bluuebunny/crossref_metadata_2025 huggingface dataset:
Biochemical Markers in Nodular Goiter in Children Indications, methods and outcome of the Surgical Treatment
Authors: Varcus Flore , Ciobanu Gabriela Delia , Grigorovici Alexandru , Hinganu Marius Valeriu , Hinganu Delia , Leustean Letitia
Published: January 2020

Nodular goiter is a rare condition in children and adolescents and compared with adults, thyroid nodules are more frequent malignant in pediatric population. We have investigated the prevalence of thyroid carcinoma among the thyroid disorder emphasizing on the surgical treatment in term of indication, methods and complications. Retrospective study of 35 children and adolescents with nodular goiter. Demographic data, thyroid ultrasonographic features, fine needle biopsy aspiration, hormonal profile, surgical treatment procedure as well as histological aspects were recorded. Study included 26 (74%) girls and 9 (26%) boys with a mean age of 11.66 years. Fine needle aspiration biopsy was performed in 10 cases due to the TIRADS score � 4 with Bethesda II in 3 cases, Bethesda III in 4 cases and Bethesda V in 3 cases. The surgical treatment was performed in 16 (45.7%) cases due to fine needle aspiration biopsy results or due to the relapse after medical treatment. Lobectomy was performed in 7 (43.7%) cases while total thyroidectomy was the final option for the rest of 9 (56.3%) patients. As a result of pathological examination in 8 cases the thyroid carcinoma has been found. The rest of 8 patients presented benign thyroid findings (follicular adenoma, toxic adenoma and Graves� disease with follicular adenoma). The prevalence of thyroid carcinoma among the pediatric population with thyroid nodules was 22.8% most affected being the female gender.
Time Trends: A Ten Years Comparison (2005/2006-2015/2016) of Alcohol Misuse During First Year in Medical School
Authors: Horhat Razvan Mihai , Bagiu Radu-Vasile , Vlaicu Brigitha , Hutanu Delia , Horhat Delia-Ioana , Nica Luminita , Iacob Daniela , Arghirescu Smaranda , Bagiu Iulia-Cristina
Published: January 2020

The purpose of the present study was to explore time-trends (2005/2006-2015/2016) of alcohol misuse in first year medical students and types of alcohol preferred by young adults in the same medical school. The study compared two cross-sectional cohorts of medical students (2005/2006: 365 females and 249 males; 2005/2016: 336 females and 123 males) from Timisoara, Romania, using the same questionnaire in both investigations. The analysis was conducted measuring gender and cohort effect on frequency of alcohol use patterns during the last month and the type of alcohol used preferred. Girls have increased with a small effect size both the number of days consuming at least one portion of alcohol and the number of days with binge drinking between evaluations, reducing the gap between boys and girls, seen in 2005/2006 evaluation. In multivariate models, though beer consumption has decreased (OR=0.6) between evaluations, wine (OR=3.6) and spirits (OR=1.6) consumption has increased. Beer and spirits are the type of alcohol used by young people for binge drinking. Interventions to reduce misuse of alcohol in general population or specific to university students need to be carefully tailored to the shifting patterns of alcohol consumption, which are gender specific.
First Line Therapy in Multiple Myeloma: VAD vs Bortezomib -Dexamethasone
Authors: Borsi Ema-Cristina , Bucur Adina , Oncu Cristina Potre , Oncu Ovidiu Potre , Cerbu Bianca , Costachescu Dan , Ionita Ioana , Luca Constantin Tudor , Ionita Hortensia
Published: January 2020

Multiple myeloma (MM) is typically sensitive to a range of cytotoxic agents, both as initial therapy and as relapsed disease treatment. Unfortunately, the responses are transient, and MM is not considered curable with the current approaches. This paper aims to assess the response to first line treatment of patients included in the study and their correlation with the negative prognostic factors in multiple myeloma: age over 60 years, male gender, anemia, hypercalcemia, elevated levels of creatinine, Beta 2 microglobulin, hypoalbuminemia and Bence-Jones proteins type. The study was conducted on a group of 105 patients admitted to the Hematology Department of the Municipal Emergency Clinical Hospital of Timisoara from 01 January 2013 until 31 December 2017. Twenty-seven patients received VAD regimen, while 78 underwent Bortezomib + Dexamethasone regimen as fist line therapy. When analyzing anthropometrical data, different gender distribution in the two groups of patients is seen, while a higher percentage of patients over 60 years is observed in both groups, with 77.7% in the VAD group (21 out of 27 patients) and 56.4% in the group treated with Bortezomib + Dexamethasone (44 out of 78 patients). Only some of the factors analyzed in our study statistically significantly influenced the response to treatment and the duration of survival, i.e.: age over 60 years, hemoglobin [10g/dL, platelets under 150000/mm3, creatinine ]2mg/dL, serum calcium ]10mg / dL, increased C-reactive protein, low serum albumin levels, high levels of Beta 2 microglobulin, total serum protein, as well as presence of cells in the peripheral smear. Defining a panel of negative prognostic factors that influence the evolution and response to multiple myeloma treatment would allow for tailoring of personalized therapies for each patient.
Value of Autopsies in the Study of Diagnostic Errors in Respiratory Medicine
Authors: Turcu Diana Veronica , Turcanu Adina Magdalena , Grigorescu Cristina , Patrascu Alexandru , Chiselita Irina , Mihaescu Traian
Published: January 2020

Diagnostic errors are real and are causing harm to patients on a global scale. However, the methods for measuring diagnostic errors are underdeveloped. One very important tool in this regard is the use of autopsies, in order to point out the cases where the actual affliction was missed and to quantify the incidence of such mistakes. We have carried out a study to compare the clinical diagnostic with the post mortem autopsy report in 119 patients who have died at the Pulmonology Hospital in Iasi, Romania, between January 2nd 2016 and January 2nd 2017. The purpose of this research is to determine the incidence of diagnostic errors and to identify the most missed or overlooked respiratory diseases.
The Role of Antithrombin III in the Pathogenesis of the Thrombotic Status in Type 2 Diabetes Mellitus
Authors: Bararu-Bojan Iris , Vladeanu (Apavaloaie) Maria Cristina , Bojan Andrei , Sirbu Paul-Dan , Ciocoiu Manuela , Badulescu Oana
Published: January 2020

Diabetes mellitus is one of the costliest chronic pathology worldwide with a continuous rising incidence. Diabetes mellitus is linked to frequent cardiovascular events. It is associated with vascular events, especially when the glycated hemoglobin has elevated values. Diabetic patients seem to develop abnormalities of the haemostatic process, such as alterations of the thrombocytic function, modifications of the coagulation and of the fibrinolysis that lead to a thrombophillic status. The acquired thrombophilia present in diabetic patients may be due to the non-enzymatic glycosilation of clotting inhibitors such as antithrombine. Antithrombin III has both an anticoagulant and an antiinflammatory effect. The anticoagulant effect appears after acting upon endothelial heparan sulfate or on the molecule of heparine, thus leading to an inhibition of thrombin. A decrease in antithrombin III levels may lead to a diminished neutralisation of thrombin and a lower activity of proteins C and S, thus inducing procoagulant consequences and increasing the susceptibility for thrombotic events. Our research tried to establish whether the levels of antithrombin III in type 2 diabetic patiens are modified, thus creating a predisposition for thrombotic events. Therefore we conducted an observational study on a sample composed of 60 patients having a diagnostic of type 2 diabetes associated with coronary artery disease, controlled with diet or with oral antidiabetics and we evaluated the levels of antithrombin III in function of the metabolic, inflammatory and coronarographic parameters. Our research showed that even though all patients were characterized by the diabetic dyslipidemia, there was no statistic relationship between antithrombin III and the lipidic fractions. As a result we cannot say that the adverse cardiac events seen in type 2 diabetic patients are influenced by the levels of antithrombin III, as a marker of an increased clotting activity.
The Contribution of Stress Level in Modifying the Cardiometabolic Risk in a Population Cohort from North-East Romania
Authors: Lunguleac Tiberiu , Azoicai Doina , Manole Alina , Patrascu Alexandru , Moscalu Mihaela
Published: January 2020

The cardiometabolic risk is used to assess the probability of developing a cardiovascular disease in association with diabetes. The research of stress factor represents a breakthrough in assessing this risk. The study aim was to evaluate the importance of cardiometabolic risk measurement instruments in the context of psycho-behavioral factors expressed by individual stress level. The cross-sectional study consisted of applying a PSL assessment questionnaire to a group of 254 individuals. Quantification of the PSL was achieved by a previously validated standardized questionnaire (PSS Scale). The research involved completing the questionnaire and corroborating clinical and paraclinical data (LDL-cholesterol, glycemia, glycosylatedhemoglobin - HbA1c). Data were analyzed using the SPSS V.21 software (IBM). The calculation of global cardiovascular risk score (SCORE) highlighted that 75% of cases presented a risk for a cardiovascular event over the next 10 years of lower than 3 (30%). Fasting glycemia values showed significant differences compared to glycosylated hemoglobin values (tvalue= 8.68, p[[0.01, 95% CI). It is noted the absence of significant differences between the calculated mean value and the normal LDL maximum threshold (tvalue = 0.96, p = 0.336). Mean values of females perceived stress score (MPSS/female = 20.9 � 6.43SD) are significantly higher (F = 30.7, p [0.05, 95% CI) versus males (MPSS/male = 16.5 � 5.92SD), but there is no correlation between patient�s age and perceived stress score (r = 0.028, p = 0.651, 95% CI). Correlation of socio-economic factors with PSL reveals that low educational level (r = -0.203, p = 0.001) and low income (r = -0.204, p = 0.001) significantly increase the PSL. The results indicate that there is no correlation between perceived stress score and cardiovascular risk score (r = -0.0936, p = 0.137, 95% CI). Aspects revealed by study results highlight the need for monitoring stress factor in actions of clinical management in patients at high cardiometabolic risk.
Clinical Impact of Association Between Diabets and Lung Cancer
Authors: Mazilu Laura , Stanculeanu Dana Lucia , Gheorghe Andreea Daniela , Suceveanu Adrian Paul , Parepa Irinel Raluca , Stoian Anca Pantea , Suceveanu Andra-Iulia
Published: January 2020

The main objective of this analysis is to evaluate the impact of lung cancer and diabetes association on cancer treatment and outcome of lung cancer patients. Lung cancer, as well as diabetes mellitus, are two diseases with very high prevalence. Lung cancer, despite the improvement in diagnosis and therapeutic methods, is still the 1st cause of cancer-related deaths. The influence of diabetes on cancer patients survival is well established among patients with hepatic, pancreatic or breast cancer. Diabetes implication on lung cancer outcome is not well known. Several studies reported a negative impact, whereas other studies reported a better prognosis for these patients. Our study took place in the Oncology Department of the Clinical Emergency Hospital of Constanta, Romania. 80 patients with diagnosis of non-small cell lung cancer were elected to participate in this study; 29 patients had also diabetes. Selected patients were divided in 2 groups, one group of lung cancer and diabetes, and one group without diabetes. Features of the patients among both groups were analyzed. Our study showed that preexisting diabetes is an unfavorable factor, and has influence on lung cancer prognosis, treatment adhesion and quality of life. To amend the outcome of patients with lung cancer, a better evaluation of patients� co-morbidities, including diabetes mellitus, is required.
Corneal Crosslinking in Progressive Keratoconus: Comparison of Dextran-Based and Hydroxypropyl Methylcellulose-Based Riboflavin Solutions Differences in demarcation line depth and 1 yaear outcomes
Authors: Burcel Miruna Gabriela , Corbu Catalina , Coviltir Valeria , Potop Vasile , Constantin Mihaela , Dascalescu Dana , Ionescu Catalina , Ciuluvica Radu , Voinea Liliana Mary
Published: January 2020

Keratoconus is a progressive ectatic disorder characterised by irregular myopic astigmatism and loss of visual acuity due to corneal thinning. Corneal collagen crosslinking is the treatment recognised to stop the progression of keratoconus. Our study evaluates and compares visibility and depth of the stromal demarcation line after corneal collagen crosslinking using anterior segment optical coherence tomography between two groups:crosslinking with dextran-based and hydroxypropyl methylcellulose-based riboflavin solutions. Our work proved a better visibility and a deeper demarcation line when we used HPMC-based riboflavin. Also the study revealed that HPMC-based riboflavin is associated with better biomechanical outcomes than dextran-based riboflavin.
Phenolic and Mineral Composition of Wild Chicory Grown in Romania
Authors: Stanciu Gabriela , Rotariu Ramona , Popescu Antoanela , Tomescu Aneta
Published: January 2020

The paper presents original results concerning phenolic and mineral composition of different parts of wild chicory grown in Romania (flowers, leaves, stems and roots). Total and some individual phenols concentrations were determined using molecular absorption spectrometry (modified Folin Ciocalteu method) and HPLC-DAD. Metals concentrations were measured by FAAS. The highest total phenolic compounds concentration was founded in flowers (1531.2 mg GAE/100g d.w.), followed by leaves (1180.3 mg GAE/100g d.w.), roots (167.86 mg GAE/100g d.w.) and stems (142.36 mg GAE/100g d.w.). HPLC-DAD analysis revealed the presence of seven phenolic acids in the range of 30-50% from total phenols concentration. The main determined phenolic compounds are: in flowers methyl gallic acid (301.55 mg/100g d.w.) in leaves, roots and stems ellagic acid (389.68 mg/100g d.w., 67.93 mg/100g d.w. respectively 22.97 mg/100g d.w.). Metals analyses by FAAS indicate that Cd, Cr, K, Ni and Pb are in concentrations under the detection limits. Except iron and sodium, all others metals are in higher concentration in leaves. Rank for the metal concentration from chicory was Ca]Mg]Zn]Na]Cu]Fe]Mn.
Influence of Thermal Comfort on Health
Authors: Rusanescu Carmen Otilia , Rusanescu Marin , Jinescu Cosmin , Paraschi Gigel
Published: January 2020

The purpose of this paper is to estimate the conditions of human comfort in Bucharest. To describe the influence of the climate on human health, several indices have been developed describing the degree of physiological comfort offered by the meteorological conditions, taking into account meteorological parameters registered daily by the weather station at the Polytechnic University of Bucharest, Faculty of Biotechnical Systems Engineering: temperature and relative air humidity, wind speed. The following indices were analyzed: summer SCHARLAU index (ISE), winter SCHARLAU index (ISH), thermohigrometric index (THI), wind cooling power (skin stress index) (P), temperature equivalent to cooling wind power Tpr, to determine the influence of thermal comfort on health.
Densities, Viscosities and Refractive Indices of Ternary System Cyclohexane + Cyclohexanol + Cyclohexanone at 293.15, 298.15 and 303.15 K
Authors: Budeanu Maria Magdalena , Dumitrescu Vasile
Published: January 2020

Densities (r), viscosities (h) and refractive indices (nD) of the ternary system cyclohexane + cyclohexanol + cyclohexanone were measured at 293.15, 298.15 and 298.15 K and atmospheric pressure, over the whole composition range. The experimental values of densities and viscosities were correlated with temperature using a linear equation and Guzman equation respectively. Viscosity results were fitted with Grunberg-Nissan equation and Heric-Brewer equation. Different refractive index mixing rules (Arago-Biot, Dale-Glastone, Newton and Lorentz-Lorenz) were studied for this ternary system. The functions of activation of viscous flow were also calculated and their variations with compositions have been discussed.
Study on Reconstruction Techniques of the Nipple-Areola Complex
Authors: Marinescu Silviu Adrian , Bejinariu Catalin Gheorghe , Badeana Andreea , Tanasescu-Ciuvica Sabina , Enescu Dan Mircea
Published: January 2020

Increasing the incidence of breast cancer worldwide is an alarming factor for the medical community and also an additional reason for accountability. Oncological treatment, followed by subsequent reconstructive stages, are traumatic events that without a doubt exert their adverse effects on the quality of life of these patients. The reconstruction of the nipple-areola complex represents the final element in the treatment of patients who have suffered from cancer breast and must follow basic principles such as: reproducibility, efficacy, short duration of treatment and low rate of complications. The present material presents the various surgical techniques dedicated to the reconstruction of the nipple-areola complex, presenting their advantages and disadvantages based on a 5-year study. The use of single-stage techniques associated with medical tattooing were the main factor in increasing the satisfaction of the patients included in the research.
Iodoform (triiodomethane)- An Old, but Still Extremely Efficient Antiseptic
Authors: Dimitriu Mihai , Socea Bogdan , Ionescu Cringu Antoniu , Ples Liana , Gheorghiu Diana-Claudia , Constantin Vlad Denis , Cirstoveanu Catalin-Gabriel , Bacalbasa Nicolae , Furau Cristian George , Davitoiu Dragos Virgil , Gheorghiu Nicolae
Published: January 2020

Iodoform (triiodomethane), a yellow crystalline solid, belonging to the family of organic halogen compounds, is used as an antiseptic. Its antiseptic action is due to the slow release of iodine under the action of catalase from wounds. Currently, it is widely used only in dentistry and in veterinary medicine. We have extended, with good results, the use of iodoform as an antiseptic for other types of surgical or traumatic wounds that have been infected with piogens. Between 2009 and 2018, on 242 cases of different wounds, we obtained good results, with no severe adverse effects.
Effects of Thermal and Ultrasound Treatments on L Ascorbic Acid of Grapes Juice
Authors: Lupu Mirabela Ioana , Badarau Carmen Liliana , Padureanu Vasile , Canja Cristina Maria
Published: January 2020

Improving the nutritional quality for non-alcoholic beverages (especially the content of valuable natural antioxidants) by using modern ultrasound treatments represent a challenge for more and more food scientists. The objective of this research work was to estimate the effect of some ultrasound treatments on the total L ascorbic acid content and on several physicochemical characteristics of grape juice stored for different time periods. In order to determine this influence, the sonication parameters chosen were the amplitude (60%, 80%) and the treatment times (18, 36 min.). The samples treated by direct sonication (amplitude 80%, 36 min.) and stored 17 days had higher values of total L ascorbic acid content.
Synthesis and Characteristics of Local Fly Ash Based Geopolymers Mixed with Natural Aggregates
Authors: Burduhos Nergis Dumitru Doru , Vizureanu Petrica , Corbu Ofelia
Published: January 2020

Global industrialization generates large amount of waste which strongly affects the depositing areas and the living creatures from the surroundings. In the same time, the construction sector meets an exponential development process, resulting in materials and construction areas increase. Therefore, the need of new materials was felt worldwide. One solution that knew a rapid development, especially in this sector, was to obtain new eco-friendly materials through a mechanism called geopolymerization. True this powerful chemical reaction between a waste, rich in aluminum and silicon, and a strong alkaline solution, a tetragonal structure of Al-O-Si is obtained that possess properties comparable to those of Portland cement-based concrete. In the present paper the effect of aggregates on local fly ash based geopolymers is analyzed from the structure and mechanical properties point of view. According to this study, the aggregates strongly influence the density, compression strength and flexural strength at any age of samples.
Antithrombotic Therapy in Patients with Stroke An observational study
Authors: Cuciureanu Dan Iulian , Constantinescu Victor Alexandru , Statescu Cristian , Sascau Radu Andy , Hodorog Diana Nicoleta , Preda Cristina , Hinganu Delia , Hinganu Marius Valeriu , Cuciureanu Tudor
Published: January 2020

Cerebrovascular disease is the second leading cause of death in developed countries after cardiovascular disease, with a prevalence of 794 percent of hundred thousand of people. Ischemic stroke (IS) remains an important public health issue of great importance in terms of its reality and the morbidity it implies, although the tendency is to reduce epidemiological indicators. In this paper we have updated informations on etiopathogenesis, epidemiology, pathological anatomy, clinical, laboratory and imaging investigations, differential diagnosis, evolution, complications, prophylaxis with antiplatelet treatment of patients with IS. IS remains an important public health issue of great importance in terms of its reality and the morbidity it implies, although the tendency is to reduce epidemiological indicators. Platelet function testing may potentially be useful in monitoring the biological effect of platelet antiaggregant medication. Aggregometry could provide personalized prognostic information and may thus become a useful tool in designing strategies for prevention and management of ischemic stroke.
The Effect of Some Amphiphilic Porphyrins on the Transmembrane Potential of Cultured L929 Cells
Authors: Radulea Natalia , Boscencu Rica , Socoteanu Radu , Manda Gina , Neagoe Ionela Victoria
Published: January 2020

This study include in the same frame promising structures tailored as photoactive agents for photodynamic therapy of cancer versus one of the most versatile cell lines from experimental point of view, fibroblasts type, subcutaneous connective tissues- L929. Transmembrane potential was studied establishing important features in the behavior of chemical vectors against cultured cells via membranar media. Two amphiphilic porphyrins, 5,15-bis-(4-hydroxy-3-methoxyphenyl)-10,20-bis-(4-carboxymethylphenyl)porphyrin and Zn(II)-5,15-bis-(4-hydroxy-3-methoxyphenyl)-10,20-bis-(4-carboxymethylphenyl)porphyrin were assessed in terms of the effect on membrane potential. The comparative effect of free base porphyrin and metalloporphyrin with amphiphilic structure, reveal hyperpolarization phenomena and bring informations about consequences of active compound concentration against cell membrane.
Biocompatible Titanium Alloys used in Medical Applications
Authors: Baltatu Madalina Simona , Tugui Catalin Andrei , Perju Manuela Cristina , Benchea Marcelin , Spataru Mihaela Claudia , Sandu Andrei Victor , Vizureanu Petrica
Published: January 2020

At global level, there is a continuing concern for the research and development of alloys for medical and biomedical applications. Metallic biomaterials are used in various applications of the most important medical fields like orthopedic, dental and cardiovascular. The main metallic biomaterials used in human body are stainless steels, Co-based alloys and Ti-based alloys. Titanium and its alloys are of greater interest in medical applications because they exhibit characteristics required for implant materials, namely, good mechanical properties (less elasticity modulus than stainless steel or CoCr alloys, fatigue strength, high corrosion resistance), high biocompatibility. The aim of this review is to describe and compare the main characteristics (mechanical properties, corrosion resistance and biocompatibility) for latest research of nontoxic Ti alloys biomaterials used for medical field.
Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles
Authors: Balaban Mihaela , Virgolici Bogdana , Dinu Adriana , Totan Alexandra , Miricescu Daniela , Stefan Daciana , Greabu Maria , Mohora Maria
Published: January 2020

Glucocorticosteroids are the mainstay of treatment in many inflammatory and autoimmune disorders. Their administration can be associated with various side effects, similar to those within the metabolic syndrome. The beneficial effects of vitamin E in metabolic syndrome were demonstrated by many studies. Nowadays, vitamin E can be administrated through a new and innovative system delivery, such as polylactic-co-glycolic acid nanoparticles (PLGA-NPs). The aim of this experimental study was to compare the metabolic and haematological parameters after Prednisone administration as a single drug or in combination with vitamin E delivered by PLGA-NPs. Wistar male rats (n=15, age 10-12 months), on standard diet were randomised in three groups, for 6 weeks as: group SC served as a control, group SP was treated with Prednisone (1 mg/kg/day) by oral gavage and group SN received Prednisone (1 mg/kg/day) and vitamin E-charged PLGA nanoparticles (1 mg/kg/day) by oral gavage. In the Prednison treated group versus control, higher levels (p[0.05) were demonstrated for visceral fat weight, glycosylated hemoglobin (HbA1c), cholesterolemia and triglyceridemia. The association of PLGA-NPs charged with vitamin E to Prednisone prevented (p[0.05) hypercholesterolemia and visceral fat development induced by the cortisol intake. In conclusion, polylactic-co-glycolic acid nanoparticles (PLGA-NPs) charged with Vitamin E may demonstrate promising results in decreasing side effects induced by glucocorticosteroids, by reducing the amount of visceral fat and cholesterolemia.
The Predictability of Difficultness of Lower Third Molar Odontectomy
Authors: Roi Ciprian Ioan , Ianes Emilia , Gaje Pusa Nela , Nica Diana Florina , Roi Andrei , Roi Alexandra
Published: January 2020

The aim of this study was to establish an accurate algorithm for third molar odontectomy in order to help the surgeon to predict the duration and the difficultness of this surgical procedure. As material and methods, we used an algorithm that contains medical and radiographic data regarding lower wisdom tooth which was systematized in a preoperative questionnaire. In this study were included 27 patients with asymptomatic lower third molars during the period of 2015-2017. The prediction of the questionnaire was correlated with the difficulty and duration of the odontectomy. Results of our study showed that this algorithm can successfully predict the degree of difficulty of the lower wisdom tooth odontectomy and can guide the surgeon in the therapeutic decision. Moreover, this method is simple, easy and fast.
The Treatment of a Dental Morphological Anomaly Type Dens in Dente A challenge
Authors: Earar Kamel , Todor Liana , Porumb Anca
Published: January 2020

Dens in dente or the amelo-dentinal invagination is met rarely and involves, almost in exclusivity, the upper lateral incisisors, usually unilateral, being an invagination in glove finger of the enamel in dentine, on the level of a tooth often dismorphic. The radiologic aspect is of candle flame, occupying the central part of an upper lateral incisor.
Retrieving Broken Metallic Instruments from Root Canal by Using the Ultrasound System and Endodontic Microscope
Authors: Moraru Iren , Gheorghe Anca , Raca Ana Maria , Diaconu Cezar , Diaconu Oana , Gheorghita Lelia
Published: January 2020

During root canal instrumentation several accidents may occur, one of them being the separation of the instrument.The chemical structure of metallic boken instrumenthas an important role in the therapeutic approach. Due to metal fatigue, over instrumentation, incorrect speed, bad technique, and several other reasons, the endodontic instruments, manual or rotative, may break inside the root canal. The broken piece usually gets stuck inside the dentine walls. Several years ago, such accident was equal to the loss of the tooth, but nowadays, with the use of the endodontic microscope and ultrasonic tips, the teeth can be fully restored as the separated instrument can be removed safely.
The TAC and MDA Values in Patients with Chronic Suppurative Otitis Media
Authors: Serban Roxana , Badescu Codruta , Palade Dragos Octavian , Badescu Magda , Filip Catalina , Diaconu Iulia Elena , Mocrei Ariadna , Haba Danisia , Cobzeanu Mihail Dan
Published: January 2020

The oxidative stress is linked to many chronic diseases.The aim of the study was to assess the oxidative stress in chronic suppurative otitis media. The prospective study included a group of 60 patients with different forms of chronic suppurative otitis media (CSOM), cholesteatoma recidivism and a control group of 30 healthy people. The total antioxidant capacity (TAC) and malondialdehyde (MDA) concentrations were determined in serum of thepatients. We noticed a significant lower mean of TAC levels (p[ 0.001) in patients with chronic suppurative otitis media (CSOM) with and without cholesteatoma compared to the control group. The MDA had significantly higher mean values (p[ 0.001) compared to the healthy group.The imbalance of antioxidant systems to oxidizing molecules plays an important role in the pathogenesis of CSOM with and without cholesteatoma.
XOR - Possible Correlations with Oxidative Stress and Inflammation Markers in the Context of Diabetic Kidney Disease
Authors: Totan Alexandra , Balcangiu-Stroescu Andra-Elena , Melescanu Imre Marina , Miricescu Daniela , Balan Daniela , Stanescu Iulia-Ioana , Ionescu Dorin , Timofte Delia , Tanasescu Maria Daniela , Greabu Maria
Published: January 2020

Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species. The aim of our study was to investigate possible correlations of XOR serum levels with oxidative stress (total antioxidant capacity - TAC, anti-oxidative stress responsive 1 antibody - OXSR1) and inflammation markers (interleukin 6 - IL-6), in 20 hemodialysis diabetic patients. The present study included the hemodialysis diabetic patients group (10 males and 10 females) and the control group (20 healthy volunteers). For serum XOR (ng/mL), TAC (U/mL) and OXSR1 (ng/ml) measurements we have used the ELISA technique. Serum IL6 (pg/mL) was performed using an automatic immunoassay system (Immulite 1000, Siemens- Germany). Comparing the two groups, our results revealed significantly increased serum levels for XOR (6.2�1.5 / 3.9�1.1); OXSR1 (11.3�2.9 / 6.2�2.1) and IL6 (7.0�1.2 / 5.0�0.4). Patients� serum levels of TAC were significantly decreased compared with the control group values (25.2�3.9 / 33.5�2.8). It becomes more and more obvious that oxidative stress is an important element initiating diabetic microvascular complications, including diabetic kidney disease. Our results suggested that XOR should be regarded as an important target in the attempt to reduce oxidative stress in the context of diabetic kidney disease.
Clinical and Biochemical Changes Induced by Alcohol at the Patients with Mental Illness
Authors: Gheorman Victor , Dinescu Venera Cristina , Criciotoiu Oana , Stanca Diana , Calborean Veronica , Mita Adrian , Miscoci Alina , Davitoiu Dragos Virgil , Baleanu Vlad Dumitru , Nedelcuta Ramona-Mihaela , Dinescu Sorin Nicolae , Dijmarescu Anda Lorena , Voiculescu Daniel-Iulian , Udristoiu Ion
Published: January 2020

Alcoholism use disorders are very frequent present all over the world. The use of alcohol is responsable for many behavioral symptoms like impulsivity, violence, depressive mood and anxiety. The aim of our research was to find the clinical and the biochemical changes induced by alcohol at the patient with mental illness.
Thermography as Method of Paraclinic Diagnosis in Diabetic Polyneuropathy
Authors: Firescu Dorel , Sascau Radu Andy , Raftu Gheorghe , Statescu Cristian , Cuciureanu Tudor , Cuciureanu Dan Iulian
Published: January 2020

The concept of polyneuropathy comprises the etiological diversity of neurological syndromes characterized by the formation of bilateral and symmetrical lesions of limb peripheral nerves; symmetrical distal sensory-motor polyneuropathy is the most common form of diabetic neuropathy; it is the most frequent chronic complication of diabetes and more than half of the patients make this complication throughout their lives, both pathogenetic mechanisms and epidemiology, its diagnosis and treatment generate many controversy and challenges for both researchers and practitioners. The study batch consisted of 40 diabetic patients admitted to the Neurology Clinic of the Clinical Recovery Hospital and the Diabetes Clinic between January 2014 and December 2018 who were diagnosed according to clinical and electrophysiological criteria, the etiology of which was type II diabetes with a history of more than 5 years of development and who were examined the lower limb skin according to the local protocol. Thermography is already used as a diagnostic and monitoring tool for patients suffering from neuropathies, especially in the case of complex regional pain syndrome (sympathetic reflex dystrophy) and in our case of diabetic polyneuropathy. This non-invasive exploration has great potential for future research on its use in the diagnosis of other neurological diseases involving the peripheral nervous system. Medical imaging analysis provides a useful way to diagnose and monitor multiple physical illnesses; infrared imaging provides information about infrared energy from the surface of the skin. Emission of infrared radiation changes after nerve damage and vascular occlusions.
The Multisystemic Effect of Oestradiol Variations
Authors: Mihalceanu Elena , Calin Alina Mihaela , Debita Mihaela , Negru Dragos , Mitrea Geta , Negru Irina
Published: January 2020

Ovarian hormones are: oestrogenic hormone, also known as follicular hormone or female sexual hormone or chemically oestradiol; yellow body hormone, progestin or, chemically, progesterone. Oestrogenic hormone is particularly involved in the first part of the oestrus period, and the yellow body hormone in the second part (pseudo-pregnancy) and in the gestation state; the third ovarian hormone, known as relaxin, was isolated from the yellow body. Oestrogens are responsible for the development of female secondary features. Together with progesterone it controls the most important female reproductive processes. The most biologically active of oestrogens is 17b-oestradiol. Oestradiol is produced by ovarian follicles, testicles, but also by some organs such as the liver, adrenal glands, mammary glands and the brain. Oestradiol activates two specific nuclear proteins, oestrogen receptors alpha (ER�) and oestrogen receptors beta (Er�). Oestrogen receptors alpha are predominant in the mammary gland, genital apparatus, bone, nervous and cardiovascular system. Oestrogen receptors beta are found in the uterus, monocytes, tissue macrophages, colon and lung epithelial cells, epithelial cells of the prostate. The main actions of oestradiol are: endometrial proliferation, effects on the vagina and the mammary gland; it also has a role in preventing osteoporosis and reducing cardiovascular risk. Oestradiol is primarily produced in the ovary (the follicle, yellow body), but small amounts are also formed in the testicles and the cortex of the adrenals. In pregnancy, oestrogen is mainly produced by the placenta. Approximately 98% of oestradiol is linked to sex hormone binding globulin (SHBG). The level of oestradiol increases throughout the follicular phase of the menstrual cycle in close dependence with the growth and development of the ovarian follicle. For the determination of oestradiol, we conducted a study of 64 people, of which 47 women (73.43% and 17 men (26.57%). The presence of oestrogen receptors alpha indicates an increased risk of breast cancer. Breast cancer is hormone dependent, 74% of cases are oestrogen-positive receptors, and 30% of cases are progesterone-positive receptors. The main reason for the development of hyperplasia is the increase in oestrogen levels.
Bleeding Complications in Atrial Fibrillation Patients on Anticoagulant Therapy
Authors: Silivastru (Cozlea) Ionela , Keresztesi Gabriela , Keresztesi Arthur Atilla , Cozlea Daniel Laurentiu , Caldararu Carmen , Dobru Daniela Ecaterina
Published: January 2020

The risk of bleeding in atrial fibrillation patients on direct oral anticoagulant treatment increases with age; particularly dabigatran is associated with a higher risk of gastrointestinal bleeding in elderly patients, low body mass ([48 kg) and women due to the induced dyspepsia. We aimed to evaluate the safety of direct oral anticoagulants (DOAC) dabigatran, rivaroxaban and apixaban by comparing each agent with a widely used vitamin K antagonist (VKA)-acenocoumarol in terms of bleeding event rates. A retrospective study regarding bleeding events in atrial fibrillation patients treated with oral anticoagulation (OAC) was performed. Haematuria, epistaxis and haemoptysis were considered minor events and intracranial bleeding, gastrointestinal bleeding (superior or inferior), blood transfusion after haemorrhagic events linked to OAC treatment were considered to be major events. A number of 219 atrial fibrillation patients were included using electronic medical records: 118 patients treated with DOAC s (82 using dabigatran, 28 on rivaroxaban regimen and 8 cases treated with apixaban) and 101 cases had vitamin K antagonists treatment (acenocumarol). A total of 75 bleeding events were encountered (70 minor and 5 major). A higher number of events were encountered in patients treated with DOAC s, but with no statistically significant difference compared to acenocumarol. The associated risk factors did not play a decisive role in bleeding events in the two treatment groups. No statistical significant difference was noted between the occurrence of haemorrhagic events and the class of oral anticoagulant treatment used (DOAC vs. VKA).
The Role of Imaging Techniques in Diagnosing Pancreatic Cancer
Authors: Sas Lorena , Taisescu Oana , Taisescu Citto Iulian , Artene Stefan-Alexandru , Dumitra Gindrovel , Tudorache Stefania , Dricu Anica , Sas Teodor
Published: January 2020

Imaging techniques play an essential role in the diagnosis, staging and establishing the treatment protocols in pancreatic cancer. Our proposed study explores and improves recent discoveries in the field of pancreatic cancer, especially relying on complex imaging techniques such as Computer Tomography (CT), Nuclear Magnetic Resonance (MR 3T), Ultrasonography (US) and Endoscopic Ultrasonography (EUS). In the case of pancreatic tumors, regardless of their origin, imaging exams also allow the evaluation of local and distant extension, with important prognostic and treatment ramifications. CT exams alongside RM and EUS offer a highly sensible and specific diagnosis of pancreatic tumors, with the added advantage of concomitant evaluation of adjacent parenchymatous abdominal organs.
Open Carpal Tunnel Release:Performed Axillary Brachial Plexus Block vs. Wide Awake
Authors: Raducu Laura , Avino Adelaida , Cozma Cristina-Nicoleta , Balcangiu-Stroescu Andra-Elena , Timofte Delia , Tanasescu Maria Daniela , Balan Daniela Gabriela , Jecan Cristian-Radu , Ionescu Dorin
Published: January 2020

Ropivacaine and lidocaine are used in surgical anaesthesia for the upper extremety. The first one is indicated for the axillary brachial plexus block and the second one as an local anaesthetic. A retrospective study was realized to evaluate the differences between the two anaesthetic methods used for the carpal tunnel release.
Effect of Lead Toxicity on the Structure and Function of Organs in Rats
Authors: Mituletu Mihai , Filimon Marioara Nicoleta , Vlad Daliborca Cristiana , Cimporescu Adinela , Dumitrescu Eugenia , Dumitrescu Gabi , Nica Cristian , Sinitean Adrian , Verdes Doina
Published: January 2020

Acute and chronic exposure to lead induces oxidative damage and morphologic and physiological changes in tissues and organs. The aims of this study were to determine the concentration of heavy metals like Zn, Al, Li, Cu and Pb in different organs and to identify histopathological changes in the liver and kidneys of laboratory animals in case of chronic lead intoxication. In most cases, the heavy metal concentrations analyzed in the control group organs are significantly lower than the values determined in the organs in the experimental groups. High Pb concentration caused increased liver and kidney damage.
Cavitation Erosion Resistance Tests Performed on Some Stainless Steels for Turbine Runner Blades
Authors: Coman George , Pantilimon Mircea Cristian , Sohaciu Mirela Gabriela , Ciuca Sorin , Anton Marius Gabriel , Predescu Cristian , Dumitrescu Ruxandra Elena , Berbecaru Andrei Constantin , Gherghescu Ioana Arina
Published: January 2020

The paper presents cavitation erosion testing results of three stainless steels that may be used in making hydropower turbine parts. Two of these steels have a chemical composition close to that of some other stainless steels previously employed in producing these parts. They are updated steel grades of the former ones. The third one is newly conceived. Aiming better mechanical and corrosion resistance characteristics as well as an inclusion - free structural state, steels were produced in an induction furnace with cold copper crucible under vacuum and argon atmosphere. Quenching and tempering heat treatments were subsequently applied.
QRISK2 Score in CABG Patients Correlated with Risk Factors
Authors: Bazyani Amin , Namat Razan Al , Felea Maura Gabriela , Costache Irina Iuliana , Constantin Mihai , Sorodoc Victorita , Sorodoc Laurentiu , Simion Paul , Mihalcia Mirela Mihaela , Mitu Florin , Tinica Grigore
Published: January 2020

Guidelines for primary prevention suggested using any risk score, among those QRISK2, identifying the high-risk populations. The purpose of this study was to determine whether the QRISK2 Score would register changes in patients with coronary artery disease demanding acute or postponed CABG intervention. The QRISK2 Score was performed the day of admission after the clinical examination and blood test results, and immediately after CABG surgery (in the first week post-CABG, in an interval of 24 hours to 7 days) having another blood test evaluation. The 120 patients admitted in the Clinic of Cardiovascular Surgery of the Institute of Cardiovascular Disease met the inclusion criteria: CABG patients (less than 1 week), aged 40-85 years old, BMI ] 25 kg/m�, and mixed dyslipidemia. In both phases, for every patient, it was performed a clinical examination, a set of hematological, biochemical, lipid, coagulation and inflammatory profile, and ECG and echocardiography. Our research on hospitalized patients undergoing CABG, by comparing the Phase I and Phase III results, revealed that the median 10-year QRISK2 cardiovascular risk score was approximately 47.88 % lower (p=0.000) in the first week after cardiac surgery. QRISK2 score gives a more appropriate risk estimation based on the social component, thus identifying high risk patients associating social deprivation. Comparative to Framingham risk score, QRISK2 score, by including additional variables, proves the efficacy of lifestyle changes and management decisions, and sustaines the treatment directed towards modifying variables or risk factors.
Impact of Therapy with Selective Serotonine-Reuptake Inhibitors on the Evolution of Subclinical Atherosclerosis in Patients with Depressive Disorder
Authors: Tudoran Mariana , Giurgi-Oncu Catalina , Andor Bogdan , Awwad Ahmed Abu , Pop Gheorghe Nicusor , Berceanu-Vaduva Delia , Tudoran Cristina
Published: January 2020

The aim of this study is to highlight the impact of therapy with Sertraline on the AS alterations, in a group of 128 patients with MDD, but without significant CVD or risk factors for atherosclerosis. A secondary goal was to analyze whether there are statistically significant correlations between AS and the intensity of the current depressive episode, as assessed by using the Montgomery-Asberg Depression Rating Scale (MADRS), while also taking into account the duration of MDD.
Study on Antibiotic Loaded Nanoparticles for Oral Infection Treatment
Authors: Zegan Georgeta , Toma Vasilica , Cernei Eduard Radu , Anistoroaei Daniela , Carausu Elena Mihaela , Moscu Mihaela
Published: January 2020

Over the past decade, exploitation of antimicrobial effect of nanoparticles on viruses, fungi and bacteria, respectively have developed markedly. A close attention was received by the possibility of nanoparticles type drug delivery systems to limit the biofilm formation within the oral cavity due to their important properties such as delivery abilities, anti-adhesive and biocidal features. The major objective of this work was to obtain doxycycline-loaded chitosan nanoparticles and to analyze the properties of as prepared samples in order to prolong the antibiotic release. The synthesized nanoparticles had less than 100 nm using the classis or improved drug encapsulation technique in chitosan matrix. The study focused on the antimicrobial characteristic of nanoparticles for controlling oral infections.
Influence of Main Works Systems on Physical and Chemical Properties of the Soil
Authors: Muscalu (Plescan) Oana-Maria , Nedeff Valentin , Sandu Ioan Gabriel , Partal Elena , Mosnegutu Emilian , Barsan Narcis , Sandu Ion , Rusu Dragos
Published: January 2020

The purpose of this research have been to determine the influence of soil main works systems (no tillage, fall tillage, spring tillage, discing in) on the physical properties (penetration hardness, air speed in soil) and chemical properties (humidity, humus, total nitrogen, calcium, chlorides) of the soil. The experiments have been carried out in the experimental field of National Agricultural Research and Development Institute - Fundulea, Romania, for a corn monoculture. The highest values of the soil penetration hardness have been recorded for the corn monoculture for which the spring tillage system had been applied (4.9 MPa, working depth 15-30 cm). The lowest values of total nitrogen and chlorides content have been recorded for the corn monoculture for which the fall tillage system had been applied (1.37 mg/kg d.s., working depth 15-30 cm) in the case of the total nitrogen and for the corn monoculture - discing in system (4.43 mg/100g sol, working depth 0-15 cm).
Assessment of Cleaning Effect of Irrigation Time Using 5.25% Sodium Hypochlorite and Aspiration with Endovac
Authors: Devleminck Carina Andreea , Ionas Mona , Sarosi Codruta , Stef Laura
Published: January 2020

The aim of this study is to determine whether there is a link between the 5.25% sodium hypochlorite irrigation time using Endovac and the endodontic space cleaning quality. The study was done on teeth with a root length of more than 12 mm that did not undergo previous endodontic treatments and had a closed apex. All roots where mechanically prepared and the irrigation protocol was applied acording to the established protocol. The root canal surface was explored by electronic microscopy. A score was given to each image regarding remaining debris and smear layer. The comparative analysis of experimental data shows, that there are no statistically significant differences between the study groups regarding debris and smear layer removal. None of the techniques used in the present study has led to the complete removal of dentinal detritus and root smear layer.