bluuebunny/crossref_metadata_2025 huggingface dataset:
Two-Stage Fermented Feather Meal-Soybean Meal Product Improves the Performance and Immunity of Lactating Sows and Piglets
Authors: Huang Hsien-Juang , Lee Yueh-Sheng , Weng Bor-Chun , Lin Cheng-Yung , Hsuuw Yan-Der , Chen Kuo-Lung
Published: January 2023

This study aimed to investigate the effects of a two-stage fermented feather meal-soybean meal product (TSFP) on the performance, clinical blood biochemistry, and immunity of sows and piglets. TSFP was fermented by Saccharomyces cerevisiae Y10 for three days in the second stage, which showed similar results to the five-day fermentation of B. coagulans (p > 0.05). Fifty hybrid sows (Duroc × KHAPS black pig) were randomly assigned into dietary supplementation groups of 2% fish meal or different levels of TSFP at 0%, 1%, 2%, or 3%. The results showed that body weight gain and feed conversion ratio of 2% and 3% TSFP groups were better than the control group and fish meal group during the gestation period (d 80–114) (p < 0.05). During the lactation period, the 3% TSFP group showed the best weaning litter weight (p < 0.05). In sows, interferon-γ and immunoglobulin G (IgG) of 2% and 3% TSFP groups were higher than the control group and fish meal group (p < 0.05). In piglets, in groups of 2% and 3% TSFP blood urea decreased (p < 0.05). The IgG of fermented groups was superior to the control group (p < 0.05). The oxidative burst of phagocytes in the 3% TSFP was higher than those of the control and fish meal groups (p < 0.05). In conclusion, TSFP supplementation exhibits the advantages of performance and immunity of lactating sows and piglets. Furthermore, adding 3% TSFP in the feed showed the best performance.
Synthesis and Degradation Properties of Sericin/PVA Hydrogels
Authors: Ekasurya William , Sebastian Joses , Puspitasari Dita , Asri Putri P. P. , Asri Lia A. T. W.
Published: January 2023

One method of treating diabetic foot ulcers, mainly superficial and deep ulcers, is using a wound dressing in the form of a hydrogel. Sericin derived from silkworm cocoons is a promising hydrogel material candidate because it has anti-inflammatory properties and stimulates collagen production. Sericin was combined with PVA to increase the stability of the resulting hydrogel. Sericin/PVA hydrogel was prepared using the freeze–thawing method with variations in the solution concentration and volume ratio of PVA and sericin. Sericin was successfully extracted using an autoclave method. The FTIR results confirmed that sericin extracted from the cocoon had a dominant secondary structure in the form of a β-sheet. Hydrogel with a concentration of 4% with a 1:1 ratio of PVA and sericin showed good stability and resulted in a hydrogel with characteristics that combine PVA and sericin. The resulting hydrogel had an average pore size range of 24–191 µm and a porosity range of 70–85%, which meets the requirements for wound dressings. Through degradation testing in PBS solution, it was found that the sericin/PVA hydrogel experienced degradation of 60–75% after 672 h of testing.
Advances in Vertebrate (Cyto)Genomics Shed New Light on Fish Compositional Genome Evolution
Authors: Matoulek Dominik , Ježek Bruno , Vohnoutová Marta , Symonová Radka
Published: January 2023

Cytogenetic and compositional studies considered fish genomes rather poor in guanine-cytosine content (GC%) because of a putative “sharp increase in genic GC% during the evolution of higher vertebrates”. However, the available genomic data have not been exploited to confirm this viewpoint. In contrast, further misunderstandings in GC%, mostly of fish genomes, originated from a misapprehension of the current flood of data. Utilizing public databases, we calculated the GC% in animal genomes of three different, technically well-established fractions: DNA (entire genome), cDNA (complementary DNA), and cds (exons). Our results across chordates help set borders of GC% values that are still incorrect in literature and show: (i) fish in their immense diversity possess comparably GC-rich (or even GC-richer) genomes as higher vertebrates, and fish exons are GC-enriched among vertebrates; (ii) animal genomes generally show a GC-enrichment from the DNA, over cDNA, to the cds level (i.e., not only the higher vertebrates); (iii) fish and invertebrates show a broad(er) inter-quartile range in GC%, while avian and mammalian genomes are more constrained in their GC%. These results indicate no sharp increase in the GC% of genes during the transition to higher vertebrates, as stated and numerously repeated before. We present our results in 2D and 3D space to explore the compositional genome landscape and prepared an online platform to explore the AT/GC compositional genome evolution.
Involvement of Mitochondrial Dysfunction in FOXG1 Syndrome
Authors: Bjerregaard Victoria A. , Levy Amanda M. , Batz Mille S. , Salehi Ravina , Hildonen Mathis , Hammer Trine B. , Møller Rikke S. , Desler Claus , Tümer Zeynep
Published: January 2023

FOXG1 (Forkhead box g1) syndrome is a neurodevelopmental disorder caused by a defective transcription factor, FOXG1, important for normal brain development and function. As FOXG1 syndrome and mitochondrial disorders have shared symptoms and FOXG1 regulates mitochondrial function, we investigated whether defective FOXG1 leads to mitochondrial dysfunction in five individuals with FOXG1 variants compared to controls (n = 6). We observed a significant decrease in mitochondrial content and adenosine triphosphate (ATP) levels and morphological changes in mitochondrial network in the fibroblasts of affected individuals, indicating involvement of mitochondrial dysfunction in FOXG1 syndrome pathogenesis. Further investigations are warranted to elucidate how FOXG1 deficiency impairs mitochondrial homeostasis.
The Unexpected Discovery of Syngenite on Margarito d’Arezzo’s The Virgin and Child Enthroned, with Scenes of the Nativity and the Lives of the Saints (Probably 1263–4) and Its Possible Use as a Yellow Lake Substrate
Authors: Peggie David , Howard Helen , Kirby Jo , Najorka Jens
Published: January 2023

The oldest painting in the National Gallery collection, The Virgin and Child Enthroned by Margarito d’Arezzo (NG564), dated to about 1263–4, depicts the Virgin and Child in a mandorla, surrounded by scenes of the Nativity and lives of the saints, set within red and decorative black borders, against a gilded background. The materials and technique were investigated using a combination of non-invasive techniques, such as Fibre Optic Reflectance Spectroscopy (FORS) and macro X-ray fluorescence scanning (MA-XRF), and the analysis of a small number of paint samples using energy dispersive X-ray analysis in the scanning electron microscope (SEM-EDS), High-Performance Liquid Chromatography (HPLC), Attenuated Total Reflectance—Fourier transform infrared spectroscopy (ATR-FTIR) and micro X-ray Diffraction (micro-XRD). The results provided evidence for the use of a number of organic colourants, with both indigo and red lake pigments identified. The finding of an unusual compound, syngenite (K2Ca(SO4)2·H2O), is here postulated as a potential substrate for an organic yellow lake pigment. In addition, reference pigments were prepared to explore this hypothesis. Although documentary evidence confirms that yellow lakes were being produced from an early date, there is very little direct evidence for their use in 13th-century panel paintings.
Polycyclic Aromatic Hydrocarbons (PAHs) Contamination in Chrysichthys nigrodigitatus Lacépède, 1803 from Lake Togo-Lagoon of Aného, Togo: Possible Human Health Risk Suitable to Their Consumption
Authors: Ouro-Sama Kamilou , Tanouayi Gnon , Solitoke Hodabalo Dheoulaba , Barsan Narcis , Mosnegutu Emilian , Badassan Tchaa Esso-Essinam , Agbere Sadikou , Adje Koudjo , Nedeff Valentin , Gnandi Kissao
Published: January 2023

The Lake Togo-Lagoon of Aného is located in the coastal zone where phosphorite mining is carried out. This mining discharges all kinds of waste such as fuel oil into the surrounding environment without prior treatment. Moreover, the hydrosystem receives runoff and river inputs after having crossed and leached from mining and urban soils. This study aims to determine the polycyclic aromatic hydrocarbons (PAHs) contamination in commercially consumed fish species (Chrysichthys nigrodigitatus) from that hydrosystem and the associated health risks for consumers. For that, fish sample collection was performed during the dry season. Afterwards, their muscles, gills, and livers were cut and 12 PAHs were analyzed using gas chromatography coupled with a mass spectrometer (GC-MS). The total PAHs (tPAHs) concentrations in fish tissues ranged from 5.24 to 48.40 µg/kg with average concentration of 14.51 ± 8.95 µg/kg in muscles, from 5.90 to 28.20 µg/kg averaging 14.90 ± 5.19 µg/kg in gills, and from 43.20 to 149.00 µg/kg with an average of 80.74 ± 27.08 µg/kg in livers. The average concentrations of low molecular weight PAHs (LMW PAHs) were 10.82 ± 9.61 µg/kg in muscles, 8.25 ± 5.43 µg/kg in gills, and 47.97 ± 22.56 µg/kg in livers whereas those of high molecular weight of PAHs (HMW PAHs) were 4.10 ± 2.14 µg/kg in muscles, 7.98 ± 3.96 µg/kg in gills, and 32.77 ± 8.66 µg/kg in livers. An overall trend of decreasing concentrations with increasing fish size classes was observed for some PAHs (Naphtalene, Pyrene in muscles, for Pyrene, Benzo(a)Anthracene, Chrysene in gills and for Naphtalene, Phenanthrene in livers). The PAHs in these fish might have pyrogenic and petrogenic sources, with the dominance of pyrogenic, and all of the total hazard quotients (THQ) are less than 1. This situation must not be neglected for better planning sustainable management of the target ecosystem.
Characterization of Fertility Clinic Attendees in the Abu Dhabi Emirate, United Arab Emirates: A Cross-Sectional Study
Authors: Abdo Noor Motea , Ahmad Hafiz , Loney Tom , Zarmakoupis Panayota Napoleon , Aslam Irfan , Irfan Shazia , Grivna Michal , Ahmed Luai A. , Al-Rifai Rami H.
Published: January 2023

This study describes the primary and secondary infertility in patients attending fertility clinics and reports factors associated with primary infertility. A cross-sectional survey was conducted in two fertility clinics in Abu Dhabi Emirate, United Arab Emirates (UAE) between December 2020 and May 2021. The collected information covered sociodemographic, lifestyle, medical, and fertility-related characteristics. The mean age and age at marriage (±SD) of the 928 patients were 35.7 (±6.7) and 25.2 (±6.3) years, respectively. Of the total, 72.0% were obese and overweight, 26.6% reported a consanguineous marriage, and 12.5% were smokers. Secondary infertility (62.5%) was more frequent than primary infertility (37.5%). Primary infertility was inversely associated with age (aOR, 0.94, 95% CI: 0.91–0.98) and not being overweight (aOR, 0.6, 95% CI: 0.4–0.9) while positively associated with a nationality other than Middle Eastern nationality (aOR, 1.9, 95% CI: 1.1–3.3), married for ≤5 years (aOR, 6.0, 95% CI: 3.9–9.3), in a nonconsanguineous marriage (aOR, 2.4, 95% CI: 1.5–3.9), having a respiratory disease (aOR, 2.3, 95% CI: 1.1–4.6), an increased age at puberty (aOR, 1.2, 95% CI: 1.0–1.3), and self-reported 6–<12 months (aOR, 2.4, 95% CI: 1.2–5.1) and ≥12 months (aOR, 3.4, 95% CI: 1.8–6.4) infertility. Patients with primary infertility were more likely to be diagnosed with infertility of an ovulation, tubal, or uterine origin (aOR, 3.9, 95% CI: 1.9–7.9). Secondary infertility was more common than primary infertility. Several preventable fertility-related risk factors including overweight, smoking, and diabetes were found to be common among the fertility clinic attendees.
Training Scientific Communication Skills on Medical Imaging within the Virtual World Second Life: Perception of Biomedical Engineering Students
Authors: Lozano-Durán Andrés , Rudolphi-Solero Teodoro , Nava-Baro Enrique , Ruiz-Gómez Miguel , Sendra-Portero Francisco
Published: January 2023

Second Life is a multi-user virtual world platform which enables online learning through immersive activities. This study evaluates the perception of third-year biomedical engineering students about learning activities complementary to a biomedical imaging course carried out within Second Life and focused on training in the public presentation of scientific content to their peers. Between 2015 and 2017, students gave oral presentations on medical imaging topics selected from the proposals of their classmates. Participants were invited to complete an evaluation questionnaire. In the three years of the study, 133 students enrolled in the course (48, 46, and 39 consecutively), and 97 of them delivered the questionnaire (48%, 83%, and 92%, consecutively). Attendance at the sessions ranged between 88% and 44%. The students positively value the experiences, especially the teacher, the educational content, and the virtual island environment, with mean scores greater than or equal to 8.4, 7.7, and 7.7, respectively, on a 1–10-point scale. Overall, they valued Second Life as an attractive and suitable environment for their training in science communication skills, in which they gain self-confidence and are less afraid of speaking in public. Second Life enables students to present scientific content effectively to their peers, receiving hands-on training in the tasks of collecting, organizing, and presenting data, with the benefits of remote access, collaborative work, and social interaction.
Evaluation of Six Years of Appropriateness Level of Blood Transfusion in a Pediatric Ward
Authors: Perrone Pier Mario , Milani Gregorio Paolo , Dellepiane Rosa Maria , Petaccia Antonella , Prati Daniele , Agostoni Carlo , Marchisio Paola Giovanna , Castaldi Silvana
Published: January 2023

Background: Blood transfusion can be considered as a life-saving treatment and is a primary health management topic. This study aims to assess the appropriateness of blood transfusion performed in a large tertiary hospital in Italy. Methods: a multispecialist team composed oof hematologists, public health experts and pediatricians analyzed blood transfusions performed between 2018 and 2022 in the pediatric wards comparing the appropriateness with the available NHS guidelines available. Patients’ characteristics, clinical features and blood component’s data were collected and analyzed. Results: considering 147 blood transfusions performed in 2018–2022, only eight (5.4%) were performed according to guidelines, while 98 (66.7%) were driven by clinicians’ expertise, especially for anemia in genetic syndromes (30) (20.5%) and autoimmune diseases (20) (13.6%). Thirty-nine (26.5%) transfusions could be considered as inappropriate, while two (1.4%) blood packs were never been transfused after being requested. Conclusions: This analysis is one of the first performed to assess the appropriateness of blood component transfusions comparing their compliance to NHS guidelines. The importance of this analysis can be explained first by the clinical point of view and second by the economic one.
Quality of Life and Side Effects Management in Cancer Treatment—A Cross Sectional Study
Authors: Llamas-Ramos Inés , Alvarado-Omenat Jorge Juan , Rodrigo-Reguilón María , Llamas-Ramos Rocío
Published: January 2023

Cancer disease is a world problem which is increasing in its prevalence. Oncology patients have a multitude of symptoms derived from the treatments and from the disease itself that affect their quality of life to a greater or lesser extent. The aim of this study has been to discover the physical and psychological symptoms related to chemotherapy treatment in Spanish cancer patients in order to improve their quality of life. Symptoms from the previous week were taken into account and the Memorial Symptom Assessment Scale was used to measure the frequency, severity and associated distress of 32 symptoms. A total of 246 chemotherapy patients at the University Day Hospital in Salamanca completed the scale once while receiving chemotherapy treatment. A 95% confidence interval was considered. The most prevalent symptoms were a lack of energy (76.4%), anxiety (66.7%) and a dry mouth (60.6%). Lung cancer was the most prevalent cancer in men (26%) and breast cancer was the most prevalent cancer in women (72%). There is no consensus on which is the most prevalent symptom in this population and more studies will need to be carried out to determine the best treatment protocols. Symptom’s prevalence knowledge could improve the patients’ care to prevent or avoid complications and to improve the cancer patients’ quality of life.
The Impact of Environmental Regulations on Pollution and Carbon Reduction in the Yellow River Basin, China
Authors: Liu Chengqing , Yang Dan , Sun Jun , Cheng Yu
Published: January 2023

Based on data from 69 cities in the Yellow River Basin from 2006–2018, this paper examines the impact of environmental regulations on the integrated management of air pollution and CO2 emissions and its mechanism of action using a two-way stationary model. The results found that: (1) The impact of environmental regulations on air pollution and CO2 emissions in the Yellow River Basin has an inverted U-shaped trend, the intensity of regulation is still on the left side of the inverted U-shaped curve, and the inflection point has not yet appeared. (2) Environmental regulations suppressed air pollution and CO2 emissions by adjusting industrial structure, promoting technological innovation, and improving energy efficiency, but the current intensity of regulation is not sufficient to make the three paths fully effective. (3) The pollution and carbon reduction effects of environmental regulations are more significant in areas with higher marketization and resource dependence, national urban agglomerations, and the middle reaches of the Yellow River Basin. However, environmental regulations in other regions only show significant pollution reduction effects, and there is still more room for improving carbon reduction governance. Therefore, the Yellow River Basin should strengthen environmental regulations to promote ecological governance and high-quality development.
Towards an Understanding of Successes of the Psychiatric Nurses in Caring for Children with Mental Health Problems: An Appreciative Inquiry
Authors: Machailo Rorisang Mary , Koen Daleen , Matsipane Molekodi
Published: January 2023

Introduction: Psychiatric nurses have a specialized body of knowledge and skills in providing care to persons with mental health challenges. The literature provides scanty evidence on child psychiatric nursing practices. This paper explored the successes of psychiatric nurses in caring for children with mental health problems using appreciative inquiry (AI). Design: A qualitative exploratory and descriptive design was used to allow for new ideas that can fundamentally reshape the practice of child psychiatric nursing. Purposive sampling was used to select psychiatric nurses caring for children with mental health problems. Focus groups were used to generate data. Findings: The results indicate both positive and negative prospects for psychiatric nursing practice. The positive possibilities included commitment, passion and dedication of staff to the children. The negative aspects that need urgent attention include lack of specific, integrated child mental health within the mental health care services, shortage of resources and not-fit-for purpose infrastructure. Conclusion: Appreciative inquiry verified the commitment of psychiatric nurses in caring for children with mental health problems and the potential for dedicated child psychiatric institutions in realizing the needs of such children. The needs of children with mental health problems must be addressed through positive care in the health system.
Differences in Physical Activity, Sedentary Behavior, and Mental Health of the Older Population in South Korea Based on Marital Status and Gender
Authors: Park Jeong-Hui , Prochnow Tyler , Amo Christina , Curran Laurel , Smith Matthew Lee
Published: January 2023

The primary purpose of the present study was to assess differences in physical activity (PA), sedentary behavior (SB), and mental health (i.e., depression, suicidal thoughts, and cognitive function) by marital status (i.e., married and widowed) within an aging population in South Korea. PA, SB, and mental health were evaluated in 9092 older adults by comparing the married group (n = 5773, 73.2 ± 5.9 years, 63.5%) to the widowed group (n = 3319, 75.8 ± 6.8 years, 36.5%). Between-group differences in PA, SB, depression, and cognitive function were tested using independent t-tests, and the association between marital status and gender was evaluated using two-way ANOVA. Suicidal thoughts were analyzed using a Mann–Whitney U-test. Older adults in the widowed group participated in significantly less PA (p < 0.001) and had higher SB (p < 0.001) per week, especially the widows, who had significantly less PA (p < 0.01) and had higher SB (p < 0.001) compared to married women. Participants in the widowed group experienced more depression (p < 0.001) and suicidal thoughts (p < 0.001) and had significantly lower cognitive function compared to participants in the married group (p < 0.001). Between the two groups, widowers were more vulnerable to all mental health factors compared to those in the married group. At the same time, widows were only more vulnerable to depression and cognitive function compared to women in the married group. Findings indicated that the presence of a spouse is strongly associated with higher PA levels, lower SB, and better mental health among older adults. Spouses are the primary social supports and play a major role in the health and emotional well-being of the aging population. Given the importance of the spouse, our study suggests that health educators working with older widows should prioritize several different forms of social support to benefit their physical and mental health.
The Bidirectional Relationship between Chronic Kidney Disease and Hyperuricemia: Evidence from a Population-Based Prospective Cohort Study
Authors: Ma Zhibin , Wang Xiao , Zhang Jia , Yang Chao , Du Hongmei , Dou Feng , Li Jianjian , Zhao Yini , Quan Peiqin , Hu Xiaobin
Published: January 2023

Background. Although several studies have examined the association between chronic kidney disease (CKD) and hyperuricemia (HUA), the direction of the association remains unclear. We aimed to investigate whether there was a bidirectional association between them. Methods. The present study was conducted in three analyses. Analysis I included 25,433 participants free of HUA at baseline to evaluate the associations between CKD and estimated glomerular filtration rate (eGFR) with incident HUA. Analysis II had 28,422 participants free of CKD at baseline to analyze the relationships between HUA and serum uric acid (sUA) with new-onset CKD. Cox proportional hazards regression models were applied to evaluate the association involved in Analysis I and II. Analysis III included 31,028 participants with complete data and further dissected the bidirectional association between sUA and eGFR using cross-lag models. Results. New-onset HUA and CKD were observed in the first round of the follow-up study among 1597 and 1212 participants, respectively. A significantly higher risk of HUA was observed in individuals with CKD compared to individuals without CKD (HR = 1.58, 95% CI: 1.28–1.95). The adjusted HRs (95% CIs) of HUA were 3.56 (2.50–5.05) for the participants in the group of eGFR less than 60 mL·min−1·1.73 m−2, 1.61 (1.42–1.83) for those in the group of eGFR between 60 and 90 mL·min−1·1.73 m−2, and 1.74 (1.42–2.14) for those in the group of eGFR more than 120 mL·min−1·1.73 m−2, compared with the group of eGFR between 90 and 120 mL·min−1·1.73 m−2. A higher risk of CKD was also observed in individuals with HUA compared to individuals without HUA (HR = 1.28, 95% CI: 1.12–1.47). Compared with the first quintile of sUA, the adjusted HR (95% CI) of CKD was 1.24 (1.01–1.51) for the participants in the fourth quantile. There was a bidirectional relationship between sUA and eGFR, with the path coefficients (ρ1 = −0.024, p < 0.001) from baseline eGFR to follow-up sUA and the path coefficients (ρ2 = −0.015, p = 0.002) from baseline sUA to follow-up eGFR. Conclusions. The present study indicated that CKD and HUA were closely associated, and there was a bidirectional relationship between sUA and eGFR.
Polish Adaptation of the Alarm Fatigue Assessment Questionnaire as an Element of Improving Patient Safety
Authors: Rypicz Łukasz , Rozensztrauch Anna , Fedorowicz Olga , Włodarczyk Aleksander , Zatońska Katarzyna , Juárez-Vela Raúl , Witczak Izabela
Published: January 2023

Medical personnel, working in medical intensive care units, are exposed to fatigue associated with alarms emitted by numerous medical devices used for diagnosing, treating, and monitoring patients. Alarm fatigue is a safety and quality problem in patient care and actions should be taken to reduce this by, among other measures, building an effective safety culture. In the present study, an adaptation of a questionnaire to assess alarm fatigue was carried out. The study obtained good reliability of the questionnaire at Cronbach’s alpha level of 0.88. The Polish research team has successfully adapted the Alarm Fatigue Assessment Questionnaire so that it can be used in healthcare settings as a tool to improve patient safety.
Social and Metabolic Determinants of Prevalent Hypertension in Men and Women: A Cluster Analysis from a Population-Based Study
Authors: Bala Cornelia , Rusu Adriana , Gheorghe-Fronea Oana Florentina , Benedek Theodora , Pop Calin , Vijiiac Aura Elena , Stanciulescu Diana , Darabantiu Dan , Roman Gabriela , Dorobantu Maria
Published: January 2023

Essential hypertension (HTN) has a complex spectrum of pathophysiological determinants and current guidelines provide limited information on high-risk groups that should be targeted for its primary prevention. The objective of our research was to identify clusters of social and metabolic factors associated with prevalent HTN in men and women from a population-based survey in Romania. Of the 1477 participants in the main study, 798 with complete data were analyzed here. Using two-step cluster analysis, one high-risk cluster in women and two high and intermediate risk for prevalent HTN in men were identified. Older age, rural area, lower education, and higher burden of metabolic factors characterized clusters with higher risk, while intermediate risk in men was characterized by a more metabolically healthy phenotype in younger individuals. In logistic regression, men in Cluster 1 vs. those in Cluster 3 had an odds ratio (OR) of 9.6 (95%CI: 4.6; 20.0), p < 0.001 for prevalent HTN, while OR for Cluster 2 vs. Cluster 3 was 3.2 (95%CI: 1.4; 7.4), p = 0.005. In women, the OR for HTN was 10.2 (95%CI: 5.7; 18.5) if assigned to Cluster 2 vs. Cluster 1, p < 0.001. These results pointed out the subgroups and communities that the primary prevention of HTN should be prioritized in.
The Impact of the COVID-19 Pandemic on the Mental Health of Teachers and Its Possible Risk Factors: A Systematic Review
Authors: Santiago Iago Sávyo Duarte , dos Santos Emanuelle Pereira , da Silva José Arinelson , de Sousa Cavalcante Yuri , Gonçalves Júnior Jucier , de Souza Costa Angélica Rodrigues , Cândido Estelita Lima
Published: January 2023

(1) Objective: The objective was to analyze the development of psychiatric pathologies/burnout syndrome and their possible risk factors in teachers in the context of the COVID-19 pandemic. (2) Methods: A qualitative systematic review was carried out, according to the PRISMA protocol, in the PubMed, Scopus, and Web of Science databases using a combination of the following descriptors [MeSH]: “mental health”, “mental disorders’’, “covid-19” and “school teachers’’. Articles selected were written in English, Portuguese and Spanish, published between November 2019 and December 2022. (3) Results: The most common psychiatric pathologies were generalized anxiety disorders and depression. Burnout syndrome was also quite prevalent. Of the 776 articles identified, 42 were selected after applying the eligibility criteria. Although there is variability among the analyzed studies, the risk factors most correlated with increased morbidity in teachers were: (i) being female; (ii) age below the fifth decade of life; (iii) pre-existence of chronic or psychiatric illnesses before the pandemic; (iv) difficulty in adapting to the distance education model; (v) family/work conflicts; (vi) negative symptoms caused by the pandemic. (4) Conclusions: Therefore, the COVID-19 impact on mental health appears to be more common in female teachers in their fifth decade of life and with pre-existing psychiatric comorbidities. However, prospective studies are needed to better map this situation.
User Evaluation of Thematic Maps on Operational Areas of Rescue Helicopters
Authors: Wielebski Łukasz , Medyńska-Gulij Beata
Published: January 2023

This article presents the results of research on users concerning six thematic maps made with various mapping techniques and related to various aspects of the activities of the Helicopter Emergency Medical Service. The aim of the survey was to determine how the respondents rank these maps in terms of the four subjective evaluation criteria, which were the graphical attractiveness of maps, the readability of maps, the usefulness and importance of information, and the complexity of information presented on the maps. The greatest discrepancies were noted for the dot map, while the flow map obtained the most consistent evaluations. To check what the respondents were guided by while building the ranking for each criterion, a catalog of factors was created, the importance of which was assessed using the Likert scale. In the case of graphical attractiveness, users attach particular importance to the arrangement of objects visible on the map. The speed of reading the information is particularly important for map readability. In the case of the usefulness and importance of the information, the map topic, important for saving health and life from the user’s point of view, was of the greatest importance, while the amount of information in the legend significantly influenced the evaluation of information complexity.
News Recommendation Based on User Topic and Entity Preferences in Historical Behavior
Authors: Zhang Haojie , Shen Zhidong
Published: January 2023

A news-recommendation system is designed to deal with massive amounts of news and provide personalized recommendations for users. Accurately modeling of news and users is the key to news recommendation. Researchers usually use auxiliary information such as social networks or item attributes to learn about news and user representation. However, existing recommendation systems neglect to explore the rich topics in the news. This paper considered the knowledge graph as the source of side information. Meanwhile, we used user topic preferences to improve recommendation performance. We proposed a new framework called NRTEH that was based on topic and entity preferences in user historical behavior. The core of our approach was the news encoder and the user encoder. Two encoders in NRTEH handled news titles from two perspectives to obtain news and user representation embedding: (1) extracting explicit and latent topic features from news and mining user preferences for them; and (2) extracting entities and propagating users’ potential preferences in the knowledge graph. Experiments on a real-world dataset validated the effectiveness and efficiency of our approach.
Host Transcriptome Analysis of Spodoptera frugiperda Larvae Parasitized by Microplitis manilae
Authors: Gulinuer Ahamaijiang , Xing Binglin , Yang Lei
Published: January 2023

It has been extensively found that parasitoids manipulate host physiology to benefit the survival and development of their offspring. However, the underlying regulatory mechanisms have not received much attention. To reveal the effects of parasitization of the larval solitary endoparasitoid Microplitis manilae (Hymenoptera: Braconidae) on host Spodoptera frugiperda (Lepidoptera: Noctuidae), one of the most destructive agricultural pests in China, deep-sequencing-based transcriptome analysis was conducted to compare the host gene expression levels after 2 h, 24 h, and 48 h parasitization. A total of 1861, 962, and 108 differentially expressed genes (DEGs) were obtained from the S. frugiperda larvae at 2 h, 24 h, and 48 h post-parasitization, respectively, compared with unparasitized controls. The changes in host gene expressions were most likely caused by the injection of wasp parasitic factors, including PDVs, that were injected along with the eggs during oviposition. Based on the functional annotations in GO and KEGG databases, we revealed that most DEGs were implicated in host metabolism and immunity. Further analysis of the common DEGs in three comparisons between the unparasitized and parasitized groups identified four genes, including one unknown and three prophenoloxidase (PPO) genes. Moreover, 46 and 7 common DEGs involved in host metabolism and immunity were identified at two or three time points after parasitization, respectively. Among these, most DEGs showed increased expressions at 2 h post-wasp parasitization while exhibiting significantly decreased expression levels at 24 h post-parasitization, demonstrating the expression regulations of M. manilae parasitization on host metabolism and immune-related genes. Further qPCR verification in 20 randomly selected DEGs confirmed the accuracy and reproducibility of the gene expression profiles generated from RNA-seq. This study reveals the molecular regulatory network about how host insects respond to wasp parasitism, laying a solid foundation for revealing the physiological manipulation of wasp parasitization on host insects, which facilitates the development of biological control practices for parasitoids.
Acknowledgment to the Reviewers of Journal of Cardiovascular Development and Disease in 2022
Authors:   Journal of Cardiovascular Development and Disease Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Comparing Temporary Immobilization Using Cast and External Fixator in Unimalleolar Ankle Fracture Dislocations: A Retrospective Case Series
Authors: Mandelka Eric , Wikanardi Bernhard A. , Beisemann Nils , Gruetzner Paul A. , Franke Jochen , Vetter Sven Y. , Privalov Maxim
Published: January 2023

Studies have reported a high percentage of ankle fracture dislocations with secondary loss of reduction during primary treatment with a splint or cast. This study aimed to assess the rate of secondary loss of reduction in unimalleolar ankle fracture dislocations treated primarily with a cast or external fixator, identify the potential influence of fracture morphology, and investigate the potential implications. Unimalleolar ankle fracture dislocations with and without posterior malleolar fracture between 2011 and 2020 were included. Patients were categorized into two groups, depending on the method of temporary treatment. Fracture morphology, time to definitive surgery, and soft-tissue complications were compared. Of 102 patients, loss of reduction tended to occur more often in the cast group (17.3%) than in the external fixator group (6.0%). The presence of a posterior malleolar fracture did not have a significant influence on loss of reduction in cast immobilization; however, the fragment proved to be significantly bigger in cases with loss of reduction. No statistically significant differences in soft tissue complications or time to definitive surgery were found. Surgeons should consider the application of interval external fixation in the primary treatment of unimalleolar ankle fracture dislocations with additional posterior malleolar fractures.
Effects of Concurrent, Within-Session, Aerobic and Resistance Exercise Training on Functional Capacity and Muscle Performance in Elderly Male Patients with Chronic Heart Failure
Authors: Volterrani Maurizio , Caminiti Giuseppe , Perrone Marco Alfonso , Cerrito Anna , Franchini Alessio , Manzi Vincenzo , Iellamo Ferdinando
Published: January 2023

Background. The best format of exercise training (ET) in the setting of cardiac rehabilitation in patients with chronic heart failure (CHF) is still to be defined. Current guidelines recommend aerobic exercises, such as running and cycling, including some sessions per week of resistance exercise. Aim. The aim of this study was to address the effectiveness of a concurrent exercise training program utilizing a circuit of sequential endurance and resistance exercises on functional capacity and muscular strength in patients with CHF. Methods. Ninety-five consecutive male patients (age 63.1 ± 6 years) with CHF (EF < 40%) in NYHA functional class II/III, were randomly assigned on 1:1 basis to a 12-week aerobic continuous training (AT) or concurrent CT), aerobic + resistance, training (CT), three times a week, with each session lasting 80 min. We used high quality, specifically designed ergometers, connected with each other and governed by a central console, and managed by a single physiotherapist. Before and after training all patients performed a symptoms-limited exercise test on a treadmill and a 6-min walking test (6MWT). Patients in the CT group also performed resistance exercises of upper and lower body. Results. The 6MWT and exercise duration at ergometric test increased significantly in both AT and CT groups, with the increase being greater in CT group (p < 0.001; ES = 0.13; p < 0.01; ES = 0.07). Muscular strength increased significantly in the CT group, particularly in the lower body muscular districts (p < 0.001). Quality of life improved in both groups, with a significantly greater improvement in the CT group (p < 0.05). No side effects leading to discontinuation of training were observed. Conclusions. These findings indicate that concurrent, within-session training results in larger improvements in functional capacity, in addition to muscle performance, in patients with CHF, in comparison to single-mode aerobic training.
Radiation Exposure and Surgical Outcomes after Antegrade Sclerotherapy for the Treatment of Varicocele in the Paediatric Population: A Single Centre Experience
Authors: Bebi Carolina , Bilato Marco , Minoli Dario Guido , De Marco Erika Adalgisa , Gnech Michele , Paraboschi Irene , Boeri Luca , Fulgheri Irene , Brambilla Roberto , Campoleoni Mauro , Albo Giancarlo , Montanari Emanuele , Manzoni Gianantonio , Berrettini Alfredo
Published: January 2023

Introduction: Antegrade sclerotherapy (Tauber) effectively treats varicocele. However, fluoroscopy exposes young males to ionizing radiation. We aimed to evaluate radiation exposure and surgical outcomes after the Tauber procedure. Materials and methods: We retrospectively analysed data from 251 patients. Dose area product (DAP) and fluoroscopy time were recorded. The effective dose was calculated with the PCXMC software. Descriptive statistics and linear regression tested the association between clinical predictors and radiation exposure. Results: Median (IQR) age and body mass index (BMI) were 14 (13–16) years and 20.1 (17.9–21.6) kg/m². Five (2.1%) patients developed clinical recurrence and two (0.81%) developed complications. Median fluoroscopy time and DAP were 38.5 (27.7–54.0) s and 89.6 (62.5–143.9) cGy*cm2. The effective dose was 0.19 (0.14–0.31) mSv. Fluoroscopy time was higher in patients with collateral veins (41 (26–49) s vs. 36 (31–61) s, p = 0.02). The median amount of sclerosing agent (SA) used was 3 (3–4) ml. DAP was higher when SA > 3 mL was used (101.4 (65–183) cGy*cm2 vs. 80.5 (59–119) cGy*cm2; p < 0.01). At univariable linear regression, age, BMI, operative time and SA > 3 mL were associated with higher DAP (all p < 0.01). At multivariable linear regression, only BMI (beta 12.9, p < 0.001) and operative time (beta 1.9, p < 0.01) emerged as predictors of higher DAP, after accounting for age and SA > 3 mL. Conclusions: The Tauber procedure is safe and associated with low effective doses. Operative time and the patient’s BMI independently predict a higher radiation dose.
Associations between Systemic Immune-Inflammation Index and Diabetes Mellitus Secondary to Pancreatic Ductal Adenocarcinoma
Authors: Chen Guanhua , Tan Chunlu , Liu Xubao , Wang Xing , Tan Qingquan , Chen Yonghua
Published: January 2023

Background: There is a high prevalence of diabetes mellitus (DM) in patients with pancreatic ductal adenocarcinoma (PDAC). An inflammatory response is considered as a potential mechanism involved in the process. The systemic immune-inflammation (SII) index is an integrated and novel inflammatory indicator developed in recent years. The purpose of this study was to determine the relationship between the SII and DM secondary to PDAC. Method: Patients with a confirmed diagnosis of PDAC were analyzed in this cross-sectional study. Anthropometric measures, glucose-related data (including fasting glucose, 2 h OGTT, glycated hemoglobin, fasting insulin, and fasting c-peptide), tumor characteristics (tumor volumes, location and stages), and the periphery blood inflammatory index (white blood cell count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and SII) were recorded. The inflammation index was analyzed for its association with glucose-related parameters. Multivariable logistic regression analysis was used to analyze the association between SII levels and DM secondary to PDAC. Results: Blood cell results showed that the white blood cell count, neutrophils, lymphocytes, monocytes, platelets, the neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were higher in patients with diabetes. It was worth noting that SII significantly increased in patients with diabetes secondary to PDAC (4.41 vs. 3.19, p < 0.0001). Multivariable logistic regression analysis showed that SII (OR: 2.024, 95%CI: 1.297, 3.157, p = 0.002) and age (OR: 1.043, 95%CI: 1.01, 1.077, p = 0.011) were the risk factors for DM secondary to PDAC after adjusting for covariates. According to Spearmen correlation analysis, SII was positively correlated with fasting glucose (r = 0.345, p < 0.0001), 2 h OGTT (r = 0.383, p < 0.0001), HbA1c (r = 0.211, p = 0.005), fasting insulin (r = 0.435, p < 0.0001), fasting C-peptide (r = 0.420, p < 0.0001), and HOMA2-IR (r = 0.491, p < 0.0001). Conclusions: In conclusion, SII is significantly increased among patients with DM secondary to PDAC and is associated with the DM in patients with PDAC (OR: 2.382, 95% CI: 1.157, 4.903, p = 0.019). Additionally, SII is significantly correlated with insulin resistance. We are the first to investigate the relationship between SII and diabetes secondary to PDAC and further confirm the role of an inflammatory response in this process. More studies need to be designed to clarify how inflammatory responses participate.
Computational Simulation Model to Predict Behavior Changes in Inflammatory Bowel Disease Patients during the COVID-19 Pandemic: Analysis of Two Regional Japanese Populations
Authors: Suzuki Gen , Iwakiri Ryuichi , Udagawa Eri , Ma Sindy , Takayama Ryoko , Nishiura Hiroshi , Nakamura Koshi , Burns Samuel P. , D’Alessandro Paul Michael , Fernandez Jovelle
Published: January 2023

Managing inflammatory bowel disease (IBD) is a major challenge for physicians and patients during the COVID-19 pandemic. To understand the impact of the pandemic on patient behaviors and disruptions in medical care, we used a combination of population-based modeling, system dynamics simulation, and linear optimization. Synthetic IBD populations in Tokyo and Hokkaido were created by localizing an existing US-based synthetic IBD population using data from the Ministry of Health, Labor, and Welfare in Japan. A clinical pathway of IBD-specific disease progression was constructed and calibrated using longitudinal claims data from JMDC Inc for patients with IBD before and during the COVID-19 pandemic. Key points considered for disruptions in patient behavior (demand) and medical care (supply) were diagnosis of new patients, clinic visits for new patients seeking care and diagnosed patients receiving continuous care, number of procedures, and the interval between procedures or biologic prescriptions. COVID-19 had a large initial impact and subsequent smaller impacts on demand and supply despite higher infection rates. Our population model (Behavior Predictor) and patient treatment simulation model (Demand Simulator) represent the dynamics of clinical care demand among patients with IBD in Japan, both in recapitulating historical demand curves and simulating future demand during disruption scenarios, such as pandemic, earthquake, and economic crisis.
Is Endothelial Activation a Critical Event in Thrombotic Thrombocytopenic Purpura?
Authors: Cauchois Raphael , Muller Romain , Lagarde Marie , Dignat-George Françoise , Tellier Edwige , Kaplanski Gilles
Published: January 2023

Thrombotic thrombocytopenic purpura (TTP) is a severe thrombotic microangiopathy. The current pathophysiologic paradigm suggests that the ADAMTS13 deficiency leads to Ultra Large-Von Willebrand Factor multimers accumulation with generation of disseminated microthrombi. Nevertheless, the role of endothelial cells in this pathology remains an issue. In this review, we discuss the various clinical, in vitro and in vivo experimental data that support the important role of the endothelium in this pathology, suggesting that ADAMTS13 deficiency may be a necessary but not sufficient condition to induce TTP. The “second hit” model suggests that in TTP, in addition to ADAMTS13 deficiency, endogenous or exogenous factors induce endothelial activation affecting mainly microvascular cells. This leads to Weibel–Palade bodies degranulation, resulting in UL-VWF accumulation in microcirculation. This endothelial activation seems to be worsened by various amplification loops, such as the complement system, nucleosomes and free heme.