bluuebunny/crossref_metadata_2025 huggingface dataset:
A Companion Diagnostic With Significant Clinical Impact in Treatment of Breast and Gastric Cancer
Authors: Jørgensen Jan Trøst , Winther Henrik , Askaa Jon , Andresen Lena , Olsen Dana , Mollerup Jens
Published: July 2021

The development of trastuzumab (Herceptin®) was one of the most significant cancer drug development projects of the 20th century. Not only was it a scientific and medical achievement but it also paved the way for the drug-diagnostic codevelopment model, where a predictive biomarker assay is developed in parallel to the drug. One of the challenges in the development of trastuzumab was to select the right patient population likely to respond and here, it was critical to have access to an accurate, robust and reliable assay for detection of HER2 overexpression in tumors. In the clinical development of trastuzumab, a clinical trial assay (CTA), developed by Genentech, was used for selection of HER2 positive patients. However, during the phase III trial with trastuzumab, a new optimized IHC assay, HercepTest™ was designed and developed by Dako. In the final stage of its development, a comparative study with the CTA was conducted in order to show concordance between the two assays. In September 1998, the Food and Drug Administration (FDA) simultaneously granted approval to trastuzumab and HercepTest™. The assay has been used for patient selection in a number of significant breast cancer clinical trials such as the HERA, CLEOPATRA, EMILIA and more. In these trials, HercepTest™ demonstrated its clinical utility in the neoadjuvant, adjuvant, and metastatic setting as well as in relation to different types of HER2 targeted therapies. Likewise, the assay was used for selection of HER2 positive gastric cancer patients in the important ToGA trail. HercepTest™ was the first companion diagnostic ever approved by the FDA, and more than 20 years of use has documented its clinical impact.
Two Novel HSD17B4 Heterozygous Mutations in Association With D-Bifunctional Protein Deficiency: A Case Report and Literature Review
Authors: Chen Si , Du Linrun , Lei Yihui , Lin Yuanyuan , Chen Shangqin , Liu Yanli
Published: July 2021

Background: D-Bifunctional protein deficiency (D-BPD) is an autosomal recessive disorder caused by peroxisomal β-oxidation defects. According to the different activities of 2-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase protein units, D-bifunctional protein defects can be divided into four types. The typical symptoms include hypotonia and seizures. The gene that encodes D-BP was HSD17B4, which is located in chromosome 5q23.1.

Case Presentation: We report the first case of D-BPD in a Chinese patient with neonatal onset. Cosmetic malformations, severe hypotonia and seizures are prominent. The blood bile acid profile showed increased taurocholic acid, glycocholic acid, and taurochenodeoxycholic acid. Very-long-chain fatty acids (VLCFAs) revealed significant increases in hexacosanoic acid (C26:0), tetracosanoic acid/docosanoic acid (C24:0/C22:0), and hexacosanoic acid/docosanoic acid (C26:0/C22:0). Cranial MRI revealed bilateral hemispheric and callosal dysplasia, with schizencephaly in the right hemisphere. EEG showed loss of sleep–wake cycle and epileptiform discharge. Other examinations include abnormal brainstem auditory evoked potentials (BAEPs) and temporal pigmented spots on the optic disc in the right eye. After analysis by whole-exome sequencing, heterozygous c.972+1G>T in the paternal allele and c.727T>A (p.W243R) in the maternal allele were discovered. He was treated with respiratory support, formula nasogastric feeding, and antiepileptic therapy during hospitalization and died at home due to food refusal and respiratory failure at the age of 5 months.

Conclusions: Whole-exome sequencing should be performed in time to confirm the diagnosis when the newborn presents hypotonia, seizures, and associated cosmetic malformations. There is still a lack of effective radical treatment. Supportive care is the main treatment, aiming at controlling symptoms of central nervous system like seizures and improving nutrition and growth. The disease has a poor outcome, and infants often die of respiratory failure within 2 years of age. In addition, heterozygous deletion variant c.972+1G>T and missense mutations c.727T>A (p.W243R) are newly discovered pathogenic variants that deserve further study.
Prediction of Rivaroxaban-Rifampin Interaction After Major Orthopedic Surgery: Physiologically Based Pharmacokinetic Modeling and Simulation
Authors: Xu Rui-juan , Ling Tao , Tang Hong , Ge Wei-hong , Jiang Qing
Published: July 2021

Rivaroxaban is commonly used for the prophylaxis of venous thromboembolism (VTE) for patients undergoing major orthopedic surgery. Rivaroxaban is primarily eliminated by hepatic CYP450 metabolism and renal excretion. Rifampin is a commonly used antibiotic for prosthetic joint infections (PJI) and a potent inducer of CYP450 enzymes. Clinical data about drug-drug interactions of rivaroxaban and rifampin are limited. The present study is to describe DDI of rivaroxaban and rifampin in several prosthetic joint infections patients undergoing major orthopedic surgery. We retrospectively identified six patients concomitantly administered with rivaroxaban and rifampin between 2019 and 2020. Plasma samples of these patients with accurate sampling time were chosen from the biobank and plasma levels of rivaroxaban were measured at each time point. A physiologically based pharmacokinetic model for the rivaroxaban-rifampin interaction was developed to predict the optimal dosing regimen of rivaroxaban in the case of co-medication with rifampin. The model was validated by the observed plasma concentration of rivaroxaban from the above patients. From this model, it could be simulated that when rifampin starts or stops, gradually changing rivaroxaban dose during the first few days would elevate the efficacy and safety of rivaroxaban.
Constructing Adult Zebrafish Einthoven’s Triangle to Define Electrical Heart Axes
Authors: Zhao Yali , Chen Connie , Yun Morgan , Issa Thomas , Lin Andrew , Nguyen Thao P.
Published: July 2021

Zebrafish is a popular high-throughput vertebrate model to study human cardiac electrophysiology, arrhythmias, and myopathies. One reason for this popularity is the purported striking similarities between zebrafish and human electrocardiograms (ECGs). However, zebrafish electrical heart axes were unknown. It is impossible to define heart axis based on single-lead ECG because determination of an electrical heart axis in the frontal plane requires the use of the hexaxial reference system (or Cabrera system) derived from Einthoven’s triangle. Construction of Einthoven’s triangle requires simultaneous ECG recording from at least two Einthoven bipolar leads. Therefore, we systematically constructed the first zebrafish Einthoven’s triangle by simultaneous bipolar dual-lead ECG recording to determine for the first time the three frontal electrical heart axes using the Cabrera system. Comparing zebrafish with human Einthoven’s triangle reveals that their normal frontal electrical axes were reflections of each other across 0° in the Cabrera system. The responsible mechanisms involve zebrafish vs. human cardiac activation propagating in the same direction along the heart horizontal axis but in opposite directions along the heart longitudinal axis. The same observations are true for zebrafish vs. human cardiac repolarization. This study marks a technical breakthrough in the first bipolar dual-lead ECG recording in live adult zebrafish to construct for the first time zebrafish Einthoven’s triangle. This first systematic analysis of the actual differences and similarities between normal adult zebrafish and human Einthoven’s triangles unmasked differences and similarities in the underlying cardiac axis mechanisms. Insights of the live adult zebrafish main heart axis and its three frontal electrical heart axes provide critical contextual framework to interpret the clinical relevance of the adult zebrafish heart as model for human cardiac electrophysiology.
EARLY STARVATION 1 Is a Functionally Conserved Protein Promoting Gravitropic Responses in Plants by Forming Starch Granules
Authors: Song Kijong , Lee Dae-Woo , Kim Jeongheon , Kim Jaewook , Guim Hwanuk , Kim Keunhwa , Jeon Jong-Seong , Choi Giltsu
Published: July 2021

Starch granules in the endodermis of plant hypocotyls act as statoliths that promote hypocotyl negative gravitropism—the directional growth of hypocotyls against gravity—in the dark. To identify the molecular components that regulate hypocotyl negative gravitropism, we performed a mutagenesis screen and isolated reduced gravitropic 1 (rgv1) mutants that lack starch granules in their hypocotyl endodermis and show reduced hypocotyl negative gravitropism in the dark. Using whole genome sequencing, we identified three different rgv1 mutants that are allelic to the previously reported early starvation 1 mutant, which is rapidly depleted of starch just before the dawn. ESV1 orthologs are present in starch-producing green organisms, suggesting ESV1 is a functionally conserved protein necessary for the formation of starch granules. Consistent with this, we found that liverwort and rice ESV1 can complement the Arabidopsis ESV1 mutant phenotype for both starch granules and hypocotyl negative gravitropism. To further investigate the function of ESV1 in other plants, we isolated rice ESV1 mutants and found that they show reduced levels of starch in their leaves and loosely packed starch granules in their grains. Both Arabidopsis and rice ESV1 mutants also lack starch granules in root columella and show reduced root gravitropism. Together, these results indicate ESV1 is a functionally conserved protein that promotes gravitropic responses in plants via its role in starch granule formation.
Abscisic Acid Mediates Drought-Enhanced Rhizosheath Formation in Tomato
Authors: Karanja Joseph K. , Aslam Mehtab Muhammad , Qian Zhang , Yankey Richard , Dodd Ian C. , Weifeng Xu
Published: July 2021

The rhizosheath, commonly defined as soil adhering to the root surface, may confer drought tolerance in various crop species by enhancing access to water and nutrients under drying stress conditions. Since the role of phytohormones in establishing this trait remains largely unexplored, we investigated the role of ABA in rhizosheath formation of wild-type (WT) and ABA-deficient (notabilis, not) tomatoes. Both genotypes had similar rhizosheath weight, root length, and root ABA concentration in well-watered soil. Drying stress treatment decreased root length similarly in both genotypes, but substantially increased root ABA concentration and rhizosheath weight of WT plants, indicating an important role for ABA in rhizosheath formation. Neither genotype nor drying stress treatment affected root hair length, but drying stress treatment decreased root hair density ofnot. Under drying stress conditions, root hair length was positively correlated with rhizosheath weight in both genotypes, while root hair density was positively correlated with rhizosheath weight in well-waterednotplants. Root transcriptome analysis revealed that drought stress increased the expression of ABA-responsive transcription factors, such as AP2-like ER TF, alongside other drought-regulatory genes associated with ABA (ABA 8′-hydroxylase and protein phosphatase 2C). Thus, root ABA status modulated the expression of specific gene expression pathways. Taken together, drought-induced rhizosheath enhancement was ABA-dependent, but independent of root hair length.
Nitric Oxide Functions as a Downstream Signal for Melatonin-Induced Cold Tolerance in Cucumber Seedlings
Authors: Feng Yiqing , Fu Xin , Han Lujie , Xu Chenxiao , Liu Chaoyue , Bi Huangai , Ai Xizhen
Published: July 2021

Melatonin (MT) and nitric oxide (NO) are two multifunctional signaling molecules that are involved in the response of plants to abiotic stresses. However, how MT and NO synergize in response to cold stress affecting plants is still not clear. In this study, we found that endogenous MT accumulation under cold stress was positively correlated with cold tolerance in different varieties of cucumber seedlings. The data presented here also provide evidence that endogenous NO is involved in the response to cold stress. About 100 μM MT significantly increased the nitrate reductase (NR) activity,NR-relative messenger RNA (mRNA) expression, and endogenous NO accumulation in cucumber seedlings. However, 75 μM sodium nitroprusside (SNP, a NO donor) showed no significant effect on the relative mRNA expression of tryptophan decarboxylase (TDC), tryptamine-5-hydroxylase (T5H), serotonin-N-acetyltransferase (SNAT), or acetylserotonin O-methyltransferase (ASMT), the key genes for MT synthesis and endogenous MT levels. Compared with H2O treatment, both MT and SNP decreased electrolyte leakage (EL), malondialdehyde (MDA), and reactive oxygen species (ROS) accumulation by activating the antioxidant system and consequently mitigated cold damage in cucumber seedlings. MT and SNP also enhanced photosynthetic carbon assimilation, which was mainly attributed to an increase in the activity and mRNA expression of the key enzymes in the Calvin–Benson cycle. Simultaneously, MT- and SNP-induced photoprotection for both photosystem II (PSII) and photosystem I (PSI) in cucumber seedlings, by stimulating the PsbA (D1) protein repair pathway and ferredoxin-mediated NADP+photoreduction, respectively. Moreover, exogenous MT and SNP markedly upregulated the expression of chilling response genes, such as inducer ofCBFexpression (ICE1), C-repeat-binding factor (CBF1), and cold-responsive (COR47). MT-induced cold tolerance was suppressed by 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO, a specific scavenger of NO). However, p-chlorophenylalanine (p-CPA, a MT synthesis inhibitor) did not affect NO-induced cold tolerance. Thus, novel results suggest that NO acts as a downstream signal in the MT-induced plant tolerance to cold stress.
Application of Near-Infrared Spectroscopy for Evidence-Based Psychotherapy
Authors: Ozawa Sachiyo
Published: July 2021

This perspective article discusses the importance of evidence-based psychotherapy and highlights the usefulness of near-infrared spectroscopy (NIRS) in assessing the effects of psychotherapeutic interventions as a future direction of clinical psychology. NIRS is a safe and non-invasive neuroimaging technique that can be implemented in a clinical setting to measure brain activity via a simple procedure. This article discusses the possible benefits and challenges of applying NIRS for this purpose, and the available methodology based on previous studies that used NIRS to evaluate psychotherapeutic effects. Furthermore, this perspective article suggests alternative methodologies that may be useful, namely, the single- and multi-session evaluations using immediate pre- and post-intervention measurements. These methods can be used to evaluate state changes in brain activity, which can be derived from a single session of psychotherapeutic interventions. This article provides a conceptual schema important in actualizing NIRS application for evidence-base psychotherapy.
Assessment Methods for Service-Learning Projects in Engineering in Higher Education: A Systematic Review
Authors: Queiruga-Dios Marián , Santos Sánchez María Jesús , Queiruga-Dios Miguel Ángel , Acosta Castellanos Pedro Mauricio , Queiruga-Dios Araceli
Published: July 2021

Service-learning (SL) helps engineering students to be involved in community activities and to be motivated by their studies. Although several reviews and research studies have been published about SL, it is not widespread in sciences and engineering at the university level. The purpose of this research is to analyze the different community services or projects where SL is implemented by engineering students and faculty and to identify the procedures that were usually implemented to assess SL-based courses and activities. Assessment could be considered as the evaluation of a specific module and the engineering competencies, the evaluation of the effectiveness of the SL program, the assessment of the participation of the student in those programs, and the assessment of whether students have achieved certain outcomes or gained specific skills. We conducted a systematic review with a search in three scientific databases: Scopus, Science Direct, and ERIC educational database to analyze the assessment methods and what that assessment covers. From 14,107 publications related to SL, 120 documents were analyzed to inform the conclusions of this study. We found that SL is widely used in several universities as experiential education, and it is considered an academic activity. The most widely used assessment technique is a survey to evaluate the engagement and attitudes of students and, to a lesser extent, teamwork presentations.
Investigating Emotion Perception via the Two-Dimensional Affect and Feeling Space: An Example of a Cross-Cultural Study Among Chinese and Non-Chinese Participants
Authors: Lorette Pernelle
Published: July 2021

The categorical approach to cross-cultural emotion perception research has mainly relied on constrained experimental tasks, which have arguably biased previous findings and attenuated cross-cultural differences. On the other hand, in the constructionist approach, conclusions on the universal nature of valence and arousal have mainly been indirectly drawn based on participants' word-matching or free-sorting behaviors, but studies based on participants' continuous valence and arousal ratings are very scarce. When it comes to self-reports of specific emotion perception, constructionists tend to rely on free labeling, which has its own limitations. In an attempt to move beyond the limitations of previous methods, a new instrument called the Two-Dimensional Affect and Feeling Space (2DAFS) has been developed. The 2DAFS is a useful, innovative, and user-friendly instrument that can easily be integrated in online surveys and allows for the collection of both continuous valence and arousal ratings and categorical emotion perception data in a quick and flexible way. In order to illustrate the usefulness of this tool, a cross-cultural emotion perception study based on the 2DAFS is reported. The results indicate the cross-cultural variation in valence and arousal perception, suggesting that the minimal universality hypothesis might need to be more nuanced.
The Role of Coping Behavior in Healthcare Workers' Distress and Somatization During the COVID-19 Pandemic
Authors: Franck Erik , Haegdorens Filip , Goossens Eva , van Gils Yannic , Portzky Michael , Somville Francis , Abuawad Majed , Slootmans Stijn , Van Bogaert Peter
Published: July 2021

Background: Constantly searching for a balance between work demands and their own physical and psychological health has challenged medical and nursing staff during the immediate wake of this COVID-19 viral epidemic leading to acute stress reactions and psychosomatic symptoms. Coping behavior might be a buffer for work-related stress in relation to mental well-being. The present study aims to evaluate the role of positive and negative stress-reducing activities on healthcare workers' mental and physical well-being.

Methods: This was a cross-sectional study using an online survey that was sent out using our network of healthcare workers at the University of Antwerp and through social media. Socio-demographic data, coping behavior with the Palliative Pallet Scale (P3), and distress and somatization using the Four-dimensional symptom checklist were collected. Surveys were completed by 1,376 participants.

Results: The results clearly showed that positive stress-reducing activities are related to fewer symptoms of distress and somatization. Providing direct care to COVID-19 patients was associated with a higher decrease of applying positive stress-reducing activities during the peak of the pandemic compared to the ideal situation. Finally, fewer symptoms of distress and somatization were associated with the following activities: reading, mind sports games, keeping a hobby collection, studying; engaging in sexual activities with your partner; cleaning the house, tidying up, working in the garden, doing household chores; exercising alone; walking, or taking a trip together with someone; exercise together with someone; watching TV, listening/playing (to) music/, playing computer games; playing a card game or other board game; and preparing something extra tasteful outside regular meals.

Conclusion: Our study demonstrated an association between concrete coping behaviors and distress and somatization in healthcare workers during the first peak of the COVID-19 pandemic. The results provide relevant and additional insights to develop and investigate interventions among others in personal leadership and resilience.
Female Labor Force Status and Couple's Marital Satisfaction: A Chinese Analysis
Authors: Yu Xiao , Liu Shu
Published: July 2021

While China has decreasing female labor participation and increasing marital instability, compared to the rest of the world, its female labor participation rate is higher on average. The effect of female labor force status on couples' marital satisfaction, as one of the main factors for evaluating marital quality, has been separately discussed, including extensive margins considering whether women are in the labor market and intensive margins on women working hours per week. This study analyzed data from the 2014 China Family Panel Studies (CFPS) using a binary logit model and a stability test. Results showed that the work hours, rather than the occupational status, of women affect marital satisfaction. In addition, regardless of the gender role attitudes held by the couple, marital satisfaction increases when women are in the labor market. This study has retroactively reviewed the effects of women working outside the home on marital quality. The dual roles of Chinese women, as both employee and homemaker, have been socially accepted. However, the requirements of maintaining multiple roles often contradict and present conflicts among the roles, time, and pressure, in the long run, giving rise to marital dissatisfaction.
Familiarity and Novelty in Aesthetic Preference: The Effects of the Properties of the Artwork and the Beholder
Authors: Song Jiwon , Kwak Yuna , Kim Chai-Youn
Published: July 2021

Familiarity and novelty are fundamental yet competing factors influencing aesthetic preference. However, whether people prefer familiar paintings or novel paintings has not been clear. Using both behavioral and eye-tracking measures, the present study aimed to investigate whether the effect of familiarity-novelty on aesthetic preference is independent or dependent on artwork properties (painting content, visual complexity) and viewer characteristics (experience in art). Participants were presented with two images of paintings, one of which was repeatedly presented but was always paired with a new painting in a randomized lateral arrangement. They were asked to indicate which of the two images they preferred with the degree of their preference. Behavioral results demonstrated an interactive influence of painting content and complexity on familiarity-novelty preference, especially alongside the distinction between representational and abstract paintings. Also, the familiarity-novelty preference was modulated by the degree of art experience, for abstract paintings in particular. Gaze results showed the differential effects of painting content, complexity, and art experience echoing the behavioral results. Taken together, the convergent results derived from behavioral and eye-tracking measures imply that novelty is an important feature of aesthetic appreciation, but its influence is modulated by properties of both the artwork and the beholder.
Changes in Violence and Clinical Distress Among Men in Individual Psychotherapy for Violence Against Their Female Partner: An Explorative Study
Authors: Askeland Ingunn Rangul , Birkeland Marianne Skogbrott , Lømo Bente , Tjersland Odd Arne
Published: July 2021

Most interventions for men who have acted violently toward their partner have been conducted as group interventions within a criminal justice context. Therefore, few studies have examined individual psychotherapy and how such interventions may reduce partner violence. In this study, we aimed to describe changes in violence, and changes in clinical distress in men undergoing individual psychotherapy targeting their use of partner violence, at a clinic organized within a psychosocial health care context. This is a naturalistic prospective study of men voluntarily receiving individual psychotherapy for their use of violence against their female partner. Participants were 84 male clients, and data on their use of physical violence, physical controlling violence, property violence and psychological violence were collected pretreatment, posttreatment and at follow-up 1.5 years after treatment from both the men, and their partners (n = 58). The percentage of use of all types of violence during a typical month the last year decreased from pretreatment to follow-up, according to both the men, and their partners. Over the course of treatment, use of all types of self-reported violence during the last month was reduced, however, this was only partially confirmed by their partners. Number of sessions was associated with a lower risk of having used physical and physically controlling violence 1.5 years after treatment. Alcohol abuse or dependency, or qualifying for one or more psychiatric diagnoses, were not associated with levels or change in use of violence. On average, the men's clinical distress declined over the course of psychotherapy. The findings suggest that individual psychotherapy may be a promising and worthwhile intervention for intimate partner violence. Studies with more elaborate designs are needed to identify the core mechanisms of psychotherapy for violence, and to corroborate these results with higher levels of evidence.
Virtual Reality-Assisted Cognitive Behavioral Therapy for Anxiety Disorders: A Systematic Review and Meta-Analysis
Authors: Wu Jinlong , Sun Yi , Zhang Gongwei , Zhou Zhenhui , Ren Zhanbing
Published: July 2021

Objective: We aim to explore the effectiveness of virtual reality-assisted cognitive behavioral therapy (VRCBT) in the treatment of anxiety and depression in patients with anxiety disorders. We further compare the therapeutic effect of VRCBT with that of standard cognitive behavioral therapy (CBT), as well as investigate the long-term efficacy of VRCBT.

Methods: As of March 3, 2020, a total of four databases (Web of Science, PubMed, PsycINFO, and Scopus) were retrieved, and two researchers independently conducted literature retrieval and research selection and performed data extraction. Methodological quality assessment was performed using the Cochrane risk of bias tool and Grading of Recommendation, Assessment, Development, and Evaluation tool (GRADE).

Results: A total of 11 studies were included (n = 626; range, 25.3–43.8), and six randomized controlled trials were quantitatively analyzed. The main outcome was anxiety and depression, and the secondary outcome was the withdrawal rate and long-term effects. Meta-analysis showed that the therapeutic effect of VRCBT on anxiety was better than that of the waiting list group (WLG) (SMD = −0.92; 95% CI: −1.34, −0.50; p = 0.005, I2 = 66%, n = 276), while the therapeutic effect of VRCBT on anxiety was similar to that of standard CBT treatment (SMD = −0.26; 95% CI: −0.50, −0.01; p = 0.77, I2 = 0%, n = 150). We further found that the therapeutic effect of VRCBT on depression was better than that of the WLG (SMD = −1.29; 95% CI: −2.26, −0.32; p = 0.09, I2 = 58%, n = 74), while the effect of VRCBT was similar to that of standard CBT (SMD = −0.30; 95% CI: −0.67, −0.07; p = 0.39, I2 = 1%, n = 116). Of the five studies that reported withdrawal rates of patients during the VRCBT and CBT treatment process, the withdrawal rates of the VRCBT group and CBT group did not reach statistical significance (OR = 0.70, 1.48, p > 0.05); only two studies reported the long-term effectiveness of VRCBT in anxiety and depression on patients with anxiety disorders.

Conclusion: VRCBT treatment has a specific positive effect on patients with anxiety disorders (anxiety and depression). Compared with standard CBT, similar therapeutic effects can be achieved in the treatment of anxiety disorders. However, limited randomized controlled trials were included, requiring that these results be treated with caution.
Effects of Chronic Alcohol Use Disorder on the Visual Tilt Illusion
Authors: Gao Guoqing , Yin Liangshuang , Cheng Jun , Tao Rui , Liu Yu , Pang Liangjun , Wang Zhengchun
Published: July 2021

Rationale: Among the serious consequences of alcohol use disorder (AUD) is the reduced ability to process visual information. It is also generally agreed that AUD tends to occur with disturbed excitation–inhibition (EI) balance in the central nervous system. Thus, a specific visual behavioral probe could directly qualify the EI dysfunction in patients with AUD. The tilt illusion (TI) is a paradigmatic example of contextual influences on perception of central target. The phenomenon shows a characteristic dependence on the angle between the inducing surround stimulus and the central target test. For small angles, there is a repulsion effect; for larger angles, there is a smaller attraction effect. The center-surround inhibition in tilt repulsion is considered to come from spatial orientational interactions between orientation-tuned neurons in the primary visual cortex (V1), and tilt attraction is from higher-level effects of orientation processing in the visual information processing.

Objectives: The present study focuses on visual spatial information processing and explores whether chronic AUD patients in abstinence period exhibited abnormal TI compared with healthy controls.

Methods: The participants are 30 male volunteers (20–46 years old) divided into two groups: the study group consists of 15 clinically diagnosed AUD patients undergoing abstinence from alcohol, and the control group consists of 15 healthy volunteers. The TI consists of a center target surround with an annulus (both target and annulus are sinusoidal grating with spatial frequency = 2 cycles per degree). The visual angle between center and surround is a variable restricted to 0°, ±15°, ±30°, or ±75°. For measuring the TI, participants have to report whether the center target grating orientation tilted clockwise or counterclockwise from the internal vertical orientation by pressing corresponding keys on the computer keyboard. No feedback is provided regarding response correctness.

Results: The results reveal significantly weaker tilt repulsion effect under surround orientation ±15° (p < 0.05) and higher lapse rate (attention limitation index) under all tested surround orientations (all ps < 0.05) in patients with chronic AUD compared with health controls.

Conclusions: These results provide psychophysical evidence that visual perception of center-contextual stimuli is different between AUD and healthy control groups.
Impulsivity as a Risk Factor for Suicide in Bipolar Disorder
Authors: Zakowicz Przemysław , Skibińska Maria , Wasicka-Przewoźna Karolina , Skulimowski Bartosz , Waśniewski Filip , Chorzepa Aneta , Różański Maciej , Twarowska-Hauser Joanna , Pawlak Joanna
Published: July 2021

The accurate assessment of suicide risk in psychiatric, especially affective disorder diagnosed patients, remains a crucial clinical need. In this study, we applied temperament and character inventory (TCI), Barratt impulsiveness scale 11 (BIS-11), PEBL simple reaction time (SRT) test, continuous performance task (CPT), and Iowa gambling task (IGT) to seek for variables linked with attempted suicide in bipolar affective disorder group (n = 60; attempters n = 17). The main findings were: strong correlations between self-report tool scores and objective parameters in CPT; the difference between attempters and non-attempters was found in the number of correctly responded trials in IGT; only one parameter differed between attempters and non-attempters in BPI diagnosis; and no significant differences between suicide attempters and non-attempters in TCI, BIS-11, and SRT were found. These justify the conclusion that impulsivity itself is not a strong predictor, and used as a single variable might not be sufficient to indicate the high suicide risk group among bipolar patients.
National Biosafety Management System: A Combined Framework Approach Based on 15 Key Elements
Authors: Orelle Arnaud , Nikiema Abdoulaye , Zakaryan Arsen , Albetkova Adilya A. , Rayfield Mark A. , Peruski Leonard F. , Pierson Antoine , Kachuwaire Obert
Published: July 2021

The pervasive nature of infections causing major outbreaks have elevated biosafety and biosecurity as a fundamental component for resilient national laboratory systems. In response to international health security demands, the Global Health Security Agenda emphasizes biosafety as one of the prerequisites to respond effectively to infectious disease threats. However, biosafety management systems (BMS) in low-medium income countries (LMIC) remain weak due to fragmented implementation strategies. In addition, inefficiencies in implementation have been due to limited resources, inadequate technical expertise, high equipment costs, and insufficient political will. Here we propose an approach to developing a strong, self-sustaining BMS based on extensive experience in LMICs. A conceptual framework incorporating 15 key components to guide implementers, national laboratory leaders, global health security experts in building a BMS is presented. This conceptual framework provides a holistic and logical approach to the development of a BMS with all critical elements. It includes a flexible planning matrix with timelines easily adaptable to different country contexts as examples, as well as resources that are critical for developing sustainable technical expertise.
Nurturing Spiritual Resilience to Promote Post-disaster Community Recovery: The 2016 Alberta Wildfire in Canada
Authors: Lalani Nasreen , Drolet Julie L. , McDonald-Harker Caroline , Brown Matthew R. G. , Brett-MacLean Pamela , Agyapong Vincent I.O. , Greenshaw Andrew J. , Silverstone Peter H.
Published: July 2021

The 2016 Alberta wildfire, the largest insured natural disaster in Canada, led to a mass evacuation of residents of Fort McMurray, a small city in northern Alberta. The wildfire resulted in significant damages to housing and community infrastructure. The entire community was displaced for several weeks. Post-disaster, community members experienced individual and collective trauma, and other negative mental health impacts in response to the significant losses and grief they endured. Spirituality has been found to be a major protective factor in facilitating resiliency and recovery following the experience of disaster. Nonetheless, little focus has been directed toward how spirituality can strengthen and empower community capacity and growth during post-disaster recovery. Our study explored various meanings and concerns, along with tools and strategies that helped to nurture spiritual resilience and well-being among residents of Fort McMurray following the Alberta wildfire. Data were collected through interviews and focus group discussions with community influencers working to support long-term recovery efforts in the city. Participants identified a number of spiritual resources such as a strong sense of belonging, a shared positive outlook, faith and hope, compassion, and sense of gratitude, which contributed to increased resilience and positive health and well-being and helped them to support families and communities in the post disaster recovery period. Our findings indicate that spiritual values and beliefs can play a significant role in building resilience and promoting individual and communal healing and recovery post-disaster. These findings have important implications for post-disaster recovery strategies, as they highlight the need to ensure supports for interventions and initiatives that strengthen a collective sense of identity and social cohesion, informed by communal norms and beliefs, including programs and resources which support opportunities for reflexivity to foster shared healing and ongoing recovery processes.
The Influence of Mental Health Literacy, Migration, and Education on the Duration of Untreated Psychosis
Authors: Takizawa Naomi , Melle Ingrid , Barrett Elizabeth Ann , Nerhus Mari , Ottesen Akiah A.
Published: July 2021

Background: Duration of untreated psychosis (DUP) is associated with outcome in psychotic disorders and influenced by contextual factors such as immigration. Here we aimed to investigate the effect of mental health literacy (MHL) on duration of untreated psychosis considering the influence of migration and education.

Methods: A total of 269 participants who received their first adequate medical treatment for a psychotic disorder within the current or past year were included to the Thematically Organized Psychosis study in Oslo, Norway. Sociodemographic and clinical information was collected through systematic interviews. MHL was measured as “recognition of psychotic symptoms” and assessed by “The Attitudes and Beliefs about Mental Health Problems” schizophrenia version. Influence of education, migration and MHL on DUP was analyzed with hierarchical block-wise multiple regression analysis.

Results: Recognition of psychotic symptoms explained a small but unique variance (2.3%) in DUP after the effects of other important predictors were controlled for. Longer DUP was also associated with less education, lower premorbid social, and academic functioning, a diagnosis within schizophrenia spectrum disorder, and earlier age of onset. The model explained 26% of variance in DUP. Migration after the age of six and length of education were associated with MHL but did not have a significant interaction with MHL in predicting DUP.

Conclusions: MHL, measured as recognition of psychotic symptoms, has a small but significant independent effect on DUP. The effect of MHL was larger than years of education and migration history, and did not interact with either, in predicting DUP. This suggests that MHL is an independent factor in prevention strategies for early psychosis.
Metformin Enhances B Cell Function and Antibody Responses of Elderly Individuals With Type-2 Diabetes Mellitus
Authors: Frasca Daniela , Diaz Alain , Romero Maria , Blomberg Bonnie B.
Published: July 2021

Our previous work has shown that young and elderly patients with Type-2 Diabetes Mellitus (T2DM) treated with Metformin have optimal B cell function and serum antibodies specific for the seasonal influenza vaccine. In this paper, we have evaluated B cell function and the metabolic requirements of B cell antibody responses in elderly T2DM patients (ET2DM) taking or not Metformin, and compared to those of healthy elderly (EH) and healthy young (YH) individuals. Results show that Metformin significantly increasesin vivoB cell function, measured by influenza vaccine-specific serum antibodies, in ET2DMpatients to the levels observed in EHand more importantly in YHindividuals. Metformin also decreases the frequencies of pro-inflammatory B cell subsets, as well as intrinsic inflammation and metabolic requirements of peripheral B cells from ET2DM. This hyper-metabolic phenotype of B cells from ET2DMis needed to support intrinsic inflammation, measured by the expression of transcripts for markers of the senescence-associated secretory phenotype (SASP), and the secretion of autoimmune antibodies. Importantly, B cell function in ET2DMpatients taking Metformin is not only increased as compared to that in ET2DMpatients not taking Metformin, but is comparable to B cell function measured in YHindividuals. These results altogether strongly support the anti-aging effects of Metformin on humoral immunity.
The Multi-hub Academic Conference: Global, Inclusive, Culturally Diverse, Creative, Sustainable
Authors: Parncutt Richard , Lindborg PerMagnus , Meyer-Kahlen Nils , Timmers Renee
Published: July 2021

New conference formats are emerging in response to COVID-19 and climate change. Virtual conferences are sustainable and inclusive regardless of participant mobility (financial means, caring commitments, disability), but lack face-to-face contact. Hybrid conferences (physical meetings with additional virtual presentations) tend to discriminate against non-fliers and encourage unsustainable flying. Multi-hub conferences mix real and virtual interactions during talks and social breaks and are distributed across nominally equal hubs. We propose a global multi-hub solution in which all hubs interact daily in real time with all other hubs in parallel sessions by internet videoconferencing. Conference sessions are confined to three equally-spaced 4-h UTC timeslots. Local programs comprise morning and afternoon/evening sessions (recordings from night sessions can be watched later). Three reference hubs are located exactly 8 h apart; additional hubs are within 2 h and their programs are aligned with the closest reference hub. The conference experience at each hub depends on the number of local participants and the time difference to the nearest reference. Participants are motivated to travel to the nearest hub. Mobility-based discrimination is minimized. Lower costs facilitate diversity, equity, and inclusion. Academic quality, creativity, enjoyment, and low-carbon sustainability are simultaneously promoted.
Local Culture and Urban Retrofit: Reflections on Policy and Preferences for Wall and Roof Materials
Authors: Cravioto Jordi , Mosqueda Augusto
Published: July 2021

Retrofitting strategies aim to reduce environmental footprints promoting the development or upgrade of existing infrastructure. One crucial aspect of successful retrofitting strategies is local culture, which can harmonise or come into conflict with retrofitting initiatives. However, investigations on the influence of local practises, particularly in the global south, are limited and such influence deserves more attention. This article explores the connexion between local culture and retrofitting strategies, focusing on wall and roof material selection in the Metropolitan Valley of Oaxaca in Mexico (ZMVO). We begin with a brief review of the retrofitting initiatives at related governmental levels. Then, through a survey, we analyse the choices and reasons for selecting specific materials for walls and roofs in the ZMVO. We discuss to what extent cultural practises and preferences have been considered or left behind in the strategies and ensuing challenges. The findings confirm important premises. First, tradition and community support were not relevant factors in wall or roof material selection. Material reuse, energy efficiency, and sustainability-related reasons were also not essential to the preferences. Instead, protection (against rain, earthquakes, theft and accidents), hygiene, and aesthetics had a consistently higher priority. We also found that poverty or lack of other options intersects with the use of precarious materials, creating constrained choices. However, the most crucial finding was that choosing less environmentally or culturally compatible materials was strongly connected with deprivation, having important implications in the selection of materials and retrofitting strategies. The current retrofitting initiatives call for sustainability and efficiency, but the local practises render these efforts insufficient and incoherent. Poverty and informal housing are the main emphases of the local policy. However, the policy focuses on new infrastructure and much less on the existing housing, causing less efficient retrofits. Guidelines for more sustainable material selection have advanced, but regulation and enforcement remain weak. We conclude by discussing all these challenges and providing a set of recommended actions in new initiatives.
Are Cities Safer Than Before?
Authors: Huang Guangwei
Published: July 2021

Cities are built to lead better lives. However, irrational urban development has led in reverse, causing numerous problems. The increase in flood risk in urbanized areas is one of the significant problems. Despite extensive research, numerous engineering projects have been carried out to reduce the risk of flooding, the question “are we safer than before?” remains underexplored. The present work is a case study aimed at providing new evidence of the current state of flood disaster management. It analyzed the relationship between the magnitude of flood and resultant flood fatality and property damage in the target area over a long period of time and found that we are safer now than before in terms of life loss, but not safer than before in terms of flooding impacts on livelihood. Most importantly, it was found that flood risk management in the region continues to be critically dependent on structural measures. Besides, it highlighted a contrast between having a well-developed emergency information delivery system and its ineffectiveness in mobilizing evacuation.
The English Government Hits Limits: Knowledge Politics and Covid-19
Authors: May Tim
Published: July 2021

Tragic its consequences, the Covid-19 pandemic has ripped through societies with, at the time of writing, global death rates exceeding two and a half million people. In the process, there has been variability in terms of how effectively governments have dealt with the pandemic. Differences between political responses, forms of governance and the relationships between science and politics are apparent. This article investigates these relations in the United Kingdom with a particular focus upon the interpretations that informed the response of the English Government and their interactions with the scientific community. For this purpose, it provides an exploration of the political and socio-economic conditions prevailing in the United Kingdom prior to the pandemic. It then examines the interactions between science and politics as the pandemic unfolded during 2020. Then, building on these discussions it views the tensions that arose through a clash between two characteristics within democratic societies: the redemptive and pragmatic. What becomes apparent is the tendency for a form of the redemptive to be favoured over the pragmatic which results in an exposure of limits to usual and narrow political ways of governing.