bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring sustainability consciousness as a psychological construct with undergraduate students in the Republic of Korea
Authors: Yoo Sung-Sang , Kim Gahyung , La Soo Jung , Sung YooJeo
Published: February 2024

Purpose

This paper explores how sustainability consciousness varies among undergraduate students at a higher education institution in the Republic of Korea. Based on the analyses of survey data, this paper aims to understand the present state and future prospect of education for sustainable development, specifically within higher education in the Republic of Korea.

Design/methodology/approach

This study involves analyzing 254 complete responses from undergraduate students at Seoul National University using confirmatory factor analysis. Subsequently, it explores how five variables (gender, grade year, type of college, prior exposure to sustainable development and prior exposure to education for sustainable development) influence the level of sustainability consciousness among these undergraduates.

Findings

The goodness-of-fit indices of the adapted sustainability consciousness questionnaire indicate a good fit. The analysis reveals a notable gender-based disparity in sustainability consciousness, with female students exhibiting higher levels than their male counterparts. Additionally, academic progression also affects sustainability consciousness; students in their first and second years show greater awareness compared to those in their third year. Furthermore, the academic discipline of respondents plays a role, as evidenced by students from the College of Education displaying higher sustainability consciousness than those from other colleges.

Originality/value

This research distinguishes itself from prior studies in two key dimensions. First, it offers an analysis of the sustainability consciousness among South Korean undergraduate students, with a particular focus on those who have experienced the COVID-19 pandemic. Second, this study endeavors to establish the validity of sustainability consciousness as a psychological construct, expanding the understanding of its implications and relevance in the context of higher education.
How the interaction of innovation and ERP systems on business intelligence affects the performance of Mexican manufacturing companies
Authors: Lara-Pérez Jorge Alfonso , Canibe-Cruz Francisco , Duréndez Antonio
Published: February 2024

Purpose

The present study shows that the implementation and development of enterprise resource planning (ERP) systems as a technological innovation provide a competitive advantage that helps to improve the functionality of business intelligence (BI) systems in the digital transformation of manufacturing companies, in addition to improving overall firm performance.

Design/methodology/approach

The research uses the structural equation approach based on PLS-SEM technique with a sample of 120 firms in the manufacturing industry in Coahuila, Mexico.

Findings

The paper provides empirical insights into how the interaction of ERP systems and innovation significantly affects the functionality of BI Systems and has a substantial effect on overall firm performance.

Originality/value

Empirical evidence of how advanced digital management systems (ERP and BI) impact digitalization processes in organizations by improving performance is still scarce.
Dealing with risk in stakeholder dialog: identification of risk indicators in a public service media organization's conversation and discourse with citizens
Authors: Schwägerl Christian , Stücheli-Herlach Peter , Dreesen Philipp , Krasselt Julia
Published: February 2024

Purpose

This study operationalizes risks in stakeholder dialog (SD). It conceptualizes SD as co-produced organizational discourse and examines the capacities of organizers' and stakeholders' practices to create a shared understanding of an organization’s risks to their mutual benefit. The meetings and online forum of a German public service media (PSM) organization were used as a case study.

Design/methodology/approach

The authors applied corpus-driven linguistic discourse analysis (topic modeling) to analyze citizens' (n = 2,452) forum posts (n = 14,744). Conversation analysis was used to examine video-recorded online meetings.

Findings

Organizers suspended actors' reciprocity in meetings. In the forums, topics emerged autonomously. Citizens' articulation of their identities was more diverse than the categories the organizer provided, and organizers did not respond to the autonomous emergence of contextualizations of citizens' perceptions of PSM performance in relation to their identities. The results suggest that risks arise from interactionally achieved occasions that prevent reasoned agreement and from actors' practices, which constituted autonomous discursive formations of topics and identities in the forums.

Originality/value

This study disentangles actors' practices, mutuality orientation and risk enactment during SD. It advances the methodological knowledge of strategic communication research on SD, utilizing social constructivist research methods to examine the contingencies of organization-stakeholder interaction in SD.
From hospital-centered care to home-centered care of older people: propositions for research and development
Authors: Poksinska Bonnie , Wiger Malin
Published: February 2024

Purpose

Providing high-quality and cost-efficient care of older people is an important development priority for many health and social care systems in the world. This paper suggests a shift from acute, episodic and reactive hospital-centered care toward longitudinal, person-centered and proactive home-centered care. The purpose of this paper is to contribute to the knowledge of a comprehensive development strategy for designing and providing home-centered care of older people.

Design/methodology/approach

The study design is based on qualitative research with an inductive approach. The authors study development initiatives at the national, regional and local levels of the Swedish health and social care system. The data collection methods included interviews (n = 54), meeting observations (n = 25) and document studies (n = 59).

Findings

The authors describe findings related to policy actions and system changes, attempts to achieve collaboration, integration and coordination, new forms of care offerings, characteristics of work settings at home and differences in patients' roles and participation at home and in the hospital.

Practical implications

The authors suggest home-centered care as a solution for providing person-centered and integrated care of older people and give examples of how this can be achieved.

Originality/value

The authors outline five propositions for research and development related to national policies, service modularity as a solution for customized and coordinated care, developing human resources and infrastructure for home settings, expanding services that enable older people living at home and patient co-creation.
Is Takāful industry fulfilling Maqāṣid al-Shar ī’ ah? The proposition of a new evaluation model using analytic hierarchy process
Authors: Islam Rafikul , Md. Tarique Kazi , Razali Siti Salwani
Published: February 2024

Purpose

The Takāful (Islamic insurance) industry operates on the principles of Maqāṣid al-Sharī’ah, and of late, the industry has witnessed significant market growth. The purpose of this study is to develop a performance measurement model based on Maqāṣid al-Sharī’ah to evaluate the performance of Takāful firms.

Design/methodology/approach

A mixed-method research approach was adopted to conduct the present study. Priorities were assigned to various dimensions of the Maqāṣid model using analytic hierarchy process and by taking inputs from 18 Takāful experts. On the contrary, six experts were involved in identifying the elements and measures for the operationalization of the Maqāṣid dimensions.

Findings

Maṣlaḥa (0.359) was found to possess the highest priority, followed by Justice (0.345) and Educating Individuals (0.295). Furthermore, under Necessity, protection of religion (0.398) and protection of life (0.388) are assigned almost similar priorities. These two are followed by the protection of progeny (0.107), protection of wealth (0.058) and protection of intellect (0.047). The final outcome of this study is a hierarchical model for the evaluation of performance of Takāful firms.

Practical implications

The application of the performance evaluation model will provide information to the management of Takāful firms on where they stand in terms of fulfilling Maqāṣid al-Sharī’ah principles. If any firms are found to have a deficiency in a certain part of Maqāṣid components, then proper and adequate measures can be taken to ameliorate the situation.

Originality/value

It is necessary to have a performance evaluation model based upon Maqāṣid al-Sharī’ah to evaluate the performance of Takāful firms as these firms operate on the principles of Maqāṣid al-Sharī’ah. Because there does not exist any such model, this study fills up this gap. Details of the measures that can be used to evaluate the performance of Takāful firms are also provided.
Nature of student housing in Ghana: drivers of physical health condition effects on students living with disability (SWD) in Purpose-Built university housing
Authors: Appau Miller Williams , Attakora-Amaniampong Elvis , Anugwo Iruka Chijindu
Published: February 2024

Purpose

Providing student housing designed to support students living with a disability is a global challenge. This study assesses buildings' physical health condition systems and drivers of physical health condition effects on students living with disability (SWD) in purpose-built university housing in Ghana.

Design/methodology/approach

The study used quantitative design and methods based on the theory of supportive design premises. Using the partial least square structural equation model, a survey of 301 students living with a physical disability, mild visual disability and mild hearing disability was collected in 225 student housings.

Findings

The study found that insect control and cleaning services are a priority in off-campus building design and management and directly positively affected the sense of control and physical health of SWD. The nature of lightning systems, noise and thermal comfort directly negatively affected SWD disability learning and discomfort.

Practical implications

Reviewing and enforcing student housing design drawings at the preliminary development stage by university management is critical. More broadly, physical health systems that control cleaning, noise and thermal comfort are essential for SWD health in student housing.

Originality/value

Studies on all-inclusive building designs have consistently focused on lecture theaters and libraries with limited attention on the physical health condition systems in student housing that support the quality healthcare of university campuses. Research on physical health condition systems in student housing is significant for all-inclusiveness and student housing management.
Critical realism, ethnography and translations: an investigation into a Japanese school
Authors: Derrah Richard H.
Published: February 2024

Purpose

In this article, I explore how critical realism influenced the methods and methodology as well as the translations of interviews from Japanese into English and the interpretations of teachers’ understanding of the school at the center of this research.

Design/methodology/approach

This article investigates the interaction of critical realism within an English-language-based study of a Japanese high school using ethnographic methods and methodology and its influence on translations within the study. Critical realism combines a postpositivist ontological view with an epistemological constructionism. There is a reality to the school, which cannot be completely measured. This reality, the physical dimensions and composition (breadth, height, volume and number of classrooms) of the school, does not change based upon time or viewing location of an observer.

Findings

Critical realism provided strategies for and a focus on the translation of participant interviews from Japanese into English within this ethnographic study of a high school in Japan. These helped to provide a better understanding of the teachers' perception of the reality of the school.

Originality/value

This is original research.
Being on the inside: a research methodology for data collection within the inner circle of the domain of video game translation/localization in Thailand
Authors: Techawongstien Koraya
Published: February 2024

Purpose

The Thai video game domain has witnessed substantial growth in recent years. However, many games enjoyed by Thai players are in foreign languages, with only a handful of titles translated/localized into the Thai locale. Some Thai video game enthusiasts have taken on the role of unofficial translators/localizers, contributing to a localization domain that accommodates both official and unofficial translation/localization efforts. This general review paper aims to outline the author's experiences in collecting data within the domain of video game translation/localization in Thailand.

Design/methodology/approach

Using a descriptive approach, this general review paper employs the netnography method. It sheds light on the complexities of video game translation/localization in Thailand and incorporates semi-structured interviews with a snowball sampling technique for the selection of participants and in-game data collection methods.

Findings

The netnography method has proved instrumental in navigating the intricacies of this evolving landscape. Adopting the netnography method for data collection in this research contributes to establishing more robust connections with the research sites. “Inside” professionals and individuals play a significant role in data gathering by recommending additional sources of information for the research.

Originality/value

While netnography is conventionally applied in the market and consumer research, this paper demonstrates its efficacy in unraveling the dynamics of video game translation/localization in Thailand.
Carbon intensity constraint policy and firm green innovation in China: a quasi-DID analysis
Authors: Xu Jinhua , Ye Feisan , Li Xiaoxia
Published: February 2024

Purpose

This paper aims to empirically investigate the impact of the carbon intensity constraint policy (CICP) on green innovation.

Design/methodology/approach

This study takes the implementation of the CICP as a quasi-natural experiment and uses a quasi–difference-in-difference method to investigate the impact of the CICP on firm green innovation from a microeconomic perspective.

Findings

The CICP significantly limits the quality of firms’ green innovation. Among the range of green patents, the CICP distorts only patents related to CO2 emissions. The inhibitory effect is more pronounced in non-state-owned enterprises and heavily polluting firms. R&D investment and green investor are identified as the main mechanism.

Practical implications

These findings provide evidence for the influence of the CICP on firm green innovation, which can guide policymakers in China and other emerging economies that prioritize carbon intensity constraint targets and the improvement of relevant auxiliary measures.

Social implications

Governments and firms should have a comprehensive understanding of environmental policies and corporate behavior and need to mitigate the negative impact through a combination of measures.

Originality/value

This study contributes to the literature by providing additional empirical evidence regarding the two opposing sides of the ongoing debate on the positive or negative effects of CICP. It also provides new evidence on the policy effect of the CICP on firm green innovation, together with its mechanisms and heterogeneous influences.
The idea of adaptation in transaction cost economics: an application to stakeholder theory
Authors: Valentinov Vladislav , Iliopoulos Constantine
Published: February 2024

Purpose

Transaction cost economics sees a broad spectrum of governance structures spanned by two types of economic adaptation: autonomous and cooperative. Stakeholder theorists have drawn much inspiration from transaction cost economics but have not paid explicit attention to the centrality of the idea of adaptation in this literature. This study aims to address this gap.

Design/methodology/approach

The authors develop a novel conceptual framework applying the distinction between the two types of economic adaptation to stakeholder theory.

Findings

The authors argue that the idea of cooperative adaptation is particularly useful for describing the firm’s collaboration with primary stakeholders in the joint value creation process. In contrast, autonomous adaptation is more relevant for firms interacting with secondary stakeholders who are not directly engaged in joint value creation and may not have formal contractual relationships with the firm. Accordingly, cooperative adaptation can be seen as vital for resolving team production problems affecting joint value creation, whereas autonomous adaptation addresses how the firm maintains legitimacy within the larger stakeholder environment.

Originality/value

Similar to its significance for transaction cost economics, the distinction between the two types of adaptation equips stakeholder theory with a new systematic understanding of a potentially broad spectrum of firm–stakeholder collaboration forms.
Stock buybacks in the spotlight
Authors: Campbell Katherine , Ellingson Dee Ann , Weiss Jane M.
Published: February 2024

Theoretical Basis

The theoretical basis for the case is information asymmetry and signaling theory, with buybacks providing a mechanism for reducing information asymmetry between management and investors. The controversy surrounding buybacks has led to political and regulatory scrutiny, which, consistent with evidence from academic research, may affect corporate behavior.

Research methodology

The compact case is based on secondary, public information about stock buybacks. All sources used are cited in-text, with full citations included in the references section at the end of the teaching note.

Case Overview/Synopsis

Stock buybacks, a means of providing returns to shareholders, have recently received increased scrutiny by politicians, media and shareholder activists. Proponents have argued that buybacks result in efficient allocation of capital by returning funds to shareholders, whereas opponents have criticized buybacks for enriching executives, providing tax advantages to shareholders and contributing to income inequality. Corporations did not curtail their use of buybacks after the Inflation Reduction Act of 2022 imposed an excise tax. The case frames the buyback debate in current events and focuses on the buyback activity of Apple. The case provides students the opportunity to analyze alternative ways that companies can provide returns to shareholders, evaluate impacts of buybacks on corporate stakeholders and appraise the reasons for, and implications of, current controversy regarding buybacks.

Complexity/Academic Level

This compact case is appropriate for upper-level undergraduate or graduate courses in financial accounting, tax and finance. This case provides an opportunity to analyze and evaluate stock buyback decisions in the context of the current controversy related to buybacks.
Pollinator intraspecific body size variation and sociality influence their interactions with plants
Authors: Peralta Guadalupe , Resasco Julian , Worthy Sydney , Frost Carol M. , Guevara Angie T. , Manning Isabella , Cagnolo Luciano , Burkle Laura A.
Published: February 2024

Species morphological and behavioural traits are key determinants of which pollinator species interact with which plant species. However, individuals within species are not identical in their traits and this diversity could help us understand plant–pollinator interaction patterns.

Using three independent data sets, we assessed whether bee intraspecific body size variation (ITV) and sociality influenced pollinator interaction specialisation, intraspecific niche partitioning, centrality in the interaction network and phylogenetic diversity of the plants visited.

We found that solitary pollinators were more specialised in their interactions with plants and had lower intraspecific niche partitioning compared to social pollinators. Furthermore, solitary pollinators with higher ITV had higher centrality in the network and visited a higher phylogenetic diversity of plants compared to solitary species with lower ITV, whereas the opposite pattern emerged for social pollinators. Pollinator ITV did not differ between social and solitary bee species.

Our findings show that the effect of pollinator body size variation on plant–pollinator interactions depends on pollinator species sociality. Specifically, solitary pollinators with higher ITV and social pollinators with lower ITV seem to be the most important contributors to maintaining the evolutionary diversity of the plant community, and also the species with the largest potential to affect (via cascade effects) the entire plant–pollinator network.

Read the free Plain Language Summary for this article on the Journal blog.
Evolutionary and ecological trends in the Neotropical cycad genus Dioon (Zamiaceae): An example of success of evolutionary stasis
Authors: Gutiérrez‐Ortega José Said , Pérez‐Farrera Miguel Angel , Sato Mitsuhiko P. , Matsuo Ayumi , Suyama Yoshihisa , Vovides Andrew P. , Molina‐Freaner Francisco , Kajita Tadashi , Watano Yasuyuki
Published: February 2024

Cycads represent an example of the success of evolutionary stasis. Despite their early origin, they survived multiple events of mass extinction and diversified in modern tropical ecosystems during the Cenozoic without major changes in their morphology. What factors have allowed their persistence and diversification despite their conservative nature? We reviewed documentation on the micro‐ and macro‐evolutionary processes involved in the diversification of the Neotropical genus Dioon. Dioon comprises 18 species from varied habitats in Mexico and Honduras, and serves as a model to understand the patterns of cycad diversification. Here, we synthesize evidence reached from different fields, especially biogeography, phylogenetics, population ecology, and speciation, to propose a mechanism that can explain the current patterns of biodiversity in Dioon. At the macroevolutionary scale, a Paleogene origin for Dioon is more likely than an alternative hypothesis of a Neogene origin. Dioon lineages have dispersed along with the expansion of tropical forests throughout main mountain chains. Subsequently, climate change, and particularly aridification, promoted the fragmentation of the tropical forests, allowing the main Dioon clades to evolve in isolation at distinct biogeographic regimes. At the microevolutionary scale, low seed dispersal capability, stochastic demographic processes, and niche conservatism restrict the lineages to isolate themselves at narrow habitats, promoting local adaptation in populations. Local adaptation seems to be a process achieved through many generations under stabilizing selection. Altogether, these processes shaped the diversification in Dioon. This review attempts to stimulate further research on cycads and other biological groups that have diversified despite their apparent evolutionary stasis.
Rewiring metabolic flux to simultaneously improve malate production and eliminate by‐product succinate accumulation by Myceliophthora thermophila
Authors: Gu Shuying , Wu Taju , Zhao Junqi , Sun Tao , Zhao Zhen , Zhang Lu , Li Jingen , Tian Chaoguang
Published: February 2024

Although a high titre of malic acid is achieved by filamentous fungi, by‐product succinic acid accumulation leads to a low yield of malic acid and is unfavourable for downstream processing. Herein, we conducted a series of metabolic rewiring strategies in a previously constructed Myceliophthora thermophila to successfully improve malate production and abolish succinic acid accumulation. First, a pyruvate carboxylase CgPYC variant with increased activity was obtained using a high‐throughput system and introduced to improve malic acid synthesis. Subsequently, shifting metabolic flux to malate synthesis from mitochondrial metabolism by deleing mitochondrial carriers of pyruvate and malate, led to a 53.7% reduction in succinic acid accumulation. The acceleration of importing cytosolic succinic acid into the mitochondria for consumption further decreased succinic acid formation by 53.3%, to 2.12 g/L. Finally, the importer of succinic acid was discovered and used to eliminate by‐product accumulation. In total, malic acid production was increased by 26.5%, relative to the start strain JG424, to 85.23 g/L and 89.02 g/L on glucose and Avicel, respectively, in the flasks. In a 5‐L fermenter, the titre of malic acid reached 182.7 g/L using glucose and 115.8 g/L using raw corncob, without any by‐product accumulation. This study would accelerate the industrial production of biobased malic acid from renewable plant biomass.
Human myofiber‐enriched aging‐induced lncRNAFRAIL1 promotes loss of skeletal muscle function
Authors: Miller Matthew J. , Gries Kevin J. , Marcotte George R. , Ryan Zachary , Strub Matthew D. , Kunz Hawley E. , Arendt Bonnie K. , Dasari Surendra , Ebert Scott M. , Adams Christopher M. , Lanza Ian R.
Published: February 2024

The loss of skeletal muscle mass during aging is a significant health concern linked to adverse outcomes in older individuals. Understanding the molecular basis of age‐related muscle loss is crucial for developing strategies to combat this debilitating condition. Long noncoding RNAs (lncRNAs) are a largely uncharacterized class of biomolecules that have been implicated in cellular homeostasis and dysfunction across a many tissues and cell types. To identify lncRNAs that might contribute to skeletal muscle aging, we screened for lncRNAs whose expression was altered in vastus lateralis muscle from older compared to young adults. We identified FRAIL1 as an aging‐induced lncRNA with high abundance in human skeletal muscle. In healthy young and older adults, skeletal muscle FRAIL1 was increased with age in conjunction with lower muscle function. Forced expression of FRAIL1 in mouse tibialis anterior muscle elicits a dose‐dependent reduction in skeletal muscle fiber size that is independent of changes in muscle fiber type. Furthermore, this reduction in muscle size is dependent on an intact region of FRAIL1 that is highly conserved across non‐human primates. Unbiased transcriptional and proteomic profiling of the effects of FRAIL1 expression in mouse skeletal muscle revealed widespread changes in mRNA and protein abundance that recapitulate age‐related changes in pathways and processes that are known to be altered in aging skeletal muscle. Taken together, these findings shed light on the intricate molecular mechanisms underlying skeletal muscle aging and implicate FRAIL1 in age‐related skeletal muscle phenotypes.
Parental awareness and attitudes towards prevention of respiratory syncytial virus in infants and young children in Australia
Authors: Holland Charlie , Baker Megan , Bates Amber , Hughes Catherine , Richmond Peter C. , Carlson Samantha , Moore Hannah C.
Published: February 2024

Aim

To assess parental awareness of respiratory syncytial virus (RSV) and the level of acceptance of future RSV prevention strategies.

Methods

A cross‐sectional online survey was implemented targeting “future” and “current” parents of children aged ≤5 years in Australia.

Results

From 1992 eligible participants, two non‐mutually exclusive subgroups were formed: “current” parents (N = 1931) and “pregnant/planning” parents (N = 464: 403 also “current” parents and 61 “future” parents). Participants were predominantly (86.6%) aged 25–39 years and 68.5% with university education. The majority (89.6% current; 78.7% future) had heard of RSV. Of those, 64.2% (current) and 50.0% (future) were aware that pneumonia is associated with RSV; 71.8% (current) and 52.1% (future) were aware that bronchiolitis is associated with RSV. In multivariable logistic regression analyses, Australian‐born parents (aOR = 2.47 [95% CI: 1.48–4.12]), living in the eastern states (e.g., New South Wales: aOR = 6.15 [95% CI:2.10–18.04]), with a university‐level education (aOR = 2.61 [95% CI:1.38–4.94]) and being a current parent (aOR = 12.26 [95% CI:2.82–53.28]) were associated with higher RSV awareness. There was a high level of acceptance for maternal vaccines (future: 79.3%) and infant immunisation (all: 81.7%).

Conclusion

While RSV awareness and immunisation acceptance were high, there was limited knowledge of severity of RSV, especially in future parents. Education campaigns need to be developed to increase RSV knowledge.
The PROPHER study: patient‐reported outcomes after parastomal hernia treatment—a prospective international cohort study
Authors:   PROPHER Study Collaborating Group
Published: February 2024

Aim

A significant proportion of stoma patients develop a parastomal hernia (PSH), with reported rates varying widely from 5% to 50% due to heterogeneity in the definition and mode of diagnosis. PSHs are symptomatic in 75% of these patients, causing a significant impact on quality of life due to issues with appliance fitting, leakage, skin excoriation and pain. They can also lead to emergency presentations with strangulation and obstruction. Evidence is lacking on how to select patients for surgical intervention or conservative treatment. In those who do undergo surgery, the best operation for a particular patient or PSH is not always clear and many options exist. The aim of this study is to assess the impact of an individual patient’s PSH treatment on their subsequent self‐reported outcomes including treatment success and quality of life.

Methods

This is a prospective international cohort study of PSH treatment, including both operative and non‐operative interventions. A global network of clinicians and specialist nurses will recruit 1000–1500 patients and centralize detailed information, their individual background and their PSH treatment, as well as short‐term outcomes up to 30 days. Patients will then provide their own outcomes data including quality of life and whether their treatment was successful, via a secure online system, at 3, 6 and 12 months. PROPHER will be run in two phases: an internal pilot phase of at least 10 hospitals from up to five countries, and a main phase of up to 200 hospitals from across the European Society of Coloproctology network.

Discussion

This study will provide a wealth of contemporaneous information which will improve our ability to counsel patients and facilitate improved selection of appropriate and personalized interventions for those with a PSH.
Comparing five equations to estimate glomerular filtration rate or creatinine clearance and assign individuals to KDIGO categories across the full age spectrum using real world data
Authors: Dagenais Simon , Radi Zaher , Burnham Janelle , Goodman Smita , Bell Griffith , Corrigan Brian , Corman Shelby , Friedman Gary
Published: February 2024

Five equations are commonly used by biopharma companies to estimate glomerular filtration rate (GFR) or creatinine clearance (CrCl) based on regulatory and stakeholder recommendations. Changes observed in GFR and/or CrCl can be challenging to interpret as participants transition between age strata, prompting changes in equations. This manuscript explores how GFR, CrCl, and the resulting Kidney Disease Improving Global Outcomes (KDIGO) categories of kidney function can change when different equations are used. We analyzed descriptively real‐world data (RWD) from 48 health care organizations in the United States to identify patients with data (age, sex, height, weight, serum biomarkers such as creatinine [Scr] and/or cystatin C [Scys]) sufficient to estimate GFR and/or CrCl. Five equations (Bedside Schwartz, Modified Schwartz, Cockcroft‐Gault, 2021 Chronic Kidney Disease‐Epidemiology Collaboration [CKD‐EPI] Scr, and 2021 CKD‐EPI Scr/Scys) were used to estimate GFR and/or CrCl and assign individuals to KDIGO categories (G1–G5). We identified 32,728 patients, including 378 infants (<2 years), 1191 younger children (2 to <6 years), 1891 older children (6 to <12 years), 3174 adolescents (12 to <18 years), 16,367 younger adults (18 to <65 years), and 9727 older adults (65+ years) with sufficient information to estimate kidney function. For patients greater than or equal to 2 years, estimated GFR and/or CrCl and KDIGO categories based on the 2021 CKD‐EPI Scr/Scys equation appeared similar to those based on currently recommended equations. RWD suggests the 2021 CKD‐EPI Scr/Scys equation could potentially be used to estimate GFR in individuals aged 2 years and older; more research is needed to confirm these findings.
Some patients with type 2 diabetes may benefit from intensive glycaemic and blood pressure control: A post‐hoc machine learning analysis of ACCORD trial data
Authors: Jiao Tianze , Kianmehr Hamed , Lin Yilu , Li Piaopiao , Singh Ospina Naykky , Ghayee Hans K. , Ruzieh Mohammed , Fonseca Vivian , Shi Lizheng , Zhang Ping , Shao Hui
Published: February 2024

Aim

The action to control cardiovascular risk in diabetes (ACCORD) trial showed a neutral average treatment effect of intensive blood glucose and blood pressure (BP) controls in preventing major adverse cardiovascular events (MACE) in individuals with type 2 diabetes. Yet, treatment effects across patient subgroups have not been well understood. We aimed to identify patient subgroups that might benefit from intensive glucose or BP controls for preventing MACE.

Materials and methods

As a post‐hoc analysis of the ACCORD trial, we included 10 251 individuals with type 2 diabetes. We applied causal forest and causal tree models to identify participant characteristics that modify the efficacy of intensive glucose or BP controls from 68 candidate variables (demographics, comorbidities, medications and biomarkers) at the baseline. The exposure was (a) intensive versus standard glucose control [glycated haemoglobin (HbA1c) <6.0% vs. 7.0%‐7.9%], and (b) intensive versus standard BP control (systolic BP <120 vs. <140 mmHg). The primary outcome was MACE.

Results

Compared with standard glucose control, intensive one reduced MACE in those with baseline HbA1c <8.5% [relative risk (RR): 0.79, 95% confidence interval (CI): 0.67‐0.93] and those with estimated glomerular filtration rate ≥106 ml/min/1.73 m2 (RR: 0.74, 95% CI: 0.55‐0.99). Intensive BP control reduced MACE in those with normal high‐density lipoprotein levels (women >55 mg/dl, men >45 mg/dl; RR: 0.51, 95% CI: 0.34‐0.74). Risk reductions were not significant in other patient subgroups.

Conclusions

Our findings suggest heterogeneous treatment effects of intensive glucose and BP control and could provide biomarkers for future clinical trials to identify more precise HbA1c and BP treatment goals for individualized medicine.
Host‐dependent larval migration and parasitism risk in a polyphagous moth
Authors: Martel Véronique , Schlyter Fredrik , Sadek Medhat M. , Hegazi Esmat M. , Glaus Valentine , Hansson Bill S. , Anderson Peter
Published: February 2024

Female herbivorous insects are expected to oviposit on the host plant providing the best performance of the offspring. However, in some insects the larvae are mobile and are not totally dependent on the mother's choice. They can change host plant when conditions for development or exposure to natural enemies vary between individual plants within a patch. Here we study larval migration and preference between two host plants, cotton and alfalfa, in the Egyptian leafworm, Spodoptera littoralis (Boisduval) (Lepidoptera: Noctuidae). Previous studies have shown that although larval performance is better on cotton, females prefer to oviposit on alfalfa, and this preference corresponds to a higher survival of the eggs. In this study, S. littoralis larvae showed directed movement between host plants and were found to prefer alfalfa over cotton in field test in Egypt, as well as in laboratory selection of feeding site assays. To determine effects by natural enemies, the parasitism rates and various life‐history traits were measured for one larval parasitoid, Microplitis rufiventris Kokujev (Hymenoptera: Braconidae), on several host plants including cotton and clover (equivalent host plant to alfalfa). Overall, parasitism was higher on cotton and parasitoid performance (cocoon mass, adult longevity, and female egg load) was better on cotton compared to clover. This fact suggests an enemy‐free space on clover and alfalfa, as parasitism rate is higher on cotton, and the parasitoid performance is also better on cotton‐fed larvae.
Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity
Authors: Rigon Leonardo , Genovese Danilo , Piano Carla , Brunetti Valerio , Guglielmi Valeria , Cimmino Angelo Tiziano , Scala Irene , Citro Salvatore , Bentivoglio Anna Rita , Rollo Eleonora , Di Iorio Riccardo , Broccolini Aldobrando , Morosetti Roberta , Monforte Mauro , Frisullo Giovanni , Caliandro Pietro , Pedicelli Alessandro , Caricato Anselmo , Masone Giovanna , Calabresi Paolo , Marca Giacomo Della
Published: February 2024

Background and purpose

Post‐stroke movement disorders (PMDs) following ischemic lesions of the basal ganglia (BG) are a known entity, but data regarding their incidence are lacking. Ischemic strokes secondary to proximal middle cerebral artery (MCA) occlusion treated with thrombectomy represent a model of selective damage to the BG. The aim of this study was to assess the prevalence and features of movement disorders after selective BG ischemia in patients with successfully reperfused acute ischemic stroke (AIS).

Methods

We enrolled 64 consecutive subjects with AIS due to proximal MCA occlusion treated with thrombectomy. Patients were clinically evaluated by a movement disorders specialist for PMDs onset at baseline, and after 6 and 12 months.

Results

None of the patients showed an identifiable movement disorder in the subacute phase of the stroke. At 6 and 12 months, respectively, 7/25 (28%) and 7/13 (53.8%) evaluated patients developed PMDs. The clinical spectrum of PMDs encompassed parkinsonism, dystonia and chorea, either isolated or combined. In most patients, symptoms were contralateral to the lesion, although a subset of patients presented with bilateral involvement and prominent axial signs.

Conclusion

Post‐stroke movement disorders are not uncommon in long‐term follow‐up of successfully reperfused AIS. Follow‐up conducted by a multidisciplinary team is strongly advisable in patients with selective lesions of the BG after AIS, even if asymptomatic at discharge.
Surface Deformation and Seismicity Linked to Fluid Injection in the Raton Basin
Authors: Chambers Cameron R. , Brown Megan R. M. , Stokes Scott M. , Ge Shemin , Menezes Elizabeth A. , Tiampo Kristy F. , Sheehan Anne F.
Published: February 2024

It is suggested that in addition to seismicity deep fluid injection may cause surface uplift and subsidence in oil and gas‐producing regions. This study uses the Raton Basin as an example to investigate the hydromechanical processes of surface uplift and subsidence during wastewater injection. The Raton Basin, in southern central Colorado and northern central New Mexico, has experienced wastewater injection related to coalbed methane and gas production starting in 1994. In this study, we estimate the extent and magnitude of total vertical deformation in the Raton Basin from 1994 to 2020 and incremental deformation between the years 2017 to 2020. Results indicate a modeled uplift as much as 15 cm occurring between 1994 and 2020. Between 2017 and 2020, up to 3 cm of uplift occurred, largely near the northwestern injection wells. Most modeled uplift between 1994 and 2020 occurred near the southern wells, where the greatest cumulative volume of wastewater was injected. However, modeled subsidence occurred around the southern and eastern wells between 2017 and 2020, after the rate of injection decreased. Modeling indicates that while the magnitude of modeled uplift corresponds to cumulative injection volume and maximum rate in the long‐term, short‐term incremental deformation (uplift or subsidence) is controlled by changes in the rate of injection. The number of yearly earthquake events follows periods of rapid modeled uplifting throughout the Basin, suggesting that measurable surface deformation may be caused by the same injection‐induced pore pressure perturbations that initiate seismicity.
Saliva direct PCR protocol for HLA‐DQB1*02 genotyping
Authors: Carrillo Angeles , Manzur María Jimena , Juri Ayub Maximiliano
Published: February 2024

Celiac disease (CD) is an immune disorder, that is triggered by gluten ingestion in genetically predisposed individuals. The HLA‐DQB1*02 allele is the main predisposing genetic factor and a candidate for first‐line genotyping screening. We designed and validated a simple, DNA purification‐free PCR protocol directly from crude saliva, enabling the detection of the DQB1*02 allele. This assay also distinguishes homozygous from heterozygous carriers. We propose this method for use in mass screening and/or epidemiological studies.
Diabetes screening outcomes in youth presenting for paediatric weight management: A report of the Paediatric Obesity Weight Evaluation Registry
Authors: Kumar Seema , King Eileen , Binns Helen J. , Christison Amy , Cuda Suzanne E. , Yee Jennifer K. , Joseph Madeline , Kirk Shelley
Published: February 2024

Objective

Rising prevalence of obesity has led to increased rates of prediabetes and diabetes mellitus (DM) in children. This study compares rates of prediabetes and diabetes using two recommended screening tests (fasting plasma glucose [FPG] and haemoglobin A1c [HbA1c]).

Study Design

Data were collected prospectively from 37 multi‐component paediatric weight management programs in POWER (Paediatric Obesity Weight Evaluation Registry).

Results

For this study, 3962 children with obesity without a known diagnosis of DM at presentation and for whom concurrent measurement of FPG and HbA1c were available were evaluated (median age 12.0 years [interquartile range, IQR 9.8, 14.6]; 48% males; median body mass index 95th percentile [%BMIp95] 134% [IQR 120, 151]). Notably, 10.7% had prediabetes based on FPG criteria (100–125 mg/dL), 18.6% had prediabetes based on HbA1c criteria (5.7%–6.4%), 0.9% had DM by FPG abnormality (≥126 mg/dL) and 1.1% had DM by HbA1c abnormality (≥6.5%). Discordance between the tests was observed for youth in both age groups (10–18 years [n = 2915] and age 2–9 years [n = 1047]).

Conclusion

There is discordance between FPG and HbA1c for the diagnosis of prediabetes and DM in youth with obesity. Further studies are needed to understand the predictive capability of these tests for development of DM (in those diagnosed with prediabetes) and cardiometabolic risk.
“The third wing of the plane”: Fathers' perceptions of their role in the treatment process for daughters with eating disorders
Authors: O'Sullivan Hazel , Goodwin John , O'Malley Maria , Happell Brenda , O'Donovan Aine
Published: February 2024

Eating disorders are complex mental health conditions exacerbated by high mortality rates. International and national guidelines recommend family involvement in the treatment process, recognising the family as an important source of support to young people. Research suggests fathers engage less in the process compared to mothers. In studies exploring parental perspectives, most samples consisted of mothers, with fathers minimally represented. Few studies explore family involvement from the perspective of fathers. This study aimed to explore the experiences of fathers regarding their involvement in the treatment process. Qualitative descriptive methods were used, involving focus group interviews of seven fathers. Interviews were assisted by a semi‐structured interview guide. A qualitative content analysis approach was used to analyse the data regarding paternal experiences of engagement in the treatment process. Fathers understood the importance of the whole family working together but viewed mothers as taking a more central role in the treatment process, with fathers more at the periphery. Gender emerged as an influencing factor in paternal involvement, with mothers primarily taking on responsibility for the child with the eating disorder and fathers providing secondary support. Healthcare providers need to be aware of the contribution of gendered roles within the family system and consider this when working with families within the treatment process. Consequently, mental health nurses have an important role in encouraging fathers to become actively involved in the treatment process.
Effect of transconjunctival sutureless vitrectomy versus 20‐G vitrectomy on surgical wound closure in patients: A meta‐analysis
Authors: Huang Yan , Sun Jun , Wang Jimin , Zhang Xuedong , Chen Zhongpei
Published: February 2024

A meta‐analysis was conducted to evaluate the impact of transconjunctival sutureless vitrectomy (TSV) over 20 G vitrectomy on wound healing, as well as the requirements for closing the wound in order to treat vitreoretinal diseases. Among the 500 cases who had been treated with vitrectomy to September 2023, 250 were treated by transconjunctiva without vitrectomy and 250 were treated with 20 G vitrectomy. The odds ratio (OR) and mean difference (MD) of 95% confidence interval (CI) were computed to evaluate the influence of wound opening and closing on vitrectomy diseases. The evaluation of vitreoretinal diseases was performed with either a random‐or fixed‐effect model, which involved TSV compared to 20 G vitrectomy. Compared to 20 G vitrectomy, the opening time of the wound in TSV was less (MD, −2.03; 95% CI, −2.87, −1.19; p < 0.0001); Compared to 20 G vitrectomy, the closing time of the wound was less (MD, −4.84; 95% CI, −6.38, −3.03; p < 0.0001); Nevertheless, there were no statistically significant differences in the incidence of vitreous haemorrhage after TSV surgery compared with 20 G vitrectomy (OR, 0.74; 95% CI, 0.25, 2.18; p = 0.59). TSV vitrectomy can shorten the duration of the operation and speed up the healing of the wound. It is suggested that additional studies be carried out with a larger sample size in order to verify this conclusion.