bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of obstructive sleep apnea on glucose metabolism
Authors: Koh Han-Chow E , van Vliet Stephan , Cao Chao , Patterson Bruce W , Reeds Dominic N , Laforest Richard , Gropler Robert J , Ju Yo-El S , Mittendorfer Bettina
Published: February 2022

Background

Obstructive sleep apnea (OSA) is prevalent in people with obesity and is a major risk factor for type 2 diabetes (T2D). The effect of OSA on metabolic function and the precise mechanisms (insulin resistance, β-cell dysfunction, or both) responsible for the increased T2D risk in people with OSA are unknown.

Design and methods

We used a two-stage hyperinsulinemic–euglycemic clamp procedure in conjunction with stable isotopically labeled glucose and palmitate tracer infusions and 18F-fluorodeoxyglucose injection and positron emission tomography to quantify multi-organ insulin action and oral and intravenous tolerance tests to evaluate glucose-stimulated insulin secretion in fifteen people with obesity and OSA and thirteen people with obesity without OSA.

Results

OSA was associated with marked insulin resistance of adipose tissue triglyceride lipolysis and glucose uptake into both skeletal muscles and adipose tissue, whereas there was no significant difference between the OSA and control groups in insulin action on endogenous glucose production, basal insulin secretion, and glucose-stimulated insulin secretion during both intravenous and oral glucose tolerance tests.

Conclusions

These data demonstrate that OSA is a key determinant of insulin sensitivity in people with obesity and underscore the importance of taking OSA status into account when evaluating metabolic function in people with obesity. These findings may also have important clinical implications because disease progression and the risk of diabetes-related complications vary by T2D subtype (i.e. severe insulin resistance vs insulin deficiency). People with OSA may benefit most from the targeted treatment of peripheral insulin resistance and early screening for complications associated with peripheral insulin resistance.
Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads
Authors: Piprek Rafal P , Rams-Pociecha Izabela , Zdanowski Robert , Kloc Malgorzata , Kubiak Jacek Z
Published: February 2022

Cell to cell interactions are crucial for morphogenesis and tissue formation. Desmoplakin (encoded by the Dsp gene) is a component of desmosomes and anchors the transmembrane adhesion proteins to the cytoskeleton. Its role in gonad development remains vague. To study the role of desmoplakin in gonad development, we used a tissue-specific knockout of the Dsp gene in the NR5A1+ somatic cells of the gonads. We show here that desmoplakin is necessary for the survival of germ cells in fetal testes and ovaries. The Dspknockout in NR5A1+ somatic cells in testes decreased the number of germ cells, and thus the size of the testes, but did not affect the Sertoli cells or the structure of testis cords and interstitium. The Dspknockout in NR5A1+ somatic cells in ovaries decreased the number of female germ cells and drastically reduced the formation of ovarian follicles. Dsp knockout in NR5A1+ somatic cells did not affect the sex determination and sexual differentiation of the gonads, as judged from an unchanged expression of genes essential for these processes. We conclude that mediation by desmoplakin cell adhesion between the gonadal cells is necessary for germ cell survival.
When Your Mentee Is Denied Tenure: Reflections on Lorgia García-Peña’s Work
Authors: Guidotti-Hernández Nicole M.
Published: February 2022

This essay examines the role of hate crimes, structural racism, and the lack of transparency in Harvard’s denial of Lorgia García-Peña’s tenure case. As a rebuttal to the lack of explanation for why the decision was made, the essay analyzes the deep impact of García-Peña’s scholarship on a global scale.
Dostęp naczyniowy typu midline. Nowe możliwości obecnych kompetencji
Authors: Latos Maciej
Published: February 2022

Częste i wielotygodniowe hospitalizacje, implikujące wielokrotne próby kaniulacji, powodują, że przybywa pacjentów z „trudnym dostępem naczyniowym”. Wskazaniem do cewnika pośredniego jest przewidywana terapia dożylna powyżej 6 dni, w sytuacji, w której pacjent nie wymaga cewnika centralnego. Cewniki pośrednie zakładane są do żył obwodowych ramienia. Strategia ich utrzymania opiera się na przestrzeganiu zasad antyseptyki, prawidłowej zmianie opatrunków oraz zachowaniu drożności cewnika. Z punktu widzenia obowiązujących przepisów prawa oraz posiadanych kompetencji identyfikacja naczyń pod kontrolą ultrasonograficzną i implantacja cewnika pośredniego mieści się w zakresie kwalifikacji zespołów pielęgniarskich.
Method for Representing an Exponent in a Fifth-dimensional Hypercomplex Number Systems Using a Hypercomplex Computing Software
Authors:   Institute for information recording NAS of Ukraine, Кalinovskiy Ya.А. , Boiarinova Yu.E. ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
Published: February 2022

The structure of method for constructing a representation of an exponential function in hypercomplex number systems (HNS) by the method of solving an associated system of linear differential equations is considered. Brief information about the hypercomplex computing software (HCS) is given. With the use of HCS, the necessary cumbersome operations on symbolic expressions were performed when constructing the representation of the exponent in the fifthdimensional HNS. Fragments of programs in the environment of HCS and results of symbolic calculations are resulted.
Mathematical Models of the Temperature Field in Heat-sensitive Elements of Electronic Devices
Authors:   Lviv Polytechnic National University, Havrysh V.I.
Published: February 2022

Nonlinear mathematical models for the analysis of temperature regimes in a thermosensitive isotropic plate heated by locally concentrated heat sources have been developed. For this purpose, the heat-active zones of the plate are described using the theory of generalized functions. Given this equation of thermal conductivity and boundary conditions contain discontinuous and singular right parts. The original nonlinear equations of thermal conductivity and nonlinear boundary conditions are linearized by Kirchhoff transformation. To solve the obtained boundary value problems, the integral Fourier transform was used and, as a result, their analytical solutions in the images were determined. The inverse integral Fourier transform was applied to these solutions, which made it possible to obtain analytical expressions for determining the Kirchhoff variable. As an example, the linear dependence of the thermal conductivity on temperature is chosen, which is often used in many practical problems. As a result, analytical relations were obtained to determine the temperature in the heat-sensitive plate. The given analytical solutions are presented in the form of improper convergent integrals. According to Newton’s method (three eighths), numerical values of these integrals are obtained with a certain accuracy for given values of plate thickness, spatial coordinates, specific power of heat sources, thermal conductivity of structural materials of the plate and geometric parameters of the heat-active zone. The material of the plate is silicon and germanium. To determine the numerical values of temperature in the structure, as well as the analysis of heat transfer processes in the middle of the plate due to local heating, developed software, using which geometric mapping of temperature distribution depending on spatial coordinates, thermal conductivity, specific heat flux density. The obtained numerical values of temperature testify to the correspondence of the developed mathematical models of the analysis of heat exchange processes in the thermosensitive plate with local heating to the real physical process.
Some Features of Imaginary Exponential Functions in Two-dimensional Noncommutative, Non-associative Algebraic Systems
Authors:   Private Joint Stock «National Power Company «UkrEnergo», Klipkov S.I.
Published: February 2022

Mathematical properties of imaginary exponential functions that can be used to represent the elements of two-dimensional algebraic systems constructed by introducing anticommutativity in the laws of composition of the elements of the basis of two-dimensional canonical numerical systems are considered.
Development of Methodical Recommendations Usage of Functional Paradigm Programming in Scala
Authors:   National Aviation University, Puchko I.V. , Prymushko A.M. ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Kravtsov H.O. ,   G.E. Pukhov Institute for Modelling in Energy Engineering National Academy of Sciences of Ukraine
Published: February 2022

Different approaches to defining data structures and creating programs in different ones are considered programming paradigms. The dependence of the imperative programming paradigm on low-level algorithms and operations. Ideas for the main variables of data structures are given and operations on their mutation. Approaches to the organization of algorithms in the programming language are described in Scala using these data structures. It is shown that in the declarative paradigm programming focus shifts from algorithms to mathematical expressions, and demonstrates how to use high – level operations to create a program for using algebraic expressions.
РОЗВ’ЯЗАННЯ ПЛОСКИХ ПРУЖНО-ПЛАСТИЧНИХ ЗАДАЧ В УМОВАХ СКЛАДНОГО НАВАНТАЖЕННЯ
Authors: Панін К. В.
Published: February 2022

Запропоновано числовий алгоритм розв’язання пружно-пластичних задач плоскої деформації та плоского напруженого стану для умов складного навантаження. Він базується на застосуванні методу скінченних елементів і диференціально-нелінійного варіанту теорії пластичності, що враховує мікродеформації (Новожилова, Кадашевича, Чернякова). Крайові задачі теорії пластичності зводяться до послідовності задач Коші, які розв’язуються за допомогою методу Ейлера з проміжними ітераціями. На кожному кроці методу Ейлера область напрямків активного мікропластичного деформування визначається методом простої ітерації.
Estratégias metodológicas para investigar a recepção de pessoas com deficiência intelectual
Authors: Berni Felipe Collar , Bianchi Graziela Soares
Published: February 2022

O texto traz a reflexão de natureza metodológica em relação aos estudos de recepção considerando pessoas com deficiência intelectual como público jornalístico. A partir de materialidade empírica, discute o emprego de métodos, técnicas e recursos para investigar o consumo de sujeitos com especificidades demarcadas. Considera-se a triangulação metodológica como perspectiva determinante para investigar os sentidos, conflitos e significados. São articulados recursos como história de vida, entrevista compreensiva, juntamente com adaptações nas estratégias para dar conta das medidas de distanciamento social em decorrência da COVID-19 assim, constitui o WhatsApp um espaço de troca e compartilhamento da rotina midiática, e adapta-se para o formato online o grupo focal.
Indonesia Digital Economic Diplomacy during the Covid-19 Global Pandemic
Authors: Triwahyuni Dewi
Published: February 2022

The study aims to optimize the use of Information Technology in Indonesian diplomacy during the COVID-19 pandemic, especially in the economic sector. To analyze this phenomenon, the research uses qualitative methods. The study is analytical descriptive by collecting detailed data from various sources of information, especially from multiple sources related to the object of this study. The research results concluded that Indonesia does not have a clear agenda or blueprint for using digital diplomacy. Because the use of information technology to publish policies during the COVID-19 pandemic is increasing, Indonesia must continue to learn from many countries in introducing the formulation of an economic digital diplomacy agenda from institutional adaptation to new approaches in foreign policy socialization through new media. This research will impact a more comprehensive digital diplomacy model for Indonesia.
Problematic online gambling among adolescents: A systematic review about prevalence and related measurement issues
Authors: Montiel Irene , Ortega-Barón Jéssica , Basterra-González Arantxa , González-Cabrera Joaquín , Machimbarrena Juan Manuel
Published: February 2022

Background and aims

Despite its illegality among adolescents, online gambling is a common practice, which puts their mental health and well-being at serious risk. This systematic review summarises international scientific literature from the last 20 years on problematic online gambling among adolescents (11–21 years old) to determine its prevalence and to analyse related measurement issues.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed and a protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, IC: CRD42020162932). Five academic databases were consulted, which resulted in an initial sample of 658 papers.

Results

Sixteen studies met the inclusion criteria for this review. All studies were cross-sectional and targeted students from elementary school, secondary school or university. Most followed a convenience sampling procedure. The primary measurement instruments used were the DSM-IV-MR-J and SOGS-RA. Between 0.77% and 57.5% of adolescents present some degree of problematic online gambling (problem, pathological or disordered) depending on the instruments used, the study samples and the timeframe analysed. Between 0.89% and 1% of adolescents exhibited an online gambling disorder.

Discussion and conclusion

There is a great heterogeneity in the methodology of the reviewed studies (samples, measurement instruments, cut-off points and criteria applied). The limited number of studies and the limited generalizability of their results suggest the need for further research and for development of specific instruments to assess different levels of problematic online gambling in representative samples of adolescents based on clinical ‘gold standard’ criteria and more accurate cut-off points.
The Middle Way in the Red Book and in the Buddha’s Quest
Authors: Ellis Robert M.
Published: February 2022

This uses the story of Jung’s encounter with Izdubar, the God figure who is reduced to an egg and then deliberately revived, to explore the potential of the Middle Way in relation to God in Jung’s experience, and compare it to the Middle Way discovered by the Buddha in the course of his quest for enlightenment.
Dropshipping pada CV. Karya Utama Surabaya terhadap Pemberdayaan Kaffahisme Ekonomi Perspektif Hukum Islam
Authors: Hidayatullah Hamdani Syarifuddin
Published: February 2022

This study examines the dropshipping activities carried out by CV. Karya Utama Surabaya in empowering economic kaffahism. This study uses a descriptive method with a qualitative approach. The collected data were analyzed using descriptive qualitative analysis method. The purpose of this study was to determine the implementation of dropshipping activities in empowering economic kaffahism and dropshipping practices with an Islamic perspective. The result of this research is the implementation of dropshipping has contributed to economic empowerment evenly. Dropship is allowed in Islam as long as there is no argument for prohibiting it by using the contract and its respective consequences such as the salam contract, wakalah and samsarah. The author suggests internet-based business and marketing players, in this case CV. Karya Utama Surabaya (supplier) and modern sales force (dropshipper). Among them, dropshippers are required to be able to provide the totality of services to anyone who is involved in the world of online buying and selling and marketing based on modern technology. Meanwhile, CV. Karya Utama Surabaya as a supplier must also be selective in choosing dropshippers who want to partner with the company.
Penggunaan Jaminan KSK dan Akta Nikah pada Pembiayaan Murabahah Bi al-Wakalah Perspektif Mashlahah al-Mursalah
Authors: Hizbayni Moh. Hamdan Hizbayni
Published: February 2022

This is a field research that aims to answer how the practice of using KSK guarantees and marriage contracts in murabahah al-mursalah financing and how to analyze mashlahah al-mursalah on the practice of using these guarantees. In practice at BMT Amana Madina, murabahah financing is equipped with a wakalah contract, in which the BMT represents the customer to make the purchase of the goods themselves and then the contract is carried out with the determination of the cost of purchase and profit margin in accordance with BMT policies accompanied by the use of collateral as a bond of trust between customers and financial institutions in the form of KSK marriage certificates. The aim are embracing customers and increasing economic equity in the middle to the lower economic community with a financing value of IDR 300,000 to IDR 1,500,000. The implementation of murabahah al-wakalah financing at BMT Amana Madina is in accordance with Islamic law because it has fulfilled the requirements contained in the murabahah and wakalah contracts. Regarding the use of KSK guarantees and marriage certificates in the financing, it is included in the muamalah field which does not have arguments that justify or prohibit it, but has many benefits, both for customers and BMT Amanah Madina. The benefits have met the requirements in the use of mashlahah al-mursalah. So that, the use of KSK guarantees and marriage certificates is included in the scope of mashlahah al-mursalah.
Analysis of Islamic Law and Law No. 56 PRP 1960 on the Practice of Pawning Paddy Fields in the Village of Malang
Authors: Musyarofah Hanik
Published: February 2022

This is field research entitled "Review of Islamic Law and Law Number 56 Prp of 1960 Against Pawn Pawn Practices in Jambesari Village, Poncokusumo District, Malang Regency". This study has two objectives, namely: how the practice of pawning rice fields in Jambesari Village, Poncokusumo District, Malang Regency and how to analyze Islamic law and Law no. 56 Prp Th. 1960 on the practice of pawning rice fields in Jambesari Village, Poncokusumo District, Malang Regency. The results of this study are that: first, the practice of pawning rice fields by the people of Jambesari Village, Poncokusumo District, Malang Regency is carried out by making an oral pawn agreement from both parties for a certain period; and second, the practice of pawning rice fields in Jambesari Village, Poncokusumo District, Malang Regency is in accordance with the opinion of the Hanafiyah scholars. However, contrary to the number of Maliki, Shafi'i and Hanbali scholars, it is mainly related to the use of pawned land which tends to have an element of coercion.
Some types of $f$-biharmonic and bi-$f$-harmonic curves
Authors: ERDOĞAN Feyza Esra , BOZDAĞ Şerife Nur
Published: February 2022

In this paper, we determine necessary and sufficient conditions for a non-Frenet Legendre curve to be $f$-harmonic, $f$-biharmonic, bi-$f$-harmonic, biminimal and $f$-biminimal in three-dimensional normal almost paracontact metric manifold. Besides, we obtain some nonexistence theorems.
Construction and validation of an observation tool of the imbalance pass in futsal
Authors: Alves Mylena Aparecida Rodrigues , Graça Daniel Cavalgante da , Travassos Bruno
Published: February 2022

Abstract This study aimed to construct a tool for observing the imbalance pass in futsal through Microsoft Excel® software and to establish its content validity and intra- and interobserver reliability based on the calculation of the content validity coefficient (CVC) and the intraclass correlation coefficient (ICC). For the construction of the tool, futsal specialists (n = 10) with an average age of 44.1 ± 12.34 years and 19 ± 7.21 years of experience in the field participated in the study. 60% of the specialists have international-level expertise and 50% are active in practice and in academic field (higher education professor). According to the methodology, 23 items were proposed to assess the imbalance pass in futsal. CVC was calculated based on language clarity, practical pertinence and theoretical relevance for each item of the instrument and for the instrument as a whole; ICC was calculated based on intra- and interobserver agreement. Language clarity, practical pertinence and theoretical relevance revealed a result of 0.92, 0.93 and 0.95, respectively, and the values for intra- and interobserver agreement reliability were excellent according to the literature (> 0.75). Thus, it is concluded that the items proposed in the tool obtained satisfactory psychometric properties.
Correlation between body composition data obtained by DXA and skinfold predictive protocols in sprinters
Authors: Lázari Evandro , Moraes Anderson Marques de , Alcântara Rafael Aoki de , Oliveira Rafael Luiz de , Gazzaneo Ricardo Montenegro
Published: February 2022

Abstract The aim of this study was to describe the correlation between body composition data obtained through DXA and through skinfolds strategy, with some of their respective formulas, in sprinters. The sample consisted of 15 male sprinters (23.81 years ± 3.11; 70.06 Kg ± 4.38; and 179.13 CM ± 5.16) all high performance runners of speed and barriers events (100m, 200m, 400m, 110m with barriers and 400m with barriers). The athletes were submitted to DXA evaluation procedure and to skinfolds collection (triceps, biceps, subscapular, supra iliac, abdominal, medial thigh and calf) and the results were calculated through four distinct equations: Slaughter, Faulkner, Lázari and Boileau. The respective DXA correlations (0.60; 0.81; 0.23 and 0.48) and the equations predicted by skinfold strategy were calculated using Pearson correlation. Among the equations used, Faulkner's was the one presenting highest correlation value when compared to DXA protocol, although all of them aimed to estimate values for BF%.
Knowledge and attitude about disabilities in leprosy: Effects of an intervention grounded on the Meaningful Learning Theory
Authors: Santana Emanuelle Malzac Freire de , Brito Karen Krystine Gonçalves de , Nóbrega Matheus de Medeiros , Antas Ester Missias Villaverde , Sousa Alana Tamar Oliveira de , Oliveira Simone Helena dos Santos
Published: February 2022

Abstract Objective: To analyze the effects of an educational intervention in the light of the Meaningful Learning Theory on the knowledge and attitude of Primary Health Care physicians and nurses in the assessment of the degree of physical disability in leprosy. Method: An intervention study of the before-and-after type, conducted with 122 professionals (84 nurses and 38 physicians) from the Primary Health Care of João Pessoa, Paraíba, in a training course on the assessment of the degree of physical disability in leprosy. The data were collected with the research’s own instrument validated and analyzed by the chi-square adherence and proportion test, with a 5% significance level. Results: There was an increase in the scores of all items of the instrument, with a statistically significant difference (p < 0.05) in 20 of the 32 items, with emphasis on those related to the professional’s technical ability to conduct the stages of anamnesis, palpation of peripheral nerves, sensory and motor evaluation. It is also noteworthy that, after the intervention, 5 items obtained 100% of correct answers. Conclusion: The educational intervention grounded on the Meaningful Learning Theory improved the health professionals’ knowledge and attitude in the assessment of the degree of physical disability in people with leprosy.
Clinical Frailty Scale em idosos atendidos no Serviço Hospitalar de Emergência: a fragilidade basal é um bom preditor de mortalidade em 90 dias?
Authors: Pinheiro Tatiana de Carvalho Espíndola , Alcântara Camila Oliveira , Pereira Fabiano Moraes , Andrade Marcus Vinícius Melo de , Moraes Edgar Nunes de , Bicalho Maria Aparecida Camargos
Published: February 2022

Resumo Objetivo Avaliar a capacidade da Clinical Frailty Scale (CFS) em predizer a mortalidade em até 90 dias e outros desfechos desfavoráveis em idosos admitidos em um Serviço Hospitalar de Emergência (SHE). Método Estudo de coorte prospectivo que incluiu idosos admitidos e que permaneceram por pelo menos uma noite no SHE de um hospital público terciário. O grau de fragilidade basal foi avaliado através da CFS e sua pontuação, o preditor estudado, por meio da curva Receiver Operator Characteristics (ROC). Analisou-se como desfecho primário a mortalidade em 90 dias. Considerou-se como desfechos secundários: mortalidade em 180 dias, declínio funcional, readmissão no SHE, reinternação e necessidade de atenção domiciliar. Resultados 206 participantes foram incluídos. Dos 127 idosos frágeis, 40 (31,5%) faleceram até o 90º dia comparado a 5 (6,3%) do grupo não frágil (p<0,001). Após ajuste para variáveis demográficas e clínicas, a fragilidade manteve-se no modelo como um preditor independente de mortalidade em 90 dias da admissão. A acurácia obtida pela curva ROC (AUROC) para predição de mortalidade em 90 dias foi de 0,81. Para mortalidade em 180 dias foi 0,80; para necessidade de atenção domiciliar, 0,77; e para reinternação, 0,65. Para os demais desfechos estudados, a acurácia não foi significativa. Conclusão A fragilidade basal medida pela CFS é um bom preditor de mortalidade em 90 e 180 dias e de necessidade de atenção domiciliar em idosos admitidos no SHE. Sua aplicação nesse cenário pode auxiliar na tomada de decisões clínicas.
Fatores associados à não adesão à farmacoterapia em pessoas idosas na atenção primária à saúde no Brasil: uma revisão sistemática
Authors: Silva William Lucas Ferreira da , Gomes Leonardo Campos , Silvério Marcelo Silva , Cruz Danielle Teles da
Published: February 2022

Resumo Objetivos Identificar os fatores associados à não adesão à farmacoterapia em pessoas idosas brasileiras no âmbito da atenção primária à saúde (APS) através da realização de uma revisão sistemática da literatura. Método Trata-se de uma revisão sistemática da literatura nos idiomas inglês, espanhol e português, realizada na biblioteca eletrônica SciELO e nas bases de dados eletrônicas MEDLINE - via PubMed, LILACS, Embase e Web of Science no período de janeiro de 2010 a junho de 2020. A seleção dos estudos foi realizada de maneira independente por dois revisores, por meio do aplicativo de seleção Rayyan. Resultados Após a aplicação dos critérios de elegibilidade, foram incluídos nove estudos na revisão sistemática. O principal método utilizado para mensurar o desfecho foi a Escala de Morisky-Green (4-itens). Os resultados apontam as dificuldades de acesso aos medicamentos, as multimorbidades, a polifarmácia, o uso de medicamentos potencialmente inapropriados para idosos, o grau de confiança no profissional médico, as crenças, a autopercepção de saúde negativa e a incapacidade funcional como os principais fatores associados à não adesão à farmacoterapia na APS. Conclusões No âmbito da APS, a não adesão à farmacoterapia pela população idosa se apresenta como um problema muito frequente, sendo desencadeado por múltiplos fatores e com consequências negativas para o controle das condições de saúde, para o uso racional de medicamentos e para um envelhecimento saudável. Destaca-se ainda que parte dos fatores associados são passíveis de intervenção nesse nível de atenção à saúde.
Associação da autopercepção da qualidade de vida e saúde, prática de atividade física e desempenho funcional entre idosos no interior do Brasil
Authors: Barbosa Renata da Costa , Sousa Ana Luiza Lima
Published: February 2022

Resumo Objetivo analisar a autopercepção de saúde e da qualidade de vida associados aos fatores contextuais em idosos não institucionalizados em município rural no interior do Brasil. Método Estudo transversal de base populacional. Foram incluídos indivíduos com 60 anos ou mais, não institucionalizados, residentes em município com características rurais. Foram utilizadas variáveis sociodemográficas, autopercepção da saúde e da qualidade de vida, nível de atividade física e desempenho funcional. Os dados foram coletados em domicílio com aplicação de entrevista e dos instrumentos: WHOQOL BREF, Questionário Internacional de Atividade Física (IPAQ) e teste Timed Up and Go (TUG). Para a análise de comparação e associação foram aplicados os testes qui-quadrado ou exato de Fisher e Razão de Prevalência (RP) e intervalos de confiança (IC). Resultados Participaram do estudo 142 idosos, sendo 58,5% do sexo feminino, com média de idade de 72,4 (±8,0) anos. A autopercepção da saúde foi associada à prática de atividade física (RP=1,13, IC=1,01-1,27) e ao desempenho funcional (RP=1,24, IC=1,03-1,48). A percepção da saúde (RP=1,66, IC=1,57-1,76) e qualidade de vida (RP=1,70, IC=1,60-1,79) boa/muito boa foi associada de forma positiva à prática de atividade física e independência funcional. Conclusão A prática de atividade física e a manutenção da independência funcional contribuem de forma significativa para uma percepção positiva da saúde e qualidade de vida. Porém, idosos insuficientemente ativos e independentes também podem ter boa percepção da saúde. Recomendam-se intervenções nas políticas públicas que considerem características intrínsecas de cada população visando manter ou melhorar a percepção de saúde e qualidade de vida dos idosos.
Noção de família(s) no campo da saúde brasileira: ensaio teórico-reflexivo
Authors: Campos Lucas Lima , Melo Anna Karynne
Published: February 2022

RESUMO Objetivo discutir o termo família no campo da saúde brasileira por meio: 1) do resgaste histórico do conceito e configuração da família no Brasil; 2) da recapitulação e problematização do termo na saúde brasileira; 3) da discussão na Política Nacional de Atenção Básica. Método trata-se de um estudo teórico-reflexivo. Resultado o texto foi dividido em: “Resgate histórico das transformações familiares no Brasil”, “Primeira Unidade Básica de Saúde: a família” e “Política Nacional de Atenção Básica: de que família estamos falando?”, que auxiliaram na argumentação sobre a problemática da (não)definição do termo família. Em meio a preocupação sobre alocar o cuidado voltado para a família, torna-se necessário repensar esse termo polissêmico, propondo a desnaturalização de definições cristalizadas que podem emergir na práxis dos profissionais, o que pode produzir atuações baseadas em (pré-)conceitos e negligências a famílias não hegemônicas. Considerações finais e implicações para a prática é necessário discutir sobre qual concepção de família é considerada no campo da saúde e suas repercussões, principalmente na Atenção Primária à Saúde e em políticas de saúde, como na Política Nacional de Atenção Básica, para minimizar possíveis dificuldades que possam surgir no fazer dos profissionais ao se deparar com a pluralidade das realidades familiares.
Whole-plant soybean ensiling with chitosan and homolactic microbial inoculant: fermentative profile, aerobic stability, and sheep intake and digestibility
Authors: Gandra Jefferson Rodrigues , Del Valle Tiago Antônio , Pause Alzira Gabriela da Silva , Pedrini Cibeli Almeida , Oliveira Euclides Reuter de , Goes Rafael Henrique de Tonissi e Buschinelli de , Oliveira Kelly Mari Pires de , Batista Jamille Débora de Oliveira , Antonio Giovani , Noia Isabelle Zocolaro , Acosta Anderson
Published: February 2022

ABSTRACT This study aimed to evaluate the effects of chitosan and homolactic microbial inoculant on fermentative losses, chemical composition, fermentative profile, and aerobic stability of whole-plant soybean silage (WPSS). Additionally, it was evaluated nutrients intake and digestibility of sheep fed increasing levels of WPSS. Thirty experimental silos were randomly allocated to one of the following treatments: 1) CON: control, WPSS without additives; 2) LPPA: WPSS with Lactobacillus plantarum and Pediococcus acidilactici; and 3) CHI: chitosan, WPSS with 5 g/kg of chitosan. Ten male sheep were used to evaluate increasing dietary levels of WPSS: 0, 200, 400, 600, and 800 g/kg of diet dry matter (DM). Additives increased silage lactic acid bacteria and decreased the count of mold and yeast, gas, and total losses. Silages treated with additives had lower pH, NH3-N, and ethanol concentrations and higher lactic and propionic acids relative to CON. LPPA-treated silos showed higher organic matter and non-fiber carbohydrates content than CHI-ones. Additives increased the aerobic stability of WPSS. The addition of WPSS in sheep diets linearly increased nutrients intake and digestibility. Chitosan and LPPA improve WPSS fermentation, aerobic stability, and nutritional value. The WPSS in substitution to Cynodon hay increases sheep feed intake and nutrients digestibility.
Relationship between location of epileptic focus and occurrence during sleep versus wakefulness
Authors: Narang Pooja , Garg Divyani , Shukla Garima , Singh Mamta Bhushan , Srivastava Achal , Gupta Anupama , Suri Ashish , Garg Ajay , Bal CS. , Vibha Deepti , Pandit Awadh Kishor , Prasad Kameshwar
Published: February 2022

Objective. Different sleep stages exert differential effects on interictal discharges, neural synchrony and seizure threshold. We sought to assess the relationship between localization of the epileptogenic focus and seizure distribution in sleep versus wakefulness among patients with refractory epilepsy.

Methods. We conducted a retrospective chart review‐based study. Video‐electroencephalography of patients with refractory epilepsy, planned for resective surgery, were reviewed for seizure localisation and occurrence relative to stage of sleep/wakefulness. Demographic/clinical data, including details of surgery, were also recorded. Bivariate analysis was conducted using the chi‐square test for proportions and unpaired t‐test/ANOVA to compare the means within groups.

Results. We enrolled 175 patients (107 males) with a mean age of 26.1 ± 9.8 years (range: 4‐53 years). We analysed 1,282 seizures, of which 916 (71.5%) were temporal, 95 (7.4%) frontal, 144 (11.2 %) central/ parietal and 19 (1.5%) arose from the occipital lobe. Temporal lobe onset seizures were more frequent during wakefulness (77.7%) compared to extra‐temporal localization (65%) (p<0.0001). Amongst temporal lobe onset seizures, those during wakefulness arose more frequently from the lateral temporal (88.6%) compared to the mesial temporal lobe (75.5%) (p=0.0003). A higher proportion of seizures evolved into secondary generalisation during sleep (23.5%) versus 8.7% during wakefulness (p<0.0001).

Significance. Our study demonstrates that lobar location of epileptogenic foci is associated with a predilection of seizures to occur, as well as secondarily generalise, during sleep/wakefulness. Seizures with lateral temporal lobe as well as extratemporal lobe onset were more likely to occur during wakefulness. Overall, sleep related seizures were more likely to be of extratemporal lobe onset, though.
De novo status epilepticus possibly related to battery depletion of anterior thalamic brain stimulator
Authors: Miron Gadi , Strauss Ido , Fahoum Firas
Published: February 2022

Anterior thalamic deep brain stimulation is an effective therapeutic option for patients with drug‐refractory focal epilepsy who are poor surgical candidates. Although the precise mechanism of action of thalamic neurostimulation is unknown, studies demonstrating increased efficacy over time have raised the possibility that therapeutic benefits are mediated by stimulation‐related long‐term neuroplastic changes. Adverse effects related to hardware malfunction have been previously described, and most commonly include local infection, sensory disturbances, and migration of leads. However, the withdrawal effect of sudden deep brain stimulation malfunction on seizure control is unclear. We present the case of a 21‐year‐old patient with intractable focal epilepsy who developed status epilepticus concurrently with unexpected deep brain stimulator battery failure, 21 months post implantation. This case demonstrates an unfamiliar possible adverse effect of anterior thalamic stimulation withdrawal and emphasizes the importance of stimulator hardware assessment in patients presenting with seizure worsening.
Determinants of postictal agitation and recovery after tonic‐clonic seizures in generalized and focal epilepsy∗
Authors: Dabir Aman , Zahoor Salman , Abou‐Khalil Bassel W.
Published: February 2022

Objective. The postictal state after bilateral tonic‐clonic seizures is often prolonged and can have significant impact on a patient's quality of life. Considerable variability exists in the magnitude of postictal agitation and in the speed of recovery, the determinants of which are not well understood. We studied postictal behavior after tonic‐clonic seizures in various epilepsy localizations, focusing on postictal agitation and time to responsiveness.

Methods. We retrospectively identified 15 adult patients each with idiopathic generalized, left temporal lobe, right temporal lobe and frontal lobe epilepsy. Localization in focal epilepsy was validated by good outcome after resective surgery at one‐year of follow‐up. The first tonic‐clonic seizure with reliable video and EEG for each patient was analyzed by two reviewers, one of whom was blinded to clinical data. Clinical, ictal and postictal variables were collected for each patient and analyzed. Postictal agitation was classified as mild and marked.

Results. We reviewed 60 tonic‐clonic seizures, 15 in each of four patient groups. Postictal agitation was observed in 14 patients (23.3%; marked in one and mild in 13). Postictal agitation was most common in patients with left temporal (seven patients) and least common in idiopathic generalized epilepsy (one patient) groups (p=0.035). Based on subgroup analysis (n=28), time to responsiveness was 6.6 minutes for frontal, 7.2 minutes for generalized, 10 minutes for right temporal and 15.7 minutes for the left temporal groups (p<0.05 for frontal vs. left temporal, generalized vs. left temporal). Time to responsiveness was longer in patients with agitation than without (13.9 minutes vs. 7.7 minutes; p=0.048). Patient ictal and postictal characteristics demonstrated no relationship to agitation or latency to postictal recovery.

Significance. To mitigate harm, patients must be monitored carefully after tonic‐clonic seizures, especially patients with left temporal lobe epilepsy. Studies evaluating medical and behavioral interventions to promote postictal recovery are needed.
Video game‐induced reflex seizures via a smartphone
Authors: Riva Antonella , Rebessi Erika , Parente Eliana , Viri Maurizio , Striano Pasquale , Romeo Antonino
Published: February 2022

Reflex seizures are consistently evoked by a specific afferent stimulus or by patient activity. Patients experiencing reflex seizures when playing a game on a mobile phone are rarely reported. We describe a boy with reflex seizures after prolonged exposure to the game, Cut the rope, on his mobile phone. The video‐EEG documented electroclinical events characterized by distal myoclonic jerks of the upper limbs, in combination with irregular, diffuse spike‐and‐wave and polyspike‐and‐wave discharges on EEG, followed by a tonic‐clonic seizure. Playing video games on mobile phones may potentially induce reflex seizures, similar to other commonly used platforms such as docking stations connected to video screens.
Let's all repeat – palilalia may be epileptic!
Authors: Nascimento Fábio A. , Gavvala Jay R.
Published: February 2022

Content available: Video
Evaluación del comportamiento biomecánico de dos diseños protésicos implantosoportados
Authors: Latorre Federico
Published: February 2022

RESUMEN: planteamiento del problema: existen alternativas de rehabilitación fijas como removibles, sin embargo, hay pocos estudios disponibles que analizan el comportamiento biomecánico de estas prótesis con un control de las variables biológicas como tipo de hueso, ubicación y tipo de implantes. El objetivo de este estudio fue analizar el comportamiento biomecánico de dos diseños de prótesis mandibulares soportadas en cuatro implantes y las zonas biológicas adyacentes.  Materiales y métodos: se realizó la modelación de dos diseños protésicos mandibulares sobre 4 implantes Zimmer TSV (Zimmer Biomet) en un hueso con características D2 (Misch) asumiendo un porcentaje de oseointegración del 75%. El primer diseño fue una sobredentadura (OD) con una barra interna de refuerzo en CrCo, retenida con ajustes Locator (Zest Anchors), el segundo diseño fue una prótesis híbrida (HP) metal-acrílica en la que en lugar de utilizar la barra CAD/CAM ferulizando los implantes, se  diseñó una barra interna de refuerzo en CrCo, la carga aplicada en cada modelo fue de 400N distribuidos en toda la prótesis.  Resultados: los esfuerzos se concentraron principalmente en la porción crestal del hueso periimplantar en ambos diseños, los esfuerzos en la porción trabecular fueron mínimos, en el hueso periimplantar el mayor esfuerzo se presentó en OD 20,643 MPa, en el diseño HP 11,823 MPa, los esfuerzos en los implantes fueron mayores en HP 67.8 MPa que en OD 52,613 y en la prótesis  el mayor esfuerzo se presentó en HP, 56,046 MPa comparado con 41,518 MPa en OD. conclusiones: el funcionamiento de los diseños no es igual y transmiten esfuerzos diferentes, pero ninguno de los dos comprometio las estructuras biológicas ni protésicas analizadas.
[RETRACTED] Gro X Male Enhancement :Shocking Price for Sale & Real Customer Complaints v1
Authors: not provided groxenhancement
Published: February 2022

[RETRACTED]

People suffering from low sex drive take male enhancement pills to enhance their sexual desire. However, most of these pills do not act on the root cause of low libido. Therefore, one requires taking the pills on a daily basis leading to addiction.
INOVASI PRODUK KUE TRADISIONAL ALI AGREM MENGGUNAKAN BAHAN DASAR TEPUNG UBI UNGU
Authors: Dwi Septiani Adhita , Sudono Agus , H.Rumayar Christian
Published: February 2022

Penelitian ini bertujuan untuk mengetahui konsentrasi tepung ubi ungu yang terbaik dalam pembuatan Kue Tradisional Ali Agrem, sehingga produk inovasi kue Ali Agrem Tepung Ubi Ungu dapat disukai panelis dan dapat diterima konsumen. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian deskriptif eksperimental. Dengan mengambil populasi yaitu 15 orang panelis pencicip perorangan untuk menilai konsentrat produk terbaik dari tiga sampel di Hotel Grand Pasundan Convention Hotel, penjual kue Ali Agrem, toko SoekarnoHatta, mahasiswa/i pastry. Disebarkan kepada 50 orang konsumen untuk mengetahui daya terima konsumen. Metode pengumpulan data dilakukan dengan membagikan kuisioner kepada panelis dan konsumen. Metode analisis data yang digunakan yaitu uji hedonik Analisis Varian (ANAVA), Least Significant Difference dan pengolahan data dengan bantuan Microsoft Excel 2010. Dari hasil penelitian yang diperoleh, Kue Ali Agrem Tepung Ubi Ungu yang mempunyai konsentrasi terbaik yaitu kue Ali Agrem yang memiliki perbandingan 1:1,5 (100 gram tepung beras dan 150 gram tepung ubi ungu).
PENGARUH KUALITAS PRODUK DAN KUALITAS PELAYANAN TERHADAP KEPUASAN KONSUMEN DI SUSHI DEN BANDUNG
Authors: Anggraeni Devi , Sudono Agus , Turgarini Dewi
Published: February 2022

Customer satisfaction is the most important thing in the catering business. Customer satisfaction affect the profit earned by entrepreneur food. Things that can affect customer satisfaction among them is the quality of product and quality of services provided by the food producers.One way to determine customer satisfaction is to compare the expectation and the reality perceived by the customer.Research method used in this research is descriptive verification method. The number of samples in this research were 100 consumers, data collection is done by spreading the questionnaire and documentary study. Model analysis of the data used is multiple linear regression using SPSS 22 for windows. The results showed that the Product Quality and Service Quality has significant impact on customer satisfaction. Results of calculations using multiple linear regression analysis obtain the equation Y=3,291+0,059X₁+0,152X₂ it means an increase by 1 unit Product Quality, the Consumer Satisfaction Sushi Den Bandung will increase by 0.059 and any increase Quality of Service by 1 unit, the Consumer Satisfaction Sushi Den Bandung will also rise by 0.152. Food producers should further improve the quality of product quality and service quality by determining and implementing the Standard Operational Procedure properly in order to provide a positive impact for food company.
PELESTARIAN MAKANAN TRADISIONAL KEJOS SEBAGAI SUMBER KARBOHIDRAT DI DESA TARIKOLOT KECAMATAN JATINUNGGAL KABUPATEN SUMEDANG PROVINSI JAWA BARAT
Authors: Rahmalianti Risa , Nur Alia Mirna , Riyadi Dony
Published: February 2022

This research is focused on discuss about traditional food which is based on cassava, it is called kejos and it is rarely found in Tarikolot subdistrict Jatinunggal district Sumedang Province Jawa Barat now. This traditional food have a good taste and has a property glut Such as rice. Kejos which is based on cassava has a good potensial, because it can grow in every weather and every year. And it is also can be found everywhere.There is a lot of nutritions in cassava such as carbohydrate. The level ofcarbohydrate in cassava if we compared with rice is the third. First is rice and thesecond is corn. This traditional food is also has a story to citizen in Tarikolot thattime. It will be disappointed if this traditional food disappear.Therefore, the writer make some innovation to make this traditional foodbecome popular.
The Influence of Flavor on The Purchase Decision Of Bakpia Mutiara Jogja
Authors: Pratama Galuh
Published: February 2022

The purpose of this study is to determine the influence of flavor on the purchasing decision of Bakpia Mutiara Jogja. This study uses a quantitative approach. The population of this research are consumers who have bought bakpia at Bakpia Mutiara Jogja store. The sampling technique uses purposive sampling. The sample in this study are 100 consumers who have bought bakpia more than once in Bakpia Mutiara Jogja store. This research using simple regression analysis method. The results shows that flavor have a positive and significant influence on the purchasing decision of Bakpia Mutiara Jogja (sig = 0,000 0.05 and regression coefficient = 0.432).
Preservation of Dodol Moyog as a Gastronomic Tourist Attraction in Cirebon Regency
Authors: Darwis Riadi , Nur Baity Mutiara Rizky
Published: February 2022

Dodol moyog, a snack that has a unique name, is a traditional food originating from Cirebon Regency which is currently very rare to find, even many local people do not know the dodol moyog snack itself. This study aims to determine the gastronomic concept of dodol moyog including history, philosophy, tradition, social, and to analyze the method of cooking the traditional Cirebon regency snack, the equipment used and the manufacturing standards, and efforts to preserve dodol moyog. The research method used is a qualitative method, while the data collection technique is done by interviewing, observing, studying literature and studying documentation. The result of this research is that no one knows for sure how the history of dodol moyog is called dodol moyog because in the process of making it in “oyog-oyog” or stirred. The ingredients used to make dodol moyog are tapioca flour, brown sugar, salt and water. While the ingredients for making “mata ula” are coconut milk and sugar. Support from various parties is needed in the development of the dodol moyog business so that it can attract tourists to make dodol moyog a gastronomic tourism destination in Cirebon Regency.