bluuebunny/crossref_metadata_2025 huggingface dataset:
Leistungsthematischer Gehalt von Schulbüchern und Bildungsleistung in der Grundschule
Authors: Engeser Stefan , Euen Benjamin , Bos Wilfried
Published: May 2015

Auf Grundlage korrelativer und experimenteller Arbeiten haben wir erwartet, dass der leistungsthematische Gehalt von Grundschulbüchern einen positiven Zusammenhang mit der Bildungsleistung in der Grundschule aufweist. Um die Erwartung zu überprüfen, haben wir im Rahmen der internationalen Schulleistungsuntersuchung TIMSS und PIRLS die Mathematik- und Deutschlehrkräfte nach den von ihnen genutzten Schulbüchern gefragt und den leistungsthematischen Gehalt der genannten Schulbücher analysiert. Der gefundene positive Zusammenhang des leistungsthematischen Gehaltes mit der Bildungsleistung in Kompetenztests für den Bereich Mathematik bestätigte unsere Annahme, wobei der Effekt schwach ausgeprägt war. Für Deutsch zeigte sich ebenfalls ein positiver Zusammenhang, der jedoch nicht statistisch abgesichert werden konnte. Insgesamt können die Ergebnisse als ein weiterer Hinweis gewertet werden, dass der leistungsthematische Gehalt eine Einflussvariable der Bildungsleistung ist. Analysen über den leistungsthematischen Gehalt hinaus zeigten, dass die Verwendung bestimmter Mathematikbücher mit höherer bzw. niedrigerer Bildungsleistung einherging.
miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2
Authors: An Y , Zhang Z , Shang Y , Jiang X , Dong J , Yu P , Nie Y , Zhao Q
Published: May 2015

Chemotherapy is an important treatment modality for gastric cancer (GC); however, it usually fails because of drug resistance, especially multidrug resistance (MDR). Previously, we found a novel subset of MDR-associated microRNAs (miRNAs) through high-throughput functional screening. In this report, we investigated the exact roles and mechanisms of miR-23b-3p in the MDR of GC. Using gain or loss-of-function in in vitro and in vivo experiments, we found that overexpression of miR-23b-3p reversed cancer cell resistance to multiple chemotherapeutics in vitro and sensitize tumors to chemotherapy in vivo. Reporter gene assay and western blot analysis showed that ATG12 and HMGB2 were the direct targets of miR-23b-3p. Meanwhile, ATG12 and HMGB2 were positively associated with the occurrence of autophagy. Reducing the expression of these target genes by siRNA or inhibition of autophagy both sensitized GC cells to chemotherapy. These findings suggest that a miR-23b-3p/ATG12/HMGB2/autophagy-regulatory loop has a critical role in MDR in GC. In addition, miR-23b-3p could be used as a prognostic factor for overall survival in GC. In conclusion, our data demonstrated that miR-23b-3p inhibited autophagy mediated by ATG12 and HMGB2 and sensitized GC cells to chemotherapy, and suggested the potential application of miR-23b-3p in drug resistance prediction and treatment.
Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism
Authors: Ugrankar Rupali , Berglund Eric , Akdemir Fatih , Tran Christopher , Kim Min Soo , Noh Jungsik , Schneider Rebekka , Ebert Benjamin , Graff Jonathan M.
Published: May 2015

Circulating carbohydrates are an essential energy source, perturbations in which are pathognomonic of various diseases, diabetes being the most prevalent. Yet many of the genes underlying diabetes and its characteristic hyperglycaemia remain elusive. Here we use physiological and genetic interrogations in D. melanogaster to uncover the ‘glucome’, the complete set of genes involved in glucose regulation in flies. Partial genomic screens of ∼1,000 genes yield ∼160 hyperglycaemia ‘flyabetes’ candidates that we classify using fat body- and muscle-specific knockdown and biochemical assays. The results highlight the minor glucose fraction as a physiological indicator of metabolism in Drosophila. The hits uncovered in our screen may have conserved functions in mammalian glucose homeostasis, as heterozygous and homozygous mutants of Ck1alpha in the murine adipose lineage, develop diabetes. Our findings demonstrate that glucose has a role in fly biology and that genetic screenings carried out in flies may increase our understanding of mammalian pathophysiology.
Microscopic dynamics of synchronization in driven colloids
Authors: Juniper Michael P.N. , Straube Arthur V. , Besseling Rut , Aarts Dirk G.A.L. , Dullens Roel P.A.
Published: May 2015

Synchronization of coupled oscillators has been scrutinized for over three centuries, from Huygens’ pendulum clocks to physiological rhythms. One such synchronization phenomenon, dynamic mode locking, occurs when naturally oscillating processes are driven by an externally imposed modulation. Typically only averaged or integrated properties are accessible, leaving underlying mechanisms unseen. Here, we visualize the microscopic dynamics underlying mode locking in a colloidal model system, by using particle trajectories to produce phase portraits. Furthermore, we use this approach to examine the enhancement of mode locking in a flexible chain of magnetically coupled particles, which we ascribe to breathing modes caused by mode-locked density waves. Finally, we demonstrate that an emergent density wave in a static colloidal chain mode locks as a quasi-particle, with microscopic dynamics analogous to those seen for a single particle. Our results indicate that understanding the intricate link between emergent behaviour and microscopic dynamics is key to controlling synchronization.
Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease
Authors: De Jesús-Cortés Héctor , Miller Adam D , Britt Jeremiah K , DeMarco Anthony J , De Jesús-Cortés Mayralis , Stuebing Emily , Naidoo Jacinth , Vázquez-Rosa Edwin , Morlock Lorraine , Williams Noelle S , Ready Joseph M , Narayanan Nandakumar S , Pieper Andrew A
Published: May 2015

Background:

There are currently no therapeutic options for patients with Parkinson's disease that prevent or slow the death of dopaminergic neurons. We have recently identified the novel P7C3 class of neuroprotective molecules that blocks neuron cell death.

AIMS:

The aim of this study was to determine whether treatment with highly active members of the P7C3 series blocks dopaminergic neuron cell death and associated behavioral and neurochemical deficits in the rat 6-hydroxydopamine (6-OHDA) model of Parkinson's disease.

Methods:

After unilateral injection of 6-OHDA into the median forebrain bundle, rats were assessed for behavioral function in the open field, cylinder test, and amphetamine-induced circling test. Thereafter, their brains were subjected to neurochemical and immunohistochemical analysis of dopaminergic neuron survival. Analysis was conducted as a function of treatment with P7C3 compounds, with administration initiated either before or after 6-OHDA exposure.

Results:

Animals administered P7C3-A20 or P7C3-S243, two of the most advanced agents in the P7C3 series of neuroprotective compounds, both before and after 6-OHDA exposure showed evidence of protective efficacy in all measures. When P7C3-S243 administration was initiated after 6-OHDA exposure, rats also showed protective efficacy in all measures, which included blocking dopaminergic neuron cell death in ipsilateral substantia nigra pars compacta, preservation of dopamine and its metabolites in ipsilateral striatum, and preservation of normal motor behavior.

Conclusions:

The P7C3 series of compounds may form the basis for developing new therapeutic agents for slowing or preventing progression of Parkinson's disease.
Physical Sensing of Surface Properties by Microswimmers – Directing Bacterial Motion via Wall Slip
Authors: Hu Jinglei , Wysocki Adam , Winkler Roland G. , Gompper Gerhard
Published: May 2015

Bacteria such asEscherichia coliswim along circular trajectories adjacent to surfaces. Thereby, the orientation (clockwise, counterclockwise) and the curvature depend on the surface properties. We employ mesoscale hydrodynamic simulations of a mechano-elastic model ofE. coli, with a spherocylindrical body propelled by a bundle of rotating helical flagella, to study quantitatively the curvature of the appearing circular trajectories. We demonstrate that the cell is sensitive to nanoscale changes in the surface slip length. The results are employed to propose a novel approach to directing bacterial motion on striped surfaces with different slip lengths, which implies a transformation of the circular motion into a snaking motion along the stripe boundaries. The feasibility of this approach is demonstrated by a simulation of active Brownian rods, which also reveals a dependence of directional motion on the stripe width.
A terpenoid phytoalexin plays a role in basal defense of Nicotiana benthamiana against Potato virus X
Authors: Li Ran , Tee Chuan-Sia , Jiang Yu-Lin , Jiang Xi-Yuan , Venkatesh Prasanna Nori , Sarojam Rajani , Ye Jian
Published: May 2015

Terpenoid phytoalexins function as defense compound against a broad spectrum of pathogens and pests in the plant kingdom. However, the role of phytoalexin in antiviral defense is still elusive. In this study, we identified the biosynthesis pathway of a sesquiterpenoid phytoalexin, capsidiol 3-acetate as an antiviral response against RNA virus Potato Virus X (PVX) in Nicotiana benthamiana. NbTPS1 and NbEAH genes were found strongly induced by PVX-infection. Enzymatic activity and genetic evidence indicated that both genes were involved in the PVX-induced biosynthesis of capsidiol 3-acetate. NbTPS1- or NbEAH-silenced plant was more susceptible to PVX. The accumulation of capsidiol 3-acetate in PVX-infected plant was partially regulated by jasmonic acid signaling receptor COI1. These findings provide an insight into a novel mechanism of how plant uses the basal arsenal machinery to mount a fight against virus attack even in susceptible species.
JBP485 promotes tear and mucin secretion in ocular surface epithelia
Authors: Nakamura Takahiro , Hata Yuiko , Nagata Maho , Yokoi Norihiko , Yamaguchi Shumpei , Kaku Taiichi , Kinoshita Shigeru
Published: May 2015

Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential for maintaining the homeostasis of the wet ocular surface. Since there are a limited number of clinical options for the treatment of DES, additional novel treatments are needed to improve the clinical results. In this study, we found that placental extract-derived dipeptide (JBP485) clearly promoted the expression and secretion of gel-forming mucin 5ac (Muc5ac) in rabbit conjunctival epithelium. JBP485 also elevated the expression level of cell surface-associated mucins (Muc1/4/16) in rabbit corneal epithelium. The Schirmer tear test results indicated that JBP485 induced tear secretion in the rabbit model. Moreover, JBP485 clinically improved corneal epithelial damage in a mouse dry eye model. Thus, our data indicate that JBP485 efficiently promoted mucin and aqueous tear secretion in rabbit ocular surface epithelium and has the potential to be used as a novel treatment for DES.
Reliable Attention Network Scores and Mutually Inhibited Inter-network Relationships Revealed by Mixed Design and Non-orthogonal Method
Authors: Wang Yi-Feng , Jing Xiu-Juan , Liu Feng , Li Mei-Ling , Long Zhi-Liang , Yan Jin H. , Chen Hua-Fu
Published: May 2015

The attention system can be divided into alerting, orienting and executive control networks. The efficiency and independence of attention networks have been widely tested with the attention network test (ANT) and its revised versions. However, many studies have failed to find effects of attention network scores (ANSs) and inter-network relationships (INRs). Moreover, the low reliability of ANSs can not meet the demands of theoretical and empirical investigations. Two methodological factors (the inter-trial influence in the event-related design and the inter-network interference in orthogonal contrast) may be responsible for the unreliability of ANT. In this study, we combined the mixed design and non-orthogonal method to explore ANSs and directional INRs. With a small number of trials, we obtained reliable and independent ANSs (split-half reliability of alerting: 0.684; orienting: 0.588; and executive control: 0.616), suggesting an individual and specific attention system. Furthermore, mutual inhibition was observed when two networks were operated simultaneously, indicating a differentiated but integrated attention system. Overall, the reliable and individual specific ANSs and mutually inhibited INRs provide novel insight into the understanding of the developmental, physiological and pathological mechanisms of attention networks and can benefit future experimental and clinical investigations of attention using ANT.
Indian Hedgehog signaling pathway members are associated with magnetic resonance imaging manifestations and pathological scores in lumbar facet joint osteoarthritis
Authors: Shuang Feng , Zhou Ying , Hou Shu-Xun , Zhu Jia-Liang , Liu Yan , Zhang Chun-Li , Tang Jia-Guang
Published: May 2015

Indian Hedgehog (HH) has been shown to be involved in osteoarthritis (OA) in articular joints, where there is evidence that Indian HH blockade could ameliorate OA. It seems to play a prominent role in development of the intervertebral disc (IVD) and in postnatal maintenance. There is little work on IHH in the IVD. Hence the aim of the current study was to investigate the role of Indian Hedgehog in the pathology of facet joint (FJ) OA. 24 patients diagnosed with lumbar intervertebral disk herniation or degenerative spinal stenosis were included. Preoperative magnetic resonance imaging (MRI) and Osteoarthritis Research Society International (OARSI) histopathology grading system was correlated to the mRNA levels of GLI1, PTCH1 and HHIP in the FJs. The Weishaupt grading and OARSI scores showed high positive correlation (r = 0.894) (P < 0.01). MRI Weishaupt grades showed positive correlation with GLI1 (r = 0.491), PTCH1 (r = 0.444) and HHIP (r = 0.654) mRNA levels (P < 0.05 in each case). OARSI scores were also positively correlated with GLI1 (r = 0. 646), PTCH1 (r = 0. 518) and HHIP (r = 0.762) mRNA levels (P < 0.01 in each case). Cumulatively our findings indicate that Indian HH signaling is increased in OA and is perhaps a key component in OA pathogenesis and progression.
Effect of uniaxial strain on the site occupancy of hydrogen in vanadium from density-functional calculations
Authors: Johansson Robert , Ahuja Rajeev , Eriksson Olle , Hjörvarsson Björgvin , Scheicher Ralph H.
Published: May 2015

We investigate the influence of uniaxial strain on the site occupancy of hydrogen in vanadium, using density functional theory. The site occupancy is found to be strongly influenced by the strain state of the lattice. The results provide the conceptual framework for the atomistic description of the observed hysteresis in the "Equation missing"to "Equation missing"phase transition in bulk, as well as the preferred octahedral occupancy of hydrogen in strained V layers.
The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage
Authors: Guan Pei-Pei , Guo Jing-Wen , Yu Xin , Wang Yue , Wang Tao , Konstantopoulos Konstantinos , Wang Zhan-You , Wang Pu
Published: May 2015

MMP-1 expression is detected in fluid shear stress (20 dyn/cm2)-activated and osteoarthritic human chondrocytes, however, the precise mechanisms underlying shear-induced MMP-1 synthesis remain unknown. Using primary chondrocytes and T/C-28a2 chondrocytic cells as model systems, we report that prolonged application of high fluid shear to human chondrocytes induced the synthesis of cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β) and fibroblast growth factor-2 (FGF-2), which led to a marked increase in MMP-1 expression. IL-1β, COX-2-dependent PGE2 activated the PI3-K/AKT and p38 signaling pathways, which were in turn responsible for MMP-1 synthesis via NF-κB- and c-Jun-transactivating pathways. Prolonged shear stress exposure (>12 h) induced 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) synthesis. Although 15d-PGJ2 suppressed PI3-K/AKT and p38 signaling pathways, it stimulated MMP-1 expression via activating heme oxygenase 1 (HO-1). The critical role of COX-2 in regulating MMP-1 expression in articular cartilage in vivo was demonstrated using COX-2+/− transgenic mice in the absence or presence of rofecoxib oral administration. These findings provide novel insights for developing therapeutic strategies to combat OA.
Is impaired response inhibition independent of symptom dimensions in obsessive-compulsive disorder? Evidence from ERPs
Authors: Lei Hui , Zhu Xiongzhao , Fan Jie , Dong Jiaojiao , Zhou Cheng , Zhang Xiaocui , Zhong Mingtian
Published: May 2015

Impaired response inhibition has been consistently reported in patients diagnosed with obsessive-compulsive disorder (OCD). This clinically heterogeneous disorder is characterized by several symptom dimensions that may have distinct, but partially overlapping, neural correlates. The present study examined whether alterations in response inhibition may be related to symptom severity and symptom dimensions. Event-related potentials (ERPs) were recorded in a group of 42 medication-free OCD patients as well as 42 healthy controls during a stop-signal task. Symptom dimension scores were obtained using the Yale-Brown Obsessive Compulsive Scale symptom checklist. OCD patients showed longer stop-signal reaction times (SSRT, p < 0.01) and larger stop-N2 amplitudes (p < 0.01) compared to healthy controls. Neither the longer SSRT nor the larger stop-N2 scores were significantly correlated with symptom severity or present or lifetime OCD symptoms in OCD patients. These results indicate that deficient response inhibition is a common occurrence in OCD patients that is independent of global symptom severity and symptom dimensions. These data support the notion that impaired response inhibition may be a general attribute of patients with OCD.
Opening of triangular hole in triangular-shaped chemical vapor deposited hexagonal boron nitride crystal
Authors: Sharma Subash , Kalita Golap , Vishwakarma Riteshkumar , Zulkifli Zurita , Tanemura Masaki
Published: May 2015

In-plane heterostructure of monolayer hexagonal boron nitride (h-BN) and graphene is of great interest for its tunable bandgap and other unique properties. Here, we reveal a H2-induced etching process to introduce triangular hole in triangular-shaped chemical vapor deposited individual h-BN crystal. In this study, we synthesized regular triangular-shaped h-BN crystals with the sizes around 2-10 μm on Cu foil by chemical vapor deposition (CVD). The etching behavior of individual h-BN crystal was investigated by annealing at different temperature in an H2:Ar atmosphere. Annealing at 900 °C, etching of h-BN was observed from crystal edges with no visible etching at the center of individual crystals. While, annealing at a temperature ≥950 °C, highly anisotropic etching was observed, where the etched areas were equilateral triangle-shaped with same orientation as that of original h-BN crystal. The etching process and well-defined triangular hole formation can be significant platform to fabricate planar heterostructure with graphene or other two-dimensional (2D) materials.
A novel DNA sequence motif in human and mouse genomes
Authors: Zhang Shilu , Du Fang , Ji Hongkai
Published: May 2015

We report a novel DNA sequence motif in human and mouse genomes. This motif has several interesting features indicating that it is highly likely to be an unknown functional sequence element. The motif is highly enriched in promoter regions. Locations of the motif sites in the genome have strong tendency to be clustered together. Motif sites are associated with increased phylogenetic conservation as well as elevated DNase I hypersensitivity (DHS) in ENCODE cell lines. Clustered motif sites are found in promoter regions of a substantial fraction of the protein-coding genes in the genome. All together, these indicate that the motif may have important functions associated with a large number of genes.
Bioinformatical Analysis of the Sequences, Structures and Functions of Fungal Polyketide Synthase Product Template Domains
Authors: Liu Lu , Zhang Zheng , Shao Chang-Lun , Wang Jin-Lan , Bai Hong , Wang Chang-Yun
Published: May 2015

The product template (PT) domains, specifically in fungal non-reducing polyketide synthases (NR-PKSs), mediate the regioselective cyclization of polyketides dominating the final structures. However, up to date, the systematic knowledge about PT domains has been insufficient. In present study, the relationships between sequences, structures and functions of the PT domains were analyzed with 661 NR-PKS sequences. Based on the phylogenetic analysis, the PT domains were classified into prominent eight groups (I–VIII) corresponding with the representative compounds and cyclization regioselectivity (C2-C7, C4-C9 and C6-C11). Most of the cavity lining residue (CLR) sites in all groups were common, while the regional CLR site mutations resulted in the appearance of finger-like regions with different orientation. The cavity volumes and shapes, even the catalytic dyad positions of PT domains in different groups were corresponding with characteristic cyclization regioselectivity and compound sizes. The conservative residues in PT sequences were responsible for the cyclization functions and the evolution of the key residues resulted in the differentiations of cyclization functions. The above findings may help to better understand the cyclization mechanisms of PT domains and even predict the structural types of the aromatic polyketide products.
Comparison of nedaplatin-based versus cisplatin-based chemotherapy for advanced non-small cell lung cancer among East Asian populations: A meta-analysis
Authors: Liu Yun , Yu Shaorong , Liu Siwen , Cao Haixia , Ma Rong , Wu Jianzhong , Feng Jifeng
Published: May 2015

Whether nedaplatin and cisplatin are equally effective for advanced non-small cell lung cancer (NSCLC) remains uncertain. Therefore, we performed a meta-analysis of trials to compare nedaplatin-based chemotherapy with cisplatin-based chemotherapy. We conducted a literature search to identify trials that had investigated the substitution of nedaplatin for cisplatin in the treatment of advanced NSCLC. Fourteen randomized controlled trials were included. We found equivalent overall response, overall survival and survival probability (0.5-year, 1-year). Considering the toxicity profiles, nausea and vomiting were common in the cisplatin group (OR = 0.28, 95% CI = 0.20–0.40, P < 0.001), whereas severe thrombocytopenia was common in the nedaplatin group (OR = 1.68, 95% CI = 1.18–2.40, P = 0.005). A subgroup analysis of grades 1–4 nephrotoxicity showed that cisplatin-based chemotherapy resulted in more renal toxicity (OR = 0.40, 95% CI = 0.24–0.68, P = 0.001). No significant heterogeneity and publication bias were observed. Cumulative analysis found a stable time-dependent trend. Consistent results stratified by age, regimen and country were observed. Cisplatin-based chemotherapy was associated with non-inferior antitumor efficacy compared with nedaplatin-based therapy. Therefore, the toxicity profile might play an important role in choosing between cisplatin-based or nedaplatin-based regimens.
The Epidemiological Study of Coxsackievirus A6 revealing Hand, Foot and Mouth Disease Epidemic patterns in Guangdong, China
Authors: Zeng Hanri , Lu Jing , Zheng Huanying , Yi Lina , Guo Xue , Liu Leng , Rutherford Shannon , Sun Limei , Tan Xiaohua , Li Hui , Ke Changwen , Lin Jinyan
Published: May 2015

Enterovirus A71 (EVA71) and Coxsackievirus A16 (CVA16) are regarded as the two major causative pathogens in hand, foot and mouth disease (HFMD) epidemics. However, CVA6, previously largely ignored, became the predominant pathogen in China in 2013. In this study, we describe the epidemiological trendsofCVA6 during the annual HFMD outbreaks from 2008 to 2013 in Guangdong, China. The study results show that CVA6 has been one of three major causative agents of HFMD epidemics since 2009. The periodic rotation and dominance of the three pathogens, EVA71, CVA16 and CVA6, may have contributed to the continuously increasing HFMD epidemics. Moreover, phylogenetic analysis of the VP1 gene shows that major circulating CVA6 strains collected from 2009 to 2013 are distinct from the earlier strains collected before 2009. In conclusion, the discovery from this research investigating epidemiological trends of CVA6 from 2008 to 2013 explains the possible pattern of the continuous HFMD epidemic in China. The etiological change pattern also highlights the need for improvement for pathogen surveillance and vaccine strategies for HFMD control in China.
Oligonucleotide Probes for ND-FISH Analysis to Identify Rye and Wheat Chromosomes
Authors: Fu Shulan , Chen Lei , Wang Yangyang , Li Meng , Yang Zujun , Qiu Ling , Yan Benju , Ren Zhenglong , Tang Zongxiang
Published: May 2015

Genomic in situ hybridization (GISH) has been widely used to detect rye (Secale cereale L.) chromosomes in wheat (Triticum aestivum L.) introgression lines. The routine procedure of GISH using genomic DNA of rye as a probe is time-consuming and labor-intensive because of the preparation and labeling of genomic DNA of rye and denaturing of chromosomes and probes. In this study, new oligonucleotide probes Oligo-1162, Oligo-pSc200 and Oligo-pSc250 were developed. The three new probes can be used for non-denaturing fluorescence in situ hybridization (ND-FISH) assays and replace genomic DNA of rye as a probe to discriminate rye chromosomes in wheat backgrounds. In addition, previously developed oligonucleotide probes Oligo-pSc119.2-1, Oligo-pSc119.2-2, Oligo-pTa535-1, Oligo-pTa535-2, Oligo-pTa71-2, Oligo-pAWRC.1 and Oligo-CCS1 can also be used for ND-FISH of wheat and rye. These probes have provided an easier, faster and more cost-effective method for the FISH analysis of wheat and hybrids derived from wheat × rye.
Low-current field-assisted assembly of copper nanoparticles for current collectors
Authors: Liu Lehao , Choi Bong Gill , Tung Siu On , Hu Tao , Liu Yajie , Li Tiehu , Zhao Tingkai , Kotov Nicholas A.
Published: May 2015

Current collectors are essential features of batteries and many other electronic devices being responsible for efficient charge transport to active electrode materials. Three-dimensional (3D), high surface area current collectors considerably improve the performance of cathodes and anodes in batteries, but their technological implementation is impeded by the complexity of their preparation, which needs to be simple, fast, and energy efficient. Here we demonstrate that field-stimulated assembly of ∼3 nm copper nanoparticles (NPs) enables the preparation of porous Cu NP films. The use of NP dispersions enables 30× reduction of the deposition current for making functional 3D coatings. In addition to high surface area, lattice-to-lattice connectivity in the self-assembly of NPs in 3D structures enables fast charge transport. The mesoscale dimensions of out-of-plane features and the spacing between them in Cu films made by field-stimulated self-assembly of NPs provides promising morphology for current collection in lithium ion batteries (LIBs). Half-cell electrochemical models based on self-assembled films show improved specific capacity, total capacity, and cycling performance compared to traditional flat and other 3D current collectors. While integration of active electrode material into the 3D topography of the current collector needs to be improved, this study indicates that self-assembled NP films represent a viable manufacturing approach for 3D electrodes.
Capsaicin inhibits the adipogenic differentiation of bone marrow mesenchymal stem cells by regulating cell proliferation, apoptosis, oxidative and nitrosative stress
Authors: Ibrahim Muhammed , Jang Mi , Park Mina , Gobianand Kuppannan , You Seungkwon , Yeon Sung-Heom , Park Sungkwon , Kim Min Ji , Lee Hyun-Jeong
Published: May 2015

Suppression of the maturation of pre-adipocytes into adipocytes and inhibition of the differentiation of mesenchymal stem cells into adipocytes by capsaicin.
Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells
Authors: Hollywood Katherine A. , Winder Catherine L. , Dunn Warwick B. , Xu Yun , Broadhurst David , Griffiths Christopher E. M. , Goodacre Royston
Published: May 2015

GC-MS-based metabolomics illustrates the response of central metabolism metabolites upon treatment with the anti-psoriatic drug dithranol.
Nanoporous copper oxide ribbon assembly of free-standing nanoneedles as biosensors for glucose
Authors: Sun Shaodong , Sun Yuexia , Chen Anran , Zhang Xiaozhe , Yang Zhimao
Published: May 2015

Two-dimensional (2D) hierarchical nanoporous CuO ribbons were successfully synthesized by a green solution-phase route. They serve as a promising electrode material for nonenzymatic glucose detection and show high sensitivity, a low detection limit, fast amperometric response and good selectivity.
Comment on “Simple fluorescence-based detection of Cr(iii) and Cr(vi) using unmodified gold nanoparticles” by M. Elavarasi, S. A. Alex, N. Chandrasekaran and A. Mukherjee, Anal. Methods, 2014, 6, 9554
Authors: Hormozi-Nezhad M. Reza , Mohammadi J. , Bigdeli A.
Published: May 2015

This Comment is an attempt to clarify the difference between Rayleigh scattering peaks and fluorescence peaks in gold nanoparticles.
Investigation of protonated and sodiated leucine-enkephalin by hydrogen–deuterium exchange and theoretical calculations
Authors: Chen Yinjuan , Yue Lei , Li Zhenhua , Ding Xunlei , Wang Liang , Dai Xinhua , Fang Xiang , Pan Yuanjiang , Ding Chuan-Fan
Published: May 2015

Comparison of protonated and sodiated leucine-enkephalin by hydrogen–deuterium exchange mass spectrometry and theoretical calculations.
13C isotopomics of triacylglycerols using NMR with polarization transfer techniques
Authors: Merchak Noelle , Bejjani Joseph , Rizk Toufic , Silvestre Virginie , Remaud Gerald S. , Akoka Serge
Published: May 2015

A rapid and very precise method is proposed to simultaneously determine the position-specific 13C content and the metabolomic profile of triacylglycerols (isotopomics). Powerful origin tracers such as , , , and become rapidly available.
Reversible piezochromism in a molecular wine-rack
Authors: Harty Elena L. , Ha Alex R. , Warren Mark R. , Thompson Amber L. , Allan David R. , Goodwin Andrew L. , Funnell Nicholas P.
Published: May 2015

Coupling of a ‘wine-rack’ lattice motif with molecular flexibility leads to a large piezochromic response in an organic material.
Controllable synthesis of hollow mesoporous silica particles by a facile one-pot sol–gel method
Authors: Song Jing-Chuan , Xue Fei-Fei , Lu Zhong-Yuan , Sun Zhao-Yan
Published: May 2015

A simple and facile one-pot sol–gel method is proposed for the fabrication of hollow mesoporous silica particles. Both the particle size and the shell thickness can be well controlled.
N-type pyrazine and triazole-based luminogens with aggregation-enhanced emission characteristics
Authors: Chen Ming , Li Lingzhi , Nie Han , Shi Yang , Mei Ju , Wang Jian , Sun Jing Zhi , Qin Anjun , Tang Ben Zhong
Published: May 2015

N-type pyrazine and triazole-based AIEgens that could readily form red-emissive complexes with triphenylamine in the aggregate state were facilely prepared by click reactions.
Light induced E–Z isomerization in a multi-responsive organogel: elucidation from 1H NMR spectroscopy
Authors: Mondal Sanjoy , Chakraborty Priyadarshi , Bairi Partha , Chatterjee Dhruba P. , Nandi Arun K.
Published: May 2015

Light induced E–Z isomerization along imine bond in a multiresponsive organogel of anthracene attached 3,4,5-tris(dodecyloxy)benzohydrazide gelator altering morphology, fluorescence and mechanical properties is elucidated from 1H NMR spectra.
Proton conduction in Mo(vi)-based metallo-supramolecular polymers
Authors: Pandey Rakesh K. , Delwar Hossain Md. , Chakraborty Chanchal , Moriyama Satoshi , Higuchi Masayoshi
Published: May 2015

High proton conduction was observed in a Mo(vi)-based metallo-supramolecular polymer with carboxylic acids at 95%RH. The integration of OH groups into the polymer was analysed using FTIR spectroscopy and found to be crucial for the proton transport in the polymer.
Correction: Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey
Authors: Li-Yuan Bao Robert , Zhao Rong , Shi Lei
Published: May 2015

Correction for ‘Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey’ by Robert Li-Yuan Bao et al., Chem. Commun., 2015, 51, 6884–6900.
An asymmetric naphthalimide derivative for n-channel organic field-effect transistors
Authors: Wang Zongrui , Zhao Jianfeng , Dong Huanli , Qiu Ge , Zhang Qichun , Hu Wenping
Published: May 2015

A novel asymmetric naphthalimide derivative (IZ0) is synthesized and high electron mobility of 0.072 cm2V−1s−1and 0.22 cm2V−1s−1are achieved for IZ0 film and single crystal-based transistors, respectively.
Constant capacitance in nanopores of carbon monoliths
Authors: García-Gómez Alejandra , Moreno-Fernández Gelines , Lobato Belén , Centeno Teresa A.
Published: May 2015

Binder-free electrodes made of carbon monoliths with narrow micropore size distributions confirm the constant surface-capacitance in the electrolyte Et4NBF4/acetonitrile.
Two-photon polymerization microfabrication of hydrogels: an advanced 3D printing technology for tissue engineering and drug delivery
Authors: Xing Jin-Feng , Zheng Mei-Ling , Duan Xuan-Ming
Published: May 2015

Arbitrary and ultraprecise 3D hydrogels with high resolution on micro/nano scale can be produced by two-photon polymerization microfabrication as an advanced 3D printing technology.
Biomanufacturing of CdS quantum dots
Authors: Yang Zhou , Lu Li , Berard Victoria F. , He Qian , Kiely Christopher J. , Berger Bryan W. , McIntosh Steven
Published: May 2015

A strain ofStenotrophomonas maltophiliais engineered to achieve size controlled synthesis of water soluble CdS quantum dots.
Herbicidal ionic liquids based on esterquats
Authors: Pernak Juliusz , Czerniak Kamil , Niemczak Michał , Chrzanowski Łukasz , Ławniczak Łukasz , Fochtman Przemysław , Marcinkowska Katarzyna , Praczyk Tadeusz
Published: May 2015

Herbicidal ionic liquids (HILs) are candidates for novel, efficient and environmentally friendly plant protection agents.
Thermoelectric properties of nanocrystalline Cu3SbSe4 thin films deposited by a self-organized arrested precipitation technique
Authors: Ghanwat Vishvanath B. , Mali Sawanta S. , Mane Rahul M. , Patil Pramod S. , Hong Chang Kook , Bhosale Popatrao N.
Published: May 2015

Ternary Cu3SbSe4 thin films prepared by an arrested precipitation technique using non-toxic tartaric acid exhibit good thermoelectric properties.
Experimental and theoretical studies of the ancillary ligand (E)-2-((3-amino-pyridin-4-ylimino)-methyl)-4,6-di-tert-butylphenol in the rhenium(i) core
Authors: Carreño Alexander , Gacitua Manuel , Schott Eduardo , Zarate Ximena , Manriquez Juan Manuel , Preite Marcelo , Ladeira Sonia , Castel Annie , Pizarro Nancy , Vega Andrés , Chavez Ivonne , Arratia-Perez Ramiro
Published: May 2015

The Re(CO)3(deeb)L+ complex with an ancillary ligand that presents electron withdrawing effects was synthesized and studied by experimental and computational methods.
Enhanced sunlight photocatalytic activity of Ag3PO4 decorated novel combustion synthesis derived TiO2 nanobelts for dye and bacterial degradation
Authors: Eswar Neerugatti KrishnaRao , Ramamurthy Praveen Chandrashekarapura , Madras Giridhar
Published: May 2015

This study demonstrates the synthesis of TiO2 nanobelts using solution combustion derived TiO2 with enhanced photocatalytic activity for dye degradation and bacterial inactivation. Hydrothermal treatment of combustion synthesized TiO2 resulted in unique partially etched TiO2 nanobelts and Ag3PO4 was decorated using the co-precipitation method. The catalyst particles were characterized using X-ray diffraction analysis, BET surface area analysis, diffuse reflectance and electron microscopy. The photocatalytic properties of the composites of Ag3PO4 with pristine combustion synthesized TiO2 and commercial TiO2 under sunlight were compared. Therefore the studies conducted proved that the novel Ag3PO4/unique combustion synthesis derived TiO2 nanobelt composites exhibited extended light absorption, better charge transfer mechanism and higher generation of hydroxyl and hole radicals. These properties resulted in enhanced photodegradation of dyes and bacteria when compared to the commercial TiO2 nanocomposite. These findings have important implications in designing new photocatalysts for water purification.
Melatonin improves bioreductant capacity and silver nanoparticles synthesis using Catharanthus roseus leaves
Authors: Sheshadri S. A. , Sriram S. , Balamurugan P. , Anupriya R. , Princy S. Adline , Brindha P. , Bindu S.
Published: May 2015

Melatonin improved antioxidant potential, therapeutic metabolites and silver nanoparticles (with potent activity against urinary tract pathogens) in Catharanthus roseus leaves.
A study on cell surface hydrophobicity, growth and metabolism of Zymomonas mobilis influenced by PEG as a pretreatment agent
Authors: Nasirpour Niloofar , Mousavi Seyyed Mohammad , Shojaosadati Seyed Abbas
Published: May 2015

This study investigates the effects of polyethylene glycol (PEG) 4000, a non-ionic surfactant, on the cell surface hydrophobicity (CSH) ofZymomonas mobilis, as well as its growth and metabolism.
Investigation of the synthesis and properties of isophorone and ether units based semi-aromatic polyamides
Authors: Zhang Gang , Zhou Yu-xuan , Li Yan , Wang Xiao-Jun , Long Sheng-Ru , Yang Jie
Published: May 2015

The resultant semi-aromatic polyamides showed excellent melt processability and mechanical, thermal and optical properties.
Solution processable polyamines via click chemistry for water purification
Authors: Goud Vanga Devendar , DSouza Roshan , Valiyaveettil Suresh
Published: May 2015

Highly stable amine functionalized polystyrenes were prepared and used for the removal of dissolved pollutants from water.
Synthesis of reduced graphene oxide-montmorillonite nanocomposite and its application in hexavalent chromium removal from aqueous solutions
Authors: Zhang Zilong , Luo Hanjin , Jiang Xiaolu , Jiang Zhongjie , Yang Chen
Published: May 2015

The combination of Mt and rGO protect rGO from aggregation.
A microfluidic chip for high resolution Raman imaging of biological cells
Authors: Liszka Barbara M. , Rho Hoon Suk , Yang Yoonsun , Lenferink Aufried T. M. , Terstappen Leon W. M. M. , Otto Cees
Published: May 2015

A microfluidic chip was designed, prepared and tested for integration with a confocal Raman imaging spectrometer with the specific purpose of enabling studies of individual biological cells.
Tuning the direct growth of Agseedsinto bimetallic Ag@Cu nanorods on surface functionalized electrochemically reduced graphene oxide: enhanced nitrite detection
Authors: Jeena S. E. , Gnanaprakasam P. , Dakshinamurthy Arun , Selvaraju T.
Published: May 2015

The significant challenges in the growth of 1D nanostructure on reduced graphene oxide surface were addressed. It enabled the electrooxidation of the nitrite ion (NO2−) with high sensitivity and good detection limit of 1 nM.
Design and preparation of bio-based dielectric elastomer with polar and plasticized side chains
Authors: Lei Weiwei , Wang Runguo , Yang Dan , Hou Guanyi , Zhou Xinxin , Qiao He , Wang Wencai , Tian Ming , Zhang Liqun
Published: May 2015

Design and preparation of bio-based dielectric elastomer with polar and plasticized side chains showed high actuated strain at low electric field.
Fabrication of InxGa1−xN/GaN QDs with InAlGaN capping layer by coaxial growth on non-(semi-) polar n-GaN NWs using metal organic chemical vapor deposition for blue emission
Authors: Park Ji-Hyeon , Mandal Arjun , Um Dae-Young , Kang San , Lee Da-som , Lee Cheul-Ro
Published: May 2015

Merits of InAlGaN capping layer over self-assembled InxGa1−xN/GaN quantum dots coaxially grown on n-GaN nanowires using MOCVD.
Size-dependent physicochemical properties of mesoporous nanosilica produced from natural quartz sand using three different methods
Authors: Arunmetha Sundaramoorthy , Karthik Arumugam , Srither Saturappan Ravisekaran , Vinoth Murugan , Suriyaprabha Rangaraj , Manivasakan Palanisamy , Rajendran Venkatachalam
Published: May 2015

Mesoporous high-surface-area silica (SiO2) nanoparticles were produced from natural quartz sand (orthoquartzite) using three processing methods namely sol–gel, sonication, and spray pyrolysis.
Using a functional C84 monolayer to improve the mechanical properties and alter substrate deformation
Authors: Lee Wen-Jay , Ho Mon-Shu , Huang Chih-Pong , Chou Che-Fu , Tsai Jyun-Hwei , Su Wan-Sheng
Published: May 2015

Contact stress–distance curves and snapshots of deformation of the C84/Si specimen in the indentation process.
One-pot solvothermal synthesis of S doped BiOCl for solar water oxidation
Authors: Jiang Zaiyong , Liu Yuanyuan , Jing Tao , Huang Baibiao , Wang Zeyan , Zhang Xiaoyang , Qin Xiaoyan , Dai Ying
Published: May 2015

S doping significantly improves the photocatalytic activity of BiOCl, due to the two impurity states induced by S.
Continuous and low error-rate passive synchronization of pre-formed droplets
Authors: Dressler O. J. , Yang T. , Chang S.-I. , Choo J. , Wootton R. C. R. , deMello A. J.
Published: May 2015

A microfluidic droplet-handling architecture for the synchronization of asynchronous, mis-matched, pre-formed droplet streams is demonstrated.
Production of 5-hydroxymethylfurfural from fructose by a thermo-regulated and recyclable Brønsted acidic ionic liquid catalyst
Authors: Ma Yubo , Qing Shaojun , Wang Lei , Islam Nurali , Guan Shuzhe , Gao Zhixian , Mamat Xamxikamar , Li Hongyi , Eli Wumanjiang , Wang Tianfu
Published: May 2015

A thermo-regulated recyclable ionic liquid catalyst bearing acidic functional group for fructose dehydration to produce HMF in 91.2% yield.
Acid/base-regulated reversible electron transfer disproportionation of N–N linked bicarbazole and biacridine derivatives
Authors: Pandit Palash , Yamamoto Koji , Nakamura Toshikazu , Nishimura Katsuyuki , Kurashige Yuki , Yanai Takeshi , Nakamura Go , Masaoka Shigeyuki , Furukawa Ko , Yakiyama Yumi , Kawano Masaki , Higashibayashi Shuhei
Published: May 2015

New acid/base-responsive organic compounds were discovered to undergo electron transfer disproportionation.
Ruddlesden Popper oxides of LnSr3Fe3O10−δ (Ln = La, Pr, Nd, Sm, Eu, and Gd) as active cathodes for low temperature solid oxide fuel cells
Authors: Chaianansutcharit S. , Hosoi K. , Hyodo J. , Ju Y.-W. , Ishihara T.
Published: May 2015

PrSr3Fe3O10−δ, Ruddlesden Popper type oxide, is highly promising as a cathode for low temperature SOFCs.
Planar perovskite solar cells with 15.75% power conversion efficiency by cathode and anode interfacial modification
Authors: Qian Min , Li Meng , Shi Xiao-Bo , Ma Heng , Wang Zhao-Kui , Liao Liang-Sheng
Published: May 2015

Ag NPs and Bphen modified anode and cathode interfaces result in a PCE of 15.75% in perovskite solar cells.
Hierarchical nanowire arrays based on carbon nanotubes and Co3O4 decorated ZnO for enhanced photoelectrochemical water oxidation
Authors: Li Mu , Chang Kun , Wang Tao , Liu Lequan , Zhang Huabin , Li Peng , Ye Jinhua
Published: May 2015

A highly enhanced activity for photoelectrochemical water splitting was achieved by fabricating carbon nanotube (CNT) and Co3O4 decorated hierarchical ZnO nanowire (NW) arrays via a facile stepwise synthesis strategy.
One-pot synthesis of porous monolith-supported gold nanoparticles as an effective recyclable catalyst
Authors: Ye Yonglian , Jin Ming , Wan Decheng
Published: May 2015

Gold nanoparticles can be organized onto a macroscopic surface in a one-pot process, leading to an efficient recyclable catalyst.
Enhanced electropolymerization of poly(xanthurenic acid)–MoS2 film for specific electrocatalytic detection of guanine and adenine
Authors: Yang Tao , Chen Meijing , Nan Fuxin , Chen Lihua , Luo Xiliang , Jiao Kui
Published: May 2015

The electropolymerized PXa–MoS2 hybrid interface based on thin-layer MoS2 exhibited enhanced electrocatalytic activity for aromatic guanine and adenine.
Preparation of different sized nano-silver loaded on functionalized graphene oxide with highly effective antibacterial properties
Authors: Chen Xu , Huang Xiaoquan , Zheng Chuping , Liu Yanan , Xu Taoyuan , Liu Jie
Published: May 2015

The synthesis of GO@PEG@AgNPs composites: step 1, synthesis of single-layer GO, step 2, the amidation reaction between carboxylic groups of GO and amine group of PEG to synthesize GO@PEG, step 3, GO@PEG in the presence the silver nitrate produces a GO@PEG@AgNPs composites.
Simultaneous harvesting of triplet excitons in OLEDs by both guest and host materials with an intramolecular charge-transfer feature via triplet–triplet annihilation
Authors: Zheng Xujun , Peng Qiming , Lin Jie , Wang Yi , Zhou Jie , Jiao Yan , Bai Yuefeng , Huang Yan , Li Feng , Liu Xingyuan , Pu Xuemei , Lu Zhiyun
Published: May 2015

Triplet excitons could be utilized by both guest and host materials with an ICT feature via the TTA process in heavily doped OLEDs.
A large spin-crossover [Fe4L4]8+ tetrahedral cage
Authors: Li Li , Saigo Naoto , Zhang Yingjie , Fanna Daniel J. , Shepherd Nicholas D. , Clegg Jack K. , Zheng Rongkun , Hayami Shinya , Lindoy Leonard F. , Aldrich-Wright Janice R. , Li Chun-Guang , Reynolds Jason K. , Harman David G. , Li Feng
Published: May 2015

A large iron(ii) tetrahedral cage displays temperature induced spin-crossover and liesst effects.
Surface charge transfer induced p-CdS nanoribbon/n-Si heterojunctions as fast-speed self-driven photodetectors
Authors: Xie Chao , Li Fangze , Zeng Longhui , Luo Linbao , Wang Li , Wu Chunyan , Jie Jiansheng
Published: May 2015

Heterojunctions composed of single p-type CdS nanoribbons (NRs) and n-type silicon (Si) were successfully fabricated and can be applied as fast-speed self-driven visible photodetectors.
Ultrasensitive Ag-coated TiO2nanotube arrays for flexible SERS-based optofluidic devices
Authors: Lamberti Andrea , Virga Alessandro , Chiadò Alessandro , Chiodoni Angelica , Bejtka Katarzyna , Rivolo Paola , Giorgis Fabrizio
Published: May 2015

A novel SERS optofluidic sensor based on Ag-decorated TiO2nanotubes has been developed for repeatable detection of organic molecules and biological assays.