bluuebunny/crossref_metadata_2025 huggingface dataset:
Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations
Authors: Augestad Knut Magne , Merok Marianne A , Ignatovic Dejan
Published: March 2017

Colorectal cancer (CRC) is a complex cancer disease, and approximately 40% of the surgically cured patients will experience cancer recurrence within 5 years. During recent years, research has shown that CRC treatment should be tailored to the individual patient due to the wide variety of risk factors, genetic factors, and surgical complexity. In this review, we provide an overview of the considerations that are needed to provide an individualized, patient-tailored treatment. We emphasize the need to assess the predictors of CRC, and we summarize the latest research on CRC genetics and immunotherapy. Finally, we provide a summary of the significant variations in the colon and rectal anatomy that is important to consider in an individualized surgical approach. For the individual patient with CRC, a tailored treatment approach is needed in the preoperative, operative, and postoperative phase.
Crosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity
Authors: Kemp Michael G
Published: March 2017

Autoimmune disorders constitute a major and growing health concern. However, the genetic and environmental factors that contribute to or exacerbate disease symptoms remain unclear. Type I interferons (IFNs) are known to break immune tolerance and be elevated in the serum of patients with autoimmune diseases such as lupus. Extensive work over the past decade has characterized the role of a protein termed stimulator of interferon genes, or STING, in mediating IFN expression and activation in response to cytosolic DNA and cyclic dinucleotides. Interestingly, this STING-dependent innate immune pathway both utilizes and is targeted by the cell’s autophagic machinery. Given that aberrant interplay between the apoptotic and autophagic machineries contributes to deregulation of the STING-dependent pathway, IFN-regulated autoimmune phenotypes may be influenced by the combined exposure to environmental carcinogens and pathogenic microorganisms and viruses. This review therefore summarizes recent data regarding these important issues in the field of autoimmunity.
Prognostic factors versus markers of response to treatment versus surrogate endpoints: Three different concepts
Authors: Sormani Maria Pia
Published: March 2017

Multiple sclerosis is a highly heterogeneous disease; the quantitative assessment of disease progression is problematic for many reasons, including the lack of objective methods to measure disability and the long follow-up times needed to detect relevant and stable changes. For these reasons, the importance of prognostic markers, markers of response to treatments and of surrogate endpoints, is crucial in multiple sclerosis research. Aim of this report is to clarify some basic definitions and methodological issues about baseline factors to be considered prognostic markers or markers of response to treatment; to define the dynamic role that variables must have to be considered surrogate markers in relation to specific treatments.
The partner’s perspective of the impact of pituitary disease: Looking beyond the patient
Authors: Andela Cornelie D , Tiemensma Jitske , Kaptein Adrian A , Scharloo Margreet , Pereira Alberto M , Kamminga Noëlle GA , Biermasz Nienke R
Published: March 2017

People with pituitary disease report impairments in quality of life. The aim of this study was to elucidate the impact of the pituitary condition on the lives of partners. Four focus groups of partners of people with pituitary disease (Cushing’s disease, non-functioning adenoma, acromegaly, prolactinoma) were conducted. Partners mentioned worries related to the pituitary disease and negative beliefs about medication, coping challenges, relationship issues, social issues and unmet needs regarding care. This study emphasizes the importance of not only paying attention to psychosocial well-being of people with pituitary disease but also to their partners.
‘My Father’s Name’: A Survey of Research on the Use of onoma with Respect to the Father in the Fourth Gospel
Authors: Coutts Joshua
Published: March 2017

This essay provides a survey of research for one distinctive feature of the Fourth Gospel, namely, the striking emphasis on ‘name’ ( onoma) language used with reference to the Father. The small existing body of research on John’s divine name concept may be situated in the context of a resurgent interest in the question of ‘God’ in the Fourth Gospel, and alongside broader New Testament research focused on the application of ‘ kyrios’ to Jesus or on the divine functions attributed to Jesus’ own name. The research that has focused on John’s use of the divine name may be divided into two groups: there are attempts to identify the background to John’s name concept, including proposals for a Jewish hypostatic name concept, targumic tradition or the text of Isaiah; and studies which analyse John’s name language have sought to locate its meaning within the context of the Gospel itself.
African Biblical Studies: An Introduction to an Emerging Discipline
Authors: Mbuvi Andrew M.
Published: March 2017

African Biblical Studies (ABS) can be characterized both as innovative and reactionary: Innovative, because it refuses to be confined by the methodologies, ancient concerns, and principles that govern biblical studies in the ‘west’ (used throughout this article to refer to the majority Euro-American scholars while recognizing the presence of other groups), and instead charts a course that is more interested in making biblical interpretation relevant to present realities. Reactionary, because its driving force is partly a critique of the inadequacy of western biblical studies in providing meaningful responses to concerns that are pertinent to African communities. A genuine ABS is therefore an amalgamation of multiple interpretive methods, approaches and foci that reflect a creative engagement of the African cosmological reality and the Bible.
Personalized Individual and Group Therapy for Multifaceted Selective Mutism
Authors: Skedgell Kyleigh K. , Fornander Mirae , Kearney Christopher A.
Published: March 2017

Selective mutism refers to a persistent and debilitating condition in which a child fails or refuses to speak in public situations. Research on treatment for selective mutism has progressed in recent years toward a more personalized model based on clinical profiles unique to a given child. Such profiles may include aspects of anxiety, oppositional behaviors, and communication problems as well as operant factors that maintain selective mutism. The present case represents a 6-year-old child with selective mutism with a multifaceted clinical profile that included internalizing and externalizing behavior problems with multiple operant factors. Initial personalized individual therapy focused on anxiety and contingency management procedures to address school refusal behavior and to lay the groundwork for later treatment of selective mutism. Group therapy with parent and child components focused on these procedures in more detail in addition to social skills development. Each component included detailed hierarchies for increasing frequency and audibility of speech in a clinic setting as well as in community and school settings.
Association of statins with aortic, peripheral, and visceral artery aneurysm development
Authors: Mansi Ishak A , Frei Christopher R , Halm Ethan A , Mortensen Eric M
Published: March 2017

Objectives

Prior studies examining the effects of statins on arterial aneurysm development and progression yielded conflicting results due to their smaller size and presence of residual confounders. The objective of this study is to examine the association of statins with risk of being diagnosed with aortic, peripheral, and visceral artery aneurysm.

Methods

This was a retrospective cohort study of Tricare enrollees (from 1 October 2003 to 31 March 2012). Main outcomes were diagnosis of aortic, peripheral, or visceral artery aneurysm and undergoing aortic aneurysm repair procedure during follow-up period. Using 115 baseline characteristics, we generated a propensity score to match statin users and nonusers and examine the odds of outcomes (primary analysis). Secondary analysis examined outcomes at various subcohorts.

Results

Out of 10,910 statin users and 49,545 nonusers, we propensity score-matched 6728 pairs of statin users and nonusers. Statin users and nonusers had similar odds of being diagnosed with aortic, peripheral, and visceral artery aneurysms (odds ratio [OR]: 1.06, 95% confidence interval [95% CI]: 0.85–1.33) and of undergoing aortic aneurysm repair procedures (OR: 0.54, 95% CI: 0.22–1.35). Secondary analysis showed a tendency toward fewer aortic aneurysm procedures among statin users that did not reach statistical significance. However, high-intensity statin users in comparison to non-intensive statin users had higher adjusted odds of aortic, peripheral, and visceral artery aneurysms (OR: 1.76, 95% CI: 1.37–2.25, p < .0001).

Conclusions

This study does not support a clinically significant benefit or harm from statins regarding development of arterial aneurysm. However, secondary analyses may support the hypothesis proposed by previous research proposing a bidirectional role for statins.
Macrolides: a promising pharmacologic therapy for chronic obstructive pulmonary disease
Authors: Qiu Shilin , Zhong Xiaoning
Published: March 2017

Chronic inflammation plays a central role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, there are no effective anti-inflammatory pharmacologic therapies available for COPD so far. Recent evidence suggests that an immunologic mechanism has a role in the pathogenesis of COPD. Macrolides possess anti-inflammatory and immune-modulating effects may be helpful in the treatment of COPD. Several clinical studies have shown that long-term use of macrolides reduces the frequency of COPD exacerbations. However, the subgroups that most effectively respond to long-term treatment of macrolides still need to be determined. The potential adverse events to individuals and the microbial resistance in community populations raises great concern on the long-term use of macrolides. Thus, novel macrolides have anti-inflammatory and immuno-modulating effects, but without antibiotic effects, and are promising as an anti-inflammatory agent for the treatment of COPD. In addition, the combination of macrolides and other anti-inflammatory pharmacologic agents may be a new strategy for the treatment of COPD.
The link between infant regulatory problems, temperament traits, maternal depressive symptoms and children’s psychopathological symptoms at age three: a longitudinal study in a German at-risk sample
Authors: Sidor Anna , Fischer Cristina , Cierpka Manfred
Published: March 2017

Background

Difficult conditions during childhood can limit an individual’s development in many ways. Factors such as being raised in an at-risk family, child temperamental traits or maternal traits can potentially influence a child’s later behaviour. The present study investigated the extent of regulatory problems in 6-month-old infants and their link to temperamental traits and impact on externalizing and internalizing problems at 36 months. Moderating effects of maternal distress and maternal depressive symptoms were tested as well.

Methods

In a quasi-experimental, longitudinal study, a sample of 185 mother-infant dyads at psychosocial risk was investigated at 6 months with SFS (infants’ regulatory problems) and at 3 years with CBCL (children’s behavioural problems), EAS (children’s temperament), ADS (maternal depressive symptoms) and PSI-SF (maternal stress).

Results

A hierarchical regression analysis yielded a significant association between infants’ regulatory problems and both externalizing and internalizing behaviour problems at age 3 (accounting for 16% and 14% variance), with both externalizing and internalizing problems being linked to current maternal depressive symptoms (12 and 9% of the variance). Externalizing and internalizing problems were found to be related also to children’s temperamental difficulty (18 and 13% of variance) and their negative emotionality. With temperamental traits having been taken into account, only feeding problems at 6 months contributed near-significant to internalizing problems at 3 years.

Conclusions

Our results underscore the crucial role of temperament in the path between early regulatory problems and subsequent behavioural difficulties. Children’s unfavourable temperamental predispositions such as negative emotionality and generally “difficult temperament” contributed substantially to both externalizing and internalizing behavioural problems in the high-risk sample. The decreased predictive power of regulatory problems following the inclusion of temperamental variables indicates a mediation effect of temperamental traits in the path between early regulatory problems and subsequent behavioural problems. Our results support the main effects of a child’s temperament, and to some degree maternal depressive symptoms, rather than the diathesis stress model of interaction between risky environment and temperamental traits.

Trial registrationD10025651 (NZFH)
Open Online Courses in Public Health: experience from Peoples-uni
Authors: Heller Richard F. , Zurynski Robert , Barrett Alan , Oaiya Omo , Madhok Rajan
Published: March 2017

Open Online Courses (OOCs) are offered by Peoples-uni at http://ooc.peoples-uni.org to complement the courses run on a separate site for academic credit at http://courses.peoples-uni.org. They provide a wide range of online learning resources beyond those usually found in credit bearing Public Health courses. They are self-paced, and students can enrol themselves at any time and utilise Open Educational Resources free of copyright restrictions.  In the two years that courses have been running, 1174 students from 100 countries have registered and among the 1597 enrollments in 15 courses, 15% gained a certificate of completion. Easily accessible and appealing to a wide geographical and professional audience, OOCs have the potential to play a part in establishing global Public Health capacity building programmes.
Phytoremediation Technologies Application in Industrially Polluted Territories in Environments of East Siberia and South Ural
Authors: Тимофеев  , Timofeev S. , Тимофеева  , Timofeeva Svetlana , Ульрих  , Ulrikh D.
Published: March 2017

A review of modern phytoremediation technologies for rehabilitation of mining industry complexes’ industrially loaded territories has been reported. The wastewater phytoremediation technologies for gold producing mills, enterprises for copper ores extraction and processing have been presented. Practical recommendations on phytoremidiation facilities design have been given. The selection of water plants and algae for planting in bioengineering systems of wastewater treatment, suitable for application in severe climate conditions of East Siberia and South Ural has been performed.
Congenital choledochal cyst
Authors: Heyder Heyder Bin
Published: March 2017

Although congenital choledochal cyst, a localized dilatation of the common bile duct, is an unusual condition in many countries, it should be expected in any infant who presents the triad of jaundice, tumor and pain in the right upper abdomen. Not less than 500 cases have been reported in the medical literature. Recently it is pointed out, that the congenital chledochal cyst is more common in Japan than in Europe or American countries. A personal contact with the Japanese delegation attending the meeting of the Pacific Association of Pediatric Surgeons in Vancouver, May 1971, confirmed it.
Percepções dos portugueses sobre os imigrantes: indispensabilidade, acção colectiva e distância social
Authors: António Raquel , Guerra Rita , Gaertner Samuel L. , Deegan Matthew
Published: March 2017

O presente estudo investigou o impacto de diferentes formas de indispensabilidade grupal na acção colectiva e distância social de um grupo maioritário em relação a diferentes grupos de imigrantes. Mais especificamente, examinámos se a indispensabilidade percebida de diferentes grupos de imigrantes, para a identidade nacional e para o funcionamento da sociedade, a) reduz a distância social e b) aumenta o apoio a acções colectivas que beneficiam os imigrantes, c) através da adopção de diferentes representações grupais (grupo-único, dupla-identidade). 172 Portugueses nativos preencheram um questionário com as medidas de interesse. Os resultados revelaram a mediação esperada. As percepções dos Portugueses acerca da indispensabilidade dos imigrantes estavam associadas a menor distância social e a uma maior participação em acções colectivas, através da adopção de representações identitárias mais inclusivas. Replicando estudos anteriores, estes efeitos positivos devem-se a diferentes tipos de indispensabilidade, para os diferentes grupos de imigrantes, dadas as diferenças nas suas relações históricas com a sociedade de acolhimento.
On Generalizations and Improvements to the Shannon-Fano Code
Authors: Várkonyi D , Hudoba P
Published: March 2017

This paper examines the possibility of generalizing the Shannon-Fano code for cases where the output alphabet has more then 2 (n) symbols. This generalization is well-known for the famous Huffman code. Furthermore, we will be looking at possible improvements to the algorithm, as well as other entropy based lossless data compression techniques, based on the same ideas as the Shannon-Fano code. All algorithms discussed in the paper were implemented by us in C++, and we will be illustrating our hypotheses with test results, made on an average performance PC.
Gamified Solutions in Healthcare - Testing Rehabilitation Games in Finland and Asia
Authors: Luimula Mika , Kattimeri Christina , Katajapuu Niina , Pitkäkangas Paula , Malmivirta Helena , Pyae Aung , Liukkonen Tapani , Smed Jouni
Published: March 2017

This paper presents a comprehensive summary of the Gamified Solutions in Healthcare (GSH) research project, which is a joint research project between Turku University of Applied Sciences and the University of Turku. The goal of the project is to promote exercise, social inclusiveness and enhance quality of life, aiming at developing new services and effective activity solutions for the elderly through gamification. During the research project elderly people were included in the development and testing of games so that they could be used for more than just entertainment purposes. According to all of our tests elderly enjoy playing exergames, and digital games can be an effective way to enhance the quality of life of the elderly. In the case studies it was observed that the players where motivated while playing but motivation should also be maintained throughout the gameplay. The elderly gave overall positive feedback for the idea of using digital activity games for exercising.
Levels of metaphor
Authors: Kövecses Zoltán
Published: March 2017

What is the appropriate conceptual structure involved in conceptual metaphors? Various authors offer a large number of terms to discuss the issue. While domain is the most common term, many others are also used, including frame, image schema, cognitive model, idealized cognitive model, scene, schema, scenario, etc. The problem is compounded by the fact that the terms mean different things to different researchers. The main goal of the paper is to create some clarity in this terminological and theoretical confusion. I propose that conceptual metaphors simultaneously involve conceptual structures, or units, on four levels of schematicity: the level of image schemas, the level of domains, the level of frames, and the level of mental spaces. I call the resulting framework the “multi-level view of conceptual metaphor.” The multi-level view of metaphor can provide us with insights into a number of problems that have been raised and debated in the CMT literature. I show that the study of metaphor within such a framework can legitimately be pursued on the four levels of schematicity and that no level can be singled out as the only appropriate level of analysis.
Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene
Authors: Lopez-Santillan Maria , Iparraguirre Leire , Martin-Guerrero Idoia , Gutierrez-Camino Angela , Garcia-Orad Africa
Published: March 2017

Acute lymphoblastic leukemia (ALL) is a major pediatric cancer in developed countries. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, hypersensitivity reactions are common. In those cases, discontinuation of treatment is usually needed and anti-asparaginase antibody production may also attenuate asparaginase activity, compromising its antileukemic effect. Till now, six pharmacogenetic studies have been performed in order to elucidate possible genetic predisposition for inter-individual differences in asparaginase hypersensitivity. In this review we have summarized the results of those studies which describe the involvement of four different genes, being polymorphisms in the glutamate receptor, ionotropic, AMPA 1 (GRIA1) the most frequently associated with asparaginase hypersensitivity. We also point to new approaches focusing on epigenetics that could be interesting for consideration in the near future.
Courier service quality from the clients’ perspective
Authors: Gulc Aleksandra
Published: March 2017

The aim of the study is a critical analysis of literature concerning the evaluation of courier service quality and verification if client expectations towards courier service quality change in time considering the perspective of future 5–10 years. Research methods include the theoretical analysis of scientific literature, CAWI survey and statistical analysis of obtained data.

The literature overview has shown the lack of clearly defined evaluation constructs of courier service quality together with the criteria and weight, one universal commonly used measuring scale for evaluation of the service quality, diversification of methods and measurement tools for the various groups of stakeholders of courier service. Moreover, it can be concluded that the research concerning the courier service quality has not considered the problem of aging of quality indicators. Research results by the author have proved that the expectations of clients using courier service change in time, some of them are exposed to the aging process (price) while others become more important (for example tele-technologies, modern packaging, and technical facilities). Moreover, the survey results have shown that the customer opinions can be the source of interesting and innovative ideas for the development of courier service in future.

The analysis of domestic and foreign literature allowed presenting the academia with an output concerning the evaluation of quality in the field of courier service. As a result, the theoretical and methodological gaps were revealed to expose potential fields for further research. The research results concerning different methods of service quality evaluation can be useful mainly for managers in courier enterprises. Moreover, the knowledge about changing expectations of clients allows adjusting courier proposals to customer needs to gain a competitive advantage in the global market.
Techniques for designing value propositions applicable to the concept of outcome-economy
Authors: Gierej Sylwia
Published: March 2017

The purpose of this article is to analyse and present some techniques that support the design of a value proposition in the context of the outcome-economy. The proposed techniques are intended to support traditional companies in the design of innovative solutions. Also, the discussed techniques were compared to identify the most effective. The study was conducted based on the information available in the literature on the impact of the Industrial Internet of Things on the economy and creation of a value proposition.
Browser-based Harnessing of Voluntary Computational Power
Authors: Fabisiak Tomasz , Danilecki Arkadiusz
Published: March 2017

Computers connected to internet represent an immense computing power, mostly unused by their owners. One way to utilize this public resource is via world wide web, where users can share their resources using nothing more except their browsers. We survey the techniques employing the idea of browser-based voluntary computing (BBVC), discuss their commonalities, recognize recurring problems and their solutions and finally we describe a prototype implementation aiming at efficient mining of voluntary-contributed computing power.
THE BLACK STONE: Memory of a female serial killer in Bremen
Authors: Holck Per
Published: March 2017

This is the story of the serial killer, Mrs. Gesina Gottfried from Bremen, Germany. She was executed in 1831, being charged and convicted for having murdered at least 16 people, partly from her own family, with arsenic trioxide.
Kajian Perubahan Parameter Sensori dengan Metode Demerit Point Score pada Penurunan Kesegaran Ikan Patin Selama Pengesan
Authors: Ariyani Farida , Hermana Irma , Triwibowo Radestya , Wibowo Singgih
Published: March 2017

Penelitian ini bertujuan untuk mempelajari perubahan parameter sensori pada penurunan kesegaran ikan patin (Pangasius hypopthalmus) selama pengesan menggunakan metode demerit point score (DPS). Percobaan dilakukan dengan mematikan ikan patin secara hypothermia, menyusunnya dalam kotak berinsulasi yang berisi es dengan perbandingan es : ikan = 2:1 (b/b), dan menyimpan kotak tersebut pada suhu ruang. Penggantian es yang mencair dilakukan setiap hari. Penurunan kesegaran ikan diamati secara sensori berdasarkan metode demerit point score (DPS) selama 25 hari dengan interval waktu pengamatan setiap 5 hari terhadap atribut kenampakan, mata, insang, perut, anus dan rongga perut menggunakan skala 0-3 untuk setiap parameter pada masing-masing atribut. Hasil kajian menunjukkan bahwa parameter utama yang menentukan perubahan sensori secara signifikan pada patin segar adalah kenampakan dan kekakuan pada atribut kenampakan umum, kejernihan dan bentuk pada atribut  mata, warna dan bau pada atribut  insang, bau pada atribut anus, dan stains pada atribut  rongga perut. Adapun beberapa parameter yang relevansinya rendah terhadap penilaian panelis pada penurunan kesegaran patin antara lain lendir permukaan pada atribut kenampakan umum, darah pada atribut mata, lendir pada atribut insang, kekakuan dan diskolorasi pada atribut perut, dan kondisi pada atribut anus, sedangkan parameter kulit tidak memiliki relevansi terhadap penilaian panelis pada penurunan kesegaran patin. Berdasarkan penilaian panelis terhadap semua atribut, lama penyimpanan patin segar yang dinyatakan ditolak panelis adalah 25 hari.
Twelve tips for promoting professionalism through reflective small group learning
Authors: Neve Hilary , Morris Rachel
Published: March 2017

This article was migrated. The article was marked as recommended. The importance of placing small group learning at the heart of professionalism curricula is increasingly being recognised within undergraduate medical education. Facilitated small groups provide a valuable setting for students to reflect upon their experiences and to learn about broad aspects of professionalism. By better understanding relevant learning theory and evidence, we can identify approaches for increasing the effectiveness of such groups and overcoming potential barriers to learning. Training facilitators is a vital part of this process. The following tips are based on the literature and the authors' experiences of leading small group learning programmes in two UK medical schools. They provide guidance and ideas for designing an experiential small group learning programmed focused on professionalism and for supporting and training a team to facilitate effective learning in this setting.
A lírica do pelourinho
Authors: Figueiredo Priscila
Published: March 2017

Este artigo procura analisar a mudança operada no último livro de Francisco Alvim, O metro nenhum, em relação às obras anteriores, sobretudo Elefante, nos quais os poemas líricos não tratam diretamente do "sistema de nossos constrangimentos sociais" (Roberto Schwarz), de que se ocupam em geral os poemas mais crítico-realistas do autor. A análise se concentra sobretudo numa composição como "A mão que escreve", em que ambas as tendências estão perfeitamente fundidas. O que favorece essa fusão é também a autoanálise do intelectual ante a pesada herança moral e social legada pela escravidão.
Fecal microbiota transplant by push enteroscopy to treat diarrhea caused by Clostridium difficile
Authors: Ganc Arnaldo José , Ganc Ricardo Leite , Reimão Sílvia Mansur , Frisoli Junior Alberto , Pasternak Jacyr
Published: March 2017

ABSTRACT Clostridium difficile is the major etiological agent of pseudomembranous colitis and is found in up to 20% of adult inpatients. The recommended treatment is antibiotic therapy with metronidazole and/or vancomycin. However, the recurrence rate may reach up to 25% and it increases in each episode. The newest alternative to treat diarrhea due to recurrent Clostridium difficile is fecal microbiota transplantation. The procedure was performed in 12 patients, with a 6-month follow-up on 10 of them. Of the ten cases, bacterial recurrence was diagnosed in only one patient, after a course of antibiotic to treat urinary tract infection, without presenting with diarrhea. The particularity of our study, besides being an unprecedented event in South America, is the way to perform the infusion of fecal microbiota by enteroscopy.
Surface modification of molybdenum disulfide (MoS2) fine powder
Authors: Zhou Xiantao , Wang Yimou , Chen Jian , Liu Anlin , Ma Liang
Published: March 2017

This work reports a novel method to chemically modify the surface of molybdenum disulfide (MoS2) powder that is used as the antigalling filler in the lubricants for thread-tubing in oil pipelines. The modification by way of coupling agents effectively reduces friction and improves the antiwear and antigalling properties. The effects of three coupling agents, including KH-570, polyvinylpyrrolidone and hexadecyl cetyltrimethylammonium bromide, on particle resistance to sedimentation, powder activation index and lipophilicity are compared in detail. KH-570 on the powder improves the lipophilicity and the dispersion stability of MoS2. The modified MoS2 exhibits a much improved activation index, more than twice the original MoS2 powder. The amount of DOP absorbed by modified MoS2 powder decreases significantly. The turbidity is much higher in the modified MoS2 powders, this is in good accordance with the findings from other tests – that is, the lipophilicity has improved. The lipophilicity of the modified MoS2 increases then decreases with the increased concentration of KH-570. Overall, KH-570 outperforms the rest and is further explored for optimisation and coupling mechanism.
Centrifuge modelling of rock bolts with facing plates
Authors: Nakamoto Shion , Iwasa Naoto , Takemura Jiro
Published: March 2017

In this study, a series of centrifuge model tests were carried out to study the mechanical behaviour of the slope reinforced by a soil nailing method using rock bolts with prestressed facing plates. A centrifuge model testing system was developed, in which the preloading process of rock bolts with a facing plate in a model slope can be simulated by hoisting jacks, and pseudo-static seismic force can also be imposed on the slope by a tilting table. Simplified tests of the reinforced slope were performed with various preloading forces. The displacements of the facing plates and the slope surface, and the facing stresses were measured during both the preloading process and the tilting table tests. It was found that the reinforcement of slopes by the rock bolts with facing plates could effectively prevent deformation and failure. The larger the prestress is, the smaller the slope deformation. However, the effect of prestress increment on slope stability became smaller as the prestress increased, especially after large deformations. The deformation of the slope was deeper and wider for the reinforcement with smaller prestress, while for those with larger prestress it becomes shallower in limited local areas.
A emergência do conceito de perversão no século XIX
Authors: Peto Lucas Carvalho , Verissimo Danilo Saretta
Published: March 2017

Neste trabalho, problematiza-se a emergência do conceito de perversão a partir do declínio da primazia jurídica sobre as práticas sexuais, âmbito apropriado, em concomitância às demandas estruturais do contexto moderno, pelo discurso positivo-organicista da medicina. Num primeiro momento, investigam-se as vicissitudes sobre o corpo no discurso eclesiástico medieval. Posteriormente, procedendo-se à análise do contexto político-econômico europeu nos séculos XVII e XVIII, questionam-se os postulados jurídicos sobre o corpo e as práticas sexuais, e suas concomitantes respostas às demandas político-econômicas. Por fim, empreende-se uma discussão sobre as atualizações epistemológicas referentes às práticas sexuais, provenientes da primazia imputada ao discurso médico-positivo no século XIX.
Os Encontros Nacionais da Indústria (ENAIs): a burguesia industrial agindo como força social e coletivamente organizada.
Authors: Cadoná Marco Andre
Published: March 2017

Na bibliografia que analisa a atuação política da burguesia industrial no Brasil a partir da democratização do País (1980), um dos pontos de discordância está relacionado com a capacidade das lideranças políticas dessa fração burguesa no País em aglutinar a complexidade dos interesses industriais em torno de uma agenda política comum.Neste artigo, a mobilização da Federação das Indústrias do Estado do Rio Grande do Sul,visando à participação nos Encontros Nacionais da Indústria promovidos pela Confederação Nacional da Indústria durante o segundo governo Lula (2007 – 2010), é tomada como referência empírica para a análise da capacidade política que as entidades de representação da burguesia industrial no Brasil têm demonstrado para aglutinar o segmento enquanto força social e coletivamente organizada e viabilizar ações conjuntas em torno de objetivos comuns.
A deficiência simbólica na subjetividade pós-moderna: bases para uma sociedade narcísica.
Authors: Silva André Luiz Picolli da , Viana Terezinha De Camargo
Published: March 2017

Na atualidade, o elevado grau de ocorrência de patologias narcísicas, tem feito com que muito pesquisadores nas áreas de psicologia e psicanálise considerem o narcisismo como uma tipologia psíquica característica da sociedade pós-moderna. Objetivando ampliar e aprofundar, a partir de uma perspectiva psicanalítica, a compreensão sobre a relação entre esses dois fenômenos, o narcisismo e a sociedade, o presente trabalho levanta a hipótese de que o surgimento do elevado grau de narcisismo na sociedade pós-moderna tem como um de seus fatores o esvaziamento do poder do conhecimento científico e do conhecimento tradicional que, simbolicamente, podem ser entendidos como figuras paterna e materna na sociedade atual. Partindo da premissa de que uma tipologia psíquica da sociedade se desenvolve de modo idêntico ao desenvolvimento psíquico do indivíduo, discute-se como o poder simbólico do Pai e da Mãe vem se enfraquecendo desde a segunda metade do século XX, a tal ponto que as instituições sociais não conseguem mais se configurar plenamente como objetos identificação e satisfação libidinal.
Análise crítica de “o livro negro da psicanálise: viver e pensar melhor sem Freud”
Authors: Bracks Mayana , Calazans Roberto
Published: March 2017

O presente artigo procura conduzir uma análise e um debate com base nas críticas feitas à psicanálise, as quais se encontram presentes na primeira parte da obra O Livro Negro da Psicanálise - Viver e Pensar melhor sem Freud. Cotejamos essas críticas com a letra do texto freudiano com a finalidade de averiguar se as mesmas são pertinentes. Delimitou-se à primeira seção por ela ter capítulos que compreendem uma dimensão importante para a teoria e para a clínica psicanalítica: a noção de sexualidade, além de melhor apontar quais são os pressupostos clínicos e epistemológicos que sustentam a crítica à psicanálise.
Efficacy of adalimumab for Crohn’s disease in real clinical practice
Authors: Knyazev O V , Kagramanova A V , Ruchkina I N , Fadeeva N A , Lishchinskaya A A , Boldyreva O N , Zhulina E Yu , Shcherbakov P L , Orlova N V , Kirova M V , Parfenov A I
Published: March 2017

Aim. To evaluate the efficacy and safety of adalimumab (ADA) in patients with Crohn’s disease (CD) treated at the Department of Inflammatory Bowel Diseases, Moscow Clinical Research and Practical Center, and to determine the predictors of a therapy response. Subjects and methods. All the patients with CD treated with ADA were followed up for at least 6 months or until the drug was discontinued. Therapeutic effectiveness was evaluated at 4 weeks and 6 months after the initiation of treatment and at the end of a follow-up. Complete intestinal mucosal healing was assessed at 3 and 12 months following treatment initiation. Univariate and multivariate analyses were used to determine the predictors of treatment response. Results. A clinical analysis covered 70 patients (57.1% male); the follow-up period averaged 112 weeks. Perianal fistulas were at baseline established in 22 (31.4%) patients with CD. 12 (17.4%) patients had been previously treated with infliximab (INF), 7 of them discontinued the drug for secondary loss of response and 5 for adverse reactions. 68 (97.1%) patients responded to an induction course of ADA. At 4 weeks, 6 months, and at the end of the follow-up, clinical remission occurred in 66.7, 80.4 and 67.4 % of patients with luminal CD and in 45.4, 36.5, and 36.4% of those with perianal CD, respectively. At 3 and 12 months and at the end of the follow-up, there was complete healing of the intestinal mucosa in 23.5, and 41.2 and 29.5% of cases, respectively. Six (8.8%) patients responding to the induction course needed to be optimized with ADA to 40 mg weekly. The time interval between treatment initiation and dose optimization averaged 30 weeks (range 12-120 months). There were 15 (21,4%) adverse events that were responsible for ADA discontinuation in 3 (4,2%) patients. Conclusion. The findings demonstrate the efficacy and safety of ADA used in clinical practice.
Ultrasound elastography of the liver for assessing the risk of complications of its cirrhosis of different etiologies
Authors: Stukova N Yu , Kucheryavyi Yu A , Mayevskaya E A , Maev I V
Published: March 2017

Aim. To study the results of dynamic liver ultrasound elastography (LUE) in assessing the risk of complications of liver cirrhosis (LC) of different etiologies and to elaborate a monitoring program for estimation of the predictive value of elastography in patients with LC. Subjects and methods. A total of 194 patients with LC of different etiologies, including 56 patients with alcoholic cirrhosis, 48 with LC and an outcome of nonalcoholic fatty liver disease, 53 with LC and an outcome of chronic hepatitis C, 23 with LC and an outcome of chronic hepatitis B, and 14 with an outcome of coinfection with hepatitis B and D viruses, were examined. An analysis was made between the presence of a number of LC complications and the results of LUE, by constructing the receiver operating characteristic (ROC) curves to select LUE threshold values, in which there was a high risk for LC complications (esophageal varices, bleeding esophageal varices, hepatic encephalopathy, and ascites). Results. The investigation could obtain liver elastography threshold values expressed in kilopascals (kPa), which were proposed for use as a prognostic sign of the presence of complications caused by LC and assessed liver elastography threshold values for its mortality prediction. The predictive value of positive LUE results in determining the risk of different complications was 75.7 to 92.5%; that of negative results was 70 to 92.9%. An algorithm for individualized diagnostic and treatment policy was elaborated in relation to the liver elastography results obtained during the primary examination of a patient. Conclusions. The dynamic LUE findings in patients with LC of different etiologies suggest that the proposed LUE threshold values are efficient and may be used in practical healthcare, which will be able to timely correct management tactics for a patient and to monitor his treatment.
Neurological disorders associated with gluten sensitivity
Authors: Degterev D A , Damulin I V , Parfenov A I
Published: March 2017

The review considers the pathogenetic, clinical, and therapeutic aspects of neurological disorders associated with gluten sensitivity. Gluten ataxia and polyneuropathy are most common. The clinical features of neurological disorders in patients with gluten sensitivity and the effects of a gluten-free diet are described.
Magnitud del tamaño del efecto y su importancia en la investigación pediátrica.
Authors: Caycho T
Published: March 2017

En la actualidad se hace cada vez más común el empleo de medidas del tamaño del efecto al momento de informar los resultados de investigaciones en ciencias de la salud en general1 (y pediatría en particular)2,3 debido a que brindan a la comunidad académica una interpretación más completa en comparación a la brindada por el test de significancia de la hipótesis nula (NHST, por sus siglas en inglés).
DCE-MRI Texture Features for Early Prediction of Breast Cancer Therapy Response
Authors: Thibault Guillaume , Tudorica Alina , Afzal Aneela , Chui Stephen Y-C. , Naik Arpana , Troxell Megan L. , Kemmer Kathleen A. , Oh Karen Y. , Roy Nicole , Jafarian Neda , Holtorf Megan L. , Huang Wei , Song Xubo
Published: March 2017

This study investigates the effectiveness of hundreds of texture features extracted from voxel-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parametric maps for early prediction of breast cancer response to neoadjuvant chemotherapy (NAC). In total, 38 patients with breast cancer underwent DCE-MRI before (baseline) and after the first of the 6–8 NAC cycles. Quantitative pharmacokinetic (PK) parameters and semiquantitative metrics were estimated from DCE-MRI time-course data. The residual cancer burden (RCB) index value was computed based on pathological analysis of surgical specimens after NAC completion. In total, 1043 texture features were extracted from each of the 13 parametric maps of quantitative PK or semiquantitative metric, and their capabilities for early prediction of RCB were examined by correlating feature changes between the 2 MRI studies with RCB. There were 1069 pairs of feature–map combinations that showed effectiveness for response prediction with 4 correlation coefficients >0.7. The 3-dimensional gray-level cooccurrence matrix was the most effective feature extraction method for therapy response prediction, and, in general, the statistical features describing texture heterogeneity were the most effective features. Quantitative PK parameters, particularly those estimated with the shutter-speed model, were more likely to generate effective features for prediction response compared with the semiquantitative metrics. The best feature–map pair could predict pathologic complete response with 100% sensitivity and 100% specificity using our cohort. In conclusion, breast tumor heterogeneity in microvasculature as measured by texture features of voxel-based DCE-MRI parametric maps could be a useful biomarker for early prediction of NAC response.
O caráter problemático de Paulo Honório
Authors: Ferreira Raul Azevedo De Andrade
Published: March 2017

O presente artigo revisita uma tradição interpretativa do romance São Bernardo, de Graciliano Ramos, apoiada na categoria de herói problemático, lançada por Georg Lukács em sua Teoria do Romance (1914). Argumenta-se que as leituras produzidas por críticos como Lafetá (1984) e Abdala Júnior (2007) apoiam-se em uma leitura enviesada dos conceitos do filósofo húngaro e que, por conta disso, podem ser reconsideradas. Por fim, o texto retoma a tipologia do herói romanesco lançada por Lukács e propõe uma interpretação do romance do autor alagoano na qual seu protagonista passa a ser entendido como um idealista quixotesco.PALAVRAS-CHAVE: São Bernardo. Graciliano Ramos. Teoria do Romance.
ENTRELAÇOS DA FORMAÇÃO DOCENTE: VIVENCIANDO O COTIDIANO ESCOLAR ATRAVÉS DO PIBID
Authors: Araújo Edinaura Almeida de , Pereira Zildene Francisca , Dantas Nozângela Maria Rolim
Published: March 2017

Resumo: A formação do professor iniciada nos cursos de graduação configura-se como o momento de definição, escolhas, envolvimento e aceitação da profissão. É também um período de reflexão e empoderamento do projeto educacional que congrega ações pedagógicas, metodológicas e culturais definidas e redefinidas em consonância com os contextos políticos, sociais, econômicos e culturais de cada região, cidade e/ou comunidade. O resultado das atividades está estritamente relacionada ao perfil do professor, que na sua ação cotidiana docente imprime as marcas de uma formação, princípios éticos e compromisso social adquiridos e/ou aperfeiçoados ao longo da vida acadêmica e da formação na vida em sociedade. O trabalho intitulado Entrelaços da formação docente: vivenciando o cotidiano escolar através do PIBID configura-se como uma reflexão acerca do Programa Institucional de Bolsas de Iniciação à Docência/PIBID, um projeto que promove a convivência e aprendizagem dos alunos no Centro de Formação de Professores da Universidade Federal de Campinha Grande - PB – CFP/UFCG - com escolas parceiras. Considerando a importância de conhecer o projeto traçou-se como objetivo reconhecer a importância do PIBID na formação do docente, aluno de graduação, refletir sobre a inovação estabelecida na formação a partir da iniciação à docência através das parcerias estabelecidas com escolas de Ensino Fundamental e Médio. No tocante à metodologia adotada, buscou-se a partir da pesquisa bibliográfica uma reflexão do subprojeto de Pedagogia, considerando a discussão da formação docente a partir luz dos teóricos: Alarcão (2003), Libâneo (2004), Guimarães (2005), Freitas (2007), Ferreira (2007), dentre outros.  Palavras-chave: Formação docente. PIBID. Vivências escolares.
REFLEXÕES ACERCA DA FORMAÇÃO DOCENTE NOS CURSOS DE LICENCIATURA: POTENCIALIDADES DO ENTRELAÇAMENTO ENTRE PSICOLOGIA DA EDUCAÇÃO E PRÁTICA DE ENSINO
Authors: Cunha Rafael da Silva da , Ribeiro Cynara Teixeira , Soares Alessandra Miranda Mendes
Published: March 2017

Resumo: O presente trabalho visa analisar as contribuições das disciplinas Psicologia da Educação e Prática de Ensino nos cursos de formação docente, especialmente no âmbito da Licenciatura em Computação e Informática (LCI), como também apresentar uma experiência de entrelaçamento destas duas disciplinas, realizada a partir de um projeto de extensão. A escolha da LCI justifica-se pelo fato de ser recente no Brasil e comprometer-se com a qualificação dos futuros professores para o uso das Tecnologias da Informação e Comunicação (TICs) no processo educativo. A experiência consistiu na aproximação de licenciandos com a realidade de escolas circunvizinhas à Universidade, com foco nas percepções de como as TICs estão articuladas à prática pedagógica para a posterior elaboração de oficinas pertinentes às demandas institucionais. Através desta experiência vislumbramos práticas pedagógicas capazes de contribuir para o saber-fazer e o aprender a ensinar a partir da ação-reflexão-ação.  Palavras Chave: Formação Docente. Interdisciplinaridade. TICs.