bluuebunny/crossref_metadata_2025 huggingface dataset:
Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages
Authors: Janssen William J , Danhorn Thomas , Harris Chelsea , Mould Kara J , Lee Frank Fang-Yao , Hedin Brenna R , D’Alessandro Angelo , Leach Sonia M , Alper Scott
Published: December 2019

Alveolar macrophages serve as central orchestrators of inflammatory responses in the lungs, both initiating their onset and promoting their resolution. However, the mechanisms that program macrophages for these dynamic responses are not fully understood. Over 95% of all mammalian genes undergo alternative pre-mRNA splicing. While alternative splicing has been shown to regulate inflammatory responses in macrophages in vitro, it has not been investigated on a genome-wide scale in vivo. Here we used RNAseq to investigate alternative pre-mRNA splicing in alveolar macrophages isolated from lipopolysaccharide (LPS)-treated mice during the peak of inflammation and during its resolution. We found that lung inflammation induced substantial alternative pre-mRNA splicing in alveolar macrophages. The number of changes in isoform usage was greatest at the peak of inflammation and involved multiple classes of alternative pre-mRNA splicing events. Comparative pathway analysis of inflammation-induced changes in alternative pre-mRNA splicing and differential gene expression revealed overlap of pathways enriched for immune responses such as chemokine signaling and cellular metabolism. Moreover, alternative pre-mRNA splicing of genes in metabolic pathways differed in tissue resident vs. recruited (blood monocyte-derived) alveolar macrophages and corresponded to changes in core metabolism, including a switch to Warburg-like metabolism in recruited macrophages with increased glycolysis and decreased flux through the tricarboxylic acid cycle.
WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data
Authors: Holdorf Amy D , Higgins Daniel P , Hart Anne C , Boag Peter R , Pazour Gregory J , Walhout Albertha J M , Walker Amy K
Published: December 2019

The emergence of large gene expression datasets has revealed the need for improved tools to identify enriched gene categories and visualize enrichment patterns. While gene ontogeny (GO) provides a valuable tool for gene set enrichment analysis, it has several limitations. First, it is difficult to graph multiple GO analyses for comparison. Second, genes from some model systems are not well represented. For example, ∼30% of Caenorhabditis elegans genes are missing from the analysis in commonly used databases. To allow categorization and visualization of enriched C. elegans gene sets in different types of genome-scale data, we developed WormCat, a web-based tool that uses a near-complete annotation of the C. elegans genome to identify coexpressed gene sets and scaled heat map for enrichment visualization. We tested the performance of WormCat using a variety of published transcriptomic datasets, and show that it reproduces major categories identified by GO. Importantly, we also found previously unidentified categories that are informative for interpreting phenotypes or predicting biological function. For example, we analyzed published RNA-seq data from C. elegans treated with combinations of lifespan-extending drugs, where one combination paradoxically shortened lifespan. Using WormCat, we identified sterol metabolism as a category that was not enriched in the single or double combinations, but emerged in a triple combination along with the lifespan shortening. Thus, WormCat identified a gene set with potential. phenotypic relevance not found with previous GO analysis. In conclusion, WormCat provides a powerful tool for the analysis and visualization of gene set enrichment in different types of C. elegans datasets.
Binding and Regulation of Transcription by Yeast Ste12 Variants To Drive Mating and Invasion Phenotypes
Authors: Zhou Wei , Dorrity Michael W , Bubb Kerry L , Queitsch Christine , Fields Stanley
Published: December 2019

Here, Zhou et al. took advantage of Saccharomyces cerevisiae and its well-characterized mating and invasion pathways to explain how transcription factor variants alter motif recognition and gene expression, and ultimately, organismal phenotypes...

Amino acid substitutions are commonly found in human transcription factors, yet the functional consequences of much of this variation remain unknown, even in well-characterized DNA-binding domains. Here, we examine how six single-amino acid variants in the DNA-binding domain of Ste12—a yeast transcription factor regulating mating and invasion—alter Ste12 genome binding, motif recognition, and gene expression to yield markedly different phenotypes. Using a combination of the “calling-card” method, RNA sequencing, and HT-SELEX (high throughput systematic evolution of ligands by exponential enrichment), we find that variants with dissimilar binding and expression profiles can converge onto similar cellular behaviors. Mating-defective variants led to decreased expression of distinct subsets of genes necessary for mating. Hyper-invasive variants also decreased expression of subsets of genes involved in mating, but increased the expression of other subsets of genes associated with the cellular response to osmotic stress. While single-amino acid changes in the coding region of this transcription factor result in complex regulatory reconfiguration, the major phenotypic consequences for the cell appear to depend on changes in the expression of a small number of genes with related functions.
Análisis SEM para el gasto turístico en un país emergente
Authors: Guillén Uyen Jorge
Published: December 2019

El siguiente estudio intenta examinar la relación entre las preferencias del consumidor y el gasto en un marco de Modelo de Ecuación Estructural (SEM, por sus siglas en inglés). Usamos datos de una encuesta aplicada en un país emergente como Perú. Hubo 6 772 encuestados clasificados por sexo, país de residencia, nivel educativo y edad. Los encuestados extranjeros especificaron sus motivos y preferencias para viajar, así como el dinero gastado. La técnica SEM permite encontrar una relación entre las últimas variables. Esta evaluación es relevante para los responsables de la política turística, ya que ayudará a encontrar los principales factores de gasto de los visitantes extranjeros dentro de un país emergente. Nuestro estudio permitió identificar los motivos para visitar: ocio, negocios y educación, y otros, como principales impulsores del gasto turístico.
Influence of Altitude and Environmental Temperature on Muscle Functional and Mechanical Activation After 30' Time Trial Run
Authors: Rojas-Valverde Daniel , Ugalde Ramírez Jose Alexis , Sánchez-Ureña Braulio , Gutiérrez-Vargas Randall
Published: December 2019

The purpose of this study was to explore the influence of altitude and environmental temperature on muscle mechanical and functional activation after 30' Time Trial run (30' TT). Twenty physical active males (Age= 20.4 ±3.21 years, VO2max= 47.2 ±5.2 ml/kg/min) performed a 30' TT in three different conditions of altitude and temperature: Control Condition [CC] (1137 m.a.s.l. at 26 ±1.5°C), Heat-Low Condition [HLC] (3 m.a.s.l. at 30.5 ±0.6°C), and Cool-High Condition [CHC] (2369 m.a.s.l. at 14.2 ±0.6°C). Tensiomyography (TMG), Countermovement Jump (CMJ), and Delayed Onset Muscle Soreness (DOMS) were measured pre and post running. During the 30' TT, distance, speed, heart rate (HR), rate of perceived exertion (RPE), and thermal index (WBGT) were measured. Results show a significant decrease in body weight and a significant increase in DOMS and jump height in CMJ after running in each condition. TMG responses increased maximum radial muscle displacement (Dm) and decreased muscle contraction time (Tc) both rectus and biceps femoris muscles after running. During the 30' TT, the results did not show a significant difference in RPE, HR, distance, and speed among conditions. In conclusion, altitude and temperature seem not to significantly affect the mechanical and functional responses 30' TT, despite the tendency of HLC to decrease both activation and performance.
Capacitación en conservación y manejo de humedales en el neotrópico
Authors: Tabilo Elier
Published: December 2019

No disponible/Not available
Funcionamiento de ecosistemas de agua dulce: clave para la gestión sostenible del recurso hídrico
Authors: Bergkamp Ger , Acreman Mike , Córdoba Rocío , Lahmann Enrique
Published: December 2019

No disponible/Not available
Lapa verde, víctima del manejo forestal insostenible
Authors: Chassot Olivier , Monge Guiselle , Powell George , Palminteri Suzanne , Alemán Ulises , Wright Pamela , Adamek Krista
Published: December 2019

No disponible/Not available
Participación social y organización en la rehabilitación de la Cuencia del Río Segundo
Authors: Charpentier Claudia
Published: December 2019

No disponible/Not available
Ecoturismo en América Latina. Actualidad y derroteros
Authors: Budowski Gerardo
Published: December 2019

No disponible/Not available
Innovaciones campesinas en el marco de la forestería comunitaria en Centroamérica
Authors: Valverde Jaime , Ardón Mario , Colindres Ibis , Elías Silvel , Rivas Abelardo , Zappacosta Mario
Published: December 2019

No disponible/Not available
Gestión integrada del agua en Costa Rica. Hacia una nueva ley
Authors: Méndez Huberth , López Raúl , Mora Portuguez Jorge
Published: December 2019

No disponible/Not available
Insensato explotar energía en áreas protegidas
Authors: Portilla Rolando
Published: December 2019

No disponible/Not available
Aplicación de la propuesta para fortalecer la vivencia de los valores de solidaridad y empatía con niños y niñas de 4 a 5 años, de una institución privada de Heredia, por medio de talleres lúdicos-creativos
Authors: Vargas Mora Mónika , Basten Michelle
Published: December 2019

Recibido 29 de noviembre de 2012 •  Corregido 01 de mayo de 2013 • Aceptado 19 de junio de 2013El objetivo fue analizar, en qué forma, el desarrollo de talleres lúdico-creativos fortalecen la vivencia de los valores de solidaridad y empatía con niños y niñas de 4 a 5 años que asisten a una institución privada en Heredia. Esta investigación fue de tipo cualitativa y se desarrolló en tres etapas. Una etapa diagnóstica para describir los conocimientos previos de las personas participantes con dichos valores, la cual se llevó a cabo por medio de entrevistas y observaciones no participantes. La segunda etapa consistió en formular y aplicar talleres lúdico-creativos que fortalecieran estos valores en el estudiantado. La última etapa fue un análisis comparativo entre la información recolectada inicialmente y los datos recopilados después de implementada la propuesta, para así verificar si la aplicación de dichos talleres influye en la vivencia de los valores de empatía y solidaridad en la niñez participante. Una de las principales conclusiones consiste en que al poder compartir y trabajar con los estudiantes y las estudiantes con esta metodología, se logró implementar una conciencia respecto a los sentimientos de las personas que los rodean, así como mejorar la convivencia de los niños y niñas con los demás.
Un camino hacia el cambio en el aprendizaje: La expedición como recurso pedagógico en el ámbito universitario
Authors: Vásquez Salazar Érika
Published: December 2019

Recibido 30 de abril de 2013 • Corregido 5 de agosto de 2013 • Aceptado 11 de setiembre de 2013Este artículo representa la sistematización de diferentes experiencias con expediciones pedagógicas en educación superior, las cuales se desarrollaron entre los años 2005 y 2012 en la División de Educación Básica (DEB) en la Universidad Nacional. La expedición fue utilizada como un recurso pedagógico para el desarrollo de actitudes y aptitudes con estudiantes de varias carreras de educación. La autora señala la expedición pedagógica como una de las posibles estrategias que se pueden utilizar para promover la innovación en la educación superior y lograr un cambio positivo en el abordaje de los procesos de enseñanza y aprendizaje. Se presenta la expedición como una herramienta que le brinda al estudiantado una oportunidad que le permite concretar su plan de estudios de una forma más significativa, participativamente y en contacto con la realidad educativa; además de que le humaniza y le ayuda a reinventarse como persona y como futuro docente.
Elevated Colonic Mucin Expression Correlates with Extended Time to Surgery for Ulcerative Colitis Patients
Authors: Eshelman Melanie A , Jeganathan N Arjun , Schieffer Kathleen M , Kline Bryan P , Mendenhall Megan , Deiling Sue , Harris Leonard , Koltun Walter A , Yochum Gregory S
Published: December 2019

Background and Aims: Both genetic and environmental factors contribute to the development and persistence of ulcerative colitis (UC). As supported by differential responses to therapy, multiple subclasses of disease likely comprise UC. We reasoned that profiling the colonic transcriptomes may offer one approach to molecular subtype UC.

Methods: We conducted RNA-sequencing (RNA-seq) on full-thickness colonic tissues from 26 UC patients undergoing colectomy. Hierarchal clustering from transcriptomic data identified disease subsets. Subsets were characterized using differential gene expression analysis, cell type deconvolution, and network analysis.

Results: We identified two UC subsets that were distinguished by 957 differentially expressed genes. Cluster 1 was enriched in genes associated with intestinal epithelial cell (IEC) differentiation, while cluster 2 was enriched in genes associated with epithelial-to-mesenchymal transition (EMT) and inflammatory responses. Cluster 1 was associated with an extended time from diagnosis to colectomy [hazard ratio = 0.45 (95% CI: 0.14-0.88); p=0.03]. Of cluster 1 genes, elevated MUC5B, MUC4, and MUC2 expression displayed the strongest correlation with increased time to surgery [hazard ratio = 0.37 (95% CI: 0.11-0.61); p=0.0044].

Conclusions: Our transcriptome analysis indicates that UC can be sub-classified into at least two molecular signatures. We found that elevated mucin gene expression correlated with prolonged time to colectomy following diagnosis. This work identified MUC5B, MUC4, and MUC2 as potential prognostic indicators of disease severity, as reflected in time to surgery after diagnosis.
Analisis Perbandingan Efisiensi Bank Umum Konvensional dan Bank Umum Syariah di Indonesia
Authors: Rahmawati Azizah Kartika , Sari S. R. Kartika , Hermawan Herry
Published: December 2019

The purpose of this study was to determine the level of efficiency between conventional commercial banks and Islamic commercial banks. The sampling technique used in this study was purposive sampling by taking state-owned banks and Islamic commercial banks with the highest assets. Efficiency measurement in this study uses the Data Envelopment Analysis (DEA) method. The results of this study indicate that there are differences in efficiency between conventional commercial banks and Islamic commercial banks. Overall, each bank has an efficiency level of 93.67% (conventional commercial banks) and 99.99% (Islamic commercial banks). These results indicate that Islamic commercial banks are more efficient than conventional commercial banks.
Lesion Preparation with Orbital Atherectomy
Authors: Shlofmitz Evan , Jeremias Allen , Shlofmitz Richard , Ali Ziad A
Published: December 2019

Despite significant improvements in stent design, severe coronary calcification continues to impede adequate stent expansion and is associated with worse clinical outcomes. Angiography is limited in its ability to detect and comprehensively characterise calcified plaque. Intravascular imaging provides information on lesion morphology guiding appropriate treatment strategies. Orbital atherectomy allows for lesion preparation of severely calcified plaque prior to stent implantation. Utilising a unique mechanism of action incorporating centrifugal forces, a standard 1.25 mm eccentrically mounted and diamond-coated burr orbits bi-directionally to ablate calcified plaque. Lesion preparation with orbital atherectomy allows for modification of calcified plaque to facilitate stent expansion.
Contemporary Management of Out-of-hospital Cardiac Arrest in the Cardiac Catheterisation Laboratory: Current Status and Future Directions
Authors: Pareek Nilesh , Kordis Peter , Webb Ian , Noc Marko , MacCarthy Philip , Byrne Jonathan
Published: December 2019

Out-of-hospital cardiac arrest (OHCA) is an important cause of mortality and morbidity in developed countries and remains an important public health burden. A primary cardiac aetiology is common in OHCA patients, and so patients are increasingly brought to specialist cardiac centres for consideration of coronary angiography, percutaneous coronary intervention and mechanical circulatory support. This article focuses on the management of OHCA in the cardiac catheterisation laboratory. In particular, it addresses conveyance of the OHCA patient direct to a specialist centre, the role of targeted temperature management, pharmacological considerations, provision of early coronary angiography and mechanical circulatory support.
SIRTÇANTALILARIN KAÇIŞ DENEYİMİ: AKIŞ KURAMI YAKLAŞIMI
Authors: İŞÇİ Ceren , GÜZEL Berrin
Published: December 2019

Sırtçantalı hareket, turizm endüstrisi açısından önemli
ve sürekli yükselen bir pazar olarak görülmektedir. Sırtçantalıların kitle
turistinden farklı olarak, seyahatleri sırasında olağanüstü, yoğun bir deneyim
olan akışı yaşadıkları, kendilerini mekânlara kaptırdıkları, zaman kavramını
kaybettikleri, yüksek odaklanma, eğlence, merak hissi duydukları bilinmektedir.
İlgili alan yazında, akış deneyiminin aynı zamanda önemli bir sırtçantalı motivasyonu
olarak görülen kaçış deneyimine etkileri kuramsal olarak tartışılmış olsa da
ölçülmemiştir. Mevcut çalışma, akış ve kaçış arasındaki bu ilişkiyi ölçmeyi
amaçlamıştır. Araştırmada anket tekniğinden yararlanılmıştır. Anketler
sırtçantalıların üye oldukları çeşitli çevrimiçi platformlardan toplanmıştır.
Veri toplama süreci sonunda analiz edilebilir 231 anket formu elde edilmiştir.
Akış ve kaçış deneyimlerini merkezine alan teori, yapısal eşitlik modeli ile
test edilmiş, modelin iyi uyum endeksleri ürettiği ortaya çıkmıştır. Araştırma
sonucunda eğlence/merak, odaklanılmış dikkat, zamanın kaybolması olmak üzere üç
alt faktörden oluşan akışın, kaçış deneyimini pozitif yönde etkilediği
saptanmıştır.
Holistic analysis of the effect on electricity cost in South Africa’s platinum mines when varying shift schedules according to time-of-use tariffs
Authors: Shaw William George , Mathews Marc , Marais Johan
Published: December 2019

In the past the cost of electricity was not a significant concern and was not common practice for mining companies to consider peak time-of-use (TOU) tariffs for their shift schedules. It has become more prevalent, as TOU tariffs continue increasing, to consider energy saving important. A study was carried out to analyse the mining operation of a South African deep-level platinum mine in respect of integrated load management, shift changes and TOU schedules. This was achieved by thoroughly analysing energy consumers, mine operational schedules and their interconnectedness. A specific mining system was analysed as a case study and a maximum savings scenario was determined, using the methodology formulated. The maximum savings scenario schedule change resulted in a 1.3% cost reduction. System improvements had an additional potential reduction effect of 8.4%, which was primarily the result of a reduction in compressors’ power consumption. The implications of the proposed schedule adjustments necessitated a realistic scenario. The realistic scenario had an effective financial reduction of 0.7%. The realistic schedule change, however, opened the door for large system operational improvements, which could increase the reduction potential by 7.6%. The study methods described illustrate the potential implications of integrated load management and operational schedule optimisation on the power demand and cost savings in the mining industry, specifically focusing on deep-level platinum mines.
Compound fault detection in gearbox based on time synchronous resample and adaptive variational mode decomposition
Authors: Zhang Xin , Zhao Jianmin
Published: December 2019

Compound fault detection of gearboxes is an ambitious matter considering its interconnection and complication. An innovative
means for compound fault detection based on time synchronous resample (TSR) and adaptive variational mode decomposition
(AVMD) is put forward in this work. TSR used in the method can enhance fault signals of synchronous shaft gears by eliminating
signal components independent of synchronous shaft. Therefore, the TSR is used to separate the synchronous shaft signal corresponding to the gear fault from the raw compound fault signal. Then a series of mode components are obtained by decomposing
the synchronous shaft signals of all faults by AVMD. The variational mode decomposition (VMD) can overcome the mode aliasing problem of empirical mode decomposition (EMD), but the decomposition effect of VMD is affected by its parameter setting.
Thus, the paper proposes an AVMD algorithm based on whale optimization algorithm (WOA). In the AVMD, the WOA is used to
optimizes the parameters of the VMD. After AVMD decomposition, the correlated kurtosis of the mode components obtained by
AVMD decomposition is calculated. Then the mode components with the maximum correlated kurtosis are selected to carry out
envelope analysis. Finally, the compound fault feature can be found from the envelope spectrum to get the diagnosis results. In
order to test the validity of the proposed method, a compound fault experiment is implemented in a gearbox. Through the analysis
of the experimental data, it is proved that the method shows a good performance in the compound fault detection of gearbox
Model of Hybrid Satellite-Inertial Navigation System with Partial Structure
Authors: Devyatisilny A. S. , Shurygin A. V.
Published: December 2019

A mathematical model of a hybrid navigation system (GNS) consisting of a three-component block of linear newtonometers (accelerometers) physically simulating a vector-based measurer of non-gravitational nature forces and on-board GLONASS receivers that positioning a moving object in an ellipsoidal coordinate system is presented and investigated. The absence of a gyroscopic angular velocity sensors unit, traditional for the classical schemes of the inertial navigation method, and the presence of no more than two onboard satellite positioning devices (receivers) make it possible to characterize the considered GNS as a partial structure system. As a basic element of a mathematical model for estimating linear and angular parameters of an object’s motion, the developed procedure of multiple numerical differentiation of temporal data acquired from on-board satellite receivers, which functions stably irrespective of the magnitude of the discretization step of the problem in time, was used. The developed GNS makes it possible to qualitatively evaluate both the trajectory parameters (location, velocity, acceleration and forces causing the trajectory) as well as the parameters of the spatial orientation of the object (Euler-Krylov angles and its derivatives) with a two-positioning technique. The results of the computational experiment are given. The field of application of the research results is numerical-analytical planning of trajectories, determination of motion parameters and control of moving objects for various purposes and basing.
IMAGE OF THE UKRAINIAN EMIGRANT IN THE SMALL PROSE OF VOLODYMYR BIRCHAK
Authors: Novak Snizhana
Published: December 2019

The article analyzes the peculiarities of the formation of V. Birchak a collective image of a nationally conscious Ukrainian-emigrant, endowed with many virtues and disadvantages, forced to overcome the challenges of the emigrant fate. Considered the writer’s understanding of the events of the life of Ukrainian emigration after the defeat of the national liberation struggles of 1918 – 1920, in which the prose writer also participated directly, because of which he also lived and worked on emigration.

Volodymyr Birchak (1881– 1952) is one of the founders of the Lviv Modernist literary group Young Muse (1906 – 1014), a Galician, a writer-pedagogue who directly participated in the national liberation struggle of Ukrainians from 1918 to 1920, and after the defeat was forced was to emigrate to Transcarpathia, which then belonged to Czechoslovakia. The writer’s close and understandable were the experiences and wandering of Ukrainian emigrants who sought salvation from the Moscow invasion beyond their native land without livelihood, without the possibility of obtaining citizenship, finding a job, adapting to life without the glow of enemy bullets.

The article deals with the collection of stories “The Golden Violin” (1937) and the story “The Emigrant” (1941), which was not included in the collections. The composite-organizing components of many of these stories are trials that fell to the fate of the heroes. The motive of the road, present in the small prose of V. Birchak of the 20’s and 40’s of the twentieth century, is a motive of emigrant hardships, searching for himself in a new, non-hostile world.

All the prose works of V. Birchak confirm his views on the important role in the history of the state creation of each strong person, and not the crowd. The author in many of his stories skillfully depicts the customization of emigre heroes under the inadequate claims that seem to be invented deliberately to mock exiles from Ukraine: as a rule, educated, intelligent, educated, patient in the experience of difficulties, able to adapt and continuously teach something new , responsible and decent in the relationship with the environment. They do not have excessive pride, do not show self-defeatism, do not declare their exclusiveness, as former fighters for the freedom of Ukraine. They also do not squeal, but engage in everyday work to survive until the time comes again to take up arms and win. Survive in difficulty, poverty, humiliation of their dignity helps optimism.
EUROCENTRISM AS A SOURCE OF YURIY KOSACH’S OUTLOOK
Authors: Radyshevsky Rostyslav
Published: December 2019

The article «Eurocentrism as the source of Y. Kosach’s outlook» investigates the problem of Occident and Ori- ent in Y. Kosach’s literary-critical legacy. The concepts of «Europe» and «West» in the writer’s apprehension are considered in details. The conceptualization of epochs and historical figures in the context of culture, politics and history is traced. The main attention is paid to the problem of the affinity of Ukrainian and Western European cultures, the basis of which is the common feature – the synthesis of experiment and tradition, what matches Ukrainian nation as a European nation with the millennial state past.

The problem of eternal connection of Ukraine with the West’s tradition is seen as the main axis around which Kosach concentrated all other problems. At the same time, attention is also focused on the unifying features of the Ukrainian writ- ers’ style, which Kosach distinguishes for analysis, meaning not the «form of content», but the «style of content». Similarly, in the close connection with the problem of the occidentality of Ukrainian culture, the problem of the «Ukrainian mission of the defense of Western Civilization» and the painful problems connected not only with Ukrainian history but also with the Ukrainian character, the Ukrainian way of thinking are considered.

The author emphasizes that as a result of a poetic research, the artist created the myth-poetic conception of Ukrainian state existence, imagining Ukraine as «Imperium Ucrainum», «Third Rome», convinced that empires do not die, continuing to live in myths, capturing the thoughts of contemporaries, becoming a ground on which the former might and glory of the state are reviving. Аccording to Kosach, just writers perform the function of development and dissemination of national myths in society – repeatedly in the history of mankind the works of literature played the role of a vector of direction of public tastes. Thus, «Aeneid» by Virgil became the cornerstone of the imperial ideological concept by Octavian Augustus, and «An- dromaque» by Racine led the political ground for the legitimate rule of Louis XIV from the rulers of Troy.

Much attention is paid to Kosach’s criticism of «Polish mythology» by A. Mickiewicz and H. Sienkievicz; dependence between «Polish mythology» and creation of own Kosach’s mythology is established in the literary essay «On the guard of the nation». The article emphasizes the relevance and far-sightedness of Y. Kosach’s views through the conception of such an old-new concept as «information warfare».
Automation of compilation of working programs of educational disciplines
Authors: Safonov Egor I. , Chernavsky Alexey Yu.
Published: December 2019

The article describes the automation of the process of compiling work programs for academic disciplines by teachers of Yugra State University. When drawing up a work program, the teaching staff fills in the document manually in accordance with the curriculum, while there is always a risk of incorrect filling, errors and other shortcomings. Automation of work programs will allow you to fill in most of the dynamically changing fields automatically, while the program will check the correct filling of data, such as the distribution of hours of work from the curriculum for the selected discipline. To automate the described process, it was decided to develop a web application. The authors provide an overview of analogues. A study of the process of compiling work programs. A list of fields to be automated has been defined. A study of the database of Yugra State University. The description of the technologies and languages ​​used in the development of the web application is given.
FLEXIBLE MANUFACTURING TENDENCIES AND IMPROVEMENTS WITH VISUAL SENSORING
Authors: BRONNİKOV Artem , NEVLİUDOV İgor , TSYMBAL Oleksandr
Published: December 2019

The proposed article contains the
review of modern tendencies in flexible manufacturing systems. The applications
of intelligent control systems for modern manufacturing are considered. As one
of key elements of production control, article deals with tasks of visual
monitoring for distributed production workspaces.
DETECTION OF “WALL THINNING” TYPE DEFECTS IN PIPELINES BY THERMAL METHOD
Authors: OREL Roman , MESHKOV Sergey , STOROZHENKO Volodymyr , MYAGKİY Aleksandr
Published: December 2019

A
thermophysical model of a pipe with a local defect of the “wall thinning” type
is developed. Calculations of thermal anomalies for pipelines with different
parameters of hidden defects are performed, illustrating the possibility of
using the thermal method of nondestructive testing. The conditions and methods
of thermal control of individual sections of pipelines are specified. Thermal
imaging examination of steam pipelines of the main condensate of the nuclear
power plant was carried out. External factors that make it difficult to detect
hidden defects (the influence of external lighting, cylindrical shape of
controlled objects, powerful external heat sources) are analyzed. It was found
that cavitation phenomena significantly increase the temperature drop in the
locations of local defects. The possibility of using the thermal method of
nondestructive testing for rapid detection of hidden defects such as “wall
thinning” in the pipelines of the main condensate has been confirmed
experimentally
BUILDING A SYSTEM FOR LOGISTICS INFORMATION SYSTEMS EVALUATION
Authors: OMAROV Murad , SUKHOMLYNOV Artem
Published: December 2019

The article analyzes the criteria by which to evaluate the logistics systems and shows the process of forming a system of logistics information systems evaluation, based on the criteria used by qualitative scales. The article also analyzes modern technologies of information systems development, in particular the technology of object-relational mapping. There has been considered the application of the built evaluation system in the research logistics information system.
Impact of cortical mastoidectomy on tympanoplasty for recurrent suppurative otitis media: a prospective study
Authors: Sisodia Shalini Singh , Sriprakash Vinnakota
Published: December 2019

Background: Chronic suppurative otitis media condition is characterized by an ear discharge and a perforation in the tympanic membrane. Tympanoplasty and tympanoplasty with mastoidectomy are the two common surgeries performed to manage this condition.

Methods: 50 patients were divided into two groups of 25 each. On Group I, tympanoplasty alone was done and on Group II tympanoplasty along with mastoidectomy was performed and outcome was noted.  

Results: The most common age group to be affected was 21-30 years. Discharge of 1-3 years was observed in 32% in Group I and 36% in Group II. 84% in Group I and 72% in Group II had mild hearing loss, and in both the groups, moderate perforations were more common. 84% of the patients in Group I and 88% in group II showed acceptance to the surgeries and the hearing gain in both the groups was around 10.

Conclusions: This study shows that tympanoplasty with mastoidectomy has no added advantage over tympanoplasty alone in the patients with chronic suppurative otitis media.
Suspension damping optimization using genetic algorithms
Authors: HEMATİ Ali , SHOOSHTARİ Alireza
Published: December 2019

Vehicle
ride comfort is a function of the frequency of transmitting vibrations to
passengers from road irregularities. The objective of this research is to provide a systematic method into the requirement
of the passive suspension based on genetic algorithm (GA). Objective function of GA method is driver’s seat acceleration to
provide driver ride comfort. The passive suspension damping coefficient and
driver’s seat suspension damping coefficient have been optimized. In this
paper, a vehicle with eight degrees of freedom has been simulated to achieve
driver’s seat comfort.  Analytical
results explained by mathematical equations presented in the graphical form
have been included.
Transmembrane segment M2 of glycine receptor as a model system for the pore-forming structure of ion channels.
Authors: Bednarczyk Piotr , Szewczyk Adam , Dołowy Krzysztof
Published: December 2019

The glycine receptor belongs to the ligand-gated ion channel superfamily. It is a chloride conducting channel composed of four transmembrane domains. It was previously shown that the second transmembrane domain (M2) of the glycine receptor forms an ion conduction pathway throughout lipid bilayers. The amino-acid sequence of the transmembrane segment M2 of the glycine receptor has a high homology to all receptors of the ligand-gated ion channel superfamily. In our report, we have used a synthetic M2 peptide. It was incorporated into a planar membrane of known lipid composition and currents induced by M2 were measured by the Black Lipid Membrane technique. When the planar lipid bilayer was composed of 75% phosphatidylethanolamine and 25% phosphatidylserine, the reversal potential measured in a 150/600 mM KCl (cis/trans) gradient was -19 mV suggesting that the examined >pore was preferential to anions, P(K)/P(Cl) = 0.25. In contrast, when 75% phosphatidylserine and 25% phosphatidylethanolamine was used, the reversal potential was +20 mV and the >pore was preferential to cations, P(K)/P(Cl) = 4.36. Single-channel currents were recorded with two predominant amplitudes corresponding to the main-conductance and sub-conductance states. Both conductance states (about 12 pS and 30 pS) were measured in a symmetric solution of 50 mM KCl. The observed single-channel properties suggest that the selectivity and conductance of the pore formed by the M2 peptide of the glycine receptor depend on the lipid composition of the planar bilayer.
Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.
Authors: Czajkowski Rafał , Barańska Jolanta
Published: December 2019

In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y(2) receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y(1) and P2Y(12). The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.
Role of Virechana Karma In Mrit Bhakshana Janya Pandu Roga W.S.R. Gandupada Krimi
Authors: Kaushik Dr. Devender , Sahay Dr. Sweta
Published: December 2019

Background: Krimi roga is one of the most common diseases.in Ayurvedic classics most of the Acharyas gave extensive explainations regarding the krimi roga. Gandupada krimi is one of the pureeshaja krimi mentioned in classics. Ascaris Lumbricoides has the close resemblance to the Gandupada krimi, it is the most common Helminthic infestations. It has a world- wide distribution, but the highest prevalence occurs in tropical & sub- tropical regions and areas with inadequate sanitation, Poverty, ignorance, lack of hygiene maintenance, bad sanitation and use of un cooked food or improper washing of food materials, eating soil etc. are the important factors for spreading helminthic infection in developing countries like India. In Ayurveda Virechana Karma is mentioned as the ideal treatment for krimi kostha & pandu.

Objective : To study the role of Virechana karma in Mritbhakshana janya Pandu roga w.s.r. Gandupada krimi (Ascariasis)

Design: Randomized open angle clinical study.

Study: The study took place at Gaur Brahaman Ayurvedic College Brahamanwas Rohtak India.

Participant: The 40 participants were registered for study irrespective of their sex, cast, race etc.

Intervention: Role of virechana in Mritbhakshana janya panduroga WSR Gandupada krimi.

Result: 100% result of virechana found in Gandupada krimi.

Conclusion: In the present clinical study Role of Virechana karma in Mridbhakshana janya pandu offered better results in pacifying almost entire range of symptomatology.
Kecerdasan Spiritual dan Komitmen Organisasi Mahasiswa Pengurus Organisasi
Authors: Yuliani Tri , Komalasari Shanty
Published: December 2019

Lack of organizational commitment often occurs among students who are administrators of the organization; they are still less able to set rules for themselves. These abilities are related to how one judges and interpret each action or commonly referred to as spiritual intelligence. This study aims to examine the relationship between spiritual intelligence and organizational commitment. The population in this study amounted to 919 people, with a sample of 92 administrators of UKK and UKM in the 2017/2018 period at UIN Antasari Banjarmasin. The sampling technique in this study uses probability sampling with a type of sample random sampling. The instrument of data collection uses the scale of organizational commitment and spiritual intelligence of the Likert model and analysis using Product Moment correlation with the help of SPSS 21.0. Based on the calculation results show that the level of organizational commitment and spiritual intelligence of students is classified as moderate. The results of the correlation test indicate a significant positive relationship between the two variables (p = 0.002, p <0.05). The higher the spiritual intelligence, the higher the student's organizational commitment and vice versa, the lower the spiritual intelligence, the lower the student's organizational commitment.
Pathosystem Solanum lycopersicum-Phytophthora infestans in Chapingo, Mexico. Expected, observed and simulated
Authors: Delesma-Morales Lucio , Lozoya-Saldaña Héctor , Rodríguez-Pérez J. Enrique , Díaz-de la Cruz Jaime B.
Published: December 2019

Phytophthora infestans es afectado por factores bióticos y abióticos que pueden hacer variar su patogenicidad. En tierras altas de México, la variabilidad genética de P. infestans, bajas temperaturas, alta humedad relativa y luz favorecen su expresión e influyen en la eficacia de la infección. Este trabajo analizó el progreso de infección de P. infestans respecto a lo esperado, observado y simulado durante dos ciclos de campo en Chapingo, México, con el objetivo de documentar y cuantificar el progreso de la infección foliar por P. infestans en diferentes líneas de jitomate con diferentes niveles de resistencia. Así como validar un modelo predictivo. Con el registro de 10 años de datos meteorológicos, se predijeron cinco situaciones con cuatro a diez ciclos de infección de 8 a 13 h cada uno. En comparación con las predicciones, el efecto observado de área bajo la curva de progreso de la enfermedad (AUDPC) y sus componentes (RAUDPC y RaRAUDPC) fueron significativos, con bajo coeficiente de variación. Se concluye que entre los escenarios esperados, observados y simulados existe una estrecha relación para predecir epidemias de P. infestans. Esto confirma que LATEBLIGHT es útil para simular y predecir la epidemia de tizón tardío, en condiciones atmosféricas de Chapingo.
The role of education in human nature and future human design according to Edgar Morin
Authors: Demirel Funda
Published: December 2019

Understanding the structure of human nature is an important element in determining educational practices. Recent developments in the field of science, culture and technology today require us to reconsider the developments and changes in human nature. Therefore, while determining the qualifications and principles that should play a role in the education of the future, it is necessary to first evaluate how human that is both the subject and object of education in perceived in the 21st century. While all the disciplines are essentially examining human being from different perspectives and trying to understand its nature, Edgar Morin, a contemporary philosopher and sociologist, considers the issue from a different perspective and thinks that the reality of human nature can be reached only when the disciplines are considered as a whole. Morin, who thinks that uncertainties will be clarified with an integrated education, has suggestions for the education of the future.

Keywords: Edgar Morin, philosophy of education, education of future, human nature.
Design of smart stick for visually impaired people using Arduino
Authors: Salama Ramiz , Ayoub Ahmad
Published: December 2019

Nowadays, blind or impaired people are facing a lot of problems in their daily life since it is not easy for them to move, which is very dangerous. There are about 37 million visually impaired people across the globe according to the World Health Organization. People with these problems mostly depend on others, for example, a friend, or their trained dog while movÄ±ng outside. Thus, we were motivated to develop a smart stick to solve this problem. The smart stick, integrated with an ultrasonic sensor, buzzer and vibrator, can detect obstacles in the path of the blind people. The buzzer and vibration motor are activated when any obstacle is detected to alert the blind person. This work proposes a low-cost ultrasonic smart blind stick for blind people so that they can move from one place to another in an easy, safe and independent manner. The system was designed and programmed using C language.

Keywords: Arduino Uno, Arduino IDE, ultrasonic sensor, buzzer, motor.
Geometry of the form and designs of Ilkhani tombs' tower of Azerbaijan (Case study: Qarabagh Bardaeh tomb' tower)
Authors: Tavakkoli Behrouz , Cinmarasl Raana
Published: December 2019

The seventh and eighth centuries of the Hijri calender were the era when Azerbaijan's architecture flourished. During this period, a special style of funerary architecture was developed in the form of a tower-shaped tomb, the scope of its effects extending from Azerbaijan and reaching Khorasan and Turkestan in the east, and Asia Minor and Mamluk Egypt. Considering the centrality of Azerbaijan during the period of the Ilkhanite of this region, the architectural styles flourished in this temporal and spatial period, which later became known as Azeri-style architecture. Parallel to other religious monuments, the tower-shaped tombs found a privileged position in Islamic architecture. Its best examples are the mausoleum tower of Bardaeh in Qarabagh, Sheikh Safi, and Sheikh Heydar, Soltanieh, Ghaffarieh and Qara Baghlar. The purpose of the present study is to recognize the architectural and decorative structure, and to analyze the geometric patterns used in the Azerbaijan tombs, with emphasis on the Qarabagh Bardaeh tomb tower, as a persistent pattern. In order to achieve these goals, the tombs were studied with an interpretive and qualitative strategy, through historical and library studies and field analysis. The designs and decorations were documented, recognized and analyzed.
Memorias sociales y culturales. Un debate en construcción
Authors: Acuña Rodríguez Olga Yanet
Published: December 2019

Editorial
Entre el «deber de memoria» y el uso político del olvido: México y Argentina frente al pasado reciente
Authors: Perochena Camila
Published: December 2019

En este artículo se analizan la memoria oficial del pasado violento y traumático en las presidencias de Cristina Fernández de Kirchner en Argentina (2007-2015) y de Felipe Calderón en México (2006-2012). En términos metodológicos este artículo adopta una comparación por contraste que busca iluminar características específicas de cada caso en particular y mostrar cómo dichas características afectan el proceso más general. El corpus documental utilizado son los discursos presidenciales y las iniciativas oficiales en relación con el pasado reciente de cada país. Ambas experiencias pueden contrastarse a partir de la tensión entre memoria y olvido. El argumento postula que el kirchnerismo se inscribió en una política de «deber de memoria», en sintonía con un uso político del pasado polarizador, y el panismo en la tendencia del «derecho al olvido» en consonancia con un uso político del pasado de carácter reconciliador.
Optimization of the Immobilization Conditions of Horseradish Peroxidase on TiO2-COOH nanoparticles by Box-Behnken Design
Authors: Şahin Selmihan
Published: December 2019

In this
study, TiO2 nanoparticles were prepared and -COOH functionalized
with 3-(3,4-dihydroxyphenyl) propionic acid. The characterization of
nanoparticles was performed by FTIR, TEM, EDS and XRD. HRP was immobilized on
those nanoparticles by EDC/NHS coupling reaction. The immobilization conditions
of HRP including A: enzyme concentration (0.5-1.5 mg/mL), B: immobilization pH
(4.0-8.0), C: immobilization temperature (4-50°C), D: immobilization time (1-20
h) were optimized by response surface methodology and Box-Behnken design. The
optimized immobilization conditions were identified as 0.5 mg/mL HRP, at pH
5.5, 40 °C for 8 h for activity of immobilized HRP, 1.5 mg/mL HRP, at pH 4 and
18°C for 20 h for protein binding yield (%). At these optimum conditions, the experimental
value for the activity of immobilized HRP was 80.39 U ± 1.06; protein binding
yield was 94.25 ± 3.58%. Moreover, the optimum temperature and pH of free and
immobilized enzyme were determined as 50°C and 4.0; 50°C and 3.5, respectively.
The activity of the immobilized HRP sustained 52% of its initial activity after
10 days storage at 4°C. Furthermore,
the immobilized HRP sustained 48% of its initial activity after 6 consecutive
reactions.