Urdaneta Neudo A. , Salazar Jose , Herrera Julio C. , Lopez Simon E.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Improved Protocol for the Diastereoselective Cyclopropanation of Alkenes Using Geminal Dizinc Carbenoids: A Study on the Effect of Zinc Iodide.
Authors: Fournier Jean‐Francois , Charette Andre B.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Simple Strategy for the Immobilization of Dirhodium Tetraprolinate Catalysts Using a Pyridine‐Linked Solid Support.
Authors: Davies Huw M. L. , Walji Abbas M. , Nagashima Tadamichi
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A New Highly Chemoselective Isomerization of Allylamides.
Authors: Neugnot Benjamin , Cintrat Jean‐Christophe , Rousseau Bernard
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Aerobic Oxidation of Cycloalkanes, Alcohols and Ethylbenzene Catalyzed by the Novel Carbon Radical Chain Promoter NHS (N‐Hydroxysaccharin).
Authors: Baucherel Xavier , Gonsalvi Luca , Arends Isabel W. C. E. , Ellwood Simon , Sheldon Roger A.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
An Easy Way for Constructing Hard‐to‐Make Epoxides Employing HOF×CH3CN.
Authors: Golan Elizabeth , Hagooly Aviv , Rozen Shlomo
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Pd/C‐Catalyzed Transfer‐Hydrogenation of Benzaldehydes to Benzyl Alcohols Using Potassium Formate as the Selective Hydrogen Donor.
Authors: Baidossi Mubeen , Joshi Ashutosh V. , Mukhopadhyay Sudip , Sasson Yoel
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Zirconium Borohydride Piperazine Complex: An Efficient, Air and Thermally Stable Reducing Agent.
Authors: Tajbakhsh M. , Lakouraj M. M. , Shirini F. , Habibzadeh S. , Nikdoost A.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Zirconium(IV) Chloride Catalyzed Ring Opening of Epoxides with Aromatic Amines.
Authors: Swamy N. Raghavendra , Goud T. Venkateshwar , Reddy S. Malla , Krishnaiah P. , Venkateswarlu Y.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A Convenient and Effective Method for Synthesizing β‐Amino‐α,β‐Unsaturated Esters and Ketones
Authors: Gao Yuanhe , Zhang Qihan , Xu Jiaxi
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A Novel and Highly Selective Conversion of Alcohols, Thiols, and Silyl Ethers to Azides Using the Triphenylphosphine/2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ)/n‐Bu4NN3 System.
Authors: Iranpoor Nasser , Firouzabadi Habib , Akhlaghinia Batool , Nowrouzi Najmeh
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Stereoselective Preparation of Conjugated E‐Enynes from E‐Vinylic Tellurides and Terminal Alkynes via Sonogashira Cross‐Coupling.
Authors: Zeni Gilson , Alves Diego , Pena Jesus M. , Braga Antonio L. , Stefani Helio A. , Nogueira Cristina W.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A Simple One‐Step Protocol for the Olefination of Vinylogous Formamides.
Authors: Kumar Vijay , Chimni Swapandeep Singh , Kumar Subodh
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Sulfamic Acid as a Cost‐Effective and Recyclable Catalyst for Liquid Beckmann Rearrangement, a Green Process to Produce Amides from Ketoximes Without Waste.
Authors: Wang Bo , Gu Yanlong , Luo Cheng , Yang Tao , Yang Liming , Suo Jishuan
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Halide‐Free Dehydrative Allylation Using Allylic Alcohols Promoted by a Palladium—Triphenyl Phosphite Catalyst.
Authors: Kayaki Yoshihito , Koda Takashi , Ikariya Takao
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Zirconium(IV) Chloride as a New, Highly Efficient, and Reusable Catalyst for Acetylation of Phenols, Thiols, Amines, and Alcohols under Solvent‐Free Conditions
Authors: Chakraborti Asit K. , Gulhane Rajesh
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of N‐Benzylated Anilines from the Reaction of Anilines and Benzyl Chloroformate.
Authors: Pati Hari , Weisbruch Paul , Lemon Adrienne , Lee Moses
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Image Analysis as a Quantitative Screening Test in Combinatorial Catalysis: Discovery of an Unexpected Ruthenium‐Based Catalyst for the Sonogashira Reaction.
Authors: Garbacia Stefania , Touzani Rachid , Lavastre Olivier
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Mild Diazo Transfer Reaction Catalyzed by Modified Clays.
Authors: de S. Rianelli Renata , de Souza Maria Cecilia B. V. , Ferreira Vitor F.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Hydroxytriamides as Potent γ‐Secretase Inhibitors.
Authors: Prasad C. V. C. , et al. et al.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Microwave‐Assisted Amination from Aryl Triflates Without Base and Catalyst.
Authors: Xu Gang , Wang Yan‐Guang
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Ag‐Catalyzed Asymmetric Mannich Reactions of Enol Ethers with Aryl, Alkyl, Alkenyl, and Alkynyl Imines.
Authors: Josephsohn Nathan S. , Snapper Marc L. , Hoveyda Amir H.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A General and Mild Ullmann‐Type Synthesis of Diaryl Ethers.
Authors: Cristau Henri‐Jean , Cellier Pascal P. , Hamada Samy , Spindler Jean‐Francis , Taillefer Marc
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Bismuth Compounds in Organic Synthesis. Bismuth Nitrate Catalyzed Chemoselective Synthesis of Acylals from Aromatic Aldehydes.
Authors: Aggen David H. , Arnold Joshua N. , Hayes Patrick D. , Smoter Nathaniel J. , Mohan Ram S.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Sulfonyl‐phenyl‐ureido Benzamidines: A Novel Structural Class of Potent Antimalarial Agents
Authors: Leban Johann , Pegoraro Stefano , Dormeyer Matthias , Lanzer Michael , Aschenbrenner Andrea , Kramer Bernd
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Ru(II)‐Catalyzed Chemo‐ and Regioselective Cyclotrimerization of Three Unsymmetrical Alkynes Through Boron Temporary Tether. One‐Pot Four‐Component Coupling via Cyclotrimerization/Suzuki—Miyaura Coupling.
Authors: Yamamoto Yoshihiko , Ishii Jun‐ichi , Nishiyama Hisao , Itoh Kenji
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Rhodium‐Catalyzed Asymmetric Ring Opening of Oxabicyclic Alkenes with Sulfur Nucleophiles.
Authors: Leong Paul , Lautens Mark
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
An Alternative Procedure for the Synthesis of [5]‐ and [7]Carbohelicenes.
Authors: El Abed Riadh , Ben Hassine Bechir , Genet Jean‐Pierre , Gorsane Mohamed , Marinetti Angela
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of Cycloalkenyl and Alkenyloxiranes from Allylic Sulfoximines and Aldehydes and Application to Solid‐Phase Synthesis.
Authors: Gais Hans‐Joachim , Babu Gadamsetti S. , Guenter Markus , Das Parthasarathi
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Enzymatic Resolution of 5‐Phenylselanyltetrahydro‐2‐furanone. Enantioselective Preparation of (R)‐ and (S)‐γ‐Valerolactone.
Authors: Clososki Giuliano C. , Costa Carlos E. , Missio Lauri J. , Cass Quezia B. , Comasseto Joao V.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Sulfonamido, Azidosulfonyl and N‐Acetylsulfonamido Analogues of Rofecoxib: 4‐[4‐(N‐Acetylsulfonamido)phenyl] ‐3‐(4‐methanesulfonylphenyl)‐2(5H)furanone is a Potent and Selective Cyclooxygenase‐2 Inhibitor.
Authors: Zarghi Afshin , Rao P. N. Praveen , Knaus Edward E.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Efficient Isomer‐Pure Synthesis of a Benzo[b]thiophene Analogue of Pentacene.
Authors: Wex Brigitte , Kaafarani Bilal R. , Neckers Douglas C.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Use of a Design of Experiments Approach for the Optimization of a Microwave‐Assisted Ugi Reaction.
Authors: Tye Heather , Whittaker Mark
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
A Practical Two‐Step Synthesis of 3‐Alkyl‐2,3‐dihydro‐1H‐isoindolin‐1‐ones.
Authors: Ruan Yuan‐Ping , Chen Ming‐De , He Ming‐Zhu , Zhou Xiang , Huang Pei‐Qiang
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Crude D‐(+)‐Glyceraldehyde Obtained from D‐Mannitol‐Diacetonide by Oxidative Cleavage with Sodium Periodate: Its Reactions with Nucleophilic Species.
Authors: de O. Domingos Jorge L. , de A. Vilela Guilherme V. M. , Costa Paulo R. R. , Dias Ayres G.
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
Umpolung of the 5‐Alkyl‐2‐dimethylamino‐1,3‐dithiolium‐4‐thiolate Mesoion and Its Application in the Synthesis of Some New Tetrathiafulvalenes.
Authors: Hellberg Jonas , Dahlstedt Emma , Woldegiorgis Andreas
Published: July 2004

For Abstract see ChemInform Abstract in Full Text.
N‐Acridin‐9‐yl‐butane‐1,4‐diamine Derivatives: High Affinity Ligands of the α2δ Subunit of Voltage Gated Calcium Channels.
Authors: Lim Jongwon , et al. et al.
Published: July 2004

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Synthesis of New 4,5‐Dihydro‐3(2H)‐pyridazinone Derivatives.
Authors: Meyer E. , Joussef A. C. , Gallardo H. , de Souza L. de B. P.
Published: July 2004

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An Efficient Synthesis of 3‐Substituted 3H‐Pyrimidin‐4‐ones.
Authors: Jeong Jae Uk , Chen Xiahong , Rahman Attiq , Yamashita Dennis S. , Luengo Juan I.
Published: July 2004

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A Convenient Synthesis of Octahydropyrazino[1,2‐a]pyrazine.
Authors: Liang Feng , Wu Xiao‐Jun , Zhang Shi‐Wei , Wu Cheng‐Tai
Published: July 2004

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Efficient, Stereoselective Synthesis of trans‐2,5‐Disubstituted Morpholines.
Authors: Lanman Brian A. , Myers Andrew G.
Published: July 2004

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Synthesis of 3,4,5,6‐Tetrahydro‐2H‐1,3,4‐oxadiazin‐2‐ones Employing a Metal Hydride and Diethyl Carbonate: An Alternative Cyclization Method over 1,1′‐Carbonyldiimidazole.
Authors: Casper David M. , Kieser David , Blackburn Jennifer R. , Hitchcock Shawn R.
Published: July 2004

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A Study of the Aryl—Aryl Coupling Reactions of (4‐X‐C6H4)Ph2P=O.
Authors: Czupik Michaela , Bankey Nathaniel , Fossum Eric
Published: July 2004

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Thyonosides A and B, Two New Saponins Isolated from the Holothurian Thyone aurea.
Authors: Bonnard Isabelle , Rinehart Kenneth L.
Published: July 2004

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A Novel Iridoid from Boschniakia rossica.
Authors: Yim Soon‐Ho , Kim Hyun Jung , Liu Yong Zhen , Lee Ik‐Soo
Published: July 2004

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A Novel Approach to Synthesis of Tricyclic Diterpenoid.
Authors: Peng Xuanjia , She Xuegong , Su Ying , Wu Tongxin , Pan Xinfu
Published: July 2004

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Diterpenes and Norditerpenes from the Roots of Dorystoechas hastata.
Authors: Ulubelen A. , Mericli A. H. , Mericli F.
Published: July 2004

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Antimalarial Activities of (+)‐Deoxoartemisitene and Its Novel C‐11, 13 Derivatives.
Authors: Jung Mankil , Lee Kyunghoon , Jung Hochul , Kendrick Howard , Yardley Vanessa , Croft Simon L.
Published: July 2004

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Potent and Selective Inhibitors of Bacterial Methionyl tRNA Synthetase Derived from an Oxazolone—Dipeptide Scaffold
Authors: Tandon Manish , Coffen David L. , Gallant Paul , Keith Dennis , Ashwell Mark A.
Published: July 2004

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A Concise, High Yield Synthesis of the Selective ECE‐Inhibitor, CGS 35066.
Authors: Fauq Abdul H. , Khan Murad A. , Eckman Christopher
Published: July 2004

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Transmission of Axial Chirality to Spiro Center Chirality, Enabling Enantiospecific Access to Erythrinan Alkaloids.
Authors: Yasui Yoshizumi , Suzuki Keisuke , Matsumoto Takashi
Published: July 2004

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Arabinosylamine in Asymmetric Syntheses of Chiral Piperidine Alkaloids.
Authors: Kranke Birgit , Hebrault Dominique , Schultz‐Kukula Martin , Kunz Horst
Published: July 2004

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Nucleosides. Part 65. Synthesis of New Pteridine—N8—Nucleosides
Authors: Matysiak Stefan , Waldscheck Bernhard , Pfleiderer Wolfgang
Published: July 2004

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New Flavonoids from Oxytropis myriophylla.
Authors: Lu Jiang‐hai , Liu Yi , Zhao Yu‐ying , Tu Guang‐zhong
Published: July 2004

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Phenolic Sodium Sulfates of Frankenia laevis L.
Authors: Hussein S. A. M.
Published: July 2004

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Improved Procedures for Preparation of Racemic Capreomycidine.
Authors: Yamashita Ayako , Norton Emily B. , Mansour Tarek S.
Published: July 2004

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Structure—Activity Relationships of Untenone A and Its Derivatives for Inhibition of DNA Polymerases.
Authors: Saito Fumiyo , Takeuchi Ryo , Kamino Tomoyuki , Kuramochi Kouji , Sugawara Fumio , Sakaguchi Kengo , Kobayashi Susumu
Published: July 2004

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First Total Synthesis of trans‐ and cis‐Resorcylide: Remarkable Hydrogen‐Bond‐Controlled, Stereospecific Ring‐Closing Metathesis.
Authors: Couladouros Elias A. , Mihou Anastasia P. , Bouzas Emmanuel A.
Published: July 2004

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Extra‐Large‐Pore Zeolites with Two‐Dimensional Channels Formed by 14 and 12 Rings.
Authors: Paillaud Jean‐Louis , Harbuzaru Bogdan , Patarin Joel , Bats Nicolas
Published: July 2004

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A New Series of Estrogen Receptor Modulators: Effect of Alkyl Substituents on Receptor‐Binding Affinity.
Authors: Kamada Atsushi , Sasaki Atsushi , Kitazawa Noritaka , Okabe Tadashi , Nara Kazumasa , Hamaoka Shinichi , Araki Shin , Hagiwara Hiroaki
Published: July 2004

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Neutron Scattering Studies of Nanomagnetism and Artificially Structured Materials
Authors: Fitzsimmons M. R. , Bader S. D. , Borchers J. A. , Felcher G. P. , Furdyna J. K. , Hoffmann A. , Kortright J. B. , Schuller Ivan K. , Schulthess T. C. , Sinha S. K. , et al. et al.
Published: July 2004

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Metal Encapsulated Nanotubes of Silicon and Germanium
Authors: Singh Abhishek Kumar , Kumar Vijay , Kawazoe Yoshiyuki
Published: July 2004

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The Profound Influence of a Single Metal‐Carbon Bond on the Reactivity of Bio‐Relevant Cobalt(III) Complexes
Authors: Hamza Mohamed S. A. , van Eldik Rudi
Published: July 2004

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Nω‐Hydroxy‐L‐arginine and Its Homologoues. Chemical and Biological Properties
Authors: Beranova Petra , Chalupsky Karel , Entlicher Gustav
Published: July 2004

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Applications of Trivalent and Pentavalent Tantalum in Organic Synthesis
Authors: Chandrasekhar Srivari , Ramachandar Tokala , Shyamsunder Tokala
Published: July 2004

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Enantioselective Routes to Sulfoxides Based upon the Use of Carbanionic Leaving Groups
Authors: Capozzi Maria Annunziate M. , Cardellicchio Cosimo , Naso Francesca
Published: July 2004

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Recent Advances on the Sharpless Asymmetric Aminohydroxylation
Authors: Nilov Dmitry , Reiser Oliver
Published: July 2004

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[3+2] Cycloaddition of Trimethylenemethane and Its Synthetic Equivalents
Authors: Yamago Shigeru , Nakamura Eiichi
Published: July 2004

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Catalytic Interconversions of Five‐ and Six‐Membered Oxygen‐Containing Heterocyclic Compounds
Authors: Andersons Andris , Simonyan Svetlana , Lukevics Edmunds
Published: July 2004

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Fluorine‐Containing Heterocycles. Part 1. Synthesis of Intramolecular Cyclization
Authors: Furin Georgii G.
Published: July 2004

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Acetylenic Derivatives of Quinones
Authors: Shvartsberg M. S. , Barabanov I. I. , Fedenok L. G.
Published: July 2004

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Synthesis and Functions of Macrocycles Utilizing Self‐Assembling
Authors: Houjou Hirohiko , Kanesato Masatoshi , Hiratani Kazuhisa
Published: July 2004

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Dietary Phytoestrogens and Health
Authors: Cornwell Teresa , Cohick Wendie , Raskin Ilya
Published: July 2004

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Novel π‐Conjugated Nano‐Supramolecules Having Fine‐Controlled Metal‐Assembling Functions
Authors: Higuchi Masayoshi , Yamamoto Kimihisa
Published: July 2004

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Application of Microwave Irradiation in the Synthesis of Carbohydrates
Authors: Das Saibal Kumar
Published: July 2004

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Simple Syntheses of Seven‐Membered Rings via an Entropy/Strain Reduction Strategy
Authors: Byrne Louise A. , Gilheany Declan G.
Published: July 2004

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Dehydrocoupling of Hydrosilanes to Polysilanes and Silicon Oligomers: A 30 Year Overview
Authors: Corey Joyce Y.
Published: July 2004

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Recent Chemistry of the Diboron Compounds
Authors: Dembitsky Valery M. , Ali Hijazi Abu , Srebnik Morris
Published: July 2004

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Palladium‐Catalyzed Reactions in Ionic Liquids
Authors: Welton Tom , Smith Paul J.
Published: July 2004

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Metallodendritic Materials for Heterogenized Homogeneous Catalysis
Authors: Bourrier Olivier , Kakkar Ashok K.
Published: July 2004

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Recent Advances in Oligonucleotide Synthesis and Their Applications
Authors: Vaijayanthi B. , Kumar P. , Ghosh P. K. , Gupta K. C.
Published: July 2004

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Decoration of Dihydropyrimidine and Dihydropyridine Scaffolds with Sugars via Biginelli and Hantzsch Multicomponent Reactions: An Efficient Entry to a Collection of Artificial Nucleosides
Authors: Dondoni Alessandro , Massi Alessandro
Published: July 2004

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Catalytic and Biological Activity of Organic Complexes of Precious Metals (A Review)
Authors: Evstigneeva R. P. , Pchelkin V. P.
Published: July 2004

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Furan‐2,3‐diones: Convenient Synthons in Heterocyclic Chemistry
Authors: Kollenz Gert , Leber Sabine
Published: July 2004

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The Chemistry and Biology of Lapachol and Related Natural Products: α‐ and β‐Lapachones
Authors: Ravelo Angel G. , Estevez‐Braun Ana , Perez‐Sacau Elisa
Published: July 2004

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Bissulfoximine Ligands in Asymmetric Synthesis
Authors: Harmata Michael
Published: July 2004

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Basics of Combinatorial Chemistry
Authors: Vanier Cecile , Wagner Alain
Published: July 2004

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Transition‐Metal‐Catalyzed Reactions in Heterocyclic Synthesis
Authors: Nakamura Itaru , Yamamoto Yoshinori
Published: July 2004

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Solid‐Phase Oligosaccharide Synthesis
Authors: Seeberger Peter H.
Published: July 2004

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Synthesis of Heterocycles via Group VI Fischer Carbene Complexes
Authors: Barluenga Jose , Santamaria Javier , Tomas Miguel
Published: July 2004

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Synthesis of Heterocycles via Palladium π‐Olefin and π‐Alkyne Chemistry
Authors: Zeni Gilson , Larock Richard C.
Published: July 2004

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Chiral Heterocycles by Iminium Ion Cyclization
Authors: Royer Jacques , Bonin Martine , Micouin Laurent
Published: July 2004

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1‐Azaallylic Anions in Heterocyclic Chemistry
Authors: Mangelinckx Sven , Giubellina Nicola , De Kimpe Norbert
Published: July 2004

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The Pummerer Reaction: Methodology and Strategy for the Synthesis of Heterocyclic Compounds
Authors: Bur Scott K. , Padwa Albert
Published: July 2004

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Heterocycles Derived from Heteroatom‐Substituted Carbenes
Authors: Cheng Ying , Meth‐Cohn Otto
Published: July 2004

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Thiazole‐Mediated Synthetic Methodology
Authors: Dondoni Alessandro , Marra Alberto
Published: July 2004

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Pentathiepins
Authors: Konstantinova Lidia S. , Rakitin Oleg A. , Rees Charles W.
Published: July 2004

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Solubility of Solids and Liquids in Cryogenic Liquids
Authors: Szczepaniec‐Cieciak Elzbieta
Published: July 2004

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Adiabatic and Nonadiabatic Proton Transfer Rate Constants in Solution
Authors: Kiefer Philip M. , Hynes James T.
Published: July 2004

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Powering Nanodevices with Biomolecular Motors
Authors: Hess Henry , Bachand George D. , Vogel Viola
Published: July 2004

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Effects of milk fat replacement by PUFA enriched fats on n‐3 fatty acids, conjugated dienes and volatile compounds of fermented milks
Authors: Luna Pilar , Martín‐Diana Ana Belén , Alonso Leocadio , Fontecha Javier , Angel de la Fuente Miguel , Requena Teresa , Juárez Manuela
Published: July 2004

A study was carried out to determine the profiles of fatty acids in fermented milks and dairy derivatives made with milk fat substituted by polyunsaturated fatty acid (PUFA)‐enriched fat. In order to improve the organoleptic properties of those products, whey protein concentrates (WPC) were added during the manufacturing process. Interest was focused during manufacturing and storage period on the contents of “healthy” fatty acids, mainly conjugated linoleic acid and n‐3 PUFA. Contents of these fatty acids were not affected by the manufacture practices and neither did addition of WPC during manufacturing nor cold storage cause their decrease. Percentages of total n‐3 fatty acids in fat from dairy derivatives enriched in PUFA after 21 d of storage (1.45%) were very close to those obtained before processing (1.39%). Contents did not differ either substantially when WPC were added during manufacturing (1.46%). The increase of volatile compounds was also examined. Although a slight decrease in the total volatile content was observed, percentages of different compounds were not modified when milk fat was substituted by PUFA enriched fat.
Lipid‐activated nuclear receptors: from gene transcription to the control of cellular metabolism
Authors: Crestani Maurizio , Mitro Nico , De Fabiani Emma
Published: July 2004

Cellular homeostasis is maintained through a complicated network of signaling, transport and enzymatic events that take place in different compartments of the cell. The result of this composite network determines the cellular behavior in response to environmental challenges. Within this network, many cellular functions are regulated at the transcriptional level and consequently the comprehension of the molecular mechanisms of gene regulation is fundamental to fully understand how the cell reacts to environmental changes. Moreover, it offers an opportunity to find novel targets for the design of better strategies to improve healthy human nutrition and to treat metabolic diseases. In this framework, nuclear receptors have emerged as key regulators of many cellular functions in response to lipid action. In this review, we will discuss the new concepts on the biology of the recently “adopted” nuclear receptors sensing oxysterols (LXR), bile acids (FXR) and fatty acids (PPARs) and their function in the integrated regulation of lipid and glucose metabolism. We will also address the role played by other orphan nuclear receptors, such as FTF, SHP and HNF‐4, acting in concert with these lipid‐sensing nuclear receptors in the regulation of cellular metabolism.
A palmitoleic acid ester concentrate from seabuckthorn pomace
Authors: Rüsch gen. Klaas Mark , Meurer Peter U.
Published: July 2004

The pomace from seabuckthorn juice production is generally considered waste. In this work it was utilized as a raw material for the production of a palmitoleic acid (cis‐Δ9‐C16) methyl ester concentrate. The raw material contains only about 15% palmitoleic acid in its oil. Concentration steps are air classifying (to remove the seeds, which do not contain valuable amounts of palmitoleic acid), transesterification, and distillation (to obtain a C16 fraction) and finally urea adduct crystallization (to remove saturates). A product containing of 82% palmitoleic acid methyl ester was obtained without using any methods unsuitable for technical application. Such a concentrate is not yet available on the market. For comparison macadamia nut oil was also used as a starting material, but regarding both economy and product quality seabuckthorn pomace is the superior raw material base.
Production and properties of 7,10,12‐trihydroxy‐8(E)‐octadecenoic acid from ricinoleic acid conversion by Pseudomonas aeruginosa
Authors: Kuo Tsung Min , Knothe Gerhard
Published: July 2004

This study was undertaken to produce a novel antifungal compound, 7,10,12‐trihydroxy‐8(E)‐octadecenoic acid (7,10,12‐THOD), in large quantities for determining its properties by use of crude ricinoleic acid as converted by Pseudomonas aeruginosa NRRL B‐23260. A useful reactor process was developed by employing a unique aeration mechanism and a new agitation device. The aeration mechanism involved a filtered airflow constantly supplied from the top through two ports on the headplate at 220 mL/min and at varied rates as needed and regulated through a bottom sparger, to control foaming. The agitation device combined a marine impeller and an open turbine to overcome the early phase of oxygen depletion and enhance production yields. A yield of 40% was achieved after 77 h of reaction when down‐stream processing of the bioproduct was most suitable. 7,10,12‐THOD was crystallized from ethyl acetate extracts of the reactor broth following a sequential cooling process to −20 °C. The melting point of 7,10,12‐THOD was 94.5–95.0 °C. The 1H‐ and 13C‐NMR signals of all protons and carbons in the 2(E)‐ene‐1,4,6‐triol moiety of 7,10,12‐THOD were now assigned, also with the aid of various 2D techniques. 7,10,12‐THOD was found to exhibit a unique surface‐active property. This study provides basic information and process technology for potential new uses of 7,10,12‐THOD.