bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Characterization of Broccoli-like Ag/Cu2O Nanostructures on ZnO Nanowires Using the Plasma–Liquid Interaction Method
Authors: Thu Phung Thi , Bach Ta Ngoc , Phong Le Thi Hong , Tung Do Hoang , Ky Vu Hong , Tung Do Khanh , Lam Vu Dinh , Manh Do Hung , Dan Nguyen Huy , Anh Trinh Xuan , Le Ngo Thi Hong
Published: March 2024

We have designed an excellent visible-light-driven and high-performance photocatalyst with a Ag-Cu2O-ZnO nanowire heterostructure in our work by combining the hydrothermal approach with plasma–liquid technology. The structural and morphological characteristics and optical properties of the samples were evaluated using X-ray diffraction, field-emission scanning electron microscopy, and spectrophotometry, respectively. The results show that the Ag nanoparticles are mainly positioned on the Cu2O nanoclusters compared with the ZnO nanowire surface, forming broccoli-like Ag-Cu2O nanoclusters during the Ar gas plasma treatment process in an aqueous solution. The diameter of the Ag/Cu2O nanoclusters ranges from 150 to 180 nm. The Ag-Cu2O-ZnO nanowires exhibited improved photocatalytic performance, decomposing approximately 98% methyl orange dye in 30 min. This is a consequence of the synergistic interactions between the p-n heterojunction formed at the Cu2O-ZnO interfaces and the localized surface plasmon resonance (LSPR) effect of the Ag nanoparticles, which broaden the visible light absorption range and effectively separate the photogenerated charge carriers.
Integra® Dermal Regeneration Template in Complex Scalp Reconstruction
Authors: Turton Natalie , Aggarwal Aaina , Twohig Eoin , Gallagher James , McVeigh Kieron , Barnard Neal , Payne Karl
Published: March 2024

Background/Objectives: The need for surgical reconstruction of scalp defects following the excision of cutaneous skin cancers is an increasingly common procedure. Particular challenges arise when considering options for reconstruction of large defects not amenable to local skin flap coverage. The use of skin grafts poses the risk of donor site morbidity. This paper investigates the emerging use of Integra®, a synthetic acellular dermal regeneration template, as an alternative or adjunct to skin grafting in scalp reconstruction. Methods: The study presents a retrospective analysis of 101 patients who underwent Integra®-based reconstruction of scalp defects. Demographics, procedure details, complications, need for further surgery, and time to healing were evaluated. Results: The overall success rate of the one-stage Integra®-only procedure was 95%, with a minor complication rate of 30.7%. Anticoagulation medication was identified as an independent risk factor for post-operative infection, while previous head and neck radiotherapy and increased defect depth were associated with the requirement for a second-stage skin graft. Conclusions: These findings support the consideration of Integra® as a safe and viable alternative for both partial and full thickness scalp defects in a select cohort of complex highly co-morbid patients, reducing complications and the need for additional procedures.
Six-Year, Real-World Use of Prophylaxis with Recombinant Factor IX–Albumin Fusion Protein (rIX-FP) in Persons with Hemophilia B: A Single-Center Retrospective–Prospective Study
Authors: Coppola Antonio , Rivolta Gianna Franca , Quintavalle Gabriele , Matichecchia Annalisa , Riccardi Federica , Rossi Rossana , Benegiamo Anna , Ranalli Paola , Coluccio Valeria , Tagliaferri Annarita
Published: March 2024

Background: Extended half-life (EHL) factor IX (FIX) concentrates allow for prophylaxis with prolonged dosing intervals and high bleeding protection in persons with hemophilia B. Long-term real-world studies are lacking. Methods: In a retrospective–prospective study, the six-year use of prophylaxis with the EHL recombinant FIX–albumin fusion protein (rIX-FP) was analyzed, comparing outcomes with previous standard half-life (SHL) FIX in patients already on prophylaxis. Results: Prophylaxis with rIX-FP was prescribed in 15 patients (10 severe, 5 moderate; follow-up: 57 ± 17 months). Based on a pharmacokinetic assessment and clinical needs, the first regimen was 47 ± 7 IU/Kg every 9 ± 2 days. All but one patient remained on rIX-FP prophylaxis, adjusting infusion frequency and/or dose; the last prescribed frequency was ≥10 days in 10/13 patients, being reduced in seven and increased in four vs. the first regimen. The weekly FIX dose was unchanged; FIX trough levels were >5% in all patients. The annual infusion number and FIX IU/Kg significantly decreased (~60%) in eight patients previously on SHL FIX prophylaxis, with similar concentrate costs. Very low bleeding rates (most traumatic bleeds and the last quartile of the infusion interval), improved orthopedic and pain scores, unchanged HEAD-US scores and problem joints, and high treatment adherence (>90%) and satisfaction were registered. Conclusions: Personalized, carefully adjusted rIX-FP regimens contribute to the diffusion and optimization of prophylaxis in persons with severe and moderate hemophilia B, with long-term favorable bleeding, joint, and patient-reported outcomes.
Correction: Jiménez-Ortigosa et al. Cryo-Electron Tomography of Candida glabrata Plasma Membrane Proteins. J. Fungi 2021, 7, 120
Authors: Jiménez-Ortigosa Cristina , Jiang Jennifer , Chen Muyuan , Kuang Xuyuan , Healey Kelley R. , Castellano Paul , Boparai Nikpreet , Ludtke Steven J. , Perlin David S. , Dai Wei
Published: March 2024

The authors wish to update the article title to “Cryo-Electron Tomography of Candida glabrata Plasma Membrane Proteins” [...]
Experimental and Numerical Analysis of Torsional—Lateral Vibrations in Drive Lines Supported by Hydrodynamic Journal Bearings
Authors: Stefani Fabrizio Antonio , Niccolini Marmont Du Haut Champ Carlo Alberto , Silvestri Paolo , Massardo Aristide Fausto
Published: March 2024

The driving and resistance torques of some rotating machinery for industrial applications are nonstationary and affect system dynamics. Under such operating conditions, coupling between torsional and lateral vibrations may become significant for drive lines supported by hydrodynamic bearings in particular design configurations. Indeed, the occurrence of fluid–structure interactions causes a reduction in the stability threshold of the journal bearings. A hypothesis based on Hopf bifurcation theory (HBT), which justifies how the coupling phenomenon develops, is validated by means of overall experimental observations and a suitable numerical model. When the pulsating driving torque induces significant angular speed oscillation, the rotor-bearing system lateral operating response becomes more complex, and bearing instability onset is detected. Such observation proves the influence of bearings in converting torsional oscillations to lateral vibrations. Particularly, during run-up and run-down tests, localized hysteresis is observed in trends of fundamental order contents. The numerical model of the hydrodynamic bearings solves the Reynolds equation in unsteady conditions to quantify the lateral vibrations amplitude in the presence of both angular speed oscillation and dynamic perturbation. The proposed approach proves the onset of torsional–lateral vibration coupling due to hydrodynamic bearings, to a certain extent. The detected hysteresis phenomena can also be explained by the onset of journal bearing instability.
The Influence of the Shielding-Gas Flow Rate on the Mechanical Properties of TIG-Welded Butt Joints of Commercially Pure Grade 1 Titanium
Authors: Szwajka Krzysztof , Zielińska-Szwajka Joanna , Trzepieciński Tomasz
Published: March 2024

This article proposes as a novelty the differentiation of shielding-gas flow rates from both sides of the tungsten inert gas (TIG)-welded butt joints of commercially pure (CP) grade 1 titanium tubes. Such an approach is aimed at economically reducing the amount of protective gas used in TIG closed butt welding. The effect of the shielding-gas flow rate on the properties of CP grade 1 titanium butt-welded joints made using the tungsten inert gas (TIG)-welding method. Butt-welded joints were made for different values of the shielding-gas flow from the side of the root of the weld. Argon 5.0 was used as the shielding gas in the welding process. As part of the research, the welded joints obtained were analysed using optical and scanning electron microscopy. The microstructural characteristics of the joints were examined using an optical microscope, and the mechanical properties were determined using hardness and tensile tests. It was observed that as the flow of the shielding gas decreases, the hardness of the weld material increases and its brittleness also increases. A similar trend related to the amount of gas flow was also noticeable for the tensile strength of the joints. The increase in the hardness of the weld and the heat-affected zone compared to the base metal is mainly related to the increase in the amount of acicular structure (α′ phase). The optimal gas flow rates from the side of the root of weld were found at the values of 12 dm3/min.
Soft Tissue Substitutes in Periodontal and Peri-Implant Soft Tissue Augmentation: A Systematic Review
Authors: Rotundo Roberto , Pancrazi Gian Luca , Grassi Alessia , Ceresoli Lara , Di Domenico Giovanna Laura , Bonafede Vanessa
Published: March 2024

Background: Different extracellular matrix (ECM)-based technologies in periodontal and peri-implant soft tissue augmentation have been proposed in the market. The present review compared the efficacy of soft tissue substitutes (STSs) and autogenous free gingival grafts (FGGs) or connective tissue grafts (CTGs) in mucogingival procedures to increase keratinized tissue (KT) width around teeth and implants. Methods: Two independent examiners performed an electronic search on MEDLINE and the Cochrane Library based on the following PICOS format: (P) adult patients; (I) soft tissue substitutes and FGGs/CTGs; (C) STSs vs. CTGs; STSs vs. FGGs; STSs vs control; (O) KT width gain; (S) systematic reviews, randomized controlled trials. Studies published before November 2023 were included. Results: Around teeth, all biomaterials showed superior performance compared to a coronally advanced flap (CAF) alone for treating gingival recessions. However, when compared to CTGs, acellular dermal matrices (ADMs) yield the most similar outcomes to the gold standard (CTGs), even though in multiple recessions, CTGs continue to be considered the most favorable approach. The use of STSs (acellular matrix or tissue-engineered) in combination with apically positioned flaps (APF) resulted in significantly less gain in KT width compared to that achieved with FGGs and APFs. Around dental implants, free gingival grafts were deemed more effective than soft tissue substitutes in enhancing keratinized mucosa width. Conclusions: Based on the available evidence, questions remain about the alternative use of soft tissue substitutes for conventional grafting procedures using free gingival grafts or connective tissue grafts around teeth and implants.
Apraxia Patterns for the Differentiation between Alzheimer’s Disease and Frontotemporal Dementia Variants
Authors: Papadopoulos Georgios , Parissis Dimitrios , Gotzamani-Psarrakou Anna , Ioannidis Panagiotis
Published: March 2024

Background and Objectives: Despite the increasing use of biomarkers, differentiation between Alzheimer’s disease (AD), behavioral variant Frontotemporal Dementia (bvFTD), and Primary Progressive Aphasia (PPA) remains a challenge. Apraxia is a supportive feature for diagnosing AD but is underrepresented in other dementia types. Herein, we investigated the presence and characteristic profiles of limb, verbal, and non-verbal apraxia in three major dementia types. Materials and Methods: Test for Upper Limb Apraxia (TULIA) and Apraxia Battery for Adults—2 (ABA-2) were administered in patients with AD (n = 22), bvFTD (n = 41), and PPA (n = 22), with 20 individuals serving as healthy controls (HC). Composite and subdomain scores were compared between each patient group and the HC. Praxis profiles indicative of each dementia type and a possible predictive value were sought. Results: Apraxia provided high diagnostic accuracy for detecting dementia compared with HC (sensitivity: 63.6–100%, specificity: 79.2–100%). Patients with AD performed worse when imitating intransitive gestures as well as pantomiming transitive gestures (mean differences: 2.10 and 3.12, respectively), compared with bvFTD. PPA patients, compared with bvFTD, had comparable results in limb, verbal, and non-verbal praxis assessments, despite the greater deterioration in the outcome. Compared with patients with AD, PPA had increased pathological outcomes in verbal (86.4% vs. 40.9%) and non-verbal apraxia (31.8% vs. 0%), while bvFTD had increased pathological outcomes in verbal apraxia (85.4% vs. 44.5%). Finally, apraxia is correlated with cognitive decline. Conclusions: Apraxia profile evaluation could contribute to the differentiation between AD and Frontotemporal Dementia (FTD). Both TULIA and ABA-2 are reliable tools that can be performed as bed-side tests in clinical practice.
Seroprevalence Study of Anti-HBs Antibodies in the General Population of Vojvodina, Serbia
Authors: Rajčević Smiljana , Medić Snežana , Patić Aleksandra , Dragnić Nataša , Ristić Mioljub , Vuković Vladimir , Petrović Vladimir
Published: March 2024

Background and Objectives: Hepatitis B (HB) is a major global health problem and a potentially life-threatening disease caused by the hepatitis B virus (HBV). Also, it is an important cause of morbidity and mortality worldwide. Thanks to serological surveys, testing hepatitis B surface antibodies (anti-HBs) allows for serological assessments of their prevalence. The presence of anti-HBs, which protects against HBV infection, can be attributed to HB vaccination or natural HBV infection. The aim of our study was to evaluate the prevalence of HB surface antibodies (anti-HBs) as an indicator of collective immunity against HBV in the general population of the Autonomous Province of Vojvodina, Serbia. In addition, to distinguish whether anti-HBs were induced by the vaccine or by infection, the presence of antibodies against the hepatitis B core antigen (anti-HBc) was tested among those who were anti-HBs-positive. Materials and Methods: A total of 3467 residual sera samples, collected according to the specifications of the European Sero-Epidemiology Network 2 (ESEN2) study, from April 2015 to March 2016, were screened for the presence of anti-HBs using a chemiluminescence immunoassay. The difference between categorical variables was tested using the chi-square test. Results: Overall, 1870 (53.9%, 95% CI: 52.3–55.6) participants tested positive for anti-HBs. The median age of the study participants was 17 years (IQR 9–35). The anti-HB seroprevalence decreased with age, ranging from 80.7% (95% CI: 78.9–82.4) in the 1–19-year-old group to 16.4% (95% CI: 12.0–20.9) in the ≥60 years’ age group. A total of 71 (3.8%, 95% CI: 2.9–4.7) serum samples were also anti-HBc-positive. Higher prevalence, but not statistically significant, was noticed in women (4.1%, 95% CI: 2.8–5.4) compared with men (3.5, 95% CI: 2.4–4.8) (p = 0.542). Also, there was a significant difference across the age groups, where those ≥60 years old had a prevalence of 65.9% (95% CI: 51.9–79.9) and the age category of 1–19-year-olds had just 0.2% (95% CI: 0.0–0.4) (p < 0.001). Conclusions: This study provides a comprehensive assessment of the anti-HBs seroprevalence of the general population in Vojvodina and provides an opportunity to better shape the national preventive strategy related to HBV.
Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease
Authors: Rafaqat Saira , Gluscevic Sanja , Mercantepe Filiz , Rafaqat Sana , Klisic Aleksandra
Published: March 2024

Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment.
Synthesis and Biological Evaluation of New Dihydrofuro[3,2-b]piperidine Derivatives as Potent α-Glucosidase Inhibitors
Authors: Wang Haibo , Huang Xiaojiang , Pan Yang , Zhang Guoqing , Tang Senling , Shao Huawu , Jiao Wei
Published: March 2024

Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-b]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds 32 (IC50 = 0.07 μM) and 28 (IC50 = 0.5 μM) showed significantly stronger inhibitory potency against α-glucosidase than positive control acarbose. The study of the structure–activity relationship of these compounds provides a new clue for the development of new α-glucosidase inhibitors.
Electrocatalytic Degradation of Phenolic Wastewater Using a Zero-Gap Flow-Through Reactor Coupled with a 3D Ti/RuO2-TiO2@Pt Electrode
Authors: Zhu Yunqing , Wen Kaiyue , Li Bingqing , Hao Yirong , Zhou Jianjun
Published: March 2024

In this study, the performance of a zero-gap flow-through reactor with three-dimensional (3D) porous Ti/RuO2-TiO2@Pt anodes was systematically investigated for the electrocatalytic oxidation of phenolic wastewater, considering phenol and 4-nitrophenol (4-NP) as the target pollutants. The optimum parameters for the electrochemical oxidation of phenol and 4-NP were examined. For phenol degradation, at an initial concentration of 50 mg/L, initial pH of 7, NaCl concentration of 10.0 g/L, current density of 10 mA/cm2, and retention time of 30 min, the degradation efficiency achieved was 95.05%, with an energy consumption of 15.39 kWh/kg; meanwhile, for 4-NP, the degradation efficiency was 98.42% and energy consumption was 19.21 kWh/kg (at an initial concentration of 40 mg/L, initial pH of 3, NaCl concentration of 10.0 g/L, current density of 10 mA/cm2, and retention time of 30 min). The electrocatalytic oxidation of phenol and 4-NP conformed to the pseudo-first-order kinetics model, and the k values were 0.2562 min−1 and 0.1736 min−1, respectively, which are 1.7 and 3.6-times higher than those of a conventional electrolyzer. Liquid chromatography–mass spectrometry (LC–MS) was used to verify the intermediates formed during the degradation of phenol or 4-NP and a possible degradation pathway was provided. The extremely narrow electrode distance and the flow-through configuration of the zero-gap flow-through reactor were thought to be essential for its lower energy consumption and higher mass transfer efficiency. The zero-gap flow-through reactor with a novel 3D porous Ti/RuO2-TiO2@Pt electrode is a superior alternative for the treatment of industrial wastewater.
Rational Prescribing of Pancreatic Enzymes for Patients with Pancreatic Cancer
Authors: Garcia Mary Acelle G. , Imam Syed , Braun Ursula K. , Jackson Leanne K.
Published: March 2024

Most patients with pancreatic cancer at some point present with symptoms related to exocrine pancreatic insufficiency (EPI). These include diarrhea, abdominal bloating, indigestion, steatorrhea, weight loss, and anorexia. Even though up to 80% of pancreatic cancer patients eventually present with symptoms related to exocrine pancreatic insufficiency, only 21% are prescribed pancreatic enzyme replacement therapy (PERT). Its effectiveness is also highly dependent on its proper timing of administration, and patients must be thoroughly educated about this. The impact of symptoms of EPI can lead to poorer overall well-being. Pharmacists play a crucial role in properly educating patients on the correct use of pancreatic enzyme replacement therapy. PERT is a key strategy in managing the symptoms of EPI and can improve quality of life, which is a central focus in palliative care. This treatment is profoundly underutilized in the palliative care of these patients. The objective of this review is to discuss the pharmacology, pharmacokinetics, side effects, available evidence of the effectiveness of pancreatic enzyme use for patients with pancreatic cancer, and challenges, along with proposed solutions regarding its use.
Three-Dimension Calculation for the Scattering Problem for Non-Spherical Potential
Authors: Krassovitskiy Pavel M. , Pen’kov Fedor M.
Published: March 2024

The interaction of the 238U with a neutron is studied. Correct accounting for the non-spherical shape of the uranium nucleus is in focus. The optical potential is used as a model. It is shown that the spherically symmetric and non-spherical potentials give different scattering patterns, in particular different resonance features of the cross-section. The possibility of using the method as an extension of the particle–rotor model of the nucleus is illustrated.
Electric Octupole-Dependent Contributions to Optical Binding Energy
Authors: Salam A.
Published: March 2024

Contributions to the radiation-induced dispersion energy shift between two interacting particles dependent on the electric octupole moment are calculated using a physical picture in which moments induced by applied fluctuating electromagnetic fields are coupled via retarded interaction tensors. The specific potentials evaluated include those found between an electric dipole-polarisable molecule and either a mixed electric dipole–octupole- or purely octupole-polarisable molecule, and those between two mixed electric dipole–octupole-polarisable molecules. Interaction energies are obtained for molecular and pair orientationally averaged situations. Terms dependent on the octupole weight-1 moment may be viewed as higher-order corrections to the leading dipole–dipole interaction energy as also found in energy transfer and dispersion forces. A comprehensive polarisation analysis is carried out for linearly and circularly polarised laser light incident parallel and perpendicular to the inter-particle axis. Contributions to the optical binding energy arising when one of the pair is polar and characterised by either a permanent electric dipole or octupole moment are also evaluated. Neither of these energy shifts survive orientational averaging.
Effect of Light Quality on Seed Potato (Solanum tuberose L.) Tuberization When Aeroponically Grown in a Controlled Greenhouse
Authors: Rahman Md Hafizur , Islam Md. Jahirul , Mumu Umma Habiba , Ryu Byeong Ryeol , Lim Jung-Dae , Azad Md Obyedul Kalam , Cheong Eun Ju , Lim Young-Seok
Published: March 2024

A plant factory equipped with artificial lights is a comparatively new concept when growing seed potatoes (Solanum tuberosum L.) for minituber production. The shortage of disease-free potato seed tubers is a key challenge to producing quality potatoes. Quality seed tuber production all year round in a controlled environment under an artificial light condition was the main purpose of this study. The present study was conducted in a plant factory to investigate the effects of distinct spectrum compositions of LEDs on potato tuberization when grown in an aeroponic system. The study was equipped with eight LED light combinations: L1 = red: blue: green (70 + 25 + 5), L2 = red: blue: green (70 + 20 + 10), L3 = red: blue: green (70 + 15 + 15), L4 = red: blue: green (70 + 10 + 20), L5 = red: blue: far-red (70 + 25 + 5), L6 = red: blue: far-red (70 + 20 + 10), L7 = red: blue: far-red (70 + 15 + 15), L8 = red: blue: far-red (70 + 10 + 20), and L9 = natural light with 300 µmol m−2 s−1 of irradiance, 16/8 h day/night, 65% relative humidity, while natural light was used as the control treatment. According to the findings, treatment L4 recorded a higher tuber number (31/plant), tuber size (>3 g); (9.26 ± 3.01), and GA3 content, along with better plant growth characteristics. Moreover, treatment L4 recorded a significantly increased trend in the stem diameter (11.08 ± 0.25), leaf number (25.32 ± 1.2), leaf width (19 ± 0.81), root length (49 ± 2.1), and stolon length (49.62 ± 2.05) compared to the control (L9). However, the L9 treatment showed the best performance in plant fresh weight (67.16 ± 4.06 g) and plant dry weight (4.46 ± 0.08 g). In addition, photosynthetic pigments (Chl a) (0.096 ± 0.00 mg g−1, 0.093 ± 0.00 mg g−1) were found to be the highest in the L1 and L2 treatments, respectively. However, Chl b and TCL recorded the best results in treatment L4. Finally, with consideration of the plant growth and tuber yield performance, treatment L4 was found to have the best spectral composition to grow quality seed potato tubers.
Microanatomical Changes in the Leaves of Arundo donax (L.) Caused by Potentially Toxic Elements from Municipal Sewage Sediment
Authors: Tóth Csilla , Simon László , Tóth Brigitta
Published: March 2024

An open-field 3-year-long microplot experiment was set up with three micropropagated lines (SC Blossom, BFT Indiana, and STM Hajdúsági) of giant reed (Arundo donax L.). Plants were grown on a soil cover of a former sewage settling pond located in Debrecen Lovász-Zug, Hungary. Soil cover of the sewage sediment was moderately contaminated with various toxic elements (As, Ba, Cd, Cr, Cu, Mn, Ni, Pb, and Zn). The highest total concentration of examined toxic elements in leaves was found in the BFT Indiana line (∑326 mg/kg), while in the SC Blossom and STM Hajdúsági lines, ∑210 mg/kg and ∑182 mg/kg were measured, respectively. The highest Zn concentration (117 mg/kg) was found in the leaves of in BFT Indiana line and was 67% higher than that in SC Blossom and 95% more than in the STM Hajdúsági line. The BFT Indiana leaves showed typical signs of adaptation to heavy metal stress in the case of numerous micromorphometric characteristics. The extent of leaf mesophylls decreased, and the number of bulliform cells and phytoliths, as well as the sclerenchymatous stock, increased. The size of the vascular bundles was reduced. The size of the stomata decreased while the stomatal density increased. It can be concluded that the BFT Indiana line had the best adaptational response to heavy metal stress.
Rhynchotalona latens (Sarmaja-Korjonen, Hakojärvi et Korhola 2000) (Crustacea, Anomopoda, Chydoridae) in Lacustrine Sediments of European Russia
Authors: Ibragimova Aisylu G. , Gusarov Artyom V. , Frolova Larisa A.
Published: March 2024

Remains of Rhynchotalona latens (Sarmaja-Korjonen, Hakojärvi et Korhola 2000) were found in the bottom sediments of several glaciogenic lakes in northwestern Russia. Subfossil remains of the species were noted both in the bottom sediments of the Late Pleistocene and Mid-Holocene. We discovered a rare species, R. latens, in the bottom sediments of Lake Medvedevskoye (Karelian Isthmus). This species prefers shallow oligo-mesotrophic lakes with organic sediments and has attracted the interest of scientists around the world as it is considered a glacial relict and has recently been found in surface sediments and as a living population in Finland and Russia.
The Religious Which Is Political: Revisiting Pnina Werbner’s Imagined Diasporas and Beyond
Authors: Liebelt Claudia
Published: March 2024

Dedicated to the memory of Pnina Werbner, this essay revisits Werbner’s ethnographic and conceptual work on the relationship between diaspora and religion through a close reading of her book on Imagined Diasporas among Manchester Muslims and her later engagements with the concept of diaspora with respect to religion and the background of her work on African and Filipino labour diasporas in the West. It argues that many of Werbner’s insights remain pertinent today, not least because in many European contexts Muslim-background citizens and non-citizens remain excluded from full belonging and are still forced to engage in constant perspectival manoeuvring similar to Werbner’s earlier interlocutors. While the notion of diaspora has lost much of its earlier conceptual verve, in its Werbnerian reading, I argue, it may still offer a scholarly tool for analysing the multiple imaginations, belongings, and ambiguities of migrants’ and religious minorities’ self-representations and complex lives.
Syncretism in Miao Healing: Bridging Shamanic Practices and Scientific Treatments with Religion, Ritual, and Local Knowledge
Authors: Chen Zhengfu
Published: March 2024

The Miao (Hmong) community in Southwest China, deeply entrenched in a religious belief system acknowledging the omnipresent spiritual essence and venerating ancestor worship, perceives life as a harmonious blend of the “soul” and the “body”, intricately interwoven and mutually reinforcing. Within this cultural milieu, shamanism and healing practices form an inseparable nexus, epitomizing a worldview characterized by the harmonious coexistence of gods, spirits, ancestors, ghosts, and shamans. This study scrutinizes the syncretism employed by the Miao to address illness, bridging shamanic practices and scientific treatments with religion, ritual, and local knowledge. Through methodologies such as autoethnography, participant observation, and in-depth interviews, the research explores a Miao woman’s healing journey, synthesizing shamanic traditions with scientific interventions to reveal the nuanced interplay between traditional customs, environmental influences, and health beliefs. Despite encountering challenges like limited healthcare access and high costs, numerous Miao people seek assistance from shamans, underscoring the community’s resilience in navigating the intricate interrelationship between traditional practices and modern healthcare systems. By emphasizing the significance of syncretism, this study contributes to a nuanced understanding of how the Miao seamlessly integrate shamanic practices with scientific treatments, fostering improved intercultural communication and cultivating culturally sensitive healthcare practices, ultimately enhancing the overall well-being of the Miao community.
Anterior Uveitis Secondary to Avelumab and Pembrolizumab in a Patient with Metastatic Renal Cell Carcinoma—A Case Report
Authors: Chu Wei-Lun , Cheng Kai-Chun , Liu Pei-Kang , Lai Hung-Chi , Chen Kuo-Jen , Chang Yo-Chen
Published: March 2024

We present an unusual case of uveitis secondary to avelumab and pembrolizumab in a 39-year-old Taiwanese male with stage IV clear cell renal cell carcinoma (ccRCC) and lung metastasis, who initially received pembrolizumab as his primary treatment. However, the patient experienced skin and liver immune-related adverse events (irAEs) after the seventh dose of pembrolizumab, which prompted a switch to avelumab. The patient began to experience gradual blurring of vision after completing the fifth cycle of avelumab immunotherapy. Ophthalmic examinations revealed findings consistent with bilateral anterior uveitis. Despite an initial lack of significant improvement with steroid treatment, the patient’s vision and inflammation improved upon discontinuation of avelumab. Due to the occurrence of uveitis, avelumab was switched back to pembrolizumab. However, three months after initiating pembrolizumab, the patient developed foggy vision and bilateral anterior uveitis with cystoid macular edema (CME). The administration of topical, oral, and subconjunctival steroids resulted in an improvement in vision and the resolution of CME, without the need to discontinue pembrolizumab. Over the subsequent eighteen months, there has been no recurrence of uveitis, and there is no evidence of relapse or further metastasis in his ccRCC.
Cumulative Histograms under Uncertainty: An Application to Dose–Volume Histograms in Radiotherapy Treatment Planning
Authors: Gesualdi Flavia , Wahl Niklas
Published: March 2024

In radiotherapy treatment planning, the absorbed doses are subject to executional and preparational errors, which propagate to plan quality metrics. Accurately quantifying these uncertainties is imperative for improved treatment outcomes. One approach, analytical probabilistic modeling (APM), presents a highly computationally efficient method. This study evaluates the empirical distribution of dose–volume histogram points (a typical plan metric) derived from Monte Carlo sampling to quantify the accuracy of modeling uncertainties under different distribution assumptions, including Gaussian, log-normal, four-parameter beta, gamma, and Gumbel distributions. Since APM necessitates the bivariate cumulative distribution functions, this investigation also delves into approximations using a Gaussian or an Ali–Mikhail–Haq Copula. The evaluations are performed in a one-dimensional simulated geometry and on patient data for a lung case. Our findings suggest that employing a beta distribution offers improved modeling accuracy compared to a normal distribution. Moreover, the multivariate Gaussian model outperforms the Copula models in patient data. This investigation highlights the significance of appropriate statistical distribution selection in advancing the accuracy of uncertainty modeling in radiotherapy treatment planning, extending an understanding of the analytical probabilistic modeling capacities in this crucial medical domain.
Residence Layout Examined and Optimized by Sunshine: A Comparative Study between Barcelona and Northern Chinese Cities
Authors: Zhang Yunan , Chen Wenxuan , Yang Zhiqi , Liu Yingjie , Tang Zhipeng
Published: March 2024

This article compares the differences and similarities in residential layout and scale between Barcelona, Spain and Tianjin, a northern Chinese city, using Ladybug. We obtained sunshine simulation results under the same conditions in terms of building façades, lower floors, streets, courtyards and other aspects in two cities. Based on this, this paper draws on the advantages and disadvantages of the dense street network in the Eixample district of Barcelona and provides suggestions for the residential layout of cities in northern China. The aim of this study is to improve the residential layout of cities in northern China, while meeting the requirements of plot ratio and taking into account the favorable sunshine conditions in Barcelona. A key aspect of this study is the emphasis on the importance of capturing sunlight in future urban designs. Specifically, it highlights the potential for installing solar panels in areas with effective sunlight exposure of more than three hours daily such as streets, façades, rooftops and courtyards to harness solar energy and conserve resources. This paper compares the similarities and differences between the residence layout and scale in Barcelona, Spain and northern Chinese cities, regarding the overall façade of the building, the lower part of the building, and the streets and courtyards of the two coastal cities by using Ladybug to obtain sunshine simulation results under the same conditions and drawing lessons from the small block, dense street network of Barcelona’s Eixample district so as to put forward suggestions for the residential layout of northern Chinese cities. Research has found that the layout form of Barcelona housing is similar to the plot ratio of point and panel residential buildings in northern Chinese cities and has better hygiene conditions such as sunshine.
Electric Trolley Prototype for Goods and People Transport on Ziplines
Authors: Bianco Ettore , Giannuzzi Claudio , Corredor Pablos Andrés Felipe , Peña Reyes Vicente Alfredo , Berti Polato Davide
Published: March 2024

The increasing demand for efficient and cost-effective transportation solutions has led to the exploration of unconventional modes of transportation, such as ziplines. This paper presents the development of an electric prototype for a trolley that can be used for the simultaneous transport of goods and people on ziplines. The prototype is designed with a modular system that allows for easy customization based on the cargo’s weight and size. Two lightweight Maxon motors have been integrated for traction purposes with two Maxon inverters and a low-voltage swappable battery pack. The trolley’s chassis is made of lightweight materials, such as aluminum, making it highly maneuverable and capable of traveling at high speeds. The lightweight permits the operators to detach the trolley from the zipline when needed. The prototype’s traction and braking systems are controlled through a user-friendly interface, making it easy to operate, and with the possibility of a robust and automatic routine for goods transport. In this article, we present the simulation for the design and testing of the prototype, as well as its potential applications in various industries, such as mining, agriculture, and emergency services. Our results show that the prototype is a viable solution for zipline-based transportation, with high efficiency and performance standards. Further research and development are being conducted to optimize the prototype’s performance and expand its applications.
GP access for inclusion health groups: perspectives and recommendations
Authors: Verity Aaminah , Tzortziou Brown Victoria
Published: March 2024

Background

General practice has seen the widespread adoption of remote consulting and triage systems. There is a lack of evidence exploring how inclusion health populations have been impacted by this transformation.

Aim

This study aimed to explore the post-pandemic GP access for inclusion health populations, through the lens of those with lived experience, and identify practical recommendations for improving access for this population.

Design & setting

A mixed-methods study exploring the direct experience of people from inclusion health groups trying to access GP care in 13 practices in east London.

Method

A mystery shopper exercise involving 39 in-person practice visits and 13 phone calls were undertaken. The findings were reflected on by a multidisciplinary stakeholder group, which identified recommendations for improvements.

Results

Only 31% of the mystery shopper visits (
n
= 8) resulted in registration and the offer of an appointment to see a GP for an urgent problem. None of the mystery shoppers was able to book an appointment over the phone but
n
= 10/13 felt that they would be able to register and make an appointment if they followed the receptionist's instructions. Most mystery shoppers felt respected, listened to, and understood the information provided to them. Just under half of the practices (46%,
n
= 6) received positive comments on how accessible and supportive their spaces felt. Practice- and system-level recommendations were identified by the stakeholder group.

Conclusion

Ongoing GP access issues persist for inclusion health populations. We identified practice- and system-level recommendations for improving access for this vulnerable population.
A comparative study of Filon-type rules for oscillatory integrals
Authors: Majidian Hassan
Published: March 2024

Our aim is to answer the following question: "Among the Filon-type methods for computing oscillatory integrals, which one is the most efficient in practice?". We first discuss why we should seek the answer among the family of Filon-Clenshaw-Curtis rules. A theoretical analysis accompanied by a set of numerical experiments reveals that the plain Filon-Clenshaw-Curtis rules reach a given accuracy faster than the (adaptive) extended Filon-Clenshaw-Curtis rules. The comparison is based on the CPU run-time for certain wave numbers (medium and large).
Clinical Manifestations Laboratory Tests Abdominal Ultrasonic Findings and In-hospital Prognosis of COVID-19 in 185 Pediatric Cases in a Tertiary Center
Authors: Jafari Maryam , Mahalati Yasaman , Zarei Elham , Kazemi Mohammad Mahdi , Irompour Arsalan , Sadri Amirhoessein , AzadiYekta Hamed
Published: March 2024

Background: Despite the COVID-19 pandemic, there is little information about the different clinical aspects of COVID-19 in children. In this study, we assessed the clinical manifestations, outcome, ultrasound, and laboratory findings of pediatric COVID-19. Methods: This retrospective study was conducted on 185 children with definitive diagnosis of COVID-19 between 2021 and 2022. The patients’ information was retrieved from hospital records. Results: The average age of the patients was 5.18 ± 4.55 years, and 61.1% were male. The most frequent clinical manifestation was fever (81.1%) followed by cough (31.9%), vomiting (20.0%), and diarrhea (20.0%). Mesenteric lymphadenitis was common on ultrasound and found in 60% of cases. In-hospital death was identified in 3.8% of cases. The mean length of hospital stay was 8.5 days. Mandating intensive care unit (ICU) stay was found in 19.5% and 5.9% of cases were intubated. Acute respiratory distress syndrome (ARDS), lower arterial oxygen saturation, higher white blood cell (WBC) count, and higher C-reactive protein (CRP) were the main determinants of death. Lower age, respiratory distress, early onset of clinical manifestations, lower arterial oxygen saturation, lower serum hemoglobin (Hb) level, and higher CRP level could predict requiring ICU admission. Conclusion: We recommend close monitoring on CRP, serum Hb level, WBC count, and arterial level of oxygenation as clinical indicators for potential progression to critical illness and severe disease. Mesenteric lymphadenitis is a common sonographic finding in pediatric COVID-19 which can cause abdominal pain. Ultrasound is helpful to avoid unnecessary surgical interventions in COVID-19.
Prevalence and Risk Factors for Suicidal Ideation Following the COVID-19 Pandemic in Kerman Province: A Cross-Sectional Study
Authors: Pouradeli Shiva , Ahmadinia Hassan , Rezaeian Mohsen
Published: March 2024

Background: Suicidal ideation (SI) serves as an important predictor of suicide. The prevalence of SI has increased following the COVID-19 pandemic. This study aims to investigate the prevalence and risk factors associated with SI after the pandemic in the Kerman province. Methods: This cross-sectional study was conducted in 23 counties of the Kerman province between 2021 and 2022. The Beck Scale for Suicidal Ideation (BSSI) was utilized to estimate SI, while multiple logistic regression analysis was employed to examine the impact of various variables on SI. Results: A total of 1421 individuals (47.7% men, 50.0% women and 2.3% unknown) with an average age of 35.17±9.47 years participated in this study. The estimated prevalence rate of SI was 9.2%, with variations ranging from 0% to 42% across different counties. Individuals with SI exhibited a significantly younger mean age and fewer family members. Furthermore, SI was significantly more prevalent among single participants, unemployed individuals, students, those with a history of mental illness, prior psychiatric medication use, and previous SI. Employed individuals had 87% lower odds of experiencing SI compared to the unemployed. Individuals with a history of prior SI had 239 times higher odds of SI than those without such a history. Additionally, each year increase in age corresponded to an 8.8% decrease in the odds of SI. Conclusion: The high prevalence of SI is concerning, and it is essential to remain vigilant regarding its health and social consequences as the pandemic continues. Therefore, it is imperative to provide enhanced mental health services, particularly targeting at-risk groups.
Iron, Copper, and Magnesium Concentration in Hair and Risk of Esophageal Cancer: A Nested Case-Control Study
Authors: Hashemian Maryam , Poustchi Hossein , Sharafkhah Maryam , Pourshams Akram , Mohammadi-Nasrabadi Fatemeh , Hekmatdoost Azita , Malekzadeh Reza
Published: March 2024

Background: An association has already been hypothesized between iron, copper, and magnesium status assessed through food frequency questionnaires (FFQs) and the risk of esophageal squamous cell carcinoma (ESCC). However, self-reported dietary assessment methods are prone to measurement errors. We studied the association between iron, copper, and magnesium status and ESCC risk, using hair samples as a long exposure biomarker. Methods: We designed a nested case-control study within the Golestan Cohort Study, that recruited about 50000 participants in 2004-2008, and collected biospecimens at baseline. We identified 96 incident cases of ESCC with available hair samples. They were age-matched with cancer-free controls from the cohort. We used inductively coupled plasma mass spectrometry (ICP-MS) to measure iron, copper, and magnesium concentrations in hair samples. We used multiple logistic regression models to determine odds ratios and 95% confidence intervals. Results: Median concentrations of iron, copper, and magnesium were 35.4, 19.3, and 41.7 ppm in cases and 25.8, 18.3, and 50.0 ppm in controls, respectively. Iron was significantly associated with the risk of ESCC in continuous analysis (OR=1.41, 95% CI=1.03-1.92), but not in the tertiles analyses (ORT3 vs. T1=1.81, 95% CI=0.77-4.28). No associations were observed between copper and magnesium and ESCC risk, in either the tertiles models or the continuous estimate (copper: ORT3 vs. T1=2.56, 95% CI=1.00-6.54; magnesium: ORT3 vs. T1=0.75, 95% CI=0.32-1.78). Conclusion: Higher iron status may be related to a higher risk of ESCC in this population.
Clinicopathological Features of Hereditary Nephritis in the Iranian Population: Analysis of a 14-Year Survey in Kidney Biopsies From a Large Referral Center
Authors: Emami Amir , Nili Fatemeh , Sotoudeh Anvari Maryam , Salarvand Samaneh , Seirafi Golnar
Published: March 2024

Background: Hereditary nephritis (HN), including Alport syndrome (AS) and thin basement membrane nephropathy (TBMN), is a rare genetic cause of hematuria. A definitive diagnosis requires electron microscopy (EM). Therefore, the clinical characteristics of these conditions are less known. This study aimed to determine the percentage and clinicopathological features of HN in patients from a referral center in Iran. Methods: We checked kidney biopsy reports from 2007 to 2021 and extracted cases with HN. Fresh specimens of the cases diagnosed in the last two years were stained by immunofluorescence (IF) for collagen type IV alpha chains. EM findings in these cases were re-evaluated and categorized as diffuse glomerular basement membrane (GBM) thinning, definite, and suspicious features of AS. Results: We analyzed 3884 pathology reports of kidney biopsies from 2007 to 2021 and identified 210 patients (5.4%) with HN, with a mean age of 13.78±12.42 years old. Hematuria with proteinuria (53.3%), isolated hematuria (44.2%), and proteinuria with hematuria and increased creatinine (2.5%) were found in these patients. The re-evaluation of EM findings revealed GBM thinning, definite, and suspicious findings of AS in 37.5%, 43.8%, and 18.8% cases, respectively. The most common diagnosis in 32 cases after the IF study was X-linked AS (71.9%), and 6.2% of cases were autosomal recessive AS. TBMN and autosomal dominant AS remained the differential diagnoses in 21.9%. Conclusion: It was found that EM is helpful for the primary diagnosis of patients with definite AS. Immunostaining improves the diagnostic sensitivity for the differentiation of those with suspicious EM findings and determines the inheritance pattern. However, a multidisciplinary approach for a subset of cases is required for the best diagnosis and management.