bluuebunny/crossref_metadata_2025 huggingface dataset:
Terahertz spectroscopy detection of zinc citrate in flour and milk powder mixtures
Authors: Song Ziyu , Liao Min , Ling Dongxiong , Chen Changshui , Wei Dongshan
Published: August 2022

Zinc citrate (ZC) has been widely used in food as an important nutritional supplement. Accurate detection of ZC in food is important for health and safety. In this study, THz time-domain spectroscopy (THz-TDS) is used to quantitatively detect ZC in flour and milk powder mixtures. In our research, 15 different contents of ZC in flour and milk powder mixtures were prepared and measured by THz-TDS. A partial least squares (PLS) model was established based on the quantitative analysis of the absorption coefficient data of these two mixtures at 0.5–3.0 THz. The

R
2

and rms error (RMSE) given by the PLS model prediction were, respectively, 0.999 and 0.14% ZC in flour and 0.999 and 0.20% ZC in milk mixtures, indicating the predictions of the PLS model are in excellent agreement with the experimental measurements. The results show that combining THz-TDS with the PLS model can be used for accurate, quantitative analyses of ZC in food mixtures.
Nanosecond photonic integrated multicast switch for low-latency optical wireless data center networks
Authors: Zhang Shaojuan , Tessema Netsanet , Santana Henrique , Kraemer Rafael , Xue Xuwei , Tangdiongga Eduward , Calabretta Nicola
Published: August 2022

Optical wireless data center networks (OW-DCNs), featuring no cable complexity, low latency, and high throughput, are highly attractive for the next generation of DCNs, while photonic integration provides a compact, low-power, and low-cost solution. In this Letter, we propose a novel, to the best of our knowledge, OW-DCN architecture using photonic integrated multicast switches (PIC-MCSs) to realize fast optical switching and multicast operation between top-of-the-rack switches (ToRs). By properly turning on/off the transmission channels of a semiconductor optical amplifier (SOA)-based PIC-MCS, the optical signals are directed to different target ToRs via arrayed waveguide grating routers (AWGRs) and free-space links. A 4×2 PIC-MCS with lossless multicast operation has been designed and fabricated. An OW-DCN of 4×4 interconnected racks has been experimentally demonstrated with the chip and a 4×4 AWGR. The results confirm the performance of low-latency switching, dynamic bandwidth reallocation, and WDM multicast transmission. Error-free operation at 10 Gb/s OOK with a power penalty of less than 1 dB is achieved, showing a negligible impact of cross talk on the PIC-MCS.
Explicating the responses of NDVI and GDP to the poverty alleviation policy in poverty areas of China in the 21st century
Authors: Fan ZeMeng , Bai XuYang , Zhao Na
Published: August 2022

The economy in the poverty-stricken areas of China has grown rapidly in response to poverty alleviation policies in the 21st century. To explicate the response of the eco-environment to rapid economic growth in the 14 contiguous areas of dire poverty in China, we developed a method of evaluating the impact of poverty alleviation policies on ecological health. Based on the yearly data of gross domestic product (GDP) per capita and normalized difference vegetation index (NDVI) from 2000 to 2019, the dynamic changes in NDVI and GDP were calculated, and the development patterns in the 14 contiguous areas of dire poverty were evaluated and classified. The results show that both annual GDP per capita and average annual NDVI exhibited an increasing trend, increasing by 43.81% and 0.84% per year, respectively. The development of the 14 contiguous areas of dire poverty all presented a coordinated and sustainable (A) development pattern during the period from 2000 to 2019. The consistency of economic and ecological health development between 2000 and 2013 was less than that between 2014 and 2019. Moreover, the result indicates that it is necessary to make timely adjustments to poverty alleviation strategies based on the positive consistency between economic growth and ecological health.
The role of irrational beliefs and motivation regulation in worker mental health and work engagement: A latent profile analysis
Authors: Turner Martin , Miller Anthony , Youngs Hope
Published: August 2022

Research concerning rational emotive behaviour therapy (REBT) and autonomous and controlled motivation within athletic settings is burgeoning. It is proposed that irrational beliefs (i.e., illogical, rigid, and extreme) together with controlled forms of motivation, can determine psychological well-being and physical health in these contexts. For example, research indicates that extreme negative self-evaluation (i.e., self-depreciation) is related to more controlled (less autonomous) motivation regulation, which may underpin poorer health. Though, research is yet to understand the concomitant influence of both irrational beliefs and motivation regulation on work related variables such as presenteeism, persistence and turnover intention, as well as non-work-related variables such as life satisfaction and mental-wellbeing. The present two study paper examines the latent profile structure of irrational beliefs and motivation regulation, and how these latent profiles relate to health and work-related variables. Across studies 1 and 2, results indicated a two-class profile whereby class 1 is characterised by low irrational beliefs and high self-determined motivation (low irrational engagement), and class 2 is characterised by high irrational beliefs and low self-determined motivation (high irrational engagement). Those in Class 2 reported poorer life satisfaction, persistence, and presenteeism, as well as greater depression, anxiety, stress, intention to quit, and absenteeism than those in class 1. Thus, findings indicate that poorer work and health outcomes are associated with greater irrational work engagement. The findings are discussed in relation to the practical implications for occupational workers.
Computability theory as aphilosophicalachievement
Authors: Plebani Matteo , San Mauro Luca
Published: August 2022

Artificial intelligence plays an important role in contemporary medicine. In this short note, we emphasize that philosophy played a role in the development of artificial intelligence. We argue that research in computability theory, the theoretical foundation of modern computer science, was motivated by a philosophical question: can we characterize precisely the class of problems that can be solved by algorithms? We suggest that reflecting on the connection between philosophy and artificial intelligence helps realize that philosophical and scientific progress are connected.
Field Survey in the Middle Fortore Valley: A Preliminary Report
Authors: Naso Alessandro , De Simone Claudio Sossio , Esposito Maria Pia
Published: August 2022

The Fortore Valley Project, which began in 2005 and is still ongoing, aims to create an archaeological map of the Fortore Valley. Several intensive and extensive survey campaigns were carried out in the territory of the middle valley. More than 100 km2 have been surveyed and more than 300 sites identified. This contribution analyzes the collected data and proposes a model of population evolution based on a GIS spatial analysis and a preliminary study of the finds. The artifacts found between 2005 and 2006 in the territory of Occhito Lake (Macchia Valfortore) provide a case study for understanding settlement patterns in the Fortore Valley.
Processo de trabalho e sofrimento institucional em Centros de Atenção Psicossocial Infanto-juvenis (Capsi): uma pesquisa-intervenção junto a trabalhadores
Authors: Bustamante Vania , Onocko-Campos Rosana
Published: August 2022

Esta avaliação participativa junto a trabalhadores dos Centros de Atenção Psicossocial Infantojuvenil de um município de grande porte do sudeste brasileiro enfoca o processo de trabalho e sua relação com o sofrimento institucional, na perspectiva de René Käes. O curso ofertado para tal envolveu a construção e validação de narrativas junto a trabalhadores, pactuação de indicadores de avaliação e um guia de boas práticas. Os trabalhadores expressaram modalidades de sofrimento institucional relacionadas com: condições de trabalho, relações na instituição, falta de espaço de diálogo e formação permanente, como a supervisão clínico-institucional. Manifestaram ainda uma importante identificação com os valores das reformas sanitária e psiquiátrica e com a história peculiar das políticas de saúde no município, que contribuiu para a manutenção do que Onocko-Campos denomina “ilusão institucional”.
ANALOGICAL REASONING IN MULTIPLE SCLEROSIS
Authors: DOĞAN ÜNLÜ Melike , DEMİRCİ Serpil
Published: August 2022

Objective Cognitive impairment is common in multiple sclerosis (MS) and occurs at all stages of the disease with a significant negative effect on daily life activities, vocation, social relationships and quality of life. Analogical reasoning involves identifying a common relational system between two situations and then generating further inferences driven by these shared commonalities that is a fundamental aspect of human cognition people routinely use in everyday life, in a wide range of problem-solving contexts and decision making. The aim of the study is to evaluate analogical reasoning skills in individuals with MS. Material and Method This observational case-control study covers 30 MS patients without any cognitive complaint and 30 age-, sex- and education-matched healthy person. All participants were underwent a thorough neuropsychological evaluation with emphasis on working memory, attention, executive functions and concept formation and analogical reasoning. Results MS patients’ performance on working memory, attention and executive functions were worse in comparison to the control group. In general no difference was observed regarding concept formation, abstraction, cognitive flexibility and analogical reasoning between MS patients and healthy controls. However MS patients with advanced age exhibited a poor performance in these tasks which also showed a moderate correlation with disease duration. Conclusion Cognitive dysfunction can be detected even in MS patients who are relatively young and have low disability, without any cognitive complaints. Although early cognitive reserves are sufficient for performance in analogical reasoning tasks similar to that of healthy controls, they show significant deterioration with advancing age.
Breakthrough COVID-19 infection according to the infectious diseases hospital
Authors: Galiullina Milyausha Sh. , Khaliullina Svetlana V. , Khaertynov Khalit S. , Gataullin Marat R. , Martynova Tatyana M. , Anokhin Vladimir A.
Published: August 2022

Background. Despite the obvious successes of the world community in the fight against the spread of SARS-CoV-2, attempts to create new drugs that are active against the COVID-19 pathogen do not stop. In parallel, a targeted search for new prevention opportunities is being carried out. Vaccination does not protect 100% against possible infection, but significantly reduces the risk of developing severe forms of COVID-19, the need for hospitalization and death.
Aim. Describe the course of COVID-19 in patients previously vaccinated against this infection.
Material and methods. On the basis of the Republican Clinical Infectious Diseases Hospital of Kazan, from January 15 to August 28, 2021, an observational retrospective analytical study, which included the observation of 1260 patients who applied to the emergency room of the hospital and had a history of immunization against COVID-19, was conducted. Statistical data processing was carried out using an on-line calculator. The significance of differences between the compared groups was calculated using the 2 test and Fisher's exact test. Gam-COVID-Vac as a specific prophylaxis was received by 87.8% (1106/1260), EpiVacCorona by 9.5% (120/1260), CoviVac by 2.6% (33/1260), Sputnik Light by 0.1% (1/1260). The assessment of adverse events after immunization was carried out taking into account the recommendations of the World Health Organization (2012).
Results. Laboratory-confirmed (or clinico-epidemiologically) new coronavirus infection was registered in 53.4% (673/1260) of patients. The proportion of cases of COVID-19 in each group vaccinated with a particular vaccine differed: among those vaccinated with Sputnik V it was 51.3% (567 people out of 1106 who applied), with EpiVacCorona 71.7% (86 out of 120; p 0.001), KoviVak 62.5% (20 out of 32). Side effects after immunization due to the action of the vaccine (previously such phenomena were called post-vaccination reactions) were registered in 1% (12/1260) of the vaccinated. Breakthrough infection (developing 14 days after the completed vaccination course) was recorded in 26.4% (333 out of 1260). It was characterized by a milder course and minimal manifestations on computed tomograms. The highest epidemiological efficacy among the three domestic vaccines (Gam-COVID-Vac, EpiVacCorona and KoviVac), according to our results, was shown by Gam-COVID-Vac. Those vaccinated with it fell ill with COVID-19 less frequently (33%, 365/1106) than those vaccinated with EpiVacCorona (56.7%, 68/120) and CoviVac (31.3%, 10/32), p 0.001 and p=0.836, respectively.
Conclusion. Breakthrough COVID-19 infection was characterized by a milder course, even among hospitalized patients, exceptionally low mortality rate (0.9%, 3/333) in vaccinated compared to unvaccinated against SARS-CoV-2. Our study has shown that a full course of immunization reduces the incidence of moderate and severe forms of the disease.
Predicting outcomes of in vitro fertilization in women with infertility
Authors: Ismayilova Mahira K.
Published: August 2022

Background. The development of predictors of the infertility treatment effectiveness by in vitro fertilization is one of the most important tasks of modern medicine. Despite numerous studies, there is still no single point of view regarding the significance of the influence of certain factors on the in vitro fertilization results.
Aim. Creation of a predictive model for the outcomes of in vitro fertilization for women suffering from infertility.
Material and methods. A retrospective analysis of 518 case histories of patients suffering from infertility and undergoing an in vitro fertilization program from 2015 to 2020 at the Central Clinic in Baku was carried out. Of these, 234 women (main group) became pregnant after in vitro fertilization, while 284 (control group) did not. Due to this, an individual card and an algorithm for examining patients in order to predict the results of in vitro fertilization were developed. At the prospective stage of the work, the results were predicted using logistic regression analysis. The data obtained from clinical and laboratory studies were processed by the methods of variational statistics in the statistical analysis system Statistica 10. The KolmogorovSmirnov, ShapiroWilkie, and Leven tests were used. For comparative analysis, Student's t-test and the MannWhitney method were applied.
Results. Based on the model we proposed using logistic regression, the main predictors of in vitro fertilization outcomes were identified: the absence of a previous pregnancy, the outcome of previous pregnancies with secondary infertility, age, spontaneous loss of uterine pregnancy, previous in vitro fertilization with a live birth, the number of mature oocytes prior to assisted reproductive technology and the number good quality embryos on the day of transfer. The sensitivity of this forecast was 84.7% (61 and 9; p=0.000), the specificity was 88.8% (11 and 72; p=0.000). It was found that forecasting using the model is 44.3 times more correct than if the prognosis of the outcome of in vitro fertilization was performed randomly.
Conclusion. The developed logistic regression forecasting model allows in the vast majority of cases to correctly predict the outcome of in vitro fertilization.
Pathological manifestations of inflammatory microthrombosis in COVID-19
Authors: Khismatullin Rafael R. , Ivaeva Rozalina A. , Abdullayeva Shahnoza , Shakirova Asia Z. , Khuzin Felix F. , Kiassov Andrei P. , Litvinov Rustem I.
Published: August 2022

Background. COVID-19 is a predominantly respiratory disease caused by the SARS-CoV-2 virus that has spread as a pandemic since 2020; characterized by high mortality and unexplored long-term outcomes.
Aim. To describe the morphological changes in the lungs and other organs in severe forms of COVID-19.
Material and methods. A macro- and microscopic examination of the lungs, kidneys, liver, brain and heart of 45 patients who died from complications of COVID-19 was carried out. Histological preparations were stained with hematoxylin and eosin, by the Picro-Mallory stain, as well as with fluorescent antibodies and dyes to visualize neutrophil extracellular traps.
Results. The leading pathomorphological manifestations of COVID-19 were inflammation and microthrombosis in the lungs. At the same time, diffuse alveolar damage often developed as a manifestation of acute respiratory distress syndrome in an adult. Diffuse leukocyte infiltration of the lungs was combined with the formation of neutrophil extracellular traps in the lumens of the blood vessels. Diffuse microthrombi were found in most lung tissue samples (87%), while macroscopic thrombi were much less common (16%). In single cases, the cause of death was thromboembolism of the branches of the pulmonary artery, originating from deep vein thrombi of the lower extremities or the right atrial appendage. In the tissues of the liver, heart, kidneys and brain, moderate alterative (degenerative and necrobiotic) microscopic changes were observed, as well as morphological signs of concomitant chronic diseases.
Conclusion. COVID-19 is characterized by pathogenically interrelated morphological manifestations of inflammation and primary pulmonary (micro)thrombosis in the form of accumulation of leukocytes both in blood clots and in the alveoli, while regional pulmonary immunothrombosis is associated with diffuse damage to the alveoli; in the heart, brain, liver and kidneys, predominantly dystrophic and necrobiotic changes occur, which are typical of secondary injuries and/or concomitant pathology.
Analysis of the association of FTO, PPARG and PPARGC1A gene polymorphisms with carbohydrate metabolism disorders
Authors: Valeeva Farida V. , Khasanova Kamilya B. , Sozinova Elizaveta A. , Kiseleva Tatyana A. , Valeeva Elena V. , Egorova Emiliya S. , Ahmetov Ildus I.
Published: August 2022

Background. Conducting molecular and genetic studies to investigate susceptibility to multifactorial and polygenic diseases, such as type 2 diabetes melitus and pre-diabetic conditions, is of great importance for the development of personalized prevention programs and the choice of optimal treatment. Taking into account regional and ethnic features, the study of polymorphic markers of candidate genes for fat and carbohydrate metabolism has a great practical value.
Aim. To investigate associations of polymorphisms of the FTO rs9939609, PPARG rs180128, PPARGC1A rs8192678 genes with the risk of developing type 2 diabetes mellitus and pre-diabetic conditions in residents of the Republic of Tatarstan.
Material and methods. An observational single-stage single-center controlled study was conducted in patients with various disorders of carbohydrate metabolism: prediabetes (n=138) and a confirmed diagnosis of type 2 diabetes mellitus (n=134). Molecular genetic analysis of rs9939609 polymorphism of the FTO gene, rs8192678 polymorphism of the PPARGC1A gene and rs1801282 polymorphism of the PPARG gene was performed using real-time polymerase chain reaction. The distribution of patient genotypes and alleles was compared with the Russian population. Statistical data processing included nonparametric correlation analysis using Pearsons coefficient, calculation of Student's and 2 tests, odds ratios, arithmetic mean values and their standard deviations using GraphPad InStat software.
Results. The A allele of the rs9939609 polymorphism of FTO gene increases the risk of developing type 2 diabetes mellitus and early carbohydrate metabolism disorders (OR=2.73, p=0.00007 and OR=4.17; p=0.00002, respectively). The GG genotype of the rs180128 polymorphism of the PPARG gene is associated with the risk of type 2 diabetes mellitus (OR=2.77, p=0.02).
Conclusion. The expected association of the rs9939609 FTO polymorphic marker, which determines the development of insulin resistance, with the development of type 2 diabetes mellitus and the presence of early carbohydrate metabolism disorders was obtained.
Recognition of mutant forms of the sodium-dependent phosphate transporter NaPi2b by ­monoclonal antibodies in ovarian cancer cells
Authors: Bulatova Leisan F. , Skripova Vera S. , Korotaeva Arina V. , Bogdanov Mikhail V. , Kiyamova Ramziya G.
Published: August 2022

Background. The sodium-dependent phosphate transporter NaPi2b is expressed in a number of tumors and serves as a target for monoclonal antibody therapy. The NaPi2b transporter has a large extracellular domain containing 4 cysteines and an MX35 epitope recognized by the corresponding monoclonal antibodies.
Aim. To study the recognition of the MX35 epitope in cysteine mutants C303 and C350 of the sodium-dependent phosphate transporter NaPi2b by monoclonal antibodies in ovarian cancer cells.
Material and methods. Ovarian cancer cells of the OVCAR-8 line were transfected with plasmids encoding mutant forms of the NaPi2b transporter. The recognition of these forms by monoclonal antibodies was studied by Western blot and flow cytometry. Statistical analysis of flow cytometry data was performed using Pearsons Chi-squared test with Yates correction.
Results. Western blot analysis of lysates of OVCAR-8 cells expressing the wild-type NaPi2b transporter demonstrated the presence of a specific signal only in samples without the addition of dithiothreitol, while in all samples with NaPi2b cysteine mutants, even without the addition of dithiothreitol, no specific signal from monoclonal antibodies was detected. The flow cytometry results showed that proportion of OVCAR-8 cells with positive staining of the MX35 epitope with antibodies is less when expressing the NaPi2b mutants compared to the wild type.
Conclusion. Cysteines C303 and C350 are involved in disulfide bonds formation, which is of key importance for the formation of the conformation of the extracellular domain of the sodium-dependent phosphate transporter NaPi2b, which ensures the MX35 epitope recognition by monoclonal antibodies.
Alfred Ernestovich Ozol — a vivid example of selfless service to science (to the 130th anniversary of his birth)
Authors: Isaeva Guzel Sh.
Published: August 2022

The article was prepared for the 130th anniversary of the head of the Departments of Microbiology and Epidemiology of the Kazan Medical Institute, Professor Alfred Ernestovich Ozol. The article presents the main milestones of the biography of A.E. Ozol, a prominent representative of the Voronezh and Kazan schools of epidemiologists and microbiologists. Materials on the contribution of A.E. Ozol to the elimination of epidemics and outbreaks of infectious diseases: typhus, anthrax, tularemia, brucellosis, smallpox, diphtheria, typhoid fever, dysentery in the Soviet period are presented. The main scientific achievements of A.E. Ozol and his contribution to the development of microbiology and epidemiology, data on his role in the development of the epidemiological direction of the Kazan Research Institute of Epidemiology and Microbiology are described. The article was prepared using primary sources scientific articles and monographs published during his activity, a personal file from the archive of the personnel department and materials of the Department of Microbiology named after academician V.M. Aristovsky of Kazan State Medical University, as well as the personal archive of the family of A.E. Ozol.
Delayed asymptomatic blunt traumatic diaphragmatic hernia: an unusual case report
Authors: Revata Cylla , Rahmansyah Mulia
Published: August 2022

IntroductionTraumatic diaphragmatic hernia (TDH) is uncommon, being encountered in around 0.8%-8% of patients with blunt abdominal trauma. Severe comorbidities such as fractures and thoraco-abdominal or head injuries that accompany TDH, are responsible for poor prognosis and often mask diaphragmatic injury itself. Objective of this case report was to highlight rare blunt TDH case to avoid missed diagnosis leading to complications.
Case descriptionSixty seven-year old man presenting with right chest pain without difficulty of breathing after falling from stairs 1 hour before hospital admission. On clinical examination, vitals were stable, but with decreased breath sounds on right lower side of chest. Patient had history of trauma from being crushed by elevator 40 years ago without any proven diaphragmatic injury. Initial erect chest X-ray findings were inhomogeneous opacity shadow on lower right hemithorax suspected to be diaphragmatic hernia and 7th right rib fracture with pleural effusion. Thorax CT scan showed herniated right lobe of liver, gall bladder, and mesenteric fat on right hemithorax causing displacement of mediastinal structures. Patient was diagnosed with delayed TDH and hemothorax caused by newly fractured rib. Patient was referred to a better-equipped facility due to the limited surgical facilities in referring hospital.
ConclusionDelayed TDHs are not common, but can lead to serious consequences. Blunt TDH occurs more often on left than on right side, in ratio of approximately 3:1. Traumatic diaphragmatic hernia is sometimes diagnosed many years after traumatic event due to latent phase of disease possibly ranging from days to years.
Optimal profit and transaction costs for a production function with variable elasticity of output with resources
Authors: Ilyina Elena A. , Saraev Leonid A.
Published: August 2022

The published article examines the influence of non-production (transactional) costs of a multifactorial manufacturing enterprise on the formation of its profit. An economic-mathematical model for calculating the profit of an enterprise is proposed, the production function of which takes into account changes in the values of elasticity for each resource, and production (transformation) and non-production (transactional) costs are also described by an exponential function. The features of the formation of profit volumes in the short-term and long-term periods of the enterprise's work are studied. A variant of the calculation model of the maximum possible profit, ignoring the role of transaction costs, and a variant of the calculation model of optimal profit, taking into account the influence of transaction costs, are obtained. The source of transaction costs is the costs of market transactions, for the implementation of which it is necessary to find a subject interested in concluding a transaction, conduct preliminary negotiations with him, prepare a contract and conditions for its implementation, etc. The resources and costs required for all this are the essence of the transaction costs of concluding a deal. It is shown that when calculating the volume of emerging profit, it is necessary to maximize not only the profit function itself, but also the transaction utility function. Numerical analysis of the results of calculations shows the unattainability of the maximum possible values of profit, since in practice the management of the enterprise maximizes not the profit itself, but its utility, expressed as the corresponding transactional function.
Influence of transport and logistics complex on the economy of the Samara Region
Authors: Uvarova Lada A.
Published: August 2022

: Transport plays an important role in the development of the economy of the region and the country. Creating conditions for the efficient operation of transport and the provision of logistics services is one of the priorities for the Government of the Russian Federation. Transport and logistics complexes of the regions ensure the availability of transport services to the population, the movement of goods along transport corridors, the use of modes of transport, the possibility of warehousing and storage of goods. Thanks to the development of transport network and the smooth operation of transport processes, the functioning of the region's economy is ensured, which has a positive effect on the overall economic growth of the national economy. The paper reveals the concept of transport and logistics complex, its features and functions. A universal model of development of transport and logistics complex of the region is proposed, which takes into account the elements of transport and logistics complex and the directions of its development depending on territorial, resource, social factors and state regulation. The article substantiates the mutual influence of transport and logistics complex and the economy of the region. The article presents an econometric model for assessing the parameters of transport systems, which determines the interdependence of socio-economic indicators of the region and indicators of transport and logistics complex. In the study, the indicators of transport and logistics complex that have the greatest impact on the gross regional product are determined, and the equations of the gross regional product are obtained, in which the indicators that have the greatest impact on its formation are presented. The economic justification of the dependence of indicators of transport and logistics complex and the gross regional product is presented. The negative dependence of the region's economy on the number of road accidents, the operational length of highways with hard and improved pavement, as well as a paradoxical negative dependence on the turnover of motor transport has been revealed.
Directions for preserving the economic security of the regions using the cluster approach
Authors: Kliment’yeva Svetlana V.
Published: August 2022

In the economic space, the one who has managed to create key competencies and produce competitive processes and products wins. In turn, competitiveness in the modern economy is achieved due to the increase in the level of innovativeness of developments, which directly depends on the investment opportunities of the actors of economic relations and the conditions of macro- and microenvironment of management. In the new political and economic conditions, the most important thing is to maintain the achieved level of competitiveness of regional economies and the potential for its further development, which will make it possible not to lose economic security in the future as an element of the national security of state. One of the leading forms of associations in regional economies has been the creation and operation of economic clusters of various types, combining private initiative, state support, and scientific and educational component. The cluster approach has shown its effectiveness both on a global scale and at the regional level of the Russian Federation. In this regard, it is proposed to continue its use at the current stage of Russia's development and proposals are made that are designed to maintain positive trends in regional development and preserve the economic security of Russian regions based on the cluster approach.
Methodological aspects of the formation of a mechanism for implementing the strategy of innovative development at the regional level
Authors: Mironova Elena A. , Chebykina Marina V. , Shatalova Tatyana N.
Published: August 2022

The article is devoted to the study of various aspects of the formation of innovative strategies for the economic development of regions. The authors presented several variants of the definitions of the innovation strategy, essentially compared and analyzed them. Various approaches to the definition of the concept of economic strategy were considered, including G. Hamel and K.K. Prahalada, M.Yu. Porter, C. Macmillan, M.Mescon and A. Chandlenr, on their basis the author's definition was formed. Abstracts were formulated and the algorithms used to create a correct innovative strategy at the regional level were determined. The authors considered the structure of the region's innovation strategy as a connected system, identified key sections and provided explanations for them. The grouping of innovative potentials into 3 groups was also briefly described: the coefficients of promising opportunities, the resulting coefficients, as well as the request for innovative coefficients. The system of principles for the formation of the mechanism for implementing the strategy of innovative development of the region was graphically presented. In addition, the article described the structural elements of the mechanism for implementing the innovation development strategy at the regional level, including the mechanisms for creating conditions for interregional cooperation in the innovation sphere, mechanisms for financing innovation activities in the region, and mechanisms for improving the efficiency of the regional innovation process.
Efeitos do salário mínimo na dinâmica do emprego formal e informal no Brasil
Authors: Cardoso Adalberto
Published: August 2022

O artigo constrói hipóteses sobre a relação entre salário mínimo, emprego formal, emprego informal e transições ocupacionais no mercado de trabalho assalariado brasileiro. Contesta a teoria segundo a qual o aumento real do salário mínimo gera desemprego e/ou informalidade, trazendo evidências de que, ao contrário, o salário mínimo, a partir de determinado patamar considerado adequado pelos assalariados informais, atrai esses trabalhadores, com isso reduzindo a informalidade, em particular em conjunturas de expansão do emprego formal, como a vivida pelo Brasil entre 2003 e 2014. Traz evidências, também, de que o salário mínimo, ao aumentar em termos reais, tem um “efeito arrasto” sobre os demais salários de empregados formais, cujos valores aumentam por mecanismos discutidos no texto.
Evaluation of Factors Affecting Energy Aspects of Apple Slices by Response Surface Methodology in Convective Drying
Authors: ÇETİN Necati
Published: August 2022

Bu çalışmada, konvektif kurutmanın iki farklı elma çeşidinin (Granny Smith ve Red Delicious) kurutulmasında, kurutma sıcaklığı (50, 55 ve 60°C), numune kalınlığı (5, 7 ve 9 mm) ve kuruma süresi (8, 9 ve 10 saat) gibi bağımsız değişkenlerin özgül enerji tüketimi, özgül nem çekme oranı, enerji verimliliği, termal etkinlik ve efektif nem difüzyonu özelliklerine etkisi incelenmiştir. Bulgulara göre, ikinci derece polinom denklemlerinin yanıt değişkenlerini temsil etmede başarılı olduğu tespit edilmiştir. Ayrıca ANOVA sonuçlarına göre bağımsız değişkenlerin yanıt değişkenleri üzerinde istatistiksel olarak önemli seviyede etkili olduğu belirlenmiştir (p
Genetic Association of MSTN Variant (18:66493737T>C) with Racing Performance & Muscle Development in Pakistani Horses
Authors: Saif Rashid , Raza Muhammad Hassan , Zafar Muhammad Osama , Tariq Wajeeha , Ahmad Muhammad Danish , Wasim Muhammad
Published: August 2022

The horse is renowned for its racing performance, gaitedness, dancing and other personality traits. On the bases of these aesthetic characteristics, this valued species of Equus caballus is an integral part of different sports. A number of studies showing its racing performance is associated with MSTN gene in different horse populations of the world. So, the current study aimed to explore the genetic variability of 18:66493737T>C variant in the Pakistani random-bred horse population too. ARMS-PCR was used to genotype a total of 24 horses taken from equine clinics. Our initial results showed that overall, 54% population is homozygous wild type (TT), 41% is heterozygous (TC) and the remaining 4% is homozygous mutant (CC) at this locus. Alternative allele frequency within the best performers and control horses was 0.36 & 0.12 respectively. Similarly, Chi-Square association test was applied using PLINK data toolset which gave us a significant p-value of 7.832 × 10-6. Hence, the Pakistani horse population also proposes the variability of this locus in conformity to other horse populations of the world. Furthermore, similar studies may also be intended with racing performance data to evaluate different indigenous horse breeds with a large sample size, and subject marker may be propagated to other breeds by adopting targeted breeding strategies.
Hitting two BSM particles with one lepton-jet: search for a top partner decaying to a dark photon, resulting in a lepton-jet
Authors: du Plessis Karien , Flores M. M. , Kar Deepak , Sinha Sukanya , van der Schyf Hannah
Published: August 2022

A maverick top partner model, decaying to a dark photon was suggested
in Ref. [1]. The dark photon decays to two overlapping electrons for
dark photon masses of \approx 100≈100 MeV,
and results in a so-called lepton-jet. The event includes a top quark as
well, which results in events with two boosted objects, one heavy and
the other light. We propose a search strategy exploiting the unique
signal topology. We show that for a set of kinematic selections, both in
hadronic and leptonic decay channel of the SM top quark, almost all
background can be eliminated, leaving enough signal events up to top
partner mass of about 3.5 TeV for the search to be viable at the LHC Run
2. Further, integrated luminosity needed for the proposed search to be
sensitive is presented as a function of top partner mass.
Laser excitation of the 1s-hyperfine transition in muonic hydrogen
Authors: Amaro Pedro , Adamczak A. , Abdou Ahmed M. , Affolter L. , Amaro F. D. , Carvalho Patricia , Chen T. -L. , Fernandes L. M. P. , Ferro M. , Goeldi D. , Graf T. , Guerra M. , Hänsch Theodor , Henriques C. A. O. , Huang Y. -C. , Indelicato P. , Kara O. , Kirch Klaus , Knecht Andreas , Kottmann Franz , Liu Y. -W. , Machado Jorge , Marszalek M. , Mano R. D. P. , Monteiro C. M. B. , Nez F. , Nuber J. , Ouf A. , Paul N. , Pohl Randolf , Rapisarda E. , dos Santos J. M. F. , Santos J. P. , Silva P. A. O. C. , Sinkunaite L. , Shy J. -T. , Schuhmann K. , Rajamohanan S. , Soter Anna , Sustelo L. , Taqqu David , Wang L. -B. , Wauters Frederik , Yzombard P. , Zeyen M. , Antognini Aldo
Published: August 2022

The CREMA collaboration is pursuing a measurement of the ground-state
hyperfine splitting (HFS) in muonic hydrogen
(\muμp)
with 1 ppm accuracy by means of pulsed laser spectroscopy to determine
the two-photon-exchange contribution with 2\times10^{-4}2×10−4
relative accuracy. In the proposed experiment, the
\muμp
atom undergoes a laser excitation from the singlet hyperfine state to
the triplet hyperfine state, then is quenched back to the singlet
state by an inelastic collision with a H_22
molecule. The resulting increase of kinetic energy after the collisional
deexcitation is used as a signature of a successful laser transition
between hyperfine states. In this paper, we calculate the combined
probability that a \muμp
atom initially in the singlet hyperfine state undergoes a laser
excitation to the triplet state followed by a collisional-induced
deexcitation back to the singlet state. This combined probability has
been computed using the optical Bloch equations including the inelastic
and elastic collisions. Omitting the decoherence effects caused by the
laser bandwidth and collisions would overestimate the transition
probability by more than a factor of two in the experimental
conditions. Moreover, we also account for Doppler effects and provide
the matrix element, the saturation fluence, the elastic and inelastic
collision rates for the singlet and triplet states, and the resonance
linewidth. This calculation thus quantifies one of the key unknowns of
the HFS experiment, leading to a precise definition of the requirements
for the laser system and to an optimization of the hydrogen gas target
where \muμp
is formed and the laser spectroscopy will occur.
The microbiome of patients with irritable bowel syndrome: pathophysiology and applied aspects
Authors: Korochanskaya N. V.
Published: August 2022

Irritable bowel syndrome is a clinically and socially significant disease. The pathophysiology, the clinical manifestations of this disease and the  prognosis for  the patient are closely related to dysbiotic disorders of  the intestine. This review summarizes the ideas about changes in the intestinal microbiome in patients with irritable bowel syndrome. The pathogenetically substantiated approaches to the correction of dysbiosis that improving treatment outcomes are also considered. The results of the FLORAVIE clinical trial, which were discussed at the Expert Council “Identification of indications for prescribing probiotics in patients with irritable bowel syndrome” on March 18, 2022, are presented. Members of the Expert Council, Russian and international clinical guidelines emphasize the relevance of targeted probiotics administration. It was noticed that only strain specificity allows predicting a positive clinical response and has a certain evidence base. In this regard, the FLORAVIE study, conducted in real clinical practice in patients with predominantly severe forms of irritable bowel syndrome, is clinically relevant. It has been demonstrated that 30-day administration of the B. longum 35624 probiotic has reduced the severity of irritable bowel syndrome and has improved the quality of life in all subgroups of patients, especially in those with the most severe form of the disease. The data presented indicate that the inclusion of probiotic strains with proven mechanism of action in the complex therapy of irritable bowel syndrome can lead to the transformation of the course of the disease and improve the quality of life of patients. The high level of evidence made it possible to introduce the probiotic strain Bifidobacterium longum 35624 into a number of domestic and foreign guidelines.
Alternative therapies for recurrent cystitis in menopausal women
Authors: Kulchavenya E. V. , Treyvish L. S. , Telina E. V.
Published: August 2022

Worldwide, urinary tract infections (UTIs) are reported in 150-250 million people per year. Annual direct and indirect costs of UTIs for overall patients are estimated to be from $2.4 billion to $3.5 billion Uropathogenic Escherichia coli is the most common cause of UTIs. These bacteria have the ability to colonize urothelium, persist in epithelial cells, and form quiescent biofilms. This bacterial reservoir may provide a source for bacterial persistence and UTIs recurrence. Besides, recurrent UTIs may be caused by the translocation of other bacteria which originate from the gastrointestinal tract or reinfections due to external sources. Menopause and pregnancy are considered as complicating factors that predispose to UTIs. Oral vaccine OM-89 and D-mannose are specified in the European Urological Association guidelines among non-pharmacological methods for the prevention of recurrent UTIs in postmenopausal women. The rationale to the use of D-mannose in UTI prophylaxis is based on its competitive inhibition of bacterial adherence to urothelial cells due to binding of type 1 fimbriae expressed on the bacteria. Exogenous D-mannose is absorbed, but not metabolized by the human body and it is excreted intact in urine. In vivo and in vitro studies showed the ability of mannose-like molecules to provide a 2-fold reduction of bacterial load in the urinary tract after 4 intravesical instillations. Clinical studies also demonstrated a high efficacy of the six months course of oral mannose in the prevention of UTIs.
The effect of a new coronavirus infection caused by the SARS-CoV-2 virus on microcirculation in the conjunctiva
Authors: Safonova T. N. , Zaitseva G. V. , Kintyukhina N. P.
Published: August 2022

Introduction. The availability of an objective assessment of the microcirculatory bed is possible when examining the vessels of the conjunctiva. This is especially true in individuals who have had COVID-19 and have diseases associated with endothelial dysfunction.

Aim. To study the microcirculation in the conjunctiva after a new coronavirus infection caused by the SARS-CoV-2 virus.

Materials and methods. 83 patients with a history of coronavirus infection were examined. Patients were divided into 2 groups depending on the presence or absence of comorbidities. Group 1 patients (n = 42) with post-COVID changes in the conjunctiva (severe  injection of  the eyeball, chemosis, microhemorrhagia, folliculosis of  the tarsal and bulbar conjunctiva, the  presence of  a  nodular formation  (conflicts), slight edema of  the corneal epithelium) and a  history of  concomitant diseases: arterial hypertension, diabetes, coronary heart disease, atherosclerosis. Group 2 patients (n = 41) with no history of concomitant diseases and similar post-COVID changes in  the conjunctiva. The control group consisted of  healthy volunteers without a  history of coronavirus infection (n = 30). All subjects underwent laser Doppler flowmetry of the bulbar conjunctiva 3, 6, 12 months after the coronavirus infection.

Results and discussion. In comparison with the control group of persons after 3 months, microcirculatory disorders were detected in both groups (group 1 – subcompensated, group 2 – decompensated). In group 1, after 6 months and 12 months, violations persisted in  the subcompensation stage, which were accompanied by an increase in  the intensity of  the functioning of  the regulatory systems of the microcirculation: the M index corresponded to normal values, and the values of σ and Kv were above the norm. After 6 months in group 2, compensation of microcirculatory disorders was noted (indicators M, σ, Kv were normal), which persisted even by 12 months of observation.

Conclusion. The data obtained indicate that in patients with concomitant endothelial dysfunction, the processes of restoration of the microvasculature are slowed down.
A personalised approach to the choice of oral anticoagulants in elderly and senile patients with atrial fibrillation
Authors: Shikh E. V. , Shindryaeva N. N. , Rebrova E. V. , Lapidus N. I. , Zhukova O. V. , Stuk I. V. , Koroleva I. G.
Published: August 2022

Introduction. In recent years, data have been accumulated regarding possible associations between cognitive impairment and atrial fibrillation. The results of retrospective and prospective studies confirm that anticoagulant therapy in patients with AF can reduce the risk of cognitive impairment and dementia.

Objective. To study the individual characteristics of elderly and senile patients with atrial fibrillation, influencing the choice of anticoagulant therapy, with a view to its subsequent optimization.

Materials and methods. The study included 159 patients with atrial fibrillation of non-valvular genesis aged over 60 years. 4 groups of patients were formed. The largest number of patients received rivaroxaban and warfarin (36.4% and 34.6%, respectively). 26 (16.3%) patients were treated with dabigatran, 20 (12.6%) patients with apixaban. The risk of thromboembolic complications was assessed on the CHA2DS2-VASc scale. The HAS-BLED scale was used to assess the risk of bleeding. A pharmacogenetic study (carriage of polymorphic alleles of the CYP2C9 and VCORC1 genes) was conducted in 138 patients. Cognitive impairment was assessed by a Mini-Cog test and a battery of frontal tests.

Results. Taking oral anticoagulants reduces the risk of stroke and dementia in patients; the presence of cognitive impairment, in  turn, significantly reduces the patient’s adherence to therapy and reduces the effectiveness of therapy. Patients’ adherence to therapy was significantly lower by 10–20% in patients with cognitive impairment according to the Mini-Cog test and a battery of frontal tests. In the absence of pronounced cognitive impairment (higher adherence to treatment) and availability and willingness to control INR, warfarin remains the drug of choice in patients with renal insufficiency.

Conclusions. A number of problems with the use of oral anticoagulants in elderly patients with atrial fibrillation have been identified. The ease of use of new oral anticoagulants, the absence of the need to select doses and monitor therapy is an important factor when choosing a drug.