bluuebunny/crossref_metadata_2025 huggingface dataset:
To check the antibacterial efficacy against Enterococcus faecalis by various ayurvedic oils used as a solvent in endodontic sealers - An in vitro study
Authors: Kumari Manju , Arora Sharvi , Kochhar Rohit
Published: May 2024

Aim:

The aim of the study is to check the antibacterial efficacy of various ayurvedic oils used as a solvent with zinc oxide for preparing endodontic sealers.

Materials and Methods:

Forty-five extracted premolars were taken and were cut coronally and apically such that 7 mm of tooth specimen was prepared. Teeth were sterilized by autoclaving inoculated with Enterococcus faecalis and incubated for 24 h. The specimens were divided into three groups of 15 each. Group 1 – ZnO powder + Eugenol, Group 2 – ZnO powder + Aremidadi Oil, and Group 3 – ZnO powder + Dashmool oil. Bacterial growth in each specimen was calculated before and after sealer application and noted as the initial and final colony count. The antimicrobial effect of each sealer was measured by calculating the percentage reduction in colony count (%). One-way analysis of variance and post hoc tests will be used for statistical analysis.

Results:

The Zn + Arimedadi oil group showed the maximum antibacterial effect among the sealers tested and the Zn + eugenol sealer showed the least antimicrobial effect In comparison, there was a statistically significant difference between all the groups.

Conclusion:

Ayurvedic oil-based root canal sealers showed better antibacterial efficacy than eugenol-based sealers. Arimedadi oil showed the highest antibacterial activity against E. faecalis and Eugenol showed the least when used as a solvent.
Endodontic management of a maxillary first molar with three roots and six root canals
Authors: Kadulkar Nishad , Kataki Rubi , Deka Adrija , Pharne Vaibhavi
Published: May 2024

Variations in the root canal anatomy of a maxillary first molar are often challenging to diagnose and treat; thus, clinicians must have a thorough knowledge of the same. This case report highlights the successful nonsurgical endodontic management of a maxillary first molar with an unusual morphology of three roots and six root canals. A total of six root canals (mesiobuccal [MB] 1, MB2, MB3, distobuccal [DB] 1, DB2, and palatal) were detected after initiating root canal therapy and access cavity preparation. Conventional root canal treatment was completed, and postoperative cone-beam computed tomography scanning was done to verify the total number of canals and ensure the adequacy of root canal fillings. Managing such cases with rare variations in the root canal systems could be arduous and thus, clinicians should be well-versed in the methods to identify and manage such complexities to facilitate the successful outcomes of endodontic treatment.
Capturing the art and science of dentistry in a lens: Digital dental photography
Authors: Singh Anubha , Prasad Ashwini B. , Raisingani Deepak , Srivastava Harshit , Moryani Vaishali
Published: May 2024

Dental photography is now an excellent tool that plays a crucial role in dentistry as it helps in documenting and analyzing the oral conditions of patients. Photography provides a visual representation of the teeth, gums, and other oral structures, which aids in diagnosis, treatment planning, and monitoring the progress of treatment. Therefore, it is essential for dental professionals to understand the importance of dental photography and incorporate photography it into regular practice. The purpose of this paper is to provide emphasis and elucidate the path of dental photography easier for dental student and practitioner.
Comparative evaluation of the accuracy of two electronic apex locators in detecting simulated incomplete vertical root fractures: An in vitro stereomicroscopic study
Authors: Kararia Nitin , Kararia Vandana , Sharma Deepak , Gupta Shikha , Chaturvedi Saurabh , Chaturvedi Yogita
Published: May 2024

Aim:

The aim of this study was to compare the accuracy of two different electronic apex locators (EALs) in detecting simulated incomplete vertical root fractures (VRFs).

Materials and Methods:

Thirty freshly extracted single-rooted teeth were randomly divided into three groups of 10 teeth each labeled as Groups A, B, and C. Incomplete VRFs were simulated in the coronal, middle, and apical one-third of the roots for Groups A, B, and C, respectively. The teeth were embedded in alginate mold and fracture location was determined with Root ZX and Propex EALs for each sample and each group. To calculate the actual length (AL), each sample was sectioned at the upper level of the vertical fracture, and the length was measured by setting the stopper of the #10 K file under a stereomicroscope at ×30 magnification. The electronic lengths and ALs were compared using computer software, and the results were analyzed using SPSS 28.0 at a 95% confidence level.

Results:

No significant differences were seen in the accuracy of the two EALs when compared with ALs. Root ZX showed significantly longer measurements than ALs in groups B and C.

Conclusion:

The tested EALs showed low accuracy (20%) in detecting simulated incomplete VRFs with a tendency for longer measurements compared to ALs.
Deep margin elevation in class II cavities: A comparative evaluation of microleakage and interface integrity using confocal laser microscopy and scanning electron microscopy
Authors: Reddy K. Hanisha , Priya B. Devi , Malini D.L , Mohan T. Murali , Bollineni Swetha , Gandhodi Hari Chandana
Published: May 2024

Aim:

This study aims to evaluate the microleakage between the gingival seat and base material and to assess the interface integrity between the base material and overlying composite in class II cavities restored using deep margin elevation.

Materials and Methods:

Thirty maxillary molars (n = 30) were taken, and class II cavities were prepared with a gingival seat extending below the cementoenamel junction. These teeth were divided into three groups for subgingival margin elevation using different materials: Group A (n = 10) – flowable composite, Group B (n = 10) – glass ionomer cement (GIC), and Group C (n = 10) – GIC with nanohydroxyapatite (GIC n-HAp). The remaining cavities were restored with bulk-fill composite. After undergoing 1000 thermocycling cycles, half of the samples were examined for microleakage using confocal laser microscopy, and the other half were assessed for interface integrity using scanning electron microscopy. Microleakage was statistically analyzed by one-way ANOVA, and interface integrity was analyzed by Kruskal–Wallis tests.

Results:

The study found that GIC n-HAp exhibited significantly lower microleakage between the base material and gingival seat than flowable composite and GIC. However, regarding interface integrity between the base material and bulk-fill composite, flowable composite, and GIC outperformed GIC n-HAp.

Conclusions:

Incorporating n-HAp into GIC effectively reduced microleakage at the dentin-base material interface. However, the interface integrity between GIC n-HAp and the composite poses a challenge.
Clinicopathological comparison of periapical cyst and periapical granuloma in a cohort of Tamil population
Authors: Immanuel Jeswin , Pandiar Deepak , Krishnan Reshma Poothakulath
Published: May 2024

Aim:

The aim of this study was to present and analyze detailed clinicopathological data of periapical cysts (PCs) and periapical granuloma (PG) in a cohort of 135 cases from the South Indian Population.

Methodology:

The present study included 135 cases of PC and PG out of 2696 biopsies submitted over 3 years. The clinicodemographic data which included age, gender, location, radiographic appearance, and treatment were collected along with the histopathological examination of the biopsied specimen. Data were entered in a Microsoft Excel spreadsheet, 2021, and analyzed using SPSS software ver. 26.

Results:

There were 71 cases of PG and 64 cases of PC. The mean age of occurrence in PG was slightly lower than cases in PC. Irrespective of the group, there was a clear male preponderance, and maxillary permanent central incisors were most commonly affected. However, no significant difference was noted. Radiographically, PC significantly showed more well-defined corticated radiolucent lesions compared to PG where most cases were ill-defined (69.01%). Histologically, all cases showed classic features for diagnosis with additional histological characteristics which may aid in diagnosis.

Conclusion:

PG was more common than PC. There was a predilection for the male gender in both lesions. The actual incidence of these lesions would be actually high, as some cases are lost to private practitioners, and not all the lesions are submitted for histopathological examination.
Comparative evaluation of microhardness of three restorative materials after immersion in chlorhexidine mouthwash: An in vitro study
Authors: Shah Shilpa S. , Patel Nishtha K. , Yagnik Kruti P. , Vyas Aarshati , Doshi Prerak , Keshrani Pooja R.
Published: May 2024

Aim:

To evaluate and compare the microhardness of Filtek Z250XT, Beautifil II, and Neo Spectra ST HV after immersion in chlorhexidine mouthwash.

Materials and Methods:

Thirty disc specimens (10 for each group) made of three different restorative materials, Group 1 – Filtek (3M ESPE), Group 2 – Beautifil II (Shofu), and Group 3 – Neo Spectra ST HV (Dentsply). To simulate 1 year of daily mouthwash use, 10 specimens from each group were immersed in chlorhexidine, kept in an incubator at 37°C for 12 h, and later subjected to microhardness measurement using Vicker’s hardness test. Finally, analysis of variance and post hoc tests were used to analyze the results statistically.

Results:

A significant reduction in microhardness was observed after immersion in chlorhexidine in Groups 1 and 3 compared to Group 2.

Conclusions:

Filtek Z250XT exhibits the highest microhardness compared to the other two materials. However, Beautifil II is more resistant to chlorhexidine mouthwash and does not show a significant reduction compared to the other two restorative materials.
Immunohistochemical study of mixing mineral trioxide aggregate with hyaluronic acid as a pulp-capping agent in dog teeth
Authors: Ahmed Muthanna S. , Saeed Mohammed G. , Hasan Nadia H.
Published: May 2024

Objective:

The purpose of this study was to evaluate the immunohistochemical effect of hyaluronic acid (HA) on the mineralization rate of the reparative dentin when it is used as a mixing medium with mineral trioxide aggregate (MTA).

Materials and Methods:

Direct pulp capping (DPC) was performed on 90 teeth from 10 dogs that had been experimentally exposed. The exposed pulps were divided into three groups according to the mixing medium with MTA: Group I: MTA + distilled water (control group), Group II: MTA + hybrid cooperative complex HA (HCC-HA), Group III: MTA + high molecular weight HA (HMW-HA). After pulp capping, all cavities were restored with final restoration. The dogs were divided randomly into five groups (two dogs each) according to the evaluation periods (7, 14, 21, 30, and 60) days. At the end of the study, the dogs were euthanized, and the sampled teeth were processed for immunohistochemical investigation.

Results:

Both types of HA (HCC-HA, HMW-HA) showed an increase in the expression of alkaline phosphatase (ALP) at a higher rate than using distilled water with MTA.

Conclusions:

Within the limitations of this study, HA proved to be an effective additive to MTA for DPC.
Cydnidae pigmentation
Authors: Selvam Oviya , Singh Yogindher
Published: May 2024

Cydnidae pigmentation is caused by the arthropod Chilocoris assmuthi which is also known as the burrowing bug. The lesion is characterised as asymptomatic brownish red macules which develops on contact with the bug. The sudden onset of such asymptomatic lesions can cause panic to the patient and can also simulate other melanocytic lesions. Hence knowledge about the condition is important to reassure the patient about the harmless nature of the condition and relive their anxiety. We also report a case of nail pigmentation due to Cydnidae in our case series.
Enhancing m6A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury
Authors: Qin Tian , Jin Yuxin , Qin Yiming , Yuan Feifei , Lu Hongbin , Hu Jianzhong , Cao Yong , Li Chengjun
Published: May 2024

JOURNAL/nrgr/04.03/01300535-202506000-00026/figure1/v/2024-08-08T040853Z/r/image-tiff

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine (m6A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m6A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein (METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m6A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m6A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m6A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.
FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression
Authors: Yao Jing , Li Yuan , Liu Xi , Liang Wenping , Li Yu , Wu Liyong , Wang Zhe , Song Weihong
Published: May 2024

JOURNAL/nrgr/04.03/01300535-202507000-00028/figure1/v/2024-09-09T124005Z/r/image-tiff

Alzheimer’s disease is characterized by deposition of amyloid-β, which forms extracellular neuritic plaques, and accumulation of hyperphosphorylated tau, which aggregates to form intraneuronal neurofibrillary tangles, in the brain. The NLRP3 inflammasome may play a role in the transition from amyloid-β deposition to tau phosphorylation and aggregation. Because NLRP3 is primarily found in brain microglia, and tau is predominantly located in neurons, it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory cytokines. Here, we found that neurons also express NLRP3in vitroandin vivo, and that neuronal NLRP3 regulates tau phosphorylation. Using biochemical methods, we mapped the minimalNLRP3promoter and identified FUBP3 as a transcription factor regulatingNLRP3expression in neurons. In primary neurons and the neuroblastoma cell line Neuro2A, FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-β is present. In the brains of aged wild-type mice and a mouse model of Alzheimer’s disease, FUBP3 expression was markedly increased in cortical neurons. Transcriptome analysis suggested that FUBP3 plays a role in neuron-mediated immune responses. We also found that FUBP3 trimmed the 5′ end of DNA fragments that it bound, implying that FUBP3 functions in stress-induced responses. These findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3, and that amyloid-β fundamentally alters the regulatory mechanism ofNLRP3expression in neurons. Given that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer’s disease mice, FUBP3 could be a safe therapeutic target for preventing Alzheimer’s disease progression.
Passive activity enhances residual control ability in patients with complete spinal cord injury
Authors: Xiao Yanqing , Gao Mingming , He Zejia , Zheng Jia , Bai Hongming , Rao Jia-Sheng , Song Guiyun , Song Wei , Li Xiaoguang
Published: May 2024

JOURNAL/nrgr/04.03/01300535-202508000-00024/figure1/v/2024-09-30T120553Z/r/image-tiff

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level. However, because of prolonged inactivity, initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway. A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation, as measured by surface electromyography. In this study, we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury. Eleven patients with chronic complete thoracic spinal cord injury were recruited. Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol. The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation. Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity, the difference was not statistically significant. These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.
Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2
Authors: He Qing , Wang Zhen , Wang Yuchen , Zhu Mengjie , Liang Zhile , Zhang Kanghong , Xu Yuge , Chen Gong
Published: May 2024

JOURNAL/nrgr/04.03/01300535-202506000-00030/figure1/v/2024-08-08T040853Z/r/image-tiff

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore, we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4 (astrocyte endfeet signal), CX43 (gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into pre-existing neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.
Exosomes: the next-generation therapeutic platform for ischemic stroke
Authors: Yin Wenjing , Ma Hongyin , Qu Yang , Ren Jiaxin , Sun Yingying , Guo Zhen-Ni , Yang Yi
Published: May 2024

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional recovery. Therefore, there is an urgent need to develop new methods for the treatment of this condition. Exosomes are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological conditions. They have low immunogenicity, good stability, high delivery efficiency, and the ability to cross the blood–brain barrier. These physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic stroke. The rapid development of nanotechnology has advanced the application of engineered exosomes, which can effectively improve targeting ability, enhance therapeutic efficacy, and minimize the dosages needed. Advances in technology have also driven clinical translational research on exosomes. In this review, we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke, including their anti-inflammation, anti-apoptosis, autophagy-regulation, angiogenesis, neurogenesis, and glial scar formation reduction effects. However, it is worth noting that, despite their significant therapeutic potential, there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified exosomes. Future optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic stroke. Ultimately, our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.
Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets
Authors: Helmold Benjamin R. , Ahrens Angela , Fitzgerald Zachary , Ozdinler P. Hande
Published: May 2024

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.
The Heisenberg covering of the Fermat curve
Authors: Banerjee Debargha , Merel Loïc
Published: May 2024

For N integer

$\ge 1$

, K. Murty and D. Ramakrishnan defined the Nth Heisenberg curve, as the compactified quotient

$X^{\prime }_N$

of the upper half-plane by a certain non-congruence subgroup of the modular group. They ask whether the Manin–Drinfeld principle holds, namely, if the divisors supported on the cusps of those curves are torsion in the Jacobian. We give a model over

$\mathbf {Z}[\mu _N,1/N]$

of the Nth Heisenberg curve as covering of the Nth Fermat curve. We show that the Manin–Drinfeld principle holds for

$N=3$

, but not for

$N=5$

. We show that the description by generator and relations due to Rohrlich of the cuspidal subgroup of the Fermat curve is explained by the Heisenberg covering, together with a higher covering of a similar nature. The curves

$X_N$

and the classical modular curves

$X(n)$

, for n even integer, both dominate

$X(2)$

, which produces a morphism between Jacobians

$J_N\rightarrow J(n)$

. We prove that the latter has image

$0$

or an elliptic curve of j-invariant

$0$

. In passing, we give a description of the homology of

$X^{\prime }_{N}$

.
On Harnack inequality and harmonic Schwarz lemma
Authors: Kargar Rahim
Published: May 2024

In this paper, we study the
$(s, C(s))$
-Harnack inequality in a domain
$G\subset \mathbb {R}^n$
for
$s\in (0,1)$
and
$C(s)\geq 1$
and present a series of inequalities related to
$(s, C(s))$
-Harnack functions and the Harnack metric. We also investigate the behavior of the Harnack metric under K-quasiconformal and K-quasiregular mappings, where
$K\geq 1$
. Finally, we provide a type of harmonic Schwarz lemma and improve the Schwarz–Pick estimate for a real-valued harmonic function.
Association between Dynapenia and Multimorbidity in Community-Dwelling Older Adults: A Systematic Review
Authors: Ohinata Hironori , Yun Shan , Miyajima Naoko , Yuki Michiko
Published: May 2024

Dynapenia and multimorbidity are common health problems affecting older adults. However, few studies have systematically reviewed the association between dynapenia and multimorbidity. Therefore, this systematic review aimed to provide a comprehensive overview of studies on the association between these conditions. We searched four electronic databases for relevant articles published in July 2023. The main inclusion criteria were the following: a description of dynapenia, which indicates loss of muscle strength, and a description of multimorbidity with two or more chronic diseases. Five studies met these inclusion criteria. In all five of these studies, the participants were community-dwelling older adults. All the studies showed an association between dynapenia and multimorbidity. The prevalence of dynapenia and multimorbidity ranged from 16% to 25.9%. The results of our systematic review demonstrated that dynapenia in older adults increases the risk of multimorbidity. We propose that interventions and reversible changes in dynapenia can prevent multimorbidity. (PROSPERO Registration No. CRD42023443282)
Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now
Authors: Pappachan Joseph M , Fernandez Cornelius James , Ashraf Ambika P
Published: May 2024

Childhood-onset obesity has emerged as a major public healthcare challenge across the globe, fueled by an obesogenic environment and influenced by both genetic and epigenetic predispositions. This has led to an exponential rise in the incidence of type 2 diabetes mellitus in children and adolescents. The looming wave of diabetes-related complications in early adulthood is anticipated to strain the healthcare budgets in most countries. Unless there is a collective global effort to curb the devastation caused by the situation, the impact is poised to be pro-found. A multifaceted research effort, governmental legislation, and effective social action are crucial in attaining this goal. This article delves into the current epidemiological landscape, explores evidence concerning potential risks and consequences, delves into the pathobiology of childhood obesity, and discusses the latest evidence-based management strategies for diabesity.
Associations of serum D-dimer and glycosylated hemoglobin levels with third-trimester fetal growth restriction in gestational diabetes mellitus
Authors: Zhang Ying , Li Teng , Yue Chao-Yan , Liu Yun
Published: May 2024

BACKGROUND

Gestational diabetes mellitus (GDM) is a special type of diabetes that commonly occurs in women during pregnancy and involves impaired glucose tolerance and abnormal glucose metabolism; GDM is diagnosed for the first time during pregnancy and can affect fetal growth and development.

AIM

To investigate the associations of serum D-dimer (D-D) and glycosylated hemoglobin (HbA1c) levels with third-trimester fetal growth restriction (FGR) in GDM patients.

METHODS

The clinical data of 164 pregnant women who were diagnosed with GDM and delivered at the Obstetrics and Gynecology Hospital of Fudan University from January 2021 to January 2023 were analyzed retrospectively. Among these women, 63 whose fetuses had FGR were included in the FGR group, and 101 women whose fetuses had normal body weights were included in the normal body weight group (normal group). Fasting venous blood samples were collected from the elbow at 28-30 wk gestation and 1-3 d before delivery to measure serum D-D and HbA1c levels for comparative analysis. The diagnostic value of serum D-D and HbA1c levels for FGR was evaluated by receiver operating characteristic analysis, and the influencing factors of third-trimester FGR in GDM patients were analyzed by logistic regression.

RESULTS

Serum fasting blood glucose, fasting insulin, D-D and HbA1c levels were significantly greater in the FGR group than in the normal group, while the homeostasis model assessment of insulin resistance values were lower (P < 0.05). Regarding the diagnosis of FGR based on serum D-D and HbA1c levels, the areas under the curves (AUCs) were 0.826 and 0.848, the cutoff values were 3.04 mg/L and 5.80%, the sensitivities were 81.0% and 79.4%, and the specificities were 88.1% and 87.1%, respectively. The AUC of serum D-D plus HbA1c levels for diagnosing FGR was 0.928, and the sensitivity and specificity were 84.1% and 91.1%, respectively. High D-D and HbA1c levels were risk factors for third-trimester FGR in GDM patients (P < 0.05).

CONCLUSION

D-D and HbA1c levels can indicate the occurrence of FGR in GDM patients in the third trimester of pregnancy to some extent, and their combination can be used as an important index for the early prediction of FGR.
A ação universal do Espírito Santo
Authors: Merone Fabrizio
Published: May 2024

A ação universal do Espírito Santo
Sacramento da Penitência e Espírito Santo
Authors: Francisco Manoel João
Published: May 2024

Sacramento da Penitência e Espírito Santo
A paz – que paz?
Authors: Pereira Ney Brasil
Published: May 2024

A paz – que paz?
A justiça e a paz na ótica da CJP
Authors: Medeiros Paulo Leonardo Vieira
Published: May 2024

A justiça e a paz na ótica da CJP
A espiritualidade presbiteral diocesana
Authors: Buss Nilo
Published: May 2024

A espiritualidade presbiteral diocesana
Soluções para a crise do Judiciário
Authors: Medeiros Vieira Franciso Xavier
Published: May 2024

Soluções para a crise do Judiciário
A PM de Santa Catarina e o serviço de assistência religiosa
Authors: Groh Valdemar
Published: May 2024

A PM de Santa Catarina e o serviço de assistência religiosa
A Igreja e a pena de prisão
Authors: Cervi Henrique Ernesto
Published: May 2024

A Igreja e a pena de prisão
A inteligência da fé num contexto de pós-modernidade
Authors: Brighenti Agenor
Published: May 2024

A inteligência da fé num contexto de pós-modernidade
Batismo e missão
Authors: Goedert Valter Maurício
Published: May 2024

Batismo e missão
A Doutrina Social da Igreja em João Paulo II
Authors: Carrascosa Andrés
Published: May 2024

A Doutrina Social da Igreja em João Paulo II
A Igreja na região da Grande Palmas
Authors: Tedesco Adayr
Published: May 2024

A Igreja na região da Grande Palmas
Educação Educante e Fraterna
Authors: Sachet Celestino
Published: May 2024

Educação Educante e Fraterna
Mestres: não basta saber (o mestre Jesus em Lucas)
Authors: Loraschi Celso
Published: May 2024

Mestres: não basta saber (o mestre Jesus em Lucas)
Pastoral universitária: educação para o Reino
Authors: Zamparetti Cláudio
Published: May 2024

Pastoral universitária: educação para o Reino
A nova lei do Ensino Religioso
Authors: Della Giustina Elias
Published: May 2024

A nova lei do Ensino Religioso
A educação religiosa escolar ecumênica em Santa Catarina
Authors: Thomé Ione , Furlan Emio
Published: May 2024

A educação religiosa escolar ecumênica em Santa Catarina
Charbonneau, o perfil de um Educador
Authors: Medeiros Franciso Vieira
Published: May 2024

Charbonneau,  o perfil de um Educador
A simbólica dos Impérios do Divino
Authors: Pereira Nereu do Vale
Published: May 2024

A simbólica dos Impérios do Divino
Recensões
Authors: Souza Caldas Carlos Antônio
Published: May 2024

Recensões
O clamor do desemprego, no mundo e em SC
Authors: Corte Glauco José
Published: May 2024

O clamor do desemprego, no mundo e em SC
Curso universitário é garantia de emprego?
Authors: Rampinelli Waldir José
Published: May 2024

Curso universitário é garantia de emprego?
Trabalho, salário e justiça ,em Mateus 20,1-16,58
Authors: Pereira Ney Brasil
Published: May 2024

Trabalho, salário e justiça ,em Mateus 20,1-16,58
Deus Pai e os excluídos
Authors: Feller Vitor Galdino
Published: May 2024

Deus Pai e os excluídos
A formação da sociedade disciplinar catarinense
Authors: Souza Rogério Luiz de
Published: May 2024

A formação da sociedade disciplinar catarinense
O bispo e seu ministério
Authors: Francisco Manoel João
Published: May 2024

O bispo e seu ministério
Deus é bom
Authors: Scheid Eusébio Oscar
Published: May 2024

Deus é bom
A comunicação do Pai
Authors: Nandi Domingos Vonei
Published: May 2024

A comunicação do Pai
Lutero e o sacramento da Penitência
Authors: Francisco Manoel João
Published: May 2024

Lutero e o sacramento da Penitência
Reconciliação e sociedade – Por uma ética dos Direitos econômicos
Authors: Vicente Vilmar Adelino
Published: May 2024

Reconciliação e sociedade – Por uma ética dos Direitos econômicos
Os caminhos da CF-2000 Ecumênica
Authors: Wloch Francisco de Assis
Published: May 2024

Os caminhos da CF-2000 Ecumênica
O Deus de nossos sonhos
Authors: Debiasi Evaristo
Published: May 2024

O Deus de nossos sonhos
A Eucaristia segundo João (Jo 6,51-58)
Authors: Pereira Ney Brasil
Published: May 2024

A Eucaristia segundo João (Jo 6,51-58)
Memória e reconciliação no Grande Jubileu
Authors: Besen José Artulino
Published: May 2024

Memória e reconciliação no Grande Jubileu
Diretrizes do tratamento da dependência nas Comunidades Terapêuticas
Authors: Brincas Jairo
Published: May 2024

Diretrizes do tratamento da dependência nas Comunidades Terapêuticas
O antissemitismo cristão e a Shoah
Authors: Besen José Artulino
Published: May 2024

O antissemitismo cristão e a Shoah
A invenção de um novo milênio: questões de gênero na sociedade e na Igreja
Authors: Antunes Marta Magda
Published: May 2024

A invenção de um novo milênio: questões de gênero na sociedade e na Igreja
Um bispo brasileiro para a África - depoimento
Authors: Zilli Pedro Carlos
Published: May 2024

Um bispo brasileiro para a África  - depoimento
A questão da terra e o direito dos povos indígenas
Authors: Santos Sílvio Coelho dos
Published: May 2024

A questão da terra e o direito dos povos indígenas
Palavra e terra – Reflexões sobre a expressão “em busca de Yvy Porã/Tekoa porã” no litoral do estado de Santa Catarina
Authors: Darella Maria
Published: May 2024

Palavra e terra – Reflexões sobre a expressão “em busca de Yvy Porã/Tekoa porã” no litoral do estado de Santa Catarina
A prioridade é a demarcação das terras
Authors: Brighenti Clóvis
Published: May 2024

A prioridade é a demarcação das terras
Reencontrar as vias da Esperança na memória retrabalhada – o legado de Paul Ricoeur
Authors: Bartel Márcio
Published: May 2024

Reencontrar as vias da Esperança na memória retrabalhada – o legado de Paul Ricoeur
Bispos na primavera de renovação que marcou a gênese da CNBB
Authors: Barros Raimundo Caramuru
Published: May 2024

Bispos na primavera de renovação que marcou a gênese da CNBB
Testemunhos sobre o significado do Concílio Vaticano II e da CNBB para o ministério episcopal
Authors: Diversos Autores
Published: May 2024

Testemunhos sobre o significado do Concílio Vaticano II e da CNBB para o ministério episcopal
Liturgia: celebração do mistério de Cristo
Authors: Goedert Valter
Published: May 2024

Liturgia: celebração do mistério de Cristo
A dignidade do leigo
Authors: Albuquerque Moacir José
Published: May 2024

A dignidade do leigo
Mediação cultural e processo de desistoricização do discurso teológico
Authors: Rocha Alessandro
Published: May 2024

Mediação cultural e processo de desistoricização do discurso teológico
O trabalho dos mineiros no sul de Santa Catarina
Authors: Damázio Pedro José
Published: May 2024

O trabalho dos mineiros no sul de Santa Catarina
O trabalho de Deus e o nosso trabalho
Authors: Pereira Ney Brasil
Published: May 2024

O trabalho de Deus e o nosso trabalho
A dimensão do trabalho no processo de formação presbiteral
Authors: Feller Vitor Galdino
Published: May 2024

A dimensão do trabalho no processo de formação presbiteral
A espiritualidade do trabalho segundo a “Laborem Exercens”
Authors: Gritti Alberto
Published: May 2024

A espiritualidade do trabalho segundo a “Laborem Exercens”
João Paulo II no Brasil: tentativa de síntese
Authors: Bratti Paulo
Published: May 2024

João Paulo II no Brasil: tentativa de síntese
Projeto Igrejas Irmãs
Authors: Giustina Elias Della
Published: May 2024

Projeto Igrejas Irmãs
A formação sacerdotal em SC – Seminários Menores
Authors: Besen José Artulino
Published: May 2024

A formação sacerdotal em SC – Seminários Menores
Família, filiocracia e juventude
Authors: Debiasi Evaristo
Published: May 2024

Família, filiocracia e juventude
Irmã Violeta, a violeta que Deus colheu
Authors: Diretor Editor
Published: May 2024

Irmã Violeta, a violeta que Deus colheu
O fenômeno da evangelização
Authors: Silva Márcio Bolda da
Published: May 2024

O fenômeno da evangelização
Arte e evangelização na América Latina
Authors: Milanez Terezinha
Published: May 2024

Arte e evangelização na América Latina
Sirácida ou Eclesiástico
Authors: Besen José Artulino
Published: May 2024

Sirácida ou Eclesiástico
Elementos para uma crítica histórica do Documento de Santo Domingo
Authors: Brighenti Agenor
Published: May 2024

Elementos para uma crítica histórica do Documento de Santo Domingo
Grupos de família: uma proposta de pastoral familiar
Authors: Wolff Elias
Published: May 2024

Grupos de família: uma proposta de pastoral familiar
“Catequese: lugar da educação política”
Authors: Kestering Juventino
Published: May 2024

“Catequese: lugar da educação política”
“A política na atual legislação da Igreja”
Authors: Cervi Henrique Ernesto
Published: May 2024

“A política na atual legislação da Igreja”
Os excluídos e as CEBs
Authors: Haas Verônica Velho
Published: May 2024

Os excluídos e as CEBs
Pastoral da Juventude catarinense e Cf-95
Authors: Lima José Dias
Published: May 2024

Pastoral da Juventude catarinense e Cf-95
Para uma leitura sócio-teológica da marginalidade social na AL
Authors: Wolff Elias
Published: May 2024

Para uma leitura sócio-teológica da marginalidade social na AL
Impressões sobre a IX Assembleia Geral Ordinária do Sínodo dos Bispos
Authors: Scheid Eusébio
Published: May 2024

Impressões sobre a IX Assembleia Geral Ordinária do Sínodo dos Bispos
The readiness and acceptance of patients with tuberculosis to use telecare
Authors: Octavia Devi Ristian , Hermansyah Andi , Nita Yunita
Published: May 2024

Background: Tuberculosis (TB) has been a global health burden and a leading infectious killer. The evolving healthcare technology allows telecare services to improve treatment support for TB patients. However, patient readiness and acceptance to use the service still need to be discovered.
Objective: To evaluate the readiness and acceptance of TB patients in using telecare services.
Methods: A cross-sectional survey involving patients at a respiratory hospital in Surabaya, Indonesia, was conducted using an accidental sampling technique from April to June 2023. A validated questionnaire was developed from the technology readiness index (TRI) and technology acceptance model (TAM) framework. Data were analysed using partial least squares-structural equation modelling (PLS-SEM).
Results: A total of 188 respondents participated. Respondents had low to medium-range attitudes towards a readiness to use the telecare service. Nevertheless, the majority of the respondents accepted the idea of telecare service. Optimism and innovativeness were two significant factors influencing patient readiness to use telecare services. Respondents had a positive perception of the perceived ease of use and perceived usefulness of the service.
Conclusion: Not all patients were ready to use telecare despite their high acceptance towards the service. However, the positive perception towards the benefits of the service can be the leveraging factor for gradually adopting the service.
Knowledge and uses of iron supplements to treat anaemia among adolescent girls in Surabaya
Authors: Jihanwasila Nafiladiniaulia , Achmad Gusti Noorrizka Veronika , Andarsari Mareta Rindang , Yuda Ana
Published: May 2024

Background: During adolescence, a phase of growth and development requires a lot of macros and micronutrient intake. The physical changes will certainly affect nutritional status, leading to nutritional problems, such as anaemia.    
Objective: To determine the level of knowledge of adolescent girls about iron supplements and how they use them to overcome anaemia.
Method: A descriptive study with a cross-sectional design was used in this research, and an accidental sampling technique was used.
Result: Most of the respondents need better knowledge, despite most of them having taken iron supplements from school, which is a part of the programs from the government. Many respondents have received information about iron supplements and anaemia, but numerous still do not comply with taking iron supplements.
Conclusion: Education needs to be carried out to increase the compliance of adolescent girls in using iron supplements to improve the quality of the next generation.
Toxicidade Associada ao Peeling de Fenol: Uma Revisão Integrativa da Literatura
Authors: Horst Dornelles Mariana , Tibolla Viero Fernanda , Da Silva Brenda
Published: May 2024

Atualmente a vaidade e a preocupação em manter a jovialidade, vem aumentando a busca por procedimentos estéticos capazes de reduzir os efeitos do envelhecimento. O Peeling de Fenol, por exemplo, que promove intensa renovação celular tem sido frequentemente utilizado para a melhoria da qualidade da pele. No entanto, há poucos estudos que avaliem os efeitos tóxicos associados ao fenol em procedimentos estéticos. Diante disso, este trabalho objetiva avaliar os efeitos tóxicos associados ao peeling de fenol, por meio de uma revisão sistemática do tipo integrativa. A busca considerou artigos publicados no período de 2013 a 2023 nas bases eletrônicas Pubmed, Scielo e Scopus. Foram selecionados 7 artigos sendo que apenas um tinha por escopo avaliar a toxicidade cutânea, renal e cardíaca em concentrações diferentes de fenol, e os demais avaliam apenas a eficácia do procedimento em diferentes combinações. O fenol é um composto tóxico que penetra facilmente na epiderme, sendo rapidamente absorvido pela corrente sanguínea. Este estudo descreve pela primeira vez as características que o fenol em diferentes concentrações promove um aumento da frequência cardíaca, gera arritmias e aumenta a pressão arterial, além de que pode promover lesões cutâneas cáusticas e elevação das transaminases hepáticas.
MENINGKATKAN KEMAMPUAN MOTORIK HALUS MELALUI KEGIATAN KOLASE BAHAN BEKAS PADA ANAK KELOMPOK B DI PAUD AZ-ZAHRA INSTITUT AHMAD DAHLAN PROBOLINGGO
Authors: Latifah  , Prasetiya Benny
Published: May 2024

The development of children's fine motor skills at PAUD AZ-ZAHRA Lekok Pasuruan is still weak, this is because the choice of methods and tools used do not attract the child's attention, or perhaps the child is too bored with materials that only use ingredients. crayon. every day So our researchers want to use new methods and materials to present a collage of used materials. This type of research was classroom action research which aims to improve the fine motor skills of group B or 20 children. This research material was prepared through observation and documentation. The results of this research were carried out in two cycles, namely Cycle I and Cycle II. At the same time there was a revival in cycle II. The conclusion of the research is that the development of children's fine motor skills through neck activities made from used materials has increased rapidly.
Keywords: Collage, Early childhood education, Fine motor skills
The Effect of Group Psychotherapy on the Mental Health of Servicemen with Post-Traumatic Stress Disorder
Authors: Motoziuk Liudmyla , Chorna Nataliia , Lukashuk Maryna , Vlasov Volodymyr , Sobkova Svitlana
Published: May 2024

The aim of the article is to determine the conditions for the effective use of group psychotherapy in working with servicemen with post-traumatic stress disorder (PTSD). The research employed the methods of testing and formative experiment. The sample consisted of the servicemen with PTSD symptoms. The group psychotherapy programme demonstrated uneven effectiveness. The effectiveness of individual and group work in reducing the symptoms of re-experiencing the event is moderate. Manifestations of avoiding traumatic situations did not change significantly in the process of group influence, while a moderate positive influence was recorded in the case of applying an individual approach. Group psychotherapy is the most effective in working with symptoms of emotional arousal of servicemen, which results from trauma. The significance of the implementation of the obtained results lies in the development of effective programmes and protocols of psychotherapy aimed at overcoming post- traumatic stress disorder of veterans and combatants. Further research may focus on expanding the research sample and the implementation of an experimental combination of individual and group psychotherapy in the work with servicemen with PTSD.
Aproximación a las categorías: Espiritualidad, Salud y Bienestar. Una mirada hacia las técnicas que las propician
Authors: Vargas-Acosta Eglee , Navas Perozo Rita , Nuvaez de De Armas Mairely
Published: May 2024

Factores psicológicos, sociales, conductuales y biológicos han sido investigados como posibles características protectoras o perjudiciales para la salud y el bienestar, pero sus influencias o relaciones con la espiritualidad no se han examinado en gran medida en la investigación de la salud; de allí que el objetivo de esta investigación fue establecer una aproximación al estudio de las categorías de Espiritualidad, Salud y Bienestar, su posible interrelación, así como examinar las técnicas que la propician con base en una revisión de la literatura científica de diversos teóricos. En conclusión, los resultados mostraron con respecto a la conceptualización sobre Espiritualidad que aun cuando no existe consenso, los autores coinciden que se asume como una categoría multidimensional y esencial en el ser humano como experiencia individual, un modo de vida que comprende valores y creencias. También se encontró una relación entre la espiritualidad y el mejoramiento de la salud, junto con una estrecha vinculación entre la espiritualidad y bienestar, existiendo una diversidad de técnicas, que contribuyen al bienestar y éste se puede lograr desde la promoción de la espiritualidad.