bluuebunny/crossref_metadata_2025 huggingface dataset:
Trends in the Incidence, Treatment and Outcomes of Patients with Intrahepatic Cholangiocarcinoma in the USA: Facility Type is Associated with Margin Status, Use of Lymphadenectomy and Overall Survival
Authors: Wu Lu , Tsilimigras Diamantis I. , Paredes Anghela Z. , Mehta Rittal , Hyer J. Madison , Merath Katiuscha , Sahara Kota , Bagante Fabio , Beal Eliza W. , Shen Feng , Pawlik Timothy M.
Published: February 2019

Introduction

Intrahepatic cholangiocarcinoma (ICC) remains an uncommon disease with a rising incidence worldwide. We sought to identify trends in therapeutic approaches and differences in patient outcomes based on facility types.

Methods

Between January 1, 2004, and December 31, 2015, a total of 27,120 patients with histologic diagnosis of ICC were identified in the National Cancer Database and were enrolled in this study.

Results

The incidence of ICC patients increased from 1194 in 2004 to 3821 in 2015 with an average annual increase of 4.16% (p < 0.001). Median survival of the cohort improved over the last 6 years of the study period (2004–2009: 8.05 months vs. 2010–2015: 9.49 months; p < 0.001). Among surgical patients (n = 5943, 21.9%), the incidence of R0 resection, lymphadenectomy and harvest of ≥6 lymph nodes increased over time (p < 0.001). Positive surgical margins (referent R0: R1, HR 1.49, 95% CI 1.24–1.79, p < 0.001) and treatment at community cancer centers (referent academic centers; HR 1.24, 95% CI 1.04–1.49, p = 0.023) were associated with a worse prognosis. Patients treated at academic centers had higher rates of R0 resection (72.4% vs. 67.7%; p = 0.006) and lymphadenectomy (55.6% vs. 49.5%, p = 0.009) versus community cancer centers. Overall survival was also better at academic versus community cancer programs (median OS: 11 months versus 6 months, respectively; p < 0.001).

Conclusions

The incidence of ICC has increased over the last 12 years in the USA with a moderate improvement in survival over time. Treatment at academic cancer centers was associated with higher R0 resection and lymphadenectomy rates, as well as improved OS for patients with ICC.
Water, Sanitation, and Child Health: Evidence From Subnational Panel Data in 59 Countries
Authors: Headey Derek , Palloni Giordano
Published: February 2019

Water, sanitation, and hygiene (WASH) investments are widely seen as essential for improving health in early childhood. However, the experimental literature on WASH interventions identifies inconsistent impacts on child health outcomes, with relatively robust impacts on diarrhea and other symptoms of infection but weak and varying impacts on child nutrition. In contrast, observational research exploiting cross-sectional variation in water and sanitation access is much more sanguine, finding strong associations with diarrhea prevalence, mortality, and stunting. In practice, both literatures suffer from significant methodological limitations. Experimental WASH evaluations are often subject to poor compliance, rural bias, and short duration of exposure, while cross-sectional observational evidence may be highly vulnerable to omitted variables bias. To overcome some of the limitations of both literatures, we construct a panel of 442 subnational regions in 59 countries with multiple Demographic Health Surveys. Using this large subnational panel, we implement difference-in-difference regressions that allow us to examine whether longer-term changes in water and sanitation at the subnational level predict improvements in child morbidity, mortality, and nutrition. We find results that are partially consistent with both literatures. Improved water access is statistically insignificantly associated with most outcomes, although water piped into the home predicts reductions in child stunting. Improvements in sanitation predict large reductions in diarrhea prevalence and child mortality but are not associated with changes in stunting or wasting. We estimate that sanitation improvements can account for just under 10 % of the decline in child mortality from 1990 to 2015.
Type 1 diabetes mellitus in Gabon
Authors: Damiens Armelle Pambou , Ganga-Zandzou Patrice Serge , Ibounde Eudine Tsoucka , Kayemba-Kay's Simon , Baye Eric , Biloghe Peggy , Kakou Chantal , Ntyonga-Pono Pierrette
Published: February 2019

Background and Objective

Type 1 diabetes mellitus (T1DM) is the most frequent endocrinopathy in children. Its replacement therapy requires insulin, without which, death is inevitable. This treatment is expensive and a financial burden for diabetic children and their families, especially in Africa.

In the absence of a national T1DM register, the purpose of this study was to describe epidemiological aspects of type 1 diabetes in children in Gabon, specify the difficulties met by the patients during the follow-up and identify factors explaining poor therapeutic observance and metabolic control.

Material and methods

Prospective transversal monocentric study. Data were firstly extracted from the registers of the Endocrinology Department of the University Hospital of Libreville (CHUL), Gabon, between 2010 and 2017.

Secondly, patients were interviewed by telephone about the availability and cost of insulin, their self-monitoring of blood glucose, and diet.

Results

306 patients (154 girls and 152 boys) were diagnosed with T1D during the study period and followed-up in the Endocrinology Department at CHUL. Mean age at diagnosis was 17 ± 7 years (5% of patients were over 5 years of age, 30% were >20 years old). Mean follow-up period was 4.0 ± 2.0 years. 16% of the patients were hospitalized at least 2 times per month for ketoacidosis.

Hospital mortality was about 7%. Number of factors linked with poor therapeutic observance (high cost of treatment, lack of patients’ therapeutic education, etc.) were identified.

Conclusion

T1D prevalence is constantly increasing worldwide, but at slower pace in Africa in comparison to developed countries. Difficulties to access to high standard care and population poverty in Sub-Saharan Africa, represents a major independent factor of poor therapeutic observance.
Effects of the dual orexin receptor antagonist DORA‐22 on sleep in 5XFAD mice
Authors: Duncan Marilyn J. , Farlow Hannah , Tirumalaraju Chairtra , Yun Do‐Hyun , Wang Chanung , Howard James A. , Sanden Madison N. , O'Hara Bruce F. , McQuerry Kristen J. , Bachstetter Adam D.
Published: February 2019

Introduction

Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD‐relevant mouse model, 5XFAD.

Methods

Wild‐type (C57Bl6/SJL) and 5XFAD mice received chronic treatment with vehicle or DORA‐22. Piezoelectric recordings monitored sleep and spatial memory was assessed via spontaneous Y‐maze alternations. Aβ plaques, Aβ levels, and neuroinflammatory markers were measured by immunohistochemistry, enzyme‐linked immunosorbent assay, and real‐time polymerase chain reaction, respectively.

Results

In 5XFAD mice, DORA‐22 significantly increased light‐phase sleep without reducing Aβ levels, plaque density, or neuroinflammation. Effects of DORA‐22 on cognitive deficits could not be determined because the 5XFAD mice did not exhibit deficits.

Discussion

These findings suggest that DORAs may improve sleep in AD patients. Further investigations should optimize the dose and duration of DORA‐22 treatment and explore additional AD‐relevant animal models and cognitive tests.
Harnessing the Power of Positive Parenting to Promote Wellbeing of Children, Parents and Communities Over a Lifetime
Authors: Sanders Matthew R.
Published: February 2019

Evidence-based parenting support (EBPS) programs derived from social learning theory, cognitive behavioural principles, and developmental theory are among the most successful innovations in the entire field of psychological intervention. EBPS programs have been at the cutting edge of global dissemination efforts to increase community access to evidence-based parenting programs. Despite the widely recognised success of these efforts, existing models of parenting intervention are not a panacea, and much can be done to improved outcomes. Efforts to improve outcomes have included the emergence of a population-based approach to increase reach of intervention. This has included the development of flexible delivery modalities, including online parenting interventions, the incorporation of strategies to enhance cultural relevance and acceptability of programs, and more recently, applications with parents in very low resource settings. Further enhancements of outcomes are likely to be forthcoming as we gain a better understanding of the mechanisms that explain positive intervention effects and non-response to interventions. More cost-effective online professional training models are needed to disseminate and promote the sustained use of EBPS programs. New interventions are required for the most vulnerable parents when parenting concerns are complicated by other problems such as trauma, addictions, relationship conflict, family violence, mental health problems and intergenerational poverty. However, to scale effective programs, Commonwealth and state government policies and funding priorities need to respond to evidence about what works and make sustained investments in the implementation of parenting programs. Possible strategies to enhance the policy impact of intervention research are discussed.
Falsolikanella campanensis(Azéma and Jaffrezo, 1972) Granier, 1987 revisited on type material, evidence of polyphysacean nature (green algae)
Authors: Barattolo Filippo , Carras Nicola , Conrad Marc André , Radoičić Rajka
Published: February 2019

The genusFalsolikanella, introduced by Granier (1987), was based on the basal Cretaceous speciesLikanella campanensisAzéma and Jaffrezo (1972) and assigned to the tribe Diploporeae (Pia, 1920) emend. Güvenc, 1979 within the green alga order Dasycladales. Later, other species were assigned toFalsolikanella. Sections of the type specimens ofLikanella campanensisare reviewed. They show that in this species, the arrangement of the laterals is not metaspondyl, but typical of the genusActinoporella(Gümbel in Alth, 1882) emend Conrad, Praturlon, and Radoičić, 1974, with coronae arising from a single primary lateral. Therefore, the species is assigned to the genusActinoporellawithin the tribe Acetabularieae Decaisne, 1842, family Polyphysaceae Kützing, 1843, and the generic attribution of other species previously assigned toFalsolikanellais discussed.
Pennsylvanian sponge from the Mecca Quarry Shale, Carbondale Group (Indiana, USA) and the paleobiogeographic distribution ofTeganiellain the paleoequatorial region of Laurentia
Authors: Mouro Lucas D. , Horodyski Rodrigo S. , Fernandes Antonio. C.S. , Carvalho Marcelo A. , Silva Mateus. S. , Waichel Breno L. , Saldanha João P.
Published: February 2019

The sponges may be the oldest group of Metazoa, with a long and successful evolutionary history. Despite their intermittent fossil record quality, the group has been considered reliable for paleoecological and paleobiogeographic analyses because they have inhabited various types of aquatic environments, forming a significant part of benthic communities. We have presented a detailed description of a new species from the genusTeganiella,Teganiella finksinew species, which expands the chronologic range and classifies the genus as endemic to the paleoequatorial regions of Laurentia associated with arid climate conditions linked to hypersaline periods. Combining the paleoecological and paleoenvironmental features of theTeganiellaspecies, our findings also suggest a trend toward more closed-inlet conditions, which may be related to competition and/or specific habitat supplies, for example, heavy metals such as vanadium, zinc, and molybdenum.

UUID:http://zoobank.org/12901a63-7cd5-4207-ac7a-0ce12649fcaf
Social support, functional outcome and quality of life among stroke survivors in an urban area
Authors: Butsing Nipaporn , Tipayamongkholgul Mathuros , Ratanakorn Disya , Suwannapong Nawarat , Bundhamcharoen Kanitta
Published: February 2019

Sophisticated medical technologies can prolong a stroke patient’s life but not always their quality of life (QoL) due to poor functional outcomes. Social support can theoretically assist a patient’s adaptation to life after stroke and improve their QoL, but existing findings are inconclusive. This inconclusiveness is especially found in large cities where family and social bonding can be scarce. We conducted a hospital-based, cross-sectional study among 358 stroke patients to identify the effects of social support and functional outcome on QoL and its domains. The study took place in Bangkok, Thailand between July and December 2016. Data were collected by personal interview using a structured questionnaire that included the Short-Form WHO Quality of Life Instrument (WHOQOL-BREF) and by review of medical records. A hierarchical linear regression method was used to analyze data. The mean age of stroke respondents was 66.0 years ( SD 13.5 years), and half were male. The mean total QoL score for patients was 68.6 ( SD 15.2). Hierarchical multiple regression analysis found emotional support significantly impacted QoL in every domain ( ps < .05) when all included variables were controlled for. To improve the quality of life among stroke survivors, health personnel and family members should provide not only physical assistance but also psychological support.
When Do Citizens Respond Politically to the Local Economy? Evidence from Registry Data on Local Housing Markets
Authors: LARSEN MARTIN VINÆS , HJORTH FREDERIK , DINESEN PETER THISTED , SØNDERSKOV KIM MANNEMAR
Published: February 2019

Recent studies of economic voting have focused on the role of the local economy, but with inconclusive results. We argue that while local economic conditions affect incumbent support on average, the importance of the local economy varies by citizens’ interactions with it. More recent and frequent encounters with aspects of the local economy make those aspects more salient and, in turn, feature more prominently in evaluations of the incumbent government. We label this process “context priming.” We provide evidence for these propositions by studying local housing markets. Linking granularly detailed data on housing prices from Danish public registries to both precinct-level election returns and an individual-level panel survey, we find that when individuals interact with the housing market, their support for the incumbent government is more responsive to changes in local housing prices. The study thus provides a framework for understanding when citizens respond politically to the local economy.
Diversity, Institutions, and Economic Outcomes: Post-WWII Displacement in Poland
Authors: CHARNYSH VOLHA
Published: February 2019

How does an increase in cultural diversity affect state–society interactions? Do institutional differences between heterogeneous and homogeneous communities influence economic activity? I argue that heterogeneity not only impedes informal cooperation but also increases demand for third-party enforcement provided by the state. Over time, the greater willingness of heterogeneous communities to engage with state institutions facilitates the accumulation of state capacity and, in common-interest states, promotes private economic activity. I test this argument using original data on post-WWII population transfers in Poland. I find that homogeneous migrant communities were initially more successful in providing local public goods through informal enforcement, while heterogeneous migrant communities relied on the state for the provision of public goods. Economically similar during state socialism, heterogeneous communities collected higher tax revenues and registered higher incomes and entrepreneurship rates following the transition to the market. These findings challenge the predominant view of diversity as harmful to economic development.
Centrorhynchus nahuelhuapensisn. sp. (Acanthocephala: Centrorhynchidae) from rufous-legged owl (Strix rufipesKing) in Patagonia
Authors: Steinauer M. , Flores V. , Rauque C.
Published: February 2019

Centrorynchus nahuelhuapensisn. sp. is described from the intestine ofStrix rufipes, the rufous-legged owl, in Patagonia, Argentina. This species is characterized by the presence of 31–33 hook rows with 16–17 hooks per row, distributed as follows: 5 true hooks, 4 transitional hooks with 4 alate processes, more evident in the first three, 7–8 spiniform hooks, and three cement glands. It differs from most members of the genus by having a filiform body, the arrangement and size of the hooks, the number of cement glands, and egg size. Part of the SSU and LSU genes were sequenced and compared to those in GenBank. Sequences are most similar to other species ofCentrorhynchus, supporting their placement within this genus. We present the first molecular study for a species ofCentrorhynchusfrom South America. Additionally, it is the second species of the genus described in Argentina, and the first species of a terrestrial acanthocephalan from a bird in Patagonia.
Adaptive Evolution in Rapid Assessments: A 25-Year Perspective
Authors: Corabian Paula , Guo Bing , Moga Carmen , Scott N. Ann
Published: February 2019

Objectives

This article retrospectively examines the evolution of rapid assessments (RAs) produced by the Health Technology Assessment (HTA) Program at the Institute of Health Economics over its 25-year relationship with a single requester, the Alberta Health Ministry (AHM).

Methods

The number, types, and methodological attributes of RAs produced over the past 25 years were reviewed. The reasons for developmental changes in RA processes and products over time were charted to document the push–pull tension between AHM needs and the HTA Program's drive to meet those needs while responding to changing methodological benchmarks.

Results

The review demonstrated the dynamic relationship required for HTA researchers to meet requester needs while adhering to good HTA practice. The longstanding symbiotic relationship between the HTA Program and the AHM initially led to increased diversity in RA types, followed by controlled extinction of the less fit (useful) “transition species.” Adaptations in RA methodology were mainly driven by changes in best practice standards, requester needs, the healthcare environment, and staff expertise and technology.

Conclusions

RAs are a useful component of HTA programs. To remain relevant and useful, RAs need to evolve according to need within the constraints of HTA best practice.
Differences in Chromatin Texture and Nuclear Fractal Dimension Between Hashimoto's and Lymphocytic Thyroiditis Lymphocytes
Authors: Todorović Jasna , Dinčić Marko , Nešović Ostojić Jelena , Zaletel Ivan , Lopičić Srdjan , Dundjerović Duško , Tatić Svetislav , Kovačević Sanjin , Paunović Ivan , Puškaš Nela , Marković Ljiljana
Published: February 2019

Previous evidence suggested that lymphocytic thyroiditis (LT) was a variant of Hashimoto's thyroiditis (HT), thus the aim of the current study is to quantify structural changes in histological specimens taken from HT and LT patients. A total of 600 images containing a single lymphocyte nucleus (300 nuclei per group) were obtained from 20 patients with HT and LT. In order to quantify changes in the nuclear architecture of investigated lymphocytes, the fractal dimension (FD) and some gray-level co-occurrence matrix texture parameters (angular second moment, inverse difference moment, contrast, entropy, and correlation) were calculated for each nucleus. A statistically significant difference in the FD of the “binary-outlined” nucleus and that of the corresponding “black-and-white” nucleus was detected between HT and LT lymphocyte nuclei. In addition, there was also a statistically significant difference in contrast and correlation between HT and LT lymphocyte nuclei. In conclusion, the results of this study suggested that there was a difference in structural complexity between investigated lymphocyte nuclei; additionally, LT lymphocytes possessed probably more complex texture and larger variations as well as more asymmetrical nuclei compared with HT lymphocytes. Accordingly, these findings indicate that LT is probably not a variant of HT; however, more complex studies are necessary to estimate differences between these types of thyroiditis.
Alternative measures of non-cognitive skills and their effect on retirement preparation and financial capability
Authors: Zamarro Gema
Published: February 2019

Individuals are increasingly asked to take responsibility for preparing for retirement and available financial products to do so are growing in sophistication. A better understanding of how non-cognitive skills influence financial capability and retirement preparation could help effective policy design. This area of research has been hampered by the struggle to find reliable measures of these skills. I argue that questionnaires themselves can be seen as performance tasks, such that measures of survey effort could lead to meaningful measures of non-cognitive skills. I exploit the fact that I observe respondents taking multiple survey modules covering different topics in different moments of time to build survey effort measures in a nationally representative internet panel. I use survey effort measures along with self-reports to study the role of non-cognitive skills on retirement preparation and financial capability. My results show that non-cognitive skills can have a significant role, beyond the role of cognitive ability.
Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis
Authors: K Giri Tusar , Newton David , Chaudhary Opal , Deych Elena , Napoli Nicola , Villareal Reina , Diemer Kathy , E Milligan Paul , F Gage Brian
Published: February 2019

Abstract. Low concentrations of serum vitamin K accompany high concentrations of undercarboxylated osteocalcin (ucOC) and osteoporotic fractures. Although vitamin K2 (MK-4) is approved as a therapeutic agent for the treatment of osteoporosis in some countries, the dose-response is unknown. The objective of this study was to assess the improvement in carboxylation of osteocalcin (OC) in response to escalating doses of MK-4 supplementation. A nine-week, open-labeled, prospective cohort study was conducted in 29 postmenopausal women who suffered hip or vertebral compression fractures. Participants took low-dose MK-4 (0.5 mg) for 3 weeks (until the second visit), then medium-dose MK-4 (5 mg) for 3 weeks (until the third visit), then high-dose MK-4 (45 mg) for 3 weeks. The mean ±  SD age of the participants was 69 ± 9 years. MK-4 dose (p < 0.0001), but neither age nor other relevant medications (e.g. bisphosphonates) correlated with improvement in %ucOC. As compared to baseline concentrations (geometric mean ±  SD) of 16.8 ± 2.4, 0.5 mg supplementation halved %ucOC to 8.7 ± 2.2 (p < 0.0001) and the 5-mg dose halved %ucOC again (to 3.9 ± 2.2; p = 0.0002 compared to 0.5-mg dose). However, compared to 5 mg/day, there was no additional benefit of 45 mg/day (%ucOC 4.6; p = NS vs. 5-mg dose). MK-4 supplementation resulted in borderline increases in γ-carboxylated osteocalcin (glaOC; p = 0.07). There were no major side effects of MK-4 supplementation. In postmenopausal women with osteoporotic fractures, supplementation with either 5 or 45 mg/day of MK-4 reduces ucOC to concentrations typical of healthy, pre-menopausal women.
Predictive Factors of Vitamin D Inadequacy among Older Adults in the United States
Authors: Lee Sunkyung , Lee Euni , Maneno Mary K. , Johnson Allan A. , Wutoh Anthony K.
Published: February 2019

Abstract. Optimal serum vitamin D levels are reported to be associated with many health benefits; however, few studies have determined predictive factors using national level data. An assessment of predictive factors for vitamin D inadequacy was conducted using National Health and Nutrition Examination Survey (NHANES) 2001–2006 data. Using the study sample including adults aged 40 years or more, data analysis was performed using the weighted multivariate logistic regression statistical procedure. The prevalence of vitamin D inadequacy (serum vitamin D <20 ng/ml) was 37.3%. Non-Hispanic Blacks were 6.4 times more likely to demonstrate vitamin D inadequacy compared to non-Hispanic Whites (ORadj=6.351; 95% CI 5.338, 7.555; p<0.0001). Also, female gender was a significant predictor of vitamin D inadequacy (ORadj=1.499; 95% CI 1.315, 1.708; p<0.0001) in multivariate models. Subjects who reported not taking vitamin D supplements in the past 30 days were more than twice as likely to be vitamin D inadequate compared with those who had taken dietary supplements containing vitamin D (ORadj=2.225; 95% CI 1.903, 2.601; p<0.0001). In conclusion, the strongest predictor of vitamin D inadequacy was non-Hispanic Black ethnicity. Other potential predictors included smoking, non-use of vitamin D supplements, abnormal BMI, collecting samples in winter, female gender, perception of own health condition as not excellent, lack of health care, and older age. More focused interventions targeting groups of United States residents with vitamin D inadequacy are needed.
Language Processing in Neurodegenerative Diseases
Authors: Jalvingh Fedor , Bastiaanse Roelien , Jonkers Roel
Published: February 2019

Abstract. Disorders of language and/or communicative abilities in neurodegenerative diseases are a common phenomenon. Over the past few decades, there has been a growing interest in language performance connected to these diseases. To date, studies in the field of language impairments in Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration (FTLD) have focused mainly on particular aspects of language processing in the isolated disease or on comparing certain language tasks in two neurodegenerative diseases. To enable a better understanding and comparison of the underlying linguistic deficits in all three disorders, this paper focuses on phonological, semantic, and grammatical processing in each of the disorders. A review of the literature on language processing deficits reveals that phonological, semantic, and grammatical processing is impaired in the early stages of AD, PD, and FTLD, and that the underlying deficits are sometimes linguistic in nature. Language disorders, however, may also reflect cognitive deficits, such as short-term verbal memory impairments, attention deficits, and reduced switching capacities, all of which have an impact on language processing.
What Are We Aiming For? Comparing Suicide by Firearm in Toronto With the Five Largest Metropolitan Areas in the United States
Authors: Sinyor Mark , Williams Marissa , Vincent Margaret , Schaffer Ayal
Published: February 2019

Abstract. Background: US suicide rates correlate with firearm availability. Little is known about variability in rates across countries. Aims: To observe the relationship between firearm/overall suicide rates in Toronto, Canada, and the five most populous US metropolitan areas. Method: Centers for Disease Control suicide rates by age and sex for New York, Los Angeles, Chicago, Dallas-Fort Worth, and Houston metropolitan areas were compared with equivalent data for Toronto (1999–2015). Results: Suicide rates by firearm, per 100,000 population, ranged from 0.45 in Toronto to 6.03 in Houston while rates by other methods ranged from 4.34 in Dallas-Fort Worth to 7.11 in Toronto. Overall rates of suicide ranged from 6.14 in New York to 10.45 in Houston. The two cities with the highest firearm suicide rates, Dallas-Fort Worth and Houston, also had much higher overall rates. Firearm suicides were most common in men over the age of 65 in all cities. Limitations: This study could not account for cultural differences between cities/countries. Conclusion: Much higher overall rates of suicide observed for Dallas-Fort Worth and Houston appear to be associated with high rates of suicide by firearm. Advocacy for means safety should target cities with high rates of firearm suicide and, in particular, elderly men.
The Geographic Heterogeneity of Suicide Rates in India by Religion, Caste, Tribe, and Other Backward Classes
Authors: Arya Vikas , Page Andrew , Dandona Rakhi , Vijayakumar Lakshmi , Mayer Peter , Armstrong Gregory
Published: February 2019

Abstract. Background: Caste, tribal, and religious associations, which are perhaps the most important aspects of personal and social lives in India, have been neglected in Indian suicide research. Aim: To investigate suicide rates in India by religion, caste, tribe, and other backward classes over the period 2014–2015. Method: This study acquired unpublished suicide data from the National Crime Records Bureau (NCRB) for 2014 and 2015 including caste, tribal, and religious associations of suicide cases. National and state-specific suicide rates (2014–2015) were then calculated for Hindus, Muslims, Christians, Sikhs, and other religious groups and for scheduled caste (SC), scheduled tribe (ST), and other backward classes (OBC). Results: The findings show higher suicide rates among Christian and other religious groups compared with Hindus and higher suicide rates among general populations compared with SC, ST, and OBC populations. However, the results varied among different regions highlighting the substantial geographical heterogeneity of suicide rates across India by caste and religion. Limitations: The suicide rates presented might be an underestimation of the true rates. Conclusion: Given the heterogeneity of minority/majority status by religion, caste, tribes, and OBC in different states, further investigation of the relationship between minority status and suicide is warranted.
Adaptation to Future Water Shortages in the United States Caused by Population Growth and Climate Change
Authors: Brown Thomas C. , Mahat Vinod , Ramirez Jorge A.
Published: February 2019

Population growth and climate change will combine to pose substantial challenges for water management in the United States. Projections of water supply and demand over the 21st century show that in the absence of further adaptation efforts, serious water shortages are likely in some regions. Continued improvements in water use efficiency are likely but will be insufficient to avoid future shortages. Some adaptation measures that have been effective in the past, most importantly large additions to reservoir storage, have little promise. Other major adaptations commonly used in the past, especially instream flow removals and groundwater mining, can substantially lower shortages but have serious external costs. If those costs are to be avoided, transfers from irrigated agriculture probably will be needed and could be substantial.
Atmospheric Waves and Their Possible Effect on the Thermal Structure of Saturn's Thermosphere
Authors: Müller‐Wodarg I. C. F. , Koskinen T. T. , Moore L. , Serigano J. , Yelle R. V. , Hörst S. , Waite J. H. , Mendillo M.
Published: February 2019

Atmospheric waves have been discovered for the first time in Saturn's neutral upper atmosphere (thermosphere). Waves may be generated from instabilities, convective storms or other atmospheric phenomena. The inferred wave amplitudes change little with height within the sampled region, raising the possibility of the waves being damped, which in turn may enhance the eddy friction within the thermosphere. Using our Saturn Thermosphere Ionosphere General Circulation Model, we explore the parameter space of how an enhanced Rayleigh drag in different latitude regimes would affect the global circulation pattern within the thermosphere and, in turn, its global thermal structure. We find that Rayleigh drag of sufficient magnitude at midlatitudes may reduce the otherwise dominant Coriolis forces and enhance equatorward winds to transport energy from poles toward the equator, raising the temperatures there to observed values. Without this Rayleigh drag, energy supplied into the polar upper atmosphere by magnetosphere‐atmosphere coupling processes remains trapped at high latitudes and causes low‐latitude thermosphere temperatures to remain well below the observed levels. Our simulations thus suggest that giant planet upper atmosphere global circulation models need to include additional Rayleigh drag in order to capture the effects of physical processes otherwise not resolved by the codes.
Evaluating Recent Updated Black Carbon Emissions and Revisiting the Direct Radiative Forcing in Arctic
Authors: Dong Xinyi , Zhu Qingzhao , Fu Joshua S. , Huang Kan , Tan Jiani , Tipton Matthew
Published: February 2019

There is significant uncertainty in the global inventory of black carbon (BC). Several recent studies have reported BC emission updates, including the Fire Emission Inventory‐northern Eurasia, anthropogenic emission in Russia, and global natural gas flaring. Compared with the inventory used by Intergovernmental Panel on Climate Change, these updates are only 10% higher on a global scale but are 3 times greater than previous estimations in Arctic (60–90°N). We applied GEOS‐Chem to examine these emission updates and evaluate their impacts on direct forcing. We found that Fire Emission Inventory‐northern Eurasia may be substantially overestimated, Russia shows no prominent influence on simulation, and natural gas flaring noticeably improves simulation performance in the Arctic. Model estimated direct forcing of BC is increased by 30% on the global scale and is 2 times higher in the Arctic through application of these emission updates. This study reveals the urgent need to improve the reliability of emission inventories in the high latitudes, especially over Eurasia.
Decreasing Trend in Black Carbon Aerosols Over the Indian Region
Authors: Manoj M. R. , Satheesh S. K. , Moorthy K. Krishna , Gogoi Mukunda M. , Babu S. Suresh
Published: February 2019

We examine long‐term trends in the near‐surface black carbon mass concentration, using multiyear primary data obtained from a dense network (ARFINET) of observatories over the Indian region. We report for the first time the statistically significant decreasing trend in black carbon mass concentration, based on primary data from this region, at an average rate of ~242 ± 53 ng · m−3 · year−1 during the period 2007–2016. This finding contrasts with the generally increasing trend in the columnar aerosol optical depth, reported earlier, and the steadily increasing trend in anthropogenic activities over this region. The roles of different possible mechanisms, including possible changes in the vertical redistribution of aerosols, are discussed. Over the period 2007–2015, a significant though weak, increasing trend is seen in the contribution from aerosols above 1 km to the columnar aerosol optical depth. These observations imply possible long‐term climate consequences.
How Global Warming Changes the Difficulty of Synoptic Weather Forecasting
Authors: Scher S. , Messori G.
Published: February 2019

Global warming projections point to a wide range of impacts on the climate system, including changes in storm track activity and more frequent and intense extreme weather events. Little is however known on whether and how global warming may affect the atmosphere's predictability and thus our ability to produce accurate weather forecasts. Here, we combine a state‐of‐the‐art climate and a state‐of‐the‐art ensemble weather prediction model to show that, in a business‐as‐usual 21st century setting, global warming could significantly change the predictability of the atmosphere, defined here via the expected error of weather predictions. Predictability of synoptic weather situations could significantly increase, especially in the Northern Hemisphere. This can be explained by a decrease in the meridional temperature gradient. Contrarily, summertime predictability of weekly rainfall sums might significantly decrease in most regions.
Groundwater Loss and Aquifer System Compaction in San Joaquin Valley During 2012–2015 Drought
Authors: Ojha Chandrakanta , Werth Susanna , Shirzaei Manoochehr
Published: February 2019

California's millennium drought of 2012–2015 severely impacted the Central Valley aquifer system and caused permanent loss of groundwater and aquifer storage capacity. To quantify these impacts within the southern San Joaquin Valley, we analyze various complementary measurements, including gravity changes from Gravity Recovery and Climate Experiment (GRACE) satellites; vertical land motion from Global Positioning System, interferometric synthetic aperture radar, and extensometer; and groundwater level records. The interferometric data set acquired by the Sentinel‐1 satellite only spans the period January 2015 and October 2017, while the other data sets span the entire drought period. Using GRACE observations, we find an average groundwater loss of 6.1 ± 2.3 km3/year as a lower bound estimate for the San Joaquin Valley, amounting to a total volume of 24.2 ± 9.3 km3 lost during the period October 2011 to September 2015. This is consistent with the total volume of 29.25 ± 8.7 km3, estimated using only Global Positioning System deformation data. Our results highlight the advantage of using vertical land motion data to evaluate groundwater loss and thus fill the gaps between GRACE and GRACE‐Follow‐On missions and complement their estimates. We further determine that 0.4–3.25% of the aquifer system storage capacity is permanently lost during this drought period. Comparing groundwater level and vertical land motion data following September 2015, we determine an equilibration time of 0.5–1.5 years for groundwater levels within aquitard and aquifer units, during which residual compaction of aquitard and land subsidence continues beyond the drought period. We suggest that such studies can advance the knowledge of evolving groundwater resources, enabling managers and decision makers to better assess water demand and supply during and in‐between drought periods.
The Unsolved Mystery of the Earth Blobs
Authors: Duncombe Jenessa
Published: February 2019

Researchers peering into Earth’s interior found two continent-sized structures that upend our picture of the mantle. What could their existence mean for us back on Earth’s surface?
Submesoscale Coherent Vortices in the Gulf Stream
Authors: Gula Jonathan , Blacic Tanya M. , Todd Robert E.
Published: February 2019

Seismic images and glider sections of the Gulf Stream front along the U.S. eastern seaboard capture deep, lens‐shaped submesoscale features. These features have radii of 5–20 km, thicknesses of 150–300 m, and are located at depths greater than 500 m. These are typical signatures of anticyclonic submesoscale coherent vortices. A submesoscale‐resolving realistic simulation, which reproduces submesoscale coherent vortices with the same characteristics, is used to analyze their generation mechanism. Submesoscale coherent vortices are primarily generated where the Gulf Stream meets the Charleston Bump, a deep topographic feature, due to the frictional effects and intense mixing in the wake of the topography. These submesoscale coherent vortices can transport waters from the Charleston Bump's thick bottom mixed layer over long distances and spread them within the subtropical gyre. Their net effect on heat and salt distribution remains to be quantified.
Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine
Authors: Sagebiel Adrian F. , Steinert Fenja , Lunemann Sebastian , Körner Christian , Schreurs Renée R. C. E. , Altfeld Marcus , Perez Daniel , Reinshagen Konrad , Bunders Madeleine J.
Published: February 2019

Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.
Monolithic lithium niobate photonic circuits for Kerr frequency comb generation and modulation
Authors: Wang Cheng , Zhang Mian , Yu Mengjie , Zhu Rongrong , Hu Han , Loncar Marko
Published: February 2019

Microresonator Kerr frequency combs could provide miniaturised solutions for a wide range of applications. Many of these applications however require further manipulation of the generated frequency comb signal using photonic elements with strong second-order nonlinearity (χ(2)). To date these functionalities have largely been implemented as discrete components due to material limitations, which comes at the expense of extra system complexity and increased optical losses. Here we demonstrate the generation, filtering and electro-optic modulation of a frequency comb on a single monolithic integrated chip, using a nanophotonic lithium-niobate platform that simultaneously possesses large electro-optic (χ(2)) and Kerr (χ(3)) nonlinearities, and low optical losses. We generate broadband Kerr frequency combs using a dispersion-engineered high-Q lithium-niobate microresonator, select a single comb line using an electrically programmable add-drop filter, and modulate the intensity of the selected line. Our results pave the way towards monolithic integrated frequency comb solutions for spectroscopy, data communication, ranging and quantum photonics.
Pattern of Altered Plasma Elemental Phosphorus, Calcium, Zinc, and Iron in Alzheimer’s Disease
Authors: Ashraf Azhaar , Stosnach Hagen , Parkes Harold G. , Hye Abdul , Powell John , So Po-Wah ,   for the AddNeuroMed consortium, Soinine Hilkka , Tsolaki Magda , Vellas Bruno , Lovestone Simon , Aarsland Dag , Kloszeweska Iwona , Mecocci Patrizia , Wahland Lars-Olaf
Published: February 2019

Metal/mineral dyshomeostasis has been implicated in the development of Alzheimer’s disease (AD). The aim of the study was to investigate the difference in absolute and percentage levels of plasma phosphorus, calcium, iron, zinc, copper, selenium in cognitively normal (CN) and AD subjects. Total reflection X-ray fluorescence (TXRF) spectroscopy was used to detect plasma metals/minerals in CN and AD subjects (n = 44 per group). TXRF detected significantly increased plasma levels of phosphorus (p = 1.33 × 10−12) and calcium (p = 0.025) in AD compared to CN subjects, with higher phosphorus/calcium (p = 2.55 × 10−14) ratio in the former. Percentage concentrations calculated for phosphorus, calcium, iron, zinc, copper, selenium by dividing the concentration of each element by the total concentration of these elements and multiplying by 100%, demonstrated phosphorus was higher in AD compared to CN subjects, while calcium, iron, zinc, copper and selenium were lower in AD subjects, with area under the curves as high as 0.937 (p = 6 × 10−5) computed from receiver operating curves. With exclusion of high levels of phosphorus and calcium from percentage calculations, iron levels remained low in AD whereas zinc was higher in AD, and copper and selenium levels were similar. We demonstrate altered distribution of elements in the plasma of AD subjects with high interdependencies between elemental levels and propose the potential of TXRF measurements for disease monitoring.
Author Correction: Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy
Authors: Frosina Guido , Ravetti Jean Louis , Corvò Renzo , Fella Mauro , Garrè Maria Luisa , Levrero Fabrizio , Marcello Diana , Marubbi Daniela , Morana Giovanni , Mussap Michele , Neumaier Carlo Emanuele , Profumo Aldo , Raso Alessandro , Rosa Francesca , Vagge Stefano , Vecchio Donatella , Verrico Antonio , Zona Gianluigi , Daga Antonio
Published: February 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Neurological sequel of chronic kidney disease: From diminished Acetylcholinesterase activity to mitochondrial dysfunctions, oxidative stress and inflammation in mice brain
Authors: Mazumder Muhammed Khairujjaman , Paul Rajib , Bhattacharya Pallab , Borah Anupom
Published: February 2019

With increasing prevalence, chronic kidney disease (CKD) has become a global health problem. Due to the retention of uremic toxins, electrolytes and water, and the resultant metabolic disturbances, CKD affects several organs, including the nervous system. Thus, CKD patients suffer from several neurological complications, including dementia, cognitive impairment, motor abnormalities, depression, and mood and sleep disturbances. However, the mechanisms underlying the neurological complications are least elucidated. We have recently reported a highly reproducible mice model of CKD induced by high adenine diet, which exhibited psychomotor behavioral abnormalities and blood-brain barrier disruption. In the present study, using the mice model, we have investigated psycho-motor and cognitive behaviour, and the neurochemical and histopathological alterations in brain relevant to the observed behavioural abnormalities. The results demonstrate global loss of Acetylcholinesterase activity, and decrease in neuronal arborisation and dendritic spine density in discrete brain regions, of the CKD mice. Oxidative stress, inflammation, and mitochondrial dysfunctions were found in specific brain regions of the mice, which have been regarded as the underlying causes of the observed neurochemical and histopathological alterations. Thus, the present study is of immense importance, and has therapeutic implications in the management of CKD-associated neurological complications.
Ectosymbionts alter spontaneous responses to the Earth’s magnetic field in a crustacean
Authors: Landler Lukas , Skelton James , Painter Michael S. , Youmans Paul W. , Muheim Rachel , Creed Robert P. , Brown Bryan L. , Phillips John B.
Published: February 2019

Magnetic sensing is used to structure every-day, non-migratory behaviours in many animals. We show that crayfish exhibit robust spontaneous magnetic alignment responses. These magnetic behaviours are altered by interactions with Branchiobdellidan worms, which are obligate ectosymbionts. Branchiobdellidan worms have previously been shown to have positive effects on host growth when present at moderate densities, and negative effects at relatively high densities. Here we show that crayfish with moderate densities of symbionts aligned bimodally along the magnetic northeast-southwest axis, similar to passive magnetic alignment responses observed across a range of stationary vertebrates. In contrast, crayfish with high symbiont densities failed to exhibit consistent alignment relative to the magnetic field. Crayfish without symbionts shifted exhibited quadramodal magnetic alignment and were more active. These behavioural changes suggest a change in the organization of spatial behaviour with increasing ectosymbiont densities. We propose that the increased activity and a switch to quadramodal magnetic alignment may be associated with the use of systematic search strategies. Such a strategy could increase contact-rates with conspecifics in order to replenish the beneficial ectosymbionts that only disperse between hosts during direct contact. Our results demonstrate that crayfish perceive and respond to magnetic fields, and that symbionts influence magnetically structured spatial behaviour of their hosts.