bluuebunny/crossref_metadata_2025 huggingface dataset:
Extraction and Chemical identification of certain antifungal compounds from the pigmented fungus Epicoccum nigrum against phytopathogenic fungus Fusarium solani
Authors: Ali Sally A. , Abdelmoaty Hazem S. , Ramadan Hend H. , Salman Yomna B.
Published: January 2023

Epicocum nigrum strain AUMC 15771 was isolated from E.miliileaves, as well as four endophytic fungi were isolated from E.hirtaleaves which were collected from Helwan University garden. On the basis of antifungal activities of the five isolated endophytic fungi against phytopathogenic F.solani.
Epicocum nigrum achieved a strong inhibition percent (94%). Ethyl acetate extracts of the cultural filtrates were active against F. solanicompared to the control and other extracts (Dichlorometane, Chloroform:Methanol (2:1). Both Light microscopy and Scanning electron microscopy showed that higher concentrations of Ethyl acetate extract caused a change in hyphal aggregation and spore′s formation of F.solani. Furthermore, higher concentrations of Ethyl acetate extracts of E.nigrum had a slight phytotoxic effect on Faba been (Vicia Faba.L) germination and root length compared to lower Ethyl acetate extract concentrations. Identification of antifungal agents in Ethyl acetate extract using GC-MS analysis revealed the presence of 2, 2, 3, 3, 4, 4-Hexadeutero Octadecanal, 2, 2-Dideutero Octadecanal, and Isochiapin B as major components that could be have antifungal and antimicrobial substances. These results offer a viable and sustainable alternative to using E.nigrum extracts for controlling phytopathogenic F.solani.
Direct-Mapping Cross-Interfaces Computed Tomography
Authors: Gong Bugao , Ling Chen , Wu Yue
Published: January 2023

This work reports an optimized tomography method, termed Direct-Mapping Cross-Interfaces Computed Tomography (DMCICT), with enhanced calculation efficiency and accuracy for three-dimensional (3D) reconstruction in confined space. Confined-space tomography methods are designed to correct the image distortion on recorded target images caused by light refraction through optical walls, such as optical engine cylinders. However, past confined-space tomography methods have shortcomings in reconstruction accuracy and time efficiency, since they usually involve time-consuming iterations or numerical interpolation during calculating the mapping relationship from 3D measurement domain to 2D imaging planes. There, DMCICT is developed in this work to directly calculating the mapping relationship by performing reverse ray-tracings originated from imaging planes, then decide the intersection volumes with discretized measurement domain. Numerical and experimental validations of DMCICT are respectively performed based on multiple simulated phantoms and a two-branch laminar flame contained inside an optical cylinder. Compared to past confined-space reconstructions, DMCICT can reduce more than 50% of the computational time in majority of tested cases, while the reconstruction accuracy is also significantly enhanced. Moreover, DMCICT demonstrates the robustness under different spatial resolution conditions and presents solid endurance on measurement errors.
Psychoneurological symptoms and inflammatory markers in patients with glioma in China: a network analysis
Authors: Li Huayu , Shi Xiaohan , Li Jing , Zhang Xinrui , Li Feng
Published: January 2023

Purpose Anxiety, depression, sleep disorder, fatigue, and pain develop as common psychoneurological symptoms in patients with glioma, and their occurrence and development are potentially related to inflammatory factors. However, this theory has not been proven within the context of glioma. This study aimed to estimate interconnections among psychoneurological symptoms and inflammatory biomarkers by a network analysis.
Patients and methods We selected 203 patients with stage Ⅰ-Ⅳ glioma from a tertiary A hospital in China using convenient sampling method. Patients completed the self-made questionnaires, Hamilton anxiety scale-14 (HAMA-14), Hamilton Depression Scale-24 (HAMD-24), Pittsburgh Sleep Quality Index (PSQI), Multidimensional Fatigue Inventory-20 (MFI-20), and Numerical Rating Scale (NRS). The plasma inflammatory cytokines were examined. Partial correlation network analysis was performed to illustrate interactions of symptoms and inflammatory biomarkers.
Results Among the 203 included patients, all psychoneurological symptoms, except for depression and pain, exhibited significant connections with each other. Depression, anxiety, fatigue, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) with higher strength centrality indices were identified as the most central node within the symptom-biomarker networks.
Conclusion Depression, anxiety, fatigue, IL-6, and TNF-α play a significant role in the symptom-biomarker network in patients with glioma. Medical staff should strengthen the dynamic evaluation of the involved symptoms and inflammatory cytokines, and take effective measures to alleviate the burden of symptoms and improve the quality of life of patients.
Examination of gametocyte protein 22 localization and oocyst wall formation in Eimeria necatrix using laser confocal microscopy and scanning electron microscopy
Authors: Wang Lele , Liu Dandan , Gao Yang , Hou Zhaofeng , Zhu Yu , Wang Feiyan , Li Wenjing , Zhang Amin , Xu Jinjun , Hu Junjie , Tao Jianping
Published: January 2023

Background
Eimeria parasite infection occurs via ingestion of oocysts. The robust, bilayered oocyst wall is formed from the contents of wall forming bodies (WFBs), WFB1 and WFB2, located exclusively in macrogametocytes. Eimeria necatrix gametocyte proteins 22 and 59 (EnGAM22 and EnGAM59) have been found to localize to WFBs and the oocyst wall. However, the exact localization of these two proteins is not clear. The mechanisms of macrogametogenesis and oocyst wall formation in E. necatrix are also unknown.
Methods
WFBs of E. necatrix were extracted from purified gametocytes using a cut-off filter and observed by negative stain electron microscopy to assess the intactness of the WFBs. The extracts of purified WFBs and gametocytes were analyzed using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting. Then, the localization of EnGAM22 and EnGAM59 proteins was determined using an indirect immunofluorescence assay. Finally, the development of macrogametocytes and the oocyst wall of E. necatrix was analyzed using laser confocal microscopy and scanning electron microscopy.
Results
Purified WFBs had the same shape and size as those observed in macrogametocytes. EnGAM22 protein localized to WFB1, whereas EnGAM59 protein localized to WFB2. Both EnGAM22 and EnGAM59 native proteins were detected in the extracts of WFBs and gametocytes. The outer layer of the oocyst wall was formed by the release of the contents of WFB1 at the surface of the macrogametocyte to form an anti-EnGAM22 positive layer. WFB2 then appeared to give rise to the inner layer, which was anti-EnGAM59 positive.
Conclusions
EnGAM22 and EnGAM59 proteins localized to WFB1 and WFB2 and were involved in the formation of the outer and inner layers of the oocyst wall of E. necatrix, respectively. The processes of macrogametogenesis and oocyst wall formation of E. necatrix are similar to other Eimeria parasites. The anti-EnGAM22 antibody could be used as a tool to track the transport and secretion of proteins in WFB1 during oocyst development.
High efficiency lossless image recompression algorithm with asymmetric numeral systems for real-time mobile application
Authors: Sheng Qinghua , Zhu Haonan , Sheng Haixiang , Huang Xiaofang , Jiang Jie , Lai Changcai
Published: January 2023

JPEG images are widely used by individual users, data centers, cloud storages and network file systems. The huge transmission and storage bandwidth of existing JPEG images is becoming a big challenge due to its low compression efficiency. Some methods such as Google’s Brunsli can further compress these JPEG images adequately and restore them back to JPEG format losslessly when needed, but its decoding speed is not fast enough especially for real-time mobile applications. To further reduce its decoding complexity, we proposed three optimizations based on Brunsli, which include using asymmetric numeral systems coding to replace the existing arithmetic coding, designing the joint encoding of multiple symbols and cache-friendly optimizing the data structures. Experimental results demonstrate that compared with Brunsli, the proposed method achieves average 2 to 2.4 times decoding faster on mobile platform with comparable compression efficiency which is really valuable for power sensitive real-time mobile applications.
WITHDRAWN: FPGA Based Architecture for Quantum Communication System
Authors: BASIL NOORULDEN
Published: January 2023

This paper presents the equipment and programming design that can be utilized in these frameworks which carries out pragmatic quantum key conveyance (QKD) and quantum arbitrary number age (QRNG). Plans This engineering makes the most of the capacities of the framework on a chip (SoC) that executes Programmable door cluster (FPGA) and double center CPU. Relegating time-bound errands For FPGA and CPU the executives, we have made an adaptable framework with ideal asset designation. A business off-the-rack (COTS) assessment board that incorporates the SoC. Likewise with a change For information stream, the general framework design can be utilized as QKD transmitter, QKD collector. what's more, the control and acknowledgment unit QRNG. At last, we utilized double center execution and saw the synchronization QKD carries out equipment streams to execute stream dispatchers where the bit is continually getting new information. One runs at a decent rate from an outside QRNG source and different sudden spikes in demand for a FPGA Communicating a qubit to a QKD collector. The framework was effectively tried during a long exhibit Its strength and security. This confirmation prepares for a safer execution of QKD. Since QKD states are produced by a totally evident stochastic interaction with genuine outright security Not with explicit augmentation components. At last, it permits us to see a singular amount The transmitter incorporates arbitrary numbers and qubit age.
The Effects of Combination Treatment T4 and T3 on Diastolic Functions and Atrial Conduction Time in Women with Low T3: A short term Follow-up Study
Authors: Büber İpek , Eraydın Ayten , Sevgican Cihan İlyas , Tekin Işık , Kılıç İsmail Doğu , Fenkçi Semin Melahat
Published: January 2023

Purpose
To investigate the effects of combination thyroid replacement treatment on left atrial volume (LAV), diastolic functions, and atrial electromechanical delays in women with low triiodothyronine (T3) levels.
Methods
The study consisted of forty-seven female patients with primer hypothyroidism. The patients who had low T3 levels, despite using tetraiodothyronine (T4) treatment for a while with normal thyrotropin (TSH) and T4 levels with levothyroxine (LT4) treatment and started combination therapy were included in the study. Biochemical samples (TSH, free T4, free T3) were taken, and an echocardiographic assessment was performed for patients at first admission and after approximately six months of receiving T3 (12.5 mcg) treatment.
Results
There was a statistically significant reduction at left ventricle (LV) end-systolic diameter (27.69 ± 3.14, 27.13 ± 2.89, 0.035), left atrial (LA) maximum volume (14.73 ± 3.22, 13.94 ± 3.15, 0.009), LA minimum volume(7.84 ± 2.45, 6.84 ± 2.30, < 0.001), LA vertical diameter (44.08 ± 6.92, 34.60 ± 4.31, < 0.001), LA horizontal diameter (45.65 ± 6.88, 33.43 ± 4.51, < 0.001), LAVI (50.73 ± 18.62, 41.0 ± 13.02, < 0.001), total conduction time (103.69 ± 12.70, 79.82 ± 18.40, < 0.001) after T3 replacement (respectively pre-post treatment and p-value).
Conclusion
The results of the current study suggest that adding T3 to LT4 treatment may improve LAVI and atrial conduction times in patients with low T3. However, more research with larger patient groups is needed to better understand the effects of combined hypothyroidism treatment on cardiac functions.
Automatic and manual prediction of epileptic seizures based on ECG
Authors: MBAREK Manef BEN , ASSALI Ines , HAMDI Salah , ABDALLAH Asma BEN , DAVID Olivier , AISSI Mouna , CARRERE Marcel , BEDOUI Mohamed HEDI
Published: January 2023

This study presents a new attempt to quantify and predict changes in the ECG signal in the pre-ictal period. In the proposed approach, threshold techniques were applied to the standard deviation (STD) of two Heart rate variability features (The number of heartbeats per two minutes and approximate entropy) computed to ensure prediction and quantification of the pre-ictal state. We analyzed clinical data taken from two epileptic public databases, Siena Scalp EEG and Post-Ictal Heart Rate Oscillations in Partial Epilepsy and a local database. By testing the proposed approach on the Siena scalp EEG database, we achieved a sensitivity of 100%, specificity of 95%, and an accuracy of 96.4% whereas using acquisitions from the post-Ictal database, we achieved a sensitivity of 100%, specificity of 91% and an accuracy of 94% and using the local database we achieved a sensitivity of 100%, a specificity of 97% and an accuracy of 97.5%. Furthermore, the proposed approach predicted 58.7%, 57.2, and 40% of the seizures before the onset by more than 10 min for the data taken from post-ictal, local and Siena database, respectively. Using the automatic threshold technique, we were able to achieve a sensitivity, specificity, and accuracy of 85%, 81%, 82% using our local database respectively, whereas using acquisitions take from the Siena Scalp EEG database, we achieved a sensitivity of 75%, specificity of 85% and an accuracy of 82%. Besides, using the post-ictal database, we achieved a sensitivity of 90%, a specificity of 83% and an accuracy of 85%.
Identification of hub genes in liver hepatocellular carcinoma based on weighted gene co-expression network analysis
Authors: Sun Jiawei , Zhang Zizhen , Cai Jiaru , Li Xiaoping , Xu Xiaoling
Published: January 2023

Methods: Our study mainly used The Cancer Genome Atlas (TCGA) LIHC database and the gene expression profiles of GSE54236 from the Gene Expression Omnibus (GEO) to explore the differential co-expression genes between LIHC and normal tissues. The differential co-expression genes were extracted by Weighted Gene Co-expression Network Analysis (WGCNA) and differential gene expression analysis methods. The Genetic Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were carried out to annotate the function of differential genes. Then the hub genes were validated using protein-protein interaction (PPI) network. And the expression level and prognostic analysis were performed. The probable associations between the expression of hub genes and both tumor purity and infiltration of immune cells was explored by TIMER.
Results: A total of 68 differential co-expression genes were extracted. These genes were mainly enriched in complement activation (biological process), collagen trimer (cellular component), carbohydrate binding and receptor ligand activity (molecular function) and cytokine−cytokine receptor interaction. Then we demonstrated that the 10 hub genes (CFP, CLEC1B, CLEC4G, CLEC4M, FCN2, FCN3, PAMR1 and TIMD4) were weakly expressed in LIHC tissues, and worse overall survival (OS) and disease-free survival (DFS) in LIHC patients were associated with the lower expression of CFP, CLEC1B, FCN3 and TIMD4. Ten hub genes had positive association with tumor purity.
Conclusion: CFP, CLEC1B, FCN3 and TIMD4 could serve as novel potential molecular targets for prognosis prediction in LIHC.
Dimensionality Reduced Training by Pruning and Freezing Parts of a Deep Neural Network, a Survey
Authors: Wimmer Paul , Mehnert Jens , Condurache Alexandru Paul
Published: January 2023

State-of-the-art deep learning models have a parameter count that reaches into the billions. Training, storing and transferring such models is energy and time consuming, thus costly. A big part of these costs is caused by training the network. Model compression lowers storage and transfer costs, and can further make training more efficient by decreasing the number of computations in the forward and/or backward pass. Thus, compressing networks also at training time while maintaining a high performance is an important research topic. This work is a survey on methods which reduce the number of trained weights in deep learning models throughout the training. Most of the introduced methods set network parameters to zero which is called pruning. The presented pruning approaches are categorized into pruning at initialization, lottery tickets and dynamic sparse training. Moreover, we discuss methods that freeze parts of a network at its random initialization. By freezing weights, the number of trainable parameters is shrunken which reduces gradient computations and the dimensionality of the model's optimization space. In this survey we first propose dimensionality reduced training as an underlying mathematical model that covers pruning and freezing during training. Afterwards, we present and discuss different dimensionality reduced training methods -- with a strong focus on unstructured pruning and freezing methods.
The Relationship Between Work Engagement and Meaninful Work to Well-Being and Aspiration Index in the Health Field: The Case of Psycisians
Authors: PAPADOPOULOU ANNA
Published: January 2023

Background: During the pandemic period, medical personnel became the focus of society's attention. The pandemic appeared to have significantly affected the professional performance of doctors and led to an increase in medical errors. And while research interest so far has focused on burnout and occupational stress in physicians, the study of more positive concepts such as work engagement, meaning at work, and personal well-being may have equally important benefits for the health field for the design of targeted interventions in order to strengthen the human resources of health structures.
Aim: The purpose of this study is to investigate the work engagement of physicians and the finding of meaning in their work in relation to their personal well-being and future life-goals.
Method: For the purpose of the study, a point-in-time study was conducted using questionnaires, in which a total of 116 men and women participated.
Results: The findings indicate that physicians' work engagement indeed contributes to their well-being and confirm that experiencing meaning at work enhances personal well-being.
Conclusion: Taking measures as well as implementing policies that emphasize work engagement and finding meaning in work can improve physician perfor-mance and help reduce medical errors.
MSX1-expression during the different phases in healthy human endometrium
Authors: Eppich Simon , Kuhn Christina , Schmoeckel Elisa , Mayr Doris , Mahner Sven , jeschke udo , Gallwas Julia , Heidegger Helene Hildegard
Published: January 2023

Purpose:
The human endometrium consists of different layers (basalis and functionalis) and undergoes different phases throughout the menstrual cycle. In a former paper our research group was able to describe MSX1 as a positive prognosticator in endometrial carcinomas. The aim of this study was to examine the MSX1 expression in healthy endometrial tissue throughout the different phases to gain more insight on the mechanics of MSX-regulation in the female reproductive system.
Materials and Methods:
In this retrospective study we investigated a total of 19 normal endometrial tissues (7 during proliferative phase and each 6 during early and late secretory phase). We used immunohistochemical staining and an immunoreactive score (IRS) to evaluate MSX1 expression. We also investigated correlations with other proteins, that have already been examined in our research group using the same patient collective.
Results:
MSX1 is highly expressed during the proliferative phase and downregulated at early and late secretory phase (p=0.018). Also, a positive correlation between MSX1 and the progesterone-receptor A (PR-A) (correlation coefficient (cc)=0.0671; p=0.024), the progesterone receptor B (PR-B) (cc=0.0691; p=0.018) was found. A trend towards negative correlation was recognized between MSX1 and Inhibin Beta-C-expression in glandular cells (cc=-0.583; p-value=0.060).
Conclusion:
MSX1 is known as a member of the muscle segment homeobox gene family. MSX1 is a p53-interacting protein and overexpression of homeobox MSX1 induced apoptosis of cancer cells. Here we show that MSX1 is highly expressed especially in the proliferative phase of glandular epithelial tissue of the normal endometrium. Because MSX1 is known to be downregulated by progesterone, the found correlation of MSX1 and both PR-A and -B may represent a direct regulation of the MSX1 gene by a PR-response element.
A Survey on Physical Adversarial Attack in Computer Vision
Authors: Wang Donghua , Yao Wen , Jiang Tingsong , Tang Guijian , Chen Xiaoqian
Published: January 2023

In the past decade, deep learning has dramatically changed the traditional hand-craft feature manner with strong feature learning capability, promoting the tremendous improvement of conventional tasks. However, deep neural networks (DNNs) have been demonstrated to be vulnerable to adversarial examples crafted by small noise, which is imperceptible to human observers but can make DNNs misbehave. Existing adversarial attacks can be divided into digital and physical adversarial attacks. The former is designed to pursue strong attack performance in lab environments while hardly remaining effective when applied to the physical world. In contrast, the latter focus on developing physical deployable attacks, which are more robust in complex physical environmental conditions (e.g., brightness, occlusion, etc.). Recently, with the increasing deployment of the DNN-based system in the real world, enhancing the robustness of these systems is an emergency, while exploring physical adversarial attacks exhaustly is the precondition. To this end, this paper reviews the development of physical adversarial attacks against DNN-based computer vision tasks (i.e., image recognition and object detection tasks), which can provide beneficial information for developing stronger physical adversarial attacks. For completeness, we also briefly introduce the works that do not involve physical attacks but are closely related to them. Specifically, we first proposed a taxonomy to summarize the current physical adversarial attacks. Then we briefly discuss the existing physical attacks and focus on the technique for improving the robustness of physical attacks under complex physical environmental conditions. Finally, we discuss the issues of the current physical adversarial attacks to be solved and give promising directions.
The Effect of Exchange Rate Fluctuation on the Performance of the Manufacturing Sector in Nigeria (1990 -2020)
Authors: Omolola Oyedepo Elizabeth , Mutiu Rasaki Gbade , Onasokhare Addo Gabriel
Published: January 2023

The authors have requested that this preprint be removed from Research Square.
WITHDRAWN: Quantum Communication of Physics Informed Architecture
Authors: BASIL NOORULDEN
Published: January 2023

Quantum communication is a promising development that will play an important role in organizing future associations. To be honest, quantum materials science and legacy exchange networks face great challenges in developing new models, behavioral processes, and logical implementations of the quantum communication community (QCN). However, these companies must advance the current dissatisfaction and there are no youth between the two organizations and the re -establishment of the QCN show of the two organizations and the two organizations. For example, in the old fashion style of the old fashion style, the work of the former cemetery of a specific cemetery. For example, as there are many conversion contracts with quantum notifications, the rules do not agree with the rules, so it does not work, because they are waiting for the endless life. In this article I reported QCN. Because QCN and QCN are divided, QCNS wants to tell you about QCN sharing. This is since both are Retina, because other parts of quantum appear. Then, the need for the proposed approach is evaluated, and the important tasks in the useful QCN composition will be analyzed in different areas of open evaluation. Similarly, we know a new science of materials that can participate in the modern QCN movement in their shows in their show. Finally, we will control various emergency disorders and the disclosure of QCNs to use important research methods to achieve major reasonable results. Finally, this work tries to overcome all the boundaries between conventional communication and quantum material science networks in the QCN space and advances into the future communication community at least 6G and quantum internet.
WITHDRAWN: Sources of Thin Single Photon for Quantum Communications
Authors: BASIL NOORULDEN
Published: January 2023

Until this point in time, quantum correspondence broadly depends on constricted lasers for secret key age. In future quantum networks key restrictions coming about because of their probabilistic photon circulation should be overwhelmed by utilizing deterministic quantum light sources. Conned excitons in monolayers of progress metal dichalcogenides (TMDCs) comprise an original sort of producer for quantum light age. These molecularly dainty strong state sources show engaging possibilities for enormous scope and minimal expense gadget incorporation, satisfying the needs of quantum data advancements. Here, we pioneer the pragmatic appropriateness of TMDC gadgets in quantum correspondence. We utilize a WSe2 monolayer single-photon source to copy the BB84 convention in a quantum key dissemination (QKD) arrangement and accomplish crude key paces of up to 66:95 kHz and antibunching values down to 0:034 - an exhibition serious with QKD tests utilizing semiconductor quantum spots or variety focuses on jewel. Our work opens the course towards more extensive uses of quantum data advances utilizing TMDC single-photon sources.
WITHDRAWN: Ultrafast Quantum Communication with Time Bin Qubits Applied for Biomedical Engineering
Authors: BASIL NOORULDEN
Published: January 2023

One of the most uplifting cases is the phase of quick photonic capacity for quantum matching on fiber associations and free space channels. Specifically, the photon timing pay conditions are impervious to normal rot, support fast correspondences, and can be utilized in cutting edge plans. In any case, it is hard to recognize the conditions of photon time cuts, particularly for photons in a superposition of various time cuts. Here, we tentatively show the span of picosecond light-time groups, known as ultrafast time groups, for applications in quantum perception. We advance the utilization of world states in productive quantum key delivery contracts, for example, the BB84 contract, with the capacity to quantify time 3D shape superpositions with mind boggling accuracy.
Incidence, risk factors, and prognosis of hypokalemia in patients with normokalemia at hospital admission.
Authors: Viswanathan Stalin , Bhargav Jakka
Published: January 2023

Background
Hypokalemia (K+<3.5 mmol/L) is a common electrolyte abnormality observed in 20% of hospitalized patients. Previous studies have often dealt with the symptoms of hypokalemia, its prevalence, and risk factors in hospitalized patients. Very few studies have dealt with hospital-induced hypokalemia. The aim of this study was to find the incidence, predisposing risk factors, and prognosis of patients developing hypokalemia in patients with normokalemia at admission.
Materials and methods
A prospective observational study was performed over a period of two months. Patients with at least two potassium values after admission and normal K values at admission were considered for inclusion. Clinical features, diagnoses, laboratory reports, and treatment details, including antibiotics, were noted. Incidence of hypokalemia was determined. Patients with and without hypokalemia were compared.
Results
A total of 653 patients were studied; 138 (21.1%) developed hypokalemia. Diabetes, ischemic heart disease, heart failure, chronic kidney disease, hypertension, chronic liver disease, and COPD were the most associated comorbidities. Urea, creatinine, transaminases, and neutrophilia at admission differed significantly between those with and without hypokalemia groups. Most patients developed mild hypokalemia (78.2%); moderate and severe hypokalemia developed in 19.5% and 2% of patients, respectively. Hypokalemia developed mostly on the second(22.4%) and third (24.6%) day of hospitalization. Antibiotics were used in 60% of patients, with 23% and 24.5% receiving one and two antibiotics, respectively. Only linezolid and metronidazole use were significant with regard to the patient’s second potassium value. The potassium values returned to normal within 2.5±1.9 days. Three patients subsequently developed hyperkalemia.
Conclusion
Patients admitted under General Medicine mostly developed mild hypokalemia, even if they had multiple risk factors for developing hypokalemia. Inpatient hypokalemia had an incidence of 21%. An overwhelming majority (~88%) had at least one risk factor. Hypokalemia was not attributed to causing mortality in any patient.
SIBLING RIVALRIES
Authors: Qodir Zuly
Published: January 2023

The issues of religious proselytization as well as the construction of house of worship are of main contentious topics inciting tensions between religious adherents, particularly between the minority Christians and the majority Muslims in contemporary Indonesia. This article discusses these two inter-religious problems and poses a question to extent that the competition between Muslim and Christians, both in their missionary activities and the building of new house of worship, inflicting inter-religious relation in contemporary Indonesia. Taken some cases as points of discussion, this article further offers that inclusive dialogue and social justice are solutions to minimize—even to prevent—the worsening tension between Muslim and Christians.
FRAMING ANTI-AMERICAN SENTIMENT AND ITS IMPACTS ON TWO MUSLIM COUNTRIES
Authors: Jati Wasisto Raharjo
Published: January 2023

The term “anti-American” sounds debatable in analyzing the relationship between Islamic world and United States. This term arguably stems from Huntington’s thesis on clash of civilization, which argued that the culture is the main belligerent instead of countries in the conflict. Two main cultures: the contrast between the West and Islam often eventually shapes the rivalry relationship between these two civilizations. Investigating the persistence rivalry between the two through critical literature review method, this article tries to answer the question of why Muslims are still hostile to American culture. It further argues that that media, which are mostly from Middle Eastern countries, have essential in shaping the fluctuated trend of anti-American sentiment among Muslims. This heavily depends on the impact of US foreign policy on Arab that might precipitates anti-American sentiments.
Perkembangan Gaya Hidup Remaja Terhadap Perilaku Imitasi di Kalangan Komunitas Japan Club East Borneo Kota Samarinda
Authors: Huda Arif Nur , Ummah Andrian Khoirul , Salmah Nur , Rismawati Rismawati , Raharja Andri Tria
Published: January 2023

The emergence of Japanese anime in Indonesia is a unique phenomenon considering that there have been many changes in behavior and a special attraction for the youth of this nation. The existence of a community of anime lovers has always been a topic of conversation among other teenagers. The reason is the polemic and the issue that its existence influences imitation behavior for other teenagers. This study aims to find out how the development of adolescent lifestyles towards imitation behavior among the Japan club east Borneo community in Samarinda. This research is a qualitative descriptive research study and the data were obtained through observations of club associations and interviews with several informants. The results of this study indicate that the development of the lifestyle of weaboo adolescents is indeed very developed, a lot of imitative behavior such as cosplay (costum and play) from here is a form of the word imitation. Behavior in this club has another purpose besides the word like or love for anime or Japanese culture. But this also has a positive side, the difference is that they were all able to be united in big events like animfest.
“Quite an Innocuous Thing”: The Select Committee on the Greater Use of Manx Gaelic and language revitalisation in the Isle of Man
Authors: Wilson Gary , Mackie Catriona
Published: January 2023

Over the past several decades, Manx Gaelic, the indigenous language of the Isle of Man, a small island in the British Isles, has undergone a profound process of revitalisation and reintegration into the life of the community. At the forefront of this revitalisation process has been a dedicated group of language activists who saved the language following the death of the last native speakers. More recently, however, the Isle of Man government has supported the revitalisation of Manx, mainly through education planning and support for cultural programming. This article examines the Select Committee on the Greater Use of Manx Gaelic, a committee of the island’s parliament, Tynwald, the internal and external contexts that shaped its deliberations and recommendations and the role it played in signalling a change in the attitude of the government towards Manx in the mid-1980s. The Select Committee highlights the important connection between the political (governance) and social (identity) dimensions of islandness in the revitalisation of an Indigenous language in a small island context.
Jersey Parishes, Iconography and Island Senses of Place
Authors: Hargreaves Peter
Published: January 2023

The Channel Islands are an unusual archipelago. While they are dependencies of the British Crown, they are not part of the United Kingdom and the main islands – Jersey and Guernsey – enjoy a considerable amount of autonomy, as do Guernsey’s subsidiary territories, Sark and Alderney. Jersey’s internal organisation, through a patchwork of administrative territories known as parishes, is unusual for its longevity and does not accord with modern expectations of hierarchical space. It has been argued that for territories to be perceived as places, they need to be maintained and signalled. Iconography is one such form of signalling. Parish iconography in Jersey is addressed predominantly to insiders, encouraging involvement in parish and community. Travelling through the island, iconography, and particularly its manifestation in signage, informs residents as to which parish they are at any time. The varying adoption of iconography reflects parish individualism but has been diffused: once adopted in one parish, it tends to be adopted in others. There are also locations that can – particularly in the context of Jersey - be described as not-quite places, locales whose identities are (at best) emergent. These lack their own iconography and fit poorly into Jersey’s geography of parishes. The efforts put into parish iconography exemplify Jersey islanders’ efforts to establish and maintain identity by cultural assertion and resistance to homogenisation/modernisation. Not just a record of the past, but maintained and renewed, if anything, parish iconography has increased, as Jersey’s parish system has been perceived as threatened.
Delito de femicidio en Chile: aspectos político-criminales de la nueva regulación de la atenuante de arrebato y obcecación
Authors: Guerra Espinosa Rodrigo , Sierra Campos Catalina de los Ángeles
Published: January 2023

Este artículo propone un análisis crítico de la atenuante de responsabilidad de arrebato y obcecación en el marco de la reforma a la regulación del delito de femicidio en Chile. Para ello presentaremos la discusión legislativa, dogmática y jurisprudencial en torno a esta atenuante con relación a un caso real conocido por el Tribunal Oral en lo Penal de Ovalle. Este caso permitirá comprender cómo ha evolucionado la legislación penal en torno a las graves consecuencias derivadas de la violencia intrafamiliar. Conforme a ello, presentaremos una mirada crítica del artículo 390 quinquies del Código Penal chileno que refiere a la atenuante de arrebato y obcecación y, asimismo, algunas de las problemáticas que ha suscitado esta disposición.
El conflicto de interés de los grupos empresariales frente a las normas de conflicto internacional y local desde el derecho internacional privado: estudio de caso Colombia
Authors: Arango Benítez César Andrés
Published: January 2023

Las normas del conflicto internacional representan uno de los campos de mayor interés para las firmas empresariales internacionales. En este escenario, se considerará el papel que cumple el Derecho Internacional Privado (DIPr), y lo que desde ello les compete a las empresas en cuanto a la materia y sobre el estado de la cuestión actual a escala internacional y local. Por tanto, la pregunta central en torno a la cual discurre el presente artículo consiste en analizar ¿Qué impactos jurídicos generan las normas de conflicto internacional en el interés de las partes en las firmas empresariales desde la perspectiva del Derecho Internacional Privado? partiendo de la línea de base de que en el Derecho Internacional Privado las normas de conflicto en las empresas u organizaciones generan dificultades en los grupos de interés que administran dichas normas afectando a los grupos de intereses de las empresas de hecho o de derecho, tomando como estudio el caso colombiano.
La acción de tutela: ¿mecanismo protector de derechos fundamentales y propiciador de reformas constitucionales?. El caso hito de las curules de paz de las víctimas del conflicto armado
Authors: Yáñez Núñez Diego Armando , Rincón Pedraza Henry , Delgado Medina María Gabriela , Niño Ochoa Luis Enrique
Published: January 2023

La acción constitucional de tutela fue concebida por el constituyente como un instrumento que protege y ampara los derechos constitucionales fundamentales, no como un mecanismo reformatorio de la Constitución o impulsor de los mismos, naturaleza por la cual es difícil canalizarla en el contexto de cambio constitucional. Sin embargo, en la presente investigación se aborda el alcance de la acción de tutela en esta materia, dado que a partir de un caso hito se advierte como empieza a intervenir en escenarios exógenos a su naturaleza, como en los cambios plasmados en la Carta Superior, verbigracia, el caso de las curules de paz de las víctimas del conflicto armado, donde una acción de tutela propició la materialización de una reforma a la Constitución Política de Colombia. Todo lo anterior, de conformidad a la trascendencia que está teniendo en el Estado Social de Derecho el juez constitucional y su actuación frente a las otras funciones del Estado. Bajo estos parámetros la investigación plantea como objetivo general, analizar el papel de la acción de tutela respecto de los mecanismos de reforma constitucional en general y, en particular, como impulsora del trámite legislativo de actos legislativos en Colombia.
Análisis del abuso sexual en contra de los niños y niñas en el sur del Casanare en los años 2015 a 2020
Authors: Peláez Parra Milton Herllem
Published: January 2023

Verificadas algunas estadísticas de entidades estatales que dan cuenta del comportamiento de la sociedad Casanareña frente a delitos de tipo sexual donde están involucrados niños y niñas como víctimas, se observa con gran preocupación que este flagelo ha venido en alarmante alza, por lo que al realizar un estudio sobre las estrategias que han utilizado y ejecutado los distintos gobiernos de turno para la prevención de estos delitos, se encuentra que en varias oportunidades la pena de prisión y multa que castiga estos hechos punibles fue aumentada, así mismo, el legislador promulgó algunas normas adicionales con el fin de castigar fuertemente a los victimarios que resulten condenados. Por otro lado encontramos que históricamente se han realizado esfuerzos por imponer castigos extremos como la emasculación química o prisión perpetua los cuales no han prosperado, no obstante, al realizar una comparación entre las normas que agravaron las penas con las estadísticas mencionadas en precedencia, vemos que como pasa en la mayoría de delitos que afectan a esta sociedad, la solución del problema no se encuentra en la norma penal; y consideramos que frente a este delito las alarmas están prendidas, por lo que se propone iniciar un cambio a la cultura casanareña con la intervención directa del Estado quien debe propiciar capacitaciones y planes de manejo del problema desde el mismo foco de toda sociedad que es sin duda la familia.
desafios da enfermagem no cuidado de feridas na atenção primária à saúde
Authors: Assis Bárbara Francisco de , Vieira Carolina de Lourdes Julião , Silva Catia Maria Santos Diogo da , Alves Manoela , Souza Alessandra da Silva , Gonçalves Sebastião Jorge da Cunha
Published: January 2023

O cuidado prestado aos pacientes que necessitam a realização de curativos em feridas é uma pratica corriqueira na Atenção Primaria, portanto o objetivo deste estudo é analisar como o tratamento de feridas é realizado nas Unidades Básicas de Saúde, sabendo das limitações aos profissionas. Trata-se de uma revisão integrativa de abordagem qualitativa e caráter descritivo, a partir de artigos científicos selecionados para a amostra deste estudo a partir das bases de dados BDENF, LILACS, SCIELO BBO no idioma português, no período de setembro a novembro de 2021. Os descritores utilizados foram “Enfermagem”, “Feridas”, “Tratamento”, “Atenção Primaria”. A busca inicial pelos descritores utilizando-se o operador booleano AND permitiu a obtenção de um total de 45 artigos que, após a leitura dos títulos, dos resumos e, em seguida uma análise obedecendo aos critérios de inclusão, permitiu a seleção de 07 estudos que apresentavam relação com a temática questão. Tais estudos foram publicados entre os anos de 2016 a 2021. Para direcionar esta revisão, elegeu-se a seguinte questão norteadora: o Sistema Único de Saúde está preparado para realização do tratamento de feridas minimizando o sofrimento dos pacientes? Diante disto, esbarramos no binômio necessidade x possibilidade inserido na realidade do Sistema básico de saúde, demonstrando a importância de como uma gestão eficaz é capaz de reduzir os impactos da desigualdade do acesso presente nas limitações das possibilidades do poder público.

Palavras-Chave: Enfermagem; Feridas; Tratamento; Atenção Primaria.
Historical Perspectives and Current Advancements in the Bacteriology and Medical Therapy of Struvite Urinary Stone Disease
Authors: F. Schwartz Bradley
Published: January 2023

Struvite calculi have afflicted man for thousands of years. Despite recent advances in surgical technology to treat these disabling stones, high recurrence rates and inability to remove all stone fragments remain significant problems. Previous non-surgical alternatives have been disappointing because of low success rates, increased side effects or poor tolerability. New research in this area continues to provide insight into origins of lithogenesis and non-invasive therapy for calculi caused by infection.
Circular RNAs: Emerging Modulators in the Pathophysiology of
Polycystic Ovary Syndrome and their Clinical Implications
Authors: Mazloomi Sahar , Mousavi Vahide , Aghadavod Esmat , Mafi Alireza
Published: January 2023

Polycystic ovary syndrome (PCOS) is a prevalent endocrine/metabolic disorder
in women of reproductive age. PCOS is characterized by hyperandrogenism,
polycystic ovary morphology, and ovulatory dysfunction/anovulation. It involves multiple
effects in patients, including granulosa/theca cell hyperplasia, menstrual disturbances,
infertility, acne, obesity, insulin resistance, and cardiovascular disorders.

:

Biochemical analyses and the results of RNA sequencing studies in recent years have
shown a type of non-coding RNAs as a splicing product known as circular RNAs (circRNAs).
Several biological functions have been identified in relation to circRNAs, including
a role in miRNA sponge, protein sequestration, increased parental gene expression,
and translation leading to polypeptides. These circular molecules are more
plentiful and specialized than other types of RNAs. For this reason, they are referred to
as potential biomarkers in different diseases. Evidence suggests that circRNAs may
have regulatory potentials through different signaling pathways, such as the miRNA
network.

:

Probably most experts in the field of obstetricians are not aware of circRNAs as a
useful biomarker. Therefore, this review focused on the researches that have been
done on the involvement of circRNAs in PCOS and summarized recent supportive
evidence, and evaluated the circRNA association and mechanisms involved in PCOS.
Biomaterial Based Stem Cells Therapy for Cancer
Authors: Pandey Akanksha , Malviya Rishabha , Sharma Pramod Kumar , Rahate Kalpana
Published: January 2023

Biomaterials are developed to aid a variety of regenerative medicine strategies, such as providing
a framework for cell adhesion and proliferation or serving as carriers of bioactive factors, while stem
cells are increasingly implanted in biomaterial scaffolds to improve therapeutic efficacy. Advanced biomaterials
like metals, synthetic polymers, and ceramics are used in bone regeneration technology. The
ultimate goal of biomaterial-directed SC (stem cells) culture is to replicate the physical and biochemical
characteristics of the physiological SC niche. The primary structural component of tumour ECM (extracellular
matrix) is collagen. Cancer initiation, EMT (epithelial-mesenchymal transition), drug resistance,
and CSC (cancer stem cells) self-renewal have all been linked to collagen subtypes. The enhancement of
liver CSCs has already been investigated using collagen I-based platforms. Alginate and chitosan are two
naturally occurring polymers with biological macromolecules that are similar. Biomaterial-based therapies,
on the whole, offer incredible versatility and tailorability in the fight against the disease. They could
also be used as tissue-engineered scaffolds for immune cell replenishment, potentially making them a key
weapon in the next generation of therapeutic approaches.
Investigation of Bioactivity of Estragole Isolated from Basil Plant on Brain
Cancer Cell Lines Using Nuclear Method
Authors: Avcibasi Ugur , Dewa Mouhaman Toukour , Karatay Kadriye Busra , Kilcar Ayfer Yurt , Muftuler Fazilet Zumrut Biber
Published: January 2023

Background:

In recent years, there has been a significant increase in studies investigating
the potential use of plant-origin products in the treatment and diagnosis of different types of
cancer.

Methods:

In this study, Estragole (EST) was isolated from basil leaves via ethanolic extraction
using an 80% ethanol concentration. The isolation process was performed using the High Performance
Liquid Chromatography (HPLC) method. The EST isolated from the basil plant was radiolabeled
with 131I using the iodogen method. Quality control studies of the radiolabeled EST (131IEST)
were carried out by using Thin Layer Radio Chromatography (TLRC). Next, in vitro cell,
culture studies were done to investigate the bio-affinity of plant-originated EST labeled with 131I
on human medulloblastoma (DAOY) and human glioblastoma-astrocytoma (U-87 MG) cell lines.
Finally, the cytotoxicity of EST was determined, and cell uptake of 131I-EST was investigated on
cancer cell lines by incorporation studies.

Results:

As a result of these studies, it has been shown that 131I-EST has a significant uptake on
the brain cells.

Conclusion:

This result is very satisfying, and it has encouraged us to do in vivo studies for the
molecule in the future.