bluuebunny/crossref_metadata_2025 huggingface dataset:
Los maestri di strada, instrumentos de la actividad urbanís­tica en Roma durante el siglo XV
Authors: Montijano García Juan Mª
Published: September 2022

De entre las principales figuras administrativas de la urbanística romana del siglo XV destaca la de los maestri di strada. El papado tras su retorno a la ciudad utiliza esta vieja institución para sus distintas políticas edificatorias, modificando sus estatutos, y transfor­mando los cometidos específicos que a lo largo del siglo se extienden de la esfera higiénica a la de la proyectación de nuevos espacios públicos. Entre estas versiones destacan las de los pontífices Martín V, Nicolás V y Sixto IV.
Culminación del proyecto de ciudad burguesa en Jaén: el Teatro Cervantes de Manuel Rivera Vera
Authors: Hurley Isabel
Published: September 2022

Entre la segunda mitad del s. XIX y comienzos del s. XX, Jaén experimenta una serie de transformaciones similares a las de muchas otras capitales españolas, tanto en lo social como en lo económico, cultural, urbanismo, etc... En el núcleo de tales acontecimientos hallamos la voluntad renovadora de la nueva clase en alza, la rica burguesía, que ligará sus intereses al desarrollo de la ciudad, cuya imagen habrá de estar acorde al gran poder de sus nuevos dueños.
Razón e instinto en Picasso
Authors: Bravo Ruiz Natalia
Published: September 2022

La dicotomía entre categorías estéticas –razón e instinto, sensualismo y espiritualismo, clasicismo y barroco (también romanticismo y surrealismo), natura­leza y abstracción, cultura y barbarie, tradición y modernidad...– que podemos resumir, para entendernos, en la polaridad «clásico» y «anti-clásico» es, a menudo, tema de debate en el discurso crítico, filosófico o estético contemporáneo. Así, la concepción de dos principios contrarios ha sido expresada por Nietzsche, en lo apolíneo y lo dionisíaco; por Wolfflin, a partir del estilo lineal y el estilo pictórico; por d'Ors, en la dimensión sobretemporal de lo clásico y lo barroco; o bien, por Worringer, a través de los términos naturaleza y abstracción.
Tres esculturas de Luisa Roldán entre los bienes de doña María Díaz Bote (1716)
Authors: Barrio Moya José Luis
Published: September 2022

El 14 de noviembre de 1716 se firmaban en Madrid las capitulaciones matrimoniales entre Don Francisco Díaz Bote y Doña Josefa Guerrero, de una parte, y Don Isidro García Mateos de la otra, para que posteriormente éste último contrajera matrimonio con Doña María Díaz Bote, hija de los primeros, y viuda de Don Fran­cisco Pascual Coello
La polémica iglesia-mezquita de Benaque, en el término de Macharaviaya (Málaga)
Authors: Luque García Francisco Rafael , Íñiguez Carmen
Published: September 2022

La historiografía y las observaciones realizadas por las instituciones del patrimonio no aportan una solución definitiva al problema que plantea el título de este artículo. Para resolver la cuestión se realiza este estudio como primer paso para un proyecto de restauración, al que se pretende incorporar. Se realiza una revisión de la documenta­ción, un estudio del edificio y una hipótesis de su estado original, aportando una reconstrucción ideal del mismo
Las exposiciones de Bellas Artes en Málaga, 1843-1862
Authors: Palomo Díaz Francisco J.
Published: September 2022

El artículo historia el desarrollo de las exposiciones de Bellas Artes y otras diversas durante los años que median entre 1843, en que se celebró la primera, y la de1862, que se hizo coincidir con la visita de S.M. La Reina a Málaga. Se pone en evidencia la distancia entre una modernidad que se desea y una sociedad todavía con ciertos aspec­tos propios de Antiguo Régimen.
El peso de la historia en la arquitectura de los ingenieros del ejército. Algunos ejemplos en el ámbito norteafricano
Authors: Bravo Nieto Antonio
Published: September 2022

En la actualidad ya no son inusuales, en el panorama bibliográfico español, los trabajos que abordan con precisión el problema del estilo en la arquitectura que arran­ca a finales del siglo XIX y se desliza lentamente hasta la aparición del movimiento moderno.
Aparición de las pinturas murales en el interior de la igle­sia de Árchez (Málaga) durante su restauración
Authors: Luque García Francisco Rafael
Published: September 2022

En esta varia se pretende dejar testimonio de unas pinturas que apa­recieron en los muros del interior de la iglesia de Árchez. Estas pintu­ras representan diversos retablos y parte de un via crucis. Fueron descubiertas durante las obras de restauración de la iglesia que se llevaba a cabo en 1995.
El Modernismo en Teba. Un patrimonio de pintura mural desconocido
Authors: Asenjo Rubio Eduardo
Published: September 2022

La villa de Teba asiste a la incorporación de un nuevo elemento patrimonial: La arquitectura pictórica modernista. Jerarquización y uso de los espacios a través del color.
El esplendor de la memoria: el arte de la Iglesia de Málaga
Authors: Sánchez López Juan Antonio
Published: September 2022

Desde marzo a mayo de 1998, las Salas de Exposiciones del Palacio Episcopal se convertían en escenario de una cita cultural de primer orden, plasmada en el proyecto expositivo El Esplendor de la memoria.
Mechanics of Building Structural Materials Based on Lagrangian Mathematical Model Analysis
Authors: Zhang Yikun , Chen Hao , Zhu Jiankai , Mohamed Hamdy
Published: September 2022

This paper approximately analyzes the dynamic response mode of building materials under impact load according to the Lagrange equation. We use the redundant constraint force of the statically indeterminate structure to list its strain energy expression. At the same time, the paper introduces the Lagrange multiplier and combines the static equilibrium equation to obtain the internal force of the statically indeterminate structure. The calculation results show that the load duration and peak value are important factors determining structural members’ failure mode. This study lays the foundation for the research on the structural building material’s dynamic control and mechanism performance. At the same time, our research results also provide methods and ideas for the rigid body dynamics modeling of other structural redundant parallel mechanisms.
Nonlinear Differential Equation in Anti-aging Test of Polymer Nanomaterials
Authors: Liu Guangcheng
Published: September 2022

Rutile nano-TiO2 is a non-toxic and odorless inorganic UV shielding agent with excellent performance in polymer materials. This material absorbs part of the UV light energy through electronic transitions and releases it as heat or fluorescence. In this way, the molecular chain of the polymer material is prevented from being broken after absorbing high-energy ultraviolet light. So it has a certain antiaging effect. This article takes this material as the research object. We set up a molecular antiaging experiment for parametrically excited nonlinear differential equations. In this paper, the amplitude-frequency response of the system, the stability, and the bifurcation characteristics of the system are analyzed using the multiscale method. At the same time, we use numerical simulation to verify the theoretical analysis results. The research shows that the surface-treated nano-TiO2 has good dispersibility in polymer materials.
Effects of Different Cryoprotectants, Cryoprotectant Concentrations and Extenders for Short Term Cryopreservation of African Catfish Clarias gariepinus (Burchell, 1822) Milt
Authors: Mustapha Moshood Keke , Alade Aminat Ajoke
Published: September 2022

Aquaculture of Clarias gariepinus is on the increase in Africa. Among the challenges to its production is the scarcity and high cost of broodstocks and sacrifice of the male during induced breeding. Cryopreservation of the milt of the species is a solution to this challenge. However, cryopreservation success depends on right extender, cryoprotectant and concentration. Phosphate buffered solution (PBS) and freshwater ringer solution (extenders), Dimethyl sulphoxide (DMSO), glycerol and glucose (cryoprotectants) at 5% and 10% concentrations were used to investigate the best cryoprotectants, cryoprotectant concentrations and extenders for short term cryopreservation of Clarias gariepinus milt. Control using fresh milt was also set up. Fifteen each of matured male and female broodstocks of C. gariepinus, weighing between 1.1 – 2.0kg were used for the experiment. analysis of variance (ANOVA), followed by comparison of means using Duncan’s Multiple Range Test. Percentage data were calculated prior to analysis. All statistical analyses were performed using SPSS software (Version 16.0, 2005). Dimethyl sulphoxide + phosphate buffered solution (DP) had the highest fertilization rate of 65% and 78% for 5 and 10% cryoprotectant concentrations respectively. Lowest fertilization rate was in glucose + freshwater ringer solution (GF) with 5 and 10% concentration giving 5% and 8% fertilization. Fertilization in control was 88%. Hatching and survival followed fertilization trend with DP 10% > DP 5% > DF 10% > GLP 10% > DF 5% > GLP 5 % > GLF 10% > GLF 5% > GP 10% > GP 5% > GF 10% > GF 5%. Good quality sperm used, non-toxicity and high permeability of DMSO, osmolality effect of PBS on milt were some of the factors responsible for the success of the cryopreservation. 10% DMSO and PBS are the best cryoprotectant and extender for short term cryopreservation of African catfish milt for at least 5 days.
ANALISIS LAJU INFILTRASI TERHADAP BATUAN PENYUSUN KECAMATAN MAKASAR, KOTA JAKARTA TIMUR
Authors: Meze Muku Carollus Armando , Yuda Himmes Fitra , Amri M. Adimas
Published: September 2022

Infiltrasi dan jenis batuan menjadi hal yang cukup penting dalam sebuah parameter penentuan daerah resapan air. Jakarta merupakan kota dengan tingkat peralihan tata guna lahan cukup intens, sehingga daerah resapan air semakin berkurang dan tingginya tingkat pertumbuhan penduduk menyebabkan sering terjadinya bencana banjir saat musim hujan. Maka dari itu, perlu adanya rencana jangka panjang untuk mengelola tata ruang daerah resapan air di Jakarta sebagai salah satu langkah untuk menanggulangi bencana banjir dan menjadi cadangan air tanah di ibukota. Jenis batuan mengontrol pula sebagai kriteria daerah resapan. Pengambilan data uji nilai infiltrasi menggunakan data primer dengan pengukuran langsung di lapangan menggunakan Double Ring Infiltrometer, sedangkan jenis batuan penyusun dapat diketahui Peta Geologi Regional setempat yang merupakan hasil penelitian sebelumnya.
ANALISIS TIPE LONGSOR DAN KESTABILAN LERENG BERDASARKAN ORIENTASI DISKONTINUITAS PADA TEBING DANAU JAYAMIX
Authors: Montenova Diego , Adhitama Ramadhan , Sugiarto Eddy
Published: September 2022

Abstrak

Kontruksi di saat ini sudah terus menerus berkembang pesat seiring dengan kebutuhan masyarakat dimana kegiatan kegiatan kontruksi ini melibatkan perusahaan perusahaan tambang mulai membuka lahan tambang yang baru dan menghasilkan banyak jenis tambang yang baru, kegiatan pertambangan ini banyak menimbulkan dampak pada lahan terutama pada gangguan keseimbangan suatu tanah yang berakibatkan menjadi suatu longsor. Tujuan penelitian ini yaitu mengulas bagaimana dampak dari ketidakseimbangan lereng dengan menggunakan metode orientasi diskontinuitas atau faktor struktur geologi berupa diskontinuitas (kekar) yang dimana hasil penelitian ini akan memberikan ulasan berupa tipe longsoran dari tebing lereng Danau Jayamix ini dan dapat dinilai faktor keamanan dari kestabilan lereng Danau Jayamix ini.

 

Abstract

Construction at this time has been continuously growing rapidly in line with the needs of the community where these construction activities involve mining companies starting to open new mining areas and produce many new types of mines, these mining activities have a lot of impacts on the land, especially on disturbances in the balance of a land. which results in a landslide. The purpose of this study is to review how the impact of slope imbalance using the discontinuity orientation method or geological structure factors in the form of discontinuities (joints) where the results of this study will provide a review of the type of landslide from the cliffs of the slopes of Lake Jayamix and can be assessed the safety factor of the stability of the slopes of Lake Jayamix this.

 E-mail: Dmontenovaa@gmail.com

 Tel: +62-822-6800-7695
Equivalent Dynamic Model for Large Parabolic Cylindrical Deployable Mechanism
Authors: Yang Hui , Feng Jian , Wang Yan , Xiao Hong , Liu Yongbin
Published: September 2022

With the development of the space industry and the demand of future complex space missions, large space deployable antennas require high deployable ratio, high precision, and lightweight. A large parabolic cylindrical deployable (PCD) mechanism with a multilayer tape-spring (MLTS) hinge was proposed. The energy method was adopted to establish the equivalent dynamic model of the large PCD mechanism with MLTS hinges. The new problems encountered in the dynamic analysis of the new mechanism are solved. First, the nonlinear effects of the tape-spring hinges and cable in the PCD mechanism were considered. The relationship equations of strain and kinetic energy were derived. Then, the stiffness and mass matrices of the PCD mechanism were obtained. Based on Timoshenko beam theory, the modal analysis of the PCD mechanism in cantilever state was conducted. The finite element method was used to verify the correctness of the equivalent continuum model of the large PCD mechanism with MLTS hinges. The equivalent dynamic analytical method can be applied to the spatial large deployable mechanism.
O GÊNESIS, O LOGOS E OS PRÓLOGOS: LINGUAGEM CRIACIONISTA NO EVANGELHO E NA PRIMEIRA CARTA DE JOÃO
Authors: Aguiar Adenilton Tavares
Published: September 2022

O presente artigo discorre sobre a relação entre a narrativa da  criação registrada em Gênesis, o prólogo do evangelho de João e o prólogo de sua primeira carta. O texto está divido em três partes: o Gênesis e o Logos; o Logos e os Prólogos e Os Prólogos de João. Na primeira parte, discute-se a ligação entre as expressões “no princípio criou Deus” (Gn 1:1) e “no princípio era o verbo” (Jo 1:1); na segunda parte, analisa-se a maneira como algumas expressões de João 1 correspondem a expressões de Gênesis 1 (e.g., Gn 1:2-3; Jo 1:5; 1 Jo 1:5), evidenciando o interesse de João em mostrar que o poder exercido pelo Logos na Criação é o mesmo que restaura no homem a imagem e semelhança de Deus. Na última parte, são estabelecidas pontes de contato entre o prólogo da primeira carta e o prólogo do evangelho, a fi m de fortalecer a correspondência deste com a abertura do livro de Gênesis.
Squamous cell carcinoma in a patient with lichen planus of the oral mucosa
Authors: Kubanov Alexey A , Svishchenko Svetlana I. , Dontsova Elena V. , Mikhina Victoria A.
Published: September 2022

Lichen planus refers to dermatoses with frequent, often isolated, lesions of the oral mucosa. In the presence of rashes only on the oral mucosa, the diagnosis is difficult. At the same time, erosive-ulcerative forms of the disease present the greatest differential diagnostic difficulties. Cases that do not heal for a long time and are not amenable to treatment should be especially alert to the doctor due to the risk of malignancy.
The article describes a rare clinical case of squamous cell carcinoma of the oral mucosa in a 52-year-old patient with an erosive-ulcerative form of lichen planus of the oral cavity, characterized by a chronic long-term course, torpidity to therapy and simultaneous damage to the genital mucosa. The presented case emphasizes the importance of a thorough clinical examination, with a histological examination of the biopsy in order to monitor changes in the lesions.
The use of urea for skin barrier correction
Authors: Albanova Vera I. , Kalinina Olesya V. , Petrova Stanislava Yu.
Published: September 2022

The review summarizes information about the main causes and pathogenesis of xerosis cutis as one of the conditions indicating a violation of the epidermal barrier. Xerosis cutis is a clinical sign of a decrease in the amount and/or quality of lipids and/or hydrophilic substances in the stratum corneum of the epidermis. The modern approach to the treatment of dermatoses accompanied by violations of the epidermal barrier includes basic moisturizers. Urea not only moisturizes the skin. It is involved in the regulation of barrier function and antimicrobial protection. It is a low-molecular regulator of protein synthesis in keratinocytes, such as filaggrin, loricrin, involucrin and transglutaminase 1, cathelicidin, beta-defensin-2, water and urea carrier proteins into the cell, as well as proteins that promote the synthesis of intercellular matrix lipids. The main dermatotropic pharmacological effects of urea (hydration of the epidermis, strengthening of the barrier function of the skin, keratolytic effect, increased penetration of drugs into the skin) have been used in dermatological practice for many years. External agents with urea are used to treat skin diseases accompanied by dryness and excessive keratinization, to correct the deformation of nail plates of various genesis, to facilitate the local penetration of medicines. The use of topical UrocrEM5, UrocrEM10, Uroderm ointments containing 5%, 10% and 30% urea, respectively, is effective and safe.
Superconductivity in bismuth pyrochlore lattice compounds RbBi2 and CsBi2: the role of relativistic effects
Authors: Gutowska Sylwia , Wiendlocha Bartłomiej , Klimczuk Tomasz , Winiarski Michał
Published: September 2022

Superconducting properties of two bismuthide intermetallic compounds, RbBi2 and CsBi2, were studied by means of experimental measurements and ab initio calculations. We show that in both compounds the superconductivity emerges from the pyrochlore Bi lattice and its formation is heavily influenced by relativistic effects. Based on our analysis of the effect of spin-orbit coupling on the electron-phonon coupling we suggest a possible criterion for finding new superconducting materials by looking for structures featuring relativistically-stabilized hypervalent networks of heavy p-block elements.
Deoxygenative Suzuki-Miyaura Arylation of Tertiary Alcohols
Authors: Cook Adam , St. Onge Piers , Newman Stephen
Published: September 2022

The coupling of tertiary alcohols with boronic esters is described, providing a direct access to quaternary carbon scaffolds without needing to proceed by a highly activated intermediate such as an alkyl halide. A dual catalyst system is employed with both Ni(0) and Bi(III) components playing a critical role along with a mild chlorosilane reactant that enhances the yield by alcohol silylation. This method was found to tolerate diverse functional groups including chloro, nitro, olefin, ketone, ester and phenol moieties, while also being applicable to the derivatization of heterocyclic scaffolds. Mechanistic studies suggest the combination of Lewis acid catalyst and organosilane promote heterolytic cleavage of the substrate C–O bond by an SN1-like reaction pathway, providing a powerful strategy for derivatizing readily available alcohols.
Machine learning the Hohenberg-Kohn map to molecular excited states
Authors: Bai Yuanming , Vogt-Maranto Leslie , Tuckerman Mark , Glover William
Published: September 2022

The Hohenberg-Kohn theorem of density functional theory establishes the existence of a bijection between the ground-state electron density and the external potential of a many-body system. This guarantees a one-to-one map from the electron density to all observables of interest including electronic excited-state energies. Time-Dependent Density-Functional Theory (TDDFT) provides one framework to resolve this map; however, the approximations inherent in practical TDDFT calculations, together with their computational expense, motivate finding a cheaper, more direct map for electronic excitations. Here, we show that determining density and energy functionals via machine learning allows the equations of TDDFT to be bypassed. The framework we introduce is used to perform the first excited-state molecular dynamics simulations with a machine-learned functional on malonaldehyde and correctly capture the kinetics of its excited-state intramolecular proton transfer, allowing insight into how mechanical constraints can be used to control the proton transfer reaction in this molecule. This development opens the door to using machine-learned functionals for highly-efficient excited-state dynamics simulations.
A Vending Machine for Drug-like Molecules – Automated Synthesis of Virtual Screening Hits
Authors: MacMillan Angus E. , Wu Wilson W. X. , Nichols Paula L. , Wanner Benedikt M. , Bode Jeffrey
Published: September 2022

As a result of high false positive rates in virtual screening campaigns, prospective hits must be synthesised for validation. When done manually, this is a time consuming and laborious process. Large “on-demand’ virtual libraries ( > 7 x 1012 members), suitable for preparation using capsule-based automated synthesis and commercial building blocks, were evaluated to determine their structural novelty. One sub-library, constructed from iSnAP capsules, aldehydes and amines, contains unique scaffolds with drug-like physicochemical properties. Virtual screening hits from this iSnAP library were prepared in an automated fashion for evaluation against Aedes Aegypti and Phytophthora Infestans. In comparison to manual workflows, this approach provided a 10-fold improvement in user efficiency. A streamlined method of relative stereochemical assignment was also devised to augment the rapid synthesis. User efficiency was further improved to 100-fold by downscaling and parallelising capsule-based chemistry on 96-well plates equipped with filter bases. This work demonstrates that automated synthesis consoles can enable the rapid and reliable preparation of attractive virtual screening hits from large virtual libraries.
Heterogenized Molecular Rhodium Phosphine Catalyst within Metal-Organic Framework for Ethylene Hydroformylation
Authors: Samanta Partha , Solé-Daura Albert , Rajapaksha Remy , Wisser Florian M. , Meunier Frederic , Schuurman Yves , Sassoye Capucine , Mellot-Draznieks Caroline , Canivet Jerome
Published: September 2022

Molecularly-defined organometallic rhodium phosphine complexes were efficiently heterogenized within a MOF structure without affecting neither their molecular nature nor their catalytic behavior. Phosphine-functionalized MOF-808 served as solid ligand in a series of eight rhodium phosphine catalysts. These MOF-heterogenized molecular catalysts showed activity up to 2100 h-1 for ethylene hydroformylation towards pro-pionaldehyde as sole carbon-containing product. Combined experimental and computational methods applied to this unique MOF-based molecular system allowed unravelling structure and evolution of the Rh active species within the MOF under catalytic conditions, in line with molecular mechanisms at play during the hydroformylation reaction. The MOF-808 designed as a porous crystalline macroligand for well-defined molecular catalysts allows benefiting from molecular-scale understanding of interactions and mechanisms as well as from stabilization through site-isolation and recycling ability.
Roadmap to Pharmaceutically Relevant Reactivity Models Leveraging High-Throughput Experimentation
Authors: Xu Jessica , Kalyani Dipannita , Struble Thomas , Dreher Spencer , Krska Shane , Buchwald Stephen L. , Jensen Klavs F.
Published: September 2022

The merger of High-Throughput Experimentation (HTE) and data science presents an opportunity to both accelerate and inspire innovations in synthetic chemistry. Similarly, developments in machine learning (ML) have enabled the distillation of large and complex data sets into predictive models capable of generalizing patterns in the data. However, efforts to merge HTE with ML remain constrained by a few reported datasets with limited structural diversity and corresponding trained models that do not extrapolate well to substrates beyond the training set. Herein, we detail the first ML models for Pd-catalyzed C–N couplings using pharmaceutically relevant structurally diverse large data sets (~ 5000 unique products) generated using nanomole scale compatible chemistry. Careful consideration is given to both the diversity of the data set and accurate model predictions for substrates bearing features beyond those present in the training set. The structural diversity in the data set is enabled by leveraging the Merck & Co., Inc Building Block Collection with an initial focus on C–N coupling using secondary amines. The large dataset enables the systematic evaluation of model performance using five different data-splitting strategies. These five splits are carefully designed to evaluate the model’s ability to extrapolate beyond the substrates in the training set. The accuracy of classification models built with a lens toward application to medicinal chemistry campaigns exceeded the baseline precision-recall by 25-67% depending on the splitting strategy. These results would manifest as significant enrichment of successful C–N couplings using the hits recommended by the models. In addition, the accuracy of the best models for each of the five splits ranges between 70-87% suggesting excellent overall predictivity of the models even for completely unseen substrates.
The Arithmetic of Natural Language: Toward a typology of numeral systems
Authors:   University of California, Santa Barbara, USA, B. Comrie
Published: September 2022

Numeral systems in natural languages show astonishing variety, though with very strong unifying tendencies that are increasing as many indigenous numeral systems disappear through language contact and globalization. Most numeral systems make use of a base, typically 10, less commonly 20, followed by a wide range of other possibilities. Higher numerals are formed from primitive lower numerals by applying the processes of addition and multiplication, in many languages also exponentiation; sometimes, however, numerals are formed from a higher numeral, using subtraction or division. Numerous complexities and idiosyncrasies are discussed, as are numeral systems that fall outside this general characterization, such as restricted numeral systems with no internal arithmetic structure, and some New Guinea extended body-part counting systems.
CRYPTOGRAPHIC METHODS OF INFORMATION PROTECTION
Authors: Zolotareva Irina , Gorodinskaya Irina
Published: September 2022

The article discusses the methods of cryptographic protection of information. Methods of cryptographic protection of information are special methods of encryption, encoding or other transformation of information that make its contents inaccessible without presenting the cryptogram key and reverse transformation. Cryptographic protection is undoubtedly the most reliable method of protection, since the information itself is protected directly and there is no access to it.
Current Management of Pesticides Wastes in Some Cultivating Models in Vietnamese Mekong Delta
Authors: Nguyen Giao Thanh , Tran Thi Kim Hong
Published: September 2022

The study was carried out to evaluate the current status of use and management of waste from pesticides on some farming models in the Mekong Delta through interviews with 140 households cultivating triple-rice, Durian Ri6 and E-dor longan. The results of the study showed that 130 types of pesticides and 99 active ingredients were used on three farming models. The study also discovered that five banned active ingredients are still used in the triple-rice practice and four banned substances in the Durian Ri6 cultivation. The proportions of toxic groups (according to WHO’s classification) at levels II, III, IV were 33.3%, 29.3% and 37.4%, respectively. The triple-rice crop model used the most pesticides, but the frequency of spraying was only in the range of 6.48±1.72 to 7.33±1.82 times/crop. Meanwhile, the Durian Ri6 model, although using fewer pesticides, the frequency of spraying was very high (about 61.8±9.1 times/crop), 9 times higher than a rice crop. The cultivation of E-dor longan uses the least amount of pesticides as well as a very low frequency of spraying. The methods of handling pesticidal wastes are mainly burning, burying and these practices are not meeting the requirements for protecting health and the environment. The study provides important information for decision-making to choose a farming model and the accompanying environmental protection solutions to minimize the adverse effects of the use of pesticides.
Elasticity in the cloud related to database autonomies and scalability
Authors: Swapnil Raj , Anuj Kumar Raghav
Published: September 2022

Cloud computing has been a very popular paradigm for implementing online applications. Scalability, elasticity, cost of use, and large-scale economies are the main reasons for the effective and widespread acceptance of cloud computing. In this paper, we outline our work to inject the aforementioned "cloud capabilities" into a database system designed to support various applications deployed in the cloud: designing scalable databases using autonomies database and elasticity that enables lightweight resiliency using low-cost live database migrations and an intelligent and autonomous controller designed for system management without human intervention.
Cloud computing rising in the field of big data and artificial intelligence
Authors: Swapnil Raj
Published: September 2022

Cloud Computing is a strong, large-scale and complex Computing technology. It lessens the need to maintain an expensive, specialized computer hardware area, as well as expensive software and software. Cloud computing has shown a significant increase in data quality or the production of large amounts of data. Big data processing is a difficult and time-consuming operation that necessitates the use of a large computer system in order to ensure performance. Knowledge creation and analysis are two intertwined activities and this paper investigates the rise of Big Data and Artificial Intelligence (AI) in Cloud Computing research. As data storage and mining methods advance, the preservation of expanding data quantities is characterized by a change in the core of structured results. This shift is reflected in the evolution of structured results. However, one major barrier is that this rate of growth surpasses the ability of data gathering systems and cloud infrastructure platforms to be upgraded. Workloads are really heavy and it is possible that certain cloud computing disputes will be created, which will include the description, characteristics, and categorization of huge data. In addition, analysis problems based on data integrity, heterogeneity and protection.
Analytical model of an arched elastomeric shock absorber for use in simulation modeling of systems
Authors: Sinilshchikov V. B. , Kunavich S. A.
Published: September 2022

In this paper, a mathematical model for determining the longitudinal and transverse forces (reactions) of an arched elastomeric shock absorber when it is loaded along two axes (compression and transverse displacement of the supporting surfaces) is proposing. The reactions are presented as the sum of independent forces created by its two elastomeric walls. The webs are considered as beams that work in compression, bending and transverse shear, and can also lose stability. The model is phenomenological in nature. The structure of the model is such that in the case of pure compression of the shock absorber, the expression for the static axial reaction automatically satisfies the experimental static force characteristics of compression, which are given in the technical literature. The results of comparing the calculated data obtained by the developed model with the results of calculations in the Ansys Workbench 18.1 finite element analysis package are presented. In the region of deformations until the appearance of additional contact surfaces during buckling, a good agreement is observed. The developed analytical model of an arched elastomeric shock absorber can be used in calculations that require high speed (low computational complexity), in particular, for simulation modeling of systems in various software systems, such as Simulink.
Model-based development production of rocket and space systems in the context of products in aerospace universities
Authors: Kabanov А. А.
Published: September 2022

The work continues a series of publications devoted to the big topic of the formation of an end-to-end design and production-experimental environment in aerospace universities. This time, one of the components of this environment, which is currently least represented in educational institutions, is considered – the direction of model-oriented development of rocket and space industries. The substantiation of the relevance and necessity of studying the subject in modern conditions is given, and not only for specialists studying under the training programs for specializations in the production and technological profile but also for the design profile. Particular attention is paid to the parallel development of products in the context of their production systems and the development of production in the context of manufactured products. Groups of models used in the framework of model-based joint development of products and their production, as well as types of simulated production processes, are identified. The theoretical and methodological foundations of the developed approach to the development of educational disciplines of the direction, based on the experience of developing models of machine-building industries of rocket and space enterprises, are outlined. The structure and content of the disciplines are given. The experience of implementation in the educational process is analyzed, including on the example of practical tasks performed by students. The presented results can be adapted and used in other branches of mechanical engineering with a discrete type of production.
Caracterización de pacientes que se realizaron prueba de COVID-19, pertenecientes a una EAPB, Colombia
Authors: Méndez Rodríguez María Fernanda , Vargas Avellaneda Nidya
Published: September 2022

Introducción: la infección por SARS-CoV-2 ha representado un desafío para el sistema de salud y la humanidad. Se ha propagado mundialmente y Colombia no ha sido la excepción, al ser el cuarto país de Latinoamérica con más casos. Por esto es indispensable contar con toda la información disponible, lo que da lugar al objetivo de esta investigación, que es caracterizar la población afiliada a una EAPB que realiza pruebas diagnósticas por RT-PCR o antígeno para COVID-19 en Colombia durante el periodo de marzo de 2020 a febrero de 2021.
Metodología: estudio observacional de tipo transversal. La población estudiada son las personas afiliadas a una EAPB a quienes se les haya realizado prueba para el diagnóstico de COVID-19 en el periodo entre marzo 2020 y febrero 2021. Inicialmente, se realizó un análisis descriptivo de las variables. Para establecer posibles asociaciones, se implementaron test estadísticos paramétricos y no paramétricos de acuerdo con la distribución previamente evaluada. Todos los análisis estadísticos fueron llevados a cabo en el software R. Todos los test de significancia fueron a dos colas y se tomaron los valores p <0.05 como estadísticamente significativos.
Resultados: Fueron evaluados 638.493 registros de pruebas diagnósticas para SARS-CoV-2 entre marzo de 2020 y febrero de 2021. El 86,3% de las pruebas fueron de tipo RT-PCR, mientras que el 13,7% fueron test de antígeno. La positividad general encontrada en este periodo de tiempo fue del 26,8%, sin embargo, Caquetá, Vichada, Cauca, Cundinamarca, Norte de Santander, Boyacá y Bogotá presentaron índices de positividad más altos.
Conclusiones: caracterizar a la población afiliada a una EAPB que realiza pruebas diagnósticas para COVID-19 es una estrategia efectiva para la toma de decisiones en intervenciones de prevención, diagnóstico y tratamiento de esta patología y otras que se presenten en el futuro.
Aplicación del enfoque feminista a la realidad colombiana: un paso de la conciencia femenina a la conciencia colectiva
Authors: Motta León Claudia Patricia
Published: September 2022

Pareciese que hablar de feminismos y estudios de género está de moda en la academia, y es que basta con revisar los programas académicos de las universidades colombianas, especialmente, la información que corresponde a estudios de posgrado para advertir que el tema es tendencia y que tiene muchas posibilidades de ser aprovechado en investigaciones, ponencias, proyectos de extensión e innovación e, incluso, convocatorias internacionales.

Sin embargo, el análisis de los alcances y aplicabilidad de los conceptos género y feminismo en las dimensiones política, social, económica, educativa, sanitaria etc., y la incorporación de sus principios a la realidad de los individuos y comunidades, es una tarea que se encuentra pendiente todavía y cuya visibilización responde a un imperativo moral para aquellos que trabajamos en la formación de nuevos profesionales. Esta editorial es una crítica personal al feminismo, pero también un llamado a la reflexión y al activismo como camino para materializar los aportes de la teoría a la cotidianidad de las personas.
THE ROLE OF ANTIDEPRESSANTS IN THE CORRECTION OF CLINICAL, ENDOCRINE AND NEUROTRANSMITTER DISORDERS IN SUICIDAL BEHAVIOR: THE SEARCH FOR NEW THERAPEUTIC TRAJECTORIES
Authors: A.D. Artemyev , D.V. Baranov , S.V. Kiryukhina , V.G. Podsevatkin , D.A. Labunskiy , N.A. Kolmykova
Published: September 2022

Abstract. In order to study issues related to the drug correction of clinical, endocrine and neurotransmitter disorders in persons with suicidal behavior, the study of medical statistics of the neuropsychiatric service for the period from 2005 to 2022 was conducted. The paper highlights the ways to identify people with suicidal behavior, studied the prerequisites for its development. All studies were conducted in accordance with Article 11 of the Law of the Russian Federation of 02.07.1992 N 3185-1 (edition of 30.12.2021) "On psychiatric care and guarantees of the rights of citizens in its provision". The difference between true and false suicide has been determined. Pathogenetic mechanisms of formation of endocrine and neurotransmitter disorders, methods of treatment and prevention of suicidal mood are considered. Gender and age characteristics, as well as issues related to suicide in various countries of the world are analyzed. The cause-and-effect relationships that can lead to the act of suicide are highlighted. It was revealed that demographic mortality rates as a result of completed suicides were higher in the regions of the republic than in cities and amounted to 18.1- 24.5 per one hundred thousand population, the greatest suicide risk was observed at the age of 17 to 30 years. Many patients in this group either did not seek medical help from a psychiatrist at all due to stigmatization, or there was no compliance in treatment. These individuals independently stopped taking antidepressants after 1-2 weeks from the start of taking these drugs with the appearance of a slight initial improvement. The role of COVID-19 and its impact on the human psyche, as well as the role of the virus in the development of suicidal behavior, is touched upon. It was revealed that in the blood and cerebrospinal fluid in patients with suicidal behavior, there is an imbalance of cytokine status in the form of a decrease in the level of IL-10, an increase in the concentration of S-IL-2R, IL-1, IL-2, IL-6; a decrease in the activity and function of natural T cells. We have analyzed static data and made conclusions on this problem.
TRANSFECTION OF GFP PLASMIDS BY LIPOSOMAL CARRIERS IN B16 MELANOMA CELLS AND MELANOMA MODELS IN VIVO
Authors: E.Z. Lapkina , A.R. Esimbekova , N.V. Palkinа
Published: September 2022

Abstract. Background: Penetration of plasmid DNA into the nucleus by a passive process is ineffective due to the barrier effect of lipid membranes and diffusion barriers inside the cell. An effective gene delivery system should ensure binding to the target cell, penetration by endocytosis, protection from degradation and, ultimately, delivery of the expression plasmid to the nucleus. The distribution routes of transfected agents play a crucial role in achieving the targeted effect of drugs. In our experiment, plasmid DNA of the reporter protein GFP was used to study the distribution pathways. Aim: to evaluate the distribution of GFP reporter protein in B16 melanoma cells and distant organs of C57Bl6 mice as a method for determining the effectiveness of transfection of genetically engineered structures for the diagnosis and therapy of tumors in vivo. Materials and methods: An in vitro study was conducted on skin melanoma cell lines B16. Cells were transfected with a plasmid of the reporter protein GFP. In vivo, the study was conducted on mature female mice of the C57Bl/6 line, to which tumor cells were transplanted and GFP plasmid was intraperitoneally injected using commercial transfectants Lipofectamine 3.0 and Invivofectamine. The efficiency of transfection in organ and tumor cells was evaluated using the cell imaging station Floid. Results: A high survival rate of B16 melanoma cells was established and GFP+ B16 melanoma cells were obtained within 48 hours. We found that with intraperitoneal administration of a lipocomplex containing GFP plasmid, both with the use of Lipofectamine 3.0 transfectant and Invivofectamine, effective incorporation into liver and kidney parenchyma cells occurs. The penetration and retention of GFP reporter protein in liver, kidney and tumor node cells was revealed. Conclusion: The effectiveness of transfection of GFP plasmid into liver, kidney, and melanoma B16 tumor node cells of C57Bl6 mice has been proven. The data obtained indicate the prospects for the use of transfecting agents for penetration into target cells of genetically engineered structures for the purpose of diagnosis and therapy of tumors in vivo.
COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF CLASS III ANTIARRHYTHMIC DRUGS IN ELDERLY PATIENTS WITH PAROXYSMAL ATRIAL FIBRILLATION
Authors: T.A. Rybakova , V.V. Stolyarova , Kh.M. Bataev
Published: September 2022

Abstract. The article presents the results of the effectiveness of preventive antiarrhythmic monotherapy with sotahexal and cordarone based on heart rate variability and examination of patients at intervals of every 3 months for one year. The relevance of studying heart rate variability indicators is beyond doubt. The simplicity and non-invasiveness of this procedure dictates its increasing use. As a result of the study, the mechanism of occurrence of paroxysms of atrial fibrillation was shown both in patients with the existing paroxysmal form of atrial fibrillation, and in comparison, groups, where the debuts of this disease were recorded as a result of the study. It is known that with age there is an increase in diseases of the cardiovascular system, including atrial fibrillation. Elderly patients make up the bulk. Therefore, properly selected antiarrhythmic therapy based on heart rate variability indicators can help reduce morbidity in this group of patients. When studying the effectiveness of antiarrhythmic therapy on the example of representatives of the III class of antiarrhythmic drugs sotahexal and cordarone, it was found that the effectiveness of monotherapy with sotahexal and cordarone by the end of 1 year of the study was 74 and 71%, respectively. Indicators of heart rate variability in patients receiving sotahexal after 1 year did not significantly differ from each other, and at the initial stage of treatment, indicators characterizing the tone of the parasympathetic nervous system prevailed over the same indicators of patients receiving cordarone, over the tone differed from the initial ones in the downward direction. In patients receiving cordarone, a year later, there was a shift in the vegetative balance towards sympathicotonia compared with baseline indicators.
PROGNOSTIC VALUE OF CLINICAL AND LABORATORY MARKERS OF NERVOUS SYSTEM DAMAGE ASSOCIATED WITH PREGNANCY
Authors: G.K. Taitubaeva , I.A. Gribacheva , T.F. Popova , E.V. Petrova , L.A. Shchepankevich , O.A. Denisova
Published: September 2022

Abstract. Objective: To study, to systematize and to evaluate the prognostic significance of clinical and laboratory markers of nervous system damage associated with pregnancy with and without arterial hypertension (AH) in order to determine the main risk factors for the development of stroke. Materials and methods. Assessment of autonomic dysfunction, neuro-ophthalmological examination, additional research methods: laboratory and instrumental methods, including the study of gene polymorphism, CT, MRI Results. Based on the results of constructing a set of logistic regression models that generalize their results of a high probability detection algorithm, it is shown that in order to identify the final group of high risk of developing ischemic stroke in pregnant women, it is necessary to exclude patients without autonomic dysfunction before pregnancy, and also take into account the risks if they are detected in at least two stages. Factors such as the presence of cephalgic syndrome, autonomic dysfunction before pregnancy, contraception, concomitant pathology of more than 3 nosological units, hypoplasia of cerebral vessels, retinal angiopathy according to neuro-ophthalmological examination, elevated levels of fibrinogen and high activity of von Willebrand factor are common risk factors for the development of cerebrovascular accident ischemic type, regardless of the presence or absence of arterial hypertension.
DYNAMICS OF CYTOKINE PROFILE INDICATORS IN EXPERIMENTAL PERIODONTITIS
Authors: A.N. Zakhvatov , D.A. Khaidar , T.V. Tarasova , I.V. Begoulov , I.A. Zakharkin , S.A. Tambovtsev , A.Yu. Parshina
Published: September 2022

Abstract. The molecular level of physiological processes in the context of studying the pathogenesis of diseases is the basis for their diagnosis and treatment. Thus, the features of the pathogenesis of periodontitis are the direct participation of pro-inflammatory cytokines in the development of alterative inflammation. The study of the cytokine profile is relevant for both diagnostic and therapeutic purposes, since the dynamics of indicators of inflammatory mediators reflects the degree of activity and specificity of pathological reactions present in periodontitis. The purpose of the study Study of cytokine profile indicators in experimental periodontitis. Materials and methods. In an experiment on 50 white non-linear rats weighing 190-280 g, the model of experimental periodontitis proposed by Shkolnaya K.D., Atrushkevich V.G. was reproduced. (Patent RU No. 2625295 dated 07/12/2017). Assessment of the dynamics of the cytokine status of blood serum was carried out by the level of pro-inflammatory (IL-1β, TNF, IL-6, IL-17), anti-inflammatory (IL-4, IL-10) and regulatory (IL-2) cytokines using enzyme-linked immunosorbent assay using reagent kit "Bender MedSystems". Results. The study revealed the presence of an imbalance in the cytokine system, characterized by a violation of the physiological balance between pro-inflammatory and anti-inflammatory cytokines with a predominance of the former. Hyperproduction of cytokines persisted throughout the experiment with an increase in the above uncoupling by day 25, which indicates the formation of an immunoinflammatory process in the periodontium. Conclusion. The data obtained during the study confirm the presence of an imbalance of the cytokine network, which indicates the formation and progression of the inflammatory process of the periodontal complex, and also necessitates the introduction of drugs that inhibit the synthesis of pro-inflammatory mediators into complex therapy.