bluuebunny/crossref_metadata_2025 huggingface dataset:
Principles and applications of optogenetics in developmental biology
Authors: Krueger Daniel , Izquierdo Emiliano , Viswanathan Ranjith , Hartmann Jonas , Pallares Cartes Cristina , De Renzis Stefano
Published: October 2019

The development of multicellular organisms is controlled by highly dynamic molecular and cellular processes organized in spatially restricted patterns. Recent advances in optogenetics are allowing protein function to be controlled with the precision of a pulse of laser light in vivo, providing a powerful new tool to perturb developmental processes at a wide range of spatiotemporal scales. In this Primer, we describe the most commonly used optogenetic tools, their application in developmental biology and in the nascent field of synthetic morphogenesis.
Case Report: Xanthogranulomatous prostatitis, a difficult differential diagnosis of prostate adenocarcinoma
Authors: El Moussaoui Reda , El Moussaoui Ali , Dakir Mohamed , Benkirane Amal
Published: October 2019

Background: Xanthogranulomatous prostatitis is a rare benign inflammatory process of the prostate. Clinical, biochemical and imaging similarities make xanthogranulomatous prostatitis a difficult differential diagnosis of prostatic adenocarcinoma.

Case presentation: We report the case of a 62 year-old diabetic patient, with 3 months of lower urinary tract symptoms. On digital rectal examination, the prostate was hard and nodular. Initial prostate-specific antigen (PSA) was 43.97 ng/mL, with urine analysis and transabdominal ultrasonography not showing any alterations. A multiparametric magnetic resonance imaging (mpMRI) of the prostate was performed and showed two foci that were classified as PI-RADS 4 lesions. A transrectal ultrasound guided prostate biopsy was then realized. After an initial suspicion of prostatic adenocarcinoma, on clinical, biochemical and radiological grounds, histopathological examination revealed a suppurated xanthogranulomatous prostatitis, with no evidence of malignancy.

Conclusions: Xanthogranulomatous prostatitis is an uncommon benign inflammatory condition of the prostate that can clinically, biochemically and even radiologically simulate prostatic adenocarcinoma. We advise that if an older male with low urinary tract symptoms and a hard nodular prostate on digital rectal examination presents, the first diagnosis that one should think of is prostate adenocarcinoma, especially if PSA is high. However, only histopathological examination can differentiate with certitude between these two pathologies and is therefore essential for the diagnosis of xanthogranulomatous prostatitis.
Accounting of Obligations That Are Formed in Connection with the Employees’ Right for Paid Leave
Authors: Крылов Дмитрий , Krylov Dmitriy
Published: October 2019

Th e article examines the obligations that arise from the parties to the employment contract in connection with the established labour laws the right of employees for paid leave. In the article, it is off ered to refl ect the employee’s obligations, which arise from providing them paid leave for not worked months, as accounts receivable. Such a change in the method of refl ecting the obligations of the employees will allow Russian accounting to be complied with labor law and improve the quality of fi nancial statements.
New in the Organization of Investment Processes
Authors: Смирнов Е. , Smirnov E.
Published: October 2019

Last summer, the President of the Russian Federation signed Federal Law dated August 2, 2019 No. 259-FZ “On attracting investments using investment platforms and on amending certain legislative acts of the Russian Federation”. Financial analysts believe that this legal act will signifi cantly increase funding for small and medium-sized businesses.
Cash Flow Statement: Russian and International practice
Authors: Шмарова Л. , Shmarova L. , Грунина Н. , Grunina N.
Published: October 2019

Th e work deals with the issues of the Russian and International practice of preparation of cash fl ows statements of companies. It focuses on the historical aspects of the topic, and also compares and analyses the requirements of the standards governing the Cash Flow statement preparation process in Russia and abroad: (PBU) 23/2011 and IAS 7.
Target Settings and Their Impact on the Transformation of Accounting
Authors: Миславская Н. , Mislavskaya N.
Published: October 2019

Th e article is devoted to the analysis of the current state of accounting knowledge and, as a result, accounting practices that are permanently transformed into separate accounting areas aimed at satisfying the information interests of certain groups of users of fi nancial, tax, social and other reporting. Th e author focuses on the impossibility of achieving economic effi ciency of organizations, in the setting of distorted or false targets of the national accounting system.
Relações Internacionais na Extensão Universitária: o tripé do ensino, pesquisa e extensão levado à educação básica | International Relations in the Academic Outreach Project: the tripod of teaching, research and outreach projects led to the secondary education
Authors: Maia Marrielle , Araújo Ana Beatriz , Brunetta Pedro Costa
Published: October 2019

A exigência legal de que os cursos de graduação reservem 10% de sua carga horária para a realização de atividades de extensão coloca para os cursos de Relações Internacionais o desafio de repensar suas práticas de extensão. O presente artigo busca contribuir com esse movimento de reflexão ao apresentar uma ação de extensão que leva para a educação básica o debate sobre o papel das organizações internacionais e a relação entre o global e local. A proposta é inovadora já na sua concepção, ou seja, do preparo dos alunos para a extensão na disciplina “Economia e Organizações Internacionais”, onde são empregadas metodologias ativas (role playing). Na parceria com as instituições de educação básica, as atividades de simulação vivenciadas pelos alunos da graduação são adaptadas para a realidade da educação básica junto com os professores de instituições parceiras. Após essa adaptação, os discentes da graduação ministram a atividade aos estudantes do ensino básico.Palavras-chave: Relações Internacionais; Ensino, Pesquisa e Extensão; Organizações Internacionais ABSTRACTThe Brazilian legal exigence of setting 10% of the graduation courses’ credits to outreach activities poses the challenge of rethinking their practices for the graduations courses in International Relations. The present article contributes to that reflexion by presenting an outreach activity that takes to elementary schools the debate on international organizations and the connections between global and local. The proposition is innovative in its conception: from the activity preparation of the undergraduate students inside the “Economy and International Organizations” discipline, where active methodologies (role playing) are applied. In the partnership with elementary schools, the modeling activities experienced by the undergraduate students are adapted to the school reality jointly with teachers from the partner school. After the adaptation, the undergraduate students impart the activity to the elementary students.Keywords: International Relations; Teaching, researching and outreach; International Organizations. Recebido em: 06 nov.2018 | Aceito em: 24 ago.2019
Elementos para elaboração de um desenho de pesquisa | Elements to formulate a research design
Authors: Lisboa Marcelino Teixeira
Published: October 2019

O texto tem o intuito de apresentar as ideias básicas para formulação de desenhos de pesquisa, com foco em estudantes em nível de graduação. Desenvolve-se a ideia de que um desenho de pesquisa deve ocupar-se inicialmente, de definir um objeto, uma pergunta, definir uma teoria a ser utilizada, elaborar uma hipótese, tratar das fontes e escolher o método adequado. Entende-se que esses sejam os passos iniciais fundamentais que devem ser seguidos pelos pesquisadores que realizam seu primeiro trabalho de maior envergadura, como uma monografia de conclusão de graduação.Palavras-chave: Projeto de Pesquisa; Relações Internacionais; Metodologia.ABSTRACTThe text intends to present the basic ideas for the formulation of research project, focusing on undergraduate students. The idea is developed that a research design should initially and interactively focus on defining an object, a question, defining a theory to be used, elaborating a hypothesis, dealing with the sources, and choosing the appropriate method. These are the fundamental initial steps that must be followed by the researchers who carry out their first major work, such as a graduate monograph.Keywords: Research Project; International Relations; Methodology.Recebido em 23 nov. 2018 | Aceito em 30 ago. 2019
Localization of Tfap2β, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye
Authors: Wan Yong , White Casey , Robert Nadine , Rogers Matthew B. , Szabo-Rogers Heather L.
Published: October 2019

Optic development involves sequential interactions between several different tissue types, including the overlying ectoderm, adjacent mesoderm, and neural crest mesenchyme and the neuroectoderm. In an ongoing expression screen, we identified that Tfap2β, Casq2, Penk, Zic1, and Zic3 are expressed in unique cell types in and around the developing eye. Tfap2β, Zic1, and Zic3 are transcription factors, Casq2 is a calcium binding protein and Penk is a neurotransmitter. Tfap2β, Zic1, and Zic3 have reported roles in brain and craniofacial development, while Casq2 and Penk have unknown roles. These five genes are expressed in the major tissue types in the eye, including the muscles, nerves, cornea, and sclera. Penk expression is found in the sclera and perichondrium. At E12.5 and E15.5, the extra-ocular muscles express Casq2, the entire neural retina expresses Zic1, and Zic3 is expressed in the optic disk and lip of the optic cup. The expression of Tfap2β expanded from corneal epithelium to the neural retina between E12.5 to E15.5. These genes are expressed in similar domains as Hedgehog ( Gli1, and Ptch1) and the Wnt ( Lef1) pathways. The expression patterns of these five genes warrant further study to determine their role in eye morphogenesis:
Pocket play: Playful persona as an approach to stress-reduction in an elementary school program
Authors: Webb Erinn
Published: October 2019

Past experiences of trauma can impede children’s learning and success. Playful interactions between skilled counsellors and students can help mitigate the impact of trauma. The author presents case examples of brief drama therapeutic interventions in a school-based program called
ALIVE. The article covers the type of persona, qualities and skills cultivated by a counsellor in the ALIVE program, with comparison to medical clowns working in hospitals, pointing out the commonalities, differences and challenges involved.
Conference Reviews
Authors: Lepere Refiloe
Published: October 2019

Critical Pedagogies in Arts Therapies 2019: Curating dignity and other points-of-view
Os artefactos metálicos da Idade do Ferro do Monte Molião (Lagos, Portugal)
Authors: Pereira Carlos , Arruda Ana Margarida , Sousa Elisa
Published: October 2019

Passados mais de dez anos após a primeira campanha de escavações realizada em Monte Molião, e apesar de o sítio ter sido já alvo de inúmeras publicações, o conjunto de artefactos metálicos da Idade do Ferro aguardava ainda a sua divulgação. Neste trabalho, apresenta-se e estuda-se a totalidade dos elementos metálicos recolhidos nos contextos sidéricos, que se analisam de acordo com as várias categorias em que se podem incluir, concretamente: arquitectura e mobiliário, uso pessoal, e utilitários.Cada um dos artefactos foi analisado individualmente, tendo em atenção o seu contexto de recolha, bem como os dados cronológicos que os seus paralelos permitiram obter. A discussão sobre a funcionalidade de muitos deles permitiu uma aproximação à realidade social e económica da comunidade que habitou o sítio e das suas relações inter-regionais, lidas em função do mobiliário utilizado, do vestuário usado e das actividades económicas praticadas.
Doce yacimientos para el conocimiento del “Reino de Tartessos”. El Decreto 3833/1973: biografía de una declaración no consumada
Authors: García Fernández Francisco José , Del Espino Hidalgo Blanca
Published: October 2019

A principios de 1974 fue publicado un decreto por el Ministerio de Educación y Ciencia en el que declaraban de utilidad pública una serie de yacimientos que se consideraban representativos de la cultura tartésica. La fascinación originada por los descubrimientos arqueológicos que se sucedieron en Andalucía a mediados del siglo XX produjo también una toma de conciencia sobre el riesgo de pérdida de gran parte de este patrimonio ante el desarrollismo urbano y rural. Examinamos a continuación el alcance real de esta disposición a través del análisis particularizado de todos los casos y su valoración conjunta posterior, atendiendo tanto al aprovechamiento científico como a las medidas de protección, conservación y difusión adoptadas en estos yacimientos desde la promulgación del decreto hasta la actualidad. Llegamos a la conclusión de que la aplicación del Decreto tuvo poca continuidad y fue muy desigual, en parte motivado por los cambios políticos que se sucedieron en los años siguientes, por lo que la casuística es muy variada.
Más que adobes. La construcción con tierra durante los siglos IV-III a.C. en el Área 11 de Giribaile (Vilches, Jaén)
Authors: Ortiz Villarejo Antonio Jesús , Gutiérrez Soler Luis María , Alejo Armijo María
Published: October 2019

La campaña de excavación arqueológica desarrollada durante el año 2014 en la meseta de Giribaile documentó un espacio de almacenaje, el Área 11, en excelente estado de conservación que, entre otros materiales, ha proporcionado un total de 342 fragmentos de material de construcción divididos en los grupos: ladrillo, argamasa, revoque e indeterminados. La generación de una base de datos para su gestión y análisis estadístico así como la realización de los estudios de DRX composicional, análisis de carbonatos y pruebas de resistencia, han permitido avanzar  tanto en el conocimiento del proceso de fabricación, cocción en frío, como caracterizar de manera precisa su composición y la realización de un catálogo de estas piezas que puede ser una nueva referencia en este campo.
Civitates y comunidades de la Asturia transmontana. A propósito de los Luggoni Arganticaeni
Authors: Orejas Saco del Valle Almudena , Fernández Ochoa Carmen
Published: October 2019

La dominación de Roma sobre las comunidades indígenas dio lugar a la aparición de nuevas relaciones sociales, que fueron la base de las nuevas civitates y del surgimiento, dentro de ellas, de grupos de poder. En la Asturia transmontana, los lugones constituyeron una de las civitates más importantes, según se desprende de las fuentes literarias y epigráficas. Sin embargo, poco se sabe sobre las características de su poblamiento y organización. A partir de la revisión del registro epigráfico y arqueológico, se propone en este artículo profundizar en las comunidades del oriente de Asturia y sus relaciones con civitates vecinas, en especial la vadiniense.El epígrafe dedicado por los luggoni arganticaeni que se conserva en la iglesia de Grases (Villaviciosa, Asturias) ha sido tradicionalmente considerado una inscripción votiva. Solo en algunos trabajos recientes se ha propuesto su lectura como funeraria. En estas páginas se revisa el texto y se propone una nueva interpretación, atendiendo tanto a otras referencias epigráficas del noroeste de la península ibérica, como al contexto arqueológico de la zona. Se analizan tanto los dedicantes, los luggoni arganticaeni, como el individuo al que se dedica el monumento funerario y su relación con este grupo, a partir de la propuesta de reconstruir su nombre como [Pent]ovius Tabaliaenus.
The CDC PNU-1 criteria for diagnosis of ventilator-associated pneumonia
Authors: Ningtiar Hapsari Widya , Lestari Dwi Putri , Kusumastuti Neurinda Permata , Setyaningtyas Arina , Setyoningrum Retno Asih , Dharmawati Ira , Azis Abdul Latief
Published: October 2019

Background Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the pediatric intensive care unit (PICU), with mortality rates of up to 50%. Post-mortem pulmonary examination is considered to be the gold standard for diagnosis of VAP, but is impossible for routine application. The sensitivity and specificity of Clinical Pulmonary Infection Score (CPIS) are considered to be similar to the those of the gold standard, but the Centers for Disease Control and Prevention PNU-1 (CDC PNU-1) is simpler and not invasive, compared to the CPIS.

Objective To evaluate the level of agreement between CDC PNU-1 and CPIS criteria in diagnosing VAP.

Methods This cross-sectional study was conducted in the PICU at Dr. Soetomo Hospital, Surabaya from June to October 2018. Subjects were children aged 1 month–18 years who had been intubated for more than 48 hours. The VAP diagnoses were made by CDC PNU-1 and CPIS criteria. The level of agreement between the two methods was evaluated by Cohen’s Kappa test using SPSS Statistics Base 21.0 software.

Results hirty-six subjects were evaluated using CDC PNU-1 and CPIS criteria. Subjects’ mean age was 3.5 (SD 4.7) years. Amongst 19 patients with VAP, 14 were diagnosed by CPIS criteria and 17 were diagnosed by CDC PNU-1 criteria. The level of agreement between the CDC PNU-1 and CPIS criteria was good (Kappa 0.61; 95%CI 0.31 to 0.83). The CDC PNU-1 had sensitivity 0.85, specificity 0.77, positive predictive value (PPV) 0.70, and negative predictive value (NPV) 0.89.

Conclusion The CDC PNU-1 criteria has a good level of agreement with CPIS criteria in diagnosing VAP.
Levothyroxine use and thyroid gland volumes in children with autoimmune thyroiditis: a systematic review and meta-analysis
Authors: Moelyo Annang Giri , Widyahening Indah Suci , Tridjaja Bambang
Published: October 2019

Background Autoimmune thyroiditis may manifest as overt hypothyroidism, subclinical hypothyroidism, euthyroidism, or hyperthyroidism in children. Although there is no consensus on treating euthyroidism and autoimmune thyroiditis in children, some studies have demonstrated the efficacy of levothyroxine in reducing thyroid volume, improving thyroid function, and stabilizing the immunological process.
Objective To determine the effect of levothyroxine on thyroid gland volume changes, thyroid function, and thyroid antibodies in euthyroid children with autoimmune thyroiditis.
Methods We performed a literature search of electronic databases (the Cochrane Library, MEDLINE, EBSCO, ProQuest, clinicaltrials.gov, and other sources, as well as a non-electronic search (searching journals and conference proceedings by hand) to identify studies of euthyroid children with autoimmune thyroiditis published by August 2018. Only English-language articles were included in the search (electronic and non-electronic). Randomized controlled trials that compared levothyroxine with a control (placebo or no treatment) in euthyroid children with autoimmune thyroiditis were selected. The outcome measures were thyroid volume changes, thyroid function, and thyroid antibody levels in euthyroid children with autoimmune thyroiditis. Two authors independently extracted the data, assessed the risk of bias, and analyzed the pooled data from the included studies using a random effects model. The same authors performed a sensitivity analysis.
Results We identified 57 studies. Of these, three studies, involving 97 subjects (51 subjects in an intervention group and 46 subjects in the control group) were selected for inclusion in a systematic review/meta-analysis. The meta-analysis revealed a significant difference in mean thyroid volume changes between the two groups (-1.10 SDs; 95%CI -1.56 to -0.64; P<0.0001; I2=6%). The mean difference in the thyroid-stimulating hormone (TSH) change of the two groups was -1.82 mU/L (95%CI -3.52 to -0.11; I2=87%; P=0.04). The standardized mean difference in free thyroxine (fT4) change of the two groups was 0.82 pmol/L (95%CI -1.14 to 2.78; I2=89%; P=0.41).
Conclusion In euthyroid children with autoimmune thyroiditis, levothyroxine treatment reduces the thyroid volume better. The TSH level change in the intervention group is better than those in the control group. Levothyroxine treatment did not significantly improve free T4.
ŚWIADOMOŚĆ PODRĘCZNIKOWA NAUCZYCIELA. TEORETYCZNE RAMY OPISU
Authors: Andrzejewska Ewa
Published: October 2019

The following article aims to explain the concept of textbook awareness that in foreign language teaching literature is used to denote an element of teacher’s professional competence. The underpinnings of this concept are based on an analysis of its definition as postulated by Koenig (2010) and a critical survey of subject literature on the teacher-textbook relationship. This article shows how the concept of text-book awareness is justified and can be implemented. The significance of the role of textbook awareness in teacher’s didactic practice and professional development is highlighted.
KSZTAŁTOWANIE POSTAWY OTWARTOŚCI INTERKULTUROWEJ NAUCZYCIELI JĘZYKÓW OBCYCH W ŚWIETLE ZALECEŃ UNII EUROPEJSKIEJ I NA PRZYKŁADZIE ASYSTENTURY COMENIUSA
Authors: Grabowska Anna
Published: October 2019

Learning a foreign language is not only limited to the development of linguistic competences. Learning a language also means learning about the culture and life of another country, which very often may be a future destination for educational or professional purposes for foreign language learners. Teaching intercultural competences within foreign language education is a subject of academic research. Official documents of the European Union, which affect the national language education strategies, also confirm the importance developing intercultural competence. Experts agree that foreign language teachers play a crucial role in building intercultural awareness of their pupils. Thus, in order to act as intercultural mediators they should acquire intercultural skills and competences themselves. This article analyses the development of future foreign language teachers’ intercultural competences as a consequence of their participation in Comenius Assistantship, a component of the Lifelong Learning Programme.
OCENA ZEWNĘTRZNA A SAMOOCENA – ROZBIEŻNOŚCI I PUNKTY STYCZNE
Authors: Mihułka Krystyna
Published: October 2019

The aim of this article is to discuss two types of evaluation of students’ language skills: external evaluation (objective) and self-assessment (subjective). The article presents the results of the study conducted among students of German Philology at the University of Rzeszów. The language proficiency level of respondents was assessed three times by means of certified language tests and a self-assessment questionnaire developed in accordance with the CEFR guidelines (2001). The data provided the answer to the main research question: whether and to what extent the students’ self-assessment corresponds to their results achieved in the standardized tests.
HSK – JĘZYKOWY PASZPORT DO CHIN. O EGZAMINIE Z PERSPEKTYWY POLAKÓW
Authors: Paliszewska-Mojsiuk Monika , Sroka-Grądziel Anna
Published: October 2019

HSK (Hanyu Shuiping Kaoshi – 汉语水平考试) and HSKK (Hanyu Shuiping Kouyu Kaoshi – 汉语水平口语考试) are the official Chinese language proficiency examinations for foreigners developed by Hanban (Office of Chinese Language Council International) and their results are acknowledged by many employers and institutions. They, for example, facilitate admission to universities, open the way to variety of scholarships, etc. But do they genuinely reflect the actual level of students’ proficiency? To answer this question, the authors has analyzed the structure and content of HSK and HSKK as well as their theoretical basis; they also tried to relate the Chinese examinations to the CEFR (2001). On the basis of their research, the authors point to the difficulties that Polish learners encounter when taking these examinations.
CERTYFIKATOWE TESTY Z JĘZYKA POLSKIEGO I ANGIELSKIEGO NA POZIOMIE C2 W UJĘCIU PORÓWNAWCZYM
Authors: Banach Małgorzata
Published: October 2019

The amendment to the Polish Language Act in 2015 has resulted in significant changes in the system of the state certificate examinations in Polish as a foreign language. One of the changes is a revised format of the certificate examination at C2 level. The author begins by briefly presenting the recent revisions to the test. The Polish examination is then compared with its English equivalent: C2 Proficiency, a renowned British test which has undergone numerous changes since its first administration in 1913. The comparative analysis is focused on the structure of both examinations and their parts, task types that are used and skills that are tested. Through showing similarities and differences between the analyzed language proficiency tests the author reflects on practical implications of various choices made by experts who are responsible for test design and development.
B1 I CO DALEJ? O KONIECZNOŚCI PRZYGOTOWANIA PROGRAMU NAUCZANIA JĘZYKA POLSKIEGO JAKO OBCEGO DLA CELÓW AKADEMICKICH
Authors: Jasińska Agnieszka
Published: October 2019

For the past several years we have been observing a substantial growth of interest in studies in Poland among foreign students, particular those from the East. The required level of language proficiency for Polish universities is B1 which is not difficult to achieve in a year. It is, however, by no means sufficient to participate in university classes, to follow academic discourse, to write papers or prepare for exams. This article presents the results of a research study conducted among academic lecturers and Polish language instructors teaching preparatory classes on the lacks and needs of foreign students. It also presents core demands regarding teaching Polish as a foreign language for academic purposes.
Second language English listeners’ relative processing of coherence-based and frequency-based formulas: A corpus-based study
Authors: Yeldham Michael
Published: October 2019

This study investigated L2 English listeners’ processing of formulas, in terms of the impact of two different factors inherent in these formulas. One was the formulas’ level of coherence and the other was the formulas’ level of frequency. High-coherence formulas are considered to have specialized meanings, while high-frequency formulas are considered to be less specialized in meaning, commonly being composed of relatively simple words that often co-occur in speech. In previous research, in an academic context, Ellis, Simpson-Vlach and Maynard (2008. Formulaic language in native and second-language speakers: Psycholinguistics, corpus linguistics, and TESOL. TESOL Quarterly 41. 375–396. doi:10.1002/j.1545-7249.2008.tb00137.x) had found that a high level of coherence was the main factor facilitating L1 users’ receptive processing of formulas, while a high level of frequency was the main factor facilitating advanced L2 users’ receptive processing of formulas. Ellis, Simpson-Vlach and Maynard (2008. Formulaic language in native and second-language speakers: Psycholinguistics, corpus linguistics, and TESOL. TESOL Quarterly 41. 375–396. doi:10.1002/j.1545-7249.2008.tb00137.x), from a usage-based perspective, attributed these differences mainly to the greater length of time the L1 users had spent in learning formulas. Consequently, the current study investigated whether these processing differences between the two user groups in an academic context (seen as a possible developmental trend) would be apparent between proficient and less-proficient L2 listeners in a relatively less-challenging, general English environment. The study was considered important for possibly signaling the types of aural receptive formulas to foreground by L2 general English instructors and materials designers. The research examined two groups of L2 learners, one advanced and the other intermediate level, while they listened to four texts. A paused transcription technique elicited the listeners’ identification of targeted segments from the texts, many of which were classified through corpus analysis as containing more/less-coherent formulas or more/less-frequent formulas. Examination of how these formula types were processed by both proficiency groups, however, did not find major differences between the groups in their processing of the different formula types, and thus little evidence of a possible formula developmental trend.
Development and evaluation of an element-tagged immunoassay coupled with inductively coupled plasma mass spectrometry detection: can we apply the new assay in the clinical laboratory?
Authors: Jiang Wencan , Sun Gongwei , Wen Xinyu , Men Shasha , Cui Wenbin , Jing Miao , Jia Xingwang , Hu Zhian , Pu Danna , Zhang Sichun , Yuan Xiaozhou , Liu Xiaoting , Zhang Xinrong , Wang Chengbin
Published: October 2019

Introduction

Element-tagged immunoassay coupled with inductively coupled plasma-mass spectrometry (ICP-MS) detection has the potential to revolutionize immunoassay analysis in clinical detection; however, a systematic evaluation with the standard guidelines of the assay is needed to ensure its performance meets the requirements of the clinical laboratory.

Methods

Carcinoembryonic antigen (CEA) was chosen for analysis using the proposed method. A systematic evaluation of the proposed assay was carried out according to the Clinical and Laboratory Standards Institute (CLSI). The 469 clinical samples were analyzed using the new method and compared with the electrochemiluminescent immunoassay (ECLIA) method.

Results

The measurement range of the assay was 1–900 ng/mL, with a detection limit of 0.83 ng/mL. The inter-assay and intra-assay imprecision were 4.67% and 5.38% with high concentration samples, and 9.27% and 17.64% with low concentration samples, respectively. The cross-reactivity (%) for different antigens was less than 0.05%, and the recovery was between 94% and 108%. Percentage deviation of all the dilutions was less than 12.5% during linearity estimation. The interference bias caused by different substances was less than 10%. The reference interval of the assay was 0–4.442 ng/mL. Comparison with the commercial ECLIA method for clinical sample detection, the proposed method showed a correlation of 0.9878 and no significant differences between the methods were observed (p = 0.6666).

Conclusions

The ICP-MS based immunoassay was successfully developed, and the analytical performance of the assay met the requirements of the CLSI, which fully proved the clinical transferability and application of the new method.
Deformation of rotating two-layer curved composite beams
Authors: Ecsedi István , Lengyel Ákos József
Published: October 2019

An analytical solution is presented for the determination of the deformation of rotating two-layer composite beams. The direction of axis of rotation is vertical and the speed of rotation is constant. The axis of rotation is in the plane of symmetry of curved beam. The source of the in-plane deformation is the stationary rotation of the curved beam. The plane of the curvature is the symmetry plane of the curved beam for its material, geometrical and supporting properties. Assumed form of the displacement field meets the prescriptions of the classical Euler-Bernoulli beam theory. Examples illustrate the applications of the presented analytical solution.
Quantum (q, h)-Bézier surfaces based on bivariate (q, h)-blossoming
Authors: Jegdić Ilija , Simeonov Plamen , Zafiris Vasilis
Published: October 2019

We introduce the (q, h)-blossom of bivariate polynomials, and we define the bivariate (q, h)-Bernstein polynomials and (q, h)-Bézier surfaces on rectangular domains using the tensor product. Using the (q, h)-blossom, we construct recursive evaluation algorithms for (q, h)-Bézier surfaces and we derive a dual functional property, a Marsden identity, and a number of other properties for bivariate (q, h)-Bernstein polynomials and (q, h)-Bézier surfaces. We develop a subdivision algorithm for (q, h)-Bézier surfaces with a geometric rate of convergence. Recursive evaluation algorithms for quantum (q, h)-partial derivatives of bivariate polynomials are also derived.
Ulam-Hyers stability of a parabolic partial differential equation
Authors: Marian Daniela , Ciplea Sorina Anamaria , Lungu Nicolaie
Published: October 2019

The goal of this paper is to give an Ulam-Hyers stability result for a parabolic partial differential equation. Here we present two types of Ulam stability: Ulam-Hyers stability and generalized Ulam-Hyers-Rassias stability. Some examples are given, one of them being the Black-Scholes equation.
Photonic Components for Signal Generation and Distribution for Large Aperture Radar in Autonomous Driving
Authors: Preussler Stefan , Schwartau Fabian , Schoebel Joerg , Schneider Thomas
Published: October 2019

Fully autonomous driving, even under bad weather conditions, requires use of multiple sensor systems including radar imaging. Microwave photonics, especially the optical generation and distribution of radar signals, can overcome many of the electronic disadvantages. This article will give an overview about several photonic components and how they could be incorporated into a photonic synchronized radar system, where all the complexity is shifted to a central station. A first proof-of-concept radar experiment with of the shelf telecommunication equipment shows an angular resolution of 1.1°. Furthermore an overview about possible photonic electronic integration is given, leading to comprising low complexity transmitter and receiver chips.
Dynamical Analysis of a Fractional-Order Hantavirus Infection Model
Authors: Moustafa Mahmoud , Hafiz Mohd Mohd , Izani Ismail Ahmad , Aini Abdullah Farah
Published: October 2019

This paper considers a Hantavirus infection model consisting of a system of fractional-order ordinary differential equations with logistic growth. The fractional-order model describes the spread of Hantavirus infection in a system consisting of a population of susceptible and infected mice. The existence, uniqueness, non-negativity and boundedness of the solutions are established. In addition, the local and global asymptotic stability of the equilibrium points of the fractional order system and the basic reproduction number are studied. The impact of basic reproduction number and carrying capacity on the stability of the fractional order system are also theoretically and numerically investigated.
“Leaving No One Behind” as a Site of Contestation and Reinterpretation
Authors: Fukuda-Parr Sakiko , Smaavik Hegstad Thea
Published: October 2019

One of the most important elements of the 2030 Agenda and the SDGs is the strong commitment to inclusive development, and “leaving no one behind” has emerged as a central theme of the agenda. How did this consensus come about? And what does this term mean and how is it being interpreted? This matters because SDGs shift international norms. Global goals exert influence on policy and action of governments and stakeholders in development operates through discourse. So the language used in formulating the UN Agenda is a terrain of active contestation. This paper aims to explain the politics that led to this term as a core theme. It argues that LNOB was promoted to frame the SDG inequality agenda as inclusive development, focusing on the exclusion of marginalized and vulnerable groups from social opportunities, deflecting attention from the core issues of distribution of income and wealth, and the challenge of “extreme inequality.” The term is adequately vague so as to accommodate wide ranging interpretations. Through a content analysis of LNOB in 43 VNRs, the paper finds that the majority of country strategies identify LNOB as priority to the very poor, and identify it with a strategy for social protection. This narrow interpretation does not respond to the ambition of the 2030 Agenda for transformative change, and the principles of human rights approaches laid out.
Logic Salience in Ideologically-torn Nonprofit Hybrids
Authors: Jönsson Jayne
Published: October 2019

There is a well-documented tension in many nonprofits – particularly those seeking government contracts or working in areas that compete with the private sector – between the institutional logics of business-market and nonprofit-mission. This paper presents a case study of a century old Swedish nonprofit. It suggests that in the presence of competing hybrid logics, organizational actors respond according to the logic to which they are drawn ideologically. Logic salience as a concept is proposed and its three categories are identified to delineate which type and degree of salience individuals hold towards market logic, mission logic, or towards both. The findings indicate that logic salience can enable or constrain any of the hybrid goals and can provide some explanation as to how or why certain organizational responses that do not represent the collective come about as organizations are wedged between competing logics. Considering the increasing role of nonprofits in the delivery of public services, relevance to research and policy is also highlighted.
What Is Experience? Foucauldian Perspectives
Authors: Tirkkonen Sanna
Published: October 2019

Michel Foucault’s (1926–1984) thought is widely used in the humanities and social sciences for investigating experiences of madness, illness, marginalization and social conflicts. However, the meaning of the word “experience” is not always clearly defined, and the French word expérience has a whole variety of meanings. In this article I explicate Foucault’s most relevant concepts of experience and their theoretical functions. He refers to experience throughout his career, especially in his early texts on existential psychiatry from the 1950s and 1960s and in his late work from the 1980s. Texts such as Mental Illness and Psychology and Dire vrai sur soi-même have received less attention than Foucault’s most famous books, but they show that references to experience form significant theoretical and thematic links between his earlier investigations of mental distress and his late work on ethics. When Foucault reorganizes his work in the 1980s, he looks back to his early work in his search for a new concept of experience. I argue that in these contexts, experience cannot be understood as an outcome of activity that organizes perceptions and leads to objective knowledge, but experiences are not defined as events produced by discourses, either. I demonstrate in this article how Foucault uses the concept of experience to structure his research on ethical subjectivity and cultural practices of care. At the same time the article questions some standard interpretations of his work.
Toward a Systematic, Rights-Based Moral Theory
Authors: White Alan
Published: October 2019

The structural-systematic philosophy requires a moral theory. This essay seeks to determine whether either of two recent works, Joshua Greene’s Moral Tribes and Michael Tomasello’s A Natural History of Human Morality, should influence that theory. It first argues that Greene’s fails to make its case for utilitarianism over deontology. It then argues that Tomasello’s thesis that early humans developed moralities of sympathy and fairness, particularly when taken in conjunction with aspects of Alan Gewirth’s moral theory, fits well with the moral theory envisaged by extant works on the structural-systematic philosophy. The envisaged theory maintains the objectivity of human rights.
Características sociodemográficas e clínicas de pacientes com o vírus da imunodeficiência humana
Authors: Martins Wesley Romário Dias , Silva Andréa Pereira da , Silva Fabiano de Araujo , Sousa Jayra Adrianna da Silva , Silva Joélio Pereira da , Silva Maria Luzinete Rodrigues da
Published: October 2019

Objetivo: descrever as características sociodemográficas e clínicas de pacientes diagnosticados com o vírus da imunodeficiência humana. Métodos: estudo descritivo e documental, desenvolvido a partir das informações sociodemográficas e clínicas contidas nas fichas de identificação de 33 pacientes diagnosticados com o vírus da imunodeficiência humana. Os dados foram analisados por meio do programa Statistical Package for the Social Sciences 18 para o cálculo das medidas estatísticas e associação entre variáveis. Resultados: em relação às características dos pacientes, a média de idade foi de 42 anos, variando entre 20 e 64 anos, 54,5% mulheres, casados e com baixa escolaridade, 84,8% heterossexuais e que se expuseram ao vírus por meio de relação sexual (p=0,495). Conclusão: percebeu-se que os pacientes com a infecção foram mulheres, jovens, com baixo nível de instrução e com exposição ao vírus pelo contato sexual e multiparcerias desprotegidas.
Conhecimento de enfermeiros de hospital universitário sobre bactérias multirresistentes
Authors: Rocha Maristela Yoshie Yamaji Okagawa , Lima Jemima Franco dos Santos , Kuzma Solena , Pontes Letícia , Pasquini Ricardo
Published: October 2019

Objetivo: identificar o conhecimento de enfermeiros de hospital de ensino universitário sobre bactérias multirresistentes. Métodos: estudo transversal e prospectivo, com participação de 109 enfermeiros. Coleta de dados por meio de questionário com questões abertas e fechadas. A análise estatística, seu deu por meio do programa Statistical Package for the Social Sciences. Resultados: 67,0% dos participantes consideraram o conhecimento adquirido na graduação relativo a bactérias multirresistentes insuficiente para o enfrentamento destas, com predomínio dos formados anterior ao ano de 2005; do processo de transmissão, predominaram os profissionais mais jovens. Conclusão: o conhecimento sobre bactérias multirresistentes foi maior entre profissionais mais jovens, de formação mais recente, com iniciativa individual para expandir o conhecimento sobre o tema e participação em treinamentos em serviço. O Serviço de Controle de Infecção Hospitalar foi a principal fonte provedora de conhecimentos para os enfermeiros participantes do estudo.
Teses e dissertações da enfermagem brasileira sobre a saúde da mulher no sistema prisional
Authors: Medeiros Anderson Brito de , Oliveira Lannuzya Verrissímo e , Silva Glauber Weder dos Santos , Lopes Thaís Gabriel Rosental , Carvalho Jovanka Bittencourt Leite de , Miranda Francisco Arnoldo Nunes de
Published: October 2019

Objetivo: caracterizar a produção brasileira de teses e dissertações em enfermagem sobre a saúde de mulheres no sistema prisional. Métodos: estudo bibliométrico, a partir do panorama da produção científica, no âmbito da Pós-Graduação em Enfermagem brasileira, com coleta de dados no Catálogo de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Resultados: 11 documentos fizeram parte da amostra. A maioria destes foi realizada durante mestrado (63,6%), com predominância nas Regiões Nordeste (63,6%), Sudeste (18,1%) e Centro-oeste (18,1%). Quanto às temáticas mais exploradas, as relações de mulheres/mães com os filhos apresentaram maior proporção (54,5%). Predominaram os estudos qualitativos (45,4%), com desenhos descritivos (36,3%). Conclusão: teses e dissertações brasileiras de enfermagem sobre a saúde da mulher no sistema prisional constituíram-se por estudos qualitativos, provenientes das regiões Nordeste, Sudeste e Centro-oeste, as quais apresentaram lacuna na produção do conhecimento de enfermagem.
Longitudinal analysis of quality of life in patients treated for differentiated thyroid cancer
Authors: van Velsen Evert F S , Massolt Elske T , Heersema Hélène , Kam Boen L R , van Ginhoven Tessa M , Visser W Edward , Peeters Robin P
Published: October 2019

Objective

Earlier cross-sectional studies showed that patients with differentiated thyroid cancer (DTC) have a significant reduction of quality of life (QoL) compared to controls. However, recent longitudinal studies showed mixed results and had relative short follow-up or lacked knowledge about QoL before initial surgery. Therefore, we initiated a longitudinal study to assess changes of QoL in patients undergoing treatment for DTC.

Methods

We prospectively included patients, aged 18–80 years, who were treated for DTC at a Dutch university hospital. Using questionnaires, QoL was assessed before surgery, just before radioiodine (RAI) therapy, and regularly during follow-up. Repeated measurement analysis was used to assess changes of QoL over time, and we explored the influence of different characteristics on QoL.

Results

Longitudinal QoL assessments were available in 185 patients (mean age 47 years; 71% women). All patients were treated according to the Dutch guidelines with total thyroidectomy followed by RAI (83% after thyroid hormone withdrawal). Median time between baseline and final questionnaire was 31 months, and patients completed a median of three questionnaires. QoL at baseline was lower than that in the general population, developed non-linear over time, was lowest around RAI therapy, and recovered over time. Females, younger patients, and patients with persistent hypoparathyroidism had lower QoL scores.

Conclusions

In a population of DTC patients, QoL before initial therapy is already lower than that in the general population. Thereafter, QoL develops non-linearly over time in general, with the lowest QoL around RAI therapy, while 2 to 3 years later, it approximates baseline values.
Activity and safety of temozolomide in advanced adrenocortical carcinoma patients
Authors: Cosentini Deborah , Badalamenti Giuseppe , Grisanti Salvatore , Basile Vittoria , Rapa Ida , Cerri Sara , Spallanzani Andrea , Perotti Paola , Musso Emanuela , Laganà Marta , Ferrari Vittorio D , Luppi Gabriele , Dalla Volta Alberto , Incorvaia Lorena , Sigala Sandra , Russo Antonio , Volante Marco , Terzolo Massimo , Berruti Alfredo
Published: October 2019

Objective

Temozolomide has shown a significant anti-proliferative activity on adrenocortical cancer (ACC) cells in vitro.

Design

On the basis of these results the drug was prescribed as second/third line in advanced metastatic ACC patients in four referral centers in Italy.

Methods

We retrospectively collected anagraphic, clinical and pathological data of patients with advanced ACC with disease progression to standard chemotherapy plus mitotane who were treated with temozolomide at the dose of 200 mg/m2/die given for 5 consecutive days every 28 days. The primary endpoint was the disease control rate, defined as objective response or disease stabilization after 3 months. Secondary endpoints were overall survival (OS), progression-free survival (PFS) and drug safety.

Results

Twenty-eight patients have been included in the study. Ten patients (35.8%, 95% CI: 17.8–53.8) obtained a disease control from temozolomide treatment. In particular, 1 patient had a complete response, 5 patients a partial response and 4 patients stable disease. Median PFS was 3.5 months and median OS was 7.2 months. Disease response was more frequently observed in patients with methylation of O6-methylguanine-DNA methyltransferase (MGMT) gene. Temozolomide therapy was well tolerated and most toxicities were limited to grade G1–2 according to WHO criteria.

Conclusion

Temozolomide was found active in the management of advanced ACC patients. The disease control rate obtained, however, was short-lived and the prognosis of treated patients was poor.