bluuebunny/crossref_metadata_2025 huggingface dataset:
Boron Oxide Enhancing Stability of MoS2 Anode Materials for Lithium-Ion Batteries
Authors: Nguyen Thang Phan , Kim Il Tae
Published: March 2022

Molybdenum disulfide (MoS2) is the most well-known transition metal chalcogenide for lithium storage applications because of its simple preparation process, superior optical, physical, and electrical properties, and high stability. However, recent research has shown that bare MoS2 nanosheet (NS) can be reformed to the bulk structure, and sulfur atoms can be dissolved in electrolytes or form polymeric structures, thereby preventing lithium insertion/desertion and reducing cycling performance. To enhance the electrochemical performance of the MoS2 NSs, B2O3 nanoparticles were decorated on the surface of MoS2 NSs via a sintering technique. The structure of B2O3 decorated MoS2 changed slightly with the formation of a lattice spacing of ~7.37 Å. The characterization of materials confirmed the formation of B2O3 crystals at 30% weight percentage of H3BO3 starting materials. In particular, the MoS2_B3 sample showed a stable capacity of ~500 mAh·g−1 after the first cycle. The cycling test delivered a high reversible specific capacity of ~82% of the second cycle after 100 cycles. Furthermore, the rate performance also showed a remarkable recovery capacity of ~98%. These results suggest that the use of B2O3 decorations could be a viable method for improving the stability of anode materials in lithium storage applications.
Relationship of Mineralogical Composition to Thermal Expansion, Spectral Reflectance, and Physico-Mechanical Aspects of Commercial Ornamental Granitic Rocks
Authors: Alzahrani Abdullah M. , Lasheen El Saeed R. , Rashwan Mohammed A.
Published: March 2022

The aim of the present study is to link the thermal expansion, spectral reflectance, and physico-mechanical aspects of different types of commercial granitic rocks with their mineralogical and chemical composition. The granitic rock types were characterized using several analyses, including petrography, chemical, mineralogical, and thermo-gravimetrical analysis using XRF, XRD, and TG/DTG/DSC techniques. The rock types were subjected to several performance tests, such as tests of their thermal expansion, spectral reflectance, and physico-mechanical properties. The results revealed that quartz, albite, and potash feldspar with minor amounts of mica (biotite/muscovite/annite) are the main mineralogical constitutes, in addition to some alteration minerals, such as kaolinite, saussorite, and prehnite. The studied granitic rocks were classified as monzogranite/syenogranite of high K-calc-alkaline and peraluminous characters and are related to late- to post-collisional settings. The thermogravimetrical analysis revealed that the overall mass loss over the whole temperature range up to 978 °C did not exceed 3% of the initial weight for all studied rocks. The results of thermal expansion revealed that the maximum change in linear thermal expansion for all rock types did not exceed 0.015% of their initial lengths at an unusual air temperature of 50 °C. The spectral analysis revealed that iron and hydroxyl ions are the main spectral absorption features that appeared in the VIS-NIR and SWIR regions, in addition to the appearance of the common and distinctive absorption peaks of the main mineral composition. Furthermore, the spectral reflectance demonstrated that the granitic rock types of low iron oxide content achieved a high reflectivity percent in the VIS-NIR and SWIR spectral regions compared with those of high iron content. As a general trend, the granitic rock types of high iron content and/or lower quartz content exhibited a high performance regarding their physical and mechanical properties, such as water absorption, apparent porosity, bulk density, compressive strength, and abrasion resistance. The results of water absorption, density, strength, and abrasion resistance of the studied granitic rocks are in the range of 0.14–0.31%, 2582–2644 kg/m3, 77.85–222.75 MPa, and 26.27–55.91 Ha, respectively, conforming to the requirements of ornamental stones according to the ASTM standard.
Development of 2.45 GHz Semiconductor Microwave System for Combustion Ignition Enhancement and Failure Analysis
Authors: Ikeda Yuji
Published: March 2022

We developed a semiconductor microwave system to improve the ignition process in a combustion system. Under atmospheric pressure conditions, large plasma was successfully ignited by a 2.45 GHz microwave, and it is characterized in comparison with standard spark plug ignition and laser ignition. The size of the microwave power source was also effectively reduced with the minimal size (100 × 60 mm2) that could fit in the palm of a hand. We then prototyped a microwave plug with a diameter of 4 mm, which is smaller than the standard spark plugs for passenger cars. The design and electric field strength are discussed in detail. Combustion experiments were conducted using a motorcycle engine and an actual light vehicle, and significant fuel efficiency improvement was experimentally obtained. We investigated the wear of the plug caused by continuous operation, and efficiently improved the endurance by swinging the resonance frequency between 2.4 and 2.5 GHz. In a passenger car engine experiment using a flat panel igniter, significant fuel efficiency improvement was confirmed. Further failure analysis revealed that the ceramic was severely damaged by a large current surge.
Hot Isostatic Pressing for Fatigue Critical Additively Manufactured Ti-6Al-4V
Authors: Moran Terrence P. , Carrion Patricio E. , Lee Seungjong , Shamsaei Nima , Phan Nam , Warner Derek H.
Published: March 2022

The efficacy of hot isostatic pressing (HIP) for enhancing fatigue performance is investigated for additively manufactured (AM) Ti-6Al-4V. The limitations of HIP are probed by varying the initial material state via the selection of AM system, powder chemical composition, and process parameters. We demonstrate that the fatigue performance of HIP’d AM Ti-6Al-4V depends on the as-built quality of the material. Differences in common material attributes, such as pre-HIP defect populations or post-HIP microstructure morphology, are shown to be insufficient to explain the observed discrepancies in performance. This implies that additional microstructure attributes or localized deviations from the expected structure control the failure of this material. Finally, HIP parameters outside ASTM recommendations were explored, where a reduced temperature and high-pressure treatment yielded significantly improved fatigue performance.
Computation of the Electrical Resistance of a Low Current Multi-Spot Contact
Authors: Dankat Gideon Gwanzuwang , Dumitran Laurentiu Marius
Published: March 2022

In high complexity electrical systems such as those used in the automotive industries, electric connectors play an important role. The automotive industry is gradually shifting its attention to electric cars, which means more electrical connectors for sensors and data collection. A fault in connectors for sensors used in a vehicle can cause drastic damage to capital equipment and, in the worst case, the loss of life. The studies of faults or degradation of electrical contacts are essential for safety in vehicles and various industries. Although such faults can be due to numerous factors (such as dust, humidity, mechanical vibration, etc.) and some yet to be discovered, high contact resistance is the main factor causing erratic behavior of electrical contacts. This paper presents a study on the computation of electrical contact resistance of two metal conductors (in the form of a disk) with analytical relations and a numerical computation model based on the finite element method (FEM) in COMSOL Multiphysics. The contact spots were considered to have a higher electrical resistivity value (ρcs) than those of the two metal conductors (ρCu). Studies such as the one in view that is carried out on a microscopic level are often difficult to investigate experimentally. Therefore, with the help of a simplified numerical model, the consequences of the degradation of electrical contacts are investigated. To validate the FEM model, the numerical results were compared to those obtained from analytical models.
Self-Powered Electrical Impulse Chemotherapy for Oral Squamous Cell Carcinoma
Authors: Zhao Chaochao , Yang Yuan , Cui Xi , Shan Yizhu , Xue Jiangtao , Jiang Dongjie , Sun Jinyan , Li Na , Li Zhou , Yang Anping
Published: March 2022

Oral squamous cell carcinoma (OSCC) is a common oral cancer of the head and neck, which causes tremendous physical and mental pain to people. Traditional chemotherapy usually results in drug resistance and side effects, affecting the therapy process. In this study, a self-powered electrical impulse chemotherapy (EIC) method based on a portable triboelectric nanogenerator (TENG) was established for OSCC therapy. A common chemotherapeutic drug, doxorubicin (DOX), was used in the experiment. The TENG designed with zigzag structure had a small size of 6 cm × 6 cm, which could controllably generate the fixed output of 200 V, 400 V and 600 V. The electrical impulses generated by the TENG increased the cell endocytosis of DOX remarkably. Besides, a simply and ingeniously designed microneedle electrode increased the intensity of electric field (EF) between two adjacent microneedle tips compared with the most used planar interdigital electrode at the same height, which was more suitable for three-dimensional (3D) cells or tissues. Based on the TENG, microneedle electrode and DOX, the self-powered EIC system demonstrated a maximal apoptotic cell ratio of 22.47% and a minimum relative 3D multicellular tumor sphere (MCTS) volume of 160% with the drug dosage of 1 μg mL−1.
Characterization of Bioactive Colored Materials Produced from Bacterial Cellulose and Bacterial Pigments
Authors: Amorim Lúcia F. A. , Fangueiro Raul , Gouveia Isabel C.
Published: March 2022

A Bacterial Cellulose (BC) film was developed and characterized as a potential functional bioactive material. BC films, obtained from a microbial consortium of bacteria and yeast species, were functionalized with the bacterial pigment prodigiosin, produced by Serratia plymuthica, and flexirubin-type pigment, from Chryseobacterium shigense, which exhibit a wide range of biological properties. BC was successfully functionalized at 15% over the weight of the fiber at 40 °C during 60 min, and a color strength of 1.00 ± 0.01 was obtained for BC_prodigiosin and 0.38 ± 0.02 for BC_flexirubin-type pigment. Moreover, the BC films showed moderate hydrophilic character following alkaline treatment, which was maintained after both pigments were incorporated. The porosity and mechanical performance of the functionalized BC samples also remained unaffected. Furthermore, the BC samples functionalized with prodigiosin presented antibacterial activity and were able to inhibit the growth of pathogenic bacteria Staphylococcus aureus and Pseudomonas aeruginosa, with inhibition rates of 97.89 ± 0.60% and 85.12 ± 0.17%, respectively, while BC samples functionalized with flexirubin-type pigment exhibited the highest antioxidant activity, at 38.96 ± 0.49%. This research provides an eco-friendly approach to grant BC film-based material with color and advantageous bioactive properties, which can find application in several fields, especially for medical purposes.
Third-Generation Thermodynamic Descriptions for Ta-Cr and Ta-V Binary Systems
Authors: Zhang Enkuan , Xu Xinpei , Chen Yun , Tang Ying
Published: March 2022

The third-generation thermodynamic descriptions for Ta-Cr and Ta-V binary systems were performed to construct the reliable thermodynamic database for refractory high-entropy alloys (RHEAs) containing Laves phase. The third-generation Gibbs energy expressions of pure Cr and V in both solid and liquid phases were established, from which the thermodynamic properties and thermal vacancy can be well described. The thermodynamic descriptions of Ta-Cr and Ta-V over the whole composition and temperature regions were carried out based on the reviewed phase equilibria and thermodynamic data with the CALPHAD (CALculation of PHAse Diagrams) approach. Specifically, the thermodynamic parameters of C14 and C15 Laves phases were evaluated by combining the theoretically computed and experimentally measured thermodynamic properties as well as the semiempirical relations. The calculated phase diagrams and thermodynamic properties in Ta-Cr and Ta-V systems according to the present thermodynamic parameters had a nice agreement with the experimental data even down to 0 K, indicating the reliability of the present modeling.
Review on Preformed Crowns in Pediatric Dentistry—The Composition and Application
Authors: Sztyler Klaudia , Wiglusz Rafal J. , Dobrzynski Maciej
Published: March 2022

The purpose of this review is to compare and contrast the various types of preformed crowns that can be used to restore the primary teeth in children. Historically, preformed crowns have been widely available for the past 50 years. The clinical performance of preformed crowns has evolved to meet higher functional, mechanical, and aesthetic demands. Preformed crowns are available in a range of prefabricated sizes and shapes. Preformed crowns can vary depending on their properties, compounds, methods of preparation, and biocompatibility.
Combination of Pre- and Post-Mercerization Processes for Cotton Fabric
Authors: Lin Lina , Jiang Tiancheng , Liang Yonghong , Zhu Wenju , Inamdar Umarsharif Y. , Pervez Md. Nahid , Navik Rahul , Yang Xiaojun , Cai Yingjie , Naddeo Vincenzo
Published: March 2022

The dyeing process commonly deteriorates the luster of pre-mercerized cotton fabric, so post-mercerization processes are regularly applied to compensate for this. Herein, the influence of combining pre-mercerization with CS (caustic solution) or LA (liquid ammonia) and post-mercerization with CS or LA on the morphological structure, dyeing performance, tensile strength, and stiffness of woven cotton fabric was investigated. The crystallinity index values greatly decreased from 73.12 to 51.25, 58.73, 38.42, and 40.90% after the combined mercerization processes of LA–LA, CS–CS, LA–CS, and CS–LA, respectively. Additionally, the CS–LA- and LA–CS-treated samples exhibited a mixture of cellulose II and cellulose III allomorphs. The combined mercerization processing of cotton fabric resulted in slightly worse thermal stability. The LA and CS pre-mercerization processes increased the dye exhaustion, although the former decreased the dye fixation rate while the latter increased it by 4% for both dyes. The color strength of the dyed cotton fabric increased after both post-mercerization processes. Moreover, the fabric stiffness and mechanical properties showed an increasing trend due to the combined mercerization efforts.
A New Fungal Triterpene from the Fungus Aspergillus flavus Stimulates Glucose Uptake without Fat Accumulation
Authors: Li Dan-dan , Wang Ying , Kim Eun La , Hong Jongki , Jung Jee H.
Published: March 2022

Through activity-guided fractionation, a new triterpene (asperflagin, 1) was isolated as a PPAR-γ agonist from the jellyfish-derived fungus Aspergillus flavus. Asperflagin displayed selective and moderate transactivation effects on PPAR-γ in Ac2F rat liver cells. Based on further biological evaluation and molecular docking analysis, we postulated that asperflagin might function as a PPAR-γ partial agonist. This compound was calculated to display a typical PPAR-γ ligand–receptor interaction that is distinct from that of full agonistic antidiabetics such as rosiglitazone, and may retain the antidiabetic effect without accompanying weight gain. Weight gain and obesity are typical side effects of the PPAR-γ full agonist rosiglitazone, and lead to suboptimal outcomes in diabetic patients. Compared to rosiglitazone, asperflagin showed higher glucose uptake in HepG2 human liver cells at concentrations of 20 and 40 μM but induced markedly lower adipogenesis and lipid accumulation in 3T3-L1 preadipocytes. These results suggest that asperflagin may be utilized for further study on advanced antidiabetic leads.
Investigations on the Wound Healing Potential of Tilapia Piscidin (TP)2-5 and TP2-6
Authors: Liu Chia-Wen , Hsieh Chu-Yi , Chen Jyh-Yih
Published: March 2022

Wound healing is a highly orchestrated process involving many cell types, such as keratinocytes, fibroblasts and endothelial cells. This study aimed to evaluate the potential application of synthetic peptides derived from tilapia piscidin (TP)2, TP2-5 and TP2-6 in skin wound healing. The treatment of HaCaT keratinocytes with TP2-5 and TP2-6 did not cause cytotoxicity, but did enhance cell proliferation and migration, which could be attributed to the activation of epidermal growth factor receptor signaling. In CCD-966SK fibroblasts, although TP2-5 (31.25 μg/mL) and TP2-6 (125 μg/mL) showed cytotoxic effects, we observed the significant promotion of cell proliferation and migration at low concentrations. In addition, collagen I, collagen III, and keratinocyte growth factor were upregulated by the peptides. We further found that TP2-5 and TP2-6 showed pro-angiogenic properties, including the enhancement of human umbilical vein endothelial cell (HUVEC) migration and the promotion of neovascularization. In a murine model, wounds treated topically with TP2-5 and TP2-6 were reduced by day 2 post-injury and healed significantly faster than untreated wounds. Taken together, these findings demonstrate that both TP2-5 and TP2-6 have multifaceted effects when used as topical agents for accelerating wound healing.
Insights into Gradient and Anisotropic Pore Structures of Capiox® Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability
Authors: Fukuda Makoto , Tanaka Ryo , Sadano Kazunori , Tokumine Asako , Mori Tomohiro , Saomoto Hitoshi , Sakai Kiyotaka
Published: March 2022

When using the extracorporeal capillary membrane oxygenator (sample A) for ECMO treatments of COVID-19 severely ill patients, which is dominantly used in Japan and worldwide, there is a concern about the risk of SARS-CoV-2 scattering from the gas outlet port of the membrane oxygenator. Terumo has launched two types of membranes (sample A and sample B), both of which are produced by the microphase separation processes using polymethylpentene (PMP) and polypropylene (PP), respectively. However, the pore structures of these membranes and the SARS-CoV-2 permeability through the membrane wall have not been clarified. In this study, we analyzed the pore structures of these gas exchange membranes using our previous approach and verified the SARS-CoV-2 permeation through the membrane wall. Both have the unique gradient and anisotropic pore structure which gradually become denser from the inside to the outside of the membrane wall, and the inner and outer surfaces of the membrane have completely different pore structures. The pore structure of sample A is also completely different from the other membrane made by the melt-extruded stretch process. From this, the pore structure of the ECMO membrane is controlled by designing various membrane-forming processes using the appropriate materials. In sample A, water vapor permeates through the coating layer on the outer surface, but no pores that allow SARS-CoV-2 to penetrate are observed. Therefore, it is unlikely that SARS-CoV-2 permeates through the membrane wall and scatter from sample A, raising the possibility of secondary ECMO infection. These results provide new insights into the evolution of a next-generation ECMO membrane.
Versatile Encapsulation and Synthesis of Potent Liposomes by Thermal Equilibration
Authors: Roberts Steven A. , Lee Chaebin , Singh Shrishti , Agrawal Nitin
Published: March 2022

The wide-scale use of liposomal delivery systems is challenged by difficulties in obtaining potent liposomal suspensions. Passive and active loading strategies have been proposed to formulate drug encapsulated liposomes but are limited by low efficiencies (passive) or high drug specificities (active). Here, we present an efficient and universal loading strategy for synthesizing therapeutic liposomes. Integrating a thermal equilibration technique with our unique liposome synthesis approach, co-loaded targeting nanovesicles can be engineered in a scalable manner with potencies 200-fold higher than typical passive encapsulation techniques. We demonstrate this capability through simultaneous co-loading of hydrophilic and hydrophobic small molecules and targeted delivery of liposomal Doxorubicin to metastatic breast cancer cell line MDA-MB-231. Molecular dynamic simulations are used to explain interactions between Doxorubicin and liposome membrane during thermal equilibration. By addressing the existing challenges, we have developed an unparalleled approach that will facilitate the formulation of novel theranostic and pharmaceutical strategies.
Non-Ferrous Metals and PGM Recovery from Low-Grade Copper–Nickel Concentrate by Bioleaching and Further Cyanidation
Authors: Latyuk Elena , Melamud Vitaliy , Lavrinenko Anatoly , Makarov Dmitriy , Bulaev Aleksandr
Published: March 2022

The aim of the present work was to perform copper, nickel, and platinum group metals (PGMs) recovery from low-grade copper–nickel concentrate containing pyrrhotite, pentlandite, and chalcopyrite by bioleaching in stirred tank reactors in batch mode and subsequent cyanidation. The concentrate contained (%) Fe 32.7, Cu 0.7, Ni 2.3, Stotal 20.9, Ssulfide 17, 0.1 g/t Pt, and 1.35 g/t Pd. The bioleaching was performed at 30 and 40 °C using two different microbial consortia. At 30 °C, bioleaching was performed using mixed culture including Acidithiobacillus ferrivorans strains isolated from the sample of acid mine drainage from copper–nickel deposit. At 40 °C, bioleaching was performed using microbial population formed during long-term bioleaching of copper-zinc concentrate at 40 °C. Bioleaching was performed for 40 days at pulp density of 10% (solid to liquid ratio 1:10). At 30 °C, 70% Ni and 14% Cu were leached, while 72% Ni and 34% Cu were recovered in the solution at 40 °C. PGM were extracted from the concentrate and bioleaching residue obtained at 40 °C by cyanidation. Cyanidation made it possible to extract 5.5% Pt and 17.3% Pd from the concentrate and 37.8% Pt and 87.8% Pd from the bioleaching residue. Thus, it was shown that the concentrate studied might be processed using bioleaching and subsequent cyanidation to extract both non-ferrous metals and PGM.
Experimental Development of Transport Percussion Marks on Obsidian Clasts, Pilauco Site, Chilean Northwestern Patagonia
Authors: Madrigal Catalina , Lledó Haroldo , Fritte Daniel , Pino Mario
Published: March 2022

In the Pilauco site (40°34′11″ S, 73°06′17″ W; 13,570 ± 70–12,540 ± 90 14C year BP), a previous geochemical trace analysis suggested that the Puyehue-Cordón Caulle Volcanic Complex is the most likely source for obsidian and dacitic glass artifacts at Pilauco. It was hypothesized that the glassy rocks were probably collected from a pebble beach deposit, as deduced by the presence of crescentic percussion marks on the artefact cortexes. An experimental study was designed using pebble obsidian clasts. Bidirectional transport produced by the waves on a beach was imitated by an oscillating table, using time lapses equivalent to a transport of 0.7 to 20 km. One hundred clasts were randomly selected and marked. The morphological changes were registered, measured and photographed after seven sequential runs. At the end of the experiment at 20 km, the mass loss of rounded and fractured clasts was 5% and 11%, respectively. Crescent, circular, pseudo-circular and irregular percussion marks occurred in both types of clasts. In all cases, the crescent marks developed a pseudo-frosted surface appearance, giving a whiter tone that masks the black color of the obsidian, exactly as observed in the cortex of the artifacts knapped in dacitic glass at the Pilauco site. Thus, it is highly probable that the vitreous material was obtained from a beach sourced by the Puyehue-Cordón Caulle Volcanic Complex.
In Situ Visual Distribution of Gelsemine, Koumine, and Gelsenicine by MSI in Gelsemiumelegans at Different Growth Stages
Authors: Wu Zi-Han , Su Yi , Luo Zhou-Fei , Sun Zhi-Liang , Gong Zhi-Hong , Xiao Lang-Tao
Published: March 2022

The distribution of pharmatically important alkaloids gelsemine, koumine, and gelsenicine in Gelsemium elegans tissues is a hot topic attracting research attention. Regretfully, the in planta visual distribution details of these alkaloids are far from clear although several researches reported the alkaloid quantification in G. elegans by LC-MS/MS. In this study, mass imaging spectrometry (MSI) was employed to visualize the in situ visualization of gelsemine, koumine, and gelsenicine in different organs and tissues of G. elegans at different growth stages, and the relative quantification of three alkaloids were performed according to the image brightness intensities captured by the desorption electrospray ionization MSI (DESI-MSI). The results indicated that these alkaloids were mainly accumulated in pith region and gradually decreased from pith to epidermis. Interestingly, three alkaloids were found to be present in higher abundance in the leaf vein. Along with the growth and development, the accumulation of these alkaloids was gradually increased in root and stem. Moreover, we employed LC-MS/MS to quantify three alkaloids and further validated the in situ distributions. The content of koumine reached 249.2 μg/g in mature roots, 272.0 μg/g in mature leaves, and 149.1 μg/g in mature stems, respectively, which is significantly higher than that of gelsemine and gelsenicine in the same organ. This study provided an accurately in situ visualization of gelsemine, koumine, and gelsenicine in G. elegans, and would be helpful for understanding their accumulation in plant and guiding application.
Discrimination of Excited States of Acetylacetone through Theoretical Molecular-Frame Photoelectron Angular Distributions
Authors: Ponzi Aurora , Sapunar Marin , Došlić Nadja , Decleva Piero
Published: March 2022

Photoelectron angular distribution (PAD) in the laboratory frame for randomly oriented molecules is typically described by a single anisotropy parameter, the so-called asymmetry parameter. However, especially from a theoretical perspective, it is more natural to consider molecular photoionization by using a molecular frame. The molecular frame PADs (MFPADs) may be used to extract information about the electronic structure of the system studied. In the last decade, significant experimental efforts have been directed to MFPAD measurements. MFPADs are highly characterizing signatures of the final ionic states. In particular, they are very sensitive to the nature of the final state, which is embodied in the corresponding Dyson orbital. In our previous work on acetylacetone, a prototype system for studying intra-molecular hydrogen bond interactions, we followed the dynamics of the excited states involved in the photoexcitation–deexcitation process of this molecule. It remains to be explored the possibility of discriminating between different excited states through the MFPAD profiles. The calculation of MFPADs to differentiate excited states can pave the way to the possibility of a clear discrimination for all the cases where the recognition of excited states is otherwise intricate.
The 10th Anniversary of Nanomaterials—Recent Advances in Environmental Nanoscience and Nanotechnology
Authors: Yentekakis Ioannis V.
Published: March 2022

As a result of the rapid growth of nanoscience and nanotechnology, including advanced methods of fabrication and characterization of nanostructured materials, great progress has been made in many fields of science, not least in environmental catalysis, energy production and sustainability [...]
Long-Term Aging of Concentrated Aqueous Graphene Oxide Suspensions Seen by Rheology and Raman Spectroscopy
Authors: Gyarmati Benjámin , Farah Shereen , Farkas Attila , Sáfrán György , Voelker-Pop Loredana Mirela , László Krisztina
Published: March 2022

Today, graphene oxide (GO) has gained well-deserved recognition, with its applications continuing to increase. Much of the processing of GO-based devices occurs in a dispersed form, which explains the commercialization of GO suspensions. Aging of these suspensions can, however, affect the shelf life and thus their application potential. Aging of GO preparations is often acknowledged, but no longer-term systematic study has been reported on the alteration of GO suspensions. This paper investigates high-concentration (10 mg/mL) aqueous GO suspensions over a 2-year time scale. In addition to steady shear tests, the dynamic behavior of the suspensions was studied in more detail by transient shear and frequency sweep measurements. Both the viscosity and the dynamic moduli increased with age, particularly within the first year. The results of the complementary Raman spectroscopic studies indicate that the change in the rheological behavior with aging results from a slow oxidation process occurring in the highly acidic aqueous medium during the relatively long-term storage. The (over)oxidized layers peel off spontaneously or are removed by high shear stress, resulting in increased viscosity, as it was corroborated by XRD and XPS.
Effect of Substrate Temperature on Morphological, Structural, and Optical Properties of Doped Layer on SiO2-on-Silicon and Si3N4-on-Silicon Substrate
Authors: Kamil Suraya Ahmad , Jose Gin
Published: March 2022

A high concentration of Er3+ without clustering issues is essential in an Er-doped waveguide amplifier as it is needed to produce a high gain and low noise signal. Ultrafast laser plasma doping is a technique that facilitates the blending of femtosecond laser-produced plasma from an Er-doped TeO2 glass with a substrate to form a high Er3+ concentration layer. The influence of substrate temperature on the morphological, structural, and optical properties was studied and reported in this paper. Analysis of the doped substrates using scanning electron microscopy (SEM) confirmed that temperatures up to approximately 400 °C are insufficient for the incoming plasma plume to modify the strong covalent bonds of silica (SiO2), and the doping process could not take place. The higher temperature used caused the materials from Er-doped tellurite glass to diffuse deeper (except Te with smaller concentration) into silica, which created a thicker film. SEM images showed that Er-doped tellurite glass was successfully diffused in the Si3N4. However, the doping was not as homogeneous as in silica.
High-Salt Diet Induces Depletion of Lactic Acid-Producing Bacteria in Murine Gut
Authors: Hamad Ibrahim , Cardilli Alessio , Côrte-Real Beatriz F. , Dyczko Aleksandra , Vangronsveld Jaco , Kleinewietfeld Markus
Published: March 2022

Dietary habits are amongst the main factors that influence the gut microbiome. Accumulating evidence points to the impact of a high-salt diet (HSD) on the composition and function of the intestinal microbiota, immune system and disease. In the present study, we thus investigated the effects of different NaCl content in the food (0.03%/sodium deficient, 0.5%/control, 4% and 10% NaCl) on the gut microbiome composition in mice. The bacterial composition was profiled using the 16S ribosomal RNA (rRNA) gene amplicon sequencing. Our results revealed that HSD led to distinct gut microbiome compositions compared to sodium-deficient or control diets. We also observed significant reduction in relative abundances of bacteria associated with immuno-competent short-chain fatty acid (SCFA) production (Bifidobacterium, Faecalibaculum, Blautia and Lactobacillus) in HSD-fed mice along with significant enrichment of Clostridia, Alistipes and Akkermansia depending on the sodium content in food. Furthermore, the predictive functional profiling of microbial communities indicated that the gut microbiota found in each category presents differences in metabolic pathways related to carbohydrate, lipid and amino acid metabolism. The presented data show that HSD cause disturbances in the ecological balance of the gastrointestinal microflora primarily through depletion of lactic acid-producing bacteria in a dose-dependent manner. These findings may have important implications for salt-sensitive inflammatory diseases.
Social Determinants and Self-Care for Making Good Treatment Decisions and Treatment Participation in Older Adults: A Cross-Sectional Survey Study
Authors: Okpalauwaekwe Udoka , Li Chih-Ying , Tzeng Huey-Ming
Published: March 2022

Background: Community-dwelling adults who can perform self-care behaviors related to making treatment decisions and participating in treatment have been found to use less emergency care. In this exploratory study, we examined the relationships in older adults between five social determinants (urban/rural residence, sex, age, marital status, and education) and the perceived importance, desirability, and ability to perform 11 self-care behaviors related to making good treatment decisions and participating in treatment. Methods: This cross-sectional study surveyed 123 community-dwelling older adults living in the southern United States in 2015–2016. All participants were 65 years or older. Data were collected using the Patient Action Inventory for Self-Care and analyzed using descriptive, univariate, and multivariate logistic regression analyses. Results: The social determinants (identified as barriers) of self-care behaviors related to making good treatment decisions and participating in treatment were: having less than a high school education, being 75 years or older, and being separated from a spouse. Sex and residence were found to be neither barriers nor facilitators. Conclusions: Our findings suggest that, in older adults, attending to the needs related to health literacy education and improving social support might increase self-care behaviors related to making good treatment decisions and participating in treatment. Future research will compare the differences across diverse populations to validate our study findings.
Plant Terpenoids as Hit Compounds against Trypanosomiasis
Authors: Durão Raquel , Ramalhete Cátia , Madureira Ana Margarida , Mendes Eduarda , Duarte Noélia
Published: March 2022

Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites.
In Vitro & In Vivo Studies on Identifying and Designing Temporin-1CEh from the Skin Secretion of Rana chensinensis as the Optimised Antibacterial Prototype Drug
Authors: Ye Zhuming , Zhou Xiaowei , Xi Xinping , Zai Yu , Zhou Mei , Chen Xiaoling , Ma Chengbang , Chen Tianbao , Wang Lei , Kwok Hang Fai
Published: March 2022

Amphibian skin secretion is an ideal source of antimicrobial peptides that are difficult to induce drug resistance to due to their membrane-targeting mechanism as a new treatment scheme. In this study, a natural antimicrobial peptide Temporin-1CEh was identified by molecular cloning and mass spectrometry from the skin secretions of the Chinese forest frog (Rana chensinensis). Through the study of the structure and biological activity, it was found that Temporin-1CEh was a helical peptide from the Temporin family, and possessed good anti-Gram-positive bacteria activity through the mechanism of membrane destruction. Seven analogues were further designed to obtain broad-spectrum antimicrobial activity and higher stability in different physiological conditions. The results showed that T1CEh-KKPWW showed potent antibacterial activity with significantly increasing the activity against Gram-negative bacteria in vitro and in vivo with low haemolysis. In addition, T1CEh-KKPWW2 showed high sensitivity to the pH, serum or salts conditions, which applied a branched structure to allow the active units of the peptide to accumulate. Even though the haemolytic activity was increased, the stable antibacterial activity made this novel analogue meet the conditions to become a potential candidate in future antimicrobial and antibiofilm applications.
The Value of Bead Coating in the Manufacturing of Amorphous Solid Dispersions: A Comparative Evaluation with Spray Drying
Authors: Boel Eline , Reniers Felien , Dehaen Wim , Van den Mooter Guy
Published: March 2022

Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers potential advantages regarding the minimization of physical stability issues, there is still a lack of in-depth understanding of the bead coating process and its value in relation to spray drying. Therefore, bead coating and spray drying were both evaluated for their ability to manufacture high drug-loaded ASDs and for their ability to generate physically stable formulations. For this purpose, naproxen (NAP)–poly(vinyl-pyrrolidone-co-vinyl acetate) (PVP-VA) was selected as an interacting drug–polymer model system, whilst naproxen methyl ester (NAPME)–PVP-VA served as a non-interacting model system. The solvent employed in this study was methanol (MeOH). First, a crystallization tendency study revealed the rapid crystallization behavior of both model drugs. In the next step, ASDs were manufactured with bead coating as well as with spray drying and for each technique the highest possible drug load that still results in an amorphous system was defined via a drug loading screening approach. Bead coating showed greater ability to manufacture high drug-loaded ASDs as compared to spray drying, with a rather small difference for the interacting drug–polymer model system studied but with a remarkable difference for the non-interacting system. In addition, the importance of drug–polymer interactions in achieving high drug loadings is demonstrated. Finally, ASDs coated onto pellets were found to be more physically stable in comparison to the spray dried formulations, strengthening the value of bead coating for ASD manufacturing purposes.
Investigating Nutrient Supply Effects on Plant Growth and Seed Nutrient Content in Common Bean
Authors: Smith Millicent R. , Reis Hodecker Barbara Elias , Fuentes David , Merchant Andrew
Published: March 2022

Low soil fertility commonly limits growth and yield production of common bean (Phaseolus vulgaris L.) in tropical regions. Impacts of nutrient limitations on production volume are well studied and are a major factor in reducing crop yields. This study characterised the impact of reduced nutrient supply on carbon assimilation and nutrient content of leaf, phloem sap and reproductive tissues of common bean grown in a controlled environment in order to detect chemical markers for changes in nutritional content. Leaf gas exchange measurements were undertaken over plant development to characterise changes to carbon assimilation under reduced nutrient supply. Samples of leaf, phloem sap and pod tissue of common bean were analysed for carbon isotope discrimination, mineral nutrient content, and amino acid concentration. Despite declines in nutrient availability leading to decreased carbon assimilation and reductions in yield, amino acid concentration was maintained in the pod tissue. Common bean can maintain the nutritional content of individual pods under varying nutrient availabilities demonstrating the resilience of processes determining the viability of reproductive tissues.
The Influence of Fly Ash on the Foaming Behavior and Flame Retardancy of Polyurethane Grouting Materials
Authors: Zhang Sitong , Liu Wenying , Yang Kaijie , Yu Wenwen , Zhu Fengbo , Zheng Qiang
Published: March 2022

Polyurethane (PU) grouting material has been widely utilized to control water inrush in mining fields. However, the application has been limited by its high cost and poor flame retardancy. Here, we use the fly ash (FA), a waste from coal of the iron-making industry and power plants, as a partial replacement of conventional filler in PU grouting materials to reduce the production cost and the environmental pollution of FA. The surface-modified FA-filled PU (PU/FA) composites were prepared by room-temperature curing. The effects of FA contents (φ) on the structure, foaming behavior, thermal stability, mechanical properties, hydrophobic properties, and flammability of PU grouting materials were examined. Results showed that the higher the φ, the more porous the PU/FA composites are, resulting in a lower density and lower mechanical properties. The relationship between the compression modulus E and the density ρ of the PU/FA composites was E ∝ ρ1.3. In addition, the surface-modified FA improved the compatibility between the hard and soft segment of PU in the PU/FA composite, giving the composites enhanced thermal stability, high hydrophobicity, and flammability resistance.
Biopackaging Potential Alternatives: Bioplastic Composites of Polyhydroxyalkanoates and Vegetal Fibers
Authors: Gómez-Gast Natalia , López Cuellar Ma Del Rocío , Vergara-Porras Berenice , Vieyra Horacio
Published: March 2022

Initiatives to reduce plastic waste are currently under development worldwide. As a part of it, the European Union and private and public organizations in several countries are designing and implementing regulations for single-use plastics. For example, by 2030, plastic packaging and food containers must be reusable or recyclable. In another approach, researchers are developing biopolymers using biodegradable thermoplastics, such as polyhydroxyalkanoates (PHAs), to replace fossil derivatives. However, their production capacity, high production costs, and poor mechanical properties hinder the usability of these biopolymers. To overcome these limitations, biomaterials reinforced with natural fibers are acquiring more relevance as the world of bioplastics production is increasing. This review presents an overview of PHA–vegetal fiber composites, the effects of the fiber type, and the production method’s impact on the mechanical, thermal, barrier properties, and biodegradability, all relevant for biopackaging. To acknowledge the behaviors and trends of the biomaterials reinforcement field, we searched for granted patents focusing on bio-packaging applications and gained insight into current industry developments and contributions.
Experimental and Numerical Investigation of a Lattice Structure for Energy Absorption: Application to the Design of an Automotive Crash Absorber
Authors: Boursier Niutta Carlo , Ciardiello Raffaele , Tridello Andrea
Published: March 2022

In this work, an experimental and numerical analysis of a lattice structure for energy absorption was carried out. The goal was to identify the most influencing parameters of the unit cell on the crushing performances of the structure, thus guiding the design of energy absorbers. Two full factorial plans of compression tests on cubic specimens of carbon nylon produced by fused deposition modeling (FDM) were performed. The factors were the beam diameter and the number of unit cells. In the first factorial plan, the specimen volume is constant and the dimensions of the unit cell are varied, while the second factorial plan assumes a constant size of the unit cell and the volume changes in accordance with their number. The results showed that the specific energy absorption increases with the diameter of the beam and decreases with the size of the unit cell. Based on these results, a crash absorber for the segment C vehicle was designed and compared with the standard component of the vehicle made of steel. In addition to a mass reduction of 25%, the improved crushing performances of the lattice structure are shown by the very smooth force-displacement curve with limited peaks and valleys.
Restoration of Individual Tree Missing Point Cloud Based on Local Features of Point Cloud
Authors: Cao Wei , Wu Jiayi , Shi Yufeng , Chen Dong
Published: March 2022

LiDAR (Light Detection And Ranging) technology is an important means to obtain three-dimensional information of trees and vegetation. However, due to the influence of scanning mode, environmental occlusion and mutual occlusion between tree canopies and other factors, a tree point cloud often has different degrees of data loss, which affects the high-precision quantitative extraction of vegetation parameters. Aiming at the problem of a tree laser point cloud being missing, an individual tree incomplete point cloud restoration method based on local features of the point cloud is proposed. The L1-Median algorithm is used to extract key points of the tree skeleton, then the dominant direction of skeleton key points and local point cloud density are calculated, and the point cloud near the missing area is moved based on these features to gradually complete the incomplete point cloud compensation. The experimental results show that the above repair method can effectively repair the incomplete point cloud with good robustness and can adapt to the individual tree point cloud with different geometric structures and correct the branch topological connection errors.
Estimating Evapotranspiration over Heterogeneous Surface with Sentinel-2 and Sentinel-3 Data: A Case Study in Heihe River Basin
Authors: Lian Ting , Xin Xiaozhou , Peng Zhiqing , Li Fugen , Zhang Hailong , Yu Shanshan , Liu Huiyuan
Published: March 2022

Evapotranspiration (ET) is an important part of surface–atmosphere interactions, connecting the transfer of matter and energy. Land surface heterogeneity is a natural attribute of the Earth’s surface and is an inevitable problem in calculating ET with coarse resolution remote sensing data, which results in significant error in the ET estimation. This study aims to explore the effect and applicability of the evaporative fraction and area fraction (EFAF) method for correcting 1 km coarse resolution ET. In this study we use the input parameter upscaling (IPUS) algorithm to estimate energy fluxes and the EFAF method to correct ET estimates. Five ground stations in the midstream and downstream regions of the Heihe River Basin (HRB) were used to validate the latent heat flux (LE) calculated by the IPUS algorithm and EFAF method. The evaluation results show that the performance of the EFAF method is superior to that of the IPUS algorithm, with the coefficient of determination (R2) increasing, the root mean square error (RMSE) decreasing, and the mean bias error (MBE) decreasing by 17 W/m2 on average. In general, the EFAF method is suitable for correcting the deviation in LE estimated based on Sentinel data caused by land surface heterogeneity and can be applied to obtain accurate estimates of ET.