bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi Literatur Perbandingan Keanekaragaman Kelelawar di Pulau Kalimantan dan Jawa
Authors: Saiful Muhammad , Febrina Halimah Syifa , Fauzan Muhammad , Maisa Diva Rara Vidyani , Maolani Astri , Suryanda Ade , Dewahrani Yulilina Retno
Published: August 2022

Kelelawar merupakan organisme yang berperan penting bagi kelangsungan kehidupan manusia dan kelestarian ekosistem. Sayangnya akhir-akhir ini populasi kelelawar di dunia mengalami penurunan. Faktor utama yang menyebabkan hal ini terjadi adalah kehilangan habitat akibat degradasi habitat. Penelitian ini bertujuan untuk melihat perbandingan keanekaragaman kelelawar di pulau Jawa dan Kalimantan. Penelitian dilaksanakan pada bulan Juli 2021 dengan metode studi literatur dengan data yang diambil dari beberapa artikel mengenai keanekaragaman kelelawar di pulau Jawa dan Kalimantan. Berdasarkan penelitian yang sudah dilakukan perbandingan keanekaragaman kelelawar di pulau Jawa dan Kalimantan diketahui bahwa pulau Kalimantan memiliki keanekaragaman kelelawar yang lebih tinggi daripada kelelawar di pulau Jawa berdasarkan indeks keanekaragaman kelelawar di kedua pulau. Perbedaan tinggi indeks keanekaragaman kelelawar ini disebabkan karena pulau Kalimantan memiliki luas hutan yang lebih besar dibandingkan pulau Jawa yang berpengaruh juga terhadap jumlah pakan yang tersedia bagi kelelawar untuk hidup.
Penggunaan Media Pembelajaran Berbasis E-Learning Terhadap Motivasi Belajar Biologi Siswa
Authors: Aroyandini Elvara Norma , Anfa Qurrotul , Firanti Annisa
Published: August 2022

One of the main problems in learning biology is the lack of student motivation in learning. This is partly due to the lack of learning media that can visualize learning more exciting and easily understood by students without multiple interpretations due to not seeing the real learning object. Therefore, this study was conducted to determine the types or variants of e-learning media in biology learning and analyze the background problems based on previous studies of previous studies. The method used in this research is a literature study with a pure research style. The data collection technique is a library research technique with data sources in reference books and 37 articles relevant to research topics in the period 2013 to 2020. Data analysis is carried out using content analysis and exploration models, where the analysis results are used as a basis for interpretation. Based on the discussion that has been done, it can be concluded that this study found 15 types of e-learning media in biology learning that can increase student learning motivation, where the most influential media are android applications, interactive multimedia, animation, and original el-learning. In addition, it was also found that the background that caused the students' low motivation to learn was due to the lack of technology development in biology learning media, the lack of visualization of various objects of biology learning, and the lack of student interest in participating in biology learning.
Karakterisasi Mikoriza di Kawasan Hutan Desa Fatusene Kecamatan Miomaffo Timur Kabupaten Timor Tengah Utara
Authors: Naisumu Yolanda Getrudis , Binsasi Remigius
Published: August 2022

The existence of allegations about the presence of various mycorrhizae in the forest area of Fatusene Village, East Miomaffo District, North Central Timor Regency, is a benchmark for assessing the characterization of mycorrhizae in the area. The purpose of this study was to isolate and identify mycorrhizae in the forest area of Fatusene Village, East Miomaffo District, North Central Timor Regency. Mycorrhizal identification begins with sampling the soil under the tree stands using the quadratic method. Soil samples were taken randomly at three points per observation plot with a depth of 0-30 cm from the base of the tree trunk. Separation of spores from soil samples was carried out using a wet sieve technique. Data analysis was carried out descriptively by identifying morphological characters including the shape and color of the spores. The results of mycorrhizal research found in the research location of the forest area of Fatusene Village are endomycorrhizal types, especially arbuscular vesicles. Characterization of mycorrhizal spores showed that there were three different spore genera in soil samples, namely the genus Glomus, Gigaspora and Acaulospora. The three genus found in the soil samples at the study location were present in each dominant tree with different numbers of individuals. The spores of the three mycorrhizal genus found at the study site were 65 spores, with the distribution of 35 spores genus Glomus, 20 spores genus Acaulospora and 10 spores the genus Gigaspora. The characters the genus glomus are round, slightly round, oval and brown and dark brown in, have hyphae and are equipped with oily fluid spots on cook spores. The characters the genus Acaulospora are round and oval in shape, blackish brown in color, brownish red and brownish yellow, have several layers of cell walls, one of which is dark in color. The characters the genus Gigaspora are irregular in shape, somewhat round and round, yellow, brownish yellow, to yellowish brown, large in size and black spore walls. Conclusion The mycorrhizae found in the study site were endomycorrhizal, especially arbuscular vesicles which consisted of 3 genera, namely Glomus, Acaulospora and Gigaspora. The characters of the genus glomus are round to oval in shape, dark brown in color, have hyphae and spotting of oil. The characters the genus Acaulospora are round and oblong, brownish yellow in color, have several layers of cell walls. The genus Gigaspora is slightly round and round, yellowish brown in color, large and black spore walls.
Pengaruh Pembelajaran Daring Menggunakan Model Problem-based Learning (PBL) Terhadap Hasil Belajar Siswa
Authors: Cahyani Dwi , Setiadi Anandita Eka , Qurbaniah Mahwar
Published: August 2022

Most students consider the excretory system material to be difficult to understand so that students often only memorize it in their learning. Teachers generally use the Teacher Centered Learning (TCL) model in online learning. This study aims to determine the effect of online learning during the pandemic using the Problem-Based Learning (PBL) model on student learning outcomes. The research was conducted in class XI SMA Islamiyah Pontianak. The research method uses Quasi Experiment. The study used class XI IPS 2 as the experimental class and class XI IPS 1 as the control class which was selected using purposive sampling technique. Data was collected by means of learning outcomes tests before and after learning. The research data were analyzed using N-Gain. The results showed that in the experimental class the N-Gain score was 0.46 (medium category), while in the control class the N-Gain score was 0.19 (low category). Based on the results of the study, it was concluded that there was an effect of the PBL learning model on the learning outcomes of the XI grade students of SMA Islamiyah Pontianak.
Psychological Processes in Language Learning and Teaching: Methods and Approaches of Psycholinguistics
Authors: Dey Manna , Sawalmeh Murad Hassan
Published: August 2022

The field of psycholinguistics has produced many hypotheses which explain how a person speaks and understands the language spoken or written. In the area of language, instruction theories have been employed. In designing language education approaches, several professionals adopt them as their fundamental theories. It is called a method of psycholinguistics. The psycholinguistic method considers learning as an individual cognitive process that takes place within the individual and then moves to the social dimension. There are various ways, such as natural method, whole physical response methods, and suggested contemporary method, which are founded on the theory of the psycholinguist. These methods utilise psychological concepts, such as learning your first or second language (second language learning), learning a language (linguistic perception), and language (second language learning). The perception of languages refers to hearing and reading, while the creation of languages refers to speaking and writing. The four language skills are listening, reading, speaking, and writing. In particular, psycholinguistics helps comprehend the difficulty of intrinsic and extrinsic problems in these four skills. Psycholinguistics also contributes to explaining the language learning faults of students. In addition, psycholinguistics describes certain types of cerebral illnesses, such as graphics and aphasia, which must be treated appropriately, that influence language development. The use of the suitable approach for teaching these four linguistics teaches mainly psycholinguistic skills.
STRATEGI PENINGKATAN KEMAMPUAN BINTER KODAM JAYA BERBASIS TEKNOLOGI INFORMASI DALAM MENDUKUNG KESIAPAN OPERASIONAL
Authors: Panjaitan Frans Kishin , Yusuf Yusuf , Putra A I Nengah
Published: August 2022

Currently, Information Technology has developed very rapidly and affects all fields, including the implementation of the TNI's tasks, namely Binter. The Human Resources of Kodam Jaya requires the competency to utilize information technology. The condition of the competency Kodam Jaya of Binter and the competency to adapt for using information technology in the implementation of Binter is the object of this research with the formulation of the problems such as how is the competency of the Human Resources of Kodam Jaya in the field of information technology at this time, how are the obstacles faced in utilizing Information Technology in the implementation of Binter at Kodam Jaya and how Strategy to increase the capacity of Binter Kodam Jaya based on Information Technology to support operational readiness. The purpose of this study is to analyze the formulation of the problem using qualitative methods based on strategy theory, competency theory, information technology theory and territorial management theory to analyze the ability of territorial development in Kodam Jaya based on current information technology; the obstacles faced in utilizing information technology in the implementation of Binter at the Kodam Jaya; as well as a strategy to increase the capacity of Binter Kodam Jaya based on Information Technology to support operational readiness. The method used in this research is descriptive qualitative method with data collection techniques through interviews, indirect observation, document study and FGD. The results of the study show that the ability of Kodam Jaya territorial soldiers in mastering information technology is still limited by utilizing devices to support the implementation of Binter so that a strategy is needed to overcome the obstacles faced and requires leadership transformation in the form of giving orders to the members directly. Further research is recommended to examine the problems of increasing capacity in the field of information technology for the successful implementation of Binter in supporting operational readiness.Keywords: Binter, Competency, Information Technology, Strategy Readiness
THE EFFECT OF MILITARY DISCIPLINE AND MILITARY TRAINING TOWARD UNIT PERFORMANCE OF THE 13 TH ENGINEERING CONSTRUCTION BATTALION
Authors: Fadli Fauzan
Published: August 2022

Construction Engineer Battalion 13/Karya Etmaka abbreviated as Yonzikon 13/KE is required to have high unit performance. The success of carrying out the tasks given by the Indonesian Army is highly expected. However, the performance of this unit is predicted to be not optimal. This condition is influenced by various factors, including the implementation of military training is not optimal and there are still violations of military discipline among soldiers. The research problem is about the effect of military discipline and military training on the performance of the Yonzikon 13/KE unit. This research carried out to analyze the effect of military discipline and military training on unit performance partially and simultaneously. This research uses quantitative research methods with multiple linear regression techniques. Data were collected from 211 soldiers as a sample selected by the stratified random sampling method from a population of 445 soldiers. The results of the study show that: (1) military discipline has a positive and significant effect on unit performance, meaning that military discipline needs to be enforced at Yonzikon 13/KE if you want increased performance, (2) military training has a positive and significant effect on unit performance, the effect is more dominant. compared to military discipline, so that if you want to improve unit performance, increasing the quantity and quality of military exercises is important to carry out, and (3) military discipline and military training simultaneously have a positive and significant effect on unit performance, this means that military discipline and military training are variables. important variables in an effort to improve the performance of the Yonzikon 13/KE unit, so both need to be improved. The conclusion is that military discipline and military training have a positive and significant effect on the performance of the Yonzikon 13/KE unit, partially or simultaneously .Keywords: military discipline, military training, unit performance, yonzikon 13 ( battalion engineers construction 13), engineer
INDONESIA NATIONAL ARMY TO CONSTRUCT VILLAGE IN EMPOWERMENT OF DEFENSE AREA (CASE IN MILITARY DISTRICT COMMANDER (KODIM) 0814/JOMBANG 2018)
Authors: Romansah Dony
Published: August 2022

The TMMD policy is part of the TNI service operation carried out by the TNI together with the Regional Government and the community to help improve the welfare of the community and support the empowerment of defense territories. However, the implementation, the TMMD program that has been implemented has not been optimal because of problems in its implementation such as setting targets, lack of budget and manuals that have not been updated. The purpose of this research is to analyze the implementation of TMMD policies in the empowerment of defense areas in Kodim 0814/Jombang in 2018. This study uses qualitative methods. Data obtained from the specified informants were then analyzed using interactive analysis techniques. The results showed that the implementation of TMMD policies in Kodim 0814/Jombang in 2018 had not been implemented out optimally, both in terms of communication, resources and bureaucratic structure. This has an impact on the lack of results of the 101st TMMD implementation so that the empowerment of defense areas is not optimal. Efforts that can be carried out are by increasing the physical development budget of the Regional Government as well as adding food allowance and pocket money to the TMMD Task Force by TMMD Guidance, determining TMMD targets that must be bottom-up planning according to criteria, providing knowledge and skills for Kodim 0814/Jombang to work together with the Regional Government and the University, increasing the role of the Ministry of RI/LPNK by preparing rice for the people in the TMMD location and contact facilities can be sent before the implementation of TMMD .Keywords : Implementation, Policy, Be United, Empowerment and Defense.
52 INTEROPERABILITY OF COMMAND TROOPS WITH COMBAT AIRCRAFT AND HELICOPTER PERSONNEL IN SUPPORTING COMBAT S EARCH AND RESCUE OPERATIONS
Authors: Rusliana Raden Ruli , Dwiyanto Herly , Mansyah Agus
Published: August 2022

The interoperability of the Paskhas (Indonesian Airforce Special Troops) Combat SAR (CSAR) Team with elements of RESCAP and RESCORT combat aircraft and CSAR helicopters is very much needed in the implementation of Combat SAR Operations. However, exercises are rarely carried out with the dynamics of actual and complex Combat SAR operation scenarios, at this time the exercises are only limited to demonstrations of Combat SAR operations. The current problems are the lack of Ground Forward Air Control (GFAC) capability of the Combat SAR (CSAR) team, the lack of training with aircraft elements, special equipment and limited infrastructure, and the absence of software to support the creation of Interoperability of the Paskhas Combat SAR (CSAR) Team with elements of fighter aircraft and helicopters. The purpose of this study was to analyze the existing and ideal conditions of interoperability of the Combat SAR Paskhas team with the crew of RESCAP, RESCORT and CSAR helicopters to support Combat SAR operations and the efforts made to overcome these interoperability constraints. The method used is qualitative. The results of the discussion of this study are that the interoperability of the Paskhas Combat SAR (CSAR) Team with elements of RESCAP fighter aircraft, RESCORT fighter elements, and CSAR helicopter elements is not optimally.Keywords: Interoperability, Capability, Paskhas (Indonesian Airforce Special Troops), Combat SAR Operations
SINERGI PANGKALAN TENTARA NASIONAL INDONESIA ANGKATAN UDARA DAN BANDARA HALIM PERDANAKUSUMA MENGANTISIPASI ANCAMAN MILITER
Authors: Wijaya Roni
Published: August 2022

The existence of the air base often intersects with the airport. This condition needs to be understood because it is known that the Indonesian Air Force base is not only used for defense but also for civil or commercial aviation, namely the Civil Inclave Airport as happened at Halim Perdanakusuma. The existence of the Halim Perdanakusuma Air Force Base and Halim Perdanakusuma Airport which are in one room is certainly not an easy matter, moreover it only has one runway that is used together where each has its own orientation, as it is known that the Air Base has a concern for building defense bases while The airport is oriented towards commercial flights. Conditions are getting more difficult with increasingly complex dynamics of threats so that constructive efforts are needed in the form of anticipating military threats and aviation safety. The research method used is a qualitative method with a phenomenological research design. The data obtained from the specified informants were then analyzed using qualitative techniques. From this study it was concluded that 1) the implementation of base defense at Halim Perdanakusuma AFB in anticipating military threats had not been carried out optimally, 2) the implementation of flight operations at Halim Perdanakusuma Airport in anticipating flight safety referring to existing provisions, and 3) synergy between Halim Perdanakusuma AFB and Halim Perdanakusuma Airport in anticipating military threats and aviation safety have not been implemented properly.Keywords: synergy, base defense, flight operations, military threats, aviation safety
MARINE DEFENSE STRATEGY WITH MILITARY BASE DEVELOPMENT ON THE OUTSIDE ISLAND AS A LEADING DEFENSE AND DEFENSE MOBILITY
Authors: Naibaho De Yoshinov SM
Published: August 2022

The construction of military bases on small islands is useful for providing mobility access to patrol boats to obtain fuel supplies or logistics. Can also provide assistance in the pursuit of foreign ships that enter Indonesian seas without permission, where the base already has a fleet ready with fast warships. The Military Base will greatly assist the mobility of the Navy in maintaining the Sovereignty of the Unitary State of the Republic of Indonesia. Evidence of the lack of Indonesian Marine Defense has made countries bordering Indonesia to make their own claims to maritime boundaries, especially in the North Natuna Sea. Two Vietnamese government surveillance vessels reportedly hit the hull of the Indonesian Navy ship KRI Tjiptadi-381 in the North Natuna Sea. Apart from claims and theft of natural resources in the Indonesian seas, currently there is also a heated issue between China and Australia, due to the US-UK-Australia cooperation called AUKUS. The Base Duties said that Lantamal's main tasks were to provide combat support, logistical support, administrative support and special support for elements of the Navy (Ships, Pesud and Marines), carry out operations and empower facilities and infrastructure owned by the base itself and related agencies. in its territory. This support capability is commonly known as the '5R' function, namely Rebase, Replenishment, Repair, Rest and Recreation. Base development on the outer islands is a form of defense and proof to countries bordering Indonesia, that the Republic of Indonesia has the power to deal with forces power that wants to threaten or claim the sovereignty of the Unitary State of the Republic of Indonesia. The construction of the base is one that supports the development of defense, the construction of bases on small islands located in the outermost parts can be used as military bases that are useful as front-line defense and also access to defense mobility, as well as carrying out the main tasks and functions of the base.
SOCIAL COMMUNICATION STRATEGY THROUGH SPILL MARKET ACTIVITIES TO ACHIEVE NATIONAL SECURITY IN CIMAHI CITY
Authors: Cahyono Afiid
Published: August 2022

National security is the basic need of every citizen besides welfare. Oneof the ways to achieve national security is to increase the deterrence power of the community in dealing with every problem in their environment. Therefore, 15th/Kujang II Infantry Brigade strives to embody those purposes with social communication strategy through spilled market activity. Social communication development is one of several methods of Territorial Management of the Indonesian Armed Forces in the form of communication activity that is carried out effectively and sustainably. This social communication strategy is applied as a medium for socialization, as a medium for equalization of vision, mission and interpretation of media for coordination, integration, synchronization and simplication as well as a means to improve, maintain and strengthen the unity of the Indonesia Armed Forces and society in order to achieve main tasks of Indonesia Armed Forces. Yet in implementing territorial management through that social communication development, this endeavor is still not in accordance with the expected goals. Therefore, in order this spilled market activity does not seem like a common market in general, this study was conducted to analyze the social communication strategy of the 15 th /Kujang II Infrantry Brigade also the constraints in its progress through spilled market activity to embody national security in Cimahi City.In order to achieve that purpose, this research is conducted with qualitative method, depth-interview technique, passive observation and document review. This research found that social communication strategy that was conducted by 15 th /Kujang II Infantry Brigade is by educating society about social problems that occur in the society and their role in problem solving in the community. 15 th /Kujang II Infrantry Brigade also conducting territorial guidanve to the whole community that the community also plays a role in realizing national security through awareness, as it is their role as an early detection and early prevention in a society, as a form of deterrence for threats. While the constraints encountered in fostering social communication are mechanicaldisturbances, factors of interest, motivation and prejudice by the public of what isintended by 15 th /Kujang II Infantry Brigade.Keywords : National Security, Territorial Management, Social Communication, Strategy, Indonesia Armed Forces
High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes
Authors: Teichman Jennifer , Geddes Michelle , Zhu Nancy , Keating Mary-Margaret , Sabloff Mitchell , Christou Grace , Leber Brian , Khalaf Dina , St-Hilaire Eve , Finn Nicholas , Shamy April , Yee Karen W.L. , Storring John M. , Nevill Thomas J. , Delage Robert , Elemary Mohamed , Banerji Versha , Houston Brett , Mozessohn Lee , Chodirker Lisa , Zhang Liying , Siddiqui Mohammed , Parmentier Anne , Leitch Heather A. , Buckstein Rena J.
Published: August 2022

Iron overload (IO) reflected by elevated ferritin is associated with increased mortality in myelodysplastic syndromes (MDS), however, ferritin is an imperfect metric. Elevated labile plasma iron correlates with clinical outcomes and transferrin saturation (TSAT) >80%, but is not readily measurable. The trajectory of TSAT, and its association with clinical outcomes remain undefined. Canadian MDS registry patients were evaluated. Mean TSAT, mean ferritin and transfusion dose density (TDD) were determined. Survival was evaluated by TSAT and ferritin (<50%, 50-80%, >80%), (≤500 μg/L, 501-800 μg/L, >800 μg/L). In 718 patients, median age was 74 years; 12%, 31%, 29%, 15% and 13% were IPSS-R very low, low, intermediate, high and very high. TSAT and ferritin were moderately correlated (r=0.63, P<0.0001). TSAT increased over time in transfusion- dependent patients (P=0.006). Higher TSAT and ferritin were associated with inferior 5-year overall (OS), progression- free (PFS), and leukemia-free survival (LFS) (P≤0.008) and higher TDD with inferior 5-year OS. TSAT >80% trended with inferior cardiac death-free survival (P=0.053). In univariate analysis, age, IPSS-R, blast percentage by Eastern Cooperative Oncology Group Performance Status, frailty, Charlson Comorbidity Index, iron chelation (Y/N), TDD, TSAT and ferritin were significantly associated with inferior OS. By multivariable analysis, TSAT >80% (P=0.007) remained significant for OS (R2 30.3%). In MDS, TSAT >80% and ferritin >800 μg/L portended inferior OS, PFS and LFS. TSAT may indicate the presence of oxidative stress, and is readily measurable in a clinical setting. The relationship between TSAT and cardiac death-free survival warrants further study.
La necesidad de configuración legal del canibalismo como delito en el COIP
Authors: Silva Flores Lady Escarleth , Sánchez Oviedo Danny Xavier
Published: August 2022

La presente investigación plantea como objetivo indagar si es que es necesaria la tipificación del canibalismo como delito en la legislación penal ecuatoriana. Es una competencia del Estado garantizar la inviolabilidad de la vida y los derechos humanos, en la actualidad pueden suscitarse actos que atentan contra la dignidad, la integridad, la salud y la vida del ser humano. Uno de estos casos es el canibalismo, para entender este acto se procedió a investigar qué es y cómo afectan estos actos a la sociedad. Así como también una breve investigación de los casos de canibalismo que se han dado en otros países y el vacío legal que existe en el Código Orgánico Integral Penal para juzgar estas conductas antisociales. Para estructurar esta investigación se han sustentado algunos casos de canibalismo en donde solo se ha podido jugar el homicidio y no se ha establecido artículos dentro del código que juzguen actos caníbales, dejando abierta la posibilidad de realizar estos actos sin ser juzgado como un delito y además imposibilitando la oportuna recolección de datos que permitan tomar decisiones sobre la política criminal. Una vez argumentado lo que es el canibalismo, los actos que se han cometido bajo este precepto de canibalismo y se pueda identificar claramente el bien jurídico afectado por estos actos, se plantea una propuesta de tipificación de esta figura dentro de la legislación penal. En donde se establezcan sanciones para los distintos actos de canibalismo que cometen las personas tomando en cuenta la forma y las circunstancias en que las cometen y sean juzgadas en base a la gravedad de sus actos. Se concluye que una reforma en el Código Orgánico Integral Penal ayuda a eliminar vacíos legales, permitiendo la aplicación de sanciones ante actos que perjudiquen el derecho de la sociedad a vivir en armonía.
Mínima intervención penal en los delitos de bagatela en el cantón Cuenca-Ecuador
Authors: Naranjo Vintimilla Juan Pablo , Vázquez Calle José Luis
Published: August 2022

El presente estudio se realizó con la finalidad de analizar críticamente la aplicabilidad del principio de mínima intervención penal en los delitos de bagatela por parte de los operadores de justicia y su incidencia en la carga procesal de las unidades penales del cantón Cuenca. Para ello desde un enfoque cualitativo, se planteó una revisión bibliográfica complementada datos sobre la judicialización de delitos de bagatela y la carga procesal. Se justificó teóricamente la necesidad de masificación de procesos alternativos de solución de conflictos en los delitos de bagatela en aplicación del principio de mínima intervención penal.
Transmission of Radiation-Induced Genome Instability from Irradiated Parents to their Offspring
Authors:   Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia, Oslina D.S. , Rybkina V.L. ,   Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia, Azizova T.V. ,   Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk region, Russia
Published: August 2022

Numerous studies allow to suppose a transmission of radiation-induced genome instability from irradiated parents to their offspring on cell, chromosome and molecular genetic level. This review focuses on transmission of radiation-induced genome instability from irradiated parents to their offspring. Data of genome instability in animal experiments and in offspring of occupationally exposed human or human exposed in a radiation accident, and in offspring of parents exposed to radiotherapy are reviewed. The possible mechanisms of lineage transmission of genome instability are discussed. High dose irradiation can lead to DNA damage, changes in methylation patterns and miRNAs expression in parents and their offspring and result in mutations, chromosome aberration and destabilization of genome. Non-coding RNAs (miRNA, piRNA, nsRNA) are supposed to contribute to transgenerational effects, since they can target genes, change chromatin structure and disregulate gene expression.
Igor Borisovich Keirim-Markus (on the Occasion of His 100th Birthday)
Authors:   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Efimova I.L.
Published: August 2022

The article contains material on the scientific activity and life path of a well-known scientist in the field of radiation safety, the first head of the laboratory of emergency and individual dosimetry, one of the developers of the first neutron dosimeter in the USSR. This publication is a historical review of materials from the collection of the Museum of the FMBTS. A.I.Burnazyan, the archive of the scientist’s family, printed publications, is of scientific interest because it holistically presents the life and scientific path of the famous scientist who gave 58 years of service to science within the walls of the Institute of Biophysics (now part of the A.I.Burnazyan FMBC) . The scientist made a great contribution to the formation of a new area of ​​science at the intersection of dosimetry, radiobiology and radiation medicine, named equidosimetry at his suggestion. The museum keeps the book of I.B.Keirim-Markus "Equidosimetry", where for the first time in the world scientific literature summarized materials on the main sections of equidosimetry, the history of its occurrence, tasks, criteria for assessing the effect of radiation, in particular in large doses, the values ​​of equidosimetry, methods and instruments for their measurement.
Hygienic Aspects of Special Assessment of Working Conditions with Ionizing Radiation Sources
Authors:   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Proskuryakova N.L. , Simakov A.V. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Abramov Yu.V. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia.
Published: August 2022

Purpose: Substantiation of hygienic approaches to assessing the working conditions of personnel when working with sources of ionizing radiation. Material and methods: The article considers one of the most important components of the complex of measures to solve the problem of ensuring radiation safety – conducting a special assessment of the working conditions (SAWC) of workers exposed to radiation from ionizing radiation sources (IRS) in the course of production activities. The issues of assessing occupational risks for workers in working conditions when working with IRS at nuclear energy use facilities are touched upon. Results: At present, the Procedure for conducting the SAWC is determined by Federal Law No. 426-FZ dated December 28, 2013 «On special assessment of working Conditions» and the Methodology for conducting a special assessment of working conditions (approved by the order of the Ministry of Labor of the Russian Federation dated November 14, 2016, No. 642n). The established procedure for carrying out the SAWC is based on the hygienic criteria for the classification of working conditions defined by the Guidelines P 2.2.2006-05 and P 2.6.5.07–2019. Working conditions when working with ionizing radiation sources, unlike the effects of other harmful production factors, are characterized by the presence of harmful production factors that do not exceed hygienic standards, and the degree of harmfulness of working conditions is determined not so much by the severity of threshold deterministic effects in workers when irradiating individual organs, but primarily by an increase in the risk of stochastic non-threshold effects. Conclusion: When conducting the SAWC of workers exposed to radiation from ionizing radiation sources in the course of production activities, it is necessary to take into account the following distinctive characteristics of the effects of ionizing radiation: – in contrast to the principles of classification of working conditions set out in P 2.2.755-99 and Federal Law No. 426-FZ, when working with IRS, harmful working conditions are characterized by the presence of production factors that do not exceed hygienic standards; – when working with ionizing radiation sources, the degree of harmfulness of working conditions is determined not only by the severity of the manifestation of threshold deterministic effects in workers, but mainly by an increase in the risk of stochastic threshold-free effects; – the correct conduct of the SAWC and assessment of working conditions according to the indicators of harmfulness and danger when working with IRS are a prerequisite for the quantitative assessment of the occupational risk of employees of the nuclear energy use facilities.
Incidence and Mortality from Central Nervous System Tumors in the Cohort of Workers Chronically Exposed to Radiation
Authors:   Southern Urals Biophysics Institute of the Federal Medical Biological Agency, Ozyorsk, Russia., Moseeva M.B. , Azizova T.V. ,   Southern Urals Biophysics Institute of the Federal Medical Biological Agency, Ozyorsk, Russia., Bannikova M.V. ,   Southern Urals Biophysics Institute of the Federal Medical Biological Agency, Ozyorsk, Russia.
Published: August 2022

Purpose: To analyze incidence and mortality rates of central nervous system (CNS) primary tumors (PT) in the cohort of workers chronically exposed to radiation. Material and methods: Study cohort included 22237 Mayak Production Association workers. Work history data and dose estimates from the “Mayak Worker Dosimetry System 2013” were used. Clinical and epidemiology data were obtained from the “Clinic” database. Crude and age-adjusted (by indirect method) incidence and mortality rates for CNS PT per 100000 person-years were calculated. Standardized incidence and mortality trends were analyzed by Jointpoint 4.0.4. Results: 53 cases and 47 deaths from malignant neoplasms (MN) of brain and spinal cord, cerebral nerve and other parts of CNS (C70–C72 ICD-10 codes) as well as 40 cases and 7 deaths from non-malignant neoplasms (NMN) of brain and other parts of CNS (D-33 ICD-10 code) were identified. CNS MN were more frequent among males (83 %), and CNS NMN were more frequent among females (55 %). Both CNS MN and NMN developed at younger ages among males as compared with females, CNS PT frequency increased with increased attained age. Analysis in relation to calendar period revealed the increasing trend for CNS PT incidence among females only (р=0,008). Effects of chronic occupational radiation exposure on CNS PT incidence and mortality rates were not established either among males or females. Conclusion: Findings should be considered as preliminary and require further studies.
X-ray Estimation of Structural-topographic Parameters of the Tempo-low Jaund Joint After Orthognic Surgical Treatment of Dental Jaws with Condition
Authors:   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Mokhirev M.A. , Kaganova O.S. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Olesova V.N. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Ermolin V.I. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Olesov E.E. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia., Ilyin A.A. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia.
Published: August 2022

Purpose: Using the methods of radiation diagnostics, to trace in dynamics the structural and topographic state of the temporomandibular joint (TMJ) before and after orthognathic treatment of patients with air conditioning Material and Methods: A CT analysis of the TMJ condition was carried out before and after orthodontic surgical removal of the dentofacial anomaly (skeletal form) with the effects of Candyline resorption. We used the method of Fadeev R.A. et al. to assess the TMJ parameters: height of the head of the lower jaw; anterior and posterior articular angle; the width of the joint space in the upper, anterior, posterior, mesial and lateral sections; maximum width of the head of the lower jaw; density of cortical and cancellous bones of the head of the lower jaw; height of the articular fossa; the length of the anterior slope of the articular fossa; angle of the anterior slope of the articular fossa; the length of the posterior slope of the articular fossa; angle of the posterior slope of the articular fossa. Results: Comparison of CT parameters of TMJ before and after orthognathic treatment reveals a positive trend in remodeling of the articular process of the lower jaw after surgery, as evidenced by a noticeable increase in the width of the head of the lower jaw with a slight decrease in its height. The absence of compression in the bilaminar zone of the TMJ is recorded due to an increase in the width of the joint space in the posterior section, although the width of the joint space in the upper and anterior sections still does not correspond to normal values. The preservation of a lower density of the cortical and spongy layers of the articular head in comparison with the norm is apparently associated with continued adaptation to the new position of the articular processes and changed functional loads. Conclusion: A comprehensive orthodontic and surgical approach to the elimination of dentoalveolar anomalies is effective and can be recommended in the treatment of patients with skeletal anomalies and condyloresorption, as it provides not only a significant improvement in facial aesthetic parameters, but also has a positive effect on the structural and topographic parameters of the temporomandibular joint.
X-ray and Radionuclide Imaging in the Diagnosis of ACTH-Producing Neuroendocrine Tumors
Authors:   I.M. Sechenov First Moscow State Medical University, Moscow, Russia, Golounina O.O. , Slashchuk K.Yu. ,   The National Medical Research Center for Endocrinology, Moscow, Russia, Khairieva A.V. ,   The National Medical Research Center for Endocrinology, Moscow, Russia, Tarbaeva N.V. ,   The National Medical Research Center for Endocrinology, Moscow, Russia, Degtyarev M.V. ,   The National Medical Research Center for Endocrinology, Moscow, Russia, Belaya Zh.E. ,   The National Medical Research Center for Endocrinology, Moscow, Russia
Published: August 2022

Ectopic ACTH syndrome caused by excessive production of adrenocorticotropic hormone (ACTH) by a neuroendocrine tumor (NET) is an extremely rare disease, the main manifestation of which is pronounced hypercortisolism. In order to avoid the development of life-threatening complications and disability of the patient, timely topical diagnosis and rapid decision-making on further management tactics are necessary. The problem of the diagnosis of NET and differential diagnosis with other formations remains relevant and one of the little-studied. Despite the existing wide arsenal of methods of conventional diagnostics, functional and receptor imaging, the source of the disease remains unidentified in about 20% of patients. This article discusses the modern possibilities of NET visualization using conventional and radionuclide imaging methods, demonstrates the diagnostic capabilities of somatostatin-receptor scintigraphy and single-photon emission computed tomography combined with computed tomography (SPECT/CT) and combined positron emission and computed tomography (PET/CT) in the visualization of NET producing ACTH, and analyzes existing radiopharmaceuticals.
Anti-Glomerular Basement Membrane Antibody Disease with Mild Kidney Failure and Without Progression of Lung Pathology: Case Report
Authors:   Russian Medical Academy of Continued Professional Education, Moscow, Russia, Sheikh Zh.V. ,   S.P. Botkin’s City Clinical Hospital, Moscow, Russia., Nikolaev E.V. ,   Russian Medical Academy of Continued Professional Education, Moscow, Russia., Gazaryan Ya.R. ,   Russian Medical Academy of Continued Professional Education, Moscow, Russia., Safonova T.D. ,   Russian Medical Academy of Continued Professional Education, Moscow, Russia., Zakharova E.V. ,   Russian Medical Academy of Continued Professional Education, Moscow, Russia.,   S.P. Botkin’s City Clinical Hospital, Moscow, Russia.
Published: August 2022

Anti-GBM antibody disease (Goodpasture syndromee) is a rare immunecomlpex vasculitis, affecting small vessels, and characterized by rapidly progressive glomerulonephritis and alveolitis. Causative mechanism is defined by the hyperproduction of autoantibodies against the α3-chain of type IV collagen (Goodpasture antigen) with immune complex formation on the glomerular and alveolar basement membrane. Typically patients with fnti-GBM antibody disease present with rapidly progressive (crescentic) glomerulonephritis, more than in half of cases associated with alveolar hemorrhage. Cases of Anti-GBM antibody disease with atypical clinical presentation have been reported. We report a case of atypical clinical presentation anti-GBM antibody disease with mild renal damage and slow progression of pulmonary involvement. Main CT signs were multiple centrilobular ground glass nodules. This case report demonstrates that CT with disseminated pulmonary process associated with even mild kidney involvement in patients with high anti-GBM antibodies titers gives a clue to the diagnosis of anti-GBM antibody disease.
Outbreak of SARS-CoV-2 Delta variant on a single liquified natural gas (LNG) vessel, with estimates of vaccine effectiveness
Authors: Smoll Nicolas , Walker Jacina , Hassan Al Imam Mahmudul , Auriac Jill , Andrews Ross , Jeremijenko Andrew , Kirk Michael , Khandaker Gulam
Published: August 2022

In August 2021, there was an outbreak of severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) Delta variant on an international liquified natural gas (LNG) vessel offshore to Gladstone, Queensland. Fourteen of the 26 crew members aboard the vessel tested positive for SARS-COV-2 on PCR during the outbreak. Vaccine effectiveness (VE) was 52% for all lab-confirmed SARS-CoV-2 infections, 65% for symptomatic SARS-CoV-2 infection and 100% for severe SARS-CoV-2. The attack rate (AR) of SARS-CoV-2 Delta variant was 54% (14/26). With heightened public health measures and infection control practices, we were able to declare the outbreak over in 26 days.
Australian National Enterovirus Reference Laboratory annual report, 2021
Authors: Kaye Matthew B , Garcia-Clapes Arnau , Hobday Linda K , Ibrahim Aishah , Chanthalavanh Presa
Published: August 2022

Australia monitors its polio-free status by conducting surveillance for cases of acute flaccid paralysis (AFP) in children less than 15 years of age, as recommended by the World Health Organization (WHO). Cases of AFP in children are notified to the Australian Paediatric Surveillance Unit or the Paediatric Active Enhanced Disease Surveillance System, and faecal specimens are referred for virological investigation to the National Enterovirus Reference Laboratory. In 2021, no cases of poliomyelitis were reported from clinical surveillance and Australia reported 1.31 non-polio AFP cases per 100,000 children, thereby meeting the WHO’s performance criterion for a sensitive surveillance system. The non-polio enteroviruses coxsackievirus A4, coxsackievirus A10, coxsackievirus A13 and enterovirus A71 were identified from clinical specimens collected from AFP cases. Australia also performs enterovirus and environmental surveillance to complement the clinical system focussed on children. In 2021, there were five cases of wild poliovirus reported from the two remaining endemic countries: Afghanistan and Pakistan. Including Afghanistan and Pakistan, 22 countries also reported cases of AFP due to circulating vaccine-derived poliovirus.
Gestión logística y atención al cliente en una empresa industrial del rubro alimentos, Lima 2021
Authors: Zelada Flórez Edwin Andersson
Published: August 2022

La presente investigación tuvo como objetivo determinar la relación que existe entre la gestión logística y la atención al cliente en una empresa industrial del rubro alimentos en Lima 2021. Amparado en un método de investigación cuyo método fue hipotético-deductivo, con una tipología aplicada, con nivel investigativo descriptivo y correlacional, bajo el diseño no experimental, de corte transversal y enfoque cuantitativo. La población estuvo circunscrita a 400 colaboradores de la empresa en cuestión y la muestra fue calculada con la fórmula de población finita, arrojando la cifra de 197 personas. La técnica de recolección de datos fue la encuesta y el instrumento un cuestionario de elaboración propia, el mismo que fue sometido a confiabilidad de Alpha de Cronbach. Posterior a la indagación en campo, fueron procesados los datos con el software SPSS considerando la evaluación por cada interrogante y luego por baremos establecidos, cabe precisar que luego de analizar la normalidad de la data y con lo resultante, se procedió a utilizar el estadígrafo de Rho de Spearman cuyos resultados inferenciales demostraron una relación entre las dos variables. Llegándose a la conclusión de que sí existe relación entre la gestión logística y la atención al cliente, al igual que existe relación con cada una de las dimensiones de la gestión logística (gestión de materiales y distribución física) respecto a la variable dependiente.
The Pattern, Flow, Tempo of the Importance of Circadian Rhythm of Pain, And Analgesic Treatments
Authors: Smith Robert G
Published: August 2022

The lower extremity specialist may have come to appreciate and respect that medical treatments that can be enhanced by an understanding of pharmacodynamics, pharmacogenomics, and pharmacokinetics of selected medications to include analgesics specifically opioids. Furthermore, these same foot and ankle specialist may fine- tune their prescribing abilities with analgesics by familiarizing himself or herself with the science of chronotherapy. The primary goal of chronotherapy is to determine times for drug delivery that allows for low toxicity and an increase in a medication’s efficacy. Chrono pharmaceutics has been described as a branch of pharmaceutics devoted to the design of drug delivery system to ensure that a bioactive agent’s release at a rhythm ideally matches the biological requirement of a given disease. The primary purpose of this narrative review is to describe, explore and present Chrono therapeutic concepts as they intersect with analgesics within the context of pain management and circadian rhythms. First, data and theories on the interaction of pain pathology and circadian rhythm will be introduced. Secondly, the science of pharmacogenomics and circadian rhythms as mediators of analgesic properties, specifically opioid drug-drug interactions grounded in the effects of pharmacokinetic metabolism will be presented. Lastly, relevant technology will be described to allow a lower extremity specialist to appreciate Chrono therapeutic drug delivery systems of a specific opioid analgesic.