A familial case of cytomegalovirus infection in children
Authors:   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation, Markova K.V. , Skripchenko E.Yu. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Skripchenko N.V. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Rogozina N.V. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation, Karev V.E. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation, Marchenko N.V. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation, Gorelik E.Yu. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation, Vasilev V.V. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation, Markin I.V. ,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation,   Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency, Saint Petersburg, Russian Federation
Published: August 2024

The problem of cytomegalovirus infection (CMVI) in children is caused by its ubiquitous spread, polymorphism of clinical manifestations, which depends on the state of the human immune system. The article presents clinical cases of CMVI, demonstrating the possibility of developing a different variant of the course of acquired CMVI in children in the same family. The first case demonstrates a severe course of CMV infection in a patient 1 year 6 months old, hospitalized late in the course of the disease (day 8 of the disease). The peculiarity of this clinical case is the development of generalized form of CMVI in the child against the background of immunosuppression (monthly for 6 months. He had acute respiratory infections, which twice required antibiotic therapy, before hospitalization, a week-long contact with an aunt who had a clinically acute respiratory infection with herpetic elements on the lips) with organ damage (necrotizing hepatitis, myocarditis, sialoadenitis), which led to a fatal outcome, despite the full complex etiopathogenetic therapy. The second child from this family developed severe lesion of the brain substance with CMV, focal neurological symptoms (paresis of mimic muscles on the right side of the brain of central type, limb and trunk ataxia) and seizure syndrome. The importance of complex pathogenetic therapy with the use of cytoflavin in CMVinduced encephalitis was noted. Complex etiopathogenetic therapy allowed to achieve a favorable outcome of the disease with full recovery (cathamnestic observation was carried out for 3 years). Key words: cytomegalovirus, neuroinfections, encephalitis, hepatitis, sialoadenitis, cytoflavin, children